PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
1482699-1	1992	In a previous study, ethanol was shown to enhance the stimulatory effect of phorbol 12-myristate 13-acetate (PMA), a prominent activator of protein kinase C (PKC), on phospholipase-D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn) in NIH 3T3 fibroblasts (Kiss et al.	Tetradecanoylphorbol Acetate	76-107	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	167-182
1472000-7	1992	Similarly to sphingosine, the protein phosphatase inhibitor okadaic acid also had either potentiating or inhibitory effects on PMA-stimulated PLD activity, depending on the length of incubation time and the concentration of PMA.	Tetradecanoylphorbol Acetate	127-130	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	142-145
1472000-7	1992	Similarly to sphingosine, the protein phosphatase inhibitor okadaic acid also had either potentiating or inhibitory effects on PMA-stimulated PLD activity, depending on the length of incubation time and the concentration of PMA.	Tetradecanoylphorbol Acetate	224-227	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	142-145
1472000-8	1992	Consistent with the presence of an inhibitory component in the overall action of PKC, the PKC inhibitor staurosporine and down-regulation of PKC activity by prolonged (24 h) treatment with PMA similarly enhanced PLD activity.	Tetradecanoylphorbol Acetate	189-192	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	212-215
1482699-1	1992	In a previous study, ethanol was shown to enhance the stimulatory effect of phorbol 12-myristate 13-acetate (PMA), a prominent activator of protein kinase C (PKC), on phospholipase-D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn) in NIH 3T3 fibroblasts (Kiss et al.	Tetradecanoylphorbol Acetate	76-107	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	184-187
1482699-1	1992	In a previous study, ethanol was shown to enhance the stimulatory effect of phorbol 12-myristate 13-acetate (PMA), a prominent activator of protein kinase C (PKC), on phospholipase-D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn) in NIH 3T3 fibroblasts (Kiss et al.	Tetradecanoylphorbol Acetate	109-112	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	167-182
1482699-1	1992	In a previous study, ethanol was shown to enhance the stimulatory effect of phorbol 12-myristate 13-acetate (PMA), a prominent activator of protein kinase C (PKC), on phospholipase-D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn) in NIH 3T3 fibroblasts (Kiss et al.	Tetradecanoylphorbol Acetate	109-112	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	184-187
1332971-1	1992	Transcription of interleukin-6 (IL-6) gene in human HepG2 and HeLa cells was induced by treatment with interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), phorbol 12-myristate 13-acetate, or dibutyryl cyclic AMP.	Tetradecanoylphorbol Acetate	166-197	interleukin 6	Homo sapiens	17-30
1332971-1	1992	Transcription of interleukin-6 (IL-6) gene in human HepG2 and HeLa cells was induced by treatment with interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), phorbol 12-myristate 13-acetate, or dibutyryl cyclic AMP.	Tetradecanoylphorbol Acetate	166-197	interleukin 6	Homo sapiens	32-36
1280205-3	1992	The addition of 10(-7) M 4 beta-phorbol 12-myristate 13-acetate (PMA) to HEC-50 and HEC-1B cells resulted in changes in cell morphology, growth inhibition, activation of PKC, and an increase in expression of IGFBP-1.	Tetradecanoylphorbol Acetate	25-63	NDC80 kinetochore complex component	Homo sapiens	84-89
1447224-3	1992	However, 20 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) and 10(-6) M angiotensin II (AII) induced a marked increase in HB-EGF mRNA levels in rat aortic SMC (11- and 4.6-fold, respectively) that was both dose- and time-dependent.	Tetradecanoylphorbol Acetate	15-51	heparin-binding EGF-like growth factor	Rattus norvegicus	121-127
1447224-3	1992	However, 20 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) and 10(-6) M angiotensin II (AII) induced a marked increase in HB-EGF mRNA levels in rat aortic SMC (11- and 4.6-fold, respectively) that was both dose- and time-dependent.	Tetradecanoylphorbol Acetate	53-56	heparin-binding EGF-like growth factor	Rattus norvegicus	121-127
1447224-4	1992	In response to TPA and AII, HB-EGF mRNA levels increased rapidly, peaked at 2 h, and returned to base line at 7 h. This effect of AII on HB-EGF induction was specific, as evidenced by the fact that it could be completely blocked by the AII antagonist saralasin.	Tetradecanoylphorbol Acetate	15-18	heparin-binding EGF-like growth factor	Rattus norvegicus	28-34
1447224-4	1992	In response to TPA and AII, HB-EGF mRNA levels increased rapidly, peaked at 2 h, and returned to base line at 7 h. This effect of AII on HB-EGF induction was specific, as evidenced by the fact that it could be completely blocked by the AII antagonist saralasin.	Tetradecanoylphorbol Acetate	15-18	angiotensinogen	Rattus norvegicus	130-133
1447224-4	1992	In response to TPA and AII, HB-EGF mRNA levels increased rapidly, peaked at 2 h, and returned to base line at 7 h. This effect of AII on HB-EGF induction was specific, as evidenced by the fact that it could be completely blocked by the AII antagonist saralasin.	Tetradecanoylphorbol Acetate	15-18	heparin-binding EGF-like growth factor	Rattus norvegicus	137-143
1447224-4	1992	In response to TPA and AII, HB-EGF mRNA levels increased rapidly, peaked at 2 h, and returned to base line at 7 h. This effect of AII on HB-EGF induction was specific, as evidenced by the fact that it could be completely blocked by the AII antagonist saralasin.	Tetradecanoylphorbol Acetate	15-18	angiotensinogen	Rattus norvegicus	130-133
1330298-7	1992	The TNF-resistant lines that did not constitutively produce TNF mRNA and protein and the three TNF-sensitive tumor lines exhibited up-regulation of their TNF mRNA in the presence of TNF or phorbol myristate acetate/ionophore, but did not secrete any detectable protein.	Tetradecanoylphorbol Acetate	189-214	tumor necrosis factor	Homo sapiens	4-7
1444457-5	1992	The effects of the inhibitors on some suggested critical steps of the differentiation, a rapid phosphorylation of specific proteins, a rapid membrane association of PKC, and down-regulation of PKC at 18 h after addition of TPA, were not correlated with those on the differentiation marker induction.	Tetradecanoylphorbol Acetate	223-226	protein kinase C alpha	Homo sapiens	193-196
1444457-6	1992	Only the effect of the inhibitors on up-regulation of PKC-alpha was closely correlated with TPA-induced annexin I expression; staurosporine inhibited up-regulation of PKC-alpha but other inhibitors did not similarly affect the induction of annexin I expression.	Tetradecanoylphorbol Acetate	92-95	protein kinase C alpha	Homo sapiens	54-63
1444457-6	1992	Only the effect of the inhibitors on up-regulation of PKC-alpha was closely correlated with TPA-induced annexin I expression; staurosporine inhibited up-regulation of PKC-alpha but other inhibitors did not similarly affect the induction of annexin I expression.	Tetradecanoylphorbol Acetate	92-95	protein kinase C alpha	Homo sapiens	167-176
1444457-7	1992	These results suggest that PKC-alpha is intimately related to macrophage-like differentiation of HL-60 cells by TPA.	Tetradecanoylphorbol Acetate	112-115	protein kinase C alpha	Homo sapiens	27-36
1423314-2	1992	In cells transformed by activated mammalian EJ-ras and chimeric EJ/vHa-ras, high constitutive levels of urokinase plasminogen activator (uPA) mRNA and/or phorbol-12-myristate-13-acetate (PMA) inducibility of the uPA mRNA was observed.	Tetradecanoylphorbol Acetate	187-190	plasminogen activator, urokinase	Homo sapiens	104-135
1332852-6	1992	The increase in both 80K protein phosphorylation and hPL release in response to apoAI was prevented by pretreatment of the cells with the PKC inhibitor staurosporine (10 microM) or by down-regulation of PKC after extended preincubation of the cells with 16 microM PMA.	Tetradecanoylphorbol Acetate	264-267	proline rich transmembrane protein 2	Homo sapiens	138-141
1332852-6	1992	The increase in both 80K protein phosphorylation and hPL release in response to apoAI was prevented by pretreatment of the cells with the PKC inhibitor staurosporine (10 microM) or by down-regulation of PKC after extended preincubation of the cells with 16 microM PMA.	Tetradecanoylphorbol Acetate	264-267	proline rich transmembrane protein 2	Homo sapiens	203-206
1280205-3	1992	The addition of 10(-7) M 4 beta-phorbol 12-myristate 13-acetate (PMA) to HEC-50 and HEC-1B cells resulted in changes in cell morphology, growth inhibition, activation of PKC, and an increase in expression of IGFBP-1.	Tetradecanoylphorbol Acetate	65-68	NDC80 kinetochore complex component	Homo sapiens	84-89
1469290-1	1992	The qualitative and quantitative expression of three calmodulin genes (CAM I, CAM II and CAM III) was characterized in human neonatal melanocytes and metastatic melanoma cell lines in the absence and presence of serum, other growth modulators, and/or 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	251-288	calmodulin 1	Homo sapiens	53-63
1493924-4	1992	Further, 1,25(OH)2D3 inhibited the release of IL-6 in cultures of PHA-activated PBMC, whereas it stimulated IL-6 with the addition of PMA in these cultures.	Tetradecanoylphorbol Acetate	134-137	interleukin 6	Homo sapiens	108-112
1338082-5	1992	TPA and 1-oleoyl-2-acetylglycerol dose-dependently increased the vasopressin-induced arachidonic acid release.	Tetradecanoylphorbol Acetate	0-3	arginine vasopressin	Rattus norvegicus	65-76
1338082-7	1992	TPA increased the vasopressin-stimulated prostaglandin synthesis as well as the arachidonic acid release.	Tetradecanoylphorbol Acetate	0-3	arginine vasopressin	Rattus norvegicus	18-29
1338082-10	1992	TPA alone, added at the late G1 phase, reduced the DNA synthesis stimulated by vasopressin at the G0/G1 phase to about 45%, but vasopressin alone, added at the late G1 phase, had little effect.	Tetradecanoylphorbol Acetate	0-3	arginine vasopressin	Rattus norvegicus	79-90
1469290-1	1992	The qualitative and quantitative expression of three calmodulin genes (CAM I, CAM II and CAM III) was characterized in human neonatal melanocytes and metastatic melanoma cell lines in the absence and presence of serum, other growth modulators, and/or 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	290-293	calmodulin 1	Homo sapiens	53-63
1338082-11	1992	However, with TPA pretreatment, vasopressin significantly suppressed the DNA synthesis by about 70%.	Tetradecanoylphorbol Acetate	14-17	arginine vasopressin	Rattus norvegicus	32-43
1338082-12	1992	Staurosporine, a protein kinase C inhibitor, reduced the suppression by TPA alone or by vasopressin with TPA pretreatment almost to the control level.	Tetradecanoylphorbol Acetate	105-108	arginine vasopressin	Rattus norvegicus	88-99
1469290-7	1992	TPA markedly inhibited expression of all three CaM genes in melanocytes; however, in melanomas the net effect of TPA was to increase their expression.	Tetradecanoylphorbol Acetate	0-3	calmodulin 1	Homo sapiens	47-50
1338082-13	1992	Indomethacin, a cyclo-oxygenase inhibitor, reduced the suppression by vasopressin with TPA pretreatment almost to the level of TPA alone.	Tetradecanoylphorbol Acetate	87-90	arginine vasopressin	Rattus norvegicus	70-81
1469290-7	1992	TPA markedly inhibited expression of all three CaM genes in melanocytes; however, in melanomas the net effect of TPA was to increase their expression.	Tetradecanoylphorbol Acetate	113-116	calmodulin 1	Homo sapiens	47-50
1338082-13	1992	Indomethacin, a cyclo-oxygenase inhibitor, reduced the suppression by vasopressin with TPA pretreatment almost to the level of TPA alone.	Tetradecanoylphorbol Acetate	127-130	arginine vasopressin	Rattus norvegicus	70-81
1330702-4	1992	We show at mRNA and protein levels that TIMP-1 is expressed in differentiated human hepatoma cells (HepG2) and that its synthesis is up-regulated by interleukin-6 (IL-6), transforming growth factor beta 1 and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	209-240	TIMP metallopeptidase inhibitor 1	Homo sapiens	40-46
1464736-5	1992	Treatment of normal monocytes with 12-0-tetradecanoyl phorbol-13-acetate (TPA) for 4-24 h caused the complete disappearance of NF kappa B from nuclear extracts of monocytes.	Tetradecanoylphorbol Acetate	74-77	nuclear factor kappa B subunit 1	Homo sapiens	127-137
1464736-9	1992	In THP-1 cells, TPA also induced a new, faster-migrating NF kappa B species not induced in monocytes.	Tetradecanoylphorbol Acetate	16-19	GLI family zinc finger 2	Homo sapiens	3-8
1464736-9	1992	In THP-1 cells, TPA also induced a new, faster-migrating NF kappa B species not induced in monocytes.	Tetradecanoylphorbol Acetate	16-19	nuclear factor kappa B subunit 1	Homo sapiens	57-67
1279199-5	1992	T cells chronically infected with pol-defective HIV-1 provirus constitutively express both Tat and TNF at levels significantly higher (fivefold) than those seen in control cells, and treatment with phorbol myristate acetate greatly enhances Tat expression and TNF production.	Tetradecanoylphorbol Acetate	198-223	tumor necrosis factor	Homo sapiens	99-102
1279199-5	1992	T cells chronically infected with pol-defective HIV-1 provirus constitutively express both Tat and TNF at levels significantly higher (fivefold) than those seen in control cells, and treatment with phorbol myristate acetate greatly enhances Tat expression and TNF production.	Tetradecanoylphorbol Acetate	198-223	tumor necrosis factor	Homo sapiens	260-263
1491455-2	1992	Cultured rat mesangial cells expressed 2.5 kb TGF-beta mRNA, and removal of fetal calf serum (FCS) for two days decreased the TGF-beta mRNA level, which was then stimulated by addition of 17% FCS and TPA, one of the phorbol esters, although it is also reported by others that the mRNA expression was stimulated by PDGF, EGF, or high glucose.	Tetradecanoylphorbol Acetate	200-203	transforming growth factor, beta 1	Rattus norvegicus	126-134
1301396-2	1992	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) caused the same result as PRL, which suggests that the PRL effect on mAAT activity might be mediated by protein kinase C (PKC) stimulation of pmAAT gene transcription.	Tetradecanoylphorbol Acetate	18-54	prolactin	Sus scrofa	116-119
1301396-2	1992	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) caused the same result as PRL, which suggests that the PRL effect on mAAT activity might be mediated by protein kinase C (PKC) stimulation of pmAAT gene transcription.	Tetradecanoylphorbol Acetate	56-59	prolactin	Sus scrofa	116-119
1283470-2	1992	To modulate this CD4 expression in vitro, pre-incubation with phorbol myristate acetate (PMA) was used.	Tetradecanoylphorbol Acetate	62-87	CD4 molecule	Homo sapiens	17-20
1283470-2	1992	To modulate this CD4 expression in vitro, pre-incubation with phorbol myristate acetate (PMA) was used.	Tetradecanoylphorbol Acetate	89-92	CD4 molecule	Homo sapiens	17-20
1429672-0	1992	Processing and secretion of tumor necrosis factor alpha in endotoxin-treated Mono Mac 6 cells are dependent on phorbol myristate acetate.	Tetradecanoylphorbol Acetate	111-136	tumor necrosis factor	Homo sapiens	28-55
1280163-0	1992	A lymphocyte-specific protein tyrosine kinase, p56lck, regulates the PMA-induced internalization of CD4.	Tetradecanoylphorbol Acetate	69-72	CD4 molecule	Homo sapiens	100-103
1280163-7	1992	Moreover, the dissociation of p56lck from CD4 appeared to occur prior to the PMA-induced internalization of CD4.	Tetradecanoylphorbol Acetate	77-80	CD4 molecule	Homo sapiens	108-111
1358967-8	1992	In functional assays, IL-4 production could only be induced in CD45RA-CD27- CD4 clones by stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	107-110	interleukin 4	Homo sapiens	22-26
1445344-5	1992	IGF-I and EGF stimulated the transcriptional activity dependent on the phorbol 12-myristate 13-acetate-responsive element (TRE) to the same extent, when measured by the chloramphenicol acetyl transferase activity of a transiently transfected multiple TRE construct.	Tetradecanoylphorbol Acetate	71-102	insulin like growth factor 1	Homo sapiens	0-5
1331234-2	1992	Activation of human neutrophils by PMA causes a post-translational incorporation of 14C-labeled tyrosine into multiple neutrophil (PMN) proteins, that is distinctly different from the enzymatic tyrosinolation of tubulin in FMLP-stimulated PMN.	Tetradecanoylphorbol Acetate	35-38	formyl peptide receptor 1	Homo sapiens	223-227
1358967-8	1992	In functional assays, IL-4 production could only be induced in CD45RA-CD27- CD4 clones by stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	107-110	CD4 molecule	Homo sapiens	63-66
1429672-11	1992	Concomitant addition of PMA does not increase TNF alpha mRNA synthesis any further, but it prolongs the half-life of TNF alpha mRNA about 3-fold.	Tetradecanoylphorbol Acetate	24-27	tumor necrosis factor	Homo sapiens	117-126
1331234-4	1992	Similar to the stimulation of PMN tubulin tyrosinolation by FMLP, the PMA-induced incorporation of tyrosine into multiple PMN proteins is closely associated with activation of the NADPH oxidase-mediated respiratory burst in stimulated PMN and can be inhibited by a variety of reducing agents, inhibitors of peroxidase-mediated reactions, and intracellular scavengers of oxygen radicals.	Tetradecanoylphorbol Acetate	70-73	formyl peptide receptor 1	Homo sapiens	60-64
1429672-5	1992	When 30 ng/ml 4-beta-phorbol-12-myristate 13-acetate (PMA) is added together with LPS, large amounts of TNF alpha are secreted.	Tetradecanoylphorbol Acetate	14-52	toll-like receptor 4	Mus musculus	82-85
1429672-5	1992	When 30 ng/ml 4-beta-phorbol-12-myristate 13-acetate (PMA) is added together with LPS, large amounts of TNF alpha are secreted.	Tetradecanoylphorbol Acetate	14-52	tumor necrosis factor	Homo sapiens	104-113
1429672-5	1992	When 30 ng/ml 4-beta-phorbol-12-myristate 13-acetate (PMA) is added together with LPS, large amounts of TNF alpha are secreted.	Tetradecanoylphorbol Acetate	54-57	tumor necrosis factor	Homo sapiens	104-113
1279983-7	1992	Phorbol 12-myristate 13-acetate-stimulated neutrophil adherence was significantly attenuated by MAb IB4, indicating that CD11/CD18 participates in this adhesion process.	Tetradecanoylphorbol Acetate	0-31	integrin subunit beta 2	Homo sapiens	126-130
1363506-5	1992	U937 cells exposed to retinoic acid (RA) for 4 days or to phorbol myristate acetate (PMA) for 2 days acquired characteristics of macrophages, including the capacity to produce superoxide (O2-), responsiveness to formyl-methionyl-leucyl-phenylalanine (fMLP) and reduced proliferation.	Tetradecanoylphorbol Acetate	58-83	formyl peptide receptor 1	Homo sapiens	251-255
1363506-5	1992	U937 cells exposed to retinoic acid (RA) for 4 days or to phorbol myristate acetate (PMA) for 2 days acquired characteristics of macrophages, including the capacity to produce superoxide (O2-), responsiveness to formyl-methionyl-leucyl-phenylalanine (fMLP) and reduced proliferation.	Tetradecanoylphorbol Acetate	85-88	formyl peptide receptor 1	Homo sapiens	251-255
1394868-3	1992	On the other hand, endothelin (10(-7) M, +57%) and TPA (10(-6) M, +55%) (p < 0.01 each) increased the secretion of BNP in a dose-dependent manner, whereas A23187 (10(-6) M, -45%, p < 0.001) suppressed the secretion of BNP in a dose-dependent manner, and Bay K 8644 caused no significant effects on BNP secretion.	Tetradecanoylphorbol Acetate	51-54	natriuretic peptide B	Rattus norvegicus	118-121
1445248-3	1992	Short-term preincubation of cells with the phorbol ester 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA), which activates protein kinase C (PKC), blocked the increase in [Ca2+]i induced by TLC, but did not alter that mediated by vasopressin.	Tetradecanoylphorbol Acetate	108-111	arginine vasopressin	Rattus norvegicus	237-248
1467312-4	1992	The addition of 10(-7) M 4 beta-phorbol 12-myristate 13-acetate (PMA) to HEC-50 and HEC-1B cell cultures resulted in a change in cell morphology, an inhibition of proliferation, an increase in calcyclin transcription rate, and an increase in calcyclin mRNA and calcyclin protein levels.	Tetradecanoylphorbol Acetate	25-63	S100 calcium binding protein A6	Homo sapiens	193-202
1467312-4	1992	The addition of 10(-7) M 4 beta-phorbol 12-myristate 13-acetate (PMA) to HEC-50 and HEC-1B cell cultures resulted in a change in cell morphology, an inhibition of proliferation, an increase in calcyclin transcription rate, and an increase in calcyclin mRNA and calcyclin protein levels.	Tetradecanoylphorbol Acetate	25-63	S100 calcium binding protein A6	Homo sapiens	242-251
1467312-4	1992	The addition of 10(-7) M 4 beta-phorbol 12-myristate 13-acetate (PMA) to HEC-50 and HEC-1B cell cultures resulted in a change in cell morphology, an inhibition of proliferation, an increase in calcyclin transcription rate, and an increase in calcyclin mRNA and calcyclin protein levels.	Tetradecanoylphorbol Acetate	25-63	S100 calcium binding protein A6	Homo sapiens	242-251
1467312-4	1992	The addition of 10(-7) M 4 beta-phorbol 12-myristate 13-acetate (PMA) to HEC-50 and HEC-1B cell cultures resulted in a change in cell morphology, an inhibition of proliferation, an increase in calcyclin transcription rate, and an increase in calcyclin mRNA and calcyclin protein levels.	Tetradecanoylphorbol Acetate	65-68	S100 calcium binding protein A6	Homo sapiens	193-202
1467312-4	1992	The addition of 10(-7) M 4 beta-phorbol 12-myristate 13-acetate (PMA) to HEC-50 and HEC-1B cell cultures resulted in a change in cell morphology, an inhibition of proliferation, an increase in calcyclin transcription rate, and an increase in calcyclin mRNA and calcyclin protein levels.	Tetradecanoylphorbol Acetate	65-68	S100 calcium binding protein A6	Homo sapiens	242-251
1467312-4	1992	The addition of 10(-7) M 4 beta-phorbol 12-myristate 13-acetate (PMA) to HEC-50 and HEC-1B cell cultures resulted in a change in cell morphology, an inhibition of proliferation, an increase in calcyclin transcription rate, and an increase in calcyclin mRNA and calcyclin protein levels.	Tetradecanoylphorbol Acetate	65-68	S100 calcium binding protein A6	Homo sapiens	242-251
1394868-3	1992	On the other hand, endothelin (10(-7) M, +57%) and TPA (10(-6) M, +55%) (p < 0.01 each) increased the secretion of BNP in a dose-dependent manner, whereas A23187 (10(-6) M, -45%, p < 0.001) suppressed the secretion of BNP in a dose-dependent manner, and Bay K 8644 caused no significant effects on BNP secretion.	Tetradecanoylphorbol Acetate	51-54	natriuretic peptide B	Rattus norvegicus	224-227
1394868-3	1992	On the other hand, endothelin (10(-7) M, +57%) and TPA (10(-6) M, +55%) (p < 0.01 each) increased the secretion of BNP in a dose-dependent manner, whereas A23187 (10(-6) M, -45%, p < 0.001) suppressed the secretion of BNP in a dose-dependent manner, and Bay K 8644 caused no significant effects on BNP secretion.	Tetradecanoylphorbol Acetate	51-54	natriuretic peptide B	Rattus norvegicus	224-227
1330500-12	1992	The stimulation of cAMP by AII was mimicked by 10-min incubation with phorbol 12-myristate 13-acetate (PMA), and prevented after cellular protein kinase-C (PKC) depletion by 4- or 6-h preincubation with PMA.	Tetradecanoylphorbol Acetate	70-101	angiotensinogen	Rattus norvegicus	27-30
1330491-10	1992	c-fos mRNA was induced by treatment with 50 ng/ml tetradecanoyl phorbol acetate or by 40 ng/ml forskolin, while induction of Egr-1 mRNA was stimulated by treatment with tetradecanoyl phorbol acetate, but not forskolin.	Tetradecanoylphorbol Acetate	169-198	early growth response 1	Rattus norvegicus	125-130
1292632-3	1992	After stimulation with phorbol myristate acetate LC express RNA for interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta) and produce proteins but do not secrete them at detectable levels.	Tetradecanoylphorbol Acetate	23-48	interleukin 1 beta	Homo sapiens	105-123
1292632-3	1992	After stimulation with phorbol myristate acetate LC express RNA for interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta) and produce proteins but do not secrete them at detectable levels.	Tetradecanoylphorbol Acetate	23-48	interleukin 1 beta	Homo sapiens	125-134
1330500-12	1992	The stimulation of cAMP by AII was mimicked by 10-min incubation with phorbol 12-myristate 13-acetate (PMA), and prevented after cellular protein kinase-C (PKC) depletion by 4- or 6-h preincubation with PMA.	Tetradecanoylphorbol Acetate	103-106	angiotensinogen	Rattus norvegicus	27-30
1330500-12	1992	The stimulation of cAMP by AII was mimicked by 10-min incubation with phorbol 12-myristate 13-acetate (PMA), and prevented after cellular protein kinase-C (PKC) depletion by 4- or 6-h preincubation with PMA.	Tetradecanoylphorbol Acetate	203-206	angiotensinogen	Rattus norvegicus	27-30
1337986-3	1992	Our data show a definite downregulation of IL-6R and gp130 expression by TPA in U266 and BMNH at both mRNA and cell surface protein levels.	Tetradecanoylphorbol Acetate	73-76	interleukin 6 receptor	Homo sapiens	43-48
1358626-3	1992	As tested by immunofluorescence, neutrophil CD43 membrane expression was shown to decrease by up to 80% upon cell activation by phorbol myristate acetate (10 ng/ml) or by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP; 10(-6) M) in the presence of cytochalasin B.	Tetradecanoylphorbol Acetate	128-153	sialophorin	Homo sapiens	44-48
1337986-4	1992	In U937 TPA inhibits only the IL-6R expression, without affecting that of gp130.	Tetradecanoylphorbol Acetate	8-11	interleukin 6 receptor	Homo sapiens	30-35
1425422-3	1992	Induction of acrosome reaction by 12-O-tetradecanoyl phorbol-13-acetate was blocked by the PKC inhibitor staurosporine or by down-regulation of endogenous PKC, but not by removal of extracellular Ca2+.	Tetradecanoylphorbol Acetate	34-71	proline rich transmembrane protein 2	Homo sapiens	91-94
1425422-3	1992	Induction of acrosome reaction by 12-O-tetradecanoyl phorbol-13-acetate was blocked by the PKC inhibitor staurosporine or by down-regulation of endogenous PKC, but not by removal of extracellular Ca2+.	Tetradecanoylphorbol Acetate	34-71	proline rich transmembrane protein 2	Homo sapiens	155-158
1425916-8	1992	Rather, PMA blocked the IL-3 effect on C5a-induced LTC4 synthesis.	Tetradecanoylphorbol Acetate	8-11	complement C5a receptor 1	Homo sapiens	39-42
1358626-3	1992	As tested by immunofluorescence, neutrophil CD43 membrane expression was shown to decrease by up to 80% upon cell activation by phorbol myristate acetate (10 ng/ml) or by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP; 10(-6) M) in the presence of cytochalasin B.	Tetradecanoylphorbol Acetate	128-153	formyl peptide receptor 1	Homo sapiens	218-222
1335962-5	1992	Induction of cytoplasmic ACTH-IR was maximal within 6 hr of stimulation with CRF/AVP or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	88-113	proopiomelanocortin	Homo sapiens	25-29
1459477-0	1992	The inhibitory effects of 21 mimics of superoxide dismutase on luminol-mediated chemiluminescence emitted from PMA-stimulated polymorphonuclear leukocyte.	Tetradecanoylphorbol Acetate	111-114	superoxide dismutase 1	Homo sapiens	39-59
1459477-1	1992	Four groups comprising 21 superoxide dismutase (SOD) mimics synthesized by us were comparatively studied for their inhibitory effects on luminol-mediated chemiluminescence emitted from phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocyte (PMNL).	Tetradecanoylphorbol Acetate	185-210	superoxide dismutase 1	Homo sapiens	26-46
1459477-1	1992	Four groups comprising 21 superoxide dismutase (SOD) mimics synthesized by us were comparatively studied for their inhibitory effects on luminol-mediated chemiluminescence emitted from phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocyte (PMNL).	Tetradecanoylphorbol Acetate	185-210	superoxide dismutase 1	Homo sapiens	48-51
1459477-1	1992	Four groups comprising 21 superoxide dismutase (SOD) mimics synthesized by us were comparatively studied for their inhibitory effects on luminol-mediated chemiluminescence emitted from phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocyte (PMNL).	Tetradecanoylphorbol Acetate	212-215	superoxide dismutase 1	Homo sapiens	26-46
1459477-1	1992	Four groups comprising 21 superoxide dismutase (SOD) mimics synthesized by us were comparatively studied for their inhibitory effects on luminol-mediated chemiluminescence emitted from phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocyte (PMNL).	Tetradecanoylphorbol Acetate	212-215	superoxide dismutase 1	Homo sapiens	48-51
1334475-2	1992	Preincubation of PMNs with n-TNF for 3 min increased PMN-derived superoxide generation induced by phorbol myristate acetate, A23187, opsonized zymosan and N-formyl-methionyl-leucyl-phenylalanine in a concentration dependent manner (0.5-50 Japan reference units/ml of n-TNF).	Tetradecanoylphorbol Acetate	98-123	tumor necrosis factor	Homo sapiens	29-32
1335962-5	1992	Induction of cytoplasmic ACTH-IR was maximal within 6 hr of stimulation with CRF/AVP or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	115-118	proopiomelanocortin	Homo sapiens	25-29
1430083-4	1992	Phorbol myristate acetate, a protein kinase C activator, dose-dependently increased the release of ET-1-LI from the decidual cells, while a protein kinase C inhibitor, H7, significantly attenuated the stimulatory effect of phorbol myristate acetate on ET-1-LI release.	Tetradecanoylphorbol Acetate	0-25	endothelin 1	Homo sapiens	99-103
1428115-7	1992	Phorbol 12-myristate 13-acetate-induced phosphorylation of pp42 indicates the possibility of an association between protein kinase C and the signal transduction pathway of angiotensin II-induced pp42 phosphorylation.	Tetradecanoylphorbol Acetate	0-31	angiotensinogen	Rattus norvegicus	172-186
1331177-5	1992	In human corticotrophic adenoma cells, basal IL-2 mRNA expression as well as IL-2 secretion were further stimulated by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	119-144	interleukin 2	Homo sapiens	45-49
1331177-5	1992	In human corticotrophic adenoma cells, basal IL-2 mRNA expression as well as IL-2 secretion were further stimulated by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	119-144	interleukin 2	Homo sapiens	77-81
1430083-4	1992	Phorbol myristate acetate, a protein kinase C activator, dose-dependently increased the release of ET-1-LI from the decidual cells, while a protein kinase C inhibitor, H7, significantly attenuated the stimulatory effect of phorbol myristate acetate on ET-1-LI release.	Tetradecanoylphorbol Acetate	0-25	endothelin 1	Homo sapiens	252-267
1430083-4	1992	Phorbol myristate acetate, a protein kinase C activator, dose-dependently increased the release of ET-1-LI from the decidual cells, while a protein kinase C inhibitor, H7, significantly attenuated the stimulatory effect of phorbol myristate acetate on ET-1-LI release.	Tetradecanoylphorbol Acetate	223-248	endothelin 1	Homo sapiens	99-103
1430083-4	1992	Phorbol myristate acetate, a protein kinase C activator, dose-dependently increased the release of ET-1-LI from the decidual cells, while a protein kinase C inhibitor, H7, significantly attenuated the stimulatory effect of phorbol myristate acetate on ET-1-LI release.	Tetradecanoylphorbol Acetate	223-248	endothelin 1	Homo sapiens	252-267
1417981-6	1992	While TPA treatment was associated with transient increases in NF-kappa B mRNA levels, this induction was blocked by dexamethasone.	Tetradecanoylphorbol Acetate	6-9	nuclear factor kappa B subunit 1	Homo sapiens	63-73
1290964-3	1992	We found that GM-CSFR beta-subunit mRNA was expressed constitutively in CMK cells and was transiently down-regulated by TPA and IL-6, while the expression of IL-6R mRNA was increased by TPA in association with the differentiation of megakaryocytes.	Tetradecanoylphorbol Acetate	186-189	interleukin 6 receptor	Homo sapiens	158-163
1437150-6	1992	Proteolytic down-regulation of membrane-bound PKC was enhanced in T-12 cells compared with the initiated cells after 3 h of TPA treatment.	Tetradecanoylphorbol Acetate	124-127	proline rich transmembrane protein 2	Homo sapiens	46-49
1282723-3	1992	The TNF-alpha-stimulated ICAM-1 expression is resistant however to downregulation of PKC with PMA.	Tetradecanoylphorbol Acetate	94-97	tumor necrosis factor	Mus musculus	4-13
1400474-1	1992	Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) was compared with calcium/phosphatidylserine (Ca/PS).	Tetradecanoylphorbol Acetate	40-71	protein kinase C alpha	Homo sapiens	32-35
1400474-1	1992	Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) was compared with calcium/phosphatidylserine (Ca/PS).	Tetradecanoylphorbol Acetate	73-76	protein kinase C alpha	Homo sapiens	32-35
1400474-7	1992	Differential substrate phosphorylation by PS/PMA also occurred for PKC isozymes resolved by hydroxylapatite chromatography and was most dramatic for PKC-alpha, which could no longer phosphorylate histone or GS1-12.	Tetradecanoylphorbol Acetate	45-48	protein kinase C alpha	Homo sapiens	67-70
1400474-7	1992	Differential substrate phosphorylation by PS/PMA also occurred for PKC isozymes resolved by hydroxylapatite chromatography and was most dramatic for PKC-alpha, which could no longer phosphorylate histone or GS1-12.	Tetradecanoylphorbol Acetate	45-48	protein kinase C alpha	Homo sapiens	149-158
1400474-8	1992	Differential activities of PKC were also observed in synaptosol and in intact synaptosomes where PMA stimulated phosphorylation of MARCKS, but not dephosphin.	Tetradecanoylphorbol Acetate	97-100	protein kinase C alpha	Homo sapiens	27-30
1400499-0	1992	Distal AP-1 binding sites mediate basal level enhancement and TPA induction of the mouse heme oxygenase-1 gene.	Tetradecanoylphorbol Acetate	62-65	heme oxygenase 1	Mus musculus	89-105
1417980-10	1992	We suggest that the inhibition of thymocyte proliferation by staurosporine results from inhibition of both protein kinase C and tyrosine kinase: the augmentation of the response to A23187 and TPA results from inhibition of protein kinase C. Inhibition of signal transduction as well as inhibition of IL-2-driven mitogenesis result from inhibition of tyrosine kinase.	Tetradecanoylphorbol Acetate	192-195	interleukin 2	Homo sapiens	300-304
1417981-1	1992	The treatment of human myeloid leukemia cells (HL-60, U-937, THP-1) with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with growth arrest and appearance of a differentiated monocytic phenotype.	Tetradecanoylphorbol Acetate	73-109	GLI family zinc finger 2	Homo sapiens	61-66
1417981-1	1992	The treatment of human myeloid leukemia cells (HL-60, U-937, THP-1) with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with growth arrest and appearance of a differentiated monocytic phenotype.	Tetradecanoylphorbol Acetate	111-114	GLI family zinc finger 2	Homo sapiens	61-66
1327540-7	1992	Twenty-four hours after treatment with TNF the O2- release was measured spectrophotometrically following exposure to PMA.	Tetradecanoylphorbol Acetate	117-120	tumor necrosis factor	Homo sapiens	39-42
1417981-8	1992	Taken together, these findings suggest that the activated glucocorticoid receptor inhibits signaling pathways which include expression of the EGR-1 and NF-kappa B genes and that such effects may contribute to a block in TPA-induced monocytic differentiation.	Tetradecanoylphorbol Acetate	220-223	nuclear receptor subfamily 3 group C member 1	Homo sapiens	58-81
1417981-8	1992	Taken together, these findings suggest that the activated glucocorticoid receptor inhibits signaling pathways which include expression of the EGR-1 and NF-kappa B genes and that such effects may contribute to a block in TPA-induced monocytic differentiation.	Tetradecanoylphorbol Acetate	220-223	nuclear factor kappa B subunit 1	Homo sapiens	152-162
1357985-7	1992	To directly investigate the role of PKC in ICAM-1 induction, we downregulated PKC by pretreatment of human umbilical vein endothelial cells with phorbol 12-myristate 13-acetate (PMA) and assessed ICAM-1 protein and mRNA induction elicited by subsequent exposure to inflammatory stimuli.	Tetradecanoylphorbol Acetate	145-176	proline rich transmembrane protein 2	Homo sapiens	78-81
1390899-5	1992	TPA increased TGF-beta activity in MCF-7 conditioned medium.	Tetradecanoylphorbol Acetate	0-3	transforming growth factor beta 1	Homo sapiens	14-22
1390899-7	1992	TPA induced a dose-dependent increase in TGF-beta 1 mRNA levels that paralleled the inhibitory effect on MCF-7 proliferation.	Tetradecanoylphorbol Acetate	0-3	transforming growth factor beta 1	Homo sapiens	41-51
1390899-8	1992	The lower level of TGF-beta mRNA expression in TPA resistant subline was not modified after addition of TPA, but was significantly increased in the presence of exogenous TGF-beta 1.	Tetradecanoylphorbol Acetate	47-50	transforming growth factor beta 1	Homo sapiens	19-27
1390899-8	1992	The lower level of TGF-beta mRNA expression in TPA resistant subline was not modified after addition of TPA, but was significantly increased in the presence of exogenous TGF-beta 1.	Tetradecanoylphorbol Acetate	47-50	transforming growth factor beta 1	Homo sapiens	170-180
1390899-8	1992	The lower level of TGF-beta mRNA expression in TPA resistant subline was not modified after addition of TPA, but was significantly increased in the presence of exogenous TGF-beta 1.	Tetradecanoylphorbol Acetate	104-107	transforming growth factor beta 1	Homo sapiens	19-27
1327012-0	1992	Tumor necrosis factor-alpha and interleukin-1 alpha synergistically enhance phorbol myristate acetate-induced superoxide production by rat bone marrow-derived macrophages.	Tetradecanoylphorbol Acetate	76-101	tumor necrosis factor	Rattus norvegicus	0-27
1327012-0	1992	Tumor necrosis factor-alpha and interleukin-1 alpha synergistically enhance phorbol myristate acetate-induced superoxide production by rat bone marrow-derived macrophages.	Tetradecanoylphorbol Acetate	76-101	interleukin 1 alpha	Rattus norvegicus	32-51
1327012-6	1992	The biologic response to TNF-alpha and IL-1 alpha was assessed by measurement of superoxide production quantitated by the reduction of cytochrome c in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	163-188	tumor necrosis factor	Rattus norvegicus	25-34
1327012-6	1992	The biologic response to TNF-alpha and IL-1 alpha was assessed by measurement of superoxide production quantitated by the reduction of cytochrome c in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	163-188	interleukin 1 alpha	Rattus norvegicus	39-49
1384479-5	1992	The tumor promoter, tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the stimulatory effect of IL-1 alpha and IL-1 beta on the production of HGF.	Tetradecanoylphorbol Acetate	53-56	interleukin 1 beta	Homo sapiens	117-126
1384479-6	1992	The stimulatory effect of both IL-1 alpha and IL-1 beta and the synergistical stimulation with TPA were completely abrogated by 10 ng/ml TGF-beta 1 or 1 microM dexamethasone.	Tetradecanoylphorbol Acetate	95-98	transforming growth factor beta 1	Homo sapiens	137-147
1394146-4	1992	S49.1 and WEHI7.2 cells infected with bcl-2 but not control retrovirus also exhibited increased resistance to cell killing and DNA fragmentation induced by a wide variety of reagents, including the calcium ionophore ionomycin, the phorbol ester tetradecanoylphorbol acetate, the dihydrofolate reductase inhibitor methotrexate, the antimetabolite 1-beta-D-arabinofuranosylcytosine, and the microtubule inhibitor vincristine.	Tetradecanoylphorbol Acetate	245-273	B cell leukemia/lymphoma 2	Mus musculus	38-43
1384908-8	1992	In Ca(2+)-free Krebs containing 1 mM EGTA, precontraction with 10(-6) M TPA potentiated the contractile response to subsequently added 10(-8) M ET-1, whereas this potentiation was abolished by pretreatment with 10(-6) M calphostin C.	Tetradecanoylphorbol Acetate	72-75	endothelin 1	Rattus norvegicus	144-148
1445798-4	1992	junB and fosB were rapidly induced following stimulation with TPA.	Tetradecanoylphorbol Acetate	62-65	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
1445798-6	1992	The expression of fos and jun during T-cell activation was accompanied by increased specific binding of JunB, FosB, and fos-related antigen containing complexes to the TPA responsive element.	Tetradecanoylphorbol Acetate	168-171	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-108
1394441-3	1992	After stimulation with phytohemagglutinin (PHA) and phorbol myristate acetate (PMA), Tat transfectants with high Tat expression showed diminished expression of interleukin-2 (IL-2) and the interleukin-2 receptor alpha chain (IL-2R) when compared to untransfected Jurkat cells or Jurkat cell lines transfected with the parent control plasmid.	Tetradecanoylphorbol Acetate	52-77	interleukin 2	Homo sapiens	160-173
1445803-1	1992	To study the signal transduction pathway leading to phorbol 12-myristate 13-acetate (PMA)-induced differentiation in human promyelocytic HL-60 leukemia cells, we examined the expression of protein kinase C (PKC) isozyme genes in HL-60 cells that are susceptible or resistant to PMA-induced differentiation.	Tetradecanoylphorbol Acetate	52-83	protein kinase C alpha	Homo sapiens	207-210
1394441-3	1992	After stimulation with phytohemagglutinin (PHA) and phorbol myristate acetate (PMA), Tat transfectants with high Tat expression showed diminished expression of interleukin-2 (IL-2) and the interleukin-2 receptor alpha chain (IL-2R) when compared to untransfected Jurkat cells or Jurkat cell lines transfected with the parent control plasmid.	Tetradecanoylphorbol Acetate	52-77	interleukin 2	Homo sapiens	175-179
1394441-3	1992	After stimulation with phytohemagglutinin (PHA) and phorbol myristate acetate (PMA), Tat transfectants with high Tat expression showed diminished expression of interleukin-2 (IL-2) and the interleukin-2 receptor alpha chain (IL-2R) when compared to untransfected Jurkat cells or Jurkat cell lines transfected with the parent control plasmid.	Tetradecanoylphorbol Acetate	52-77	interleukin 2	Homo sapiens	189-202
1445803-1	1992	To study the signal transduction pathway leading to phorbol 12-myristate 13-acetate (PMA)-induced differentiation in human promyelocytic HL-60 leukemia cells, we examined the expression of protein kinase C (PKC) isozyme genes in HL-60 cells that are susceptible or resistant to PMA-induced differentiation.	Tetradecanoylphorbol Acetate	85-88	protein kinase C alpha	Homo sapiens	207-210
1445803-1	1992	To study the signal transduction pathway leading to phorbol 12-myristate 13-acetate (PMA)-induced differentiation in human promyelocytic HL-60 leukemia cells, we examined the expression of protein kinase C (PKC) isozyme genes in HL-60 cells that are susceptible or resistant to PMA-induced differentiation.	Tetradecanoylphorbol Acetate	278-281	protein kinase C alpha	Homo sapiens	207-210
1396721-4	1992	Translocation assays based upon phosphorylation of the 35-kDa protein and Western blotting techniques allowed the movement of PKC from the cytosolic to the particulate fraction in response to PMA and CAF to be detected but not in response to 4 alpha-PMA or hrIL-1.	Tetradecanoylphorbol Acetate	192-195	proline rich transmembrane protein 2	Homo sapiens	126-129
1382961-2	1992	Treatment of MCF-7 cells, a human mammary adenocarcinoma cell line, with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (10-7 M) was associated with a time-dependent reduction in the level of estrogen receptor (ER) mRNA (half-life approximately 3 h).	Tetradecanoylphorbol Acetate	91-127	estrogen receptor 1	Homo sapiens	206-223
1382961-2	1992	Treatment of MCF-7 cells, a human mammary adenocarcinoma cell line, with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (10-7 M) was associated with a time-dependent reduction in the level of estrogen receptor (ER) mRNA (half-life approximately 3 h).	Tetradecanoylphorbol Acetate	91-127	estrogen receptor 1	Homo sapiens	225-227
1382961-2	1992	Treatment of MCF-7 cells, a human mammary adenocarcinoma cell line, with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (10-7 M) was associated with a time-dependent reduction in the level of estrogen receptor (ER) mRNA (half-life approximately 3 h).	Tetradecanoylphorbol Acetate	129-132	estrogen receptor 1	Homo sapiens	206-223
1396321-9	1992	Both desensitization to PTH and receptor down-regulation were induced, however, by pretreatment with a phorbol ester (12-O-tetradecanoyl phorbol-13-acetate), and these effects were blocked completely by staurosporine.	Tetradecanoylphorbol Acetate	118-155	parathyroid hormone	Homo sapiens	24-40
1382961-2	1992	Treatment of MCF-7 cells, a human mammary adenocarcinoma cell line, with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (10-7 M) was associated with a time-dependent reduction in the level of estrogen receptor (ER) mRNA (half-life approximately 3 h).	Tetradecanoylphorbol Acetate	129-132	estrogen receptor 1	Homo sapiens	225-227
1440503-3	1992	Two agents were identified, Zn2+ and phorbol myristate acetate (PMA), which support progressive decreases in bound fibrinogen expression on platelets, but fail to support the stabilization of fibrinogen binding.	Tetradecanoylphorbol Acetate	37-62	fibrinogen beta chain	Homo sapiens	115-125
1382961-4	1992	Furthermore, the TPA-dependent down-regulation of ER mRNA was abolished by actinomycin D.	Tetradecanoylphorbol Acetate	17-20	estrogen receptor 1	Homo sapiens	50-52
1382961-7	1992	Our studies show that degradation of ER mRNA by TPA in MCF-7 cells is dependent on ongoing RNA synthesis but not on protein synthesis.	Tetradecanoylphorbol Acetate	48-51	estrogen receptor 1	Homo sapiens	37-39
1382961-8	1992	This indicates that an RNA molecule with rapid turnover, which does not require translation, might be involved in the TPA-dependent ER mRNA decay.	Tetradecanoylphorbol Acetate	118-121	estrogen receptor 1	Homo sapiens	132-134
1397084-0	1992	Cytochalasans and PMA induce IL-2 receptors on CD8+ lymphocytes.	Tetradecanoylphorbol Acetate	18-21	interleukin 2	Homo sapiens	29-33
1406637-2	1992	In addition, phorbol esters may promote cell growth by the inhibition of expression of cellular gene products regulated by antiproliferative agents such as interferons (IFN)s. In human diploid fibroblasts, phorbol 12-myristate 13-acetate (PMA) selectively inhibits the IFN-alpha-induced cellular gene ISG54.	Tetradecanoylphorbol Acetate	206-237	interferon alpha 1	Homo sapiens	269-278
1530652-1	1992	A strong enhancer element, GPEI, of the glutathione transferase P gene (GST-P) gene is composed of two phorbol 12-O-tetradecanoate 13-acetate (TPA) responsive element (TRE)-like sequences at opposite orientation.	Tetradecanoylphorbol Acetate	143-146	glutathione S-transferase pi 1	Rattus norvegicus	72-77
1530652-3	1992	GPEI bound to AP-1 In vitro and GST-P expression was activated by TPA and exogenously introduced c-jun gene in a rat fibroblast cell line.	Tetradecanoylphorbol Acetate	66-69	glutathione S-transferase pi 1	Rattus norvegicus	32-37
1530652-4	1992	Both the stimulated expression of GST-P gene by TPA and that by over-expressed c-Jun were suppressed to the basal level by dexamethasone, an inhibitor of AP-1.	Tetradecanoylphorbol Acetate	48-51	glutathione S-transferase pi 1	Rattus norvegicus	34-39
1325443-1	1992	v-Src activates promoters under the control of 12-O-tetradecanoylphorbol-13-acetate (TPA) response elements (TREs) and serum response elements (SREs) via two distinguishable intracellular signaling mechanisms.	Tetradecanoylphorbol Acetate	47-83	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	2-5
1325443-1	1992	v-Src activates promoters under the control of 12-O-tetradecanoylphorbol-13-acetate (TPA) response elements (TREs) and serum response elements (SREs) via two distinguishable intracellular signaling mechanisms.	Tetradecanoylphorbol Acetate	85-88	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	2-5
1440503-8	1992	Costimulation of PMA- or Zn(2+)-treated platelets with low doses of A23187, however, restored the stabilization of platelet-fibrinogen interactions.	Tetradecanoylphorbol Acetate	17-20	fibrinogen beta chain	Homo sapiens	124-134
1505676-4	1992	In this study, we utilized primer extension analysis to evaluate the tPA mRNA start site in phorbol-12-myristate 13-acetate (PMA) induced WI-38 human lung fibroblast cells.	Tetradecanoylphorbol Acetate	92-123	plasminogen activator, tissue type	Homo sapiens	69-72
1505676-4	1992	In this study, we utilized primer extension analysis to evaluate the tPA mRNA start site in phorbol-12-myristate 13-acetate (PMA) induced WI-38 human lung fibroblast cells.	Tetradecanoylphorbol Acetate	125-128	plasminogen activator, tissue type	Homo sapiens	69-72
1355672-8	1992	FMLP-induced neutrophil aggregation was inhibited by 39.8% +/- 11.5% and 44.8% +/- 12.3%, respectively, by MoAbs to CD18 and CD11b (P less than .0005, n = 4 for both); a similar effect was demonstrated on TPA-induced aggregation.	Tetradecanoylphorbol Acetate	205-208	formyl peptide receptor 1	Homo sapiens	0-4
1355672-8	1992	FMLP-induced neutrophil aggregation was inhibited by 39.8% +/- 11.5% and 44.8% +/- 12.3%, respectively, by MoAbs to CD18 and CD11b (P less than .0005, n = 4 for both); a similar effect was demonstrated on TPA-induced aggregation.	Tetradecanoylphorbol Acetate	205-208	integrin subunit beta 2	Homo sapiens	116-120
1381351-6	1992	In the present study, we find dose-dependent up-regulation of CD34 surface expression following treatment of normal human CD34+ bone marrow progenitor cells, cord blood-derived KMT-2, or KG1 a myeloid leukemia cells with the PKC activator 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	239-275	CD34 molecule	Homo sapiens	62-66
1440503-3	1992	Two agents were identified, Zn2+ and phorbol myristate acetate (PMA), which support progressive decreases in bound fibrinogen expression on platelets, but fail to support the stabilization of fibrinogen binding.	Tetradecanoylphorbol Acetate	64-67	fibrinogen beta chain	Homo sapiens	115-125
1440503-4	1992	Sixty min after binding to platelets, approximately 80% of bound fibrinogen remained reversibly associated with Zn(2+)- or PMA-treated platelets and failed to associate with the Triton X-100 insoluble cytoskeleton.	Tetradecanoylphorbol Acetate	123-126	fibrinogen beta chain	Homo sapiens	65-75
1330154-11	1992	Preincubation with the PKC inhibitor Ro-31-8220 abolished both TPA- and vasopressin-stimulated [3H]-PtdBuOH, suggesting that the intermediate activation of protein kinase C is involved in the regulation of PLD by vasopressin.	Tetradecanoylphorbol Acetate	63-66	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	206-209
1325212-3	1992	To date, IL-10 expression has been described in several T clones induced with anti-CD3 and phorbol myristate acetate (PMA), in monocytes stimulated with lipopolysaccharide (LPS), and in murine B-cell lymphomas.	Tetradecanoylphorbol Acetate	91-116	interleukin 10	Mus musculus	9-14
1325212-3	1992	To date, IL-10 expression has been described in several T clones induced with anti-CD3 and phorbol myristate acetate (PMA), in monocytes stimulated with lipopolysaccharide (LPS), and in murine B-cell lymphomas.	Tetradecanoylphorbol Acetate	118-121	interleukin 10	Mus musculus	9-14
1530595-2	1992	Either elevation of intracellular Ca2+ concentration ([Ca2+]i) with a Ca2+ ionophore or activation of protein kinase (PK) C by phorbol 12-myristate 13-acetate caused vWf secretion, and together the agents acted synergistically.	Tetradecanoylphorbol Acetate	127-158	von Willebrand factor	Homo sapiens	166-169
1330154-11	1992	Preincubation with the PKC inhibitor Ro-31-8220 abolished both TPA- and vasopressin-stimulated [3H]-PtdBuOH, suggesting that the intermediate activation of protein kinase C is involved in the regulation of PLD by vasopressin.	Tetradecanoylphorbol Acetate	63-66	arginine vasopressin	Homo sapiens	213-224
1423659-4	1992	Phorbol 12-myristate 13-acetate-induced secretion of hHGF from human skin fibroblasts was also suppressed by TGF-beta 1.	Tetradecanoylphorbol Acetate	0-31	transforming growth factor beta 1	Homo sapiens	109-119
1379986-7	1992	LPS was found to inhibit thymocyte proliferation stimulated by concanavalin A or the combination of phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	100-125	toll-like receptor 4	Mus musculus	0-3
1419487-1	1992	The addition of granulocyte-macrophage colony-stimulating factor (GM-CSF) to human peripheral blood neutrophils primes phospholipase D (PLD) to subsequent stimulation by N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	220-245	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-134
1419487-1	1992	The addition of granulocyte-macrophage colony-stimulating factor (GM-CSF) to human peripheral blood neutrophils primes phospholipase D (PLD) to subsequent stimulation by N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	220-245	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	136-139
1419487-1	1992	The addition of granulocyte-macrophage colony-stimulating factor (GM-CSF) to human peripheral blood neutrophils primes phospholipase D (PLD) to subsequent stimulation by N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	247-250	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-134
1419487-1	1992	The addition of granulocyte-macrophage colony-stimulating factor (GM-CSF) to human peripheral blood neutrophils primes phospholipase D (PLD) to subsequent stimulation by N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	247-250	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	136-139
1356913-5	1992	Here we show that Thy-1-enriched IEL are not an immunocompromised population of cells but are functionally competent T cells that are capable of proliferation and lymphokine secretion after stimulation with concanavalin A (Con A), phorbol myristate acetate (PMA) and anti-CD3 monoclonal antibody (mAb).	Tetradecanoylphorbol Acetate	231-256	thymus cell antigen 1, theta	Mus musculus	18-23
1356913-5	1992	Here we show that Thy-1-enriched IEL are not an immunocompromised population of cells but are functionally competent T cells that are capable of proliferation and lymphokine secretion after stimulation with concanavalin A (Con A), phorbol myristate acetate (PMA) and anti-CD3 monoclonal antibody (mAb).	Tetradecanoylphorbol Acetate	258-261	thymus cell antigen 1, theta	Mus musculus	18-23
1506411-7	1992	Furthermore, these alterations could be markedly reduced by prolonged pretreatment with 12-O-tetradecanoylphorbol-13-acetate (R2 gene expression increased by only 1.3, 1.5 and 2.3-fold after 6, 12, and 24 hours of TGF-beta 1 treatment, respectively), suggesting a role for a protein kinase C pathway in the TGF-beta 1 regulated changes in ribonucleotide reductase gene expression.	Tetradecanoylphorbol Acetate	88-124	transforming growth factor beta 1	Homo sapiens	214-224
1324247-7	1992	Preincubation of the cells with 10 nM TPA for 5 minutes markedly inhibited the PTH-evoked [Ca2+]i increase.	Tetradecanoylphorbol Acetate	38-41	parathyroid hormone	Rattus norvegicus	79-82
1506411-7	1992	Furthermore, these alterations could be markedly reduced by prolonged pretreatment with 12-O-tetradecanoylphorbol-13-acetate (R2 gene expression increased by only 1.3, 1.5 and 2.3-fold after 6, 12, and 24 hours of TGF-beta 1 treatment, respectively), suggesting a role for a protein kinase C pathway in the TGF-beta 1 regulated changes in ribonucleotide reductase gene expression.	Tetradecanoylphorbol Acetate	88-124	transforming growth factor beta 1	Homo sapiens	307-317
1506412-9	1992	When the PKC activity was measured by the histone phosphorylation assay a substantial fraction of the initial enzyme activity could still be detected after 4 days of TPA treatment.	Tetradecanoylphorbol Acetate	166-169	proline rich transmembrane protein 2	Homo sapiens	9-12
1506412-0	1992	Protein kinase C remains functionally active during TPA induced neuronal differentiation of SH-SY5Y human neuroblastoma cells.	Tetradecanoylphorbol Acetate	52-55	proline rich transmembrane protein 2	Homo sapiens	0-16
1506412-10	1992	Taken together, the data demonstrate that PKC remains functionally active during TPA induced differentiation of SH-SY5Y cells, which may suggest a continuous role for the enzyme during the differentiation process.	Tetradecanoylphorbol Acetate	81-84	proline rich transmembrane protein 2	Homo sapiens	42-45
1506412-2	1992	In other cell systems, TPA treatment frequently leads to down-regulation of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	23-26	proline rich transmembrane protein 2	Homo sapiens	76-92
1506412-2	1992	In other cell systems, TPA treatment frequently leads to down-regulation of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	23-26	proline rich transmembrane protein 2	Homo sapiens	94-97
1506412-3	1992	However, we now report that TPA-treated and non-treated SH-SY5Y cells express PKC-alpha, but not PKC-beta and PKC-gamma, mRNA.	Tetradecanoylphorbol Acetate	28-31	protein kinase C alpha	Homo sapiens	78-87
1506412-4	1992	Furthermore, only a slight down-regulation of the PKC-alpha protein could be seen during prolonged treatment with 16 nM TPA, the concentration giving optimal differentiation.	Tetradecanoylphorbol Acetate	120-123	protein kinase C alpha	Homo sapiens	50-59
1506412-5	1992	In contrast, a higher concentration of TPA (1.6 microM) results in a poor neuronal differentiation and a complete down-regulation of PKC-alpha.	Tetradecanoylphorbol Acetate	39-42	protein kinase C alpha	Homo sapiens	133-142
1506412-6	1992	PKC-alpha was rapidly translocated to the particulate fraction and remained membrane bound for at least 4 days during treatment with 16 nM TPA.	Tetradecanoylphorbol Acetate	139-142	protein kinase C alpha	Homo sapiens	0-9
1333537-10	1992	However, prolonged treatment of cultures with PMA to desensitize PKC did not eliminate the Il-1 beta induction of NGF mRNA.	Tetradecanoylphorbol Acetate	46-49	proline rich transmembrane protein 2	Homo sapiens	65-68
1518836-2	1992	In the present studies, THP-1 human monocytic leukemia cells were used to investigate mechanisms responsible for expression of the AcLDL receptor gene after treatment with phorbol 12-myristate 13-acetate (TPA).	Tetradecanoylphorbol Acetate	172-203	GLI family zinc finger 2	Homo sapiens	24-29
1323817-5	1992	Transfection of the smg p21 cDNAs inhibited the activated ras p21-, PDGF- or TPA-stimulated c-fos-luciferase expression, but did not inhibit the activated c-raf-1 kinase- or Bt2cAMP-stimulated reaction.	Tetradecanoylphorbol Acetate	77-80	small nuclear ribonucleoprotein polypeptide G	Mus musculus	20-23
1386920-2	1992	We found that mutant Ras blocks serum- and 12-O-tetradecanoyl phorbol 13-acetate-induced activation of Raf-1 kinase in NIH3T3 cells and Raf-1 as well as B-Raf PSK stimulation by nerve growth factor (NGF) in PC12 pheochromocytoma cells.	Tetradecanoylphorbol Acetate	43-80	zinc fingers and homeoboxes 2	Mus musculus	103-106
1518836-2	1992	In the present studies, THP-1 human monocytic leukemia cells were used to investigate mechanisms responsible for expression of the AcLDL receptor gene after treatment with phorbol 12-myristate 13-acetate (TPA).	Tetradecanoylphorbol Acetate	205-208	GLI family zinc finger 2	Homo sapiens	24-29
1512228-6	1992	Bradykinin-induced formation of [3H]PEt in the [3H]glycerol-labeled cells was strictly dependent on extracellular Ca2+, whereas TPA-induced formation of [3H]PEt did not require extracellular Ca2+.	Tetradecanoylphorbol Acetate	128-131	kininogen 1	Canis lupus familiaris	0-10
1380156-9	1992	Cox-2 mRNA was preferentially induced by phorbol 12-myristate 13-acetate and lipopolysaccharide in human endothelial cells and monocytes.	Tetradecanoylphorbol Acetate	41-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
1379589-1	1992	While phorbal ester (PMA) activates only CFTR-dependent Cl- secretion and the Ca2+ ionophore A23187 only the Ca2+/calmodulin-dependent Cl- secretion, PMA and A23187 share the ability to down-regulate expression of the CFTR gene at the transcriptional level.	Tetradecanoylphorbol Acetate	21-24	CF transmembrane conductance regulator	Homo sapiens	41-45
1643643-1	1992	To investigate the role of protein kinase C (PKC) in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent growth of human melanocytes, we analyzed the effects of phorbol ester treatment on both PKC expression and growth control in these cells.	Tetradecanoylphorbol Acetate	57-93	protein kinase C alpha	Homo sapiens	45-48
1643643-1	1992	To investigate the role of protein kinase C (PKC) in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent growth of human melanocytes, we analyzed the effects of phorbol ester treatment on both PKC expression and growth control in these cells.	Tetradecanoylphorbol Acetate	95-98	protein kinase C alpha	Homo sapiens	45-48
1643643-4	1992	Dose-response studies revealed that the most effective TPA concentration for stimulation of DNA synthesis and growth of melanocytes (10 ng/ml TPA) also supported a relatively high level of PKC enzyme activity, increased membrane association of the PKC alpha and PKC epsilon isoforms, and led to a high level of phosphorylation of a major PKC substrate, the myristoylated alanine-rich C kinase substrate (MARCKS) protein.	Tetradecanoylphorbol Acetate	55-58	protein kinase C alpha	Homo sapiens	189-192
1643643-4	1992	Dose-response studies revealed that the most effective TPA concentration for stimulation of DNA synthesis and growth of melanocytes (10 ng/ml TPA) also supported a relatively high level of PKC enzyme activity, increased membrane association of the PKC alpha and PKC epsilon isoforms, and led to a high level of phosphorylation of a major PKC substrate, the myristoylated alanine-rich C kinase substrate (MARCKS) protein.	Tetradecanoylphorbol Acetate	55-58	protein kinase C alpha	Homo sapiens	248-257
1643643-4	1992	Dose-response studies revealed that the most effective TPA concentration for stimulation of DNA synthesis and growth of melanocytes (10 ng/ml TPA) also supported a relatively high level of PKC enzyme activity, increased membrane association of the PKC alpha and PKC epsilon isoforms, and led to a high level of phosphorylation of a major PKC substrate, the myristoylated alanine-rich C kinase substrate (MARCKS) protein.	Tetradecanoylphorbol Acetate	55-58	protein kinase C alpha	Homo sapiens	248-251
1322203-7	1992	We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2).	Tetradecanoylphorbol Acetate	88-119	interferon gamma	Homo sapiens	158-167
1643643-4	1992	Dose-response studies revealed that the most effective TPA concentration for stimulation of DNA synthesis and growth of melanocytes (10 ng/ml TPA) also supported a relatively high level of PKC enzyme activity, increased membrane association of the PKC alpha and PKC epsilon isoforms, and led to a high level of phosphorylation of a major PKC substrate, the myristoylated alanine-rich C kinase substrate (MARCKS) protein.	Tetradecanoylphorbol Acetate	142-145	protein kinase C alpha	Homo sapiens	189-192
1643643-4	1992	Dose-response studies revealed that the most effective TPA concentration for stimulation of DNA synthesis and growth of melanocytes (10 ng/ml TPA) also supported a relatively high level of PKC enzyme activity, increased membrane association of the PKC alpha and PKC epsilon isoforms, and led to a high level of phosphorylation of a major PKC substrate, the myristoylated alanine-rich C kinase substrate (MARCKS) protein.	Tetradecanoylphorbol Acetate	142-145	protein kinase C alpha	Homo sapiens	248-257
1643643-4	1992	Dose-response studies revealed that the most effective TPA concentration for stimulation of DNA synthesis and growth of melanocytes (10 ng/ml TPA) also supported a relatively high level of PKC enzyme activity, increased membrane association of the PKC alpha and PKC epsilon isoforms, and led to a high level of phosphorylation of a major PKC substrate, the myristoylated alanine-rich C kinase substrate (MARCKS) protein.	Tetradecanoylphorbol Acetate	142-145	protein kinase C alpha	Homo sapiens	248-251
1643643-6	1992	Furthermore, treatment of melanocytes with 100 ng/ml TPA for 48 h resulted in a marked decrease in total PKC enzyme activity and the loss of expression of the PKC alpha and PKC epsilon isoforms in both the cytosol and membrane-bound fractions, when examined by immunoblot analysis.	Tetradecanoylphorbol Acetate	53-56	protein kinase C alpha	Homo sapiens	105-108
1643643-6	1992	Furthermore, treatment of melanocytes with 100 ng/ml TPA for 48 h resulted in a marked decrease in total PKC enzyme activity and the loss of expression of the PKC alpha and PKC epsilon isoforms in both the cytosol and membrane-bound fractions, when examined by immunoblot analysis.	Tetradecanoylphorbol Acetate	53-56	protein kinase C alpha	Homo sapiens	159-168
1643643-7	1992	These results, taken together, suggest that continuous activation of PKC by TPA, rather than the loss of PKC due to TPA-induced down-regulation, is responsible for the growth-stimulatory effects of phorbol esters on normal human melanocytes.	Tetradecanoylphorbol Acetate	76-79	protein kinase C alpha	Homo sapiens	69-72
1643643-8	1992	Additionally, the conditioned medium from TPA-treated human melanocytes stimulated DNA synthesis in quiescent melanocytes and human melanoma cells, thus suggesting that activation of the PKC signaling pathway in melanocytes leads to the production of an autocrine growth factor.	Tetradecanoylphorbol Acetate	42-45	protein kinase C alpha	Homo sapiens	187-190
1386364-10	1992	Phorbol 12-myristate 13-acetate induced NF-kappa B with a similar time course to IL1 in 70Z/3 but only after 4 h in EL4.IL1 was unaffected by a protein kinase C inhibitor (staurosporine).	Tetradecanoylphorbol Acetate	0-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	40-50
1502168-5	1992	Here we demonstrate that p56lck slows the rate of phorbol 12-myristate 13-acetate-induced internalization of CD4 in a manner that depends on a physical association between p56lck and CD4.	Tetradecanoylphorbol Acetate	50-81	CD4 molecule	Homo sapiens	109-112
1502168-5	1992	Here we demonstrate that p56lck slows the rate of phorbol 12-myristate 13-acetate-induced internalization of CD4 in a manner that depends on a physical association between p56lck and CD4.	Tetradecanoylphorbol Acetate	50-81	CD4 molecule	Homo sapiens	183-186
1354412-4	1992	TPA treatment induced the coexpression of CD22 (mean 49%) and CD11c (mean 48%) and tartrate-resistant acid phosphatase in seven of eight cases.	Tetradecanoylphorbol Acetate	0-3	CD22 molecule	Homo sapiens	42-46
1514580-5	1992	Angiotensin II increased RNA content by 28% at 48 h but had no effect on growth up to 72 h. Growth stimulation and increased nuclear protein kinase C (PKC) activity were induced by contraction, NE, and PMA treatment and were inhibited by staurosporine (a PKC inhibitor), suggestive of a central role for PKC.	Tetradecanoylphorbol Acetate	202-205	angiotensinogen	Homo sapiens	0-14
1417911-5	1992	The effects of TPA on RPE cells cannot be explained by the activation of protein kinase C. An alternative possibility is that the effects of TPA on insulin-stimulated glucose disposal in RPE cells is mediated by a change in adenosine concentration and/or the affinity/number of its receptors.	Tetradecanoylphorbol Acetate	141-144	insulin	Homo sapiens	148-155
1417911-3	1992	TPA at low concentrations of insulin increases the rates of glucose transport and glucose oxidation.	Tetradecanoylphorbol Acetate	0-3	insulin	Homo sapiens	29-36
1322203-7	1992	We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2).	Tetradecanoylphorbol Acetate	88-119	interferon gamma	Homo sapiens	226-235
1322203-7	1992	We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2).	Tetradecanoylphorbol Acetate	88-119	interleukin 2	Homo sapiens	279-292
1322203-7	1992	We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2).	Tetradecanoylphorbol Acetate	88-119	interleukin 2	Homo sapiens	294-298
1322203-7	1992	We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2).	Tetradecanoylphorbol Acetate	121-124	interferon gamma	Homo sapiens	158-167
1322203-7	1992	We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2).	Tetradecanoylphorbol Acetate	121-124	interferon gamma	Homo sapiens	226-235
1322203-7	1992	We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2).	Tetradecanoylphorbol Acetate	121-124	interleukin 2	Homo sapiens	279-292
1322203-7	1992	We now report that PA682BM-1 can be triggered by the protein kinase C (PKC) activators, phorbol 12-myristate 13-acetate (PMA) and (-)Indolactam-v, to secrete IFN gamma, whereas JLP(c) cells spontaneously produce low levels of IFN gamma that can be enhanced by PKC activators and interleukin-2 (IL-2).	Tetradecanoylphorbol Acetate	121-124	interleukin 2	Homo sapiens	294-298
1322305-8	1992	Injection with IL-1, interferon-gamma, lipopolysaccharide, or phorbol 12-myristate 13-acetate also induced IL-6 in murine skin.	Tetradecanoylphorbol Acetate	62-93	interleukin 6	Mus musculus	107-111
1426703-1	1992	In neutrophils, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced the translocation of the Ca(++)- and phospholipid-dependent protein kinase, protein kinase C (PK-C) from the soluble to the particulate fraction.	Tetradecanoylphorbol Acetate	34-70	proline rich transmembrane protein 2	Homo sapiens	161-177
1426703-1	1992	In neutrophils, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced the translocation of the Ca(++)- and phospholipid-dependent protein kinase, protein kinase C (PK-C) from the soluble to the particulate fraction.	Tetradecanoylphorbol Acetate	34-70	proline rich transmembrane protein 2	Homo sapiens	179-183
1426703-1	1992	In neutrophils, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced the translocation of the Ca(++)- and phospholipid-dependent protein kinase, protein kinase C (PK-C) from the soluble to the particulate fraction.	Tetradecanoylphorbol Acetate	72-75	proline rich transmembrane protein 2	Homo sapiens	161-177
1426703-1	1992	In neutrophils, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced the translocation of the Ca(++)- and phospholipid-dependent protein kinase, protein kinase C (PK-C) from the soluble to the particulate fraction.	Tetradecanoylphorbol Acetate	72-75	proline rich transmembrane protein 2	Homo sapiens	179-183
1426703-4	1992	Bone marrow and undifferentiated HL-60 cells also translocated PK-C to the particulate fraction in response to TPA but did not accumulate the soluble Ca(++)- and phospholipid-independent form of the enzyme.	Tetradecanoylphorbol Acetate	111-114	proline rich transmembrane protein 2	Homo sapiens	63-67
1322286-13	1992	When the cells were pretreated with a high concentration of PMA (1 microM/24 h) to down-regulate PKC, the TNF alpha dose-dependent increase in [3H]thymidine incorporation and decrease in DNA content were only slightly inhibited, suggesting that the main effects of TNF alpha are independent of PKC.	Tetradecanoylphorbol Acetate	60-63	tumor necrosis factor	Rattus norvegicus	106-115
1398754-7	1992	OX42 treatment of rat PMNL inhibited phorbol myristate acetate (PMA) activated adhesion by 88%, while TA3 only inhibited this adhesion in combination with OX42, resulting in 99% inhibition of PMA-induced PMNL adhesion.	Tetradecanoylphorbol Acetate	192-195	trace amine-associated receptor 9	Rattus norvegicus	102-105
1322286-13	1992	When the cells were pretreated with a high concentration of PMA (1 microM/24 h) to down-regulate PKC, the TNF alpha dose-dependent increase in [3H]thymidine incorporation and decrease in DNA content were only slightly inhibited, suggesting that the main effects of TNF alpha are independent of PKC.	Tetradecanoylphorbol Acetate	60-63	tumor necrosis factor	Rattus norvegicus	265-274
1446649-3	1992	The release of IR-ET-1 from control cells (no TPA) increased according to time for up to 72 h. In the presence of TPA, the release of IR-ET-1 from the cells was higher than the control level for up to 8 h, but was lower thereafter and reached a plateau after 48 h. TPA dose-dependently stimulated IR-ET-1 release during incubation for 4 h, but suppressed it after incubation for 72 h. Stimulation of PKC by diacylglycerol mimicked the early (4 h) action of TPA.	Tetradecanoylphorbol Acetate	46-49	endothelin 1	Homo sapiens	18-22
1446649-3	1992	The release of IR-ET-1 from control cells (no TPA) increased according to time for up to 72 h. In the presence of TPA, the release of IR-ET-1 from the cells was higher than the control level for up to 8 h, but was lower thereafter and reached a plateau after 48 h. TPA dose-dependently stimulated IR-ET-1 release during incubation for 4 h, but suppressed it after incubation for 72 h. Stimulation of PKC by diacylglycerol mimicked the early (4 h) action of TPA.	Tetradecanoylphorbol Acetate	114-117	endothelin 1	Homo sapiens	18-22
1446649-3	1992	The release of IR-ET-1 from control cells (no TPA) increased according to time for up to 72 h. In the presence of TPA, the release of IR-ET-1 from the cells was higher than the control level for up to 8 h, but was lower thereafter and reached a plateau after 48 h. TPA dose-dependently stimulated IR-ET-1 release during incubation for 4 h, but suppressed it after incubation for 72 h. Stimulation of PKC by diacylglycerol mimicked the early (4 h) action of TPA.	Tetradecanoylphorbol Acetate	114-117	endothelin 1	Homo sapiens	137-141
1446649-3	1992	The release of IR-ET-1 from control cells (no TPA) increased according to time for up to 72 h. In the presence of TPA, the release of IR-ET-1 from the cells was higher than the control level for up to 8 h, but was lower thereafter and reached a plateau after 48 h. TPA dose-dependently stimulated IR-ET-1 release during incubation for 4 h, but suppressed it after incubation for 72 h. Stimulation of PKC by diacylglycerol mimicked the early (4 h) action of TPA.	Tetradecanoylphorbol Acetate	114-117	endothelin 1	Homo sapiens	137-141
1446649-3	1992	The release of IR-ET-1 from control cells (no TPA) increased according to time for up to 72 h. In the presence of TPA, the release of IR-ET-1 from the cells was higher than the control level for up to 8 h, but was lower thereafter and reached a plateau after 48 h. TPA dose-dependently stimulated IR-ET-1 release during incubation for 4 h, but suppressed it after incubation for 72 h. Stimulation of PKC by diacylglycerol mimicked the early (4 h) action of TPA.	Tetradecanoylphorbol Acetate	114-117	endothelin 1	Homo sapiens	18-22
1446649-3	1992	The release of IR-ET-1 from control cells (no TPA) increased according to time for up to 72 h. In the presence of TPA, the release of IR-ET-1 from the cells was higher than the control level for up to 8 h, but was lower thereafter and reached a plateau after 48 h. TPA dose-dependently stimulated IR-ET-1 release during incubation for 4 h, but suppressed it after incubation for 72 h. Stimulation of PKC by diacylglycerol mimicked the early (4 h) action of TPA.	Tetradecanoylphorbol Acetate	114-117	endothelin 1	Homo sapiens	137-141
1446649-3	1992	The release of IR-ET-1 from control cells (no TPA) increased according to time for up to 72 h. In the presence of TPA, the release of IR-ET-1 from the cells was higher than the control level for up to 8 h, but was lower thereafter and reached a plateau after 48 h. TPA dose-dependently stimulated IR-ET-1 release during incubation for 4 h, but suppressed it after incubation for 72 h. Stimulation of PKC by diacylglycerol mimicked the early (4 h) action of TPA.	Tetradecanoylphorbol Acetate	114-117	endothelin 1	Homo sapiens	137-141
1446649-3	1992	The release of IR-ET-1 from control cells (no TPA) increased according to time for up to 72 h. In the presence of TPA, the release of IR-ET-1 from the cells was higher than the control level for up to 8 h, but was lower thereafter and reached a plateau after 48 h. TPA dose-dependently stimulated IR-ET-1 release during incubation for 4 h, but suppressed it after incubation for 72 h. Stimulation of PKC by diacylglycerol mimicked the early (4 h) action of TPA.	Tetradecanoylphorbol Acetate	114-117	endothelin 1	Homo sapiens	18-22
1446649-3	1992	The release of IR-ET-1 from control cells (no TPA) increased according to time for up to 72 h. In the presence of TPA, the release of IR-ET-1 from the cells was higher than the control level for up to 8 h, but was lower thereafter and reached a plateau after 48 h. TPA dose-dependently stimulated IR-ET-1 release during incubation for 4 h, but suppressed it after incubation for 72 h. Stimulation of PKC by diacylglycerol mimicked the early (4 h) action of TPA.	Tetradecanoylphorbol Acetate	114-117	endothelin 1	Homo sapiens	137-141
1446649-3	1992	The release of IR-ET-1 from control cells (no TPA) increased according to time for up to 72 h. In the presence of TPA, the release of IR-ET-1 from the cells was higher than the control level for up to 8 h, but was lower thereafter and reached a plateau after 48 h. TPA dose-dependently stimulated IR-ET-1 release during incubation for 4 h, but suppressed it after incubation for 72 h. Stimulation of PKC by diacylglycerol mimicked the early (4 h) action of TPA.	Tetradecanoylphorbol Acetate	114-117	endothelin 1	Homo sapiens	137-141
1446649-4	1992	On the other hand, pretreatment of cells with TPA to downregulate PKC significantly suppressed basal and thrombin- or FCS-stimulated IR-ET-1 release.	Tetradecanoylphorbol Acetate	46-49	coagulation factor II, thrombin	Homo sapiens	105-113
1446649-4	1992	On the other hand, pretreatment of cells with TPA to downregulate PKC significantly suppressed basal and thrombin- or FCS-stimulated IR-ET-1 release.	Tetradecanoylphorbol Acetate	46-49	endothelin 1	Homo sapiens	136-140
1639858-6	1992	Involucrin was induced about ninefold by both TPA and calcium as early as 8 hours after stimulation, suggesting transcriptional regulation of this gene during differentiation.	Tetradecanoylphorbol Acetate	46-49	involucrin	Homo sapiens	0-10
1379255-6	1992	Preincubation with PMA abolished the inhibitory effect of insulin, while preincubation with insulin did not inhibit PMA stimulation.	Tetradecanoylphorbol Acetate	19-22	insulin	Homo sapiens	58-65
1639859-5	1992	In contrast to PKC-alpha, the membrane localization of PKC-delta, -epsilon, and -zeta was not enhanced by extraction in Ca(2+)-containing buffers, whereas acute TPA treatment increased membrane association of PKC-alpha, -delta, and -epsilon but not that of PKC-zeta.	Tetradecanoylphorbol Acetate	161-164	protein kinase C, alpha	Mus musculus	209-240
1639861-2	1992	We demonstrated that the protein kinase C (PKC) activator 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) in concert with Ca++ ionophore A23187 induced expression of TNF-alpha mRNA and protein, whereas an inactive PMA analogue (alpha PMA) had no effect.	Tetradecanoylphorbol Acetate	109-112	tumor necrosis factor	Homo sapiens	174-183
1330001-9	1992	This impairment seems not to be mediated by transformation-induced inactivation of the protein kinase C pathway since phorbol 12-myristate 13-acetate (PMA) induced IL-6 production equally well in all C127 cell-derived clones.	Tetradecanoylphorbol Acetate	118-149	interleukin 6	Mus musculus	164-168
1330001-9	1992	This impairment seems not to be mediated by transformation-induced inactivation of the protein kinase C pathway since phorbol 12-myristate 13-acetate (PMA) induced IL-6 production equally well in all C127 cell-derived clones.	Tetradecanoylphorbol Acetate	151-154	interleukin 6	Mus musculus	164-168
1641975-5	1992	UV-crosslinking analysis of NF-kappa B-specific proteins induced in TPA-treated cells showed the presence of 45 and 55 kDa NF-kappa B-binding protein in TPA-induced HNHIVdt4 cells while, in HNHIV alpha 1 cells, we detected only 55-, 110-, and 200-kDa proteins, but no 45-kDa protein.	Tetradecanoylphorbol Acetate	68-71	nuclear factor kappa B subunit 1	Homo sapiens	28-38
1380176-2	1992	Phorbol myristate acetate, which is known to activate PKC, was able to mimic TNF alpha-induced up-regulation of ICAM-1 and partly also VCAM-1 expression.	Tetradecanoylphorbol Acetate	0-25	tumor necrosis factor	Homo sapiens	77-86
1380176-2	1992	Phorbol myristate acetate, which is known to activate PKC, was able to mimic TNF alpha-induced up-regulation of ICAM-1 and partly also VCAM-1 expression.	Tetradecanoylphorbol Acetate	0-25	vascular cell adhesion molecule 1	Homo sapiens	135-141
1496542-3	1992	PHA alone or in combination with PMA was the most effective stimulant in up-regulating IL-6 binding in all the experiments performed.	Tetradecanoylphorbol Acetate	33-36	interleukin 6	Homo sapiens	87-91
1324464-7	1992	RSV also appeared to prime eosinophils to the effects of other known cell activators, as demonstrated by an increase in superoxide production upon subsequent stimulation of RSV-primed cells with phorbol-12-myristate-13-acetate (21.4 +/- 5.8 versus 9.4 +/- 2.7 nmol cytochrome c reduction/5 x 10(5) cells for primed and unprimed cells, respectively) (p less than 0.04).	Tetradecanoylphorbol Acetate	195-226	cytochrome c, somatic	Homo sapiens	265-277
1496542-6	1992	The overall effect of the three pharmacological agents on mitogen-up-regulated IL-6 binding was minimal; most significant were a down-regulation by all three agents of IL-6 binding by small lymphocytes in PHA/PMA cultures, a down-regulation of IL-6 binding by CsA in PHA/PMA-induced large PBMC, and an up-regulation by verapamil of PMA-induced IL-6 binding in large PBMC.	Tetradecanoylphorbol Acetate	209-212	interleukin 6	Homo sapiens	168-172
1496542-6	1992	The overall effect of the three pharmacological agents on mitogen-up-regulated IL-6 binding was minimal; most significant were a down-regulation by all three agents of IL-6 binding by small lymphocytes in PHA/PMA cultures, a down-regulation of IL-6 binding by CsA in PHA/PMA-induced large PBMC, and an up-regulation by verapamil of PMA-induced IL-6 binding in large PBMC.	Tetradecanoylphorbol Acetate	209-212	interleukin 6	Homo sapiens	168-172
1496542-6	1992	The overall effect of the three pharmacological agents on mitogen-up-regulated IL-6 binding was minimal; most significant were a down-regulation by all three agents of IL-6 binding by small lymphocytes in PHA/PMA cultures, a down-regulation of IL-6 binding by CsA in PHA/PMA-induced large PBMC, and an up-regulation by verapamil of PMA-induced IL-6 binding in large PBMC.	Tetradecanoylphorbol Acetate	209-212	interleukin 6	Homo sapiens	168-172
1641975-5	1992	UV-crosslinking analysis of NF-kappa B-specific proteins induced in TPA-treated cells showed the presence of 45 and 55 kDa NF-kappa B-binding protein in TPA-induced HNHIVdt4 cells while, in HNHIV alpha 1 cells, we detected only 55-, 110-, and 200-kDa proteins, but no 45-kDa protein.	Tetradecanoylphorbol Acetate	153-156	nuclear factor kappa B subunit 1	Homo sapiens	28-38
1634545-0	1992	Interaction of AP-1-, AP-2-, and Sp1-like proteins with two distinct sites in the upstream regulatory region of the plasminogen activator inhibitor-1 gene mediates the phorbol 12-myristate 13-acetate response.	Tetradecanoylphorbol Acetate	168-199	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-19
1497665-4	1992	Human macrophages were viable and metabolically active as indicated by the MTT assay, and their respiratory burst response to phorbol myristate acetate was increased following incubation with Interferon-gamma, as expected for typical macrophages.	Tetradecanoylphorbol Acetate	126-151	interferon gamma	Homo sapiens	192-208
1322137-15	1992	The phorbol ester phorbol 12-myristate 13-acetate (PMA) also increased insulin promoter-driven CAT expression in the presence of 1 mM-, but not 11 mM-glucose.	Tetradecanoylphorbol Acetate	18-49	insulin	Homo sapiens	71-78
1633871-1	1992	The effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on the mRNA levels of two enzymes, thromboxane synthase (TXS) and prostaglandin endoperoxide synthase (PES), responsible for the synthesis of thromboxane A2 from arachidonic acid, were studied in human erythroleukemia (HEL) cells by RNA blot analysis.	Tetradecanoylphorbol Acetate	54-57	thromboxane A synthase 1	Homo sapiens	94-114
1633871-1	1992	The effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on the mRNA levels of two enzymes, thromboxane synthase (TXS) and prostaglandin endoperoxide synthase (PES), responsible for the synthesis of thromboxane A2 from arachidonic acid, were studied in human erythroleukemia (HEL) cells by RNA blot analysis.	Tetradecanoylphorbol Acetate	54-57	thromboxane A synthase 1	Homo sapiens	116-119
1633871-2	1992	TPA induced both TXS and PES mRNAs in HEL cells in a dose-dependent manner at 36 h. The half-maximal and maximal effects for the induction of both mRNAs were at approximately 3 x 10(-9) M and at 10(-8) M, respectively.	Tetradecanoylphorbol Acetate	0-3	thromboxane A synthase 1	Homo sapiens	17-20
1633871-3	1992	TXS and PES mRNA levels increased in a time-dependent fashion by TPA, and reached to 7- and 3.5-fold of the control, respectively after 48 h of TPA treatment.	Tetradecanoylphorbol Acetate	65-68	thromboxane A synthase 1	Homo sapiens	0-3
1633871-3	1992	TXS and PES mRNA levels increased in a time-dependent fashion by TPA, and reached to 7- and 3.5-fold of the control, respectively after 48 h of TPA treatment.	Tetradecanoylphorbol Acetate	144-147	thromboxane A synthase 1	Homo sapiens	0-3
1633871-4	1992	These results suggest that expression of TXS and PES genes in HEL cells were simultaneously stimulated by TPA.	Tetradecanoylphorbol Acetate	106-109	thromboxane A synthase 1	Homo sapiens	41-44
1633871-1	1992	The effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on the mRNA levels of two enzymes, thromboxane synthase (TXS) and prostaglandin endoperoxide synthase (PES), responsible for the synthesis of thromboxane A2 from arachidonic acid, were studied in human erythroleukemia (HEL) cells by RNA blot analysis.	Tetradecanoylphorbol Acetate	15-52	thromboxane A synthase 1	Homo sapiens	94-114
1633871-1	1992	The effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on the mRNA levels of two enzymes, thromboxane synthase (TXS) and prostaglandin endoperoxide synthase (PES), responsible for the synthesis of thromboxane A2 from arachidonic acid, were studied in human erythroleukemia (HEL) cells by RNA blot analysis.	Tetradecanoylphorbol Acetate	15-52	thromboxane A synthase 1	Homo sapiens	116-119
1322137-15	1992	The phorbol ester phorbol 12-myristate 13-acetate (PMA) also increased insulin promoter-driven CAT expression in the presence of 1 mM-, but not 11 mM-glucose.	Tetradecanoylphorbol Acetate	51-54	insulin	Homo sapiens	71-78
1637359-4	1992	The carbachol-, PDB- and 8-Br-cAMP-induced ISC responses were inhibited by pretreatment of the cells with PMA (0.5 microM) for 2 h, a time period in which PKC alpha, beta 1 and gamma levels were not changed.	Tetradecanoylphorbol Acetate	106-109	protein kinase C alpha	Homo sapiens	155-164
1632788-4	1992	Treatment of whole cells with 12-O-tetradecanoyl phorbol-13-acetate decreases the subsequent tyrosine phosphorylation of p115 in immune-complex kinase assays.	Tetradecanoylphorbol Acetate	30-67	USO1 vesicle transport factor	Homo sapiens	121-125
1637359-4	1992	The carbachol-, PDB- and 8-Br-cAMP-induced ISC responses were inhibited by pretreatment of the cells with PMA (0.5 microM) for 2 h, a time period in which PKC alpha, beta 1 and gamma levels were not changed.	Tetradecanoylphorbol Acetate	106-109	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	166-182
1636673-2	1992	Direct PKC activation with phorbol 12-myristate 13-acetate (PMA) stimulated transepithelial Cl- transport (measured as the short-circuit current), demonstrating that PKC could interact with the secretory apparatus.	Tetradecanoylphorbol Acetate	27-58	proline rich transmembrane protein 2	Homo sapiens	7-10
1636673-10	1992	These observations demonstrate that PKC does not participate in the secretory action of carbachol in T84 cells and suggest that direct PKC activation with DMIs and PMA stimulates an apical pool of PKC that is not accessible to carbachol applied to the basolateral membrane.	Tetradecanoylphorbol Acetate	164-167	proline rich transmembrane protein 2	Homo sapiens	135-138
1636673-2	1992	Direct PKC activation with phorbol 12-myristate 13-acetate (PMA) stimulated transepithelial Cl- transport (measured as the short-circuit current), demonstrating that PKC could interact with the secretory apparatus.	Tetradecanoylphorbol Acetate	27-58	proline rich transmembrane protein 2	Homo sapiens	166-169
1636673-10	1992	These observations demonstrate that PKC does not participate in the secretory action of carbachol in T84 cells and suggest that direct PKC activation with DMIs and PMA stimulates an apical pool of PKC that is not accessible to carbachol applied to the basolateral membrane.	Tetradecanoylphorbol Acetate	164-167	proline rich transmembrane protein 2	Homo sapiens	135-138
1636673-2	1992	Direct PKC activation with phorbol 12-myristate 13-acetate (PMA) stimulated transepithelial Cl- transport (measured as the short-circuit current), demonstrating that PKC could interact with the secretory apparatus.	Tetradecanoylphorbol Acetate	60-63	proline rich transmembrane protein 2	Homo sapiens	7-10
1636737-7	1992	Phorbol 12-myristate 13-acetate was also found to activate S6 kinase, and 24 h of pretreatment to deplete protein kinase C inhibited subsequent S6 kinase activation by a high concentration (10(-6) M) of angiotensin II.	Tetradecanoylphorbol Acetate	0-31	angiotensinogen	Homo sapiens	203-217
1636673-2	1992	Direct PKC activation with phorbol 12-myristate 13-acetate (PMA) stimulated transepithelial Cl- transport (measured as the short-circuit current), demonstrating that PKC could interact with the secretory apparatus.	Tetradecanoylphorbol Acetate	60-63	proline rich transmembrane protein 2	Homo sapiens	166-169
1377987-5	1992	In addition, the pyruvate kinase C (PKC) pathway does not seem to participate in the process either because in our system activation of PKC by 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) is insufficient by itself to induce HLA-DR. We found, however, that a second messenger pathway can be mediated by a G protein system since IL-4 concomitantly induces class II and p21ras expression which can be successfully blocked by a highly specific anti-p21ras monoclonal antibody.	Tetradecanoylphorbol Acetate	194-197	interleukin 4	Homo sapiens	338-342
1636729-7	1992	In addition to the generation of metabolites indicative of phospholipase C and/or D activity, [3H]lyso-PC, a product of phospholipase A2, was also generated in response to TPA.	Tetradecanoylphorbol Acetate	172-175	phospholipase A2 group IB	Homo sapiens	120-136
1611082-8	1992	Interleukin-1 (IL-1) and the phorbol ester phorbol myristate acetate, which mimic many effects of TNF-alpha on endothelial cells, have no effect on endothelial or human erytholeukemia (HEL)-cell GpIb alpha mRNA.	Tetradecanoylphorbol Acetate	43-68	tumor necrosis factor	Homo sapiens	98-107
1499042-3	1992	Secondly, bFGF and PMA induced a stimulated phospholipase A2 (PLA2)-catalyzed release of 14C arachidonate.	Tetradecanoylphorbol Acetate	19-22	phospholipase A2 group IB	Homo sapiens	44-60
1499042-3	1992	Secondly, bFGF and PMA induced a stimulated phospholipase A2 (PLA2)-catalyzed release of 14C arachidonate.	Tetradecanoylphorbol Acetate	19-22	phospholipase A2 group IB	Homo sapiens	62-66
1612026-7	1992	The protein kinase-C (PKC) activator phorbol 12-myristate 13-acetate increased [3H]thymidine incorporation, and TGF beta inhibited this action of phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	146-177	transforming growth factor, beta 1	Rattus norvegicus	112-120
1638676-4	1992	There was a TPA-independent, irreversible decrease in total PKC activity (70%) in the early emergence papillomas compared to that in the epidermis.	Tetradecanoylphorbol Acetate	12-15	protein kinase C, alpha	Mus musculus	60-63
1638676-5	1992	Immunoblot analysis of epidermis and papillomas taken 4 weeks following the cessation of TPA treatment, a time when PKC catalytic activity has completely recovered to control level in epidermis but not in papillomas, revealed that the levels of PKC-alpha and PKC-beta 2 were dramatically decreased in the cytosol of the papillomas, while the levels of these two isozymes in the particulate fraction were approximately equal to the epidermis.	Tetradecanoylphorbol Acetate	89-92	protein kinase C, alpha	Mus musculus	116-119
1638676-11	1992	These data demonstrate an irreversible decrease in and alteration of the subcellular distribution of PKC-alpha and beta 2 in DMBA-initiated/TPA-promoted papillomas.	Tetradecanoylphorbol Acetate	140-143	protein kinase C, alpha	Mus musculus	101-110
1628655-0	1992	Transcriptional activation of human (2"-5")oligoadenylate synthetase gene expression by the phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate in type-I-interferon-treated HL-60 and HeLa cells.	Tetradecanoylphorbol Acetate	106-143	interferon alpha 1	Homo sapiens	154-164
1421015-8	1992	Recombinant IL-1 beta induced a very low level of TNF alpha production in PMA-treated cells.	Tetradecanoylphorbol Acetate	74-77	interleukin 1 beta	Homo sapiens	12-21
1421015-8	1992	Recombinant IL-1 beta induced a very low level of TNF alpha production in PMA-treated cells.	Tetradecanoylphorbol Acetate	74-77	tumor necrosis factor	Homo sapiens	50-59
1645030-5	1992	Upon induction with 12-phorbol 13-myristate acetate (PMA), they secreted greater amounts of TGF-beta (500-1250 pg/ml), most of which was still inactive in a bioassay.	Tetradecanoylphorbol Acetate	53-56	transforming growth factor beta 1	Homo sapiens	92-100
1498085-5	1992	Phorbol myristate acetate enhanced its expression in DND39 cells as well as in the purified B cells in combination with IL-4.	Tetradecanoylphorbol Acetate	0-25	interleukin 4	Homo sapiens	120-124
1388136-3	1992	TPA-induced T-cell proliferation, expression of interleukin-2 receptor-alpha subunit (IL-2R alpha) and transferrin receptor, CD3 down-regulation and, lastly, the cytosol-to-membrane PKC translocation (determined by an enzymatic assay or by immunoblotting with a cross-reactive anti-PKC peptide antibody) were all facilitated by ionomycin.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	182-185
1388136-3	1992	TPA-induced T-cell proliferation, expression of interleukin-2 receptor-alpha subunit (IL-2R alpha) and transferrin receptor, CD3 down-regulation and, lastly, the cytosol-to-membrane PKC translocation (determined by an enzymatic assay or by immunoblotting with a cross-reactive anti-PKC peptide antibody) were all facilitated by ionomycin.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	282-285
1388136-4	1992	Immunoblots with isoenzyme-specific anti-PKC monoclonal antibodies demonstrated expression of immunoreactive PKC alpha, PKC beta and PKC gamma proteins that were translocated to the membrane upon TPA plus ionomycin stimulation.	Tetradecanoylphorbol Acetate	196-199	protein kinase C alpha	Homo sapiens	41-44
1388136-4	1992	Immunoblots with isoenzyme-specific anti-PKC monoclonal antibodies demonstrated expression of immunoreactive PKC alpha, PKC beta and PKC gamma proteins that were translocated to the membrane upon TPA plus ionomycin stimulation.	Tetradecanoylphorbol Acetate	196-199	protein kinase C alpha	Homo sapiens	109-118
1388136-7	1992	Ionomycin synergized with TPA in increasing the expression of PKC alpha and PKC beta mRNA.	Tetradecanoylphorbol Acetate	26-29	protein kinase C alpha	Homo sapiens	62-71
1388136-11	1992	Moreover, the combined effects of TPA and ionomycin on T-cell function and cell-surface antigen expression appear to be due, at least in part, to their synergistic activation of distinct PKC isoenzyme(s).	Tetradecanoylphorbol Acetate	34-37	protein kinase C alpha	Homo sapiens	187-190
1319472-3	1992	The expression of growth-associated protein-43 (GAP-43) mRNA was also observed by a combined application of TPA and diBu-cAMP.	Tetradecanoylphorbol Acetate	108-111	growth associated protein 43	Mus musculus	18-46
1512301-6	1992	After stimulation with calcium ionophore A23187 and phorbol myristic acetate (PMA), the production of IL-4 was markedly increased in both patients and normals.	Tetradecanoylphorbol Acetate	78-81	interleukin 4	Homo sapiens	102-106
1535370-12	1992	Moreover, in cells responding to phorbol myristate acetate, a compound that triggers activation of phospholipase D, TNF-alpha synthesis was also inhibited by propranolol.	Tetradecanoylphorbol Acetate	33-58	tumor necrosis factor	Homo sapiens	116-125
1319472-3	1992	The expression of growth-associated protein-43 (GAP-43) mRNA was also observed by a combined application of TPA and diBu-cAMP.	Tetradecanoylphorbol Acetate	108-111	growth associated protein 43	Mus musculus	48-54
1517149-5	1992	These findings overall suggest that the serine protease inhibitor, TAPP-Br, might inhibit the cell growth of colon carcinoma cell lines through suppressing the expression of genes whose promoter contains a 12-O-tetradecanoylphorbol-13-acetate-responsive element or serum-responsive element.	Tetradecanoylphorbol Acetate	206-242	coagulation factor II, thrombin	Homo sapiens	40-55
1387724-12	1992	In conclusion, PIC and FDP.D dimer are useful indices not only to detect the activated state of the fibrinolytic system but also to know clot lysis in tPA treatment.	Tetradecanoylphorbol Acetate	151-154	otoraplin	Homo sapiens	23-26
1318407-9	1992	(iv) H13 gene expression decreases upon terminal differentiation of the human promyelocytic leukemia cell line HL-60 into granulocytes or macrophages by dimethyl sulfoxide or PMA, respectively.	Tetradecanoylphorbol Acetate	175-178	H1.3 linker histone, cluster member	Homo sapiens	5-8
1493432-1	1992	Previous studies showed that the human monocytic leukemia cell line THP-1 can be induced to undergo monocytic differentiation by tumor promoting phorbol esters (TPA), suggesting that protein kinase C (PK-C), the primary binding site of TPA, may play a role in the control of monocytic differentiation: The effect of exogenous phospholipase C (PLC) on THP-1 cells was investigated.	Tetradecanoylphorbol Acetate	161-164	GLI family zinc finger 2	Homo sapiens	68-73
1355050-3	1992	TPA induced an increase in VP mRNA size and stimulated 1.9-fold the secretion of VP without an increase in VP mRNA content.	Tetradecanoylphorbol Acetate	0-3	arginine vasopressin	Rattus norvegicus	27-29
1493432-1	1992	Previous studies showed that the human monocytic leukemia cell line THP-1 can be induced to undergo monocytic differentiation by tumor promoting phorbol esters (TPA), suggesting that protein kinase C (PK-C), the primary binding site of TPA, may play a role in the control of monocytic differentiation: The effect of exogenous phospholipase C (PLC) on THP-1 cells was investigated.	Tetradecanoylphorbol Acetate	161-164	proline rich transmembrane protein 2	Homo sapiens	201-205
1493432-1	1992	Previous studies showed that the human monocytic leukemia cell line THP-1 can be induced to undergo monocytic differentiation by tumor promoting phorbol esters (TPA), suggesting that protein kinase C (PK-C), the primary binding site of TPA, may play a role in the control of monocytic differentiation: The effect of exogenous phospholipase C (PLC) on THP-1 cells was investigated.	Tetradecanoylphorbol Acetate	161-164	GLI family zinc finger 2	Homo sapiens	351-356
1493432-1	1992	Previous studies showed that the human monocytic leukemia cell line THP-1 can be induced to undergo monocytic differentiation by tumor promoting phorbol esters (TPA), suggesting that protein kinase C (PK-C), the primary binding site of TPA, may play a role in the control of monocytic differentiation: The effect of exogenous phospholipase C (PLC) on THP-1 cells was investigated.	Tetradecanoylphorbol Acetate	236-239	GLI family zinc finger 2	Homo sapiens	68-73
1493432-1	1992	Previous studies showed that the human monocytic leukemia cell line THP-1 can be induced to undergo monocytic differentiation by tumor promoting phorbol esters (TPA), suggesting that protein kinase C (PK-C), the primary binding site of TPA, may play a role in the control of monocytic differentiation: The effect of exogenous phospholipase C (PLC) on THP-1 cells was investigated.	Tetradecanoylphorbol Acetate	236-239	proline rich transmembrane protein 2	Homo sapiens	183-199
1493432-1	1992	Previous studies showed that the human monocytic leukemia cell line THP-1 can be induced to undergo monocytic differentiation by tumor promoting phorbol esters (TPA), suggesting that protein kinase C (PK-C), the primary binding site of TPA, may play a role in the control of monocytic differentiation: The effect of exogenous phospholipase C (PLC) on THP-1 cells was investigated.	Tetradecanoylphorbol Acetate	236-239	proline rich transmembrane protein 2	Homo sapiens	201-205
1355050-3	1992	TPA induced an increase in VP mRNA size and stimulated 1.9-fold the secretion of VP without an increase in VP mRNA content.	Tetradecanoylphorbol Acetate	0-3	arginine vasopressin	Rattus norvegicus	81-83
1355050-3	1992	TPA induced an increase in VP mRNA size and stimulated 1.9-fold the secretion of VP without an increase in VP mRNA content.	Tetradecanoylphorbol Acetate	0-3	arginine vasopressin	Rattus norvegicus	81-83
1322550-3	1992	This effect of TPA on LTB4 receptor binding was found to be due to the activation of PKC as membrane treated with purified PKC (type III) produced the same effect.	Tetradecanoylphorbol Acetate	15-18	proline rich transmembrane protein 2	Homo sapiens	85-88
1322550-3	1992	This effect of TPA on LTB4 receptor binding was found to be due to the activation of PKC as membrane treated with purified PKC (type III) produced the same effect.	Tetradecanoylphorbol Acetate	15-18	proline rich transmembrane protein 2	Homo sapiens	123-126
1320411-3	1992	Within 5 min of treatment of human cervical carcinoma A431 cells with EGF or phorbol myristate acetate (PMA), a greater than 3-fold activation of p42mapk was measured.	Tetradecanoylphorbol Acetate	77-102	mitogen-activated protein kinase 1	Homo sapiens	146-153
1508958-5	1992	PMA-induced differentiation and nitroblue tetrazolium reduction by PMA-treated cells was only partially inhibited (about 20-30%) by indomethacin and nordihydroguiaretic acid (cyclooxygenase and lipoxygenase inhibitors respectively), but not by superoxide dismutase, catalase or mannitol.	Tetradecanoylphorbol Acetate	0-3	catalase	Homo sapiens	266-274
1508958-5	1992	PMA-induced differentiation and nitroblue tetrazolium reduction by PMA-treated cells was only partially inhibited (about 20-30%) by indomethacin and nordihydroguiaretic acid (cyclooxygenase and lipoxygenase inhibitors respectively), but not by superoxide dismutase, catalase or mannitol.	Tetradecanoylphorbol Acetate	67-70	catalase	Homo sapiens	266-274
1320411-3	1992	Within 5 min of treatment of human cervical carcinoma A431 cells with EGF or phorbol myristate acetate (PMA), a greater than 3-fold activation of p42mapk was measured.	Tetradecanoylphorbol Acetate	104-107	mitogen-activated protein kinase 1	Homo sapiens	146-153
1322178-9	1992	The present results indicate that OAG and PMA also modulate the A23187-stimulated [3H]arachidonate mobilization so as to render it less sensitive to inhibitors of phospholipase A2.	Tetradecanoylphorbol Acetate	42-45	phospholipase A2 group IB	Homo sapiens	163-179
1380299-4	1992	The activity of PKC was stimulated by phorbol 12-myristate 13-acetate (PMA) and was inhibited with calphostin C.	Tetradecanoylphorbol Acetate	38-69	proline rich transmembrane protein 2	Homo sapiens	16-19
1377951-3	1992	We concluded that sphingosine is a potent inhibitor of FN release from the cell surface, independent of its inhibition of PKC; and that TPA stimulates release of FN by a pathway other than activation of PKC.	Tetradecanoylphorbol Acetate	136-139	fibronectin 1	Homo sapiens	162-164
1377951-4	1992	We found that the activation of PKC by TPA was accompanied by inhibition of the cAMP-dependent protein kinase (PKA).	Tetradecanoylphorbol Acetate	39-42	proline rich transmembrane protein 2	Homo sapiens	32-35
1377951-1	1992	In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA.	Tetradecanoylphorbol Acetate	85-121	fibronectin 1	Homo sapiens	65-76
1377951-1	1992	In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA.	Tetradecanoylphorbol Acetate	85-121	fibronectin 1	Homo sapiens	78-80
1377951-1	1992	In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA.	Tetradecanoylphorbol Acetate	85-121	proline rich transmembrane protein 2	Homo sapiens	198-214
1377951-1	1992	In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA.	Tetradecanoylphorbol Acetate	85-121	proline rich transmembrane protein 2	Homo sapiens	216-219
1377951-1	1992	In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA.	Tetradecanoylphorbol Acetate	85-121	proline rich transmembrane protein 2	Homo sapiens	240-243
1377951-1	1992	In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA.	Tetradecanoylphorbol Acetate	123-126	fibronectin 1	Homo sapiens	65-76
1377951-1	1992	In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA.	Tetradecanoylphorbol Acetate	123-126	fibronectin 1	Homo sapiens	78-80
1377951-7	1992	In conclusion, we have shown that: (1) sphingosine had a robust effect inhibiting the release of FN from fibroblasts, independent of its action on PKC; (2) TPA treatment of these cells resulted in inhibition of PKA; (3) inhibition of PKA stimulated FN release whereas its activation decreased this release.	Tetradecanoylphorbol Acetate	156-159	fibronectin 1	Homo sapiens	97-99
1377951-7	1992	In conclusion, we have shown that: (1) sphingosine had a robust effect inhibiting the release of FN from fibroblasts, independent of its action on PKC; (2) TPA treatment of these cells resulted in inhibition of PKA; (3) inhibition of PKA stimulated FN release whereas its activation decreased this release.	Tetradecanoylphorbol Acetate	156-159	fibronectin 1	Homo sapiens	249-251
1377951-1	1992	In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA.	Tetradecanoylphorbol Acetate	331-334	fibronectin 1	Homo sapiens	78-80
1377951-1	1992	In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA.	Tetradecanoylphorbol Acetate	331-334	proline rich transmembrane protein 2	Homo sapiens	198-214
1380299-4	1992	The activity of PKC was stimulated by phorbol 12-myristate 13-acetate (PMA) and was inhibited with calphostin C.	Tetradecanoylphorbol Acetate	71-74	proline rich transmembrane protein 2	Homo sapiens	16-19
1618787-10	1992	Treatment of R6 cells with 12-O-tetradecanoyl phorbol 13-acetate (TPA), resulted in the translocation of all four PKC isozymes to the membrane fraction, and the subsequent down-regulation of cPKC alpha, nPKC zeta, and nPKC delta, nPKC epsilon, however, was only partially down-regulated in response to long-term TPA exposure.	Tetradecanoylphorbol Acetate	27-64	protein kinase C, epsilon	Rattus norvegicus	230-242
1618788-7	1992	Furthermore, we demonstrated that overproduction of an exogenous cPKC beta I isoform in these cells (R6-PKC3) altered the TPA-induced down-regulation of nPKC delta and nPKC epsilon.	Tetradecanoylphorbol Acetate	122-125	protein kinase C, epsilon	Rattus norvegicus	168-180
1618787-10	1992	Treatment of R6 cells with 12-O-tetradecanoyl phorbol 13-acetate (TPA), resulted in the translocation of all four PKC isozymes to the membrane fraction, and the subsequent down-regulation of cPKC alpha, nPKC zeta, and nPKC delta, nPKC epsilon, however, was only partially down-regulated in response to long-term TPA exposure.	Tetradecanoylphorbol Acetate	66-69	protein kinase C, epsilon	Rattus norvegicus	230-242
1618329-0	1992	Transcriptional activation of the gene for the large subunit of human m-calpain by 12-o-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	83-120	calpain 2	Homo sapiens	70-79
1618329-1	1992	The effect of the treatment of HeLa cells with a tumor-promoting phorbol ester, 12-o-tetradecanoyl-phorbol-13-acetate (TPA) on the expression of the genes for the calpain family has been examined.	Tetradecanoylphorbol Acetate	80-117	calpain 2	Homo sapiens	163-170
1618329-1	1992	The effect of the treatment of HeLa cells with a tumor-promoting phorbol ester, 12-o-tetradecanoyl-phorbol-13-acetate (TPA) on the expression of the genes for the calpain family has been examined.	Tetradecanoylphorbol Acetate	119-122	calpain 2	Homo sapiens	163-170
1618329-2	1992	Among the mRNAs for the calpain family, only the mRNA for the large subunit of human m-calpain (calpain mL) was specifically induced by treatment of cells with TPA, suggesting its specific function in response to cellular stimuli.	Tetradecanoylphorbol Acetate	160-163	calpain 2	Homo sapiens	24-31
1618329-2	1992	Among the mRNAs for the calpain family, only the mRNA for the large subunit of human m-calpain (calpain mL) was specifically induced by treatment of cells with TPA, suggesting its specific function in response to cellular stimuli.	Tetradecanoylphorbol Acetate	160-163	calpain 2	Homo sapiens	85-94
1599436-5	1992	Phorbol 12-myristate 13-acetate or Ca2+ alone can also stimulate PLD, but to a limited extent.	Tetradecanoylphorbol Acetate	0-31	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	65-68
1317858-2	1992	DNA topoisomerase I phosphorylation was stimulated 4-fold by 2 h of TPA treatment (TPA at 100 ng/ml maximally enhanced phosphorylation).	Tetradecanoylphorbol Acetate	68-71	topoisomerase (DNA) I	Mus musculus	0-19
1317858-2	1992	DNA topoisomerase I phosphorylation was stimulated 4-fold by 2 h of TPA treatment (TPA at 100 ng/ml maximally enhanced phosphorylation).	Tetradecanoylphorbol Acetate	83-86	topoisomerase (DNA) I	Mus musculus	0-19
1317858-3	1992	Purified DNA topoisomerase I was phosphorylated in vitro in a Ca2+ and phospholipid-dependent fashion by types I, II, and III protein kinase C. The phosphorylation reaction was stimulated by TPA and had an apparent K(m) of 0.4 microM.	Tetradecanoylphorbol Acetate	191-194	topoisomerase (DNA) I	Mus musculus	9-28
1317858-5	1992	The major tryptic phosphopeptides from DNA topoisomerase I in TPA-treated fibroblasts and phosphorylated by protein kinase C comigrated in thin-layer electrophoresis.	Tetradecanoylphorbol Acetate	62-65	topoisomerase (DNA) I	Mus musculus	39-58
1317858-6	1992	The half-life of incorporated phosphate on DNA topoisomerase I was 40 min in both TPA-treated and control cells.	Tetradecanoylphorbol Acetate	82-85	topoisomerase (DNA) I	Mus musculus	43-62
1317858-7	1992	These results suggest that phosphorylation is a mechanism for activating DNA topoisomerase I in fibroblasts treated with TPA and that protein kinase C functions in the phosphorylation.	Tetradecanoylphorbol Acetate	121-124	topoisomerase (DNA) I	Mus musculus	73-92
1376114-4	1992	Newly expressed TSP receptors are not derived from easily mobilized specific granules since agents that trigger some specific granule release [phorbol myristate acetate (PMA), FMLP or ionophore A23187 alone] do not increase TSP receptor expression.	Tetradecanoylphorbol Acetate	170-173	thrombospondin 1	Homo sapiens	16-19
1376114-8	1992	Using agonists that cause release of specific granules, or both specific granules and azurophil granules, we determined that DIDS blocked the release of PMA-mobilized specific granules and cytochalasin B plus FMLP- or cytochalasin B plus ionophore A23187-mobilized myeloperoxidase-containing azurophil granules but not specific granules mobilized by cytochalasin B plus FMLP or cytochalasin B plus ionophore A23187.	Tetradecanoylphorbol Acetate	153-156	myeloperoxidase	Homo sapiens	265-280
1376114-8	1992	Using agonists that cause release of specific granules, or both specific granules and azurophil granules, we determined that DIDS blocked the release of PMA-mobilized specific granules and cytochalasin B plus FMLP- or cytochalasin B plus ionophore A23187-mobilized myeloperoxidase-containing azurophil granules but not specific granules mobilized by cytochalasin B plus FMLP or cytochalasin B plus ionophore A23187.	Tetradecanoylphorbol Acetate	153-156	formyl peptide receptor 1	Homo sapiens	370-374
1317858-0	1992	DNA topoisomerase I phosphorylation in murine fibroblasts treated with 12-O-tetradecanoylphorbol-13-acetate and in vitro by protein kinase.	Tetradecanoylphorbol Acetate	71-107	topoisomerase (DNA) I	Mus musculus	0-19
1317858-1	1992	The phosphorylation of DNA topoisomerase I in quiescent murine 3T3-L1 fibroblasts treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) was characterized by in vivo labeling with [32P] orthophosphate and immunoprecipitation with a scleroderma anti-DNA topoisomerase I autoantibody.	Tetradecanoylphorbol Acetate	114-150	topoisomerase (DNA) I	Mus musculus	23-42
1317858-1	1992	The phosphorylation of DNA topoisomerase I in quiescent murine 3T3-L1 fibroblasts treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) was characterized by in vivo labeling with [32P] orthophosphate and immunoprecipitation with a scleroderma anti-DNA topoisomerase I autoantibody.	Tetradecanoylphorbol Acetate	152-155	topoisomerase (DNA) I	Mus musculus	23-42
1572412-0	1992	Specific increase in calcium-activated neutral protease with low calcium sensitivity (m-calpain) in proerythroblastic K562 cell line cells induced to differentiation by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	169-200	calpain 2	Homo sapiens	86-95
1375120-4	1992	Activation of 173 and 183 B-CLL cells by phorbol esters (12-O-tetradecanoylphorbol-13-acetate [TPA]) to IgM secretion without concomitant DNA synthesis resulted in a rapid but transient downregulation of bcl-2 expression.	Tetradecanoylphorbol Acetate	57-93	BCL2 apoptosis regulator	Homo sapiens	204-209
1375120-4	1992	Activation of 173 and 183 B-CLL cells by phorbol esters (12-O-tetradecanoylphorbol-13-acetate [TPA]) to IgM secretion without concomitant DNA synthesis resulted in a rapid but transient downregulation of bcl-2 expression.	Tetradecanoylphorbol Acetate	95-98	BCL2 apoptosis regulator	Homo sapiens	204-209
1350981-5	1992	In contrast, CD4+ T cells produced IL-2 when cultured with CD8+ CHO cells and co-stimulated with phorbol myristate acetate (PMA) or mAb to CD3 or CD28.	Tetradecanoylphorbol Acetate	97-122	T-cell surface glycoprotein CD4	Cricetulus griseus	13-16
1350981-5	1992	In contrast, CD4+ T cells produced IL-2 when cultured with CD8+ CHO cells and co-stimulated with phorbol myristate acetate (PMA) or mAb to CD3 or CD28.	Tetradecanoylphorbol Acetate	124-127	T-cell surface glycoprotein CD4	Cricetulus griseus	13-16
1644056-1	1992	Human myeloid leukemia cells (i.e., HL-60, U937, THP-1) which are induced to differentiate along the monocytic pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA), revert back to the undifferentiated phenotype after 3 to 4 weeks.	Tetradecanoylphorbol Acetate	122-158	GLI family zinc finger 2	Homo sapiens	49-54
1572412-2	1992	A remarkable increase in m-calpain (high-Ca(2+)-requiring form) level was detected after PMA-treatment, while there was no significant difference in mu-calpain (low-Ca(2+)-requiring form) level between PMA-treated and untreated K562 cells.	Tetradecanoylphorbol Acetate	89-92	calpain 2	Homo sapiens	25-34
1644056-1	1992	Human myeloid leukemia cells (i.e., HL-60, U937, THP-1) which are induced to differentiate along the monocytic pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA), revert back to the undifferentiated phenotype after 3 to 4 weeks.	Tetradecanoylphorbol Acetate	160-163	GLI family zinc finger 2	Homo sapiens	49-54
1621011-3	1992	The combined effect of IFN-gamma and TPA was blocked by the PKC inhibitor, suggesting that PKC plays an important role in the synergistic action of TPA and IFN-gamma on the inhibition of EGF binding to the cells.	Tetradecanoylphorbol Acetate	37-40	interferon gamma	Homo sapiens	156-165
1621011-3	1992	The combined effect of IFN-gamma and TPA was blocked by the PKC inhibitor, suggesting that PKC plays an important role in the synergistic action of TPA and IFN-gamma on the inhibition of EGF binding to the cells.	Tetradecanoylphorbol Acetate	148-151	interferon gamma	Homo sapiens	23-32
1378917-4	1992	However surface expression of CD20 was induced by phorbol ester (TPA) on both LiLa-1 and LK63 cell lines.	Tetradecanoylphorbol Acetate	65-68	keratin 20	Homo sapiens	30-34
1621011-6	1992	No PKC activity, however, was observed in the WISH cells treated with both IFN-gamma and TPA for 24 h as well as with TPA alone for 24 h, indicating that IFN-gamma may synergize with the second mediator induced by PKC rather than PKC itself in the reduction of EGF binding to WISH cells.	Tetradecanoylphorbol Acetate	89-92	interferon gamma	Homo sapiens	154-163
1378917-9	1992	Following exposure to TPA the 50-55 kD species was reduced over 48-72 h while the level of the p33-37 CD20 protein was increased.	Tetradecanoylphorbol Acetate	22-25	keratin 20	Homo sapiens	102-106
1621011-7	1992	In addition, IFN-gamma showed the synergistic action with calcium ionophores on the reduction of EGF binding to the cells, suggesting that Ca2+ may be one of the second mediators which was induced by TPA and which cooperated with IFN-gamma.	Tetradecanoylphorbol Acetate	200-203	interferon gamma	Homo sapiens	13-22
1391235-4	1992	Treatment of the two IL-6-producing melanoma cell lines with interleukin-1 beta, tumor necrosis factor-alpha, or phorbol myristate acetate caused a marked increase in IL-6 production.	Tetradecanoylphorbol Acetate	113-138	interleukin 6	Homo sapiens	21-25
1391235-4	1992	Treatment of the two IL-6-producing melanoma cell lines with interleukin-1 beta, tumor necrosis factor-alpha, or phorbol myristate acetate caused a marked increase in IL-6 production.	Tetradecanoylphorbol Acetate	113-138	interleukin 6	Homo sapiens	167-171
1621011-7	1992	In addition, IFN-gamma showed the synergistic action with calcium ionophores on the reduction of EGF binding to the cells, suggesting that Ca2+ may be one of the second mediators which was induced by TPA and which cooperated with IFN-gamma.	Tetradecanoylphorbol Acetate	200-203	interferon gamma	Homo sapiens	230-239
1321770-1	1992	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) is a potent activator of protein kinase C (PKC) and is known to affect a variety of biochemical processes in human breast cancer cells.	Tetradecanoylphorbol Acetate	18-54	proline rich transmembrane protein 2	Homo sapiens	86-102
1319016-3	1992	A short-term treatment of cells with PMA did however result in a 5-fold transient increase in VIP mRNA; prior differentiation with retinoic acid or dBcAMP diminished this effect.	Tetradecanoylphorbol Acetate	37-40	vasoactive intestinal peptide	Homo sapiens	94-97
1321770-1	1992	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) is a potent activator of protein kinase C (PKC) and is known to affect a variety of biochemical processes in human breast cancer cells.	Tetradecanoylphorbol Acetate	18-54	proline rich transmembrane protein 2	Homo sapiens	104-107
1321770-1	1992	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) is a potent activator of protein kinase C (PKC) and is known to affect a variety of biochemical processes in human breast cancer cells.	Tetradecanoylphorbol Acetate	56-59	proline rich transmembrane protein 2	Homo sapiens	86-102
1321770-1	1992	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) is a potent activator of protein kinase C (PKC) and is known to affect a variety of biochemical processes in human breast cancer cells.	Tetradecanoylphorbol Acetate	56-59	proline rich transmembrane protein 2	Homo sapiens	104-107
1377325-4	1992	In 32P-labeled intact KB-V1 cells, P-glycoprotein phosphorylation was stimulated by both 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of PKC, and okadaic acid.	Tetradecanoylphorbol Acetate	89-125	ATP binding cassette subfamily B member 1	Homo sapiens	35-49
1377325-4	1992	In 32P-labeled intact KB-V1 cells, P-glycoprotein phosphorylation was stimulated by both 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of PKC, and okadaic acid.	Tetradecanoylphorbol Acetate	89-125	proline rich transmembrane protein 2	Homo sapiens	149-152
1377325-4	1992	In 32P-labeled intact KB-V1 cells, P-glycoprotein phosphorylation was stimulated by both 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of PKC, and okadaic acid.	Tetradecanoylphorbol Acetate	127-130	ATP binding cassette subfamily B member 1	Homo sapiens	35-49
1377325-4	1992	In 32P-labeled intact KB-V1 cells, P-glycoprotein phosphorylation was stimulated by both 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of PKC, and okadaic acid.	Tetradecanoylphorbol Acetate	127-130	proline rich transmembrane protein 2	Homo sapiens	149-152
1599493-2	1992	The expression of lyn, a src-related tyrosine kinase, was studied by analysis of the steady-state levels of its transcript during the cell differentiation process induced by retinoic acid, phorbol 12-myristate 13-acetate and 1,25-dihydroxyvitamin D3.	Tetradecanoylphorbol Acetate	189-220	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	18-21
1321770-5	1992	This inhibitory action of TPA on inositol phosphate production was mimicked by diacylglycerol analogues and was reversed by staurosporine, H-7 and tamoxifen, all known inhibitors of PKC.	Tetradecanoylphorbol Acetate	26-29	proline rich transmembrane protein 2	Homo sapiens	182-185
1321770-6	1992	Furthermore, putative down-regulation of PKC by prolonged TPA pretreatment also reversed the inhibitory action of TPA and enhanced BN-induced phosphoinositide hydrolysis.	Tetradecanoylphorbol Acetate	58-61	proline rich transmembrane protein 2	Homo sapiens	41-44
1321770-6	1992	Furthermore, putative down-regulation of PKC by prolonged TPA pretreatment also reversed the inhibitory action of TPA and enhanced BN-induced phosphoinositide hydrolysis.	Tetradecanoylphorbol Acetate	114-117	proline rich transmembrane protein 2	Homo sapiens	41-44
1594606-6	1992	The CD43 anti-adhesion effect was not overcome by treating cells with phorbol 12-myristate 13-acetate, a chemical that increases the binding avidity of leukocyte function-associated antigen 1 for intercellular adhesion molecule 1.	Tetradecanoylphorbol Acetate	70-101	sialophorin	Homo sapiens	4-8
1599455-0	1992	Substrate level modulation of the activity of phospholipase A2 in vitro by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	75-111	phospholipase A2 group IB	Homo sapiens	46-62
1599455-1	1992	The action of porcine pancreatic phospholipase A2 towards fluorescent phospholipid analogs is either enhanced or suppressed by 4 beta-12-O-tetradecanoylphorbol-13- acetate (TPA), depending on the chemical structure of the substrate and the concentration of Ca2+.	Tetradecanoylphorbol Acetate	173-176	phospholipase A2 group IB	Homo sapiens	33-49
1374394-7	1992	Phorbol myristate acetate (PMA), thrombin, or an endoperoxide analog induced the phosphorylation of the 47-kDa substrate of PKC (pleckstrin) found in platelets and HEL cells; preincubation of either HEL cells or platelets with PMA reduced the intracellular Ca2+ rise induced by thrombin.	Tetradecanoylphorbol Acetate	0-25	proline rich transmembrane protein 2	Homo sapiens	124-127
1350225-3	1992	Nuclear run-on studies show that CD18 expression is transcriptionally regulated during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced HL-60 monocytic differentiation.	Tetradecanoylphorbol Acetate	87-123	integrin subunit beta 2	Homo sapiens	33-37
1350225-3	1992	Nuclear run-on studies show that CD18 expression is transcriptionally regulated during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced HL-60 monocytic differentiation.	Tetradecanoylphorbol Acetate	125-128	integrin subunit beta 2	Homo sapiens	33-37
1374394-7	1992	Phorbol myristate acetate (PMA), thrombin, or an endoperoxide analog induced the phosphorylation of the 47-kDa substrate of PKC (pleckstrin) found in platelets and HEL cells; preincubation of either HEL cells or platelets with PMA reduced the intracellular Ca2+ rise induced by thrombin.	Tetradecanoylphorbol Acetate	0-25	coagulation factor II, thrombin	Homo sapiens	278-286
1350225-9	1992	The CD18 promoter fragment was linked to the luciferase reporter gene, electroporated into the U937 monocytic cell line, and its expression increased after exposure to TPA.	Tetradecanoylphorbol Acetate	168-171	integrin subunit beta 2	Homo sapiens	4-8
1374394-7	1992	Phorbol myristate acetate (PMA), thrombin, or an endoperoxide analog induced the phosphorylation of the 47-kDa substrate of PKC (pleckstrin) found in platelets and HEL cells; preincubation of either HEL cells or platelets with PMA reduced the intracellular Ca2+ rise induced by thrombin.	Tetradecanoylphorbol Acetate	27-30	proline rich transmembrane protein 2	Homo sapiens	124-127
1374394-7	1992	Phorbol myristate acetate (PMA), thrombin, or an endoperoxide analog induced the phosphorylation of the 47-kDa substrate of PKC (pleckstrin) found in platelets and HEL cells; preincubation of either HEL cells or platelets with PMA reduced the intracellular Ca2+ rise induced by thrombin.	Tetradecanoylphorbol Acetate	27-30	coagulation factor II, thrombin	Homo sapiens	278-286
1374394-7	1992	Phorbol myristate acetate (PMA), thrombin, or an endoperoxide analog induced the phosphorylation of the 47-kDa substrate of PKC (pleckstrin) found in platelets and HEL cells; preincubation of either HEL cells or platelets with PMA reduced the intracellular Ca2+ rise induced by thrombin.	Tetradecanoylphorbol Acetate	227-230	coagulation factor II, thrombin	Homo sapiens	33-41
1374394-7	1992	Phorbol myristate acetate (PMA), thrombin, or an endoperoxide analog induced the phosphorylation of the 47-kDa substrate of PKC (pleckstrin) found in platelets and HEL cells; preincubation of either HEL cells or platelets with PMA reduced the intracellular Ca2+ rise induced by thrombin.	Tetradecanoylphorbol Acetate	227-230	proline rich transmembrane protein 2	Homo sapiens	124-127
1533654-7	1992	mAb to CD3 and phorbol myristate acetate stimulated an increase in ERK1 and ERK2 MBP kinase activity.	Tetradecanoylphorbol Acetate	15-40	mitogen-activated protein kinase 3	Homo sapiens	67-71
1317101-3	1992	The phorbol ester phorbol 12-myristate-13 acetate (PMA) led to a concentration-dependent inhibition of basal and stimulated EPO formation (ED50 10 nM).	Tetradecanoylphorbol Acetate	18-49	erythropoietin	Homo sapiens	124-127
1533654-7	1992	mAb to CD3 and phorbol myristate acetate stimulated an increase in ERK1 and ERK2 MBP kinase activity.	Tetradecanoylphorbol Acetate	15-40	mitogen-activated protein kinase 1	Homo sapiens	76-80
1317101-6	1992	Recovery of EPO synthesis after removal of PMA took 48-72 h. The effect of PMA on EPO production was mimicked by phorbol 12,13-dibutyrate (ED50 1 microM) but not by 4 alpha-phorbol 12,13-didecanoate.	Tetradecanoylphorbol Acetate	43-46	erythropoietin	Homo sapiens	82-85
1317101-6	1992	Recovery of EPO synthesis after removal of PMA took 48-72 h. The effect of PMA on EPO production was mimicked by phorbol 12,13-dibutyrate (ED50 1 microM) but not by 4 alpha-phorbol 12,13-didecanoate.	Tetradecanoylphorbol Acetate	75-78	erythropoietin	Homo sapiens	12-15
1317101-3	1992	The phorbol ester phorbol 12-myristate-13 acetate (PMA) led to a concentration-dependent inhibition of basal and stimulated EPO formation (ED50 10 nM).	Tetradecanoylphorbol Acetate	51-54	erythropoietin	Homo sapiens	124-127
1317101-6	1992	Recovery of EPO synthesis after removal of PMA took 48-72 h. The effect of PMA on EPO production was mimicked by phorbol 12,13-dibutyrate (ED50 1 microM) but not by 4 alpha-phorbol 12,13-didecanoate.	Tetradecanoylphorbol Acetate	75-78	erythropoietin	Homo sapiens	82-85
1317101-4	1992	This decrease of EPO production, which was apparent already after 1 h of incubation with PMA, reached its maximal effect after 24 h and held on for 72 h. It was paralleled by an inhibition of the increase of EPO mRNA levels in response to stimulation.	Tetradecanoylphorbol Acetate	89-92	erythropoietin	Homo sapiens	17-20
1317101-4	1992	This decrease of EPO production, which was apparent already after 1 h of incubation with PMA, reached its maximal effect after 24 h and held on for 72 h. It was paralleled by an inhibition of the increase of EPO mRNA levels in response to stimulation.	Tetradecanoylphorbol Acetate	89-92	erythropoietin	Homo sapiens	208-211
1375515-4	1992	Phorbol dibutyrate and 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulated PGE2 output up to 20-fold in a concentration-dependent manner with potencies corresponding to their efficacy as PKC activators.	Tetradecanoylphorbol Acetate	23-59	proline rich transmembrane protein 2	Homo sapiens	189-192
1375515-4	1992	Phorbol dibutyrate and 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulated PGE2 output up to 20-fold in a concentration-dependent manner with potencies corresponding to their efficacy as PKC activators.	Tetradecanoylphorbol Acetate	61-64	proline rich transmembrane protein 2	Homo sapiens	189-192
1533323-8	1992	However, this phenomenon was not specific for LPS; 1 microgram/mL IL-1ra inhibited IL-1 beta synthesized in response to human recombinant IL-2 by 44% (P less than .001), toxic shock syndrome toxin-1 by 26% (P less than .05), and phorbol 12-myristate 13-acetate by 76% (P less than .001).	Tetradecanoylphorbol Acetate	229-260	interleukin 1 beta	Homo sapiens	83-92
1320458-4	1992	Moreover, 6 h pretreatment with PMA caused similar effect on the BK-induced inflow to that obtained with PKC inhibitors, whereas 24 h pretreatment was necessary to affect the internal release.	Tetradecanoylphorbol Acetate	32-35	protein kinase C, alpha	Mus musculus	105-108
1627264-6	1992	Preincubation by IL-1 beta enhanced the effect of a secondary challenge with phorbol 12-myristate 13-acetate or formyl-Met-Leu-Phe by 30-40%.	Tetradecanoylphorbol Acetate	77-108	interleukin 1 beta	Homo sapiens	17-26
1320458-6	1992	6 h treatment with PMA induced down-regulation of PKC beta, whereas longer treatment was needed for down-regulation of PKC alpha.	Tetradecanoylphorbol Acetate	19-22	protein kinase C, alpha	Mus musculus	119-128
1567838-4	1992	Lyngbyatoxin A (0.1 microM) like TPA induced a rapid translocation of PKC from the cytosol to the membrane and subsequently led to a sustained decrease in both cytosolic and membrane PKC activity.	Tetradecanoylphorbol Acetate	33-36	protein kinase C alpha	Homo sapiens	70-73
1398515-5	1992	Supernatants of TPA-stimulated Co cells contained the cytokines IL2, IL3, IL4 and IL8, whereas these cytokines were not detected in the supernatants of untreated cells.	Tetradecanoylphorbol Acetate	16-19	interleukin 2	Homo sapiens	64-67
1398515-5	1992	Supernatants of TPA-stimulated Co cells contained the cytokines IL2, IL3, IL4 and IL8, whereas these cytokines were not detected in the supernatants of untreated cells.	Tetradecanoylphorbol Acetate	16-19	interleukin 4	Homo sapiens	74-77
1398515-5	1992	Supernatants of TPA-stimulated Co cells contained the cytokines IL2, IL3, IL4 and IL8, whereas these cytokines were not detected in the supernatants of untreated cells.	Tetradecanoylphorbol Acetate	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
1572907-7	1992	TGF-alpha and the PKC activator tetradecanoyl phorbol 12-myristyl, 13-acetate (TPA) had similar effects on TGF-alpha steady-state mRNA levels, suggesting that PKC activation might be a downstream mediator of TGF-alpha autoinduction.	Tetradecanoylphorbol Acetate	79-82	proline rich transmembrane protein 2	Homo sapiens	18-21
1572907-8	1992	However, down-regulation of more than 90% of keratinocyte PKC activity by bryostatin pretreatment abrogated the induction of TGF-alpha mRNA in response to TPA without affecting the autoinductive response or EGF-stimulated tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	155-158	proline rich transmembrane protein 2	Homo sapiens	58-61
1628900-6	1992	Concentrations of PMA greater than 3 x 10(-9) M caused inhibition of TNF release.	Tetradecanoylphorbol Acetate	18-21	tumor necrosis factor	Homo sapiens	69-72
1314851-5	1992	Phorbol 12-myristate 13-acetate, opsonized zymosan, or FMLP could all be used as triggering stimuli to demonstrate the priming of PMN activation by ANP.	Tetradecanoylphorbol Acetate	0-31	natriuretic peptide A	Homo sapiens	148-151
1373875-6	1992	We have previously demonstrated that c-fgr is transcriptionally activated in U937 cells treated with either 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or cycloheximide (CHX).	Tetradecanoylphorbol Acetate	108-145	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	37-42
1373875-6	1992	We have previously demonstrated that c-fgr is transcriptionally activated in U937 cells treated with either 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or cycloheximide (CHX).	Tetradecanoylphorbol Acetate	147-150	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	37-42
1373875-8	1992	These results suggest that TPA and CHX induce c-fgr mRNA accumulation by different mechanisms.	Tetradecanoylphorbol Acetate	27-30	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	46-51
1591273-3	1992	The maximal effect with PMA (100 nM) was about 50% of the maximal response with CCK (10 nM) or carbachol (100 microM).	Tetradecanoylphorbol Acetate	24-27	cholecystokinin	Homo sapiens	80-83
1567838-4	1992	Lyngbyatoxin A (0.1 microM) like TPA induced a rapid translocation of PKC from the cytosol to the membrane and subsequently led to a sustained decrease in both cytosolic and membrane PKC activity.	Tetradecanoylphorbol Acetate	33-36	protein kinase C alpha	Homo sapiens	183-186
1567838-7	1992	Western blot analyses with monoclonal antibodies to PKC isoforms indicated that reduction in PKC activity by chronic exposure to TPA or lyngbyatoxin A analogues could be explained by downregulation of PKC alpha.	Tetradecanoylphorbol Acetate	129-132	protein kinase C alpha	Homo sapiens	52-55
1567838-7	1992	Western blot analyses with monoclonal antibodies to PKC isoforms indicated that reduction in PKC activity by chronic exposure to TPA or lyngbyatoxin A analogues could be explained by downregulation of PKC alpha.	Tetradecanoylphorbol Acetate	129-132	protein kinase C alpha	Homo sapiens	93-96
1567838-7	1992	Western blot analyses with monoclonal antibodies to PKC isoforms indicated that reduction in PKC activity by chronic exposure to TPA or lyngbyatoxin A analogues could be explained by downregulation of PKC alpha.	Tetradecanoylphorbol Acetate	129-132	protein kinase C alpha	Homo sapiens	201-210
1373168-7	1992	IL-4 most likely utilizes a protein kinase C-independent signal transduction pathway to modify CD20 molecule inasmuch as staurosporine, an inhibitor of protein kinase C, antagonizes phorbol esters (PMA) but not IL-4-induced CD20 down-regulation.	Tetradecanoylphorbol Acetate	198-201	interleukin 4	Homo sapiens	0-4
1312452-8	1992	Coincubation for 4 h with PMA caused a decrease in PTH- and forskolin-induced up-regulation of VDR.	Tetradecanoylphorbol Acetate	26-29	parathyroid hormone	Rattus norvegicus	51-54
1558843-2	1992	Phorbol myristate acetate (PMA), a known activator of protein kinase C, induces a three to four-fold increase in t-PA and PAI-1 release over a period of 24 h, whereas cell-associated t-PA and PAI-1 levels remain relatively stable.	Tetradecanoylphorbol Acetate	0-25	plasminogen activator, tissue type	Homo sapiens	113-117
1558843-2	1992	Phorbol myristate acetate (PMA), a known activator of protein kinase C, induces a three to four-fold increase in t-PA and PAI-1 release over a period of 24 h, whereas cell-associated t-PA and PAI-1 levels remain relatively stable.	Tetradecanoylphorbol Acetate	27-30	plasminogen activator, tissue type	Homo sapiens	113-117
1558843-10	1992	This indicates that protein kinase A activation may inhibit PMA-stimulated t-PA release via a post-transcriptional effect, e.g. inhibition of protein synthesis or activation of protein degradation.	Tetradecanoylphorbol Acetate	60-63	plasminogen activator, tissue type	Homo sapiens	75-79
1314492-6	1992	The ET-1-induced PEt response was at least additive to that induced by phorbol 12-myristate 13-acetate (1 microM).	Tetradecanoylphorbol Acetate	71-102	endothelin 1	Rattus norvegicus	4-8
1586189-2	1992	Besides antibiotics, treatment consisted of tissue type plasminogen activator (tPA) for three days.	Tetradecanoylphorbol Acetate	79-82	plasminogen activator, tissue type	Homo sapiens	44-77
1351422-4	1992	12-O-tetradecanoylphorbol-13-acetate (TPA) induced DNA synthesis in TIG-1, which was reduced only partly by taxol.	Tetradecanoylphorbol Acetate	0-36	retinoic acid receptor responder 1	Homo sapiens	68-73
1351422-4	1992	12-O-tetradecanoylphorbol-13-acetate (TPA) induced DNA synthesis in TIG-1, which was reduced only partly by taxol.	Tetradecanoylphorbol Acetate	38-41	retinoic acid receptor responder 1	Homo sapiens	68-73
1371947-1	1992	The preferential growth of CD3-CD2-CD11a/CD18- thymocytes was obtained by stimulation of CD2-CD3- thymic cells with low doses of PMA (0.5 ng/ml) and subsequent culture in the presence of recombinant interleukin-2 (100 U/ml).	Tetradecanoylphorbol Acetate	129-132	integrin subunit beta 2	Homo sapiens	41-45
1314505-9	1992	Phorbol 12-myristate 13-acetate and PKC stimulated Na-HCO3 cotransporter activity, whereas the inactive analogue, 4 alpha-phorbol, failed to elicit such a stimulation.	Tetradecanoylphorbol Acetate	0-31	solute carrier family 4 member 4	Homo sapiens	51-72
1312452-10	1992	The effect of activation of PKC on VDR is not a general effect, as PMA does not affect basal ornithine decarboxylase activity and potentiates PTH-induced ornithine decarboxylase activity.	Tetradecanoylphorbol Acetate	67-70	parathyroid hormone	Rattus norvegicus	142-145
1347552-4	1992	The pretreatment of monocytes with PMA induced a dose-dependent inhibition of zymosan-stimulated TNF production.	Tetradecanoylphorbol Acetate	35-38	tumor necrosis factor	Homo sapiens	97-100
1372239-4	1992	IL-1 alpha amplified the effect of phorbol myristate acetate to increase the VIP content of chromaffin cells, but antagonized phorbol ester-induced elevation of neurotensin levels.	Tetradecanoylphorbol Acetate	35-60	vasoactive intestinal peptide	Homo sapiens	77-80
1380243-2	1992	Nuclear factors derived from thymocytes activated with phorbol myristate acetate and concanavalin A were tested for their ability to bind to a synthetic radiolabelled probe corresponding to the NF-AT region (-285 to -255) of the IL-2 gene.	Tetradecanoylphorbol Acetate	55-80	interleukin 2	Homo sapiens	229-233
1588792-0	1992	Phorbol myristate acetate-induced expression of high-affinity interleukin 2 receptors and production of interleukin 2 by human acute lymphoblastic leukemia T cells.	Tetradecanoylphorbol Acetate	0-25	interleukin 2	Homo sapiens	62-75
1588792-1	1992	The effect of phorbol myristate acetate (PMA) on the expression of interleukin 2 receptors (IL-2R), production of IL-2 and IL-2-dependent proliferation of acute lymphoblastic leukemia T cells (T-ALL cells) from 10 patients was studied.	Tetradecanoylphorbol Acetate	41-44	interleukin 2	Homo sapiens	92-96
1316854-3	1992	We examined the effects of cholera toxin (CT), an activator of adenylate cyclase, and 12-O-tetradecanoylphorbol acetate (TPA), a phorbol ester protein kinase C activator, on the levels of mRNAs encoding P-450scc and adrenodoxin in JEG-3 choriocarcinoma cells.	Tetradecanoylphorbol Acetate	86-119	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	203-211
1316854-5	1992	TPA also increased P-450scc and adrenodoxin mRNA levels about 3-fold and 1.5-fold above that of control, respectively.	Tetradecanoylphorbol Acetate	0-3	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	19-27
1316854-8	1992	The protein synthesis inhibitor cycloheximide diminished basal, CT-, TPA-, and EGF-stimulated P-450scc mRNA accumulation whereas the opposite was observed for the adrenodoxin mRNA.	Tetradecanoylphorbol Acetate	69-72	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	94-102
1374838-7	1992	The effect of the DHPs was stereospecific; (+)Bay K 8644, a Ca2+ antagonist, inhibited PMA-induced increases in c-fos and NGFI-A mRNAs.	Tetradecanoylphorbol Acetate	87-90	early growth response 1	Rattus norvegicus	122-128
1588792-5	1992	We found that PMA induced the expression of both IL-2R alpha and IL-2R beta chains, as well as IL-2 production by T-ALL cells.	Tetradecanoylphorbol Acetate	14-17	interleukin 2	Homo sapiens	49-53
1588792-8	1992	In two cases tested high-affinity IL-2R on PMA-treated T-ALL cells could internalize 125I-rIL-2 at 37 degrees C. PMA alone enhanced the spontaneous proliferation of T-ALL cells in three cases, whereas a clear synergy between IL-2 and PMA could be detected in three patients" cells.	Tetradecanoylphorbol Acetate	43-46	interleukin 2	Homo sapiens	34-38
1571784-2	1992	The molecular events leading to these responses are not fully understood, but one possible mediator of NGF"s actions is protein kinase C (PKC), which can be directly activated by phorbol esters, including phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	205-230	nerve growth factor	Homo sapiens	103-106
1609122-4	1992	PKC inhibitors, staurosporine and sphingosine, abolished phorbol myristate acetate (PMA) potentiation of TXA2 production which strongly supports the role of PKC in the synergism.	Tetradecanoylphorbol Acetate	57-82	proline rich transmembrane protein 2	Homo sapiens	0-3
1609122-4	1992	PKC inhibitors, staurosporine and sphingosine, abolished phorbol myristate acetate (PMA) potentiation of TXA2 production which strongly supports the role of PKC in the synergism.	Tetradecanoylphorbol Acetate	57-82	proline rich transmembrane protein 2	Homo sapiens	157-160
1609122-4	1992	PKC inhibitors, staurosporine and sphingosine, abolished phorbol myristate acetate (PMA) potentiation of TXA2 production which strongly supports the role of PKC in the synergism.	Tetradecanoylphorbol Acetate	84-87	proline rich transmembrane protein 2	Homo sapiens	0-3
1609122-4	1992	PKC inhibitors, staurosporine and sphingosine, abolished phorbol myristate acetate (PMA) potentiation of TXA2 production which strongly supports the role of PKC in the synergism.	Tetradecanoylphorbol Acetate	84-87	proline rich transmembrane protein 2	Homo sapiens	157-160
1313426-10	1992	Loss of responsiveness to thrombin and TRP42/55 was also observed following addition of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	107-143	coagulation factor II, thrombin	Homo sapiens	26-34
1313426-10	1992	Loss of responsiveness to thrombin and TRP42/55 was also observed following addition of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	107-143	plasminogen activator, tissue type	Homo sapiens	145-148
1571784-2	1992	The molecular events leading to these responses are not fully understood, but one possible mediator of NGF"s actions is protein kinase C (PKC), which can be directly activated by phorbol esters, including phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	232-235	nerve growth factor	Homo sapiens	103-106
1347710-6	1992	MoAbs GoH3 and 450-30, which bind the alpha 6 subunit of VLA-6, significantly reduced adherence of phorbol myristate acetate-stimulated PMNs to laminin-coated surfaces when CD11/CD18-independent adherence was blocked with anti-CD11/CD18 MoAbs.	Tetradecanoylphorbol Acetate	99-124	integrin subunit beta 2	Homo sapiens	178-182
1347710-6	1992	MoAbs GoH3 and 450-30, which bind the alpha 6 subunit of VLA-6, significantly reduced adherence of phorbol myristate acetate-stimulated PMNs to laminin-coated surfaces when CD11/CD18-independent adherence was blocked with anti-CD11/CD18 MoAbs.	Tetradecanoylphorbol Acetate	99-124	integrin subunit beta 2	Homo sapiens	232-236
1531783-1	1992	Treatment of human myeloid leukemia cells (HL-60, U-937, THP-1) with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with differentiation along the monocytic lineage.	Tetradecanoylphorbol Acetate	87-123	GLI family zinc finger 2	Homo sapiens	57-62
1531783-1	1992	Treatment of human myeloid leukemia cells (HL-60, U-937, THP-1) with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with differentiation along the monocytic lineage.	Tetradecanoylphorbol Acetate	125-128	GLI family zinc finger 2	Homo sapiens	57-62
1540391-2	1992	The elastase inhibitors, elastatinal, alpha 1-antitrypsin, and MeO-Suc-(Ala)2-Pro-Val-CH2Cl, significantly inhibited xanthine dehydrogenase to oxidase conversion by phorbol myristate acetate-stimulated neutrophils without inhibition of neutrophil adherence to the endothelial cell monolayer.	Tetradecanoylphorbol Acetate	165-190	serpin family A member 1	Homo sapiens	38-57
1544940-9	1992	The intracellular TGF-beta 1 precursor was prepared from phorbol 12-myristate 13-acetate-treated HEL cells and tested for TGF-beta 1 bioactivity.	Tetradecanoylphorbol Acetate	57-88	transforming growth factor beta 1	Homo sapiens	18-28
1313646-7	1992	Pretreatment with the phorbol ester, phorbol 12-myristate 13-acetate, significantly blunted initial response to BK and to carbachol by 70 and 86%, respectively.	Tetradecanoylphorbol Acetate	37-68	kininogen 1	Canis lupus familiaris	112-114
1544940-1	1992	Transforming growth factor-beta 1 (TGF-beta 1) is synthesized as a latent high molecular weight complex in a human erythroleukemia cell line, HEL, treated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	160-191	transforming growth factor beta 1	Homo sapiens	0-33
1544940-1	1992	Transforming growth factor-beta 1 (TGF-beta 1) is synthesized as a latent high molecular weight complex in a human erythroleukemia cell line, HEL, treated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	160-191	transforming growth factor beta 1	Homo sapiens	35-45
1537859-7	1992	To examine whether PKC-zeta was activated by TPA, PKC activity was evaluated in COS cells transiently over-expressing this isoform.	Tetradecanoylphorbol Acetate	45-48	protein kinase C alpha	Homo sapiens	19-22
1540395-2	1992	Phorbol 12-myristate 13-acetate (PMA), alpha-thrombin, and sodium fluoride (NaF), a direct G-protein activator, produced a rapid and time-dependent translocation of PKC from the cytosol to the membrane.	Tetradecanoylphorbol Acetate	0-31	C-X-C motif chemokine ligand 8	Homo sapiens	76-79
1540395-3	1992	Activation of PKC by brief pretreatment of human umbilical vein endothelial cell (HUVEC) monolayers with PMA resulted in the inhibition of NaF-induced inositol phosphate increases and attenuation of both alpha-thrombin- and NaF-activated increases in intracellular Ca2+ (Ca2+i).	Tetradecanoylphorbol Acetate	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	139-142
1558167-11	1992	The levels of GDH mRNA are also increased by treating cells with adenosine 3",5"-cyclic monophosphate, epinephrine, triiodothyronine, or retinoic acid, whereas treatment with angiotensin II, vasopressin, phorbol 12-myristate 13-acetate, or cycloheximide did not produce an increase.	Tetradecanoylphorbol Acetate	204-235	angiotensinogen	Rattus norvegicus	175-189
1540395-3	1992	Activation of PKC by brief pretreatment of human umbilical vein endothelial cell (HUVEC) monolayers with PMA resulted in the inhibition of NaF-induced inositol phosphate increases and attenuation of both alpha-thrombin- and NaF-activated increases in intracellular Ca2+ (Ca2+i).	Tetradecanoylphorbol Acetate	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	224-227
1374507-9	1992	Conversely, treatment of N1E-115 cells with 100 nM phorbol myristate acetate for 24 h decreased the level of neuromodulin mRNA by 70%.	Tetradecanoylphorbol Acetate	51-76	growth associated protein 43	Mus musculus	109-121
1531456-2	1992	IL-2 production was induced from these cells by pulsing them with mAb to CD3 and costimulating with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	100-125	interleukin 2	Homo sapiens	0-4
1531456-2	1992	IL-2 production was induced from these cells by pulsing them with mAb to CD3 and costimulating with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	127-130	interleukin 2	Homo sapiens	0-4
1531456-7	1992	By contrast, immobilized GaMIg was a potent stimulus for IL-2 production by T cells pulsed with anti-CD3 mAb and costimulated with PMA.	Tetradecanoylphorbol Acetate	131-134	interleukin 2	Homo sapiens	57-61
1737390-6	1992	TPA induced rapid translocation of the PKC-alpha isozyme and PKC activity to the membrane fraction of MCF-7 cells.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	39-48
1737390-6	1992	TPA induced rapid translocation of the PKC-alpha isozyme and PKC activity to the membrane fraction of MCF-7 cells.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	39-42
1616823-7	1992	The hPKC alpha overexpressing cells were able to grow in soft agarose after treatment with phorbol ester such as TPA (12-O-tetradecanoylphorbol 13-acetate).	Tetradecanoylphorbol Acetate	113-116	protein kinase C alpha	Homo sapiens	4-14
1737390-9	1992	Similar effects on PKC-alpha isozyme and PKC activity were seen in a second cell line whose growth was inhibited by TPA but not by bryostatin 1, MDA-MB-468.	Tetradecanoylphorbol Acetate	116-119	protein kinase C alpha	Homo sapiens	19-28
1616823-7	1992	The hPKC alpha overexpressing cells were able to grow in soft agarose after treatment with phorbol ester such as TPA (12-O-tetradecanoylphorbol 13-acetate).	Tetradecanoylphorbol Acetate	118-154	protein kinase C alpha	Homo sapiens	4-14
1737390-9	1992	Similar effects on PKC-alpha isozyme and PKC activity were seen in a second cell line whose growth was inhibited by TPA but not by bryostatin 1, MDA-MB-468.	Tetradecanoylphorbol Acetate	116-119	protein kinase C alpha	Homo sapiens	19-22
1737390-12	1992	Thus, differential actions of bryostatin 1 and TPA on PKC activity and alpha-isoform level in the membrane-associated fraction of MCF-7 and MDA-MB-468 cells may account for the divergent effects of these two agents on cell growth and morphology.	Tetradecanoylphorbol Acetate	47-50	protein kinase C alpha	Homo sapiens	54-57
1740658-2	1992	We report that the Dex-dependent downregulation of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and calcium ionophore-induced activity of the IL-2 enhancer are mediated by glucocorticoid receptor (GR) via a process that requires intact NH2- and COOH-terminal and DNA-binding domains.	Tetradecanoylphorbol Acetate	51-88	nuclear receptor subfamily 3 group C member 1	Homo sapiens	171-194
1544233-2	1992	Most BMT recipient T cells detectably expressed the CD69 surface antigen after 24 h of stimulation with either phorbol 12-myristate 13-acetate (PMA) or anti-CD3 MoAb and PMA, thus indicating that PKC activity is sufficient to induce de novo gene expression.	Tetradecanoylphorbol Acetate	111-142	proline rich transmembrane protein 2	Homo sapiens	196-199
1547018-13	1992	CAT expression was inducible with phorbol-12-myristate-13-acetate (PMA) and full expression was dependent on the presence of intron 1 and sequences upstream from the 2,163-bp flanking DNA.	Tetradecanoylphorbol Acetate	34-65	catalase	Homo sapiens	0-3
1547018-13	1992	CAT expression was inducible with phorbol-12-myristate-13-acetate (PMA) and full expression was dependent on the presence of intron 1 and sequences upstream from the 2,163-bp flanking DNA.	Tetradecanoylphorbol Acetate	67-70	catalase	Homo sapiens	0-3
1545152-4	1992	After 24 h of exposure to PMA, levels for most cytokines declined to baseline, except for IL-6 which appeared as a new transcript.	Tetradecanoylphorbol Acetate	26-29	interleukin 6	Homo sapiens	90-94
1545152-5	1992	PMA-stimulated CMK lines synthesized low levels of TNF-alpha and IL-6, and higher levels of GM-CSF, IL-1 beta, and IL-1 alpha protein.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 9	Homo sapiens	15-18
1545152-5	1992	PMA-stimulated CMK lines synthesized low levels of TNF-alpha and IL-6, and higher levels of GM-CSF, IL-1 beta, and IL-1 alpha protein.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	51-60
1545152-5	1992	PMA-stimulated CMK lines synthesized low levels of TNF-alpha and IL-6, and higher levels of GM-CSF, IL-1 beta, and IL-1 alpha protein.	Tetradecanoylphorbol Acetate	0-3	interleukin 6	Homo sapiens	65-69
1545152-5	1992	PMA-stimulated CMK lines synthesized low levels of TNF-alpha and IL-6, and higher levels of GM-CSF, IL-1 beta, and IL-1 alpha protein.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Homo sapiens	100-109
1400612-7	1992	Furthermore, TPA enhanced the AA release induced by melittin, known as a phospholipase A2 activator.	Tetradecanoylphorbol Acetate	13-16	phospholipase A2 group IB	Homo sapiens	73-89
1311927-3	1992	In CMK cells N-sam/flg transcript level was enhanced by the culture with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	73-109	C-X-C motif chemokine ligand 9	Homo sapiens	3-6
1544236-2	1992	This egress of proteolytic activity, which was upregulated by phorbol 12-myristate 13-acetate (PMA), was found to occur from both the cytoskeleton and membrane fractions of neutrophils and was dependent on the time of incubation of CRP with the cells and the concentration of CRP.	Tetradecanoylphorbol Acetate	62-93	C-reactive protein	Homo sapiens	232-235
1544236-2	1992	This egress of proteolytic activity, which was upregulated by phorbol 12-myristate 13-acetate (PMA), was found to occur from both the cytoskeleton and membrane fractions of neutrophils and was dependent on the time of incubation of CRP with the cells and the concentration of CRP.	Tetradecanoylphorbol Acetate	62-93	C-reactive protein	Homo sapiens	276-279
1544236-2	1992	This egress of proteolytic activity, which was upregulated by phorbol 12-myristate 13-acetate (PMA), was found to occur from both the cytoskeleton and membrane fractions of neutrophils and was dependent on the time of incubation of CRP with the cells and the concentration of CRP.	Tetradecanoylphorbol Acetate	95-98	C-reactive protein	Homo sapiens	232-235
1544236-2	1992	This egress of proteolytic activity, which was upregulated by phorbol 12-myristate 13-acetate (PMA), was found to occur from both the cytoskeleton and membrane fractions of neutrophils and was dependent on the time of incubation of CRP with the cells and the concentration of CRP.	Tetradecanoylphorbol Acetate	95-98	C-reactive protein	Homo sapiens	276-279
1544236-3	1992	Neutrophil kinases activated by PMA are found to be involved in upregulating the activity of the CRP-degrading protease.	Tetradecanoylphorbol Acetate	32-35	C-reactive protein	Homo sapiens	97-100
1544236-4	1992	The apparent molecular weight of the CRP-degrading protease associated with the conditioned medium from PMA-stimulated neutrophils and neutrophil membrane and cytoskeleton preparations, was found by size exclusion chromatography to be 600 kD and migrated on 3-13% SDS-PAGE as four discrete bands to positions corresponding to apparent molecular weights of 209 kD, 316 kD, 398 kD and 501 kD.	Tetradecanoylphorbol Acetate	104-107	C-reactive protein	Homo sapiens	37-40
1735455-0	1992	Stimulation of proliferation of HL60 cells by low concentrations of 12-O-tetradecanoylphorbol-13-acetate and its relationship to the mitogenic effects of insulin.	Tetradecanoylphorbol Acetate	68-104	insulin	Homo sapiens	154-161
1735455-3	1992	In contrast, in cells deprived of insulin, which continue to grow at a slow rate, lower concentrations of TPA stimulate proliferation without inducing differentiation.	Tetradecanoylphorbol Acetate	106-109	insulin	Homo sapiens	34-41
1735455-5	1992	Low-TPA becomes progressively less able to stimulate further proliferation as the insulin concentration is increased and is virtually without effect on cells stimulated by an optimal insulin concentration (5 micrograms ml-1).	Tetradecanoylphorbol Acetate	4-7	insulin	Homo sapiens	82-89
1735455-9	1992	The proliferation response to low TPA concentrations provides a useful model for dissecting the signalling pathways that control cell proliferation following stimulation by insulin and activators of protein kinase C.	Tetradecanoylphorbol Acetate	34-37	insulin	Homo sapiens	173-180
1571476-7	1992	Phorbol myristate acetate, which activates PKC and the Ca2+ ionophore A23187, stimulated the release of ir-endothelin-1 and ir-big endothelin-1 in a dose-dependent way, respectively.	Tetradecanoylphorbol Acetate	0-25	endothelin 1	Homo sapiens	107-119
1571476-7	1992	Phorbol myristate acetate, which activates PKC and the Ca2+ ionophore A23187, stimulated the release of ir-endothelin-1 and ir-big endothelin-1 in a dose-dependent way, respectively.	Tetradecanoylphorbol Acetate	0-25	endothelin 1	Homo sapiens	131-143
1545816-1	1992	Activators of protein kinase C, such as 12-O-tetradecanoylphorbol 13-acetate (TPA), are known to regulate the expression of many genes, including the tumor necrosis factor alpha (TNF) gene, by affecting the level or activity of upstream transcription factors.	Tetradecanoylphorbol Acetate	40-76	tumor necrosis factor	Homo sapiens	150-177
1545816-1	1992	Activators of protein kinase C, such as 12-O-tetradecanoylphorbol 13-acetate (TPA), are known to regulate the expression of many genes, including the tumor necrosis factor alpha (TNF) gene, by affecting the level or activity of upstream transcription factors.	Tetradecanoylphorbol Acetate	40-76	tumor necrosis factor	Homo sapiens	179-182
1545816-1	1992	Activators of protein kinase C, such as 12-O-tetradecanoylphorbol 13-acetate (TPA), are known to regulate the expression of many genes, including the tumor necrosis factor alpha (TNF) gene, by affecting the level or activity of upstream transcription factors.	Tetradecanoylphorbol Acetate	78-81	tumor necrosis factor	Homo sapiens	150-177
1545816-1	1992	Activators of protein kinase C, such as 12-O-tetradecanoylphorbol 13-acetate (TPA), are known to regulate the expression of many genes, including the tumor necrosis factor alpha (TNF) gene, by affecting the level or activity of upstream transcription factors.	Tetradecanoylphorbol Acetate	78-81	tumor necrosis factor	Homo sapiens	179-182
1545816-2	1992	To investigate the mechanism whereby TPA activates the TNF promoter, a series of 5"-deletion mutants of the human TNF promoter linked to chloramphenicol acetyltransferase was transfected into U937 human promonocytic cells.	Tetradecanoylphorbol Acetate	37-40	tumor necrosis factor	Homo sapiens	55-58
1545816-3	1992	TPA produced a 7- to 11-fold activation of all TNF promoters tested, even those promoters truncated to contain only the core promoter with no upstream enhancer elements.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	47-50
1545816-4	1992	The proximal TNF promoter containing only 28 nucleotides upstream and 10 nucleotides downstream of the RNA start site confers TPA activation to a variety of unrelated upstream enhancer elements and transcription factors, including Sp1, CTF/NF1, cyclic AMP-response element, GAL-E1a, and GAL-VP16.	Tetradecanoylphorbol Acetate	126-129	tumor necrosis factor	Homo sapiens	13-16
1545816-4	1992	The proximal TNF promoter containing only 28 nucleotides upstream and 10 nucleotides downstream of the RNA start site confers TPA activation to a variety of unrelated upstream enhancer elements and transcription factors, including Sp1, CTF/NF1, cyclic AMP-response element, GAL-E1a, and GAL-VP16.	Tetradecanoylphorbol Acetate	126-129	nuclear factor I C	Homo sapiens	236-239
1545816-4	1992	The proximal TNF promoter containing only 28 nucleotides upstream and 10 nucleotides downstream of the RNA start site confers TPA activation to a variety of unrelated upstream enhancer elements and transcription factors, including Sp1, CTF/NF1, cyclic AMP-response element, GAL-E1a, and GAL-VP16.	Tetradecanoylphorbol Acetate	126-129	neurofibromin 1	Homo sapiens	240-243
1545825-4	1992	In this paper, we report that overexpression of GAP blocks the phorbol ester (tetradecanoyl phorbol acetate [TPA])-induced activation of p42 mitogen-activated protein kinase (p42mapk), c-fos expression, and DNA synthesis.	Tetradecanoylphorbol Acetate	78-107	mitogen-activated protein kinase 1	Mus musculus	137-173
1545825-4	1992	In this paper, we report that overexpression of GAP blocks the phorbol ester (tetradecanoyl phorbol acetate [TPA])-induced activation of p42 mitogen-activated protein kinase (p42mapk), c-fos expression, and DNA synthesis.	Tetradecanoylphorbol Acetate	78-107	mitogen-activated protein kinase 1	Mus musculus	175-182
1545825-4	1992	In this paper, we report that overexpression of GAP blocks the phorbol ester (tetradecanoyl phorbol acetate [TPA])-induced activation of p42 mitogen-activated protein kinase (p42mapk), c-fos expression, and DNA synthesis.	Tetradecanoylphorbol Acetate	109-112	mitogen-activated protein kinase 1	Mus musculus	137-173
1545825-4	1992	In this paper, we report that overexpression of GAP blocks the phorbol ester (tetradecanoyl phorbol acetate [TPA])-induced activation of p42 mitogen-activated protein kinase (p42mapk), c-fos expression, and DNA synthesis.	Tetradecanoylphorbol Acetate	109-112	mitogen-activated protein kinase 1	Mus musculus	175-182
20732100-13	1992	The reduced ability of HEK, compared with MEK, to produce PGE(2) is specific to TPA and is due primarily to insufficient substrate, that is, low levels of arachidonic acid release.	Tetradecanoylphorbol Acetate	80-83	EPH receptor A3	Homo sapiens	23-26
1311927-3	1992	In CMK cells N-sam/flg transcript level was enhanced by the culture with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	111-114	C-X-C motif chemokine ligand 9	Homo sapiens	3-6
1371401-2	1992	Hamster cells transfected with and overexpressing mouse mdr1 or mouse mdr3 exhibit high levels of resistance to TPP+ and TPA+ (20-fold) and somewhat lower levels of resistance to TPMP+ and DDP+ (3-12-fold).	Tetradecanoylphorbol Acetate	121-124	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	56-60
1371401-4	1992	Studies with radiolabeled TPP+ and TPA+ demonstrate that increased resistance to cytotoxic concentrations of these lipophilic cations is correlated quantitatively with a decrease in intracellular accumulation in mdr1- and mdr3-transfected cells.	Tetradecanoylphorbol Acetate	35-38	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	212-216
1740658-2	1992	We report that the Dex-dependent downregulation of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and calcium ionophore-induced activity of the IL-2 enhancer are mediated by glucocorticoid receptor (GR) via a process that requires intact NH2- and COOH-terminal and DNA-binding domains.	Tetradecanoylphorbol Acetate	51-88	nuclear receptor subfamily 3 group C member 1	Homo sapiens	196-198
1740658-2	1992	We report that the Dex-dependent downregulation of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and calcium ionophore-induced activity of the IL-2 enhancer are mediated by glucocorticoid receptor (GR) via a process that requires intact NH2- and COOH-terminal and DNA-binding domains.	Tetradecanoylphorbol Acetate	90-93	interleukin 2	Homo sapiens	141-145
1740658-2	1992	We report that the Dex-dependent downregulation of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and calcium ionophore-induced activity of the IL-2 enhancer are mediated by glucocorticoid receptor (GR) via a process that requires intact NH2- and COOH-terminal and DNA-binding domains.	Tetradecanoylphorbol Acetate	90-93	nuclear receptor subfamily 3 group C member 1	Homo sapiens	171-194
1740658-2	1992	We report that the Dex-dependent downregulation of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and calcium ionophore-induced activity of the IL-2 enhancer are mediated by glucocorticoid receptor (GR) via a process that requires intact NH2- and COOH-terminal and DNA-binding domains.	Tetradecanoylphorbol Acetate	90-93	nuclear receptor subfamily 3 group C member 1	Homo sapiens	196-198
1543755-9	1992	This stimulatory effect of thrombin on the ability of the cytosol was mimicked by 12-O-tetradecanoylphorbol 13-acetate (TPA), but not by the Ca2+ ionophore, ionomycin.	Tetradecanoylphorbol Acetate	82-118	coagulation factor II	Mus musculus	27-35
1543755-9	1992	This stimulatory effect of thrombin on the ability of the cytosol was mimicked by 12-O-tetradecanoylphorbol 13-acetate (TPA), but not by the Ca2+ ionophore, ionomycin.	Tetradecanoylphorbol Acetate	120-123	coagulation factor II	Mus musculus	27-35
1740663-5	1992	NF-kappa B binding activity was inducible by tumor necrosis factor and phorbol myristate acetate in PLB-985.	Tetradecanoylphorbol Acetate	71-96	nuclear factor kappa B subunit 1	Homo sapiens	0-10
1309985-3	1992	The site in HL-60 cells remained unmethylated after retinoic acid- or 12-O-tetradecanoyl-phorbol-13-acetate-induced differentiation that arrests myeloperoxidase synthesis.	Tetradecanoylphorbol Acetate	70-107	myeloperoxidase	Homo sapiens	145-160
1346621-3	1992	In contrast to the predominant hyporesponsive alpha beta + CD4-8- T cells, we observe that a minor subset (1 to 2%) of lpr lymph node CD4-8- cells expresses a TCR-gamma delta and can proliferate upon activation with PMA and ionomycin in the absence of exogenous IL-2.	Tetradecanoylphorbol Acetate	216-219	Fas (TNF receptor superfamily member 6)	Mus musculus	119-122
1550850-3	1992	Maximal insulin effect was reached in 30 min and remained constant up to 12 h. The protein kinase C activators 12-O-tetradecanoyl phorbol 13-acetate (TPA) and phorbol 12,13-dibutyrate (PdBU) promoted an initial rapid stimulation followed by a secondary long-term rise of OMG influx.	Tetradecanoylphorbol Acetate	111-148	insulin	Homo sapiens	8-15
1550850-3	1992	Maximal insulin effect was reached in 30 min and remained constant up to 12 h. The protein kinase C activators 12-O-tetradecanoyl phorbol 13-acetate (TPA) and phorbol 12,13-dibutyrate (PdBU) promoted an initial rapid stimulation followed by a secondary long-term rise of OMG influx.	Tetradecanoylphorbol Acetate	150-153	insulin	Homo sapiens	8-15
1371135-2	1992	After treatment with phorbol ester (PMA) or TNF-alpha, a 20- to 40-fold increase in the level of IL-1 beta mRNA was observed in the HIV-infected PLB-IIIB as compared with the parental PLB-985 cells.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Homo sapiens	97-106
1346100-1	1992	In the present study, we have shown that the addition of culture supernatants from HIV-infected SupT1 cells (T4) but not from noninfected cells markedly increased the production of TNF-alpha by U937 promonocytic cells after stimulation with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	241-272	tumor necrosis factor	Homo sapiens	181-190
1551438-0	1992	Increase of poly(ADP-ribose) polymerase mRNA levels during TPA-induced differentiation of human lymphocytes.	Tetradecanoylphorbol Acetate	59-62	poly(ADP-ribose) polymerase 1	Homo sapiens	12-39
1551438-4	1992	Time course of PBMC stimulation with a non-mitogenic dose of TPA showed an early increase in the accumulation of pADPRP mRNA, which changed at 8-16 h, and remained high for several days thereafter.	Tetradecanoylphorbol Acetate	61-64	poly(ADP-ribose) polymerase 1	Homo sapiens	113-119
1347198-9	1992	We conclude from these data that although PMA-induced ICAM-1 expression may be triggered through activation of protein kinase C, ICAM-1 induction by IL-1 beta, TNF-alpha, or LPS may involve distinct regulatory pathway(s).	Tetradecanoylphorbol Acetate	42-45	tumor necrosis factor	Homo sapiens	160-169
1346100-1	1992	In the present study, we have shown that the addition of culture supernatants from HIV-infected SupT1 cells (T4) but not from noninfected cells markedly increased the production of TNF-alpha by U937 promonocytic cells after stimulation with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	274-277	tumor necrosis factor	Homo sapiens	181-190
1346100-4	1992	Further, TNF-alpha produced by U937 cells following stimulation with PMA plus lipopolysaccharide or with phytohemagglutinin induced lysis of HIV-infected T cells.	Tetradecanoylphorbol Acetate	69-72	tumor necrosis factor	Homo sapiens	9-18
1370499-11	1992	On the other hand, PMA-induced actin assembly was inhibited by long-chain fatty acid coenzyme A esters, known inhibitors of nuclear PKC (nPKC).	Tetradecanoylphorbol Acetate	19-22	proline rich transmembrane protein 2	Homo sapiens	132-135
1370843-4	1992	Human recombinant (hr) bFGF could replace TPA in the NHM growth medium.	Tetradecanoylphorbol Acetate	42-45	fibroblast growth factor 2	Homo sapiens	23-27
1370798-6	1992	When cycloheximide (75 microM) was included along with forskolin, PMA, or forskolin plus PMA for a period of 10 h, the increase in NPY medium content was abolished.	Tetradecanoylphorbol Acetate	66-69	neuropeptide Y	Rattus norvegicus	131-134
1370798-6	1992	When cycloheximide (75 microM) was included along with forskolin, PMA, or forskolin plus PMA for a period of 10 h, the increase in NPY medium content was abolished.	Tetradecanoylphorbol Acetate	89-92	neuropeptide Y	Rattus norvegicus	131-134
1370798-9	1992	When the presence of Act-D was limited to 0-24, 6-24, or 12-24 h, and forskolin plus PMA were included for the entire 24-h period, the increase in NPY content was inhibited by 94%, 57%, and 12%, respectively.	Tetradecanoylphorbol Acetate	85-88	neuropeptide Y	Rattus norvegicus	147-150
1309816-6	1992	Scatchard analysis indicates that, as for TPA, the effect of insulin can be accounted for by a loss of the high affinity binding of EGF to HER K721A.	Tetradecanoylphorbol Acetate	42-45	insulin	Homo sapiens	61-68
1370499-12	1992	We conclude that PMA-induced actin assembly is unlikely to be mediated by the conventional isoforms of PKC, but may be mediated by novel isoforms of the kinase such as nPKC.	Tetradecanoylphorbol Acetate	17-20	proline rich transmembrane protein 2	Homo sapiens	103-106
1734039-8	1992	Our results indicate a complex pattern of regulation of the different TGF-beta genes by themselves as well as by PDGF, EGF, IL-1, dexamethasone, TPA, and retinoic acid in chicken embryo cells.	Tetradecanoylphorbol Acetate	145-148	transforming growth factor beta 1	Homo sapiens	70-78
1732379-7	1992	In the presence of 0.1 microM PMA or 10(-6) M FMLP, the OD590 values averaged 0.88 +/- 0.1 and 0.75 +/- 0.12, respectively.	Tetradecanoylphorbol Acetate	30-33	formyl peptide receptor 1	Homo sapiens	46-50
1370514-8	1992	Stimulation with Con A also induced very low or no measurable levels of IL-2 and IFN-gamma, whereas activation with TPA and the calcium ionophore A23187 resulted in the production of high levels of IL-4, IL-5, IL-2, and IFN-gamma.	Tetradecanoylphorbol Acetate	116-119	interleukin 4	Homo sapiens	198-202
1370514-8	1992	Stimulation with Con A also induced very low or no measurable levels of IL-2 and IFN-gamma, whereas activation with TPA and the calcium ionophore A23187 resulted in the production of high levels of IL-4, IL-5, IL-2, and IFN-gamma.	Tetradecanoylphorbol Acetate	116-119	interleukin 2	Homo sapiens	210-214
1370514-8	1992	Stimulation with Con A also induced very low or no measurable levels of IL-2 and IFN-gamma, whereas activation with TPA and the calcium ionophore A23187 resulted in the production of high levels of IL-4, IL-5, IL-2, and IFN-gamma.	Tetradecanoylphorbol Acetate	116-119	interferon gamma	Homo sapiens	220-229
1313283-5	1992	Treatment of the cells with the combination of phorbol myristate acetate (PMA) and A23187 for 5 h led to induction of ET-1 production in all cases tested.	Tetradecanoylphorbol Acetate	47-72	endothelin 1	Rattus norvegicus	118-122
1313283-5	1992	Treatment of the cells with the combination of phorbol myristate acetate (PMA) and A23187 for 5 h led to induction of ET-1 production in all cases tested.	Tetradecanoylphorbol Acetate	74-77	endothelin 1	Rattus norvegicus	118-122
1370476-5	1992	These results suggest that the inhibition of PtdIns 4,5-P2 hydrolysis by PMA and cAMP is attributable to reduced tyrosine phosphorylation of PLC-gamma 1.	Tetradecanoylphorbol Acetate	73-76	phospholipase C gamma 1	Homo sapiens	141-152
1312697-2	1992	This phosphorylation can be rapidly increased either by treatment with the protein kinase C (PKC) activator phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or by inhibition of serine/threonine protein phosphatases with okadaic acid.	Tetradecanoylphorbol Acetate	122-159	proline rich transmembrane protein 2	Homo sapiens	75-91
1312697-2	1992	This phosphorylation can be rapidly increased either by treatment with the protein kinase C (PKC) activator phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or by inhibition of serine/threonine protein phosphatases with okadaic acid.	Tetradecanoylphorbol Acetate	122-159	proline rich transmembrane protein 2	Homo sapiens	93-96
1370476-6	1992	Treatment of Jurkat cells with PMA or forskolin stimulated the phosphorylation of PLC-gamma 1 at serine 1248.	Tetradecanoylphorbol Acetate	31-34	phospholipase C gamma 1	Homo sapiens	82-93
1370476-7	1992	PMA treatment also elicited the phosphorylation of PLC-gamma 1 at an unidentified serine site.	Tetradecanoylphorbol Acetate	0-3	phospholipase C gamma 1	Homo sapiens	51-62
1370476-8	1992	Phosphopeptide map analysis indicated that the sites of PLC-gamma 1 phosphorylated in Jurkat cells treated with PMA and forskolin are the same as those phosphorylated in vitro by protein kinase C (PKC) and cAMP-dependent protein kinase (PKA), respectively.	Tetradecanoylphorbol Acetate	112-115	phospholipase C gamma 1	Homo sapiens	56-67
1730737-2	1992	NF-kappa B activation by phorbol 12-myristate 13-acetate (PMA) and interleukin-1 was inhibited by staurosporin.	Tetradecanoylphorbol Acetate	25-56	nuclear factor kappa B subunit 1	Homo sapiens	0-10
1730737-2	1992	NF-kappa B activation by phorbol 12-myristate 13-acetate (PMA) and interleukin-1 was inhibited by staurosporin.	Tetradecanoylphorbol Acetate	58-61	nuclear factor kappa B subunit 1	Homo sapiens	0-10
1734879-1	1992	Preexposure of human monocytes to recombinant human interleukin-4 (IL-4) suppressed the respiratory burst response to a number of different stimuli, including phorbol myristate acetate, zymosan, platelet-activating factor and the chemotactic peptide, f-met-leu-phe.	Tetradecanoylphorbol Acetate	159-184	interleukin 4	Homo sapiens	52-65
1370476-8	1992	Phosphopeptide map analysis indicated that the sites of PLC-gamma 1 phosphorylated in Jurkat cells treated with PMA and forskolin are the same as those phosphorylated in vitro by protein kinase C (PKC) and cAMP-dependent protein kinase (PKA), respectively.	Tetradecanoylphorbol Acetate	112-115	proline rich transmembrane protein 2	Homo sapiens	197-200
1370479-14	1992	Treatment of human KB epidermoid carcinoma cells with phorbol 12-myristate 13-acetate (PMA) lead to a rapid induction of GCF RNA after 1 h and a decline to lower than control levels after 6 h. Epidermal growth factor receptor mRNAs were not increased by PMA until 2 h after treatment and were at their highest level only after GCF mRNAs were decreased.	Tetradecanoylphorbol Acetate	54-85	epidermal growth factor receptor	Homo sapiens	193-225
1730737-7	1992	Although protein kinase C stimulation by PMA inhibited NF-kappa B activation by TNF-alpha, its action mechanism may be different from that of the staurosporin-sensitive factor.	Tetradecanoylphorbol Acetate	41-44	nuclear factor kappa B subunit 1	Homo sapiens	55-65
1730737-7	1992	Although protein kinase C stimulation by PMA inhibited NF-kappa B activation by TNF-alpha, its action mechanism may be different from that of the staurosporin-sensitive factor.	Tetradecanoylphorbol Acetate	41-44	tumor necrosis factor	Homo sapiens	80-89
1370479-14	1992	Treatment of human KB epidermoid carcinoma cells with phorbol 12-myristate 13-acetate (PMA) lead to a rapid induction of GCF RNA after 1 h and a decline to lower than control levels after 6 h. Epidermal growth factor receptor mRNAs were not increased by PMA until 2 h after treatment and were at their highest level only after GCF mRNAs were decreased.	Tetradecanoylphorbol Acetate	87-90	epidermal growth factor receptor	Homo sapiens	193-225
1377415-3	1992	Stimuli used to promote secretion of prostacyclin and vWF were human alpha-thrombin, histamine, protamine sulphate, poly-L-lysine and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	134-159	von Willebrand factor	Homo sapiens	54-57
1734879-1	1992	Preexposure of human monocytes to recombinant human interleukin-4 (IL-4) suppressed the respiratory burst response to a number of different stimuli, including phorbol myristate acetate, zymosan, platelet-activating factor and the chemotactic peptide, f-met-leu-phe.	Tetradecanoylphorbol Acetate	159-184	interleukin 4	Homo sapiens	67-71
1310016-4	1992	Significant inhibition occurred at concentrations as low as 2 x 10(-12) M and was maximal at 1 x 10(-9) M. Inhibition was observed after 6 h and was maximal after 18 h. Inhibition by TNF alpha was probably mediated by protein kinase C, since the phorbol ester PMA mimicked the effect of TNF alpha, and the protein kinase C inhibitor H-7 completely abolished the effect of TNF alpha.	Tetradecanoylphorbol Acetate	260-263	tumor necrosis factor	Homo sapiens	183-192
1617422-4	1992	This accumulation may be totally or partially prevented when PMA-treated glial cells are concomitantly exposed to the protein kinase inhibitors H-7, H-9, and to a lesser degree, HA-1004.	Tetradecanoylphorbol Acetate	61-64	histocompatibility 7	Mus musculus	144-152
1310016-4	1992	Significant inhibition occurred at concentrations as low as 2 x 10(-12) M and was maximal at 1 x 10(-9) M. Inhibition was observed after 6 h and was maximal after 18 h. Inhibition by TNF alpha was probably mediated by protein kinase C, since the phorbol ester PMA mimicked the effect of TNF alpha, and the protein kinase C inhibitor H-7 completely abolished the effect of TNF alpha.	Tetradecanoylphorbol Acetate	260-263	tumor necrosis factor	Homo sapiens	287-296
1310016-4	1992	Significant inhibition occurred at concentrations as low as 2 x 10(-12) M and was maximal at 1 x 10(-9) M. Inhibition was observed after 6 h and was maximal after 18 h. Inhibition by TNF alpha was probably mediated by protein kinase C, since the phorbol ester PMA mimicked the effect of TNF alpha, and the protein kinase C inhibitor H-7 completely abolished the effect of TNF alpha.	Tetradecanoylphorbol Acetate	260-263	tumor necrosis factor	Homo sapiens	287-296
1370467-2	1992	Epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically suppress activities of the promoter and enhancer of the human alpha-fetoprotein (AFP) gene in HuH-7 human hepatoma cells as analyzed by transient transfection assays using the chloramphenicol acetyltransferase gene as a reporter.	Tetradecanoylphorbol Acetate	34-70	alpha fetoprotein	Homo sapiens	155-172
1736894-3	1992	Addition of phorbol 12-myristate-13-acetate or the membrane-permeant diacylglycerol analogue 1-oleoyl-2-acetylglycerol, which are potent activators of PKC, to bovine spermatozoa resulted in stimulation of the acrosome reaction.	Tetradecanoylphorbol Acetate	12-43	proline rich transmembrane protein 2	Homo sapiens	151-154
1345920-8	1992	Finally, IL-4 production could only be induced by stimulation with PMA and ionomycin in either resting or activated CD31- CD4 cells.	Tetradecanoylphorbol Acetate	67-70	interleukin 4	Homo sapiens	9-13
1345920-8	1992	Finally, IL-4 production could only be induced by stimulation with PMA and ionomycin in either resting or activated CD31- CD4 cells.	Tetradecanoylphorbol Acetate	67-70	CD4 molecule	Homo sapiens	122-125
1370467-2	1992	Epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically suppress activities of the promoter and enhancer of the human alpha-fetoprotein (AFP) gene in HuH-7 human hepatoma cells as analyzed by transient transfection assays using the chloramphenicol acetyltransferase gene as a reporter.	Tetradecanoylphorbol Acetate	34-70	alpha fetoprotein	Homo sapiens	174-177
1370467-2	1992	Epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically suppress activities of the promoter and enhancer of the human alpha-fetoprotein (AFP) gene in HuH-7 human hepatoma cells as analyzed by transient transfection assays using the chloramphenicol acetyltransferase gene as a reporter.	Tetradecanoylphorbol Acetate	72-75	alpha fetoprotein	Homo sapiens	155-172
1370467-2	1992	Epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically suppress activities of the promoter and enhancer of the human alpha-fetoprotein (AFP) gene in HuH-7 human hepatoma cells as analyzed by transient transfection assays using the chloramphenicol acetyltransferase gene as a reporter.	Tetradecanoylphorbol Acetate	72-75	alpha fetoprotein	Homo sapiens	174-177
1370467-4	1992	Unexpectedly, however, Northern blot analysis revealed that the albumin mRNA level as well as the AFP mRNA level were reduced by treatment with EGF and TPA.	Tetradecanoylphorbol Acetate	152-155	alpha fetoprotein	Homo sapiens	98-101
1370467-5	1992	We propose that in HuH-7 cells, the AFP enhancer stimulates the albumin promoter as well as the AFP promoter; and consequently, inhibition of the AFP enhancer by EGF and TPA results in reduction of both AFP and albumin mRNA levels.	Tetradecanoylphorbol Acetate	170-173	alpha fetoprotein	Homo sapiens	36-39
1370467-5	1992	We propose that in HuH-7 cells, the AFP enhancer stimulates the albumin promoter as well as the AFP promoter; and consequently, inhibition of the AFP enhancer by EGF and TPA results in reduction of both AFP and albumin mRNA levels.	Tetradecanoylphorbol Acetate	170-173	alpha fetoprotein	Homo sapiens	96-99
1370467-5	1992	We propose that in HuH-7 cells, the AFP enhancer stimulates the albumin promoter as well as the AFP promoter; and consequently, inhibition of the AFP enhancer by EGF and TPA results in reduction of both AFP and albumin mRNA levels.	Tetradecanoylphorbol Acetate	170-173	alpha fetoprotein	Homo sapiens	96-99
1730652-4	1992	A prolonged treatment (18 h) of LAK cells with 12-O-tetradecanoylphorbol-13-acetate resulted in the loss of both PKC and LAK cell activity.	Tetradecanoylphorbol Acetate	47-83	protein kinase C, alpha	Mus musculus	113-116
1370467-5	1992	We propose that in HuH-7 cells, the AFP enhancer stimulates the albumin promoter as well as the AFP promoter; and consequently, inhibition of the AFP enhancer by EGF and TPA results in reduction of both AFP and albumin mRNA levels.	Tetradecanoylphorbol Acetate	170-173	alpha fetoprotein	Homo sapiens	96-99
1738590-4	1992	Induction of jun B can be mimicked in wild type P19 EC cells by the synergistic action of the phorbol ester TPA and the calcium ionophore A23187, through activation of signal transduction pathways, that are activated simultaneously by EGF.	Tetradecanoylphorbol Acetate	108-111	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-18
1730605-3	1992	Nuclear extracts from cells stimulated with phorbol 12-myristate 13-acetate and ionomycin, which activate protein kinase C and mimic physiological activation through the T-cell antigen receptor, transcribe an interleukin-2 (IL-2) enhancer (-326 to +24) template 5-fold more efficient than nuclear extracts from resting T-cells and severalfold more efficient than extracts from Jurkat cells treated with phorbol 12-myristate 13-acetate or ionomycin alone.	Tetradecanoylphorbol Acetate	44-75	interleukin 2	Homo sapiens	209-222
1309742-8	1992	Low concentrations (1.5 nM) of PMA enhanced the ability of dbcAMP to induce HL-60 cells to express FPR and FPR transcript, whereas high (15 nM) concentrations of PMA inhibited dbcAMP effects.	Tetradecanoylphorbol Acetate	31-34	formyl peptide receptor 1	Homo sapiens	99-102
1309742-8	1992	Low concentrations (1.5 nM) of PMA enhanced the ability of dbcAMP to induce HL-60 cells to express FPR and FPR transcript, whereas high (15 nM) concentrations of PMA inhibited dbcAMP effects.	Tetradecanoylphorbol Acetate	31-34	formyl peptide receptor 1	Homo sapiens	107-110
1730605-3	1992	Nuclear extracts from cells stimulated with phorbol 12-myristate 13-acetate and ionomycin, which activate protein kinase C and mimic physiological activation through the T-cell antigen receptor, transcribe an interleukin-2 (IL-2) enhancer (-326 to +24) template 5-fold more efficient than nuclear extracts from resting T-cells and severalfold more efficient than extracts from Jurkat cells treated with phorbol 12-myristate 13-acetate or ionomycin alone.	Tetradecanoylphorbol Acetate	44-75	interleukin 2	Homo sapiens	224-228
1730605-3	1992	Nuclear extracts from cells stimulated with phorbol 12-myristate 13-acetate and ionomycin, which activate protein kinase C and mimic physiological activation through the T-cell antigen receptor, transcribe an interleukin-2 (IL-2) enhancer (-326 to +24) template 5-fold more efficient than nuclear extracts from resting T-cells and severalfold more efficient than extracts from Jurkat cells treated with phorbol 12-myristate 13-acetate or ionomycin alone.	Tetradecanoylphorbol Acetate	403-434	interleukin 2	Homo sapiens	209-222
1730605-3	1992	Nuclear extracts from cells stimulated with phorbol 12-myristate 13-acetate and ionomycin, which activate protein kinase C and mimic physiological activation through the T-cell antigen receptor, transcribe an interleukin-2 (IL-2) enhancer (-326 to +24) template 5-fold more efficient than nuclear extracts from resting T-cells and severalfold more efficient than extracts from Jurkat cells treated with phorbol 12-myristate 13-acetate or ionomycin alone.	Tetradecanoylphorbol Acetate	403-434	interleukin 2	Homo sapiens	224-228
1571013-3	1992	They expressed Nef with an Mr of 27,000; the yield could be augmented by incubation with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	108-144	S100 calcium binding protein B	Homo sapiens	15-18
1576354-2	1992	Insulin secretion from isolated islets was studied after consecutive stimulation with alpha-ketoisocaproic acid + glutamine, glucose, forskolin, and 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	149-185	insulin	Homo sapiens	0-7
1371427-0	1992	Phorbol 12-myristate 13-acetate induces resistance of human melanoma cells to natural-killer- and lymphokine-activated-killer-mediated cytotoxicity.	Tetradecanoylphorbol Acetate	0-31	interleukin 2	Homo sapiens	98-108
1421693-3	1992	Using an RNase protection assay, we showed that TPA induced a dose-dependent increase in levels of TGF-beta 1 mRNA that paralleled the inhibitory effect on MCF-7 proliferation.	Tetradecanoylphorbol Acetate	48-51	transforming growth factor beta 1	Homo sapiens	99-109
1421693-7	1992	The induction of TGF-beta 1 mRNA by TPA along with its inhibitory effect on cell proliferation suggests that TGF-beta 1 mediates, at least in part, the inhibitory effect of PKC activation.	Tetradecanoylphorbol Acetate	36-39	transforming growth factor beta 1	Homo sapiens	17-27
1421693-7	1992	The induction of TGF-beta 1 mRNA by TPA along with its inhibitory effect on cell proliferation suggests that TGF-beta 1 mediates, at least in part, the inhibitory effect of PKC activation.	Tetradecanoylphorbol Acetate	36-39	transforming growth factor beta 1	Homo sapiens	109-119
1733560-4	1992	Acute thrombin treatment for 24 h resulted in small but statistically significant (P less than 0.05) increases in morphological transformation with or without promotion by phorbol myristate acetate, indicating that thrombin can act as a weak initiator or complete carcinogen in this test system.	Tetradecanoylphorbol Acetate	172-197	coagulation factor II, thrombin	Homo sapiens	6-14
1511462-5	1992	Phytohemagglutinin- and 12-O-tetradecanoylphorbol-13-acetate-induced production of interleukin-2 (IL-2) and NK-cell-mediated cytotoxic activity by peripheral blood mononuclear cells (PBMC) were also substantially decreased in the post-therapy groups.	Tetradecanoylphorbol Acetate	24-60	interleukin 2	Homo sapiens	83-96
1511462-5	1992	Phytohemagglutinin- and 12-O-tetradecanoylphorbol-13-acetate-induced production of interleukin-2 (IL-2) and NK-cell-mediated cytotoxic activity by peripheral blood mononuclear cells (PBMC) were also substantially decreased in the post-therapy groups.	Tetradecanoylphorbol Acetate	24-60	interleukin 2	Homo sapiens	98-102
1733560-4	1992	Acute thrombin treatment for 24 h resulted in small but statistically significant (P less than 0.05) increases in morphological transformation with or without promotion by phorbol myristate acetate, indicating that thrombin can act as a weak initiator or complete carcinogen in this test system.	Tetradecanoylphorbol Acetate	172-197	coagulation factor II, thrombin	Homo sapiens	215-223
1521461-5	1992	12-O-Tetradecanoylphorbol-13-acetate (TPA)-responsive element-like sequences have been identified in upstream regions of the GST-P gene, and oncogene products c-jun and c-fos are suggested to activate the gene.	Tetradecanoylphorbol Acetate	0-36	glutathione S-transferase pi 1	Rattus norvegicus	125-130
1370255-7	1992	Incubation of CD20+ B cells with phorbol myristate acetate (PMA) for 72 hr increased the frequency of CD5 expressing B cells by more than threefold.	Tetradecanoylphorbol Acetate	33-58	keratin 20	Homo sapiens	14-18
1370255-7	1992	Incubation of CD20+ B cells with phorbol myristate acetate (PMA) for 72 hr increased the frequency of CD5 expressing B cells by more than threefold.	Tetradecanoylphorbol Acetate	60-63	keratin 20	Homo sapiens	14-18
1425019-6	1992	High IL-6 production could be induced by stimulating the cells with a combination of phorbol-12-myristate 13-acetate (PMA) and anti-CD28 antibodies.	Tetradecanoylphorbol Acetate	85-116	interleukin 6	Homo sapiens	5-9
1425019-6	1992	High IL-6 production could be induced by stimulating the cells with a combination of phorbol-12-myristate 13-acetate (PMA) and anti-CD28 antibodies.	Tetradecanoylphorbol Acetate	118-121	interleukin 6	Homo sapiens	5-9
1571204-1	1992	We examined the effect of phorbol 12-myristate 13-acetate (PMA) on release of arachidonic acid (AA) and its metabolites in osteoblastic cells in an attempt to study mechanism of the regulation of phospholipase A2 (PLA2) activity.	Tetradecanoylphorbol Acetate	59-62	phospholipase A2 group IB	Homo sapiens	196-212
1571204-1	1992	We examined the effect of phorbol 12-myristate 13-acetate (PMA) on release of arachidonic acid (AA) and its metabolites in osteoblastic cells in an attempt to study mechanism of the regulation of phospholipase A2 (PLA2) activity.	Tetradecanoylphorbol Acetate	59-62	phospholipase A2 group IB	Homo sapiens	214-218
1733630-5	1992	The IL-2R beta chain is constitutively expressed on freshly isolated thymocytes; this expression can be increased in thymocytes activated with Con A in combination with IL-2 or tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	210-213	interleukin 2	Homo sapiens	4-8
1521461-5	1992	12-O-Tetradecanoylphorbol-13-acetate (TPA)-responsive element-like sequences have been identified in upstream regions of the GST-P gene, and oncogene products c-jun and c-fos are suggested to activate the gene.	Tetradecanoylphorbol Acetate	38-41	glutathione S-transferase pi 1	Rattus norvegicus	125-130
1309352-5	1992	Time-dependent increases in P-450AROM mRNA levels in JEG-3 cells were observed for both CT and TPA with maximal effects at 24-48 h. CT and TPA increased P-450AROM mRNA levels in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	95-98	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	28-37
1740106-4	1992	Here we report the identification a novel heterodimeric complex that binds to a kappa B-like, phorbol ester (TPA) responsive DNA sequence, 5"-GGGAAAGTAC-3", in the 5" flanking region of the human urokinase (uPA) gene.	Tetradecanoylphorbol Acetate	109-112	plasminogen activator, urokinase	Homo sapiens	207-210
1335968-5	1992	The half-life for PKC alpha mRNA was approximately 16 h and levels of the mRNA were increased slightly following addition of phorbol myristate acetate (PMA) or transforming growth factor-beta (TGF beta).	Tetradecanoylphorbol Acetate	125-150	protein kinase C alpha	Homo sapiens	18-27
1335968-5	1992	The half-life for PKC alpha mRNA was approximately 16 h and levels of the mRNA were increased slightly following addition of phorbol myristate acetate (PMA) or transforming growth factor-beta (TGF beta).	Tetradecanoylphorbol Acetate	152-155	protein kinase C alpha	Homo sapiens	18-27
1335968-11	1992	In a more detailed study, translocation of PKC-alpha in the presence of PMA was complete by 10 min, and a major decrease in the PKC translocated to the plasma-membrane fraction occurred some time between 2 and 4 h after PMA addition, while a major decrease in the translocated nuclear fraction occurred some time after 6 h. cAMP alone had no effect on the PKC alpha protein level or distribution, nor did it alter the translocation and down-regulation due to PMA exposure.	Tetradecanoylphorbol Acetate	72-75	protein kinase C alpha	Homo sapiens	43-52
1335968-11	1992	In a more detailed study, translocation of PKC-alpha in the presence of PMA was complete by 10 min, and a major decrease in the PKC translocated to the plasma-membrane fraction occurred some time between 2 and 4 h after PMA addition, while a major decrease in the translocated nuclear fraction occurred some time after 6 h. cAMP alone had no effect on the PKC alpha protein level or distribution, nor did it alter the translocation and down-regulation due to PMA exposure.	Tetradecanoylphorbol Acetate	72-75	protein kinase C alpha	Homo sapiens	43-46
1335968-11	1992	In a more detailed study, translocation of PKC-alpha in the presence of PMA was complete by 10 min, and a major decrease in the PKC translocated to the plasma-membrane fraction occurred some time between 2 and 4 h after PMA addition, while a major decrease in the translocated nuclear fraction occurred some time after 6 h. cAMP alone had no effect on the PKC alpha protein level or distribution, nor did it alter the translocation and down-regulation due to PMA exposure.	Tetradecanoylphorbol Acetate	220-223	protein kinase C alpha	Homo sapiens	43-52
1559622-6	1992	The stimulatory action of thrombin or FGF was mimicked by protein kinase C activators, phorbol-12-myristate-13-acetate (PMA) or 1-oleoyl-2-acetyl glycerol, but not by Ca2+ ionophore A23187.	Tetradecanoylphorbol Acetate	87-118	coagulation factor II, thrombin	Homo sapiens	26-34
1559622-6	1992	The stimulatory action of thrombin or FGF was mimicked by protein kinase C activators, phorbol-12-myristate-13-acetate (PMA) or 1-oleoyl-2-acetyl glycerol, but not by Ca2+ ionophore A23187.	Tetradecanoylphorbol Acetate	120-123	coagulation factor II, thrombin	Homo sapiens	26-34
1550865-8	1992	Induction of TNF can occur through a variety of stimuli, including LPS, TPA, cytokines, calcium flux, and oxygen free-radical mechanisms.	Tetradecanoylphorbol Acetate	72-75	tumor necrosis factor	Homo sapiens	13-16
1547025-9	1992	When added to PBMC 1 h after LPS, TNF release was suppressed in a concentration-dependent way and release of biologically active TNF, IL-1 and IL-6 could again be detected for the first time after 4 h. Compound 406 was not able to inhibit phorbol 12-myristate 13-acetate (PMA)-induced TNF and IL-1 release in PBMo which suggests that its modulating effect is LPS-specific.	Tetradecanoylphorbol Acetate	239-270	tumor necrosis factor	Homo sapiens	129-132
1547025-9	1992	When added to PBMC 1 h after LPS, TNF release was suppressed in a concentration-dependent way and release of biologically active TNF, IL-1 and IL-6 could again be detected for the first time after 4 h. Compound 406 was not able to inhibit phorbol 12-myristate 13-acetate (PMA)-induced TNF and IL-1 release in PBMo which suggests that its modulating effect is LPS-specific.	Tetradecanoylphorbol Acetate	239-270	tumor necrosis factor	Homo sapiens	129-132
1547025-9	1992	When added to PBMC 1 h after LPS, TNF release was suppressed in a concentration-dependent way and release of biologically active TNF, IL-1 and IL-6 could again be detected for the first time after 4 h. Compound 406 was not able to inhibit phorbol 12-myristate 13-acetate (PMA)-induced TNF and IL-1 release in PBMo which suggests that its modulating effect is LPS-specific.	Tetradecanoylphorbol Acetate	272-275	tumor necrosis factor	Homo sapiens	129-132
1547025-9	1992	When added to PBMC 1 h after LPS, TNF release was suppressed in a concentration-dependent way and release of biologically active TNF, IL-1 and IL-6 could again be detected for the first time after 4 h. Compound 406 was not able to inhibit phorbol 12-myristate 13-acetate (PMA)-induced TNF and IL-1 release in PBMo which suggests that its modulating effect is LPS-specific.	Tetradecanoylphorbol Acetate	272-275	tumor necrosis factor	Homo sapiens	129-132
1389229-7	1992	By contrast, the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) prolonged survival of FDC-P1 cells on its own and potentiated the response to IFN-gamma or IL-4, although the combination of stimuli did not support long-term growth.	Tetradecanoylphorbol Acetate	44-75	interferon gamma	Mus musculus	160-169
1389229-7	1992	By contrast, the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) prolonged survival of FDC-P1 cells on its own and potentiated the response to IFN-gamma or IL-4, although the combination of stimuli did not support long-term growth.	Tetradecanoylphorbol Acetate	77-80	interferon gamma	Mus musculus	160-169
1309352-5	1992	Time-dependent increases in P-450AROM mRNA levels in JEG-3 cells were observed for both CT and TPA with maximal effects at 24-48 h. CT and TPA increased P-450AROM mRNA levels in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	95-98	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	153-162
1309352-5	1992	Time-dependent increases in P-450AROM mRNA levels in JEG-3 cells were observed for both CT and TPA with maximal effects at 24-48 h. CT and TPA increased P-450AROM mRNA levels in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	139-142	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	28-37
1371491-8	1992	When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha.	Tetradecanoylphorbol Acetate	49-80	interleukin 2	Homo sapiens	194-198
1309352-5	1992	Time-dependent increases in P-450AROM mRNA levels in JEG-3 cells were observed for both CT and TPA with maximal effects at 24-48 h. CT and TPA increased P-450AROM mRNA levels in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	139-142	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	153-162
1371491-8	1992	When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha.	Tetradecanoylphorbol Acetate	49-80	interleukin 4	Homo sapiens	200-204
1371491-8	1992	When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha.	Tetradecanoylphorbol Acetate	49-80	interferon gamma	Homo sapiens	212-221
1371491-8	1992	When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha.	Tetradecanoylphorbol Acetate	49-80	tumor necrosis factor	Homo sapiens	226-235
1371491-8	1992	When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha.	Tetradecanoylphorbol Acetate	82-85	interleukin 2	Homo sapiens	194-198
1371491-8	1992	When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha.	Tetradecanoylphorbol Acetate	82-85	interleukin 4	Homo sapiens	200-204
1371491-8	1992	When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha.	Tetradecanoylphorbol Acetate	82-85	interferon gamma	Homo sapiens	212-221
1371491-8	1992	When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha.	Tetradecanoylphorbol Acetate	82-85	tumor necrosis factor	Homo sapiens	226-235
1309352-9	1992	TPA itself had no clear effect but it approximately doubled the effect of CT on 17 beta-HSD mRNA expression.	Tetradecanoylphorbol Acetate	0-3	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	80-91
1531644-0	1992	Differential regulation by phorbol myristate acetate of IFN-gamma and IL-4 expression in anti-CD3 stimulated mouse spleen cells.	Tetradecanoylphorbol Acetate	27-52	interferon gamma	Mus musculus	56-65
1309352-10	1992	Inhibition of protein synthesis by cycloheximide decreased basal, CT and TPA stimulated P-450AROM mRNA levels but increased the expression of 17 beta-HSD mRNA.	Tetradecanoylphorbol Acetate	73-76	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	88-97
1309352-12	1992	The present results suggest that: 1) induction of P-450AROM mRNA may at least partly be responsible for our previously reported increases in the rate of conversion of androgens to estrogens by CT and TPA in JEG-3 cells; 2) 17 beta-HSD mRNA expression is mainly controlled through a cAMP-dependent mechanism in contrast to the multifactorial control of P-450AROM mRNA; and 3) protein synthesis inhibition by cycloheximide has opposite effects on the mRNA levels of these two key enzymes in placental estrogen metabolism.	Tetradecanoylphorbol Acetate	200-203	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	50-59
1531644-3	1992	In contrast, in the presence of phorbol myristate acetate (PMA), the expression of IFN-gamma was decreased whereas the IL-4 message was dramatically enhanced.	Tetradecanoylphorbol Acetate	32-57	interferon gamma	Mus musculus	83-92
1279947-1	1992	RNA synthesis in melanocytes and nevus cells, and the proliferation of those cells in the presence of nerve growth factor (NGF) and 12-0-tetradecanoyl-phorbol-13-acetate (TPA), were found to correlate with the amount of NGF bound to the chromatin versus the total internalized NGF (n/c NGF = nuclear/cellular ration).	Tetradecanoylphorbol Acetate	171-174	nerve growth factor	Homo sapiens	220-223
1531644-3	1992	In contrast, in the presence of phorbol myristate acetate (PMA), the expression of IFN-gamma was decreased whereas the IL-4 message was dramatically enhanced.	Tetradecanoylphorbol Acetate	59-62	interferon gamma	Mus musculus	83-92
1531763-2	1992	High in vitro growth ability was observed in response to recombinant human IL-2 (rIL-2) and human rIL-7, both in the absence of any co-mitogen and in combination with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	200-203	interleukin 2	Homo sapiens	75-79
1326499-4	1992	Staurosporine and H-7, inhibitors acting on the catalytic domain of PKC, prevented the growth reduction of P3HR-1 cells harboring EBV genomes and the induction of viral DNA synthesis by TPA.	Tetradecanoylphorbol Acetate	186-189	proline rich transmembrane protein 2	Homo sapiens	68-71
1326499-6	1992	From these results it is suggested that PKC is involved in the control of viral DNA synthesis in P3HR-1 cells and that for the inhibition of virus growth, it is more effective to suppress the activity of the catalytic domain of this enzyme than acting on the regulatory domain and competing with PKC activators such as TPA for binding.	Tetradecanoylphorbol Acetate	319-322	proline rich transmembrane protein 2	Homo sapiens	40-43
1284126-4	1992	In contrast, MMP-3, MMP-9 and TIMP-1 activities were markedly stimulated by TPA in most of the tumor cell lines and human umbilical vein endothelial cells (HUVEC), whereas the fibroblast lines were minimally stimulated or unresponsive to TPA.	Tetradecanoylphorbol Acetate	76-79	matrix metallopeptidase 3	Homo sapiens	13-18
1284126-4	1992	In contrast, MMP-3, MMP-9 and TIMP-1 activities were markedly stimulated by TPA in most of the tumor cell lines and human umbilical vein endothelial cells (HUVEC), whereas the fibroblast lines were minimally stimulated or unresponsive to TPA.	Tetradecanoylphorbol Acetate	76-79	TIMP metallopeptidase inhibitor 1	Homo sapiens	30-36
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	0-3	TIMP metallopeptidase inhibitor 1	Homo sapiens	38-44
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	100-116
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	118-121
1284126-14	1992	This activity was maximal at 6 h. An association was observed between AP-1 binding activity and increased expression of MMP-1, MMP-3 and MMP-9, which possess TPA-responsive elements (TRE).	Tetradecanoylphorbol Acetate	158-161	matrix metallopeptidase 3	Homo sapiens	127-132
1284126-15	1992	TPA-sensitive MMPs and TIMP-1 were variably stimulated by biologically relevant cytokines, such as IL-1 and TNF-alpha.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	108-117
1326499-1	1992	12-0-Tetradecanoyl phorbol-13-acetate (TPA) has been widely known as an activator of Epstein-Barr Virus (EBV) replication and is a direct activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	39-42	proline rich transmembrane protein 2	Homo sapiens	169-172
1279947-1	1992	RNA synthesis in melanocytes and nevus cells, and the proliferation of those cells in the presence of nerve growth factor (NGF) and 12-0-tetradecanoyl-phorbol-13-acetate (TPA), were found to correlate with the amount of NGF bound to the chromatin versus the total internalized NGF (n/c NGF = nuclear/cellular ration).	Tetradecanoylphorbol Acetate	171-174	nerve growth factor	Homo sapiens	220-223
1279947-1	1992	RNA synthesis in melanocytes and nevus cells, and the proliferation of those cells in the presence of nerve growth factor (NGF) and 12-0-tetradecanoyl-phorbol-13-acetate (TPA), were found to correlate with the amount of NGF bound to the chromatin versus the total internalized NGF (n/c NGF = nuclear/cellular ration).	Tetradecanoylphorbol Acetate	171-174	nerve growth factor	Homo sapiens	220-223
1279947-4	1992	Removal of TPA from the culture of nevus cells resulted in increased n/c NGF ratio and in a switch from activatory to inhibitory action of NGF.	Tetradecanoylphorbol Acetate	11-14	nerve growth factor	Homo sapiens	73-76
1279947-4	1992	Removal of TPA from the culture of nevus cells resulted in increased n/c NGF ratio and in a switch from activatory to inhibitory action of NGF.	Tetradecanoylphorbol Acetate	11-14	nerve growth factor	Homo sapiens	139-142
1340504-4	1992	Exposure to Phorbol myristate acetate (PMA) dramatically increased binding of both U937 and HL-60 cells to Fn with plateau effects at 10 ng/ml for both cell lines and at 30 and 60 minutes for U937 and HL-60, respectively.	Tetradecanoylphorbol Acetate	12-37	fibronectin 1	Homo sapiens	107-109
1730783-13	1992	H-7 did inhibit induction of TPA responsive element binding by either LPS or PMA.	Tetradecanoylphorbol Acetate	29-32	toll-like receptor 4	Mus musculus	70-73
1284152-2	1992	In vitro, gallopamil caused a dose-dependent reduction in phorbol myristate acetate-stimulated superoxide anion production by neutrophils as measured by the superoxide dismutase inhibited reduction of cytochrome C [concentration of 50% inhibition (IC50) = 9.5 x 10(-6) mol/L].	Tetradecanoylphorbol Acetate	58-83	cytochrome c, somatic	Homo sapiens	201-213
1340504-4	1992	Exposure to Phorbol myristate acetate (PMA) dramatically increased binding of both U937 and HL-60 cells to Fn with plateau effects at 10 ng/ml for both cell lines and at 30 and 60 minutes for U937 and HL-60, respectively.	Tetradecanoylphorbol Acetate	39-42	fibronectin 1	Homo sapiens	107-109
1379817-3	1992	We examined induction of 12-O-tetradecanoylphorbol-13-acetate (TPA)-inducible sequence (TIS) gene expression in Mel-ab melanocytes and in their transformed counterparts, B16 melanoma cells.	Tetradecanoylphorbol Acetate	25-61	programmed cell death 4	Mus musculus	88-91
1737959-2	1992	Both forskolin and PMA (phorbol 12-myristate 13-acetate) increased CRF, AVP and oxytocin release, while dexamethasone and aldosterone only reduced basal secretion of CRF.	Tetradecanoylphorbol Acetate	19-22	arginine vasopressin	Rattus norvegicus	72-75
1737959-2	1992	Both forskolin and PMA (phorbol 12-myristate 13-acetate) increased CRF, AVP and oxytocin release, while dexamethasone and aldosterone only reduced basal secretion of CRF.	Tetradecanoylphorbol Acetate	24-55	arginine vasopressin	Rattus norvegicus	72-75
1371989-4	1992	Human myelomonocytic leukemia THP-1 cells were induced to differentiate into macrophage-like cells by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	117-153	GLI family zinc finger 2	Homo sapiens	30-35
1371989-4	1992	Human myelomonocytic leukemia THP-1 cells were induced to differentiate into macrophage-like cells by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	155-158	GLI family zinc finger 2	Homo sapiens	30-35
1727435-6	1992	Vasoactive intestinal peptide (VIP) reproduced the forskolin-like stimulation but stimulated also other, TPA, and/or Ca2(+)-like protein phosphorylations.	Tetradecanoylphorbol Acetate	105-108	vasoactive intestinal peptide	Homo sapiens	0-29
1727435-6	1992	Vasoactive intestinal peptide (VIP) reproduced the forskolin-like stimulation but stimulated also other, TPA, and/or Ca2(+)-like protein phosphorylations.	Tetradecanoylphorbol Acetate	105-108	vasoactive intestinal peptide	Homo sapiens	31-34
1532844-0	1992	Changes in IgG Fc receptor expression induced by phorbol 12-myristate 13-acetate treatment of THP-1 monocytic leukemia cells.	Tetradecanoylphorbol Acetate	49-80	GLI family zinc finger 2	Homo sapiens	94-99
1532844-1	1992	We studied changes in the three types of Fc gamma receptor (FcR) on the THP-1 human monocytic leukemia cells, after incubation with the phorbol ester, PMA, which has been shown to alter the expression of several genes in these cells.	Tetradecanoylphorbol Acetate	151-154	GLI family zinc finger 2	Homo sapiens	72-77
1379817-3	1992	We examined induction of 12-O-tetradecanoylphorbol-13-acetate (TPA)-inducible sequence (TIS) gene expression in Mel-ab melanocytes and in their transformed counterparts, B16 melanoma cells.	Tetradecanoylphorbol Acetate	63-66	programmed cell death 4	Mus musculus	88-91
1379817-4	1992	Exposure of quiescent Mel-ab cells to the PKC-activating phorbol esters TPA or sapintoxin A at 81 nM for 2 h increased levels of mRNA for six of seven TIS genes examined (twofold to 80-fold increase in steady-state RNA levels for TIS 1, 7, 8, 11, 21, and 28 (c-fos); TIS 10 expression was not affected).	Tetradecanoylphorbol Acetate	72-75	programmed cell death 4	Mus musculus	151-154
1360276-5	1992	We have studied the effects of lymphocyte-activating agents on P-glycoprotein activity in normal human lymphocytes, and found that 12-O-tetradecanoylphorbol-13-acetate (TPA), an efficient agonist of PKC, increased the activity as well as the levels of P-glycoprotein in these cells.	Tetradecanoylphorbol Acetate	131-167	ATP binding cassette subfamily B member 1	Homo sapiens	63-77
1551472-4	1992	At 600 mOsm the rise in both [Ca2+]i and PRL secretion was abolished but PRL secretion induced by 1 microM phorbol 12-myristate 13-acetate was not significantly reduced.	Tetradecanoylphorbol Acetate	107-138	prolactin	Rattus norvegicus	73-76
1360276-5	1992	We have studied the effects of lymphocyte-activating agents on P-glycoprotein activity in normal human lymphocytes, and found that 12-O-tetradecanoylphorbol-13-acetate (TPA), an efficient agonist of PKC, increased the activity as well as the levels of P-glycoprotein in these cells.	Tetradecanoylphorbol Acetate	131-167	ATP binding cassette subfamily B member 1	Homo sapiens	252-266
1360276-5	1992	We have studied the effects of lymphocyte-activating agents on P-glycoprotein activity in normal human lymphocytes, and found that 12-O-tetradecanoylphorbol-13-acetate (TPA), an efficient agonist of PKC, increased the activity as well as the levels of P-glycoprotein in these cells.	Tetradecanoylphorbol Acetate	169-172	ATP binding cassette subfamily B member 1	Homo sapiens	63-77
1360276-5	1992	We have studied the effects of lymphocyte-activating agents on P-glycoprotein activity in normal human lymphocytes, and found that 12-O-tetradecanoylphorbol-13-acetate (TPA), an efficient agonist of PKC, increased the activity as well as the levels of P-glycoprotein in these cells.	Tetradecanoylphorbol Acetate	169-172	ATP binding cassette subfamily B member 1	Homo sapiens	252-266
1360276-6	1992	TPA also increased P-glycoprotein expression in several cell lines derived from different types of leukemias and solid tumors.	Tetradecanoylphorbol Acetate	0-3	ATP binding cassette subfamily B member 1	Homo sapiens	19-33
1450490-4	1992	Thus, treatment of cells with TPA results in a reduction in the levels of c-myb and c-myc mRNA, while the expression of c-fos, c-jun, and junB is greatly enhanced.	Tetradecanoylphorbol Acetate	30-33	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-142
1360276-8	1992	Induction of MDR1 mRNA was apparent as early as two hours after the addition of TPA.	Tetradecanoylphorbol Acetate	80-83	ATP binding cassette subfamily B member 1	Homo sapiens	13-17
1360276-10	1992	The induction of MDR1 expression by TPA and DAG was suppressed by staurosporine, a protein kinase inhibitor.	Tetradecanoylphorbol Acetate	36-39	ATP binding cassette subfamily B member 1	Homo sapiens	17-21
1810598-6	1991	Preincubation of the strips with 10(-7) M PMA for 60 min in Ca(2+)-free buffer, did not affect the 10(-8) M ET-1-induced contraction, but decreased the 5 x 10(-8) M phorbol 12,13-dibutyrate (PDB)-, or the 10(-7) M PMA-induced contraction, and potentiated the contraction induced by 10(-8) M urotensin II.	Tetradecanoylphorbol Acetate	42-45	urotensin 2	Rattus norvegicus	291-303
1492121-5	1992	For most lymphokine genes, a combination of phorbol esters (phorbol 12-myristate 13 acetate, PMA) and calcium ionophores (A23187) is required for their maximal induction.	Tetradecanoylphorbol Acetate	60-91	interleukin 2	Homo sapiens	9-19
1492121-5	1992	For most lymphokine genes, a combination of phorbol esters (phorbol 12-myristate 13 acetate, PMA) and calcium ionophores (A23187) is required for their maximal induction.	Tetradecanoylphorbol Acetate	93-96	interleukin 2	Homo sapiens	9-19
1292481-3	1992	Phorbol ester (20 nm TPA and 1-oleoyl-2-acetyl-sn-glycerol (10 microM (OAG) stimulated newly synthesized casein secretion and potentiated the PRL secretatogue effect.	Tetradecanoylphorbol Acetate	21-24	prolactin	Oryctolagus cuniculus	142-145
1279891-3	1992	Treatment with Bt2cAMP and TPA markedly increased the number of cells immunoreactive to VIP, PHM, neuropeptide Y, Met-enkephalin, substance P and tyrosine hydroxylase and also the contents of VIP and Met-enkephalin in the culture medium.	Tetradecanoylphorbol Acetate	27-30	vasoactive intestinal peptide	Homo sapiens	88-91
1279891-3	1992	Treatment with Bt2cAMP and TPA markedly increased the number of cells immunoreactive to VIP, PHM, neuropeptide Y, Met-enkephalin, substance P and tyrosine hydroxylase and also the contents of VIP and Met-enkephalin in the culture medium.	Tetradecanoylphorbol Acetate	27-30	proopiomelanocortin	Homo sapiens	114-128
1279891-3	1992	Treatment with Bt2cAMP and TPA markedly increased the number of cells immunoreactive to VIP, PHM, neuropeptide Y, Met-enkephalin, substance P and tyrosine hydroxylase and also the contents of VIP and Met-enkephalin in the culture medium.	Tetradecanoylphorbol Acetate	27-30	vasoactive intestinal peptide	Homo sapiens	192-195
1279891-3	1992	Treatment with Bt2cAMP and TPA markedly increased the number of cells immunoreactive to VIP, PHM, neuropeptide Y, Met-enkephalin, substance P and tyrosine hydroxylase and also the contents of VIP and Met-enkephalin in the culture medium.	Tetradecanoylphorbol Acetate	27-30	proopiomelanocortin	Homo sapiens	200-214
1742485-3	1991	Upon differentiation induced by phorbol ester (phorbol 12-myristate 13-acetate [PMA]), metabolites via the COX pathway were increased by 100-fold in ML-1 and THP-1 cells, while the LOX products remained barely detectable.	Tetradecanoylphorbol Acetate	47-78	GLI family zinc finger 2	Homo sapiens	158-163
1742485-3	1991	Upon differentiation induced by phorbol ester (phorbol 12-myristate 13-acetate [PMA]), metabolites via the COX pathway were increased by 100-fold in ML-1 and THP-1 cells, while the LOX products remained barely detectable.	Tetradecanoylphorbol Acetate	80-83	GLI family zinc finger 2	Homo sapiens	158-163
1744113-2	1991	TPA enhanced Mn-SOD mRNA expression in TNF-resistant cell lines including HeLa cells, in which the other reagents also induced expression of the gene, but did not affect TNF-sensitive cells, in which the other stimulators did not alter expression of the gene.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	39-42
1744113-4	1991	TPA-pretreated cells stimulated with TNF, however, expressed Mn-SOD mRNA at about twice the level of TNF-stimulated, TPA-untreated cells.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	37-40
1744113-4	1991	TPA-pretreated cells stimulated with TNF, however, expressed Mn-SOD mRNA at about twice the level of TNF-stimulated, TPA-untreated cells.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	101-104
1744113-4	1991	TPA-pretreated cells stimulated with TNF, however, expressed Mn-SOD mRNA at about twice the level of TNF-stimulated, TPA-untreated cells.	Tetradecanoylphorbol Acetate	117-120	tumor necrosis factor	Homo sapiens	37-40
1744113-5	1991	When protein synthesis was inhibited by cycloheximide during TPA pretreatment, TNF no more enhanced the Mn-SOD mRNA accumulation.	Tetradecanoylphorbol Acetate	61-64	tumor necrosis factor	Homo sapiens	79-82
1744113-8	1991	The other can be activated by stimulation with TNF, interleukin-1, or lipopolysaccharide and in which a protein factor that can be induced by TPA treatment is involved.	Tetradecanoylphorbol Acetate	142-145	tumor necrosis factor	Homo sapiens	47-50
1954393-6	1991	In contrast, lymphokine production in patients treated with immunosuppressive drugs (cyclosporine A, corticosteroids) was abnormal after stimulation with PMA and ionophore, as well as ConA.	Tetradecanoylphorbol Acetate	154-157	interleukin 2	Homo sapiens	13-23
1722214-0	1991	Identification of protein-binding sequences mediating constitutive and 12-O-tetradecanoylphorbol-13-acetate-induced VL30 transcription in cultured mouse and human keratinocytes.	Tetradecanoylphorbol Acetate	71-107	RIKEN cDNA A130040M12 gene	Mus musculus	116-120
1722214-1	1991	A retrovirus-like 30S (VL30) gene induced in mouse epidermis after a single application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was used as a model gene to define mechanisms of transcriptional regulation in keratinocytes.	Tetradecanoylphorbol Acetate	91-127	RIKEN cDNA A130040M12 gene	Mus musculus	23-27
1722214-1	1991	A retrovirus-like 30S (VL30) gene induced in mouse epidermis after a single application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was used as a model gene to define mechanisms of transcriptional regulation in keratinocytes.	Tetradecanoylphorbol Acetate	129-132	RIKEN cDNA A130040M12 gene	Mus musculus	23-27
1722214-3	1991	Deletion mapping of the long terminal repeat region and linking short sequences to a heterologous promoter made it possible to identify a 28-base pair VL30 TPA-responsive element.	Tetradecanoylphorbol Acetate	156-159	RIKEN cDNA A130040M12 gene	Mus musculus	151-155
1722214-4	1991	VL30 TPA-responsive element mediated both basal and TPA-induced transcription in the mouse keratinocyte cell line Balb/MK and in normal human keratinocytes.	Tetradecanoylphorbol Acetate	5-8	RIKEN cDNA A130040M12 gene	Mus musculus	0-4
1722214-4	1991	VL30 TPA-responsive element mediated both basal and TPA-induced transcription in the mouse keratinocyte cell line Balb/MK and in normal human keratinocytes.	Tetradecanoylphorbol Acetate	52-55	RIKEN cDNA A130040M12 gene	Mus musculus	0-4
1722214-5	1991	Gel-retardation and transient transfection experiments indicated that two nuclear factors (VLX and VLY) bind independently to the VL30 TPA-responsive element in juxtaposed positions and that the binding sites collaborate functionally in constitutive and TPA-induced transcription.	Tetradecanoylphorbol Acetate	135-138	RIKEN cDNA A130040M12 gene	Mus musculus	130-134
1722214-5	1991	Gel-retardation and transient transfection experiments indicated that two nuclear factors (VLX and VLY) bind independently to the VL30 TPA-responsive element in juxtaposed positions and that the binding sites collaborate functionally in constitutive and TPA-induced transcription.	Tetradecanoylphorbol Acetate	254-257	RIKEN cDNA A130040M12 gene	Mus musculus	130-134
1764024-8	1991	Phorbol 12-myristate 13-acetate treatment of the cells inhibited LPA-stimulated, but not ET-1-stimulated, inositol phosphate formation in both intact and permeabilized cells, suggesting that the site of protein kinase C-mediated phosphorylation may be blocked in ET-1-stimulated Rat-1 cells.	Tetradecanoylphorbol Acetate	0-31	endothelin 1	Rattus norvegicus	263-267
1666853-9	1991	Inclusion of the protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), in the preincubation medium blocked the stimulatory actions of FSH and forskolin on the induction of P450scc activity; however, PMA-preincubation did not alter the ability of granulosa cells to convert exogenous pregnenolone to progesterone compared to vehicle-pretreated cells.	Tetradecanoylphorbol Acetate	45-76	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	185-192
1666853-9	1991	Inclusion of the protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), in the preincubation medium blocked the stimulatory actions of FSH and forskolin on the induction of P450scc activity; however, PMA-preincubation did not alter the ability of granulosa cells to convert exogenous pregnenolone to progesterone compared to vehicle-pretreated cells.	Tetradecanoylphorbol Acetate	78-81	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	185-192
1666853-9	1991	Inclusion of the protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), in the preincubation medium blocked the stimulatory actions of FSH and forskolin on the induction of P450scc activity; however, PMA-preincubation did not alter the ability of granulosa cells to convert exogenous pregnenolone to progesterone compared to vehicle-pretreated cells.	Tetradecanoylphorbol Acetate	212-215	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	185-192
1747937-3	1991	Relative to solvent-treated controls, the specific activities of epidermal superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were reduced approximately 45, approximately 60 and approximately 24% respectively, 24 h after the fourth or tenth topical application of 1 microgram of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal skin of SENCAR mice.	Tetradecanoylphorbol Acetate	304-340	catalase	Mus musculus	103-111
1747937-3	1991	Relative to solvent-treated controls, the specific activities of epidermal superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were reduced approximately 45, approximately 60 and approximately 24% respectively, 24 h after the fourth or tenth topical application of 1 microgram of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal skin of SENCAR mice.	Tetradecanoylphorbol Acetate	342-345	catalase	Mus musculus	103-111
1747937-6	1991	CAT and SOD activities were also significantly suppressed in the skin adjacent to the papillomas for several weeks following the cessation of TPA promotion, but eventually recovered to the levels measured in age-matched controls.	Tetradecanoylphorbol Acetate	142-145	catalase	Mus musculus	0-3
1779468-4	1991	On the contrary, IL-6 mRNA was detected by the method of RT-PCR, and its expression induced by the addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) could be clearly shown by Northern blotting.	Tetradecanoylphorbol Acetate	111-147	interleukin 6	Homo sapiens	17-21
1836162-4	1991	Similarly, human colostrum inhibited the production of IL-2 by EL4 cells, a murine thymoma line, when stimulated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	118-143	interleukin 2	Homo sapiens	55-59
1661292-2	1991	Peripheral monocytes and myelomonocytic cell lines could be stimulated by LPS or phorbol myristate acetate (PMA) to express IL-1 mRNA.	Tetradecanoylphorbol Acetate	81-106	interleukin 1 beta	Homo sapiens	124-128
1661292-2	1991	Peripheral monocytes and myelomonocytic cell lines could be stimulated by LPS or phorbol myristate acetate (PMA) to express IL-1 mRNA.	Tetradecanoylphorbol Acetate	108-111	interleukin 1 beta	Homo sapiens	124-128
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	Tetradecanoylphorbol Acetate	87-90	interleukin 1 beta	Homo sapiens	189-198
1942242-3	1991	Anti-TNF-alpha antibody suppressed both the constitutive expression of the HIV-1 LTR in BH1 cells and the expression induced by phorbol 12-myristate 13-acetate in U937 cells.	Tetradecanoylphorbol Acetate	128-159	tumor necrosis factor	Homo sapiens	5-14
1665201-5	1991	cAMP has previously been shown to potentiate phorbol 12-myristate 13-acetate-mediated induction of t-PA biosynthesis in HeLa cells and in human endothelial cells.	Tetradecanoylphorbol Acetate	45-76	plasminogen activator, tissue type	Homo sapiens	99-103
1812965-6	1991	Chimeric molecules bearing the cytoplasmic domain of CD4 and the extracellular domain of either the low-density lipoprotein receptor or a major histocompatibility complex (MHC) class I molecule were both internalized in response to phorbol 12-myristate 13-acetate and were subsequently degraded, indicating that the cytoplasmic tail of CD4 contains all the information required for both processes.	Tetradecanoylphorbol Acetate	232-263	CD4 molecule	Homo sapiens	53-56
1812965-6	1991	Chimeric molecules bearing the cytoplasmic domain of CD4 and the extracellular domain of either the low-density lipoprotein receptor or a major histocompatibility complex (MHC) class I molecule were both internalized in response to phorbol 12-myristate 13-acetate and were subsequently degraded, indicating that the cytoplasmic tail of CD4 contains all the information required for both processes.	Tetradecanoylphorbol Acetate	232-263	CD4 molecule	Homo sapiens	336-339
1934072-8	1991	However, pretreatment with PMA for 24 hr prior to IFN-gamma stimulation decreased the IFN-gamma-induced expression of HLA-DR without decreasing IFN-gamma receptor levels.	Tetradecanoylphorbol Acetate	27-30	interferon gamma	Homo sapiens	86-95
1934072-8	1991	However, pretreatment with PMA for 24 hr prior to IFN-gamma stimulation decreased the IFN-gamma-induced expression of HLA-DR without decreasing IFN-gamma receptor levels.	Tetradecanoylphorbol Acetate	27-30	interferon gamma	Homo sapiens	86-95
1721021-5	1991	Prior activation with phorbol 12-myristate 13-acetate (PMA) significantly increased the ability of T cells to up-regulate endothelial ICAM-1 and also induced the expression of both ELAM-1 and VCAM-1.	Tetradecanoylphorbol Acetate	22-53	vascular cell adhesion molecule 1	Homo sapiens	192-198
1721021-5	1991	Prior activation with phorbol 12-myristate 13-acetate (PMA) significantly increased the ability of T cells to up-regulate endothelial ICAM-1 and also induced the expression of both ELAM-1 and VCAM-1.	Tetradecanoylphorbol Acetate	55-58	vascular cell adhesion molecule 1	Homo sapiens	192-198
1819687-6	1991	Controversy exists as to whether PMA activates the remodeling pathway, i.e. the activation of phospholipase A2 and acetyltransferase, or the de novo route through CDPcholine cholinephosphotransferase action on alkylacetylglycerol.	Tetradecanoylphorbol Acetate	33-36	phospholipase A2 group IB	Homo sapiens	94-132
1779468-4	1991	On the contrary, IL-6 mRNA was detected by the method of RT-PCR, and its expression induced by the addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) could be clearly shown by Northern blotting.	Tetradecanoylphorbol Acetate	149-152	interleukin 6	Homo sapiens	17-21
1659812-0	1991	The activity of a beta subtype of protein kinase C purified from nuclei of human neutrophils is enhanced by treatment with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	123-154	amyloid beta precursor protein	Homo sapiens	16-22
1659812-2	1991	Treatment of neutrophils with phorbol 12-myristate 13-acetate (PMA) caused a 3.8-fold increase of nuclear beta PKC activity, while a minor increase of alpha PKC was observed.	Tetradecanoylphorbol Acetate	30-61	proline rich transmembrane protein 2	Homo sapiens	111-114
1779468-7	1991	Both the smg p21A and -B mRNAs were detected in CMK cells using Northern blotting, and their levels were markedly elevated by TPA treatment.	Tetradecanoylphorbol Acetate	126-129	C-X-C motif chemokine ligand 9	Homo sapiens	48-51
1659812-2	1991	Treatment of neutrophils with phorbol 12-myristate 13-acetate (PMA) caused a 3.8-fold increase of nuclear beta PKC activity, while a minor increase of alpha PKC was observed.	Tetradecanoylphorbol Acetate	30-61	proline rich transmembrane protein 2	Homo sapiens	157-160
1779468-9	1991	These findings suggest that smg p21s play an important role during the TPA-induced differentiation of CMK cells.	Tetradecanoylphorbol Acetate	71-74	C-X-C motif chemokine ligand 9	Homo sapiens	102-105
1659812-2	1991	Treatment of neutrophils with phorbol 12-myristate 13-acetate (PMA) caused a 3.8-fold increase of nuclear beta PKC activity, while a minor increase of alpha PKC was observed.	Tetradecanoylphorbol Acetate	63-66	proline rich transmembrane protein 2	Homo sapiens	111-114
1659812-2	1991	Treatment of neutrophils with phorbol 12-myristate 13-acetate (PMA) caused a 3.8-fold increase of nuclear beta PKC activity, while a minor increase of alpha PKC was observed.	Tetradecanoylphorbol Acetate	63-66	proline rich transmembrane protein 2	Homo sapiens	157-160
1660266-2	1991	Diacylglycerol (DG) and its analogue phorbol 12-myristate 13-acetate (PMA) activate the ubiquitous phospholipid/Ca2(+)-dependent protein kinase, protein kinase C (PKC), and cause it to become tightly associated with membranes.	Tetradecanoylphorbol Acetate	37-68	proline rich transmembrane protein 2	Homo sapiens	145-161
1725864-8	1991	In addition, during a 60-min incubation with isolated islets, galanin inhibited insulin secretion induced by forskolin (1 microM), dibutyryl cyclic AMP (1 mM), or TPA (12-O-tetradecanoylphorbol-13-acetate; 0.1 microM).	Tetradecanoylphorbol Acetate	163-166	galanin and GMAP prepropeptide	Mus musculus	62-69
1725864-8	1991	In addition, during a 60-min incubation with isolated islets, galanin inhibited insulin secretion induced by forskolin (1 microM), dibutyryl cyclic AMP (1 mM), or TPA (12-O-tetradecanoylphorbol-13-acetate; 0.1 microM).	Tetradecanoylphorbol Acetate	168-204	galanin and GMAP prepropeptide	Mus musculus	62-69
1660266-2	1991	Diacylglycerol (DG) and its analogue phorbol 12-myristate 13-acetate (PMA) activate the ubiquitous phospholipid/Ca2(+)-dependent protein kinase, protein kinase C (PKC), and cause it to become tightly associated with membranes.	Tetradecanoylphorbol Acetate	37-68	proline rich transmembrane protein 2	Homo sapiens	163-166
1660266-2	1991	Diacylglycerol (DG) and its analogue phorbol 12-myristate 13-acetate (PMA) activate the ubiquitous phospholipid/Ca2(+)-dependent protein kinase, protein kinase C (PKC), and cause it to become tightly associated with membranes.	Tetradecanoylphorbol Acetate	70-73	proline rich transmembrane protein 2	Homo sapiens	145-161
1660266-2	1991	Diacylglycerol (DG) and its analogue phorbol 12-myristate 13-acetate (PMA) activate the ubiquitous phospholipid/Ca2(+)-dependent protein kinase, protein kinase C (PKC), and cause it to become tightly associated with membranes.	Tetradecanoylphorbol Acetate	70-73	proline rich transmembrane protein 2	Homo sapiens	163-166
1660266-4	1991	Phorbol esters such as PMA are not metabolized and induced a prolonged membrane association of PKC.	Tetradecanoylphorbol Acetate	23-26	proline rich transmembrane protein 2	Homo sapiens	95-98
1720402-0	1991	Phorbol 12-myristate-13-acetate (PMA) stimulates a differential expression of cholecystokinin (CCK) and c-fos mRNA in a human neuroblastoma cell line.	Tetradecanoylphorbol Acetate	33-36	cholecystokinin	Homo sapiens	95-98
1720402-4	1991	Treatment with PMA and IBMX for 4-24 hours transiently raised the CCK mRNA level approximately 1.5-3.5 times compared to the controls, and the combination PMA and IBMX had an additive effect and elevated CCK mRNA abundance 1.5-6.5 times.	Tetradecanoylphorbol Acetate	15-18	cholecystokinin	Homo sapiens	66-69
1720402-0	1991	Phorbol 12-myristate-13-acetate (PMA) stimulates a differential expression of cholecystokinin (CCK) and c-fos mRNA in a human neuroblastoma cell line.	Tetradecanoylphorbol Acetate	0-31	cholecystokinin	Homo sapiens	78-93
1720402-0	1991	Phorbol 12-myristate-13-acetate (PMA) stimulates a differential expression of cholecystokinin (CCK) and c-fos mRNA in a human neuroblastoma cell line.	Tetradecanoylphorbol Acetate	0-31	cholecystokinin	Homo sapiens	95-98
1720402-0	1991	Phorbol 12-myristate-13-acetate (PMA) stimulates a differential expression of cholecystokinin (CCK) and c-fos mRNA in a human neuroblastoma cell line.	Tetradecanoylphorbol Acetate	33-36	cholecystokinin	Homo sapiens	78-93
1720402-4	1991	Treatment with PMA and IBMX for 4-24 hours transiently raised the CCK mRNA level approximately 1.5-3.5 times compared to the controls, and the combination PMA and IBMX had an additive effect and elevated CCK mRNA abundance 1.5-6.5 times.	Tetradecanoylphorbol Acetate	15-18	cholecystokinin	Homo sapiens	204-207
1824257-1	1991	FD/PMA is a subclone of the interleukin-3 (IL-3)-dependent, FDC-P1 cell line, which proliferates in response to either 12-O-tetradecanoylphorbol-13 acetate (PMA) or IL-3.	Tetradecanoylphorbol Acetate	119-155	interleukin 3	Mus musculus	28-41
1720402-4	1991	Treatment with PMA and IBMX for 4-24 hours transiently raised the CCK mRNA level approximately 1.5-3.5 times compared to the controls, and the combination PMA and IBMX had an additive effect and elevated CCK mRNA abundance 1.5-6.5 times.	Tetradecanoylphorbol Acetate	155-158	cholecystokinin	Homo sapiens	66-69
1720402-4	1991	Treatment with PMA and IBMX for 4-24 hours transiently raised the CCK mRNA level approximately 1.5-3.5 times compared to the controls, and the combination PMA and IBMX had an additive effect and elevated CCK mRNA abundance 1.5-6.5 times.	Tetradecanoylphorbol Acetate	155-158	cholecystokinin	Homo sapiens	204-207
1824257-1	1991	FD/PMA is a subclone of the interleukin-3 (IL-3)-dependent, FDC-P1 cell line, which proliferates in response to either 12-O-tetradecanoylphorbol-13 acetate (PMA) or IL-3.	Tetradecanoylphorbol Acetate	119-155	interleukin 3	Mus musculus	43-47
1824257-1	1991	FD/PMA is a subclone of the interleukin-3 (IL-3)-dependent, FDC-P1 cell line, which proliferates in response to either 12-O-tetradecanoylphorbol-13 acetate (PMA) or IL-3.	Tetradecanoylphorbol Acetate	3-6	interleukin 3	Mus musculus	28-41
1824257-1	1991	FD/PMA is a subclone of the interleukin-3 (IL-3)-dependent, FDC-P1 cell line, which proliferates in response to either 12-O-tetradecanoylphorbol-13 acetate (PMA) or IL-3.	Tetradecanoylphorbol Acetate	3-6	interleukin 3	Mus musculus	43-47
1824257-1	1991	FD/PMA is a subclone of the interleukin-3 (IL-3)-dependent, FDC-P1 cell line, which proliferates in response to either 12-O-tetradecanoylphorbol-13 acetate (PMA) or IL-3.	Tetradecanoylphorbol Acetate	3-6	interleukin 3	Mus musculus	165-169
1946468-3	1991	Here we show that the PMA-induced differentiation of SH-SY5Y cells grown in a serum-free medium is strongly potentiated by nanomolar concentrations of IGF-I, as judged by morphology and markers for neuronal differentiation--e.g., neuropeptide tyrosine and growth-associated protein 43.	Tetradecanoylphorbol Acetate	22-25	insulin like growth factor 1	Homo sapiens	151-156
1834742-4	1991	Bryostatin (Bryo) and phorbol esters (e.g., 12-O-tetradecanoylphorbol 13-acetate (TPA] are PKC activators with somewhat different immunologic effects.	Tetradecanoylphorbol Acetate	44-80	protein kinase C alpha	Homo sapiens	91-94
1834742-4	1991	Bryostatin (Bryo) and phorbol esters (e.g., 12-O-tetradecanoylphorbol 13-acetate (TPA] are PKC activators with somewhat different immunologic effects.	Tetradecanoylphorbol Acetate	82-85	protein kinase C alpha	Homo sapiens	91-94
1834742-9	1991	Furthermore, Jurkat cells grown continuously in 100 nM TPA regained full proliferative capacity after several weeks in culture and transferrin receptor expression returned to near the level seen in untreated Jurkat cells.	Tetradecanoylphorbol Acetate	55-58	transferrin	Homo sapiens	131-142
1657956-4	1991	12-O-Tetradecanoylphorbol-13-acetate (TPA), a distinct tumor promoter and protein kinase C activator, also induces serine/threonine phosphorylation of the EGF receptor and is known to modulate receptor functions.	Tetradecanoylphorbol Acetate	0-36	epidermal growth factor receptor	Homo sapiens	155-167
1657956-4	1991	12-O-Tetradecanoylphorbol-13-acetate (TPA), a distinct tumor promoter and protein kinase C activator, also induces serine/threonine phosphorylation of the EGF receptor and is known to modulate receptor functions.	Tetradecanoylphorbol Acetate	38-41	epidermal growth factor receptor	Homo sapiens	155-167
1657956-5	1991	Comparison of okadaic acid and TPA influences on the EGF receptor show significant differences.	Tetradecanoylphorbol Acetate	31-34	epidermal growth factor receptor	Homo sapiens	53-65
1718584-4	1991	12-O-Tetradecanoylphorbol-13-acetate (TPA)-dependent activation of the Na+/H+ antiporter was used to determine whether the enzyme is also affected in intact cells.	Tetradecanoylphorbol Acetate	0-36	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	71-88
1667243-3	1991	Incubation of PMN with RAc or RA (1-100 microM) caused a dose-dependent inhibition (upto 90%) in O2- production and chemiluminescence induced by phorbol myristate acetate (PMA), N-formyl-methionyl-leucyl-phenylanaline (fMLP), opsonized zymosan or ionophore A23187.	Tetradecanoylphorbol Acetate	172-175	formyl peptide receptor 1	Homo sapiens	219-223
1718584-4	1991	12-O-Tetradecanoylphorbol-13-acetate (TPA)-dependent activation of the Na+/H+ antiporter was used to determine whether the enzyme is also affected in intact cells.	Tetradecanoylphorbol Acetate	38-41	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	71-88
1933858-10	1991	The findings reported here are compatible with the proposal that TGF-beta mediates some effects of 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	99-135	transforming growth factor beta 1	Homo sapiens	65-73
1726053-9	1991	Smooth muscle cells treated with phorbol 12-myristate 13-acetate or certain combinations of polypeptide growth factors also express increased levels of HBGF-1 and HBGF-2 transcripts.	Tetradecanoylphorbol Acetate	33-64	fibroblast growth factor 1	Homo sapiens	152-158
1726053-9	1991	Smooth muscle cells treated with phorbol 12-myristate 13-acetate or certain combinations of polypeptide growth factors also express increased levels of HBGF-1 and HBGF-2 transcripts.	Tetradecanoylphorbol Acetate	33-64	fibroblast growth factor 2	Homo sapiens	163-169
1814434-6	1991	Treatment of U-937 cells with TPA resulted in a rapid translocation of protein kinase C (PKC) from the cytosol to cell membrane fractions within 2-8 min.	Tetradecanoylphorbol Acetate	30-33	proline rich transmembrane protein 2	Homo sapiens	71-87
1814434-6	1991	Treatment of U-937 cells with TPA resulted in a rapid translocation of protein kinase C (PKC) from the cytosol to cell membrane fractions within 2-8 min.	Tetradecanoylphorbol Acetate	30-33	proline rich transmembrane protein 2	Homo sapiens	89-92
1814434-9	1991	Activation of PKC has been implicated in the regulation of certain immediate early response genes, and in the present studies, TPA rapidly induced c-fos and c-jun gene expression.	Tetradecanoylphorbol Acetate	127-130	proline rich transmembrane protein 2	Homo sapiens	14-17
1814434-11	1991	Staurosporine, a nonspecific inhibitor of PKC, partially blocked TPA-induced adherence and growth inhibition and concomitantly prevented TPA-induced c-fos and c-jun gene expression.	Tetradecanoylphorbol Acetate	65-68	proline rich transmembrane protein 2	Homo sapiens	42-45
1940364-2	1991	After stimulation with Con A and phorbol ester (PMA), normal bovine PBMC exhibited a 3.5-fold induction of pim-1 mRNA within 4 h of stimulation.	Tetradecanoylphorbol Acetate	48-51	Pim-1 proto-oncogene, serine/threonine kinase	Bos taurus	107-112
1940364-5	1991	Typically, stimulation with Con A and PMA together acted synergistically resulting in a greatly increased amount of pim-1 mRNA induction compared to stimulation with either Con A or PMA alone.	Tetradecanoylphorbol Acetate	38-41	Pim-1 proto-oncogene, serine/threonine kinase	Bos taurus	116-121
1940364-5	1991	Typically, stimulation with Con A and PMA together acted synergistically resulting in a greatly increased amount of pim-1 mRNA induction compared to stimulation with either Con A or PMA alone.	Tetradecanoylphorbol Acetate	182-185	Pim-1 proto-oncogene, serine/threonine kinase	Bos taurus	116-121
1935958-5	1991	Retinoic acid induced a time-dependent increase of the t-PA mRNA, with a maximum at 8 h and returning to normal at 24 h. The protein kinase inhibitor H7 decreased the t-PA antigen induced by both retinoic acid and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	214-245	plasminogen activator, tissue type	Homo sapiens	55-59
1935784-7	1991	The stimulation of PRL release by KCl, the calcium ionophore A23187, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate was higher in the presence of PP cells than in cultures of AP cells alone, although the magnitude of this effect was lower than that seen with PRL secretagogues.	Tetradecanoylphorbol Acetate	91-127	prolactin	Rattus norvegicus	19-22
1935784-8	1991	The concomitant application of A23187 and 12-O-tetradecanoylphorbol-13-acetate resulted in an increased response in both types of culture and a greater relative effect of PP cells on the evoked PRL release.	Tetradecanoylphorbol Acetate	42-78	prolactin	Rattus norvegicus	194-197
1935958-5	1991	Retinoic acid induced a time-dependent increase of the t-PA mRNA, with a maximum at 8 h and returning to normal at 24 h. The protein kinase inhibitor H7 decreased the t-PA antigen induced by both retinoic acid and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	214-245	plasminogen activator, tissue type	Homo sapiens	167-171
1655978-2	1991	In previous studies we found that NGF production is up-regulated by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum, down-regulated by corticosterone, and unaffected by dibutyryl-cyclic AMP (db-cyclic AMP) in fibroblasts.	Tetradecanoylphorbol Acetate	68-104	nerve growth factor	Homo sapiens	34-37
1655906-1	1991	The phorbol ester PMA efficiently inhibits the in vitro IFN-alpha and -beta responses in human blood monocytes induced by Sendai virus and in natural IFN-producing cells induced by glutaraldehyde-fixed herpes simplex virus-infected human amnion (WISH) cells.	Tetradecanoylphorbol Acetate	18-21	interferon alpha 1	Homo sapiens	56-75
1655906-4	1991	The synthetic diacylglycerol 1-oleoyl-2-acetylglycerol has the same effects as PMA, and the protein kinase inhibitor staurosporine prevents the PMA-mediated inhibition of IFN-alpha/beta expression.	Tetradecanoylphorbol Acetate	79-82	interferon alpha 1	Homo sapiens	171-180
1655906-4	1991	The synthetic diacylglycerol 1-oleoyl-2-acetylglycerol has the same effects as PMA, and the protein kinase inhibitor staurosporine prevents the PMA-mediated inhibition of IFN-alpha/beta expression.	Tetradecanoylphorbol Acetate	144-147	interferon alpha 1	Homo sapiens	171-180
1660914-3	1991	The induction of C5aR by the synergistic actions of 1,25(OH)2D and cAMP, however, can be augmented as much as 180% by the addition of PMA.	Tetradecanoylphorbol Acetate	134-137	complement C5a receptor 1	Homo sapiens	17-21
1937775-14	1991	Finally, T. pallidum directly stimulated IL-2 synthesis when coincubated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	78-103	interleukin-2	Oryctolagus cuniculus	41-45
1655978-2	1991	In previous studies we found that NGF production is up-regulated by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum, down-regulated by corticosterone, and unaffected by dibutyryl-cyclic AMP (db-cyclic AMP) in fibroblasts.	Tetradecanoylphorbol Acetate	106-109	nerve growth factor	Homo sapiens	34-37
1655978-4	1991	TPA and serum together stimulated NGF production 10-fold more than either agent alone.	Tetradecanoylphorbol Acetate	0-3	nerve growth factor	Homo sapiens	34-37
1655978-7	1991	Forskolin and db-cyclic AMP prevented NGF mRNA induction by TPA and serum without changing basal levels.	Tetradecanoylphorbol Acetate	60-63	nerve growth factor	Homo sapiens	38-41
1659379-2	1991	Short-term treatment of mesangial cells with phorbol 12-myristate 13-acetate (PMA) decreases angiotensin II-induced InsP3 formation, but potentiates hormone-stimulated arachidonic acid release and prostaglandin (PG) E2 synthesis.	Tetradecanoylphorbol Acetate	45-76	angiotensinogen	Rattus norvegicus	93-107
1655978-8	1991	TPA induced c-fos and junB mRNAs transiently and preceding NGF mRNA induction but c-jun mRNA remained undetectable.	Tetradecanoylphorbol Acetate	0-3	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	22-26
1655978-8	1991	TPA induced c-fos and junB mRNAs transiently and preceding NGF mRNA induction but c-jun mRNA remained undetectable.	Tetradecanoylphorbol Acetate	0-3	nerve growth factor	Homo sapiens	59-62
1655978-10	1991	Thus, TPA induction of NGF mRNA is modulated differentially by corticosterone and cyclic AMP.	Tetradecanoylphorbol Acetate	6-9	nerve growth factor	Homo sapiens	23-26
1661797-4	1991	Treatment with purified human monocyte interleukin-1 beta, partially purified lapine, synovial IL-1 or phorbol myristate acetate strongly induced the synthesis of all these enzymes.	Tetradecanoylphorbol Acetate	103-128	interleukin 1 beta	Homo sapiens	39-57
1719968-5	1991	Phorbol 12-myristate 13-acetate, a potent inducer of the differentiation of U937 cells, caused a 12.5-fold increase in VPF mRNA levels at 24 hours, coinciding with the differentiation of these monocyte-like cells into macrophage-like cells.	Tetradecanoylphorbol Acetate	0-31	vascular endothelial growth factor A	Homo sapiens	119-122
1659382-8	1991	Down-regulation of protein kinase C (PKC), by pre-treatment with phorbol 12-myristate 13-acetate, abolished both [3H]choline and [3H]PtdBut formation, suggesting that PLD-catalysed PtdCho hydrolysis may be dependent on PKC activation, supporting its dependence on prior PtdIns(4,5)P2 hydrolysis.	Tetradecanoylphorbol Acetate	65-96	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	167-170
1832583-10	1991	The DN thymocytes from young lpr or MRL-(+/+) mice demonstrated strong and similar proliferative responsiveness to stimulation with PMA + calcium ionophore or PMA + IL-2, or to immobilized mAb directed against the TCRs (CD3, alpha beta and gamma delta).	Tetradecanoylphorbol Acetate	132-135	Fas (TNF receptor superfamily member 6)	Mus musculus	29-32
1832999-5	1991	Receptor-bound 125I Hu-recombinant IFN-gamma was rapidly internalized and degraded when the temperature was increased from 4 degrees C to 37 degrees C. The half-life of this receptor was about 7 hours, and pretreatment of cells with IFN-gamma or phorbol myristate acetate had very little effect on the surface receptor number and no detectable effect on IFN-gamma receptor messenger RNA (mRNA) expression.	Tetradecanoylphorbol Acetate	246-271	interferon gamma	Homo sapiens	35-44
1659379-2	1991	Short-term treatment of mesangial cells with phorbol 12-myristate 13-acetate (PMA) decreases angiotensin II-induced InsP3 formation, but potentiates hormone-stimulated arachidonic acid release and prostaglandin (PG) E2 synthesis.	Tetradecanoylphorbol Acetate	78-81	angiotensinogen	Rattus norvegicus	93-107
1832999-5	1991	Receptor-bound 125I Hu-recombinant IFN-gamma was rapidly internalized and degraded when the temperature was increased from 4 degrees C to 37 degrees C. The half-life of this receptor was about 7 hours, and pretreatment of cells with IFN-gamma or phorbol myristate acetate had very little effect on the surface receptor number and no detectable effect on IFN-gamma receptor messenger RNA (mRNA) expression.	Tetradecanoylphorbol Acetate	246-271	interferon gamma	Homo sapiens	233-242
1832999-5	1991	Receptor-bound 125I Hu-recombinant IFN-gamma was rapidly internalized and degraded when the temperature was increased from 4 degrees C to 37 degrees C. The half-life of this receptor was about 7 hours, and pretreatment of cells with IFN-gamma or phorbol myristate acetate had very little effect on the surface receptor number and no detectable effect on IFN-gamma receptor messenger RNA (mRNA) expression.	Tetradecanoylphorbol Acetate	246-271	interferon gamma	Homo sapiens	233-242
1930148-11	1991	Furthermore, phorbol 12-myristate 13-acetate blocked the HDL3-induced rise in [Ca2+]i.	Tetradecanoylphorbol Acetate	13-44	HDL3	Homo sapiens	57-61
1913689-3	1991	Treatment of DEL cells with 33 nM 12-O-tetradecanoylphorbol-13-acetate for 6-24 h resulted in cell surface attachment (up to 80%), decrease in dividing ability, enhancement of nitro blue tetrazolium reducing capacity (from 8 to 42%), occurrence of a limited immunodependent phagocytosis, and transient increase in expression of tumor necrosis factor alpha gene and in production of tumor necrosis factor alpha protein, whereas tumor necrosis factor beta remained undetectable.	Tetradecanoylphorbol Acetate	34-70	tumor necrosis factor	Homo sapiens	328-355
1913689-3	1991	Treatment of DEL cells with 33 nM 12-O-tetradecanoylphorbol-13-acetate for 6-24 h resulted in cell surface attachment (up to 80%), decrease in dividing ability, enhancement of nitro blue tetrazolium reducing capacity (from 8 to 42%), occurrence of a limited immunodependent phagocytosis, and transient increase in expression of tumor necrosis factor alpha gene and in production of tumor necrosis factor alpha protein, whereas tumor necrosis factor beta remained undetectable.	Tetradecanoylphorbol Acetate	34-70	tumor necrosis factor	Homo sapiens	382-409
1656787-3	1991	Pretreatment of endothelial monolayers with tumor necrosis factor-alpha (TNF-alpha; 200 or 1,000 U/ml) further enhanced the increase in permeability after stimulation of nl-PMN with PMA.	Tetradecanoylphorbol Acetate	182-185	tumor necrosis factor	Homo sapiens	44-71
1656787-3	1991	Pretreatment of endothelial monolayers with tumor necrosis factor-alpha (TNF-alpha; 200 or 1,000 U/ml) further enhanced the increase in permeability after stimulation of nl-PMN with PMA.	Tetradecanoylphorbol Acetate	182-185	tumor necrosis factor	Homo sapiens	73-82
1928448-4	1991	12-O-tetradecanoylphorbol-13-acetate (TPA), which stimulates PC secretion and activates protein kinase C, did not increase [Ca2+]i. Pretreatment of type II cells with the calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibited the PC secretion induced by ATP and TPA and blocked the increase in PI turnover caused by ATP.	Tetradecanoylphorbol Acetate	38-41	calmodulin 1	Homo sapiens	171-181
1656468-4	1991	Furthermore, when transfected CV-1 cells were treated with phorbol 12-myristate 13-acetate, a PKC activator, phosphorylation of wild-type hVDR was enhanced, whereas that of the Ser-51 mutant hVDR was unaffected.	Tetradecanoylphorbol Acetate	59-90	proline rich transmembrane protein 2	Homo sapiens	94-97
1680862-6	1991	Clones expressing two of the three mutant precursors displayed the same stimulation of SS-14 secretion by exogenously administered cAMP and TPA as cells expressing wild-type rPPSS, indicating that targeting specifically to the secretory pathway, or pathways, responsive to cAMP and TPA was not disrupted.	Tetradecanoylphorbol Acetate	140-143	somatostatin	Rattus norvegicus	87-92
1832087-10	1991	The lytic activity of both TNFs was found to be receptor-dependent in that tumor cells, whose TNF binding sites were "down-regulated" by TPA, were rendered resistant to lysis by both membrane-associated and soluble TNFs.	Tetradecanoylphorbol Acetate	137-140	tumor necrosis factor	Mus musculus	27-30
1911215-14	1991	These observations are consistent with the hypothesis that the inhibitory effect of TPA on MCF-7 cells may be partly due to autocrine inhibition by TGF-beta 1.	Tetradecanoylphorbol Acetate	84-87	transforming growth factor beta 1	Homo sapiens	148-158
1911215-7	1991	Rather than preventing transcription of these oestrogen responsive genes, TPA alone increased pNR2 and pNR100 levels in MCF-7 cells and the combined effect of oestradiol and TPA had a marked synergistic effect in increasing the transcript levels of these genes.	Tetradecanoylphorbol Acetate	74-77	trefoil factor 1	Homo sapiens	94-98
1911215-10	1991	An alternative possibility examined was that the growth inhibitory effect of TPA on MCF-7 cells might be due to stimulation of TGF-beta 1, acting as an autocrine inhibitory growth factor.	Tetradecanoylphorbol Acetate	77-80	transforming growth factor beta 1	Homo sapiens	127-137
1911215-12	1991	The combined effect of TPA and oestradiol further increased TGF-beta 1 mRNA above the levels seen with TPA alone.	Tetradecanoylphorbol Acetate	23-26	transforming growth factor beta 1	Homo sapiens	60-70
1911215-12	1991	The combined effect of TPA and oestradiol further increased TGF-beta 1 mRNA above the levels seen with TPA alone.	Tetradecanoylphorbol Acetate	103-106	transforming growth factor beta 1	Homo sapiens	60-70
1654270-3	1991	Following the stimulation by TPA or EGF, the expression of c-jun was increased and the expression of jun D was faintly increased.	Tetradecanoylphorbol Acetate	29-32	Jun proto-oncogene, AP-1 transcription factor subunit	Canis lupus familiaris	59-64
1934258-1	1991	Previous work from our laboratory showed that tumor promoters such as phorbol ester (TPA) stimulated the release of fibronectin (FN) from the surface of several cell types in culture, and that this stimulation was counteracted by retinoic acid.	Tetradecanoylphorbol Acetate	85-88	fibronectin 1	Homo sapiens	116-127
1934258-1	1991	Previous work from our laboratory showed that tumor promoters such as phorbol ester (TPA) stimulated the release of fibronectin (FN) from the surface of several cell types in culture, and that this stimulation was counteracted by retinoic acid.	Tetradecanoylphorbol Acetate	85-88	fibronectin 1	Homo sapiens	129-131
1655395-8	1991	12-O-Tetradecanolylphorbol 13-acetate (TPA), a stimulator of PKC was indeed able to increase intracellular cAMP; this effect was not additive with that of AII.	Tetradecanoylphorbol Acetate	39-42	angiotensinogen	Rattus norvegicus	155-158
1654270-8	1991	Similarly, the TPA or EGF stimulation of c-jun expression was also inhibited by TSH or forskolin, as in fibroblasts in which cyclic-AMP inhibits proliferation.	Tetradecanoylphorbol Acetate	15-18	Jun proto-oncogene, AP-1 transcription factor subunit	Canis lupus familiaris	41-46
1655396-8	1991	12-O-Tetradecanoyl phorbol-13-acetate, an active phorbol ester protein kinase C regulator and inducer of TGF-beta 1 mRNA in many cells, increases TGF-beta 1 mRNA accumulation in JEG-3 cells with a similar time course as cAMP analogs but to a lesser extent.	Tetradecanoylphorbol Acetate	0-37	transforming growth factor beta 1	Homo sapiens	105-115
1655385-8	1991	Depleting the cells of PKC by exposing them to PMA (1 microM) for 3 h caused a marked reduction in control and ANG II-stimulated Na+ influx and control pK (7.09 to 6.85, P less than 0.05).	Tetradecanoylphorbol Acetate	47-50	angiotensinogen	Homo sapiens	111-117
1655396-8	1991	12-O-Tetradecanoyl phorbol-13-acetate, an active phorbol ester protein kinase C regulator and inducer of TGF-beta 1 mRNA in many cells, increases TGF-beta 1 mRNA accumulation in JEG-3 cells with a similar time course as cAMP analogs but to a lesser extent.	Tetradecanoylphorbol Acetate	0-37	transforming growth factor beta 1	Homo sapiens	146-156
1655396-10	1991	Cycloheximide, an inhibitor of protein synthesis, prevents the effect of CT and 12-O-tetradecanoyl phorbol-13-acetate on TGF-beta 1 mRNA expression in JEG-3 cells, suggesting that a protein mediator may be involved in the transduction of their effects.	Tetradecanoylphorbol Acetate	80-117	transforming growth factor beta 1	Homo sapiens	121-131
1757110-6	1991	Work in progress will examine the role of TPA and cAMP response element-binding proteins in regulating gene expression in Lsh congenic mice.	Tetradecanoylphorbol Acetate	42-45	helicase, lymphoid specific	Mus musculus	122-125
1757492-3	1991	A low level of MMP-3 activity was released from the cells (0.12 +/- 0.02 unit per 10(6) cells per 48 h; 1 unit degrades 1 microgram of reduced, carboxymethylated transferrin min-1 at 37 degrees C), but following stimulation by phorbol myristate acetate (PMA) a mean 4.4-fold increase in MMP-3 production was observed (to 0.53 +/- 0.13 unit per 10(6) cells per 48 h).	Tetradecanoylphorbol Acetate	227-252	matrix metallopeptidase 3	Homo sapiens	15-20
1661739-10	1991	Together with the results obtained with phorbol myristate acetate, these data suggest that protein kinase C may play a role in the upregulation of IL-1 beta expression in normal skin fibroblasts.	Tetradecanoylphorbol Acetate	40-65	interleukin 1 beta	Homo sapiens	147-156
1757492-3	1991	A low level of MMP-3 activity was released from the cells (0.12 +/- 0.02 unit per 10(6) cells per 48 h; 1 unit degrades 1 microgram of reduced, carboxymethylated transferrin min-1 at 37 degrees C), but following stimulation by phorbol myristate acetate (PMA) a mean 4.4-fold increase in MMP-3 production was observed (to 0.53 +/- 0.13 unit per 10(6) cells per 48 h).	Tetradecanoylphorbol Acetate	254-257	matrix metallopeptidase 3	Homo sapiens	15-20
1665832-2	1991	In the present study, 12-O-tetradecanoylphorbol 13-acetate (TPA) could cause a dose-dependent expression of LH receptors in the presence of insulin, but not in the absence of insulin, as measured by binding of 125I-deglycosylated human choriogonadotropin (DGhCG).	Tetradecanoylphorbol Acetate	22-58	insulin	Homo sapiens	140-147
1919362-1	1991	Human T-cell cultures infected with human T-lymphotropic virus type I (HTLV-I) and interleukin-2 (IL-2)-dependent for their continuous growth were treated with N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) and then maintained in the medium containing phorbol 12-myristate 13-acetate (TPA).	Tetradecanoylphorbol Acetate	249-280	interleukin 2	Homo sapiens	98-102
1919362-1	1991	Human T-cell cultures infected with human T-lymphotropic virus type I (HTLV-I) and interleukin-2 (IL-2)-dependent for their continuous growth were treated with N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) and then maintained in the medium containing phorbol 12-myristate 13-acetate (TPA).	Tetradecanoylphorbol Acetate	282-285	interleukin 2	Homo sapiens	98-102
1939344-8	1991	When fusion of the L6 cells is inhibited with either a high serum concentration or TGF-beta or TPA, the nucleolar staining by anticalreticulin antibodies is diminished, although the presence of calreticulin in the endoplasmic reticulum remains unchanged.	Tetradecanoylphorbol Acetate	95-98	calreticulin	Homo sapiens	130-142
1797949-1	1991	A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (ac-LDL) receptors.	Tetradecanoylphorbol Acetate	58-83	GLI family zinc finger 2	Homo sapiens	29-34
1797949-1	1991	A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (ac-LDL) receptors.	Tetradecanoylphorbol Acetate	58-83	interleukin 1 beta	Homo sapiens	182-200
1797949-1	1991	A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (ac-LDL) receptors.	Tetradecanoylphorbol Acetate	85-88	GLI family zinc finger 2	Homo sapiens	29-34
1797949-1	1991	A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (ac-LDL) receptors.	Tetradecanoylphorbol Acetate	85-88	interleukin 1 beta	Homo sapiens	182-200
1768743-3	1991	However, treatment of these cells with phorbol myristate acetate (PMA) resulted in the expression of IL-1 beta mRNA.	Tetradecanoylphorbol Acetate	39-64	interleukin 1 beta	Homo sapiens	101-110
1768743-3	1991	However, treatment of these cells with phorbol myristate acetate (PMA) resulted in the expression of IL-1 beta mRNA.	Tetradecanoylphorbol Acetate	66-69	interleukin 1 beta	Homo sapiens	101-110
1768743-4	1991	Likewise, treatment of PBM with phorbol dibutyrate (PdBu), phorbol diacetate (PDA), or mezerein, which, similar to PMA, were able to induce the translocation of protein kinase C (PKc) to the monocyte plasma membrane, resulted in predominantly IL-1 beta mRNA expression.	Tetradecanoylphorbol Acetate	115-118	proline rich transmembrane protein 2	Homo sapiens	161-177
1768743-6	1991	Following 18 h pretreatment with PMA to downregulate PKc activity, LPS was capable of inducing the expression of both forms of IL-1 mRNA, demonstrating that at least part of the response of PBM to LPS is PKc independent.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	53-56
1723143-3	1991	We have previously demonstrated that these cells express both TGF alpha and its receptor [the epidermal growth factor (EGF) receptor] and that expression can be stimulated by phorbol ester (TPA) and EGF.	Tetradecanoylphorbol Acetate	190-193	transforming growth factor alpha	Bos taurus	62-71
1723143-3	1991	We have previously demonstrated that these cells express both TGF alpha and its receptor [the epidermal growth factor (EGF) receptor] and that expression can be stimulated by phorbol ester (TPA) and EGF.	Tetradecanoylphorbol Acetate	190-193	epidermal growth factor receptor	Bos taurus	94-133
1768743-6	1991	Following 18 h pretreatment with PMA to downregulate PKc activity, LPS was capable of inducing the expression of both forms of IL-1 mRNA, demonstrating that at least part of the response of PBM to LPS is PKc independent.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	204-207
1665832-2	1991	In the present study, 12-O-tetradecanoylphorbol 13-acetate (TPA) could cause a dose-dependent expression of LH receptors in the presence of insulin, but not in the absence of insulin, as measured by binding of 125I-deglycosylated human choriogonadotropin (DGhCG).	Tetradecanoylphorbol Acetate	60-63	insulin	Homo sapiens	140-147
1665832-3	1991	The synergistic action of TPA with insulin was achieved at 1 nM and 10 mIU/ml, respectively.	Tetradecanoylphorbol Acetate	26-29	insulin	Homo sapiens	35-42
1665832-6	1991	In addition, insulin modulated the inhibitory effect of TPA in FSH-induced LH receptor expression, indicating a peculiar action of insulin in the receptor expression.	Tetradecanoylphorbol Acetate	56-59	insulin	Homo sapiens	13-20
1665832-6	1991	In addition, insulin modulated the inhibitory effect of TPA in FSH-induced LH receptor expression, indicating a peculiar action of insulin in the receptor expression.	Tetradecanoylphorbol Acetate	56-59	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	75-86
1665832-6	1991	In addition, insulin modulated the inhibitory effect of TPA in FSH-induced LH receptor expression, indicating a peculiar action of insulin in the receptor expression.	Tetradecanoylphorbol Acetate	56-59	insulin	Homo sapiens	131-138
1665832-8	1991	It was shown by Scatchard analysis of LH receptors and kinetic studies of hCG-stimulated cAMP formation that the synergistic action of TPA with insulin led to expression of functional LH receptors coupled with the adenylate cyclase system in cultured granulosa cells.	Tetradecanoylphorbol Acetate	135-138	insulin	Homo sapiens	144-151
1679947-4	1991	The enhancing effect of lithium on IL-2 production showed some differences from that of tetradecanoylphorbol acetate (TPA) in the following aspects: (i) TPA could reverse the inhibitory effect of anti-CD2 monoclonal antibody on IL-2 production, whereas lithium could not; and (ii) lithium was unable to synergistically induce IL-2 production with anti-CD3 monoclonal antibody as TPA did.	Tetradecanoylphorbol Acetate	153-156	interleukin 2	Homo sapiens	35-39
1679947-4	1991	The enhancing effect of lithium on IL-2 production showed some differences from that of tetradecanoylphorbol acetate (TPA) in the following aspects: (i) TPA could reverse the inhibitory effect of anti-CD2 monoclonal antibody on IL-2 production, whereas lithium could not; and (ii) lithium was unable to synergistically induce IL-2 production with anti-CD3 monoclonal antibody as TPA did.	Tetradecanoylphorbol Acetate	153-156	interleukin 2	Homo sapiens	228-232
1718026-5	1991	By stimulation with phytohaemagglutinin (PHA) plus phorbol myristate acetate (PMA), three of the seven helper-type clones produced interleukin 2 (IL-2) in addition to IL-4.	Tetradecanoylphorbol Acetate	51-76	interleukin 2	Homo sapiens	131-144
1718026-5	1991	By stimulation with phytohaemagglutinin (PHA) plus phorbol myristate acetate (PMA), three of the seven helper-type clones produced interleukin 2 (IL-2) in addition to IL-4.	Tetradecanoylphorbol Acetate	51-76	interleukin 2	Homo sapiens	146-150
1718026-5	1991	By stimulation with phytohaemagglutinin (PHA) plus phorbol myristate acetate (PMA), three of the seven helper-type clones produced interleukin 2 (IL-2) in addition to IL-4.	Tetradecanoylphorbol Acetate	78-81	interleukin 2	Homo sapiens	131-144
1718026-5	1991	By stimulation with phytohaemagglutinin (PHA) plus phorbol myristate acetate (PMA), three of the seven helper-type clones produced interleukin 2 (IL-2) in addition to IL-4.	Tetradecanoylphorbol Acetate	78-81	interleukin 2	Homo sapiens	146-150
1679947-4	1991	The enhancing effect of lithium on IL-2 production showed some differences from that of tetradecanoylphorbol acetate (TPA) in the following aspects: (i) TPA could reverse the inhibitory effect of anti-CD2 monoclonal antibody on IL-2 production, whereas lithium could not; and (ii) lithium was unable to synergistically induce IL-2 production with anti-CD3 monoclonal antibody as TPA did.	Tetradecanoylphorbol Acetate	153-156	interleukin 2	Homo sapiens	228-232
1718026-5	1991	By stimulation with phytohaemagglutinin (PHA) plus phorbol myristate acetate (PMA), three of the seven helper-type clones produced interleukin 2 (IL-2) in addition to IL-4.	Tetradecanoylphorbol Acetate	78-81	interleukin 4	Homo sapiens	167-171
1679947-4	1991	The enhancing effect of lithium on IL-2 production showed some differences from that of tetradecanoylphorbol acetate (TPA) in the following aspects: (i) TPA could reverse the inhibitory effect of anti-CD2 monoclonal antibody on IL-2 production, whereas lithium could not; and (ii) lithium was unable to synergistically induce IL-2 production with anti-CD3 monoclonal antibody as TPA did.	Tetradecanoylphorbol Acetate	153-156	interleukin 2	Homo sapiens	35-39
1679947-4	1991	The enhancing effect of lithium on IL-2 production showed some differences from that of tetradecanoylphorbol acetate (TPA) in the following aspects: (i) TPA could reverse the inhibitory effect of anti-CD2 monoclonal antibody on IL-2 production, whereas lithium could not; and (ii) lithium was unable to synergistically induce IL-2 production with anti-CD3 monoclonal antibody as TPA did.	Tetradecanoylphorbol Acetate	153-156	interleukin 2	Homo sapiens	228-232
1679947-4	1991	The enhancing effect of lithium on IL-2 production showed some differences from that of tetradecanoylphorbol acetate (TPA) in the following aspects: (i) TPA could reverse the inhibitory effect of anti-CD2 monoclonal antibody on IL-2 production, whereas lithium could not; and (ii) lithium was unable to synergistically induce IL-2 production with anti-CD3 monoclonal antibody as TPA did.	Tetradecanoylphorbol Acetate	153-156	interleukin 2	Homo sapiens	228-232
1656952-4	1991	Treatment with phorbol 12-myristate 13-acetate (PMA) for 24 h dose-dependently inhibited Epo formation, thus suggesting that down-regulation of PKC might be responsible for this inhibition.	Tetradecanoylphorbol Acetate	15-46	erythropoietin	Homo sapiens	89-92
1796389-4	1991	A positive correlation was demonstrated between vWF:Ag/FVIII:C ratio and tPA:antigen levels suggesting that both tPA and vWF:Ag could be considered as early indicators of a possible micro angiopathy occurring in preeclampsia.	Tetradecanoylphorbol Acetate	73-76	von Willebrand factor	Homo sapiens	48-51
1656952-4	1991	Treatment with phorbol 12-myristate 13-acetate (PMA) for 24 h dose-dependently inhibited Epo formation, thus suggesting that down-regulation of PKC might be responsible for this inhibition.	Tetradecanoylphorbol Acetate	15-46	protein kinase C alpha	Homo sapiens	144-147
1656952-4	1991	Treatment with phorbol 12-myristate 13-acetate (PMA) for 24 h dose-dependently inhibited Epo formation, thus suggesting that down-regulation of PKC might be responsible for this inhibition.	Tetradecanoylphorbol Acetate	48-51	erythropoietin	Homo sapiens	89-92
1656952-4	1991	Treatment with phorbol 12-myristate 13-acetate (PMA) for 24 h dose-dependently inhibited Epo formation, thus suggesting that down-regulation of PKC might be responsible for this inhibition.	Tetradecanoylphorbol Acetate	48-51	protein kinase C alpha	Homo sapiens	144-147
1656952-5	1991	Immunoblotting experiments showed that incubation of HepG2 cells with PMA for 24 h resulted in a selective and almost complete down-regulation of PKC-alpha.	Tetradecanoylphorbol Acetate	70-73	protein kinase C alpha	Homo sapiens	146-155
1716287-7	1991	A specific PKC agonist, PMA, which bypasses the CD3 receptor, could, however, activate MAP-2K in HPB-ALL cells.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 3	Homo sapiens	87-93
1917923-0	1991	Post-transcriptional destabilization of estrogen receptor mRNA in MCF-7 cells by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	81-117	estrogen receptor 1	Homo sapiens	40-57
1917923-1	1991	The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the regulation of the estrogen receptor (ER) was investigated in this study.	Tetradecanoylphorbol Acetate	14-50	estrogen receptor 1	Homo sapiens	82-99
1917923-1	1991	The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the regulation of the estrogen receptor (ER) was investigated in this study.	Tetradecanoylphorbol Acetate	14-50	estrogen receptor 1	Homo sapiens	101-103
1917923-1	1991	The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the regulation of the estrogen receptor (ER) was investigated in this study.	Tetradecanoylphorbol Acetate	52-55	estrogen receptor 1	Homo sapiens	82-99
1917923-1	1991	The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the regulation of the estrogen receptor (ER) was investigated in this study.	Tetradecanoylphorbol Acetate	52-55	estrogen receptor 1	Homo sapiens	101-103
1917923-3	1991	By 24 h the receptor protein declined by about 80% from a level of approximately 236 fmol of ER/mg of protein in control cells to 50 fmol of ER/mg of protein in cells treated with TPA.	Tetradecanoylphorbol Acetate	180-183	estrogen receptor 1	Homo sapiens	141-143
1917923-5	1991	After removal of TPA, the level of ER returned to control values.	Tetradecanoylphorbol Acetate	17-20	estrogen receptor 1	Homo sapiens	35-37
1917923-7	1991	The effects of TPA on ER expression appear to be mediated by activation of protein kinase C as H-7, an inhibitor of protein kinase C, blocks these effects.	Tetradecanoylphorbol Acetate	15-18	estrogen receptor 1	Homo sapiens	22-24
1917923-8	1991	In addition to the effect on ER protein, TPA treatment also resulted in a decrease in the steady-state level of ER mRNA as determined by a RNase protection assay.	Tetradecanoylphorbol Acetate	41-44	estrogen receptor 1	Homo sapiens	29-31
1917923-8	1991	In addition to the effect on ER protein, TPA treatment also resulted in a decrease in the steady-state level of ER mRNA as determined by a RNase protection assay.	Tetradecanoylphorbol Acetate	41-44	estrogen receptor 1	Homo sapiens	112-114
1917923-11	1991	A half-life study demonstrated that TPA decreased ER mRNA half-life by a factor of 6 from approximately 4 h in control cells to 40 min in TPA-treated cells.	Tetradecanoylphorbol Acetate	36-39	estrogen receptor 1	Homo sapiens	50-52
1917923-11	1991	A half-life study demonstrated that TPA decreased ER mRNA half-life by a factor of 6 from approximately 4 h in control cells to 40 min in TPA-treated cells.	Tetradecanoylphorbol Acetate	138-141	estrogen receptor 1	Homo sapiens	50-52
1793019-2	1991	A detailed kinetic analysis of the interaction of NPC 15437 and a homogeneous preparation of PKC-alpha revealed a competitive type of inhibition with respect to activation of the enzyme by both phorbol 12-myristate 13-acetate (PMA) (Ki = 5 +/- 3 microM) and phosphatidylserine (PS) (Ki = 12 +/- 4 microM).	Tetradecanoylphorbol Acetate	194-225	protein kinase C, alpha	Mus musculus	93-102
1909730-6	1991	PMA induced low level of IL-6 production by highly purified PP B cells.	Tetradecanoylphorbol Acetate	0-3	interleukin 6	Mus musculus	25-29
1657043-7	1991	An inhibitor of protein kinase C, H7, or a long-term pretreatment of cells with PMA for 24 h inhibited the effect of ET-1 and PMA on Na+/H+ exchange.	Tetradecanoylphorbol Acetate	80-83	endothelin 1	Rattus norvegicus	117-129
1893379-6	1991	UCN-01 inhibited the down-modulation of epidermal growth factor receptor caused by phorbol 12-myristate 13-acetate in A431 cells at a near 50% inhibitory concentration for cell growth.	Tetradecanoylphorbol Acetate	83-114	epidermal growth factor receptor	Homo sapiens	40-72
1653238-11	1991	Two putative 12-O-tetradecanoyl-phorbol-13-acetate (TPA) response elements, that might serve as binding sites for the transcription factor AP-1 and a consensus sequence of a transforming growth factor beta 1 (TGF-beta 1) inhibitory element were found in the promoter region.	Tetradecanoylphorbol Acetate	13-50	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	139-143
1653238-11	1991	Two putative 12-O-tetradecanoyl-phorbol-13-acetate (TPA) response elements, that might serve as binding sites for the transcription factor AP-1 and a consensus sequence of a transforming growth factor beta 1 (TGF-beta 1) inhibitory element were found in the promoter region.	Tetradecanoylphorbol Acetate	13-50	transforming growth factor beta 1	Homo sapiens	174-207
1653238-11	1991	Two putative 12-O-tetradecanoyl-phorbol-13-acetate (TPA) response elements, that might serve as binding sites for the transcription factor AP-1 and a consensus sequence of a transforming growth factor beta 1 (TGF-beta 1) inhibitory element were found in the promoter region.	Tetradecanoylphorbol Acetate	13-50	transforming growth factor beta 1	Homo sapiens	209-219
1653238-11	1991	Two putative 12-O-tetradecanoyl-phorbol-13-acetate (TPA) response elements, that might serve as binding sites for the transcription factor AP-1 and a consensus sequence of a transforming growth factor beta 1 (TGF-beta 1) inhibitory element were found in the promoter region.	Tetradecanoylphorbol Acetate	52-55	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	139-143
1653238-11	1991	Two putative 12-O-tetradecanoyl-phorbol-13-acetate (TPA) response elements, that might serve as binding sites for the transcription factor AP-1 and a consensus sequence of a transforming growth factor beta 1 (TGF-beta 1) inhibitory element were found in the promoter region.	Tetradecanoylphorbol Acetate	52-55	transforming growth factor beta 1	Homo sapiens	174-207
1653238-11	1991	Two putative 12-O-tetradecanoyl-phorbol-13-acetate (TPA) response elements, that might serve as binding sites for the transcription factor AP-1 and a consensus sequence of a transforming growth factor beta 1 (TGF-beta 1) inhibitory element were found in the promoter region.	Tetradecanoylphorbol Acetate	52-55	transforming growth factor beta 1	Homo sapiens	209-219
1793019-2	1991	A detailed kinetic analysis of the interaction of NPC 15437 and a homogeneous preparation of PKC-alpha revealed a competitive type of inhibition with respect to activation of the enzyme by both phorbol 12-myristate 13-acetate (PMA) (Ki = 5 +/- 3 microM) and phosphatidylserine (PS) (Ki = 12 +/- 4 microM).	Tetradecanoylphorbol Acetate	227-230	protein kinase C, alpha	Mus musculus	93-102
1652310-2	1991	The defect in signal transduction occurred at a point proximal to the generation of IP3 and DAG, since the reduction in FMLP-induced superoxide generation was corrected if the intervening signal transduction steps were bypassed, either by priming with a substimulatory dose (1.62 nmol/L) of phorbol myristate acetate (PMA), by ionophore elevation of cytosolic calcium, or by using a stimulatory dose of PMA (1.62 mumol/L).	Tetradecanoylphorbol Acetate	291-316	formyl peptide receptor 1	Homo sapiens	120-124
1652310-2	1991	The defect in signal transduction occurred at a point proximal to the generation of IP3 and DAG, since the reduction in FMLP-induced superoxide generation was corrected if the intervening signal transduction steps were bypassed, either by priming with a substimulatory dose (1.62 nmol/L) of phorbol myristate acetate (PMA), by ionophore elevation of cytosolic calcium, or by using a stimulatory dose of PMA (1.62 mumol/L).	Tetradecanoylphorbol Acetate	318-321	formyl peptide receptor 1	Homo sapiens	120-124
1652310-2	1991	The defect in signal transduction occurred at a point proximal to the generation of IP3 and DAG, since the reduction in FMLP-induced superoxide generation was corrected if the intervening signal transduction steps were bypassed, either by priming with a substimulatory dose (1.62 nmol/L) of phorbol myristate acetate (PMA), by ionophore elevation of cytosolic calcium, or by using a stimulatory dose of PMA (1.62 mumol/L).	Tetradecanoylphorbol Acetate	403-406	formyl peptide receptor 1	Homo sapiens	120-124
1751774-0	1991	Tumor necrosis factor-alpha, interleukin 1, and phorbol myristate acetate are independent activators of NF-kappa B which differentially activate T cells.	Tetradecanoylphorbol Acetate	48-73	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	104-114
1898344-5	1991	Treatment in vitro with 1 microM-phorbol 12-myristate 13-acetate (PMA) resulted in a similar percentage increase in glucose use by Kupffer cells prepared from either saline- or TNF-treated rats.	Tetradecanoylphorbol Acetate	33-64	tumor necrosis factor	Rattus norvegicus	177-180
1898344-5	1991	Treatment in vitro with 1 microM-phorbol 12-myristate 13-acetate (PMA) resulted in a similar percentage increase in glucose use by Kupffer cells prepared from either saline- or TNF-treated rats.	Tetradecanoylphorbol Acetate	66-69	tumor necrosis factor	Rattus norvegicus	177-180
1651818-8	1991	To study the potential role of PKC in Ang II desensitization, the cells are treated with TPA for 24 hours, which downregulates PKC activity.	Tetradecanoylphorbol Acetate	89-92	angiotensinogen	Homo sapiens	38-44
1932892-8	1991	In all three types of cells, under control as well as under stimulated conditions, a high molecular weight form of PA was demonstrated by the gel overlay technique, most likely a complex of tPA with the PA-inhibitor PAI-1.	Tetradecanoylphorbol Acetate	190-193	serpin family E member 1	Rattus norvegicus	216-221
1831409-1	1991	We investigated the expression of the T cell receptor (TCR)/CD3 complex on a CD4-positive human T cell lymphoma cell line treated with phorbol myristate acetate (PMA) and/or CA2+ ionophore using fluorescence flow cytometry and fluorescence microscopic analysis.	Tetradecanoylphorbol Acetate	135-160	CD4 molecule	Homo sapiens	77-80
1831409-1	1991	We investigated the expression of the T cell receptor (TCR)/CD3 complex on a CD4-positive human T cell lymphoma cell line treated with phorbol myristate acetate (PMA) and/or CA2+ ionophore using fluorescence flow cytometry and fluorescence microscopic analysis.	Tetradecanoylphorbol Acetate	162-165	CD4 molecule	Homo sapiens	77-80
1959503-4	1991	In most experiments, fibronectin proteolysis was suppressed by smoke exposure--an effect that was reversible on treatment with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	127-152	fibronectin 1	Homo sapiens	21-32
1651854-7	1991	Activation of PKC by 12-O-Tetradecanoylphorbol 13-acetate (TPA) inhibited in a time-dependent manner the NE-stimulated production of IPs in young and mature hypothalamic neurons; however, in PKC depleted cells NE-induced IPs formation remained unchanged.	Tetradecanoylphorbol Acetate	21-57	proline rich transmembrane protein 2	Homo sapiens	14-17
1651854-7	1991	Activation of PKC by 12-O-Tetradecanoylphorbol 13-acetate (TPA) inhibited in a time-dependent manner the NE-stimulated production of IPs in young and mature hypothalamic neurons; however, in PKC depleted cells NE-induced IPs formation remained unchanged.	Tetradecanoylphorbol Acetate	59-62	proline rich transmembrane protein 2	Homo sapiens	14-17
1651854-7	1991	Activation of PKC by 12-O-Tetradecanoylphorbol 13-acetate (TPA) inhibited in a time-dependent manner the NE-stimulated production of IPs in young and mature hypothalamic neurons; however, in PKC depleted cells NE-induced IPs formation remained unchanged.	Tetradecanoylphorbol Acetate	59-62	proline rich transmembrane protein 2	Homo sapiens	191-194
1716311-7	1991	Mast cells were also incubated overnight with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to down regulate PKC and the response to goat anti-human IgE was measured.	Tetradecanoylphorbol Acetate	64-100	proline rich transmembrane protein 2	Homo sapiens	124-127
1937565-4	1991	A large number of Fn fragments were revealed by Western immunoblotting of serum-free conditioned medium 4 hr after treatment of CPAE monolayers with PMA.	Tetradecanoylphorbol Acetate	149-152	fibronectin 1	Homo sapiens	18-20
1716311-7	1991	Mast cells were also incubated overnight with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to down regulate PKC and the response to goat anti-human IgE was measured.	Tetradecanoylphorbol Acetate	102-105	proline rich transmembrane protein 2	Homo sapiens	124-127
1861162-5	1991	Induction of VGF mRNA by depolarization and phorbol 12-myristate 13-acetate treatment was greater than by serum stimulation or protein kinase A pathway activation.	Tetradecanoylphorbol Acetate	44-75	VGF nerve growth factor inducible	Rattus norvegicus	13-16
1716311-9	1991	Despite using agents which act by different mechanisms, short-term inhibition with staurosporine and long-term treatment with TPA, we obtained consistent results which suggest that PKC is playing a prorelease role in IgE-mediated signaling.	Tetradecanoylphorbol Acetate	126-129	proline rich transmembrane protein 2	Homo sapiens	181-184
1716311-9	1991	Despite using agents which act by different mechanisms, short-term inhibition with staurosporine and long-term treatment with TPA, we obtained consistent results which suggest that PKC is playing a prorelease role in IgE-mediated signaling.	Tetradecanoylphorbol Acetate	126-129	immunoglobulin heavy constant epsilon	Homo sapiens	217-220
1716311-7	1991	Mast cells were also incubated overnight with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to down regulate PKC and the response to goat anti-human IgE was measured.	Tetradecanoylphorbol Acetate	102-105	immunoglobulin heavy constant epsilon	Homo sapiens	164-167
1716311-8	1991	Prolonged exposure to 100 ng/ml of TPA reduced IgE-mediated histamine release from 28 +/- 6 to 6 +/- 1% in the skin mast cells whereas similar treatment only reduced the response of lung mast cells from 36 +/- 5 to 26 +/- 6%.	Tetradecanoylphorbol Acetate	35-38	immunoglobulin heavy constant epsilon	Homo sapiens	47-50
1652474-4	1991	PMA stimulated phosphorylation of a single major IGF-I receptor phosphoserine peptide which was phosphorylated to a lesser extent after IGF-I.	Tetradecanoylphorbol Acetate	0-3	insulin like growth factor 1	Homo sapiens	49-54
1871966-5	1991	The MN- and, to a lesser extent, IIIB-derived peptides also increased CD4 expression on the cell membrane and differentially inhibited CD4 down-regulation induced by the phorbol ester TPA and/or by the monosialoganglioside GM1; the peptides showing no viral infection enhancement had no such effects.	Tetradecanoylphorbol Acetate	184-187	CD4 molecule	Homo sapiens	135-138
1883381-1	1991	Amphiregulin-associated protein (ARAP) was purified from serum-free conditioned medium of MCF-7, human breast carcinoma cells, treated with 12-0-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	178-181	midkine	Homo sapiens	0-31
1883381-1	1991	Amphiregulin-associated protein (ARAP) was purified from serum-free conditioned medium of MCF-7, human breast carcinoma cells, treated with 12-0-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	178-181	midkine	Homo sapiens	33-37
1872896-7	1991	TPA (12-O-tetradecanoylphorbol-13-acetate) also produced a significant (P less than 0.05) reduction of 32P-Pi uptake, suggesting that protein kinase C is involved in the transduction of ang II effects on intracellular Pi.	Tetradecanoylphorbol Acetate	0-3	angiotensinogen	Rattus norvegicus	186-192
1883854-1	1991	Incubation of endometrial cells with 100 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) for 2, 5, 10 and 30 min decreased cytosolic protein kinase C (PKC) activity to 80%, 68%, 66%, and 72% of the control values, while membrane-associated PKC increased to 116%, 168%, 154% and 134% of the control values, respectively.	Tetradecanoylphorbol Acetate	44-80	proline rich transmembrane protein 2	Homo sapiens	131-147
1883854-1	1991	Incubation of endometrial cells with 100 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) for 2, 5, 10 and 30 min decreased cytosolic protein kinase C (PKC) activity to 80%, 68%, 66%, and 72% of the control values, while membrane-associated PKC increased to 116%, 168%, 154% and 134% of the control values, respectively.	Tetradecanoylphorbol Acetate	44-80	proline rich transmembrane protein 2	Homo sapiens	149-152
1883854-1	1991	Incubation of endometrial cells with 100 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) for 2, 5, 10 and 30 min decreased cytosolic protein kinase C (PKC) activity to 80%, 68%, 66%, and 72% of the control values, while membrane-associated PKC increased to 116%, 168%, 154% and 134% of the control values, respectively.	Tetradecanoylphorbol Acetate	44-80	proline rich transmembrane protein 2	Homo sapiens	238-241
1883854-1	1991	Incubation of endometrial cells with 100 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) for 2, 5, 10 and 30 min decreased cytosolic protein kinase C (PKC) activity to 80%, 68%, 66%, and 72% of the control values, while membrane-associated PKC increased to 116%, 168%, 154% and 134% of the control values, respectively.	Tetradecanoylphorbol Acetate	82-85	proline rich transmembrane protein 2	Homo sapiens	131-147
1883854-1	1991	Incubation of endometrial cells with 100 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) for 2, 5, 10 and 30 min decreased cytosolic protein kinase C (PKC) activity to 80%, 68%, 66%, and 72% of the control values, while membrane-associated PKC increased to 116%, 168%, 154% and 134% of the control values, respectively.	Tetradecanoylphorbol Acetate	82-85	proline rich transmembrane protein 2	Homo sapiens	149-152
1883854-1	1991	Incubation of endometrial cells with 100 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) for 2, 5, 10 and 30 min decreased cytosolic protein kinase C (PKC) activity to 80%, 68%, 66%, and 72% of the control values, while membrane-associated PKC increased to 116%, 168%, 154% and 134% of the control values, respectively.	Tetradecanoylphorbol Acetate	82-85	proline rich transmembrane protein 2	Homo sapiens	238-241
1883854-2	1991	Long-term incubation of cells with TPA resulted in a loss in total PKC activity.	Tetradecanoylphorbol Acetate	35-38	proline rich transmembrane protein 2	Homo sapiens	67-70
1883854-9	1991	The present results indicate that TPA induces an intracellular translocation and down-regulation of PKC.	Tetradecanoylphorbol Acetate	34-37	proline rich transmembrane protein 2	Homo sapiens	100-103
1868448-6	1991	Similarly, p53 levels increased and DNA synthesis decreased during 12-O-tetradecanoylphorbol-13-acetate-induced differentiation of ML-1 myeloblastic leukemia cells.	Tetradecanoylphorbol Acetate	67-103	tumor protein p53	Homo sapiens	11-14
1713584-8	1991	Expression from a luciferase reporter construct containing a 460-nucleotide fragment of the TIS21 promoter is induced by tetradecanoyl phorbol acetate, forskolin, epidermal growth factor, and serum, despite the absence of a consensus serum response element.	Tetradecanoylphorbol Acetate	121-150	BTG anti-proliferation factor 2	Mus musculus	92-97
1872896-7	1991	TPA (12-O-tetradecanoylphorbol-13-acetate) also produced a significant (P less than 0.05) reduction of 32P-Pi uptake, suggesting that protein kinase C is involved in the transduction of ang II effects on intracellular Pi.	Tetradecanoylphorbol Acetate	5-41	angiotensinogen	Rattus norvegicus	186-192
1907306-4	1991	We found that most clones from both the peripheral blood and CSF express IL-1, IL-2, IL-4, IFN-gamma, or TNF-alpha cytokine mRNA after activation with ionomycin and PMA.	Tetradecanoylphorbol Acetate	165-168	tumor necrosis factor	Homo sapiens	105-114
1953275-6	1991	The influence of protein kinase C and that of G proteins on the mitogenesis in cells stimulated by thrombin or AVP was determined by pretreating cells with phorbol 12-myristate, 13-acetate (TPA) and pertussis toxin, respectively.	Tetradecanoylphorbol Acetate	190-193	coagulation factor II	Rattus norvegicus	99-107
1831129-3	1991	In the presence of phytohemagglutinin or anti-T cell receptor monoclonal antibodies and phorbol 12-myristate 13-acetate, the IFN-gamma promoter is activated in human T cells, which can be further enhanced by co-transfection of the tax I or II genes.	Tetradecanoylphorbol Acetate	88-119	interferon gamma	Homo sapiens	125-134
1831130-1	1991	Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens.	Tetradecanoylphorbol Acetate	89-120	interferon gamma	Mus musculus	181-197
1831130-1	1991	Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens.	Tetradecanoylphorbol Acetate	89-120	interferon gamma	Mus musculus	199-208
1831130-1	1991	Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens.	Tetradecanoylphorbol Acetate	122-125	interferon gamma	Mus musculus	181-197
1831130-1	1991	Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens.	Tetradecanoylphorbol Acetate	122-125	interferon gamma	Mus musculus	199-208
1916896-2	1991	In combination with 12-0-tetradecanoylphorbol-13-acetate (TPA), a potent activator of PKC, TNF-alpha caused marked inhibition of the growth of LoVo cells.	Tetradecanoylphorbol Acetate	58-61	proline rich transmembrane protein 2	Homo sapiens	86-89
1916896-2	1991	In combination with 12-0-tetradecanoylphorbol-13-acetate (TPA), a potent activator of PKC, TNF-alpha caused marked inhibition of the growth of LoVo cells.	Tetradecanoylphorbol Acetate	58-61	tumor necrosis factor	Homo sapiens	91-100
1916896-3	1991	Inhibition of PANC-1 cell growth by TNF-alpha was blocked by pretreatment with TPA for 24 hr, along with down-regulation of PKC activity.	Tetradecanoylphorbol Acetate	79-82	tumor necrosis factor	Homo sapiens	36-45
1830601-3	1991	For TCR-alpha beta-bearing CD4+8+ and CD4+8low thymocytes that are actively engaged in positive and negative selection processes, negligible to low levels of IL-2 production and cell proliferation were observed in response to TCR:CD3 triggering or to the combined activation of protein kinase C and calcium mobilization mediated by PMA and ionomycin, respectively.	Tetradecanoylphorbol Acetate	332-335	CD4 molecule	Homo sapiens	27-30
1830601-4	1991	For CD4-8- TCR-alpha beta early thymocytes that have not yet entered the selection process, PMA + ionomycin induced significant cell proliferation but little IL-2 production, in the absence of added IL-1.	Tetradecanoylphorbol Acetate	92-95	CD4 molecule	Homo sapiens	4-7
1830601-4	1991	For CD4-8- TCR-alpha beta early thymocytes that have not yet entered the selection process, PMA + ionomycin induced significant cell proliferation but little IL-2 production, in the absence of added IL-1.	Tetradecanoylphorbol Acetate	92-95	interleukin 2	Homo sapiens	158-162
1830601-10	1991	The lack of anti-TCR-induced IL-2 production by thymus CD4+8- T cells was not due to an intrinsic defect as high levels of IL-2 production was induced by PMA + ionomycin.	Tetradecanoylphorbol Acetate	154-157	interleukin 2	Homo sapiens	123-127
1907307-0	1991	Reversal of defective IL-6 production in lipopolysaccharide-tolerant mice by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	77-102	interleukin 6	Mus musculus	22-26
1663789-8	1991	Treatment of cells with the protein kinase C activator phorbol myristate acetate (PMA) also resulted in the tyrosine phosphorylation of MAP kinase, and again only at 37 degrees C. Tryptic phosphopeptide maps demonstrated that EGF and PMA both induced the phosphorylation of the same peptide on tyrosine and threonine.	Tetradecanoylphorbol Acetate	55-80	regulator of microtubule dynamics 3	Homo sapiens	136-139
1663789-8	1991	Treatment of cells with the protein kinase C activator phorbol myristate acetate (PMA) also resulted in the tyrosine phosphorylation of MAP kinase, and again only at 37 degrees C. Tryptic phosphopeptide maps demonstrated that EGF and PMA both induced the phosphorylation of the same peptide on tyrosine and threonine.	Tetradecanoylphorbol Acetate	82-85	regulator of microtubule dynamics 3	Homo sapiens	136-139
2070568-4	1991	Although stimulation with PMA induced a translocation of PKC from the cytosol to the particulate fraction, translocated PKC activity after 2 nM PMA treatment was decreased in the SLE T cells.	Tetradecanoylphorbol Acetate	26-29	proline rich transmembrane protein 2	Homo sapiens	57-60
2070568-4	1991	Although stimulation with PMA induced a translocation of PKC from the cytosol to the particulate fraction, translocated PKC activity after 2 nM PMA treatment was decreased in the SLE T cells.	Tetradecanoylphorbol Acetate	26-29	proline rich transmembrane protein 2	Homo sapiens	120-123
2070568-4	1991	Although stimulation with PMA induced a translocation of PKC from the cytosol to the particulate fraction, translocated PKC activity after 2 nM PMA treatment was decreased in the SLE T cells.	Tetradecanoylphorbol Acetate	144-147	proline rich transmembrane protein 2	Homo sapiens	120-123
1756233-3	1991	Here we studied the effects of the tumor promoter phorbol ester (TPA), or the calcium ionophore A23187, on the pattern of expression of 2-5 A synthetase isoforms, and found a role of protein kinase C (PKC) in the adjustments of this pattern.	Tetradecanoylphorbol Acetate	65-68	protein kinase C, alpha	Mus musculus	201-204
1756233-6	1991	By contrast long term treatments by TPA resulting in the down regulation of PKC, or employing H7, a specific PKC inhibitor, reduced drastically the induction by IFNs of the 100 kDa enzyme in HeLa or fibroblast cells, without reducing the expression of the other forms.	Tetradecanoylphorbol Acetate	36-39	protein kinase C, alpha	Mus musculus	76-79
1831204-6	1991	These alterations were not blocked by the protein kinase C inhibitor H-7, which did inhibit TPA-induced T cell attachment to fibronectin.	Tetradecanoylphorbol Acetate	92-95	fibronectin 1	Homo sapiens	125-136
1761792-1	1991	T cell growth factors such as interleukin-2 (IL-2) and interleukin-4 (IL-4) act as potent comitogenic factors for purified human T cells in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	156-181	interleukin 2	Homo sapiens	30-43
1761792-1	1991	T cell growth factors such as interleukin-2 (IL-2) and interleukin-4 (IL-4) act as potent comitogenic factors for purified human T cells in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	156-181	interleukin 2	Homo sapiens	45-49
1761792-1	1991	T cell growth factors such as interleukin-2 (IL-2) and interleukin-4 (IL-4) act as potent comitogenic factors for purified human T cells in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	156-181	interleukin 4	Homo sapiens	55-68
1761792-1	1991	T cell growth factors such as interleukin-2 (IL-2) and interleukin-4 (IL-4) act as potent comitogenic factors for purified human T cells in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	156-181	interleukin 4	Homo sapiens	70-74
1761792-1	1991	T cell growth factors such as interleukin-2 (IL-2) and interleukin-4 (IL-4) act as potent comitogenic factors for purified human T cells in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	183-186	interleukin 2	Homo sapiens	30-43
1761792-1	1991	T cell growth factors such as interleukin-2 (IL-2) and interleukin-4 (IL-4) act as potent comitogenic factors for purified human T cells in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	183-186	interleukin 2	Homo sapiens	45-49
1761792-1	1991	T cell growth factors such as interleukin-2 (IL-2) and interleukin-4 (IL-4) act as potent comitogenic factors for purified human T cells in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	183-186	interleukin 4	Homo sapiens	55-68
1761792-1	1991	T cell growth factors such as interleukin-2 (IL-2) and interleukin-4 (IL-4) act as potent comitogenic factors for purified human T cells in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	183-186	interleukin 4	Homo sapiens	70-74
1761792-5	1991	PMA + IL-2 stimulation was more sensitive to the inhibitory effects of gangliosides (I50 = 77.2 microM) than PMA + IL-4 stimulation (I50 = 105.9 microM).	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Homo sapiens	6-10
1829461-7	1991	In contrast to intact cells, purified uPA receptor (isolated from phorbol 12-myristate 13-acetate-stimulated U937 cells) was observed to partially inhibit uPA-catalyzed Plg activation, although activity against low molecular weight substrates was retained.	Tetradecanoylphorbol Acetate	66-97	plasminogen activator, urokinase	Homo sapiens	38-41
1791639-2	1991	Stimulation of protein kinase C (Pk-C) by tumour promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) produces at day 7 in vitro a similar network after only 20 hr.	Tetradecanoylphorbol Acetate	67-103	PKC	Sus scrofa	15-31
1791639-2	1991	Stimulation of protein kinase C (Pk-C) by tumour promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) produces at day 7 in vitro a similar network after only 20 hr.	Tetradecanoylphorbol Acetate	67-103	PKC	Sus scrofa	33-37
1791639-2	1991	Stimulation of protein kinase C (Pk-C) by tumour promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) produces at day 7 in vitro a similar network after only 20 hr.	Tetradecanoylphorbol Acetate	105-108	PKC	Sus scrofa	15-31
1791639-2	1991	Stimulation of protein kinase C (Pk-C) by tumour promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) produces at day 7 in vitro a similar network after only 20 hr.	Tetradecanoylphorbol Acetate	105-108	PKC	Sus scrofa	33-37
1713680-7	1991	Phorbol 12-myristate 13-acetate, a known activator of protein kinase C (PKC), weakly induces NF-kappa B-like activity, ELAM-1 mRNA, and ELAM-1 surface expression in HUVEC.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	54-70
1713680-7	1991	Phorbol 12-myristate 13-acetate, a known activator of protein kinase C (PKC), weakly induces NF-kappa B-like activity, ELAM-1 mRNA, and ELAM-1 surface expression in HUVEC.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	72-75
1713680-7	1991	Phorbol 12-myristate 13-acetate, a known activator of protein kinase C (PKC), weakly induces NF-kappa B-like activity, ELAM-1 mRNA, and ELAM-1 surface expression in HUVEC.	Tetradecanoylphorbol Acetate	0-31	nuclear factor kappa B subunit 1	Homo sapiens	93-103
1713210-5	1991	Treatment of the cells with 4 beta-phorbol 12-myristate 13-acetate resulted in a diminished binding of 125I-EGF to the receptors.	Tetradecanoylphorbol Acetate	28-66	LOC521832	Bos taurus	108-111
1858038-6	1991	We showed that either calcium ionophore (A23187) or phorbol myristate acetate increased CPT gene transcription and that either calcium chelation, protein kinase C inhibition (acridine orange), or chronic exposure to phorbol myristate acetate significantly inhibited IL-1 alpha induction of CPT mRNA.	Tetradecanoylphorbol Acetate	216-241	interleukin 1 alpha	Rattus norvegicus	266-276
1907763-5	1991	Protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA) could partially mimic IFN-gamma effect in inducing class II expression on endothelial cells.	Tetradecanoylphorbol Acetate	33-64	interferon gamma	Homo sapiens	93-102
1907763-5	1991	Protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA) could partially mimic IFN-gamma effect in inducing class II expression on endothelial cells.	Tetradecanoylphorbol Acetate	66-69	interferon gamma	Homo sapiens	93-102
1907763-6	1991	PMA together with another PKC activator arachidonic acid (AA) induced class II expression on endothelial cells as well as IFN-gamma.	Tetradecanoylphorbol Acetate	0-3	interferon gamma	Homo sapiens	122-131
1856209-2	1991	The production of IL-8 is usually not constitutive and can be induced rapidly and abundantly in different cell types by a variety of stimuli such as lipopolysaccharide, interleukin-1, tumor necrosis factor-alpha as well as a tumor promotor phorbol myristate acetate.	Tetradecanoylphorbol Acetate	240-265	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
1855195-1	1991	Specific activators of protein kinase C (PKC), including the phorbol-ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), can reduce the chemosensitivities of a variety of mammalian tumor cell lines and their cytotoxic drug-selected multidrug resistant (MDR) variants to MDR-linked drugs, thus implicating PKC in the MDR phenotype.	Tetradecanoylphorbol Acetate	90-126	proline rich transmembrane protein 2	Homo sapiens	23-39
1855195-1	1991	Specific activators of protein kinase C (PKC), including the phorbol-ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), can reduce the chemosensitivities of a variety of mammalian tumor cell lines and their cytotoxic drug-selected multidrug resistant (MDR) variants to MDR-linked drugs, thus implicating PKC in the MDR phenotype.	Tetradecanoylphorbol Acetate	90-126	proline rich transmembrane protein 2	Homo sapiens	41-44
1855195-1	1991	Specific activators of protein kinase C (PKC), including the phorbol-ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), can reduce the chemosensitivities of a variety of mammalian tumor cell lines and their cytotoxic drug-selected multidrug resistant (MDR) variants to MDR-linked drugs, thus implicating PKC in the MDR phenotype.	Tetradecanoylphorbol Acetate	90-126	proline rich transmembrane protein 2	Homo sapiens	318-321
1855195-1	1991	Specific activators of protein kinase C (PKC), including the phorbol-ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), can reduce the chemosensitivities of a variety of mammalian tumor cell lines and their cytotoxic drug-selected multidrug resistant (MDR) variants to MDR-linked drugs, thus implicating PKC in the MDR phenotype.	Tetradecanoylphorbol Acetate	128-131	proline rich transmembrane protein 2	Homo sapiens	23-39
1855195-1	1991	Specific activators of protein kinase C (PKC), including the phorbol-ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), can reduce the chemosensitivities of a variety of mammalian tumor cell lines and their cytotoxic drug-selected multidrug resistant (MDR) variants to MDR-linked drugs, thus implicating PKC in the MDR phenotype.	Tetradecanoylphorbol Acetate	128-131	proline rich transmembrane protein 2	Homo sapiens	41-44
1855195-1	1991	Specific activators of protein kinase C (PKC), including the phorbol-ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), can reduce the chemosensitivities of a variety of mammalian tumor cell lines and their cytotoxic drug-selected multidrug resistant (MDR) variants to MDR-linked drugs, thus implicating PKC in the MDR phenotype.	Tetradecanoylphorbol Acetate	128-131	proline rich transmembrane protein 2	Homo sapiens	318-321
1855195-5	1991	We report that the kinetics of TPA-induced downregulation of PKC activity differ markedly in parental and MDR UV-2237M cells, providing evidence that the overexpression of phorbol-ester responsive PKC in adriamycin-selected MDR UV-2237M-ADRR cells results, at least in part, from a reduced rate of PKC degradation in the cells.	Tetradecanoylphorbol Acetate	31-34	proline rich transmembrane protein 2	Homo sapiens	61-64
1829461-7	1991	In contrast to intact cells, purified uPA receptor (isolated from phorbol 12-myristate 13-acetate-stimulated U937 cells) was observed to partially inhibit uPA-catalyzed Plg activation, although activity against low molecular weight substrates was retained.	Tetradecanoylphorbol Acetate	66-97	plasminogen activator, urokinase	Homo sapiens	155-158
1855195-5	1991	We report that the kinetics of TPA-induced downregulation of PKC activity differ markedly in parental and MDR UV-2237M cells, providing evidence that the overexpression of phorbol-ester responsive PKC in adriamycin-selected MDR UV-2237M-ADRR cells results, at least in part, from a reduced rate of PKC degradation in the cells.	Tetradecanoylphorbol Acetate	31-34	proline rich transmembrane protein 2	Homo sapiens	197-200
1855195-5	1991	We report that the kinetics of TPA-induced downregulation of PKC activity differ markedly in parental and MDR UV-2237M cells, providing evidence that the overexpression of phorbol-ester responsive PKC in adriamycin-selected MDR UV-2237M-ADRR cells results, at least in part, from a reduced rate of PKC degradation in the cells.	Tetradecanoylphorbol Acetate	31-34	proline rich transmembrane protein 2	Homo sapiens	197-200
1854615-17	1991	Contemporaneous measurement of serum CEA levels only slightly increases sensitivity and positive predictive value of TPA-CA15-3 combination.	Tetradecanoylphorbol Acetate	117-120	CEA cell adhesion molecule 3	Homo sapiens	37-40
1830456-8	1991	Phorbol 12-myristate 13-acetate (PMA), 10(-6) and 10(-7) M, also decreased the amplitude of the Ca2+ transients similar to ANG II.	Tetradecanoylphorbol Acetate	0-31	angiotensinogen	Rattus norvegicus	123-129
1888027-1	1991	A protein kinase C (PKC)-selective peptide substrate was used to develop a method for measuring PKC activity directly and quantitatively in isolated cell membranes without prior detergent extraction and reconstitution of the enzyme with phosphatidylserine and TPA in the presence of excess Ca2+.	Tetradecanoylphorbol Acetate	260-263	proline rich transmembrane protein 2	Homo sapiens	2-18
1888027-1	1991	A protein kinase C (PKC)-selective peptide substrate was used to develop a method for measuring PKC activity directly and quantitatively in isolated cell membranes without prior detergent extraction and reconstitution of the enzyme with phosphatidylserine and TPA in the presence of excess Ca2+.	Tetradecanoylphorbol Acetate	260-263	proline rich transmembrane protein 2	Homo sapiens	20-23
1888027-1	1991	A protein kinase C (PKC)-selective peptide substrate was used to develop a method for measuring PKC activity directly and quantitatively in isolated cell membranes without prior detergent extraction and reconstitution of the enzyme with phosphatidylserine and TPA in the presence of excess Ca2+.	Tetradecanoylphorbol Acetate	260-263	proline rich transmembrane protein 2	Homo sapiens	96-99
1648385-5	1991	Similarly, the more stable protein kinase C activator 4 beta-phorbol-12-myristate-13-acetate (PMA) caused about a 10-fold increase in t-PA antigen levels.	Tetradecanoylphorbol Acetate	56-92	plasminogen activator, tissue type	Homo sapiens	134-138
1648385-5	1991	Similarly, the more stable protein kinase C activator 4 beta-phorbol-12-myristate-13-acetate (PMA) caused about a 10-fold increase in t-PA antigen levels.	Tetradecanoylphorbol Acetate	94-97	plasminogen activator, tissue type	Homo sapiens	134-138
1648385-12	1991	The induction of t-PA mRNA by PMA was dependent on protein synthesis and was preceded by a strong transient increase in c-jun and c-fos mRNA levels; the induction of c-fos but not of c-jun was potentiated by forskolin.	Tetradecanoylphorbol Acetate	30-33	plasminogen activator, tissue type	Homo sapiens	17-21
2055193-1	1991	Treatment of MCF-7 cells, a human mammary carcinoma cell line, with phorbol ester [12-O-tetradecanoylphorbol-13-acetate (TPA)] or calcium ionophore (A23187) was associated with striking effects on levels of estrogen receptor (ER) mRNA, specific binding of 17 beta-[3H]estradiol [( 3H]E2), and immunoreactive ER.	Tetradecanoylphorbol Acetate	83-119	estrogen receptor 1	Homo sapiens	207-224
1709824-7	1991	Although phorbol myristate acetate (PMA) greatly enhanced PHA-stimulated IL2 production by Jurkat cells.	Tetradecanoylphorbol Acetate	9-34	interleukin 2	Homo sapiens	73-76
1709824-7	1991	Although phorbol myristate acetate (PMA) greatly enhanced PHA-stimulated IL2 production by Jurkat cells.	Tetradecanoylphorbol Acetate	36-39	interleukin 2	Homo sapiens	73-76
1675604-6	1991	This mutant also functions in vivo as a trans-acting dominant negative regulator: the transcriptional inducibility of the HIV long terminal repeat (which contains two potential NF-kappa B binding sites) by phorbol ester (PMA) is inhibited when it is co-transfected into CD4+ T cells with the delta SP mutant.	Tetradecanoylphorbol Acetate	221-224	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	177-187
1715317-2	1991	FK-506 and CsA were also potent inhibitors of A23187/PMA-stimulated IL-2 production by Jurkat and HuT-78 cells but had no effect on the response of mouse CTLL cells to IL-2.	Tetradecanoylphorbol Acetate	53-56	interleukin 2	Homo sapiens	68-72
1911538-3	1991	When the human IgM-producing cell line SSK41 is stimulated with interleukin 4 (IL-4) in the presence of phorbol myristate acetate (PMA) or Staphylococcus aureus Cowan I, expression of germline C gamma 3 transcripts was specifically augmented within 4 h. Upstream DNA fragments flanking the I gamma 3 exon were fused with a reporter gene and tested for IL-4-induced promoter/enhancer activity by transfection of SSK41 cells.	Tetradecanoylphorbol Acetate	131-134	interleukin 4	Homo sapiens	64-77
2056282-1	1991	The minimal region of the human tumor necrosis factor alpha (TNF-alpha) gene promoter necessary for its transcriptional induction by phorbol esters (PMA) in human T and B lymphocyte cell lines has been localized between -52 and +89 nucleotides (nt) relative to the gene"s transcriptional start site.	Tetradecanoylphorbol Acetate	149-152	tumor necrosis factor	Homo sapiens	32-59
2056282-1	1991	The minimal region of the human tumor necrosis factor alpha (TNF-alpha) gene promoter necessary for its transcriptional induction by phorbol esters (PMA) in human T and B lymphocyte cell lines has been localized between -52 and +89 nucleotides (nt) relative to the gene"s transcriptional start site.	Tetradecanoylphorbol Acetate	149-152	tumor necrosis factor	Homo sapiens	61-70
1646841-2	1991	Both protein kinase C-activating phorbol esters, e.g., PMA, and LPS induce IL-1 beta expression in these cells.	Tetradecanoylphorbol Acetate	55-58	interleukin 1 beta	Homo sapiens	75-84
1832571-3	1991	IL2 secretion induced by phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187, which bypasses the breakdown of inositol phospholipids induced by the ligand-receptor interaction, was still suppressed by LO inhibitors which implies that these drugs also have an inhibitory effect on other target(s).	Tetradecanoylphorbol Acetate	25-56	interleukin 2	Homo sapiens	0-3
1832571-3	1991	IL2 secretion induced by phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187, which bypasses the breakdown of inositol phospholipids induced by the ligand-receptor interaction, was still suppressed by LO inhibitors which implies that these drugs also have an inhibitory effect on other target(s).	Tetradecanoylphorbol Acetate	58-61	interleukin 2	Homo sapiens	0-3
1648223-5	1991	However, the v-myc-associated block of phorbol 12-myristate 13-acetate-, 1 alpha,25-dihydroxycholecalciferol-, and retinoic acid-induced differentiation retinoic acid-induced differentiation can be overcome by adding interferon gamma as a costimulatory factor.	Tetradecanoylphorbol Acetate	39-70	interferon gamma	Homo sapiens	217-233
1724574-1	1991	Flow cytofluorometric protocols (FACScan) are described for the rapid and quantitative real-time analysis of binding of FITC-pro-u-PA to cell surface receptors (u-PAR) on living, resting, and also on PMA-stimulated human monocytic U937 cells.	Tetradecanoylphorbol Acetate	200-203	plasminogen activator, urokinase	Homo sapiens	129-133
1647984-1	1991	alpha-Thrombin, phorbol esters (PMA) and 1,2-diacylglycerol (DAG), three activators of the amiloride-sensitive Na+/H+ exchange in human platelets, rapidly increase the intracellular pH and the level of phosphorylation of the Na+/H+ exchange protein (NHE1).	Tetradecanoylphorbol Acetate	32-35	solute carrier family 9 member A1	Homo sapiens	250-254
1711045-8	1991	The promoter region also contains several potential binding sites for the transcription factors AP-1 and AP-2; consistent with the presence of these sites, Northern blot analysis demonstrated that the level of VEGF transcripts is elevated in cultured vascular smooth muscle cells after treatment with the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	319-356	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	96-100
1711045-8	1991	The promoter region also contains several potential binding sites for the transcription factors AP-1 and AP-2; consistent with the presence of these sites, Northern blot analysis demonstrated that the level of VEGF transcripts is elevated in cultured vascular smooth muscle cells after treatment with the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	319-356	vascular endothelial growth factor A	Homo sapiens	210-214
1905804-1	1991	Transcription of the human urokinase type plasminogen activator (uPA) gene in HeLa cells is induced by phorbol myristate acetate (PMA), interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha).	Tetradecanoylphorbol Acetate	103-128	plasminogen activator, urokinase	Homo sapiens	27-63
1905804-1	1991	Transcription of the human urokinase type plasminogen activator (uPA) gene in HeLa cells is induced by phorbol myristate acetate (PMA), interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha).	Tetradecanoylphorbol Acetate	103-128	plasminogen activator, urokinase	Homo sapiens	65-68
1905804-1	1991	Transcription of the human urokinase type plasminogen activator (uPA) gene in HeLa cells is induced by phorbol myristate acetate (PMA), interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha).	Tetradecanoylphorbol Acetate	130-133	plasminogen activator, urokinase	Homo sapiens	27-63
1905804-1	1991	Transcription of the human urokinase type plasminogen activator (uPA) gene in HeLa cells is induced by phorbol myristate acetate (PMA), interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha).	Tetradecanoylphorbol Acetate	130-133	plasminogen activator, urokinase	Homo sapiens	65-68
2062642-1	1991	cyr61 is an immediate early gene that is transcriptionally activated in 3T3 fibroblasts by serum, platelet-derived growth factor, fibroblast growth factor, and the tumor promoter TPA with kinetics similar to the induction of c-fos.	Tetradecanoylphorbol Acetate	179-182	cellular communication network factor 1	Mus musculus	0-5
1889509-7	1991	Addition of PMA at a concentration of 100 ng/ml into the medium caused an increase in the cellular and medium levels of hCG alpha, hCG beta and hCG shortly (3h) after the exposure to PMA.	Tetradecanoylphorbol Acetate	12-15	chromogranin A	Homo sapiens	120-129
1889509-7	1991	Addition of PMA at a concentration of 100 ng/ml into the medium caused an increase in the cellular and medium levels of hCG alpha, hCG beta and hCG shortly (3h) after the exposure to PMA.	Tetradecanoylphorbol Acetate	183-186	chromogranin A	Homo sapiens	120-129
1905924-6	1991	Stimulation of THP1 cells for 2-4 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) activated cytosolic and membrane-bound phospholipase A2.	Tetradecanoylphorbol Acetate	59-90	GLI family zinc finger 2	Homo sapiens	15-19
1905924-6	1991	Stimulation of THP1 cells for 2-4 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) activated cytosolic and membrane-bound phospholipase A2.	Tetradecanoylphorbol Acetate	59-90	phospholipase A2 group IB	Homo sapiens	136-152
1905924-6	1991	Stimulation of THP1 cells for 2-4 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) activated cytosolic and membrane-bound phospholipase A2.	Tetradecanoylphorbol Acetate	92-95	GLI family zinc finger 2	Homo sapiens	15-19
1905924-6	1991	Stimulation of THP1 cells for 2-4 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) activated cytosolic and membrane-bound phospholipase A2.	Tetradecanoylphorbol Acetate	92-95	phospholipase A2 group IB	Homo sapiens	136-152
1904797-3	1991	Tumour promoters phorbol-12-myristate-13-acetate (PMA) and mezerein produced an increase in poly ADPRT activity in both normal and CML lymphocytes, but the increase was more marked in the case of normals.	Tetradecanoylphorbol Acetate	17-48	poly(ADP-ribose) polymerase 1	Homo sapiens	97-102
1904797-3	1991	Tumour promoters phorbol-12-myristate-13-acetate (PMA) and mezerein produced an increase in poly ADPRT activity in both normal and CML lymphocytes, but the increase was more marked in the case of normals.	Tetradecanoylphorbol Acetate	50-53	poly(ADP-ribose) polymerase 1	Homo sapiens	97-102
2052609-2	1991	When Jurkat cells or their Nef-2-expressing transformants are treated with phorbol 12-myristate 13-acetate (PMA) plus either phytohemagglutinin (PHA) or antibodies against CD3 epsilon, T-cell receptor beta chain, or CD2, there is a prompt increase in interleukin 2 (IL-2) mRNA and intracellular calcium and in the IL-2 receptor alpha chain on the cell surface.	Tetradecanoylphorbol Acetate	75-106	S100 calcium binding protein B	Homo sapiens	27-30
2052609-6	1991	Nef-1-expressing cells can produce IL-2 mRNA in response to a combination of PMA and ionomycin, although much less efficiently than the parental Jurkat cells or Nef-2-expressing cells.	Tetradecanoylphorbol Acetate	77-80	S100 calcium binding protein B	Homo sapiens	0-3
2052609-6	1991	Nef-1-expressing cells can produce IL-2 mRNA in response to a combination of PMA and ionomycin, although much less efficiently than the parental Jurkat cells or Nef-2-expressing cells.	Tetradecanoylphorbol Acetate	77-80	interleukin 2	Homo sapiens	35-39
1710933-6	1991	Brief exposure of EC to PMA strongly inhibits thrombin-induced [Ca2+]i rise, acetyltransferase activation and PAF production, suggesting that, in addition to the positive forward action, PKC provides a negative feedback control over membrane signalling pathways involved in the thrombin effect on EC.	Tetradecanoylphorbol Acetate	24-27	coagulation factor II, thrombin	Homo sapiens	46-54
1710933-6	1991	Brief exposure of EC to PMA strongly inhibits thrombin-induced [Ca2+]i rise, acetyltransferase activation and PAF production, suggesting that, in addition to the positive forward action, PKC provides a negative feedback control over membrane signalling pathways involved in the thrombin effect on EC.	Tetradecanoylphorbol Acetate	24-27	coagulation factor II, thrombin	Homo sapiens	278-286
2037585-7	1991	Short pretreatment of the cells with phorbol 12-myristate 13-acetate (PMA) abolished the BK-induced breakdown of phosphoinositides, but did not affect the second-phase DGc level.	Tetradecanoylphorbol Acetate	37-68	kininogen 1	Homo sapiens	89-91
2037585-7	1991	Short pretreatment of the cells with phorbol 12-myristate 13-acetate (PMA) abolished the BK-induced breakdown of phosphoinositides, but did not affect the second-phase DGc level.	Tetradecanoylphorbol Acetate	70-73	kininogen 1	Homo sapiens	89-91
2037585-10	1991	In contrast, two inhibitors of PKC, staurosporin and 1-O-hexadecyl-2-O-methylglycerol, inhibited both BK- and PMA-induced DGc formation at 30 min, leaving the rapid response towards BK unaffected.	Tetradecanoylphorbol Acetate	110-113	kininogen 1	Homo sapiens	182-184
2037586-12	1991	The protein kinase C (PKC) inhibitors staurosporin and 1-O-hexadecyl-2-O-methylglycerol inhibited BK- and PMA-induced activation of PLD.	Tetradecanoylphorbol Acetate	106-109	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	132-135
1711295-4	1991	Attachment of phorbol 12-myristate, 13-acetate (PMA)-stimulated W256 cells to endothelial monolayers was increased 1.8 +/- 0.1-fold and damage (3H-2-deoxyglucose release from labeled endothelium) 1.4 +/- 0.1-fold after 4-hour pretreatment of the endothelium with 10 ng/ml recombinant human interleukin-1 alpha (rIL-1 alpha).	Tetradecanoylphorbol Acetate	48-51	interleukin 1 alpha	Rattus norvegicus	311-322
1715967-6	1991	Application of 8-bromo-cAMP (cAMP), N-methyl-D-aspartate (NMDA), substance P, muscimol, A23187 and VIP to electrically active cultures resulted in a 2- to 3-fold increase in mRNAVIP, while phorbol myristate 13-acetate (PMA) and 8-bromo-cGMP (cGMP) had no effect.	Tetradecanoylphorbol Acetate	219-222	vasoactive intestinal polypeptide	Mus musculus	99-102
1715967-7	1991	In contrast, electrically inactive cultures exhibited a 3 to 4-fold increase in mRNAVIP after treatment with PMA, cAMP and VIP, while NMDA, substance P, muscimol, A23187 and cGMP produced no increases.	Tetradecanoylphorbol Acetate	109-112	vasoactive intestinal polypeptide	Mus musculus	84-87
1909183-4	1991	Compared with the parental and control cells, only a modest but substantially sustained (2- to 3-fold) increase in the accumulation of uPA as well as c-fos mRNAs were observed by TPA in these cells.	Tetradecanoylphorbol Acetate	179-182	plasminogen activator, urokinase	Sus scrofa	135-138
1645255-4	1991	UMR-106 cells treated with protein kinase C (PK-C) activating phorbol ester, phorbol 12-myristate 13-acetate (PMA, 10(-6) M) for 6 h also induced desensitization manifested by a loss of rPTH-stimulated cAMP accumulation to 50% of that in the control cells.	Tetradecanoylphorbol Acetate	77-108	parathyroid hormone	Rattus norvegicus	186-190
1645255-4	1991	UMR-106 cells treated with protein kinase C (PK-C) activating phorbol ester, phorbol 12-myristate 13-acetate (PMA, 10(-6) M) for 6 h also induced desensitization manifested by a loss of rPTH-stimulated cAMP accumulation to 50% of that in the control cells.	Tetradecanoylphorbol Acetate	110-113	parathyroid hormone	Rattus norvegicus	186-190
2036955-1	1991	We have reported previously that anterior pituitary cells released interleukin-6 (IL-6) and that this release was stimulated by lipopolysaccharide (LPS), phorbol myristate acetate (PMA), or agents that increased intracellular cAMP concentrations.	Tetradecanoylphorbol Acetate	154-179	interleukin 6	Rattus norvegicus	67-80
2036955-1	1991	We have reported previously that anterior pituitary cells released interleukin-6 (IL-6) and that this release was stimulated by lipopolysaccharide (LPS), phorbol myristate acetate (PMA), or agents that increased intracellular cAMP concentrations.	Tetradecanoylphorbol Acetate	154-179	interleukin 6	Rattus norvegicus	82-86
2036955-1	1991	We have reported previously that anterior pituitary cells released interleukin-6 (IL-6) and that this release was stimulated by lipopolysaccharide (LPS), phorbol myristate acetate (PMA), or agents that increased intracellular cAMP concentrations.	Tetradecanoylphorbol Acetate	181-184	interleukin 6	Rattus norvegicus	67-80
2036955-1	1991	We have reported previously that anterior pituitary cells released interleukin-6 (IL-6) and that this release was stimulated by lipopolysaccharide (LPS), phorbol myristate acetate (PMA), or agents that increased intracellular cAMP concentrations.	Tetradecanoylphorbol Acetate	181-184	interleukin 6	Rattus norvegicus	82-86
1649023-11	1991	Further support for this hypothesis was obtained after interferon-gamma treatment of human monocytes which led to an augmented PMA-inducible release of active oxygen radicals, but was not paralleled by growth restriction of L. monocytogenes.	Tetradecanoylphorbol Acetate	127-130	interferon gamma	Homo sapiens	55-71
2055193-2	1991	TPA (10(-7) M) caused a time-dependent reduction of ER mRNA which was below the level of detection after 9 h. Similar effects of TPA appeared at levels of specific binding of [3H]E2 as well as immunoreactive ER.	Tetradecanoylphorbol Acetate	0-3	estrogen receptor 1	Homo sapiens	52-54
2055193-2	1991	TPA (10(-7) M) caused a time-dependent reduction of ER mRNA which was below the level of detection after 9 h. Similar effects of TPA appeared at levels of specific binding of [3H]E2 as well as immunoreactive ER.	Tetradecanoylphorbol Acetate	0-3	estrogen receptor 1	Homo sapiens	208-210
2055193-2	1991	TPA (10(-7) M) caused a time-dependent reduction of ER mRNA which was below the level of detection after 9 h. Similar effects of TPA appeared at levels of specific binding of [3H]E2 as well as immunoreactive ER.	Tetradecanoylphorbol Acetate	129-132	estrogen receptor 1	Homo sapiens	52-54
2055193-2	1991	TPA (10(-7) M) caused a time-dependent reduction of ER mRNA which was below the level of detection after 9 h. Similar effects of TPA appeared at levels of specific binding of [3H]E2 as well as immunoreactive ER.	Tetradecanoylphorbol Acetate	129-132	estrogen receptor 1	Homo sapiens	208-210
2055193-4	1991	Incubation of MCF-7 cells with increasing concentrations of TPA (10(-11)-10(-7) M) was associated with biphasic effects on ER mRNA and proteins.	Tetradecanoylphorbol Acetate	60-63	estrogen receptor 1	Homo sapiens	123-125
2055193-1	1991	Treatment of MCF-7 cells, a human mammary carcinoma cell line, with phorbol ester [12-O-tetradecanoylphorbol-13-acetate (TPA)] or calcium ionophore (A23187) was associated with striking effects on levels of estrogen receptor (ER) mRNA, specific binding of 17 beta-[3H]estradiol [( 3H]E2), and immunoreactive ER.	Tetradecanoylphorbol Acetate	83-119	estrogen receptor 1	Homo sapiens	226-228
2055193-1	1991	Treatment of MCF-7 cells, a human mammary carcinoma cell line, with phorbol ester [12-O-tetradecanoylphorbol-13-acetate (TPA)] or calcium ionophore (A23187) was associated with striking effects on levels of estrogen receptor (ER) mRNA, specific binding of 17 beta-[3H]estradiol [( 3H]E2), and immunoreactive ER.	Tetradecanoylphorbol Acetate	83-119	estrogen receptor 1	Homo sapiens	308-310
1709663-6	1991	Furthermore, formation of 1-O-[3H]alkyl-2-acyl-phosphatidylethanol, produced by phospholipase D in the presence of ethanol by a transphosphatidylation reaction, was significantly inhibited by pretreatment of cells with PGE2 and IBMX in FMLP- but not PMA-stimulated neutrophils.	Tetradecanoylphorbol Acetate	250-253	formyl peptide receptor 1	Homo sapiens	236-240
1827816-6	1991	In addition, immunoprecipitation analysis of PMA/ionomycin-treated T cell lysates detected only minor levels of cellular IL-8 Ag thereby suggesting that in T cells, the production of IL-8 was inhibited at the posttranscriptional level.	Tetradecanoylphorbol Acetate	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
1715761-0	1991	Negative regulation of interleukin-2 production in primary lymphocytes by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	74-110	interleukin 2	Homo sapiens	23-36
1903411-3	1991	In the present report we have studied various agents that, like TPA, act as partial or complete mitogens for G0 PBL and have determined their effect on phosphorylation of prosolin and on DNA synthesis in rapidly proliferating (IL-2-dependent) human PBL.	Tetradecanoylphorbol Acetate	64-67	interleukin 2	Homo sapiens	227-231
2051767-4	1991	At 0.01-1.0 microgram/ml, PMA, a potent stimulant of PKC, exerted profound stimulatory effects on secondary MLC supernatant (2 degrees SN)-induced proliferation of allosensitized T cells (132-200% increase, P less than 0.01).	Tetradecanoylphorbol Acetate	26-29	proline rich transmembrane protein 2	Homo sapiens	53-56
1715761-9	1991	Under conditions of TPA treatment in which protein kinase C was chronically reduced in T lymphocytes, IL-2 production was greatly depressed as were the level of IL-2 mRNA and [3H]thymidine incorporation.	Tetradecanoylphorbol Acetate	20-23	interleukin 2	Homo sapiens	102-106
1712443-2	1991	Chronic exposure of human Burkitt lymphoma and mouse M1 myeloblastic cell lines to phorbol myristate acetate (PMA), reduced by more than 90% the PKC protein levels and enzymatic activity in cell extracts.	Tetradecanoylphorbol Acetate	83-108	proline rich transmembrane protein 2	Homo sapiens	145-148
1715761-9	1991	Under conditions of TPA treatment in which protein kinase C was chronically reduced in T lymphocytes, IL-2 production was greatly depressed as were the level of IL-2 mRNA and [3H]thymidine incorporation.	Tetradecanoylphorbol Acetate	20-23	interleukin 2	Homo sapiens	161-165
1745043-3	1991	Maximal TNF-alpha production by HPBAC was observed in 4 to 8 hr after incubation when these cells were cultured for 24 hr with 10 micrograms/ml lipopolysaccharide (LPS), 10 ng/ml 12-o-tetradecanoyl-phorbol-13-acetate (TPA) and 10(-5) M indomethacin (INDM).	Tetradecanoylphorbol Acetate	179-216	tumor necrosis factor	Homo sapiens	8-17
1745043-3	1991	Maximal TNF-alpha production by HPBAC was observed in 4 to 8 hr after incubation when these cells were cultured for 24 hr with 10 micrograms/ml lipopolysaccharide (LPS), 10 ng/ml 12-o-tetradecanoyl-phorbol-13-acetate (TPA) and 10(-5) M indomethacin (INDM).	Tetradecanoylphorbol Acetate	218-221	tumor necrosis factor	Homo sapiens	8-17
1717834-6	1991	Long term treatment with the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) reduced the VP mRNA level by 75%.	Tetradecanoylphorbol Acetate	43-80	arginine vasopressin	Homo sapiens	99-101
1717834-6	1991	Long term treatment with the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) reduced the VP mRNA level by 75%.	Tetradecanoylphorbol Acetate	82-85	arginine vasopressin	Homo sapiens	99-101
1717834-7	1991	The TPA-suppressed VP mRNA levels could be up-regulated about 6-fold by simultaneous treatment with 8-bromo-cAMP.	Tetradecanoylphorbol Acetate	4-7	arginine vasopressin	Homo sapiens	19-21
1712443-2	1991	Chronic exposure of human Burkitt lymphoma and mouse M1 myeloblastic cell lines to phorbol myristate acetate (PMA), reduced by more than 90% the PKC protein levels and enzymatic activity in cell extracts.	Tetradecanoylphorbol Acetate	110-113	proline rich transmembrane protein 2	Homo sapiens	145-148
1712443-5	1991	The same prolonged treatment of M1 cells with PMA did not interfere with the ability of another cytokine, transforming growth factor beta (TGF-beta), to induce the normal type of G0/G1 arrest further supporting the specificity of the effect towards IFN responses.	Tetradecanoylphorbol Acetate	46-49	interferon alpha 1	Homo sapiens	249-252
1708255-9	1991	The inactivation of bradykinin by intact neutrophils was decreased by phorbol 12-myristate 13-acetate, probably due to down-regulation by endocytosis of the neutral endopeptidase on the plasma membrane.	Tetradecanoylphorbol Acetate	70-101	kininogen 1	Homo sapiens	20-30
2048200-6	1991	Depletion of protein kinase C (PKC) activity from cells by pretreatment of Daudi cells with phorbol.12-myristate 13-acetate (PMA) abolished the G0/G1 arrest induced by both CsA and IFN-alpha.	Tetradecanoylphorbol Acetate	125-128	interferon alpha 1	Homo sapiens	181-190
1645527-7	1991	Inhibitors of PKC partially blocked the induction of NMPs by CAF and completely suppressed the potentiating effect of PMA.	Tetradecanoylphorbol Acetate	118-121	proline rich transmembrane protein 2	Homo sapiens	14-17
1645542-3	1991	Phorbol-12-myristate-13-acetate induction resulted in inhibition of myeloperoxidase expression within 24 hrs.	Tetradecanoylphorbol Acetate	0-31	myeloperoxidase	Homo sapiens	68-83
1903932-8	1991	The protein kinase C activator phorbol myristate acetate also stimulated a large release of choline after a 5 min lag, which was unaffected by the Ca2+ ionophore ionomycin, but was additive with AngII stimulation.	Tetradecanoylphorbol Acetate	31-56	angiotensinogen	Homo sapiens	195-200
1709735-8	1991	Phorbol 12-myristate 13-acetate also stimulated protein tyrosine phosphorylation, but some of the modulated proteins were different than those phosphorylated by LPS.	Tetradecanoylphorbol Acetate	0-31	toll-like receptor 4	Mus musculus	161-164
1908735-12	1991	Demethoxyviridin also inhibited PLD activation induced by sodium fluoride or phorbol myristate acetate (PMA) but the concentrations required were 100 times those needed to block fMet-Leu-Phe-stimulated PLD.	Tetradecanoylphorbol Acetate	77-102	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	32-35
1908735-12	1991	Demethoxyviridin also inhibited PLD activation induced by sodium fluoride or phorbol myristate acetate (PMA) but the concentrations required were 100 times those needed to block fMet-Leu-Phe-stimulated PLD.	Tetradecanoylphorbol Acetate	104-107	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	32-35
1828344-4	1991	IL1R phosphorylation was only detected in cells pretreated with phorbol 12-myristate 13-acetate (PMA) and occurred solely on phosphothreonine.	Tetradecanoylphorbol Acetate	64-95	interleukin 1 receptor type 1	Homo sapiens	0-4
1828344-4	1991	IL1R phosphorylation was only detected in cells pretreated with phorbol 12-myristate 13-acetate (PMA) and occurred solely on phosphothreonine.	Tetradecanoylphorbol Acetate	97-100	interleukin 1 receptor type 1	Homo sapiens	0-4
1828294-1	1991	A short region of the human proenkephalin promoter has been shown previously to mediate transcriptional regulation in response to activation of the cAMP, TPA, and Ca+ + dependent intracellular signalling pathways.	Tetradecanoylphorbol Acetate	154-157	proenkephalin	Homo sapiens	28-41
1828153-7	1991	Ang II (10(9) - 10(-8) M) and a protein kinase C activator, phorbol 12-myristate 13-acetate (PMA, 10(-8) M) rapidly induced c-fos as well as c-Jun and Jun-B mRNA expression in RASM cells.	Tetradecanoylphorbol Acetate	93-96	angiotensinogen	Rattus norvegicus	0-6
2060147-7	1991	Five out of 13 adenomas secreted detectable amount of PRL into the medium and these five adenomas (100%) responded to TPA (16.0 nmol/l) with a two- to six-fold increase.	Tetradecanoylphorbol Acetate	118-121	prolactin	Homo sapiens	54-57
2015601-6	1991	TGF-beta-induced protection against TNF was observed in cells subjected to prolonged treatment with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	100-131	tumor necrosis factor	Mus musculus	36-39
1653054-6	1991	12-O-tetradecanoyl phorbol-13-acetate (TPA) but not 8-bromoadenosine 3",5"-cyclic monophosphate (Br-cAMP) induces changes in the morphology and associative behavior of ZR-75-1 cells that are similar but not identical to those caused by IL-6.	Tetradecanoylphorbol Acetate	0-37	interleukin 6	Homo sapiens	236-240
1653054-6	1991	12-O-tetradecanoyl phorbol-13-acetate (TPA) but not 8-bromoadenosine 3",5"-cyclic monophosphate (Br-cAMP) induces changes in the morphology and associative behavior of ZR-75-1 cells that are similar but not identical to those caused by IL-6.	Tetradecanoylphorbol Acetate	39-42	interleukin 6	Homo sapiens	236-240
2022708-12	1991	Agonist-induced PGE2 production was also assessed in cells in which PKC activity had been tachyphylaxed with a high concentration of PMA (400 ng/mL for 48 h).	Tetradecanoylphorbol Acetate	133-136	proline rich transmembrane protein 2	Homo sapiens	68-71
2022183-4	1991	In a human erythroleukemia cell line, HEL, the production of the latent form of TGF-beta 1 was induced more than 100-fold by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	125-156	transforming growth factor beta 1	Homo sapiens	80-90
2022306-8	1991	DiC8-induced rise in [Ca2+]i was also seen in cells that had been depleted of PKC by prior exposure to TPA.	Tetradecanoylphorbol Acetate	103-106	carbonic anhydrase 2	Mesocricetus auratus	22-25
2022923-5	1991	That PMNs may represent an important source of TGF-beta in inflammatory infiltrates was strongly suggested by a demonstration that stored TGF-beta 1 was secreted during phorbol myristate acetate-stimulated degranulation in vitro.	Tetradecanoylphorbol Acetate	169-194	transforming growth factor beta 1	Homo sapiens	47-55
2040654-1	1991	Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937.	Tetradecanoylphorbol Acetate	15-52	interleukin 1 beta	Homo sapiens	112-130
2040654-1	1991	Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937.	Tetradecanoylphorbol Acetate	15-52	interleukin 1 beta	Homo sapiens	132-141
2040654-1	1991	Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937.	Tetradecanoylphorbol Acetate	54-57	interleukin 1 beta	Homo sapiens	112-130
2040654-1	1991	Treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and incubation with lipopolysaccharide (LPS) induces interleukin 1 beta (IL-1 beta) production in the histiocytic lymphoma cell line U937.	Tetradecanoylphorbol Acetate	54-57	interleukin 1 beta	Homo sapiens	132-141
2040654-2	1991	Here we investigated the effect of treatment with both TPA and 1 alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) on LPS-induced IL-1 beta production in U937 cells.	Tetradecanoylphorbol Acetate	55-58	interleukin 1 beta	Homo sapiens	124-133
2040654-4	1991	Combined treatment with TPA and 1,25(OH)2D3 for 72 h followed by incubation with LPS for 24 h caused synergistic induction of both IL-1 beta release and mRNA expression.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 beta	Homo sapiens	131-140
2022923-5	1991	That PMNs may represent an important source of TGF-beta in inflammatory infiltrates was strongly suggested by a demonstration that stored TGF-beta 1 was secreted during phorbol myristate acetate-stimulated degranulation in vitro.	Tetradecanoylphorbol Acetate	169-194	transforming growth factor beta 1	Homo sapiens	138-148
1675782-0	1991	TPA inhibits the tyrosine kinase activity of the neu protein in vivo and in vitro.	Tetradecanoylphorbol Acetate	0-3	erb-b2 receptor tyrosine kinase 2	Homo sapiens	49-52
1903479-4	1991	In human lung fibroblasts and in human umbilical vein endothelial cells, LIF was constitutively expressed and its accumulation was increased in a time-dependent manner following treatment with the phorbol ester TPA and in the presence of the two immediate response cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1-beta.	Tetradecanoylphorbol Acetate	211-214	tumor necrosis factor	Homo sapiens	275-308
1903479-4	1991	In human lung fibroblasts and in human umbilical vein endothelial cells, LIF was constitutively expressed and its accumulation was increased in a time-dependent manner following treatment with the phorbol ester TPA and in the presence of the two immediate response cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1-beta.	Tetradecanoylphorbol Acetate	211-214	interleukin 1 beta	Homo sapiens	313-336
1905699-1	1991	Okadaic acid and dinophysistoxin-1 are non-12-O-tetradecanoylphorbol-13-acetate (non-TPA)-type tumor promoters, which enhance chemically induced tumorigenesis on mouse skin through a different mechanism from that of TPA.	Tetradecanoylphorbol Acetate	43-79	promotion susceptibility QTL 1	Mus musculus	85-88
1901945-1	1991	Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages.	Tetradecanoylphorbol Acetate	109-145	interferon gamma	Homo sapiens	30-46
1901945-1	1991	Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages.	Tetradecanoylphorbol Acetate	109-145	interferon gamma	Homo sapiens	48-57
1901945-1	1991	Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages.	Tetradecanoylphorbol Acetate	147-150	interferon gamma	Homo sapiens	30-46
1901945-1	1991	Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages.	Tetradecanoylphorbol Acetate	147-150	interferon gamma	Homo sapiens	48-57
1901945-6	1991	These results indicated that IFN gamma inhibited c-fos mRNA induction by TPA at the posttranscriptional level.	Tetradecanoylphorbol Acetate	73-76	interferon gamma	Homo sapiens	29-38
2013762-8	1991	Additionally, PK-C phosphorylated some tryptic peptide fragments of these proteins that were not observed with PMA treatment in intact cells.	Tetradecanoylphorbol Acetate	111-114	proline rich transmembrane protein 2	Homo sapiens	14-18
1667763-1	1991	The present study examines the effect of reduction of protein kinase C (PKC) activity, as induced by either phorbol ester (PMA) down-regulation or staurosporine inhibition, on the secretion of ACTH from cultured anterior pituitary (AP) cells.	Tetradecanoylphorbol Acetate	123-126	proopiomelanocortin	Homo sapiens	193-197
1667763-2	1991	Short-term (3 h) exposure of cells to 5 nM PMA resulted in almost complete desensitization to both PMA and vasopressin (AVP), while there was only a minor incidence on the effect of corticotropin-releasing factor (CRF).	Tetradecanoylphorbol Acetate	43-46	arginine vasopressin	Homo sapiens	107-118
2017159-8	1991	We further show that VGF mRNA is induced in PC12 cells to a greater extent by depolarization and by phorbol-12-myristate-13-acetate treatment than by 8-bromo-cyclic AMP treatment.	Tetradecanoylphorbol Acetate	100-131	VGF nerve growth factor inducible	Rattus norvegicus	21-24
1675782-3	1991	We report here that incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates the phosphorylation of the normal neu protein (p185) and the oncogenic neu protein (p185*).	Tetradecanoylphorbol Acetate	45-81	erb-b2 receptor tyrosine kinase 2	Homo sapiens	133-136
1675782-3	1991	We report here that incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates the phosphorylation of the normal neu protein (p185) and the oncogenic neu protein (p185*).	Tetradecanoylphorbol Acetate	45-81	erb-b2 receptor tyrosine kinase 2	Homo sapiens	170-173
1675782-3	1991	We report here that incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates the phosphorylation of the normal neu protein (p185) and the oncogenic neu protein (p185*).	Tetradecanoylphorbol Acetate	83-86	erb-b2 receptor tyrosine kinase 2	Homo sapiens	133-136
1675782-3	1991	We report here that incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates the phosphorylation of the normal neu protein (p185) and the oncogenic neu protein (p185*).	Tetradecanoylphorbol Acetate	83-86	erb-b2 receptor tyrosine kinase 2	Homo sapiens	170-173
1707668-2	1991	TPA, a tumor-promoting phorbol ester, stimulated a dose-dependent increase in TSH beta promoter activity at 8 h similar to TRH (2-3-fold).	Tetradecanoylphorbol Acetate	0-3	thyroid stimulating hormone subunit beta	Rattus norvegicus	78-86
1820763-1	1991	A model for the binding of two activators of protein kinase C (PKC), the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and diacylglycerol, to the enzyme is proposed.	Tetradecanoylphorbol Acetate	125-128	proline rich transmembrane protein 2	Homo sapiens	45-61
1820763-1	1991	A model for the binding of two activators of protein kinase C (PKC), the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and diacylglycerol, to the enzyme is proposed.	Tetradecanoylphorbol Acetate	125-128	proline rich transmembrane protein 2	Homo sapiens	63-66
1851004-1	1991	Pretreatment of UMR-106 cells (rat osteoblast like osteosarcoma cell line) with the protein kinase C(PK-C) activating phorbol ester, phorbol 12-myristate 13-acetate (PMA) results in a time dependent (1-12h) desensitization of PTH-stimulated cAMP production.	Tetradecanoylphorbol Acetate	133-164	parathyroid hormone	Rattus norvegicus	226-229
2016320-8	1991	CD6 is phosphorylated in resting cells and can be hyperphosphorylated when stimulated by phorbol 12-myristate 13-acetate, indicating that it may participate in the major common signaling pathway mediated through protein kinase C. Concanavalin A-activated cells are phosphorylated at an additional site(s) on the molecule and cannot be hyperphosphorylated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	89-120	CD6 molecule	Homo sapiens	0-3
2016320-8	1991	CD6 is phosphorylated in resting cells and can be hyperphosphorylated when stimulated by phorbol 12-myristate 13-acetate, indicating that it may participate in the major common signaling pathway mediated through protein kinase C. Concanavalin A-activated cells are phosphorylated at an additional site(s) on the molecule and cannot be hyperphosphorylated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	360-391	CD6 molecule	Homo sapiens	0-3
2018470-4	1991	The PMA-induced stimulation of both transport and transporter translocation was substantially less than that induced by insulin in this cell line; the PMA-induced increase in plasma-membrane GLUT 1 and GLUT 4 transporter isoforms was only about 40% and 10% respectively of that induced by insulin.	Tetradecanoylphorbol Acetate	4-7	insulin	Homo sapiens	289-296
1707674-7	1991	In cells pretreated with TPA the bradykinin-induced increase of inositol trisphosphate formation is blunted, the bradykinin-induced increase of Cai abolished, but the bradykinin-induced hyperpolarization still present.	Tetradecanoylphorbol Acetate	25-28	kininogen 1	Canis lupus familiaris	33-43
1707674-7	1991	In cells pretreated with TPA the bradykinin-induced increase of inositol trisphosphate formation is blunted, the bradykinin-induced increase of Cai abolished, but the bradykinin-induced hyperpolarization still present.	Tetradecanoylphorbol Acetate	25-28	kininogen 1	Canis lupus familiaris	113-123
1707674-7	1991	In cells pretreated with TPA the bradykinin-induced increase of inositol trisphosphate formation is blunted, the bradykinin-induced increase of Cai abolished, but the bradykinin-induced hyperpolarization still present.	Tetradecanoylphorbol Acetate	25-28	kininogen 1	Canis lupus familiaris	113-123
2018470-4	1991	The PMA-induced stimulation of both transport and transporter translocation was substantially less than that induced by insulin in this cell line; the PMA-induced increase in plasma-membrane GLUT 1 and GLUT 4 transporter isoforms was only about 40% and 10% respectively of that induced by insulin.	Tetradecanoylphorbol Acetate	151-154	insulin	Homo sapiens	120-127
2018470-4	1991	The PMA-induced stimulation of both transport and transporter translocation was substantially less than that induced by insulin in this cell line; the PMA-induced increase in plasma-membrane GLUT 1 and GLUT 4 transporter isoforms was only about 40% and 10% respectively of that induced by insulin.	Tetradecanoylphorbol Acetate	151-154	insulin	Homo sapiens	289-296
1850359-6	1991	Moreover, phorbol 12-myristate 13-acetate led to an early, marked down-regulation of the 75-kDa TNFR expression, followed by a later modest increase after greater than 24 h. In contrast to other cell systems where htr mAb have been found either to mimic or to inhibit TNF action, htr mAb had insignificant effects in assays for restimulation of preactivated B cells.	Tetradecanoylphorbol Acetate	10-41	telomerase RNA component	Homo sapiens	214-217
1905574-6	1991	A short-term treatment of the undifferentiated Tera 2 cells with basic fibroblast growth factor (bFGF) increases uPA mRNA levels and the cell-associated uPA activity, whereas the secretory tPA activity decreases.	Tetradecanoylphorbol Acetate	189-192	fibroblast growth factor 2	Homo sapiens	97-101
2059661-1	1991	NF-kappa B can be activated by a number of stimuli, including pharmacological stimulation of protein kinase C by phorbol 12-myristate 13-acetate (PMA) and treatment in vitro with either protein kinase C or protein kinase A.	Tetradecanoylphorbol Acetate	113-144	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-10
2059661-1	1991	NF-kappa B can be activated by a number of stimuli, including pharmacological stimulation of protein kinase C by phorbol 12-myristate 13-acetate (PMA) and treatment in vitro with either protein kinase C or protein kinase A.	Tetradecanoylphorbol Acetate	146-149	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-10
2059661-5	1991	First, the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) strongly inhibited PMA-induced activation of NF-kappa B in 70Z/3 cells but had no effect on NF-kappa B activated by IL-1 or LPS.	Tetradecanoylphorbol Acetate	109-112	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-145
2059661-5	1991	First, the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) strongly inhibited PMA-induced activation of NF-kappa B in 70Z/3 cells but had no effect on NF-kappa B activated by IL-1 or LPS.	Tetradecanoylphorbol Acetate	109-112	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	182-192
1672274-1	1991	Pyroglutamyl peptidase II (EC 3.4.19.-), a highly specific membrane-bound TRH-degrading enzyme, is inactivated in Y-79 human retinoblastoma cells by exposure to 12-O-tetradecanoyl phorbol-13-acetate (TPA) in a biphasic manner.	Tetradecanoylphorbol Acetate	161-198	thyrotropin releasing hormone degrading enzyme	Homo sapiens	0-25
1672274-1	1991	Pyroglutamyl peptidase II (EC 3.4.19.-), a highly specific membrane-bound TRH-degrading enzyme, is inactivated in Y-79 human retinoblastoma cells by exposure to 12-O-tetradecanoyl phorbol-13-acetate (TPA) in a biphasic manner.	Tetradecanoylphorbol Acetate	200-203	thyrotropin releasing hormone degrading enzyme	Homo sapiens	0-25
1672274-2	1991	We have previously demonstrated a rapid decrease in pyroglutamyl peptidase II activity to 10% of the control level within 15 min, which returns to 70% of the control level by 1 h. This decrease results from enzyme phosphorylation by TPA-activated protein kinase-C. We now report a second phase of inactivation after longer exposure of cells to TPA.	Tetradecanoylphorbol Acetate	233-236	thyrotropin releasing hormone degrading enzyme	Homo sapiens	52-77
1672274-2	1991	We have previously demonstrated a rapid decrease in pyroglutamyl peptidase II activity to 10% of the control level within 15 min, which returns to 70% of the control level by 1 h. This decrease results from enzyme phosphorylation by TPA-activated protein kinase-C. We now report a second phase of inactivation after longer exposure of cells to TPA.	Tetradecanoylphorbol Acetate	344-347	thyrotropin releasing hormone degrading enzyme	Homo sapiens	52-77
1672274-6	1991	Immunoblot experiments demonstrated a reduction in the amount of pyroglutamyl peptidase II in Y-79 membranes after long term exposure to TPA.	Tetradecanoylphorbol Acetate	137-140	thyrotropin releasing hormone degrading enzyme	Homo sapiens	65-90
1850359-6	1991	Moreover, phorbol 12-myristate 13-acetate led to an early, marked down-regulation of the 75-kDa TNFR expression, followed by a later modest increase after greater than 24 h. In contrast to other cell systems where htr mAb have been found either to mimic or to inhibit TNF action, htr mAb had insignificant effects in assays for restimulation of preactivated B cells.	Tetradecanoylphorbol Acetate	10-41	telomerase RNA component	Homo sapiens	280-283
1651364-7	1991	HL-60 cells cultivated with 100 U/ml IFN-gamma produced increased O2- when exposed to 25 mM NaF (containing AIF4) or 10 nM phorbol myristate acetate, agonists that trigger the respiratory burst independent of receptor stimulation.	Tetradecanoylphorbol Acetate	123-148	interferon gamma	Homo sapiens	37-46
1709941-2	1991	Activation of PKC by phorbol 12-myristate 13-acetate (PMA) caused a potentiation of cAMP accumulation induced by parathyroid hormone (PTH), forskolin, and cholera toxin.	Tetradecanoylphorbol Acetate	21-52	parathyroid hormone	Rattus norvegicus	113-132
1709941-2	1991	Activation of PKC by phorbol 12-myristate 13-acetate (PMA) caused a potentiation of cAMP accumulation induced by parathyroid hormone (PTH), forskolin, and cholera toxin.	Tetradecanoylphorbol Acetate	54-57	parathyroid hormone	Rattus norvegicus	113-132
1871174-1	1991	Phorbolmyristate acetate or 12-O-tetradecanyl phorbol 13-acetate (PMA or TPA) stimulates membrane phospholipases (phospholipase C or A2) resulting in the formation of diacylglyceride, free arachidonic acid, and increased amounts of arachidonic acid metabolites.	Tetradecanoylphorbol Acetate	0-24	phospholipase A2 group IB	Homo sapiens	114-135
1651769-9	1991	Analysis of costimulation experiments conducted with these three factors and TPA confirmed these results and gave evidence that fMLP activates two different signaling pathways, one of which is PKC dependent, while the other is not.	Tetradecanoylphorbol Acetate	77-80	formyl peptide receptor 1	Homo sapiens	128-132
1651769-9	1991	Analysis of costimulation experiments conducted with these three factors and TPA confirmed these results and gave evidence that fMLP activates two different signaling pathways, one of which is PKC dependent, while the other is not.	Tetradecanoylphorbol Acetate	77-80	proline rich transmembrane protein 2	Homo sapiens	193-196
2002283-2	1991	Treatment of neutrophils with low concentrations of PMA (0.2-0.5 ng/ml) for 18 hr at 37 degrees C markedly enhanced cytotoxicity triggered by Ca2+ ionophore A23187, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and PMA.	Tetradecanoylphorbol Acetate	52-55	formyl peptide receptor 1	Homo sapiens	206-210
1871174-1	1991	Phorbolmyristate acetate or 12-O-tetradecanyl phorbol 13-acetate (PMA or TPA) stimulates membrane phospholipases (phospholipase C or A2) resulting in the formation of diacylglyceride, free arachidonic acid, and increased amounts of arachidonic acid metabolites.	Tetradecanoylphorbol Acetate	66-69	phospholipase A2 group IB	Homo sapiens	114-135
1871174-1	1991	Phorbolmyristate acetate or 12-O-tetradecanyl phorbol 13-acetate (PMA or TPA) stimulates membrane phospholipases (phospholipase C or A2) resulting in the formation of diacylglyceride, free arachidonic acid, and increased amounts of arachidonic acid metabolites.	Tetradecanoylphorbol Acetate	73-76	phospholipase A2 group IB	Homo sapiens	114-135
2009307-1	1991	The protein kinase C activator phorbol 12-myristate 13-acetate (TPA) augments the level of cytoplasmic mRNA for cytoskeletal actin and the beta chain of the T cell antigen receptor (TCR beta) in peripheral blood lymphocytes.	Tetradecanoylphorbol Acetate	31-62	T cell receptor beta locus	Homo sapiens	182-190
1848242-1	1991	We have studied the effect of the tumor promotor phorbol myristate acetate (PMA) on the level of mRNA for the receptor for urokinase-type plasminogen activator (u-PAR) in the human monocyte-like cell line U937.	Tetradecanoylphorbol Acetate	49-74	plasminogen activator, urokinase	Homo sapiens	123-159
2009307-1	1991	The protein kinase C activator phorbol 12-myristate 13-acetate (TPA) augments the level of cytoplasmic mRNA for cytoskeletal actin and the beta chain of the T cell antigen receptor (TCR beta) in peripheral blood lymphocytes.	Tetradecanoylphorbol Acetate	64-67	T cell receptor beta locus	Homo sapiens	182-190
1901021-3	1991	To examine whether endocytic vesicles which contain the vasopressin-sensitive water channel fuse with acidic vesicles for entry into a lysosomal pathway, ATP-dependent acidification and osmotic water permeability were measured in endosomes from control bladders and bladders treated with vasopressin (VP) and/or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	312-337	arginine vasopressin	Homo sapiens	56-67
1901021-3	1991	To examine whether endocytic vesicles which contain the vasopressin-sensitive water channel fuse with acidic vesicles for entry into a lysosomal pathway, ATP-dependent acidification and osmotic water permeability were measured in endosomes from control bladders and bladders treated with vasopressin (VP) and/or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	339-342	arginine vasopressin	Homo sapiens	56-67
1848242-1	1991	We have studied the effect of the tumor promotor phorbol myristate acetate (PMA) on the level of mRNA for the receptor for urokinase-type plasminogen activator (u-PAR) in the human monocyte-like cell line U937.	Tetradecanoylphorbol Acetate	49-74	plasminogen activator, urokinase	Homo sapiens	161-166
1848242-1	1991	We have studied the effect of the tumor promotor phorbol myristate acetate (PMA) on the level of mRNA for the receptor for urokinase-type plasminogen activator (u-PAR) in the human monocyte-like cell line U937.	Tetradecanoylphorbol Acetate	76-79	plasminogen activator, urokinase	Homo sapiens	123-159
1848242-1	1991	We have studied the effect of the tumor promotor phorbol myristate acetate (PMA) on the level of mRNA for the receptor for urokinase-type plasminogen activator (u-PAR) in the human monocyte-like cell line U937.	Tetradecanoylphorbol Acetate	76-79	plasminogen activator, urokinase	Homo sapiens	161-166
1848086-10	1991	SP-A inhibited TPA-stimulated [3H]PC secretion similarly in type II cells isolated after either silica or saline instillation.	Tetradecanoylphorbol Acetate	15-18	surfactant protein A1	Rattus norvegicus	0-4
1652965-3	1991	The constitutive gene expression of C4bp alpha by a hepatoma line, HepG2, was significantly augmented by treatment with monocyte-conditioned medium (MoCM), 12-O-tetradecanoylphorbol-13-acetate (TPA), interleukin-6 (IL6) and tumor necrosis factor (TNF) but not by a calcium ionophore (A23187) or interleukin-1 beta (IL1 beta).	Tetradecanoylphorbol Acetate	194-197	complement component 4 binding protein alpha	Homo sapiens	36-46
1899359-4	1991	Supernatants from PHA-stimulated adult macrophages and phorbol myristate acetate (PMA)-stimulated U937 cells (which were dialyzed prior to culture to remove PMA) increased IFN-gamma production in neonatal PHA-stimulated MNC (14 to 217 units/ml and 14 to 293 units/ml, respectively).	Tetradecanoylphorbol Acetate	55-80	interferon gamma	Homo sapiens	172-181
1899359-4	1991	Supernatants from PHA-stimulated adult macrophages and phorbol myristate acetate (PMA)-stimulated U937 cells (which were dialyzed prior to culture to remove PMA) increased IFN-gamma production in neonatal PHA-stimulated MNC (14 to 217 units/ml and 14 to 293 units/ml, respectively).	Tetradecanoylphorbol Acetate	82-85	interferon gamma	Homo sapiens	172-181
1899359-4	1991	Supernatants from PHA-stimulated adult macrophages and phorbol myristate acetate (PMA)-stimulated U937 cells (which were dialyzed prior to culture to remove PMA) increased IFN-gamma production in neonatal PHA-stimulated MNC (14 to 217 units/ml and 14 to 293 units/ml, respectively).	Tetradecanoylphorbol Acetate	157-160	interferon gamma	Homo sapiens	172-181
1899359-7	1991	Furthermore, the increased IFN-gamma production by PHA-stimulated cord blood MNC in the presence of PHA-stimulated adult macrophage supernatant or PMA-stimulated U937 supernatant was abrogated by the addition of MnCl2, chlorpromazine, and verapamil.	Tetradecanoylphorbol Acetate	147-150	interferon gamma	Homo sapiens	27-36
1847859-7	1991	In fetal cultures TPA slightly increased P450scc, P450c11, and P450c21 mRNA levels, whereas it decreased P450c17 mRNA.	Tetradecanoylphorbol Acetate	18-21	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	41-48
1847859-10	1991	The secretion of ACTH-stimulated cortisol, dehydroepiandrosterone sulfate, and aldosterone was decreased by TPA in both fetal and adult cultures.	Tetradecanoylphorbol Acetate	108-111	proopiomelanocortin	Homo sapiens	17-21
1847859-13	1991	Our results show that the inhibitory effect of TPA on ACTH-stimulated adrenal steroidogenesis is mediated at the mRNA level of steroidogenic enzymes.	Tetradecanoylphorbol Acetate	47-50	proopiomelanocortin	Homo sapiens	54-58
1704842-11	1991	Internalization of CD4 was induced by PMA, but PMA failed to induce cytotoxicity of CD4-targeted liposomes for CEM.MRS.	Tetradecanoylphorbol Acetate	38-41	CD4 molecule	Homo sapiens	19-22
2009915-1	1991	Northern blot analysis indicated that the mRNA for human properdin is approximately 1.5 kb long and that its level in U-937 cells is increased by pretreating the cells with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	173-204	complement factor properdin	Homo sapiens	57-66
2009915-1	1991	Northern blot analysis indicated that the mRNA for human properdin is approximately 1.5 kb long and that its level in U-937 cells is increased by pretreating the cells with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	206-209	complement factor properdin	Homo sapiens	57-66
1705566-6	1991	TNF probably exerts its effect through activation of protein kinase C (PKC) as the TNF effect on G-CSF receptor levels can be mimicked by 12-O-tetradecanoylphorbol-13- acetate.	Tetradecanoylphorbol Acetate	138-175	tumor necrosis factor	Homo sapiens	0-3
1851783-6	1991	Arteries from rats undergoing DOCA-salt treatment for 5-7 days and from DOCA-treated rats drinking tap water for 4-6 weeks were less responsive to TPA than were arteries from the DOCA-salt hypertensive rats after 4-6 weeks of treatment.	Tetradecanoylphorbol Acetate	147-150	nuclear RNA export factor 1	Rattus norvegicus	99-102
1899696-1	1991	Fresh brain-tumor samples were obtained at operation and analyzed for their content of tissue type plasminogen activator (tPA) using an activity assay (gel chromatography zymogram) and an enzyme-linked immunospecific assay.	Tetradecanoylphorbol Acetate	122-125	plasminogen activator, tissue type	Homo sapiens	87-120
2011401-3	1991	In unstimulated proliferating JURKAT cells, high levels of C-MYC, N-RAS, and BCL2 mRNAs were found that diminished rapidly following TPA-induced cessation of growth.	Tetradecanoylphorbol Acetate	133-136	BCL2 apoptosis regulator	Homo sapiens	77-81
2011401-8	1991	Thus, although C-MYC and BCL2 proto-oncogene expression correlated with proliferation in TPA-treated JURKAT cells, continuous over-expression of even the combination of these oncogenes was insufficient for abrogating the effects of TPA in these leukemic T cells.	Tetradecanoylphorbol Acetate	89-92	BCL2 apoptosis regulator	Homo sapiens	25-29
1903523-4	1991	High doses of recombinant IL-2, when added to in vitro cultures, were able to restore proliferation induced by phorbol myristate acetate and ionomycin but the response to concanavalin A remained severely defective.	Tetradecanoylphorbol Acetate	111-136	interleukin 2	Homo sapiens	26-30
1847936-2	1991	When stimulated with phorbol myristate acetate (PMA), both secretion of uPA and the expression of its receptor are up-regulated, and these cells differentiate to an adherent phenotype.	Tetradecanoylphorbol Acetate	21-46	plasminogen activator, urokinase	Homo sapiens	72-75
1847936-2	1991	When stimulated with phorbol myristate acetate (PMA), both secretion of uPA and the expression of its receptor are up-regulated, and these cells differentiate to an adherent phenotype.	Tetradecanoylphorbol Acetate	48-51	plasminogen activator, urokinase	Homo sapiens	72-75
1849601-0	1991	Down regulation of myeloperoxidase gene associated with specific nuclease hypersensitive sites during TPA induced differentiation of HL-60.	Tetradecanoylphorbol Acetate	102-105	myeloperoxidase	Homo sapiens	19-34
1849601-1	1991	The level of myeloperoxidase (MPO) mRNA is reduced significantly after HL-60 induced differentiation with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	125-161	myeloperoxidase	Homo sapiens	13-28
1849601-1	1991	The level of myeloperoxidase (MPO) mRNA is reduced significantly after HL-60 induced differentiation with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	125-161	myeloperoxidase	Homo sapiens	30-33
1849601-1	1991	The level of myeloperoxidase (MPO) mRNA is reduced significantly after HL-60 induced differentiation with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	163-166	myeloperoxidase	Homo sapiens	13-28
1849601-1	1991	The level of myeloperoxidase (MPO) mRNA is reduced significantly after HL-60 induced differentiation with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	163-166	myeloperoxidase	Homo sapiens	30-33
1849601-2	1991	We examined the chromatin structural changes of the MPO gene during TPA induction.	Tetradecanoylphorbol Acetate	68-71	myeloperoxidase	Homo sapiens	52-55
1849601-3	1991	Before TPA induction about nine DNase I hypersensitive sites (HS) were found on the 5" upstream and at various intron regions of the MPO gene.	Tetradecanoylphorbol Acetate	7-10	myeloperoxidase	Homo sapiens	133-136
1849601-5	1991	At the same time DNase I HS found in 0.3 and 1-1.5 kb upstream of the MPO CAP site, were significantly reduced or disappeared after TPA induction.	Tetradecanoylphorbol Acetate	132-135	myeloperoxidase	Homo sapiens	70-73
1648714-5	1991	Phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, and A23187 and its 4-bromo derivative, calcium ionophores, inhibited ANF-s-cGMP in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-31	natriuretic peptide A	Homo sapiens	144-147
1648714-5	1991	Phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, and A23187 and its 4-bromo derivative, calcium ionophores, inhibited ANF-s-cGMP in a dose-dependent manner.	Tetradecanoylphorbol Acetate	33-36	natriuretic peptide A	Homo sapiens	144-147
1648714-7	1991	Thirty-six hour preincubation with PMA, a procedure used to down-regulate PKC, abolished acute PMA inhibition of ANF-s-cGMP without having an effect on ANF-s-cGMP or on 4-bromo-A23187 inhibition thereof.	Tetradecanoylphorbol Acetate	35-38	natriuretic peptide A	Homo sapiens	113-116
1705566-6	1991	TNF probably exerts its effect through activation of protein kinase C (PKC) as the TNF effect on G-CSF receptor levels can be mimicked by 12-O-tetradecanoylphorbol-13- acetate.	Tetradecanoylphorbol Acetate	138-175	tumor necrosis factor	Homo sapiens	83-86
1899867-4	1991	Stimulation with arginine vasopressin, epidermal growth factor, or phorbol myristate acetate increased [3H]thymidine incorporation and mRNA levels of the immediate-early response genes c-fos and Egr-1.	Tetradecanoylphorbol Acetate	67-92	early growth response 1	Rattus norvegicus	195-200
1900155-6	1991	The role of Jun-containing TRE binding proteins in promoting B cell cycle progression remains uncertain inasmuch as Jun-B has been associated with transcriptional inhibition of the TPA response element, rather than activation as produced by c-Jun.	Tetradecanoylphorbol Acetate	181-184	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-121
2001408-12	1991	The treatment of neutrophils with antiserum against human plasma fibronectin inhibited the respiratory burst in response to formyl-methionyl-leucylphenylalanine (fMLP) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	172-203	fibronectin 1	Homo sapiens	65-76
2001408-12	1991	The treatment of neutrophils with antiserum against human plasma fibronectin inhibited the respiratory burst in response to formyl-methionyl-leucylphenylalanine (fMLP) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	205-208	fibronectin 1	Homo sapiens	65-76
1846746-3	1991	4 beta-phorbol 12-myristate 13-acetate (PMA) and 1,2-dioctanoyl-sn-glycerol, which directly activate PKC, stimulated the synthesis of PAF.	Tetradecanoylphorbol Acetate	40-43	proline rich transmembrane protein 2	Homo sapiens	101-104
1846616-10	1991	Pretreatment of the cells with ethanol enhanced the inhibitory effects of TPA on the vasopressin-induced phospholipase C activation at all concentrations of the hormone; however, these synergistic effects were prevented when TPA was added prior to ethanol, a condition that prevents the activation of phospholipase C by ethanol.	Tetradecanoylphorbol Acetate	74-77	arginine vasopressin	Rattus norvegicus	85-96
1846616-10	1991	Pretreatment of the cells with ethanol enhanced the inhibitory effects of TPA on the vasopressin-induced phospholipase C activation at all concentrations of the hormone; however, these synergistic effects were prevented when TPA was added prior to ethanol, a condition that prevents the activation of phospholipase C by ethanol.	Tetradecanoylphorbol Acetate	225-228	arginine vasopressin	Rattus norvegicus	85-96
1846746-4	1991	Sphingosine, a long-chain amine that inhibits PKC, blocked both the binding of phorbol esters to monocytes and the synthesis of PAF in response to PMA (half-maximal inhibition at 5 to 10 microM and complete inhibition at 10 to 30 microM sphingosine).	Tetradecanoylphorbol Acetate	147-150	proline rich transmembrane protein 2	Homo sapiens	46-49
1846746-3	1991	4 beta-phorbol 12-myristate 13-acetate (PMA) and 1,2-dioctanoyl-sn-glycerol, which directly activate PKC, stimulated the synthesis of PAF.	Tetradecanoylphorbol Acetate	0-38	proline rich transmembrane protein 2	Homo sapiens	101-104
1846589-3	1991	A 1-h exposure to 3 x 10(-7)-3 x 10(-6) M phorbol-12-myristate-13-acetate (PMA) significantly attenuated the cAMP response to AVP (1 x 10(-9) M AVP; 474.9 +/- 24.8 vs. 368.1 +/- 22.8 fmol/microgram protein; P less than 0.01).	Tetradecanoylphorbol Acetate	42-73	arginine vasopressin	Rattus norvegicus	126-129
2032310-1	1991	G0-arrested human diploid fibroblasts, TIG-1, was stimulated to induce DNA synthesis by serum, epidermal growth factor (EGF), colchicine, colcemid, or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	151-187	retinoic acid receptor responder 1	Homo sapiens	39-44
2032310-1	1991	G0-arrested human diploid fibroblasts, TIG-1, was stimulated to induce DNA synthesis by serum, epidermal growth factor (EGF), colchicine, colcemid, or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	189-192	retinoic acid receptor responder 1	Homo sapiens	39-44
2032310-2	1991	The induction of DNA synthesis was mediated by protein kinase C (PKC) when stimulated with TPA but not when stimulated with other agents.	Tetradecanoylphorbol Acetate	91-94	proline rich transmembrane protein 2	Homo sapiens	47-63
2032310-2	1991	The induction of DNA synthesis was mediated by protein kinase C (PKC) when stimulated with TPA but not when stimulated with other agents.	Tetradecanoylphorbol Acetate	91-94	proline rich transmembrane protein 2	Homo sapiens	65-68
2032310-9	1991	These results suggest that the inhibitory effect of TPA on the induction of DNA synthesis by colcemid is mediated by down regulation-sensitive and staurosporine-insensitive PKC.	Tetradecanoylphorbol Acetate	52-55	proline rich transmembrane protein 2	Homo sapiens	173-176
1846589-3	1991	A 1-h exposure to 3 x 10(-7)-3 x 10(-6) M phorbol-12-myristate-13-acetate (PMA) significantly attenuated the cAMP response to AVP (1 x 10(-9) M AVP; 474.9 +/- 24.8 vs. 368.1 +/- 22.8 fmol/microgram protein; P less than 0.01).	Tetradecanoylphorbol Acetate	42-73	arginine vasopressin	Rattus norvegicus	144-147
1846589-3	1991	A 1-h exposure to 3 x 10(-7)-3 x 10(-6) M phorbol-12-myristate-13-acetate (PMA) significantly attenuated the cAMP response to AVP (1 x 10(-9) M AVP; 474.9 +/- 24.8 vs. 368.1 +/- 22.8 fmol/microgram protein; P less than 0.01).	Tetradecanoylphorbol Acetate	75-78	arginine vasopressin	Rattus norvegicus	126-129
1846589-3	1991	A 1-h exposure to 3 x 10(-7)-3 x 10(-6) M phorbol-12-myristate-13-acetate (PMA) significantly attenuated the cAMP response to AVP (1 x 10(-9) M AVP; 474.9 +/- 24.8 vs. 368.1 +/- 22.8 fmol/microgram protein; P less than 0.01).	Tetradecanoylphorbol Acetate	75-78	arginine vasopressin	Rattus norvegicus	144-147
1846589-6	1991	When cells were preexposed to 1 x 10(-6) M PMA, an increase in [Ca2+]i in response to 1 x 10(-7) M AVP was significantly diminished (75.5 +/- 4.6 to 101.4 +/- 4.3 nM).	Tetradecanoylphorbol Acetate	43-46	arginine vasopressin	Rattus norvegicus	99-102
2032553-1	1991	Treatment of neutrophils with phorbol myristate acetate (PMA) increases surface expression of CR3 (iC3b-receptor; CD11b/CD18).	Tetradecanoylphorbol Acetate	30-55	integrin subunit beta 2	Homo sapiens	120-124
2032553-1	1991	Treatment of neutrophils with phorbol myristate acetate (PMA) increases surface expression of CR3 (iC3b-receptor; CD11b/CD18).	Tetradecanoylphorbol Acetate	57-60	integrin subunit beta 2	Homo sapiens	120-124
1846590-5	1991	Potentiation of the cAMP response to VIP can be produced in LD cells by treatment with agents that elevate intracellular Ca2+ (depolarizing concentrations of K+ or A23187) or an activator of protein kinase-C [14 beta-phorbol 12-myristate 13-acetate (PMA)].	Tetradecanoylphorbol Acetate	212-248	vasoactive intestinal peptide	Rattus norvegicus	37-40
1846590-5	1991	Potentiation of the cAMP response to VIP can be produced in LD cells by treatment with agents that elevate intracellular Ca2+ (depolarizing concentrations of K+ or A23187) or an activator of protein kinase-C [14 beta-phorbol 12-myristate 13-acetate (PMA)].	Tetradecanoylphorbol Acetate	250-253	vasoactive intestinal peptide	Rattus norvegicus	37-40
1846590-7	1991	In contrast, LL treatment augmented the PMA potentiation of VIP-stimulated cAMP response.	Tetradecanoylphorbol Acetate	40-43	vasoactive intestinal peptide	Rattus norvegicus	60-63
1999477-13	1991	In addition, PMA inhibited thrombin-induced DNA synthesis when added at the same time or as late as 10 hours after thrombin addition.	Tetradecanoylphorbol Acetate	13-16	coagulation factor II, thrombin	Homo sapiens	27-35
1999477-13	1991	In addition, PMA inhibited thrombin-induced DNA synthesis when added at the same time or as late as 10 hours after thrombin addition.	Tetradecanoylphorbol Acetate	13-16	coagulation factor II, thrombin	Homo sapiens	115-123
1999477-14	1991	Therefore, thrombin and PMA activate Na+/H+ exchange by distinct pathways, but only the thrombin-induced pathway correlates with a mitogenic response.	Tetradecanoylphorbol Acetate	24-27	coagulation factor II, thrombin	Homo sapiens	88-96
1899098-7	1991	However, when differentiation was induced in these cells by TPA or IFN-gamma, the additive effect of TNF-alpha on the IFN-gamma induced DR expression was eliminated.	Tetradecanoylphorbol Acetate	60-63	tumor necrosis factor	Homo sapiens	101-110
1899098-7	1991	However, when differentiation was induced in these cells by TPA or IFN-gamma, the additive effect of TNF-alpha on the IFN-gamma induced DR expression was eliminated.	Tetradecanoylphorbol Acetate	60-63	interferon gamma	Homo sapiens	118-127
1903142-11	1991	Further, the TPA-induced attenuation of IFN-gamma receptor upregulation suggests that protein kinase C activation can regulate the TNF/LT-mediated pathways involved in IFN-gamma receptor upregulation.	Tetradecanoylphorbol Acetate	13-16	interferon gamma	Homo sapiens	40-49
1903142-11	1991	Further, the TPA-induced attenuation of IFN-gamma receptor upregulation suggests that protein kinase C activation can regulate the TNF/LT-mediated pathways involved in IFN-gamma receptor upregulation.	Tetradecanoylphorbol Acetate	13-16	tumor necrosis factor	Homo sapiens	131-134
1903142-11	1991	Further, the TPA-induced attenuation of IFN-gamma receptor upregulation suggests that protein kinase C activation can regulate the TNF/LT-mediated pathways involved in IFN-gamma receptor upregulation.	Tetradecanoylphorbol Acetate	13-16	interferon gamma	Homo sapiens	168-177
1992343-6	1991	In revertant cells, DNA replication induced by serum or TPA was eliminated or reduced proportionately to the reduction in Raf protein levels.	Tetradecanoylphorbol Acetate	56-59	zinc fingers and homeoboxes 2	Mus musculus	122-125
19912783-5	1991	Treatment with both PMA and dbcAMP induces a threefold increase in nAChR expression, whereas treatment with NaBu alone or with PMA induces an 80% decrease in I-Bgt binding site expression.	Tetradecanoylphorbol Acetate	20-23	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	67-72
1648383-7	1991	Treatment of our cultures with phorbol myristate acetate, lipopolysaccharide, tumor necrosis factor alpha, and norepinephrine for 24 hours led to only a moderate elevation of endothelin-1 immunoreactivity.	Tetradecanoylphorbol Acetate	31-56	endothelin 1	Rattus norvegicus	175-187
1708162-4	1991	As expected, activation of protein kinase C by TPA increased both CD40 and CD43.	Tetradecanoylphorbol Acetate	47-50	sialophorin	Homo sapiens	75-79
1708162-6	1991	However, in the presence of TPA, ionomycin further up-regulated CD43 but not CD40.	Tetradecanoylphorbol Acetate	28-31	sialophorin	Homo sapiens	64-68
1847252-5	1991	PHA plus anti-CD28 or PMA plus anti-CD28-induced IL-2 synthesis was inhibited by genistein, and CsA, though it inhibited the PHA plus PMA-stimulated IL-2 synthesis, failed to have any effect on PMA plus anti-CD28-induced IL-2 synthesis.	Tetradecanoylphorbol Acetate	22-25	interleukin 2	Homo sapiens	49-53
1901643-3	1991	This fragment contains a sequence with a high degree of similarity to the binding site for the transcription factor activator protein-1 (AP-1) and indeed, the AP-1 sequence of this fragment is necessary but not sufficient for the maximal response to phorbol 12-myristate 13-acetate (phorbol) or interleukin-1.	Tetradecanoylphorbol Acetate	250-281	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-135
2026453-0	1991	High-affinity interleukin 2 receptors on B cell chronic lymphocytic leukemia cells are induced by phorbol myristate acetate but not by calcium ionophore.	Tetradecanoylphorbol Acetate	98-123	interleukin 2	Homo sapiens	14-27
1901643-3	1991	This fragment contains a sequence with a high degree of similarity to the binding site for the transcription factor activator protein-1 (AP-1) and indeed, the AP-1 sequence of this fragment is necessary but not sufficient for the maximal response to phorbol 12-myristate 13-acetate (phorbol) or interleukin-1.	Tetradecanoylphorbol Acetate	250-281	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-141
1901643-3	1991	This fragment contains a sequence with a high degree of similarity to the binding site for the transcription factor activator protein-1 (AP-1) and indeed, the AP-1 sequence of this fragment is necessary but not sufficient for the maximal response to phorbol 12-myristate 13-acetate (phorbol) or interleukin-1.	Tetradecanoylphorbol Acetate	250-281	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	159-163
1703443-6	1991	In addition, accumulation of c-fos mRNA by insulin/dexamethasone/methylisobutylxanthine was enhanced in protein kinase C-depleted cells pretreated with phorbol 12-myristate 13-acetate, indicating that protein kinase C may negatively regulate c-fos expression induced by insulin/dexamethasone/methylisobutylxanthine.	Tetradecanoylphorbol Acetate	152-183	insulin	Homo sapiens	43-50
2026453-4	1991	Radiolabeled IL2 binding assays also demonstrated that PMA induced both high-affinity IL2R (HA-IL2R) and low-affinity IL2R (LA-IL2R) on B-CLL cells, but that A23187 did not.	Tetradecanoylphorbol Acetate	55-58	interleukin 2	Homo sapiens	13-16
1703413-9	1991	Similarly, staurosporine, a relatively selective inhibitor of protein kinase C, and the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) an activator of this enzyme, both have pronounced effects on IgE-mediated histamine release from SMC but were completely inactive with regard to [DArg0-Hyp3-DPhe7]-bradykinin-stimulated release.	Tetradecanoylphorbol Acetate	103-139	kininogen 1	Homo sapiens	310-320
1703413-9	1991	Similarly, staurosporine, a relatively selective inhibitor of protein kinase C, and the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) an activator of this enzyme, both have pronounced effects on IgE-mediated histamine release from SMC but were completely inactive with regard to [DArg0-Hyp3-DPhe7]-bradykinin-stimulated release.	Tetradecanoylphorbol Acetate	141-144	kininogen 1	Homo sapiens	310-320
1703443-6	1991	In addition, accumulation of c-fos mRNA by insulin/dexamethasone/methylisobutylxanthine was enhanced in protein kinase C-depleted cells pretreated with phorbol 12-myristate 13-acetate, indicating that protein kinase C may negatively regulate c-fos expression induced by insulin/dexamethasone/methylisobutylxanthine.	Tetradecanoylphorbol Acetate	152-183	insulin	Homo sapiens	270-277
1845978-4	1991	PMA did not affect surface expression or affinity of the GM-CSF receptor but significantly inhibited GM-CSF- or IL-3-induced tyrosine phosphorylation of p93 and p70.	Tetradecanoylphorbol Acetate	0-3	ubiquitin associated and SH3 domain containing B	Homo sapiens	161-164
1987282-5	1991	In TPA-induced differentiation of HL-60 cells, both fyn and lyn genes, but not fgr gene, were expressed.	Tetradecanoylphorbol Acetate	3-6	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	60-63
1987282-5	1991	In TPA-induced differentiation of HL-60 cells, both fyn and lyn genes, but not fgr gene, were expressed.	Tetradecanoylphorbol Acetate	3-6	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
1985701-3	1991	In uninduced cells, the PKC activators 12-O-tetradecanoyl phorbol-13-acetate (TPA), bryostatin, and 1-oleyl-2-acetylglycerol (OAG) resulted in 15% to 30% decreases in F-actin, whereas FMLP had no effect.	Tetradecanoylphorbol Acetate	39-76	formyl peptide receptor 1	Homo sapiens	184-188
1847302-14	1991	Finally, phorbol myristate acetate augmented the C5aR induction caused by cAMP analog.	Tetradecanoylphorbol Acetate	9-34	complement C5a receptor 1	Homo sapiens	49-53
1847302-14	1991	Finally, phorbol myristate acetate augmented the C5aR induction caused by cAMP analog.	Tetradecanoylphorbol Acetate	9-34	cathelicidin antimicrobial peptide	Homo sapiens	74-78
1987779-12	1991	Pretreatment of cells with the protein kinase C activators phorbol 12-myristate 13-acetate (PMA) and mezerein did not affect [Ca2+]i mobilization or K+ efflux directly but desensitized neurotensin-stimulated efflux by greater than 80%.	Tetradecanoylphorbol Acetate	59-90	neurotensin	Homo sapiens	185-196
1899804-10	1991	We conclude that the action of phorbol myristate acetate is to promote the process of arachidonic acid release by phospholipase A2.	Tetradecanoylphorbol Acetate	31-56	phospholipase A2 group IB	Homo sapiens	114-130
1985909-6	1991	PKC associated to the lipid layer exhibited the expected catalytic property and was fully activated when diacylglycerol or TPA was included in the membrane.	Tetradecanoylphorbol Acetate	123-126	proline rich transmembrane protein 2	Homo sapiens	0-3
1985909-10	1991	They are in line with the suggestion of a major role of Ca2+ in the association (translocation) of PKC to membrane in living cell and suggest that diacylglycerol (and TPA) might activate membrane-associated PKC through local change in the surrounding lipid phase organization.	Tetradecanoylphorbol Acetate	167-170	proline rich transmembrane protein 2	Homo sapiens	99-102
1985909-10	1991	They are in line with the suggestion of a major role of Ca2+ in the association (translocation) of PKC to membrane in living cell and suggest that diacylglycerol (and TPA) might activate membrane-associated PKC through local change in the surrounding lipid phase organization.	Tetradecanoylphorbol Acetate	167-170	proline rich transmembrane protein 2	Homo sapiens	207-210
1986775-9	1991	12-O-tetradecanoylphorbol-13-acetate (TPA) suppresses ERP secretion by THP-1 cells, but it does not modify secretion in macrophages.	Tetradecanoylphorbol Acetate	0-36	GLI family zinc finger 2	Homo sapiens	71-76
1986775-9	1991	12-O-tetradecanoylphorbol-13-acetate (TPA) suppresses ERP secretion by THP-1 cells, but it does not modify secretion in macrophages.	Tetradecanoylphorbol Acetate	38-41	GLI family zinc finger 2	Homo sapiens	71-76
1987779-12	1991	Pretreatment of cells with the protein kinase C activators phorbol 12-myristate 13-acetate (PMA) and mezerein did not affect [Ca2+]i mobilization or K+ efflux directly but desensitized neurotensin-stimulated efflux by greater than 80%.	Tetradecanoylphorbol Acetate	92-95	neurotensin	Homo sapiens	185-196
1846518-3	1991	In contrast, incubation of phorbol myristate acetate (PMA)-stimulated PMNs with holosaturated transferrin at pH 7.4 enhanced the release of Fe2+ from transferrin eightfold in association with marked generation of O2-.	Tetradecanoylphorbol Acetate	27-52	transferrin	Homo sapiens	94-105
1711800-11	1991	These data suggest two possible mechanisms to explain the fibrinogen levels: coagulation is activated, followed by an important fibrinolytic reaction elicited by the large amounts of plasminogen and tPA present in the haemothorax liquid.	Tetradecanoylphorbol Acetate	199-202	fibrinogen beta chain	Homo sapiens	58-68
1846518-3	1991	In contrast, incubation of phorbol myristate acetate (PMA)-stimulated PMNs with holosaturated transferrin at pH 7.4 enhanced the release of Fe2+ from transferrin eightfold in association with marked generation of O2-.	Tetradecanoylphorbol Acetate	27-52	transferrin	Homo sapiens	150-161
1846518-3	1991	In contrast, incubation of phorbol myristate acetate (PMA)-stimulated PMNs with holosaturated transferrin at pH 7.4 enhanced the release of Fe2+ from transferrin eightfold in association with marked generation of O2-.	Tetradecanoylphorbol Acetate	54-57	transferrin	Homo sapiens	94-105
1846518-3	1991	In contrast, incubation of phorbol myristate acetate (PMA)-stimulated PMNs with holosaturated transferrin at pH 7.4 enhanced the release of Fe2+ from transferrin eightfold in association with marked generation of O2-.	Tetradecanoylphorbol Acetate	54-57	transferrin	Homo sapiens	150-161
1760254-4	1991	Utilizing an in vitro phosphorylation assay, we have shown that a calcium-dependent protease, similar to calpain, is involved in the downregulation of membrane-associated PKC induced by anti-immunoglobulin or phorbol 12-myristate 13-acetate (PMA) and ionomycin stimulation of resting B cells.	Tetradecanoylphorbol Acetate	209-240	proline rich transmembrane protein 2	Homo sapiens	171-174
1838253-9	1991	Treatment of cells known to activate the protein kinase C (TPA) and inositol triphosphate pathways has increased the level of beta-MHC mRNA while that of alpha-MHC remained unchanged.	Tetradecanoylphorbol Acetate	59-62	myosin heavy chain 6	Homo sapiens	154-163
1826092-10	1991	Stimulation by fMLP is inhibited by pertussis toxin, unaffected by preventing receptor-triggered cytosolic free calcium [Ca2+]i elevations, and mimicked by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	156-181	formyl peptide receptor 1	Homo sapiens	15-19
1988110-2	1991	The tumor-promoting phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) can enhance this proliferation, partly because of an increase in interleukin 2 (IL-2) production.	Tetradecanoylphorbol Acetate	34-71	interleukin 2	Homo sapiens	143-156
1988110-2	1991	The tumor-promoting phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) can enhance this proliferation, partly because of an increase in interleukin 2 (IL-2) production.	Tetradecanoylphorbol Acetate	34-71	interleukin 2	Homo sapiens	158-162
1988110-2	1991	The tumor-promoting phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) can enhance this proliferation, partly because of an increase in interleukin 2 (IL-2) production.	Tetradecanoylphorbol Acetate	73-76	interleukin 2	Homo sapiens	143-156
1988110-2	1991	The tumor-promoting phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) can enhance this proliferation, partly because of an increase in interleukin 2 (IL-2) production.	Tetradecanoylphorbol Acetate	73-76	interleukin 2	Homo sapiens	158-162
1988110-3	1991	However, if lymphocytes are treated with TPA for 24 h before concanavalin A exposure, IL-2 production and proliferation are depressed.	Tetradecanoylphorbol Acetate	41-44	interleukin 2	Homo sapiens	86-90
1988110-6	1991	However, 12-deoxyphorbol 13-phenylacetate and 12-deoxyphorbol 13-phenylacetate-20-acetate were required at nearly 100-fold higher concentrations than TPA to suppress IL-2 production, suppress mitogenesis, and cause down-regulation of protein kinase C. A comparison of structures indicated that an R group at the 12-position was less important for IL-2 production and mitogenesis than for down-regulation of protein kinase C and the suppression of mitogenesis.	Tetradecanoylphorbol Acetate	150-153	interleukin 2	Homo sapiens	166-170
1988110-6	1991	However, 12-deoxyphorbol 13-phenylacetate and 12-deoxyphorbol 13-phenylacetate-20-acetate were required at nearly 100-fold higher concentrations than TPA to suppress IL-2 production, suppress mitogenesis, and cause down-regulation of protein kinase C. A comparison of structures indicated that an R group at the 12-position was less important for IL-2 production and mitogenesis than for down-regulation of protein kinase C and the suppression of mitogenesis.	Tetradecanoylphorbol Acetate	150-153	interleukin 2	Homo sapiens	347-351
1988168-3	1991	Protein kinase C beta RNA transcripts were induced in neonatal melanocytes cultivated in medium with serum and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	111-147	proline rich transmembrane protein 2	Homo sapiens	0-16
1988168-3	1991	Protein kinase C beta RNA transcripts were induced in neonatal melanocytes cultivated in medium with serum and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	149-152	proline rich transmembrane protein 2	Homo sapiens	0-16
1988168-4	1991	In contrast, PKC alpha and epsilon RNA transcripts were detected in melanocytes cultivated in medium without serum and TPA, but were repressed in melanocytes cultivated in medium with serum and TPA.	Tetradecanoylphorbol Acetate	119-122	protein kinase C alpha	Homo sapiens	13-22
1988168-4	1991	In contrast, PKC alpha and epsilon RNA transcripts were detected in melanocytes cultivated in medium without serum and TPA, but were repressed in melanocytes cultivated in medium with serum and TPA.	Tetradecanoylphorbol Acetate	194-197	protein kinase C alpha	Homo sapiens	13-22
1760254-4	1991	Utilizing an in vitro phosphorylation assay, we have shown that a calcium-dependent protease, similar to calpain, is involved in the downregulation of membrane-associated PKC induced by anti-immunoglobulin or phorbol 12-myristate 13-acetate (PMA) and ionomycin stimulation of resting B cells.	Tetradecanoylphorbol Acetate	242-245	proline rich transmembrane protein 2	Homo sapiens	171-174
2007095-3	1991	The present studies have examined the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the regulation of jun-B gene expression during induction of monocytic differentiation.	Tetradecanoylphorbol Acetate	49-85	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-118
1906437-2	1991	TNF release was stimulated by 10 ng/ml phorbol myristate acetate (PMA), 2 microM calcium ionophore A23187, and 1 microgram/ml lipopolysaccharide (LPS) with synergism seen between PMA and A23187.	Tetradecanoylphorbol Acetate	39-64	tumor necrosis factor	Mus musculus	0-3
2007095-3	1991	The present studies have examined the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the regulation of jun-B gene expression during induction of monocytic differentiation.	Tetradecanoylphorbol Acetate	87-90	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-118
2007095-5	1991	In contrast, treatment with TPA was associated with rapid increases in jun-B mRNA levels that were maximal at 3 h and remained elevated at 48 h. The induction of jun-B expression by TPA in these cells preceded that of the c-jun and c-fos genes.	Tetradecanoylphorbol Acetate	28-31	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-76
2007095-5	1991	In contrast, treatment with TPA was associated with rapid increases in jun-B mRNA levels that were maximal at 3 h and remained elevated at 48 h. The induction of jun-B expression by TPA in these cells preceded that of the c-jun and c-fos genes.	Tetradecanoylphorbol Acetate	182-185	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-76
2007095-6	1991	Similar increases in jun-B transcripts were detectable in TPA-treated THP-1 and U-937 myeloid leukemia cells, although expression of this gene was transient in the more differentiated THP-1 cells.	Tetradecanoylphorbol Acetate	58-61	GLI family zinc finger 2	Homo sapiens	70-75
2007095-9	1991	In contrast, inhibition of protein synthesis was associated with superinduction of TPA-induced jun-B mRNA levels and an increase in stability of this transcript.	Tetradecanoylphorbol Acetate	83-86	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	95-100
1989890-5	1991	After phorbol ester myristate acetate (PMA) treatment, all the cell lines studied expressed or overexpressed IL-6.	Tetradecanoylphorbol Acetate	39-42	interleukin 6	Homo sapiens	109-113
1722684-8	1991	Tetradecanoylphorbol-13 acetate (TPA) and epidermal growth factor (EGF) both of which stimulate thyroid cell growth but inhibit differentiated function, markedly stimulated IGFBP secretion and induced the appearance of a 46 and a 150 kDa IGFBP.	Tetradecanoylphorbol Acetate	33-36	insulin-like growth factor binding protein 2	Rattus norvegicus	173-178
1722684-8	1991	Tetradecanoylphorbol-13 acetate (TPA) and epidermal growth factor (EGF) both of which stimulate thyroid cell growth but inhibit differentiated function, markedly stimulated IGFBP secretion and induced the appearance of a 46 and a 150 kDa IGFBP.	Tetradecanoylphorbol Acetate	33-36	insulin-like growth factor binding protein 2	Rattus norvegicus	238-243
1794450-1	1991	The more interesting features of the effects or PMA on [Ca2+]i and ATP release were the following: 1. preincubation with PMA inhibited thrombin-evoked calcium transients; 2.	Tetradecanoylphorbol Acetate	48-51	coagulation factor II, thrombin	Homo sapiens	135-143
1794450-3	1991	A23187 reversed the inhibitory effect of PMA; 4. subsaturating thrombin concentrations gave results similar to PMA on thrombin-induced calcium and ATP release but not on [Ca2+]i.	Tetradecanoylphorbol Acetate	41-44	coagulation factor II, thrombin	Homo sapiens	63-71
1846595-6	1991	In addition, down-regulation of PK-C by chronic treatment with TPA did not abrogate the okadaic acid-dependent induction.	Tetradecanoylphorbol Acetate	63-66	PKC	Sus scrofa	32-36
1898592-4	1991	In contrast, the mutant cells responded to a similar or greater extent than the parental cells in terms of uPA mRNA induction following treatment with the Ca2+/phospholipid-dependent protein kinase activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	208-239	plasminogen activator, urokinase	Sus scrofa	107-110
1840028-8	1991	In addition, following stimulation with phytohemagglutinin (PHA) and phorbol 12-myristate 13-acetate (or PHA alone) all clones released interferon-gamma and tumour necrosis factor-alpha, but not IL-2.	Tetradecanoylphorbol Acetate	69-100	interferon gamma	Homo sapiens	136-185
1840028-8	1991	In addition, following stimulation with phytohemagglutinin (PHA) and phorbol 12-myristate 13-acetate (or PHA alone) all clones released interferon-gamma and tumour necrosis factor-alpha, but not IL-2.	Tetradecanoylphorbol Acetate	69-100	interleukin 2	Homo sapiens	195-199
1906437-2	1991	TNF release was stimulated by 10 ng/ml phorbol myristate acetate (PMA), 2 microM calcium ionophore A23187, and 1 microgram/ml lipopolysaccharide (LPS) with synergism seen between PMA and A23187.	Tetradecanoylphorbol Acetate	66-69	tumor necrosis factor	Mus musculus	0-3
1906437-2	1991	TNF release was stimulated by 10 ng/ml phorbol myristate acetate (PMA), 2 microM calcium ionophore A23187, and 1 microgram/ml lipopolysaccharide (LPS) with synergism seen between PMA and A23187.	Tetradecanoylphorbol Acetate	179-182	tumor necrosis factor	Mus musculus	0-3
1906437-4	1991	Desensitization of protein kinase C by PMA (1 microgram/ml for 24 h) provided evidence that both PMA- and LPS-stimulated TNF production were protein kinase C-dependent while A23187-stimulated TNF production was not.	Tetradecanoylphorbol Acetate	39-42	tumor necrosis factor	Mus musculus	121-124
1768836-7	1991	Our data also suggest a possible role for the 5-lipoxygenase metabolites in PMA-induced synergism with regard to the release of AA through AA-specific and PMA-sensitive PLA2.	Tetradecanoylphorbol Acetate	76-79	arachidonate 5-lipoxygenase	Homo sapiens	46-60
1985107-6	1991	In two patients with p47-phox deficiency, p67-phox failed to translocate, whereas p47-phox was detected in the particulate fraction of PMA-stimulated neutrophils from two patients deficient in p67-phox.	Tetradecanoylphorbol Acetate	135-138	CD33 molecule	Homo sapiens	193-196
1845803-2	1991	The treatment of macrophages with PMA stimulated the expression of TNF, but not I-A beta, suggesting that the TNF gene is responsive to activators of protein kinase C whereas the I-A beta gene is not.	Tetradecanoylphorbol Acetate	34-37	tumor necrosis factor	Mus musculus	67-70
1845803-2	1991	The treatment of macrophages with PMA stimulated the expression of TNF, but not I-A beta, suggesting that the TNF gene is responsive to activators of protein kinase C whereas the I-A beta gene is not.	Tetradecanoylphorbol Acetate	34-37	tumor necrosis factor	Mus musculus	110-113
1985119-9	1991	Northern blot analysis revealed low-level BL-CAM mRNA expression in unactivated tonsillar B cells, which was rapidly increased after B cell activation with Staphylococcus aureus Cowan strain 1 and phorbol myristate acetate, but not by various cytokines, including interleukin 4 (IL-4), IL-6, and gamma interferon.	Tetradecanoylphorbol Acetate	197-222	CD22 molecule	Homo sapiens	42-48
1768836-7	1991	Our data also suggest a possible role for the 5-lipoxygenase metabolites in PMA-induced synergism with regard to the release of AA through AA-specific and PMA-sensitive PLA2.	Tetradecanoylphorbol Acetate	76-79	phospholipase A2 group IB	Homo sapiens	169-173
1846421-1	1991	Our previous studies have shown that angiotensin II (Ang II) has a dose-dependent biphasic effect on bicarbonate and sodium transport and 4-beta-phorbol-12-myristate-13-acetate can simulate the stimulatory effect of Ang II on Na+/H+ exchange in the proximal convoluted tubules (PCT) of the rat kidney.	Tetradecanoylphorbol Acetate	138-176	angiotensinogen	Rattus norvegicus	37-51
1846421-1	1991	Our previous studies have shown that angiotensin II (Ang II) has a dose-dependent biphasic effect on bicarbonate and sodium transport and 4-beta-phorbol-12-myristate-13-acetate can simulate the stimulatory effect of Ang II on Na+/H+ exchange in the proximal convoluted tubules (PCT) of the rat kidney.	Tetradecanoylphorbol Acetate	138-176	angiotensinogen	Rattus norvegicus	53-59
1899121-5	1991	Treatment of arterial rings with pertussis toxin (100 ng/ml) or with phorbol myristate acetate (PMA, 10(-8) M) inhibited the endothelium-dependent relaxations produced by UK 14,304, an alpha-2 adrenergic agonist, leukotriene C4 or by NaF, a direct activator of G-proteins, but did not affect the endothelium-dependent relaxations produced by bradykinin or by A23187.	Tetradecanoylphorbol Acetate	69-94	kininogen 1	Canis lupus familiaris	342-352
1846421-1	1991	Our previous studies have shown that angiotensin II (Ang II) has a dose-dependent biphasic effect on bicarbonate and sodium transport and 4-beta-phorbol-12-myristate-13-acetate can simulate the stimulatory effect of Ang II on Na+/H+ exchange in the proximal convoluted tubules (PCT) of the rat kidney.	Tetradecanoylphorbol Acetate	138-176	angiotensinogen	Rattus norvegicus	216-222
1899121-5	1991	Treatment of arterial rings with pertussis toxin (100 ng/ml) or with phorbol myristate acetate (PMA, 10(-8) M) inhibited the endothelium-dependent relaxations produced by UK 14,304, an alpha-2 adrenergic agonist, leukotriene C4 or by NaF, a direct activator of G-proteins, but did not affect the endothelium-dependent relaxations produced by bradykinin or by A23187.	Tetradecanoylphorbol Acetate	96-99	kininogen 1	Canis lupus familiaris	342-352
1985214-7	1991	In addition, the NF-kappa B site was protected in DNase assays with HUT-78 cells and 12-O-tetradecanoylphorbol-13-acetate-treated U937 cells.	Tetradecanoylphorbol Acetate	85-121	nuclear factor kappa B subunit 1	Homo sapiens	17-27
1899121-7	1991	Increasing the concentration of PMA (to 3 X 10(-8) and 10(-7) M) caused inhibition of responses to bradykinin.	Tetradecanoylphorbol Acetate	32-35	kininogen 1	Canis lupus familiaris	99-109
2062176-3	1991	Treatment with 10(-8)M phorbol 12-myristate 13-acetate (PMA) reduced the contractile responses to ET-1 in the basilar arteries from control dogs.	Tetradecanoylphorbol Acetate	23-54	endothelin 1	Canis lupus familiaris	98-102
1713637-6	1991	In contrast, IL-1 beta, TNF, and TPA equally stimulated increased levels of M-CSF, GM-CSF, IL-1 beta and IL-6 RNAs.	Tetradecanoylphorbol Acetate	33-36	interleukin 1 beta	Homo sapiens	91-100
1713637-6	1991	In contrast, IL-1 beta, TNF, and TPA equally stimulated increased levels of M-CSF, GM-CSF, IL-1 beta and IL-6 RNAs.	Tetradecanoylphorbol Acetate	33-36	interleukin 6	Homo sapiens	105-109
1904515-2	1991	Between 2 h and 4 h following TPA-treatment U937 cells started to release significant amounts of TNF-alpha which remained detectable until 8-10 days.	Tetradecanoylphorbol Acetate	30-33	tumor necrosis factor	Homo sapiens	97-106
1904515-8	1991	Further investigations on the regulation of cytokine production and release by TPA-differentiated U937 cells revealed that TNF-alpha and IL-1 beta synthesis was not influenced by exogenously added rhTNF-alpha or PGE2, whereas rh gamma-IFN specifically enhanced the IL-1 beta production.	Tetradecanoylphorbol Acetate	79-82	tumor necrosis factor	Homo sapiens	123-132
1904515-8	1991	Further investigations on the regulation of cytokine production and release by TPA-differentiated U937 cells revealed that TNF-alpha and IL-1 beta synthesis was not influenced by exogenously added rhTNF-alpha or PGE2, whereas rh gamma-IFN specifically enhanced the IL-1 beta production.	Tetradecanoylphorbol Acetate	79-82	interleukin 1 beta	Homo sapiens	137-146
2062176-3	1991	Treatment with 10(-8)M phorbol 12-myristate 13-acetate (PMA) reduced the contractile responses to ET-1 in the basilar arteries from control dogs.	Tetradecanoylphorbol Acetate	56-59	endothelin 1	Canis lupus familiaris	98-102
27463048-6	1991	Immunophenotypic analysis showed that TPA induced further differentiation of REH cells along the B-cell lineage as indicated by significant decrease in the expression of CD10, induction of CD11c and increase in the expression of CD22.	Tetradecanoylphorbol Acetate	38-41	membrane metalloendopeptidase	Homo sapiens	170-174
2062176-4	1991	ET-1-induced contractions of the basilar arteries from control dogs were similar to those in strips from SAH dogs by the treatment with 10(-8) M PMA.	Tetradecanoylphorbol Acetate	145-148	endothelin 1	Canis lupus familiaris	0-4
27463048-6	1991	Immunophenotypic analysis showed that TPA induced further differentiation of REH cells along the B-cell lineage as indicated by significant decrease in the expression of CD10, induction of CD11c and increase in the expression of CD22.	Tetradecanoylphorbol Acetate	38-41	CD22 molecule	Homo sapiens	229-233
1865754-3	1991	In addition, a tumor-promoting phorbol ester, phorbol 12-myristate 13-acetate (PMA), inhibited the serum-induced ET-1 production and stimulated PGI2 synthesis in a concentration- and time-dependent manner.	Tetradecanoylphorbol Acetate	46-77	endothelin 1	Homo sapiens	113-117
1907704-5	1991	The secretion of FSH and LH mediated by an activator of protein kinase C, phorbol 12-myristate 13-acetate, was also significantly suppressed by pretreatment with IL-1 beta for 48 hr.	Tetradecanoylphorbol Acetate	74-105	interleukin 1 beta	Rattus norvegicus	162-171
1671790-1	1991	In the present study, we investigated the effects of calmodulin, adenosine 5"-triphosphate (ATP) and pertussis toxin (PT) on phorbol ester (PMA) (a protein kinase C activator) induced inhibition of ANF-stimulated cyclic GMP formation in cells from the human renal cell line, SK-NEP-1.	Tetradecanoylphorbol Acetate	140-143	calmodulin 1	Homo sapiens	53-63
1671790-1	1991	In the present study, we investigated the effects of calmodulin, adenosine 5"-triphosphate (ATP) and pertussis toxin (PT) on phorbol ester (PMA) (a protein kinase C activator) induced inhibition of ANF-stimulated cyclic GMP formation in cells from the human renal cell line, SK-NEP-1.	Tetradecanoylphorbol Acetate	140-143	natriuretic peptide A	Homo sapiens	198-201
1865754-3	1991	In addition, a tumor-promoting phorbol ester, phorbol 12-myristate 13-acetate (PMA), inhibited the serum-induced ET-1 production and stimulated PGI2 synthesis in a concentration- and time-dependent manner.	Tetradecanoylphorbol Acetate	79-82	endothelin 1	Homo sapiens	113-117
1651733-3	1991	Gap-junctional intercellular communication (GJIC) in this cell line decreased within 60 min of 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment and recovered after 24 h. The number of immunofluorescence spots of connexin 43 on IAR 20 was closely related to the change in GJIC induced by TPA.	Tetradecanoylphorbol Acetate	95-131	gap junction protein, alpha 1	Rattus norvegicus	216-227
1845239-0	1991	Interaction of TPA-treated trichomonads with fibronectin-coated substrata.	Tetradecanoylphorbol Acetate	15-18	fibronectin 1	Homo sapiens	45-56
1651733-5	1991	Moreover, connexin 43 protein expression analyzed by western blotting suggests that connexin 43 proteins were still present in TPA-treated cells at a similar level.	Tetradecanoylphorbol Acetate	127-130	gap junction protein, alpha 1	Rattus norvegicus	10-21
1651733-2	1991	The effects of TPA on connexin 43 expression in IAR 20 were investigated using northern blot analysis, western blot analysis, and an immunofluorescence technique.	Tetradecanoylphorbol Acetate	15-18	gap junction protein, alpha 1	Rattus norvegicus	22-33
1651733-5	1991	Moreover, connexin 43 protein expression analyzed by western blotting suggests that connexin 43 proteins were still present in TPA-treated cells at a similar level.	Tetradecanoylphorbol Acetate	127-130	gap junction protein, alpha 1	Rattus norvegicus	84-95
1651733-6	1991	These results suggest that GJIC of these rat liver epithelial cells was mediated by connexin 43 protein and that TPA inhibited GJIC by inhibiting posttranslational processing of connexin 43 proteins, e.g., localization or assembly.	Tetradecanoylphorbol Acetate	113-116	gap junction protein, alpha 1	Rattus norvegicus	178-189
1921761-2	1991	To define its site of action, we determined if CKS-17 conjugated to human serum albumin (CKS-17-HSA) could block the direct activation of lymphocytes by phorbol-12-myristate-13-acetate (PMA) or by a synthetic diacylglycerol, dioctanoylglycerol (DiC8).	Tetradecanoylphorbol Acetate	153-184	albumin	Homo sapiens	74-87
1921761-2	1991	To define its site of action, we determined if CKS-17 conjugated to human serum albumin (CKS-17-HSA) could block the direct activation of lymphocytes by phorbol-12-myristate-13-acetate (PMA) or by a synthetic diacylglycerol, dioctanoylglycerol (DiC8).	Tetradecanoylphorbol Acetate	186-189	albumin	Homo sapiens	74-87
2011132-8	1991	Phorbol 12-myristate 13-acetate induced production of tumor necrosis factor (TNF) in the B-lymphoblastoid cell line RPMI-1788.	Tetradecanoylphorbol Acetate	0-31	tumor necrosis factor	Homo sapiens	54-75
1986224-1	1991	The activation of NF-kappa B-like activities (called NF-kappa B) by tumor necrosis factor alpha (TNF alpha) and the phorbol ester phorbol 12-myristate 13-acetate (PMA) were compared.	Tetradecanoylphorbol Acetate	130-161	nuclear factor kappa B subunit 1	Homo sapiens	18-28
1986224-1	1991	The activation of NF-kappa B-like activities (called NF-kappa B) by tumor necrosis factor alpha (TNF alpha) and the phorbol ester phorbol 12-myristate 13-acetate (PMA) were compared.	Tetradecanoylphorbol Acetate	163-166	nuclear factor kappa B subunit 1	Homo sapiens	18-28
2030746-5	1991	Furthermore, aggregations induced by the calcium ionophore ionomycin and by the protein kinase C-activator 4-beta-phorbol 12-myristate 13-acetate were inhibited by fendiline, although to a smaller degree than the thrombin-induced aggregation.	Tetradecanoylphorbol Acetate	107-145	coagulation factor II, thrombin	Homo sapiens	213-221
2011132-8	1991	Phorbol 12-myristate 13-acetate induced production of tumor necrosis factor (TNF) in the B-lymphoblastoid cell line RPMI-1788.	Tetradecanoylphorbol Acetate	0-31	tumor necrosis factor	Homo sapiens	77-80
2266112-0	1990	The extinction of erythroid genes after tetradecanoylphorbol acetate treatment of erythroleukemic cells correlates with down-regulation of the tissue-specific factors NF-E1 and NF-E2.	Tetradecanoylphorbol Acetate	40-68	GATA binding protein 1	Homo sapiens	167-172
1844247-3	1991	Analysis of 32P-labelled phosphoproteins indicates that R6-PKC cells display increased phosphorylation of a 80/87 kDa protein (designated MARCKS), and after treatment with TPA they display a dramatic prolongation in the phosphorylation and in the cytosolic accumulation of this protein.	Tetradecanoylphorbol Acetate	172-175	proline rich transmembrane protein 2	Homo sapiens	59-62
1844247-8	1991	In response to TPA, the cytosolic levels of all four PKC isozymes were recruited to the membrane fraction.	Tetradecanoylphorbol Acetate	15-18	proline rich transmembrane protein 2	Homo sapiens	53-56
1812285-5	1991	Furthermore, preincubation of endothelial cell with phorbol-12-myristate-13-acetate (PMA) abolished the stimulatory effect of bradykinin on the formation of 1,4,5-IP3 and 1,3,4,5-IP4, but did not affect the longlasting Ca(2+)-influx.	Tetradecanoylphorbol Acetate	52-83	kininogen 1	Homo sapiens	126-136
1812285-5	1991	Furthermore, preincubation of endothelial cell with phorbol-12-myristate-13-acetate (PMA) abolished the stimulatory effect of bradykinin on the formation of 1,4,5-IP3 and 1,3,4,5-IP4, but did not affect the longlasting Ca(2+)-influx.	Tetradecanoylphorbol Acetate	85-88	kininogen 1	Homo sapiens	126-136
1814011-3	1991	Further, it has been shown that tetanus toxin pretreatment attenuates the ability of phorbol myristate acetate to mobilize cytosolic protein kinase C (PKC) in this cell line.	Tetradecanoylphorbol Acetate	85-110	proline rich transmembrane protein 2	Homo sapiens	133-149
1814011-3	1991	Further, it has been shown that tetanus toxin pretreatment attenuates the ability of phorbol myristate acetate to mobilize cytosolic protein kinase C (PKC) in this cell line.	Tetradecanoylphorbol Acetate	85-110	proline rich transmembrane protein 2	Homo sapiens	151-154
2266112-0	1990	The extinction of erythroid genes after tetradecanoylphorbol acetate treatment of erythroleukemic cells correlates with down-regulation of the tissue-specific factors NF-E1 and NF-E2.	Tetradecanoylphorbol Acetate	40-68	nuclear factor, erythroid 2	Homo sapiens	177-182
2266112-2	1990	We show that transcription driven by a -714/+78-base pair DNA fragment of the erythroid promoter of the human porphobilinogen deaminase gene is down-regulated upon TPA treatment of erythroleukemic cells.	Tetradecanoylphorbol Acetate	164-167	hydroxymethylbilane synthase	Homo sapiens	110-135
2266112-4	1990	Kinetics experiments indicated that NF-E2 was down-regulated after 1 h of TPA treatment whereas NF-E1 was down-regulated at the protein and mRNA levels only after 5 h of TPA treatment.	Tetradecanoylphorbol Acetate	74-77	nuclear factor, erythroid 2	Homo sapiens	36-41
2266112-4	1990	Kinetics experiments indicated that NF-E2 was down-regulated after 1 h of TPA treatment whereas NF-E1 was down-regulated at the protein and mRNA levels only after 5 h of TPA treatment.	Tetradecanoylphorbol Acetate	170-173	GATA binding protein 1	Homo sapiens	96-101
2266115-6	1990	Activation of PKC by phorbol myristate acetate causes inhibition of IL-3-mediated growth for the first 72 h of incubation.	Tetradecanoylphorbol Acetate	21-46	interleukin 3	Mus musculus	68-72
2266115-7	1990	The inhibition in IL-3-mediated proliferation gradually lessens with the stages of PKC depletion, which is complete after 72 h. The enhancement in phorbol myristate acetate-treated cells grows as PKC is depleted.	Tetradecanoylphorbol Acetate	147-172	interleukin 3	Mus musculus	18-22
2147939-0	1990	Rapid increase of the human IFN-gamma receptor phosphorylation in response to human IFN-gamma and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	98-123	interferon gamma	Homo sapiens	28-37
1701344-2	1990	When cells were cultured in the presence of 12-O-tetradecanoylphorbol-13-acetate, significant amounts of IL6 were detected in the culture supernatants of Chang liver cells, HLF cells, and HLE cells.	Tetradecanoylphorbol Acetate	44-80	interleukin 6	Homo sapiens	105-108
2250023-6	1990	(iv) Exogenously added 1,2-dimyristoyl-glycerol and 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) again stimulated both the phosphorylation of the 40-kDa protein and 2-deoxyglucose uptake, but in contrast to insulin, they elicited the same level of response in both CHO-R and CHO-Y2 cells.	Tetradecanoylphorbol Acetate	103-106	insulin	Homo sapiens	218-225
2175219-3	1990	In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines.	Tetradecanoylphorbol Acetate	94-119	interleukin 1 beta	Homo sapiens	174-183
2175219-3	1990	In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines.	Tetradecanoylphorbol Acetate	94-119	interleukin 1 beta	Homo sapiens	220-229
2175219-3	1990	In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines.	Tetradecanoylphorbol Acetate	121-124	interleukin 1 beta	Homo sapiens	174-183
2175219-3	1990	In accordance with previous studies, it was observed that a protein kinase C (PKC) activator, phorbol myristate acetate (PMA), was a sufficient stimulus for induction of the IL-1 beta messenger RNA (mRNA) expression and IL-1 beta protein production in both of these cell lines.	Tetradecanoylphorbol Acetate	121-124	interleukin 1 beta	Homo sapiens	220-229
2175219-7	1990	PKC inhibitor, H7, also blocked effectively the PMA plus dbcAMP induced IL-1 beta production, while the protein kinase A (PKA) inhibitor, HA1004, had no effect, suggesting that PKA activation is not involved in the mechanism of action of cAMP in this case.	Tetradecanoylphorbol Acetate	48-51	interleukin 1 beta	Homo sapiens	72-81
2174435-8	1990	In comparison, 12-O-tetradecanoylphorbol-13-acetate (50 ng/ml, 8 x 10(-8) M), which also stimulates collagenase expression strongly (greater than 30-fold), elevated TIMP protein and mRNA levels (2- and 3-fold, respectively) and did not affect MMP-2 expression.	Tetradecanoylphorbol Acetate	15-51	TIMP metallopeptidase inhibitor 1	Homo sapiens	165-169
2129302-3	1990	Phorbol 12-myristate 13-acetate (PMA) and dioctanoyglycerol (diC8) have also been known to stimulate PRL release from pituitary cells, so we showed that these PRL releases were correlated with the activation of protein kinase C, that is, they induced dose-dependent translocation of protein kinase C from the cytosol to the membrane.	Tetradecanoylphorbol Acetate	0-31	prolactin	Rattus norvegicus	101-104
1979029-3	1990	After 15 min of TPA treatment, only 10% of pyroglutamyl peptidase II activity remained.	Tetradecanoylphorbol Acetate	16-19	thyrotropin releasing hormone degrading enzyme	Homo sapiens	43-68
1979029-5	1990	Pretreatment of the cells with the protein kinase C inhibitors H-7 or sphingosine prevented the inactivation of pyroglutamyl peptidase II by TPA.	Tetradecanoylphorbol Acetate	141-144	thyrotropin releasing hormone degrading enzyme	Homo sapiens	112-137
1979029-8	1990	Incubation of TPA-activated Y-79 cell membranes with gamma-[32P]-ATP followed by immunoprecipitation revealed a time-dependent phosphorylation of a 48 kilodalton subunit of pyroglutamyl peptidase II.	Tetradecanoylphorbol Acetate	14-17	thyrotropin releasing hormone degrading enzyme	Homo sapiens	173-198
2129302-3	1990	Phorbol 12-myristate 13-acetate (PMA) and dioctanoyglycerol (diC8) have also been known to stimulate PRL release from pituitary cells, so we showed that these PRL releases were correlated with the activation of protein kinase C, that is, they induced dose-dependent translocation of protein kinase C from the cytosol to the membrane.	Tetradecanoylphorbol Acetate	0-31	prolactin	Rattus norvegicus	159-162
2129302-3	1990	Phorbol 12-myristate 13-acetate (PMA) and dioctanoyglycerol (diC8) have also been known to stimulate PRL release from pituitary cells, so we showed that these PRL releases were correlated with the activation of protein kinase C, that is, they induced dose-dependent translocation of protein kinase C from the cytosol to the membrane.	Tetradecanoylphorbol Acetate	33-36	prolactin	Rattus norvegicus	101-104
2129302-3	1990	Phorbol 12-myristate 13-acetate (PMA) and dioctanoyglycerol (diC8) have also been known to stimulate PRL release from pituitary cells, so we showed that these PRL releases were correlated with the activation of protein kinase C, that is, they induced dose-dependent translocation of protein kinase C from the cytosol to the membrane.	Tetradecanoylphorbol Acetate	33-36	prolactin	Rattus norvegicus	159-162
1964949-7	1990	In contrast, the antiviral effects of IFN-alpha were not blocked by H-7, or by previous down-regulation of PKC by prolonged treatment of HEF cells with TPA.	Tetradecanoylphorbol Acetate	152-155	interferon alpha 1	Homo sapiens	38-47
2126186-3	1990	This was accompanied by a drop in NAD levels of 22% with PMA, 24% with BP and 49% with mezerein, PMA-treated cells showed a decrease in the enzyme activity of 42% with superoxide dismutase (SOD) and catalase (CAT), 18% with butylated hydroxy toluene (BHT), 52% with indomethacin and 32% with 3-aminobenzamine (3AB).	Tetradecanoylphorbol Acetate	97-100	catalase	Homo sapiens	199-207
2126186-3	1990	This was accompanied by a drop in NAD levels of 22% with PMA, 24% with BP and 49% with mezerein, PMA-treated cells showed a decrease in the enzyme activity of 42% with superoxide dismutase (SOD) and catalase (CAT), 18% with butylated hydroxy toluene (BHT), 52% with indomethacin and 32% with 3-aminobenzamine (3AB).	Tetradecanoylphorbol Acetate	97-100	catalase	Homo sapiens	209-212
2176183-5	1990	The phorbol mitogen, 12-tetradecanoylphorbol-13-acetate, differentially increases the levels of these metalloproteinases and TIMP found in retinal pigment epithelium culture medium with stromelysin and the 92-kD type IV collagenase responding most strongly and TIMP actually decreasing in certain cases.	Tetradecanoylphorbol Acetate	21-55	TIMP metallopeptidase inhibitor 1	Homo sapiens	125-129
2176183-5	1990	The phorbol mitogen, 12-tetradecanoylphorbol-13-acetate, differentially increases the levels of these metalloproteinases and TIMP found in retinal pigment epithelium culture medium with stromelysin and the 92-kD type IV collagenase responding most strongly and TIMP actually decreasing in certain cases.	Tetradecanoylphorbol Acetate	21-55	TIMP metallopeptidase inhibitor 1	Homo sapiens	261-265
1701822-6	1990	The secretion of endothelin 1, but not of endothelin 3, from macrophages could be stimulated 6-10-fold by lipopolysaccharide or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	128-153	endothelin 1	Homo sapiens	17-29
1701822-6	1990	The secretion of endothelin 1, but not of endothelin 3, from macrophages could be stimulated 6-10-fold by lipopolysaccharide or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	155-158	endothelin 1	Homo sapiens	17-29
1701822-7	1990	Northern blot analysis of total macrophage RNA using an endothelin 1 cDNA probe revealed induction of endothelin mRNA in PMA-treated macrophages.	Tetradecanoylphorbol Acetate	121-124	endothelin 1	Homo sapiens	56-68
2258638-4	1990	Sixty minutes of preincubation of PMN with 1 microgram/ml TNF alpha or 10 micrograms/ml LPS resulted in similar priming for the respiratory burst elicited by opsonized zymosan, phorbol myristate acetate, zymosan, zymosan-activated serum, aggregated immunoglobulin, and f-met-leu-phe (FMLP) depending on the method of measurement used, i.e., chemiluminescence, production of O2-, and H2O2.	Tetradecanoylphorbol Acetate	177-202	tumor necrosis factor	Homo sapiens	58-67
2174449-7	1990	Treatment of keratinocytes with active phorbol ester (TPA) caused a significant inhibition (50%) of bradykinin-induced IP3 accumulation, suggesting negative regulation of phospholipase C by protein kinase C. Bradykinin also caused a significant elevation in 1,2-diacylglycerol (DAG) content.	Tetradecanoylphorbol Acetate	54-57	kininogen 1	Homo sapiens	100-110
2174449-7	1990	Treatment of keratinocytes with active phorbol ester (TPA) caused a significant inhibition (50%) of bradykinin-induced IP3 accumulation, suggesting negative regulation of phospholipase C by protein kinase C. Bradykinin also caused a significant elevation in 1,2-diacylglycerol (DAG) content.	Tetradecanoylphorbol Acetate	54-57	kininogen 1	Homo sapiens	208-218
2147852-0	1990	Phorbol 12-myristate 13-acetate (TPA) blocks CD3-mediated Ca2+ mobilization in Jurkat T cells independently of protein kinase C activation.	Tetradecanoylphorbol Acetate	0-31	plasminogen activator, tissue type	Homo sapiens	33-36
2175806-3	1990	Strips of dog femoral artery or saphenous vein contracted with phorbol 12-myristate 13-acetate (PMA) were relaxed by 100 microM concentrations of MDL 27,032, as well as by other known inhibitors of PDEs [3-isobutyl-1-methylxanthine and papaverine], myosin light chain kinase (W-7) and protein kinase C (H-7 and polymyxin B).	Tetradecanoylphorbol Acetate	63-94	myosin light chain kinase	Canis lupus familiaris	249-274
2175806-3	1990	Strips of dog femoral artery or saphenous vein contracted with phorbol 12-myristate 13-acetate (PMA) were relaxed by 100 microM concentrations of MDL 27,032, as well as by other known inhibitors of PDEs [3-isobutyl-1-methylxanthine and papaverine], myosin light chain kinase (W-7) and protein kinase C (H-7 and polymyxin B).	Tetradecanoylphorbol Acetate	96-99	myosin light chain kinase	Canis lupus familiaris	249-274
2247845-7	1990	Secondary antibody staining for alpha-actinin, a protein that binds and crosslinks actin, was more prominent after treatment with thyrotropin but decreased after TPA.	Tetradecanoylphorbol Acetate	162-165	actinin alpha 1	Homo sapiens	32-45
2224856-6	1990	We conclude that TPA-induced down-regulation of transferrin binding and internalization does not mediate the subsequent growth arrest and differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	17-20	transferrin	Homo sapiens	48-59
2256925-0	1990	Regulation of creatine phosphokinase B activity by protein kinase C. We previously reported that topical application of 12-o-tetradecanoylphorbol-13-acetate to mouse skin causes phosphorylation of epidermal proteins with molecular weights of 40,000 (p40) and 34,000 (p34).	Tetradecanoylphorbol Acetate	120-156	alpha- and gamma-adaptin binding protein	Mus musculus	267-270
2242429-11	1990	DNA synthesis induced by TPA/Ca2+ was blocked specifically by anti-IL-6 Ab; in contrast, the HCL proliferative response to SAC, TNF, or IL-4 and IL-5 was not inhibited by anti-IL-6 Ab.	Tetradecanoylphorbol Acetate	25-28	interleukin 6	Homo sapiens	67-71
2242429-13	1990	Finally, peroxidase-antiperoxidase staining demonstrated that HCLs are induced by TPA/Ca2+, but not by SAC, to produce intracytoplasmic IL-6.	Tetradecanoylphorbol Acetate	82-85	interleukin 6	Homo sapiens	136-140
2171700-7	1990	First, a polyclonal antibody against u-PA receptor isolated from phorbol myristate acetate (PMA) stimulated U-937 cells reacted with both the 36- and 46-Kd proteins on Western blotting.	Tetradecanoylphorbol Acetate	65-90	plasminogen activator, urokinase	Homo sapiens	37-41
2122915-4	1990	We showed that H7, an inhibitor of PKC, inhibited the PMA-induced u-PA synthesis by LLC-PK1 cells.	Tetradecanoylphorbol Acetate	54-57	plasminogen activator, urokinase	Sus scrofa	66-70
2122915-5	1990	PMA-induced u-PA synthesis was enhanced by eicosatetraynoic acid (ETYA), a competitive inhibitor of both the lipoxygenase and cyclooxygenase pathways and inhibited by nordihydroguaiaretic acid (NDGA), an inhibitor of the lipoxygenase pathway.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase	Sus scrofa	12-16
2122915-7	1990	Two polyunsaturated fatty acids other than ETYA, arachidonic acid and linoleic acid, also potentiated the PMA effect and a lipoxygenase derivative, 12 hydroxyeicosatetraenoic acid (12 HETE), did not modify the basal and PMA-stimulated u-PA syntheses.	Tetradecanoylphorbol Acetate	106-109	plasminogen activator, urokinase	Sus scrofa	235-239
2122915-10	1990	These data suggest that NDGA inhibits PMA-stimulated PKC activity in intact cells leading to a decrease of u-PA mRNA level and u-PA biosynthesis in PMA-stimulated LLC-PK1 cells.	Tetradecanoylphorbol Acetate	38-41	plasminogen activator, urokinase	Sus scrofa	107-111
2122915-10	1990	These data suggest that NDGA inhibits PMA-stimulated PKC activity in intact cells leading to a decrease of u-PA mRNA level and u-PA biosynthesis in PMA-stimulated LLC-PK1 cells.	Tetradecanoylphorbol Acetate	38-41	plasminogen activator, urokinase	Sus scrofa	127-131
2122915-10	1990	These data suggest that NDGA inhibits PMA-stimulated PKC activity in intact cells leading to a decrease of u-PA mRNA level and u-PA biosynthesis in PMA-stimulated LLC-PK1 cells.	Tetradecanoylphorbol Acetate	148-151	plasminogen activator, urokinase	Sus scrofa	107-111
2122915-2	1990	Phorbol myristate acetate (PMA) which mimics the effect of DAG on PKC induces transcriptional activation of the urokinase-type plasminogen activator (u-PA) gene in LLC-PK1 cells.	Tetradecanoylphorbol Acetate	0-25	plasminogen activator, urokinase	Sus scrofa	112-148
2122915-2	1990	Phorbol myristate acetate (PMA) which mimics the effect of DAG on PKC induces transcriptional activation of the urokinase-type plasminogen activator (u-PA) gene in LLC-PK1 cells.	Tetradecanoylphorbol Acetate	0-25	plasminogen activator, urokinase	Sus scrofa	150-154
2122915-2	1990	Phorbol myristate acetate (PMA) which mimics the effect of DAG on PKC induces transcriptional activation of the urokinase-type plasminogen activator (u-PA) gene in LLC-PK1 cells.	Tetradecanoylphorbol Acetate	27-30	plasminogen activator, urokinase	Sus scrofa	112-148
2122915-2	1990	Phorbol myristate acetate (PMA) which mimics the effect of DAG on PKC induces transcriptional activation of the urokinase-type plasminogen activator (u-PA) gene in LLC-PK1 cells.	Tetradecanoylphorbol Acetate	27-30	plasminogen activator, urokinase	Sus scrofa	150-154
1979722-4	1990	Exposure of purified PMN to the secondary granule secretagogue phorbol myristate acetate caused extracellular release of two or three CD15 antigens, which could be purified by immunoprecipitation using antibody M3.	Tetradecanoylphorbol Acetate	63-88	fucosyltransferase 4	Homo sapiens	134-138
2171700-7	1990	First, a polyclonal antibody against u-PA receptor isolated from phorbol myristate acetate (PMA) stimulated U-937 cells reacted with both the 36- and 46-Kd proteins on Western blotting.	Tetradecanoylphorbol Acetate	92-95	plasminogen activator, urokinase	Homo sapiens	37-41
1963797-10	1990	Pretreatment for 10 min with TPA (but not the relatively inactive 4-methoxy TPA) or the non-phorbol protein kinase C stimulator mezerein potently inhibited bradykinin- and histamine-stimulated accumulation of total [3H]-inositol phosphate; inhibition of [3H]-inositol phosphate formation was also seen with 24 h TPA treatment.	Tetradecanoylphorbol Acetate	29-32	kininogen 1	Homo sapiens	156-166
1965139-0	1990	Growth inhibition of a human lymphoma cell line: induction of a transforming growth factor-beta-mediated autocrine negative loop by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	132-157	transforming growth factor beta 1	Homo sapiens	64-95
2146363-13	1990	In addition, PHA alone or in combination with PMA induced tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) (but not IL-2) production by CD3- thymocytes.	Tetradecanoylphorbol Acetate	46-49	tumor necrosis factor	Homo sapiens	58-85
2121373-1	1990	In this study, we investigated the biological effects of N-m-KRTLR using as an in vitro model the induction of the IL-2 receptor and IL-2 secretion by Jurkat cells in response to stimulation with 12-O tetradecanoylphorbol-13-acetate (TPA) plus phytohemagglutinin (PHA) and TPA plus OKT3 mAb.	Tetradecanoylphorbol Acetate	196-232	interleukin 2	Homo sapiens	115-119
2121373-3	1990	Furthermore, N-m-KRTLR inhibited the production and release of IL-2 from cultured Jurkat cells stimulated with TPA plus either PHA or OKT3 mAb.	Tetradecanoylphorbol Acetate	111-114	interleukin 2	Homo sapiens	63-67
2121373-4	1990	Similarly, this peptide significantly inhibited the IL-2 production in normal human peripheral blood mononuclear cells in response to stimulation by TPA and PHA.	Tetradecanoylphorbol Acetate	149-152	interleukin 2	Homo sapiens	52-56
1965139-4	1990	Treatment of the B-cell lines with phorbol 12-myristate 13-acetate (PMA) induced the expression of TGF-beta receptors and inhibited proliferation in all three lines in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	35-66	transforming growth factor beta 1	Homo sapiens	99-107
1965139-4	1990	Treatment of the B-cell lines with phorbol 12-myristate 13-acetate (PMA) induced the expression of TGF-beta receptors and inhibited proliferation in all three lines in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	68-71	transforming growth factor beta 1	Homo sapiens	99-107
1965139-6	1990	A neutralizing antibody to TGF-beta was able to reverse the PMA-induced growth inhibition of the malignant lymphoma cell line, RL, and addition of exogenous TGF-beta reversed the effect of the neutralizing antibody.	Tetradecanoylphorbol Acetate	60-63	transforming growth factor beta 1	Homo sapiens	27-35
1965139-6	1990	A neutralizing antibody to TGF-beta was able to reverse the PMA-induced growth inhibition of the malignant lymphoma cell line, RL, and addition of exogenous TGF-beta reversed the effect of the neutralizing antibody.	Tetradecanoylphorbol Acetate	60-63	transforming growth factor beta 1	Homo sapiens	157-165
2104232-4	1990	Also the NF-kappa B from the human T-cell line Jurkat, activated upon phytohemagglutinin (PHA)/phorbol 12-myristate 13-acetate (PMA/TPA) treatment in vivo or upon deoxycholate treatment in vitro, binds with high affinity to the sequence in the TNF-beta promoter.	Tetradecanoylphorbol Acetate	95-126	nuclear factor kappa B subunit 1	Homo sapiens	9-19
2104232-4	1990	Also the NF-kappa B from the human T-cell line Jurkat, activated upon phytohemagglutinin (PHA)/phorbol 12-myristate 13-acetate (PMA/TPA) treatment in vivo or upon deoxycholate treatment in vitro, binds with high affinity to the sequence in the TNF-beta promoter.	Tetradecanoylphorbol Acetate	128-131	nuclear factor kappa B subunit 1	Homo sapiens	9-19
2104232-4	1990	Also the NF-kappa B from the human T-cell line Jurkat, activated upon phytohemagglutinin (PHA)/phorbol 12-myristate 13-acetate (PMA/TPA) treatment in vivo or upon deoxycholate treatment in vitro, binds with high affinity to the sequence in the TNF-beta promoter.	Tetradecanoylphorbol Acetate	132-135	nuclear factor kappa B subunit 1	Homo sapiens	9-19
2146363-13	1990	In addition, PHA alone or in combination with PMA induced tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) (but not IL-2) production by CD3- thymocytes.	Tetradecanoylphorbol Acetate	46-49	tumor necrosis factor	Homo sapiens	87-96
2213017-4	1990	The protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulates the synthesis of both uPA and PAI-1, resulting in a final increase in the plasmin-generating capacity of neuronal cell cultures.	Tetradecanoylphorbol Acetate	37-73	plasminogen activator, urokinase	Homo sapiens	113-116
2146363-13	1990	In addition, PHA alone or in combination with PMA induced tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) (but not IL-2) production by CD3- thymocytes.	Tetradecanoylphorbol Acetate	46-49	interferon gamma	Homo sapiens	102-129
2213017-4	1990	The protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulates the synthesis of both uPA and PAI-1, resulting in a final increase in the plasmin-generating capacity of neuronal cell cultures.	Tetradecanoylphorbol Acetate	75-78	plasminogen activator, urokinase	Homo sapiens	113-116
2146363-13	1990	In addition, PHA alone or in combination with PMA induced tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) (but not IL-2) production by CD3- thymocytes.	Tetradecanoylphorbol Acetate	46-49	interleukin 2	Homo sapiens	140-144
1700277-7	1990	TPA plus A23187 transiently increased CAT activity before repressing it, reflecting the complex actions of angiotensin II in vivo.	Tetradecanoylphorbol Acetate	0-3	angiotensinogen	Homo sapiens	107-121
1700277-10	1990	Thus, the human gene for P450scc is repressed by TPA plus A23187 by mechanisms and sequences independent of those that mediate induction by cAMP.	Tetradecanoylphorbol Acetate	49-52	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	25-32
1700277-0	1990	Human P450scc gene transcription is induced by cyclic AMP and repressed by 12-O-tetradecanoylphorbol-13-acetate and A23187 through independent cis elements.	Tetradecanoylphorbol Acetate	75-111	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	6-13
2173567-0	1990	TPA inhibits insulin stimulated PIP hydrolysis in fat cell membranes: evidence for modulation of insulin dependent phospholipase C by proteinkinase C. Proteinkinase-C (PKC) stimulating phorbolesters induce in vitro insulin resistance of isolated adipocytes.	Tetradecanoylphorbol Acetate	0-3	insulin	Homo sapiens	13-20
2233728-1	1990	12-Tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of U937 promonocytes leads to a 30-fold increase in transforming growth factor beta 1 (TGF-beta 1) gene expression, and this effect results from a stabilized mRNA.	Tetradecanoylphorbol Acetate	0-34	transforming growth factor beta 1	Homo sapiens	117-150
2233728-1	1990	12-Tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of U937 promonocytes leads to a 30-fold increase in transforming growth factor beta 1 (TGF-beta 1) gene expression, and this effect results from a stabilized mRNA.	Tetradecanoylphorbol Acetate	0-34	transforming growth factor beta 1	Homo sapiens	152-162
2233728-1	1990	12-Tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of U937 promonocytes leads to a 30-fold increase in transforming growth factor beta 1 (TGF-beta 1) gene expression, and this effect results from a stabilized mRNA.	Tetradecanoylphorbol Acetate	36-39	transforming growth factor beta 1	Homo sapiens	117-150
2233728-1	1990	12-Tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of U937 promonocytes leads to a 30-fold increase in transforming growth factor beta 1 (TGF-beta 1) gene expression, and this effect results from a stabilized mRNA.	Tetradecanoylphorbol Acetate	36-39	transforming growth factor beta 1	Homo sapiens	152-162
2233728-3	1990	Related studies in vitro showed that postnuclear extracts of U937 promonocytes contain a ribonuclease system that degrades TGF-beta 1 mRNA selectively and that this system is completely blocked by prior treatment of the cells with TPA.	Tetradecanoylphorbol Acetate	231-234	transforming growth factor beta 1	Homo sapiens	123-133
2175060-10	1990	Only 53% of TIL clones released IL-2 in response to PHA + TPA stimulation, whereas 68% of PBL-derived clones were IL-2 producers.	Tetradecanoylphorbol Acetate	58-61	interleukin 2	Homo sapiens	32-36
2126340-0	1990	Stimulation of TPA-responsive element activity by a cooperative action of insulin and estrogen in human breast cancer cells.	Tetradecanoylphorbol Acetate	15-18	insulin	Homo sapiens	74-81
2173567-6	1990	When plasma membranes from phorbolester (TPA) treated fat cells were used, this insulin stimulated phospholipase C activity was suppressed, provided, membranes have been prepared in a buffer containing serine phosphatase inhibitors.	Tetradecanoylphorbol Acetate	41-44	insulin	Homo sapiens	80-87
2173567-7	1990	These data suggest that fat cell membranes contain an insulin dependent phospholipase C which is inhibited by TPA most likely via serine phosphorylation through proteinkinase C.	Tetradecanoylphorbol Acetate	110-113	insulin	Homo sapiens	54-61
2120135-8	1990	The induction of poly-ADP-ribose synthesis by PMA and BP appears to be mediated at least in part by active oxygen species, as they induced an increase in superoxide anions and anti-oxidants prevented the increase of poly-ADPRT activity to varying extents.	Tetradecanoylphorbol Acetate	46-49	poly(ADP-ribose) polymerase 1	Homo sapiens	221-226
1976698-2	1990	In response to diacylglycerol (DAG) analogues such as PMA and 1,2-dioctanoyl-sn-glycerol, a prolonged cellular aggregation occurs that is associated with intense phosphorylation of the CD18 beta-chain.	Tetradecanoylphorbol Acetate	54-57	integrin subunit beta 2	Homo sapiens	185-189
2170520-4	1990	Over a 6-day period of induction the rank order of the ability of these agents to induce expression of PMA-stimulated superoxide production was: IFN-gamma greater than 1,25(OH)2D3 greater than retinoic acid greater than DMSO.	Tetradecanoylphorbol Acetate	103-106	interferon gamma	Homo sapiens	145-154
2171676-1	1990	Neutrophils exhibit an intense phosphorylation of a 47 kDa protein and release large quantities of superoxide (O2-) upon stimulation with phorbol 12-myristate 13-acetate (PMA) or fMet-Leu-Phe (fMLP).	Tetradecanoylphorbol Acetate	138-169	formyl peptide receptor 1	Homo sapiens	193-197
1698820-3	1990	After exposure to LPS (10 micrograms/ml) and 12-O-tetradecanoylphorbol-13-acetate (TPA, 100 nM) for 12 h, these HIV-1-infected monoblasts accumulated 8-15-fold greater levels of IL-1 beta RNA as compared with their HIV-1-uninfected counterparts that were similarly stimulated.	Tetradecanoylphorbol Acetate	45-81	interleukin 1 beta	Homo sapiens	178-187
1698820-3	1990	After exposure to LPS (10 micrograms/ml) and 12-O-tetradecanoylphorbol-13-acetate (TPA, 100 nM) for 12 h, these HIV-1-infected monoblasts accumulated 8-15-fold greater levels of IL-1 beta RNA as compared with their HIV-1-uninfected counterparts that were similarly stimulated.	Tetradecanoylphorbol Acetate	83-86	interleukin 1 beta	Homo sapiens	178-187
1698820-6	1990	Time-course experiments showed that the maximal levels of IL-1 beta RNA occurred at 12 and 24 h after LPS and TPA stimulation of the HIV-1-infected and uninfected U937 cells, respectively.	Tetradecanoylphorbol Acetate	110-113	interleukin 1 beta	Homo sapiens	58-67
1698820-7	1990	Studies of stability of RNA using actinomycin D showed that IL-1 beta RNA was equally stable in infected and uninfected U937 cells after their stimulation with TPA and LPS.	Tetradecanoylphorbol Acetate	160-163	interleukin 1 beta	Homo sapiens	60-69
1979609-9	1990	Protein kinase C activation by 1 microM mucosal phorbol myristate acetate (PMA) induced submaximal bladder Pfte (0.015 cm/s) and endosome Pf (0.022 cm/s) in the absence of VP, but had little effect on maximal Pfte and endosome Pf induced by VP.	Tetradecanoylphorbol Acetate	48-73	arginine vasopressin	Homo sapiens	241-243
1979609-9	1990	Protein kinase C activation by 1 microM mucosal phorbol myristate acetate (PMA) induced submaximal bladder Pfte (0.015 cm/s) and endosome Pf (0.022 cm/s) in the absence of VP, but had little effect on maximal Pfte and endosome Pf induced by VP.	Tetradecanoylphorbol Acetate	75-78	arginine vasopressin	Homo sapiens	172-174
1979609-9	1990	Protein kinase C activation by 1 microM mucosal phorbol myristate acetate (PMA) induced submaximal bladder Pfte (0.015 cm/s) and endosome Pf (0.022 cm/s) in the absence of VP, but had little effect on maximal Pfte and endosome Pf induced by VP.	Tetradecanoylphorbol Acetate	75-78	arginine vasopressin	Homo sapiens	241-243
2118969-9	1990	In contrast, PMA-induced IL-6 gene transcription was not affected by rIL-4.	Tetradecanoylphorbol Acetate	13-16	interleukin 6	Homo sapiens	25-29
2204815-1	1990	The gene encoding interleukin-2 (IL-2) contains a sequence 52 to 326 nucleotides upstream of its transcriptional initiation site that promotes transcription in T cells that have been activated by costimulation with tetradecanoyl phorbol myristyl acetate (TPA) and phytohemagglutinin (PHA).	Tetradecanoylphorbol Acetate	255-258	interleukin 2	Homo sapiens	18-31
2204815-1	1990	The gene encoding interleukin-2 (IL-2) contains a sequence 52 to 326 nucleotides upstream of its transcriptional initiation site that promotes transcription in T cells that have been activated by costimulation with tetradecanoyl phorbol myristyl acetate (TPA) and phytohemagglutinin (PHA).	Tetradecanoylphorbol Acetate	255-258	interleukin 2	Homo sapiens	33-37
2204815-3	1990	Each site in the IL-2 enhancer that bound Oct-1 in vitro was also required to achieve a maximal transcriptional response to TPA plus PHA in vivo.	Tetradecanoylphorbol Acetate	124-127	interleukin 2	Homo sapiens	17-21
2219271-5	1990	Cyclosporine also inhibits by 66% the insulin secretory response to 100 nmol/L phorbol 12-myristate 13-acetate, suggesting that either cyclosporine interferes with phorbol ester action on beta cells or the action site is located beyond the protein kinase C activation.	Tetradecanoylphorbol Acetate	79-110	insulin	Homo sapiens	38-45
2119586-6	1990	In TPA-differentiated cells, dexamethasone decreased the activities of two enzymes essential for prostanoid synthesis, cyclooxygenase and phospholipase A2, by 60-70% and 30%, respectively.	Tetradecanoylphorbol Acetate	3-6	phospholipase A2 group IB	Homo sapiens	138-154
2393871-5	1990	The ability of catalase, the enzyme that detoxifies hydrogen peroxide, to suppress DCFH oxidation to control levels suggested that intracellular hydrogen peroxide was responsible for the enhanced rate of DCFH oxidation in epidermal cells isolated from TPA-treated mice.	Tetradecanoylphorbol Acetate	252-255	catalase	Mus musculus	15-23
2401353-1	1990	Epidermal growth factor receptor gene expression in response to the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) was analyzed in the A549 human lung adenocarcinoma cell line using DNA transfection.	Tetradecanoylphorbol Acetate	136-139	epidermal growth factor receptor	Homo sapiens	0-32
2393720-7	1990	T beta 4 messenger RNA increased in MOLT-3 during differentiation by 12-O-tetradecanoylphorbol-13-acetate (TPA), in HL60 cells induced by TPA or dimethylsulfoxide and K562 cells stimulated by cytosine arabinoside or hemin.	Tetradecanoylphorbol Acetate	69-105	thymosin beta 4 X-linked	Homo sapiens	0-8
2393720-7	1990	T beta 4 messenger RNA increased in MOLT-3 during differentiation by 12-O-tetradecanoylphorbol-13-acetate (TPA), in HL60 cells induced by TPA or dimethylsulfoxide and K562 cells stimulated by cytosine arabinoside or hemin.	Tetradecanoylphorbol Acetate	107-110	thymosin beta 4 X-linked	Homo sapiens	0-8
2393720-7	1990	T beta 4 messenger RNA increased in MOLT-3 during differentiation by 12-O-tetradecanoylphorbol-13-acetate (TPA), in HL60 cells induced by TPA or dimethylsulfoxide and K562 cells stimulated by cytosine arabinoside or hemin.	Tetradecanoylphorbol Acetate	138-141	thymosin beta 4 X-linked	Homo sapiens	0-8
2124528-4	1990	The aCL activity was slightly inhibited by fresh MNC, and was definitely inhibited by thrombin-activated platelets and polymorphonuclear cells (PMN) stimulated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	165-196	coagulation factor II, thrombin	Homo sapiens	86-94
2124528-4	1990	The aCL activity was slightly inhibited by fresh MNC, and was definitely inhibited by thrombin-activated platelets and polymorphonuclear cells (PMN) stimulated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	198-201	coagulation factor II, thrombin	Homo sapiens	86-94
2176187-4	1990	Phorbol myristate acetate (PMA) stimulated protein phosphorylation and caused a significant decrease in surface display of CD4.	Tetradecanoylphorbol Acetate	0-25	CD4 molecule	Homo sapiens	123-126
2176187-4	1990	Phorbol myristate acetate (PMA) stimulated protein phosphorylation and caused a significant decrease in surface display of CD4.	Tetradecanoylphorbol Acetate	27-30	CD4 molecule	Homo sapiens	123-126
2391360-7	1990	L-plastin is found in only normal or transformed leukocytes where it becomes phosphorylated in response to IL 1 or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	115-140	lymphocyte cytosolic protein 1	Homo sapiens	0-9
2401848-8	1990	Exposure of cells to phorbol myristate acetate resulted in a decrease in cell surface transferrin receptor and a decrease in the release of soluble transferrin receptor.	Tetradecanoylphorbol Acetate	21-46	transferrin	Homo sapiens	86-97
2401848-8	1990	Exposure of cells to phorbol myristate acetate resulted in a decrease in cell surface transferrin receptor and a decrease in the release of soluble transferrin receptor.	Tetradecanoylphorbol Acetate	21-46	transferrin	Homo sapiens	148-159
2176245-3	1990	The results demonstrated that there were three distinct mRNAs for ET and that TPA-responsive element, mRNA stabilizing sequence, motifs for binding site of nuclear factor 1 and acute phase reactant regulatory elements were recognized in preproform ET-1 gene.	Tetradecanoylphorbol Acetate	78-81	endothelin 1	Homo sapiens	248-252
2203949-9	1990	Down regulation of PKC activity by preincubation of KCs with phorbol myristate acetate (PMA, a direct activator of PKC) also resulted in significantly reduced TNF release after LPS stimulation.	Tetradecanoylphorbol Acetate	61-86	tumor necrosis factor	Mus musculus	159-162
2203949-9	1990	Down regulation of PKC activity by preincubation of KCs with phorbol myristate acetate (PMA, a direct activator of PKC) also resulted in significantly reduced TNF release after LPS stimulation.	Tetradecanoylphorbol Acetate	88-91	tumor necrosis factor	Mus musculus	159-162
2170389-5	1990	Addition of the protein kinase C inhibitor staurosporine or down-regulation of protein kinase C by prolonged incubation with phorbol 12-myristate 13-acetate partially reduced the effects of angiotensin II and alpha-thrombin and completely blunted the phorbol 12-myristate 13-acetate-induced stimulation of Na+/K+/Cl- cotransport but did not affect EGF-induced stimulation.	Tetradecanoylphorbol Acetate	125-156	angiotensinogen	Rattus norvegicus	190-204
2170389-5	1990	Addition of the protein kinase C inhibitor staurosporine or down-regulation of protein kinase C by prolonged incubation with phorbol 12-myristate 13-acetate partially reduced the effects of angiotensin II and alpha-thrombin and completely blunted the phorbol 12-myristate 13-acetate-induced stimulation of Na+/K+/Cl- cotransport but did not affect EGF-induced stimulation.	Tetradecanoylphorbol Acetate	125-156	coagulation factor II	Rattus norvegicus	215-223
2170389-5	1990	Addition of the protein kinase C inhibitor staurosporine or down-regulation of protein kinase C by prolonged incubation with phorbol 12-myristate 13-acetate partially reduced the effects of angiotensin II and alpha-thrombin and completely blunted the phorbol 12-myristate 13-acetate-induced stimulation of Na+/K+/Cl- cotransport but did not affect EGF-induced stimulation.	Tetradecanoylphorbol Acetate	251-282	angiotensinogen	Rattus norvegicus	190-204
2171676-1	1990	Neutrophils exhibit an intense phosphorylation of a 47 kDa protein and release large quantities of superoxide (O2-) upon stimulation with phorbol 12-myristate 13-acetate (PMA) or fMet-Leu-Phe (fMLP).	Tetradecanoylphorbol Acetate	171-174	formyl peptide receptor 1	Homo sapiens	193-197
2171676-7	1990	In this paper, we now report that while neutrophils treated with 15 nM staurosporine and PMA release little O2-, cells in the presence of these compounds can be stimulated to release near normal quantities of O2- by the subsequent addition of fMLP.	Tetradecanoylphorbol Acetate	89-92	formyl peptide receptor 1	Homo sapiens	243-247
2121048-7	1990	BK increased PGE2 production in PMA-treated cells, suggesting a protein kinase C-independent mechanism of action as well.	Tetradecanoylphorbol Acetate	32-35	kininogen 1	Canis lupus familiaris	0-2
2171499-3	1990	Both the Ca2+ ionophore ionomycin and the tumour promotor tetradecanoylphorbol acetate (TPA), added shortly before EGF, inhibit EGF receptor protein tyrosine kinase activity in intact cells.	Tetradecanoylphorbol Acetate	58-86	epidermal growth factor receptor	Homo sapiens	128-140
2171499-3	1990	Both the Ca2+ ionophore ionomycin and the tumour promotor tetradecanoylphorbol acetate (TPA), added shortly before EGF, inhibit EGF receptor protein tyrosine kinase activity in intact cells.	Tetradecanoylphorbol Acetate	88-91	epidermal growth factor receptor	Homo sapiens	128-140
2133218-1	1990	In this work, fibrinogen evolution was analysed by testing the reactivity of fibrinogen from different species with monoclonal antibodies against human fibrinogen fragment D. One epitope concerning the fibrin polymerization site "a" and two epitopes responsible for tPA binding to fibrin were conserved in all mammalian fibrogens tested but not in crab coagulogen or pleurodella fibrinogen.	Tetradecanoylphorbol Acetate	266-269	fibrinogen beta chain	Homo sapiens	14-24
2212953-5	1990	Moreover, crosslinking native or truncated A2 or B27 induced IL-2 production upon co-stimulation with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	102-127	melanocortin 2 receptor accessory protein	Homo sapiens	49-52
2212953-5	1990	Moreover, crosslinking native or truncated A2 or B27 induced IL-2 production upon co-stimulation with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	102-127	interleukin 2	Homo sapiens	61-65
2398390-3	1990	The administration of the PKC-activating phorbol esters 4-beta-phorbol-12,13-dibutyrate (PDB) and phorbol-12-myristate-13-acetate (PMA) resulted in a dose-related inhibition of growth of human glioma cell lines in vitro as measured by 3H-thymidine uptake.	Tetradecanoylphorbol Acetate	98-129	proline rich transmembrane protein 2	Homo sapiens	26-29
2398390-3	1990	The administration of the PKC-activating phorbol esters 4-beta-phorbol-12,13-dibutyrate (PDB) and phorbol-12-myristate-13-acetate (PMA) resulted in a dose-related inhibition of growth of human glioma cell lines in vitro as measured by 3H-thymidine uptake.	Tetradecanoylphorbol Acetate	131-134	proline rich transmembrane protein 2	Homo sapiens	26-29
2222456-8	1990	Interestingly, TPA activated PLD in intact cells but not in lysates or subcellular fractions.	Tetradecanoylphorbol Acetate	15-18	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	29-32
2222456-9	1990	These observations suggest that stimulation of PLD-catalyzed PEt synthesis by TPA is not solely mediated through PKC activation.	Tetradecanoylphorbol Acetate	78-81	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	47-50
2144778-8	1990	Furthermore, dexamethasone, an inhibitor of phospholipase A2 activity, blocked TPA-induced increases in arachidonic acid release.	Tetradecanoylphorbol Acetate	79-82	phospholipase A2 group IB	Homo sapiens	44-60
2168414-4	1990	Furthermore, when thrombin (0.1 unit/ml) or the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) had raised pHi from 7.13 +/- 0.05 to 7.35 +/- 0.07 (n = 30), addition of NaF (2.5-10 mM) rapidly restored pHi to values found before stimulation.	Tetradecanoylphorbol Acetate	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	178-181
2168414-5	1990	Conversely, preincubation of platelets with low concentrations of NaF (2.5 mM) completely prevented alkalinization in response to thrombin or TPA.	Tetradecanoylphorbol Acetate	142-145	C-X-C motif chemokine ligand 8	Homo sapiens	66-69
2168677-6	1990	Furthermore, PMA (4 x 10(-5) M) and DiC8 (5 x 10(-5) M) inhibited vasopressin (50 mU/ml)-stimulated cAMP accumulation.	Tetradecanoylphorbol Acetate	13-16	arginine vasopressin	Homo sapiens	66-77
2166625-8	1990	Additive effects of IL-4 and IFN were on the other hand seen on HLA-DR and HLA-DQ expression as well as on O2- production in response to stimulation with phorbol ester (PMA).	Tetradecanoylphorbol Acetate	169-172	interleukin 4	Homo sapiens	20-32
2386936-2	1990	Staurosporine enhanced the decrease in the number of viable cells caused by TNF treatment for 3 days (1 ng/ml of TNF, 43% decrease; 1 ng/ml of TNF + 20 nM staurosporine, 94%), whereas the cytotoxic action on that cell line induced by 10 ng/ml of 12-O-tetradecanoylphorbol-13-acetate (TPA), which was known to be an activator of PKC, was partially inhibited by staurosporine.	Tetradecanoylphorbol Acetate	246-282	tumor necrosis factor	Homo sapiens	76-79
2386936-2	1990	Staurosporine enhanced the decrease in the number of viable cells caused by TNF treatment for 3 days (1 ng/ml of TNF, 43% decrease; 1 ng/ml of TNF + 20 nM staurosporine, 94%), whereas the cytotoxic action on that cell line induced by 10 ng/ml of 12-O-tetradecanoylphorbol-13-acetate (TPA), which was known to be an activator of PKC, was partially inhibited by staurosporine.	Tetradecanoylphorbol Acetate	284-287	tumor necrosis factor	Homo sapiens	76-79
1981755-4	1990	Like TPA, both C and CCK, but not H, stimulated the Ca+2-sensitive particulate PK C.	Tetradecanoylphorbol Acetate	5-8	proline rich transmembrane protein 2	Homo sapiens	79-83
2177654-3	1990	The rate of induction by okadaic acid was delayed compared to the induction of NF-kappa B by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	93-118	nuclear factor kappa B subunit 1	Homo sapiens	79-89
2177654-3	1990	The rate of induction by okadaic acid was delayed compared to the induction of NF-kappa B by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	120-123	nuclear factor kappa B subunit 1	Homo sapiens	79-89
2402510-3	1990	Addition of phorbol 12-myristate 13-acetate resulted in increased flagellar motility that was blocked by known PKC inhibitors such as sphingosine, staurosporine, and 1-(5-isoquinoylinylsulfonyl)-2-methylpiperazine.	Tetradecanoylphorbol Acetate	12-43	proline rich transmembrane protein 2	Homo sapiens	111-114
2168181-2	1990	TGF-beta 1 (2.5 to 10 pM) alone could not inhibit the growth of Mahlavu cells, whereas in the presence of 12-O-tetradecanoyl phorbol 13-acetate (TPA) at 1 ng/ml, TGF-beta 1 could suppress their growth in a dose-dependent manner.	Tetradecanoylphorbol Acetate	106-143	transforming growth factor beta 1	Homo sapiens	162-172
2167556-1	1990	We have previously shown that 12-O-tetradecanoylphorbol-13-acetate (TPA) which activates expression of the latent genome of the Epstein-Barr virus (EBV) in Burkitt lymphoma cells induces the synthesis of two cellular anti-EBNA-1 competitor proteins, anti-EBNA-1.1 and anti-EBNA-1.2.	Tetradecanoylphorbol Acetate	30-66	EBNA-1	Human gammaherpesvirus 4	222-228
2167556-1	1990	We have previously shown that 12-O-tetradecanoylphorbol-13-acetate (TPA) which activates expression of the latent genome of the Epstein-Barr virus (EBV) in Burkitt lymphoma cells induces the synthesis of two cellular anti-EBNA-1 competitor proteins, anti-EBNA-1.1 and anti-EBNA-1.2.	Tetradecanoylphorbol Acetate	30-66	EBNA-1	Human gammaherpesvirus 4	255-261
2167556-1	1990	We have previously shown that 12-O-tetradecanoylphorbol-13-acetate (TPA) which activates expression of the latent genome of the Epstein-Barr virus (EBV) in Burkitt lymphoma cells induces the synthesis of two cellular anti-EBNA-1 competitor proteins, anti-EBNA-1.1 and anti-EBNA-1.2.	Tetradecanoylphorbol Acetate	30-66	EBNA-1	Human gammaherpesvirus 4	255-261
2167556-1	1990	We have previously shown that 12-O-tetradecanoylphorbol-13-acetate (TPA) which activates expression of the latent genome of the Epstein-Barr virus (EBV) in Burkitt lymphoma cells induces the synthesis of two cellular anti-EBNA-1 competitor proteins, anti-EBNA-1.1 and anti-EBNA-1.2.	Tetradecanoylphorbol Acetate	68-71	EBNA-1	Human gammaherpesvirus 4	222-228
2167556-1	1990	We have previously shown that 12-O-tetradecanoylphorbol-13-acetate (TPA) which activates expression of the latent genome of the Epstein-Barr virus (EBV) in Burkitt lymphoma cells induces the synthesis of two cellular anti-EBNA-1 competitor proteins, anti-EBNA-1.1 and anti-EBNA-1.2.	Tetradecanoylphorbol Acetate	68-71	EBNA-1	Human gammaherpesvirus 4	255-261
2167556-1	1990	We have previously shown that 12-O-tetradecanoylphorbol-13-acetate (TPA) which activates expression of the latent genome of the Epstein-Barr virus (EBV) in Burkitt lymphoma cells induces the synthesis of two cellular anti-EBNA-1 competitor proteins, anti-EBNA-1.1 and anti-EBNA-1.2.	Tetradecanoylphorbol Acetate	68-71	EBNA-1	Human gammaherpesvirus 4	255-261
2168181-4	1990	The TGF-beta 1 inhibition induced by TPA in Mahlavu cells could not be cancelled by addition of protein kinase C inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) (10 microM) or staurosporin (1 nM).	Tetradecanoylphorbol Acetate	37-40	transforming growth factor beta 1	Homo sapiens	4-14
2168181-5	1990	Thus, TPA could induce TGF-beta 1 inhibition of cell growth in Mahlavu cells which did not respond to TGF-beta 1 alone, and activation of protein kinase C does not seem to be behind this TPA action.	Tetradecanoylphorbol Acetate	6-9	transforming growth factor beta 1	Homo sapiens	23-33
2390085-0	1990	Phorbol-12-myristate-13-acetate activation of phospholipase D in human neutrophils leads to the production of phosphatides and diglycerides.	Tetradecanoylphorbol Acetate	0-31	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	46-61
2390085-1	1990	The contribution of phospholipase D (PLD) to the production of phosphatides (PA) and diglycerides (DG) in phorbol-12-myristate-13-acetate (PMA)-stimulated human neutrophils was studied.	Tetradecanoylphorbol Acetate	106-137	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	20-35
2390085-1	1990	The contribution of phospholipase D (PLD) to the production of phosphatides (PA) and diglycerides (DG) in phorbol-12-myristate-13-acetate (PMA)-stimulated human neutrophils was studied.	Tetradecanoylphorbol Acetate	106-137	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	37-40
2390085-1	1990	The contribution of phospholipase D (PLD) to the production of phosphatides (PA) and diglycerides (DG) in phorbol-12-myristate-13-acetate (PMA)-stimulated human neutrophils was studied.	Tetradecanoylphorbol Acetate	139-142	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	20-35
2390085-1	1990	The contribution of phospholipase D (PLD) to the production of phosphatides (PA) and diglycerides (DG) in phorbol-12-myristate-13-acetate (PMA)-stimulated human neutrophils was studied.	Tetradecanoylphorbol Acetate	139-142	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	37-40
2390085-7	1990	The results of this study demonstrate that PMA activates PLD in neutrophils leading to the generation of PA and that the bulk of the DG mass accumulation is derived from the sequential actions of PLD and PPH on PC.	Tetradecanoylphorbol Acetate	43-46	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	57-60
2379149-2	1990	In the present study experiments were undertaken with the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), an agent known to decrease EGF-R binding, in order to further define the relationship between changes in EGF-R binding and changes in growth rates in 10 human breast cancer cell lines.	Tetradecanoylphorbol Acetate	73-110	epidermal growth factor receptor	Homo sapiens	145-150
2379149-2	1990	In the present study experiments were undertaken with the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), an agent known to decrease EGF-R binding, in order to further define the relationship between changes in EGF-R binding and changes in growth rates in 10 human breast cancer cell lines.	Tetradecanoylphorbol Acetate	73-110	epidermal growth factor receptor	Homo sapiens	223-228
2379149-2	1990	In the present study experiments were undertaken with the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), an agent known to decrease EGF-R binding, in order to further define the relationship between changes in EGF-R binding and changes in growth rates in 10 human breast cancer cell lines.	Tetradecanoylphorbol Acetate	112-115	epidermal growth factor receptor	Homo sapiens	145-150
2379149-2	1990	In the present study experiments were undertaken with the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), an agent known to decrease EGF-R binding, in order to further define the relationship between changes in EGF-R binding and changes in growth rates in 10 human breast cancer cell lines.	Tetradecanoylphorbol Acetate	112-115	epidermal growth factor receptor	Homo sapiens	223-228
2379149-8	1990	Saturation analysis revealed marked differences between the effects of TPA on EGF binding in ER+ and ER- cell lines.	Tetradecanoylphorbol Acetate	71-74	estrogen receptor 1	Homo sapiens	93-95
2379149-8	1990	Saturation analysis revealed marked differences between the effects of TPA on EGF binding in ER+ and ER- cell lines.	Tetradecanoylphorbol Acetate	71-74	estrogen receptor 1	Homo sapiens	101-103
2379149-9	1990	In ER+ cell lines, 2-h treatment with 10 nM TPA resulted in a marked reduction in the number of high affinity EGF-R sites and a significant decrease in binding affinity.	Tetradecanoylphorbol Acetate	44-47	estrogen receptor 1	Homo sapiens	3-5
2379149-9	1990	In ER+ cell lines, 2-h treatment with 10 nM TPA resulted in a marked reduction in the number of high affinity EGF-R sites and a significant decrease in binding affinity.	Tetradecanoylphorbol Acetate	44-47	epidermal growth factor receptor	Homo sapiens	110-115
2379149-10	1990	Among this group of cell lines there was a significant positive correlation between the ability of TPA to decrease cell growth and the TPA-induced decrease in the number of EGF-R sites/cell (r = 0.82, P less than 0.03).	Tetradecanoylphorbol Acetate	99-102	epidermal growth factor receptor	Homo sapiens	173-178
2379149-10	1990	Among this group of cell lines there was a significant positive correlation between the ability of TPA to decrease cell growth and the TPA-induced decrease in the number of EGF-R sites/cell (r = 0.82, P less than 0.03).	Tetradecanoylphorbol Acetate	135-138	epidermal growth factor receptor	Homo sapiens	173-178
2379149-12	1990	However, growth inhibition was negatively correlated with TPA-induced changes in apparent affinity of the EGF-R (r = 1.00, P less than 0.003) and in the same rank order as the EGF-R concentration in control cells.	Tetradecanoylphorbol Acetate	58-61	epidermal growth factor receptor	Homo sapiens	106-111
2379149-12	1990	However, growth inhibition was negatively correlated with TPA-induced changes in apparent affinity of the EGF-R (r = 1.00, P less than 0.003) and in the same rank order as the EGF-R concentration in control cells.	Tetradecanoylphorbol Acetate	58-61	epidermal growth factor receptor	Homo sapiens	176-181
2379149-13	1990	These data demonstrate differential relationships between TPA-induced changes in growth and EGF-R binding in ER+ and ER- breast cancer cells, thus supporting the view that growth regulatory pathways are markedly different in these two subtypes of human breast cancer.	Tetradecanoylphorbol Acetate	58-61	epidermal growth factor receptor	Homo sapiens	92-97
2379149-13	1990	These data demonstrate differential relationships between TPA-induced changes in growth and EGF-R binding in ER+ and ER- breast cancer cells, thus supporting the view that growth regulatory pathways are markedly different in these two subtypes of human breast cancer.	Tetradecanoylphorbol Acetate	58-61	estrogen receptor 1	Homo sapiens	109-111
2379149-13	1990	These data demonstrate differential relationships between TPA-induced changes in growth and EGF-R binding in ER+ and ER- breast cancer cells, thus supporting the view that growth regulatory pathways are markedly different in these two subtypes of human breast cancer.	Tetradecanoylphorbol Acetate	58-61	estrogen receptor 1	Homo sapiens	117-119
2388825-0	1990	Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes.	Tetradecanoylphorbol Acetate	79-82	Sp3 transcription factor	Homo sapiens	30-34
2167307-6	1990	A 30-min incubation with phorbol 12-myristate 13-acetate (PMA) caused a dose-related translocation of protein kinase C from the cytosol to the cell membrane; after 4 h, the increases in ACTH release and total ACTH content in response to increasing concentrations of PMA were similar to those caused by AVP.	Tetradecanoylphorbol Acetate	25-56	arginine vasopressin	Homo sapiens	302-305
2167307-6	1990	A 30-min incubation with phorbol 12-myristate 13-acetate (PMA) caused a dose-related translocation of protein kinase C from the cytosol to the cell membrane; after 4 h, the increases in ACTH release and total ACTH content in response to increasing concentrations of PMA were similar to those caused by AVP.	Tetradecanoylphorbol Acetate	58-61	arginine vasopressin	Homo sapiens	302-305
2167321-1	1990	Tissue-type plasminogen activator (t-PA) gene expression is regulated by the tumor-promoting phorbol ester, phorbol-12-myristate 13-acetate (PMA), by cyclic AMP analogues, and the cAMP agonist, forskolin.	Tetradecanoylphorbol Acetate	108-139	plasminogen activator, tissue type	Homo sapiens	0-33
2167321-1	1990	Tissue-type plasminogen activator (t-PA) gene expression is regulated by the tumor-promoting phorbol ester, phorbol-12-myristate 13-acetate (PMA), by cyclic AMP analogues, and the cAMP agonist, forskolin.	Tetradecanoylphorbol Acetate	108-139	plasminogen activator, tissue type	Homo sapiens	35-39
2167321-1	1990	Tissue-type plasminogen activator (t-PA) gene expression is regulated by the tumor-promoting phorbol ester, phorbol-12-myristate 13-acetate (PMA), by cyclic AMP analogues, and the cAMP agonist, forskolin.	Tetradecanoylphorbol Acetate	141-144	plasminogen activator, tissue type	Homo sapiens	0-33
2167321-1	1990	Tissue-type plasminogen activator (t-PA) gene expression is regulated by the tumor-promoting phorbol ester, phorbol-12-myristate 13-acetate (PMA), by cyclic AMP analogues, and the cAMP agonist, forskolin.	Tetradecanoylphorbol Acetate	141-144	plasminogen activator, tissue type	Homo sapiens	35-39
2143761-1	1990	Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells.	Tetradecanoylphorbol Acetate	30-61	interleukin 1 beta	Homo sapiens	99-118
2143761-1	1990	Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells.	Tetradecanoylphorbol Acetate	30-61	interleukin 1 beta	Homo sapiens	174-183
2143761-1	1990	Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells.	Tetradecanoylphorbol Acetate	30-61	interleukin 1 beta	Homo sapiens	114-118
2143761-1	1990	Culture medium conditioned by phorbol 12-myristate 13-acetate-differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin-stimulated IL-2 synthesis by LBRM-33-1A5 T cells.	Tetradecanoylphorbol Acetate	30-61	interleukin 2	Homo sapiens	270-274
2388825-1	1990	We have isolated genomic clones from several members of the UV and TPA inducible human spr2 gene-family in order to analyse the regulation of these genes at a molecular level.	Tetradecanoylphorbol Acetate	67-70	Sp3 transcription factor	Homo sapiens	87-91
2174276-4	1990	The drug enhanced vasoactive intestinal polypeptide (VIP)-stimulated PRL-secretion, while thyroliberin (TRH)- and 12-0-tetradecanoyl phorbol-13-acetate (TPA)-elicited PRL egress were slightly reduced indicating a cAMP-mediated reduction of protein kinase C (PK-C) mediated PRL release.	Tetradecanoylphorbol Acetate	153-156	vasoactive intestinal peptide	Rattus norvegicus	53-56
1696432-7	1990	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA; 1 microM) also enhanced maximal secretion to 450% of basal and decreased the EC50 to 0.18 microM Ca2+.	Tetradecanoylphorbol Acetate	18-54	promotion susceptibility QTL 1	Mus musculus	56-59
2127700-8	1990	In both naive and TPA-desensitized human fibroblasts or WISH cells, prolonged IFN treatment induced a desensitized state that was reversible by cycloheximide.	Tetradecanoylphorbol Acetate	18-21	interferon alpha 1	Homo sapiens	78-81
2378984-3	1990	In this study we demonstrate that a specific cytokine, transforming growth factor beta 1 (TGF beta 1), inhibits the phorbol myristate acetate (PMA)-induced differentiation of the Dami human megakaryocytic cell line.	Tetradecanoylphorbol Acetate	116-141	transforming growth factor beta 1	Homo sapiens	55-86
2378984-3	1990	In this study we demonstrate that a specific cytokine, transforming growth factor beta 1 (TGF beta 1), inhibits the phorbol myristate acetate (PMA)-induced differentiation of the Dami human megakaryocytic cell line.	Tetradecanoylphorbol Acetate	116-141	transforming growth factor beta 1	Homo sapiens	90-100
2378984-3	1990	In this study we demonstrate that a specific cytokine, transforming growth factor beta 1 (TGF beta 1), inhibits the phorbol myristate acetate (PMA)-induced differentiation of the Dami human megakaryocytic cell line.	Tetradecanoylphorbol Acetate	143-146	transforming growth factor beta 1	Homo sapiens	55-86
2378984-3	1990	In this study we demonstrate that a specific cytokine, transforming growth factor beta 1 (TGF beta 1), inhibits the phorbol myristate acetate (PMA)-induced differentiation of the Dami human megakaryocytic cell line.	Tetradecanoylphorbol Acetate	143-146	transforming growth factor beta 1	Homo sapiens	90-100
2378984-4	1990	The addition of purified platelet TGF beta 1 inhibits PMA-induced endomitosis in a dose-dependent manner.	Tetradecanoylphorbol Acetate	54-57	transforming growth factor beta 1	Homo sapiens	34-44
1980602-6	1990	A potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, also induced EGFR mRNA.	Tetradecanoylphorbol Acetate	25-61	epidermal growth factor receptor	Homo sapiens	76-80
2118479-3	1990	Recently, AS101 and the protein kinase C (PKC) inducer, phorbol myristate acetate (PMA), were shown to synergize in the secretion of interleukin-2 (IL-2) and colony-stimulating factor (CSF) in vitro, by human and mouse lymphoid cells.	Tetradecanoylphorbol Acetate	83-86	interleukin 2	Homo sapiens	148-152
1695585-5	1990	In fact, treatment with TPA, a powerful inhibitor of differentiation, efficiently prevents myoblasts from producing Apo A-I mRNA, as well as muscle actin mRNA, and causes myotubes to quickly cease Apo A-I mRNA synthesis.	Tetradecanoylphorbol Acetate	24-27	apolipoprotein AI	Gallus gallus	116-123
1695585-5	1990	In fact, treatment with TPA, a powerful inhibitor of differentiation, efficiently prevents myoblasts from producing Apo A-I mRNA, as well as muscle actin mRNA, and causes myotubes to quickly cease Apo A-I mRNA synthesis.	Tetradecanoylphorbol Acetate	24-27	apolipoprotein AI	Gallus gallus	197-204
2118479-3	1990	Recently, AS101 and the protein kinase C (PKC) inducer, phorbol myristate acetate (PMA), were shown to synergize in the secretion of interleukin-2 (IL-2) and colony-stimulating factor (CSF) in vitro, by human and mouse lymphoid cells.	Tetradecanoylphorbol Acetate	56-81	interleukin 2	Homo sapiens	133-146
2118479-3	1990	Recently, AS101 and the protein kinase C (PKC) inducer, phorbol myristate acetate (PMA), were shown to synergize in the secretion of interleukin-2 (IL-2) and colony-stimulating factor (CSF) in vitro, by human and mouse lymphoid cells.	Tetradecanoylphorbol Acetate	56-81	interleukin 2	Homo sapiens	148-152
2118479-3	1990	Recently, AS101 and the protein kinase C (PKC) inducer, phorbol myristate acetate (PMA), were shown to synergize in the secretion of interleukin-2 (IL-2) and colony-stimulating factor (CSF) in vitro, by human and mouse lymphoid cells.	Tetradecanoylphorbol Acetate	83-86	interleukin 2	Homo sapiens	133-146
2145219-9	1990	Addition of PMA induces both p70/75 and p50/55 IL2 receptor upregulation, as well as IL2-dependent proliferation.	Tetradecanoylphorbol Acetate	12-15	interleukin 2	Homo sapiens	47-50
2145219-9	1990	Addition of PMA induces both p70/75 and p50/55 IL2 receptor upregulation, as well as IL2-dependent proliferation.	Tetradecanoylphorbol Acetate	12-15	interleukin 2	Homo sapiens	85-88
2166508-7	1990	Incubation of nerve slices with phorbol 12 myristate-13-acetate caused a marked increase in the phosphorylation of CNP.	Tetradecanoylphorbol Acetate	32-63	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	115-118
2165096-9	1990	When added to PMA-stimulated SKW6.4 cells, IL-6 stimulated additional IgM production.	Tetradecanoylphorbol Acetate	14-17	interleukin 6	Homo sapiens	43-47
19215372-16	1990	Intracellular accumulation of Ca(2+) by the ionophore A23187 and protein kinase C stimulation by the phorbol ester 12-O- tetradecanoyl phorbol acetate (TPA), strongly stimulated GH and prolactin release.	Tetradecanoylphorbol Acetate	115-150	growth hormone 1	Homo sapiens	178-180
19215372-16	1990	Intracellular accumulation of Ca(2+) by the ionophore A23187 and protein kinase C stimulation by the phorbol ester 12-O- tetradecanoyl phorbol acetate (TPA), strongly stimulated GH and prolactin release.	Tetradecanoylphorbol Acetate	115-150	prolactin	Homo sapiens	185-194
19215372-16	1990	Intracellular accumulation of Ca(2+) by the ionophore A23187 and protein kinase C stimulation by the phorbol ester 12-O- tetradecanoyl phorbol acetate (TPA), strongly stimulated GH and prolactin release.	Tetradecanoylphorbol Acetate	152-155	growth hormone 1	Homo sapiens	178-180
19215372-16	1990	Intracellular accumulation of Ca(2+) by the ionophore A23187 and protein kinase C stimulation by the phorbol ester 12-O- tetradecanoyl phorbol acetate (TPA), strongly stimulated GH and prolactin release.	Tetradecanoylphorbol Acetate	152-155	prolactin	Homo sapiens	185-194
2197329-2	1990	We showed previously that GM-CSF production by lectin or phorbol ester (12-O-tetradecanoyl-phorbol-13-acetate (TPA]-treated T cells was unaffected by cyclosporin A whereas IL-2 and IL-3 expression were.	Tetradecanoylphorbol Acetate	72-109	promotion susceptibility QTL 1	Mus musculus	111-114
2386487-3	1990	Previous studies indicated that prior activation of PKC with phorbol myristate acetate (PMA) desensitizes platelets to thrombin stimulation, as indicated by a decreased production of inositol phosphates and decreased Ca2+ mobilization.	Tetradecanoylphorbol Acetate	61-86	coagulation factor II, thrombin	Homo sapiens	119-127
2233705-10	1990	One hour treatment with the phorbol ester tumor promoter, 12-0-tetradecanoyl phorbol-13-acetate (TPA), stimulated a nine-fold increase in release of preexisting, dimeric cell-surface FN (125I-labeled).	Tetradecanoylphorbol Acetate	97-100	fibronectin 1	Homo sapiens	183-185
2233705-11	1990	The major effect of longer term TPA treatment up to nine hours was continued depletion of dimeric cell-surface FN.	Tetradecanoylphorbol Acetate	32-35	fibronectin 1	Homo sapiens	111-113
2386487-3	1990	Previous studies indicated that prior activation of PKC with phorbol myristate acetate (PMA) desensitizes platelets to thrombin stimulation, as indicated by a decreased production of inositol phosphates and decreased Ca2+ mobilization.	Tetradecanoylphorbol Acetate	88-91	coagulation factor II, thrombin	Homo sapiens	119-127
2233705-12	1990	Increased release of cell-surface multimeric FN was also stimulated by TPA, but to a much lesser extent.	Tetradecanoylphorbol Acetate	71-74	fibronectin 1	Homo sapiens	45-47
2233705-13	1990	Release of newly synthesized (pulse-labeled) dimeric FN was also stimulated by TPA though much less than pre-existing FN, and TPA treatment produced a small decrease in the steady-state level of multimeric FN.	Tetradecanoylphorbol Acetate	79-82	fibronectin 1	Homo sapiens	53-55
2386487-6	1990	Pretreatment with PMA abolishes thrombin-stimulated DAG formation (50% inhibition at 60 nM).	Tetradecanoylphorbol Acetate	18-21	coagulation factor II, thrombin	Homo sapiens	32-40
2233705-14	1990	Thus, preexisting cell-surface FN and newly synthesized FN differ dramatically in their susceptibility to TPA treatment.	Tetradecanoylphorbol Acetate	106-109	fibronectin 1	Homo sapiens	31-33
2233705-14	1990	Thus, preexisting cell-surface FN and newly synthesized FN differ dramatically in their susceptibility to TPA treatment.	Tetradecanoylphorbol Acetate	106-109	fibronectin 1	Homo sapiens	56-58
2278884-4	1990	Both p120 mRNA and c-myc mRNA levels were significantly decreased in 12-O-tetradecanoyl-phorbol-13-acetate-differentiated HL-60 leukemic cells and in confluent normal immortalized human fibroblasts (WSI).	Tetradecanoylphorbol Acetate	69-106	NOP2 nucleolar protein	Homo sapiens	5-9
1694174-4	1990	The PKC activators, 12-O-tetradecanoylphorbol-13-acetate and bryostatin-1, induced rapid, stoichiometric hyperphosphorylation of CD34 protein in cells, resulting in a 5-fold increase in CD34 phosphorylation.	Tetradecanoylphorbol Acetate	20-56	proline rich transmembrane protein 2	Homo sapiens	4-7
1694174-4	1990	The PKC activators, 12-O-tetradecanoylphorbol-13-acetate and bryostatin-1, induced rapid, stoichiometric hyperphosphorylation of CD34 protein in cells, resulting in a 5-fold increase in CD34 phosphorylation.	Tetradecanoylphorbol Acetate	20-56	CD34 molecule	Homo sapiens	129-133
1694174-4	1990	The PKC activators, 12-O-tetradecanoylphorbol-13-acetate and bryostatin-1, induced rapid, stoichiometric hyperphosphorylation of CD34 protein in cells, resulting in a 5-fold increase in CD34 phosphorylation.	Tetradecanoylphorbol Acetate	20-56	CD34 molecule	Homo sapiens	186-190
1695733-6	1990	These results suggest that CpG methylation inhibits proenkephalin gene expression by directly interfering with the binding of a positively acting transcription factor previously shown to be essential for maximal basal, cAMP, and TPA inducible transcription.	Tetradecanoylphorbol Acetate	229-232	proenkephalin	Homo sapiens	52-65
2194392-7	1990	When stimulated in vitro by anti-mu and TPA, (phorbol ester) tumor cells showed a decrease in CD21 and Slg and a stronger expression of CD25, T9, T10, and PCA1, with evidence of Ig secretion in four out of the seven cases studied.	Tetradecanoylphorbol Acetate	40-43	complement C3d receptor 2	Homo sapiens	94-98
2353819-8	1990	Translocation of the enzyme was also found after treatment of platelets with thrombin, although the response was of lower magnitude than that induced by TPA.	Tetradecanoylphorbol Acetate	153-156	coagulation factor II, thrombin	Homo sapiens	77-85
2104228-2	1990	Purified rabbit peripheral blood B cells, when stimulated with a combination of ionomycin (0.5 microgram/mL) and phorbol myristate acetate (PMA) (1 ng/mL), secreted a soluble factor in the culture medium that supported the IL 2-dependent cell line CTLL-2.	Tetradecanoylphorbol Acetate	113-138	interleukin-2	Oryctolagus cuniculus	223-227
2104228-2	1990	Purified rabbit peripheral blood B cells, when stimulated with a combination of ionomycin (0.5 microgram/mL) and phorbol myristate acetate (PMA) (1 ng/mL), secreted a soluble factor in the culture medium that supported the IL 2-dependent cell line CTLL-2.	Tetradecanoylphorbol Acetate	140-143	interleukin-2	Oryctolagus cuniculus	223-227
2164068-9	1990	Exposure of [3H]choline-labeled macrophages to IFN-gamma resulted in an increase in the basal level of aqueous [3H]choline metabolites as well as potentiating the production of [3H]choline in response to PAF, PMA, and ionomycin.	Tetradecanoylphorbol Acetate	209-212	interferon gamma	Mus musculus	47-56
2165399-3	1990	In contrast, protein kinase C (PK-C)-mediated desensitization by incubation with phorbol esters [PMA (phorbol 12-myristate 13-acetate)], leading to a time- and dose-dependent inhibition of cholinergically stimulated InsP release (95% inhibition after 4 h with 0.1 microM-PMA), is accompanied by only a 40% decrease in muscarinic receptor binding, which suggests an additional mechanism of negative-feedback control.	Tetradecanoylphorbol Acetate	97-100	proline rich transmembrane protein 2	Homo sapiens	13-29
2165399-3	1990	In contrast, protein kinase C (PK-C)-mediated desensitization by incubation with phorbol esters [PMA (phorbol 12-myristate 13-acetate)], leading to a time- and dose-dependent inhibition of cholinergically stimulated InsP release (95% inhibition after 4 h with 0.1 microM-PMA), is accompanied by only a 40% decrease in muscarinic receptor binding, which suggests an additional mechanism of negative-feedback control.	Tetradecanoylphorbol Acetate	97-100	proline rich transmembrane protein 2	Homo sapiens	31-35
2165399-3	1990	In contrast, protein kinase C (PK-C)-mediated desensitization by incubation with phorbol esters [PMA (phorbol 12-myristate 13-acetate)], leading to a time- and dose-dependent inhibition of cholinergically stimulated InsP release (95% inhibition after 4 h with 0.1 microM-PMA), is accompanied by only a 40% decrease in muscarinic receptor binding, which suggests an additional mechanism of negative-feedback control.	Tetradecanoylphorbol Acetate	102-133	proline rich transmembrane protein 2	Homo sapiens	13-29
2165399-3	1990	In contrast, protein kinase C (PK-C)-mediated desensitization by incubation with phorbol esters [PMA (phorbol 12-myristate 13-acetate)], leading to a time- and dose-dependent inhibition of cholinergically stimulated InsP release (95% inhibition after 4 h with 0.1 microM-PMA), is accompanied by only a 40% decrease in muscarinic receptor binding, which suggests an additional mechanism of negative-feedback control.	Tetradecanoylphorbol Acetate	102-133	proline rich transmembrane protein 2	Homo sapiens	31-35
2165399-3	1990	In contrast, protein kinase C (PK-C)-mediated desensitization by incubation with phorbol esters [PMA (phorbol 12-myristate 13-acetate)], leading to a time- and dose-dependent inhibition of cholinergically stimulated InsP release (95% inhibition after 4 h with 0.1 microM-PMA), is accompanied by only a 40% decrease in muscarinic receptor binding, which suggests an additional mechanism of negative-feedback control.	Tetradecanoylphorbol Acetate	271-274	proline rich transmembrane protein 2	Homo sapiens	13-29
2165399-3	1990	In contrast, protein kinase C (PK-C)-mediated desensitization by incubation with phorbol esters [PMA (phorbol 12-myristate 13-acetate)], leading to a time- and dose-dependent inhibition of cholinergically stimulated InsP release (95% inhibition after 4 h with 0.1 microM-PMA), is accompanied by only a 40% decrease in muscarinic receptor binding, which suggests an additional mechanism of negative-feedback control.	Tetradecanoylphorbol Acetate	271-274	proline rich transmembrane protein 2	Homo sapiens	31-35
2165399-6	1990	Long-term incubation (4-24 h) with PMA resulted in a complete down-regulation of cytosolic and particulate PK-C activity.	Tetradecanoylphorbol Acetate	35-38	proline rich transmembrane protein 2	Homo sapiens	107-111
1694858-14	1990	Contrastingly, human umbilical vein endothelial cells (HUVE cells), which expressed no bFGF and aFGF mRNA at a basal level, were induced to express bFGF but not aFGF mRNA when stimulated by TPA.	Tetradecanoylphorbol Acetate	190-193	fibroblast growth factor 2	Homo sapiens	148-152
2135379-4	1990	In monocyte-derived macrophages, both IFN-alpha and IFN-beta stimulated the phorbol myristate acetate (PMA) induced OB response in the patient group as well as in the blood donor control group.	Tetradecanoylphorbol Acetate	76-101	interferon alpha 1	Homo sapiens	38-47
2135379-4	1990	In monocyte-derived macrophages, both IFN-alpha and IFN-beta stimulated the phorbol myristate acetate (PMA) induced OB response in the patient group as well as in the blood donor control group.	Tetradecanoylphorbol Acetate	103-106	interferon alpha 1	Homo sapiens	38-47
2163316-13	1990	However, pretreatment with PMA completely blocked both phases of the synergistic response to the combination of AVP and CRF.	Tetradecanoylphorbol Acetate	27-30	arginine vasopressin	Rattus norvegicus	112-115
2198321-3	1990	These are brought about by the ability of fibrin (1) to bind thrombin at a noncatalytic site, thus limiting its diffusability but at the same time preserving its catalytic potential; (2) to bind fXIII, regulate its activation to fXIIIa, and limit further activation of fXIII once fibrin cross-linking has occurred; and (3) to bind alpha 2-PI, tPA, and plasminogen and regulate the initiation and propagation of fibrinolysis.	Tetradecanoylphorbol Acetate	343-346	coagulation factor II, thrombin	Homo sapiens	61-69
2365815-1	1990	The phorbol myristate acetate (PMA)-differentiated myelomonocytic cell line, THP-1, and human alveolar macrophages contain the cysteine proteinase cathepsin L.	Tetradecanoylphorbol Acetate	4-29	GLI family zinc finger 2	Homo sapiens	77-82
2365815-1	1990	The phorbol myristate acetate (PMA)-differentiated myelomonocytic cell line, THP-1, and human alveolar macrophages contain the cysteine proteinase cathepsin L.	Tetradecanoylphorbol Acetate	4-29	cathepsin L	Homo sapiens	147-158
2365815-1	1990	The phorbol myristate acetate (PMA)-differentiated myelomonocytic cell line, THP-1, and human alveolar macrophages contain the cysteine proteinase cathepsin L.	Tetradecanoylphorbol Acetate	31-34	GLI family zinc finger 2	Homo sapiens	77-82
2365815-1	1990	The phorbol myristate acetate (PMA)-differentiated myelomonocytic cell line, THP-1, and human alveolar macrophages contain the cysteine proteinase cathepsin L.	Tetradecanoylphorbol Acetate	31-34	cathepsin L	Homo sapiens	147-158
1973074-8	1990	EGF and TPA had differential effects on down-modulation of the EGFR in cells that express either one or both species of receptor proteins.	Tetradecanoylphorbol Acetate	8-11	epidermal growth factor receptor	Homo sapiens	63-67
2165203-1	1990	Northern blot analysis of RNA isolated from HL-60 cells before and after differentiation induction by TPA and DMSO showed that four MPO mRNA species (3.3, 3.1, 2.7, and 2.5 kb, respectively designated alpha 1, beta 1, alpha 2, and beta 2) are expressed in HL-60 cells.	Tetradecanoylphorbol Acetate	102-105	myeloperoxidase	Homo sapiens	132-135
2151306-6	1990	It has been reported that the epidermal beta-adrenergic adenylate cyclase response is decreased following the TPA- (and OAG-) induced activation of protein kinase C. Human recombinant IFN-gamma, however, had no effect on the beta-adrenergic response of the human epidermis.	Tetradecanoylphorbol Acetate	110-113	interferon gamma	Homo sapiens	184-193
2164042-5	1990	However, preincubation of PMN with TNF in suspension led to a decrease in cellular adhesiveness, degranulation, and burst activity in response to a secondary stimulus of TNF under adherent conditions, although cells remained fully responsive toward phorbol myristate acetate.	Tetradecanoylphorbol Acetate	249-274	tumor necrosis factor	Homo sapiens	35-38
2113051-4	1990	Inhibition of protein kinase C by staurosporine or chronic treatment of the cells with phorbol 12-myristate 13-acetate prevented the inhibitory effect of PDGF on the [Ca2+]i response to vasopressin but not bradykinin.	Tetradecanoylphorbol Acetate	87-118	arginine vasopressin	Homo sapiens	186-197
2207658-2	1990	12-O-Tetradecanoyl-phorbol-13-acetate (TPA), a potent activator of protein kinase C (PKC), increased [125I]insulin binding in a time- and concentration-dependent manner with a maximally effective dose of 50 nM TPA for 2 h in glial cells.	Tetradecanoylphorbol Acetate	0-37	insulin	Homo sapiens	107-114
2207658-2	1990	12-O-Tetradecanoyl-phorbol-13-acetate (TPA), a potent activator of protein kinase C (PKC), increased [125I]insulin binding in a time- and concentration-dependent manner with a maximally effective dose of 50 nM TPA for 2 h in glial cells.	Tetradecanoylphorbol Acetate	39-42	insulin	Homo sapiens	107-114
2207658-2	1990	12-O-Tetradecanoyl-phorbol-13-acetate (TPA), a potent activator of protein kinase C (PKC), increased [125I]insulin binding in a time- and concentration-dependent manner with a maximally effective dose of 50 nM TPA for 2 h in glial cells.	Tetradecanoylphorbol Acetate	210-213	insulin	Homo sapiens	107-114
2207658-4	1990	The TPA effect on glial [125I]insulin binding was specific as evidenced by the observation that potencies of phorbol ester analogs to increase [125I]insulin binding were similar to their abilities to stimulate PKC.	Tetradecanoylphorbol Acetate	4-7	insulin	Homo sapiens	30-37
2207658-6	1990	Removal of the TPA after pretreatment resulted in a recovery from its effects within 6 h. The increase in glial insulin binding was not accompanied by an increase in insulin-sensitive glucose uptake, suggesting that TPA inactivates the glial cell receptors as it increases their numbers.	Tetradecanoylphorbol Acetate	216-219	insulin	Homo sapiens	112-119
2207658-4	1990	The TPA effect on glial [125I]insulin binding was specific as evidenced by the observation that potencies of phorbol ester analogs to increase [125I]insulin binding were similar to their abilities to stimulate PKC.	Tetradecanoylphorbol Acetate	4-7	insulin	Homo sapiens	149-156
1693527-6	1990	Upon induction of the cells towards macrophages with tetradecanoylphorbol-13-acetate (TPA) and ionomycin, steady state levels of CD34 mRNA decreased rapidly.	Tetradecanoylphorbol Acetate	86-89	CD34 molecule	Homo sapiens	129-133
2207658-5	1990	Competitive-inhibition experiments indicated that this effect of TPA was due primarily to an increase in the number of high affinity insulin binding sites on glial cells.	Tetradecanoylphorbol Acetate	65-68	insulin	Homo sapiens	133-140
2207658-6	1990	Removal of the TPA after pretreatment resulted in a recovery from its effects within 6 h. The increase in glial insulin binding was not accompanied by an increase in insulin-sensitive glucose uptake, suggesting that TPA inactivates the glial cell receptors as it increases their numbers.	Tetradecanoylphorbol Acetate	15-18	insulin	Homo sapiens	112-119
2112411-6	1990	Furthermore, GP IIIa phosphorylation increased four-fold in platelets activated with thrombin or phorbol 12-myristate 13-acetate, but not at all in platelets treated with prostacyclin, an inhibitor of platelet activation.	Tetradecanoylphorbol Acetate	97-128	integrin subunit beta 3	Homo sapiens	13-20
1693534-3	1990	Using a monoclonal antibody specific for phosphotyrosine, the present study shows that the chemotactic peptides FMLP and leukotriene B4, the phorbol ester phorbol myristate acetate (PMA), and the calcium ionophore A23187 induce an increase in tyrosine phosphorylation of a number of neutrophil proteins.	Tetradecanoylphorbol Acetate	155-180	formyl peptide receptor 1	Homo sapiens	112-116
1693534-3	1990	Using a monoclonal antibody specific for phosphotyrosine, the present study shows that the chemotactic peptides FMLP and leukotriene B4, the phorbol ester phorbol myristate acetate (PMA), and the calcium ionophore A23187 induce an increase in tyrosine phosphorylation of a number of neutrophil proteins.	Tetradecanoylphorbol Acetate	182-185	formyl peptide receptor 1	Homo sapiens	112-116
2161879-7	1990	Moreover, local anesthetics rapidly inhibited aggregation, O2- generation, and degranulation elicited by PMA (1 microgram/ml) or the Ca ionophore A23187 (10 microM): the effects of cocaine could therefore not be attributed to unique actions at the FMLP receptor.	Tetradecanoylphorbol Acetate	105-108	formyl peptide receptor 1	Homo sapiens	248-261
2347071-0	1990	Modulation of catalase activities in murine epidermal cells as a function of differentiation and exposure to 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	109-145	catalase	Mus musculus	14-22
2141042-0	1990	Differential regulation of the human IFN-gamma receptor expression in Raji and IM9 lymphoblastoid cells versus THP-1 monocytic cells by IFN-gamma and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	150-175	interferon gamma	Homo sapiens	37-46
2161846-5	1990	Stimulation of U937 cells with phorbol 12-myristate 13-acetate was accompanied by a further reduction in receptor-bound uPA inhibition by PAI-1 and PAI-2 to 1.7 x 10(6) and 1.1 x 10(5) M-1 s-1, respectively.	Tetradecanoylphorbol Acetate	31-62	plasminogen activator, urokinase	Homo sapiens	120-123
2193536-7	1990	PTH also augmented phorbol ester (TPA)-induced insulin release, stimulated adenosine 3",5"-cyclic monophosphate (cAMP) generation by pancreatic islets, and significantly increased (+50 +/- 2.7%, P less than 0.01) their cytosolic calcium.	Tetradecanoylphorbol Acetate	34-37	parathyroid hormone	Rattus norvegicus	0-3
2347071-3	1990	12-O-Tetradecanoylphorbol-13-acetate (TPA) treatment of proliferating MEKs cultured in low Ca2+ medium resulted in (i) an initial suppression of proliferation, (ii) the accelerated detachment and differentiation of detached MEKs and (iii) a suppression of catalase induction in the detached population.	Tetradecanoylphorbol Acetate	0-36	catalase	Mus musculus	256-264
2347071-3	1990	12-O-Tetradecanoylphorbol-13-acetate (TPA) treatment of proliferating MEKs cultured in low Ca2+ medium resulted in (i) an initial suppression of proliferation, (ii) the accelerated detachment and differentiation of detached MEKs and (iii) a suppression of catalase induction in the detached population.	Tetradecanoylphorbol Acetate	38-41	catalase	Mus musculus	256-264
2347071-9	1990	Catalase activity in the more differentiated MEKs was reduced approximately 33% within 24 h of topical treatment of dorsal skin with a promoting dose of TPA.	Tetradecanoylphorbol Acetate	153-156	catalase	Mus musculus	0-8
2347071-11	1990	Collectively, these studies demonstrate that per cell catalase activities increase as MEKs differentiate, and that TPA suppresses the increases in catalase activities that normally occur during differentiation.	Tetradecanoylphorbol Acetate	115-118	catalase	Mus musculus	147-155
2113537-6	1990	Pretreatment with 100 nM PMA for 5 min also caused a 2-fold enhancement of thrombin-stimulated (1 U/ml) PGI2 production in HUVEC.	Tetradecanoylphorbol Acetate	25-28	coagulation factor II, thrombin	Homo sapiens	75-83
2351106-1	1990	Using primary cultures of dispersed rat fetal hypothalami, we studied the effect of forskolin and the phorbol ester 12-o-tetradecanoyl phorbol 13-acetate, activators of protein kinase A and C, respectively, on corticotropin-releasing hormone (CRH) regulation.	Tetradecanoylphorbol Acetate	116-153	corticotropin releasing hormone	Rattus norvegicus	210-241
2113537-12	1990	However, thrombin-stimulated (1 U/ml) PAF production was enhanced 2.6-fold by preincubation with 100 nM PMA.	Tetradecanoylphorbol Acetate	104-107	coagulation factor II, thrombin	Homo sapiens	9-17
2113537-13	1990	The protein kinase C inhibitors H-7 and staurosporine ablated the enhancing effect of PMA on thrombin-stimulated PGI2 and PAF biosynthesis.	Tetradecanoylphorbol Acetate	86-89	coagulation factor II, thrombin	Homo sapiens	93-101
2113601-2	1990	The phorbol ester TPA and the natural compound Bryostatin 1 (Bryo) were used to directly stimulate protein kinase C (PKC) while the calcium ionophone A23187 was employed to increase intracellular Ca2+.	Tetradecanoylphorbol Acetate	18-21	proline rich transmembrane protein 2	Homo sapiens	99-115
1972179-7	1990	HUVEC exposed 18 h to TNF were considerably more susceptible to lysis by PMA-activated EOs and reagent H2O2, demonstrating a direct effect of TNF upon endothelium, perhaps through inhibition of antioxidant defenses.	Tetradecanoylphorbol Acetate	73-76	tumor necrosis factor	Homo sapiens	22-25
1972179-7	1990	HUVEC exposed 18 h to TNF were considerably more susceptible to lysis by PMA-activated EOs and reagent H2O2, demonstrating a direct effect of TNF upon endothelium, perhaps through inhibition of antioxidant defenses.	Tetradecanoylphorbol Acetate	73-76	tumor necrosis factor	Homo sapiens	142-145
1972968-9	1990	TPA augmented PHA-induced T cell proliferation but the addition of PTH to the culture stimulated by PHA and TPA did not augment further the proliferation of T cells.	Tetradecanoylphorbol Acetate	108-111	parathyroid hormone	Homo sapiens	67-70
2113601-2	1990	The phorbol ester TPA and the natural compound Bryostatin 1 (Bryo) were used to directly stimulate protein kinase C (PKC) while the calcium ionophone A23187 was employed to increase intracellular Ca2+.	Tetradecanoylphorbol Acetate	18-21	proline rich transmembrane protein 2	Homo sapiens	117-120
2172792-3	1990	In cultured pituitary cells, TSH beta gene transcription was stimulated by 2 h of 10(-9) M TRH (2- to 4-fold), 100 nM PMA (2- to 6-fold), or 2 microM forskolin (1.5- to 2.5-fold) treatment, with additive interactions among all three effectors.	Tetradecanoylphorbol Acetate	118-121	thyroid stimulating hormone subunit beta	Rattus norvegicus	29-37
2172796-4	1990	Phorbol-myristate acetate was found to activate the human uPA promoter in Sertoli cell cultures from mice of both ages, even though the effect was less evident in cultures of 18-day-old animals.	Tetradecanoylphorbol Acetate	0-25	plasminogen activator, urokinase	Homo sapiens	58-61
2359403-13	1990	The ionophore ionomycin (10 microM) and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) (50 nM) were both able to elicit changes in CaM distribution.	Tetradecanoylphorbol Acetate	96-99	calmodulin 1	Homo sapiens	145-148
2359403-15	1990	TPA elicited a decrease in membrane-associated CaM, with a corresponding increase in CaM in the cytosol.	Tetradecanoylphorbol Acetate	0-3	calmodulin 1	Homo sapiens	47-50
2359403-15	1990	TPA elicited a decrease in membrane-associated CaM, with a corresponding increase in CaM in the cytosol.	Tetradecanoylphorbol Acetate	0-3	calmodulin 1	Homo sapiens	85-88
2159467-3	1990	Dexamethasone treatment of Jurkat T77 cells inhibited the TPA/A23187-dependent activation of the transcription from the transfected pIL2CAT, containing 600 base pairs of the genomic sequences upstream of the coding region of IL2 gene, including the TPA/calcium responsive cis-regulatory elements and promoter sequences, driving the expression of the chloramphenicol acetyltransferase (CAT) gene.	Tetradecanoylphorbol Acetate	58-61	interleukin 2	Homo sapiens	133-136
2110502-2	1990	Incubation of leukemic cells in the presence of the phorbol esters, 12-O-tetradecanoyl-phorbol-13-acetate or phorbol 12,13-dibutyrate, resulted in reduction of ADA and TdT mRNA levels, while PNP mRNA levels increased under the same treatment.	Tetradecanoylphorbol Acetate	68-105	purine nucleoside phosphorylase	Homo sapiens	191-194
1972016-1	1990	Treatment of drug-resistant human KB carcinoma cells (KB-V1) with 0.2 microM phorbol 12-myristate 13-acetate (PMA) resulted in increases of 4-fold in both membrane-associated protein kinase C activity and phosphorylation of P-glycoprotein.	Tetradecanoylphorbol Acetate	77-108	ATP binding cassette subfamily B member 1	Homo sapiens	224-238
1972016-1	1990	Treatment of drug-resistant human KB carcinoma cells (KB-V1) with 0.2 microM phorbol 12-myristate 13-acetate (PMA) resulted in increases of 4-fold in both membrane-associated protein kinase C activity and phosphorylation of P-glycoprotein.	Tetradecanoylphorbol Acetate	110-113	ATP binding cassette subfamily B member 1	Homo sapiens	224-238
2159467-2	1990	Dexamethasone treatment of the Jurkat T77 cell clone inhibited the enhancing effect of 12-O-tetradecanoylporbol-13-acetate (TPA) and the calcium ionophore A23187 on the interleukin 2 (IL2) mRNA levels and gene transcription from intact nuclei.	Tetradecanoylphorbol Acetate	124-127	interleukin 2	Homo sapiens	184-187
2159816-2	1990	We have studied the expression of the EPA/TIMP gene at the mRNA and protein levels during 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced megakaryoblastic differentiation of K562 human chronic myeloid leukemia cells.	Tetradecanoylphorbol Acetate	90-127	TIMP metallopeptidase inhibitor 1	Homo sapiens	42-46
2186042-5	1990	Preincubation of Jurkat cells with protein kinase inhibitor H7 or staurosporine blocked PK-C activation by either TNF or phorbol 12-myristate 12-acetate (PMA).	Tetradecanoylphorbol Acetate	154-157	proline rich transmembrane protein 2	Homo sapiens	88-92
2159816-2	1990	We have studied the expression of the EPA/TIMP gene at the mRNA and protein levels during 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced megakaryoblastic differentiation of K562 human chronic myeloid leukemia cells.	Tetradecanoylphorbol Acetate	129-132	TIMP metallopeptidase inhibitor 1	Homo sapiens	42-46
2159816-3	1990	Northern hybridization analysis showed that the EPA/TIMP mRNA was increased within 3 hours of TPA-induction and reached maximal levels (about 50-fold induction) during the first day of treatment.	Tetradecanoylphorbol Acetate	94-97	TIMP metallopeptidase inhibitor 1	Homo sapiens	52-56
2159816-5	1990	The increase of EPA/TIMP mRNA correlated with increased EPA/TIMP protein biosynthesis and secretion: the TPA-induced cells secreted substantially enhanced amounts of metabolically labeled proteins, of which EPA/TIMP represented up to 50% after the first day of treatment (over 100-fold induction).	Tetradecanoylphorbol Acetate	105-108	TIMP metallopeptidase inhibitor 1	Homo sapiens	20-24
2159816-5	1990	The increase of EPA/TIMP mRNA correlated with increased EPA/TIMP protein biosynthesis and secretion: the TPA-induced cells secreted substantially enhanced amounts of metabolically labeled proteins, of which EPA/TIMP represented up to 50% after the first day of treatment (over 100-fold induction).	Tetradecanoylphorbol Acetate	105-108	TIMP metallopeptidase inhibitor 1	Homo sapiens	60-64
2159816-5	1990	The increase of EPA/TIMP mRNA correlated with increased EPA/TIMP protein biosynthesis and secretion: the TPA-induced cells secreted substantially enhanced amounts of metabolically labeled proteins, of which EPA/TIMP represented up to 50% after the first day of treatment (over 100-fold induction).	Tetradecanoylphorbol Acetate	105-108	TIMP metallopeptidase inhibitor 1	Homo sapiens	60-64
2344355-5	1990	The tumour promoters phorbol 12-myristate 13-acetate (PMA) and teleocidin, at low concentrations, enhanced PLA2 activity at temperatures below the phase-transition temperature of the membrane, but, in contrast, high concentrations of the tumour promoters suppressed PLA2 activity.	Tetradecanoylphorbol Acetate	21-52	phospholipase A2 group IB	Homo sapiens	107-111
2159816-7	1990	EPA/TIMP induction required continuous protein synthesis, being completely inhibited by addition of the protein synthesis inhibitor cycloheximide simultaneously with TPA, but only partially inhibited in a time-dependent manner if cycloheximide was added after TPA.	Tetradecanoylphorbol Acetate	166-169	TIMP metallopeptidase inhibitor 1	Homo sapiens	4-8
2344355-5	1990	The tumour promoters phorbol 12-myristate 13-acetate (PMA) and teleocidin, at low concentrations, enhanced PLA2 activity at temperatures below the phase-transition temperature of the membrane, but, in contrast, high concentrations of the tumour promoters suppressed PLA2 activity.	Tetradecanoylphorbol Acetate	21-52	phospholipase A2 group IB	Homo sapiens	266-270
2344355-5	1990	The tumour promoters phorbol 12-myristate 13-acetate (PMA) and teleocidin, at low concentrations, enhanced PLA2 activity at temperatures below the phase-transition temperature of the membrane, but, in contrast, high concentrations of the tumour promoters suppressed PLA2 activity.	Tetradecanoylphorbol Acetate	54-57	phospholipase A2 group IB	Homo sapiens	107-111
2159816-7	1990	EPA/TIMP induction required continuous protein synthesis, being completely inhibited by addition of the protein synthesis inhibitor cycloheximide simultaneously with TPA, but only partially inhibited in a time-dependent manner if cycloheximide was added after TPA.	Tetradecanoylphorbol Acetate	260-263	TIMP metallopeptidase inhibitor 1	Homo sapiens	4-8
2344355-5	1990	The tumour promoters phorbol 12-myristate 13-acetate (PMA) and teleocidin, at low concentrations, enhanced PLA2 activity at temperatures below the phase-transition temperature of the membrane, but, in contrast, high concentrations of the tumour promoters suppressed PLA2 activity.	Tetradecanoylphorbol Acetate	54-57	phospholipase A2 group IB	Homo sapiens	266-270
2159816-9	1990	This response was associated with enhanced activity of a transfected recombinant reporter plasmid containing binding sites for the jun/fos transcription factor complex (AP-1) similar to the TPA-responsive element (TRE) sequence we found in the EPA/TIMP gene promoter.	Tetradecanoylphorbol Acetate	190-193	TIMP metallopeptidase inhibitor 1	Homo sapiens	248-252
2328536-2	1990	IL-2-mediated signals are required in late G1 for transition to S phase after ionomycin and PMA treatment.	Tetradecanoylphorbol Acetate	92-95	interleukin-2	Oryctolagus cuniculus	0-4
2139363-7	1990	Furthermore, when anti-CD3 and phorbol myristate acetate (PMA) were added together, they exerted a very marked synergistic effect on both the proliferation of, and IL 2 production by, cord PBMC.	Tetradecanoylphorbol Acetate	31-56	interleukin 2	Homo sapiens	164-168
2139363-7	1990	Furthermore, when anti-CD3 and phorbol myristate acetate (PMA) were added together, they exerted a very marked synergistic effect on both the proliferation of, and IL 2 production by, cord PBMC.	Tetradecanoylphorbol Acetate	58-61	interleukin 2	Homo sapiens	164-168
2328536-4	1990	We have shown earlier that rabbit B cells can be activated to produce IL-2 and express functional IL-2 receptors after treatment with ionomycin and PMA.	Tetradecanoylphorbol Acetate	148-151	interleukin-2	Oryctolagus cuniculus	70-74
2328536-4	1990	We have shown earlier that rabbit B cells can be activated to produce IL-2 and express functional IL-2 receptors after treatment with ionomycin and PMA.	Tetradecanoylphorbol Acetate	148-151	interleukin-2	Oryctolagus cuniculus	98-102
2328536-9	1990	(ii) B cell blasts in G1 (produced by treatment of resting B cells with ionomycin and PMA) showed DNA synthesis in response to IL-2, but showed very little DNA synthesis in response to restimulation with ionomycin and PMA.	Tetradecanoylphorbol Acetate	86-89	interleukin-2	Oryctolagus cuniculus	127-131
2162322-5	1990	The IL-6 activity in culture supernatants of EBV-transformed B cells, though much less than that of lipopolysaccharide (LPS)-stimulated monocytes, was increased by the addition of phorbol myristate acetate.	Tetradecanoylphorbol Acetate	180-205	interleukin 6	Homo sapiens	4-8
2113479-4	1990	Constitutive production of IL 6 in early passage lines could be enhanced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and recombinant (r)IL 4 but not by rIL 1 alpha or rIL 1 beta.	Tetradecanoylphorbol Acetate	94-125	interleukin 6	Homo sapiens	27-31
2113479-4	1990	Constitutive production of IL 6 in early passage lines could be enhanced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and recombinant (r)IL 4 but not by rIL 1 alpha or rIL 1 beta.	Tetradecanoylphorbol Acetate	127-130	interleukin 6	Homo sapiens	27-31
1970444-6	1990	These data suggest that (1) TPA inhibits HIV-induced syncytia formation through down-modulation of CD4 molecules on the surface of MOLT-4 cells and (2) PKC may play an important role in cell to cell as well as in cell-free infection of HIV.	Tetradecanoylphorbol Acetate	28-31	CD4 molecule	Homo sapiens	99-102
1692028-5	1990	Upon exposure to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), the amount of both vimentin and cytokeratin appeared to be greatly increased within 3 days and was found both in dispersed cytoplasmic fibrils, in large spherical, eccentric aggregates, as well as in cytoplasmic fibrils in cells spreading on fibronectin.	Tetradecanoylphorbol Acetate	35-71	fibronectin 1	Homo sapiens	321-332
1692028-5	1990	Upon exposure to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), the amount of both vimentin and cytokeratin appeared to be greatly increased within 3 days and was found both in dispersed cytoplasmic fibrils, in large spherical, eccentric aggregates, as well as in cytoplasmic fibrils in cells spreading on fibronectin.	Tetradecanoylphorbol Acetate	73-76	fibronectin 1	Homo sapiens	321-332
2325648-9	1990	We compared the 80-kilodalton (kDa) PKC substrate phosphorylation in 3T3 and TNR9 cells by using two-dimensional gels and found that TNR9 cells treated with TPA for 30 min contained only 10 to 15% as much 32Pi associated with the 80-kDa as did parental cells.	Tetradecanoylphorbol Acetate	157-160	tenascin R	Mus musculus	77-80
1970444-0	1990	The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway.	Tetradecanoylphorbol Acetate	18-21	proline rich transmembrane protein 2	Homo sapiens	128-144
1970444-2	1990	Interestingly, the production of HIV-specific p24 antigen in the culture fluid was significantly enhanced by TPA.	Tetradecanoylphorbol Acetate	109-112	transmembrane p24 trafficking protein 2	Homo sapiens	46-49
2158514-4	1990	In 8 of 10 patients studied, PMN capacity to oxidize intracellular dichlorofluorescein dye, an indirect measurement of O2- production in response to PMA stimulation, decreased after IL-2 administration (pre-IL-2 mean dichlorofluorescein oxidation (by channel number) 243 +/- 128 vs 3-day post-IL-2 87 +/- 86, p2 less than 0.02).	Tetradecanoylphorbol Acetate	149-152	interleukin 2	Homo sapiens	182-186
2183031-6	1990	Mutations in the NF-kappa B-binding site abolished inducibility of IL-6 promoter-cat constructs in U-937 cells by lipopolysaccharide, tumor necrosis factor alpha, the double-stranded RNA poly(IC), or phytohemagglutinin and in HeLa cells by tumor necrosis factor alpha and drastically reduced but did not completely eliminate inducibility in HeLa cells stimulated by double-stranded RNA poly(IC) or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	398-429	nuclear factor kappa B subunit 1	Homo sapiens	17-27
2183031-6	1990	Mutations in the NF-kappa B-binding site abolished inducibility of IL-6 promoter-cat constructs in U-937 cells by lipopolysaccharide, tumor necrosis factor alpha, the double-stranded RNA poly(IC), or phytohemagglutinin and in HeLa cells by tumor necrosis factor alpha and drastically reduced but did not completely eliminate inducibility in HeLa cells stimulated by double-stranded RNA poly(IC) or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	398-429	interleukin 6	Homo sapiens	67-71
1970444-3	1990	TPA down-modulated the expression of CD4.	Tetradecanoylphorbol Acetate	0-3	CD4 molecule	Homo sapiens	37-40
1970444-6	1990	These data suggest that (1) TPA inhibits HIV-induced syncytia formation through down-modulation of CD4 molecules on the surface of MOLT-4 cells and (2) PKC may play an important role in cell to cell as well as in cell-free infection of HIV.	Tetradecanoylphorbol Acetate	28-31	proline rich transmembrane protein 2	Homo sapiens	152-155
1970444-5	1990	The effects of TPA on syncytia formation and on CD4 expression were specifically interfered with by nontoxic doses of blockers of protein kinase C (PKC) such as staurosporine and H7.	Tetradecanoylphorbol Acetate	15-18	CD4 molecule	Homo sapiens	48-51
1970444-5	1990	The effects of TPA on syncytia formation and on CD4 expression were specifically interfered with by nontoxic doses of blockers of protein kinase C (PKC) such as staurosporine and H7.	Tetradecanoylphorbol Acetate	15-18	proline rich transmembrane protein 2	Homo sapiens	130-146
2321243-0	1990	Differential effects of 12-O-tetradecanoylphorbol 13-acetate on cytochrome P-450-dependent monooxygenase activities in rat hepatoma cells: induction of P-450I and suppression of P-450II.	Tetradecanoylphorbol Acetate	24-60	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	64-80
1970444-5	1990	The effects of TPA on syncytia formation and on CD4 expression were specifically interfered with by nontoxic doses of blockers of protein kinase C (PKC) such as staurosporine and H7.	Tetradecanoylphorbol Acetate	15-18	proline rich transmembrane protein 2	Homo sapiens	148-151
2334431-3	1990	Furthermore, prolonged incubation of WISH cells with 12-O-tetradecanoylphorbol 13 acetate (TPA) diminished the TPA effect on the inhibition of EGF binding to the cells due to the desensitization of protein kinase C; however, TNF still reduced the EGF binding to the cells pretreated with TPA for a long time.	Tetradecanoylphorbol Acetate	53-89	tumor necrosis factor	Homo sapiens	225-228
2334431-3	1990	Furthermore, prolonged incubation of WISH cells with 12-O-tetradecanoylphorbol 13 acetate (TPA) diminished the TPA effect on the inhibition of EGF binding to the cells due to the desensitization of protein kinase C; however, TNF still reduced the EGF binding to the cells pretreated with TPA for a long time.	Tetradecanoylphorbol Acetate	91-94	tumor necrosis factor	Homo sapiens	225-228
2334431-3	1990	Furthermore, prolonged incubation of WISH cells with 12-O-tetradecanoylphorbol 13 acetate (TPA) diminished the TPA effect on the inhibition of EGF binding to the cells due to the desensitization of protein kinase C; however, TNF still reduced the EGF binding to the cells pretreated with TPA for a long time.	Tetradecanoylphorbol Acetate	111-114	tumor necrosis factor	Homo sapiens	225-228
2334431-3	1990	Furthermore, prolonged incubation of WISH cells with 12-O-tetradecanoylphorbol 13 acetate (TPA) diminished the TPA effect on the inhibition of EGF binding to the cells due to the desensitization of protein kinase C; however, TNF still reduced the EGF binding to the cells pretreated with TPA for a long time.	Tetradecanoylphorbol Acetate	111-114	tumor necrosis factor	Homo sapiens	225-228
2321243-1	1990	We have studied the effects of the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) on cytochrome P-450-dependent monooxygenase activities in several differentiated and dedifferentiated Reuber rat hepatoma cell lines using aryl hydrocarbon (benzo[a]pyrene) hydroxylase (AHH), ethoxyresorufin O-deethylase (EROD), and aldrin epoxidase (AE) as test systems.	Tetradecanoylphorbol Acetate	50-86	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	96-112
2321243-1	1990	We have studied the effects of the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) on cytochrome P-450-dependent monooxygenase activities in several differentiated and dedifferentiated Reuber rat hepatoma cell lines using aryl hydrocarbon (benzo[a]pyrene) hydroxylase (AHH), ethoxyresorufin O-deethylase (EROD), and aldrin epoxidase (AE) as test systems.	Tetradecanoylphorbol Acetate	88-91	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	96-112
2109010-0	1990	Phorbol myristate acetate-induced down-modulation of CD4 is dependent on calmodulin and intracellular calcium.	Tetradecanoylphorbol Acetate	0-25	CD4 molecule	Homo sapiens	53-56
2138520-6	1990	A tumor-promoting phorbol ester, TPA, rendered TNF-sensitive and -insensitive EL4 cells resistant to M phi-mediated lysis.	Tetradecanoylphorbol Acetate	33-36	tumor necrosis factor	Mus musculus	47-50
2109010-10	1990	PMA-induced internalization of CD4 was blocked by Quin-2 AM, which chelates intracellular calcium.	Tetradecanoylphorbol Acetate	0-3	CD4 molecule	Homo sapiens	31-34
2138520-0	1990	TPA induction of EL4 resistance to macrophage-released TNF: role of ADP-ribosylation in tumoricidal activities of TNF and other factors.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Mus musculus	55-58
2138520-0	1990	TPA induction of EL4 resistance to macrophage-released TNF: role of ADP-ribosylation in tumoricidal activities of TNF and other factors.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Mus musculus	114-117
2156852-2	1990	The receptor for human urokinase-type plasminogen activator (u-PA) was purified from phorbol 12-myristate 13-acetate-stimulated U937 cells by temperature-induced phase separation of detergent extracts, followed by affinity chromatography with immobilized diisopropyl fluorophosphate-treated u-PA.	Tetradecanoylphorbol Acetate	85-116	plasminogen activator, urokinase	Homo sapiens	23-59
2156852-2	1990	The receptor for human urokinase-type plasminogen activator (u-PA) was purified from phorbol 12-myristate 13-acetate-stimulated U937 cells by temperature-induced phase separation of detergent extracts, followed by affinity chromatography with immobilized diisopropyl fluorophosphate-treated u-PA.	Tetradecanoylphorbol Acetate	85-116	plasminogen activator, urokinase	Homo sapiens	61-65
2138520-7	1990	However, TPA down-regulated TNF-specific binding sites on both TNF-sensitive and -resistant cell surface membranes, suggesting that resistance to TNF involves postligand:receptor events.	Tetradecanoylphorbol Acetate	9-12	tumor necrosis factor	Mus musculus	28-31
2138520-7	1990	However, TPA down-regulated TNF-specific binding sites on both TNF-sensitive and -resistant cell surface membranes, suggesting that resistance to TNF involves postligand:receptor events.	Tetradecanoylphorbol Acetate	9-12	tumor necrosis factor	Mus musculus	63-66
2138520-7	1990	However, TPA down-regulated TNF-specific binding sites on both TNF-sensitive and -resistant cell surface membranes, suggesting that resistance to TNF involves postligand:receptor events.	Tetradecanoylphorbol Acetate	9-12	tumor necrosis factor	Mus musculus	63-66
2327658-6	1990	Lipopolysaccharide, phorbol myristate acetate, and zymosan suppressed Fn release from AM but stimulated their PGE2 release, and these effects were reversed by indomethacin.	Tetradecanoylphorbol Acetate	20-45	fibronectin 1	Homo sapiens	70-72
2107881-3	1990	Pretreatment of hepatocytes with PMA for 5-15 min had little effect on the subsequent actions of 100 nM vasopressin but abolished the stimulation of inositol phosphate accumulation by 3 nM vasopressin and 20 microM norepinephrine.	Tetradecanoylphorbol Acetate	33-36	arginine vasopressin	Rattus norvegicus	189-200
2107881-4	1990	Long-term exposure (2-18 h) of hepatocytes to 1 microM PMA actually enhanced the effects of vasopressin and 20 microM norepinephrine.	Tetradecanoylphorbol Acetate	55-58	arginine vasopressin	Rattus norvegicus	92-103
2330986-5	1990	Pretreatment with PMA or with sphingosine each attenuated by approximately one-third the bicarbonate absorptive response usually observed following angiotensin II administration.	Tetradecanoylphorbol Acetate	18-21	angiotensinogen	Rattus norvegicus	148-162
2333947-7	1990	Temporally, the maximal stimulation of PKC translocation by mezerein, teleocidin A, and TPA preceded their ability to stimulate maximal 125I-ANG II-specific binding.	Tetradecanoylphorbol Acetate	88-91	angiotensinogen	Rattus norvegicus	141-147
2333947-5	1990	The PKC antagonist H-7 dose dependently inhibited phorbol 12-myristate 13-acetate (TPA)-stimulated increases in 125I-ANG II binding, whereas downregulation of PKC activity by chronic phorbol ester incubations of 24 and 48 h prevented TPA-stimulated increases in 125I-ANG II-specific binding.	Tetradecanoylphorbol Acetate	50-81	angiotensinogen	Rattus norvegicus	117-123
2333947-5	1990	The PKC antagonist H-7 dose dependently inhibited phorbol 12-myristate 13-acetate (TPA)-stimulated increases in 125I-ANG II binding, whereas downregulation of PKC activity by chronic phorbol ester incubations of 24 and 48 h prevented TPA-stimulated increases in 125I-ANG II-specific binding.	Tetradecanoylphorbol Acetate	50-81	angiotensinogen	Rattus norvegicus	267-273
2333947-5	1990	The PKC antagonist H-7 dose dependently inhibited phorbol 12-myristate 13-acetate (TPA)-stimulated increases in 125I-ANG II binding, whereas downregulation of PKC activity by chronic phorbol ester incubations of 24 and 48 h prevented TPA-stimulated increases in 125I-ANG II-specific binding.	Tetradecanoylphorbol Acetate	83-86	angiotensinogen	Rattus norvegicus	117-123
2333947-5	1990	The PKC antagonist H-7 dose dependently inhibited phorbol 12-myristate 13-acetate (TPA)-stimulated increases in 125I-ANG II binding, whereas downregulation of PKC activity by chronic phorbol ester incubations of 24 and 48 h prevented TPA-stimulated increases in 125I-ANG II-specific binding.	Tetradecanoylphorbol Acetate	83-86	angiotensinogen	Rattus norvegicus	267-273
2187453-10	1990	After 3 months of treatment, whole blood CL responses to Con-A and FMLP returned to almost normal levels in patients treated with Cy-A (15 cases) but not in those receiving the placebo (17 cases); PMA-induced CL responses were also decreased, but this was found in both groups of patients.	Tetradecanoylphorbol Acetate	197-200	formyl peptide receptor 1	Homo sapiens	67-71
2317558-3	1990	Regulated secretion of stored vWF induced by thrombin or phorbol-12-myristate-13-acetate (PMA) was also diminished in vWD cells.	Tetradecanoylphorbol Acetate	57-88	von Willebrand factor	Homo sapiens	30-33
2317558-3	1990	Regulated secretion of stored vWF induced by thrombin or phorbol-12-myristate-13-acetate (PMA) was also diminished in vWD cells.	Tetradecanoylphorbol Acetate	90-93	von Willebrand factor	Homo sapiens	30-33
1969920-4	1990	In contrast, IB4 completely inhibited PMA-stimulated PMN adherence to gelatin, fibronectin, collagen IV, and endothelial cell monolayers.	Tetradecanoylphorbol Acetate	38-41	fibronectin 1	Homo sapiens	79-90
1690769-6	1990	The association of the latter with PMA strongly induced the production of IL-2 on this cell model while either L161 or PMA alone had no effect.	Tetradecanoylphorbol Acetate	35-38	interleukin 2	Homo sapiens	74-78
2138707-0	1990	mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element.	Tetradecanoylphorbol Acetate	84-120	activating transcription factor 2	Mus musculus	0-4
1690989-1	1990	Treatment of HL-60 cells with 12-O-tetradecanoyl-phorbol 13-acetate (TPA) for 48 h induced expression of mRNA of beta A chain of activin A/erythroid differentiation factor.	Tetradecanoylphorbol Acetate	30-67	inhibin subunit beta A	Homo sapiens	139-171
2111570-5	1990	The phospholipase A2 inhibitor quinacrine was able to prevent the TPA-induced increase in PGE2 synthesis even in the presence of exogenous arachidonic acid suggesting that phospholipase A2 may be a target for PKC action.	Tetradecanoylphorbol Acetate	66-69	phospholipase A2 group IB	Homo sapiens	4-20
2111570-5	1990	The phospholipase A2 inhibitor quinacrine was able to prevent the TPA-induced increase in PGE2 synthesis even in the presence of exogenous arachidonic acid suggesting that phospholipase A2 may be a target for PKC action.	Tetradecanoylphorbol Acetate	66-69	phospholipase A2 group IB	Homo sapiens	172-188
2138707-8	1990	mXBP-c-Jun complexes can coexist with c-Fos-c-Jun complexes and can bind with high affinity to CRE, but not to TPA response DNA element, sequences.	Tetradecanoylphorbol Acetate	111-114	activating transcription factor 2	Mus musculus	0-4
1690989-6	1990	These results indicate that interferon-gamma has a priming effect on the activation of activin A/erythroid differentiation factor gene by TPA or LPS in HL-60 cells.	Tetradecanoylphorbol Acetate	138-141	interferon gamma	Homo sapiens	28-44
1690989-6	1990	These results indicate that interferon-gamma has a priming effect on the activation of activin A/erythroid differentiation factor gene by TPA or LPS in HL-60 cells.	Tetradecanoylphorbol Acetate	138-141	inhibin subunit beta A	Homo sapiens	97-129
1690989-1	1990	Treatment of HL-60 cells with 12-O-tetradecanoyl-phorbol 13-acetate (TPA) for 48 h induced expression of mRNA of beta A chain of activin A/erythroid differentiation factor.	Tetradecanoylphorbol Acetate	69-72	inhibin subunit beta A	Homo sapiens	139-171
1690989-3	1990	Furthermore, 4 h-treatment with TPA or lipopolysaccharide (LPS) induced a marked increase in beta A chain mRNA levels in interferon-gamma-pretreated HL-60 cells.	Tetradecanoylphorbol Acetate	32-35	interferon gamma	Homo sapiens	121-137
2105842-4	1990	Immunohistochemistry and time-kinetic studies on mRNA levels in mouse epidermis showed that the increase in MT and VL30 RNAs coincide in time with a TPA-induced transient block in basal cell proliferation (3-12 h after TPA treatment).	Tetradecanoylphorbol Acetate	149-152	RIKEN cDNA A130040M12 gene	Mus musculus	115-119
1969746-5	1990	The results provide a molecular basis whereby non-cytokine-mediated stimuli (e.g. TPA) alter KC signal transduction events involving protein kinase-C (PK-C) and thereby generate such immunologically relevant events as ICAM-I expression.	Tetradecanoylphorbol Acetate	82-85	proline rich transmembrane protein 2	Homo sapiens	133-149
1969746-5	1990	The results provide a molecular basis whereby non-cytokine-mediated stimuli (e.g. TPA) alter KC signal transduction events involving protein kinase-C (PK-C) and thereby generate such immunologically relevant events as ICAM-I expression.	Tetradecanoylphorbol Acetate	82-85	proline rich transmembrane protein 2	Homo sapiens	151-155
1969746-6	1990	Thus, KCs may be targets for both T-cell derived cytokines (e.g. IFN-gamma), and non-cytokine TPA-like molecules which stimulate PK-C.	Tetradecanoylphorbol Acetate	94-97	proline rich transmembrane protein 2	Homo sapiens	129-133
2105854-0	1990	IL-2, IL-6, and IFN-gamma have distinct effects on the IL-4 plus PMA-induced proliferation of thymocyte subpopulations.	Tetradecanoylphorbol Acetate	65-68	interleukin 6	Mus musculus	6-10
2105842-4	1990	Immunohistochemistry and time-kinetic studies on mRNA levels in mouse epidermis showed that the increase in MT and VL30 RNAs coincide in time with a TPA-induced transient block in basal cell proliferation (3-12 h after TPA treatment).	Tetradecanoylphorbol Acetate	219-222	RIKEN cDNA A130040M12 gene	Mus musculus	115-119
2105854-0	1990	IL-2, IL-6, and IFN-gamma have distinct effects on the IL-4 plus PMA-induced proliferation of thymocyte subpopulations.	Tetradecanoylphorbol Acetate	65-68	interferon gamma	Mus musculus	16-25
2129223-4	1990	The ability of Et-1 to stimulate both DNA synthesis and anchorage-independent growth was markedly reduced by the depletion of cellular pkC activity induced by prolonged exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	181-217	endothelin 1	Rattus norvegicus	15-19
2105842-6	1990	Treatment with other types of tumor promoters showed that MT-I and MT-II mRNAs were coordinately induced and indicated that sn-1,2-dioctanoylglycerol, 12-O-retinoylphorbol-13-acetate, and mezerein induced MT to a lesser degree than TPA.	Tetradecanoylphorbol Acetate	232-235	metallothionein 1	Mus musculus	58-62
2129223-4	1990	The ability of Et-1 to stimulate both DNA synthesis and anchorage-independent growth was markedly reduced by the depletion of cellular pkC activity induced by prolonged exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	219-222	endothelin 1	Rattus norvegicus	15-19
2107991-5	1990	Reduced IFN-gamma secretion was observed after stimulation with the CD3 monoclonal antibody OKT3, ionomycin + 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or with high levels of IL-2 (200 U/ml).	Tetradecanoylphorbol Acetate	110-147	interferon gamma	Homo sapiens	8-17
2105842-6	1990	Treatment with other types of tumor promoters showed that MT-I and MT-II mRNAs were coordinately induced and indicated that sn-1,2-dioctanoylglycerol, 12-O-retinoylphorbol-13-acetate, and mezerein induced MT to a lesser degree than TPA.	Tetradecanoylphorbol Acetate	232-235	metallothionein 2	Mus musculus	67-72
2107991-5	1990	Reduced IFN-gamma secretion was observed after stimulation with the CD3 monoclonal antibody OKT3, ionomycin + 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or with high levels of IL-2 (200 U/ml).	Tetradecanoylphorbol Acetate	149-152	interferon gamma	Homo sapiens	8-17
2105842-8	1990	VL30 and MT mRNA levels were not found to be elevated in epidermal tumors whereas the mRNA level corresponding to glyceraldehyde-3-phosphate dehydrogenase was elevated in tumors and induced by TPA with time-kinetics that correlate with a TPA-induced hyperproliferation.	Tetradecanoylphorbol Acetate	193-196	RIKEN cDNA A130040M12 gene	Mus musculus	0-4
2307938-4	1990	FACS analysis of highly purified normal human T cells labeled with an anti-TNF mAb revealed that T cells express cell surface TNF when signaled with the synergistic combination of a calcium ionophore, ionomycin, and a protein kinase C activator, 12-o-tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	246-280	tumor necrosis factor	Homo sapiens	75-78
2188740-5	1990	Upon exposure to TPA the cells spread on a growth substratum covered with human plasma fibronectin (Fn).	Tetradecanoylphorbol Acetate	17-20	fibronectin 1	Homo sapiens	87-98
2307845-9	1990	THP-1 cells express low levels of an abnormally sized mRNA for PAI-2 and demonstrate a regulatory defect whereby steady state levels of PAI-2 mRNA are markedly reduced upon stimulation with PMA or LPS.	Tetradecanoylphorbol Acetate	190-193	GLI family zinc finger 2	Homo sapiens	0-5
1974593-3	1990	The ability of the phorbol ester, phorbol 12-myristate 13-acetate (PMA), and the calcium ionophore, A23187, in co-stimulation with PHA, to enhance the IL-2 secretion, IL-2R expression and 3H thymidine incorporation were studied in the PBMC of colorectal cancer patients.	Tetradecanoylphorbol Acetate	34-65	interleukin 2	Homo sapiens	151-155
1974593-3	1990	The ability of the phorbol ester, phorbol 12-myristate 13-acetate (PMA), and the calcium ionophore, A23187, in co-stimulation with PHA, to enhance the IL-2 secretion, IL-2R expression and 3H thymidine incorporation were studied in the PBMC of colorectal cancer patients.	Tetradecanoylphorbol Acetate	67-70	interleukin 2	Homo sapiens	151-155
1974593-7	1990	A23187 is known to be effective in elevating cytosolic free Ca2+ and PMA is regarded as an activator of protein kinase C. Therefore, we may conclude that the impairment of IL-2 production and IL-2R expression in PHA-stimulated cultures is mainly due to failure of the free Ca2+ release which can be repaired by A23187.	Tetradecanoylphorbol Acetate	69-72	interleukin 2	Homo sapiens	172-176
2307938-4	1990	FACS analysis of highly purified normal human T cells labeled with an anti-TNF mAb revealed that T cells express cell surface TNF when signaled with the synergistic combination of a calcium ionophore, ionomycin, and a protein kinase C activator, 12-o-tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	246-280	tumor necrosis factor	Homo sapiens	126-129
2106348-4	1990	Of the enzymes involved in the availability and metabolism of arachidonic acid, phospholipase A2 activity was increased 2-fold in the membranes of TPA-differentiated U937 cells, whereas lysophosphatide acyltransferase activity remained unaltered.	Tetradecanoylphorbol Acetate	147-150	phospholipase A2 group IB	Homo sapiens	80-96
2160601-5	1990	Treatment of cells for 24-48 h with combinations of NGF, forskolin to elevate cAMP levels, and phorbol-12-myristate-13-acetate (PMA) to activate protein kinase C synergistically elevated NPY mRNA levels.	Tetradecanoylphorbol Acetate	95-126	neuropeptide Y	Rattus norvegicus	187-190
2160601-5	1990	Treatment of cells for 24-48 h with combinations of NGF, forskolin to elevate cAMP levels, and phorbol-12-myristate-13-acetate (PMA) to activate protein kinase C synergistically elevated NPY mRNA levels.	Tetradecanoylphorbol Acetate	128-131	neuropeptide Y	Rattus norvegicus	187-190
2160601-6	1990	The rate of NPY gene transcription in PC12 nuclei was increased by NGF, forskolin plus PMA, or NGF plus forskolin plus PMA, indicating that these regulators act at least in part at a transcriptional level.	Tetradecanoylphorbol Acetate	87-90	neuropeptide Y	Rattus norvegicus	12-15
2154481-2	1990	We here report that the phorbol ester phorbol 12-myristate 13-acetate (PMA) mimics all ACTH-specific effects in Y-1 cells, namely: (a) steroid-ogenesis stimulation, (b) cell cycle block, and (c) cell shape change.	Tetradecanoylphorbol Acetate	38-69	proopiomelanocortin	Homo sapiens	87-91
1689353-5	1990	RAP potentiated the effect of CsA on proliferation and IL-2R expression in T cells stimulated with ionomycin + PMA.	Tetradecanoylphorbol Acetate	111-114	regulatory associated protein of MTOR, complex 1	Mus musculus	0-3
2154481-2	1990	We here report that the phorbol ester phorbol 12-myristate 13-acetate (PMA) mimics all ACTH-specific effects in Y-1 cells, namely: (a) steroid-ogenesis stimulation, (b) cell cycle block, and (c) cell shape change.	Tetradecanoylphorbol Acetate	71-74	proopiomelanocortin	Homo sapiens	87-91
2155825-0	1990	Potentiation of angiotensin II-stimulated phosphoinositide hydrolysis, calcium mobilization and contraction of renal mesangial cells upon down-regulation of protein kinase C. Long-term pretreatment of rat mesangial cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) down-regulated protein kinase C activity and potentiated the angiotensin II-induced inositol trisphosphate (InsP3) formation.	Tetradecanoylphorbol Acetate	226-262	angiotensinogen	Rattus norvegicus	16-30
2155825-0	1990	Potentiation of angiotensin II-stimulated phosphoinositide hydrolysis, calcium mobilization and contraction of renal mesangial cells upon down-regulation of protein kinase C. Long-term pretreatment of rat mesangial cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) down-regulated protein kinase C activity and potentiated the angiotensin II-induced inositol trisphosphate (InsP3) formation.	Tetradecanoylphorbol Acetate	264-267	angiotensinogen	Rattus norvegicus	16-30
2310766-9	1990	However, incubation of cells with TPA did not significantly modify chromogranin A processing, indicating that biosynthesis and proteolytic processing of chromogranin A are two distinctly regulated mechanisms.	Tetradecanoylphorbol Acetate	34-37	chromogranin A	Bos taurus	153-167
2155825-3	1990	Long-term pretreatment with TPA also increased the angiotensin II-induced mobilization of Ca2+ and the subsequent contraction of mesangial cells.	Tetradecanoylphorbol Acetate	28-31	angiotensinogen	Rattus norvegicus	51-65
2137493-7	1990	The inhibition of CD43-mediated signaling by PMA was due, in part, to uncoupling of CD43 from the signal-transducing G protein.	Tetradecanoylphorbol Acetate	45-48	sialophorin	Homo sapiens	18-22
2153711-5	1990	Half of the variants defective in O-2 production after phorbol myristate acetate stimulation were also resistant to the antiproliferative effects of IFN-gamma.	Tetradecanoylphorbol Acetate	55-80	interferon gamma	Mus musculus	149-158
2137493-7	1990	The inhibition of CD43-mediated signaling by PMA was due, in part, to uncoupling of CD43 from the signal-transducing G protein.	Tetradecanoylphorbol Acetate	45-48	sialophorin	Homo sapiens	84-88
2137493-11	1990	Staurosporine, a potent inhibitor of PKC, abrogated the hyperphosphorylation of CD43 and normalized CD43-mediated signaling in PMA-treated cells.	Tetradecanoylphorbol Acetate	127-130	sialophorin	Homo sapiens	100-104
2105315-10	1990	At the same position as the cAMP-responsive element in the rat gene, the mouse and human tPA genes have a 12-O-tetradecanoylphorbol-13-acetate-responsive element known to mediate activation by phorbol esters.	Tetradecanoylphorbol Acetate	106-142	plasminogen activator, tissue type	Homo sapiens	89-92
2111191-1	1990	The treatment of human tonsillar T-lymphocytes with 4-phorbol 12-myristate 13-acetate (PMA), resulted in about two fold increase in glucocorticoid receptor (GR) number, without any significant change in the receptor affinity.	Tetradecanoylphorbol Acetate	87-90	nuclear receptor subfamily 3 group C member 1	Homo sapiens	132-155
2111191-1	1990	The treatment of human tonsillar T-lymphocytes with 4-phorbol 12-myristate 13-acetate (PMA), resulted in about two fold increase in glucocorticoid receptor (GR) number, without any significant change in the receptor affinity.	Tetradecanoylphorbol Acetate	87-90	nuclear receptor subfamily 3 group C member 1	Homo sapiens	157-159
2306265-0	1990	Effects of hepatic peroxisome proliferators and 12-O-tetradecanoyl phorbol-13-acetate on catalase and other enzyme activities of embryonic cells in vitro.	Tetradecanoylphorbol Acetate	48-85	catalase	Rattus norvegicus	89-97
2306265-11	1990	2,4-D and TPA induced no or only a very slight increase in the catalase activity.	Tetradecanoylphorbol Acetate	10-13	catalase	Rattus norvegicus	63-71
2105883-1	1990	CD4, the T cell surface antigen, is phosphorylated and internalized when T cells are activated or treated with a phorbol ester, PMA.	Tetradecanoylphorbol Acetate	128-131	CD4 molecule	Homo sapiens	0-3
2407643-5	1990	Attachment of the patient"s IgA to the 62,000 MW protein activated intracellular oxidative metabolism on a parity with phorbol myristate acetate (PMA) and resulted in a significant up-regulation of membrane receptors for FMLP.	Tetradecanoylphorbol Acetate	119-144	CD79a molecule	Homo sapiens	28-31
2407643-5	1990	Attachment of the patient"s IgA to the 62,000 MW protein activated intracellular oxidative metabolism on a parity with phorbol myristate acetate (PMA) and resulted in a significant up-regulation of membrane receptors for FMLP.	Tetradecanoylphorbol Acetate	146-149	CD79a molecule	Homo sapiens	28-31
2323487-1	1990	Previous studies, involving phosphorylation of cytoplasmic proteins and localization of DNA regulatory elements, have suggested that epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) have similar actions on prolactin (PRL) gene expression by pituitary (GH) cells.	Tetradecanoylphorbol Acetate	167-203	prolactin	Rattus norvegicus	234-243
2323487-1	1990	Previous studies, involving phosphorylation of cytoplasmic proteins and localization of DNA regulatory elements, have suggested that epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) have similar actions on prolactin (PRL) gene expression by pituitary (GH) cells.	Tetradecanoylphorbol Acetate	167-203	prolactin	Rattus norvegicus	245-248
2323487-1	1990	Previous studies, involving phosphorylation of cytoplasmic proteins and localization of DNA regulatory elements, have suggested that epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) have similar actions on prolactin (PRL) gene expression by pituitary (GH) cells.	Tetradecanoylphorbol Acetate	205-208	prolactin	Rattus norvegicus	234-243
2323487-1	1990	Previous studies, involving phosphorylation of cytoplasmic proteins and localization of DNA regulatory elements, have suggested that epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) have similar actions on prolactin (PRL) gene expression by pituitary (GH) cells.	Tetradecanoylphorbol Acetate	205-208	prolactin	Rattus norvegicus	245-248
2323487-4	1990	Chronic exposure of GH3 cells to TPA, which strongly down-regulates protein kinase C activity, completely inhibited acute TPA stimulation of transient expression of a transfected PRL promoter construct ((-187)PRL-CAT), but did not inhibit EGF stimulation of either accumulation of endogenous PRL mRNA or of expression of (-187)PRL-CAT.	Tetradecanoylphorbol Acetate	33-36	prolactin	Rattus norvegicus	179-182
2323487-4	1990	Chronic exposure of GH3 cells to TPA, which strongly down-regulates protein kinase C activity, completely inhibited acute TPA stimulation of transient expression of a transfected PRL promoter construct ((-187)PRL-CAT), but did not inhibit EGF stimulation of either accumulation of endogenous PRL mRNA or of expression of (-187)PRL-CAT.	Tetradecanoylphorbol Acetate	33-36	prolactin	Rattus norvegicus	209-212
2323487-4	1990	Chronic exposure of GH3 cells to TPA, which strongly down-regulates protein kinase C activity, completely inhibited acute TPA stimulation of transient expression of a transfected PRL promoter construct ((-187)PRL-CAT), but did not inhibit EGF stimulation of either accumulation of endogenous PRL mRNA or of expression of (-187)PRL-CAT.	Tetradecanoylphorbol Acetate	33-36	prolactin	Rattus norvegicus	209-212
2323487-4	1990	Chronic exposure of GH3 cells to TPA, which strongly down-regulates protein kinase C activity, completely inhibited acute TPA stimulation of transient expression of a transfected PRL promoter construct ((-187)PRL-CAT), but did not inhibit EGF stimulation of either accumulation of endogenous PRL mRNA or of expression of (-187)PRL-CAT.	Tetradecanoylphorbol Acetate	33-36	prolactin	Rattus norvegicus	209-212
2323487-4	1990	Chronic exposure of GH3 cells to TPA, which strongly down-regulates protein kinase C activity, completely inhibited acute TPA stimulation of transient expression of a transfected PRL promoter construct ((-187)PRL-CAT), but did not inhibit EGF stimulation of either accumulation of endogenous PRL mRNA or of expression of (-187)PRL-CAT.	Tetradecanoylphorbol Acetate	122-125	prolactin	Rattus norvegicus	179-182
2307713-6	1990	Several independent assays suggested that the inhibition of EGF-receptor activity was independent of protein kinase C modulation as mediated by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	144-169	epidermal growth factor receptor	Homo sapiens	60-72
2407742-7	1990	However, the ability of TPA-treatment to inhibit bradykinin-stimulated phosphoinositide hydrolysis and enhance bradykinin-stimulated AA release was attenuated in MDCK-RAS.	Tetradecanoylphorbol Acetate	24-27	kininogen 1	Canis lupus familiaris	49-59
2407742-7	1990	However, the ability of TPA-treatment to inhibit bradykinin-stimulated phosphoinositide hydrolysis and enhance bradykinin-stimulated AA release was attenuated in MDCK-RAS.	Tetradecanoylphorbol Acetate	24-27	kininogen 1	Canis lupus familiaris	111-121
2323487-4	1990	Chronic exposure of GH3 cells to TPA, which strongly down-regulates protein kinase C activity, completely inhibited acute TPA stimulation of transient expression of a transfected PRL promoter construct ((-187)PRL-CAT), but did not inhibit EGF stimulation of either accumulation of endogenous PRL mRNA or of expression of (-187)PRL-CAT.	Tetradecanoylphorbol Acetate	122-125	prolactin	Rattus norvegicus	209-212
2323487-4	1990	Chronic exposure of GH3 cells to TPA, which strongly down-regulates protein kinase C activity, completely inhibited acute TPA stimulation of transient expression of a transfected PRL promoter construct ((-187)PRL-CAT), but did not inhibit EGF stimulation of either accumulation of endogenous PRL mRNA or of expression of (-187)PRL-CAT.	Tetradecanoylphorbol Acetate	122-125	prolactin	Rattus norvegicus	209-212
2323487-4	1990	Chronic exposure of GH3 cells to TPA, which strongly down-regulates protein kinase C activity, completely inhibited acute TPA stimulation of transient expression of a transfected PRL promoter construct ((-187)PRL-CAT), but did not inhibit EGF stimulation of either accumulation of endogenous PRL mRNA or of expression of (-187)PRL-CAT.	Tetradecanoylphorbol Acetate	122-125	prolactin	Rattus norvegicus	209-212
2323487-5	1990	Furthermore, the acute stimulatory effects of EGF and TPA on expression of (-187)PRL-CAT were additive.	Tetradecanoylphorbol Acetate	54-57	prolactin	Rattus norvegicus	81-84
2323487-6	1990	Each of these observations implies that EGF and TPA have gene-distal actions on PRL gene expression that are at least partially non-overlapping.	Tetradecanoylphorbol Acetate	48-51	prolactin	Rattus norvegicus	80-83
2154205-5	1990	Angiotensin II- and bradykinin-stimulated inositol phosphate accumulation in intact glomeruli was inhibited by phorbol myristate acetate, an activator of protein kinase C.	Tetradecanoylphorbol Acetate	111-136	angiotensinogen	Rattus norvegicus	0-14
2302234-2	1990	This biological unresponsiveness of MCF-7:RPh-4 cells to phorbol esters seems to be unrelated to activation of protein kinase C. In the presence of 80 nM PMA (12-O-tetradecanoylphorbol-13-acetate), TGF-beta induced a dose-dependent inhibition of MCF-7:RPh-4 cell proliferation.	Tetradecanoylphorbol Acetate	154-157	transforming growth factor beta 1	Homo sapiens	198-206
2302234-2	1990	This biological unresponsiveness of MCF-7:RPh-4 cells to phorbol esters seems to be unrelated to activation of protein kinase C. In the presence of 80 nM PMA (12-O-tetradecanoylphorbol-13-acetate), TGF-beta induced a dose-dependent inhibition of MCF-7:RPh-4 cell proliferation.	Tetradecanoylphorbol Acetate	159-195	transforming growth factor beta 1	Homo sapiens	198-206
2302234-4	1990	Under these conditions, addition of 80 nM PMA restored sensitivity to TGF-beta.	Tetradecanoylphorbol Acetate	42-45	transforming growth factor beta 1	Homo sapiens	70-78
2336792-8	1990	It was observed that coincubation of PMA with PAF, or A23187 resulted in an inhibition of beta-glucuronidase secretion and an enhancement of myeloperoxidase secretion, respectively.	Tetradecanoylphorbol Acetate	37-40	beta-glucuronidase	Bos taurus	90-108
2153128-7	1990	Exposure of CEF and RSV-CEF for 24 h to the protein kinase C activating agent phorbol myristate acetate (PMA) increased cellular uPA mRNA levels to 20 and 260 molecules/cell, respectively.	Tetradecanoylphorbol Acetate	78-103	plasminogen activator, urokinase	Homo sapiens	129-132
2153128-7	1990	Exposure of CEF and RSV-CEF for 24 h to the protein kinase C activating agent phorbol myristate acetate (PMA) increased cellular uPA mRNA levels to 20 and 260 molecules/cell, respectively.	Tetradecanoylphorbol Acetate	105-108	plasminogen activator, urokinase	Homo sapiens	129-132
2295806-1	1990	12-O-Tetradecanoylphorbol-13-acetate (TPA), a tumor-promoting phorbol ester, induced the proliferation of connective tissue-type mast cells (CTMC) synergistically with IL-3 in a methylcellulose culture, as well as with IL-4.	Tetradecanoylphorbol Acetate	0-36	interleukin 4	Homo sapiens	219-223
2297525-6	1990	Peroxisomal beta-oxidation was increased about 2-fold in the peroxisome-enriched fraction of TPA-treated rats while the catalase and urate oxidase activities were only marginally affected.	Tetradecanoylphorbol Acetate	93-96	catalase	Rattus norvegicus	120-128
2295806-1	1990	12-O-Tetradecanoylphorbol-13-acetate (TPA), a tumor-promoting phorbol ester, induced the proliferation of connective tissue-type mast cells (CTMC) synergistically with IL-3 in a methylcellulose culture, as well as with IL-4.	Tetradecanoylphorbol Acetate	38-41	interleukin 4	Homo sapiens	219-223
2081097-5	1990	The down-regulation of PKC activity in these quiescent cells by prolonged exposure to TPA strongly inhibited the ability of the reactivated v-src protein to stimulate DNA replication in serum-deficient medium, suggesting that PKC plays a role in the initial signal by which the viral enzyme induces the G0 to G1 transition in NRK cells.	Tetradecanoylphorbol Acetate	86-89	proline rich transmembrane protein 2	Homo sapiens	23-26
2119652-3	1990	It is known that treatment of a cell with 12-0-tetradecanoylphorbol 13-acetate (TPA) causes down-regulation of PK-C, and that calpain can cleave PK-C into catalytic and regulatory fragments in vitro.	Tetradecanoylphorbol Acetate	80-83	proline rich transmembrane protein 2	Homo sapiens	111-115
2119652-3	1990	It is known that treatment of a cell with 12-0-tetradecanoylphorbol 13-acetate (TPA) causes down-regulation of PK-C, and that calpain can cleave PK-C into catalytic and regulatory fragments in vitro.	Tetradecanoylphorbol Acetate	80-83	proline rich transmembrane protein 2	Homo sapiens	145-149
2119652-5	1990	TPA-dependent down-regulation of PK-C was partially inhibited by pre-treatment with calpastatin peptide and inhibitors, suggesting in vivo involvement of calpain in down-regulation of PK-C during signal transduction.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	33-37
2119652-5	1990	TPA-dependent down-regulation of PK-C was partially inhibited by pre-treatment with calpastatin peptide and inhibitors, suggesting in vivo involvement of calpain in down-regulation of PK-C during signal transduction.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	184-188
1973607-5	1990	PBLs of 18 BP patients showed an increase in IL2 production (1027.4 +/- 670.5 U/ml vs 270 +/- 100 U/ml in controls) during the acute stage of the disease after stimulation with phytohaemagglutinin (PHA)/phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	203-228	interleukin 2	Homo sapiens	45-48
1973607-5	1990	PBLs of 18 BP patients showed an increase in IL2 production (1027.4 +/- 670.5 U/ml vs 270 +/- 100 U/ml in controls) during the acute stage of the disease after stimulation with phytohaemagglutinin (PHA)/phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	230-233	interleukin 2	Homo sapiens	45-48
2176783-2	1990	A simple, rapid and inexpensive method (o-DD method) is described for the measurement of hydrogen peroxide released by human polymorphonuclear leukocytes (PMNL) stimulated with phorbol myristate acetate (PMA), n-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A).	Tetradecanoylphorbol Acetate	204-207	formyl peptide receptor 1	Homo sapiens	251-255
2081097-5	1990	The down-regulation of PKC activity in these quiescent cells by prolonged exposure to TPA strongly inhibited the ability of the reactivated v-src protein to stimulate DNA replication in serum-deficient medium, suggesting that PKC plays a role in the initial signal by which the viral enzyme induces the G0 to G1 transition in NRK cells.	Tetradecanoylphorbol Acetate	86-89	proline rich transmembrane protein 2	Homo sapiens	226-229
2293979-5	1990	Incubation of the cells with 100 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in transient translocation of PKC activity to the membrane (15 min) which was followed by a 64% decrease in total cellular enzyme activity after 3 h. In PKC-depleted cells, the aldosterone response to ACTH was increased by 25% but AII-stimulated steroidogenesis was unchanged.	Tetradecanoylphorbol Acetate	36-72	angiotensinogen	Rattus norvegicus	319-322
2225720-6	1990	N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide W-7, a putative calmodulin antagonist, inhibited TPA-induced PGE2 release at concentrations regarded specific for blocking calmodulin (IC50 = 1.5 X 0(-6) M).	Tetradecanoylphorbol Acetate	101-104	calmodulin 1	Homo sapiens	68-78
2225720-6	1990	N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide W-7, a putative calmodulin antagonist, inhibited TPA-induced PGE2 release at concentrations regarded specific for blocking calmodulin (IC50 = 1.5 X 0(-6) M).	Tetradecanoylphorbol Acetate	101-104	calmodulin 1	Homo sapiens	175-185
2294005-5	1990	IL-6 production was stimulated by phorbol myristate acetate (10-100 nM) approximately 2-fold and by lipopolysaccharide (0.001-10.0 micrograms/ml) 4-fold during 4-h incubations.	Tetradecanoylphorbol Acetate	34-59	interleukin 6	Homo sapiens	0-4
2293979-5	1990	Incubation of the cells with 100 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in transient translocation of PKC activity to the membrane (15 min) which was followed by a 64% decrease in total cellular enzyme activity after 3 h. In PKC-depleted cells, the aldosterone response to ACTH was increased by 25% but AII-stimulated steroidogenesis was unchanged.	Tetradecanoylphorbol Acetate	74-77	angiotensinogen	Rattus norvegicus	319-322
2293979-6	1990	In contrast, in cells in which PKC was translocated to the membrane by a 15 min preincubation with TPA, aldosterone response to AII was enhanced by 40%, while the response to ACTH was reduced by 30%; under these conditions membrane PKC levels rapidly returned to basal.	Tetradecanoylphorbol Acetate	99-102	angiotensinogen	Rattus norvegicus	128-131
2293979-7	1990	However, the changes in aldosterone response were still evident when addition of AII or ACTH was delayed for up to 30 min after removal of TPA, indicating a persistent modification in the cell membrane secondary to PKC activation.	Tetradecanoylphorbol Acetate	139-142	angiotensinogen	Rattus norvegicus	81-84
2293979-11	1990	However, the fact that aldosterone responses to AII are potentiated during TPA-induced PKC translocation to the membrane suggests that AII and phorbol esters do not share the same mechanism of action in the regulation of steroidogenesis.	Tetradecanoylphorbol Acetate	75-78	angiotensinogen	Rattus norvegicus	48-51
2293979-11	1990	However, the fact that aldosterone responses to AII are potentiated during TPA-induced PKC translocation to the membrane suggests that AII and phorbol esters do not share the same mechanism of action in the regulation of steroidogenesis.	Tetradecanoylphorbol Acetate	75-78	angiotensinogen	Rattus norvegicus	135-138
2097151-0	1990	Placental alkaline phosphatase (PLAP)/PLAP-like alkaline phosphatase as tumour marker in relation to CA 125 and TPA for ovarian epithelial tumours.	Tetradecanoylphorbol Acetate	112-115	alkaline phosphatase, placental	Homo sapiens	0-30
2150760-6	1990	In our experimental system, IL-2 production was observed either when L3T4-positive T cell hybridomas 2-45-12 were stimulated with ABA-L-Tyr and Ia molecules on the vesicles in the presence of phorbol 12-myristate 13-acetate, or when L3T4-negative T cell hybridomas 3H60.12 were incubated with ABA-L-Tyr and Ia molecules on the planar membranes.	Tetradecanoylphorbol Acetate	192-223	interleukin 2	Homo sapiens	28-32
2105908-6	1990	Although NF-kappa B cannot be activated by LPS, it can be activated by treatment with phorbol ester (PMA).	Tetradecanoylphorbol Acetate	101-104	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	9-19
2107143-2	1990	In this study, we demonstrate that the IL-2 secretion and cell proliferation of both human and mouse lymphocytes, and the production of CSF by mouse spleen cells, was significantly enhanced by the synergistic effect of AS101 and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	229-254	interleukin 2	Homo sapiens	39-43
2107143-2	1990	In this study, we demonstrate that the IL-2 secretion and cell proliferation of both human and mouse lymphocytes, and the production of CSF by mouse spleen cells, was significantly enhanced by the synergistic effect of AS101 and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	256-259	interleukin 2	Homo sapiens	39-43
2098371-1	1990	Human interferon-alpha (Hu-IFN alpha) and phorbol myristate acetate (PMA), a direct activator of protein kinase C (PK-C), induce the translocation of protein kinase C from the cytosol to the membrane fraction.	Tetradecanoylphorbol Acetate	42-67	proline rich transmembrane protein 2	Homo sapiens	97-113
2098371-1	1990	Human interferon-alpha (Hu-IFN alpha) and phorbol myristate acetate (PMA), a direct activator of protein kinase C (PK-C), induce the translocation of protein kinase C from the cytosol to the membrane fraction.	Tetradecanoylphorbol Acetate	42-67	proline rich transmembrane protein 2	Homo sapiens	115-119
2098371-1	1990	Human interferon-alpha (Hu-IFN alpha) and phorbol myristate acetate (PMA), a direct activator of protein kinase C (PK-C), induce the translocation of protein kinase C from the cytosol to the membrane fraction.	Tetradecanoylphorbol Acetate	42-67	proline rich transmembrane protein 2	Homo sapiens	150-166
2098371-1	1990	Human interferon-alpha (Hu-IFN alpha) and phorbol myristate acetate (PMA), a direct activator of protein kinase C (PK-C), induce the translocation of protein kinase C from the cytosol to the membrane fraction.	Tetradecanoylphorbol Acetate	69-72	proline rich transmembrane protein 2	Homo sapiens	97-113
2098371-1	1990	Human interferon-alpha (Hu-IFN alpha) and phorbol myristate acetate (PMA), a direct activator of protein kinase C (PK-C), induce the translocation of protein kinase C from the cytosol to the membrane fraction.	Tetradecanoylphorbol Acetate	69-72	proline rich transmembrane protein 2	Homo sapiens	115-119
2098371-1	1990	Human interferon-alpha (Hu-IFN alpha) and phorbol myristate acetate (PMA), a direct activator of protein kinase C (PK-C), induce the translocation of protein kinase C from the cytosol to the membrane fraction.	Tetradecanoylphorbol Acetate	69-72	proline rich transmembrane protein 2	Homo sapiens	150-166
1967263-10	1990	As was demonstrated in neutrophils, phosphorylation of the CD18 beta-chains of mononuclear cells was not constitutive but was induced in the presence of PMA and not FMLP.	Tetradecanoylphorbol Acetate	153-156	integrin subunit beta 2	Homo sapiens	59-63
2152940-5	1990	FMLP also markedly increased calcium/phospholipid-independent protein kinase activity in particulate fractions of control and PMA-treated cells.	Tetradecanoylphorbol Acetate	126-129	formyl peptide receptor 1	Homo sapiens	0-4
2133285-10	1990	PBM primed with PAF respond by secreting TNF to both phorbol myristate acetate and concanavalin A but respond poorly to PAF, LPS, or IFN-gamma.	Tetradecanoylphorbol Acetate	53-78	tumor necrosis factor	Homo sapiens	41-44
2319624-1	1990	Treatment with 300 nM phorbol 12-myristate 13-acetate (PMA) transforms polygonal-shaped cultured astrocytes into process-bearing cells and produces a shift in protein kinase C (PK-C) from the cytosol to the membrane.	Tetradecanoylphorbol Acetate	22-53	proline rich transmembrane protein 2	Homo sapiens	159-175
2293618-2	1990	It was found that neurite outgrowth induced by 12-O-tetradecanoylphorbol 13-acetate (TPA, 81 nM) was associated with a down-regulation of PKC as determined independently by immunocytochemistry, immunoblot, and enzyme activity assay.	Tetradecanoylphorbol Acetate	47-83	proline rich transmembrane protein 2	Homo sapiens	138-141
2319624-1	1990	Treatment with 300 nM phorbol 12-myristate 13-acetate (PMA) transforms polygonal-shaped cultured astrocytes into process-bearing cells and produces a shift in protein kinase C (PK-C) from the cytosol to the membrane.	Tetradecanoylphorbol Acetate	22-53	proline rich transmembrane protein 2	Homo sapiens	177-181
2293618-2	1990	It was found that neurite outgrowth induced by 12-O-tetradecanoylphorbol 13-acetate (TPA, 81 nM) was associated with a down-regulation of PKC as determined independently by immunocytochemistry, immunoblot, and enzyme activity assay.	Tetradecanoylphorbol Acetate	85-88	proline rich transmembrane protein 2	Homo sapiens	138-141
2293618-5	1990	Pretreatment of LA-N-5 cells with a high concentration (1 microM) of TPA to deplete cellular PKC rendered the cells unresponsive to the differentiating effect of the agents.	Tetradecanoylphorbol Acetate	69-72	proline rich transmembrane protein 2	Homo sapiens	93-96
2293618-7	1990	The present studies suggested that PKC and its 80-kilodalton substrate protein were likely involved in initiation and/or progression of LA-N-5 cell differentiation induced by TPA and that separate PKC-independent pathways might also be involved in the differentiating effect of retinoic acid or nerve growth factor.	Tetradecanoylphorbol Acetate	175-178	proline rich transmembrane protein 2	Homo sapiens	35-38
2319624-1	1990	Treatment with 300 nM phorbol 12-myristate 13-acetate (PMA) transforms polygonal-shaped cultured astrocytes into process-bearing cells and produces a shift in protein kinase C (PK-C) from the cytosol to the membrane.	Tetradecanoylphorbol Acetate	55-58	proline rich transmembrane protein 2	Homo sapiens	159-175
2319624-1	1990	Treatment with 300 nM phorbol 12-myristate 13-acetate (PMA) transforms polygonal-shaped cultured astrocytes into process-bearing cells and produces a shift in protein kinase C (PK-C) from the cytosol to the membrane.	Tetradecanoylphorbol Acetate	55-58	proline rich transmembrane protein 2	Homo sapiens	177-181
2319624-3	1990	The effects of PMA on the translocation of PK-C and on protein phosphorylation precede the PMA-induced changes in astrocyte morphology, and a close correlation exists between the concentration of PMA necessary to elicit half-maximal and maximal effects on the shift of PK-C to the membrane and on protein phosphorylation.	Tetradecanoylphorbol Acetate	15-18	proline rich transmembrane protein 2	Homo sapiens	43-47
2319624-3	1990	The effects of PMA on the translocation of PK-C and on protein phosphorylation precede the PMA-induced changes in astrocyte morphology, and a close correlation exists between the concentration of PMA necessary to elicit half-maximal and maximal effects on the shift of PK-C to the membrane and on protein phosphorylation.	Tetradecanoylphorbol Acetate	15-18	proline rich transmembrane protein 2	Homo sapiens	269-273
2319624-3	1990	The effects of PMA on the translocation of PK-C and on protein phosphorylation precede the PMA-induced changes in astrocyte morphology, and a close correlation exists between the concentration of PMA necessary to elicit half-maximal and maximal effects on the shift of PK-C to the membrane and on protein phosphorylation.	Tetradecanoylphorbol Acetate	91-94	proline rich transmembrane protein 2	Homo sapiens	43-47
2319624-3	1990	The effects of PMA on the translocation of PK-C and on protein phosphorylation precede the PMA-induced changes in astrocyte morphology, and a close correlation exists between the concentration of PMA necessary to elicit half-maximal and maximal effects on the shift of PK-C to the membrane and on protein phosphorylation.	Tetradecanoylphorbol Acetate	91-94	proline rich transmembrane protein 2	Homo sapiens	269-273
2319624-7	1990	The morphological responsiveness to PMA gradually returns in 5 to 8 days after the initial treatment with PMA, and this is accompanied by the recovery of PK-C activity and the phosphorylation response.	Tetradecanoylphorbol Acetate	36-39	proline rich transmembrane protein 2	Homo sapiens	154-158
2197510-3	1990	TPA-treated K562 cells also synthesize and secrete platelet derived growth factor (PDGF), transforming growth factor beta 1 (TGF beta 1), urokinase-plasminogen activator (u-PA) and its specific inhibitor, type 1 plasminogen activator inhibitor (PAI-1).	Tetradecanoylphorbol Acetate	0-3	transforming growth factor beta 1	Homo sapiens	90-123
2197510-3	1990	TPA-treated K562 cells also synthesize and secrete platelet derived growth factor (PDGF), transforming growth factor beta 1 (TGF beta 1), urokinase-plasminogen activator (u-PA) and its specific inhibitor, type 1 plasminogen activator inhibitor (PAI-1).	Tetradecanoylphorbol Acetate	0-3	transforming growth factor beta 1	Homo sapiens	125-135
2280608-4	1990	In the presence of a low (0.12 ng/ml) concentration of TPA, TNF-induced maturation was synergistically increased and Type I macrophages were formed.	Tetradecanoylphorbol Acetate	55-58	tumor necrosis factor	Homo sapiens	60-63
2197510-3	1990	TPA-treated K562 cells also synthesize and secrete platelet derived growth factor (PDGF), transforming growth factor beta 1 (TGF beta 1), urokinase-plasminogen activator (u-PA) and its specific inhibitor, type 1 plasminogen activator inhibitor (PAI-1).	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase	Homo sapiens	138-169
2280608-6	1990	As the TNF/TPA concentration increased, ML-1 cell differentiation was increasingly inhibited.	Tetradecanoylphorbol Acetate	11-14	tumor necrosis factor	Homo sapiens	7-10
2197510-3	1990	TPA-treated K562 cells also synthesize and secrete platelet derived growth factor (PDGF), transforming growth factor beta 1 (TGF beta 1), urokinase-plasminogen activator (u-PA) and its specific inhibitor, type 1 plasminogen activator inhibitor (PAI-1).	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase	Homo sapiens	171-175
2140592-0	1990	Inhibition of TPA-induced monocytic differentiation in THP-1 human monocytic leukemic cells by staurosporine, a potent protein kinase C inhibitor.	Tetradecanoylphorbol Acetate	14-17	GLI family zinc finger 2	Homo sapiens	55-60
2140592-1	1990	THP-1 is a factor-indepencent, monocytic leukemia cell line which differentiates into adherent macrophages upon treatment with 12-O-tetra-decanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	166-169	GLI family zinc finger 2	Homo sapiens	0-5
2140592-3	1990	Northern blot analysis showed that the c-FMS mRNA levels in THP-1 cells was greatly enhanced during TPA-induced monocytic differentiation.	Tetradecanoylphorbol Acetate	100-103	GLI family zinc finger 2	Homo sapiens	60-65
2167420-7	1990	In contrast, the protein kinase C activator, PMA, inhibited isoproterenol- and PGE1- (but not forskolin) induced cAMP accumulation.	Tetradecanoylphorbol Acetate	45-48	proline rich transmembrane protein 2	Homo sapiens	17-33
2140592-5	1990	The inducing activity associated with TPA was completely abrogated when THP-1 cells were pretreated with staurosporine, a potent protein kinase C (PK-C) inhibitor.	Tetradecanoylphorbol Acetate	38-41	GLI family zinc finger 2	Homo sapiens	72-77
2148811-1	1990	Phorbol ester (TPA)-induced down-regulation of the common ALL (CALLA) antigen was studied by continuous flow immunocytometry with the aid of several CD10 monoclonal antibodies, including a new CD10 monoclonal antibody (DGH-10-1-A9), shown to be of IgG1 isotype, recognizing a 100 kDa cell surface protein and effectively inhibited by a series of reference CD10 monoclonal antibodies.	Tetradecanoylphorbol Acetate	15-18	membrane metalloendopeptidase	Homo sapiens	63-68
2372371-6	1990	After a single topical application of 3.4 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse epidermis, total PKC activity in the cytosol fraction decreased rapidly to about 50% of control within 15 min and was accompanied by an increase (approximately 150% of control) of PKC activity in the membrane fraction.	Tetradecanoylphorbol Acetate	47-83	protein kinase C, alpha	Mus musculus	123-126
2372371-6	1990	After a single topical application of 3.4 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse epidermis, total PKC activity in the cytosol fraction decreased rapidly to about 50% of control within 15 min and was accompanied by an increase (approximately 150% of control) of PKC activity in the membrane fraction.	Tetradecanoylphorbol Acetate	47-83	protein kinase C, alpha	Mus musculus	286-289
2372371-6	1990	After a single topical application of 3.4 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse epidermis, total PKC activity in the cytosol fraction decreased rapidly to about 50% of control within 15 min and was accompanied by an increase (approximately 150% of control) of PKC activity in the membrane fraction.	Tetradecanoylphorbol Acetate	85-88	protein kinase C, alpha	Mus musculus	123-126
2372371-6	1990	After a single topical application of 3.4 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse epidermis, total PKC activity in the cytosol fraction decreased rapidly to about 50% of control within 15 min and was accompanied by an increase (approximately 150% of control) of PKC activity in the membrane fraction.	Tetradecanoylphorbol Acetate	85-88	protein kinase C, alpha	Mus musculus	286-289
2372371-7	1990	At 4 h, PKC activities were significantly lower than the control levels and remained downregulated through 96 h with a maximal decrease (to approximately 25-30% of the control) in both cytosol and membrane fractions at h. PKC activity returned to control levels by 168 h. Ca++/phospholipid-independent kinase activity was the same as control levels at 15 min, 1 h, and 4 h after TPA treatment but was elevated above control levels at 24 h, 48 h, and 96 h, and by 168 h returned essentially to control levels.	Tetradecanoylphorbol Acetate	379-382	protein kinase C, alpha	Mus musculus	8-11
2372371-7	1990	At 4 h, PKC activities were significantly lower than the control levels and remained downregulated through 96 h with a maximal decrease (to approximately 25-30% of the control) in both cytosol and membrane fractions at h. PKC activity returned to control levels by 168 h. Ca++/phospholipid-independent kinase activity was the same as control levels at 15 min, 1 h, and 4 h after TPA treatment but was elevated above control levels at 24 h, 48 h, and 96 h, and by 168 h returned essentially to control levels.	Tetradecanoylphorbol Acetate	379-382	protein kinase C, alpha	Mus musculus	222-225
2087244-3	1990	10(-6)-10(-7) M phorbol myristate acetate (PMA) but not phorbol didecanoate or 4-beta-phorbol activated CRC-/NL to lyse YAC-1 targets.	Tetradecanoylphorbol Acetate	16-41	ADP-ribosyltransferase 1	Mus musculus	120-125
2087244-3	1990	10(-6)-10(-7) M phorbol myristate acetate (PMA) but not phorbol didecanoate or 4-beta-phorbol activated CRC-/NL to lyse YAC-1 targets.	Tetradecanoylphorbol Acetate	43-46	ADP-ribosyltransferase 1	Mus musculus	120-125
2148811-1	1990	Phorbol ester (TPA)-induced down-regulation of the common ALL (CALLA) antigen was studied by continuous flow immunocytometry with the aid of several CD10 monoclonal antibodies, including a new CD10 monoclonal antibody (DGH-10-1-A9), shown to be of IgG1 isotype, recognizing a 100 kDa cell surface protein and effectively inhibited by a series of reference CD10 monoclonal antibodies.	Tetradecanoylphorbol Acetate	15-18	membrane metalloendopeptidase	Homo sapiens	149-153
2148811-1	1990	Phorbol ester (TPA)-induced down-regulation of the common ALL (CALLA) antigen was studied by continuous flow immunocytometry with the aid of several CD10 monoclonal antibodies, including a new CD10 monoclonal antibody (DGH-10-1-A9), shown to be of IgG1 isotype, recognizing a 100 kDa cell surface protein and effectively inhibited by a series of reference CD10 monoclonal antibodies.	Tetradecanoylphorbol Acetate	15-18	membrane metalloendopeptidase	Homo sapiens	193-197
2148811-1	1990	Phorbol ester (TPA)-induced down-regulation of the common ALL (CALLA) antigen was studied by continuous flow immunocytometry with the aid of several CD10 monoclonal antibodies, including a new CD10 monoclonal antibody (DGH-10-1-A9), shown to be of IgG1 isotype, recognizing a 100 kDa cell surface protein and effectively inhibited by a series of reference CD10 monoclonal antibodies.	Tetradecanoylphorbol Acetate	15-18	membrane metalloendopeptidase	Homo sapiens	193-197
2148811-2	1990	The TPA-induced down-regulation of CALLA on REH cells was demonstrated with the aid of the following CD10 monoclonal antibodies: J-5, VIL-A1 and DGH-10-1-A9.	Tetradecanoylphorbol Acetate	4-7	membrane metalloendopeptidase	Homo sapiens	35-40
2148811-2	1990	The TPA-induced down-regulation of CALLA on REH cells was demonstrated with the aid of the following CD10 monoclonal antibodies: J-5, VIL-A1 and DGH-10-1-A9.	Tetradecanoylphorbol Acetate	4-7	membrane metalloendopeptidase	Homo sapiens	101-105
2217443-11	1990	Among the megakaryocytic phenotypes, increase in GPIIb/IIIa complex, determined by a biochemical method, PPO by ultrastructural study, and the increase in cellular ploidy were clearly observed by PMA treatment.	Tetradecanoylphorbol Acetate	196-199	protoporphyrinogen oxidase	Homo sapiens	105-108
2196473-6	1990	Major induced alterations included down-regulation of CD4 (induced by TPA, and to a lesser extent by IFN-alpha), TPA-induced decrease of cell surface expression of transferrin receptor (unmodified by IFN-alpha) and IFN-alpha induced increase of antigen density (fluorescence intensity) of MHC class I antigen.	Tetradecanoylphorbol Acetate	113-116	transferrin	Homo sapiens	164-175
2196473-6	1990	Major induced alterations included down-regulation of CD4 (induced by TPA, and to a lesser extent by IFN-alpha), TPA-induced decrease of cell surface expression of transferrin receptor (unmodified by IFN-alpha) and IFN-alpha induced increase of antigen density (fluorescence intensity) of MHC class I antigen.	Tetradecanoylphorbol Acetate	113-116	interferon alpha 1	Homo sapiens	200-209
2196473-6	1990	Major induced alterations included down-regulation of CD4 (induced by TPA, and to a lesser extent by IFN-alpha), TPA-induced decrease of cell surface expression of transferrin receptor (unmodified by IFN-alpha) and IFN-alpha induced increase of antigen density (fluorescence intensity) of MHC class I antigen.	Tetradecanoylphorbol Acetate	113-116	interferon alpha 1	Homo sapiens	200-209
1701302-3	1990	Immunohistochemically, PMA-treated cells stained intensely for neuron-specific enolase and were positive for neurofilaments.	Tetradecanoylphorbol Acetate	23-26	enolase 2	Homo sapiens	63-86
2222808-2	1990	In combination with 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent activator of PKC, TNF-alpha caused marked growth inhibition of LoVo cells, but TNF-beta had little antiproliferative effect.	Tetradecanoylphorbol Acetate	20-56	tumor necrosis factor	Homo sapiens	91-100
2222808-2	1990	In combination with 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent activator of PKC, TNF-alpha caused marked growth inhibition of LoVo cells, but TNF-beta had little antiproliferative effect.	Tetradecanoylphorbol Acetate	58-61	tumor necrosis factor	Homo sapiens	91-100
2144421-4	1990	The protein kinase C (pKC) activity, unchanged in "control" and "TSH cells", was dramatically modified in TPA treated cells.	Tetradecanoylphorbol Acetate	106-109	PKC	Sus scrofa	4-20
2160083-2	1990	Calmodulin antagonists, chlorpromazine and trifluoperazine, inhibited free radical generation by human leukocytes in vitro induced by GLA, AA PMA (Phorbol myristate acetate), formyl-methionyl-leucyl-phenylalanine (FMLP) and lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	142-145	calmodulin 1	Homo sapiens	0-10
2160083-2	1990	Calmodulin antagonists, chlorpromazine and trifluoperazine, inhibited free radical generation by human leukocytes in vitro induced by GLA, AA PMA (Phorbol myristate acetate), formyl-methionyl-leucyl-phenylalanine (FMLP) and lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	147-172	calmodulin 1	Homo sapiens	0-10
2385549-4	1990	The phorbol ester TPA (12-O-tetradecanoyl-phorbol-13-acetate) induced the same effects as prolactin thereby indicating the involvement of protein kinase C. This report demonstrates that prolactin directly regulates citrate production of prostate epithelial cells and the availability of an in vitro model to elucidate the mechanism of action of prolactin.	Tetradecanoylphorbol Acetate	18-21	prolactin	Rattus norvegicus	186-195
2385549-4	1990	The phorbol ester TPA (12-O-tetradecanoyl-phorbol-13-acetate) induced the same effects as prolactin thereby indicating the involvement of protein kinase C. This report demonstrates that prolactin directly regulates citrate production of prostate epithelial cells and the availability of an in vitro model to elucidate the mechanism of action of prolactin.	Tetradecanoylphorbol Acetate	18-21	prolactin	Rattus norvegicus	186-195
2385549-4	1990	The phorbol ester TPA (12-O-tetradecanoyl-phorbol-13-acetate) induced the same effects as prolactin thereby indicating the involvement of protein kinase C. This report demonstrates that prolactin directly regulates citrate production of prostate epithelial cells and the availability of an in vitro model to elucidate the mechanism of action of prolactin.	Tetradecanoylphorbol Acetate	23-60	prolactin	Rattus norvegicus	186-195
2385549-4	1990	The phorbol ester TPA (12-O-tetradecanoyl-phorbol-13-acetate) induced the same effects as prolactin thereby indicating the involvement of protein kinase C. This report demonstrates that prolactin directly regulates citrate production of prostate epithelial cells and the availability of an in vitro model to elucidate the mechanism of action of prolactin.	Tetradecanoylphorbol Acetate	23-60	prolactin	Rattus norvegicus	186-195
2144421-4	1990	The protein kinase C (pKC) activity, unchanged in "control" and "TSH cells", was dramatically modified in TPA treated cells.	Tetradecanoylphorbol Acetate	106-109	PKC	Sus scrofa	22-25
2144421-10	1990	The modifications of pKC activity and LCI phosphorylation and the changes in the bio-signalling pathways can partly account for the loss of differentiation observed in control or TPA treated cells.	Tetradecanoylphorbol Acetate	179-182	PKC	Sus scrofa	21-24
2130511-18	1990	Activation of phospholipase D (PLD) was demonstrated by the finding that phosphatidic acid increased in response to PMA or carbachol prior to the increase in PA.	Tetradecanoylphorbol Acetate	116-119	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	14-29
2300789-5	1990	We also demonstrate that pretreatment of target cells with phorbol ester (PMA) decreases killing, suggesting that PKC activation in the target cell population may also influence killing although the effect may vary depending on the particular target cell used.	Tetradecanoylphorbol Acetate	74-77	proline rich transmembrane protein 2	Homo sapiens	114-117
2130511-18	1990	Activation of phospholipase D (PLD) was demonstrated by the finding that phosphatidic acid increased in response to PMA or carbachol prior to the increase in PA.	Tetradecanoylphorbol Acetate	116-119	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-34
1696041-3	1990	In this study the human myelomonoblast line THP-1 has been used to study monocytic differentiation in response to various cytokines and the phorbolester TPA.	Tetradecanoylphorbol Acetate	153-156	GLI family zinc finger 2	Homo sapiens	44-49
1696041-4	1990	After treatment of THP-1 cells with Tumor Necrosis Factor (TNF)-alpha, Interleukin (IL-6) and TPA the cells became adherent, lost their division potential and expressed new surface structures associated with monocytic differentiation.	Tetradecanoylphorbol Acetate	94-97	GLI family zinc finger 2	Homo sapiens	19-24
33237349-5	2021	Furthermore, the proliferation, migration, and tube formation of HUVECs were significantly inhibited by conditioned medium from a coculture system of the phorbol myristate acetate pretreated human THP-1 macrophages and let-7d-overexpressing RCC cells.	Tetradecanoylphorbol Acetate	154-179	microRNA let-7d	Homo sapiens	219-225
6808028-1	1982	In this study, we demonstrate that both highly purified T4+ and T8+ lymphocytes can produce substantial amounts of Interleukin 2(IL 2) when stimulated with the combination of concanavalin A (Con A) and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	202-227	interleukin 2	Homo sapiens	115-128
6808028-1	1982	In this study, we demonstrate that both highly purified T4+ and T8+ lymphocytes can produce substantial amounts of Interleukin 2(IL 2) when stimulated with the combination of concanavalin A (Con A) and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	202-227	interleukin 2	Homo sapiens	129-133
33971443-8	2021	Therefore, the molecule DBP-1 with a carbon-carbon double bond as the pi bridge has the largest transition dipole moments, TPA cross-section, and second static hyperpolarizability.	Tetradecanoylphorbol Acetate	123-126	DEAH-box helicase 15	Homo sapiens	24-29
33799840-2	2021	The aim of this study is to investigate the effects of hydrogen nano-bubble water (HW) on ROS generation, adipogenesis, and interleukin-6 (IL-6) secretion in hydrogen peroxide (H2O2) or phorbol 12-myristate 13-acetate (PMA)-stimulated OP9 adipocytes, and three-dimensional (3D) subcutaneous adipose equivalents.	Tetradecanoylphorbol Acetate	186-217	interleukin 6	Homo sapiens	139-143
33801658-7	2021	RESULTS: The two sphingosine-1-phosphate receptors (S1PRs) expressed in peritoneal B cell subsets S1P1 and S1P4 are differentially regulated upon stimulation with the TLR4 agonist LPS, but not upon PMA/ionomycin or B cell receptor (BCR) crosslinking.	Tetradecanoylphorbol Acetate	198-201	sphingosine-1-phosphate receptor 4	Homo sapiens	107-111
33799840-0	2021	Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents.	Tetradecanoylphorbol Acetate	121-124	interleukin 6	Homo sapiens	72-85
33034831-6	2021	After stimulation with phorbol myristate acetate/ionomycin, the Akt1 and phosphorylated-Akt1 (p-Akt1) levels of T cell subsets were detected with intracellular staining using flow cytometry.	Tetradecanoylphorbol Acetate	23-48	AKT serine/threonine kinase 1	Homo sapiens	64-68
33237422-8	2021	PMA induced the MAPK pathway in HeLa cells through the activation of ERK, CREB, and RSK1.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	69-72
33034831-6	2021	After stimulation with phorbol myristate acetate/ionomycin, the Akt1 and phosphorylated-Akt1 (p-Akt1) levels of T cell subsets were detected with intracellular staining using flow cytometry.	Tetradecanoylphorbol Acetate	23-48	AKT serine/threonine kinase 1	Homo sapiens	88-92
33034831-6	2021	After stimulation with phorbol myristate acetate/ionomycin, the Akt1 and phosphorylated-Akt1 (p-Akt1) levels of T cell subsets were detected with intracellular staining using flow cytometry.	Tetradecanoylphorbol Acetate	23-48	AKT serine/threonine kinase 1	Homo sapiens	88-92
23614738-10	2013	TNFalpha, 12-O-Tetradecanoylphorbol 13-acetate (TPA) and UVB irradiation induced Ser727 phosphorylation of STAT3 in an ERK1/2- and p38 MAPK-dependent manner, which resulted in a modulatory effect on STAT3 transcriptional activity.	Tetradecanoylphorbol Acetate	10-46	signal transducer and activator of transcription 3	Homo sapiens	107-112
32140039-0	2020	Eupatilin downregulates phorbol 12-myristate 13-acetate-induced MUC5AC expression via inhibition of p38/ERK/JNK MAPKs signal pathway in human airway epithelial cells.	Tetradecanoylphorbol Acetate	24-55	mitogen-activated protein kinase 14	Homo sapiens	100-103
32140039-0	2020	Eupatilin downregulates phorbol 12-myristate 13-acetate-induced MUC5AC expression via inhibition of p38/ERK/JNK MAPKs signal pathway in human airway epithelial cells.	Tetradecanoylphorbol Acetate	24-55	mitogen-activated protein kinase 1	Homo sapiens	104-107
32140039-0	2020	Eupatilin downregulates phorbol 12-myristate 13-acetate-induced MUC5AC expression via inhibition of p38/ERK/JNK MAPKs signal pathway in human airway epithelial cells.	Tetradecanoylphorbol Acetate	24-55	mitogen-activated protein kinase 8	Homo sapiens	108-111
28915606-10	2017	Matriptase silencing in the Her2, matriptase, and HAI-1 triple-positive SKBR3 human breast cancer cells enhanced Her2 protein down-regulation induced by a sustained exposure to phorbol 12-myristate 13-acetate (PMA), which down-regulated matriptase protein.	Tetradecanoylphorbol Acetate	177-208	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-32
28915606-10	2017	Matriptase silencing in the Her2, matriptase, and HAI-1 triple-positive SKBR3 human breast cancer cells enhanced Her2 protein down-regulation induced by a sustained exposure to phorbol 12-myristate 13-acetate (PMA), which down-regulated matriptase protein.	Tetradecanoylphorbol Acetate	177-208	erb-b2 receptor tyrosine kinase 2	Homo sapiens	113-117
23614738-10	2013	TNFalpha, 12-O-Tetradecanoylphorbol 13-acetate (TPA) and UVB irradiation induced Ser727 phosphorylation of STAT3 in an ERK1/2- and p38 MAPK-dependent manner, which resulted in a modulatory effect on STAT3 transcriptional activity.	Tetradecanoylphorbol Acetate	10-46	mitogen-activated protein kinase 3	Homo sapiens	119-125
23614738-10	2013	TNFalpha, 12-O-Tetradecanoylphorbol 13-acetate (TPA) and UVB irradiation induced Ser727 phosphorylation of STAT3 in an ERK1/2- and p38 MAPK-dependent manner, which resulted in a modulatory effect on STAT3 transcriptional activity.	Tetradecanoylphorbol Acetate	10-46	signal transducer and activator of transcription 3	Homo sapiens	199-204
23614738-10	2013	TNFalpha, 12-O-Tetradecanoylphorbol 13-acetate (TPA) and UVB irradiation induced Ser727 phosphorylation of STAT3 in an ERK1/2- and p38 MAPK-dependent manner, which resulted in a modulatory effect on STAT3 transcriptional activity.	Tetradecanoylphorbol Acetate	48-51	tumor necrosis factor	Homo sapiens	0-8
23614738-10	2013	TNFalpha, 12-O-Tetradecanoylphorbol 13-acetate (TPA) and UVB irradiation induced Ser727 phosphorylation of STAT3 in an ERK1/2- and p38 MAPK-dependent manner, which resulted in a modulatory effect on STAT3 transcriptional activity.	Tetradecanoylphorbol Acetate	48-51	signal transducer and activator of transcription 3	Homo sapiens	107-112
23614738-10	2013	TNFalpha, 12-O-Tetradecanoylphorbol 13-acetate (TPA) and UVB irradiation induced Ser727 phosphorylation of STAT3 in an ERK1/2- and p38 MAPK-dependent manner, which resulted in a modulatory effect on STAT3 transcriptional activity.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 3	Homo sapiens	119-125
23614738-10	2013	TNFalpha, 12-O-Tetradecanoylphorbol 13-acetate (TPA) and UVB irradiation induced Ser727 phosphorylation of STAT3 in an ERK1/2- and p38 MAPK-dependent manner, which resulted in a modulatory effect on STAT3 transcriptional activity.	Tetradecanoylphorbol Acetate	48-51	signal transducer and activator of transcription 3	Homo sapiens	199-204
10097788-8	1999	RESULTS: Phorbol-myristate-acetate and ionomycine strongly increase the percent-age of IL-2+ cells; an additional 50% HCSs significantly suppresses the percentage to, or below the level of unstimulated cells.	Tetradecanoylphorbol Acetate	9-34	interleukin 2	Homo sapiens	87-91
21454541-4	2011	Interestingly, silencing p23 from LNCaP prostate cancer cells using RNAi markedly enhanced PKCdelta-dependent apoptosis and activation of PKCdelta downstream effectors ROCK and JNK by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	184-215	mitogen-activated protein kinase 8	Homo sapiens	177-180
12446683-5	2003	This PMA induction was blocked with the MEK inhibitor UO126, suggesting that the PMA-induced activation of the hTFPI-2 promoter is mediated through MEK.	Tetradecanoylphorbol Acetate	5-8	mitogen-activated protein kinase kinase 7	Homo sapiens	40-43
12446683-5	2003	This PMA induction was blocked with the MEK inhibitor UO126, suggesting that the PMA-induced activation of the hTFPI-2 promoter is mediated through MEK.	Tetradecanoylphorbol Acetate	5-8	tissue factor pathway inhibitor 2	Homo sapiens	111-118
12446683-5	2003	This PMA induction was blocked with the MEK inhibitor UO126, suggesting that the PMA-induced activation of the hTFPI-2 promoter is mediated through MEK.	Tetradecanoylphorbol Acetate	5-8	mitogen-activated protein kinase kinase 7	Homo sapiens	148-151
11222479-3	2001	This study investigates the effect of interferon (IFN)-gamma on VLDL receptor expression in phorbol-12-myristate-13-acetate (PMA)-treated THP-1, HL-60 macrophages, and human monocyte-derived macrophages.	Tetradecanoylphorbol Acetate	92-123	interferon gamma	Homo sapiens	38-60
11222479-3	2001	This study investigates the effect of interferon (IFN)-gamma on VLDL receptor expression in phorbol-12-myristate-13-acetate (PMA)-treated THP-1, HL-60 macrophages, and human monocyte-derived macrophages.	Tetradecanoylphorbol Acetate	92-123	GLI family zinc finger 2	Homo sapiens	138-143
11222479-3	2001	This study investigates the effect of interferon (IFN)-gamma on VLDL receptor expression in phorbol-12-myristate-13-acetate (PMA)-treated THP-1, HL-60 macrophages, and human monocyte-derived macrophages.	Tetradecanoylphorbol Acetate	125-128	interferon gamma	Homo sapiens	38-60
11222479-3	2001	This study investigates the effect of interferon (IFN)-gamma on VLDL receptor expression in phorbol-12-myristate-13-acetate (PMA)-treated THP-1, HL-60 macrophages, and human monocyte-derived macrophages.	Tetradecanoylphorbol Acetate	125-128	GLI family zinc finger 2	Homo sapiens	138-143
11222479-7	2001	In THP-1 macrophages, VLDL receptor protein expression decreased at 2 days after PMA treatment but increased at 3 days and increased up to 5 days.	Tetradecanoylphorbol Acetate	81-84	GLI family zinc finger 2	Homo sapiens	3-8
10514480-8	1999	Fluorescent PTH antagonist-hPTH1-Rc complexes were rapidly internalized after PKC activation by phorbol 12-myristate 13-acetate or thrombin, but not after stimulation of the cAMP/protein kinase A pathway by forskolin.	Tetradecanoylphorbol Acetate	96-127	parathyroid hormone	Homo sapiens	12-15
8570188-4	1995	Transient transfection of MAPK phosphatase-1 (MKP-1), a protein phosphatase which preferentially dephosphorylates and inactivates MAPK, inhibited the functional effects of both PMA and the constitutively active MEK1 mutants.	Tetradecanoylphorbol Acetate	177-180	dual specificity phosphatase 1	Homo sapiens	26-44
8070364-4	1994	PLD was also activated by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	26-62	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
8570188-4	1995	Transient transfection of MAPK phosphatase-1 (MKP-1), a protein phosphatase which preferentially dephosphorylates and inactivates MAPK, inhibited the functional effects of both PMA and the constitutively active MEK1 mutants.	Tetradecanoylphorbol Acetate	177-180	dual specificity phosphatase 1	Homo sapiens	46-51
7479387-2	1995	The treatment of cells with the PKC activator phorbol 12-myristate 13-acetate (PMA) resulted in an impairment of the stimulation of adenylyl cyclase activity in terms of both potency, as seen with both vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase-activating peptide (PACAP-27), and efficacy, as seen with the beta-adrenergic agonist isoproterenol.	Tetradecanoylphorbol Acetate	46-77	vasoactive intestinal peptide	Rattus norvegicus	233-236
7479387-2	1995	The treatment of cells with the PKC activator phorbol 12-myristate 13-acetate (PMA) resulted in an impairment of the stimulation of adenylyl cyclase activity in terms of both potency, as seen with both vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase-activating peptide (PACAP-27), and efficacy, as seen with the beta-adrenergic agonist isoproterenol.	Tetradecanoylphorbol Acetate	79-82	vasoactive intestinal peptide	Rattus norvegicus	233-236
7843129-8	1994	Whereas unstimulated cells produced 0.4 pmole paf/2 x 10(6) cells, the stimulation with low fMLP (0.1 microM) resulted in the synthesis of 1.7 pmole and with low TPA (2 ng/ml) in 0.5 pmole paf.	Tetradecanoylphorbol Acetate	162-165	formyl peptide receptor 1	Homo sapiens	92-96
9048771-3	1997	The PKC activator phorbol 12-myristate 13-acetate (PMA) decreased glutamate transport activity in Xenopus oocytes and human embryonic kidney cells (HEK293) expressing the cloned GLAST-1 cDNA, within 20 min, to 25% of the initial transport activity.	Tetradecanoylphorbol Acetate	18-49	solute carrier family 1 member 3	Homo sapiens	178-185
9048771-3	1997	The PKC activator phorbol 12-myristate 13-acetate (PMA) decreased glutamate transport activity in Xenopus oocytes and human embryonic kidney cells (HEK293) expressing the cloned GLAST-1 cDNA, within 20 min, to 25% of the initial transport activity.	Tetradecanoylphorbol Acetate	51-54	solute carrier family 1 member 3	Homo sapiens	178-185
7669726-2	1995	We studied the effect and the mechanism of action of phorbol ester (TPA) on the expression of ctsl mRNA in U937 histiocytic leukemia cells.	Tetradecanoylphorbol Acetate	68-71	cathepsin L	Homo sapiens	94-98
7669726-3	1995	TPA treatment induces ctsl mRNA in a manner that is dose-dependent, occurs at the level of transcription, and is ablated by cotreatment with cycloheximide but is unaffected by dexamethasone.	Tetradecanoylphorbol Acetate	0-3	cathepsin L	Homo sapiens	22-26
7669726-4	1995	Treatment with TPA plus staurosporine, a potent protein kinase C inhibitor, results in greater expression of ctsl mRNA than does treatment with TPA alone.	Tetradecanoylphorbol Acetate	15-18	cathepsin L	Homo sapiens	109-113
7669726-4	1995	Treatment with TPA plus staurosporine, a potent protein kinase C inhibitor, results in greater expression of ctsl mRNA than does treatment with TPA alone.	Tetradecanoylphorbol Acetate	144-147	cathepsin L	Homo sapiens	109-113
7669726-8	1995	In contrast, the tyrosine kinase inhibitors herbimycin A and genistein inhibit the effect of TPA and staurosporine upon ctsl mRNA with little or no effect on c-jun expression.	Tetradecanoylphorbol Acetate	93-96	cathepsin L	Homo sapiens	120-124
7669726-9	1995	Pretreatment with sodium orthovanadate enhances the induction of ctsl expression by TPA and staurosporine.	Tetradecanoylphorbol Acetate	84-87	cathepsin L	Homo sapiens	65-69
7669726-10	1995	These data suggest that, in U937 cells, TPA-stimulated ctsl gene transcription is apparently activated by a protein kinase C-independent signal transduction pathway involving tyrosine kinase activation.	Tetradecanoylphorbol Acetate	40-43	cathepsin L	Homo sapiens	55-59
8070351-4	1994	In VSMC, angiotensin-II, which induces PTHrP expression, also rapidly (30 min) desensitized the cAMP response and down-regulated (75-90%) receptor mRNA within 1 h. Treatment of cells with phorbol 12-myristate 13-acetate (0.1 microM) mimicked these effects, whereas neither PTHrP-(1-34)NH2, forskolin, nor (Bu)2cAMP altered receptor mRNA expression.	Tetradecanoylphorbol Acetate	188-219	angiotensinogen	Rattus norvegicus	9-23
7880978-7	1994	IL-2 and IFN-gamma mRNA were detectable in PBMC as early as 3 hours after in vitro stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	100-103	interleukin 2	Homo sapiens	0-4
8070364-4	1994	PLD was also activated by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	64-67	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
7880978-7	1994	IL-2 and IFN-gamma mRNA were detectable in PBMC as early as 3 hours after in vitro stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	100-103	interferon gamma	Homo sapiens	9-18
34968577-13	2022	Treatment of HK-2 cells with ERK-specific inhibitor SCH772984 and agonist TPA validated LMCD1 exerted its function via activating ERK signaling.	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 1	Mus musculus	29-32
34847489-0	2022	Acute Hyperglycemia Exacerbates Hemorrhagic Transformation after Embolic Stroke and Reperfusion with tPA: A Possible Role of TXNIP-NLRP3 Inflammasome.	Tetradecanoylphorbol Acetate	101-104	thioredoxin interacting protein	Mus musculus	125-130
34890758-6	2022	In MH-S alveolar macrophages, PMA-induced pro-inflammatory responses, including iNOS, COX-2, MMP-9 and cytokines expressions were reduced by cardamonin.	Tetradecanoylphorbol Acetate	30-33	nitric oxide synthase 2, inducible	Mus musculus	80-84
34968577-13	2022	Treatment of HK-2 cells with ERK-specific inhibitor SCH772984 and agonist TPA validated LMCD1 exerted its function via activating ERK signaling.	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 1	Mus musculus	130-133
34886783-0	2021	The Effects of Stimulation with PMA/Ionomycin on CD4+ T cell Proliferation and Surface CD4 Molecule Modulation of Patients with LRBA Deficiency and CVID with the Unsolved Genetic Defect.	Tetradecanoylphorbol Acetate	32-35	CD4 molecule	Homo sapiens	49-52
34903321-6	2022	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) changed the expression levels of EMT markers, increasing alpha-SMA, vimentin, and MMP-9 expression and decreasing E-cadherin expression, with changes in cell morphology.	Tetradecanoylphorbol Acetate	15-51	actin alpha 1, skeletal muscle	Homo sapiens	115-124
34903321-6	2022	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) changed the expression levels of EMT markers, increasing alpha-SMA, vimentin, and MMP-9 expression and decreasing E-cadherin expression, with changes in cell morphology.	Tetradecanoylphorbol Acetate	15-51	cadherin 1	Homo sapiens	172-182
34903321-6	2022	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) changed the expression levels of EMT markers, increasing alpha-SMA, vimentin, and MMP-9 expression and decreasing E-cadherin expression, with changes in cell morphology.	Tetradecanoylphorbol Acetate	53-56	actin alpha 1, skeletal muscle	Homo sapiens	115-124
34903321-6	2022	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) changed the expression levels of EMT markers, increasing alpha-SMA, vimentin, and MMP-9 expression and decreasing E-cadherin expression, with changes in cell morphology.	Tetradecanoylphorbol Acetate	53-56	cadherin 1	Homo sapiens	172-182
34903321-9	2022	Inhibition of aurora kinase A blocked TPA-induced vimentin and MMP-9 expression, and decreased E-cadherin expression.	Tetradecanoylphorbol Acetate	38-41	cadherin 1	Homo sapiens	95-105
34884902-2	2021	We recently reported that the small molecule inhibitors, TPCA-1 and IKK-16, which target nuclear factor kappaB (NF-kappaB) activation, moderately reduced Eomes-dependent IFN-gamma expression in mouse lymphoma BW5147 cells stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	238-269	interferon gamma	Mus musculus	170-179
34884902-2	2021	We recently reported that the small molecule inhibitors, TPCA-1 and IKK-16, which target nuclear factor kappaB (NF-kappaB) activation, moderately reduced Eomes-dependent IFN-gamma expression in mouse lymphoma BW5147 cells stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	271-274	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	112-121
34884902-2	2021	We recently reported that the small molecule inhibitors, TPCA-1 and IKK-16, which target nuclear factor kappaB (NF-kappaB) activation, moderately reduced Eomes-dependent IFN-gamma expression in mouse lymphoma BW5147 cells stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	271-274	interferon gamma	Mus musculus	170-179
34884902-7	2021	In effector CD4+ and CD8+ T cells activated with anti-CD3 and anti-CD28 antibodies, IFN-gamma expression induced by PMA and A23187 was not markedly decreased by TPCA-1 or IKK-16 under conditions where IL-2 expression was markedly reduced.	Tetradecanoylphorbol Acetate	116-119	interferon gamma	Mus musculus	84-93
34859377-5	2021	An inhibition model of sh-Nrf2 was constructed via a lentivirus expression system, and an activation model of NF-kappaB was achieved using phorbol 12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	139-170	NFE2 like bZIP transcription factor 2	Rattus norvegicus	26-30
34859377-5	2021	An inhibition model of sh-Nrf2 was constructed via a lentivirus expression system, and an activation model of NF-kappaB was achieved using phorbol 12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	172-175	NFE2 like bZIP transcription factor 2	Rattus norvegicus	26-30
33535882-6	2021	Further evidence showed that PKCepsilon knockdown by siRNA antagonized the AngII-induced chronic inhibition on the I Ks current, whereas knockdown of cPKC (PKCalpha and PKCbeta) attenuated the inhibition effect of PMA on the current.	Tetradecanoylphorbol Acetate	214-217	protein kinase C alpha	Homo sapiens	156-164
34547515-6	2021	Our study showed that isolation of T cells with the EasySep procedure, followed by activation with PMA/ionomycin, mimicked the psoriatic characteristics in an optimal manner with the production of inflammatory cytokines important in the pathogenesis of psoriasis, as well as increased expression of Ki67, S100A7, elafin and involucrin.	Tetradecanoylphorbol Acetate	99-102	S100 calcium binding protein A7	Homo sapiens	305-311
34547515-6	2021	Our study showed that isolation of T cells with the EasySep procedure, followed by activation with PMA/ionomycin, mimicked the psoriatic characteristics in an optimal manner with the production of inflammatory cytokines important in the pathogenesis of psoriasis, as well as increased expression of Ki67, S100A7, elafin and involucrin.	Tetradecanoylphorbol Acetate	99-102	involucrin	Homo sapiens	324-334
34592416-5	2021	The PMA-treated S1P2knockout THP-1 Mphis showed decreases in IL-4/IL-13-induced phosphorylation of Janus-activated kinase (JAK) 1, JAK2, and STAT6 as well as mRNA expression of the M2 marker ARG1 compared with wild-type THP-1 Mphis.	Tetradecanoylphorbol Acetate	4-7	interleukin 4	Homo sapiens	61-65
34592416-5	2021	The PMA-treated S1P2knockout THP-1 Mphis showed decreases in IL-4/IL-13-induced phosphorylation of Janus-activated kinase (JAK) 1, JAK2, and STAT6 as well as mRNA expression of the M2 marker ARG1 compared with wild-type THP-1 Mphis.	Tetradecanoylphorbol Acetate	4-7	interleukin 13	Homo sapiens	66-71
34592416-5	2021	The PMA-treated S1P2knockout THP-1 Mphis showed decreases in IL-4/IL-13-induced phosphorylation of Janus-activated kinase (JAK) 1, JAK2, and STAT6 as well as mRNA expression of the M2 marker ARG1 compared with wild-type THP-1 Mphis.	Tetradecanoylphorbol Acetate	4-7	Janus kinase 1	Homo sapiens	99-129
34592416-6	2021	Pretreatment of PMA-treated THP-1 Mphis with the S1P2 antagonist JTE-013, the Rho inhibitor Rhosin or the Rho kinase inhibitor Y27632 inhibited the IL-4/IL-13-induced increase in STAT6 phosphorylation.	Tetradecanoylphorbol Acetate	16-19	interleukin 4	Homo sapiens	148-152
34592416-6	2021	Pretreatment of PMA-treated THP-1 Mphis with the S1P2 antagonist JTE-013, the Rho inhibitor Rhosin or the Rho kinase inhibitor Y27632 inhibited the IL-4/IL-13-induced increase in STAT6 phosphorylation.	Tetradecanoylphorbol Acetate	16-19	interleukin 13	Homo sapiens	153-158
33535882-6	2021	Further evidence showed that PKCepsilon knockdown by siRNA antagonized the AngII-induced chronic inhibition on the I Ks current, whereas knockdown of cPKC (PKCalpha and PKCbeta) attenuated the inhibition effect of PMA on the current.	Tetradecanoylphorbol Acetate	214-217	protein kinase C alpha	Homo sapiens	169-176
34608498-8	2021	Furthermore, downregulation of matriptase suppressed TPA-induced MMP-9 expression and invasiveness via PAR-2/PLCgamma2/PKC/MAPK activation.	Tetradecanoylphorbol Acetate	53-56	proline rich transmembrane protein 2	Homo sapiens	119-122
34867961-9	2021	In stimulating peripheral blood mononuclear cells using PMA plus ionomycin, a high TIM3 level on T cells correlated with low interleukin-2 and tumor necrosis factor-alpha (TNF-alpha) on CD4+ cells and interferon-gamma and TNF-alpha on CD8+ T cells.	Tetradecanoylphorbol Acetate	56-59	interleukin 2	Homo sapiens	125-138
34689117-6	2021	Furthermore, the level of cytokine production was measured in the Jurkat T cell line stimulated with phorbol 12-myristate 13-acetate/ionomycin and bavachin using an IL-2 ELISA and a cytometric bead array assay.	Tetradecanoylphorbol Acetate	101-132	interleukin 2	Homo sapiens	165-169
34808221-10	2021	T-Mig was found to be associated with iv-tPA administration prior to thrombectomy (beta-estimate 2.52; 95% CI (1.25-3.79); p<0.001), fewer device passes during thrombectomy (1.22+-1.31 vs 1.66+-0.99; p<0.05), and shorter pre-treatment thrombi (beta-estimate -0.1millimeter; 95% CI (-0.27-0.07); p<0.05).	Tetradecanoylphorbol Acetate	41-44	C-X-C motif chemokine ligand 9	Homo sapiens	2-5
34867961-9	2021	In stimulating peripheral blood mononuclear cells using PMA plus ionomycin, a high TIM3 level on T cells correlated with low interleukin-2 and tumor necrosis factor-alpha (TNF-alpha) on CD4+ cells and interferon-gamma and TNF-alpha on CD8+ T cells.	Tetradecanoylphorbol Acetate	56-59	tumor necrosis factor	Homo sapiens	143-170
34867961-9	2021	In stimulating peripheral blood mononuclear cells using PMA plus ionomycin, a high TIM3 level on T cells correlated with low interleukin-2 and tumor necrosis factor-alpha (TNF-alpha) on CD4+ cells and interferon-gamma and TNF-alpha on CD8+ T cells.	Tetradecanoylphorbol Acetate	56-59	tumor necrosis factor	Homo sapiens	172-181
34867961-9	2021	In stimulating peripheral blood mononuclear cells using PMA plus ionomycin, a high TIM3 level on T cells correlated with low interleukin-2 and tumor necrosis factor-alpha (TNF-alpha) on CD4+ cells and interferon-gamma and TNF-alpha on CD8+ T cells.	Tetradecanoylphorbol Acetate	56-59	CD4 molecule	Homo sapiens	186-189
34867961-9	2021	In stimulating peripheral blood mononuclear cells using PMA plus ionomycin, a high TIM3 level on T cells correlated with low interleukin-2 and tumor necrosis factor-alpha (TNF-alpha) on CD4+ cells and interferon-gamma and TNF-alpha on CD8+ T cells.	Tetradecanoylphorbol Acetate	56-59	interferon gamma	Homo sapiens	201-217
34867961-9	2021	In stimulating peripheral blood mononuclear cells using PMA plus ionomycin, a high TIM3 level on T cells correlated with low interleukin-2 and tumor necrosis factor-alpha (TNF-alpha) on CD4+ cells and interferon-gamma and TNF-alpha on CD8+ T cells.	Tetradecanoylphorbol Acetate	56-59	tumor necrosis factor	Homo sapiens	222-231
34565719-2	2021	The cells were pretreated with eriodictyol for 30 min and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 h. The effect of eriodictyol on PMA-induced nuclear factor kappa B (NF-kappaB) signaling pathway was also investigated.	Tetradecanoylphorbol Acetate	156-159	nuclear factor kappa B subunit 1	Homo sapiens	168-190
34804038-7	2021	However, EBV exposure impaired the cytokine (IFN-gamma, IL-2, and TNF-alpha) secretion capability of CD4+ and CD8+ T cells after stimulation with PMA/ionomycin in vitro.	Tetradecanoylphorbol Acetate	146-149	interferon gamma	Homo sapiens	45-54
34804038-7	2021	However, EBV exposure impaired the cytokine (IFN-gamma, IL-2, and TNF-alpha) secretion capability of CD4+ and CD8+ T cells after stimulation with PMA/ionomycin in vitro.	Tetradecanoylphorbol Acetate	146-149	interleukin 2	Homo sapiens	56-60
34804038-7	2021	However, EBV exposure impaired the cytokine (IFN-gamma, IL-2, and TNF-alpha) secretion capability of CD4+ and CD8+ T cells after stimulation with PMA/ionomycin in vitro.	Tetradecanoylphorbol Acetate	146-149	tumor necrosis factor	Homo sapiens	66-75
34804038-7	2021	However, EBV exposure impaired the cytokine (IFN-gamma, IL-2, and TNF-alpha) secretion capability of CD4+ and CD8+ T cells after stimulation with PMA/ionomycin in vitro.	Tetradecanoylphorbol Acetate	146-149	CD4 molecule	Homo sapiens	101-104
34751824-8	2022	Adam17 knockout decreased matrix metallopeptidase 13 (Mmp13) expression in both in vivo and in vitro experiments, whereas Adam17 activation by phorbol-12-myristate-13-acetate (PMA) increased Mmp13 and decreased aggrecan in mouse primary chondrocytes.	Tetradecanoylphorbol Acetate	143-174	a disintegrin and metallopeptidase domain 17	Mus musculus	122-128
34751824-8	2022	Adam17 knockout decreased matrix metallopeptidase 13 (Mmp13) expression in both in vivo and in vitro experiments, whereas Adam17 activation by phorbol-12-myristate-13-acetate (PMA) increased Mmp13 and decreased aggrecan in mouse primary chondrocytes.	Tetradecanoylphorbol Acetate	176-179	a disintegrin and metallopeptidase domain 17	Mus musculus	122-128
34565719-2	2021	The cells were pretreated with eriodictyol for 30 min and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 h. The effect of eriodictyol on PMA-induced nuclear factor kappa B (NF-kappaB) signaling pathway was also investigated.	Tetradecanoylphorbol Acetate	156-159	nuclear factor kappa B subunit 1	Homo sapiens	192-201
34312810-5	2021	Phorbol 12-myristate 13-acetate and staurosporine, which induced cell adhesion to fibronectin surface and ERM dephosphorylation, caused a decrease in surface stiffness in KG-1 cells.	Tetradecanoylphorbol Acetate	0-31	fibronectin 1	Homo sapiens	82-93
34724217-3	2022	Interestingly, 50 mmHg mechanical stressing induced the nuclear localization of NFAT1; but conversely decreased C-Jun and inhibited the expression of CD69 in lymphocytes under lipopolysaccharide or phorbol 12-myristate 13-acetate/ionomycin stimulation.	Tetradecanoylphorbol Acetate	198-229	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2	Mus musculus	80-85
34732304-12	2021	The inflammatory cytokines, TNF-alpha and IL-6, were significantly increased after HDAC6 knockdown in PMA-stimulated THP1 cells and SW982 cells (p < 0.05).	Tetradecanoylphorbol Acetate	102-105	tumor necrosis factor	Homo sapiens	28-37
34436652-8	2021	In HT29 cells, phorbol 12-myristate 13-acetate (PMA) induced COX-2 expression and increased CD44 and ICAM-1 levels were down-regulated by diclofenac.	Tetradecanoylphorbol Acetate	15-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	61-66
34436652-8	2021	In HT29 cells, phorbol 12-myristate 13-acetate (PMA) induced COX-2 expression and increased CD44 and ICAM-1 levels were down-regulated by diclofenac.	Tetradecanoylphorbol Acetate	48-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	61-66
34436652-10	2021	Treatment with both diclofenac and PMA significantly increased the number of apoptotic cells and caspase-3 activity in colon adenocarcinoma cells compared to control groups.	Tetradecanoylphorbol Acetate	35-38	caspase 3	Homo sapiens	97-106
34536821-8	2021	Phorbol 12-myristate 13-acetate (PMA) and lipopolysaccharide (LPS), the agonists of PKC and NF-kappaB signaling, respectively, significantly inhibit hp65-mediated UGT1A1 luciferase activity.	Tetradecanoylphorbol Acetate	0-31	nuclear factor kappa B subunit 1	Homo sapiens	92-101
34536821-8	2021	Phorbol 12-myristate 13-acetate (PMA) and lipopolysaccharide (LPS), the agonists of PKC and NF-kappaB signaling, respectively, significantly inhibit hp65-mediated UGT1A1 luciferase activity.	Tetradecanoylphorbol Acetate	33-36	nuclear factor kappa B subunit 1	Homo sapiens	92-101
34732304-12	2021	The inflammatory cytokines, TNF-alpha and IL-6, were significantly increased after HDAC6 knockdown in PMA-stimulated THP1 cells and SW982 cells (p < 0.05).	Tetradecanoylphorbol Acetate	102-105	interleukin 6	Homo sapiens	42-46
34732304-12	2021	The inflammatory cytokines, TNF-alpha and IL-6, were significantly increased after HDAC6 knockdown in PMA-stimulated THP1 cells and SW982 cells (p < 0.05).	Tetradecanoylphorbol Acetate	102-105	histone deacetylase 6	Homo sapiens	83-88
34768934-7	2021	Incubation of melanoma cells with phorbol ester (PMA) increased PKC-1beta level and hyperphosphorylation of RIPK4 resulting in degradation of RIPK4.	Tetradecanoylphorbol Acetate	49-52	receptor interacting serine/threonine kinase 4	Homo sapiens	108-113
34697988-0	2021	EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 3	Homo sapiens	73-79
34697988-10	2021	This study evidenced a positive role of EloA in HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity.	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 3	Homo sapiens	107-113
34768934-7	2021	Incubation of melanoma cells with phorbol ester (PMA) increased PKC-1beta level and hyperphosphorylation of RIPK4 resulting in degradation of RIPK4.	Tetradecanoylphorbol Acetate	49-52	receptor interacting serine/threonine kinase 4	Homo sapiens	142-147
34437989-11	2021	These data suggest that PMA treatment induces IL1beta and TNF-alpha release and modulation of TNFRI/TNFRII expression promoting RGCs survival after axotomy.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 alpha	Rattus norvegicus	46-53
34437989-11	2021	These data suggest that PMA treatment induces IL1beta and TNF-alpha release and modulation of TNFRI/TNFRII expression promoting RGCs survival after axotomy.	Tetradecanoylphorbol Acetate	24-27	tumor necrosis factor	Rattus norvegicus	58-67
34437989-0	2021	PMA treatment fosters rat retinal ganglion cell survival via TNF signaling.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Rattus norvegicus	61-64
34437989-4	2021	We hypothesize that the increase in RGCs survival mediated by PMA treatment depends upon modulation of the levels of IL-1beta and TNF-alpha.	Tetradecanoylphorbol Acetate	62-65	interleukin 1 alpha	Rattus norvegicus	117-125
34437989-4	2021	We hypothesize that the increase in RGCs survival mediated by PMA treatment depends upon modulation of the levels of IL-1beta and TNF-alpha.	Tetradecanoylphorbol Acetate	62-65	tumor necrosis factor	Rattus norvegicus	130-139
34369554-9	2021	On the other hand, AGFG2 downregulation resulted in the inhibition of vWF secretion upon Phorbol 12-myristate 13-acetate (PMA) or histamine stimulation, suggesting that AGFG2 plays a role in vWF exocytosis.	Tetradecanoylphorbol Acetate	89-120	von Willebrand factor	Homo sapiens	70-73
34437989-5	2021	The effect of PMA treatment was assayed on cell viability, caspase 3 activation, TNF-alpha and IL-1beta release and TNF receptor type I (TNFRI) and TNF receptor type II (TNFRII) levels.	Tetradecanoylphorbol Acetate	14-17	tumor necrosis factor	Rattus norvegicus	81-90
34437989-5	2021	The effect of PMA treatment was assayed on cell viability, caspase 3 activation, TNF-alpha and IL-1beta release and TNF receptor type I (TNFRI) and TNF receptor type II (TNFRII) levels.	Tetradecanoylphorbol Acetate	14-17	interleukin 1 alpha	Rattus norvegicus	95-103
34437989-6	2021	PMA treatment increases IL-1beta and TNF-alpha levels in 15 minutes in culture and increases the release of both cytokines after 30 minutes and 24h, respectively.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 alpha	Rattus norvegicus	24-32
34437989-6	2021	PMA treatment increases IL-1beta and TNF-alpha levels in 15 minutes in culture and increases the release of both cytokines after 30 minutes and 24h, respectively.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Rattus norvegicus	37-46
34437989-7	2021	Both IL-1beta and TNF-alpha levels decrease after 48h of PMA treatment.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 alpha	Rattus norvegicus	5-13
34437989-7	2021	Both IL-1beta and TNF-alpha levels decrease after 48h of PMA treatment.	Tetradecanoylphorbol Acetate	57-60	tumor necrosis factor	Rattus norvegicus	18-27
34681720-3	2021	THP-1 monocytes were differentiated with phorbol 12-myristate 13-acetate (PMA) into macrophages and (i) the expression of selenoproteins, (ii) differentiation markers, (iii) the activity of NF-kappaB and NRF2, as well as (iv) lipid mediator profiles were analyzed.	Tetradecanoylphorbol Acetate	74-77	GLI family zinc finger 2	Homo sapiens	0-5
34645824-0	2021	Phorbol-12-myristate 13-acetate inhibits Nephronectin gene expression via Protein kinase C alpha and c-Jun/c-Fos transcription factors.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, alpha	Mus musculus	74-96
34645824-2	2021	A search for factors that regulate Npnt gene expression in osteoblasts revealed that phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), had a strong effect to suppress that expression.	Tetradecanoylphorbol Acetate	85-116	protein kinase C, alpha	Mus musculus	158-161
34274479-1	2021	Treatment of serum-starved quiescent human cells with fetal bovine serum (FBS), epidermal growth factor (EGF), or the phorbol ester (12-O-tetradecanoylphorbol-13-acetate, TPA) activates the RAS-MAPK pathway which initiates a transcriptional program which drives cells toward proliferation.	Tetradecanoylphorbol Acetate	133-169	plasminogen activator, tissue type	Homo sapiens	171-174
34645824-2	2021	A search for factors that regulate Npnt gene expression in osteoblasts revealed that phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), had a strong effect to suppress that expression.	Tetradecanoylphorbol Acetate	118-121	protein kinase C, alpha	Mus musculus	158-161
34542891-4	2022	Using human granulosa-like KGN cells, we confirmed that forskolin plus phorbol myristate acetate (PMA) which mimic the luteinizing hormone (LH) action induced the expression of WNT5A and cumulus expansion gene HAS2.	Tetradecanoylphorbol Acetate	71-96	Wnt family member 5A	Homo sapiens	177-182
34542891-4	2022	Using human granulosa-like KGN cells, we confirmed that forskolin plus phorbol myristate acetate (PMA) which mimic the luteinizing hormone (LH) action induced the expression of WNT5A and cumulus expansion gene HAS2.	Tetradecanoylphorbol Acetate	98-101	Wnt family member 5A	Homo sapiens	177-182
34632188-8	2021	In conclusion, 1,4-naphthoquinone is an effective inhibitor of IRAK1 kinases and their mediated inflammatory cytokines production in LPS-stimulated PMA-induced human THP-1 macrophages.	Tetradecanoylphorbol Acetate	148-151	GLI family zinc finger 2	Homo sapiens	166-171
34369554-9	2021	On the other hand, AGFG2 downregulation resulted in the inhibition of vWF secretion upon Phorbol 12-myristate 13-acetate (PMA) or histamine stimulation, suggesting that AGFG2 plays a role in vWF exocytosis.	Tetradecanoylphorbol Acetate	89-120	von Willebrand factor	Homo sapiens	191-194
34369554-9	2021	On the other hand, AGFG2 downregulation resulted in the inhibition of vWF secretion upon Phorbol 12-myristate 13-acetate (PMA) or histamine stimulation, suggesting that AGFG2 plays a role in vWF exocytosis.	Tetradecanoylphorbol Acetate	122-125	von Willebrand factor	Homo sapiens	70-73
34369554-9	2021	On the other hand, AGFG2 downregulation resulted in the inhibition of vWF secretion upon Phorbol 12-myristate 13-acetate (PMA) or histamine stimulation, suggesting that AGFG2 plays a role in vWF exocytosis.	Tetradecanoylphorbol Acetate	122-125	von Willebrand factor	Homo sapiens	191-194
34248106-7	2021	Trans-palmitoleic acid and eicosapentaenoic acid (TPA and EPA) increased the phosphorylation level of MAPK/ERK1/2 and downregulated ROS generation and Tnfaip3 expression.	Tetradecanoylphorbol Acetate	50-53	mitogen-activated protein kinase 3	Homo sapiens	102-106
34488927-9	2022	In addition, in phorbol 12-myristate 13-acetate (PMA)-treated THP-1 macrophages, PN-101 attenuated LPS-induced increase production of pro-inflammatory cytokines.	Tetradecanoylphorbol Acetate	49-52	GLI family zinc finger 2	Homo sapiens	62-67
34248106-7	2021	Trans-palmitoleic acid and eicosapentaenoic acid (TPA and EPA) increased the phosphorylation level of MAPK/ERK1/2 and downregulated ROS generation and Tnfaip3 expression.	Tetradecanoylphorbol Acetate	50-53	mitogen-activated protein kinase 3	Homo sapiens	107-113
34289257-5	2021	Interleukin (IL) 1beta, IL6, and tumor necrosis factor (TNF) alpha messenger RNA (mRNA) expressions were analyzed in freshly isolated and cultured PBMCs with phytohemagglutinin and phorbol myristate acetate stimulation by real-time reverse transcription polymerase chain reaction and serum MMP3 by enzyme-linked immunosorbent assay (ELISA).	Tetradecanoylphorbol Acetate	181-206	interleukin 6	Homo sapiens	24-27
34289257-5	2021	Interleukin (IL) 1beta, IL6, and tumor necrosis factor (TNF) alpha messenger RNA (mRNA) expressions were analyzed in freshly isolated and cultured PBMCs with phytohemagglutinin and phorbol myristate acetate stimulation by real-time reverse transcription polymerase chain reaction and serum MMP3 by enzyme-linked immunosorbent assay (ELISA).	Tetradecanoylphorbol Acetate	181-206	tumor necrosis factor	Homo sapiens	33-66
34146852-5	2021	CQ down-regulated caspase-1 (CASP1), MAPKs, and NF-kappaB levels enhanced by stimulation with PMA + A23187.	Tetradecanoylphorbol Acetate	94-97	caspase 1	Homo sapiens	18-27
34146852-5	2021	CQ down-regulated caspase-1 (CASP1), MAPKs, and NF-kappaB levels enhanced by stimulation with PMA + A23187.	Tetradecanoylphorbol Acetate	94-97	caspase 1	Homo sapiens	29-34
34146852-5	2021	CQ down-regulated caspase-1 (CASP1), MAPKs, and NF-kappaB levels enhanced by stimulation with PMA + A23187.	Tetradecanoylphorbol Acetate	94-97	nuclear factor kappa B subunit 1	Homo sapiens	48-57
34517463-3	2021	THP-1 transfected cells were induced into macrophages, lipopolysaccharide (LPS) and interferon gamma(IFNgamma) by phorbol 12-tetradecanoate 13-acetate (PMA), and then the polarized macrophages were further induced to M1 type.	Tetradecanoylphorbol Acetate	114-150	interferon gamma	Homo sapiens	84-110
34572313-0	2021	The FcgammaRIII Engagement Augments PMA-Stimulated Neutrophil Extracellular Traps (NETs) Formation by Granulocytes Partially via Cross-Talk between Syk-ERK-NF-kappaB and PKC-ROS Signaling Pathways.	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase 1	Homo sapiens	152-155
34572313-0	2021	The FcgammaRIII Engagement Augments PMA-Stimulated Neutrophil Extracellular Traps (NETs) Formation by Granulocytes Partially via Cross-Talk between Syk-ERK-NF-kappaB and PKC-ROS Signaling Pathways.	Tetradecanoylphorbol Acetate	36-39	nuclear factor kappa B subunit 1	Homo sapiens	156-165
34572313-0	2021	The FcgammaRIII Engagement Augments PMA-Stimulated Neutrophil Extracellular Traps (NETs) Formation by Granulocytes Partially via Cross-Talk between Syk-ERK-NF-kappaB and PKC-ROS Signaling Pathways.	Tetradecanoylphorbol Acetate	36-39	proline rich transmembrane protein 2	Homo sapiens	170-173
34578957-0	2021	Kaempferol Blocks the Skin Fibroblastic Interleukin 1beta Expression and Cytotoxicity Induced by 12-O-tetradecanoylphorbol-13-acetate by Suppressing c-Jun N-terminal Kinase.	Tetradecanoylphorbol Acetate	97-133	interleukin 1 beta	Homo sapiens	40-57
34578957-0	2021	Kaempferol Blocks the Skin Fibroblastic Interleukin 1beta Expression and Cytotoxicity Induced by 12-O-tetradecanoylphorbol-13-acetate by Suppressing c-Jun N-terminal Kinase.	Tetradecanoylphorbol Acetate	97-133	mitogen-activated protein kinase 8	Homo sapiens	149-172
34578957-5	2021	Kaempferol blocked the production of the intracellular reactive oxygen species (ROS) responsible for the phosphorylation of c-Jun N-terminal kinase (JNK) induced by TPA.	Tetradecanoylphorbol Acetate	165-168	mitogen-activated protein kinase 8	Homo sapiens	124-147
34578957-5	2021	Kaempferol blocked the production of the intracellular reactive oxygen species (ROS) responsible for the phosphorylation of c-Jun N-terminal kinase (JNK) induced by TPA.	Tetradecanoylphorbol Acetate	165-168	mitogen-activated protein kinase 8	Homo sapiens	149-152
34578957-6	2021	Interestingly, we found that kaempferol inhibited the phosphorylation of nuclear factor-kappa B (NF-kappaB) and the inhibitor NF-kappaB (IkappaBalpha), which are necessary for the expression of cleaved caspase-3 and the IL-1beta secretion in TPA-treated NHDF.	Tetradecanoylphorbol Acetate	242-245	nuclear factor kappa B subunit 1	Homo sapiens	73-95
34578957-6	2021	Interestingly, we found that kaempferol inhibited the phosphorylation of nuclear factor-kappa B (NF-kappaB) and the inhibitor NF-kappaB (IkappaBalpha), which are necessary for the expression of cleaved caspase-3 and the IL-1beta secretion in TPA-treated NHDF.	Tetradecanoylphorbol Acetate	242-245	nuclear factor kappa B subunit 1	Homo sapiens	97-106
34578957-6	2021	Interestingly, we found that kaempferol inhibited the phosphorylation of nuclear factor-kappa B (NF-kappaB) and the inhibitor NF-kappaB (IkappaBalpha), which are necessary for the expression of cleaved caspase-3 and the IL-1beta secretion in TPA-treated NHDF.	Tetradecanoylphorbol Acetate	242-245	NFKB inhibitor alpha	Homo sapiens	137-149
34578957-6	2021	Interestingly, we found that kaempferol inhibited the phosphorylation of nuclear factor-kappa B (NF-kappaB) and the inhibitor NF-kappaB (IkappaBalpha), which are necessary for the expression of cleaved caspase-3 and the IL-1beta secretion in TPA-treated NHDF.	Tetradecanoylphorbol Acetate	242-245	caspase 3	Homo sapiens	202-211
34572313-12	2021	In conclusion, we discovered that cross-talk between FcgammaRIII engagement-induced Syk-ERK and PMA-induced PKC signaling pathways augment NET formation of dHL-60 via increased ROS generation and pro-inflammatory cytokines, IL-8 and TNF-alpha, production.	Tetradecanoylphorbol Acetate	96-99	proline rich transmembrane protein 2	Homo sapiens	108-111
34572313-12	2021	In conclusion, we discovered that cross-talk between FcgammaRIII engagement-induced Syk-ERK and PMA-induced PKC signaling pathways augment NET formation of dHL-60 via increased ROS generation and pro-inflammatory cytokines, IL-8 and TNF-alpha, production.	Tetradecanoylphorbol Acetate	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	224-228
34572313-12	2021	In conclusion, we discovered that cross-talk between FcgammaRIII engagement-induced Syk-ERK and PMA-induced PKC signaling pathways augment NET formation of dHL-60 via increased ROS generation and pro-inflammatory cytokines, IL-8 and TNF-alpha, production.	Tetradecanoylphorbol Acetate	96-99	tumor necrosis factor	Homo sapiens	233-242
34171483-9	2021	Integrin alpha6 and beta4 expression was also reduced when alpha2 expression was chemically induced using tetradecanoyl-phorbol-acetate (TPA).	Tetradecanoylphorbol Acetate	106-135	glycoprotein hormone subunit alpha 2	Homo sapiens	59-65
34171483-9	2021	Integrin alpha6 and beta4 expression was also reduced when alpha2 expression was chemically induced using tetradecanoyl-phorbol-acetate (TPA).	Tetradecanoylphorbol Acetate	137-140	glycoprotein hormone subunit alpha 2	Homo sapiens	59-65
34517463-3	2021	THP-1 transfected cells were induced into macrophages, lipopolysaccharide (LPS) and interferon gamma(IFNgamma) by phorbol 12-tetradecanoate 13-acetate (PMA), and then the polarized macrophages were further induced to M1 type.	Tetradecanoylphorbol Acetate	152-155	interferon gamma	Homo sapiens	84-110
34184083-4	2021	M2-like TAMs were induced by treatment with PMA, plus IL-4 and IL-13, and identified by flow cytometry.	Tetradecanoylphorbol Acetate	44-47	interleukin 13	Homo sapiens	63-68
34439276-6	2021	We found that phorbol myristate acetate-induced THP-1 macrophages took up EVs-miR-21-5p from EC109 or EC9706 cells and were transformed into M2 macrophages.	Tetradecanoylphorbol Acetate	14-39	GLI family zinc finger 2	Homo sapiens	48-53
34422811-7	2021	Results: Overexpression of lncRNA TPA decreased the expression of E-cadherin, and significantly increased the expression of Vimentin, fibronectin and TGF-beta1 (p < 0.01), and increased the migration rate, migration ability and invasion ability of cell group (P < 0.01).	Tetradecanoylphorbol Acetate	34-37	cadherin 1	Mus musculus	66-76
34339458-4	2021	We demonstrate that depletion of either YAP or TAZ inhibits the ability of phorbol ester (TPA) treatment, cellular differentiation or the EBV BRLF1 immediate-early (IE) protein to induce lytic EBV reactivation in oral keratinocytes, and show that over-expression of constitutively active forms of YAP and TAZ reactivate lytic EBV infection in conjunction with TEAD family members.	Tetradecanoylphorbol Acetate	90-93	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	47-50
34382410-5	2021	Results: The expression of IFN-gamma in Lv-1645 cells was significantly increased compared to that in Jurkat-E6-1 cells stimulated by phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	134-165	interferon gamma	Homo sapiens	27-36
34382410-5	2021	Results: The expression of IFN-gamma in Lv-1645 cells was significantly increased compared to that in Jurkat-E6-1 cells stimulated by phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	167-170	interferon gamma	Homo sapiens	27-36
34382410-7	2021	Silencing PCM1 significantly increased the level of IFN-gamma in Lv-1645 cells stimulated by PMA.	Tetradecanoylphorbol Acetate	93-96	interferon gamma	Homo sapiens	52-61
34382410-8	2021	Conclusion: This study revealed that lncRNA-ENST00000421645 mediates the production of IFN-gamma by sponging PCM1 protein after PMA stimulation.	Tetradecanoylphorbol Acetate	128-131	interferon gamma	Homo sapiens	87-96
34184083-9	2021	It was found that treatment with PMA plus IL-4 and IL-13 successfully induced M2-like TAMs.	Tetradecanoylphorbol Acetate	33-36	interleukin 13	Homo sapiens	51-56
34119884-7	2021	In addition, the blockage of bypassing EGFR/AKT/NF-kB/IkB signaling pathway is greatly enhanced via elevated intracellular PMA/Fe-HSA@DOX nanoparticles (NPs).	Tetradecanoylphorbol Acetate	123-126	epidermal growth factor receptor	Homo sapiens	39-43
34119884-7	2021	In addition, the blockage of bypassing EGFR/AKT/NF-kB/IkB signaling pathway is greatly enhanced via elevated intracellular PMA/Fe-HSA@DOX nanoparticles (NPs).	Tetradecanoylphorbol Acetate	123-126	AKT serine/threonine kinase 1	Homo sapiens	44-47
34114342-5	2021	The NF-kB /AP-1 transcription factors mediated effects of LPS and TPA on 20alpha-HSD gene transcription.	Tetradecanoylphorbol Acetate	66-69	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	11-15
34252035-5	2021	PKC activation with phorbol 12-myristate 13-acetate (PMA) increased receptor activity only in cells coexpressing GluN1/GluN2A and alpha2delta-1.	Tetradecanoylphorbol Acetate	20-51	proline rich transmembrane protein 2	Homo sapiens	0-3
34252035-5	2021	PKC activation with phorbol 12-myristate 13-acetate (PMA) increased receptor activity only in cells coexpressing GluN1/GluN2A and alpha2delta-1.	Tetradecanoylphorbol Acetate	53-56	proline rich transmembrane protein 2	Homo sapiens	0-3
34252035-7	2021	Treatment with PMA increased the alpha2delta-1-GluN1 interaction and promoted alpha2delta-1 and GluN1 cell surface trafficking.	Tetradecanoylphorbol Acetate	15-18	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	47-52
34252035-7	2021	Treatment with PMA increased the alpha2delta-1-GluN1 interaction and promoted alpha2delta-1 and GluN1 cell surface trafficking.	Tetradecanoylphorbol Acetate	15-18	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	96-101
34512147-7	2021	We further demonstrate that c-Jun, AR, and DNA methyltransferase-1 (DNMT1) form a complex in the 12-O-tetradecanoyl phorbol-13-acetate (TPA) response elements (TREs) region of the NDRG1 promoter, which suppresses NDRG1 transcription through DNA hypermethylation.	Tetradecanoylphorbol Acetate	136-139	androgen receptor	Homo sapiens	35-37
34126553-7	2021	TNF-alpha was expressed by CD14+ monocytes after LPS stimulation and by monocytes and lymphocytes after polyclonal stimulation with PMA and ionomycin in vitro.	Tetradecanoylphorbol Acetate	132-135	tumor necrosis factor	Equus caballus	0-9
34512147-7	2021	We further demonstrate that c-Jun, AR, and DNA methyltransferase-1 (DNMT1) form a complex in the 12-O-tetradecanoyl phorbol-13-acetate (TPA) response elements (TREs) region of the NDRG1 promoter, which suppresses NDRG1 transcription through DNA hypermethylation.	Tetradecanoylphorbol Acetate	97-134	androgen receptor	Homo sapiens	35-37
34458835-6	2021	Both constrained peptides downregulate PMA-induced cytoskeletal remodeling that is mediated by the PKC-gravin complex as measured by cell rounding.	Tetradecanoylphorbol Acetate	39-42	proline rich transmembrane protein 2	Homo sapiens	99-102
34201732-6	2021	The two extracts have been used to treat ex vivo neutrophils from subjects with metabolic syndrome, reporting a marked antioxidant activity of Taurisolo , as shown by its ability to significantly reduce both the levels of reactive oxygen species (ROS) and the activities of catalase and myeloperoxidase in the cell medium after stimulation of neutrophils with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	393-396	catalase	Homo sapiens	274-282
34093777-6	2021	The results demonstrated that triptolide decreased the expression of MMP-9 through inhibition of the TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK) and the downregulation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) activity.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase 1	Homo sapiens	132-169
34093777-6	2021	The results demonstrated that triptolide decreased the expression of MMP-9 through inhibition of the TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK) and the downregulation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) activity.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase 1	Homo sapiens	171-174
34093777-6	2021	The results demonstrated that triptolide decreased the expression of MMP-9 through inhibition of the TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK) and the downregulation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) activity.	Tetradecanoylphorbol Acetate	101-104	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	240-259
34201732-6	2021	The two extracts have been used to treat ex vivo neutrophils from subjects with metabolic syndrome, reporting a marked antioxidant activity of Taurisolo , as shown by its ability to significantly reduce both the levels of reactive oxygen species (ROS) and the activities of catalase and myeloperoxidase in the cell medium after stimulation of neutrophils with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	393-396	myeloperoxidase	Homo sapiens	287-302
34201732-8	2021	In addition, Taurisolo  reversed the increase in malondialdehyde induced by PMA; reduced the expression of pro-inflammatory genes such as cyclooxygenase 2 (COX-2), tumor necrosis factor alpha (TNFalpha) and myeloperoxidase (MPO); and induced the expression of the anti-inflammatory cytokine IL-10.	Tetradecanoylphorbol Acetate	76-79	tumor necrosis factor	Homo sapiens	164-191
34201732-8	2021	In addition, Taurisolo  reversed the increase in malondialdehyde induced by PMA; reduced the expression of pro-inflammatory genes such as cyclooxygenase 2 (COX-2), tumor necrosis factor alpha (TNFalpha) and myeloperoxidase (MPO); and induced the expression of the anti-inflammatory cytokine IL-10.	Tetradecanoylphorbol Acetate	76-79	tumor necrosis factor	Homo sapiens	193-201
34201732-8	2021	In addition, Taurisolo  reversed the increase in malondialdehyde induced by PMA; reduced the expression of pro-inflammatory genes such as cyclooxygenase 2 (COX-2), tumor necrosis factor alpha (TNFalpha) and myeloperoxidase (MPO); and induced the expression of the anti-inflammatory cytokine IL-10.	Tetradecanoylphorbol Acetate	76-79	myeloperoxidase	Homo sapiens	207-222
34201732-8	2021	In addition, Taurisolo  reversed the increase in malondialdehyde induced by PMA; reduced the expression of pro-inflammatory genes such as cyclooxygenase 2 (COX-2), tumor necrosis factor alpha (TNFalpha) and myeloperoxidase (MPO); and induced the expression of the anti-inflammatory cytokine IL-10.	Tetradecanoylphorbol Acetate	76-79	myeloperoxidase	Homo sapiens	224-227
34135065-6	2021	In humans, CD4+ T cells from rs8005161 heterozygous individuals expressed higher levels of TNF-alpha after PMA/ionomycin stimulation, particularly under pH 6 conditions.	Tetradecanoylphorbol Acetate	107-110	CD4 molecule	Homo sapiens	11-14
34135065-6	2021	In humans, CD4+ T cells from rs8005161 heterozygous individuals expressed higher levels of TNF-alpha after PMA/ionomycin stimulation, particularly under pH 6 conditions.	Tetradecanoylphorbol Acetate	107-110	tumor necrosis factor	Homo sapiens	91-100
34234780-0	2021	Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation.	Tetradecanoylphorbol Acetate	77-108	GLI family zinc finger 2	Homo sapiens	118-123
34204745-11	2021	Furthermore, the XN-treatment counteracted the PMA-induced EMT of the A549 cells by the upregulation of E-cadherin and alpha-E-catenin and the downregulation of N-cadherin, vimentin, and Snail-1 expression.	Tetradecanoylphorbol Acetate	47-50	cadherin 1	Homo sapiens	104-114
34198661-5	2021	The gene expression of catalase and TNFalpha was enhanced by phorbol myristate acetate (PMA) only in the placebo group, while the glutathione peroxidase expression was enhanced by PMA only after nitrate intake.	Tetradecanoylphorbol Acetate	61-86	catalase	Homo sapiens	23-31
34198661-5	2021	The gene expression of catalase and TNFalpha was enhanced by phorbol myristate acetate (PMA) only in the placebo group, while the glutathione peroxidase expression was enhanced by PMA only after nitrate intake.	Tetradecanoylphorbol Acetate	61-86	tumor necrosis factor	Homo sapiens	36-44
34198661-5	2021	The gene expression of catalase and TNFalpha was enhanced by phorbol myristate acetate (PMA) only in the placebo group, while the glutathione peroxidase expression was enhanced by PMA only after nitrate intake.	Tetradecanoylphorbol Acetate	88-91	catalase	Homo sapiens	23-31
34198661-5	2021	The gene expression of catalase and TNFalpha was enhanced by phorbol myristate acetate (PMA) only in the placebo group, while the glutathione peroxidase expression was enhanced by PMA only after nitrate intake.	Tetradecanoylphorbol Acetate	88-91	tumor necrosis factor	Homo sapiens	36-44
34198661-5	2021	The gene expression of catalase and TNFalpha was enhanced by phorbol myristate acetate (PMA) only in the placebo group, while the glutathione peroxidase expression was enhanced by PMA only after nitrate intake.	Tetradecanoylphorbol Acetate	180-183	catalase	Homo sapiens	23-31
34198661-5	2021	The gene expression of catalase and TNFalpha was enhanced by phorbol myristate acetate (PMA) only in the placebo group, while the glutathione peroxidase expression was enhanced by PMA only after nitrate intake.	Tetradecanoylphorbol Acetate	180-183	tumor necrosis factor	Homo sapiens	36-44
34204745-11	2021	Furthermore, the XN-treatment counteracted the PMA-induced EMT of the A549 cells by the upregulation of E-cadherin and alpha-E-catenin and the downregulation of N-cadherin, vimentin, and Snail-1 expression.	Tetradecanoylphorbol Acetate	47-50	snail family transcriptional repressor 1	Homo sapiens	187-194
35569521-5	2022	Briefly, larixol inhibited fMLP (0.1 muM)-induced superoxide anion production (IC50:1.98 +- 0.14 muM), the release of cathepsin G (IC50:2.76 +- 0.15 muM) and chemotaxis in a concentration-dependent manner; however, larixol did not inhibit these functions induced by PMA (100 nM).	Tetradecanoylphorbol Acetate	266-269	formyl peptide receptor 1	Homo sapiens	27-31
33290316-8	2021	The inhibition of MEK and ERK was confirmed by using MEK stimulators, GM-CSF and phorbol 12-myristate 13-acetate, and MEK-specific inhibitor, PD98059.	Tetradecanoylphorbol Acetate	81-112	mitogen-activated protein kinase kinase 7	Homo sapiens	18-21
33290316-8	2021	The inhibition of MEK and ERK was confirmed by using MEK stimulators, GM-CSF and phorbol 12-myristate 13-acetate, and MEK-specific inhibitor, PD98059.	Tetradecanoylphorbol Acetate	81-112	mitogen-activated protein kinase 1	Homo sapiens	26-29
34152310-3	2021	We reason that combination of RB dye (50 mg/kg) and a sub-thrombotic dose of thrombin (80 U/kg) for photoactivation aimed at the proximal branch of middle cerebral artery (MCA) may produce fibrin-enriched and tPA-sensitive clots.	Tetradecanoylphorbol Acetate	209-212	coagulation factor II, thrombin	Homo sapiens	77-85
34134956-9	2021	PMA mimicked the effect of orexin-A in these neurons and significantly inhibited GABA currents with an inhibition rate of (60.79+-10.94)%, and the application of orexin-A did not cause further suppression of GABA currents in PMA-treated neurons (P=0.15, n=6).	Tetradecanoylphorbol Acetate	0-3	hypocretin neuropeptide precursor	Rattus norvegicus	27-35
35608955-4	2022	In contrast, following TCR-independent activation using PMA/ionomycin, neonatal cells demonstrated increased expression of CD69, IL-2 and TNF- alpha and equivalent phosphoERK compared to adult cells.	Tetradecanoylphorbol Acetate	56-59	interleukin 2	Homo sapiens	129-133
35608955-4	2022	In contrast, following TCR-independent activation using PMA/ionomycin, neonatal cells demonstrated increased expression of CD69, IL-2 and TNF- alpha and equivalent phosphoERK compared to adult cells.	Tetradecanoylphorbol Acetate	56-59	tumor necrosis factor	Homo sapiens	138-148
35604451-4	2022	DNA microarrays and in vitro cell studies showed that exogenous miR16 and its mimic treatment, in LPS/PMA induced monocytes, significantly downregulated several ARE containing inflammatory cytokine mRNAs similar to those seen in the normal monocytes.	Tetradecanoylphorbol Acetate	102-105	glycerophosphodiester phosphodiesterase 1	Homo sapiens	64-69
35572500-5	2022	To explore the roles and mechanism of TIPE2 in M1 polarization of macrophages, THP-1 monocytes stimulated with phorbol-12-myristate-13-acetate, were used as a model of undifferentiated (M0) macrophages, and M0 macrophages were treated with lipopolysaccharide to induce M1 macrophages.	Tetradecanoylphorbol Acetate	111-142	GLI family zinc finger 2	Homo sapiens	79-84
35471587-7	2022	An inducer of keratinocyte differentiation, phorbol 12-myristate 13-acetate (PMA), also diminished TXNIP expression, which was reversed by PKC-delta knockdown.	Tetradecanoylphorbol Acetate	44-75	thioredoxin interacting protein	Homo sapiens	99-104
35471587-7	2022	An inducer of keratinocyte differentiation, phorbol 12-myristate 13-acetate (PMA), also diminished TXNIP expression, which was reversed by PKC-delta knockdown.	Tetradecanoylphorbol Acetate	77-80	thioredoxin interacting protein	Homo sapiens	99-104
35471587-8	2022	TXNIP knockdown reduced PMA-induced involucrin and transglutaminse-1 expression, and increased p63 expression in NHEKs but did not significantly affect cell proliferation.	Tetradecanoylphorbol Acetate	24-27	thioredoxin interacting protein	Homo sapiens	0-5
35471587-10	2022	Furthermore, PMA-induced PKC-delta phosphorylation, TGF-alpha, and EGF-triggered EGFR phosphorylation were attenuated by TXNIP knockdown.	Tetradecanoylphorbol Acetate	13-16	epidermal growth factor receptor	Homo sapiens	81-85
35471587-10	2022	Furthermore, PMA-induced PKC-delta phosphorylation, TGF-alpha, and EGF-triggered EGFR phosphorylation were attenuated by TXNIP knockdown.	Tetradecanoylphorbol Acetate	13-16	thioredoxin interacting protein	Homo sapiens	121-126
35567654-9	2022	Although SOD activity was the highest (P < 0.05) in PMA-induced cells, a silica-induced reduction in cell adhesion was observed only in those cells (P < 0.05).	Tetradecanoylphorbol Acetate	52-55	superoxide dismutase 1	Homo sapiens	9-12
35475990-6	2022	In our in vitro assays, quercetin reduced NETs, myeloperoxidase (MPO), and elastase release from neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	125-156	myeloperoxidase	Homo sapiens	65-68
35475990-6	2022	In our in vitro assays, quercetin reduced NETs, myeloperoxidase (MPO), and elastase release from neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	158-161	myeloperoxidase	Homo sapiens	48-63
35475990-6	2022	In our in vitro assays, quercetin reduced NETs, myeloperoxidase (MPO), and elastase release from neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	125-156	myeloperoxidase	Homo sapiens	48-63
35383599-19	2022	TPA and GT increased with PI (Pr>0.9999) and age after 35 years (Pr>0.9999).	Tetradecanoylphorbol Acetate	0-3	renin binding protein	Homo sapiens	45-48
35177210-3	2022	The expression of GPR3 was upregulated 2 h after phorbol 12-myristate 13-acetate (PMA)/ionomycin stimulation and was sustained in Jurkat cells, a human T lymphocyte cell line.	Tetradecanoylphorbol Acetate	49-80	G protein-coupled receptor 3	Homo sapiens	18-22
35612375-4	2022	In this study, we found that pro-inflammatory cytokines-IL-1beta, IL-6 and TNFalpha showed greater induction in phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells than in THP-1 cells.	Tetradecanoylphorbol Acetate	112-143	interleukin 6	Homo sapiens	66-70
35612375-4	2022	In this study, we found that pro-inflammatory cytokines-IL-1beta, IL-6 and TNFalpha showed greater induction in phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells than in THP-1 cells.	Tetradecanoylphorbol Acetate	112-143	tumor necrosis factor	Homo sapiens	75-83
35612375-4	2022	In this study, we found that pro-inflammatory cytokines-IL-1beta, IL-6 and TNFalpha showed greater induction in phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells than in THP-1 cells.	Tetradecanoylphorbol Acetate	145-148	interleukin 6	Homo sapiens	66-70
35612375-4	2022	In this study, we found that pro-inflammatory cytokines-IL-1beta, IL-6 and TNFalpha showed greater induction in phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells than in THP-1 cells.	Tetradecanoylphorbol Acetate	145-148	tumor necrosis factor	Homo sapiens	75-83
35146909-6	2022	This process can be effectively inhibited by dexamethasone and accompanied by the continuous low levels of MPO in the nucleus after PMA stimulation.	Tetradecanoylphorbol Acetate	132-135	myeloperoxidase	Homo sapiens	107-110
35222701-6	2022	Finally, the physiological processes of lipopolysaccharide (LPS)-induced hPDLSCs overexpressing HMBOX1 were assessed following treatment with phorbol 12-myristate 13-acetate (PMA), a NF-kappaB agonist.	Tetradecanoylphorbol Acetate	142-173	nuclear factor kappa B subunit 1	Homo sapiens	183-192
35197329-0	2022	Aberrant HO-1/NQO1-Reactive Oxygen Species-ERK Signaling Pathway Contributes to Aggravation of TPA-Induced Irritant Contact Dermatitis in Nrf2-Deficient Mice.	Tetradecanoylphorbol Acetate	95-98	heme oxygenase 1	Mus musculus	9-13
35197329-0	2022	Aberrant HO-1/NQO1-Reactive Oxygen Species-ERK Signaling Pathway Contributes to Aggravation of TPA-Induced Irritant Contact Dermatitis in Nrf2-Deficient Mice.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 1	Mus musculus	43-46
35197329-0	2022	Aberrant HO-1/NQO1-Reactive Oxygen Species-ERK Signaling Pathway Contributes to Aggravation of TPA-Induced Irritant Contact Dermatitis in Nrf2-Deficient Mice.	Tetradecanoylphorbol Acetate	95-98	nuclear factor, erythroid derived 2, like 2	Mus musculus	138-142
35197329-4	2022	In this article, we elucidated the role of Nrf2 in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced acute ICD.	Tetradecanoylphorbol Acetate	89-92	nuclear factor, erythroid derived 2, like 2	Mus musculus	43-47
35197329-8	2022	Inhibition of ERK significantly alleviated TPA-induced cutaneous inflammation and ROS accumulation in MEFs derived from mouse.	Tetradecanoylphorbol Acetate	43-46	mitogen-activated protein kinase 1	Mus musculus	14-17
35197329-10	2022	Taken together, the findings illustrate the key role of the Nrf2/ROS/ERK signaling pathway in TPA-induced acute ICD.	Tetradecanoylphorbol Acetate	94-97	nuclear factor, erythroid derived 2, like 2	Mus musculus	60-64
35197329-10	2022	Taken together, the findings illustrate the key role of the Nrf2/ROS/ERK signaling pathway in TPA-induced acute ICD.	Tetradecanoylphorbol Acetate	94-97	mitogen-activated protein kinase 1	Mus musculus	69-72
35177210-3	2022	The expression of GPR3 was upregulated 2 h after phorbol 12-myristate 13-acetate (PMA)/ionomycin stimulation and was sustained in Jurkat cells, a human T lymphocyte cell line.	Tetradecanoylphorbol Acetate	82-85	G protein-coupled receptor 3	Homo sapiens	18-22
35484745-9	2022	In conclusion, AuNPs-CIT inhibits PMA-induced TNF-alpha mRNA and protein expression via deactivation of NF-kappaB signaling in breast cancer cells.	Tetradecanoylphorbol Acetate	34-37	tumor necrosis factor	Homo sapiens	46-55
35150402-5	2022	Human THP-1 monocyte was differentiated into macrophages with phorbol myristate acetate, which were further identified by transmission electron microscopy and western blot.	Tetradecanoylphorbol Acetate	62-87	GLI family zinc finger 2	Homo sapiens	6-11
35108538-5	2022	In the absence of ACKR4, migration of T cells to dLNs in TPA-induced inflammation is significantly reduced.	Tetradecanoylphorbol Acetate	57-60	atypical chemokine receptor 4	Homo sapiens	18-23
35401828-4	2022	Furthermore, conditional PINCH-1 knockout mouse and carcinogen (7, 12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA))-induced skin cancer model were employed to determine the function of PINCH-1 in regulation of IGF-1R expression and skin carcinogenesis in vivo.	Tetradecanoylphorbol Acetate	141-144	insulin-like growth factor I receptor	Mus musculus	241-247
35401828-9	2022	Using a mouse model of DMBA/TPA-induced skin cancer, we show that the levels of both PINCH-1 and IGF-1R were significantly increased in response to treatment with the carcinogens.	Tetradecanoylphorbol Acetate	28-31	insulin-like growth factor I receptor	Mus musculus	97-103
35103281-8	2022	Treatment with phorbol 12-myristate 13-acetate, a PKC activator, rescued the cell viability.	Tetradecanoylphorbol Acetate	15-46	protein kinase C, alpha	Mus musculus	50-53
35484745-9	2022	In conclusion, AuNPs-CIT inhibits PMA-induced TNF-alpha mRNA and protein expression via deactivation of NF-kappaB signaling in breast cancer cells.	Tetradecanoylphorbol Acetate	34-37	nuclear factor kappa B subunit 1	Homo sapiens	104-113
35087193-2	2022	In this study, we describe a selective non-steroidal glucocorticoid receptor (GR) agonist for topical use, LEO 134310, which is rapidly deactivated in the blood resulting in low systemic exposure and a higher therapeutic index in the TPA-induced skin inflammation mouse model compared with betamethasone valerate (BMV) and clobetasol propionate (CP).	Tetradecanoylphorbol Acetate	234-237	nuclear receptor subfamily 3, group C, member 1	Mus musculus	53-76
35087193-2	2022	In this study, we describe a selective non-steroidal glucocorticoid receptor (GR) agonist for topical use, LEO 134310, which is rapidly deactivated in the blood resulting in low systemic exposure and a higher therapeutic index in the TPA-induced skin inflammation mouse model compared with betamethasone valerate (BMV) and clobetasol propionate (CP).	Tetradecanoylphorbol Acetate	234-237	nuclear receptor subfamily 3, group C, member 1	Mus musculus	78-80
35068054-5	2022	Mechanistic analyses suggested that the PPP2CB deletion enhanced activation of the PI3K/Akt signaling pathway and Ca2+ flux following stimulation with PMA plus ionomycin.	Tetradecanoylphorbol Acetate	151-154	thymoma viral proto-oncogene 1	Mus musculus	88-91
35072213-5	2022	Phytohaemagglutinin-induced release of pro-inflammatory mediators from PBMCs and production of intracellular cytokines by CD4+ and CD8+ T cells stimulated with phorbol 12-myristate 13-acetate and ionomycin in the presence or absence of 10 mug/mL azithromycin and 10 nM budesonide were determined using enzyme linked immunosorbent assay and flow cytometry.	Tetradecanoylphorbol Acetate	160-191	CD4 molecule	Homo sapiens	122-125
35140721-6	2022	Moreover, the 3D culture system was more suitable for the observation of neutrophil extracellular traps (NETs) stimulated by the classical stimulation phorbol ester (PMA), and other damage associated molecular patterns (DAMPs) such as Lipopolysaccharide (LPS)/ATP, interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) than the 2D culture system.	Tetradecanoylphorbol Acetate	166-169	interleukin 1 beta	Homo sapiens	265-283
35140721-6	2022	Moreover, the 3D culture system was more suitable for the observation of neutrophil extracellular traps (NETs) stimulated by the classical stimulation phorbol ester (PMA), and other damage associated molecular patterns (DAMPs) such as Lipopolysaccharide (LPS)/ATP, interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) than the 2D culture system.	Tetradecanoylphorbol Acetate	166-169	tumor necrosis factor	Homo sapiens	299-326
35068054-0	2022	Protein phosphatase 2A catalytic subunit beta suppresses PMA/ionomycin-induced T-cell activation by negatively regulating PI3K/Akt signaling.	Tetradecanoylphorbol Acetate	57-60	thymoma viral proto-oncogene 1	Mus musculus	127-130
35068054-4	2022	Furthermore, PPP2CB deletion did not affect T cell receptor (TCR)-induced T cell activation or cytokine-induced T cell responses; however, it specifically enhanced phorbol myristate acetate (PMA) plus ionomycin-induced T cell activation with increased cellular proliferation, elevated CD69 and CD25 expression, and enhanced cytokines production (IFN-gamma, IL-2 and TNF).	Tetradecanoylphorbol Acetate	164-189	interferon gamma	Mus musculus	346-355
35140721-6	2022	Moreover, the 3D culture system was more suitable for the observation of neutrophil extracellular traps (NETs) stimulated by the classical stimulation phorbol ester (PMA), and other damage associated molecular patterns (DAMPs) such as Lipopolysaccharide (LPS)/ATP, interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) than the 2D culture system.	Tetradecanoylphorbol Acetate	166-169	tumor necrosis factor	Homo sapiens	328-336
35068054-4	2022	Furthermore, PPP2CB deletion did not affect T cell receptor (TCR)-induced T cell activation or cytokine-induced T cell responses; however, it specifically enhanced phorbol myristate acetate (PMA) plus ionomycin-induced T cell activation with increased cellular proliferation, elevated CD69 and CD25 expression, and enhanced cytokines production (IFN-gamma, IL-2 and TNF).	Tetradecanoylphorbol Acetate	164-189	tumor necrosis factor	Mus musculus	366-369
35043283-7	2022	The suppressive effects of FX on TPA-enhancedSAM/SAH was abrogated by Nfe2l2 KD indicating Nfe2l2 plays a critical role in FX-mediated metabolic rewiring and its potential consequences on epigenetic reprogramming.	Tetradecanoylphorbol Acetate	33-36	NFE2 like bZIP transcription factor 2	Homo sapiens	70-76
35127555-9	2021	Higher level of CD69, ICOS and PD-1, lower level of CD62L, and decreased IFN-gamma producing after stimulation by PMA and ionomycin were found in gammadeltaT cells from infected mice, compared with naive mice.	Tetradecanoylphorbol Acetate	114-117	programmed cell death 1	Mus musculus	31-35
35127555-9	2021	Higher level of CD69, ICOS and PD-1, lower level of CD62L, and decreased IFN-gamma producing after stimulation by PMA and ionomycin were found in gammadeltaT cells from infected mice, compared with naive mice.	Tetradecanoylphorbol Acetate	114-117	selectin, lymphocyte	Mus musculus	52-57
35127555-9	2021	Higher level of CD69, ICOS and PD-1, lower level of CD62L, and decreased IFN-gamma producing after stimulation by PMA and ionomycin were found in gammadeltaT cells from infected mice, compared with naive mice.	Tetradecanoylphorbol Acetate	114-117	interferon gamma	Mus musculus	73-82
35043283-7	2022	The suppressive effects of FX on TPA-enhancedSAM/SAH was abrogated by Nfe2l2 KD indicating Nfe2l2 plays a critical role in FX-mediated metabolic rewiring and its potential consequences on epigenetic reprogramming.	Tetradecanoylphorbol Acetate	33-36	NFE2 like bZIP transcription factor 2	Homo sapiens	91-97
35043283-9	2022	Transcriptomic RNA-seq showed that FX abrogated TPA-induced differentially expressed genes (DEGs) of Nfe2l2-related genes Nqo1, Ho1, and Keap1.	Tetradecanoylphorbol Acetate	48-51	NFE2 like bZIP transcription factor 2	Homo sapiens	101-107
35043283-9	2022	Transcriptomic RNA-seq showed that FX abrogated TPA-induced differentially expressed genes (DEGs) of Nfe2l2-related genes Nqo1, Ho1, and Keap1.	Tetradecanoylphorbol Acetate	48-51	NAD(P)H quinone dehydrogenase 1	Homo sapiens	122-126
35043283-9	2022	Transcriptomic RNA-seq showed that FX abrogated TPA-induced differentially expressed genes (DEGs) of Nfe2l2-related genes Nqo1, Ho1, and Keap1.	Tetradecanoylphorbol Acetate	48-51	kelch like ECH associated protein 1	Homo sapiens	137-142
35043283-12	2022	In this context, FX/Nfe2l2"s redox signaling drives metabolic rewiring causing epigenetic and transcriptomic reprogramming potentially contributing to the protection of TPA-induced JB6 cellular transformation skin cancer model.	Tetradecanoylphorbol Acetate	169-172	NFE2 like bZIP transcription factor 2	Homo sapiens	20-26
35095881-8	2021	Patients bearing effector memory CD4 and CD8 T cells with the phenotype of high MD exhibited poorer T-cell responses upon either phorbol 12-myristate-13-acetate (PMA)/ionomycin or SARS-CoV-2 peptide stimulation than those with low MD.	Tetradecanoylphorbol Acetate	129-160	CD4 molecule	Homo sapiens	33-36
35041707-4	2022	CD4+ T cells from people living with HIV and from SIV+ rhesus macaques (RM) on antiretroviral therapy (ART) exposed in vitro to 25 nM of GSK445A produced cell-associated viral transcripts as well as viral particles at levels similar to those induced by PMA/Ionomycin, indicating that GSK445A can potently reverse HIV/SIV latency.	Tetradecanoylphorbol Acetate	253-256	CD4 molecule	Homo sapiens	0-3
35095881-8	2021	Patients bearing effector memory CD4 and CD8 T cells with the phenotype of high MD exhibited poorer T-cell responses upon either phorbol 12-myristate-13-acetate (PMA)/ionomycin or SARS-CoV-2 peptide stimulation than those with low MD.	Tetradecanoylphorbol Acetate	162-165	CD4 molecule	Homo sapiens	33-36
35087488-3	2021	PMA-induced differentiation in these cells recapitulates steps of megakaryopoiesis including gene activation, expression of CD41/61 and CD61 platelet surface markers and accumulation of intracellular reactive oxygen species (ROS).	Tetradecanoylphorbol Acetate	0-3	integrin subunit beta 3	Homo sapiens	136-140
2513128-1	1989	c-Jun, Jun-B, and Jun-D proteins bind to the TPA response element (TRE) either as homodimers or as Jun-Fos heterodimers.	Tetradecanoylphorbol Acetate	45-48	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	7-12
35271779-8	2022	Additionally, it was first determined that the knockdown of the transcription factor forkhead box O1 (FOXO1) significantly suppressed TPA-elicited SOD3 induction.	Tetradecanoylphorbol Acetate	134-137	forkhead box O1	Homo sapiens	85-100
35271779-8	2022	Additionally, it was first determined that the knockdown of the transcription factor forkhead box O1 (FOXO1) significantly suppressed TPA-elicited SOD3 induction.	Tetradecanoylphorbol Acetate	134-137	forkhead box O1	Homo sapiens	102-107
35271779-8	2022	Additionally, it was first determined that the knockdown of the transcription factor forkhead box O1 (FOXO1) significantly suppressed TPA-elicited SOD3 induction.	Tetradecanoylphorbol Acetate	134-137	superoxide dismutase 3	Homo sapiens	147-151
2513129-2	1989	jun-B is less potent that c-jun in transforming and immortalizing primary rat embryo cells in cooperation with activated ras (effects enhanced by c-fos and TPA); unlike c-jun, jun-B does not transform Rat-1A cells alone.	Tetradecanoylphorbol Acetate	156-159	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
2555061-7	1989	In contrast to the CCRF-CEM cells in culture, which expressed cytoplasmic CD3 (T3) but not surface CD3, both s.c. and metastatic CCRF-CEM line was exposed to phorbol-12-myristate 13-acetate in vitro to mimic the apparent differentiation which occurred in the xenografted cells, and a similar expression of surface CD3 after treatment was seen.	Tetradecanoylphorbol Acetate	158-189	CD247 antigen	Mus musculus	74-77
2559720-8	1989	Phorbol 12-myristate 13-acetate (PMA) inhibited by 50% the neurotensin effects on both intracellular Ca2+ and inositol phosphate levels.	Tetradecanoylphorbol Acetate	0-31	neurotensin	Homo sapiens	59-70
2483604-0	1989	Effects of phorbol myristate acetate on interleukin-2 and accompanying interferon production of human leukocytes induced by heat-inactivated Staphylococcus aureus.	Tetradecanoylphorbol Acetate	11-36	interleukin 2	Homo sapiens	40-53
2559720-8	1989	Phorbol 12-myristate 13-acetate (PMA) inhibited by 50% the neurotensin effects on both intracellular Ca2+ and inositol phosphate levels.	Tetradecanoylphorbol Acetate	33-36	neurotensin	Homo sapiens	59-70
2511200-5	1989	Preincubation with phorbol myristate acetate (TPA, 5 x 10(-8) M) for at least 4-6 h and up to 12 h followed by 3 h of LPS treatment induced a 4-fold enhancement in the accumulation of IL-1 beta transcripts compared to treatment with TPA alone.	Tetradecanoylphorbol Acetate	19-44	interleukin 1 beta	Homo sapiens	184-193
2511200-5	1989	Preincubation with phorbol myristate acetate (TPA, 5 x 10(-8) M) for at least 4-6 h and up to 12 h followed by 3 h of LPS treatment induced a 4-fold enhancement in the accumulation of IL-1 beta transcripts compared to treatment with TPA alone.	Tetradecanoylphorbol Acetate	46-49	interleukin 1 beta	Homo sapiens	184-193
2511200-5	1989	Preincubation with phorbol myristate acetate (TPA, 5 x 10(-8) M) for at least 4-6 h and up to 12 h followed by 3 h of LPS treatment induced a 4-fold enhancement in the accumulation of IL-1 beta transcripts compared to treatment with TPA alone.	Tetradecanoylphorbol Acetate	233-236	interleukin 1 beta	Homo sapiens	184-193
2511200-13	1989	The present findings thus suggest: 1) that TPA induces LPS responsiveness in U937 cells via de novo synthesis of Gi2; 2) that the LPS response (enhanced IL-1 production) is linked to a pertussis toxin-sensitive G protein which we identified as Gi2; and 3) that LPS leads to phosphorylation of Gi2.	Tetradecanoylphorbol Acetate	43-46	interleukin 1 beta	Homo sapiens	153-157
2483604-1	1989	Interleukin-2 (IL-2) production induced by heat--inactivated Staphylococcus aureus (SAU) was enhanced by simultaneous addition of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	130-155	interleukin 2	Homo sapiens	0-13
2483604-1	1989	Interleukin-2 (IL-2) production induced by heat--inactivated Staphylococcus aureus (SAU) was enhanced by simultaneous addition of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	157-160	interleukin 2	Homo sapiens	0-13
2575077-1	1989	A mixture of phorbol myristate acetate (PMA) and ionomycin was found to stimulate spleen and lymph node cells (LNC) from 6 to 8 week-old-athymic BALB/c nude mice, as well as from control +/+ mice, to secrete interleukin-3 (IL-3) in vitro.	Tetradecanoylphorbol Acetate	40-43	interleukin 3	Mus musculus	223-227
2555296-4	1989	In contrast to lymphocytic cells where the nuclear factors recognizing the kappa B sequences are activated by both tumor necrosis factor-alpha and phorbol-12-myristate-13-acetate through a posttranslational mechanism, in HepG2 cells phorbol-12-myristate-13-acetate does not activate these factor(s), and de novo protein synthesis seems to be required in HepG2 cells for gene activation by tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	147-178	tumor necrosis factor	Homo sapiens	389-416
2555296-4	1989	In contrast to lymphocytic cells where the nuclear factors recognizing the kappa B sequences are activated by both tumor necrosis factor-alpha and phorbol-12-myristate-13-acetate through a posttranslational mechanism, in HepG2 cells phorbol-12-myristate-13-acetate does not activate these factor(s), and de novo protein synthesis seems to be required in HepG2 cells for gene activation by tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	233-264	tumor necrosis factor	Homo sapiens	115-142
2575488-3	1989	We demonstrate that TPA (phorbol-12-myristate-13-acetate) stimulates the phosphorylation of p185c-neu on serine and threonine residues coincident with the inhibition of its intrinsic tyrosine kinase and the proliferation of cells that express it.	Tetradecanoylphorbol Acetate	25-56	plasminogen activator, tissue type	Homo sapiens	20-23
2482456-6	1989	By contrast, the stimulations of the PRL gene expression induced by TRH or by the phorbol ester TPA were not abolished by the calcium channel antagonist PN 200-110 whereas treatments combining TRH or TPA with BAY K8644 revealed the absence of any additive effect.	Tetradecanoylphorbol Acetate	96-99	prolactin	Rattus norvegicus	37-40
2575077-1	1989	A mixture of phorbol myristate acetate (PMA) and ionomycin was found to stimulate spleen and lymph node cells (LNC) from 6 to 8 week-old-athymic BALB/c nude mice, as well as from control +/+ mice, to secrete interleukin-3 (IL-3) in vitro.	Tetradecanoylphorbol Acetate	13-38	interleukin 3	Mus musculus	208-221
2575077-1	1989	A mixture of phorbol myristate acetate (PMA) and ionomycin was found to stimulate spleen and lymph node cells (LNC) from 6 to 8 week-old-athymic BALB/c nude mice, as well as from control +/+ mice, to secrete interleukin-3 (IL-3) in vitro.	Tetradecanoylphorbol Acetate	13-38	interleukin 3	Mus musculus	223-227
2575077-1	1989	A mixture of phorbol myristate acetate (PMA) and ionomycin was found to stimulate spleen and lymph node cells (LNC) from 6 to 8 week-old-athymic BALB/c nude mice, as well as from control +/+ mice, to secrete interleukin-3 (IL-3) in vitro.	Tetradecanoylphorbol Acetate	40-43	interleukin 3	Mus musculus	208-221
2481153-6	1989	Cultured BCEs secreted both tissue-type and urokinase-type PAs (tPA and uPA) and PAI-1 into the culture medium, and the secretion of both PAs was enhanced by the addition of bFGF.	Tetradecanoylphorbol Acetate	64-67	fibroblast growth factor 2	Bos taurus	174-178
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Tetradecanoylphorbol Acetate	136-139	vitronectin	Rattus norvegicus	78-89
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Tetradecanoylphorbol Acetate	136-139	vitronectin	Rattus norvegicus	203-214
2601266-8	1989	Combined treatment with A23187 and TPA could mimic both the initial and sustained effect of Ang II in the presence of extracellular Ca, though either one of them failed to do so when used alone.	Tetradecanoylphorbol Acetate	35-38	angiotensinogen	Rattus norvegicus	92-98
2482456-6	1989	By contrast, the stimulations of the PRL gene expression induced by TRH or by the phorbol ester TPA were not abolished by the calcium channel antagonist PN 200-110 whereas treatments combining TRH or TPA with BAY K8644 revealed the absence of any additive effect.	Tetradecanoylphorbol Acetate	200-203	prolactin	Rattus norvegicus	37-40
2560804-2	1989	Preincubation of the cells for 6 h with 100 nM TPA at 37 C resulted in a 90% decrease in total PKC activity.	Tetradecanoylphorbol Acetate	47-50	proline rich transmembrane protein 2	Homo sapiens	95-98
2482456-7	1989	Altogether these observations suggest that TRH, and TPA, might activate pathway(s) interacting with those triggered by the Ca2+ channel agonist for regulating PRL gene transcription but they do not support the hypothesis of a necessary implication of DHP-sensitive calcium channels in the regulation of PRL gene transcription by TRH.	Tetradecanoylphorbol Acetate	52-55	prolactin	Rattus norvegicus	159-162
2560804-7	1989	After incubation of the cells with VP for 15 min or [3H] phorbol-12-myristate-13-acetate (PMA) for 30 min, PKC activity in cytosol was decreased by 40% and 89%, respectively, while the activity in the membrane was increased by 138% and 405%, respectively.	Tetradecanoylphorbol Acetate	57-88	proline rich transmembrane protein 2	Homo sapiens	107-110
2560804-7	1989	After incubation of the cells with VP for 15 min or [3H] phorbol-12-myristate-13-acetate (PMA) for 30 min, PKC activity in cytosol was decreased by 40% and 89%, respectively, while the activity in the membrane was increased by 138% and 405%, respectively.	Tetradecanoylphorbol Acetate	90-93	proline rich transmembrane protein 2	Homo sapiens	107-110
2513808-7	1989	First the PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated monocytic-cell adhesion to EC at a dose consistent with stimulation of PKC (half-maximal response at 1-3 nM) and with a time course similar to that for thrombin stimulation (maximal by 4 h).	Tetradecanoylphorbol Acetate	24-55	coagulation factor II, thrombin	Homo sapiens	225-233
2633045-1	1989	Membranes were isolated from B cells stimulated with phorbol 12-myristate 13-acetate (PMA) for a time sufficient to allow maximal redistribution and activation of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	86-89	proline rich transmembrane protein 2	Homo sapiens	163-179
2633045-1	1989	Membranes were isolated from B cells stimulated with phorbol 12-myristate 13-acetate (PMA) for a time sufficient to allow maximal redistribution and activation of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	86-89	proline rich transmembrane protein 2	Homo sapiens	181-184
2633045-1	1989	Membranes were isolated from B cells stimulated with phorbol 12-myristate 13-acetate (PMA) for a time sufficient to allow maximal redistribution and activation of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	53-84	proline rich transmembrane protein 2	Homo sapiens	163-179
2633045-1	1989	Membranes were isolated from B cells stimulated with phorbol 12-myristate 13-acetate (PMA) for a time sufficient to allow maximal redistribution and activation of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	53-84	proline rich transmembrane protein 2	Homo sapiens	181-184
2557635-3	1989	IRF-1 mRNA induction was also demonstrated in cells treated with calcium ionophore A23187 or with phorbol 12-myristate 13-acetate, but not with epidermal growth factor, dibutyryl-cAMP, or the adenylate cyclase activator forskolin.	Tetradecanoylphorbol Acetate	98-129	interferon regulatory factor 1	Homo sapiens	0-5
2557829-2	1989	The stimulation of O2.- generation by phorbol 12-myristate 13-acetate (PMA) in human neutrophil-derived cytoplasts was inhibited by a variety of phospholipase A2 inhibitors in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	38-69	phospholipase A2 group IB	Homo sapiens	145-161
2513808-7	1989	First the PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated monocytic-cell adhesion to EC at a dose consistent with stimulation of PKC (half-maximal response at 1-3 nM) and with a time course similar to that for thrombin stimulation (maximal by 4 h).	Tetradecanoylphorbol Acetate	57-60	coagulation factor II, thrombin	Homo sapiens	225-233
2557829-2	1989	The stimulation of O2.- generation by phorbol 12-myristate 13-acetate (PMA) in human neutrophil-derived cytoplasts was inhibited by a variety of phospholipase A2 inhibitors in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	71-74	phospholipase A2 group IB	Homo sapiens	145-161
2808430-1	1989	Two distinct regions of the transforming growth factor-beta 1 (TGF-beta 1) promoter are responsive to autoregulation and activation by phorbol ester (12-O-tetradecanoylphorbol-13-acetate): sequences located between nucleotides -454 to -323 (first promoter) and between the two transcriptional start sites.	Tetradecanoylphorbol Acetate	150-186	transforming growth factor beta 1	Homo sapiens	28-61
2553811-6	1989	In vitro activation of bone marrow neutrophils with PMA or leukotriene B4 results in a dose dependent increase in Mac-1 and decrease in MEL-14 Ag expression within 1 h after treatment, thus reflecting what is found during inflammation in vivo.	Tetradecanoylphorbol Acetate	52-55	integrin subunit beta 2	Homo sapiens	114-132
2690823-1	1989	The tumour-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) induces insulin secretion from isolated pancreatic islets, and this suggests a potential role for protein kinase C in the regulation of stimulus-secretion coupling in islets.	Tetradecanoylphorbol Acetate	35-71	insulin	Homo sapiens	86-93
2808430-1	1989	Two distinct regions of the transforming growth factor-beta 1 (TGF-beta 1) promoter are responsive to autoregulation and activation by phorbol ester (12-O-tetradecanoylphorbol-13-acetate): sequences located between nucleotides -454 to -323 (first promoter) and between the two transcriptional start sites.	Tetradecanoylphorbol Acetate	150-186	transforming growth factor beta 1	Homo sapiens	63-73
2690823-1	1989	The tumour-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) induces insulin secretion from isolated pancreatic islets, and this suggests a potential role for protein kinase C in the regulation of stimulus-secretion coupling in islets.	Tetradecanoylphorbol Acetate	73-76	insulin	Homo sapiens	86-93
2690823-6	1989	Insulin secretion induced by TPA was completely suppressed (IC50 approximately 10 nM) by staurosporine, a potent protein kinase C inhibitor.	Tetradecanoylphorbol Acetate	29-32	insulin	Homo sapiens	0-7
2551660-7	1989	Protein kinase-C (PKC) was implicated in the inhibitory effects of PMA on both binding and adenylate cyclase activation, since inhibition was reduced by simultaneous incubation with the PKC inhibitors H7 and H8.	Tetradecanoylphorbol Acetate	67-70	proline rich transmembrane protein 2	Homo sapiens	0-16
2516715-4	1989	The three types of interferons and TPA differed in their absolute TAA-augmenting ability, even in single-cell subclones derived from MCF-7 cells and previously shown to display a differential susceptibility to IFN-alpha augmentation of B1.1 expression.	Tetradecanoylphorbol Acetate	35-38	interferon alpha 1	Homo sapiens	210-219
2572284-4	1989	When the T cells were stimulated with phytohemagglutinin (PHA) and phorbol myristate acetate (PMA), defective interleukin-2 (IL-2) secretion was observed.	Tetradecanoylphorbol Acetate	67-92	interleukin 2	Homo sapiens	110-123
2572284-4	1989	When the T cells were stimulated with phytohemagglutinin (PHA) and phorbol myristate acetate (PMA), defective interleukin-2 (IL-2) secretion was observed.	Tetradecanoylphorbol Acetate	94-97	interleukin 2	Homo sapiens	110-123
2507204-0	1989	Interleukin 2, interleukin 2 receptor, and interferon-gamma synthesis and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans.	Tetradecanoylphorbol Acetate	93-118	interferon gamma	Homo sapiens	43-59
12412753-7	1989	Only minimal inhibition of phorbol myristate acetate induced TNF secretion was observed.	Tetradecanoylphorbol Acetate	27-52	tumor necrosis factor	Homo sapiens	61-64
2478302-6	1989	The requirement for TcR crosslinking in triggering both secretion of granules and secretion of IFN from CTL was pharmacologically reproduced by the synergistic action of PMA, a protein kinase C activator, and the Ca2+ ionophore A23187.	Tetradecanoylphorbol Acetate	170-173	interferon alpha 1	Homo sapiens	95-98
2551660-7	1989	Protein kinase-C (PKC) was implicated in the inhibitory effects of PMA on both binding and adenylate cyclase activation, since inhibition was reduced by simultaneous incubation with the PKC inhibitors H7 and H8.	Tetradecanoylphorbol Acetate	67-70	proline rich transmembrane protein 2	Homo sapiens	18-21
2551660-7	1989	Protein kinase-C (PKC) was implicated in the inhibitory effects of PMA on both binding and adenylate cyclase activation, since inhibition was reduced by simultaneous incubation with the PKC inhibitors H7 and H8.	Tetradecanoylphorbol Acetate	67-70	proline rich transmembrane protein 2	Homo sapiens	186-189
2625810-3	1989	We also tested the effect of lipopolysaccharide (LPS), phorbol 12-myristate 13-acetate (PMA), zymosan and albumin-anti albumin complex (alb-anti alb) on production of Fn and PGE2 from AM.	Tetradecanoylphorbol Acetate	55-86	fibronectin 1	Homo sapiens	167-169
2531721-3	1989	TPA reduces the level of expression of CD20, CD21, mIg and CD45RA and increases CD45RO binding, thereby minimizing the phenotypic heterogeneity of the CLL clones and causing them to converge towards one end of the natural range.	Tetradecanoylphorbol Acetate	0-3	keratin 20	Homo sapiens	39-43
2531721-3	1989	TPA reduces the level of expression of CD20, CD21, mIg and CD45RA and increases CD45RO binding, thereby minimizing the phenotypic heterogeneity of the CLL clones and causing them to converge towards one end of the natural range.	Tetradecanoylphorbol Acetate	0-3	complement C3d receptor 2	Homo sapiens	45-49
2553815-0	1989	Generation of biologically active C-reactive protein peptides by a neutral protease on the membrane of phorbol myristate acetate-stimulated neutrophils.	Tetradecanoylphorbol Acetate	103-128	C-reactive protein	Homo sapiens	34-52
2625810-4	1989	LPS, PMA and zymosan suppressed Fn production but stimulated PGE2 production by AM from patients with IIP but indomethacin reversed the suppressive effect of LPS, PMA and zymosan on Fn production.	Tetradecanoylphorbol Acetate	5-8	fibronectin 1	Homo sapiens	32-34
2625810-4	1989	LPS, PMA and zymosan suppressed Fn production but stimulated PGE2 production by AM from patients with IIP but indomethacin reversed the suppressive effect of LPS, PMA and zymosan on Fn production.	Tetradecanoylphorbol Acetate	5-8	fibronectin 1	Homo sapiens	182-184
2517125-3	1989	The depressed IL-2 production by SLE T cells are largely reversed by the addition of either phorbol ester (PMA) or partially by a calcium ionophore.	Tetradecanoylphorbol Acetate	107-110	interleukin 2	Homo sapiens	14-18
2553815-2	1989	Maximum association of 125I-labeled CRP with neutrophils and 125I-labeled CRP degradation during association with these cells was achieved by stimulating the neutrophils with PMA at 10 ng/ml; a concentration in which azurophil granule release was not significant.	Tetradecanoylphorbol Acetate	175-178	C-reactive protein	Homo sapiens	36-39
2553815-2	1989	Maximum association of 125I-labeled CRP with neutrophils and 125I-labeled CRP degradation during association with these cells was achieved by stimulating the neutrophils with PMA at 10 ng/ml; a concentration in which azurophil granule release was not significant.	Tetradecanoylphorbol Acetate	175-178	C-reactive protein	Homo sapiens	74-77
2553815-8	1989	125I-labeled CRP degradation mediated by nonstimulated neutrophils, and neutrophil-conditioned medium (from both non-stimulated and PMA-stimulated cells) was inhibitable by alpha 1-antitrypsin and approximately seven times less at 1 h than that occurring during 125I-labeled CRP-association with PMA-stimulated neutrophils.	Tetradecanoylphorbol Acetate	132-135	C-reactive protein	Homo sapiens	13-16
2553815-8	1989	125I-labeled CRP degradation mediated by nonstimulated neutrophils, and neutrophil-conditioned medium (from both non-stimulated and PMA-stimulated cells) was inhibitable by alpha 1-antitrypsin and approximately seven times less at 1 h than that occurring during 125I-labeled CRP-association with PMA-stimulated neutrophils.	Tetradecanoylphorbol Acetate	132-135	serpin family A member 1	Homo sapiens	173-192
2553815-8	1989	125I-labeled CRP degradation mediated by nonstimulated neutrophils, and neutrophil-conditioned medium (from both non-stimulated and PMA-stimulated cells) was inhibitable by alpha 1-antitrypsin and approximately seven times less at 1 h than that occurring during 125I-labeled CRP-association with PMA-stimulated neutrophils.	Tetradecanoylphorbol Acetate	296-299	C-reactive protein	Homo sapiens	13-16
2553815-8	1989	125I-labeled CRP degradation mediated by nonstimulated neutrophils, and neutrophil-conditioned medium (from both non-stimulated and PMA-stimulated cells) was inhibitable by alpha 1-antitrypsin and approximately seven times less at 1 h than that occurring during 125I-labeled CRP-association with PMA-stimulated neutrophils.	Tetradecanoylphorbol Acetate	296-299	serpin family A member 1	Homo sapiens	173-192
2615195-8	1989	Phorbol ester (PMA) also stimulated elastase release but both PTH or PMA-induced elastase release was blunted by staurosporin, an inhibitor of protein kinase C. The 19-84 carboxyterminal PTH also produced significant stimulation of elastase release from PMNL but the amino-terminal 1-34 PTH or other peptide hormones (insulin, calcitonin, and ACTH) had no stimulatory effect on elastase release.	Tetradecanoylphorbol Acetate	69-72	proopiomelanocortin	Homo sapiens	343-347
2691880-12	1989	Finally, methimazole and phorbol 12-myristate 13-acetate show different effects on TSH-induced increases in thyroglobulin and thyroid peroxidase mRNA levels.	Tetradecanoylphorbol Acetate	25-56	thyroglobulin	Rattus norvegicus	108-121
2625810-4	1989	LPS, PMA and zymosan suppressed Fn production but stimulated PGE2 production by AM from patients with IIP but indomethacin reversed the suppressive effect of LPS, PMA and zymosan on Fn production.	Tetradecanoylphorbol Acetate	163-166	fibronectin 1	Homo sapiens	182-184
2531463-5	1989	We show that CD43 was rapidly superphosphorylated (within minutes) on serine residues following addition of phorbol ester (PMA) to peripheral blood lymphocytes.	Tetradecanoylphorbol Acetate	123-126	sialophorin	Homo sapiens	13-17
2813443-2	1989	The PKC activator 12-O-tetradeconylphorbol-13-acetate (TPA) at certain concentrations has been shown to potentiate the mitogenic effect of PRL, whereas at higher concentrations, TPA inhibits the PRL response.	Tetradecanoylphorbol Acetate	55-58	prolactin	Homo sapiens	139-142
2813443-2	1989	The PKC activator 12-O-tetradeconylphorbol-13-acetate (TPA) at certain concentrations has been shown to potentiate the mitogenic effect of PRL, whereas at higher concentrations, TPA inhibits the PRL response.	Tetradecanoylphorbol Acetate	55-58	prolactin	Homo sapiens	195-198
2813443-2	1989	The PKC activator 12-O-tetradeconylphorbol-13-acetate (TPA) at certain concentrations has been shown to potentiate the mitogenic effect of PRL, whereas at higher concentrations, TPA inhibits the PRL response.	Tetradecanoylphorbol Acetate	178-181	prolactin	Homo sapiens	139-142
2813443-2	1989	The PKC activator 12-O-tetradeconylphorbol-13-acetate (TPA) at certain concentrations has been shown to potentiate the mitogenic effect of PRL, whereas at higher concentrations, TPA inhibits the PRL response.	Tetradecanoylphorbol Acetate	178-181	prolactin	Homo sapiens	195-198
2818583-2	1989	Induction of the expressions of these IL-2R subunits was examined by the protein kinase-C (PK-C) activator (phorbol myristate acetate, PMA) and the calcium ionophore, ionomycine (IM).	Tetradecanoylphorbol Acetate	108-133	proline rich transmembrane protein 2	Homo sapiens	91-95
2813443-7	1989	On long-term exposure (3 days), high concentrations of TPA down-regulate the PKC enzyme; this down-regulation likely accounts for the inhibitory effect of high concentrations of TPA on the PRL stimulation of cell division.	Tetradecanoylphorbol Acetate	55-58	prolactin	Homo sapiens	189-192
2813443-7	1989	On long-term exposure (3 days), high concentrations of TPA down-regulate the PKC enzyme; this down-regulation likely accounts for the inhibitory effect of high concentrations of TPA on the PRL stimulation of cell division.	Tetradecanoylphorbol Acetate	178-181	prolactin	Homo sapiens	189-192
2777796-2	1989	We have demonstrated previously that cultured rat ovarian granulosa cells synthesize and secrete apoE, and this production of apoE is increased by agents that stimulate protein kinase A (cyclic AMP-dependent enzyme) (for example, cholera toxin) and protein kinase C (Ca2+/phospholipid-dependent enzyme) (for example, 12-O-tetradecanoylphorbol-13-acetate, a phorbol ester).	Tetradecanoylphorbol Acetate	317-353	apolipoprotein E	Rattus norvegicus	126-130
2790191-3	1989	Incubation with the differentiating agent phorbol-12-myristate-13-acetate markedly increased the percentage of cells with the CD4- CD8+ phenotype, suggesting that leukemic cells were already committed towards a differentiated element with the CD4- CD8+ phenotype.	Tetradecanoylphorbol Acetate	42-73	CD4 molecule	Homo sapiens	126-129
2790191-3	1989	Incubation with the differentiating agent phorbol-12-myristate-13-acetate markedly increased the percentage of cells with the CD4- CD8+ phenotype, suggesting that leukemic cells were already committed towards a differentiated element with the CD4- CD8+ phenotype.	Tetradecanoylphorbol Acetate	42-73	CD4 molecule	Homo sapiens	243-246
2558942-0	1989	Induction of ornithine decarboxylase in the stomach mucosa of swine with NaCl or 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	81-117	ornithine decarboxylase 1	Sus scrofa	13-36
2515000-8	1989	Pretreatment with phorbol 12-myristate 13-acetate (PMA) inhibited the responses of Tg, FMLP and A23187.	Tetradecanoylphorbol Acetate	18-49	formyl peptide receptor 1	Homo sapiens	87-91
2515000-8	1989	Pretreatment with phorbol 12-myristate 13-acetate (PMA) inhibited the responses of Tg, FMLP and A23187.	Tetradecanoylphorbol Acetate	51-54	formyl peptide receptor 1	Homo sapiens	87-91
2791204-15	1989	As reported previously for single applications, prolonged TPA application caused a change in morphology and a considerable decrease in numbers of Thy-1+ epidermal dendritic cells.	Tetradecanoylphorbol Acetate	58-61	thymus cell antigen 1, theta	Mus musculus	146-151
2558942-1	1989	The effect of sodium chloride and 12-O-tetradecanoylphorbol-13-acetate on ornithine decarboxylase (ODC) activity in gastric mucosa of miniature swine was investigated as a model for gastric inflammation.	Tetradecanoylphorbol Acetate	34-70	ornithine decarboxylase 1	Sus scrofa	74-97
2558942-1	1989	The effect of sodium chloride and 12-O-tetradecanoylphorbol-13-acetate on ornithine decarboxylase (ODC) activity in gastric mucosa of miniature swine was investigated as a model for gastric inflammation.	Tetradecanoylphorbol Acetate	34-70	ornithine decarboxylase 1	Sus scrofa	99-102
2482322-1	1989	Human monocytic cell line THP-1 incubated with as little as 10 ng/ml of phorbol myristate acetate bound and metabolized 1-2 micrograms of Ac-LDL over a 5-h period.	Tetradecanoylphorbol Acetate	72-97	GLI family zinc finger 2	Homo sapiens	26-31
2697687-6	1989	In contrast to the rapid elimination of cell surface CD4 by exposure of HL-60 to phorbol myristate acetate (PMA), the maximal reduction of CD4 by 1,25(OH)2D3 was attained within 48 h after the beginning of the exposure.	Tetradecanoylphorbol Acetate	81-106	CD4 molecule	Homo sapiens	53-56
2697687-6	1989	In contrast to the rapid elimination of cell surface CD4 by exposure of HL-60 to phorbol myristate acetate (PMA), the maximal reduction of CD4 by 1,25(OH)2D3 was attained within 48 h after the beginning of the exposure.	Tetradecanoylphorbol Acetate	108-111	CD4 molecule	Homo sapiens	53-56
2551911-4	1989	Activation of PKC by bFGF or TPA is inhibited in cells made PKC-deficient by pretreatment with high concentrations of TPA.	Tetradecanoylphorbol Acetate	118-121	fibroblast growth factor 2	Bos taurus	21-25
2482208-1	1989	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated prolactin (PRL) release from the PRL producing human B-lymphoblastoid cell line IM-9-P3 within 30 min with an EC50 of 5 x 10(-9) M. Increased release was entirely attributable to a loss from intracellular PRL pools.	Tetradecanoylphorbol Acetate	18-54	prolactin	Homo sapiens	72-81
2507662-5	1989	Although untreated and IFN-gamma-treated RAW264.7 cells underwent a respiratory burst when exposed to a stimulant such as opsonized zymosan or phorbol myristate acetate (PMA), infection of such cells with R. prowazekii was not associated with a measurable respiratory burst, as determined by monitoring hydrogen peroxide (H2O2) production and hexose monophosphate shunt activity.	Tetradecanoylphorbol Acetate	143-168	interferon gamma	Mus musculus	23-32
2507662-5	1989	Although untreated and IFN-gamma-treated RAW264.7 cells underwent a respiratory burst when exposed to a stimulant such as opsonized zymosan or phorbol myristate acetate (PMA), infection of such cells with R. prowazekii was not associated with a measurable respiratory burst, as determined by monitoring hydrogen peroxide (H2O2) production and hexose monophosphate shunt activity.	Tetradecanoylphorbol Acetate	170-173	interferon gamma	Mus musculus	23-32
2554052-6	1989	After activation of SC-u-PA by plasmin, u-PA activity of the culture medium was found to increase in a time- and dose-dependent manner when cells were incubated with phorbol myristic acetate (PMA).	Tetradecanoylphorbol Acetate	192-195	plasminogen activator, urokinase	Sus scrofa	23-27
2554052-6	1989	After activation of SC-u-PA by plasmin, u-PA activity of the culture medium was found to increase in a time- and dose-dependent manner when cells were incubated with phorbol myristic acetate (PMA).	Tetradecanoylphorbol Acetate	192-195	plasminogen activator, urokinase	Sus scrofa	40-44
2554052-8	1989	Stimulation of u-PA synthesis by PMA was also observed in two different epithelial tubular cell lines.	Tetradecanoylphorbol Acetate	33-36	plasminogen activator, urokinase	Sus scrofa	15-19
2554052-10	1989	However, 8 bromo cyclic AMP which increased u-PA release by LLC-PK1 cells was found to inhibit u-PA release by PMA-stimulated glomerular epithelial cells and MDCK cells.	Tetradecanoylphorbol Acetate	111-114	plasminogen activator, urokinase	Sus scrofa	44-48
2554052-10	1989	However, 8 bromo cyclic AMP which increased u-PA release by LLC-PK1 cells was found to inhibit u-PA release by PMA-stimulated glomerular epithelial cells and MDCK cells.	Tetradecanoylphorbol Acetate	111-114	plasminogen activator, urokinase	Sus scrofa	95-99
2554052-11	1989	By Northern blot analysis we found that PMA induced an increase of u-PA mRNA level in glomerular epithelial cells and that cyclic AMP had an opposite effect.	Tetradecanoylphorbol Acetate	40-43	plasminogen activator, urokinase	Sus scrofa	67-71
2558300-8	1989	Similar glucocorticoid receptor sites and binding affinities were observed in T24-NIH-3T3 or TPA-treated NIH-3T3 cells compared to wild-type untreated cells.	Tetradecanoylphorbol Acetate	93-96	nuclear receptor subfamily 3, group C, member 1	Mus musculus	8-31
2482208-1	1989	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated prolactin (PRL) release from the PRL producing human B-lymphoblastoid cell line IM-9-P3 within 30 min with an EC50 of 5 x 10(-9) M. Increased release was entirely attributable to a loss from intracellular PRL pools.	Tetradecanoylphorbol Acetate	18-54	prolactin	Homo sapiens	83-86
2482208-1	1989	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated prolactin (PRL) release from the PRL producing human B-lymphoblastoid cell line IM-9-P3 within 30 min with an EC50 of 5 x 10(-9) M. Increased release was entirely attributable to a loss from intracellular PRL pools.	Tetradecanoylphorbol Acetate	18-54	prolactin	Homo sapiens	105-108
2482208-1	1989	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated prolactin (PRL) release from the PRL producing human B-lymphoblastoid cell line IM-9-P3 within 30 min with an EC50 of 5 x 10(-9) M. Increased release was entirely attributable to a loss from intracellular PRL pools.	Tetradecanoylphorbol Acetate	18-54	prolactin	Homo sapiens	105-108
2482208-1	1989	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated prolactin (PRL) release from the PRL producing human B-lymphoblastoid cell line IM-9-P3 within 30 min with an EC50 of 5 x 10(-9) M. Increased release was entirely attributable to a loss from intracellular PRL pools.	Tetradecanoylphorbol Acetate	56-59	prolactin	Homo sapiens	72-81
2482208-1	1989	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated prolactin (PRL) release from the PRL producing human B-lymphoblastoid cell line IM-9-P3 within 30 min with an EC50 of 5 x 10(-9) M. Increased release was entirely attributable to a loss from intracellular PRL pools.	Tetradecanoylphorbol Acetate	56-59	prolactin	Homo sapiens	83-86
2482208-1	1989	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated prolactin (PRL) release from the PRL producing human B-lymphoblastoid cell line IM-9-P3 within 30 min with an EC50 of 5 x 10(-9) M. Increased release was entirely attributable to a loss from intracellular PRL pools.	Tetradecanoylphorbol Acetate	56-59	prolactin	Homo sapiens	105-108
2482208-1	1989	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated prolactin (PRL) release from the PRL producing human B-lymphoblastoid cell line IM-9-P3 within 30 min with an EC50 of 5 x 10(-9) M. Increased release was entirely attributable to a loss from intracellular PRL pools.	Tetradecanoylphorbol Acetate	56-59	prolactin	Homo sapiens	105-108
2482208-3	1989	Prolonged exposure of the cells to 2 x 10(-7) M TPA, however, led to a maximal reduction of hPRL mRNA levels after 24 h and a subsequent recovery by 72 h. Secretory rates followed a corresponding kinetic.	Tetradecanoylphorbol Acetate	48-51	prolactin	Homo sapiens	92-96
2594016-11	1989	However, CD4+ and CD8+ T cells produced large amounts of IL-2 when stimulated with mitogen and a protein kinase C activator, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	125-150	CD4 molecule	Homo sapiens	9-12
2510289-5	1989	However, the production of IL-2 was severely decreased in patient cells after stimulation with A23187/PMA (median 3541 units), although it was higher than in PHA-stimulated control cells (median 354 units).	Tetradecanoylphorbol Acetate	102-105	interleukin 2	Homo sapiens	27-31
2594016-11	1989	However, CD4+ and CD8+ T cells produced large amounts of IL-2 when stimulated with mitogen and a protein kinase C activator, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	125-150	interleukin 2	Homo sapiens	57-61
2594016-11	1989	However, CD4+ and CD8+ T cells produced large amounts of IL-2 when stimulated with mitogen and a protein kinase C activator, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	152-155	CD4 molecule	Homo sapiens	9-12
2594016-11	1989	However, CD4+ and CD8+ T cells produced large amounts of IL-2 when stimulated with mitogen and a protein kinase C activator, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	152-155	interleukin 2	Homo sapiens	57-61
2670930-7	1989	Northern blot analysis in cultured endothelial cells from human umbilical veins shows that PPET-1 mRNA is in fact rapidly induced by the active phorbol ester 12-O-tetradecanoylphorbol 13-acetate within 10 min.	Tetradecanoylphorbol Acetate	158-194	endothelin 1	Homo sapiens	91-97
2790038-7	1989	Chronic exposure to TPA resulted in down-regulation of PKC enzyme activity in both cell lines, and a selective decrease in PKC-beta RNA transcripts in both cell types.	Tetradecanoylphorbol Acetate	20-23	protein kinase C alpha	Homo sapiens	55-58
2507324-4	1989	Similarly, using TNF-specific antibody reagents, TNF-secreting cells were detected and quantitated in cell populations obtained from normal lymphoid tissues, bone marrow and peripheral blood, following activation with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	218-243	tumor necrosis factor	Homo sapiens	49-52
2504306-8	1989	Low concentrations of PMA (0.1 ng/mL) induce t-PA antigen primarily and not the inhibitors.	Tetradecanoylphorbol Acetate	22-25	plasminogen activator, tissue type	Homo sapiens	45-49
2475257-3	1989	In the present study, we examined different anti-CD4 monoclonal antibodies (mAbs) for their ability to influence lymphocyte proliferation induced by phorbol 12-myristate, 13-acetate (PMA).	Tetradecanoylphorbol Acetate	183-186	CD4 molecule	Homo sapiens	49-52
2606902-1	1989	The human monocyte-like cell line, THP-1, differentiated into macrophage-like cells on the addition of a phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	120-157	GLI family zinc finger 2	Homo sapiens	35-40
2759035-10	1989	Phorbol myristate acetate (1.6 microM) stimulated secretion of PTH and chromogranin-A at 3.0 mM Ca2+, but not at 0.5 mM Ca2+.	Tetradecanoylphorbol Acetate	0-25	parathyroid hormone	Homo sapiens	63-66
2759035-10	1989	Phorbol myristate acetate (1.6 microM) stimulated secretion of PTH and chromogranin-A at 3.0 mM Ca2+, but not at 0.5 mM Ca2+.	Tetradecanoylphorbol Acetate	0-25	chromogranin A	Homo sapiens	71-85
2561968-3	1989	TPA also stimulates growth on fibronectin and collagen similar to that observed on laminin under control conditions.	Tetradecanoylphorbol Acetate	0-3	fibronectin 1	Homo sapiens	30-41
2510716-4	1989	After a 10 s pre-treatment with PMA (16 nM), dense-granule secretion induced by thrombin (0.2 unit/ml), GTP[S] (40 microM) and NaF (30 mM) was potentiated, resulting in a greater than additive response to agent plus PMA.	Tetradecanoylphorbol Acetate	32-35	coagulation factor II, thrombin	Homo sapiens	80-88
2510716-4	1989	After a 10 s pre-treatment with PMA (16 nM), dense-granule secretion induced by thrombin (0.2 unit/ml), GTP[S] (40 microM) and NaF (30 mM) was potentiated, resulting in a greater than additive response to agent plus PMA.	Tetradecanoylphorbol Acetate	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
2510716-4	1989	After a 10 s pre-treatment with PMA (16 nM), dense-granule secretion induced by thrombin (0.2 unit/ml), GTP[S] (40 microM) and NaF (30 mM) was potentiated, resulting in a greater than additive response to agent plus PMA.	Tetradecanoylphorbol Acetate	216-219	coagulation factor II, thrombin	Homo sapiens	80-88
2510716-4	1989	After a 10 s pre-treatment with PMA (16 nM), dense-granule secretion induced by thrombin (0.2 unit/ml), GTP[S] (40 microM) and NaF (30 mM) was potentiated, resulting in a greater than additive response to agent plus PMA.	Tetradecanoylphorbol Acetate	216-219	C-X-C motif chemokine ligand 8	Homo sapiens	127-130
2510716-7	1989	That secretion induced by these agents is a protein kinase C-dependent event was demonstrable by using staurosporine, a protein kinase C inhibitor which at concentrations of 1-10 nM inhibited (70-90%) PMA-induced as well as thrombin- and NaF-induced secretion and protein phosphorylation.	Tetradecanoylphorbol Acetate	201-204	coagulation factor II, thrombin	Homo sapiens	224-232
2510716-7	1989	That secretion induced by these agents is a protein kinase C-dependent event was demonstrable by using staurosporine, a protein kinase C inhibitor which at concentrations of 1-10 nM inhibited (70-90%) PMA-induced as well as thrombin- and NaF-induced secretion and protein phosphorylation.	Tetradecanoylphorbol Acetate	201-204	C-X-C motif chemokine ligand 8	Homo sapiens	238-241
2526813-2	1989	Treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) led to reduced binding of K562 to immobilized fibronectin (FN), although treated cells expressed 10-fold more cell surface FNR than untreated cells.	Tetradecanoylphorbol Acetate	15-51	fibronectin 1	Homo sapiens	104-115
2526813-2	1989	Treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) led to reduced binding of K562 to immobilized fibronectin (FN), although treated cells expressed 10-fold more cell surface FNR than untreated cells.	Tetradecanoylphorbol Acetate	53-56	fibronectin 1	Homo sapiens	104-115
2668292-3	1989	The expression of NEP on the surface of neutrophils is down-regulated by endocytosis which can be induced by phorbol 12-myristate 13-acetate (PMA) at 37 degrees C. The activity of the enzyme on the surface of intact cells decreases by 76% within 5 min.	Tetradecanoylphorbol Acetate	109-140	membrane metalloendopeptidase	Homo sapiens	18-21
2668292-3	1989	The expression of NEP on the surface of neutrophils is down-regulated by endocytosis which can be induced by phorbol 12-myristate 13-acetate (PMA) at 37 degrees C. The activity of the enzyme on the surface of intact cells decreases by 76% within 5 min.	Tetradecanoylphorbol Acetate	142-145	membrane metalloendopeptidase	Homo sapiens	18-21
2668292-9	1989	The disappearance of NEP activity after adding PMA was inhibited by various agents.	Tetradecanoylphorbol Acetate	47-50	membrane metalloendopeptidase	Homo sapiens	21-24
2510716-8	1989	In membranes from PMA-treated platelets, thrombin-stimulated GTPase activity was significantly enhanced compared with that in untreated membranes (59% versus 82% increase over basal activity).	Tetradecanoylphorbol Acetate	18-21	coagulation factor II, thrombin	Homo sapiens	41-49
2545785-5	1989	Ionomycin synergizes with PMA in enhancing the activation of PKC.	Tetradecanoylphorbol Acetate	26-29	proline rich transmembrane protein 2	Homo sapiens	61-64
2554890-2	1989	Short-term (10 min) pretreatment of SMC with 12-O-tetradecanoylphorbol 13-acetate (TPA; 100 nM) decreases the angiotensin II-induced InsP3 formation.	Tetradecanoylphorbol Acetate	45-81	angiotensinogen	Rattus norvegicus	110-124
2554890-2	1989	Short-term (10 min) pretreatment of SMC with 12-O-tetradecanoylphorbol 13-acetate (TPA; 100 nM) decreases the angiotensin II-induced InsP3 formation.	Tetradecanoylphorbol Acetate	83-86	angiotensinogen	Rattus norvegicus	110-124
2554890-7	1989	In parallel with this potentiation of angiotensin II-induced generation of InsP3 by TPA, a down-regulation of protein kinase C activity is observed.	Tetradecanoylphorbol Acetate	84-87	angiotensinogen	Rattus norvegicus	38-52
2568381-6	1989	Pretreatment of rabbits with anti-CD18 and anti-ICAM-1 but not anti-CD11a mAb inhibited by greater than 60% neutrophil migration into PMA-induced inflamed rabbit lungs.	Tetradecanoylphorbol Acetate	134-137	integrin subunit beta 2	Homo sapiens	34-38
2803236-7	1989	Almost the full insulin effect was mimicked by a combination of phorbol esters and IP-oligosaccharides (basal 7%, insulin 50%, IP-oligosaccharides 30%, TPA 23%, IP-oligosaccharides + TPA 45%).	Tetradecanoylphorbol Acetate	152-155	insulin	Homo sapiens	16-23
2803236-7	1989	Almost the full insulin effect was mimicked by a combination of phorbol esters and IP-oligosaccharides (basal 7%, insulin 50%, IP-oligosaccharides 30%, TPA 23%, IP-oligosaccharides + TPA 45%).	Tetradecanoylphorbol Acetate	183-186	insulin	Homo sapiens	16-23
2550242-5	1989	Furthermore, 5-lipoxygenase activity of 10,000 x g supernatants from normal neutrophils pretreated with PMA was equivalent to that of the controls.	Tetradecanoylphorbol Acetate	104-107	arachidonate 5-lipoxygenase	Homo sapiens	13-27
2551678-4	1989	Phorbol 12-myristate 13-acetate (PMA) enhances this phenomenon independently of rhodopsin phosphorylation.	Tetradecanoylphorbol Acetate	33-36	rhodopsin	Homo sapiens	80-89
2546742-7	1989	Binding of transferrin after a 24-h incubation was also increased by other mitogenic agents, (Bu)2cAMP, forskolin (FK), insulin, insulin-like growth factor-I (IGF-I), and the phorbol ester TPA.	Tetradecanoylphorbol Acetate	189-192	transferrin	Rattus norvegicus	11-22
2745978-8	1989	TPA treatment of IL-2-dependent PBL at the peak of their growth caused phosphorylation of about two-thirds of preexisting unphosphorylated prosolin within 1 h. This was accompanied by cessation of cell proliferation, as indicated by measurements of TdR incorporation.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Homo sapiens	17-21
2526179-4	1989	CD4+CD45R+ cells produced high levels of IL-2 mRNA when stimulated with either PMA together with calcium ionophore, or with PHA, but they expressed only trace quantities of mRNA for IL-4 or IFN-gamma.	Tetradecanoylphorbol Acetate	79-82	CD4 molecule	Homo sapiens	0-3
2526179-4	1989	CD4+CD45R+ cells produced high levels of IL-2 mRNA when stimulated with either PMA together with calcium ionophore, or with PHA, but they expressed only trace quantities of mRNA for IL-4 or IFN-gamma.	Tetradecanoylphorbol Acetate	79-82	interleukin 2	Homo sapiens	41-45
2751660-3	1989	Exposure to 10 nM TPA resulted in a time-dependent increase in EGF-R mRNA, first apparent at 3 h and maximal between 9 and 24 h. There was a concomitant fall in ER mRNA with a maximum decline to 15-20% of control between 12 and 24 h. Although EGF-R mRNA levels declined between 24 and 72 h, both EGF-R mRNA and EGF-R binding remained above control levels and this was accompanied by a sustained depression of ER mRNA.	Tetradecanoylphorbol Acetate	18-21	epidermal growth factor receptor	Homo sapiens	63-68
2545906-0	1989	Induction of anti-EBNA-1 protein by 12-O-tetradecanoylphorbol-13-acetate treatment of human lymphoblastoid cells.	Tetradecanoylphorbol Acetate	36-72	EBNA-1	Human gammaherpesvirus 4	18-24
2472451-3	1989	FK506 inhibited IL-2 mRNA accumulation in Con A, Con A plus PMA, Ionomycin plus PMA, anti-CD3, and anti-CD3 plus PMA activated T cells.	Tetradecanoylphorbol Acetate	60-63	interleukin 2	Homo sapiens	16-20
2751660-3	1989	Exposure to 10 nM TPA resulted in a time-dependent increase in EGF-R mRNA, first apparent at 3 h and maximal between 9 and 24 h. There was a concomitant fall in ER mRNA with a maximum decline to 15-20% of control between 12 and 24 h. Although EGF-R mRNA levels declined between 24 and 72 h, both EGF-R mRNA and EGF-R binding remained above control levels and this was accompanied by a sustained depression of ER mRNA.	Tetradecanoylphorbol Acetate	18-21	estrogen receptor 1	Homo sapiens	161-163
2751660-3	1989	Exposure to 10 nM TPA resulted in a time-dependent increase in EGF-R mRNA, first apparent at 3 h and maximal between 9 and 24 h. There was a concomitant fall in ER mRNA with a maximum decline to 15-20% of control between 12 and 24 h. Although EGF-R mRNA levels declined between 24 and 72 h, both EGF-R mRNA and EGF-R binding remained above control levels and this was accompanied by a sustained depression of ER mRNA.	Tetradecanoylphorbol Acetate	18-21	epidermal growth factor receptor	Homo sapiens	243-248
2751660-3	1989	Exposure to 10 nM TPA resulted in a time-dependent increase in EGF-R mRNA, first apparent at 3 h and maximal between 9 and 24 h. There was a concomitant fall in ER mRNA with a maximum decline to 15-20% of control between 12 and 24 h. Although EGF-R mRNA levels declined between 24 and 72 h, both EGF-R mRNA and EGF-R binding remained above control levels and this was accompanied by a sustained depression of ER mRNA.	Tetradecanoylphorbol Acetate	18-21	epidermal growth factor receptor	Homo sapiens	243-248
2751660-3	1989	Exposure to 10 nM TPA resulted in a time-dependent increase in EGF-R mRNA, first apparent at 3 h and maximal between 9 and 24 h. There was a concomitant fall in ER mRNA with a maximum decline to 15-20% of control between 12 and 24 h. Although EGF-R mRNA levels declined between 24 and 72 h, both EGF-R mRNA and EGF-R binding remained above control levels and this was accompanied by a sustained depression of ER mRNA.	Tetradecanoylphorbol Acetate	18-21	epidermal growth factor receptor	Homo sapiens	243-248
2751660-3	1989	Exposure to 10 nM TPA resulted in a time-dependent increase in EGF-R mRNA, first apparent at 3 h and maximal between 9 and 24 h. There was a concomitant fall in ER mRNA with a maximum decline to 15-20% of control between 12 and 24 h. Although EGF-R mRNA levels declined between 24 and 72 h, both EGF-R mRNA and EGF-R binding remained above control levels and this was accompanied by a sustained depression of ER mRNA.	Tetradecanoylphorbol Acetate	18-21	estrogen receptor 1	Homo sapiens	409-411
2803911-2	1989	PKC activities were assayed in MOLT-3 and its five subclones resistant to TPA-induced cell differentiation.	Tetradecanoylphorbol Acetate	74-77	proline rich transmembrane protein 2	Homo sapiens	0-3
2502025-11	1989	Based on data with TPA and ionomycin, both protein kinase C and an as yet unidentified Ca2+-dependent protein kinase(s) appear to be activated upon stimulation with cholinergic agonists and CCK.	Tetradecanoylphorbol Acetate	19-22	cholecystokinin	Homo sapiens	190-193
2665839-9	1989	On the other hand, PMA inhibited growth of CMK cells and induced most of them to express the GPIIb/IIIa antigen.	Tetradecanoylphorbol Acetate	19-22	C-X-C motif chemokine ligand 9	Homo sapiens	43-46
2665839-10	1989	Furthermore, PMA induced CMK cells to produce growth activity toward new inocula of CMK cells.	Tetradecanoylphorbol Acetate	13-16	C-X-C motif chemokine ligand 9	Homo sapiens	25-28
2665839-10	1989	Furthermore, PMA induced CMK cells to produce growth activity toward new inocula of CMK cells.	Tetradecanoylphorbol Acetate	13-16	C-X-C motif chemokine ligand 9	Homo sapiens	84-87
2546831-0	1989	Effects of pretreatment with tetradecanoyl phorbol acetate on regulation of growth hormone and prolactin secretion from ovine anterior pituitary cells.	Tetradecanoylphorbol Acetate	29-58	growth hormone 1	Homo sapiens	76-90
2546831-0	1989	Effects of pretreatment with tetradecanoyl phorbol acetate on regulation of growth hormone and prolactin secretion from ovine anterior pituitary cells.	Tetradecanoylphorbol Acetate	29-58	prolactin	Homo sapiens	95-104
2546831-1	1989	Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells.	Tetradecanoylphorbol Acetate	0-29	growth hormone 1	Homo sapiens	47-61
2546831-1	1989	Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells.	Tetradecanoylphorbol Acetate	0-29	growth hormone 1	Homo sapiens	63-65
2546831-1	1989	Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells.	Tetradecanoylphorbol Acetate	0-29	prolactin	Homo sapiens	71-80
2803911-3	1989	The cytosolic PKC activities of TPA-resistant subclones were 36-53% of that of the parental MOLT-3 cells.	Tetradecanoylphorbol Acetate	32-35	proline rich transmembrane protein 2	Homo sapiens	14-17
2546831-1	1989	Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells.	Tetradecanoylphorbol Acetate	31-34	growth hormone 1	Homo sapiens	47-61
2803911-4	1989	TPA treatment led to a rapid decrease in PKC activities in the cytosol, together with a concomitant increase in PKC activities in the particulate fraction, in both MOLT-3 and a TPA-resistant subclone.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	41-44
2546831-1	1989	Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells.	Tetradecanoylphorbol Acetate	31-34	growth hormone 1	Homo sapiens	63-65
2803911-4	1989	TPA treatment led to a rapid decrease in PKC activities in the cytosol, together with a concomitant increase in PKC activities in the particulate fraction, in both MOLT-3 and a TPA-resistant subclone.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	112-115
2546831-1	1989	Tetradecanoyl phorbol acetate (TPA) stimulates growth hormone (GH) and prolactin secretion from ovine anterior pituitary cells.	Tetradecanoylphorbol Acetate	31-34	prolactin	Homo sapiens	71-80
2546831-2	1989	Pretreatment of the cells with TPA abolishes this effect, presumably due to down-regulation of protein kinase C. Such pretreatment did not alter effects of thyrotropin-releasing hormone or dopamine on prolactin secretion, suggesting no involvement of protein kinase C. Pretreatment with TPA attenuated actions of GH-releasing hormone on GH release (but not actions on cyclic AMP levels), possibly due to depletion of cellular stores of GH.	Tetradecanoylphorbol Acetate	31-34	growth hormone 1	Homo sapiens	313-315
2803911-5	1989	Thus, translocation of PKC from the cytosol to the membrane occurred following treatment with TPA, in both cell lines.	Tetradecanoylphorbol Acetate	94-97	proline rich transmembrane protein 2	Homo sapiens	23-26
2803911-6	1989	However, the amount of PKC translocated from the cytosol to particulate fraction for 60 min in a TPA-resistant subclone was about 20% of that of the parental MOLT-3 cells.	Tetradecanoylphorbol Acetate	97-100	proline rich transmembrane protein 2	Homo sapiens	23-26
2544300-11	1989	However, IL-6 did "prime" PMN, enhancing superoxide secretion by fMLP (10(-7) M)-treated PMN by 50.8% (5.9 +/- 1.0 to 8.9 +/- 1.5 nmol superoxide at 100 U of IL-6; P less than 0.01) and PMA (5.0 nM) by 54.3% (8.1 +/- 2.6 to 12.5 +/- 3.6 nmol; P less than 0.05).	Tetradecanoylphorbol Acetate	186-189	interleukin 6	Homo sapiens	9-13
2544300-11	1989	However, IL-6 did "prime" PMN, enhancing superoxide secretion by fMLP (10(-7) M)-treated PMN by 50.8% (5.9 +/- 1.0 to 8.9 +/- 1.5 nmol superoxide at 100 U of IL-6; P less than 0.01) and PMA (5.0 nM) by 54.3% (8.1 +/- 2.6 to 12.5 +/- 3.6 nmol; P less than 0.05).	Tetradecanoylphorbol Acetate	186-189	formyl peptide receptor 1	Homo sapiens	65-69
2803911-7	1989	These findings suggest that the quantity of cytosolic PKC activity and the extent of translocation may relate to responses to TPA-induced cell differentiation in this T-cell line.	Tetradecanoylphorbol Acetate	126-129	proline rich transmembrane protein 2	Homo sapiens	54-57
2500450-7	1989	Upon TPA induction, the secretion of u-PA polypeptides increased severalfold, and there was a transient accumulation of pro-u-PA in the culture medium.	Tetradecanoylphorbol Acetate	5-8	plasminogen activator, urokinase	Homo sapiens	124-128
2788092-2	1989	Here we show that IL4 and phorbol 12-myristate 13-acetate (PMA) induce, on a per cell basis, very high IgE secretion in purified human B cells by using a mouse thymoma (EL4) co-culture method.	Tetradecanoylphorbol Acetate	26-57	immunoglobulin heavy constant epsilon	Homo sapiens	103-106
2788092-2	1989	Here we show that IL4 and phorbol 12-myristate 13-acetate (PMA) induce, on a per cell basis, very high IgE secretion in purified human B cells by using a mouse thymoma (EL4) co-culture method.	Tetradecanoylphorbol Acetate	59-62	immunoglobulin heavy constant epsilon	Homo sapiens	103-106
2500450-7	1989	Upon TPA induction, the secretion of u-PA polypeptides increased severalfold, and there was a transient accumulation of pro-u-PA in the culture medium.	Tetradecanoylphorbol Acetate	5-8	plasminogen activator, urokinase	Homo sapiens	37-41
2528680-1	1989	The turnover of the colony-stimulating factor 1 receptor (CSF-1R), the c-fms proto-oncogene product, is accelerated by ligand binding or by activators of protein kinase C (PKC), such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	204-240	proline rich transmembrane protein 2	Homo sapiens	154-170
2543699-5	1989	Stimulation of cells by optimal amounts of calcium ionophore and PMA induced IL-2 mRNA that was completely suppressed by cyclosporine.	Tetradecanoylphorbol Acetate	65-68	interleukin 2	Homo sapiens	77-81
2543699-6	1989	The addition of anti-CD28 to T cells stimulated with PMA plus calcium ionophore induced a 5- to 100-fold increase in IL-2 gene expression and secretion that was resistant to cyclosporine.	Tetradecanoylphorbol Acetate	53-56	interleukin 2	Homo sapiens	117-121
2543699-7	1989	The CD28 signal was able to increase steady state IL-2 mRNA levels even in cells treated with maximally tolerated amounts of calcium ionophore and PMA.	Tetradecanoylphorbol Acetate	147-150	interleukin 2	Homo sapiens	50-54
2543699-9	1989	The signal provided by CD28 is distinct from that of CD3 because although anti-CD28 plus PMA-induced proliferation is resistant to cyclosporine, anti-CD3 or anti-CD3 plus PMA-induced IL-2 expression is sensitive.	Tetradecanoylphorbol Acetate	89-92	interleukin 2	Homo sapiens	183-187
2777908-0	1989	A phorbol ester and phospholipid-activated, calcium-unresponsive protein kinase in mouse epidermis: characterization and separation from protein kinase C. The phosphorylation of an Mr 82,000 protein (p82) in the Triton X-100 extract of the particulate fraction of mouse epidermis is dependent on the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) or diacylglycerol and phospholipid and, contrary to protein kinase C (PKC)-catalyzed phosphorylation, cannot be activated by calcium plus phospholipid.	Tetradecanoylphorbol Acetate	314-350	A kinase (PRKA) anchor protein 4	Mus musculus	200-203
2777908-0	1989	A phorbol ester and phospholipid-activated, calcium-unresponsive protein kinase in mouse epidermis: characterization and separation from protein kinase C. The phosphorylation of an Mr 82,000 protein (p82) in the Triton X-100 extract of the particulate fraction of mouse epidermis is dependent on the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) or diacylglycerol and phospholipid and, contrary to protein kinase C (PKC)-catalyzed phosphorylation, cannot be activated by calcium plus phospholipid.	Tetradecanoylphorbol Acetate	352-355	A kinase (PRKA) anchor protein 4	Mus musculus	200-203
2777910-3	1989	Concomitantly phospholipase A2, the enzyme liberating the prostaglandin precursor arachidonic acid, was inhibited by dexamethasone in TPA-differentiated but not in undifferentiated U937 cells.	Tetradecanoylphorbol Acetate	134-137	phospholipase A2 group IB	Homo sapiens	14-30
2504935-4	1989	In contrast, of the three effectors studied, only TPA induced transcription of the proto-oncogene c-fos, studied as a control gene responsive to various stimuli, and induced a rapid increase in urokinase-type PA (u-PA).	Tetradecanoylphorbol Acetate	50-53	plasminogen activator, urokinase	Homo sapiens	194-211
2504935-4	1989	In contrast, of the three effectors studied, only TPA induced transcription of the proto-oncogene c-fos, studied as a control gene responsive to various stimuli, and induced a rapid increase in urokinase-type PA (u-PA).	Tetradecanoylphorbol Acetate	50-53	plasminogen activator, urokinase	Homo sapiens	213-217
2504935-5	1989	Most of the u-PA activity induced by TPA remained cell-associated.	Tetradecanoylphorbol Acetate	37-40	plasminogen activator, urokinase	Homo sapiens	12-16
2528680-1	1989	The turnover of the colony-stimulating factor 1 receptor (CSF-1R), the c-fms proto-oncogene product, is accelerated by ligand binding or by activators of protein kinase C (PKC), such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	204-240	proline rich transmembrane protein 2	Homo sapiens	172-175
2528680-1	1989	The turnover of the colony-stimulating factor 1 receptor (CSF-1R), the c-fms proto-oncogene product, is accelerated by ligand binding or by activators of protein kinase C (PKC), such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	242-245	proline rich transmembrane protein 2	Homo sapiens	154-170
2528680-1	1989	The turnover of the colony-stimulating factor 1 receptor (CSF-1R), the c-fms proto-oncogene product, is accelerated by ligand binding or by activators of protein kinase C (PKC), such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	242-245	proline rich transmembrane protein 2	Homo sapiens	172-175
2542298-3	1989	Treatment of these cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) for 24 h decreased expression of NEP mRNA transcripts and decreased the biosynthetically labeled immunoprecipitable NEP antigen.	Tetradecanoylphorbol Acetate	30-66	neprilysin	Oryctolagus cuniculus	106-109
2480687-3	1989	The battery of PKC inhibitors used inhibited the antiviral effect induced by TPA.	Tetradecanoylphorbol Acetate	77-80	proline rich transmembrane protein 2	Homo sapiens	15-18
2480687-5	1989	These results suggest that PKC, possibly activated by interferon-receptor interaction, is not essential for inducing the antiviral effect of interferon, but, probably, mediates the antiviral effect of TPA.	Tetradecanoylphorbol Acetate	201-204	proline rich transmembrane protein 2	Homo sapiens	27-30
2742577-1	1989	While histamine or thrombin induced desensitization of inositol phosphate production is homologous TPA induced desensitization is heterologous.	Tetradecanoylphorbol Acetate	99-102	coagulation factor II, thrombin	Homo sapiens	19-27
2470752-5	1989	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) also stimulated phosphorylation of the same peptides from the EGF receptor as PDGF, and, in addition, induced phosphorylation of threonine 654.	Tetradecanoylphorbol Acetate	19-55	epidermal growth factor receptor	Homo sapiens	124-136
2470752-5	1989	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) also stimulated phosphorylation of the same peptides from the EGF receptor as PDGF, and, in addition, induced phosphorylation of threonine 654.	Tetradecanoylphorbol Acetate	57-60	epidermal growth factor receptor	Homo sapiens	124-136
2470752-9	1989	These data suggest that regulation of EGF receptor function by PDGF and TPA are distinct in these cells, even though some elements of regulation are shared.	Tetradecanoylphorbol Acetate	72-75	epidermal growth factor receptor	Homo sapiens	38-50
2480687-2	1989	The tumor promoter 12-o-tetradecanoyl-phorbol-13-acetate (TPA) (200 nM), known as activator of PKC induced an antiviral state when tested on human embryo fibroblasts challenged with the vesicular stomatitis virus.	Tetradecanoylphorbol Acetate	19-56	proline rich transmembrane protein 2	Homo sapiens	95-98
2480687-2	1989	The tumor promoter 12-o-tetradecanoyl-phorbol-13-acetate (TPA) (200 nM), known as activator of PKC induced an antiviral state when tested on human embryo fibroblasts challenged with the vesicular stomatitis virus.	Tetradecanoylphorbol Acetate	58-61	proline rich transmembrane protein 2	Homo sapiens	95-98
2764913-5	1989	In contrast, 12-O-tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C, significantly enhanced the incorporation of radioactivity into chromogranin A.	Tetradecanoylphorbol Acetate	13-49	chromogranin A	Bos taurus	154-168
2764913-5	1989	In contrast, 12-O-tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C, significantly enhanced the incorporation of radioactivity into chromogranin A.	Tetradecanoylphorbol Acetate	51-54	chromogranin A	Bos taurus	154-168
2764913-6	1989	Sphingosine, an inhibitor of protein kinase C, abolished both nicotine-stimulated and TPA-induced chromogranin A synthesis.	Tetradecanoylphorbol Acetate	86-89	chromogranin A	Bos taurus	98-112
2764913-7	1989	In addition, long-term treatment of chromaffin cells with TPA decreased protein kinase C activity and inhibited the nicotine-stimulated chromogranin A synthesis.	Tetradecanoylphorbol Acetate	58-61	chromogranin A	Bos taurus	136-150
2544450-1	1989	Treatment of human amniotic cells (UAC) with human interferon-alpha (Hu-IFN alpha) or phorbol myristate acetate (PMA) resulted in translocation of protein kinase C (PK-C) activity from the cytosol fraction to that of the membranes.	Tetradecanoylphorbol Acetate	86-111	proline rich transmembrane protein 2	Homo sapiens	147-163
2544450-1	1989	Treatment of human amniotic cells (UAC) with human interferon-alpha (Hu-IFN alpha) or phorbol myristate acetate (PMA) resulted in translocation of protein kinase C (PK-C) activity from the cytosol fraction to that of the membranes.	Tetradecanoylphorbol Acetate	86-111	proline rich transmembrane protein 2	Homo sapiens	165-169
2544450-1	1989	Treatment of human amniotic cells (UAC) with human interferon-alpha (Hu-IFN alpha) or phorbol myristate acetate (PMA) resulted in translocation of protein kinase C (PK-C) activity from the cytosol fraction to that of the membranes.	Tetradecanoylphorbol Acetate	113-116	proline rich transmembrane protein 2	Homo sapiens	147-163
2544450-1	1989	Treatment of human amniotic cells (UAC) with human interferon-alpha (Hu-IFN alpha) or phorbol myristate acetate (PMA) resulted in translocation of protein kinase C (PK-C) activity from the cytosol fraction to that of the membranes.	Tetradecanoylphorbol Acetate	113-116	proline rich transmembrane protein 2	Homo sapiens	165-169
2801310-3	1989	In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS.	Tetradecanoylphorbol Acetate	57-88	GLI family zinc finger 2	Homo sapiens	22-27
2801310-3	1989	In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS.	Tetradecanoylphorbol Acetate	57-88	interleukin 1 beta	Homo sapiens	155-164
2801310-3	1989	In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS.	Tetradecanoylphorbol Acetate	57-88	tumor necrosis factor	Homo sapiens	169-172
2801310-3	1989	In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS.	Tetradecanoylphorbol Acetate	90-93	GLI family zinc finger 2	Homo sapiens	22-27
2801310-3	1989	In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS.	Tetradecanoylphorbol Acetate	90-93	interleukin 1 beta	Homo sapiens	155-164
2801310-3	1989	In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS.	Tetradecanoylphorbol Acetate	90-93	tumor necrosis factor	Homo sapiens	169-172
2801336-3	1989	An activator of PKC, phorbol myristate acetate (PMA), alone did not influence the synthesis of the metalloproteinases to any great degree, but enhanced PGE2 production.	Tetradecanoylphorbol Acetate	21-46	proline rich transmembrane protein 2	Homo sapiens	16-19
2801336-3	1989	An activator of PKC, phorbol myristate acetate (PMA), alone did not influence the synthesis of the metalloproteinases to any great degree, but enhanced PGE2 production.	Tetradecanoylphorbol Acetate	48-51	proline rich transmembrane protein 2	Homo sapiens	16-19
2735424-10	1989	In contrast to complete blockade by 10(-8) PMA of the PGE2 (10(-5) M)-elicited Ca2+ transient, this concentration of PMA inhibited the Ca2+ transient evoked by 10(-9) M bradykinin (BK) by 50%.	Tetradecanoylphorbol Acetate	117-120	kininogen 1	Canis lupus familiaris	169-179
2735424-10	1989	In contrast to complete blockade by 10(-8) PMA of the PGE2 (10(-5) M)-elicited Ca2+ transient, this concentration of PMA inhibited the Ca2+ transient evoked by 10(-9) M bradykinin (BK) by 50%.	Tetradecanoylphorbol Acetate	117-120	kininogen 1	Canis lupus familiaris	181-183
2735424-11	1989	In fact 10(-4) M PMA only partially blocked the BK-elicited Ca2+ transient.	Tetradecanoylphorbol Acetate	17-20	kininogen 1	Canis lupus familiaris	48-50
2472158-6	1989	In MO, IFN-gamma stimulated the OB when co-stimulated with zymosan or PMA.	Tetradecanoylphorbol Acetate	70-73	interferon gamma	Homo sapiens	7-16
2527057-7	1989	Treatment of CMK cells with phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) greatly enhanced the reactivity with anti-platelet antibodies, increased the number of cells in which cytoplasm was dissociated into numerous segments and suppressed the reactivity with anti-glycophorin A.	Tetradecanoylphorbol Acetate	42-78	C-X-C motif chemokine ligand 9	Homo sapiens	13-16
2527057-7	1989	Treatment of CMK cells with phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) greatly enhanced the reactivity with anti-platelet antibodies, increased the number of cells in which cytoplasm was dissociated into numerous segments and suppressed the reactivity with anti-glycophorin A.	Tetradecanoylphorbol Acetate	42-78	glycophorin A (MNS blood group)	Homo sapiens	276-289
2527057-7	1989	Treatment of CMK cells with phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) greatly enhanced the reactivity with anti-platelet antibodies, increased the number of cells in which cytoplasm was dissociated into numerous segments and suppressed the reactivity with anti-glycophorin A.	Tetradecanoylphorbol Acetate	80-83	C-X-C motif chemokine ligand 9	Homo sapiens	13-16
2527057-7	1989	Treatment of CMK cells with phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) greatly enhanced the reactivity with anti-platelet antibodies, increased the number of cells in which cytoplasm was dissociated into numerous segments and suppressed the reactivity with anti-glycophorin A.	Tetradecanoylphorbol Acetate	80-83	glycophorin A (MNS blood group)	Homo sapiens	276-289
2568572-2	1989	Tyrosine hydroxylase (TH) immunoreactivity was measured in this cell line following treatment with retinoic acid (1-10 microM), 12-O-tetradecanoyl-phorbol-13-acetate (TPA; 16-160 nM), or combinations of these agents.	Tetradecanoylphorbol Acetate	128-165	tyrosine hydroxylase	Homo sapiens	0-20
2785869-0	1989	Induction of interleukin-1 and tumor necrosis factor by 12-O-tetradecanoylphorbol-13-acetate in phorbol ester-sensitive (SENCAR) and resistant (B6C3F1) mice.	Tetradecanoylphorbol Acetate	56-92	tumor necrosis factor	Mus musculus	31-52
2785869-6	1989	The findings reported herein indicated that topical application of TPA primed splenic MPs from both SENCAR and B6C3F1 mice in a quantitatively similar manner for the production of IL-1 and TNF; in addition, the release of IL-1 and TNF by splenic MPs from control (naive or acetone-dosed) SENCAR and B6C3F1 mice in response to LPS-triggering in vitro was not significantly different.	Tetradecanoylphorbol Acetate	67-70	tumor necrosis factor	Mus musculus	189-192
2785869-6	1989	The findings reported herein indicated that topical application of TPA primed splenic MPs from both SENCAR and B6C3F1 mice in a quantitatively similar manner for the production of IL-1 and TNF; in addition, the release of IL-1 and TNF by splenic MPs from control (naive or acetone-dosed) SENCAR and B6C3F1 mice in response to LPS-triggering in vitro was not significantly different.	Tetradecanoylphorbol Acetate	67-70	tumor necrosis factor	Mus musculus	231-234
2500449-5	1989	Tumor necrosis factor alpha (TNF alpha) and activators of protein kinase C including 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin induced the accumulation of IL-1 beta mRNA in human fibroblasts (WI-38).	Tetradecanoylphorbol Acetate	85-121	interleukin 1 beta	Homo sapiens	171-180
2500449-5	1989	Tumor necrosis factor alpha (TNF alpha) and activators of protein kinase C including 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin induced the accumulation of IL-1 beta mRNA in human fibroblasts (WI-38).	Tetradecanoylphorbol Acetate	123-126	tumor necrosis factor	Homo sapiens	0-27
2500449-5	1989	Tumor necrosis factor alpha (TNF alpha) and activators of protein kinase C including 12-O-tetradecanoylphorbol-13-acetate (TPA) and teleocidin induced the accumulation of IL-1 beta mRNA in human fibroblasts (WI-38).	Tetradecanoylphorbol Acetate	123-126	interleukin 1 beta	Homo sapiens	171-180
2500449-8	1989	Stability of IL-1 beta mRNA in fibroblasts exposed to TPA was more than fourfold greater than after fibroblasts were exposed to either TNF alpha or cycloheximide.	Tetradecanoylphorbol Acetate	54-57	interleukin 1 beta	Homo sapiens	13-22
2737285-1	1989	Change in the level of CuZn-superoxide dismutase (SOD) mRNA was examined using a molecular probe during differentiation of human monocytic leukemia U937 cells or promyelotic leukemia HL-60 cells induced by either 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or dimethylsulfoxide (DMSO).	Tetradecanoylphorbol Acetate	213-250	superoxide dismutase 1	Homo sapiens	23-48
2737285-1	1989	Change in the level of CuZn-superoxide dismutase (SOD) mRNA was examined using a molecular probe during differentiation of human monocytic leukemia U937 cells or promyelotic leukemia HL-60 cells induced by either 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or dimethylsulfoxide (DMSO).	Tetradecanoylphorbol Acetate	213-250	superoxide dismutase 1	Homo sapiens	50-53
2737285-1	1989	Change in the level of CuZn-superoxide dismutase (SOD) mRNA was examined using a molecular probe during differentiation of human monocytic leukemia U937 cells or promyelotic leukemia HL-60 cells induced by either 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or dimethylsulfoxide (DMSO).	Tetradecanoylphorbol Acetate	252-255	superoxide dismutase 1	Homo sapiens	23-48
2737285-1	1989	Change in the level of CuZn-superoxide dismutase (SOD) mRNA was examined using a molecular probe during differentiation of human monocytic leukemia U937 cells or promyelotic leukemia HL-60 cells induced by either 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or dimethylsulfoxide (DMSO).	Tetradecanoylphorbol Acetate	252-255	superoxide dismutase 1	Homo sapiens	50-53
2737285-2	1989	CuZn-SOD mRNA levels were found to decrease during the course of differentiation, and this response is specific for differentiation, since the treatment of human B cell leukemia cells or normal diploid fibroblasts with TPA failed to have any effect on the level of CuZn-SOD mRNA.	Tetradecanoylphorbol Acetate	219-222	superoxide dismutase 1	Homo sapiens	5-8
2568572-2	1989	Tyrosine hydroxylase (TH) immunoreactivity was measured in this cell line following treatment with retinoic acid (1-10 microM), 12-O-tetradecanoyl-phorbol-13-acetate (TPA; 16-160 nM), or combinations of these agents.	Tetradecanoylphorbol Acetate	128-165	tyrosine hydroxylase	Homo sapiens	22-24
2568572-2	1989	Tyrosine hydroxylase (TH) immunoreactivity was measured in this cell line following treatment with retinoic acid (1-10 microM), 12-O-tetradecanoyl-phorbol-13-acetate (TPA; 16-160 nM), or combinations of these agents.	Tetradecanoylphorbol Acetate	167-170	tyrosine hydroxylase	Homo sapiens	0-20
2568572-2	1989	Tyrosine hydroxylase (TH) immunoreactivity was measured in this cell line following treatment with retinoic acid (1-10 microM), 12-O-tetradecanoyl-phorbol-13-acetate (TPA; 16-160 nM), or combinations of these agents.	Tetradecanoylphorbol Acetate	167-170	tyrosine hydroxylase	Homo sapiens	22-24
2568572-3	1989	After 21 days of treatment with either TPA or retinoic acid (RA), TH immunoreactivity was measured in this using densitometric scans of Western blots, was doubled relative to untreated or serum-deprived SMS-KCNR cultures.	Tetradecanoylphorbol Acetate	39-42	tyrosine hydroxylase	Homo sapiens	66-68
2655888-2	1989	Enhanced expression of c-sis mRNA was induced by phorbol ester (PMA) and diacylglycerol, each of which activates protein kinase C. c-sis mRNA was also induced by transforming growth factor beta (TGF-beta).	Tetradecanoylphorbol Acetate	64-67	transforming growth factor beta 1	Homo sapiens	162-193
2655888-2	1989	Enhanced expression of c-sis mRNA was induced by phorbol ester (PMA) and diacylglycerol, each of which activates protein kinase C. c-sis mRNA was also induced by transforming growth factor beta (TGF-beta).	Tetradecanoylphorbol Acetate	64-67	transforming growth factor beta 1	Homo sapiens	195-203
2542298-3	1989	Treatment of these cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) for 24 h decreased expression of NEP mRNA transcripts and decreased the biosynthetically labeled immunoprecipitable NEP antigen.	Tetradecanoylphorbol Acetate	30-66	neprilysin	Oryctolagus cuniculus	189-192
2542298-3	1989	Treatment of these cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) for 24 h decreased expression of NEP mRNA transcripts and decreased the biosynthetically labeled immunoprecipitable NEP antigen.	Tetradecanoylphorbol Acetate	68-71	neprilysin	Oryctolagus cuniculus	106-109
2542298-3	1989	Treatment of these cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) for 24 h decreased expression of NEP mRNA transcripts and decreased the biosynthetically labeled immunoprecipitable NEP antigen.	Tetradecanoylphorbol Acetate	68-71	neprilysin	Oryctolagus cuniculus	189-192
2542298-4	1989	In contrast to its effects on NEP, TPA treatment induced expression of the secreted metalloproteinase collagenase and the tissue inhibitor of metalloproteinases.	Tetradecanoylphorbol Acetate	35-38	neprilysin	Oryctolagus cuniculus	30-33
2498324-11	1989	Based on experiments with both [3H]alkyl-PC and alkyl-[32P]PC, it is concluded that alkyl-PA and alkyl-PEt formed in response to PMA, OAG, or A23187 are derived exclusively from PLD action on alkyl-PC.	Tetradecanoylphorbol Acetate	129-132	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	178-181
2786991-6	1989	12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of these cells resulted in a 6-fold increase in the level of TGF-alpha secreted into the conditioned medium.	Tetradecanoylphorbol Acetate	0-36	transforming growth factor alpha	Bos taurus	116-125
2786991-6	1989	12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of these cells resulted in a 6-fold increase in the level of TGF-alpha secreted into the conditioned medium.	Tetradecanoylphorbol Acetate	38-41	transforming growth factor alpha	Bos taurus	116-125
2786991-7	1989	TPA appears to stimulate TGF-alpha secretion at the level of gene transcription as TPA treatment also resulted in an increased accumulation of the TGF-alpha mRNA.	Tetradecanoylphorbol Acetate	0-3	transforming growth factor alpha	Bos taurus	25-34
2786991-7	1989	TPA appears to stimulate TGF-alpha secretion at the level of gene transcription as TPA treatment also resulted in an increased accumulation of the TGF-alpha mRNA.	Tetradecanoylphorbol Acetate	0-3	transforming growth factor alpha	Bos taurus	147-156
2786991-7	1989	TPA appears to stimulate TGF-alpha secretion at the level of gene transcription as TPA treatment also resulted in an increased accumulation of the TGF-alpha mRNA.	Tetradecanoylphorbol Acetate	83-86	transforming growth factor alpha	Bos taurus	25-34
2786991-7	1989	TPA appears to stimulate TGF-alpha secretion at the level of gene transcription as TPA treatment also resulted in an increased accumulation of the TGF-alpha mRNA.	Tetradecanoylphorbol Acetate	83-86	transforming growth factor alpha	Bos taurus	147-156
2786991-8	1989	The epidermal growth factor (EGF) receptor mRNA was examined in these cell cultures and it increased with TPA treatment in an analogous manner to the TGF-alpha mRNA.	Tetradecanoylphorbol Acetate	106-109	epidermal growth factor receptor	Bos taurus	4-42
2786991-9	1989	EGF treatment of the pituitary cells resulted in an increased level of TGF-alpha mRNA which followed the same time course as TPA, maximal stimulation occurred after 8 h of treatment.	Tetradecanoylphorbol Acetate	125-128	LOC521832	Bos taurus	0-3
2786991-9	1989	EGF treatment of the pituitary cells resulted in an increased level of TGF-alpha mRNA which followed the same time course as TPA, maximal stimulation occurred after 8 h of treatment.	Tetradecanoylphorbol Acetate	125-128	transforming growth factor alpha	Bos taurus	71-80
2730662-2	1989	After 24 hrs of 5 microM 12-0-tetradecanoyl phorbol-13-acetate (TPA) treatment, PKC-directed histone phosphorylation and acute TPA effects on glucose transport were lost, but PKC-dependent vinculin phosphorylation was still evident.	Tetradecanoylphorbol Acetate	64-67	proline rich transmembrane protein 2	Homo sapiens	80-83
2730662-5	1989	Our findings indicate that TPA "down-regulated" BC3H-1 myocytes contain immunoreactive and functionally active PKC.	Tetradecanoylphorbol Acetate	27-30	proline rich transmembrane protein 2	Homo sapiens	111-114
2469725-6	1989	Cross-linking class I MHC molecules on Jurkat cells induced a rise by [Ca2+]i and induced IL-2 production upon co-stimulation with PMA.	Tetradecanoylphorbol Acetate	131-134	interleukin 2	Homo sapiens	90-94
2765502-2	1989	Induction of LPL in THP-1 cells appears to be mediated by PKC since it was affected by both phorbol 12-myristate 13-acetate (PMA) and a diacylglycerol analogue.	Tetradecanoylphorbol Acetate	92-123	GLI family zinc finger 2	Homo sapiens	20-25
2765502-2	1989	Induction of LPL in THP-1 cells appears to be mediated by PKC since it was affected by both phorbol 12-myristate 13-acetate (PMA) and a diacylglycerol analogue.	Tetradecanoylphorbol Acetate	125-128	GLI family zinc finger 2	Homo sapiens	20-25
2498324-12	1989	Furthermore, subthreshold concentrations of PMA (0.5-2.0 nM) or OAG (1.0-25 microM) combined with subthreshold levels of A23187 (15-60 nM) induce the formation of alkyl-[32P]PA and alkyl-[32P]PEt, suggesting that receptor-mediated activation of PLD might involve cooperative interactions between Ca2+ and diglyceride.	Tetradecanoylphorbol Acetate	44-47	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	245-248
2785404-6	1989	However, upon stimulation of confluent endothelial cell monolayers with phorbol myristate acetate, endothelial cells predominantly secrete vWF at the lumenal surface.	Tetradecanoylphorbol Acetate	72-97	von Willebrand factor	Homo sapiens	139-142
2542091-2	1989	Significant enhancement of IFN gamma production by poly(I):poly(C) is observed in the presence of the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA, a protein kinase C (PKC) activator).	Tetradecanoylphorbol Acetate	117-153	interferon gamma	Homo sapiens	27-36
2542091-2	1989	Significant enhancement of IFN gamma production by poly(I):poly(C) is observed in the presence of the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA, a protein kinase C (PKC) activator).	Tetradecanoylphorbol Acetate	117-153	plasminogen activator, tissue type	Homo sapiens	155-158
2544432-1	1989	Monoclonal antibodies (mAb) against CD3 or CD28 in conjunction with the tumor promoter phorbol 12-myristate 13-acetate (PMA) induce interleukin 2 receptor (IL2R) expression, IL2 production and proliferation in resting T cells.	Tetradecanoylphorbol Acetate	87-118	interleukin 2	Homo sapiens	156-159
2525477-2	1989	In I83 cells activated by a 1-h pulse of 12-O-tetradecanoylphorbol 13-acetate, the BSF-MP6-dependent DNA synthesis was strongly enhanced by 50-100 U/ml of recombinant IL 4.	Tetradecanoylphorbol Acetate	41-77	interleukin 4	Homo sapiens	167-171
2544432-1	1989	Monoclonal antibodies (mAb) against CD3 or CD28 in conjunction with the tumor promoter phorbol 12-myristate 13-acetate (PMA) induce interleukin 2 receptor (IL2R) expression, IL2 production and proliferation in resting T cells.	Tetradecanoylphorbol Acetate	120-123	interleukin 2	Homo sapiens	156-159
2540250-2	1989	Both antibiotics selectively inhibited superoxide generation by neutrophils activated with the N-formylated leukotactic tripeptide FMLP, the calcium ionophore A23187 and the pharmacologic agent benoxaprofen, while the responses initiated by the tumor promotor PMA and opsonized zymosan were unaffected.	Tetradecanoylphorbol Acetate	260-263	formyl peptide receptor 1	Homo sapiens	131-135
2666557-5	1989	Chronic exposure to 12-0-tetradecanoylphorbol-13-acetate (TPA), which inhibits insulin release in the human fetal pancreas, caused an 85% drop in IGF-II production, which was reversed when TPA was removed.	Tetradecanoylphorbol Acetate	58-61	insulin	Homo sapiens	79-86
2470733-4	1989	For each agonist tested (histamine, thrombin, phorbol 12-myristate 13-acetate, and the calcium ionophore A23187) a dose-dependent redistribution of GMP-140 to the endothelial surface was observed which closely paralleled the dose-dependent secretion of vWF into the cell supernatant.	Tetradecanoylphorbol Acetate	46-77	von Willebrand factor	Homo sapiens	253-256
2708913-5	1989	Langerhans cells stimulated with phorbol myristate acetate (PMA) and lipopolysaccharide (LPS) release 4-5 U TNF-alpha/ml.	Tetradecanoylphorbol Acetate	33-58	tumor necrosis factor	Homo sapiens	108-117
2565932-3	1989	Although the latter cells strongly proliferate in response to phorbol myristate acetate (PMA) + ionomycin, DETC, when exposed to interleukin-1 (IL-1), interleukin-3 (IL-3), concanavalin A (ConA), PMA, and ionomycin used either alone or in combination, do not exhibit significant mitotic activity.	Tetradecanoylphorbol Acetate	89-92	interleukin 3	Mus musculus	151-164
2708913-5	1989	Langerhans cells stimulated with phorbol myristate acetate (PMA) and lipopolysaccharide (LPS) release 4-5 U TNF-alpha/ml.	Tetradecanoylphorbol Acetate	60-63	tumor necrosis factor	Homo sapiens	108-117
2501664-7	1989	This inhibitory effect of botulinum toxin type D on TNF secretion from LPS-treated monocytes was partially reversed by treatment with 12-O-tetradecanoylphorbol-13-acetate or introduction of guanosine 5"-[gamma-thio]triphosphate into these cells.	Tetradecanoylphorbol Acetate	134-170	tumor necrosis factor	Homo sapiens	52-55
2547045-1	1989	When a liver perfusion with nitro blue tetrazolium (NBT) and phorbol myristate acetate (PMA) was performed in carbon tetrachloride (CCl4)-intoxicated rats, formazan deposition was remarkable in macrophages in the necrotic areas of the liver, its intensity varying with the extent of injury.	Tetradecanoylphorbol Acetate	61-86	C-C motif chemokine ligand 4	Rattus norvegicus	132-136
2547045-3	1989	The formazan content after incubation with NBT and PMA was higher in macrophages isolated from CCl4-intoxicated liver than in those from normal liver, though their PMA-induced chemiluminescence did not differ.	Tetradecanoylphorbol Acetate	51-54	C-C motif chemokine ligand 4	Rattus norvegicus	95-99
2787167-6	1989	Higher concentrations of TPA, which partially or totally depleted protein kinase C levels in the cells (10(-9)-2 X 10(-5) M), had an inhibitory effect on IL-1 beta mRNA expression.	Tetradecanoylphorbol Acetate	25-28	interleukin 1 beta	Homo sapiens	154-163
2655581-8	1989	In the presence of 10 nM-PMA, the sensitivity of cultured smooth-muscle cells towards Ang II was increased, and maximal values of Ang II-induced prostacyclin production were enhanced by about 60%.	Tetradecanoylphorbol Acetate	25-28	angiotensinogen	Rattus norvegicus	86-92
2655581-8	1989	In the presence of 10 nM-PMA, the sensitivity of cultured smooth-muscle cells towards Ang II was increased, and maximal values of Ang II-induced prostacyclin production were enhanced by about 60%.	Tetradecanoylphorbol Acetate	25-28	angiotensinogen	Rattus norvegicus	130-136
2702640-5	1989	However, a reduction in levels of receptor message appears to contribute to the maintenance of diminished transferrin receptor activity in these 12-O-tetradecanoylphorbol-13-acetate-treated cells.	Tetradecanoylphorbol Acetate	145-181	transferrin	Homo sapiens	106-117
2495278-1	1989	In this study we report that pretreatment of human amniotic (WISH) cells with interferon gamma (IFN-gamma) in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in the down-modulation of epidermal growth factor (EGF) receptors with respect to both receptor number and affinity.	Tetradecanoylphorbol Acetate	126-162	interferon gamma	Homo sapiens	78-105
2495278-1	1989	In this study we report that pretreatment of human amniotic (WISH) cells with interferon gamma (IFN-gamma) in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in the down-modulation of epidermal growth factor (EGF) receptors with respect to both receptor number and affinity.	Tetradecanoylphorbol Acetate	164-167	interferon gamma	Homo sapiens	78-105
2495278-3	1989	Pretreatment with IFN-gamma for 24 h enhanced the TPA-induced inhibition of EGF binding whereas IFN-gamma alone had no effect on binding.	Tetradecanoylphorbol Acetate	50-53	interferon gamma	Homo sapiens	18-27
2787167-4	1989	Addition of TPA to serum-starved U937 cells induced the expression of the interleukin 1 beta (IL-1 beta) gene.	Tetradecanoylphorbol Acetate	12-15	interleukin 1 beta	Homo sapiens	74-92
2787167-4	1989	Addition of TPA to serum-starved U937 cells induced the expression of the interleukin 1 beta (IL-1 beta) gene.	Tetradecanoylphorbol Acetate	12-15	interleukin 1 beta	Homo sapiens	94-103
2785473-4	1989	Functionally, these T cell lines secreted IL-2 in response to stimulation with phytohemagglutinin (PHA) and phorbol 12-myristate 13-acetate (PMA) in combination, but not to PHA or PMA alone.	Tetradecanoylphorbol Acetate	108-139	interleukin 2	Homo sapiens	42-46
2501902-8	1989	These results suggest that (1) the placenta is the major source of the increased uPA antigen during pregnancy, (2) entire vascular system is involved in the increased tPA antigen during pregnancy, (3) a further increase in tPA after delivery is due to the release of this enzyme from the involuting uterus.	Tetradecanoylphorbol Acetate	223-226	plasminogen activator, urokinase	Homo sapiens	81-84
2647729-7	1989	Phorbol myristate acetate (PMA) treatment increased the rate of insulin-stimulated receptor externalization 1.7-fold.	Tetradecanoylphorbol Acetate	0-25	insulin	Homo sapiens	64-71
2647729-7	1989	Phorbol myristate acetate (PMA) treatment increased the rate of insulin-stimulated receptor externalization 1.7-fold.	Tetradecanoylphorbol Acetate	27-30	insulin	Homo sapiens	64-71
2495728-4	1989	GP70 appears to be discharged into the bladder lumen; this process is increased by phorbol myristate acetate, an agent known to induce granule exocytosis.	Tetradecanoylphorbol Acetate	83-108	embigin	Homo sapiens	0-4
2785473-4	1989	Functionally, these T cell lines secreted IL-2 in response to stimulation with phytohemagglutinin (PHA) and phorbol 12-myristate 13-acetate (PMA) in combination, but not to PHA or PMA alone.	Tetradecanoylphorbol Acetate	141-144	interleukin 2	Homo sapiens	42-46
2467707-2	1989	To model this in vitro, phorbol myristate acetate (PMA)-activated PMN were exposed to shear stress on cultured human umbilical vein endothelial cells (HUVECs) and on plastic dishes coated with bovine serum albumin (BSA).	Tetradecanoylphorbol Acetate	51-54	albumin	Homo sapiens	200-213
2708448-7	1989	Nifedipine, verapamil, TPA, and pertussis toxin pretreatment were without effect on AII-induced increases in [Ca2+]i. PDGF and AII both stimulated increases in total inositol phosphate accumulation, although the one-half maximal concentration (ED50) for alterations in [Ca2+]i and phosphoinisitide hydrolysis differed by a factor of 10 for PDGF (3 X 10(-10) M for Ca2+ vs. 2.5 X 10(-9) M for phosphoinositide hydrolysis), but they were essentially identical for AII (7.5 X 10(-9) M for Ca2+ vs. 5.0 X 10(-9) M for phosphoinositide hydrolysis).	Tetradecanoylphorbol Acetate	23-26	angiotensinogen	Homo sapiens	127-130
2708448-7	1989	Nifedipine, verapamil, TPA, and pertussis toxin pretreatment were without effect on AII-induced increases in [Ca2+]i. PDGF and AII both stimulated increases in total inositol phosphate accumulation, although the one-half maximal concentration (ED50) for alterations in [Ca2+]i and phosphoinisitide hydrolysis differed by a factor of 10 for PDGF (3 X 10(-10) M for Ca2+ vs. 2.5 X 10(-9) M for phosphoinositide hydrolysis), but they were essentially identical for AII (7.5 X 10(-9) M for Ca2+ vs. 5.0 X 10(-9) M for phosphoinositide hydrolysis).	Tetradecanoylphorbol Acetate	23-26	angiotensinogen	Homo sapiens	127-130
2469910-4	1989	Treatment of the TsF2 producing hybridoma with phorbol myristate acetate (PMA) causes an increase in the level of IL-2 receptor expression in this hybridoma and enhances the effects of IL-2 on the biosynthesis of TsF2.	Tetradecanoylphorbol Acetate	47-72	interleukin 2	Homo sapiens	114-118
2469910-4	1989	Treatment of the TsF2 producing hybridoma with phorbol myristate acetate (PMA) causes an increase in the level of IL-2 receptor expression in this hybridoma and enhances the effects of IL-2 on the biosynthesis of TsF2.	Tetradecanoylphorbol Acetate	74-77	interleukin 2	Homo sapiens	114-118
2725935-2	1989	TPA proved more sensitive as a tumour marker than CEA, since increased TPA was found in 76% of the cancer cases compared to 42% for CEA.	Tetradecanoylphorbol Acetate	0-3	CEA cell adhesion molecule 3	Homo sapiens	132-135
2471069-2	1989	These genes are called TIS genes (for TPA-inducible sequences).	Tetradecanoylphorbol Acetate	38-41	programmed cell death 4	Mus musculus	23-26
2471069-3	1989	Epidermal growth factor (EGF), fibroblast growth factor (FGF), and TPA activated TIS gene expression with similar induction kinetics.	Tetradecanoylphorbol Acetate	67-70	programmed cell death 4	Mus musculus	81-84
2471069-6	1989	The results indicate that (i) modulation of a TPA-responsive sodium-potassium-chloride transport system is not necessary for TIS gene induction either by TPA or by other mitogens and (ii) TIS gene induction is not sufficient to guarantee a proliferative response to mitogenic stimulation.	Tetradecanoylphorbol Acetate	46-49	programmed cell death 4	Mus musculus	188-191
2494664-5	1989	Although NF-kappa B binding can be stimulated by phorbol 12-myristate 13-acetate, tumor necrosis factor alpha acts through an independent mechanism, inducing NF-kappa B binding in HT-2 cells, which did not show increased binding in response to phorbol 12-myristate 13-acetate, and causing superinduction in Jurkat T-lymphoma cells.	Tetradecanoylphorbol Acetate	49-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	9-19
2494664-5	1989	Although NF-kappa B binding can be stimulated by phorbol 12-myristate 13-acetate, tumor necrosis factor alpha acts through an independent mechanism, inducing NF-kappa B binding in HT-2 cells, which did not show increased binding in response to phorbol 12-myristate 13-acetate, and causing superinduction in Jurkat T-lymphoma cells.	Tetradecanoylphorbol Acetate	244-275	tumor necrosis factor	Mus musculus	82-109
2538464-6	1989	When the Ca2+ transient was induced with 0.1 microM angiotensin II, the PMA pretreatment markedly suppressed it and reduced also the rate of 45Ca2+ efflux from cells slightly.	Tetradecanoylphorbol Acetate	72-75	angiotensinogen	Homo sapiens	52-66
2494171-4	1989	Both pertussis toxin and phorbol 12-myristate 13-acetate (PMA) inhibited the thrombin-induced increase in IP3 but neither agent affected the PDGF-induced increase in IP3.	Tetradecanoylphorbol Acetate	25-56	coagulation factor II, thrombin	Homo sapiens	77-85
2494171-4	1989	Both pertussis toxin and phorbol 12-myristate 13-acetate (PMA) inhibited the thrombin-induced increase in IP3 but neither agent affected the PDGF-induced increase in IP3.	Tetradecanoylphorbol Acetate	58-61	coagulation factor II, thrombin	Homo sapiens	77-85
2494171-8	1989	The synergism between GTP gamma S and thrombin was virtually eliminated by 10 min prior exposure to PMA (200 ng/ml).	Tetradecanoylphorbol Acetate	100-103	coagulation factor II, thrombin	Homo sapiens	38-46
2540997-2	1989	Treatment of M2R cells with PMA resulted in a significant loss of beta-MSH binding.	Tetradecanoylphorbol Acetate	28-31	proopiomelanocortin	Homo sapiens	66-74
2492991-9	1989	Examination of the two enzyme activities involved in arachidonate incorporation into phospholipids indicated that both arachidonoyl-coenzyme A (CoA) synthase and arachidonoyl-CoA lysophosphatide acyltransferase were inactivated following treatment with PMA or 1-oleoyl-2-acetyl glycerol.	Tetradecanoylphorbol Acetate	253-256	Coenzyme A synthase	Homo sapiens	119-157
2521857-2	1989	We now show that the MDA468 breast cancer cells express the mRNA for the EGF-like molecule, transforming growth factor-alpha (TGF-alpha), and demonstrate that TPA or EGF cause an accumulation of both EGF receptor and TGF-alpha mRNA.	Tetradecanoylphorbol Acetate	159-162	tumor necrosis factor	Homo sapiens	92-124
2521857-2	1989	We now show that the MDA468 breast cancer cells express the mRNA for the EGF-like molecule, transforming growth factor-alpha (TGF-alpha), and demonstrate that TPA or EGF cause an accumulation of both EGF receptor and TGF-alpha mRNA.	Tetradecanoylphorbol Acetate	159-162	epidermal growth factor receptor	Homo sapiens	200-212
2521857-3	1989	The levels of EGF receptor mRNA paralleled our earlier protein data, with peak accumulations of 2-3-fold with 10(-9) M EGF and 3-5-fold with 100 ng/ml TPA seen between 6 and 8 h. A 7-fold accumulation of TGF-alpha mRNA was seen following 4 h of treatment with TPA, and a 2-fold accumulation was seen after 8 h with EGF.	Tetradecanoylphorbol Acetate	151-154	epidermal growth factor receptor	Homo sapiens	14-26
2521857-3	1989	The levels of EGF receptor mRNA paralleled our earlier protein data, with peak accumulations of 2-3-fold with 10(-9) M EGF and 3-5-fold with 100 ng/ml TPA seen between 6 and 8 h. A 7-fold accumulation of TGF-alpha mRNA was seen following 4 h of treatment with TPA, and a 2-fold accumulation was seen after 8 h with EGF.	Tetradecanoylphorbol Acetate	260-263	epidermal growth factor receptor	Homo sapiens	14-26
2784064-5	1989	In the presence of the phorbol ester TPA, leukemic blasts from two cases differentiated along the B precursor pathway to the [CD2-CD10+CD19+CD20+C mu+slg-] pre-B cell stage.	Tetradecanoylphorbol Acetate	37-40	membrane metalloendopeptidase	Homo sapiens	130-134
2646943-8	1989	Measured either early or late after TPA addition, the phorbol ester reduced insulin binding by congruent to 40%.	Tetradecanoylphorbol Acetate	36-39	insulin	Homo sapiens	76-83
2784064-5	1989	In the presence of the phorbol ester TPA, leukemic blasts from two cases differentiated along the B precursor pathway to the [CD2-CD10+CD19+CD20+C mu+slg-] pre-B cell stage.	Tetradecanoylphorbol Acetate	37-40	keratin 20	Homo sapiens	140-144
2492903-1	1989	Recombinant DNA-derived murine gamma-interferon (rMuIFN-gamma) was tested in the murine skin multistage carcinogenesis model as a modulator of 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion.	Tetradecanoylphorbol Acetate	181-184	interferon gamma	Mus musculus	31-47
2492903-8	1989	Consequently, TPA functioned as a copromoter in those situations in which combined TPA and IFN-gamma treatments elevated papilloma multiplicities.	Tetradecanoylphorbol Acetate	14-17	interferon gamma	Mus musculus	91-100
2492903-1	1989	Recombinant DNA-derived murine gamma-interferon (rMuIFN-gamma) was tested in the murine skin multistage carcinogenesis model as a modulator of 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion.	Tetradecanoylphorbol Acetate	143-179	interferon gamma	Mus musculus	31-47
2783885-10	1989	Addition of culture supernatants from phytohemagglutinin- and phorbol myristate acetate-stimulated peripheral blood mononuclear cells to the "Tac-negative" TIL-induced detectable Tac expression within 48 h. These results indicate that both non-Tac and Tac IL-2 receptors play important roles during IL-2-dependent proliferation of TIL.	Tetradecanoylphorbol Acetate	62-87	interleukin 2	Homo sapiens	256-260
2493338-5	1989	The production of IL-2 in normal lymphocytes stimulated with A23187/PMA was 33 times higher than that after stimulation with PHA.	Tetradecanoylphorbol Acetate	68-71	interleukin 2	Homo sapiens	18-22
2493338-6	1989	In AIDS lymphocytes the production of IL-2 induced by all activators was severely decreased compared to control subjects, although the production of IL-2 after stimulation with A23187/PMA was higher than that in control lymphocytes after stimulation with PHA.	Tetradecanoylphorbol Acetate	184-187	interleukin 2	Homo sapiens	38-42
2493338-6	1989	In AIDS lymphocytes the production of IL-2 induced by all activators was severely decreased compared to control subjects, although the production of IL-2 after stimulation with A23187/PMA was higher than that in control lymphocytes after stimulation with PHA.	Tetradecanoylphorbol Acetate	184-187	interleukin 2	Homo sapiens	149-153
2783885-10	1989	Addition of culture supernatants from phytohemagglutinin- and phorbol myristate acetate-stimulated peripheral blood mononuclear cells to the "Tac-negative" TIL-induced detectable Tac expression within 48 h. These results indicate that both non-Tac and Tac IL-2 receptors play important roles during IL-2-dependent proliferation of TIL.	Tetradecanoylphorbol Acetate	62-87	interleukin 2	Homo sapiens	299-303
2498085-0	1989	The 5" flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.	Tetradecanoylphorbol Acetate	144-147	taste 2 receptor member 64 pseudogene	Homo sapiens	30-33
2496956-3	1989	We used the phorbol ester/lipopolysaccharide (PMA + LPS) co-induction of IL-1 mRNA and CD13 expression in U937 cells to demonstrate the specificity of the technique.	Tetradecanoylphorbol Acetate	46-49	interleukin 1 beta	Homo sapiens	73-77
2498085-2	1989	We show here that the level of MCF-7 cell pS2 mRNA can also be increased by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	96-132	taste 2 receptor member 64 pseudogene	Homo sapiens	42-45
2537172-3	1989	Incubation of ROS cells with PTH or phorbol 12-myristate 13-acetate (PMA) for 1-30 min caused a rapid and transient decrease in PKC activity in the cytosol, which was associated with a transient increase in PKC activity in the membrane fraction.	Tetradecanoylphorbol Acetate	69-72	parathyroid hormone	Rattus norvegicus	29-32
2498085-2	1989	We show here that the level of MCF-7 cell pS2 mRNA can also be increased by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	134-137	taste 2 receptor member 64 pseudogene	Homo sapiens	42-45
2537172-6	1989	The effects of PTH and PMA on PKC were dose dependent, with ED50 values of 0.3 nM PTH and 4 nM PMA.	Tetradecanoylphorbol Acetate	23-26	parathyroid hormone	Rattus norvegicus	82-85
2498085-3	1989	We further demonstrate, using transient transfection assays, that the -428 to -332 5" flanking sequence of the pS2 gene contains DNA enhancer elements responsive to oestrogens, TPA, EGF, the c-Ha-ras oncoprotein and the c-jun protein.	Tetradecanoylphorbol Acetate	177-180	taste 2 receptor member 64 pseudogene	Homo sapiens	111-114
2537172-6	1989	The effects of PTH and PMA on PKC were dose dependent, with ED50 values of 0.3 nM PTH and 4 nM PMA.	Tetradecanoylphorbol Acetate	95-98	parathyroid hormone	Rattus norvegicus	15-18
2784474-10	1989	Long-term incubation of HUVE with phorbol 12-myristate 13-acetate (PMA), a compound that causes release of HMW vWf from Weibel-Palade bodies in HUVE, resulted in a marked decrease in matrix vWf (0.2% to 1% of the total vWf).	Tetradecanoylphorbol Acetate	34-65	von Willebrand factor	Homo sapiens	111-114
2493458-16	1989	Similarly, TPA, which rapidly induces the translocation of vinculin and talin to ectopic sites in many types of immortalized cells, had no gross effect on the adhesion plaques of myosacs, primary fibroblastic cells, or presumptive myoblasts.	Tetradecanoylphorbol Acetate	11-14	vinculin	Gallus gallus	59-67
2538545-4	1989	PMA caused a 4.0-8.3-fold increase in the rate of ethanol metabolism and this increase was completely suppressed in the presence of SOD.	Tetradecanoylphorbol Acetate	0-3	superoxide dismutase 1	Homo sapiens	132-135
2784474-10	1989	Long-term incubation of HUVE with phorbol 12-myristate 13-acetate (PMA), a compound that causes release of HMW vWf from Weibel-Palade bodies in HUVE, resulted in a marked decrease in matrix vWf (0.2% to 1% of the total vWf).	Tetradecanoylphorbol Acetate	34-65	von Willebrand factor	Homo sapiens	190-193
2784474-10	1989	Long-term incubation of HUVE with phorbol 12-myristate 13-acetate (PMA), a compound that causes release of HMW vWf from Weibel-Palade bodies in HUVE, resulted in a marked decrease in matrix vWf (0.2% to 1% of the total vWf).	Tetradecanoylphorbol Acetate	34-65	von Willebrand factor	Homo sapiens	190-193
2784474-10	1989	Long-term incubation of HUVE with phorbol 12-myristate 13-acetate (PMA), a compound that causes release of HMW vWf from Weibel-Palade bodies in HUVE, resulted in a marked decrease in matrix vWf (0.2% to 1% of the total vWf).	Tetradecanoylphorbol Acetate	67-70	von Willebrand factor	Homo sapiens	111-114
2784474-10	1989	Long-term incubation of HUVE with phorbol 12-myristate 13-acetate (PMA), a compound that causes release of HMW vWf from Weibel-Palade bodies in HUVE, resulted in a marked decrease in matrix vWf (0.2% to 1% of the total vWf).	Tetradecanoylphorbol Acetate	67-70	von Willebrand factor	Homo sapiens	190-193
2784474-10	1989	Long-term incubation of HUVE with phorbol 12-myristate 13-acetate (PMA), a compound that causes release of HMW vWf from Weibel-Palade bodies in HUVE, resulted in a marked decrease in matrix vWf (0.2% to 1% of the total vWf).	Tetradecanoylphorbol Acetate	67-70	von Willebrand factor	Homo sapiens	190-193
2537976-1	1989	Human tumor necrosis factor alpha (TNF-alpha) gene expression can be induced primarily in cells of the monocyte/macrophage lineage by a variety of inducers, including lipopolysaccharide, phorbol esters such as phorbol 12-myristate 13-acetate, and virus or synthetic double-stranded RNA [poly(I).poly(C)].	Tetradecanoylphorbol Acetate	210-241	tumor necrosis factor	Homo sapiens	6-33
2537976-2	1989	In this paper we show that the TNF-alpha gene also responds to virus and phorbol 12-myristate 13-acetate in B lymphocytes and that virus is the most potent inducer of TNF-alpha mRNA in both monocyte and B-cell lines.	Tetradecanoylphorbol Acetate	73-104	tumor necrosis factor	Homo sapiens	31-40
2664475-6	1989	The pS2 mRNA, but not cathepsin-D mRNA, was also induced up to 8-fold by protein kinase-C activation with 12-O-tetradecanoylphorbol-13-acetate, suggesting the possible involvement of this transduction pathway in pS2 mRNA induction.	Tetradecanoylphorbol Acetate	106-142	taste 2 receptor member 64 pseudogene	Homo sapiens	4-7
2537976-1	1989	Human tumor necrosis factor alpha (TNF-alpha) gene expression can be induced primarily in cells of the monocyte/macrophage lineage by a variety of inducers, including lipopolysaccharide, phorbol esters such as phorbol 12-myristate 13-acetate, and virus or synthetic double-stranded RNA [poly(I).poly(C)].	Tetradecanoylphorbol Acetate	210-241	tumor necrosis factor	Homo sapiens	35-44
2785706-10	1989	Furthermore, CD43+ B cells are included in the population which responds to signals delivered by TPA, anti-CD43 or anti-CDw40 antibodies, and the proliferation of this population is not merely due to an expansion of the small population of CD43+ cells present among these cells.	Tetradecanoylphorbol Acetate	97-100	sialophorin	Homo sapiens	13-17
2521661-5	1989	The inhibitors which were effective on Ca2+ mobilization also inhibited IL-2 production initiated by an anti-CD3 mAb in the presence of 12-O-tetradecanoylphorbol-13-acetate, and to a lesser extent by PHA or the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	136-172	interleukin 2	Homo sapiens	72-76
2923875-3	1989	Association and dissociation events were sensitive to Ca2+ concentrations in the low micromolar range, and the Ca2+ sensitivity of both processes was increased when the membranes had been preincubated with the protein kinase C-activating phorbol ester, 4 beta-phorbol 12-myristate 13-acetate (TPA).	Tetradecanoylphorbol Acetate	253-291	plasminogen activator, tissue type	Homo sapiens	293-296
2785706-3	1989	In the presence of TPA or antibodies to CDw40, the proportions of CD43+ cells drastically increased.	Tetradecanoylphorbol Acetate	19-22	sialophorin	Homo sapiens	66-70
2785706-6	1989	Tonsillar populations depleted of CD43+ B cells responded with lower proliferation to TPA alone or to TPA and B1B6 or anti-CDw40 antibodies.	Tetradecanoylphorbol Acetate	86-89	sialophorin	Homo sapiens	34-38
2785706-6	1989	Tonsillar populations depleted of CD43+ B cells responded with lower proliferation to TPA alone or to TPA and B1B6 or anti-CDw40 antibodies.	Tetradecanoylphorbol Acetate	102-105	sialophorin	Homo sapiens	34-38
2785816-1	1989	The kinetics of interleukin 2 mRNA accumulation in the leukemic T-cell line Jurkat, which can be induced with phytohemagglutinin and phorbol 12-myristate 13-acetate to produce large amounts of interleukin 2, was analyzed by a modified DNA-excess solution hybridization assay using a 5"-32P-labeled oligodeoxyribonucleotide 30 bases long as probe.	Tetradecanoylphorbol Acetate	133-164	interleukin 2	Homo sapiens	16-29
2914906-0	1989	In situ phosphorylation of human platelet myosin heavy and light chains by protein kinase C. Treatment of human platelets with 162 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in phosphorylation of a number of peptides, including myosin heavy chain and the 20-kDa myosin light chain.	Tetradecanoylphorbol Acetate	134-170	myosin light chain 9	Homo sapiens	267-292
2643439-6	1989	Exposure of human umbilical vein endothelial cells to bradykinin, thrombin or interleukin-1 resulted in negligible release of either hexosaminidase or lactate dehydrogenase (LDH), in contrast to phorbol myristate acetate, which caused a parallel, dose-dependent release of both enzymes.	Tetradecanoylphorbol Acetate	195-220	kininogen 1	Homo sapiens	54-64
2643439-6	1989	Exposure of human umbilical vein endothelial cells to bradykinin, thrombin or interleukin-1 resulted in negligible release of either hexosaminidase or lactate dehydrogenase (LDH), in contrast to phorbol myristate acetate, which caused a parallel, dose-dependent release of both enzymes.	Tetradecanoylphorbol Acetate	195-220	coagulation factor II, thrombin	Homo sapiens	66-74
2643668-11	1989	An approximately ten-fold greater level of IL-4 production was observed when they were stimulated with A23187 in combination with PMA.	Tetradecanoylphorbol Acetate	130-133	interleukin 4	Homo sapiens	43-47
2914906-0	1989	In situ phosphorylation of human platelet myosin heavy and light chains by protein kinase C. Treatment of human platelets with 162 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in phosphorylation of a number of peptides, including myosin heavy chain and the 20-kDa myosin light chain.	Tetradecanoylphorbol Acetate	172-175	myosin light chain 9	Homo sapiens	267-292
2541080-1	1989	We have examined the effect of different monoclonal antibodies (MAb) to the CD11/CD18 family of surface antigens on the production of superoxide anion by phorbol myristate acetate (PMA)-differentiated U-937 cells upon stimulation with concanavalin A (Con A).	Tetradecanoylphorbol Acetate	154-179	integrin subunit beta 2	Homo sapiens	81-85
2467815-3	1989	IL 4 inhibits both the spontaneous and the phorbol myristate acetate (PMA)-induced hyperexpression of CD5 on tonsil B cells.	Tetradecanoylphorbol Acetate	43-68	interleukin 4	Homo sapiens	0-4
2467815-3	1989	IL 4 inhibits both the spontaneous and the phorbol myristate acetate (PMA)-induced hyperexpression of CD5 on tonsil B cells.	Tetradecanoylphorbol Acetate	70-73	interleukin 4	Homo sapiens	0-4
2467815-4	1989	In contrast, IL 4 only suppresses the PMA-induced hyperexpression of CD5 on B-CLL, whereas the spontaneous CD5 expression is essentially unaffected.	Tetradecanoylphorbol Acetate	38-41	interleukin 4	Homo sapiens	13-17
2644975-0	1989	Interleukin-3, GM-CSF, and TPA induce distinct phosphorylation events in an interleukin 3-dependent multipotential cell line.	Tetradecanoylphorbol Acetate	27-30	interleukin 3	Mus musculus	76-89
2644975-3	1989	In addition, sodium orthovanadate, an inhibitor of phosphotyrosine phosphatase, and 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a known activator of protein kinase C, also stimulated DNA synthesis in these cells, suggesting that protein phosphorylation might be involved in the mechanism of action of mIL-3 and mGM-CSF.	Tetradecanoylphorbol Acetate	84-121	interleukin 3	Mus musculus	302-307
2783393-2	1989	IL-4 induced marked proliferation of thymocytes after PHA and TPA stimulation, in contrast to the marginal response of T cells from adult peripheral blood.	Tetradecanoylphorbol Acetate	62-65	interleukin 4	Homo sapiens	0-4
2910505-8	1989	Finally, 48 hr stimulation of LGL with TPA (10(-6) g/ml), a treatment able to inactivate most of the PK-C cellular pool, almost completely abrogated NK activity.	Tetradecanoylphorbol Acetate	39-42	proline rich transmembrane protein 2	Homo sapiens	101-105
2541080-1	1989	We have examined the effect of different monoclonal antibodies (MAb) to the CD11/CD18 family of surface antigens on the production of superoxide anion by phorbol myristate acetate (PMA)-differentiated U-937 cells upon stimulation with concanavalin A (Con A).	Tetradecanoylphorbol Acetate	181-184	integrin subunit beta 2	Homo sapiens	81-85
2523864-1	1989	Recombinant IL-2 (rIL-2) and IL-4 (rIL-4) promote proliferation of human CD4+ T cells activated in the presence of PHA, TPA or OKT-3 monoclonal antibody (MAb), whereas the production of interferon-gamma (IFN) can be induced only by rIL-2.	Tetradecanoylphorbol Acetate	120-123	interleukin 2	Homo sapiens	12-16
2541249-1	1989	In these experiments, both calcium and 12-O-tetradecanoylphorbol 13-acetate (TPA) were necessary for maximal phosphorylation of MP26.	Tetradecanoylphorbol Acetate	39-75	major intrinsic protein of lens fiber	Homo sapiens	128-132
2541249-1	1989	In these experiments, both calcium and 12-O-tetradecanoylphorbol 13-acetate (TPA) were necessary for maximal phosphorylation of MP26.	Tetradecanoylphorbol Acetate	77-80	major intrinsic protein of lens fiber	Homo sapiens	128-132
2465548-3	1989	Surface IL-1R levels are less than 2000 receptors per cell in postconfluent cultures but increase 9- to 20-fold 24 hr after treatment with phorbol 12-myristate 13-acetate (PMA) at 10 ng/ml or after raising the extracellular Ca2+ concentration to 2 mM.	Tetradecanoylphorbol Acetate	139-170	interleukin 1 receptor type 1	Homo sapiens	8-13
2465548-3	1989	Surface IL-1R levels are less than 2000 receptors per cell in postconfluent cultures but increase 9- to 20-fold 24 hr after treatment with phorbol 12-myristate 13-acetate (PMA) at 10 ng/ml or after raising the extracellular Ca2+ concentration to 2 mM.	Tetradecanoylphorbol Acetate	172-175	interleukin 1 receptor type 1	Homo sapiens	8-13
2783435-6	1989	PMA could induce CD4 and CD8 phosphorylation in both CD3L and CD3H fractions.	Tetradecanoylphorbol Acetate	0-3	CD4 molecule	Homo sapiens	17-20
2536017-7	1989	Finally, incubation of HeLa cells in the presence of epidermal growth factor or phorbol 12-myristate 13-acetate results, over a period of 24 h, in a progressive change in uPA binding: an approximately 10-fold increase in the number of sites is accompanied by a 10-fold decrease in their affinity.	Tetradecanoylphorbol Acetate	80-111	plasminogen activator, urokinase	Homo sapiens	171-174
2536017-8	1989	Cross-linking and phase partitioning of 125I-uPA bound to epidermal growth factor- or phorbol 12-myristate 13-acetate-treated cells indicate that, as in control conditions, it is associated with a Mr 45,000 cell surface amphiphilic polypeptide.	Tetradecanoylphorbol Acetate	86-117	plasminogen activator, urokinase	Homo sapiens	45-48
2536028-6	1989	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (100 ng/ml), a protein kinase C stimulator, increases apoE accumulation in the medium 8-10-fold, while 4 alpha-phorbol 12,13-didecanoate, the inactive phorbol congener, has no such effect.	Tetradecanoylphorbol Acetate	18-54	apolipoprotein E	Rattus norvegicus	109-113
2536062-8	1989	Thus, PMA activates the NF kappa B sites through a PKC-dependent pathway while ligands to TCR/CD3 and CD28 activate the LTR through a cyclosporin A-sensitive, PKC-dependent pathway of T cell activation.	Tetradecanoylphorbol Acetate	6-9	nuclear factor kappa B subunit 1	Homo sapiens	24-34
2523864-1	1989	Recombinant IL-2 (rIL-2) and IL-4 (rIL-4) promote proliferation of human CD4+ T cells activated in the presence of PHA, TPA or OKT-3 monoclonal antibody (MAb), whereas the production of interferon-gamma (IFN) can be induced only by rIL-2.	Tetradecanoylphorbol Acetate	120-123	interleukin 4	Homo sapiens	29-33
2523864-1	1989	Recombinant IL-2 (rIL-2) and IL-4 (rIL-4) promote proliferation of human CD4+ T cells activated in the presence of PHA, TPA or OKT-3 monoclonal antibody (MAb), whereas the production of interferon-gamma (IFN) can be induced only by rIL-2.	Tetradecanoylphorbol Acetate	120-123	CD4 molecule	Homo sapiens	73-76
2545552-7	1989	In addition, phorbol myristate acetate (PMA) and normal neutrophils, but not O2 metabolite deficient neutrophils from patients with chronic granulomatous disease (CGD), caused DMTU disappearance in vitro which was decreased by simultaneous addition of catalase, but not SOD, sodium benzoate or DMSO.	Tetradecanoylphorbol Acetate	13-38	catalase	Homo sapiens	252-260
2912135-6	1989	We conclude that a rise in aequorin-indicated [Ca2+]i is necessary for PMA or DAG to activate platelets or to alter the subsequent platelet response to thrombin; this [Ca2+]i rise may be a prerequisite for activation of protein kinase C.	Tetradecanoylphorbol Acetate	71-74	coagulation factor II, thrombin	Homo sapiens	152-160
2462935-7	1989	In vitro studies of dual-fluorochrome-sorted, TPA-stimulated splenic B cells demonstrated significantly greater tritiated thymidine incorporation and Ig secretion by the CD20+ CD5- cells than by the CD20+ CD5+ subset.	Tetradecanoylphorbol Acetate	46-49	keratin 20	Homo sapiens	170-174
2642028-7	1989	In addition vanadate also induced IL-2 secretion in Jurkat cells when associated with the phorbol ester TPA, further demonstrating the importance of these phosphorylation reactions in the process of T cell activation.	Tetradecanoylphorbol Acetate	104-107	interleukin 2	Homo sapiens	34-38
2540955-4	1989	When the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or serum is added to cultures of U-1690 cells the Mr 66,000 polypeptide is rapidly enriched while the Mr 60,000 form is decreased in the L-myc immunoprecipitates.	Tetradecanoylphorbol Acetate	23-60	MYCL proto-oncogene, bHLH transcription factor	Homo sapiens	204-209
2540955-4	1989	When the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or serum is added to cultures of U-1690 cells the Mr 66,000 polypeptide is rapidly enriched while the Mr 60,000 form is decreased in the L-myc immunoprecipitates.	Tetradecanoylphorbol Acetate	62-65	MYCL proto-oncogene, bHLH transcription factor	Homo sapiens	204-209
2540955-5	1989	This effect is correlated with the ability of phorbol ester and diacylglycerol analogues to activate protein kinase C. The TPA-induced phosphorylation of the L-myc protein occurs in a protein synthesis-independent manner as it is not inhibited by cycloheximide or anisomycin.	Tetradecanoylphorbol Acetate	123-126	MYCL proto-oncogene, bHLH transcription factor	Homo sapiens	158-163
2540955-6	1989	These data indicate that the phosphorylation of the L-myc nuclear oncoprotein is modulated in response to TPA via a rapid signal transduction system involving protein kinase C. This mechanism could play an important role in the response of lung cells to e.g. bombesin-related growth factors.	Tetradecanoylphorbol Acetate	106-109	MYCL proto-oncogene, bHLH transcription factor	Homo sapiens	52-57
2522047-2	1989	It is shown here that eight alloreactive CD4+ T cell clones (TCC) secreted significant amounts of TNF-alpha after stimulation with either specific alloantigen or 12-O-tetradecanoylphorbol 13-acetate together with the calcium ionophore ionomycin (up to 50 ng/ml/24 h/10(6) cells) whereas CD8+ TCC failed to do so (max.	Tetradecanoylphorbol Acetate	162-198	tumor necrosis factor	Homo sapiens	98-107
2539864-9	1989	Thrombin-induced hydrolysis of PIP2 was inhibited by treatment of the membranes with pertussis toxin or pretreatment of intact platelets with 12-O-tetradecanoyl-13-acetate (TPA) prior to preparation of membranes.	Tetradecanoylphorbol Acetate	173-176	coagulation factor II, thrombin	Homo sapiens	0-8
2912135-1	1989	We found that the previous addition of PMA or DAG either enhanced or inhibited the platelet response if thrombin was subsequently added, depending on the latter"s concentration.	Tetradecanoylphorbol Acetate	39-42	coagulation factor II, thrombin	Homo sapiens	104-112
2912135-2	1989	The effects of PMA or DAG on the response to thrombin were obtained only if the agonists were added in concentrations sufficient to elevate [Ca2+]i themselves.	Tetradecanoylphorbol Acetate	15-18	coagulation factor II, thrombin	Homo sapiens	45-53
2462935-7	1989	In vitro studies of dual-fluorochrome-sorted, TPA-stimulated splenic B cells demonstrated significantly greater tritiated thymidine incorporation and Ig secretion by the CD20+ CD5- cells than by the CD20+ CD5+ subset.	Tetradecanoylphorbol Acetate	46-49	keratin 20	Homo sapiens	199-203
2639723-1	1989	Tumor necrosis factor-alpha and transforming growth factor-beta, like 12-O-tetradecanoylphorbol 13-acetate, induce differentiation of ML-1 human myeloblastic leukemia cells along the monocyte path.	Tetradecanoylphorbol Acetate	70-106	tumor necrosis factor	Homo sapiens	0-27
2561951-1	1989	Activation of protein kinase C (PKC) by phorbol esters (TPA) results in a modification of the cyclic AMP system leading to either attenuation or amplification of the cyclic AMP signal.	Tetradecanoylphorbol Acetate	56-59	proline rich transmembrane protein 2	Homo sapiens	14-30
2561951-1	1989	Activation of protein kinase C (PKC) by phorbol esters (TPA) results in a modification of the cyclic AMP system leading to either attenuation or amplification of the cyclic AMP signal.	Tetradecanoylphorbol Acetate	56-59	proline rich transmembrane protein 2	Homo sapiens	32-35
2561951-3	1989	The effect appeared to be mediated by PKC since diacylglycerols caused the same amplification as did TPA while inactive phorbol esters were without effect.	Tetradecanoylphorbol Acetate	101-104	proline rich transmembrane protein 2	Homo sapiens	38-41
2561951-5	1989	TPA also caused translocation of PKC; however, the time course of the translocation was longer than the time course of the enhancement of adenylate cyclase activity.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	33-36
2561951-6	1989	Thus, the ability of TPA to amplify cyclic AMP synthesis is probably mediated by activation of PKC that is already present in the membrane.	Tetradecanoylphorbol Acetate	21-24	proline rich transmembrane protein 2	Homo sapiens	95-98
2547602-0	1989	The insulin-like effects of phorbol myristate acetate (PMA) in the isolated fat cell.	Tetradecanoylphorbol Acetate	28-53	insulin	Homo sapiens	4-11
2547602-0	1989	The insulin-like effects of phorbol myristate acetate (PMA) in the isolated fat cell.	Tetradecanoylphorbol Acetate	55-58	insulin	Homo sapiens	4-11
2545552-7	1989	In addition, phorbol myristate acetate (PMA) and normal neutrophils, but not O2 metabolite deficient neutrophils from patients with chronic granulomatous disease (CGD), caused DMTU disappearance in vitro which was decreased by simultaneous addition of catalase, but not SOD, sodium benzoate or DMSO.	Tetradecanoylphorbol Acetate	13-38	superoxide dismutase 1	Homo sapiens	270-273
2545552-7	1989	In addition, phorbol myristate acetate (PMA) and normal neutrophils, but not O2 metabolite deficient neutrophils from patients with chronic granulomatous disease (CGD), caused DMTU disappearance in vitro which was decreased by simultaneous addition of catalase, but not SOD, sodium benzoate or DMSO.	Tetradecanoylphorbol Acetate	40-43	catalase	Homo sapiens	252-260
2545552-7	1989	In addition, phorbol myristate acetate (PMA) and normal neutrophils, but not O2 metabolite deficient neutrophils from patients with chronic granulomatous disease (CGD), caused DMTU disappearance in vitro which was decreased by simultaneous addition of catalase, but not SOD, sodium benzoate or DMSO.	Tetradecanoylphorbol Acetate	40-43	superoxide dismutase 1	Homo sapiens	270-273
2512251-2	1989	Treatment of CD4+ or CD8+ CTL clones with phorbol myristate acetate (PMA), phytohemagglutinin, or mitogenic combinations of CD2-specific antibodies also resulted in CD4 or CD8 phosphorylation.	Tetradecanoylphorbol Acetate	42-67	CD4 molecule	Homo sapiens	13-16
2478466-6	1989	First, the effects of cAMP on MBP phosphorylation are reversed with exogenous TPA; and second, cAMP inhibits the incorporation of 1-[14C]arachidonate into DAG and specifically inhibits the turnover (as judged by 32PO4 3-incorporation) of phosphatidylinositol.	Tetradecanoylphorbol Acetate	78-81	cathelicidin antimicrobial peptide	Homo sapiens	22-26
2512251-2	1989	Treatment of CD4+ or CD8+ CTL clones with phorbol myristate acetate (PMA), phytohemagglutinin, or mitogenic combinations of CD2-specific antibodies also resulted in CD4 or CD8 phosphorylation.	Tetradecanoylphorbol Acetate	42-67	CD4 molecule	Homo sapiens	165-168
2512251-2	1989	Treatment of CD4+ or CD8+ CTL clones with phorbol myristate acetate (PMA), phytohemagglutinin, or mitogenic combinations of CD2-specific antibodies also resulted in CD4 or CD8 phosphorylation.	Tetradecanoylphorbol Acetate	69-72	CD4 molecule	Homo sapiens	13-16
15493263-1	1989	Phorbol myristate acetage (PMA) and Ca2+ ionophore A23187 mimic early signal transduction pathways and activate purified human T cells to secrete large quantities of interleukin-2 (IL-2) and to proliferate.	Tetradecanoylphorbol Acetate	27-30	interleukin 2	Homo sapiens	166-179
15493263-1	1989	Phorbol myristate acetage (PMA) and Ca2+ ionophore A23187 mimic early signal transduction pathways and activate purified human T cells to secrete large quantities of interleukin-2 (IL-2) and to proliferate.	Tetradecanoylphorbol Acetate	27-30	interleukin 2	Homo sapiens	181-185
2512251-2	1989	Treatment of CD4+ or CD8+ CTL clones with phorbol myristate acetate (PMA), phytohemagglutinin, or mitogenic combinations of CD2-specific antibodies also resulted in CD4 or CD8 phosphorylation.	Tetradecanoylphorbol Acetate	69-72	CD4 molecule	Homo sapiens	165-168
2512251-5	1989	Exposure of these transfectants to PMA induced rapid phosphorylation of the CD4 and CD8 molecules.	Tetradecanoylphorbol Acetate	35-38	CD4 molecule	Homo sapiens	76-79
2512260-1	1989	The C57Bl/6-derived T cell line, L12-R4, produced murine interferon-gamma (IFN gamma) in response to mitogenic stimulation by phorbol myristate acetate (PMA) or concanavalin A (Con A), but not by staphylococcal enterotoxin A (SEA).	Tetradecanoylphorbol Acetate	126-151	interferon gamma	Mus musculus	57-73
2464751-3	1989	Spectrophotometric analyses of 560 corticotropes from fractions enriched to 90% by counterflow centrifugation showed a 30% increase in the average area of the dark blue label for biotinylated CRH after a 1-h exposure to 10 nM AVP or after activation of protein kinase-C [by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or L calcium channels (by Bay K 8644).	Tetradecanoylphorbol Acetate	274-311	arginine vasopressin	Homo sapiens	226-229
2512260-1	1989	The C57Bl/6-derived T cell line, L12-R4, produced murine interferon-gamma (IFN gamma) in response to mitogenic stimulation by phorbol myristate acetate (PMA) or concanavalin A (Con A), but not by staphylococcal enterotoxin A (SEA).	Tetradecanoylphorbol Acetate	126-151	interferon gamma	Mus musculus	75-84
2512260-1	1989	The C57Bl/6-derived T cell line, L12-R4, produced murine interferon-gamma (IFN gamma) in response to mitogenic stimulation by phorbol myristate acetate (PMA) or concanavalin A (Con A), but not by staphylococcal enterotoxin A (SEA).	Tetradecanoylphorbol Acetate	153-156	interferon gamma	Mus musculus	57-73
2512260-1	1989	The C57Bl/6-derived T cell line, L12-R4, produced murine interferon-gamma (IFN gamma) in response to mitogenic stimulation by phorbol myristate acetate (PMA) or concanavalin A (Con A), but not by staphylococcal enterotoxin A (SEA).	Tetradecanoylphorbol Acetate	153-156	interferon gamma	Mus musculus	75-84
2535858-6	1989	The IL-4 gene is inducible after treatment of human T cell clone by phorbol-12-myristate-13-acetate (TPA) and calcium ionophore A23187.	Tetradecanoylphorbol Acetate	68-99	interleukin 4	Homo sapiens	4-8
2535858-6	1989	The IL-4 gene is inducible after treatment of human T cell clone by phorbol-12-myristate-13-acetate (TPA) and calcium ionophore A23187.	Tetradecanoylphorbol Acetate	101-104	interleukin 4	Homo sapiens	4-8
2535858-7	1989	The 2.3-kb 5"-flanking region of the human IL-4 gene transiently transfected into Jurkat human T cell leukemia cells is activated efficiently in response to TPA and A23187 stimulation and, although less efficiently, by human T cell leukemia virus type I-encoded p40x or BPV-encoded E2 protein.	Tetradecanoylphorbol Acetate	157-160	interleukin 4	Homo sapiens	43-47
2793223-2	1989	When PBMC were stimulated with mitogen plus phorbol 12-myristate-13-acetate (PMA), the amount of TNF alpha was significantly decreased in culture supernatants from active patients or from the entire group of SLE patients studied.	Tetradecanoylphorbol Acetate	44-75	tumor necrosis factor	Homo sapiens	97-106
2793223-2	1989	When PBMC were stimulated with mitogen plus phorbol 12-myristate-13-acetate (PMA), the amount of TNF alpha was significantly decreased in culture supernatants from active patients or from the entire group of SLE patients studied.	Tetradecanoylphorbol Acetate	77-80	tumor necrosis factor	Homo sapiens	97-106
2473287-3	1989	The mRNA for ppET-1 was rapidly upregulated by O-tetradecanoylphorbol-13-acetate (TPA) (0.5 microM) and by ionomycin (5 microM) within 10 min of addition to the medium, but not by forskolin (50 microM).	Tetradecanoylphorbol Acetate	82-85	endothelin 1	Homo sapiens	13-19
2473287-4	1989	The rapid induction of ppET-1 mRNA by TPA or ionomycin occurred even in the presence of cycloheximide, indicating that the mRNA induction does not require de novo protein synthesis.	Tetradecanoylphorbol Acetate	38-41	endothelin 1	Homo sapiens	23-29
2536064-3	1989	Treatment of EoL-1 with interferon-gamma (IFN-gamma) for 5 days dramatically enhanced TPA-inducible CL, and IFN-alpha A had a similar effect.	Tetradecanoylphorbol Acetate	86-89	interferon gamma	Homo sapiens	24-40
2536064-3	1989	Treatment of EoL-1 with interferon-gamma (IFN-gamma) for 5 days dramatically enhanced TPA-inducible CL, and IFN-alpha A had a similar effect.	Tetradecanoylphorbol Acetate	86-89	interferon gamma	Homo sapiens	42-51
2536064-5	1989	Tumor necrosis factor (TNF) also enhanced TPA-inducible CL response of EoL-1 and, furthermore, was quite inhibitory to EoL-1 cell growth.	Tetradecanoylphorbol Acetate	42-45	tumor necrosis factor	Homo sapiens	0-21
2536064-5	1989	Tumor necrosis factor (TNF) also enhanced TPA-inducible CL response of EoL-1 and, furthermore, was quite inhibitory to EoL-1 cell growth.	Tetradecanoylphorbol Acetate	42-45	tumor necrosis factor	Homo sapiens	23-26
2531259-0	1989	Beta-endorphin and related peptides suppress phorbol myristate acetate-induced respiratory burst in human polymorphonuclear leukocytes.	Tetradecanoylphorbol Acetate	45-70	proopiomelanocortin	Homo sapiens	0-14
2531259-4	1989	With the exception of alpha-E, PMA-stimulated respiratory burst was suppressed by all POMC fragments tested.	Tetradecanoylphorbol Acetate	31-34	proopiomelanocortin	Homo sapiens	86-90
2531259-7	1989	beta-E and dT beta E both suppressed PMA-induced oxidative burst in human PMN at physiological concentrations (10(-16)M - 10(-10)M).	Tetradecanoylphorbol Acetate	37-40	proopiomelanocortin	Homo sapiens	0-6
2661946-2	1989	The present study was designed to: a) define a time in organogenesis when a vertebrate embryo model, the chicken, was sensitive to the phorbol ester 12-0-tetradecanoyl-13-acetate (TPA), and b) attempt a rescue of the embryos disturbed by TPA with simultaneous addition of insulin.	Tetradecanoylphorbol Acetate	180-183	insulin	Gallus gallus	272-279
2661946-5	1989	When intermediate doses of TPA (50 ng/embryo) were applied together with insulin (100 ng/embryo), the embryonic growth disturbance was largely antagonized.	Tetradecanoylphorbol Acetate	27-30	insulin	Gallus gallus	73-80
2494431-1	1989	The treatment of human HL-60 promyelocytic leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of tumor necrosis factor (TNF) transcript.	Tetradecanoylphorbol Acetate	63-99	tumor necrosis factor	Homo sapiens	138-159
2494431-1	1989	The treatment of human HL-60 promyelocytic leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of tumor necrosis factor (TNF) transcript.	Tetradecanoylphorbol Acetate	63-99	tumor necrosis factor	Homo sapiens	161-164
2494431-1	1989	The treatment of human HL-60 promyelocytic leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of tumor necrosis factor (TNF) transcript.	Tetradecanoylphorbol Acetate	101-104	tumor necrosis factor	Homo sapiens	138-159
2494431-1	1989	The treatment of human HL-60 promyelocytic leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of tumor necrosis factor (TNF) transcript.	Tetradecanoylphorbol Acetate	101-104	tumor necrosis factor	Homo sapiens	161-164
2494431-2	1989	The study reported here has examined TPA-induced signaling mechanisms responsible for the regulation of TNF gene expression in these cells.	Tetradecanoylphorbol Acetate	37-40	tumor necrosis factor	Homo sapiens	104-107
2494431-3	1989	Run-on assays demonstrated that TPA increases TNF mRNA levels by transcriptional activation of this gene.	Tetradecanoylphorbol Acetate	32-35	tumor necrosis factor	Homo sapiens	46-49
2494431-4	1989	The induction of TNF transcripts by TPA was inhibited by the isoquinolinesulfonamide derivative H7 but not by HA1004, suggesting that this effect of TPA is mediated by activation of protein kinase C. TPA treatment also resulted in increased arachidonic acid release.	Tetradecanoylphorbol Acetate	36-39	tumor necrosis factor	Homo sapiens	17-20
2494431-4	1989	The induction of TNF transcripts by TPA was inhibited by the isoquinolinesulfonamide derivative H7 but not by HA1004, suggesting that this effect of TPA is mediated by activation of protein kinase C. TPA treatment also resulted in increased arachidonic acid release.	Tetradecanoylphorbol Acetate	149-152	tumor necrosis factor	Homo sapiens	17-20
2494431-4	1989	The induction of TNF transcripts by TPA was inhibited by the isoquinolinesulfonamide derivative H7 but not by HA1004, suggesting that this effect of TPA is mediated by activation of protein kinase C. TPA treatment also resulted in increased arachidonic acid release.	Tetradecanoylphorbol Acetate	149-152	tumor necrosis factor	Homo sapiens	17-20
2464751-3	1989	Spectrophotometric analyses of 560 corticotropes from fractions enriched to 90% by counterflow centrifugation showed a 30% increase in the average area of the dark blue label for biotinylated CRH after a 1-h exposure to 10 nM AVP or after activation of protein kinase-C [by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or L calcium channels (by Bay K 8644).	Tetradecanoylphorbol Acetate	313-316	arginine vasopressin	Homo sapiens	226-229
2494431-6	1989	These findings suggest that TPA induces TNF gene expression through the formation of arachidonic acid metabolites.	Tetradecanoylphorbol Acetate	28-31	tumor necrosis factor	Homo sapiens	40-43
2494431-7	1989	Although indomethacin had no detectable effect on this induction of TNF transcripts, ketoconazole, an inhibitor of 5-lipoxygenase, blocked TPA-induced increases in TNF mRNA levels.	Tetradecanoylphorbol Acetate	139-142	arachidonate 5-lipoxygenase	Homo sapiens	115-129
2789690-12	1989	The observed decreases in catalase and SOD can be considered as part of the complex reprogramming of gene expression that is set in motion by phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	142-173	catalase	Homo sapiens	26-34
2494431-7	1989	Although indomethacin had no detectable effect on this induction of TNF transcripts, ketoconazole, an inhibitor of 5-lipoxygenase, blocked TPA-induced increases in TNF mRNA levels.	Tetradecanoylphorbol Acetate	139-142	tumor necrosis factor	Homo sapiens	164-167
2494431-9	1989	In contrast, the cyclooxygenase metabolite prostaglandin E2 inhibited the induction of TNF transcripts by TPA.	Tetradecanoylphorbol Acetate	106-109	tumor necrosis factor	Homo sapiens	87-90
2494431-10	1989	Taken together, these results suggest that TPA induces TNF gene expression through the arachidonic acid cascade and that the level of TNF transcripts is regulated by metabolites of the pathway, leukotriene B4 and prostaglandin E2.	Tetradecanoylphorbol Acetate	43-46	tumor necrosis factor	Homo sapiens	55-58
2538725-4	1989	Very low levels of fgr transcripts were also present in U937 promonocytic cells and increased in abundance with 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation.	Tetradecanoylphorbol Acetate	112-148	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	19-22
2538725-4	1989	Very low levels of fgr transcripts were also present in U937 promonocytic cells and increased in abundance with 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation.	Tetradecanoylphorbol Acetate	150-153	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	19-22
2538725-5	1989	The level of fgr transcripts began to increase 2 to 4 h after TPA addition, peaked at 8 h, and subsequently declined.	Tetradecanoylphorbol Acetate	62-65	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
2538725-6	1989	Since we found that the half-life of fgr mRNA was longer than 8 h, these changes are best explained by transient transcriptional activation of fgr during TPA-induced differentiation, although nuclear runoff experiments were not sensitive enough to detect this event.	Tetradecanoylphorbol Acetate	154-157	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	37-40
2538725-6	1989	Since we found that the half-life of fgr mRNA was longer than 8 h, these changes are best explained by transient transcriptional activation of fgr during TPA-induced differentiation, although nuclear runoff experiments were not sensitive enough to detect this event.	Tetradecanoylphorbol Acetate	154-157	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	143-146
2789690-12	1989	The observed decreases in catalase and SOD can be considered as part of the complex reprogramming of gene expression that is set in motion by phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	142-173	superoxide dismutase 1	Homo sapiens	39-42
2474814-2	1989	Pretreatment of acini with TPA (10(-6) M) for 5 min at 37 degrees C potentiated their subsequent response to stimulation by VIP at a dose range of 10(-8)-10(-6) M in that the treated pancreatic acini released more amylase than could be accounted for by the additive effects of VIP or TPA acting individually.	Tetradecanoylphorbol Acetate	27-30	vasoactive intestinal peptide	Rattus norvegicus	124-127
2474814-2	1989	Pretreatment of acini with TPA (10(-6) M) for 5 min at 37 degrees C potentiated their subsequent response to stimulation by VIP at a dose range of 10(-8)-10(-6) M in that the treated pancreatic acini released more amylase than could be accounted for by the additive effects of VIP or TPA acting individually.	Tetradecanoylphorbol Acetate	27-30	vasoactive intestinal peptide	Rattus norvegicus	277-280
2474814-2	1989	Pretreatment of acini with TPA (10(-6) M) for 5 min at 37 degrees C potentiated their subsequent response to stimulation by VIP at a dose range of 10(-8)-10(-6) M in that the treated pancreatic acini released more amylase than could be accounted for by the additive effects of VIP or TPA acting individually.	Tetradecanoylphorbol Acetate	284-287	vasoactive intestinal peptide	Rattus norvegicus	124-127
2474814-3	1989	This potentiation effect of TPA was still evident when isobutyl methylxanthine was given together with VIP.	Tetradecanoylphorbol Acetate	28-31	vasoactive intestinal peptide	Rattus norvegicus	103-106
2474814-5	1989	The TPA preincubation was found also to potentiate VIP-stimulated net increases in intracellular cyclic AMP (cAMP) levels.	Tetradecanoylphorbol Acetate	4-7	vasoactive intestinal peptide	Rattus norvegicus	51-54
2474814-7	1989	This suggested that TPA potentiated the response of rat pancreatic acini to VIP by modulating the cAMP system.	Tetradecanoylphorbol Acetate	20-23	vasoactive intestinal peptide	Rattus norvegicus	76-79
2544025-6	1989	In an ELISA, TNF-alpha production by phorbol myristate acetate (PMA)-stimulated mononuclear cells from SLE patients was significantly decreased (181.4 +/- 22.7 pg/ml vs. 533.0 +/- 81.9 pg/ml, p = 0.002).	Tetradecanoylphorbol Acetate	37-62	tumor necrosis factor	Homo sapiens	13-22
2481793-12	1989	Our data demonstrate that IL-2 and TNFs alpha and beta can act as growth factors for B-CLL cells under fully defined in vitro conditions, essentially without the need of TPA or anti-IgM as primary activation signals.	Tetradecanoylphorbol Acetate	170-173	interleukin 2	Homo sapiens	26-30
2546240-5	1989	This effect is additive with that of CGRP or CT. TPA (12-O-tetradecanoyl phorbol-13-acetate), an activator of protein kinase C, decreases the level of AChR but has no effect on the level of AChR alpha-subunit mRNA.	Tetradecanoylphorbol Acetate	49-52	calcitonin	Gallus gallus	37-41
2546240-5	1989	This effect is additive with that of CGRP or CT. TPA (12-O-tetradecanoyl phorbol-13-acetate), an activator of protein kinase C, decreases the level of AChR but has no effect on the level of AChR alpha-subunit mRNA.	Tetradecanoylphorbol Acetate	49-52	cholinergic receptor nicotinic delta subunit	Gallus gallus	151-155
2546240-5	1989	This effect is additive with that of CGRP or CT. TPA (12-O-tetradecanoyl phorbol-13-acetate), an activator of protein kinase C, decreases the level of AChR but has no effect on the level of AChR alpha-subunit mRNA.	Tetradecanoylphorbol Acetate	49-52	cholinergic receptor nicotinic delta subunit	Gallus gallus	190-194
2546240-5	1989	This effect is additive with that of CGRP or CT. TPA (12-O-tetradecanoyl phorbol-13-acetate), an activator of protein kinase C, decreases the level of AChR but has no effect on the level of AChR alpha-subunit mRNA.	Tetradecanoylphorbol Acetate	54-91	calcitonin	Gallus gallus	37-41
2546240-5	1989	This effect is additive with that of CGRP or CT. TPA (12-O-tetradecanoyl phorbol-13-acetate), an activator of protein kinase C, decreases the level of AChR but has no effect on the level of AChR alpha-subunit mRNA.	Tetradecanoylphorbol Acetate	54-91	cholinergic receptor nicotinic delta subunit	Gallus gallus	151-155
2546240-6	1989	Interestingly, TPA inhibits the increase of AChR alpha-subunit mRNA caused by TTX without affecting that produced by CGRP or CT.	Tetradecanoylphorbol Acetate	15-18	cholinergic receptor nicotinic delta subunit	Gallus gallus	44-48
2544025-6	1989	In an ELISA, TNF-alpha production by phorbol myristate acetate (PMA)-stimulated mononuclear cells from SLE patients was significantly decreased (181.4 +/- 22.7 pg/ml vs. 533.0 +/- 81.9 pg/ml, p = 0.002).	Tetradecanoylphorbol Acetate	64-67	tumor necrosis factor	Homo sapiens	13-22
3143423-6	1988	The thapsigargin/PMA treatment caused an increase in the interleukin-2 (IL-2) production of the lymphocytes, which was much higher than that caused by the PHA treatment, even in AIDS lymphocytes.	Tetradecanoylphorbol Acetate	17-20	interleukin 2	Homo sapiens	57-70
3143423-6	1988	The thapsigargin/PMA treatment caused an increase in the interleukin-2 (IL-2) production of the lymphocytes, which was much higher than that caused by the PHA treatment, even in AIDS lymphocytes.	Tetradecanoylphorbol Acetate	17-20	interleukin 2	Homo sapiens	72-76
2461263-3	1988	The present study demonstrates that 5-azacytidine, 12-O-tetradecanoylphorbol-13-acetate (TPA) and type beta-transforming growth factor (TGF-beta) significantly diminish the genomic 5-methyldeoxycytidine (5mdC) content of normal human bronchial epithelial cells concomitantly with the induction of squamous differentiation.	Tetradecanoylphorbol Acetate	51-87	ADAM metallopeptidase domain 11	Homo sapiens	205-208
2461263-3	1988	The present study demonstrates that 5-azacytidine, 12-O-tetradecanoylphorbol-13-acetate (TPA) and type beta-transforming growth factor (TGF-beta) significantly diminish the genomic 5-methyldeoxycytidine (5mdC) content of normal human bronchial epithelial cells concomitantly with the induction of squamous differentiation.	Tetradecanoylphorbol Acetate	89-92	ADAM metallopeptidase domain 11	Homo sapiens	205-208
3143423-7	1988	Moreover, the thapsigargin/PMA treatment stimulated the expression of the IL-2 receptors on both normal and AIDS lymphocytes, similar to the effect of PHA.	Tetradecanoylphorbol Acetate	27-30	interleukin 2	Homo sapiens	74-78
3142956-6	1988	The tumor-promoting phorbol diester, 12-o-tetradecanoyl-phorbol-13-acetate (TPA) also acted synergistically with the three CSFs (IL-3, GM-CSF, and M-CSF) to stimulate the proliferation of BDM-1 cells.	Tetradecanoylphorbol Acetate	37-74	interleukin 3	Mus musculus	129-133
3142956-6	1988	The tumor-promoting phorbol diester, 12-o-tetradecanoyl-phorbol-13-acetate (TPA) also acted synergistically with the three CSFs (IL-3, GM-CSF, and M-CSF) to stimulate the proliferation of BDM-1 cells.	Tetradecanoylphorbol Acetate	76-79	interleukin 3	Mus musculus	129-133
3142956-7	1988	The synergistic effect was observed when cells were pretreated with TPA and subsequently stimulated with IL-3.	Tetradecanoylphorbol Acetate	68-71	interleukin 3	Mus musculus	105-109
2850954-2	1988	Progesterone had no effect on PP5 release, but cholera toxin and 12-O-tetradecanoylphorbol 13-acetate stimulated PP5 release in a time- and concentration-dependent fashion.	Tetradecanoylphorbol Acetate	65-101	tissue factor pathway inhibitor 2	Homo sapiens	113-116
3200839-4	1988	Treatment with 10 nM phorbol 12-myristate 13-acetate (PMA) stimulated VIP peptide levels approximately 5-fold in SH-SY-5Y cells but did not increase appreciably VIP levels in the other subclones.	Tetradecanoylphorbol Acetate	21-52	vasoactive intestinal peptide	Homo sapiens	70-73
3059076-8	1988	In contrast, B cells from 3 other patients responded well to IL-2 when preactivated for 24 h with phorbolester TPA and ionomycin.	Tetradecanoylphorbol Acetate	111-114	interleukin 2	Homo sapiens	61-65
3200839-4	1988	Treatment with 10 nM phorbol 12-myristate 13-acetate (PMA) stimulated VIP peptide levels approximately 5-fold in SH-SY-5Y cells but did not increase appreciably VIP levels in the other subclones.	Tetradecanoylphorbol Acetate	54-57	vasoactive intestinal peptide	Homo sapiens	70-73
3191996-5	1988	In cells transformed with human or mouse A-raf carrying retroviruses TPA-stimulated PtdCho hydrolysis, but not CerPCho synthesis, suggesting independent regulation of these processes by the TPA-stimulated signal transduction system.	Tetradecanoylphorbol Acetate	69-72	Araf proto-oncogene, serine/threonine kinase	Mus musculus	41-46
2460460-0	1988	Modulation of adenylate cyclase in human keratinocytes by protein kinase C. Adenylate cyclase (ATP-pyrophosphate lyase (cyclizing); EC 4.6.1.1) in the human keratinocyte cell line SCC 12F was potentiated by 12-O-tetradecanoyl-phorbol-13-acetate (TPA), phorbol-12,13-diacetate, and 1,2-dioctanoylglycerol.	Tetradecanoylphorbol Acetate	207-244	adenylate cyclase 10	Homo sapiens	95-118
2460462-2	1988	Phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), partially mimics the stimulatory effect of IL-6 but reduces that effect of IL-1.	Tetradecanoylphorbol Acetate	15-51	interleukin 6	Homo sapiens	102-106
2460462-2	1988	Phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), partially mimics the stimulatory effect of IL-6 but reduces that effect of IL-1.	Tetradecanoylphorbol Acetate	53-56	interleukin 6	Homo sapiens	102-106
2460462-4	1988	These regulatory properties of TPA are also manifested in HepG2 cells transiently transfected with an indicator gene construct carrying the IL-1/IL-6 regulatory enhancer element of the rat alpha 1-acid glycoprotein gene.	Tetradecanoylphorbol Acetate	31-34	interleukin 6	Homo sapiens	145-149
2460462-5	1988	IL-6 and IL-1 act independently of TPA-inducible kinase C, and of changes in intracellular Ca2+ concentrations.	Tetradecanoylphorbol Acetate	35-38	interleukin 6	Homo sapiens	0-4
2460460-0	1988	Modulation of adenylate cyclase in human keratinocytes by protein kinase C. Adenylate cyclase (ATP-pyrophosphate lyase (cyclizing); EC 4.6.1.1) in the human keratinocyte cell line SCC 12F was potentiated by 12-O-tetradecanoyl-phorbol-13-acetate (TPA), phorbol-12,13-diacetate, and 1,2-dioctanoylglycerol.	Tetradecanoylphorbol Acetate	246-249	adenylate cyclase 10	Homo sapiens	95-118
3191996-5	1988	In cells transformed with human or mouse A-raf carrying retroviruses TPA-stimulated PtdCho hydrolysis, but not CerPCho synthesis, suggesting independent regulation of these processes by the TPA-stimulated signal transduction system.	Tetradecanoylphorbol Acetate	190-193	Araf proto-oncogene, serine/threonine kinase	Mus musculus	41-46
3048655-5	1988	TPA treatment of HT-29 G+ or G- cells induced early morphological and cytoskeletal alterations: the cells rounded up and lost their stress fibers with the associated caldesmon, alpha-actinin, and vinculin.	Tetradecanoylphorbol Acetate	0-3	actinin alpha 1	Homo sapiens	177-190
2460372-1	1988	We previously established a human T cell line, TPA-Mat, which can proliferate in response to not only interleukin-2 (IL-2), but also phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol-12,13-dibutyrate (PDBu).	Tetradecanoylphorbol Acetate	47-50	interleukin 2	Homo sapiens	102-115
2460372-1	1988	We previously established a human T cell line, TPA-Mat, which can proliferate in response to not only interleukin-2 (IL-2), but also phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol-12,13-dibutyrate (PDBu).	Tetradecanoylphorbol Acetate	47-50	interleukin 2	Homo sapiens	117-121
2460372-2	1988	The present study demonstrated that the PDBu-dependent growth of TPA-Mat cells was inhibited up to 90% by adenosine 3",5"-cyclic monophosphate (cAMP] raising agents such as forskolin, cholera toxin and 1-methyl-3-isobutyl-xanthine, and cAMP analogues, whereas the IL-2-stimulated TPA-Mat growth was slightly inhibited.	Tetradecanoylphorbol Acetate	65-68	interleukin 2	Homo sapiens	264-268
2460372-3	1988	These findings suggest that the signal transduction pathway of PDBu-induced growth, which should involve activation of protein kinase C, is sensitive to cAMP, and that it cannot be exactly identical to the signal transduction pathway of Il-2-induced growth in TPA-Mat cells.	Tetradecanoylphorbol Acetate	260-263	interleukin 2	Homo sapiens	237-241
3056410-1	1988	Previous work has demonstrated that pre-treatment of platelets with phorbol esters that activate protein kinase C eg phorbol 12-myristate 13-acetate (PMA) results in an inhibition of inositol phospholipid breakdown and granule secretion induced by physiological agonists such as thrombin and collagen.	Tetradecanoylphorbol Acetate	117-148	coagulation factor II, thrombin	Homo sapiens	279-287
3056410-1	1988	Previous work has demonstrated that pre-treatment of platelets with phorbol esters that activate protein kinase C eg phorbol 12-myristate 13-acetate (PMA) results in an inhibition of inositol phospholipid breakdown and granule secretion induced by physiological agonists such as thrombin and collagen.	Tetradecanoylphorbol Acetate	150-153	coagulation factor II, thrombin	Homo sapiens	279-287
3141047-8	1988	Only the ER-negative tumors possessing EGFR had significantly lower tPA levels than the ER-positive tumors (P less than 0.01).	Tetradecanoylphorbol Acetate	68-71	epidermal growth factor receptor	Homo sapiens	39-43
3141047-9	1988	Low tPA levels in breast cancers were, therefore, associated with ER negativity combined with EGFR positivity and may be an indication of poorer differentiation and prognosis.	Tetradecanoylphorbol Acetate	4-7	epidermal growth factor receptor	Homo sapiens	94-98
3052623-4	1988	When the HEL cells were induced to spread on fibronectin in the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA), the MoAbs reacted with the focal adhesion sites.	Tetradecanoylphorbol Acetate	76-112	fibronectin 1	Homo sapiens	45-56
3052623-4	1988	When the HEL cells were induced to spread on fibronectin in the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA), the MoAbs reacted with the focal adhesion sites.	Tetradecanoylphorbol Acetate	114-117	fibronectin 1	Homo sapiens	45-56
2850216-2	1988	PMN oxidative metabolism, assessed by chemiluminescence (CL), was significantly lower in PV patients after stimulation with leukotriene B4 (LTB4) and f-Met-Leu Phe (fMLP) (60% of control), whereas no difference in CL was seen after stimulation with phorbol myristate acetate (PMA) (120% of controls).	Tetradecanoylphorbol Acetate	249-274	formyl peptide receptor 1	Homo sapiens	165-169
2850216-2	1988	PMN oxidative metabolism, assessed by chemiluminescence (CL), was significantly lower in PV patients after stimulation with leukotriene B4 (LTB4) and f-Met-Leu Phe (fMLP) (60% of control), whereas no difference in CL was seen after stimulation with phorbol myristate acetate (PMA) (120% of controls).	Tetradecanoylphorbol Acetate	276-279	formyl peptide receptor 1	Homo sapiens	165-169
2846729-9	1988	In adherent PMNs, pretreatment with PMA potentiated the FMLP-induced O2-.	Tetradecanoylphorbol Acetate	36-39	formyl peptide receptor 1	Homo sapiens	56-60
3264806-0	1988	Phorbol myristate acetate induces IL-2 secretion by HUT 78 cells by a mechanism independent of protein kinase C translocation.	Tetradecanoylphorbol Acetate	0-25	interleukin 2	Homo sapiens	34-38
2846726-1	1988	Preincubation of human neutrophils with recombinant tumor necrosis factor alpha has previously been shown by us to enhance superoxide production of neutrophils in response to the chemotactic peptide formyl-methionyl-leucyl-phenylalanine, and the phorbol ester, phorbol myristate acetate.	Tetradecanoylphorbol Acetate	261-286	tumor necrosis factor	Homo sapiens	52-79
3169138-2	1988	The TPA-induced expression of c-fos mRNA was inhibited by H-7, a specific inhibitor of protein kinase C (PK-C).	Tetradecanoylphorbol Acetate	4-7	proline rich transmembrane protein 2	Homo sapiens	87-103
3169138-2	1988	The TPA-induced expression of c-fos mRNA was inhibited by H-7, a specific inhibitor of protein kinase C (PK-C).	Tetradecanoylphorbol Acetate	4-7	proline rich transmembrane protein 2	Homo sapiens	105-109
3169138-5	1988	Since PK-C in SH-SY5Y cells was activated by both TPA and DiC8 it is suggested that the activation of PK-C alone is not sufficient to induce differentiation in SH-SY5Y cells.	Tetradecanoylphorbol Acetate	50-53	proline rich transmembrane protein 2	Homo sapiens	6-10
2908233-1	1988	Forskolin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate stimulate prolactin and GH release from ovine anterior pituitary cells cultured in vitro.	Tetradecanoylphorbol Acetate	32-68	prolactin	Homo sapiens	79-88
2846730-9	1988	Likewise, while the lysate"s fMLP-specific inhibitor was heat stable, heating reduced the PMA-specific inhibition 56.5 +/- 10.4%.	Tetradecanoylphorbol Acetate	90-93	formyl peptide receptor 1	Homo sapiens	29-33
2846820-1	1988	In this study we have characterized and compared the regulation of the HT29 cell vasoactive intestinal peptide receptor/adenylate cyclase system (VIP-R/AC) by the VIP-R agonist peptide histidineisoleucineamide (PHI) and by activators of protein kinase C (PKC) including phorbol 12-myristate, 13-acetate (PMA) and mezerein.	Tetradecanoylphorbol Acetate	304-307	vasoactive intestinal peptide receptor 1	Homo sapiens	146-154
2846820-1	1988	In this study we have characterized and compared the regulation of the HT29 cell vasoactive intestinal peptide receptor/adenylate cyclase system (VIP-R/AC) by the VIP-R agonist peptide histidineisoleucineamide (PHI) and by activators of protein kinase C (PKC) including phorbol 12-myristate, 13-acetate (PMA) and mezerein.	Tetradecanoylphorbol Acetate	304-307	vasoactive intestinal peptide receptor 1	Homo sapiens	146-151
2856554-3	1988	One peptide, representing residues 508 to 530 of human prothrombin (p508-530), inhibits up to 70% of the specific binding of 125I-alpha-thrombin at concentrations of less than 100 nM, enhances the ability of thrombin to stimulate DNA synthesis and stimulates DNA synthesis in cells treated with 25 ng/ml phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	304-329	coagulation factor II, thrombin	Homo sapiens	58-66
2856554-3	1988	One peptide, representing residues 508 to 530 of human prothrombin (p508-530), inhibits up to 70% of the specific binding of 125I-alpha-thrombin at concentrations of less than 100 nM, enhances the ability of thrombin to stimulate DNA synthesis and stimulates DNA synthesis in cells treated with 25 ng/ml phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	304-329	coagulation factor II, thrombin	Homo sapiens	136-144
2856554-3	1988	One peptide, representing residues 508 to 530 of human prothrombin (p508-530), inhibits up to 70% of the specific binding of 125I-alpha-thrombin at concentrations of less than 100 nM, enhances the ability of thrombin to stimulate DNA synthesis and stimulates DNA synthesis in cells treated with 25 ng/ml phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	331-334	coagulation factor II, thrombin	Homo sapiens	58-66
2856554-3	1988	One peptide, representing residues 508 to 530 of human prothrombin (p508-530), inhibits up to 70% of the specific binding of 125I-alpha-thrombin at concentrations of less than 100 nM, enhances the ability of thrombin to stimulate DNA synthesis and stimulates DNA synthesis in cells treated with 25 ng/ml phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	331-334	coagulation factor II, thrombin	Homo sapiens	136-144
2846297-4	1988	The thrombin-induced enhancement of inositol phospholipid metabolism was strongly inhibited by the presence of neomycin whereas the TPA- or ionomycin-induced increase in inositol [32P]polyphospholipids remained unaffected.	Tetradecanoylphorbol Acetate	132-135	coagulation factor II, thrombin	Homo sapiens	4-12
3263853-1	1988	The acute monocytic leukemia cell line THP-1 secretes predominantly IL-1 beta after treatment with bacterial lipopolysaccharide and tumour promoting phorbol ester (PMA).	Tetradecanoylphorbol Acetate	164-167	GLI family zinc finger 2	Homo sapiens	39-44
3263853-1	1988	The acute monocytic leukemia cell line THP-1 secretes predominantly IL-1 beta after treatment with bacterial lipopolysaccharide and tumour promoting phorbol ester (PMA).	Tetradecanoylphorbol Acetate	164-167	interleukin 1 beta	Homo sapiens	68-77
2971556-5	1988	Treatment of the cells with TPA enhanced the binding of beads coated with human plasma fibronectin to the cells, as observed after incubation for 6 h with the beads.	Tetradecanoylphorbol Acetate	28-31	fibronectin 1	Homo sapiens	87-98
2902085-4	1988	To test whether AA release occurs via a mechanism which is sequential to and dependent upon PI hydrolysis, we used the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), which activates protein kinase C. TPA treatment blocked BK-mediated PI hydrolysis in MDCK-D1 cells, while at the same time and at similar concentrations enhancing BK-mediated AA release.	Tetradecanoylphorbol Acetate	134-170	kininogen 1	Canis lupus familiaris	234-236
2902085-4	1988	To test whether AA release occurs via a mechanism which is sequential to and dependent upon PI hydrolysis, we used the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), which activates protein kinase C. TPA treatment blocked BK-mediated PI hydrolysis in MDCK-D1 cells, while at the same time and at similar concentrations enhancing BK-mediated AA release.	Tetradecanoylphorbol Acetate	134-170	kininogen 1	Canis lupus familiaris	341-343
2902085-4	1988	To test whether AA release occurs via a mechanism which is sequential to and dependent upon PI hydrolysis, we used the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), which activates protein kinase C. TPA treatment blocked BK-mediated PI hydrolysis in MDCK-D1 cells, while at the same time and at similar concentrations enhancing BK-mediated AA release.	Tetradecanoylphorbol Acetate	172-175	kininogen 1	Canis lupus familiaris	234-236
2902085-4	1988	To test whether AA release occurs via a mechanism which is sequential to and dependent upon PI hydrolysis, we used the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), which activates protein kinase C. TPA treatment blocked BK-mediated PI hydrolysis in MDCK-D1 cells, while at the same time and at similar concentrations enhancing BK-mediated AA release.	Tetradecanoylphorbol Acetate	172-175	kininogen 1	Canis lupus familiaris	341-343
2902085-5	1988	Thus, TPA treatment dissociated BK-mediated AA release from PI hydrolysis.	Tetradecanoylphorbol Acetate	6-9	kininogen 1	Canis lupus familiaris	32-34
2844758-1	1988	The effects of the tumor promotor, 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA), on the intra- and extracellular distribution of transferrin receptors and rates of iron uptake were studied in normal developing myogenic cells and myogenic cells transformed with a temperature-sensitive strain of the Rous sarcoma virus.	Tetradecanoylphorbol Acetate	86-89	transferrin	Homo sapiens	140-151
2970356-6	1988	Endogenous production of IL-2 after stimulation with PHA and phorbol myristate acetate was positive in 3/9 CD3- and in 8/8 CD3+, CD4-, CD8- clones.	Tetradecanoylphorbol Acetate	61-86	interleukin 2	Homo sapiens	25-29
2970356-6	1988	Endogenous production of IL-2 after stimulation with PHA and phorbol myristate acetate was positive in 3/9 CD3- and in 8/8 CD3+, CD4-, CD8- clones.	Tetradecanoylphorbol Acetate	61-86	CD4 molecule	Homo sapiens	129-132
2902085-8	1988	BK-mediated lysophospholipid production was enhanced by pretreatment with TPA, suggesting that the mechanism of AA release before and after treatment with TPA was the same.	Tetradecanoylphorbol Acetate	74-77	kininogen 1	Canis lupus familiaris	0-2
2902085-8	1988	BK-mediated lysophospholipid production was enhanced by pretreatment with TPA, suggesting that the mechanism of AA release before and after treatment with TPA was the same.	Tetradecanoylphorbol Acetate	155-158	kininogen 1	Canis lupus familiaris	0-2
2902085-9	1988	BK-mediated AA release and lysophospholipid production was dependent on the presence of extracellular calcium, while the enhanced responses to BK in the presence of TPA were not dependent on the presence of extracellular calcium.	Tetradecanoylphorbol Acetate	165-168	kininogen 1	Canis lupus familiaris	143-145
2902930-3	1988	The proliferative response was dependent upon an operational interleukin-2 (IL-2) system and exhibited a high degree of specificity; sn-1,2-diC8 was twice as active as racemic-1,2-diC8, and diC8 and TPA were not synergistic.	Tetradecanoylphorbol Acetate	199-202	interleukin 2	Homo sapiens	76-80
3046744-3	1988	Tumor necrosis factor increased phorbol myristate acetate-induced hydrogen peroxide production 8- to 20-fold in peripheral blood monocytes and peritoneal macrophages in vitro in a dose-dependent manner.	Tetradecanoylphorbol Acetate	32-57	tumor necrosis factor	Homo sapiens	0-21
3046744-4	1988	Similarly, tumor necrosis factor increased phorbol myristate acetate-induced peroxide production 2.3-fold in monocytes isolated from nine patients following an i.v.	Tetradecanoylphorbol Acetate	43-68	tumor necrosis factor	Homo sapiens	11-32
3263307-8	1988	TPA also induced the maximal expression of SmIg and GP-70 in cells derived from patients in this group.	Tetradecanoylphorbol Acetate	0-3	embigin	Homo sapiens	52-57
2848088-5	1988	Combined addition of 10 mumol ionomycin/l and 16 nmol TPA/l resulted in additive stimulation of CGRP and calcitonin secretory responses.	Tetradecanoylphorbol Acetate	54-57	calcitonin related polypeptide alpha	Homo sapiens	96-100
2848088-5	1988	Combined addition of 10 mumol ionomycin/l and 16 nmol TPA/l resulted in additive stimulation of CGRP and calcitonin secretory responses.	Tetradecanoylphorbol Acetate	54-57	calcitonin related polypeptide alpha	Homo sapiens	105-115
2848088-4	1988	12-O-tetradecanoylphorbol-13-acetate (TPA; 16 nmol/l) did not affect the concentration of Cai2+, but caused a gradual rise of the secretion of CGRP and calcitonin.	Tetradecanoylphorbol Acetate	0-36	calcitonin related polypeptide alpha	Homo sapiens	143-147
2848088-4	1988	12-O-tetradecanoylphorbol-13-acetate (TPA; 16 nmol/l) did not affect the concentration of Cai2+, but caused a gradual rise of the secretion of CGRP and calcitonin.	Tetradecanoylphorbol Acetate	0-36	calcitonin related polypeptide alpha	Homo sapiens	152-162
2848088-4	1988	12-O-tetradecanoylphorbol-13-acetate (TPA; 16 nmol/l) did not affect the concentration of Cai2+, but caused a gradual rise of the secretion of CGRP and calcitonin.	Tetradecanoylphorbol Acetate	38-41	calcitonin related polypeptide alpha	Homo sapiens	143-147
2848088-4	1988	12-O-tetradecanoylphorbol-13-acetate (TPA; 16 nmol/l) did not affect the concentration of Cai2+, but caused a gradual rise of the secretion of CGRP and calcitonin.	Tetradecanoylphorbol Acetate	38-41	calcitonin related polypeptide alpha	Homo sapiens	152-162
3139757-3	1988	Elevated H2O2 release in response to PMA was observed in resident macrophages after a 48-h incubation with IFN-gamma, TNF-alpha, TNF-beta, or CSF-GM.	Tetradecanoylphorbol Acetate	37-40	interferon gamma	Mus musculus	107-116
3139757-3	1988	Elevated H2O2 release in response to PMA was observed in resident macrophages after a 48-h incubation with IFN-gamma, TNF-alpha, TNF-beta, or CSF-GM.	Tetradecanoylphorbol Acetate	37-40	tumor necrosis factor	Mus musculus	118-127
2848088-8	1988	Forskolin synergistically enhanced (P less than 0.01) the ionomycin-induced early phase as well as the TPA-induced late phase of the CGRP and calcitonin secretory responses.	Tetradecanoylphorbol Acetate	103-106	calcitonin related polypeptide alpha	Homo sapiens	133-137
2848088-8	1988	Forskolin synergistically enhanced (P less than 0.01) the ionomycin-induced early phase as well as the TPA-induced late phase of the CGRP and calcitonin secretory responses.	Tetradecanoylphorbol Acetate	103-106	calcitonin related polypeptide alpha	Homo sapiens	142-152
2843535-4	1988	The protein kinase C activator, phorbol 12-myristate 13-acetate, at concentrations (2-20 nM) which did not deplete protein kinase C, stimulated LH-beta mRNA levels 2-5-fold after 24 h. Higher concentrations of phorbol 12-myristate 13-acetate, which depleted protein kinase C activity, substantially reduced the ability of 100 pM GnRH to stimulate increases in LH-beta mRNA levels.	Tetradecanoylphorbol Acetate	32-63	luteinizing hormone subunit beta	Rattus norvegicus	144-151
2843535-4	1988	The protein kinase C activator, phorbol 12-myristate 13-acetate, at concentrations (2-20 nM) which did not deplete protein kinase C, stimulated LH-beta mRNA levels 2-5-fold after 24 h. Higher concentrations of phorbol 12-myristate 13-acetate, which depleted protein kinase C activity, substantially reduced the ability of 100 pM GnRH to stimulate increases in LH-beta mRNA levels.	Tetradecanoylphorbol Acetate	32-63	luteinizing hormone subunit beta	Rattus norvegicus	360-367
2843541-12	1988	The 18-h TPA pretreatment diminished by 30-50% the induction of receptor protein synthesis by epinephrine or angiotensin II.	Tetradecanoylphorbol Acetate	9-12	angiotensinogen	Rattus norvegicus	109-123
3139753-1	1988	We have previously shown that Lyt-2- L3T4- T cells from the lymph nodes of MRL/lpr/lpr mice could respond to 12-O-tetradecanoylphorbol-2-acetate (TPA) and A23187 by proliferation, IL-2 secretion, and IL-2R (IL-2R) expression.	Tetradecanoylphorbol Acetate	146-149	Fas (TNF receptor superfamily member 6)	Mus musculus	79-82
3139753-5	1988	TPA and A23187 synergistically induced both IL-2R and c-myc mRNA expression by the lpr Lyt-2- L3T4- T cells, as well as by normal T cells.	Tetradecanoylphorbol Acetate	0-3	Fas (TNF receptor superfamily member 6)	Mus musculus	83-86
3139753-7	1988	Cycloheximide treatment caused the TPA/A23187-stimulated lpr cells to express large amounts of c-myc mRNA, but not IL-2R mRNA.	Tetradecanoylphorbol Acetate	35-38	Fas (TNF receptor superfamily member 6)	Mus musculus	57-60
3047115-5	1988	Pretreatment of WFB cells with phorbol 12-myristate 13-acetate profoundly inhibited inositol phosphate formation evoked by vasopressin and bombesin, but enhanced to some extent inositol phosphate formation stimulated by PDGF.	Tetradecanoylphorbol Acetate	31-62	arginine vasopressin	Rattus norvegicus	123-134
3139753-1	1988	We have previously shown that Lyt-2- L3T4- T cells from the lymph nodes of MRL/lpr/lpr mice could respond to 12-O-tetradecanoylphorbol-2-acetate (TPA) and A23187 by proliferation, IL-2 secretion, and IL-2R (IL-2R) expression.	Tetradecanoylphorbol Acetate	146-149	Fas (TNF receptor superfamily member 6)	Mus musculus	83-86
2844586-1	1988	Treatment of human neutrophils with C-reactive protein (CRP) causes a concentration-dependent in the extent of activation of superoxide production and of granule secretion, induced by phorbol-12-myristate-13-acetate (PMA) or N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF).	Tetradecanoylphorbol Acetate	184-215	C-reactive protein	Homo sapiens	36-54
3262641-7	1988	This was not due solely to a property of the 145-2C11 antibody, because both TPA and the F23.1 anti-TCR mAb also provoked a faster modulation of the TCR in lpr DN LNC.	Tetradecanoylphorbol Acetate	77-80	Fas (TNF receptor superfamily member 6)	Mus musculus	156-159
3264151-1	1988	The inhibitory effect of phorbol-12-myristate-13-acetate (PMA) on the Ca2+-mobilization mechanisms by arginine vasopressin (AVP) and angiotensin II (AII) was analysed in rat vascular smooth muscle cells (VSMC) in culture.	Tetradecanoylphorbol Acetate	25-56	arginine vasopressin	Rattus norvegicus	111-122
3264151-1	1988	The inhibitory effect of phorbol-12-myristate-13-acetate (PMA) on the Ca2+-mobilization mechanisms by arginine vasopressin (AVP) and angiotensin II (AII) was analysed in rat vascular smooth muscle cells (VSMC) in culture.	Tetradecanoylphorbol Acetate	25-56	arginine vasopressin	Rattus norvegicus	124-127
3264151-1	1988	The inhibitory effect of phorbol-12-myristate-13-acetate (PMA) on the Ca2+-mobilization mechanisms by arginine vasopressin (AVP) and angiotensin II (AII) was analysed in rat vascular smooth muscle cells (VSMC) in culture.	Tetradecanoylphorbol Acetate	25-56	angiotensinogen	Rattus norvegicus	133-147
3264151-1	1988	The inhibitory effect of phorbol-12-myristate-13-acetate (PMA) on the Ca2+-mobilization mechanisms by arginine vasopressin (AVP) and angiotensin II (AII) was analysed in rat vascular smooth muscle cells (VSMC) in culture.	Tetradecanoylphorbol Acetate	25-56	angiotensinogen	Rattus norvegicus	149-152
3264151-1	1988	The inhibitory effect of phorbol-12-myristate-13-acetate (PMA) on the Ca2+-mobilization mechanisms by arginine vasopressin (AVP) and angiotensin II (AII) was analysed in rat vascular smooth muscle cells (VSMC) in culture.	Tetradecanoylphorbol Acetate	58-61	arginine vasopressin	Rattus norvegicus	111-122
3264151-1	1988	The inhibitory effect of phorbol-12-myristate-13-acetate (PMA) on the Ca2+-mobilization mechanisms by arginine vasopressin (AVP) and angiotensin II (AII) was analysed in rat vascular smooth muscle cells (VSMC) in culture.	Tetradecanoylphorbol Acetate	58-61	arginine vasopressin	Rattus norvegicus	124-127
3264151-1	1988	The inhibitory effect of phorbol-12-myristate-13-acetate (PMA) on the Ca2+-mobilization mechanisms by arginine vasopressin (AVP) and angiotensin II (AII) was analysed in rat vascular smooth muscle cells (VSMC) in culture.	Tetradecanoylphorbol Acetate	58-61	angiotensinogen	Rattus norvegicus	133-147
2844586-1	1988	Treatment of human neutrophils with C-reactive protein (CRP) causes a concentration-dependent in the extent of activation of superoxide production and of granule secretion, induced by phorbol-12-myristate-13-acetate (PMA) or N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF).	Tetradecanoylphorbol Acetate	184-215	C-reactive protein	Homo sapiens	56-59
2844586-1	1988	Treatment of human neutrophils with C-reactive protein (CRP) causes a concentration-dependent in the extent of activation of superoxide production and of granule secretion, induced by phorbol-12-myristate-13-acetate (PMA) or N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF).	Tetradecanoylphorbol Acetate	217-220	C-reactive protein	Homo sapiens	36-54
2844586-1	1988	Treatment of human neutrophils with C-reactive protein (CRP) causes a concentration-dependent in the extent of activation of superoxide production and of granule secretion, induced by phorbol-12-myristate-13-acetate (PMA) or N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF).	Tetradecanoylphorbol Acetate	217-220	C-reactive protein	Homo sapiens	56-59
2971552-4	1988	In order to observe levels of interleukin 2 mRNA, it was necessary to use phorbol myristate acetate (PMA) in addition to either lectins or anti-CD3 antibodies.	Tetradecanoylphorbol Acetate	74-99	interleukin 2	Homo sapiens	30-43
2900701-1	1988	Repeated twice-weekly applications of promoting doses of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal skin of female adult SENCAR mice led to a reduction in numbers per unit area of epidermal Thy-1+ dendritic cells.	Tetradecanoylphorbol Acetate	57-93	thymus cell antigen 1, theta	Mus musculus	204-209
2900701-1	1988	Repeated twice-weekly applications of promoting doses of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal skin of female adult SENCAR mice led to a reduction in numbers per unit area of epidermal Thy-1+ dendritic cells.	Tetradecanoylphorbol Acetate	95-98	thymus cell antigen 1, theta	Mus musculus	204-209
2900701-3	1988	Topical administration of TPA (2 micrograms) twice weekly for 4 or 8 weeks led to reductions in Thy-1+ cell numbers of 52 and 61%, respectively, whereas a single treatment was without effect.	Tetradecanoylphorbol Acetate	26-29	thymus cell antigen 1, theta	Mus musculus	96-101
2971552-4	1988	In order to observe levels of interleukin 2 mRNA, it was necessary to use phorbol myristate acetate (PMA) in addition to either lectins or anti-CD3 antibodies.	Tetradecanoylphorbol Acetate	101-104	interleukin 2	Homo sapiens	30-43
3170640-7	1988	A potent activator of PKC, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced a minimal mitogenic response in pig aortic EC when added alone but acted synergistically with low concentrations of fetal calf serum to greatly stimulate DNA synthesis.	Tetradecanoylphorbol Acetate	27-63	PKC	Sus scrofa	22-25
2457532-2	1988	At 170 pg/ml, the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) caused a 50% inhibition of heparin-binding growth factor type one (HBGF-1)-stimulated DNA synthesis in human adult large vessel endothelial cells.	Tetradecanoylphorbol Acetate	33-69	fibroblast growth factor 1	Homo sapiens	143-149
2457532-2	1988	At 170 pg/ml, the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) caused a 50% inhibition of heparin-binding growth factor type one (HBGF-1)-stimulated DNA synthesis in human adult large vessel endothelial cells.	Tetradecanoylphorbol Acetate	71-74	fibroblast growth factor 1	Homo sapiens	143-149
2457532-3	1988	TPA at 1 ng/ml completely inhibited HBGF-1-stimulated proliferation.	Tetradecanoylphorbol Acetate	0-3	fibroblast growth factor 1	Homo sapiens	36-42
2457532-4	1988	TPA at 5 ng/ml reduced specific HBGF-1 receptor sites from 6600 per cell to 3200 per cell without affecting receptor affinity.	Tetradecanoylphorbol Acetate	0-3	fibroblast growth factor 1	Homo sapiens	32-38
3170640-7	1988	A potent activator of PKC, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced a minimal mitogenic response in pig aortic EC when added alone but acted synergistically with low concentrations of fetal calf serum to greatly stimulate DNA synthesis.	Tetradecanoylphorbol Acetate	65-68	PKC	Sus scrofa	22-25
3417778-2	1988	Treatment of these cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent activator of protein kinase C, was found to cause a rapid dispersal of AChR clusters, as monitored by fluorescence microscopy of cells labeled with tetramethylrhodamine-conjugated alpha-bungarotoxin.	Tetradecanoylphorbol Acetate	48-84	cholinergic receptor nicotinic delta subunit	Gallus gallus	172-176
3170640-8	1988	Furthermore, pig aortic EC treated with TPA for 24 h to down-regulate PKC exhibited only 25% of the serum-stimulated mitogenic activity of control cultures.	Tetradecanoylphorbol Acetate	40-43	PKC	Sus scrofa	70-73
3417778-2	1988	Treatment of these cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent activator of protein kinase C, was found to cause a rapid dispersal of AChR clusters, as monitored by fluorescence microscopy of cells labeled with tetramethylrhodamine-conjugated alpha-bungarotoxin.	Tetradecanoylphorbol Acetate	86-89	cholinergic receptor nicotinic delta subunit	Gallus gallus	172-176
3417778-4	1988	Analysis of the phosphorylation pattern of immunoprecipitable AChR subunits showed that the gamma- and delta-subunits are phosphorylated by endogenous protein kinase activity in the intact muscle cells, and that the delta-subunit displays increased phosphorylation in response to TPA.	Tetradecanoylphorbol Acetate	280-283	cholinergic receptor nicotinic delta subunit	Gallus gallus	62-66
2842422-5	1988	Addition of RA or the tumor promoter, phorbol 12-myristic 13-acetate (PMA), to HPBM or THP-1 cells resulted in significant increases in 5NT activity with opposite effects on ADA activity.	Tetradecanoylphorbol Acetate	70-73	GLI family zinc finger 2	Homo sapiens	87-92
3417778-7	1988	Like TPA, carbamylcholine enhances the phosphorylation of the delta-subunit of AChR.	Tetradecanoylphorbol Acetate	5-8	cholinergic receptor nicotinic delta subunit	Gallus gallus	79-83
3411128-7	1988	Exposure to PMA, which activates the respiratory burst oxidase, induced phosphorylation of the 23-kDa, 48-kDa group, and 130-kDa proteins that were phosphorylated after stimulation by EIgG.	Tetradecanoylphorbol Acetate	12-15	mediator complex subunit 23	Mus musculus	95-128
3137260-6	1988	(90,000), which co-migrated with purified plasma factor B. Incubation of U-937 cells with the immunostimulants PMA, LPS, IFN-gamma, and IL-1 resulted in a dose-dependent augmentation of factor B production.	Tetradecanoylphorbol Acetate	111-114	interleukin 1 beta	Homo sapiens	136-140
2840269-10	1988	When added alone, EGF and TPA increased cAMP production y 2.0-fold and 2.5-fold over controls at 24 h. Again, IGF-I was ineffective.	Tetradecanoylphorbol Acetate	26-29	insulin like growth factor 1	Homo sapiens	110-115
2464741-4	1988	Most but not all of the protein bands phosphorylated at tyrosine in response to thrombin were also tyrosine phosphorylated in response to chilling or the combination of ionophore A23187 and tetradecanoylphorbol acetate.	Tetradecanoylphorbol Acetate	190-218	coagulation factor II, thrombin	Homo sapiens	80-88
3413092-2	1988	Based on the known human lysozyme amino acid sequence, oligonucleotides were synthesized and used as probes to screen a phorbol 12-myristate 13-acetate-treated U937 cDNA library.	Tetradecanoylphorbol Acetate	120-151	lysozyme	Homo sapiens	25-33
3165051-6	1988	In contrast, both PDGF-1 and PDGF-2 transcripts were detected in HL-60 cells and monocytes induced with TPA, while only PDGF-1 mRNA was found in TPA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	145-148	GLI family zinc finger 2	Homo sapiens	157-162
2846218-11	1988	This decreased responsiveness was restricted to C5a- and fMLP-stimulated superoxide production since phorbol myristate acetate (PMA)-stimulated responses were comparable to controls.	Tetradecanoylphorbol Acetate	101-126	complement C5a receptor 1	Homo sapiens	48-51
2846218-11	1988	This decreased responsiveness was restricted to C5a- and fMLP-stimulated superoxide production since phorbol myristate acetate (PMA)-stimulated responses were comparable to controls.	Tetradecanoylphorbol Acetate	101-126	formyl peptide receptor 1	Homo sapiens	57-61
3403071-1	1988	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced changes in cytoplasmic pH, cytoplasmic Ca2+-concentration, rate of DNA synthesis, and concentration and activity of protein kinase C (PKC) were studied in human monoblastoid cell lines.	Tetradecanoylphorbol Acetate	0-36	proline rich transmembrane protein 2	Homo sapiens	167-183
3403071-1	1988	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced changes in cytoplasmic pH, cytoplasmic Ca2+-concentration, rate of DNA synthesis, and concentration and activity of protein kinase C (PKC) were studied in human monoblastoid cell lines.	Tetradecanoylphorbol Acetate	0-36	proline rich transmembrane protein 2	Homo sapiens	185-188
3403071-1	1988	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced changes in cytoplasmic pH, cytoplasmic Ca2+-concentration, rate of DNA synthesis, and concentration and activity of protein kinase C (PKC) were studied in human monoblastoid cell lines.	Tetradecanoylphorbol Acetate	38-41	proline rich transmembrane protein 2	Homo sapiens	167-183
3403071-1	1988	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced changes in cytoplasmic pH, cytoplasmic Ca2+-concentration, rate of DNA synthesis, and concentration and activity of protein kinase C (PKC) were studied in human monoblastoid cell lines.	Tetradecanoylphorbol Acetate	38-41	proline rich transmembrane protein 2	Homo sapiens	185-188
2900139-16	1988	These results show that TPA mimics the effect of insulin on phosphorylation, but not activation, of acetyl-CoA carboxylase, i.e. that these two events can be dissociated.	Tetradecanoylphorbol Acetate	24-27	insulin	Homo sapiens	49-56
3261728-8	1988	These observations suggest that the sustained activation of PKC by the phorbol esters could induce continuous growth of the IL-2-dependent TPA-Mat cells.	Tetradecanoylphorbol Acetate	139-142	interleukin 2	Homo sapiens	124-128
2841359-1	1988	Human neutrophils, when stimulated with phorbol myristate acetate or fMet-Leu-Phe in the presence or absence of cytochalasin B, released metalloproteinases that catalytically inactivated the plasma serine proteinase inhibitor, alpha 1-antitrypsin.	Tetradecanoylphorbol Acetate	40-65	serpin family A member 1	Homo sapiens	227-246
3261728-1	1988	A selected clone from an IL-2-dependent human T-cell line was persistently propagated in the presence of phorbol esters with the ability to activate protein kinase C (PKC), such as 12-O-tetradecanoylphorbol-13-acetate (TPA) or phorbol-12,13-dibutylate (PDBu).	Tetradecanoylphorbol Acetate	181-217	interleukin 2	Homo sapiens	25-29
3261728-2	1988	Thus, a TPA(PDBu)-dependent T-cell line, designated TPA-Mat, was established from IL-2-dependent T cells.	Tetradecanoylphorbol Acetate	8-11	interleukin 2	Homo sapiens	82-86
2463192-1	1988	Growth hormone-releasing hormone (GHRH) and the phorbol ester tetradecanoylphorbol acetate (TPA) each stimulated a rapid and extensive (up to 15-fold) increase in the secretion of growth hormone from cultured ovine anterior pituitary cells.	Tetradecanoylphorbol Acetate	92-95	growth hormone 1	Homo sapiens	180-194
3261728-2	1988	Thus, a TPA(PDBu)-dependent T-cell line, designated TPA-Mat, was established from IL-2-dependent T cells.	Tetradecanoylphorbol Acetate	52-55	interleukin 2	Homo sapiens	82-86
3261728-5	1988	Therefore, the phorbol esters substituted for IL-2 and may be directly involved in transduction of growth signals in TPA-Mat cells.	Tetradecanoylphorbol Acetate	117-120	interleukin 2	Homo sapiens	46-50
3139787-1	1988	We have reported that human interferon-gamma (IFN-gamma) genomic DNA is expressed after transfection into a mouse T-lymphoblastoid cell line and expression can be enhanced by both interleukin 2 (IL2) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	231-234	interferon gamma	Homo sapiens	28-44
3139787-1	1988	We have reported that human interferon-gamma (IFN-gamma) genomic DNA is expressed after transfection into a mouse T-lymphoblastoid cell line and expression can be enhanced by both interleukin 2 (IL2) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	231-234	interferon gamma	Homo sapiens	46-55
2463477-7	1988	Transcriptional run-on studies demonstrated that fibroblasts constitutively transcribed GM-CSF, and transcription was enhanced 3.0-fold by TNF alpha and 2.5-fold by TPA and was unchanged by cycloheximide.	Tetradecanoylphorbol Acetate	165-168	tumor necrosis factor	Homo sapiens	139-154
2844948-4	1988	The relative biological potencies of mezerein and the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), to inhibit thyroid function in vitro corresponded to their abilities to activate PKC.	Tetradecanoylphorbol Acetate	69-105	PKC	Sus scrofa	194-197
2844948-4	1988	The relative biological potencies of mezerein and the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), to inhibit thyroid function in vitro corresponded to their abilities to activate PKC.	Tetradecanoylphorbol Acetate	107-110	PKC	Sus scrofa	194-197
3139787-0	1988	Characterization of interleukin 2 and phorbol myristate acetate augmentation of expression of transfected human interferon-gamma genomic DNA.	Tetradecanoylphorbol Acetate	38-63	interferon gamma	Homo sapiens	112-128
3139787-1	1988	We have reported that human interferon-gamma (IFN-gamma) genomic DNA is expressed after transfection into a mouse T-lymphoblastoid cell line and expression can be enhanced by both interleukin 2 (IL2) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	204-229	interferon gamma	Homo sapiens	28-44
3139787-1	1988	We have reported that human interferon-gamma (IFN-gamma) genomic DNA is expressed after transfection into a mouse T-lymphoblastoid cell line and expression can be enhanced by both interleukin 2 (IL2) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	204-229	interferon gamma	Homo sapiens	46-55
3136245-1	1988	The purpose of this investigation was to examine the potential beneficial effect of the selective endoperoxide/thromboxane A2 (TxA2) receptor antagonist, sulotroban (BM 13.177), on tissue type plasminogen activator (tPA)-induced coronary thrombolysis in the dog.	Tetradecanoylphorbol Acetate	216-219	tissue-type plasminogen activator	Canis lupus familiaris	181-214
2463192-3	1988	TPA induced a much smaller (26-78%), though still significant, increase in cellular cyclic AMP levels.	Tetradecanoylphorbol Acetate	0-3	adenine phosphoribosyltransferase	Homo sapiens	91-94
2463192-6	1988	In contrast TPA when combined with maximally effective concentrations of either GHRH, forskolin or IBMX caused additional release of growth hormone, suggesting that the TPA-induced secretion involved a cyclic AMP-independent process.	Tetradecanoylphorbol Acetate	12-15	growth hormone 1	Homo sapiens	133-147
2463192-6	1988	In contrast TPA when combined with maximally effective concentrations of either GHRH, forskolin or IBMX caused additional release of growth hormone, suggesting that the TPA-induced secretion involved a cyclic AMP-independent process.	Tetradecanoylphorbol Acetate	169-172	growth hormone releasing hormone	Homo sapiens	80-84
2463192-6	1988	In contrast TPA when combined with maximally effective concentrations of either GHRH, forskolin or IBMX caused additional release of growth hormone, suggesting that the TPA-induced secretion involved a cyclic AMP-independent process.	Tetradecanoylphorbol Acetate	169-172	growth hormone 1	Homo sapiens	133-147
3145412-3	1988	A DNA-binding protein with the same sequence specificity (and therefore presumed to be NF-kappa B itself) can be induced in pre-B cells, T cells, and nonlymphoid cells by phorbol 12-acetate-13-myristate (PMA); however, it is not clear whether the induced factor can activate transcription in nonlymphoid cells as NF-kappa B does in B cells.	Tetradecanoylphorbol Acetate	204-207	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-97
3145412-3	1988	A DNA-binding protein with the same sequence specificity (and therefore presumed to be NF-kappa B itself) can be induced in pre-B cells, T cells, and nonlymphoid cells by phorbol 12-acetate-13-myristate (PMA); however, it is not clear whether the induced factor can activate transcription in nonlymphoid cells as NF-kappa B does in B cells.	Tetradecanoylphorbol Acetate	204-207	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	313-323
2463192-7	1988	However, TPA also markedly potentiated the cellular cyclic AMP accumulation due to each of these agents.	Tetradecanoylphorbol Acetate	9-12	adenine phosphoribosyltransferase	Homo sapiens	59-62
2463192-8	1988	That TPA induced stimulation of basal and GHRH-stimulated cyclic AMP levels measured in the presence of IBMX suggests an action affecting cyclic AMP synthesis.	Tetradecanoylphorbol Acetate	5-8	growth hormone releasing hormone	Homo sapiens	42-46
2463192-8	1988	That TPA induced stimulation of basal and GHRH-stimulated cyclic AMP levels measured in the presence of IBMX suggests an action affecting cyclic AMP synthesis.	Tetradecanoylphorbol Acetate	5-8	adenine phosphoribosyltransferase	Homo sapiens	65-68
2463192-8	1988	That TPA induced stimulation of basal and GHRH-stimulated cyclic AMP levels measured in the presence of IBMX suggests an action affecting cyclic AMP synthesis.	Tetradecanoylphorbol Acetate	5-8	adenine phosphoribosyltransferase	Homo sapiens	145-148
2463192-10	1988	The two actions of TPA, one on secretion and one on cyclic AMP metabolism, may result from activation of some common event possibly involving protein kinase C. Our results suggest that GHRH and TPA activate independent pathways regulating growth hormone secretion.	Tetradecanoylphorbol Acetate	19-22	adenine phosphoribosyltransferase	Homo sapiens	59-62
3137654-0	1988	Modulation of high-affinity interleukin 2 receptors on activated human T lymphocytes by activators of protein kinase C. Phorbol myristate acetate (PMA) and 1-oleoyl-2-acetyl-rac-glycerol (OAG) are shown to induce a rapid (within 30 min) down-regulation of the capacity of activated human T lymphocytes to bind interleukin 2.	Tetradecanoylphorbol Acetate	120-145	interleukin 2	Homo sapiens	28-41
2463192-10	1988	The two actions of TPA, one on secretion and one on cyclic AMP metabolism, may result from activation of some common event possibly involving protein kinase C. Our results suggest that GHRH and TPA activate independent pathways regulating growth hormone secretion.	Tetradecanoylphorbol Acetate	19-22	growth hormone releasing hormone	Homo sapiens	185-189
2463192-10	1988	The two actions of TPA, one on secretion and one on cyclic AMP metabolism, may result from activation of some common event possibly involving protein kinase C. Our results suggest that GHRH and TPA activate independent pathways regulating growth hormone secretion.	Tetradecanoylphorbol Acetate	19-22	growth hormone 1	Homo sapiens	239-253
2463192-10	1988	The two actions of TPA, one on secretion and one on cyclic AMP metabolism, may result from activation of some common event possibly involving protein kinase C. Our results suggest that GHRH and TPA activate independent pathways regulating growth hormone secretion.	Tetradecanoylphorbol Acetate	194-197	adenine phosphoribosyltransferase	Homo sapiens	59-62
2463192-10	1988	The two actions of TPA, one on secretion and one on cyclic AMP metabolism, may result from activation of some common event possibly involving protein kinase C. Our results suggest that GHRH and TPA activate independent pathways regulating growth hormone secretion.	Tetradecanoylphorbol Acetate	194-197	growth hormone 1	Homo sapiens	239-253
2840070-1	1988	Treatment of the cells of the 311 cell line, a pluripotent mouse teratocarcinoma cell line, with 12-O-tetradecanoylphorbol-13-acetate (TPA) modulates c-mos expression.	Tetradecanoylphorbol Acetate	97-133	Moloney sarcoma oncogene	Mus musculus	150-155
3137654-0	1988	Modulation of high-affinity interleukin 2 receptors on activated human T lymphocytes by activators of protein kinase C. Phorbol myristate acetate (PMA) and 1-oleoyl-2-acetyl-rac-glycerol (OAG) are shown to induce a rapid (within 30 min) down-regulation of the capacity of activated human T lymphocytes to bind interleukin 2.	Tetradecanoylphorbol Acetate	147-150	interleukin 2	Homo sapiens	28-41
2840070-1	1988	Treatment of the cells of the 311 cell line, a pluripotent mouse teratocarcinoma cell line, with 12-O-tetradecanoylphorbol-13-acetate (TPA) modulates c-mos expression.	Tetradecanoylphorbol Acetate	135-138	Moloney sarcoma oncogene	Mus musculus	150-155
2840070-2	1988	Transient suppression of 6.1 and 4.6 kilobases (kb) transcripts and activation of 1.8 transcript indicate that TPA mediates concurrently positive and negative regulation of c-mos transcription.	Tetradecanoylphorbol Acetate	111-114	Moloney sarcoma oncogene	Mus musculus	173-178
2840070-3	1988	The results show that the c-mos gene is a TPA-modulated gene.	Tetradecanoylphorbol Acetate	42-45	Moloney sarcoma oncogene	Mus musculus	26-31
2903640-1	1988	The level of the Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA-1) encoded by the Bam HI-K fragment of EBV DNA remained unchanged in P3HR-1 cells after induction of the productive cycle of virus replication by sodium-n-butyrate and 12-o-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	243-279	EBNA-1	Human gammaherpesvirus 4	70-76
3412642-3	1988	This effect was abolished in cells which had been depleted of protein kinase C (PKC) by prior exposure to PMA.	Tetradecanoylphorbol Acetate	106-109	proline rich transmembrane protein 2	Homo sapiens	62-78
3412642-3	1988	This effect was abolished in cells which had been depleted of protein kinase C (PKC) by prior exposure to PMA.	Tetradecanoylphorbol Acetate	106-109	proline rich transmembrane protein 2	Homo sapiens	80-83
3132461-9	1988	However, PMA-induced desensitization caused a 75% loss of the histamine and a 67% loss of the thrombin effects.	Tetradecanoylphorbol Acetate	9-12	coagulation factor II, thrombin	Homo sapiens	94-102
3133109-4	1988	Treatment with TPA in vivo resulted in about 2-fold increases in the phosphorylations of epidermal proteins with molecular weights of 34,000 and 40,000 and isoelectric points of 4.7-5.1 and 5.2-6.2 (p34 and p40, respectively).	Tetradecanoylphorbol Acetate	15-18	alpha- and gamma-adaptin binding protein	Mus musculus	199-202
3133109-6	1988	Inhibitors of PKC, such as chlorpromazine, quercetin, and staurosporine inhibited these increases in phosphorylations of p34 and p40 on TPA treatment.	Tetradecanoylphorbol Acetate	136-139	alpha- and gamma-adaptin binding protein	Mus musculus	121-124
2906508-4	1988	Ionomycin in combination with the phorbol ester, TPA, mimics the TRH-elicited PRL release, and SRIH partly inhibited this effect.	Tetradecanoylphorbol Acetate	49-52	prolactin	Rattus norvegicus	78-81
2903640-1	1988	The level of the Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA-1) encoded by the Bam HI-K fragment of EBV DNA remained unchanged in P3HR-1 cells after induction of the productive cycle of virus replication by sodium-n-butyrate and 12-o-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	281-284	EBNA-1	Human gammaherpesvirus 4	70-76
3260781-2	1988	Deficiency in PHA-stimulated IL-2 production by cells from SLE patients was repaired by the addition of PMA, but not ionomycin.	Tetradecanoylphorbol Acetate	104-107	interleukin 2	Homo sapiens	29-33
3260781-0	1988	Deficient phytohemagglutinin-induced interleukin-2 activity in patients with inactive systemic lupus erythematosus is correctable by the addition of phorbol myristate acetate.	Tetradecanoylphorbol Acetate	149-174	interleukin 2	Homo sapiens	37-50
3260781-3	1988	PMA alone did not stimulate IL-2 production but, in concert with PHA, induced IL-2 synthesis.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Homo sapiens	78-82
3260781-1	1988	In systemic lupus erythematosus (SLE) patients, the production of interleukin-2 (IL-2) by blood T lymphocytes in response to stimulation with phytohemagglutinin (PHA) either alone or with phorbol myristate acetate (PMA) or ionomycin, a Ca2+ ionophore, was examined.	Tetradecanoylphorbol Acetate	188-213	interleukin 2	Homo sapiens	66-79
3260781-1	1988	In systemic lupus erythematosus (SLE) patients, the production of interleukin-2 (IL-2) by blood T lymphocytes in response to stimulation with phytohemagglutinin (PHA) either alone or with phorbol myristate acetate (PMA) or ionomycin, a Ca2+ ionophore, was examined.	Tetradecanoylphorbol Acetate	188-213	interleukin 2	Homo sapiens	81-85
2455575-8	1988	Induction by TPA led to the expression of fibronectin and factor V, which were not detected on nontreated cells.	Tetradecanoylphorbol Acetate	13-16	fibronectin 1	Homo sapiens	42-53
3260781-4	1988	Moreover, PMA was effective in the repair of the deficiency of PHA-induced IL-2 production by both T4+ and T8+ subsets.	Tetradecanoylphorbol Acetate	10-13	interleukin 2	Homo sapiens	75-79
3260781-1	1988	In systemic lupus erythematosus (SLE) patients, the production of interleukin-2 (IL-2) by blood T lymphocytes in response to stimulation with phytohemagglutinin (PHA) either alone or with phorbol myristate acetate (PMA) or ionomycin, a Ca2+ ionophore, was examined.	Tetradecanoylphorbol Acetate	215-218	interleukin 2	Homo sapiens	66-79
3260781-1	1988	In systemic lupus erythematosus (SLE) patients, the production of interleukin-2 (IL-2) by blood T lymphocytes in response to stimulation with phytohemagglutinin (PHA) either alone or with phorbol myristate acetate (PMA) or ionomycin, a Ca2+ ionophore, was examined.	Tetradecanoylphorbol Acetate	215-218	interleukin 2	Homo sapiens	81-85
3164726-9	1988	When permeabilized cells were exposed to Ca2+ concentrations in the range of [Ca2+]f measured in cells treated with vasopressin the addition of PMA approximately doubled PGE2 production.	Tetradecanoylphorbol Acetate	144-147	arginine vasopressin	Rattus norvegicus	116-127
2839519-8	1988	Agrin-induced receptor aggregation also was inhibited by phorbol 12-myristate 13-acetate, an activator of protein kinase C, and by inhibitors of energy metabolism.	Tetradecanoylphorbol Acetate	57-88	agrin	Gallus gallus	0-5
3383343-0	1988	Distribution of catalase and its modulation by 12-O-tetradecanoylphorbol-13-acetate in murine dermis and subpopulations of keratinocytes differing in their stages of differentiation.	Tetradecanoylphorbol Acetate	47-83	catalase	Mus musculus	16-24
3383343-1	1988	Topical treatment of female SENCAR mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced both dermal and epidermal catalase-specific activities 38% and 51% within 6 h and 18 h of promoter application, respectively.	Tetradecanoylphorbol Acetate	45-81	catalase	Mus musculus	122-130
3383343-1	1988	Topical treatment of female SENCAR mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced both dermal and epidermal catalase-specific activities 38% and 51% within 6 h and 18 h of promoter application, respectively.	Tetradecanoylphorbol Acetate	83-86	catalase	Mus musculus	122-130
3383343-5	1988	Pretreatment of the epidermis for 16-18 h with TPA (2 micrograms) uniformly reduced catalase-specific activity 46-52% in all keratinocyte subpopulations prepared by Percoll gradient centrifugation.	Tetradecanoylphorbol Acetate	47-50	catalase	Mus musculus	84-92
3383343-6	1988	Similarly, plots of catalase units per cell versus extracted protein per cell suggested 55-60% decreases in catalase activity in basal and spinous cell keratinocytes of TPA treated epidermis.	Tetradecanoylphorbol Acetate	169-172	catalase	Mus musculus	20-28
3383343-6	1988	Similarly, plots of catalase units per cell versus extracted protein per cell suggested 55-60% decreases in catalase activity in basal and spinous cell keratinocytes of TPA treated epidermis.	Tetradecanoylphorbol Acetate	169-172	catalase	Mus musculus	108-116
3383343-8	1988	Collectively, these studies suggest that: (i) TPA reduces the capacity for H2O2 detoxification by catalase throughout the epidermis; and (ii) activity measurements on unfractionated epidermal preparations may not be representative of the basal cell keratinocyte population.	Tetradecanoylphorbol Acetate	46-49	catalase	Mus musculus	98-106
3288620-4	1988	In this paper, we demonstrate that the diacylglycerol analogues PMA (4 beta-phorbol 12-myristate 13-acetate) and mezerein (both possessing 12 beta- and 13 alpha-O-linked substituents as well as a 4 beta-hydroxyl group) each increase the Vmax of the glucose transporter as does insulin.	Tetradecanoylphorbol Acetate	64-67	insulin	Homo sapiens	277-284
2967865-0	1988	Identification of IL-6 as a T cell-derived factor that enhances the proliferative response of thymocytes to IL-4 and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	117-142	interleukin 6	Mus musculus	18-22
2839841-3	1988	We have induced the expression of nerve growth factor (NGF) receptors on cultured human melanocytes with phorbol 12-tetradecanoate 13-acetate and have correlated this event with the appearance of a more differentiated, dendritic morphology.	Tetradecanoylphorbol Acetate	105-141	nerve growth factor	Homo sapiens	34-53
2839841-3	1988	We have induced the expression of nerve growth factor (NGF) receptors on cultured human melanocytes with phorbol 12-tetradecanoate 13-acetate and have correlated this event with the appearance of a more differentiated, dendritic morphology.	Tetradecanoylphorbol Acetate	105-141	nerve growth factor	Homo sapiens	55-58
3288620-4	1988	In this paper, we demonstrate that the diacylglycerol analogues PMA (4 beta-phorbol 12-myristate 13-acetate) and mezerein (both possessing 12 beta- and 13 alpha-O-linked substituents as well as a 4 beta-hydroxyl group) each increase the Vmax of the glucose transporter as does insulin.	Tetradecanoylphorbol Acetate	69-107	insulin	Homo sapiens	277-284
3288620-7	1988	Pretreatment of the myocytes with PMA resulted in desensitization of subsequent glucose uptake to stimulation by phenylephrine, but had no effect on stimulation of glucose uptake by phospholipase C or by insulin, indicating that PMA pretreatment primarily desensitizes agonist-induced polyphosphoinositide hydrolysis which, as we have previously shown, is not involved in the insulin-induced generation of diacylglycerol.	Tetradecanoylphorbol Acetate	34-37	insulin	Homo sapiens	376-383
3133247-5	1988	These data point to a continuously elevated PLA2 activity in the presence of TPA and CH.	Tetradecanoylphorbol Acetate	77-80	phospholipase A2 group IB	Homo sapiens	44-48
3130982-6	1988	After a 2-day treatment with 10 nM TPA, PK-C activity was reduced 80-90% in both cell lines regardless of its intracellular distribution.	Tetradecanoylphorbol Acetate	35-38	proline rich transmembrane protein 2	Homo sapiens	40-44
3382400-0	1988	Cytochrome P450 induction by phenobarbital (PB) is inhibited by 12-O-tetradecanoylphorbol-13-acetate (TPA): evidence that protein kinase C regulates induction.	Tetradecanoylphorbol Acetate	64-100	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
3382400-0	1988	Cytochrome P450 induction by phenobarbital (PB) is inhibited by 12-O-tetradecanoylphorbol-13-acetate (TPA): evidence that protein kinase C regulates induction.	Tetradecanoylphorbol Acetate	102-105	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
3138974-4	1988	The transient inhibition by vasopressin was mimicked by either 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) or ionophore A23187.	Tetradecanoylphorbol Acetate	114-117	arginine vasopressin	Rattus norvegicus	28-39
3130982-7	1988	Immunoblotting of cell extracts from HL-60/ADR cells or HL-60 cells following treatment with TPA revealed increased levels of a 52-kDa species of similar mass to M-kinase.	Tetradecanoylphorbol Acetate	93-96	aldo-keto reductase family 1 member B	Homo sapiens	43-46
3138977-9	1988	Treatment of the cells with 12-O-tetradecanoylphorbol 13-acetate completely abolishes the response to EGF and to sub-optimal doses of bradykinin, suggesting a negative-feedback function of protein kinase C. Pretreatment of the cells with pertussis toxin has no effect on inositol phosphate formation induced by either EGF or bradykinin.	Tetradecanoylphorbol Acetate	28-64	kininogen 1	Homo sapiens	134-144
3138977-9	1988	Treatment of the cells with 12-O-tetradecanoylphorbol 13-acetate completely abolishes the response to EGF and to sub-optimal doses of bradykinin, suggesting a negative-feedback function of protein kinase C. Pretreatment of the cells with pertussis toxin has no effect on inositol phosphate formation induced by either EGF or bradykinin.	Tetradecanoylphorbol Acetate	28-64	kininogen 1	Homo sapiens	325-335
3130982-8	1988	Coincident with these changes after TPA treatment was a reduction in Ca2+ and phospholipid-independent phosphorylation of vinculin in vitro in extracts from HL-60/ADR cells, whereas HL-60 cells exhibited an elevation of this phosphoprotein.	Tetradecanoylphorbol Acetate	36-39	aldo-keto reductase family 1 member B	Homo sapiens	163-166
3130982-9	1988	The phosphorylation of vinculin in TPA-treated HL-60 cells or untreated HL-60/ADR cells was blocked by antibodies to protein kinase C.	Tetradecanoylphorbol Acetate	35-38	proline rich transmembrane protein 2	Homo sapiens	117-133
3260374-1	1988	Expression of the epidermal growth factor (EGF) receptor gene is stimulated by EGF and the phorbol ester, 4 beta-phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	106-144	epidermal growth factor receptor	Homo sapiens	18-56
2967092-5	1988	Ionomycin (100 nM) and TPA (and/or OAG), when applied together, reproduced the biphasic pattern of pepsinogen secretion, suggesting that the signalling pathways utilized by both types of agonist contribute to the response evoked by cholecystokinin-hormone stimulation.	Tetradecanoylphorbol Acetate	23-26	cholecystokinin	Homo sapiens	232-247
2967092-15	1988	Prestimulation of cells with TPA or OAG prevented the aequorin transient caused by cholecystokinin and vice versa, suggesting that TPA, OAG and cholecystokinin activate the same pathways of Ca2+ entry into the cytosol from the intracellular store(s) or the extracellular space.	Tetradecanoylphorbol Acetate	29-32	cholecystokinin	Homo sapiens	83-98
2967092-15	1988	Prestimulation of cells with TPA or OAG prevented the aequorin transient caused by cholecystokinin and vice versa, suggesting that TPA, OAG and cholecystokinin activate the same pathways of Ca2+ entry into the cytosol from the intracellular store(s) or the extracellular space.	Tetradecanoylphorbol Acetate	29-32	cholecystokinin	Homo sapiens	144-159
2967092-15	1988	Prestimulation of cells with TPA or OAG prevented the aequorin transient caused by cholecystokinin and vice versa, suggesting that TPA, OAG and cholecystokinin activate the same pathways of Ca2+ entry into the cytosol from the intracellular store(s) or the extracellular space.	Tetradecanoylphorbol Acetate	131-134	cholecystokinin	Homo sapiens	83-98
3260374-1	1988	Expression of the epidermal growth factor (EGF) receptor gene is stimulated by EGF and the phorbol ester, 4 beta-phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	146-149	epidermal growth factor receptor	Homo sapiens	18-56
2836390-8	1988	Long-term pretreatment with PMA greatly reduced the contribution of agonist-induced desensitization to the angiotensin II response; in contrast, the extent of desensitization occurring during incubation of WB cells with epinephrine was unaltered by long-term treatment with PMA suggesting that an additional mechanism may be involved in alpha 1-adrenergic receptor desensitization.	Tetradecanoylphorbol Acetate	28-31	angiotensinogen	Rattus norvegicus	107-121
3370225-3	1988	PMA and concanavalin A together, but not individually, also increase the levels of the activity of the glycolytic enzymes in peripheral lymphocytes treated for 48 h. The increase in hexokinase activity induced by PMA plus concanavalin A appeared to be due to the expression of the isoenzyme form, hexokinase II.	Tetradecanoylphorbol Acetate	0-3	hexokinase 1	Homo sapiens	182-192
3370225-3	1988	PMA and concanavalin A together, but not individually, also increase the levels of the activity of the glycolytic enzymes in peripheral lymphocytes treated for 48 h. The increase in hexokinase activity induced by PMA plus concanavalin A appeared to be due to the expression of the isoenzyme form, hexokinase II.	Tetradecanoylphorbol Acetate	0-3	hexokinase 1	Homo sapiens	297-307
3370227-2	1988	TPA also stimulated minor incorporation of [32 P]Pi into most integral membrane proteins, including band 3, glycophorin A, the band 4.5 region (glucose transporter) and band 7.	Tetradecanoylphorbol Acetate	0-3	glycophorin A (MNS blood group)	Homo sapiens	108-121
3163272-7	1988	The results indicate that CD18-dependent adhesion, like DNA synthesis, is controlled by phorbol esters in a manner unrelated to the translocation of protein kinase C and that the control mechanism might involve forms of protein kinase C which are subject to stable down-modulation following TPA adaption of the cells.	Tetradecanoylphorbol Acetate	291-294	integrin subunit beta 2	Homo sapiens	26-30
2453228-6	1988	CSF-1, GM-CSF, and IL-3 could also synergize with TPA; CSF-1 cooperated with 1-oleoyl-2-acetylglycerol (OAG), both sets of results pointing to an interaction with protein kinase C. LPS completely abolished the CSF-1-mediated stimulation of DNA synthesis.	Tetradecanoylphorbol Acetate	50-53	interleukin 3	Mus musculus	19-23
3163923-1	1988	Incubation of slices of caudato-putamen, cerebral cortex and hippocampus for 5 to 15 minutes with phorbol 12,13-dibutyrate (PDB) or phorbol 12-myristate 13-acetate (PMA) increased potassium evoked cholecystokinin (CCK) release from 139% to 296% of control.	Tetradecanoylphorbol Acetate	132-163	cholecystokinin	Homo sapiens	197-212
3138125-7	1988	Peripheral blood T-lymphocyte IL 2 production at onset of IDDM was normal under basal conditions, and upon optimal stimulation with concanavalin A (ConA) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	158-183	interleukin 2	Homo sapiens	30-34
3138125-7	1988	Peripheral blood T-lymphocyte IL 2 production at onset of IDDM was normal under basal conditions, and upon optimal stimulation with concanavalin A (ConA) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	185-188	interleukin 2	Homo sapiens	30-34
3131117-3	1988	PRL had no detectable effects on 45Ca2+ uptake or efflux, and the mitogenic effects of PRL could not be reproduced by the calcium ionophore A23187 alone or in combination with the tumor-promoting phorbol ester 12-O-tetra-decanoyl-phorbol-13 acetate (TPA).	Tetradecanoylphorbol Acetate	250-253	prolactin	Rattus norvegicus	87-90
2839411-6	1988	Stimulation of T cells with Con A or with the combination of ionomycin plus phorbol myristate acetate produced a marked increase of TAP expression.	Tetradecanoylphorbol Acetate	76-101	CD59 molecule (CD59 blood group)	Homo sapiens	132-135
2838524-3	1988	The treatment with IFN gamma increased this rate two- to threefold when phorbol myristate acetate (PMA) was used as the stimulus.	Tetradecanoylphorbol Acetate	72-97	interferon gamma	Homo sapiens	19-28
2838524-3	1988	The treatment with IFN gamma increased this rate two- to threefold when phorbol myristate acetate (PMA) was used as the stimulus.	Tetradecanoylphorbol Acetate	99-102	interferon gamma	Homo sapiens	19-28
3163923-1	1988	Incubation of slices of caudato-putamen, cerebral cortex and hippocampus for 5 to 15 minutes with phorbol 12,13-dibutyrate (PDB) or phorbol 12-myristate 13-acetate (PMA) increased potassium evoked cholecystokinin (CCK) release from 139% to 296% of control.	Tetradecanoylphorbol Acetate	132-163	cholecystokinin	Homo sapiens	214-217
3258883-2	1988	Substantial levels of IL-2 responsiveness were induced in T8+ cells by lectin, Con A, mAb directed against the CD3 Ag, OKT3, Ca2+ ionophore, ionomycin or phorbol ester, PMA.	Tetradecanoylphorbol Acetate	169-172	interleukin 2	Homo sapiens	22-26
3163921-2	1988	12-O-Tetradecanoyl phorbol -13-acetate (TPA, 10(-7) M), which stimulates protein kinase C activity in soluble fractions of glomerular homogenates, suppressed angiotensin II actions on inositol phosphate production and PGE2.	Tetradecanoylphorbol Acetate	0-38	angiotensinogen	Homo sapiens	158-172
3163921-2	1988	12-O-Tetradecanoyl phorbol -13-acetate (TPA, 10(-7) M), which stimulates protein kinase C activity in soluble fractions of glomerular homogenates, suppressed angiotensin II actions on inositol phosphate production and PGE2.	Tetradecanoylphorbol Acetate	40-43	angiotensinogen	Homo sapiens	158-172
3163921-4	1988	1-(5-Isoquinolinyl)-2-methylpiperazine (H-7), which inhibits protein kinase C activity in soluble fractions of glomerular homogenates, prevented TPA induced suppression of angiotensin II actions on inositol phosphate production and PGE2.	Tetradecanoylphorbol Acetate	145-148	angiotensinogen	Homo sapiens	172-186
2834371-11	1988	Treatment of PC12 cells with the protein kinase C activator phorbol 12-myristate 13-acetate alone elevated prepro-NPY mRNA marginally, but the phorbol ester plus forskolin elicited 20-70-fold increases, which were further enhanced to over 200-fold by dexamethasone and the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	60-91	neuropeptide Y	Rattus norvegicus	114-117
18584664-4	1988	4beta-Phorbol 12-myristate 13-acetate (PMA) was essential for inducible excretion of the erythroid differentiation factor (EDF).	Tetradecanoylphorbol Acetate	0-37	inhibin subunit beta A	Homo sapiens	89-121
2835011-1	1988	Myeloperoxidase gene transcription in isolated nuclei from HL-60 cells induced to differentiate into granulocytes by dimethyl sulfoxide or into macrophages by 12-O-tetradecanoylphorbol-13-acetate was studied by dot-blot hybridization of a myeloperoxidase cDNA to the 32P-labeled nuclear transcripts.	Tetradecanoylphorbol Acetate	159-195	myeloperoxidase	Homo sapiens	0-15
3129045-9	1988	Phorbol myristate acetate (PMA) stimulated FDC-P1 cells and was able to abrogate the PT inhibition of IL 3 stimulation of these cells, suggesting but not establishing that IL 3 may mediate its proliferative effects through activating protein kinase C.	Tetradecanoylphorbol Acetate	0-25	interleukin 3	Mus musculus	102-106
3129045-9	1988	Phorbol myristate acetate (PMA) stimulated FDC-P1 cells and was able to abrogate the PT inhibition of IL 3 stimulation of these cells, suggesting but not establishing that IL 3 may mediate its proliferative effects through activating protein kinase C.	Tetradecanoylphorbol Acetate	27-30	interleukin 3	Mus musculus	102-106
3129045-9	1988	Phorbol myristate acetate (PMA) stimulated FDC-P1 cells and was able to abrogate the PT inhibition of IL 3 stimulation of these cells, suggesting but not establishing that IL 3 may mediate its proliferative effects through activating protein kinase C.	Tetradecanoylphorbol Acetate	27-30	interleukin 3	Mus musculus	172-176
18584664-4	1988	4beta-Phorbol 12-myristate 13-acetate (PMA) was essential for inducible excretion of the erythroid differentiation factor (EDF).	Tetradecanoylphorbol Acetate	0-37	inhibin subunit beta A	Homo sapiens	123-126
18584664-4	1988	4beta-Phorbol 12-myristate 13-acetate (PMA) was essential for inducible excretion of the erythroid differentiation factor (EDF).	Tetradecanoylphorbol Acetate	39-42	inhibin subunit beta A	Homo sapiens	89-121
3163274-1	1988	Induced differentiation of Friend erythroleukemia cells can be continuously and reversibly inhibited by phorbol ester tumor promoters, e.g. 12-O-tetradecanoylphorbol-13-acetate (TPA), for many years, allowing us to study the mechanisms of differentiation and its inhibition by TPA.	Tetradecanoylphorbol Acetate	140-176	plasminogen activator, tissue type	Homo sapiens	178-181
3163274-1	1988	Induced differentiation of Friend erythroleukemia cells can be continuously and reversibly inhibited by phorbol ester tumor promoters, e.g. 12-O-tetradecanoylphorbol-13-acetate (TPA), for many years, allowing us to study the mechanisms of differentiation and its inhibition by TPA.	Tetradecanoylphorbol Acetate	140-176	plasminogen activator, tissue type	Homo sapiens	277-280
18584664-4	1988	4beta-Phorbol 12-myristate 13-acetate (PMA) was essential for inducible excretion of the erythroid differentiation factor (EDF).	Tetradecanoylphorbol Acetate	39-42	inhibin subunit beta A	Homo sapiens	123-126
2458497-5	1988	Flow cytometric analyses using the McAb H2B4 revealed that the amount of p60c-src expression in K562 cells markedly decreased during TPA induced differentiation.	Tetradecanoylphorbol Acetate	133-136	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	78-81
2452078-5	1988	The effects of bFGF on PRL secretion are potentiated by the addition of estradiol (maximally effective dose 100 pg/ml approximately 10(-10) M) and are further increased by the addition of the phorbol ester, phorbol myristate acetate.	Tetradecanoylphorbol Acetate	207-232	prolactin	Rattus norvegicus	23-26
2896072-4	1988	The addition of phorbol myristic acetate (PMA), which is not stimulatory by itself, can enhance the synergistic effect of mAb on IFN-gamma production.	Tetradecanoylphorbol Acetate	42-45	interferon gamma	Homo sapiens	129-138
2838420-5	1988	In contrast, opsonized zymosan and FMLP enhanced the release of LTB4 and LTB4-omega-oxidation products from cells pretreated with PMA.	Tetradecanoylphorbol Acetate	130-133	formyl peptide receptor 1	Homo sapiens	35-39
3366904-1	1988	Regulation of tumor necrosis factor (TNF) gene expression was investigated in resting human monocytes and in 12-O-tetradecanoylphorbol-13-acetate (TPA) activated monocytes.	Tetradecanoylphorbol Acetate	109-145	tumor necrosis factor	Homo sapiens	14-35
3366904-1	1988	Regulation of tumor necrosis factor (TNF) gene expression was investigated in resting human monocytes and in 12-O-tetradecanoylphorbol-13-acetate (TPA) activated monocytes.	Tetradecanoylphorbol Acetate	109-145	tumor necrosis factor	Homo sapiens	37-40
3366904-1	1988	Regulation of tumor necrosis factor (TNF) gene expression was investigated in resting human monocytes and in 12-O-tetradecanoylphorbol-13-acetate (TPA) activated monocytes.	Tetradecanoylphorbol Acetate	147-150	tumor necrosis factor	Homo sapiens	14-35
3366904-1	1988	Regulation of tumor necrosis factor (TNF) gene expression was investigated in resting human monocytes and in 12-O-tetradecanoylphorbol-13-acetate (TPA) activated monocytes.	Tetradecanoylphorbol Acetate	147-150	tumor necrosis factor	Homo sapiens	37-40
3366904-3	1988	However, in TPA-activated monocytes, TNF mRNA was first detectable by 3 h and reached maximal levels by 12 h of drug exposure.	Tetradecanoylphorbol Acetate	12-15	tumor necrosis factor	Homo sapiens	37-40
3366904-4	1988	Using run-on transcription assays, the TNF gene was transcriptionally inactive in resting monocytes, but was rapidly activated after TPA exposure.	Tetradecanoylphorbol Acetate	133-136	tumor necrosis factor	Homo sapiens	39-42
3366904-5	1988	The protein synthesis inhibitor, cycloheximide (CHX), had no detectable effect on levels of TNF transcripts in resting monocytes, while this agent superinduced the level of TNF mRNA by 50-fold in TPA-activated cells.	Tetradecanoylphorbol Acetate	196-199	tumor necrosis factor	Homo sapiens	173-176
3366904-10	1988	Run-on transcription assays performed on cells exposed to either TPA or the combination of TPA and CHX further indicated that CHX treatment increased transcription of the TNF gene.	Tetradecanoylphorbol Acetate	65-68	tumor necrosis factor	Homo sapiens	171-174
3366904-10	1988	Run-on transcription assays performed on cells exposed to either TPA or the combination of TPA and CHX further indicated that CHX treatment increased transcription of the TNF gene.	Tetradecanoylphorbol Acetate	91-94	tumor necrosis factor	Homo sapiens	171-174
3366904-11	1988	Thus, TNF gene expression is controlled at the transcriptional level in resting human monocytes, while both transcriptional and posttranscriptional events regulate the level of TNF transcripts in TPA-activated cells.	Tetradecanoylphorbol Acetate	196-199	tumor necrosis factor	Homo sapiens	177-180
2458497-9	1988	The amount of p60c-src protein decreased in some acute non-lymphoid leukemia cases, but it increased in others after TPA induced differentiation.	Tetradecanoylphorbol Acetate	117-120	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	19-22
3259133-8	1988	Likewise, TPA blocked this early PIP and PIP2 breakdown, but had no effect on the delayed breakdown of monophosphatidylinositol (PI).	Tetradecanoylphorbol Acetate	10-13	prolactin induced protein	Homo sapiens	33-36
3131868-4	1988	If AC or 12-O-tetradecanoyl-phorbol-13-acetate (TPA) were also present, IL-2 production and DNA synthesis were seen in both subsets.	Tetradecanoylphorbol Acetate	9-46	interleukin 2	Homo sapiens	72-76
3281943-8	1988	12-O-tetradecanoyl phorbol 13-acetate (TPA) also induced beta-actin mRNA, decreased angiotensinogen mRNA, and caused an increase in [3H]methyl thymidine incorporation.	Tetradecanoylphorbol Acetate	0-37	angiotensinogen	Rattus norvegicus	84-99
2833510-1	1988	This cytocidal activity of TNF was inhibited up to 90% in both cell lines after a 15-60-min pretreatment with 3-10 ng/ml of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	124-155	tumor necrosis factor	Homo sapiens	27-30
2833510-1	1988	This cytocidal activity of TNF was inhibited up to 90% in both cell lines after a 15-60-min pretreatment with 3-10 ng/ml of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	157-160	tumor necrosis factor	Homo sapiens	27-30
2833510-9	1988	Since OAG, PMA, and A23187 are all activators of protein kinase C (Ca2+/phospholipid-dependent enzyme), these results suggest that this kinase is involved in modulation of TNF sensitivity.	Tetradecanoylphorbol Acetate	11-14	tumor necrosis factor	Homo sapiens	172-175
2833510-10	1988	Furthermore, depletion or inhibition of protein kinase C antagonized PMA-induced effects on TNF cytotoxicity and binding to receptors.	Tetradecanoylphorbol Acetate	69-72	tumor necrosis factor	Homo sapiens	92-95
2833889-3	1988	AlF4-, a direct activator of GTP-binding proteins (G proteins), also induced the phospholipase C reactions and TPA inhibited the AlF4- -induced reactions.	Tetradecanoylphorbol Acetate	111-114	AF4/FMR2 family, member 4	Mus musculus	0-4
2833889-3	1988	AlF4-, a direct activator of GTP-binding proteins (G proteins), also induced the phospholipase C reactions and TPA inhibited the AlF4- -induced reactions.	Tetradecanoylphorbol Acetate	111-114	AF4/FMR2 family, member 4	Mus musculus	129-133
2835170-8	1988	Finally, progression to the proliferative phase of LGL, activated by TPA alone or with ionomycin, was completely abrogated by a hyperimmune anti-IL-2 antiserum.	Tetradecanoylphorbol Acetate	69-72	interleukin 2	Homo sapiens	145-149
3281943-8	1988	12-O-tetradecanoyl phorbol 13-acetate (TPA) also induced beta-actin mRNA, decreased angiotensinogen mRNA, and caused an increase in [3H]methyl thymidine incorporation.	Tetradecanoylphorbol Acetate	39-42	angiotensinogen	Rattus norvegicus	84-99
3162885-1	1988	Immunocytochemical methods were used to study protein kinase C (PKC) distribution in HL60 cells during the entire course of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation.	Tetradecanoylphorbol Acetate	124-160	proline rich transmembrane protein 2	Homo sapiens	46-62
3162885-1	1988	Immunocytochemical methods were used to study protein kinase C (PKC) distribution in HL60 cells during the entire course of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation.	Tetradecanoylphorbol Acetate	124-160	proline rich transmembrane protein 2	Homo sapiens	64-67
3162885-1	1988	Immunocytochemical methods were used to study protein kinase C (PKC) distribution in HL60 cells during the entire course of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation.	Tetradecanoylphorbol Acetate	162-165	proline rich transmembrane protein 2	Homo sapiens	46-62
3162885-1	1988	Immunocytochemical methods were used to study protein kinase C (PKC) distribution in HL60 cells during the entire course of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation.	Tetradecanoylphorbol Acetate	162-165	proline rich transmembrane protein 2	Homo sapiens	64-67
3134012-2	1988	Long-term exposure of hepatocytes to 4 beta-phorbol 12-myristate 13-acetate (TPA) resulted in a decrease in vasopressin or ATP inhibition of glycogen synthesis and glycogen synthase activity, without any change in the activation of glycogen phosphorylase.	Tetradecanoylphorbol Acetate	37-75	arginine vasopressin	Rattus norvegicus	108-119
3401441-1	1988	Stimulation of the macrophage-like cell line THP-1 with the phorbol ester phorbol 12-myristate 13-acetate (PMA) resulted in differentiation into cells with many features of macrophages.	Tetradecanoylphorbol Acetate	74-105	GLI family zinc finger 2	Homo sapiens	45-50
3401441-1	1988	Stimulation of the macrophage-like cell line THP-1 with the phorbol ester phorbol 12-myristate 13-acetate (PMA) resulted in differentiation into cells with many features of macrophages.	Tetradecanoylphorbol Acetate	107-110	GLI family zinc finger 2	Homo sapiens	45-50
3134012-2	1988	Long-term exposure of hepatocytes to 4 beta-phorbol 12-myristate 13-acetate (TPA) resulted in a decrease in vasopressin or ATP inhibition of glycogen synthesis and glycogen synthase activity, without any change in the activation of glycogen phosphorylase.	Tetradecanoylphorbol Acetate	77-80	arginine vasopressin	Rattus norvegicus	108-119
3134012-5	1988	The effects of TPA to decrease protein kinase C activity and to reverse the inactivation of glycogen synthase by vasopressin were well correlated and were mimicked by mezerein, but not by 4 alpha-phorbol.	Tetradecanoylphorbol Acetate	15-18	arginine vasopressin	Rattus norvegicus	113-124
3134012-6	1988	However, 1 microM-TPA totally inhibited protein kinase C activity, but reversed only 60% of the vasopressin effect on glycogen synthase.	Tetradecanoylphorbol Acetate	18-21	arginine vasopressin	Rattus norvegicus	96-107
3127039-1	1988	Endogenous diacylglycerol, as produced during ligand-stimulated hydrolysis of phosphatidylinositol, is a physiological activator of protein kinase C, a receptor for the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	184-220	promotion susceptibility QTL 1	Mus musculus	222-225
3162693-7	1988	Culture media of TPA-differentiated K562 cells also contained TGF-beta polypeptides as shown by a sensitive radioreceptor assay and by immunoprecipitation after metabolic labeling of the cells.	Tetradecanoylphorbol Acetate	17-20	transforming growth factor beta 1	Homo sapiens	62-70
2834235-3	1988	In addition, dbcAMP or PGE2 inhibited TPA-induced binding of PKC to plasma membrane, leading to decreased protein phosphorylation, and promoted subsequent redistribution of enzyme to the nuclear membrane region.	Tetradecanoylphorbol Acetate	38-41	proline rich transmembrane protein 2	Homo sapiens	61-64
2838419-5	1988	However, exposure of monocytes to recombinant IL 1 alpha or IL 1 beta resulted in enhanced generation of superoxide response following stimulation with PMA.	Tetradecanoylphorbol Acetate	152-155	interleukin 1 beta	Homo sapiens	60-69
3075462-7	1988	At the same time, macrophages harvested from treated MRL-lpr/lpr mice showed enhanced chemiluminescence triggered by phorbol-12-myristate-13-acetate (PMA) whereas peritoneal macrophages from treated normal mice did not.	Tetradecanoylphorbol Acetate	117-148	Fas (TNF receptor superfamily member 6)	Mus musculus	57-60
3075462-7	1988	At the same time, macrophages harvested from treated MRL-lpr/lpr mice showed enhanced chemiluminescence triggered by phorbol-12-myristate-13-acetate (PMA) whereas peritoneal macrophages from treated normal mice did not.	Tetradecanoylphorbol Acetate	117-148	Fas (TNF receptor superfamily member 6)	Mus musculus	61-64
3075462-7	1988	At the same time, macrophages harvested from treated MRL-lpr/lpr mice showed enhanced chemiluminescence triggered by phorbol-12-myristate-13-acetate (PMA) whereas peritoneal macrophages from treated normal mice did not.	Tetradecanoylphorbol Acetate	150-153	Fas (TNF receptor superfamily member 6)	Mus musculus	57-60
3075462-7	1988	At the same time, macrophages harvested from treated MRL-lpr/lpr mice showed enhanced chemiluminescence triggered by phorbol-12-myristate-13-acetate (PMA) whereas peritoneal macrophages from treated normal mice did not.	Tetradecanoylphorbol Acetate	150-153	Fas (TNF receptor superfamily member 6)	Mus musculus	61-64
3346564-4	1988	Neutrophils, from burn patients, stimulated with FMLP, phorbol myristate acetate, and calcium ionophore A23187 demonstrated a 51%, 37%, and 45% decrease, respectively, in release of immunoreactive fibronectin compared with control neutrophils.	Tetradecanoylphorbol Acetate	55-80	fibronectin 1	Homo sapiens	197-208
3132511-1	1988	A23187 in combination with phorbol myristate acetate (PMA) strongly induces production of interferon-gamma (IFN-gamma) by human peripheral blood mononuclear cells (PBMC) and even by murine PBMC, which respond poorly to A23187 alone.	Tetradecanoylphorbol Acetate	27-52	interferon gamma	Homo sapiens	90-106
3132511-1	1988	A23187 in combination with phorbol myristate acetate (PMA) strongly induces production of interferon-gamma (IFN-gamma) by human peripheral blood mononuclear cells (PBMC) and even by murine PBMC, which respond poorly to A23187 alone.	Tetradecanoylphorbol Acetate	27-52	interferon gamma	Homo sapiens	108-117
3132511-1	1988	A23187 in combination with phorbol myristate acetate (PMA) strongly induces production of interferon-gamma (IFN-gamma) by human peripheral blood mononuclear cells (PBMC) and even by murine PBMC, which respond poorly to A23187 alone.	Tetradecanoylphorbol Acetate	54-57	interferon gamma	Homo sapiens	90-106
3132511-1	1988	A23187 in combination with phorbol myristate acetate (PMA) strongly induces production of interferon-gamma (IFN-gamma) by human peripheral blood mononuclear cells (PBMC) and even by murine PBMC, which respond poorly to A23187 alone.	Tetradecanoylphorbol Acetate	54-57	interferon gamma	Homo sapiens	108-117
3141579-4	1988	The O2(-)-producing ability and chemiluminescence (CL) of host peritoneal M phi s in response to phorbol myristate acetate were markedly elevated by preinjection of PSK (1 or 5 mg per mouse intraperitoneally) around 4-7d before M phi-harvest.	Tetradecanoylphorbol Acetate	97-122	TAO kinase 2	Mus musculus	165-168
3128291-4	1988	Minor amounts of Ca2+/phospholipid-independent PK-C activity were found in the cytosol fraction at all times; they temporarily increased 2.5-fold with PMA and decreased after 1 h. Cyclosporin A did not affect the translocation of PK-C from the cytoplasm to the membrane fraction, but the decrease of PK-C activity following translocation was blocked.	Tetradecanoylphorbol Acetate	151-154	proline rich transmembrane protein 2	Homo sapiens	47-51
3260003-2	1988	Agents such as phorbol 12-myristate 13-acetate (PMA) that stimulate PKC augment the effects of antigen but are not sufficient for IL-2 activation.	Tetradecanoylphorbol Acetate	15-46	proline rich transmembrane protein 2	Homo sapiens	68-71
3260003-2	1988	Agents such as phorbol 12-myristate 13-acetate (PMA) that stimulate PKC augment the effects of antigen but are not sufficient for IL-2 activation.	Tetradecanoylphorbol Acetate	48-51	proline rich transmembrane protein 2	Homo sapiens	68-71
2451522-1	1988	Previous work from our laboratory demonstrated the mitogenic response of human peripheral blood T lymphocytes by phytohemagglutinin (PHA), phorbol myristate acetate (PMA) and ionomycin, or interleukin 2 (IL-2).	Tetradecanoylphorbol Acetate	166-169	interleukin 2	Homo sapiens	204-208
3267209-2	1988	The protein, designated erythroid differentiation factor (EDF), was found in the culture fluid of human THP-1 cells that had been treated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	143-174	inhibin subunit beta A	Homo sapiens	24-56
3267209-2	1988	The protein, designated erythroid differentiation factor (EDF), was found in the culture fluid of human THP-1 cells that had been treated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	143-174	inhibin subunit beta A	Homo sapiens	58-61
3267209-2	1988	The protein, designated erythroid differentiation factor (EDF), was found in the culture fluid of human THP-1 cells that had been treated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	143-174	GLI family zinc finger 2	Homo sapiens	104-109
3128291-1	1988	Stimulation of hepatocytes by the tumor promoter phorbol 12-myristate 13-acetate (PMA) caused translocation of cytosolic Ca2+/phospholipid-dependent protein kinase C (PK-C).	Tetradecanoylphorbol Acetate	49-80	proline rich transmembrane protein 2	Homo sapiens	149-165
3128291-1	1988	Stimulation of hepatocytes by the tumor promoter phorbol 12-myristate 13-acetate (PMA) caused translocation of cytosolic Ca2+/phospholipid-dependent protein kinase C (PK-C).	Tetradecanoylphorbol Acetate	49-80	proline rich transmembrane protein 2	Homo sapiens	167-171
3128291-1	1988	Stimulation of hepatocytes by the tumor promoter phorbol 12-myristate 13-acetate (PMA) caused translocation of cytosolic Ca2+/phospholipid-dependent protein kinase C (PK-C).	Tetradecanoylphorbol Acetate	82-85	proline rich transmembrane protein 2	Homo sapiens	149-165
3128291-1	1988	Stimulation of hepatocytes by the tumor promoter phorbol 12-myristate 13-acetate (PMA) caused translocation of cytosolic Ca2+/phospholipid-dependent protein kinase C (PK-C).	Tetradecanoylphorbol Acetate	82-85	proline rich transmembrane protein 2	Homo sapiens	167-171
2895607-8	1988	Because both the NTPase and mRNA efflux were inhibited by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate, the sensitive kinase is probably protein kinase C. Protein kinase C was found to be associated with the isolated nuclear envelope.	Tetradecanoylphorbol Acetate	78-114	inosine triphosphatase	Rattus norvegicus	17-23
2831864-7	1988	The phorbol ester 12-o-tetradecanoyl phorbol 13-acetate, a stimulator of protein kinase C, inhibited thrombin-induced generation of inositol phosphates, enhanced A23187-mediated prostacyclin production, and had complex effects on thrombin-mediated prostacyclin production, but had no effect on its production from extrinsic arachidonic acid.	Tetradecanoylphorbol Acetate	18-55	coagulation factor II, thrombin	Homo sapiens	101-109
2831864-7	1988	The phorbol ester 12-o-tetradecanoyl phorbol 13-acetate, a stimulator of protein kinase C, inhibited thrombin-induced generation of inositol phosphates, enhanced A23187-mediated prostacyclin production, and had complex effects on thrombin-mediated prostacyclin production, but had no effect on its production from extrinsic arachidonic acid.	Tetradecanoylphorbol Acetate	18-55	coagulation factor II, thrombin	Homo sapiens	230-238
2830903-5	1988	In the three SV-40-transformed variants examined, the diacylglycerol generative-response to TPA, serum and vasopressin, was greatly diminished or totally absent.	Tetradecanoylphorbol Acetate	92-95	arginine vasopressin	Rattus norvegicus	107-118
3278004-3	1988	We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18).	Tetradecanoylphorbol Acetate	14-39	integrin subunit beta 2	Homo sapiens	172-176
3355150-3	1988	After mono- or diphosphorylated 20-kDa MLC from thrombin-stimulated platelets was digested with trypsin, the analysis using two-dimensional peptide mapping demonstrated that two different sites were phosphorylated by MLC kinase and protein kinase C, as noted in the case of 12-O-tetradecanoylphorbol-13-acetate-stimulated platelets (M. Naka, et al.	Tetradecanoylphorbol Acetate	274-310	modulator of VRAC current 1	Homo sapiens	39-42
3355150-3	1988	After mono- or diphosphorylated 20-kDa MLC from thrombin-stimulated platelets was digested with trypsin, the analysis using two-dimensional peptide mapping demonstrated that two different sites were phosphorylated by MLC kinase and protein kinase C, as noted in the case of 12-O-tetradecanoylphorbol-13-acetate-stimulated platelets (M. Naka, et al.	Tetradecanoylphorbol Acetate	274-310	coagulation factor II, thrombin	Homo sapiens	48-56
2832316-2	1988	The lymphokine inhibited the locomotion of neutrophils and augmented the neutrophil oxygen-dependent respiratory burst in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) and phorbol myristate acetate (PMA), as measured by their capacity to produce chemiluminescence, H2O2 and superoxide.	Tetradecanoylphorbol Acetate	191-216	formyl peptide receptor 1	Homo sapiens	181-185
2832316-2	1988	The lymphokine inhibited the locomotion of neutrophils and augmented the neutrophil oxygen-dependent respiratory burst in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) and phorbol myristate acetate (PMA), as measured by their capacity to produce chemiluminescence, H2O2 and superoxide.	Tetradecanoylphorbol Acetate	218-221	formyl peptide receptor 1	Homo sapiens	181-185
2965212-0	1988	Production of tumor necrosis factor/cachectin by human T cell lines and peripheral blood T lymphocytes stimulated by phorbol myristate acetate and anti-CD3 antibody.	Tetradecanoylphorbol Acetate	117-142	tumor necrosis factor	Homo sapiens	36-45
3278004-3	1988	We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18).	Tetradecanoylphorbol Acetate	14-39	integrin subunit beta 2	Homo sapiens	247-251
2965212-12	1988	PMA was able to induce both TNF and LT mRNA syntheses.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	28-31
3127526-4	1988	When lymphocyte preparations were costimulated with PMA, the TSST-1 effect was strongly potentiated and the levels of cytotoxic factors, IFN-gamma, and IL-2 present in supernatant fluids were comparable to those observed after treatment with PMA and PHA.	Tetradecanoylphorbol Acetate	52-55	interferon gamma	Homo sapiens	137-146
3278004-3	1988	We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18).	Tetradecanoylphorbol Acetate	41-44	integrin subunit beta 2	Homo sapiens	172-176
3127526-4	1988	When lymphocyte preparations were costimulated with PMA, the TSST-1 effect was strongly potentiated and the levels of cytotoxic factors, IFN-gamma, and IL-2 present in supernatant fluids were comparable to those observed after treatment with PMA and PHA.	Tetradecanoylphorbol Acetate	52-55	interleukin 2	Homo sapiens	152-156
3278004-3	1988	We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18).	Tetradecanoylphorbol Acetate	41-44	integrin subunit beta 2	Homo sapiens	247-251
2831271-3	1988	However, THP-1, a monocytic cell line, could be infected by HCMV with a full cycle of replication after treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), which produced differentiation of the cell line into cells with characteristics of mature macrophages.	Tetradecanoylphorbol Acetate	119-156	GLI family zinc finger 2	Homo sapiens	9-14
2450126-1	1988	In the present study a unique antibody (NKI-L16) reacting with the alpha-chain of the human leukocyte function-associated Ag-1 (LFA-1) is described, which stimulates homotypic cell-cell interactions in a manner very similar to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in contrast to other anti-LFA-1 mAb which inhibit cell aggregation.	Tetradecanoylphorbol Acetate	227-264	Fc gamma receptor and transporter	Homo sapiens	67-78
2450126-1	1988	In the present study a unique antibody (NKI-L16) reacting with the alpha-chain of the human leukocyte function-associated Ag-1 (LFA-1) is described, which stimulates homotypic cell-cell interactions in a manner very similar to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in contrast to other anti-LFA-1 mAb which inhibit cell aggregation.	Tetradecanoylphorbol Acetate	266-269	Fc gamma receptor and transporter	Homo sapiens	67-78
2831271-3	1988	However, THP-1, a monocytic cell line, could be infected by HCMV with a full cycle of replication after treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), which produced differentiation of the cell line into cells with characteristics of mature macrophages.	Tetradecanoylphorbol Acetate	158-161	GLI family zinc finger 2	Homo sapiens	9-14
2897079-1	1988	Treatment of human adenocarcinoma MKN-7 cells with epidermal growth factor (EGF) or phorbol tetradecanoate acetate (TPA) stimulated phosphorylation of the c-erbB-2 gene product.	Tetradecanoylphorbol Acetate	116-119	erb-b2 receptor tyrosine kinase 2	Homo sapiens	155-163
3126369-5	1988	B-CLL cells could become responsive with the inclusion of the phorbol ester TPA (12-O-tetradecanoylphorbol-13-acetate) as co-stimulant such that half of the populations were now activated by IL4, particularly when BCGF was also present.	Tetradecanoylphorbol Acetate	76-79	interleukin 4	Homo sapiens	191-194
3126369-5	1988	B-CLL cells could become responsive with the inclusion of the phorbol ester TPA (12-O-tetradecanoylphorbol-13-acetate) as co-stimulant such that half of the populations were now activated by IL4, particularly when BCGF was also present.	Tetradecanoylphorbol Acetate	81-117	interleukin 4	Homo sapiens	191-194
2897079-4	1988	Tryptic phosphopeptide mapping analysis suggested that treatments with EGF and TPA induced phosphorylation of many common sites in the c-erbB-2 gene product.	Tetradecanoylphorbol Acetate	79-82	erb-b2 receptor tyrosine kinase 2	Homo sapiens	135-143
2897079-5	1988	However, in contrast to TPA, EGF increased the phosphorylation of the c-erbB-2 protein in cells whose protein kinase C had been down-regulated by long-term pretreatment with TPA, suggesting that EGF and TPA induce phosphorylation by different mechanisms.	Tetradecanoylphorbol Acetate	174-177	erb-b2 receptor tyrosine kinase 2	Homo sapiens	70-78
2897079-5	1988	However, in contrast to TPA, EGF increased the phosphorylation of the c-erbB-2 protein in cells whose protein kinase C had been down-regulated by long-term pretreatment with TPA, suggesting that EGF and TPA induce phosphorylation by different mechanisms.	Tetradecanoylphorbol Acetate	174-177	erb-b2 receptor tyrosine kinase 2	Homo sapiens	70-78
3342259-3	1988	Administration of cycloheximide, phenoxybenzamine, phorbol 12-myristate 13-acetate, nifedipine, dexamethasone or indomethacin to partially hepatectomized rats prevented the synthesis of thymidylate synthetase in regenerating liver.	Tetradecanoylphorbol Acetate	51-82	thymidylate synthetase	Rattus norvegicus	186-208
3123493-4	1988	Phorbol 12-myristate 13-acetate (PMA) induced IL 2 receptor expression on II23 cells but not IL 2 secretion.	Tetradecanoylphorbol Acetate	0-31	interleukin 2	Homo sapiens	46-50
3123493-4	1988	Phorbol 12-myristate 13-acetate (PMA) induced IL 2 receptor expression on II23 cells but not IL 2 secretion.	Tetradecanoylphorbol Acetate	33-36	interleukin 2	Homo sapiens	46-50
2448308-8	1988	The ability of IBMX to inhibit CTL activation when the TcR cross-linking step was by-passed by the combination of phorbol myristate acetate and ionophore A23187 suggests that the locus of inhibitory effect of cAMP is at both the early and late stages of the TcR-triggered transmembrane signaling pathway.	Tetradecanoylphorbol Acetate	114-139	cathelicidin antimicrobial peptide	Homo sapiens	209-213
3278921-5	1988	Down regulation of PKC activity by treatment with TPA for 48-h blocks the stimulation of S6 kinase by TPA but leaves the activation by EGF, IGF-I and insulin unaffected.	Tetradecanoylphorbol Acetate	50-53	insulin like growth factor 1	Homo sapiens	140-145
3276673-2	1988	Both insulin and the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) induced c-fos mRNA accumulation in cells expressing high numbers of normal human insulin receptors; PMA but not insulin was effective in the cells expressing the mutant receptor.	Tetradecanoylphorbol Acetate	51-82	insulin	Cricetulus griseus	170-177
2962643-1	1988	A one-chain recombinant tissue-type plasminogen activator (EC 2.4.31.-) (tPA) analogue was constructed in which Arg-275 of the activation site was changed to Gly by site-directed mutagenesis.	Tetradecanoylphorbol Acetate	73-76	plasminogen activator, tissue type	Homo sapiens	24-57
3276673-2	1988	Both insulin and the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) induced c-fos mRNA accumulation in cells expressing high numbers of normal human insulin receptors; PMA but not insulin was effective in the cells expressing the mutant receptor.	Tetradecanoylphorbol Acetate	51-82	insulin	Homo sapiens	170-177
3276673-2	1988	Both insulin and the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) induced c-fos mRNA accumulation in cells expressing high numbers of normal human insulin receptors; PMA but not insulin was effective in the cells expressing the mutant receptor.	Tetradecanoylphorbol Acetate	84-87	insulin	Cricetulus griseus	170-177
3276673-2	1988	Both insulin and the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) induced c-fos mRNA accumulation in cells expressing high numbers of normal human insulin receptors; PMA but not insulin was effective in the cells expressing the mutant receptor.	Tetradecanoylphorbol Acetate	84-87	insulin	Homo sapiens	170-177
2827903-2	1988	The time courses for specific inhibition by CuZn-superoxide dismutase (CuZn-SOD) of the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of neoplastic transformation in JB6 cells and for changes in antioxidant enzyme activities associated with TPA-exposure were examined.	Tetradecanoylphorbol Acetate	88-124	superoxide dismutase 1	Homo sapiens	44-69
3257396-10	1988	HH1 (CD37) was expressed by the majority of the cells before TPA treatment and decreased to almost undetectable levels within 24 hours.	Tetradecanoylphorbol Acetate	61-64	anosmin 1	Homo sapiens	0-3
2448059-8	1988	Angiotensin II enhances the phosphorylation state of the same set of proteins as observed with TPA.	Tetradecanoylphorbol Acetate	95-98	angiotensinogen	Rattus norvegicus	0-14
2448059-10	1988	The remarkable similarity in mechanical, electrical, and protein phosphorylation responses of cultured neonatal myocytes following TPA or angiotensin II application indicate that protein kinase C may mediate the action of angiotensin II.	Tetradecanoylphorbol Acetate	131-134	angiotensinogen	Rattus norvegicus	222-236
2827903-2	1988	The time courses for specific inhibition by CuZn-superoxide dismutase (CuZn-SOD) of the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of neoplastic transformation in JB6 cells and for changes in antioxidant enzyme activities associated with TPA-exposure were examined.	Tetradecanoylphorbol Acetate	88-124	superoxide dismutase 1	Homo sapiens	71-79
2827897-4	1988	U937 cells cultured with 1 ng/ml phorbol myristate acetate (PMA) for 4 days (PMA-U937 cells) lost the ability to respond to LTB4, although they responded to fMLP.	Tetradecanoylphorbol Acetate	33-58	formyl peptide receptor 1	Homo sapiens	157-161
2827903-2	1988	The time courses for specific inhibition by CuZn-superoxide dismutase (CuZn-SOD) of the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of neoplastic transformation in JB6 cells and for changes in antioxidant enzyme activities associated with TPA-exposure were examined.	Tetradecanoylphorbol Acetate	126-129	superoxide dismutase 1	Homo sapiens	44-69
2827897-4	1988	U937 cells cultured with 1 ng/ml phorbol myristate acetate (PMA) for 4 days (PMA-U937 cells) lost the ability to respond to LTB4, although they responded to fMLP.	Tetradecanoylphorbol Acetate	60-63	formyl peptide receptor 1	Homo sapiens	157-161
2827903-2	1988	The time courses for specific inhibition by CuZn-superoxide dismutase (CuZn-SOD) of the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of neoplastic transformation in JB6 cells and for changes in antioxidant enzyme activities associated with TPA-exposure were examined.	Tetradecanoylphorbol Acetate	126-129	superoxide dismutase 1	Homo sapiens	71-79
2827903-2	1988	The time courses for specific inhibition by CuZn-superoxide dismutase (CuZn-SOD) of the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of neoplastic transformation in JB6 cells and for changes in antioxidant enzyme activities associated with TPA-exposure were examined.	Tetradecanoylphorbol Acetate	256-259	superoxide dismutase 1	Homo sapiens	44-69
2827903-2	1988	The time courses for specific inhibition by CuZn-superoxide dismutase (CuZn-SOD) of the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced promotion of neoplastic transformation in JB6 cells and for changes in antioxidant enzyme activities associated with TPA-exposure were examined.	Tetradecanoylphorbol Acetate	256-259	superoxide dismutase 1	Homo sapiens	71-79
3123109-2	1988	In the neutrophil, the surface expression of the CD11/CD18 complex is up-modulated (Mo1 greater than p150,95 much greater than LFA-1) by stimulatory factors that include calcium ionophore A23187, phorbol myristate acetate (PMA), and N-L-formyl-L-leucyl-L-phenylalanine (fMLP).	Tetradecanoylphorbol Acetate	196-221	integrin subunit beta 2	Homo sapiens	54-58
3123109-2	1988	In the neutrophil, the surface expression of the CD11/CD18 complex is up-modulated (Mo1 greater than p150,95 much greater than LFA-1) by stimulatory factors that include calcium ionophore A23187, phorbol myristate acetate (PMA), and N-L-formyl-L-leucyl-L-phenylalanine (fMLP).	Tetradecanoylphorbol Acetate	223-226	integrin subunit beta 2	Homo sapiens	54-58
2827903-3	1988	The antipromoting effect of CuZn-SOD was found to be critically dependent on the time of addition of CuZn-SOD relative to the start of a 14-day exposure of cells to TPA.	Tetradecanoylphorbol Acetate	165-168	superoxide dismutase 1	Homo sapiens	28-36
2827903-4	1988	Treatment of JB6 P+ Clone 22 and Clone 41 cells with CuZn-SOD for 18 h before, simultaneously with or up to 1 h after exposure to TPA, all inhibited promotion of transformation maximally.	Tetradecanoylphorbol Acetate	130-133	superoxide dismutase 1	Homo sapiens	53-61
2827903-5	1988	Delay of addition of CuZn-SOD by 2 h or more after the start of TPA treatment resulted in a marked decrease in the promotion inhibitory effect.	Tetradecanoylphorbol Acetate	64-67	superoxide dismutase 1	Homo sapiens	21-29
2827903-9	1988	Upon TPA exposure, JB6 Clone 41 cells exhibited time-specific activity changes in the cellular SOD, glutathione peroxidase (GSH-Px), and catalase.	Tetradecanoylphorbol Acetate	5-8	superoxide dismutase 1	Homo sapiens	95-98
2827903-9	1988	Upon TPA exposure, JB6 Clone 41 cells exhibited time-specific activity changes in the cellular SOD, glutathione peroxidase (GSH-Px), and catalase.	Tetradecanoylphorbol Acetate	5-8	catalase	Homo sapiens	137-145
2827903-10	1988	SOD and GSH-Px activities were reduced to 54% and 26% respectively of basal levels within 2 h of TPA treatment.	Tetradecanoylphorbol Acetate	97-100	superoxide dismutase 1	Homo sapiens	0-3
2448126-3	1988	Treatment with phorbol-12-myristate-13-acetate (PMA) resulted in a dose-dependent increase in the secretion of both CT and CgA by the two cell lines.	Tetradecanoylphorbol Acetate	15-46	chromogranin A	Homo sapiens	123-126
2827903-11	1988	GSH-Px activity recovered to basal levels within 4 h and CuZn-SOD within 48 h. Catalase activity was maximally reduced to 50% of basal within 1 h after TPA treatment and rebounded to greater than basal levels within 4 h. It is postulated that a c-kinase-dependent event induces rapid elevation of superoxide anion following TPA exposure and that this leads to reduced activity of antioxidant enzymes.	Tetradecanoylphorbol Acetate	152-155	superoxide dismutase 1	Homo sapiens	57-65
2448126-3	1988	Treatment with phorbol-12-myristate-13-acetate (PMA) resulted in a dose-dependent increase in the secretion of both CT and CgA by the two cell lines.	Tetradecanoylphorbol Acetate	48-51	chromogranin A	Homo sapiens	123-126
2827903-11	1988	GSH-Px activity recovered to basal levels within 4 h and CuZn-SOD within 48 h. Catalase activity was maximally reduced to 50% of basal within 1 h after TPA treatment and rebounded to greater than basal levels within 4 h. It is postulated that a c-kinase-dependent event induces rapid elevation of superoxide anion following TPA exposure and that this leads to reduced activity of antioxidant enzymes.	Tetradecanoylphorbol Acetate	152-155	catalase	Homo sapiens	79-87
2827903-11	1988	GSH-Px activity recovered to basal levels within 4 h and CuZn-SOD within 48 h. Catalase activity was maximally reduced to 50% of basal within 1 h after TPA treatment and rebounded to greater than basal levels within 4 h. It is postulated that a c-kinase-dependent event induces rapid elevation of superoxide anion following TPA exposure and that this leads to reduced activity of antioxidant enzymes.	Tetradecanoylphorbol Acetate	324-327	catalase	Homo sapiens	79-87
2827903-12	1988	Since antipromotion by exogenous CuZn-SOD is effective only during the first 2 h following TPA exposure, this suggests that the promotion-relevant 0.2- elevation is transient.	Tetradecanoylphorbol Acetate	91-94	superoxide dismutase 1	Homo sapiens	33-41
3124825-2	1988	Human growth hormone (hGH) and rat IL-2 stimulated Nb2-cell proliferation to approximately the same degree, and the actions of both mitogens were potentiated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	194-197	growth hormone 1	Homo sapiens	6-20
3346341-1	1988	The identity of the genetic defect(s) in Swiss 3T3 TNR-2 and TNR-9 that confers nonresponsiveness to the proliferative effect of 12-0-tetradecanoylphorbol-13-acetate (TPA) is not known.	Tetradecanoylphorbol Acetate	167-170	tenascin R	Mus musculus	51-54
3346341-1	1988	The identity of the genetic defect(s) in Swiss 3T3 TNR-2 and TNR-9 that confers nonresponsiveness to the proliferative effect of 12-0-tetradecanoylphorbol-13-acetate (TPA) is not known.	Tetradecanoylphorbol Acetate	167-170	tenascin R	Mus musculus	61-64
3346341-4	1988	When the rate of 86Rb+ efflux (as a tracer for K+) was measured from each of the three cell lines, a furosemide- and TPA-inhibitable component of efflux was clearly evident in parental and TNR-9 cells but was virtually absent in TNR-2 cells.	Tetradecanoylphorbol Acetate	117-120	tenascin R	Mus musculus	189-192
3346341-4	1988	When the rate of 86Rb+ efflux (as a tracer for K+) was measured from each of the three cell lines, a furosemide- and TPA-inhibitable component of efflux was clearly evident in parental and TNR-9 cells but was virtually absent in TNR-2 cells.	Tetradecanoylphorbol Acetate	117-120	tenascin R	Mus musculus	229-232
3346341-5	1988	86Rb+ influx measurements indicated the presence in parental 3T3 cells and the TNR-9 line of a substantial furosemide-sensitive flux that could be inhibited by TPA.	Tetradecanoylphorbol Acetate	160-163	tenascin R	Mus musculus	79-82
3346341-11	1988	In contrast, because of the reduced level of cotransport activity in TNR-2 cells, TPA had only a slight effect on cell volume.	Tetradecanoylphorbol Acetate	82-85	tenascin R	Mus musculus	69-72
3277184-4	1988	In the present work, we have studied the interaction of insulin and phorbol 12-myristate 13-acetate (PMA), a documented activator of protein kinase C. Preincubation of skins with 1,2-dioctanoylglycerol, another activator of protein kinase C, increases baseline Na+ transport and reduces the subsequent natriferic response to PMA.	Tetradecanoylphorbol Acetate	68-99	insulin	Homo sapiens	56-63
3277184-4	1988	In the present work, we have studied the interaction of insulin and phorbol 12-myristate 13-acetate (PMA), a documented activator of protein kinase C. Preincubation of skins with 1,2-dioctanoylglycerol, another activator of protein kinase C, increases baseline Na+ transport and reduces the subsequent natriferic response to PMA.	Tetradecanoylphorbol Acetate	101-104	insulin	Homo sapiens	56-63
3277184-5	1988	Preincubation with PMA markedly reduces the subsequent natriferic action of insulin.	Tetradecanoylphorbol Acetate	19-22	insulin	Homo sapiens	76-83
3277184-6	1988	This effect does not appear to primarily reflect PMA-induced internalization of insulin receptors.	Tetradecanoylphorbol Acetate	49-52	insulin	Homo sapiens	80-87
3126303-4	1988	The combination of A23187 and TPA significantly (p less than 0.005-0.001) enhanced IL2 secretion in patients" cell cultures (range, 20 to greater than 64 U/ml).	Tetradecanoylphorbol Acetate	30-33	interleukin 2	Homo sapiens	83-86
2968003-0	1988	Induction of the CD4-8+ suppressor phenotype in CD4+8+ human thymocytes by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	75-100	CD4 molecule	Homo sapiens	17-20
2968003-5	1988	After treatment of the CD4+8+ cells in both PNA+ and PNA- fractions for 20 hr with phorbol 12-myristate 13-acetate (PMA), 60%-90% of the cells expressed the CD4-8+ phenotype, whereas the CD4+8+ phenotype was decreased to 1%-3% of the population.	Tetradecanoylphorbol Acetate	83-114	CD4 molecule	Homo sapiens	23-26
2968003-5	1988	After treatment of the CD4+8+ cells in both PNA+ and PNA- fractions for 20 hr with phorbol 12-myristate 13-acetate (PMA), 60%-90% of the cells expressed the CD4-8+ phenotype, whereas the CD4+8+ phenotype was decreased to 1%-3% of the population.	Tetradecanoylphorbol Acetate	83-114	CD4 molecule	Homo sapiens	157-160
2968003-5	1988	After treatment of the CD4+8+ cells in both PNA+ and PNA- fractions for 20 hr with phorbol 12-myristate 13-acetate (PMA), 60%-90% of the cells expressed the CD4-8+ phenotype, whereas the CD4+8+ phenotype was decreased to 1%-3% of the population.	Tetradecanoylphorbol Acetate	83-114	CD4 molecule	Homo sapiens	157-160
2968003-5	1988	After treatment of the CD4+8+ cells in both PNA+ and PNA- fractions for 20 hr with phorbol 12-myristate 13-acetate (PMA), 60%-90% of the cells expressed the CD4-8+ phenotype, whereas the CD4+8+ phenotype was decreased to 1%-3% of the population.	Tetradecanoylphorbol Acetate	116-119	CD4 molecule	Homo sapiens	23-26
2968003-5	1988	After treatment of the CD4+8+ cells in both PNA+ and PNA- fractions for 20 hr with phorbol 12-myristate 13-acetate (PMA), 60%-90% of the cells expressed the CD4-8+ phenotype, whereas the CD4+8+ phenotype was decreased to 1%-3% of the population.	Tetradecanoylphorbol Acetate	116-119	CD4 molecule	Homo sapiens	157-160
2968003-5	1988	After treatment of the CD4+8+ cells in both PNA+ and PNA- fractions for 20 hr with phorbol 12-myristate 13-acetate (PMA), 60%-90% of the cells expressed the CD4-8+ phenotype, whereas the CD4+8+ phenotype was decreased to 1%-3% of the population.	Tetradecanoylphorbol Acetate	116-119	CD4 molecule	Homo sapiens	157-160
3122755-5	1988	When IL1 was added together with human recombinant interferon-gamma (IFN-gamma), the resulting Fru-2,6-P2 level was synergistically increased, whilst the combination of IFN-gamma and TPA produced only an additive increase.	Tetradecanoylphorbol Acetate	183-186	interferon gamma	Homo sapiens	51-67
3122755-5	1988	When IL1 was added together with human recombinant interferon-gamma (IFN-gamma), the resulting Fru-2,6-P2 level was synergistically increased, whilst the combination of IFN-gamma and TPA produced only an additive increase.	Tetradecanoylphorbol Acetate	183-186	interferon gamma	Homo sapiens	69-78
3122759-1	1988	Human peripheral blood lymphocytes secrete high titers of interleukin-2 (IL-2) after stimulation by Ca2+-ionophore A23187/phorbol 12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	122-153	interleukin 2	Homo sapiens	58-71
3122759-1	1988	Human peripheral blood lymphocytes secrete high titers of interleukin-2 (IL-2) after stimulation by Ca2+-ionophore A23187/phorbol 12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	122-153	interleukin 2	Homo sapiens	73-77
3128036-1	1988	Expression of the leukemia-associated cell surface antigen p24 (CD9) on human hematopoietic cell lines and B-cell chronic lymphocytic leukemia (B-CLL) cells was analyzed before and after treatment with the phorbol ester 12-o-tetradecanoyl-phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	220-257	transmembrane p24 trafficking protein 2	Homo sapiens	59-62
3128036-1	1988	Expression of the leukemia-associated cell surface antigen p24 (CD9) on human hematopoietic cell lines and B-cell chronic lymphocytic leukemia (B-CLL) cells was analyzed before and after treatment with the phorbol ester 12-o-tetradecanoyl-phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	259-262	transmembrane p24 trafficking protein 2	Homo sapiens	59-62
3250229-13	1988	Our data indicate that the stimulation of glycogenolysis in the liver by PMA is mediated by non-parenchymal cells which produce PGD2 in response to PMA, leading subsequently to activation of the phosphorylase system in the parenchymal cells.	Tetradecanoylphorbol Acetate	73-76	prostaglandin D2 synthase	Homo sapiens	128-132
3146199-1	1988	4 beta-Phorbol-12-myristate-13-acetate (PMA) at 100 ng/ml was able to induce platelet aggregation in the presence of agents which inhibited aggregation, triggered by other agonists such as adenosine diphosphate sodium salt (ADP), thrombin and collagen.	Tetradecanoylphorbol Acetate	0-38	coagulation factor II, thrombin	Homo sapiens	230-238
3146199-1	1988	4 beta-Phorbol-12-myristate-13-acetate (PMA) at 100 ng/ml was able to induce platelet aggregation in the presence of agents which inhibited aggregation, triggered by other agonists such as adenosine diphosphate sodium salt (ADP), thrombin and collagen.	Tetradecanoylphorbol Acetate	40-43	coagulation factor II, thrombin	Homo sapiens	230-238
3250229-13	1988	Our data indicate that the stimulation of glycogenolysis in the liver by PMA is mediated by non-parenchymal cells which produce PGD2 in response to PMA, leading subsequently to activation of the phosphorylase system in the parenchymal cells.	Tetradecanoylphorbol Acetate	148-151	prostaglandin D2 synthase	Homo sapiens	128-132
2839091-1	1988	We have previously shown that the VIP precursor contains a novel PHI-27-like peptide, PHM-27, and that the synthesis of the prepro-VIP/PHM-27 mRNA is induced with cAMP and TPA in human neuroblastoma cells.	Tetradecanoylphorbol Acetate	172-175	vasoactive intestinal peptide	Homo sapiens	34-37
2839091-1	1988	We have previously shown that the VIP precursor contains a novel PHI-27-like peptide, PHM-27, and that the synthesis of the prepro-VIP/PHM-27 mRNA is induced with cAMP and TPA in human neuroblastoma cells.	Tetradecanoylphorbol Acetate	172-175	vasoactive intestinal peptide	Homo sapiens	124-134
2839091-1	1988	We have previously shown that the VIP precursor contains a novel PHI-27-like peptide, PHM-27, and that the synthesis of the prepro-VIP/PHM-27 mRNA is induced with cAMP and TPA in human neuroblastoma cells.	Tetradecanoylphorbol Acetate	172-175	vasoactive intestinal peptide	Homo sapiens	135-141
3257464-4	1988	IL-2 suppressed the stimulatory effects of both the chemotactic peptide formyl-methionyl-leucyl-phenyl-alanine (FMLP) and the phorbol ester phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	140-165	interleukin 2	Homo sapiens	0-4
2844520-3	1988	TPA induced ACTH release in a dose dependent fashion with an ED50 of 4.2 x 10(-10) M. The maximal amount of ACTH release individually induced by TPA (10(-8) M) and CRH (10(-8)) were identical.	Tetradecanoylphorbol Acetate	0-3	corticotropin releasing hormone	Rattus norvegicus	164-167
2844520-4	1988	TPA (10(-8)) potentiated the amount of ACTH release from cells already maximally stimulated with CRH (4 x 10(-8) M).	Tetradecanoylphorbol Acetate	0-3	corticotropin releasing hormone	Rattus norvegicus	97-100
2844520-6	1988	Cortisol decreased the amount of ACTH individually released by TPA and CRH in a similar and dose dependent fashion with maximal inhibition of 47% occurring at 10(-7) M. PGE2 caused a dose dependent reduction of TPA mediated ACTH release.	Tetradecanoylphorbol Acetate	211-214	corticotropin releasing hormone	Rattus norvegicus	71-74
3069641-12	1988	Short-term (less than 1 h) treatment of endothelial cells with the perturbing phorbol ester 4 beta-phorbol-12-myristate-13-acetate (PMA) results in release of cellular stored von Willebrand factor.	Tetradecanoylphorbol Acetate	94-130	von Willebrand factor	Homo sapiens	175-196
3069641-12	1988	Short-term (less than 1 h) treatment of endothelial cells with the perturbing phorbol ester 4 beta-phorbol-12-myristate-13-acetate (PMA) results in release of cellular stored von Willebrand factor.	Tetradecanoylphorbol Acetate	132-135	von Willebrand factor	Homo sapiens	175-196
3069641-13	1988	24-48 h after exposure to PMA the endothelial cell distribution of von Willebrand factor is changed distinctly.	Tetradecanoylphorbol Acetate	26-29	von Willebrand factor	Homo sapiens	67-88
3191296-5	1988	Our results show that 4-beta-phorbol-12-myristate-13-acetate decreased intracellular AChRs and suppressed AChR synthesis without affecting the turnover rate.	Tetradecanoylphorbol Acetate	22-60	cholinergic receptor nicotinic delta subunit	Gallus gallus	85-89
2837335-3	1988	Addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to neutrophil preparations (70 +/- 5% ring neutrophils and metamyelocytes) elicited superoxide anion generation, as indicated by superoxide dismutase (SOD)-inhibitable acetylated cytochrome c reduction, and oxidant-dependent chemiluminescence (CL) from luminol or lucigenin.	Tetradecanoylphorbol Acetate	30-66	superoxide dismutase 1	Homo sapiens	202-222
2837335-3	1988	Addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to neutrophil preparations (70 +/- 5% ring neutrophils and metamyelocytes) elicited superoxide anion generation, as indicated by superoxide dismutase (SOD)-inhibitable acetylated cytochrome c reduction, and oxidant-dependent chemiluminescence (CL) from luminol or lucigenin.	Tetradecanoylphorbol Acetate	30-66	superoxide dismutase 1	Homo sapiens	224-227
2837335-3	1988	Addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to neutrophil preparations (70 +/- 5% ring neutrophils and metamyelocytes) elicited superoxide anion generation, as indicated by superoxide dismutase (SOD)-inhibitable acetylated cytochrome c reduction, and oxidant-dependent chemiluminescence (CL) from luminol or lucigenin.	Tetradecanoylphorbol Acetate	30-66	cytochrome c, somatic	Homo sapiens	252-264
2837335-3	1988	Addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to neutrophil preparations (70 +/- 5% ring neutrophils and metamyelocytes) elicited superoxide anion generation, as indicated by superoxide dismutase (SOD)-inhibitable acetylated cytochrome c reduction, and oxidant-dependent chemiluminescence (CL) from luminol or lucigenin.	Tetradecanoylphorbol Acetate	68-71	superoxide dismutase 1	Homo sapiens	202-222
2837335-3	1988	Addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to neutrophil preparations (70 +/- 5% ring neutrophils and metamyelocytes) elicited superoxide anion generation, as indicated by superoxide dismutase (SOD)-inhibitable acetylated cytochrome c reduction, and oxidant-dependent chemiluminescence (CL) from luminol or lucigenin.	Tetradecanoylphorbol Acetate	68-71	superoxide dismutase 1	Homo sapiens	224-227
2837335-3	1988	Addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to neutrophil preparations (70 +/- 5% ring neutrophils and metamyelocytes) elicited superoxide anion generation, as indicated by superoxide dismutase (SOD)-inhibitable acetylated cytochrome c reduction, and oxidant-dependent chemiluminescence (CL) from luminol or lucigenin.	Tetradecanoylphorbol Acetate	68-71	cytochrome c, somatic	Homo sapiens	252-264
3257464-4	1988	IL-2 suppressed the stimulatory effects of both the chemotactic peptide formyl-methionyl-leucyl-phenyl-alanine (FMLP) and the phorbol ester phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	167-170	interleukin 2	Homo sapiens	0-4
2826588-6	1988	Fluoride ions were found to be as effective as tetradecanoyl phorbol acetate to stimulate IL-2 synthesis in Jurkat cells when used in combination with phytohemagglutinin.	Tetradecanoylphorbol Acetate	47-76	interleukin 2	Homo sapiens	90-94
3057191-7	1988	A high endogenous level of in vivo phosphorylation of threonine 654 of the EGF receptor was found in MDA-MB-231 cells and treatment of cells with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) further stimulated phosphorylation of this residue.	Tetradecanoylphorbol Acetate	146-183	epidermal growth factor receptor	Homo sapiens	75-87
2845113-3	1988	In contrast, PMA enhanced the cyclic AMP response to vasoactive intestinal peptide (VIP) and forskolin in cerebral cortical and diencephalic cells, whereas 4 alpha-PDD was inactive.	Tetradecanoylphorbol Acetate	13-16	vasoactive intestinal peptide	Rattus norvegicus	84-87
3057191-7	1988	A high endogenous level of in vivo phosphorylation of threonine 654 of the EGF receptor was found in MDA-MB-231 cells and treatment of cells with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) further stimulated phosphorylation of this residue.	Tetradecanoylphorbol Acetate	185-188	epidermal growth factor receptor	Homo sapiens	75-87
2835720-2	1988	Treatment of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) caused a decrease in the cytosolic PK-C with a concomitant increase in PK-C recovered in the membrane fraction.	Tetradecanoylphorbol Acetate	28-64	proline rich transmembrane protein 2	Homo sapiens	106-110
3259277-12	1988	Moreover, when the cells were pre-activated with SAC or with PHA plus TPA and then further stimulated with IL-2, a 2-20 fold increase in proliferative response was found in the majority of cases studied.	Tetradecanoylphorbol Acetate	70-73	interleukin 2	Homo sapiens	107-111
3261032-0	1988	Phorbol myristate acetate (PMA) reverses inhibition of interleukin-2 production by T lymphocytes of patients with systemic lupus erythematosus.	Tetradecanoylphorbol Acetate	0-25	interleukin 2	Homo sapiens	55-68
3261032-0	1988	Phorbol myristate acetate (PMA) reverses inhibition of interleukin-2 production by T lymphocytes of patients with systemic lupus erythematosus.	Tetradecanoylphorbol Acetate	27-30	interleukin 2	Homo sapiens	55-68
3261032-3	1988	The depressed IL-2 production by SLE T cells was largely reversed by the addition of phorbol myristate acetate (PMA), which directly activates protein kinase C. This can explain why some authors using PMA together with mitogens were not able to find a depressed IL-2 production in SLE patients.	Tetradecanoylphorbol Acetate	85-110	interleukin 2	Homo sapiens	14-18
3261032-3	1988	The depressed IL-2 production by SLE T cells was largely reversed by the addition of phorbol myristate acetate (PMA), which directly activates protein kinase C. This can explain why some authors using PMA together with mitogens were not able to find a depressed IL-2 production in SLE patients.	Tetradecanoylphorbol Acetate	85-110	interleukin 2	Homo sapiens	262-266
3261032-3	1988	The depressed IL-2 production by SLE T cells was largely reversed by the addition of phorbol myristate acetate (PMA), which directly activates protein kinase C. This can explain why some authors using PMA together with mitogens were not able to find a depressed IL-2 production in SLE patients.	Tetradecanoylphorbol Acetate	112-115	interleukin 2	Homo sapiens	14-18
3261032-3	1988	The depressed IL-2 production by SLE T cells was largely reversed by the addition of phorbol myristate acetate (PMA), which directly activates protein kinase C. This can explain why some authors using PMA together with mitogens were not able to find a depressed IL-2 production in SLE patients.	Tetradecanoylphorbol Acetate	112-115	interleukin 2	Homo sapiens	262-266
19651096-3	1988	By adding back 10% FCS or phorbol-12-myristate-13-acetate (PMA) at 1 micro/ml concentrations the rate of [(3)H]thymidine incorporation was increased while both bradykinin and vasopressin had no effect on the rate of [(3)H]thymidine incorporation into astrocytes.	Tetradecanoylphorbol Acetate	59-62	arginine vasopressin	Rattus norvegicus	175-186
2835720-2	1988	Treatment of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) caused a decrease in the cytosolic PK-C with a concomitant increase in PK-C recovered in the membrane fraction.	Tetradecanoylphorbol Acetate	28-64	proline rich transmembrane protein 2	Homo sapiens	142-146
2835720-2	1988	Treatment of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) caused a decrease in the cytosolic PK-C with a concomitant increase in PK-C recovered in the membrane fraction.	Tetradecanoylphorbol Acetate	66-69	proline rich transmembrane protein 2	Homo sapiens	106-110
2835720-2	1988	Treatment of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) caused a decrease in the cytosolic PK-C with a concomitant increase in PK-C recovered in the membrane fraction.	Tetradecanoylphorbol Acetate	66-69	proline rich transmembrane protein 2	Homo sapiens	142-146
3065776-5	1988	Activators of protein kinase C, 1.3 microM 12-O-tetradecanoylphorbol-13-acetate (TPA) and 25.1 microM 1-oleoyl-2-acetylglycerol, caused significant release of insulin from cultured explants of human fetal pancreas.	Tetradecanoylphorbol Acetate	43-79	insulin	Homo sapiens	159-166
2835720-4	1988	PK-C activity in the cytosolic fraction could be stimulated by TPA without the addition of phosphatidylserine and diacylglycerol.	Tetradecanoylphorbol Acetate	63-66	proline rich transmembrane protein 2	Homo sapiens	0-4
3065776-5	1988	Activators of protein kinase C, 1.3 microM 12-O-tetradecanoylphorbol-13-acetate (TPA) and 25.1 microM 1-oleoyl-2-acetylglycerol, caused significant release of insulin from cultured explants of human fetal pancreas.	Tetradecanoylphorbol Acetate	81-84	insulin	Homo sapiens	159-166
3065776-9	1988	However, when the concentration of glucose was increased to 20 or 30 mM, stimulation of insulin secretion returned to levels achieved with TPA alone.	Tetradecanoylphorbol Acetate	139-142	insulin	Homo sapiens	88-95
3450542-15	1987	TPA, an activator of protein kinase C, modulated both receptors in the same manner as CCK or carbachol.	Tetradecanoylphorbol Acetate	0-3	cholecystokinin	Homo sapiens	86-89
3124261-7	1988	The polyclonal and monoclonal anti-LFA-1 antibodies also inhibited phorbol ester (PMA)-dependent OKT3 activation of highly purified T cells.	Tetradecanoylphorbol Acetate	82-85	integrin beta 2	Mus musculus	35-40
3124262-6	1988	The deficient IFN-gamma production was compensated in RA by co-stimulation of PHA or OKT3 with phorbol myristic acetate (PMA).	Tetradecanoylphorbol Acetate	121-124	interferon gamma	Homo sapiens	14-23
3500949-9	1987	Phorbol 12-myristate 13-acetate attenuated the production of Ins(1,4,5)P3 generated by angiotensin II over the concentration range of 10(-10) to 10(-8) M; however, the Ca2+ signal was only inhibited at the 10(-10) M dose of angiotensin II.	Tetradecanoylphorbol Acetate	0-31	angiotensinogen	Rattus norvegicus	87-101
3500949-9	1987	Phorbol 12-myristate 13-acetate attenuated the production of Ins(1,4,5)P3 generated by angiotensin II over the concentration range of 10(-10) to 10(-8) M; however, the Ca2+ signal was only inhibited at the 10(-10) M dose of angiotensin II.	Tetradecanoylphorbol Acetate	0-31	angiotensinogen	Rattus norvegicus	224-238
2827655-3	1987	Phorbol 12-myristate 13-acetate (PMA) increased the cellular and medium ACE activity, accompanied by a marked morphological change in EC.	Tetradecanoylphorbol Acetate	0-31	angiotensin I converting enzyme	Homo sapiens	72-75
2827655-3	1987	Phorbol 12-myristate 13-acetate (PMA) increased the cellular and medium ACE activity, accompanied by a marked morphological change in EC.	Tetradecanoylphorbol Acetate	33-36	angiotensin I converting enzyme	Homo sapiens	72-75
2961801-5	1987	Furthermore, phorbol myristate acetate treatment or activation via the CD2 pathway induced phosphorylation of the CD4 and CD8 molecules of thymocytes, suggesting that these molecules may be functional in thymus.	Tetradecanoylphorbol Acetate	13-38	T-cell surface antigen CD2	Ovis aries	71-74
2826340-0	1987	TPA induction of Epstein-Barr virus early antigens in Raji cells is blocked by selective protein kinase-C inhibitors.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	89-105
3435475-5	1987	Catalase (CAT) and superoxide dismutase (SOD), both free-radical scavengers, and H7, a protein kinase C inhibitor, reversed to various extents the inhibitory effect of TPA on PS synthesis.	Tetradecanoylphorbol Acetate	168-171	catalase	Homo sapiens	0-8
3435475-5	1987	Catalase (CAT) and superoxide dismutase (SOD), both free-radical scavengers, and H7, a protein kinase C inhibitor, reversed to various extents the inhibitory effect of TPA on PS synthesis.	Tetradecanoylphorbol Acetate	168-171	catalase	Homo sapiens	10-13
3435475-5	1987	Catalase (CAT) and superoxide dismutase (SOD), both free-radical scavengers, and H7, a protein kinase C inhibitor, reversed to various extents the inhibitory effect of TPA on PS synthesis.	Tetradecanoylphorbol Acetate	168-171	superoxide dismutase 1	Homo sapiens	41-44
3435475-10	1987	Chlorobenzoic acid selectively stimulated the phosphorylation of protein lb, whereas CAT and SOD specifically attenuated the TPA-stimulated phosphorylation of this protein.	Tetradecanoylphorbol Acetate	125-128	catalase	Homo sapiens	85-88
3435475-10	1987	Chlorobenzoic acid selectively stimulated the phosphorylation of protein lb, whereas CAT and SOD specifically attenuated the TPA-stimulated phosphorylation of this protein.	Tetradecanoylphorbol Acetate	125-128	superoxide dismutase 1	Homo sapiens	93-96
2824494-2	1987	Preexposure of several different types of cells with only biologically active tumor promoter, i.e. 4 beta-phorbol 12-myristate 13-acetate (PMA), inhibited the specific binding of rTNF-alpha to its receptor.	Tetradecanoylphorbol Acetate	101-137	tumor necrosis factor	Rattus norvegicus	179-189
3121729-15	1987	mRNA analysis of adult L3T4-/Lyt-2- thymocytes stimulated with A23187 and phorbol myristate acetate confirms that mRNA for both IL-4 and IFN-gamma is induced in adult L3T4-/Lyt-2- thymocytes.	Tetradecanoylphorbol Acetate	74-99	interferon gamma	Mus musculus	137-146
2824494-2	1987	Preexposure of several different types of cells with only biologically active tumor promoter, i.e. 4 beta-phorbol 12-myristate 13-acetate (PMA), inhibited the specific binding of rTNF-alpha to its receptor.	Tetradecanoylphorbol Acetate	139-142	tumor necrosis factor	Rattus norvegicus	179-189
2824494-11	1987	Approximately 70% of TNF-alpha cell surface receptors could be regenerated within 16 h after PMA removal.	Tetradecanoylphorbol Acetate	93-96	tumor necrosis factor	Homo sapiens	21-30
3689124-2	1987	Protein kinase C has been implicated in tumor promotion because it is the receptor for the tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate (TPA) and mediates the action of this compound as well as that of other tumor promoters and growth factors.	Tetradecanoylphorbol Acetate	145-148	proline rich transmembrane protein 2	Homo sapiens	0-16
2451743-6	1987	The addition of thrombin after ionomycin accelerated the decline in [Ca2+]i back towards basal levels, an action mimicked by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	125-150	coagulation factor II, thrombin	Homo sapiens	16-24
3479244-1	1987	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced decreases in the catalytic activity and immunoreactivity of protein kinase C (PK-C) in the soluble fraction, accompanied by increases in their activities in the particulate fraction, of a human myeloid leukemia cell line KG-1.	Tetradecanoylphorbol Acetate	38-41	proline rich transmembrane protein 2	Homo sapiens	129-133
3479244-2	1987	TPA also caused a similar down-regulation and translocation of PK-C in KG-1a, a cloned subline shown to be resistant to the differentiating effect of TPA.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	63-67
3479244-4	1987	Immunocytochemical studies showed that, when KG-1 cells were treated with 10 nM TPA for 30 min, PK-C was translocated to the plasma membrane in the adherent subpopulation of cells, whereas the enzyme remained largely in the cytoplasm and perinuclear area of the nonadherent cells.	Tetradecanoylphorbol Acetate	80-83	proline rich transmembrane protein 2	Homo sapiens	96-100
3479244-5	1987	TPA, in contrast, caused a PK-C translocation primarily to the perinuclear region in KG-1a cells.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	27-31
3479244-7	1987	The present findings showed existence of certain differential effects of TPA on the PK-C system in the two leukemia cell lines, suggesting a molecular basis for the selective resistance of KG-1a cells to the differentiating action of TPA.	Tetradecanoylphorbol Acetate	73-76	proline rich transmembrane protein 2	Homo sapiens	84-88
3479244-7	1987	The present findings showed existence of certain differential effects of TPA on the PK-C system in the two leukemia cell lines, suggesting a molecular basis for the selective resistance of KG-1a cells to the differentiating action of TPA.	Tetradecanoylphorbol Acetate	234-237	proline rich transmembrane protein 2	Homo sapiens	84-88
3316463-5	1987	However, culture with TNF activated MP for increased hydrogen peroxide production in response to phorbol myristate acetate (PMA) and antagonized the IFN-induced decrease in the proportion of the MP bearing receptors for the Fc region of IgG2b.	Tetradecanoylphorbol Acetate	97-122	tumor necrosis factor	Mus musculus	22-25
3316463-5	1987	However, culture with TNF activated MP for increased hydrogen peroxide production in response to phorbol myristate acetate (PMA) and antagonized the IFN-induced decrease in the proportion of the MP bearing receptors for the Fc region of IgG2b.	Tetradecanoylphorbol Acetate	124-127	tumor necrosis factor	Mus musculus	22-25
3479244-1	1987	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced decreases in the catalytic activity and immunoreactivity of protein kinase C (PK-C) in the soluble fraction, accompanied by increases in their activities in the particulate fraction, of a human myeloid leukemia cell line KG-1.	Tetradecanoylphorbol Acetate	0-36	proline rich transmembrane protein 2	Homo sapiens	111-127
3479244-1	1987	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced decreases in the catalytic activity and immunoreactivity of protein kinase C (PK-C) in the soluble fraction, accompanied by increases in their activities in the particulate fraction, of a human myeloid leukemia cell line KG-1.	Tetradecanoylphorbol Acetate	0-36	proline rich transmembrane protein 2	Homo sapiens	129-133
3479244-1	1987	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced decreases in the catalytic activity and immunoreactivity of protein kinase C (PK-C) in the soluble fraction, accompanied by increases in their activities in the particulate fraction, of a human myeloid leukemia cell line KG-1.	Tetradecanoylphorbol Acetate	38-41	proline rich transmembrane protein 2	Homo sapiens	111-127
2826490-0	1987	Monoclonal antibody to the thrombin receptor stimulates DNA synthesis in combination with gamma-thrombin or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	108-133	coagulation factor II, thrombin	Homo sapiens	27-35
2824615-5	1987	Although exposure of neutrophils to TNF alone caused no superoxide anion production, it enhanced the O2- production in response to the chemotactic peptide, f-methionyl-leucyl-phenylalanine (FMLP) or the tumor promotor, phorbol myristate acetate, by as much as 278%.	Tetradecanoylphorbol Acetate	219-244	tumor necrosis factor	Homo sapiens	36-39
2824656-2	1987	Phorbol myristate acetate (PMA) and oleyl acetyl glycerol (OAG) both are able to rapidly downregulate TNF-binding capacity of normal and malignant cells derived from various tissues.	Tetradecanoylphorbol Acetate	0-25	tumor necrosis factor	Homo sapiens	102-105
2824656-2	1987	Phorbol myristate acetate (PMA) and oleyl acetyl glycerol (OAG) both are able to rapidly downregulate TNF-binding capacity of normal and malignant cells derived from various tissues.	Tetradecanoylphorbol Acetate	27-30	tumor necrosis factor	Homo sapiens	102-105
2826275-1	1987	Phorbol myristate acetate (PMA) stimulates pituitary hormone release by activating protein kinase C (PKC).	Tetradecanoylphorbol Acetate	0-25	proline rich transmembrane protein 2	Homo sapiens	83-99
2826275-1	1987	Phorbol myristate acetate (PMA) stimulates pituitary hormone release by activating protein kinase C (PKC).	Tetradecanoylphorbol Acetate	0-25	proline rich transmembrane protein 2	Homo sapiens	101-104
2451743-6	1987	The addition of thrombin after ionomycin accelerated the decline in [Ca2+]i back towards basal levels, an action mimicked by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	152-155	coagulation factor II, thrombin	Homo sapiens	16-24
2826275-1	1987	Phorbol myristate acetate (PMA) stimulates pituitary hormone release by activating protein kinase C (PKC).	Tetradecanoylphorbol Acetate	27-30	proline rich transmembrane protein 2	Homo sapiens	83-99
2826275-1	1987	Phorbol myristate acetate (PMA) stimulates pituitary hormone release by activating protein kinase C (PKC).	Tetradecanoylphorbol Acetate	27-30	proline rich transmembrane protein 2	Homo sapiens	101-104
2825698-1	1987	Pretreatment of rat prostatic epithelial cells with the tumor-promoting phorbol ester 4 beta-phorbol 12-myristate 13-acetate resulted in a decrease of both the potency of vasoactive intestinal peptide (VIP) upon the stimulation of cyclic AMP accumulation and the affinity of the receptors of this peptide.	Tetradecanoylphorbol Acetate	88-124	vasoactive intestinal peptide	Rattus norvegicus	202-205
3686356-4	1987	To determine whether this protein kinase regulates PTH release, we examined the effect of TPA on PTH release from human parathyroid tissue.	Tetradecanoylphorbol Acetate	90-93	parathyroid hormone	Homo sapiens	97-100
2824608-1	1987	A novel monocyte-derived neutrophil-activating peptide (MONAP) produced by lipopolysaccharide- and phorbol myristate acetate-stimulated human peripheral blood monocytes was purified by sequential ion exchange-high performance liquid chromatography (HPLC), size exclusion HPLC, and reversed phase HPLC.	Tetradecanoylphorbol Acetate	99-124	C-X-C motif chemokine ligand 8	Homo sapiens	8-54
3686356-7	1987	The effect on TPA on Ca++-regulated PTH release appeared biphasic.	Tetradecanoylphorbol Acetate	14-17	parathyroid hormone	Homo sapiens	36-39
3686356-8	1987	At low (0.25 mmol/L) Ca++ level, TPA suppressed PTH release to an average of 78% of maximal release without TPA (95% confidence interval, 67% to 88%) (p less than 0.01 compared to cells incubated without TPA).	Tetradecanoylphorbol Acetate	33-36	parathyroid hormone	Homo sapiens	48-51
3686356-9	1987	At high (2.25 mmol/L) Ca++ level, TPA augmented PTH release from an average of 39% of maximal release without TPA to 62% of maximal release without TPA (95% confidence level, 48% to 78%), an average augmentation of 22% (95% confidence level, 9% to 36%) (p less than 0.01 compared with cells incubated without TPA).	Tetradecanoylphorbol Acetate	34-37	parathyroid hormone	Homo sapiens	48-51
3686356-10	1987	TPA appeared to make PTH release independent of Ca++.	Tetradecanoylphorbol Acetate	0-3	parathyroid hormone	Homo sapiens	21-24
3686356-12	1987	Incubations with TPA demonstrated no toxicity as judged by trypan blue dye exclusion, linearity of PTH release, and cellular incorporation of tritiated leucine.	Tetradecanoylphorbol Acetate	17-20	parathyroid hormone	Homo sapiens	99-102
2829820-4	1987	Furthermore, activation of protein kinase C by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and by 1-oleoyl-2-acetylglycerol (OAG) abolishes angiotensin II-induced formation of inositol trisphosphate (IP3) in mesangial cells [Pfeilschifter (1986) FEBS Lett.	Tetradecanoylphorbol Acetate	65-101	angiotensinogen	Rattus norvegicus	157-171
2829820-4	1987	Furthermore, activation of protein kinase C by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and by 1-oleoyl-2-acetylglycerol (OAG) abolishes angiotensin II-induced formation of inositol trisphosphate (IP3) in mesangial cells [Pfeilschifter (1986) FEBS Lett.	Tetradecanoylphorbol Acetate	103-106	angiotensinogen	Rattus norvegicus	157-171
2829820-11	1987	Angiotensin II augments the increase in IP3 formation induced by GTP gamma S. However, when mesangial cells were pretreated with TPA there was a dose-dependent inhibition of the synergistic action of angiotensin II on GTP gamma S-induced IP3 production.	Tetradecanoylphorbol Acetate	129-132	angiotensinogen	Rattus norvegicus	0-14
2829820-11	1987	Angiotensin II augments the increase in IP3 formation induced by GTP gamma S. However, when mesangial cells were pretreated with TPA there was a dose-dependent inhibition of the synergistic action of angiotensin II on GTP gamma S-induced IP3 production.	Tetradecanoylphorbol Acetate	129-132	angiotensinogen	Rattus norvegicus	200-214
2824608-1	1987	A novel monocyte-derived neutrophil-activating peptide (MONAP) produced by lipopolysaccharide- and phorbol myristate acetate-stimulated human peripheral blood monocytes was purified by sequential ion exchange-high performance liquid chromatography (HPLC), size exclusion HPLC, and reversed phase HPLC.	Tetradecanoylphorbol Acetate	99-124	C-X-C motif chemokine ligand 8	Homo sapiens	56-61
2822168-7	1987	TPA induced the differentiation of the more mature pre-T-ALL cells of this case in vitro, and not only CD25 (Tac) antigen but also CD4 and CD8 antigens appeared on the cell surface.	Tetradecanoylphorbol Acetate	0-3	CD4 molecule	Homo sapiens	131-134
2444593-8	1987	Pretreatment of the cells with 1 nM TPA, 2 units/ml parathyroid hormone (PTH), or 15 microM forskolin blocked the effect of 2 microM TPA on [Ca2+]i.	Tetradecanoylphorbol Acetate	133-136	parathyroid hormone	Rattus norvegicus	52-71
2822168-8	1987	The low affinity binding of 125I-IL-2 to TPA-stimulated leukemia cells was observed in the three cases of pre-T-ALL tested, and the addition of recombinant IL-2 to TPA-stimulated cells showed no effect on cell proliferation.	Tetradecanoylphorbol Acetate	41-44	interleukin 2	Homo sapiens	33-37
3117136-6	1987	Enhanced phorbol myristate acetate-stimulated phosphorylation of a 48-kd substrate was observed in 32P-labeled intact cells treated with 1,25(OH)2D3 alone or in combination with IFN-gamma.	Tetradecanoylphorbol Acetate	9-34	interferon gamma	Homo sapiens	178-187
2822168-8	1987	The low affinity binding of 125I-IL-2 to TPA-stimulated leukemia cells was observed in the three cases of pre-T-ALL tested, and the addition of recombinant IL-2 to TPA-stimulated cells showed no effect on cell proliferation.	Tetradecanoylphorbol Acetate	164-167	interleukin 2	Homo sapiens	33-37
2822168-8	1987	The low affinity binding of 125I-IL-2 to TPA-stimulated leukemia cells was observed in the three cases of pre-T-ALL tested, and the addition of recombinant IL-2 to TPA-stimulated cells showed no effect on cell proliferation.	Tetradecanoylphorbol Acetate	164-167	interleukin 2	Homo sapiens	156-160
3311718-2	1987	Vanadate, concanavalin A (Con A), H2O2, and the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), seemingly unrelated compounds, have effects on cellular metabolism similar to those of insulin.	Tetradecanoylphorbol Acetate	63-100	insulin	Homo sapiens	195-202
3123107-3	1987	Using phorbol myristate acetate (PMA), which directly activates PKC, and Ca2+ ionophore A23187, which increases intracellular cytoplasmic free Ca2+ concentration, the induction of IL-2 secretion, IL-2R expression and cell proliferation were studied.	Tetradecanoylphorbol Acetate	6-31	interleukin 2	Homo sapiens	180-184
3123107-3	1987	Using phorbol myristate acetate (PMA), which directly activates PKC, and Ca2+ ionophore A23187, which increases intracellular cytoplasmic free Ca2+ concentration, the induction of IL-2 secretion, IL-2R expression and cell proliferation were studied.	Tetradecanoylphorbol Acetate	33-36	interleukin 2	Homo sapiens	180-184
3123107-4	1987	The results demonstrate that following stimulation with PMA and A23187, purified T cells from elderly subjects demonstrate low levels of IL-2 production, IL-2R expression and cell proliferation.	Tetradecanoylphorbol Acetate	56-59	interleukin 2	Homo sapiens	137-141
3322269-3	1987	Pretreating platelets with agents which activate protein kinase C [the phorbol ester phorbol myristate acetate (PMA) or the diacylglycerol 1-oleoyl-2-acetylglycerol (OAG)] inhibited increased intracellular calcium by PAF and thrombin in a dose-related manner.	Tetradecanoylphorbol Acetate	85-110	coagulation factor II, thrombin	Homo sapiens	225-233
3678377-0	1987	Inhibitory effects of tetradecanoylphorbol acetate and diacylglycerol on erythropoietin production in human renal carcinoma cell cultures.	Tetradecanoylphorbol Acetate	22-50	erythropoietin	Homo sapiens	73-87
3311718-2	1987	Vanadate, concanavalin A (Con A), H2O2, and the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), seemingly unrelated compounds, have effects on cellular metabolism similar to those of insulin.	Tetradecanoylphorbol Acetate	102-105	insulin	Homo sapiens	195-202
3311718-6	1987	Vanadate, Con A, H2O2, and TPA stimulate D-glucose uptake in adipocytes approximately 3-, 3-, 2-, and 0.6-fold, respectively, compared to the 5- to 10-fold stimulation of D-glucose uptake obtained with insulin.	Tetradecanoylphorbol Acetate	27-30	insulin	Homo sapiens	202-209
2822801-3	1987	In contrast, activation of PMN with PMA resulted in a dose-dependent decrease in FL-C5a binding, and activation with concentrations above 5 ng/ml resulted in a complete loss of binding.	Tetradecanoylphorbol Acetate	36-39	complement C5a receptor 1	Homo sapiens	84-87
3670389-4	1987	Some growth factors have tyrosine kinase activity and function without activation of PLC or protein kinase C. In this report we show that alpha-thrombin retains its mitogenicity in vascular smooth muscle cells depleted of protein kinase C. Phorbol-12-myristate-13-acetate (PMA) is found to be a potent growth inhibitor when added to vascular smooth muscle cells with alpha-thrombin.	Tetradecanoylphorbol Acetate	240-271	coagulation factor II, thrombin	Homo sapiens	144-152
3499460-3	1987	We found triggering of the CTL lytic response occurred when both a PK-C activator, phorbol 12-myristate 13-acetate (PMA), and a calcium ionophore, ionomycin, were added to CTL.	Tetradecanoylphorbol Acetate	83-114	proline rich transmembrane protein 2	Homo sapiens	67-71
3499460-3	1987	We found triggering of the CTL lytic response occurred when both a PK-C activator, phorbol 12-myristate 13-acetate (PMA), and a calcium ionophore, ionomycin, were added to CTL.	Tetradecanoylphorbol Acetate	116-119	proline rich transmembrane protein 2	Homo sapiens	67-71
3500472-0	1987	Expression of the human B-cell surface protein CD20: alteration by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	67-98	keratin 20	Homo sapiens	47-51
3500472-4	1987	Because phorbol 12-myristate 13-acetate (PMA) supports the activation signal initiated by monoclonal antibody 1F5, we studied the effect of PMA on CD20 expression.	Tetradecanoylphorbol Acetate	140-143	keratin 20	Homo sapiens	147-151
3500472-7	1987	Furthermore, PMA not only induced phosphorylation of CD20 protein on Raji cells but also increased the internalization of CD20 molecules; both phosphorylation and internalization of CD20 molecules were decreased with the protein kinase C inhibitor palmitoyl carnitine.	Tetradecanoylphorbol Acetate	13-16	keratin 20	Homo sapiens	53-57
3500472-7	1987	Furthermore, PMA not only induced phosphorylation of CD20 protein on Raji cells but also increased the internalization of CD20 molecules; both phosphorylation and internalization of CD20 molecules were decreased with the protein kinase C inhibitor palmitoyl carnitine.	Tetradecanoylphorbol Acetate	13-16	keratin 20	Homo sapiens	122-126
3500472-7	1987	Furthermore, PMA not only induced phosphorylation of CD20 protein on Raji cells but also increased the internalization of CD20 molecules; both phosphorylation and internalization of CD20 molecules were decreased with the protein kinase C inhibitor palmitoyl carnitine.	Tetradecanoylphorbol Acetate	13-16	keratin 20	Homo sapiens	122-126
3116098-0	1987	Large scale production and purification of human IL-2 from buffy coat lymphocytes stimulated with 12-O-tetradecanoylphorbol 13-acetate and calcium ionophore A23187.	Tetradecanoylphorbol Acetate	98-134	interleukin 2	Homo sapiens	49-53
3670389-4	1987	Some growth factors have tyrosine kinase activity and function without activation of PLC or protein kinase C. In this report we show that alpha-thrombin retains its mitogenicity in vascular smooth muscle cells depleted of protein kinase C. Phorbol-12-myristate-13-acetate (PMA) is found to be a potent growth inhibitor when added to vascular smooth muscle cells with alpha-thrombin.	Tetradecanoylphorbol Acetate	240-271	coagulation factor II, thrombin	Homo sapiens	373-381
3116098-4	1987	This degree of lymphocyte purity was important since phagocytes were inhibitory to 12-O-tetradecanoylphorbol 13-acetate/calcium ionophore (TPA/A23187)-induced IL-2 production when their concentration exceeded 15% of the total cells.	Tetradecanoylphorbol Acetate	83-119	interleukin 2	Homo sapiens	159-163
3670389-4	1987	Some growth factors have tyrosine kinase activity and function without activation of PLC or protein kinase C. In this report we show that alpha-thrombin retains its mitogenicity in vascular smooth muscle cells depleted of protein kinase C. Phorbol-12-myristate-13-acetate (PMA) is found to be a potent growth inhibitor when added to vascular smooth muscle cells with alpha-thrombin.	Tetradecanoylphorbol Acetate	273-276	coagulation factor II, thrombin	Homo sapiens	144-152
3116098-4	1987	This degree of lymphocyte purity was important since phagocytes were inhibitory to 12-O-tetradecanoylphorbol 13-acetate/calcium ionophore (TPA/A23187)-induced IL-2 production when their concentration exceeded 15% of the total cells.	Tetradecanoylphorbol Acetate	139-142	interleukin 2	Homo sapiens	159-163
3116098-6	1987	Using TPA/A23187 induction, up to 500 micrograms of IL-2 per liter were produced.	Tetradecanoylphorbol Acetate	6-9	interleukin 2	Homo sapiens	52-56
2820806-1	1987	Treatment of intact human platelets with the tumour-promoting phorbol ester, phorbol 12-myristate 13-acetate (PMA), specifically inhibited PGD2-induced cyclic AMP formation without affecting the regulation of cyclic AMP metabolism by PGI2, PGE1, 6-keto-PGE1, adenosine or adrenaline.	Tetradecanoylphorbol Acetate	77-108	prostaglandin D2 synthase	Homo sapiens	139-143
2820995-4	1987	In protein kinase C down-regulated cells (exposed to phorbol 12-myristate 13-acetate for 24 or 72 h), the delta pHi induced by thrombin was only partially attenuated.	Tetradecanoylphorbol Acetate	53-84	coagulation factor II, thrombin	Homo sapiens	127-135
2444456-3	1987	12-O-tetradecanoyl-phorbol-13-acetate (TPA) 50 ng/ml and 5-azacytidine 4 x 10(-6) M increased the amount of CEA, 2- and 1.5-fold respectively.	Tetradecanoylphorbol Acetate	0-37	CEA cell adhesion molecule 3	Homo sapiens	108-111
2444456-3	1987	12-O-tetradecanoyl-phorbol-13-acetate (TPA) 50 ng/ml and 5-azacytidine 4 x 10(-6) M increased the amount of CEA, 2- and 1.5-fold respectively.	Tetradecanoylphorbol Acetate	39-42	CEA cell adhesion molecule 3	Homo sapiens	108-111
2820806-1	1987	Treatment of intact human platelets with the tumour-promoting phorbol ester, phorbol 12-myristate 13-acetate (PMA), specifically inhibited PGD2-induced cyclic AMP formation without affecting the regulation of cyclic AMP metabolism by PGI2, PGE1, 6-keto-PGE1, adenosine or adrenaline.	Tetradecanoylphorbol Acetate	110-113	prostaglandin D2 synthase	Homo sapiens	139-143
3477472-3	1987	In the present work the activity of the c-abl and c-src oncogene-encoded tyrosine kinase was investigated during phorbol diester (TPA) induced differentiation of the K562 CML cells.	Tetradecanoylphorbol Acetate	130-133	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	50-55
2820700-5	1987	In the presence of hPRL, the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA), known to activate the Na+/H+ antiporter as well as protein kinase C in other cell systems, enhanced the hPRL-stimulated Nb2 cell mitogenesis.	Tetradecanoylphorbol Acetate	44-81	prolactin	Homo sapiens	19-23
2820700-5	1987	In the presence of hPRL, the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA), known to activate the Na+/H+ antiporter as well as protein kinase C in other cell systems, enhanced the hPRL-stimulated Nb2 cell mitogenesis.	Tetradecanoylphorbol Acetate	44-81	prolactin	Homo sapiens	193-197
2820700-5	1987	In the presence of hPRL, the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA), known to activate the Na+/H+ antiporter as well as protein kinase C in other cell systems, enhanced the hPRL-stimulated Nb2 cell mitogenesis.	Tetradecanoylphorbol Acetate	44-81	contactin 5	Rattus norvegicus	209-212
2960536-10	1987	Phorbol myristate acetate but not mAb 72-5D3 induced proliferation of MHDC when recombinant interleukin 2 (rIL2) was added.	Tetradecanoylphorbol Acetate	0-25	interleukin 2	Homo sapiens	92-105
2820700-5	1987	In the presence of hPRL, the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA), known to activate the Na+/H+ antiporter as well as protein kinase C in other cell systems, enhanced the hPRL-stimulated Nb2 cell mitogenesis.	Tetradecanoylphorbol Acetate	83-86	prolactin	Homo sapiens	19-23
2820700-5	1987	In the presence of hPRL, the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA), known to activate the Na+/H+ antiporter as well as protein kinase C in other cell systems, enhanced the hPRL-stimulated Nb2 cell mitogenesis.	Tetradecanoylphorbol Acetate	83-86	prolactin	Homo sapiens	193-197
2820700-5	1987	In the presence of hPRL, the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA), known to activate the Na+/H+ antiporter as well as protein kinase C in other cell systems, enhanced the hPRL-stimulated Nb2 cell mitogenesis.	Tetradecanoylphorbol Acetate	83-86	contactin 5	Rattus norvegicus	209-212
2820700-6	1987	TPA alone caused a dose- and time-dependent stimulation of H+ efflux in stationary cultures of Nb2 cells but had no effect on cell growth.	Tetradecanoylphorbol Acetate	0-3	contactin 5	Rattus norvegicus	95-98
3319626-5	1987	When the cells were plated in the presence of TPA on pFn or on pFn-fragments, containing the cell binding site, all the cells adhered rapidly, spread extensively, organized prominent F-actin stress fibers and typical ventral plaques of vinculin and alpha-actinin.	Tetradecanoylphorbol Acetate	46-49	actinin alpha 1	Homo sapiens	249-262
2820700-9	1987	TPA also increased the intracellular pH (pHi) of stationary cultures of Nb2 cells from 7.29 +/- 0.02 (n = 8) to a maximum of 7.45 +/- 0.03 (n = 10).	Tetradecanoylphorbol Acetate	0-3	contactin 5	Rattus norvegicus	72-75
2820700-15	1987	Although activation of the Na+/H+ exchange system is clearly an early consequence of the action of TPA on Nb2 cells, the failure of TPA to stimulate Nb2 cell proliferation suggests that stimulation of Na+/H+ exchange and protein kinase C activity are not sufficient to generate a mitogenic response in these cells.	Tetradecanoylphorbol Acetate	99-102	contactin 5	Rattus norvegicus	106-109
2449531-6	1987	Stimulation of C2 synthesis occurred when phospholipase C or phorbol myristate acetate (PMA) were added to the monocyte cultures, suggesting that PI cycle turnover and protein kinase-C (PK-C) activation are involved in the stimulation of C2 synthesis in monocytes.	Tetradecanoylphorbol Acetate	61-86	proline rich transmembrane protein 2	Homo sapiens	186-190
2821154-8	1987	Several other cell lines, the histiocytic line U937, the promyelocytic line HL60, the astrocytoma line U373 and the glioblastoma line SK-MG-4, in which BSF-2 was inducible with IL-1 or TPA, displayed BSF-2-R with Kd in the range of 1.3-6.4 X 10(-10) M, suggesting the autocrine mechanism in BSF-2 function.	Tetradecanoylphorbol Acetate	185-188	interleukin 6	Homo sapiens	152-157
2449531-7	1987	PMA, an activator of PK-C, stimulated the synthesis of C2, C3, B, P and C1-inhibitor approximately two-fold.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	21-25
2828616-1	1987	The antiinflammatory agent piroxicam caused dose dependent inhibition of N-formylmethionyl-leucyl-phenylalanine (FMLP) induced monocyte superoxide release in vitro, but had no effect on the response to serum treated zymosan, phorbol myristate acetate or the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	225-250	formyl peptide receptor 1	Homo sapiens	113-117
3498760-12	1987	The NK cells from the mice fed T4 synthesized lytic factors because nonspecific stimuli, such as 12-O-tetradecanoyl phorbol-13-acetate and the calcium ionophore A23187, induced release of lytic factors capable of lysing Yac-1 targets into the media.	Tetradecanoylphorbol Acetate	97-134	ADP-ribosyltransferase 1	Mus musculus	220-225
3653105-11	1987	Both Oco2Gro and PMA had dual effects on 5-hydroxytryptamine secretion induced by thrombin or collagen.	Tetradecanoylphorbol Acetate	17-20	coagulation factor II, thrombin	Homo sapiens	82-90
2957441-8	1987	LPS also inhibited Fc receptor expression on the human myelomonocytic cell line THP-1 after induction with IFN-gamma or phorbol myristate acetate alone or with both agents together.	Tetradecanoylphorbol Acetate	120-145	GLI family zinc finger 2	Homo sapiens	80-85
3477806-6	1987	We used RNA blot hybridization with both cDNA and synthetic oligonucleotide probes to prove our previous hypothesis that glycophorin B is encoded by a single 0.5- to 0.6-kb mRNA and to show that glycophorins A and B are negatively and coordinately regulated by a tumor-promoting phorbol ester, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	294-325	glycophorin B (MNS blood group)	Homo sapiens	121-134
3118114-6	1987	Cross-linking of 125I-labeled IL-2 to TPA activated B cell precursor ALL revealed the 55 kD Tac/CD25 protein and an additional protein of 75 kD.	Tetradecanoylphorbol Acetate	38-41	interleukin 2	Homo sapiens	30-34
2827680-4	1987	Arginine vasopressin desensitized testis was refractory to luteinizing hormone, follicle stimulating hormone, norepinephrine, dibutyryl cAMP, phorbol-myristate acetate and cholera toxin at 24 h. Arginine vasopressin desensitized testis showed recovery of response to norepinephrine at 48 h after the first injection.	Tetradecanoylphorbol Acetate	142-167	arginine vasopressin	Rattus norvegicus	9-20
2441853-6	1987	Concomitantly, TPA caused an increase in the synthesis of a basic keratin of Mr 60,000 and acidic keratins of Mr 52,000 and 49,000, markers for proliferating cells and primary epidermal cell cultures.	Tetradecanoylphorbol Acetate	15-18	lectin, mannose-binding, 1	Mus musculus	77-115
2820878-5	1987	The phorbol myristate acetate (PMA) or N-formylmethionylleucylphenylalanine (FMLP)-induced O2- release, corrected by surface area, was in the following order: neutrophils greater than cytoplasts greater than karyogranuloplasts.	Tetradecanoylphorbol Acetate	4-29	formyl peptide receptor 1	Homo sapiens	77-81
3040727-6	1987	Pretreatment with PMA consistently shortened the onset time of the neutrophil"s responses to agonists by about 1 s. When H2O2 production was initiated with PMA, a subsequent stimulation with the agonist fMLP elicited an immediate response (onset time less than 0.2 s) which preceded further changes in fura-2-detected [Ca2+]i.	Tetradecanoylphorbol Acetate	18-21	formyl peptide receptor 1	Homo sapiens	203-207
3040727-6	1987	Pretreatment with PMA consistently shortened the onset time of the neutrophil"s responses to agonists by about 1 s. When H2O2 production was initiated with PMA, a subsequent stimulation with the agonist fMLP elicited an immediate response (onset time less than 0.2 s) which preceded further changes in fura-2-detected [Ca2+]i.	Tetradecanoylphorbol Acetate	156-159	formyl peptide receptor 1	Homo sapiens	203-207
3113513-6	1987	Preincubation of B-PLL cells with IFN-gamma induces responsiveness to PMA, whereas IFN-gamma alone had no effect on these cells when pretreated with PMA.	Tetradecanoylphorbol Acetate	70-73	interferon gamma	Homo sapiens	34-43
3304983-1	1987	Insulin and 12-O-tetradecanoyl phorbol 13-acetate (TPA) each acutely stimulates hexose transport, amino acid uptake, and pyruvate dehydrogenase activity in the BC3H-1 myocyte in a nonadditive fashion, suggesting that the acute effects of insulin and TPA are mediated through a common mechanism of action.	Tetradecanoylphorbol Acetate	12-49	insulin	Homo sapiens	238-245
3304983-1	1987	Insulin and 12-O-tetradecanoyl phorbol 13-acetate (TPA) each acutely stimulates hexose transport, amino acid uptake, and pyruvate dehydrogenase activity in the BC3H-1 myocyte in a nonadditive fashion, suggesting that the acute effects of insulin and TPA are mediated through a common mechanism of action.	Tetradecanoylphorbol Acetate	51-54	insulin	Homo sapiens	238-245
3304983-1	1987	Insulin and 12-O-tetradecanoyl phorbol 13-acetate (TPA) each acutely stimulates hexose transport, amino acid uptake, and pyruvate dehydrogenase activity in the BC3H-1 myocyte in a nonadditive fashion, suggesting that the acute effects of insulin and TPA are mediated through a common mechanism of action.	Tetradecanoylphorbol Acetate	250-253	insulin	Homo sapiens	0-7
3304983-2	1987	Here we have demonstrated that while chronic incubation with insulin stimulated DNA synthesis by 3- to 6-fold, TPA, in contrast, did not stimulate DNA synthesis and, indeed, caused a 70% inhibition of insulin-stimulated DNA synthesis in a dose-dependent fashion.	Tetradecanoylphorbol Acetate	111-114	insulin	Homo sapiens	201-208
3304983-5	1987	Maximal TPA inhibition of insulin-stimulated DNA synthesis was observed at 100 nM with an ID50 of 30 nM TPA, values analogous to those required for TPA stimulation of hexose transport in the myocyte.	Tetradecanoylphorbol Acetate	8-11	insulin	Homo sapiens	26-33
3304983-5	1987	Maximal TPA inhibition of insulin-stimulated DNA synthesis was observed at 100 nM with an ID50 of 30 nM TPA, values analogous to those required for TPA stimulation of hexose transport in the myocyte.	Tetradecanoylphorbol Acetate	104-107	insulin	Homo sapiens	26-33
3304983-5	1987	Maximal TPA inhibition of insulin-stimulated DNA synthesis was observed at 100 nM with an ID50 of 30 nM TPA, values analogous to those required for TPA stimulation of hexose transport in the myocyte.	Tetradecanoylphorbol Acetate	104-107	insulin	Homo sapiens	26-33
3498728-3	1987	In contrast, tetrodotoxin, a blocker of voltage-sensitive Na+ channels, elevated the level of AChR alpha-subunit mRNA on top of the increase caused by either CGRP or CT. 12-O-Tetradecanoyl phorbol-13-acetate (TPA), an activator of protein kinase C, markedly decreased the cell surface and total content of [125I]alpha BGT-binding sites and reduced the rate of appearance of AChR at the surface of the myotubes without reducing the level of AChR alpha-subunit mRNA.	Tetradecanoylphorbol Acetate	170-207	cholinergic receptor nicotinic delta subunit	Gallus gallus	94-98
3498728-3	1987	In contrast, tetrodotoxin, a blocker of voltage-sensitive Na+ channels, elevated the level of AChR alpha-subunit mRNA on top of the increase caused by either CGRP or CT. 12-O-Tetradecanoyl phorbol-13-acetate (TPA), an activator of protein kinase C, markedly decreased the cell surface and total content of [125I]alpha BGT-binding sites and reduced the rate of appearance of AChR at the surface of the myotubes without reducing the level of AChR alpha-subunit mRNA.	Tetradecanoylphorbol Acetate	170-207	cholinergic receptor nicotinic delta subunit	Gallus gallus	374-378
3498728-3	1987	In contrast, tetrodotoxin, a blocker of voltage-sensitive Na+ channels, elevated the level of AChR alpha-subunit mRNA on top of the increase caused by either CGRP or CT. 12-O-Tetradecanoyl phorbol-13-acetate (TPA), an activator of protein kinase C, markedly decreased the cell surface and total content of [125I]alpha BGT-binding sites and reduced the rate of appearance of AChR at the surface of the myotubes without reducing the level of AChR alpha-subunit mRNA.	Tetradecanoylphorbol Acetate	170-207	cholinergic receptor nicotinic delta subunit	Gallus gallus	374-378
3498728-3	1987	In contrast, tetrodotoxin, a blocker of voltage-sensitive Na+ channels, elevated the level of AChR alpha-subunit mRNA on top of the increase caused by either CGRP or CT. 12-O-Tetradecanoyl phorbol-13-acetate (TPA), an activator of protein kinase C, markedly decreased the cell surface and total content of [125I]alpha BGT-binding sites and reduced the rate of appearance of AChR at the surface of the myotubes without reducing the level of AChR alpha-subunit mRNA.	Tetradecanoylphorbol Acetate	209-212	cholinergic receptor nicotinic delta subunit	Gallus gallus	94-98
3498728-4	1987	Moreover, TPA inhibited the increase of AChR alpha-subunit mRNA caused by tetrodotoxin without affecting that produced by CGRP or CT.	Tetradecanoylphorbol Acetate	10-13	cholinergic receptor nicotinic delta subunit	Gallus gallus	40-44
3114750-5	1987	The phorbol ester phorbol 12-tetradecanoate 13-acetate induces the same plasma cell surface antigens that are induced by interferon treatment, and this effect is also impaired by the ADPRT inhibitors.	Tetradecanoylphorbol Acetate	18-54	poly(ADP-ribose) polymerase 1	Homo sapiens	183-188
2888113-6	1987	Phorbol 12-myristate 13-acetate enhanced bradykinin-stimulated PGE2 synthesis but inhibited bradykinin-stimulated InsP formation.	Tetradecanoylphorbol Acetate	0-31	kininogen 1	Homo sapiens	41-51
2888113-6	1987	Phorbol 12-myristate 13-acetate enhanced bradykinin-stimulated PGE2 synthesis but inhibited bradykinin-stimulated InsP formation.	Tetradecanoylphorbol Acetate	0-31	kininogen 1	Homo sapiens	92-102
3496927-10	1987	B cells activated with either anti-Ig or TPA proliferated in the presence of IL-2, whereas B-CLL cells did not, although they all expressed the identical 60-kilodalton proteins by immunoprecipitation.	Tetradecanoylphorbol Acetate	41-44	interleukin 2	Homo sapiens	77-81
3038998-0	1987	Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	87-118	tumor necrosis factor	Homo sapiens	37-58
3038998-1	1987	Binding of radiolabeled tumor necrosis factor (TNF) to cell surface receptors was markedly reduced in human foreskin fibroblasts and cells from SV-80 and HeLa cell lines subsequent to treatment with interleukin 1 (IL-1) or 4 beta-phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	225-261	tumor necrosis factor	Homo sapiens	24-45
3038998-1	1987	Binding of radiolabeled tumor necrosis factor (TNF) to cell surface receptors was markedly reduced in human foreskin fibroblasts and cells from SV-80 and HeLa cell lines subsequent to treatment with interleukin 1 (IL-1) or 4 beta-phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	225-261	tumor necrosis factor	Homo sapiens	47-50
3038998-9	1987	A particularly notable dissimilarity was evident when comparing the rate of their reversal: the TNF receptor level was fully recovered within a few hours of removal of IL-1 or of the water-soluble analogue of PMA, 4 beta-phorbol-12,13-dibutyrate, from pretreated SV-80 cells; yet at that time resistance to the cytotoxicity of TNF was still prominent.	Tetradecanoylphorbol Acetate	209-212	tumor necrosis factor	Homo sapiens	96-99
3305494-3	1987	Fractionation of the cytosolic extracts from mitogen- or TPA-treated cells on Sephacryl S-300, TSK-400, and DEAE-Sephacel columns gave results suggesting that a single stimulated kinase accounted for the enhanced S6 and RRLSSLRA phosphorylating activities.	Tetradecanoylphorbol Acetate	57-60	IL2 inducible T cell kinase	Mus musculus	95-98
3624319-1	1987	We compared transferrin receptor (TfR) expression on human peripheral blood lymphocytes (PBL) activated by phorbol myristate acetate (PMA) or L-phytohemagglutinin (LPHA) using two techniques: (1) 125I-iron-saturated transferrin (FeTf) binding, (2) reactivity with monoclonal anti-TfR antibodies--OKT9 and B3/25.	Tetradecanoylphorbol Acetate	107-132	transferrin	Homo sapiens	12-23
3038302-5	1987	Mo exposed to CRP for 48 h also demonstrated elevated superoxide anion production when challenged with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	103-128	C-reactive protein	Homo sapiens	14-17
3115657-4	1987	At low concentrations (0.1 microM), A23187 synergized maximally with PMA to induce proliferation, to increase IL-2R mRNA levels and the expression of membrane IL-2R, and to produce a low but sufficient accumulation of IL-2 mRNA and IL-2 secretion.	Tetradecanoylphorbol Acetate	69-72	interleukin 2	Homo sapiens	110-114
3115657-4	1987	At low concentrations (0.1 microM), A23187 synergized maximally with PMA to induce proliferation, to increase IL-2R mRNA levels and the expression of membrane IL-2R, and to produce a low but sufficient accumulation of IL-2 mRNA and IL-2 secretion.	Tetradecanoylphorbol Acetate	69-72	interleukin 2	Homo sapiens	159-163
3624319-1	1987	We compared transferrin receptor (TfR) expression on human peripheral blood lymphocytes (PBL) activated by phorbol myristate acetate (PMA) or L-phytohemagglutinin (LPHA) using two techniques: (1) 125I-iron-saturated transferrin (FeTf) binding, (2) reactivity with monoclonal anti-TfR antibodies--OKT9 and B3/25.	Tetradecanoylphorbol Acetate	134-137	transferrin	Homo sapiens	12-23
2887717-6	1987	Although the cell preparations were relatively independent of exogenous IL-2 for the proliferative response to the combined stimulation of ionomycin and PMA at usual culture cell density, they needed exogenous IL-2 for sustained proliferation at lower culture cell density (5 X 10(3)/ml).	Tetradecanoylphorbol Acetate	153-156	interleukin 2	Homo sapiens	72-76
3110282-3	1987	CD3- Leu-11+ LGL require only a single signal for IFN-gamma production because phytohemagglutinin (PHA), phorbol myristate acetate (PMA), IL 2, or ionomycin can each independently induce IFN-gamma production.	Tetradecanoylphorbol Acetate	105-130	interferon gamma	Homo sapiens	50-59
3110282-3	1987	CD3- Leu-11+ LGL require only a single signal for IFN-gamma production because phytohemagglutinin (PHA), phorbol myristate acetate (PMA), IL 2, or ionomycin can each independently induce IFN-gamma production.	Tetradecanoylphorbol Acetate	105-130	interferon gamma	Homo sapiens	187-196
3110292-3	1987	However, treatment with 12-o-tetradecanoylphorbol-13-acetate, which promotes the loss of gap junctions, or culturing at low cell density to reduce intercellular contacts, significantly increased their sensitivity to LT/TNF.	Tetradecanoylphorbol Acetate	24-60	tumor necrosis factor	Mus musculus	219-222
2957786-4	1987	However, DNA synthesis was observed when recombinant interleukin 2 (IL-2) or other secondary signals, such as those provided by phorbol myristate acetate (PMA) or autologous accessory cells (AC), were also added.	Tetradecanoylphorbol Acetate	155-158	interleukin 2	Homo sapiens	53-66
2439242-6	1987	Pretreatment of monocytes with recombinant human interferon (IFN)-gamma or IFN-alpha for 18 hr resulted in enhanced release of labeled arachidonic acid and increased conversion to autocoids after TPA or ionophore stimulation.	Tetradecanoylphorbol Acetate	196-199	interferon gamma	Homo sapiens	49-71
3307015-6	1987	Immuno-fluorescence of PMA-treated cells suggested that vWFAg might be less granular than in control EC but the mean levels of vWF and vWFAg in the supernatant of cells incubated with PMA were not significantly different from control values.	Tetradecanoylphorbol Acetate	23-26	von Willebrand factor	Homo sapiens	56-59
2885371-3	1987	To further study the functional role of this molecule, Thy-1-negative variants were selected and analyzed for IL 2 production in response to phorbol-12-myristate-13-acetate (PMA) or to Con A.	Tetradecanoylphorbol Acetate	141-172	interleukin 2	Homo sapiens	110-114
2885371-3	1987	To further study the functional role of this molecule, Thy-1-negative variants were selected and analyzed for IL 2 production in response to phorbol-12-myristate-13-acetate (PMA) or to Con A.	Tetradecanoylphorbol Acetate	174-177	interleukin 2	Homo sapiens	110-114
2439242-6	1987	Pretreatment of monocytes with recombinant human interferon (IFN)-gamma or IFN-alpha for 18 hr resulted in enhanced release of labeled arachidonic acid and increased conversion to autocoids after TPA or ionophore stimulation.	Tetradecanoylphorbol Acetate	196-199	interferon alpha 1	Homo sapiens	75-84
3497814-2	1987	Somatomedin C, insulin, or transferrin had a weak effect in inducing DNA synthesis in G0-arrested cells when applied at 34 degrees C or with FBS at 39.5 degrees C. Fibroblast growth factor, platelet-derived growth factor, or 12-O-tetradecanoylphorbol 13-acetate had no such stimulatory effect at 39.5 degrees C. Binding of 125I-somatomedin C was not temperature-sensitive.	Tetradecanoylphorbol Acetate	225-261	transferrin	Rattus norvegicus	27-38
3114220-6	1987	The addition of catalase (n = 7) completely inhibited the effect of 250 micrograms PMA.	Tetradecanoylphorbol Acetate	83-86	catalase	Homo sapiens	16-24
3034432-3	1987	Footprinting analysis indicated that these TPA-responsive elements (TREs) are recognized by a common cellular protein: the previously described transcription factor AP-1.	Tetradecanoylphorbol Acetate	43-46	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	165-169
2441150-4	1987	In the presence of extracellular calcium, vasopressin stimulates the phosphorylation of a 45,000-dalton protein and to a lesser degree of a 20,000-dalton protein following a pattern observed with thrombin and 12-O-tetradecanoylphorbol-13-acetate, a phorbol ester.	Tetradecanoylphorbol Acetate	209-245	arginine vasopressin	Homo sapiens	42-53
3597547-0	1987	Parallel changes in amino acid transport and protein kinase C localization in LLC-PK1 cells treated with TPA or diradylglycerols.	Tetradecanoylphorbol Acetate	105-108	PKC	Sus scrofa	45-61
3597547-1	1987	Protein kinase C is considered to be a major target for tumor promoting phorbol esters such as 12-0-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	133-136	PKC	Sus scrofa	0-16
3597547-6	1987	TPA (0.01-1.0 microM) induces a shift of PKC activity from the cytosol back to the membrane-rich fraction in post-confluent cells with a concomitant 2-3 fold stimulation of MeAIB uptake.	Tetradecanoylphorbol Acetate	0-3	PKC	Sus scrofa	41-44
3153472-9	1987	Protein kinase C activators such as 12-O-tetradecanoyl-phorbol-13-acetate and dioctanoylglycerol were either near additive with CRF or also potentiated the action of CRF on ACTH secretion, respectively, even after DEX pretreatment.	Tetradecanoylphorbol Acetate	36-73	proopiomelanocortin	Homo sapiens	173-177
3607514-6	1987	Furthermore, TPA- and RA-treated cells showed a significant increase in acetylcholinesterase activity compared with non-treated cells.	Tetradecanoylphorbol Acetate	13-16	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-92
3128263-3	1987	The action of thrombin was mimicked by phorbol 12 myristate 13-acetate and 1,2-dioctanoylglycerol.	Tetradecanoylphorbol Acetate	39-70	coagulation factor II, thrombin	Homo sapiens	14-22
3607514-8	1987	These findings demonstrate that TPA and RA can regulate both the number of muscarinic receptors and the acetylcholinesterase activity in human SH-SY5Y neuroblastoma cells.	Tetradecanoylphorbol Acetate	32-35	acetylcholinesterase (Cartwright blood group)	Homo sapiens	104-124
3471761-3	1987	When the intact cells were pre-treated with 12-O-tetradecanoylphorbol-13-acetate, the fMLP- and GTP-induced formation of IP2 and IP3 was markedly reduced but the Ca2+-induced reactions were not reduced in the isolated membranes.	Tetradecanoylphorbol Acetate	44-80	formyl peptide receptor 1	Homo sapiens	86-90
3496852-5	1987	Phosphorylation of the c-erbB-2 protein was stimulated by TPA via protein kinase C in vivo.	Tetradecanoylphorbol Acetate	58-61	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-31
3294900-5	1987	Furthermore, rGM-CSF was observed to significantly enhance TNF secretion by monocytes stimulated with endotoxin and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	116-141	tumor necrosis factor	Homo sapiens	59-62
3294900-5	1987	Furthermore, rGM-CSF was observed to significantly enhance TNF secretion by monocytes stimulated with endotoxin and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	143-146	tumor necrosis factor	Homo sapiens	59-62
3572405-4	1987	The active phorbol ester phorbol-12-myristate-13-acetate (TPA) caused time- and concentration-dependent increases in the specific binding of [125I]Ang II to its receptors in neuronal cultures of normotensive and spontaneously hypertensive rat brains.	Tetradecanoylphorbol Acetate	25-56	angiotensinogen	Rattus norvegicus	147-153
3572405-4	1987	The active phorbol ester phorbol-12-myristate-13-acetate (TPA) caused time- and concentration-dependent increases in the specific binding of [125I]Ang II to its receptors in neuronal cultures of normotensive and spontaneously hypertensive rat brains.	Tetradecanoylphorbol Acetate	58-61	angiotensinogen	Rattus norvegicus	147-153
3572405-5	1987	The stimulatory effect of TPA on Ang II receptors was apparent within 15 min and reached a maximum between 1 and 2 h. Ang II specific binding had returned to control levels by 24 h. Various phorbol esters increased [125I]Ang II binding in accordance with their order of potency in stimulating protein kinase C activity.	Tetradecanoylphorbol Acetate	26-29	angiotensinogen	Rattus norvegicus	33-39
3572405-5	1987	The stimulatory effect of TPA on Ang II receptors was apparent within 15 min and reached a maximum between 1 and 2 h. Ang II specific binding had returned to control levels by 24 h. Various phorbol esters increased [125I]Ang II binding in accordance with their order of potency in stimulating protein kinase C activity.	Tetradecanoylphorbol Acetate	26-29	angiotensinogen	Rattus norvegicus	118-124
3572405-5	1987	The stimulatory effect of TPA on Ang II receptors was apparent within 15 min and reached a maximum between 1 and 2 h. Ang II specific binding had returned to control levels by 24 h. Various phorbol esters increased [125I]Ang II binding in accordance with their order of potency in stimulating protein kinase C activity.	Tetradecanoylphorbol Acetate	26-29	angiotensinogen	Rattus norvegicus	118-124
3033073-0	1987	Phorbol myristate acetate and the calcium ionophore A23187 synergistically induce release of LTB4 by human neutrophils: involvement of protein kinase C activation in regulation of the 5-lipoxygenase pathway.	Tetradecanoylphorbol Acetate	0-25	arachidonate 5-lipoxygenase	Homo sapiens	184-198
3033073-1	1987	Phorbol myristate acetate (PMA), a tumor-promoting phorbol ester, and the calcium ionophore A23187 synergistically induced the noncytotoxic release of leukotriene B4 (LTB4) and other 5-lipoxygenase products of arachidonic acid metabolism from human neutrophils.	Tetradecanoylphorbol Acetate	0-25	arachidonate 5-lipoxygenase	Homo sapiens	183-197
3033073-1	1987	Phorbol myristate acetate (PMA), a tumor-promoting phorbol ester, and the calcium ionophore A23187 synergistically induced the noncytotoxic release of leukotriene B4 (LTB4) and other 5-lipoxygenase products of arachidonic acid metabolism from human neutrophils.	Tetradecanoylphorbol Acetate	27-30	arachidonate 5-lipoxygenase	Homo sapiens	183-197
3033073-4	1987	PMA induced 5-lipoxygenase product release at a concentration causing a half-maximal effect of approximately 5 nM in the presence of A23187 (0.4 microM).	Tetradecanoylphorbol Acetate	0-3	arachidonate 5-lipoxygenase	Homo sapiens	12-26
3035015-3	1987	Exposure of these cells during 48 hr of culture to morphine and beta-END at pharmacologically (10(-8) M) and physiologically (10(-12) M) relevant concentrations, respectively, markedly suppressed peripheral blood mononuclear cell O-2 and H2O2 release in response to the respiratory burst stimuli opsonized zymosan and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	318-343	proopiomelanocortin	Homo sapiens	64-72
3106472-8	1987	We confirmed that a combination of TPA and lectins or TPA and anti-CD3 mAb is necessary to obtain full activation of Jurkat cells if this event is monitored by using measurement of IL 2 synthesis.	Tetradecanoylphorbol Acetate	35-38	interleukin 2	Homo sapiens	181-185
3106472-8	1987	We confirmed that a combination of TPA and lectins or TPA and anti-CD3 mAb is necessary to obtain full activation of Jurkat cells if this event is monitored by using measurement of IL 2 synthesis.	Tetradecanoylphorbol Acetate	54-57	interleukin 2	Homo sapiens	181-185
3106472-10	1987	Indeed, a combination of TPA and one of these two drugs induced maximal IL 2 synthesis.	Tetradecanoylphorbol Acetate	25-28	interleukin 2	Homo sapiens	72-76
3106473-4	1987	In T cells, the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) induced IL 2-R expression and proliferation associated with cytosol-to-membrane PKC translocation.	Tetradecanoylphorbol Acetate	30-67	proline rich transmembrane protein 2	Homo sapiens	154-157
3106473-4	1987	In T cells, the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) induced IL 2-R expression and proliferation associated with cytosol-to-membrane PKC translocation.	Tetradecanoylphorbol Acetate	69-72	proline rich transmembrane protein 2	Homo sapiens	154-157
3106473-5	1987	A dose of TPA (1 to 4 ng/ml) that induced about 50% of the maximal activation of PKC in the enzymatic assay also induced half-maximal effects on cell proliferation, IL 2-R expression, and PKC redistribution in intact T cells.	Tetradecanoylphorbol Acetate	10-13	proline rich transmembrane protein 2	Homo sapiens	81-84
3106473-5	1987	A dose of TPA (1 to 4 ng/ml) that induced about 50% of the maximal activation of PKC in the enzymatic assay also induced half-maximal effects on cell proliferation, IL 2-R expression, and PKC redistribution in intact T cells.	Tetradecanoylphorbol Acetate	10-13	proline rich transmembrane protein 2	Homo sapiens	188-191
3106473-7	1987	An inhibitor of PKC, chlorpromazine, was found to suppress TPA-mediated proliferation and IL 2-R expression, and inhibited T cell-derived PKC by competing with the phospholipid.	Tetradecanoylphorbol Acetate	59-62	proline rich transmembrane protein 2	Homo sapiens	16-19
3106473-8	1987	Ca2+ ionophore, which synergizes with TPA in induction of T cell proliferation, facilitated the TPA-induced PKC translocation to the membrane.	Tetradecanoylphorbol Acetate	38-41	proline rich transmembrane protein 2	Homo sapiens	108-111
3106473-8	1987	Ca2+ ionophore, which synergizes with TPA in induction of T cell proliferation, facilitated the TPA-induced PKC translocation to the membrane.	Tetradecanoylphorbol Acetate	96-99	proline rich transmembrane protein 2	Homo sapiens	108-111
2437919-4	1987	Both DiC8 and TPA induced histamine release were inhibited by H-7 (ID 50 = 37 mcM) and H-9 (IC 50 = 20 mcM).	Tetradecanoylphorbol Acetate	14-17	G protein-coupled receptor 50	Homo sapiens	87-106
3034291-4	1987	We confirm and extend the fact that these beta-adrenoceptors are of the beta 2-subtype, using selective ligands, photoaffinity labeling with [125I]CYP-diazirine identified two protein subunits: p59 and p72, the beta 2-adrenoceptor dependent adenylate cyclase desensitizes with half-life of 2.2 +/- 0.3 min whereas the loss of [125I]CYP binding from the cell surface requires longer exposure times to the agonist, phorbol-12-myristate-13-acetate (PMA) has no effect on the desensitization process nor does it have any effect on the modulation of beta-agonist affinity by guanyl nucleotides.	Tetradecanoylphorbol Acetate	413-444	DEAD-box helicase 17	Homo sapiens	202-205
3034291-4	1987	We confirm and extend the fact that these beta-adrenoceptors are of the beta 2-subtype, using selective ligands, photoaffinity labeling with [125I]CYP-diazirine identified two protein subunits: p59 and p72, the beta 2-adrenoceptor dependent adenylate cyclase desensitizes with half-life of 2.2 +/- 0.3 min whereas the loss of [125I]CYP binding from the cell surface requires longer exposure times to the agonist, phorbol-12-myristate-13-acetate (PMA) has no effect on the desensitization process nor does it have any effect on the modulation of beta-agonist affinity by guanyl nucleotides.	Tetradecanoylphorbol Acetate	446-449	DEAD-box helicase 17	Homo sapiens	202-205
3116404-3	1987	Lymphokine mRNA was induced by stimulating the cells with the phorbol diester PMA (TPA), with or without T-lymphocyte mitogens.	Tetradecanoylphorbol Acetate	83-86	interleukin 2	Homo sapiens	0-10
3495445-6	1987	Activation markers such as the transferrin and interleukin 2 (IL2) receptors were markedly increased after 24 h incubation with TPA and ionomycin.	Tetradecanoylphorbol Acetate	128-131	transferrin	Homo sapiens	31-42
3495445-6	1987	Activation markers such as the transferrin and interleukin 2 (IL2) receptors were markedly increased after 24 h incubation with TPA and ionomycin.	Tetradecanoylphorbol Acetate	128-131	interleukin 2	Homo sapiens	47-60
3495445-6	1987	Activation markers such as the transferrin and interleukin 2 (IL2) receptors were markedly increased after 24 h incubation with TPA and ionomycin.	Tetradecanoylphorbol Acetate	128-131	interleukin 2	Homo sapiens	62-65
2953337-1	1987	Treatment of mouse EL-4 cells with intracellular activators of protein kinase C, namely 4-phorbol 12-myristate 13-acetate (PMA) and diacylglycerol, resulted in 90% reduction in cell surface interferon-gamma (IFN-gamma) receptors as judged by iodinated-IFN-gamma binding.	Tetradecanoylphorbol Acetate	123-126	interferon gamma	Mus musculus	190-206
3031039-7	1987	Activation of the Na+/H+ antiport by subjecting VSMCs to phorbol 12-myristate 13-acetate (100 nM) prevented a subsequent effect of AII on the pHi profile.	Tetradecanoylphorbol Acetate	57-88	angiotensinogen	Rattus norvegicus	131-134
2953337-1	1987	Treatment of mouse EL-4 cells with intracellular activators of protein kinase C, namely 4-phorbol 12-myristate 13-acetate (PMA) and diacylglycerol, resulted in 90% reduction in cell surface interferon-gamma (IFN-gamma) receptors as judged by iodinated-IFN-gamma binding.	Tetradecanoylphorbol Acetate	123-126	interferon gamma	Mus musculus	208-217
2953337-1	1987	Treatment of mouse EL-4 cells with intracellular activators of protein kinase C, namely 4-phorbol 12-myristate 13-acetate (PMA) and diacylglycerol, resulted in 90% reduction in cell surface interferon-gamma (IFN-gamma) receptors as judged by iodinated-IFN-gamma binding.	Tetradecanoylphorbol Acetate	123-126	interferon gamma	Mus musculus	252-261
2953337-5	1987	Finally, specificity studies revealed that PMA is particularly effective in decreasing the binding of IFN-gamma to T-lymphocytes.	Tetradecanoylphorbol Acetate	43-46	interferon gamma	Mus musculus	102-111
3031037-10	1987	The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), stimulated Na+/H+ exchange in VSMC cultured for 24 h in serum-free medium, and the subsequent angiotensin II response was inhibited.	Tetradecanoylphorbol Acetate	19-55	angiotensinogen	Rattus norvegicus	157-171
3031037-10	1987	The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), stimulated Na+/H+ exchange in VSMC cultured for 24 h in serum-free medium, and the subsequent angiotensin II response was inhibited.	Tetradecanoylphorbol Acetate	57-60	angiotensinogen	Rattus norvegicus	157-171
3031037-12	1987	TPA caused no intracellular alkalinization of VSMC grown in serum, while the angiotensin II response was actually enhanced compared to VSMC deprived of serum for 24 h. We conclude that angiotensin II stimulates an amiloride-sensitive Na+/H+ exchange system in cultured VSMC which is mediated by protein kinase C-dependent and -independent mechanisms.	Tetradecanoylphorbol Acetate	0-3	angiotensinogen	Rattus norvegicus	185-199
3108589-2	1987	Using a cloned TNF-alpha specific cDNA probe, we show by Northern blot analysis that TNF-alpha mRNA rapidly accumulates in HL-60 cells following treatment with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	160-185	tumor necrosis factor	Homo sapiens	15-24
3104454-1	1987	Concanavalin A (Con A), which together with phorbol myristate acetate (PMA) can activate the human T cell line Jurkat to produce interleukin 2 (IL 2), is shown to depend on the expression of the T3/T cell antigen receptor heterodimer (T3/Ti) complex to induce activation.	Tetradecanoylphorbol Acetate	44-69	interleukin 2	Homo sapiens	129-142
3104454-1	1987	Concanavalin A (Con A), which together with phorbol myristate acetate (PMA) can activate the human T cell line Jurkat to produce interleukin 2 (IL 2), is shown to depend on the expression of the T3/T cell antigen receptor heterodimer (T3/Ti) complex to induce activation.	Tetradecanoylphorbol Acetate	44-69	interleukin 2	Homo sapiens	144-148
3104454-1	1987	Concanavalin A (Con A), which together with phorbol myristate acetate (PMA) can activate the human T cell line Jurkat to produce interleukin 2 (IL 2), is shown to depend on the expression of the T3/T cell antigen receptor heterodimer (T3/Ti) complex to induce activation.	Tetradecanoylphorbol Acetate	71-74	interleukin 2	Homo sapiens	129-142
3104454-1	1987	Concanavalin A (Con A), which together with phorbol myristate acetate (PMA) can activate the human T cell line Jurkat to produce interleukin 2 (IL 2), is shown to depend on the expression of the T3/T cell antigen receptor heterodimer (T3/Ti) complex to induce activation.	Tetradecanoylphorbol Acetate	71-74	interleukin 2	Homo sapiens	144-148
3548842-4	1987	HEL cells contained complexes of GpIIb and GpIIIa, and K562 cells expressed GpIIIa, but not GpIIb, when stimulated with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	120-151	integrin subunit beta 3	Homo sapiens	76-82
3478538-5	1987	TPA enhanced the adherent and phagocytic properties of HCL cells, producing a modest increase in the expression of membrane Ig, GP-70, and Leu-M5 markers, tartrate-resistant acid phosphatase, and Ig secretion.	Tetradecanoylphorbol Acetate	0-3	embigin	Homo sapiens	128-133
3496450-3	1987	Indomethacin, phorbol myristate acetate and irradiation of suppressor cells increased IL-2 values in rheumatoid SF and peripheral blood but did not restore normal IL-2 production.	Tetradecanoylphorbol Acetate	14-39	interleukin 2	Homo sapiens	86-90
3108589-2	1987	Using a cloned TNF-alpha specific cDNA probe, we show by Northern blot analysis that TNF-alpha mRNA rapidly accumulates in HL-60 cells following treatment with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	160-185	tumor necrosis factor	Homo sapiens	85-94
3108589-2	1987	Using a cloned TNF-alpha specific cDNA probe, we show by Northern blot analysis that TNF-alpha mRNA rapidly accumulates in HL-60 cells following treatment with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	187-190	tumor necrosis factor	Homo sapiens	15-24
3108589-2	1987	Using a cloned TNF-alpha specific cDNA probe, we show by Northern blot analysis that TNF-alpha mRNA rapidly accumulates in HL-60 cells following treatment with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	187-190	tumor necrosis factor	Homo sapiens	85-94
3101746-2	1987	We have previously demonstrated synergistic potentiation of secretion by phorbol 12-myristate 13-acetate (PMA) and platelet agonists such as thrombin and the thromboxane mimetic, U46619, with short (less than 2 min) pre-incubations of PMA, despite inhibition of agonist-induced [Ca2+]i mobilization and arachidonate/thromboxane release.	Tetradecanoylphorbol Acetate	235-238	coagulation factor II, thrombin	Homo sapiens	141-149
2953065-4	1987	The removal of PMA and subsequent addition of recombinant interleukin 2 (IL-2) or IL-2-containing supernatants effectively reversed the effect of PMA with recovery of antigen-specific lytic function of cells treated with 10(-8) M, while cells treated with 10(-5)M PMA only recovered lectin-dependent cytotoxic ability.	Tetradecanoylphorbol Acetate	146-149	interleukin 2	Homo sapiens	58-71
2953065-4	1987	The removal of PMA and subsequent addition of recombinant interleukin 2 (IL-2) or IL-2-containing supernatants effectively reversed the effect of PMA with recovery of antigen-specific lytic function of cells treated with 10(-8) M, while cells treated with 10(-5)M PMA only recovered lectin-dependent cytotoxic ability.	Tetradecanoylphorbol Acetate	146-149	interleukin 2	Homo sapiens	73-77
2953065-4	1987	The removal of PMA and subsequent addition of recombinant interleukin 2 (IL-2) or IL-2-containing supernatants effectively reversed the effect of PMA with recovery of antigen-specific lytic function of cells treated with 10(-8) M, while cells treated with 10(-5)M PMA only recovered lectin-dependent cytotoxic ability.	Tetradecanoylphorbol Acetate	146-149	interleukin 2	Homo sapiens	82-86
2953065-4	1987	The removal of PMA and subsequent addition of recombinant interleukin 2 (IL-2) or IL-2-containing supernatants effectively reversed the effect of PMA with recovery of antigen-specific lytic function of cells treated with 10(-8) M, while cells treated with 10(-5)M PMA only recovered lectin-dependent cytotoxic ability.	Tetradecanoylphorbol Acetate	146-149	interleukin 2	Homo sapiens	58-71
2953065-4	1987	The removal of PMA and subsequent addition of recombinant interleukin 2 (IL-2) or IL-2-containing supernatants effectively reversed the effect of PMA with recovery of antigen-specific lytic function of cells treated with 10(-8) M, while cells treated with 10(-5)M PMA only recovered lectin-dependent cytotoxic ability.	Tetradecanoylphorbol Acetate	146-149	interleukin 2	Homo sapiens	73-77
2953065-4	1987	The removal of PMA and subsequent addition of recombinant interleukin 2 (IL-2) or IL-2-containing supernatants effectively reversed the effect of PMA with recovery of antigen-specific lytic function of cells treated with 10(-8) M, while cells treated with 10(-5)M PMA only recovered lectin-dependent cytotoxic ability.	Tetradecanoylphorbol Acetate	146-149	interleukin 2	Homo sapiens	82-86
3102599-8	1987	Finally, in response to phorbol myristate acetate stimulation, both resident and peptone-induced MAC from MRL-lpr mice produced significantly more hydrogen peroxide than did those from control mice.	Tetradecanoylphorbol Acetate	24-49	Fas (TNF receptor superfamily member 6)	Mus musculus	110-113
3102604-1	1987	The phorbol myristate acetate (PMA) stimulation of the human neutrophil NADPH-oxidase has been demonstrated through the activation of protein kinase C (PK-C), using light membrane fractions from nitrogen-cavitated cells.	Tetradecanoylphorbol Acetate	4-29	proline rich transmembrane protein 2	Homo sapiens	134-150
3102604-1	1987	The phorbol myristate acetate (PMA) stimulation of the human neutrophil NADPH-oxidase has been demonstrated through the activation of protein kinase C (PK-C), using light membrane fractions from nitrogen-cavitated cells.	Tetradecanoylphorbol Acetate	4-29	proline rich transmembrane protein 2	Homo sapiens	152-156
3102604-1	1987	The phorbol myristate acetate (PMA) stimulation of the human neutrophil NADPH-oxidase has been demonstrated through the activation of protein kinase C (PK-C), using light membrane fractions from nitrogen-cavitated cells.	Tetradecanoylphorbol Acetate	31-34	proline rich transmembrane protein 2	Homo sapiens	134-150
3102604-1	1987	The phorbol myristate acetate (PMA) stimulation of the human neutrophil NADPH-oxidase has been demonstrated through the activation of protein kinase C (PK-C), using light membrane fractions from nitrogen-cavitated cells.	Tetradecanoylphorbol Acetate	31-34	proline rich transmembrane protein 2	Homo sapiens	152-156
3102607-3	1987	After stimulation with phorbol myristic acetate (PMA) and interleukin 2, essentially normal levels of surface antigen receptor were expressed by the lpr Lyt-2- L3T4- subpopulation but remained undetectable in the corresponding normal immature thymocyte population.	Tetradecanoylphorbol Acetate	49-52	Fas (TNF receptor superfamily member 6)	Mus musculus	149-152
2949779-4	1987	We conclude that TPA does not interfere with the fibronectin receptor on substrate-attached fibroblasts, but may influence intracellular fibronectin before it is bound to the extracellular matrix.	Tetradecanoylphorbol Acetate	17-20	fibronectin 1	Homo sapiens	137-148
3101746-5	1987	However, a longer pre-incubation with PMA (5 min) caused a significant reduction (20-50%) in the extent of collagen-induced 5-hydroxy[14C]tryptamine secretion and thromboxane B2 formation as seen earlier with thrombin, although collagen-induced [3]arachidonate release was still unaffected.	Tetradecanoylphorbol Acetate	38-41	coagulation factor II, thrombin	Homo sapiens	209-217
3101746-7	1987	Addition of PMA (400 nM) 10 s before these agonists in indomethacin-treated platelets resulted in synergistic interactions between agonist and PMA leading to enhanced 5-hydroxy[14C]tryptamine secretion, although this was notably less than the synergism observed previously between thrombin and PMA or U46619 and PMA.	Tetradecanoylphorbol Acetate	12-15	coagulation factor II, thrombin	Homo sapiens	281-289
3101746-7	1987	Addition of PMA (400 nM) 10 s before these agonists in indomethacin-treated platelets resulted in synergistic interactions between agonist and PMA leading to enhanced 5-hydroxy[14C]tryptamine secretion, although this was notably less than the synergism observed previously between thrombin and PMA or U46619 and PMA.	Tetradecanoylphorbol Acetate	143-146	coagulation factor II, thrombin	Homo sapiens	281-289
3101746-7	1987	Addition of PMA (400 nM) 10 s before these agonists in indomethacin-treated platelets resulted in synergistic interactions between agonist and PMA leading to enhanced 5-hydroxy[14C]tryptamine secretion, although this was notably less than the synergism observed previously between thrombin and PMA or U46619 and PMA.	Tetradecanoylphorbol Acetate	143-146	coagulation factor II, thrombin	Homo sapiens	281-289
3030588-6	1987	Superoxide dismutase, catalase, or 1 mM potassium cyanide inhibited 50% OPD oxidation obtained with PMA-stimulated normal PMNs.	Tetradecanoylphorbol Acetate	100-103	catalase	Homo sapiens	22-30
3545526-3	1987	With 0.5 microgram of TPA, the number of papillomas in the SSIN was 3-fold higher than in the SEN-CAR; the tumor incidence was 100 versus 60%, respectively.	Tetradecanoylphorbol Acetate	22-25	nuclear receptor subfamily 1, group I, member 3	Mus musculus	98-101
3494987-1	1987	Serosal preincubation of frog skin with tetradecanoyl phorbol acetate, TPA, an activator of protein kinase C, inhibits the hydrosmotic response elicited by vasopressin (AVP) but not that induced by 8br-cAMP.	Tetradecanoylphorbol Acetate	40-69	arginine vasopressin	Homo sapiens	156-167
2880863-5	1987	When adenoma cells were treated with 100 ng/mL IAP for 24 h, basal and TPA-induced GH secretion rates did not change.	Tetradecanoylphorbol Acetate	71-74	baculoviral IAP repeat-containing 7 (livin)	Mus musculus	44-50
3494671-1	1987	The effect of a B-cell differentiation factor (BCDF) found in the supernatant of the human bladder carcinoma cell line T-24 (T-24.BCDF) was assessed using the human lymphoblastoid line CESS (Muraguchi et al., 1981) and TPA-stimulated human B-CLL B cells.	Tetradecanoylphorbol Acetate	219-222	interleukin 6	Homo sapiens	16-45
3494671-1	1987	The effect of a B-cell differentiation factor (BCDF) found in the supernatant of the human bladder carcinoma cell line T-24 (T-24.BCDF) was assessed using the human lymphoblastoid line CESS (Muraguchi et al., 1981) and TPA-stimulated human B-CLL B cells.	Tetradecanoylphorbol Acetate	219-222	interleukin 6	Homo sapiens	47-51
3102504-7	1987	A 50-fold molar excess of PAI 2 over u-PA is found in both extracts and conditioned media of PMA-treated cells.	Tetradecanoylphorbol Acetate	93-96	plasminogen activator, urokinase	Homo sapiens	37-41
3039355-1	1987	Human monoblast-like histiocytic lymphoma cell line U937 was induced by a macrophage activating factor for O2- production (MAF-O) to produce O2- in response to phorbol myristate acetate stimulation.	Tetradecanoylphorbol Acetate	160-185	MAF bZIP transcription factor	Homo sapiens	123-126
2951735-9	1987	Analysis of the functional responsiveness of the three distinct groups of JA3 cell variants to different stimuli showed that all produced interleukin 2 in response to A23187 calcium ionophore plus phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	197-228	interleukin 2	Homo sapiens	138-151
3494987-1	1987	Serosal preincubation of frog skin with tetradecanoyl phorbol acetate, TPA, an activator of protein kinase C, inhibits the hydrosmotic response elicited by vasopressin (AVP) but not that induced by 8br-cAMP.	Tetradecanoylphorbol Acetate	71-74	arginine vasopressin	Homo sapiens	156-167
3593215-4	1987	The stimulatory effects of adrenaline on vasopressin-induced platelet activation were mimicked by the combination of the Ca2+ ionophore, ionomycin, and the protein kinase C activator, phorbol 12-myristate 13-acetate, but not by either of these agents alone.	Tetradecanoylphorbol Acetate	184-215	arginine vasopressin	Homo sapiens	41-52
3103464-3	1987	We have reported that high concentrations of TPA stimulate base-line short-circuit current (ISC) and inhibit the subsequent natriferic action of vasopressin.	Tetradecanoylphorbol Acetate	45-48	arginine vasopressin	Homo sapiens	145-156
3470005-2	1987	The protein, called Erythroid Differentiation Factor (EDF), was found in a 4 day culture of THP-1 cells performed in the presence of 4 beta-phorbol 12-myristate 13-acetate(PMA).	Tetradecanoylphorbol Acetate	133-171	inhibin subunit beta A	Homo sapiens	20-52
3470005-2	1987	The protein, called Erythroid Differentiation Factor (EDF), was found in a 4 day culture of THP-1 cells performed in the presence of 4 beta-phorbol 12-myristate 13-acetate(PMA).	Tetradecanoylphorbol Acetate	133-171	inhibin subunit beta A	Homo sapiens	54-57
3470005-2	1987	The protein, called Erythroid Differentiation Factor (EDF), was found in a 4 day culture of THP-1 cells performed in the presence of 4 beta-phorbol 12-myristate 13-acetate(PMA).	Tetradecanoylphorbol Acetate	133-171	GLI family zinc finger 2	Homo sapiens	92-97
3470005-2	1987	The protein, called Erythroid Differentiation Factor (EDF), was found in a 4 day culture of THP-1 cells performed in the presence of 4 beta-phorbol 12-myristate 13-acetate(PMA).	Tetradecanoylphorbol Acetate	172-175	inhibin subunit beta A	Homo sapiens	20-52
3470005-2	1987	The protein, called Erythroid Differentiation Factor (EDF), was found in a 4 day culture of THP-1 cells performed in the presence of 4 beta-phorbol 12-myristate 13-acetate(PMA).	Tetradecanoylphorbol Acetate	172-175	inhibin subunit beta A	Homo sapiens	54-57
3470005-2	1987	The protein, called Erythroid Differentiation Factor (EDF), was found in a 4 day culture of THP-1 cells performed in the presence of 4 beta-phorbol 12-myristate 13-acetate(PMA).	Tetradecanoylphorbol Acetate	172-175	GLI family zinc finger 2	Homo sapiens	92-97
3032719-1	1987	The effect of the catecholamine isoprenaline (10(-5) mol/l) and of the tumour promoting phorbolester tetradecanoyl-beta-phorbol acetate (10(-9) mol/l) on insulin stimulated 3-O-methyl-glucose transport was studied in freshly isolated human adipocytes.	Tetradecanoylphorbol Acetate	101-135	insulin	Homo sapiens	154-161
3102668-10	1987	In contrast, calcium ionophore plus PMA did induce the expression of a linked gene through the IL-2 5" flanking region in the mutant Jurkat cell line.	Tetradecanoylphorbol Acetate	36-39	interleukin 2	Homo sapiens	95-99
3492530-3	1987	Both anti-Ig- and anti-Bp35-dependent proliferation were augmented by the same co-stimulants, including a partially purified BCGF, recombinant IL 1, TPA, or each other.	Tetradecanoylphorbol Acetate	149-152	BP35	Homo sapiens	23-27
3585077-7	1987	Therefore, enhanced CL reactivity to PMA or Zymosan observed in the whole blood of the patients" population appears to be due to the presence of interferon in serum blood components as a consequence of IFN-infusion rather than to other symptoms or treatments of the neoplastic diseases, since the relative CL enhancement in patients is abrogated when isolated blood leukocytes are used for CL assay.	Tetradecanoylphorbol Acetate	37-40	interferon alpha 1	Homo sapiens	202-205
3819640-2	1987	The phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), which directly activates protein kinase C, was able to potentiate the melanophore response to alpha-MSH in a dose-dependent manner.	Tetradecanoylphorbol Acetate	18-55	alpha-msh	Anolis carolinensis	157-166
3819640-2	1987	The phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), which directly activates protein kinase C, was able to potentiate the melanophore response to alpha-MSH in a dose-dependent manner.	Tetradecanoylphorbol Acetate	57-60	alpha-msh	Anolis carolinensis	157-166
3819640-5	1987	We thus propose that the potentiation of alpha-MSH potency by TPA is through an interaction of protein kinase C with adenylate cyclase and, more specifically, that this interaction may be at the level of the linkage of the nucleotide regulatory subunit Ns with the catalytic moiety C of adenylate cyclase.	Tetradecanoylphorbol Acetate	62-65	alpha-msh	Anolis carolinensis	41-50
2433273-0	1987	Phorbol 12-myristate 13-acetate and vasopressin potentiate the effect of corticotropin-releasing factor on cyclic AMP production in rat anterior pituitary cells.	Tetradecanoylphorbol Acetate	0-31	corticotropin releasing hormone	Rattus norvegicus	73-103
2437015-4	1987	Treatment of T cells with TPA appears to bypass the requirement for an increase in [Ca2+]i for IL2 secretion and cell proliferation, indicating that various mitogens can trigger T cells through both [Ca2+]i-dependent and [Ca2+]i-independent pathways.	Tetradecanoylphorbol Acetate	26-29	interleukin 2	Homo sapiens	95-98
3102354-3	1987	When phorbol myristate acetate (PMA) and concanavalin A (Con A) or PMA alone were used to induce AC5-8 cells to secrete a cytotoxin, we found that the cytotoxin secreted was antigenically indistinguishable from LT. On the other hand, when AC5-8 cells were activated by PMA and A23187, they secreted another cytotoxin which was antigenically indistinguishable from TNF, in addition to LT.	Tetradecanoylphorbol Acetate	5-30	adenylate cyclase 5	Homo sapiens	97-102
3102354-3	1987	When phorbol myristate acetate (PMA) and concanavalin A (Con A) or PMA alone were used to induce AC5-8 cells to secrete a cytotoxin, we found that the cytotoxin secreted was antigenically indistinguishable from LT. On the other hand, when AC5-8 cells were activated by PMA and A23187, they secreted another cytotoxin which was antigenically indistinguishable from TNF, in addition to LT.	Tetradecanoylphorbol Acetate	32-35	adenylate cyclase 5	Homo sapiens	97-102
3102354-3	1987	When phorbol myristate acetate (PMA) and concanavalin A (Con A) or PMA alone were used to induce AC5-8 cells to secrete a cytotoxin, we found that the cytotoxin secreted was antigenically indistinguishable from LT. On the other hand, when AC5-8 cells were activated by PMA and A23187, they secreted another cytotoxin which was antigenically indistinguishable from TNF, in addition to LT.	Tetradecanoylphorbol Acetate	32-35	adenylate cyclase 5	Homo sapiens	239-244
3102354-3	1987	When phorbol myristate acetate (PMA) and concanavalin A (Con A) or PMA alone were used to induce AC5-8 cells to secrete a cytotoxin, we found that the cytotoxin secreted was antigenically indistinguishable from LT. On the other hand, when AC5-8 cells were activated by PMA and A23187, they secreted another cytotoxin which was antigenically indistinguishable from TNF, in addition to LT.	Tetradecanoylphorbol Acetate	32-35	tumor necrosis factor	Homo sapiens	364-367
3102354-3	1987	When phorbol myristate acetate (PMA) and concanavalin A (Con A) or PMA alone were used to induce AC5-8 cells to secrete a cytotoxin, we found that the cytotoxin secreted was antigenically indistinguishable from LT. On the other hand, when AC5-8 cells were activated by PMA and A23187, they secreted another cytotoxin which was antigenically indistinguishable from TNF, in addition to LT.	Tetradecanoylphorbol Acetate	67-70	adenylate cyclase 5	Homo sapiens	97-102
3102354-3	1987	When phorbol myristate acetate (PMA) and concanavalin A (Con A) or PMA alone were used to induce AC5-8 cells to secrete a cytotoxin, we found that the cytotoxin secreted was antigenically indistinguishable from LT. On the other hand, when AC5-8 cells were activated by PMA and A23187, they secreted another cytotoxin which was antigenically indistinguishable from TNF, in addition to LT.	Tetradecanoylphorbol Acetate	67-70	adenylate cyclase 5	Homo sapiens	239-244
3102354-3	1987	When phorbol myristate acetate (PMA) and concanavalin A (Con A) or PMA alone were used to induce AC5-8 cells to secrete a cytotoxin, we found that the cytotoxin secreted was antigenically indistinguishable from LT. On the other hand, when AC5-8 cells were activated by PMA and A23187, they secreted another cytotoxin which was antigenically indistinguishable from TNF, in addition to LT.	Tetradecanoylphorbol Acetate	67-70	tumor necrosis factor	Homo sapiens	364-367
2433273-2	1987	The potentiation of corticotropin-releasing factor (CRF)-stimulated cAMP production by vasopressin (VP) in the pituitary cell was investigated by studies on the interaction of CRF, VP, and the protein kinase C activator, phorbol 12-myristate 13-acetate (PMA) on cAMP, adenylate cyclase and phosphodiesterase.	Tetradecanoylphorbol Acetate	221-252	corticotropin releasing hormone	Rattus norvegicus	20-50
2433273-2	1987	The potentiation of corticotropin-releasing factor (CRF)-stimulated cAMP production by vasopressin (VP) in the pituitary cell was investigated by studies on the interaction of CRF, VP, and the protein kinase C activator, phorbol 12-myristate 13-acetate (PMA) on cAMP, adenylate cyclase and phosphodiesterase.	Tetradecanoylphorbol Acetate	221-252	arginine vasopressin	Rattus norvegicus	87-98
2433273-2	1987	The potentiation of corticotropin-releasing factor (CRF)-stimulated cAMP production by vasopressin (VP) in the pituitary cell was investigated by studies on the interaction of CRF, VP, and the protein kinase C activator, phorbol 12-myristate 13-acetate (PMA) on cAMP, adenylate cyclase and phosphodiesterase.	Tetradecanoylphorbol Acetate	221-252	arginine vasopressin	Rattus norvegicus	100-102
3103876-2	1987	In patients under thrombolytic therapy, even with tpA (tissue type plasminogen activator) fibrinogen is degraded, and fragment D derived from fibrinogen degradation, is evidenced in the plasma of treated patients.	Tetradecanoylphorbol Acetate	50-53	plasminogen activator, tissue type	Homo sapiens	55-88
3792558-4	1987	Thrombin added shortly after ionomycin could accelerate the recovery of [Ca2+]i and restore resting levels within 5 min, an effect that was mimicked by phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	152-183	coagulation factor II, thrombin	Homo sapiens	0-8
3792558-4	1987	Thrombin added shortly after ionomycin could accelerate the recovery of [Ca2+]i and restore resting levels within 5 min, an effect that was mimicked by phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	185-188	coagulation factor II, thrombin	Homo sapiens	0-8
3476168-0	1987	Phenotypic modulation of chronic lymphocytic, prolymphocytic, and lymphoplasmacytic leukemia cells by TPA: induction of TRAP isoenzyme 5 and HD6 (CD22) antigen and enhancement of IgM messenger RNA.	Tetradecanoylphorbol Acetate	102-105	CD22 molecule	Homo sapiens	146-150
3108164-0	1987	Interleukin-2 responses of MRL/lpr mouse splenocytes and lymph node cells induced by TPA and A23187.	Tetradecanoylphorbol Acetate	85-88	Fas (TNF receptor superfamily member 6)	Mus musculus	31-34
2820596-6	1987	In contrast, the addition of 1-naphthol to PMA-stimulated neutrophils interfered with superoxide-dependent cytochrome c reduction as well as luminol-dependent chemiluminescence and also resulted in protein binding.	Tetradecanoylphorbol Acetate	43-46	cytochrome c, somatic	Homo sapiens	107-119
3311846-1	1987	Endothelial cell activation by endotoxin (LPS), tumor necrosis factor (TNF), Interleukin-1-alpha, beta (IL-1-alpha, beta) and phorbolesters (TPA) results in increased monocyte adhesion.	Tetradecanoylphorbol Acetate	141-144	tumor necrosis factor	Homo sapiens	48-69
3311846-4	1987	Decrease in antigen-positive cells is delayed in LPS/TNF versus IL-1-alpha, beta/TPA-induced antigen expression (LPS vs. IL-1-beta: 60% vs. 5% at 24 h).	Tetradecanoylphorbol Acetate	81-84	interleukin 1 beta	Homo sapiens	121-130
3108164-1	1987	Treatment of splenocytes and lymph node cells of 5 month-old MRL/lpr mice with TPA induced IL-2-dependent proliferation of the cells in the presence of CA++.	Tetradecanoylphorbol Acetate	79-82	Fas (TNF receptor superfamily member 6)	Mus musculus	65-68
3108164-3	1987	The combination of TPA and A23187 in the lpr cells induced both proliferation and production of IL-2 in a Ca++-dependent fashion.	Tetradecanoylphorbol Acetate	19-22	Fas (TNF receptor superfamily member 6)	Mus musculus	41-44
3097142-0	1987	Interleukin 2 responses of lpr and normal L3T4-/Lyt-2- T cells induced by TPA plus A23187.	Tetradecanoylphorbol Acetate	74-77	interleukin 2	Homo sapiens	0-13
3495499-3	1987	The high cytosolic free Ca2+ level induced by anti-T3 or PHA declined more rapidly after addition of phorbol ester, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	116-141	lamin B receptor	Homo sapiens	57-60
3495499-3	1987	The high cytosolic free Ca2+ level induced by anti-T3 or PHA declined more rapidly after addition of phorbol ester, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	143-146	lamin B receptor	Homo sapiens	57-60
3097147-3	1987	The phorbol ester TPA stimulated ODC activity and [3H]thymidine incorporation to 54% and 31% that of a near-optimal mitogenic concentration of PRL (10 ng/ml), suggesting that mitogenesis in these cells is coupled to some degree to the activation of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	18-21	prolactin	Rattus norvegicus	143-146
2435389-0	1986	Ca2+ channel ligand sensitive responses to the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in vascular smooth muscle.	Tetradecanoylphorbol Acetate	61-97	carbonic anhydrase 2	Rattus norvegicus	0-3
2432432-3	1987	One of the targets of the phosphoinositide signalling system is the enzyme protein kinase C (PKC), which can be activated experimentally by tumour promoting phorbol esters, including 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	183-219	proline rich transmembrane protein 2	Homo sapiens	75-91
2432432-3	1987	One of the targets of the phosphoinositide signalling system is the enzyme protein kinase C (PKC), which can be activated experimentally by tumour promoting phorbol esters, including 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	183-219	proline rich transmembrane protein 2	Homo sapiens	93-96
2432432-3	1987	One of the targets of the phosphoinositide signalling system is the enzyme protein kinase C (PKC), which can be activated experimentally by tumour promoting phorbol esters, including 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	221-224	proline rich transmembrane protein 2	Homo sapiens	75-91
2432432-3	1987	One of the targets of the phosphoinositide signalling system is the enzyme protein kinase C (PKC), which can be activated experimentally by tumour promoting phorbol esters, including 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	221-224	proline rich transmembrane protein 2	Homo sapiens	93-96
3498045-1	1987	The phorbol ester TPA (12-O-tetradecanoylphorbol-13-acetate) stimulates baseline Na+ transport across frog skin epithelium and partially inhibits the natriferic response to vasopressin.	Tetradecanoylphorbol Acetate	18-21	arginine vasopressin	Homo sapiens	173-184
3498045-1	1987	The phorbol ester TPA (12-O-tetradecanoylphorbol-13-acetate) stimulates baseline Na+ transport across frog skin epithelium and partially inhibits the natriferic response to vasopressin.	Tetradecanoylphorbol Acetate	23-59	arginine vasopressin	Homo sapiens	173-184
3790579-10	1986	200,000-220,000) have properties similar to fibronectin, while p 9 and 11 both found in the cellular preparations and in the medium (Mr 180,000 and 150,000) were collagenase sensitive and their synthesis was inhibited by 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	221-257	SUB1 homolog, transcriptional regulator	Mus musculus	63-73
2435389-9	1986	TPA similarly potentiated responses to Ca2+ in Ca2+-free solution.	Tetradecanoylphorbol Acetate	0-3	carbonic anhydrase 2	Rattus norvegicus	39-42
2435389-9	1986	TPA similarly potentiated responses to Ca2+ in Ca2+-free solution.	Tetradecanoylphorbol Acetate	0-3	carbonic anhydrase 2	Rattus norvegicus	47-50
3026658-2	1986	We used the cholera toxin (CT), a cAMP elevating agent, to study the influence of this nucleotide on the production of interleukin 2 (IL-2) by human peripheral blood mononuclear cells stimulated by phytohemagglutinin and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	221-246	interleukin 2	Homo sapiens	119-132
2946400-3	1986	The number of cells with the ability to reduce nitroblue tetrazolium increased in the TPA-treated cell lines HL-60, ML-3, THP-1, and U-937, whereas the cell lines KG-1 and KLM-2 remained nitroblue tetrazolium negative.	Tetradecanoylphorbol Acetate	86-89	GLI family zinc finger 2	Homo sapiens	122-127
3026658-2	1986	We used the cholera toxin (CT), a cAMP elevating agent, to study the influence of this nucleotide on the production of interleukin 2 (IL-2) by human peripheral blood mononuclear cells stimulated by phytohemagglutinin and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	221-246	interleukin 2	Homo sapiens	134-138
3102242-1	1986	Human peripheral blood monocytes purified by counterflow elutriation were activated in vitro by human natural or recombinant interferon-gamma (IFN-gamma) as shown by enhanced killing of Listeria monocytogenes and increased production of H2O2 in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	257-282	interferon gamma	Homo sapiens	125-141
3501185-4	1987	Dexamethasone and Cyclosporin A (CsA) which inhibit early events of T cell activation and the expression of the interleukin-2 (IL-2) and gamma-interferon (gamma-IFN) genes also markedly suppress the expression of c-myc mRNA in Con A, and Con A + TPA-activated thymocytes.	Tetradecanoylphorbol Acetate	246-249	interleukin 2	Homo sapiens	112-125
3501185-4	1987	Dexamethasone and Cyclosporin A (CsA) which inhibit early events of T cell activation and the expression of the interleukin-2 (IL-2) and gamma-interferon (gamma-IFN) genes also markedly suppress the expression of c-myc mRNA in Con A, and Con A + TPA-activated thymocytes.	Tetradecanoylphorbol Acetate	246-249	interleukin 2	Homo sapiens	127-131
3102242-1	1986	Human peripheral blood monocytes purified by counterflow elutriation were activated in vitro by human natural or recombinant interferon-gamma (IFN-gamma) as shown by enhanced killing of Listeria monocytogenes and increased production of H2O2 in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	257-282	interferon gamma	Homo sapiens	143-152
3490990-3	1986	Furthermore, TPA can act synergistically with PHA to induce a greater number of colonies than can either mitogen alone.	Tetradecanoylphorbol Acetate	13-16	lamin B receptor	Homo sapiens	46-49
3490990-8	1986	In cultures stimulated with either TPA or PHA, approximately equal numbers of colonies are generated in the presence of IL-2, suggesting that T4 and T8 cells have similar proliferative capabilities.	Tetradecanoylphorbol Acetate	35-38	interleukin 2	Homo sapiens	120-124
3537181-9	1986	Treatment of HL-60 cells with phorbol myristate acetate resulted in the appearance of Mac-1 and p150,95 on the cell surface.	Tetradecanoylphorbol Acetate	30-55	integrin subunit beta 2	Homo sapiens	86-91
3023484-1	1986	The tumor co-promotor TPA is believed to enhance a wide variety of cellular processes by interacting with protein kinase C. Interleukin (IL 1) is a family of highly active molecules which augments the host response to infection.	Tetradecanoylphorbol Acetate	22-25	interleukin 1 beta	Homo sapiens	137-141
3023484-4	1986	Superoxide anion production by eosinophils stimulated with standard doses of the stimulant phorbol myristic acetate (TPA) (1 microgram/ml) was augmented approximately 20% by preincubation with IL 1.	Tetradecanoylphorbol Acetate	117-120	interleukin 1 beta	Homo sapiens	193-197
3023484-6	1986	At suboptimal doses of TPA, there was a dose-dependent inhibition of superoxide anion production in the presence of IL 1.	Tetradecanoylphorbol Acetate	23-26	interleukin 1 beta	Homo sapiens	116-120
3023484-8	1986	When IL 1 was added to eosinophils stimulated by TPA in the presence of calcium ionophore, there was a dose-dependent increase in superoxide anion production.	Tetradecanoylphorbol Acetate	49-52	interleukin 1 beta	Homo sapiens	5-9
3023484-14	1986	IL 1 may also modify the response of eosinophils to other stimuli such as ionophore and TPA.	Tetradecanoylphorbol Acetate	88-91	interleukin 1 beta	Homo sapiens	0-4
3025094-10	1986	Increased spontaneous and PMA-stimulated release of myeloperoxidase (MPO) was also observed in normal PB-PMNs pretreated with synovial fluid.	Tetradecanoylphorbol Acetate	26-29	myeloperoxidase	Homo sapiens	52-67
3025094-10	1986	Increased spontaneous and PMA-stimulated release of myeloperoxidase (MPO) was also observed in normal PB-PMNs pretreated with synovial fluid.	Tetradecanoylphorbol Acetate	26-29	myeloperoxidase	Homo sapiens	69-72
2946790-6	1986	Although less than half of resting PMNL bound Agg-CRP, up to 93% of PMNL activated with 1.0 micrograms/ml of phorbol myristate acetate (PMA) expressed binding sites for Agg-CRP.	Tetradecanoylphorbol Acetate	109-134	C-reactive protein	Homo sapiens	173-176
2946790-6	1986	Although less than half of resting PMNL bound Agg-CRP, up to 93% of PMNL activated with 1.0 micrograms/ml of phorbol myristate acetate (PMA) expressed binding sites for Agg-CRP.	Tetradecanoylphorbol Acetate	136-139	C-reactive protein	Homo sapiens	50-53
2946790-6	1986	Although less than half of resting PMNL bound Agg-CRP, up to 93% of PMNL activated with 1.0 micrograms/ml of phorbol myristate acetate (PMA) expressed binding sites for Agg-CRP.	Tetradecanoylphorbol Acetate	136-139	C-reactive protein	Homo sapiens	173-176
3540941-2	1986	Phorbol 12-myristate 13-acetate pretreatment abolished the increase in c-fos mRNA due to additional phorbol 12-myristate 13-acetate treatment and decreased but did not eliminate the ability of platelet-derived growth factor, fibroblast growth factor, fetal calf serum, bombesin, and insulin to stimulate c-fos mRNA.	Tetradecanoylphorbol Acetate	0-31	insulin	Homo sapiens	283-290
3093070-5	1986	1,25-(OH)2D3 inhibited the expression of interleukin 2 and gamma-interferon messenger RNA in human lymphocytes activated by phytohemagglutinin and 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	147-183	interleukin 2	Homo sapiens	41-54
3094603-2	1986	The proliferative response was correlated with the inducibility of receptors for IL 2 on the surface membrane of T-ALL and T-NHL cells by incubation with TPA or PHA for 18 hours.	Tetradecanoylphorbol Acetate	154-157	interleukin 2	Homo sapiens	81-85
3094603-4	1986	Accordingly, receptors for IL 2, initially absent from the cell surface, were found on high proportions of the T-ALL and T-NHL cells after in vitro exposure to TPA.	Tetradecanoylphorbol Acetate	160-163	interleukin 2	Homo sapiens	27-31
3094603-10	1986	The results from this study indicate that the requirements of endogenous v exogenous IL 2 for cell proliferation in T-ALL and T-NHL and IL 2 receptor activation by PHA and TPA vary from patient to patient.	Tetradecanoylphorbol Acetate	172-175	interleukin 2	Homo sapiens	136-140
2430623-2	1986	Basal release and release in response to the beta-adrenergic agonist, terbutaline and 12-O-tetradecanoylphorbol 13-acetate (TPA) were significantly decreased in the presence of substance P.	Tetradecanoylphorbol Acetate	86-122	tachykinin precursor 1	Homo sapiens	177-188
2430623-2	1986	Basal release and release in response to the beta-adrenergic agonist, terbutaline and 12-O-tetradecanoylphorbol 13-acetate (TPA) were significantly decreased in the presence of substance P.	Tetradecanoylphorbol Acetate	124-127	tachykinin precursor 1	Homo sapiens	177-188
2430623-3	1986	Inhibitory effects of substance P were noted following a 1 h exposure of primary cultures of Type II cells in vitro and persisted up to 3 h in the presence of the secretagogues, TPA and terbutaline.	Tetradecanoylphorbol Acetate	178-181	tachykinin precursor 1	Homo sapiens	22-33
2430623-4	1986	The IC50 values for substance P inhibition of [3H]PC release were 10 microM for basal release, 40 microM for TPA-induced release and 50 microM for terbutaline-induced release.	Tetradecanoylphorbol Acetate	109-112	tachykinin precursor 1	Homo sapiens	20-31
3778497-1	1986	Enhancement of Ca2+-dependent high K+-evoked catecholamine secretion was observed after pretreatment of cultured bovine adrenal chromaffin cells with the phorbol ester 4B-phorbol 12-myristate 13-acetate (TPA) in the absence of added extracellular Ca2+.	Tetradecanoylphorbol Acetate	171-202	plasminogen activator, tissue type	Bos taurus	204-207
3490288-14	1986	IL-2 and TPA, however, had profound influence on the NK function of the cells with enhancement in the case of IL-2 and marked suppression when stimulated by TPA.	Tetradecanoylphorbol Acetate	9-12	interleukin 2	Homo sapiens	110-114
3490288-14	1986	IL-2 and TPA, however, had profound influence on the NK function of the cells with enhancement in the case of IL-2 and marked suppression when stimulated by TPA.	Tetradecanoylphorbol Acetate	157-160	interleukin 2	Homo sapiens	0-4
3102134-2	1986	The present study shows that relatively immature T6+ human thymocytes as well as the more mature T3+ thymocytes could be induced to express functional IL-2 receptors when activated with either Concanavalin A (Con A), Con A and 12-O-tetradecanoylphorbol 13-acetate (TPA) or IL-2 in combination with Con A or TPA.	Tetradecanoylphorbol Acetate	227-263	interleukin 2	Homo sapiens	151-155
2876983-3	1986	Activators of protein kinase C such as teleocidin and 4 beta-phorbol 12-myristate 13-acetate (PMA) double the cyclic AMP accumulation induced by GRF, with no apparent effect on GRF potency; an inactive 4-alpha-PMA has no such action in cultured anterior pituitary cells.	Tetradecanoylphorbol Acetate	54-92	growth hormone releasing hormone	Homo sapiens	145-148
3102134-2	1986	The present study shows that relatively immature T6+ human thymocytes as well as the more mature T3+ thymocytes could be induced to express functional IL-2 receptors when activated with either Concanavalin A (Con A), Con A and 12-O-tetradecanoylphorbol 13-acetate (TPA) or IL-2 in combination with Con A or TPA.	Tetradecanoylphorbol Acetate	265-268	interleukin 2	Homo sapiens	151-155
3102134-2	1986	The present study shows that relatively immature T6+ human thymocytes as well as the more mature T3+ thymocytes could be induced to express functional IL-2 receptors when activated with either Concanavalin A (Con A), Con A and 12-O-tetradecanoylphorbol 13-acetate (TPA) or IL-2 in combination with Con A or TPA.	Tetradecanoylphorbol Acetate	307-310	interleukin 2	Homo sapiens	151-155
3464595-9	1986	Upon TPA treatment, pre-existing p17 was rapidly phosphorylated to pp17.	Tetradecanoylphorbol Acetate	5-8	family with sequence similarity 72 member B	Homo sapiens	33-36
3464595-13	1986	Quantitatively, therefore, the phosphorylation of p17 to pp17 is one of the most prominent early biochemical responses to TPA treatment.	Tetradecanoylphorbol Acetate	122-125	family with sequence similarity 72 member B	Homo sapiens	50-53
3095338-9	1986	In summary, the ability to TPA and teleocidin to increase the rate of production of MRP and MEP correlated with the ability of these tumor promoters to stimulate DNA synthesis in quiescent 3T3 and TNR-9 cells.	Tetradecanoylphorbol Acetate	27-30	tenascin R	Mus musculus	197-200
2876983-3	1986	Activators of protein kinase C such as teleocidin and 4 beta-phorbol 12-myristate 13-acetate (PMA) double the cyclic AMP accumulation induced by GRF, with no apparent effect on GRF potency; an inactive 4-alpha-PMA has no such action in cultured anterior pituitary cells.	Tetradecanoylphorbol Acetate	94-97	growth hormone releasing hormone	Homo sapiens	145-148
2876983-5	1986	PMA, phorbol 12,13-dibutyrate, and teleocidin ED50 values for potentiating GRF activity are similar to those obtained for direct protein kinase C activation.	Tetradecanoylphorbol Acetate	0-3	growth hormone releasing hormone	Homo sapiens	75-78
3093578-4	1986	When stimulated in short-term culture with a combination of phorbol ester (PMA) and calcium ionophore, Lyt-2-/L3T4- thymocytes proliferated in a largely IL 2-dependent fashion.	Tetradecanoylphorbol Acetate	75-78	interleukin 2	Homo sapiens	153-157
3021152-3	1986	On the other hand, 12-O-tetradecanoyl phorbol acetate(TPA) mainly inhibited the conversion of phosphatidylinositol 4-phosphate(PIP) to PIP2 without a significant effect on the fMLP-induced breakdown of PIP2, though direct effect of TPA on PI and PIP kinases was not demonstrated in isolated plasma membranes.	Tetradecanoylphorbol Acetate	19-53	prolactin induced protein	Homo sapiens	127-130
3758353-2	1986	When phorbol 12-myristate 13-acetate (PMA) was added to washed platelet suspensions 10 s prior to either thrombin or ADP, it caused a dose-dependent inhibition of shape change correlated with decreased myosin association with the cytoskeleton and with inhibition of the calcium transient measured in fura-2-loaded platelets.	Tetradecanoylphorbol Acetate	5-36	coagulation factor II, thrombin	Homo sapiens	105-113
3758353-2	1986	When phorbol 12-myristate 13-acetate (PMA) was added to washed platelet suspensions 10 s prior to either thrombin or ADP, it caused a dose-dependent inhibition of shape change correlated with decreased myosin association with the cytoskeleton and with inhibition of the calcium transient measured in fura-2-loaded platelets.	Tetradecanoylphorbol Acetate	38-41	coagulation factor II, thrombin	Homo sapiens	105-113
3019453-7	1986	When compared with peripheral blood PMNs, these bone marrow neutrophils had a lower alkaline phosphatase activity, decreased ingestion of Oil Red O-coated particles, impaired superoxide release on stimulation with the chemotactic peptide Fmet-leu-phe (FMLP) or the tumor promotor phorbol myristate acetate (PMA), and less activity of the NADPH-dependent oxidase.	Tetradecanoylphorbol Acetate	280-305	formyl peptide receptor 1	Homo sapiens	238-250
3019453-7	1986	When compared with peripheral blood PMNs, these bone marrow neutrophils had a lower alkaline phosphatase activity, decreased ingestion of Oil Red O-coated particles, impaired superoxide release on stimulation with the chemotactic peptide Fmet-leu-phe (FMLP) or the tumor promotor phorbol myristate acetate (PMA), and less activity of the NADPH-dependent oxidase.	Tetradecanoylphorbol Acetate	307-310	formyl peptide receptor 1	Homo sapiens	238-250
3021152-3	1986	On the other hand, 12-O-tetradecanoyl phorbol acetate(TPA) mainly inhibited the conversion of phosphatidylinositol 4-phosphate(PIP) to PIP2 without a significant effect on the fMLP-induced breakdown of PIP2, though direct effect of TPA on PI and PIP kinases was not demonstrated in isolated plasma membranes.	Tetradecanoylphorbol Acetate	19-53	prolactin induced protein	Homo sapiens	135-138
3021152-3	1986	On the other hand, 12-O-tetradecanoyl phorbol acetate(TPA) mainly inhibited the conversion of phosphatidylinositol 4-phosphate(PIP) to PIP2 without a significant effect on the fMLP-induced breakdown of PIP2, though direct effect of TPA on PI and PIP kinases was not demonstrated in isolated plasma membranes.	Tetradecanoylphorbol Acetate	54-57	prolactin induced protein	Homo sapiens	127-130
3021152-3	1986	On the other hand, 12-O-tetradecanoyl phorbol acetate(TPA) mainly inhibited the conversion of phosphatidylinositol 4-phosphate(PIP) to PIP2 without a significant effect on the fMLP-induced breakdown of PIP2, though direct effect of TPA on PI and PIP kinases was not demonstrated in isolated plasma membranes.	Tetradecanoylphorbol Acetate	54-57	prolactin induced protein	Homo sapiens	135-138
3021152-3	1986	On the other hand, 12-O-tetradecanoyl phorbol acetate(TPA) mainly inhibited the conversion of phosphatidylinositol 4-phosphate(PIP) to PIP2 without a significant effect on the fMLP-induced breakdown of PIP2, though direct effect of TPA on PI and PIP kinases was not demonstrated in isolated plasma membranes.	Tetradecanoylphorbol Acetate	232-235	prolactin induced protein	Homo sapiens	127-130
3021152-4	1986	Concerning Ca2+ mobilization, both cAMP-increasing agents and TPA inhibited the fMLP-induced second phase of Ca2+ elevation, while they did not affect the first phase of Ca2+ rapid increase.	Tetradecanoylphorbol Acetate	62-65	formyl peptide receptor 1	Homo sapiens	80-84
3755722-9	1986	Furthermore, we show that the expression of the glycophorin A and B genes are coordinately regulated by tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	135-171	glycophorin A (MNS blood group)	Homo sapiens	48-67
3017754-5	1986	However, uPA synthesis in response to phorbol-12-myristate-13-acetate by all of the mutants was similar to parental, which indicates that enzyme induction mediated by phorbol esters does not involve cAMP or cAMP-PK.	Tetradecanoylphorbol Acetate	38-69	plasminogen activator, urokinase	Sus scrofa	9-12
3820841-0	1986	[Enhanced binding of 131I-labeled monoclonal anti-CEA antibody to a CEA producing lung carcinoma cell line (QG56) after phorbol ester (TPA) treatment].	Tetradecanoylphorbol Acetate	135-138	CEA cell adhesion molecule 3	Homo sapiens	50-53
3820841-0	1986	[Enhanced binding of 131I-labeled monoclonal anti-CEA antibody to a CEA producing lung carcinoma cell line (QG56) after phorbol ester (TPA) treatment].	Tetradecanoylphorbol Acetate	135-138	CEA cell adhesion molecule 3	Homo sapiens	68-71
3099777-6	1986	The combined addition of TPA and the Ca2+ ionophore, A23187, which, like angiotensin II, evokes a sustained increase in aldosterone production, reproduced the temporal patterns of protein phosphorylation seen after angiotensin II action.	Tetradecanoylphorbol Acetate	25-28	angiotensinogen	Homo sapiens	73-87
3099777-6	1986	The combined addition of TPA and the Ca2+ ionophore, A23187, which, like angiotensin II, evokes a sustained increase in aldosterone production, reproduced the temporal patterns of protein phosphorylation seen after angiotensin II action.	Tetradecanoylphorbol Acetate	25-28	angiotensinogen	Homo sapiens	215-229
2428622-1	1986	I. Pairs of anti-T11.1 and T11.2 (CD2 subgroups) are strongly mitogenic for T cells in presence of 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	99-135	T-cell surface antigen CD2	Ovis aries	34-37
2428622-4	1986	The combined data demonstrate that in the absence of TPA only few pairs of mAb directed at distinct epitopes of the CD2 molecule were mitogenic for T cells (in approximately 30% of the population tested), and in the presence of a submitogenic dose of TPA the majority of T11.1 anti-CD2-mAb (9 out of 11) were strongly mitogenic for T cells of all individuals tested when paired with T11.2 anti-CD2 mAb.	Tetradecanoylphorbol Acetate	251-254	T-cell surface antigen CD2	Ovis aries	116-119
3017998-5	1986	In contrast, activation of protein kinase C by phorbol myristate acetate markedly stimulated the internalization of both occupied and unoccupied transferrin receptors, even in cells with very low [Ca2+]i.	Tetradecanoylphorbol Acetate	47-72	transferrin	Homo sapiens	145-156
2948494-3	1986	With increasing times of incubation with PMA (10 s-5 min), the rise in [Ca2+]i induced by thrombin and the TxA2 mimetic, U46619, was increasingly inhibited (90-100% with 5 min incubation) and, correlating with this, thrombin-induced [3H]arachidonate, TxB2 and beta-thromboglobulin (beta TG) release were also inhibited.	Tetradecanoylphorbol Acetate	41-44	coagulation factor II, thrombin	Homo sapiens	90-98
2948494-3	1986	With increasing times of incubation with PMA (10 s-5 min), the rise in [Ca2+]i induced by thrombin and the TxA2 mimetic, U46619, was increasingly inhibited (90-100% with 5 min incubation) and, correlating with this, thrombin-induced [3H]arachidonate, TxB2 and beta-thromboglobulin (beta TG) release were also inhibited.	Tetradecanoylphorbol Acetate	41-44	coagulation factor II, thrombin	Homo sapiens	216-224
2878123-8	1986	The phorbol ester, phorbol 12-myristate 13-acetate (PMA) in combination with phytohemagglutinin or concanavalin A, were required for maximal release of LT and IL-2.	Tetradecanoylphorbol Acetate	19-50	interleukin 2	Homo sapiens	159-163
2878123-8	1986	The phorbol ester, phorbol 12-myristate 13-acetate (PMA) in combination with phytohemagglutinin or concanavalin A, were required for maximal release of LT and IL-2.	Tetradecanoylphorbol Acetate	52-55	interleukin 2	Homo sapiens	159-163
2878123-10	1986	Soluble anti-CD3 was not sufficient to induce IL-2 or LT release from the II-23 hybrid; however, soluble anti-CD3 combined with PMA was a strong stimulus for lymphotoxin and IL-2 release.	Tetradecanoylphorbol Acetate	128-131	interleukin 2	Homo sapiens	174-178
3489545-5	1986	Cytochalasins not only increased IL-2 release, but could substitute for phorbol myristic acetate (PMA) in supporting mitogen-signaled IL-2 production.	Tetradecanoylphorbol Acetate	98-101	interleukin 2	Homo sapiens	134-138
3490935-6	1986	However, impaired IL-2 production could be partly restored by either (1) adding PMA to the PHA-stimulated culture, or (2) supplementing indomethacin (IM) from the initiation of the culture, or (3) depletion of adherent cells from PBMC.	Tetradecanoylphorbol Acetate	80-83	interleukin 2	Homo sapiens	18-22
2426266-10	1986	Treatment of hepatocytes with PMA likewise inhibits the ability of vasopressin, angiotensin II, and alpha 1-adrenergic agonists to increase IP3 and mobilize Ca2+ (Lynch, C. J., Charest, R., Bocckino, S. B., Exton, J. H., and Blackmore, P. F. (1985) J. Biol.	Tetradecanoylphorbol Acetate	30-33	arginine vasopressin	Homo sapiens	67-78
2426266-10	1986	Treatment of hepatocytes with PMA likewise inhibits the ability of vasopressin, angiotensin II, and alpha 1-adrenergic agonists to increase IP3 and mobilize Ca2+ (Lynch, C. J., Charest, R., Bocckino, S. B., Exton, J. H., and Blackmore, P. F. (1985) J. Biol.	Tetradecanoylphorbol Acetate	30-33	angiotensinogen	Homo sapiens	80-94
3530763-1	1986	One of the early effects of the phorbol ester tumor promoter 12-0-tetradecanoylphorbol-13-acetate (TPA) on cultured normal fibroblasts is the release of fibronectin into the culture medium.	Tetradecanoylphorbol Acetate	99-102	fibronectin 1	Homo sapiens	153-164
3740256-8	1986	The amounts of prolactin synthesized by cells exposed to diC8 (300 microM) or PMA (10(-7) M) for 30 min were 56.3 and 50.0% less than that synthesized by control cells (P less than 0.01 in each instance).	Tetradecanoylphorbol Acetate	78-81	prolactin	Homo sapiens	15-24
3740256-6	1986	Phorbol 12-myristate 13-acetate (PMA), phorbol 12,13-didecanoate, and 4 beta-phorbol 12,13-dibutyrate, which activate protein kinase C in other systems, also inhibited the release of prolactin, while the protein kinase C inactivate 4 alpha-phorbol-12,13-didecanoate was without effect.	Tetradecanoylphorbol Acetate	0-31	prolactin	Homo sapiens	183-192
3740256-6	1986	Phorbol 12-myristate 13-acetate (PMA), phorbol 12,13-didecanoate, and 4 beta-phorbol 12,13-dibutyrate, which activate protein kinase C in other systems, also inhibited the release of prolactin, while the protein kinase C inactivate 4 alpha-phorbol-12,13-didecanoate was without effect.	Tetradecanoylphorbol Acetate	33-36	prolactin	Homo sapiens	183-192
3093404-5	1986	Addition of a calcium ionophore (A23187) to cultures containing TPA plus PRL increased ornithine decarboxylase above PRL alone or PRL plus TPA but inhibited proliferation compared to the PRL plus TPA regimen.	Tetradecanoylphorbol Acetate	64-67	prolactin	Rattus norvegicus	117-120
3093404-4	1986	TPA enhanced PRL-stimulated Nb2 node lymphoma cell ornithine decarboxylase induction and [3H]thymidine incorporation.	Tetradecanoylphorbol Acetate	0-3	prolactin	Rattus norvegicus	13-16
3530763-2	1986	Immunophotoelectron microscopy was used to follow the loss of fibronectin from the upper cell surface of normal human foreskin fibroblasts exposed to TPA.	Tetradecanoylphorbol Acetate	150-153	fibronectin 1	Homo sapiens	62-73
3093404-5	1986	Addition of a calcium ionophore (A23187) to cultures containing TPA plus PRL increased ornithine decarboxylase above PRL alone or PRL plus TPA but inhibited proliferation compared to the PRL plus TPA regimen.	Tetradecanoylphorbol Acetate	64-67	prolactin	Rattus norvegicus	117-120
3093404-5	1986	Addition of a calcium ionophore (A23187) to cultures containing TPA plus PRL increased ornithine decarboxylase above PRL alone or PRL plus TPA but inhibited proliferation compared to the PRL plus TPA regimen.	Tetradecanoylphorbol Acetate	64-67	prolactin	Rattus norvegicus	117-120
3530763-5	1986	Ten to 30 min of exposure to 100 ng/ml TPA in culture medium results in a readily visible decrease in upper cell surface fibronectin.	Tetradecanoylphorbol Acetate	39-42	fibronectin 1	Homo sapiens	121-132
3093404-6	1986	Exposure of cells to TPA or TPA plus A23187 increased [3H]thymidine incorporation in a similar manner to that demonstrated for low-dose PRL.	Tetradecanoylphorbol Acetate	21-24	prolactin	Rattus norvegicus	136-139
3093404-6	1986	Exposure of cells to TPA or TPA plus A23187 increased [3H]thymidine incorporation in a similar manner to that demonstrated for low-dose PRL.	Tetradecanoylphorbol Acetate	28-31	prolactin	Rattus norvegicus	136-139
3530763-6	1986	In these experiments, 60 min of exposure to TPA releases nearly all upper cell surface fibronectin, leaving only occasional short streaks of label.	Tetradecanoylphorbol Acetate	44-47	fibronectin 1	Homo sapiens	87-98
3530763-8	1986	This immunophotoelectron study shows the distribution of fibronectin on fibroblasts at high resolution and demonstrates that the initial fibronectin release resulting from TPA exposure is at the expense of preexisting cell-surface fibronectin.	Tetradecanoylphorbol Acetate	172-175	fibronectin 1	Homo sapiens	137-148
3530763-8	1986	This immunophotoelectron study shows the distribution of fibronectin on fibroblasts at high resolution and demonstrates that the initial fibronectin release resulting from TPA exposure is at the expense of preexisting cell-surface fibronectin.	Tetradecanoylphorbol Acetate	172-175	fibronectin 1	Homo sapiens	137-148
3492504-5	1986	Both IL-3 and TPA stimulated the translocation of protein kinase C (PK-C) from the cytosol to a membrane-bound form in FDC-Mix 1 cells.	Tetradecanoylphorbol Acetate	14-17	proline rich transmembrane protein 2	Homo sapiens	50-66
3023305-1	1986	Phytohemagglutinin (PHA) and a tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) act synergistically to induce interleukin 2 (IL2) mRNA in human lymphocytes in vitro.	Tetradecanoylphorbol Acetate	62-98	interleukin 2	Homo sapiens	135-148
3023305-1	1986	Phytohemagglutinin (PHA) and a tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) act synergistically to induce interleukin 2 (IL2) mRNA in human lymphocytes in vitro.	Tetradecanoylphorbol Acetate	62-98	interleukin 2	Homo sapiens	150-153
3023305-1	1986	Phytohemagglutinin (PHA) and a tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) act synergistically to induce interleukin 2 (IL2) mRNA in human lymphocytes in vitro.	Tetradecanoylphorbol Acetate	100-103	interleukin 2	Homo sapiens	135-148
3023305-1	1986	Phytohemagglutinin (PHA) and a tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) act synergistically to induce interleukin 2 (IL2) mRNA in human lymphocytes in vitro.	Tetradecanoylphorbol Acetate	100-103	interleukin 2	Homo sapiens	150-153
3023305-7	1986	Prostaglandin E2, which is known to elevate intracellular cAMP level, also inhibited IL2 mRNA induction in the lymphocytes stimulated with PHA and TPA.	Tetradecanoylphorbol Acetate	147-150	interleukin 2	Homo sapiens	85-88
3023307-0	1986	Regulation of myeloperoxidase gene expression by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in human leukemia HL-60 cells.	Tetradecanoylphorbol Acetate	68-104	myeloperoxidase	Homo sapiens	14-29
3023307-1	1986	Myeloperoxidase synthesis during induction of differentiation of human promyelocytic leukemia HL-60 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) was studied.	Tetradecanoylphorbol Acetate	109-145	myeloperoxidase	Homo sapiens	0-15
3023307-1	1986	Myeloperoxidase synthesis during induction of differentiation of human promyelocytic leukemia HL-60 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) was studied.	Tetradecanoylphorbol Acetate	147-150	myeloperoxidase	Homo sapiens	0-15
3023307-3	1986	The cellular myeloperoxidase activity decreased early during induction of differentiation by TPA.	Tetradecanoylphorbol Acetate	93-96	myeloperoxidase	Homo sapiens	13-28
3023307-4	1986	Pulse-labeling experiments indicated that the rate of myeloperoxidase synthesis decreased to an undetectable level in cells exposed to TPA for 22 h. The relative amounts of myeloperoxidase mRNA in TPA-treated and untreated cells were determined by measuring translatable mRNA activity in a reticulocyte lysate system.	Tetradecanoylphorbol Acetate	135-138	myeloperoxidase	Homo sapiens	54-69
3023307-4	1986	Pulse-labeling experiments indicated that the rate of myeloperoxidase synthesis decreased to an undetectable level in cells exposed to TPA for 22 h. The relative amounts of myeloperoxidase mRNA in TPA-treated and untreated cells were determined by measuring translatable mRNA activity in a reticulocyte lysate system.	Tetradecanoylphorbol Acetate	135-138	myeloperoxidase	Homo sapiens	173-188
3023307-4	1986	Pulse-labeling experiments indicated that the rate of myeloperoxidase synthesis decreased to an undetectable level in cells exposed to TPA for 22 h. The relative amounts of myeloperoxidase mRNA in TPA-treated and untreated cells were determined by measuring translatable mRNA activity in a reticulocyte lysate system.	Tetradecanoylphorbol Acetate	197-200	myeloperoxidase	Homo sapiens	54-69
3023307-4	1986	Pulse-labeling experiments indicated that the rate of myeloperoxidase synthesis decreased to an undetectable level in cells exposed to TPA for 22 h. The relative amounts of myeloperoxidase mRNA in TPA-treated and untreated cells were determined by measuring translatable mRNA activity in a reticulocyte lysate system.	Tetradecanoylphorbol Acetate	197-200	myeloperoxidase	Homo sapiens	173-188
3023307-5	1986	Reduction in the myeloperoxidase mRNA level was observed as early as after 3 h treatment with TPA, and no myeloperoxidase mRNA was detected after 24 h. Time course experiments indicated that the time required for 50% reduction of myeloperoxidase mRNA in TPA-treated cells was approximately 5 h. These results suggest that TPA induces decrease of myeloperoxidase activity in HL-60 cells at a pretranslational level.	Tetradecanoylphorbol Acetate	94-97	myeloperoxidase	Homo sapiens	17-32
3023307-5	1986	Reduction in the myeloperoxidase mRNA level was observed as early as after 3 h treatment with TPA, and no myeloperoxidase mRNA was detected after 24 h. Time course experiments indicated that the time required for 50% reduction of myeloperoxidase mRNA in TPA-treated cells was approximately 5 h. These results suggest that TPA induces decrease of myeloperoxidase activity in HL-60 cells at a pretranslational level.	Tetradecanoylphorbol Acetate	254-257	myeloperoxidase	Homo sapiens	17-32
3023307-5	1986	Reduction in the myeloperoxidase mRNA level was observed as early as after 3 h treatment with TPA, and no myeloperoxidase mRNA was detected after 24 h. Time course experiments indicated that the time required for 50% reduction of myeloperoxidase mRNA in TPA-treated cells was approximately 5 h. These results suggest that TPA induces decrease of myeloperoxidase activity in HL-60 cells at a pretranslational level.	Tetradecanoylphorbol Acetate	254-257	myeloperoxidase	Homo sapiens	17-32
3016031-7	1986	With neutrophils stimulated with phorbol myristate acetate, which release very little myeloperoxidase, hydroxyl radical production was enhanced due to the additional superoxide produced by the cells.	Tetradecanoylphorbol Acetate	33-58	myeloperoxidase	Homo sapiens	86-101
3492504-5	1986	Both IL-3 and TPA stimulated the translocation of protein kinase C (PK-C) from the cytosol to a membrane-bound form in FDC-Mix 1 cells.	Tetradecanoylphorbol Acetate	14-17	proline rich transmembrane protein 2	Homo sapiens	68-72
2942536-1	1986	Thrombospondin (TSP) is a multifunctional platelet alpha-granule and extracellular matrix glycoprotein that binds specifically to plasminogen (Plg) via that protein"s lysine-binding site and modulates activation by tissue activator (TPA).	Tetradecanoylphorbol Acetate	233-236	thrombospondin 1	Homo sapiens	0-14
2942536-1	1986	Thrombospondin (TSP) is a multifunctional platelet alpha-granule and extracellular matrix glycoprotein that binds specifically to plasminogen (Plg) via that protein"s lysine-binding site and modulates activation by tissue activator (TPA).	Tetradecanoylphorbol Acetate	233-236	thrombospondin 1	Homo sapiens	16-19
3089838-0	1986	Tumour promotor 12-O-tetradecanoylphorbol 13-acetate inhibits angiotensin II-induced inositol phosphate production and cytosolic Ca2+ rise in rat renal mesangial cells.	Tetradecanoylphorbol Acetate	16-52	angiotensinogen	Rattus norvegicus	62-76
2942536-2	1986	In this study we report that the plasminogen activators, TPA and urokinase, greatly influence the binding of Plg to TSP.	Tetradecanoylphorbol Acetate	57-60	thrombospondin 1	Homo sapiens	116-119
3089838-1	1986	Preincubation of rat renal mesangial cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) strongly inhibited the increases of inositol phosphates and of free cytosolic Ca2+ induced by angiotensin II (10(-7) M).	Tetradecanoylphorbol Acetate	48-84	angiotensinogen	Rattus norvegicus	185-199
3089838-1	1986	Preincubation of rat renal mesangial cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) strongly inhibited the increases of inositol phosphates and of free cytosolic Ca2+ induced by angiotensin II (10(-7) M).	Tetradecanoylphorbol Acetate	86-89	angiotensinogen	Rattus norvegicus	185-199
3011239-5	1986	The authors have therefore also investigated the changes in enzyme pattern of B-CLL after incubation with TPA B-CLL cells are characterized by low levels of ADA, PNP, and 5"-NT, but TPA caused a marked increase in PNP activity (P less than 0.001, t test for paired samples), a pattern similar to HCL.	Tetradecanoylphorbol Acetate	182-185	purine nucleoside phosphorylase	Homo sapiens	214-217
3522591-3	1986	Treatment of quiescent H35 cells (arrested by serum starvation) with submicromolar doses of TPA resulted in a rapid and specific increase in phosphorylation of histones H2B and H1(0).	Tetradecanoylphorbol Acetate	92-95	histone cluster 1, H2bg	Rattus norvegicus	169-172
3522591-6	1986	The phosphorylation was TPA dose-dependent, with a maximum increase of approximately 14-fold for H2B, 11-fold for H1(0), and 2-fold for H4 achieved at 0.8 M TPA.	Tetradecanoylphorbol Acetate	24-27	histone cluster 1, H2bg	Rattus norvegicus	97-100
3011239-5	1986	The authors have therefore also investigated the changes in enzyme pattern of B-CLL after incubation with TPA B-CLL cells are characterized by low levels of ADA, PNP, and 5"-NT, but TPA caused a marked increase in PNP activity (P less than 0.001, t test for paired samples), a pattern similar to HCL.	Tetradecanoylphorbol Acetate	106-109	purine nucleoside phosphorylase	Homo sapiens	214-217
3017321-0	1986	Role of calcium on TPA-induced secretion of ACTH and PGE2 by pituitary cells: effect of dexamethasone.	Tetradecanoylphorbol Acetate	19-22	proopiomelanocortin	Homo sapiens	44-48
3017321-1	1986	In pituitary cells in primary culture, ACTH and PGE2 secretions can be simultaneously stimulated by TPA, in the presence of Ca2+.	Tetradecanoylphorbol Acetate	100-103	proopiomelanocortin	Homo sapiens	39-43
3017321-3	1986	Both secretions are inhibited by dexamethasone but to various extents: PGE2 release is abolished in the presence of dexamethasone whilst only 35% of the TPA-induced ACTH release is sensitive to dexamethasone.	Tetradecanoylphorbol Acetate	153-156	proopiomelanocortin	Homo sapiens	165-169
3017321-5	1986	Since PLA2-inhibition by dexamethasone is claimed to be mediated via lipocortin, these results suggest that a lipocortin-like protein is present in pituitary cells and could be involved in the TPA-induced secretions of PGE2 and ACTH.	Tetradecanoylphorbol Acetate	193-196	phospholipase A2 group IB	Homo sapiens	6-10
3017321-5	1986	Since PLA2-inhibition by dexamethasone is claimed to be mediated via lipocortin, these results suggest that a lipocortin-like protein is present in pituitary cells and could be involved in the TPA-induced secretions of PGE2 and ACTH.	Tetradecanoylphorbol Acetate	193-196	proopiomelanocortin	Homo sapiens	228-232
3758157-1	1986	A possible role for protein kinase C during the tonic phase of arterial contraction was examined in rat aorta by observing the effects of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), on angiotensin II (AII)-induced responses.	Tetradecanoylphorbol Acetate	157-193	angiotensinogen	Rattus norvegicus	204-218
3758157-1	1986	A possible role for protein kinase C during the tonic phase of arterial contraction was examined in rat aorta by observing the effects of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), on angiotensin II (AII)-induced responses.	Tetradecanoylphorbol Acetate	157-193	angiotensinogen	Rattus norvegicus	220-223
2424873-0	1986	CD 1-8 antigens on human diphtheria toxoid T lymphocyte clones: expression and modulation by TPA, sodium butyrate, and 5-azacytidine.	Tetradecanoylphorbol Acetate	93-96	integrin subunit beta 2	Homo sapiens	0-6
3522247-2	1986	The IL2 response induced by these mAb observed both in the presence and absence of phorbol myristate acetate was in the range of that obtained when Jurkat cells were stimulated with phytohemagglutinin or anti-T3 mAb (Leu 4).	Tetradecanoylphorbol Acetate	83-108	interleukin 2	Homo sapiens	4-7
2424873-8	1986	TPA greatly decreased the expression of CD3 and CD4 antigens after a 6-hr exposure.	Tetradecanoylphorbol Acetate	0-3	CD4 molecule	Homo sapiens	48-51
2424873-9	1986	Preincubation of TLC cells with TPA inhibited the mitogenic effect of anti-CD3 MoAbs on TLC cells in proliferative assays, but did not inhibit their capacity to proliferate in response to DT despite low levels of CD3 and CD4.	Tetradecanoylphorbol Acetate	32-35	CD4 molecule	Homo sapiens	221-224
3011152-5	1986	Induction of Tac antigen, a putative interleukin 2 (IL 2) receptor, was observed in two cases after cultivation with PMA or with a novel lymphokine, adult T cell leukemia-derived factor (ADF).	Tetradecanoylphorbol Acetate	117-120	interleukin 2	Homo sapiens	52-56
2941417-2	1986	IL-2 receptors on normal human T lymphocytes and the leukemic cell line, HUT102B2, are rapidly phosphorylated in vivo in response to the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	168-204	interleukin 2	Homo sapiens	0-4
2941417-2	1986	IL-2 receptors on normal human T lymphocytes and the leukemic cell line, HUT102B2, are rapidly phosphorylated in vivo in response to the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	206-209	interleukin 2	Homo sapiens	0-4
3011686-1	1986	To elucidate the biological mechanisms of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phenotypic changes in HTLV-I virus-infected human T-cell line KH-2Lo cells, inhibitors of TPA-induced ornithine decarboxylase (ODC), protein kinases and calmodulin were examined for their effects on TPA-induced multinucleated cell formation and HTLV-I p19 antigen expression.	Tetradecanoylphorbol Acetate	80-83	calmodulin 1	Homo sapiens	246-256
3011686-6	1986	On the other hand, an inhibitor of ODC, DFMO, the protein kinase inhibitors, the calmodulin inhibitor and retinoic acid suppressed TPA-induced HTLV-I p19 expression but did not suppress multinucleated cell formation.	Tetradecanoylphorbol Acetate	131-134	calmodulin 1	Homo sapiens	81-91
3729937-1	1986	In a Triton X100-extract from the particulate fraction of mouse epidermis but also of other murine tissues, the phosphorylation of a protein with the relative molecular mass of 82,000 (p82) is found to be dependent on phosphatidyl serine and the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	276-312	A kinase (PRKA) anchor protein 4	Mus musculus	185-188
3729937-1	1986	In a Triton X100-extract from the particulate fraction of mouse epidermis but also of other murine tissues, the phosphorylation of a protein with the relative molecular mass of 82,000 (p82) is found to be dependent on phosphatidyl serine and the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	314-317	A kinase (PRKA) anchor protein 4	Mus musculus	185-188
3011805-7	1986	We also show that both TPA and cAMP lead to similar increases of both major mRNA species encoded within the calcitonin gene, calcitonin itself and the neuropeptide calcitonin gene-related peptide.	Tetradecanoylphorbol Acetate	23-26	calcitonin related polypeptide alpha	Homo sapiens	108-118
3011805-7	1986	We also show that both TPA and cAMP lead to similar increases of both major mRNA species encoded within the calcitonin gene, calcitonin itself and the neuropeptide calcitonin gene-related peptide.	Tetradecanoylphorbol Acetate	23-26	calcitonin related polypeptide alpha	Homo sapiens	125-135
3011805-7	1986	We also show that both TPA and cAMP lead to similar increases of both major mRNA species encoded within the calcitonin gene, calcitonin itself and the neuropeptide calcitonin gene-related peptide.	Tetradecanoylphorbol Acetate	23-26	calcitonin related polypeptide alpha	Homo sapiens	125-135
3709811-2	1986	Glucagon and epinephrine stimulated [U-14C]palmitate oxidation to ketone bodies by 60 and 25% as early as at 1 h. The stimulatory effects were almost totally prevented by the simultaneous presence of vasopressin, phorbol 12-tetradecanoate 13-acetate (TPA), or diacylglycerol (1-oleoyl-2-acetylglycerol).	Tetradecanoylphorbol Acetate	251-254	arginine vasopressin	Homo sapiens	200-211
3015429-1	1986	The treatment of human leukemia K562 cells with 12-0-tetradecanoyl phorbol-13-acetate (TPA) caused a decrease of transferrin receptors.	Tetradecanoylphorbol Acetate	87-90	transferrin	Homo sapiens	113-124
3087408-3	1986	Treatment with 12-o-tetradecanoylphorbol-13-acetate (TPA) in vitro induced differentiation to macrophage-like cells that were strongly positive for SB, PAS, NSE, AP, CAE and NBT reduction, indicating a latent monocyte-like phenotype.	Tetradecanoylphorbol Acetate	15-51	enolase 2	Homo sapiens	157-160
3087408-3	1986	Treatment with 12-o-tetradecanoylphorbol-13-acetate (TPA) in vitro induced differentiation to macrophage-like cells that were strongly positive for SB, PAS, NSE, AP, CAE and NBT reduction, indicating a latent monocyte-like phenotype.	Tetradecanoylphorbol Acetate	53-56	enolase 2	Homo sapiens	157-160
3486042-9	1986	The observed changes in GSL patterns during PMA-induced differentiation of the CEM cells into suppressor-like cells and the inhibition of CEM cell growth by GM3 fractions suggest that the GSLs play a role in the control of cell growth and differentiation in the PMA-treated CEM cells.	Tetradecanoylphorbol Acetate	44-47	cathepsin A	Homo sapiens	24-27
3486042-9	1986	The observed changes in GSL patterns during PMA-induced differentiation of the CEM cells into suppressor-like cells and the inhibition of CEM cell growth by GM3 fractions suggest that the GSLs play a role in the control of cell growth and differentiation in the PMA-treated CEM cells.	Tetradecanoylphorbol Acetate	262-265	cathepsin A	Homo sapiens	24-27
3015429-3	1986	In cells incubated with TPA, the rate of biosynthesis of transferrin receptors was reduced to 10-20% of that in untreated cells.	Tetradecanoylphorbol Acetate	24-27	transferrin	Homo sapiens	57-68
3015429-5	1986	These results indicated that the decrease of transferrin receptors in TPA-treated cells was caused by reduced biosynthesis and accelerated degradation of the receptors.	Tetradecanoylphorbol Acetate	70-73	transferrin	Homo sapiens	45-56
3023215-4	1986	Catalase-inhibitable cytotoxicity and genetic damage were demonstrated in fibroblasts exposed to neutrophils stimulated with the irritant and tumour promoter phorbol myristate acetate or with zymosan particles.	Tetradecanoylphorbol Acetate	158-183	catalase	Homo sapiens	0-8
3708006-1	1986	Human alpha-thrombin-induced elevation of cytosolic free calcium ([Ca2+]i) and dense granule release was examined in platelets preincubated with either activators or an inhibitor of protein kinase C. 12-O-Tetradecanoylphorbol 13-acetate (TPA) or two 12-deoxy analogues of TPA, when added alone to platelets, did not elevate [Ca2+]i, as monitored by quin2 fluorescence, though small amounts of dense granule release were detected.	Tetradecanoylphorbol Acetate	200-236	coagulation factor II, thrombin	Homo sapiens	12-20
2422276-3	1986	Phorbol myristate acetate (PMA) and the ionophore A23187 cooperatively reproduced the ability of IFN-gamma to prime macrophages for tumoricidal function.	Tetradecanoylphorbol Acetate	0-25	interferon gamma	Mus musculus	97-106
2422276-3	1986	Phorbol myristate acetate (PMA) and the ionophore A23187 cooperatively reproduced the ability of IFN-gamma to prime macrophages for tumoricidal function.	Tetradecanoylphorbol Acetate	27-30	interferon gamma	Mus musculus	97-106
3085729-0	1986	The effect of tetradecanoylphorbol acetate on calcium-ion mobilization, protein phosphorylation and cytoskeletal assembly induced by thrombin or arachidonate.	Tetradecanoylphorbol Acetate	14-42	coagulation factor II, thrombin	Homo sapiens	133-141
3085729-8	1986	Longer-term preincubations with TPA differentially inhibit the secretion response induced by thrombin and arachidonate.	Tetradecanoylphorbol Acetate	32-35	coagulation factor II, thrombin	Homo sapiens	93-101
3087356-1	1986	Phorbol ester (12-O-tetradecanoyl-phorbol 13-acetate) stimulates the secretion of tissue-type plasminogen activator by the melanoma cell line, Bowes.	Tetradecanoylphorbol Acetate	15-52	plasminogen activator, tissue type	Homo sapiens	82-115
3708006-1	1986	Human alpha-thrombin-induced elevation of cytosolic free calcium ([Ca2+]i) and dense granule release was examined in platelets preincubated with either activators or an inhibitor of protein kinase C. 12-O-Tetradecanoylphorbol 13-acetate (TPA) or two 12-deoxy analogues of TPA, when added alone to platelets, did not elevate [Ca2+]i, as monitored by quin2 fluorescence, though small amounts of dense granule release were detected.	Tetradecanoylphorbol Acetate	238-241	coagulation factor II, thrombin	Homo sapiens	12-20
3708006-1	1986	Human alpha-thrombin-induced elevation of cytosolic free calcium ([Ca2+]i) and dense granule release was examined in platelets preincubated with either activators or an inhibitor of protein kinase C. 12-O-Tetradecanoylphorbol 13-acetate (TPA) or two 12-deoxy analogues of TPA, when added alone to platelets, did not elevate [Ca2+]i, as monitored by quin2 fluorescence, though small amounts of dense granule release were detected.	Tetradecanoylphorbol Acetate	272-275	coagulation factor II, thrombin	Homo sapiens	12-20
3708006-2	1986	Preincubation of the platelets with either TPA or 12-deoxyphorbol 13-phenylacetate, but not the parent, 4-beta-phorbol, produced a dose-dependent inhibition of the elevation of [Ca2+]i and 5-hydroxytryptamine release induced by human alpha-thrombin.	Tetradecanoylphorbol Acetate	43-46	coagulation factor II, thrombin	Homo sapiens	240-248
3084562-4	1986	Natural IFN-gamma in the TPA-Con A CM and rIFN-gamma (12.5-500 U/ml) induced major histocompatibility complex-class II antigens (HLA-DR, HLA-DP, and HLA-DQ) and significant lymphocyte adhesion to the EC, whereas rIFN-alpha did not.	Tetradecanoylphorbol Acetate	25-28	interferon gamma	Homo sapiens	8-17
3009492-5	1986	Treatment of SH-SY5Y cells for 4 d with 12-O-tetradecanoylphorbol-13-acetate (TPA), which resulted in morphological and functional differentiation and growth inhibition, abolished the mitogenic response to both IGF-I and II.	Tetradecanoylphorbol Acetate	40-76	insulin like growth factor 1	Homo sapiens	211-223
3009492-5	1986	Treatment of SH-SY5Y cells for 4 d with 12-O-tetradecanoylphorbol-13-acetate (TPA), which resulted in morphological and functional differentiation and growth inhibition, abolished the mitogenic response to both IGF-I and II.	Tetradecanoylphorbol Acetate	78-81	insulin like growth factor 1	Homo sapiens	211-223
3009492-7	1986	In contrast, the IGF-I binding in TPA-treated cells was only reduced to approximately 70% of the binding to control cells.	Tetradecanoylphorbol Acetate	34-37	insulin like growth factor 1	Homo sapiens	17-22
3009492-8	1986	It is therefore not excluded that the IGF-I receptor could be uncoupled by TPA, with persistent binding capacity for IGF-I.	Tetradecanoylphorbol Acetate	75-78	insulin like growth factor 1	Homo sapiens	38-43
3757051-2	1986	Untreated CM-S cells expressed a single class of high-affinity (KD = 4.5 +/- 2.3 nM) glucocorticoid receptor sites (GCr) (27,530 +/- 3752 sites/cell) as measured by a whole-cell assay at 37 degrees C using [3H]triamcinolone acetonide as tracer, while CM-S cells induced to macrophage differentiation by 10(-7) M TPA showed reduced levels of GCr (10,729 +/- 2135 sites/cell).	Tetradecanoylphorbol Acetate	312-315	nuclear receptor subfamily 3 group C member 1	Homo sapiens	85-108
3082877-2	1986	The recombinant IL-2 receptor in these cells was rapidly phosphorylated in response to phorbol myristate acetate (PMA), but its phosphorylation could not be detected in the absence of PMA or upon addition of human IL-2.	Tetradecanoylphorbol Acetate	87-112	interleukin 2	Homo sapiens	16-20
3082877-2	1986	The recombinant IL-2 receptor in these cells was rapidly phosphorylated in response to phorbol myristate acetate (PMA), but its phosphorylation could not be detected in the absence of PMA or upon addition of human IL-2.	Tetradecanoylphorbol Acetate	114-117	interleukin 2	Homo sapiens	16-20
3082877-2	1986	The recombinant IL-2 receptor in these cells was rapidly phosphorylated in response to phorbol myristate acetate (PMA), but its phosphorylation could not be detected in the absence of PMA or upon addition of human IL-2.	Tetradecanoylphorbol Acetate	184-187	interleukin 2	Homo sapiens	16-20
3539101-3	1986	Dissociation studies showed that the enhanced internalization of insulin by cells after treatment with TPA resulted from a decrease in the rate of intracellular processing of the insulin after receptor-mediated endocytosis.	Tetradecanoylphorbol Acetate	103-106	insulin	Homo sapiens	65-72
3539101-3	1986	Dissociation studies showed that the enhanced internalization of insulin by cells after treatment with TPA resulted from a decrease in the rate of intracellular processing of the insulin after receptor-mediated endocytosis.	Tetradecanoylphorbol Acetate	103-106	insulin	Homo sapiens	179-186
3539101-4	1986	The phorbol-ester-induced enhancement of internalized insulin in HepG2 cells was additive with the potentiation of endocytosed insulin induced by both the lysosomotropic reagent chloroquine and the ionophore monensin; this indicates that TPA affects the intracellular processing of the insulin receptor at a point other than those disrupted by either of these two reagents.	Tetradecanoylphorbol Acetate	238-241	insulin	Homo sapiens	54-61
3539101-4	1986	The phorbol-ester-induced enhancement of internalized insulin in HepG2 cells was additive with the potentiation of endocytosed insulin induced by both the lysosomotropic reagent chloroquine and the ionophore monensin; this indicates that TPA affects the intracellular processing of the insulin receptor at a point other than those disrupted by either of these two reagents.	Tetradecanoylphorbol Acetate	238-241	insulin	Homo sapiens	127-134
3007488-2	1986	Tumor-promoting phorbol esters (e.g. 12-O-tetradecanoyl phorbol acetate (TPA] increased the level of VL30 expression.	Tetradecanoylphorbol Acetate	37-71	RIKEN cDNA A130040M12 gene	Mus musculus	101-105
3007488-2	1986	Tumor-promoting phorbol esters (e.g. 12-O-tetradecanoyl phorbol acetate (TPA] increased the level of VL30 expression.	Tetradecanoylphorbol Acetate	73-76	RIKEN cDNA A130040M12 gene	Mus musculus	101-105
3007488-3	1986	Stimulation with either TPA or EGF produced a similar time course of VL30 expression.	Tetradecanoylphorbol Acetate	24-27	RIKEN cDNA A130040M12 gene	Mus musculus	69-73
3007488-4	1986	TPA induced VL30 expression in the EGF-receptorless NR6 cell line, indicating that neither EGF ligand-receptor binding nor phosphorylation of the EGF receptor was required for induction of VL30 expression.	Tetradecanoylphorbol Acetate	0-3	RIKEN cDNA A130040M12 gene	Mus musculus	12-16
3757051-2	1986	Untreated CM-S cells expressed a single class of high-affinity (KD = 4.5 +/- 2.3 nM) glucocorticoid receptor sites (GCr) (27,530 +/- 3752 sites/cell) as measured by a whole-cell assay at 37 degrees C using [3H]triamcinolone acetonide as tracer, while CM-S cells induced to macrophage differentiation by 10(-7) M TPA showed reduced levels of GCr (10,729 +/- 2135 sites/cell).	Tetradecanoylphorbol Acetate	312-315	nuclear receptor subfamily 3 group C member 1	Homo sapiens	116-119
3085668-4	1986	Pretreatment of the platelets with the selective protein kinase C inhibitor H7 prevents TPA induced inhibition of NaF mediated rise in [Ca++]i and TxB2 generation.	Tetradecanoylphorbol Acetate	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	114-117
3757051-4	1986	The GCr in untreated and TPA-induced cells were similar in their specificity for corticosteroids.	Tetradecanoylphorbol Acetate	25-28	nuclear receptor subfamily 3 group C member 1	Homo sapiens	4-7
3081678-2	1986	IFN-gamma mRNA levels in human neonatal blood mononuclear cells or highly purified T cells were markedly lower than those of adult cells after incubation with Con A and PMA.	Tetradecanoylphorbol Acetate	169-172	interferon gamma	Homo sapiens	0-9
3456701-1	1986	The phorbolester 12-0-tetradecanoylphorbol 13-acetate (TPA) was used for the induction of differentiation in cells of the human leukemia cell line SPI-802.	Tetradecanoylphorbol Acetate	55-58	chromogranin A	Homo sapiens	147-150
3456701-5	1986	As TPA-treated SPI-802 cells remained negative for these markers of the monocyte-macrophage complex, it can be concluded that the cells did not differentiate into monocytes and macrophages.	Tetradecanoylphorbol Acetate	3-6	chromogranin A	Homo sapiens	15-18
3456701-9	1986	In earlier studies it was found that SPI-802 cells produce hemoglobin upon exposure to TPA or hemin.	Tetradecanoylphorbol Acetate	87-90	chromogranin A	Homo sapiens	37-40
3011421-4	1986	Induction of monocytic and granulocytic differentiation of HL-60 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) and dimethylsulfoxide (DMSO) is associated with an activation of the pp60c-src tyrosine kinase, but not with increased c-src gene expression.	Tetradecanoylphorbol Acetate	74-110	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	190-195
3011421-4	1986	Induction of monocytic and granulocytic differentiation of HL-60 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) and dimethylsulfoxide (DMSO) is associated with an activation of the pp60c-src tyrosine kinase, but not with increased c-src gene expression.	Tetradecanoylphorbol Acetate	112-115	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	190-195
2419474-3	1986	The induction of IL-2 and IFN mRNAs required the synergistic action of PMA and either PHA or OKT3 mAb.	Tetradecanoylphorbol Acetate	71-74	interleukin 2	Homo sapiens	17-29
3488373-5	1986	Two monoclonal antibodies (designated as KNT-1 and KNT-2) out of six established clones reacted with natural human IL-2 molecule obtained from cultured human peripheral blood lymphocytes (PBL) stimulated with PHA-P and TPA.	Tetradecanoylphorbol Acetate	219-222	interleukin 2	Homo sapiens	115-119
3082371-1	1986	Phorbol 12-myristate 13-acetate, 1-20 nM, induced the synthesis in HeLa cells of a 65 200 Mr tissue-type plasminogen activator, and of prostaglandin E2.	Tetradecanoylphorbol Acetate	0-31	plasminogen activator, tissue type	Homo sapiens	93-126
3086215-1	1986	Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA.	Tetradecanoylphorbol Acetate	126-157	interleukin 2	Homo sapiens	208-221
3086215-1	1986	Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA.	Tetradecanoylphorbol Acetate	126-157	interleukin 2	Homo sapiens	223-227
3086215-1	1986	Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA.	Tetradecanoylphorbol Acetate	126-157	interferon gamma	Homo sapiens	233-249
3086215-1	1986	Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA.	Tetradecanoylphorbol Acetate	126-157	interferon gamma	Homo sapiens	251-260
3086215-1	1986	Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA.	Tetradecanoylphorbol Acetate	159-162	interleukin 2	Homo sapiens	208-221
3086215-1	1986	Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA.	Tetradecanoylphorbol Acetate	159-162	interleukin 2	Homo sapiens	223-227
3086215-1	1986	Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA.	Tetradecanoylphorbol Acetate	159-162	interferon gamma	Homo sapiens	233-249
3086215-1	1986	Cultures of human blood mononuclear cells incubated with the calcium ionophore A 23 187 in the presence of the tumor promoter phorbol 12-myristate-13-acetate (PMA) produced 5-10 times more of the lymphokines interleukin 2 (IL 2) and interferon-gamma (IFN-gamma) than cultures which were stimulated with other combinations of inducing agents and PMA.	Tetradecanoylphorbol Acetate	159-162	interferon gamma	Homo sapiens	251-260
3005408-4	1986	This response, which is also induced by phorbol myristate acetate and lipolysaccharide, is detectable within 1 min of mIg cross-linking and is followed within 4 min by additional translocation of PKCa to a Triton-insoluble particulate compartment.	Tetradecanoylphorbol Acetate	40-65	protein kinase C alpha	Homo sapiens	196-200
2873626-1	1986	In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) or the non-TPA-type tumor promoter, palytoxin, recombinant human insulin growth factor-I (IGF-I) and insulin synergistically stimulate prostaglandin production in rat liver cells (the C-9 cell line).	Tetradecanoylphorbol Acetate	19-55	insulin like growth factor 1	Homo sapiens	127-150
2873626-1	1986	In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) or the non-TPA-type tumor promoter, palytoxin, recombinant human insulin growth factor-I (IGF-I) and insulin synergistically stimulate prostaglandin production in rat liver cells (the C-9 cell line).	Tetradecanoylphorbol Acetate	19-55	insulin like growth factor 1	Homo sapiens	152-157
2873626-1	1986	In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) or the non-TPA-type tumor promoter, palytoxin, recombinant human insulin growth factor-I (IGF-I) and insulin synergistically stimulate prostaglandin production in rat liver cells (the C-9 cell line).	Tetradecanoylphorbol Acetate	19-55	insulin	Homo sapiens	127-134
2873626-3	1986	With both types of stimulations, prostaglandin production or deesterification, the synergistic response of the IGF-I and insulin is greater with palytoxin than with TPA.	Tetradecanoylphorbol Acetate	165-168	insulin like growth factor 1	Homo sapiens	111-116
2873626-3	1986	With both types of stimulations, prostaglandin production or deesterification, the synergistic response of the IGF-I and insulin is greater with palytoxin than with TPA.	Tetradecanoylphorbol Acetate	165-168	insulin	Homo sapiens	121-128
3005408-2	1986	Specifically, the pharmacologic PKC activator phorbol myristate acetate mimics the biologic effects of mIg cross-linking ligands, and cross-linking of membrane Ig (mIg) induces polyphosphoinositide hydrolysis generating diacylglycerol, a potent activator of PKC.	Tetradecanoylphorbol Acetate	46-71	protein kinase C alpha	Homo sapiens	32-35
3085533-2	1986	The method is based on (1) the high-affinity binding (Kp = 1.4 +/- 2 nM) of tPA to a solid-phase fibrin network constructed by thrombin proteolysis of fibrinogen covalently coupled to polyglutaraldehyde-activated polyvinyl chloride microtiter plates, and (2) the subsequent development of PA activity by the fibrin-tPA complex and its measurement with a coupled assay using a chromogenic substrate highly selective for plasmin.	Tetradecanoylphorbol Acetate	76-79	coagulation factor II, thrombin	Homo sapiens	127-135
3948333-1	1986	After application of tetradecanoylphorbol acetate to mouse skin, a decrease in the specific activity of catalase in epidermal extracts has been observed, confirming the observation of earlier workers.	Tetradecanoylphorbol Acetate	21-49	catalase	Mus musculus	104-112
2867824-1	1986	Retinoic acid (RA) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced differentiation of a human monocytic leukemia cell line, THP-1.	Tetradecanoylphorbol Acetate	23-60	GLI family zinc finger 2	Homo sapiens	132-137
2867824-1	1986	Retinoic acid (RA) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced differentiation of a human monocytic leukemia cell line, THP-1.	Tetradecanoylphorbol Acetate	62-65	GLI family zinc finger 2	Homo sapiens	132-137
2867824-7	1986	A 15-min exposure to TPA was sufficient to induce differentiation and expression of tissue transglutaminase in THP-1 cells.	Tetradecanoylphorbol Acetate	21-24	transglutaminase 2	Homo sapiens	84-107
2867824-7	1986	A 15-min exposure to TPA was sufficient to induce differentiation and expression of tissue transglutaminase in THP-1 cells.	Tetradecanoylphorbol Acetate	21-24	GLI family zinc finger 2	Homo sapiens	111-116
3513765-1	1986	Active phorbol esters such as TPA (12-0-tetra-decanoylphorbol-13-acetate) inhibited growth of mammary carcinoma cells (MCF-7 greater than BT-20 greater than MDA-MB-231 greater than = ZR-75-1 greater than HBL-100) with the exception of T-47-D cells presumably by interacting with the phospholipid/Ca2+-dependent protein kinase (PKC).	Tetradecanoylphorbol Acetate	30-33	proline rich transmembrane protein 2	Homo sapiens	327-330
3081575-10	1986	Addition of IFN alpha, 10,000-50,000 U/ml of interleukin 2 or phorbol myristate acetate (PMA) to cord mononuclear cells or of adult monocytes or PMA to cord T cells increased IFN gamma production compared to cells stimulated with concanavalin A (ConA) alone.	Tetradecanoylphorbol Acetate	62-87	interferon alpha 1	Homo sapiens	12-32
3081575-10	1986	Addition of IFN alpha, 10,000-50,000 U/ml of interleukin 2 or phorbol myristate acetate (PMA) to cord mononuclear cells or of adult monocytes or PMA to cord T cells increased IFN gamma production compared to cells stimulated with concanavalin A (ConA) alone.	Tetradecanoylphorbol Acetate	62-87	interferon gamma	Homo sapiens	175-184
3086712-9	1986	These results indicate that the phosphorylation of the 36K-Da protein of RBL-2H3 cell membranes is catalyzed by protein kinase C. H-7 also inhibited the release of serotonin from RBL-2H3 cells stimulated with an antigen or calcium ionophore A23187 and 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	252-289	RB transcriptional corepressor like 2	Rattus norvegicus	73-78
3086712-9	1986	These results indicate that the phosphorylation of the 36K-Da protein of RBL-2H3 cell membranes is catalyzed by protein kinase C. H-7 also inhibited the release of serotonin from RBL-2H3 cells stimulated with an antigen or calcium ionophore A23187 and 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	291-294	RB transcriptional corepressor like 2	Rattus norvegicus	73-78
3513765-3	1986	A rapid (30 min) TPA-dependent translocation of cytosolic PKC to membranes was found in the five TPA-sensitive cell without affecting cell growth.	Tetradecanoylphorbol Acetate	17-20	proline rich transmembrane protein 2	Homo sapiens	58-61
3513765-3	1986	A rapid (30 min) TPA-dependent translocation of cytosolic PKC to membranes was found in the five TPA-sensitive cell without affecting cell growth.	Tetradecanoylphorbol Acetate	97-100	proline rich transmembrane protein 2	Homo sapiens	58-61
3513765-6	1986	Resumption of cell growth after TPA-removal was closely related to the specific reappearance of the PKC holoenzyme activity (75K) in the TPA-responsive human mammary tumor cell lines suggesting an involvement of PKC in growth regulation.	Tetradecanoylphorbol Acetate	32-35	proline rich transmembrane protein 2	Homo sapiens	100-103
3513765-6	1986	Resumption of cell growth after TPA-removal was closely related to the specific reappearance of the PKC holoenzyme activity (75K) in the TPA-responsive human mammary tumor cell lines suggesting an involvement of PKC in growth regulation.	Tetradecanoylphorbol Acetate	32-35	proline rich transmembrane protein 2	Homo sapiens	212-215
3513765-6	1986	Resumption of cell growth after TPA-removal was closely related to the specific reappearance of the PKC holoenzyme activity (75K) in the TPA-responsive human mammary tumor cell lines suggesting an involvement of PKC in growth regulation.	Tetradecanoylphorbol Acetate	137-140	proline rich transmembrane protein 2	Homo sapiens	100-103
3513765-6	1986	Resumption of cell growth after TPA-removal was closely related to the specific reappearance of the PKC holoenzyme activity (75K) in the TPA-responsive human mammary tumor cell lines suggesting an involvement of PKC in growth regulation.	Tetradecanoylphorbol Acetate	137-140	proline rich transmembrane protein 2	Homo sapiens	212-215
3484763-9	1986	These findings indicate that signals induced by antibody 9.6 regulate IL 2 production at a pre-translational level, are operative for an extended period of time overlapping with the early phase of IL 2 mRNA accumulation, suppress IL 2 gene expression induced by PHA as well as TPA, and that antibody 9.6 and CsA exert their inhibitory effect by distinct mechanism(s).	Tetradecanoylphorbol Acetate	277-280	interleukin 2	Homo sapiens	197-201
3003196-12	1986	These results show that resident and activated macrophages express the same amount of cytochrome b, but upon stimulation with PMA, activated macrophages recruit a higher number of cytochrome b molecules in parallel with an enhanced production of O2-.	Tetradecanoylphorbol Acetate	126-129	cytochrome b, mitochondrial	Mus musculus	180-192
3484763-3	1986	Maximal levels of IL 2 mRNA were reached 6 hr after induction of Jurkat cells with a combination of mitogen phytohemagglutinin (PHA) and phorbol ester (TPA).	Tetradecanoylphorbol Acetate	152-155	interleukin 2	Homo sapiens	18-22
3017576-4	1986	A 3-day preincubation with IFN-gamma or 1 alpha,25(OH)2D3 resulted in a 5- to 10-fold increase in PMA-stimulated production of O2- as compared to cells preincubated in medium alone.	Tetradecanoylphorbol Acetate	98-101	interferon gamma	Homo sapiens	27-36
3484763-4	1986	Antibody 9.6, added during the first 4 hr after lymphocyte stimulation, markedly inhibited IL 2 mRNA accumulation induced by low but synergistic combination of PHA (5 micrograms/ml) and TPA (1.0 ng/ml).	Tetradecanoylphorbol Acetate	186-189	interleukin 2	Homo sapiens	91-95
3484763-9	1986	These findings indicate that signals induced by antibody 9.6 regulate IL 2 production at a pre-translational level, are operative for an extended period of time overlapping with the early phase of IL 2 mRNA accumulation, suppress IL 2 gene expression induced by PHA as well as TPA, and that antibody 9.6 and CsA exert their inhibitory effect by distinct mechanism(s).	Tetradecanoylphorbol Acetate	277-280	interleukin 2	Homo sapiens	70-74
3484763-9	1986	These findings indicate that signals induced by antibody 9.6 regulate IL 2 production at a pre-translational level, are operative for an extended period of time overlapping with the early phase of IL 2 mRNA accumulation, suppress IL 2 gene expression induced by PHA as well as TPA, and that antibody 9.6 and CsA exert their inhibitory effect by distinct mechanism(s).	Tetradecanoylphorbol Acetate	277-280	interleukin 2	Homo sapiens	197-201
3009424-2	1986	However, the inhibition of the differentiated phenotype of chondrocytes in TPA-treated cells is restored by parathyroid hormone (PTH), while the inhibition by retinoids is not [Takigawa et al.	Tetradecanoylphorbol Acetate	75-78	parathyroid hormone	Homo sapiens	108-127
3007165-1	1986	The enhanced expression of interleukin 2 (IL2) receptors by 12-O-tetradecanoylphorbol 13-acetate (TPA) on sublines of an Epstein-Barr virus-immortalized human B17 B cell line (M. Steinitz et al., Immunobiology 1979.	Tetradecanoylphorbol Acetate	60-96	interleukin 2	Homo sapiens	27-40
3007165-1	1986	The enhanced expression of interleukin 2 (IL2) receptors by 12-O-tetradecanoylphorbol 13-acetate (TPA) on sublines of an Epstein-Barr virus-immortalized human B17 B cell line (M. Steinitz et al., Immunobiology 1979.	Tetradecanoylphorbol Acetate	60-96	interleukin 2	Homo sapiens	42-45
3080326-5	1986	HL-60 cells treated with 100 U/ml IFN-G had an eightfold increase in expression of nonspecific esterase (NSE) and a twofold increase in H2O2 production in response to phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	167-192	interferon gamma	Homo sapiens	34-39
3080326-5	1986	HL-60 cells treated with 100 U/ml IFN-G had an eightfold increase in expression of nonspecific esterase (NSE) and a twofold increase in H2O2 production in response to phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	194-197	interferon gamma	Homo sapiens	34-39
3007165-1	1986	The enhanced expression of interleukin 2 (IL2) receptors by 12-O-tetradecanoylphorbol 13-acetate (TPA) on sublines of an Epstein-Barr virus-immortalized human B17 B cell line (M. Steinitz et al., Immunobiology 1979.	Tetradecanoylphorbol Acetate	98-101	interleukin 2	Homo sapiens	27-40
3007165-1	1986	The enhanced expression of interleukin 2 (IL2) receptors by 12-O-tetradecanoylphorbol 13-acetate (TPA) on sublines of an Epstein-Barr virus-immortalized human B17 B cell line (M. Steinitz et al., Immunobiology 1979.	Tetradecanoylphorbol Acetate	98-101	interleukin 2	Homo sapiens	42-45
3007165-5	1986	IL2-binding studies revealed that TPA induced an increase in not only the number of IL2 receptors per cell but also the affinity of the receptors for IL2.	Tetradecanoylphorbol Acetate	34-37	interleukin 2	Homo sapiens	0-3
3007165-5	1986	IL2-binding studies revealed that TPA induced an increase in not only the number of IL2 receptors per cell but also the affinity of the receptors for IL2.	Tetradecanoylphorbol Acetate	34-37	interleukin 2	Homo sapiens	84-87
3007165-5	1986	IL2-binding studies revealed that TPA induced an increase in not only the number of IL2 receptors per cell but also the affinity of the receptors for IL2.	Tetradecanoylphorbol Acetate	34-37	interleukin 2	Homo sapiens	84-87
3007165-6	1986	The number and affinity of IL2 receptors on the C76 subline treated with TPA appear to be similar to those of activated normal human peripheral T cells.	Tetradecanoylphorbol Acetate	73-76	interleukin 2	Homo sapiens	27-30
3006669-1	1986	Addition of 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) to A431 human epidermoid carcinoma cells causes a marked increase in the phosphorylation state of the epidermal growth factor (EGF) receptor with a concomitant inhibition of both the high-affinity binding of 125I-EGF and the receptor tyrosine kinase activity.	Tetradecanoylphorbol Acetate	63-66	epidermal growth factor receptor	Homo sapiens	170-208
3006036-1	1986	The effects of the tumor promoter phorbol 12-tetradecanoate 13-acetate (TPA) on the epidermal growth factor (EGF) receptor levels were investigated in hormone-dependent (MCF-7, T-47-D, and ZR-75-1) and hormone-independent (MDA-MB-231, HBL-100, and BT-20) human mammary carcinoma cell lines.	Tetradecanoylphorbol Acetate	34-70	epidermal growth factor receptor	Homo sapiens	84-122
3006036-1	1986	The effects of the tumor promoter phorbol 12-tetradecanoate 13-acetate (TPA) on the epidermal growth factor (EGF) receptor levels were investigated in hormone-dependent (MCF-7, T-47-D, and ZR-75-1) and hormone-independent (MDA-MB-231, HBL-100, and BT-20) human mammary carcinoma cell lines.	Tetradecanoylphorbol Acetate	72-75	epidermal growth factor receptor	Homo sapiens	84-122
3004469-0	1986	Reversal by protein kinase C inhibitor of suppressive actions of phorbol-12-myristate-13-acetate on polyphosphoinositide metabolism and cytosolic Ca2+ mobilization in thrombin-stimulated human platelets.	Tetradecanoylphorbol Acetate	65-96	coagulation factor II, thrombin	Homo sapiens	167-175
3004469-2	1986	The H-7 reversal of the inhibitory action of PMA was also observed in thrombin-induced polyphosphoinositide breakdown by phospholipase C. These results provide additional support to the developing theory that the inhibition of PMA on Ca2+ mobilization and phosphoinositide turnover may be mediated by protein kinase C activation.	Tetradecanoylphorbol Acetate	45-48	coagulation factor II, thrombin	Homo sapiens	70-78
3004469-2	1986	The H-7 reversal of the inhibitory action of PMA was also observed in thrombin-induced polyphosphoinositide breakdown by phospholipase C. These results provide additional support to the developing theory that the inhibition of PMA on Ca2+ mobilization and phosphoinositide turnover may be mediated by protein kinase C activation.	Tetradecanoylphorbol Acetate	227-230	coagulation factor II, thrombin	Homo sapiens	70-78
3001178-2	1986	Interleukin 2 (IL 2) production by these lines can be induced by phytohemagglutinin (PHA), T3 antibodies, or calcium ionophores, but only in combination with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	158-183	interleukin 2	Homo sapiens	0-13
3001088-10	1986	Very similar results, including similar peptide maps, were obtained for the insulin-like growth factor I receptor from cells treated with TPA and insulin-like growth factor I.	Tetradecanoylphorbol Acetate	138-141	insulin like growth factor 1	Homo sapiens	76-104
3014952-4	1986	SOD inhibits 60 to 75% of spontaneous CL and 91 to 93% of PMA-induced CL.	Tetradecanoylphorbol Acetate	58-61	superoxide dismutase 1	Homo sapiens	0-3
3489679-3	1986	Addition of phorbol myristate acetate to the cultures resulted in enhancement of IL 2 production, but there was no significant promotion when indomethacin or human lymphoblastoid cell lines were added to the cultures.	Tetradecanoylphorbol Acetate	12-37	interleukin 2	Homo sapiens	81-85
3571848-4	1986	Human neutrophils stimulated in vitro with phorbol myristate acetate released 32.6% and 53% of their content in myeloperoxidase (an azurophilic granule marker) and vitamin B12 binding activity, respectively.	Tetradecanoylphorbol Acetate	43-68	myeloperoxidase	Homo sapiens	112-127
3004435-2	1986	Treatment of cytoplasts with phorbol myristate acetate, a potent activator of neutrophil functions, triggers translocation of PK-C from the cytosol to the plasma membrane, with an activity recovery of 83 +/- 16%.	Tetradecanoylphorbol Acetate	29-54	proline rich transmembrane protein 2	Homo sapiens	126-130
3083761-9	1986	The antigen-exogenous IL2-driven pathway of HILDA production by clones was bypassed by use of either PMA or calcium ionophore (CaI) alone or associated in the culture.	Tetradecanoylphorbol Acetate	101-104	interleukin 2	Homo sapiens	22-25
3001178-2	1986	Interleukin 2 (IL 2) production by these lines can be induced by phytohemagglutinin (PHA), T3 antibodies, or calcium ionophores, but only in combination with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	158-183	interleukin 2	Homo sapiens	15-19
3001178-2	1986	Interleukin 2 (IL 2) production by these lines can be induced by phytohemagglutinin (PHA), T3 antibodies, or calcium ionophores, but only in combination with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	185-188	interleukin 2	Homo sapiens	0-13
3001178-2	1986	Interleukin 2 (IL 2) production by these lines can be induced by phytohemagglutinin (PHA), T3 antibodies, or calcium ionophores, but only in combination with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	185-188	interleukin 2	Homo sapiens	15-19
3097429-1	1986	Absolute capacity for IL2 production by human peripheral blood mononuclear cells (PBMC) was studied using 12-O-tetradecanoylphorbol 13-acetate (TPA) and calcium ionophore A23187, which act synergistically, to induce lymphokine synthesis.	Tetradecanoylphorbol Acetate	106-142	interleukin 2	Homo sapiens	22-25
3097429-1	1986	Absolute capacity for IL2 production by human peripheral blood mononuclear cells (PBMC) was studied using 12-O-tetradecanoylphorbol 13-acetate (TPA) and calcium ionophore A23187, which act synergistically, to induce lymphokine synthesis.	Tetradecanoylphorbol Acetate	144-147	interleukin 2	Homo sapiens	22-25
3099098-7	1986	The changes in PK-C activity in TPA + RA-treated cells were accompanied by Ca2+/phospholipid(PL)-dependent phosphorylation in vitro of pp38 which is characteristic of treatment with RA alone, as well as the Ca2+/PL-independent phosphorylation in vitro of pp82 and pp130 (vinculin) which is prevalent in cells treated continuously with TPA alone and is absent in RA-treated cells.	Tetradecanoylphorbol Acetate	335-338	proline rich transmembrane protein 2	Homo sapiens	15-19
3099098-8	1986	These results indicate that the macrophage phenotype induced by TPA + RA is similar to that produced by continuous exposure to TPA alone with respect to their in vitro phosphoprotein patterns, cytochemical markers, cell adherence and morphology, but that the disappearance of PK-C is not an obligatory characteristic of these cells.	Tetradecanoylphorbol Acetate	64-67	proline rich transmembrane protein 2	Homo sapiens	276-280
3762216-5	1986	Phosphorylation of various cell lysate proteins (p18, p21, p29, p34 and p45) were also stimulated by TPA.	Tetradecanoylphorbol Acetate	101-104	alpha- and gamma-adaptin binding protein	Mus musculus	64-67
3097429-2	1986	Culture parameters were optimized for the TPA/A23187 stimulation such that maximal IL2 titers were produced with a high degree of reproducibility.	Tetradecanoylphorbol Acetate	42-45	interleukin 2	Homo sapiens	83-86
3097429-3	1986	Thus, using a synthetic medium, TPA/A23187 at 20/50ng/ml respectively, and a cell concentration of 2.5 X 10(6)/ml, IL2 titers in the cultures increased linearly over a period of 96h, reaching values at least 15-fold higher than with lectin stimulation.	Tetradecanoylphorbol Acetate	32-35	interleukin 2	Homo sapiens	115-118
3099098-5	1986	Protein kinase C (PK-C) activity was increased 35-40% in cells treated for 1 h with TPA alone or after subsequent exposure to RA.	Tetradecanoylphorbol Acetate	84-87	proline rich transmembrane protein 2	Homo sapiens	0-16
3099098-5	1986	Protein kinase C (PK-C) activity was increased 35-40% in cells treated for 1 h with TPA alone or after subsequent exposure to RA.	Tetradecanoylphorbol Acetate	84-87	proline rich transmembrane protein 2	Homo sapiens	18-22
3099098-6	1986	Cells treated for 48 h with RA exhibited a 2-fold increase in PK-C activity while cells exposed to TPA for 48 h lost all PK-C activity.	Tetradecanoylphorbol Acetate	99-102	proline rich transmembrane protein 2	Homo sapiens	121-125
3099098-7	1986	The changes in PK-C activity in TPA + RA-treated cells were accompanied by Ca2+/phospholipid(PL)-dependent phosphorylation in vitro of pp38 which is characteristic of treatment with RA alone, as well as the Ca2+/PL-independent phosphorylation in vitro of pp82 and pp130 (vinculin) which is prevalent in cells treated continuously with TPA alone and is absent in RA-treated cells.	Tetradecanoylphorbol Acetate	32-35	proline rich transmembrane protein 2	Homo sapiens	15-19
3864781-3	1985	Incubation of homogeneous esterase 1 with 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) at either 4 or 37 degrees C for up to 18 h yielded phorbol 13 alpha-acetate as the only hydrolysis product.	Tetradecanoylphorbol Acetate	93-96	carboxylesterase 1C	Mus musculus	26-36
3091996-2	1986	The IL 2 production could be greatly augmented by the addition of a phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	83-120	interleukin 2	Homo sapiens	4-8
3091996-2	1986	The IL 2 production could be greatly augmented by the addition of a phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	122-125	interleukin 2	Homo sapiens	4-8
3091996-6	1986	Remarkable IL 2 production was also induced by OKT3 when latex beads coated with rabbit anti-mouse IgG2a antibody and TPA were added to the culture.	Tetradecanoylphorbol Acetate	118-121	interleukin 2	Homo sapiens	11-15
3099131-3	1986	Using this improved method we demonstrated that reagents such as 12-O-tetradecanoylphorbol-13-acetate (TPA), concanavalin A (Con A) and a calcium ionophore (A23187) could induce the expression of IFN-gamma gene of a human T-lymphoblastoid cell line, TCL-Fuj 2M, where TPA functioned synergistically with Con A and A23187.	Tetradecanoylphorbol Acetate	65-101	interferon gamma	Homo sapiens	196-205
3099131-3	1986	Using this improved method we demonstrated that reagents such as 12-O-tetradecanoylphorbol-13-acetate (TPA), concanavalin A (Con A) and a calcium ionophore (A23187) could induce the expression of IFN-gamma gene of a human T-lymphoblastoid cell line, TCL-Fuj 2M, where TPA functioned synergistically with Con A and A23187.	Tetradecanoylphorbol Acetate	103-106	interferon gamma	Homo sapiens	196-205
3099131-3	1986	Using this improved method we demonstrated that reagents such as 12-O-tetradecanoylphorbol-13-acetate (TPA), concanavalin A (Con A) and a calcium ionophore (A23187) could induce the expression of IFN-gamma gene of a human T-lymphoblastoid cell line, TCL-Fuj 2M, where TPA functioned synergistically with Con A and A23187.	Tetradecanoylphorbol Acetate	268-271	interferon gamma	Homo sapiens	196-205
2867449-1	1985	Since prolactin, like the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate, induces ornithine decarboxylase and plasminogen activator activities, biochemical markers of a trophic response, this hormone might likewise promote neoplasia.	Tetradecanoylphorbol Acetate	41-78	prolactin	Rattus norvegicus	6-15
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Tetradecanoylphorbol Acetate	58-61	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	84-103
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Tetradecanoylphorbol Acetate	58-61	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	191-206
3002355-1	1985	The hydro-osmotic response of the toad urinary bladder to antidiuretic hormone (ADH) and cyclic AMP was inhibited by phorbol myristate acetate (PMA) and 4 beta- phorbol dideconate (4 beta-PDD), activators of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	117-142	arginine vasopressin	Homo sapiens	58-78
3002355-1	1985	The hydro-osmotic response of the toad urinary bladder to antidiuretic hormone (ADH) and cyclic AMP was inhibited by phorbol myristate acetate (PMA) and 4 beta- phorbol dideconate (4 beta-PDD), activators of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	117-142	arginine vasopressin	Homo sapiens	80-83
3002355-1	1985	The hydro-osmotic response of the toad urinary bladder to antidiuretic hormone (ADH) and cyclic AMP was inhibited by phorbol myristate acetate (PMA) and 4 beta- phorbol dideconate (4 beta-PDD), activators of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	144-147	arginine vasopressin	Homo sapiens	58-78
3002355-1	1985	The hydro-osmotic response of the toad urinary bladder to antidiuretic hormone (ADH) and cyclic AMP was inhibited by phorbol myristate acetate (PMA) and 4 beta- phorbol dideconate (4 beta-PDD), activators of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	144-147	arginine vasopressin	Homo sapiens	80-83
3864781-7	1985	Phorbol 12-myristate, phorbol 12,13-dibutyrate, and PMA were found to be competitive inhibitors of the beta-alanine-nitrophenyl esterase activity of esterase 1 with Ki values of approximately 7 microM.	Tetradecanoylphorbol Acetate	52-55	carboxylesterase 1C	Mus musculus	149-159
4063970-2	1985	In this paper, we describe that PKC translocation was a general phenomenon in all PKC containing cell types when five 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive and nonresponsive hematopoietic tumor cell lines were investigated.	Tetradecanoylphorbol Acetate	118-154	proline rich transmembrane protein 2	Homo sapiens	32-35
4063970-2	1985	In this paper, we describe that PKC translocation was a general phenomenon in all PKC containing cell types when five 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive and nonresponsive hematopoietic tumor cell lines were investigated.	Tetradecanoylphorbol Acetate	118-154	proline rich transmembrane protein 2	Homo sapiens	82-85
3002691-4	1985	In addition, T cells cultured with VIT3 plus TPA but not with VIT3 or TPA alone express high levels of interleukin 2 (IL-2) receptors and transferrin receptors.	Tetradecanoylphorbol Acetate	45-48	interleukin 2	Homo sapiens	103-116
3002691-4	1985	In addition, T cells cultured with VIT3 plus TPA but not with VIT3 or TPA alone express high levels of interleukin 2 (IL-2) receptors and transferrin receptors.	Tetradecanoylphorbol Acetate	45-48	interleukin 2	Homo sapiens	118-122
2932270-10	1985	The addition of PHA or PHA plus TPA led to an increase in IL-2 production.	Tetradecanoylphorbol Acetate	32-35	interleukin 2	Homo sapiens	58-62
4063970-2	1985	In this paper, we describe that PKC translocation was a general phenomenon in all PKC containing cell types when five 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive and nonresponsive hematopoietic tumor cell lines were investigated.	Tetradecanoylphorbol Acetate	156-159	proline rich transmembrane protein 2	Homo sapiens	32-35
4063970-2	1985	In this paper, we describe that PKC translocation was a general phenomenon in all PKC containing cell types when five 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive and nonresponsive hematopoietic tumor cell lines were investigated.	Tetradecanoylphorbol Acetate	156-159	proline rich transmembrane protein 2	Homo sapiens	82-85
4063970-5	1985	By contrast, PKC translocation and TPA induced proliferation inhibition exhibited a similar dose dependence in a subline of U-937 (U-937 RES) adapted to growth in the presence of 10(-9) M TPA.	Tetradecanoylphorbol Acetate	188-191	proline rich transmembrane protein 2	Homo sapiens	13-16
3009354-8	1985	On the contrary, fMLP- or PMA-stimulated myeloperoxidase release by fMLP or PMA was enhanced by 30% and 150%, respectively, following treatment with 6-aminonicotinamide, suggesting a decreased oxidative inactivation of myeloperoxidase.	Tetradecanoylphorbol Acetate	26-29	myeloperoxidase	Homo sapiens	41-56
3936721-2	1985	A tumor-promoting phorbol ester, 12-O-tetradecanoyl-phorbol 13-acetate (TPA), acted synergistically with a Ca2+ ionophore A23187 or phytohemagglutinin (PHA) to induce a high level of IL2 mRNA in lymphocytes, whereas each of them by itself could not induce the mRNA production.	Tetradecanoylphorbol Acetate	33-70	interleukin 2	Homo sapiens	183-186
3936721-2	1985	A tumor-promoting phorbol ester, 12-O-tetradecanoyl-phorbol 13-acetate (TPA), acted synergistically with a Ca2+ ionophore A23187 or phytohemagglutinin (PHA) to induce a high level of IL2 mRNA in lymphocytes, whereas each of them by itself could not induce the mRNA production.	Tetradecanoylphorbol Acetate	72-75	interleukin 2	Homo sapiens	183-186
3936721-3	1985	In two-step culture experiments the lymphocytes pulse-incubated with TPA for 1 h (the first culture) could efficiently initiate IL2 mRNA production by subsequent culture with A23187 or PHA (the second culture).	Tetradecanoylphorbol Acetate	69-72	interleukin 2	Homo sapiens	128-131
3936721-7	1985	These results show that mobilization of Ca2+ and the calmodulin-dependent regulatory system appear to work synergistically with TPA which probably activates protein kinase C in the pathway to IL2 gene expression.	Tetradecanoylphorbol Acetate	128-131	interleukin 2	Homo sapiens	192-195
3009354-1	1985	Stimulation of polymorphonuclear leukocytes with phorbol myristate acetate (PMA) or chemotactic factors such as f-Met-Leu-Phe (fMLP) activates a membrane oxidase which results in the generation of the superoxide anion (O2-) and the oxidation of NADPH to NADP+.	Tetradecanoylphorbol Acetate	49-74	formyl peptide receptor 1	Homo sapiens	127-131
3009354-8	1985	On the contrary, fMLP- or PMA-stimulated myeloperoxidase release by fMLP or PMA was enhanced by 30% and 150%, respectively, following treatment with 6-aminonicotinamide, suggesting a decreased oxidative inactivation of myeloperoxidase.	Tetradecanoylphorbol Acetate	26-29	formyl peptide receptor 1	Homo sapiens	68-72
3009354-8	1985	On the contrary, fMLP- or PMA-stimulated myeloperoxidase release by fMLP or PMA was enhanced by 30% and 150%, respectively, following treatment with 6-aminonicotinamide, suggesting a decreased oxidative inactivation of myeloperoxidase.	Tetradecanoylphorbol Acetate	26-29	myeloperoxidase	Homo sapiens	219-234
4077988-4	1985	Phorbol myristate acetate, phorbol dibutyrate, and 4-beta-phorbol-12,13-didecanoate (10(-5) M) each caused striking secretory responses at 5 h with accumulation of Na+, K+, Cl-, and HCO3- intraluminally.	Tetradecanoylphorbol Acetate	0-25	HCO3	Sus scrofa	182-186
3005248-10	1985	These results indicated that TPA treatment of mitogen-activated human lymphocytes stimulated the phosphorylation of transferrin receptors, but TPA had no effect on the expression of the receptors thereafter.	Tetradecanoylphorbol Acetate	29-32	transferrin	Homo sapiens	116-127
3005250-5	1985	W-7, known to be an inhibitor of both Ca2+-activated phospholipid-dependent protein kinase (C-kinase) and calmodulin, inhibited the degranulation induced by OAG or PMA, while it inhibited the reaction induced by A23187 less markedly.	Tetradecanoylphorbol Acetate	164-167	calmodulin 1	Homo sapiens	92-116
3937226-6	1985	Phorbol myristic acetate (PMA) at non-mitogenic concentrations exerted an extremely strong synergistic effect on A23187-induced cell proliferation, which was, again, mediated via an IL-2-dependent pathway.	Tetradecanoylphorbol Acetate	26-29	interleukin 2	Homo sapiens	182-186
3934268-6	1985	Combination of the ionophore with PMA induced the occurrence of Tac and further increased the expression of transferrin receptor and HLA-DR. A23187 similarly enhanced the PMA-mediated increase in cell size.	Tetradecanoylphorbol Acetate	34-37	transferrin	Homo sapiens	108-119
3934268-6	1985	Combination of the ionophore with PMA induced the occurrence of Tac and further increased the expression of transferrin receptor and HLA-DR. A23187 similarly enhanced the PMA-mediated increase in cell size.	Tetradecanoylphorbol Acetate	171-174	transferrin	Homo sapiens	108-119
3001700-4	1985	The phorbol ester 4 beta-phorbol 12-myristate 13-acetate also stimulates EGF receptor RNA accumulation.	Tetradecanoylphorbol Acetate	20-56	epidermal growth factor receptor	Homo sapiens	73-85
3937226-8	1985	Combination of PMA and A23187 resulted in considerable IL-2 production.	Tetradecanoylphorbol Acetate	15-18	interleukin 2	Homo sapiens	55-59
2997197-4	1985	In addition, pretreatment of VSMC with either PMA (IC50 approximately 1 nM) or 1-oleoyl-2-acetylglycerol (IC50 approximately 7.5 microM) also markedly inhibits angiotensin II (1 nM)-stimulated increases in cytosolic free Ca2+, as measured with the calcium-sensitive fluorescent indicator quin 2, or 45Ca2+ efflux.	Tetradecanoylphorbol Acetate	46-49	angiotensinogen	Rattus norvegicus	160-174
4063581-1	1985	The effects of the co-carcinogenic phorbol ester, phorbol myristate acetate (PMA), on N-formyl-Met-Leu-Phe (FMLP)-induced human polymorphonuclear leukocyte chemokinesis and release of granular lysozyme and beta-glucuronidase were compared with those of the inactive phorbol didecanoate (PDD).	Tetradecanoylphorbol Acetate	50-75	formyl peptide receptor 1	Homo sapiens	86-106
2416313-1	1985	The effects of dibutyryl cAMP (Bt2cAMP) and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol-12,13-didecanoate (PDD) on VIP/PHM-27 gene expression in human neuroblastoma cells in culture were investigated.	Tetradecanoylphorbol Acetate	67-103	vasoactive intestinal peptide	Homo sapiens	149-152
2416313-1	1985	The effects of dibutyryl cAMP (Bt2cAMP) and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol-12,13-didecanoate (PDD) on VIP/PHM-27 gene expression in human neuroblastoma cells in culture were investigated.	Tetradecanoylphorbol Acetate	67-103	vasoactive intestinal peptide	Homo sapiens	153-159
4075102-3	1985	Here we report that a known tumor-promoting phorbol diester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), can support the survival of both neuronal types in the absence of either NGF or CNTF and does so with the same efficacy as the corresponding trophic factor.	Tetradecanoylphorbol Acetate	61-98	nerve growth factor	Gallus gallus	179-182
4063581-1	1985	The effects of the co-carcinogenic phorbol ester, phorbol myristate acetate (PMA), on N-formyl-Met-Leu-Phe (FMLP)-induced human polymorphonuclear leukocyte chemokinesis and release of granular lysozyme and beta-glucuronidase were compared with those of the inactive phorbol didecanoate (PDD).	Tetradecanoylphorbol Acetate	50-75	formyl peptide receptor 1	Homo sapiens	108-112
4075102-3	1985	Here we report that a known tumor-promoting phorbol diester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), can support the survival of both neuronal types in the absence of either NGF or CNTF and does so with the same efficacy as the corresponding trophic factor.	Tetradecanoylphorbol Acetate	61-98	ciliary neurotrophic factor	Gallus gallus	186-190
4075102-3	1985	Here we report that a known tumor-promoting phorbol diester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), can support the survival of both neuronal types in the absence of either NGF or CNTF and does so with the same efficacy as the corresponding trophic factor.	Tetradecanoylphorbol Acetate	100-103	ciliary neurotrophic factor	Gallus gallus	186-190
4063581-1	1985	The effects of the co-carcinogenic phorbol ester, phorbol myristate acetate (PMA), on N-formyl-Met-Leu-Phe (FMLP)-induced human polymorphonuclear leukocyte chemokinesis and release of granular lysozyme and beta-glucuronidase were compared with those of the inactive phorbol didecanoate (PDD).	Tetradecanoylphorbol Acetate	77-80	formyl peptide receptor 1	Homo sapiens	86-106
4063581-1	1985	The effects of the co-carcinogenic phorbol ester, phorbol myristate acetate (PMA), on N-formyl-Met-Leu-Phe (FMLP)-induced human polymorphonuclear leukocyte chemokinesis and release of granular lysozyme and beta-glucuronidase were compared with those of the inactive phorbol didecanoate (PDD).	Tetradecanoylphorbol Acetate	77-80	formyl peptide receptor 1	Homo sapiens	108-112
4063581-4	1985	PMA also inhibited the FMLP-induced increase in cytoplasmic calcium level, measured by the fluorescent indicator quin-2.	Tetradecanoylphorbol Acetate	0-3	formyl peptide receptor 1	Homo sapiens	23-27
3930496-8	1985	Thus, the potentiation of arachidonic acid release by PMA appeared to be due to phospholipase A2 activity.	Tetradecanoylphorbol Acetate	54-57	phospholipase A2 group IB	Homo sapiens	80-96
3862668-2	1985	Induction was due to increased uPA-mRNA levels which rose from 10 to 300 molecules/cell within 2 h of exposure to 16 nM phorbol myristate acetate.	Tetradecanoylphorbol Acetate	120-145	plasminogen activator, urokinase	Sus scrofa	31-34
2997433-3	1985	We found that lidocaine added to human neutrophils in vitro markedly impaired the release of superoxide anion (O2-) and the granule enzymes lysozyme and myeloperoxidase after stimulation by phorbol myristate acetate or opsonized zymosan.	Tetradecanoylphorbol Acetate	190-215	myeloperoxidase	Homo sapiens	153-168
3930485-6	1985	In the presence of increased intracellular calcium levels, the effects of 12-O-tetradecanoyl phorbol 13-acetate on prolactin gene transcription are quantitatively identical to those observed in response to TRH or EGF.	Tetradecanoylphorbol Acetate	74-111	prolactin	Rattus norvegicus	115-124
4041372-4	1985	It is concluded: (1) peroxidase-positive U-937 cells are monoblasts and promonocytes involved in myeloperoxidase synthesis; (2) TPA-stimulation caricatures transformation of these cells into monocytes but not into resident macrophages, as far as peroxidase cytochemistry is concerned; (3) the reactivity of myeloperoxidase present in the endoplasmic reticulum of synthesizing cells is inhibited by glutaraldehyde fixation.	Tetradecanoylphorbol Acetate	128-131	myeloperoxidase	Homo sapiens	97-112
4041372-4	1985	It is concluded: (1) peroxidase-positive U-937 cells are monoblasts and promonocytes involved in myeloperoxidase synthesis; (2) TPA-stimulation caricatures transformation of these cells into monocytes but not into resident macrophages, as far as peroxidase cytochemistry is concerned; (3) the reactivity of myeloperoxidase present in the endoplasmic reticulum of synthesizing cells is inhibited by glutaraldehyde fixation.	Tetradecanoylphorbol Acetate	128-131	myeloperoxidase	Homo sapiens	307-322
3861770-1	1985	An oligodendroglial specific property, glucocorticoid regulation of glycerol-3-phosphate dehydrogenase (GPDH) levels, was inhibited in C6 rat glioma cells when 4 beta-phorbol 12-myristate 13-acetate (PMA) was added to the cultures.	Tetradecanoylphorbol Acetate	162-198	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	68-102
3861770-1	1985	An oligodendroglial specific property, glucocorticoid regulation of glycerol-3-phosphate dehydrogenase (GPDH) levels, was inhibited in C6 rat glioma cells when 4 beta-phorbol 12-myristate 13-acetate (PMA) was added to the cultures.	Tetradecanoylphorbol Acetate	162-198	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	104-108
3861770-1	1985	An oligodendroglial specific property, glucocorticoid regulation of glycerol-3-phosphate dehydrogenase (GPDH) levels, was inhibited in C6 rat glioma cells when 4 beta-phorbol 12-myristate 13-acetate (PMA) was added to the cultures.	Tetradecanoylphorbol Acetate	200-203	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	68-102
3861770-1	1985	An oligodendroglial specific property, glucocorticoid regulation of glycerol-3-phosphate dehydrogenase (GPDH) levels, was inhibited in C6 rat glioma cells when 4 beta-phorbol 12-myristate 13-acetate (PMA) was added to the cultures.	Tetradecanoylphorbol Acetate	200-203	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	104-108
3938026-1	1985	Phytohemagglutinin (PHA), picibanil (OK432) and tumor promoting agent (TPA) were tested in various combinations for optimal induction of human interferon-gamma (HuIFN-gamma).	Tetradecanoylphorbol Acetate	71-74	interferon gamma	Homo sapiens	143-159
2864925-4	1985	Our results demonstrate that TPA will not only inhibit the insulin stimulated increase in tyrosine aminotransferase, but will also inhibit induction of the enzyme by glucocorticoids or by cAMP.	Tetradecanoylphorbol Acetate	29-32	insulin	Homo sapiens	59-66
2415144-5	1985	New data are reviewed which suggest that a putative wound hormone TGF-beta has similar differential effects on normal and transformed epithelial cells to those of TPA.	Tetradecanoylphorbol Acetate	163-166	transforming growth factor beta 1	Homo sapiens	66-74
3930891-5	1985	IL 2 had the ability to restore lytic activity to PMA-treated cells but did not induce IFN gamma production.	Tetradecanoylphorbol Acetate	50-53	interleukin 2	Homo sapiens	0-4
2992637-3	1985	By contrast, after stimulation with phytohemagglutinin (PHA) or with PHA plus 12-O-tetradecanoylphorbol-13-acetate, the production of IL 2 and IFN-gamma by B-CLL T lymphocytes was similar to that of normal T lymphocytes, irrespective of the reversed T lymphocyte subset distribution (OKT4/OKT8 ratio) observed in B-CLL.	Tetradecanoylphorbol Acetate	78-114	interleukin 2	Homo sapiens	134-138
3161562-3	1985	The receptors for IL 2, which were initially absent from the cell surface, were induced on high percentages of the ALL cells after the in vitro exposure to the lectin phytohemagglutinin or the phorbol ester 12-O-tetradecanoylphorbol-13-acetate in six patients, suggesting that the cells had become sensitive to IL 2.	Tetradecanoylphorbol Acetate	207-243	interleukin 2	Homo sapiens	18-22
3161562-3	1985	The receptors for IL 2, which were initially absent from the cell surface, were induced on high percentages of the ALL cells after the in vitro exposure to the lectin phytohemagglutinin or the phorbol ester 12-O-tetradecanoylphorbol-13-acetate in six patients, suggesting that the cells had become sensitive to IL 2.	Tetradecanoylphorbol Acetate	207-243	interleukin 2	Homo sapiens	311-315
3161893-1	1985	mRNA specific for tissue type plasminogen activator (t-PA) is induced in HeLa cells by the tumor promoter phorbol myristate acetate (Waller, E.K., and Schleuning, W.D.	Tetradecanoylphorbol Acetate	106-131	plasminogen activator, tissue type	Homo sapiens	18-51
3161893-1	1985	mRNA specific for tissue type plasminogen activator (t-PA) is induced in HeLa cells by the tumor promoter phorbol myristate acetate (Waller, E.K., and Schleuning, W.D.	Tetradecanoylphorbol Acetate	106-131	plasminogen activator, tissue type	Homo sapiens	53-57
2992637-3	1985	By contrast, after stimulation with phytohemagglutinin (PHA) or with PHA plus 12-O-tetradecanoylphorbol-13-acetate, the production of IL 2 and IFN-gamma by B-CLL T lymphocytes was similar to that of normal T lymphocytes, irrespective of the reversed T lymphocyte subset distribution (OKT4/OKT8 ratio) observed in B-CLL.	Tetradecanoylphorbol Acetate	78-114	interferon gamma	Homo sapiens	143-152
3875683-8	1985	This mutant, termed JA3 (surface phenotype: T11+, T3+, 3A1+, T4-, T8-, DR-, Tac-, 4F2+, T44+) produced large amounts of IL-2 upon stimulation with PHA, anti-T3, or anticlonotypic mAb in conjunction with phorbol myristate acetate (or adherent cells).	Tetradecanoylphorbol Acetate	203-228	interleukin 2	Homo sapiens	120-124
3935348-1	1985	The effect of phytohaemagglutinin (PHA) and/or phorbol myristic acetate (PMA) on human interferon-gamma (HuIFN-gamma) and interleukin 2 (IL-2) production was measured in peripheral blood leucocytes (PBL) from multiple sclerosis (MS) patients.	Tetradecanoylphorbol Acetate	73-76	interferon gamma	Homo sapiens	87-103
2995443-0	1985	Inhibition of vasopressin-stimulated water flow in toad bladder by phorbol myristate acetate, dioctanoylglycerol, and RHC-80267.	Tetradecanoylphorbol Acetate	67-92	arginine vasopressin	Homo sapiens	14-25
3926889-8	1985	Treatment of cells with subinducing doses of Con A or phorbol myristate acetate increased IFN-gamma induction by exogenous IL 2.	Tetradecanoylphorbol Acetate	54-79	interferon gamma	Homo sapiens	90-99
3926889-8	1985	Treatment of cells with subinducing doses of Con A or phorbol myristate acetate increased IFN-gamma induction by exogenous IL 2.	Tetradecanoylphorbol Acetate	54-79	interleukin 2	Homo sapiens	123-127
2989289-5	1985	Stimulation of neutrophils with phorbol myristate acetate (PMA, 100 ng/ml) plus azide (5 mM) for 30 min completely inactivated intragranular myeloperoxidase and reduced cytosolic catalase to 35% of resting cells.	Tetradecanoylphorbol Acetate	32-57	myeloperoxidase	Homo sapiens	141-156
2992392-0	1985	Coregulation of collagenase and collagenase inhibitor production by phorbol myristate acetate in human skin fibroblasts.	Tetradecanoylphorbol Acetate	68-93	TIMP metallopeptidase inhibitor 1	Homo sapiens	32-53
2992392-1	1985	Phorbol myristate acetate (PMA), a tumor promotor known to stimulate collagenase production in fibroblasts and endothelial cells, was examined with regard to its ability to regulate the expression of the collagenase inhibitor secreted by human skin fibroblasts.	Tetradecanoylphorbol Acetate	0-25	TIMP metallopeptidase inhibitor 1	Homo sapiens	204-225
2992392-1	1985	Phorbol myristate acetate (PMA), a tumor promotor known to stimulate collagenase production in fibroblasts and endothelial cells, was examined with regard to its ability to regulate the expression of the collagenase inhibitor secreted by human skin fibroblasts.	Tetradecanoylphorbol Acetate	27-30	TIMP metallopeptidase inhibitor 1	Homo sapiens	204-225
2992392-3	1985	PMA stimulated the production of both collagenase and collagenase inhibitor in several cell lines to maximal rates that were very similar, 300 to 350 vs 230 to 330 pmol 10 micrograms DNA-1 48 h-1, respectively.	Tetradecanoylphorbol Acetate	0-3	TIMP metallopeptidase inhibitor 1	Homo sapiens	54-75
2991920-4	1985	However, upon exposure to 1,25-dihydroxyvitamin D3 or phorbol esters (PMA), both of which promote monocytic differentiation of HL60, these cells synthesized and released CI in a dose-dependent manner.	Tetradecanoylphorbol Acetate	70-73	TIMP metallopeptidase inhibitor 1	Homo sapiens	170-172
2992477-3	1985	TPA decreased the glucocorticoid receptor activity and augmented the cGMP content of subconfluent fibroblasts.	Tetradecanoylphorbol Acetate	0-3	nuclear receptor subfamily 3 group C member 1	Homo sapiens	18-41
2992482-6	1985	Additionally, TPA and TCD both induced a high density of cell surface receptors for interleukin 2 (IL2) and transferrin, but not synthesis or production of IL2.	Tetradecanoylphorbol Acetate	14-17	interleukin 2	Homo sapiens	84-97
2992482-6	1985	Additionally, TPA and TCD both induced a high density of cell surface receptors for interleukin 2 (IL2) and transferrin, but not synthesis or production of IL2.	Tetradecanoylphorbol Acetate	14-17	interleukin 2	Homo sapiens	99-102
2992482-6	1985	Additionally, TPA and TCD both induced a high density of cell surface receptors for interleukin 2 (IL2) and transferrin, but not synthesis or production of IL2.	Tetradecanoylphorbol Acetate	14-17	transferrin	Homo sapiens	108-119
2989289-11	1985	In contrast, myeloperoxidase in normal polymorphonuclear leukocytes stimulated with PMA in the presence of azide and GSH-GSH peroxidase was 75% inactivated.	Tetradecanoylphorbol Acetate	84-87	myeloperoxidase	Homo sapiens	13-28
2410377-2	1985	JA3 had been selected because of its ability to release large amounts of IL-2 following stimulation with phytohemagglutinin (PHA) or anti-T3 antibody in the presence of phorbolmyristate acetate (PMA).	Tetradecanoylphorbol Acetate	169-193	interleukin 2	Homo sapiens	73-77
3874870-9	1985	TPA, which also causes differentiation in these cells, and the synthetic diacylglycerol, 1-oleoyl-2-acetylglycerol, have opposite effects from LPS on both phosphatidylinositol turnover and cellular Ca+ mobilization.	Tetradecanoylphorbol Acetate	0-3	toll-like receptor 4	Mus musculus	143-146
3161502-3	1985	12-O-tetradecanoyl phorbol-13-acetate and 1-oleoyl-2-acetyl-sn-glycerol stimulated PRL release throughout a range of Ca2+ concentrations (1 nM -3 microM), but stimulation was greater at higher Ca2+ concentrations (.1 microM to 1 microM).	Tetradecanoylphorbol Acetate	0-37	prolactin	Rattus norvegicus	83-86
3874867-6	1985	Incubation of platelets with a stimulus for protein kinase C, 12-O-tetradecanoyl phorbol 13-acetate, prior to the addition of thrombin impairs the hydrolysis of PIP2 and the increase in IP3, with 50% inhibition occurring at 60 nM TPA.	Tetradecanoylphorbol Acetate	230-233	coagulation factor II, thrombin	Homo sapiens	126-134
2989289-5	1985	Stimulation of neutrophils with phorbol myristate acetate (PMA, 100 ng/ml) plus azide (5 mM) for 30 min completely inactivated intragranular myeloperoxidase and reduced cytosolic catalase to 35% of resting cells.	Tetradecanoylphorbol Acetate	32-57	catalase	Homo sapiens	179-187
2989289-5	1985	Stimulation of neutrophils with phorbol myristate acetate (PMA, 100 ng/ml) plus azide (5 mM) for 30 min completely inactivated intragranular myeloperoxidase and reduced cytosolic catalase to 35% of resting cells.	Tetradecanoylphorbol Acetate	59-62	myeloperoxidase	Homo sapiens	141-156
2989289-5	1985	Stimulation of neutrophils with phorbol myristate acetate (PMA, 100 ng/ml) plus azide (5 mM) for 30 min completely inactivated intragranular myeloperoxidase and reduced cytosolic catalase to 35% of resting cells.	Tetradecanoylphorbol Acetate	59-62	catalase	Homo sapiens	179-187
3890983-7	1985	Exposure of U-937 to phorbol diester (TPA) under conditions that induce features of macrophage differentiation (including the expression of Mo1) results in a significant reduction in Mb1 expression.	Tetradecanoylphorbol Acetate	38-41	CD79a molecule	Homo sapiens	183-186
3927900-5	1985	In A-549 human lung carcinoma cells, TGF-beta, but not TGF-alpha, stimulated arachidonic acid metabolism synergistically with TPA.	Tetradecanoylphorbol Acetate	126-129	transforming growth factor beta 1	Homo sapiens	37-45
2412841-7	1985	The phorbol ester, TPA, released histamine in a dose-dependent manner and this response was inhibited by SP-A.	Tetradecanoylphorbol Acetate	19-22	surfactant protein A1	Rattus norvegicus	105-109
3874078-7	1985	Furthermore, two stimuli (IL 1 and phorbol myristate acetate), which are able to replace monocytes at the level of IL2 production, also induce responsiveness to IL2 under accessory cell-dependent conditions.	Tetradecanoylphorbol Acetate	35-60	interleukin 2	Homo sapiens	161-164
3874078-7	1985	Furthermore, two stimuli (IL 1 and phorbol myristate acetate), which are able to replace monocytes at the level of IL2 production, also induce responsiveness to IL2 under accessory cell-dependent conditions.	Tetradecanoylphorbol Acetate	35-60	interleukin 2	Homo sapiens	115-118
4006322-1	1985	We report here that the chemotactic peptide, N-formyl-methionyl-leucyl-phenylalanine (FMLP), and the mitogenic phorbol ester, phorbol myristate acetate (PMA) cause a time- and concentration-dependent, selective, extracellular release of N-acetyl-beta-glucosaminidase and lysozyme from freshly isolated, adherent human peripheral blood monocytes.	Tetradecanoylphorbol Acetate	153-156	lysozyme	Homo sapiens	271-279
3876332-2	1985	A remarkable increase of IL2 mRNA was induced by stimulation with phytohemagglutinin (PHA) in the presence of 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	110-147	interleukin 2	Homo sapiens	25-28
3876332-2	1985	A remarkable increase of IL2 mRNA was induced by stimulation with phytohemagglutinin (PHA) in the presence of 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	149-152	interleukin 2	Homo sapiens	25-28
3876332-5	1985	Two-step culture experiments showed that prior exposure of the lymphocytes to TPA for 1 h at 37 degrees C resulted in a remarkable increase of IL2 mRNA on subsequent stimulation with PHA.	Tetradecanoylphorbol Acetate	78-81	interleukin 2	Homo sapiens	143-146
3876332-6	1985	This suggests that TPA induces certain changes in the biochemical pathway of signal transduction so that the cells can be triggered to express IL2 gene by subsequent stimulation with mitogen.	Tetradecanoylphorbol Acetate	19-22	interleukin 2	Homo sapiens	143-146
3857120-0	1985	Increased glucocorticoid receptor concentration in macrophage differentiation of myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	109-145	nuclear receptor subfamily 3 group C member 1	Homo sapiens	10-33
3857120-2	1985	Macrophage differentiation of HL60 cells by TPA treatment induced a 3- to 4-fold increase in glucocorticoid receptor concentration per cell and a 2- to 3-fold increase in glucocorticoid receptor concentration per mg of protein.	Tetradecanoylphorbol Acetate	44-47	nuclear receptor subfamily 3 group C member 1	Homo sapiens	93-116
3857120-2	1985	Macrophage differentiation of HL60 cells by TPA treatment induced a 3- to 4-fold increase in glucocorticoid receptor concentration per cell and a 2- to 3-fold increase in glucocorticoid receptor concentration per mg of protein.	Tetradecanoylphorbol Acetate	44-47	nuclear receptor subfamily 3 group C member 1	Homo sapiens	171-194
3857120-3	1985	The ability of TPA derivatives to increase glucocorticoid receptor concentration paralleled their ability to induce macrophage differentiation.	Tetradecanoylphorbol Acetate	15-18	nuclear receptor subfamily 3 group C member 1	Homo sapiens	43-66
3921610-1	1985	A previous study indicated that Ca++ ionophores in conjunction with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) could induce normal T lymphocytes to express receptors for the T cell growth factor, interleukin 2 (IL 2), to secrete IL 2, and to proliferate (1).	Tetradecanoylphorbol Acetate	124-127	interleukin 2	Homo sapiens	192-212
3857120-4	1985	Macrophage differentiation of other myeloid leukemia cells by TPA treatment induced a 2- to 3-fold increase in glucocorticoid receptor concentration per cell.	Tetradecanoylphorbol Acetate	62-65	nuclear receptor subfamily 3 group C member 1	Homo sapiens	111-134
3857120-7	1985	The increase in glucocorticoid receptor concentration in macrophage differentiation of myeloid leukemia cells with TPA was considered to depend, not on TPA treatment, but on the process of macrophage differentiation.	Tetradecanoylphorbol Acetate	115-118	nuclear receptor subfamily 3 group C member 1	Homo sapiens	16-39
3857120-7	1985	The increase in glucocorticoid receptor concentration in macrophage differentiation of myeloid leukemia cells with TPA was considered to depend, not on TPA treatment, but on the process of macrophage differentiation.	Tetradecanoylphorbol Acetate	152-155	nuclear receptor subfamily 3 group C member 1	Homo sapiens	16-39
3158511-3	1985	Like insulin, TPA provoked rapid increases in 2-deoxyglucose transport and pyruvate dehydrogenase activity in mature insulin-responsive BC3H-1 cultured myocytes.	Tetradecanoylphorbol Acetate	14-17	insulin	Homo sapiens	117-124
3158511-4	1985	TPA also stimulated amino acid uptake, as evidenced by uptake of alpha-methylaminoisobutyric acid; the relatively slow time course of this effect paralleled that of insulin.	Tetradecanoylphorbol Acetate	0-3	insulin	Homo sapiens	165-172
3158511-6	1985	The insulin-like effects in the myocytes appeared to be specific for TPA, the biologically active phorbol diester which activates protein kinase C, as other tested phorbol derivatives were without effect.	Tetradecanoylphorbol Acetate	69-72	insulin	Homo sapiens	4-11
3158511-9	1985	Since insulin rapidly increases diacylglycerol levels in these cells, and TPA mimics diacylglycerol biochemically, it is possible that insulin may control cellular processes through changes in diacylglycerol.	Tetradecanoylphorbol Acetate	74-77	insulin	Homo sapiens	135-142
3159820-8	1985	T cell activation with mAb 9.3 and TPA was associated with increases in interleukin 2(IL-2) receptor expression and IL-2 secretion.	Tetradecanoylphorbol Acetate	35-38	interleukin 2	Homo sapiens	86-90
3159820-8	1985	T cell activation with mAb 9.3 and TPA was associated with increases in interleukin 2(IL-2) receptor expression and IL-2 secretion.	Tetradecanoylphorbol Acetate	35-38	interleukin 2	Homo sapiens	116-120
2988800-1	1985	When human erythroleukemia cells (K562) were exposed to phorbol-12-myristate 13-acetate (PMA), phosphorylation of transferrin receptors was enhanced 5-fold with 10(-7) M PMA and 7-fold with 10(-6) M PMA, but not with 4 alpha-phorbol (5 X 10(-7) M).	Tetradecanoylphorbol Acetate	56-87	transferrin	Homo sapiens	114-125
2988800-1	1985	When human erythroleukemia cells (K562) were exposed to phorbol-12-myristate 13-acetate (PMA), phosphorylation of transferrin receptors was enhanced 5-fold with 10(-7) M PMA and 7-fold with 10(-6) M PMA, but not with 4 alpha-phorbol (5 X 10(-7) M).	Tetradecanoylphorbol Acetate	89-92	transferrin	Homo sapiens	114-125
2988800-1	1985	When human erythroleukemia cells (K562) were exposed to phorbol-12-myristate 13-acetate (PMA), phosphorylation of transferrin receptors was enhanced 5-fold with 10(-7) M PMA and 7-fold with 10(-6) M PMA, but not with 4 alpha-phorbol (5 X 10(-7) M).	Tetradecanoylphorbol Acetate	170-173	transferrin	Homo sapiens	114-125
2988800-1	1985	When human erythroleukemia cells (K562) were exposed to phorbol-12-myristate 13-acetate (PMA), phosphorylation of transferrin receptors was enhanced 5-fold with 10(-7) M PMA and 7-fold with 10(-6) M PMA, but not with 4 alpha-phorbol (5 X 10(-7) M).	Tetradecanoylphorbol Acetate	170-173	transferrin	Homo sapiens	114-125
3921610-4	1985	The Ca++ ionophore ionomycin and TPA, used in conjunction, mimicked the effect of specific alloantigen on these T cell clones, i.e., they induced the secretion of IFN-gamma in all clones and the secretion of IL 2 in the T4+ clone.	Tetradecanoylphorbol Acetate	33-36	interferon gamma	Homo sapiens	163-172
3921610-4	1985	The Ca++ ionophore ionomycin and TPA, used in conjunction, mimicked the effect of specific alloantigen on these T cell clones, i.e., they induced the secretion of IFN-gamma in all clones and the secretion of IL 2 in the T4+ clone.	Tetradecanoylphorbol Acetate	33-36	interleukin 2	Homo sapiens	208-212
3921610-6	1985	Increased sensitivity to exogenous IL 2 for some T cell clones was also observed after either alloantigen or ionomycin and TPA treatment; this could be correlated with an increase in the expression of IL 2 receptors 6 hr after a pulse with ionomycin and TPA.	Tetradecanoylphorbol Acetate	123-126	interleukin 2	Homo sapiens	35-39
3921610-6	1985	Increased sensitivity to exogenous IL 2 for some T cell clones was also observed after either alloantigen or ionomycin and TPA treatment; this could be correlated with an increase in the expression of IL 2 receptors 6 hr after a pulse with ionomycin and TPA.	Tetradecanoylphorbol Acetate	254-257	interleukin 2	Homo sapiens	35-39
3921610-6	1985	Increased sensitivity to exogenous IL 2 for some T cell clones was also observed after either alloantigen or ionomycin and TPA treatment; this could be correlated with an increase in the expression of IL 2 receptors 6 hr after a pulse with ionomycin and TPA.	Tetradecanoylphorbol Acetate	254-257	interleukin 2	Homo sapiens	201-205
3921610-1	1985	A previous study indicated that Ca++ ionophores in conjunction with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) could induce normal T lymphocytes to express receptors for the T cell growth factor, interleukin 2 (IL 2), to secrete IL 2, and to proliferate (1).	Tetradecanoylphorbol Acetate	124-127	interleukin 2	Homo sapiens	214-227
3921610-1	1985	A previous study indicated that Ca++ ionophores in conjunction with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) could induce normal T lymphocytes to express receptors for the T cell growth factor, interleukin 2 (IL 2), to secrete IL 2, and to proliferate (1).	Tetradecanoylphorbol Acetate	124-127	interleukin 2	Homo sapiens	229-233
3921610-1	1985	A previous study indicated that Ca++ ionophores in conjunction with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) could induce normal T lymphocytes to express receptors for the T cell growth factor, interleukin 2 (IL 2), to secrete IL 2, and to proliferate (1).	Tetradecanoylphorbol Acetate	124-127	interleukin 2	Homo sapiens	247-251
4033659-0	1985	Collagen expression in embryonic chicken chondrocytes treated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	67-92	collagen type III alpha 1 chain	Gallus gallus	0-8
3858662-4	1985	Furthermore, we demonstrate that phorbol ester (12-O-tetradecanoylphorbol-13-acetate; TPA) inhibits the effects of ara-C on heme production, accumulation of globin RNA, and glycophorin expression.	Tetradecanoylphorbol Acetate	48-84	plasminogen activator, tissue type	Homo sapiens	86-89
4039726-2	1985	The highly increased fibrinolytic activity of HeLa cells, treated with the tumor promoting phorbol ester, phorbol myristate acetate (PMA), correlates with equally increased levels of tissue-type plasminogen activator (t-PA) antigen in the conditioned media of these cells and concomitantly increased steady state levels of t-PA-specific mRNA.	Tetradecanoylphorbol Acetate	106-131	plasminogen activator, tissue type	Homo sapiens	183-216
4080962-1	1985	The authors tested TPA in association with CEA in colon rectal, breast and stomach cancer.	Tetradecanoylphorbol Acetate	19-22	CEA cell adhesion molecule 3	Homo sapiens	43-46
2987951-0	1985	Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.	Tetradecanoylphorbol Acetate	0-25	coagulation factor II, thrombin	Homo sapiens	35-43
2987951-1	1985	The tumor-promoting phorbol diester 4 beta-phorbol 12-myristate 13-acetate (PMA) inhibited mobilization of intracellular Ca2+ in platelets by thrombin (also trypsin and 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine).	Tetradecanoylphorbol Acetate	38-74	coagulation factor II, thrombin	Homo sapiens	142-150
2987951-1	1985	The tumor-promoting phorbol diester 4 beta-phorbol 12-myristate 13-acetate (PMA) inhibited mobilization of intracellular Ca2+ in platelets by thrombin (also trypsin and 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine).	Tetradecanoylphorbol Acetate	76-79	coagulation factor II, thrombin	Homo sapiens	142-150
2987951-2	1985	PMA was effective over the same concentration range that activates protein kinase C in intact platelets; IC50 vs. thrombin = 2 ng/ml, 3.4 nM: greater than 90% inhibition at 10-20 ng/ml.	Tetradecanoylphorbol Acetate	0-3	coagulation factor II, thrombin	Homo sapiens	114-122
2987951-3	1985	Suppression of thrombin-induced Ca2+ mobilization was evident within 30 sec of pretreatment with PMA and was essentially complete by 6-10 min at 10-20 ng of PMA per ml.	Tetradecanoylphorbol Acetate	97-100	coagulation factor II, thrombin	Homo sapiens	15-23
2987951-3	1985	Suppression of thrombin-induced Ca2+ mobilization was evident within 30 sec of pretreatment with PMA and was essentially complete by 6-10 min at 10-20 ng of PMA per ml.	Tetradecanoylphorbol Acetate	157-160	coagulation factor II, thrombin	Homo sapiens	15-23
4039726-2	1985	The highly increased fibrinolytic activity of HeLa cells, treated with the tumor promoting phorbol ester, phorbol myristate acetate (PMA), correlates with equally increased levels of tissue-type plasminogen activator (t-PA) antigen in the conditioned media of these cells and concomitantly increased steady state levels of t-PA-specific mRNA.	Tetradecanoylphorbol Acetate	106-131	plasminogen activator, tissue type	Homo sapiens	218-222
3158820-5	1985	Phorbol myristate acetate (PMA) also induces PK-C transposition in an analogous manner, except that PMA-induced PK-C transposition to the plasma membrane is apparently protracted.	Tetradecanoylphorbol Acetate	0-25	proline rich transmembrane protein 2	Homo sapiens	45-49
4039726-2	1985	The highly increased fibrinolytic activity of HeLa cells, treated with the tumor promoting phorbol ester, phorbol myristate acetate (PMA), correlates with equally increased levels of tissue-type plasminogen activator (t-PA) antigen in the conditioned media of these cells and concomitantly increased steady state levels of t-PA-specific mRNA.	Tetradecanoylphorbol Acetate	106-131	plasminogen activator, tissue type	Homo sapiens	323-327
3158820-5	1985	Phorbol myristate acetate (PMA) also induces PK-C transposition in an analogous manner, except that PMA-induced PK-C transposition to the plasma membrane is apparently protracted.	Tetradecanoylphorbol Acetate	0-25	proline rich transmembrane protein 2	Homo sapiens	112-116
3158820-5	1985	Phorbol myristate acetate (PMA) also induces PK-C transposition in an analogous manner, except that PMA-induced PK-C transposition to the plasma membrane is apparently protracted.	Tetradecanoylphorbol Acetate	27-30	proline rich transmembrane protein 2	Homo sapiens	45-49
4039726-2	1985	The highly increased fibrinolytic activity of HeLa cells, treated with the tumor promoting phorbol ester, phorbol myristate acetate (PMA), correlates with equally increased levels of tissue-type plasminogen activator (t-PA) antigen in the conditioned media of these cells and concomitantly increased steady state levels of t-PA-specific mRNA.	Tetradecanoylphorbol Acetate	133-136	plasminogen activator, tissue type	Homo sapiens	183-216
3158820-5	1985	Phorbol myristate acetate (PMA) also induces PK-C transposition in an analogous manner, except that PMA-induced PK-C transposition to the plasma membrane is apparently protracted.	Tetradecanoylphorbol Acetate	100-103	proline rich transmembrane protein 2	Homo sapiens	112-116
4039726-2	1985	The highly increased fibrinolytic activity of HeLa cells, treated with the tumor promoting phorbol ester, phorbol myristate acetate (PMA), correlates with equally increased levels of tissue-type plasminogen activator (t-PA) antigen in the conditioned media of these cells and concomitantly increased steady state levels of t-PA-specific mRNA.	Tetradecanoylphorbol Acetate	133-136	plasminogen activator, tissue type	Homo sapiens	218-222
3158821-4	1985	Phorbol myristate acetate (PMA) is shown to have a similar effect in these IL-3-dependent FDC-P1 cells.	Tetradecanoylphorbol Acetate	0-25	interleukin 3	Mus musculus	75-79
4039726-2	1985	The highly increased fibrinolytic activity of HeLa cells, treated with the tumor promoting phorbol ester, phorbol myristate acetate (PMA), correlates with equally increased levels of tissue-type plasminogen activator (t-PA) antigen in the conditioned media of these cells and concomitantly increased steady state levels of t-PA-specific mRNA.	Tetradecanoylphorbol Acetate	133-136	plasminogen activator, tissue type	Homo sapiens	323-327
3158821-4	1985	Phorbol myristate acetate (PMA) is shown to have a similar effect in these IL-3-dependent FDC-P1 cells.	Tetradecanoylphorbol Acetate	27-30	interleukin 3	Mus musculus	75-79
2580014-0	1985	Comparison of the expression of IL 2 receptors by human T and B cells: induction by the polyclonal mitogens, phorbol myristate acetate, and anti-mu antibody.	Tetradecanoylphorbol Acetate	109-134	interleukin 2	Homo sapiens	32-36
2986464-4	1985	TPA produced two effects: a stimulation of Isc of variable magnitude and a far more constant inhibition of the natriferic action of vasopressin.	Tetradecanoylphorbol Acetate	0-3	arginine vasopressin	Homo sapiens	132-143
2986464-5	1985	These effects appear related to the action of TPA as a tumor promoter insofar as PDBU (an active ester) also inhibited the natriferic response to vasopressin, whereas phorbol (inactive as a tumor promoter) had no significant effect.	Tetradecanoylphorbol Acetate	46-49	arginine vasopressin	Homo sapiens	146-157
2986464-6	1985	TPA is largely active from the mucosal medium, inhibits the natriferic response to adenosine 3",5"-cyclic monophosphate (cAMP) as well as that to vasopressin, and does not stimulate Isc in the presence of 10(-4) M mucosal amiloride.	Tetradecanoylphorbol Acetate	0-3	arginine vasopressin	Homo sapiens	146-157
3859320-1	1985	We have investigated the control of lysozyme gene expression in HL-60 cells induced to differentiate into macrophage-like cells with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	133-158	lysozyme	Homo sapiens	36-44
3859320-1	1985	We have investigated the control of lysozyme gene expression in HL-60 cells induced to differentiate into macrophage-like cells with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	160-163	lysozyme	Homo sapiens	36-44
3859320-7	1985	The increase in lysozyme secretion by these cells, however, is markedly blunted suggesting that continued PMA treatment of differentiated cells is required for their secretion of lysozyme.	Tetradecanoylphorbol Acetate	106-109	lysozyme	Homo sapiens	16-24
3859320-7	1985	The increase in lysozyme secretion by these cells, however, is markedly blunted suggesting that continued PMA treatment of differentiated cells is required for their secretion of lysozyme.	Tetradecanoylphorbol Acetate	106-109	lysozyme	Homo sapiens	179-187
3156933-1	1985	Stimulation by phorbol myristate acetate enables human neutrophils to phagocytize C-reactive protein-coated cells.	Tetradecanoylphorbol Acetate	15-40	C-reactive protein	Homo sapiens	82-100
2580014-4	1985	Phorbol myristate acetate (PMA)-activated human T and small resting B cells and enhanced the expression of HLA-DR, HLA-DC/DS, and transferrin receptors while reducing Leu-4 antigen expression by T cells and IgM and IgD expression on B cells.	Tetradecanoylphorbol Acetate	0-25	transferrin	Homo sapiens	130-141
2580014-4	1985	Phorbol myristate acetate (PMA)-activated human T and small resting B cells and enhanced the expression of HLA-DR, HLA-DC/DS, and transferrin receptors while reducing Leu-4 antigen expression by T cells and IgM and IgD expression on B cells.	Tetradecanoylphorbol Acetate	27-30	transferrin	Homo sapiens	130-141
2985401-1	1985	The expression of the interleukin 2 receptor (Tac) on normal B cells and Epstein-Barr virus-transformed lymphoblastoid B cell lines is induced by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	204-207	interleukin 2	Homo sapiens	22-35
3159606-1	1985	The in vitro effect of synthetic diacylglycerol (DG) and phorbol myristate acetate (PMA), potent stimulators of protein kinase C, was studied on prolactin release.	Tetradecanoylphorbol Acetate	57-82	prolactin	Homo sapiens	145-154
3159606-1	1985	The in vitro effect of synthetic diacylglycerol (DG) and phorbol myristate acetate (PMA), potent stimulators of protein kinase C, was studied on prolactin release.	Tetradecanoylphorbol Acetate	84-87	prolactin	Homo sapiens	145-154
3159606-4	1985	The effect of Ca2+ mobilization on PMA-, synthetic DG- or phospholipase C-induced prolactin release was examined.	Tetradecanoylphorbol Acetate	35-38	prolactin	Homo sapiens	82-91
3986959-1	1985	The purpose of the experiments reported here is to improve our understanding of the mechanism whereby tumour promoters (e.g., 12-O-tetradecanoylphorbol-13-acetate, TPA) stimulate increased release of fibronectin (FN) from human lung fibroblasts (HLF) in culture.	Tetradecanoylphorbol Acetate	126-162	fibronectin 1	Homo sapiens	200-211
3986959-1	1985	The purpose of the experiments reported here is to improve our understanding of the mechanism whereby tumour promoters (e.g., 12-O-tetradecanoylphorbol-13-acetate, TPA) stimulate increased release of fibronectin (FN) from human lung fibroblasts (HLF) in culture.	Tetradecanoylphorbol Acetate	126-162	fibronectin 1	Homo sapiens	213-215
2985401-3	1985	It is functionally active so that TPA-induced B cells respond to interleukin 2 by increased DNA synthesis.	Tetradecanoylphorbol Acetate	34-37	interleukin 2	Homo sapiens	65-78
3882157-7	1985	Prolonged incubation of cultured endothelial cells after a 1-h treatment with phorbol myristate acetate resulted in an increased secretion of von Willebrand protein into the conditioned medium; in contrast, accumulation of thrombospondin and fibronectin in endothelial cell-conditioned medium was decreased.	Tetradecanoylphorbol Acetate	78-103	fibronectin 1	Homo sapiens	242-253
3920341-10	1985	TPA induced a low level of IL-2 receptor expression in monocyte-depleted T cells, without inducing IL-2 secretion.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Homo sapiens	27-31
3920341-11	1985	Anti-T3 plus TPA induced a marked enhancement in both quantity and intensity of IL-2 receptor expression.	Tetradecanoylphorbol Acetate	13-16	interleukin 2	Homo sapiens	80-84
3919020-7	1985	In contrast, pretreatment with PMA had a much smaller effect on Ca2+ mobilization induced by vasopressin.	Tetradecanoylphorbol Acetate	31-34	arginine vasopressin	Homo sapiens	93-104
2985653-9	1985	Preincubation of neutrophils with NAF resulted in greater release of superoxide anion upon their subsequent stimulation by either bacterial phagocytosis or by phorbol myristate acetate, as compared with control neutrophils stimulated in a like manner.	Tetradecanoylphorbol Acetate	159-184	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
2982848-5	1985	Secretion of TIMP was stimulated up to 10-fold by treating the cells with 20-100 ng/ml of 12-O-tetradecanoylphorbol 13-acetate or 10 units/ml of human interleukin 1.	Tetradecanoylphorbol Acetate	90-126	TIMP metallopeptidase inhibitor 1	Homo sapiens	13-17
2981919-5	1985	Furthermore, in cultures stimulated by a combination of PHA plus TPA, 9.6 did not inhibit the acquisition of IL 2 receptors but inhibited proliferation and IL 2 production.	Tetradecanoylphorbol Acetate	65-68	interleukin 2	Homo sapiens	156-160
3971047-4	1985	The tumor promoters phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDB) were shown to increase the rates of iron and transferrin uptake by reticulocytes and fetal liver erythroid cells by accelerating the rates of transferrin endocytosis and exocytosis.	Tetradecanoylphorbol Acetate	20-51	transferrin	Rattus norvegicus	138-149
3971047-4	1985	The tumor promoters phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDB) were shown to increase the rates of iron and transferrin uptake by reticulocytes and fetal liver erythroid cells by accelerating the rates of transferrin endocytosis and exocytosis.	Tetradecanoylphorbol Acetate	20-51	transferrin	Rattus norvegicus	235-246
3971047-4	1985	The tumor promoters phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDB) were shown to increase the rates of iron and transferrin uptake by reticulocytes and fetal liver erythroid cells by accelerating the rates of transferrin endocytosis and exocytosis.	Tetradecanoylphorbol Acetate	53-56	transferrin	Rattus norvegicus	138-149
3971047-4	1985	The tumor promoters phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDB) were shown to increase the rates of iron and transferrin uptake by reticulocytes and fetal liver erythroid cells by accelerating the rates of transferrin endocytosis and exocytosis.	Tetradecanoylphorbol Acetate	53-56	transferrin	Rattus norvegicus	235-246
2984122-9	1985	When PMA was tested with C5a, FMLP, or Con A, a nonadditive O2- response resulted, whereas mixtures of PMA and arachidonic acid resulted in a less than additive response.	Tetradecanoylphorbol Acetate	5-8	complement C5a receptor 1	Homo sapiens	25-28
2984122-9	1985	When PMA was tested with C5a, FMLP, or Con A, a nonadditive O2- response resulted, whereas mixtures of PMA and arachidonic acid resulted in a less than additive response.	Tetradecanoylphorbol Acetate	5-8	formyl peptide receptor 1	Homo sapiens	30-34
3156688-2	1985	[3H]TPA bound specifically to intact living HUC; maximum specific binding was attained in approximately 30 min at 37 degrees C. [3H]TPA bound to HUC in a saturable and competitive manner.	Tetradecanoylphorbol Acetate	4-7	ELAV like RNA binding protein 3	Homo sapiens	44-47
3156688-2	1985	[3H]TPA bound specifically to intact living HUC; maximum specific binding was attained in approximately 30 min at 37 degrees C. [3H]TPA bound to HUC in a saturable and competitive manner.	Tetradecanoylphorbol Acetate	4-7	ELAV like RNA binding protein 3	Homo sapiens	145-148
3156688-2	1985	[3H]TPA bound specifically to intact living HUC; maximum specific binding was attained in approximately 30 min at 37 degrees C. [3H]TPA bound to HUC in a saturable and competitive manner.	Tetradecanoylphorbol Acetate	132-135	ELAV like RNA binding protein 3	Homo sapiens	145-148
3156688-3	1985	Scatchard analysis of specific binding to intact cells displayed a single slope corresponding to an equilibrium dissociation constant (Kd) of 0.56 nM; at saturation TPA-binding capacity was 2.37 pmol/10(6) HUC (1.43 X 10(6) sites per cell).	Tetradecanoylphorbol Acetate	165-168	ELAV like RNA binding protein 3	Homo sapiens	206-209
3156688-4	1985	[3H]TPA bound specifically and with high affinity to the particulate fractions of HUC; binding was both saturable and reversible.	Tetradecanoylphorbol Acetate	4-7	ELAV like RNA binding protein 3	Homo sapiens	82-85
3156688-5	1985	Saturation of the specific binding of [3H]TPA occurred at approximately 1 nM at 4 degrees C. Scatchard analysis of specific binding to the particulate fraction displayed a single slope corresponding to a Kd of 1.08 nM; at saturation TPA-binding capacity was 2.05 pmol/mg protein (750 000 molecules per HUC).	Tetradecanoylphorbol Acetate	42-45	ELAV like RNA binding protein 3	Homo sapiens	302-305
3156688-8	1985	[3H]TPA bound specifically to the HUC cytosolic fraction but only in the presence of calcium and phosphatidylserine.	Tetradecanoylphorbol Acetate	4-7	ELAV like RNA binding protein 3	Homo sapiens	34-37
3156688-10	1985	These results indicate the presence of high-affinity specific receptors for TPA in HUC.	Tetradecanoylphorbol Acetate	76-79	ELAV like RNA binding protein 3	Homo sapiens	83-86
3921769-0	1985	Effect of serum and 12-O-tetradecanoyl-phorbol-13-acetate on FSH-stimulated conversion of 4-androstene-3,17-dione to oestrogens in cell and organ cultures of suckling mouse ovaries.	Tetradecanoylphorbol Acetate	20-57	follicle stimulating hormone beta	Mus musculus	61-64
3921769-1	1985	The effect of serum and 12-O-tetradecanoylphorbol-13-acetate (TPA) on the FSH-stimulated oestrogen production was studied in both cell and organ cultures.	Tetradecanoylphorbol Acetate	24-60	follicle stimulating hormone beta	Mus musculus	74-77
3921769-1	1985	The effect of serum and 12-O-tetradecanoylphorbol-13-acetate (TPA) on the FSH-stimulated oestrogen production was studied in both cell and organ cultures.	Tetradecanoylphorbol Acetate	62-65	follicle stimulating hormone beta	Mus musculus	74-77
3871770-2	1985	Human tumor necrosis factor (TNF) was purified to homogeneity from serum-free tissue culture supernatants of the HL-60 promyelocytic leukemia cell line induced by 4 beta-phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	165-201	tumor necrosis factor	Homo sapiens	6-27
3921769-3	1985	Either 10% serum (fetal calf, mouse, rat and horse) or 0.1 microM TPA markedly inhibited the FSH-stimulated oestrogen production by dispersed and cultured ovarian cells.	Tetradecanoylphorbol Acetate	66-69	follicle stimulating hormone beta	Mus musculus	93-96
3921769-5	1985	This suggests that the presence of tissue architecture may prevent the inhibitory effect of serum and TPA on the FSH-stimulated oestrogen production.	Tetradecanoylphorbol Acetate	102-105	follicle stimulating hormone beta	Mus musculus	113-116
3871770-2	1985	Human tumor necrosis factor (TNF) was purified to homogeneity from serum-free tissue culture supernatants of the HL-60 promyelocytic leukemia cell line induced by 4 beta-phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	165-201	tumor necrosis factor	Homo sapiens	29-32
2981271-10	1985	Thymocytes activated with TPA and Con A were more resistant to the inhibitory effects of Dex on the expression of IL 2 receptors than thymocytes activated with Con A alone.	Tetradecanoylphorbol Acetate	26-29	interleukin 2	Homo sapiens	114-118
2981586-3	1985	Recovery of B12 binding protein from neutrophils exposed to phorbol myristate acetate or opsonized zymosan was significantly enhanced on addition of heme enzyme inhibitors (azide, cyanide) or catalase or when halide-free medium was used.	Tetradecanoylphorbol Acetate	60-85	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	12-15
2981649-5	1985	Increments of cyclic AMP (cAMP) (peak: fourfold) in PGE1, PGE2, and PGD2 treated PMN stimulated with PMA or STZ (in which O2- was not reduced) were similar to those in PG-treated PMN stimulated with FMLP (in which O2- was reduced markedly).	Tetradecanoylphorbol Acetate	101-104	cathelicidin antimicrobial peptide	Homo sapiens	26-30
2981649-5	1985	Increments of cyclic AMP (cAMP) (peak: fourfold) in PGE1, PGE2, and PGD2 treated PMN stimulated with PMA or STZ (in which O2- was not reduced) were similar to those in PG-treated PMN stimulated with FMLP (in which O2- was reduced markedly).	Tetradecanoylphorbol Acetate	101-104	prostaglandin D2 synthase	Homo sapiens	68-72
3894382-4	1985	The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, was used to stimulate secretion of TIMP by human foetal lung fibroblasts and the ionophore monensin was used to demonstrate intracellular accumulation of TIMP in the Golgi apparatus of these cells.	Tetradecanoylphorbol Acetate	19-55	TIMP metallopeptidase inhibitor 1	Homo sapiens	92-96
2983703-2	1985	The antioxidants CuZn-superoxide dismutase, catalase, glutathione peroxidase and butylated-hydroxytoluene inhibit the reaction indicating that active oxygen species produced in the PMA-induced oxidative burst represent intermediates.	Tetradecanoylphorbol Acetate	181-184	catalase	Homo sapiens	44-52
2580604-4	1985	In contrast, these substances inhibited the TPA-induced increase in noradrenaline concentration and the relative activity of neuron-specific enolase.	Tetradecanoylphorbol Acetate	44-47	enolase 2	Homo sapiens	125-148
3918872-1	1985	The tumor promoter 12-O-tetradecanoylphorbol 13-acetate induces the expression of the interleukin 2 receptor and the disappearance of the T3 complex in a T cell hybridoma, T cell clones, thymic and peripheral T cells and T cell tumors.	Tetradecanoylphorbol Acetate	19-55	interleukin 2	Homo sapiens	86-99
3967682-9	1985	A TPA-responsive cell line, IAR 6-1, contained considerably less laminin-entactin than did the other lines.	Tetradecanoylphorbol Acetate	2-5	nidogen 1	Rattus norvegicus	73-81
3930011-1	1985	Tumor promoting phorbol myristate acetate (PMA) induce to enhance the expression of IL2 Receptor and to decrease the antigen receptor expression on the cell surface.	Tetradecanoylphorbol Acetate	16-41	interleukin 2	Homo sapiens	84-87
3917479-8	1985	EC IL 3 production was greatly enhanced by the addition of concanavalin A, phorbol myristate acetate, lipopolysaccharide, and silica.	Tetradecanoylphorbol Acetate	75-100	interleukin 3	Mus musculus	3-7
2982204-4	1985	Human neutrophils activated with phorbol myristate acetate disrupted calcium transport by canine cardiac sarcoplasmic reticulum, and this process was inhibited by a combination of superoxide dismutase and catalase.	Tetradecanoylphorbol Acetate	33-58	catalase	Canis lupus familiaris	205-213
3930011-1	1985	Tumor promoting phorbol myristate acetate (PMA) induce to enhance the expression of IL2 Receptor and to decrease the antigen receptor expression on the cell surface.	Tetradecanoylphorbol Acetate	43-46	interleukin 2	Homo sapiens	84-87
2981065-6	1985	Conversely, the stimulation of PRL release by phorbol myristate acetate (PMA), although significantly reduced, was not abolished by either nordihydroguaiaretic acid or BW755c.	Tetradecanoylphorbol Acetate	46-71	prolactin	Homo sapiens	31-34
3000705-10	1985	p42 is also phosphorylated in response to mitogens whose receptors lack protein-tyrosine kinase activity, for example 12-O-tetradecanoylphorbol-13-acetate (TPA) and thrombin.	Tetradecanoylphorbol Acetate	118-154	cyclin dependent kinase like 1	Homo sapiens	0-3
3000705-10	1985	p42 is also phosphorylated in response to mitogens whose receptors lack protein-tyrosine kinase activity, for example 12-O-tetradecanoylphorbol-13-acetate (TPA) and thrombin.	Tetradecanoylphorbol Acetate	156-159	cyclin dependent kinase like 1	Homo sapiens	0-3
2981065-6	1985	Conversely, the stimulation of PRL release by phorbol myristate acetate (PMA), although significantly reduced, was not abolished by either nordihydroguaiaretic acid or BW755c.	Tetradecanoylphorbol Acetate	73-76	prolactin	Homo sapiens	31-34
6335665-3	1984	A human leukemic T-cell line (Jurkat) can be induced with the lectin phytohemagglutinin and the phorbol ester tetradecanoylphorbolacetate (TPA) to produce T-cell growth factor.	Tetradecanoylphorbol Acetate	139-142	interleukin 2	Homo sapiens	155-175
2981092-0	1985	Biochemical models of gamma-interferon action: altered expression of transferrin receptors on murine peritoneal macrophages after treatment in vitro with PMA or A23187.	Tetradecanoylphorbol Acetate	154-157	interferon gamma	Mus musculus	22-38
2981092-4	1985	Saturation binding studies on thioglycollate (TG)-elicited peritoneal macrophages after exposure to A23187 or PMA showed the reduced expression of transferrin binding activity attributable to a decrease in the total number of cellular transferrin receptors and not an alteration in receptor-ligand affinity, in agreement with previous results obtained after exposure to IFN gamma.	Tetradecanoylphorbol Acetate	110-113	interferon gamma	Mus musculus	370-379
3930308-1	1985	A monoclonal antibody, AN-18.17.24, specific for murine interferon-gamma (IFN-gamma) was produced by immunizing Wistar rats with IFN-gamma secreted by a T-cell lymphoma, L12-R4, upon stimulation with phorbol myristic acetate (PMA).	Tetradecanoylphorbol Acetate	226-229	interferon gamma	Mus musculus	56-72
3930308-1	1985	A monoclonal antibody, AN-18.17.24, specific for murine interferon-gamma (IFN-gamma) was produced by immunizing Wistar rats with IFN-gamma secreted by a T-cell lymphoma, L12-R4, upon stimulation with phorbol myristic acetate (PMA).	Tetradecanoylphorbol Acetate	226-229	interferon gamma	Mus musculus	74-83
3918210-1	1985	A cloned subline of the human monocytic leukemia cell line, THP-1, was induced to produce high levels of cytotoxic activity following an 18-hour phorbol myristate acetate (CAS: 16561-29-8) stimulation in vitro.	Tetradecanoylphorbol Acetate	145-170	GLI family zinc finger 2	Homo sapiens	60-65
6439651-8	1984	Washing of these T-PLL cells to remove TPA resulted in the induction of proliferation upon subsequent culture in the presence of IL-2 or in medium only.	Tetradecanoylphorbol Acetate	39-42	interleukin 2	Homo sapiens	129-133
6335665-7	1984	Northern blot experiments with cloned TCGF DNA as a probe showed that TCGF mRNA was induced rapidly in cells treated with TPA and phytohemagglutinin, and this induction was augmented by interleukin 1.	Tetradecanoylphorbol Acetate	122-125	interleukin 2	Homo sapiens	38-42
6335665-7	1984	Northern blot experiments with cloned TCGF DNA as a probe showed that TCGF mRNA was induced rapidly in cells treated with TPA and phytohemagglutinin, and this induction was augmented by interleukin 1.	Tetradecanoylphorbol Acetate	122-125	interleukin 2	Homo sapiens	70-74
6335665-9	1984	Nuclear transcription experiments suggested that the TCGF gene was more actively transcribed in cells treated with TPA and phytohemagglutinin than in cells treated with phytohemagglutinin alone.	Tetradecanoylphorbol Acetate	115-118	interleukin 2	Homo sapiens	53-57
6335665-10	1984	The transcription of the TCGF gene was further increased when interleukin 1 was included along with TPA and phytohemagglutinin.	Tetradecanoylphorbol Acetate	100-103	interleukin 2	Homo sapiens	25-29
6436974-1	1984	The tumor promoters 12-O-tetradecanoyl-phorbol-13-acetate and teleocidin markedly enhanced the transformation of C3H 10T1/2 mouse fibroblasts when these cells were transfected with the cloned human bladder cancer c-rasH oncogene.	Tetradecanoylphorbol Acetate	20-57	asparaginase and isoaspartyl peptidase 1	Homo sapiens	213-219
6436246-5	1984	The phorbol ester 4 beta-phorbol 12-myristate 13-acetate (PMA) and the Ca2+ ionophore A23187 both bypass the phospholipid methylation and directly stimulate Ca2+ influx and von Willebrand factor release.	Tetradecanoylphorbol Acetate	20-56	von Willebrand factor	Homo sapiens	173-194
6436246-5	1984	The phorbol ester 4 beta-phorbol 12-myristate 13-acetate (PMA) and the Ca2+ ionophore A23187 both bypass the phospholipid methylation and directly stimulate Ca2+ influx and von Willebrand factor release.	Tetradecanoylphorbol Acetate	58-61	von Willebrand factor	Homo sapiens	173-194
6386832-2	1984	The synthesis of plasminogen activator is enhanced by 12-O-tetradecanoyl-phorbol-13-acetate(TPA); the increase can be followed both in the cell lysate and in the culture medium.	Tetradecanoylphorbol Acetate	54-91	plasminogen activator, tissue type	Homo sapiens	92-95
6091866-4	1984	This effect of TPA was dependent upon an inhibition of the transferrin-binding capacity as estimated on intact cells.	Tetradecanoylphorbol Acetate	15-18	transferrin	Homo sapiens	59-70
6091866-5	1984	However, experiments with transferrin binding on cell samples dissolved in 1% Triton X-100 showed that TPA-treated cells exhibited a transferrin-binding capacity similar to that of control cells.	Tetradecanoylphorbol Acetate	103-106	transferrin	Homo sapiens	26-37
6091866-5	1984	However, experiments with transferrin binding on cell samples dissolved in 1% Triton X-100 showed that TPA-treated cells exhibited a transferrin-binding capacity similar to that of control cells.	Tetradecanoylphorbol Acetate	103-106	transferrin	Homo sapiens	133-144
6091866-6	1984	On the basis of this result, it is suggested that TPA modified a part of transferrin receptors present in the cells; as a result of this modification, these receptors became unavailable for binding transferrin, but they remained physically present in the cell.	Tetradecanoylphorbol Acetate	50-53	transferrin	Homo sapiens	73-84
6091866-6	1984	On the basis of this result, it is suggested that TPA modified a part of transferrin receptors present in the cells; as a result of this modification, these receptors became unavailable for binding transferrin, but they remained physically present in the cell.	Tetradecanoylphorbol Acetate	50-53	transferrin	Homo sapiens	198-209
6091866-10	1984	However, in spite of this marked stimulation of cell proliferation, TPA-stimulated lymphocytes exhibited a transferrin-binding capacity much inferior to cells stimulated by other mitogens, such as phytohemagglutinin.	Tetradecanoylphorbol Acetate	68-71	transferrin	Homo sapiens	107-118
6237693-5	1984	Stimulation with PMA, however, resulted in significant IL-2 production.	Tetradecanoylphorbol Acetate	17-20	interleukin 2	Homo sapiens	55-59
6436256-4	1984	Epidermal growth factor and phorbol myristate acetate (PMA) also stimulated amino acid incorporation and prolactin production; absolute increases in protein synthesis provided by these agents were significantly greater in Ca2+-restored than in Ca2+-depleted preparations.	Tetradecanoylphorbol Acetate	28-53	prolactin	Rattus norvegicus	105-114
6236860-6	1984	The peak of Fn-ms binding occurred four to five days after the induction of differentiation with dimethylsulfoxide (DMSO), and two days after induction by PMA.	Tetradecanoylphorbol Acetate	155-158	fibronectin 1	Homo sapiens	12-14
6092336-4	1984	The shift in the subcellular distribution of C kinase, caused by TPA or OADG, correlated with changes in binding and phosphorylation of the EGF receptor.	Tetradecanoylphorbol Acetate	65-68	epidermal growth factor receptor	Homo sapiens	140-152
6093804-3	1984	The increase in 32P-PIP and 32P-PIP2 was 50% completed at 2 min after 10 ng/ml PMA, and was maximal by 20 min.	Tetradecanoylphorbol Acetate	79-82	prolactin induced protein	Homo sapiens	20-23
6093781-4	1984	The cytosolic level of Ca2+, determined by the fluorescence of quin-2, was elevated by TPA, and this rise required extracellular Ca2+.	Tetradecanoylphorbol Acetate	87-90	carbonic anhydrase 2	Rattus norvegicus	23-26
6237101-2	1984	Receptor-negative human T leukemic cell lines were induced to express the IL 2 receptor after incubation with 12-O-tetradecanoyl phorbol 13-acetate.	Tetradecanoylphorbol Acetate	110-147	interleukin 2	Homo sapiens	74-78
6237101-5	1984	The precursor of the IL 2 receptor isolated from tunicamycin-treated HUT102B2 or 12-O-tetradecanoyl phorbol 13-acetate-induced CCRF-CEM cells had the same Mr and isoelectric point.	Tetradecanoylphorbol Acetate	81-118	interleukin 2	Homo sapiens	21-25
6237101-6	1984	Incubation of cells with 12-O-tetradecanoyl phorbol 13-acetate also induced the rapid phosphorylation of serine and threonine residues on the IL 2 receptor from HUT102B2 cells and activated peripheral blood lymphocytes.	Tetradecanoylphorbol Acetate	25-62	interleukin 2	Homo sapiens	142-146
6488446-4	1984	Suppression of the TPA enhancement of transformation by catalase was a highly significant effect, while the suppression by SOD was not of statistical significance.	Tetradecanoylphorbol Acetate	19-22	catalase	Mus musculus	56-64
6467216-8	1984	When TPA was tested in the presence of nerve growth factor, the induction of neurite differentiation was not affected.	Tetradecanoylphorbol Acetate	5-8	nerve growth factor	Gallus gallus	39-58
6611200-2	1984	Our study investigates blastic transformation and surface antigen change on CTCL cells in vitro under the influence of tumor-promoting phorbol ester (TPA) and phytohemagglutinin.	Tetradecanoylphorbol Acetate	150-153	TSPY like 2	Homo sapiens	76-80
6090210-0	1984	Effect of the phorbol ester TPA on PTH secretion.	Tetradecanoylphorbol Acetate	28-31	parathyroid hormone	Homo sapiens	35-38
6090210-4	1984	TPA causes a dose-dependent stimulation of PTH release inhibited by high extracellular Ca2+ (EC50 = 10 nM) but has relatively little effect on secretion stimulated by low Ca2+.	Tetradecanoylphorbol Acetate	0-3	parathyroid hormone	Homo sapiens	43-46
6090210-6	1984	TPA does not modify cellular cAMP or cytosolic Ca2+ in the parathyroid cell indicating that its effects on PTH secretion are not mediated indirectly via changes in these second messengers.	Tetradecanoylphorbol Acetate	0-3	parathyroid hormone	Homo sapiens	107-110
6090210-7	1984	These results suggest that inhibition of PTH release at high Ca2+ might be related to a reduction in protein kinase C activity which can be overcome when the enzyme is directly activated by TPA.	Tetradecanoylphorbol Acetate	190-193	parathyroid hormone	Homo sapiens	41-44
6331899-10	1984	TPA was also tested for its ability to "maintain" activated T-cell blasts in a standard assay for interleukin 2 (IL-2).	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Homo sapiens	98-111
6331899-10	1984	TPA was also tested for its ability to "maintain" activated T-cell blasts in a standard assay for interleukin 2 (IL-2).	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Homo sapiens	113-117
6467686-1	1984	The chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP), per se incapable of triggering cytotoxicity, was found to significantly enhance phorbol myristate acetate (PMA)-dependent monocyte-mediated cytolysis of human red blood cell (HRBC) targets.	Tetradecanoylphorbol Acetate	152-177	formyl peptide receptor 1	Homo sapiens	65-69
6467686-1	1984	The chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP), per se incapable of triggering cytotoxicity, was found to significantly enhance phorbol myristate acetate (PMA)-dependent monocyte-mediated cytolysis of human red blood cell (HRBC) targets.	Tetradecanoylphorbol Acetate	179-182	formyl peptide receptor 1	Homo sapiens	65-69
6747295-0	1984	Effect of catalase on the proliferation of human lymphocytes to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	64-89	catalase	Homo sapiens	10-18
6747295-10	1984	The addition of catalase to PMA-treated cultures in concentrations sufficient to scavenge the H2O2 released by the monocytes was associated with an enhanced thymidine uptake (mean 79%).	Tetradecanoylphorbol Acetate	28-31	catalase	Homo sapiens	16-24
6432554-6	1984	The tumor promoters 12-O-tetradecanoyl phorbol-13-acetate and teleocidin largely reversed the inhibition by 9.6 of IFN-gamma production and metabolic activation induced by mitogens.	Tetradecanoylphorbol Acetate	20-57	interferon gamma	Homo sapiens	115-124
6430792-5	1984	PMA activation in the presence of cytochalasin B augments the release of lysozyme and initiates the release of beta glucuronidase through recruitment of the azurophilic granule but has no incremental effect on the release of vitamin B12-binding protein and histaminase observed with PMA alone.	Tetradecanoylphorbol Acetate	0-3	lysozyme	Homo sapiens	73-81
6093101-1	1984	The addition of phorbol 12-myristate 13-acetate (PMA), a potent tumor promoter, to serum-starved quiescent chicken embryo fibroblasts (CEF) or C127 murine cells resulted in increased phosphorylation of 40S ribosomal protein S6.	Tetradecanoylphorbol Acetate	16-47	ribosomal protein S6, pseudogene 4	Mus musculus	202-226
6093101-1	1984	The addition of phorbol 12-myristate 13-acetate (PMA), a potent tumor promoter, to serum-starved quiescent chicken embryo fibroblasts (CEF) or C127 murine cells resulted in increased phosphorylation of 40S ribosomal protein S6.	Tetradecanoylphorbol Acetate	49-52	ribosomal protein S6, pseudogene 4	Mus musculus	202-226
6091636-2	1984	Both 12-O-tetradecanoylphorbol 13-acetate (TPA) and EGF stimulate phosphorylation of the EGF receptor in intact human carcinoma cells.	Tetradecanoylphorbol Acetate	5-41	epidermal growth factor receptor	Homo sapiens	89-101
6091636-2	1984	Both 12-O-tetradecanoylphorbol 13-acetate (TPA) and EGF stimulate phosphorylation of the EGF receptor in intact human carcinoma cells.	Tetradecanoylphorbol Acetate	43-46	epidermal growth factor receptor	Homo sapiens	89-101
6091636-5	1984	Two-dimensional peptide mapping indicates that the two major phosphopeptides found in the 120 kDa receptor fragment correspond to the major new phosphopeptides found in intact EGF receptor following treatment with TPA.	Tetradecanoylphorbol Acetate	214-217	epidermal growth factor receptor	Homo sapiens	176-188
6091636-6	1984	Thus, the major sites of TPA-induced threonine phosphorylation reside in the 120 kDa binding domain of the EGF receptor.	Tetradecanoylphorbol Acetate	25-28	epidermal growth factor receptor	Homo sapiens	107-119
6090008-2	1984	Among the tested substances, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 12-hexadecanoyl-phorbol-13-acetate (HPA) and teleocidin induced HTLV structural protein p19 and p24.	Tetradecanoylphorbol Acetate	29-66	transmembrane p24 trafficking protein 2	Homo sapiens	170-173
6090008-2	1984	Among the tested substances, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 12-hexadecanoyl-phorbol-13-acetate (HPA) and teleocidin induced HTLV structural protein p19 and p24.	Tetradecanoylphorbol Acetate	68-71	transmembrane p24 trafficking protein 2	Homo sapiens	170-173
6208480-0	1984	Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts.	Tetradecanoylphorbol Acetate	39-75	epidermal growth factor receptor	Homo sapiens	97-129
6611200-9	1984	Blastic transformation of CTCL cells was observed with both TPA and phytohemagglutinin, but helper T-cell antigen Leu 3a (T4) and erythrocyte rosette receptor changes occurred only with TPA.	Tetradecanoylphorbol Acetate	60-63	TSPY like 2	Homo sapiens	26-30
6332315-5	1984	These studies were performed with a cloned human leukemic T-cell line (Jurkat, subclone 32), which can be induced with phytohemagglutinin and phorbol 12-myristate 13-acetate to produce large amounts of TCGF.	Tetradecanoylphorbol Acetate	142-173	interleukin 2	Homo sapiens	202-206
6733848-0	1984	Kinetics of fibronectin release from fibroblasts in response to 12-O-tetradecanoylphorbol-13-acetate and retinoic acid.	Tetradecanoylphorbol Acetate	64-100	fibronectin 1	Homo sapiens	12-23
6206645-5	1984	IFN production was enhanced by the diterpene tumor promoters, TPA and mezerein, but not by classical T-cell mitogens.	Tetradecanoylphorbol Acetate	62-65	interferon alpha 1	Homo sapiens	0-3
6611555-9	1984	IL-2 production by the patient"s phytohemagglutin-stimulated PBMC was severely deficient but was corrected by the addition of phorbol 12-myristate 13-acetate, suggesting a defective response to IL-1.	Tetradecanoylphorbol Acetate	126-157	interleukin 2	Homo sapiens	0-4
6373000-4	1984	Furthermore, the nonspecific esterase activity of TPA-treated cells and weak activity in 10% of untreated cells was strongly inhibited by NaF, a characteristic of monocytic series of cells.	Tetradecanoylphorbol Acetate	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	138-141
6733848-10	1984	We conclude that phorbol ester action and RA counteraction on the release of FN takes place on a cell-surface target; that FN which is released into the medium by TPA is derived from pre-existing FN; that RA specifically antagonizes TPA action.	Tetradecanoylphorbol Acetate	163-166	fibronectin 1	Homo sapiens	77-79
6733848-1	1984	We have studied the effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and its in vivo and in vitro antagonist retinoic acid (RA) on the synthesis and release of a major extracellular glycoprotein, fibronectin (FN), in human lung fibroblasts (HLF).	Tetradecanoylphorbol Acetate	50-86	fibronectin 1	Homo sapiens	220-231
6733848-10	1984	We conclude that phorbol ester action and RA counteraction on the release of FN takes place on a cell-surface target; that FN which is released into the medium by TPA is derived from pre-existing FN; that RA specifically antagonizes TPA action.	Tetradecanoylphorbol Acetate	163-166	fibronectin 1	Homo sapiens	123-125
6733848-10	1984	We conclude that phorbol ester action and RA counteraction on the release of FN takes place on a cell-surface target; that FN which is released into the medium by TPA is derived from pre-existing FN; that RA specifically antagonizes TPA action.	Tetradecanoylphorbol Acetate	163-166	fibronectin 1	Homo sapiens	123-125
6733848-2	1984	The studies reported here investigate the question of whether the increased amounts of FN released by TPA treatment are cell-surface derived or require de novo synthesis of FN.	Tetradecanoylphorbol Acetate	102-105	fibronectin 1	Homo sapiens	87-89
6733848-10	1984	We conclude that phorbol ester action and RA counteraction on the release of FN takes place on a cell-surface target; that FN which is released into the medium by TPA is derived from pre-existing FN; that RA specifically antagonizes TPA action.	Tetradecanoylphorbol Acetate	233-236	fibronectin 1	Homo sapiens	77-79
6733848-11	1984	No protein synthesis is required to release FN, to mediate enhanced FN release by TPA, or to counteract the enhanced release by RA.	Tetradecanoylphorbol Acetate	82-85	fibronectin 1	Homo sapiens	68-70
6733848-4	1984	Addition of TPA rapidly enhanced this release of FN into the culture medium, as shown with enzyme-linked immunosorbent assay.	Tetradecanoylphorbol Acetate	12-15	fibronectin 1	Homo sapiens	49-51
6733848-8	1984	Pre-existing (unlabeled) FN accumulated in the medium as a result of TPA treatment at a time when newly synthesized (labeled) FN was still intracellular.	Tetradecanoylphorbol Acetate	69-72	fibronectin 1	Homo sapiens	25-27
6434187-7	1984	However, PMA inhibits a subsequent CTC fluorescence response to FMLP and following the ionophore, A23187, it induces a clear decrease in cytosolic calcium.	Tetradecanoylphorbol Acetate	9-12	formyl peptide receptor 1	Homo sapiens	64-68
6431407-1	1984	Tumor promoters such as phorbol 12-tetradecanoate 13-acetate (TPA), mezerein, teleocidin, aplysiatoxin, and benzoyl peroxide, although structurally unrelated, induce similar, profound changes in morphology in differentiated epithelial Madin-Darby canine kidney (MDCK) cell colonies.	Tetradecanoylphorbol Acetate	24-60	tissue-type plasminogen activator	Canis lupus familiaris	62-65
6431408-1	1984	Monoclonal antibodies against murine immune interferon (IFN-gamma) were produced by fusing the murine nonsecreting myeloma cell line P3.X63.Ag8.653 with spleen cells from rats immunized with IFN-gamma-containing supernatants obtained by stimulating a T-cell lymphoma, L12-R4, with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	281-312	interferon gamma	Mus musculus	56-65
6431409-8	1984	Populations of monocytes incubated 3 days with 100 units of IFN-gamma per ml (0.5 nM) had enhanced capacity to produce H2O2 in response to phorbol 12-myristate 13-acetate and increased content of acid phosphatase and plasminogen activator.	Tetradecanoylphorbol Acetate	139-170	interferon gamma	Homo sapiens	60-69
6726241-0	1984	Picrotoxinin and phorbol-12-myristate-13-acetate stimulate the secretion of multiple forms of somatostatin from cultured rat brain cells.	Tetradecanoylphorbol Acetate	17-48	somatostatin	Rattus norvegicus	94-106
6234599-2	1984	Incubation of Jurkat with phytohemagglutinin (PHA) resulted in the production of interleukin 2, which was markedly increased by the addition of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	144-175	interleukin 2	Homo sapiens	81-94
6234599-2	1984	Incubation of Jurkat with phytohemagglutinin (PHA) resulted in the production of interleukin 2, which was markedly increased by the addition of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	177-180	interleukin 2	Homo sapiens	81-94
6321594-9	1984	When TPA-stimulated monocyte-mediated cytolysis was examined, catalase (2750 U/ml) inhibited K562 and U937 cytolysis by 92% and 84%, respectively; superoxide dismutase (300 U/ml) only inhibited cytotoxicity by 17% and 24%, respectively, implicating a central role of H2O2 rather than superoxide ions.	Tetradecanoylphorbol Acetate	5-8	catalase	Homo sapiens	62-70
6332111-1	1984	Various hydroxyl radical scavengers markedly inhibited phorbol myristate acetate (PMA)-induced lymphotoxin (LT) production by a human T cell hybridoma, AC5-8.	Tetradecanoylphorbol Acetate	55-80	adenylate cyclase 5	Homo sapiens	152-157
6332111-1	1984	Various hydroxyl radical scavengers markedly inhibited phorbol myristate acetate (PMA)-induced lymphotoxin (LT) production by a human T cell hybridoma, AC5-8.	Tetradecanoylphorbol Acetate	82-85	adenylate cyclase 5	Homo sapiens	152-157
6332111-5	1984	As expected, ADP-ribosyl transferase (ADPRT), which is well known to require DNA strand breaks for its enzymatic activity, was activated by PMA treatment.	Tetradecanoylphorbol Acetate	140-143	poly(ADP-ribose) polymerase 1	Homo sapiens	13-36
6332111-5	1984	As expected, ADP-ribosyl transferase (ADPRT), which is well known to require DNA strand breaks for its enzymatic activity, was activated by PMA treatment.	Tetradecanoylphorbol Acetate	140-143	poly(ADP-ribose) polymerase 1	Homo sapiens	38-43
6435182-2	1984	The synthesis of PGF by the dispersed cells incubated at 37 degrees C in serum-free medium was stimulated by estradiol (10(-7)M - 10(-5)M), histamine (5X10(-7)M - 5X10(-5)M), bradykinin (10(-6)M), phorbol myristate (PMA, 3X10(-8)M) and arachidonate (5X10(-6)M).	Tetradecanoylphorbol Acetate	216-219	placental growth factor	Homo sapiens	17-20
6609121-8	1984	One clone expressing IL-2 receptors could be induced to produce human IL-2 by simultaneously stimulating with PHA and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	118-143	interleukin 2	Homo sapiens	21-25
6609121-8	1984	One clone expressing IL-2 receptors could be induced to produce human IL-2 by simultaneously stimulating with PHA and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	118-143	interleukin 2	Homo sapiens	70-74
6609121-8	1984	One clone expressing IL-2 receptors could be induced to produce human IL-2 by simultaneously stimulating with PHA and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	145-148	interleukin 2	Homo sapiens	21-25
6609121-8	1984	One clone expressing IL-2 receptors could be induced to produce human IL-2 by simultaneously stimulating with PHA and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	145-148	interleukin 2	Homo sapiens	70-74
6327820-4	1984	In contrast, CAT and SOD effectively modulated the cytotoxicity mediated by phorbol-12-myristate-13-acetate (PMA)-activated polymorphonuclear leukocytes (PMNL) against three different tumor TC, including K562.	Tetradecanoylphorbol Acetate	76-107	superoxide dismutase 1	Homo sapiens	21-24
6327820-4	1984	In contrast, CAT and SOD effectively modulated the cytotoxicity mediated by phorbol-12-myristate-13-acetate (PMA)-activated polymorphonuclear leukocytes (PMNL) against three different tumor TC, including K562.	Tetradecanoylphorbol Acetate	109-112	superoxide dismutase 1	Homo sapiens	21-24
6327820-8	1984	PMNL, however, rapidly responded to PMA (10 ng/ml), generating almost 10(6) cpm within 20 min and 26.7 nM O-2/10(6) cells/30 min, as detected by CL and reduction of cytochrome c, respectively.	Tetradecanoylphorbol Acetate	36-39	cytochrome c, somatic	Homo sapiens	165-177
6609189-1	1984	TPA alone did not induce the production of IL 2 in human tonsillar lymphocytes but enhanced the PHA-induced IL 2 production by seven-fold.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Homo sapiens	108-112
6609189-2	1984	That the effect of TPA was due to an increase in IL 2 mRNA was demonstrated by examining the amount of IL 2 mRNA translatable in Xenopus laevis oocytes, and by Northern blotting analysis using IL 2 cDNA as a probe.	Tetradecanoylphorbol Acetate	19-22	interleukin 2	Homo sapiens	49-53
6609189-2	1984	That the effect of TPA was due to an increase in IL 2 mRNA was demonstrated by examining the amount of IL 2 mRNA translatable in Xenopus laevis oocytes, and by Northern blotting analysis using IL 2 cDNA as a probe.	Tetradecanoylphorbol Acetate	19-22	interleukin 2	Homo sapiens	103-107
6609189-2	1984	That the effect of TPA was due to an increase in IL 2 mRNA was demonstrated by examining the amount of IL 2 mRNA translatable in Xenopus laevis oocytes, and by Northern blotting analysis using IL 2 cDNA as a probe.	Tetradecanoylphorbol Acetate	19-22	interleukin 2	Homo sapiens	103-107
6609189-3	1984	In these ways, it was shown that TPA alone did not induce any significant IL 2 mRNA synthesis, but when added together with PHA it increased the level of IL 2 mRNA by at least 10-fold, as compared with that induced by PHA alone.	Tetradecanoylphorbol Acetate	33-36	interleukin 2	Homo sapiens	154-158
6328486-1	1984	Treatment of human K562 cells with 4 beta-phorbol 12-myristate 13-acetate (PMA) resulted in an approximately 50% reduction in cell surface transferrin receptors within 30-45 min as judged by binding of both ligand and anti-receptor antibody.	Tetradecanoylphorbol Acetate	35-73	transferrin	Homo sapiens	139-150
6328486-1	1984	Treatment of human K562 cells with 4 beta-phorbol 12-myristate 13-acetate (PMA) resulted in an approximately 50% reduction in cell surface transferrin receptors within 30-45 min as judged by binding of both ligand and anti-receptor antibody.	Tetradecanoylphorbol Acetate	75-78	transferrin	Homo sapiens	139-150
6328486-4	1984	The kinetic parameters for the binding, internalization, intracellular residency, and recycling of 125I-labeled transferrin were unchanged by PMA treatment, as were the rate and extent of internalization of anti-receptor antibody.	Tetradecanoylphorbol Acetate	142-145	transferrin	Homo sapiens	112-123
6423641-1	1984	Immune interferon (IFN-gamma), endogenously labeled with [35S]methionine, was produced in human peripheral blood lymphocyte cultures stimulated with 12-O-tetradecanoylphorbol-13-acetate and phytohemagglutinin.	Tetradecanoylphorbol Acetate	149-185	interferon gamma	Homo sapiens	0-28
6704428-10	1984	Fibronectin synthesis or secretion was not affected by ethylnitrosourea-induced transformation, but the production of fibronectin was enhanced in the transformed cultures treated with TPA.	Tetradecanoylphorbol Acetate	184-187	fibronectin 1	Homo sapiens	118-129
6319411-2	1984	Neutrophils, activated by either opsonized zymosan particles or the soluble stimulus phorbol myristate acetate, released O-2, which subsequently entered the ghosts and reduced (Fe3+)cytochrome c.	Tetradecanoylphorbol Acetate	85-110	cytochrome c, somatic	Homo sapiens	182-194
6321473-5	1984	These are identical with three new phosphopeptides present in the EGF receptor isolated from A431 cells treated with either of the tumor promoters 12-O-tetradecanoylphorbol 13-acetate or teleocidin.	Tetradecanoylphorbol Acetate	147-183	epidermal growth factor receptor	Homo sapiens	66-78
6606672-7	1984	Another marker of activated lymphocytes, LB-1, was also often induced or increased in its expression after exposure of the cells to TPA.	Tetradecanoylphorbol Acetate	132-135	cytoskeleton associated protein 2	Homo sapiens	41-45
6324308-1	1984	Stimulation of human neutrophils with phorbol myristate acetate results in a metabolic burst, which can be measured as an enhanced cytochrome c reduction or NBT reduction.	Tetradecanoylphorbol Acetate	38-63	cytochrome c, somatic	Homo sapiens	131-143
6425426-2	1984	Mouse gamma interferon (IFN-gamma) was produced from a cloned T-cell lymphoma, L12-R4, stimulated with phorbol myristic acetate (PMA) at a concentration of 2 X 10(-7) M/ml.	Tetradecanoylphorbol Acetate	129-132	interferon gamma	Mus musculus	6-33
6363246-0	1984	Increased sensitivity of mouse mammary gland for hormones and tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate in tissues containing the Mtv-2 gene.	Tetradecanoylphorbol Acetate	77-114	mammary tumor virus locus 2	Mus musculus	141-146
6363246-3	1984	A significantly lower response towards prolactin and TPA was observed in mammary explants derived from GR/Mtv-2-mice.	Tetradecanoylphorbol Acetate	53-56	mammary tumor virus locus 2	Mus musculus	106-111
6232432-6	1984	Immunoprecipitation, after ectolabeling of the cells with the C17 antibody and SDS-polyacrylamide gel electrophoresis, proved that TPA-induced K562 expressed both GP IIIa and GP IIb.	Tetradecanoylphorbol Acetate	131-134	integrin subunit beta 3	Homo sapiens	163-170
6232432-7	1984	However, the monoclonal antibody C15 directed against another epitope of platelet GP IIIa reacted only partially, or not at all, indicating that GP IIIa expressed on TPA-induced K562 differs structurally from that on normal platelets.	Tetradecanoylphorbol Acetate	166-169	integrin subunit beta 3	Homo sapiens	145-152
6088899-2	1984	Exposure of these cells to 12-0-tetradecanoyl phorbol-13-acetate (TPA) at 37 degrees C results in a 40% reduction of the specific binding of 125I-transferrin, which is apparent within 15 min.	Tetradecanoylphorbol Acetate	66-69	transferrin	Homo sapiens	146-157
6088899-5	1984	TPA reduces the number of transferrin receptors, and does not alter the degradation or the internalization of transferrin.	Tetradecanoylphorbol Acetate	0-3	transferrin	Homo sapiens	26-37
6317217-3	1983	Binding competition studies indicate that TPA can compete with dexamethasone in binding to the cellular glucocorticoid receptor.	Tetradecanoylphorbol Acetate	42-45	nuclear receptor subfamily 3 group C member 1	Homo sapiens	104-127
6099864-8	1984	Conventional IFN-gamma inducers, concanavalin A and 12-O-tetradecanoyl-phorbol-13-acetate, further enhanced the production of IFN in this cell line.	Tetradecanoylphorbol Acetate	52-89	interferon gamma	Homo sapiens	13-22
6099864-8	1984	Conventional IFN-gamma inducers, concanavalin A and 12-O-tetradecanoyl-phorbol-13-acetate, further enhanced the production of IFN in this cell line.	Tetradecanoylphorbol Acetate	52-89	interferon alpha 1	Homo sapiens	13-16
6607173-4	1983	In the cultures containing a sufficient amount of exogenous T cell growth factor (TCGF), the enhancement of T lymphocyte colony formation by TPA was not observed.	Tetradecanoylphorbol Acetate	141-144	interleukin 2	Homo sapiens	60-80
6689054-3	1983	It was therefore of interest to ascertain whether the 20,000-MW peptide phosphorylated in platelets was the light chain of myosin and whether TPA-induced phosphorylation of the 20,000-MW peptide could be differentiated from thrombin-induced phosphorylation.	Tetradecanoylphorbol Acetate	142-145	coagulation factor II, thrombin	Homo sapiens	224-232
6607173-4	1983	In the cultures containing a sufficient amount of exogenous T cell growth factor (TCGF), the enhancement of T lymphocyte colony formation by TPA was not observed.	Tetradecanoylphorbol Acetate	141-144	interleukin 2	Homo sapiens	82-86
6607173-5	1983	TPA enhanced TCGF production by peripheral lymphocytes stimulated with PHA.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Homo sapiens	13-17
6607173-7	1983	These findings suggest that TPA enhanced T lymphocyte colony formation by stimulating endogenous TCGF production.	Tetradecanoylphorbol Acetate	28-31	interleukin 2	Homo sapiens	97-101
6413878-3	1983	Phospholipase A2 and phorbol myristate acetate, substances that increase intracellular concentrations of arachidonic acid, markedly stimulated prolactin release by dispersed pituitary cells and by anterior pituitary glands incubated in vitro.	Tetradecanoylphorbol Acetate	21-46	prolactin	Homo sapiens	143-152
6312447-3	1983	Insulin also enhanced the phosphorylation of the beta subunit of the insulin receptor, and its effects appeared to be additive to those of TPA.	Tetradecanoylphorbol Acetate	139-142	insulin	Homo sapiens	69-76
6884492-0	1983	Possible role of calmodulin in stimulation of hexose transport by 12-O-tetradecanoylphorbol-13-acetate, a tumor promoter.	Tetradecanoylphorbol Acetate	66-102	calmodulin 1	Homo sapiens	17-27
6884492-2	1983	Three different kinds of calmodulin antagonists inhibited the TPA-stimulated 2DG transport, the mechanism of which was examined in kinetic analysis.	Tetradecanoylphorbol Acetate	62-65	calmodulin 1	Homo sapiens	25-35
6884492-3	1983	These results indicate that the expression of the effect of TPA may depend on Ca2+-calmodulin system.	Tetradecanoylphorbol Acetate	60-63	calmodulin 1	Homo sapiens	83-93
6621591-5	1983	It has been suggested [9] that the failure of some laboratories to detect increases in sister-chromatid exchanges after treatment with the tumor promoter phorbol-myristate-acetate (PMA) may be due to high concentrations of the free-radical-scavenging enzyme superoxide dismutase (SOD) in the sera used and that heat inactivation of the sera may be responsible for these differences.	Tetradecanoylphorbol Acetate	154-179	superoxide dismutase 1	Homo sapiens	258-278
6621591-5	1983	It has been suggested [9] that the failure of some laboratories to detect increases in sister-chromatid exchanges after treatment with the tumor promoter phorbol-myristate-acetate (PMA) may be due to high concentrations of the free-radical-scavenging enzyme superoxide dismutase (SOD) in the sera used and that heat inactivation of the sera may be responsible for these differences.	Tetradecanoylphorbol Acetate	154-179	superoxide dismutase 1	Homo sapiens	280-283
6354733-0	1983	TPA induces simultaneous alterations in the synthesis and organization of vimentin.	Tetradecanoylphorbol Acetate	0-3	vimentin	Gallus gallus	74-82
6354733-1	1983	We have found an increased rate of vimentin synthesis in TPA-treated chicken embryonic fibroblasts, as shown by two-dimensional electrophoretic separation of newly synthesized polypeptides.	Tetradecanoylphorbol Acetate	57-60	vimentin	Gallus gallus	35-43
6354733-3	1983	Treatment with TPA also altered the organization of the vimentin-containing intermediate filaments, as revealed by immunofluorescence.	Tetradecanoylphorbol Acetate	15-18	vimentin	Gallus gallus	56-64
6354733-4	1983	Treatments which inhibited the TPA-induced rearrangements of vimentin filaments did not prevent the increase in the rate of vimentin synthesis, indicating that gross alterations in cytoskeletal organization were not the immediate cause of the altered vimentin synthesis.	Tetradecanoylphorbol Acetate	31-34	vimentin	Gallus gallus	61-69
6354733-6	1983	TPA as a positive modulator of vimentin synthesis may serve as a useful probe for an eventual understanding of the dynamics of the mechanisms that control the assembly and organization of vimentin filaments.	Tetradecanoylphorbol Acetate	0-3	vimentin	Gallus gallus	31-39
6354733-6	1983	TPA as a positive modulator of vimentin synthesis may serve as a useful probe for an eventual understanding of the dynamics of the mechanisms that control the assembly and organization of vimentin filaments.	Tetradecanoylphorbol Acetate	0-3	vimentin	Gallus gallus	188-196
6311062-3	1983	A similar loss of binding to and inactivation of human neutrophil elastase was observed on exposure of alpha 1-protease inhibitor to human neutrophils in the presence of a halide and the neutrophil-activating agent, phorbol myristate acetate.	Tetradecanoylphorbol Acetate	216-241	serpin family A member 1	Homo sapiens	103-129
6135503-3	1983	Five other protease inhibitors, antipain, leupeptin, pepstatin, aprotinin, and soybean trypsin inhibitor, also suppressed TPA induction of transglutaminase activity.	Tetradecanoylphorbol Acetate	122-125	kunitz trypsin protease inhibitor	Glycine max	87-104
6861149-0	1983	Glucocorticoid receptor levels in mouse skin after repetitive applications of 12-O-tetradecanoylphorbol-13-acetate and mezerein.	Tetradecanoylphorbol Acetate	78-114	nuclear receptor subfamily 3, group C, member 1	Mus musculus	0-23
6194706-4	1983	A PLA2 activator, 12-0-tetradecanoylphorbol-13-acetate (TPA) caused basophil histamine release with a dose-dependent fashion.	Tetradecanoylphorbol Acetate	56-59	phospholipase A2 group IB	Homo sapiens	2-6
6861149-4	1983	The glucocorticoid receptor level was markedly reduced and remained low for at least 72 hr after repetitive applications of TPA.	Tetradecanoylphorbol Acetate	124-127	nuclear receptor subfamily 3, group C, member 1	Mus musculus	4-27
6861149-8	1983	If four applications of mezerein were preceded by four applications of TPA, then the glucocorticoid receptor level was similar to that after TPA alone.	Tetradecanoylphorbol Acetate	71-74	nuclear receptor subfamily 3, group C, member 1	Mus musculus	85-108
6306584-1	1983	A recombinant plasmid containing human interleukin 2 (IL2) cDNA was identified in a cDNA library constructed from mRNA derived from PHA-TPA induced splenocytes.	Tetradecanoylphorbol Acetate	136-139	interleukin 2	Homo sapiens	39-52
6308055-2	1983	Stimulation of neutrophil oxygen (O2) metabolism with phorbol myristate acetate or opsonized zymosan resulted in production of hydrogen peroxide (H2O2), myeloperoxidase-catalyzed oxidation of chloride (C1-) to hypochlorous acid (HOC1), and the reaction of HOC1 with the added compounds to yield nitrogen-chlorine (N-C1) derivatives.	Tetradecanoylphorbol Acetate	54-79	myeloperoxidase	Homo sapiens	153-168
6602780-7	1983	However, they could be induced to produce IL-2 activity by stimulation with TPA or TPA plus PHA.	Tetradecanoylphorbol Acetate	76-79	interleukin 2	Homo sapiens	42-46
6602780-7	1983	However, they could be induced to produce IL-2 activity by stimulation with TPA or TPA plus PHA.	Tetradecanoylphorbol Acetate	83-86	interleukin 2	Homo sapiens	42-46
6602780-8	1983	Irradiation of the proliferating T-CLL cells prior to incubation with TPA or TPA plus PHA resulted in a 9-fold increase in IL-2 activity, suggesting that the proliferating T-CLL cells were able to consume the IL-2 they produced.	Tetradecanoylphorbol Acetate	70-73	interleukin 2	Homo sapiens	123-127
6602780-8	1983	Irradiation of the proliferating T-CLL cells prior to incubation with TPA or TPA plus PHA resulted in a 9-fold increase in IL-2 activity, suggesting that the proliferating T-CLL cells were able to consume the IL-2 they produced.	Tetradecanoylphorbol Acetate	70-73	interleukin 2	Homo sapiens	209-213
6602780-8	1983	Irradiation of the proliferating T-CLL cells prior to incubation with TPA or TPA plus PHA resulted in a 9-fold increase in IL-2 activity, suggesting that the proliferating T-CLL cells were able to consume the IL-2 they produced.	Tetradecanoylphorbol Acetate	77-80	interleukin 2	Homo sapiens	123-127
6602780-8	1983	Irradiation of the proliferating T-CLL cells prior to incubation with TPA or TPA plus PHA resulted in a 9-fold increase in IL-2 activity, suggesting that the proliferating T-CLL cells were able to consume the IL-2 they produced.	Tetradecanoylphorbol Acetate	77-80	interleukin 2	Homo sapiens	209-213
6409425-1	1983	Previous studies showed that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and several structurally related tumor-promoting compounds stimulate lymphocytes to produce immune interferon (IFN-gamma) and interleukin 2 (IL-2).	Tetradecanoylphorbol Acetate	63-99	interferon gamma	Homo sapiens	217-226
6409425-1	1983	Previous studies showed that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and several structurally related tumor-promoting compounds stimulate lymphocytes to produce immune interferon (IFN-gamma) and interleukin 2 (IL-2).	Tetradecanoylphorbol Acetate	63-99	interleukin 2	Homo sapiens	232-245
6409425-1	1983	Previous studies showed that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and several structurally related tumor-promoting compounds stimulate lymphocytes to produce immune interferon (IFN-gamma) and interleukin 2 (IL-2).	Tetradecanoylphorbol Acetate	63-99	interleukin 2	Homo sapiens	247-251
6409425-1	1983	Previous studies showed that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and several structurally related tumor-promoting compounds stimulate lymphocytes to produce immune interferon (IFN-gamma) and interleukin 2 (IL-2).	Tetradecanoylphorbol Acetate	101-104	interferon gamma	Homo sapiens	217-226
6409425-1	1983	Previous studies showed that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and several structurally related tumor-promoting compounds stimulate lymphocytes to produce immune interferon (IFN-gamma) and interleukin 2 (IL-2).	Tetradecanoylphorbol Acetate	101-104	interleukin 2	Homo sapiens	232-245
6409425-1	1983	Previous studies showed that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and several structurally related tumor-promoting compounds stimulate lymphocytes to produce immune interferon (IFN-gamma) and interleukin 2 (IL-2).	Tetradecanoylphorbol Acetate	101-104	interleukin 2	Homo sapiens	247-251
6306584-1	1983	A recombinant plasmid containing human interleukin 2 (IL2) cDNA was identified in a cDNA library constructed from mRNA derived from PHA-TPA induced splenocytes.	Tetradecanoylphorbol Acetate	136-139	interleukin 2	Homo sapiens	54-57
6602179-9	1983	When incubated simultaneously with TPA and T cell growth factor (IL 2), all lines responded with greater DNA synthesis than when incubated with IL 2 or TPA alone, thus demonstrating a synergistic action between TPA and IL 2.	Tetradecanoylphorbol Acetate	152-155	interleukin 2	Homo sapiens	43-63
6408170-12	1983	Our results indicate that TPA mimics IL 1 in the induction of differentiation of the ST to a stage in which subpopulations of these cells are able to produce IL 2 and to respond to PHA.	Tetradecanoylphorbol Acetate	26-29	lamin B receptor	Homo sapiens	181-184
6863281-4	1983	The irreversible chymotrypsin-like protease inhibitor TPCK (tosyl-L-phenylalanyl chloromethyl ketone) inhibited membrane potential changes in rat neutrophils in response to phorbol myristate acetate, N-formylmethionylleucylphenylalanine and the calcium ionophore A23187 in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	173-198	mast cell protease 1-like 1	Rattus norvegicus	17-43
6602179-9	1983	When incubated simultaneously with TPA and T cell growth factor (IL 2), all lines responded with greater DNA synthesis than when incubated with IL 2 or TPA alone, thus demonstrating a synergistic action between TPA and IL 2.	Tetradecanoylphorbol Acetate	152-155	interleukin 2	Homo sapiens	65-69
6602179-9	1983	When incubated simultaneously with TPA and T cell growth factor (IL 2), all lines responded with greater DNA synthesis than when incubated with IL 2 or TPA alone, thus demonstrating a synergistic action between TPA and IL 2.	Tetradecanoylphorbol Acetate	152-155	interleukin 2	Homo sapiens	43-63
6602179-9	1983	When incubated simultaneously with TPA and T cell growth factor (IL 2), all lines responded with greater DNA synthesis than when incubated with IL 2 or TPA alone, thus demonstrating a synergistic action between TPA and IL 2.	Tetradecanoylphorbol Acetate	152-155	interleukin 2	Homo sapiens	65-69
6682377-0	1983	Effects of 12-O-tetradecanoylphorbol 13-acetate on the production of mRNAs for human tissue-type plasminogen activator.	Tetradecanoylphorbol Acetate	11-47	plasminogen activator, tissue type	Homo sapiens	85-118
6305527-5	1983	TPA was shown to reduce the SOD levels in these cells.	Tetradecanoylphorbol Acetate	0-3	superoxide dismutase 1	Homo sapiens	28-31
6833404-8	1983	Although an elevation of ornithine decarboxylase levels occurred in 3T3-TNR-2 cells treated with TPA, the maximal specific activity in the variant was less than the unstimulated value for 3T3 cells.	Tetradecanoylphorbol Acetate	97-100	tenascin R	Mus musculus	72-75
6300862-5	1983	TPA stimulated cell proliferation and inhibited the synthesis of milk proteins casein and alpha-lactalbumin during a 5-day culture.	Tetradecanoylphorbol Acetate	0-3	lactalbumin, alpha	Mus musculus	90-107
6301466-2	1983	DCIP reductase, cytochrome c reductase and a chromophore 450-455 reductase are present in phorbol myristate acetate stimulated neutrophils and absent in resting cells and phorbol myristate acetate stimulated chronic granulomatous disease cells.	Tetradecanoylphorbol Acetate	90-115	cytochrome c, somatic	Homo sapiens	16-28
6301466-2	1983	DCIP reductase, cytochrome c reductase and a chromophore 450-455 reductase are present in phorbol myristate acetate stimulated neutrophils and absent in resting cells and phorbol myristate acetate stimulated chronic granulomatous disease cells.	Tetradecanoylphorbol Acetate	171-196	cytochrome c, somatic	Homo sapiens	16-28
6337966-4	1983	Since human blood monocytes (BM) are characterized by five acid esterase (AcE; EC 3.1.1.6) isoenzymes which are cell-specific in terms of isoelectric points (pI) and antigenicity, attempts were made in the present study to identify identical isoenzyme patterns in non- and TPA-stimulated U-937 cells.	Tetradecanoylphorbol Acetate	273-276	angiotensin I converting enzyme	Homo sapiens	74-77
6337966-8	1983	Antisera raised against AcE of BM immunoprecipitated the two additional isoenzymes of TPA-stimulated U-937.	Tetradecanoylphorbol Acetate	86-89	angiotensin I converting enzyme	Homo sapiens	24-27
6337966-10	1983	(2) TPA-stimulation caricatures transformation of BM into resident tissue macrophages as far as pure morphology and AcE isoenzyme patterns are concerned.	Tetradecanoylphorbol Acetate	4-7	angiotensin I converting enzyme	Homo sapiens	116-119
6300993-5	1983	These data suggest that, under our experimental conditions, the ox erythrocyte killing by phorbol myristate acetate-activated neutrophils mainly depends on myeloperoxidase and hydrogen peroxide.	Tetradecanoylphorbol Acetate	90-115	myeloperoxidase	Homo sapiens	156-171
6188625-11	1983	Furthermore, immunoprecipitation of the culture supernatants from these cells has shown that TPA induces the synthesis and secretion of fibronectin.	Tetradecanoylphorbol Acetate	93-96	fibronectin 1	Homo sapiens	136-147
6294178-10	1983	The ability of FMLP to enhance cytotoxic responses correlated well with its enhancement of PMA-stimulated chemiluminescence under a variety of conditions.	Tetradecanoylphorbol Acetate	91-94	formyl peptide receptor 1	Homo sapiens	15-19
6294178-11	1983	In addition, the ability of PMA-stimulated neutrophils to mediate methane generation from dimethyl sulfoxide and ethylene generation from alpha keto-gamma-methiol-butyric acid (KMB)--assays that quantitate the generation of oxidizing radicals--was increased if the neutrophils were preincubated with FMLP.	Tetradecanoylphorbol Acetate	28-31	formyl peptide receptor 1	Homo sapiens	300-304
6891320-7	1982	It is less prominent at 22 degrees C than at 37 degrees C. It is reversible within 2 h at 37 degrees C. TPA reduces the binding of insulin predominantly by increasing its dissociation rate.	Tetradecanoylphorbol Acetate	104-107	insulin	Homo sapiens	131-138
6417283-2	1983	As previously reported, costimulation by 5 ng/ml of 12-O-tetradecanoylphorbol-13-acetate (TPA) and 5 microgram/ml of phytohemagglutinin (PHA) caused a marked enhancement of IFN-gamma levels compared to the yields obtained with PHA alone.	Tetradecanoylphorbol Acetate	52-88	interferon gamma	Homo sapiens	173-182
6417283-2	1983	As previously reported, costimulation by 5 ng/ml of 12-O-tetradecanoylphorbol-13-acetate (TPA) and 5 microgram/ml of phytohemagglutinin (PHA) caused a marked enhancement of IFN-gamma levels compared to the yields obtained with PHA alone.	Tetradecanoylphorbol Acetate	90-93	interferon gamma	Homo sapiens	173-182
6417283-4	1983	Mezerein (MZN), a compound structurally related to TPA, was found to be similar to TPA in enhancing IFN-gamma and IL-2 levels.	Tetradecanoylphorbol Acetate	83-86	interferon gamma	Homo sapiens	100-109
6417283-4	1983	Mezerein (MZN), a compound structurally related to TPA, was found to be similar to TPA in enhancing IFN-gamma and IL-2 levels.	Tetradecanoylphorbol Acetate	83-86	interleukin 2	Homo sapiens	114-118
6602934-1	1983	Poly(A)-positive mRNA extracted from tonsillar mononuclear cells stimulated with phytohemagglutinin-M and 12-o-tetradecanoyl phorbol 13-acetate was successfully translated into biologically active interleukin 2 (IL-2) in Xenopus laevis oocytes, and secreted into the incubation medium.	Tetradecanoylphorbol Acetate	106-143	interleukin 2	Homo sapiens	197-210
7200397-7	1982	Trifluoperazine and N-(6-aminohexyl)-5-chloronaphthalenesulfonamide, known inhibitors of the calmodulin-dependent processes, also selectively block the TPA-stimulated cap formation, whereas trifluoperazine sulfoxide, a less effective calmodulin antagonist, is relatively inactive.	Tetradecanoylphorbol Acetate	152-155	calmodulin	Bos taurus	93-103
6961843-4	1982	TPA treatment of HL60 cells causes the rapid disappearance of the transferrin receptor from the cell surface.	Tetradecanoylphorbol Acetate	0-3	transferrin	Homo sapiens	66-77
7139611-4	1982	The potent promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) reversibly increased the proportion of SH-SY5Y cells with neurites and the average length of neurites; the effects of the combination of TPA and NGF were greater than that of either compound alone.	Tetradecanoylphorbol Acetate	20-56	nerve growth factor	Homo sapiens	208-211
7139611-4	1982	The potent promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) reversibly increased the proportion of SH-SY5Y cells with neurites and the average length of neurites; the effects of the combination of TPA and NGF were greater than that of either compound alone.	Tetradecanoylphorbol Acetate	58-61	nerve growth factor	Homo sapiens	208-211
7139611-11	1982	TPA also enhanced neurite outgrowth in another NGF responsive line, LA-N-5, but not in two unresponsive lines, CHP-100 and CHP-134.	Tetradecanoylphorbol Acetate	0-3	nerve growth factor	Homo sapiens	47-50
6980230-10	1982	Tumor cells from eight patients with Ia + CALLA + B1-c mu- ALL could be induced in vitro with TPA to express both B1 and c mu.	Tetradecanoylphorbol Acetate	94-97	membrane metalloendopeptidase	Homo sapiens	42-47
6980230-10	1982	Tumor cells from eight patients with Ia + CALLA + B1-c mu- ALL could be induced in vitro with TPA to express both B1 and c mu.	Tetradecanoylphorbol Acetate	94-97	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	114-125
6819174-0	1982	Inhibition of 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion by nordihydroguaiaretic acid, a lipoxygenase inhibitor, and p-bromophenacyl bromide, a phospholipase A2 inhibitor.	Tetradecanoylphorbol Acetate	14-51	phospholipase A2 group IB	Homo sapiens	163-179
6751097-2	1982	TPA markedly inhibits insulin binding to cultured human lymphocytes and macrophages but has a minimal effect on human fibroblasts.	Tetradecanoylphorbol Acetate	0-3	insulin	Homo sapiens	22-29
6751097-5	1982	Insulin binding is decreased by TPA whether the phorbol ester is added before, after, or simultaneously with 125I-insulin to the cell suspension.	Tetradecanoylphorbol Acetate	32-35	insulin	Homo sapiens	0-7
6751097-9	1982	The specific mechanism of TPA action that affects the receptor of these two potent growth factors (i.e., insulin and epidermal growth factor), however, is unknown.	Tetradecanoylphorbol Acetate	26-29	insulin	Homo sapiens	105-112
6177764-2	1982	Lymphocyte proliferation was significantly enhanced in cultures with PMA at concentrations greater than or equal to 12.5 ng/ml, and interferon-gamma production was synergistically increased in cultures with PMA at concentrations greater than or equal to 5 ng/ml.	Tetradecanoylphorbol Acetate	207-210	interferon gamma	Homo sapiens	132-148
7200397-7	1982	Trifluoperazine and N-(6-aminohexyl)-5-chloronaphthalenesulfonamide, known inhibitors of the calmodulin-dependent processes, also selectively block the TPA-stimulated cap formation, whereas trifluoperazine sulfoxide, a less effective calmodulin antagonist, is relatively inactive.	Tetradecanoylphorbol Acetate	152-155	calmodulin	Bos taurus	234-244
7200397-8	1982	These data suggest that the stimulation of capping by TPA involves the activation of a calmodulin-dependent process which may also be regulated by the function of an esterase.	Tetradecanoylphorbol Acetate	54-57	calmodulin	Bos taurus	87-97
6980126-6	1982	Stimulation of the IL2-producing JMN or JHAN variants with PHA, the phorbol diester 12-0-tetradecanoyl-phorbol-13-acetate (TPA), or both PHA and TPA together, resulted in an apparent increase of IL2 activity in the culture supernatant when assayed by a short-term tritiated thymidine incorporation test.	Tetradecanoylphorbol Acetate	123-126	interleukin 2	Homo sapiens	19-22
6980126-6	1982	Stimulation of the IL2-producing JMN or JHAN variants with PHA, the phorbol diester 12-0-tetradecanoyl-phorbol-13-acetate (TPA), or both PHA and TPA together, resulted in an apparent increase of IL2 activity in the culture supernatant when assayed by a short-term tritiated thymidine incorporation test.	Tetradecanoylphorbol Acetate	145-148	interleukin 2	Homo sapiens	19-22
6980126-10	1982	Addition of TPA, but not of PHA, to lectin and TPA-free JMN IL2 resulted in a decreased ability of such supernatants to support clonal T cell growth, suggesting that TPA had a growth-inhibiting effect.	Tetradecanoylphorbol Acetate	12-15	interleukin 2	Homo sapiens	60-63
6980126-10	1982	Addition of TPA, but not of PHA, to lectin and TPA-free JMN IL2 resulted in a decreased ability of such supernatants to support clonal T cell growth, suggesting that TPA had a growth-inhibiting effect.	Tetradecanoylphorbol Acetate	47-50	interleukin 2	Homo sapiens	60-63
6980126-10	1982	Addition of TPA, but not of PHA, to lectin and TPA-free JMN IL2 resulted in a decreased ability of such supernatants to support clonal T cell growth, suggesting that TPA had a growth-inhibiting effect.	Tetradecanoylphorbol Acetate	47-50	interleukin 2	Homo sapiens	60-63
7076851-12	1982	Suppression of NK by TPA was inhibited by catalase.	Tetradecanoylphorbol Acetate	21-24	catalase	Homo sapiens	42-50
6980181-0	1982	The effect of phorbol-myristate acetate and concanavalin A on the growth of interleukin-2-dependent T-cell lines.	Tetradecanoylphorbol Acetate	14-39	interleukin 2	Homo sapiens	76-89
6949641-2	1982	In an original cell line, THP-1-O, cultured again from -80 degrees cryopreservation, more than 80% of the cells adhered to the glass substrate with marked morphological change within 3 hr of TPA treatment.	Tetradecanoylphorbol Acetate	191-194	GLI family zinc finger 2	Homo sapiens	26-31
6949641-5	1982	On the other hand, in THP-1-R cells cultured continuously without cryopreservation for 26 months, approximately 80% of the cells adhered to the substrate 48 hr after TPA treatment.	Tetradecanoylphorbol Acetate	166-169	GLI family zinc finger 2	Homo sapiens	22-27
6949641-6	1982	Round and ovoid shapes were kept in THP-1-R cells treated with TPA.	Tetradecanoylphorbol Acetate	63-66	GLI family zinc finger 2	Homo sapiens	36-41
6949641-8	1982	Sixty to 70% of the TPA-treated THP-1-O and THP-1-R cells were able to phagocytize yeasts and immunoglobulin G-coated sheep erythrocytes.	Tetradecanoylphorbol Acetate	20-23	GLI family zinc finger 2	Homo sapiens	32-37
6949641-12	1982	When exposed to latex beads and TPA, increased 14CO2 production from [1-14C]glucose in THP-1-O cells was observed.	Tetradecanoylphorbol Acetate	32-35	GLI family zinc finger 2	Homo sapiens	87-92
6327273-5	1982	Treatment of P3HR-1 cells with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or hydrocortisone (HC), which induce similar changes in cell cycle distribution as does IFN, did not induce comparable changes in the rates of protein synthesis.	Tetradecanoylphorbol Acetate	70-73	interferon alpha 1	Homo sapiens	163-166
6977565-2	1982	Human interleukin 2 (IL 2) was produced under serum-free conditions by stimulating mononuclear cells with concanavalin A (Con A) in the presence of phorbol myristate acetate (PMA) and hydroxyurea.	Tetradecanoylphorbol Acetate	148-173	interleukin 2	Homo sapiens	6-19
6977565-2	1982	Human interleukin 2 (IL 2) was produced under serum-free conditions by stimulating mononuclear cells with concanavalin A (Con A) in the presence of phorbol myristate acetate (PMA) and hydroxyurea.	Tetradecanoylphorbol Acetate	148-173	interleukin 2	Homo sapiens	21-25
6977565-2	1982	Human interleukin 2 (IL 2) was produced under serum-free conditions by stimulating mononuclear cells with concanavalin A (Con A) in the presence of phorbol myristate acetate (PMA) and hydroxyurea.	Tetradecanoylphorbol Acetate	175-178	interleukin 2	Homo sapiens	6-19
6977565-2	1982	Human interleukin 2 (IL 2) was produced under serum-free conditions by stimulating mononuclear cells with concanavalin A (Con A) in the presence of phorbol myristate acetate (PMA) and hydroxyurea.	Tetradecanoylphorbol Acetate	175-178	interleukin 2	Homo sapiens	21-25
7059675-4	1982	Binding of both L5.1 and transferrin to the surface of K562(S) cells is inhibited by treatment with 12--O-tetradecanoyl-phorbol-13-acetate, and the extent and time course of inhibition is similar in both cases.	Tetradecanoylphorbol Acetate	100-138	transferrin	Homo sapiens	25-36
7035564-4	1982	TPA induced REH cells to express the leukemia-associated antigen, p24 (detected with monoclonal antibody BA-2; p24/BA-2) by 8 hr of culture, with induction complete by 24 hr.	Tetradecanoylphorbol Acetate	0-3	transmembrane p24 trafficking protein 2	Homo sapiens	37-69
7035564-4	1982	TPA induced REH cells to express the leukemia-associated antigen, p24 (detected with monoclonal antibody BA-2; p24/BA-2) by 8 hr of culture, with induction complete by 24 hr.	Tetradecanoylphorbol Acetate	0-3	transmembrane p24 trafficking protein 2	Homo sapiens	66-69
6177002-1	1982	Interferon (IFN)-gamma was produced in cultures of human leukocytes by combined stimulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) and phytohemagglutinin (PHA).	Tetradecanoylphorbol Acetate	97-133	interferon gamma	Homo sapiens	0-22
6177002-1	1982	Interferon (IFN)-gamma was produced in cultures of human leukocytes by combined stimulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) and phytohemagglutinin (PHA).	Tetradecanoylphorbol Acetate	135-138	interferon gamma	Homo sapiens	0-22
7066921-4	1982	ACR cells when exposed to TPA alone appear to grow in the anterior chamber of the eye of a nude mouse.	Tetradecanoylphorbol Acetate	26-29	acrosin prepropeptide	Mus musculus	0-3
7067943-4	1982	The data presented indicate that inhibition of protein synthesis by the use of cycloheximide prevents the appearance of TPA induced inhibition of the expression of differentiative products, such as creatine phosphokinase (CPK) activity and acetylcholine receptors (AChR).	Tetradecanoylphorbol Acetate	120-123	cholinergic receptor nicotinic delta subunit	Gallus gallus	240-263
7067943-4	1982	The data presented indicate that inhibition of protein synthesis by the use of cycloheximide prevents the appearance of TPA induced inhibition of the expression of differentiative products, such as creatine phosphokinase (CPK) activity and acetylcholine receptors (AChR).	Tetradecanoylphorbol Acetate	120-123	cholinergic receptor nicotinic delta subunit	Gallus gallus	265-269
7067943-5	1982	Following removal of cycloheximide and reinitiation of normal protein synthesis, the TPA induced inhibitory effect on CPK and AChR appears after a delay of about the same length as the time lag of TPA action.	Tetradecanoylphorbol Acetate	85-88	cholinergic receptor nicotinic delta subunit	Gallus gallus	126-130
6267057-1	1981	Activation of normal or myeloperoxidase-deficient human granulocytes by phorbol myristate acetate resulted in an initial membrane depolarization as indicated by an increase in fluorescence of the lipophilic cation probe of membrane potential, 3,3"-dipropylthiodicarbocyanine.	Tetradecanoylphorbol Acetate	72-97	myeloperoxidase	Homo sapiens	24-39
6281283-1	1982	12-)-Tetradecanoylphorbol-13-acetate (TPA), the prototype polyfunctional diterpene ester tumor promoter of two-step carcinogenesis in mouse skin, induced differentiation of human promyelocytic leukemia cells (HL-60) in culture.	Tetradecanoylphorbol Acetate	0-36	promotion susceptibility QTL 1	Mus musculus	38-41
6188944-8	1982	Spontaneously produced IFN was detected more easily in cells transformed by EBV alone than in those transformed by EBV and a tumor promoter, TPA.	Tetradecanoylphorbol Acetate	141-144	interferon alpha 1	Homo sapiens	23-26
7053244-4	1981	Neutrophil phagocytosis of 51Cr-labeled opsonized sheep erythrocytes (51Cr-EAC) and superoxide anion (O2-) production in response to FMLP or phorbol myristate acetate (PMA) stimulation were not affected by pretreating cells with NCD3.	Tetradecanoylphorbol Acetate	168-171	formyl peptide receptor 1	Homo sapiens	133-137
6975761-5	1981	TPA induced different subsets of differentiation-associated protein changes in the different clones and the degree of response to TPA was not necessarily related to the degree of response to MGI.	Tetradecanoylphorbol Acetate	0-3	pleckstrin homology domain containing, family M, member 3	Mus musculus	33-67
6975761-7	1981	Combined treatment with TPA and MGI resulted in an enhancement of protein changes induced by MGI or TPA alone and induced differentiation-associated protein changes not induced by either compound separately in differentiation-defective clones.	Tetradecanoylphorbol Acetate	24-27	pleckstrin homology domain containing, family M, member 3	Mus musculus	122-156
7116561-6	1982	Ornithine decarboxylase (ODC) activity has been evaluated in the epidermis of guniea pig ear after topical application of 20 nmol of TPA.	Tetradecanoylphorbol Acetate	133-136	ornithine decarboxylase 1	Sus scrofa	0-23
7116561-6	1982	Ornithine decarboxylase (ODC) activity has been evaluated in the epidermis of guniea pig ear after topical application of 20 nmol of TPA.	Tetradecanoylphorbol Acetate	133-136	ornithine decarboxylase 1	Sus scrofa	25-28
6170583-1	1981	The diterpene ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and several structurally related compounds were tested for their ability to stimulate interferon (IFN) production in primary cultures of human leukocytes.	Tetradecanoylphorbol Acetate	20-56	interferon alpha 1	Homo sapiens	139-165
6170583-1	1981	The diterpene ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and several structurally related compounds were tested for their ability to stimulate interferon (IFN) production in primary cultures of human leukocytes.	Tetradecanoylphorbol Acetate	58-61	interferon alpha 1	Homo sapiens	139-165
6170583-2	1981	In cultures of Ficoll-Hypaque-purified mononuclear cells, TPA treatment alone induced only low levels of IFN, but TPA pretreatment of cells caused significant enhancement of IFN yields produced with phytohemagglutinin or several other T cell mitogens.	Tetradecanoylphorbol Acetate	58-61	interferon alpha 1	Homo sapiens	105-108
6170583-2	1981	In cultures of Ficoll-Hypaque-purified mononuclear cells, TPA treatment alone induced only low levels of IFN, but TPA pretreatment of cells caused significant enhancement of IFN yields produced with phytohemagglutinin or several other T cell mitogens.	Tetradecanoylphorbol Acetate	114-117	interferon alpha 1	Homo sapiens	174-177
6170583-3	1981	In cultures of unprocessed cells derived from plateletpheresis residues or buffy coats, TPA treatment alone induced high levels of IFN and costimulation with TPA and phytohemagglutinin produced some further enhancement of IFN production.	Tetradecanoylphorbol Acetate	88-91	interferon alpha 1	Homo sapiens	131-134
6170583-3	1981	In cultures of unprocessed cells derived from plateletpheresis residues or buffy coats, TPA treatment alone induced high levels of IFN and costimulation with TPA and phytohemagglutinin produced some further enhancement of IFN production.	Tetradecanoylphorbol Acetate	88-91	interferon alpha 1	Homo sapiens	222-225
6170583-4	1981	Phorbol 12,13-dibutyrate was comparable to TPA in its ability to enhance phytohemagglutinin-induced IFN production.	Tetradecanoylphorbol Acetate	43-46	interferon alpha 1	Homo sapiens	100-103
6170583-6	1981	Mezerein, a structurally related diterpene ester, was at least as active as TPA in stimulating IFN production in either Ficoll-Hypaque-purified or unprocessed cells.	Tetradecanoylphorbol Acetate	76-79	interferon alpha 1	Homo sapiens	95-98
6170583-7	1981	IFN produced after stimulation with TPA or mezerein, singly or in combination with phytohemagglutinin, had several properties characteristic of IFN-gamma, e.g., it was largely inactivated by dialysis at pH 2, or after exposure to sodium dodecyl sulfate, whereas it was not neutralized by antibody to IFN-alpha and IFN-beta.	Tetradecanoylphorbol Acetate	36-39	interferon alpha 1	Homo sapiens	0-3
6170583-7	1981	IFN produced after stimulation with TPA or mezerein, singly or in combination with phytohemagglutinin, had several properties characteristic of IFN-gamma, e.g., it was largely inactivated by dialysis at pH 2, or after exposure to sodium dodecyl sulfate, whereas it was not neutralized by antibody to IFN-alpha and IFN-beta.	Tetradecanoylphorbol Acetate	36-39	interferon gamma	Homo sapiens	144-153
6170583-7	1981	IFN produced after stimulation with TPA or mezerein, singly or in combination with phytohemagglutinin, had several properties characteristic of IFN-gamma, e.g., it was largely inactivated by dialysis at pH 2, or after exposure to sodium dodecyl sulfate, whereas it was not neutralized by antibody to IFN-alpha and IFN-beta.	Tetradecanoylphorbol Acetate	36-39	interferon alpha 1	Homo sapiens	300-309
7237415-6	1981	Soybean trypsin inhibitor suppressed only the promotional effects of 12-O-tetradecanoylphorbol-13-acetate on transformation.	Tetradecanoylphorbol Acetate	69-105	kunitz trypsin protease inhibitor	Glycine max	8-25
6267131-2	1981	A 48-hr incubation of murine thioglycollate-elicited macrophages with LPS (0.1 micrograms/ml) resulted in an enhanced ability of these cells to produce oxygen radicals when challenged with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	189-214	toll-like receptor 4	Mus musculus	70-73
6267131-2	1981	A 48-hr incubation of murine thioglycollate-elicited macrophages with LPS (0.1 micrograms/ml) resulted in an enhanced ability of these cells to produce oxygen radicals when challenged with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	216-219	toll-like receptor 4	Mus musculus	70-73
6263380-1	1981	Human neutrophils exposed to chemotactic concentrations of zymosan-activated serum (ZAS) and a formylated chemotactic peptide (FMLP, 10(-7)--10(-9) M) were markedly enhanced in their ability to generate superoxide (O2-) upon stimulation with either sodium fluoride or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	268-293	formyl peptide receptor 1	Homo sapiens	127-131
6263380-1	1981	Human neutrophils exposed to chemotactic concentrations of zymosan-activated serum (ZAS) and a formylated chemotactic peptide (FMLP, 10(-7)--10(-9) M) were markedly enhanced in their ability to generate superoxide (O2-) upon stimulation with either sodium fluoride or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	295-298	formyl peptide receptor 1	Homo sapiens	127-131
6971296-5	1981	The TPA nonresponsive variant TNR-2 cannot respond to epidermal growth factor; TNR-9 responds to this mitogen.	Tetradecanoylphorbol Acetate	4-7	tenascin R	Mus musculus	30-33
6167986-1	1981	gamma (immune) interferon (IFN-gamma) was induced in cultures of fresh human lymphocytes by combined treatment with a phorbol ester (12-O-tetradecanoylphorbol 13-acetate, TPA) and the T cell mitogen phytohemagglutinin (PHA).	Tetradecanoylphorbol Acetate	133-169	interferon gamma	Homo sapiens	27-36
6167986-1	1981	gamma (immune) interferon (IFN-gamma) was induced in cultures of fresh human lymphocytes by combined treatment with a phorbol ester (12-O-tetradecanoylphorbol 13-acetate, TPA) and the T cell mitogen phytohemagglutinin (PHA).	Tetradecanoylphorbol Acetate	171-174	interferon gamma	Homo sapiens	27-36
6167986-2	1981	Compared to the IFN-gamma yields obtained with PHA induction alone, the inclusion of TPA caused a significant enhancement of IFN-gamma production.	Tetradecanoylphorbol Acetate	85-88	interferon gamma	Homo sapiens	125-134
7278734-8	1981	Possible receptor sites for TPA are reviewed to include a hypothetical external membrane receptor, PLA2, pro- PLA2, and PLC, as well as the possible nature of the endogenous ligand at the "TPA receptor" to include a phospholipid and a polypeptide.	Tetradecanoylphorbol Acetate	28-31	phospholipase A2 group IB	Homo sapiens	99-103
7278734-8	1981	Possible receptor sites for TPA are reviewed to include a hypothetical external membrane receptor, PLA2, pro- PLA2, and PLC, as well as the possible nature of the endogenous ligand at the "TPA receptor" to include a phospholipid and a polypeptide.	Tetradecanoylphorbol Acetate	28-31	phospholipase A2 group IB	Homo sapiens	110-114
6971296-7	1981	TPA can modulate 125I-EGF binding to TNR-9 cells in a manner similar to its action on parental 3T3 cells.	Tetradecanoylphorbol Acetate	0-3	tenascin R	Mus musculus	37-40
6971296-8	1981	This TPA-induced alteration of EGF binding indicates that TNR-9 cells still interact with TPA, despite their inability to mount a mitogenic response.	Tetradecanoylphorbol Acetate	5-8	tenascin R	Mus musculus	58-61
6971296-8	1981	This TPA-induced alteration of EGF binding indicates that TNR-9 cells still interact with TPA, despite their inability to mount a mitogenic response.	Tetradecanoylphorbol Acetate	90-93	tenascin R	Mus musculus	58-61
6165014-1	1981	Human gamma (immune) interferon (IFN-gamma) was produced in lymphocyte cultures stimulated with a phorbol ester (12-O-tetradecanoylphorbol 13-acetate) and purified phytohemagglutinin.	Tetradecanoylphorbol Acetate	113-149	interferon gamma	Homo sapiens	33-42
6259208-3	1981	Production of superoxide anion (O2-) stimulated by concanavalin A or the chemotactic peptide formyl-methionyl-leucyl-phenylalanine FMLP was inhibited by DASA pretreatment, whereas O2- production stimulated by phorbol myristate acetate (PMA), sodium fluoride.	Tetradecanoylphorbol Acetate	209-234	formyl peptide receptor 1	Homo sapiens	131-135
6259208-3	1981	Production of superoxide anion (O2-) stimulated by concanavalin A or the chemotactic peptide formyl-methionyl-leucyl-phenylalanine FMLP was inhibited by DASA pretreatment, whereas O2- production stimulated by phorbol myristate acetate (PMA), sodium fluoride.	Tetradecanoylphorbol Acetate	236-239	formyl peptide receptor 1	Homo sapiens	131-135
7318151-2	1981	The treatment of adult mouse skin with 2 micrograms 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a sustained decrease in the basal levels of both SOD and catalase activities in the epidermis.	Tetradecanoylphorbol Acetate	52-88	catalase	Mus musculus	164-172
7318151-2	1981	The treatment of adult mouse skin with 2 micrograms 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a sustained decrease in the basal levels of both SOD and catalase activities in the epidermis.	Tetradecanoylphorbol Acetate	90-93	catalase	Mus musculus	164-172
7318151-4	1981	The alterations in both enzymes occurred against a high background of enhanced protein synthesis which indicates that the effect of TPA is selective for SOD and catalase.	Tetradecanoylphorbol Acetate	132-135	catalase	Mus musculus	153-169
7318151-7	1981	These results indicate that damage which favors neoplastic progression could occur in TPA-treated mouse skin due to the accumulation of free radicals resulting from low levels of SOD and catalase activity.	Tetradecanoylphorbol Acetate	86-89	catalase	Mus musculus	179-195
7318151-8	1981	In addition, the TPA-caused decrease in the levels of SOD and catalase was not prevented by either retinoic acid, fluocinolone acetonide, tosyl amino-2-phenylethyl chloromethyl ketone, or butylated hydroxytoluene, suggesting that inhibition of tumor promotion by these agents is not mediated through alterations in the levels of enzymatic activities which decrease free radical concentrations.	Tetradecanoylphorbol Acetate	17-20	catalase	Mus musculus	62-70
7326827-1	1981	Rapid, specific, saturable and partially reversible binding of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate ([3H]TPA) to a particulate fraction of mouse brain can be demonstrated by means of a "cold acetone-filter assay"; by washing with cold acetone at -20 degree C, nonspecific binding of the highly lipophilic [3H]TPA to membranes can be reduced to approximately 10% of the total binding.	Tetradecanoylphorbol Acetate	82-118	promotion susceptibility QTL 1	Mus musculus	124-127
7326827-1	1981	Rapid, specific, saturable and partially reversible binding of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate ([3H]TPA) to a particulate fraction of mouse brain can be demonstrated by means of a "cold acetone-filter assay"; by washing with cold acetone at -20 degree C, nonspecific binding of the highly lipophilic [3H]TPA to membranes can be reduced to approximately 10% of the total binding.	Tetradecanoylphorbol Acetate	82-118	promotion susceptibility QTL 1	Mus musculus	328-331
7350246-2	1980	Priming with LPS (1 microgram/ml) produced a sevenfold enhancement of PMA-stimulated O2- generation; priming was detected within 30 min and persisted for at least 4 d. Exposure to MDP (1 muM) primed the macrophages to double their O2- release; the response was first observed after 4 h and persisted for at least 3 d. The priming response was not observed with stereoisomers of MDP, which are inactive as adjuvants.	Tetradecanoylphorbol Acetate	70-73	toll-like receptor 4	Mus musculus	13-16
7219576-5	1981	These cells release mainly PGE2 and PGI2 (measured as its stable hydrolysis product 6-keto-PGF1 alpha) upon stimulation with the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	145-181	prostaglandin I receptor (IP)	Mus musculus	36-40
7219576-5	1981	These cells release mainly PGE2 and PGI2 (measured as its stable hydrolysis product 6-keto-PGF1 alpha) upon stimulation with the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	183-186	prostaglandin I receptor (IP)	Mus musculus	36-40
6933001-1	1980	The potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) was tested for its ability (a) to induce sister chromatid exchange, (b) to increase the rate of transition at the adenine phosphoribosyltransferase (apt) locus from the presumptive heterozygous state ((+/- to the homozygous state (-/ - or -), and (c) to enhance the frequency of mutations expressed after ultraviolet radiation mutagenesis.	Tetradecanoylphorbol Acetate	26-62	adenine phosphoribosyltransferase	Cricetulus griseus	183-216
6933001-1	1980	The potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) was tested for its ability (a) to induce sister chromatid exchange, (b) to increase the rate of transition at the adenine phosphoribosyltransferase (apt) locus from the presumptive heterozygous state ((+/- to the homozygous state (-/ - or -), and (c) to enhance the frequency of mutations expressed after ultraviolet radiation mutagenesis.	Tetradecanoylphorbol Acetate	64-67	adenine phosphoribosyltransferase	Cricetulus griseus	183-216
7004463-4	1980	12-0-tetradodecanoil phorbol 13-acetate (TPA) induced macrophagic differentiation of HL 60 cell line was also accompanied by a decrease of insulin binding activity.	Tetradecanoylphorbol Acetate	41-44	insulin	Homo sapiens	139-146
6778951-5	1980	Addition of the fatty acid derivative phorbol myristate acetate to mitogen-stimulated cultures increased Jurkat-FHCRC IL-2 production to concentrations &gt; 400 U/ml.	Tetradecanoylphorbol Acetate	38-63	interleukin 2	Homo sapiens	118-122
7193215-6	1980	Catalase, cytochrome C, histidine, and methionine inhibited the PMA-induced 51Cr-release by human neutrophils, whereas superoxide dismutase, myeloperoxidase inhibitors, and some hydroxyl radical scavengers or singlet oxygen quenchers had no effect.	Tetradecanoylphorbol Acetate	64-67	catalase	Homo sapiens	0-8
7193215-6	1980	Catalase, cytochrome C, histidine, and methionine inhibited the PMA-induced 51Cr-release by human neutrophils, whereas superoxide dismutase, myeloperoxidase inhibitors, and some hydroxyl radical scavengers or singlet oxygen quenchers had no effect.	Tetradecanoylphorbol Acetate	64-67	cytochrome c, somatic	Homo sapiens	10-22
33791017-11	2021	Perp and phorbol-12-myristate-13-acetate-induced protein 1 were demonstrated to have vital roles in the p53 signaling pathway which was indicated in the interaction network.	Tetradecanoylphorbol Acetate	9-40	tumor protein p53	Homo sapiens	104-107
6244567-4	1980	The ability of phorbol myristate acetate-stimulated monocytes to lyse erythrocyte targets was markedly impaired by catalase or superoxide dismutase but not by heat-inactivated enzymes or albumin.	Tetradecanoylphorbol Acetate	15-40	catalase	Homo sapiens	115-123
1182705-2	1975	This report presents results of a study on the effects of TPA on epidermal histidase (L-histidine ammonia lyase), an enzyme found in normal epidermis but not in dermis or in mouse squamous cell carcinomas.	Tetradecanoylphorbol Acetate	58-61	histidine ammonia lyase	Mus musculus	75-84
1182705-4	1975	Topical TPA treatment at doses active in tumor promotion (1.7 to 17.0 nmoles/application) produced dose-dependent decreases in epidermal histidase specific activity at 19 hr posttreatment.	Tetradecanoylphorbol Acetate	8-11	histidine ammonia lyase	Mus musculus	137-146
1182705-7	1975	The strong promoter TPA produced a greater histidase decrease than did the moderate promoter and mitogen 12,13-didecanoyl phorbol at equimolar dose, while phorbol, a nonpromoter and nonmitogen, produced no effects on histidase.	Tetradecanoylphorbol Acetate	20-23	histidine ammonia lyase	Mus musculus	43-52
1182705-7	1975	The strong promoter TPA produced a greater histidase decrease than did the moderate promoter and mitogen 12,13-didecanoyl phorbol at equimolar dose, while phorbol, a nonpromoter and nonmitogen, produced no effects on histidase.	Tetradecanoylphorbol Acetate	20-23	histidine ammonia lyase	Mus musculus	217-226
33729835-8	2021	Increased ERK activation by addition of phorbol myristate acetate (PMA) also reduced inflammation-associated myotube atrophy, and increased the interaction between dystrophin and beta-dystroglycan, which was partially attenuated in the presence of a phosphomimetic mutation at dystrophin S3059.	Tetradecanoylphorbol Acetate	40-65	mitogen-activated protein kinase 1	Mus musculus	10-13
33729835-8	2021	Increased ERK activation by addition of phorbol myristate acetate (PMA) also reduced inflammation-associated myotube atrophy, and increased the interaction between dystrophin and beta-dystroglycan, which was partially attenuated in the presence of a phosphomimetic mutation at dystrophin S3059.	Tetradecanoylphorbol Acetate	40-65	dystrophin, muscular dystrophy	Mus musculus	164-174
33729835-8	2021	Increased ERK activation by addition of phorbol myristate acetate (PMA) also reduced inflammation-associated myotube atrophy, and increased the interaction between dystrophin and beta-dystroglycan, which was partially attenuated in the presence of a phosphomimetic mutation at dystrophin S3059.	Tetradecanoylphorbol Acetate	40-65	dystrophin, muscular dystrophy	Mus musculus	277-287
33729835-8	2021	Increased ERK activation by addition of phorbol myristate acetate (PMA) also reduced inflammation-associated myotube atrophy, and increased the interaction between dystrophin and beta-dystroglycan, which was partially attenuated in the presence of a phosphomimetic mutation at dystrophin S3059.	Tetradecanoylphorbol Acetate	67-70	mitogen-activated protein kinase 1	Mus musculus	10-13
33729835-8	2021	Increased ERK activation by addition of phorbol myristate acetate (PMA) also reduced inflammation-associated myotube atrophy, and increased the interaction between dystrophin and beta-dystroglycan, which was partially attenuated in the presence of a phosphomimetic mutation at dystrophin S3059.	Tetradecanoylphorbol Acetate	67-70	dystrophin, muscular dystrophy	Mus musculus	164-174
33729835-8	2021	Increased ERK activation by addition of phorbol myristate acetate (PMA) also reduced inflammation-associated myotube atrophy, and increased the interaction between dystrophin and beta-dystroglycan, which was partially attenuated in the presence of a phosphomimetic mutation at dystrophin S3059.	Tetradecanoylphorbol Acetate	67-70	dystrophin, muscular dystrophy	Mus musculus	277-287
34013580-2	2021	METHODOLOGY: The human monocyte cell line (THP1) was differentiated into macrophages by exposure to phorbol myristate acetate (PMA) and the cultures were inoculated with E. faecalis for up to 48 h. At three time points- 90 min, 24 h, and 48 h after inoculation, the macrophages and their supernatants were examined.	Tetradecanoylphorbol Acetate	100-125	GLI family zinc finger 2	Homo sapiens	43-47
34013580-2	2021	METHODOLOGY: The human monocyte cell line (THP1) was differentiated into macrophages by exposure to phorbol myristate acetate (PMA) and the cultures were inoculated with E. faecalis for up to 48 h. At three time points- 90 min, 24 h, and 48 h after inoculation, the macrophages and their supernatants were examined.	Tetradecanoylphorbol Acetate	127-130	GLI family zinc finger 2	Homo sapiens	43-47
33281120-3	2021	Kaempferol suppressed the production and gene expression of MUC5AC mucins, induced by PMA through the inhibition of degradation of inhibitory kappa Balpha (IkappaBalpha), and NF-kappaB p65 nuclear translocation.	Tetradecanoylphorbol Acetate	86-89	NFKB inhibitor alpha	Homo sapiens	156-168
679197-1	1978	The tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA), a highly active comitogen in phytohemagglutinin-treated bovine lymphocytes, induces an 11-fold increase in ornithine decarboxylase activity over cultures treated with the lectin alone.	Tetradecanoylphorbol Acetate	26-62	ornithine decarboxylase	Bos taurus	177-200
679197-1	1978	The tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA), a highly active comitogen in phytohemagglutinin-treated bovine lymphocytes, induces an 11-fold increase in ornithine decarboxylase activity over cultures treated with the lectin alone.	Tetradecanoylphorbol Acetate	64-67	ornithine decarboxylase	Bos taurus	177-200
1245555-3	1976	These blocked cells could be induced to start making DNA within only one hour either by returning the ionic calcium level to a normal range of values (1.25 mM), or by adding 0.05 mug/ml of PMA (12-O-tetradecanoyl-phorbol-13-acetate).	Tetradecanoylphorbol Acetate	194-231	peroneal muscular atrophy	Mus musculus	189-192
33386632-6	2021	CS-DPSCs showed a lower increase in the rate of OCN expression among phorbol 12-myristate 13-acetate (PMA)-treated cells than healthy donor DPSCs compared with untreated control cells.	Tetradecanoylphorbol Acetate	69-100	bone gamma-carboxyglutamate protein	Homo sapiens	48-51
33386632-6	2021	CS-DPSCs showed a lower increase in the rate of OCN expression among phorbol 12-myristate 13-acetate (PMA)-treated cells than healthy donor DPSCs compared with untreated control cells.	Tetradecanoylphorbol Acetate	102-105	bone gamma-carboxyglutamate protein	Homo sapiens	48-51
33386632-7	2021	CS-DPSCs showed a lower phosphorylation rate of p38 and p44/42 in PMA-treated cells than healthy donor DPSCs compared with untreated control cells.	Tetradecanoylphorbol Acetate	66-69	mitogen-activated protein kinase 14	Homo sapiens	48-51
34051057-6	2021	Additionally, the administration of 12-O-tetradecanoylphorbol 13-acetate (TPA) and staurosporine (STS), activators of ERK signaling, also resulted in a decrease in the levels of both ChREBPalpha and beta mRNA in HepG2 cells through ERK signaling.	Tetradecanoylphorbol Acetate	36-72	mitogen-activated protein kinase 1	Homo sapiens	118-121
34051057-6	2021	Additionally, the administration of 12-O-tetradecanoylphorbol 13-acetate (TPA) and staurosporine (STS), activators of ERK signaling, also resulted in a decrease in the levels of both ChREBPalpha and beta mRNA in HepG2 cells through ERK signaling.	Tetradecanoylphorbol Acetate	36-72	mitogen-activated protein kinase 1	Homo sapiens	232-235
34051057-6	2021	Additionally, the administration of 12-O-tetradecanoylphorbol 13-acetate (TPA) and staurosporine (STS), activators of ERK signaling, also resulted in a decrease in the levels of both ChREBPalpha and beta mRNA in HepG2 cells through ERK signaling.	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 1	Homo sapiens	118-121
34051057-6	2021	Additionally, the administration of 12-O-tetradecanoylphorbol 13-acetate (TPA) and staurosporine (STS), activators of ERK signaling, also resulted in a decrease in the levels of both ChREBPalpha and beta mRNA in HepG2 cells through ERK signaling.	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 1	Homo sapiens	232-235
34038479-10	2021	PMA/ionomycin consistently induced high percentages of IL-4+ Th2 cells in both groups confirming that T cells of all horses studied were capable of IL-4 production.	Tetradecanoylphorbol Acetate	0-3	interleukin 4	Equus caballus	55-59
34038479-10	2021	PMA/ionomycin consistently induced high percentages of IL-4+ Th2 cells in both groups confirming that T cells of all horses studied were capable of IL-4 production.	Tetradecanoylphorbol Acetate	0-3	interleukin 4	Equus caballus	148-152
33953303-5	2021	In a cell-based assay using Adam10/17 double-knockout mouse embryonic fibroblasts (Adam10/17-/- mEFs) exogenously expressing each of these mutants, phorbol 12-myristate 13-acetate-stimulated shedding was strongly reduced compared with wild-type ADAM17.	Tetradecanoylphorbol Acetate	148-179	a disintegrin and metallopeptidase domain 17	Mus musculus	245-251
33957124-8	2021	Nevertheless, ADAM17Deltacyto could be stimulated by PMA, a well-characterized post-translational activator of ADAM17, corroborating that the cytoplasmic domain of endogenous ADAM17 is not required for its rapid response to PMA.	Tetradecanoylphorbol Acetate	53-56	a disintegrin and metallopeptidase domain 17	Mus musculus	14-20
33957124-8	2021	Nevertheless, ADAM17Deltacyto could be stimulated by PMA, a well-characterized post-translational activator of ADAM17, corroborating that the cytoplasmic domain of endogenous ADAM17 is not required for its rapid response to PMA.	Tetradecanoylphorbol Acetate	53-56	a disintegrin and metallopeptidase domain 17	Mus musculus	111-117
33957124-8	2021	Nevertheless, ADAM17Deltacyto could be stimulated by PMA, a well-characterized post-translational activator of ADAM17, corroborating that the cytoplasmic domain of endogenous ADAM17 is not required for its rapid response to PMA.	Tetradecanoylphorbol Acetate	53-56	a disintegrin and metallopeptidase domain 17	Mus musculus	111-117
33349924-9	2021	The patient responded well to anti-TNFalpha treatment, which may be linked to the capacity of TNFalpha to induce GM-CSF in PMA-treated PBMCs, while GM-CSF itself only induced dose-dependent IL-1Ra production.	Tetradecanoylphorbol Acetate	123-126	tumor necrosis factor	Homo sapiens	35-43
33349924-9	2021	The patient responded well to anti-TNFalpha treatment, which may be linked to the capacity of TNFalpha to induce GM-CSF in PMA-treated PBMCs, while GM-CSF itself only induced dose-dependent IL-1Ra production.	Tetradecanoylphorbol Acetate	123-126	tumor necrosis factor	Homo sapiens	94-102
33352199-10	2021	In ex vivo PMA/ionomycin-stimulated cultures of WC1- gammadelta T cells but not WC1+ produced both IL-17 and IFNgamma.	Tetradecanoylphorbol Acetate	11-14	interferon gamma	Capra hircus	109-117
33063558-4	2021	Phorbol myristate acetate (PMA) was added to induce NETs formation, which was quantified by measuring cell-free extracellular DNA (cf-DNA), myeloperoxidase-conjugated (MPO)-DNA and neutrophil elastase-conjugated (NE)-DNA, and confirmed by immunofluorescence labeling and imaging.	Tetradecanoylphorbol Acetate	0-25	myeloperoxidase	Homo sapiens	140-155
33063558-4	2021	Phorbol myristate acetate (PMA) was added to induce NETs formation, which was quantified by measuring cell-free extracellular DNA (cf-DNA), myeloperoxidase-conjugated (MPO)-DNA and neutrophil elastase-conjugated (NE)-DNA, and confirmed by immunofluorescence labeling and imaging.	Tetradecanoylphorbol Acetate	0-25	myeloperoxidase	Homo sapiens	168-171
33063558-4	2021	Phorbol myristate acetate (PMA) was added to induce NETs formation, which was quantified by measuring cell-free extracellular DNA (cf-DNA), myeloperoxidase-conjugated (MPO)-DNA and neutrophil elastase-conjugated (NE)-DNA, and confirmed by immunofluorescence labeling and imaging.	Tetradecanoylphorbol Acetate	27-30	myeloperoxidase	Homo sapiens	140-155
33760219-8	2021	BTK inhibitors [ibrutinib (10 microM), CNX-774 (10 microM)] significantly attenuated TPA-induced cell invasion and migration in MCF-7 cells and inhibited the activation of the phospholipase Cgamma2/PKCbeta signaling pathways.	Tetradecanoylphorbol Acetate	85-88	protein kinase C alpha	Homo sapiens	198-205
33760219-0	2021	Bruton"s agammaglobulinemia tyrosine kinase (Btk) regulates TPA-induced breast cancer cell invasion via PLCgamma2/PKCbeta/NF-kappaB/AP-1-dependent matrix metalloproteinase-9 activation.	Tetradecanoylphorbol Acetate	60-63	protein kinase C alpha	Homo sapiens	114-121
33890137-10	2021	Importantly, this study reveals the activation of ERK1/2 and PI3K/AKT pathway in PMA-induced Dami cell differentiation into MK.	Tetradecanoylphorbol Acetate	81-84	mitogen-activated protein kinase 3	Homo sapiens	50-56
33760219-0	2021	Bruton"s agammaglobulinemia tyrosine kinase (Btk) regulates TPA-induced breast cancer cell invasion via PLCgamma2/PKCbeta/NF-kappaB/AP-1-dependent matrix metalloproteinase-9 activation.	Tetradecanoylphorbol Acetate	60-63	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-136
33933922-2	2021	DESIGN: THP-1 monocytes were maintained in RPMI medium and transformed into M0 macrophages using Phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	97-128	GLI family zinc finger 2	Homo sapiens	8-13
33933922-2	2021	DESIGN: THP-1 monocytes were maintained in RPMI medium and transformed into M0 macrophages using Phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	130-133	GLI family zinc finger 2	Homo sapiens	8-13
33925858-7	2021	THP-1 monocytes were differentiated into macrophages by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) and co-treatment with 0.1 mg/mL CNDs.	Tetradecanoylphorbol Acetate	71-107	GLI family zinc finger 2	Homo sapiens	0-5
33890137-10	2021	Importantly, this study reveals the activation of ERK1/2 and PI3K/AKT pathway in PMA-induced Dami cell differentiation into MK.	Tetradecanoylphorbol Acetate	81-84	AKT serine/threonine kinase 1	Homo sapiens	66-69
33865856-4	2021	We report here that monomeric wild type (WT) mouse SK1 (GFP-mSK1) translocates to the PM of MCF-7L cells stimulated with carbachol or phorbol myristate acetate (PMA), whereas the dimer translocates to the PM in response to sphingosine 1-phosphate (S1P); thus, the equilibrium between monomer and dimer is sensitive to cellular stimulus.	Tetradecanoylphorbol Acetate	161-164	skin antigen 1	Mus musculus	60-64
33865428-8	2021	Furthermore, IL-35 markedly inhibited the phosphorylation levels of ERK1/2, p38, and JNK1/2, in PMA plus A23187 induced HMC-1 cells.	Tetradecanoylphorbol Acetate	96-99	mitogen-activated protein kinase 3	Homo sapiens	68-74
33865428-8	2021	Furthermore, IL-35 markedly inhibited the phosphorylation levels of ERK1/2, p38, and JNK1/2, in PMA plus A23187 induced HMC-1 cells.	Tetradecanoylphorbol Acetate	96-99	mitogen-activated protein kinase 1	Homo sapiens	76-79
33865428-8	2021	Furthermore, IL-35 markedly inhibited the phosphorylation levels of ERK1/2, p38, and JNK1/2, in PMA plus A23187 induced HMC-1 cells.	Tetradecanoylphorbol Acetate	96-99	mitogen-activated protein kinase 8	Homo sapiens	85-91
33865856-5	2021	In addition, carbachol and PMA induced translocation of monomeric GFP-mSK1 to lamellipodia, while S1P induced translocation of dimeric GFP-mSK1 to filopodia, suggesting that SK1 regulates different cell biological processes dependent on dimerization.	Tetradecanoylphorbol Acetate	27-30	skin antigen 1	Mus musculus	70-74
33992512-8	2021	In THP-1 cells treated with phorbol myristate acetate, GL inhibited the inflammatory polarization of macrophages (as evidenced by reduced TNF-alpha levels) via regulation of Notch1 and DLL4 pathways.	Tetradecanoylphorbol Acetate	28-53	tumor necrosis factor	Homo sapiens	138-147
33954180-9	2021	In TPA model, both hydrocortisone and emollient significantly decreased expression levels of IL-1alpha, IL-1beta, IL-6, and TNFalpha mRNA.	Tetradecanoylphorbol Acetate	3-6	interleukin 6	Mus musculus	114-118
33954180-9	2021	In TPA model, both hydrocortisone and emollient significantly decreased expression levels of IL-1alpha, IL-1beta, IL-6, and TNFalpha mRNA.	Tetradecanoylphorbol Acetate	3-6	tumor necrosis factor	Mus musculus	124-132
33992512-8	2021	In THP-1 cells treated with phorbol myristate acetate, GL inhibited the inflammatory polarization of macrophages (as evidenced by reduced TNF-alpha levels) via regulation of Notch1 and DLL4 pathways.	Tetradecanoylphorbol Acetate	28-53	notch receptor 1	Homo sapiens	174-180
33649318-2	2021	Here, we show that by utilizing triphenylamine (TPA) as an electronic donor that connects to an acceptor via an sp3 linker, six TPA-based AIE-active RTP luminophores were obtained.	Tetradecanoylphorbol Acetate	48-51	Sp3 transcription factor	Homo sapiens	112-115
33676894-6	2021	Kv1.5, but not Kv1.1, Kv1.2, Kv1.3 or Kv1.4, was uniquely sensitive to PMA treatment.	Tetradecanoylphorbol Acetate	71-74	potassium voltage-gated channel subfamily A member 5	Homo sapiens	0-5
33676894-6	2021	Kv1.5, but not Kv1.1, Kv1.2, Kv1.3 or Kv1.4, was uniquely sensitive to PMA treatment.	Tetradecanoylphorbol Acetate	71-74	potassium voltage-gated channel subfamily A member 2	Homo sapiens	22-27
33129947-12	2021	In an in vitro study, CJT pretreatment suppressed the LPS-induced TNF-alpha secretion in RAW264.7 cells and attenuated the PMA-induced IL-6, IL-8 and MCP-1 secretion in A549 cells.	Tetradecanoylphorbol Acetate	123-126	interleukin 6	Mus musculus	135-139
33387144-5	2021	THP-1 monocytes were incubated with phorbol 12-myristate-13-acetate (PMA) to differentiate into macrophages, and then incubated with LPS and IS for 24 h. ELISA was used to detect the levels of TNFalpha, IL-6, IL-1beta in THP-1-derived macrophages.	Tetradecanoylphorbol Acetate	36-67	GLI family zinc finger 2	Homo sapiens	0-5
33387144-5	2021	THP-1 monocytes were incubated with phorbol 12-myristate-13-acetate (PMA) to differentiate into macrophages, and then incubated with LPS and IS for 24 h. ELISA was used to detect the levels of TNFalpha, IL-6, IL-1beta in THP-1-derived macrophages.	Tetradecanoylphorbol Acetate	69-72	GLI family zinc finger 2	Homo sapiens	0-5
33521906-12	2021	Two of these studies related the adverse events to the co-administration of EPO with tPA.	Tetradecanoylphorbol Acetate	85-88	erythropoietin	Homo sapiens	76-79
33514282-4	2021	Exposure of phorbol-12-myristate-13-acetate (PMA)-differentiated THP1 macrophages to the secretome of CSF conditioned ADSCs downregulated both pro-inflammatory (COX-2, TNFalpha) and anti-inflammatory (SOCS3, IL1RA, TGFbeta) genes in these cells.	Tetradecanoylphorbol Acetate	12-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
33514282-4	2021	Exposure of phorbol-12-myristate-13-acetate (PMA)-differentiated THP1 macrophages to the secretome of CSF conditioned ADSCs downregulated both pro-inflammatory (COX-2, TNFalpha) and anti-inflammatory (SOCS3, IL1RA, TGFbeta) genes in these cells.	Tetradecanoylphorbol Acetate	12-43	tumor necrosis factor	Homo sapiens	168-176
33514282-4	2021	Exposure of phorbol-12-myristate-13-acetate (PMA)-differentiated THP1 macrophages to the secretome of CSF conditioned ADSCs downregulated both pro-inflammatory (COX-2, TNFalpha) and anti-inflammatory (SOCS3, IL1RA, TGFbeta) genes in these cells.	Tetradecanoylphorbol Acetate	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
33514282-4	2021	Exposure of phorbol-12-myristate-13-acetate (PMA)-differentiated THP1 macrophages to the secretome of CSF conditioned ADSCs downregulated both pro-inflammatory (COX-2, TNFalpha) and anti-inflammatory (SOCS3, IL1RA, TGFbeta) genes in these cells.	Tetradecanoylphorbol Acetate	45-48	tumor necrosis factor	Homo sapiens	168-176
33649318-2	2021	Here, we show that by utilizing triphenylamine (TPA) as an electronic donor that connects to an acceptor via an sp3 linker, six TPA-based AIE-active RTP luminophores were obtained.	Tetradecanoylphorbol Acetate	128-131	Sp3 transcription factor	Homo sapiens	112-115
33528492-6	2021	Furthermore, we also demonstrated that inhibiting the PKCalpha/ERK signaling pathway reversed the reduction of C7ORF41 in TPA-induced keratinocytes, indicating that C7ORF41 expression could be regulated by upstream PKCalpha/ERK signaling pathway during keratinocyte differentiation.	Tetradecanoylphorbol Acetate	122-125	protein kinase C alpha	Homo sapiens	54-62
33528492-6	2021	Furthermore, we also demonstrated that inhibiting the PKCalpha/ERK signaling pathway reversed the reduction of C7ORF41 in TPA-induced keratinocytes, indicating that C7ORF41 expression could be regulated by upstream PKCalpha/ERK signaling pathway during keratinocyte differentiation.	Tetradecanoylphorbol Acetate	122-125	mitogen-activated protein kinase 1	Homo sapiens	63-66
33528492-6	2021	Furthermore, we also demonstrated that inhibiting the PKCalpha/ERK signaling pathway reversed the reduction of C7ORF41 in TPA-induced keratinocytes, indicating that C7ORF41 expression could be regulated by upstream PKCalpha/ERK signaling pathway during keratinocyte differentiation.	Tetradecanoylphorbol Acetate	122-125	protein kinase C alpha	Homo sapiens	215-223
33528492-6	2021	Furthermore, we also demonstrated that inhibiting the PKCalpha/ERK signaling pathway reversed the reduction of C7ORF41 in TPA-induced keratinocytes, indicating that C7ORF41 expression could be regulated by upstream PKCalpha/ERK signaling pathway during keratinocyte differentiation.	Tetradecanoylphorbol Acetate	122-125	mitogen-activated protein kinase 1	Homo sapiens	224-227
33717069-7	2021	Overexpression of LOC645166 in Jurkat cells down-regulated the IL-23p19 expression and suppressed the JAK2/STAT3 signaling in response to stimulation by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	153-184	signal transducer and activator of transcription 3	Homo sapiens	107-112
33578967-11	2021	The diterpenoid-induced inhibition of AQP1-4 expression was blocked by phorbol-12-myristate-13-acetate (PMA; agonist of PKC).	Tetradecanoylphorbol Acetate	71-102	protein kinase C, alpha	Mus musculus	120-123
33578967-11	2021	The diterpenoid-induced inhibition of AQP1-4 expression was blocked by phorbol-12-myristate-13-acetate (PMA; agonist of PKC).	Tetradecanoylphorbol Acetate	104-107	protein kinase C, alpha	Mus musculus	120-123
33557943-6	2021	By using this antibody as a tool, we showed that protein kinase C (PKC)-mediated Dab2-pSer24 was a conservative signaling event when human platelets were activated by the platelet agonists such as thrombin, collagen, ADP, 12-O-tetradecanoylphorbol-13-acetate, and the thromboxane A2 activator U46619.	Tetradecanoylphorbol Acetate	222-258	coagulation factor II, thrombin	Homo sapiens	197-205
33479893-4	2021	Since the production of IL-10 by B cells is not only a weapon to counteract the adverse effect of pro-inflammatory cytokines but also a response to cellular activation, we focused on those B cells that are prone to IL-10 production and detectable following a short-term stimulation with phorbol-12-myristate-13-acetate, ionomycin, and lipopolysaccharide (murine system) or CpG (human system).	Tetradecanoylphorbol Acetate	287-318	interleukin 10	Mus musculus	24-29
33443102-7	2021	Finally, we found that silencing of PKCalpha, but not PKCdelta, inhibits phorbol-12-myristate-13-acetate (PMA)-induced cytoplasmic enrichment of KRIT1, suggesting a major role for PKCalpha in regulating KRIT1 nucleocytoplasmic shuttling.	Tetradecanoylphorbol Acetate	73-104	protein kinase C alpha	Homo sapiens	36-44
33443102-7	2021	Finally, we found that silencing of PKCalpha, but not PKCdelta, inhibits phorbol-12-myristate-13-acetate (PMA)-induced cytoplasmic enrichment of KRIT1, suggesting a major role for PKCalpha in regulating KRIT1 nucleocytoplasmic shuttling.	Tetradecanoylphorbol Acetate	73-104	protein kinase C alpha	Homo sapiens	180-188
33443102-7	2021	Finally, we found that silencing of PKCalpha, but not PKCdelta, inhibits phorbol-12-myristate-13-acetate (PMA)-induced cytoplasmic enrichment of KRIT1, suggesting a major role for PKCalpha in regulating KRIT1 nucleocytoplasmic shuttling.	Tetradecanoylphorbol Acetate	106-109	protein kinase C alpha	Homo sapiens	36-44
33443102-7	2021	Finally, we found that silencing of PKCalpha, but not PKCdelta, inhibits phorbol-12-myristate-13-acetate (PMA)-induced cytoplasmic enrichment of KRIT1, suggesting a major role for PKCalpha in regulating KRIT1 nucleocytoplasmic shuttling.	Tetradecanoylphorbol Acetate	106-109	protein kinase C alpha	Homo sapiens	180-188
33531766-2	2021	Methods  We did a retrospective chart review of all the patients who received emergent MRI brain during a stroke alert to help make decision about intravenous tissue-type plasminogen activator (IV tPA) administration from January 2013 to December 2015.	Tetradecanoylphorbol Acetate	197-200	plasminogen activator, tissue type	Homo sapiens	159-192
33307168-4	2021	In this study, we found mtROS generation and phosphorylation of MAPKs were mediated by PKCdelta in HCCs treated with the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	136-173	holocytochrome c synthase	Homo sapiens	99-103
33307168-4	2021	In this study, we found mtROS generation and phosphorylation of MAPKs were mediated by PKCdelta in HCCs treated with the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	175-178	holocytochrome c synthase	Homo sapiens	99-103
33307168-5	2021	Heat shock protein 60 (HSP60), one of the chaperones in mitochondria was the major protein oxidized in TPA-treated HCCs.	Tetradecanoylphorbol Acetate	103-106	holocytochrome c synthase	Homo sapiens	115-119
33307168-9	2021	Moreover, TPA induced opposite phenotypical changes of HCCs, G1 cell cycle arrest, and cell migration, which were prevented by mtROS scavengers and depletion of PKCdelta and HSP60.	Tetradecanoylphorbol Acetate	10-13	holocytochrome c synthase	Homo sapiens	55-59
33307168-10	2021	Consistently, TPA increased the migration-related genes, hydrogen peroxide inducible clone5, matrix metalloproteinase-1/3, laminingamma2, and suppressed the cell cycle regulator cyclin E1 (CCNE1) via PKCdelta/mtROS/HSP60/MAPK-axis.	Tetradecanoylphorbol Acetate	14-17	matrix metallopeptidase 13	Homo sapiens	93-121
33239332-5	2021	A 48-h exposure to the potent PKC activator phorbol 12-myristate 13-acetate (PMA) at 10 nM concentration reduced the intensity of alpha-smooth muscle actin staining by 56% and periostin mRNA levels by 60% compared to control.	Tetradecanoylphorbol Acetate	44-75	periostin, osteoblast specific factor	Mus musculus	176-185
33239332-5	2021	A 48-h exposure to the potent PKC activator phorbol 12-myristate 13-acetate (PMA) at 10 nM concentration reduced the intensity of alpha-smooth muscle actin staining by 56% and periostin mRNA levels by 60% compared to control.	Tetradecanoylphorbol Acetate	77-80	periostin, osteoblast specific factor	Mus musculus	176-185
33011272-3	2020	Activation of NADPH oxidase-2 (NOX-2) in neutrophils by stimulators of protein kinase C (PKC), such as phorbol myristate acetate (PMA), results in the rapid generation of superoxide at the expense of oxidation of NADPH to NADP+.	Tetradecanoylphorbol Acetate	103-128	proline rich transmembrane protein 2	Homo sapiens	71-87
33374788-5	2020	It also inhibited IL-2 mRNA expression and NF-kappaB signaling mediated by phorbol 12-myristate 13-acetate, and phytohemagglutinin.	Tetradecanoylphorbol Acetate	75-106	interleukin 2	Homo sapiens	18-22
33374788-5	2020	It also inhibited IL-2 mRNA expression and NF-kappaB signaling mediated by phorbol 12-myristate 13-acetate, and phytohemagglutinin.	Tetradecanoylphorbol Acetate	75-106	nuclear factor kappa B subunit 1	Homo sapiens	43-52
33166892-5	2020	It was found that lysozyme adsorption capacity increased with increasing IC till reaching a plateau (390 mg/mL) over IC=540 mmol/L (FF-pMA-540), while there was an optimum IC (320 mmol/L, FF-pMA-320) at which gamma-globulin adsorption capacity reached the highest (208 mg/mL).	Tetradecanoylphorbol Acetate	135-138	lysozyme	Homo sapiens	18-26
33291656-9	2020	The association of hypoxia-inducible factor 1-alpha (HIF-1alpha)-nuclear factor kappa-light-chain-enhancer of activated b cells (NF-kappaB) crosstalk triggered by PMA enhanced PKCalpha-ERK1/2-NF-kappaB pathway; its activation was also significantly counteracted after TAN treatment.	Tetradecanoylphorbol Acetate	163-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-51
33291656-9	2020	The association of hypoxia-inducible factor 1-alpha (HIF-1alpha)-nuclear factor kappa-light-chain-enhancer of activated b cells (NF-kappaB) crosstalk triggered by PMA enhanced PKCalpha-ERK1/2-NF-kappaB pathway; its activation was also significantly counteracted after TAN treatment.	Tetradecanoylphorbol Acetate	163-166	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63
33291656-9	2020	The association of hypoxia-inducible factor 1-alpha (HIF-1alpha)-nuclear factor kappa-light-chain-enhancer of activated b cells (NF-kappaB) crosstalk triggered by PMA enhanced PKCalpha-ERK1/2-NF-kappaB pathway; its activation was also significantly counteracted after TAN treatment.	Tetradecanoylphorbol Acetate	163-166	nuclear factor kappa B subunit 1	Homo sapiens	129-138
33291656-9	2020	The association of hypoxia-inducible factor 1-alpha (HIF-1alpha)-nuclear factor kappa-light-chain-enhancer of activated b cells (NF-kappaB) crosstalk triggered by PMA enhanced PKCalpha-ERK1/2-NF-kappaB pathway; its activation was also significantly counteracted after TAN treatment.	Tetradecanoylphorbol Acetate	163-166	nuclear factor kappa B subunit 1	Homo sapiens	192-201
33074126-3	2021	In this study, our data showed that phorbol 12-myristate 13-acetate (PMA) treatment induced human leukemia monocytic cells (ThP-1) differentiation to M0 macrophages.	Tetradecanoylphorbol Acetate	36-67	GLI family zinc finger 2	Homo sapiens	124-129
33074126-3	2021	In this study, our data showed that phorbol 12-myristate 13-acetate (PMA) treatment induced human leukemia monocytic cells (ThP-1) differentiation to M0 macrophages.	Tetradecanoylphorbol Acetate	69-72	GLI family zinc finger 2	Homo sapiens	124-129
33074126-5	2021	An intermitted removal of PMA treatment reduced the mRNA levels of STC1 and TNFalpha but had no noticeable effects on the anti-inflammatory markers.	Tetradecanoylphorbol Acetate	26-29	tumor necrosis factor	Homo sapiens	76-84
33074126-8	2021	Moreover, LPS/IFNgamma-induced M1-polarization showed remarkably higher expression levels of STC1 than IL-4/IL-13-induced M2-macrophages and PMA-induced M0-macrophages.	Tetradecanoylphorbol Acetate	141-144	interferon gamma	Homo sapiens	14-22
33011272-3	2020	Activation of NADPH oxidase-2 (NOX-2) in neutrophils by stimulators of protein kinase C (PKC), such as phorbol myristate acetate (PMA), results in the rapid generation of superoxide at the expense of oxidation of NADPH to NADP+.	Tetradecanoylphorbol Acetate	103-128	proline rich transmembrane protein 2	Homo sapiens	89-92
33011272-3	2020	Activation of NADPH oxidase-2 (NOX-2) in neutrophils by stimulators of protein kinase C (PKC), such as phorbol myristate acetate (PMA), results in the rapid generation of superoxide at the expense of oxidation of NADPH to NADP+.	Tetradecanoylphorbol Acetate	130-133	proline rich transmembrane protein 2	Homo sapiens	71-87
33011272-3	2020	Activation of NADPH oxidase-2 (NOX-2) in neutrophils by stimulators of protein kinase C (PKC), such as phorbol myristate acetate (PMA), results in the rapid generation of superoxide at the expense of oxidation of NADPH to NADP+.	Tetradecanoylphorbol Acetate	130-133	proline rich transmembrane protein 2	Homo sapiens	89-92
33011272-7	2020	PMA-induced depletion of NAD+ in neutrophils was blocked by PKC inhibitors, but was not dependent on NOX-2, as it was not blocked by the NOX inhibitor, diphenyleneiodonium.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	60-63
30758988-0	2020	Effect of essential oil from Ageratum fastigiatum on beta-integrin (CD18) expression on human lymphocytes stimulated with phorbol myristate acetate in vitro.	Tetradecanoylphorbol Acetate	122-147	integrin subunit beta 2	Homo sapiens	68-72
32956670-6	2020	In HeLaCx43 cells treated with PMA to activate Pyk2, a decrease in Cx43 GJ intercellular communication (GJIC) was observed when assayed by dye transfer.	Tetradecanoylphorbol Acetate	31-34	protein tyrosine kinase 2 beta	Rattus norvegicus	47-51
32956670-6	2020	In HeLaCx43 cells treated with PMA to activate Pyk2, a decrease in Cx43 GJ intercellular communication (GJIC) was observed when assayed by dye transfer.	Tetradecanoylphorbol Acetate	31-34	gap junction protein, alpha 1	Rattus norvegicus	7-11
32956670-9	2020	The ability of Pyk2 and Src inhibitors to restore Cx43 function in the presence of PMA was also observed in NRVMs.	Tetradecanoylphorbol Acetate	83-86	protein tyrosine kinase 2 beta	Rattus norvegicus	15-19
32956670-9	2020	The ability of Pyk2 and Src inhibitors to restore Cx43 function in the presence of PMA was also observed in NRVMs.	Tetradecanoylphorbol Acetate	83-86	gap junction protein, alpha 1	Rattus norvegicus	50-54
32865287-9	2020	In plasma obtained from LPS- or PMA-stimulated whole blood, elevated MPO antigen levels inversely correlated with the ability of tinzaparin to inhibit 22Rv1-induced thrombin generation.	Tetradecanoylphorbol Acetate	32-35	myeloperoxidase	Homo sapiens	69-72
33173997-12	2020	Phorbol 12-myristate 13-acetate, an NF-kappaB pathway activator, reversed the inhibitory effect of C1q on inflammation, macrophage infiltration and mesangial cell (MC) proliferation in renal tissues of LN mice.	Tetradecanoylphorbol Acetate	0-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	36-45
30758988-6	2020	On in vitro tests, 6.25 x 10-3 and 12.5 x 10-3 microL/mL EOAF reduced CD18 frequency on phorbol-12-myristate-13-acetate (PMA)-stimulated lymphocytes.	Tetradecanoylphorbol Acetate	88-119	integrin subunit beta 2	Homo sapiens	70-74
30758988-6	2020	On in vitro tests, 6.25 x 10-3 and 12.5 x 10-3 microL/mL EOAF reduced CD18 frequency on phorbol-12-myristate-13-acetate (PMA)-stimulated lymphocytes.	Tetradecanoylphorbol Acetate	121-124	integrin subunit beta 2	Homo sapiens	70-74
33239616-8	2020	Consistently, we find that the CCL3-CCR5 axis suppresses PMA-induced enhancement of MMP-9 expression in macrophages.	Tetradecanoylphorbol Acetate	57-60	chemokine (C-C motif) receptor 5	Mus musculus	36-40
33187327-4	2020	The Exo were isolated from lipopolysaccharide (LPS)-stimulated phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages.	Tetradecanoylphorbol Acetate	63-94	GLI family zinc finger 2	Homo sapiens	116-121
32602900-7	2020	In cell line models, PD-L1 expression was found to be significantly enhanced in phorbol-12-myristate 13-acetate activated THP-1 human monocytes (macrophages) treated with LPS or incubated in conditioned media (CM) generated by non-small cell lung cancer (NSCLC) cells.	Tetradecanoylphorbol Acetate	80-111	GLI family zinc finger 2	Homo sapiens	122-127
33187327-4	2020	The Exo were isolated from lipopolysaccharide (LPS)-stimulated phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages.	Tetradecanoylphorbol Acetate	96-99	GLI family zinc finger 2	Homo sapiens	116-121
33144667-4	2020	Tetracycline-inducible BACH2 expression resulted in suppression of phorbol 12-myristate 13-acetate (PMA)/ionomycin-driven activation of a luciferase reporter containing BACH2/AP-1 target sequences from the mouse Ifng + 18k enhancer.	Tetradecanoylphorbol Acetate	67-98	interferon gamma	Mus musculus	212-216
33144667-4	2020	Tetracycline-inducible BACH2 expression resulted in suppression of phorbol 12-myristate 13-acetate (PMA)/ionomycin-driven activation of a luciferase reporter containing BACH2/AP-1 target sequences from the mouse Ifng + 18k enhancer.	Tetradecanoylphorbol Acetate	100-103	interferon gamma	Mus musculus	212-216
32693110-11	2020	By contrast PMA-induced ROS production by neutrophil adherent to either fibrinogen or polylysine was independent from Pyk2.	Tetradecanoylphorbol Acetate	12-15	fibrinogen beta chain	Homo sapiens	72-82
33182021-11	2020	NEAT1 expression in Jurkat cells was induced by PMA/ionomycin stimulation upon activation of the TCR-p38 pathway.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 1	Homo sapiens	101-104
33182021-13	2020	Knocking down NEAT1 expression with an ASO suppressed the expression of CXCL8 and TNF-alpha in PMA/ionomycin-stimulated Jurkat cells.	Tetradecanoylphorbol Acetate	95-98	C-X-C motif chemokine ligand 8	Homo sapiens	72-77
33182021-13	2020	Knocking down NEAT1 expression with an ASO suppressed the expression of CXCL8 and TNF-alpha in PMA/ionomycin-stimulated Jurkat cells.	Tetradecanoylphorbol Acetate	95-98	tumor necrosis factor	Homo sapiens	82-91
33154638-0	2020	Silver Citrate Nanoparticles Inhibit PMA-Induced TNFalpha Expression via Deactivation of NF-kappaB Activity in Human Cancer Cell-Lines, MCF-7.	Tetradecanoylphorbol Acetate	37-40	tumor necrosis factor	Homo sapiens	49-57
33154638-0	2020	Silver Citrate Nanoparticles Inhibit PMA-Induced TNFalpha Expression via Deactivation of NF-kappaB Activity in Human Cancer Cell-Lines, MCF-7.	Tetradecanoylphorbol Acetate	37-40	nuclear factor kappa B subunit 1	Homo sapiens	89-98
33154638-10	2020	The AgNPs-CIT were found to be non-toxic to MCF-7 cell-lines and inhibited PMA-induced activation of the NF-kappaBp65, and also the mRNA/protein expression of TNFalpha.	Tetradecanoylphorbol Acetate	75-78	tumor necrosis factor	Homo sapiens	159-167
33114591-4	2020	We show that venom treatment had a significant immunosuppressive effect, inhibiting the secretion of interleukin (IL)-2 and tumor necrosis factor (TNF) from purified human T cells by 90% or greater following stimulation with mitogen (phorbol 12-myristate 13-acetate and ionomycin) or via cluster of differentiation (CD) receptors, CD3/CD28.	Tetradecanoylphorbol Acetate	234-265	interleukin 2	Homo sapiens	101-119
33114591-4	2020	We show that venom treatment had a significant immunosuppressive effect, inhibiting the secretion of interleukin (IL)-2 and tumor necrosis factor (TNF) from purified human T cells by 90% or greater following stimulation with mitogen (phorbol 12-myristate 13-acetate and ionomycin) or via cluster of differentiation (CD) receptors, CD3/CD28.	Tetradecanoylphorbol Acetate	234-265	tumor necrosis factor	Homo sapiens	124-145
33114591-4	2020	We show that venom treatment had a significant immunosuppressive effect, inhibiting the secretion of interleukin (IL)-2 and tumor necrosis factor (TNF) from purified human T cells by 90% or greater following stimulation with mitogen (phorbol 12-myristate 13-acetate and ionomycin) or via cluster of differentiation (CD) receptors, CD3/CD28.	Tetradecanoylphorbol Acetate	234-265	tumor necrosis factor	Homo sapiens	147-150
33633511-4	2020	The study has been conducted with 2 objectives: examine the anti-inflammatory effect in vitro and the capacity of 2 unitary medicines, TNF-alpha (27 CH) and IL-1beta (27 CH), to reduce the secretion of TNF-alpha in human primary monocytes and THP-1 cells differentiated with phorbol-12-myristate-13-acetate, after lipopolysaccharide (LPS) exposure; then, investigate the presence of particles possibly containing starting materials using tunable resistive pulse sensing technique.	Tetradecanoylphorbol Acetate	275-306	tumor necrosis factor	Homo sapiens	135-144
33633511-4	2020	The study has been conducted with 2 objectives: examine the anti-inflammatory effect in vitro and the capacity of 2 unitary medicines, TNF-alpha (27 CH) and IL-1beta (27 CH), to reduce the secretion of TNF-alpha in human primary monocytes and THP-1 cells differentiated with phorbol-12-myristate-13-acetate, after lipopolysaccharide (LPS) exposure; then, investigate the presence of particles possibly containing starting materials using tunable resistive pulse sensing technique.	Tetradecanoylphorbol Acetate	275-306	tumor necrosis factor	Homo sapiens	202-211
33229509-10	2020	To complete the analysis of the CXCL10/CXCL11/CXCR3 axis, we activated miR-34a-5p transfected CD4+ and CD8+ T cells by PMA/Ionomycin and found reduced levels of endogenous CXCR3 and CXCR3 on the cell surface.	Tetradecanoylphorbol Acetate	119-122	CD4 molecule	Homo sapiens	94-97
32957051-9	2020	The shift of endometrial NK cells to the NK2 phenotype was more pronounced when stimulated by semen than by PMA/ionomycin.	Tetradecanoylphorbol Acetate	108-111	NK2 homeobox 1	Homo sapiens	41-44
33361040-10	2020	Tumors were formed in mice with SCID after injecting TPA-GES-1-BARF1 cell groups.	Tetradecanoylphorbol Acetate	53-56	BaRF1	Human gammaherpesvirus 4	63-68
33361040-12	2020	CONCLUSION: GES-1-BARF1 cells malignant transformation was induced by transfected BARF1 gene and TPA stimulation.	Tetradecanoylphorbol Acetate	97-100	BaRF1	Human gammaherpesvirus 4	18-23
33023539-5	2020	The expression of Egr2 and FasL, and the phosphorylation of AKT and ERK, after ionomycin and PMA co-stimulation, was detected, while the Ca2+ mobilization stimulated by K+ solution was determined.	Tetradecanoylphorbol Acetate	93-96	AKT serine/threonine kinase 1	Homo sapiens	60-63
33023539-5	2020	The expression of Egr2 and FasL, and the phosphorylation of AKT and ERK, after ionomycin and PMA co-stimulation, was detected, while the Ca2+ mobilization stimulated by K+ solution was determined.	Tetradecanoylphorbol Acetate	93-96	mitogen-activated protein kinase 1	Homo sapiens	68-71
32640883-5	2020	Mechanistic studies showed that the combined effects of DTC and TPA were associated with a decrease in Bcl-2.	Tetradecanoylphorbol Acetate	64-67	BCL2 apoptosis regulator	Homo sapiens	103-108
33090557-6	2020	Following ex vivo stimulation with phorbol myristate acetate/ionomycin, PSC patients showed significantly increased numbers of IL-17A-producing peripheral blood CD4+ T cells compared to PBC patients and healthy controls, indicating increased Th17 differentiation in vivo.	Tetradecanoylphorbol Acetate	35-60	CD4 molecule	Homo sapiens	161-164
32985604-0	2020	12-O-Tetradecanoylphorbol-13-acetate increases cardiomyogenesis through PKC/ERK signaling.	Tetradecanoylphorbol Acetate	0-36	mitogen-activated protein kinase 1	Mus musculus	76-79
30908093-3	2020	Phenylethanoids, acteoside (5) and isoacteoside (6) showed significant inhibitory to IL-2 secretion of with respect to phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells.	Tetradecanoylphorbol Acetate	119-144	interleukin 2	Homo sapiens	85-89
32662567-9	2020	Conversely, beta-elemene effectively inhibits inflammation, cell proliferation events, and enhances proapoptotic factors, by suppression of NF-kappaB transcriptional activation in DMBA/TPA animals.	Tetradecanoylphorbol Acetate	185-188	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	140-149
32986722-7	2020	Stimulation with PMA restored signaling and (with ionomycin) IL-2 production.	Tetradecanoylphorbol Acetate	17-20	interleukin 2	Homo sapiens	61-65
32985604-4	2020	The mechanism of TPA action is mediated by the induction of extracellular signal-regulated kinase (ERK) activity and the subsequent phosphorylation of GATA4 transcription factor.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase 1	Mus musculus	60-97
32985604-4	2020	The mechanism of TPA action is mediated by the induction of extracellular signal-regulated kinase (ERK) activity and the subsequent phosphorylation of GATA4 transcription factor.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase 1	Mus musculus	99-102
32448093-4	2020	The active mixture also reduced the production of PGE2 and IL-8 in PMA-induced A549 cells.	Tetradecanoylphorbol Acetate	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
32913271-4	2020	In the patients with T2D (DM), multifunctionality of circulating CD8 + PD-1 + T cells stimulated with PMA/ionomycin as well as with HLA-A*24:02 CMV peptide was dampened, while metformin recovered multifunctionality.	Tetradecanoylphorbol Acetate	102-105	MHC class I antigen 1	Sus scrofa	71-75
32912211-6	2020	Further, Tax and M22 protein expression were strongly enhanced by 12-O-Tetradecanoylphorbol-13-Acetate [TPA; Phorbol 12-myristate 13-acetate (PMA)]/ ionomycin, inducers of NF-kappaB and cytokine signaling, but not by tumor necrosis factor alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	66-102	nuclear factor kappa B subunit 1	Homo sapiens	172-181
32912211-6	2020	Further, Tax and M22 protein expression were strongly enhanced by 12-O-Tetradecanoylphorbol-13-Acetate [TPA; Phorbol 12-myristate 13-acetate (PMA)]/ ionomycin, inducers of NF-kappaB and cytokine signaling, but not by tumor necrosis factor alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	66-102	tumor necrosis factor	Homo sapiens	217-244
32912211-6	2020	Further, Tax and M22 protein expression were strongly enhanced by 12-O-Tetradecanoylphorbol-13-Acetate [TPA; Phorbol 12-myristate 13-acetate (PMA)]/ ionomycin, inducers of NF-kappaB and cytokine signaling, but not by tumor necrosis factor alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	66-102	tumor necrosis factor	Homo sapiens	246-255
32912211-6	2020	Further, Tax and M22 protein expression were strongly enhanced by 12-O-Tetradecanoylphorbol-13-Acetate [TPA; Phorbol 12-myristate 13-acetate (PMA)]/ ionomycin, inducers of NF-kappaB and cytokine signaling, but not by tumor necrosis factor alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	104-107	nuclear factor kappa B subunit 1	Homo sapiens	172-181
32912211-6	2020	Further, Tax and M22 protein expression were strongly enhanced by 12-O-Tetradecanoylphorbol-13-Acetate [TPA; Phorbol 12-myristate 13-acetate (PMA)]/ ionomycin, inducers of NF-kappaB and cytokine signaling, but not by tumor necrosis factor alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	104-107	tumor necrosis factor	Homo sapiens	217-244
32912211-6	2020	Further, Tax and M22 protein expression were strongly enhanced by 12-O-Tetradecanoylphorbol-13-Acetate [TPA; Phorbol 12-myristate 13-acetate (PMA)]/ ionomycin, inducers of NF-kappaB and cytokine signaling, but not by tumor necrosis factor alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	104-107	tumor necrosis factor	Homo sapiens	246-255
32912211-6	2020	Further, Tax and M22 protein expression were strongly enhanced by 12-O-Tetradecanoylphorbol-13-Acetate [TPA; Phorbol 12-myristate 13-acetate (PMA)]/ ionomycin, inducers of NF-kappaB and cytokine signaling, but not by tumor necrosis factor alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	109-140	nuclear factor kappa B subunit 1	Homo sapiens	172-181
32554052-4	2020	Eomes promoted the interaction of RelA and NFATc2 with the Ifng promoter and five CNS, including CNS-22 and CNS + 30 upon stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	139-170	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2	Mus musculus	43-49
32413552-7	2020	As expected for a PKC target site, the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) increases S892 phosphorylation whereas the broad-spectrum PKC inhibitor Go 6983 inhibits both basal and TPA-induced S892 phosphorylation.	Tetradecanoylphorbol Acetate	53-89	proline rich transmembrane protein 2	Homo sapiens	18-21
32413552-7	2020	As expected for a PKC target site, the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) increases S892 phosphorylation whereas the broad-spectrum PKC inhibitor Go 6983 inhibits both basal and TPA-induced S892 phosphorylation.	Tetradecanoylphorbol Acetate	53-89	proline rich transmembrane protein 2	Homo sapiens	39-42
32413552-7	2020	As expected for a PKC target site, the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) increases S892 phosphorylation whereas the broad-spectrum PKC inhibitor Go 6983 inhibits both basal and TPA-induced S892 phosphorylation.	Tetradecanoylphorbol Acetate	53-89	proline rich transmembrane protein 2	Homo sapiens	39-42
32413552-7	2020	As expected for a PKC target site, the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) increases S892 phosphorylation whereas the broad-spectrum PKC inhibitor Go 6983 inhibits both basal and TPA-induced S892 phosphorylation.	Tetradecanoylphorbol Acetate	91-94	proline rich transmembrane protein 2	Homo sapiens	18-21
32413552-7	2020	As expected for a PKC target site, the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) increases S892 phosphorylation whereas the broad-spectrum PKC inhibitor Go 6983 inhibits both basal and TPA-induced S892 phosphorylation.	Tetradecanoylphorbol Acetate	91-94	proline rich transmembrane protein 2	Homo sapiens	39-42
32413552-7	2020	As expected for a PKC target site, the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) increases S892 phosphorylation whereas the broad-spectrum PKC inhibitor Go 6983 inhibits both basal and TPA-induced S892 phosphorylation.	Tetradecanoylphorbol Acetate	91-94	proline rich transmembrane protein 2	Homo sapiens	39-42
32413552-7	2020	As expected for a PKC target site, the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) increases S892 phosphorylation whereas the broad-spectrum PKC inhibitor Go 6983 inhibits both basal and TPA-induced S892 phosphorylation.	Tetradecanoylphorbol Acetate	200-203	proline rich transmembrane protein 2	Homo sapiens	18-21
32413552-7	2020	As expected for a PKC target site, the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) increases S892 phosphorylation whereas the broad-spectrum PKC inhibitor Go 6983 inhibits both basal and TPA-induced S892 phosphorylation.	Tetradecanoylphorbol Acetate	200-203	proline rich transmembrane protein 2	Homo sapiens	39-42
32413552-7	2020	As expected for a PKC target site, the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) increases S892 phosphorylation whereas the broad-spectrum PKC inhibitor Go 6983 inhibits both basal and TPA-induced S892 phosphorylation.	Tetradecanoylphorbol Acetate	200-203	proline rich transmembrane protein 2	Homo sapiens	39-42
33084597-5	2020	In this study, human monocyte, THP-1 was induced to macrophages by using phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	73-104	GLI family zinc finger 2	Homo sapiens	31-36
33084597-5	2020	In this study, human monocyte, THP-1 was induced to macrophages by using phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	106-109	GLI family zinc finger 2	Homo sapiens	31-36
32554052-4	2020	Eomes promoted the interaction of RelA and NFATc2 with the Ifng promoter and five CNS, including CNS-22 and CNS + 30 upon stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	172-175	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2	Mus musculus	43-49
32578964-9	2020	Patients segregated a priori into three groups, where group 1 displayed stable clinical symptoms and/or slower magnetic resonance imaging radiological progression, expanded CD4+ effector T-cells that attenuated cytotoxic T-lymphocyte associated protein-4 and PD-1 expression and secreted interferon gamma and tumor necrosis factor alpha in situ and ex vivo upon stimulation with PMA/ionomycin.	Tetradecanoylphorbol Acetate	379-382	CD4 molecule	Homo sapiens	173-176
32673443-7	2020	We collected the conditioned medium from lipopolysaccharide-activated phorbol myristate acetate-induced THP1 (M1) cells to stimulate A549 and H1299 cells and observed that THP1-M1 upregulated SOD-2 by secreting TNF-alpha.	Tetradecanoylphorbol Acetate	70-95	GLI family zinc finger 2	Homo sapiens	104-108
32441363-6	2020	In THP-1 cells, BR inhibited phorbol myristate acetate-induced monocyte-to-macrophage differentiation by suppressing cluster of differentiation molecule beta and CD36.	Tetradecanoylphorbol Acetate	29-54	GLI family zinc finger 2	Homo sapiens	3-8
32441363-2	2020	METHODS: Inflammatory responses from RAW264.7 cells and THP-1 were stimulated by lipopolysaccharide (1 microg/ml), and monocyte-to-macrophage differentiation of THP-1 was induced by phorbol myristate acetate (50 ng/ml).	Tetradecanoylphorbol Acetate	182-207	GLI family zinc finger 2	Homo sapiens	56-61
32441363-2	2020	METHODS: Inflammatory responses from RAW264.7 cells and THP-1 were stimulated by lipopolysaccharide (1 microg/ml), and monocyte-to-macrophage differentiation of THP-1 was induced by phorbol myristate acetate (50 ng/ml).	Tetradecanoylphorbol Acetate	182-207	GLI family zinc finger 2	Homo sapiens	161-166
32673443-7	2020	We collected the conditioned medium from lipopolysaccharide-activated phorbol myristate acetate-induced THP1 (M1) cells to stimulate A549 and H1299 cells and observed that THP1-M1 upregulated SOD-2 by secreting TNF-alpha.	Tetradecanoylphorbol Acetate	70-95	GLI family zinc finger 2	Homo sapiens	172-176
32673443-7	2020	We collected the conditioned medium from lipopolysaccharide-activated phorbol myristate acetate-induced THP1 (M1) cells to stimulate A549 and H1299 cells and observed that THP1-M1 upregulated SOD-2 by secreting TNF-alpha.	Tetradecanoylphorbol Acetate	70-95	tumor necrosis factor	Homo sapiens	211-220
32442674-5	2020	Phorbol myrastil acetate (PMA) was chosen as the activator of PKC.	Tetradecanoylphorbol Acetate	26-29	proline rich transmembrane protein 2	Homo sapiens	62-65
32705219-8	2020	Moreover, by using western blot analysis, we determined that EA increased the protein expression of the p53 target proteins p21, p53 upregulated modulator of apoptosis (PUMA) [also known as Bcl-2-binding component 3 (BBC3)] and Phorbol-12-myristate-13-acetate-induced protein 1 (NOXA).	Tetradecanoylphorbol Acetate	228-259	tumor protein p53	Homo sapiens	104-107
32705219-8	2020	Moreover, by using western blot analysis, we determined that EA increased the protein expression of the p53 target proteins p21, p53 upregulated modulator of apoptosis (PUMA) [also known as Bcl-2-binding component 3 (BBC3)] and Phorbol-12-myristate-13-acetate-induced protein 1 (NOXA).	Tetradecanoylphorbol Acetate	228-259	tumor protein p53	Homo sapiens	129-132
32819103-1	2020	Phorbol myristate acetate (PMA)-differentiated THP-1 cells are routinely used in lieu of primary macrophages to study macrophage polarization during host-pathogen interactions and disease progression.	Tetradecanoylphorbol Acetate	0-25	GLI family zinc finger 2	Homo sapiens	47-52
32736685-9	2020	In conclusion, the deletion of Prx I triggered the DMBA/TPA-induced skin tumor formation in vivo and in vitro by regulating the reactive oxygen species (ROS)-p38 mitogen-activated protein kinase (MAPK) pathway.	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase 14	Homo sapiens	158-194
32819103-1	2020	Phorbol myristate acetate (PMA)-differentiated THP-1 cells are routinely used in lieu of primary macrophages to study macrophage polarization during host-pathogen interactions and disease progression.	Tetradecanoylphorbol Acetate	27-30	GLI family zinc finger 2	Homo sapiens	47-52
32819103-2	2020	The phenotypes of THP-1 macrophages are influenced by the level and duration of PMA stimulation and possibly also by the presence of adhesion factors.	Tetradecanoylphorbol Acetate	80-83	GLI family zinc finger 2	Homo sapiens	18-23
32792604-6	2020	Human THP-1 monocytes were activated with phorbol-12-myristate-13-acetate (PMA) and differentiated into M1 macrophages with IFNgamma or M2 macrophages with IL4.	Tetradecanoylphorbol Acetate	42-73	GLI family zinc finger 2	Homo sapiens	6-11
32792604-6	2020	Human THP-1 monocytes were activated with phorbol-12-myristate-13-acetate (PMA) and differentiated into M1 macrophages with IFNgamma or M2 macrophages with IL4.	Tetradecanoylphorbol Acetate	75-78	GLI family zinc finger 2	Homo sapiens	6-11
32267089-5	2020	The IFN-gamma secreting cells were detected in mice BALF by stimulation with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	77-102	interferon gamma	Mus musculus	4-13
32865666-8	2020	Tau-Cl inhibited the PMA-induced degranulation of MPO and formation of NETs.	Tetradecanoylphorbol Acetate	21-24	myeloperoxidase	Homo sapiens	50-53
32679895-9	2020	In the in vivo animal model, EARDP significantly and dose-dependently reduced TPA-induced secretion of TNF-alpha and IL-6 in mouse ear.	Tetradecanoylphorbol Acetate	78-81	tumor necrosis factor	Mus musculus	103-112
32504994-9	2020	In phorbol myristate acetate (PMA)-stimulated A549 or H292 airway epithelial cells, pretreatment of THCA dose-dependently inhibited the generation of IL-6.	Tetradecanoylphorbol Acetate	3-28	interleukin 6	Homo sapiens	150-154
32504994-9	2020	In phorbol myristate acetate (PMA)-stimulated A549 or H292 airway epithelial cells, pretreatment of THCA dose-dependently inhibited the generation of IL-6.	Tetradecanoylphorbol Acetate	30-33	interleukin 6	Homo sapiens	150-154
32339486-0	2020	Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene.	Tetradecanoylphorbol Acetate	64-101	G protein-coupled receptor class C group 5 member A	Homo sapiens	45-51
32339486-0	2020	Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene.	Tetradecanoylphorbol Acetate	64-101	G protein-coupled receptor class C group 5 member A	Homo sapiens	52-58
32339486-0	2020	Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene.	Tetradecanoylphorbol Acetate	103-106	G protein-coupled receptor class C group 5 member A	Homo sapiens	45-51
32339486-0	2020	Identification and characterization of human PEIG-1/GPRC5A as a 12-O-tetradecanoyl phorbol-13-acetate (TPA) and PKC-induced gene.	Tetradecanoylphorbol Acetate	103-106	G protein-coupled receptor class C group 5 member A	Homo sapiens	52-58
32339486-1	2020	Homo sapiens orphan G protein-coupling receptor PEIG-1 was first cloned and characterized by applying differential display to T84 colonic carcinoma cells incubated in the presence of phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (GenBank AF506289.1).	Tetradecanoylphorbol Acetate	197-233	G protein-coupled receptor class C group 5 member A	Homo sapiens	48-54
32339486-1	2020	Homo sapiens orphan G protein-coupling receptor PEIG-1 was first cloned and characterized by applying differential display to T84 colonic carcinoma cells incubated in the presence of phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (GenBank AF506289.1).	Tetradecanoylphorbol Acetate	235-238	G protein-coupled receptor class C group 5 member A	Homo sapiens	48-54
32339486-5	2020	In addition, we show that TPA (100 ng/ml, 162 nM) strongly stimulated GPRC5A mRNA in T84 colonic carcinoma cells, with maximal expression at 4 h and 100 ng/ml (162 nM).	Tetradecanoylphorbol Acetate	26-29	G protein-coupled receptor class C group 5 member A	Homo sapiens	70-76
32339486-12	2020	In conclusion, RAIG1/RAI3/GPRC5A corresponds to the originally reported PEIG-1/TIG1; the inhibition observed in the presence of Go 6983, BAPTA and U0126, suggests that its TPA-induced upregulation is mediated through a PKC/Ca2+  MEK1/2 signalling axis.	Tetradecanoylphorbol Acetate	172-175	G protein-coupled receptor class C group 5 member A	Homo sapiens	15-20
32339486-12	2020	In conclusion, RAIG1/RAI3/GPRC5A corresponds to the originally reported PEIG-1/TIG1; the inhibition observed in the presence of Go 6983, BAPTA and U0126, suggests that its TPA-induced upregulation is mediated through a PKC/Ca2+  MEK1/2 signalling axis.	Tetradecanoylphorbol Acetate	172-175	G protein-coupled receptor class C group 5 member A	Homo sapiens	21-25
32339486-12	2020	In conclusion, RAIG1/RAI3/GPRC5A corresponds to the originally reported PEIG-1/TIG1; the inhibition observed in the presence of Go 6983, BAPTA and U0126, suggests that its TPA-induced upregulation is mediated through a PKC/Ca2+  MEK1/2 signalling axis.	Tetradecanoylphorbol Acetate	172-175	G protein-coupled receptor class C group 5 member A	Homo sapiens	26-32
32339486-12	2020	In conclusion, RAIG1/RAI3/GPRC5A corresponds to the originally reported PEIG-1/TIG1; the inhibition observed in the presence of Go 6983, BAPTA and U0126, suggests that its TPA-induced upregulation is mediated through a PKC/Ca2+  MEK1/2 signalling axis.	Tetradecanoylphorbol Acetate	172-175	G protein-coupled receptor class C group 5 member A	Homo sapiens	72-78
32339486-12	2020	In conclusion, RAIG1/RAI3/GPRC5A corresponds to the originally reported PEIG-1/TIG1; the inhibition observed in the presence of Go 6983, BAPTA and U0126, suggests that its TPA-induced upregulation is mediated through a PKC/Ca2+  MEK1/2 signalling axis.	Tetradecanoylphorbol Acetate	172-175	G protein-coupled receptor class C group 5 member A	Homo sapiens	79-83
32679895-9	2020	In the in vivo animal model, EARDP significantly and dose-dependently reduced TPA-induced secretion of TNF-alpha and IL-6 in mouse ear.	Tetradecanoylphorbol Acetate	78-81	interleukin 6	Mus musculus	117-121
32095918-5	2020	PMA mediated activation of both PKC and ERK and either inhibition of PKC by Go6983 or ERK by the MEK inhibitor Trametinib attenuated both P-ERK and P-PKC in both cardiac fibroblasts isolated from AF rats or from healthy rats but transduced with PKC-delta.	Tetradecanoylphorbol Acetate	0-3	Eph receptor B1	Rattus norvegicus	40-43
32719792-2	2020	Here we have employed Cap Analysis of Gene Expression (CAGE) to analyze a dense time course of transcriptional regulation in THP-1 cells treated with phorbol myristate acetate (PMA) over 96 h. PMA treatment greatly reduced the numbers of cells entering S phase and also blocked cells exiting G2/M.	Tetradecanoylphorbol Acetate	150-175	GLI family zinc finger 2	Homo sapiens	125-130
32719792-2	2020	Here we have employed Cap Analysis of Gene Expression (CAGE) to analyze a dense time course of transcriptional regulation in THP-1 cells treated with phorbol myristate acetate (PMA) over 96 h. PMA treatment greatly reduced the numbers of cells entering S phase and also blocked cells exiting G2/M.	Tetradecanoylphorbol Acetate	177-180	GLI family zinc finger 2	Homo sapiens	125-130
32719792-2	2020	Here we have employed Cap Analysis of Gene Expression (CAGE) to analyze a dense time course of transcriptional regulation in THP-1 cells treated with phorbol myristate acetate (PMA) over 96 h. PMA treatment greatly reduced the numbers of cells entering S phase and also blocked cells exiting G2/M.	Tetradecanoylphorbol Acetate	193-196	GLI family zinc finger 2	Homo sapiens	125-130
31529243-6	2020	Topical DMBA and TPA application resulted in a significant increase in the protein levels, immunoreactivity, and mRNA expression of HRAS, HIF1alpha, Akt, and PTEN (p &lt; 0.05).	Tetradecanoylphorbol Acetate	17-20	thymoma viral proto-oncogene 1	Mus musculus	149-152
31529243-6	2020	Topical DMBA and TPA application resulted in a significant increase in the protein levels, immunoreactivity, and mRNA expression of HRAS, HIF1alpha, Akt, and PTEN (p &lt; 0.05).	Tetradecanoylphorbol Acetate	17-20	phosphatase and tensin homolog	Mus musculus	158-162
32626908-7	2020	Microglia in the group receiving 72 h of PMA stimulation displayed the highest percentage of cells arrested in G0/G1, the highest amount of senescence-associated expression of p53 and p21, and the most prominent secretion of TNF-alpha and IL-1beta.	Tetradecanoylphorbol Acetate	41-44	tumor necrosis factor	Rattus norvegicus	225-234
32189398-5	2020	In GC patients, iNKT cells, expanded in vitro with alpha-Galactosyl Ceramide and stimulated with PMA and Ionomycin, produced higher levels of IL-2 and TGF-beta, while their capacity to degranulate remained preserved.	Tetradecanoylphorbol Acetate	97-100	interleukin 2	Homo sapiens	142-146
32859885-3	2020	PKC activator phorbol 12-myristate 13-acetate induced the Akt phosphorylation in rat primary GCs but reduced the Akt phosphorylation in KGN human GCs.	Tetradecanoylphorbol Acetate	14-45	AKT serine/threonine kinase 1	Rattus norvegicus	58-61
32859885-3	2020	PKC activator phorbol 12-myristate 13-acetate induced the Akt phosphorylation in rat primary GCs but reduced the Akt phosphorylation in KGN human GCs.	Tetradecanoylphorbol Acetate	14-45	AKT serine/threonine kinase 1	Rattus norvegicus	113-116
32447451-5	2020	RESULTS: Stimulation of cells by PMA or LPS (without Actovegin ) significantly increased the secretion of IL-1beta, IL-6, IL-10 and TNF-alpha from PBMCs, compared to controls.	Tetradecanoylphorbol Acetate	33-36	interleukin 6	Homo sapiens	116-120
32447451-5	2020	RESULTS: Stimulation of cells by PMA or LPS (without Actovegin ) significantly increased the secretion of IL-1beta, IL-6, IL-10 and TNF-alpha from PBMCs, compared to controls.	Tetradecanoylphorbol Acetate	33-36	tumor necrosis factor	Homo sapiens	132-141
32626908-7	2020	Microglia in the group receiving 72 h of PMA stimulation displayed the highest percentage of cells arrested in G0/G1, the highest amount of senescence-associated expression of p53 and p21, and the most prominent secretion of TNF-alpha and IL-1beta.	Tetradecanoylphorbol Acetate	41-44	interleukin 1 alpha	Rattus norvegicus	239-247
32521784-0	2020	Glycogen Synthase Kinase-3beta Facilitates Cytokine Production in 12-O-Tetradecanoylphorbol-13-Acetate/Ionomycin-Activated Human CD4+ T Lymphocytes.	Tetradecanoylphorbol Acetate	66-102	CD4 molecule	Homo sapiens	129-132
32580281-5	2020	We explored PKC-dependent regulation of TRPM8 using Phorbol 12-Myristate 13-Acetate to activate this kinase.	Tetradecanoylphorbol Acetate	52-83	proline rich transmembrane protein 2	Homo sapiens	12-15
32512874-4	2020	The expression of tumor necrosis factor-a (TNF-a) and inducible nitric oxide synthase (iNOS) was also suppressed by scytonemin treatment in the TPA-treated ear of BALB/c mice.	Tetradecanoylphorbol Acetate	144-147	tumor necrosis factor	Mus musculus	18-41
32512874-4	2020	The expression of tumor necrosis factor-a (TNF-a) and inducible nitric oxide synthase (iNOS) was also suppressed by scytonemin treatment in the TPA-treated ear of BALB/c mice.	Tetradecanoylphorbol Acetate	144-147	tumor necrosis factor	Mus musculus	43-48
32512874-4	2020	The expression of tumor necrosis factor-a (TNF-a) and inducible nitric oxide synthase (iNOS) was also suppressed by scytonemin treatment in the TPA-treated ear of BALB/c mice.	Tetradecanoylphorbol Acetate	144-147	nitric oxide synthase 2, inducible	Mus musculus	54-85
32512874-4	2020	The expression of tumor necrosis factor-a (TNF-a) and inducible nitric oxide synthase (iNOS) was also suppressed by scytonemin treatment in the TPA-treated ear of BALB/c mice.	Tetradecanoylphorbol Acetate	144-147	nitric oxide synthase 2, inducible	Mus musculus	87-91
32521784-3	2020	The artificial in vitro activation of CD4+ T lymphocytes by a combination of 12-O-tetradecanoylphorbol-13-acetate and ionomycin, the so-called T/I model, led to an inducible production of cytokines, such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-2.	Tetradecanoylphorbol Acetate	77-113	CD4 molecule	Homo sapiens	38-41
32521784-3	2020	The artificial in vitro activation of CD4+ T lymphocytes by a combination of 12-O-tetradecanoylphorbol-13-acetate and ionomycin, the so-called T/I model, led to an inducible production of cytokines, such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-2.	Tetradecanoylphorbol Acetate	77-113	interferon gamma	Homo sapiens	207-223
32521784-3	2020	The artificial in vitro activation of CD4+ T lymphocytes by a combination of 12-O-tetradecanoylphorbol-13-acetate and ionomycin, the so-called T/I model, led to an inducible production of cytokines, such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-2.	Tetradecanoylphorbol Acetate	77-113	tumor necrosis factor	Homo sapiens	225-252
32521784-3	2020	The artificial in vitro activation of CD4+ T lymphocytes by a combination of 12-O-tetradecanoylphorbol-13-acetate and ionomycin, the so-called T/I model, led to an inducible production of cytokines, such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-2.	Tetradecanoylphorbol Acetate	77-113	interleukin 2	Homo sapiens	258-271
32037602-8	2020	Incubation with the ERK activator, phorbol 12-myristate 13-acetate (40 mumol/L), for 12 hours reversed the effects of HOXB5 inhibition on MDM2 expression, cell proliferation, and apoptosis in HCC cells.	Tetradecanoylphorbol Acetate	35-66	mitogen-activated protein kinase 1	Mus musculus	20-23
32052678-2	2020	However, we found that exposure to GSM-modulated 1800 MHz signals at 2 W/kg decreased the PMA maximal efficacy to activate both RAS and ERK kinases" activity.	Tetradecanoylphorbol Acetate	90-93	mitogen-activated protein kinase 1	Homo sapiens	136-139
32052678-3	2020	Exposure with CW 1800 MHz signal at 2 W/kg only decreased maximal efficacy of PMA to activate ERK but not RAS.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 1	Homo sapiens	94-97
32404145-6	2020	Mutation of IL4I1 in chicken HD11 macrophages did not affect their bactericidal capacity against S. Enteritidis but negatively affected their oxidative burst after PMA stimulation.	Tetradecanoylphorbol Acetate	164-167	interleukin 4 induced 1	Gallus gallus	12-17
32596498-7	2020	Results: PMA exposure induced DNA, MPO, and CitH3 by immunofluorescence (IF) most significantly at 3 hours (3.8-fold for DAPI, 7.6-fold for MPO, and 6.9-fold for CitH3, all P < .05).	Tetradecanoylphorbol Acetate	9-12	myeloperoxidase	Homo sapiens	35-38
32596498-7	2020	Results: PMA exposure induced DNA, MPO, and CitH3 by immunofluorescence (IF) most significantly at 3 hours (3.8-fold for DAPI, 7.6-fold for MPO, and 6.9-fold for CitH3, all P < .05).	Tetradecanoylphorbol Acetate	9-12	myeloperoxidase	Homo sapiens	140-143
31637713-4	2020	Tight junction scaffold proteins ZO-1 and ZO-2 localize at podosomes in response to phorbol-12-myristate-13-acetate treatment.	Tetradecanoylphorbol Acetate	84-115	tight junction protein 1	Homo sapiens	33-46
31893611-8	2020	Taken together, our findings indicated that ML attenuated the TPA-stimulated invasion and migration of MCF-7 cells by suppressing the phosphorylation of ERK and its downstream factors, AP-1 and STAT3.	Tetradecanoylphorbol Acetate	62-65	mitogen-activated protein kinase 1	Homo sapiens	153-156
32171817-6	2020	Activating PKCalpha with phorbol 12-myristate 13-acetate (PMA), a phorbol ester binds and activates PKCalpha) promoted SCs proliferation and migration.	Tetradecanoylphorbol Acetate	25-56	protein kinase C alpha	Homo sapiens	11-19
32171817-6	2020	Activating PKCalpha with phorbol 12-myristate 13-acetate (PMA), a phorbol ester binds and activates PKCalpha) promoted SCs proliferation and migration.	Tetradecanoylphorbol Acetate	25-56	protein kinase C alpha	Homo sapiens	100-108
32171817-6	2020	Activating PKCalpha with phorbol 12-myristate 13-acetate (PMA), a phorbol ester binds and activates PKCalpha) promoted SCs proliferation and migration.	Tetradecanoylphorbol Acetate	58-61	protein kinase C alpha	Homo sapiens	11-19
32171817-6	2020	Activating PKCalpha with phorbol 12-myristate 13-acetate (PMA), a phorbol ester binds and activates PKCalpha) promoted SCs proliferation and migration.	Tetradecanoylphorbol Acetate	58-61	protein kinase C alpha	Homo sapiens	100-108
31490714-2	2020	The goal of our study was to evaluate the association between presentation by EMS and EMS prenotification with odds of receiving Tissue-type Plasminogen Activator (IV-tPA) in a state implementing SSoC while rigorously accounting for missing data.	Tetradecanoylphorbol Acetate	167-170	plasminogen activator, tissue type	Homo sapiens	129-162
32373641-8	2020	After 12 h, PMA-induced ROS production decreased, which was sustained until 48 h. The expressions of inflammation markers (IL1alpha, IL1beta, IL6, IL10, TNFalpha, STAT3, TLR4, MMP9, and HP) and eicosanoids (ALOX5, ALOX5AP, and PLA2G4A) were upregulated.	Tetradecanoylphorbol Acetate	12-15	arachidonate 5-lipoxygenase	Bos taurus	207-212
32373641-8	2020	After 12 h, PMA-induced ROS production decreased, which was sustained until 48 h. The expressions of inflammation markers (IL1alpha, IL1beta, IL6, IL10, TNFalpha, STAT3, TLR4, MMP9, and HP) and eicosanoids (ALOX5, ALOX5AP, and PLA2G4A) were upregulated.	Tetradecanoylphorbol Acetate	12-15	arachidonate 5-lipoxygenase activating protein	Bos taurus	214-221
32070494-10	2020	For THP-1 cells, PMA could induce CD10 expression through the MAPK pathway.	Tetradecanoylphorbol Acetate	17-20	membrane metalloendopeptidase	Homo sapiens	34-38
32289862-0	2020	Heparanase Facilitates PMA-Induced Megakaryocytic Differentiation in K562 Cells via Interleukin 6/STAT3 Pathway.	Tetradecanoylphorbol Acetate	23-26	heparanase	Homo sapiens	0-10
32289862-0	2020	Heparanase Facilitates PMA-Induced Megakaryocytic Differentiation in K562 Cells via Interleukin 6/STAT3 Pathway.	Tetradecanoylphorbol Acetate	23-26	interleukin 6	Homo sapiens	84-97
32289862-0	2020	Heparanase Facilitates PMA-Induced Megakaryocytic Differentiation in K562 Cells via Interleukin 6/STAT3 Pathway.	Tetradecanoylphorbol Acetate	23-26	signal transducer and activator of transcription 3	Homo sapiens	98-103
32223128-3	2020	Briefly, mesoporous silica materials (MSN) loaded with doxorubicin (DOX) and phorbol 12-myristate 13-acetate (PMA) was used as drug carrier and could be specifically opened by nucleolin in HeLa cell.	Tetradecanoylphorbol Acetate	77-108	moesin	Homo sapiens	38-41
32223128-3	2020	Briefly, mesoporous silica materials (MSN) loaded with doxorubicin (DOX) and phorbol 12-myristate 13-acetate (PMA) was used as drug carrier and could be specifically opened by nucleolin in HeLa cell.	Tetradecanoylphorbol Acetate	110-113	moesin	Homo sapiens	38-41
32425545-8	2020	Results: Human Thp-1 monocytes were successfully polarized into M2-like TAMs using PMA, IL-6, and IL-4.	Tetradecanoylphorbol Acetate	83-86	GLI family zinc finger 2	Homo sapiens	15-20
32290690-0	2021	Bamboo leave extract ameliorated 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ear inflammation by reducing MAP kinase levels and NF-kappaB activation in mice model.	Tetradecanoylphorbol Acetate	33-69	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-144
32290690-0	2021	Bamboo leave extract ameliorated 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ear inflammation by reducing MAP kinase levels and NF-kappaB activation in mice model.	Tetradecanoylphorbol Acetate	71-74	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-144
32290690-8	2021	Further, SCN treatment significantly antagonized the protein expression of MAP kinase signaling pathway and reduced the effect of TPA-induced NF-kappaB activation, sequentially, deactivated its transcriptional targets in a dose-dependent manner.	Tetradecanoylphorbol Acetate	130-133	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
34012866-10	2021	Administration of AAILE to DMBA/TPA treated animals caused a decrease in collagen and GAG levels along with a decrease in serum CEA levels.	Tetradecanoylphorbol Acetate	32-35	carcinoembryonic antigen gene family	Mus musculus	128-131
31893611-0	2020	Methyl linderone suppresses TPA-stimulated IL-8 and MMP-9 expression via the ERK/STAT3 pathway in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
31893611-0	2020	Methyl linderone suppresses TPA-stimulated IL-8 and MMP-9 expression via the ERK/STAT3 pathway in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 1	Homo sapiens	77-80
31893611-8	2020	Taken together, our findings indicated that ML attenuated the TPA-stimulated invasion and migration of MCF-7 cells by suppressing the phosphorylation of ERK and its downstream factors, AP-1 and STAT3.	Tetradecanoylphorbol Acetate	62-65	signal transducer and activator of transcription 3	Homo sapiens	194-199
31893611-0	2020	Methyl linderone suppresses TPA-stimulated IL-8 and MMP-9 expression via the ERK/STAT3 pathway in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	28-31	signal transducer and activator of transcription 3	Homo sapiens	81-86
31893611-6	2020	Moreover, it inhibited two metastasis-related factors, matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8), at the mRNA and protein expression levels, in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	94-107
31893611-6	2020	Moreover, it inhibited two metastasis-related factors, matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8), at the mRNA and protein expression levels, in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
32300280-7	2020	Combination of Vincristine with TPA/GSK126, a drug combination shown to induce differentiation of RMS cell lines, is able to partially overcome MYOD1/NOG cells chemoresistance.	Tetradecanoylphorbol Acetate	32-35	myogenic differentiation 1	Homo sapiens	144-149
32179476-5	2020	Significantly, activation of PKCalpha with other activating or inflammatory agents, including phorbol 12-myristate 13-acetate and histamine, modulates Golgi structure in a similar fashion.	Tetradecanoylphorbol Acetate	94-125	protein kinase C alpha	Homo sapiens	29-37
32148409-10	2020	Western blot analysis showed that TPA enhanced the phosphorylation of PKCdelta and ERK in the keratinocytes.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 1	Mus musculus	83-86
31973815-4	2020	Phorbol myristate acetate (PMA), a tumor promoter, also induces production of superoxides; PMA activates Src, a tyrosine kinase, and increases p-Tyr42 RhoA levels.	Tetradecanoylphorbol Acetate	0-25	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-108
31973815-4	2020	Phorbol myristate acetate (PMA), a tumor promoter, also induces production of superoxides; PMA activates Src, a tyrosine kinase, and increases p-Tyr42 RhoA levels.	Tetradecanoylphorbol Acetate	0-25	ras homolog family member A	Homo sapiens	151-155
31973815-4	2020	Phorbol myristate acetate (PMA), a tumor promoter, also induces production of superoxides; PMA activates Src, a tyrosine kinase, and increases p-Tyr42 RhoA levels.	Tetradecanoylphorbol Acetate	27-30	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-108
31973815-4	2020	Phorbol myristate acetate (PMA), a tumor promoter, also induces production of superoxides; PMA activates Src, a tyrosine kinase, and increases p-Tyr42 RhoA levels.	Tetradecanoylphorbol Acetate	27-30	ras homolog family member A	Homo sapiens	151-155
31973815-4	2020	Phorbol myristate acetate (PMA), a tumor promoter, also induces production of superoxides; PMA activates Src, a tyrosine kinase, and increases p-Tyr42 RhoA levels.	Tetradecanoylphorbol Acetate	91-94	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-108
31973815-4	2020	Phorbol myristate acetate (PMA), a tumor promoter, also induces production of superoxides; PMA activates Src, a tyrosine kinase, and increases p-Tyr42 RhoA levels.	Tetradecanoylphorbol Acetate	91-94	ras homolog family member A	Homo sapiens	151-155
31973815-5	2020	In exploring the mechanism of PMA effects, we reduced RhoA levels in test cells with si-RhoA and then restoration of various versions of RhoA for effect in response of the cells to PMA and producing superoxides.	Tetradecanoylphorbol Acetate	30-33	ras homolog family member A	Homo sapiens	54-58
31973815-6	2020	Restoration of RhoA Y42F (a dephospho-mimic form) still had reduced superoxide formation in response to PMA, compared with WT and Y42E RhoA.	Tetradecanoylphorbol Acetate	104-107	ras homolog family member A	Homo sapiens	15-19
31973815-10	2020	Overall, we demonstrate that p-Tyr42 RhoA levels increase following PMA treatment and this is through production of superoxide and activation of Src.	Tetradecanoylphorbol Acetate	68-71	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	145-148
32148409-11	2020	When we examined the effect of ginsenoside Rh3, we identified that ginsenoside Rh3 inhibited the TPA-induced phosphorylation levels of PKCdelta and ERK.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 1	Mus musculus	148-151
32049985-9	2020	Notably, a similar effect was observed when NF-kappaB activation was triggered independently of ligand-receptor specificity, using phorbol-myristate-acetate (PMA).	Tetradecanoylphorbol Acetate	131-156	nuclear factor kappa B subunit 1	Homo sapiens	44-53
32132496-1	2020	INTRODUCTION: Intravenous thrombolytic therapy with recombinant tissue type plasminogen activator (IV-tPA) is the first-line treatment option for acute ischemic stroke (AIS).	Tetradecanoylphorbol Acetate	102-105	plasminogen activator, tissue type	Homo sapiens	64-97
32049985-9	2020	Notably, a similar effect was observed when NF-kappaB activation was triggered independently of ligand-receptor specificity, using phorbol-myristate-acetate (PMA).	Tetradecanoylphorbol Acetate	158-161	nuclear factor kappa B subunit 1	Homo sapiens	44-53
31939617-0	2020	Inhibition of TPA-induced metastatic potential by morin hydrate in MCF-7 human breast cancer cells via the Akt/GSK-3beta/c-Fos signaling pathway.	Tetradecanoylphorbol Acetate	14-17	AKT serine/threonine kinase 1	Homo sapiens	107-110
32074974-5	2020	Cell migration and invasion assays with human glioblastoma cells were performed to investigate the anti-invasive effect of CTR-GNPs on U87 cells that were treated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	168-199	calcitonin receptor	Homo sapiens	123-126
32074974-6	2020	The results show that CTR-GNPs can significantly inhibit both basal and phorbol 12-myristate 13-acetate (PMA)-induced migration and invasion ability.	Tetradecanoylphorbol Acetate	72-103	calcitonin receptor	Homo sapiens	22-25
32074974-6	2020	The results show that CTR-GNPs can significantly inhibit both basal and phorbol 12-myristate 13-acetate (PMA)-induced migration and invasion ability.	Tetradecanoylphorbol Acetate	105-108	calcitonin receptor	Homo sapiens	22-25
32074974-8	2020	These results present a novel mechanism showing that CTR-GNPs can attenuate the migration and invasion of glioblastoma cells induced by PMA through transcriptional and translational regulation of MMP-2/-9 and PLD1.	Tetradecanoylphorbol Acetate	136-139	calcitonin receptor	Homo sapiens	53-56
32074974-8	2020	These results present a novel mechanism showing that CTR-GNPs can attenuate the migration and invasion of glioblastoma cells induced by PMA through transcriptional and translational regulation of MMP-2/-9 and PLD1.	Tetradecanoylphorbol Acetate	136-139	phospholipase D1	Homo sapiens	209-213
31964467-3	2020	Therefore, we wanted to know whether transduced PEP-1-GLRX1 protein inhibits lipopolysaccharide (LPS)- and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced inflammation.	Tetradecanoylphorbol Acetate	107-144	glutaredoxin	Mus musculus	54-59
31964467-3	2020	Therefore, we wanted to know whether transduced PEP-1-GLRX1 protein inhibits lipopolysaccharide (LPS)- and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced inflammation.	Tetradecanoylphorbol Acetate	146-149	glutaredoxin	Mus musculus	54-59
31964467-5	2020	In a TPA-induced mouse-ear edema model, topically applied PEP-1-GLRX1 transduced into ear tissues and significantly ameliorated ear edema.	Tetradecanoylphorbol Acetate	5-8	glutaredoxin	Mus musculus	64-69
31939617-8	2020	Taken together, these results demonstrated that morin hydrate reduced the metastatic potential in TPA-treated MCF-7 human breast cancer cells via the inhibition of MMPs, uPA and uPAR, and the underlying Akt/GSK-3beta/c-Fos pathway.	Tetradecanoylphorbol Acetate	98-101	AKT serine/threonine kinase 1	Homo sapiens	203-206
31939617-8	2020	Taken together, these results demonstrated that morin hydrate reduced the metastatic potential in TPA-treated MCF-7 human breast cancer cells via the inhibition of MMPs, uPA and uPAR, and the underlying Akt/GSK-3beta/c-Fos pathway.	Tetradecanoylphorbol Acetate	98-101	plasminogen activator, urokinase	Homo sapiens	170-173
31974614-9	2020	Immunofluorescence staining and western blot analysis demonstrated increased CTL1 expression on the cell membrane following PMA treatment.	Tetradecanoylphorbol Acetate	124-127	solute carrier family 44 member 1	Homo sapiens	77-81
31407399-4	2020	Here we report that the action potential (AP) firing activity of ARC neurons in culture was up-regulated by application of the adenylate cyclase activator forskolin or the PKC activator PMA, and that the forskolin or PMA application-induced up-regulation of AP firing activity could be blocked by pre-application of the SFK inhibitor PP2.	Tetradecanoylphorbol Acetate	186-189	protein kinase C alpha	Homo sapiens	172-175
31407399-6	2020	Furthermore, we identified that forskolin or PMA application caused increases in the phosphorylation not only in PKAs at T197 or PKCs at S660 and PKCalpha/betaII at T638/641, but also in SFKs at Y416.	Tetradecanoylphorbol Acetate	45-48	protein kinase C alpha	Homo sapiens	146-154
31813339-8	2020	Importantly, DUSP19 silencing and overexpression mediated p-NF-kappaBp65 level, cleaved Caspase-3 expression, and concentration of IL-6 and IL-8 in mouse primary microglia cells were reversed by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and NF-kappaB activator 12-myristate 13-acetate (PMA), respectively.Conclusion: These results suggested that DUSP19-mediated SCI-induced apoptosis and inflammation via NF-kappaB signaling and might therefore serve as a potential therapeutic target for SCI.	Tetradecanoylphorbol Acetate	299-302	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	195-204
31979064-4	2020	In BC models, the phorbol ester 12-myristate 13-acetate (PMA)-mediated activation of protein kinase C (PKC) induced a down-regulation of CAXII with a concomitant modulation of other members of the transport metabolon, including CAIX and the sodium bicarbonate cotransporter 3 (NBCn1).	Tetradecanoylphorbol Acetate	57-60	proline rich transmembrane protein 2	Homo sapiens	85-101
31979064-4	2020	In BC models, the phorbol ester 12-myristate 13-acetate (PMA)-mediated activation of protein kinase C (PKC) induced a down-regulation of CAXII with a concomitant modulation of other members of the transport metabolon, including CAIX and the sodium bicarbonate cotransporter 3 (NBCn1).	Tetradecanoylphorbol Acetate	57-60	proline rich transmembrane protein 2	Homo sapiens	103-106
32010831-5	2020	Herein, the expression of membrane-bound TNFalpha was induced by challenging phorbol 12-myristate 13-acetate-differentiated THP-1 cells with bacterial lipopolysaccharide.	Tetradecanoylphorbol Acetate	77-108	tumor necrosis factor	Homo sapiens	41-49
31385383-6	2020	Cytokine production of IFN-gamma and TNF-alpha on CD3- CD56+ NK cells in septic patients was also impaired after stimulation by PMA and ionomycin.	Tetradecanoylphorbol Acetate	128-131	interferon gamma	Homo sapiens	23-32
31385383-6	2020	Cytokine production of IFN-gamma and TNF-alpha on CD3- CD56+ NK cells in septic patients was also impaired after stimulation by PMA and ionomycin.	Tetradecanoylphorbol Acetate	128-131	tumor necrosis factor	Homo sapiens	37-46
30927246-4	2020	THP-1 macrophages differentiated with phorbol 12-myristate 13-acetate (PMA) were incubated in vitro for 48 h with 1 muM or 10 muM sodium orthovanadate (Na3VO4).	Tetradecanoylphorbol Acetate	38-69	GLI family zinc finger 2	Homo sapiens	0-5
30927246-4	2020	THP-1 macrophages differentiated with phorbol 12-myristate 13-acetate (PMA) were incubated in vitro for 48 h with 1 muM or 10 muM sodium orthovanadate (Na3VO4).	Tetradecanoylphorbol Acetate	71-74	GLI family zinc finger 2	Homo sapiens	0-5
31813339-8	2020	Importantly, DUSP19 silencing and overexpression mediated p-NF-kappaBp65 level, cleaved Caspase-3 expression, and concentration of IL-6 and IL-8 in mouse primary microglia cells were reversed by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and NF-kappaB activator 12-myristate 13-acetate (PMA), respectively.Conclusion: These results suggested that DUSP19-mediated SCI-induced apoptosis and inflammation via NF-kappaB signaling and might therefore serve as a potential therapeutic target for SCI.	Tetradecanoylphorbol Acetate	299-302	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	195-204
31722779-6	2019	In a TPA-induced animal model, transduced Tat-CIAPIN1 drastically decreased inflammation damage and inhibited COX-2, iNOS, IL-6, and TNF-alpha expression.	Tetradecanoylphorbol Acetate	5-8	interleukin 6	Mus musculus	123-127
31837261-8	2019	Treatment of T24 cells with orientin inhibited the expression of NF-kappaB and components of the Hedgehog signaling pathway, and the NF-kappaB agonist, PMA, reversed these effects.	Tetradecanoylphorbol Acetate	152-155	nuclear factor kappa B subunit 1	Homo sapiens	133-142
31806018-7	2019	In splenocytes stimulated either with H. meleagridis antigen or PMA/ionomycin, IFN-gamma-producing CD4+ T cells from infected chickens increased in comparison to cells from non-infected birds 2 weeks and 5 weeks post-infection.	Tetradecanoylphorbol Acetate	64-67	T-cell surface glycoprotein CD4	Gallus gallus	99-102
31806018-8	2019	Additionally, an increase of IFN-gamma-producing CD4-CD8beta- cells upon H. meleagridis antigen and PMA/ionomycin stimulation was detected.	Tetradecanoylphorbol Acetate	100-103	T-cell surface glycoprotein CD4	Gallus gallus	49-52
31023186-5	2019	In addition, phorbol ester (phorbol 12-myristate, 13-acetate), previously reported as activating the expression of PGRN, was applied to the system.	Tetradecanoylphorbol Acetate	28-60	granulin precursor	Homo sapiens	115-119
31722779-0	2019	Transduced Tat-CIAPIN1 reduces the inflammatory response on LPS- and TPA-induced damages.	Tetradecanoylphorbol Acetate	69-72	cytokine induced apoptosis inhibitor 1	Mus musculus	15-22
31722779-6	2019	In a TPA-induced animal model, transduced Tat-CIAPIN1 drastically decreased inflammation damage and inhibited COX-2, iNOS, IL-6, and TNF-alpha expression.	Tetradecanoylphorbol Acetate	5-8	cytokine induced apoptosis inhibitor 1	Mus musculus	46-53
31722779-6	2019	In a TPA-induced animal model, transduced Tat-CIAPIN1 drastically decreased inflammation damage and inhibited COX-2, iNOS, IL-6, and TNF-alpha expression.	Tetradecanoylphorbol Acetate	5-8	nitric oxide synthase 2, inducible	Mus musculus	117-121
31722779-6	2019	In a TPA-induced animal model, transduced Tat-CIAPIN1 drastically decreased inflammation damage and inhibited COX-2, iNOS, IL-6, and TNF-alpha expression.	Tetradecanoylphorbol Acetate	5-8	tumor necrosis factor	Mus musculus	133-142
31726940-6	2019	In conclusion, our findings demonstrate mutant p53 may cause chemo-resistance of tumor because of inactivating PUMA transcription, which prompts some new insights for clinical therapy of cancer patients with mutant p53.Abbreviations: CRC: Colorectal cancer; CDKs: Cyclin-dependent kinases; PUMA: p53 up-regulated modulator of apoptosis; PDGF: the platelet-derived growth factor; WT p53: wild-type p53 protein; mutp53: mutant p53 proteins; BAX: Bcl-2-associated X protein; NOXA: Phorbol-12-myristate-13-acetate-induced protein 1.	Tetradecanoylphorbol Acetate	478-509	tumor protein p53	Homo sapiens	47-50
31726940-6	2019	In conclusion, our findings demonstrate mutant p53 may cause chemo-resistance of tumor because of inactivating PUMA transcription, which prompts some new insights for clinical therapy of cancer patients with mutant p53.Abbreviations: CRC: Colorectal cancer; CDKs: Cyclin-dependent kinases; PUMA: p53 up-regulated modulator of apoptosis; PDGF: the platelet-derived growth factor; WT p53: wild-type p53 protein; mutp53: mutant p53 proteins; BAX: Bcl-2-associated X protein; NOXA: Phorbol-12-myristate-13-acetate-induced protein 1.	Tetradecanoylphorbol Acetate	478-509	tumor protein p53	Homo sapiens	215-218
31726940-6	2019	In conclusion, our findings demonstrate mutant p53 may cause chemo-resistance of tumor because of inactivating PUMA transcription, which prompts some new insights for clinical therapy of cancer patients with mutant p53.Abbreviations: CRC: Colorectal cancer; CDKs: Cyclin-dependent kinases; PUMA: p53 up-regulated modulator of apoptosis; PDGF: the platelet-derived growth factor; WT p53: wild-type p53 protein; mutp53: mutant p53 proteins; BAX: Bcl-2-associated X protein; NOXA: Phorbol-12-myristate-13-acetate-induced protein 1.	Tetradecanoylphorbol Acetate	478-509	tumor protein p53	Homo sapiens	215-218
31726940-6	2019	In conclusion, our findings demonstrate mutant p53 may cause chemo-resistance of tumor because of inactivating PUMA transcription, which prompts some new insights for clinical therapy of cancer patients with mutant p53.Abbreviations: CRC: Colorectal cancer; CDKs: Cyclin-dependent kinases; PUMA: p53 up-regulated modulator of apoptosis; PDGF: the platelet-derived growth factor; WT p53: wild-type p53 protein; mutp53: mutant p53 proteins; BAX: Bcl-2-associated X protein; NOXA: Phorbol-12-myristate-13-acetate-induced protein 1.	Tetradecanoylphorbol Acetate	478-509	tumor protein p53	Homo sapiens	215-218
31726940-6	2019	In conclusion, our findings demonstrate mutant p53 may cause chemo-resistance of tumor because of inactivating PUMA transcription, which prompts some new insights for clinical therapy of cancer patients with mutant p53.Abbreviations: CRC: Colorectal cancer; CDKs: Cyclin-dependent kinases; PUMA: p53 up-regulated modulator of apoptosis; PDGF: the platelet-derived growth factor; WT p53: wild-type p53 protein; mutp53: mutant p53 proteins; BAX: Bcl-2-associated X protein; NOXA: Phorbol-12-myristate-13-acetate-induced protein 1.	Tetradecanoylphorbol Acetate	478-509	tumor protein p53	Homo sapiens	215-218
31726940-6	2019	In conclusion, our findings demonstrate mutant p53 may cause chemo-resistance of tumor because of inactivating PUMA transcription, which prompts some new insights for clinical therapy of cancer patients with mutant p53.Abbreviations: CRC: Colorectal cancer; CDKs: Cyclin-dependent kinases; PUMA: p53 up-regulated modulator of apoptosis; PDGF: the platelet-derived growth factor; WT p53: wild-type p53 protein; mutp53: mutant p53 proteins; BAX: Bcl-2-associated X protein; NOXA: Phorbol-12-myristate-13-acetate-induced protein 1.	Tetradecanoylphorbol Acetate	478-509	tumor protein p53	Homo sapiens	215-218
31732450-3	2019	Pretreating T cells for 24 h with BAY 41-2272 at 3 muM and 30 muM, followed by activation with 90 nM phorbol myristate acetate (PMA), inhibited interferon-gamma (IFN-gamma) production, with 3 muM and 30 muM BAY causing 16.5-fold and 12.1-fold inhibition, respectively, compared to PMA alone (p &lt; 0.05, one-way ANOVA followed by Tukey"s test).	Tetradecanoylphorbol Acetate	101-126	interferon gamma	Homo sapiens	162-171
31732450-3	2019	Pretreating T cells for 24 h with BAY 41-2272 at 3 muM and 30 muM, followed by activation with 90 nM phorbol myristate acetate (PMA), inhibited interferon-gamma (IFN-gamma) production, with 3 muM and 30 muM BAY causing 16.5-fold and 12.1-fold inhibition, respectively, compared to PMA alone (p &lt; 0.05, one-way ANOVA followed by Tukey"s test).	Tetradecanoylphorbol Acetate	128-131	interferon gamma	Homo sapiens	144-160
31732450-3	2019	Pretreating T cells for 24 h with BAY 41-2272 at 3 muM and 30 muM, followed by activation with 90 nM phorbol myristate acetate (PMA), inhibited interferon-gamma (IFN-gamma) production, with 3 muM and 30 muM BAY causing 16.5-fold and 12.1-fold inhibition, respectively, compared to PMA alone (p &lt; 0.05, one-way ANOVA followed by Tukey"s test).	Tetradecanoylphorbol Acetate	128-131	interferon gamma	Homo sapiens	162-171
31732450-3	2019	Pretreating T cells for 24 h with BAY 41-2272 at 3 muM and 30 muM, followed by activation with 90 nM phorbol myristate acetate (PMA), inhibited interferon-gamma (IFN-gamma) production, with 3 muM and 30 muM BAY causing 16.5-fold and 12.1-fold inhibition, respectively, compared to PMA alone (p &lt; 0.05, one-way ANOVA followed by Tukey"s test).	Tetradecanoylphorbol Acetate	281-284	interferon gamma	Homo sapiens	162-171
31720442-4	2019	Topical application of DMBA+TPA increased oxidative stress as shown by significantly increased TBARS values and reduced glutathione contents, and glutathione-S-transferase, superoxide dismutase and catalase activities.	Tetradecanoylphorbol Acetate	28-31	catalase	Mus musculus	198-206
31563324-4	2019	Both the expression of the differentiation marker CD14 and activation of the mTOR signaling pathway were induced by 1,25(OH)2D3 in phorbol 12-myristate 13-acetate (PMA)-differentiated U937 and THP-1 cells.	Tetradecanoylphorbol Acetate	131-162	mechanistic target of rapamycin kinase	Homo sapiens	77-81
31563324-4	2019	Both the expression of the differentiation marker CD14 and activation of the mTOR signaling pathway were induced by 1,25(OH)2D3 in phorbol 12-myristate 13-acetate (PMA)-differentiated U937 and THP-1 cells.	Tetradecanoylphorbol Acetate	164-167	mechanistic target of rapamycin kinase	Homo sapiens	77-81
31855322-8	2019	In unstimulated and CCL19-treated CD4+ T cells, expression of the GFP latent reporter, increased after further activation of the cells with PHA/phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	144-175	CD4 molecule	Homo sapiens	34-37
31855322-8	2019	In unstimulated and CCL19-treated CD4+ T cells, expression of the GFP latent reporter, increased after further activation of the cells with PHA/phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	177-180	CD4 molecule	Homo sapiens	34-37
31335245-1	2019	Context: We reported that D-4F, an apolipoprotein A-I (Apo A-I) mimetic polypeptide with 18 d-amino acids, suppressed IL-4 induced macrophage alternative activation and TGF-beta1 expression in phorbol 12-myristate 13-acetate (PMA) treated human acute monocytic leukemia cells (THP-1).	Tetradecanoylphorbol Acetate	193-224	apolipoprotein A1	Homo sapiens	55-62
31335245-1	2019	Context: We reported that D-4F, an apolipoprotein A-I (Apo A-I) mimetic polypeptide with 18 d-amino acids, suppressed IL-4 induced macrophage alternative activation and TGF-beta1 expression in phorbol 12-myristate 13-acetate (PMA) treated human acute monocytic leukemia cells (THP-1).	Tetradecanoylphorbol Acetate	193-224	interleukin 4	Homo sapiens	118-122
31335245-1	2019	Context: We reported that D-4F, an apolipoprotein A-I (Apo A-I) mimetic polypeptide with 18 d-amino acids, suppressed IL-4 induced macrophage alternative activation and TGF-beta1 expression in phorbol 12-myristate 13-acetate (PMA) treated human acute monocytic leukemia cells (THP-1).	Tetradecanoylphorbol Acetate	193-224	transforming growth factor beta 1	Homo sapiens	169-178
31335245-1	2019	Context: We reported that D-4F, an apolipoprotein A-I (Apo A-I) mimetic polypeptide with 18 d-amino acids, suppressed IL-4 induced macrophage alternative activation and TGF-beta1 expression in phorbol 12-myristate 13-acetate (PMA) treated human acute monocytic leukemia cells (THP-1).	Tetradecanoylphorbol Acetate	226-229	apolipoprotein A1	Homo sapiens	55-62
31335245-1	2019	Context: We reported that D-4F, an apolipoprotein A-I (Apo A-I) mimetic polypeptide with 18 d-amino acids, suppressed IL-4 induced macrophage alternative activation and TGF-beta1 expression in phorbol 12-myristate 13-acetate (PMA) treated human acute monocytic leukemia cells (THP-1).	Tetradecanoylphorbol Acetate	226-229	interleukin 4	Homo sapiens	118-122
31496351-9	2019	PMA-induced NETosis directly upregulated the TLR9/NF-kappaB pathway in macrophages and subsequently initiated the release of IL-8.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	50-59
31496351-9	2019	PMA-induced NETosis directly upregulated the TLR9/NF-kappaB pathway in macrophages and subsequently initiated the release of IL-8.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
31327153-5	2019	We show that phorbol 12-myristate 13-acetate (PMA) -activated PKC inhibited Akt activation in neuronal cell, N2a.	Tetradecanoylphorbol Acetate	13-44	thymoma viral proto-oncogene 1	Mus musculus	76-79
31327153-5	2019	We show that phorbol 12-myristate 13-acetate (PMA) -activated PKC inhibited Akt activation in neuronal cell, N2a.	Tetradecanoylphorbol Acetate	46-49	thymoma viral proto-oncogene 1	Mus musculus	76-79
31545439-3	2019	The expression levels of miR-20a in THP-1 cells were significantly reduced in a time-dependent manner during phorbol-12-myristate-13-acetate (PMA), macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappaB ligand RANKL-induced osteoclastogenesis.	Tetradecanoylphorbol Acetate	109-140	microRNA 20a	Homo sapiens	25-32
31545439-3	2019	The expression levels of miR-20a in THP-1 cells were significantly reduced in a time-dependent manner during phorbol-12-myristate-13-acetate (PMA), macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappaB ligand RANKL-induced osteoclastogenesis.	Tetradecanoylphorbol Acetate	142-145	microRNA 20a	Homo sapiens	25-32
31545439-5	2019	In addition, the overexpression of miR-20a inhibited proliferation, initiated S phase cell cycle arrest and induced apoptosis of PMA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	129-132	microRNA 20a	Homo sapiens	35-42
31681277-5	2019	Furthermore, STFRH accelerated phorbol myristate acetate (PMA)-induced NETosis evaluated either by the nuclear DNA decondensation at 2 h post-stimulation or by the increase in extracellular DNA that colocalized with myeloperoxidase (MPO) at 4 h post-stimulation.	Tetradecanoylphorbol Acetate	31-56	myeloperoxidase	Homo sapiens	216-231
31915712-10	2019	Our findings show that SC significantly decreased the percentage of T cells producing TNF-alpha and displayed tendency to decrease IFN-gamma, when stimulated with PMA.	Tetradecanoylphorbol Acetate	163-166	interferon gamma	Homo sapiens	131-140
31681277-5	2019	Furthermore, STFRH accelerated phorbol myristate acetate (PMA)-induced NETosis evaluated either by the nuclear DNA decondensation at 2 h post-stimulation or by the increase in extracellular DNA that colocalized with myeloperoxidase (MPO) at 4 h post-stimulation.	Tetradecanoylphorbol Acetate	31-56	myeloperoxidase	Homo sapiens	233-236
31681277-5	2019	Furthermore, STFRH accelerated phorbol myristate acetate (PMA)-induced NETosis evaluated either by the nuclear DNA decondensation at 2 h post-stimulation or by the increase in extracellular DNA that colocalized with myeloperoxidase (MPO) at 4 h post-stimulation.	Tetradecanoylphorbol Acetate	58-61	myeloperoxidase	Homo sapiens	216-231
31681277-5	2019	Furthermore, STFRH accelerated phorbol myristate acetate (PMA)-induced NETosis evaluated either by the nuclear DNA decondensation at 2 h post-stimulation or by the increase in extracellular DNA that colocalized with myeloperoxidase (MPO) at 4 h post-stimulation.	Tetradecanoylphorbol Acetate	58-61	myeloperoxidase	Homo sapiens	233-236
31334875-3	2019	HYPOTHESIS: We hypothesized that elevated levels of hs-cTnT would be associated with poorer clinical outcomes in AIS patients treated with intravenous tissue-type plasminogen activator (IV tPA).	Tetradecanoylphorbol Acetate	189-192	troponin T2, cardiac type	Homo sapiens	55-59
31506784-7	2019	The expression of COX-2 in a phorbol-12-myristate-13-acetate (PMA)-induced cell model and mammary tumor tissues was examined by Western blotting and immunohistochemistry.	Tetradecanoylphorbol Acetate	29-60	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
31506784-7	2019	The expression of COX-2 in a phorbol-12-myristate-13-acetate (PMA)-induced cell model and mammary tumor tissues was examined by Western blotting and immunohistochemistry.	Tetradecanoylphorbol Acetate	62-65	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	175-206	interferon gamma	Homo sapiens	116-125
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	175-206	interleukin 2	Homo sapiens	130-134
29616829-3	2019	While it has no effect on platelets count, thromboxane B2 levels, and platelet aggregation, testosterone significantly enhanced bleeding time and increased circulatory and thoracic aorta mRNA and protein levels of tPA (46.5%, 58.2%, and 74.3%, respectively) and significantly decreased those of PAI-1 (29.3%, 26.4%, and 32.8%, respectively).	Tetradecanoylphorbol Acetate	214-217	serpin family E member 1	Rattus norvegicus	295-300
31334875-3	2019	HYPOTHESIS: We hypothesized that elevated levels of hs-cTnT would be associated with poorer clinical outcomes in AIS patients treated with intravenous tissue-type plasminogen activator (IV tPA).	Tetradecanoylphorbol Acetate	189-192	plasminogen activator, tissue type	Homo sapiens	151-184
31334875-9	2019	CONCLUSIONS: Elevation of hs-cTnT at admission is associated with an increased risk of 90-day mortality in AIS patients treated with IV tPA.	Tetradecanoylphorbol Acetate	136-139	troponin T2, cardiac type	Homo sapiens	29-33
31351099-8	2019	Consequently, DA significantly reduced the production of NF-kappaB and COX-2 induced proinflammatory cytokine levels on TPA induced ear edema.	Tetradecanoylphorbol Acetate	120-123	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-66
31271729-8	2019	Expression of both TPalpha and TPbeta was upregulated following phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 to their macrophage lineage.	Tetradecanoylphorbol Acetate	64-95	plasminogen activator, tissue type	Homo sapiens	19-26
31271729-8	2019	Expression of both TPalpha and TPbeta was upregulated following phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 to their macrophage lineage.	Tetradecanoylphorbol Acetate	64-95	plasminogen activator, tissue type	Homo sapiens	31-37
31271729-8	2019	Expression of both TPalpha and TPbeta was upregulated following phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 to their macrophage lineage.	Tetradecanoylphorbol Acetate	97-100	plasminogen activator, tissue type	Homo sapiens	19-26
31271729-8	2019	Expression of both TPalpha and TPbeta was upregulated following phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 to their macrophage lineage.	Tetradecanoylphorbol Acetate	97-100	plasminogen activator, tissue type	Homo sapiens	31-37
31351099-0	2019	Decursinol angelate ameliorates 12-O-tetradecanoyl phorbol-13-acetate (TPA) -induced NF-kappaB activation on mice ears by inhibiting exaggerated inflammatory cell infiltration, oxidative stress and pro-inflammatory cytokine production.	Tetradecanoylphorbol Acetate	32-69	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	85-94
31351099-0	2019	Decursinol angelate ameliorates 12-O-tetradecanoyl phorbol-13-acetate (TPA) -induced NF-kappaB activation on mice ears by inhibiting exaggerated inflammatory cell infiltration, oxidative stress and pro-inflammatory cytokine production.	Tetradecanoylphorbol Acetate	71-74	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	85-94
30978354-4	2019	B19V infection increases the production of tumor necrosis factor-alpha and induces NLRP3-mediated caspase-1 activation in both THP-1 cells differentiated with phorbol 12-myristate 13-acetate and in monocytes from patients with SSc but not from healthy controls.	Tetradecanoylphorbol Acetate	159-190	NLR family pyrin domain containing 3	Homo sapiens	83-88
31362059-7	2019	Additionally, IL-9Rhigh CD8+ T cells following anti-TCR and PMA + ionomycin stimulation presented higher IL-2 and IL-17 expression, and lower IFN-gamma expression, than IL-9Rlow CD8+ T cells.	Tetradecanoylphorbol Acetate	60-63	IL2	Sus scrofa	105-109
31362059-7	2019	Additionally, IL-9Rhigh CD8+ T cells following anti-TCR and PMA + ionomycin stimulation presented higher IL-2 and IL-17 expression, and lower IFN-gamma expression, than IL-9Rlow CD8+ T cells.	Tetradecanoylphorbol Acetate	60-63	interferon gamma	Homo sapiens	142-151
31432148-4	2019	Transient transfection and a luciferase assay revealed that the ZNFX1 promoter most prominently responded to the TPA treatment.	Tetradecanoylphorbol Acetate	113-116	zinc finger NFX1-type containing 1	Homo sapiens	64-69
31432148-7	2019	These results indicated that expression of the TPA-inducible ZNFX1 gene, which belongs to the group of interferon-responsive genes, is regulated by the cis-action of the duplicated GGAA motif.	Tetradecanoylphorbol Acetate	47-50	zinc finger NFX1-type containing 1	Homo sapiens	61-66
30978354-4	2019	B19V infection increases the production of tumor necrosis factor-alpha and induces NLRP3-mediated caspase-1 activation in both THP-1 cells differentiated with phorbol 12-myristate 13-acetate and in monocytes from patients with SSc but not from healthy controls.	Tetradecanoylphorbol Acetate	159-190	caspase 1	Homo sapiens	98-107
31632572-7	2019	In an in vitro assay, after treatment with phorbol myristate acetate (PMA), the THP-1 cells differentiated into M2 macrophages and induced COX2/MMP9-dependent invasiveness in GC cells.	Tetradecanoylphorbol Acetate	43-68	prostaglandin-endoperoxide synthase 2	Homo sapiens	139-143
31426030-4	2019	During murine pregnancy, upregulated mCD83 expression induces sCD83 release after in vitro stimulation with LPS, phorbol myristate acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	113-138	CD83 antigen	Mus musculus	37-42
31426030-4	2019	During murine pregnancy, upregulated mCD83 expression induces sCD83 release after in vitro stimulation with LPS, phorbol myristate acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	140-143	CD83 antigen	Mus musculus	37-42
31632572-7	2019	In an in vitro assay, after treatment with phorbol myristate acetate (PMA), the THP-1 cells differentiated into M2 macrophages and induced COX2/MMP9-dependent invasiveness in GC cells.	Tetradecanoylphorbol Acetate	70-73	prostaglandin-endoperoxide synthase 2	Homo sapiens	139-143
31393950-7	2019	A significant inhibition of the ATPase was observed when cells were treated with PMA, an activator of PKC or with 8-Br-cGMP, a cell permeable cGMP analogue.	Tetradecanoylphorbol Acetate	81-84	proline rich transmembrane protein 2	Homo sapiens	102-105
31280407-7	2019	Hal fully blocked in vitro PMA-induced iNOS expression in macrophages and changed their morphology to "anti-inflammatory" phenotype.	Tetradecanoylphorbol Acetate	27-30	nitric oxide synthase 2	Rattus norvegicus	39-43
31181187-5	2019	Knockdown of nuclear factor E2-related factor 2 (Nrf2) in shNrf2 JB6 P+ cells enhanced TPA-induced colony formation and attenuated pelargonidin"s blocking effect.	Tetradecanoylphorbol Acetate	87-90	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
31343893-6	2019	BABP inhibits phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP) expression and activity by blocking mitogen-activated protein kinases (MAPKs) and NF-kappaB signaling and hypoxia-induced vascular endothelial growth factor (VEGF) secretion and hypoxia inducible factor (HIF)-1alpha accumulation through suppressing the AKT/mTOR signal pathway.	Tetradecanoylphorbol Acetate	14-45	vascular endothelial growth factor A	Homo sapiens	213-247
31343893-6	2019	BABP inhibits phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP) expression and activity by blocking mitogen-activated protein kinases (MAPKs) and NF-kappaB signaling and hypoxia-induced vascular endothelial growth factor (VEGF) secretion and hypoxia inducible factor (HIF)-1alpha accumulation through suppressing the AKT/mTOR signal pathway.	Tetradecanoylphorbol Acetate	14-45	vascular endothelial growth factor A	Homo sapiens	249-253
31343893-6	2019	BABP inhibits phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP) expression and activity by blocking mitogen-activated protein kinases (MAPKs) and NF-kappaB signaling and hypoxia-induced vascular endothelial growth factor (VEGF) secretion and hypoxia inducible factor (HIF)-1alpha accumulation through suppressing the AKT/mTOR signal pathway.	Tetradecanoylphorbol Acetate	14-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	269-306
31343893-6	2019	BABP inhibits phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP) expression and activity by blocking mitogen-activated protein kinases (MAPKs) and NF-kappaB signaling and hypoxia-induced vascular endothelial growth factor (VEGF) secretion and hypoxia inducible factor (HIF)-1alpha accumulation through suppressing the AKT/mTOR signal pathway.	Tetradecanoylphorbol Acetate	14-45	AKT serine/threonine kinase 1	Homo sapiens	344-347
31343893-6	2019	BABP inhibits phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP) expression and activity by blocking mitogen-activated protein kinases (MAPKs) and NF-kappaB signaling and hypoxia-induced vascular endothelial growth factor (VEGF) secretion and hypoxia inducible factor (HIF)-1alpha accumulation through suppressing the AKT/mTOR signal pathway.	Tetradecanoylphorbol Acetate	14-45	mechanistic target of rapamycin kinase	Homo sapiens	348-352
31343893-6	2019	BABP inhibits phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP) expression and activity by blocking mitogen-activated protein kinases (MAPKs) and NF-kappaB signaling and hypoxia-induced vascular endothelial growth factor (VEGF) secretion and hypoxia inducible factor (HIF)-1alpha accumulation through suppressing the AKT/mTOR signal pathway.	Tetradecanoylphorbol Acetate	47-50	vascular endothelial growth factor A	Homo sapiens	213-247
31343893-6	2019	BABP inhibits phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP) expression and activity by blocking mitogen-activated protein kinases (MAPKs) and NF-kappaB signaling and hypoxia-induced vascular endothelial growth factor (VEGF) secretion and hypoxia inducible factor (HIF)-1alpha accumulation through suppressing the AKT/mTOR signal pathway.	Tetradecanoylphorbol Acetate	47-50	vascular endothelial growth factor A	Homo sapiens	249-253
31343893-6	2019	BABP inhibits phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP) expression and activity by blocking mitogen-activated protein kinases (MAPKs) and NF-kappaB signaling and hypoxia-induced vascular endothelial growth factor (VEGF) secretion and hypoxia inducible factor (HIF)-1alpha accumulation through suppressing the AKT/mTOR signal pathway.	Tetradecanoylphorbol Acetate	47-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	269-306
31343893-6	2019	BABP inhibits phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP) expression and activity by blocking mitogen-activated protein kinases (MAPKs) and NF-kappaB signaling and hypoxia-induced vascular endothelial growth factor (VEGF) secretion and hypoxia inducible factor (HIF)-1alpha accumulation through suppressing the AKT/mTOR signal pathway.	Tetradecanoylphorbol Acetate	47-50	AKT serine/threonine kinase 1	Homo sapiens	344-347
31343893-6	2019	BABP inhibits phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP) expression and activity by blocking mitogen-activated protein kinases (MAPKs) and NF-kappaB signaling and hypoxia-induced vascular endothelial growth factor (VEGF) secretion and hypoxia inducible factor (HIF)-1alpha accumulation through suppressing the AKT/mTOR signal pathway.	Tetradecanoylphorbol Acetate	47-50	mechanistic target of rapamycin kinase	Homo sapiens	348-352
31484825-6	2019	PKC activation in vivo via injecting phorbol myristate acetate (PMA) or by constitutively active Gqalpha-Q209L in osteocytes and osteoblasts promoted FGF23 production.	Tetradecanoylphorbol Acetate	37-62	protein kinase C, alpha	Mus musculus	0-3
31484825-6	2019	PKC activation in vivo via injecting phorbol myristate acetate (PMA) or by constitutively active Gqalpha-Q209L in osteocytes and osteoblasts promoted FGF23 production.	Tetradecanoylphorbol Acetate	64-67	protein kinase C, alpha	Mus musculus	0-3
32648650-6	2019	Results indicate beta-catenin translocalization and activation of TCF/LEF responsive transcription in response to MNP and magnetic fields, which result in dopaminergic marker expression when synergistically combined with differentiation factors retinoic acid and the phorbol ester phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	281-312	hepatocyte nuclear factor 4 alpha	Homo sapiens	66-73
31238008-4	2019	Phorbol myristate acetate induced TTF1 protein degradation in the ubiquitin-proteasome system in both HTori3 thyroid follicular epithelial cells and follicular thyroid carcinoma 133 (FTC133) cells.	Tetradecanoylphorbol Acetate	0-25	NK2 homeobox 1	Homo sapiens	34-38
30991038-4	2019	RIF treatment significantly induced MDR1 protein and mRNA levels in phorbol 12-myristate 13-acetate-stimulated THP1 macrophages (p &lt; 0.001 and 0.01, respectively).	Tetradecanoylphorbol Acetate	68-99	ATP binding cassette subfamily B member 1	Homo sapiens	36-40
30991038-4	2019	RIF treatment significantly induced MDR1 protein and mRNA levels in phorbol 12-myristate 13-acetate-stimulated THP1 macrophages (p &lt; 0.001 and 0.01, respectively).	Tetradecanoylphorbol Acetate	68-99	GLI family zinc finger 2	Homo sapiens	111-115
31390749-8	2019	This carnosine antioxidant activity was accompanied by the attenuation of the PMA-induced Akt phosphorylation, the down-regulation of TNF-alpha and IL-6 mRNAs, and the up-regulation of the expression of the anti-inflammatory mediators IL-4, IL-10, and TGF-beta1.	Tetradecanoylphorbol Acetate	78-81	interleukin 10	Mus musculus	241-246
31423252-10	2019	It was identified that treatment with interleukin (IL)-4, IL-13 and Phorbol-12-myristate-13-acetate successfully induced THP-1 to form TAMs.	Tetradecanoylphorbol Acetate	68-99	GLI family zinc finger 2	Homo sapiens	121-126
31071452-6	2019	Cell lines transfected with RAC2 [N92 T] displayed characteristics of active GTP-bound RAC2 including enhanced NADPH oxidase-derived superoxide production both at rest and in response to PMA.	Tetradecanoylphorbol Acetate	187-190	Rac family small GTPase 2	Homo sapiens	28-32
31071452-6	2019	Cell lines transfected with RAC2 [N92 T] displayed characteristics of active GTP-bound RAC2 including enhanced NADPH oxidase-derived superoxide production both at rest and in response to PMA.	Tetradecanoylphorbol Acetate	187-190	Rac family small GTPase 2	Homo sapiens	87-91
31361289-6	2019	Furthermore, in a tetradecanoylphorbolacetate (TPA)-treated mouse model, AA and IA could effectively attenuate mouse ear edema and pathological damage and reduced levels of cytokines including iNOS, COX-2, TNF-alpha, and IL-1beta.	Tetradecanoylphorbol Acetate	47-50	tumor necrosis factor	Mus musculus	206-215
31361289-6	2019	Furthermore, in a tetradecanoylphorbolacetate (TPA)-treated mouse model, AA and IA could effectively attenuate mouse ear edema and pathological damage and reduced levels of cytokines including iNOS, COX-2, TNF-alpha, and IL-1beta.	Tetradecanoylphorbol Acetate	47-50	interleukin 1 beta	Mus musculus	221-229
31423543-6	2019	For these purposes, human acute monocytic leukaemia cells (THP-1) were differentiated into macrophages with 12-O-tetradecanoylphorbol-13-acetate (TPA), followed by an incubation with PA or DHA.	Tetradecanoylphorbol Acetate	108-144	GLI family zinc finger 2	Homo sapiens	59-64
31186248-6	2019	Ex vivo, reconstituted T cells, obtained from the tumor-bearing humanized mice, secreted IFNgamma upon treatment with phorbol myristate acetate (PMA) or exposure to human A549 lung tumor cells and mediated antigen-specific CTL responses, indicating functional activity.	Tetradecanoylphorbol Acetate	118-143	interferon gamma	Mus musculus	89-97
31186248-6	2019	Ex vivo, reconstituted T cells, obtained from the tumor-bearing humanized mice, secreted IFNgamma upon treatment with phorbol myristate acetate (PMA) or exposure to human A549 lung tumor cells and mediated antigen-specific CTL responses, indicating functional activity.	Tetradecanoylphorbol Acetate	145-148	interferon gamma	Mus musculus	89-97
30992311-2	2019	It has been reported that human TRESK is activated by the protein kinase C (PKC) activator PMA (phorbol 12-myristate 13-acetate) in Xenopus oocytes.	Tetradecanoylphorbol Acetate	91-94	potassium two pore domain channel subfamily K member 18	Homo sapiens	32-37
30919561-4	2019	In this study, it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells.	Tetradecanoylphorbol Acetate	62-93	interleukin 6	Homo sapiens	108-112
30919561-4	2019	In this study, it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells.	Tetradecanoylphorbol Acetate	95-98	interleukin 6	Homo sapiens	108-112
30919561-4	2019	In this study, it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells.	Tetradecanoylphorbol Acetate	95-98	interleukin 6	Homo sapiens	135-139
31015282-3	2019	We investigated the effects of PKC activation using phorbol 12-myristate 13-acetate (PMA) on hERG channels expressed in human embryonic kidney cell line 293 (HEK293) cells and IKr in isolated neonatal rat ventricular myocytes.	Tetradecanoylphorbol Acetate	52-83	ETS transcription factor ERG	Homo sapiens	93-97
31015282-3	2019	We investigated the effects of PKC activation using phorbol 12-myristate 13-acetate (PMA) on hERG channels expressed in human embryonic kidney cell line 293 (HEK293) cells and IKr in isolated neonatal rat ventricular myocytes.	Tetradecanoylphorbol Acetate	85-88	ETS transcription factor ERG	Homo sapiens	93-97
31015282-4	2019	Acute activation of PKC by PMA (30 nM, 30 minutes) reduced both hERG current (IhERG) and IKr Chronic activation of PKC by PMA (30 nM, 16 hours) increased IKr in cardiomyocytes and the expression level of hERG proteins; however, chronic (30 nM, 16 hours) PMA treatment decreased IhERG, which became larger than untreated control IhERG after PMA removal for 4 hours.	Tetradecanoylphorbol Acetate	27-30	ETS transcription factor ERG	Homo sapiens	64-68
31015282-4	2019	Acute activation of PKC by PMA (30 nM, 30 minutes) reduced both hERG current (IhERG) and IKr Chronic activation of PKC by PMA (30 nM, 16 hours) increased IKr in cardiomyocytes and the expression level of hERG proteins; however, chronic (30 nM, 16 hours) PMA treatment decreased IhERG, which became larger than untreated control IhERG after PMA removal for 4 hours.	Tetradecanoylphorbol Acetate	27-30	ETS transcription factor ERG	Homo sapiens	79-83
31015282-4	2019	Acute activation of PKC by PMA (30 nM, 30 minutes) reduced both hERG current (IhERG) and IKr Chronic activation of PKC by PMA (30 nM, 16 hours) increased IKr in cardiomyocytes and the expression level of hERG proteins; however, chronic (30 nM, 16 hours) PMA treatment decreased IhERG, which became larger than untreated control IhERG after PMA removal for 4 hours.	Tetradecanoylphorbol Acetate	122-125	ETS transcription factor ERG	Homo sapiens	64-68
31015282-4	2019	Acute activation of PKC by PMA (30 nM, 30 minutes) reduced both hERG current (IhERG) and IKr Chronic activation of PKC by PMA (30 nM, 16 hours) increased IKr in cardiomyocytes and the expression level of hERG proteins; however, chronic (30 nM, 16 hours) PMA treatment decreased IhERG, which became larger than untreated control IhERG after PMA removal for 4 hours.	Tetradecanoylphorbol Acetate	122-125	ETS transcription factor ERG	Homo sapiens	79-83
31053301-3	2019	TPA as an activator of the ERK pathway markedly induced ErbB4 phosphorylation at Thr-674, the conserved common feedback site in the intracellular JM domain, which resulted in the downregulation of tyrosine autophosphorylation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	27-30
31285782-9	2019	We found that PMA induced tyrosine phosphorylation of protein tyrosine kinases (PTKs), such as focal adhesion kinase (FAK), protein tyrosine kinase 2 (Pyk2), and Src, and increased actin stress fiber formation in a ROS-dependent manner.	Tetradecanoylphorbol Acetate	14-17	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	162-165
30849519-6	2019	Furthermore, we demonstrate that an E3 ubiquitin ligase, named HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HECW1), targets TTF1 for its ubiquitination and degradation, while downregulation of HECW1 attenuates PMA-induced TTF1 ubiquitination and degradation.	Tetradecanoylphorbol Acetate	230-233	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	Homo sapiens	128-133
30849519-6	2019	Furthermore, we demonstrate that an E3 ubiquitin ligase, named HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HECW1), targets TTF1 for its ubiquitination and degradation, while downregulation of HECW1 attenuates PMA-induced TTF1 ubiquitination and degradation.	Tetradecanoylphorbol Acetate	230-233	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	Homo sapiens	213-218
30707387-3	2019	After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages.	Tetradecanoylphorbol Acetate	66-69	AKT serine/threonine kinase 1	Homo sapiens	287-290
30707387-3	2019	After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages.	Tetradecanoylphorbol Acetate	66-69	AKT serine/threonine kinase 1	Homo sapiens	294-297
31025213-11	2019	Wortmannin suppressed the PMA-induced phosphorylation of Akt in endothelial cells.	Tetradecanoylphorbol Acetate	26-29	AKT serine/threonine kinase 1	Rattus norvegicus	57-60
30992311-2	2019	It has been reported that human TRESK is activated by the protein kinase C (PKC) activator PMA (phorbol 12-myristate 13-acetate) in Xenopus oocytes.	Tetradecanoylphorbol Acetate	91-94	proline rich transmembrane protein 2	Homo sapiens	58-74
30992311-2	2019	It has been reported that human TRESK is activated by the protein kinase C (PKC) activator PMA (phorbol 12-myristate 13-acetate) in Xenopus oocytes.	Tetradecanoylphorbol Acetate	91-94	proline rich transmembrane protein 2	Homo sapiens	76-79
30992311-2	2019	It has been reported that human TRESK is activated by the protein kinase C (PKC) activator PMA (phorbol 12-myristate 13-acetate) in Xenopus oocytes.	Tetradecanoylphorbol Acetate	96-127	potassium two pore domain channel subfamily K member 18	Homo sapiens	32-37
30992311-2	2019	It has been reported that human TRESK is activated by the protein kinase C (PKC) activator PMA (phorbol 12-myristate 13-acetate) in Xenopus oocytes.	Tetradecanoylphorbol Acetate	96-127	proline rich transmembrane protein 2	Homo sapiens	58-74
30992311-2	2019	It has been reported that human TRESK is activated by the protein kinase C (PKC) activator PMA (phorbol 12-myristate 13-acetate) in Xenopus oocytes.	Tetradecanoylphorbol Acetate	96-127	proline rich transmembrane protein 2	Homo sapiens	76-79
31275997-4	2019	In the presence of patient serum, IFN-gamma-induced type 1 macrophage (M1) differentiation was inhibited in PMA-stimulated human monocytic THP-1 cells.	Tetradecanoylphorbol Acetate	108-111	interferon gamma	Homo sapiens	34-43
31214286-5	2019	Consistent with in vitro studies, BG10 (0.5 mg/mL) not only reduced ear edema but also suppressed the formation of IL-6 and TNF-alpha induced by 12-O-tetradecanoylphorbol-13-acetate in ear tissues of mice.	Tetradecanoylphorbol Acetate	145-181	interleukin 6	Mus musculus	115-119
31214286-5	2019	Consistent with in vitro studies, BG10 (0.5 mg/mL) not only reduced ear edema but also suppressed the formation of IL-6 and TNF-alpha induced by 12-O-tetradecanoylphorbol-13-acetate in ear tissues of mice.	Tetradecanoylphorbol Acetate	145-181	tumor necrosis factor	Mus musculus	124-133
31111899-4	2019	ABCG1 phosphorylation was enhanced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	91-94	ATP binding cassette subfamily G member 1	Homo sapiens	0-5
31142080-2	2019	Methods: THP-1 monocyte was incubated with PMA for 48 hours to induce the differentiation into macrophages.	Tetradecanoylphorbol Acetate	43-46	GLI family zinc finger 2	Homo sapiens	9-14
31111899-4	2019	ABCG1 phosphorylation was enhanced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	53-89	ATP binding cassette subfamily G member 1	Homo sapiens	0-5
31070650-2	2019	The present research was carried out to investigate the protective effect of total polysaccharides of adlay bran (TPA) on TNF-alpha-evoked epithelial barrier dysfunction in Caco-2 cells.	Tetradecanoylphorbol Acetate	114-117	tumor necrosis factor	Homo sapiens	122-131
31070650-4	2019	The results indicated that TPA suppressed the TNF-alpha-induced release of pro-inflammatory factors.	Tetradecanoylphorbol Acetate	27-30	tumor necrosis factor	Homo sapiens	46-55
31070650-5	2019	Furthermore, TPA obviously assuaged both the increased paracellular permeability and the decrease of TEER in TNF-alpha-challenged Caco-2 cells.	Tetradecanoylphorbol Acetate	13-16	tumor necrosis factor	Homo sapiens	109-118
31070650-6	2019	Furthermore, TPA obviously assuaged TNF-alpha-evoked up-regulation of IL-8 and IL-6 expression, down-regulation of occludin and ZO-3 expression, and markedly suppressed the activation and protein expression of NF-kappaB p65.	Tetradecanoylphorbol Acetate	13-16	tumor necrosis factor	Homo sapiens	36-45
31070650-6	2019	Furthermore, TPA obviously assuaged TNF-alpha-evoked up-regulation of IL-8 and IL-6 expression, down-regulation of occludin and ZO-3 expression, and markedly suppressed the activation and protein expression of NF-kappaB p65.	Tetradecanoylphorbol Acetate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
31070650-6	2019	Furthermore, TPA obviously assuaged TNF-alpha-evoked up-regulation of IL-8 and IL-6 expression, down-regulation of occludin and ZO-3 expression, and markedly suppressed the activation and protein expression of NF-kappaB p65.	Tetradecanoylphorbol Acetate	13-16	interleukin 6	Homo sapiens	79-83
31070650-6	2019	Furthermore, TPA obviously assuaged TNF-alpha-evoked up-regulation of IL-8 and IL-6 expression, down-regulation of occludin and ZO-3 expression, and markedly suppressed the activation and protein expression of NF-kappaB p65.	Tetradecanoylphorbol Acetate	13-16	nuclear factor kappa B subunit 1	Homo sapiens	210-219
31070650-7	2019	Our results indicated that TPA assuages the TNF-alpha-evoked dysfunction of the intestinal epithelial barrier by inhibiting the NF-kappaB p65-mediated inflammatory response.	Tetradecanoylphorbol Acetate	27-30	tumor necrosis factor	Homo sapiens	44-53
31070650-7	2019	Our results indicated that TPA assuages the TNF-alpha-evoked dysfunction of the intestinal epithelial barrier by inhibiting the NF-kappaB p65-mediated inflammatory response.	Tetradecanoylphorbol Acetate	27-30	nuclear factor kappa B subunit 1	Homo sapiens	128-137
30936203-4	2019	Our results demonstrate that direct activation of PKC via the phorbol ester phorbol 12-myristate 13-acetate (PMA) mimics CXCL12-mediated desensitization, internalization, ubiquitination, and lysosomal trafficking of CXCR4.	Tetradecanoylphorbol Acetate	76-107	proline rich transmembrane protein 2	Homo sapiens	50-53
30936203-4	2019	Our results demonstrate that direct activation of PKC via the phorbol ester phorbol 12-myristate 13-acetate (PMA) mimics CXCL12-mediated desensitization, internalization, ubiquitination, and lysosomal trafficking of CXCR4.	Tetradecanoylphorbol Acetate	109-112	proline rich transmembrane protein 2	Homo sapiens	50-53
31111899-4	2019	ABCG1 phosphorylation was enhanced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	53-89	protein kinase C alpha	Homo sapiens	117-120
31111899-4	2019	ABCG1 phosphorylation was enhanced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	91-94	protein kinase C alpha	Homo sapiens	117-120
31111899-5	2019	PKC activation by TPA increased ABCG1 protein levels and promoted ABCG1-dependent cholesterol efflux to HDL.	Tetradecanoylphorbol Acetate	18-21	protein kinase C alpha	Homo sapiens	0-3
31111899-5	2019	PKC activation by TPA increased ABCG1 protein levels and promoted ABCG1-dependent cholesterol efflux to HDL.	Tetradecanoylphorbol Acetate	18-21	ATP binding cassette subfamily G member 1	Homo sapiens	32-37
31111899-5	2019	PKC activation by TPA increased ABCG1 protein levels and promoted ABCG1-dependent cholesterol efflux to HDL.	Tetradecanoylphorbol Acetate	18-21	ATP binding cassette subfamily G member 1	Homo sapiens	66-71
31020588-2	2019	Preincubation of Jurkat cells with Ergoferon increased IL-2 secretion by these cells after stimulation with phorbol 12-myristate 13-acetate/ionomycine in comparison with the placebo group.	Tetradecanoylphorbol Acetate	108-139	interleukin 2	Homo sapiens	55-59
30726114-5	2019	Meanwhile, fMLF or IL-8 stimulation yields the longer terminating time than that on PMA stimulation but results in a similar shedding extent for PMNs.	Tetradecanoylphorbol Acetate	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	19-23
30793846-11	2019	All O-2",3"-guanosine ketals were tested on their cytostatic/cytotoxic activity towards phorbol 12-myristate 13-acetate (PMA)-differentiated human THP-1 macrophages as well as against human astrocytoma/oligodendroglioma GOS-3 cells and against rat malignant neuroectodermal BT4Ca cells.	Tetradecanoylphorbol Acetate	121-124	GLI family zinc finger 2	Homo sapiens	147-152
30976816-8	2019	Caspase-1 activity was increased by exposure to phorbol myristate acetate plus calcium ionophore, whereas it was reduced by UA.	Tetradecanoylphorbol Acetate	48-73	caspase 1	Homo sapiens	0-9
30248704-0	2019	Serine Protease Mauritanicain from Euphorbia mauritanica and Phorbol-12-myristate-13-acetate Modulate the IL-8 Release in Fibroblasts and HaCaT Keratinocytes.	Tetradecanoylphorbol Acetate	61-92	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
30248704-7	2019	The results indicated that the combination of the protease mauritanicain from Euphorbia mauritanica and phorbol-12-myristate-13-acetate induced a significantly increased IL-8 release in HaCaT keratinocytes compared to single treatments.	Tetradecanoylphorbol Acetate	104-135	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
30894371-2	2019	Here, we showed that these mice were also resistant to 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumor formation.	Tetradecanoylphorbol Acetate	93-129	promotion susceptibility QTL 1	Mus musculus	131-134
31010051-3	2019	Upon stimulating IL-32theta-expressing and non-expressing cells with phorbol 12-myristate 13-acetate (PMA), the previous microarray analysis showed that IL-13Ralpha2 and IL-13 mRNA expression were significantly decreased by IL-32theta.	Tetradecanoylphorbol Acetate	69-100	interleukin 13	Homo sapiens	153-158
31010051-3	2019	Upon stimulating IL-32theta-expressing and non-expressing cells with phorbol 12-myristate 13-acetate (PMA), the previous microarray analysis showed that IL-13Ralpha2 and IL-13 mRNA expression were significantly decreased by IL-32theta.	Tetradecanoylphorbol Acetate	102-105	interleukin 13	Homo sapiens	153-158
30998783-5	2019	As for effector functions, IFNgamma/TNF responses to phosphoantigens or PMA/Ionomycin in Vdelta2+gammadeltaT-cells were weaker in AHB but preserved in CHB, without significant differences for Vdelta1+gammadeltaT-cells.	Tetradecanoylphorbol Acetate	72-75	tumor necrosis factor	Homo sapiens	36-39
30934690-4	2019	Conditional keratinocyte-specific p38delta ablation (p38delta-cKO K) did not influence the latency, incidence, or multiplicity of chemically-induced skin tumors, but led to increased tumor volume in females during the TPA promotion stage, and reduced malignant progression in males and females relative to their wild-type counterparts.	Tetradecanoylphorbol Acetate	218-221	mitogen-activated protein kinase 13	Homo sapiens	34-42
30776542-3	2019	To further reveal the mediated mechanism that Nrf2 active state was affected by protein kinase C (PKC), here we evaluated SVCV replication in host cells by treated with a strong activator of PKC phorbol-12-myristate-13-acetate (PMA) and an inhibitor staurosporine.	Tetradecanoylphorbol Acetate	195-226	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
30776542-3	2019	To further reveal the mediated mechanism that Nrf2 active state was affected by protein kinase C (PKC), here we evaluated SVCV replication in host cells by treated with a strong activator of PKC phorbol-12-myristate-13-acetate (PMA) and an inhibitor staurosporine.	Tetradecanoylphorbol Acetate	228-231	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
30776542-3	2019	To further reveal the mediated mechanism that Nrf2 active state was affected by protein kinase C (PKC), here we evaluated SVCV replication in host cells by treated with a strong activator of PKC phorbol-12-myristate-13-acetate (PMA) and an inhibitor staurosporine.	Tetradecanoylphorbol Acetate	228-231	protein kinase C alpha	Homo sapiens	98-101
30642680-1	2019	BACKGROUND AND PURPOSE: Recent studies demonstrated the benefit of mechanical thrombectomy (MT) plus intravenous tissue-type plasminogen activator (IV-tPA) (MT-IV-tPA) in acute ischemic stroke.	Tetradecanoylphorbol Acetate	151-154	plasminogen activator, tissue type	Homo sapiens	113-146
30934690-5	2019	In contrast, conditional myeloid cell-specific p38delta deletion (p38delta-cKO M) inhibited DMBA/TPA-induced skin tumorigenesis in male but not female mice.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 13	Homo sapiens	47-55
30934690-5	2019	In contrast, conditional myeloid cell-specific p38delta deletion (p38delta-cKO M) inhibited DMBA/TPA-induced skin tumorigenesis in male but not female mice.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 13	Homo sapiens	66-74
30941128-10	2019	Fetal liver and spleen NK cells displayed limited cytotoxic effector function in chromium release assays but produced copious amounts of TNFalpha and IFNgamma, and degranulated efficiently in response to stimulation with PMA/ionomycin.	Tetradecanoylphorbol Acetate	221-224	tumor necrosis factor	Homo sapiens	137-145
30941128-10	2019	Fetal liver and spleen NK cells displayed limited cytotoxic effector function in chromium release assays but produced copious amounts of TNFalpha and IFNgamma, and degranulated efficiently in response to stimulation with PMA/ionomycin.	Tetradecanoylphorbol Acetate	221-224	interferon gamma	Homo sapiens	150-158
30395261-5	2019	TACE was identified as the protease responsible for phorbol 12-myristate 13-acetate (PMA)-induced VCAM-1 release in murine endothelial cells.	Tetradecanoylphorbol Acetate	52-83	a disintegrin and metallopeptidase domain 17	Mus musculus	0-4
30886319-4	2019	Stimulation of P5424 cells by the calcium ionophore ionomycin together with PMA resulted in gene regulation of T-cell differentiation and activation markers, partially mimicking the CD4-CD8- double negative (DN) to double positive (DP) transition and some aspects of subsequent T-cell maturation and activation.	Tetradecanoylphorbol Acetate	76-79	CD4 molecule	Homo sapiens	182-185
30771312-0	2019	Propofol specifically reduces PMA-induced neutrophil extracellular trap formation through inhibition of p-ERK and HOCl.	Tetradecanoylphorbol Acetate	30-33	mitogen-activated protein kinase 1	Homo sapiens	106-109
30871060-9	2019	GA also inhibited the PMA-induced phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta), c-Jun N-terminal kinase (JNK) and p38 proteins (P38), suggesting that IKKalpha/beta, JNK and P38 activation is dependent on PKC activity.	Tetradecanoylphorbol Acetate	22-25	mitogen-activated protein kinase 8	Homo sapiens	96-119
30871060-9	2019	GA also inhibited the PMA-induced phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta), c-Jun N-terminal kinase (JNK) and p38 proteins (P38), suggesting that IKKalpha/beta, JNK and P38 activation is dependent on PKC activity.	Tetradecanoylphorbol Acetate	22-25	mitogen-activated protein kinase 8	Homo sapiens	121-124
30871060-9	2019	GA also inhibited the PMA-induced phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta), c-Jun N-terminal kinase (JNK) and p38 proteins (P38), suggesting that IKKalpha/beta, JNK and P38 activation is dependent on PKC activity.	Tetradecanoylphorbol Acetate	22-25	mitogen-activated protein kinase 14	Homo sapiens	130-133
30871060-9	2019	GA also inhibited the PMA-induced phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta), c-Jun N-terminal kinase (JNK) and p38 proteins (P38), suggesting that IKKalpha/beta, JNK and P38 activation is dependent on PKC activity.	Tetradecanoylphorbol Acetate	22-25	mitogen-activated protein kinase 14	Homo sapiens	144-147
30871060-9	2019	GA also inhibited the PMA-induced phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta), c-Jun N-terminal kinase (JNK) and p38 proteins (P38), suggesting that IKKalpha/beta, JNK and P38 activation is dependent on PKC activity.	Tetradecanoylphorbol Acetate	22-25	mitogen-activated protein kinase 8	Homo sapiens	181-184
30871060-9	2019	GA also inhibited the PMA-induced phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta), c-Jun N-terminal kinase (JNK) and p38 proteins (P38), suggesting that IKKalpha/beta, JNK and P38 activation is dependent on PKC activity.	Tetradecanoylphorbol Acetate	22-25	mitogen-activated protein kinase 14	Homo sapiens	189-192
30590137-0	2019	Suppression of PMA-induced human fibrosarcoma HT-1080 invasion and metastasis by kahweol via inhibiting Akt/JNK1/2/p38 MAPK signal pathway and NF-kappaB dependent transcriptional activities.	Tetradecanoylphorbol Acetate	15-18	AKT serine/threonine kinase 1	Homo sapiens	104-107
30590137-0	2019	Suppression of PMA-induced human fibrosarcoma HT-1080 invasion and metastasis by kahweol via inhibiting Akt/JNK1/2/p38 MAPK signal pathway and NF-kappaB dependent transcriptional activities.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 8	Homo sapiens	108-114
30590137-0	2019	Suppression of PMA-induced human fibrosarcoma HT-1080 invasion and metastasis by kahweol via inhibiting Akt/JNK1/2/p38 MAPK signal pathway and NF-kappaB dependent transcriptional activities.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 14	Homo sapiens	115-118
30590137-0	2019	Suppression of PMA-induced human fibrosarcoma HT-1080 invasion and metastasis by kahweol via inhibiting Akt/JNK1/2/p38 MAPK signal pathway and NF-kappaB dependent transcriptional activities.	Tetradecanoylphorbol Acetate	15-18	nuclear factor kappa B subunit 1	Homo sapiens	143-152
30590137-8	2019	KA repressed the PMA-induced phosphorylation of Akt, c-Jun N-terminal kinase (JNK) 1/2, and p38 MAPK, which are signaling molecules upstream of MMP-9 expression.	Tetradecanoylphorbol Acetate	17-20	AKT serine/threonine kinase 1	Homo sapiens	48-51
30590137-8	2019	KA repressed the PMA-induced phosphorylation of Akt, c-Jun N-terminal kinase (JNK) 1/2, and p38 MAPK, which are signaling molecules upstream of MMP-9 expression.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase 8	Homo sapiens	53-86
30590137-8	2019	KA repressed the PMA-induced phosphorylation of Akt, c-Jun N-terminal kinase (JNK) 1/2, and p38 MAPK, which are signaling molecules upstream of MMP-9 expression.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase 14	Homo sapiens	92-95
30721636-9	2019	Both Con A and PMA + Ion-induced secretion of IL-2, IFN-gamma, and TNF-alpha were attenuated by PHI.	Tetradecanoylphorbol Acetate	15-18	interferon gamma	Mus musculus	52-61
30721636-9	2019	Both Con A and PMA + Ion-induced secretion of IL-2, IFN-gamma, and TNF-alpha were attenuated by PHI.	Tetradecanoylphorbol Acetate	15-18	tumor necrosis factor	Mus musculus	67-76
30617997-7	2019	RESULTS: Among patients with NIHSS &lt; 8 (N = 193, 77/193, 39.9% receiving pre-interventional IV-tPA), successful reperfusion was significantly related to mRS 0-1 (aOR 3.217, 95%-CI 1.174-8.816) and reduced the chances of non-hemorrhagic neurological worsening (aOR 0.194, 95%-CI 0.050-0.756) after adjusting for prespecified confounders.	Tetradecanoylphorbol Acetate	98-101	retinoschisis (X-linked, juvenile) 1 (human)	Mus musculus	156-163
30658316-5	2019	The PKC activator 12-O-tetradecanoylphorbol 13-acetate (TPA) was used to investigate the effect of PKC activity on claudin 1 transcription and protein levels, subcellular distribution, and alterations in EMT markers in human breast cancer (HBC) cell lines.	Tetradecanoylphorbol Acetate	18-54	proline rich transmembrane protein 2	Homo sapiens	4-7
30838000-8	2019	Upon in vitro activation with PMA plus ionomycin or IL12 plus IL18, fewer MAIT cells isolated from the young adult group expressed IFN-gamma, IL17A and Granzyme B then cells from other age groups while the proportion of cells that expressed TNF-alpha was similar.	Tetradecanoylphorbol Acetate	30-33	interferon gamma	Homo sapiens	131-140
30838000-8	2019	Upon in vitro activation with PMA plus ionomycin or IL12 plus IL18, fewer MAIT cells isolated from the young adult group expressed IFN-gamma, IL17A and Granzyme B then cells from other age groups while the proportion of cells that expressed TNF-alpha was similar.	Tetradecanoylphorbol Acetate	30-33	tumor necrosis factor	Homo sapiens	241-250
30777021-7	2019	Overexpression of c-Fos and c-Jun proteins or stimulation with PMA/Ionomycin significantly increases mRNA expression of FGF7 in fibroblast cells.	Tetradecanoylphorbol Acetate	63-66	fibroblast growth factor 7	Homo sapiens	120-124
30566262-8	2019	Up-regulation of cytokines (TSLP, IL-4, IL-5, IL-13, RANTES) in human mast cells treated with phorbol 12-myristate 13-acetate and calcium ionophore was also suppressed by boehmite.	Tetradecanoylphorbol Acetate	94-125	interleukin 4	Homo sapiens	34-38
30566262-8	2019	Up-regulation of cytokines (TSLP, IL-4, IL-5, IL-13, RANTES) in human mast cells treated with phorbol 12-myristate 13-acetate and calcium ionophore was also suppressed by boehmite.	Tetradecanoylphorbol Acetate	94-125	interleukin 13	Homo sapiens	46-51
30511745-9	2019	Restoration of diacylglycerol-mediated signalling in lipin1 deficient myoblasts by phorbol 12-myristate 13-acetate transiently activated PKC and HDAC5, and upregulated MEF2c expression.	Tetradecanoylphorbol Acetate	83-114	histone deacetylase 5	Mus musculus	145-150
30511745-9	2019	Restoration of diacylglycerol-mediated signalling in lipin1 deficient myoblasts by phorbol 12-myristate 13-acetate transiently activated PKC and HDAC5, and upregulated MEF2c expression.	Tetradecanoylphorbol Acetate	83-114	myocyte enhancer factor 2C	Mus musculus	168-173
30395261-5	2019	TACE was identified as the protease responsible for phorbol 12-myristate 13-acetate (PMA)-induced VCAM-1 release in murine endothelial cells.	Tetradecanoylphorbol Acetate	85-88	a disintegrin and metallopeptidase domain 17	Mus musculus	0-4
30616203-5	2019	As a possible link between STAT3, p53-p21 and KSHV lytic cycle, we found that TPA and AG490 reduced the expression of KAP-1, promoting p53 stability, p21 transcription and KSHV lytic cycle activation in PEL cells.	Tetradecanoylphorbol Acetate	78-81	signal transducer and activator of transcription 3	Homo sapiens	27-32
30218697-0	2019	Di-n-butyl phthalate modifies PMA-induced macrophage differentiation of THP-1 monocytes via PPARgamma.	Tetradecanoylphorbol Acetate	30-33	GLI family zinc finger 2	Homo sapiens	72-77
30218697-0	2019	Di-n-butyl phthalate modifies PMA-induced macrophage differentiation of THP-1 monocytes via PPARgamma.	Tetradecanoylphorbol Acetate	30-33	peroxisome proliferator activated receptor gamma	Homo sapiens	92-101
30218697-1	2019	The present study examined the effects of di-n-butyl phthalate (DBP) on phorbol myristate acetate (PMA)-induced macrophage differentiation of THP-1 monocytes, determined by morphological classification and flow cytometry.	Tetradecanoylphorbol Acetate	72-97	GLI family zinc finger 2	Homo sapiens	142-147
30218697-1	2019	The present study examined the effects of di-n-butyl phthalate (DBP) on phorbol myristate acetate (PMA)-induced macrophage differentiation of THP-1 monocytes, determined by morphological classification and flow cytometry.	Tetradecanoylphorbol Acetate	99-102	GLI family zinc finger 2	Homo sapiens	142-147
30218697-10	2019	Overall, the results show that DBP modifies PMA-induced differentiation of THP-1 cells through interaction with PPARgamma.	Tetradecanoylphorbol Acetate	44-47	GLI family zinc finger 2	Homo sapiens	75-80
30218697-10	2019	Overall, the results show that DBP modifies PMA-induced differentiation of THP-1 cells through interaction with PPARgamma.	Tetradecanoylphorbol Acetate	44-47	peroxisome proliferator activated receptor gamma	Homo sapiens	112-121
30406221-3	2019	In order to monitor O2 - level fluctuations in living cells, we synthesized two reaction-type probes of TPA-DHP-1,2,3 and TPA-PPA-1,2,3, which were composed of an electron-rich triphenylamine (TPA) and the very active functional groups of dihydropyridine (DHP) and pyridinium (PPA).	Tetradecanoylphorbol Acetate	122-125	inorganic pyrophosphatase 1	Homo sapiens	126-135
30406221-3	2019	In order to monitor O2 - level fluctuations in living cells, we synthesized two reaction-type probes of TPA-DHP-1,2,3 and TPA-PPA-1,2,3, which were composed of an electron-rich triphenylamine (TPA) and the very active functional groups of dihydropyridine (DHP) and pyridinium (PPA).	Tetradecanoylphorbol Acetate	122-125	inorganic pyrophosphatase 1	Homo sapiens	126-135
30522955-5	2019	Notably, the novel pseudotripeptides influenced inflammatory cytokine expression (IL-1beta, IL-18, and TNF-alpha) in Abeta25-35-, PMA-, and LPS-treated THP-1 cells.	Tetradecanoylphorbol Acetate	130-133	tumor necrosis factor	Homo sapiens	103-112
30645596-4	2019	Phorbol-12-myristate-13-acetate (PMA), a PKCalpha activator, significantly increased the activity and expression of matrix metalloproteinases (MMP) -2 and -9 in human (late outgrowth) EPCs in vitro.	Tetradecanoylphorbol Acetate	0-31	protein kinase C alpha	Homo sapiens	41-49
30645596-4	2019	Phorbol-12-myristate-13-acetate (PMA), a PKCalpha activator, significantly increased the activity and expression of matrix metalloproteinases (MMP) -2 and -9 in human (late outgrowth) EPCs in vitro.	Tetradecanoylphorbol Acetate	33-36	protein kinase C alpha	Homo sapiens	41-49
30645596-11	2019	PMA could activate PKCalpha and promote the angiogenesis capacity of human EPCs via NADPH oxidase-mediated, redox-related, MMP-2 and MMP-9 pathways.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	19-27
31026389-0	2019	Praeruptorin-B Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Invasion by Targeting AKT/NF-kappaB via Matrix Metalloproteinase-2/-9 Expression in Human Cervical Cancer Cells.	Tetradecanoylphorbol Acetate	24-60	AKT serine/threonine kinase 1	Homo sapiens	96-99
31026389-0	2019	Praeruptorin-B Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Invasion by Targeting AKT/NF-kappaB via Matrix Metalloproteinase-2/-9 Expression in Human Cervical Cancer Cells.	Tetradecanoylphorbol Acetate	24-60	nuclear factor kappa B subunit 1	Homo sapiens	100-109
31026389-10	2019	In addition, Pra-B attenuated TPA-induced nuclear translocation of NF-kappaB-p65/-p50, which reduced Ikk-alpha phosphorylation in HeLa cells.	Tetradecanoylphorbol Acetate	30-33	nuclear factor kappa B subunit 1	Homo sapiens	67-76
31026389-11	2019	Cotreatment of HeLa cells with TPA plus Pra-B or LY294002 reduced NF-kappaB nuclear translocation.	Tetradecanoylphorbol Acetate	31-34	nuclear factor kappa B subunit 1	Homo sapiens	66-75
31026389-12	2019	CONCLUSION: These results suggested that Pra-B-mediated inhibition of TPA-induced cell metastasis involved the suppression of p-AKT/NF-kappaB via MMP-2/-9 expression in HeLa cells.	Tetradecanoylphorbol Acetate	70-73	AKT serine/threonine kinase 1	Homo sapiens	128-131
31026389-12	2019	CONCLUSION: These results suggested that Pra-B-mediated inhibition of TPA-induced cell metastasis involved the suppression of p-AKT/NF-kappaB via MMP-2/-9 expression in HeLa cells.	Tetradecanoylphorbol Acetate	70-73	nuclear factor kappa B subunit 1	Homo sapiens	132-141
30321531-5	2018	TPA-induced activation of NF-kappaB was also markedly suppressed by KB-34 in HT-29 cells.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	26-35
30393145-6	2019	THP-1 cells were differentiated with phorbol-12-myristate-13-acetate (20 ng/ml, 48 h).	Tetradecanoylphorbol Acetate	37-68	GLI family zinc finger 2	Homo sapiens	0-5
30323026-5	2019	Suppression of IL-8 in human embryonic kidney (HEK293) cells that were transformed to express TLR5 was observed not only upon inflammatory stimulation by flagellin but also in response to tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), despite the fact that the TNF-alpha- and PMA-induced inflammatory pathways reportedly are not TLR5 mediated.	Tetradecanoylphorbol Acetate	232-257	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
30323026-5	2019	Suppression of IL-8 in human embryonic kidney (HEK293) cells that were transformed to express TLR5 was observed not only upon inflammatory stimulation by flagellin but also in response to tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), despite the fact that the TNF-alpha- and PMA-induced inflammatory pathways reportedly are not TLR5 mediated.	Tetradecanoylphorbol Acetate	259-262	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
30323026-5	2019	Suppression of IL-8 in human embryonic kidney (HEK293) cells that were transformed to express TLR5 was observed not only upon inflammatory stimulation by flagellin but also in response to tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), despite the fact that the TNF-alpha- and PMA-induced inflammatory pathways reportedly are not TLR5 mediated.	Tetradecanoylphorbol Acetate	306-309	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
30665329-7	2019	PMA dose-dependently upregulated ppNOC mRNA but downregulated NOP mRNA in human peripheral blood leukocytes.	Tetradecanoylphorbol Acetate	0-3	prepronociceptin	Homo sapiens	33-38
30665329-11	2019	The combination of ERK and p38 inhibitors completely reversed the effects of PMA ( P &lt;0.05).	Tetradecanoylphorbol Acetate	77-80	mitogen-activated protein kinase 14	Homo sapiens	27-30
30588093-0	2018	An individual reference limit of the serum CEA-TPA-CA 15-3 tumor marker panel in the surveillance of asymptomatic women following surgery for primary breast cancer.	Tetradecanoylphorbol Acetate	47-50	CEA cell adhesion molecule 3	Homo sapiens	43-46
30588093-4	2018	Results: Sensitivity, specificity, and accuracy of the combined CEA-TPA-CA 15-3 marker panel for predicting patient outcome were 95.2%, 97.8%, and 97.9%, respectively.	Tetradecanoylphorbol Acetate	68-71	CEA cell adhesion molecule 3	Homo sapiens	64-67
30518116-5	2018	We concluded that CGA isomers exert anti-inflammatory activity in a mixture of interferon gamma (IFNgamma) and phorbol myristate acetate (PMA)-challenged Caco-2 cells, by decreasing the phosphorylation of p38 cascade and up-regulating NFkappaB signaling.	Tetradecanoylphorbol Acetate	111-136	mitogen-activated protein kinase 14	Homo sapiens	205-208
31194000-2	2019	The phorbol 12-myristate 13-acetate and Forskolin (Fo) are well-known kinase activators/stimulators of Protein Kinase C (PKC) and Protein Kinase A (PKA) respectively.	Tetradecanoylphorbol Acetate	4-35	proline rich transmembrane protein 2	Homo sapiens	103-119
31194000-2	2019	The phorbol 12-myristate 13-acetate and Forskolin (Fo) are well-known kinase activators/stimulators of Protein Kinase C (PKC) and Protein Kinase A (PKA) respectively.	Tetradecanoylphorbol Acetate	4-35	proline rich transmembrane protein 2	Homo sapiens	121-124
30518116-5	2018	We concluded that CGA isomers exert anti-inflammatory activity in a mixture of interferon gamma (IFNgamma) and phorbol myristate acetate (PMA)-challenged Caco-2 cells, by decreasing the phosphorylation of p38 cascade and up-regulating NFkappaB signaling.	Tetradecanoylphorbol Acetate	111-136	nuclear factor kappa B subunit 1	Homo sapiens	235-243
30518116-5	2018	We concluded that CGA isomers exert anti-inflammatory activity in a mixture of interferon gamma (IFNgamma) and phorbol myristate acetate (PMA)-challenged Caco-2 cells, by decreasing the phosphorylation of p38 cascade and up-regulating NFkappaB signaling.	Tetradecanoylphorbol Acetate	138-141	mitogen-activated protein kinase 14	Homo sapiens	205-208
30518116-5	2018	We concluded that CGA isomers exert anti-inflammatory activity in a mixture of interferon gamma (IFNgamma) and phorbol myristate acetate (PMA)-challenged Caco-2 cells, by decreasing the phosphorylation of p38 cascade and up-regulating NFkappaB signaling.	Tetradecanoylphorbol Acetate	138-141	nuclear factor kappa B subunit 1	Homo sapiens	235-243
29905975-4	2018	Stimulation of immortalized rat cardiomyocytes (H9c2) with phorbol 12-myristate 13-acetate (PMA) resulted in up-regulation of Egr-1 and subsequently of Grk2 mRNA expression, with maximum Grk2 expression (p = 0.008) 5 hr after PMA stimulation and being abolished by actinomycin D, indicating a transcriptional mechanism.	Tetradecanoylphorbol Acetate	59-90	early growth response 1	Rattus norvegicus	126-131
30372888-3	2018	First, we use phorbol-12-myristate-13-acetate (PMA), a phorbol ester, to induce THP-1 cells into macrophages as macrophages model.	Tetradecanoylphorbol Acetate	14-45	GLI family zinc finger 2	Homo sapiens	80-85
30372888-3	2018	First, we use phorbol-12-myristate-13-acetate (PMA), a phorbol ester, to induce THP-1 cells into macrophages as macrophages model.	Tetradecanoylphorbol Acetate	47-50	GLI family zinc finger 2	Homo sapiens	80-85
30320338-5	2018	Among them, Anatase-type TiO2 particles with a primary diameter of 50 nm (A50) were reported to induce interleukin (IL)-1beta production and secretion effectively in phorbol 12-myristate 13-acetate-treated human monocytic leukemia THP-1 cells (THP-1 macrophages).	Tetradecanoylphorbol Acetate	166-197	interleukin 1 beta	Homo sapiens	103-125
30545441-5	2018	Also, Tat-ATOX1 protein markedly inhibited LPS- and TPA-induced inflammatory responses by decreasing cyclooxygenase- 2 (COX-2) and inducible nitric oxide synthase (iNOS) and further inhibited phosphorylation of mitogen activated protein kinases (MAPKs; JNK, ERK and p38) and the nuclear factor-kappaB (NF-kappaB) signaling pathway.	Tetradecanoylphorbol Acetate	52-55	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-118
30545441-5	2018	Also, Tat-ATOX1 protein markedly inhibited LPS- and TPA-induced inflammatory responses by decreasing cyclooxygenase- 2 (COX-2) and inducible nitric oxide synthase (iNOS) and further inhibited phosphorylation of mitogen activated protein kinases (MAPKs; JNK, ERK and p38) and the nuclear factor-kappaB (NF-kappaB) signaling pathway.	Tetradecanoylphorbol Acetate	52-55	prostaglandin-endoperoxide synthase 2	Homo sapiens	120-125
30545441-5	2018	Also, Tat-ATOX1 protein markedly inhibited LPS- and TPA-induced inflammatory responses by decreasing cyclooxygenase- 2 (COX-2) and inducible nitric oxide synthase (iNOS) and further inhibited phosphorylation of mitogen activated protein kinases (MAPKs; JNK, ERK and p38) and the nuclear factor-kappaB (NF-kappaB) signaling pathway.	Tetradecanoylphorbol Acetate	52-55	nitric oxide synthase 2	Homo sapiens	131-162
30545441-5	2018	Also, Tat-ATOX1 protein markedly inhibited LPS- and TPA-induced inflammatory responses by decreasing cyclooxygenase- 2 (COX-2) and inducible nitric oxide synthase (iNOS) and further inhibited phosphorylation of mitogen activated protein kinases (MAPKs; JNK, ERK and p38) and the nuclear factor-kappaB (NF-kappaB) signaling pathway.	Tetradecanoylphorbol Acetate	52-55	nitric oxide synthase 2	Homo sapiens	164-168
30545441-5	2018	Also, Tat-ATOX1 protein markedly inhibited LPS- and TPA-induced inflammatory responses by decreasing cyclooxygenase- 2 (COX-2) and inducible nitric oxide synthase (iNOS) and further inhibited phosphorylation of mitogen activated protein kinases (MAPKs; JNK, ERK and p38) and the nuclear factor-kappaB (NF-kappaB) signaling pathway.	Tetradecanoylphorbol Acetate	52-55	mitogen-activated protein kinase 8	Homo sapiens	253-256
30545441-5	2018	Also, Tat-ATOX1 protein markedly inhibited LPS- and TPA-induced inflammatory responses by decreasing cyclooxygenase- 2 (COX-2) and inducible nitric oxide synthase (iNOS) and further inhibited phosphorylation of mitogen activated protein kinases (MAPKs; JNK, ERK and p38) and the nuclear factor-kappaB (NF-kappaB) signaling pathway.	Tetradecanoylphorbol Acetate	52-55	mitogen-activated protein kinase 14	Homo sapiens	266-269
30545441-5	2018	Also, Tat-ATOX1 protein markedly inhibited LPS- and TPA-induced inflammatory responses by decreasing cyclooxygenase- 2 (COX-2) and inducible nitric oxide synthase (iNOS) and further inhibited phosphorylation of mitogen activated protein kinases (MAPKs; JNK, ERK and p38) and the nuclear factor-kappaB (NF-kappaB) signaling pathway.	Tetradecanoylphorbol Acetate	52-55	nuclear factor kappa B subunit 1	Homo sapiens	279-300
30545441-5	2018	Also, Tat-ATOX1 protein markedly inhibited LPS- and TPA-induced inflammatory responses by decreasing cyclooxygenase- 2 (COX-2) and inducible nitric oxide synthase (iNOS) and further inhibited phosphorylation of mitogen activated protein kinases (MAPKs; JNK, ERK and p38) and the nuclear factor-kappaB (NF-kappaB) signaling pathway.	Tetradecanoylphorbol Acetate	52-55	nuclear factor kappa B subunit 1	Homo sapiens	302-311
30513776-9	2018	Serum IL-8 level was positively correlated with CC status, weight loss, sarcopenia, but was negatively correlated with total psoas area (TPA).	Tetradecanoylphorbol Acetate	137-140	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
30320338-5	2018	Among them, Anatase-type TiO2 particles with a primary diameter of 50 nm (A50) were reported to induce interleukin (IL)-1beta production and secretion effectively in phorbol 12-myristate 13-acetate-treated human monocytic leukemia THP-1 cells (THP-1 macrophages).	Tetradecanoylphorbol Acetate	166-197	GLI family zinc finger 2	Homo sapiens	231-236
30320338-5	2018	Among them, Anatase-type TiO2 particles with a primary diameter of 50 nm (A50) were reported to induce interleukin (IL)-1beta production and secretion effectively in phorbol 12-myristate 13-acetate-treated human monocytic leukemia THP-1 cells (THP-1 macrophages).	Tetradecanoylphorbol Acetate	166-197	GLI family zinc finger 2	Homo sapiens	244-249
30626470-2	2018	Methods THP-1 macrophages were induced from THP-1 cells treated by 100 ng/mL phorbol ester (PMA), and then identified by morphological observation and DiI-oxLDL uptake assay.	Tetradecanoylphorbol Acetate	92-95	GLI family zinc finger 2	Homo sapiens	8-13
30106500-4	2018	Here, we analyzed primary neutrophils from a patient with homozygous JAGN1 mutations with respect to phorbol myristate acetate (PMA)-induced NET formation.	Tetradecanoylphorbol Acetate	101-126	jagunal homolog 1	Homo sapiens	69-74
30106500-4	2018	Here, we analyzed primary neutrophils from a patient with homozygous JAGN1 mutations with respect to phorbol myristate acetate (PMA)-induced NET formation.	Tetradecanoylphorbol Acetate	128-131	jagunal homolog 1	Homo sapiens	69-74
30626470-2	2018	Methods THP-1 macrophages were induced from THP-1 cells treated by 100 ng/mL phorbol ester (PMA), and then identified by morphological observation and DiI-oxLDL uptake assay.	Tetradecanoylphorbol Acetate	92-95	GLI family zinc finger 2	Homo sapiens	44-49
30404828-6	2018	alpha-Synuclein and phorbol 12-myristate 13-acetate (PMA), which is known to enhance vesicle priming mediated by Rab3A, Munc13-1 and Munc18-1, act on the same population of vesicles, but regulate priming independently.	Tetradecanoylphorbol Acetate	20-51	RAB3A, member RAS oncogene family	Rattus norvegicus	113-118
30556022-7	2018	Increased brain levels of IL-1beta, IL-6, and TNF-alpha in the LPS-induced mice were reduced by TPA treatment.	Tetradecanoylphorbol Acetate	96-99	interleukin 1 beta	Mus musculus	26-34
30556022-7	2018	Increased brain levels of IL-1beta, IL-6, and TNF-alpha in the LPS-induced mice were reduced by TPA treatment.	Tetradecanoylphorbol Acetate	96-99	interleukin 6	Mus musculus	36-40
30556022-7	2018	Increased brain levels of IL-1beta, IL-6, and TNF-alpha in the LPS-induced mice were reduced by TPA treatment.	Tetradecanoylphorbol Acetate	96-99	tumor necrosis factor	Mus musculus	46-55
30404828-6	2018	alpha-Synuclein and phorbol 12-myristate 13-acetate (PMA), which is known to enhance vesicle priming mediated by Rab3A, Munc13-1 and Munc18-1, act on the same population of vesicles, but regulate priming independently.	Tetradecanoylphorbol Acetate	53-56	RAB3A, member RAS oncogene family	Rattus norvegicus	113-118
30486830-10	2018	NF-kappaB activity was also reduced in DMBA/TPA-induced skin tissues of IL-32gamma mice.	Tetradecanoylphorbol Acetate	44-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9
30466990-9	2018	CONCLUSION: Orientin inhibits migratory and invasive responses by suppressing MMP-9 and IL-8 expression through mitigation of TPA-induced PKCalpha and ERK activation, as well as the nuclear translocation of AP-1 and STAT3.	Tetradecanoylphorbol Acetate	126-129	signal transducer and activator of transcription 3	Homo sapiens	216-221
30486830-9	2018	Reduced expression of ITGAV and TIMP-1 were identified in DMBA/TPA-induced skin tissues of IL-32gamma mice compared to that in WT mice.	Tetradecanoylphorbol Acetate	63-66	tissue inhibitor of metalloproteinase 1	Mus musculus	32-38
30466979-6	2018	The anti-inflammatory mechanism was explored by measuring the protein and mRNA levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in the ear of the TPA-treated mice.	Tetradecanoylphorbol Acetate	180-183	tumor necrosis factor	Mus musculus	89-116
30455947-12	2018	The aqueous fraction decreased the levels of inflammatory markers interleukin-6, nitric oxide, and matrix metalloproteinase 9 in the mouse mammary SCp2 cells, and the level of interleukin-1beta produced by phorbol-12-myristate-13-acetate-activated THP-1 human monocytic cells.	Tetradecanoylphorbol Acetate	206-237	interleukin 1 beta	Mus musculus	176-193
30466979-6	2018	The anti-inflammatory mechanism was explored by measuring the protein and mRNA levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in the ear of the TPA-treated mice.	Tetradecanoylphorbol Acetate	180-183	tumor necrosis factor	Mus musculus	118-127
30466979-6	2018	The anti-inflammatory mechanism was explored by measuring the protein and mRNA levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in the ear of the TPA-treated mice.	Tetradecanoylphorbol Acetate	180-183	interleukin 1 beta	Mus musculus	130-152
30466979-6	2018	The anti-inflammatory mechanism was explored by measuring the protein and mRNA levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in the ear of the TPA-treated mice.	Tetradecanoylphorbol Acetate	180-183	interleukin 6	Mus musculus	157-161
30466979-9	2018	Moreover, EWSS and EYSS also remarkably inhibited the protein and mRNA levels of TNF-alpha and IL-6 in the ears of TPA-treated mice.	Tetradecanoylphorbol Acetate	115-118	tumor necrosis factor	Mus musculus	81-90
30466979-9	2018	Moreover, EWSS and EYSS also remarkably inhibited the protein and mRNA levels of TNF-alpha and IL-6 in the ears of TPA-treated mice.	Tetradecanoylphorbol Acetate	115-118	interleukin 6	Mus musculus	95-99
30242126-7	2018	In contrast, elevated basal expression of membrane-bound CD14 in phorbol 12-myristate 13-acetate (PMA)-THP-1 cells, primary monocytes, and primary macrophages may promote CD14-mediated endocytosis and be responsible for the preservation of an endotoxin-tolerized state in the presence of IL-27.	Tetradecanoylphorbol Acetate	65-96	GLI family zinc finger 2	Homo sapiens	103-108
30466990-0	2018	Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCalpha/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	132-135	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
30466990-0	2018	Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCalpha/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	132-135	protein kinase C alpha	Homo sapiens	76-84
30466990-0	2018	Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCalpha/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	132-135	mitogen-activated protein kinase 1	Homo sapiens	86-89
30466990-0	2018	Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCalpha/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	132-135	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-94
30466990-0	2018	Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCalpha/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	132-135	signal transducer and activator of transcription 3	Homo sapiens	95-100
30466990-7	2018	TPA-induced membrane translocation of protein kinase C alpha (PKCalpha), phosphorylation of extracellular signal regulated kinase (ERK), and nuclear translocations of activator protein-1 (AP-1) and signal transducer and activator of transcription 3 (STAT3) were downregulated by orientin.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	38-60
30466990-7	2018	TPA-induced membrane translocation of protein kinase C alpha (PKCalpha), phosphorylation of extracellular signal regulated kinase (ERK), and nuclear translocations of activator protein-1 (AP-1) and signal transducer and activator of transcription 3 (STAT3) were downregulated by orientin.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	62-70
30466990-7	2018	TPA-induced membrane translocation of protein kinase C alpha (PKCalpha), phosphorylation of extracellular signal regulated kinase (ERK), and nuclear translocations of activator protein-1 (AP-1) and signal transducer and activator of transcription 3 (STAT3) were downregulated by orientin.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	92-129
30466990-7	2018	TPA-induced membrane translocation of protein kinase C alpha (PKCalpha), phosphorylation of extracellular signal regulated kinase (ERK), and nuclear translocations of activator protein-1 (AP-1) and signal transducer and activator of transcription 3 (STAT3) were downregulated by orientin.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	131-134
30466990-7	2018	TPA-induced membrane translocation of protein kinase C alpha (PKCalpha), phosphorylation of extracellular signal regulated kinase (ERK), and nuclear translocations of activator protein-1 (AP-1) and signal transducer and activator of transcription 3 (STAT3) were downregulated by orientin.	Tetradecanoylphorbol Acetate	0-3	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-186
30466990-7	2018	TPA-induced membrane translocation of protein kinase C alpha (PKCalpha), phosphorylation of extracellular signal regulated kinase (ERK), and nuclear translocations of activator protein-1 (AP-1) and signal transducer and activator of transcription 3 (STAT3) were downregulated by orientin.	Tetradecanoylphorbol Acetate	0-3	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	188-192
30466990-7	2018	TPA-induced membrane translocation of protein kinase C alpha (PKCalpha), phosphorylation of extracellular signal regulated kinase (ERK), and nuclear translocations of activator protein-1 (AP-1) and signal transducer and activator of transcription 3 (STAT3) were downregulated by orientin.	Tetradecanoylphorbol Acetate	0-3	signal transducer and activator of transcription 3	Homo sapiens	198-248
30466990-7	2018	TPA-induced membrane translocation of protein kinase C alpha (PKCalpha), phosphorylation of extracellular signal regulated kinase (ERK), and nuclear translocations of activator protein-1 (AP-1) and signal transducer and activator of transcription 3 (STAT3) were downregulated by orientin.	Tetradecanoylphorbol Acetate	0-3	signal transducer and activator of transcription 3	Homo sapiens	250-255
30466990-9	2018	CONCLUSION: Orientin inhibits migratory and invasive responses by suppressing MMP-9 and IL-8 expression through mitigation of TPA-induced PKCalpha and ERK activation, as well as the nuclear translocation of AP-1 and STAT3.	Tetradecanoylphorbol Acetate	126-129	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
30466990-9	2018	CONCLUSION: Orientin inhibits migratory and invasive responses by suppressing MMP-9 and IL-8 expression through mitigation of TPA-induced PKCalpha and ERK activation, as well as the nuclear translocation of AP-1 and STAT3.	Tetradecanoylphorbol Acetate	126-129	protein kinase C alpha	Homo sapiens	138-146
30466990-9	2018	CONCLUSION: Orientin inhibits migratory and invasive responses by suppressing MMP-9 and IL-8 expression through mitigation of TPA-induced PKCalpha and ERK activation, as well as the nuclear translocation of AP-1 and STAT3.	Tetradecanoylphorbol Acetate	126-129	mitogen-activated protein kinase 1	Homo sapiens	151-154
30389973-2	2018	Here, we used phorbol-12-myristate-13-acetate (PMA) as an inducer for Thy-1 expression to investigate molecular mechanisms underlying Thy-1 up-regulation.	Tetradecanoylphorbol Acetate	14-45	Thy-1 cell surface antigen	Danio rerio	70-75
30389973-2	2018	Here, we used phorbol-12-myristate-13-acetate (PMA) as an inducer for Thy-1 expression to investigate molecular mechanisms underlying Thy-1 up-regulation.	Tetradecanoylphorbol Acetate	14-45	Thy-1 cell surface antigen	Danio rerio	134-139
30389973-2	2018	Here, we used phorbol-12-myristate-13-acetate (PMA) as an inducer for Thy-1 expression to investigate molecular mechanisms underlying Thy-1 up-regulation.	Tetradecanoylphorbol Acetate	47-50	Thy-1 cell surface antigen	Danio rerio	70-75
30389973-3	2018	Our data showed that increased levels of Thy-1 mRNA and protein in endothelial cells were observed at 14-18 hours and 20-28 hours after PMA treatment, respectively.	Tetradecanoylphorbol Acetate	136-139	Thy-1 cell surface antigen	Danio rerio	41-46
30389973-4	2018	Treatment with PMA for 32 hours induced Thy-1 up-regulation and inhibited capillary-like tube formation and endothelial cell migration.	Tetradecanoylphorbol Acetate	15-18	Thy-1 cell surface antigen	Danio rerio	40-45
30389973-6	2018	Moreover, pre-treatment with Bay 61-3606 (a Syk inhibitor) or Bay 11-7082 (a NF-kappaB inhibitor) abolished the PMA-induced Thy-1 up-regulation and migration inhibition in endothelial cells.	Tetradecanoylphorbol Acetate	112-115	Thy-1 cell surface antigen	Danio rerio	124-129
30081297-2	2018	In this study, we demonstrate that treatment with Calcimycin in PMA (Phorbol 12-myristate 13-acetate) differentiated THP-1 (dTHP-1) cells significantly induced interleukin (IL)-12 mRNA expression and its release.	Tetradecanoylphorbol Acetate	64-67	GLI family zinc finger 2	Homo sapiens	117-122
30081297-2	2018	In this study, we demonstrate that treatment with Calcimycin in PMA (Phorbol 12-myristate 13-acetate) differentiated THP-1 (dTHP-1) cells significantly induced interleukin (IL)-12 mRNA expression and its release.	Tetradecanoylphorbol Acetate	69-100	GLI family zinc finger 2	Homo sapiens	117-122
30402027-5	2018	To elucidate the action mechanism of tussilagone, effect of tussilagone on PMA-induced NF-kappaB signaling pathway was investigated by western blot analysis.	Tetradecanoylphorbol Acetate	75-78	nuclear factor kappa B subunit 1	Homo sapiens	87-96
30536349-2	2018	MATERIALS AND METHODS: THP-1 cells were adopted for research, and phorbol-12-myristate-13-acetate (PMA) was utilized to induce THP-1 cells to be transformed into macrophages, with Ang II as a stimulating factor and telmisartan as a therapeutic drug.	Tetradecanoylphorbol Acetate	66-97	angiotensinogen	Homo sapiens	180-186
30536349-2	2018	MATERIALS AND METHODS: THP-1 cells were adopted for research, and phorbol-12-myristate-13-acetate (PMA) was utilized to induce THP-1 cells to be transformed into macrophages, with Ang II as a stimulating factor and telmisartan as a therapeutic drug.	Tetradecanoylphorbol Acetate	99-102	angiotensinogen	Homo sapiens	180-186
30133131-6	2018	TPA-induced membrane translocation of PKCalpha, phosphorylation of JNK, and the nuclear translocations of AP-1 and NF-kappaB were downregulated by mLU8C-PU in MCF-7 cells.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	38-46
30133131-6	2018	TPA-induced membrane translocation of PKCalpha, phosphorylation of JNK, and the nuclear translocations of AP-1 and NF-kappaB were downregulated by mLU8C-PU in MCF-7 cells.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	67-70
30133131-6	2018	TPA-induced membrane translocation of PKCalpha, phosphorylation of JNK, and the nuclear translocations of AP-1 and NF-kappaB were downregulated by mLU8C-PU in MCF-7 cells.	Tetradecanoylphorbol Acetate	0-3	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-110
30133131-6	2018	TPA-induced membrane translocation of PKCalpha, phosphorylation of JNK, and the nuclear translocations of AP-1 and NF-kappaB were downregulated by mLU8C-PU in MCF-7 cells.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	115-124
30133131-8	2018	These results indicate that mLU8C-PU inhibits migratory and invasive responses in MCF-7 breast cancer cells by suppressing MMP-9 and IL-8 expression through mitigating TPA-induced PKCalpha, JNK activation, and the nuclear translocation of AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	168-171	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
30133131-8	2018	These results indicate that mLU8C-PU inhibits migratory and invasive responses in MCF-7 breast cancer cells by suppressing MMP-9 and IL-8 expression through mitigating TPA-induced PKCalpha, JNK activation, and the nuclear translocation of AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	168-171	protein kinase C alpha	Homo sapiens	180-188
30133131-8	2018	These results indicate that mLU8C-PU inhibits migratory and invasive responses in MCF-7 breast cancer cells by suppressing MMP-9 and IL-8 expression through mitigating TPA-induced PKCalpha, JNK activation, and the nuclear translocation of AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	168-171	mitogen-activated protein kinase 8	Homo sapiens	190-193
30133131-8	2018	These results indicate that mLU8C-PU inhibits migratory and invasive responses in MCF-7 breast cancer cells by suppressing MMP-9 and IL-8 expression through mitigating TPA-induced PKCalpha, JNK activation, and the nuclear translocation of AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	168-171	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	239-243
30133131-8	2018	These results indicate that mLU8C-PU inhibits migratory and invasive responses in MCF-7 breast cancer cells by suppressing MMP-9 and IL-8 expression through mitigating TPA-induced PKCalpha, JNK activation, and the nuclear translocation of AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	168-171	nuclear factor kappa B subunit 1	Homo sapiens	248-257
30226556-9	2018	The in vitro experiments demonstrated that NGE reduced the phorbol 12-myristate 13-acetate + ionomycin-induced expression of pro-inflammatory cytokines interleukin (IL)-4, IL-13, tumor necrosis factor-alpha, and IL-6 in HMC-1 cells.	Tetradecanoylphorbol Acetate	59-90	interleukin 13	Homo sapiens	172-206
30226556-9	2018	The in vitro experiments demonstrated that NGE reduced the phorbol 12-myristate 13-acetate + ionomycin-induced expression of pro-inflammatory cytokines interleukin (IL)-4, IL-13, tumor necrosis factor-alpha, and IL-6 in HMC-1 cells.	Tetradecanoylphorbol Acetate	59-90	interleukin 6	Homo sapiens	212-216
29790117-3	2018	This hypothesis was tested in human acute monocytic leukemia cells (THP-1), which were differentiated into macrophages with 2-O-tetradecanoylphorbol-13-acetate (TPA) and further activated with LPS for 24 h. Monocytes, macrophages, and AcM were transfected with a negative control, or mimics for miR-155-3p and miR-let-7b-5p.	Tetradecanoylphorbol Acetate	161-164	GLI family zinc finger 2	Homo sapiens	68-73
30402027-7	2018	Tussilagone inhibited PMA-induced activation (phosphorylation) of inhibitory kappa B kinase (IKK), and thus phosphorylation and degradation of inhibitory kappa Ba (IkappaBalpha).	Tetradecanoylphorbol Acetate	22-25	NFKB inhibitor alpha	Homo sapiens	164-176
30402027-8	2018	Tussilagone inhibited PMA-induced phosphorylation and nuclear translocation of nuclear factor kappa B (NF-kappaB) p65.	Tetradecanoylphorbol Acetate	22-25	nuclear factor kappa B subunit 1	Homo sapiens	79-101
30402027-8	2018	Tussilagone inhibited PMA-induced phosphorylation and nuclear translocation of nuclear factor kappa B (NF-kappaB) p65.	Tetradecanoylphorbol Acetate	22-25	nuclear factor kappa B subunit 1	Homo sapiens	103-112
30426024-7	2018	Secreted production of IFN-gamma stimulated via CD3 decreased by CH exposure at 30 mug/ml, although the percentage of IFN-gamma + cells induced by PMA/ionomycin did not decrease.	Tetradecanoylphorbol Acetate	147-150	interferon gamma	Homo sapiens	118-127
30498366-7	2018	This inhibitory effect was associated with the inhibition of TPA-induced upregulation of proinflammatory cytokines IL-1beta, TNF-alpha, and COX-2.	Tetradecanoylphorbol Acetate	61-64	interleukin 1 beta	Mus musculus	115-123
30498366-7	2018	This inhibitory effect was associated with the inhibition of TPA-induced upregulation of proinflammatory cytokines IL-1beta, TNF-alpha, and COX-2.	Tetradecanoylphorbol Acetate	61-64	tumor necrosis factor	Mus musculus	125-134
30498366-8	2018	WU-FA-01 significantly suppressed the expression levels of p65, IkappaB-alpha, and p-IkappaB-alpha in the TPA-induced mouse ear model.	Tetradecanoylphorbol Acetate	106-109	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	85-98
29923144-6	2018	RESULTS: We found that treatment of HT-29 and Caco-2 cells (differentiated and low metastatic) with 12-O-tetradecanoyl phorbol-13-acetate (TPA; a tumor promoter) suppressed E-cadherin and beta-catenin expression at both the mRNA and protein levels and, in addition, enhanced cell migration.	Tetradecanoylphorbol Acetate	100-137	cadherin 1	Homo sapiens	173-183
29966967-3	2018	THP-1 monocytes were differentiated to macrophages using phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	57-88	GLI family zinc finger 2	Homo sapiens	0-5
30353147-4	2018	Using our TPA model, we have demonstrated that spontaneous diastolic depolarization observed in atrial myocytes with TBX5-deletion can be explained by altered intracellular calcium handling and suppression of inward-rectifier potassium current (IK1).	Tetradecanoylphorbol Acetate	10-13	T-box transcription factor 5	Homo sapiens	117-121
30076961-9	2018	Unexpectedly, FSAP-treated fibrinogen or plasma exhibited a significantly faster tPA-driven lysis, which correlated exclusively with cleavage of fibrinogen and not with activation of plasminogen activators.	Tetradecanoylphorbol Acetate	81-84	fibrinogen beta chain	Homo sapiens	27-37
30076961-9	2018	Unexpectedly, FSAP-treated fibrinogen or plasma exhibited a significantly faster tPA-driven lysis, which correlated exclusively with cleavage of fibrinogen and not with activation of plasminogen activators.	Tetradecanoylphorbol Acetate	81-84	fibrinogen beta chain	Homo sapiens	145-155
29923144-6	2018	RESULTS: We found that treatment of HT-29 and Caco-2 cells (differentiated and low metastatic) with 12-O-tetradecanoyl phorbol-13-acetate (TPA; a tumor promoter) suppressed E-cadherin and beta-catenin expression at both the mRNA and protein levels and, in addition, enhanced cell migration.	Tetradecanoylphorbol Acetate	139-142	cadherin 1	Homo sapiens	173-183
29704820-5	2018	METHODS: We used human lung fibroblasts and THP-1 macrophages differentiated from THP-1 cells using phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	100-131	GLI family zinc finger 2	Homo sapiens	82-87
30465338-2	2018	METHODS: THP-1 cells (a human monocytic cell line derived from an acute monocytic leukemia patient) were induced to differentiate THP-1 macrophages by phorbol-12-myristate-13-acetate and were injected with 0 (blank control), 0.5, or 1.0 mug mL-1 Pg-LPS.	Tetradecanoylphorbol Acetate	151-182	GLI family zinc finger 2	Homo sapiens	9-14
30098331-6	2018	We confirm that PMA-induced PKC activation causes ErbB2 internalization, but while the Hsp90 inhibitor 17-AAG induced ErbB2 degradation, PMA had no such effect.	Tetradecanoylphorbol Acetate	16-19	proline rich transmembrane protein 2	Homo sapiens	28-31
30098331-6	2018	We confirm that PMA-induced PKC activation causes ErbB2 internalization, but while the Hsp90 inhibitor 17-AAG induced ErbB2 degradation, PMA had no such effect.	Tetradecanoylphorbol Acetate	16-19	erb-b2 receptor tyrosine kinase 2	Homo sapiens	50-55
30098331-7	2018	When combined with 17-AAG, PMA had additive effect on ErbB2 internalization indicating that Hsp90 inhibition and PKC activation induce internalization by alternative mechanisms.	Tetradecanoylphorbol Acetate	27-30	erb-b2 receptor tyrosine kinase 2	Homo sapiens	54-59
30098331-7	2018	When combined with 17-AAG, PMA had additive effect on ErbB2 internalization indicating that Hsp90 inhibition and PKC activation induce internalization by alternative mechanisms.	Tetradecanoylphorbol Acetate	27-30	proline rich transmembrane protein 2	Homo sapiens	113-116
30158075-6	2018	Here we demonstrate that when the human macrophage cell line THP-1 are cultured in FACS tubes with phorbol myristate acetate added, they undergo differentiation into macrophages, assessed morphologically and by autofluorescence expression, in a similar manner to those cultured in tissue culture dishes.	Tetradecanoylphorbol Acetate	99-124	GLI family zinc finger 2	Homo sapiens	61-66
30139243-8	2018	Mn2+ has been shown to enter cellsthrough similar mechanisms as Ca2+ but quenches fura-2 fluorescence at all excitation wavelengths.Captopril (3000 muM)-induced Mn2+ influx indirectly suggested that captopril evoked Ca2+ entry.Captopril-induced Ca2+ entry was inhibited by 15% by a protein kinase C (PKC) activator (phorbol12-myristate 13 acetate, PMA) and an inhibitor (GF109203X) and three inhibitors of store-operatedCa2+ channels: nifedipine, econazole and SKF96365.	Tetradecanoylphorbol Acetate	316-346	latexin	Homo sapiens	148-151
30208917-8	2018	However, whereas phorbol 12-myristate 13-acetate/ionomycin stimulation induced the production of both interferon-gamma and IL-17 by breast duct MAIT cells, bacterially exposed breast carcinoma cells elicited a strongly IL-17-biased response.	Tetradecanoylphorbol Acetate	17-48	interferon gamma	Homo sapiens	102-118
29933063-7	2018	We show that cells encapsulated in polymers of cellulose sulphate are able to release cytokines such as interleukin-2 (IL-2) in a stimulated fashion e.g. using phorbol 12-myristate 13-acetate (PMA) plus ionomycin.	Tetradecanoylphorbol Acetate	160-191	interleukin 2	Homo sapiens	104-117
29933063-7	2018	We show that cells encapsulated in polymers of cellulose sulphate are able to release cytokines such as interleukin-2 (IL-2) in a stimulated fashion e.g. using phorbol 12-myristate 13-acetate (PMA) plus ionomycin.	Tetradecanoylphorbol Acetate	160-191	interleukin 2	Homo sapiens	119-123
29933063-7	2018	We show that cells encapsulated in polymers of cellulose sulphate are able to release cytokines such as interleukin-2 (IL-2) in a stimulated fashion e.g. using phorbol 12-myristate 13-acetate (PMA) plus ionomycin.	Tetradecanoylphorbol Acetate	193-196	interleukin 2	Homo sapiens	104-117
29933063-7	2018	We show that cells encapsulated in polymers of cellulose sulphate are able to release cytokines such as interleukin-2 (IL-2) in a stimulated fashion e.g. using phorbol 12-myristate 13-acetate (PMA) plus ionomycin.	Tetradecanoylphorbol Acetate	193-196	interleukin 2	Homo sapiens	119-123
29883943-6	2018	To confirm the positive effects on inflammation, TPA (12-O-tetradecanoylphorbol-13-acetate) induced inflammation measured by mouse ear thickness and biopsy punch weight and TPA-induced iNOS, COX-2 mRNA and protein expression were remarkably suppressed by 50 and 100 mg/kg ZPE-LR oral-administration.	Tetradecanoylphorbol Acetate	49-52	nitric oxide synthase 2, inducible	Mus musculus	185-189
29883943-6	2018	To confirm the positive effects on inflammation, TPA (12-O-tetradecanoylphorbol-13-acetate) induced inflammation measured by mouse ear thickness and biopsy punch weight and TPA-induced iNOS, COX-2 mRNA and protein expression were remarkably suppressed by 50 and 100 mg/kg ZPE-LR oral-administration.	Tetradecanoylphorbol Acetate	173-176	nitric oxide synthase 2, inducible	Mus musculus	185-189
29883943-7	2018	In addition, TPA-induced iNOS, COX-2 mRNA level and protein expression were reduced.	Tetradecanoylphorbol Acetate	13-16	nitric oxide synthase 2, inducible	Mus musculus	25-29
30015874-0	2018	P2X7 receptor regulates EMMPRIN and MMP-9 expression through AMPK/MAPK signaling in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	84-87	purinergic receptor P2X 7	Homo sapiens	0-13
30226259-5	2018	The TPA coefficient of the MoS2 nanofilms with increased crystallinity is improved to (4.3 +- 0.5) x 102 cm GW-1 on increasing the crystallinity of MoS2 films, over four times larger than that of their counterpart with relatively low crystallinity.	Tetradecanoylphorbol Acetate	4-7	trinucleotide repeat containing adaptor 6A	Homo sapiens	108-112
29798705-6	2018	In this work, the ability of L. fermentum UCO-979C to modulate immune response in AGS cells and PMA phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 (human monocytic leukaemia) macrophages in response to H. pylori infection was evaluated.	Tetradecanoylphorbol Acetate	100-131	GLI family zinc finger 2	Homo sapiens	153-158
29798705-6	2018	In this work, the ability of L. fermentum UCO-979C to modulate immune response in AGS cells and PMA phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 (human monocytic leukaemia) macrophages in response to H. pylori infection was evaluated.	Tetradecanoylphorbol Acetate	96-99	GLI family zinc finger 2	Homo sapiens	153-158
30581695-1	2018	Three diazafluorene derivatives triphenylamine (TPA)(PDAF) n (n = 1, 2, 3) serving as small molecular elements are designed and synthesized via concentrated sulfuric acid mediated Friedel-Crafts reaction.	Tetradecanoylphorbol Acetate	48-51	estrogen receptor binding site associated antigen 9	Homo sapiens	53-57
30581695-2	2018	With highly nonplanar topological configuration, TPA(PDAF)3 shows weaker intermolecular interaction in the solid states and thus exhibits single nanomolecular behavior, which is crucial for charge stored and retained in an organic field-effect transistor (OFET) memory device.	Tetradecanoylphorbol Acetate	49-52	estrogen receptor binding site associated antigen 9	Homo sapiens	53-57
30581695-5	2018	The pentacene-based OFET memory device with solution-processing TPA(PDAF)3 shows a good hole-trapping ability, high hole trapping density (4.55 x 1012 cm-2), fast trapping speed (&lt;20 ms), a large memory window (89 V), and a tunable ambipolar memory behavior.	Tetradecanoylphorbol Acetate	64-67	estrogen receptor binding site associated antigen 9	Homo sapiens	68-72
30139243-8	2018	Mn2+ has been shown to enter cellsthrough similar mechanisms as Ca2+ but quenches fura-2 fluorescence at all excitation wavelengths.Captopril (3000 muM)-induced Mn2+ influx indirectly suggested that captopril evoked Ca2+ entry.Captopril-induced Ca2+ entry was inhibited by 15% by a protein kinase C (PKC) activator (phorbol12-myristate 13 acetate, PMA) and an inhibitor (GF109203X) and three inhibitors of store-operatedCa2+ channels: nifedipine, econazole and SKF96365.	Tetradecanoylphorbol Acetate	348-351	latexin	Homo sapiens	148-151
29398679-5	2018	METHODS: THP-1 monocytes, a human leukemic cell line, were stimulated with 50 ng/mL of phorbol-12-myristate-13-acetate (PMA) 1 h after pretreatment with 10 muM azelnidipine or dimethyl sulfoxide (DMSO), and harvested.	Tetradecanoylphorbol Acetate	87-118	GLI family zinc finger 2	Homo sapiens	9-14
30157903-3	2018	METHODS: Human THP-1 monocytes were induced to differentiate into M2 macrophages through treatments with IL-4, IL-13, and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	122-147	GLI family zinc finger 2	Homo sapiens	15-20
30157903-3	2018	METHODS: Human THP-1 monocytes were induced to differentiate into M2 macrophages through treatments with IL-4, IL-13, and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	149-152	GLI family zinc finger 2	Homo sapiens	15-20
30142192-0	2018	Deacetylase activity-independent transcriptional activation by HDAC2 during TPA-induced HL-60 cell differentiation.	Tetradecanoylphorbol Acetate	76-79	histone deacetylase 2	Homo sapiens	63-68
30142192-7	2018	Taken together, these data elucidated the specific-chromatin status during HL-60 cell differentiation following TPA exposure and suggested that HDAC2 can activate transcription of certain genes through interactions with PAX5 in a deacetylase activity-independent pathway.	Tetradecanoylphorbol Acetate	112-115	histone deacetylase 2	Homo sapiens	144-149
30537802-7	2018	In CD4+ T cells treated with PMA+MLIF, the expression levels of IFN-gamma, TNF-alpha and IL-4 were strongly inhibited (p&lt;0.001, p&lt;0.001 and p&lt;0.0094), compared to PMA treatment alone, for both, rhinitis and asthma.	Tetradecanoylphorbol Acetate	29-32	interferon gamma	Homo sapiens	64-73
30537802-7	2018	In CD4+ T cells treated with PMA+MLIF, the expression levels of IFN-gamma, TNF-alpha and IL-4 were strongly inhibited (p&lt;0.001, p&lt;0.001 and p&lt;0.0094), compared to PMA treatment alone, for both, rhinitis and asthma.	Tetradecanoylphorbol Acetate	29-32	tumor necrosis factor	Homo sapiens	75-84
30537802-7	2018	In CD4+ T cells treated with PMA+MLIF, the expression levels of IFN-gamma, TNF-alpha and IL-4 were strongly inhibited (p&lt;0.001, p&lt;0.001 and p&lt;0.0094), compared to PMA treatment alone, for both, rhinitis and asthma.	Tetradecanoylphorbol Acetate	29-32	interleukin 4	Homo sapiens	89-93
30537802-7	2018	In CD4+ T cells treated with PMA+MLIF, the expression levels of IFN-gamma, TNF-alpha and IL-4 were strongly inhibited (p&lt;0.001, p&lt;0.001 and p&lt;0.0094), compared to PMA treatment alone, for both, rhinitis and asthma.	Tetradecanoylphorbol Acetate	172-175	interferon gamma	Homo sapiens	64-73
30537802-7	2018	In CD4+ T cells treated with PMA+MLIF, the expression levels of IFN-gamma, TNF-alpha and IL-4 were strongly inhibited (p&lt;0.001, p&lt;0.001 and p&lt;0.0094), compared to PMA treatment alone, for both, rhinitis and asthma.	Tetradecanoylphorbol Acetate	172-175	tumor necrosis factor	Homo sapiens	75-84
30537802-7	2018	In CD4+ T cells treated with PMA+MLIF, the expression levels of IFN-gamma, TNF-alpha and IL-4 were strongly inhibited (p&lt;0.001, p&lt;0.001 and p&lt;0.0094), compared to PMA treatment alone, for both, rhinitis and asthma.	Tetradecanoylphorbol Acetate	172-175	interleukin 4	Homo sapiens	89-93
30058806-6	2018	The expression levels of p-ERK1/2 and p-p38 mitogen-activated protein kinase (MAPK) in the TPA group were 5.3, 4.8, and 5.7 but downregulated to 2.7, 2.9, and 2.3 in the Nob group and 2.4, 2.7, and 1.2 in the 5-HPMF group, respectively ( p &lt;= 0.05).	Tetradecanoylphorbol Acetate	91-94	mitogen-activated protein kinase 1	Mus musculus	78-82
30154906-6	2018	Furthermore, KJS018A diminished the effect of PMA, an inflammatory inducer via IL-6/STAT3/Cox-2 pathway.	Tetradecanoylphorbol Acetate	46-49	interleukin 6	Homo sapiens	79-83
30154906-6	2018	Furthermore, KJS018A diminished the effect of PMA, an inflammatory inducer via IL-6/STAT3/Cox-2 pathway.	Tetradecanoylphorbol Acetate	46-49	signal transducer and activator of transcription 3	Homo sapiens	84-89
30154906-6	2018	Furthermore, KJS018A diminished the effect of PMA, an inflammatory inducer via IL-6/STAT3/Cox-2 pathway.	Tetradecanoylphorbol Acetate	46-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
29398679-5	2018	METHODS: THP-1 monocytes, a human leukemic cell line, were stimulated with 50 ng/mL of phorbol-12-myristate-13-acetate (PMA) 1 h after pretreatment with 10 muM azelnidipine or dimethyl sulfoxide (DMSO), and harvested.	Tetradecanoylphorbol Acetate	120-123	GLI family zinc finger 2	Homo sapiens	9-14
30073169-10	2018	In agreement, 80 nM PMA (a PKC activator) mimicked the effect of LPS on the activation of the MEK/ERK/TSC2/mTORC1/S6K pathway, monocyte adhesion to ECV cells and actin cytoskeleton rearrangement.	Tetradecanoylphorbol Acetate	20-23	mitogen-activated protein kinase kinase 7	Homo sapiens	94-97
29859810-5	2018	PA family of proteins are classified into two types namely: uPA and tissue type plasminogen activator (tPA).	Tetradecanoylphorbol Acetate	103-106	plasminogen activator, tissue type	Homo sapiens	68-101
30060484-3	2018	In this study, the anti-inflammatory effects of DA on the MAP kinase and NFkappaB signaling pathways and the expression of pro-inflammatory cytokines were investigated in phorbol 12-myristate 13-acetate (PMA)-activated human promyelocytic leukemia (HL-60) and lipopolysaccharide (LPS)-stimulated macrophage (Raw 264.7) cell lines.	Tetradecanoylphorbol Acetate	204-207	nuclear factor kappa B subunit 1	Homo sapiens	73-81
30060484-3	2018	In this study, the anti-inflammatory effects of DA on the MAP kinase and NFkappaB signaling pathways and the expression of pro-inflammatory cytokines were investigated in phorbol 12-myristate 13-acetate (PMA)-activated human promyelocytic leukemia (HL-60) and lipopolysaccharide (LPS)-stimulated macrophage (Raw 264.7) cell lines.	Tetradecanoylphorbol Acetate	204-207	toll-like receptor 4	Mus musculus	280-283
30288224-0	2018	Glycyrrhizic acid from licorice down-regulates inflammatory responses via blocking MAPK and PI3K/Akt-dependent NF-kappaB signalling pathways in TPA-induced skin inflammation.	Tetradecanoylphorbol Acetate	144-147	thymoma viral proto-oncogene 1	Mus musculus	97-100
30288224-0	2018	Glycyrrhizic acid from licorice down-regulates inflammatory responses via blocking MAPK and PI3K/Akt-dependent NF-kappaB signalling pathways in TPA-induced skin inflammation.	Tetradecanoylphorbol Acetate	144-147	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	111-120
30288224-4	2018	It was indicated that GA, applied topically onto mouse ears, effectively inhibited the TPA-mediated expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner, respectively.	Tetradecanoylphorbol Acetate	87-90	nitric oxide synthase 2, inducible	Mus musculus	115-146
30288224-4	2018	It was indicated that GA, applied topically onto mouse ears, effectively inhibited the TPA-mediated expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner, respectively.	Tetradecanoylphorbol Acetate	87-90	nitric oxide synthase 2, inducible	Mus musculus	148-152
30288224-5	2018	Mechanistic investigations demonstrated that GA down-regulated the expressions of IkappaBalpha and p65 and blocked the phosphorylation of IkappaBalpha and p65 in TPA-induced mouse skin.	Tetradecanoylphorbol Acetate	162-165	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	138-150
30140696-6	2018	Stigmasterol controlled inflammatory features such as ear skin oedema and neutrophilia and also reduced serum levels of TNFalpha induced by topical application of TPA.	Tetradecanoylphorbol Acetate	163-166	tumor necrosis factor	Homo sapiens	120-128
30288224-6	2018	Moreover, GA significantly inhibited the TPA-mediated activation of extracellular signal-regulated kinase (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K)/Akt, which are upstream of nuclear factor-kB (NF-kappaB).	Tetradecanoylphorbol Acetate	41-44	thymoma viral proto-oncogene 1	Mus musculus	202-205
30288224-6	2018	Moreover, GA significantly inhibited the TPA-mediated activation of extracellular signal-regulated kinase (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K)/Akt, which are upstream of nuclear factor-kB (NF-kappaB).	Tetradecanoylphorbol Acetate	41-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	248-257
30073169-10	2018	In agreement, 80 nM PMA (a PKC activator) mimicked the effect of LPS on the activation of the MEK/ERK/TSC2/mTORC1/S6K pathway, monocyte adhesion to ECV cells and actin cytoskeleton rearrangement.	Tetradecanoylphorbol Acetate	20-23	mitogen-activated protein kinase 1	Homo sapiens	98-101
29970564-3	2018	MATERIALS AND METHODS: THP-1 macrophages were induced by 12-O-tetradecanoyl-13-acetate (TPA).	Tetradecanoylphorbol Acetate	88-91	GLI family zinc finger 2	Homo sapiens	23-28
30061889-6	2018	Moreover, CD49dhigh CD4+ T cells showed a Th1-like memory phenotype, characterized by high expression of CD44 and CXCR3; low expression of CD62L and CCR7; rapid production of IFN-gamma, tumor necrosis factor-alpha, and IL-2 upon stimulation with phorbol myristate acetate and ionomycin; and rapid proliferation upon stimulation with anti-CD3 and anti-CD28 antibodies.	Tetradecanoylphorbol Acetate	246-271	CD4 molecule	Homo sapiens	10-13
29842805-6	2018	The present results showed that the MEF2A and MEF2D function as mediators for TPA-elicited SOD3 expression by interacting with HDAC or p300.	Tetradecanoylphorbol Acetate	78-81	superoxide dismutase 3	Homo sapiens	91-95
29842805-2	2018	We previously demonstrated that histone acetylation is involved in 12-O-tetra-decanoylphorbol-13-acetate (TPA)-elicited SOD3 expression in human monocytic THP-1 cells; however, the molecular mechanisms responsible for its expression have not yet been elucidated in detail.	Tetradecanoylphorbol Acetate	106-109	superoxide dismutase 3	Homo sapiens	120-124
29842805-4	2018	On the other hand, the dissociation of HDAC1 from the SOD3 promoter region and the enrichment of p300, a histone acetyltransferase (HAT), within that region were observed in TPA-induced THP-1 cells.	Tetradecanoylphorbol Acetate	174-177	histone deacetylase 1	Homo sapiens	39-44
29842805-4	2018	On the other hand, the dissociation of HDAC1 from the SOD3 promoter region and the enrichment of p300, a histone acetyltransferase (HAT), within that region were observed in TPA-induced THP-1 cells.	Tetradecanoylphorbol Acetate	174-177	superoxide dismutase 3	Homo sapiens	54-58
29601810-10	2018	On the contrary, phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of Src, AKT, P38, PKC and membrane localization of p47ph x and P40ph x remained unaffected.	Tetradecanoylphorbol Acetate	17-48	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	82-85
29747125-9	2018	Further, the ELISA assay suggested a pronounced increase of TNF-alpha production by cultured splenocytes with PMA/ionomycin re-stimulation but no increase in its presence in spleen tissue upon DSS challenge.	Tetradecanoylphorbol Acetate	110-113	tumor necrosis factor	Mus musculus	60-69
29601810-10	2018	On the contrary, phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of Src, AKT, P38, PKC and membrane localization of p47ph x and P40ph x remained unaffected.	Tetradecanoylphorbol Acetate	17-48	AKT serine/threonine kinase 1	Homo sapiens	87-90
29601810-10	2018	On the contrary, phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of Src, AKT, P38, PKC and membrane localization of p47ph x and P40ph x remained unaffected.	Tetradecanoylphorbol Acetate	17-48	mitogen-activated protein kinase 14	Homo sapiens	92-95
29601810-10	2018	On the contrary, phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of Src, AKT, P38, PKC and membrane localization of p47ph x and P40ph x remained unaffected.	Tetradecanoylphorbol Acetate	17-48	proline rich transmembrane protein 2	Homo sapiens	97-100
29601810-10	2018	On the contrary, phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of Src, AKT, P38, PKC and membrane localization of p47ph x and P40ph x remained unaffected.	Tetradecanoylphorbol Acetate	50-53	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	82-85
29601810-10	2018	On the contrary, phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of Src, AKT, P38, PKC and membrane localization of p47ph x and P40ph x remained unaffected.	Tetradecanoylphorbol Acetate	50-53	AKT serine/threonine kinase 1	Homo sapiens	87-90
29601810-10	2018	On the contrary, phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of Src, AKT, P38, PKC and membrane localization of p47ph x and P40ph x remained unaffected.	Tetradecanoylphorbol Acetate	50-53	mitogen-activated protein kinase 14	Homo sapiens	92-95
29601810-10	2018	On the contrary, phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of Src, AKT, P38, PKC and membrane localization of p47ph x and P40ph x remained unaffected.	Tetradecanoylphorbol Acetate	50-53	proline rich transmembrane protein 2	Homo sapiens	97-100
29477140-3	2018	We observed that, upon phorbol 12-myristate 13-acetate (PMA) treatment, THP-1 cells differentiated into monocytes by down-regulating Aurora kinase A (AURKA), resulting in a reduction in H3S10 phosphorylation.	Tetradecanoylphorbol Acetate	23-54	GLI family zinc finger 2	Homo sapiens	72-77
29656208-3	2018	M0 macrophages derived from the phorbol-12-myristate-13-acetate-induced human acute monocytic leukemia cell line THP-1 were cultured with T. pallidum.	Tetradecanoylphorbol Acetate	32-63	GLI family zinc finger 2	Homo sapiens	113-118
29660338-7	2018	It was found that TPA induced interaction between the transcriptional factors Sp1 and P53 producing Sp1-p53 complex which strongly interacted with c-Jun only after short exposure to TPA.	Tetradecanoylphorbol Acetate	18-21	tumor protein p53	Homo sapiens	86-89
29660338-7	2018	It was found that TPA induced interaction between the transcriptional factors Sp1 and P53 producing Sp1-p53 complex which strongly interacted with c-Jun only after short exposure to TPA.	Tetradecanoylphorbol Acetate	18-21	tumor protein p53	Homo sapiens	104-107
29660338-7	2018	It was found that TPA induced interaction between the transcriptional factors Sp1 and P53 producing Sp1-p53 complex which strongly interacted with c-Jun only after short exposure to TPA.	Tetradecanoylphorbol Acetate	182-185	tumor protein p53	Homo sapiens	86-89
29660338-7	2018	It was found that TPA induced interaction between the transcriptional factors Sp1 and P53 producing Sp1-p53 complex which strongly interacted with c-Jun only after short exposure to TPA.	Tetradecanoylphorbol Acetate	182-185	tumor protein p53	Homo sapiens	104-107
29660338-8	2018	In addition, TPA treatment highly induced the expression of CREB which attached to the Sp1-p53 complex mainly after a long exposure to TPA.	Tetradecanoylphorbol Acetate	13-16	tumor protein p53	Homo sapiens	91-94
29660338-8	2018	In addition, TPA treatment highly induced the expression of CREB which attached to the Sp1-p53 complex mainly after a long exposure to TPA.	Tetradecanoylphorbol Acetate	135-138	tumor protein p53	Homo sapiens	91-94
29660338-9	2018	A strong binding of sp1, p53 and CREB proteins with HTLV-1 LTR and strong binding of NF-kappaB with HIV-1 LTR were observed after long (24 h) and short (6 h) exposures to TPA respectively by Chip assay.	Tetradecanoylphorbol Acetate	171-174	tumor protein p53	Homo sapiens	25-28
29660338-10	2018	These results support the possibility that sp1, p53 and CREB are involved in the TPA induced HTLV-1 LTR expression while TPA activation of HIV-1 LTR seems to be dependent on PKC activity through the NF-kappaB pathway.	Tetradecanoylphorbol Acetate	81-84	tumor protein p53	Homo sapiens	48-51
29292524-8	2018	When stimulated with PMA/ionomycin, CD4+ T cells from women with EP presented significantly higher interferon (IFN)-gamma and interleukin (IL)-17 secretion, and lower transforming growth factor (TGF)-beta secretion.	Tetradecanoylphorbol Acetate	21-24	CD4 molecule	Homo sapiens	36-39
29292524-8	2018	When stimulated with PMA/ionomycin, CD4+ T cells from women with EP presented significantly higher interferon (IFN)-gamma and interleukin (IL)-17 secretion, and lower transforming growth factor (TGF)-beta secretion.	Tetradecanoylphorbol Acetate	21-24	interferon gamma	Homo sapiens	99-121
29292524-8	2018	When stimulated with PMA/ionomycin, CD4+ T cells from women with EP presented significantly higher interferon (IFN)-gamma and interleukin (IL)-17 secretion, and lower transforming growth factor (TGF)-beta secretion.	Tetradecanoylphorbol Acetate	21-24	transforming growth factor beta 1	Homo sapiens	167-204
29422380-1	2018	BACKGROUND: In acute ischemic stroke (AIS), treatment with intravenous tissue-type plasminogen activator (IV-tPA) is time-sensitive.	Tetradecanoylphorbol Acetate	109-112	plasminogen activator, tissue type	Homo sapiens	71-104
29477140-3	2018	We observed that, upon phorbol 12-myristate 13-acetate (PMA) treatment, THP-1 cells differentiated into monocytes by down-regulating Aurora kinase A (AURKA), resulting in a reduction in H3S10 phosphorylation.	Tetradecanoylphorbol Acetate	56-59	GLI family zinc finger 2	Homo sapiens	72-77
29477140-6	2018	Furthermore, we found that treatment with the KDM6B inhibitor GSK-J4 perturbed the PMA-mediated differentiation of THP-1 cells.	Tetradecanoylphorbol Acetate	83-86	GLI family zinc finger 2	Homo sapiens	115-120
29723216-3	2018	Here, the tyrosine phosphorylation of SLC11A1 is observed in SLC11A1-expressing U937 cells when differentiated into macrophages by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	131-156	solute carrier family 11 member 1	Homo sapiens	38-45
29872754-0	2018	Induction of nerve growth factor by phorbol 12-myristate 13-acetate is dependent upon the mitogen activated protein kinase pathway.	Tetradecanoylphorbol Acetate	36-67	nerve growth factor	Homo sapiens	13-32
29872754-2	2018	To map the signal transduction cascade leading to NGF synthesis and secretion, cultured human glial cells were stimulated by phorbol 12-myristate 13-acetate (PMA), an agonist of Protein Kinase C. Changes in intracellular protein phosphorylation states were evaluated by reverse phase protein microarrays (RPPA), selectively screening over 130 protein endpoints.	Tetradecanoylphorbol Acetate	158-161	nerve growth factor	Homo sapiens	50-53
29474975-4	2018	The cAMP inducer forskolin (10 muM) and protein kinase C stimulant phorbol myristate acetate (1 muM) increased CYP19A1 mRNA levels by 1.8- and 1.6-fold, respectively, as well as inducing aromatase catalytic activity.	Tetradecanoylphorbol Acetate	67-92	latexin	Homo sapiens	96-99
29474975-4	2018	The cAMP inducer forskolin (10 muM) and protein kinase C stimulant phorbol myristate acetate (1 muM) increased CYP19A1 mRNA levels by 1.8- and 1.6-fold, respectively, as well as inducing aromatase catalytic activity.	Tetradecanoylphorbol Acetate	67-92	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	111-118
29723216-3	2018	Here, the tyrosine phosphorylation of SLC11A1 is observed in SLC11A1-expressing U937 cells when differentiated into macrophages by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	131-156	solute carrier family 11 member 1	Homo sapiens	61-68
29723216-3	2018	Here, the tyrosine phosphorylation of SLC11A1 is observed in SLC11A1-expressing U937 cells when differentiated into macrophages by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	158-161	solute carrier family 11 member 1	Homo sapiens	38-45
29723216-3	2018	Here, the tyrosine phosphorylation of SLC11A1 is observed in SLC11A1-expressing U937 cells when differentiated into macrophages by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	158-161	solute carrier family 11 member 1	Homo sapiens	61-68
29723216-6	2018	We found that PMA induces the interaction of SLC11A1 with c-Src kinase.	Tetradecanoylphorbol Acetate	14-17	solute carrier family 11 member 1	Homo sapiens	45-52
29531138-4	2018	In vitro analysis indicated that HMGB1, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-1beta (IL-1beta) were secreted in response to tumor necrosis factor-alpha (TNF-alpha) stimuli in human gingival epithelial cells (HGECs) and human monocytic leukemia cells (THP-1) treated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	308-333	interleukin 1 beta	Homo sapiens	103-120
29555853-4	2018	Wild-type p65 or p65DeltaSE both rescue NF-kappaB-dependent gene expression in p65-deficient murine hippocampal neurons responding to diffuse (PMA/ionomycin) stimulation.	Tetradecanoylphorbol Acetate	143-146	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	40-49
29531138-4	2018	In vitro analysis indicated that HMGB1, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-1beta (IL-1beta) were secreted in response to tumor necrosis factor-alpha (TNF-alpha) stimuli in human gingival epithelial cells (HGECs) and human monocytic leukemia cells (THP-1) treated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	308-333	interleukin 1 beta	Homo sapiens	122-130
29371085-5	2018	PMA induced the translocation of PKCs from the cytosol to the membrane and phosphorylated JNK.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	90-93
29531138-4	2018	In vitro analysis indicated that HMGB1, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-1beta (IL-1beta) were secreted in response to tumor necrosis factor-alpha (TNF-alpha) stimuli in human gingival epithelial cells (HGECs) and human monocytic leukemia cells (THP-1) treated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	308-333	tumor necrosis factor	Homo sapiens	161-188
29566330-4	2018	Sensors operated under optimized TPA parameters retained high sensitivity (57.4 +- 13.0 nA/muM), a wide linear dynamic range (150 nM-15 muM), fast response times (&lt;10 s), and a submicromolar detection limit (&lt;100 nM) upon consecutive calibration cycles.	Tetradecanoylphorbol Acetate	33-36	latexin	Homo sapiens	91-94
29566330-4	2018	Sensors operated under optimized TPA parameters retained high sensitivity (57.4 +- 13.0 nA/muM), a wide linear dynamic range (150 nM-15 muM), fast response times (&lt;10 s), and a submicromolar detection limit (&lt;100 nM) upon consecutive calibration cycles.	Tetradecanoylphorbol Acetate	33-36	latexin	Homo sapiens	136-139
29849923-7	2018	HT, in a concentration-dependent manner, improved endothelial mitochondrial function by reverting the PMA-induced reduction of mitochondrial membrane potential, ATP synthesis, and ATP5beta expression.	Tetradecanoylphorbol Acetate	102-105	ATP synthase F1 subunit beta	Homo sapiens	180-188
29371085-0	2018	(E)-2-Methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol attenuates PMA-induced inflammatory responses in human monocytic cells through PKCdelta/JNK/AP-1 pathways.	Tetradecanoylphorbol Acetate	71-74	PROP paired-like homeobox 1	Homo sapiens	37-43
29371085-0	2018	(E)-2-Methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol attenuates PMA-induced inflammatory responses in human monocytic cells through PKCdelta/JNK/AP-1 pathways.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase 8	Homo sapiens	148-151
29371085-0	2018	(E)-2-Methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol attenuates PMA-induced inflammatory responses in human monocytic cells through PKCdelta/JNK/AP-1 pathways.	Tetradecanoylphorbol Acetate	71-74	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	152-156
29371085-6	2018	MMPP inhibited PMA-induced membrane translocation of PKCdelta, phosphorylation of JNK, and nuclear translocation of AP-1, resulting in downregulation of cyclooxygenase-2 and chemokine ligand 5 production.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 8	Homo sapiens	82-85
29371085-6	2018	MMPP inhibited PMA-induced membrane translocation of PKCdelta, phosphorylation of JNK, and nuclear translocation of AP-1, resulting in downregulation of cyclooxygenase-2 and chemokine ligand 5 production.	Tetradecanoylphorbol Acetate	15-18	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-120
29371085-6	2018	MMPP inhibited PMA-induced membrane translocation of PKCdelta, phosphorylation of JNK, and nuclear translocation of AP-1, resulting in downregulation of cyclooxygenase-2 and chemokine ligand 5 production.	Tetradecanoylphorbol Acetate	15-18	prostaglandin-endoperoxide synthase 2	Homo sapiens	153-169
29371085-7	2018	These findings indicate that MMPP inhibits inflammatory responses in THP-1 cells by mitigating PMA-induced activation of PKCdelta and JNK and nuclear translocation of AP-1.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 8	Homo sapiens	134-137
29371085-7	2018	These findings indicate that MMPP inhibits inflammatory responses in THP-1 cells by mitigating PMA-induced activation of PKCdelta and JNK and nuclear translocation of AP-1.	Tetradecanoylphorbol Acetate	95-98	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-171
29633755-8	2018	We also found that the expression of TGF-beta1 and PDGF, as well as the proliferation and cell activity of HSCs, were significantly enhanced by the PKC agonist phorbol 12-myristate 13-acetate (PMA), but suppressed by the PKC antagonist calphostin C. CONCLUSIONS We found that IL-13, PGE2, and PGI2 stimulated HSCs proliferation and secretion of TGF-beta1 and PDGF by activating PKC, which predicted their potential roles in hepatic fibrosis.	Tetradecanoylphorbol Acetate	160-191	transforming growth factor beta 1	Homo sapiens	37-46
29633755-8	2018	We also found that the expression of TGF-beta1 and PDGF, as well as the proliferation and cell activity of HSCs, were significantly enhanced by the PKC agonist phorbol 12-myristate 13-acetate (PMA), but suppressed by the PKC antagonist calphostin C. CONCLUSIONS We found that IL-13, PGE2, and PGI2 stimulated HSCs proliferation and secretion of TGF-beta1 and PDGF by activating PKC, which predicted their potential roles in hepatic fibrosis.	Tetradecanoylphorbol Acetate	160-191	interleukin 13	Homo sapiens	276-281
29633755-8	2018	We also found that the expression of TGF-beta1 and PDGF, as well as the proliferation and cell activity of HSCs, were significantly enhanced by the PKC agonist phorbol 12-myristate 13-acetate (PMA), but suppressed by the PKC antagonist calphostin C. CONCLUSIONS We found that IL-13, PGE2, and PGI2 stimulated HSCs proliferation and secretion of TGF-beta1 and PDGF by activating PKC, which predicted their potential roles in hepatic fibrosis.	Tetradecanoylphorbol Acetate	160-191	transforming growth factor beta 1	Homo sapiens	345-354
29633755-8	2018	We also found that the expression of TGF-beta1 and PDGF, as well as the proliferation and cell activity of HSCs, were significantly enhanced by the PKC agonist phorbol 12-myristate 13-acetate (PMA), but suppressed by the PKC antagonist calphostin C. CONCLUSIONS We found that IL-13, PGE2, and PGI2 stimulated HSCs proliferation and secretion of TGF-beta1 and PDGF by activating PKC, which predicted their potential roles in hepatic fibrosis.	Tetradecanoylphorbol Acetate	193-196	transforming growth factor beta 1	Homo sapiens	37-46
29633755-8	2018	We also found that the expression of TGF-beta1 and PDGF, as well as the proliferation and cell activity of HSCs, were significantly enhanced by the PKC agonist phorbol 12-myristate 13-acetate (PMA), but suppressed by the PKC antagonist calphostin C. CONCLUSIONS We found that IL-13, PGE2, and PGI2 stimulated HSCs proliferation and secretion of TGF-beta1 and PDGF by activating PKC, which predicted their potential roles in hepatic fibrosis.	Tetradecanoylphorbol Acetate	193-196	interleukin 13	Homo sapiens	276-281
29633755-8	2018	We also found that the expression of TGF-beta1 and PDGF, as well as the proliferation and cell activity of HSCs, were significantly enhanced by the PKC agonist phorbol 12-myristate 13-acetate (PMA), but suppressed by the PKC antagonist calphostin C. CONCLUSIONS We found that IL-13, PGE2, and PGI2 stimulated HSCs proliferation and secretion of TGF-beta1 and PDGF by activating PKC, which predicted their potential roles in hepatic fibrosis.	Tetradecanoylphorbol Acetate	193-196	transforming growth factor beta 1	Homo sapiens	345-354
29683455-9	2018	By adimistration of 10 ng/mL phorbol 12-myristate 13-acetate (PMA) for 72 h, THP-1 cells differentiated into macrophages to form inflammatory foci in GTE (iGTE) (IGTE also can be stumilated with 2 microg/mL of lipopolysaccharides (LPS) for 48 h to initiate inflammation).	Tetradecanoylphorbol Acetate	29-60	GLI family zinc finger 2	Homo sapiens	77-82
29683455-9	2018	By adimistration of 10 ng/mL phorbol 12-myristate 13-acetate (PMA) for 72 h, THP-1 cells differentiated into macrophages to form inflammatory foci in GTE (iGTE) (IGTE also can be stumilated with 2 microg/mL of lipopolysaccharides (LPS) for 48 h to initiate inflammation).	Tetradecanoylphorbol Acetate	62-65	GLI family zinc finger 2	Homo sapiens	77-82
29538403-0	2018	The phorbol 12-myristate-13-acetate differentiation protocol is critical to the interaction of THP-1 macrophages with Salmonella Typhimurium.	Tetradecanoylphorbol Acetate	4-35	GLI family zinc finger 2	Homo sapiens	95-100
29313085-4	2018	We have analysed correlations between expression of LOC107987281 lncRNA and TGM2 mRNA by real-time PCR in K562 cell line untreated or treated with the anticancer drugs TPA (12-O-tetradecanoylphorbol-13-acetate), Docetaxel and Doxorubicin.	Tetradecanoylphorbol Acetate	168-171	LOC107987281	Homo sapiens	52-64
29313085-4	2018	We have analysed correlations between expression of LOC107987281 lncRNA and TGM2 mRNA by real-time PCR in K562 cell line untreated or treated with the anticancer drugs TPA (12-O-tetradecanoylphorbol-13-acetate), Docetaxel and Doxorubicin.	Tetradecanoylphorbol Acetate	168-171	transglutaminase 2	Homo sapiens	76-80
29313085-4	2018	We have analysed correlations between expression of LOC107987281 lncRNA and TGM2 mRNA by real-time PCR in K562 cell line untreated or treated with the anticancer drugs TPA (12-O-tetradecanoylphorbol-13-acetate), Docetaxel and Doxorubicin.	Tetradecanoylphorbol Acetate	173-209	LOC107987281	Homo sapiens	52-64
29313085-8	2018	The analysis of total RNA samples in GEO datasets from K562, HL-60, THP-1 and U937 cell lines, untreated or treated with TPA in replicated experiments confirmed our earlier results.	Tetradecanoylphorbol Acetate	121-124	GLI family zinc finger 2	Homo sapiens	68-73
29271701-6	2018	Furthermore, RGO induced the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant enzyme heme oxygenase-1 (HO-1) expression, and effectively blocked the overproduction of TPA-induced reactive oxygen species.	Tetradecanoylphorbol Acetate	190-193	NFE2 like bZIP transcription factor 2	Homo sapiens	74-78
29933732-0	2018	[Investigation of cytokine and midkine responses of human THP-1 leukemia cells induced by phorbol-12-Myristate-13-Acetate (PMA) at different concentrations and times].	Tetradecanoylphorbol Acetate	90-121	midkine	Homo sapiens	31-38
29933732-0	2018	[Investigation of cytokine and midkine responses of human THP-1 leukemia cells induced by phorbol-12-Myristate-13-Acetate (PMA) at different concentrations and times].	Tetradecanoylphorbol Acetate	90-121	GLI family zinc finger 2	Homo sapiens	58-63
29933732-0	2018	[Investigation of cytokine and midkine responses of human THP-1 leukemia cells induced by phorbol-12-Myristate-13-Acetate (PMA) at different concentrations and times].	Tetradecanoylphorbol Acetate	123-126	midkine	Homo sapiens	31-38
29933732-0	2018	[Investigation of cytokine and midkine responses of human THP-1 leukemia cells induced by phorbol-12-Myristate-13-Acetate (PMA) at different concentrations and times].	Tetradecanoylphorbol Acetate	123-126	GLI family zinc finger 2	Homo sapiens	58-63
29458014-4	2018	Subsequently l-theanine ameliorated TPA-induced erythema, vascular permeability increase, epidermal and dermal hyperplasia, neutrophil infiltration and activation via downregulating the expression of PECAM-1 (a platelet endothelial adhesion molecule-1) in blood vessels and the production of pro-inflammatory cytokines IL-1beta, TNF-alpha, and mediator cyclooxygenase-2 (COX-2), which is mainly expressed in neutrophils.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Mus musculus	319-327
29458014-4	2018	Subsequently l-theanine ameliorated TPA-induced erythema, vascular permeability increase, epidermal and dermal hyperplasia, neutrophil infiltration and activation via downregulating the expression of PECAM-1 (a platelet endothelial adhesion molecule-1) in blood vessels and the production of pro-inflammatory cytokines IL-1beta, TNF-alpha, and mediator cyclooxygenase-2 (COX-2), which is mainly expressed in neutrophils.	Tetradecanoylphorbol Acetate	36-39	tumor necrosis factor	Mus musculus	329-338
29538403-1	2018	THP-1 cells differentiated with phorbol 12-myristate 13-acetate (PMA) are widely used as a model for function and biology of human macrophages.	Tetradecanoylphorbol Acetate	65-68	GLI family zinc finger 2	Homo sapiens	0-5
29779272-6	2018	Eventually, the measure of phosphorylation of extracellular regulated protein kinases (ERK)1/2 was performed by Western blotting in PMA-treated Tca8113 cells.	Tetradecanoylphorbol Acetate	132-135	mitogen-activated protein kinase 3	Homo sapiens	46-94
29561757-7	2018	Activation of SNAT3-mediated glutamine transport in these astrocytes was reduced to 77 +- 6% when PKC was activated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	121-152	solute carrier family 38 member 3	Homo sapiens	14-19
29561757-7	2018	Activation of SNAT3-mediated glutamine transport in these astrocytes was reduced to 77 +- 6% when PKC was activated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	154-157	solute carrier family 38 member 3	Homo sapiens	14-19
29538403-1	2018	THP-1 cells differentiated with phorbol 12-myristate 13-acetate (PMA) are widely used as a model for function and biology of human macrophages.	Tetradecanoylphorbol Acetate	32-63	GLI family zinc finger 2	Homo sapiens	0-5
29407889-8	2018	Double-radiolabeled HDL (125I-TC-/[3H] CEt-HDL) was utilized to measure the effects of miR-24 on HDL and CE binding and SLU in HepG2 and PMA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	137-140	GLI family zinc finger 2	Homo sapiens	149-154
29072256-6	2018	Pretreatment with PKC inhibitor staurosporine significantly reduced ox-LDL-stimulated adhesion molecule expression and macrophage adhesion to endothelial cells, whereas pretreatment with PKC activator PMA/TPA attenuated the inhibitory effect of rapamycin on adhesion molecule expression.	Tetradecanoylphorbol Acetate	201-204	proline rich transmembrane protein 2	Homo sapiens	187-190
29072256-6	2018	Pretreatment with PKC inhibitor staurosporine significantly reduced ox-LDL-stimulated adhesion molecule expression and macrophage adhesion to endothelial cells, whereas pretreatment with PKC activator PMA/TPA attenuated the inhibitory effect of rapamycin on adhesion molecule expression.	Tetradecanoylphorbol Acetate	205-208	proline rich transmembrane protein 2	Homo sapiens	18-21
29072256-6	2018	Pretreatment with PKC inhibitor staurosporine significantly reduced ox-LDL-stimulated adhesion molecule expression and macrophage adhesion to endothelial cells, whereas pretreatment with PKC activator PMA/TPA attenuated the inhibitory effect of rapamycin on adhesion molecule expression.	Tetradecanoylphorbol Acetate	205-208	proline rich transmembrane protein 2	Homo sapiens	187-190
28600650-3	2018	The differentiation of THP-1 monocytes into macrophages was achieved by administration of phorbol myristate acetate.	Tetradecanoylphorbol Acetate	90-115	GLI family zinc finger 2	Homo sapiens	23-28
29710490-8	2018	Therefore, the result demonstrates that the anti-metastatic effects of a proton beam in TPA-treated HepG2 cells are associated with the inhibition of MMP-9 activity and the down-regulations of MMP-9, uPA, uPAR, Snail-1 and VEGF gene expression via the p38 MAPK/c-Fos signaling pathway.	Tetradecanoylphorbol Acetate	88-91	plasminogen activator, urokinase	Homo sapiens	200-203
29710490-0	2018	Anti-metastatic potential of a proton beam is regulated by p38 MAPK/c-Fos signaling pathway in TPA-treated HepG2 human hepatocellular carcinoma.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 14	Homo sapiens	59-62
29710490-8	2018	Therefore, the result demonstrates that the anti-metastatic effects of a proton beam in TPA-treated HepG2 cells are associated with the inhibition of MMP-9 activity and the down-regulations of MMP-9, uPA, uPAR, Snail-1 and VEGF gene expression via the p38 MAPK/c-Fos signaling pathway.	Tetradecanoylphorbol Acetate	88-91	snail family transcriptional repressor 1	Homo sapiens	211-218
29710490-6	2018	Furthermore, a proton beam suppressed TPA-induced gene expressions of urokinase plasminogen activator (uPA), uPA receptor (uPAR), Snail-1 and vascular endothelial growth factor (VEGF) in HepG2 cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	38-41	plasminogen activator, urokinase	Homo sapiens	70-101
29710490-6	2018	Furthermore, a proton beam suppressed TPA-induced gene expressions of urokinase plasminogen activator (uPA), uPA receptor (uPAR), Snail-1 and vascular endothelial growth factor (VEGF) in HepG2 cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	38-41	plasminogen activator, urokinase	Homo sapiens	103-106
29710490-8	2018	Therefore, the result demonstrates that the anti-metastatic effects of a proton beam in TPA-treated HepG2 cells are associated with the inhibition of MMP-9 activity and the down-regulations of MMP-9, uPA, uPAR, Snail-1 and VEGF gene expression via the p38 MAPK/c-Fos signaling pathway.	Tetradecanoylphorbol Acetate	88-91	vascular endothelial growth factor A	Homo sapiens	223-227
29710490-6	2018	Furthermore, a proton beam suppressed TPA-induced gene expressions of urokinase plasminogen activator (uPA), uPA receptor (uPAR), Snail-1 and vascular endothelial growth factor (VEGF) in HepG2 cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	38-41	snail family transcriptional repressor 1	Homo sapiens	130-137
29710490-8	2018	Therefore, the result demonstrates that the anti-metastatic effects of a proton beam in TPA-treated HepG2 cells are associated with the inhibition of MMP-9 activity and the down-regulations of MMP-9, uPA, uPAR, Snail-1 and VEGF gene expression via the p38 MAPK/c-Fos signaling pathway.	Tetradecanoylphorbol Acetate	88-91	mitogen-activated protein kinase 14	Homo sapiens	252-255
29710490-6	2018	Furthermore, a proton beam suppressed TPA-induced gene expressions of urokinase plasminogen activator (uPA), uPA receptor (uPAR), Snail-1 and vascular endothelial growth factor (VEGF) in HepG2 cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	38-41	vascular endothelial growth factor A	Homo sapiens	142-176
29710490-6	2018	Furthermore, a proton beam suppressed TPA-induced gene expressions of urokinase plasminogen activator (uPA), uPA receptor (uPAR), Snail-1 and vascular endothelial growth factor (VEGF) in HepG2 cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	38-41	vascular endothelial growth factor A	Homo sapiens	178-182
29628981-12	2018	The selective PPARgamma antagonist GW9662 reversed MMP-9 inhibition by troglitazone in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	87-90	peroxisome proliferator activated receptor gamma	Homo sapiens	14-23
29167066-5	2018	Native FAM19A4 secreted by phorblo 12-myristate 13-acetate (PMA) and LPS stimulated THP-1 cells could also be detected by this method.	Tetradecanoylphorbol Acetate	60-63	TAFA chemokine like family member 4	Homo sapiens	7-14
29286116-3	2018	When induced by phorbol myristate acetate (PMA) the monocytes differentiated into macrophages, and BAMBI also increased the migration of PMA-induced macrophages compared with control cells.	Tetradecanoylphorbol Acetate	16-41	BMP and activin membrane bound inhibitor	Homo sapiens	99-104
28722764-6	2018	In this paper we report that treatment with TPA reduces the expression of EZH2 without affecting levels of H3K27me3.	Tetradecanoylphorbol Acetate	44-47	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	74-78
28722764-7	2018	The combination of TPA with GSK126, an inhibitor of the catalytic activity of EZH2, has a synergic effect on the induction of muscle differentiation in RD rhabdomyosarcoma cells, suggesting a new therapeutic combinatory approach for RMS treatment.	Tetradecanoylphorbol Acetate	19-22	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	78-82
29452158-8	2018	However, direct activation of PKC by phorbol 12-myristate 13-acetate (PMA) increased the cloned human IKs in HEK293 cells.	Tetradecanoylphorbol Acetate	37-68	protein kinase C alpha	Homo sapiens	30-33
29452158-8	2018	However, direct activation of PKC by phorbol 12-myristate 13-acetate (PMA) increased the cloned human IKs in HEK293 cells.	Tetradecanoylphorbol Acetate	70-73	protein kinase C alpha	Homo sapiens	30-33
29286116-3	2018	When induced by phorbol myristate acetate (PMA) the monocytes differentiated into macrophages, and BAMBI also increased the migration of PMA-induced macrophages compared with control cells.	Tetradecanoylphorbol Acetate	43-46	BMP and activin membrane bound inhibitor	Homo sapiens	99-104
29520230-3	2018	In view of their distinct developmental origins and phenotypic attributes, we set out to assess the extent to which human monocyte-derived macrophages (MDMs) and phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells were overlapping across a variety of responses to activating stimuli.	Tetradecanoylphorbol Acetate	162-193	GLI family zinc finger 2	Homo sapiens	215-220
29520230-3	2018	In view of their distinct developmental origins and phenotypic attributes, we set out to assess the extent to which human monocyte-derived macrophages (MDMs) and phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells were overlapping across a variety of responses to activating stimuli.	Tetradecanoylphorbol Acetate	195-198	GLI family zinc finger 2	Homo sapiens	215-220
29467761-0	2018	Establishment of the Reference Intervals of Lymphocyte Function in Healthy Adults Based on IFN-gamma Secretion Assay upon Phorbol-12-Myristate-13-Acetate/Ionomycin Stimulation.	Tetradecanoylphorbol Acetate	122-153	interferon gamma	Homo sapiens	91-100
29603113-8	2018	In summary, our results show that FX activates the Nrf2 signaling pathway, induces the epigenetic demethylation of CpG sites in Nrf2 and blocks the TPA-induced transformation of JB6 P+ cells, indicating the potential health-promoting effects of FX in skin cancer prevention.	Tetradecanoylphorbol Acetate	148-151	NFE2 like bZIP transcription factor 2	Homo sapiens	51-55
29603113-8	2018	In summary, our results show that FX activates the Nrf2 signaling pathway, induces the epigenetic demethylation of CpG sites in Nrf2 and blocks the TPA-induced transformation of JB6 P+ cells, indicating the potential health-promoting effects of FX in skin cancer prevention.	Tetradecanoylphorbol Acetate	148-151	NFE2 like bZIP transcription factor 2	Homo sapiens	128-132
29497296-7	2018	In addition, phorbol-12-myristate-13-acetate was injected intraperitoneally immediately after the anti-TNF-alpha antibody microinjection.	Tetradecanoylphorbol Acetate	13-44	tumor necrosis factor	Rattus norvegicus	103-112
29445164-4	2018	TRPM7 kinase-dead (KD) K1646R knock-in mice exhibited splenomegaly and impaired blastogenic responses elicited by PMA/ionomycin or anti-CD3/CD28 antibodies.	Tetradecanoylphorbol Acetate	114-117	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	0-5
28771803-5	2018	Depletion of NF-kappaB by stable expression of a super-repressor form of IkappaBalpha in THP-1 cells caused remarkable cell death during phorbol 12-myristate 13-acetate (PMA)-induced differentiation.	Tetradecanoylphorbol Acetate	137-168	nuclear factor kappa B subunit 1	Homo sapiens	13-22
29168020-5	2018	Furthermore, Atox-1 bound to the SOD3 promoter region in TPA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	57-60	superoxide dismutase 3	Homo sapiens	33-37
29168020-6	2018	The overexpression of Atox-1 in THP-1 cells significantly enhanced TPA-elicited SOD3 expression, whereas its knockdown suppressed this induction.	Tetradecanoylphorbol Acetate	67-70	superoxide dismutase 3	Homo sapiens	80-84
29168020-7	2018	The present results demonstrate that Atox-1 functions as a key molecule in TPA-elicited SOD3 expression.	Tetradecanoylphorbol Acetate	75-78	superoxide dismutase 3	Homo sapiens	88-92
29275177-5	2018	Phytohaemagglutinin and phorbol 12-myristate 13-acetate induced interleukin (IL)-2 production and activation of NF-kappaB signaling pathways, which were both inhibited by DES.	Tetradecanoylphorbol Acetate	24-55	interleukin 2	Homo sapiens	64-82
28771803-5	2018	Depletion of NF-kappaB by stable expression of a super-repressor form of IkappaBalpha in THP-1 cells caused remarkable cell death during phorbol 12-myristate 13-acetate (PMA)-induced differentiation.	Tetradecanoylphorbol Acetate	170-173	nuclear factor kappa B subunit 1	Homo sapiens	13-22
29207123-7	2018	In conclusion, berberine reduced NLRP3 inflammasone expression by suppressing the activation of the TLR4/Myd88/NF-kappaB signaling pathway in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	142-145	NLR family pyrin domain containing 3	Homo sapiens	33-38
29207123-0	2018	NACHT, LRR and PYD domains-containing protein 3 inflammasome is activated and inhibited by berberine via toll-like receptor 4/myeloid differentiation primary response gene 88/nuclear factor-kappaB pathway, in phorbol 12-myristate 13-acetate-induced macrophages.	Tetradecanoylphorbol Acetate	209-240	NLR family pyrin domain containing 3	Homo sapiens	0-47
29207123-7	2018	In conclusion, berberine reduced NLRP3 inflammasone expression by suppressing the activation of the TLR4/Myd88/NF-kappaB signaling pathway in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	142-145	nuclear factor kappa B subunit 1	Homo sapiens	111-120
29207123-2	2018	The present study investigated the expression of NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages, and aimed to identify the effects of berberine on the inflammasome.	Tetradecanoylphorbol Acetate	71-102	NLR family pyrin domain containing 3	Homo sapiens	49-54
29207123-2	2018	The present study investigated the expression of NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages, and aimed to identify the effects of berberine on the inflammasome.	Tetradecanoylphorbol Acetate	104-107	NLR family pyrin domain containing 3	Homo sapiens	49-54
29368698-9	2018	I3A inhibited TPA-induced inflammation and epidermal hyperplasia in female ICR mice by downregulating NF-kappaB and iNOS.	Tetradecanoylphorbol Acetate	14-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	102-111
29207123-5	2018	The present study demonstrated that NLRP3 inflammasome and IL-1beta were activated in PMA-induced macrophages in a time-dependent manner, whereas berberine significantly inhibited their expression in a dose-dependent manner in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	86-89	NLR family pyrin domain containing 3	Homo sapiens	36-41
29207123-5	2018	The present study demonstrated that NLRP3 inflammasome and IL-1beta were activated in PMA-induced macrophages in a time-dependent manner, whereas berberine significantly inhibited their expression in a dose-dependent manner in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	86-89	interleukin 1 beta	Homo sapiens	59-67
29288518-4	2018	The S-tagged C5a/RP S19-induced agonistic functions in macrophage-like cells that were differentiated from human promyelocytic leukemia HL-60 cells by phorbol-12-myristate-13-acetate were suppressed by deltaLf and deltaANXA3 co-overexpression.	Tetradecanoylphorbol Acetate	151-182	complement C5a receptor 1	Homo sapiens	13-16
29385060-2	2018	Various forms of OPN were identified in human monocytic THP-1 cells stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	82-113	GLI family zinc finger 2	Homo sapiens	56-61
29385060-2	2018	Various forms of OPN were identified in human monocytic THP-1 cells stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	115-118	GLI family zinc finger 2	Homo sapiens	56-61
29368698-9	2018	I3A inhibited TPA-induced inflammation and epidermal hyperplasia in female ICR mice by downregulating NF-kappaB and iNOS.	Tetradecanoylphorbol Acetate	14-17	nitric oxide synthase 2, inducible	Mus musculus	116-120
29079502-0	2018	Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models.	Tetradecanoylphorbol Acetate	69-72	arachidonate 15-lipoxygenase	Mus musculus	11-29
29146594-5	2018	Here we demonstrate that activation of protein kinase C (PKC) by phorbol myristate acetate, Gq/11-coupled GPCR, or epidermal growth factor receptor stimulation promotes beta-arrestin2 recruitment to unliganded AT1 angiotensin receptor (AT1R).	Tetradecanoylphorbol Acetate	65-90	arrestin beta 2	Homo sapiens	169-183
29959857-0	2018	Sp1 mediates phorbol ester (PMA)-induced expression of membrane-bound guanylyl cyclase GC-A in human monocytic THP-1 cells.	Tetradecanoylphorbol Acetate	28-31	grancalcin	Homo sapiens	87-91
29959857-6	2018	In this report we show that phorbol ester (PMA) induces transcription of a gene encoding GC-A in human monocytic THP-1 cells.	Tetradecanoylphorbol Acetate	43-46	grancalcin	Homo sapiens	89-93
29959857-10	2018	Taken together, our findings suggest that the PMA-stimulated PKC and MEK/ERK signaling pathways induce Sp1-mediated transcription of the GC-A encoding gene in human monocytic THP-1 cells.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase kinase 7	Homo sapiens	69-72
29959857-10	2018	Taken together, our findings suggest that the PMA-stimulated PKC and MEK/ERK signaling pathways induce Sp1-mediated transcription of the GC-A encoding gene in human monocytic THP-1 cells.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 3	Homo sapiens	73-76
29959857-10	2018	Taken together, our findings suggest that the PMA-stimulated PKC and MEK/ERK signaling pathways induce Sp1-mediated transcription of the GC-A encoding gene in human monocytic THP-1 cells.	Tetradecanoylphorbol Acetate	46-49	grancalcin	Homo sapiens	137-141
29723855-9	2018	DOPE clearly suppressed phorbol 12-myristate 13-acetate-induced PKCalpha activation in the cell-free and in situ PKC assay.	Tetradecanoylphorbol Acetate	24-55	protein kinase C, alpha	Mus musculus	64-72
30198385-6	2018	Exposing primary CD4+ TCM cells to BRACO19, an agent targeting telomeres, resulted in a higher rate of apoptosis for infected cultures at day 3 post-infection, during HIV-1 latency and for PMA-stimulated cultures with low level of HIV-1 reactivation.	Tetradecanoylphorbol Acetate	189-192	CD4 molecule	Homo sapiens	17-20
29723855-9	2018	DOPE clearly suppressed phorbol 12-myristate 13-acetate-induced PKCalpha activation in the cell-free and in situ PKC assay.	Tetradecanoylphorbol Acetate	24-55	protein kinase C, alpha	Mus musculus	64-67
28922584-3	2018	The pro-inflammatory properties of mold particles were examined in human bronchial epithelial cells (BEAS-2B) and THP-1 monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1.	Tetradecanoylphorbol Acetate	167-170	GLI family zinc finger 2	Homo sapiens	187-192
30282868-5	2018	WGE suppressed histamine/PMA-induced H1R gene up-regulation in HeLa cells.	Tetradecanoylphorbol Acetate	25-28	histamine receptor H 1	Rattus norvegicus	37-40
29287084-2	2017	While attempting to generate megakaryoblastic cell lines exogenously expressing cytochrome c variants, we discovered that endogenous cytochrome c expression increased both upon induction of differentiation with the phorbol ester phorbol 12-myristate 13-acetate (PMA), and as cell density increased.	Tetradecanoylphorbol Acetate	229-260	cytochrome c, somatic	Homo sapiens	133-145
28968695-11	2018	After stimulation in vitro with phorbol 12-myristate 13-acetate and ionomycin, the frequencies of Th22 and IL-22+ CD4+ lymphocytes were similar between patients with and without GCA.	Tetradecanoylphorbol Acetate	32-63	CD4 molecule	Homo sapiens	114-117
29287084-2	2017	While attempting to generate megakaryoblastic cell lines exogenously expressing cytochrome c variants, we discovered that endogenous cytochrome c expression increased both upon induction of differentiation with the phorbol ester phorbol 12-myristate 13-acetate (PMA), and as cell density increased.	Tetradecanoylphorbol Acetate	262-265	cytochrome c, somatic	Homo sapiens	133-145
29259250-3	2017	Herein, we investigated how Snail upregulated transcription of ZEB1 and MMP9 induced by the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA) in hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	107-144	snail family transcriptional repressor 1	Homo sapiens	28-33
29038278-8	2018	Fidaxomicin and OP-1118 also inhibited toxin A-mediated NF-kappaB phosphorylation and TNF-alpha expression in macrophages, which was reversed by the NF-kappaB activator phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	169-194	nuclear factor kappa B subunit 1	Homo sapiens	56-65
29038278-8	2018	Fidaxomicin and OP-1118 also inhibited toxin A-mediated NF-kappaB phosphorylation and TNF-alpha expression in macrophages, which was reversed by the NF-kappaB activator phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	169-194	tumor necrosis factor	Homo sapiens	86-95
29038278-8	2018	Fidaxomicin and OP-1118 also inhibited toxin A-mediated NF-kappaB phosphorylation and TNF-alpha expression in macrophages, which was reversed by the NF-kappaB activator phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	169-194	nuclear factor kappa B subunit 1	Homo sapiens	149-158
29038278-8	2018	Fidaxomicin and OP-1118 also inhibited toxin A-mediated NF-kappaB phosphorylation and TNF-alpha expression in macrophages, which was reversed by the NF-kappaB activator phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	196-199	nuclear factor kappa B subunit 1	Homo sapiens	56-65
29038278-8	2018	Fidaxomicin and OP-1118 also inhibited toxin A-mediated NF-kappaB phosphorylation and TNF-alpha expression in macrophages, which was reversed by the NF-kappaB activator phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	196-199	nuclear factor kappa B subunit 1	Homo sapiens	149-158
29267213-6	2017	PA treatment inhibited the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on upregulation of ERK1/2 activation, MMP-2 expression, cellular migration, and invasion of HeLa cells.	Tetradecanoylphorbol Acetate	37-73	mitogen-activated protein kinase 3	Homo sapiens	99-105
29267213-6	2017	PA treatment inhibited the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on upregulation of ERK1/2 activation, MMP-2 expression, cellular migration, and invasion of HeLa cells.	Tetradecanoylphorbol Acetate	75-78	mitogen-activated protein kinase 3	Homo sapiens	99-105
29259250-3	2017	Herein, we investigated how Snail upregulated transcription of ZEB1 and MMP9 induced by the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA) in hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	146-149	snail family transcriptional repressor 1	Homo sapiens	28-33
29259250-4	2017	According to deletion mapping and site directed mutagenesis analysis, the TPA-responsive elements on both MMP9 and ZEB1 promoters locate on a putative EGR1 and SP1 overlapping region coupled with an upstream proposed Snail binding motif TCACA.	Tetradecanoylphorbol Acetate	74-77	snail family transcriptional repressor 1	Homo sapiens	217-222
29259250-5	2017	Consistently, chromatin immunoprecipitation (ChIP) assay showed TPA triggered binding of Snail, EGR1 and SP1 on MMP9 and ZEB1 promoters.	Tetradecanoylphorbol Acetate	64-67	snail family transcriptional repressor 1	Homo sapiens	89-94
29259250-6	2017	Double ChIP further indicated TPA induced association of Snail with EGR1 and SP1 on both promoters.	Tetradecanoylphorbol Acetate	30-33	snail family transcriptional repressor 1	Homo sapiens	57-62
29259250-7	2017	Also, electrophoresis mobility shift assay revealed TPA enhanced binding of Snail with a MMP9 promoter fragment.	Tetradecanoylphorbol Acetate	52-55	snail family transcriptional repressor 1	Homo sapiens	76-81
29236713-8	2017	More mitochondrial reactive oxygen species (ROS) were generated in neutrophils and platelets of Sirt3-/- mice compared to WT, when stimulated with a low concentration of phorbol 12-myristate 13-acetate (PMA) and a high concentration of thrombin, respectively.	Tetradecanoylphorbol Acetate	203-206	coagulation factor II	Mus musculus	236-244
29130110-0	2017	Epimedium koreanum Nakai inhibits PMA-induced cancer cell migration and invasion by modulating NF-kappaB/MMP-9 signaling in monomorphic malignant human glioma cells.	Tetradecanoylphorbol Acetate	34-37	nuclear factor kappa B subunit 1	Homo sapiens	95-104
29225515-11	2017	NF-kappaB activator Phorbol 12-myristate13-acetate (PMA) can attenuate the antitumor activity of APS in both cell lines, but NF-kappaB inhibitor BAY 11-7082 (Bay) can enhance the effect of APS in both cell lines.	Tetradecanoylphorbol Acetate	20-50	nuclear factor kappa B subunit 1	Homo sapiens	0-9
29225515-11	2017	NF-kappaB activator Phorbol 12-myristate13-acetate (PMA) can attenuate the antitumor activity of APS in both cell lines, but NF-kappaB inhibitor BAY 11-7082 (Bay) can enhance the effect of APS in both cell lines.	Tetradecanoylphorbol Acetate	52-55	nuclear factor kappa B subunit 1	Homo sapiens	0-9
29276179-8	2017	To evaluate cell proliferation and cytokine production, CD4+ T cells were isolated and stimulated with phytohemagglutinin and PMA/ionomycin.	Tetradecanoylphorbol Acetate	126-129	CD4 molecule	Homo sapiens	56-59
28513986-7	2017	TPA markedly downregulated the expression of PKCalpha, PKCdelta, and PKCepsilon, suggesting that PKCdelta or PKCepsilon activation could contribute to inhibition of glucose transport by FFA.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	45-53
28983613-6	2017	Suspended THP-1 cells were stimulated for 2 days with 5 or 100 ng/ml phorbol-12 myristate-13 acetate (PMA) in order to induce the cells to differentiate into adherent macrophages.	Tetradecanoylphorbol Acetate	69-100	GLI family zinc finger 2	Homo sapiens	10-15
28983613-6	2017	Suspended THP-1 cells were stimulated for 2 days with 5 or 100 ng/ml phorbol-12 myristate-13 acetate (PMA) in order to induce the cells to differentiate into adherent macrophages.	Tetradecanoylphorbol Acetate	102-105	GLI family zinc finger 2	Homo sapiens	10-15
29130110-8	2017	Taken together, our results suggest that EYK suppresses PMA-induced cancer cell migration in monomorphic malignant human glioma cells by downregulating the NF-kappaB pathway and decreasing MMP-9 activity.	Tetradecanoylphorbol Acetate	56-59	nuclear factor kappa B subunit 1	Homo sapiens	156-165
29212118-5	2017	Treatment of whole blood with LPS or phorbol-myristate-acetate dramatically increased MPO plasma levels, and co-incubation with 4-ABAH, a specific MPO inhibitor, significantly enhanced the PCA in plasma supernatants.	Tetradecanoylphorbol Acetate	37-62	myeloperoxidase	Homo sapiens	86-89
29162709-5	2017	On the basis of a luminol-dependent chemiluminescence assay, E. chaffeensis inhibited phorbol myristate acetate (PMA)-induced ROS generation by BMDMs from wild-type, but not DNase X-/-, mice.	Tetradecanoylphorbol Acetate	113-116	deoxyribonuclease 1-like 1	Mus musculus	174-181
29170390-4	2017	Stimulation with CD3/CD28, PMA/ionomycin, or latency reversing agents prostratin and SAHA, yielded increased phosphorylation of IkappaBalpha, ERK, p38, and JNK in HIV-infected cells across two in vitro latency models.	Tetradecanoylphorbol Acetate	27-30	NFKB inhibitor alpha	Homo sapiens	128-140
29170390-4	2017	Stimulation with CD3/CD28, PMA/ionomycin, or latency reversing agents prostratin and SAHA, yielded increased phosphorylation of IkappaBalpha, ERK, p38, and JNK in HIV-infected cells across two in vitro latency models.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Homo sapiens	142-145
29170390-4	2017	Stimulation with CD3/CD28, PMA/ionomycin, or latency reversing agents prostratin and SAHA, yielded increased phosphorylation of IkappaBalpha, ERK, p38, and JNK in HIV-infected cells across two in vitro latency models.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 14	Homo sapiens	147-150
29170390-4	2017	Stimulation with CD3/CD28, PMA/ionomycin, or latency reversing agents prostratin and SAHA, yielded increased phosphorylation of IkappaBalpha, ERK, p38, and JNK in HIV-infected cells across two in vitro latency models.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 8	Homo sapiens	156-159
29198314-10	2017	Following 72 h culture of T cells in SMG (SMG-T) or control static (Static-T) conditions, IL-2 production by the T cells was reduced in SMG-T cells compared to Static-T cells upon stimulation by phorbol 12-myristate 13-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	195-226	interleukin 2	Homo sapiens	90-94
29123208-5	2017	After activation with PMA/ionomycin, p-p38MAPK and p-AKT were significantly inhibited in CD4+ and CD8+ T cells when TAC was given, compared to pre-transplantation.	Tetradecanoylphorbol Acetate	22-25	AKT serine/threonine kinase 1	Homo sapiens	53-56
26390181-8	2017	Furthermore, Mw strongly suppressed PMA-induced membrane localization of protein kinase C alpha (PKCalpha) since PKCalpha inhibition caused a marked decrease in PMA-induced MMP-9 secretion as well as AKT/ERK-1/2 activation.	Tetradecanoylphorbol Acetate	36-39	protein kinase C, alpha	Mus musculus	73-95
26390181-8	2017	Furthermore, Mw strongly suppressed PMA-induced membrane localization of protein kinase C alpha (PKCalpha) since PKCalpha inhibition caused a marked decrease in PMA-induced MMP-9 secretion as well as AKT/ERK-1/2 activation.	Tetradecanoylphorbol Acetate	36-39	protein kinase C, alpha	Mus musculus	97-105
26390181-8	2017	Furthermore, Mw strongly suppressed PMA-induced membrane localization of protein kinase C alpha (PKCalpha) since PKCalpha inhibition caused a marked decrease in PMA-induced MMP-9 secretion as well as AKT/ERK-1/2 activation.	Tetradecanoylphorbol Acetate	36-39	protein kinase C, alpha	Mus musculus	113-121
26390181-8	2017	Furthermore, Mw strongly suppressed PMA-induced membrane localization of protein kinase C alpha (PKCalpha) since PKCalpha inhibition caused a marked decrease in PMA-induced MMP-9 secretion as well as AKT/ERK-1/2 activation.	Tetradecanoylphorbol Acetate	36-39	thymoma viral proto-oncogene 1	Mus musculus	200-203
26390181-8	2017	Furthermore, Mw strongly suppressed PMA-induced membrane localization of protein kinase C alpha (PKCalpha) since PKCalpha inhibition caused a marked decrease in PMA-induced MMP-9 secretion as well as AKT/ERK-1/2 activation.	Tetradecanoylphorbol Acetate	161-164	protein kinase C, alpha	Mus musculus	73-95
26390181-8	2017	Furthermore, Mw strongly suppressed PMA-induced membrane localization of protein kinase C alpha (PKCalpha) since PKCalpha inhibition caused a marked decrease in PMA-induced MMP-9 secretion as well as AKT/ERK-1/2 activation.	Tetradecanoylphorbol Acetate	161-164	protein kinase C, alpha	Mus musculus	97-105
26390181-8	2017	Furthermore, Mw strongly suppressed PMA-induced membrane localization of protein kinase C alpha (PKCalpha) since PKCalpha inhibition caused a marked decrease in PMA-induced MMP-9 secretion as well as AKT/ERK-1/2 activation.	Tetradecanoylphorbol Acetate	161-164	protein kinase C, alpha	Mus musculus	113-121
29198314-13	2017	When activation of SMG-T cells occurred in SMG, the T cells produced less IL-2 than control T cell cultures upon incubation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	129-132	interleukin 2	Homo sapiens	74-78
29198314-10	2017	Following 72 h culture of T cells in SMG (SMG-T) or control static (Static-T) conditions, IL-2 production by the T cells was reduced in SMG-T cells compared to Static-T cells upon stimulation by phorbol 12-myristate 13-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	228-231	interleukin 2	Homo sapiens	90-94
29039753-0	2017	PMA-Induced THP-1 Macrophage Differentiation is Not Impaired by Citrate-Coated Platinum Nanoparticles.	Tetradecanoylphorbol Acetate	0-3	GLI family zinc finger 2	Homo sapiens	12-17
28966330-3	2017	Activation of PKCalpha and PKCbeta by TPA (12-O-Tetradecanoylphorbol 13-acetate) increased MR proteins and its transcriptional activities in HEK293-MR cells.	Tetradecanoylphorbol Acetate	38-41	protein kinase C, alpha	Mus musculus	14-22
28966330-3	2017	Activation of PKCalpha and PKCbeta by TPA (12-O-Tetradecanoylphorbol 13-acetate) increased MR proteins and its transcriptional activities in HEK293-MR cells.	Tetradecanoylphorbol Acetate	43-79	protein kinase C, alpha	Mus musculus	14-22
29187870-11	2017	Moreover, the presence of Snail or Twist1 partially blocked phorbol 12-myristate 13-acetate-induced megakaryocyte differentiation, while that of Twist significantly altered imatinib-induced erythroid differentiation.	Tetradecanoylphorbol Acetate	60-91	snail family transcriptional repressor 1	Homo sapiens	26-31
29187870-11	2017	Moreover, the presence of Snail or Twist1 partially blocked phorbol 12-myristate 13-acetate-induced megakaryocyte differentiation, while that of Twist significantly altered imatinib-induced erythroid differentiation.	Tetradecanoylphorbol Acetate	60-91	twist family bHLH transcription factor 1	Homo sapiens	35-41
28765923-0	2017	Bombyx mori hemocyte extract has anti-inflammatory effects on human phorbol myristate acetate-differentiated THP-1 cells via TLR4-mediated suppression of the NF-kappaB signaling pathway.	Tetradecanoylphorbol Acetate	68-93	GLI family zinc finger 2	Homo sapiens	109-114
28830685-5	2017	PMA-treated THP-1 cells were co-cultured with human A549 cells culture supernatant.	Tetradecanoylphorbol Acetate	0-3	GLI family zinc finger 2	Homo sapiens	12-17
28986583-3	2017	Here we report the pro-inflammatory effect of ImI, a well characterized conotoxin that inhibits alpha7 nAChRs, on differentiated THP-1 pre-monocyte macrophages (MDM) obtained by phorbol 12-myristate 13 acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	178-209	GLI family zinc finger 2	Homo sapiens	129-134
28986583-3	2017	Here we report the pro-inflammatory effect of ImI, a well characterized conotoxin that inhibits alpha7 nAChRs, on differentiated THP-1 pre-monocyte macrophages (MDM) obtained by phorbol 12-myristate 13 acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	211-214	GLI family zinc finger 2	Homo sapiens	129-134
28608598-6	2017	It also induced expression of COX-2 and TNF-alpha mRNA in a dose-dependent manner in phorbol 12-myristate 13-acetate differentiated THP-1 cells, which play a crucial role during inflammation.	Tetradecanoylphorbol Acetate	85-116	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	30-35
28608598-6	2017	It also induced expression of COX-2 and TNF-alpha mRNA in a dose-dependent manner in phorbol 12-myristate 13-acetate differentiated THP-1 cells, which play a crucial role during inflammation.	Tetradecanoylphorbol Acetate	85-116	tumor necrosis factor	Homo sapiens	40-49
28926616-4	2017	Here, we report that mTORC1 activation by phorbol 12,13-myristate acetate (PMA) requires both classic, cPKC, and novel PKC (nPKC) isoforms, specifically PKCeta, acting through distinct pathways.	Tetradecanoylphorbol Acetate	75-78	protein kinase C alpha	Homo sapiens	104-107
28765903-5	2017	To examine the mechanism underlying the relationship between p53 and FN expression, we treated MCF7 breast cancer cells with the tumor promoter TPA (12-O-tetradecanoylphorbol-13-acetate).	Tetradecanoylphorbol Acetate	144-147	tumor protein p53	Homo sapiens	61-64
28765903-6	2017	Our results showed that basal FN expression was increased by TPA treatment in a time-dependent manner.	Tetradecanoylphorbol Acetate	61-64	fibronectin 1	Homo sapiens	30-32
28765903-7	2017	In contrast, the level of p53 expression was decreased by TPA treatment.	Tetradecanoylphorbol Acetate	58-61	tumor protein p53	Homo sapiens	26-29
28765903-9	2017	Furthermore, the alterations in FN and p53 expression in response to TPA were prevented by a specific MEK inhibitor, UO126.	Tetradecanoylphorbol Acetate	69-72	fibronectin 1	Homo sapiens	32-34
28765903-9	2017	Furthermore, the alterations in FN and p53 expression in response to TPA were prevented by a specific MEK inhibitor, UO126.	Tetradecanoylphorbol Acetate	69-72	tumor protein p53	Homo sapiens	39-42
28765903-10	2017	Finally, we demonstrated that TPA triggers degradation of p53 through the proteasomal pathway in MCF7 cells.	Tetradecanoylphorbol Acetate	30-33	tumor protein p53	Homo sapiens	58-61
28765903-11	2017	TPA-induced FN expression was decreased by the proteasome inhibitor MG132.	Tetradecanoylphorbol Acetate	0-3	fibronectin 1	Homo sapiens	12-14
30023750-6	2017	Furthermore, the strong two-photon absorption (TPA) with a maximum located at 820 nm along with a TPA cross section sigma2 &gt; 800 GM, and the marked changes in the position and intensity of the band upon complexation definitely make Ant-PIm a promising probe for two-photon excited fluorescence-based discrimination of HSA from BSA.	Tetradecanoylphorbol Acetate	47-50	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	239-242
30023750-6	2017	Furthermore, the strong two-photon absorption (TPA) with a maximum located at 820 nm along with a TPA cross section sigma2 &gt; 800 GM, and the marked changes in the position and intensity of the band upon complexation definitely make Ant-PIm a promising probe for two-photon excited fluorescence-based discrimination of HSA from BSA.	Tetradecanoylphorbol Acetate	47-50	albumin	Homo sapiens	321-324
28927117-0	2017	Salvia miltiorrhiza extract inhibits TPA-induced MMP-9 expression and invasion through the MAPK/AP-1 signaling pathway in human breast cancer MCF-7 cells.	Tetradecanoylphorbol Acetate	37-40	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	96-100
28970848-10	2017	CONCLUSION: The results indicated that the inhibitory effects of CFE against TPA-induced MMP-9 expression and MCF-7 cell invasion were dependent on the protein kinase C delta/p38/c-Jun N-terminal kinase/AP-1 pathway.	Tetradecanoylphorbol Acetate	77-80	mitogen-activated protein kinase 14	Homo sapiens	175-178
28927117-10	2017	SME suppressed TPA-induced MMP-9 expression and MCF-7 cell invasion by blocking the transcriptional activation of AP-1.	Tetradecanoylphorbol Acetate	15-18	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	114-118
28878626-8	2017	Finally, the expression of a dominant negative version of H-Ras, an upstream activator of ERK1/2, abolishes phorbol 12-myristate 13-acetate (PMA)-mediated down regulation of NET in a manner similar to MKP3.	Tetradecanoylphorbol Acetate	141-144	dual specificity phosphatase 6	Rattus norvegicus	201-205
27717886-4	2017	We observed that PKC activation with tetradecanoylphorbol acetate (TPA) increases the migration and invasion capacity of two human glioblastoma derived human cell lines (U251 MG and U87) and that the treatment with the PR receptor antagonist RU486 blocks these processes.	Tetradecanoylphorbol Acetate	37-65	protein kinase C alpha	Homo sapiens	17-20
27717886-4	2017	We observed that PKC activation with tetradecanoylphorbol acetate (TPA) increases the migration and invasion capacity of two human glioblastoma derived human cell lines (U251 MG and U87) and that the treatment with the PR receptor antagonist RU486 blocks these processes.	Tetradecanoylphorbol Acetate	67-70	protein kinase C alpha	Homo sapiens	17-20
28837583-6	2017	Analysis of hundreds of individual human peripheral blood NK cells profiled ex vivo revealed that CD56dimCD16+ NK cells are immediate secretors of interferon gamma (IFN-gamma) upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (&lt; 3 h), and that there was no evidence of cooperation between NK cells leading to either synergistic activation or faster IFN-gamma secretion.	Tetradecanoylphorbol Acetate	195-226	interferon gamma	Homo sapiens	147-174
28837583-6	2017	Analysis of hundreds of individual human peripheral blood NK cells profiled ex vivo revealed that CD56dimCD16+ NK cells are immediate secretors of interferon gamma (IFN-gamma) upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (&lt; 3 h), and that there was no evidence of cooperation between NK cells leading to either synergistic activation or faster IFN-gamma secretion.	Tetradecanoylphorbol Acetate	195-226	interferon gamma	Homo sapiens	165-174
28837583-6	2017	Analysis of hundreds of individual human peripheral blood NK cells profiled ex vivo revealed that CD56dimCD16+ NK cells are immediate secretors of interferon gamma (IFN-gamma) upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (&lt; 3 h), and that there was no evidence of cooperation between NK cells leading to either synergistic activation or faster IFN-gamma secretion.	Tetradecanoylphorbol Acetate	228-231	interferon gamma	Homo sapiens	147-174
28837583-6	2017	Analysis of hundreds of individual human peripheral blood NK cells profiled ex vivo revealed that CD56dimCD16+ NK cells are immediate secretors of interferon gamma (IFN-gamma) upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (&lt; 3 h), and that there was no evidence of cooperation between NK cells leading to either synergistic activation or faster IFN-gamma secretion.	Tetradecanoylphorbol Acetate	228-231	interferon gamma	Homo sapiens	165-174
28728065-8	2017	In cross-sectional analyses, multivariable-adjusted CRP was associated with plaque prevalence and total plaque area (TPA) in men and women.	Tetradecanoylphorbol Acetate	117-120	C-reactive protein	Homo sapiens	52-55
28715618-8	2017	SYTOX Green-positive cells were detected in human peripheral polymorphonuclear cells exposed to a NET inducer, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	111-142	ETS transcription factor ELK3	Homo sapiens	98-101
28715618-8	2017	SYTOX Green-positive cells were detected in human peripheral polymorphonuclear cells exposed to a NET inducer, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	144-147	ETS transcription factor ELK3	Homo sapiens	98-101
28728065-9	2017	Age-adjusted baseline CRP &gt;3 mg/L compared to CRP &lt;1 mg/L predicted novel plaque formation (OR 1.44, CI 1.08-1.92) and TPA progression (beta = 0.0.029 (CI, 0.003-0.056)) in men, but not in women.	Tetradecanoylphorbol Acetate	125-128	C-reactive protein	Homo sapiens	22-25
28728065-10	2017	In neither men nor women was baseline CRP a predictor of TPA-progression or novel plaque formation when adjusted for traditional risk factors.	Tetradecanoylphorbol Acetate	57-60	C-reactive protein	Homo sapiens	38-41
28728065-11	2017	CONCLUSIONS: CRP was associated with plaque presence and TPA in cross-sectional analyses, but was not an independent predictor of novel plaque formation or plaque progression.	Tetradecanoylphorbol Acetate	57-60	C-reactive protein	Homo sapiens	13-16
28789420-13	2017	Furthermore, KLF5 is essential for activity of the autocrine factor TNFalpha, which is secreted by cells treated with PMA and mediates the function of PMA-induced apoptosis through regulating the activity of JNK signaling pathway.	Tetradecanoylphorbol Acetate	118-121	tumor necrosis factor	Homo sapiens	68-76
28659229-2	2017	showed that homeopathic preparations of Arnica montana L. acted directly on gene expression of Tamm-Horsfall protein-1 (THP-1) monocyte/macrophage cell lines activated with phorbol12-myristate13-acetate and interleukin-4 (IL-4).	Tetradecanoylphorbol Acetate	173-202	GLI family zinc finger 2	Homo sapiens	120-125
28594273-11	2017	However, 53BP1 may be involved in this TPA activity because its overexpression significantly reduced the TPA stimulatory effect on BRCA1 and ERE expression.	Tetradecanoylphorbol Acetate	39-42	BP1	Homo sapiens	11-14
28594273-11	2017	However, 53BP1 may be involved in this TPA activity because its overexpression significantly reduced the TPA stimulatory effect on BRCA1 and ERE expression.	Tetradecanoylphorbol Acetate	105-108	BP1	Homo sapiens	11-14
28791192-1	2017	BACKGROUND: The DRAGON score, which includes clinical and computed tomographic (CT) scan parameters, predicts functional outcomes in ischemic stroke patients treated with intravenous tissue plasminogen activator (IV tPA).	Tetradecanoylphorbol Acetate	216-219	repulsive guidance molecule BMP co-receptor b	Homo sapiens	16-22
28791192-12	2017	CONCLUSIONS: The DRAGON score can help predict better functional outcomes in ischemic stroke patients receiving both IV tPA and endovascular therapy.	Tetradecanoylphorbol Acetate	120-123	repulsive guidance molecule BMP co-receptor b	Homo sapiens	17-23
28512205-0	2017	Phorbol-12-myristate-13-acetate-mediated stabilization of leukemia inhibitory factor (lif) mRNA: involvement of Nucleolin and PCBP1.	Tetradecanoylphorbol Acetate	0-31	poly(rC) binding protein 1	Homo sapiens	126-131
28512205-5	2017	Affinity chromatography followed by western blot and RNA co-immunoprecipitation of PMA-treated U937 extract identified Nucleolin and PCBP1 as two protein trans-factors interacting with lif mRNA, specifically to the proximal non-conventional AU-rich region.	Tetradecanoylphorbol Acetate	83-86	poly(rC) binding protein 1	Homo sapiens	133-138
28512205-6	2017	PMA induced nucleo-cytoplasmic translocation of both Nucleolin and PCBP1.	Tetradecanoylphorbol Acetate	0-3	poly(rC) binding protein 1	Homo sapiens	67-72
28575166-5	2017	Knocking out LTA4H significantly reduced skin cancer development in the 7,12-dimethylbenz(a)anthracene (DMBA)-initiated/12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted two-stage skin cancer mouse model.	Tetradecanoylphorbol Acetate	120-156	leukotriene A4 hydrolase	Mus musculus	13-18
28575166-5	2017	Knocking out LTA4H significantly reduced skin cancer development in the 7,12-dimethylbenz(a)anthracene (DMBA)-initiated/12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted two-stage skin cancer mouse model.	Tetradecanoylphorbol Acetate	158-161	leukotriene A4 hydrolase	Mus musculus	13-18
28402957-5	2017	Furthermore, we notice that a series of genes, including PI3KCA, NFATC1and TNFSF9, which play important roles during NK cell activation, were at "poised" state prior to activation, and that modifications of H3K4me3 and H3K27me3 on these promotors were sensitive to stimulation with Phorbol Myristate Acetate (PMA) and Ionomycin (Iono) in the NK92MI cell line.	Tetradecanoylphorbol Acetate	282-307	TNF superfamily member 9	Homo sapiens	75-81
28396116-3	2017	Beta2-adrenergic receptor (beta2AR) agonists were identified as the most potent inhibitors of phorbol myristate acetate-induced tumor necrosis factor-alpha production in rat bone marrow macrophages.	Tetradecanoylphorbol Acetate	94-119	tumor necrosis factor	Rattus norvegicus	128-155
29050234-9	2017	Via its interaction with IkappaBalpha, AURKC indirectly induced NF-kappaB activation; accordingly, AKCI decreased PMA-induced activation of NF-kappaB.	Tetradecanoylphorbol Acetate	114-117	NFKB inhibitor alpha	Homo sapiens	25-37
28402957-5	2017	Furthermore, we notice that a series of genes, including PI3KCA, NFATC1and TNFSF9, which play important roles during NK cell activation, were at "poised" state prior to activation, and that modifications of H3K4me3 and H3K27me3 on these promotors were sensitive to stimulation with Phorbol Myristate Acetate (PMA) and Ionomycin (Iono) in the NK92MI cell line.	Tetradecanoylphorbol Acetate	309-312	TNF superfamily member 9	Homo sapiens	75-81
28840015-9	2017	An example of a practice changing study in this aspect is the Multi-center Intrapleural Streptokinase Trial (MIST) 2 trial which demonstrated that a combination of intra-pleural tPA and DNAse improved outcomes in pleural infections compared to DNase or t-PA alone.	Tetradecanoylphorbol Acetate	178-181	plasminogen activator, tissue type	Homo sapiens	253-257
28381553-6	2017	Furthermore, knockdown of GIMAP6 not only rendered Jurkat cells sensitive to apoptosis but also accelerated T cell activation under phorbol 12-myristate 13-acetate/ionomycin treatment conditions.	Tetradecanoylphorbol Acetate	132-163	GTPase, IMAP family member 6	Homo sapiens	26-32
28634425-3	2017	Here, we triggered inflammation in HT1080 fibrosarcoma cells with phorbol-12-myristate-13-acetate (PMA), an inducer of COX-2 and of MT1-MMP.	Tetradecanoylphorbol Acetate	66-97	prostaglandin-endoperoxide synthase 2	Homo sapiens	119-124
28634425-3	2017	Here, we triggered inflammation in HT1080 fibrosarcoma cells with phorbol-12-myristate-13-acetate (PMA), an inducer of COX-2 and of MT1-MMP.	Tetradecanoylphorbol Acetate	99-102	prostaglandin-endoperoxide synthase 2	Homo sapiens	119-124
28634425-6	2017	Among the signal-transducing pathways explored, the silencing of MT1-MMP prevented PMA from phosphorylating extracellular signal-regulated kinase, inhibitor of kappaB, and p105 nuclear factor kappaB (NF-kappaB) intermediates.	Tetradecanoylphorbol Acetate	83-86	nuclear factor kappa B subunit 1	Homo sapiens	160-166
28634425-6	2017	Among the signal-transducing pathways explored, the silencing of MT1-MMP prevented PMA from phosphorylating extracellular signal-regulated kinase, inhibitor of kappaB, and p105 nuclear factor kappaB (NF-kappaB) intermediates.	Tetradecanoylphorbol Acetate	83-86	nuclear factor kappa B subunit 1	Homo sapiens	172-176
28634425-6	2017	Among the signal-transducing pathways explored, the silencing of MT1-MMP prevented PMA from phosphorylating extracellular signal-regulated kinase, inhibitor of kappaB, and p105 nuclear factor kappaB (NF-kappaB) intermediates.	Tetradecanoylphorbol Acetate	83-86	nuclear factor kappa B subunit 1	Homo sapiens	192-198
28634425-6	2017	Among the signal-transducing pathways explored, the silencing of MT1-MMP prevented PMA from phosphorylating extracellular signal-regulated kinase, inhibitor of kappaB, and p105 nuclear factor kappaB (NF-kappaB) intermediates.	Tetradecanoylphorbol Acetate	83-86	nuclear factor kappa B subunit 1	Homo sapiens	200-209
28645309-13	2017	CD4+ and CD8+ T cell populations isolated from the OB during latency were capable of responding to PMA/ionomycin in the production of IFN-gamma similar to T cells from other tissue that possess latent virus including the TG and brain stem.	Tetradecanoylphorbol Acetate	99-102	interferon gamma	Homo sapiens	134-143
28381553-8	2017	The conclusion from the study on cultured T cells was corroborated by the analysis of primary CD3+ T cells, showing that specific knockdown of GIMAP6 led to enhancement of phorbol 12-myristate 13-acetate/ionomycin-mediated activation signals.	Tetradecanoylphorbol Acetate	172-203	GTPase, IMAP family member 6	Homo sapiens	143-149
28276734-5	2017	In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	149-174	tumor necrosis factor	Homo sapiens	79-112
28431214-6	2017	The stimulation of tissue with phorbol-12-myristate-13-acetate and ionomycin, recapitulating CAVD microenvironment, resulted in IFN-gamma release.	Tetradecanoylphorbol Acetate	31-62	interferon gamma	Homo sapiens	128-137
28185006-0	2017	Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration.	Tetradecanoylphorbol Acetate	75-78	thymoma viral proto-oncogene 1	Mus musculus	39-42
28185006-8	2017	Importantly, after overexpression of DKK1, a specific Wnt signaling inhibitor, the accelerated reentry of hair follicles into anagen induced by TPA was abolished.	Tetradecanoylphorbol Acetate	144-147	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	37-41
28185006-9	2017	Our data indicated that TPA-induced hair follicle regeneration is associated with activation of Akt and Wnt/beta-catenin signaling.	Tetradecanoylphorbol Acetate	24-27	thymoma viral proto-oncogene 1	Mus musculus	96-99
28276734-5	2017	In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	149-174	interleukin 1 beta	Homo sapiens	114-136
28276734-5	2017	In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	149-174	interleukin 6	Homo sapiens	141-145
28276734-5	2017	In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	176-179	tumor necrosis factor	Homo sapiens	79-112
28276734-5	2017	In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	176-179	interleukin 1 beta	Homo sapiens	114-136
28276734-5	2017	In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	176-179	interleukin 6	Homo sapiens	141-145
28498408-8	2017	However, subsequent re-stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin resulted in enhanced IL-17 production and expression, particularly in CD4+ surface CXCR3 positive cells.	Tetradecanoylphorbol Acetate	40-71	CD4 molecule	Homo sapiens	162-165
28440421-4	2017	THP-1 cells were exposed to 100 nM phorbol myristate acetate (PMA) for 24 h, and then to oxydized low-density lipoprotein (ox-LDL; 50 mg/ml) to induce foam cell formation.	Tetradecanoylphorbol Acetate	35-60	GLI family zinc finger 2	Homo sapiens	0-5
28498408-8	2017	However, subsequent re-stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin resulted in enhanced IL-17 production and expression, particularly in CD4+ surface CXCR3 positive cells.	Tetradecanoylphorbol Acetate	73-76	CD4 molecule	Homo sapiens	162-165
28440421-4	2017	THP-1 cells were exposed to 100 nM phorbol myristate acetate (PMA) for 24 h, and then to oxydized low-density lipoprotein (ox-LDL; 50 mg/ml) to induce foam cell formation.	Tetradecanoylphorbol Acetate	62-65	GLI family zinc finger 2	Homo sapiens	0-5
27755494-10	2017	Increasing baseline TPA severity was associated with a progressive increase in all regional spinopelvic parameters except thoracic kyphosis, in addition to increased SFA, P Shift, KA, GSA, and C2-C7 lordosis.	Tetradecanoylphorbol Acetate	20-23	GNAS complex locus	Homo sapiens	184-187
27755494-11	2017	As TPA correction increased, there was a reciprocal reduction in SFA, KA, P Shift, GSA, and C2-C7 lordosis.	Tetradecanoylphorbol Acetate	3-6	GNAS complex locus	Homo sapiens	83-86
28235798-4	2017	Incubation of the L-selectin tail with cell extracts from phorbol 12-myristate 13-acetate-stimulated Raw 264.7 macrophages resulted in the binding of mu1A of the clathrin-coated vesicle AP-1 complex.	Tetradecanoylphorbol Acetate	58-89	adaptor related protein complex 1 subunit mu 1	Homo sapiens	150-154
28499422-11	2017	Especially, NFIX was highly expressed in HIV-1 latently infected cell lines and showed a dramatic reduction in expression after phorbol-13-myristate-12-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	161-164	nuclear factor I X	Homo sapiens	12-16
28464033-1	2017	Human lysosomal-associated protein multispanning membrane 5 (LAPTM5) was identified by an ordered differential display-polymerase chain reaction (ODD-PCR) as an up-regulated cDNA fragment during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of U937 cells into monocytes/macrophages.	Tetradecanoylphorbol Acetate	195-231	lysosomal protein transmembrane 5	Homo sapiens	6-59
28464033-1	2017	Human lysosomal-associated protein multispanning membrane 5 (LAPTM5) was identified by an ordered differential display-polymerase chain reaction (ODD-PCR) as an up-regulated cDNA fragment during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of U937 cells into monocytes/macrophages.	Tetradecanoylphorbol Acetate	195-231	lysosomal protein transmembrane 5	Homo sapiens	61-67
28464033-1	2017	Human lysosomal-associated protein multispanning membrane 5 (LAPTM5) was identified by an ordered differential display-polymerase chain reaction (ODD-PCR) as an up-regulated cDNA fragment during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of U937 cells into monocytes/macrophages.	Tetradecanoylphorbol Acetate	233-236	lysosomal protein transmembrane 5	Homo sapiens	6-59
28464033-1	2017	Human lysosomal-associated protein multispanning membrane 5 (LAPTM5) was identified by an ordered differential display-polymerase chain reaction (ODD-PCR) as an up-regulated cDNA fragment during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of U937 cells into monocytes/macrophages.	Tetradecanoylphorbol Acetate	233-236	lysosomal protein transmembrane 5	Homo sapiens	61-67
28464033-2	2017	After TPA-treatment, the levels of LAPTM5 mRNA and protein increased and reached a maximum at 18-36 h. In healthy human tissues, LAPTM5 mRNA was expressed at high levels in hematopoietic cells and tissues, at low levels in the lung and fetal liver, and was not detected in other non-hematopoietic tissues.	Tetradecanoylphorbol Acetate	6-9	lysosomal protein transmembrane 5	Homo sapiens	35-41
28464033-2	2017	After TPA-treatment, the levels of LAPTM5 mRNA and protein increased and reached a maximum at 18-36 h. In healthy human tissues, LAPTM5 mRNA was expressed at high levels in hematopoietic cells and tissues, at low levels in the lung and fetal liver, and was not detected in other non-hematopoietic tissues.	Tetradecanoylphorbol Acetate	6-9	lysosomal protein transmembrane 5	Homo sapiens	129-135
28464033-4	2017	The LAPTM5 level in HL-60 cells increased more significantly during TPA-induced monocyte/macrophage differentiation than during DMSO-induced granulocyte differentiation.	Tetradecanoylphorbol Acetate	68-71	lysosomal protein transmembrane 5	Homo sapiens	4-10
28320863-8	2017	Both basal and phorbol 12-myristate 13-acetate (PMA)-induced NADPH oxidase activity were increased in RacET and correlated positively with 11beta-HSD2 expression (r = 0.788 and r = 0.843, respectively).	Tetradecanoylphorbol Acetate	15-46	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	139-150
28320863-8	2017	Both basal and phorbol 12-myristate 13-acetate (PMA)-induced NADPH oxidase activity were increased in RacET and correlated positively with 11beta-HSD2 expression (r = 0.788 and r = 0.843, respectively).	Tetradecanoylphorbol Acetate	48-51	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	139-150
28415789-5	2017	Ex vivo culture of KCs and development of skin carcinomas in DMBA and TPA mouse models was associated with translocation of the Hmga2 protein from the membrane into the nucleus, where Hmga2 induced its own expression by binding to the Hmga2 promoter.	Tetradecanoylphorbol Acetate	70-73	high mobility group AT-hook 2	Mus musculus	128-133
28415789-5	2017	Ex vivo culture of KCs and development of skin carcinomas in DMBA and TPA mouse models was associated with translocation of the Hmga2 protein from the membrane into the nucleus, where Hmga2 induced its own expression by binding to the Hmga2 promoter.	Tetradecanoylphorbol Acetate	70-73	high mobility group AT-hook 2	Mus musculus	184-189
28415789-5	2017	Ex vivo culture of KCs and development of skin carcinomas in DMBA and TPA mouse models was associated with translocation of the Hmga2 protein from the membrane into the nucleus, where Hmga2 induced its own expression by binding to the Hmga2 promoter.	Tetradecanoylphorbol Acetate	70-73	high mobility group AT-hook 2	Mus musculus	184-189
28389297-4	2017	Accordingly, in HAP1 FBXO25 knockout cells (FBXO25KO), we observed that upon PMA treatment ERK1/2 was more active than in parental cells.	Tetradecanoylphorbol Acetate	77-80	huntingtin associated protein 1	Homo sapiens	16-20
28389297-4	2017	Accordingly, in HAP1 FBXO25 knockout cells (FBXO25KO), we observed that upon PMA treatment ERK1/2 was more active than in parental cells.	Tetradecanoylphorbol Acetate	77-80	mitogen-activated protein kinase 3	Homo sapiens	91-97
28502291-4	2017	Results IM significantly inhibited both mRNA and protein levels of ABIN1 and NF-kappaB, but raised the mRNA and protein levels of A20; while phorbol 12-myristate 13-acetate/ionomycin increased the expression levels of ABIN1 and A20 mRNA and protein.	Tetradecanoylphorbol Acetate	141-172	TNFAIP3 interacting protein 1	Homo sapiens	218-223
28186503-4	2017	We found that following 12-O-tetradecanoyl-phorbol-13-acetate (TPA) topical treatment, DLX3 expression is significantly upregulated in the epidermis and keratinocytes from mice overexpressing PKCalpha by transgenic targeting (K5-PKCalpha), resulting in cell cycle block and terminal differentiation.	Tetradecanoylphorbol Acetate	24-61	protein kinase C, alpha	Mus musculus	192-200
27992687-3	2017	METHODS: Cytokine production by differentiated subsets of CD4+ T cells was assessed by intracellular staining following stimulation with phorbol myristate acetate and ionomycin and by enzyme-linked immunosorbent assay after anti-CD3/anti-CD28 stimulation.	Tetradecanoylphorbol Acetate	137-162	CD4 molecule	Homo sapiens	58-61
28186503-4	2017	We found that following 12-O-tetradecanoyl-phorbol-13-acetate (TPA) topical treatment, DLX3 expression is significantly upregulated in the epidermis and keratinocytes from mice overexpressing PKCalpha by transgenic targeting (K5-PKCalpha), resulting in cell cycle block and terminal differentiation.	Tetradecanoylphorbol Acetate	24-61	protein kinase C, alpha	Mus musculus	229-237
28186503-4	2017	We found that following 12-O-tetradecanoyl-phorbol-13-acetate (TPA) topical treatment, DLX3 expression is significantly upregulated in the epidermis and keratinocytes from mice overexpressing PKCalpha by transgenic targeting (K5-PKCalpha), resulting in cell cycle block and terminal differentiation.	Tetradecanoylphorbol Acetate	63-66	protein kinase C, alpha	Mus musculus	192-200
28186503-4	2017	We found that following 12-O-tetradecanoyl-phorbol-13-acetate (TPA) topical treatment, DLX3 expression is significantly upregulated in the epidermis and keratinocytes from mice overexpressing PKCalpha by transgenic targeting (K5-PKCalpha), resulting in cell cycle block and terminal differentiation.	Tetradecanoylphorbol Acetate	63-66	protein kinase C, alpha	Mus musculus	229-237
28186503-6	2017	Of particular significance, transcriptional activation of epidermal barrier, antimicrobial peptide and cytokine genes is significantly increased in DLX3cKO skin and further increased by TPA-dependent PKC activation.	Tetradecanoylphorbol Acetate	186-189	protein kinase C, alpha	Mus musculus	200-203
28322318-0	2017	12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT.	Tetradecanoylphorbol Acetate	0-36	angiomotin	Homo sapiens	112-116
27400858-8	2017	A complementary ability to enhance TPA-induced AP-1 transcription was observed, even at concentrations insufficient to activate the ERalpha, suggesting a partly independent mechanism.	Tetradecanoylphorbol Acetate	35-38	estrogen receptor 1	Homo sapiens	132-139
28260067-5	2017	These results suggested that Delta19-RhoGDIbeta has an apoptosis-independent role in the PMA-induced differentiation of THP-1 cells to macrophages.	Tetradecanoylphorbol Acetate	89-92	GLI family zinc finger 2	Homo sapiens	120-125
28322318-0	2017	12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT.	Tetradecanoylphorbol Acetate	38-41	angiomotin	Homo sapiens	112-116
28322318-4	2017	The inhibitory effects of TPA on YAP were AMOT dependent.	Tetradecanoylphorbol Acetate	26-29	angiomotin	Homo sapiens	42-46
28322318-6	2017	Importantly, the depletion of YAP and AMOT blocked the TPA-reduced transformative phenotypes.	Tetradecanoylphorbol Acetate	55-58	angiomotin	Homo sapiens	38-42
28322318-7	2017	In sum, TPA has been established as an anti-tumorigenic drug in liver cancer cells via YAP and AMOT.	Tetradecanoylphorbol Acetate	8-11	angiomotin	Homo sapiens	95-99
28322331-6	2017	Western blot analysis showed that both phosphorylated STAT3 and phosphorylated AKT expressions were significantly increased in epidermis of TC-PTP-deficient mice compared to control mice following TPA treatment.	Tetradecanoylphorbol Acetate	197-200	signal transducer and activator of transcription 3	Mus musculus	54-59
28322331-6	2017	Western blot analysis showed that both phosphorylated STAT3 and phosphorylated AKT expressions were significantly increased in epidermis of TC-PTP-deficient mice compared to control mice following TPA treatment.	Tetradecanoylphorbol Acetate	197-200	thymoma viral proto-oncogene 1	Mus musculus	79-82
27576126-8	2017	Moreover, ILC2s expressed CD154 in response to phorbol 12-myristate 13-acetate plus ionomycin, IL-25/IL-33, or a mixture of TLR ligands.	Tetradecanoylphorbol Acetate	47-78	CD40 ligand	Homo sapiens	26-31
28286024-2	2017	In MEFs, activation of ERK by TPA stimulation induced a common pattern of H3K9acS10ph, H4K16ac, H3K27ac, H3K9acK14ac, and H3K4me3 at hundreds of transcription start site (TSS) regions and remote regulatory sites.	Tetradecanoylphorbol Acetate	30-33	mitogen-activated protein kinase 1	Homo sapiens	23-26
28167257-6	2017	Tetradecanol decreased PMA/Io-induced promoter activity of NF-kappaB in EL-4 T cells, but did not show any significant effects on the promoters of activator protein 1 (AP-1) and nuclear factor of activated T cells (NF-AT).	Tetradecanoylphorbol Acetate	23-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	59-68
28119118-5	2017	We observed that stimulator of interferon genes (STING) limited HTLV-1 protein expression and was critical to HTLV-1 reverse transcription intermediate (RTI) ssDNA90 triggered interferon (IFN)-beta production in phorbol12-myristate13-acetate (PMA)-differentiated THP1 (PMA-THP1) cells.	Tetradecanoylphorbol Acetate	212-241	GLI family zinc finger 2	Homo sapiens	263-267
28119118-5	2017	We observed that stimulator of interferon genes (STING) limited HTLV-1 protein expression and was critical to HTLV-1 reverse transcription intermediate (RTI) ssDNA90 triggered interferon (IFN)-beta production in phorbol12-myristate13-acetate (PMA)-differentiated THP1 (PMA-THP1) cells.	Tetradecanoylphorbol Acetate	212-241	GLI family zinc finger 2	Homo sapiens	269-277
28351321-0	2017	Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells.	Tetradecanoylphorbol Acetate	159-184	mechanistic target of rapamycin kinase	Homo sapiens	0-29
27923483-10	2017	Treatment with PMA induced MT1-MMP-GFP internalization, enhanced phospho-Smad2, and reduced MMP-2 activation, whereas rottlerin pretreatment inhibited these effects.	Tetradecanoylphorbol Acetate	15-18	SMAD family member 2	Mus musculus	73-78
28097492-9	2017	TRPM2 and TRPV1 currents were increased by the PKC activator, phorbol myristate acetate (PMA), although the currents were decreased by ACA, CPZ, and the PKC inhibitor, bisindolylmaleimide I (BIM).	Tetradecanoylphorbol Acetate	62-87	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	0-5
28097492-9	2017	TRPM2 and TRPV1 currents were increased by the PKC activator, phorbol myristate acetate (PMA), although the currents were decreased by ACA, CPZ, and the PKC inhibitor, bisindolylmaleimide I (BIM).	Tetradecanoylphorbol Acetate	89-92	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	0-5
27538486-7	2017	In non-Hodgkin B-cell lines, small interfering RNA-mediated PDLIM2 knockdown results in superactivation of TFs NF-kappaB and AP-1 following phorbol 12-myristate 13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	140-171	PDZ and LIM domain 2	Homo sapiens	60-66
27538486-7	2017	In non-Hodgkin B-cell lines, small interfering RNA-mediated PDLIM2 knockdown results in superactivation of TFs NF-kappaB and AP-1 following phorbol 12-myristate 13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	140-171	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	125-129
27538486-7	2017	In non-Hodgkin B-cell lines, small interfering RNA-mediated PDLIM2 knockdown results in superactivation of TFs NF-kappaB and AP-1 following phorbol 12-myristate 13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	173-176	PDZ and LIM domain 2	Homo sapiens	60-66
28351321-4	2017	We recently reported that mammalian target of rapamycin inhibitors-rapamycin, temsirolimus, torin 1, and PP242-suppressed invasion and migration promoted by tumor necrosis factor-alpha and phorbol-myristate-acetate in glioblastoma cells.	Tetradecanoylphorbol Acetate	189-214	mechanistic target of rapamycin kinase	Homo sapiens	26-55
28351321-6	2017	We demonstrate that temsirolimus and torin 1 effectively reduced the constitutive as well as phorbol-myristate-acetate/oncostatin-M-induced expression of mesenchymal markers (fibronectin, vimentin, and YKL40) and neural stem cell markers (Sox2, Oct4, nestin, and mushashi1).	Tetradecanoylphorbol Acetate	93-118	fibronectin 1	Homo sapiens	175-186
28166796-5	2017	Chemically-induced Gaucher macrophages were developed by differentiateing THP-1 monocytes to macrophages by treatment with phorbol 12-myristate 13-acetate (PMA) and then inhibiting intracellular GCase with conduritol B-epoxide (CBE), a specific irreversible inhibitor of GCase activity, and supplementing the medium with exogenous GlcCer.	Tetradecanoylphorbol Acetate	123-154	GLI family zinc finger 2	Homo sapiens	74-79
28108223-8	2017	Furthermore, morusin inhibited the TPA upregulation of cyclooxygenase 2 (COX-2), which may be regulated by AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	35-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	55-71
28108223-8	2017	Furthermore, morusin inhibited the TPA upregulation of cyclooxygenase 2 (COX-2), which may be regulated by AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	35-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	73-78
28108223-8	2017	Furthermore, morusin inhibited the TPA upregulation of cyclooxygenase 2 (COX-2), which may be regulated by AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	35-38	nuclear factor kappa B subunit 1	Homo sapiens	116-125
30650487-2	2017	Methods Human acute leukemia mononuclear strain THP-1 was induced to become TAMs using Phorbol-12-myristate-13-acetate (PMA) combined IL-4 and IL- 13.	Tetradecanoylphorbol Acetate	87-118	GLI family zinc finger 2	Homo sapiens	48-53
30650487-2	2017	Methods Human acute leukemia mononuclear strain THP-1 was induced to become TAMs using Phorbol-12-myristate-13-acetate (PMA) combined IL-4 and IL- 13.	Tetradecanoylphorbol Acetate	120-123	GLI family zinc finger 2	Homo sapiens	48-53
28108223-7	2017	Moreover, morusin inhibited TPA-induced activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) activation, which can mediate cell proliferation and malignant transformation.	Tetradecanoylphorbol Acetate	28-31	nuclear factor kappa B subunit 1	Homo sapiens	95-104
28008134-8	2017	Activating PKC-alpha and EGFR directly with the combination of phorbol 12-myristate 13-acetate (PMA) and EGF potentiated MMP1 gene and protein expression, and cell invasion.	Tetradecanoylphorbol Acetate	63-94	protein kinase C alpha	Homo sapiens	11-20
28008134-8	2017	Activating PKC-alpha and EGFR directly with the combination of phorbol 12-myristate 13-acetate (PMA) and EGF potentiated MMP1 gene and protein expression, and cell invasion.	Tetradecanoylphorbol Acetate	63-94	epidermal growth factor receptor	Homo sapiens	25-29
28166796-5	2017	Chemically-induced Gaucher macrophages were developed by differentiateing THP-1 monocytes to macrophages by treatment with phorbol 12-myristate 13-acetate (PMA) and then inhibiting intracellular GCase with conduritol B-epoxide (CBE), a specific irreversible inhibitor of GCase activity, and supplementing the medium with exogenous GlcCer.	Tetradecanoylphorbol Acetate	156-159	GLI family zinc finger 2	Homo sapiens	74-79
28052562-5	2017	By using the phorbol 12-myristate 13-acetate-induced cell differentiation model, we found that caspase-1 activation was required for the differentiation of human monocytes to macrophages.	Tetradecanoylphorbol Acetate	13-44	caspase 1	Homo sapiens	95-104
27863334-7	2017	Conversely, in phorbol 12-myristate 13-acetate and ionomycin (PMA/Io) stimulated Caco-2 cells, lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8.	Tetradecanoylphorbol Acetate	15-46	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
27863334-7	2017	Conversely, in phorbol 12-myristate 13-acetate and ionomycin (PMA/Io) stimulated Caco-2 cells, lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8.	Tetradecanoylphorbol Acetate	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
28103717-7	2017	The results showed that cells stimulated with PMA/ionomycin (activators of PKC) showed significantly increased reactive oxygen species production, and this production returned to baseline levels after treatment with DPI (NOX inhibitor).	Tetradecanoylphorbol Acetate	46-49	proline rich transmembrane protein 2	Homo sapiens	75-78
26991747-1	2017	OBJECTIVES: The impact of ischemic stroke subtype on clinical outcome in patients treated with intravenous tissue-type plasminogen activator (IV-tPA) is sparsely examined.	Tetradecanoylphorbol Acetate	145-148	plasminogen activator, tissue type	Homo sapiens	107-140
28062212-7	2017	Further investigation revealed that either rescue expression of CD147 or treatment of MAPK/ERK activator phorbol 12-myristate 13-acetate (PMA) in CD147 knockdown CRC cell line attenuated the decreased chemoresistance in CD147 knockdown cells.	Tetradecanoylphorbol Acetate	105-136	mitogen-activated protein kinase 1	Homo sapiens	86-90
28062212-7	2017	Further investigation revealed that either rescue expression of CD147 or treatment of MAPK/ERK activator phorbol 12-myristate 13-acetate (PMA) in CD147 knockdown CRC cell line attenuated the decreased chemoresistance in CD147 knockdown cells.	Tetradecanoylphorbol Acetate	105-136	mitogen-activated protein kinase 1	Homo sapiens	91-94
28062212-7	2017	Further investigation revealed that either rescue expression of CD147 or treatment of MAPK/ERK activator phorbol 12-myristate 13-acetate (PMA) in CD147 knockdown CRC cell line attenuated the decreased chemoresistance in CD147 knockdown cells.	Tetradecanoylphorbol Acetate	138-141	mitogen-activated protein kinase 1	Homo sapiens	86-90
28062212-7	2017	Further investigation revealed that either rescue expression of CD147 or treatment of MAPK/ERK activator phorbol 12-myristate 13-acetate (PMA) in CD147 knockdown CRC cell line attenuated the decreased chemoresistance in CD147 knockdown cells.	Tetradecanoylphorbol Acetate	138-141	mitogen-activated protein kinase 1	Homo sapiens	91-94
28035371-4	2017	In ER-positive MCF-7 cells, arctigenin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell migration and invasion.	Tetradecanoylphorbol Acetate	99-102	estrogen receptor 1	Homo sapiens	3-5
28060219-1	2017	BACKGROUND AND PURPOSE: The approved treatment by the Food and Drug Administration for acute ischemic stroke is intravenous tissue-type plasminogen activator (IV tPA).	Tetradecanoylphorbol Acetate	162-165	plasminogen activator, tissue type	Homo sapiens	124-157
28028150-1	2017	BACKGROUND AND PURPOSE: Clinical trials have demonstrated improved 90-day outcomes for patients with acute ischemic stroke treated with stent retriever thrombectomy plus tissue-type plasminogen activator (SST+tPA) compared with tPA.	Tetradecanoylphorbol Acetate	209-212	plasminogen activator, tissue type	Homo sapiens	170-203
28160867-3	2017	PURPOSE: This study focused on assessing the anti-inflammatory effects of fargesin on phorbal ester (PMA)-stimulated THP-1 human monocytes, and the molecular mechanisms underlying them.	Tetradecanoylphorbol Acetate	101-104	GLI family zinc finger 2	Homo sapiens	117-122
28286738-4	2017	Treatment with phorbol-12-myristate-13-acetate (PMA), a potent agonist of protein kinase C (PKC) and its downstream effector in the MEK/ERK-dependent pathway, resulted in the activation of mTORC1 signaling and phosphorylation of the upstream regulator tuberous sclerosis 2 (TSC2) in C2C12 myoblasts.	Tetradecanoylphorbol Acetate	15-46	mitogen-activated protein kinase kinase 7	Homo sapiens	132-135
28286738-4	2017	Treatment with phorbol-12-myristate-13-acetate (PMA), a potent agonist of protein kinase C (PKC) and its downstream effector in the MEK/ERK-dependent pathway, resulted in the activation of mTORC1 signaling and phosphorylation of the upstream regulator tuberous sclerosis 2 (TSC2) in C2C12 myoblasts.	Tetradecanoylphorbol Acetate	15-46	mitogen-activated protein kinase 1	Homo sapiens	136-139
28286738-4	2017	Treatment with phorbol-12-myristate-13-acetate (PMA), a potent agonist of protein kinase C (PKC) and its downstream effector in the MEK/ERK-dependent pathway, resulted in the activation of mTORC1 signaling and phosphorylation of the upstream regulator tuberous sclerosis 2 (TSC2) in C2C12 myoblasts.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase kinase 7	Homo sapiens	132-135
28286738-4	2017	Treatment with phorbol-12-myristate-13-acetate (PMA), a potent agonist of protein kinase C (PKC) and its downstream effector in the MEK/ERK-dependent pathway, resulted in the activation of mTORC1 signaling and phosphorylation of the upstream regulator tuberous sclerosis 2 (TSC2) in C2C12 myoblasts.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 1	Homo sapiens	136-139
28286738-5	2017	PMA-induced activation of mTORC1 signaling was partially prevented by treatment with U0126 (a selective inhibitor of MEK1/2) or BIX-02189 (a selective inhibitor of MEK5) and completely blocked with BIM-I (a selective inhibitor of upstream PKC).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 5	Homo sapiens	164-168
28286738-6	2017	TSC2 phosphorylation at Ser664 (an ERK-dependent phosphorylation site) was prevented with U0126, and BIM-I treatment blocked PMA-induced phosphorylation of TSC2 at multiple residues (Ser664, Ser939, and Thr1462).	Tetradecanoylphorbol Acetate	125-128	mitogen-activated protein kinase 1	Homo sapiens	35-38
28073348-15	2017	CONCLUSION: The present data reveal that F2 fraction has a remarkable antitumor activity against DMBA/TPA-induced skin carcinogenesis, an effect that may be mediated through inhibition of the MAPK/ERK and PI3K/AKT pathways.	Tetradecanoylphorbol Acetate	102-105	mitogen-activated protein kinase 1	Homo sapiens	192-196
27393705-7	2017	Del treatment of interleukin-22 or TPA-stimulated normal human epidermal keratinocytes (NHEKs) significantly inhibited proliferation, activation of PI3K/Akt/mTOR components, and secretion of proinflammatory cytokines and chemokines.	Tetradecanoylphorbol Acetate	35-38	AKT serine/threonine kinase 1	Homo sapiens	153-156
27393705-7	2017	Del treatment of interleukin-22 or TPA-stimulated normal human epidermal keratinocytes (NHEKs) significantly inhibited proliferation, activation of PI3K/Akt/mTOR components, and secretion of proinflammatory cytokines and chemokines.	Tetradecanoylphorbol Acetate	35-38	mechanistic target of rapamycin kinase	Homo sapiens	157-161
28073348-15	2017	CONCLUSION: The present data reveal that F2 fraction has a remarkable antitumor activity against DMBA/TPA-induced skin carcinogenesis, an effect that may be mediated through inhibition of the MAPK/ERK and PI3K/AKT pathways.	Tetradecanoylphorbol Acetate	102-105	mitogen-activated protein kinase 1	Homo sapiens	197-200
28073348-15	2017	CONCLUSION: The present data reveal that F2 fraction has a remarkable antitumor activity against DMBA/TPA-induced skin carcinogenesis, an effect that may be mediated through inhibition of the MAPK/ERK and PI3K/AKT pathways.	Tetradecanoylphorbol Acetate	102-105	AKT serine/threonine kinase 1	Homo sapiens	210-213
28849482-8	2017	In particular, PMA-stimulated neutrophils showed high level of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) expression compared to the level of the same glycolytic enzyme in the resting neutrophils.	Tetradecanoylphorbol Acetate	15-18	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	63-103
27871911-5	2017	In addition, we also showed that theaflavin-3,3"-digallate inhibited the expression of tumor necrosis factor alpha, interleukin -1 beta, and interleukin 6 in phorbol myristate acetate -primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	158-183	tumor necrosis factor	Homo sapiens	87-114
27871911-5	2017	In addition, we also showed that theaflavin-3,3"-digallate inhibited the expression of tumor necrosis factor alpha, interleukin -1 beta, and interleukin 6 in phorbol myristate acetate -primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	158-183	interleukin 1 beta	Homo sapiens	116-135
27871911-5	2017	In addition, we also showed that theaflavin-3,3"-digallate inhibited the expression of tumor necrosis factor alpha, interleukin -1 beta, and interleukin 6 in phorbol myristate acetate -primed U937 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	158-183	interleukin 6	Homo sapiens	141-154
27810601-0	2017	Differential roles of PKC isoforms (PKCs) and Ca2+ in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells.	Tetradecanoylphorbol Acetate	63-94	protein kinase C, alpha	Mus musculus	22-25
27810601-0	2017	Differential roles of PKC isoforms (PKCs) and Ca2+ in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells.	Tetradecanoylphorbol Acetate	96-99	protein kinase C, alpha	Mus musculus	22-25
28849482-8	2017	In particular, PMA-stimulated neutrophils showed high level of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) expression compared to the level of the same glycolytic enzyme in the resting neutrophils.	Tetradecanoylphorbol Acetate	15-18	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	105-110
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	111-114	mitotic spindle positioning	Homo sapiens	200-204
27816791-7	2017	METHODS: M1- and M2-like Mphis were generated in vitro from the THP-1 monocyte cell line by differentiation with PMA and Vitamin D3, respectively.	Tetradecanoylphorbol Acetate	113-116	GLI family zinc finger 2	Homo sapiens	64-69
29098164-8	2017	We found that MISP, KLF10, KLF15, PPP1R18, and RXRbeta proteins could strongly respond to TPA stimulation and activate LCN2 transcriptional expression.	Tetradecanoylphorbol Acetate	90-93	mitotic spindle positioning	Homo sapiens	14-18
28053321-3	2017	The functionality of these IL4 haplotypes in the response of immune cells to phorbol 12-myristate 13-acetate (PMA) with Ionomycin and IL-1beta (as inflammatory stimuli) was evaluated.	Tetradecanoylphorbol Acetate	77-108	interleukin 4	Homo sapiens	27-30
28053321-3	2017	The functionality of these IL4 haplotypes in the response of immune cells to phorbol 12-myristate 13-acetate (PMA) with Ionomycin and IL-1beta (as inflammatory stimuli) was evaluated.	Tetradecanoylphorbol Acetate	110-113	interleukin 4	Homo sapiens	27-30
27815388-8	2017	Zbtb4-/- mice were also more susceptible to 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA)-induced skin carcinogenesis.	Tetradecanoylphorbol Acetate	75-111	zinc finger and BTB domain containing 4	Mus musculus	0-5
27815388-8	2017	Zbtb4-/- mice were also more susceptible to 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA)-induced skin carcinogenesis.	Tetradecanoylphorbol Acetate	118-121	zinc finger and BTB domain containing 4	Mus musculus	0-5
29045950-3	2017	METHODS: Human THP-1 cells were fully differentiated into foam cells by the pre-treatment with phorbol-12-myristate-13-acetate (PMA) and oxidized density lipoproteins (ox-LDL).	Tetradecanoylphorbol Acetate	95-126	GLI family zinc finger 2	Homo sapiens	15-20
29045950-3	2017	METHODS: Human THP-1 cells were fully differentiated into foam cells by the pre-treatment with phorbol-12-myristate-13-acetate (PMA) and oxidized density lipoproteins (ox-LDL).	Tetradecanoylphorbol Acetate	128-131	GLI family zinc finger 2	Homo sapiens	15-20
29142175-4	2017	Pulldown assay showed that the activation of RhoA was obviously enhanced when U937 cells were treated with PMA.	Tetradecanoylphorbol Acetate	107-110	ras homolog family member A	Homo sapiens	45-49
27810232-0	2017	Potential role of IL-17-producing CD4/CD8 double negative alphabeta T cells in psoriatic skin inflammation in a TPA-induced STAT3C transgenic mouse model.	Tetradecanoylphorbol Acetate	112-115	signal transducer and activator of transcription 3	Mus musculus	124-129
27932441-13	2017	MAIN RESULTS AND THE ROLE OF CHANCE: Trophoblast CM and 10 nM VIP promoted neutrophil deactivation by preventing phorbol myristate acetate-induced NET formation and ROS synthesis while they increased neutrophil spontaneous apoptosis and reversed the anti-apoptotic effect of lipopolysaccharide (all P &lt; 0.05 versus control).	Tetradecanoylphorbol Acetate	113-138	vasoactive intestinal peptide	Homo sapiens	62-65
28123548-0	2017	DHA blocks TPA-induced cell invasion by inhibiting MMP-9 expression via suppression of the PPAR-gamma/NF-kappaB pathway in MCF-7 cells.	Tetradecanoylphorbol Acetate	11-14	peroxisome proliferator activated receptor gamma	Homo sapiens	91-101
27778136-0	2017	Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells.	Tetradecanoylphorbol Acetate	28-59	sterol regulatory element binding transcription factor 2	Homo sapiens	68-75
27778136-6	2017	The processing of SREBP-2 protein was promoted by phorbol 12-myristate 13-acetate (PMA) in the hepatic cells WRL and HepG2, and the increased processing was reversed by apigenin or luteolin co-administration.	Tetradecanoylphorbol Acetate	50-81	sterol regulatory element binding transcription factor 2	Homo sapiens	18-25
27778136-6	2017	The processing of SREBP-2 protein was promoted by phorbol 12-myristate 13-acetate (PMA) in the hepatic cells WRL and HepG2, and the increased processing was reversed by apigenin or luteolin co-administration.	Tetradecanoylphorbol Acetate	83-86	sterol regulatory element binding transcription factor 2	Homo sapiens	18-25
28123548-5	2017	DHA inhibited the TPA-induced activation of mitogen-activated protein kinase (MAPK) and the transcription of nuclear factor (NF)-kappaB, but did not inhibit the transcription of activator protein-1.	Tetradecanoylphorbol Acetate	18-21	nuclear factor kappa B subunit 1	Homo sapiens	109-135
28119748-5	2017	METHODS: Effects of MF and budesonide (BUD) on the phorbol-12-myristate-13-acetate (PMA)-induction of mucin and TNF-alpha in human airway epithelial cells (NCI-H292) were investigated in the present study.	Tetradecanoylphorbol Acetate	51-82	tumor necrosis factor	Homo sapiens	112-121
28119748-5	2017	METHODS: Effects of MF and budesonide (BUD) on the phorbol-12-myristate-13-acetate (PMA)-induction of mucin and TNF-alpha in human airway epithelial cells (NCI-H292) were investigated in the present study.	Tetradecanoylphorbol Acetate	84-87	tumor necrosis factor	Homo sapiens	112-121
27732902-9	2016	Furthermore, TPA application had resulted in the up-regulation of TNF-alpha gene expression by 353-fold, which was subsequently down-regulated by the Haruan cream (34- to 112-fold).	Tetradecanoylphorbol Acetate	13-16	tumor necrosis factor	Mus musculus	66-75
29911380-5	2017	Compared to the vehicle-treated group, PMA statistically decreased P-gp luciferase activity, mRNA expression and protein expression.	Tetradecanoylphorbol Acetate	39-42	ATP binding cassette subfamily B member 1	Homo sapiens	67-71
29911380-8	2017	In addition, knockdown of PKCalpha, NF-kappaB or PXR can significantly attenuate PMA-induced P-gp suppression.	Tetradecanoylphorbol Acetate	81-84	protein kinase C alpha	Homo sapiens	26-34
29911380-8	2017	In addition, knockdown of PKCalpha, NF-kappaB or PXR can significantly attenuate PMA-induced P-gp suppression.	Tetradecanoylphorbol Acetate	81-84	nuclear factor kappa B subunit 1	Homo sapiens	36-45
29911380-8	2017	In addition, knockdown of PKCalpha, NF-kappaB or PXR can significantly attenuate PMA-induced P-gp suppression.	Tetradecanoylphorbol Acetate	81-84	nuclear receptor subfamily 1 group I member 2	Homo sapiens	49-52
29911380-8	2017	In addition, knockdown of PKCalpha, NF-kappaB or PXR can significantly attenuate PMA-induced P-gp suppression.	Tetradecanoylphorbol Acetate	81-84	ATP binding cassette subfamily B member 1	Homo sapiens	93-97
27910925-7	2016	TM siRNA depressed the PMA-induced increase of p21Cip1/WAF1 via ERK1/2-NF-kB p65 signaling.	Tetradecanoylphorbol Acetate	23-26	cyclin dependent kinase inhibitor 1A	Homo sapiens	55-59
27994457-5	2016	PMA treatment also significantly increased the traction of THP1 cells on bovine serum albumin proteins, although the effect on K562 cells was insignificant.	Tetradecanoylphorbol Acetate	0-3	GLI family zinc finger 2	Homo sapiens	59-63
27910925-5	2016	First, we found that TM was increased when THP-1 cells were treated with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	73-104	GLI family zinc finger 2	Homo sapiens	43-48
28004780-5	2016	Restored TG1 expression of EGF-stimulated differentiated Adam17-/- keratinocytes was strongly repressed by inhibitors for PLCgamma1 or protein kinase C (PKC) pathways, while treatment with the PKC stimulator 12-O-tetradecanoylphorbol-13-acetate restored TG activity in the epidermis of keratinocyte-specific Adam17-/- (AD17DeltaKC) mice.	Tetradecanoylphorbol Acetate	208-244	triglyceride level 1	Mus musculus	9-12
28004780-5	2016	Restored TG1 expression of EGF-stimulated differentiated Adam17-/- keratinocytes was strongly repressed by inhibitors for PLCgamma1 or protein kinase C (PKC) pathways, while treatment with the PKC stimulator 12-O-tetradecanoylphorbol-13-acetate restored TG activity in the epidermis of keratinocyte-specific Adam17-/- (AD17DeltaKC) mice.	Tetradecanoylphorbol Acetate	208-244	a disintegrin and metallopeptidase domain 17	Mus musculus	57-63
27867007-3	2016	We show that, in MEFs, TCF inactivation significantly inhibits over 60% of TPA-inducible gene transcription and impairs cell proliferation.	Tetradecanoylphorbol Acetate	75-78	hepatocyte nuclear factor 4 alpha	Homo sapiens	23-26
27910925-5	2016	First, we found that TM was increased when THP-1 cells were treated with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	106-109	GLI family zinc finger 2	Homo sapiens	43-48
27910925-7	2016	TM siRNA depressed the PMA-induced increase of p21Cip1/WAF1 via ERK1/2-NF-kB p65 signaling.	Tetradecanoylphorbol Acetate	23-26	mitogen-activated protein kinase 3	Homo sapiens	64-70
27910925-7	2016	TM siRNA depressed the PMA-induced increase of p21Cip1/WAF1 via ERK1/2-NF-kB p65 signaling.	Tetradecanoylphorbol Acetate	23-26	cyclin dependent kinase inhibitor 1A	Homo sapiens	47-54
27910925-9	2016	In addition, PMA-induced p21Cip1/WAF1 expression, CD14-positive cell labeling intensity and ERK1/2 phosphorylation were markedly inhibited when protein kinase C-delta (PKCdelta) was knocked down.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	25-32
27910925-9	2016	In addition, PMA-induced p21Cip1/WAF1 expression, CD14-positive cell labeling intensity and ERK1/2 phosphorylation were markedly inhibited when protein kinase C-delta (PKCdelta) was knocked down.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	33-37
27910925-9	2016	In addition, PMA-induced p21Cip1/WAF1 expression, CD14-positive cell labeling intensity and ERK1/2 phosphorylation were markedly inhibited when protein kinase C-delta (PKCdelta) was knocked down.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 3	Homo sapiens	92-98
27793942-7	2016	We assessed JuSt-23F-mediated phosphorylation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in T-cell lymphoma and MCL cells stimulated by phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	156-187	mitogen-activated protein kinase 1	Homo sapiens	53-99
27901058-9	2016	Furthermore, using capacitated sperm we found that cAMP reduced PMA-induced ERK1/2 activation and acrosome reaction.	Tetradecanoylphorbol Acetate	64-67	cathelicidin antimicrobial peptide	Homo sapiens	51-55
27901058-9	2016	Furthermore, using capacitated sperm we found that cAMP reduced PMA-induced ERK1/2 activation and acrosome reaction.	Tetradecanoylphorbol Acetate	64-67	mitogen-activated protein kinase 3	Homo sapiens	76-82
28105139-4	2016	Phorbol 12-myristate 13-acetate-stimulated THP-1 cells were treated with oxidized low-density lipoprotein and (3H)-cholesterol for 24 h, and the effects of baicalin on cholesterol efflux were evaluated in the presence of apolipoprotein A-1 (ApoA-1), or high-density lipoprotein subfraction 2 (HDL2) or subfraction 3 (HDL3).	Tetradecanoylphorbol Acetate	0-31	GLI family zinc finger 2	Homo sapiens	43-48
28105139-4	2016	Phorbol 12-myristate 13-acetate-stimulated THP-1 cells were treated with oxidized low-density lipoprotein and (3H)-cholesterol for 24 h, and the effects of baicalin on cholesterol efflux were evaluated in the presence of apolipoprotein A-1 (ApoA-1), or high-density lipoprotein subfraction 2 (HDL2) or subfraction 3 (HDL3).	Tetradecanoylphorbol Acetate	0-31	apolipoprotein A1	Homo sapiens	221-239
28105139-4	2016	Phorbol 12-myristate 13-acetate-stimulated THP-1 cells were treated with oxidized low-density lipoprotein and (3H)-cholesterol for 24 h, and the effects of baicalin on cholesterol efflux were evaluated in the presence of apolipoprotein A-1 (ApoA-1), or high-density lipoprotein subfraction 2 (HDL2) or subfraction 3 (HDL3).	Tetradecanoylphorbol Acetate	0-31	apolipoprotein A1	Homo sapiens	241-247
28105139-4	2016	Phorbol 12-myristate 13-acetate-stimulated THP-1 cells were treated with oxidized low-density lipoprotein and (3H)-cholesterol for 24 h, and the effects of baicalin on cholesterol efflux were evaluated in the presence of apolipoprotein A-1 (ApoA-1), or high-density lipoprotein subfraction 2 (HDL2) or subfraction 3 (HDL3).	Tetradecanoylphorbol Acetate	0-31	HDL3	Homo sapiens	317-321
27138049-3	2016	The assay employed a model of the human monocyte cell line U937 stimulated with lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA) for the release of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6.	Tetradecanoylphorbol Acetate	109-140	tumor necrosis factor	Homo sapiens	166-199
27138049-3	2016	The assay employed a model of the human monocyte cell line U937 stimulated with lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA) for the release of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6.	Tetradecanoylphorbol Acetate	109-140	interleukin 6	Homo sapiens	204-222
27793942-7	2016	We assessed JuSt-23F-mediated phosphorylation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in T-cell lymphoma and MCL cells stimulated by phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	156-187	mitogen-activated protein kinase 3	Homo sapiens	101-107
27793942-7	2016	We assessed JuSt-23F-mediated phosphorylation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in T-cell lymphoma and MCL cells stimulated by phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	189-192	mitogen-activated protein kinase 1	Homo sapiens	53-99
27793942-7	2016	We assessed JuSt-23F-mediated phosphorylation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in T-cell lymphoma and MCL cells stimulated by phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	189-192	mitogen-activated protein kinase 3	Homo sapiens	101-107
27374227-8	2016	Inhibition of ERK/MAPK pathway with PD98059 potently blocked N2a cell neurite outgrowth, whereas phorbol 12-myristate 13-acetate-induced ERK activation rescued defects in neurite outgrowth and cell death induced by Malat1 depletion.	Tetradecanoylphorbol Acetate	97-128	mitogen-activated protein kinase 1	Mus musculus	137-140
27647370-5	2016	This compound exhibits potent inhibitory activity toward IL-2 release in both 12-o-tetradecanoylphorbol-13-acetate (PMA)/A23187 (ionomycin) (IC50=80+-10nM) and anti-CD3/CD28-stimulated Jurkat T cells (83% inhibition at 10muM) without cytotoxic effects.	Tetradecanoylphorbol Acetate	78-114	interleukin 2	Homo sapiens	57-61
27647370-5	2016	This compound exhibits potent inhibitory activity toward IL-2 release in both 12-o-tetradecanoylphorbol-13-acetate (PMA)/A23187 (ionomycin) (IC50=80+-10nM) and anti-CD3/CD28-stimulated Jurkat T cells (83% inhibition at 10muM) without cytotoxic effects.	Tetradecanoylphorbol Acetate	116-119	interleukin 2	Homo sapiens	57-61
27464529-9	2016	Inhibition of Wnt/beta-catenin signaling by injecting Dickkopf1 plasmids into TPA-treated skin decreased hair matrix pigmentation and inhibited the proliferation and differentiation of McSCs.	Tetradecanoylphorbol Acetate	78-81	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	54-63
27680589-5	2016	Compound 4 pretreatment resulted in markedly suppression of TPA-induced IL-1beta, IL-6, TNF-alpha, and COX-2, respectively.	Tetradecanoylphorbol Acetate	60-63	interleukin 1 beta	Mus musculus	72-80
27680589-5	2016	Compound 4 pretreatment resulted in markedly suppression of TPA-induced IL-1beta, IL-6, TNF-alpha, and COX-2, respectively.	Tetradecanoylphorbol Acetate	60-63	interleukin 6	Mus musculus	82-86
27680589-5	2016	Compound 4 pretreatment resulted in markedly suppression of TPA-induced IL-1beta, IL-6, TNF-alpha, and COX-2, respectively.	Tetradecanoylphorbol Acetate	60-63	tumor necrosis factor	Mus musculus	88-97
27693888-6	2016	The highest dose cohorts demonstrated sustained inhibition of extracellular signal-regulated kinase (ERK) phosphorylation in peripheral blood mononuclear cells following ex-vivo phorbol 12-myristate 13-acetate stimulation.	Tetradecanoylphorbol Acetate	178-209	mitogen-activated protein kinase 1	Homo sapiens	62-99
27693888-6	2016	The highest dose cohorts demonstrated sustained inhibition of extracellular signal-regulated kinase (ERK) phosphorylation in peripheral blood mononuclear cells following ex-vivo phorbol 12-myristate 13-acetate stimulation.	Tetradecanoylphorbol Acetate	178-209	mitogen-activated protein kinase 1	Homo sapiens	101-104
27777559-2	2016	This study aimed to assess the effects of curcumin on NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages and explore its underlying mechanism.	Tetradecanoylphorbol Acetate	76-107	NLR family pyrin domain containing 3	Homo sapiens	54-59
27777559-2	2016	This study aimed to assess the effects of curcumin on NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages and explore its underlying mechanism.	Tetradecanoylphorbol Acetate	109-112	NLR family pyrin domain containing 3	Homo sapiens	54-59
27777559-5	2016	Results: Curcumin significantly reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	116-119	caspase 1	Homo sapiens	80-89
27777559-0	2016	Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-kappaB and P2X7R Signaling in PMA-Induced Macrophages.	Tetradecanoylphorbol Acetate	97-100	NLR family pyrin domain containing 3	Homo sapiens	19-24
27777559-5	2016	Results: Curcumin significantly reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	116-119	interleukin 1 beta	Homo sapiens	94-102
27777559-9	2016	Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion.	Tetradecanoylphorbol Acetate	31-34	NLR family pyrin domain containing 3	Homo sapiens	104-109
27777559-9	2016	Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion.	Tetradecanoylphorbol Acetate	31-34	caspase 1	Homo sapiens	126-135
27777559-9	2016	Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion.	Tetradecanoylphorbol Acetate	31-34	interleukin 1 beta	Homo sapiens	140-148
27777559-11	2016	Conclusion: Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	113-116	NLR family pyrin domain containing 3	Homo sapiens	31-36
27777559-11	2016	Conclusion: Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	113-116	nuclear factor kappa B subunit 1	Homo sapiens	81-90
27598116-5	2016	IL-6 levels in the HMC-1 stimulated by phorbol-12-myristate-13-acetate and A23187 were apparently decreased by the treatment of atractylodin.	Tetradecanoylphorbol Acetate	39-70	interleukin 6	Homo sapiens	0-4
27708396-3	2016	Here, we demonstrate that ERK/c-Jun signaling is involved in DNA demethylation of EBV immediate early (IE) gene Zta in response to 12-O-Tetradecanoylphorbol-13-acetate (TPA) stimulation.	Tetradecanoylphorbol Acetate	131-167	mitogen-activated protein kinase 1	Homo sapiens	26-29
27708396-3	2016	Here, we demonstrate that ERK/c-Jun signaling is involved in DNA demethylation of EBV immediate early (IE) gene Zta in response to 12-O-Tetradecanoylphorbol-13-acetate (TPA) stimulation.	Tetradecanoylphorbol Acetate	169-172	mitogen-activated protein kinase 1	Homo sapiens	26-29
27708396-8	2016	Thus, TPA activates ERK/c-Jun signaling, which subsequently facilitates Tet1 to bind to Zta promoter, leading to DNA demethylation, gene expression, and EBV reactivation.	Tetradecanoylphorbol Acetate	6-9	mitogen-activated protein kinase 1	Homo sapiens	20-23
27520485-7	2016	At the molecular level, the expression of several key TPA-induced pro-survival and pro-proliferative genes (Bcl2, Cyclin D1, and c-Myc) decreased rapidly after BET inhibition.	Tetradecanoylphorbol Acetate	54-57	BCL2 apoptosis regulator	Homo sapiens	108-112
27520485-11	2016	Chromatin immunoprecipitation assays showed that TPA elevated H3K27Ac enrichment in the COX2 promoter region, which is mediated by p300, and Brd4.	Tetradecanoylphorbol Acetate	49-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-92
27520485-11	2016	Chromatin immunoprecipitation assays showed that TPA elevated H3K27Ac enrichment in the COX2 promoter region, which is mediated by p300, and Brd4.	Tetradecanoylphorbol Acetate	49-52	bromodomain containing 4	Homo sapiens	141-145
27577680-5	2016	PMA, a strong activator of PKC, induces A3B at both mRNA and protein levels in cancer cell lines, and specific inhibitors of both PKC and IKK downregulate A3B expression.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	27-30
27577680-5	2016	PMA, a strong activator of PKC, induces A3B at both mRNA and protein levels in cancer cell lines, and specific inhibitors of both PKC and IKK downregulate A3B expression.	Tetradecanoylphorbol Acetate	0-3	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	Homo sapiens	40-43
27577680-5	2016	PMA, a strong activator of PKC, induces A3B at both mRNA and protein levels in cancer cell lines, and specific inhibitors of both PKC and IKK downregulate A3B expression.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	130-133
27577680-5	2016	PMA, a strong activator of PKC, induces A3B at both mRNA and protein levels in cancer cell lines, and specific inhibitors of both PKC and IKK downregulate A3B expression.	Tetradecanoylphorbol Acetate	0-3	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	Homo sapiens	155-158
27503790-6	2016	K1 inhibited both TNF- and phorbol 12-myristate 13-acetate (PMA)-induced NF-kappaB activation, as detected by transcription of synthetic (e.g. luciferase) and natural (e.g. CXCL8) genes controlled by NF-kappaB.	Tetradecanoylphorbol Acetate	27-58	nuclear factor kappa B subunit 1	Homo sapiens	73-82
27503790-6	2016	K1 inhibited both TNF- and phorbol 12-myristate 13-acetate (PMA)-induced NF-kappaB activation, as detected by transcription of synthetic (e.g. luciferase) and natural (e.g. CXCL8) genes controlled by NF-kappaB.	Tetradecanoylphorbol Acetate	27-58	C-X-C motif chemokine ligand 8	Homo sapiens	173-178
27503790-6	2016	K1 inhibited both TNF- and phorbol 12-myristate 13-acetate (PMA)-induced NF-kappaB activation, as detected by transcription of synthetic (e.g. luciferase) and natural (e.g. CXCL8) genes controlled by NF-kappaB.	Tetradecanoylphorbol Acetate	27-58	nuclear factor kappa B subunit 1	Homo sapiens	200-209
27503790-6	2016	K1 inhibited both TNF- and phorbol 12-myristate 13-acetate (PMA)-induced NF-kappaB activation, as detected by transcription of synthetic (e.g. luciferase) and natural (e.g. CXCL8) genes controlled by NF-kappaB.	Tetradecanoylphorbol Acetate	60-63	nuclear factor kappa B subunit 1	Homo sapiens	73-82
27503790-6	2016	K1 inhibited both TNF- and phorbol 12-myristate 13-acetate (PMA)-induced NF-kappaB activation, as detected by transcription of synthetic (e.g. luciferase) and natural (e.g. CXCL8) genes controlled by NF-kappaB.	Tetradecanoylphorbol Acetate	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	173-178
27503790-6	2016	K1 inhibited both TNF- and phorbol 12-myristate 13-acetate (PMA)-induced NF-kappaB activation, as detected by transcription of synthetic (e.g. luciferase) and natural (e.g. CXCL8) genes controlled by NF-kappaB.	Tetradecanoylphorbol Acetate	60-63	nuclear factor kappa B subunit 1	Homo sapiens	200-209
27746782-4	2016	Fresh peripheral blood mononuclear cells were used for measurement of ex vivo T-cell activation and of cytokine-producing CD4 T-cells following stimulation with PMA/ionomycin or HIV-1-gag-p24 antigen.	Tetradecanoylphorbol Acetate	161-164	CD4 molecule	Homo sapiens	122-125
27654969-5	2016	Specific inhibitors and mutagenesis studies showed that PKCdelta, JNK1/2, Erk1/2, NF-kappaB, and AP-1 were critical for TPA-induced uPAR expression.	Tetradecanoylphorbol Acetate	120-123	mitogen-activated protein kinase 8	Homo sapiens	66-72
27654969-5	2016	Specific inhibitors and mutagenesis studies showed that PKCdelta, JNK1/2, Erk1/2, NF-kappaB, and AP-1 were critical for TPA-induced uPAR expression.	Tetradecanoylphorbol Acetate	120-123	mitogen-activated protein kinase 3	Homo sapiens	74-80
27654969-6	2016	Application of DHA suppressed TPA-induced translocation of PKCdelta, activation of the JNK1/2 and Erk1/2 signaling pathways, and subsequent AP-1 and NF-kappaB transactivation.	Tetradecanoylphorbol Acetate	30-33	mitogen-activated protein kinase 8	Homo sapiens	87-93
27654969-6	2016	Application of DHA suppressed TPA-induced translocation of PKCdelta, activation of the JNK1/2 and Erk1/2 signaling pathways, and subsequent AP-1 and NF-kappaB transactivation.	Tetradecanoylphorbol Acetate	30-33	mitogen-activated protein kinase 3	Homo sapiens	98-104
25516146-1	2016	The aim of this study was to investigate the independent factors associated with the absence of recanalization approximately 24 h after intravenous administration of tissue-type plasminogen activator (IV TPA).	Tetradecanoylphorbol Acetate	204-207	plasminogen activator, tissue type	Homo sapiens	166-199
27240473-8	2016	For the tolerance test, THP-1 cells transfected with miRNA-128 mimic were treated with phorbol 12-myristate 13-acetate (PMA) or paraformaldehyde (PFA)-fixed Escherichia coli.	Tetradecanoylphorbol Acetate	120-123	GLI family zinc finger 2	Homo sapiens	24-29
27302770-3	2016	BC12 treatment confers a &gt;95% inhibition of IL-2 secretion in phytohaemagglutinin (PHA) plus phorbol-12-myristate-13-acetate (PMA) stimulated Jurkat T cells.	Tetradecanoylphorbol Acetate	96-127	interleukin 2	Homo sapiens	47-51
27448806-10	2016	Moreover, increased production of IL2, IFN-gamma and TNF-alpha was found in T cells of NF1 patients upon phorbol-12-myristate acetate (PMA) stimulation compared to healthy controls.	Tetradecanoylphorbol Acetate	135-138	interleukin 2	Homo sapiens	34-37
27448806-10	2016	Moreover, increased production of IL2, IFN-gamma and TNF-alpha was found in T cells of NF1 patients upon phorbol-12-myristate acetate (PMA) stimulation compared to healthy controls.	Tetradecanoylphorbol Acetate	135-138	interferon gamma	Homo sapiens	39-48
27448806-10	2016	Moreover, increased production of IL2, IFN-gamma and TNF-alpha was found in T cells of NF1 patients upon phorbol-12-myristate acetate (PMA) stimulation compared to healthy controls.	Tetradecanoylphorbol Acetate	135-138	tumor necrosis factor	Homo sapiens	53-62
27448806-10	2016	Moreover, increased production of IL2, IFN-gamma and TNF-alpha was found in T cells of NF1 patients upon phorbol-12-myristate acetate (PMA) stimulation compared to healthy controls.	Tetradecanoylphorbol Acetate	135-138	neurofibromin 1	Homo sapiens	87-90
27412623-9	2016	In E4, but not WT, mice, phorbol-12-myristate-13-acetate-treated hippocampal slices showed more dihydroxy ethidium oxidation in sham-irradiated than irradiated mice and hippocampal heme oxygenase-1 levels were higher in irradiated than sham-irradiated E4 mice.	Tetradecanoylphorbol Acetate	25-56	heme oxygenase 1	Mus musculus	181-197
27353073-8	2016	Topical compd3 penetrates the skin and suppresses phorbol myristate acetate-induced IL-13, IL-22, IL-17F, and IL-23 transcription and calcipotriol-induced thymic stromal lymphopoietin expression in mouse skin.	Tetradecanoylphorbol Acetate	50-75	interleukin 13	Mus musculus	84-89
27240473-13	2016	In THP-1 cells transfected with miRNA-128 mimic, TNF-alpha production was lower, and phosphorylation of p38 was inhibited when challenged with PMA or PFA-fixed E. coli.	Tetradecanoylphorbol Acetate	143-146	GLI family zinc finger 2	Homo sapiens	3-8
27240473-13	2016	In THP-1 cells transfected with miRNA-128 mimic, TNF-alpha production was lower, and phosphorylation of p38 was inhibited when challenged with PMA or PFA-fixed E. coli.	Tetradecanoylphorbol Acetate	143-146	mitogen-activated protein kinase 14	Homo sapiens	104-107
27266620-1	2016	BACKGROUND: The benefits of intravenous tissue-type plasminogen activator (IV-tPA) in acute ischemic stroke (AIS) are time dependent.	Tetradecanoylphorbol Acetate	78-81	plasminogen activator, tissue type	Homo sapiens	40-73
27339895-7	2016	By time-lapse FRET microscopy, IkappaBalpha ERK WWOX complex exhibits an increased binding strength by 1-2-fold after exposure to ionophore A23187/phorbol myristate acetate for 15-24 h. Meanwhile, a portion of ERK and WWOX relocates to the nucleus, suggesting their role in the induction of CD3 and CD8 expression in MOLT-4.	Tetradecanoylphorbol Acetate	147-172	mitogen-activated protein kinase 1	Homo sapiens	44-47
27531070-4	2016	In contrast to the decreased tyrosine phosphorylation, Phos-tag Western blot analysis revealed that TPA induced phosphorylation of ErbB2 in an ERK-dependent manner.	Tetradecanoylphorbol Acetate	100-103	erb-b2 receptor tyrosine kinase 2	Homo sapiens	131-136
27339895-5	2016	Upon stimulating MOLT-4 with ionophore A23187/phorbol myristate acetate, endogenous IkappaBalpha and ERK undergo rapid phosphorylation in &lt;5 min, and subsequently WWOX is Tyr-33 and Tyr-287 de-phosphorylated and Ser-14 phosphorylated.	Tetradecanoylphorbol Acetate	46-71	mitogen-activated protein kinase 1	Homo sapiens	101-104
27339895-7	2016	By time-lapse FRET microscopy, IkappaBalpha ERK WWOX complex exhibits an increased binding strength by 1-2-fold after exposure to ionophore A23187/phorbol myristate acetate for 15-24 h. Meanwhile, a portion of ERK and WWOX relocates to the nucleus, suggesting their role in the induction of CD3 and CD8 expression in MOLT-4.	Tetradecanoylphorbol Acetate	147-172	WW domain containing oxidoreductase	Homo sapiens	48-52
27339895-5	2016	Upon stimulating MOLT-4 with ionophore A23187/phorbol myristate acetate, endogenous IkappaBalpha and ERK undergo rapid phosphorylation in &lt;5 min, and subsequently WWOX is Tyr-33 and Tyr-287 de-phosphorylated and Ser-14 phosphorylated.	Tetradecanoylphorbol Acetate	46-71	WW domain containing oxidoreductase	Homo sapiens	166-170
27339895-7	2016	By time-lapse FRET microscopy, IkappaBalpha ERK WWOX complex exhibits an increased binding strength by 1-2-fold after exposure to ionophore A23187/phorbol myristate acetate for 15-24 h. Meanwhile, a portion of ERK and WWOX relocates to the nucleus, suggesting their role in the induction of CD3 and CD8 expression in MOLT-4.	Tetradecanoylphorbol Acetate	147-172	NFKB inhibitor alpha	Homo sapiens	31-43
27339895-7	2016	By time-lapse FRET microscopy, IkappaBalpha ERK WWOX complex exhibits an increased binding strength by 1-2-fold after exposure to ionophore A23187/phorbol myristate acetate for 15-24 h. Meanwhile, a portion of ERK and WWOX relocates to the nucleus, suggesting their role in the induction of CD3 and CD8 expression in MOLT-4.	Tetradecanoylphorbol Acetate	147-172	mitogen-activated protein kinase 1	Homo sapiens	210-213
27339895-7	2016	By time-lapse FRET microscopy, IkappaBalpha ERK WWOX complex exhibits an increased binding strength by 1-2-fold after exposure to ionophore A23187/phorbol myristate acetate for 15-24 h. Meanwhile, a portion of ERK and WWOX relocates to the nucleus, suggesting their role in the induction of CD3 and CD8 expression in MOLT-4.	Tetradecanoylphorbol Acetate	147-172	WW domain containing oxidoreductase	Homo sapiens	218-222
27409664-6	2016	Furthermore, downregulation of CTBP1 by miR-644a upregulates wild type- or mutant-p53 which acts as a "molecular switch" between G1-arrest and apoptosis by inducing cyclin-dependent kinase inhibitor 1 (p21, CDKN1A, CIP1) or pro-apoptotic phorbol-12-myristate-13-acetate-induced protein 1 (Noxa, PMAIP1), respectively.	Tetradecanoylphorbol Acetate	238-269	tumor protein p53	Homo sapiens	82-85
27467817-5	2016	METHODS AND RESULTS: Phorbol myristate acetate (PMA) differentiated THP-1 macrophages were stimulated with oxidized low density lipoprotein and subsequent analysis of this conditioned media (oxLDL CM) revealed a strong release of TNF-alpha.	Tetradecanoylphorbol Acetate	21-46	GLI family zinc finger 2	Homo sapiens	68-73
27307289-0	2016	Phorbol-12-myristate-13-acetate induces nociceptin in human Mono Mac 6 cells via multiple transduction signalling pathways.	Tetradecanoylphorbol Acetate	0-31	prepronociceptin	Homo sapiens	40-50
27307103-8	2016	However, the phorbol 12-myristate 13-acetate (PMA)-induced differentiation of U937 and THP-1 cell lines induces a significant tumor necrosis factor-alpha production in resting macrophages.	Tetradecanoylphorbol Acetate	13-44	GLI family zinc finger 2	Homo sapiens	87-92
27307103-8	2016	However, the phorbol 12-myristate 13-acetate (PMA)-induced differentiation of U937 and THP-1 cell lines induces a significant tumor necrosis factor-alpha production in resting macrophages.	Tetradecanoylphorbol Acetate	13-44	tumor necrosis factor	Homo sapiens	126-153
27307103-8	2016	However, the phorbol 12-myristate 13-acetate (PMA)-induced differentiation of U937 and THP-1 cell lines induces a significant tumor necrosis factor-alpha production in resting macrophages.	Tetradecanoylphorbol Acetate	46-49	GLI family zinc finger 2	Homo sapiens	87-92
27307103-8	2016	However, the phorbol 12-myristate 13-acetate (PMA)-induced differentiation of U937 and THP-1 cell lines induces a significant tumor necrosis factor-alpha production in resting macrophages.	Tetradecanoylphorbol Acetate	46-49	tumor necrosis factor	Homo sapiens	126-153
27467817-5	2016	METHODS AND RESULTS: Phorbol myristate acetate (PMA) differentiated THP-1 macrophages were stimulated with oxidized low density lipoprotein and subsequent analysis of this conditioned media (oxLDL CM) revealed a strong release of TNF-alpha.	Tetradecanoylphorbol Acetate	21-46	tumor necrosis factor	Homo sapiens	230-239
27467817-5	2016	METHODS AND RESULTS: Phorbol myristate acetate (PMA) differentiated THP-1 macrophages were stimulated with oxidized low density lipoprotein and subsequent analysis of this conditioned media (oxLDL CM) revealed a strong release of TNF-alpha.	Tetradecanoylphorbol Acetate	48-51	GLI family zinc finger 2	Homo sapiens	68-73
27467817-5	2016	METHODS AND RESULTS: Phorbol myristate acetate (PMA) differentiated THP-1 macrophages were stimulated with oxidized low density lipoprotein and subsequent analysis of this conditioned media (oxLDL CM) revealed a strong release of TNF-alpha.	Tetradecanoylphorbol Acetate	48-51	tumor necrosis factor	Homo sapiens	230-239
27452759-3	2016	Phorbol 12-myristate 13-acetate(PMA) and macrophage colony stimulating factor (M-CSF) were used to make THP-1 monocytes differentiate into TAMs.	Tetradecanoylphorbol Acetate	0-31	GLI family zinc finger 2	Homo sapiens	104-109
27374082-6	2016	Indeed, knockdown (kd) of Cdh1 in HL-60 cell line (AML with maturation, FAB M2) led to less differentiated cells and a delay in PMA-induced differentiation.	Tetradecanoylphorbol Acetate	128-131	cadherin 1	Homo sapiens	26-30
27170516-6	2016	Furthermore, sacran significantly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema and mRNA expression levels of cyclooxygenase (COX)-2 as well as pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.	Tetradecanoylphorbol Acetate	45-81	interleukin 1 beta	Mus musculus	246-268
27170516-6	2016	Furthermore, sacran significantly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema and mRNA expression levels of cyclooxygenase (COX)-2 as well as pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.	Tetradecanoylphorbol Acetate	45-81	interleukin 6	Mus musculus	274-278
27170516-6	2016	Furthermore, sacran significantly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema and mRNA expression levels of cyclooxygenase (COX)-2 as well as pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.	Tetradecanoylphorbol Acetate	83-86	tumor necrosis factor	Mus musculus	211-244
27170516-6	2016	Furthermore, sacran significantly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema and mRNA expression levels of cyclooxygenase (COX)-2 as well as pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.	Tetradecanoylphorbol Acetate	83-86	interleukin 1 beta	Mus musculus	246-268
27170516-6	2016	Furthermore, sacran significantly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema and mRNA expression levels of cyclooxygenase (COX)-2 as well as pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.	Tetradecanoylphorbol Acetate	83-86	interleukin 6	Mus musculus	274-278
27348727-7	2016	Furthermore, AE-COS at 20mug/ml reduced the expression level of p50, a part of NF-kappaB, compared with phorbol-12- myristate-13- acetate (PMA) group.	Tetradecanoylphorbol Acetate	104-137	nuclear factor kappa B subunit 1	Homo sapiens	64-67
27365551-3	2016	METHODS: THP-1 cells (a human monocytic cell line) were cultured and differentiated to macrophages by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	102-133	GLI family zinc finger 2	Homo sapiens	9-14
27331630-4	2016	Topical administration of AC also reduced the expression of pro-inflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 in TPA-stimulated mouse ears.	Tetradecanoylphorbol Acetate	128-131	interleukin 6	Mus musculus	120-124
27176480-3	2016	In this study, phorbol myristate acetate (PMA) was used to induce the differentiation of THP-1 monocytes to macrophages.	Tetradecanoylphorbol Acetate	15-40	GLI family zinc finger 2	Homo sapiens	89-94
27176480-3	2016	In this study, phorbol myristate acetate (PMA) was used to induce the differentiation of THP-1 monocytes to macrophages.	Tetradecanoylphorbol Acetate	42-45	GLI family zinc finger 2	Homo sapiens	89-94
26970286-9	2016	In addition, intra-articular injection of the PKC activator phorbol 12-myristate 13-acetate increased capsaicin-induced pain-related behavior in normal rats.	Tetradecanoylphorbol Acetate	60-91	protein kinase C, epsilon	Rattus norvegicus	46-49
27128549-7	2016	PCSK9 levels were also linearly associated with TPA after multivariate adjustment including LDL-C (P=0.008).	Tetradecanoylphorbol Acetate	48-51	component of oligomeric golgi complex 2	Homo sapiens	92-97
27128549-8	2016	Among participants with the lowest or second tertile of LDL-C, PCSK9 quartiles were linearly associated with TPA (P=0.021), but the association lost significance after additional adjustment for very low-density lipoprotein cholesterol (VLDL-C) tertiles (P=0.072).	Tetradecanoylphorbol Acetate	109-112	component of oligomeric golgi complex 2	Homo sapiens	56-61
27401543-0	2016	Effect of 12-O-tetradecanoylphorbol-13-acetate-induced psoriasis-like skin lesions on systemic inflammation and atherosclerosis in hypercholesterolaemic apolipoprotein E deficient mice.	Tetradecanoylphorbol Acetate	10-46	apolipoprotein E	Mus musculus	153-169
27401543-7	2016	CONCLUSIONS: TPA-induced psoriasis-like skin inflammation in atherosclerosis-prone ApoE(-/-) mice evoked systemic immune-inflammatory effects, but did not affect atherogenesis.	Tetradecanoylphorbol Acetate	13-16	apolipoprotein E	Mus musculus	83-87
27179129-7	2016	On the contrary, thrombin dose-dependently prolonged the tPA-PCLT, which was mostly abolished by inhibitors of carboxypeptidase and activated FXIII, suggesting that the prolongation is TAFI- and Factor XIII-dependent.	Tetradecanoylphorbol Acetate	57-60	coagulation factor II, thrombin	Homo sapiens	17-25
27175590-4	2016	In this study, H68 fibroblasts, THP-1 and phorbol-12-myristate-13-acetate (PMA)-treated THP-1 (PMA-THP-1) cells were incubated with conditioned media of control (control-CM) and 14-3-3sigma-overepxressing cells (14-3-3sigma-CM), followed by co-culture with HCC cells.	Tetradecanoylphorbol Acetate	42-73	GLI family zinc finger 2	Homo sapiens	88-93
27327083-5	2016	We also found a significant response of TBX15 to TNF-alpha activation of the NF-kappaB pathway using five cancer cell lines, and similar results were obtained when NF-kappaB was activated with PMA/ionomycin.	Tetradecanoylphorbol Acetate	193-196	nuclear factor kappa B subunit 1	Homo sapiens	164-173
27175590-4	2016	In this study, H68 fibroblasts, THP-1 and phorbol-12-myristate-13-acetate (PMA)-treated THP-1 (PMA-THP-1) cells were incubated with conditioned media of control (control-CM) and 14-3-3sigma-overepxressing cells (14-3-3sigma-CM), followed by co-culture with HCC cells.	Tetradecanoylphorbol Acetate	75-78	GLI family zinc finger 2	Homo sapiens	88-93
27175590-4	2016	In this study, H68 fibroblasts, THP-1 and phorbol-12-myristate-13-acetate (PMA)-treated THP-1 (PMA-THP-1) cells were incubated with conditioned media of control (control-CM) and 14-3-3sigma-overepxressing cells (14-3-3sigma-CM), followed by co-culture with HCC cells.	Tetradecanoylphorbol Acetate	75-78	GLI family zinc finger 2	Homo sapiens	95-104
27175590-4	2016	In this study, H68 fibroblasts, THP-1 and phorbol-12-myristate-13-acetate (PMA)-treated THP-1 (PMA-THP-1) cells were incubated with conditioned media of control (control-CM) and 14-3-3sigma-overepxressing cells (14-3-3sigma-CM), followed by co-culture with HCC cells.	Tetradecanoylphorbol Acetate	42-73	GLI family zinc finger 2	Homo sapiens	95-104
27039668-10	2016	EBV+ T/NK-cell line cells treated with phorbol 12-myristate 13-acetate produced BZLF1 and BDRF1 mRNA, and encapsidated EBV DNA was detected in the culture supernatants of cell line cells.	Tetradecanoylphorbol Acetate	39-70	capsid scaffold protein	Human gammaherpesvirus 4	90-95
27022018-3	2016	Ectodomain shedding of both human and mouse RAGE was dependent on ADAM10 activity and induced with chemical activators of shedding (ionomycin, phorbol 12-myristate 13-acetate, and 4-aminophenylmercuric acetate) and endogenous stimuli (serum and RAGE ligands).	Tetradecanoylphorbol Acetate	143-174	advanced glycosylation end product-specific receptor	Mus musculus	44-48
26912410-6	2016	PAK2-inhibition reversed the dual stimulatory/inhibitory effect of CCK/TPA on the PI3K/Akt/GSK-3beta pathway.	Tetradecanoylphorbol Acetate	71-74	AKT serine/threonine kinase 1	Rattus norvegicus	87-90
27075590-7	2016	17-AAG inhibited PMA-induced cyclooxygenase-2 (COX-2) mRNA expression and protein level.	Tetradecanoylphorbol Acetate	17-20	prostaglandin-endoperoxide synthase 2	Homo sapiens	29-45
27075590-7	2016	17-AAG inhibited PMA-induced cyclooxygenase-2 (COX-2) mRNA expression and protein level.	Tetradecanoylphorbol Acetate	17-20	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52
27032751-3	2016	Phorbol 12-myristate 13-acetate (PMA), which is a common protein kinase C (PKC) activator, was shown to promote the post-translational processing and nuclear translocation of SREBP-2 in hepatic cells in the current study.	Tetradecanoylphorbol Acetate	0-31	sterol regulatory element binding transcription factor 2	Homo sapiens	175-182
27032751-3	2016	Phorbol 12-myristate 13-acetate (PMA), which is a common protein kinase C (PKC) activator, was shown to promote the post-translational processing and nuclear translocation of SREBP-2 in hepatic cells in the current study.	Tetradecanoylphorbol Acetate	33-36	sterol regulatory element binding transcription factor 2	Homo sapiens	175-182
27035791-6	2016	Rev-AuNPs suppressed TPA-induced enzymatic activity and the expression of matrix metalloproteinase (MMP)-9 and cyclooxygenase-2 (COX-2).	Tetradecanoylphorbol Acetate	21-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	111-127
26567910-3	2016	We assessed mediation by tHcy of the association of estimated glomerular filtration rate (eGFR CKD/EPI) with carotid total plaque area (TPA) and carotid stenosis.	Tetradecanoylphorbol Acetate	136-139	epidermal growth factor receptor	Homo sapiens	90-94
26567910-8	2016	After adjustment [age, sex, SBP, smoking (in pack years), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and weight], eGFR and tHcy were independently associated with TPA (P &lt; 0.01), but when both were added to the model, their significance was attenuated (P = 0.06 for eGFR, 0.03 for tHcy).	Tetradecanoylphorbol Acetate	182-185	epidermal growth factor receptor	Homo sapiens	133-137
26567910-9	2016	Mediation analysis showed that tHcy seems to contribute to a significant mediation of the association of eGFR with TPA but not stenosis; after adjustment for the set of risk factors listed above, tHcy still demonstrated significant mediation on TPA (P = 0.03), but not on stenosis (P = 0.16).	Tetradecanoylphorbol Acetate	115-118	epidermal growth factor receptor	Homo sapiens	105-109
26567910-9	2016	Mediation analysis showed that tHcy seems to contribute to a significant mediation of the association of eGFR with TPA but not stenosis; after adjustment for the set of risk factors listed above, tHcy still demonstrated significant mediation on TPA (P = 0.03), but not on stenosis (P = 0.16).	Tetradecanoylphorbol Acetate	245-248	epidermal growth factor receptor	Homo sapiens	105-109
27376806-4	2016	Phorbol12-myristate13-acetate (PMA) was used to induce human acute mononuclear leukemia cells THP-1 to differentiate into macrophages.	Tetradecanoylphorbol Acetate	0-29	GLI family zinc finger 2	Homo sapiens	94-99
27376806-4	2016	Phorbol12-myristate13-acetate (PMA) was used to induce human acute mononuclear leukemia cells THP-1 to differentiate into macrophages.	Tetradecanoylphorbol Acetate	31-34	GLI family zinc finger 2	Homo sapiens	94-99
27035791-12	2016	Our findings revealed that the anti-invasive effects of Rev-AuNPs in response to TPA-stimulation were mediated by the suppression of MMP-9, COX-2, NF-kappaB, AP-1, PI3K/Akt and ERK and/or the activation of HO-1 signaling cascades.	Tetradecanoylphorbol Acetate	81-84	prostaglandin-endoperoxide synthase 2	Homo sapiens	140-145
27035791-12	2016	Our findings revealed that the anti-invasive effects of Rev-AuNPs in response to TPA-stimulation were mediated by the suppression of MMP-9, COX-2, NF-kappaB, AP-1, PI3K/Akt and ERK and/or the activation of HO-1 signaling cascades.	Tetradecanoylphorbol Acetate	81-84	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	158-162
27035791-12	2016	Our findings revealed that the anti-invasive effects of Rev-AuNPs in response to TPA-stimulation were mediated by the suppression of MMP-9, COX-2, NF-kappaB, AP-1, PI3K/Akt and ERK and/or the activation of HO-1 signaling cascades.	Tetradecanoylphorbol Acetate	81-84	AKT serine/threonine kinase 1	Homo sapiens	169-172
27035791-12	2016	Our findings revealed that the anti-invasive effects of Rev-AuNPs in response to TPA-stimulation were mediated by the suppression of MMP-9, COX-2, NF-kappaB, AP-1, PI3K/Akt and ERK and/or the activation of HO-1 signaling cascades.	Tetradecanoylphorbol Acetate	81-84	mitogen-activated protein kinase 1	Homo sapiens	177-180
27035791-6	2016	Rev-AuNPs suppressed TPA-induced enzymatic activity and the expression of matrix metalloproteinase (MMP)-9 and cyclooxygenase-2 (COX-2).	Tetradecanoylphorbol Acetate	21-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	129-134
27035791-7	2016	Furthermore, Rev-AuNP treatment remarkably downregulated TPA-induced nuclear translocation and transcriptional activation of nuclear transcription factor-kappaB (NF-kappaB) and activator protein-1 (AP-1).	Tetradecanoylphorbol Acetate	57-60	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	177-196
27035791-7	2016	Furthermore, Rev-AuNP treatment remarkably downregulated TPA-induced nuclear translocation and transcriptional activation of nuclear transcription factor-kappaB (NF-kappaB) and activator protein-1 (AP-1).	Tetradecanoylphorbol Acetate	57-60	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	198-202
27105502-8	2016	The in vitro study showed that MALT1 inhibitors decreased production of IL-1beta/IL-18 in phorbol myristate acetate-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	90-115	interleukin 1 beta	Homo sapiens	72-80
27105502-8	2016	The in vitro study showed that MALT1 inhibitors decreased production of IL-1beta/IL-18 in phorbol myristate acetate-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	90-115	nuclear factor kappa B subunit 1	Homo sapiens	212-221
27105502-8	2016	The in vitro study showed that MALT1 inhibitors decreased production of IL-1beta/IL-18 in phorbol myristate acetate-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	90-115	NLR family pyrin domain containing 3	Homo sapiens	226-231
26988984-10	2016	Moreover, reserpine induced Nrf2 expression via an epigenetic pathway in skin epidermal JB6 P+ cells, enhancing the protective antioxidant activity and decreasing TPA-induced cell transformation.	Tetradecanoylphorbol Acetate	163-166	NFE2 like bZIP transcription factor 2	Homo sapiens	28-32
27087645-5	2016	Oleamide was identified as an active compound of ALE, which attenuated the secretion of histamine and the production of tumor necrosis factor (TNF)-alpha and interleukin-4 (IL-4) in cells treated with compound 48/80 or A23187/phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	226-251	tumor necrosis factor	Rattus norvegicus	120-153
27036017-3	2016	TPA dose- and time-dependently increased PKCdelta and STAT3alpha activation and GSK3beta phosphorylation; up-regulated Wnt-1, beta-catenin, and STAT3alpha expression; and increased the nuclear translocation of beta-catenin and STAT3alpha.	Tetradecanoylphorbol Acetate	0-3	Wnt family member 1	Homo sapiens	119-124
27036017-5	2016	WP1066, a STAT3 inhibitor, suppressed TPA-induced STAT3alpha DNA binding activity and beta-catenin expression.	Tetradecanoylphorbol Acetate	38-41	signal transducer and activator of transcription 3	Homo sapiens	10-15
27036017-5	2016	WP1066, a STAT3 inhibitor, suppressed TPA-induced STAT3alpha DNA binding activity and beta-catenin expression.	Tetradecanoylphorbol Acetate	38-41	signal transducer and activator of transcription 3	Homo sapiens	50-55
27036017-8	2016	TPA also induced Wnt-1 expression and secretion, and blocking Wnt-1 signaling abrogated beta-catenin induction.	Tetradecanoylphorbol Acetate	0-3	Wnt family member 1	Homo sapiens	17-22
27036017-9	2016	DHA pretreatment attenuated TPA-induced cell migration, PKCdelta and STAT3alpha activation, GSK3beta phosphorylation, and Wnt-1, beta-catenin, STAT3alpha, and fascin-1 expression.	Tetradecanoylphorbol Acetate	28-31	Wnt family member 1	Homo sapiens	122-127
27036017-10	2016	Our results demonstrated that TPA-induced migration is likely associated with the PKCdelta and Wnt-1 pathways, which lead to STAT3alpha activation, GSK3beta inactivation, and beta-catenin increase and up-regulation of fascin-1 expression.	Tetradecanoylphorbol Acetate	30-33	Wnt family member 1	Homo sapiens	95-100
27036017-11	2016	Moreover, the anti-metastatic potential of DHA is partly attributed to its suppression of TPA-activated PKCdelta and Wnt-1 signaling.	Tetradecanoylphorbol Acetate	90-93	Wnt family member 1	Homo sapiens	117-122
26991968-5	2016	Tetrameric tape ADDA displays five reversible waves in a narrow range of 1.13 V. Two-photon absorption (TPA) measurement confirmed that the pi-conjugation path is extended from 12 to ADDA and the molecular polarizability of ADA is larger than that of AAA.	Tetradecanoylphorbol Acetate	104-107	adducin 1	Homo sapiens	16-20
26991968-5	2016	Tetrameric tape ADDA displays five reversible waves in a narrow range of 1.13 V. Two-photon absorption (TPA) measurement confirmed that the pi-conjugation path is extended from 12 to ADDA and the molecular polarizability of ADA is larger than that of AAA.	Tetradecanoylphorbol Acetate	104-107	adducin 1	Homo sapiens	183-187
27119568-3	2016	In this study, we demonstrated that exposure of anti-CD3/CD28 or phorbol 12-myristate 13-acetate (PMA)/ionomycin-activated HuT-78 T lymphocyte cells to 10-20 mM d-lactate significantly increased IL-4 and IL-13 production.	Tetradecanoylphorbol Acetate	65-96	interleukin 4	Homo sapiens	195-199
26950613-8	2016	Furthermore, TGN reduced iNOS and COX-2 expression in a 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation mouse model.	Tetradecanoylphorbol Acetate	56-92	nitric oxide synthase 2, inducible	Mus musculus	25-29
26950613-8	2016	Furthermore, TGN reduced iNOS and COX-2 expression in a 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation mouse model.	Tetradecanoylphorbol Acetate	94-97	nitric oxide synthase 2, inducible	Mus musculus	25-29
26950613-0	2016	Heme oxygenase-1-mediated anti-inflammatory effects of tussilagonone on macrophages and 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation in mice.	Tetradecanoylphorbol Acetate	88-124	heme oxygenase 1	Mus musculus	0-16
26945908-12	2016	17beta-estradiol inhibits IL8-up-regulated Src downstream target proteins including p-Cas, p-paxillin, p-ERK1/2, p-JNK1/2, MMP9, tPA and uPA.	Tetradecanoylphorbol Acetate	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
26945908-12	2016	17beta-estradiol inhibits IL8-up-regulated Src downstream target proteins including p-Cas, p-paxillin, p-ERK1/2, p-JNK1/2, MMP9, tPA and uPA.	Tetradecanoylphorbol Acetate	129-132	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-46
27257341-5	2016	CAPE also suppressed the activation of TPA-elicited nuclear factor-kappaB (NF-kappaB) and accumulation of NADPH oxidase 2 (NOX2)-derived reactive oxygen species (ROS), but did not affect extracellular signal-regulated kinase (ERK) phosphorylation.	Tetradecanoylphorbol Acetate	39-42	mitogen-activated protein kinase 1	Homo sapiens	187-224
27257341-5	2016	CAPE also suppressed the activation of TPA-elicited nuclear factor-kappaB (NF-kappaB) and accumulation of NADPH oxidase 2 (NOX2)-derived reactive oxygen species (ROS), but did not affect extracellular signal-regulated kinase (ERK) phosphorylation.	Tetradecanoylphorbol Acetate	39-42	mitogen-activated protein kinase 1	Homo sapiens	226-229
27119568-3	2016	In this study, we demonstrated that exposure of anti-CD3/CD28 or phorbol 12-myristate 13-acetate (PMA)/ionomycin-activated HuT-78 T lymphocyte cells to 10-20 mM d-lactate significantly increased IL-4 and IL-13 production.	Tetradecanoylphorbol Acetate	65-96	interleukin 13	Homo sapiens	204-209
27119568-3	2016	In this study, we demonstrated that exposure of anti-CD3/CD28 or phorbol 12-myristate 13-acetate (PMA)/ionomycin-activated HuT-78 T lymphocyte cells to 10-20 mM d-lactate significantly increased IL-4 and IL-13 production.	Tetradecanoylphorbol Acetate	98-101	interleukin 4	Homo sapiens	195-199
27119568-3	2016	In this study, we demonstrated that exposure of anti-CD3/CD28 or phorbol 12-myristate 13-acetate (PMA)/ionomycin-activated HuT-78 T lymphocyte cells to 10-20 mM d-lactate significantly increased IL-4 and IL-13 production.	Tetradecanoylphorbol Acetate	98-101	interleukin 13	Homo sapiens	204-209
27123161-6	2016	In addition, Apo-9"-fucoxanthinone inhibited the expression of interleukin-4, interferon-gamma and tumor necrosis factor-alpha by phorbol 12-myristate 13-acetate and ionomycin-stimulated lymphocytes.	Tetradecanoylphorbol Acetate	130-161	interferon gamma	Mus musculus	78-126
25753147-2	2016	We have reported that mice with germline loss of p38delta exhibited a reduced susceptibility to skin tumor development compared with wild-type mice in the two-stage 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) chemical skin carcinogenesis model.	Tetradecanoylphorbol Acetate	203-239	mitogen-activated protein kinase 13	Homo sapiens	49-57
25753147-2	2016	We have reported that mice with germline loss of p38delta exhibited a reduced susceptibility to skin tumor development compared with wild-type mice in the two-stage 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) chemical skin carcinogenesis model.	Tetradecanoylphorbol Acetate	241-244	mitogen-activated protein kinase 13	Homo sapiens	49-57
25753147-5	2016	Notably, a short-term DMBA/TPA challenge, modeling the initial stages of chemical skin carcinogenesis treatment, elicited an enhanced inflammation in p38delta-null skin compared with skin of wild-type mice, as assessed by measuring the expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-17, and TNFalpha.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 13	Homo sapiens	150-158
25753147-5	2016	Notably, a short-term DMBA/TPA challenge, modeling the initial stages of chemical skin carcinogenesis treatment, elicited an enhanced inflammation in p38delta-null skin compared with skin of wild-type mice, as assessed by measuring the expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-17, and TNFalpha.	Tetradecanoylphorbol Acetate	27-30	interleukin 1 beta	Mus musculus	288-296
25753147-5	2016	Notably, a short-term DMBA/TPA challenge, modeling the initial stages of chemical skin carcinogenesis treatment, elicited an enhanced inflammation in p38delta-null skin compared with skin of wild-type mice, as assessed by measuring the expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-17, and TNFalpha.	Tetradecanoylphorbol Acetate	27-30	interleukin 6	Mus musculus	298-302
25753147-5	2016	Notably, a short-term DMBA/TPA challenge, modeling the initial stages of chemical skin carcinogenesis treatment, elicited an enhanced inflammation in p38delta-null skin compared with skin of wild-type mice, as assessed by measuring the expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-17, and TNFalpha.	Tetradecanoylphorbol Acetate	27-30	tumor necrosis factor	Mus musculus	315-323
25753147-6	2016	Additionally, p38delta-null skin and p38delta-null keratinocytes exhibited increased p38alpha activation and signaling in response to acute inflammatory challenges, suggesting a role for p38alpha in stimulating the elevated inflammatory response in p38delta-null skin during the initial phases of the DMBA/TPA treatment compared with similarly treated p38delta(+/+) skin.	Tetradecanoylphorbol Acetate	306-309	mitogen-activated protein kinase 13	Homo sapiens	14-22
25753147-6	2016	Additionally, p38delta-null skin and p38delta-null keratinocytes exhibited increased p38alpha activation and signaling in response to acute inflammatory challenges, suggesting a role for p38alpha in stimulating the elevated inflammatory response in p38delta-null skin during the initial phases of the DMBA/TPA treatment compared with similarly treated p38delta(+/+) skin.	Tetradecanoylphorbol Acetate	306-309	mitogen-activated protein kinase 13	Homo sapiens	37-45
25753147-6	2016	Additionally, p38delta-null skin and p38delta-null keratinocytes exhibited increased p38alpha activation and signaling in response to acute inflammatory challenges, suggesting a role for p38alpha in stimulating the elevated inflammatory response in p38delta-null skin during the initial phases of the DMBA/TPA treatment compared with similarly treated p38delta(+/+) skin.	Tetradecanoylphorbol Acetate	306-309	mitogen-activated protein kinase 13	Homo sapiens	37-45
25753147-6	2016	Additionally, p38delta-null skin and p38delta-null keratinocytes exhibited increased p38alpha activation and signaling in response to acute inflammatory challenges, suggesting a role for p38alpha in stimulating the elevated inflammatory response in p38delta-null skin during the initial phases of the DMBA/TPA treatment compared with similarly treated p38delta(+/+) skin.	Tetradecanoylphorbol Acetate	306-309	mitogen-activated protein kinase 13	Homo sapiens	37-45
25787879-0	2016	Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase kinase 4	Homo sapiens	92-96
25787879-5	2016	DGC treatment attenuated TPA-induced activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) transcriptional activation, two major regulators of TPA-induced cell transformation, and COX-2 expression.	Tetradecanoylphorbol Acetate	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
25787879-6	2016	TPA-induced phosphorylation of p38, JNK1/2 and Akt was also suppressed by DGC.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	31-34
25787879-6	2016	TPA-induced phosphorylation of p38, JNK1/2 and Akt was also suppressed by DGC.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	36-42
25787879-6	2016	TPA-induced phosphorylation of p38, JNK1/2 and Akt was also suppressed by DGC.	Tetradecanoylphorbol Acetate	0-3	AKT serine/threonine kinase 1	Homo sapiens	47-50
27082871-9	2016	After stimulation with phorbol-12-myristate 13-acetate and ionomycin, the proportion of T cells producing interferon-gamma or interleukin-2 was higher in the low-IC-TAC group than in the high-IC-TAC group.	Tetradecanoylphorbol Acetate	23-54	interferon gamma	Homo sapiens	106-122
27082871-9	2016	After stimulation with phorbol-12-myristate 13-acetate and ionomycin, the proportion of T cells producing interferon-gamma or interleukin-2 was higher in the low-IC-TAC group than in the high-IC-TAC group.	Tetradecanoylphorbol Acetate	23-54	interleukin 2	Homo sapiens	126-139
26852212-5	2016	Additionally, the effect of GMHGYGT on the phorbol-12-myristate-13-acetate plus calcium ionophore A23187-induced phosphorylation of extracellular signal-regulated kinase, C-Jun N-terminal kinase and p38 in HMC-1 cells was investigated.	Tetradecanoylphorbol Acetate	43-74	mitogen-activated protein kinase 14	Homo sapiens	199-202
27104574-3	2016	Their ability to induce the production of cytokines TNFalpha, IL-1beta and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed.	Tetradecanoylphorbol Acetate	83-114	tumor necrosis factor	Homo sapiens	52-60
27104574-3	2016	Their ability to induce the production of cytokines TNFalpha, IL-1beta and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed.	Tetradecanoylphorbol Acetate	83-114	interleukin 6	Homo sapiens	75-79
27104574-3	2016	Their ability to induce the production of cytokines TNFalpha, IL-1beta and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed.	Tetradecanoylphorbol Acetate	116-119	tumor necrosis factor	Homo sapiens	52-60
27104574-3	2016	Their ability to induce the production of cytokines TNFalpha, IL-1beta and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed.	Tetradecanoylphorbol Acetate	116-119	interleukin 1 beta	Homo sapiens	62-70
27104574-3	2016	Their ability to induce the production of cytokines TNFalpha, IL-1beta and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed.	Tetradecanoylphorbol Acetate	116-119	interleukin 6	Homo sapiens	75-79
26867495-5	2016	MPO or activated human neutrophils (by phorbol myristate acetate) catalyzed the oxidation of INH and formed several free radical intermediates; the inclusion of superoxide dismutase revealed a carbon-centered radical which is considered to be the reactive metabolite that binds with NAD(+).	Tetradecanoylphorbol Acetate	39-64	myeloperoxidase	Homo sapiens	0-3
27033421-5	2016	Human neutrophils were stimulated with H2O2 or phorbol 12-myristate 13-acetate (PMA) for MPO activation and subsequently treated with calcium ionophore A23187 inducing 5-LOX product formation on endogenous AA.	Tetradecanoylphorbol Acetate	47-78	myeloperoxidase	Homo sapiens	89-92
27033421-5	2016	Human neutrophils were stimulated with H2O2 or phorbol 12-myristate 13-acetate (PMA) for MPO activation and subsequently treated with calcium ionophore A23187 inducing 5-LOX product formation on endogenous AA.	Tetradecanoylphorbol Acetate	80-83	myeloperoxidase	Homo sapiens	89-92
27033421-10	2016	In contrast, the pre-stimulation with PMA resulted in different changes of 5-LOX product formation leading to a reduced amount of 5-HETE unaffected by MPO inhibition.	Tetradecanoylphorbol Acetate	38-41	arachidonate 5-lipoxygenase	Homo sapiens	75-80
27033421-10	2016	In contrast, the pre-stimulation with PMA resulted in different changes of 5-LOX product formation leading to a reduced amount of 5-HETE unaffected by MPO inhibition.	Tetradecanoylphorbol Acetate	38-41	myeloperoxidase	Homo sapiens	151-154
26786102-5	2016	We show that androgen signaling suppresses TPA-induced c-Fos expression through repressing a PKC/MEK/ERK/ELK-1 signaling pathway.	Tetradecanoylphorbol Acetate	43-46	mitogen-activated protein kinase kinase 7	Homo sapiens	97-100
27043542-6	2016	Subsequent mechanistic studies revealed that C2 ceramide inhibits PMA-induced mitogen-activated protein kinase (MAPK) phosphorylation and nuclear factor (NF)-kappaB/activator protein (AP)-1 DNA binding activities.	Tetradecanoylphorbol Acetate	66-69	neurofibromin 1	Homo sapiens	154-189
27043542-7	2016	Furthermore, C2 ceramide significantly inhibited PMA-induced reactive oxygen species (ROS) production and NADPH oxidase 4 (NOX4) expression, and inhibition of ROS by diphenylene iodonium (DPI, NADPH oxidase inhibitor) mimicked the effects of C2 ceramide on MMP expression and NF-kappaB/AP-1 via inhibition of p38 MAPK.	Tetradecanoylphorbol Acetate	49-52	mitogen-activated protein kinase 14	Homo sapiens	309-312
26769967-2	2016	However, studies with pharmacological agonists (e.g. phorbol 12-myristate 13-acetate (PMA)) indicate that prolonged stimulation leads to PKCalpha desensitization via dephosphorylation and/or degradation.	Tetradecanoylphorbol Acetate	53-84	protein kinase C alpha	Homo sapiens	137-145
26769967-2	2016	However, studies with pharmacological agonists (e.g. phorbol 12-myristate 13-acetate (PMA)) indicate that prolonged stimulation leads to PKCalpha desensitization via dephosphorylation and/or degradation.	Tetradecanoylphorbol Acetate	86-89	protein kinase C alpha	Homo sapiens	137-145
26786102-5	2016	We show that androgen signaling suppresses TPA-induced c-Fos expression through repressing a PKC/MEK/ERK/ELK-1 signaling pathway.	Tetradecanoylphorbol Acetate	43-46	mitogen-activated protein kinase 1	Homo sapiens	101-104
26786102-10	2016	Acquisition of androgen-independent killing by TPA correlates with activation of p38(MAPK), suppression of ERK1/2, and loss of c-Fos.	Tetradecanoylphorbol Acetate	47-50	mitogen-activated protein kinase 1	Homo sapiens	81-84
26786102-10	2016	Acquisition of androgen-independent killing by TPA correlates with activation of p38(MAPK), suppression of ERK1/2, and loss of c-Fos.	Tetradecanoylphorbol Acetate	47-50	mitogen-activated protein kinase 3	Homo sapiens	107-113
26739385-4	2016	Compound 8 exhibited inhibition of the secretion of IL-2 in phytohemagglutinin (PHA) and phorbol myristate acetate (PMA) stimulated Jurkat cells, and the IC50 value was 17.2 muM.	Tetradecanoylphorbol Acetate	89-114	interleukin 2	Homo sapiens	52-56
26940200-4	2016	In this study, we demonstrate that mTOR inhibitors-rapamycin (RAP), temisirolimus (TEM), torin-1 (TOR) and PP242 suppress invasion and migration induced by Tumor Necrosis Factor-alpha (TNFalpha) and tumor promoter, Phorbol 12-myristate 13-acetate (PMA) and also reduce the expression of the TNFalpha and IL1beta suggesting their potential to regulate factors in microenvironment that support tumor progression.	Tetradecanoylphorbol Acetate	215-246	mechanistic target of rapamycin kinase	Homo sapiens	35-39
26940200-4	2016	In this study, we demonstrate that mTOR inhibitors-rapamycin (RAP), temisirolimus (TEM), torin-1 (TOR) and PP242 suppress invasion and migration induced by Tumor Necrosis Factor-alpha (TNFalpha) and tumor promoter, Phorbol 12-myristate 13-acetate (PMA) and also reduce the expression of the TNFalpha and IL1beta suggesting their potential to regulate factors in microenvironment that support tumor progression.	Tetradecanoylphorbol Acetate	215-246	tumor necrosis factor	Homo sapiens	156-183
26940200-4	2016	In this study, we demonstrate that mTOR inhibitors-rapamycin (RAP), temisirolimus (TEM), torin-1 (TOR) and PP242 suppress invasion and migration induced by Tumor Necrosis Factor-alpha (TNFalpha) and tumor promoter, Phorbol 12-myristate 13-acetate (PMA) and also reduce the expression of the TNFalpha and IL1beta suggesting their potential to regulate factors in microenvironment that support tumor progression.	Tetradecanoylphorbol Acetate	215-246	tumor necrosis factor	Homo sapiens	185-193
26739385-4	2016	Compound 8 exhibited inhibition of the secretion of IL-2 in phytohemagglutinin (PHA) and phorbol myristate acetate (PMA) stimulated Jurkat cells, and the IC50 value was 17.2 muM.	Tetradecanoylphorbol Acetate	116-119	interleukin 2	Homo sapiens	52-56
26826276-0	2016	The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus.	Tetradecanoylphorbol Acetate	14-45	GLI family zinc finger 2	Homo sapiens	98-103
26826276-2	2016	This is because, following differentiation using phorbol 12-myristate 13-acetate (PMA), THP-1 cells acquire a macrophage-like phenotype, which mimics, in many respects, primary human macrophages.	Tetradecanoylphorbol Acetate	49-80	GLI family zinc finger 2	Homo sapiens	88-93
26826276-2	2016	This is because, following differentiation using phorbol 12-myristate 13-acetate (PMA), THP-1 cells acquire a macrophage-like phenotype, which mimics, in many respects, primary human macrophages.	Tetradecanoylphorbol Acetate	82-85	GLI family zinc finger 2	Homo sapiens	88-93
26826276-8	2016	These data indicate that exposure of monocytic THP-1 cells to 25 nM PMA over 48 h, followed by a recovery period of 24h in culture in the absence of PMA, was the optimal protocol for the differentiation of THP-1 cells.	Tetradecanoylphorbol Acetate	68-71	GLI family zinc finger 2	Homo sapiens	47-52
26826276-8	2016	These data indicate that exposure of monocytic THP-1 cells to 25 nM PMA over 48 h, followed by a recovery period of 24h in culture in the absence of PMA, was the optimal protocol for the differentiation of THP-1 cells.	Tetradecanoylphorbol Acetate	68-71	GLI family zinc finger 2	Homo sapiens	206-211
26581877-6	2016	Our results indicate that confinement of p53 in the cytoplasm is one of the potential mechanisms by which TPA interferes with the process of radiation-induced apoptosis in human lymphocytes.	Tetradecanoylphorbol Acetate	106-109	tumor protein p53	Homo sapiens	41-44
26912086-0	2016	Regulations of Reversal of Senescence by PKC Isozymes in Response to 12-O-Tetradecanoylphorbol-13-Acetate via Nuclear Translocation of pErk1/2.	Tetradecanoylphorbol Acetate	69-105	proline rich transmembrane protein 2	Homo sapiens	41-44
26912086-2	2016	Upon TPA treatment, protein kinase C (PKC) alpha and PKCbeta1 exerted differential effects on the nuclear translocation of cytoplasmic pErk1/2, a protein which maintains senescence.	Tetradecanoylphorbol Acetate	5-8	protein kinase C alpha	Homo sapiens	20-48
26912086-5	2016	Repetitive exposure of mouse skin to TPA downregulated PKCalpha expression and increased epidermal and hair follicle cell proliferation.	Tetradecanoylphorbol Acetate	37-40	protein kinase C, alpha	Mus musculus	55-63
26912086-6	2016	Thus, PKCalpha downregulation is accompanied by in vivo cell proliferation, as evidenced in 7, 12-dimethylbenz(a)anthracene (DMBA)-TPA-mediated carcinogenesis.	Tetradecanoylphorbol Acetate	131-134	protein kinase C alpha	Homo sapiens	6-14
26912086-7	2016	The ability of TPA to reverse senescence was further demonstrated in old HDF cells using RNA-sequencing analyses in which TPA-induced nuclear PKCalpha degradation freed nuclear pErk1/2 to induce cell proliferation and facilitated the recovery of mitochondrial energy metabolism.	Tetradecanoylphorbol Acetate	15-18	protein kinase C alpha	Homo sapiens	142-150
26912086-7	2016	The ability of TPA to reverse senescence was further demonstrated in old HDF cells using RNA-sequencing analyses in which TPA-induced nuclear PKCalpha degradation freed nuclear pErk1/2 to induce cell proliferation and facilitated the recovery of mitochondrial energy metabolism.	Tetradecanoylphorbol Acetate	122-125	protein kinase C alpha	Homo sapiens	142-150
26912086-9	2016	Loss of PKCalpha expression following TPA treatment reduces pErk1/2-activated SP1 biding to the p21(WAF1) gene promoter, thus preventing senescence onset and overcoming G1/S cell cycle arrest in senescent cells.	Tetradecanoylphorbol Acetate	38-41	protein kinase C alpha	Homo sapiens	8-16
26912086-9	2016	Loss of PKCalpha expression following TPA treatment reduces pErk1/2-activated SP1 biding to the p21(WAF1) gene promoter, thus preventing senescence onset and overcoming G1/S cell cycle arrest in senescent cells.	Tetradecanoylphorbol Acetate	38-41	cyclin dependent kinase inhibitor 1A	Homo sapiens	96-99
26912086-9	2016	Loss of PKCalpha expression following TPA treatment reduces pErk1/2-activated SP1 biding to the p21(WAF1) gene promoter, thus preventing senescence onset and overcoming G1/S cell cycle arrest in senescent cells.	Tetradecanoylphorbol Acetate	38-41	cyclin dependent kinase inhibitor 1A	Homo sapiens	100-104
26874672-6	2016	Suplatast also suppressed ionomycin/phorbol-12-myristate-13-acetate-induced upregulation of IL-2 gene expression in Jurkat cells, in which calcineurin (CN)/nuclear factor of activated T-cells (NFAT) signaling is known to be involved.	Tetradecanoylphorbol Acetate	36-67	interleukin 2	Homo sapiens	92-96
26848699-5	2016	Although Snail family factors have been linked to inflammation via interactions with the cyclooxygenase-2 (COX-2) pathway, a pathway that also plays an important role in skin carcinogenesis, transient TPA induction of Slug and Snail appeared unrelated to COX-2 expression.	Tetradecanoylphorbol Acetate	201-204	snail family zinc finger 2	Mus musculus	218-222
26929603-7	2016	RESULTS: ANDRO ameliorated the increase in the intracellular calcium, protein, and messenger RNA levels of TSLP induced by phorbol myristate acetate/calcium ionophore A23187, through the blocking of the receptor-interacting protein 2/caspase-1/NF-kappaB pathway in human mast cell line 1 cells.	Tetradecanoylphorbol Acetate	123-148	caspase 1	Homo sapiens	234-243
26848699-3	2016	Slug and the related transcription factor Snail were expressed at high levels in skin tumors induced by 7,12-dimethylbenz[alpha]anthracene application followed by 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	163-199	snail family zinc finger 2	Mus musculus	0-4
26848699-3	2016	Slug and the related transcription factor Snail were expressed at high levels in skin tumors induced by 7,12-dimethylbenz[alpha]anthracene application followed by 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	201-204	snail family zinc finger 2	Mus musculus	0-4
26440050-5	2016	Here, we clone and express the novel TR3-iso2 protein and find that expression of TR3-iso2, in contrast to TR3-iso1, inhibits endothelial cell proliferation induced by VEGF-A, histamine, and phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	191-222	nuclear receptor subfamily 4 group A member 1	Homo sapiens	37-40
26440050-5	2016	Here, we clone and express the novel TR3-iso2 protein and find that expression of TR3-iso2, in contrast to TR3-iso1, inhibits endothelial cell proliferation induced by VEGF-A, histamine, and phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	191-222	nuclear receptor subfamily 4 group A member 1	Homo sapiens	82-85
26440050-5	2016	Here, we clone and express the novel TR3-iso2 protein and find that expression of TR3-iso2, in contrast to TR3-iso1, inhibits endothelial cell proliferation induced by VEGF-A, histamine, and phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	191-222	nuclear receptor subfamily 4 group A member 1	Homo sapiens	82-85
27551497-10	2016	Blocking the canonical NF-kappaB pathway suppressed TPA induction of TNFalpha in MDA-MB-468 cells whereas isolated downregulation of either the canonical or non-canonical pathways did not abolish the Smac mimetic induction of the NF-kappaB driven genes TNFalpha and BIRC3 in MDA-MB-231 cells although the absolute levels were suppressed.	Tetradecanoylphorbol Acetate	52-55	tumor necrosis factor	Homo sapiens	69-77
26848699-4	2016	TPA-induced transient elevation of Slug and Snail proteins in normal mouse epidermis and studies in Slug transgenic mice indicated that Slug modulates TPA-induced epidermal hyperplasia and cutaneous inflammation.	Tetradecanoylphorbol Acetate	0-3	snail family zinc finger 2	Mus musculus	35-39
26848699-6	2016	In cultured human keratinocytes, TPA induced Snail mRNA expression while suppressing Slug expression, and this differential regulation was due specifically to activation of the TPA receptor.	Tetradecanoylphorbol Acetate	33-36	snail family transcriptional repressor 1	Homo sapiens	45-50
26848699-4	2016	TPA-induced transient elevation of Slug and Snail proteins in normal mouse epidermis and studies in Slug transgenic mice indicated that Slug modulates TPA-induced epidermal hyperplasia and cutaneous inflammation.	Tetradecanoylphorbol Acetate	0-3	snail family zinc finger 2	Mus musculus	100-104
26848699-4	2016	TPA-induced transient elevation of Slug and Snail proteins in normal mouse epidermis and studies in Slug transgenic mice indicated that Slug modulates TPA-induced epidermal hyperplasia and cutaneous inflammation.	Tetradecanoylphorbol Acetate	0-3	snail family zinc finger 2	Mus musculus	100-104
26848699-4	2016	TPA-induced transient elevation of Slug and Snail proteins in normal mouse epidermis and studies in Slug transgenic mice indicated that Slug modulates TPA-induced epidermal hyperplasia and cutaneous inflammation.	Tetradecanoylphorbol Acetate	151-154	snail family zinc finger 2	Mus musculus	35-39
26851025-5	2016	To induce interleukin-2 (IL2) expression, cells were stimulated with phorbol 12-myristate 13-acetate/phytohemagglutinin.	Tetradecanoylphorbol Acetate	69-100	interleukin 2	Homo sapiens	10-23
26522807-12	2016	Monocytes preincubated with C16:0 increased secretion of pro-inflammatory cytokines in response to phorbol myristate acetate-induced differentiation through ceramide-dependent inhibition of PPARgamma activity.	Tetradecanoylphorbol Acetate	99-124	peroxisome proliferator activated receptor gamma	Homo sapiens	190-199
26851025-5	2016	To induce interleukin-2 (IL2) expression, cells were stimulated with phorbol 12-myristate 13-acetate/phytohemagglutinin.	Tetradecanoylphorbol Acetate	69-100	interleukin 2	Homo sapiens	25-28
26796274-4	2016	The short term exposure (3 days) of MCF-7 cells to TPA exhibited significant induction of Wnt5a expression, along with the enhanced expression of PKC-alpha, to promote cell migration, which suggested that activation of noncanonical Wnt signaling pathway is associated with PKC-alpha.	Tetradecanoylphorbol Acetate	51-54	Wnt family member 5A	Homo sapiens	90-95
26796274-4	2016	The short term exposure (3 days) of MCF-7 cells to TPA exhibited significant induction of Wnt5a expression, along with the enhanced expression of PKC-alpha, to promote cell migration, which suggested that activation of noncanonical Wnt signaling pathway is associated with PKC-alpha.	Tetradecanoylphorbol Acetate	51-54	protein kinase C alpha	Homo sapiens	146-155
26796274-4	2016	The short term exposure (3 days) of MCF-7 cells to TPA exhibited significant induction of Wnt5a expression, along with the enhanced expression of PKC-alpha, to promote cell migration, which suggested that activation of noncanonical Wnt signaling pathway is associated with PKC-alpha.	Tetradecanoylphorbol Acetate	51-54	protein kinase C alpha	Homo sapiens	273-282
26796274-5	2016	However, the chronic exposure (3 weeks) of cells to TPA completely suppressed Wnt5a expression and the expression of PKC-eta and PKC-delta, whereas the expression of Wnt3a and PKC-theta were up-regulated to activate the canonical Wnt signaling pathway.	Tetradecanoylphorbol Acetate	52-55	Wnt family member 5A	Homo sapiens	78-83
26796274-6	2016	Moreover, the loss of epithelial markers, including E-cadherin and GATA-3, suggested that chronic exposure of TPA stimulates EMT.	Tetradecanoylphorbol Acetate	110-113	cadherin 1	Homo sapiens	52-62
26786970-5	2016	According to immunohistochemical staining, Tat-SOD successfully suppressed inflammation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), the expression of sodium nitroferricyanide (SNP)-induced cyclooxygenase-2 (COX-2), and the production of nitrotyrosine proteins.	Tetradecanoylphorbol Acetate	99-135	superoxide dismutase 1	Homo sapiens	47-50
26718128-4	2016	Hispolon decreased the level of cellular ROS significantly and repressed TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK), accompanied by upregulation of E-cadherin and downregulation of the transcriptional repressor Slug.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase 1	Homo sapiens	104-141
26718128-4	2016	Hispolon decreased the level of cellular ROS significantly and repressed TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK), accompanied by upregulation of E-cadherin and downregulation of the transcriptional repressor Slug.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase 1	Homo sapiens	143-146
26718128-4	2016	Hispolon decreased the level of cellular ROS significantly and repressed TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK), accompanied by upregulation of E-cadherin and downregulation of the transcriptional repressor Slug.	Tetradecanoylphorbol Acetate	73-76	cadherin 1	Homo sapiens	180-190
26718128-5	2016	Furthermore, N-acetyl-cysteine, an antioxidant agent, markedly suppressed TPA-induced epithelial-to-mesenchymal transition, cell migration and activation of ERK.	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 1	Homo sapiens	157-160
26721363-8	2016	Treatment with Go6976 significantly ameliorated the PMA-induced oxidative stress parameters, decreased tissue TNF-alpha level, and lung edema.	Tetradecanoylphorbol Acetate	52-55	tumor necrosis factor	Rattus norvegicus	110-119
26749212-4	2016	The ectopic expression of Eomes induced BW5147 and EL4 cells to produce IFN-gamma in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	97-128	interferon gamma	Mus musculus	72-81
26749212-4	2016	The ectopic expression of Eomes induced BW5147 and EL4 cells to produce IFN-gamma in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	130-133	interferon gamma	Mus musculus	72-81
26927374-2	2016	METHODS: THP-1 cells were induced to differentiate into macrophages by 100 ng/mL phorbol 12-myristate 13-acetate (PMA) for 48 hours, and then the macrophages were further induced to generate foam cells by 50 mug/mL oxidized low-density lipoprotein (ox-LDL) and 1 mug/mL LPS.	Tetradecanoylphorbol Acetate	81-112	GLI family zinc finger 2	Homo sapiens	9-14
26927374-2	2016	METHODS: THP-1 cells were induced to differentiate into macrophages by 100 ng/mL phorbol 12-myristate 13-acetate (PMA) for 48 hours, and then the macrophages were further induced to generate foam cells by 50 mug/mL oxidized low-density lipoprotein (ox-LDL) and 1 mug/mL LPS.	Tetradecanoylphorbol Acetate	114-117	GLI family zinc finger 2	Homo sapiens	9-14
26786970-5	2016	According to immunohistochemical staining, Tat-SOD successfully suppressed inflammation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), the expression of sodium nitroferricyanide (SNP)-induced cyclooxygenase-2 (COX-2), and the production of nitrotyrosine proteins.	Tetradecanoylphorbol Acetate	137-140	superoxide dismutase 1	Homo sapiens	47-50
26631368-7	2016	The NFkappaB activators lipopolysaccharide and phorbol myristate acetate increased STS expression in undifferentiated and differentiated MG-63 cells, while the NFkappaB inhibitor BAY-11-7082 partially blocked these responses.	Tetradecanoylphorbol Acetate	47-72	nuclear factor kappa B subunit 1	Homo sapiens	4-12
26779131-10	2015	Co-incubation with a murine macrophage cell line J774a.1 or PMA-induced human monocytic cell line THP-1 demonstrated that mmar_2318 or mmar_2319 deletion mutant could grow in macrophages, and their initial entry rate was not affected in J774a.1 but significantly increased in THP-1.	Tetradecanoylphorbol Acetate	60-63	GLI family zinc finger 2	Homo sapiens	98-103
26779131-10	2015	Co-incubation with a murine macrophage cell line J774a.1 or PMA-induced human monocytic cell line THP-1 demonstrated that mmar_2318 or mmar_2319 deletion mutant could grow in macrophages, and their initial entry rate was not affected in J774a.1 but significantly increased in THP-1.	Tetradecanoylphorbol Acetate	60-63	GLI family zinc finger 2	Homo sapiens	276-281
26494252-7	2016	Addition of phorbol 12-myristate 13-acetate increased Erk activity leading to suppression of gstp1-2 mRNA.	Tetradecanoylphorbol Acetate	12-43	mitogen-activated protein kinase 1	Homo sapiens	54-57
26542395-6	2016	Currents demonstrated outward rectification and reversal at 0 mV (properties consistent with TMEM16A) and were inhibited by either molecular (siRNA) or pharmacologic (PMA or Go6976) inhibition of PKCalpha.	Tetradecanoylphorbol Acetate	167-170	protein kinase C alpha	Homo sapiens	196-204
26498044-4	2016	METHODS: Phorbol 12-myristate-13-acetate (PMA)-induced PKC activation and ankyrin phosphorylation were tested, and under different treatment conditions the subpopulation of erythrocytes with ankyrin exposure and the levels of intracellular calcium were analyzed by flow cytometry.	Tetradecanoylphorbol Acetate	9-40	proline rich transmembrane protein 2	Homo sapiens	55-58
26498044-4	2016	METHODS: Phorbol 12-myristate-13-acetate (PMA)-induced PKC activation and ankyrin phosphorylation were tested, and under different treatment conditions the subpopulation of erythrocytes with ankyrin exposure and the levels of intracellular calcium were analyzed by flow cytometry.	Tetradecanoylphorbol Acetate	42-45	proline rich transmembrane protein 2	Homo sapiens	55-58
26498044-8	2016	PKC inhibition with chelerythrine chloride, an inhibitor of the active site, diminished the level of ankyrin-exposing cells and ankyrin phosphorylation; however it even led to a higher percentage of cells with increased levels of calcium than with PMA treatment alone.	Tetradecanoylphorbol Acetate	248-251	proline rich transmembrane protein 2	Homo sapiens	0-3
27476935-4	2016	In contrast, p-cymene enhanced the TPA-augmented production and gene expression of TIMP-1 in HT-1080 cells.	Tetradecanoylphorbol Acetate	35-38	TIMP metallopeptidase inhibitor 1	Homo sapiens	83-89
27476935-7	2016	Furthermore, p-cymene was found to suppress the constitutive and/or TPA-augmented phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and p38 mitogen-activated protein kinase (MAPK) in HT-1080 cells.	Tetradecanoylphorbol Acetate	68-71	mitogen-activated protein kinase 1	Homo sapiens	101-147
27476935-7	2016	Furthermore, p-cymene was found to suppress the constitutive and/or TPA-augmented phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and p38 mitogen-activated protein kinase (MAPK) in HT-1080 cells.	Tetradecanoylphorbol Acetate	68-71	mitogen-activated protein kinase 14	Homo sapiens	152-188
27476935-7	2016	Furthermore, p-cymene was found to suppress the constitutive and/or TPA-augmented phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and p38 mitogen-activated protein kinase (MAPK) in HT-1080 cells.	Tetradecanoylphorbol Acetate	68-71	mitogen-activated protein kinase 3	Homo sapiens	190-194
27889764-5	2016	METHODS: We primed THP-1 cells with phorbol-12-myristate-13-acetate (PMA) for differentiation, then exposed cells to HUA and detected the production of reactive oxygen species (ROS) and analyzed the level of phospho-AMPKalpha.	Tetradecanoylphorbol Acetate	36-67	GLI family zinc finger 2	Homo sapiens	19-24
27889764-5	2016	METHODS: We primed THP-1 cells with phorbol-12-myristate-13-acetate (PMA) for differentiation, then exposed cells to HUA and detected the production of reactive oxygen species (ROS) and analyzed the level of phospho-AMPKalpha.	Tetradecanoylphorbol Acetate	69-72	GLI family zinc finger 2	Homo sapiens	19-24
27771709-9	2016	RESULTS: The percentage of RBCs showing PS exposure after activation with LPA, PMA, or A23187 is significantly reduced after inhibition of the scramblase using the specific inhibitor R5421 as well as after the inhibition of the PKCalpha using chelerythrine chloride or calphostin C.	Tetradecanoylphorbol Acetate	79-82	protein kinase C alpha	Homo sapiens	228-236
26619301-5	2016	MBCA suppressed PMA- and histamine-induced upregulation of H1R expression at both mRNA and protein levels and inhibited PMA-induced phosphorylation of PKCdelta at Tyr(311) and subsequent translocation to the Golgi.	Tetradecanoylphorbol Acetate	16-19	histamine receptor H 1	Rattus norvegicus	59-62
25865025-5	2016	Human umbilical vein endothelial cell (HUVEC) cultures were stimulated to express VEGF by 10 nM phorbol-12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	96-127	vascular endothelial growth factor A	Homo sapiens	82-86
26717978-8	2016	The results indicated that the PJT-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involved the suppression of the PKCalpha/NF-kappaB pathway in MCF-7 cells.	Tetradecanoylphorbol Acetate	58-61	protein kinase C alpha	Homo sapiens	137-145
26718326-5	2016	We noted that the purified nonameric peptide (AIGIDP) attenuated the phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced histamine release and the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in human mast cells (HMC-1 cells).	Tetradecanoylphorbol Acetate	69-100	tumor necrosis factor	Homo sapiens	223-250
26718326-5	2016	We noted that the purified nonameric peptide (AIGIDP) attenuated the phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced histamine release and the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in human mast cells (HMC-1 cells).	Tetradecanoylphorbol Acetate	69-100	tumor necrosis factor	Homo sapiens	252-261
26718326-5	2016	We noted that the purified nonameric peptide (AIGIDP) attenuated the phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced histamine release and the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in human mast cells (HMC-1 cells).	Tetradecanoylphorbol Acetate	69-100	interleukin 1 beta	Homo sapiens	264-286
26718326-5	2016	We noted that the purified nonameric peptide (AIGIDP) attenuated the phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced histamine release and the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in human mast cells (HMC-1 cells).	Tetradecanoylphorbol Acetate	69-100	interleukin 6	Homo sapiens	291-295
25865025-5	2016	Human umbilical vein endothelial cell (HUVEC) cultures were stimulated to express VEGF by 10 nM phorbol-12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	129-132	vascular endothelial growth factor A	Homo sapiens	82-86
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	41-72	proline rich transmembrane protein 2	Homo sapiens	27-30
26651527-5	2015	This inhibitory effect was associated with inhibition on TPA-induced up-regulation of pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 beta	Mus musculus	113-121
26651527-5	2015	This inhibitory effect was associated with inhibition on TPA-induced up-regulation of pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	Tetradecanoylphorbol Acetate	57-60	interleukin 6	Mus musculus	123-127
26651527-5	2015	This inhibitory effect was associated with inhibition on TPA-induced up-regulation of pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	Tetradecanoylphorbol Acetate	57-60	tumor necrosis factor	Mus musculus	133-142
26573554-7	2016	In human mast cells, sesamin reduced the stimulatory effects of phorbol 12-myristate 13-acetate and calcium ionophore A23187 on the production and secretion of pro-inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-6.	Tetradecanoylphorbol Acetate	64-95	tumor necrosis factor	Homo sapiens	198-225
26573554-7	2016	In human mast cells, sesamin reduced the stimulatory effects of phorbol 12-myristate 13-acetate and calcium ionophore A23187 on the production and secretion of pro-inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-6.	Tetradecanoylphorbol Acetate	64-95	interleukin 6	Homo sapiens	230-243
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	41-72	solute carrier family 10 member 1	Homo sapiens	189-193
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	41-72	solute carrier family 22 member 1	Homo sapiens	195-199
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	41-72	solute carrier organic anion transporter family member 1B3	Homo sapiens	234-241
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	41-72	ATP binding cassette subfamily B member 1	Homo sapiens	321-325
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	74-77	proline rich transmembrane protein 2	Homo sapiens	27-30
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	74-77	solute carrier family 10 member 1	Homo sapiens	189-193
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	74-77	solute carrier family 22 member 1	Homo sapiens	195-199
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	74-77	solute carrier organic anion transporter family member 1B3	Homo sapiens	234-241
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	74-77	ATP binding cassette subfamily B member 1	Homo sapiens	321-325
26462574-5	2015	The profile of hepatic transporter mRNA expression changes in PMA-treated HepaRG cells was correlated to that found in PMA-exposed primary human hepatocytes and was similarly observed in response to the PKC-activating marketed drug ingenol mebutate.	Tetradecanoylphorbol Acetate	62-65	proline rich transmembrane protein 2	Homo sapiens	203-206
26345246-3	2015	It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	143-146	interleukin 1 beta	Mus musculus	155-172
26345246-3	2015	It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	143-146	interleukin 6	Mus musculus	185-198
26455269-5	2015	Our data showed that 6-O inhibited PMA induced interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha expression in THP-1 monocytic cells.	Tetradecanoylphorbol Acetate	35-38	tumor necrosis factor	Homo sapiens	74-107
26345246-3	2015	It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	143-146	interleukin 1 beta	Mus musculus	174-182
26345246-3	2015	It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	143-146	interleukin 6	Mus musculus	200-228
26345246-3	2015	It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	143-146	tumor necrosis factor	Mus musculus	230-239
26475020-5	2015	During phorbol myristate acetate (PMA)-activation of HDLECs, miR-132 is induced in a CREB-dependent manner and inhibition of miR-132 results in increased AGO2 expression.	Tetradecanoylphorbol Acetate	7-32	argonaute RISC catalytic component 2	Homo sapiens	154-158
26475020-5	2015	During phorbol myristate acetate (PMA)-activation of HDLECs, miR-132 is induced in a CREB-dependent manner and inhibition of miR-132 results in increased AGO2 expression.	Tetradecanoylphorbol Acetate	34-37	argonaute RISC catalytic component 2	Homo sapiens	154-158
26404773-8	2015	In contrast, activation of the PKC system by phorbol 12-myristate 13-acetate (PMA) exerted inhibitory actions on TRPC6 and suppressed its expression.	Tetradecanoylphorbol Acetate	45-76	protein kinase C alpha	Homo sapiens	31-34
25994902-0	2015	Essential Role of Lysophosphatidylcholine Acyltransferase 3 in the Induction of Macrophage Polarization in PMA-Treated U937 Cells.	Tetradecanoylphorbol Acetate	107-110	lysophosphatidylcholine acyltransferase 3	Homo sapiens	18-59
25994902-8	2015	LPS significantly downregulated the mRNA expression of LPCAT3, one of four LPCAT isoforms, and suppressed its enzymatic activity toward linoleoyl-CoA and arachidonoyl-CoA in PMA-treated U937 cells.	Tetradecanoylphorbol Acetate	174-177	lysophosphatidylcholine acyltransferase 3	Homo sapiens	55-61
25994902-8	2015	LPS significantly downregulated the mRNA expression of LPCAT3, one of four LPCAT isoforms, and suppressed its enzymatic activity toward linoleoyl-CoA and arachidonoyl-CoA in PMA-treated U937 cells.	Tetradecanoylphorbol Acetate	174-177	lysophosphatidylcholine acyltransferase 3	Homo sapiens	55-60
26404773-8	2015	In contrast, activation of the PKC system by phorbol 12-myristate 13-acetate (PMA) exerted inhibitory actions on TRPC6 and suppressed its expression.	Tetradecanoylphorbol Acetate	78-81	protein kinase C alpha	Homo sapiens	31-34
26404773-9	2015	Importantly, PMA treatment markedly down-regulated the expression levels of PKCalpha, PKCbeta, and PKCeta reflecting their activation.	Tetradecanoylphorbol Acetate	13-16	protein kinase C alpha	Homo sapiens	76-84
26310443-0	2015	Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis.	Tetradecanoylphorbol Acetate	51-54	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	19-25
26498639-11	2015	The levels of MMP-2, MMP-9, E-cad and integrin beta1 in the TPA-induced A549 cells changed markedly, compared with the untreated cells.	Tetradecanoylphorbol Acetate	60-63	cadherin 1	Homo sapiens	28-33
26516703-7	2015	Using an IL-32theta stable expression system in leukemia cell lines, we found that IL-32theta attenuated phorbol 12-myristate 13-acetate (PMA)-induced TNF-alpha production.	Tetradecanoylphorbol Acetate	105-136	tumor necrosis factor	Homo sapiens	151-160
26516703-7	2015	Using an IL-32theta stable expression system in leukemia cell lines, we found that IL-32theta attenuated phorbol 12-myristate 13-acetate (PMA)-induced TNF-alpha production.	Tetradecanoylphorbol Acetate	138-141	tumor necrosis factor	Homo sapiens	151-160
26391622-11	2015	eIF6 is a translation factor acting downstream of insulin/phorbol 12-myristate 13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	58-89	eukaryotic translation initiation factor 6	Mus musculus	0-4
26391622-11	2015	eIF6 is a translation factor acting downstream of insulin/phorbol 12-myristate 13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	91-94	eukaryotic translation initiation factor 6	Mus musculus	0-4
26459032-3	2015	The neutrophil NADPH-oxidase can be activated at different cellular sites and ROS may be produced and processed by MPO within intracellular granules, even in situations where a phagosome is not formed, e.g., upon stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	230-255	myeloperoxidase	Homo sapiens	115-118
26459032-3	2015	The neutrophil NADPH-oxidase can be activated at different cellular sites and ROS may be produced and processed by MPO within intracellular granules, even in situations where a phagosome is not formed, e.g., upon stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	257-260	myeloperoxidase	Homo sapiens	115-118
26582014-1	2015	Previous analyses have reported that the human monocytic cell line THP1 can be differentiated into cells with macrophage-like characteristics by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	145-176	GLI family zinc finger 2	Homo sapiens	67-71
26582014-1	2015	Previous analyses have reported that the human monocytic cell line THP1 can be differentiated into cells with macrophage-like characteristics by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	178-181	GLI family zinc finger 2	Homo sapiens	67-71
26580203-6	2015	We also show that in keratinocytes the PMA-stimulated phosphorylation of beta4-T1736 primarily is mediated by PKD2 activation downstream of PKCdelta.	Tetradecanoylphorbol Acetate	39-42	polycystin 2, transient receptor potential cation channel	Homo sapiens	110-114
26133738-9	2015	In the parallel experiments, we demonstrated that TG2 inhibition reduced RANKL expression in both HPDL cells from CP patients and monocytes differentiated to macrophages by tetradecanoyl phorbol acetate treatment.	Tetradecanoylphorbol Acetate	173-202	transglutaminase 2	Homo sapiens	50-53
25825272-4	2015	Phorbol 12-myristate 13-acetate, a PKC activator, decreased claudin-2 expression.	Tetradecanoylphorbol Acetate	0-31	claudin 2	Canis lupus familiaris	60-69
26485540-7	2015	To confirm the inhibition of Akt1 phosphorylation, MCF10A cell line was co-treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) and 100 muM of each of the most potent 13 Akt inhibitors (1-13).	Tetradecanoylphorbol Acetate	126-129	AKT serine/threonine kinase 1	Homo sapiens	29-33
26430963-4	2015	The re-expression of COX-2 was observed after 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment in both cell lines.	Tetradecanoylphorbol Acetate	46-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	21-26
26430963-4	2015	The re-expression of COX-2 was observed after 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment in both cell lines.	Tetradecanoylphorbol Acetate	84-87	prostaglandin-endoperoxide synthase 2	Homo sapiens	21-26
26430963-5	2015	Further investigation found that H3K36 dimethylation was significantly reduced near the COX-2 promoter because histone demethylase 2A (KDM2A) was recruited to the COX-2 promoter after TPA treatment.	Tetradecanoylphorbol Acetate	184-187	prostaglandin-endoperoxide synthase 2	Homo sapiens	88-93
26430963-5	2015	Further investigation found that H3K36 dimethylation was significantly reduced near the COX-2 promoter because histone demethylase 2A (KDM2A) was recruited to the COX-2 promoter after TPA treatment.	Tetradecanoylphorbol Acetate	184-187	prostaglandin-endoperoxide synthase 2	Homo sapiens	163-168
26430963-6	2015	In addition, the transcription factor c-Fos was found to be required to recruit KDM2A to the COX-2 promoter for reactivation of COX-2 in response to TPA treatment in both the H719 and H460 cell lines.	Tetradecanoylphorbol Acetate	149-152	prostaglandin-endoperoxide synthase 2	Homo sapiens	93-98
26430963-6	2015	In addition, the transcription factor c-Fos was found to be required to recruit KDM2A to the COX-2 promoter for reactivation of COX-2 in response to TPA treatment in both the H719 and H460 cell lines.	Tetradecanoylphorbol Acetate	149-152	prostaglandin-endoperoxide synthase 2	Homo sapiens	128-133
26430963-7	2015	Together, our data reveal a novel mechanism by which the carcinogen TPA activates COX-2 expression by regulating H3K36 dimethylation near the COX-2 promoter.	Tetradecanoylphorbol Acetate	68-71	prostaglandin-endoperoxide synthase 2	Homo sapiens	82-87
26430963-7	2015	Together, our data reveal a novel mechanism by which the carcinogen TPA activates COX-2 expression by regulating H3K36 dimethylation near the COX-2 promoter.	Tetradecanoylphorbol Acetate	68-71	prostaglandin-endoperoxide synthase 2	Homo sapiens	142-147
26372376-7	2015	Secondly, autophagy is activated during PMA-induced THP-1 monocyte differentiation, and the autophagy inhibitor chloroquine (CQ) can inhibit this process.	Tetradecanoylphorbol Acetate	40-43	GLI family zinc finger 2	Homo sapiens	52-57
26310443-5	2015	Here we show that loss of the endogenous expression of Nfatc1 suppresses the rate of DMBA/TPA-induced skin tumorigenesis.	Tetradecanoylphorbol Acetate	90-93	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	55-61
26438830-4	2015	In murine bone marrow-derived macrophages and murine embryonic fibroblasts stimulated with their cognate growth factors or with phorbol myristate acetate, activation of mTORC1 required an Akt-independent vesicular pathway of amino acid delivery into endolysosomes, mediated by the actin cytoskeleton.	Tetradecanoylphorbol Acetate	128-153	thymoma viral proto-oncogene 1	Mus musculus	188-191
26101063-0	2015	Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways.	Tetradecanoylphorbol Acetate	18-21	protein kinase C alpha	Homo sapiens	112-115
26269597-0	2015	ERK2-Pyruvate Kinase Axis Permits Phorbol 12-Myristate 13-Acetate-induced Megakaryocyte Differentiation in K562 Cells.	Tetradecanoylphorbol Acetate	34-65	mitogen-activated protein kinase 1	Homo sapiens	0-4
26431317-7	2015	Further analysis revealed that TPA+UVC co-exposure caused synergistic perturbation of specific genes associated with p53, AP-1 and inflammatory pathways important in carcinogenesis.	Tetradecanoylphorbol Acetate	31-34	tumor protein p53	Homo sapiens	117-120
26241492-6	2015	We found that PMA-induced megakaryocytic differentiation in myeloid leukemia cells is accompanied by cell death and SOD1 down-regulation, while SOD2 expression is not affected.	Tetradecanoylphorbol Acetate	14-17	superoxide dismutase 1	Homo sapiens	116-120
26241492-7	2015	The role of SOD1 is verified when ATN-224, a SOD1 specific inhibitor, inhibits cell proliferation and promotes cell death in myeloid leukemia cells without PMA treatment.	Tetradecanoylphorbol Acetate	156-159	superoxide dismutase 1	Homo sapiens	12-16
26664025-10	2015	In addition, XF inhibited the phosphorylation of IkappaB-alpha and NF-kappaB in phorbol-myristate-acetate plus calcium ionophore A23187 (A23187) stimulated HMC-1.	Tetradecanoylphorbol Acetate	80-105	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	49-62
26664025-10	2015	In addition, XF inhibited the phosphorylation of IkappaB-alpha and NF-kappaB in phorbol-myristate-acetate plus calcium ionophore A23187 (A23187) stimulated HMC-1.	Tetradecanoylphorbol Acetate	80-105	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	67-76
26269597-8	2015	In addition to metabolic effects, PMA treatment also translocated PKM2, but not PKR, into nucleus.	Tetradecanoylphorbol Acetate	34-37	pyruvate kinase L/R	Homo sapiens	80-83
26231140-7	2015	These compounds appeared the most effective inducers of p53 in the TPA-challenged neutrophils, what may suggest that pro-apoptotic activity of these stilbenes might be related to p53 activation.	Tetradecanoylphorbol Acetate	67-70	tumor protein p53	Homo sapiens	56-59
26231140-7	2015	These compounds appeared the most effective inducers of p53 in the TPA-challenged neutrophils, what may suggest that pro-apoptotic activity of these stilbenes might be related to p53 activation.	Tetradecanoylphorbol Acetate	67-70	tumor protein p53	Homo sapiens	179-182
26269597-4	2015	Here we studied the role of PK in phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic differentiation in human leukemia K562 cells.	Tetradecanoylphorbol Acetate	34-65	pyruvate kinase L/R	Homo sapiens	28-30
26269597-4	2015	Here we studied the role of PK in phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic differentiation in human leukemia K562 cells.	Tetradecanoylphorbol Acetate	67-70	pyruvate kinase L/R	Homo sapiens	28-30
26269597-6	2015	Interestingly, silencing of PK (PKM2 and PKR) inhibited PMA-induced megakaryocytic differentiation, as revealed by decreased expression of megakaryocytic differentiation marker CD61 and cell cycle behavior.	Tetradecanoylphorbol Acetate	56-59	pyruvate kinase L/R	Homo sapiens	28-30
26269597-6	2015	Interestingly, silencing of PK (PKM2 and PKR) inhibited PMA-induced megakaryocytic differentiation, as revealed by decreased expression of megakaryocytic differentiation marker CD61 and cell cycle behavior.	Tetradecanoylphorbol Acetate	56-59	pyruvate kinase L/R	Homo sapiens	41-44
26269597-6	2015	Interestingly, silencing of PK (PKM2 and PKR) inhibited PMA-induced megakaryocytic differentiation, as revealed by decreased expression of megakaryocytic differentiation marker CD61 and cell cycle behavior.	Tetradecanoylphorbol Acetate	56-59	integrin subunit beta 3	Homo sapiens	177-181
26269597-7	2015	Further, PMA-induced ATP production reduced greatly upon PK silencing, suggesting that PK is required for ATP synthesis.	Tetradecanoylphorbol Acetate	9-12	pyruvate kinase L/R	Homo sapiens	57-59
26269597-7	2015	Further, PMA-induced ATP production reduced greatly upon PK silencing, suggesting that PK is required for ATP synthesis.	Tetradecanoylphorbol Acetate	9-12	pyruvate kinase L/R	Homo sapiens	87-89
26377185-5	2015	The contribution of the conventional Gi/Go, Gz and AKT/beta-Arrestin pathways in the VEGF regulation was assessed by adding pertussis toxin (PTX), phorbol 12-myristate 13-acetate (PMA), or wortmannin (WT).	Tetradecanoylphorbol Acetate	180-183	vascular endothelial growth factor A	Homo sapiens	85-89
26157065-2	2015	To this end, changes in the inflammatory profiles of lipopolysacchride (LPS)-stimulated phrobol 12-myristate 13-acetate(PMA)-differented THP-1 macrophages were evaluated following Chi IVa treatment.	Tetradecanoylphorbol Acetate	120-123	GLI family zinc finger 2	Homo sapiens	137-142
26335138-3	2015	RESULTS: The peripheral Th1/Th2 was detected by Ionomycin and phorbol myristate acetate (PMA)-stimulating peripheral blood mononuclear cells (PBMC) of phase pregnant mice.	Tetradecanoylphorbol Acetate	62-87	negative elongation factor complex member C/D, Th1l	Mus musculus	24-27
26335138-3	2015	RESULTS: The peripheral Th1/Th2 was detected by Ionomycin and phorbol myristate acetate (PMA)-stimulating peripheral blood mononuclear cells (PBMC) of phase pregnant mice.	Tetradecanoylphorbol Acetate	89-92	negative elongation factor complex member C/D, Th1l	Mus musculus	24-27
26003841-5	2015	The S-tagged C5a-induced agonistic effects on chemotaxis, cytoplasmic Ca(2+) influx and p38 mitogen-activated protein kinase phosphorylation were not changed by Lf knockdown and deltaLf overexpression in neutrophil-like or macrophage-like cells, which were differentiated into mature cells from human promyelocytic leukemia HL-60 cells by dimethyl sulfoxide and phorbol-12-myristate-13-acetate, respectively.	Tetradecanoylphorbol Acetate	362-393	complement C5a receptor 1	Homo sapiens	13-16
26033110-4	2015	PKC activation by phorbol 12-myristate 13-acetate causes cortactin phosphorylation, filopodial retraction and F-actin-bundle loss.	Tetradecanoylphorbol Acetate	18-49	protein kinase C alpha	Homo sapiens	0-3
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	Tetradecanoylphorbol Acetate	56-59	signal transducer and activator of transcription 3	Mus musculus	104-109
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	Tetradecanoylphorbol Acetate	56-59	thymoma viral proto-oncogene 1	Mus musculus	116-119
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	Tetradecanoylphorbol Acetate	56-59	programmed cell death 4	Mus musculus	234-239
26183538-7	2015	Simultaneous treatment of zymosan and PMA enhanced the nuclear translocation of NF-kappaB subunits, p50 and p65, mediating the increase of TNF-alpha production.	Tetradecanoylphorbol Acetate	38-41	nuclear factor kappa B subunit 1	Homo sapiens	100-103
26183538-7	2015	Simultaneous treatment of zymosan and PMA enhanced the nuclear translocation of NF-kappaB subunits, p50 and p65, mediating the increase of TNF-alpha production.	Tetradecanoylphorbol Acetate	38-41	tumor necrosis factor	Homo sapiens	139-148
26183538-8	2015	Bay 11-7082, an NF-kappaB inhibitor, blocked morphological changes and TNF-alpha production induced by zymosan and/or PMA treatment.	Tetradecanoylphorbol Acetate	118-121	tumor necrosis factor	Homo sapiens	71-80
26240345-7	2015	In young mice, Sod2 deficiency accelerated epidermal thinning in response to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate, phenocopying the reduced regeneration of older Sod2-deficient skin.	Tetradecanoylphorbol Acetate	96-132	superoxide dismutase 2, mitochondrial	Mus musculus	15-19
27057457-6	2016	Using a highly metastatic Hgf-Cdk4(R24C) melanoma skin transplant we could show that TPA enhances systemic spread of melanoma cells which was depended on intact TLR4 signaling in recipient mice and on the presence of neutrophils.	Tetradecanoylphorbol Acetate	85-88	cyclin-dependent kinase 4	Mus musculus	30-34
27057457-6	2016	Using a highly metastatic Hgf-Cdk4(R24C) melanoma skin transplant we could show that TPA enhances systemic spread of melanoma cells which was depended on intact TLR4 signaling in recipient mice and on the presence of neutrophils.	Tetradecanoylphorbol Acetate	85-88	toll-like receptor 4	Mus musculus	161-165
26284516-7	2015	Remarkably, Pelingo juice inhibited the 12-o-tetra-decanoyl-phorbol-13-acetate (TPA)-induced tumorigenesis of JB6 P+ cells, suppressing colony formation in semi-solid medium and TPA-induced ERK1/2 phosphorylation.	Tetradecanoylphorbol Acetate	80-83	mitogen-activated protein kinase 3	Homo sapiens	190-196
26268522-9	2015	CD4+CD25+ enriched PBL stimulated with PMA/Ionomycin in the presence of rIFNgamma were rather resistant to the effect of rIFNgamma, in contrast to CD4+CD25- enriched PBL which showed increasing total Treg with Helios+ Treg switching from IFNgamma- to IFNgamma+ and increasing Helios-IFNgamma+ Treg.	Tetradecanoylphorbol Acetate	39-42	CD4 molecule	Homo sapiens	0-3
26268522-9	2015	CD4+CD25+ enriched PBL stimulated with PMA/Ionomycin in the presence of rIFNgamma were rather resistant to the effect of rIFNgamma, in contrast to CD4+CD25- enriched PBL which showed increasing total Treg with Helios+ Treg switching from IFNgamma- to IFNgamma+ and increasing Helios-IFNgamma+ Treg.	Tetradecanoylphorbol Acetate	39-42	interferon gamma	Homo sapiens	73-81
26268522-11	2015	When phorbol 12-myristate 13-acetate (PMA)/Ionomycin was washed out from the cell culture after 6 h stimulation, Treg induction continued for at least 96 h of cell culture, contradicting the hypothesis that removal of the stimulus results in significant decrease of IFNgamma- and IFNgamma+ CD4+CD25+Foxp3+CD127- Treg due to loss of Foxp3 expression.	Tetradecanoylphorbol Acetate	5-36	interferon gamma	Homo sapiens	266-288
26268522-11	2015	When phorbol 12-myristate 13-acetate (PMA)/Ionomycin was washed out from the cell culture after 6 h stimulation, Treg induction continued for at least 96 h of cell culture, contradicting the hypothesis that removal of the stimulus results in significant decrease of IFNgamma- and IFNgamma+ CD4+CD25+Foxp3+CD127- Treg due to loss of Foxp3 expression.	Tetradecanoylphorbol Acetate	5-36	CD4 molecule	Homo sapiens	290-293
26268522-11	2015	When phorbol 12-myristate 13-acetate (PMA)/Ionomycin was washed out from the cell culture after 6 h stimulation, Treg induction continued for at least 96 h of cell culture, contradicting the hypothesis that removal of the stimulus results in significant decrease of IFNgamma- and IFNgamma+ CD4+CD25+Foxp3+CD127- Treg due to loss of Foxp3 expression.	Tetradecanoylphorbol Acetate	38-41	interferon gamma	Homo sapiens	266-288
26268522-11	2015	When phorbol 12-myristate 13-acetate (PMA)/Ionomycin was washed out from the cell culture after 6 h stimulation, Treg induction continued for at least 96 h of cell culture, contradicting the hypothesis that removal of the stimulus results in significant decrease of IFNgamma- and IFNgamma+ CD4+CD25+Foxp3+CD127- Treg due to loss of Foxp3 expression.	Tetradecanoylphorbol Acetate	38-41	CD4 molecule	Homo sapiens	290-293
25537181-8	2015	This study for the first time demonstrates a major neuroprotective role for IL-10(+) B-cells in treating MCAO in male WT mice at a time point well beyond the ~4 h tPA treatment window, leading to the generation of a dominant IL-10(+)CD8(+)CD122(+) Treg population associated with spleen preservation and reduced CNS inflammation.	Tetradecanoylphorbol Acetate	163-166	interleukin 10	Mus musculus	76-81
26218692-8	2015	METHODS: Isolated human PMNs were incubated with the PLA2 inhibitor selective for iPLA2beta, iPLA2gamma, or cPLA2 and then activated with formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	186-217	phospholipase A2 group VI	Homo sapiens	53-57
26218692-8	2015	METHODS: Isolated human PMNs were incubated with the PLA2 inhibitor selective for iPLA2beta, iPLA2gamma, or cPLA2 and then activated with formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	219-222	phospholipase A2 group VI	Homo sapiens	53-57
26253167-5	2015	METHODS: We set up a model of macrophage polarization, starting from THP-1 monocytes differentiated into macrophages using PMA (Phorbol 12-myristate 13-acetate).	Tetradecanoylphorbol Acetate	128-159	GLI family zinc finger 2	Homo sapiens	69-74
26096873-7	2015	Using these parameters, we present an example of sequential fluorescence and bioluminescence microscopic observation of signal transduction (translocation of protein kinase C alpha from the cytoplasm to the plasma membrane) coupled with activation of gene expression by nuclear factor of kappa light polypeptide B in individual cells and show that the gene expression response is not completely concordant with upstream signaling following stimulation with phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	457-488	protein kinase C alpha	Homo sapiens	158-180
26668998-7	2015	In vitro, levels of AMPKalpha phosphorylation in phorbol-12- myristate-13-acetate (PMA) differentiated THP-1 cells was detected by immunohistochemistry, IL-8 level in supernatants of cigarette smoke condensate stimulating PMA differentiated THP-1 cells was measured by ELISA.	Tetradecanoylphorbol Acetate	49-81	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
26222138-0	2015	NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages.	Tetradecanoylphorbol Acetate	36-67	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
26220523-7	2015	On the mechanism, the phosphorylation mediated by LK6 and Mnk2a is controlled through ERK signal pathway by phorbolmyristate acetate (PMA) avtivation and PD98059 inhibition.	Tetradecanoylphorbol Acetate	108-132	mitogen-activated protein kinase 1	Homo sapiens	86-89
26220523-7	2015	On the mechanism, the phosphorylation mediated by LK6 and Mnk2a is controlled through ERK signal pathway by phorbolmyristate acetate (PMA) avtivation and PD98059 inhibition.	Tetradecanoylphorbol Acetate	134-137	mitogen-activated protein kinase 1	Homo sapiens	86-89
26222138-0	2015	NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages.	Tetradecanoylphorbol Acetate	69-72	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
26222138-7	2015	In addition, PMA-inducible secretion of monocyte chemotactic protein 1 (MCP-1) was significantly high in NRF2-silenced U937.	Tetradecanoylphorbol Acetate	13-16	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
26222138-10	2015	Taken together, our results suggest that the NRF2 system functions to suppress PMA-stimulated U937 cell differentiation into pro-inflammatory macrophages and provide evidence that the ROS-PKCalpha-ERK-NFkB axis is involved in PMA-facilitated differentiation of NRF2-silenced U937 cells.	Tetradecanoylphorbol Acetate	79-82	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
26222138-10	2015	Taken together, our results suggest that the NRF2 system functions to suppress PMA-stimulated U937 cell differentiation into pro-inflammatory macrophages and provide evidence that the ROS-PKCalpha-ERK-NFkB axis is involved in PMA-facilitated differentiation of NRF2-silenced U937 cells.	Tetradecanoylphorbol Acetate	79-82	protein kinase C alpha	Homo sapiens	188-196
26222138-10	2015	Taken together, our results suggest that the NRF2 system functions to suppress PMA-stimulated U937 cell differentiation into pro-inflammatory macrophages and provide evidence that the ROS-PKCalpha-ERK-NFkB axis is involved in PMA-facilitated differentiation of NRF2-silenced U937 cells.	Tetradecanoylphorbol Acetate	79-82	mitogen-activated protein kinase 1	Homo sapiens	197-200
26222138-10	2015	Taken together, our results suggest that the NRF2 system functions to suppress PMA-stimulated U937 cell differentiation into pro-inflammatory macrophages and provide evidence that the ROS-PKCalpha-ERK-NFkB axis is involved in PMA-facilitated differentiation of NRF2-silenced U937 cells.	Tetradecanoylphorbol Acetate	79-82	NFE2 like bZIP transcription factor 2	Homo sapiens	261-265
25109682-5	2015	The treatment of THP-1 monocytes using phorbol 12-myristate 13-acetate (PMA) was shown to initiate inflammatory responses.	Tetradecanoylphorbol Acetate	39-70	GLI family zinc finger 2	Homo sapiens	17-22
25979951-8	2015	NET formation after stimulation with platelet activating factor, ionomycin, or phorbol 12-myristate 13-acetate was significantly enhanced, indicating that the P-selectin(DeltaCT/DeltaCT) neutrophils were primed for NETosis.	Tetradecanoylphorbol Acetate	79-110	selectin, platelet	Mus musculus	159-169
26133397-4	2015	Contrary to this, using mice with a deletion of the R-ras gene, we found that R-Ras facilitates DMBA/TPA-induced skin tumour induction.	Tetradecanoylphorbol Acetate	101-104	related RAS viral (r-ras) oncogene	Mus musculus	52-57
26133397-4	2015	Contrary to this, using mice with a deletion of the R-ras gene, we found that R-Ras facilitates DMBA/TPA-induced skin tumour induction.	Tetradecanoylphorbol Acetate	101-104	related RAS viral (r-ras) oncogene	Mus musculus	78-83
26133397-8	2015	The DMBA/TPA skin tumourigenesis-model is highly dependent upon inflammation, and we found a greatly attenuated skin inflammatory response to DMBA/TPA-treatment in the R-Ras KO mice in the context of leukocyte infiltration and proinflammatory cytokine expression.	Tetradecanoylphorbol Acetate	9-12	related RAS viral (r-ras) oncogene	Mus musculus	168-173
26133397-8	2015	The DMBA/TPA skin tumourigenesis-model is highly dependent upon inflammation, and we found a greatly attenuated skin inflammatory response to DMBA/TPA-treatment in the R-Ras KO mice in the context of leukocyte infiltration and proinflammatory cytokine expression.	Tetradecanoylphorbol Acetate	147-150	related RAS viral (r-ras) oncogene	Mus musculus	168-173
26176694-6	2015	It was found that IR injury significantly damaged retinal function, inducing apoptosis in the retina, while NSP attenuated the loss of retinal function and significantly reduced the number of apoptotic neurons in both wild type and tPA-/- mice.	Tetradecanoylphorbol Acetate	232-235	serine (or cysteine) peptidase inhibitor, clade I, member 1	Mus musculus	108-111
26176694-7	2015	The levels of cleaved caspase-3, cleaved PARP (the substrate of caspase-3) and caspase-9 (the modulator of the caspase-3), which had increased following IR injury, were significantly inhibited by NSP in both wild type and tPA-/- mice.	Tetradecanoylphorbol Acetate	222-225	serine (or cysteine) peptidase inhibitor, clade I, member 1	Mus musculus	196-199
25109682-5	2015	The treatment of THP-1 monocytes using phorbol 12-myristate 13-acetate (PMA) was shown to initiate inflammatory responses.	Tetradecanoylphorbol Acetate	72-75	GLI family zinc finger 2	Homo sapiens	17-22
26171065-0	2015	Hispolon inhibits TPA-induced invasion by reducing MMP-9 expression through the NF-kappaB signaling pathway in MDA-MB-231 human breast cancer cells.	Tetradecanoylphorbol Acetate	18-21	nuclear factor kappa B subunit 1	Homo sapiens	80-89
26288668-1	2015	Data from randomized clinical trials have supported the safety and efficacy of intravenous tissue-type plasminogen activator (IV tPA) for acute ischemic stroke when administered within 3 hours of symptom onset, and regulatory approvals for this indication have been in place for almost 20 years.	Tetradecanoylphorbol Acetate	129-132	plasminogen activator, tissue type	Homo sapiens	91-124
26171065-7	2015	An electrophoretic mobility shift assay demonstrated that NF-kappaB DNA-binding activity was induced by TPA and inhibited by hispolon.	Tetradecanoylphorbol Acetate	104-107	nuclear factor kappa B subunit 1	Homo sapiens	58-67
26171065-9	2015	In conclusion, the results of the present study indicated that hispolon inhibited TPA-induced migration and invasion of MDA-MB-231 cells by reducing the secretion and expression of MMP-9 through the NF-kappaB signaling pathway.	Tetradecanoylphorbol Acetate	82-85	nuclear factor kappa B subunit 1	Homo sapiens	199-208
26116564-12	2015	TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	92-95
26116564-12	2015	TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	101-104
26116564-12	2015	TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	213-216
26116564-12	2015	TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors.	Tetradecanoylphorbol Acetate	126-129	mitogen-activated protein kinase 8	Homo sapiens	101-104
26116564-12	2015	TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors.	Tetradecanoylphorbol Acetate	126-129	mitogen-activated protein kinase 14	Homo sapiens	213-216
25866363-5	2015	It suppressed TPA-induced AP-1 activity through inhibiting the phosphorylation of the extracellular signal-related kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathways, and it suppressed TPA-induced inhibition of NF-kappaB nuclear translocation through IkappaB.	Tetradecanoylphorbol Acetate	14-17	mitogen-activated protein kinase 8	Homo sapiens	132-155
25866363-5	2015	It suppressed TPA-induced AP-1 activity through inhibiting the phosphorylation of the extracellular signal-related kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathways, and it suppressed TPA-induced inhibition of NF-kappaB nuclear translocation through IkappaB.	Tetradecanoylphorbol Acetate	14-17	mitogen-activated protein kinase 8	Homo sapiens	157-160
25866363-5	2015	It suppressed TPA-induced AP-1 activity through inhibiting the phosphorylation of the extracellular signal-related kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathways, and it suppressed TPA-induced inhibition of NF-kappaB nuclear translocation through IkappaB.	Tetradecanoylphorbol Acetate	200-203	mitogen-activated protein kinase 8	Homo sapiens	132-155
25866363-6	2015	Additionally, it suppressed TPA-induced activation of ERK/phosphatidylinositol 3-kinase/Akt upstream of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	28-31	AKT serine/threonine kinase 1	Homo sapiens	88-91
26062428-4	2015	The expressions of intracellular IFN-gamma and TNF-alpha were analyzed by flow cytometry after the treatment with phorbol 12-myristate 13-acetate (PMA), brefeldin A (BFA) or ionomycin in vitro.	Tetradecanoylphorbol Acetate	114-145	interferon gamma	Homo sapiens	33-42
25845759-1	2015	INTRODUCTION: Intravenous administration of tissue-type plasminogen activator (IV-tPA) remains the only approved therapy that may reverse neurological deficit in patients with acute ischemic stroke (AIS).	Tetradecanoylphorbol Acetate	82-85	plasminogen activator, tissue type	Homo sapiens	44-77
25724683-2	2015	Here, we aim to investigate the relative capacity of Toc isoforms to modify the stress-activated NfkappaB and Nrf-2 signaling pathways that regulate the expression of pro-inflammatory cytokines and antioxidant enzymes, respectively, in this well-established in vitro model of the small intestine The modulation of IFNgamma/phorbol myristate acetate (PMA)-induced inflammatory responses, determined by the expression of IL8 mRNA and protein, corresponded to the extent by which different Toc isoforms altered intracellular oxidative status in Caco-2 cells.	Tetradecanoylphorbol Acetate	350-353	nuclear factor kappa B subunit 1	Homo sapiens	97-105
25724683-2	2015	Here, we aim to investigate the relative capacity of Toc isoforms to modify the stress-activated NfkappaB and Nrf-2 signaling pathways that regulate the expression of pro-inflammatory cytokines and antioxidant enzymes, respectively, in this well-established in vitro model of the small intestine The modulation of IFNgamma/phorbol myristate acetate (PMA)-induced inflammatory responses, determined by the expression of IL8 mRNA and protein, corresponded to the extent by which different Toc isoforms altered intracellular oxidative status in Caco-2 cells.	Tetradecanoylphorbol Acetate	350-353	NFE2 like bZIP transcription factor 2	Homo sapiens	110-115
25834143-2	2015	Phorbol-12-myristate-13-acetate (PMA)-differentiated human acute monocytic leukemia cell line THP-1 was infected with H. pylori.	Tetradecanoylphorbol Acetate	0-31	GLI family zinc finger 2	Homo sapiens	94-99
25834143-2	2015	Phorbol-12-myristate-13-acetate (PMA)-differentiated human acute monocytic leukemia cell line THP-1 was infected with H. pylori.	Tetradecanoylphorbol Acetate	33-36	GLI family zinc finger 2	Homo sapiens	94-99
25933972-6	2015	Here, we investigated the precise mechanism by which LU8C-FP inhibited phorbol 12-myristate 13-acetate-induced IL-6 mRNA and protein expression.	Tetradecanoylphorbol Acetate	71-102	interleukin 6	Homo sapiens	111-115
25411080-5	2015	THP-1 monocytic cells were used in this study to elucidate the influence of zoledronate and denosumab on phorbol-12-myrisate-13-acetate (PMA)-induced macrophage differentiation and function in real-time.	Tetradecanoylphorbol Acetate	137-140	GLI family zinc finger 2	Homo sapiens	0-5
25711724-2	2015	Because protein kinase C (PKC) mimetic phorbol myristate acetate (PMA) can destabilize natriuretic peptide clearance receptor (NPR-C) mRNA and angiotensin II activates several PKC isoforms in VSMCs, we hypothesized that angiotensin II treatment decreases NPR-C mRNA stability and exerts this effect through PKC.	Tetradecanoylphorbol Acetate	39-64	angiotensinogen	Rattus norvegicus	143-157
25711724-2	2015	Because protein kinase C (PKC) mimetic phorbol myristate acetate (PMA) can destabilize natriuretic peptide clearance receptor (NPR-C) mRNA and angiotensin II activates several PKC isoforms in VSMCs, we hypothesized that angiotensin II treatment decreases NPR-C mRNA stability and exerts this effect through PKC.	Tetradecanoylphorbol Acetate	39-64	angiotensinogen	Rattus norvegicus	220-234
25711724-2	2015	Because protein kinase C (PKC) mimetic phorbol myristate acetate (PMA) can destabilize natriuretic peptide clearance receptor (NPR-C) mRNA and angiotensin II activates several PKC isoforms in VSMCs, we hypothesized that angiotensin II treatment decreases NPR-C mRNA stability and exerts this effect through PKC.	Tetradecanoylphorbol Acetate	66-69	angiotensinogen	Rattus norvegicus	143-157
25711724-2	2015	Because protein kinase C (PKC) mimetic phorbol myristate acetate (PMA) can destabilize natriuretic peptide clearance receptor (NPR-C) mRNA and angiotensin II activates several PKC isoforms in VSMCs, we hypothesized that angiotensin II treatment decreases NPR-C mRNA stability and exerts this effect through PKC.	Tetradecanoylphorbol Acetate	66-69	angiotensinogen	Rattus norvegicus	220-234
25711724-5	2015	However, this response to angiotensin II was undiminished by the PKC inhibitor chelerythrine, or by depletion of PKC by prior exposure of cells to PMA for 48 h. Inhibitors of tyrosine kinases, phospholipase C, or mitogen-activated protein kinase kinase also failed to reverse the angiotensin II effect.	Tetradecanoylphorbol Acetate	147-150	angiotensinogen	Rattus norvegicus	26-40
25625661-6	2015	Phorbol-12-myristate-13-acetate (PMA), a specific PKC activator, partially reversed the FZD-induced mitochondrial Cx43 dephosphorylation at serine 368 and mitochondrial dysfunction in the cardiomyocytes.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, epsilon	Rattus norvegicus	50-53
25625661-6	2015	Phorbol-12-myristate-13-acetate (PMA), a specific PKC activator, partially reversed the FZD-induced mitochondrial Cx43 dephosphorylation at serine 368 and mitochondrial dysfunction in the cardiomyocytes.	Tetradecanoylphorbol Acetate	0-31	gap junction protein, alpha 1	Rattus norvegicus	114-118
25625661-6	2015	Phorbol-12-myristate-13-acetate (PMA), a specific PKC activator, partially reversed the FZD-induced mitochondrial Cx43 dephosphorylation at serine 368 and mitochondrial dysfunction in the cardiomyocytes.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, epsilon	Rattus norvegicus	50-53
25625661-6	2015	Phorbol-12-myristate-13-acetate (PMA), a specific PKC activator, partially reversed the FZD-induced mitochondrial Cx43 dephosphorylation at serine 368 and mitochondrial dysfunction in the cardiomyocytes.	Tetradecanoylphorbol Acetate	33-36	gap junction protein, alpha 1	Rattus norvegicus	114-118
26062428-4	2015	The expressions of intracellular IFN-gamma and TNF-alpha were analyzed by flow cytometry after the treatment with phorbol 12-myristate 13-acetate (PMA), brefeldin A (BFA) or ionomycin in vitro.	Tetradecanoylphorbol Acetate	147-150	interferon gamma	Homo sapiens	33-42
26062428-7	2015	RESULTS: Compared with healthy controls, CHB patients presented with significantly decreased peripheral blood NK/NKT cell ratio and significantly elevated proportions of NKG2A+ NK and NKG2A+NKT cells, and after the treatment with PMA/BFA/ionomycin, IFN-gamma+ NK and IFN-gamma+ NKT cells were significantly reduced in CHB patients.	Tetradecanoylphorbol Acetate	230-233	interferon gamma	Homo sapiens	249-258
26062428-7	2015	RESULTS: Compared with healthy controls, CHB patients presented with significantly decreased peripheral blood NK/NKT cell ratio and significantly elevated proportions of NKG2A+ NK and NKG2A+NKT cells, and after the treatment with PMA/BFA/ionomycin, IFN-gamma+ NK and IFN-gamma+ NKT cells were significantly reduced in CHB patients.	Tetradecanoylphorbol Acetate	230-233	interferon gamma	Homo sapiens	267-276
25732260-5	2015	The IkappaBalpha/p65 pathway was activated by phorbol myristate acetate (PMA), a stimulator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	46-71	NFKB inhibitor alpha	Homo sapiens	4-16
25959257-7	2015	One component, 6-methyl-3,5-heptadien-2-one (MHDO), inhibited fMLF- and interleukin 8 (IL-8)-stimulated Ca(2+) flux, fMLF-induced chemotaxis, and PMA-induced ROS production in human neutrophils.	Tetradecanoylphorbol Acetate	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
25732260-5	2015	The IkappaBalpha/p65 pathway was activated by phorbol myristate acetate (PMA), a stimulator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	73-76	NFKB inhibitor alpha	Homo sapiens	4-16
25948100-5	2015	The levels of interferon-gamma (IFN-gamma) and interleukin-17 (IL-17) secreted by T cells stimulated with PMA and ionomycin were also determined by flow cytometry.	Tetradecanoylphorbol Acetate	106-109	interferon gamma	Homo sapiens	14-30
25938472-3	2015	We examined effects of seven PI polyamides (GB1101-1107) on the expression of hTGF-beta1 mRNA stimulated with phorbol 12-myristate 13-acetate (PMA) in human vascular smooth muscle cells.	Tetradecanoylphorbol Acetate	110-141	transforming growth factor beta 1	Homo sapiens	78-88
25938472-3	2015	We examined effects of seven PI polyamides (GB1101-1107) on the expression of hTGF-beta1 mRNA stimulated with phorbol 12-myristate 13-acetate (PMA) in human vascular smooth muscle cells.	Tetradecanoylphorbol Acetate	143-146	transforming growth factor beta 1	Homo sapiens	78-88
25734989-6	2015	In heterologous systems, TRPV1 S502 and S800, but not T704, are known to be involved in hypersensitivity to capsaicin after the application of phorbol myristate acetate (PMA), a PKC agonist.	Tetradecanoylphorbol Acetate	143-168	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	25-30
25748000-5	2015	The inhibition of pol lambda, a DNA repair/recombination pol, by these compounds was significantly correlated with both their suppression of lipopolysaccharide (LPS) induced tumor necrosis factor-alpha (TNF-alpha) production by mouse RAW264.7 macrophages and the reduction of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in the mouse ear.	Tetradecanoylphorbol Acetate	276-312	tumor necrosis factor	Mus musculus	203-212
25748000-5	2015	The inhibition of pol lambda, a DNA repair/recombination pol, by these compounds was significantly correlated with both their suppression of lipopolysaccharide (LPS) induced tumor necrosis factor-alpha (TNF-alpha) production by mouse RAW264.7 macrophages and the reduction of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in the mouse ear.	Tetradecanoylphorbol Acetate	314-317	tumor necrosis factor	Mus musculus	203-212
25941985-4	2015	Treatment with CPT also downregulated phorbol-12-myristate-13-acetate (PMA)- and tumor necrosis factor-alpha (TNF-alpha)-induced MMP-9 and VEGF expression by inhibiting nuclear factor-kappaB (NF-kappaB) activity.	Tetradecanoylphorbol Acetate	38-69	vascular endothelial growth factor A	Homo sapiens	139-143
25941985-4	2015	Treatment with CPT also downregulated phorbol-12-myristate-13-acetate (PMA)- and tumor necrosis factor-alpha (TNF-alpha)-induced MMP-9 and VEGF expression by inhibiting nuclear factor-kappaB (NF-kappaB) activity.	Tetradecanoylphorbol Acetate	71-74	vascular endothelial growth factor A	Homo sapiens	139-143
25941985-6	2015	We further confirmed that CPT inhibits PMA-induced MMP-9 and VEGF expression by upregulating nuclear factor-erythroid related factor-2 (Nrf2)-mediated heme oxygenase-1 (HO-1) induction.	Tetradecanoylphorbol Acetate	39-42	vascular endothelial growth factor A	Homo sapiens	61-65
25941985-6	2015	We further confirmed that CPT inhibits PMA-induced MMP-9 and VEGF expression by upregulating nuclear factor-erythroid related factor-2 (Nrf2)-mediated heme oxygenase-1 (HO-1) induction.	Tetradecanoylphorbol Acetate	39-42	NFE2 like bZIP transcription factor 2	Homo sapiens	93-134
25941985-6	2015	We further confirmed that CPT inhibits PMA-induced MMP-9 and VEGF expression by upregulating nuclear factor-erythroid related factor-2 (Nrf2)-mediated heme oxygenase-1 (HO-1) induction.	Tetradecanoylphorbol Acetate	39-42	NFE2 like bZIP transcription factor 2	Homo sapiens	136-140
25670016-5	2015	Moreover, glaucine attenuates PMA-induced IkappaBalpha degradation and nuclear translocation of NF-kappaB.	Tetradecanoylphorbol Acetate	30-33	NFKB inhibitor alpha	Homo sapiens	42-54
25670016-5	2015	Moreover, glaucine attenuates PMA-induced IkappaBalpha degradation and nuclear translocation of NF-kappaB.	Tetradecanoylphorbol Acetate	30-33	nuclear factor kappa B subunit 1	Homo sapiens	96-105
25716554-15	2015	Rosiglitazone and LCPUFAs significantly reduced PMA/calcium ionophore-induced TNF-alpha release but not degranulation of HMC-1 cells.	Tetradecanoylphorbol Acetate	48-51	tumor necrosis factor	Homo sapiens	78-87
25734989-6	2015	In heterologous systems, TRPV1 S502 and S800, but not T704, are known to be involved in hypersensitivity to capsaicin after the application of phorbol myristate acetate (PMA), a PKC agonist.	Tetradecanoylphorbol Acetate	170-173	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	25-30
25734989-7	2015	Unlike capsaicin, PMA-induced hypersensitivity to heat was attenuated in TRPV1 mutants T704A and S800A, but not in S502A.	Tetradecanoylphorbol Acetate	18-21	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	73-78
25734989-10	2015	In sensory neurons expressing mutated TRPV1, we found that alanine mutation of S800 commonly attenuates PMA-induced hypersensitivity to capsaicin, heat, and acid.	Tetradecanoylphorbol Acetate	104-107	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	38-43
25915860-0	2015	12-O-Tetradecanoylphorbol-13-Acetate Induces Up-Regulated Transcription of Variant 1 but Not Variant 2 of VIL2 in Esophageal Squamous Cell Carcinoma Cells via ERK1/2/AP-1/Sp1 Signaling.	Tetradecanoylphorbol Acetate	0-36	mitogen-activated protein kinase 3	Homo sapiens	159-165
25915860-8	2015	TPA stimulation enhanced c-Jun and Sp1 binding to the TRE via activation of the ERK1/2 pathway and increased protein levels of c-Jun, c-Fos, and Sp1, resulting in over-expression of VIL2 V1, whereas the MEK1/2 inhibitor U0126 blocked these events.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	80-86
25915860-10	2015	Taken together, these results suggest that TPA is able to induce VIL2 V1 over-expression in ESCC cells by activating MEK/ERK1/2 signaling and increasing binding of Sp1 and c-Jun to the TRE of the VIL2 V1 promoter, and that VIL2 is an important TPA-induced effector.	Tetradecanoylphorbol Acetate	43-46	mitogen-activated protein kinase kinase 7	Homo sapiens	117-120
25915860-10	2015	Taken together, these results suggest that TPA is able to induce VIL2 V1 over-expression in ESCC cells by activating MEK/ERK1/2 signaling and increasing binding of Sp1 and c-Jun to the TRE of the VIL2 V1 promoter, and that VIL2 is an important TPA-induced effector.	Tetradecanoylphorbol Acetate	43-46	mitogen-activated protein kinase 3	Homo sapiens	121-127
25908095-1	2015	Here we report that mice deficient for the proteasome activator, REGgamma, exhibit a marked resistance to TPA (12-O-tetradecanoyl-phorbol-13-acetate)-induced keratinocyte proliferation, epidermal hyperplasia and onset of papillomas compared with wild-type counterparts.	Tetradecanoylphorbol Acetate	106-109	proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)	Mus musculus	65-73
25908095-1	2015	Here we report that mice deficient for the proteasome activator, REGgamma, exhibit a marked resistance to TPA (12-O-tetradecanoyl-phorbol-13-acetate)-induced keratinocyte proliferation, epidermal hyperplasia and onset of papillomas compared with wild-type counterparts.	Tetradecanoylphorbol Acetate	111-148	proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)	Mus musculus	65-73
25908095-2	2015	Interestingly, a massive increase of REGgamma in skin tissues or cells resulting from TPA induces activation of p38 mitogen-activated protein kinase (MAPK/p38).	Tetradecanoylphorbol Acetate	86-89	proteasome activator subunit 3	Homo sapiens	37-45
25908095-2	2015	Interestingly, a massive increase of REGgamma in skin tissues or cells resulting from TPA induces activation of p38 mitogen-activated protein kinase (MAPK/p38).	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase 14	Homo sapiens	112-115
25908095-2	2015	Interestingly, a massive increase of REGgamma in skin tissues or cells resulting from TPA induces activation of p38 mitogen-activated protein kinase (MAPK/p38).	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase 14	Homo sapiens	155-158
25908095-3	2015	Blocking p38 MAPK activation prevents REGgamma elevation in HaCaT cells with TPA treatment.	Tetradecanoylphorbol Acetate	77-80	mitogen-activated protein kinase 14	Homo sapiens	9-12
25908095-3	2015	Blocking p38 MAPK activation prevents REGgamma elevation in HaCaT cells with TPA treatment.	Tetradecanoylphorbol Acetate	77-80	proteasome activator subunit 3	Homo sapiens	38-46
25908095-4	2015	AP-1, the downstream effector of MAPK/p38, directly binds to the REGgamma promoter and activates its transcription in response to TPA stimulation.	Tetradecanoylphorbol Acetate	130-133	mitogen-activated protein kinase 14	Homo sapiens	38-41
25908095-4	2015	AP-1, the downstream effector of MAPK/p38, directly binds to the REGgamma promoter and activates its transcription in response to TPA stimulation.	Tetradecanoylphorbol Acetate	130-133	proteasome activator subunit 3	Homo sapiens	65-73
25908095-6	2015	Conversely, MAPK/p38 inactivation or REGgamma deletion prevents the increase of cyclinD1 and c-Myc by TPA.	Tetradecanoylphorbol Acetate	102-105	mitogen-activated protein kinase 14	Homo sapiens	17-20
25908095-6	2015	Conversely, MAPK/p38 inactivation or REGgamma deletion prevents the increase of cyclinD1 and c-Myc by TPA.	Tetradecanoylphorbol Acetate	102-105	proteasome activator subunit 3	Homo sapiens	37-45
25906076-7	2015	Twenty-two percent of the alveolar CD3(+)CD161(+) T lymphocytes produced cytokines upon stimulation by PMA plus ionomycin, and significantly more interferon gamma (IFN-gamma) was produced compared with other cytokines (P = 0.05).	Tetradecanoylphorbol Acetate	103-106	killer cell lectin like receptor B1	Homo sapiens	41-46
25765655-4	2015	We found that increased expression of G9a along with transcription factor YY1 specifically represses UHRF1 transcription during TPA-mediated leukemia cell differentiation.	Tetradecanoylphorbol Acetate	128-131	YY1 transcription factor	Homo sapiens	74-77
25682767-0	2015	Curcumin relieves TPA-induced Th1 inflammation in K14-VEGF transgenic mice.	Tetradecanoylphorbol Acetate	18-21	negative elongation factor complex member C/D, Th1l	Mus musculus	30-33
25422283-6	2015	The innate CD8SP thymocytes express Eomes and secrete IFN-gamma after stimulation with PMA and ionomycin, and in this case their increase is not due to a bystander effect of IL-4 but cell intrinsic.	Tetradecanoylphorbol Acetate	87-90	interferon gamma	Mus musculus	54-63
25682767-3	2015	Here, we report that topical use of a curcumin gel formulation inhibited TPA-induced Th1 inflammation in K14-VEGF transgenic mice ears but not Th17 inflammation as expected.	Tetradecanoylphorbol Acetate	73-76	negative elongation factor complex member C/D, Th1l	Mus musculus	85-88
25744030-5	2015	Furthermore, megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of PDGFRbeta and NRP-1 protein expression, complex formation between PDGFRs and NRP-1, PDGFRalphabeta heterodimer complexes, and an increase in PDGF-BB-binding activity.	Tetradecanoylphorbol Acetate	80-105	thrombopoietin	Homo sapiens	52-55
25744030-5	2015	Furthermore, megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of PDGFRbeta and NRP-1 protein expression, complex formation between PDGFRs and NRP-1, PDGFRalphabeta heterodimer complexes, and an increase in PDGF-BB-binding activity.	Tetradecanoylphorbol Acetate	80-105	platelet derived growth factor receptor beta	Homo sapiens	157-166
25854428-0	2015	Poly-gamma-glutamic acid induces apoptosis via reduction of COX-2 expression in TPA-induced HT-29 human colorectal cancer cells.	Tetradecanoylphorbol Acetate	80-83	prostaglandin-endoperoxide synthase 2	Homo sapiens	60-65
25501505-6	2015	CAPE suppressed increased expression of pro-inflammatory molecules such as TNF-alpha, cyclooxygenase-2 and inducible NO synthase in TPA-stimulated skin.	Tetradecanoylphorbol Acetate	132-135	nitric oxide synthase 2	Homo sapiens	107-128
25501505-7	2015	TPA-induced phosphorylation of IkappaB and ERK was blocked by CAPE suggesting that protective effects of CAPE on skin inflammation is attributed to inhibition of NF-kappaB activation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	43-46
25682767-6	2015	We find that curcumin is capable of relieving TPA-induced inflammation by directly down-regulating IFNgamma production.	Tetradecanoylphorbol Acetate	46-49	interferon gamma	Mus musculus	99-107
25348263-0	2015	Coordinated activation of AMP-activated protein kinase, extracellular signal-regulated kinase, and autophagy regulates phorbol myristate acetate-induced differentiation of SH-SY5Y neuroblastoma cells.	Tetradecanoylphorbol Acetate	119-144	mitogen-activated protein kinase 1	Homo sapiens	56-93
25682767-7	2015	In conclusion, curcumin inhibits TPA-induced Th1 inflammation in K14-VEGF transgenic mice which has not been previously described.	Tetradecanoylphorbol Acetate	33-36	negative elongation factor complex member C/D, Th1l	Mus musculus	45-48
25620218-7	2015	TPA magnified at x50 ranges 11.9-56% for Ishak stage F5-6.	Tetradecanoylphorbol Acetate	0-3	DLEC1 cilia and flagella associated protein	Homo sapiens	53-57
25348263-1	2015	We explored the interplay between the intracellular energy sensor AMP-activated protein kinase (AMPK), extracellular signal-regulated kinase (ERK), and autophagy in phorbol myristate acetate (PMA)-induced neuronal differentiation of SH-SY5Y human neuroblastoma cells.	Tetradecanoylphorbol Acetate	192-195	mitogen-activated protein kinase 1	Homo sapiens	103-140
25348263-1	2015	We explored the interplay between the intracellular energy sensor AMP-activated protein kinase (AMPK), extracellular signal-regulated kinase (ERK), and autophagy in phorbol myristate acetate (PMA)-induced neuronal differentiation of SH-SY5Y human neuroblastoma cells.	Tetradecanoylphorbol Acetate	192-195	mitogen-activated protein kinase 1	Homo sapiens	142-145
25348263-5	2015	A selective pharmacological blockade of ERK prevented PMA-induced neuronal differentiation and autophagy induction without affecting AMPK phosphorylation.	Tetradecanoylphorbol Acetate	54-57	mitogen-activated protein kinase 1	Homo sapiens	40-43
25348263-7	2015	Therefore, PMA-induced neuronal differentiation of SH-SY5Y cells depends on a complex interplay between AMPK, ERK, and autophagy, in which the stimulatory effects of AMPK/ERK signaling are counteracted by the coinciding autophagic response.	Tetradecanoylphorbol Acetate	11-14	mitogen-activated protein kinase 1	Homo sapiens	110-113
25348263-7	2015	Therefore, PMA-induced neuronal differentiation of SH-SY5Y cells depends on a complex interplay between AMPK, ERK, and autophagy, in which the stimulatory effects of AMPK/ERK signaling are counteracted by the coinciding autophagic response.	Tetradecanoylphorbol Acetate	11-14	mitogen-activated protein kinase 1	Homo sapiens	171-174
25348263-8	2015	Phorbol myristate acetate (PMA) induces the expression of dopamine transporter, microtubule-associated protein 2, and beta-tubulin, and subsequent neuronal differentiation of SH-SY5Y neuroblastoma cells through AMP-activated protein kinase (AMPK)-dependent activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	0-25	mitogen-activated protein kinase 1	Homo sapiens	271-308
25348263-8	2015	Phorbol myristate acetate (PMA) induces the expression of dopamine transporter, microtubule-associated protein 2, and beta-tubulin, and subsequent neuronal differentiation of SH-SY5Y neuroblastoma cells through AMP-activated protein kinase (AMPK)-dependent activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	0-25	mitogen-activated protein kinase 1	Homo sapiens	310-313
25348263-8	2015	Phorbol myristate acetate (PMA) induces the expression of dopamine transporter, microtubule-associated protein 2, and beta-tubulin, and subsequent neuronal differentiation of SH-SY5Y neuroblastoma cells through AMP-activated protein kinase (AMPK)-dependent activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Homo sapiens	271-308
25348263-8	2015	Phorbol myristate acetate (PMA) induces the expression of dopamine transporter, microtubule-associated protein 2, and beta-tubulin, and subsequent neuronal differentiation of SH-SY5Y neuroblastoma cells through AMP-activated protein kinase (AMPK)-dependent activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Homo sapiens	310-313
25728938-9	2015	Notably, loss of ERalpha promoted breast cancer cell migration and invasion by inducing changes in the expression levels of certain matrix macromolecules (especially uPA, tPA, PAI-1) through the EGFR-ERK signaling pathway.	Tetradecanoylphorbol Acetate	171-174	estrogen receptor 1	Homo sapiens	17-24
25728938-9	2015	Notably, loss of ERalpha promoted breast cancer cell migration and invasion by inducing changes in the expression levels of certain matrix macromolecules (especially uPA, tPA, PAI-1) through the EGFR-ERK signaling pathway.	Tetradecanoylphorbol Acetate	171-174	epidermal growth factor receptor	Homo sapiens	195-199
25761242-3	2015	Upon application of staurosporine and to some extent after treatment with phorbol-12-myristate-13-acetate (PMA), a specific activator of protein kinase c, the caspase-3 sensitive peptide linker DEVD is cleaved.	Tetradecanoylphorbol Acetate	74-105	caspase 3	Homo sapiens	159-168
24243709-7	2015	Phorbol 12-myristate 13-acetate (PMA) and ionomycin enhanced activity of NFAT1, reduced E-cadherin and alpha-catenin protein levels, and increased protein levels of N-cadherin and Vimentin.	Tetradecanoylphorbol Acetate	0-31	cadherin 1	Homo sapiens	88-98
24243709-7	2015	Phorbol 12-myristate 13-acetate (PMA) and ionomycin enhanced activity of NFAT1, reduced E-cadherin and alpha-catenin protein levels, and increased protein levels of N-cadherin and Vimentin.	Tetradecanoylphorbol Acetate	33-36	cadherin 1	Homo sapiens	88-98
25761242-3	2015	Upon application of staurosporine and to some extent after treatment with phorbol-12-myristate-13-acetate (PMA), a specific activator of protein kinase c, the caspase-3 sensitive peptide linker DEVD is cleaved.	Tetradecanoylphorbol Acetate	107-110	caspase 3	Homo sapiens	159-168
25514083-4	2015	Treatment with PKC activator [tetradecanoyl phorbol acetate (TPA)] increased PR phosphorylation in Ser400 after 5 minutes, which in turn induced PR transcriptional activity and its subsequent degradation by the 26S proteasome 3-5 hours after treatment.	Tetradecanoylphorbol Acetate	30-59	proline rich transmembrane protein 2	Homo sapiens	15-18
25677765-10	2015	Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	146-171	interleukin 1 beta	Homo sapiens	120-132
25677765-10	2015	Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	146-171	NLR family pyrin domain containing 3	Homo sapiens	137-142
25677765-10	2015	Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	173-176	interleukin 1 beta	Homo sapiens	120-132
25677765-10	2015	Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	173-176	NLR family pyrin domain containing 3	Homo sapiens	137-142
25677765-10	2015	Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	173-176	nuclear factor kappa B subunit 1	Homo sapiens	248-257
25677765-10	2015	Furthermore, wogonoside markedly decreased production of IL-1beta, TNF-alpha and IL-6 and suppressed mRNA expression of pro-IL-1beta and NLRP3 in phorbol myristate acetate (PMA)-differentiated monocytic THP-1 cells via inhibiting the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	173-176	NLR family pyrin domain containing 3	Homo sapiens	262-267
25647520-2	2015	The target protein, von Willebrand factor (vWF), was released from human endothelial cells by adding phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	101-132	von Willebrand factor	Homo sapiens	20-41
25647520-2	2015	The target protein, von Willebrand factor (vWF), was released from human endothelial cells by adding phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	101-132	von Willebrand factor	Homo sapiens	43-46
25647520-2	2015	The target protein, von Willebrand factor (vWF), was released from human endothelial cells by adding phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	134-137	von Willebrand factor	Homo sapiens	20-41
25647520-2	2015	The target protein, von Willebrand factor (vWF), was released from human endothelial cells by adding phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	134-137	von Willebrand factor	Homo sapiens	43-46
25609252-4	2015	When HEL cells were stimulated with thrombopoietin or phorbol 12-myristate 13-acetate (PMA), alphaIIbbeta3 became activated as evidenced by binding of an activation-specific monoclonal antibody and soluble fibrinogen, adherence and spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitates.	Tetradecanoylphorbol Acetate	54-85	fibrinogen beta chain	Homo sapiens	206-216
25609252-4	2015	When HEL cells were stimulated with thrombopoietin or phorbol 12-myristate 13-acetate (PMA), alphaIIbbeta3 became activated as evidenced by binding of an activation-specific monoclonal antibody and soluble fibrinogen, adherence and spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitates.	Tetradecanoylphorbol Acetate	54-85	fibrinogen beta chain	Homo sapiens	245-255
25609252-4	2015	When HEL cells were stimulated with thrombopoietin or phorbol 12-myristate 13-acetate (PMA), alphaIIbbeta3 became activated as evidenced by binding of an activation-specific monoclonal antibody and soluble fibrinogen, adherence and spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitates.	Tetradecanoylphorbol Acetate	54-85	FERM domain containing kindlin 3	Homo sapiens	294-303
25609252-4	2015	When HEL cells were stimulated with thrombopoietin or phorbol 12-myristate 13-acetate (PMA), alphaIIbbeta3 became activated as evidenced by binding of an activation-specific monoclonal antibody and soluble fibrinogen, adherence and spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitates.	Tetradecanoylphorbol Acetate	54-85	FERM domain containing kindlin 3	Homo sapiens	352-361
25609252-4	2015	When HEL cells were stimulated with thrombopoietin or phorbol 12-myristate 13-acetate (PMA), alphaIIbbeta3 became activated as evidenced by binding of an activation-specific monoclonal antibody and soluble fibrinogen, adherence and spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitates.	Tetradecanoylphorbol Acetate	87-90	fibrinogen beta chain	Homo sapiens	206-216
25609252-4	2015	When HEL cells were stimulated with thrombopoietin or phorbol 12-myristate 13-acetate (PMA), alphaIIbbeta3 became activated as evidenced by binding of an activation-specific monoclonal antibody and soluble fibrinogen, adherence and spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitates.	Tetradecanoylphorbol Acetate	87-90	fibrinogen beta chain	Homo sapiens	245-255
25609252-4	2015	When HEL cells were stimulated with thrombopoietin or phorbol 12-myristate 13-acetate (PMA), alphaIIbbeta3 became activated as evidenced by binding of an activation-specific monoclonal antibody and soluble fibrinogen, adherence and spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitates.	Tetradecanoylphorbol Acetate	87-90	FERM domain containing kindlin 3	Homo sapiens	294-303
25609252-4	2015	When HEL cells were stimulated with thrombopoietin or phorbol 12-myristate 13-acetate (PMA), alphaIIbbeta3 became activated as evidenced by binding of an activation-specific monoclonal antibody and soluble fibrinogen, adherence and spreading on fibrinogen, colocalization of beta3 integrin and kindlin-3 in focal adhesions, and enhanced beta3 integrin-kindlin-3 association in immunoprecipitates.	Tetradecanoylphorbol Acetate	87-90	FERM domain containing kindlin 3	Homo sapiens	352-361
25514083-4	2015	Treatment with PKC activator [tetradecanoyl phorbol acetate (TPA)] increased PR phosphorylation in Ser400 after 5 minutes, which in turn induced PR transcriptional activity and its subsequent degradation by the 26S proteasome 3-5 hours after treatment.	Tetradecanoylphorbol Acetate	61-64	proline rich transmembrane protein 2	Homo sapiens	15-18
25514083-5	2015	Silencing or inhibition of PKCalpha and PKCdelta blocked PR phosphorylation and degradation induced by TPA.	Tetradecanoylphorbol Acetate	103-106	protein kinase C alpha	Homo sapiens	27-35
25514083-6	2015	Both PR isoforms were associated with PKCalpha and reached the maximum association after 5 minutes of TPA addition.	Tetradecanoylphorbol Acetate	102-105	protein kinase C alpha	Homo sapiens	38-46
25514083-7	2015	These data correlated with immunnofluorescence assays in which nuclear colocalization of PKCalpha with PR increased after TPA treatment.	Tetradecanoylphorbol Acetate	122-125	protein kinase C alpha	Homo sapiens	89-97
25514083-8	2015	We observed a 2-fold increase in cell proliferation after PKC activation with TPA that was reduced with the PR antagonist, RU486.	Tetradecanoylphorbol Acetate	78-81	proline rich transmembrane protein 2	Homo sapiens	58-61
25637530-2	2015	COX-2 was successfully visualized in mice models with phorbol myristate ester (TPA)-induced inflammation or bearing xenografted human melanoma cells by 2-[4-(aminosulfonyl)phenyl]-3-(4-methoxyphenyl)-1H-indole (C1).	Tetradecanoylphorbol Acetate	79-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
25301262-6	2015	EGFR and AKT phosphorylation was enhanced by stimulation with the ADAM17 agonist chemokine phorbol myristate acetate.	Tetradecanoylphorbol Acetate	91-116	epidermal growth factor receptor	Homo sapiens	0-4
25301262-6	2015	EGFR and AKT phosphorylation was enhanced by stimulation with the ADAM17 agonist chemokine phorbol myristate acetate.	Tetradecanoylphorbol Acetate	91-116	AKT serine/threonine kinase 1	Homo sapiens	9-12
25726525-5	2015	Using previously established cell lines that stably express IL-32theta and IL-32beta and cell lines transiently expressing IL-32theta, we observed that expression of IL-32theta inhibited phorbol 12-myristate 13-acetate (PMA)-induced monocytic differentiation in both THP-1 and HL-60 cells.	Tetradecanoylphorbol Acetate	187-218	GLI family zinc finger 2	Homo sapiens	267-272
25637530-3	2015	COX-2 protein expression in both TPA-induced inflammatory sites and human melanoma xenografts was confirmed by immunoblotting.	Tetradecanoylphorbol Acetate	33-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
25447204-5	2015	A novel FFAT (two phenylalanines in an acidic tract)-like motif was identified in ORP3; only disruption of both the FFAT-like and canonical FFAT motif abolished the phorbol-12-myristate-13-acetate (PMA) stimulated interaction of ORP3-P with VAPA.	Tetradecanoylphorbol Acetate	198-201	VAMP associated protein A	Homo sapiens	241-245
25698902-0	2015	Galangin, a novel dietary flavonoid, attenuates metastatic feature via PKC/ERK signaling pathway in TPA-treated liver cancer HepG2 cells.	Tetradecanoylphorbol Acetate	100-103	protein kinase C alpha	Homo sapiens	71-74
25679284-3	2015	We have analyzed the expression level and secretion capacity of IFNgamma from peripheral blood mononuclear cells isolated from five healthy donors and stimulated by calcium ionomycin mixed with phorbol 12-myristate 13-acetate in a non-specific manner in side-by-side testing using ELISPOT, ELISA and flow cytometry assays.	Tetradecanoylphorbol Acetate	194-225	interferon gamma	Homo sapiens	64-72
25655563-3	2015	Computer simulations based on a transcriptional regulatory model deduced from the system-wide, ladder-like transcription factor cluster structure reproduced expression pattern transitions when human THP-1 myelomonocytic leukaemia cells cease proliferation and differentiate under phorbol myristate acetate stimulation.	Tetradecanoylphorbol Acetate	280-305	GLI family zinc finger 2	Homo sapiens	199-204
25447204-5	2015	A novel FFAT (two phenylalanines in an acidic tract)-like motif was identified in ORP3; only disruption of both the FFAT-like and canonical FFAT motif abolished the phorbol-12-myristate-13-acetate (PMA) stimulated interaction of ORP3-P with VAPA.	Tetradecanoylphorbol Acetate	165-196	VAMP associated protein A	Homo sapiens	241-245
25590691-4	2015	Moreover, the active component of CKS, platyconic acid A (PA), suppressed PMA-induced MUC5AC mRNA expression (from 2.1 +- 0.2 to 1.1 +- 0.1) by inhibiting NF-kappaB activation (from 2.3 +- 0.2 to 1.2 +- 0.1) via Akt (from 3.7 +- 0.3 to 2.1 +- 0.2) (p &lt; 0.01) in A549 cells.	Tetradecanoylphorbol Acetate	74-77	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	86-92
25590691-4	2015	Moreover, the active component of CKS, platyconic acid A (PA), suppressed PMA-induced MUC5AC mRNA expression (from 2.1 +- 0.2 to 1.1 +- 0.1) by inhibiting NF-kappaB activation (from 2.3 +- 0.2 to 1.2 +- 0.1) via Akt (from 3.7 +- 0.3 to 2.1 +- 0.2) (p &lt; 0.01) in A549 cells.	Tetradecanoylphorbol Acetate	74-77	thymoma viral proto-oncogene 1	Mus musculus	212-215
25698902-0	2015	Galangin, a novel dietary flavonoid, attenuates metastatic feature via PKC/ERK signaling pathway in TPA-treated liver cancer HepG2 cells.	Tetradecanoylphorbol Acetate	100-103	mitogen-activated protein kinase 1	Homo sapiens	75-78
25698902-5	2015	We also observed through a Western blotting assay that galangin strongly inhibited the TPA-induced protein expressions of protein kinase Calpha (PKCalpha), protein kinase Cdelta (PKCdelta), phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2), the phospho-inhibitor of kappaBalpha (phospho-IkappaBalpha), c-Fos, c-Jun, and nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	87-90	protein kinase C alpha	Homo sapiens	122-154
25698902-5	2015	We also observed through a Western blotting assay that galangin strongly inhibited the TPA-induced protein expressions of protein kinase Calpha (PKCalpha), protein kinase Cdelta (PKCdelta), phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2), the phospho-inhibitor of kappaBalpha (phospho-IkappaBalpha), c-Fos, c-Jun, and nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase 1	Homo sapiens	205-246
25698902-5	2015	We also observed through a Western blotting assay that galangin strongly inhibited the TPA-induced protein expressions of protein kinase Calpha (PKCalpha), protein kinase Cdelta (PKCdelta), phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2), the phospho-inhibitor of kappaBalpha (phospho-IkappaBalpha), c-Fos, c-Jun, and nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase 3	Homo sapiens	248-254
25698902-5	2015	We also observed through a Western blotting assay that galangin strongly inhibited the TPA-induced protein expressions of protein kinase Calpha (PKCalpha), protein kinase Cdelta (PKCdelta), phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2), the phospho-inhibitor of kappaBalpha (phospho-IkappaBalpha), c-Fos, c-Jun, and nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	87-90	NFKB inhibitor alpha	Homo sapiens	303-315
25698902-5	2015	We also observed through a Western blotting assay that galangin strongly inhibited the TPA-induced protein expressions of protein kinase Calpha (PKCalpha), protein kinase Cdelta (PKCdelta), phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2), the phospho-inhibitor of kappaBalpha (phospho-IkappaBalpha), c-Fos, c-Jun, and nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	87-90	nuclear factor kappa B subunit 1	Homo sapiens	336-358
25698902-5	2015	We also observed through a Western blotting assay that galangin strongly inhibited the TPA-induced protein expressions of protein kinase Calpha (PKCalpha), protein kinase Cdelta (PKCdelta), phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2), the phospho-inhibitor of kappaBalpha (phospho-IkappaBalpha), c-Fos, c-Jun, and nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	87-90	nuclear factor kappa B subunit 1	Homo sapiens	360-369
25698902-7	2015	CONCLUSIONS: The results revealed that galangin effectively inhibited the TPA-induced invasion and migration of HepG2 cells through a protein kinase C/extracellular signal-regulated kinase (PKC/ERK) pathway.	Tetradecanoylphorbol Acetate	74-77	protein kinase C alpha	Homo sapiens	190-193
25698902-7	2015	CONCLUSIONS: The results revealed that galangin effectively inhibited the TPA-induced invasion and migration of HepG2 cells through a protein kinase C/extracellular signal-regulated kinase (PKC/ERK) pathway.	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 1	Homo sapiens	194-197
25498893-9	2015	KEY FINDINGS: A significant modulation of iNOS, CAT and Cyt P450 protein expression was recorded as a result of ELF-EMF exposure in both phorbol 12-myristate 13-acetate (PMA)-stimulated and non-stimulated cell lines.	Tetradecanoylphorbol Acetate	137-168	catalase	Homo sapiens	48-51
25533502-5	2015	Moreover, butein abolished TNF-alpha- and PMA-induced IkappaBalpha phosphorylation, which participates in NF-kappaB activation, and PMA-induced phosphorylation of c-Jun, a subunit composed of AP-1.	Tetradecanoylphorbol Acetate	42-45	NFKB inhibitor alpha	Homo sapiens	54-66
25533502-6	2015	In vitro, butein inhibited the phosphorylation of c-Jun, binding to GST beads, mediated by JNK isolated from PMA-treated cells.	Tetradecanoylphorbol Acetate	109-112	mitogen-activated protein kinase 8	Homo sapiens	91-94
25463482-6	2015	Treatment with phorbol 12-myristate 13-acetate, a commonly used inducer of megakaryopoiesis, reciprocally regulates the expressions of LPA2 and LPA3.	Tetradecanoylphorbol Acetate	15-46	lysophosphatidic acid receptor 2	Homo sapiens	135-139
25973018-12	2015	BCG induced HMGB1, IL-6, IL-10 and TNF-alpha production effectively in PMA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	71-74	interleukin 6	Homo sapiens	19-23
25973018-12	2015	BCG induced HMGB1, IL-6, IL-10 and TNF-alpha production effectively in PMA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	71-74	tumor necrosis factor	Homo sapiens	35-44
24008983-0	2015	Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway.	Tetradecanoylphorbol Acetate	13-49	F-box protein 10	Rattus norvegicus	109-115
24008983-4	2015	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced activation of a 4.2 kb WF Fbxo10 promoter region, but lower levels of activation of the homologous WKY Fbxo10 promoter region.	Tetradecanoylphorbol Acetate	0-36	F-box protein 10	Rattus norvegicus	77-83
24008983-4	2015	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced activation of a 4.2 kb WF Fbxo10 promoter region, but lower levels of activation of the homologous WKY Fbxo10 promoter region.	Tetradecanoylphorbol Acetate	0-36	F-box protein 10	Rattus norvegicus	154-160
24008983-4	2015	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced activation of a 4.2 kb WF Fbxo10 promoter region, but lower levels of activation of the homologous WKY Fbxo10 promoter region.	Tetradecanoylphorbol Acetate	38-41	F-box protein 10	Rattus norvegicus	77-83
24008983-4	2015	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced activation of a 4.2 kb WF Fbxo10 promoter region, but lower levels of activation of the homologous WKY Fbxo10 promoter region.	Tetradecanoylphorbol Acetate	38-41	F-box protein 10	Rattus norvegicus	154-160
24008983-7	2015	We also determined that activator protein 1 (AP1) family member c-Fos mediated TPA activation of the 4.2 kb WF Fbxo10 promoter.	Tetradecanoylphorbol Acetate	79-82	F-box protein 10	Homo sapiens	111-117
24008983-8	2015	TPA was shown to induce endogenous FBXO10 mRNA and FBXO10 protein in Jurkat cells, a human T cell line, with a maximal level of expression from 1.5 to 2.5 h after exposure.	Tetradecanoylphorbol Acetate	0-3	F-box protein 10	Homo sapiens	35-41
24008983-8	2015	TPA was shown to induce endogenous FBXO10 mRNA and FBXO10 protein in Jurkat cells, a human T cell line, with a maximal level of expression from 1.5 to 2.5 h after exposure.	Tetradecanoylphorbol Acetate	0-3	F-box protein 10	Homo sapiens	51-57
25451924-6	2015	Indeed, ectopic expression of miR-638 promoted phorbol 12-myristate 13-acetate- or all-trans-retinoic acid-induced differentiation of leukemic cell lines and primary AML blasts, whereas miR-638 inhibition caused an opposite phenotype.	Tetradecanoylphorbol Acetate	47-78	microRNA 638	Homo sapiens	30-37
25498893-9	2015	KEY FINDINGS: A significant modulation of iNOS, CAT and Cyt P450 protein expression was recorded as a result of ELF-EMF exposure in both phorbol 12-myristate 13-acetate (PMA)-stimulated and non-stimulated cell lines.	Tetradecanoylphorbol Acetate	170-173	catalase	Homo sapiens	48-51
25457383-6	2015	Thus, multiplex detection of cancer biomarkers (adenosine triphosphate (ATP), prostate-specific antigen (PSA), alpha-fetoprotein (AFP) and thrombin) is realized by forming specific sensing interfaces onto the cathodic poles of BPEs in different sensing channels and reported by the ECL images of the Ru(bpy)3(2+)/TPA system on the anodic poles of BPEs in detection channels.	Tetradecanoylphorbol Acetate	313-316	alpha fetoprotein	Homo sapiens	130-133
25457383-6	2015	Thus, multiplex detection of cancer biomarkers (adenosine triphosphate (ATP), prostate-specific antigen (PSA), alpha-fetoprotein (AFP) and thrombin) is realized by forming specific sensing interfaces onto the cathodic poles of BPEs in different sensing channels and reported by the ECL images of the Ru(bpy)3(2+)/TPA system on the anodic poles of BPEs in detection channels.	Tetradecanoylphorbol Acetate	313-316	coagulation factor II, thrombin	Homo sapiens	139-147
26235576-4	2015	We found that TRB1 was strongly induced by phorbol 12-myristate 13-acetate (PMA) and ionomycin in these cells.	Tetradecanoylphorbol Acetate	76-79	tribbles pseudokinase 1	Homo sapiens	14-18
25559824-11	2015	Finally, PMA + ionomycin stimulation did not induce significant alterations on MSCs phenotype but did increase indoleamine-2,3-dioxygenase (IDO), inducible costimulatory ligand (ICOSL), IL-1beta, IL-8, and TNF-alpha mRNA expression.	Tetradecanoylphorbol Acetate	9-12	interleukin 1 beta	Homo sapiens	186-194
25559824-11	2015	Finally, PMA + ionomycin stimulation did not induce significant alterations on MSCs phenotype but did increase indoleamine-2,3-dioxygenase (IDO), inducible costimulatory ligand (ICOSL), IL-1beta, IL-8, and TNF-alpha mRNA expression.	Tetradecanoylphorbol Acetate	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
25559824-11	2015	Finally, PMA + ionomycin stimulation did not induce significant alterations on MSCs phenotype but did increase indoleamine-2,3-dioxygenase (IDO), inducible costimulatory ligand (ICOSL), IL-1beta, IL-8, and TNF-alpha mRNA expression.	Tetradecanoylphorbol Acetate	9-12	tumor necrosis factor	Homo sapiens	206-215
25808435-2	2015	We propose a systematic use of serum CEA-TPA-CA15.3 tumor marker panel and criteria in order to make it an accurate tool for a postoperative breast cancer monitoring.	Tetradecanoylphorbol Acetate	41-44	CEA cell adhesion molecule 3	Homo sapiens	37-40
25808435-4	2015	RESULTS: During a mean follow-up of 3.7 years the sensitivity of the CEA-TPA-CA15.3 tumor marker panel was 93%, the specificity was 97.6% and the rate of false "warning signals" per year of follow-up was 9 per 100 patients.	Tetradecanoylphorbol Acetate	73-76	CEA cell adhesion molecule 3	Homo sapiens	69-72
26235576-4	2015	We found that TRB1 was strongly induced by phorbol 12-myristate 13-acetate (PMA) and ionomycin in these cells.	Tetradecanoylphorbol Acetate	43-74	tribbles pseudokinase 1	Homo sapiens	14-18
25461800-4	2015	The transcription and expression of the chpI, chpK, mazE, and mazF genes of Leptospira interrogans strain Lai were significantly increased during infection of phorbol 12-myristate 13-acetate-induced human THP-1 macrophages.	Tetradecanoylphorbol Acetate	159-190	GLI family zinc finger 2	Homo sapiens	205-210
24840342-3	2015	Pretreatment of RBCs with the PKC inhibitor chelerythrine, prior to the addition of phorbol-12-myristate-13-acetate (PMA), an activator of PKC, blocks the appearance of the morphology alterations and the sustained decrease in nitrates and nitrites levels induced by PMA.	Tetradecanoylphorbol Acetate	84-115	proline rich transmembrane protein 2	Homo sapiens	139-142
24840342-3	2015	Pretreatment of RBCs with the PKC inhibitor chelerythrine, prior to the addition of phorbol-12-myristate-13-acetate (PMA), an activator of PKC, blocks the appearance of the morphology alterations and the sustained decrease in nitrates and nitrites levels induced by PMA.	Tetradecanoylphorbol Acetate	117-120	proline rich transmembrane protein 2	Homo sapiens	139-142
24840342-4	2015	Inhibition of PKC also completely inhibits PMA mediated caspase-3 activation.	Tetradecanoylphorbol Acetate	43-46	proline rich transmembrane protein 2	Homo sapiens	14-17
24840342-4	2015	Inhibition of PKC also completely inhibits PMA mediated caspase-3 activation.	Tetradecanoylphorbol Acetate	43-46	caspase 3	Homo sapiens	56-65
24840342-5	2015	On the other hand, caspase 3 inhibition, lessens the PMA induced-effects on the appearance of RBC morphology alterations, although it enhances PMA-mediated effects on nitric oxide (NO) derived metabolites levels.	Tetradecanoylphorbol Acetate	53-56	caspase 3	Homo sapiens	19-28
25079913-3	2015	CCK (0.3, 100 nM) and TPA (1 muM) activated SFK and altered the activation of FAK proteins (PYK2, p125(FAK)), adaptor proteins (p130(CAS), paxillin), MAPK (p42/44, JNK, p38), Shc, PKC (PKD, MARCKS), Akt but not GSK3-beta.	Tetradecanoylphorbol Acetate	22-25	protein tyrosine kinase 2 beta	Rattus norvegicus	92-96
25079913-3	2015	CCK (0.3, 100 nM) and TPA (1 muM) activated SFK and altered the activation of FAK proteins (PYK2, p125(FAK)), adaptor proteins (p130(CAS), paxillin), MAPK (p42/44, JNK, p38), Shc, PKC (PKD, MARCKS), Akt but not GSK3-beta.	Tetradecanoylphorbol Acetate	22-25	RB transcriptional corepressor like 2	Rattus norvegicus	128-132
25079913-3	2015	CCK (0.3, 100 nM) and TPA (1 muM) activated SFK and altered the activation of FAK proteins (PYK2, p125(FAK)), adaptor proteins (p130(CAS), paxillin), MAPK (p42/44, JNK, p38), Shc, PKC (PKD, MARCKS), Akt but not GSK3-beta.	Tetradecanoylphorbol Acetate	22-25	AKT serine/threonine kinase 1	Rattus norvegicus	199-202
25332455-11	2015	In 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced keratinocytes, MMF significantly inhibited the expression of the proinflammatory cytokines, tumor necrosis factor-alpha (TNFalpha), interleukin-6, and interleukin-1alpha as well as the production of TNFalpha.	Tetradecanoylphorbol Acetate	3-39	tumor necrosis factor	Homo sapiens	146-173
25332455-11	2015	In 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced keratinocytes, MMF significantly inhibited the expression of the proinflammatory cytokines, tumor necrosis factor-alpha (TNFalpha), interleukin-6, and interleukin-1alpha as well as the production of TNFalpha.	Tetradecanoylphorbol Acetate	41-44	tumor necrosis factor	Homo sapiens	146-173
26626250-12	2015	The optimized cream showed no phase separation after 30 min centrifugation at 825 g. In the TPA-induced inflammation model, the resin formulation significantly reduced ear thickness and interleukin-1 beta levels in mouse ear tissue.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 beta	Mus musculus	186-204
25998190-4	2015	METHODS: Phorbol myristate acetate (PMA)-treated THP-1 cells were differentiated to macrophages, which were further polarized to M1 cells by lipopolysaccharide (LPS; 1 microg/ml) and interferon (IFN)-gamma (20 ng/ml) and treated with varying curcumin concentrations.	Tetradecanoylphorbol Acetate	9-34	interferon gamma	Homo sapiens	183-205
25998190-4	2015	METHODS: Phorbol myristate acetate (PMA)-treated THP-1 cells were differentiated to macrophages, which were further polarized to M1 cells by lipopolysaccharide (LPS; 1 microg/ml) and interferon (IFN)-gamma (20 ng/ml) and treated with varying curcumin concentrations.	Tetradecanoylphorbol Acetate	36-39	interferon gamma	Homo sapiens	183-205
26855970-7	2015	The LI-COR  western blot system showed that U0126 (10 muM) inhibited the phosphorylation of extracellular signal-regulated kinase-2 (p-ERK2) by phorbol myristate acetate-treated immortalized myometrial cells, U0126 (10 muM) did not alter total U-ERK2.	Tetradecanoylphorbol Acetate	144-169	latexin	Homo sapiens	54-57
26855970-7	2015	The LI-COR  western blot system showed that U0126 (10 muM) inhibited the phosphorylation of extracellular signal-regulated kinase-2 (p-ERK2) by phorbol myristate acetate-treated immortalized myometrial cells, U0126 (10 muM) did not alter total U-ERK2.	Tetradecanoylphorbol Acetate	144-169	mitogen-activated protein kinase 1	Homo sapiens	92-131
26855970-7	2015	The LI-COR  western blot system showed that U0126 (10 muM) inhibited the phosphorylation of extracellular signal-regulated kinase-2 (p-ERK2) by phorbol myristate acetate-treated immortalized myometrial cells, U0126 (10 muM) did not alter total U-ERK2.	Tetradecanoylphorbol Acetate	144-169	mitogen-activated protein kinase 1	Homo sapiens	135-139
26855970-7	2015	The LI-COR  western blot system showed that U0126 (10 muM) inhibited the phosphorylation of extracellular signal-regulated kinase-2 (p-ERK2) by phorbol myristate acetate-treated immortalized myometrial cells, U0126 (10 muM) did not alter total U-ERK2.	Tetradecanoylphorbol Acetate	144-169	latexin	Homo sapiens	219-222
26855970-7	2015	The LI-COR  western blot system showed that U0126 (10 muM) inhibited the phosphorylation of extracellular signal-regulated kinase-2 (p-ERK2) by phorbol myristate acetate-treated immortalized myometrial cells, U0126 (10 muM) did not alter total U-ERK2.	Tetradecanoylphorbol Acetate	144-169	mitogen-activated protein kinase 1	Homo sapiens	246-250
25093670-6	2015	Accordingly, TPA prevented both the A1254-induced decrease in ERK2 phosphorylation and the A1254-induced increase in Sp1, Sp3, and REST protein expression.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 1	Homo sapiens	62-66
25093670-6	2015	Accordingly, TPA prevented both the A1254-induced decrease in ERK2 phosphorylation and the A1254-induced increase in Sp1, Sp3, and REST protein expression.	Tetradecanoylphorbol Acetate	13-16	Sp3 transcription factor	Homo sapiens	122-125
26021525-8	2015	Treatment of HUVEC and EA.hy 926 cells with PKC-activating phorbol esters (phorbol-12-myristate-13-acetate, PMA or phorbol-12,13-dibutyrate) resulted in a downregulation of BDNF expression, whereas the inactive 4alpha-phorbol-12,13-didecanoate was without effect.	Tetradecanoylphorbol Acetate	75-106	proline rich transmembrane protein 2	Homo sapiens	44-47
25960826-5	2015	PMA induces neutrophil degranulation with increased extracellular myeloperoxidase and catalase activities, nitric oxide production, expression of the inflammatory genes cyclooxygenase-2, nuclear factor kappabeta, interleukin 8 and tumor necrosis factor alpha, and interleukin 6 production.	Tetradecanoylphorbol Acetate	0-3	myeloperoxidase	Homo sapiens	66-81
25960826-5	2015	PMA induces neutrophil degranulation with increased extracellular myeloperoxidase and catalase activities, nitric oxide production, expression of the inflammatory genes cyclooxygenase-2, nuclear factor kappabeta, interleukin 8 and tumor necrosis factor alpha, and interleukin 6 production.	Tetradecanoylphorbol Acetate	0-3	catalase	Homo sapiens	86-94
25960826-5	2015	PMA induces neutrophil degranulation with increased extracellular myeloperoxidase and catalase activities, nitric oxide production, expression of the inflammatory genes cyclooxygenase-2, nuclear factor kappabeta, interleukin 8 and tumor necrosis factor alpha, and interleukin 6 production.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Homo sapiens	169-258
26021525-8	2015	Treatment of HUVEC and EA.hy 926 cells with PKC-activating phorbol esters (phorbol-12-myristate-13-acetate, PMA or phorbol-12,13-dibutyrate) resulted in a downregulation of BDNF expression, whereas the inactive 4alpha-phorbol-12,13-didecanoate was without effect.	Tetradecanoylphorbol Acetate	108-111	proline rich transmembrane protein 2	Homo sapiens	44-47
26021525-10	2015	BDNF downregulation by PMA could be prevented by PKC inhibitors Go 6983 and rottlerin, but not by Go 6976.	Tetradecanoylphorbol Acetate	23-26	proline rich transmembrane protein 2	Homo sapiens	49-52
26021525-11	2015	Thus, a Go 6983/rottlerin-sensitive PKC isoform is likely to be responsible for PMA-induced BDNF downregulation.	Tetradecanoylphorbol Acetate	80-83	proline rich transmembrane protein 2	Homo sapiens	36-39
25884029-7	2015	VEGF and IL-8 correlated positively with LDH and PAI-1/tPA ratio and negatively with tPA in both loculated and nonloculated TBPE.	Tetradecanoylphorbol Acetate	55-58	vascular endothelial growth factor A	Homo sapiens	0-4
25469858-5	2015	Colony assay data further demonstrated that delphinidin 3-sambubioside inhibited 12-O- tetradecanoylphorbol-13-acetate-induced phosphorylation of MAPK/ERK kinase 1 and sequentially suppressed cell transformation.	Tetradecanoylphorbol Acetate	81-118	mitogen-activated protein kinase 3	Homo sapiens	146-150
25638774-3	2015	THP-1 cells were activated using TPA into macrophage-like cells and infected with M.abs for different time points.	Tetradecanoylphorbol Acetate	33-36	GLI family zinc finger 2	Homo sapiens	0-5
25884029-7	2015	VEGF and IL-8 correlated positively with LDH and PAI-1/tPA ratio and negatively with tPA in both loculated and nonloculated TBPE.	Tetradecanoylphorbol Acetate	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
25884029-7	2015	VEGF and IL-8 correlated positively with LDH and PAI-1/tPA ratio and negatively with tPA in both loculated and nonloculated TBPE.	Tetradecanoylphorbol Acetate	85-88	vascular endothelial growth factor A	Homo sapiens	0-4
25884029-7	2015	VEGF and IL-8 correlated positively with LDH and PAI-1/tPA ratio and negatively with tPA in both loculated and nonloculated TBPE.	Tetradecanoylphorbol Acetate	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
25489104-3	2014	Here we report that mice lacking DUSP5 show a greatly increased sensitivity to mutant Harvey-Ras (HRas(Q61L))-driven papilloma formation in the 7,12-Dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA) model of skin carcinogenesis.	Tetradecanoylphorbol Acetate	218-221	dual specificity phosphatase 5	Mus musculus	33-38
25489104-4	2014	Furthermore, mouse embryo fibroblasts (MEFs) from DUSP5(-/-) mice show increased levels of nuclear phospho-ERK immediately after TPA stimulation and fail to accumulate total ERK in the nucleus compared with DUSP5(+/+) cells.	Tetradecanoylphorbol Acetate	129-132	dual specificity phosphatase 5	Mus musculus	50-55
25489104-3	2014	Here we report that mice lacking DUSP5 show a greatly increased sensitivity to mutant Harvey-Ras (HRas(Q61L))-driven papilloma formation in the 7,12-Dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA) model of skin carcinogenesis.	Tetradecanoylphorbol Acetate	175-211	dual specificity phosphatase 5	Mus musculus	33-38
25489104-5	2014	Surprisingly, a microarray analysis reveals that only a small number of Ras/ERK-dependent TPA-responsive transcripts are up-regulated on deletion of DUSP5 in MEFs and mouse skin.	Tetradecanoylphorbol Acetate	90-93	mitogen-activated protein kinase 1	Mus musculus	76-79
25489104-5	2014	Surprisingly, a microarray analysis reveals that only a small number of Ras/ERK-dependent TPA-responsive transcripts are up-regulated on deletion of DUSP5 in MEFs and mouse skin.	Tetradecanoylphorbol Acetate	90-93	dual specificity phosphatase 5	Mus musculus	149-154
25489104-6	2014	The most up-regulated gene on DUSP5 loss encodes SerpinB2, an inhibitor of extracellular urokinase plasminogen activator and deletion of DUSP5 acts synergistically with mutant HRas(Q61L) and TPA to activate ERK-dependent SerpinB2 expression at the transcriptional level.	Tetradecanoylphorbol Acetate	191-194	dual specificity phosphatase 5	Mus musculus	30-35
25359883-2	2014	It forms a complex with both focal adhesion kinase (FAK, also known as PTK2) and Src in SCC cells derived from skin carcinomas induced by administration of the chemical DMBA followed by TPA (the DMBA/TPA model).	Tetradecanoylphorbol Acetate	186-189	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	81-84
25359883-2	2014	It forms a complex with both focal adhesion kinase (FAK, also known as PTK2) and Src in SCC cells derived from skin carcinomas induced by administration of the chemical DMBA followed by TPA (the DMBA/TPA model).	Tetradecanoylphorbol Acetate	200-203	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	81-84
25540590-5	2014	Furthermore, TPA induced a strong, rapid, but transient upregulation of CXCL8 messenger (m)RNA, whereas NaF induced a weaker, more delayed, but persistent upregulation.	Tetradecanoylphorbol Acetate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	72-77
25540590-6	2014	With respect to signaling, TPA led to an early, strong, and relatively transient extracellular signal-regulated kinase (ERK)1/2 phosphorylation, and a less marked and even more transient phosphorylation of c-jun-N-terminal kinases (JNK1/2) and p38.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Homo sapiens	81-127
25540590-0	2014	Differential NF-kappaB and MAPK activation underlies fluoride- and TPA-mediated CXCL8 (IL-8) induction in lung epithelial cells.	Tetradecanoylphorbol Acetate	67-70	nuclear factor kappa B subunit 1	Homo sapiens	13-22
25540590-6	2014	With respect to signaling, TPA led to an early, strong, and relatively transient extracellular signal-regulated kinase (ERK)1/2 phosphorylation, and a less marked and even more transient phosphorylation of c-jun-N-terminal kinases (JNK1/2) and p38.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 8	Homo sapiens	232-238
25540590-0	2014	Differential NF-kappaB and MAPK activation underlies fluoride- and TPA-mediated CXCL8 (IL-8) induction in lung epithelial cells.	Tetradecanoylphorbol Acetate	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	80-85
25540590-0	2014	Differential NF-kappaB and MAPK activation underlies fluoride- and TPA-mediated CXCL8 (IL-8) induction in lung epithelial cells.	Tetradecanoylphorbol Acetate	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
25540590-6	2014	With respect to signaling, TPA led to an early, strong, and relatively transient extracellular signal-regulated kinase (ERK)1/2 phosphorylation, and a less marked and even more transient phosphorylation of c-jun-N-terminal kinases (JNK1/2) and p38.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Homo sapiens	244-247
25540590-3	2014	To approach this, we compared the potential of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and sodium fluoride (NaF) to induce CXCL8 responses in A549 cells, with emphasis on the importance of nuclear factor kappa B (NF-kappaB)- and mitogen-activated protein kinase (MAPK) signaling.	Tetradecanoylphorbol Acetate	66-102	C-X-C motif chemokine ligand 8	Homo sapiens	146-151
25540590-3	2014	To approach this, we compared the potential of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and sodium fluoride (NaF) to induce CXCL8 responses in A549 cells, with emphasis on the importance of nuclear factor kappa B (NF-kappaB)- and mitogen-activated protein kinase (MAPK) signaling.	Tetradecanoylphorbol Acetate	104-107	C-X-C motif chemokine ligand 8	Homo sapiens	146-151
25540590-4	2014	Notably, TPA induced a greater release of CXCL8 than did NaF.	Tetradecanoylphorbol Acetate	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	42-47
25540590-9	2014	TPA also induced an early, marked phosphorylation/translocation of p65 (NF-kappaB), whereas NaF induced slower, less pronounced effects on p65.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	72-81
25540590-10	2014	The CXCL8 responses by TPA and NaF were reduced by p65-siRNA.	Tetradecanoylphorbol Acetate	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	4-9
25540590-11	2014	In conclusion, all MAPK cascades were involved in NaF-induced CXCL8 release, whereas only ERK1/2 activation was involved in response to TPA.	Tetradecanoylphorbol Acetate	136-139	mitogen-activated protein kinase 3	Homo sapiens	90-96
25520561-8	2014	Furthermore, recombinant cavin-3 significantly prevented PMA-mediated dephosphorylation of AKT, a crucial regulator in MMP-9 transcription.	Tetradecanoylphorbol Acetate	57-60	AKT serine/threonine kinase 1	Homo sapiens	91-94
25485965-3	2014	We found that ZNF300 upregulation in K562 cells coincided with megakaryocytic differentiation induced by phorbol-12-myristate-13-acetate (PMA) or erythrocytic differentiation induced by cytosine arabinoside (Ara-C), respectively.	Tetradecanoylphorbol Acetate	105-136	zinc finger protein 300	Homo sapiens	14-20
25485965-3	2014	We found that ZNF300 upregulation in K562 cells coincided with megakaryocytic differentiation induced by phorbol-12-myristate-13-acetate (PMA) or erythrocytic differentiation induced by cytosine arabinoside (Ara-C), respectively.	Tetradecanoylphorbol Acetate	138-141	zinc finger protein 300	Homo sapiens	14-20
25485965-4	2014	To further test whether ZNF300 upregulation promoted differentiation, we knocked down ZNF300 and found that ZNF300 knockdown effectively abolished PMA-induced megakaryocytic differentiation, evidenced by decreased CD61 expression.	Tetradecanoylphorbol Acetate	147-150	zinc finger protein 300	Homo sapiens	24-30
25485965-4	2014	To further test whether ZNF300 upregulation promoted differentiation, we knocked down ZNF300 and found that ZNF300 knockdown effectively abolished PMA-induced megakaryocytic differentiation, evidenced by decreased CD61 expression.	Tetradecanoylphorbol Acetate	147-150	integrin subunit beta 3	Homo sapiens	214-218
25449852-5	2014	Circulating Th1, Th2 and Th17 effector cells were identified by intracellular staining for IFN-gamma, IL-4 and IL-17, respectively, upon in vitro stimulation with PMA and calcium ionophore.	Tetradecanoylphorbol Acetate	163-166	interferon gamma	Homo sapiens	91-100
25469314-1	2014	We present a detailed characterization of fibronectin (FN) adsorption and cell adhesion on poly(ethyl acrylate) (PEA) and poly(methyl acrylate) (PMA), two polymers with very similar physicochemical properties and chemical structure, which differ in one single methyl group in the lateral chain of the polymer.	Tetradecanoylphorbol Acetate	145-148	fibronectin 1	Homo sapiens	42-53
25543044-11	2014	The extracts obviously inhibited the phosphorylation of ERK, but not JNK and p38 in PMA-stimulated NCI-H292 cells.	Tetradecanoylphorbol Acetate	84-87	mitogen-activated protein kinase 1	Homo sapiens	56-59
25449852-5	2014	Circulating Th1, Th2 and Th17 effector cells were identified by intracellular staining for IFN-gamma, IL-4 and IL-17, respectively, upon in vitro stimulation with PMA and calcium ionophore.	Tetradecanoylphorbol Acetate	163-166	interleukin 4	Homo sapiens	102-106
25231175-8	2014	Notably, the percentage of GFP-positive CD34(+) cells was increased from 7% in the absence of PMA to greater than 22% in the presence of 1 nM PMA.	Tetradecanoylphorbol Acetate	94-97	CD34 molecule	Homo sapiens	40-44
25231175-8	2014	Notably, the percentage of GFP-positive CD34(+) cells was increased from 7% in the absence of PMA to greater than 22% in the presence of 1 nM PMA.	Tetradecanoylphorbol Acetate	142-145	CD34 molecule	Homo sapiens	40-44
25339677-7	2014	We found that fMLF- and PMA-induced Rac activation were almost completely lost in mouse neutrophils lacking both DOCK2 and DOCK5.	Tetradecanoylphorbol Acetate	24-27	dedicator of cyto-kinesis 2	Mus musculus	113-118
24246091-7	2014	JaZ-30 downregulates phosphorylation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in melanoma cells stimulated by phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	132-163	zinc finger protein 346	Homo sapiens	0-3
24246091-7	2014	JaZ-30 downregulates phosphorylation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in melanoma cells stimulated by phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	132-163	mitogen-activated protein kinase 1	Homo sapiens	44-90
24246091-7	2014	JaZ-30 downregulates phosphorylation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in melanoma cells stimulated by phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	132-163	mitogen-activated protein kinase 3	Homo sapiens	92-98
25374129-7	2014	RESULTS: Pretreatment with piceatannol attenuated TPA-induced expression of COX-2 and inducible nitric oxide synthase (iNOS) in mouse skin.	Tetradecanoylphorbol Acetate	50-53	nitric oxide synthase 2, inducible	Mus musculus	86-117
25374129-7	2014	RESULTS: Pretreatment with piceatannol attenuated TPA-induced expression of COX-2 and inducible nitric oxide synthase (iNOS) in mouse skin.	Tetradecanoylphorbol Acetate	50-53	nitric oxide synthase 2, inducible	Mus musculus	119-123
25374129-11	2014	CONCLUSION: Piceatannol inhibits TPA-induced COX-2 and iNOS expression by blocking the activation of NF-kappaB and AP-1 via suppression of the IKKbeta activity and phosphorylation of MAP kinases, which provides a mechanistic basis of its anti-inflammatory effects in mouse skin.	Tetradecanoylphorbol Acetate	33-36	nitric oxide synthase 2, inducible	Mus musculus	55-59
25310083-2	2014	TPA-treated macrophages were more resistant to arsenite-induced apoptosis than monocytes, which may be associated with the induction of Bcl-2 expression.	Tetradecanoylphorbol Acetate	0-3	BCL2 apoptosis regulator	Homo sapiens	136-141
25543502-11	2014	The amount of vWF increased in cells, and vWF strings were formed on cell surface by the stimulation of phorbol-12-myristate-13-acetate(PMA).	Tetradecanoylphorbol Acetate	104-135	von Willebrand factor	Homo sapiens	14-17
25352486-1	2014	BACKGROUND AND PURPOSE: Timely administration of intravenous tissue-type plasminogen activator (IV tPA) is associated with improved outcomes for acute ischemic stroke; yet, developing processes to consistently provide prompt treatment remains a challenge.	Tetradecanoylphorbol Acetate	99-102	plasminogen activator, tissue type	Homo sapiens	61-94
25543502-11	2014	The amount of vWF increased in cells, and vWF strings were formed on cell surface by the stimulation of phorbol-12-myristate-13-acetate(PMA).	Tetradecanoylphorbol Acetate	104-135	von Willebrand factor	Homo sapiens	42-45
25543502-11	2014	The amount of vWF increased in cells, and vWF strings were formed on cell surface by the stimulation of phorbol-12-myristate-13-acetate(PMA).	Tetradecanoylphorbol Acetate	136-139	von Willebrand factor	Homo sapiens	14-17
25543502-11	2014	The amount of vWF increased in cells, and vWF strings were formed on cell surface by the stimulation of phorbol-12-myristate-13-acetate(PMA).	Tetradecanoylphorbol Acetate	136-139	von Willebrand factor	Homo sapiens	42-45
25281873-6	2014	Significantly, we have found that activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) in LNCaP prostate cancer cells down-regulates the expression of NF-YA and PRMT5 at the transcription level in a c-Fos-dependent manner.	Tetradecanoylphorbol Acetate	74-105	proline rich transmembrane protein 2	Homo sapiens	48-64
25384035-5	2014	In the present study, to assess the possible role of TACE in the pathogenesis of psoriasis, we investigated the involvement of TACE in TPA-induced psoriasis-like lesions in K5.Stat3C mice, which represent a mouse model of psoriasis.	Tetradecanoylphorbol Acetate	135-138	a disintegrin and metallopeptidase domain 17	Mus musculus	127-131
25281873-6	2014	Significantly, we have found that activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) in LNCaP prostate cancer cells down-regulates the expression of NF-YA and PRMT5 at the transcription level in a c-Fos-dependent manner.	Tetradecanoylphorbol Acetate	74-105	proline rich transmembrane protein 2	Homo sapiens	66-69
25281873-6	2014	Significantly, we have found that activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) in LNCaP prostate cancer cells down-regulates the expression of NF-YA and PRMT5 at the transcription level in a c-Fos-dependent manner.	Tetradecanoylphorbol Acetate	74-105	protein arginine methyltransferase 5	Homo sapiens	186-191
25281873-6	2014	Significantly, we have found that activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) in LNCaP prostate cancer cells down-regulates the expression of NF-YA and PRMT5 at the transcription level in a c-Fos-dependent manner.	Tetradecanoylphorbol Acetate	107-110	proline rich transmembrane protein 2	Homo sapiens	48-64
25281873-6	2014	Significantly, we have found that activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) in LNCaP prostate cancer cells down-regulates the expression of NF-YA and PRMT5 at the transcription level in a c-Fos-dependent manner.	Tetradecanoylphorbol Acetate	107-110	proline rich transmembrane protein 2	Homo sapiens	66-69
25281873-6	2014	Significantly, we have found that activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) in LNCaP prostate cancer cells down-regulates the expression of NF-YA and PRMT5 at the transcription level in a c-Fos-dependent manner.	Tetradecanoylphorbol Acetate	107-110	protein arginine methyltransferase 5	Homo sapiens	186-191
24114993-4	2014	BK5.Akt(WT) transgenic mice, where Akt1 is overexpressed in basal epidermis, are highly sensitive to TPA-induced epidermal proliferation and two-stage skin carcinogenesis.	Tetradecanoylphorbol Acetate	101-104	thymoma viral proto-oncogene 1	Mus musculus	4-7
25200870-8	2014	Treatment with a PKC inhibitor bisindolylmaleimide (BIM) I prior to PMA treatment blocked the inhibitory effect of PMA, indicating PKC activation is essential for downregulating OATP1B3 activity.	Tetradecanoylphorbol Acetate	115-118	solute carrier organic anion transporter family member 1B3	Homo sapiens	178-185
25398802-4	2014	CYP2E1 was induced by phorbol-12-myristate-13-acetate in dose-dependent manner in K562 cells as well as in hematopoietic stem cells by thrombopoietin, and ingenol 3,20-dibenzoate (IDB), respectively.	Tetradecanoylphorbol Acetate	22-53	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
24114993-4	2014	BK5.Akt(WT) transgenic mice, where Akt1 is overexpressed in basal epidermis, are highly sensitive to TPA-induced epidermal proliferation and two-stage skin carcinogenesis.	Tetradecanoylphorbol Acetate	101-104	thymoma viral proto-oncogene 1	Mus musculus	35-39
24114993-5	2014	Targeting mTORC1 with rapamycin effectively inhibited TPA-induced epidermal hyperplasia and hyperproliferation as well as tumor promotion in a dose-dependent manner in both wild-type and BK5.Akt(WT) mice.	Tetradecanoylphorbol Acetate	54-57	thymoma viral proto-oncogene 1	Mus musculus	191-194
24114993-8	2014	After 2 weeks of TPA treatment, LRCs had moved upward into the interfollicular epidermis from the bulge region of both wild-type and BK5.Akt(WT) mice.	Tetradecanoylphorbol Acetate	17-20	thymoma viral proto-oncogene 1	Mus musculus	137-140
25078038-0	2014	beta-blockade abolishes the augmented cardiac tPA release induced by transactivation of heterodimerised bradykinin receptor-2 and beta2-adrenergic receptor in vivo.	Tetradecanoylphorbol Acetate	46-49	adrenoceptor beta 2	Sus scrofa	130-155
25174454-10	2014	The siRNA studies also showed that PMA-induced MMP-9 expression is NF-kappaB-dependent.	Tetradecanoylphorbol Acetate	35-38	nuclear factor kappa B subunit 1	Homo sapiens	67-76
24895206-0	2014	Sulforaphane suppresses LPS-induced or TPA-induced downregulation of PDCD4 in RAW 264.7 cells.	Tetradecanoylphorbol Acetate	39-42	programmed cell death 4	Mus musculus	69-74
24895206-3	2014	In the present study, we show that lipopolysaccharide (LPS) or 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment reduces cellular levels of PDCD4, and this event is mediated by affecting both transcription and proteolysis in RAW 264.7 cells.	Tetradecanoylphorbol Acetate	63-99	programmed cell death 4	Mus musculus	143-148
24895206-3	2014	In the present study, we show that lipopolysaccharide (LPS) or 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment reduces cellular levels of PDCD4, and this event is mediated by affecting both transcription and proteolysis in RAW 264.7 cells.	Tetradecanoylphorbol Acetate	101-104	programmed cell death 4	Mus musculus	143-148
24895206-4	2014	We show that LPS-mediated or TPA-mediated PDCD4 downregulation is catalyzed by the activation of intracellular Akt1 or S6K1 kinases and that sulforaphane suppresses LPS-induced or TPA-induced Akt1 or S6K1 activation, thereby resulting in the attenuation of PDCD4 downregulation in RAW 264.7 cells.	Tetradecanoylphorbol Acetate	29-32	programmed cell death 4	Mus musculus	42-47
24895206-4	2014	We show that LPS-mediated or TPA-mediated PDCD4 downregulation is catalyzed by the activation of intracellular Akt1 or S6K1 kinases and that sulforaphane suppresses LPS-induced or TPA-induced Akt1 or S6K1 activation, thereby resulting in the attenuation of PDCD4 downregulation in RAW 264.7 cells.	Tetradecanoylphorbol Acetate	29-32	thymoma viral proto-oncogene 1	Mus musculus	111-115
24895206-4	2014	We show that LPS-mediated or TPA-mediated PDCD4 downregulation is catalyzed by the activation of intracellular Akt1 or S6K1 kinases and that sulforaphane suppresses LPS-induced or TPA-induced Akt1 or S6K1 activation, thereby resulting in the attenuation of PDCD4 downregulation in RAW 264.7 cells.	Tetradecanoylphorbol Acetate	29-32	thymoma viral proto-oncogene 1	Mus musculus	192-196
24895206-4	2014	We show that LPS-mediated or TPA-mediated PDCD4 downregulation is catalyzed by the activation of intracellular Akt1 or S6K1 kinases and that sulforaphane suppresses LPS-induced or TPA-induced Akt1 or S6K1 activation, thereby resulting in the attenuation of PDCD4 downregulation in RAW 264.7 cells.	Tetradecanoylphorbol Acetate	29-32	programmed cell death 4	Mus musculus	257-262
24895206-4	2014	We show that LPS-mediated or TPA-mediated PDCD4 downregulation is catalyzed by the activation of intracellular Akt1 or S6K1 kinases and that sulforaphane suppresses LPS-induced or TPA-induced Akt1 or S6K1 activation, thereby resulting in the attenuation of PDCD4 downregulation in RAW 264.7 cells.	Tetradecanoylphorbol Acetate	180-183	programmed cell death 4	Mus musculus	42-47
25225290-10	2014	PMA-induced Erk phosphorylation was reduced by ErbB2 inhibitor lapatinib, as well as by knockdown of PKC-delta but not that of PKC-alpha.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	12-15
25225290-10	2014	PMA-induced Erk phosphorylation was reduced by ErbB2 inhibitor lapatinib, as well as by knockdown of PKC-delta but not that of PKC-alpha.	Tetradecanoylphorbol Acetate	0-3	erb-b2 receptor tyrosine kinase 2	Homo sapiens	47-52
25078038-11	2014	All together, these results strongly suggest BK transactivation of beta2AR leading to enhanced beta2AR-mediated release of tPA.	Tetradecanoylphorbol Acetate	123-126	adrenoceptor beta 2	Sus scrofa	67-74
25078038-11	2014	All together, these results strongly suggest BK transactivation of beta2AR leading to enhanced beta2AR-mediated release of tPA.	Tetradecanoylphorbol Acetate	123-126	adrenoceptor beta 2	Sus scrofa	95-102
25022544-7	2014	To determine the role of PKC activation in the effects of DPP-4 inhibitors, cells were treated with PMA- which blocked the effect of DPP-4 inhibitors on NLRP3 and IL-1beta as well as TLR4 and GLP-1R.	Tetradecanoylphorbol Acetate	100-103	NLR family pyrin domain containing 3	Homo sapiens	153-158
25333975-3	2014	We investigated the underlying mechanism of EP3 expression in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages with oxidized low-density lipoprotein (oxLDL) treatment.	Tetradecanoylphorbol Acetate	62-93	prostaglandin E receptor 3	Homo sapiens	44-47
25333975-3	2014	We investigated the underlying mechanism of EP3 expression in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages with oxidized low-density lipoprotein (oxLDL) treatment.	Tetradecanoylphorbol Acetate	62-93	GLI family zinc finger 2	Homo sapiens	115-120
25333975-3	2014	We investigated the underlying mechanism of EP3 expression in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages with oxidized low-density lipoprotein (oxLDL) treatment.	Tetradecanoylphorbol Acetate	95-98	prostaglandin E receptor 3	Homo sapiens	44-47
25333975-3	2014	We investigated the underlying mechanism of EP3 expression in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages with oxidized low-density lipoprotein (oxLDL) treatment.	Tetradecanoylphorbol Acetate	95-98	GLI family zinc finger 2	Homo sapiens	115-120
25174977-5	2014	Colostral T-cells (n=13) responded to stimulation with PMA/ionomycin with a significantly higher magnitude of IL-17 (p=0.037) and similar IFN-gamma concentrations (p=0.305), while IL-4 (p=0.0002) and IL-10 (p=0.0002) production was decreased compared to PBMC.	Tetradecanoylphorbol Acetate	55-58	interleukin 4	Equus caballus	180-184
25022544-7	2014	To determine the role of PKC activation in the effects of DPP-4 inhibitors, cells were treated with PMA- which blocked the effect of DPP-4 inhibitors on NLRP3 and IL-1beta as well as TLR4 and GLP-1R.	Tetradecanoylphorbol Acetate	100-103	interleukin 1 beta	Homo sapiens	163-171
24622777-7	2014	Treatment with rutin resulted in a decrease of PMA-stimulated phosphorylation of p38, extracellular regulated kinases 1/2, and c-Jun N-terminal kinase.	Tetradecanoylphorbol Acetate	47-50	mitogen-activated protein kinase 14	Homo sapiens	81-84
25115801-3	2014	In neutrophils isolated from 20 healthy subjects, we assessed the effect of BNP on the "neutrophil burst" (O2 (-) production and MPO release) stimulated by phorbol myristate acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (fMLP), respectively.	Tetradecanoylphorbol Acetate	156-181	myeloperoxidase	Homo sapiens	129-132
25123411-5	2014	To show proof of concept, human peripheral blood mononuclear cells were stimulated with phorbol 12-myristate 13-acetate and ionomycin for a maximum of 5 h, during which their CD4 and interferon-gamma (IFN-gamma) transcript and protein levels were monitored.	Tetradecanoylphorbol Acetate	88-119	interferon gamma	Homo sapiens	201-210
25027711-6	2014	TPA-induced phosphorylation of Akt, S6 kinase (S6K), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) in mouse skin was lower in the curcumin group than in the control group.	Tetradecanoylphorbol Acetate	0-3	thymoma viral proto-oncogene 1	Mus musculus	31-34
25172501-6	2014	TPA directly caused cytotoxicity accompanied by MIF release in mouse ear epidermal keratinocytes, as well as in human keratinocytic HaCaT cells.	Tetradecanoylphorbol Acetate	0-3	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	48-51
25042796-5	2014	Human monocytic cell line THP-1 cells stimulated with phorbol-12-myristate-13-acetate (PMA) differentiated to macrophages with M2-like phenotypes.	Tetradecanoylphorbol Acetate	54-85	GLI family zinc finger 2	Homo sapiens	26-31
25042796-5	2014	Human monocytic cell line THP-1 cells stimulated with phorbol-12-myristate-13-acetate (PMA) differentiated to macrophages with M2-like phenotypes.	Tetradecanoylphorbol Acetate	87-90	GLI family zinc finger 2	Homo sapiens	26-31
25587329-7	2014	While celecoxib was able to block the 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated increase in COX-2 expression in MDA-MB-231 cells, it increased the expression of ABCG2 up to 4.27 times to the control level at mRNA level and with less intensity at protein level.	Tetradecanoylphorbol Acetate	38-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
25587329-7	2014	While celecoxib was able to block the 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated increase in COX-2 expression in MDA-MB-231 cells, it increased the expression of ABCG2 up to 4.27 times to the control level at mRNA level and with less intensity at protein level.	Tetradecanoylphorbol Acetate	76-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
25172501-10	2014	In TPA-induced skin inflammation, MIF is released from damaged keratinocytes and then triggers the chemotaxis of CD74(+)CXCR2(+) NKT cells for IFN-gamma production.	Tetradecanoylphorbol Acetate	3-6	interferon gamma	Homo sapiens	143-152
25172501-8	2014	Inhibition of MIF greatly diminished the dermal infiltration of IFN-gamma(+) NKT cells, whereas the addition of exogenous TPA and MIF to NKT cells promoted their IFN-gamma production and migration, respectively.	Tetradecanoylphorbol Acetate	122-125	interferon gamma	Homo sapiens	162-171
25051397-6	2014	The expression levels of AP-1 transcription factors were increased in HepG2 cells following induction by phorbol 12-myristate 13-acetate, but ginsenoside Rh2 suppressed this induced AP-1 expression.	Tetradecanoylphorbol Acetate	105-136	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-29
25202359-5	2014	TGFbeta1-exposed PCa cells were also co-cultured with phorbol 12-myristate 13-acetate (PMA)-treated THP-1 macrophages as a model of the tumor microenvironment.	Tetradecanoylphorbol Acetate	54-85	GLI family zinc finger 2	Homo sapiens	100-105
24742714-6	2014	However, genistein abrogated the TPA-induced transcriptional activity of NF-kappaB as determined by the luciferase reporter gene assay.	Tetradecanoylphorbol Acetate	33-36	nuclear factor kappa B subunit 1	Homo sapiens	73-82
24742714-8	2014	TPA-induced NF-kappaB phosphorylation was abolished by pharmacological inhibition of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	12-21
24742714-8	2014	TPA-induced NF-kappaB phosphorylation was abolished by pharmacological inhibition of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	85-122
24742714-8	2014	TPA-induced NF-kappaB phosphorylation was abolished by pharmacological inhibition of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	124-127
24742714-10	2014	The above findings, taken together, suggest that genistein inhibits TPA-induced COX-2 expression in MCF10A cells by blocking ERK-mediated phosphorylation of p65 and its subsequent interaction with CBP and TBP.	Tetradecanoylphorbol Acetate	68-71	prostaglandin-endoperoxide synthase 2	Homo sapiens	80-85
24742714-10	2014	The above findings, taken together, suggest that genistein inhibits TPA-induced COX-2 expression in MCF10A cells by blocking ERK-mediated phosphorylation of p65 and its subsequent interaction with CBP and TBP.	Tetradecanoylphorbol Acetate	68-71	mitogen-activated protein kinase 1	Homo sapiens	125-128
24742714-10	2014	The above findings, taken together, suggest that genistein inhibits TPA-induced COX-2 expression in MCF10A cells by blocking ERK-mediated phosphorylation of p65 and its subsequent interaction with CBP and TBP.	Tetradecanoylphorbol Acetate	68-71	CREB binding protein	Homo sapiens	197-200
24742714-3	2014	Pretreatment of cultured human breast epithelial (MCF10A) cells with genistein reduced COX-2 expression induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	115-151	prostaglandin-endoperoxide synthase 2	Homo sapiens	87-92
24742714-3	2014	Pretreatment of cultured human breast epithelial (MCF10A) cells with genistein reduced COX-2 expression induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	153-156	prostaglandin-endoperoxide synthase 2	Homo sapiens	87-92
25202359-5	2014	TGFbeta1-exposed PCa cells were also co-cultured with phorbol 12-myristate 13-acetate (PMA)-treated THP-1 macrophages as a model of the tumor microenvironment.	Tetradecanoylphorbol Acetate	87-90	GLI family zinc finger 2	Homo sapiens	100-105
25232490-2	2014	Mice lacking the pro-oncogenic transcription factor STAT3 were shown to be protected from both colitis-associated and epidermal cancers induced by the AOM/DSS and DMBA/TPA protocols, respectively.	Tetradecanoylphorbol Acetate	168-171	signal transducer and activator of transcription 3	Mus musculus	52-57
25244493-8	2014	Inhibition of ERK activation blocks phorbol myristate acetate-induced MMP-9 activity and VEGF-A secretion in vitro.	Tetradecanoylphorbol Acetate	36-61	mitogen-activated protein kinase 1	Homo sapiens	14-17
25244493-8	2014	Inhibition of ERK activation blocks phorbol myristate acetate-induced MMP-9 activity and VEGF-A secretion in vitro.	Tetradecanoylphorbol Acetate	36-61	vascular endothelial growth factor A	Homo sapiens	89-95
25241044-8	2014	Furthermore, curcumin reversed PMA stimulated PKC activation and suppressed the chronic activation of AMPK, which in turn reduced the expression of MMP-9, MMP-13 and EMMPRIN.	Tetradecanoylphorbol Acetate	31-34	proline rich transmembrane protein 2	Homo sapiens	46-49
25241044-8	2014	Furthermore, curcumin reversed PMA stimulated PKC activation and suppressed the chronic activation of AMPK, which in turn reduced the expression of MMP-9, MMP-13 and EMMPRIN.	Tetradecanoylphorbol Acetate	31-34	matrix metallopeptidase 13	Homo sapiens	155-161
24877691-6	2014	ZO-NP was found to inhibit the productions and mRNA expressions of inflammatory cytokines such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha on the phorbol 12-myristate 13-acetate plus A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells.	Tetradecanoylphorbol Acetate	167-198	interleukin 6	Homo sapiens	122-159
25038525-7	2014	TPA enhanced the frequency and size of lumen formation and correlated with a robust increase in phosphorylation of p42/p44 Erk kinase, while S1P and SDF did not.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	123-126
24996056-2	2014	Here, we confirmed that IL-32theta, a new isoform of IL-32, decreased the phorbol 12-myristate 13-acetate (PMA)-induced IL-1beta expression in THP-1 human myelomonocyte.	Tetradecanoylphorbol Acetate	74-105	interleukin 1 beta	Homo sapiens	120-128
24747121-3	2014	Since the aberrant expression of cyclooxygenase-2 (COX-2) links inflammation and cancer, the present study was aimed to elucidate the mechanisms by which sulforaphane modulates COX-2 overexpression in human mammary epithelial (MCF-10A) cells stimulated with a prototypic tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	286-322	prostaglandin-endoperoxide synthase 2	Homo sapiens	33-49
24747121-3	2014	Since the aberrant expression of cyclooxygenase-2 (COX-2) links inflammation and cancer, the present study was aimed to elucidate the mechanisms by which sulforaphane modulates COX-2 overexpression in human mammary epithelial (MCF-10A) cells stimulated with a prototypic tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	286-322	prostaglandin-endoperoxide synthase 2	Homo sapiens	51-56
25200149-2	2014	METHODS: The macrophage model was established through incubating the human monocyte line (THP-1 cells) with phorbol-12-myristate 13-acetate (PMA) (10 ng/mL) for 48 hours.	Tetradecanoylphorbol Acetate	108-139	GLI family zinc finger 2	Homo sapiens	90-95
25200149-2	2014	METHODS: The macrophage model was established through incubating the human monocyte line (THP-1 cells) with phorbol-12-myristate 13-acetate (PMA) (10 ng/mL) for 48 hours.	Tetradecanoylphorbol Acetate	141-144	GLI family zinc finger 2	Homo sapiens	90-95
24747121-3	2014	Since the aberrant expression of cyclooxygenase-2 (COX-2) links inflammation and cancer, the present study was aimed to elucidate the mechanisms by which sulforaphane modulates COX-2 overexpression in human mammary epithelial (MCF-10A) cells stimulated with a prototypic tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	324-327	prostaglandin-endoperoxide synthase 2	Homo sapiens	33-49
24747121-3	2014	Since the aberrant expression of cyclooxygenase-2 (COX-2) links inflammation and cancer, the present study was aimed to elucidate the mechanisms by which sulforaphane modulates COX-2 overexpression in human mammary epithelial (MCF-10A) cells stimulated with a prototypic tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	324-327	prostaglandin-endoperoxide synthase 2	Homo sapiens	51-56
24747121-4	2014	Treatment of MCF-10A cells with sulforaphane significantly inhibited TPA-induced expression of COX-2 protein and its mRNA transcript.	Tetradecanoylphorbol Acetate	69-72	prostaglandin-endoperoxide synthase 2	Homo sapiens	95-100
24747121-5	2014	Transient transfection of cells with deletion mutant constructs of COX-2 promoter revealed that the transcription factor nuclear factor-kappaB (NF-kappaB) plays a key role in TPA-induced COX-2 expression in MCF-10A cells.	Tetradecanoylphorbol Acetate	175-178	prostaglandin-endoperoxide synthase 2	Homo sapiens	67-72
24747121-5	2014	Transient transfection of cells with deletion mutant constructs of COX-2 promoter revealed that the transcription factor nuclear factor-kappaB (NF-kappaB) plays a key role in TPA-induced COX-2 expression in MCF-10A cells.	Tetradecanoylphorbol Acetate	175-178	nuclear factor kappa B subunit 1	Homo sapiens	121-142
24747121-5	2014	Transient transfection of cells with deletion mutant constructs of COX-2 promoter revealed that the transcription factor nuclear factor-kappaB (NF-kappaB) plays a key role in TPA-induced COX-2 expression in MCF-10A cells.	Tetradecanoylphorbol Acetate	175-178	nuclear factor kappa B subunit 1	Homo sapiens	144-153
24747121-5	2014	Transient transfection of cells with deletion mutant constructs of COX-2 promoter revealed that the transcription factor nuclear factor-kappaB (NF-kappaB) plays a key role in TPA-induced COX-2 expression in MCF-10A cells.	Tetradecanoylphorbol Acetate	175-178	prostaglandin-endoperoxide synthase 2	Homo sapiens	187-192
24747121-6	2014	Pretreatment with sulforaphane significantly attenuated nuclear localization, DNA binding and the transcriptional activity of NF-kappaB through inhibition of phosphorylation and subsequent degradation of IkappaBalpha in MCF-10A cells stimulated with TPA.	Tetradecanoylphorbol Acetate	250-253	nuclear factor kappa B subunit 1	Homo sapiens	126-135
24747121-6	2014	Pretreatment with sulforaphane significantly attenuated nuclear localization, DNA binding and the transcriptional activity of NF-kappaB through inhibition of phosphorylation and subsequent degradation of IkappaBalpha in MCF-10A cells stimulated with TPA.	Tetradecanoylphorbol Acetate	250-253	NFKB inhibitor alpha	Homo sapiens	204-216
24747121-7	2014	Sulforaphane also attenuated TPA-induced activation of IkappaB kinases (IKK), NF-kappaB-activating kinase (NAK) and extracellular signal-regulated kinase-1/2 (ERK1/2).	Tetradecanoylphorbol Acetate	29-32	mitogen-activated protein kinase 1	Homo sapiens	116-157
24747121-7	2014	Sulforaphane also attenuated TPA-induced activation of IkappaB kinases (IKK), NF-kappaB-activating kinase (NAK) and extracellular signal-regulated kinase-1/2 (ERK1/2).	Tetradecanoylphorbol Acetate	29-32	mitogen-activated protein kinase 3	Homo sapiens	159-165
24747121-8	2014	Pharmacological inhibition of IKK or transient transfection of cells with dominant-negative mutant forms of this kinase abrogated TPA-induced NF-kappaB activation and COX-2 expression.	Tetradecanoylphorbol Acetate	130-133	nuclear factor kappa B subunit 1	Homo sapiens	142-151
24747121-8	2014	Pharmacological inhibition of IKK or transient transfection of cells with dominant-negative mutant forms of this kinase abrogated TPA-induced NF-kappaB activation and COX-2 expression.	Tetradecanoylphorbol Acetate	130-133	prostaglandin-endoperoxide synthase 2	Homo sapiens	167-172
24747121-10	2014	Taken together, sulforaphane inhibits TPA-induced NF-kappaB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKalpha and NAK-IKKbeta.	Tetradecanoylphorbol Acetate	38-41	nuclear factor kappa B subunit 1	Homo sapiens	50-59
24747121-10	2014	Taken together, sulforaphane inhibits TPA-induced NF-kappaB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKalpha and NAK-IKKbeta.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase 3	Homo sapiens	165-171
25157570-7	2014	Additionally, it complemented the inhibitors of either ERK1/2 or JNK MAP kinase in bringing down the PMA-induced cell proliferation in SW-480 cells.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase 8	Homo sapiens	65-68
25157570-6	2014	Mechanistically, [6]-gingerol down-regulated Phorbol Myristate Acetate (PMA) induced phosphorylation of ERK1/2 and JNK MAP kinases and activation of AP-1 transcription factor, but had only little effects on phosphorylation of p38 MAP kinase and activation of NF-kappa B.	Tetradecanoylphorbol Acetate	45-70	nuclear factor kappa B subunit 1	Homo sapiens	259-269
25157570-6	2014	Mechanistically, [6]-gingerol down-regulated Phorbol Myristate Acetate (PMA) induced phosphorylation of ERK1/2 and JNK MAP kinases and activation of AP-1 transcription factor, but had only little effects on phosphorylation of p38 MAP kinase and activation of NF-kappa B.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 3	Homo sapiens	104-110
25157570-6	2014	Mechanistically, [6]-gingerol down-regulated Phorbol Myristate Acetate (PMA) induced phosphorylation of ERK1/2 and JNK MAP kinases and activation of AP-1 transcription factor, but had only little effects on phosphorylation of p38 MAP kinase and activation of NF-kappa B.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 8	Homo sapiens	115-118
25157570-6	2014	Mechanistically, [6]-gingerol down-regulated Phorbol Myristate Acetate (PMA) induced phosphorylation of ERK1/2 and JNK MAP kinases and activation of AP-1 transcription factor, but had only little effects on phosphorylation of p38 MAP kinase and activation of NF-kappa B.	Tetradecanoylphorbol Acetate	72-75	nuclear factor kappa B subunit 1	Homo sapiens	259-269
25157570-7	2014	Additionally, it complemented the inhibitors of either ERK1/2 or JNK MAP kinase in bringing down the PMA-induced cell proliferation in SW-480 cells.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase 3	Homo sapiens	55-61
25157570-6	2014	Mechanistically, [6]-gingerol down-regulated Phorbol Myristate Acetate (PMA) induced phosphorylation of ERK1/2 and JNK MAP kinases and activation of AP-1 transcription factor, but had only little effects on phosphorylation of p38 MAP kinase and activation of NF-kappa B.	Tetradecanoylphorbol Acetate	45-70	mitogen-activated protein kinase 3	Homo sapiens	104-110
25157570-6	2014	Mechanistically, [6]-gingerol down-regulated Phorbol Myristate Acetate (PMA) induced phosphorylation of ERK1/2 and JNK MAP kinases and activation of AP-1 transcription factor, but had only little effects on phosphorylation of p38 MAP kinase and activation of NF-kappa B.	Tetradecanoylphorbol Acetate	45-70	mitogen-activated protein kinase 8	Homo sapiens	115-118
24996056-2	2014	Here, we confirmed that IL-32theta, a new isoform of IL-32, decreased the phorbol 12-myristate 13-acetate (PMA)-induced IL-1beta expression in THP-1 human myelomonocyte.	Tetradecanoylphorbol Acetate	107-110	interleukin 1 beta	Homo sapiens	120-128
24951586-4	2014	First, silencing ASM with siRNA abrogated IL-6 production in response to the tumor promoter, 4beta-phorbol 12-myristate 13-acetate (PMA), in MCF-7 cells, in distinction to acid beta-glucosidase 1 and acid ceramidase, suggesting specialization of the pathways.	Tetradecanoylphorbol Acetate	93-130	sphingomyelin phosphodiesterase 1	Homo sapiens	17-20
25133483-5	2014	We show that ectopic IkappaB kinase e (IKKe) expression in these cells partly restored MMP-3 expression levels and also sensitized MMP-3 transcription to induction by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	167-198	matrix metallopeptidase 3	Homo sapiens	131-136
24960060-6	2014	In addition, analysis of p53 target genes in TPA-pre-treated TK6 cells revealed a significant modulation of UVC-induced gene expression that supported a shift toward a pro-apoptotic phenotype.	Tetradecanoylphorbol Acetate	45-48	tumor protein p53	Homo sapiens	25-28
24951586-4	2014	First, silencing ASM with siRNA abrogated IL-6 production in response to the tumor promoter, 4beta-phorbol 12-myristate 13-acetate (PMA), in MCF-7 cells, in distinction to acid beta-glucosidase 1 and acid ceramidase, suggesting specialization of the pathways.	Tetradecanoylphorbol Acetate	132-135	sphingomyelin phosphodiesterase 1	Homo sapiens	17-20
24951586-4	2014	First, silencing ASM with siRNA abrogated IL-6 production in response to the tumor promoter, 4beta-phorbol 12-myristate 13-acetate (PMA), in MCF-7 cells, in distinction to acid beta-glucosidase 1 and acid ceramidase, suggesting specialization of the pathways.	Tetradecanoylphorbol Acetate	132-135	interleukin 6	Homo sapiens	42-46
24951586-4	2014	First, silencing ASM with siRNA abrogated IL-6 production in response to the tumor promoter, 4beta-phorbol 12-myristate 13-acetate (PMA), in MCF-7 cells, in distinction to acid beta-glucosidase 1 and acid ceramidase, suggesting specialization of the pathways.	Tetradecanoylphorbol Acetate	93-130	interleukin 6	Homo sapiens	42-46
24779584-5	2014	Expression of IL-8 receptors (CXCR1 and CXCR2) and the LPS receptor TLR4 was similar on neutrophils from young and old subjects, and neutrophils challenged with phorbol-12-myristate-13-acetate (PMA) showed no age-associated differences in ROS or NET production.	Tetradecanoylphorbol Acetate	194-197	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
24946851-0	2014	Chemopreventive effect of a novel, selective TACE inhibitor on DMBA- and TPA-induced skin carcinogenesis.	Tetradecanoylphorbol Acetate	73-76	a disintegrin and metallopeptidase domain 17	Mus musculus	45-49
24956528-8	2014	Niacin (0.25-0.5 mM) decreased PMA-induced MPO activity (cellular and released in the media).	Tetradecanoylphorbol Acetate	31-34	myeloperoxidase	Homo sapiens	43-46
24946851-9	2014	A dose-dependent suppression in TPA-mediated TNF-alpha, IL-6, IFN-gamma, IL-17 and PGE2 levels which was associated with a decrease in infiltration of inflammatory cells was also observed with the treatment.	Tetradecanoylphorbol Acetate	32-35	tumor necrosis factor	Mus musculus	45-54
24946851-9	2014	A dose-dependent suppression in TPA-mediated TNF-alpha, IL-6, IFN-gamma, IL-17 and PGE2 levels which was associated with a decrease in infiltration of inflammatory cells was also observed with the treatment.	Tetradecanoylphorbol Acetate	32-35	interleukin 6	Mus musculus	56-60
24946851-9	2014	A dose-dependent suppression in TPA-mediated TNF-alpha, IL-6, IFN-gamma, IL-17 and PGE2 levels which was associated with a decrease in infiltration of inflammatory cells was also observed with the treatment.	Tetradecanoylphorbol Acetate	32-35	interferon gamma	Mus musculus	62-71
24946851-11	2014	DISCUSSION AND CONCLUSION: These findings suggest that selective blockade of TACE suppresses TPA-induced epidermal hyperplasia, inflammatory cell infiltration and cytokine level.	Tetradecanoylphorbol Acetate	93-96	a disintegrin and metallopeptidase domain 17	Mus musculus	77-81
24947514-4	2014	We previously demonstrated that YB-1 protein is transiently up-regulated during monocyte/macrophage differentiation evidenced in monocytic cells (THP-1 cells) that were differentiated using phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	190-215	Y-box binding protein 1	Homo sapiens	32-36
24780839-0	2014	PMA induces androgen receptor downregulation and cellular apoptosis in prostate cancer cells.	Tetradecanoylphorbol Acetate	0-3	androgen receptor	Homo sapiens	12-29
24780839-1	2014	Phorbol 12-myristate 13-acetate (PMA) induces cellular apoptosis in prostate cancer cells, the growth of which is governed by androgen/androgen receptor (AR) signaling, but the mechanism by which PMA exerts this effect remains unknown.	Tetradecanoylphorbol Acetate	0-31	androgen receptor	Homo sapiens	135-152
24780839-1	2014	Phorbol 12-myristate 13-acetate (PMA) induces cellular apoptosis in prostate cancer cells, the growth of which is governed by androgen/androgen receptor (AR) signaling, but the mechanism by which PMA exerts this effect remains unknown.	Tetradecanoylphorbol Acetate	33-36	androgen receptor	Homo sapiens	135-152
24780839-8	2014	In conclusion, PMA exerted its anti-cancer effects via the activation of pro-apoptotic JNK/p53 and inhibition of pro-proliferative E2F1/AR in prostate cancer cells including CRPC cells.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	87-90
24859472-4	2014	The results revealed that 12-O-tetradecanoylphorbol-13-acetate-induced increases in COX-2 and MMP-9 expression levels were reversed by proton beam irradiation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	26-62	prostaglandin-endoperoxide synthase 2	Homo sapiens	84-89
25000305-0	2014	Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-kappaB activation through MAPK signaling pathways in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	23-26	nuclear factor kappa B subunit 1	Homo sapiens	68-77
25000305-7	2014	These results suggest that delphinidin is a potential antimetastatic agent that suppresses PMA-induced cancer cell invasion through the specific inhibition of NF-kappaB-dependent MMP-9 gene expression.	Tetradecanoylphorbol Acetate	91-94	nuclear factor kappa B subunit 1	Homo sapiens	159-168
24947514-4	2014	We previously demonstrated that YB-1 protein is transiently up-regulated during monocyte/macrophage differentiation evidenced in monocytic cells (THP-1 cells) that were differentiated using phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	217-220	Y-box binding protein 1	Homo sapiens	32-36
24947514-5	2014	Here we provide evidence that YB-1 phosphorylation, specifically at its serine residue 102 (Ser-102), increases early on in THP-1 cells following PMA treatment as well as in differentiated primary human monocytes.	Tetradecanoylphorbol Acetate	146-149	Y-box binding protein 1	Homo sapiens	30-34
24969624-6	2014	In human monocytic THP-1 cells treated with phorbol-12-myristate-13-acetate to induce differentiation to macrophages, treatment with lipopolysaccharide caused down-regulation of peptide YY mRNA levels.	Tetradecanoylphorbol Acetate	44-75	peptide YY	Homo sapiens	178-188
24831767-7	2014	RESULTS: Monocytes derived from peripheral blood mononuclear cells cultured in interleukin-4 and granulocyte macrophage colony stimulating factor differentiated into immature dendritic cells that phenotypically differentiated into mature dendritic cells in response to conditioned media from phorbol myristate acetate-activated THP-1 monocytes.	Tetradecanoylphorbol Acetate	292-317	interleukin 4	Homo sapiens	79-92
25084273-9	2014	Three genes appeared to be sensitive to therapy and returned to "healthy" condition: phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1), hydrogen voltage-gated channel 1 (HVCN1), and beta-arrestin 1 (ARRB1).	Tetradecanoylphorbol Acetate	85-116	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	136-142
25158571-4	2014	To explore the importance of differentiation the monocytic cell line THP-1 was pre-treated with PMA and IFNy.	Tetradecanoylphorbol Acetate	96-99	GLI family zinc finger 2	Homo sapiens	69-74
24829506-2	2014	In wild-type (wt-)BGT1-expressing oocytes, GABA-mediated currents were diminished by preincubation of oocytes with 100 nM PMA or 5 muM dioctanoyl-sn-glycerol, activators of PKC, whereas the application of staurosporine before the application of dioctanoyl-sn-glycerol restored the response to GABA.	Tetradecanoylphorbol Acetate	122-125	solute carrier family 6 member 12	Canis lupus familiaris	18-22
24850301-9	2014	PMA-induced phosphorylation of ERK1/2 signal was also suppressed by blocking CD44.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	31-37
25143809-5	2014	We show that TPA-induced Akt1 directly phosphorylates HP1gamma, abrogates its suppressive function and increases the interaction between histone H3 and 14-3-3epsilon.	Tetradecanoylphorbol Acetate	13-16	AKT serine/threonine kinase 1	Homo sapiens	25-29
24801891-5	2014	Phorbol myristate acetate-stimulated whole blood interleukin (IL)-4, IL-5, IL-10, IL-12, IL-13, IL-17A, IL-17F, IL-22, and interferon-gamma secretory responses were analyzed for associations comparing participants with allergic vs nonallergic asthma phenotypes with those without asthma.	Tetradecanoylphorbol Acetate	0-25	interleukin 13	Homo sapiens	89-94
24801891-5	2014	Phorbol myristate acetate-stimulated whole blood interleukin (IL)-4, IL-5, IL-10, IL-12, IL-13, IL-17A, IL-17F, IL-22, and interferon-gamma secretory responses were analyzed for associations comparing participants with allergic vs nonallergic asthma phenotypes with those without asthma.	Tetradecanoylphorbol Acetate	0-25	interferon gamma	Homo sapiens	123-139
24403179-2	2014	In this paper, the anti-inflammatory effects of M. sylvestris alcoholic extracts were evaluated by measuring the pro-inflammatory mediators PGE2 and PGD2 in desferrioxamine-stimulated phorbol 12-myristate 13-acetate-differentiated U937 cells.	Tetradecanoylphorbol Acetate	184-215	prostaglandin D2 synthase	Homo sapiens	149-153
24952939-6	2014	Therefore, p65-dependent NF-kappaB signalling in keratinocytes promotes DMBA-/TPA-induced skin carcinogenesis by protecting keratinocytes from DNA damage-induced death and facilitating the establishment of a tumour-nurturing proinflammatory microenvironment.	Tetradecanoylphorbol Acetate	78-81	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	25-34
24637302-0	2014	PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism.	Tetradecanoylphorbol Acetate	0-3	integrin subunit beta 3	Homo sapiens	33-37
24464434-0	2014	Roles of PKC Isoforms in PMA-Induced Modulation of the hERG Channel (Kv11.1).	Tetradecanoylphorbol Acetate	25-28	protein kinase C alpha	Homo sapiens	9-12
24464434-0	2014	Roles of PKC Isoforms in PMA-Induced Modulation of the hERG Channel (Kv11.1).	Tetradecanoylphorbol Acetate	25-28	ETS transcription factor ERG	Homo sapiens	55-59
24496235-6	2014	EGF and 12-O-tetradecanoylphorbol-13-acetate induce Stat3 mitochondrial translocation mediated through the phosphorylation of Stat3 at Ser727.	Tetradecanoylphorbol Acetate	8-44	signal transducer and activator of transcription 3	Homo sapiens	52-57
24496235-6	2014	EGF and 12-O-tetradecanoylphorbol-13-acetate induce Stat3 mitochondrial translocation mediated through the phosphorylation of Stat3 at Ser727.	Tetradecanoylphorbol Acetate	8-44	signal transducer and activator of transcription 3	Homo sapiens	126-131
24840330-13	2014	Taken together, our findings reveal that Slit2 promotes DMBA/TPA-induced skin tumorigenesis by increasing cell proliferation, microvessel density, and invasive behavior of cutaneous squamous cell carcinoma, along with loss of basement membrane, by upregulation of MMP2 expression.	Tetradecanoylphorbol Acetate	61-64	slit guidance ligand 2	Mus musculus	41-46
23564320-11	2014	We have found that, H3-Thr45 phosphorylation correlates to S6K activation in response to mitogens and TPA-induced cell differentiation of leukaemic cell lines U937, HL60 and THP1.	Tetradecanoylphorbol Acetate	102-105	GLI family zinc finger 2	Homo sapiens	174-178
24916153-11	2014	Stimulation of PKC directly with PMA provoked strong COX-2 expression.	Tetradecanoylphorbol Acetate	33-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	53-58
24522860-7	2014	Furthermore, M3 mAChR-mediated NF-kappaB activation and IL-8 expression were simultaneously attenuated by the PKC inhibitor calphostin C, whereas PMA, a PKC activator, mimicked the effects of carbachol, inducing IL-8 expression.	Tetradecanoylphorbol Acetate	146-149	proline rich transmembrane protein 2	Homo sapiens	153-156
24486723-9	2014	Moreover, MED inhibited TPA-induced NF-kappaB activation via blocking phosphorylation and degradation of IkappaBalpha and phosphorylation of IkappaB kinase (IKK).	Tetradecanoylphorbol Acetate	24-27	NFKB inhibitor alpha	Homo sapiens	105-117
24930874-4	2014	12-O-tetradecanoylphorbol-13-acetate (TPA), lysophosphatidic acid (LPA) as a ligand for seventransmembrane G protein coupled receptors (GPCR) and sorbitol as stress induced shedding of HB-EGF mediated protein kinase C (PKC)-delta, mitogen-activated protein kinase (MAPK) and p38MAPK, respectively.	Tetradecanoylphorbol Acetate	0-36	proheparin-binding EGF-like growth factor	Chlorocebus sabaeus	185-191
24696491-6	2014	Here we further report that an RNA interference-based knockdown of KAP1 in KSHV-infected primary effusion lymphoma (PEL) cells disrupted viral episome stability and abrogated sub-G1/G1 arrest of the cell cycle while increasing the efficiency of KSHV lytic reactivation by hypoxia or using the chemical 12-O-tetradecanoylphorbol-13-acetate (TPA) or sodium butyrate (NaB).	Tetradecanoylphorbol Acetate	302-338	tripartite motif containing 28	Homo sapiens	67-71
24696491-6	2014	Here we further report that an RNA interference-based knockdown of KAP1 in KSHV-infected primary effusion lymphoma (PEL) cells disrupted viral episome stability and abrogated sub-G1/G1 arrest of the cell cycle while increasing the efficiency of KSHV lytic reactivation by hypoxia or using the chemical 12-O-tetradecanoylphorbol-13-acetate (TPA) or sodium butyrate (NaB).	Tetradecanoylphorbol Acetate	340-343	tripartite motif containing 28	Homo sapiens	67-71
24732112-5	2014	Furthermore, the effect of the extracts, EUG and IMT, was studied on phorbol-12-myristate-13-acetate (PMA) induced monocyte to macrophage differentiation and gene expression of CD14, TLR2 and TLR4.	Tetradecanoylphorbol Acetate	102-105	toll like receptor 2	Homo sapiens	183-187
24936444-4	2014	Treatments with hyperglycaemia (25 mM) or phorbol myristate acetate (PMA, a protein kinase C activator, 100 nM) significantly increased NADPH oxidase activity, O2 ( -) generation, proapoptotic protein Bax expression, TUNEL-positive staining and caspase-3/7 activities.	Tetradecanoylphorbol Acetate	69-72	caspase 3	Homo sapiens	245-254
24859347-0	2014	The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin.	Tetradecanoylphorbol Acetate	121-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
23852815-10	2014	DES, FA, and RU24858, but not RU24782, were also able to reverse TPA-induced increases in the mRNA levels of COX-2 and iNOS.	Tetradecanoylphorbol Acetate	65-68	nitric oxide synthase 2, inducible	Mus musculus	119-123
24936444-4	2014	Treatments with hyperglycaemia (25 mM) or phorbol myristate acetate (PMA, a protein kinase C activator, 100 nM) significantly increased NADPH oxidase activity, O2 ( -) generation, proapoptotic protein Bax expression, TUNEL-positive staining and caspase-3/7 activities.	Tetradecanoylphorbol Acetate	42-67	BCL2 associated X, apoptosis regulator	Homo sapiens	201-204
24936444-4	2014	Treatments with hyperglycaemia (25 mM) or phorbol myristate acetate (PMA, a protein kinase C activator, 100 nM) significantly increased NADPH oxidase activity, O2 ( -) generation, proapoptotic protein Bax expression, TUNEL-positive staining and caspase-3/7 activities.	Tetradecanoylphorbol Acetate	42-67	caspase 3	Homo sapiens	245-254
24936444-4	2014	Treatments with hyperglycaemia (25 mM) or phorbol myristate acetate (PMA, a protein kinase C activator, 100 nM) significantly increased NADPH oxidase activity, O2 ( -) generation, proapoptotic protein Bax expression, TUNEL-positive staining and caspase-3/7 activities.	Tetradecanoylphorbol Acetate	69-72	BCL2 associated X, apoptosis regulator	Homo sapiens	201-204
24871572-4	2014	Luteolin inhibited the secretion of inflammatory cytokines such as interleukin-1beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) from human mast cells (HMC-1) stimulated with phorbol myristate acetate plus calcium ionophore A23187 in a dose-dependent manner.	Tetradecanoylphorbol Acetate	187-212	tumor necrosis factor	Homo sapiens	101-128
24871572-4	2014	Luteolin inhibited the secretion of inflammatory cytokines such as interleukin-1beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) from human mast cells (HMC-1) stimulated with phorbol myristate acetate plus calcium ionophore A23187 in a dose-dependent manner.	Tetradecanoylphorbol Acetate	187-212	tumor necrosis factor	Homo sapiens	130-139
24885456-0	2014	Saussurea lappa extract suppresses TPA-induced cell invasion via inhibition of NF-kappaB-dependent MMP-9 expression in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	35-38	nuclear factor kappa B subunit 1	Homo sapiens	79-88
24885456-11	2014	ESL inhibited the TPA-induced transcriptional activation of nuclear factor-kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	18-21	nuclear factor kappa B subunit 1	Homo sapiens	60-82
24885456-11	2014	ESL inhibited the TPA-induced transcriptional activation of nuclear factor-kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	18-21	nuclear factor kappa B subunit 1	Homo sapiens	84-93
24732112-10	2014	In addition, they showed significant inhibition on PMA induced monocyte to macrophage differentiation and the gene expression of CD14, TLR2 and TLR4 markers.	Tetradecanoylphorbol Acetate	51-54	toll like receptor 2	Homo sapiens	135-139
24631338-5	2014	TTGE blocked the induction of iNOS and COX-2 through the regulation of NF-kappaB and STAT3, which could explain the reduced TPA-induced edema symptoms.	Tetradecanoylphorbol Acetate	124-127	nitric oxide synthase 2, inducible	Mus musculus	30-34
24631338-5	2014	TTGE blocked the induction of iNOS and COX-2 through the regulation of NF-kappaB and STAT3, which could explain the reduced TPA-induced edema symptoms.	Tetradecanoylphorbol Acetate	124-127	signal transducer and activator of transcription 3	Mus musculus	85-90
24286317-0	2014	Down-modulation of Bis reduces the invasive ability of glioma cells induced by TPA, through NF-kappaB mediated activation of MMP-9.	Tetradecanoylphorbol Acetate	79-82	nuclear factor kappa B subunit 1	Homo sapiens	92-101
24796531-6	2014	c-Jun increased expression of SPPR3 mainly via a PKC/JNK pathway in response to TPA in KYSE450 cells.	Tetradecanoylphorbol Acetate	80-83	mitogen-activated protein kinase 8	Homo sapiens	53-56
24286317-7	2014	Finally, we demonstrated that the rapid phosphorylation and subsequent degradation of IkappaB-alpha induced by TPA was remarkably delayed by Bis knockdown.	Tetradecanoylphorbol Acetate	111-114	NFKB inhibitor alpha	Homo sapiens	86-99
24584901-4	2014	For this purpose, THP-1 cells were treated with 100 nM phorbol 12-myristate 13-acetate (PMA) to induce their differentiation into macrophages.	Tetradecanoylphorbol Acetate	55-86	GLI family zinc finger 2	Homo sapiens	18-23
24464785-5	2014	The dependency on RasGRP1 was associated with a diminished response to the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	104-140	RAS guanyl releasing protein 1	Mus musculus	18-25
24464785-5	2014	The dependency on RasGRP1 was associated with a diminished response to the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	142-145	RAS guanyl releasing protein 1	Mus musculus	18-25
24464785-7	2014	Using a keratinocyte cell line that carries a ras oncogenic mutation, we also demonstrated that RasGRP1 could further activate Ras in response to TPA.	Tetradecanoylphorbol Acetate	146-149	RAS guanyl releasing protein 1	Mus musculus	96-103
24604087-0	2014	Decursin prevents TPA-induced invasion through suppression of PKCalpha/p38/NF-kappaB-dependent MMP-9 expression in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	18-21	protein kinase C alpha	Homo sapiens	62-70
24681727-4	2014	In this study, it was demonstrated that in vitro, MAP4K4 deletion remarkably suppressed CD4(+) T cell proliferation in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin, which was not due to enhancing cell apoptosis.	Tetradecanoylphorbol Acetate	131-162	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	50-56
24681727-4	2014	In this study, it was demonstrated that in vitro, MAP4K4 deletion remarkably suppressed CD4(+) T cell proliferation in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin, which was not due to enhancing cell apoptosis.	Tetradecanoylphorbol Acetate	131-162	CD4 molecule	Homo sapiens	88-91
24681727-4	2014	In this study, it was demonstrated that in vitro, MAP4K4 deletion remarkably suppressed CD4(+) T cell proliferation in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin, which was not due to enhancing cell apoptosis.	Tetradecanoylphorbol Acetate	164-167	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	50-56
24681727-4	2014	In this study, it was demonstrated that in vitro, MAP4K4 deletion remarkably suppressed CD4(+) T cell proliferation in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin, which was not due to enhancing cell apoptosis.	Tetradecanoylphorbol Acetate	164-167	CD4 molecule	Homo sapiens	88-91
24589569-5	2014	TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187.	Tetradecanoylphorbol Acetate	143-174	tumor necrosis factor	Homo sapiens	76-109
24589569-5	2014	TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187.	Tetradecanoylphorbol Acetate	143-174	interleukin 6	Homo sapiens	111-129
24604087-0	2014	Decursin prevents TPA-induced invasion through suppression of PKCalpha/p38/NF-kappaB-dependent MMP-9 expression in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	18-21	mitogen-activated protein kinase 14	Homo sapiens	71-74
24604087-0	2014	Decursin prevents TPA-induced invasion through suppression of PKCalpha/p38/NF-kappaB-dependent MMP-9 expression in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	18-21	nuclear factor kappa B subunit 1	Homo sapiens	75-84
24604087-6	2014	Our results showed that decursin inhibits TPA-induced MMP-9 expression and cell invasion through the suppression of NF-kappaB.	Tetradecanoylphorbol Acetate	42-45	nuclear factor kappa B subunit 1	Homo sapiens	116-125
24604087-7	2014	Furthermore, decursin repressed the TPA-induced phosphorylation of p38 MAPK and inhibited TPA-induced translocation of PKCalpha from the cytosol to the membrane, but did not affect the translocation of PKCdelta.	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase 14	Homo sapiens	67-70
24604087-7	2014	Furthermore, decursin repressed the TPA-induced phosphorylation of p38 MAPK and inhibited TPA-induced translocation of PKCalpha from the cytosol to the membrane, but did not affect the translocation of PKCdelta.	Tetradecanoylphorbol Acetate	90-93	protein kinase C alpha	Homo sapiens	119-127
24589569-5	2014	TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187.	Tetradecanoylphorbol Acetate	143-174	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
24589569-5	2014	TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187.	Tetradecanoylphorbol Acetate	176-179	tumor necrosis factor	Homo sapiens	76-109
24589569-5	2014	TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187.	Tetradecanoylphorbol Acetate	176-179	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
24604087-8	2014	These results indicate that decursin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKCalpha, MAPK and NF-kappaB pathways in MCF-7 cells.	Tetradecanoylphorbol Acetate	60-63	protein kinase C alpha	Homo sapiens	139-147
24584901-4	2014	For this purpose, THP-1 cells were treated with 100 nM phorbol 12-myristate 13-acetate (PMA) to induce their differentiation into macrophages.	Tetradecanoylphorbol Acetate	88-91	GLI family zinc finger 2	Homo sapiens	18-23
24604087-8	2014	These results indicate that decursin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKCalpha, MAPK and NF-kappaB pathways in MCF-7 cells.	Tetradecanoylphorbol Acetate	60-63	nuclear factor kappa B subunit 1	Homo sapiens	158-167
24608858-10	2014	We found that acute activation of PKC with phorbol 12-myristate 13-acetate shortened carbachol-evoked calcium responses and occluded the effect of overexpressed DGKeta.	Tetradecanoylphorbol Acetate	43-74	diacylglycerol kinase eta	Homo sapiens	161-167
25436216-12	2014	CONCLUSION: We found that the disparities observed in tPA use were attenuated after adjustment for time from LSN-to-ED arrival, suggesting an area for future intervention.	Tetradecanoylphorbol Acetate	54-57	sialophorin	Homo sapiens	109-112
23913269-5	2014	The aim of this study was to characterize the interactions between TG2 and sPLA2 in LPS-stimulated THP-1 cells, which were treated with TPA to induce early differentiated macrophage-type model.	Tetradecanoylphorbol Acetate	136-139	transglutaminase 2	Homo sapiens	67-70
24753527-5	2014	Mitochondrial dysfunction in children with autism was accompanied by a lower (26% of TD children) oxidative burst by PMA-stimulated reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase and by a lower gene expression (45% of TD children"s mean values) of the nuclear factor erythroid 2-related factor 2 transcription factor involved in the antioxidant response.	Tetradecanoylphorbol Acetate	117-120	NFE2 like bZIP transcription factor 2	Homo sapiens	273-316
24732179-8	2014	Compared with control group, cisplatin and PMA, a protein kinase C activator, both increased endothelial nitric oxide synthase-Thr495 phosphorylation, while propofol and GFX, a protein kinase C inhibitor, both decreased cisplatin-induced endothelial nitric oxide synthase-Thr495 phosphorylation.	Tetradecanoylphorbol Acetate	43-46	nitric oxide synthase 3	Homo sapiens	93-126
24732179-8	2014	Compared with control group, cisplatin and PMA, a protein kinase C activator, both increased endothelial nitric oxide synthase-Thr495 phosphorylation, while propofol and GFX, a protein kinase C inhibitor, both decreased cisplatin-induced endothelial nitric oxide synthase-Thr495 phosphorylation.	Tetradecanoylphorbol Acetate	43-46	nitric oxide synthase 3	Homo sapiens	238-271
24699135-5	2014	LR11 was not expressed in THP-1 monocytes, but it was expressed and released in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 macrophages (PMA/THP-1).	Tetradecanoylphorbol Acetate	80-111	GLI family zinc finger 2	Homo sapiens	126-131
24699135-5	2014	LR11 was not expressed in THP-1 monocytes, but it was expressed and released in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 macrophages (PMA/THP-1).	Tetradecanoylphorbol Acetate	80-111	GLI family zinc finger 2	Homo sapiens	126-131
24699135-5	2014	LR11 was not expressed in THP-1 monocytes, but it was expressed and released in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 macrophages (PMA/THP-1).	Tetradecanoylphorbol Acetate	113-116	GLI family zinc finger 2	Homo sapiens	126-131
24699135-5	2014	LR11 was not expressed in THP-1 monocytes, but it was expressed and released in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 macrophages (PMA/THP-1).	Tetradecanoylphorbol Acetate	113-116	GLI family zinc finger 2	Homo sapiens	126-131
24699135-9	2014	Likewise, the PMA-stimulated release of sLR11 increased in THP-1 cells transfected with CD9-targeted shRNAs, which was negated by treatment with the metalloproteinase inhibitor GM6001.	Tetradecanoylphorbol Acetate	14-17	GLI family zinc finger 2	Homo sapiens	59-64
24637716-5	2014	Conversely, THAP11 overexpression accelerated the megakaryocytic differentiation induced by phorbol myristate acetate (PMA) with increased percentage of CD41+ cells, increased numbers of 4N cells, and elevated CD61 mRNA levels, and THAP11 knockdown attenuated the megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	92-117	THAP domain containing 11	Homo sapiens	12-18
24682423-5	2014	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) resulted in a strong reduction of Kv1.5/Kvbeta1.2 current.	Tetradecanoylphorbol Acetate	23-54	protein kinase C alpha	Homo sapiens	14-17
24682423-5	2014	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) resulted in a strong reduction of Kv1.5/Kvbeta1.2 current.	Tetradecanoylphorbol Acetate	23-54	potassium voltage-gated channel subfamily A member 5	Homo sapiens	95-100
24682423-5	2014	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) resulted in a strong reduction of Kv1.5/Kvbeta1.2 current.	Tetradecanoylphorbol Acetate	56-59	protein kinase C alpha	Homo sapiens	14-17
24682423-5	2014	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) resulted in a strong reduction of Kv1.5/Kvbeta1.2 current.	Tetradecanoylphorbol Acetate	56-59	potassium voltage-gated channel subfamily A member 5	Homo sapiens	95-100
24743307-6	2014	Furthermore, we found that CSB occupancy is enriched at sites containing the TPA-response element.	Tetradecanoylphorbol Acetate	77-80	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	27-30
24743307-8	2014	In support of this notion, we observed decreased CSB occupancy of TPA-response elements when c-Jun levels were diminished.	Tetradecanoylphorbol Acetate	66-69	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	49-52
24421112-4	2014	Moreover, treatment with known ERK activators such as phorbol 12-myristate 13-acetate and serum increased viral yields whereas ERK silencing by small interfering RNAs caused the inhibition of viral multiplication.	Tetradecanoylphorbol Acetate	54-85	mitogen-activated protein kinase 1	Homo sapiens	31-34
24532790-0	2014	12-O-tetradecanoylphorbol-13-acetate promotes breast cancer cell motility by increasing S100A14 level in a Kruppel-like transcription factor 4 (KLF4)-dependent manner.	Tetradecanoylphorbol Acetate	0-36	S100 calcium binding protein A14	Homo sapiens	88-95
24532790-5	2014	Here, we determined that 12-O-tetradecanoylphorbol-13-acetate (TPA) up-regulated the expression of KLF4 and facilitated its binding directly to two conserved GC-rich DNA segments within the S100A14 promoter, which is essential for the transactivation of KLF4 induced S100A14 expression.	Tetradecanoylphorbol Acetate	25-61	S100 calcium binding protein A14	Homo sapiens	190-197
24532790-5	2014	Here, we determined that 12-O-tetradecanoylphorbol-13-acetate (TPA) up-regulated the expression of KLF4 and facilitated its binding directly to two conserved GC-rich DNA segments within the S100A14 promoter, which is essential for the transactivation of KLF4 induced S100A14 expression.	Tetradecanoylphorbol Acetate	25-61	S100 calcium binding protein A14	Homo sapiens	267-274
24532790-5	2014	Here, we determined that 12-O-tetradecanoylphorbol-13-acetate (TPA) up-regulated the expression of KLF4 and facilitated its binding directly to two conserved GC-rich DNA segments within the S100A14 promoter, which is essential for the transactivation of KLF4 induced S100A14 expression.	Tetradecanoylphorbol Acetate	63-66	S100 calcium binding protein A14	Homo sapiens	190-197
24532790-5	2014	Here, we determined that 12-O-tetradecanoylphorbol-13-acetate (TPA) up-regulated the expression of KLF4 and facilitated its binding directly to two conserved GC-rich DNA segments within the S100A14 promoter, which is essential for the transactivation of KLF4 induced S100A14 expression.	Tetradecanoylphorbol Acetate	63-66	S100 calcium binding protein A14	Homo sapiens	267-274
24532790-7	2014	Collectively, these results offer insights into the fact that TPA provokes cell motility through regulating the expression and function of S100A14 in a KLF4-dependent manner.	Tetradecanoylphorbol Acetate	62-65	S100 calcium binding protein A14	Homo sapiens	139-146
24637716-5	2014	Conversely, THAP11 overexpression accelerated the megakaryocytic differentiation induced by phorbol myristate acetate (PMA) with increased percentage of CD41+ cells, increased numbers of 4N cells, and elevated CD61 mRNA levels, and THAP11 knockdown attenuated the megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	119-122	THAP domain containing 11	Homo sapiens	12-18
24637716-5	2014	Conversely, THAP11 overexpression accelerated the megakaryocytic differentiation induced by phorbol myristate acetate (PMA) with increased percentage of CD41+ cells, increased numbers of 4N cells, and elevated CD61 mRNA levels, and THAP11 knockdown attenuated the megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	119-122	THAP domain containing 11	Homo sapiens	232-238
23913269-5	2014	The aim of this study was to characterize the interactions between TG2 and sPLA2 in LPS-stimulated THP-1 cells, which were treated with TPA to induce early differentiated macrophage-type model.	Tetradecanoylphorbol Acetate	136-139	GLI family zinc finger 2	Homo sapiens	99-104
23913269-8	2014	Concomitantly, the PLA2 enzyme activity increased in TPA-treated cells exposed to LPS; these high levels of enzyme activity were significant reduced by R283, a site-specific inhibitor of TG2.	Tetradecanoylphorbol Acetate	53-56	phospholipase A2 group IB	Homo sapiens	19-23
23913269-8	2014	Concomitantly, the PLA2 enzyme activity increased in TPA-treated cells exposed to LPS; these high levels of enzyme activity were significant reduced by R283, a site-specific inhibitor of TG2.	Tetradecanoylphorbol Acetate	53-56	transglutaminase 2	Homo sapiens	187-190
24441674-0	2014	Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane.	Tetradecanoylphorbol Acetate	83-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
24160248-7	2014	Moreover, the expression of P-selectin induced by TPA was abrogated by POH and significantly lower serum concentrations of IL-6 and TNF-alpha were observed in d-Limonene- and POH-treated mice (p&lt;0.04 and 0.03).	Tetradecanoylphorbol Acetate	50-53	selectin, platelet	Mus musculus	28-38
24441674-3	2014	In this study, we investigated the inhibitory role and epigenetics of Nrf2 on tumor transformation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin epidermal JB6 (JB6 P+) cells and the anticancer effect of sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables.	Tetradecanoylphorbol Acetate	110-146	nuclear factor, erythroid derived 2, like 2	Mus musculus	70-74
24441674-9	2014	Collectively, these results suggest that the anti-cancer effect of SFN against TPA-induced neoplastic transformation of mouse skin could involve the epigenetic reprogramming of anti-cancer genes such as Nrf2, leading to the epigenetic reactivation of Nrf2 and the subsequent induction of downstream target genes involved in cellular protection.	Tetradecanoylphorbol Acetate	79-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	203-207
24441674-9	2014	Collectively, these results suggest that the anti-cancer effect of SFN against TPA-induced neoplastic transformation of mouse skin could involve the epigenetic reprogramming of anti-cancer genes such as Nrf2, leading to the epigenetic reactivation of Nrf2 and the subsequent induction of downstream target genes involved in cellular protection.	Tetradecanoylphorbol Acetate	79-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	251-255
24441674-3	2014	In this study, we investigated the inhibitory role and epigenetics of Nrf2 on tumor transformation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin epidermal JB6 (JB6 P+) cells and the anticancer effect of sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables.	Tetradecanoylphorbol Acetate	148-151	nuclear factor, erythroid derived 2, like 2	Mus musculus	70-74
24441674-5	2014	Knockdown of Nrf2 attenuated the induction of Nrf2, HO-1 and NQO1 by SFN, enhanced TPA-induced colony formation and dampened the inhibitory effect of SFN on TPA-induced JB6 transformation.	Tetradecanoylphorbol Acetate	83-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
24441674-5	2014	Knockdown of Nrf2 attenuated the induction of Nrf2, HO-1 and NQO1 by SFN, enhanced TPA-induced colony formation and dampened the inhibitory effect of SFN on TPA-induced JB6 transformation.	Tetradecanoylphorbol Acetate	157-160	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
24138399-5	2014	A total of 300 heterocyclic compounds with 70% similarity to phorbol 12-myristate 13-acetate (PMA) were selected, and virtual docking was performed with PKC-alpha as target.	Tetradecanoylphorbol Acetate	94-97	protein kinase C alpha	Homo sapiens	153-162
24334270-8	2014	TPA also inhibited the TGF-beta1-induced apoptosis of Huh7 cells, stimulating the degradation of the PDCD4-protein.	Tetradecanoylphorbol Acetate	0-3	transforming growth factor beta 1	Homo sapiens	23-32
24464647-7	2014	We examined intracellular ERK1/2 phosphorylation and IFN-gamma production by CD4+ and CD8+ T cells upon polyclonal stimulation with PMA and ionomycin, while monitoring expression of the cytolytic molecule perforin and the T cell activation marker CD38.	Tetradecanoylphorbol Acetate	132-135	mitogen-activated protein kinase 3	Homo sapiens	26-32
24464647-7	2014	We examined intracellular ERK1/2 phosphorylation and IFN-gamma production by CD4+ and CD8+ T cells upon polyclonal stimulation with PMA and ionomycin, while monitoring expression of the cytolytic molecule perforin and the T cell activation marker CD38.	Tetradecanoylphorbol Acetate	132-135	interferon gamma	Homo sapiens	53-62
24138399-8	2014	In addition, as these compounds showed better binding than PMA, more interaction with PKC residues (hydrogen bonding and hydrophobic), and the top five hit molecules was potent enough to abolish carcinogenic effects of PMA.	Tetradecanoylphorbol Acetate	59-62	protein kinase C alpha	Homo sapiens	86-89
24252747-9	2014	Coordinate up-regulation of Nnat and involucrin, but not cytokeratin1, was demonstrated in cultured keratinocytes under differentiation stimuli such as extracellular calcium elevation, exposure to phorbol myristate acetate, and increased cell density.	Tetradecanoylphorbol Acetate	197-222	involucrin	Homo sapiens	37-47
24246020-7	2014	After being co-cultured with Phorbol 12-myristate 13-acetate, ionomycin and monensin, the expression level of interferon (IFN)-gamma in the dNK cells was detected by FCM.	Tetradecanoylphorbol Acetate	29-60	interferon gamma	Homo sapiens	110-132
24456812-8	2014	We further show that TPA specifically activates the shedding of alphaM/beta2 integrin (Mac-1), which was not shed upon LPS-stimulation of macrophages.	Tetradecanoylphorbol Acetate	21-24	integrin alpha M	Mus musculus	87-92
24345644-3	2014	Since prior studies demonstrated cyclooxygenase 2 (COX-2) is necessary for DMBA/TPA tumor induction, we hypothesized that COX-2 inhibition might prevent BRAFi-accelerated skin tumors.	Tetradecanoylphorbol Acetate	80-83	prostaglandin-endoperoxide synthase 2	Homo sapiens	33-49
24345644-3	2014	Since prior studies demonstrated cyclooxygenase 2 (COX-2) is necessary for DMBA/TPA tumor induction, we hypothesized that COX-2 inhibition might prevent BRAFi-accelerated skin tumors.	Tetradecanoylphorbol Acetate	80-83	prostaglandin-endoperoxide synthase 2	Homo sapiens	51-56
24345644-3	2014	Since prior studies demonstrated cyclooxygenase 2 (COX-2) is necessary for DMBA/TPA tumor induction, we hypothesized that COX-2 inhibition might prevent BRAFi-accelerated skin tumors.	Tetradecanoylphorbol Acetate	80-83	prostaglandin-endoperoxide synthase 2	Homo sapiens	122-127
24335814-1	2014	BACKGROUND: Carotid endarterectomy (CEA) for symptomatic carotid artery stenosis and intravenous tissue-type plasminogen activator (IV-tPA) for acute ischemic stroke are proven therapies; however, the safety of CEA in stroke patients who recently received IV-tPA has not been established.	Tetradecanoylphorbol Acetate	135-138	plasminogen activator, tissue type	Homo sapiens	97-130
24161965-6	2014	Treatment with phorbol 12-myristate 13-acetate (PMA), the protein kinase C (PKC) activator, stimulated MAPK/ERK pathway in GL-1, UL-1 and Ema cells and JNK pathway in UL-1 and Ema cells.	Tetradecanoylphorbol Acetate	15-46	mitogen-activated protein kinase 1	Mus musculus	103-107
24161965-6	2014	Treatment with phorbol 12-myristate 13-acetate (PMA), the protein kinase C (PKC) activator, stimulated MAPK/ERK pathway in GL-1, UL-1 and Ema cells and JNK pathway in UL-1 and Ema cells.	Tetradecanoylphorbol Acetate	15-46	mitogen-activated protein kinase 1	Mus musculus	108-111
24161965-6	2014	Treatment with phorbol 12-myristate 13-acetate (PMA), the protein kinase C (PKC) activator, stimulated MAPK/ERK pathway in GL-1, UL-1 and Ema cells and JNK pathway in UL-1 and Ema cells.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 1	Mus musculus	103-107
24161965-6	2014	Treatment with phorbol 12-myristate 13-acetate (PMA), the protein kinase C (PKC) activator, stimulated MAPK/ERK pathway in GL-1, UL-1 and Ema cells and JNK pathway in UL-1 and Ema cells.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 1	Mus musculus	108-111
23396363-8	2014	Finally, activation of GADD153, an AP-1 target gene, is also associated with a rapid increase in SUMOylation at the level of its TRE and c-Fos SUMOylation dampens its induction by TPA.	Tetradecanoylphorbol Acetate	180-183	DNA damage inducible transcript 3	Homo sapiens	23-30
24461294-7	2014	Conversely, PKC promoter phorbol 12-myristate 13-acetate (PMA) and JNK inhibitor SP600125 reversed the cleavages of caspase 3 and PARP induced by GA in NCI-H460 cells.	Tetradecanoylphorbol Acetate	25-56	protein kinase C alpha	Homo sapiens	12-15
24461294-7	2014	Conversely, PKC promoter phorbol 12-myristate 13-acetate (PMA) and JNK inhibitor SP600125 reversed the cleavages of caspase 3 and PARP induced by GA in NCI-H460 cells.	Tetradecanoylphorbol Acetate	25-56	caspase 3	Homo sapiens	116-125
24461294-7	2014	Conversely, PKC promoter phorbol 12-myristate 13-acetate (PMA) and JNK inhibitor SP600125 reversed the cleavages of caspase 3 and PARP induced by GA in NCI-H460 cells.	Tetradecanoylphorbol Acetate	25-56	poly(ADP-ribose) polymerase 1	Homo sapiens	130-134
24461294-7	2014	Conversely, PKC promoter phorbol 12-myristate 13-acetate (PMA) and JNK inhibitor SP600125 reversed the cleavages of caspase 3 and PARP induced by GA in NCI-H460 cells.	Tetradecanoylphorbol Acetate	58-61	protein kinase C alpha	Homo sapiens	12-15
24461294-7	2014	Conversely, PKC promoter phorbol 12-myristate 13-acetate (PMA) and JNK inhibitor SP600125 reversed the cleavages of caspase 3 and PARP induced by GA in NCI-H460 cells.	Tetradecanoylphorbol Acetate	58-61	caspase 3	Homo sapiens	116-125
24461294-7	2014	Conversely, PKC promoter phorbol 12-myristate 13-acetate (PMA) and JNK inhibitor SP600125 reversed the cleavages of caspase 3 and PARP induced by GA in NCI-H460 cells.	Tetradecanoylphorbol Acetate	58-61	poly(ADP-ribose) polymerase 1	Homo sapiens	130-134
24286866-4	2014	TIM-1 and TIM-4 lacking the intracellular domain were efficiently cleaved after ionomycin- and PMA-treatment, indicating that the intracellular domain was not necessary for ectodomain shedding.	Tetradecanoylphorbol Acetate	95-98	T cell immunoglobulin and mucin domain containing 4	Homo sapiens	10-15
24362330-0	2014	Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models.	Tetradecanoylphorbol Acetate	0-31	ATP binding cassette subfamily B member 1	Homo sapiens	93-97
24362330-10	2014	In agreement with the above results, PMA dose-dependently reduced intracellular ATP level and stimulated P-gp ATPase activity in both Caco-2 and MDCKII-MDR1 cells.	Tetradecanoylphorbol Acetate	37-40	ATP binding cassette subfamily B member 1	Homo sapiens	152-156
24362330-12	2014	CONCLUSION: PMA significantly inhibited P-gp-mediated efflux of digoxin in both Caco-2 and MDCKII-MDR1 cell monolayers via PKC activation.	Tetradecanoylphorbol Acetate	12-15	ATP binding cassette subfamily B member 1	Homo sapiens	98-102
24499192-4	2014	RESULTS: It was found that PCN increased IL-8 release and mRNA expression in Phorbol 12-myristate 13-acetate (PMA) differentiated U937 cells in both a concentration- and time-dependent manner by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA).	Tetradecanoylphorbol Acetate	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
24753817-11	2014	Overall, these results suggested that TPA induced K8 phosphorylation and reorganization via Tgase-2 expression in PANC-1 cells.	Tetradecanoylphorbol Acetate	38-41	transglutaminase 2	Homo sapiens	92-99
24239722-1	2014	The role of protein kinase C (PKC) isozymes in phorbol myristate acetate (PMA)-induced sphingosine 1-phosphate (S1P) receptor 1 (S1P1) phosphorylation was studied.	Tetradecanoylphorbol Acetate	47-72	protein kinase C alpha	Homo sapiens	30-33
24239722-1	2014	The role of protein kinase C (PKC) isozymes in phorbol myristate acetate (PMA)-induced sphingosine 1-phosphate (S1P) receptor 1 (S1P1) phosphorylation was studied.	Tetradecanoylphorbol Acetate	74-77	protein kinase C alpha	Homo sapiens	30-33
24239722-7	2014	Additionally, expression of dominant-negative mutants of PKC alpha or beta and knockdown of these isozymes using short hairpin RNA, markedly attenuated PMA-induced S1P1 phosphorylation.	Tetradecanoylphorbol Acetate	152-155	protein kinase C alpha	Homo sapiens	57-66
24258363-3	2014	Pretreatment with MSE in mouse skin has led to the reduction of TPA-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunits as well as phosphorylation of IkappaBalpha and p65 subsequent reduction of IkappaBalpha degradation.	Tetradecanoylphorbol Acetate	64-67	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-126
24753817-0	2014	12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin 8 Phosphorylation and Reorganization via Expression of Transglutaminase-2.	Tetradecanoylphorbol Acetate	0-36	transglutaminase 2	Homo sapiens	108-126
24753817-6	2014	TPA induced phosphorylation and reorganization of K8 and transglutaminase-2 (Tgase-2) expression in a time- and dose-dependent manner in PANC-1 cells.	Tetradecanoylphorbol Acetate	0-3	transglutaminase 2	Homo sapiens	57-75
24753817-6	2014	TPA induced phosphorylation and reorganization of K8 and transglutaminase-2 (Tgase-2) expression in a time- and dose-dependent manner in PANC-1 cells.	Tetradecanoylphorbol Acetate	0-3	transglutaminase 2	Homo sapiens	77-84
24753817-8	2014	We next investigated, using cystamine (CTM), Tgase inhibitor, and Tgase-2 gene silencing, Tgase-2"s possible involvement in TPA-induced K8 phosphorylation and reorganization.	Tetradecanoylphorbol Acetate	124-127	transglutaminase 2	Homo sapiens	66-73
24753817-8	2014	We next investigated, using cystamine (CTM), Tgase inhibitor, and Tgase-2 gene silencing, Tgase-2"s possible involvement in TPA-induced K8 phosphorylation and reorganization.	Tetradecanoylphorbol Acetate	124-127	transglutaminase 2	Homo sapiens	90-97
24753817-10	2014	Tgase-2 gene silencing, we additionally discovered, suppressed TPA-induced migration of PANC-1 cells and Tgase-2 overexpression induced migration of PANC-1 cells.	Tetradecanoylphorbol Acetate	63-66	transglutaminase 2	Homo sapiens	0-7
24258363-3	2014	Pretreatment with MSE in mouse skin has led to the reduction of TPA-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunits as well as phosphorylation of IkappaBalpha and p65 subsequent reduction of IkappaBalpha degradation.	Tetradecanoylphorbol Acetate	64-67	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	128-136
24258363-3	2014	Pretreatment with MSE in mouse skin has led to the reduction of TPA-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunits as well as phosphorylation of IkappaBalpha and p65 subsequent reduction of IkappaBalpha degradation.	Tetradecanoylphorbol Acetate	64-67	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	222-234
24258363-4	2014	In addition, the MSE inhibitory effect on upstream of NFkappaB was found to involve the transcriptional effects of MAPK signaling as indicated by strong suppression on TPA-induced activation of extracellular signal regulate kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt.	Tetradecanoylphorbol Acetate	168-171	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	54-62
24258363-4	2014	In addition, the MSE inhibitory effect on upstream of NFkappaB was found to involve the transcriptional effects of MAPK signaling as indicated by strong suppression on TPA-induced activation of extracellular signal regulate kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt.	Tetradecanoylphorbol Acetate	168-171	mitogen-activated protein kinase 1	Mus musculus	115-119
24258363-4	2014	In addition, the MSE inhibitory effect on upstream of NFkappaB was found to involve the transcriptional effects of MAPK signaling as indicated by strong suppression on TPA-induced activation of extracellular signal regulate kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt.	Tetradecanoylphorbol Acetate	168-171	mitogen-activated protein kinase 1	Mus musculus	279-283
24258363-4	2014	In addition, the MSE inhibitory effect on upstream of NFkappaB was found to involve the transcriptional effects of MAPK signaling as indicated by strong suppression on TPA-induced activation of extracellular signal regulate kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt.	Tetradecanoylphorbol Acetate	168-171	thymoma viral proto-oncogene 1	Mus musculus	361-364
24317440-10	2014	Furthermore, in MNK-74 and SC-M1 cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) and 5 or 10 microM of ATPR significantly suppressed the activity of the AP-1 reporter as compared to treatment with ATRA (P&lt;0.05).	Tetradecanoylphorbol Acetate	52-88	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-171
24317440-10	2014	Furthermore, in MNK-74 and SC-M1 cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) and 5 or 10 microM of ATPR significantly suppressed the activity of the AP-1 reporter as compared to treatment with ATRA (P&lt;0.05).	Tetradecanoylphorbol Acetate	90-93	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-171
24465855-0	2014	PEP-1-PON1 protein regulates inflammatory response in raw 264.7 macrophages and ameliorates inflammation in a TPA-induced animal model.	Tetradecanoylphorbol Acetate	110-113	paraoxonase 1	Mus musculus	6-10
24048740-7	2014	Downregulation of clathrin by specific siRNAs directed against its heavy chain abolished the effect of alpha-Syn on phorbol 12-myristate 13-acetate-induced DAT internalization.	Tetradecanoylphorbol Acetate	116-147	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	156-159
24038215-7	2014	In cells treated with phorbol-12-myristate-13-acetate (PMA), apo A-I gene promoter activity was inhibited and apo A-I mRNA content and apo A-I protein secretion decreased.	Tetradecanoylphorbol Acetate	22-53	apolipoprotein A1	Homo sapiens	61-68
24038215-7	2014	In cells treated with phorbol-12-myristate-13-acetate (PMA), apo A-I gene promoter activity was inhibited and apo A-I mRNA content and apo A-I protein secretion decreased.	Tetradecanoylphorbol Acetate	22-53	apolipoprotein A1	Homo sapiens	110-117
24038215-7	2014	In cells treated with phorbol-12-myristate-13-acetate (PMA), apo A-I gene promoter activity was inhibited and apo A-I mRNA content and apo A-I protein secretion decreased.	Tetradecanoylphorbol Acetate	22-53	apolipoprotein A1	Homo sapiens	110-117
24038215-7	2014	In cells treated with phorbol-12-myristate-13-acetate (PMA), apo A-I gene promoter activity was inhibited and apo A-I mRNA content and apo A-I protein secretion decreased.	Tetradecanoylphorbol Acetate	55-58	apolipoprotein A1	Homo sapiens	61-68
24038215-7	2014	In cells treated with phorbol-12-myristate-13-acetate (PMA), apo A-I gene promoter activity was inhibited and apo A-I mRNA content and apo A-I protein secretion decreased.	Tetradecanoylphorbol Acetate	55-58	apolipoprotein A1	Homo sapiens	110-117
24038215-7	2014	In cells treated with phorbol-12-myristate-13-acetate (PMA), apo A-I gene promoter activity was inhibited and apo A-I mRNA content and apo A-I protein secretion decreased.	Tetradecanoylphorbol Acetate	55-58	apolipoprotein A1	Homo sapiens	110-117
24465855-5	2014	Furthermore, topically applied PEP-1-PON1 protein ameliorates TPA-treated mice skin inflammation via a reduction of inflammatory response.	Tetradecanoylphorbol Acetate	62-65	paraoxonase 1	Mus musculus	37-41
24433534-6	2014	Gen suppressed TPA-induced AP-1 activity through inhibitory phosphorylation of extracellular signal-related kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathways, and TPA-stimulated inhibition of NF-kappaB nuclear translocation through IkappaB inhibitory signaling pathways.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 8	Homo sapiens	125-148
24447339-2	2014	Phorbol 12-myristate 13-acetate (PMA), a well-known PKC activator, increases the cytotoxicity of several anticancer drugs.	Tetradecanoylphorbol Acetate	0-31	protein kinase C alpha	Homo sapiens	52-55
24447339-2	2014	Phorbol 12-myristate 13-acetate (PMA), a well-known PKC activator, increases the cytotoxicity of several anticancer drugs.	Tetradecanoylphorbol Acetate	33-36	protein kinase C alpha	Homo sapiens	52-55
24433534-6	2014	Gen suppressed TPA-induced AP-1 activity through inhibitory phosphorylation of extracellular signal-related kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathways, and TPA-stimulated inhibition of NF-kappaB nuclear translocation through IkappaB inhibitory signaling pathways.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 8	Homo sapiens	150-153
24433534-6	2014	Gen suppressed TPA-induced AP-1 activity through inhibitory phosphorylation of extracellular signal-related kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling pathways, and TPA-stimulated inhibition of NF-kappaB nuclear translocation through IkappaB inhibitory signaling pathways.	Tetradecanoylphorbol Acetate	179-182	nuclear factor kappa B subunit 1	Homo sapiens	208-217
24433534-7	2014	Moreover, Gen suppressed TPA-induced activation of ERK/phosphatidylinositol 3-kinase/Akt upstream of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	25-28	AKT serine/threonine kinase 1	Homo sapiens	85-88
24433534-7	2014	Moreover, Gen suppressed TPA-induced activation of ERK/phosphatidylinositol 3-kinase/Akt upstream of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	25-28	nuclear factor kappa B subunit 1	Homo sapiens	101-110
24269601-5	2014	Further investigation revealed that the cells were classically activated by the differentiation agent phorbol 12-myristate 13-acetate (PMA) as shown by induction of chemokine receptor CCR7.	Tetradecanoylphorbol Acetate	102-133	C-C motif chemokine receptor 7	Homo sapiens	184-188
24269601-5	2014	Further investigation revealed that the cells were classically activated by the differentiation agent phorbol 12-myristate 13-acetate (PMA) as shown by induction of chemokine receptor CCR7.	Tetradecanoylphorbol Acetate	135-138	C-C motif chemokine receptor 7	Homo sapiens	184-188
24894548-3	2014	Lipopolysachharide (LPS) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced production of proinflammatory cytokines (TNF-alpha and IL-6) in macrophage cells as well as in TPA-induced skin inflammation in mice was significantly inhibited by alpha-(-)-bisabolol.	Tetradecanoylphorbol Acetate	29-66	tumor necrosis factor	Mus musculus	122-131
25307224-1	2014	To date, tissue type plasminogen activator (tPA)-based thrombolytic stroke therapy is the only FDA-approved treatment for achieving vascular reperfusion and clinical benefit, but this agent is given to only about 5% of stroke patients in the USA.	Tetradecanoylphorbol Acetate	44-47	plasminogen activator, tissue type	Homo sapiens	9-42
24894548-3	2014	Lipopolysachharide (LPS) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced production of proinflammatory cytokines (TNF-alpha and IL-6) in macrophage cells as well as in TPA-induced skin inflammation in mice was significantly inhibited by alpha-(-)-bisabolol.	Tetradecanoylphorbol Acetate	29-66	interleukin 6	Mus musculus	136-140
24894548-3	2014	Lipopolysachharide (LPS) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced production of proinflammatory cytokines (TNF-alpha and IL-6) in macrophage cells as well as in TPA-induced skin inflammation in mice was significantly inhibited by alpha-(-)-bisabolol.	Tetradecanoylphorbol Acetate	68-71	tumor necrosis factor	Mus musculus	122-131
24894548-3	2014	Lipopolysachharide (LPS) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced production of proinflammatory cytokines (TNF-alpha and IL-6) in macrophage cells as well as in TPA-induced skin inflammation in mice was significantly inhibited by alpha-(-)-bisabolol.	Tetradecanoylphorbol Acetate	68-71	interleukin 6	Mus musculus	136-140
24894548-3	2014	Lipopolysachharide (LPS) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced production of proinflammatory cytokines (TNF-alpha and IL-6) in macrophage cells as well as in TPA-induced skin inflammation in mice was significantly inhibited by alpha-(-)-bisabolol.	Tetradecanoylphorbol Acetate	176-179	tumor necrosis factor	Mus musculus	122-131
24894548-3	2014	Lipopolysachharide (LPS) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced production of proinflammatory cytokines (TNF-alpha and IL-6) in macrophage cells as well as in TPA-induced skin inflammation in mice was significantly inhibited by alpha-(-)-bisabolol.	Tetradecanoylphorbol Acetate	176-179	interleukin 6	Mus musculus	136-140
24173318-7	2014	Luciferase assays showed that HF decreases TPA-induced MMP-9 promoter binding activities of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	43-46	nuclear factor kappa B subunit 1	Homo sapiens	92-101
26229980-3	2014	Previous studies, using phorbol-myristate-acetate (PMA) as a differentiating agent, have suggested that the CD34+/CD38+ TF-1 cell line may be used as one model to study the differentiation processes of HPCs.	Tetradecanoylphorbol Acetate	24-49	CD34 molecule	Homo sapiens	108-112
24706270-8	2014	By stimulation of PBMCs with PMA/ionomycin for 6 h, more than 1-2 % of total CD8 T cells are identified as positive in terms of multifunctionality, thus producing multiple cytokines--IL-2, TNFalpha, and IFNgamma--at single-cell level in case of all healthy donors.	Tetradecanoylphorbol Acetate	29-32	interleukin 2	Homo sapiens	183-187
24706270-8	2014	By stimulation of PBMCs with PMA/ionomycin for 6 h, more than 1-2 % of total CD8 T cells are identified as positive in terms of multifunctionality, thus producing multiple cytokines--IL-2, TNFalpha, and IFNgamma--at single-cell level in case of all healthy donors.	Tetradecanoylphorbol Acetate	29-32	tumor necrosis factor	Homo sapiens	189-197
24706270-8	2014	By stimulation of PBMCs with PMA/ionomycin for 6 h, more than 1-2 % of total CD8 T cells are identified as positive in terms of multifunctionality, thus producing multiple cytokines--IL-2, TNFalpha, and IFNgamma--at single-cell level in case of all healthy donors.	Tetradecanoylphorbol Acetate	29-32	interferon gamma	Homo sapiens	203-211
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	melanoma antigen	Mus musculus	40-44
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	tumor necrosis factor	Mus musculus	281-308
26229980-3	2014	Previous studies, using phorbol-myristate-acetate (PMA) as a differentiating agent, have suggested that the CD34+/CD38+ TF-1 cell line may be used as one model to study the differentiation processes of HPCs.	Tetradecanoylphorbol Acetate	51-54	CD34 molecule	Homo sapiens	108-112
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	tumor necrosis factor	Mus musculus	310-319
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	interleukin 1 beta	Mus musculus	322-330
24557496-7	2014	Moreover, ezetimibe suppressed the promoter activity of TNF-alpha but not TNF-alpha lacking the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) binding domain in THP-1 cells treated with phorbol myristate acetate and Chol:MbetaCD.	Tetradecanoylphorbol Acetate	214-239	tumor necrosis factor	Homo sapiens	56-65
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	interleukin 6	Mus musculus	336-340
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	tumor necrosis factor	Mus musculus	373-382
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	interleukin 1 beta	Mus musculus	384-392
23983093-4	2014	In addition, topical application with MEFA or MELA effectively attenuated tumor incidence, multiplicity, volume, malignancy as well as angiogenesis of TPA-stimulated skin tumor promotion in DMBA-initiated mice.	Tetradecanoylphorbol Acetate	151-154	melanoma antigen	Mus musculus	46-50
24672638-6	2014	Western blot analysis documented that resveratrol in concentrations of 10 and 100 muM significantly decreased PMA-induced phosphorylation of PKC alpha/beta II.	Tetradecanoylphorbol Acetate	110-113	protein kinase C alpha	Homo sapiens	141-158
24220687-0	2014	Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression.	Tetradecanoylphorbol Acetate	73-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
24220687-5	2014	The results showed that sanguinarine inhibited TPA-induced MMP-9 and COX-2 mRNA and protein expression in a dose-dependent manner at non-cytotoxic concentrations.	Tetradecanoylphorbol Acetate	47-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
24557496-7	2014	Moreover, ezetimibe suppressed the promoter activity of TNF-alpha but not TNF-alpha lacking the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) binding domain in THP-1 cells treated with phorbol myristate acetate and Chol:MbetaCD.	Tetradecanoylphorbol Acetate	214-239	nuclear factor kappa B subunit 1	Homo sapiens	160-169
24611083-6	2014	The frequency of IFN-gamma+/tumor necrosis factor-alpha (TNF-alpha)+CD45RO+CD4+ T-cells upon stimulation with phorbol myristate acetate (PMA)/Ionomycin was higher in 2-3 months old infants who received BCG vaccination at birth compared to those who did not.	Tetradecanoylphorbol Acetate	110-135	interferon gamma	Homo sapiens	17-26
24117612-3	2014	The expression of CD40L on activated CD4(+) T cells was higher in patients with pSS than controls after phorbolmyristate acetate and ionomycin activation (P = 0.02).	Tetradecanoylphorbol Acetate	104-128	CD40 ligand	Homo sapiens	18-23
24117612-3	2014	The expression of CD40L on activated CD4(+) T cells was higher in patients with pSS than controls after phorbolmyristate acetate and ionomycin activation (P = 0.02).	Tetradecanoylphorbol Acetate	104-128	CD4 molecule	Homo sapiens	18-21
24611083-6	2014	The frequency of IFN-gamma+/tumor necrosis factor-alpha (TNF-alpha)+CD45RO+CD4+ T-cells upon stimulation with phorbol myristate acetate (PMA)/Ionomycin was higher in 2-3 months old infants who received BCG vaccination at birth compared to those who did not.	Tetradecanoylphorbol Acetate	110-135	tumor necrosis factor	Homo sapiens	57-66
24611083-6	2014	The frequency of IFN-gamma+/tumor necrosis factor-alpha (TNF-alpha)+CD45RO+CD4+ T-cells upon stimulation with phorbol myristate acetate (PMA)/Ionomycin was higher in 2-3 months old infants who received BCG vaccination at birth compared to those who did not.	Tetradecanoylphorbol Acetate	137-140	interferon gamma	Homo sapiens	17-26
24611083-6	2014	The frequency of IFN-gamma+/tumor necrosis factor-alpha (TNF-alpha)+CD45RO+CD4+ T-cells upon stimulation with phorbol myristate acetate (PMA)/Ionomycin was higher in 2-3 months old infants who received BCG vaccination at birth compared to those who did not.	Tetradecanoylphorbol Acetate	137-140	tumor necrosis factor	Homo sapiens	57-66
24211779-6	2013	Treatment of HUVECs with H2O2 or phorbol myristate acetate (PMA) led to tyrosine phosphorylation of VE-cadherin, dissociation of beta-catenin from VE-cadherin complex and increased transendothelial migration (TEM) of MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	33-58	cadherin 5	Homo sapiens	100-111
24391778-4	2013	We first examined whether MBL modulated heat-killed (HK) C. albicans-induced cellular responses in phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 macrophages.	Tetradecanoylphorbol Acetate	99-130	GLI family zinc finger 2	Homo sapiens	153-158
24391778-4	2013	We first examined whether MBL modulated heat-killed (HK) C. albicans-induced cellular responses in phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 macrophages.	Tetradecanoylphorbol Acetate	132-135	GLI family zinc finger 2	Homo sapiens	153-158
24211779-6	2013	Treatment of HUVECs with H2O2 or phorbol myristate acetate (PMA) led to tyrosine phosphorylation of VE-cadherin, dissociation of beta-catenin from VE-cadherin complex and increased transendothelial migration (TEM) of MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	33-58	cadherin 5	Homo sapiens	147-158
24211779-6	2013	Treatment of HUVECs with H2O2 or phorbol myristate acetate (PMA) led to tyrosine phosphorylation of VE-cadherin, dissociation of beta-catenin from VE-cadherin complex and increased transendothelial migration (TEM) of MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	60-63	cadherin 5	Homo sapiens	100-111
24211779-6	2013	Treatment of HUVECs with H2O2 or phorbol myristate acetate (PMA) led to tyrosine phosphorylation of VE-cadherin, dissociation of beta-catenin from VE-cadherin complex and increased transendothelial migration (TEM) of MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	60-63	cadherin 5	Homo sapiens	147-158
23748245-5	2013	RT-PCR and Western blotting experiments demonstrated the expression of uPAR in phorbol 12-myristate 13-acetate (PMA)-stimulated dental epithelial cells (HAT-7 cells).	Tetradecanoylphorbol Acetate	79-110	plasminogen activator, urokinase receptor	Rattus norvegicus	71-75
24403255-4	2013	Indeed, IL-13(-/-) mice developed more papillomas after exposure to DMBA/TPA than their heterozygous IL-13-competent littermate controls.	Tetradecanoylphorbol Acetate	73-76	interleukin 13	Mus musculus	8-13
24403255-7	2013	Conversely, IL-13 does not affect MCA carcinogenesis but protects mice from DMBA/TPA carcinogenesis.	Tetradecanoylphorbol Acetate	81-84	interleukin 13	Mus musculus	12-17
24403255-9	2013	Taken together, our results indicate that the course of DMBA/TPA- and MCA-induced carcinogenesis is affected differently by IL-4 versus IL-13-mediated inflammatory cascades.	Tetradecanoylphorbol Acetate	61-64	interleukin 13	Mus musculus	136-141
23748245-5	2013	RT-PCR and Western blotting experiments demonstrated the expression of uPAR in phorbol 12-myristate 13-acetate (PMA)-stimulated dental epithelial cells (HAT-7 cells).	Tetradecanoylphorbol Acetate	112-115	plasminogen activator, urokinase receptor	Rattus norvegicus	71-75
23954399-4	2013	Overexpression of the larger isoform of ZXDC, ZXDC1, activates expression of monocyte-specific markers of differentiation and synergizes with phorbol 12-myristate 13-acetate (which causes differentiation) in the human leukemic monoblast cell line U937.	Tetradecanoylphorbol Acetate	142-173	ZXD family zinc finger C	Homo sapiens	40-44
23943124-6	2013	In whole-cell patch clamp experiments, TRPM2 currents in the DRG incubated with PMA were stimulated by H2O2.	Tetradecanoylphorbol Acetate	80-83	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	39-44
23943124-7	2013	In addition, the PMA-induced activation of TRPM2 channels were blocked by nonspecific TRPM2 channels inhibitors [2-aminoethyl diphenylborinate (2-APB) and N-(p-amylcinnamoyl)anthranilic acid (ACA)].	Tetradecanoylphorbol Acetate	17-20	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	43-48
23943124-7	2013	In addition, the PMA-induced activation of TRPM2 channels were blocked by nonspecific TRPM2 channels inhibitors [2-aminoethyl diphenylborinate (2-APB) and N-(p-amylcinnamoyl)anthranilic acid (ACA)].	Tetradecanoylphorbol Acetate	17-20	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	86-91
23740089-3	2013	Our results showed that when differentiated HL-60 (dHL-60) cells were primed with TNF-alpha for 10 min, ROS production induced by zymosan A or phorbol myristate acetate (PMA) was enhanced in a TNF-alpha-dose-dependent manner.	Tetradecanoylphorbol Acetate	143-168	tumor necrosis factor	Homo sapiens	82-91
23740089-3	2013	Our results showed that when differentiated HL-60 (dHL-60) cells were primed with TNF-alpha for 10 min, ROS production induced by zymosan A or phorbol myristate acetate (PMA) was enhanced in a TNF-alpha-dose-dependent manner.	Tetradecanoylphorbol Acetate	143-168	tumor necrosis factor	Homo sapiens	193-202
23740089-3	2013	Our results showed that when differentiated HL-60 (dHL-60) cells were primed with TNF-alpha for 10 min, ROS production induced by zymosan A or phorbol myristate acetate (PMA) was enhanced in a TNF-alpha-dose-dependent manner.	Tetradecanoylphorbol Acetate	170-173	tumor necrosis factor	Homo sapiens	82-91
23740089-3	2013	Our results showed that when differentiated HL-60 (dHL-60) cells were primed with TNF-alpha for 10 min, ROS production induced by zymosan A or phorbol myristate acetate (PMA) was enhanced in a TNF-alpha-dose-dependent manner.	Tetradecanoylphorbol Acetate	170-173	tumor necrosis factor	Homo sapiens	193-202
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	277-280	protein kinase C alpha	Homo sapiens	167-175
24191027-7	2013	Lastly, blocking the proteosomal degradation of MCPIP1 by MG132 abrogated HIV-1 production in phorbol 12-myristate 13-acetate/ionomycin-stimulated human CD4+ T cells isolated from healthy donors.	Tetradecanoylphorbol Acetate	94-125	CD4 molecule	Homo sapiens	153-156
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	82-107	protein kinase C alpha	Homo sapiens	33-36
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	82-107	protein kinase C alpha	Homo sapiens	73-76
24048413-8	2013	Clots generated with thrombin in FGN-Perth plasma were resistant to tPA-mediated fibrinolysis.	Tetradecanoylphorbol Acetate	68-71	coagulation factor II, thrombin	Homo sapiens	21-29
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	82-107	protein kinase C alpha	Homo sapiens	167-175
23937324-6	2013	Moreover, using a yeast-based assay previously developed for the screening of PKC inhibitors, it was also shown that, like the known PKC inhibitor NPC 15437, ceramide reduced the PMA-induced growth inhibition, supporting an inhibitory effect of ceramide on PKCdelta.	Tetradecanoylphorbol Acetate	179-182	protein kinase C alpha	Homo sapiens	78-81
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	82-107	protein kinase C alpha	Homo sapiens	73-76
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	82-107	protein kinase C alpha	Homo sapiens	167-175
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	109-112	protein kinase C alpha	Homo sapiens	33-36
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	109-112	protein kinase C alpha	Homo sapiens	73-76
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	109-112	protein kinase C alpha	Homo sapiens	167-175
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	109-112	protein kinase C alpha	Homo sapiens	73-76
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	109-112	protein kinase C alpha	Homo sapiens	167-175
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	277-280	protein kinase C alpha	Homo sapiens	33-36
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	277-280	protein kinase C alpha	Homo sapiens	136-144
24260363-4	2013	Here, we showed that interfering PKC expression by chronic activation of PKC with phorbol myristate acetate (PMA) or shRNA targeting at PKCalpha lowered the levels of PKCalpha in cytosol, peripheral membrane and integral membrane pools, while short-term activation of PKC with PMA induced accumulation of PKCalpha in the membrane pool accompanied by a dramatic decrease in the cytosol fraction.	Tetradecanoylphorbol Acetate	277-280	protein kinase C alpha	Homo sapiens	167-175
23929882-4	2013	Phorbol 12-myristate 13-acetate (PMA), but not adenosine diphosphate (ADP), induced binding of FN to platelets in suspension.	Tetradecanoylphorbol Acetate	0-31	fibronectin 1	Homo sapiens	95-97
23929882-4	2013	Phorbol 12-myristate 13-acetate (PMA), but not adenosine diphosphate (ADP), induced binding of FN to platelets in suspension.	Tetradecanoylphorbol Acetate	33-36	fibronectin 1	Homo sapiens	95-97
23933110-0	2013	Luteolin 8-C-beta-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-kappaB signaling in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
23933110-0	2013	Luteolin 8-C-beta-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-kappaB signaling in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	66-69	mitogen-activated protein kinase 1	Homo sapiens	97-100
23933110-0	2013	Luteolin 8-C-beta-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-kappaB signaling in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	66-69	mitogen-activated protein kinase 1	Homo sapiens	110-113
23933110-3	2013	We investigated whether LU8C-FP would inhibit MMP-9 activation and IL-8 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
23933110-4	2013	LU8C-FP suppressed TPA-induced MMP-9 and IL-8 secretion and mRNA expression via inhibition of the MAPK signaling pathway and down-regulation of nuclear AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
23933110-4	2013	LU8C-FP suppressed TPA-induced MMP-9 and IL-8 secretion and mRNA expression via inhibition of the MAPK signaling pathway and down-regulation of nuclear AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase 3	Homo sapiens	98-102
23933110-5	2013	TPA-induced phosphorylation of ERK 1/2 was suppressed by LU8C-FP, whereas JNK and p38 MAPK phosphorylation were unaffected.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	31-38
24035999-8	2013	Real-time imaging in MIN6 cells expressing green fluorescent protein-tagged DGKalpha or DGKgamma showed that the DGK activator phorbol 12-myristate 13-acetate rapidly induced translocation of DGKgamma to the plasma membrane, whereas high K(+) slowly translocated DGKalpha and DGKgamma to the plasma membrane.	Tetradecanoylphorbol Acetate	127-158	diacylglycerol kinase, alpha	Mus musculus	76-96
23937324-6	2013	Moreover, using a yeast-based assay previously developed for the screening of PKC inhibitors, it was also shown that, like the known PKC inhibitor NPC 15437, ceramide reduced the PMA-induced growth inhibition, supporting an inhibitory effect of ceramide on PKCdelta.	Tetradecanoylphorbol Acetate	179-182	protein kinase C alpha	Homo sapiens	133-136
24008507-7	2013	Similar to the inhibitory effects shown in MDA-MB-231 cells, we observed that DSW treatment resulted in the inhibition of TPA-induced migration and MMP-9 activity with a concomitant decrease in mRNA levels of MMP-9, TGF-beta, Wnt5a and Wnt3a.	Tetradecanoylphorbol Acetate	122-125	transforming growth factor beta 1	Homo sapiens	216-224
24008507-7	2013	Similar to the inhibitory effects shown in MDA-MB-231 cells, we observed that DSW treatment resulted in the inhibition of TPA-induced migration and MMP-9 activity with a concomitant decrease in mRNA levels of MMP-9, TGF-beta, Wnt5a and Wnt3a.	Tetradecanoylphorbol Acetate	122-125	Wnt family member 5A	Homo sapiens	226-231
23657563-8	2013	To ascertain the role of NF-kappaB activation in the altered expression of ET-1 and eNOS, we treated HUVECs with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	113-144	endothelin 1	Homo sapiens	75-88
24135872-5	2013	The spectacular change in phenotype induced by TPA, leading to a pronounced spindle-shaped fibroblast-like cell morphology, required ERK1/2 activation.	Tetradecanoylphorbol Acetate	47-50	mitogen-activated protein kinase 3	Homo sapiens	133-139
24135872-8	2013	We found that TPA triggered the formation of a complex between Snail and beta-catenin that activated the Wnt pathway.	Tetradecanoylphorbol Acetate	14-17	snail family transcriptional repressor 1	Homo sapiens	63-68
23657563-8	2013	To ascertain the role of NF-kappaB activation in the altered expression of ET-1 and eNOS, we treated HUVECs with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	146-149	endothelin 1	Homo sapiens	75-88
23900299-0	2013	Triptolide induces apoptosis of PMA-treated THP-1 cells through activation of caspases, inhibition of NF-kappaB and activation of MAPKs.	Tetradecanoylphorbol Acetate	32-35	nuclear factor kappa B subunit 1	Homo sapiens	102-111
23888334-3	2013	A2 also showed a stronger inhibitory effect than curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in NF-kappaB activation and IL-1beta expression as well as in aldose reductase activity.	Tetradecanoylphorbol Acetate	61-97	interleukin 1 beta	Mus musculus	150-158
23888334-5	2013	In vivo studies indicated that A2 was more potent than curcumin for inhibiting TPA-induced ear edema and TPA-induced increases in IL-1beta.	Tetradecanoylphorbol Acetate	105-108	interleukin 1 beta	Mus musculus	130-138
23957209-1	2013	UNLABELLED: Superoxide production by Nox1, a member of the Nox family NAPDH oxidases, requires expression of its regulatory soluble proteins Noxo1 (Nox organizer 1) and Noxa1 (Nox activator 1) and is markedly enhanced upon cell stimulation with phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	245-276	NADPH oxidase activator 1	Homo sapiens	169-174
23957209-1	2013	UNLABELLED: Superoxide production by Nox1, a member of the Nox family NAPDH oxidases, requires expression of its regulatory soluble proteins Noxo1 (Nox organizer 1) and Noxa1 (Nox activator 1) and is markedly enhanced upon cell stimulation with phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	245-276	NADPH oxidase activator 1	Homo sapiens	176-191
23421558-12	2013	In all patients, the interferon-gamma response of T lymphocytes to phorbolmyristate acetate-ionomycin was higher compared with normal donors, but it was further increased after tumor ablation only in prostate cancer patients.	Tetradecanoylphorbol Acetate	67-91	interferon gamma	Homo sapiens	21-37
23884236-8	2013	In addition, treatment with ESM resulted in a reduction of PMA-stimulated phosphorylation of p38, extracellular regulated kinases (ERK) 1/2, and c-Jun N-terminal kinase (JNK).	Tetradecanoylphorbol Acetate	59-62	mitogen-activated protein kinase 1	Homo sapiens	93-96
23884236-8	2013	In addition, treatment with ESM resulted in a reduction of PMA-stimulated phosphorylation of p38, extracellular regulated kinases (ERK) 1/2, and c-Jun N-terminal kinase (JNK).	Tetradecanoylphorbol Acetate	59-62	mitogen-activated protein kinase 3	Homo sapiens	98-139
23884236-8	2013	In addition, treatment with ESM resulted in a reduction of PMA-stimulated phosphorylation of p38, extracellular regulated kinases (ERK) 1/2, and c-Jun N-terminal kinase (JNK).	Tetradecanoylphorbol Acetate	59-62	mitogen-activated protein kinase 8	Homo sapiens	145-168
23884236-8	2013	In addition, treatment with ESM resulted in a reduction of PMA-stimulated phosphorylation of p38, extracellular regulated kinases (ERK) 1/2, and c-Jun N-terminal kinase (JNK).	Tetradecanoylphorbol Acetate	59-62	mitogen-activated protein kinase 8	Homo sapiens	170-173
23594597-4	2013	Using mice harboring a keratinocyte-specific deletion of RAGE, we analyzed its role in the regulation of an acute inflammatory response that was induced by topical treatment of the back skin with the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	214-251	advanced glycosylation end product-specific receptor	Mus musculus	57-61
23594597-6	2013	To address the underlying molecular mechanism, we isolated interfollicular epidermis by laser microdissection for gene expression analysis, and identified RAGE as a regulator in the temporal control of TPA-induced epidermal tumor necrosis factor alpha transcript levels.	Tetradecanoylphorbol Acetate	202-205	advanced glycosylation end product-specific receptor	Mus musculus	155-159
23594597-6	2013	To address the underlying molecular mechanism, we isolated interfollicular epidermis by laser microdissection for gene expression analysis, and identified RAGE as a regulator in the temporal control of TPA-induced epidermal tumor necrosis factor alpha transcript levels.	Tetradecanoylphorbol Acetate	202-205	tumor necrosis factor	Mus musculus	224-251
23911786-4	2013	TQ diminished nuclear translocation and the DNA binding of nuclear factor-kappaB (NF-kappaB) via the blockade of phosphorylation and subsequent degradation of IkappaBalpha in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	175-178	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	59-80
24065532-4	2013	Also, transcription of TPA-induced cyclooxygenase-2 (COX-2), which enhances breast cancer progression and metastasis via the increase of prostaglandin E2 biosynthesis, was downregulated by the PS in a dose-dependent manner.	Tetradecanoylphorbol Acetate	23-26	prostaglandin-endoperoxide synthase 2	Homo sapiens	35-51
24065532-4	2013	Also, transcription of TPA-induced cyclooxygenase-2 (COX-2), which enhances breast cancer progression and metastasis via the increase of prostaglandin E2 biosynthesis, was downregulated by the PS in a dose-dependent manner.	Tetradecanoylphorbol Acetate	23-26	prostaglandin-endoperoxide synthase 2	Homo sapiens	53-58
23900581-8	2013	In addition, the knockdown of JNK-1 expression by siRNA-JNK-1 or siRNA-JNK-2 significantly impaired the upregulation of AP-1 luciferase reporter gene, but failed to decrease the levels of AP-1 reporter gene expression induced by TPA treatment.	Tetradecanoylphorbol Acetate	229-232	mitogen-activated protein kinase 8	Homo sapiens	30-35
24058654-7	2013	THP-1 monocytes were transformed into macrophages by 48h incubation with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	73-104	GLI family zinc finger 2	Homo sapiens	0-5
24053256-7	2013	Treatment of STE on TPA-induced HONE-1 cells inhibited MMP-9 expression and ERK1/2 phosphorylation without affecting JNK and p38 phosphorylation.	Tetradecanoylphorbol Acetate	20-23	mitogen-activated protein kinase 3	Homo sapiens	76-82
23911786-4	2013	TQ diminished nuclear translocation and the DNA binding of nuclear factor-kappaB (NF-kappaB) via the blockade of phosphorylation and subsequent degradation of IkappaBalpha in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	175-178	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	82-91
23911786-4	2013	TQ diminished nuclear translocation and the DNA binding of nuclear factor-kappaB (NF-kappaB) via the blockade of phosphorylation and subsequent degradation of IkappaBalpha in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	175-178	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	159-171
23911786-7	2013	Taken together, the inhibitory effects of TQ on TPA-induced COX-2 expression and NF-kappaB activation, and its ability to induce the expression of cytoprotective proteins provide a mechanistic basis of anti-inflammatory and antioxidative effects of TQ in hairless mouse skin.	Tetradecanoylphorbol Acetate	48-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	81-90
23566359-9	2013	Pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) were also reduced significantly in a dose dependent manner in all the TPA treated groups as compared to control.	Tetradecanoylphorbol Acetate	128-131	interleukin 1 beta	Mus musculus	28-36
23774438-5	2013	Treatment of MHV68-infected mice with neuroserpin, a mammalian serpin that inhibits only tPA and uPA, was ineffective.	Tetradecanoylphorbol Acetate	89-92	serine (or cysteine) peptidase inhibitor, clade I, member 1	Mus musculus	38-49
23804203-5	2013	In contrast, activation of PKC with phorbol 12-myristate 13-acetate mimicked the inhibitory effect of REV on K(v)2.2 by modifying the activation or inactivation properties of Kv2.2 channels and eliminated any further inhibition by REV.	Tetradecanoylphorbol Acetate	36-67	protein kinase C alpha	Homo sapiens	27-30
24152593-9	2013	Although expression of BIGH3 did not alter actin polymerization in response to CXCL12, it inhibited the PMA-induced activation of the small GTPase RAC1 as well as the phosphorylation and activation of extracellular-regulated kinases (ERKs).	Tetradecanoylphorbol Acetate	104-107	mitogen-activated protein kinase 1	Homo sapiens	234-238
23566359-9	2013	Pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) were also reduced significantly in a dose dependent manner in all the TPA treated groups as compared to control.	Tetradecanoylphorbol Acetate	128-131	interleukin 6	Mus musculus	38-42
23566359-9	2013	Pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) were also reduced significantly in a dose dependent manner in all the TPA treated groups as compared to control.	Tetradecanoylphorbol Acetate	128-131	tumor necrosis factor	Mus musculus	47-56
24089228-13	2013	It was noteworthy that the ERK activator (phorbol 12-myristate 13-acetate [PMA]) treatment increased the MMP-9/VEGF levels after propofol treatment, and led to significant increase of proliferation, invasion and angiogenesis.	Tetradecanoylphorbol Acetate	42-73	mitogen-activated protein kinase 1	Homo sapiens	27-30
24089228-13	2013	It was noteworthy that the ERK activator (phorbol 12-myristate 13-acetate [PMA]) treatment increased the MMP-9/VEGF levels after propofol treatment, and led to significant increase of proliferation, invasion and angiogenesis.	Tetradecanoylphorbol Acetate	42-73	vascular endothelial growth factor A	Homo sapiens	111-115
24089228-13	2013	It was noteworthy that the ERK activator (phorbol 12-myristate 13-acetate [PMA]) treatment increased the MMP-9/VEGF levels after propofol treatment, and led to significant increase of proliferation, invasion and angiogenesis.	Tetradecanoylphorbol Acetate	75-78	mitogen-activated protein kinase 1	Homo sapiens	27-30
24089228-13	2013	It was noteworthy that the ERK activator (phorbol 12-myristate 13-acetate [PMA]) treatment increased the MMP-9/VEGF levels after propofol treatment, and led to significant increase of proliferation, invasion and angiogenesis.	Tetradecanoylphorbol Acetate	75-78	vascular endothelial growth factor A	Homo sapiens	111-115
23774263-8	2013	In addition, RA reduced PMA-stimulated phosphorylation of p38, extracellular regulated kinases (ERK) 1/2, and c-Jun N-terminal kinase (JNK).	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 1	Homo sapiens	58-61
23774263-8	2013	In addition, RA reduced PMA-stimulated phosphorylation of p38, extracellular regulated kinases (ERK) 1/2, and c-Jun N-terminal kinase (JNK).	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 3	Homo sapiens	63-104
23774263-8	2013	In addition, RA reduced PMA-stimulated phosphorylation of p38, extracellular regulated kinases (ERK) 1/2, and c-Jun N-terminal kinase (JNK).	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 8	Homo sapiens	110-133
23774263-8	2013	In addition, RA reduced PMA-stimulated phosphorylation of p38, extracellular regulated kinases (ERK) 1/2, and c-Jun N-terminal kinase (JNK).	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 8	Homo sapiens	135-138
23939428-2	2013	Previous studies have shown PPARgamma has cytoplasmic activities upon tetradecanoyl phorbol acetate (TPA) stimulation.	Tetradecanoylphorbol Acetate	70-99	peroxisome proliferator activated receptor gamma	Homo sapiens	28-37
23835587-9	2013	DMBA/TPA treatment also strongly increased mRNA levels of inflammation markers COX-2 and IL-6.	Tetradecanoylphorbol Acetate	5-8	interleukin 6	Mus musculus	89-93
23833248-8	2013	However, while pharmacological inhibition of PKC suppressed PMA-induced activation of MEK-ERK-IKK signaling, activation by palmitate was upheld, suggesting that DAG-sensitive PKC and RKIP were dispensable for palmitate"s proinflammatory action.	Tetradecanoylphorbol Acetate	60-63	mitogen-activated protein kinase kinase 7	Homo sapiens	86-89
23833248-8	2013	However, while pharmacological inhibition of PKC suppressed PMA-induced activation of MEK-ERK-IKK signaling, activation by palmitate was upheld, suggesting that DAG-sensitive PKC and RKIP were dispensable for palmitate"s proinflammatory action.	Tetradecanoylphorbol Acetate	60-63	mitogen-activated protein kinase 1	Homo sapiens	90-93
23386263-6	2013	BDMC reduced oxLDL uptake most effectively, while CUR was the best inhibitor for CD36, scavenger receptor A, and lectin-like oxidized LDL receptor-1 expression during phorbol 12-myristate 13-acetate (PMA)-induced THP-1 differentiation.	Tetradecanoylphorbol Acetate	167-198	GLI family zinc finger 2	Homo sapiens	213-218
23775412-5	2013	The expression of PAR4 in cultured DRG neurons was also assessed after treatment with IL-1beta with pre-addition of phorbol-12-myristate 13-acetate (PMA, a PKC activator) or chelerythrine chloride (a PKC inhibitor).	Tetradecanoylphorbol Acetate	116-147	interleukin 1 beta	Rattus norvegicus	86-94
23775412-8	2013	This IL-1beta effect was enhanced in DRG neurons when DRG cultures were pre-treatment with the PMA.	Tetradecanoylphorbol Acetate	95-98	interleukin 1 beta	Rattus norvegicus	5-13
23814099-4	2013	We observed that the phosphorylation of C/EBPalpha Ser-21 was inhibited by a PKCdelta-specific inhibitor, rottlerin, or IL-32beta knockdown by siRNA and that IL-32beta shifted to the membrane from the cytosol upon phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	214-245	CCAAT enhancer binding protein alpha	Homo sapiens	40-50
23977008-11	2013	The protein kinase C (PKC) inhibitor and the MAPK/ERK kinase (MEK) inhibitor significantly blocked the potentiation of PMA-mediated KLF6 induction and the down-regulation of PTTG1, indicating that PTTG1 is suppressed via the activation of PKC/ERK/KLF6 pathway.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 1	Homo sapiens	45-49
23977008-11	2013	The protein kinase C (PKC) inhibitor and the MAPK/ERK kinase (MEK) inhibitor significantly blocked the potentiation of PMA-mediated KLF6 induction and the down-regulation of PTTG1, indicating that PTTG1 is suppressed via the activation of PKC/ERK/KLF6 pathway.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 1	Homo sapiens	50-53
23977008-11	2013	The protein kinase C (PKC) inhibitor and the MAPK/ERK kinase (MEK) inhibitor significantly blocked the potentiation of PMA-mediated KLF6 induction and the down-regulation of PTTG1, indicating that PTTG1 is suppressed via the activation of PKC/ERK/KLF6 pathway.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 1	Homo sapiens	243-246
23939428-2	2013	Previous studies have shown PPARgamma has cytoplasmic activities upon tetradecanoyl phorbol acetate (TPA) stimulation.	Tetradecanoylphorbol Acetate	101-104	peroxisome proliferator activated receptor gamma	Homo sapiens	28-37
23939428-10	2013	Using RNA interference technology, we also found that down-regulated Skp2 reduced the phosphorylation level of MEK1 and significantly reversed TPA-induced nuclear export of PPARgamma in MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	143-146	peroxisome proliferator activated receptor gamma	Homo sapiens	173-182
23648122-8	2013	Conditioned media of five ESCC cell lines (TE-8, -9, -10, -11 and -15) induced mRNA as well as protein expression of CD204 but not of CD163 with upregulation of vascular endothelial growth factor-A mRNA in TPA treated human acute monocytic leukemia cell line THP-1.	Tetradecanoylphorbol Acetate	206-209	vascular endothelial growth factor A	Homo sapiens	161-197
23940799-7	2013	Fisetin suppressed the TPA (tetradecanoylphorbol-13-acetate)-induced activation of p38 MAPK and uPA, and inhibited the TPA-enhanced migratory and invasive abilities.	Tetradecanoylphorbol Acetate	23-26	mitogen-activated protein kinase 1	Homo sapiens	83-86
23940799-7	2013	Fisetin suppressed the TPA (tetradecanoylphorbol-13-acetate)-induced activation of p38 MAPK and uPA, and inhibited the TPA-enhanced migratory and invasive abilities.	Tetradecanoylphorbol Acetate	23-26	mitogen-activated protein kinase 3	Homo sapiens	87-91
23940799-7	2013	Fisetin suppressed the TPA (tetradecanoylphorbol-13-acetate)-induced activation of p38 MAPK and uPA, and inhibited the TPA-enhanced migratory and invasive abilities.	Tetradecanoylphorbol Acetate	23-26	plasminogen activator, urokinase	Homo sapiens	96-99
23488970-10	2013	Lower concentration PMA (100 nM) replicated the major effects of EtOH, while higher concentration PMA (1 muM) did not, suggesting that the EtOH effects operate through activation of PKC and were mimicked by lower concentration of PMA.	Tetradecanoylphorbol Acetate	98-101	latexin	Homo sapiens	105-108
23488970-10	2013	Lower concentration PMA (100 nM) replicated the major effects of EtOH, while higher concentration PMA (1 muM) did not, suggesting that the EtOH effects operate through activation of PKC and were mimicked by lower concentration of PMA.	Tetradecanoylphorbol Acetate	98-101	latexin	Homo sapiens	105-108
23562609-4	2013	METHODS: SIRPalpha was induced in SIRPalpha-negative promyelocytic cells by retinoic acid or phorbol 12-myristate 13-acetate, and the differential expression of miRNAs was assessed by means of microarray and quantitative RT-PCR assays.	Tetradecanoylphorbol Acetate	93-124	signal regulatory protein alpha	Homo sapiens	9-18
23615401-9	2013	Furthermore, TPA-induced extracellular signal-regulated kinase (ERK) 1/2 and Akt phosphorylation and the DNA binding activity of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) were attenuated by pretreatment with AP and HO-1 end products.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 3	Homo sapiens	25-72
23615401-9	2013	Furthermore, TPA-induced extracellular signal-regulated kinase (ERK) 1/2 and Akt phosphorylation and the DNA binding activity of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) were attenuated by pretreatment with AP and HO-1 end products.	Tetradecanoylphorbol Acetate	13-16	AKT serine/threonine kinase 1	Homo sapiens	77-80
23615401-9	2013	Furthermore, TPA-induced extracellular signal-regulated kinase (ERK) 1/2 and Akt phosphorylation and the DNA binding activity of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) were attenuated by pretreatment with AP and HO-1 end products.	Tetradecanoylphorbol Acetate	13-16	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	129-148
23615401-9	2013	Furthermore, TPA-induced extracellular signal-regulated kinase (ERK) 1/2 and Akt phosphorylation and the DNA binding activity of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) were attenuated by pretreatment with AP and HO-1 end products.	Tetradecanoylphorbol Acetate	13-16	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	150-154
23615401-9	2013	Furthermore, TPA-induced extracellular signal-regulated kinase (ERK) 1/2 and Akt phosphorylation and the DNA binding activity of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) were attenuated by pretreatment with AP and HO-1 end products.	Tetradecanoylphorbol Acetate	13-16	nuclear factor kappa B subunit 1	Homo sapiens	160-182
23615401-9	2013	Furthermore, TPA-induced extracellular signal-regulated kinase (ERK) 1/2 and Akt phosphorylation and the DNA binding activity of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) were attenuated by pretreatment with AP and HO-1 end products.	Tetradecanoylphorbol Acetate	13-16	nuclear factor kappa B subunit 1	Homo sapiens	184-193
23615401-10	2013	In conclusion, these results suggest that AP inhibits TPA-induced cell migration and invasion by reducing MMP-9 activation, which is mediated mainly by inhibition of the ERK1/2 and phosphatidylinositol 3-kinase/Akt signaling pathways and subsequent AP-1 and NF-kappaB transactivation.	Tetradecanoylphorbol Acetate	54-57	mitogen-activated protein kinase 3	Homo sapiens	170-176
23615401-10	2013	In conclusion, these results suggest that AP inhibits TPA-induced cell migration and invasion by reducing MMP-9 activation, which is mediated mainly by inhibition of the ERK1/2 and phosphatidylinositol 3-kinase/Akt signaling pathways and subsequent AP-1 and NF-kappaB transactivation.	Tetradecanoylphorbol Acetate	54-57	AKT serine/threonine kinase 1	Homo sapiens	211-214
23615401-10	2013	In conclusion, these results suggest that AP inhibits TPA-induced cell migration and invasion by reducing MMP-9 activation, which is mediated mainly by inhibition of the ERK1/2 and phosphatidylinositol 3-kinase/Akt signaling pathways and subsequent AP-1 and NF-kappaB transactivation.	Tetradecanoylphorbol Acetate	54-57	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	249-253
23615401-10	2013	In conclusion, these results suggest that AP inhibits TPA-induced cell migration and invasion by reducing MMP-9 activation, which is mediated mainly by inhibition of the ERK1/2 and phosphatidylinositol 3-kinase/Akt signaling pathways and subsequent AP-1 and NF-kappaB transactivation.	Tetradecanoylphorbol Acetate	54-57	nuclear factor kappa B subunit 1	Homo sapiens	258-267
23602908-2	2013	We previously showed the significant reduction or induction of EC-SOD during human monocytic U937 or THP-1 cell differentiation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), respectively; however, its cell-specific expression and regulation have not been fully elucidated.	Tetradecanoylphorbol Acetate	139-175	superoxide dismutase 3	Homo sapiens	63-69
23602908-2	2013	We previously showed the significant reduction or induction of EC-SOD during human monocytic U937 or THP-1 cell differentiation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), respectively; however, its cell-specific expression and regulation have not been fully elucidated.	Tetradecanoylphorbol Acetate	177-180	superoxide dismutase 3	Homo sapiens	63-69
23602908-5	2013	Moreover, treatment with a DNA methyltransferase inhibitor, 5-azacytidine, significantly induced the expression of EC-SOD in THP-1 cells, indicating the importance of DNA methylation in the suppression of EC-SOD expression; however, the DNA methylation status did not change during THP-1 cell differentiation induced by TPA.	Tetradecanoylphorbol Acetate	320-323	superoxide dismutase 3	Homo sapiens	115-121
23602908-7	2013	Further, pretreatment with histone acetyltransferase inhibitors, CPTH2 or garcinol, significantly suppressed the TPA-inducible EC-SOD expression.	Tetradecanoylphorbol Acetate	113-116	superoxide dismutase 3	Homo sapiens	127-133
23602908-10	2013	Overall, these findings provide novel evidence that cell-specific and TPA-inducible EC-SOD expression are regulated by DNA methylation and histone H3 and H4 acetylation in human monocytic cells.	Tetradecanoylphorbol Acetate	70-73	superoxide dismutase 3	Homo sapiens	84-90
23562609-7	2013	During SIRPalpha induction, levels of these 3 miRNAs were all reduced, and their downregulation by retinoic acid or phorbol 12-myristate 13-acetate occurred through suppression of the c-Myc signaling pathway.	Tetradecanoylphorbol Acetate	116-147	signal regulatory protein alpha	Homo sapiens	7-16
23660295-6	2013	When stimulated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or CD437, this TR3-TRAPgamma interaction not only induced Ca(2+) depletion in the endoplasmic reticulum (ER) but also promoted the expression of the proapoptotic transcriptional regulator CHOP.	Tetradecanoylphorbol Acetate	21-57	nuclear receptor subfamily 4 group A member 1	Homo sapiens	79-82
23660295-6	2013	When stimulated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or CD437, this TR3-TRAPgamma interaction not only induced Ca(2+) depletion in the endoplasmic reticulum (ER) but also promoted the expression of the proapoptotic transcriptional regulator CHOP.	Tetradecanoylphorbol Acetate	21-57	DNA damage inducible transcript 3	Homo sapiens	252-256
23660295-6	2013	When stimulated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or CD437, this TR3-TRAPgamma interaction not only induced Ca(2+) depletion in the endoplasmic reticulum (ER) but also promoted the expression of the proapoptotic transcriptional regulator CHOP.	Tetradecanoylphorbol Acetate	59-62	nuclear receptor subfamily 4 group A member 1	Homo sapiens	79-82
23660295-6	2013	When stimulated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or CD437, this TR3-TRAPgamma interaction not only induced Ca(2+) depletion in the endoplasmic reticulum (ER) but also promoted the expression of the proapoptotic transcriptional regulator CHOP.	Tetradecanoylphorbol Acetate	59-62	DNA damage inducible transcript 3	Homo sapiens	252-256
23904362-4	2013	The lipopolysaccharide (LPS)-stimulated phrobol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophage models were established.	Tetradecanoylphorbol Acetate	73-76	GLI family zinc finger 2	Homo sapiens	93-98
23664529-8	2013	By BANF1 knockdown in TPA-stimulated HSC-1 cells, the mRNA levels of S100A9 were significantly elevated compared with those of control HSC-1 cells treated with siRNA to CD4.	Tetradecanoylphorbol Acetate	22-25	BAF nuclear assembly factor 1	Homo sapiens	3-8
23664529-8	2013	By BANF1 knockdown in TPA-stimulated HSC-1 cells, the mRNA levels of S100A9 were significantly elevated compared with those of control HSC-1 cells treated with siRNA to CD4.	Tetradecanoylphorbol Acetate	22-25	CD4 molecule	Homo sapiens	169-172
23764888-5	2013	Arazyme inhibited the secretion of IL-6 and IL-8 due to phorbol 12-myristate 13-acetate and calcium ionophores in human mast cells.	Tetradecanoylphorbol Acetate	56-87	interleukin 6	Homo sapiens	35-39
23775122-2	2013	PKC activation by phorbol ester (phorbol myristate acetate [PMA]) reduced insulin-induced p-Tyr-IRS2 by 46% +- 13% and, similarly, phosphorylation of Akt/eNOS.	Tetradecanoylphorbol Acetate	33-58	insulin	Cricetulus griseus	74-81
23775122-2	2013	PKC activation by phorbol ester (phorbol myristate acetate [PMA]) reduced insulin-induced p-Tyr-IRS2 by 46% +- 13% and, similarly, phosphorylation of Akt/eNOS.	Tetradecanoylphorbol Acetate	33-58	AKT serine/threonine kinase 1	Rattus norvegicus	150-153
23775122-2	2013	PKC activation by phorbol ester (phorbol myristate acetate [PMA]) reduced insulin-induced p-Tyr-IRS2 by 46% +- 13% and, similarly, phosphorylation of Akt/eNOS.	Tetradecanoylphorbol Acetate	60-63	insulin	Cricetulus griseus	74-81
23775122-2	2013	PKC activation by phorbol ester (phorbol myristate acetate [PMA]) reduced insulin-induced p-Tyr-IRS2 by 46% +- 13% and, similarly, phosphorylation of Akt/eNOS.	Tetradecanoylphorbol Acetate	60-63	AKT serine/threonine kinase 1	Rattus norvegicus	150-153
23775122-3	2013	Site-specific mutational analysis showed that PMA increased serine phosphorylation at three sites on IRS2 (positions 303, 343, and 675), which affected insulin-induced tyrosine phosphorylation of IRS2 at positions 653, 671, and 911 (p-Tyr-IRS2) and p-Akt/eNOS.	Tetradecanoylphorbol Acetate	46-49	insulin receptor substrate 2	Rattus norvegicus	101-105
23775122-3	2013	Site-specific mutational analysis showed that PMA increased serine phosphorylation at three sites on IRS2 (positions 303, 343, and 675), which affected insulin-induced tyrosine phosphorylation of IRS2 at positions 653, 671, and 911 (p-Tyr-IRS2) and p-Akt/eNOS.	Tetradecanoylphorbol Acetate	46-49	insulin	Cricetulus griseus	152-159
23775122-3	2013	Site-specific mutational analysis showed that PMA increased serine phosphorylation at three sites on IRS2 (positions 303, 343, and 675), which affected insulin-induced tyrosine phosphorylation of IRS2 at positions 653, 671, and 911 (p-Tyr-IRS2) and p-Akt/eNOS.	Tetradecanoylphorbol Acetate	46-49	insulin receptor substrate 2	Rattus norvegicus	196-200
23775122-3	2013	Site-specific mutational analysis showed that PMA increased serine phosphorylation at three sites on IRS2 (positions 303, 343, and 675), which affected insulin-induced tyrosine phosphorylation of IRS2 at positions 653, 671, and 911 (p-Tyr-IRS2) and p-Akt/eNOS.	Tetradecanoylphorbol Acetate	46-49	insulin receptor substrate 2	Rattus norvegicus	233-243
23775122-3	2013	Site-specific mutational analysis showed that PMA increased serine phosphorylation at three sites on IRS2 (positions 303, 343, and 675), which affected insulin-induced tyrosine phosphorylation of IRS2 at positions 653, 671, and 911 (p-Tyr-IRS2) and p-Akt/eNOS.	Tetradecanoylphorbol Acetate	46-49	AKT serine/threonine kinase 1	Rattus norvegicus	251-254
23764888-5	2013	Arazyme inhibited the secretion of IL-6 and IL-8 due to phorbol 12-myristate 13-acetate and calcium ionophores in human mast cells.	Tetradecanoylphorbol Acetate	56-87	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
23715767-7	2013	Suppression of Egr-1 expression by siRNA abrogated the ability of TPA to induce Egr-1 and JNK-1 activities, moderately increasing the p21 activity and abrogating the anti-apoptotic effect of Egr-1 observed in the prostate cancer cell lines.	Tetradecanoylphorbol Acetate	66-69	mitogen-activated protein kinase 8	Homo sapiens	90-95
23704110-8	2013	CONCLUSIONS: In our sample of tissue-type plasminogen activator-treated (tPA) patients, ~1 in 5 patients developed SIRS.	Tetradecanoylphorbol Acetate	73-76	plasminogen activator, tissue type	Homo sapiens	30-64
23715767-6	2013	The expression of Egr-1, p21 and JNK was strongly increased after treatment of the cells with TPA, tumor necrosis factor-alpha (TNF-alpha) or arsenite.	Tetradecanoylphorbol Acetate	94-97	cyclin dependent kinase inhibitor 1A	Homo sapiens	25-28
23715767-6	2013	The expression of Egr-1, p21 and JNK was strongly increased after treatment of the cells with TPA, tumor necrosis factor-alpha (TNF-alpha) or arsenite.	Tetradecanoylphorbol Acetate	94-97	mitogen-activated protein kinase 8	Homo sapiens	33-36
23786520-3	2013	Herein, it was investigated whether 1 and three other flavonoids [chrysin (2), apigenin (3), and tricetin (4)] blocked 12-O-tetradecanoylphorbol 13-acetate (TPA)-triggered induction of CD families, which were induced through the activation of protein kinase C (PKC), mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK), and NADPH oxidase (NOX)-derived reactive oxygen species (ROS).	Tetradecanoylphorbol Acetate	119-155	mitogen-activated protein kinase kinase 7	Homo sapiens	267-299
23775084-5	2013	We show that both chemical suppression and siRNA silencing of PP2Ac in T-cells resulted in sustained phosphorylation of MEK and ERK following stimulation with phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	159-190	mitogen-activated protein kinase kinase 7	Homo sapiens	120-123
23775084-5	2013	We show that both chemical suppression and siRNA silencing of PP2Ac in T-cells resulted in sustained phosphorylation of MEK and ERK following stimulation with phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	159-190	mitogen-activated protein kinase 1	Homo sapiens	128-131
23786520-3	2013	Herein, it was investigated whether 1 and three other flavonoids [chrysin (2), apigenin (3), and tricetin (4)] blocked 12-O-tetradecanoylphorbol 13-acetate (TPA)-triggered induction of CD families, which were induced through the activation of protein kinase C (PKC), mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK), and NADPH oxidase (NOX)-derived reactive oxygen species (ROS).	Tetradecanoylphorbol Acetate	119-155	mitogen-activated protein kinase kinase 7	Homo sapiens	301-304
23786520-3	2013	Herein, it was investigated whether 1 and three other flavonoids [chrysin (2), apigenin (3), and tricetin (4)] blocked 12-O-tetradecanoylphorbol 13-acetate (TPA)-triggered induction of CD families, which were induced through the activation of protein kinase C (PKC), mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK), and NADPH oxidase (NOX)-derived reactive oxygen species (ROS).	Tetradecanoylphorbol Acetate	119-155	mitogen-activated protein kinase 1	Homo sapiens	345-348
25654138-3	2013	Also, inhibitors of these protein activity suppressed PMA-induced morphological change of THP1 cells.	Tetradecanoylphorbol Acetate	54-57	GLI family zinc finger 2	Homo sapiens	90-94
23621670-5	2013	METHOD OF STUDY: THP-1 cells were cultured in two conditions and treated with phorbol 12-myristate 13-acetate (PMA) or MCSF.	Tetradecanoylphorbol Acetate	78-109	GLI family zinc finger 2	Homo sapiens	17-22
23621670-5	2013	METHOD OF STUDY: THP-1 cells were cultured in two conditions and treated with phorbol 12-myristate 13-acetate (PMA) or MCSF.	Tetradecanoylphorbol Acetate	111-114	GLI family zinc finger 2	Homo sapiens	17-22
23846803-9	2013	These effects of IL-1beta were shown to be regulated by the PKC agonist, phorbol 12-myristate 13-acetate, and Rho kinase agonist and antagonist, angiotensin II, and Y-27632, respectively.	Tetradecanoylphorbol Acetate	73-104	interleukin-1 beta	Oryctolagus cuniculus	17-25
24455888-4	2013	The transfer of the cells from medium with HSA-Cl and myeloperoxidase to fresh medium abolished an increase in PMA-induced luminol-dependent chemiluminescence, but not the ability of neutrophils to respond to re-addition of HSA-Cl.	Tetradecanoylphorbol Acetate	111-114	myeloperoxidase	Homo sapiens	54-69
24455888-7	2013	A significant positive correlation was found between myeloperoxidase activity in blood plasma of children with severe burns and the enhancing effects of albumin fraction of the same plasma on luminol-dependent chemiluminescence of PMA-stimulated donor neutrophils.	Tetradecanoylphorbol Acetate	231-234	myeloperoxidase	Homo sapiens	53-68
23536578-8	2013	In Nanog-expressing human embryonal carcinoma cell lines, NT2/D1 and NCCIT, Nanog expression was suppressed by exposure to PKC activator Phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	137-168	protein kinase C alpha	Homo sapiens	123-126
23536578-8	2013	In Nanog-expressing human embryonal carcinoma cell lines, NT2/D1 and NCCIT, Nanog expression was suppressed by exposure to PKC activator Phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	170-173	protein kinase C alpha	Homo sapiens	123-126
23376232-6	2013	We found that the presence of sulfite can cause MPO-catalyzed oxidation of MPO to a protein radical in phorbol 12-myristate 13-acetate-activated human neutrophils.	Tetradecanoylphorbol Acetate	103-134	myeloperoxidase	Homo sapiens	48-51
23376232-6	2013	We found that the presence of sulfite can cause MPO-catalyzed oxidation of MPO to a protein radical in phorbol 12-myristate 13-acetate-activated human neutrophils.	Tetradecanoylphorbol Acetate	103-134	myeloperoxidase	Homo sapiens	75-78
23519462-7	2013	GLP-1 release was increased to 2.6-fold the control value by forskolin + isobutylmethylxanthine (10 mumol/l each), 2.8-fold by phorbol myristate acetate (1 mumol/l) and 1.4-fold by linoleic acid (100 mumol/l).	Tetradecanoylphorbol Acetate	127-152	glucagon	Homo sapiens	0-5
23640176-9	2013	In addition, CORT application further resulted in a significant enhancement of ASIC1a current in the presence of phorbol 12-myristate 13-acetate (0.5 muM) or bryostatin1 (1 muM), which are both protein kinase C (PKC) agonists.	Tetradecanoylphorbol Acetate	113-144	latexin	Homo sapiens	150-153
23726966-7	2013	In addition, persicarin and I3G reduced PMA-stimulated phosphorylation of p38MAPK, extracellular regulated kinases (ERK) 1/2, and c-Jun N-terminal kinase (JNK).	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 3	Homo sapiens	83-124
23726966-7	2013	In addition, persicarin and I3G reduced PMA-stimulated phosphorylation of p38MAPK, extracellular regulated kinases (ERK) 1/2, and c-Jun N-terminal kinase (JNK).	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 8	Homo sapiens	130-153
23726966-7	2013	In addition, persicarin and I3G reduced PMA-stimulated phosphorylation of p38MAPK, extracellular regulated kinases (ERK) 1/2, and c-Jun N-terminal kinase (JNK).	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 8	Homo sapiens	155-158
23806369-8	2013	With knockdown of LSD1, H3K4 methylation at IL-6 promoter was found increased after TPA treatment at different times points (all P&lt;0.05, except 24 hours).	Tetradecanoylphorbol Acetate	84-87	interleukin 6	Homo sapiens	44-48
23429041-6	2013	DHA also remarkably reduced PMA-induced p65, C/EBPbeta, c-jun and CREB nuclear translocation.	Tetradecanoylphorbol Acetate	28-31	cAMP responsive element binding protein 1	Mus musculus	66-70
23429041-7	2013	Furthermore, DHA evidently inhibited PMA-induced phosphorylation of AKT and the MAP Kinases, such as ERK, JNK and p38.	Tetradecanoylphorbol Acetate	37-40	thymoma viral proto-oncogene 1	Mus musculus	68-71
23569086-5	2013	Moreover, stimulation of protein kinase C with phorbol-12-myristate-13-acetate mimicked the effect of AngII and increased Cl channel activity.	Tetradecanoylphorbol Acetate	47-78	angiotensinogen	Homo sapiens	102-107
23399806-9	2013	Further, TPA induced altered expression of NF-kappaB (p65) and COX-2 was also attenuated by GOH.	Tetradecanoylphorbol Acetate	9-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	43-52
23702712-9	2013	RESULTS: Enzyme-linked immunosorbent assay and AP assay showed interleukin-1beta-induced TNF-alpha shedding in HCT116 and HT29 cells and TPA-induced TNF-alpha release in U937 cells.	Tetradecanoylphorbol Acetate	137-140	tumor necrosis factor	Homo sapiens	149-158
23702712-10	2013	KB-R7785 and ADAM17 depletion significantly blocked TNF-alpha shedding by TPA.	Tetradecanoylphorbol Acetate	74-77	tumor necrosis factor	Homo sapiens	52-61
23702712-11	2013	ANX A2 depletion significantly inhibited TNF-alpha shedding by interleukin-1beta and TPA.	Tetradecanoylphorbol Acetate	85-88	tumor necrosis factor	Homo sapiens	41-50
23702712-14	2013	CONCLUSIONS: ANX A2 was closely associated with ADAM17 and played an important role in TNF-alpha shedding by TPA.	Tetradecanoylphorbol Acetate	109-112	tumor necrosis factor	Homo sapiens	87-96
22351517-6	2013	TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Homo sapiens	62-78
22351517-6	2013	TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	93-102
22351517-6	2013	TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin.	Tetradecanoylphorbol Acetate	0-3	interleukin 6	Homo sapiens	115-128
22351517-6	2013	TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin.	Tetradecanoylphorbol Acetate	0-3	interleukin 6	Homo sapiens	130-134
22351517-6	2013	TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	141-162
22351517-6	2013	TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Homo sapiens	80-85
22351517-6	2013	TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	88-91
23769052-7	2013	Interferon (IFN)-gamma production was induced only by PMA/ionomycin (P &lt; .01) but not by PHA (P = NS).	Tetradecanoylphorbol Acetate	54-57	interferon gamma	Homo sapiens	0-22
22351517-6	2013	TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	164-167
22351517-7	2013	Fluocinolone acetonide (FA) (a full GR agonist) was able to completely reverse the above effects of TPA.	Tetradecanoylphorbol Acetate	100-103	nuclear receptor subfamily 3 group C member 1	Homo sapiens	36-38
22351517-9	2013	However, CpdA treatment resulted in a decrease in the number of p50 positive cells induced by TPA, suggesting its role in inhibition of NF-kappaB.	Tetradecanoylphorbol Acetate	94-97	nuclear factor kappa B subunit 1	Homo sapiens	64-67
23589028-0	2013	Interferon-gamma enhances phorbol myristate acetate-induced cell attachment and tumor necrosis factor production via the NF-kappaB pathway in THP-1 human monocytic cells.	Tetradecanoylphorbol Acetate	26-51	interferon gamma	Homo sapiens	0-16
23589028-0	2013	Interferon-gamma enhances phorbol myristate acetate-induced cell attachment and tumor necrosis factor production via the NF-kappaB pathway in THP-1 human monocytic cells.	Tetradecanoylphorbol Acetate	26-51	tumor necrosis factor	Homo sapiens	80-101
23589028-0	2013	Interferon-gamma enhances phorbol myristate acetate-induced cell attachment and tumor necrosis factor production via the NF-kappaB pathway in THP-1 human monocytic cells.	Tetradecanoylphorbol Acetate	26-51	GLI family zinc finger 2	Homo sapiens	142-147
23589028-2	2013	THP-1 non-adherent human monocytic cells differentiate into plastic-adherent macrophages via alphaVbeta3 integrin, by ERK activation in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	152-177	GLI family zinc finger 2	Homo sapiens	0-5
23589028-2	2013	THP-1 non-adherent human monocytic cells differentiate into plastic-adherent macrophages via alphaVbeta3 integrin, by ERK activation in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	179-182	GLI family zinc finger 2	Homo sapiens	0-5
23769052-14	2013	In contrast, CD4(+) CD25(+) FoxP3(+) CD127(-) Treg are inducible by PMA/ionomycin and PHA stimulation.	Tetradecanoylphorbol Acetate	68-71	CD4 molecule	Homo sapiens	13-16
23021516-8	2013	However, AA increased PGD2 and TNF-alpha secretion by ionomycin/phorbol 12-myristate 13-acetate-stimulated HMC-1, whereas EPA and DHA more prominently inhibited IL-4 and IL-13 secretion.	Tetradecanoylphorbol Acetate	64-95	prostaglandin D2 synthase	Homo sapiens	22-26
23021516-8	2013	However, AA increased PGD2 and TNF-alpha secretion by ionomycin/phorbol 12-myristate 13-acetate-stimulated HMC-1, whereas EPA and DHA more prominently inhibited IL-4 and IL-13 secretion.	Tetradecanoylphorbol Acetate	64-95	tumor necrosis factor	Homo sapiens	31-40
23288142-8	2013	EMSA showed that DHA, LA, PD98059, and wortmannin decreased TPA-induced NF-kappaB and AP-1 DNA-binding activity.	Tetradecanoylphorbol Acetate	60-63	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-90
23708096-2	2013	Topical application of LicE (0.5-2 mg) effectively inhibited TPA-induced (1) ear edema formation; (2) phosphorylation of stress-activated protein kinase/c-Jun-N-terminal kinase (SAPK/JNK), c-Jun, and extracellular signal regulated kinase 1/2; and (3) expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins in mouse skin.	Tetradecanoylphorbol Acetate	61-64	nitric oxide synthase 2, inducible	Mus musculus	265-296
23708096-2	2013	Topical application of LicE (0.5-2 mg) effectively inhibited TPA-induced (1) ear edema formation; (2) phosphorylation of stress-activated protein kinase/c-Jun-N-terminal kinase (SAPK/JNK), c-Jun, and extracellular signal regulated kinase 1/2; and (3) expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins in mouse skin.	Tetradecanoylphorbol Acetate	61-64	nitric oxide synthase 2, inducible	Mus musculus	298-302
23658802-4	2013	Neuroserpin, an endogenous inhibitor of tPA, is up-regulated following cerebral ischemia.	Tetradecanoylphorbol Acetate	40-43	serine (or cysteine) peptidase inhibitor, clade I, member 1	Mus musculus	0-11
23635876-7	2013	Glomerular mRNA expression of KLF2 and KLF4 correlated with that of tPA and inversely with that of PAI-1 in rTx-TMA.	Tetradecanoylphorbol Acetate	68-71	Kruppel like factor 2	Homo sapiens	30-34
23675462-5	2013	Here, we demonstrate that both MSK1 and MSK2, regulate the phorbol ester 12-O-tetradecanoylphorbol-13-acetate induced expression of the breast cancer marker gene, trefoil factor 1 (TFF1), by phosphorylating H3S10 at its 5" regulatory regions.	Tetradecanoylphorbol Acetate	73-109	trefoil factor 1	Homo sapiens	163-179
23675462-5	2013	Here, we demonstrate that both MSK1 and MSK2, regulate the phorbol ester 12-O-tetradecanoylphorbol-13-acetate induced expression of the breast cancer marker gene, trefoil factor 1 (TFF1), by phosphorylating H3S10 at its 5" regulatory regions.	Tetradecanoylphorbol Acetate	73-109	trefoil factor 1	Homo sapiens	181-185
23525112-3	2013	Inhibition of NF-kappaB reversed both H2O2- and phorbol 12-myristate 13-acetate (PMA)-induced decrease in TRPC6 protein expression.	Tetradecanoylphorbol Acetate	48-79	nuclear factor kappa B subunit 1	Homo sapiens	14-23
23525112-3	2013	Inhibition of NF-kappaB reversed both H2O2- and phorbol 12-myristate 13-acetate (PMA)-induced decrease in TRPC6 protein expression.	Tetradecanoylphorbol Acetate	81-84	nuclear factor kappa B subunit 1	Homo sapiens	14-23
23288142-5	2013	Treatment with PD98059 (10 muM), wortmannin (10 muM), and GF109203X (0.5 muM) decreased TPA-induced MMP-9 protein expression and enzyme activity.	Tetradecanoylphorbol Acetate	88-91	latexin	Homo sapiens	27-30
23288142-5	2013	Treatment with PD98059 (10 muM), wortmannin (10 muM), and GF109203X (0.5 muM) decreased TPA-induced MMP-9 protein expression and enzyme activity.	Tetradecanoylphorbol Acetate	88-91	latexin	Homo sapiens	48-51
23288142-5	2013	Treatment with PD98059 (10 muM), wortmannin (10 muM), and GF109203X (0.5 muM) decreased TPA-induced MMP-9 protein expression and enzyme activity.	Tetradecanoylphorbol Acetate	88-91	latexin	Homo sapiens	48-51
23114726-0	2013	Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 breast adenocarcinoma cells invasion/migration by alpha-tomatine through activating PKCalpha/ERK/NF-kappaB-dependent MMP-2/MMP-9 expressions.	Tetradecanoylphorbol Acetate	15-51	protein kinase C alpha	Homo sapiens	150-158
23288142-6	2013	TPA-induced activation of ERK1, Akt, and PKCdelta was attenuated by DHA, whereas LA attenuated only ERK1 activation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	26-30
23288142-6	2013	TPA-induced activation of ERK1, Akt, and PKCdelta was attenuated by DHA, whereas LA attenuated only ERK1 activation.	Tetradecanoylphorbol Acetate	0-3	AKT serine/threonine kinase 1	Homo sapiens	32-35
23114726-7	2013	The treatment of specific inhibitor for ERK (U0126) to MCF-7 cells could inhibit TPA-induced MMP-2/MMP-9 and phospho-ERK along with an inhibition on cell invasion and migration.	Tetradecanoylphorbol Acetate	81-84	mitogen-activated protein kinase 1	Homo sapiens	40-43
23114726-7	2013	The treatment of specific inhibitor for ERK (U0126) to MCF-7 cells could inhibit TPA-induced MMP-2/MMP-9 and phospho-ERK along with an inhibition on cell invasion and migration.	Tetradecanoylphorbol Acetate	81-84	mitogen-activated protein kinase 1	Homo sapiens	117-120
23114726-0	2013	Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 breast adenocarcinoma cells invasion/migration by alpha-tomatine through activating PKCalpha/ERK/NF-kappaB-dependent MMP-2/MMP-9 expressions.	Tetradecanoylphorbol Acetate	15-51	mitogen-activated protein kinase 1	Homo sapiens	159-162
23114726-0	2013	Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 breast adenocarcinoma cells invasion/migration by alpha-tomatine through activating PKCalpha/ERK/NF-kappaB-dependent MMP-2/MMP-9 expressions.	Tetradecanoylphorbol Acetate	15-51	nuclear factor kappa B subunit 1	Homo sapiens	163-172
23114726-4	2013	Data also showed alpha-tomatine could inhibit the activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and protein kinase C-alpha (PKCalpha) involved in the downregulation of the enzyme activities and messenger RNA levels of matrix metalloproteinase-2/9 (MMP-2/MMP-9) induced by TPA.	Tetradecanoylphorbol Acetate	295-298	protein kinase C alpha	Homo sapiens	147-155
23114726-5	2013	Next, alpha-tomatine also strongly inhibited TPA-induced the activation of nuclear factor kappa B (NF-kappaB) and phospho-inhibitor of kappa Balpha (phospho-IkappaBalpha).	Tetradecanoylphorbol Acetate	45-48	nuclear factor kappa B subunit 1	Homo sapiens	75-97
23114726-5	2013	Next, alpha-tomatine also strongly inhibited TPA-induced the activation of nuclear factor kappa B (NF-kappaB) and phospho-inhibitor of kappa Balpha (phospho-IkappaBalpha).	Tetradecanoylphorbol Acetate	45-48	nuclear factor kappa B subunit 1	Homo sapiens	99-108
23114726-5	2013	Next, alpha-tomatine also strongly inhibited TPA-induced the activation of nuclear factor kappa B (NF-kappaB) and phospho-inhibitor of kappa Balpha (phospho-IkappaBalpha).	Tetradecanoylphorbol Acetate	45-48	NFKB inhibitor alpha	Homo sapiens	157-169
23114726-6	2013	In addition, TPA-induced translocation of PKC-alpha from cytosol to membranes, and suppression of TPA elicited the expression of PKC-alpha by adding the PKC-alpha inhibitors, GF-109203X and Go-6983.	Tetradecanoylphorbol Acetate	13-16	protein kinase C alpha	Homo sapiens	42-51
23114726-6	2013	In addition, TPA-induced translocation of PKC-alpha from cytosol to membranes, and suppression of TPA elicited the expression of PKC-alpha by adding the PKC-alpha inhibitors, GF-109203X and Go-6983.	Tetradecanoylphorbol Acetate	13-16	protein kinase C alpha	Homo sapiens	129-138
23114726-6	2013	In addition, TPA-induced translocation of PKC-alpha from cytosol to membranes, and suppression of TPA elicited the expression of PKC-alpha by adding the PKC-alpha inhibitors, GF-109203X and Go-6983.	Tetradecanoylphorbol Acetate	13-16	protein kinase C alpha	Homo sapiens	129-138
23114726-6	2013	In addition, TPA-induced translocation of PKC-alpha from cytosol to membranes, and suppression of TPA elicited the expression of PKC-alpha by adding the PKC-alpha inhibitors, GF-109203X and Go-6983.	Tetradecanoylphorbol Acetate	98-101	protein kinase C alpha	Homo sapiens	129-138
23114726-6	2013	In addition, TPA-induced translocation of PKC-alpha from cytosol to membranes, and suppression of TPA elicited the expression of PKC-alpha by adding the PKC-alpha inhibitors, GF-109203X and Go-6983.	Tetradecanoylphorbol Acetate	98-101	protein kinase C alpha	Homo sapiens	129-138
23671446-9	2013	At concentrations of 5, 10 and 20 microM, it was significantly inhibited the PMA-induced expressions of MMP-1 (2.27 +-0.10, 1.98 +-0.11 and 1.56 +-0.15; p &lt; 0.001) and MMP-13 (0.89 +-0.04, 0.81 +-0.07, and 0.74 +-0.09; p &lt; 0.001), respectively.	Tetradecanoylphorbol Acetate	77-80	matrix metallopeptidase 13	Homo sapiens	171-177
23643258-4	2013	Moreover, IFN-gamma, IL-4, IL-9 and IL-17 secreted by gammadeltaT cells were detected by means of intracellular cytokine staining after stimulation with PMA plus ionomycin.	Tetradecanoylphorbol Acetate	153-156	interferon gamma	Mus musculus	10-19
23589925-13	2013	The calcium flux effect of PMA is related to the difference between PMA and histamine on the effects of AA release and GPI formation via activation on PLA2.	Tetradecanoylphorbol Acetate	27-30	phospholipase A2 group IB	Homo sapiens	151-155
23671446-11	2013	In addition, this sedative drug inhibited PMA-induced levels of phos-ERK (1.243 +-0.12, 1.108 +-0.16 and 0.903 +-0.19, respectively) and phos-p38 (1.146 +-0.10, 1.063 +-0.13 and 0.946 +-0.18, at concentrations of (5, 10 and 20 microM), respectively.	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 1	Homo sapiens	69-72
23671446-11	2013	In addition, this sedative drug inhibited PMA-induced levels of phos-ERK (1.243 +-0.12, 1.108 +-0.16 and 0.903 +-0.19, respectively) and phos-p38 (1.146 +-0.10, 1.063 +-0.13 and 0.946 +-0.18, at concentrations of (5, 10 and 20 microM), respectively.	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 14	Homo sapiens	142-145
23671446-12	2013	CONCLUSIONS: These results are important for understanding the mechanism of midazolam in inhibiting PMA-induced MMP expression through the signaling pathways of either NF-kappaB or ERK/p38 MAPKs down-regulation.	Tetradecanoylphorbol Acetate	100-103	mitogen-activated protein kinase 1	Homo sapiens	181-184
23726630-5	2013	The immunosuppressive therapy was monitored pre- and posttransplantation at 4, 12, and 24 months using triple fluorescence flow cytometry for intracellular interleukin (Il)-2 Il-4 and interferon (IFN)-gamma production in phorbol myristate acetate- and lipopolysaccharide- stimulated lymphocyte cultures.	Tetradecanoylphorbol Acetate	221-246	interferon gamma	Homo sapiens	184-206
23416458-5	2013	Higher levels of IL-17 and IFN-gamma were produced by stimulation with PMA/Ionomycin compared to anti-CD3/anti-CD28.	Tetradecanoylphorbol Acetate	71-74	interferon gamma	Homo sapiens	27-36
23416458-8	2013	Furthermore the dose response curve for PMA/Ionomycin differed for IL-10 compared to IL-17 and IFN-gamma as it was biphasic with no IL-10 production at higher PMA/Ionomycin concentrations.	Tetradecanoylphorbol Acetate	40-43	interferon gamma	Homo sapiens	95-104
23671446-12	2013	CONCLUSIONS: These results are important for understanding the mechanism of midazolam in inhibiting PMA-induced MMP expression through the signaling pathways of either NF-kappaB or ERK/p38 MAPKs down-regulation.	Tetradecanoylphorbol Acetate	100-103	mitogen-activated protein kinase 14	Homo sapiens	185-188
23347208-7	2013	THP-1 cells exhibited M2-polarized phenotype markers with high proportion of CD68(+) , CD206(+) and CD204(+) markers after phorbol 12-myristate 13-acetate (PMA) treatment, After co-culturing with TAM cells in a transwell chamber system, EOC cells (SKOV3) increased their IL-8 expression at the level of mRNA and protein.	Tetradecanoylphorbol Acetate	156-159	C-X-C motif chemokine ligand 8	Homo sapiens	271-275
23501100-2	2013	In this study, we revealed that the expression of PU.1 was increased and accompanied by downregulation of MT-1A expression during TPA-induced THP-1 monocyte differentiation.	Tetradecanoylphorbol Acetate	130-133	metallothionein 1A	Homo sapiens	106-111
23501100-2	2013	In this study, we revealed that the expression of PU.1 was increased and accompanied by downregulation of MT-1A expression during TPA-induced THP-1 monocyte differentiation.	Tetradecanoylphorbol Acetate	130-133	GLI family zinc finger 2	Homo sapiens	142-147
23615261-6	2013	TPA substantially increased NF-kappaB and AP-1 DNA binding activity.	Tetradecanoylphorbol Acetate	0-3	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-46
23377348-5	2013	Pretreatment of NHBEs with MAL3-101 attenuated in a concentration-dependent manner PMA-stimulated mucin secretion and interactions among HSP70, MARCKS, and CSP.	Tetradecanoylphorbol Acetate	83-86	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	156-159
23488631-3	2013	SI, AD, and DM reduced a mean phorbol-12-myristate-13-acetate/ionomycin (PMA/I)-stimulated release of the pro-inflammatory interleukins IL-6 and IL-8 by more than 50% (p &lt; 0.05).	Tetradecanoylphorbol Acetate	30-61	interleukin 6	Homo sapiens	136-140
23488631-3	2013	SI, AD, and DM reduced a mean phorbol-12-myristate-13-acetate/ionomycin (PMA/I)-stimulated release of the pro-inflammatory interleukins IL-6 and IL-8 by more than 50% (p &lt; 0.05).	Tetradecanoylphorbol Acetate	30-61	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
23315006-9	2013	Also, viability decreased by over 90 % after treatment with 1.2 muM farnesol for 24 h. The TPA detected a significant increase in active caspase-3 after treatment with 2 and 4 muM farnesol for 2 h, which could not be detected using standard methods such as western blot and immunofluorescence.	Tetradecanoylphorbol Acetate	91-94	latexin	Homo sapiens	64-67
23315006-9	2013	Also, viability decreased by over 90 % after treatment with 1.2 muM farnesol for 24 h. The TPA detected a significant increase in active caspase-3 after treatment with 2 and 4 muM farnesol for 2 h, which could not be detected using standard methods such as western blot and immunofluorescence.	Tetradecanoylphorbol Acetate	91-94	caspase 3	Homo sapiens	137-146
23315006-9	2013	Also, viability decreased by over 90 % after treatment with 1.2 muM farnesol for 24 h. The TPA detected a significant increase in active caspase-3 after treatment with 2 and 4 muM farnesol for 2 h, which could not be detected using standard methods such as western blot and immunofluorescence.	Tetradecanoylphorbol Acetate	91-94	latexin	Homo sapiens	176-179
23315006-11	2013	Caspase-3 expression fell significantly in cells that were treated with 0.25 muM farnesol for 2 h. Further, by TPA, active caspase-3 peaked after 2 h and declined with longer incubation times.	Tetradecanoylphorbol Acetate	111-114	caspase 3	Homo sapiens	0-9
23315006-11	2013	Caspase-3 expression fell significantly in cells that were treated with 0.25 muM farnesol for 2 h. Further, by TPA, active caspase-3 peaked after 2 h and declined with longer incubation times.	Tetradecanoylphorbol Acetate	111-114	latexin	Homo sapiens	77-80
23315006-11	2013	Caspase-3 expression fell significantly in cells that were treated with 0.25 muM farnesol for 2 h. Further, by TPA, active caspase-3 peaked after 2 h and declined with longer incubation times.	Tetradecanoylphorbol Acetate	111-114	caspase 3	Homo sapiens	123-132
23315006-12	2013	This study demonstrates that cleaved caspase-3 is detected and quantified reliably in meningiomas by TPA.	Tetradecanoylphorbol Acetate	101-104	caspase 3	Homo sapiens	37-46
23291558-7	2013	cAMP-response element (CRE)-dependent induction of Per1 promoter activity in response to FSK in combination with phorbol 12-tetradecanoate 13-acetate was suppressed in cells that expressed high levels of AhR (c7) compared with cells lacking functional AhR activity (c12).	Tetradecanoylphorbol Acetate	113-149	aryl-hydrocarbon receptor	Mus musculus	204-207
23353996-6	2013	In addition, TPA-induced phosphorylation of MEK and ERK was also inhibited             by silibinin.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase kinase 7	Homo sapiens	44-47
23353996-6	2013	In addition, TPA-induced phosphorylation of MEK and ERK was also inhibited             by silibinin.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 1	Homo sapiens	52-55
23353996-7	2013	Taken together, we suggest that silibinin suppresses TPA-induced             cell migration and MMP-9 expression through the MEK/ERK-dependent pathway in thyroid             and breast cancer cells.	Tetradecanoylphorbol Acetate	53-56	mitogen-activated protein kinase kinase 7	Homo sapiens	125-128
23353996-7	2013	Taken together, we suggest that silibinin suppresses TPA-induced             cell migration and MMP-9 expression through the MEK/ERK-dependent pathway in thyroid             and breast cancer cells.	Tetradecanoylphorbol Acetate	53-56	mitogen-activated protein kinase 1	Homo sapiens	129-132
23490067-0	2013	Arachidonic acid enhances TPA-induced differentiation in human leukemia HL-60 cells via reactive oxygen species-dependent ERK activation.	Tetradecanoylphorbol Acetate	26-29	mitogen-activated protein kinase 1	Homo sapiens	122-125
23490067-5	2013	Furthermore, activation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) by TPA+AA was identified in HL-60 cells, and the ERK inhibitor, PD98059, but not the JNK inhibitor, SP600125, inhibited TPA+AA-induced NBT-positive cells.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase 1	Homo sapiens	27-57
23490067-5	2013	Furthermore, activation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) by TPA+AA was identified in HL-60 cells, and the ERK inhibitor, PD98059, but not the JNK inhibitor, SP600125, inhibited TPA+AA-induced NBT-positive cells.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase 1	Homo sapiens	59-62
23490067-5	2013	Furthermore, activation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) by TPA+AA was identified in HL-60 cells, and the ERK inhibitor, PD98059, but not the JNK inhibitor, SP600125, inhibited TPA+AA-induced NBT-positive cells.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase 8	Homo sapiens	68-91
23490067-5	2013	Furthermore, activation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) by TPA+AA was identified in HL-60 cells, and the ERK inhibitor, PD98059, but not the JNK inhibitor, SP600125, inhibited TPA+AA-induced NBT-positive cells.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase 8	Homo sapiens	93-96
23490067-5	2013	Furthermore, activation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) by TPA+AA was identified in HL-60 cells, and the ERK inhibitor, PD98059, but not the JNK inhibitor, SP600125, inhibited TPA+AA-induced NBT-positive cells.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase 1	Homo sapiens	147-150
23353996-3	2013	Our results revealed that the levels             of MMP-9 mRNA and protein expression were significantly increased by TPA but not             MMP-2 in TPC-1 and MCF7 cells.	Tetradecanoylphorbol Acetate	118-121	two pore segment channel 1	Homo sapiens	151-156
23353996-4	2013	To verify the regulatory mechanism of TPA-induced             MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126,             and TPA-induced MMP-9 expression was significantly decreased.	Tetradecanoylphorbol Acetate	38-41	two pore segment channel 1	Homo sapiens	91-96
23353996-4	2013	To verify the regulatory mechanism of TPA-induced             MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126,             and TPA-induced MMP-9 expression was significantly decreased.	Tetradecanoylphorbol Acetate	162-165	two pore segment channel 1	Homo sapiens	91-96
23490067-5	2013	Furthermore, activation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) by TPA+AA was identified in HL-60 cells, and the ERK inhibitor, PD98059, but not the JNK inhibitor, SP600125, inhibited TPA+AA-induced NBT-positive cells.	Tetradecanoylphorbol Acetate	218-221	mitogen-activated protein kinase 1	Homo sapiens	27-57
23490067-5	2013	Furthermore, activation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) by TPA+AA was identified in HL-60 cells, and the ERK inhibitor, PD98059, but not the JNK inhibitor, SP600125, inhibited TPA+AA-induced NBT-positive cells.	Tetradecanoylphorbol Acetate	218-221	mitogen-activated protein kinase 1	Homo sapiens	59-62
23490067-5	2013	Furthermore, activation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) by TPA+AA was identified in HL-60 cells, and the ERK inhibitor, PD98059, but not the JNK inhibitor, SP600125, inhibited TPA+AA-induced NBT-positive cells.	Tetradecanoylphorbol Acetate	218-221	mitogen-activated protein kinase 8	Homo sapiens	68-91
23490067-5	2013	Furthermore, activation of extracellular-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) by TPA+AA was identified in HL-60 cells, and the ERK inhibitor, PD98059, but not the JNK inhibitor, SP600125, inhibited TPA+AA-induced NBT-positive cells.	Tetradecanoylphorbol Acetate	218-221	mitogen-activated protein kinase 8	Homo sapiens	93-96
23490067-6	2013	Suppression of TPA+AA-induced ERK protein phosphorylation by PD98059 and NAC was detected, and AA enhanced ERK protein phosphorylation by TPA was in HL-60 cells.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 1	Homo sapiens	30-33
23490067-6	2013	Suppression of TPA+AA-induced ERK protein phosphorylation by PD98059 and NAC was detected, and AA enhanced ERK protein phosphorylation by TPA was in HL-60 cells.	Tetradecanoylphorbol Acetate	138-141	mitogen-activated protein kinase 1	Homo sapiens	107-110
23490067-9	2013	Evidence of AA potentiation of differentiation by TPA in human leukemia cells HL-60 via activation of ROS-dependent ERK protein phosphorylation was first demonstrated herein.	Tetradecanoylphorbol Acetate	50-53	mitogen-activated protein kinase 1	Homo sapiens	116-119
23335792-4	2013	phorbol 12-myristate 13-acetate-activated THP-1 macrophages were transfected with negative control or MyD88 small interfering (si)RNA.	Tetradecanoylphorbol Acetate	0-31	GLI family zinc finger 2	Homo sapiens	42-47
22961925-0	2013	Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 1	Homo sapiens	46-49
23313748-6	2013	Activation of PKC by 12-O-tetradecanoylphorbol-13-acetate dramatically decreased MCM7 DNA replication licensing and induced cell growth arrest.	Tetradecanoylphorbol Acetate	21-57	proline rich transmembrane protein 2	Homo sapiens	14-17
23408313-0	2013	Propyl gallate inhibits TPA-induced inflammation via the nuclear factor-kappaB pathway in human THP-1 monocytes.	Tetradecanoylphorbol Acetate	24-27	GLI family zinc finger 2	Homo sapiens	96-101
23408313-2	2013	The present study examined the anti-inflammatory effect of PG on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in human THP-1 monocytes.	Tetradecanoylphorbol Acetate	65-101	GLI family zinc finger 2	Homo sapiens	138-143
23408313-2	2013	The present study examined the anti-inflammatory effect of PG on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in human THP-1 monocytes.	Tetradecanoylphorbol Acetate	103-106	GLI family zinc finger 2	Homo sapiens	138-143
23408313-3	2013	Pretreatment with PG markedly inhibited the TPA-induced expression levels of cyclooxygenase-2 and prostaglandin E2.	Tetradecanoylphorbol Acetate	44-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	77-93
23339930-6	2013	The changes 8 h after TPA treatment probably reflected transcriptional regulation, and the genes were divided into three groups, up-regulated (IL-6, MCP-1, HO-1 and SOCS3), unregulated (IL-1beta, TNF-alpha and IL-10) and down-regulated (RANTES) genes.	Tetradecanoylphorbol Acetate	22-25	interleukin 6	Mus musculus	143-147
23339930-6	2013	The changes 8 h after TPA treatment probably reflected transcriptional regulation, and the genes were divided into three groups, up-regulated (IL-6, MCP-1, HO-1 and SOCS3), unregulated (IL-1beta, TNF-alpha and IL-10) and down-regulated (RANTES) genes.	Tetradecanoylphorbol Acetate	22-25	mast cell protease 1	Mus musculus	149-154
23339930-6	2013	The changes 8 h after TPA treatment probably reflected transcriptional regulation, and the genes were divided into three groups, up-regulated (IL-6, MCP-1, HO-1 and SOCS3), unregulated (IL-1beta, TNF-alpha and IL-10) and down-regulated (RANTES) genes.	Tetradecanoylphorbol Acetate	22-25	heme oxygenase 1	Mus musculus	156-160
23339930-6	2013	The changes 8 h after TPA treatment probably reflected transcriptional regulation, and the genes were divided into three groups, up-regulated (IL-6, MCP-1, HO-1 and SOCS3), unregulated (IL-1beta, TNF-alpha and IL-10) and down-regulated (RANTES) genes.	Tetradecanoylphorbol Acetate	22-25	interleukin 1 beta	Mus musculus	186-194
23339930-6	2013	The changes 8 h after TPA treatment probably reflected transcriptional regulation, and the genes were divided into three groups, up-regulated (IL-6, MCP-1, HO-1 and SOCS3), unregulated (IL-1beta, TNF-alpha and IL-10) and down-regulated (RANTES) genes.	Tetradecanoylphorbol Acetate	22-25	tumor necrosis factor	Mus musculus	196-205
23339930-6	2013	The changes 8 h after TPA treatment probably reflected transcriptional regulation, and the genes were divided into three groups, up-regulated (IL-6, MCP-1, HO-1 and SOCS3), unregulated (IL-1beta, TNF-alpha and IL-10) and down-regulated (RANTES) genes.	Tetradecanoylphorbol Acetate	22-25	interleukin 10	Mus musculus	210-215
23339930-6	2013	The changes 8 h after TPA treatment probably reflected transcriptional regulation, and the genes were divided into three groups, up-regulated (IL-6, MCP-1, HO-1 and SOCS3), unregulated (IL-1beta, TNF-alpha and IL-10) and down-regulated (RANTES) genes.	Tetradecanoylphorbol Acetate	22-25	chemokine (C-C motif) ligand 5	Mus musculus	237-243
23339930-7	2013	TPA-induced gene expression of cytokines, except for RANTES, peaked at 8 h and significantly declined in the late phase in control mice, while the expression of IL-1beta and TNF-alpha did not decline in the late phase in the diabetic mice.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Mus musculus	161-169
23339930-7	2013	TPA-induced gene expression of cytokines, except for RANTES, peaked at 8 h and significantly declined in the late phase in control mice, while the expression of IL-1beta and TNF-alpha did not decline in the late phase in the diabetic mice.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Mus musculus	174-183
23274527-2	2013	The involvement of phospholipase A(2) (PLA(2)) in phorbol myristate acetate (PMA)-induced activation of the two pools of NADPH-oxidase was investigated using a variety of PLA(2) inhibitors and the oxidase activity was measured by luminol/isoluminol-amplified chemiluminescence (CL).	Tetradecanoylphorbol Acetate	50-75	phospholipase A2 group IB	Homo sapiens	19-37
23274527-2	2013	The involvement of phospholipase A(2) (PLA(2)) in phorbol myristate acetate (PMA)-induced activation of the two pools of NADPH-oxidase was investigated using a variety of PLA(2) inhibitors and the oxidase activity was measured by luminol/isoluminol-amplified chemiluminescence (CL).	Tetradecanoylphorbol Acetate	50-75	phospholipase A2 group IB	Homo sapiens	39-45
23274527-2	2013	The involvement of phospholipase A(2) (PLA(2)) in phorbol myristate acetate (PMA)-induced activation of the two pools of NADPH-oxidase was investigated using a variety of PLA(2) inhibitors and the oxidase activity was measured by luminol/isoluminol-amplified chemiluminescence (CL).	Tetradecanoylphorbol Acetate	77-80	phospholipase A2 group IB	Homo sapiens	19-37
23274527-2	2013	The involvement of phospholipase A(2) (PLA(2)) in phorbol myristate acetate (PMA)-induced activation of the two pools of NADPH-oxidase was investigated using a variety of PLA(2) inhibitors and the oxidase activity was measured by luminol/isoluminol-amplified chemiluminescence (CL).	Tetradecanoylphorbol Acetate	77-80	phospholipase A2 group IB	Homo sapiens	39-45
23408313-4	2013	The application of PG significantly inhibited the nuclear translocation of p65, a subunit of nuclear factor-kappaB (NF-kappaB) and phosphorylation of p65 (Ser536) in TPA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	166-169	GLI family zinc finger 2	Homo sapiens	178-183
23408313-6	2013	These results indicate that PG inhibits the inflammatory response by blocking the NF-kappaB signaling pathway in TPA-induced THP-1 monocytes.	Tetradecanoylphorbol Acetate	113-116	GLI family zinc finger 2	Homo sapiens	125-130
22961925-2	2013	In the present study role of p38 MAPK and extracellular signal regulated kinase (ERK) against phorbol 12-myristate 13-acetate (PMA) induced reactive oxygen species (ROS) generation and NETs formation has been investigated.	Tetradecanoylphorbol Acetate	127-130	mitogen-activated protein kinase 1	Homo sapiens	33-37
22961925-2	2013	In the present study role of p38 MAPK and extracellular signal regulated kinase (ERK) against phorbol 12-myristate 13-acetate (PMA) induced reactive oxygen species (ROS) generation and NETs formation has been investigated.	Tetradecanoylphorbol Acetate	127-130	mitogen-activated protein kinase 1	Homo sapiens	42-79
22961925-2	2013	In the present study role of p38 MAPK and extracellular signal regulated kinase (ERK) against phorbol 12-myristate 13-acetate (PMA) induced reactive oxygen species (ROS) generation and NETs formation has been investigated.	Tetradecanoylphorbol Acetate	127-130	mitogen-activated protein kinase 1	Homo sapiens	81-84
22961925-0	2013	Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 1	Homo sapiens	54-57
22961925-2	2013	In the present study role of p38 MAPK and extracellular signal regulated kinase (ERK) against phorbol 12-myristate 13-acetate (PMA) induced reactive oxygen species (ROS) generation and NETs formation has been investigated.	Tetradecanoylphorbol Acetate	94-125	mitogen-activated protein kinase 1	Homo sapiens	29-32
22961925-2	2013	In the present study role of p38 MAPK and extracellular signal regulated kinase (ERK) against phorbol 12-myristate 13-acetate (PMA) induced reactive oxygen species (ROS) generation and NETs formation has been investigated.	Tetradecanoylphorbol Acetate	94-125	mitogen-activated protein kinase 1	Homo sapiens	33-37
22961925-2	2013	In the present study role of p38 MAPK and extracellular signal regulated kinase (ERK) against phorbol 12-myristate 13-acetate (PMA) induced reactive oxygen species (ROS) generation and NETs formation has been investigated.	Tetradecanoylphorbol Acetate	94-125	mitogen-activated protein kinase 1	Homo sapiens	42-79
22961925-2	2013	In the present study role of p38 MAPK and extracellular signal regulated kinase (ERK) against phorbol 12-myristate 13-acetate (PMA) induced reactive oxygen species (ROS) generation and NETs formation has been investigated.	Tetradecanoylphorbol Acetate	94-125	mitogen-activated protein kinase 1	Homo sapiens	81-84
22961925-2	2013	In the present study role of p38 MAPK and extracellular signal regulated kinase (ERK) against phorbol 12-myristate 13-acetate (PMA) induced reactive oxygen species (ROS) generation and NETs formation has been investigated.	Tetradecanoylphorbol Acetate	127-130	mitogen-activated protein kinase 1	Homo sapiens	29-32
22610793-4	2013	The human monocyte THP-1 cells were differentiated to macrophage cells in the presence of phorbol 12-myristate13-acetate (PMA).	Tetradecanoylphorbol Acetate	90-120	GLI family zinc finger 2	Homo sapiens	19-24
23292685-0	2013	Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition             of NF-kappaB-dependent MMP-9 expression.	Tetradecanoylphorbol Acetate	15-18	nuclear factor kappa B subunit 1	Homo sapiens	91-100
23292685-7	2013	Sulfuretin inhibited TPA-induced             transcriptional activation of nuclear factor-kappaB (NF-kappaB).	Tetradecanoylphorbol Acetate	21-24	nuclear factor kappa B subunit 1	Homo sapiens	75-96
23292685-7	2013	Sulfuretin inhibited TPA-induced             transcriptional activation of nuclear factor-kappaB (NF-kappaB).	Tetradecanoylphorbol Acetate	21-24	nuclear factor kappa B subunit 1	Homo sapiens	98-107
22610793-4	2013	The human monocyte THP-1 cells were differentiated to macrophage cells in the presence of phorbol 12-myristate13-acetate (PMA).	Tetradecanoylphorbol Acetate	122-125	GLI family zinc finger 2	Homo sapiens	19-24
23288845-5	2013	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated apoE secretion, and both PMA-induced and apoAI-induced apoE secretion were inhibited by PKC inhibitors.	Tetradecanoylphorbol Acetate	18-49	proline rich transmembrane protein 2	Homo sapiens	4-7
22469974-5	2013	In cells, RhoGDI2 becomes rapidly phosphorylated at Ser31 in response to phorbol 12-myristate 13-acetate stimulation.	Tetradecanoylphorbol Acetate	73-104	Rho GDP dissociation inhibitor beta	Homo sapiens	10-17
23430963-4	2013	We observed that, in human neutrophils, calcium ionophore induced histone deimination, whereas phorbol myristate acetate (PMA), an activator of protein kinase C (PKC), suppressed ionophore-induced deimination.	Tetradecanoylphorbol Acetate	95-120	protein kinase C alpha	Homo sapiens	162-165
23430963-4	2013	We observed that, in human neutrophils, calcium ionophore induced histone deimination, whereas phorbol myristate acetate (PMA), an activator of protein kinase C (PKC), suppressed ionophore-induced deimination.	Tetradecanoylphorbol Acetate	122-125	protein kinase C alpha	Homo sapiens	162-165
23430963-6	2013	In addition, a peptide inhibitor of PKCalpha superinduced ionophore activation of PAD4, thus identifying PKCalpha as the PMA-induced inhibitor of PAD4.	Tetradecanoylphorbol Acetate	121-124	protein kinase C alpha	Homo sapiens	36-44
23430963-6	2013	In addition, a peptide inhibitor of PKCalpha superinduced ionophore activation of PAD4, thus identifying PKCalpha as the PMA-induced inhibitor of PAD4.	Tetradecanoylphorbol Acetate	121-124	protein kinase C alpha	Homo sapiens	105-113
23288845-5	2013	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated apoE secretion, and both PMA-induced and apoAI-induced apoE secretion were inhibited by PKC inhibitors.	Tetradecanoylphorbol Acetate	18-49	apolipoprotein E	Homo sapiens	67-71
23288845-5	2013	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated apoE secretion, and both PMA-induced and apoAI-induced apoE secretion were inhibited by PKC inhibitors.	Tetradecanoylphorbol Acetate	18-49	apolipoprotein E	Homo sapiens	122-126
23288845-5	2013	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated apoE secretion, and both PMA-induced and apoAI-induced apoE secretion were inhibited by PKC inhibitors.	Tetradecanoylphorbol Acetate	18-49	proline rich transmembrane protein 2	Homo sapiens	155-158
23288845-5	2013	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated apoE secretion, and both PMA-induced and apoAI-induced apoE secretion were inhibited by PKC inhibitors.	Tetradecanoylphorbol Acetate	51-54	proline rich transmembrane protein 2	Homo sapiens	4-7
23288845-5	2013	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated apoE secretion, and both PMA-induced and apoAI-induced apoE secretion were inhibited by PKC inhibitors.	Tetradecanoylphorbol Acetate	51-54	apolipoprotein E	Homo sapiens	67-71
23288845-5	2013	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated apoE secretion, and both PMA-induced and apoAI-induced apoE secretion were inhibited by PKC inhibitors.	Tetradecanoylphorbol Acetate	51-54	apolipoprotein E	Homo sapiens	122-126
23288845-5	2013	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated apoE secretion, and both PMA-induced and apoAI-induced apoE secretion were inhibited by PKC inhibitors.	Tetradecanoylphorbol Acetate	51-54	proline rich transmembrane protein 2	Homo sapiens	155-158
23017670-3	2013	Early apoptosis and necrosis rates as well as co-expression of immunostimulatory and immunosuppressive proteins in/on CD4(+)CD25(+)Foxp3(+), CD4(+)IFNgamma(+)Foxp3(+) and CD4(+)CD25(+)IFNgamma(+) PBL were analyzed using cells from healthy controls and four-color flow cytometry, PMA/Ionomycin-stimulated PBL, and MLC.	Tetradecanoylphorbol Acetate	279-282	CD4 molecule	Homo sapiens	118-121
23268563-6	2013	Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion.	Tetradecanoylphorbol Acetate	6-37	TIMP metallopeptidase inhibitor 1	Homo sapiens	185-224
23268563-6	2013	Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion.	Tetradecanoylphorbol Acetate	6-37	TIMP metallopeptidase inhibitor 1	Homo sapiens	226-232
23268563-6	2013	Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion.	Tetradecanoylphorbol Acetate	39-42	TIMP metallopeptidase inhibitor 1	Homo sapiens	185-224
23268563-6	2013	Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion.	Tetradecanoylphorbol Acetate	39-42	TIMP metallopeptidase inhibitor 1	Homo sapiens	226-232
23017670-6	2013	CD4(+)CD25(+)IFNgamma(+) and CD4(+)CD25(+)CD178(+) PBL separated from primary cell cultures and added to autologous PMA/Ionomycin stimulated secondary cell cultures induced apoptosis immediately.	Tetradecanoylphorbol Acetate	116-119	CD4 molecule	Homo sapiens	0-3
24049660-11	2013	The significantly increased postchallenge concentrations of IL-2, IL-8, IL-12p70, IL-13, IL-18, IFN- gamma , TNF- alpha , and TGF- beta were released by peripheral blood cells after stimulation with PMA, as compared with both their prechallenge concentrations and with the PBS control values.	Tetradecanoylphorbol Acetate	199-202	interleukin 2	Homo sapiens	60-64
24049660-11	2013	The significantly increased postchallenge concentrations of IL-2, IL-8, IL-12p70, IL-13, IL-18, IFN- gamma , TNF- alpha , and TGF- beta were released by peripheral blood cells after stimulation with PMA, as compared with both their prechallenge concentrations and with the PBS control values.	Tetradecanoylphorbol Acetate	199-202	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
24049660-11	2013	The significantly increased postchallenge concentrations of IL-2, IL-8, IL-12p70, IL-13, IL-18, IFN- gamma , TNF- alpha , and TGF- beta were released by peripheral blood cells after stimulation with PMA, as compared with both their prechallenge concentrations and with the PBS control values.	Tetradecanoylphorbol Acetate	199-202	interleukin 13	Homo sapiens	82-87
24049660-11	2013	The significantly increased postchallenge concentrations of IL-2, IL-8, IL-12p70, IL-13, IL-18, IFN- gamma , TNF- alpha , and TGF- beta were released by peripheral blood cells after stimulation with PMA, as compared with both their prechallenge concentrations and with the PBS control values.	Tetradecanoylphorbol Acetate	199-202	interferon gamma	Homo sapiens	96-106
24049660-11	2013	The significantly increased postchallenge concentrations of IL-2, IL-8, IL-12p70, IL-13, IL-18, IFN- gamma , TNF- alpha , and TGF- beta were released by peripheral blood cells after stimulation with PMA, as compared with both their prechallenge concentrations and with the PBS control values.	Tetradecanoylphorbol Acetate	199-202	tumor necrosis factor	Homo sapiens	109-119
24049660-11	2013	The significantly increased postchallenge concentrations of IL-2, IL-8, IL-12p70, IL-13, IL-18, IFN- gamma , TNF- alpha , and TGF- beta were released by peripheral blood cells after stimulation with PMA, as compared with both their prechallenge concentrations and with the PBS control values.	Tetradecanoylphorbol Acetate	199-202	transforming growth factor beta 1	Homo sapiens	126-135
23374270-7	2013	This deletion abrogated protein expression and activation of the canonical nuclear factor kappaB (NF-kappaB) pathway in lymphocytes after antigen receptor or phorbol 12-myristate 13-acetate stimulation, whereas CD40 signaling in B cells was preserved.	Tetradecanoylphorbol Acetate	158-189	nuclear factor kappa B subunit 1	Homo sapiens	90-96
23333628-3	2013	Recently, we demonstrated that histamine or phorbol-12-myristate-13-acetate (PMA) stimulation induced the up-regulation of H1R gene expression through the protein kinase Cdelta (PKCdelta)/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells expressing H1R endogenously.	Tetradecanoylphorbol Acetate	44-75	histamine receptor H 1	Rattus norvegicus	299-302
23333628-3	2013	Recently, we demonstrated that histamine or phorbol-12-myristate-13-acetate (PMA) stimulation induced the up-regulation of H1R gene expression through the protein kinase Cdelta (PKCdelta)/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells expressing H1R endogenously.	Tetradecanoylphorbol Acetate	77-80	histamine receptor H 1	Rattus norvegicus	299-302
23242121-3	2013	Cis-guggulsterone inhibited TPA-induced MMP expression             by blocking IkappaB kinase (IKK)/NF-kappaB signaling, whereas trans-guggulsterone blocked             mitogen-activated protein kinase (MAPK)/AP-1 signaling.	Tetradecanoylphorbol Acetate	28-31	nuclear factor kappa B subunit 1	Homo sapiens	100-109
23242121-3	2013	Cis-guggulsterone inhibited TPA-induced MMP expression             by blocking IkappaB kinase (IKK)/NF-kappaB signaling, whereas trans-guggulsterone blocked             mitogen-activated protein kinase (MAPK)/AP-1 signaling.	Tetradecanoylphorbol Acetate	28-31	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	209-213
23374270-7	2013	This deletion abrogated protein expression and activation of the canonical nuclear factor kappaB (NF-kappaB) pathway in lymphocytes after antigen receptor or phorbol 12-myristate 13-acetate stimulation, whereas CD40 signaling in B cells was preserved.	Tetradecanoylphorbol Acetate	158-189	nuclear factor kappa B subunit 1	Homo sapiens	98-107
23346086-6	2012	Pharmacological inhibition of MPO and the use of MPO-deficient neutrophils indicate active MPO is required with phorbol myristate acetate as a stimulus but not necessarily with bacteria.	Tetradecanoylphorbol Acetate	112-137	myeloperoxidase	Homo sapiens	30-33
23440225-3	2013	Activation of PKC by phorbol 12-myristate 13-acetate (PMA) causes activation of extracellular signal-regulated kinase (ERK) and promotes the formation of new spines in cultured hippocampal neurons.	Tetradecanoylphorbol Acetate	21-52	mitogen-activated protein kinase 1	Homo sapiens	80-117
23440225-3	2013	Activation of PKC by phorbol 12-myristate 13-acetate (PMA) causes activation of extracellular signal-regulated kinase (ERK) and promotes the formation of new spines in cultured hippocampal neurons.	Tetradecanoylphorbol Acetate	21-52	mitogen-activated protein kinase 1	Homo sapiens	119-122
23440225-3	2013	Activation of PKC by phorbol 12-myristate 13-acetate (PMA) causes activation of extracellular signal-regulated kinase (ERK) and promotes the formation of new spines in cultured hippocampal neurons.	Tetradecanoylphorbol Acetate	54-57	mitogen-activated protein kinase 1	Homo sapiens	80-117
23440225-3	2013	Activation of PKC by phorbol 12-myristate 13-acetate (PMA) causes activation of extracellular signal-regulated kinase (ERK) and promotes the formation of new spines in cultured hippocampal neurons.	Tetradecanoylphorbol Acetate	54-57	mitogen-activated protein kinase 1	Homo sapiens	119-122
23232714-6	2013	In addition, miR-127-3p also decreased neoplastic cell transformation in TPA-induced JB6 mouse epidermal and MC-3 cells.	Tetradecanoylphorbol Acetate	73-76	microRNA 1273a	Homo sapiens	13-23
23346086-6	2012	Pharmacological inhibition of MPO and the use of MPO-deficient neutrophils indicate active MPO is required with phorbol myristate acetate as a stimulus but not necessarily with bacteria.	Tetradecanoylphorbol Acetate	112-137	myeloperoxidase	Homo sapiens	49-52
23346086-6	2012	Pharmacological inhibition of MPO and the use of MPO-deficient neutrophils indicate active MPO is required with phorbol myristate acetate as a stimulus but not necessarily with bacteria.	Tetradecanoylphorbol Acetate	112-137	myeloperoxidase	Homo sapiens	49-52
24073399-1	2013	This study evaluated the chemical properties (polyphenol and genistein contents) of soybean extracts obtained by biotransformation and dried by spray dryer at different conditions and their in vivo ability to inhibit 12-O-tetradecanoylphorbol-13-acetate- (TPA-) induced biochemical alterations in the skin of hairless mice.	Tetradecanoylphorbol Acetate	217-253	promotion susceptibility QTL 1	Mus musculus	256-259
23123205-8	2013	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) increased MeCP2 expression in naive P19 cells, which was also blocked by NFkappaB inhibitors.	Tetradecanoylphorbol Acetate	31-62	methyl-CpG binding protein 2	Homo sapiens	79-84
23123205-8	2013	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) increased MeCP2 expression in naive P19 cells, which was also blocked by NFkappaB inhibitors.	Tetradecanoylphorbol Acetate	31-62	nuclear factor kappa B subunit 1	Homo sapiens	142-150
23123205-8	2013	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) increased MeCP2 expression in naive P19 cells, which was also blocked by NFkappaB inhibitors.	Tetradecanoylphorbol Acetate	64-67	methyl-CpG binding protein 2	Homo sapiens	79-84
23123205-8	2013	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) increased MeCP2 expression in naive P19 cells, which was also blocked by NFkappaB inhibitors.	Tetradecanoylphorbol Acetate	64-67	nuclear factor kappa B subunit 1	Homo sapiens	142-150
23099255-5	2013	At the intracellular level, euphol reduced TPA-induced extracellular signal-regulated protein kinase (ERK) activation and cyclooxygenase-2 (COX-2) upregulation.	Tetradecanoylphorbol Acetate	43-46	mitogen-activated protein kinase 1	Mus musculus	55-100
23099255-5	2013	At the intracellular level, euphol reduced TPA-induced extracellular signal-regulated protein kinase (ERK) activation and cyclooxygenase-2 (COX-2) upregulation.	Tetradecanoylphorbol Acetate	43-46	mitogen-activated protein kinase 1	Mus musculus	102-105
23099255-6	2013	These effects were associated with euphol"s ability to prevent TPA-induced protein kinase C (PKC) activation, namely PKCalpha and PKCdelta isozymes.	Tetradecanoylphorbol Acetate	63-66	protein kinase C, alpha	Mus musculus	117-125
24804016-6	2013	Gene expression results in HUVEC showed that cinnamon extract treatment inhibited TPA induction of protein kinase C, PKCalpha and PKCeta messenger RNA (mRNA) expression in a dose-dependent manner along with suppression of vascular endothelial growth factor receptor 1 (VEGFR1/Flt1) and vascular endothelial growth factor receptor 2 (VEGFR2/KDR/Flk1) mRNA expression.	Tetradecanoylphorbol Acetate	82-85	fms related receptor tyrosine kinase 1	Homo sapiens	269-275
22955945-5	2013	RGD-anxA5 enhances engulfment of apoptotic cells by phorbol-12-myristate-13-acetate-stimulated THP-1 (human acute monocytic leukemia cell line) cells in vitro and resident peritoneal mouse macrophages in vivo.	Tetradecanoylphorbol Acetate	52-83	GLI family zinc finger 2	Homo sapiens	95-100
24335179-0	2013	Berberine suppresses TPA-induced fibronectin expression through the inhibition of VEGF secretion in breast cancer cells.	Tetradecanoylphorbol Acetate	21-24	fibronectin 1	Homo sapiens	33-44
24335179-0	2013	Berberine suppresses TPA-induced fibronectin expression through the inhibition of VEGF secretion in breast cancer cells.	Tetradecanoylphorbol Acetate	21-24	vascular endothelial growth factor A	Homo sapiens	82-86
24335179-3	2013	Here, we investigated the effect of BBR on TPA-induced VEGF and fibronectin (FN) as well as VEGF-induced FN in breast cancer cells.	Tetradecanoylphorbol Acetate	43-46	vascular endothelial growth factor A	Homo sapiens	55-59
24335179-7	2013	RESULTS: Our results showed that TPA, a tumor promoter, significantly increased the level of VEGF and FN expression in both MCF7 and T47D breast cancer cells.	Tetradecanoylphorbol Acetate	33-36	vascular endothelial growth factor A	Homo sapiens	93-97
24335179-7	2013	RESULTS: Our results showed that TPA, a tumor promoter, significantly increased the level of VEGF and FN expression in both MCF7 and T47D breast cancer cells.	Tetradecanoylphorbol Acetate	33-36	fibronectin 1	Homo sapiens	102-104
24335179-8	2013	On the other hand, TPA-induced VEGF and FN expression was suppressed by LY294002, a PI-3K inhibitor.	Tetradecanoylphorbol Acetate	19-22	vascular endothelial growth factor A	Homo sapiens	31-35
24335179-8	2013	On the other hand, TPA-induced VEGF and FN expression was suppressed by LY294002, a PI-3K inhibitor.	Tetradecanoylphorbol Acetate	19-22	fibronectin 1	Homo sapiens	40-42
24335179-10	2013	We also found that TPA-induced VEGF and FN expression was decreased by BBR treatment.	Tetradecanoylphorbol Acetate	19-22	vascular endothelial growth factor A	Homo sapiens	31-35
24335179-10	2013	We also found that TPA-induced VEGF and FN expression was decreased by BBR treatment.	Tetradecanoylphorbol Acetate	19-22	fibronectin 1	Homo sapiens	40-42
24335179-12	2013	CONCLUSION: Taken together, we suggest that BBR may suppress TPA-induced VEGF and FN as well as VEGF-induced FN through the inhibition of the PI-3K/AKT pathway in breast cancer cells.	Tetradecanoylphorbol Acetate	61-64	vascular endothelial growth factor A	Homo sapiens	73-77
24335179-12	2013	CONCLUSION: Taken together, we suggest that BBR may suppress TPA-induced VEGF and FN as well as VEGF-induced FN through the inhibition of the PI-3K/AKT pathway in breast cancer cells.	Tetradecanoylphorbol Acetate	61-64	fibronectin 1	Homo sapiens	82-84
23175175-0	2013	Induction of differentiation-specific miRNAs in TPA-induced myeloid             leukemia cells through MEK/ERK activation.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 1	Homo sapiens	107-110
23175175-4	2013	The upregulation of these miRNAs was further verified by             quantitative RT-PCR, and, markedly, a subset of the miRNAs was found to be induced             via the MEK/ERK signaling pathway using TPA and specific pharmacological inhibitors.	Tetradecanoylphorbol Acetate	204-207	mitogen-activated protein kinase kinase 7	Homo sapiens	172-175
23175175-0	2013	Induction of differentiation-specific miRNAs in TPA-induced myeloid             leukemia cells through MEK/ERK activation.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase kinase 7	Homo sapiens	103-106
23175175-4	2013	The upregulation of these miRNAs was further verified by             quantitative RT-PCR, and, markedly, a subset of the miRNAs was found to be induced             via the MEK/ERK signaling pathway using TPA and specific pharmacological inhibitors.	Tetradecanoylphorbol Acetate	204-207	mitogen-activated protein kinase 1	Homo sapiens	176-179
23175175-6	2013	Therefore, we identified the unique             miRNAs that respond to TPA treatment in leukemia cells and demonstrated the essential             role of the MEK/ERK signaling pathway in the induction of these miRNA transcripts.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase kinase 7	Homo sapiens	158-161
23175175-6	2013	Therefore, we identified the unique             miRNAs that respond to TPA treatment in leukemia cells and demonstrated the essential             role of the MEK/ERK signaling pathway in the induction of these miRNA transcripts.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase 1	Homo sapiens	162-165
23147225-5	2013	However, the transgene-derived TACE could be converted to an active form by furin in vitro and by phorbol myristate acetate (PMA) in vivo.	Tetradecanoylphorbol Acetate	98-123	a disintegrin and metallopeptidase domain 17	Mus musculus	31-35
23151889-5	2013	Surfactin attenuated TPA-induced nuclear             translocation and activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1             (AP-1).	Tetradecanoylphorbol Acetate	21-24	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-142
23151889-5	2013	Surfactin attenuated TPA-induced nuclear             translocation and activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1             (AP-1).	Tetradecanoylphorbol Acetate	21-24	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	156-160
23151889-6	2013	Furthermore, surfactin strongly repressed the TPA-induced phosphorylation             of Akt and extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	46-49	AKT serine/threonine kinase 1	Homo sapiens	89-92
23151889-6	2013	Furthermore, surfactin strongly repressed the TPA-induced phosphorylation             of Akt and extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 1	Homo sapiens	97-134
23151889-6	2013	Furthermore, surfactin strongly repressed the TPA-induced phosphorylation             of Akt and extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 1	Homo sapiens	136-139
23147224-12	2013	Ethanol and phorbol myristate acetate synergistically increased CX3CL1 release.	Tetradecanoylphorbol Acetate	12-37	C-X3-C motif chemokine ligand 1	Rattus norvegicus	64-70
23147225-5	2013	However, the transgene-derived TACE could be converted to an active form by furin in vitro and by phorbol myristate acetate (PMA) in vivo.	Tetradecanoylphorbol Acetate	125-128	a disintegrin and metallopeptidase domain 17	Mus musculus	31-35
24008321-0	2013	Effect of phorbol 12-myristate 13-acetate on function and gene expression of P-glycoprotein in adriamycin-resistant K562/ADM cells.	Tetradecanoylphorbol Acetate	10-41	ATP binding cassette subfamily B member 1	Homo sapiens	77-91
22981962-0	2012	Soy isoflavones (daidzein &amp; genistein) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cutaneous inflammation via modulation of COX-2 and NF-kappaB in Swiss albino mice.	Tetradecanoylphorbol Acetate	89-92	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	153-162
23326123-20	2012	Pretreatment with various concentrations of PMA (10 nmol/L-10 mumol/L) apparently inhibited the effect of CCK-8S and the effect of 100 nmol/L PMA was most obvious.	Tetradecanoylphorbol Acetate	44-47	skull morphology 14	Mus musculus	57-61
23308155-8	2013	VEGF, IL-8 and effusion size correlated positively with PAI-1/tPA ratio in both UPPE and CPPE.	Tetradecanoylphorbol Acetate	62-65	vascular endothelial growth factor A	Homo sapiens	0-4
23658523-3	2013	TCR or phorbal ester (PMA) signaling strongly induced phosphorylation of the CDK9 kinase at Ser175.	Tetradecanoylphorbol Acetate	22-25	cyclin dependent kinase 9	Homo sapiens	77-81
23286450-4	2012	Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes.	Tetradecanoylphorbol Acetate	21-52	GLI family zinc finger 2	Homo sapiens	62-67
23286450-4	2012	Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes.	Tetradecanoylphorbol Acetate	21-52	GLI family zinc finger 2	Homo sapiens	79-84
23286450-4	2012	Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes.	Tetradecanoylphorbol Acetate	21-52	nuclear factor kappa B subunit 1	Homo sapiens	203-211
23286450-4	2012	Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes.	Tetradecanoylphorbol Acetate	21-52	GLI family zinc finger 2	Homo sapiens	79-84
23286450-4	2012	Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes.	Tetradecanoylphorbol Acetate	54-57	GLI family zinc finger 2	Homo sapiens	62-67
23286450-4	2012	Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes.	Tetradecanoylphorbol Acetate	54-57	GLI family zinc finger 2	Homo sapiens	79-84
23286450-4	2012	Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes.	Tetradecanoylphorbol Acetate	54-57	nuclear factor kappa B subunit 1	Homo sapiens	203-211
23286450-4	2012	Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes.	Tetradecanoylphorbol Acetate	54-57	GLI family zinc finger 2	Homo sapiens	79-84
23286450-6	2012	In conclusion, microwave radiations were found to inhibit the activity functions of THP-1 monocytes stimulated with PMA and LPS.	Tetradecanoylphorbol Acetate	116-119	GLI family zinc finger 2	Homo sapiens	84-89
23253724-4	2012	METHODS: We established three cell models; HSFb activated by TNF-alpha, THP-1 cells activated by phorbol 12-myristate 13-acetate (PMA) and an HSFb-THP-1 co-culture system.	Tetradecanoylphorbol Acetate	97-128	GLI family zinc finger 2	Homo sapiens	72-77
23105117-5	2012	VRK2 increases NFAT1-dependent transcription by phosphorylation, and this effect is only detected following cell phorbol 12-myristate 13-acetate and ionomycin stimulation and calcineurin activation.	Tetradecanoylphorbol Acetate	113-144	VRK serine/threonine kinase 2	Homo sapiens	0-4
23105117-8	2012	Therefore, VRK2 down-regulation reduces cell invasion by tumor cells, such as MDA-MB-231 and MDA-MB-435, upon stimulation with phorbol 12-myristate 13-acetate plus ionomycin.	Tetradecanoylphorbol Acetate	127-158	VRK serine/threonine kinase 2	Homo sapiens	11-15
23169656-1	2012	We have determined the effects of myosin binding protein-C (MyBP-C) and its domains on the microsecond rotational dynamics of actin, detected by time-resolved phosphorescence anisotropy (TPA).	Tetradecanoylphorbol Acetate	187-190	myosin binding protein C3	Homo sapiens	34-58
23169656-1	2012	We have determined the effects of myosin binding protein-C (MyBP-C) and its domains on the microsecond rotational dynamics of actin, detected by time-resolved phosphorescence anisotropy (TPA).	Tetradecanoylphorbol Acetate	187-190	myosin binding protein C3	Homo sapiens	60-66
23169656-5	2012	The interaction of all three MyBP-C isoforms with actin increased the final anisotropy of the TPA decay, indicating restriction of the amplitude of actin torsional flexibility by 15-20  at saturation of the TPA effect.	Tetradecanoylphorbol Acetate	94-97	myosin binding protein C3	Homo sapiens	29-35
23169656-5	2012	The interaction of all three MyBP-C isoforms with actin increased the final anisotropy of the TPA decay, indicating restriction of the amplitude of actin torsional flexibility by 15-20  at saturation of the TPA effect.	Tetradecanoylphorbol Acetate	207-210	myosin binding protein C3	Homo sapiens	29-35
23216989-7	2012	In contrast, PMA-induced THP-1 differentiation toward monocytic cells expressed CD11b+, and CD14+, but not CD123, and revealed exclusively IL-12 expression while stimulated by dengue-2.	Tetradecanoylphorbol Acetate	13-16	GLI family zinc finger 2	Homo sapiens	25-30
23169635-5	2012	In contrast, PC1(hi) cells produced more IL-10 than PC1(lo) cells when stimulated with LPS and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	95-126	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	13-16
23169635-5	2012	In contrast, PC1(hi) cells produced more IL-10 than PC1(lo) cells when stimulated with LPS and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	128-131	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	13-16
23100250-5	2012	A diphosphorylated form of p57/coronin-1 was detected after the cells were treated with phorbol 12-myristate 13-acetate plus calyculin A.	Tetradecanoylphorbol Acetate	88-119	coronin 1A	Homo sapiens	27-30
23100250-5	2012	A diphosphorylated form of p57/coronin-1 was detected after the cells were treated with phorbol 12-myristate 13-acetate plus calyculin A.	Tetradecanoylphorbol Acetate	88-119	coronin 1A	Homo sapiens	31-40
23070544-8	2012	Protein kinase C (PKC) inhibitor GF109203X abrogated the effects of TNF-alpha, whereas the pan-PKC activator phorbol 12-myristate 13-acetate mimicked the TNF-alpha effects.	Tetradecanoylphorbol Acetate	109-140	tumor necrosis factor	Homo sapiens	154-163
22989505-8	2012	Further mechanistic studies demonstrated that ezetimibe suppressed the PMA-induced phosphorylation of ERK/MAPK and inhibited the NF-kappaB activity, which are upstream signalling molecules in the differentiation process.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase 1	Homo sapiens	102-105
22740037-0	2012	Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-kappaB activation in TPA-induced breast cancer cells.	Tetradecanoylphorbol Acetate	119-122	nuclear factor kappa B subunit 1	Homo sapiens	95-104
22740037-9	2012	Thus, transfection of breast cancer cells with PI3K/Akt and ERK1/2 siRNAs significantly decreased TPA-induced MMP-9 and COX-2 expression.	Tetradecanoylphorbol Acetate	98-101	AKT serine/threonine kinase 1	Homo sapiens	52-55
22740037-9	2012	Thus, transfection of breast cancer cells with PI3K/Akt and ERK1/2 siRNAs significantly decreased TPA-induced MMP-9 and COX-2 expression.	Tetradecanoylphorbol Acetate	98-101	mitogen-activated protein kinase 3	Homo sapiens	60-66
22740037-10	2012	These results suggest that ar-turmerone suppressed the TPA-induced up-regulation of MMP-9 and COX-2 expression by blocking NF-kappaB, PI3K/Akt, and ERK1/2 signaling in human breast cancer cells.	Tetradecanoylphorbol Acetate	55-58	nuclear factor kappa B subunit 1	Homo sapiens	123-132
22740037-10	2012	These results suggest that ar-turmerone suppressed the TPA-induced up-regulation of MMP-9 and COX-2 expression by blocking NF-kappaB, PI3K/Akt, and ERK1/2 signaling in human breast cancer cells.	Tetradecanoylphorbol Acetate	55-58	AKT serine/threonine kinase 1	Homo sapiens	139-142
22740037-10	2012	These results suggest that ar-turmerone suppressed the TPA-induced up-regulation of MMP-9 and COX-2 expression by blocking NF-kappaB, PI3K/Akt, and ERK1/2 signaling in human breast cancer cells.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 3	Homo sapiens	148-154
23123091-0	2012	Involvement of PTEN in TPA-mediated p53-activation in mouse skin epidermal JB6 cells.	Tetradecanoylphorbol Acetate	23-26	phosphatase and tensin homolog	Mus musculus	15-19
23123091-3	2012	We used murine skin epidermal JB6 promotion-sensitive (P+) and promotion resistant (P-) cells to observe differential expression of PTEN during TPA-induced p53 activation.	Tetradecanoylphorbol Acetate	144-147	phosphatase and tensin homolog	Mus musculus	132-136
23123091-5	2012	Nuclear expression of PTEN increased and complex formation between PTEN and p53 occurred in P+ cells treated with TPA.	Tetradecanoylphorbol Acetate	114-117	phosphatase and tensin homolog	Mus musculus	22-26
23123091-5	2012	Nuclear expression of PTEN increased and complex formation between PTEN and p53 occurred in P+ cells treated with TPA.	Tetradecanoylphorbol Acetate	114-117	phosphatase and tensin homolog	Mus musculus	67-71
23123091-6	2012	Knocking down PTEN expression via siRNA inhibited TPA-induced Bax expression.	Tetradecanoylphorbol Acetate	50-53	phosphatase and tensin homolog	Mus musculus	14-18
23123091-9	2012	Our findings suggest PTEN mediates TPA-induced p53 activation.	Tetradecanoylphorbol Acetate	35-38	phosphatase and tensin homolog	Mus musculus	21-25
22771957-3	2012	Here, we report that, although Ei24 homozygous knockout mice are embryonic lethal, Ei24 heterozygous null mice are attenuated to DMBA/TPA-induced carcinogenesis with regard to the number and size of tumors but not the incidence.	Tetradecanoylphorbol Acetate	134-137	etoposide induced 2.4 mRNA	Mus musculus	83-87
23098038-2	2012	Using a combination of virtual screening and experimental testing, novel small molecule inhibitors of tPA-mediated extracellular signal-regulated kinase (Erk)1/2 activation were identified that provide higher levels of neuroprotection from Abeta-induced apoptosis than Memantine, the most recently FDA-approved drug for AD treatment.	Tetradecanoylphorbol Acetate	102-105	mitogen-activated protein kinase 3	Homo sapiens	115-161
23098038-2	2012	Using a combination of virtual screening and experimental testing, novel small molecule inhibitors of tPA-mediated extracellular signal-regulated kinase (Erk)1/2 activation were identified that provide higher levels of neuroprotection from Abeta-induced apoptosis than Memantine, the most recently FDA-approved drug for AD treatment.	Tetradecanoylphorbol Acetate	102-105	amyloid beta precursor protein	Homo sapiens	240-245
22986104-3	2012	TPA induced the expression of critical events of tumorigenesis like ornithine decarboxylase, cyclooxygenase-2, interleukin-6 and pSTAT3 in mouse skin after 5h of application, whereas expression of transglutaminase2 was decreased at this time point.	Tetradecanoylphorbol Acetate	0-3	interleukin 6	Mus musculus	111-124
22842666-3	2012	Pretreatment with pterostilbene has resulted in the reduction of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunits.	Tetradecanoylphorbol Acetate	65-101	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-166
22842666-3	2012	Pretreatment with pterostilbene has resulted in the reduction of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunits.	Tetradecanoylphorbol Acetate	65-101	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	168-176
22842666-3	2012	Pretreatment with pterostilbene has resulted in the reduction of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunits.	Tetradecanoylphorbol Acetate	103-106	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-166
22842666-3	2012	Pretreatment with pterostilbene has resulted in the reduction of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunits.	Tetradecanoylphorbol Acetate	103-106	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	168-176
22842666-4	2012	Pterostilbene also reduced TPA-induced phosphorylation of IkappaBalpha and p65 and caused subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	27-30	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	58-70
22842666-4	2012	Pterostilbene also reduced TPA-induced phosphorylation of IkappaBalpha and p65 and caused subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	27-30	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	116-128
22842666-5	2012	Moreover, pterostilbene markedly suppressed TPA-induced activation of extracellular signal-regulated kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt, which are upstream of NFkappaB and activator protein 1 (AP-1).	Tetradecanoylphorbol Acetate	44-47	mitogen-activated protein kinase 1	Mus musculus	156-160
22842666-5	2012	Moreover, pterostilbene markedly suppressed TPA-induced activation of extracellular signal-regulated kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt, which are upstream of NFkappaB and activator protein 1 (AP-1).	Tetradecanoylphorbol Acetate	44-47	mitogen-activated protein kinase 9	Mus musculus	163-195
22842666-5	2012	Moreover, pterostilbene markedly suppressed TPA-induced activation of extracellular signal-regulated kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt, which are upstream of NFkappaB and activator protein 1 (AP-1).	Tetradecanoylphorbol Acetate	44-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	265-273
22782996-6	2012	Follow-up studies revealed that Tnf, Nfkb1, Il22, Il1b, Cxcl1, Cxcl2 and Cxcl5 mRNAs were highly expressed in epidermis of DBA/2 compared with C57BL/6 mice at 24h following treatment with TPA.	Tetradecanoylphorbol Acetate	188-191	tumor necrosis factor	Mus musculus	32-35
22927445-9	2012	PMA-induced enhancement of STAT3 phosphorylation was observed only in IL-32alpha-expressing cells, and this enhancement was inhibited by Ro-31-8220, but not by Go6976.	Tetradecanoylphorbol Acetate	0-3	signal transducer and activator of transcription 3	Homo sapiens	27-32
22713854-3	2012	hCG or forskolin+PMA induced the transient increase in Runx1, Ptgs2, and Tnfaip6 expression, while the expression of Runx2 continued to increase until 48 h. The knockdown of the agonist-stimulated Runx2 expression increased Runx1, Ptgs2, and Tnfaip6 expression and PGE(2) levels in luteinizing granulosa cells.	Tetradecanoylphorbol Acetate	17-20	RUNX family transcription factor 2	Rattus norvegicus	197-202
22927445-4	2012	We show that phorbol 12-myristate 13-acetate (PMA)-induced increase in IL-6 production by IL-32alpha-expressing cells was higher than that by empty vector-expressing cells and that this increase occurred in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	13-44	interleukin 6	Homo sapiens	71-75
22578170-16	2012	Moreover, IL-31RA and beta-endorphin were increased and colocalized both in AD human skin and TPA-painted mouse skin.	Tetradecanoylphorbol Acetate	94-97	proopiomelanocortin	Homo sapiens	22-36
22927445-4	2012	We show that phorbol 12-myristate 13-acetate (PMA)-induced increase in IL-6 production by IL-32alpha-expressing cells was higher than that by empty vector-expressing cells and that this increase occurred in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	46-49	interleukin 6	Homo sapiens	71-75
22842731-6	2012	RESULTS: In isolated human neutrophils, pinosylvin (10 and 100 mumol/L) significantly decreased the formation of oxidants, both extra- and intracellularly, and effectively inhibited PKC activation stimulated by phorbol myristate acetate (0.05 mumol/L).	Tetradecanoylphorbol Acetate	211-236	proline rich transmembrane protein 2	Homo sapiens	182-185
22644786-7	2012	Adhesion to FN enhanced PMA-stimulated activation of extracellular signal-regulated protein kinase 1 (ERK1)/2 and enforced adhesion to FN via VLA-4 and VLA-5 by TNIIIA2-accelerated activation of ERK1/2 with FN plus PMA.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 3	Homo sapiens	53-100
22644786-7	2012	Adhesion to FN enhanced PMA-stimulated activation of extracellular signal-regulated protein kinase 1 (ERK1)/2 and enforced adhesion to FN via VLA-4 and VLA-5 by TNIIIA2-accelerated activation of ERK1/2 with FN plus PMA.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 3	Homo sapiens	102-106
22644786-7	2012	Adhesion to FN enhanced PMA-stimulated activation of extracellular signal-regulated protein kinase 1 (ERK1)/2 and enforced adhesion to FN via VLA-4 and VLA-5 by TNIIIA2-accelerated activation of ERK1/2 with FN plus PMA.	Tetradecanoylphorbol Acetate	24-27	integrin subunit alpha 5	Homo sapiens	152-157
22644786-7	2012	Adhesion to FN enhanced PMA-stimulated activation of extracellular signal-regulated protein kinase 1 (ERK1)/2 and enforced adhesion to FN via VLA-4 and VLA-5 by TNIIIA2-accelerated activation of ERK1/2 with FN plus PMA.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 3	Homo sapiens	195-201
22926288-4	2012	It has been previously shown that PRP and NP inhibit overproduction of reactive oxygen species, nitric oxide and proinflammatory cytokines induced by lipopolysaccharide or PMA.	Tetradecanoylphorbol Acetate	172-175	prion protein	Homo sapiens	34-37
22892130-5	2012	Several PKC activators, including phorbol 12,13-dibutyrate, 12-O-tetradecanoylphorbol-13-acetate and indolactam V caused upregulation of PKCeta, whereas the general PKC inhibitor Go 6983, but not the conventional PKC inhibitor Go 6976 led to the downregulation of PKCeta.	Tetradecanoylphorbol Acetate	60-96	protein kinase C alpha	Homo sapiens	8-11
22919060-8	2012	The PKC activator, phorbol-12-myristate-13-acetate (PMA), could mimic the induction of COX-2 and CREB1 phosphorylation.	Tetradecanoylphorbol Acetate	19-50	prostaglandin-endoperoxide synthase 2	Homo sapiens	87-92
22919060-8	2012	The PKC activator, phorbol-12-myristate-13-acetate (PMA), could mimic the induction of COX-2 and CREB1 phosphorylation.	Tetradecanoylphorbol Acetate	52-55	prostaglandin-endoperoxide synthase 2	Homo sapiens	87-92
22919060-9	2012	The induction of COX-2 by PGF2alpha and PMA could be attenuated by the small interfering RNA-mediated knockdown of CREB1 expression or overexpressing dominant-negative CREB1.	Tetradecanoylphorbol Acetate	40-43	prostaglandin-endoperoxide synthase 2	Homo sapiens	17-22
22919060-10	2012	A chromatin immunoprecipitation assay showed that the binding of CREB1 to the COX-2 promoter was increased by PGF2alpha and PMA in amnion fibroblasts.	Tetradecanoylphorbol Acetate	124-127	prostaglandin-endoperoxide synthase 2	Homo sapiens	78-83
22954802-2	2012	We investigated the in-vitro function of separated CD3(+)CD4(+)CD25(+)Foxp3(+)IFNgamma(+) PBL that were induced by phorbol-12-myristate-13-acetate(PMA)/Ionomycin or alloantigenic stimulation.	Tetradecanoylphorbol Acetate	115-146	CD4 molecule	Homo sapiens	57-60
22954802-2	2012	We investigated the in-vitro function of separated CD3(+)CD4(+)CD25(+)Foxp3(+)IFNgamma(+) PBL that were induced by phorbol-12-myristate-13-acetate(PMA)/Ionomycin or alloantigenic stimulation.	Tetradecanoylphorbol Acetate	115-146	interferon gamma	Homo sapiens	78-86
22696070-0	2012	Enhancement of protease-induced IL-6 release in monocytic U-937 cells by phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	73-104	interleukin 6	Homo sapiens	32-36
22696070-1	2012	OBJECTIVE AND DESIGN: Serine proteases and phorbol-12-myristate-13-acetate (PMA) are able to induce the release of pro-inflammatory interleukin-6 (IL-6) in monocytic cells.	Tetradecanoylphorbol Acetate	43-74	interleukin 6	Homo sapiens	147-151
22696070-1	2012	OBJECTIVE AND DESIGN: Serine proteases and phorbol-12-myristate-13-acetate (PMA) are able to induce the release of pro-inflammatory interleukin-6 (IL-6) in monocytic cells.	Tetradecanoylphorbol Acetate	76-79	interleukin 6	Homo sapiens	147-151
22773863-0	2012	Inhibiting glycogen synthase kinase-3 decreases 12-O-tetradecanoylphorbol-13-acetate-induced interferon-gamma-mediated skin inflammation.	Tetradecanoylphorbol Acetate	48-84	interferon gamma	Mus musculus	93-109
22773863-2	2012	Because IFN-gamma is involved in inflammatory skin diseases, such as psoriasis, the aim of this study was to investigate the pathogenic role of GSK-3 in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IFN-gamma-mediated ear skin inflammation.	Tetradecanoylphorbol Acetate	153-189	interferon gamma	Mus musculus	204-213
22773863-4	2012	TPA/IFN-gamma induced GSK-3 activation, which in turn activated signal transducer and activator of transcription 1.	Tetradecanoylphorbol Acetate	0-3	interferon gamma	Mus musculus	4-13
22773863-6	2012	It is noteworthy that inhibiting GSK-3 decreased TPA-induced IFN-gamma production and the nuclear translocation of T-box transcription factor Tbx21, a transcription factor of IFN-gamma, in CD3-positive T cells.	Tetradecanoylphorbol Acetate	49-52	interferon gamma	Mus musculus	61-70
22773863-8	2012	These results demonstrate the dual role of GSK-3 in TPA-induced skin inflammation that is not only to facilitate IFN-gamma signaling but also to regulate IFN-gamma production.	Tetradecanoylphorbol Acetate	52-55	interferon gamma	Mus musculus	113-122
22773863-8	2012	These results demonstrate the dual role of GSK-3 in TPA-induced skin inflammation that is not only to facilitate IFN-gamma signaling but also to regulate IFN-gamma production.	Tetradecanoylphorbol Acetate	52-55	interferon gamma	Mus musculus	154-163
22841871-4	2012	Compared to controls, a single topical application of TPA to mouse skin increased the translocation of protein kinase C (PKC) from cytosol to membrane.	Tetradecanoylphorbol Acetate	54-57	protein kinase C, alpha	Mus musculus	121-124
22841871-5	2012	Pretreatment with PBPs 1-3 decreased TPA-induced translocation of PKC isozymes (alpha, beta, eta, gamma, epsilon) from cytosol to membrane, whereas PBPs 4 and 5 were less effective.	Tetradecanoylphorbol Acetate	37-40	protein kinase C, alpha	Mus musculus	66-69
22841871-7	2012	Complementary confocal microscopic evaluation showed a decrease in TPA-induced PKCalpha fluorescence in PBP-3-pretreated membranes, whereas pretreatment with PBP-5 did not show a similar decrease.	Tetradecanoylphorbol Acetate	67-70	protein kinase C, alpha	Mus musculus	79-87
22841871-8	2012	Based on the experiments with specific enzyme inhibitors and phosphospecific antibodies, both PBP-3 and PBP-5 were observed to decrease TPA-induced level and/or activity of phosphatidylinositol 3-kinase (PI3K) and AKT1 (pS473).	Tetradecanoylphorbol Acetate	136-139	thymoma viral proto-oncogene 1	Mus musculus	214-218
22841871-10	2012	Altogether, PBP-mediated decrease in TPA-induced PKC phosphorylation correlated well with decreased TPA-induced NF-kappaB phosphorylation and downstream target proteins associated with proliferation, apoptosis, and inflammation in mouse skin.	Tetradecanoylphorbol Acetate	37-40	protein kinase C, alpha	Mus musculus	49-52
22841871-10	2012	Altogether, PBP-mediated decrease in TPA-induced PKC phosphorylation correlated well with decreased TPA-induced NF-kappaB phosphorylation and downstream target proteins associated with proliferation, apoptosis, and inflammation in mouse skin.	Tetradecanoylphorbol Acetate	100-103	protein kinase C, alpha	Mus musculus	49-52
22964499-8	2012	These changes probably led to the activation of Caspase-3 protein and apoptosis cell death occurred in MCF-7 and HeLa cell lines upon 24 h treatment with PEs and PMA.	Tetradecanoylphorbol Acetate	162-165	caspase 3	Homo sapiens	48-57
22892130-5	2012	Several PKC activators, including phorbol 12,13-dibutyrate, 12-O-tetradecanoylphorbol-13-acetate and indolactam V caused upregulation of PKCeta, whereas the general PKC inhibitor Go 6983, but not the conventional PKC inhibitor Go 6976 led to the downregulation of PKCeta.	Tetradecanoylphorbol Acetate	60-96	protein kinase C alpha	Homo sapiens	137-140
22892130-5	2012	Several PKC activators, including phorbol 12,13-dibutyrate, 12-O-tetradecanoylphorbol-13-acetate and indolactam V caused upregulation of PKCeta, whereas the general PKC inhibitor Go 6983, but not the conventional PKC inhibitor Go 6976 led to the downregulation of PKCeta.	Tetradecanoylphorbol Acetate	60-96	protein kinase C alpha	Homo sapiens	137-140
22974092-8	2012	The baseline values of CEA, TPA and TIMP-1 were also significantly correlated to PFS and TPA to RR.	Tetradecanoylphorbol Acetate	89-92	CEA cell adhesion molecule 3	Homo sapiens	23-26
22905650-8	2012	Complex 1a was successively converted into an intermediate [Co(III)(TPA)(CysOMe-H)](2+), 1d, by exchange of the hydroximate with the cysteinate ligand, and further into Co(III)(CysOMe-H)(3), 5.	Tetradecanoylphorbol Acetate	68-71	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	60-67
22905650-8	2012	Complex 1a was successively converted into an intermediate [Co(III)(TPA)(CysOMe-H)](2+), 1d, by exchange of the hydroximate with the cysteinate ligand, and further into Co(III)(CysOMe-H)(3), 5.	Tetradecanoylphorbol Acetate	68-71	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	169-176
22921746-0	2012	Curcumin suppresses the TPA-induced invasion through inhibition of PKCalpha-dependent MMP-expression in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	24-27	protein kinase C alpha	Homo sapiens	67-75
22921746-6	2012	Also, curcumin strongly repressed the TPA-induced phosphorylation of p38 and JNK and inhibited TPA-induced translocation of PKCalpha from the cytosol to the membrane, but did not affect the translocation of PKCdelta.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase 14	Homo sapiens	69-72
22921746-6	2012	Also, curcumin strongly repressed the TPA-induced phosphorylation of p38 and JNK and inhibited TPA-induced translocation of PKCalpha from the cytosol to the membrane, but did not affect the translocation of PKCdelta.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase 8	Homo sapiens	77-80
22921746-6	2012	Also, curcumin strongly repressed the TPA-induced phosphorylation of p38 and JNK and inhibited TPA-induced translocation of PKCalpha from the cytosol to the membrane, but did not affect the translocation of PKCdelta.	Tetradecanoylphorbol Acetate	95-98	protein kinase C alpha	Homo sapiens	124-132
22921746-7	2012	These results indicate that curcumin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKCalpha, MAPK and NF-kappaB/AP-1 pathway in MCF-7 cells.	Tetradecanoylphorbol Acetate	60-63	protein kinase C alpha	Homo sapiens	139-147
22974092-8	2012	The baseline values of CEA, TPA and TIMP-1 were also significantly correlated to PFS and TPA to RR.	Tetradecanoylphorbol Acetate	89-92	TIMP metallopeptidase inhibitor 1	Homo sapiens	36-42
22977714-0	2012	Phorbol 12-Myristate 13-Acetate Induces MUC16 Expression via PKCdelta and p38 in Human Airway Epithelial Cells.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 1	Homo sapiens	74-77
22977714-8	2012	SB203580 (p38 MAPK inhibitor) inhibited PMA-induced MUC16 expression, while U0126 (ERK1/2 inhibitor) did not.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 1	Homo sapiens	10-13
22578382-9	2012	A constitutively active mutant of CaMKII activated a luciferase reporter plasmid under the control of MEF2, when cotransfected in T lymphocytes stimulated by Ionomycin and PMA, whereas its inhibitor KN-62 inhibited MEF2 binding in cell lysates of the same cells.	Tetradecanoylphorbol Acetate	172-175	myocyte enhancer factor 2C	Mus musculus	102-106
22441738-6	2012	Inhibitors of 12-LOX, but not those of COX, 5-LOX or 15-LOX, reduce MUC5AC expression induced by phorbol myristate acetate (PMA) in the bronchial epithelial cell line NCI-H292.	Tetradecanoylphorbol Acetate	97-122	arachidonate 15-lipoxygenase	Homo sapiens	14-20
22441738-6	2012	Inhibitors of 12-LOX, but not those of COX, 5-LOX or 15-LOX, reduce MUC5AC expression induced by phorbol myristate acetate (PMA) in the bronchial epithelial cell line NCI-H292.	Tetradecanoylphorbol Acetate	124-127	arachidonate 15-lipoxygenase	Homo sapiens	14-20
22700433-5	2012	15d-PGJ2-G treatment decreased phorbol 12-myristate 13-acetate (PMA)/calcium ionophore (I0)-induced NFAT DNA binding to the human IL-2 promoter and nuclear NFAT2 accumulation.	Tetradecanoylphorbol Acetate	31-62	interleukin 2	Homo sapiens	130-134
22700433-5	2012	15d-PGJ2-G treatment decreased phorbol 12-myristate 13-acetate (PMA)/calcium ionophore (I0)-induced NFAT DNA binding to the human IL-2 promoter and nuclear NFAT2 accumulation.	Tetradecanoylphorbol Acetate	64-67	interleukin 2	Homo sapiens	130-134
22733205-4	2012	We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells.	Tetradecanoylphorbol Acetate	49-74	interleukin 10	Mus musculus	131-136
22643241-3	2012	Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed.	Tetradecanoylphorbol Acetate	31-62	taste 2 receptor member 64 pseudogene	Homo sapiens	278-281
22643241-3	2012	Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed.	Tetradecanoylphorbol Acetate	64-67	taste 2 receptor member 64 pseudogene	Homo sapiens	278-281
22583821-2	2012	CNP mRNA is up-regulated in human vascular smooth muscle cells (SMC) by PDGF-BB via a protein kinase C (PKC)-dependent pathways, and by general PKC activation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	164-189	protein kinase C alpha	Homo sapiens	144-147
22583821-2	2012	CNP mRNA is up-regulated in human vascular smooth muscle cells (SMC) by PDGF-BB via a protein kinase C (PKC)-dependent pathways, and by general PKC activation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	191-194	protein kinase C alpha	Homo sapiens	144-147
22583821-10	2012	A 8-10-fold greater PMA-induced increase in CNP transcript in SMC than in HAEC suggests that smooth muscle cells could be selectively targeted for CNP up-regulation by PKC-alpha- and PKC-delta-activators.	Tetradecanoylphorbol Acetate	20-23	protein kinase C alpha	Homo sapiens	168-177
22513115-4	2012	In human primary T and Jurkat E6.1 cells, both CD3/CD28 and PMA/Ionomycin induced NF-kappaB activation showed a para-curve correlation with the dosage of small interfering RNA targeting NEMO (siNEMO): the NF-kappaB report gene activity was increased along with ascending doses of transfected siNEMO and reached the highest activity when knockdown about 70% of NEMO, then turned to decline and gradually be blocked once almost thoroughly knockdown of NEMO.	Tetradecanoylphorbol Acetate	60-63	nuclear factor kappa B subunit 1	Homo sapiens	82-91
22513115-4	2012	In human primary T and Jurkat E6.1 cells, both CD3/CD28 and PMA/Ionomycin induced NF-kappaB activation showed a para-curve correlation with the dosage of small interfering RNA targeting NEMO (siNEMO): the NF-kappaB report gene activity was increased along with ascending doses of transfected siNEMO and reached the highest activity when knockdown about 70% of NEMO, then turned to decline and gradually be blocked once almost thoroughly knockdown of NEMO.	Tetradecanoylphorbol Acetate	60-63	nuclear factor kappa B subunit 1	Homo sapiens	205-214
22775995-5	2012	The COL17-deficient cells showed an abnormally high IL-8 response after treatment with lipopolysaccharide (LPS), ultraviolet-B radiation or tumor necrosis factor, but exhibited a blunted IL-8 response to phorbol 12-myristate 13-acetate exposure.	Tetradecanoylphorbol Acetate	204-235	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
22316125-7	2012	PKC activator phorbol 12-myristate 13-acetate enhanced EGFR tyrosyl phosphorylation and upregulated the gene expression of growth factors and cytokines in a heparin-binding EGF-like growth factor (HBEGF) inhibitor CRM197 sensitive manner, indicating an involvement of autocrined HBEGF in the downstream of PKC signaling.	Tetradecanoylphorbol Acetate	14-45	epidermal growth factor receptor	Homo sapiens	55-59
22617836-8	2012	CCK/TPA stimulated the association of Yes with focal adhesion kinases (Pyk2, FAK) and its autophosphorylated forms (pY397FAK, pY402Pyk2).	Tetradecanoylphorbol Acetate	4-7	protein tyrosine kinase 2 beta	Rattus norvegicus	71-75
22617836-9	2012	Moreover, CCK/TPA stimulated Yes interacted with a number of other signaling proteins, including Shc, PKD, p130(Cas), PI3K and PTEN.	Tetradecanoylphorbol Acetate	14-17	phospholipase C-like 1	Rattus norvegicus	107-111
22533343-4	2012	Our studies demonstrate that both the tumor promoter TPA and UVC irradiation decreased expression and activity levels of IDH1, not IDH2, in the tumor promotable JB6 P+ cell model.	Tetradecanoylphorbol Acetate	53-56	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	131-135
22736279-7	2012	We have observed that the production of soluble hCLEC-2 could be induced by phorbol ester (PMA) in cells stably transfected with hCLEC-2 cDNA.	Tetradecanoylphorbol Acetate	91-94	C-type lectin domain family 1 member B	Homo sapiens	48-55
22736279-7	2012	We have observed that the production of soluble hCLEC-2 could be induced by phorbol ester (PMA) in cells stably transfected with hCLEC-2 cDNA.	Tetradecanoylphorbol Acetate	91-94	C-type lectin domain family 1 member B	Homo sapiens	129-136
22733205-4	2012	We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells.	Tetradecanoylphorbol Acetate	76-79	interleukin 10	Mus musculus	131-136
22733205-5	2012	In addition, scopoletin significantly enhanced the inhibitory action of PMA/ionomycin on interferon-gamma (IFN-gamma) expression.	Tetradecanoylphorbol Acetate	72-75	interferon gamma	Mus musculus	89-105
22733205-5	2012	In addition, scopoletin significantly enhanced the inhibitory action of PMA/ionomycin on interferon-gamma (IFN-gamma) expression.	Tetradecanoylphorbol Acetate	72-75	interferon gamma	Mus musculus	107-116
22170686-2	2012	In the present study, 12-O-tetradecanoylphorbol-13-acetate (TPA) addition significantly inhibited GOS-induced apoptosis in human colorectal carcinoma HT-29 cells in accordance with inducing COX-2 protein/PGE(2) production.	Tetradecanoylphorbol Acetate	22-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
22170686-2	2012	In the present study, 12-O-tetradecanoylphorbol-13-acetate (TPA) addition significantly inhibited GOS-induced apoptosis in human colorectal carcinoma HT-29 cells in accordance with inducing COX-2 protein/PGE(2) production.	Tetradecanoylphorbol Acetate	60-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	190-195
22415432-6	2012	After stimulation with PMA and ionomycin, gammadelta T cells from HBV-ACLF patients produced the greatest amount of TNF-alpha or IL-17 among the three groups.	Tetradecanoylphorbol Acetate	23-26	tumor necrosis factor	Homo sapiens	116-125
22170686-3	2012	TPA inhibition of GOS-induced apoptosis was blocked by adding protein kinase (PK)C inhibitors including staurosporine (ST), GF109203X (GF), and H7, characterized by the occurrence of cleaved caspase 3 proteins and a decrease in COX-2 protein/PGE(2) production in HT-29 cells.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-233
22696685-3	2012	We show that treatment with a combination of phorbol 12-myristate 13-acetate (PMA) plus ionophore A23187 (Io), which induces NFAT activation, increased REDD1 mRNA and protein expression and inhibited mTOR signaling; pretreatment with the calcineurin inhibitor cyclosporin A (CsA), an antagonist of NFAT signaling, decreased REDD1 induction and mTOR inhibition.	Tetradecanoylphorbol Acetate	45-76	mechanistic target of rapamycin kinase	Homo sapiens	200-204
22562304-4	2012	Intriguingly, Pin1(+/+) mouse embryonic fibroblasts (MEFs) exhibited significantly an increase in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced RSK2 phosphorylation with a marginal Pin1 phosphorylation compared with Pin1(-/-) MEFs.	Tetradecanoylphorbol Acetate	98-134	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	14-18
22562304-4	2012	Intriguingly, Pin1(+/+) mouse embryonic fibroblasts (MEFs) exhibited significantly an increase in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced RSK2 phosphorylation with a marginal Pin1 phosphorylation compared with Pin1(-/-) MEFs.	Tetradecanoylphorbol Acetate	136-139	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	14-18
22562304-4	2012	Intriguingly, Pin1(+/+) mouse embryonic fibroblasts (MEFs) exhibited significantly an increase in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced RSK2 phosphorylation with a marginal Pin1 phosphorylation compared with Pin1(-/-) MEFs.	Tetradecanoylphorbol Acetate	136-139	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	186-190
22562304-4	2012	Intriguingly, Pin1(+/+) mouse embryonic fibroblasts (MEFs) exhibited significantly an increase in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced RSK2 phosphorylation with a marginal Pin1 phosphorylation compared with Pin1(-/-) MEFs.	Tetradecanoylphorbol Acetate	136-139	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	186-190
22696685-3	2012	We show that treatment with a combination of phorbol 12-myristate 13-acetate (PMA) plus ionophore A23187 (Io), which induces NFAT activation, increased REDD1 mRNA and protein expression and inhibited mTOR signaling; pretreatment with the calcineurin inhibitor cyclosporin A (CsA), an antagonist of NFAT signaling, decreased REDD1 induction and mTOR inhibition.	Tetradecanoylphorbol Acetate	45-76	mechanistic target of rapamycin kinase	Homo sapiens	344-348
22696685-3	2012	We show that treatment with a combination of phorbol 12-myristate 13-acetate (PMA) plus ionophore A23187 (Io), which induces NFAT activation, increased REDD1 mRNA and protein expression and inhibited mTOR signaling; pretreatment with the calcineurin inhibitor cyclosporin A (CsA), an antagonist of NFAT signaling, decreased REDD1 induction and mTOR inhibition.	Tetradecanoylphorbol Acetate	78-81	mechanistic target of rapamycin kinase	Homo sapiens	200-204
22696685-3	2012	We show that treatment with a combination of phorbol 12-myristate 13-acetate (PMA) plus ionophore A23187 (Io), which induces NFAT activation, increased REDD1 mRNA and protein expression and inhibited mTOR signaling; pretreatment with the calcineurin inhibitor cyclosporin A (CsA), an antagonist of NFAT signaling, decreased REDD1 induction and mTOR inhibition.	Tetradecanoylphorbol Acetate	78-81	mechanistic target of rapamycin kinase	Homo sapiens	344-348
22685300-4	2012	In cultured mouse hepatocytes, APPL1 phosphorylation at Ser(430) is stimulated by phorbol 12-myristate 13-acetate, an activator of classic PKC isoforms, and by the endoplasmic reticulum (ER) stress inducer, thapsigargin.	Tetradecanoylphorbol Acetate	82-113	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	Mus musculus	31-36
22685300-4	2012	In cultured mouse hepatocytes, APPL1 phosphorylation at Ser(430) is stimulated by phorbol 12-myristate 13-acetate, an activator of classic PKC isoforms, and by the endoplasmic reticulum (ER) stress inducer, thapsigargin.	Tetradecanoylphorbol Acetate	82-113	protein kinase C, alpha	Mus musculus	139-142
22445541-3	2012	Here, we showed that staphylococcal LTA (Sa.LTA) substantially enhanced IL-6 expression at both the protein and the mRNA levels in the human basophil line, KU812, in the presence of a PKC activator (phorbol 12-myristrate 13-acetate; PMA), and a calcium ionophore (A23187), whereas Sa.LTA alone could not induce IL-6 expression.	Tetradecanoylphorbol Acetate	233-236	interleukin 6	Homo sapiens	72-76
22658257-6	2012	SAB reduced modified LDL (mLDL) uptake in a dose-dependent manner in phorbol-12-myristate-13-acetate (PMA)-stimulated THP-1 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	69-100	SH3 domain binding protein 5	Homo sapiens	0-3
22658257-6	2012	SAB reduced modified LDL (mLDL) uptake in a dose-dependent manner in phorbol-12-myristate-13-acetate (PMA)-stimulated THP-1 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	69-100	GLI family zinc finger 2	Homo sapiens	118-123
22658257-6	2012	SAB reduced modified LDL (mLDL) uptake in a dose-dependent manner in phorbol-12-myristate-13-acetate (PMA)-stimulated THP-1 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	102-105	SH3 domain binding protein 5	Homo sapiens	0-3
22658257-6	2012	SAB reduced modified LDL (mLDL) uptake in a dose-dependent manner in phorbol-12-myristate-13-acetate (PMA)-stimulated THP-1 and RAW 264.7 cells.	Tetradecanoylphorbol Acetate	102-105	GLI family zinc finger 2	Homo sapiens	118-123
22728857-7	2012	RESULTS: Mean ADC/CSF for PA and PMA was 0.53+-0.10 and 0.69+-0.10 (p&lt;0.01).	Tetradecanoylphorbol Acetate	33-36	laminin subunit gamma 2	Homo sapiens	18-21
22728857-8	2012	Mean T2/CSF for PA and PMA was 0.78+-0.19 and 0.93+-0.09 (p&lt;0.01).	Tetradecanoylphorbol Acetate	23-26	laminin subunit gamma 2	Homo sapiens	5-11
22364122-7	2012	F3 inhibited NO, inducible nitric oxide synthetase (iNOS), and IL-8 in interferon gamma (IFN-gamma)- and phorbol ester (PMA)-induced Caco-2 cells.	Tetradecanoylphorbol Acetate	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
22570253-8	2012	These CD137+PD-1High CD8+ T cells, persisted in irradiated AT-3 tumors, expressed Tim-3, granzyme B and Ki67 and produced IFN-gamma ex vivo in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin stimulation.	Tetradecanoylphorbol Acetate	155-186	tumor necrosis factor receptor superfamily, member 9	Mus musculus	6-11
22570253-8	2012	These CD137+PD-1High CD8+ T cells, persisted in irradiated AT-3 tumors, expressed Tim-3, granzyme B and Ki67 and produced IFN-gamma ex vivo in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin stimulation.	Tetradecanoylphorbol Acetate	188-191	tumor necrosis factor receptor superfamily, member 9	Mus musculus	6-11
22505472-4	2012	We found that exosomal ADAM15 release is stimulated by phorbol 12-myristate 13-acetate, a typical protein kinase C activator, in various tumor cell types, and this results in a corresponding decrease in plasma membrane-associated ADAM15.	Tetradecanoylphorbol Acetate	55-86	ADAM metallopeptidase domain 15	Homo sapiens	23-29
22716246-9	2012	Moreover, a dramatic increase in GnT-V expression was observed by treatment with TPA or heparin-binding EGF-like growth factor (HB-EGF) in normal human epidermal keratinocytes.	Tetradecanoylphorbol Acetate	81-84	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	33-38
22597534-7	2012	Deletion and mutation analysis of human LOX-1 promoter-luciferase constructs transfected into HAEC with an androgen receptor (AR) expression plasmid revealed that the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (TRE; nucleotides -60/-53) contributed to the inhibitory effects of DHT on TNFalpha-induced LOX-1 expression.	Tetradecanoylphorbol Acetate	167-203	androgen receptor	Homo sapiens	107-124
22597534-7	2012	Deletion and mutation analysis of human LOX-1 promoter-luciferase constructs transfected into HAEC with an androgen receptor (AR) expression plasmid revealed that the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (TRE; nucleotides -60/-53) contributed to the inhibitory effects of DHT on TNFalpha-induced LOX-1 expression.	Tetradecanoylphorbol Acetate	167-203	androgen receptor	Homo sapiens	126-128
22597534-7	2012	Deletion and mutation analysis of human LOX-1 promoter-luciferase constructs transfected into HAEC with an androgen receptor (AR) expression plasmid revealed that the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (TRE; nucleotides -60/-53) contributed to the inhibitory effects of DHT on TNFalpha-induced LOX-1 expression.	Tetradecanoylphorbol Acetate	167-203	tumor necrosis factor	Homo sapiens	302-310
22672985-8	2012	In CDDP-resistant cells, CDDP and PMA dramatically suppressed the cell growth, up-regulated the expression of phosphorylated ERK and cleaved caspase-9, down-regulated the expression of checkpoint kinases, and increased the proportion of cells in the synthesis-phase fraction and apoptotic cells.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 1	Homo sapiens	125-128
22542552-0	2012	Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-kappaB, C/EBP and AP-1 signaling pathways in murine macrophages.	Tetradecanoylphorbol Acetate	18-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	81-90
22542552-6	2012	In addition, piperine inhibited PMA-induced NF-kappaB, C/EBP and c-Jun nuclear translocation.	Tetradecanoylphorbol Acetate	32-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-53
22542552-7	2012	Furthermore, piperine significantly inhibited PMA-induced activation of the Akt and ERK.	Tetradecanoylphorbol Acetate	46-49	thymoma viral proto-oncogene 1	Mus musculus	76-79
22542552-7	2012	Furthermore, piperine significantly inhibited PMA-induced activation of the Akt and ERK.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 1	Mus musculus	84-87
22773582-0	2012	Sorafenib inhibits TPA-induced MMP-9 and VEGF expression via suppression of ERK/NF-kappaB pathway in hepatocellular carcinoma cells.	Tetradecanoylphorbol Acetate	19-22	vascular endothelial growth factor A	Homo sapiens	41-45
22773582-0	2012	Sorafenib inhibits TPA-induced MMP-9 and VEGF expression via suppression of ERK/NF-kappaB pathway in hepatocellular carcinoma cells.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase 1	Homo sapiens	76-79
22773582-0	2012	Sorafenib inhibits TPA-induced MMP-9 and VEGF expression via suppression of ERK/NF-kappaB pathway in hepatocellular carcinoma cells.	Tetradecanoylphorbol Acetate	19-22	nuclear factor kappa B subunit 1	Homo sapiens	80-89
22773582-4	2012	TPA increased the NF-kappaB activity and the expressions of MMP-9 and VEGF significantly, but its effects were suppressed by sorafenib in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	18-27
22773582-4	2012	TPA increased the NF-kappaB activity and the expressions of MMP-9 and VEGF significantly, but its effects were suppressed by sorafenib in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-3	vascular endothelial growth factor A	Homo sapiens	70-74
22773582-6	2012	Furthermore, transfection of Huh7 cell with an inhibitor of kappaB-alpha mutant vector, led to reduced TPA-induced MMP-9 and VEGF mRNA expressions.	Tetradecanoylphorbol Acetate	103-106	vascular endothelial growth factor A	Homo sapiens	125-129
22773582-7	2012	Sorafenib inhibits TPA-induced MMP-9 and VEGF expressions via the suppression of ERK/NF-kappaB pathway in HCC cells.	Tetradecanoylphorbol Acetate	19-22	vascular endothelial growth factor A	Homo sapiens	41-45
22773582-7	2012	Sorafenib inhibits TPA-induced MMP-9 and VEGF expressions via the suppression of ERK/NF-kappaB pathway in HCC cells.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase 1	Homo sapiens	81-84
22773582-7	2012	Sorafenib inhibits TPA-induced MMP-9 and VEGF expressions via the suppression of ERK/NF-kappaB pathway in HCC cells.	Tetradecanoylphorbol Acetate	19-22	nuclear factor kappa B subunit 1	Homo sapiens	85-94
22381172-0	2012	Berberine suppresses the TPA-induced MMP-1 and MMP-9 expressions through the inhibition of PKC-alpha in breast cancer cells.	Tetradecanoylphorbol Acetate	25-28	protein kinase C alpha	Homo sapiens	91-100
22505246-5	2012	Juglone significantly suppressed TPA-induced protein kinase B (AKT) and c-Jun phosphorylation and c-fos activation, but not mitogen-activated protein-kinase kinase (MEK), extracellular signaling-regulated kinase (ERK) or 90 kDa ribosomal protein S6 kinase (RSK) phosphorylation.	Tetradecanoylphorbol Acetate	33-36	AKT serine/threonine kinase 1	Homo sapiens	63-66
22505246-5	2012	Juglone significantly suppressed TPA-induced protein kinase B (AKT) and c-Jun phosphorylation and c-fos activation, but not mitogen-activated protein-kinase kinase (MEK), extracellular signaling-regulated kinase (ERK) or 90 kDa ribosomal protein S6 kinase (RSK) phosphorylation.	Tetradecanoylphorbol Acetate	33-36	ribosomal protein S6 kinase A2	Homo sapiens	228-255
22505246-5	2012	Juglone significantly suppressed TPA-induced protein kinase B (AKT) and c-Jun phosphorylation and c-fos activation, but not mitogen-activated protein-kinase kinase (MEK), extracellular signaling-regulated kinase (ERK) or 90 kDa ribosomal protein S6 kinase (RSK) phosphorylation.	Tetradecanoylphorbol Acetate	33-36	ribosomal protein S6 kinase A2	Homo sapiens	257-260
22418867-5	2012	12-O-tetradecanoylphorbol-13-acetate-induced increase in cell survival activity and nuclear translocation of STAT3 was associated with Ser727 phosphorylation.	Tetradecanoylphorbol Acetate	0-36	signal transducer and activator of transcription 3	Homo sapiens	109-114
22381172-11	2012	In addition, the TPA-induced MMP-1 and MMP-9 expressions were completely decreased by Go6983 and PKC-alpha siRNA, respectively.	Tetradecanoylphorbol Acetate	17-20	protein kinase C alpha	Homo sapiens	97-106
22381172-12	2012	TPA-induced PKC-alpha phosphorylation was dose-dependently decreased by BBR treatment.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	12-21
22381172-13	2012	CONCLUSION: The TPA-induced PKC-alpha phosphorylation is suppressed and then the MMP-1 and MMP-9 expressions are also inhibited by berberine.	Tetradecanoylphorbol Acetate	16-19	protein kinase C alpha	Homo sapiens	28-37
22615491-5	2012	SPF45 was differentially phosphorylated in cells by all three mitogen-activated protein (MAP) kinases in response to phorbol myristate acid (PMA), H(2)O(2), UV, and anisomycin stimulation.	Tetradecanoylphorbol Acetate	141-144	RNA binding motif protein 17	Homo sapiens	0-5
22465218-8	2012	Further mechanistic studies demonstrated that mangiferin inhibits the binding of NF-kappaB and AP-1 to the MMP-9 promoter and suppresses the PMA-induced phosphorylation of Akt and MAP kinases, which are upstream signaling molecules in MMP-9 expression.	Tetradecanoylphorbol Acetate	141-144	AKT serine/threonine kinase 1	Homo sapiens	172-175
22609207-0	2012	Regulation of the alternative splicing of sarcoplasmic reticulum Ca2+-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway.	Tetradecanoylphorbol Acetate	90-121	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	79-85
23156739-7	2012	AGE-HSA up-regulated the expression of FN mRAN and protein in dose- and time-dependently (P &lt; 0.01); PKC activator phorbol 12-myristate 13-acetate (PMA) induced FN expression, respectively depletion of PKC and calphostin C, a PKC inhibitor, effectively prevented both PMA and AGE-HSA-induced expression of the FN (P &lt; 0.05).	Tetradecanoylphorbol Acetate	118-149	fibronectin 1	Homo sapiens	39-41
23156739-7	2012	AGE-HSA up-regulated the expression of FN mRAN and protein in dose- and time-dependently (P &lt; 0.01); PKC activator phorbol 12-myristate 13-acetate (PMA) induced FN expression, respectively depletion of PKC and calphostin C, a PKC inhibitor, effectively prevented both PMA and AGE-HSA-induced expression of the FN (P &lt; 0.05).	Tetradecanoylphorbol Acetate	118-149	fibronectin 1	Homo sapiens	164-166
23156739-7	2012	AGE-HSA up-regulated the expression of FN mRAN and protein in dose- and time-dependently (P &lt; 0.01); PKC activator phorbol 12-myristate 13-acetate (PMA) induced FN expression, respectively depletion of PKC and calphostin C, a PKC inhibitor, effectively prevented both PMA and AGE-HSA-induced expression of the FN (P &lt; 0.05).	Tetradecanoylphorbol Acetate	118-149	fibronectin 1	Homo sapiens	164-166
22561169-4	2012	Mn2+ at 0.1-1 mM did not significantly induce IL-2 production, whereas phorbol 12-myristate 13-acetate (PMA) at 1 muM slightly induced IL-2 production.	Tetradecanoylphorbol Acetate	71-102	interleukin 2	Homo sapiens	135-139
22561169-4	2012	Mn2+ at 0.1-1 mM did not significantly induce IL-2 production, whereas phorbol 12-myristate 13-acetate (PMA) at 1 muM slightly induced IL-2 production.	Tetradecanoylphorbol Acetate	104-107	interleukin 2	Homo sapiens	135-139
22561169-8	2012	These results suggest that Mn2+ promotes PMA-induced IL-2 production by inducing the production and activation of AP-1, at least in part.	Tetradecanoylphorbol Acetate	41-44	interleukin 2	Homo sapiens	53-57
22504225-4	2012	We previously used TPA to show that both dystrophin and utrophin have a paradoxical effect on actin rotational dynamics-restricting amplitude while increasing rate, thus increasing resilience, with utrophin more effective than dystrophin.	Tetradecanoylphorbol Acetate	19-22	dystrophin, muscular dystrophy	Mus musculus	41-51
22504225-4	2012	We previously used TPA to show that both dystrophin and utrophin have a paradoxical effect on actin rotational dynamics-restricting amplitude while increasing rate, thus increasing resilience, with utrophin more effective than dystrophin.	Tetradecanoylphorbol Acetate	19-22	utrophin	Mus musculus	56-64
22504225-10	2012	Resilience of the actin-protein complex, measured by TPA, correlates remarkably well with previous reports of functional rescue by dystrophin and utrophin constructs in mdx mice.	Tetradecanoylphorbol Acetate	53-56	utrophin	Mus musculus	146-154
22609207-0	2012	Regulation of the alternative splicing of sarcoplasmic reticulum Ca2+-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway.	Tetradecanoylphorbol Acetate	123-126	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	79-85
22609207-5	2012	By assessing the splicing pattern of the endogenous SERCA1 gene in HEK293 cells, we found that treatment with phorbol 12-myristate 13-acetate (PMA) regulated SERCA1 splicing.	Tetradecanoylphorbol Acetate	110-141	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	52-58
22609207-5	2012	By assessing the splicing pattern of the endogenous SERCA1 gene in HEK293 cells, we found that treatment with phorbol 12-myristate 13-acetate (PMA) regulated SERCA1 splicing.	Tetradecanoylphorbol Acetate	110-141	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	158-164
22609207-5	2012	By assessing the splicing pattern of the endogenous SERCA1 gene in HEK293 cells, we found that treatment with phorbol 12-myristate 13-acetate (PMA) regulated SERCA1 splicing.	Tetradecanoylphorbol Acetate	143-146	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	52-58
22609207-5	2012	By assessing the splicing pattern of the endogenous SERCA1 gene in HEK293 cells, we found that treatment with phorbol 12-myristate 13-acetate (PMA) regulated SERCA1 splicing.	Tetradecanoylphorbol Acetate	143-146	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	158-164
22609207-6	2012	Interestingly, treatment with PMA for 48 h normalized SERCA1 splicing, while treatment for 1.5h promoted aberrant splicing.	Tetradecanoylphorbol Acetate	30-33	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	54-60
22511759-5	2012	Despite these data, the levels of the transcripts that encode the proinflammatory cytokines IL-1beta and TNF-alpha were reduced in phorbol 12-myristate 13-acetate-treated MCs developed from RasGRP4-null mice.	Tetradecanoylphorbol Acetate	131-162	interleukin 1 beta	Mus musculus	92-100
22511759-5	2012	Despite these data, the levels of the transcripts that encode the proinflammatory cytokines IL-1beta and TNF-alpha were reduced in phorbol 12-myristate 13-acetate-treated MCs developed from RasGRP4-null mice.	Tetradecanoylphorbol Acetate	131-162	tumor necrosis factor	Mus musculus	105-114
22732221-0	2012	Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein.	Tetradecanoylphorbol Acetate	15-51	annexin A11, opposite strand	Mus musculus	110-117
22732221-4	2012	The results indicate that Tat-ANX1 protein inhibits the inflammatory response by blocking NF-kappa B and MAPK activation in TPA-induced mice ears.	Tetradecanoylphorbol Acetate	124-127	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-100
22732221-0	2012	Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein.	Tetradecanoylphorbol Acetate	53-56	annexin A11, opposite strand	Mus musculus	110-117
22770404-9	2012	Similarly, when ADAM10 was suppressed by short hairpin RNA, CD16b shedding was decreased after stimulation with ionomycin; when ADAM17 was suppressed by short hairpin RNA, CD16b shedding was decreased after stimulation with PMA.	Tetradecanoylphorbol Acetate	224-227	a disintegrin and metallopeptidase domain 17	Mus musculus	128-134
22330070-2	2012	T cell activation by T cell receptor (TCR) engagement or its pharmacological mimics, PMA plus ionomycin (PMA/Io), induces immunomodulatory FasL and cyclooxygenase-2 (COX-2) expression.	Tetradecanoylphorbol Acetate	85-88	prostaglandin-endoperoxide synthase 2	Homo sapiens	148-164
22330070-2	2012	T cell activation by T cell receptor (TCR) engagement or its pharmacological mimics, PMA plus ionomycin (PMA/Io), induces immunomodulatory FasL and cyclooxygenase-2 (COX-2) expression.	Tetradecanoylphorbol Acetate	85-88	prostaglandin-endoperoxide synthase 2	Homo sapiens	166-171
22330070-2	2012	T cell activation by T cell receptor (TCR) engagement or its pharmacological mimics, PMA plus ionomycin (PMA/Io), induces immunomodulatory FasL and cyclooxygenase-2 (COX-2) expression.	Tetradecanoylphorbol Acetate	105-108	prostaglandin-endoperoxide synthase 2	Homo sapiens	148-164
22330070-2	2012	T cell activation by T cell receptor (TCR) engagement or its pharmacological mimics, PMA plus ionomycin (PMA/Io), induces immunomodulatory FasL and cyclooxygenase-2 (COX-2) expression.	Tetradecanoylphorbol Acetate	105-108	prostaglandin-endoperoxide synthase 2	Homo sapiens	166-171
22491752-11	2012	Moreover, KLF4 knockout led to increased cell proliferation and skin carcinogenesis in a classical DMBA/TPA mouse skin cancer model.	Tetradecanoylphorbol Acetate	104-107	Kruppel-like factor 4 (gut)	Mus musculus	10-14
22207689-7	2012	Regulated secretion of von Willebrand factor was induced by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	60-91	von Willebrand factor	Homo sapiens	23-44
22009527-5	2012	When these cell lines were primed with CXC chemokine ligand 8 (IL-8), a slight increase in reactive oxygen species production induced by phorbol myristate acetate (PMA) or zymosan A stimuli was observed.	Tetradecanoylphorbol Acetate	137-162	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
22160839-4	2012	Th1 and Th2 cells, levels of INF-gamma, IL-2, IL-4 and the activities of T-bet and GATA3 were significantly increased after incubation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	140-143	interleukin 2	Homo sapiens	40-44
22160839-4	2012	Th1 and Th2 cells, levels of INF-gamma, IL-2, IL-4 and the activities of T-bet and GATA3 were significantly increased after incubation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	140-143	interleukin 4	Homo sapiens	46-50
22160839-5	2012	However, the number of Th1 cells, Th1/ Th2, the levels of INF-gamma and INF-gamma/IL-4, and the activities and protein levels of T-bet and GATA3 were decreased after incubation with PMA and ionomycin in the presence of morphine.	Tetradecanoylphorbol Acetate	182-185	interleukin 4	Homo sapiens	82-86
21981079-3	2012	In this study, we evaluated the anti-inflammatory activity of Arisaema cum Bile extract on lipopolysaccharide (LPS)-induced inflammation in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages.	Tetradecanoylphorbol Acetate	140-171	GLI family zinc finger 2	Homo sapiens	193-198
21981079-3	2012	In this study, we evaluated the anti-inflammatory activity of Arisaema cum Bile extract on lipopolysaccharide (LPS)-induced inflammation in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages.	Tetradecanoylphorbol Acetate	173-176	GLI family zinc finger 2	Homo sapiens	193-198
22009527-5	2012	When these cell lines were primed with CXC chemokine ligand 8 (IL-8), a slight increase in reactive oxygen species production induced by phorbol myristate acetate (PMA) or zymosan A stimuli was observed.	Tetradecanoylphorbol Acetate	164-167	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
22967443-12	2012	After treatment with NAL and PMA, the values of A570 and p-PKC protein levels were elevated significantly (P &lt; 0.01).	Tetradecanoylphorbol Acetate	29-32	proline rich transmembrane protein 2	Homo sapiens	59-62
22505712-6	2012	Moreover, phorbol myristate acetate enhanced Nedd4-2 phosphorylation and the formation of GLT-1 Nedd4-2 complexes, whereas siRNA knockdown of Nedd4-2 prevented ubiquitination, endocytosis, and the concomitant decrease in GLT-1 activity triggered by PKC activation.	Tetradecanoylphorbol Acetate	10-35	solute carrier family 1 member 2	Homo sapiens	90-95
22548401-3	2012	The release of VEGF-A by Human MCs-1 (HMC-1) was induced by calcium ionophore A23187 and phorbol 12 myristate 13 acetate (PMA).	Tetradecanoylphorbol Acetate	89-120	vascular endothelial growth factor A	Homo sapiens	15-21
22548401-3	2012	The release of VEGF-A by Human MCs-1 (HMC-1) was induced by calcium ionophore A23187 and phorbol 12 myristate 13 acetate (PMA).	Tetradecanoylphorbol Acetate	122-125	vascular endothelial growth factor A	Homo sapiens	15-21
22480848-4	2012	They also inhibited the PMA/lipopolysaccharide-induced proinflammatory cytokines, IL-1beta and TNF-alpha production in human monocytic leukemia cells (THP-1), by 86%, 46% and 59.2% for IL-1beta and by 83.8%, 48.2% and 58.7% for TNF-alpha, respectively.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 beta	Homo sapiens	82-90
22493297-3	2012	By gain-of-function and loss-of-function experiments, we demonstrated that both miRNAs promote the phorbol 12-myristate 13-acetate-induced monocytic and all-trans-retinoic acid-induced granulocytic differentiation of HL-60, THP-1, or NB4 cells.	Tetradecanoylphorbol Acetate	99-130	GLI family zinc finger 2	Homo sapiens	224-229
22590978-4	2012	Although basal or TPA induced phosphorylation of IkappaBalpha was not altered, its ubiquitination was markedly reduced in ORF2 expressing cells.	Tetradecanoylphorbol Acetate	18-21	NFKB inhibitor alpha	Homo sapiens	49-61
22503685-5	2012	In addition, PMA-induced phosphorylation of ERK1/2 and JNK were suppressed by JNP3 treatment, whereas the phosphorylation of p38 MAPK was not affected by JNP3.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 3	Homo sapiens	44-50
22503685-5	2012	In addition, PMA-induced phosphorylation of ERK1/2 and JNK were suppressed by JNP3 treatment, whereas the phosphorylation of p38 MAPK was not affected by JNP3.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 8	Homo sapiens	55-58
22480848-4	2012	They also inhibited the PMA/lipopolysaccharide-induced proinflammatory cytokines, IL-1beta and TNF-alpha production in human monocytic leukemia cells (THP-1), by 86%, 46% and 59.2% for IL-1beta and by 83.8%, 48.2% and 58.7% for TNF-alpha, respectively.	Tetradecanoylphorbol Acetate	24-27	tumor necrosis factor	Homo sapiens	95-104
22480848-4	2012	They also inhibited the PMA/lipopolysaccharide-induced proinflammatory cytokines, IL-1beta and TNF-alpha production in human monocytic leukemia cells (THP-1), by 86%, 46% and 59.2% for IL-1beta and by 83.8%, 48.2% and 58.7% for TNF-alpha, respectively.	Tetradecanoylphorbol Acetate	24-27	GLI family zinc finger 2	Homo sapiens	151-156
22480848-4	2012	They also inhibited the PMA/lipopolysaccharide-induced proinflammatory cytokines, IL-1beta and TNF-alpha production in human monocytic leukemia cells (THP-1), by 86%, 46% and 59.2% for IL-1beta and by 83.8%, 48.2% and 58.7% for TNF-alpha, respectively.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 beta	Homo sapiens	185-193
22480848-4	2012	They also inhibited the PMA/lipopolysaccharide-induced proinflammatory cytokines, IL-1beta and TNF-alpha production in human monocytic leukemia cells (THP-1), by 86%, 46% and 59.2% for IL-1beta and by 83.8%, 48.2% and 58.7% for TNF-alpha, respectively.	Tetradecanoylphorbol Acetate	24-27	tumor necrosis factor	Homo sapiens	228-237
22310390-6	2012	When cells were treated with p38 kinase inducer, hydrogen peroxide or phorbol 12-myristate 13-acetate (PMA), U6 promoter activity was down regulated and this inhibition was reversed by p38 kinase inhibitors.	Tetradecanoylphorbol Acetate	70-101	mitogen-activated protein kinase 14	Homo sapiens	29-32
22311708-1	2012	SOCS-3 gene induction by cAMP-elevating agents or the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), in primary HUVECs was found to require PKCeta- and PKCepsilon-dependent extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	88-119	mitogen-activated protein kinase 1	Homo sapiens	199-236
22311708-1	2012	SOCS-3 gene induction by cAMP-elevating agents or the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), in primary HUVECs was found to require PKCeta- and PKCepsilon-dependent extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	88-119	mitogen-activated protein kinase 1	Homo sapiens	238-241
22311708-1	2012	SOCS-3 gene induction by cAMP-elevating agents or the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), in primary HUVECs was found to require PKCeta- and PKCepsilon-dependent extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	121-124	mitogen-activated protein kinase 1	Homo sapiens	199-236
22311708-1	2012	SOCS-3 gene induction by cAMP-elevating agents or the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), in primary HUVECs was found to require PKCeta- and PKCepsilon-dependent extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	121-124	mitogen-activated protein kinase 1	Homo sapiens	238-241
22403260-4	2012	CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment.	Tetradecanoylphorbol Acetate	70-95	killer cell lectin like receptor B1	Homo sapiens	0-5
22403260-4	2012	CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment.	Tetradecanoylphorbol Acetate	70-95	C-X-C motif chemokine ligand 8	Homo sapiens	58-63
22403260-4	2012	CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment.	Tetradecanoylphorbol Acetate	97-100	killer cell lectin like receptor B1	Homo sapiens	0-5
22403260-4	2012	CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment.	Tetradecanoylphorbol Acetate	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	58-63
22403404-3	2012	Because the biologically active Vpr is found in serum and cerebrospinal fluid of HIV-infected patients, we investigated the apoptotic effect of Vpr on monocyte-derived macrophages and phorbol 12-myristate 13-acetate-activated THP1 macrophages.	Tetradecanoylphorbol Acetate	184-215	GLI family zinc finger 2	Homo sapiens	226-230
22313459-0	2012	TPA induces the expression of EC-SOD in human monocytic THP-1 cells: involvement of PKC, MEK/ERK and NOX-derived ROS.	Tetradecanoylphorbol Acetate	0-3	superoxide dismutase 3	Homo sapiens	30-36
22313459-0	2012	TPA induces the expression of EC-SOD in human monocytic THP-1 cells: involvement of PKC, MEK/ERK and NOX-derived ROS.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 7	Homo sapiens	89-92
22313459-0	2012	TPA induces the expression of EC-SOD in human monocytic THP-1 cells: involvement of PKC, MEK/ERK and NOX-derived ROS.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	93-96
22313459-4	2012	In this study, we investigated the expression of EC-SOD during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced monocytic differentiation of THP-1 cells, which is not expressing its gene in the basal phase.	Tetradecanoylphorbol Acetate	63-99	superoxide dismutase 3	Homo sapiens	49-55
22313459-4	2012	In this study, we investigated the expression of EC-SOD during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced monocytic differentiation of THP-1 cells, which is not expressing its gene in the basal phase.	Tetradecanoylphorbol Acetate	101-104	superoxide dismutase 3	Homo sapiens	49-55
22313459-5	2012	We confirmed the significant induction of EC-SOD in a TPA time-dependent manner, and that induction was completely blocked by pre-treatment with GF109203X, an inhibitor of protein kinase C, U0126 and PD98059, inhibitors of mitogen-activated protein kinase kinase/extracellular-signal regulated kinase.	Tetradecanoylphorbol Acetate	54-57	superoxide dismutase 3	Homo sapiens	42-48
22351750-3	2012	Proteoglycan extracts of [(35)S]sulfate- and (35)S-trans amino acid-radiolabeled culture media from THP-1 monocytes induced to differentiate by treatment with phorbol myristate acetate revealed three major proteins of ~25, 90, and 100 kDa following chondroitin ABC lyase digestion.	Tetradecanoylphorbol Acetate	159-184	GLI family zinc finger 2	Homo sapiens	100-105
22310390-6	2012	When cells were treated with p38 kinase inducer, hydrogen peroxide or phorbol 12-myristate 13-acetate (PMA), U6 promoter activity was down regulated and this inhibition was reversed by p38 kinase inhibitors.	Tetradecanoylphorbol Acetate	70-101	mitogen-activated protein kinase 14	Homo sapiens	185-188
22310390-6	2012	When cells were treated with p38 kinase inducer, hydrogen peroxide or phorbol 12-myristate 13-acetate (PMA), U6 promoter activity was down regulated and this inhibition was reversed by p38 kinase inhibitors.	Tetradecanoylphorbol Acetate	103-106	mitogen-activated protein kinase 14	Homo sapiens	29-32
22310390-6	2012	When cells were treated with p38 kinase inducer, hydrogen peroxide or phorbol 12-myristate 13-acetate (PMA), U6 promoter activity was down regulated and this inhibition was reversed by p38 kinase inhibitors.	Tetradecanoylphorbol Acetate	103-106	mitogen-activated protein kinase 14	Homo sapiens	185-188
22249152-4	2012	The kinetics of IL-4delta2 and IL-4 production by phorbol myristate acetate (PMA)/ionomycin-activated cells differed, with IL-4delta2 increasing at 48-72h and IL-4 peaking at 24h.	Tetradecanoylphorbol Acetate	50-75	interleukin 4	Homo sapiens	26-35
22297135-4	2012	Both vMIP-I and the vMIP-II gene products were detected 24 h post-induction with 12-O-tetradecanoylphorbol-13-acetate until 60 h in the cytoplasm of primary effusion lymphoma cell lines.	Tetradecanoylphorbol Acetate	81-117	K4	Human gammaherpesvirus 8	20-27
22389501-6	2012	Phorbol myristate acetate, a known stimulator of NF-kappaB, increased the levels of GRK5 in myocytes whereas treatment of cells with N-acetyl cysteine, a known inhibitor of NF-kappaB, or with SC 514, an inhibitor of IkappaB kinase 2 decreased GRK5.	Tetradecanoylphorbol Acetate	0-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-58
22389501-6	2012	Phorbol myristate acetate, a known stimulator of NF-kappaB, increased the levels of GRK5 in myocytes whereas treatment of cells with N-acetyl cysteine, a known inhibitor of NF-kappaB, or with SC 514, an inhibitor of IkappaB kinase 2 decreased GRK5.	Tetradecanoylphorbol Acetate	0-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	173-182
22268120-2	2012	Treatment of A549 lung epithelial cells or primary mouse tracheal surface epithelial (MTSE) cells with phorbol 12-myristate 13-acetate (PMA) increased the levels of tumor necrosis factor (TNF)-alpha in cell culture media compared with cells treated with vehicle alone.	Tetradecanoylphorbol Acetate	103-134	tumor necrosis factor	Mus musculus	165-198
22268120-2	2012	Treatment of A549 lung epithelial cells or primary mouse tracheal surface epithelial (MTSE) cells with phorbol 12-myristate 13-acetate (PMA) increased the levels of tumor necrosis factor (TNF)-alpha in cell culture media compared with cells treated with vehicle alone.	Tetradecanoylphorbol Acetate	136-139	tumor necrosis factor	Mus musculus	165-198
22249152-4	2012	The kinetics of IL-4delta2 and IL-4 production by phorbol myristate acetate (PMA)/ionomycin-activated cells differed, with IL-4delta2 increasing at 48-72h and IL-4 peaking at 24h.	Tetradecanoylphorbol Acetate	50-75	interleukin 4	Homo sapiens	16-20
22249152-4	2012	The kinetics of IL-4delta2 and IL-4 production by phorbol myristate acetate (PMA)/ionomycin-activated cells differed, with IL-4delta2 increasing at 48-72h and IL-4 peaking at 24h.	Tetradecanoylphorbol Acetate	77-80	interleukin 4	Homo sapiens	26-35
22249152-4	2012	The kinetics of IL-4delta2 and IL-4 production by phorbol myristate acetate (PMA)/ionomycin-activated cells differed, with IL-4delta2 increasing at 48-72h and IL-4 peaking at 24h.	Tetradecanoylphorbol Acetate	77-80	interleukin 4	Homo sapiens	16-20
21692984-11	2012	Addition of the PKC activator, phorbol 12-myristate 13-acetate and the specific PKC(epsilon) agonist, carbachol, blocked the effects of nicorandil on connexin43 phosphorylation and dye permeability.	Tetradecanoylphorbol Acetate	31-62	protein kinase C, epsilon	Rattus norvegicus	16-19
22178636-9	2012	alpha-MSH at physiologic doses potently suppressed basophil activation induced by N-formyl-methionyl-leucyl-phenylalanine, phorbol 12-myristate 13-acetate, or grass pollen allergen in whole blood of healthy or allergic subjects, respectively.	Tetradecanoylphorbol Acetate	123-154	proopiomelanocortin	Homo sapiens	0-9
22178636-11	2012	Moreover, alpha-MSH at physiologic doses significantly suppressed secretion of 3 proallergic cytokines, IL-4, IL-6, and IL-13, in basophils stimulated with anti-IgE, N-formyl-methionyl-leucyl-phenylalanine, or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	210-241	proopiomelanocortin	Homo sapiens	10-19
22151918-0	2012	Cucurbitacin B inhibits 12-O-tetradecanoylphorbol 13-acetate-induced invasion and migration of human hepatoma cells through inactivating mitogen-activated protein kinase and PI3K/Akt signal transduction pathways.	Tetradecanoylphorbol Acetate	24-60	AKT serine/threonine kinase 1	Homo sapiens	179-182
22151918-7	2012	RESULTS:   Cucurbitacin B has significantly suppressed 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cell invasion and migration in a concentration-dependent manner, which was accompanied with suppression of TPA-induced MMP-9 expression through inactivation of phosphorylation of extracellular signal-regulated kinase (ERK) 1/2, p38 and Akt.	Tetradecanoylphorbol Acetate	93-96	mitogen-activated protein kinase 3	Homo sapiens	285-332
22151918-7	2012	RESULTS:   Cucurbitacin B has significantly suppressed 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cell invasion and migration in a concentration-dependent manner, which was accompanied with suppression of TPA-induced MMP-9 expression through inactivation of phosphorylation of extracellular signal-regulated kinase (ERK) 1/2, p38 and Akt.	Tetradecanoylphorbol Acetate	93-96	mitogen-activated protein kinase 1	Homo sapiens	334-337
22151918-7	2012	RESULTS:   Cucurbitacin B has significantly suppressed 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cell invasion and migration in a concentration-dependent manner, which was accompanied with suppression of TPA-induced MMP-9 expression through inactivation of phosphorylation of extracellular signal-regulated kinase (ERK) 1/2, p38 and Akt.	Tetradecanoylphorbol Acetate	93-96	AKT serine/threonine kinase 1	Homo sapiens	342-345
22151918-8	2012	In the nucleus, it has also strongly suppressed TPA-stimulated expression of NF-kappaB, c-Jun and c-Fos.	Tetradecanoylphorbol Acetate	48-51	nuclear factor kappa B subunit 1	Homo sapiens	77-86
21692984-11	2012	Addition of the PKC activator, phorbol 12-myristate 13-acetate and the specific PKC(epsilon) agonist, carbachol, blocked the effects of nicorandil on connexin43 phosphorylation and dye permeability.	Tetradecanoylphorbol Acetate	31-62	gap junction protein, alpha 1	Rattus norvegicus	150-160
21480396-0	2012	Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase Cepsilon with Stat3 involve integration with ERK1/2.	Tetradecanoylphorbol Acetate	26-62	signal transducer and activator of transcription 3	Mus musculus	131-136
22411791-9	2012	These findings define the FOXO-PDGFRA axis as crucial mechanistic components that govern TPA-induced neuroblastoma differentiation.	Tetradecanoylphorbol Acetate	89-92	platelet derived growth factor receptor alpha	Homo sapiens	31-37
21480396-8	2012	Both UVR and TPA treatment stimulated PKCepsilon-Stat3 interaction, Stat3Ser727 phosphorylation and Stat3-regulated gene COX-2 expression.	Tetradecanoylphorbol Acetate	13-16	signal transducer and activator of transcription 3	Mus musculus	49-54
21480396-8	2012	Both UVR and TPA treatment stimulated PKCepsilon-Stat3 interaction, Stat3Ser727 phosphorylation and Stat3-regulated gene COX-2 expression.	Tetradecanoylphorbol Acetate	13-16	signal transducer and activator of transcription 3	Mus musculus	68-73
22337239-1	2012	OBJECTIVE: Previous reports have shown an increase in peripheral blood mononuclear cells" (PBMC) Th17 cell subpopulation and tumor necrosis factor-alpha (TNF-alpha) secretion after in vitro stimulation with anti-CD3/CD28 or phorbol myristate acetate/ionomycin in ankylosing spondylitis (AS).	Tetradecanoylphorbol Acetate	224-249	tumor necrosis factor	Homo sapiens	154-163
22230807-6	2012	In addition, the phorbol ester PMA alone or in combination with ionomycin induced a stronger increase in threonine phosphorylation of S100A9 in SLE than in Normal PBMCs, while the same stimuli caused the opposite effect on phosphorylation and activation of Erk1/2, suggesting the existence of an abnormal S100A9 signaling in SLE PBMCs.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 3	Homo sapiens	257-263
22125116-3	2012	Zymosan and/or PMA (Phorbol 12-myristate 13-acetate)-induced recruitment of p47(phox) and p67(phox) to the membrane fraction was normal for both mutants.	Tetradecanoylphorbol Acetate	15-18	CD33 molecule	Homo sapiens	90-93
22314224-6	2012	By transient transfection analysis with the MMP-1 promoter (-2846 to -29 nt) and AP-1 promoter, MMP-1 and AP-1 promoter activities were induced by phorbol myristate acetate (PMA) but were significantly inhibited by PD98059 (ERK1/2 inhibitor) or SP600125 (JNK inhibitor).	Tetradecanoylphorbol Acetate	147-172	mitogen-activated protein kinase 3	Homo sapiens	224-230
22314224-6	2012	By transient transfection analysis with the MMP-1 promoter (-2846 to -29 nt) and AP-1 promoter, MMP-1 and AP-1 promoter activities were induced by phorbol myristate acetate (PMA) but were significantly inhibited by PD98059 (ERK1/2 inhibitor) or SP600125 (JNK inhibitor).	Tetradecanoylphorbol Acetate	147-172	mitogen-activated protein kinase 8	Homo sapiens	255-258
22314224-6	2012	By transient transfection analysis with the MMP-1 promoter (-2846 to -29 nt) and AP-1 promoter, MMP-1 and AP-1 promoter activities were induced by phorbol myristate acetate (PMA) but were significantly inhibited by PD98059 (ERK1/2 inhibitor) or SP600125 (JNK inhibitor).	Tetradecanoylphorbol Acetate	174-177	mitogen-activated protein kinase 3	Homo sapiens	224-230
22199349-7	2012	At a functional level we show that PRMT5 inhibits the PKCdelta- or 12-O-tetradecanoylphorbol-13-acetate-dependent increase in human involucrin expression, and PRMT5 dimethylates proteins in the p38delta complex.	Tetradecanoylphorbol Acetate	67-103	protein arginine methyltransferase 5	Homo sapiens	35-40
21895511-8	2012	TNF-alpha treatment promoted NF-kappaB p65 binding to the M-CSF promoter in phorbol 12-myristate 13-acetate (PMA) treated U937 cells chronically infected with HIV-1 (U1 cells), but not in PMA treated uninfected U937 cells, suggesting that the presence of HIV-1 increases the NF-kappaB response.	Tetradecanoylphorbol Acetate	109-112	tumor necrosis factor	Homo sapiens	0-9
21895511-8	2012	TNF-alpha treatment promoted NF-kappaB p65 binding to the M-CSF promoter in phorbol 12-myristate 13-acetate (PMA) treated U937 cells chronically infected with HIV-1 (U1 cells), but not in PMA treated uninfected U937 cells, suggesting that the presence of HIV-1 increases the NF-kappaB response.	Tetradecanoylphorbol Acetate	109-112	nuclear factor kappa B subunit 1	Homo sapiens	29-38
21895511-8	2012	TNF-alpha treatment promoted NF-kappaB p65 binding to the M-CSF promoter in phorbol 12-myristate 13-acetate (PMA) treated U937 cells chronically infected with HIV-1 (U1 cells), but not in PMA treated uninfected U937 cells, suggesting that the presence of HIV-1 increases the NF-kappaB response.	Tetradecanoylphorbol Acetate	109-112	nuclear factor kappa B subunit 1	Homo sapiens	275-284
22314224-6	2012	By transient transfection analysis with the MMP-1 promoter (-2846 to -29 nt) and AP-1 promoter, MMP-1 and AP-1 promoter activities were induced by phorbol myristate acetate (PMA) but were significantly inhibited by PD98059 (ERK1/2 inhibitor) or SP600125 (JNK inhibitor).	Tetradecanoylphorbol Acetate	174-177	mitogen-activated protein kinase 8	Homo sapiens	255-258
22349513-3	2012	KLF10 deficient mice exhibited increased predisposition to skin tumorigenesis and markedly accelerated papilloma development after DMBA/TPA treatment.	Tetradecanoylphorbol Acetate	136-139	Kruppel-like factor 10	Mus musculus	0-5
21895511-8	2012	TNF-alpha treatment promoted NF-kappaB p65 binding to the M-CSF promoter in phorbol 12-myristate 13-acetate (PMA) treated U937 cells chronically infected with HIV-1 (U1 cells), but not in PMA treated uninfected U937 cells, suggesting that the presence of HIV-1 increases the NF-kappaB response.	Tetradecanoylphorbol Acetate	76-107	tumor necrosis factor	Homo sapiens	0-9
21895511-8	2012	TNF-alpha treatment promoted NF-kappaB p65 binding to the M-CSF promoter in phorbol 12-myristate 13-acetate (PMA) treated U937 cells chronically infected with HIV-1 (U1 cells), but not in PMA treated uninfected U937 cells, suggesting that the presence of HIV-1 increases the NF-kappaB response.	Tetradecanoylphorbol Acetate	76-107	nuclear factor kappa B subunit 1	Homo sapiens	29-38
21895511-8	2012	TNF-alpha treatment promoted NF-kappaB p65 binding to the M-CSF promoter in phorbol 12-myristate 13-acetate (PMA) treated U937 cells chronically infected with HIV-1 (U1 cells), but not in PMA treated uninfected U937 cells, suggesting that the presence of HIV-1 increases the NF-kappaB response.	Tetradecanoylphorbol Acetate	76-107	nuclear factor kappa B subunit 1	Homo sapiens	275-284
22300615-8	2012	Thrombin effects were mimicked by phorbol 12-myristate 13-acetate (PMA), further confirming the involvement of diacylglycerol (DAG)-sensitive classical and novel PKC isoforms in thrombin-induced actin cytoskeleton modification.	Tetradecanoylphorbol Acetate	34-65	coagulation factor II	Rattus norvegicus	0-8
22300615-8	2012	Thrombin effects were mimicked by phorbol 12-myristate 13-acetate (PMA), further confirming the involvement of diacylglycerol (DAG)-sensitive classical and novel PKC isoforms in thrombin-induced actin cytoskeleton modification.	Tetradecanoylphorbol Acetate	34-65	coagulation factor II	Rattus norvegicus	178-186
22300615-8	2012	Thrombin effects were mimicked by phorbol 12-myristate 13-acetate (PMA), further confirming the involvement of diacylglycerol (DAG)-sensitive classical and novel PKC isoforms in thrombin-induced actin cytoskeleton modification.	Tetradecanoylphorbol Acetate	67-70	coagulation factor II	Rattus norvegicus	0-8
22300615-8	2012	Thrombin effects were mimicked by phorbol 12-myristate 13-acetate (PMA), further confirming the involvement of diacylglycerol (DAG)-sensitive classical and novel PKC isoforms in thrombin-induced actin cytoskeleton modification.	Tetradecanoylphorbol Acetate	67-70	coagulation factor II	Rattus norvegicus	178-186
22125116-3	2012	Zymosan and/or PMA (Phorbol 12-myristate 13-acetate)-induced recruitment of p47(phox) and p67(phox) to the membrane fraction was normal for both mutants.	Tetradecanoylphorbol Acetate	20-51	CD33 molecule	Homo sapiens	90-93
22181070-6	2012	In addition, phloretin inhibited the phosphorylation as well as the catalytic activity of extracellular signal-regulated kinase (ERK), which was previously found to activate NF-kappaB and induce COX-2 expression in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	215-218	mitogen-activated protein kinase 1	Mus musculus	90-127
22179411-7	2012	Interestingly, additional cell culture experiments showed the             ability of BAI to repress the PMA-induced COX-2 expression in A549 cells and serum-dependent             COX-2 expression in NCI-H292 cells, a human laryngeal cell line.	Tetradecanoylphorbol Acetate	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
22181070-6	2012	In addition, phloretin inhibited the phosphorylation as well as the catalytic activity of extracellular signal-regulated kinase (ERK), which was previously found to activate NF-kappaB and induce COX-2 expression in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	215-218	mitogen-activated protein kinase 1	Mus musculus	129-132
22181070-7	2012	Taken together, the inhibitory effects of phloretin on TPA-induced NF-kappaB activation and COX-2 expression through the modulation of ERK signaling may partly account for its antitumor-promoting effect on mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 1	Mus musculus	135-138
22200849-6	2012	In addition, Jurkat T cells, transfected with various expression plasmids and/or stimulated with TPA, UV or ionomycin strongly induced the c-Jun N-terminal kinase (JNK) and p38, whereas the extracellular signal-regulated kinase (ERK)-1/2 kinase pathway was weekly activated.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 3	Homo sapiens	190-237
22340895-6	2012	RESULTS: Both (-) and (+)-naloxone equally inhibited LPS- and PMA-induced superoxide production with an IC50 of 1.96 and 2.52 muM, respectively.	Tetradecanoylphorbol Acetate	62-65	latexin	Homo sapiens	126-129
22200849-6	2012	In addition, Jurkat T cells, transfected with various expression plasmids and/or stimulated with TPA, UV or ionomycin strongly induced the c-Jun N-terminal kinase (JNK) and p38, whereas the extracellular signal-regulated kinase (ERK)-1/2 kinase pathway was weekly activated.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 8	Homo sapiens	139-162
22200849-6	2012	In addition, Jurkat T cells, transfected with various expression plasmids and/or stimulated with TPA, UV or ionomycin strongly induced the c-Jun N-terminal kinase (JNK) and p38, whereas the extracellular signal-regulated kinase (ERK)-1/2 kinase pathway was weekly activated.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 8	Homo sapiens	164-167
22200849-6	2012	In addition, Jurkat T cells, transfected with various expression plasmids and/or stimulated with TPA, UV or ionomycin strongly induced the c-Jun N-terminal kinase (JNK) and p38, whereas the extracellular signal-regulated kinase (ERK)-1/2 kinase pathway was weekly activated.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 1	Homo sapiens	173-176
22336225-4	2012	Other indicators of PMA-induced HEL cell differentiation, such as increased expression of CD41/CD61 and an increase in cell complexity/granularity, were inhibited by cicaprost in an IP receptor-dependent and STAT3-dependent manner.	Tetradecanoylphorbol Acetate	20-23	integrin subunit beta 3	Homo sapiens	95-99
22336225-4	2012	Other indicators of PMA-induced HEL cell differentiation, such as increased expression of CD41/CD61 and an increase in cell complexity/granularity, were inhibited by cicaprost in an IP receptor-dependent and STAT3-dependent manner.	Tetradecanoylphorbol Acetate	20-23	signal transducer and activator of transcription 3	Homo sapiens	208-213
22052014-5	2012	We show that, in response to PMA, PKCdelta, a member of novel PKC isozymes, and MEK-ERK1/2 pathway of mitogen-activated protein kinases stimulate the NHE2 expression in C2BBe1 intestinal epithelial cells.	Tetradecanoylphorbol Acetate	29-32	mitogen-activated protein kinase kinase 7	Homo sapiens	80-83
22052014-8	2012	In addition, blockade of PKCdelta by rottlerin, a PKCdelta-specific inhibitor, and ERK1/2 by U0126, a MEK-ERK inhibitor, abrogated PMA-induced Egr-1 expression.	Tetradecanoylphorbol Acetate	131-134	mitogen-activated protein kinase 3	Homo sapiens	83-89
21718304-3	2012	KEY RESULTS: Orexin stimulation strongly increased PLD activity - even more so than the phorbol ester TPA (12-O-tetradecanoyl-phorbol-13-acetate), a highly potent activator of PLD.	Tetradecanoylphorbol Acetate	107-144	phospholipase D1	Cricetulus griseus	176-179
22052014-8	2012	In addition, blockade of PKCdelta by rottlerin, a PKCdelta-specific inhibitor, and ERK1/2 by U0126, a MEK-ERK inhibitor, abrogated PMA-induced Egr-1 expression.	Tetradecanoylphorbol Acetate	131-134	mitogen-activated protein kinase kinase 7	Homo sapiens	102-105
22052014-8	2012	In addition, blockade of PKCdelta by rottlerin, a PKCdelta-specific inhibitor, and ERK1/2 by U0126, a MEK-ERK inhibitor, abrogated PMA-induced Egr-1 expression.	Tetradecanoylphorbol Acetate	131-134	mitogen-activated protein kinase 1	Homo sapiens	83-86
21923556-5	2012	Treatment with phorbol 12-myristate 13-acetate (PMA) for 30 min (short-term) activated Erk1/2, whereas 12 h (long-term) PMA treatment abrogated PKCalpha, reduced Erk1/2 activation and significantly increased cell death under OGD.	Tetradecanoylphorbol Acetate	15-46	mitogen-activated protein kinase 3	Homo sapiens	87-93
21923556-5	2012	Treatment with phorbol 12-myristate 13-acetate (PMA) for 30 min (short-term) activated Erk1/2, whereas 12 h (long-term) PMA treatment abrogated PKCalpha, reduced Erk1/2 activation and significantly increased cell death under OGD.	Tetradecanoylphorbol Acetate	15-46	mitogen-activated protein kinase 3	Homo sapiens	162-168
21923556-5	2012	Treatment with phorbol 12-myristate 13-acetate (PMA) for 30 min (short-term) activated Erk1/2, whereas 12 h (long-term) PMA treatment abrogated PKCalpha, reduced Erk1/2 activation and significantly increased cell death under OGD.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 3	Homo sapiens	87-93
21923556-5	2012	Treatment with phorbol 12-myristate 13-acetate (PMA) for 30 min (short-term) activated Erk1/2, whereas 12 h (long-term) PMA treatment abrogated PKCalpha, reduced Erk1/2 activation and significantly increased cell death under OGD.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 3	Homo sapiens	162-168
21923556-5	2012	Treatment with phorbol 12-myristate 13-acetate (PMA) for 30 min (short-term) activated Erk1/2, whereas 12 h (long-term) PMA treatment abrogated PKCalpha, reduced Erk1/2 activation and significantly increased cell death under OGD.	Tetradecanoylphorbol Acetate	120-123	protein kinase C alpha	Homo sapiens	144-152
21923556-5	2012	Treatment with phorbol 12-myristate 13-acetate (PMA) for 30 min (short-term) activated Erk1/2, whereas 12 h (long-term) PMA treatment abrogated PKCalpha, reduced Erk1/2 activation and significantly increased cell death under OGD.	Tetradecanoylphorbol Acetate	120-123	mitogen-activated protein kinase 3	Homo sapiens	162-168
21718304-4	2012	Both orexin and TPA responses were mediated by PLD1.	Tetradecanoylphorbol Acetate	16-19	phospholipase D1	Cricetulus griseus	47-51
21718304-6	2012	Using pharmacological inhibitors and activators, both orexin and TPA were shown to signal to PLD1 via the novel PKC isoform, PKCdelta.	Tetradecanoylphorbol Acetate	65-68	phospholipase D1	Cricetulus griseus	93-97
22020547-11	2012	Taken together, we             suggest that TPA reciprocally regulates the level of p21 and p53 expression via             a MEK/ERK-dependent pathway.	Tetradecanoylphorbol Acetate	44-47	tumor protein p53	Homo sapiens	92-95
22036979-0	2012	Caffeic acid attenuates 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced NF-kappaB and COX-2 expression in mouse skin: abrogation of oxidative stress, inflammatory responses and proinflammatory cytokine production.	Tetradecanoylphorbol Acetate	24-61	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-85
22036979-0	2012	Caffeic acid attenuates 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced NF-kappaB and COX-2 expression in mouse skin: abrogation of oxidative stress, inflammatory responses and proinflammatory cytokine production.	Tetradecanoylphorbol Acetate	63-66	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-85
22036979-6	2012	Further, CA was found to inhibit the TPA induced expression of NF-kappaB and COX-2.	Tetradecanoylphorbol Acetate	37-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-72
22036979-7	2012	Thus, our results suggest that CA attenuates TPA induced tumor promotional triggers possibly by inhibition of oxidative and inflammatory responses thereby diminishing the expression of NF-kappaB and COX-2.	Tetradecanoylphorbol Acetate	45-48	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	185-194
22108199-3	2012	Here, we used a strategy of overexpression and inhibition of miR-BHRF1-1 and showed that miR-BHRF1-1 is involved in TPA-induced accumulation of EBV lytic proteins and viral copies in late lytic cycle.	Tetradecanoylphorbol Acetate	116-119	apoptosis regulator BHRF1	Human gammaherpesvirus 4	65-72
22108199-3	2012	Here, we used a strategy of overexpression and inhibition of miR-BHRF1-1 and showed that miR-BHRF1-1 is involved in TPA-induced accumulation of EBV lytic proteins and viral copies in late lytic cycle.	Tetradecanoylphorbol Acetate	116-119	apoptosis regulator BHRF1	Human gammaherpesvirus 4	93-100
22370345-5	2012	In NCM460 cells exposed to PMA (an ERK1/2 activator), the phosphorylation of ERK1/2 did not affect the interaction between toxin A and ERK1/2.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 3	Homo sapiens	35-41
22370345-5	2012	In NCM460 cells exposed to PMA (an ERK1/2 activator), the phosphorylation of ERK1/2 did not affect the interaction between toxin A and ERK1/2.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 3	Homo sapiens	77-83
22370345-5	2012	In NCM460 cells exposed to PMA (an ERK1/2 activator), the phosphorylation of ERK1/2 did not affect the interaction between toxin A and ERK1/2.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 3	Homo sapiens	77-83
22020547-0	2012	TPA-induced p21 expression augments G2/M arrest through a p53-independent             mechanism in human breast cancer cells.	Tetradecanoylphorbol Acetate	0-3	tumor protein p53	Homo sapiens	58-61
22020547-4	2012	Our results showed that TPA increased the level of p21 expression             in MCF-7 cells with wild-type p53 and MDA-MB-231 cells with mutant p53 in a dose-dependent             manner.	Tetradecanoylphorbol Acetate	24-27	tumor protein p53	Homo sapiens	108-111
22020547-4	2012	Our results showed that TPA increased the level of p21 expression             in MCF-7 cells with wild-type p53 and MDA-MB-231 cells with mutant p53 in a dose-dependent             manner.	Tetradecanoylphorbol Acetate	24-27	tumor protein p53	Homo sapiens	145-148
22020547-5	2012	In contrast, TPA decreased the expression of p53 in MCF-7 cells, but did             not affect MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	13-16	tumor protein p53	Homo sapiens	45-48
22020547-11	2012	Taken together, we             suggest that TPA reciprocally regulates the level of p21 and p53 expression via             a MEK/ERK-dependent pathway.	Tetradecanoylphorbol Acetate	44-47	mitogen-activated protein kinase kinase 7	Homo sapiens	125-128
22020547-6	2012	We next examined the regulatory mechanism of TPA             on p21 and p53 expression.	Tetradecanoylphorbol Acetate	45-48	tumor protein p53	Homo sapiens	72-75
22020547-7	2012	Our results showed that the TPA-induced up-regulation             of p21 and down-regulation of p53 was reversed by UO126 (a MEK1/2 inhibitor),             but not by SP600125 (a JNK inhibitor) or SB203580 (a p38 inhibitor), although             TPA increased the phosphorylation of ERK and JNK in MCF-7 cells.	Tetradecanoylphorbol Acetate	28-31	tumor protein p53	Homo sapiens	96-99
22020547-11	2012	Taken together, we             suggest that TPA reciprocally regulates the level of p21 and p53 expression via             a MEK/ERK-dependent pathway.	Tetradecanoylphorbol Acetate	44-47	mitogen-activated protein kinase 1	Homo sapiens	129-132
22020547-7	2012	Our results showed that the TPA-induced up-regulation             of p21 and down-regulation of p53 was reversed by UO126 (a MEK1/2 inhibitor),             but not by SP600125 (a JNK inhibitor) or SB203580 (a p38 inhibitor), although             TPA increased the phosphorylation of ERK and JNK in MCF-7 cells.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 8	Homo sapiens	179-182
22020547-7	2012	Our results showed that the TPA-induced up-regulation             of p21 and down-regulation of p53 was reversed by UO126 (a MEK1/2 inhibitor),             but not by SP600125 (a JNK inhibitor) or SB203580 (a p38 inhibitor), although             TPA increased the phosphorylation of ERK and JNK in MCF-7 cells.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 14	Homo sapiens	209-212
22020547-12	2012	The up-regulation of p21 in response to TPA is mediated             through a p53-independent mechanism in breast cancer cells.	Tetradecanoylphorbol Acetate	40-43	tumor protein p53	Homo sapiens	78-81
22020547-7	2012	Our results showed that the TPA-induced up-regulation             of p21 and down-regulation of p53 was reversed by UO126 (a MEK1/2 inhibitor),             but not by SP600125 (a JNK inhibitor) or SB203580 (a p38 inhibitor), although             TPA increased the phosphorylation of ERK and JNK in MCF-7 cells.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 1	Homo sapiens	283-286
22020547-7	2012	Our results showed that the TPA-induced up-regulation             of p21 and down-regulation of p53 was reversed by UO126 (a MEK1/2 inhibitor),             but not by SP600125 (a JNK inhibitor) or SB203580 (a p38 inhibitor), although             TPA increased the phosphorylation of ERK and JNK in MCF-7 cells.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 8	Homo sapiens	291-294
22004728-5	2012	Our results show that phorbol 12-myristate 13-acetate (PMA) treatment increases ARF4 expression at both the transcriptional and translational levels.	Tetradecanoylphorbol Acetate	22-53	ADP ribosylation factor 4	Homo sapiens	80-84
22081309-5	2012	Phorbol 12-myristate 13-acetate-activated granulocytes (CD16(low)/CD66b(++)/CD15(+)) that have a phenotype similar to MDSCs from cancer patients, effectively suppressed both proliferation and cytotoxicity of normal T cells.	Tetradecanoylphorbol Acetate	0-31	CEA cell adhesion molecule 8	Homo sapiens	66-71
22081309-5	2012	Phorbol 12-myristate 13-acetate-activated granulocytes (CD16(low)/CD66b(++)/CD15(+)) that have a phenotype similar to MDSCs from cancer patients, effectively suppressed both proliferation and cytotoxicity of normal T cells.	Tetradecanoylphorbol Acetate	0-31	fucosyltransferase 4	Homo sapiens	76-80
22206674-0	2012	PMA induces GCMa phosphorylation and alters its stability via the PKC- and ERK-dependent pathway.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	75-78
22004728-5	2012	Our results show that phorbol 12-myristate 13-acetate (PMA) treatment increases ARF4 expression at both the transcriptional and translational levels.	Tetradecanoylphorbol Acetate	55-58	ADP ribosylation factor 4	Homo sapiens	80-84
21949158-9	2012	Together, these results suggest that PKC is likely to be involved in LL absorption, and the ability of PMA/ionomycin to block the terbutaline-induced increase in J(v) suggests that the downstream target of PKC is ENaC.	Tetradecanoylphorbol Acetate	103-106	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	213-217
20454814-4	2012	Overexpression of MnSOD in transgenic mice reduces the incidences and multiplicity of papillomas in a DMBA/TPA skin carcinogenesis model.	Tetradecanoylphorbol Acetate	107-110	superoxide dismutase 2, mitochondrial	Mus musculus	18-23
22938493-0	2012	Phorbol ester TPA modulates chemoresistance in the drug sensitive breast cancer cell line MCF-7 by inducing expression of drug efflux transporter ABCG2.	Tetradecanoylphorbol Acetate	14-17	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	146-151
22901184-0	2012	PBK/TOPK expression during TPA-induced HL-60 leukemic cell differentiation.	Tetradecanoylphorbol Acetate	27-30	PDZ binding kinase	Homo sapiens	0-3
22901184-0	2012	PBK/TOPK expression during TPA-induced HL-60 leukemic cell differentiation.	Tetradecanoylphorbol Acetate	27-30	PDZ binding kinase	Homo sapiens	4-8
22988493-5	2012	In contrast to this observation, but in keeping with literature, PKC activation by phorbol-12-myristate-13-acetate (PMA) also led to the expression of senescence markers.	Tetradecanoylphorbol Acetate	83-114	protein kinase C alpha	Homo sapiens	65-68
22988493-5	2012	In contrast to this observation, but in keeping with literature, PKC activation by phorbol-12-myristate-13-acetate (PMA) also led to the expression of senescence markers.	Tetradecanoylphorbol Acetate	116-119	protein kinase C alpha	Homo sapiens	65-68
22988493-6	2012	We explain this antithesis by demonstrating that PMA-treated cells show reduction in the activity of PKC alpha, thereby simulating inhibition.	Tetradecanoylphorbol Acetate	49-52	protein kinase C alpha	Homo sapiens	101-110
22901184-1	2012	OBJECTIVE: This study concerns expression of PBK/TOPK during differentiation of HL-60 leukemic cells induced by tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	112-141	PDZ binding kinase	Homo sapiens	45-48
22901184-1	2012	OBJECTIVE: This study concerns expression of PBK/TOPK during differentiation of HL-60 leukemic cells induced by tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	112-141	PDZ binding kinase	Homo sapiens	49-53
22938493-3	2012	In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression using the COX-2 inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) in human breast cancer cell lines.	Tetradecanoylphorbol Acetate	125-161	prostaglandin-endoperoxide synthase 2	Homo sapiens	69-74
22901184-1	2012	OBJECTIVE: This study concerns expression of PBK/TOPK during differentiation of HL-60 leukemic cells induced by tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	143-146	PDZ binding kinase	Homo sapiens	45-48
22901184-1	2012	OBJECTIVE: This study concerns expression of PBK/TOPK during differentiation of HL-60 leukemic cells induced by tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	143-146	PDZ binding kinase	Homo sapiens	49-53
22938493-3	2012	In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression using the COX-2 inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) in human breast cancer cell lines.	Tetradecanoylphorbol Acetate	125-161	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	79-84
22938493-3	2012	In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression using the COX-2 inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) in human breast cancer cell lines.	Tetradecanoylphorbol Acetate	125-161	prostaglandin-endoperoxide synthase 2	Homo sapiens	111-116
22938493-3	2012	In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression using the COX-2 inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) in human breast cancer cell lines.	Tetradecanoylphorbol Acetate	163-166	prostaglandin-endoperoxide synthase 2	Homo sapiens	69-74
22938493-3	2012	In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression using the COX-2 inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) in human breast cancer cell lines.	Tetradecanoylphorbol Acetate	163-166	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	79-84
22938493-3	2012	In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression using the COX-2 inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) in human breast cancer cell lines.	Tetradecanoylphorbol Acetate	163-166	prostaglandin-endoperoxide synthase 2	Homo sapiens	111-116
22938493-5	2012	A significant increase of COX-2 mRNA expression (up to 11-fold by 4 h) was induced by TPA in MDA-MB-231 cells, this induction effect being lower in MCF-7 cells.	Tetradecanoylphorbol Acetate	86-89	prostaglandin-endoperoxide synthase 2	Homo sapiens	26-31
22938493-6	2012	TPA caused a considerable increase up to 9-fold in ABCG2 mRNA expression in parental MCF-7 cells, while it caused a small enhancement in ABCG2 expression up to 67 % by 4 h followed by a time-dependent decrease in ABCG2 mRNA expression in MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	0-3	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	51-56
22938493-6	2012	TPA caused a considerable increase up to 9-fold in ABCG2 mRNA expression in parental MCF-7 cells, while it caused a small enhancement in ABCG2 expression up to 67 % by 4 h followed by a time-dependent decrease in ABCG2 mRNA expression in MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	0-3	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	137-142
22938493-6	2012	TPA caused a considerable increase up to 9-fold in ABCG2 mRNA expression in parental MCF-7 cells, while it caused a small enhancement in ABCG2 expression up to 67 % by 4 h followed by a time-dependent decrease in ABCG2 mRNA expression in MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	0-3	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	137-142
22938493-7	2012	TPA treatment resulted in a slight increase of ABCG2 protein expression in MCF-7 cells, while a time-dependent decrease in ABCG2 protein expression was occurred in MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	0-3	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	47-52
22938493-8	2012	In conclusion, based on the observed effects of TPA in MDA-Mb-231 cells, it is proposed that TPA up-regulates ABCG2 expression in the drug sensitive MCF-7 breast cancer cell line through COX-2 unrelated pathways.	Tetradecanoylphorbol Acetate	93-96	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	110-115
22938493-8	2012	In conclusion, based on the observed effects of TPA in MDA-Mb-231 cells, it is proposed that TPA up-regulates ABCG2 expression in the drug sensitive MCF-7 breast cancer cell line through COX-2 unrelated pathways.	Tetradecanoylphorbol Acetate	93-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	187-192
22382313-6	2012	KPS-A treatment suppressed PMA-induced phosphorylation of extracellular signal regulated kinase (ERK)1/2 and Akt.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 3	Homo sapiens	58-104
22382313-6	2012	KPS-A treatment suppressed PMA-induced phosphorylation of extracellular signal regulated kinase (ERK)1/2 and Akt.	Tetradecanoylphorbol Acetate	27-30	AKT serine/threonine kinase 1	Homo sapiens	109-112
22523472-7	2012	HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-kappaB.	Tetradecanoylphorbol Acetate	57-88	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
22975632-3	2012	We previously observed that phorbol 12-myristate 13-acetate (PMA) stimulates phosphorylation of GCMa on serines 328, 378 and 383 through the protein kinase C (PKC)- and mitogen-activated protein kinase kinase (MEK)/extracellular signalregulated kinase (ERK)-dependent pathway, which decreases the protein stability of GCMa.	Tetradecanoylphorbol Acetate	28-59	rolled	Drosophila melanogaster	253-256
22975632-3	2012	We previously observed that phorbol 12-myristate 13-acetate (PMA) stimulates phosphorylation of GCMa on serines 328, 378 and 383 through the protein kinase C (PKC)- and mitogen-activated protein kinase kinase (MEK)/extracellular signalregulated kinase (ERK)-dependent pathway, which decreases the protein stability of GCMa.	Tetradecanoylphorbol Acetate	61-64	rolled	Drosophila melanogaster	253-256
22523472-7	2012	HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-kappaB.	Tetradecanoylphorbol Acetate	57-88	nuclear factor kappa B subunit 1	Homo sapiens	151-160
22523472-7	2012	HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-kappaB.	Tetradecanoylphorbol Acetate	90-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	137-142
22523472-7	2012	HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-kappaB.	Tetradecanoylphorbol Acetate	90-93	nuclear factor kappa B subunit 1	Homo sapiens	151-160
22523472-8	2012	We found that resveratrol efficiently reversed the PMA-induced MMP-9 secretion and COX-2 expression.	Tetradecanoylphorbol Acetate	51-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
22685674-3	2012	We have found that TPA-induced differentiation of ML-1 cells was accompanied by the upregulation of TLR1, TLR2, TLR4, and CD14 expression at both the mRNA and protein levels.	Tetradecanoylphorbol Acetate	19-22	toll like receptor 1	Homo sapiens	100-104
22893789-6	2012	The current study now identifies Wnt5a signaling as a new target of TAM67 when it inhibits DMBA/TPA-induced carcinogenesis.	Tetradecanoylphorbol Acetate	96-99	Wnt family member 5A	Homo sapiens	33-38
22414682-5	2012	RESULTS: The levels of IL-8 and GRO-alpha were significantly increased after treatment with EGF, TGF-alpha, TNF-alpha and TPA by primary cultured granulosa-lutein cells.	Tetradecanoylphorbol Acetate	122-125	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
22773962-4	2012	We showed that short-term activation of PKC by phobol 12-Myristate 13-Acetate (PMA) inhibited hOAT3 activity through accelerating its internalization from cell surface to intracellular recycling endosomes.	Tetradecanoylphorbol Acetate	79-82	proline rich transmembrane protein 2	Homo sapiens	40-43
22685674-3	2012	We have found that TPA-induced differentiation of ML-1 cells was accompanied by the upregulation of TLR1, TLR2, TLR4, and CD14 expression at both the mRNA and protein levels.	Tetradecanoylphorbol Acetate	19-22	toll like receptor 2	Homo sapiens	106-110
22685674-5	2012	In addition, the expression of IRAK-2, a key member of the TLR/IRAK-2/NF-kappaB-dependent signaling cascade was also induced in response to TPA.	Tetradecanoylphorbol Acetate	140-143	interleukin 1 receptor associated kinase 2	Homo sapiens	31-37
22685674-5	2012	In addition, the expression of IRAK-2, a key member of the TLR/IRAK-2/NF-kappaB-dependent signaling cascade was also induced in response to TPA.	Tetradecanoylphorbol Acetate	140-143	interleukin 1 receptor associated kinase 2	Homo sapiens	63-69
22685674-5	2012	In addition, the expression of IRAK-2, a key member of the TLR/IRAK-2/NF-kappaB-dependent signaling cascade was also induced in response to TPA.	Tetradecanoylphorbol Acetate	140-143	nuclear factor kappa B subunit 1	Homo sapiens	70-79
22685674-8	2012	Together, these data suggest that the increase in the responsiveness of TPA-treated ML-1 cells to LPS and LTA occurs in response to the upregulation of their respective receptors as well as an induction of the IRAK-2 gene expression.	Tetradecanoylphorbol Acetate	72-75	interleukin 1 receptor associated kinase 2	Homo sapiens	210-216
22293298-8	2012	Moreover, CR4-1 attenuated TPA-induced degradation of kappaBalpha inhibitor (IkappaB-alpha).	Tetradecanoylphorbol Acetate	27-30	NFKB inhibitor alpha	Homo sapiens	54-90
22675249-3	2012	We used phorbol 12-myristate 13-acetate- (PMA-) differentiated THP-1 cells as the in vitro model of monocyte/macrophage cells to study the signaling pathways involved in IL-4-regulated expression of DC-SIGN.	Tetradecanoylphorbol Acetate	8-39	CD209 molecule	Homo sapiens	199-206
22416475-5	2012	Th1/Th2 and Tc1/Tc2 were determined by analyzing intracellular cytokine staining for IFN-gamma and IL-4 in blood CD4+ and CD8+ T cells using flow cytometry after stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	179-182	interleukin 4	Homo sapiens	99-103
22690041-6	2012	The percentage of CD4(+) cells producing interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in response to PMA/ionomycin was significantly reduced in pregnancy.	Tetradecanoylphorbol Acetate	129-132	interferon gamma	Homo sapiens	41-68
22690041-6	2012	The percentage of CD4(+) cells producing interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in response to PMA/ionomycin was significantly reduced in pregnancy.	Tetradecanoylphorbol Acetate	129-132	tumor necrosis factor	Homo sapiens	74-101
22690041-6	2012	The percentage of CD4(+) cells producing interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in response to PMA/ionomycin was significantly reduced in pregnancy.	Tetradecanoylphorbol Acetate	129-132	CD4 molecule	Homo sapiens	18-21
22690041-6	2012	The percentage of CD4(+) cells producing interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in response to PMA/ionomycin was significantly reduced in pregnancy.	Tetradecanoylphorbol Acetate	129-132	tumor necrosis factor	Homo sapiens	103-112
22629859-3	2012	Caspase-3 and TsPO expression was measured in squamous cell carcinoma cells after incubation with phorbol-12-myristate 13-acetate and ultraviolet radiation.	Tetradecanoylphorbol Acetate	98-129	caspase 3	Homo sapiens	0-9
21984036-11	2012	Heparin can decrease the level of Duox1, ROS production and block the PMA-induced activation of EGFR, thus inhibiting the overexpression of mucin MUC5AC in a dose-dependent manner.	Tetradecanoylphorbol Acetate	70-73	epidermal growth factor receptor	Homo sapiens	96-100
22273510-13	2012	In contrast, by the addition of tPA, both fibrinogen and FXIII separately and, to more extent, in combination enhanced clot quality as well as resistance against tPA-induced fibrinolysis (increasing MCF, AUC, and lysis onset time).	Tetradecanoylphorbol Acetate	32-35	fibrinogen beta chain	Homo sapiens	42-52
22273510-13	2012	In contrast, by the addition of tPA, both fibrinogen and FXIII separately and, to more extent, in combination enhanced clot quality as well as resistance against tPA-induced fibrinolysis (increasing MCF, AUC, and lysis onset time).	Tetradecanoylphorbol Acetate	162-165	fibrinogen beta chain	Homo sapiens	42-52
23300800-8	2012	Moreover, butyrate enhanced the PMA-induced expression of c-fos and ERK1/2 phosphorylation, but not p38 and JNK.	Tetradecanoylphorbol Acetate	32-35	mitogen-activated protein kinase 3	Homo sapiens	68-74
22509363-5	2012	While the stem cell compartment appears unaffected, interfollicular keratinocytes lacking functional Miz1 exhibit a reduced proliferation and an accelerated differentiation of the epidermis in response to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	262-265	zinc finger and BTB domain containing 17	Homo sapiens	101-105
23056468-9	2012	In addition, ING4 suppressed PMA-induced cell invasion and NF-kappaB-target gene expression in T47D cells, indicating that ING4 inhibited NF-kappaB activity in breast cancer cells.	Tetradecanoylphorbol Acetate	29-32	nuclear factor kappa B subunit 1	Homo sapiens	138-147
22911849-9	2012	Over-expression of the dominant negative p53 mutant DeltaTAp53, which inhibits p53 activity, prevented the TPA-induced K14 down-regulation in C9 cells.	Tetradecanoylphorbol Acetate	107-110	tumor protein p53	Homo sapiens	41-44
22911849-9	2012	Over-expression of the dominant negative p53 mutant DeltaTAp53, which inhibits p53 activity, prevented the TPA-induced K14 down-regulation in C9 cells.	Tetradecanoylphorbol Acetate	107-110	tumor protein p53	Homo sapiens	59-62
22911849-11	2012	Finally, we found that TPA induces the phosphorylation of p53 at residue 378, which enhances the affinity of p53 to bind to Sp1 and repress K14 expression.	Tetradecanoylphorbol Acetate	23-26	tumor protein p53	Homo sapiens	58-61
22911849-11	2012	Finally, we found that TPA induces the phosphorylation of p53 at residue 378, which enhances the affinity of p53 to bind to Sp1 and repress K14 expression.	Tetradecanoylphorbol Acetate	23-26	tumor protein p53	Homo sapiens	109-112
22412871-6	2012	Furthermore, ESC-derived factors robustly suppressed T cell proliferation in response to the protein kinase C-theta (PKC-theta) activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	138-169	protein kinase C theta	Homo sapiens	93-115
22412871-6	2012	Furthermore, ESC-derived factors robustly suppressed T cell proliferation in response to the protein kinase C-theta (PKC-theta) activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	138-169	protein kinase C theta	Homo sapiens	117-126
22299029-0	2012	Differential role of PKC-induced c-Jun in HTLV-1 LTR activation by 12-O-tetradecanoylphorbol-13-acetate in different human T-cell lines.	Tetradecanoylphorbol Acetate	67-103	protein kinase C alpha	Homo sapiens	21-24
22299029-1	2012	We have previously shown that TPA activates HTLV-1 LTR in Jurkat T-cells by inducing the binding of Sp1-p53 complex to the Sp1 site residing within the Ets responsive region 1 (ERR-1) of the LTR and that this activation is inhibited by PKCalpha and PKCepsilon.	Tetradecanoylphorbol Acetate	30-33	tumor protein p53	Homo sapiens	104-107
22299029-1	2012	We have previously shown that TPA activates HTLV-1 LTR in Jurkat T-cells by inducing the binding of Sp1-p53 complex to the Sp1 site residing within the Ets responsive region 1 (ERR-1) of the LTR and that this activation is inhibited by PKCalpha and PKCepsilon.	Tetradecanoylphorbol Acetate	30-33	protein kinase C alpha	Homo sapiens	236-244
22355730-2	2012	In this study, we found that patients with tuberculosis had decreased PMA/ionomycin stimulated multifunctional CD4 T cells, and increased Mycobacterium tuberculosis antigen-specific multifunctional CD4 T cells, when compared to individuals with latent tuberculosis infection and healthy controls.	Tetradecanoylphorbol Acetate	70-73	CD4 molecule	Homo sapiens	111-114
22355730-3	2012	PMA/ionomycin stimulated IFN-gamma+IL-2+TNF-alpha+ CD4 T cell responses were decreased in patients with smear-positive tuberculosis compared to those with smear-negative tuberculosis.	Tetradecanoylphorbol Acetate	0-3	interferon gamma	Homo sapiens	25-34
22355730-3	2012	PMA/ionomycin stimulated IFN-gamma+IL-2+TNF-alpha+ CD4 T cell responses were decreased in patients with smear-positive tuberculosis compared to those with smear-negative tuberculosis.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Homo sapiens	35-39
22355730-3	2012	PMA/ionomycin stimulated IFN-gamma+IL-2+TNF-alpha+ CD4 T cell responses were decreased in patients with smear-positive tuberculosis compared to those with smear-negative tuberculosis.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	40-49
22355730-3	2012	PMA/ionomycin stimulated IFN-gamma+IL-2+TNF-alpha+ CD4 T cell responses were decreased in patients with smear-positive tuberculosis compared to those with smear-negative tuberculosis.	Tetradecanoylphorbol Acetate	0-3	CD4 molecule	Homo sapiens	51-54
21842414-3	2011	Using human hepatoma HepG2 as a model, we have found reactive oxygen species (ROS) may cooperate with protein kinase C (PKC) for sustained ERK phosphorylation and migration of HepG2 induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	193-230	protein kinase C alpha	Homo sapiens	120-123
22001118-7	2011	While the PKC agonist, PMA, did not affect GR internalization when tested alone, it increased glucagon-mediated GR internalization by 25-40% in GR-expressing HEK-293 cells (HEK-GR cells).	Tetradecanoylphorbol Acetate	23-26	protein kinase C alpha	Homo sapiens	10-13
21940941-7	2011	Moreover, a significant decrease in catalase mRNA levels was observed in PMNs after phorbol 12-myristate 13-acetate incubation.	Tetradecanoylphorbol Acetate	84-115	catalase	Homo sapiens	36-44
21842414-9	2011	Taken together, ROS mediated cross talk of PKC and integrin for migration of HepG2 induced by TPA.	Tetradecanoylphorbol Acetate	94-97	protein kinase C alpha	Homo sapiens	43-46
22363712-3	2012	TGF-beta was essential for Th9 cell differentiation from naive CD4(+) T cells stimulated with PMA and ionomycin in vitro for 5 h, and addition of IL-1beta, IL-4 or IL-6 further augmented Th9 cell differentiation.	Tetradecanoylphorbol Acetate	94-97	transforming growth factor beta 1	Homo sapiens	0-8
22001563-0	2011	Attenuation of experimental TPA-induced dermatitis by acetylenic acetogenins is associated with inhibition of PLA2 activity.	Tetradecanoylphorbol Acetate	28-31	phospholipase A2 group IB	Homo sapiens	110-114
21810446-9	2011	PKCtheta inhibition (by pseudostrate-inhibitor or dominant negative) inhibited CCK- and TPA-stimulation of PKD, Src, RafC, PYK2, p125(FAK) and IKKalpha/beta, but not basal/stimulated enzyme secretion.	Tetradecanoylphorbol Acetate	88-91	protein tyrosine kinase 2 beta	Rattus norvegicus	123-127
21810446-9	2011	PKCtheta inhibition (by pseudostrate-inhibitor or dominant negative) inhibited CCK- and TPA-stimulation of PKD, Src, RafC, PYK2, p125(FAK) and IKKalpha/beta, but not basal/stimulated enzyme secretion.	Tetradecanoylphorbol Acetate	88-91	inhibitor of nuclear factor kappa B kinase subunit beta	Rattus norvegicus	143-156
21810446-10	2011	Also CCK- and TPA-induced PKCtheta activation produced an increment in PKCtheta"s direct association with AKT, RafA, RafC and Lyn.	Tetradecanoylphorbol Acetate	14-17	AKT serine/threonine kinase 1	Rattus norvegicus	106-109
21810446-10	2011	Also CCK- and TPA-induced PKCtheta activation produced an increment in PKCtheta"s direct association with AKT, RafA, RafC and Lyn.	Tetradecanoylphorbol Acetate	14-17	LYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	126-129
22001392-5	2011	We first demonstrate that AP-1 activation by 12-O-tetradecanoylphorbol-13-acetate induces PTPROt expression with concurrent recruitment of c-fos and c-jun to its promoter.	Tetradecanoylphorbol Acetate	45-81	protein tyrosine phosphatase, receptor type, O	Mus musculus	90-96
21818684-6	2011	Sustained exposure to phorbol myristate acetate (PMA) also decreased ET-1 secretion.	Tetradecanoylphorbol Acetate	22-47	endothelin 1	Rattus norvegicus	69-73
21818684-6	2011	Sustained exposure to phorbol myristate acetate (PMA) also decreased ET-1 secretion.	Tetradecanoylphorbol Acetate	49-52	endothelin 1	Rattus norvegicus	69-73
22160590-5	2011	Treatment with TPA modified the activity of phosphoPKCalpha and caused an increase of the Snail family members Snail, Slug and Smad-interacting protein 1 and a decrease of E-cadherin.	Tetradecanoylphorbol Acetate	15-18	snail family transcriptional repressor 1	Homo sapiens	90-95
22160590-5	2011	Treatment with TPA modified the activity of phosphoPKCalpha and caused an increase of the Snail family members Snail, Slug and Smad-interacting protein 1 and a decrease of E-cadherin.	Tetradecanoylphorbol Acetate	15-18	snail family transcriptional repressor 1	Homo sapiens	111-116
22160590-5	2011	Treatment with TPA modified the activity of phosphoPKCalpha and caused an increase of the Snail family members Snail, Slug and Smad-interacting protein 1 and a decrease of E-cadherin.	Tetradecanoylphorbol Acetate	15-18	cadherin 1	Homo sapiens	172-182
22160590-6	2011	In HPAC cells treated with TPA, downregulation of claudin-1 and mislocalization of claudin-4 and occludin around the nuclei were observed, together with a decrease in the numbers of tight junction strands and an increase in phosphorylation of claudin-4.	Tetradecanoylphorbol Acetate	27-30	claudin 4	Homo sapiens	83-92
22160590-6	2011	In HPAC cells treated with TPA, downregulation of claudin-1 and mislocalization of claudin-4 and occludin around the nuclei were observed, together with a decrease in the numbers of tight junction strands and an increase in phosphorylation of claudin-4.	Tetradecanoylphorbol Acetate	27-30	claudin 4	Homo sapiens	243-252
22160590-8	2011	All such changes after TPA treatment were prevented by inhibitors of panPKC and PKCalpha.	Tetradecanoylphorbol Acetate	23-26	protein kinase C alpha	Homo sapiens	69-88
21842414-3	2011	Using human hepatoma HepG2 as a model, we have found reactive oxygen species (ROS) may cooperate with protein kinase C (PKC) for sustained ERK phosphorylation and migration of HepG2 induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	193-230	mitogen-activated protein kinase 1	Homo sapiens	139-142
21842414-3	2011	Using human hepatoma HepG2 as a model, we have found reactive oxygen species (ROS) may cooperate with protein kinase C (PKC) for sustained ERK phosphorylation and migration of HepG2 induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	232-235	protein kinase C alpha	Homo sapiens	120-123
21842414-5	2011	Various antagonists of integrin signaling prevented TPA-induced activation of ERK and PKC, ROS generation and migration of HepG2.	Tetradecanoylphorbol Acetate	52-55	mitogen-activated protein kinase 1	Homo sapiens	78-81
22232712-0	2011	The Effect of Doxycycline on PMA-Induced MUC5B Expression via MMP-9 and p38 in NCI-H292 Cells.	Tetradecanoylphorbol Acetate	29-32	mitogen-activated protein kinase 14	Homo sapiens	72-75
21842414-5	2011	Various antagonists of integrin signaling prevented TPA-induced activation of ERK and PKC, ROS generation and migration of HepG2.	Tetradecanoylphorbol Acetate	52-55	protein kinase C alpha	Homo sapiens	86-89
22232712-11	2011	CONCLUSION: The results of this study suggest that doxycycline inhibited PMA-induced MUC5B mRNA expression and protein production through the MMP-9 and p38 pathways in human NCI-H292 airway epithelial cells.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase 14	Homo sapiens	152-155
21842414-6	2011	On the other hand, TPA-induced phosphorylation of integrin signaling components including focal adhesion kinase (FAK), Src (Tyr416) and paxillin (Tyr31 and Ser178) can be prevented by PKC inhibitor Bisindolylmaleimides (BIS) and antioxidant dithiotheritol (DTT).	Tetradecanoylphorbol Acetate	19-22	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	119-122
21937661-6	2011	We identified a subset of CD8(+) T cells refractory to phorbol 12-myristate 13-acetate plus ionomycin-induced ERK1/2 phosphorylation (referred to as p-ERK1/2-refractory cells) that was greatly expanded in HIV-1-infected adults.	Tetradecanoylphorbol Acetate	55-86	mitogen-activated protein kinase 3	Homo sapiens	151-157
21877189-2	2011	Changes in the inflammatory profiles of lipopolysaccharide (LPS)-activated phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophage models were investigated following SGlc treatment.	Tetradecanoylphorbol Acetate	75-106	GLI family zinc finger 2	Homo sapiens	128-133
21877189-2	2011	Changes in the inflammatory profiles of lipopolysaccharide (LPS)-activated phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophage models were investigated following SGlc treatment.	Tetradecanoylphorbol Acetate	108-111	GLI family zinc finger 2	Homo sapiens	128-133
21933938-4	2011	Interactions among carbachol, PKC inhibitors, phorbol 12-myristate 13-acetate, and thapsigargin to modulate [Ca(2+)](i) implicated conventional PKC isoforms in mediating sustained secretion.	Tetradecanoylphorbol Acetate	46-77	proline rich transmembrane protein 2	Homo sapiens	144-147
22346774-0	2011	NDRG2 Promotes GATA-1 Expression through Regulation of the JAK2/STAT Pathway in PMA-stimulated U937 Cells.	Tetradecanoylphorbol Acetate	80-83	GATA binding protein 1	Homo sapiens	15-21
21400615-6	2011	Importantly, 5"-NIO inhibited Pin1 phosphorylation at serine 16 induced by EGF or TPA, respectively, resulted in the inhibition of interaction between Pin1 and Raf-1.	Tetradecanoylphorbol Acetate	82-85	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	30-34
21994461-8	2011	Following global stimulation with phorbol myristate acetate (PMA)-ionomycin, we noted a significant interleukin 2 (IL-2) deficit in both cervical and blood CD4 T cells from HIV-infected women compared to uninfected women, while gamma interferon (IFN-gamma) production was similar, irrespective of HIV status.	Tetradecanoylphorbol Acetate	61-64	interleukin 2	Homo sapiens	100-113
21994461-8	2011	Following global stimulation with phorbol myristate acetate (PMA)-ionomycin, we noted a significant interleukin 2 (IL-2) deficit in both cervical and blood CD4 T cells from HIV-infected women compared to uninfected women, while gamma interferon (IFN-gamma) production was similar, irrespective of HIV status.	Tetradecanoylphorbol Acetate	61-64	interleukin 2	Homo sapiens	115-119
21994461-8	2011	Following global stimulation with phorbol myristate acetate (PMA)-ionomycin, we noted a significant interleukin 2 (IL-2) deficit in both cervical and blood CD4 T cells from HIV-infected women compared to uninfected women, while gamma interferon (IFN-gamma) production was similar, irrespective of HIV status.	Tetradecanoylphorbol Acetate	61-64	CD4 molecule	Homo sapiens	156-159
21994461-8	2011	Following global stimulation with phorbol myristate acetate (PMA)-ionomycin, we noted a significant interleukin 2 (IL-2) deficit in both cervical and blood CD4 T cells from HIV-infected women compared to uninfected women, while gamma interferon (IFN-gamma) production was similar, irrespective of HIV status.	Tetradecanoylphorbol Acetate	61-64	interferon gamma	Homo sapiens	228-255
21994461-8	2011	Following global stimulation with phorbol myristate acetate (PMA)-ionomycin, we noted a significant interleukin 2 (IL-2) deficit in both cervical and blood CD4 T cells from HIV-infected women compared to uninfected women, while gamma interferon (IFN-gamma) production was similar, irrespective of HIV status.	Tetradecanoylphorbol Acetate	34-59	interleukin 2	Homo sapiens	100-113
21994461-8	2011	Following global stimulation with phorbol myristate acetate (PMA)-ionomycin, we noted a significant interleukin 2 (IL-2) deficit in both cervical and blood CD4 T cells from HIV-infected women compared to uninfected women, while gamma interferon (IFN-gamma) production was similar, irrespective of HIV status.	Tetradecanoylphorbol Acetate	34-59	interleukin 2	Homo sapiens	115-119
21994461-8	2011	Following global stimulation with phorbol myristate acetate (PMA)-ionomycin, we noted a significant interleukin 2 (IL-2) deficit in both cervical and blood CD4 T cells from HIV-infected women compared to uninfected women, while gamma interferon (IFN-gamma) production was similar, irrespective of HIV status.	Tetradecanoylphorbol Acetate	34-59	CD4 molecule	Homo sapiens	156-159
21994461-8	2011	Following global stimulation with phorbol myristate acetate (PMA)-ionomycin, we noted a significant interleukin 2 (IL-2) deficit in both cervical and blood CD4 T cells from HIV-infected women compared to uninfected women, while gamma interferon (IFN-gamma) production was similar, irrespective of HIV status.	Tetradecanoylphorbol Acetate	34-59	interferon gamma	Homo sapiens	228-255
21400615-6	2011	Importantly, 5"-NIO inhibited Pin1 phosphorylation at serine 16 induced by EGF or TPA, respectively, resulted in the inhibition of interaction between Pin1 and Raf-1.	Tetradecanoylphorbol Acetate	82-85	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	151-155
21400615-8	2011	Together, these findings suggest that 5"-NIO might act as an anticarcinogene in EGF- or TPA-induced carcinogenesis through the inhibition of interaction between Pin1 and Raf-1.	Tetradecanoylphorbol Acetate	88-91	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	161-165
21961727-6	2011	We successfully applied this assay system to monitor changes in FXIII and TG2 activities in THP-1 monocytic cells differentiated with phorbol 12-myristate13-acetate and interleukin-4.	Tetradecanoylphorbol Acetate	134-164	transglutaminase 2	Homo sapiens	74-77
21964610-7	2011	Histopathological findings of tumors found in PAT/TPA treated mice showed that these tumors were of squamous cell carcinoma type and similar to those found in the positive control group (DMBA/TPA) along with significant increase of lipid peroxidation and decrease in free sulfydryls, catalase, superoxide dismutase and glutathione reductase activities.	Tetradecanoylphorbol Acetate	50-53	catalase	Mus musculus	284-292
21925496-3	2011	The present study aimed to investigate the modulating effects of cilostazol on monocyte invasion and the gene expressions of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1.	Tetradecanoylphorbol Acetate	223-254	TIMP metallopeptidase inhibitor 1	Homo sapiens	164-210
21925496-3	2011	The present study aimed to investigate the modulating effects of cilostazol on monocyte invasion and the gene expressions of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1.	Tetradecanoylphorbol Acetate	223-254	TIMP metallopeptidase inhibitor 1	Homo sapiens	212-218
21925496-3	2011	The present study aimed to investigate the modulating effects of cilostazol on monocyte invasion and the gene expressions of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1.	Tetradecanoylphorbol Acetate	256-259	TIMP metallopeptidase inhibitor 1	Homo sapiens	212-218
21930713-7	2011	Given that PMA-mediated apoptosis is thought to result from up-regulation of TNFalpha, which then activates TNFR1, we next evaluated the alpha2-6 sialylation of TNFR1.	Tetradecanoylphorbol Acetate	11-14	tumor necrosis factor	Mus musculus	77-85
21903576-5	2011	SSeCKS-null mouse embryo fibroblasts displayed increased relative basal and phorbol ester (phorbol 12-myristate 13-acetate)-induced PKC activity but were defective in phorbol 12-myristate 13-acetate-induced actin cytoskeletal reorganization and cell shape change; these responses could be rescued by the forced expression of full-length SSeCKS but not by an SSeCKS variant deleted of its PKC-binding domains.	Tetradecanoylphorbol Acetate	91-122	protein kinase C alpha	Homo sapiens	132-135
21795061-7	2011	Ketamine and MK-801 decreased TH1 cells, TH2 cells, IFN-gamma and IL-4 levels but increased the ratio of TH1/TH2 and IFN-gamma/IL-4 in the presence of PMA and ionomycin.	Tetradecanoylphorbol Acetate	151-154	interferon gamma	Homo sapiens	117-126
21827582-9	2011	Additional in vivo experiments suggested that L1-RTP occurred during tumor promotion by TPA.	Tetradecanoylphorbol Acetate	88-91	immunoglobulin kappa variable 1-16	Homo sapiens	46-48
22009531-6	2011	Exposure to DMBA and TPA activated p53 and decreased MnSOD expression via p53-mediated suppression of Sp1 binding to the MnSOD promoter in normal-appearing skin and benign papillomas.	Tetradecanoylphorbol Acetate	21-24	tumor protein p53	Homo sapiens	35-38
22009531-6	2011	Exposure to DMBA and TPA activated p53 and decreased MnSOD expression via p53-mediated suppression of Sp1 binding to the MnSOD promoter in normal-appearing skin and benign papillomas.	Tetradecanoylphorbol Acetate	21-24	tumor protein p53	Homo sapiens	74-77
21839858-5	2011	Subsequently, over-expression of HMBOX1 significantly inhibited the expression and production of IFN-gamma in NK cells in response to the stimulation of tumor cell K562 or PMA/ionomycin.	Tetradecanoylphorbol Acetate	172-175	interferon gamma	Homo sapiens	97-106
21907277-2	2011	First, we observed that treatment of Chang liver (CHL) cells with various COX-2 inducers increased reactive oxygen species (ROS) production concomitant with GSH depletion, phorbol 12-myristate 13-acetate (PMA) being the most effective treatment.	Tetradecanoylphorbol Acetate	172-203	prostaglandin-endoperoxide synthase 2	Homo sapiens	74-79
21907277-2	2011	First, we observed that treatment of Chang liver (CHL) cells with various COX-2 inducers increased reactive oxygen species (ROS) production concomitant with GSH depletion, phorbol 12-myristate 13-acetate (PMA) being the most effective treatment.	Tetradecanoylphorbol Acetate	205-208	prostaglandin-endoperoxide synthase 2	Homo sapiens	74-79
22234062-1	2011	BACKGROUND/AIMS: Urokinase (uPA) is a serine protease, which together with uPAR, tPA, PAI 1 and PAI 2 forms the plasminogen activator system, a component of metastatic cascade contributing to the invasive growth and angiogenesis of malignant tumours.	Tetradecanoylphorbol Acetate	81-84	proline rich acidic protein 1	Homo sapiens	28-31
22126767-3	2011	RESULTS: TPA reduced the efficiency of FRET and increased the emission ratio of CFP/YFP (C/Y) in HEK293 cells transfected with CKAR.	Tetradecanoylphorbol Acetate	9-12	complement factor properdin	Homo sapiens	80-83
21734098-9	2011	In addition, AGE-BSA or suppression of NRP1 both reduced the phosphorylation of focal adhesion kinase (FAK) and Erk1/2 in PMA-stimulated differentiated podocytes.	Tetradecanoylphorbol Acetate	122-125	neuropilin 1	Mus musculus	39-43
21980194-1	2011	BACKGROUND AND PURPOSE: Use of intravenous tissue-type plasminogen activator (IV tPA) for acute ischemic stroke is restricted to patients with an international normalized ratio (INR) less than 1.7.	Tetradecanoylphorbol Acetate	81-84	plasminogen activator, tissue type	Homo sapiens	43-76
21689256-3	2011	Phorbol 12-myristate 13-acetate (PMA) is known to enhance the percentage of fusion-competent vesicles and this is mediated by protein kinase C (PKC)-independent Munc13-1 activation and PKC-dependent dissociation of Munc18-1 from syntaxin 1a.	Tetradecanoylphorbol Acetate	0-31	unc-13 homolog A	Homo sapiens	161-169
21786025-11	2011	Based on above results, Ang II may induced cerebral aneurysm, ischemia/infarction on brain through RAS system by down regulating the mRNA levels of MMP 2, uPA, PAI, PPAR-A, MCSF1 and up regulating tPA and MCP-1 and beta carotene attenuates the disease condition and bring down to normal expression levels of above genes.	Tetradecanoylphorbol Acetate	197-200	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	24-30
21771721-5	2011	12-O-tetradecanoylphorbol 13-acetate-induced differentiation of human U937 monocytes increased the expression and secretion of inflammatory cytokines such as tumor necrosis factor alpha, interleukin (IL)-6 and IL-8.	Tetradecanoylphorbol Acetate	0-36	tumor necrosis factor	Homo sapiens	158-185
21771721-5	2011	12-O-tetradecanoylphorbol 13-acetate-induced differentiation of human U937 monocytes increased the expression and secretion of inflammatory cytokines such as tumor necrosis factor alpha, interleukin (IL)-6 and IL-8.	Tetradecanoylphorbol Acetate	0-36	interleukin 6	Homo sapiens	187-205
21771721-5	2011	12-O-tetradecanoylphorbol 13-acetate-induced differentiation of human U937 monocytes increased the expression and secretion of inflammatory cytokines such as tumor necrosis factor alpha, interleukin (IL)-6 and IL-8.	Tetradecanoylphorbol Acetate	0-36	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
21426336-5	2011	The effect of nampt on lipid accumulation was examined in phorbol myristate acetate-differentiated THP-1 and in primary monocyte-derived macrophages.	Tetradecanoylphorbol Acetate	58-83	GLI family zinc finger 2	Homo sapiens	99-104
21689256-3	2011	Phorbol 12-myristate 13-acetate (PMA) is known to enhance the percentage of fusion-competent vesicles and this is mediated by protein kinase C (PKC)-independent Munc13-1 activation and PKC-dependent dissociation of Munc18-1 from syntaxin 1a.	Tetradecanoylphorbol Acetate	33-36	unc-13 homolog A	Homo sapiens	161-169
21807015-4	2011	Our results showed that among the tested molecules, all sensitizers specifically prevent the production of PMA/LPS-induced COX-2 metabolites (PGE(2,) TxB(2) and PGD(2)), eugenol and cinnamaldehyde inhibiting also the production of IL-1beta and TNF-alpha.	Tetradecanoylphorbol Acetate	107-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-128
21807015-4	2011	Our results showed that among the tested molecules, all sensitizers specifically prevent the production of PMA/LPS-induced COX-2 metabolites (PGE(2,) TxB(2) and PGD(2)), eugenol and cinnamaldehyde inhibiting also the production of IL-1beta and TNF-alpha.	Tetradecanoylphorbol Acetate	107-110	interleukin 1 beta	Homo sapiens	231-239
21878491-6	2011	Mutating these two serine residues into alanine residues abrogates PMA-induced redistribution of SH2B1beta out of focal adhesions, decreases SH2B1beta cycling into and out of focal adhesions in control and GH-stimulated cells, and increases the size of focal adhesions.	Tetradecanoylphorbol Acetate	67-70	growth hormone 1	Homo sapiens	206-208
21807015-4	2011	Our results showed that among the tested molecules, all sensitizers specifically prevent the production of PMA/LPS-induced COX-2 metabolites (PGE(2,) TxB(2) and PGD(2)), eugenol and cinnamaldehyde inhibiting also the production of IL-1beta and TNF-alpha.	Tetradecanoylphorbol Acetate	107-110	tumor necrosis factor	Homo sapiens	244-253
21763267-7	2011	ATP-dependent p-Akt was diminished by TPA and augmented by Ro318220 treatment in a Ca2+-containing but not in a Ca2+-free medium.	Tetradecanoylphorbol Acetate	38-41	AKT serine/threonine kinase 1	Rattus norvegicus	16-19
21624785-7	2011	Because we had previously shown that PMA-mediated augmentation of I(NMDA) of NMDARs expressed in these cells is by activation of PKCalpha, we assessed the effect of ethanol (1, 10, 50, and 100 mM) on PKCalpha activity.	Tetradecanoylphorbol Acetate	37-40	protein kinase C alpha	Homo sapiens	129-137
21730054-12	2011	U0126, an MEK inhibitor, and DPQ, a poly(ADP-ribose) polymerase-1 inhibitor, suppressed PMA-induced up-regulation of H1R gene expression.	Tetradecanoylphorbol Acetate	88-91	mitogen-activated protein kinase kinase 7	Homo sapiens	10-13
21730054-12	2011	U0126, an MEK inhibitor, and DPQ, a poly(ADP-ribose) polymerase-1 inhibitor, suppressed PMA-induced up-regulation of H1R gene expression.	Tetradecanoylphorbol Acetate	88-91	poly(ADP-ribose) polymerase 1	Homo sapiens	36-65
21730054-16	2011	These results suggest the involvement of the PKCdelta/ERK/poly(ADP-ribose) polymerase-1 signaling pathway in histamine- or PMA-induced up-regulation of H1R gene expression in HeLa cells.	Tetradecanoylphorbol Acetate	123-126	mitogen-activated protein kinase 1	Homo sapiens	54-57
21730054-16	2011	These results suggest the involvement of the PKCdelta/ERK/poly(ADP-ribose) polymerase-1 signaling pathway in histamine- or PMA-induced up-regulation of H1R gene expression in HeLa cells.	Tetradecanoylphorbol Acetate	123-126	poly(ADP-ribose) polymerase 1	Homo sapiens	58-87
21624785-7	2011	Because we had previously shown that PMA-mediated augmentation of I(NMDA) of NMDARs expressed in these cells is by activation of PKCalpha, we assessed the effect of ethanol (1, 10, 50, and 100 mM) on PKCalpha activity.	Tetradecanoylphorbol Acetate	37-40	protein kinase C alpha	Homo sapiens	200-208
21624785-9	2011	The data suggest that ethanol disruption of PMA-mediated augmentation of I(NMDA) may be due to a decrease in PKCalpha activity by ethanol.	Tetradecanoylphorbol Acetate	44-47	protein kinase C alpha	Homo sapiens	109-117
21705673-7	2011	Furthermore, we found that ACh treatment activated protein kinase C (PKC) alpha, and inhibition of PKCalpha activity by the specific inhibitor Go-6976, or expression of a kinase-dead mutant of PKCalpha but not PKCepsilon or downregulation of PKCalpha expression by chronic 12-O-tetradecanoylphorbol-13-acetate treatment, completely abolished ACh-induced calcium influx.	Tetradecanoylphorbol Acetate	273-309	protein kinase C, alpha	Mus musculus	99-107
21705673-7	2011	Furthermore, we found that ACh treatment activated protein kinase C (PKC) alpha, and inhibition of PKCalpha activity by the specific inhibitor Go-6976, or expression of a kinase-dead mutant of PKCalpha but not PKCepsilon or downregulation of PKCalpha expression by chronic 12-O-tetradecanoylphorbol-13-acetate treatment, completely abolished ACh-induced calcium influx.	Tetradecanoylphorbol Acetate	273-309	protein kinase C, alpha	Mus musculus	193-201
21705673-7	2011	Furthermore, we found that ACh treatment activated protein kinase C (PKC) alpha, and inhibition of PKCalpha activity by the specific inhibitor Go-6976, or expression of a kinase-dead mutant of PKCalpha but not PKCepsilon or downregulation of PKCalpha expression by chronic 12-O-tetradecanoylphorbol-13-acetate treatment, completely abolished ACh-induced calcium influx.	Tetradecanoylphorbol Acetate	273-309	protein kinase C, alpha	Mus musculus	193-201
21480395-10	2011	We also performed ELISAs and discovered significant up-regulation of IL-8 and VEGF secretion by UMSCC 11A after treatment with phorbol 12-myristate 13-acetate, tumor necrosis factor alpha, and CSC, which was down-regulated by the A-Fos dominant negative protein.	Tetradecanoylphorbol Acetate	127-158	vascular endothelial growth factor A	Homo sapiens	78-82
21664396-2	2011	Herein, the in vitro function of separated CD3(+)CD4(+)CD25(+)Foxp3(+)IFN-gamma(+) PBL that were induced by phorbol 12-myristate 13-acetate (PMA)/ionomycin or alloantigenic stimulation was investigated using cell coculture techniques and flow cytometry.	Tetradecanoylphorbol Acetate	108-139	CD4 molecule	Homo sapiens	49-52
21664396-2	2011	Herein, the in vitro function of separated CD3(+)CD4(+)CD25(+)Foxp3(+)IFN-gamma(+) PBL that were induced by phorbol 12-myristate 13-acetate (PMA)/ionomycin or alloantigenic stimulation was investigated using cell coculture techniques and flow cytometry.	Tetradecanoylphorbol Acetate	108-139	interferon gamma	Homo sapiens	70-79
21664396-2	2011	Herein, the in vitro function of separated CD3(+)CD4(+)CD25(+)Foxp3(+)IFN-gamma(+) PBL that were induced by phorbol 12-myristate 13-acetate (PMA)/ionomycin or alloantigenic stimulation was investigated using cell coculture techniques and flow cytometry.	Tetradecanoylphorbol Acetate	141-144	CD4 molecule	Homo sapiens	49-52
21664396-2	2011	Herein, the in vitro function of separated CD3(+)CD4(+)CD25(+)Foxp3(+)IFN-gamma(+) PBL that were induced by phorbol 12-myristate 13-acetate (PMA)/ionomycin or alloantigenic stimulation was investigated using cell coculture techniques and flow cytometry.	Tetradecanoylphorbol Acetate	141-144	interferon gamma	Homo sapiens	70-79
21664396-3	2011	CD4(+)CD25(+)Foxp3(+) PBL with intracellular IFN-gamma production increased to 26% in cell cultures stimulated with PMA/ionomycin for 6 hours.	Tetradecanoylphorbol Acetate	116-119	CD4 molecule	Homo sapiens	0-3
21664396-3	2011	CD4(+)CD25(+)Foxp3(+) PBL with intracellular IFN-gamma production increased to 26% in cell cultures stimulated with PMA/ionomycin for 6 hours.	Tetradecanoylphorbol Acetate	116-119	interferon gamma	Homo sapiens	45-54
21804018-8	2011	IRAK1/4 inhibitors, their small interfering RNAs, and JNK inhibitor also attenuated PMA-induced IL-1beta production.	Tetradecanoylphorbol Acetate	84-87	mitogen-activated protein kinase 8	Homo sapiens	54-57
21804018-8	2011	IRAK1/4 inhibitors, their small interfering RNAs, and JNK inhibitor also attenuated PMA-induced IL-1beta production.	Tetradecanoylphorbol Acetate	84-87	interleukin 1 beta	Homo sapiens	96-104
21526343-2	2011	Previous reports showed that the presence of phorbol 12-myristate 13-acetate (PMA) caused a significant increase in RGN mRNA expression and promoter activity in rat hepatoma cells.	Tetradecanoylphorbol Acetate	45-76	regucalcin	Rattus norvegicus	116-119
21526343-2	2011	Previous reports showed that the presence of phorbol 12-myristate 13-acetate (PMA) caused a significant increase in RGN mRNA expression and promoter activity in rat hepatoma cells.	Tetradecanoylphorbol Acetate	78-81	regucalcin	Rattus norvegicus	116-119
21596133-7	2011	Conversely, PKC activator phorbol ester (PMA) enhanced the expression level of another ERRalpha-target gene pyruvate dehydrogenase kinase 4 (PDK4).	Tetradecanoylphorbol Acetate	41-44	estrogen related receptor alpha	Homo sapiens	87-95
21596133-7	2011	Conversely, PKC activator phorbol ester (PMA) enhanced the expression level of another ERRalpha-target gene pyruvate dehydrogenase kinase 4 (PDK4).	Tetradecanoylphorbol Acetate	41-44	pyruvate dehydrogenase kinase 4	Homo sapiens	108-139
21596133-7	2011	Conversely, PKC activator phorbol ester (PMA) enhanced the expression level of another ERRalpha-target gene pyruvate dehydrogenase kinase 4 (PDK4).	Tetradecanoylphorbol Acetate	41-44	pyruvate dehydrogenase kinase 4	Homo sapiens	141-145
21142820-5	2011	Apigenin significantly inhibits the inductive effect of phorbol 12-myristate 13-acetate (PMA) plus A23187 on the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF).	Tetradecanoylphorbol Acetate	56-87	tumor necrosis factor	Homo sapiens	158-191
21142820-5	2011	Apigenin significantly inhibits the inductive effect of phorbol 12-myristate 13-acetate (PMA) plus A23187 on the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF).	Tetradecanoylphorbol Acetate	56-87	C-X-C motif chemokine ligand 8	Homo sapiens	193-211
21142820-5	2011	Apigenin significantly inhibits the inductive effect of phorbol 12-myristate 13-acetate (PMA) plus A23187 on the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF).	Tetradecanoylphorbol Acetate	56-87	interleukin 6	Homo sapiens	213-217
21804018-4	2011	Moreover, PMA-induced IL-1beta production was significantly reduced in the presence of TLR2, TLR4, and CD11b Abs.	Tetradecanoylphorbol Acetate	10-13	interleukin 1 beta	Homo sapiens	22-30
21804018-4	2011	Moreover, PMA-induced IL-1beta production was significantly reduced in the presence of TLR2, TLR4, and CD11b Abs.	Tetradecanoylphorbol Acetate	10-13	toll like receptor 2	Homo sapiens	87-91
21804018-5	2011	Rottlerin, a PKCdelta-specific inhibitor, significantly reduced PMA-induced IL-1beta production as well as CD11b, TLR2 expression, and IRAK1-JNK activation.	Tetradecanoylphorbol Acetate	64-67	interleukin 1 beta	Homo sapiens	76-84
21682666-7	2011	Activation of PKC with phorbol-12-myristate-13-acetate (PMA) imitated the effect of insulin and was not affected by inhibition of PI3K.	Tetradecanoylphorbol Acetate	23-54	insulin	Homo sapiens	84-91
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	43-79	protein kinase C alpha	Homo sapiens	35-38
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	43-79	forkhead box O3	Homo sapiens	168-174
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	43-79	protein kinase C alpha	Homo sapiens	178-187
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	43-79	protein kinase C alpha	Homo sapiens	178-181
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	43-79	AKT serine/threonine kinase 1	Homo sapiens	240-243
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	81-84	protein kinase C alpha	Homo sapiens	35-38
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	81-84	forkhead box O3	Homo sapiens	168-174
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	81-84	protein kinase C alpha	Homo sapiens	178-187
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	81-84	protein kinase C alpha	Homo sapiens	178-181
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	81-84	AKT serine/threonine kinase 1	Homo sapiens	240-243
21705328-1	2011	12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors.	Tetradecanoylphorbol Acetate	0-36	protein kinase C alpha	Homo sapiens	217-220
21705328-1	2011	12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors.	Tetradecanoylphorbol Acetate	38-41	protein kinase C alpha	Homo sapiens	217-220
21705328-3	2011	TPA-induced generation of reactive oxygen species (ROS) was blocked by pretreatment of the PKC inhibitor BIM and NADPH oxidase inhibitor DPI.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	91-94
21705328-4	2011	Small interfering RNA (siRNA) experiments indicated that knocking down the NADPH oxidase components e.g. Rac1, p22(phox), p67(phox), and NOXO1 in A549 cells impaired TPA-induced MnSOD expression.	Tetradecanoylphorbol Acetate	166-169	CD33 molecule	Homo sapiens	122-125
21705328-5	2011	To identify the PKC isozyme involved, we used a sod2 gene response reporter plasmid, pSODLUC-3340-I2E-C, capable of sensing the effect of TNF-alpha and TPA, to monitor the effects of PKC isozyme-specific inhibitors and siRNA-induced knockdown of specific PKC isozyme.	Tetradecanoylphorbol Acetate	152-155	protein kinase C alpha	Homo sapiens	16-19
21705328-6	2011	Our data indicate that TPA-induced MnSOD expression was independent of p53 and most likely mediated by PKC-alpha-, and -epsilon-dependent signaling pathways.	Tetradecanoylphorbol Acetate	23-26	tumor protein p53	Homo sapiens	71-74
21705328-6	2011	Our data indicate that TPA-induced MnSOD expression was independent of p53 and most likely mediated by PKC-alpha-, and -epsilon-dependent signaling pathways.	Tetradecanoylphorbol Acetate	23-26	protein kinase C alpha	Homo sapiens	103-112
21705328-7	2011	Furthermore, siRNA-induced knock-down of CREB and Forkhead box class O (FOXO) 3a led to a reduction in TPA-induced MnSOD gene expression.	Tetradecanoylphorbol Acetate	103-106	forkhead box O3	Homo sapiens	72-76
21705328-8	2011	Together, our results revealed that TPA up-regulates, in part, two PKC-dependent transcriptional pathways to induce MnSOD expression.	Tetradecanoylphorbol Acetate	36-39	protein kinase C alpha	Homo sapiens	67-70
21723850-1	2011	12-O-tetradecanoyl phorbol-13-acetate-induced sequence 7/interferon related development regulator 1 (Tis7/IFRD1) has been recently identified as a modifier gene in lung inflammatory disease severity in patients with cystic fibrosis (CF), based upon its capacity to regulate inflammatory activities in neutrophils.	Tetradecanoylphorbol Acetate	0-37	interferon related developmental regulator 1	Homo sapiens	101-105
21723850-1	2011	12-O-tetradecanoyl phorbol-13-acetate-induced sequence 7/interferon related development regulator 1 (Tis7/IFRD1) has been recently identified as a modifier gene in lung inflammatory disease severity in patients with cystic fibrosis (CF), based upon its capacity to regulate inflammatory activities in neutrophils.	Tetradecanoylphorbol Acetate	0-37	interferon related developmental regulator 1	Homo sapiens	106-111
21525431-8	2011	Furthermore, the PKC activator phorbol 12-myristate 13-acetate (PMA), but not its analog 4alpha-phorbol 12, 13-didecanoate (4alpha-PDD), suppressed TRPC6 expression, and this PMA effect was not affected by catalase.	Tetradecanoylphorbol Acetate	31-62	catalase	Rattus norvegicus	206-214
21525431-8	2011	Furthermore, the PKC activator phorbol 12-myristate 13-acetate (PMA), but not its analog 4alpha-phorbol 12, 13-didecanoate (4alpha-PDD), suppressed TRPC6 expression, and this PMA effect was not affected by catalase.	Tetradecanoylphorbol Acetate	64-67	catalase	Rattus norvegicus	206-214
21616097-9	2011	Stimulation of protein kinase C (PKC) by Phorbol-12-myristate-13-acetate (PMA) enhanced the release of PODXL to the extracellular space whereas this effect was prevented either by inhibitors of PKC or specific inhibitors of matrix metalloproteinases.	Tetradecanoylphorbol Acetate	41-72	podocalyxin like	Homo sapiens	103-108
21616097-9	2011	Stimulation of protein kinase C (PKC) by Phorbol-12-myristate-13-acetate (PMA) enhanced the release of PODXL to the extracellular space whereas this effect was prevented either by inhibitors of PKC or specific inhibitors of matrix metalloproteinases.	Tetradecanoylphorbol Acetate	74-77	podocalyxin like	Homo sapiens	103-108
21465534-5	2011	But cyclin D1-specific siRNA successfully inhibited DNA synthesis in CSE-treated or PMA-treated cells.	Tetradecanoylphorbol Acetate	84-87	cyclin D1	Rattus norvegicus	4-13
21708260-6	2011	The same phenomenon was also observed in OLs following prolonged treatment with phorbol 12 myristate 13 acetate (PMA), which downregulates the conventional and the novel PKC isoforms (cPKCs and nPKCs).	Tetradecanoylphorbol Acetate	80-111	proline rich transmembrane protein 2	Homo sapiens	170-173
21708260-6	2011	The same phenomenon was also observed in OLs following prolonged treatment with phorbol 12 myristate 13 acetate (PMA), which downregulates the conventional and the novel PKC isoforms (cPKCs and nPKCs).	Tetradecanoylphorbol Acetate	113-116	proline rich transmembrane protein 2	Homo sapiens	170-173
21659537-6	2011	Previous work indicated that mTORC1 activation by the phorbol ester PMA (phorbol 12-myristate 13-acetate) depends upon PKCs and may involve MEK.	Tetradecanoylphorbol Acetate	73-104	mitogen-activated protein kinase kinase 7	Homo sapiens	140-143
21665893-4	2011	Knockdown of endogenous PKD1 or PKD2 decreased extracellular signal-regulated kinase (ERK) 1/2 and nuclear factor-kappaB (NF-kappaB)-dependent transcriptional activities and potentiated PMA-induced apoptosis, whereas overexpression of wild-type PKD1 enhanced ERK1/2 activity and suppressed PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	186-189	polycystin 2, transient receptor potential cation channel	Homo sapiens	32-36
21665893-4	2011	Knockdown of endogenous PKD1 or PKD2 decreased extracellular signal-regulated kinase (ERK) 1/2 and nuclear factor-kappaB (NF-kappaB)-dependent transcriptional activities and potentiated PMA-induced apoptosis, whereas overexpression of wild-type PKD1 enhanced ERK1/2 activity and suppressed PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	186-189	mitogen-activated protein kinase 3	Homo sapiens	259-265
21665893-4	2011	Knockdown of endogenous PKD1 or PKD2 decreased extracellular signal-regulated kinase (ERK) 1/2 and nuclear factor-kappaB (NF-kappaB)-dependent transcriptional activities and potentiated PMA-induced apoptosis, whereas overexpression of wild-type PKD1 enhanced ERK1/2 activity and suppressed PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	290-293	polycystin 2, transient receptor potential cation channel	Homo sapiens	32-36
21665893-9	2011	In summary, our data indicate that PKD1 is activated and downregulated by PMA through a PKC-dependent ubiquitin-proteasome degradation pathway, and the activation of PKD1 or PKD2 counteracts PMA-induced apoptosis by promoting downstream ERK1/2 and NF-kappaB activities in LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	74-77	polycystin 2, transient receptor potential cation channel	Homo sapiens	174-178
21665893-9	2011	In summary, our data indicate that PKD1 is activated and downregulated by PMA through a PKC-dependent ubiquitin-proteasome degradation pathway, and the activation of PKD1 or PKD2 counteracts PMA-induced apoptosis by promoting downstream ERK1/2 and NF-kappaB activities in LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 3	Homo sapiens	237-243
21683432-3	2011	METHODS: Mitogen (concanavalin A/phorbol 12-myristate 13-acetate)-stimulated IL-4, IL-5, IL-13, and IFN-gamma levels were measured in supernatants from cord blood mononuclear cells and PBMCs at birth, 3 months, and 12 months.	Tetradecanoylphorbol Acetate	33-64	interleukin 4	Homo sapiens	77-81
21683432-3	2011	METHODS: Mitogen (concanavalin A/phorbol 12-myristate 13-acetate)-stimulated IL-4, IL-5, IL-13, and IFN-gamma levels were measured in supernatants from cord blood mononuclear cells and PBMCs at birth, 3 months, and 12 months.	Tetradecanoylphorbol Acetate	33-64	interferon gamma	Homo sapiens	100-109
21682666-7	2011	Activation of PKC with phorbol-12-myristate-13-acetate (PMA) imitated the effect of insulin and was not affected by inhibition of PI3K.	Tetradecanoylphorbol Acetate	56-59	insulin	Homo sapiens	84-91
21631112-5	2011	Similarly, in the murine ear edema model, 12-O-tetradecanoylphorbol-13-acetate-induced inflammation was inhibited by mogrosides by down-regulating COX-2 and IL-6 and up-regulating PARP1, BCL2l1, TRP53, MAPK9, and PPARdelta gene expression.	Tetradecanoylphorbol Acetate	42-78	interleukin 6	Mus musculus	157-161
21699992-1	2011	Cultured preadipocytes enhance the synthesis of prostaglandin (PG) E(2) and PGF(2alpha) involving the induction of cyclooxygenase (COX)-2 during the growth phase upon stimulation with a mixture of phorbol 12-myristate 13-acetate, a mitogenic factor, and calcium ionophore A23187.	Tetradecanoylphorbol Acetate	197-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-137
21555360-7	2011	Finally, we have shown that lipoxin A(4) can suppress phorbol myristate acetate-induced expression of the inflammatory cytokines interleukin 6 and 8 in human endometrium and decidua tissue.	Tetradecanoylphorbol Acetate	54-79	interleukin 6	Homo sapiens	129-148
21741361-5	2011	In lipopolysaccharide (LPS)-stimulated Raw 264.7 cells and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse edema model, transduced PEP-1-HO-1 fusion proteins effectively inhibited the overexpression of pro-inflammatory mediators and cytokines.	Tetradecanoylphorbol Acetate	59-95	heme oxygenase 1	Mus musculus	146-150
21631112-5	2011	Similarly, in the murine ear edema model, 12-O-tetradecanoylphorbol-13-acetate-induced inflammation was inhibited by mogrosides by down-regulating COX-2 and IL-6 and up-regulating PARP1, BCL2l1, TRP53, MAPK9, and PPARdelta gene expression.	Tetradecanoylphorbol Acetate	42-78	mitogen-activated protein kinase 9	Mus musculus	202-207
21749676-10	2011	Markers of apoptosis and PMN cell adhesion molecule expression remained unaffected by levosimendan treatment.In vivo, levosimendan treatment for two hours resulted in a significant reduction of PMA stimulated oxidative burst by 45% (P &lt; 0.01) and fMLP stimulated oxidative burst by 49% (P &lt; 0.05) in patients with acute heart failure.	Tetradecanoylphorbol Acetate	194-197	formyl peptide receptor 1	Homo sapiens	250-254
21631112-5	2011	Similarly, in the murine ear edema model, 12-O-tetradecanoylphorbol-13-acetate-induced inflammation was inhibited by mogrosides by down-regulating COX-2 and IL-6 and up-regulating PARP1, BCL2l1, TRP53, MAPK9, and PPARdelta gene expression.	Tetradecanoylphorbol Acetate	42-78	peroxisome proliferator activator receptor delta	Mus musculus	213-222
21411725-7	2011	In recombinant baby hamster kidney cells, endogenously expressing PKCepsilon but no VIP receptor, wild-type, and F508del-CFTR sensitivity to cpt-cAMP stimulation was increased by PMA treatment.	Tetradecanoylphorbol Acetate	179-182	CF transmembrane conductance regulator	Homo sapiens	121-125
21733825-2	2011	During the process of skin tumor promotion induced by treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), activation of epidermal Akt occurs as well as several downstream effectors of Akt, including the activation of mTORC1.	Tetradecanoylphorbol Acetate	125-128	thymoma viral proto-oncogene 1	Mus musculus	155-158
21733825-2	2011	During the process of skin tumor promotion induced by treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), activation of epidermal Akt occurs as well as several downstream effectors of Akt, including the activation of mTORC1.	Tetradecanoylphorbol Acetate	125-128	thymoma viral proto-oncogene 1	Mus musculus	209-212
21381080-2	2011	The stomach isoform of Cldn18, Cldn18a2 is regulated via a PKC/MAPK/AP-1-dependent pathway in PKC activator 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated gastric cancer cells.	Tetradecanoylphorbol Acetate	108-144	protein kinase C alpha	Homo sapiens	59-62
21530057-6	2011	Phorbol 12-myristate 13-acetate was used to induce the differentiation of human THP-1 monocytes into THP-1 macrophages.	Tetradecanoylphorbol Acetate	0-31	GLI family zinc finger 2	Homo sapiens	80-85
21530057-6	2011	Phorbol 12-myristate 13-acetate was used to induce the differentiation of human THP-1 monocytes into THP-1 macrophages.	Tetradecanoylphorbol Acetate	0-31	GLI family zinc finger 2	Homo sapiens	101-106
21381080-2	2011	The stomach isoform of Cldn18, Cldn18a2 is regulated via a PKC/MAPK/AP-1-dependent pathway in PKC activator 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated gastric cancer cells.	Tetradecanoylphorbol Acetate	108-144	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-72
21381080-2	2011	The stomach isoform of Cldn18, Cldn18a2 is regulated via a PKC/MAPK/AP-1-dependent pathway in PKC activator 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated gastric cancer cells.	Tetradecanoylphorbol Acetate	146-149	protein kinase C alpha	Homo sapiens	59-62
21381080-2	2011	The stomach isoform of Cldn18, Cldn18a2 is regulated via a PKC/MAPK/AP-1-dependent pathway in PKC activator 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated gastric cancer cells.	Tetradecanoylphorbol Acetate	146-149	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-72
21381080-6	2011	The upregulation of Cldn18 by TPA in human pancreatic cancer cell lines was prevented by inhibitors of PKCdelta, PKCepsilon, and PKCalpha, whereas the upregulation of Cldn18 by TPA in hTERT-HPDE cells was prevented by inhibitors of PKCdelta, PKCtheta, and PKCalpha.	Tetradecanoylphorbol Acetate	30-33	protein kinase C alpha	Homo sapiens	129-137
21381080-6	2011	The upregulation of Cldn18 by TPA in human pancreatic cancer cell lines was prevented by inhibitors of PKCdelta, PKCepsilon, and PKCalpha, whereas the upregulation of Cldn18 by TPA in hTERT-HPDE cells was prevented by inhibitors of PKCdelta, PKCtheta, and PKCalpha.	Tetradecanoylphorbol Acetate	30-33	protein kinase C alpha	Homo sapiens	256-264
21246637-0	2011	Evodiamine inhibits 12-O-tetradecanoylphorbol-13-acetate-induced activator protein 1 transactivation and cell transformation in human hepatocytes.	Tetradecanoylphorbol Acetate	20-56	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-84
21045076-10	2011	Inhibition of SOD2 reduced the PMA-induced respiratory burst and IL1A, IL-1R1, IL-1R2 and IL8RA gene expression in neutrophil-differentiated HL60 cells.	Tetradecanoylphorbol Acetate	31-34	interleukin 1 receptor type 1	Homo sapiens	71-77
21684020-3	2011	Conditioned medium from the LPS-stimulated TPA-HL-60 cells increased MOR expression in SH-SY5Y cells, a neuronal cell model, through actions mediated by TNF-alpha and GM-CSF.	Tetradecanoylphorbol Acetate	43-46	tumor necrosis factor	Homo sapiens	153-162
21246637-5	2011	The Chang/AP-1 cells were treated with E. rutaecarpa and its bioactive constituents, and challenged with the AP-1 stimulator 12-O-tetradecanoylphorbol-13- acetate (TPA).	Tetradecanoylphorbol Acetate	125-162	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	109-113
21246637-6	2011	The present study showed that the methanol extract of E. rutaecarpa decreased the TPA-induced AP-1 transactivation in Chang/AP-1 cells, with an EC50 value of 24.72 mug/mL.	Tetradecanoylphorbol Acetate	82-85	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	94-98
21246637-6	2011	The present study showed that the methanol extract of E. rutaecarpa decreased the TPA-induced AP-1 transactivation in Chang/AP-1 cells, with an EC50 value of 24.72 mug/mL.	Tetradecanoylphorbol Acetate	82-85	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	124-128
21246637-7	2011	EVO inhibited the TPA-induced AP-1 transactivation and colony formation, with EC50 values of 82 muM and 8.2 muM, respectively.	Tetradecanoylphorbol Acetate	18-21	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-34
21246637-9	2011	These results suggested that EVO treatment suppressed the TPA-induced AP-1 activity via the ERKs pathway.	Tetradecanoylphorbol Acetate	58-61	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	70-74
21460222-7	2011	It resulted in up-regulation of the transcription factor c-Jun and the activation marker CD69 as well as enhanced production of IL-2 after phorbol 12-myristate 13-acetate (PMA) and ionomycin treatment.	Tetradecanoylphorbol Acetate	139-170	interleukin 2	Homo sapiens	128-132
21392518-5	2011	Chromatin immunoprecipitation demonstrated endogenous LRH-1 occupancy on PII under basal conditions and with treatment with forskolin and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	138-169	nuclear receptor subfamily 5 group A member 2	Homo sapiens	54-59
21392518-5	2011	Chromatin immunoprecipitation demonstrated endogenous LRH-1 occupancy on PII under basal conditions and with treatment with forskolin and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	171-174	nuclear receptor subfamily 5 group A member 2	Homo sapiens	54-59
21670270-3	2011	Recently the hair follicle stem cell marker CD34 was used to purify a CSC-like cell population from early skin tumors arising from treatment with 7,12-dimethylbenz[alpha]anthracene/12-o-tetradecanoylphorbol-13-acetate, which typically generates benign papillomas that occasionally progress to squamous cell carcinomas (SCCs).	Tetradecanoylphorbol Acetate	181-217	CD34 molecule	Homo sapiens	44-48
21460222-7	2011	It resulted in up-regulation of the transcription factor c-Jun and the activation marker CD69 as well as enhanced production of IL-2 after phorbol 12-myristate 13-acetate (PMA) and ionomycin treatment.	Tetradecanoylphorbol Acetate	172-175	interleukin 2	Homo sapiens	128-132
21557328-6	2011	TPA alone induced transactivation of the EGFR but did not induce ERK oscillations.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor receptor	Homo sapiens	41-45
21268127-3	2011	EP1 mRNA levels were increased ~2-fold after topical treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) or exposure to ultraviolet (UV) light, as well as increased ~3- to 12-fold in tumors induced by 7,12-dimethyl-benz[a]anthracene (DMBA) initiation/TPA promotion or by UV exposure.	Tetradecanoylphorbol Acetate	68-104	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	0-3
21268127-3	2011	EP1 mRNA levels were increased ~2-fold after topical treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) or exposure to ultraviolet (UV) light, as well as increased ~3- to 12-fold in tumors induced by 7,12-dimethyl-benz[a]anthracene (DMBA) initiation/TPA promotion or by UV exposure.	Tetradecanoylphorbol Acetate	106-109	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	0-3
21268127-3	2011	EP1 mRNA levels were increased ~2-fold after topical treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) or exposure to ultraviolet (UV) light, as well as increased ~3- to 12-fold in tumors induced by 7,12-dimethyl-benz[a]anthracene (DMBA) initiation/TPA promotion or by UV exposure.	Tetradecanoylphorbol Acetate	257-260	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	0-3
21268127-6	2011	Using a DMBA/TPA carcinogenesis protocol, BK5.EP1 mice had a reduced tumor multiplicity compared to WT mice, likely due to the observed down-regulation of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	13-16	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	46-49
21042803-8	2011	Western blot analyses revealed that EC and EGCG prevented down-regulation of Cx26 and Cx43 proteins in HaCaT cells treated with PMA.	Tetradecanoylphorbol Acetate	128-131	gap junction protein beta 2	Homo sapiens	77-81
21042803-9	2011	Immunocytochemistry showed decreased expression and abnormal location of Cx26 and Cx43 in HaCaT cells when treated with PMA, and EC and EGCG inhibited its effect.	Tetradecanoylphorbol Acetate	120-123	gap junction protein beta 2	Homo sapiens	73-77
21557328-7	2011	TPA as a cotreatment did not inhibit TGFalpha-stimulated ERK oscillations but qualitatively altered TGFalpha-dependent ERK oscillation characteristics (amplitude, time-period).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	119-122
21354279-7	2011	Furthermore, piperine strongly repressed the PMA-induced phosphorylation of ERK, which are dependent on the PKCalpha pathway.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase 1	Homo sapiens	76-79
21527758-1	2011	BACKGROUND AND PURPOSE: Intravenous tissue-type plasminogen activator (IV tPA) frequently fails to recanalize proximal middle cerebral artery (MCA-M1) obstructions, preventing favorable outcomes.	Tetradecanoylphorbol Acetate	74-77	plasminogen activator, tissue type	Homo sapiens	36-69
21354279-0	2011	Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCalpha/ERK1/2-dependent matrix metalloproteinase-9 expression.	Tetradecanoylphorbol Acetate	15-46	protein kinase C alpha	Homo sapiens	109-117
21354279-0	2011	Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCalpha/ERK1/2-dependent matrix metalloproteinase-9 expression.	Tetradecanoylphorbol Acetate	15-46	mitogen-activated protein kinase 3	Homo sapiens	118-124
21354279-4	2011	We found that piperine suppresses PMA-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB and AP-1 activation without changing the level of tissue inhibitor of metalloproteinase (TIMP)-1.	Tetradecanoylphorbol Acetate	34-37	TIMP metallopeptidase inhibitor 1	Homo sapiens	229-275
21354279-7	2011	Furthermore, piperine strongly repressed the PMA-induced phosphorylation of ERK, which are dependent on the PKCalpha pathway.	Tetradecanoylphorbol Acetate	45-48	protein kinase C alpha	Homo sapiens	108-116
21217772-5	2011	In Jurkat leukaemic T cells as well as in primary human T cells, tetradecanoylphorbolacetate/ionomycin- and CD3/CD28-induced RelB degradation were impaired by a GSK-3beta-specific pharmacological inhibitor, an ectopically expressed dominant-negative GSK-3beta mutant and by small-interfering RNA-mediated silencing of GSK-3beta expression.	Tetradecanoylphorbol Acetate	65-92	RELB proto-oncogene, NF-kB subunit	Homo sapiens	125-129
21539301-5	2011	Compounds 1-8 were found to rescue Pdcd4 from TPA-induced degradation with EC50 concentrations that ranged from 1.3 to 4.9 muM.	Tetradecanoylphorbol Acetate	46-49	latexin	Homo sapiens	123-126
21901168-5	2011	PMA induces the dissociation, which leads to relocation of MEK1 to lipid rafts and WOX1 to the mitochondria for causing apoptosis.	Tetradecanoylphorbol Acetate	0-3	WW domain containing oxidoreductase	Homo sapiens	83-87
21376359-3	2011	After treatment with chemical inducers, including sodium butyrate (SB) and TPA, the levels of YY1 protein are inversely correlated with the lytic induction of KSHV in cells.	Tetradecanoylphorbol Acetate	75-78	YY1 transcription factor	Homo sapiens	94-97
21376359-4	2011	Overexpression of YY1 completely blocks the ORF50p activation in transient reporter assays, while mutation at the YY1 site in the ORF50p or knockdown of YY1 protein confers an enhancement of the ORF50p activation induced by SB and TPA.	Tetradecanoylphorbol Acetate	231-234	YY1 transcription factor	Homo sapiens	18-21
21376359-4	2011	Overexpression of YY1 completely blocks the ORF50p activation in transient reporter assays, while mutation at the YY1 site in the ORF50p or knockdown of YY1 protein confers an enhancement of the ORF50p activation induced by SB and TPA.	Tetradecanoylphorbol Acetate	231-234	YY1 transcription factor	Homo sapiens	114-117
21376359-4	2011	Overexpression of YY1 completely blocks the ORF50p activation in transient reporter assays, while mutation at the YY1 site in the ORF50p or knockdown of YY1 protein confers an enhancement of the ORF50p activation induced by SB and TPA.	Tetradecanoylphorbol Acetate	231-234	YY1 transcription factor	Homo sapiens	114-117
21542090-2	2011	In LNCaP human prostate cancer cells, PMA induces tumor necrosis factor alpha (TNFalpha) secretion and inhibits proliferation; bryostatin 1 does not, and indeed blocks the response to PMA.	Tetradecanoylphorbol Acetate	38-41	tumor necrosis factor	Homo sapiens	50-77
21542090-2	2011	In LNCaP human prostate cancer cells, PMA induces tumor necrosis factor alpha (TNFalpha) secretion and inhibits proliferation; bryostatin 1 does not, and indeed blocks the response to PMA.	Tetradecanoylphorbol Acetate	38-41	tumor necrosis factor	Homo sapiens	79-87
21336470-9	2011	Although the p38alpha isoform is important, our data also demonstrate an important role of the p38beta and/or delta isoforms in the regulation of TPA-induced skin inflammation.	Tetradecanoylphorbol Acetate	146-149	mitogen-activated protein kinase 11	Mus musculus	95-102
21191110-7	2011	Also, supplementation with phorbol 12-myristate 13-acetate (PMA) stimulated IFNT mRNA levels to the same extent as with FGF2.	Tetradecanoylphorbol Acetate	27-58	fibroblast growth factor 2	Bos taurus	120-124
21191110-7	2011	Also, supplementation with phorbol 12-myristate 13-acetate (PMA) stimulated IFNT mRNA levels to the same extent as with FGF2.	Tetradecanoylphorbol Acetate	60-63	fibroblast growth factor 2	Bos taurus	120-124
21536764-2	2011	Successful transfection of THP-1 monocytes with subsequent phorbol 12-myristate 13-acetate (PMA)-induced differentiation into macrophages is not a trivial matter, because according to previous transfection protocols, cell viability is lost almost completely within 24 h of PMA treatment following transfection.	Tetradecanoylphorbol Acetate	59-90	GLI family zinc finger 2	Homo sapiens	27-32
21536764-2	2011	Successful transfection of THP-1 monocytes with subsequent phorbol 12-myristate 13-acetate (PMA)-induced differentiation into macrophages is not a trivial matter, because according to previous transfection protocols, cell viability is lost almost completely within 24 h of PMA treatment following transfection.	Tetradecanoylphorbol Acetate	92-95	GLI family zinc finger 2	Homo sapiens	27-32
21901168-6	2011	U0126 inhibits PMA-induced dissociation of WOX1/MEK1 complex and supports survival of Jurkat cells.	Tetradecanoylphorbol Acetate	15-18	WW domain containing oxidoreductase	Homo sapiens	43-47
21499124-6	2011	Binding activity to ULBP1 promoter region of AP-2alpha, which suggested as suppressor of expression of ULBP1, was decreased by treatment with EGFR inhibitors, and restored by pretreatment with phorbol 12-myristate 13-acetate in A549 and SW-900.	Tetradecanoylphorbol Acetate	193-224	epidermal growth factor receptor	Homo sapiens	142-146
20979021-3	2011	The MeOH extract inhibited the production of phorbol-12-myristate-13-acetate-induced inflammatory cytokines such as tumor necrosis factor (TNF)-alpha in cultured THP-1 cells, and also restrained the intracellular synthesis of melanin in murine melanoma B16F1 cells.	Tetradecanoylphorbol Acetate	45-76	tumor necrosis factor	Homo sapiens	116-149
21089054-0	2011	Acteoside inhibits PMA-induced matrix metalloproteinase-9 expression via CaMK/ERK- and JNK/NF-kappaB-dependent signaling.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase 1	Homo sapiens	78-81
21089054-0	2011	Acteoside inhibits PMA-induced matrix metalloproteinase-9 expression via CaMK/ERK- and JNK/NF-kappaB-dependent signaling.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase 8	Homo sapiens	87-90
21089054-0	2011	Acteoside inhibits PMA-induced matrix metalloproteinase-9 expression via CaMK/ERK- and JNK/NF-kappaB-dependent signaling.	Tetradecanoylphorbol Acetate	19-22	nuclear factor kappa B subunit 1	Homo sapiens	91-100
21089054-5	2011	We found that acteoside suppresses phorbol-12-myristate-13-acetate (PMA)-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB activation.	Tetradecanoylphorbol Acetate	35-66	nuclear factor kappa B subunit 1	Homo sapiens	204-213
21499124-5	2011	Treatment with phorbol 12-myristate 13-acetate restored the EGFR inhibitor-induced ULBP1 transcription.	Tetradecanoylphorbol Acetate	15-46	epidermal growth factor receptor	Homo sapiens	60-64
21089054-5	2011	We found that acteoside suppresses phorbol-12-myristate-13-acetate (PMA)-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB activation.	Tetradecanoylphorbol Acetate	68-71	nuclear factor kappa B subunit 1	Homo sapiens	204-213
21089054-6	2011	In addition, acteoside repressed the PMA-induced phosphorylation of ERK1/2 (ERK, extracellular regulated kinase) and JNK1/2.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 1	Homo sapiens	68-74
21089054-6	2011	In addition, acteoside repressed the PMA-induced phosphorylation of ERK1/2 (ERK, extracellular regulated kinase) and JNK1/2.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 1	Homo sapiens	68-71
21089054-6	2011	In addition, acteoside repressed the PMA-induced phosphorylation of ERK1/2 (ERK, extracellular regulated kinase) and JNK1/2.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 8	Homo sapiens	117-123
21089054-9	2011	CONCLUSION: Acteoside inhibited PMA-induced invasion and migration of human fibrosarcoma cells via Ca(2+) -dependent CaMK/ERK and JNK/NF-kappaB-signaling pathways.	Tetradecanoylphorbol Acetate	32-35	mitogen-activated protein kinase 1	Homo sapiens	122-125
21089054-9	2011	CONCLUSION: Acteoside inhibited PMA-induced invasion and migration of human fibrosarcoma cells via Ca(2+) -dependent CaMK/ERK and JNK/NF-kappaB-signaling pathways.	Tetradecanoylphorbol Acetate	32-35	mitogen-activated protein kinase 8	Homo sapiens	130-133
21089054-9	2011	CONCLUSION: Acteoside inhibited PMA-induced invasion and migration of human fibrosarcoma cells via Ca(2+) -dependent CaMK/ERK and JNK/NF-kappaB-signaling pathways.	Tetradecanoylphorbol Acetate	32-35	nuclear factor kappa B subunit 1	Homo sapiens	134-143
21323644-4	2011	The importance of ERK with respect to downstream NF-kappaB signalling was underscored by the finding that PMA, a potent ERK activator, enhanced IKK phosphorylation.	Tetradecanoylphorbol Acetate	106-109	Eph receptor B1	Rattus norvegicus	18-21
21415399-1	2011	BACKGROUND AND PURPOSE: Stroke magnetic resonance imaging with perfusion and diffusion weighting has shown its potential to select patients likely to benefit from intravenous thrombolysis with tissue-type plasminogen activator (IV-tPA).	Tetradecanoylphorbol Acetate	231-234	plasminogen activator, tissue type	Homo sapiens	193-226
21323644-4	2011	The importance of ERK with respect to downstream NF-kappaB signalling was underscored by the finding that PMA, a potent ERK activator, enhanced IKK phosphorylation.	Tetradecanoylphorbol Acetate	106-109	Eph receptor B1	Rattus norvegicus	120-123
21323644-5	2011	Strikingly, both palmitate- and PMA-induced activation of IKK/NF-kappaB were antagonized by AMPK (AMP-activated protein kinase) activators because of reduced ERK signalling.	Tetradecanoylphorbol Acetate	32-35	Eph receptor B1	Rattus norvegicus	158-161
21300803-3	2011	In this study, we used HL-60 cells as a model to investigate the regulatory elements/factors involved in the transactivation of the SLC11A1 gene during phorbol 12-myristate 13-acetate (PMA)-induced macrophage differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	152-183	solute carrier family 11 member 1	Homo sapiens	132-139
21300803-3	2011	In this study, we used HL-60 cells as a model to investigate the regulatory elements/factors involved in the transactivation of the SLC11A1 gene during phorbol 12-myristate 13-acetate (PMA)-induced macrophage differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	185-188	solute carrier family 11 member 1	Homo sapiens	132-139
21300803-8	2011	Furthermore, we showed that PMA can induce the proximal (GT/AC)(n) repeat sequence to convert to the Z-DNA structure in the SLC11A1 gene promoter, and depletion of BRG1 resulted in a significant decrease of Z-DNA formation.	Tetradecanoylphorbol Acetate	28-31	solute carrier family 11 member 1	Homo sapiens	124-131
21212180-12	2011	PMA-stimulated ERK activity was also inhibited by 1-butanol.	Tetradecanoylphorbol Acetate	0-3	Eph receptor B1	Rattus norvegicus	15-18
21372127-9	2011	Our data showed that phorbol 12-myristate 13-acetate-induced differentiation of macrophages is accompanied by a robust induction of apoE and STAT1 expression.	Tetradecanoylphorbol Acetate	21-52	apolipoprotein E	Homo sapiens	132-136
21295103-5	2011	The mechanism revealed that wogonin significantly inhibited the expression and activity of both endogenous and phorbol-12-myristate-13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) potentially associating with the suppression of translocation of protein kinase C (PKC) delta and phosphorylation of extracellular signal-regulated kinase (ERK1/2).	Tetradecanoylphorbol Acetate	111-142	mitogen-activated protein kinase 3	Homo sapiens	348-354
21295103-5	2011	The mechanism revealed that wogonin significantly inhibited the expression and activity of both endogenous and phorbol-12-myristate-13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) potentially associating with the suppression of translocation of protein kinase C (PKC) delta and phosphorylation of extracellular signal-regulated kinase (ERK1/2).	Tetradecanoylphorbol Acetate	144-147	mitogen-activated protein kinase 3	Homo sapiens	348-354
21297032-11	2011	These results suggest that the MEK/ERK1/2 pathway is necessary but not sufficient to regulate the PMA-dependent activation of Nox5.	Tetradecanoylphorbol Acetate	98-101	mitogen-activated protein kinase 3	Homo sapiens	35-41
21256190-7	2011	RESULTS: Hypertonic sucrose and NaCl significantly enhanced TNF-alpha release from THP-1 cells upon LPS or PMA stimulation.	Tetradecanoylphorbol Acetate	107-110	tumor necrosis factor	Homo sapiens	60-69
21297032-11	2011	These results suggest that the MEK/ERK1/2 pathway is necessary but not sufficient to regulate the PMA-dependent activation of Nox5.	Tetradecanoylphorbol Acetate	98-101	mitogen-activated protein kinase kinase 7	Homo sapiens	31-34
21216846-4	2011	p-HPEA-EDA inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation of extracellular signal-regulated kinases 1/2 and p90RSK in JB6 Cl41 cells, resulting in the inhibition of cell proliferation, activator protein-1 transactivation and cell transformation promoted by TPA.	Tetradecanoylphorbol Acetate	59-62	mitogen-activated protein kinase 3	Homo sapiens	91-133
20521099-6	2011	PA was found to bring about a reduction in phorbol 12-myristate 13-acetate (PMA)-induced transcriptional activity of NF-kappaB, but not that of AP-1.	Tetradecanoylphorbol Acetate	43-74	nuclear factor kappa B subunit 1	Homo sapiens	117-126
20521099-6	2011	PA was found to bring about a reduction in phorbol 12-myristate 13-acetate (PMA)-induced transcriptional activity of NF-kappaB, but not that of AP-1.	Tetradecanoylphorbol Acetate	76-79	nuclear factor kappa B subunit 1	Homo sapiens	117-126
21216846-4	2011	p-HPEA-EDA inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation of extracellular signal-regulated kinases 1/2 and p90RSK in JB6 Cl41 cells, resulting in the inhibition of cell proliferation, activator protein-1 transactivation and cell transformation promoted by TPA.	Tetradecanoylphorbol Acetate	287-290	mitogen-activated protein kinase 3	Homo sapiens	91-133
21216846-4	2011	p-HPEA-EDA inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation of extracellular signal-regulated kinases 1/2 and p90RSK in JB6 Cl41 cells, resulting in the inhibition of cell proliferation, activator protein-1 transactivation and cell transformation promoted by TPA.	Tetradecanoylphorbol Acetate	21-57	mitogen-activated protein kinase 3	Homo sapiens	91-133
21223991-9	2011	We also found that gossypol suppresses NF-kappaB activation induced by a wide variety of agents, including taxol, okadaic acid, and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	132-157	nuclear factor kappa B subunit 1	Homo sapiens	39-48
21303260-3	2011	Topical application of 5 nmol of TPA to mouse ears markedly increased the ear weight, expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein, and phosphorylation of the inhibitor of kappaB (IkappaB) alpha, AKT, and extracellular signal-regulated protein kinase (ERK) 1/2 and reduced IkappaBalpha protein levels.	Tetradecanoylphorbol Acetate	33-36	nitric oxide synthase 2, inducible	Mus musculus	104-135
21303260-3	2011	Topical application of 5 nmol of TPA to mouse ears markedly increased the ear weight, expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein, and phosphorylation of the inhibitor of kappaB (IkappaB) alpha, AKT, and extracellular signal-regulated protein kinase (ERK) 1/2 and reduced IkappaBalpha protein levels.	Tetradecanoylphorbol Acetate	33-36	nitric oxide synthase 2, inducible	Mus musculus	137-141
21303260-3	2011	Topical application of 5 nmol of TPA to mouse ears markedly increased the ear weight, expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein, and phosphorylation of the inhibitor of kappaB (IkappaB) alpha, AKT, and extracellular signal-regulated protein kinase (ERK) 1/2 and reduced IkappaBalpha protein levels.	Tetradecanoylphorbol Acetate	33-36	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	216-241
21303260-3	2011	Topical application of 5 nmol of TPA to mouse ears markedly increased the ear weight, expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein, and phosphorylation of the inhibitor of kappaB (IkappaB) alpha, AKT, and extracellular signal-regulated protein kinase (ERK) 1/2 and reduced IkappaBalpha protein levels.	Tetradecanoylphorbol Acetate	33-36	thymoma viral proto-oncogene 1	Mus musculus	243-246
21303260-3	2011	Topical application of 5 nmol of TPA to mouse ears markedly increased the ear weight, expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein, and phosphorylation of the inhibitor of kappaB (IkappaB) alpha, AKT, and extracellular signal-regulated protein kinase (ERK) 1/2 and reduced IkappaBalpha protein levels.	Tetradecanoylphorbol Acetate	33-36	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	320-332
21192914-5	2011	Phorbol ester (PMA) activates MGF synthesis in human myoblasts and myotubes only.	Tetradecanoylphorbol Acetate	15-18	insulin like growth factor 1	Homo sapiens	30-33
21192914-7	2011	Stimulation of MGF expression in human cells by db-cAMP and PMA demonstrated different time dependences but showed additivity when the compounds were applied in a combination.	Tetradecanoylphorbol Acetate	60-63	insulin like growth factor 1	Homo sapiens	15-18
21205932-10	2011	We also demonstrated that insulin localizes phosphorylated Akt to lipid microdomains and that PMA reduces phosphorylated Akt.	Tetradecanoylphorbol Acetate	94-97	AKT serine/threonine kinase 1	Homo sapiens	121-124
21324306-5	2011	In a mouse edema model, PEP-1-catalase inhibited the increased expressions of inflammatory mediators and cytokines such as cyclooxygenase-2, inducible nitric oxide synthase, interleukin-6 and -1beta, and tumor necrosis factor-alpha induced by TPA.	Tetradecanoylphorbol Acetate	243-246	tumor necrosis factor	Mus musculus	174-231
21177779-10	2011	Downregulation of protein kinase C (PKC) using phorbol 12-myristate 13-acetate, or PKC inhibition with calphostin C, markedly reduced flow-stimulated ET-1 mRNA levels.	Tetradecanoylphorbol Acetate	47-78	endothelin 1	Rattus norvegicus	150-154
21135065-10	2011	Furthermore, CASR(T888M) elicited sustained Ca(2+)(i) mobilization rather than high frequency Ca(2+)(i) oscillations, and, unlike the wt-CASR, the response was resistant to acute inhibition by the PKC activator, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	212-243	calcium sensing receptor	Homo sapiens	13-17
21133891-4	2011	EXPERIMENTAL APPROACH: COS-7 cells in which OATP1A2 was overexpressed were treated with the PKC-specific activator (phorbol 12-myristate 13-acetate; PMA) and the PKC-specific inhibitor (Go6976).	Tetradecanoylphorbol Acetate	149-152	proline rich transmembrane protein 2	Homo sapiens	92-95
21133891-7	2011	PMA (0.1 microM) decreased the V(max) of oestrone-3-sulphate uptake and decreased the cell surface expression of OATP1A2 immunoreactive protein; these effects of PMA were prevented by the PKC specific inhibitor Go6976.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	188-191
21133891-7	2011	PMA (0.1 microM) decreased the V(max) of oestrone-3-sulphate uptake and decreased the cell surface expression of OATP1A2 immunoreactive protein; these effects of PMA were prevented by the PKC specific inhibitor Go6976.	Tetradecanoylphorbol Acetate	162-165	proline rich transmembrane protein 2	Homo sapiens	188-191
20604677-4	2011	The results indicated that beta-eudesmol inhibited the production and expression of interleukin (IL)-6 on phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cell (HMC).	Tetradecanoylphorbol Acetate	106-137	interleukin 6	Homo sapiens	84-102
21262201-5	2011	DHAvD also suppressed activation of mitogen-activated protein kinase (MAPK), and MAPK-mediated nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) activations in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	176-179	nuclear factor kappa B subunit 1	Homo sapiens	95-117
20158570-5	2011	Using 1-butanol, a PLD substrate, to block phosphatidic acid (PA) generation, the PMA-stimulated neutrophil respiratory burst was also partially inhibited, further indicating that PLD activation, possibly its hydrolytic product PA and diacylglycerol (DAG), is involved in PMA-stimulated respiratory burst.	Tetradecanoylphorbol Acetate	82-85	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	180-183
20158570-5	2011	Using 1-butanol, a PLD substrate, to block phosphatidic acid (PA) generation, the PMA-stimulated neutrophil respiratory burst was also partially inhibited, further indicating that PLD activation, possibly its hydrolytic product PA and diacylglycerol (DAG), is involved in PMA-stimulated respiratory burst.	Tetradecanoylphorbol Acetate	272-275	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	180-183
20158570-7	2011	To further study whether PLD contributes to the PMA stimulated respiratory burst through itself or its hydrolytic product, 1,2-dioctanoyl-sn-glycerol, an analogue of DAG , was used to prime cells at low concentration, and it reversed the inhibition of PMA-stimulated respiratory burst by U73122.	Tetradecanoylphorbol Acetate	48-51	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	25-28
20158570-8	2011	The results indicate that U73122 may act as an inhibitor of PLD, and PLD activation is required in PMA-stimulated respiratory burst.	Tetradecanoylphorbol Acetate	99-102	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	69-72
20158570-2	2011	However, the PLD activity was also increased by 10-fold in human neutrophils stimulated with 100 nM PMA.	Tetradecanoylphorbol Acetate	100-103	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	13-16
20158570-5	2011	Using 1-butanol, a PLD substrate, to block phosphatidic acid (PA) generation, the PMA-stimulated neutrophil respiratory burst was also partially inhibited, further indicating that PLD activation, possibly its hydrolytic product PA and diacylglycerol (DAG), is involved in PMA-stimulated respiratory burst.	Tetradecanoylphorbol Acetate	82-85	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	19-22
21159825-6	2011	RESULTS: CD101 expression coincided with PMA-induced monocyte/leukocyte lineage differentiation.	Tetradecanoylphorbol Acetate	41-44	CD101 molecule	Homo sapiens	9-14
20734334-7	2011	Topical application of DMBA/TPA to the skin resulted in well-developed carcinomas associated with decreased expression of pro-apoptotic protein such as caspase 3 and enhanced expression of antiapoptotic protein such as bcl-2 when compared with the control counterparts.	Tetradecanoylphorbol Acetate	28-31	B cell leukemia/lymphoma 2	Mus musculus	219-224
21262201-5	2011	DHAvD also suppressed activation of mitogen-activated protein kinase (MAPK), and MAPK-mediated nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) activations in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	176-179	nuclear factor kappa B subunit 1	Homo sapiens	119-128
21262201-5	2011	DHAvD also suppressed activation of mitogen-activated protein kinase (MAPK), and MAPK-mediated nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) activations in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	176-179	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-153
21262201-5	2011	DHAvD also suppressed activation of mitogen-activated protein kinase (MAPK), and MAPK-mediated nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) activations in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	176-179	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	155-159
21262201-6	2011	The results indicate that DHAvD-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the MAPK/NF-kappaB and MAPK/AP-1 pathways in MCF-7 cells.	Tetradecanoylphorbol Acetate	55-58	nuclear factor kappa B subunit 1	Homo sapiens	139-148
21262201-6	2011	The results indicate that DHAvD-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the MAPK/NF-kappaB and MAPK/AP-1 pathways in MCF-7 cells.	Tetradecanoylphorbol Acetate	55-58	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	158-162
21302967-3	2011	This sesquiterpenoid inhibited the secretion and expression of IL-6 in phorbol 12-myristate 13-acetate- and calcium ionophore A23187-stimulated human mast cells (HMC)-1.	Tetradecanoylphorbol Acetate	71-102	interleukin 6	Homo sapiens	63-67
21173077-2	2011	We have shown that retinoic acid (RA), which is known to play a necessary role in early events in pregnancy, can combine with transcriptional activators of VEGF (e.g. TPA, TGF-beta, IL-1beta) to rapidly induce VEGF secretion from human endometrial stromal cells through a translational mechanism of action.	Tetradecanoylphorbol Acetate	167-170	vascular endothelial growth factor A	Homo sapiens	156-160
21173077-5	2011	Importantly, co-treatment of RA with TPA or TGF-beta further stimulated ROS production in a fashion that positively correlated with levels of VEGF secretion.	Tetradecanoylphorbol Acetate	37-40	vascular endothelial growth factor A	Homo sapiens	142-146
21541047-7	2011	Among the five compounds tested, MK-2 caused the greatest reduction in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced acute inflammation in mouse ear.	Tetradecanoylphorbol Acetate	71-107	MAP kinase-activated protein kinase 2	Mus musculus	33-37
21541047-7	2011	Among the five compounds tested, MK-2 caused the greatest reduction in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced acute inflammation in mouse ear.	Tetradecanoylphorbol Acetate	109-112	MAP kinase-activated protein kinase 2	Mus musculus	33-37
20669245-5	2011	Using a cell model for inflammatory response, we showed that TF-2 suppressed the 12-O-tetradecanoylphorbol-13-acetate-induced COX-2 gene expression, and also down-regulated TNF-alpha, iNOS, ICAM-1, and NFkappaB.	Tetradecanoylphorbol Acetate	81-117	prostaglandin-endoperoxide synthase 2	Homo sapiens	126-131
21062642-2	2011	In HEK293 and Jurkat cells, the Ca2(+) release and Ca2(+) uptake stimulated by several different activators were attenuated by activation of PKC with phorbol myristate acetate (PMA) or 1-oleoyl-2-acetyl-sn-glycerol (OAG) and potentiated by PKC inhibition with Go6983 or knockdown of PKCalpha or PKCbeta using shRNA.	Tetradecanoylphorbol Acetate	150-175	protein kinase C alpha	Homo sapiens	141-144
21062642-2	2011	In HEK293 and Jurkat cells, the Ca2(+) release and Ca2(+) uptake stimulated by several different activators were attenuated by activation of PKC with phorbol myristate acetate (PMA) or 1-oleoyl-2-acetyl-sn-glycerol (OAG) and potentiated by PKC inhibition with Go6983 or knockdown of PKCalpha or PKCbeta using shRNA.	Tetradecanoylphorbol Acetate	150-175	protein kinase C alpha	Homo sapiens	240-243
21062642-2	2011	In HEK293 and Jurkat cells, the Ca2(+) release and Ca2(+) uptake stimulated by several different activators were attenuated by activation of PKC with phorbol myristate acetate (PMA) or 1-oleoyl-2-acetyl-sn-glycerol (OAG) and potentiated by PKC inhibition with Go6983 or knockdown of PKCalpha or PKCbeta using shRNA.	Tetradecanoylphorbol Acetate	150-175	protein kinase C alpha	Homo sapiens	283-291
21062642-2	2011	In HEK293 and Jurkat cells, the Ca2(+) release and Ca2(+) uptake stimulated by several different activators were attenuated by activation of PKC with phorbol myristate acetate (PMA) or 1-oleoyl-2-acetyl-sn-glycerol (OAG) and potentiated by PKC inhibition with Go6983 or knockdown of PKCalpha or PKCbeta using shRNA.	Tetradecanoylphorbol Acetate	177-180	protein kinase C alpha	Homo sapiens	141-144
21062642-2	2011	In HEK293 and Jurkat cells, the Ca2(+) release and Ca2(+) uptake stimulated by several different activators were attenuated by activation of PKC with phorbol myristate acetate (PMA) or 1-oleoyl-2-acetyl-sn-glycerol (OAG) and potentiated by PKC inhibition with Go6983 or knockdown of PKCalpha or PKCbeta using shRNA.	Tetradecanoylphorbol Acetate	177-180	protein kinase C alpha	Homo sapiens	240-243
21062642-2	2011	In HEK293 and Jurkat cells, the Ca2(+) release and Ca2(+) uptake stimulated by several different activators were attenuated by activation of PKC with phorbol myristate acetate (PMA) or 1-oleoyl-2-acetyl-sn-glycerol (OAG) and potentiated by PKC inhibition with Go6983 or knockdown of PKCalpha or PKCbeta using shRNA.	Tetradecanoylphorbol Acetate	177-180	protein kinase C alpha	Homo sapiens	283-291
21165548-3	2011	In the present study, we demonstrate that artemisinin inhibits the secretion and the mRNA levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1ss, and IL-6 in a dose-dependent manner in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 human monocytes.	Tetradecanoylphorbol Acetate	196-227	tumor necrosis factor	Homo sapiens	100-133
21165548-3	2011	In the present study, we demonstrate that artemisinin inhibits the secretion and the mRNA levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1ss, and IL-6 in a dose-dependent manner in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 human monocytes.	Tetradecanoylphorbol Acetate	196-227	interleukin 6	Homo sapiens	161-165
21165548-3	2011	In the present study, we demonstrate that artemisinin inhibits the secretion and the mRNA levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1ss, and IL-6 in a dose-dependent manner in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 human monocytes.	Tetradecanoylphorbol Acetate	229-232	tumor necrosis factor	Homo sapiens	100-133
21134074-10	2011	The HUVEC co-cultured with TAM (PMA-treated THP-1 macrophages co-cultured with GC cells) expressed high levels of FXIIa.	Tetradecanoylphorbol Acetate	32-35	GLI family zinc finger 2	Homo sapiens	44-49
20422426-4	2011	METHODS: The cytotoxicity of COX-2 inducer (TPA, tetradecanoyl phorbol acetate) and its inhibitor (celecoxib) was determined by an MTT assay.	Tetradecanoylphorbol Acetate	49-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	29-34
20953574-5	2011	Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1.	Tetradecanoylphorbol Acetate	95-126	nuclear factor kappa B subunit 1	Homo sapiens	209-218
20953574-5	2011	Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1.	Tetradecanoylphorbol Acetate	95-126	interleukin 6	Homo sapiens	230-234
20953574-5	2011	Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1.	Tetradecanoylphorbol Acetate	95-126	signal transducer and activator of transcription 3	Homo sapiens	302-352
20953574-5	2011	Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1.	Tetradecanoylphorbol Acetate	95-126	signal transducer and activator of transcription 3	Homo sapiens	354-359
20953574-5	2011	Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1.	Tetradecanoylphorbol Acetate	95-126	GATA binding protein 1	Homo sapiens	366-372
20953574-5	2011	Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1.	Tetradecanoylphorbol Acetate	128-131	nuclear factor kappa B subunit 1	Homo sapiens	209-218
20953574-5	2011	Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1.	Tetradecanoylphorbol Acetate	128-131	interleukin 6	Homo sapiens	230-234
20953574-5	2011	Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1.	Tetradecanoylphorbol Acetate	128-131	signal transducer and activator of transcription 3	Homo sapiens	302-352
20953574-5	2011	Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1.	Tetradecanoylphorbol Acetate	128-131	signal transducer and activator of transcription 3	Homo sapiens	354-359
20953574-5	2011	Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1.	Tetradecanoylphorbol Acetate	128-131	GATA binding protein 1	Homo sapiens	366-372
20953574-9	2011	In Rab7b-silenced cells, PMA-induced activation of NF-kappaB, IL-6 production, and megakaryocytic differentiation are impaired.	Tetradecanoylphorbol Acetate	25-28	nuclear factor kappa B subunit 1	Homo sapiens	51-60
20953574-9	2011	In Rab7b-silenced cells, PMA-induced activation of NF-kappaB, IL-6 production, and megakaryocytic differentiation are impaired.	Tetradecanoylphorbol Acetate	25-28	interleukin 6	Homo sapiens	62-66
20935675-5	2011	Moreover, Tpl2(-/-) mice treated with TPA experienced significantly higher nuclear factor kappaB (NF-kappaB) activation, edema, infiltrating neutrophils and production of proinflammatory cytokines than did WT mice.	Tetradecanoylphorbol Acetate	38-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-96
20935675-5	2011	Moreover, Tpl2(-/-) mice treated with TPA experienced significantly higher nuclear factor kappaB (NF-kappaB) activation, edema, infiltrating neutrophils and production of proinflammatory cytokines than did WT mice.	Tetradecanoylphorbol Acetate	38-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	98-107
19576641-0	2011	Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	100-103	mitogen-activated protein kinase 14	Homo sapiens	74-77
21375937-4	2011	RESULTS: RT-PCR or Western blot showed that the expressions of MDR1 and P-gp were significantly higher in MCF-7Taxol cells exposed to PMA stimuli (both P0.05).	Tetradecanoylphorbol Acetate	134-137	ATP binding cassette subfamily B member 1	Homo sapiens	72-76
21375937-2	2011	METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot were used to determine the expressions of protein kinase Calpha (PKCalpha) and multidrug resistance-related genes ABCG2, ABCC1, MDR1, and P-glycoprotein (P-gp) in MCF-7Taxol cells after treatment with chelerythrine and phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	302-333	protein kinase C alpha	Homo sapiens	125-146
21375937-2	2011	METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot were used to determine the expressions of protein kinase Calpha (PKCalpha) and multidrug resistance-related genes ABCG2, ABCC1, MDR1, and P-glycoprotein (P-gp) in MCF-7Taxol cells after treatment with chelerythrine and phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	335-338	protein kinase C alpha	Homo sapiens	125-146
21375937-4	2011	RESULTS: RT-PCR or Western blot showed that the expressions of MDR1 and P-gp were significantly higher in MCF-7Taxol cells exposed to PMA stimuli (both P0.05).	Tetradecanoylphorbol Acetate	134-137	ATP binding cassette subfamily B member 1	Homo sapiens	63-67
20959602-8	2011	Reciprocally, AP-1 TFs were up-regulated by RUNX1 after 12-O-tetradecanoylphorbol-13-acetate induction and recruited to RUNX1-occupied sites lacking AP-1 motifs.	Tetradecanoylphorbol Acetate	56-92	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-18
21415525-0	2011	Tumor necrosis factor-alpha-nuclear factor-kappa B-signaling enhances St2b2 expression during 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia.	Tetradecanoylphorbol Acetate	94-130	tumor necrosis factor	Mus musculus	0-27
21173226-4	2011	Histological analysis showed high connexin 43 coupling, few inflammatory cells, and low fibrotic markers in myocardium implanted with these phorbol myristate acetate-activated MSCs.	Tetradecanoylphorbol Acetate	140-165	gap junction protein, alpha 1	Rattus norvegicus	34-45
21415525-7	2011	Furthermore, treatment with TNFalpha-siRNA or anti-TNF receptor antibodies reduced the TPA-induced enhancement of St2b2 expression.	Tetradecanoylphorbol Acetate	87-90	tumor necrosis factor	Mus musculus	28-36
21692564-5	2011	In these lines, virus reactivation could be induced by a phorbol 12-myristate 13-acetate (PMA) treatment that resulted in a marked increase of the production HIV-1 p24 antigen and appearance of the infectious virus.	Tetradecanoylphorbol Acetate	57-88	transmembrane p24 trafficking protein 2	Homo sapiens	164-167
21692564-5	2011	In these lines, virus reactivation could be induced by a phorbol 12-myristate 13-acetate (PMA) treatment that resulted in a marked increase of the production HIV-1 p24 antigen and appearance of the infectious virus.	Tetradecanoylphorbol Acetate	90-93	transmembrane p24 trafficking protein 2	Homo sapiens	164-167
21415525-8	2011	Treatment with BAY 11-7082, a specific inhibitor of nuclear factor-kappa B (NF-kappaB), diminished TPA-induced St2b2 expression.	Tetradecanoylphorbol Acetate	99-102	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	52-74
21415525-0	2011	Tumor necrosis factor-alpha-nuclear factor-kappa B-signaling enhances St2b2 expression during 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia.	Tetradecanoylphorbol Acetate	94-130	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	28-50
21415525-8	2011	Treatment with BAY 11-7082, a specific inhibitor of nuclear factor-kappa B (NF-kappaB), diminished TPA-induced St2b2 expression.	Tetradecanoylphorbol Acetate	99-102	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-85
21628878-2	2011	SA significantly inhibited phorbol myristate acetate (PMA) plus A23187-induced the production and expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human mast cell (HMC)-1 cells.	Tetradecanoylphorbol Acetate	27-52	interleukin 6	Homo sapiens	112-130
21415525-9	2011	These results suggested that enhancement of St2b2 expression by TPA treatment occurs mainly through the TNFalpha-NF-kappaB inflammatory signaling pathway, which in turn leads to increased CS concentrations in epidermal cells and hyperplasia.	Tetradecanoylphorbol Acetate	64-67	tumor necrosis factor	Mus musculus	104-112
21415525-9	2011	These results suggested that enhancement of St2b2 expression by TPA treatment occurs mainly through the TNFalpha-NF-kappaB inflammatory signaling pathway, which in turn leads to increased CS concentrations in epidermal cells and hyperplasia.	Tetradecanoylphorbol Acetate	64-67	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
21481849-0	2011	alphaVbeta3-integrin expression through ERK activation mediates cell attachment and is necessary for production of tumor necrosis factor alpha in monocytic THP-1 cells stimulated by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	182-207	mitogen-activated protein kinase 1	Homo sapiens	40-43
21481849-0	2011	alphaVbeta3-integrin expression through ERK activation mediates cell attachment and is necessary for production of tumor necrosis factor alpha in monocytic THP-1 cells stimulated by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	182-207	tumor necrosis factor	Homo sapiens	115-142
21481849-5	2011	Addition of phorbol myristate acetate (PMA) for THP-1 cell activation induced cell adhesion in parallel with TNFalpha production.	Tetradecanoylphorbol Acetate	12-37	tumor necrosis factor	Homo sapiens	109-117
21481849-5	2011	Addition of phorbol myristate acetate (PMA) for THP-1 cell activation induced cell adhesion in parallel with TNFalpha production.	Tetradecanoylphorbol Acetate	39-42	tumor necrosis factor	Homo sapiens	109-117
20974686-6	2011	Treatment of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), an inducer of COX-2 or PGE2, enhanced cell migration, whereas berberine inhibited TPA- or PGE2-promoted cell migration.	Tetradecanoylphorbol Acetate	28-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
20974686-6	2011	Treatment of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), an inducer of COX-2 or PGE2, enhanced cell migration, whereas berberine inhibited TPA- or PGE2-promoted cell migration.	Tetradecanoylphorbol Acetate	66-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
21628878-2	2011	SA significantly inhibited phorbol myristate acetate (PMA) plus A23187-induced the production and expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human mast cell (HMC)-1 cells.	Tetradecanoylphorbol Acetate	27-52	tumor necrosis factor	Homo sapiens	135-168
21628878-2	2011	SA significantly inhibited phorbol myristate acetate (PMA) plus A23187-induced the production and expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human mast cell (HMC)-1 cells.	Tetradecanoylphorbol Acetate	54-57	interleukin 6	Homo sapiens	112-130
21628878-2	2011	SA significantly inhibited phorbol myristate acetate (PMA) plus A23187-induced the production and expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human mast cell (HMC)-1 cells.	Tetradecanoylphorbol Acetate	54-57	tumor necrosis factor	Homo sapiens	135-168
21625419-5	2011	Human brain microvascular endothelial cells were treated with a combination of phorbol 12-myristate 13-acetate (PMA), a carcinogen documented to increase MMP-9 and COX-2 through NF-kappaB, and several naturally occurring flavonoids.	Tetradecanoylphorbol Acetate	79-110	nuclear factor kappa B subunit 1	Homo sapiens	178-187
21039753-12	2011	The results of the present study suggest that artemisinin inhibits EMMPRIN and MMP-9 expression and activity by suppressing the PKCdelta/ERK/p38 cascade in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	156-159	mitogen-activated protein kinase 1	Homo sapiens	137-140
21039753-12	2011	The results of the present study suggest that artemisinin inhibits EMMPRIN and MMP-9 expression and activity by suppressing the PKCdelta/ERK/p38 cascade in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	156-159	mitogen-activated protein kinase 1	Homo sapiens	141-144
21625419-5	2011	Human brain microvascular endothelial cells were treated with a combination of phorbol 12-myristate 13-acetate (PMA), a carcinogen documented to increase MMP-9 and COX-2 through NF-kappaB, and several naturally occurring flavonoids.	Tetradecanoylphorbol Acetate	79-110	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
21039753-0	2011	Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cdelta/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages.	Tetradecanoylphorbol Acetate	201-226	mitogen-activated protein kinase 1	Homo sapiens	148-151
21039753-0	2011	Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cdelta/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages.	Tetradecanoylphorbol Acetate	201-226	GLI family zinc finger 2	Homo sapiens	235-240
21625419-5	2011	Human brain microvascular endothelial cells were treated with a combination of phorbol 12-myristate 13-acetate (PMA), a carcinogen documented to increase MMP-9 and COX-2 through NF-kappaB, and several naturally occurring flavonoids.	Tetradecanoylphorbol Acetate	112-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
21625419-5	2011	Human brain microvascular endothelial cells were treated with a combination of phorbol 12-myristate 13-acetate (PMA), a carcinogen documented to increase MMP-9 and COX-2 through NF-kappaB, and several naturally occurring flavonoids.	Tetradecanoylphorbol Acetate	112-115	nuclear factor kappa B subunit 1	Homo sapiens	178-187
21076887-4	2011	Using chemical inhibitors and antibodies against PKCs, delivered into cells by the Chariot transfection system, we found that nPKCs activate ERK through transphosphorylation of PKD1, the blockage of which prevented PMA-stimulated ERK activation.	Tetradecanoylphorbol Acetate	215-218	mitogen-activated protein kinase 1	Homo sapiens	141-144
21047949-3	2011	In this study, we demonstrate that MA-10 mouse Leydig tumor cells express several PKC isoforms to varying levels and that the activation of PKC signaling, by phorbol 12-myristate 13-acetate (PMA) elevated the expression and phosphorylation of PKCalpha, -delta, -epsilon, and -mu/protein kinase D (PKD).	Tetradecanoylphorbol Acetate	158-189	protein kinase C, alpha	Mus musculus	82-85
21047949-3	2011	In this study, we demonstrate that MA-10 mouse Leydig tumor cells express several PKC isoforms to varying levels and that the activation of PKC signaling, by phorbol 12-myristate 13-acetate (PMA) elevated the expression and phosphorylation of PKCalpha, -delta, -epsilon, and -mu/protein kinase D (PKD).	Tetradecanoylphorbol Acetate	158-189	protein kinase C, alpha	Mus musculus	140-143
21047949-3	2011	In this study, we demonstrate that MA-10 mouse Leydig tumor cells express several PKC isoforms to varying levels and that the activation of PKC signaling, by phorbol 12-myristate 13-acetate (PMA) elevated the expression and phosphorylation of PKCalpha, -delta, -epsilon, and -mu/protein kinase D (PKD).	Tetradecanoylphorbol Acetate	158-189	protein kinase C, alpha	Mus musculus	243-295
21047949-3	2011	In this study, we demonstrate that MA-10 mouse Leydig tumor cells express several PKC isoforms to varying levels and that the activation of PKC signaling, by phorbol 12-myristate 13-acetate (PMA) elevated the expression and phosphorylation of PKCalpha, -delta, -epsilon, and -mu/protein kinase D (PKD).	Tetradecanoylphorbol Acetate	191-194	protein kinase C, alpha	Mus musculus	82-85
21047949-3	2011	In this study, we demonstrate that MA-10 mouse Leydig tumor cells express several PKC isoforms to varying levels and that the activation of PKC signaling, by phorbol 12-myristate 13-acetate (PMA) elevated the expression and phosphorylation of PKCalpha, -delta, -epsilon, and -mu/protein kinase D (PKD).	Tetradecanoylphorbol Acetate	191-194	protein kinase C, alpha	Mus musculus	140-143
21047949-3	2011	In this study, we demonstrate that MA-10 mouse Leydig tumor cells express several PKC isoforms to varying levels and that the activation of PKC signaling, by phorbol 12-myristate 13-acetate (PMA) elevated the expression and phosphorylation of PKCalpha, -delta, -epsilon, and -mu/protein kinase D (PKD).	Tetradecanoylphorbol Acetate	191-194	protein kinase C, alpha	Mus musculus	243-295
21076887-4	2011	Using chemical inhibitors and antibodies against PKCs, delivered into cells by the Chariot transfection system, we found that nPKCs activate ERK through transphosphorylation of PKD1, the blockage of which prevented PMA-stimulated ERK activation.	Tetradecanoylphorbol Acetate	215-218	mitogen-activated protein kinase 1	Homo sapiens	230-233
21670559-3	2011	METHODS: Human THP-1 monocytes were preincubated with Phorbol-12-myristate- 13-acetate (PMA) and oxidized low density lipoprotein (ox-LDL) to form foam cells.	Tetradecanoylphorbol Acetate	54-86	GLI family zinc finger 2	Homo sapiens	15-20
21646795-8	2011	Tr1 cells were defined as CD4+CD25+ T cells that predominantly produce IL-10 when costimulated with phorbol myristate acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	100-125	CD4 molecule	Homo sapiens	26-29
21646795-8	2011	Tr1 cells were defined as CD4+CD25+ T cells that predominantly produce IL-10 when costimulated with phorbol myristate acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	127-130	CD4 molecule	Homo sapiens	26-29
21670559-3	2011	METHODS: Human THP-1 monocytes were preincubated with Phorbol-12-myristate- 13-acetate (PMA) and oxidized low density lipoprotein (ox-LDL) to form foam cells.	Tetradecanoylphorbol Acetate	88-91	GLI family zinc finger 2	Homo sapiens	15-20
20339310-8	2011	PKCtheta pseudosubstrate significantly reduced the phorbol 3-myristate 12-acetate (PMA)-induced phosphorylation of ERK.	Tetradecanoylphorbol Acetate	83-86	mitogen-activated protein kinase 1	Mus musculus	115-118
21077177-1	2011	Leukemic cell lines, such as U937, THP-1, and HL60 cells, can differentiate into macrophages following exposure to various agents including 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro.	Tetradecanoylphorbol Acetate	140-176	GLI family zinc finger 2	Homo sapiens	35-40
21077177-1	2011	Leukemic cell lines, such as U937, THP-1, and HL60 cells, can differentiate into macrophages following exposure to various agents including 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro.	Tetradecanoylphorbol Acetate	178-181	GLI family zinc finger 2	Homo sapiens	35-40
21077177-4	2011	Recently, the reduction of Cu/Zn-SOD and the induction of Mn-SOD by TPA in leukemic cells have been reported; however, the regulation of EC-SOD by TPA remains poorly understood.	Tetradecanoylphorbol Acetate	147-150	superoxide dismutase 3	Homo sapiens	137-143
21077177-5	2011	Here, we explored the regulation of EC-SOD during the monocytic differentiation of U937 cells by TPA.	Tetradecanoylphorbol Acetate	97-100	superoxide dismutase 3	Homo sapiens	36-42
21077177-10	2011	Overall, our results suggest that the expression of EC-SOD is decreased by TPA through intracellular signaling consisting of PKC, NOX-derived ROS and MEK/ERK, but not of NF-kappaB signaling.	Tetradecanoylphorbol Acetate	75-78	superoxide dismutase 3	Homo sapiens	52-58
21077177-10	2011	Overall, our results suggest that the expression of EC-SOD is decreased by TPA through intracellular signaling consisting of PKC, NOX-derived ROS and MEK/ERK, but not of NF-kappaB signaling.	Tetradecanoylphorbol Acetate	75-78	mitogen-activated protein kinase kinase 7	Homo sapiens	150-153
21077177-10	2011	Overall, our results suggest that the expression of EC-SOD is decreased by TPA through intracellular signaling consisting of PKC, NOX-derived ROS and MEK/ERK, but not of NF-kappaB signaling.	Tetradecanoylphorbol Acetate	75-78	mitogen-activated protein kinase 1	Homo sapiens	154-157
22096365-5	2011	Procarcinogenic signaling was induced with phorbol 12-myristate 13-acetate (PMA) and found to trigger the proinflammatory marker cyclooxygenase-2 (COX-2) and endoplasmic reticulum (ER) stress marker GRP78 expression, whose inductions were potentiated when PMA was combined with 2-DG treatment.	Tetradecanoylphorbol Acetate	43-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	129-145
22096365-5	2011	Procarcinogenic signaling was induced with phorbol 12-myristate 13-acetate (PMA) and found to trigger the proinflammatory marker cyclooxygenase-2 (COX-2) and endoplasmic reticulum (ER) stress marker GRP78 expression, whose inductions were potentiated when PMA was combined with 2-DG treatment.	Tetradecanoylphorbol Acetate	43-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	147-152
22096365-5	2011	Procarcinogenic signaling was induced with phorbol 12-myristate 13-acetate (PMA) and found to trigger the proinflammatory marker cyclooxygenase-2 (COX-2) and endoplasmic reticulum (ER) stress marker GRP78 expression, whose inductions were potentiated when PMA was combined with 2-DG treatment.	Tetradecanoylphorbol Acetate	43-74	heat shock protein family A (Hsp70) member 5	Homo sapiens	199-204
22096365-5	2011	Procarcinogenic signaling was induced with phorbol 12-myristate 13-acetate (PMA) and found to trigger the proinflammatory marker cyclooxygenase-2 (COX-2) and endoplasmic reticulum (ER) stress marker GRP78 expression, whose inductions were potentiated when PMA was combined with 2-DG treatment.	Tetradecanoylphorbol Acetate	76-79	prostaglandin-endoperoxide synthase 2	Homo sapiens	129-145
22096365-5	2011	Procarcinogenic signaling was induced with phorbol 12-myristate 13-acetate (PMA) and found to trigger the proinflammatory marker cyclooxygenase-2 (COX-2) and endoplasmic reticulum (ER) stress marker GRP78 expression, whose inductions were potentiated when PMA was combined with 2-DG treatment.	Tetradecanoylphorbol Acetate	76-79	prostaglandin-endoperoxide synthase 2	Homo sapiens	147-152
22096365-5	2011	Procarcinogenic signaling was induced with phorbol 12-myristate 13-acetate (PMA) and found to trigger the proinflammatory marker cyclooxygenase-2 (COX-2) and endoplasmic reticulum (ER) stress marker GRP78 expression, whose inductions were potentiated when PMA was combined with 2-DG treatment.	Tetradecanoylphorbol Acetate	76-79	heat shock protein family A (Hsp70) member 5	Homo sapiens	199-204
21261439-6	2011	Additionally, ex vivo interleukin-4 (IL-4), IL-5, and IL-6 production by in vitro anti-CD3- or phorbol myristate acetate-stimulated CD4+ T-cells was not affected.	Tetradecanoylphorbol Acetate	95-120	interleukin 6	Mus musculus	54-58
20840869-5	2011	Soluble factors released by OECs significantly moderated the astrocytic NFkappaB translocation induced by either PMA/calcium ionophore or microglia-derived factors (p&lt;0.001).	Tetradecanoylphorbol Acetate	113-116	nuclear factor kappa B subunit 1	Homo sapiens	72-80
21220488-7	2011	PMA-induced skin carcinogenesis in RLIP76(+/+) mouse was suppressed completely by depletion of either PKCalpha or RLIP76 by siRNA or antisense and could be restored by topical application of RLIP76 protein in RLIP76(-/-) mouse skin.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Mus musculus	102-110
21131601-5	2011	With low-dose phorbol 12-myristate 13-acetate (PMA) or anti-IgM treatment, TGF-beta sensitivity was restored by stabilizing TbetaRII expression and sustaining TGF-beta signaling.	Tetradecanoylphorbol Acetate	14-45	transforming growth factor beta 1	Homo sapiens	75-83
21131601-5	2011	With low-dose phorbol 12-myristate 13-acetate (PMA) or anti-IgM treatment, TGF-beta sensitivity was restored by stabilizing TbetaRII expression and sustaining TGF-beta signaling.	Tetradecanoylphorbol Acetate	14-45	transforming growth factor beta 1	Homo sapiens	159-167
21131601-5	2011	With low-dose phorbol 12-myristate 13-acetate (PMA) or anti-IgM treatment, TGF-beta sensitivity was restored by stabilizing TbetaRII expression and sustaining TGF-beta signaling.	Tetradecanoylphorbol Acetate	47-50	transforming growth factor beta 1	Homo sapiens	75-83
21131601-5	2011	With low-dose phorbol 12-myristate 13-acetate (PMA) or anti-IgM treatment, TGF-beta sensitivity was restored by stabilizing TbetaRII expression and sustaining TGF-beta signaling.	Tetradecanoylphorbol Acetate	47-50	transforming growth factor beta 1	Homo sapiens	159-167
21129776-5	2011	Finally, in line with the known TPA pathway, we found that nuclear proteins could bind a sequence corresponding to a unique AP1 site on promoter 2 selectively in the activated cell fraction.	Tetradecanoylphorbol Acetate	32-35	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	124-127
21966389-4	2011	Potentiation of anti-IgE- induced and calcium ionophore/PMA-induced degranulation was augmented in mast cells cultured with IL-4, and this effect was reduced or abolished by pre-treatment with A(2B)siRNA and selective A(2B) receptor antagonists, respectively.	Tetradecanoylphorbol Acetate	56-59	interleukin 4	Homo sapiens	124-128
21269946-2	2011	METHIDS: THP-1 monocytes were induced to differentiate into macrophages by a 24-h incubation with 160 nmol/L PMA.	Tetradecanoylphorbol Acetate	109-112	GLI family zinc finger 2	Homo sapiens	9-14
20669087-10	2011	Likewise, the constitutive nuclear NF- kappaB (p65) activity as well as phorbol 12-myristate 13-acetate (PMA)- and sodium N-butyrate (SnB)-induced AP-1 binding activity in Raji cells were significantly reduced following treatment with maslinic acid.	Tetradecanoylphorbol Acetate	72-103	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	147-151
20669087-10	2011	Likewise, the constitutive nuclear NF- kappaB (p65) activity as well as phorbol 12-myristate 13-acetate (PMA)- and sodium N-butyrate (SnB)-induced AP-1 binding activity in Raji cells were significantly reduced following treatment with maslinic acid.	Tetradecanoylphorbol Acetate	105-108	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	147-151
22812190-6	2011	PMA induced a metastatic phenotype in colorectal cancer cells, as indicated by cell viability, migration and invasion capacity, and ERK1/2 phosphorylation, whereas SPHK1 siRNA transfection suppressed the metastatic phenotype of tumor cells and antagonized PMA"s effects.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	132-138
22812190-8	2011	Suppression of SPHK1 expression suppresses the PMA-induced metastatic phenotype via ERK1/2 phosphorylation in human colorectal cancer cells.	Tetradecanoylphorbol Acetate	47-50	mitogen-activated protein kinase 3	Homo sapiens	84-90
21857090-4	2011	Western blot analysis documented that in concentrations of 10 and 100 muM, N-f-5HT isomers significantly decreased PMA-induced phosphorylation of PKC alpha/beta II.	Tetradecanoylphorbol Acetate	115-118	latexin	Homo sapiens	70-73
21857090-4	2011	Western blot analysis documented that in concentrations of 10 and 100 muM, N-f-5HT isomers significantly decreased PMA-induced phosphorylation of PKC alpha/beta II.	Tetradecanoylphorbol Acetate	115-118	protein kinase C alpha	Homo sapiens	146-163
22022384-6	2011	EGCG inhibits 12-O-tetradecanoylphorbol-13-acetate-, an inducer of COX-2, and PGE(2)-induced cell migration of cells.	Tetradecanoylphorbol Acetate	14-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
21858203-2	2011	Interaction of urokinase-type plasminogen activator (uPA) with its cell surface receptor (uPAR) has been shown to favor virion accumulation in such sub-cellular compartment in primary monocyte-derived macrophages and chronically infected promonocytic U1 cells differentiated into macrophage-like cells by stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	322-347	plasminogen activator, urokinase	Homo sapiens	15-51
21858203-2	2011	Interaction of urokinase-type plasminogen activator (uPA) with its cell surface receptor (uPAR) has been shown to favor virion accumulation in such sub-cellular compartment in primary monocyte-derived macrophages and chronically infected promonocytic U1 cells differentiated into macrophage-like cells by stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	349-352	plasminogen activator, urokinase	Homo sapiens	15-51
21858203-2	2011	Interaction of urokinase-type plasminogen activator (uPA) with its cell surface receptor (uPAR) has been shown to favor virion accumulation in such sub-cellular compartment in primary monocyte-derived macrophages and chronically infected promonocytic U1 cells differentiated into macrophage-like cells by stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	322-347	plasminogen activator, urokinase	Homo sapiens	53-56
21858203-2	2011	Interaction of urokinase-type plasminogen activator (uPA) with its cell surface receptor (uPAR) has been shown to favor virion accumulation in such sub-cellular compartment in primary monocyte-derived macrophages and chronically infected promonocytic U1 cells differentiated into macrophage-like cells by stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	349-352	plasminogen activator, urokinase	Homo sapiens	53-56
21738696-5	2011	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate, an inducer of COX-2, enhanced the phosphorylation of ERK1/2, a protein of mitogen-activated protein kinase family, and subsequently cell migration whereas both GSPs and celecoxib significantly inhibited 12-O-tetradecanoylphorbol-13-acetate-promoted cell migration as well as phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	24-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
21901143-4	2011	In this report, we showed that the replication and transcription activator (RTA) encoded by KSHV ORF 50, a key regulator for KSHV reactivation from latent to lytic infection, upregulates the mRNA and protein levels of Bcl-2 in 293 cells, and TPA-induced KSHV-infected cells.	Tetradecanoylphorbol Acetate	242-245	BCL2 apoptosis regulator	Homo sapiens	218-223
21738696-5	2011	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate, an inducer of COX-2, enhanced the phosphorylation of ERK1/2, a protein of mitogen-activated protein kinase family, and subsequently cell migration whereas both GSPs and celecoxib significantly inhibited 12-O-tetradecanoylphorbol-13-acetate-promoted cell migration as well as phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	24-60	mitogen-activated protein kinase 3	Homo sapiens	115-121
21738696-5	2011	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate, an inducer of COX-2, enhanced the phosphorylation of ERK1/2, a protein of mitogen-activated protein kinase family, and subsequently cell migration whereas both GSPs and celecoxib significantly inhibited 12-O-tetradecanoylphorbol-13-acetate-promoted cell migration as well as phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	24-60	mitogen-activated protein kinase 3	Homo sapiens	356-362
21738696-5	2011	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate, an inducer of COX-2, enhanced the phosphorylation of ERK1/2, a protein of mitogen-activated protein kinase family, and subsequently cell migration whereas both GSPs and celecoxib significantly inhibited 12-O-tetradecanoylphorbol-13-acetate-promoted cell migration as well as phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	265-301	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
21738696-5	2011	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate, an inducer of COX-2, enhanced the phosphorylation of ERK1/2, a protein of mitogen-activated protein kinase family, and subsequently cell migration whereas both GSPs and celecoxib significantly inhibited 12-O-tetradecanoylphorbol-13-acetate-promoted cell migration as well as phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	265-301	mitogen-activated protein kinase 3	Homo sapiens	115-121
21603612-4	2011	Treatment with a combination of phorbol 12-myristate 13-acetate (PMA) plus the calcium ionophore A23187 (Io) increased NFAT activation and TRAIL expression; pretreatment with the calcineurin inhibitor cyclosporine A (CsA), an antagonist of NFAT signaling, diminished NFAT activation and TRAIL induction.	Tetradecanoylphorbol Acetate	32-63	TNF superfamily member 10	Homo sapiens	139-144
21603612-4	2011	Treatment with a combination of phorbol 12-myristate 13-acetate (PMA) plus the calcium ionophore A23187 (Io) increased NFAT activation and TRAIL expression; pretreatment with the calcineurin inhibitor cyclosporine A (CsA), an antagonist of NFAT signaling, diminished NFAT activation and TRAIL induction.	Tetradecanoylphorbol Acetate	32-63	TNF superfamily member 10	Homo sapiens	287-292
21603612-4	2011	Treatment with a combination of phorbol 12-myristate 13-acetate (PMA) plus the calcium ionophore A23187 (Io) increased NFAT activation and TRAIL expression; pretreatment with the calcineurin inhibitor cyclosporine A (CsA), an antagonist of NFAT signaling, diminished NFAT activation and TRAIL induction.	Tetradecanoylphorbol Acetate	65-68	TNF superfamily member 10	Homo sapiens	139-144
21603612-4	2011	Treatment with a combination of phorbol 12-myristate 13-acetate (PMA) plus the calcium ionophore A23187 (Io) increased NFAT activation and TRAIL expression; pretreatment with the calcineurin inhibitor cyclosporine A (CsA), an antagonist of NFAT signaling, diminished NFAT activation and TRAIL induction.	Tetradecanoylphorbol Acetate	65-68	TNF superfamily member 10	Homo sapiens	287-292
21127341-1	2010	In a previous work we showed that a 6 mT static magnetic field (SMF) interferes with monocyte/macrophage 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of promonocytes (U937 cells) and monocytes (THP-1 cells).	Tetradecanoylphorbol Acetate	105-141	GLI family zinc finger 2	Homo sapiens	216-221
22166649-7	2010	The effects of the protein kinase A (PKA) activator 8-Br-cAMP and protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) on MAPK phosphorylation, and the effects of the PKA inhibitor H89 and PKC inhibitor calphostin C on MAPK phosphorylation and CTGF expression were detected by immunoblotting assay.	Tetradecanoylphorbol Acetate	132-135	mitogen-activated protein kinase 1	Homo sapiens	140-144
21187486-9	2010	CONCLUSION: Consistent with these findings, the inhibition of PKC prevented PTHrP-induced activation of ERK1/2, whereas 12-O-tetradecanoylphorbol-13-acetate (TPA), a stimulator of PKC, up-regulated the PTHrP-induced activation of ERK1/2.	Tetradecanoylphorbol Acetate	120-156	proline rich transmembrane protein 2	Homo sapiens	180-183
21187486-9	2010	CONCLUSION: Consistent with these findings, the inhibition of PKC prevented PTHrP-induced activation of ERK1/2, whereas 12-O-tetradecanoylphorbol-13-acetate (TPA), a stimulator of PKC, up-regulated the PTHrP-induced activation of ERK1/2.	Tetradecanoylphorbol Acetate	120-156	mitogen-activated protein kinase 3	Homo sapiens	230-236
21187486-9	2010	CONCLUSION: Consistent with these findings, the inhibition of PKC prevented PTHrP-induced activation of ERK1/2, whereas 12-O-tetradecanoylphorbol-13-acetate (TPA), a stimulator of PKC, up-regulated the PTHrP-induced activation of ERK1/2.	Tetradecanoylphorbol Acetate	158-161	proline rich transmembrane protein 2	Homo sapiens	180-183
21187486-9	2010	CONCLUSION: Consistent with these findings, the inhibition of PKC prevented PTHrP-induced activation of ERK1/2, whereas 12-O-tetradecanoylphorbol-13-acetate (TPA), a stimulator of PKC, up-regulated the PTHrP-induced activation of ERK1/2.	Tetradecanoylphorbol Acetate	158-161	mitogen-activated protein kinase 3	Homo sapiens	230-236
20826143-0	2010	Phorbol 12-myristate 13-acetate inhibits the antilipolytic action of insulin, probably via the activity of protein kinase Cepsilon.	Tetradecanoylphorbol Acetate	0-31	insulin	Homo sapiens	69-76
20826143-2	2010	In this work, the effect of the PKC activator phorbol 12-myristate 13-acetate (PMA) on the antilipolytic action of insulin was determined by analyzing lipolysis induced by a beta3-adrenoceptor agonist CL 316243.	Tetradecanoylphorbol Acetate	46-77	protein kinase C alpha	Homo sapiens	32-35
20826143-2	2010	In this work, the effect of the PKC activator phorbol 12-myristate 13-acetate (PMA) on the antilipolytic action of insulin was determined by analyzing lipolysis induced by a beta3-adrenoceptor agonist CL 316243.	Tetradecanoylphorbol Acetate	46-77	insulin	Homo sapiens	115-122
20826143-2	2010	In this work, the effect of the PKC activator phorbol 12-myristate 13-acetate (PMA) on the antilipolytic action of insulin was determined by analyzing lipolysis induced by a beta3-adrenoceptor agonist CL 316243.	Tetradecanoylphorbol Acetate	79-82	protein kinase C alpha	Homo sapiens	32-35
20826143-2	2010	In this work, the effect of the PKC activator phorbol 12-myristate 13-acetate (PMA) on the antilipolytic action of insulin was determined by analyzing lipolysis induced by a beta3-adrenoceptor agonist CL 316243.	Tetradecanoylphorbol Acetate	79-82	insulin	Homo sapiens	115-122
20826143-3	2010	PMA inhibited the insulin antilipolytic action.	Tetradecanoylphorbol Acetate	0-3	insulin	Homo sapiens	18-25
20826143-4	2010	The pan-PKC inhibitors GF 109203X and chelerythrine inhibited the PMA effect, but the PKCalpha/beta inhibitors Go 6976 and CGP 53353 did not.	Tetradecanoylphorbol Acetate	66-69	protein kinase C alpha	Homo sapiens	8-11
20826143-6	2010	Inhibitors of phosphatidylinositol 3-kinase (PI3-K), Akt, and phosphodiesterase 3B (PDE3B) diminished the PMA effect.	Tetradecanoylphorbol Acetate	106-109	AKT serine/threonine kinase 1	Homo sapiens	53-56
20826143-7	2010	PMA inhibited insulin-stimulated phosphorylation of Tyr in insulin receptor beta subunit and Ser/Thr in Akt.	Tetradecanoylphorbol Acetate	0-3	insulin	Homo sapiens	14-21
21127341-1	2010	In a previous work we showed that a 6 mT static magnetic field (SMF) interferes with monocyte/macrophage 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of promonocytes (U937 cells) and monocytes (THP-1 cells).	Tetradecanoylphorbol Acetate	143-146	GLI family zinc finger 2	Homo sapiens	216-221
20826143-7	2010	PMA inhibited insulin-stimulated phosphorylation of Tyr in insulin receptor beta subunit and Ser/Thr in Akt.	Tetradecanoylphorbol Acetate	0-3	insulin	Homo sapiens	59-66
20826143-7	2010	PMA inhibited insulin-stimulated phosphorylation of Tyr in insulin receptor beta subunit and Ser/Thr in Akt.	Tetradecanoylphorbol Acetate	0-3	AKT serine/threonine kinase 1	Homo sapiens	104-107
21127341-6	2010	Conversely, the rate of phagocytosis of apoptotic cells increased under SMF exposure, while the number of apoptotic cells bound to the plasma membrane of isolated human Kupffer cells, Raw 264.7 macrophages and TPA-differentiated THP-1 and U937 cells decreased.	Tetradecanoylphorbol Acetate	210-213	GLI family zinc finger 2	Homo sapiens	229-234
20533305-4	2010	TRIC expression was induced by treatment with the PKC activator TPA and proinflammatory cytokines IL-1beta, TNFalpha, and IL-1alpha, whereas the changes were inhibited by a JNK inhibitor.	Tetradecanoylphorbol Acetate	64-67	MARVEL domain containing 2	Homo sapiens	0-4
20826149-0	2010	Butein downregulates phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in cancerous and non-cancerous breast cells.	Tetradecanoylphorbol Acetate	21-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
20826149-4	2010	This study examined the potential suppressive effect of the flavonoid on phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in the non-tumorigenic MCF-10A and cancerous MCF-7 breast cells.	Tetradecanoylphorbol Acetate	73-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
20826149-4	2010	This study examined the potential suppressive effect of the flavonoid on phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in the non-tumorigenic MCF-10A and cancerous MCF-7 breast cells.	Tetradecanoylphorbol Acetate	106-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
20826149-10	2010	This study showed that butein down-regulated PMA-induced COX-2 expression in both cancerous and non-cancerous breast cells, and such findings could provide the basis for pharmaceutical development of butein.	Tetradecanoylphorbol Acetate	45-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
20131957-0	2010	Hyul-Tong-Ryung suppresses PMA-induced MMP-9 expression by inhibiting AP-1-mediated gene expression via ERK 1/2 signaling pathway in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 3	Homo sapiens	104-111
20131957-5	2010	In addition, PMA-stimulated phosphorylation of extracellular signal regulated kinase 1/2 (ERK 1/2) was suppressed by HM treatment, whereas the phosphorylation of either c-Jun N-terminal kinase (JNK) or p38 mitogen-activated protein kinase (MAPK) was not affected.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 1	Homo sapiens	47-88
20131957-5	2010	In addition, PMA-stimulated phosphorylation of extracellular signal regulated kinase 1/2 (ERK 1/2) was suppressed by HM treatment, whereas the phosphorylation of either c-Jun N-terminal kinase (JNK) or p38 mitogen-activated protein kinase (MAPK) was not affected.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 3	Homo sapiens	90-97
20131957-5	2010	In addition, PMA-stimulated phosphorylation of extracellular signal regulated kinase 1/2 (ERK 1/2) was suppressed by HM treatment, whereas the phosphorylation of either c-Jun N-terminal kinase (JNK) or p38 mitogen-activated protein kinase (MAPK) was not affected.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 8	Homo sapiens	194-197
20131957-5	2010	In addition, PMA-stimulated phosphorylation of extracellular signal regulated kinase 1/2 (ERK 1/2) was suppressed by HM treatment, whereas the phosphorylation of either c-Jun N-terminal kinase (JNK) or p38 mitogen-activated protein kinase (MAPK) was not affected.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 14	Homo sapiens	202-238
20131957-5	2010	In addition, PMA-stimulated phosphorylation of extracellular signal regulated kinase 1/2 (ERK 1/2) was suppressed by HM treatment, whereas the phosphorylation of either c-Jun N-terminal kinase (JNK) or p38 mitogen-activated protein kinase (MAPK) was not affected.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 3	Homo sapiens	240-244
20386016-4	2010	The pharmacodynamics were measured by changes in ERK phosphorylation (pERK) in peripheral blood mononuclear cells, ex vivo stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	137-168	mitogen-activated protein kinase 1	Homo sapiens	49-52
20386016-4	2010	The pharmacodynamics were measured by changes in ERK phosphorylation (pERK) in peripheral blood mononuclear cells, ex vivo stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	170-173	mitogen-activated protein kinase 1	Homo sapiens	49-52
21234122-9	2010	Finally, we observed that selective A(2A)AR activation with CGS-21680 blocked PMA-induced ERK1/2 phosphorylation and modulated the overexpression of functional nuclear orphan receptors 4A.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 3	Homo sapiens	90-96
20554189-12	2010	Therefore, we have demonstrated that silibinin has an additive effect on TPA-induced growth arrest through the PI-3-kinase/Akt-dependent pathway.	Tetradecanoylphorbol Acetate	73-76	AKT serine/threonine kinase 1	Homo sapiens	123-126
20966433-2	2010	Previously, we mapped the 12-O-tetradecanoylphorbol-13-acetate (TPA) skin tumor promotion susceptibility locus, Psl1, to distal chromosome 9 in crosses of sensitive DBA/2 mice with relatively resistant C57BL/6 mice.	Tetradecanoylphorbol Acetate	26-62	promotion susceptibility QTL 1	Mus musculus	112-116
20966433-2	2010	Previously, we mapped the 12-O-tetradecanoylphorbol-13-acetate (TPA) skin tumor promotion susceptibility locus, Psl1, to distal chromosome 9 in crosses of sensitive DBA/2 mice with relatively resistant C57BL/6 mice.	Tetradecanoylphorbol Acetate	64-67	promotion susceptibility QTL 1	Mus musculus	112-116
20966433-9	2010	RESULTS: Analyses of congenic mice indicated that at least two loci, Psl1.1 and Psl1.2, map to distal chromosome 9 and confer susceptibility to skin tumor promotion by TPA.	Tetradecanoylphorbol Acetate	168-171	promotion susceptibility QTL 1	Mus musculus	69-73
20966433-9	2010	RESULTS: Analyses of congenic mice indicated that at least two loci, Psl1.1 and Psl1.2, map to distal chromosome 9 and confer susceptibility to skin tumor promotion by TPA.	Tetradecanoylphorbol Acetate	168-171	promotion susceptibility QTL 1	Mus musculus	80-84
20458747-0	2010	12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression.	Tetradecanoylphorbol Acetate	0-36	protein kinase C alpha	Homo sapiens	105-113
20458747-0	2010	12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression.	Tetradecanoylphorbol Acetate	0-36	mitogen-activated protein kinase 1	Homo sapiens	114-117
20458747-0	2010	12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression.	Tetradecanoylphorbol Acetate	0-36	nuclear factor kappa B subunit 1	Homo sapiens	118-127
20458747-2	2010	TPA-induced translocation of protein kinase C (PKC)alpha from the cytosol to membranes, and migration of GBM8401 elicited by TPA was suppressed by adding the PKCalpha inhibitors, GF109203X and H7.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	47-56
20458747-2	2010	TPA-induced translocation of protein kinase C (PKC)alpha from the cytosol to membranes, and migration of GBM8401 elicited by TPA was suppressed by adding the PKCalpha inhibitors, GF109203X and H7.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	158-166
20458747-2	2010	TPA-induced translocation of protein kinase C (PKC)alpha from the cytosol to membranes, and migration of GBM8401 elicited by TPA was suppressed by adding the PKCalpha inhibitors, GF109203X and H7.	Tetradecanoylphorbol Acetate	125-128	protein kinase C alpha	Homo sapiens	158-166
20458747-3	2010	Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 1	Homo sapiens	14-51
20458747-3	2010	Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 1	Homo sapiens	53-56
20458747-3	2010	Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 8	Homo sapiens	62-85
20458747-3	2010	Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 8	Homo sapiens	87-90
20458747-3	2010	Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 1	Homo sapiens	189-192
20458747-3	2010	Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 8	Homo sapiens	230-233
20875052-3	2010	In this study, the impact of IFN-gamma treatment on phorbol-12-myristate-13-acetate-differentiated THP-1 cells infected with Mycobacterium bovis was investigated.	Tetradecanoylphorbol Acetate	52-83	interferon gamma	Homo sapiens	29-38
20875052-3	2010	In this study, the impact of IFN-gamma treatment on phorbol-12-myristate-13-acetate-differentiated THP-1 cells infected with Mycobacterium bovis was investigated.	Tetradecanoylphorbol Acetate	52-83	GLI family zinc finger 2	Homo sapiens	99-104
20131957-7	2010	These results indicate that HM inhibits PMA-induced MMP-9 expression by blocking the activation of activator protein-1 (AP-1) via extracellular signal regulated kinase 1/2 (ERK 1/2) signaling pathway.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 1	Homo sapiens	130-171
20131957-7	2010	These results indicate that HM inhibits PMA-induced MMP-9 expression by blocking the activation of activator protein-1 (AP-1) via extracellular signal regulated kinase 1/2 (ERK 1/2) signaling pathway.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 3	Homo sapiens	173-180
21124749-7	2010	Propranolol not only inhibited PMA- induced phosphorylation of the extracellular signal-regulated kinase (Erk), but also that of IkappaB (IkappaB), preventing the IkappaB phosphorylation which is a prerequisite for IkappaB degradation.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 1	Homo sapiens	67-104
21124749-7	2010	Propranolol not only inhibited PMA- induced phosphorylation of the extracellular signal-regulated kinase (Erk), but also that of IkappaB (IkappaB), preventing the IkappaB phosphorylation which is a prerequisite for IkappaB degradation.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 1	Homo sapiens	106-109
21124749-9	2010	Although propranolol, at up to 100 muM, did not affect cell viability, it potentiated PMA- mediated signaling that ultimately led to diminished phosphorylation of Akt.	Tetradecanoylphorbol Acetate	86-89	AKT serine/threonine kinase 1	Homo sapiens	163-166
20458747-3	2010	Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 1	Homo sapiens	14-51
20458747-3	2010	Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 1	Homo sapiens	53-56
20458747-3	2010	Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 1	Homo sapiens	189-192
20458747-3	2010	Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 8	Homo sapiens	230-233
20458747-4	2010	Activation of NF-kappaB protein p65 nuclear translocation and IkappaBalpha protein phosphorylation with increased NF-kappaB-directed luciferase activity by TPA were observed, and these were blocked by the PD98059 and IkB inhibitor BAY117082 accompanied by reducing migration and MMP-9 activity induced by TPA in GBM8401 cells.	Tetradecanoylphorbol Acetate	156-159	nuclear factor kappa B subunit 1	Homo sapiens	14-23
20458747-4	2010	Activation of NF-kappaB protein p65 nuclear translocation and IkappaBalpha protein phosphorylation with increased NF-kappaB-directed luciferase activity by TPA were observed, and these were blocked by the PD98059 and IkB inhibitor BAY117082 accompanied by reducing migration and MMP-9 activity induced by TPA in GBM8401 cells.	Tetradecanoylphorbol Acetate	156-159	NFKB inhibitor alpha	Homo sapiens	62-74
20458747-4	2010	Activation of NF-kappaB protein p65 nuclear translocation and IkappaBalpha protein phosphorylation with increased NF-kappaB-directed luciferase activity by TPA were observed, and these were blocked by the PD98059 and IkB inhibitor BAY117082 accompanied by reducing migration and MMP-9 activity induced by TPA in GBM8401 cells.	Tetradecanoylphorbol Acetate	156-159	nuclear factor kappa B subunit 1	Homo sapiens	114-123
20458747-4	2010	Activation of NF-kappaB protein p65 nuclear translocation and IkappaBalpha protein phosphorylation with increased NF-kappaB-directed luciferase activity by TPA were observed, and these were blocked by the PD98059 and IkB inhibitor BAY117082 accompanied by reducing migration and MMP-9 activity induced by TPA in GBM8401 cells.	Tetradecanoylphorbol Acetate	305-308	nuclear factor kappa B subunit 1	Homo sapiens	14-23
20458747-4	2010	Activation of NF-kappaB protein p65 nuclear translocation and IkappaBalpha protein phosphorylation with increased NF-kappaB-directed luciferase activity by TPA were observed, and these were blocked by the PD98059 and IkB inhibitor BAY117082 accompanied by reducing migration and MMP-9 activity induced by TPA in GBM8401 cells.	Tetradecanoylphorbol Acetate	305-308	NFKB inhibitor alpha	Homo sapiens	62-74
20458747-4	2010	Activation of NF-kappaB protein p65 nuclear translocation and IkappaBalpha protein phosphorylation with increased NF-kappaB-directed luciferase activity by TPA were observed, and these were blocked by the PD98059 and IkB inhibitor BAY117082 accompanied by reducing migration and MMP-9 activity induced by TPA in GBM8401 cells.	Tetradecanoylphorbol Acetate	305-308	nuclear factor kappa B subunit 1	Homo sapiens	114-123
20458747-5	2010	Transfection of GBM8401 cells with PKCalpha siRNA specifically reduced PKCalpha protein expression with blocking TPA-induced MMP-9 activation and migration.	Tetradecanoylphorbol Acetate	113-116	protein kinase C alpha	Homo sapiens	35-43
20458747-5	2010	Transfection of GBM8401 cells with PKCalpha siRNA specifically reduced PKCalpha protein expression with blocking TPA-induced MMP-9 activation and migration.	Tetradecanoylphorbol Acetate	113-116	protein kinase C alpha	Homo sapiens	71-79
20533305-4	2010	TRIC expression was induced by treatment with the PKC activator TPA and proinflammatory cytokines IL-1beta, TNFalpha, and IL-1alpha, whereas the changes were inhibited by a JNK inhibitor.	Tetradecanoylphorbol Acetate	64-67	tumor necrosis factor	Homo sapiens	108-116
20533305-4	2010	TRIC expression was induced by treatment with the PKC activator TPA and proinflammatory cytokines IL-1beta, TNFalpha, and IL-1alpha, whereas the changes were inhibited by a JNK inhibitor.	Tetradecanoylphorbol Acetate	64-67	mitogen-activated protein kinase 8	Homo sapiens	173-176
20869211-6	2010	TPA-induced the phosphorylation of p38 MAPK and the elongation of dendrite length, suggesting that MKK6 may be involved in this process.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	35-38
20869211-6	2010	TPA-induced the phosphorylation of p38 MAPK and the elongation of dendrite length, suggesting that MKK6 may be involved in this process.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 6	Homo sapiens	99-103
20670683-5	2010	NCX (1 nM-50 muM) dose-dependently inhibited phorbol 12-myristate 13-acetate (PMA)-induced TNF-alpha release from monocytes (IC(50)=240 nM) and MDM (IC(50)=52 nM).	Tetradecanoylphorbol Acetate	45-76	latexin	Homo sapiens	13-16
20921526-3	2010	The myeloid-differentiating agents all-trans retinoic acid/PMA and histamine, the inflammatory mediator that inhibits promonocyte proliferation, induced an intracellular Ca(2+)-mediated PMV (as opposed to exosome) release from THP-1 promonocytes.	Tetradecanoylphorbol Acetate	59-62	GLI family zinc finger 2	Homo sapiens	227-232
21174945-4	2010	Phorbol 12-myristate 13-acetate (PMA) is known as PKC activator, significantly enhanced the c-mpl promoter activity and PKC inhibitor, 2-methylpiperazine dihydrochloride (H-7) suppressed the up-regulation of PMA-induced promoter activity and this effect decreased in a time-dependent manner.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	50-53
21174945-4	2010	Phorbol 12-myristate 13-acetate (PMA) is known as PKC activator, significantly enhanced the c-mpl promoter activity and PKC inhibitor, 2-methylpiperazine dihydrochloride (H-7) suppressed the up-regulation of PMA-induced promoter activity and this effect decreased in a time-dependent manner.	Tetradecanoylphorbol Acetate	0-31	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	92-97
21174945-4	2010	Phorbol 12-myristate 13-acetate (PMA) is known as PKC activator, significantly enhanced the c-mpl promoter activity and PKC inhibitor, 2-methylpiperazine dihydrochloride (H-7) suppressed the up-regulation of PMA-induced promoter activity and this effect decreased in a time-dependent manner.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	120-123
21174945-4	2010	Phorbol 12-myristate 13-acetate (PMA) is known as PKC activator, significantly enhanced the c-mpl promoter activity and PKC inhibitor, 2-methylpiperazine dihydrochloride (H-7) suppressed the up-regulation of PMA-induced promoter activity and this effect decreased in a time-dependent manner.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	50-53
21174945-4	2010	Phorbol 12-myristate 13-acetate (PMA) is known as PKC activator, significantly enhanced the c-mpl promoter activity and PKC inhibitor, 2-methylpiperazine dihydrochloride (H-7) suppressed the up-regulation of PMA-induced promoter activity and this effect decreased in a time-dependent manner.	Tetradecanoylphorbol Acetate	33-36	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	92-97
21174945-4	2010	Phorbol 12-myristate 13-acetate (PMA) is known as PKC activator, significantly enhanced the c-mpl promoter activity and PKC inhibitor, 2-methylpiperazine dihydrochloride (H-7) suppressed the up-regulation of PMA-induced promoter activity and this effect decreased in a time-dependent manner.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	120-123
20870937-12	2010	Our results support a model in which PMA stimulation activates PKCbetaI to phosphorylate NF90-Ser(647), and this phosphorylation triggers NF90 relocation to the cytoplasm and stabilize IL-2 mRNA.	Tetradecanoylphorbol Acetate	37-40	interleukin 2	Homo sapiens	185-189
20670683-5	2010	NCX (1 nM-50 muM) dose-dependently inhibited phorbol 12-myristate 13-acetate (PMA)-induced TNF-alpha release from monocytes (IC(50)=240 nM) and MDM (IC(50)=52 nM).	Tetradecanoylphorbol Acetate	78-81	latexin	Homo sapiens	13-16
20670683-5	2010	NCX (1 nM-50 muM) dose-dependently inhibited phorbol 12-myristate 13-acetate (PMA)-induced TNF-alpha release from monocytes (IC(50)=240 nM) and MDM (IC(50)=52 nM).	Tetradecanoylphorbol Acetate	78-81	tumor necrosis factor	Homo sapiens	91-100
20670683-8	2010	Likewise, NCX was more effective than pravastatin and the other NO donors in inhibiting PMA-induced NF-kappaB translocation in both cell types, and, at the highest concentration, significantly (P&lt;0.05) enhanced PPARgamma protein expression in monocytes.	Tetradecanoylphorbol Acetate	88-91	peroxisome proliferator activated receptor gamma	Homo sapiens	214-223
20670683-5	2010	NCX (1 nM-50 muM) dose-dependently inhibited phorbol 12-myristate 13-acetate (PMA)-induced TNF-alpha release from monocytes (IC(50)=240 nM) and MDM (IC(50)=52 nM).	Tetradecanoylphorbol Acetate	45-76	tumor necrosis factor	Homo sapiens	91-100
20976134-0	2010	Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells.	Tetradecanoylphorbol Acetate	69-72	tumor protein p53	Homo sapiens	34-37
20945045-2	2010	THP-1 monocytes were induced into macrophages by 160 nmol/L phorbol myristate acetate (PMA) for 48 h, and then the macrophages were exposed to visfatin and PPARgamma activator rosiglitazone, respectively.	Tetradecanoylphorbol Acetate	60-85	GLI family zinc finger 2	Homo sapiens	0-5
20945045-2	2010	THP-1 monocytes were induced into macrophages by 160 nmol/L phorbol myristate acetate (PMA) for 48 h, and then the macrophages were exposed to visfatin and PPARgamma activator rosiglitazone, respectively.	Tetradecanoylphorbol Acetate	87-90	GLI family zinc finger 2	Homo sapiens	0-5
20866083-3	2010	It is proposed that benzoic acid and water compete for the available sixth site on the [(TPA)Fe(III)(OOH)] intermediate, which undergoes O-O bond heterolysis to form, respectively, the Fe(V)(O)(O(2)CAr) and Fe(V)(O)(OH) oxidants that determine the product outcome.	Tetradecanoylphorbol Acetate	89-92	FEV transcription factor, ETS family member	Homo sapiens	185-190
20866083-3	2010	It is proposed that benzoic acid and water compete for the available sixth site on the [(TPA)Fe(III)(OOH)] intermediate, which undergoes O-O bond heterolysis to form, respectively, the Fe(V)(O)(O(2)CAr) and Fe(V)(O)(OH) oxidants that determine the product outcome.	Tetradecanoylphorbol Acetate	89-92	FEV transcription factor, ETS family member	Homo sapiens	207-212
20976134-5	2010	Our results showed that mitochondrial uncoupling blocked p53 mitochondrial translocation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA), a known tumor promoter to induce p53-mediated apoptosis in skin carcinogenesis.	Tetradecanoylphorbol Acetate	100-136	tumor protein p53	Homo sapiens	57-60
20976134-5	2010	Our results showed that mitochondrial uncoupling blocked p53 mitochondrial translocation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA), a known tumor promoter to induce p53-mediated apoptosis in skin carcinogenesis.	Tetradecanoylphorbol Acetate	100-136	tumor protein p53	Homo sapiens	177-180
20976134-5	2010	Our results showed that mitochondrial uncoupling blocked p53 mitochondrial translocation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA), a known tumor promoter to induce p53-mediated apoptosis in skin carcinogenesis.	Tetradecanoylphorbol Acetate	138-141	tumor protein p53	Homo sapiens	57-60
20976134-5	2010	Our results showed that mitochondrial uncoupling blocked p53 mitochondrial translocation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA), a known tumor promoter to induce p53-mediated apoptosis in skin carcinogenesis.	Tetradecanoylphorbol Acetate	138-141	tumor protein p53	Homo sapiens	177-180
20923549-4	2010	In order to decipher the mode of Rage function on gene transcription levels during inflammation, we applied global gene expression profiling on time-resolved samples of mouse back skin, which had been treated with the phorbol ester TPA, a potent inducer of skin inflammation.	Tetradecanoylphorbol Acetate	232-235	advanced glycosylation end product-specific receptor	Mus musculus	33-37
20696763-7	2010	ERK1/2 are also activated in most cells by phorbol 12-myristate 13-acetate, a classical inhibitor of agrin-induced AChR clustering in myotubes.	Tetradecanoylphorbol Acetate	43-74	mitogen-activated protein kinase 3	Homo sapiens	0-6
20876802-7	2010	Conversely, exogenous RasGRP3 elevated Ras-GTP, stimulated proliferation, and provided resistance to phorbol 12-myristate 13-acetate-induced apoptosis in LNCaP cells.	Tetradecanoylphorbol Acetate	101-132	RAS guanyl releasing protein 3	Homo sapiens	22-29
20691240-0	2010	The dietary flavonoid apigenin blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines.	Tetradecanoylphorbol Acetate	38-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
20878014-4	2010	However, when neutrophils were stimulated by receptor-bypassing phorbol 12-myristate 13-acetate (PMA), gangliosides above their critical micellar concentrations prolonged the lag time preceding the production in a concentration-dependent way, without affecting total extracellular O2 - generation detected by superoxide dismutase-inhibitable cytochrome c reduction.	Tetradecanoylphorbol Acetate	97-100	cytochrome c, somatic	Homo sapiens	342-354
20726989-10	2010	Upon stimulation with phorbol myristate acetate plus ionomycin, splenocytes from alpha-GalCer-treated mice produced significantly more cytokines [including IFN-gamma, tumour necrosis factor-alpha, IL-4 and IL-10] than those from untreated mice.	Tetradecanoylphorbol Acetate	22-47	interferon gamma	Mus musculus	156-195
20726989-10	2010	Upon stimulation with phorbol myristate acetate plus ionomycin, splenocytes from alpha-GalCer-treated mice produced significantly more cytokines [including IFN-gamma, tumour necrosis factor-alpha, IL-4 and IL-10] than those from untreated mice.	Tetradecanoylphorbol Acetate	22-47	interleukin 10	Mus musculus	206-211
20810567-0	2010	Differential role of PKC isoforms in GnRH and phorbol 12-myristate 13-acetate activation of extracellular signal-regulated kinase and Jun N-terminal kinase.	Tetradecanoylphorbol Acetate	46-77	protein kinase C, alpha	Mus musculus	21-24
20810567-7	2010	Interestingly, PKCalpha, PKCbetaII, and PKCepsilon translocation to the plasma membrane was more pronounced and more prolonged in phorbol-12-myristate-13-acetate (PMA) than in GnRH-treated cells.	Tetradecanoylphorbol Acetate	130-161	protein kinase C, alpha	Mus musculus	15-23
20810567-7	2010	Interestingly, PKCalpha, PKCbetaII, and PKCepsilon translocation to the plasma membrane was more pronounced and more prolonged in phorbol-12-myristate-13-acetate (PMA) than in GnRH-treated cells.	Tetradecanoylphorbol Acetate	163-166	protein kinase C, alpha	Mus musculus	15-23
20691240-5	2010	Real-time PCR and/or Western blotting indicated that APG in micromolar range significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in these breast cells.	Tetradecanoylphorbol Acetate	101-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
20691240-5	2010	Real-time PCR and/or Western blotting indicated that APG in micromolar range significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in these breast cells.	Tetradecanoylphorbol Acetate	134-137	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152
20524209-3	2010	We wanted to examine whether Phorbol 12-myristate 13-acetate (PMA), one of PKC activators, treatment of the airway epithelial cell line NCI-H292 increases lysozyme gene expression.	Tetradecanoylphorbol Acetate	29-60	lysozyme	Homo sapiens	155-163
20524209-3	2010	We wanted to examine whether Phorbol 12-myristate 13-acetate (PMA), one of PKC activators, treatment of the airway epithelial cell line NCI-H292 increases lysozyme gene expression.	Tetradecanoylphorbol Acetate	62-65	lysozyme	Homo sapiens	155-163
20524209-5	2010	We found that PKC and mitogen-activating protein/ERK2 kinase are essential for PMA-induced lysozyme expression and also mediate the PMA-induced activation of c-Myb protein.	Tetradecanoylphorbol Acetate	79-82	mitogen-activated protein kinase 1	Homo sapiens	49-53
20524209-5	2010	We found that PKC and mitogen-activating protein/ERK2 kinase are essential for PMA-induced lysozyme expression and also mediate the PMA-induced activation of c-Myb protein.	Tetradecanoylphorbol Acetate	79-82	lysozyme	Homo sapiens	91-99
20524209-5	2010	We found that PKC and mitogen-activating protein/ERK2 kinase are essential for PMA-induced lysozyme expression and also mediate the PMA-induced activation of c-Myb protein.	Tetradecanoylphorbol Acetate	132-135	mitogen-activated protein kinase 1	Homo sapiens	49-53
20524209-9	2010	From these results, we conclude that PMA induces overexpression of lysozyme via ERK1/2 MAP kinase-c-Myb signaling pathways in NCI-H292 cells.	Tetradecanoylphorbol Acetate	37-40	lysozyme	Homo sapiens	67-75
20354949-7	2010	Moreover, acteoside inhibited histamine release, TNF- alpha, and IL-4 production in a dose-dependent manner from calcium ionophore A23187 plus phorbol 12-myristate 13-acetate (PMA) or compound 48/80-stimulated KU812 cells.	Tetradecanoylphorbol Acetate	176-179	interleukin 4	Homo sapiens	65-69
20860439-7	2010	Further, we have investigated the effect of glycyrol on phorbol 12-myristate 13-acetate (PMA)/ionomycin (Io)-stimulated IL-2 expression in Jurkat cells.	Tetradecanoylphorbol Acetate	56-87	interleukin 2	Homo sapiens	120-124
20860439-7	2010	Further, we have investigated the effect of glycyrol on phorbol 12-myristate 13-acetate (PMA)/ionomycin (Io)-stimulated IL-2 expression in Jurkat cells.	Tetradecanoylphorbol Acetate	89-92	interleukin 2	Homo sapiens	120-124
20731354-4	2010	Topical application of TPA to ears of CD-1 mice induced inflammation accompanied with substantial increase in TNF-alpha, IL-1beta, IL-6, LTB4, and PGE2 levels and an elevation in intercellular adhesion molecule-1 (ICAM-1) gene expressions in ear skin tissues.	Tetradecanoylphorbol Acetate	23-26	tumor necrosis factor	Mus musculus	110-119
20851349-6	2010	The activity correlated well with processing of prointerleukin-1beta and prointerleukin-18 in phorbol 12-myristate 13-acetate (PMA)-stimulated cells.	Tetradecanoylphorbol Acetate	94-125	interleukin 1 beta	Homo sapiens	48-68
20851349-6	2010	The activity correlated well with processing of prointerleukin-1beta and prointerleukin-18 in phorbol 12-myristate 13-acetate (PMA)-stimulated cells.	Tetradecanoylphorbol Acetate	127-130	interleukin 1 beta	Homo sapiens	48-68
20696233-7	2010	Furthermore, butein repressed the expression of VEGF and MMP-9 induced by treatment with tumor necrosis factor-alpha and phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	121-152	vascular endothelial growth factor A	Homo sapiens	48-52
20875097-8	2010	The bradykinin effect on resensitization was similar in the absence of extracellular Ca2+ or in the presence of the PKC activator PMA, but was inhibited by the protein phosphatase inhibitor okadaic acid and the PI3K inhibitor LY294002.	Tetradecanoylphorbol Acetate	130-133	kininogen 1	Homo sapiens	4-14
20731354-4	2010	Topical application of TPA to ears of CD-1 mice induced inflammation accompanied with substantial increase in TNF-alpha, IL-1beta, IL-6, LTB4, and PGE2 levels and an elevation in intercellular adhesion molecule-1 (ICAM-1) gene expressions in ear skin tissues.	Tetradecanoylphorbol Acetate	23-26	interleukin 1 beta	Mus musculus	121-129
20731354-4	2010	Topical application of TPA to ears of CD-1 mice induced inflammation accompanied with substantial increase in TNF-alpha, IL-1beta, IL-6, LTB4, and PGE2 levels and an elevation in intercellular adhesion molecule-1 (ICAM-1) gene expressions in ear skin tissues.	Tetradecanoylphorbol Acetate	23-26	interleukin 6	Mus musculus	131-135
20736304-7	2010	Conversely, 12-O-tetradecanoylphorbol-13-acetate, which activates ERK1/2, enhanced SOCE in cells expressing wild-type tagged STIM1, but did not potentiate Ca2+ influx in cells expressing serine to alanine mutations in ERK1/2 target sites of STIM1.	Tetradecanoylphorbol Acetate	12-48	mitogen-activated protein kinase 3	Homo sapiens	66-72
20541543-6	2010	Moreover, palmitate treatment induced activation of protein kinase Ctheta (PKCtheta) while blocking PKCtheta significantly inhibited JNK and IKKbeta activation induced by palmitate or phorbol 12-myristate 13-acetate (PKC activator, PMA), and attenuated the palmitate-induced defects in insulin action.	Tetradecanoylphorbol Acetate	184-215	protein kinase C theta	Homo sapiens	100-108
20541543-6	2010	Moreover, palmitate treatment induced activation of protein kinase Ctheta (PKCtheta) while blocking PKCtheta significantly inhibited JNK and IKKbeta activation induced by palmitate or phorbol 12-myristate 13-acetate (PKC activator, PMA), and attenuated the palmitate-induced defects in insulin action.	Tetradecanoylphorbol Acetate	184-215	mitogen-activated protein kinase 8	Homo sapiens	133-136
20541543-6	2010	Moreover, palmitate treatment induced activation of protein kinase Ctheta (PKCtheta) while blocking PKCtheta significantly inhibited JNK and IKKbeta activation induced by palmitate or phorbol 12-myristate 13-acetate (PKC activator, PMA), and attenuated the palmitate-induced defects in insulin action.	Tetradecanoylphorbol Acetate	184-215	insulin	Homo sapiens	286-293
20541543-6	2010	Moreover, palmitate treatment induced activation of protein kinase Ctheta (PKCtheta) while blocking PKCtheta significantly inhibited JNK and IKKbeta activation induced by palmitate or phorbol 12-myristate 13-acetate (PKC activator, PMA), and attenuated the palmitate-induced defects in insulin action.	Tetradecanoylphorbol Acetate	232-235	protein kinase C theta	Homo sapiens	100-108
20736304-7	2010	Conversely, 12-O-tetradecanoylphorbol-13-acetate, which activates ERK1/2, enhanced SOCE in cells expressing wild-type tagged STIM1, but did not potentiate Ca2+ influx in cells expressing serine to alanine mutations in ERK1/2 target sites of STIM1.	Tetradecanoylphorbol Acetate	12-48	stromal interaction molecule 1	Homo sapiens	125-130
20736304-7	2010	Conversely, 12-O-tetradecanoylphorbol-13-acetate, which activates ERK1/2, enhanced SOCE in cells expressing wild-type tagged STIM1, but did not potentiate Ca2+ influx in cells expressing serine to alanine mutations in ERK1/2 target sites of STIM1.	Tetradecanoylphorbol Acetate	12-48	stromal interaction molecule 1	Homo sapiens	241-246
20800788-8	2010	Twenty-six patients with PMA (84%) and 12 without PMA (43%) had total IgE values greater than 100 kU/L (P=.001).	Tetradecanoylphorbol Acetate	25-28	immunoglobulin heavy constant epsilon	Homo sapiens	70-73
20673574-2	2010	Changes in the inflammatory profiles of lipopolysaccharide (LPS)-stimulated phrobol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophage models were investigated following pGlc treatment.	Tetradecanoylphorbol Acetate	109-112	GLI family zinc finger 2	Homo sapiens	129-134
20800788-8	2010	Twenty-six patients with PMA (84%) and 12 without PMA (43%) had total IgE values greater than 100 kU/L (P=.001).	Tetradecanoylphorbol Acetate	50-53	immunoglobulin heavy constant epsilon	Homo sapiens	70-73
20660715-3	2010	Here, we report that capsaicin has a cocarcinogenic effect on 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis in vivo and is mediated through the epidermal growth factor receptor (EGFR), but not the transient receptor potential vanilloid subfamily member 1 (TRPV1).	Tetradecanoylphorbol Acetate	62-98	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	282-287
20652762-0	2010	Alpha-mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells.	Tetradecanoylphorbol Acetate	27-58	mitogen-activated protein kinase 1	Homo sapiens	120-123
20652762-0	2010	Alpha-mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells.	Tetradecanoylphorbol Acetate	27-58	nuclear factor kappa B subunit 1	Homo sapiens	128-137
20471435-3	2010	The tumor promoter 12-O-tetradecanoylphorbor-13-acetate (TPA), a protein kinase C stimulator, inhibits TGF-beta1-induced apoptosis.	Tetradecanoylphorbol Acetate	57-60	transforming growth factor beta 1	Homo sapiens	103-112
19747856-4	2010	METHODS: After 48 h of culture in the presence of phorbol myristate acetate, THP-1 monocytes differentiated to macrophages.	Tetradecanoylphorbol Acetate	50-75	GLI family zinc finger 2	Homo sapiens	77-82
20660715-8	2010	TPA/capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR/WT, but not EGFR/KO cells.	Tetradecanoylphorbol Acetate	0-3	thymoma viral proto-oncogene 1	Mus musculus	123-126
20660715-3	2010	Here, we report that capsaicin has a cocarcinogenic effect on 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis in vivo and is mediated through the epidermal growth factor receptor (EGFR), but not the transient receptor potential vanilloid subfamily member 1 (TRPV1).	Tetradecanoylphorbol Acetate	100-103	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	282-287
20660715-4	2010	Topical application of capsaicin on the dorsal skin of 7,12-dimetylbenz(a)anthracene-initiated and TPA-promoted TRPV1 wild-type (WT) and TRPV1 knockout (KO) mice induced more and larger skin tumors in TRPV1/KO mice, suggesting a TRPV1-independent mechanism.	Tetradecanoylphorbol Acetate	99-102	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	112-117
20660715-4	2010	Topical application of capsaicin on the dorsal skin of 7,12-dimetylbenz(a)anthracene-initiated and TPA-promoted TRPV1 wild-type (WT) and TRPV1 knockout (KO) mice induced more and larger skin tumors in TRPV1/KO mice, suggesting a TRPV1-independent mechanism.	Tetradecanoylphorbol Acetate	99-102	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	137-142
20660715-4	2010	Topical application of capsaicin on the dorsal skin of 7,12-dimetylbenz(a)anthracene-initiated and TPA-promoted TRPV1 wild-type (WT) and TRPV1 knockout (KO) mice induced more and larger skin tumors in TRPV1/KO mice, suggesting a TRPV1-independent mechanism.	Tetradecanoylphorbol Acetate	99-102	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	137-142
20660715-4	2010	Topical application of capsaicin on the dorsal skin of 7,12-dimetylbenz(a)anthracene-initiated and TPA-promoted TRPV1 wild-type (WT) and TRPV1 knockout (KO) mice induced more and larger skin tumors in TRPV1/KO mice, suggesting a TRPV1-independent mechanism.	Tetradecanoylphorbol Acetate	99-102	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	137-142
20660715-6	2010	Inhibitors of EGFR/MEK signaling suppressed TPA/capsaicin-induced COX-2 expression in TRPV1/KO cells, indicating that activation of EGFR and its downstream signaling is involved in COX-2 elevation.	Tetradecanoylphorbol Acetate	44-47	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	86-91
20471972-10	2010	Different concentration PMA enhanced TIMP-1 mRNA expression, but IL-1beta did not affect the TIMP-1 mRNA expression.	Tetradecanoylphorbol Acetate	24-27	TIMP metallopeptidase inhibitor 1	Homo sapiens	37-43
20336681-3	2010	We demonstrate that topical application of 6-shogaol more effectively inhibited 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated transcription of iNOS and COX-2 mRNA expression in mouse skin than curcumin and 6-gingerol.	Tetradecanoylphorbol Acetate	80-116	nitric oxide synthase 2, inducible	Mus musculus	151-155
20336681-6	2010	Moreover, 6-shogaol markedly suppressed TPA-induced activation of extracellular signal-regulate kinase1/2, p38 mitogen-activated protein kinase, JNK1/2, and phosphatidylinositol 3-kinase/Akt, which are upstream of nuclear factor-kappaB and AP-1.	Tetradecanoylphorbol Acetate	40-43	thymoma viral proto-oncogene 1	Mus musculus	187-190
20336681-3	2010	We demonstrate that topical application of 6-shogaol more effectively inhibited 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated transcription of iNOS and COX-2 mRNA expression in mouse skin than curcumin and 6-gingerol.	Tetradecanoylphorbol Acetate	118-121	nitric oxide synthase 2, inducible	Mus musculus	151-155
20336681-5	2010	6-Shogaol also reduced TPA-induced phosphorylation of IkappaBalpha and p65, and caused subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	23-26	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	54-66
20417648-7	2010	Thrombin also decreased TER after depletion of conventional and novel Ca(2+)-dependent PKC isoforms using phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	106-137	coagulation factor II, thrombin	Homo sapiens	0-8
20564234-7	2010	We demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment of the airway epithelial cell line NCI-H292 increases MUC8 gene and AP2 alpha expression.	Tetradecanoylphorbol Acetate	21-52	mucin 8	Homo sapiens	123-127
20417648-7	2010	Thrombin also decreased TER after depletion of conventional and novel Ca(2+)-dependent PKC isoforms using phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	139-142	coagulation factor II, thrombin	Homo sapiens	0-8
20607724-4	2010	12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed expression of pdcd4 mRNA in human monocytic cell lines (U937, THP-1).	Tetradecanoylphorbol Acetate	0-36	GLI family zinc finger 2	Homo sapiens	116-121
20607724-4	2010	12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed expression of pdcd4 mRNA in human monocytic cell lines (U937, THP-1).	Tetradecanoylphorbol Acetate	38-41	GLI family zinc finger 2	Homo sapiens	116-121
20554528-2	2010	MCF-7 human breast carcinoma cells treated with the phorbol 12-myristate 13-acetate (PMA) suffer growth arrest and show morphological alterations, which depend on the activation of the ERK1/2 MAP kinases.	Tetradecanoylphorbol Acetate	52-83	mitogen-activated protein kinase 3	Homo sapiens	185-191
20554528-2	2010	MCF-7 human breast carcinoma cells treated with the phorbol 12-myristate 13-acetate (PMA) suffer growth arrest and show morphological alterations, which depend on the activation of the ERK1/2 MAP kinases.	Tetradecanoylphorbol Acetate	85-88	mitogen-activated protein kinase 3	Homo sapiens	185-191
20564234-7	2010	We demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment of the airway epithelial cell line NCI-H292 increases MUC8 gene and AP2 alpha expression.	Tetradecanoylphorbol Acetate	54-57	mucin 8	Homo sapiens	123-127
20564234-15	2010	From these results, we concluded that PMA induces MUC8 gene expression through a mechanism involving PKC, ERK1/2, and AP2 alpha activation in human airway epithelial cells.	Tetradecanoylphorbol Acetate	38-41	mucin 8	Homo sapiens	50-54
20564234-15	2010	From these results, we concluded that PMA induces MUC8 gene expression through a mechanism involving PKC, ERK1/2, and AP2 alpha activation in human airway epithelial cells.	Tetradecanoylphorbol Acetate	38-41	proline rich transmembrane protein 2	Homo sapiens	101-104
20582552-4	2010	Phorbol 12-myristate 13-acetate (PMA) treatment for 5637 bladder cancer cells increased COX-2 expression, slightly induced Slug expression, and decreased E-cadherin expression.	Tetradecanoylphorbol Acetate	0-31	prostaglandin-endoperoxide synthase 2	Homo sapiens	88-93
20582552-4	2010	Phorbol 12-myristate 13-acetate (PMA) treatment for 5637 bladder cancer cells increased COX-2 expression, slightly induced Slug expression, and decreased E-cadherin expression.	Tetradecanoylphorbol Acetate	0-31	cadherin 1	Homo sapiens	154-164
20582552-4	2010	Phorbol 12-myristate 13-acetate (PMA) treatment for 5637 bladder cancer cells increased COX-2 expression, slightly induced Slug expression, and decreased E-cadherin expression.	Tetradecanoylphorbol Acetate	33-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	88-93
20582552-4	2010	Phorbol 12-myristate 13-acetate (PMA) treatment for 5637 bladder cancer cells increased COX-2 expression, slightly induced Slug expression, and decreased E-cadherin expression.	Tetradecanoylphorbol Acetate	33-36	cadherin 1	Homo sapiens	154-164
20576605-5	2010	Crotepoxide inhibition of NF-kappaB was not inducer-specific; it inhibited NF-kappaB activation induced by TNF, phorbol 12-myristate 13-acetate, lipopolysaccharide, and cigarette smoke.	Tetradecanoylphorbol Acetate	112-143	nuclear factor kappa B subunit 1	Homo sapiens	75-84
20564234-15	2010	From these results, we concluded that PMA induces MUC8 gene expression through a mechanism involving PKC, ERK1/2, and AP2 alpha activation in human airway epithelial cells.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase 3	Homo sapiens	106-112
20566751-7	2010	Furthermore, a PKC-delta inhibitor, rottlerin, prevented up-regulation of claudin-7, occludin, ZO-1, and ZO-2 by TPA.	Tetradecanoylphorbol Acetate	113-116	tight junction protein 1	Homo sapiens	95-99
20566751-6	2010	A PKC-alpha inhibitor, Go6976, prevented up-regulation of claudin-4 by TPA.	Tetradecanoylphorbol Acetate	71-74	claudin 4	Homo sapiens	58-67
20584749-8	2010	In support of this speculation, the reducing agent dithiothreitol abrogated the inhibitory effects of PIC on TPA-induced activation of NF-kappaB signaling and expression of COX-2.	Tetradecanoylphorbol Acetate	109-112	prostaglandin-endoperoxide synthase 2	Homo sapiens	173-178
20508956-8	2010	Most of the syncytia were viable and expressed CD25 and IL-2 in response to activation by phorbol myristate acetate (PMA) and ionomicyn.	Tetradecanoylphorbol Acetate	90-115	interleukin 2	Homo sapiens	56-60
20508956-8	2010	Most of the syncytia were viable and expressed CD25 and IL-2 in response to activation by phorbol myristate acetate (PMA) and ionomicyn.	Tetradecanoylphorbol Acetate	117-120	interleukin 2	Homo sapiens	56-60
20584749-6	2010	PIC treatment suppressed the TPA-induced activation of NF-kappaB and expression of cyclooxygenase-2 (COX-2) in MCF-10A cells.	Tetradecanoylphorbol Acetate	29-32	nuclear factor kappa B subunit 1	Homo sapiens	55-64
20584749-10	2010	In conclusion, our results show that direct modification of IKKbeta by PIC, presumably at the cysteine 179 residue, blocks NF-kappaB activation signaling and COX-2 induction in TPA-treated MCF-10A cells and also migration and transformation of these cells.	Tetradecanoylphorbol Acetate	177-180	nuclear factor kappa B subunit 1	Homo sapiens	123-132
20584749-6	2010	PIC treatment suppressed the TPA-induced activation of NF-kappaB and expression of cyclooxygenase-2 (COX-2) in MCF-10A cells.	Tetradecanoylphorbol Acetate	29-32	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-99
20584749-6	2010	PIC treatment suppressed the TPA-induced activation of NF-kappaB and expression of cyclooxygenase-2 (COX-2) in MCF-10A cells.	Tetradecanoylphorbol Acetate	29-32	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-106
20584749-10	2010	In conclusion, our results show that direct modification of IKKbeta by PIC, presumably at the cysteine 179 residue, blocks NF-kappaB activation signaling and COX-2 induction in TPA-treated MCF-10A cells and also migration and transformation of these cells.	Tetradecanoylphorbol Acetate	177-180	prostaglandin-endoperoxide synthase 2	Homo sapiens	158-163
20584749-8	2010	In support of this speculation, the reducing agent dithiothreitol abrogated the inhibitory effects of PIC on TPA-induced activation of NF-kappaB signaling and expression of COX-2.	Tetradecanoylphorbol Acetate	109-112	nuclear factor kappa B subunit 1	Homo sapiens	135-144
20452384-5	2010	Tumor necrosis factor (TNF)-alpha repressed the expression of ACE in HUVECs while phorbol 12-myristate 13-acetate (PMA) upregulated it in 24h (approximately 12-fold dynamic range by [(3)H]enalaprilat binding, corroborated by ACE immunoblotting).	Tetradecanoylphorbol Acetate	82-113	angiotensin I converting enzyme	Homo sapiens	225-228
20445555-4	2010	In this study, we use small interfering RNA knockdown to study the role of individual PKC isoforms as regulators of keratinocyte differentiation induced by the potent differentiating stimulus, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	193-229	protein kinase C alpha	Homo sapiens	86-89
20445555-4	2010	In this study, we use small interfering RNA knockdown to study the role of individual PKC isoforms as regulators of keratinocyte differentiation induced by the potent differentiating stimulus, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	231-234	protein kinase C alpha	Homo sapiens	86-89
20592496-8	2010	Additionally, treatment with As(2)O(3) in combination with inhibitors specific for MEK (U0126) in HOS and MNNG cells resulted in a marked inhibition of cell invasion and As(2)O(3) could significantly reduce PMA-induced invasion.	Tetradecanoylphorbol Acetate	207-210	mitogen-activated protein kinase kinase 7	Homo sapiens	83-86
20455898-5	2010	CCR8 expression on IFN-gamma+ and IL-4+/IL-13+ blood and BAL T cells was studied following stimulation with Phorbol-Myristate-Acetate and Calcium Ionophore.	Tetradecanoylphorbol Acetate	108-133	C-C motif chemokine receptor 8	Homo sapiens	0-4
20512034-11	2010	Phosphorylation levels induced by interleukin-6 in STAT1 and STAT3 and by combination of phorbol 12-myristate 13-acetate and calcium ionophore A23187 in extracellular signal-regulated kinases 1/2, members of a mitogen-activated protein kinase family, were depressed in patients" monocytes, whereas phosphorylation levels induced by granulocyte-macrophage colony-stimulating factor in STAT5 was normal.	Tetradecanoylphorbol Acetate	89-120	interleukin 6	Homo sapiens	34-47
20512034-11	2010	Phosphorylation levels induced by interleukin-6 in STAT1 and STAT3 and by combination of phorbol 12-myristate 13-acetate and calcium ionophore A23187 in extracellular signal-regulated kinases 1/2, members of a mitogen-activated protein kinase family, were depressed in patients" monocytes, whereas phosphorylation levels induced by granulocyte-macrophage colony-stimulating factor in STAT5 was normal.	Tetradecanoylphorbol Acetate	89-120	mitogen-activated protein kinase 3	Homo sapiens	153-195
20452384-5	2010	Tumor necrosis factor (TNF)-alpha repressed the expression of ACE in HUVECs while phorbol 12-myristate 13-acetate (PMA) upregulated it in 24h (approximately 12-fold dynamic range by [(3)H]enalaprilat binding, corroborated by ACE immunoblotting).	Tetradecanoylphorbol Acetate	115-118	angiotensin I converting enzyme	Homo sapiens	225-228
19761816-6	2010	Activation of PKC with either phorbol 12-myristate 13-acetate or thrombin enhanced AQP4 phosphorylation, reduced water permeability and significantly decreased cell invasion.	Tetradecanoylphorbol Acetate	30-61	proline rich transmembrane protein 2	Homo sapiens	14-17
20673182-10	2010	Furthermore, PMC exhibited obvious inhibitory effects on phorbol 12-myristate 13-acetate (PMA)-induced protein kinase C (PKC)-alpha translocation and phospho-(Ser/Thr) substrate phosphorylation.	Tetradecanoylphorbol Acetate	57-88	protein kinase C alpha	Homo sapiens	121-131
20673182-10	2010	Furthermore, PMC exhibited obvious inhibitory effects on phorbol 12-myristate 13-acetate (PMA)-induced protein kinase C (PKC)-alpha translocation and phospho-(Ser/Thr) substrate phosphorylation.	Tetradecanoylphorbol Acetate	90-93	protein kinase C alpha	Homo sapiens	121-131
20501791-7	2010	Induction of TACE/ADAM17 by the phorbol-ester phorbol 12-myristate 13-acetate (PMA) induced germ cell apoptosis, which was prevented when an inhibitor of TACE/ADAM17 was present in the assay.	Tetradecanoylphorbol Acetate	46-77	ADAM metallopeptidase domain 17	Rattus norvegicus	13-17
20501791-7	2010	Induction of TACE/ADAM17 by the phorbol-ester phorbol 12-myristate 13-acetate (PMA) induced germ cell apoptosis, which was prevented when an inhibitor of TACE/ADAM17 was present in the assay.	Tetradecanoylphorbol Acetate	46-77	ADAM metallopeptidase domain 17	Rattus norvegicus	18-24
20501791-7	2010	Induction of TACE/ADAM17 by the phorbol-ester phorbol 12-myristate 13-acetate (PMA) induced germ cell apoptosis, which was prevented when an inhibitor of TACE/ADAM17 was present in the assay.	Tetradecanoylphorbol Acetate	46-77	ADAM metallopeptidase domain 17	Rattus norvegicus	154-158
20501791-7	2010	Induction of TACE/ADAM17 by the phorbol-ester phorbol 12-myristate 13-acetate (PMA) induced germ cell apoptosis, which was prevented when an inhibitor of TACE/ADAM17 was present in the assay.	Tetradecanoylphorbol Acetate	46-77	ADAM metallopeptidase domain 17	Rattus norvegicus	159-165
20501791-7	2010	Induction of TACE/ADAM17 by the phorbol-ester phorbol 12-myristate 13-acetate (PMA) induced germ cell apoptosis, which was prevented when an inhibitor of TACE/ADAM17 was present in the assay.	Tetradecanoylphorbol Acetate	79-82	ADAM metallopeptidase domain 17	Rattus norvegicus	13-17
20501791-7	2010	Induction of TACE/ADAM17 by the phorbol-ester phorbol 12-myristate 13-acetate (PMA) induced germ cell apoptosis, which was prevented when an inhibitor of TACE/ADAM17 was present in the assay.	Tetradecanoylphorbol Acetate	79-82	ADAM metallopeptidase domain 17	Rattus norvegicus	18-24
20501791-7	2010	Induction of TACE/ADAM17 by the phorbol-ester phorbol 12-myristate 13-acetate (PMA) induced germ cell apoptosis, which was prevented when an inhibitor of TACE/ADAM17 was present in the assay.	Tetradecanoylphorbol Acetate	79-82	ADAM metallopeptidase domain 17	Rattus norvegicus	154-158
20501791-7	2010	Induction of TACE/ADAM17 by the phorbol-ester phorbol 12-myristate 13-acetate (PMA) induced germ cell apoptosis, which was prevented when an inhibitor of TACE/ADAM17 was present in the assay.	Tetradecanoylphorbol Acetate	79-82	ADAM metallopeptidase domain 17	Rattus norvegicus	159-165
20479004-6	2010	Pin1(-/-) mouse embryonic fibroblasts showed lower 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MEK1/2 phosphorylation than Pin1(+/+) mouse embryonic fibroblasts.	Tetradecanoylphorbol Acetate	51-87	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
20479004-6	2010	Pin1(-/-) mouse embryonic fibroblasts showed lower 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MEK1/2 phosphorylation than Pin1(+/+) mouse embryonic fibroblasts.	Tetradecanoylphorbol Acetate	89-92	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	0-4
20979792-2	2010	METHODS: LDL from healthy volunteers was obtained by density-gradient ultracentrifugation and was oxidized by incubation with Cu2+ and ox-LDL was identified.Macrophages were induced from THP-1 cell by phorbol ester (PMA).	Tetradecanoylphorbol Acetate	216-219	GLI family zinc finger 2	Homo sapiens	187-192
20669099-12	2010	PMA-induced cell death occurred if the phospho-NF-kappaB/p65 was prohibited from entering the nucleus in PKC delta positive cells.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	47-56
20558134-2	2010	The proteins on the surface of EA.hy926 cells were labelled with EZ-Link NHS-SS-Biotin both prior to (control) and following stimulation by 2 microM phorbol 12-myristate 13-acetate (PMA) which activates PKC.	Tetradecanoylphorbol Acetate	149-180	proline rich transmembrane protein 2	Homo sapiens	203-206
20550117-7	2010	The EEGC also showed an inhibitory effect on the PMA-induced phosphorylation of extracellular signal-regulated kinase (ERK1/2) and protein kinase B (Akt) in cytosol, as well as the activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) levels in the nucleus of HepG2 cells.	Tetradecanoylphorbol Acetate	49-52	mitogen-activated protein kinase 3	Homo sapiens	119-125
20550117-7	2010	The EEGC also showed an inhibitory effect on the PMA-induced phosphorylation of extracellular signal-regulated kinase (ERK1/2) and protein kinase B (Akt) in cytosol, as well as the activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) levels in the nucleus of HepG2 cells.	Tetradecanoylphorbol Acetate	49-52	AKT serine/threonine kinase 1	Homo sapiens	149-152
20550117-7	2010	The EEGC also showed an inhibitory effect on the PMA-induced phosphorylation of extracellular signal-regulated kinase (ERK1/2) and protein kinase B (Akt) in cytosol, as well as the activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) levels in the nucleus of HepG2 cells.	Tetradecanoylphorbol Acetate	49-52	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	181-200
20550117-7	2010	The EEGC also showed an inhibitory effect on the PMA-induced phosphorylation of extracellular signal-regulated kinase (ERK1/2) and protein kinase B (Akt) in cytosol, as well as the activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) levels in the nucleus of HepG2 cells.	Tetradecanoylphorbol Acetate	49-52	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	202-206
20590612-0	2010	Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activator protein-1.	Tetradecanoylphorbol Acetate	174-205	mitogen-activated protein kinase 1	Homo sapiens	214-251
20590612-7	2010	In addition, metformin strongly repressed the PMA-induced phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and protein kinase C(PKC)alpha, whereas the phosphorylation of p38 mitogen-activated protein kinase was not affected by metformin.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 1	Homo sapiens	77-114
20590612-7	2010	In addition, metformin strongly repressed the PMA-induced phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and protein kinase C(PKC)alpha, whereas the phosphorylation of p38 mitogen-activated protein kinase was not affected by metformin.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 1	Homo sapiens	116-119
20590612-7	2010	In addition, metformin strongly repressed the PMA-induced phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and protein kinase C(PKC)alpha, whereas the phosphorylation of p38 mitogen-activated protein kinase was not affected by metformin.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 8	Homo sapiens	122-151
20590612-7	2010	In addition, metformin strongly repressed the PMA-induced phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and protein kinase C(PKC)alpha, whereas the phosphorylation of p38 mitogen-activated protein kinase was not affected by metformin.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 14	Homo sapiens	215-251
20590612-10	2010	CONCLUSIONS AND IMPLICATIONS: Metformin inhibited PMA-induced invasion and migration of human fibrosarcoma cells via Ca(2+)-dependent PKCalpha/ERK and JNK/AP-1-signalling pathways.	Tetradecanoylphorbol Acetate	50-53	protein kinase C alpha	Homo sapiens	134-142
20590612-10	2010	CONCLUSIONS AND IMPLICATIONS: Metformin inhibited PMA-induced invasion and migration of human fibrosarcoma cells via Ca(2+)-dependent PKCalpha/ERK and JNK/AP-1-signalling pathways.	Tetradecanoylphorbol Acetate	50-53	mitogen-activated protein kinase 1	Homo sapiens	143-146
20590612-10	2010	CONCLUSIONS AND IMPLICATIONS: Metformin inhibited PMA-induced invasion and migration of human fibrosarcoma cells via Ca(2+)-dependent PKCalpha/ERK and JNK/AP-1-signalling pathways.	Tetradecanoylphorbol Acetate	50-53	mitogen-activated protein kinase 8	Homo sapiens	151-154
20846475-3	2010	IL-2 production, in contrast, was strongly inhibited in both transfectant populations stimulated by PMA plus the calcium ionophore ionomycin.	Tetradecanoylphorbol Acetate	100-103	interleukin 2	Homo sapiens	0-4
19943262-0	2010	Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cdelta/p38 mitogen-activated protein kinase and JNK/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression.	Tetradecanoylphorbol Acetate	15-46	mitogen-activated protein kinase 14	Homo sapiens	134-137
19943262-7	2010	Furthermore, bergamottin strongly repressed the PMA-induced phosphorylation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase (JNK), which are dependent on the protein kinase C-delta pathway.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 14	Homo sapiens	79-82
20448034-5	2010	Phorbol 12-myristate 13-acetate-, thrombin-, or forskolin-induced von Willebrand factor release or translocation of P-selectin from endothelial cells were inhibited by alpha- and beta-synuclein but not gamma-synuclein.	Tetradecanoylphorbol Acetate	0-31	coagulation factor II, thrombin	Homo sapiens	34-42
20564344-5	2010	DIM inhibited the TPA-induced increases in the expression of cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), chemokine (C-X-C motif) ligand (CXCL) 5, and interleukin (IL)-6 in mouse skin.	Tetradecanoylphorbol Acetate	18-21	nitric oxide synthase 2, inducible	Mus musculus	85-116
20564344-5	2010	DIM inhibited the TPA-induced increases in the expression of cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), chemokine (C-X-C motif) ligand (CXCL) 5, and interleukin (IL)-6 in mouse skin.	Tetradecanoylphorbol Acetate	18-21	nitric oxide synthase 2, inducible	Mus musculus	118-122
20564344-5	2010	DIM inhibited the TPA-induced increases in the expression of cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), chemokine (C-X-C motif) ligand (CXCL) 5, and interleukin (IL)-6 in mouse skin.	Tetradecanoylphorbol Acetate	18-21	interleukin 6	Mus musculus	170-188
20564344-6	2010	DIM also inhibited nuclear factor-kappa B (NF-kappaB)"s DNA binding activity, the nuclear translocation of p65, and the degradation of inhibitor of kappaB (IkappaB) alpha in TPA-stimulated mouse skin.	Tetradecanoylphorbol Acetate	174-177	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	43-52
20514473-0	2010	Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by apigenin via the inhibition of p38 mitogen-activated protein kinase-dependent matrix metalloproteinase-9 expression.	Tetradecanoylphorbol Acetate	15-46	mitogen-activated protein kinase 14	Homo sapiens	109-112
20514473-6	2010	We found that apigenin could inhibit PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), which was involved in the down-regulation of the expression of matrix metalloproteinase-9 (MMP-9) at mRNA levels.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 14	Homo sapiens	68-104
20514473-6	2010	We found that apigenin could inhibit PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), which was involved in the down-regulation of the expression of matrix metalloproteinase-9 (MMP-9) at mRNA levels.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 14	Homo sapiens	106-114
20669099-3	2010	MATERIAL AND METHODS: The activation of NF-kappaB by PKC alpha and PKC delta was assessed by Western blotting after the stimulation with Phorbol 12- Myristate 13-Acetate (PMA).	Tetradecanoylphorbol Acetate	137-169	nuclear factor kappa B subunit 1	Homo sapiens	40-49
20669099-3	2010	MATERIAL AND METHODS: The activation of NF-kappaB by PKC alpha and PKC delta was assessed by Western blotting after the stimulation with Phorbol 12- Myristate 13-Acetate (PMA).	Tetradecanoylphorbol Acetate	137-169	protein kinase C alpha	Homo sapiens	53-62
20669099-3	2010	MATERIAL AND METHODS: The activation of NF-kappaB by PKC alpha and PKC delta was assessed by Western blotting after the stimulation with Phorbol 12- Myristate 13-Acetate (PMA).	Tetradecanoylphorbol Acetate	171-174	nuclear factor kappa B subunit 1	Homo sapiens	40-49
20669099-3	2010	MATERIAL AND METHODS: The activation of NF-kappaB by PKC alpha and PKC delta was assessed by Western blotting after the stimulation with Phorbol 12- Myristate 13-Acetate (PMA).	Tetradecanoylphorbol Acetate	171-174	protein kinase C alpha	Homo sapiens	53-62
20669099-5	2010	RESULTS: PMA induced the phosphorylation of NF-kappaB/p65 by PKC alpha.	Tetradecanoylphorbol Acetate	9-12	nuclear factor kappa B subunit 1	Homo sapiens	44-53
20669099-5	2010	RESULTS: PMA induced the phosphorylation of NF-kappaB/p65 by PKC alpha.	Tetradecanoylphorbol Acetate	9-12	protein kinase C alpha	Homo sapiens	61-70
20152819-8	2010	Furthermore, DHA strongly repressed the PMA-induced phosphorylation of Raf/ERK and JNK, which are dependent on the PKCalpha pathway.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 1	Homo sapiens	75-78
20152819-8	2010	Furthermore, DHA strongly repressed the PMA-induced phosphorylation of Raf/ERK and JNK, which are dependent on the PKCalpha pathway.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 8	Homo sapiens	83-86
20152819-8	2010	Furthermore, DHA strongly repressed the PMA-induced phosphorylation of Raf/ERK and JNK, which are dependent on the PKCalpha pathway.	Tetradecanoylphorbol Acetate	40-43	protein kinase C alpha	Homo sapiens	115-123
20345481-5	2010	When U937 cells were treated with phorbol myristate acetate (PHA) or gamma-interferon, they significantly expressed both HO-1 and Bach1, like primary AML cells.	Tetradecanoylphorbol Acetate	34-59	BTB domain and CNC homolog 1	Homo sapiens	130-135
20469933-3	2010	In search of the factors regulating Tspo expression, we recently showed that high levels of TSPO in steroidogenic cells may be due to high constitutive expression of protein kinase Cepsilon (PKCepsilon), while phorbol 12-myristate 13-acetate (PMA) activation of PKCepsilon drives inducible TSPO expression in nonsteroidogenic cells, likely through activator protein 1 (AP1).	Tetradecanoylphorbol Acetate	210-241	translocator protein	Mus musculus	36-40
20469933-3	2010	In search of the factors regulating Tspo expression, we recently showed that high levels of TSPO in steroidogenic cells may be due to high constitutive expression of protein kinase Cepsilon (PKCepsilon), while phorbol 12-myristate 13-acetate (PMA) activation of PKCepsilon drives inducible TSPO expression in nonsteroidogenic cells, likely through activator protein 1 (AP1).	Tetradecanoylphorbol Acetate	243-246	translocator protein	Mus musculus	36-40
20469933-3	2010	In search of the factors regulating Tspo expression, we recently showed that high levels of TSPO in steroidogenic cells may be due to high constitutive expression of protein kinase Cepsilon (PKCepsilon), while phorbol 12-myristate 13-acetate (PMA) activation of PKCepsilon drives inducible TSPO expression in nonsteroidogenic cells, likely through activator protein 1 (AP1).	Tetradecanoylphorbol Acetate	243-246	translocator protein	Mus musculus	92-96
20176058-8	2010	When THP-1 and U937 cells differentiated into macrophages after incubation with 2-O-tetradecanoylphorbol-13-acetate (TPA), they secreted far greater amounts of salusin-beta-LI into the culture supernatant (3351.9 + or - 899.3 and 1545.8 + or - 183.3 fmol/10(5) cells per 24h).	Tetradecanoylphorbol Acetate	117-120	GLI family zinc finger 2	Homo sapiens	5-10
20176058-8	2010	When THP-1 and U937 cells differentiated into macrophages after incubation with 2-O-tetradecanoylphorbol-13-acetate (TPA), they secreted far greater amounts of salusin-beta-LI into the culture supernatant (3351.9 + or - 899.3 and 1545.8 + or - 183.3 fmol/10(5) cells per 24h).	Tetradecanoylphorbol Acetate	117-120	torsin family 2 member A	Homo sapiens	160-172
20176058-9	2010	TPA treatment accelerated the processing of prosalusin into its cleaved fragments, suggesting that the increased secretion of salusin-beta-LI in THP-1-derived macrophages was caused by the enhanced intracellular processing of prosalusin.	Tetradecanoylphorbol Acetate	0-3	torsin family 2 member A	Homo sapiens	44-54
20176058-9	2010	TPA treatment accelerated the processing of prosalusin into its cleaved fragments, suggesting that the increased secretion of salusin-beta-LI in THP-1-derived macrophages was caused by the enhanced intracellular processing of prosalusin.	Tetradecanoylphorbol Acetate	0-3	torsin family 2 member A	Homo sapiens	126-138
20176058-9	2010	TPA treatment accelerated the processing of prosalusin into its cleaved fragments, suggesting that the increased secretion of salusin-beta-LI in THP-1-derived macrophages was caused by the enhanced intracellular processing of prosalusin.	Tetradecanoylphorbol Acetate	0-3	GLI family zinc finger 2	Homo sapiens	145-150
20176058-9	2010	TPA treatment accelerated the processing of prosalusin into its cleaved fragments, suggesting that the increased secretion of salusin-beta-LI in THP-1-derived macrophages was caused by the enhanced intracellular processing of prosalusin.	Tetradecanoylphorbol Acetate	0-3	torsin family 2 member A	Homo sapiens	226-236
20433148-1	2010	Well-defined star-shaped donor-pi-acceptor meta-conjugated systems with broad absorption features were constructed through facilely synthetic routes, in which triphenylamine (TPA) moiety as an electron donor and 2-dicyanomethylen-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) unit as an electron acceptor were introduced in various ratios.	Tetradecanoylphorbol Acetate	175-178	hepatocyte nuclear factor 4 alpha	Homo sapiens	272-275
20469933-10	2010	MEK1/2, c-Jun, and STAT3 knockdown also reduced basal as well as PMA-induced Tspo mRNA levels in NIH-3T3 cells.	Tetradecanoylphorbol Acetate	65-68	signal transducer and activator of transcription 3	Mus musculus	19-24
20469933-10	2010	MEK1/2, c-Jun, and STAT3 knockdown also reduced basal as well as PMA-induced Tspo mRNA levels in NIH-3T3 cells.	Tetradecanoylphorbol Acetate	65-68	translocator protein	Mus musculus	77-81
20172950-4	2010	Maximal TPA activation of protein kinase C (PKCalpha) as measured by activity assays and activation of target genes and induction of cornified envelopes correlated with TGFbeta1 gene dosage in keratinocytes and addition of exogenous TGFbeta1 restored the cornification defect in TGFbeta1+/- keratinocytes.	Tetradecanoylphorbol Acetate	8-11	protein kinase C, alpha	Mus musculus	44-52
20172950-5	2010	Similarly, inhibition of ALK5-suppressed TPA-mediated PKCalpha activation suggesting that physiological levels of TGFbeta1 are required for maximal activation of PKC-dependent mitogenic responses.	Tetradecanoylphorbol Acetate	41-44	transforming growth factor, beta receptor I	Mus musculus	25-29
20172950-5	2010	Similarly, inhibition of ALK5-suppressed TPA-mediated PKCalpha activation suggesting that physiological levels of TGFbeta1 are required for maximal activation of PKC-dependent mitogenic responses.	Tetradecanoylphorbol Acetate	41-44	protein kinase C, alpha	Mus musculus	54-62
20172950-5	2010	Similarly, inhibition of ALK5-suppressed TPA-mediated PKCalpha activation suggesting that physiological levels of TGFbeta1 are required for maximal activation of PKC-dependent mitogenic responses.	Tetradecanoylphorbol Acetate	41-44	protein kinase C, alpha	Mus musculus	54-57
20308057-2	2010	Recently, we demonstrated a role for RasGRP1 in skin carcinogenesis and suggested its participation in the action of tumor-promoting phorbol esters like 12-O-tetradecanoylphorbol-13-acetate (TPA) on Ras pathways in epidermal cells.	Tetradecanoylphorbol Acetate	153-189	RAS guanyl releasing protein 1	Mus musculus	37-44
20539748-1	2010	Alteplase (tissue plasminogen activator, tPA) is currently the only FDA-approved treatment that can be given to acute ischemic stroke (AIS) patients if patients present within 3 h of an ischemic stroke.	Tetradecanoylphorbol Acetate	41-44	plasminogen activator, tissue type	Homo sapiens	0-9
20308057-0	2010	RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes.	Tetradecanoylphorbol Acetate	62-98	RAS guanyl releasing protein 1	Mus musculus	0-7
20299489-9	2010	Taken together, the results show that PMA activates the MEK-ERK pathway and strongly induces miRNA-34a expression, which in turn inhibits cell proliferation by repressing the expression of MEK1.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase kinase 7	Homo sapiens	56-59
20299489-9	2010	Taken together, the results show that PMA activates the MEK-ERK pathway and strongly induces miRNA-34a expression, which in turn inhibits cell proliferation by repressing the expression of MEK1.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase 1	Homo sapiens	60-63
20308057-2	2010	Recently, we demonstrated a role for RasGRP1 in skin carcinogenesis and suggested its participation in the action of tumor-promoting phorbol esters like 12-O-tetradecanoylphorbol-13-acetate (TPA) on Ras pathways in epidermal cells.	Tetradecanoylphorbol Acetate	191-194	RAS guanyl releasing protein 1	Mus musculus	37-44
20308057-6	2010	Furthermore, small hairpin RNA-induced silencing of RasGRP1 abrogated the effect of TPA on Ras.	Tetradecanoylphorbol Acetate	84-87	RAS guanyl releasing protein 1	Mus musculus	52-59
20308057-7	2010	Analysis of Ras isoforms showed that both H-Ras and N-Ras depended on RasGRP1 for activation by TPA, whereas activation of K-Ras could not be detected.	Tetradecanoylphorbol Acetate	96-99	RAS guanyl releasing protein 1	Mus musculus	70-77
20308057-9	2010	Notably, TPA-induced phosphorylation of JNK2, but not JNK1, was reduced by RasGRP1 depletion.	Tetradecanoylphorbol Acetate	9-12	mitogen-activated protein kinase 9	Mus musculus	40-44
20308057-9	2010	Notably, TPA-induced phosphorylation of JNK2, but not JNK1, was reduced by RasGRP1 depletion.	Tetradecanoylphorbol Acetate	9-12	RAS guanyl releasing protein 1	Mus musculus	75-82
20308057-10	2010	These data identify RasGRP1 as a critical molecule in the activation of Ras by TPA in primary mouse keratinocytes and suggest JNK2 as one of the relevant downstream targets.	Tetradecanoylphorbol Acetate	79-82	RAS guanyl releasing protein 1	Mus musculus	20-27
20331435-4	2010	By using PMA and the phosphatase inhibitors cantharidin and calyculin A, we could selectively activate PKC or p38 MAPK respectively to promote TACE-dependent shedding of L-selectin.	Tetradecanoylphorbol Acetate	9-12	mitogen-activated protein kinase 14	Homo sapiens	110-113
20406988-3	2010	We now show that rat epidermal keratinocytes (REK) that are reduced in Cx43 present features of epithelial-to-mesenchymal transition and are more invasive than their control counterparts, whereas overexpression of Cx43 inhibited the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)- and epidermal growth factor (EGF)-induced invasive properties.	Tetradecanoylphorbol Acetate	233-270	gap junction protein, alpha 1	Rattus norvegicus	214-218
20406988-3	2010	We now show that rat epidermal keratinocytes (REK) that are reduced in Cx43 present features of epithelial-to-mesenchymal transition and are more invasive than their control counterparts, whereas overexpression of Cx43 inhibited the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)- and epidermal growth factor (EGF)-induced invasive properties.	Tetradecanoylphorbol Acetate	272-275	gap junction protein, alpha 1	Rattus norvegicus	214-218
20406988-5	2010	Interestingly, the association of Cx43 with Cav-1 was found to be reduced after TPA and EGF treatment.	Tetradecanoylphorbol Acetate	80-83	caveolin 1	Homo sapiens	44-49
20459780-7	2010	PMA/ionomycin stimulation induced a stronger up-regulation of T cell activation than of B cell activation with dominance toward a Th1 response, including IL2, CD69 and TNFRSF9 (tumor necrosis factor receptor superfamily, member 9) genes.	Tetradecanoylphorbol Acetate	0-3	IL2	Sus scrofa	154-157
20218615-2	2010	Herein, we report the investigation of the inhibitory effects of magnolol on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	77-113	nitric oxide synthase 2, inducible	Mus musculus	142-173
20218615-2	2010	Herein, we report the investigation of the inhibitory effects of magnolol on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	77-113	nitric oxide synthase 2, inducible	Mus musculus	175-179
20032081-10	2010	RSG only reduced VEGF- and PMA-stimulated PKCalpha membrane translocation.	Tetradecanoylphorbol Acetate	27-30	protein kinase C alpha	Homo sapiens	42-50
20218615-2	2010	Herein, we report the investigation of the inhibitory effects of magnolol on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	115-118	nitric oxide synthase 2, inducible	Mus musculus	142-173
20218615-2	2010	Herein, we report the investigation of the inhibitory effects of magnolol on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	115-118	nitric oxide synthase 2, inducible	Mus musculus	175-179
20218615-3	2010	We found that the topical application of magnolol effectively inhibited the transcriptional activation of iNOS and COX-2 mRNA and proteins in mouse skin stimulated by TPA.	Tetradecanoylphorbol Acetate	167-170	nitric oxide synthase 2, inducible	Mus musculus	106-110
20218615-4	2010	Pretreatment with magnolol resulted in the reduction of TPA-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunit and DNA binding by blocking the phosphorylation of IkappaBalpha and p65 and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	56-59	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-128
20218615-4	2010	Pretreatment with magnolol resulted in the reduction of TPA-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunit and DNA binding by blocking the phosphorylation of IkappaBalpha and p65 and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	56-59	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	189-201
20218615-4	2010	Pretreatment with magnolol resulted in the reduction of TPA-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunit and DNA binding by blocking the phosphorylation of IkappaBalpha and p65 and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	56-59	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	240-252
20444294-14	2010	Then we showed that TPA not only up regulated miR-101 expression, but also reduced protein level of EZH2, EED and H3K27me3 in HepG2 cells.	Tetradecanoylphorbol Acetate	20-23	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	100-104
20444294-15	2010	Using lenti-virus-mediated shRNA to knockdown endogenous PKCalpha expression, we observed that TPA induced growth arrest, elevation of miR-101 and reduction of EZH2, EED and H3K27me3 proteins were all PKCalpha dependent.	Tetradecanoylphorbol Acetate	95-98	protein kinase C alpha	Homo sapiens	57-65
20444294-15	2010	Using lenti-virus-mediated shRNA to knockdown endogenous PKCalpha expression, we observed that TPA induced growth arrest, elevation of miR-101 and reduction of EZH2, EED and H3K27me3 proteins were all PKCalpha dependent.	Tetradecanoylphorbol Acetate	95-98	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	160-164
20444294-15	2010	Using lenti-virus-mediated shRNA to knockdown endogenous PKCalpha expression, we observed that TPA induced growth arrest, elevation of miR-101 and reduction of EZH2, EED and H3K27me3 proteins were all PKCalpha dependent.	Tetradecanoylphorbol Acetate	95-98	protein kinase C alpha	Homo sapiens	201-209
20423347-6	2010	It significantly decreased TPA-induced translocation of protein kinase Calpha, the phosphorylation and activation of ERK, the nuclear translocation of NF-kappaB and the TPA-induced NF-kappaB-DNA-binding activity in mouse skin.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Mus musculus	117-120
20423347-6	2010	It significantly decreased TPA-induced translocation of protein kinase Calpha, the phosphorylation and activation of ERK, the nuclear translocation of NF-kappaB and the TPA-induced NF-kappaB-DNA-binding activity in mouse skin.	Tetradecanoylphorbol Acetate	27-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	151-160
20423347-6	2010	It significantly decreased TPA-induced translocation of protein kinase Calpha, the phosphorylation and activation of ERK, the nuclear translocation of NF-kappaB and the TPA-induced NF-kappaB-DNA-binding activity in mouse skin.	Tetradecanoylphorbol Acetate	27-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	181-190
20423347-6	2010	It significantly decreased TPA-induced translocation of protein kinase Calpha, the phosphorylation and activation of ERK, the nuclear translocation of NF-kappaB and the TPA-induced NF-kappaB-DNA-binding activity in mouse skin.	Tetradecanoylphorbol Acetate	169-172	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	181-190
20463301-8	2010	In addition, WECG attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 in human mast cells.	Tetradecanoylphorbol Acetate	33-64	tumor necrosis factor	Homo sapiens	172-199
20426528-10	2010	The activation of PKC alpha with phorbol myristate acetate (PMA), a PKC activator, up-regulated cyclin D1 expression and increased the proliferation of passively sensitized HASMCs.	Tetradecanoylphorbol Acetate	33-58	protein kinase C alpha	Homo sapiens	18-27
20426528-10	2010	The activation of PKC alpha with phorbol myristate acetate (PMA), a PKC activator, up-regulated cyclin D1 expression and increased the proliferation of passively sensitized HASMCs.	Tetradecanoylphorbol Acetate	33-58	protein kinase C alpha	Homo sapiens	18-21
20463301-8	2010	In addition, WECG attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 in human mast cells.	Tetradecanoylphorbol Acetate	33-64	interleukin 6	Homo sapiens	204-217
20426528-10	2010	The activation of PKC alpha with phorbol myristate acetate (PMA), a PKC activator, up-regulated cyclin D1 expression and increased the proliferation of passively sensitized HASMCs.	Tetradecanoylphorbol Acetate	60-63	protein kinase C alpha	Homo sapiens	18-27
20426528-10	2010	The activation of PKC alpha with phorbol myristate acetate (PMA), a PKC activator, up-regulated cyclin D1 expression and increased the proliferation of passively sensitized HASMCs.	Tetradecanoylphorbol Acetate	60-63	protein kinase C alpha	Homo sapiens	18-21
20016498-3	2010	In contrast, TPA induces persistent activation of ERK in the absence of oscillations and does not induce efficient migration.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 1	Homo sapiens	50-53
20423459-5	2010	KAT1 expressed in Xenopus oocytes was inhibited by the protein kinase C activator phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	82-113	kynurenine aminotransferase 1 L homeolog	Xenopus laevis	0-4
20033868-5	2010	Real-time PCR and Western blotting indicated that ILN at 5 microM or above significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in the breast cells.	Tetradecanoylphorbol Acetate	99-130	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
20206692-5	2010	Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response.	Tetradecanoylphorbol Acetate	183-219	nuclear factor kappa B subunit 1	Homo sapiens	15-36
20206692-5	2010	Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response.	Tetradecanoylphorbol Acetate	183-219	nuclear factor kappa B subunit 1	Homo sapiens	38-47
20206692-5	2010	Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response.	Tetradecanoylphorbol Acetate	221-224	nuclear factor kappa B subunit 1	Homo sapiens	15-36
20206692-5	2010	Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response.	Tetradecanoylphorbol Acetate	221-224	nuclear factor kappa B subunit 1	Homo sapiens	38-47
20206692-5	2010	Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response.	Tetradecanoylphorbol Acetate	221-224	nuclear factor kappa B subunit 1	Homo sapiens	162-171
20164300-5	2010	Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB.	Tetradecanoylphorbol Acetate	80-111	interleukin 6	Homo sapiens	207-211
20164300-5	2010	Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB.	Tetradecanoylphorbol Acetate	80-111	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
20164300-5	2010	Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB.	Tetradecanoylphorbol Acetate	80-111	nuclear factor kappa B subunit 1	Homo sapiens	269-278
20033868-5	2010	Real-time PCR and Western blotting indicated that ILN at 5 microM or above significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression in the breast cells.	Tetradecanoylphorbol Acetate	132-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
20349957-5	2010	3-DAC shows higher conjugation and is more planar than 4-DAC, and it exhibits a larger TPA cross section.	Tetradecanoylphorbol Acetate	87-90	F-box and WD repeat domain containing 4	Homo sapiens	2-5
20207737-6	2010	Isoproterenol also blocked ERK downstream of phorbol 12-myristate 13-acetate and the P2X(7) and epidermal growth factor receptors.	Tetradecanoylphorbol Acetate	45-76	Eph receptor B1	Rattus norvegicus	27-30
20188714-6	2010	In support of this, treatment of MMP-3- or MMP-9-specific inhibitor significantly suppressed PMA-induced invasion of glioma cells.	Tetradecanoylphorbol Acetate	93-96	matrix metallopeptidase 3	Homo sapiens	33-38
20188714-8	2010	Furthermore, glycitein suppresses PMA-induced phosphorylation of three types of MAP kinases, which are upstream signaling molecules in MMP gene expressions and NF-kappaB and AP-1 activities in glioma cells.	Tetradecanoylphorbol Acetate	34-37	matrix metallopeptidase 3	Homo sapiens	135-138
20158498-7	2010	Whereas numerous mammalian protease inhibitors have no effect on MLK3 proteolysis, blockade of the proteasome through epoxomicin or MG132 abolishes PMA-induced production of the CTF of MLK3.	Tetradecanoylphorbol Acetate	148-151	nuclear factor I C	Homo sapiens	178-181
20053794-9	2010	In the absence of flow, the PKC activator phorbol 12-myristate 13-acetate (200 nM) enhanced net O(2)(-) production from 5 +/- 2 to 92 +/- 6 AU/s (P &lt; 0.001; n = 6).	Tetradecanoylphorbol Acetate	42-73	protein kinase C, alpha	Mus musculus	28-31
20138977-3	2010	First, we suggest that the expression of MMP-9 by TPA involves phosphorylation of IKK, p38, and PKC in hepG2.	Tetradecanoylphorbol Acetate	50-53	mitogen-activated protein kinase 14	Homo sapiens	87-90
20138977-7	2010	Hesperidin suppressed TPA-stimulated NF-kappaB translocation into the nucleus through IkappaB inhibitory signaling pathways and also inhibited TPA-induced AP-1 activity by the inhibitory phosphorylation of p38 kinase and c-Jun N-terminal kinase (JNK) signaling pathways.	Tetradecanoylphorbol Acetate	22-25	mitogen-activated protein kinase 8	Homo sapiens	221-244
20138977-7	2010	Hesperidin suppressed TPA-stimulated NF-kappaB translocation into the nucleus through IkappaB inhibitory signaling pathways and also inhibited TPA-induced AP-1 activity by the inhibitory phosphorylation of p38 kinase and c-Jun N-terminal kinase (JNK) signaling pathways.	Tetradecanoylphorbol Acetate	22-25	mitogen-activated protein kinase 8	Homo sapiens	246-249
20138977-7	2010	Hesperidin suppressed TPA-stimulated NF-kappaB translocation into the nucleus through IkappaB inhibitory signaling pathways and also inhibited TPA-induced AP-1 activity by the inhibitory phosphorylation of p38 kinase and c-Jun N-terminal kinase (JNK) signaling pathways.	Tetradecanoylphorbol Acetate	143-146	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	155-159
20138977-7	2010	Hesperidin suppressed TPA-stimulated NF-kappaB translocation into the nucleus through IkappaB inhibitory signaling pathways and also inhibited TPA-induced AP-1 activity by the inhibitory phosphorylation of p38 kinase and c-Jun N-terminal kinase (JNK) signaling pathways.	Tetradecanoylphorbol Acetate	143-146	mitogen-activated protein kinase 14	Homo sapiens	206-209
20138977-7	2010	Hesperidin suppressed TPA-stimulated NF-kappaB translocation into the nucleus through IkappaB inhibitory signaling pathways and also inhibited TPA-induced AP-1 activity by the inhibitory phosphorylation of p38 kinase and c-Jun N-terminal kinase (JNK) signaling pathways.	Tetradecanoylphorbol Acetate	143-146	mitogen-activated protein kinase 8	Homo sapiens	221-244
20138977-7	2010	Hesperidin suppressed TPA-stimulated NF-kappaB translocation into the nucleus through IkappaB inhibitory signaling pathways and also inhibited TPA-induced AP-1 activity by the inhibitory phosphorylation of p38 kinase and c-Jun N-terminal kinase (JNK) signaling pathways.	Tetradecanoylphorbol Acetate	143-146	mitogen-activated protein kinase 8	Homo sapiens	246-249
20214878-3	2010	To further investigate the role of miRNAs in cell growth and differentiation, we focused on miR-22, a miRNA induced by TPA in the HL-60 leukemia cell line model of monocytic differentiation.	Tetradecanoylphorbol Acetate	119-122	microRNA 22	Homo sapiens	92-98
20214878-4	2010	TPA-induced miR-22 transcription was found to be downstream of the protein kinase c (PKC)-extracellular regulated kinase (ERK) signaling module, a pathway central to the growth and differentiation of many different cell types.	Tetradecanoylphorbol Acetate	0-3	microRNA 22	Homo sapiens	12-18
20106976-3	2010	The level of nSMase2 phosphorylation can be modulated by treatment with anisomycin or phorbol 12-myristate 13-acetate (PMA/12-O-tetradecanoylphorbol-13-acetate), suggesting that p38 mitogen-activated protein kinase (MAPK) and protein kinases Cs are upstream of nSMase2 phosphorylation.	Tetradecanoylphorbol Acetate	86-117	mitogen-activated protein kinase 14	Homo sapiens	178-214
20106976-3	2010	The level of nSMase2 phosphorylation can be modulated by treatment with anisomycin or phorbol 12-myristate 13-acetate (PMA/12-O-tetradecanoylphorbol-13-acetate), suggesting that p38 mitogen-activated protein kinase (MAPK) and protein kinases Cs are upstream of nSMase2 phosphorylation.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 14	Homo sapiens	178-214
20106976-3	2010	The level of nSMase2 phosphorylation can be modulated by treatment with anisomycin or phorbol 12-myristate 13-acetate (PMA/12-O-tetradecanoylphorbol-13-acetate), suggesting that p38 mitogen-activated protein kinase (MAPK) and protein kinases Cs are upstream of nSMase2 phosphorylation.	Tetradecanoylphorbol Acetate	123-159	mitogen-activated protein kinase 14	Homo sapiens	178-214
19618379-8	2010	RESULTS: In comparison with their counterparts without APOE4, patients with at least one copy of the APOE epsilon-4 allele showed higher spontaneous (p = 0.037) and PMA-induced (p = 0.039) production of IL-1beta after controlling for clinical variables.	Tetradecanoylphorbol Acetate	165-168	apolipoprotein E	Homo sapiens	55-59
20020096-7	2010	RESULTS: The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated glucagon secretion from mouse and human islets about fivefold (p &lt; 0.01).	Tetradecanoylphorbol Acetate	27-58	protein kinase C alpha	Homo sapiens	13-16
20020096-7	2010	RESULTS: The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated glucagon secretion from mouse and human islets about fivefold (p &lt; 0.01).	Tetradecanoylphorbol Acetate	60-63	protein kinase C alpha	Homo sapiens	13-16
20074601-4	2010	In vitro stimulation of lymph node cells with either TG, staphylococcus enterotoxin B, or phorbol 12-myristate 13-acetate/ionomycin revealed an interferon-gamma expression in T-bet(+) B cells only in the patient and not in controls.	Tetradecanoylphorbol Acetate	90-121	interferon gamma	Homo sapiens	144-160
19618379-6	2010	PBMCs were isolated from the donors and used to assess spontaneous and PMA-stimulated secretion of TNF-alpha, IL-6, and IL-1beta.	Tetradecanoylphorbol Acetate	71-74	tumor necrosis factor	Homo sapiens	99-108
19618379-8	2010	RESULTS: In comparison with their counterparts without APOE4, patients with at least one copy of the APOE epsilon-4 allele showed higher spontaneous (p = 0.037) and PMA-induced (p = 0.039) production of IL-1beta after controlling for clinical variables.	Tetradecanoylphorbol Acetate	165-168	apolipoprotein E	Homo sapiens	55-60
19919952-4	2010	The HEK 293 cells overexpressing exogenous PTP-PEST were stimulated by 12-O-tetradecanoylphorbol 13-acetate (TPA) and the phosphorylation of PTP-PEST at Ser39 was evaluated using an anti-phospho-Ser39 PTP-PEST specific antibody (anti-pS39-PEST Ab).	Tetradecanoylphorbol Acetate	71-107	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	43-51
19919952-4	2010	The HEK 293 cells overexpressing exogenous PTP-PEST were stimulated by 12-O-tetradecanoylphorbol 13-acetate (TPA) and the phosphorylation of PTP-PEST at Ser39 was evaluated using an anti-phospho-Ser39 PTP-PEST specific antibody (anti-pS39-PEST Ab).	Tetradecanoylphorbol Acetate	109-112	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	43-51
19919952-7	2010	Furthermore, TPA-induced phosphorylation could take place in PTP-PEST catalytic domain, but the phosphorylation of PTP-PEST catalytic domain could not be abrogated by co-transfection of a plasmid expressing wild-type PP1alpha.	Tetradecanoylphorbol Acetate	13-16	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	61-69
19919952-7	2010	Furthermore, TPA-induced phosphorylation could take place in PTP-PEST catalytic domain, but the phosphorylation of PTP-PEST catalytic domain could not be abrogated by co-transfection of a plasmid expressing wild-type PP1alpha.	Tetradecanoylphorbol Acetate	13-16	protein phosphatase 1 catalytic subunit alpha	Homo sapiens	217-225
20140636-4	2010	METHODS: COS-7 cells expressing hOAT4 were treated with PKC activator phorbol 12-myristate 13-acetate (PMA) or transfected with dominant negative mutants of dynamin-2 or Eps15 or transfected with NHERF-1.	Tetradecanoylphorbol Acetate	70-101	solute carrier family 22 member 11	Homo sapiens	32-37
20140636-4	2010	METHODS: COS-7 cells expressing hOAT4 were treated with PKC activator phorbol 12-myristate 13-acetate (PMA) or transfected with dominant negative mutants of dynamin-2 or Eps15 or transfected with NHERF-1.	Tetradecanoylphorbol Acetate	103-106	solute carrier family 22 member 11	Homo sapiens	32-37
19945525-4	2010	TPA can also activate NFkappaB and so we tested whether this was also deficient in the HaCat cells using TNFalpha which signals directly to NFkappaB.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	22-30
19945525-6	2010	Analysis of ERK phosphorylation showed that while TPA mediated ERK phosphorylation occurred in both cell lines it was more robust and difficult to inhibit in Pam212 cells suggesting that there may be an insufficiency in this step in HaCat cells leading to a reduced response.	Tetradecanoylphorbol Acetate	50-53	mitogen-activated protein kinase 1	Mus musculus	12-15
19945525-6	2010	Analysis of ERK phosphorylation showed that while TPA mediated ERK phosphorylation occurred in both cell lines it was more robust and difficult to inhibit in Pam212 cells suggesting that there may be an insufficiency in this step in HaCat cells leading to a reduced response.	Tetradecanoylphorbol Acetate	50-53	mitogen-activated protein kinase 1	Mus musculus	63-66
20360975-6	2010	Phorbol myristate acetate (PMA) upregulated the expression of resistin mRNA in U937 cells by increasing the recruitment of Sp1, ATF-2 and PPARgamma on the resistin gene promoter.	Tetradecanoylphorbol Acetate	0-25	peroxisome proliferator activated receptor gamma	Homo sapiens	138-147
20004183-0	2010	Purification of a peptide from seahorse, that inhibits TPA-induced MMP, iNOS and COX-2 expression through MAPK and NF-kappaB activation, and induces human osteoblastic and chondrocytic differentiation.	Tetradecanoylphorbol Acetate	55-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
20004183-0	2010	Purification of a peptide from seahorse, that inhibits TPA-induced MMP, iNOS and COX-2 expression through MAPK and NF-kappaB activation, and induces human osteoblastic and chondrocytic differentiation.	Tetradecanoylphorbol Acetate	55-58	nuclear factor kappa B subunit 1	Homo sapiens	115-124
20004183-10	2010	To elucidate the mechanisms by which the peptide acted, we examined its effects on TPA-induced MAPKs/NF-kappaB activation and determined that the peptide treatment significantly reduced p38 kinase/NF-kappaB in MG-63 cells and MAPKs/NF-kappaB in SW-1353 cells.	Tetradecanoylphorbol Acetate	83-86	nuclear factor kappa B subunit 1	Homo sapiens	101-110
20004183-10	2010	To elucidate the mechanisms by which the peptide acted, we examined its effects on TPA-induced MAPKs/NF-kappaB activation and determined that the peptide treatment significantly reduced p38 kinase/NF-kappaB in MG-63 cells and MAPKs/NF-kappaB in SW-1353 cells.	Tetradecanoylphorbol Acetate	83-86	nuclear factor kappa B subunit 1	Homo sapiens	197-206
20004183-10	2010	To elucidate the mechanisms by which the peptide acted, we examined its effects on TPA-induced MAPKs/NF-kappaB activation and determined that the peptide treatment significantly reduced p38 kinase/NF-kappaB in MG-63 cells and MAPKs/NF-kappaB in SW-1353 cells.	Tetradecanoylphorbol Acetate	83-86	nuclear factor kappa B subunit 1	Homo sapiens	197-206
20360975-6	2010	Phorbol myristate acetate (PMA) upregulated the expression of resistin mRNA in U937 cells by increasing the recruitment of Sp1, ATF-2 and PPARgamma on the resistin gene promoter.	Tetradecanoylphorbol Acetate	27-30	peroxisome proliferator activated receptor gamma	Homo sapiens	138-147
20007519-6	2010	Coincubation with glutamate agonists and phorbol 12-myristate 13-acetate, a protein kinase C activator, significantly enhanced mean levels of TNF-alpha and RANTES in SW982 cell supernatants compared with incubation with either agent alone.	Tetradecanoylphorbol Acetate	41-72	tumor necrosis factor	Homo sapiens	142-151
19673702-6	2010	Induction of iNOS expression in RAW264.7 cells with LPS (lipopolysaccharide; 1 microg/ml) causes a significant increase in PMA-induced chemiluminescence, which could be enhanced by the NOS substrate, L-arginine, and could be abolished by the NOS inhibitor, L-NNA (NG-nitro-L-arginine).	Tetradecanoylphorbol Acetate	123-126	nitric oxide synthase 2, inducible	Mus musculus	13-17
19673702-8	2010	Inhibition of PKCzeta by its myristoylated pseudosubstrate significantly decreased the PMA-stimulated phosphorylation of the p47phox in LPS-pretreated cells, suggesting that PKCzeta is involved in the iNOS-dependent assembly and activation of NOX.	Tetradecanoylphorbol Acetate	87-90	nitric oxide synthase 2, inducible	Mus musculus	201-205
19673702-9	2010	Taken together, the present study suggests that the induction of iNOS upregulates the PMA-induced assembly of NOX and leads to the enhanced production of ROS via a PKCzeta-dependent mechanism.	Tetradecanoylphorbol Acetate	86-89	nitric oxide synthase 2, inducible	Mus musculus	65-69
20179211-5	2010	DATS also diminished TPA-induced expression of c-Jun and c-Fos, the principal components of AP-1, and blunted the activation of c-Jun NH(2)-terminal kinase (JNK) and Akt.	Tetradecanoylphorbol Acetate	21-24	thymoma viral proto-oncogene 1	Mus musculus	166-169
19995395-4	2010	When placed in culture, NOTCH2 activity was spontaneously decreased in 25 out of 31 CLL cases (81%) within 24 h. DNA-bound N2(IC) complexes could be maintained by the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) or by gamma-interferon (IFN-gamma), two CLL characteristic inducers of CD23 expression.	Tetradecanoylphorbol Acetate	200-231	notch receptor 2	Homo sapiens	24-30
19995395-4	2010	When placed in culture, NOTCH2 activity was spontaneously decreased in 25 out of 31 CLL cases (81%) within 24 h. DNA-bound N2(IC) complexes could be maintained by the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) or by gamma-interferon (IFN-gamma), two CLL characteristic inducers of CD23 expression.	Tetradecanoylphorbol Acetate	233-236	notch receptor 2	Homo sapiens	24-30
19995395-5	2010	Inhibition of PKC-delta by RNA interference or by rottlerin antagonised PMA-induced NOTCH2 activation and also suppressed NOTCH2 activity in CLL cases with constitutively activated NOTCH2 signalling.	Tetradecanoylphorbol Acetate	72-75	notch receptor 2	Homo sapiens	84-90
20179211-6	2010	Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and c-Fos, and inhibition of COX-2 expression in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	192-195	thymoma viral proto-oncogene 1	Mus musculus	35-38
20075180-9	2010	THP-1 cells differentiated into macrophage-like cells by treatment with PMA-internalized fluorescently labeled CRP.	Tetradecanoylphorbol Acetate	72-75	C-reactive protein	Homo sapiens	111-114
20075180-9	2010	THP-1 cells differentiated into macrophage-like cells by treatment with PMA-internalized fluorescently labeled CRP.	Tetradecanoylphorbol Acetate	72-75	GLI family zinc finger 2	Homo sapiens	0-5
20179211-7	2010	The JNK or Akt kinase assay, taking c-Jun fusion protein as a substrate, revealed that TPA induced JNK- or Akt-mediated c-Jun phosphorylation in mouse skin, which was significantly attenuated by DATS or respective pharmacologic inhibitors.	Tetradecanoylphorbol Acetate	87-90	thymoma viral proto-oncogene 1	Mus musculus	11-14
20179211-7	2010	The JNK or Akt kinase assay, taking c-Jun fusion protein as a substrate, revealed that TPA induced JNK- or Akt-mediated c-Jun phosphorylation in mouse skin, which was significantly attenuated by DATS or respective pharmacologic inhibitors.	Tetradecanoylphorbol Acetate	87-90	thymoma viral proto-oncogene 1	Mus musculus	107-110
20179211-9	2010	Taken together, the inhibitory effects of DATS on TPA-induced AP-1 activation and COX-2 expression through modulation of JNK or Akt signaling may partly account for its antitumor-promoting effect on mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	50-53	thymoma viral proto-oncogene 1	Mus musculus	128-131
20121949-4	2010	Using deletion mapping, the TPA-responsive element on the p15(INK4b) promoter was located between 77 and 228 bp upstream of the transcriptional initiation site, within which the putative binding regions of early growth response gene 1 (EGR-1) and stimulatory protein 1 (SP-1) were found.	Tetradecanoylphorbol Acetate	28-31	cyclin dependent kinase inhibitor 2B	Homo sapiens	58-61
20121949-3	2010	This study investigated the detailed mechanisms by which Snail upregulates gene expression of the CDK inhibitor p15(INK4b) in HepG2 induced by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	162-191	snail family transcriptional repressor 1	Homo sapiens	57-62
20121949-4	2010	Using deletion mapping, the TPA-responsive element on the p15(INK4b) promoter was located between 77 and 228 bp upstream of the transcriptional initiation site, within which the putative binding regions of early growth response gene 1 (EGR-1) and stimulatory protein 1 (SP-1) were found.	Tetradecanoylphorbol Acetate	28-31	cyclin dependent kinase inhibitor 2B	Homo sapiens	62-67
20121949-3	2010	This study investigated the detailed mechanisms by which Snail upregulates gene expression of the CDK inhibitor p15(INK4b) in HepG2 induced by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	162-191	cyclin dependent kinase inhibitor 2B	Homo sapiens	112-115
20121949-4	2010	Using deletion mapping, the TPA-responsive element on the p15(INK4b) promoter was located between 77 and 228 bp upstream of the transcriptional initiation site, within which the putative binding regions of early growth response gene 1 (EGR-1) and stimulatory protein 1 (SP-1) were found.	Tetradecanoylphorbol Acetate	28-31	Sp1 transcription factor	Homo sapiens	247-268
20121949-3	2010	This study investigated the detailed mechanisms by which Snail upregulates gene expression of the CDK inhibitor p15(INK4b) in HepG2 induced by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	162-191	cyclin dependent kinase inhibitor 2B	Homo sapiens	116-121
20121949-3	2010	This study investigated the detailed mechanisms by which Snail upregulates gene expression of the CDK inhibitor p15(INK4b) in HepG2 induced by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	193-196	snail family transcriptional repressor 1	Homo sapiens	57-62
20121949-5	2010	Gene expression of EGR-1, Snail and SP-1 can be induced by TPA within 0.5-6 h. In addition, basal levels of SP-1, but not of the other two transcriptional factors, were observed.	Tetradecanoylphorbol Acetate	59-62	snail family transcriptional repressor 1	Homo sapiens	26-31
20121949-3	2010	This study investigated the detailed mechanisms by which Snail upregulates gene expression of the CDK inhibitor p15(INK4b) in HepG2 induced by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	193-196	cyclin dependent kinase inhibitor 2B	Homo sapiens	112-115
20121949-6	2010	Blockade of TPA-induced gene expression of Snail, EGR-1 or SP-1 suppressed activation of the p15-pro228 reporter plasmid harboring the TPA-responsive element.	Tetradecanoylphorbol Acetate	12-15	snail family transcriptional repressor 1	Homo sapiens	43-48
20121949-3	2010	This study investigated the detailed mechanisms by which Snail upregulates gene expression of the CDK inhibitor p15(INK4b) in HepG2 induced by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	193-196	cyclin dependent kinase inhibitor 2B	Homo sapiens	116-121
20121949-6	2010	Blockade of TPA-induced gene expression of Snail, EGR-1 or SP-1 suppressed activation of the p15-pro228 reporter plasmid harboring the TPA-responsive element.	Tetradecanoylphorbol Acetate	12-15	cyclin dependent kinase inhibitor 2B	Homo sapiens	93-96
20121949-6	2010	Blockade of TPA-induced gene expression of Snail, EGR-1 or SP-1 suppressed activation of the p15-pro228 reporter plasmid harboring the TPA-responsive element.	Tetradecanoylphorbol Acetate	135-138	snail family transcriptional repressor 1	Homo sapiens	43-48
20121949-6	2010	Blockade of TPA-induced gene expression of Snail, EGR-1 or SP-1 suppressed activation of the p15-pro228 reporter plasmid harboring the TPA-responsive element.	Tetradecanoylphorbol Acetate	135-138	cyclin dependent kinase inhibitor 2B	Homo sapiens	93-96
20121949-7	2010	More detailed deletion mapping and site-directed mutagenesis further concluded that the overlapping EGR-1/SP-1-binding site was required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	141-144	cyclin dependent kinase inhibitor 2B	Homo sapiens	153-156
20121949-8	2010	In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1.	Tetradecanoylphorbol Acetate	50-53	snail family transcriptional repressor 1	Homo sapiens	113-118
20121949-8	2010	In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1.	Tetradecanoylphorbol Acetate	50-53	snail family transcriptional repressor 1	Homo sapiens	230-235
20121949-8	2010	In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1.	Tetradecanoylphorbol Acetate	182-185	snail family transcriptional repressor 1	Homo sapiens	113-118
20121949-8	2010	In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1.	Tetradecanoylphorbol Acetate	182-185	snail family transcriptional repressor 1	Homo sapiens	230-235
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	125-128	snail family transcriptional repressor 1	Homo sapiens	104-109
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	125-128	snail family transcriptional repressor 1	Homo sapiens	217-222
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	125-128	snail family transcriptional repressor 1	Homo sapiens	217-222
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	125-128	cyclin dependent kinase inhibitor 2B	Homo sapiens	305-308
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	169-172	snail family transcriptional repressor 1	Homo sapiens	104-109
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	169-172	snail family transcriptional repressor 1	Homo sapiens	217-222
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	169-172	snail family transcriptional repressor 1	Homo sapiens	217-222
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	169-172	cyclin dependent kinase inhibitor 2B	Homo sapiens	305-308
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	169-172	snail family transcriptional repressor 1	Homo sapiens	104-109
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	169-172	snail family transcriptional repressor 1	Homo sapiens	217-222
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	169-172	snail family transcriptional repressor 1	Homo sapiens	217-222
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	169-172	cyclin dependent kinase inhibitor 2B	Homo sapiens	305-308
20121949-10	2010	In conclusion, Snail associates with EGR-1 and SP-1 to mediate TPA-induced transcriptional upregulation of p15(INK4b) in HepG2.	Tetradecanoylphorbol Acetate	63-66	snail family transcriptional repressor 1	Homo sapiens	15-20
20121949-10	2010	In conclusion, Snail associates with EGR-1 and SP-1 to mediate TPA-induced transcriptional upregulation of p15(INK4b) in HepG2.	Tetradecanoylphorbol Acetate	63-66	cyclin dependent kinase inhibitor 2B	Homo sapiens	107-110
20121949-10	2010	In conclusion, Snail associates with EGR-1 and SP-1 to mediate TPA-induced transcriptional upregulation of p15(INK4b) in HepG2.	Tetradecanoylphorbol Acetate	63-66	cyclin dependent kinase inhibitor 2B	Homo sapiens	111-116
20179161-7	2010	Furthermore, PD98059, a specific inhibitor of MEK1/2, and Juglone, a potent Pin1 inhibitor, markedly suppressed the expression of activator protein-2alpha and the HER-2 promoter activity induced by EGF or 12-O-tetradecanoylphorbol-13-acetate in MCF-7 cells.	Tetradecanoylphorbol Acetate	205-241	erb-b2 receptor tyrosine kinase 2	Homo sapiens	163-168
20139271-5	2010	Stimulation with PMA/ionomycin caused splenic CD4(+)PD-1(+) T cells to secrete high levels of IFN-gamma, IL-10, low levels of TNF-alpha, faint levels of IL-2, IL-21, and no IL-4, IL-17.	Tetradecanoylphorbol Acetate	17-20	IL10	Sus scrofa	105-110
20139271-5	2010	Stimulation with PMA/ionomycin caused splenic CD4(+)PD-1(+) T cells to secrete high levels of IFN-gamma, IL-10, low levels of TNF-alpha, faint levels of IL-2, IL-21, and no IL-4, IL-17.	Tetradecanoylphorbol Acetate	17-20	IL2	Sus scrofa	153-157
20053683-2	2010	Here, we demonstrate that during the phorbol 12-myristate 13-acetate (PMA)-induced differentiation of HL-60 cells toward macrophages, beta-actin translocates from the cytoplasm to the nucleus and that this process is dramatically inhibited by pretreatment with p38 mitogen-activated protein kinase inhibitors.	Tetradecanoylphorbol Acetate	37-68	mitogen-activated protein kinase 14	Homo sapiens	261-264
20053683-2	2010	Here, we demonstrate that during the phorbol 12-myristate 13-acetate (PMA)-induced differentiation of HL-60 cells toward macrophages, beta-actin translocates from the cytoplasm to the nucleus and that this process is dramatically inhibited by pretreatment with p38 mitogen-activated protein kinase inhibitors.	Tetradecanoylphorbol Acetate	70-73	mitogen-activated protein kinase 14	Homo sapiens	261-264
20032465-8	2010	The PKC activator phorbol 12-myristate 13-acetate partially rescued FTY720-induced down-regulation of the S1P(1) receptor, linking PKC activation with S1P(1) receptor surface expression.	Tetradecanoylphorbol Acetate	18-49	sphingosine-1-phosphate receptor 1	Rattus norvegicus	106-112
20032465-8	2010	The PKC activator phorbol 12-myristate 13-acetate partially rescued FTY720-induced down-regulation of the S1P(1) receptor, linking PKC activation with S1P(1) receptor surface expression.	Tetradecanoylphorbol Acetate	18-49	sphingosine-1-phosphate receptor 1	Rattus norvegicus	151-157
19969058-12	2010	CONCLUSION: Bee venom inhibits PMA-induced MMP-9 expression and activity by inhibition of NF-kappaB via p38 MAPK and JNK signaling pathways in MCF-7 cells.	Tetradecanoylphorbol Acetate	31-34	nuclear factor kappa B subunit 1	Homo sapiens	90-99
20082219-5	2010	In addition, melittin suppressed the PMA-induced phosphorylations of ERK and JNK mitogen-activated protein kinases, upstream factors involved in Ap-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 8	Homo sapiens	77-80
20082219-5	2010	In addition, melittin suppressed the PMA-induced phosphorylations of ERK and JNK mitogen-activated protein kinases, upstream factors involved in Ap-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	37-40	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	145-149
20082219-5	2010	In addition, melittin suppressed the PMA-induced phosphorylations of ERK and JNK mitogen-activated protein kinases, upstream factors involved in Ap-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	37-40	nuclear factor kappa B subunit 1	Homo sapiens	154-163
20053986-2	2010	To bind to its target AP-1/12-O-tetradecanoylphorbol-13-acetate-responsive element or cAMP-responsive element DNA sequences in gene promoters and exert its transcriptional part, c-Fos must heterodimerize with other bZip proteins, its best studied partners being the Jun proteins (c-Jun, JunB, and JunD).	Tetradecanoylphorbol Acetate	27-63	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	287-291
19969058-12	2010	CONCLUSION: Bee venom inhibits PMA-induced MMP-9 expression and activity by inhibition of NF-kappaB via p38 MAPK and JNK signaling pathways in MCF-7 cells.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 1	Homo sapiens	104-107
19969058-12	2010	CONCLUSION: Bee venom inhibits PMA-induced MMP-9 expression and activity by inhibition of NF-kappaB via p38 MAPK and JNK signaling pathways in MCF-7 cells.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 3	Homo sapiens	108-112
19969058-12	2010	CONCLUSION: Bee venom inhibits PMA-induced MMP-9 expression and activity by inhibition of NF-kappaB via p38 MAPK and JNK signaling pathways in MCF-7 cells.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 8	Homo sapiens	117-120
19956200-2	2010	Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation to an adherent monocytic phenotype.	Tetradecanoylphorbol Acetate	6-31	GLI family zinc finger 2	Homo sapiens	80-85
19931518-4	2010	Phorbol 12-myristate 13-acetate (PMA) induces COX-2 expression and production of prostaglandin E(2) (PGE(2)).	Tetradecanoylphorbol Acetate	0-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
19931518-4	2010	Phorbol 12-myristate 13-acetate (PMA) induces COX-2 expression and production of prostaglandin E(2) (PGE(2)).	Tetradecanoylphorbol Acetate	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
20043135-0	2010	Cordycepin inhibits TPA-induced matrix metalloproteinase-9 expression by suppressing the MAPK/AP-1 pathway in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	20-23	mitogen-activated protein kinase 1	Homo sapiens	89-93
20025870-7	2010	In contrast, treatment of HASM by PMA induces phosphorylation and activation of Ra, MEK1/2, ERK1/2, JNK, Elk-1, and c-Jun.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 3	Homo sapiens	92-98
20025870-7	2010	In contrast, treatment of HASM by PMA induces phosphorylation and activation of Ra, MEK1/2, ERK1/2, JNK, Elk-1, and c-Jun.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 8	Homo sapiens	100-103
20169155-8	2010	In MCF-7 breast carcinoma cells, phorbol 12-myristate 13-acetate (PMA) treatment induced L-plastin translocation to de novo actin polymerization sites in ruffling membranes and spike-like structures and highly increased its Ser5 phosphorylation.	Tetradecanoylphorbol Acetate	33-64	lymphocyte cytosolic protein 1	Homo sapiens	89-98
20169155-8	2010	In MCF-7 breast carcinoma cells, phorbol 12-myristate 13-acetate (PMA) treatment induced L-plastin translocation to de novo actin polymerization sites in ruffling membranes and spike-like structures and highly increased its Ser5 phosphorylation.	Tetradecanoylphorbol Acetate	66-69	lymphocyte cytosolic protein 1	Homo sapiens	89-98
20169155-9	2010	Both inhibition studies and siRNA knock-down of PKC isozymes pointed to the involvement of the novel PKC-delta isozyme in the PMA-elicited signaling pathway leading to L-plastin Ser5 phosphorylation.	Tetradecanoylphorbol Acetate	126-129	lymphocyte cytosolic protein 1	Homo sapiens	168-177
19336421-8	2010	A significant difference was found between risk allele carriers and non-carriers of rs10818488 for the expression level of TRAF1 in phorbol myristate acetate-stimulated lymphoblastoid cell lines (p = 0.04).	Tetradecanoylphorbol Acetate	132-157	TNF receptor associated factor 1	Homo sapiens	123-128
19956200-2	2010	Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation to an adherent monocytic phenotype.	Tetradecanoylphorbol Acetate	6-31	MLLT3 super elongation complex subunit	Homo sapiens	122-127
19956200-2	2010	Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation to an adherent monocytic phenotype.	Tetradecanoylphorbol Acetate	33-36	GLI family zinc finger 2	Homo sapiens	80-85
19956200-2	2010	Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation to an adherent monocytic phenotype.	Tetradecanoylphorbol Acetate	33-36	MLLT3 super elongation complex subunit	Homo sapiens	122-127
19768635-0	2010	Plumbagin inhibits TPA-induced MMP-2 and u-PA expressions by reducing binding activities of NF-kappaB and AP-1 via ERK signaling pathway in A549 human lung cancer cells.	Tetradecanoylphorbol Acetate	19-22	plasminogen activator, urokinase	Homo sapiens	41-45
20026373-10	2010	Protocatechuic acid also diminished the level and activity of TPA-induced iNOS, which might be related to its weak effect on IkappaBalpha degradation.	Tetradecanoylphorbol Acetate	62-65	nitric oxide synthase 2, inducible	Mus musculus	74-78
19768635-0	2010	Plumbagin inhibits TPA-induced MMP-2 and u-PA expressions by reducing binding activities of NF-kappaB and AP-1 via ERK signaling pathway in A549 human lung cancer cells.	Tetradecanoylphorbol Acetate	19-22	nuclear factor kappa B subunit 1	Homo sapiens	92-101
19768635-0	2010	Plumbagin inhibits TPA-induced MMP-2 and u-PA expressions by reducing binding activities of NF-kappaB and AP-1 via ERK signaling pathway in A549 human lung cancer cells.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase 3	Homo sapiens	115-118
19768635-3	2010	Data also showed plumbagin could inhibit the activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) involved in the down-regulating enzyme activities, protein and messenger RNA levels of matrix metalloproteinase-2 (MMP-2), and urokinase-type plasminogen activator (u-PA) induced by TPA.	Tetradecanoylphorbol Acetate	296-299	mitogen-activated protein kinase 1	Homo sapiens	59-104
19768635-3	2010	Data also showed plumbagin could inhibit the activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) involved in the down-regulating enzyme activities, protein and messenger RNA levels of matrix metalloproteinase-2 (MMP-2), and urokinase-type plasminogen activator (u-PA) induced by TPA.	Tetradecanoylphorbol Acetate	296-299	mitogen-activated protein kinase 3	Homo sapiens	106-112
19768635-4	2010	Next, plumbagin also strongly inhibited TPA-induced phosphorylation and degradation of inhibitor of kappaBalpha (IkappaBalpha), and the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun.	Tetradecanoylphorbol Acetate	40-43	NFKB inhibitor alpha	Homo sapiens	113-125
19768635-4	2010	Next, plumbagin also strongly inhibited TPA-induced phosphorylation and degradation of inhibitor of kappaBalpha (IkappaBalpha), and the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun.	Tetradecanoylphorbol Acetate	40-43	nuclear factor kappa B subunit 1	Homo sapiens	178-187
19768635-6	2010	Further, the treatment of specific inhibitor for ERK (U0126) to A549 cells could inhibit TPA-induced MMP-2 and u-PA expressions along with an inhibition on cell invasion and migration.	Tetradecanoylphorbol Acetate	89-92	plasminogen activator, urokinase	Homo sapiens	111-115
19784811-9	2010	In the presence of the RXR agonists 9-cis retinoic acid or SR11237, PMA-induced THP-1 cells became less adherent, showed decreased macrophage-like morphological changes, decreased cell surface antigen CD11b and CD36 expression, and down regulated the phagocytosis of latex beads and the production of TNF-alpha and MMP-9.	Tetradecanoylphorbol Acetate	68-71	tumor necrosis factor	Homo sapiens	301-310
20026373-0	2010	Naturally occurring phenolic acids inhibit 12-O-tetradecanoylphorbol-13-acetate induced NF-kappaB, iNOS and COX-2 activation in mouse epidermis.	Tetradecanoylphorbol Acetate	43-79	nitric oxide synthase 2, inducible	Mus musculus	99-103
20043876-6	2010	Using mass spectrometry, we report now that TRPV4 is phosphorylated on serine 824 by the PKC-activating phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	104-135	proline rich transmembrane protein 2	Homo sapiens	89-92
20026373-10	2010	Protocatechuic acid also diminished the level and activity of TPA-induced iNOS, which might be related to its weak effect on IkappaBalpha degradation.	Tetradecanoylphorbol Acetate	62-65	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	125-137
19887445-1	2010	Although treatment with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) is known to protect a subset of cells from induction of apoptosis by death ligands such as Fas ligand and tumor necrosis factor-alpha-related apoptosis-inducing ligand, the mechanism of this protection is unknown.	Tetradecanoylphorbol Acetate	61-92	protein kinase C alpha	Homo sapiens	46-49
19887445-1	2010	Although treatment with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) is known to protect a subset of cells from induction of apoptosis by death ligands such as Fas ligand and tumor necrosis factor-alpha-related apoptosis-inducing ligand, the mechanism of this protection is unknown.	Tetradecanoylphorbol Acetate	61-92	tumor necrosis factor	Homo sapiens	205-232
19887445-1	2010	Although treatment with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) is known to protect a subset of cells from induction of apoptosis by death ligands such as Fas ligand and tumor necrosis factor-alpha-related apoptosis-inducing ligand, the mechanism of this protection is unknown.	Tetradecanoylphorbol Acetate	94-97	protein kinase C alpha	Homo sapiens	46-49
19887445-1	2010	Although treatment with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) is known to protect a subset of cells from induction of apoptosis by death ligands such as Fas ligand and tumor necrosis factor-alpha-related apoptosis-inducing ligand, the mechanism of this protection is unknown.	Tetradecanoylphorbol Acetate	94-97	tumor necrosis factor	Homo sapiens	205-232
20606309-3	2010	In this study, the effect of curcumin and curcumin analogues on COX-2 expression induced by phorbol 12-myristate 13-acetate (PMA) were investigated.	Tetradecanoylphorbol Acetate	92-123	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-69
19954165-11	2010	Under similar conditions, the 3-Hfl complexes of Co(II), Ni(II), and Cu(II) undergo flavonolate ligand exchange to produce [(6-Ph(2)TPA)M(CD(3)CN)(n)](X)(2) (M = Co, Ni, Cu; n = 1 or 2) and [Zn(3-Hfl)(2).2H(2)O].	Tetradecanoylphorbol Acetate	132-135	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
20606309-3	2010	In this study, the effect of curcumin and curcumin analogues on COX-2 expression induced by phorbol 12-myristate 13-acetate (PMA) were investigated.	Tetradecanoylphorbol Acetate	125-128	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-69
20606309-4	2010	We found that a novel curcumin analogue (GL63) inhibited PMA-induced COX-2 mRNA and protein levels in H460 cells to a greater degree than curcumin.	Tetradecanoylphorbol Acetate	57-60	prostaglandin-endoperoxide synthase 2	Homo sapiens	69-74
20606309-7	2010	Taken together, our results provide evidence that the novel curcumin analogue can effectively inhibit PMA-induced COX-2 expression in H460 cells, a mechanism associated with COX-2 mRNA stability and post-transcriptional regulation.	Tetradecanoylphorbol Acetate	102-105	prostaglandin-endoperoxide synthase 2	Homo sapiens	114-119
20606309-7	2010	Taken together, our results provide evidence that the novel curcumin analogue can effectively inhibit PMA-induced COX-2 expression in H460 cells, a mechanism associated with COX-2 mRNA stability and post-transcriptional regulation.	Tetradecanoylphorbol Acetate	102-105	prostaglandin-endoperoxide synthase 2	Homo sapiens	174-179
20119960-5	2010	To demonstrate its utility, this method has been applied to the quantitation of the mRNA levels for two transcription factors, Klf4 and Sox5, and a housekeeping gene, Gapdh, in human leukemia K562 cells before and after induction with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	235-266	SRY-box transcription factor 5	Homo sapiens	136-140
20823576-6	2010	Uptake of L-lactic acid appeared to be stimulated by phorbol 12-myristate 13-acetate (PMA, a PKC activator) via an increase in Vmax of transport processes with no alteration in Km.	Tetradecanoylphorbol Acetate	53-84	proline rich transmembrane protein 2	Homo sapiens	93-96
20823576-6	2010	Uptake of L-lactic acid appeared to be stimulated by phorbol 12-myristate 13-acetate (PMA, a PKC activator) via an increase in Vmax of transport processes with no alteration in Km.	Tetradecanoylphorbol Acetate	86-89	proline rich transmembrane protein 2	Homo sapiens	93-96
20823576-7	2010	In parallel, PMA treatment also resulted in an increase in the level of MCT1 expression.	Tetradecanoylphorbol Acetate	13-16	solute carrier family 16 member 1	Homo sapiens	72-76
20798497-1	2010	BACKGROUND: In this report, we explored the role of PKCalpha and PKCe as mediators of phorbol 12-myristate13-acetate (PMA)-induced proliferation in pituitary tumor GH3B6 cells, and determined if the ERK1/2 and Akt pathways were activated.	Tetradecanoylphorbol Acetate	86-116	protein kinase C, epsilon	Rattus norvegicus	65-69
20798497-1	2010	BACKGROUND: In this report, we explored the role of PKCalpha and PKCe as mediators of phorbol 12-myristate13-acetate (PMA)-induced proliferation in pituitary tumor GH3B6 cells, and determined if the ERK1/2 and Akt pathways were activated.	Tetradecanoylphorbol Acetate	118-121	protein kinase C, epsilon	Rattus norvegicus	65-69
20798497-1	2010	BACKGROUND: In this report, we explored the role of PKCalpha and PKCe as mediators of phorbol 12-myristate13-acetate (PMA)-induced proliferation in pituitary tumor GH3B6 cells, and determined if the ERK1/2 and Akt pathways were activated.	Tetradecanoylphorbol Acetate	118-121	AKT serine/threonine kinase 1	Rattus norvegicus	210-213
20798497-5	2010	RESULTS: Incubation with PMA for 15 min stimulated PKCalpha and PKCe activation, which was correlated with the phosphorylation of ERK1/2 but not Akt.	Tetradecanoylphorbol Acetate	25-28	protein kinase C, epsilon	Rattus norvegicus	64-68
20798497-5	2010	RESULTS: Incubation with PMA for 15 min stimulated PKCalpha and PKCe activation, which was correlated with the phosphorylation of ERK1/2 but not Akt.	Tetradecanoylphorbol Acetate	25-28	AKT serine/threonine kinase 1	Rattus norvegicus	145-148
20185911-8	2010	RESULTS: DFO significantly reduced the intracellular iron level, and led to approximately 70% reduction of MDR1 mRNA, approximately 50% of reduction of H-Fn mRNA and approximately 30% reduction of P-gp protein in TPA-differentiated K562 cells.	Tetradecanoylphorbol Acetate	213-216	ATP binding cassette subfamily B member 1	Homo sapiens	197-201
20350353-7	2010	Based on the results obtained, it can be concluded that TPA and high concentrations of other growth factors intensify the proliferation of melanocytes, without the risk of damage to the HRAS (exon 1 and 2), KRAS (exon 1 and 2), NRAS (exon 1 and 2), and BRAF (exon 11 and 15) genes.	Tetradecanoylphorbol Acetate	56-59	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	253-257
20119960-5	2010	To demonstrate its utility, this method has been applied to the quantitation of the mRNA levels for two transcription factors, Klf4 and Sox5, and a housekeeping gene, Gapdh, in human leukemia K562 cells before and after induction with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	235-266	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	167-172
20119960-6	2010	Interestingly, we found a significant downregulation of the mRNA level of Sox5 after phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	85-116	SRY-box transcription factor 5	Homo sapiens	74-78
19766691-0	2010	Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity.	Tetradecanoylphorbol Acetate	18-43	mitogen-activated protein kinase 1	Homo sapiens	89-92
21087472-8	2010	ERK1/2 phosphorylation induced by co-stimulation with phorbol 12-myristate 13-acetate and calcium ionophore A23187 was depressed in patients.	Tetradecanoylphorbol Acetate	54-85	mitogen-activated protein kinase 3	Homo sapiens	0-6
19766691-0	2010	Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase 1	Homo sapiens	89-92
19766691-5	2010	Curcumin inhibited PMA-mediated activation of extracellular signal-regulated kinase (ERK) and NF-kappaB transcriptional activity.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase 1	Homo sapiens	46-83
19766691-5	2010	Curcumin inhibited PMA-mediated activation of extracellular signal-regulated kinase (ERK) and NF-kappaB transcriptional activity.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase 1	Homo sapiens	85-88
19789931-7	2010	Moreover, AAS significantly inhibited production of inflammatory cytokines, tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells.	Tetradecanoylphorbol Acetate	141-172	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	10-13
19789931-7	2010	Moreover, AAS significantly inhibited production of inflammatory cytokines, tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells.	Tetradecanoylphorbol Acetate	141-172	tumor necrosis factor	Homo sapiens	76-97
19789931-7	2010	Moreover, AAS significantly inhibited production of inflammatory cytokines, tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells.	Tetradecanoylphorbol Acetate	141-172	tumor necrosis factor	Homo sapiens	99-102
19789931-7	2010	Moreover, AAS significantly inhibited production of inflammatory cytokines, tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells.	Tetradecanoylphorbol Acetate	141-172	interleukin 6	Homo sapiens	105-123
19789931-7	2010	Moreover, AAS significantly inhibited production of inflammatory cytokines, tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells.	Tetradecanoylphorbol Acetate	141-172	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
20110595-5	2010	Basal and PMA-stimulated levels of IFN-gamma, TNF-alpha, and IL-6 were measured by ELISPOT (PBMC culture supernatant).	Tetradecanoylphorbol Acetate	10-13	interferon gamma	Homo sapiens	35-44
19737897-4	2010	In this study, we characterized the innate immune response elicited by PGA in the human monocytic cell line THP-1, which was differentiated into macrophages with phorbol 12-myristate 13-acetate (PMA) and human monocyte-derived dendritic cells (hMoDCs).	Tetradecanoylphorbol Acetate	162-193	GLI family zinc finger 2	Homo sapiens	108-113
20523061-8	2010	In contrast, salbutamol significantly inhibited the spontaneous and ionomycin- plus PMA-stimulated production of IFN-gamma by PBMCs from asthmatics.	Tetradecanoylphorbol Acetate	84-87	interferon gamma	Homo sapiens	113-122
20157239-8	2010	On the other hand, phorbol-12-myristate-13-acetate, an activator of PKC, induced the expression of c-gelsolin.	Tetradecanoylphorbol Acetate	19-50	proline rich transmembrane protein 2	Homo sapiens	68-71
20110595-5	2010	Basal and PMA-stimulated levels of IFN-gamma, TNF-alpha, and IL-6 were measured by ELISPOT (PBMC culture supernatant).	Tetradecanoylphorbol Acetate	10-13	tumor necrosis factor	Homo sapiens	46-55
20110595-5	2010	Basal and PMA-stimulated levels of IFN-gamma, TNF-alpha, and IL-6 were measured by ELISPOT (PBMC culture supernatant).	Tetradecanoylphorbol Acetate	10-13	interleukin 6	Homo sapiens	61-65
20492173-0	2010	alpha-Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells.	Tetradecanoylphorbol Acetate	54-57	mitogen-activated protein kinase 3	Homo sapiens	107-110
20936133-4	2010	This correlation was abolished when the cells were stimulated with TPA and ionomycin, which bypass TCR and introduce signals directly into the cells, but the production of IFN-gamma by SLE T cells remained abnormally elevated.	Tetradecanoylphorbol Acetate	67-70	interferon gamma	Homo sapiens	172-181
20734918-11	2010	DLBS1425 also down-regulated c-fos and HER-2/neu mRNA expression in TPA- or fatty acid-induced MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	68-71	erb-b2 receptor tyrosine kinase 2	Homo sapiens	39-48
20492173-3	2010	Data also showed alpha-mangostin could inhibit the activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) involved in the downregulation the enzyme activities, protein, and messenger RNA levels of MMP-2 and MMP-9 induced by TPA.	Tetradecanoylphorbol Acetate	238-241	mitogen-activated protein kinase 1	Homo sapiens	65-110
19804834-4	2010	Stimulation of intracellular peroxide production by TPA was detected by a DCHF-DA assay, and the addition of superoxide dismutase (SOD) or tempol significantly inhibited TPA-induced migration/invasion and COX-2 protein expression accompanied by a decrease in peroxide production.	Tetradecanoylphorbol Acetate	170-173	superoxide dismutase 1	Homo sapiens	109-129
20492173-3	2010	Data also showed alpha-mangostin could inhibit the activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) involved in the downregulation the enzyme activities, protein, and messenger RNA levels of MMP-2 and MMP-9 induced by TPA.	Tetradecanoylphorbol Acetate	238-241	mitogen-activated protein kinase 3	Homo sapiens	112-118
20492173-4	2010	Next, alpha-mangostin also strongly inhibited TPA-induced degradation of inhibitor of kappaBalpha (IkappaBalpha) and the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun.	Tetradecanoylphorbol Acetate	46-49	NFKB inhibitor alpha	Homo sapiens	99-111
20492173-4	2010	Next, alpha-mangostin also strongly inhibited TPA-induced degradation of inhibitor of kappaBalpha (IkappaBalpha) and the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun.	Tetradecanoylphorbol Acetate	46-49	nuclear factor kappa B subunit 1	Homo sapiens	163-172
20492173-6	2010	Further, the treatment of specific inhibitor for ERK (U0126) to MCF-7 cells could inhibit TPA-induced MMP-2 and MMP-9 expressions along with an inhibition on cell invasion and migration.	Tetradecanoylphorbol Acetate	90-93	mitogen-activated protein kinase 3	Homo sapiens	49-52
20492175-0	2010	Acacetin inhibits TPA-induced MMP-2 and u-PA expressions of human lung cancer cells through inactivating JNK signaling pathway and reducing binding activities of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	18-21	plasminogen activator, urokinase	Homo sapiens	40-44
20492175-0	2010	Acacetin inhibits TPA-induced MMP-2 and u-PA expressions of human lung cancer cells through inactivating JNK signaling pathway and reducing binding activities of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	18-21	mitogen-activated protein kinase 8	Homo sapiens	105-108
20492175-0	2010	Acacetin inhibits TPA-induced MMP-2 and u-PA expressions of human lung cancer cells through inactivating JNK signaling pathway and reducing binding activities of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	18-21	nuclear factor kappa B subunit 1	Homo sapiens	162-171
20492175-2	2010	The effect of acacetin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMPs and u-PA expressions in human lung cancer A549 cells was investigated.	Tetradecanoylphorbol Acetate	26-62	plasminogen activator, urokinase	Homo sapiens	86-90
20492175-2	2010	The effect of acacetin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMPs and u-PA expressions in human lung cancer A549 cells was investigated.	Tetradecanoylphorbol Acetate	64-67	plasminogen activator, urokinase	Homo sapiens	86-90
20492175-4	2010	Data also showed acacetin could inhibit phosphorylation of c-Jun N-terminal kinase 1 and 2 (JNK1/2) involved in the down-regulating protein expressions and transcriptions of matrix metalloproteinase-2 (MMP-2) and urokinase-type plasminogen activator (u-PA) induced by TPA.	Tetradecanoylphorbol Acetate	268-271	mitogen-activated protein kinase 8	Homo sapiens	59-90
20492175-4	2010	Data also showed acacetin could inhibit phosphorylation of c-Jun N-terminal kinase 1 and 2 (JNK1/2) involved in the down-regulating protein expressions and transcriptions of matrix metalloproteinase-2 (MMP-2) and urokinase-type plasminogen activator (u-PA) induced by TPA.	Tetradecanoylphorbol Acetate	268-271	mitogen-activated protein kinase 8	Homo sapiens	92-98
19804834-2	2010	A dose- and time-dependent increase in cyclooxygenase-2 (COX-2) gene expression with elevated prostaglandin E(2) (PGE(2)) production was identified in TPA- but not in 4alpha-TPA (a respective inactive compound)-treated U87 cells TPA-induced migration/invasion was significantly blocked by adding the COX-2-specific inhibitor, NS398, through a reduction in PGE(2) production.	Tetradecanoylphorbol Acetate	151-154	prostaglandin-endoperoxide synthase 2	Homo sapiens	39-55
19804834-2	2010	A dose- and time-dependent increase in cyclooxygenase-2 (COX-2) gene expression with elevated prostaglandin E(2) (PGE(2)) production was identified in TPA- but not in 4alpha-TPA (a respective inactive compound)-treated U87 cells TPA-induced migration/invasion was significantly blocked by adding the COX-2-specific inhibitor, NS398, through a reduction in PGE(2) production.	Tetradecanoylphorbol Acetate	151-154	prostaglandin-endoperoxide synthase 2	Homo sapiens	57-62
19804834-2	2010	A dose- and time-dependent increase in cyclooxygenase-2 (COX-2) gene expression with elevated prostaglandin E(2) (PGE(2)) production was identified in TPA- but not in 4alpha-TPA (a respective inactive compound)-treated U87 cells TPA-induced migration/invasion was significantly blocked by adding the COX-2-specific inhibitor, NS398, through a reduction in PGE(2) production.	Tetradecanoylphorbol Acetate	151-154	prostaglandin-endoperoxide synthase 2	Homo sapiens	300-305
19804834-2	2010	A dose- and time-dependent increase in cyclooxygenase-2 (COX-2) gene expression with elevated prostaglandin E(2) (PGE(2)) production was identified in TPA- but not in 4alpha-TPA (a respective inactive compound)-treated U87 cells TPA-induced migration/invasion was significantly blocked by adding the COX-2-specific inhibitor, NS398, through a reduction in PGE(2) production.	Tetradecanoylphorbol Acetate	174-177	prostaglandin-endoperoxide synthase 2	Homo sapiens	39-55
19804834-2	2010	A dose- and time-dependent increase in cyclooxygenase-2 (COX-2) gene expression with elevated prostaglandin E(2) (PGE(2)) production was identified in TPA- but not in 4alpha-TPA (a respective inactive compound)-treated U87 cells TPA-induced migration/invasion was significantly blocked by adding the COX-2-specific inhibitor, NS398, through a reduction in PGE(2) production.	Tetradecanoylphorbol Acetate	174-177	prostaglandin-endoperoxide synthase 2	Homo sapiens	57-62
19804834-3	2010	Data from the pharmacological studies using specific chemical inhibitors showed that activation of protein kinase C (PKC) and extracellular signal-regulated kinases (ERKs) was involved in TPA-induced migration/invasion, COX-2 protein expression, and MMP-9 activation.	Tetradecanoylphorbol Acetate	188-191	mitogen-activated protein kinase 1	Homo sapiens	166-170
19804834-3	2010	Data from the pharmacological studies using specific chemical inhibitors showed that activation of protein kinase C (PKC) and extracellular signal-regulated kinases (ERKs) was involved in TPA-induced migration/invasion, COX-2 protein expression, and MMP-9 activation.	Tetradecanoylphorbol Acetate	188-191	prostaglandin-endoperoxide synthase 2	Homo sapiens	220-225
20492175-5	2010	Next, acacetin also strongly inhibited TPA-stimulated the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun.	Tetradecanoylphorbol Acetate	39-42	nuclear factor kappa B subunit 1	Homo sapiens	76-98
20492175-5	2010	Next, acacetin also strongly inhibited TPA-stimulated the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun.	Tetradecanoylphorbol Acetate	39-42	nuclear factor kappa B subunit 1	Homo sapiens	100-109
20492175-7	2010	Further, the treatment of specific inhibitor for JNK (SP600125) to A549 cells could inhibit TPA-induced MMP-2 and u-PA expressions along with an inhibition on cell invasion and migration.	Tetradecanoylphorbol Acetate	92-95	mitogen-activated protein kinase 8	Homo sapiens	49-52
20492175-7	2010	Further, the treatment of specific inhibitor for JNK (SP600125) to A549 cells could inhibit TPA-induced MMP-2 and u-PA expressions along with an inhibition on cell invasion and migration.	Tetradecanoylphorbol Acetate	92-95	plasminogen activator, urokinase	Homo sapiens	114-118
20492175-8	2010	Taken together, these results suggest the antimetastatic effects of acacetin on the TPA-induced A549 cells might be by reducing MMP-2 and u-PA expressions through inhibiting phosphorylation of JNK and reducing NF-kappaB and AP-1 binding activities.	Tetradecanoylphorbol Acetate	84-87	plasminogen activator, urokinase	Homo sapiens	138-142
20492175-8	2010	Taken together, these results suggest the antimetastatic effects of acacetin on the TPA-induced A549 cells might be by reducing MMP-2 and u-PA expressions through inhibiting phosphorylation of JNK and reducing NF-kappaB and AP-1 binding activities.	Tetradecanoylphorbol Acetate	84-87	mitogen-activated protein kinase 8	Homo sapiens	193-196
20492175-8	2010	Taken together, these results suggest the antimetastatic effects of acacetin on the TPA-induced A549 cells might be by reducing MMP-2 and u-PA expressions through inhibiting phosphorylation of JNK and reducing NF-kappaB and AP-1 binding activities.	Tetradecanoylphorbol Acetate	84-87	nuclear factor kappa B subunit 1	Homo sapiens	210-219
19910455-6	2010	Whereas TPA or TGF-beta alone stimulated VEGF promoter activity and up-regulated mRNA levels, significant protein secretion was detected only after RA was added to the culture systems.	Tetradecanoylphorbol Acetate	8-11	vascular endothelial growth factor A	Homo sapiens	41-45
19910455-9	2010	Although the precise mechanism(s) of the RA effect remains to be defined, it appears to be mediated by reactive oxygen species; the antioxidant N-acetylcysteine inhibited RA+TPA-stimulated secretion of VEGF by more than 80%.	Tetradecanoylphorbol Acetate	174-177	vascular endothelial growth factor A	Homo sapiens	202-206
19804834-4	2010	Stimulation of intracellular peroxide production by TPA was detected by a DCHF-DA assay, and the addition of superoxide dismutase (SOD) or tempol significantly inhibited TPA-induced migration/invasion and COX-2 protein expression accompanied by a decrease in peroxide production.	Tetradecanoylphorbol Acetate	170-173	superoxide dismutase 1	Homo sapiens	131-134
19804834-4	2010	Stimulation of intracellular peroxide production by TPA was detected by a DCHF-DA assay, and the addition of superoxide dismutase (SOD) or tempol significantly inhibited TPA-induced migration/invasion and COX-2 protein expression accompanied by a decrease in peroxide production.	Tetradecanoylphorbol Acetate	170-173	prostaglandin-endoperoxide synthase 2	Homo sapiens	205-210
20624010-9	2010	Consistent with previous reports phorbol 12-myristate 13-acetate (PMA; 300 nM) induced phosphorylation of VASP at Ser(157), but not Ser(239), which was blocked by general protein kinase C (PKC) inhibitors, Ro31-8220 and Bisindolylmaleimide I (BIM-1), and Go6976, an inhibitor of conventional PKC isoforms.	Tetradecanoylphorbol Acetate	33-64	proline rich transmembrane protein 2	Homo sapiens	171-187
20624010-9	2010	Consistent with previous reports phorbol 12-myristate 13-acetate (PMA; 300 nM) induced phosphorylation of VASP at Ser(157), but not Ser(239), which was blocked by general protein kinase C (PKC) inhibitors, Ro31-8220 and Bisindolylmaleimide I (BIM-1), and Go6976, an inhibitor of conventional PKC isoforms.	Tetradecanoylphorbol Acetate	33-64	proline rich transmembrane protein 2	Homo sapiens	189-192
20624010-9	2010	Consistent with previous reports phorbol 12-myristate 13-acetate (PMA; 300 nM) induced phosphorylation of VASP at Ser(157), but not Ser(239), which was blocked by general protein kinase C (PKC) inhibitors, Ro31-8220 and Bisindolylmaleimide I (BIM-1), and Go6976, an inhibitor of conventional PKC isoforms.	Tetradecanoylphorbol Acetate	33-64	proline rich transmembrane protein 2	Homo sapiens	292-295
20624010-9	2010	Consistent with previous reports phorbol 12-myristate 13-acetate (PMA; 300 nM) induced phosphorylation of VASP at Ser(157), but not Ser(239), which was blocked by general protein kinase C (PKC) inhibitors, Ro31-8220 and Bisindolylmaleimide I (BIM-1), and Go6976, an inhibitor of conventional PKC isoforms.	Tetradecanoylphorbol Acetate	66-69	proline rich transmembrane protein 2	Homo sapiens	171-187
20624010-9	2010	Consistent with previous reports phorbol 12-myristate 13-acetate (PMA; 300 nM) induced phosphorylation of VASP at Ser(157), but not Ser(239), which was blocked by general protein kinase C (PKC) inhibitors, Ro31-8220 and Bisindolylmaleimide I (BIM-1), and Go6976, an inhibitor of conventional PKC isoforms.	Tetradecanoylphorbol Acetate	66-69	proline rich transmembrane protein 2	Homo sapiens	189-192
20624010-9	2010	Consistent with previous reports phorbol 12-myristate 13-acetate (PMA; 300 nM) induced phosphorylation of VASP at Ser(157), but not Ser(239), which was blocked by general protein kinase C (PKC) inhibitors, Ro31-8220 and Bisindolylmaleimide I (BIM-1), and Go6976, an inhibitor of conventional PKC isoforms.	Tetradecanoylphorbol Acetate	66-69	proline rich transmembrane protein 2	Homo sapiens	292-295
19895572-8	2010	PMA treatment also suppressed the surface level of CD98 but not CD29, CD18 and CD147, dose- and time-dependently.	Tetradecanoylphorbol Acetate	0-3	integrin subunit beta 2	Homo sapiens	70-74
20046424-8	2009	Treatment of cancer cells with phorbol 12-myristate 13-acetate increased the expressions of COX-2 and Snail, decreased 15-hydroxyprostaglandin dehydrogenase expression, and increased the cells" motility.	Tetradecanoylphorbol Acetate	31-62	prostaglandin-endoperoxide synthase 2	Homo sapiens	92-97
19148928-3	2009	The phorbol myristate acetate-dependent effects of the material chemistry on cell activation and degradation were evaluated by adding reactive oxygen species scavengers, catalase plus superoxide dismutase to MDM and assaying possible markers of MDM activation: esterase activity, acid phosphatase activity, and high molecular weight group box 1 protein (HMGB1).	Tetradecanoylphorbol Acetate	4-29	catalase	Homo sapiens	170-178
19148928-7	2009	In MDM on HDI, catalase plus superoxide dismutase reduced intracellular HMGB1 levels +/- phorbol myristate acetate; whereas, catalase, superoxide dismutase plus phorbol myristate acetate increased intracellular HMGB1 in MDM on MDI, suggesting that esterase and HMGB1 are more specific markers of activation than acid phosphatase.	Tetradecanoylphorbol Acetate	89-114	catalase	Homo sapiens	15-23
19148928-7	2009	In MDM on HDI, catalase plus superoxide dismutase reduced intracellular HMGB1 levels +/- phorbol myristate acetate; whereas, catalase, superoxide dismutase plus phorbol myristate acetate increased intracellular HMGB1 in MDM on MDI, suggesting that esterase and HMGB1 are more specific markers of activation than acid phosphatase.	Tetradecanoylphorbol Acetate	161-186	catalase	Homo sapiens	125-133
25214955-2	2010	A new drug, mutated recombinant tissue-type plasminogen activator (rtPAm), is the product of mutation of tPA by changing binding loci with plasminogen activator inhibitor (PAI)-1 to reduce the degradation.	Tetradecanoylphorbol Acetate	68-71	plasminogen activator, tissue type	Homo sapiens	32-65
19857463-3	2009	The megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of NRP-1 mRNA and protein expression and by an increase in VEGF-binding activity, which was mainly mediated by VEGFR-2.	Tetradecanoylphorbol Acetate	71-96	thrombopoietin	Homo sapiens	43-46
19857463-3	2009	The megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of NRP-1 mRNA and protein expression and by an increase in VEGF-binding activity, which was mainly mediated by VEGFR-2.	Tetradecanoylphorbol Acetate	71-96	vascular endothelial growth factor A	Homo sapiens	204-208
19857463-3	2009	The megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of NRP-1 mRNA and protein expression and by an increase in VEGF-binding activity, which was mainly mediated by VEGFR-2.	Tetradecanoylphorbol Acetate	98-101	thrombopoietin	Homo sapiens	43-46
19857463-3	2009	The megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of NRP-1 mRNA and protein expression and by an increase in VEGF-binding activity, which was mainly mediated by VEGFR-2.	Tetradecanoylphorbol Acetate	98-101	vascular endothelial growth factor A	Homo sapiens	204-208
20046424-8	2009	Treatment of cancer cells with phorbol 12-myristate 13-acetate increased the expressions of COX-2 and Snail, decreased 15-hydroxyprostaglandin dehydrogenase expression, and increased the cells" motility.	Tetradecanoylphorbol Acetate	31-62	snail family transcriptional repressor 1	Homo sapiens	102-107
19766325-8	2009	Patients with HAM/TSP had a higher p38/ERK ratio (p&lt;0.05) associated with a reduced response to mitogens (phytohaemagglutinin or PMA+ionomycin) (p&lt;0.001) and higher sensitivity to dexamethasone (p&lt;0.05).	Tetradecanoylphorbol Acetate	132-135	thrombospondin 1	Homo sapiens	18-21
20011080-4	2009	To identify the isoform of PKC responsible for the increased progression of the cells through the cell cycle, we monitored the effect of phorbol 12-myristate 13-acetate (PMA) on the subcellular localization of the nine PKC isoforms expressed in RPE cells.	Tetradecanoylphorbol Acetate	137-168	protein kinase C alpha	Homo sapiens	27-30
20011080-4	2009	To identify the isoform of PKC responsible for the increased progression of the cells through the cell cycle, we monitored the effect of phorbol 12-myristate 13-acetate (PMA) on the subcellular localization of the nine PKC isoforms expressed in RPE cells.	Tetradecanoylphorbol Acetate	170-173	protein kinase C alpha	Homo sapiens	27-30
20011080-4	2009	To identify the isoform of PKC responsible for the increased progression of the cells through the cell cycle, we monitored the effect of phorbol 12-myristate 13-acetate (PMA) on the subcellular localization of the nine PKC isoforms expressed in RPE cells.	Tetradecanoylphorbol Acetate	170-173	protein kinase C alpha	Homo sapiens	219-222
20011080-7	2009	Of the nine PKC isoforms that were present in RPE cells, we found PKC(alpha) was both necessary and sufficient to promote cell cycle progression after being stimulated with PMA.	Tetradecanoylphorbol Acetate	173-176	protein kinase C alpha	Homo sapiens	66-76
18691343-2	2009	Intracellular interleukin-4 (Th2 cytokine) and interferon-gamma (Th1 cytokine) production was assessed in CD4+ T lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin using flow cytometry.	Tetradecanoylphorbol Acetate	138-169	interleukin 4	Homo sapiens	14-27
18691343-2	2009	Intracellular interleukin-4 (Th2 cytokine) and interferon-gamma (Th1 cytokine) production was assessed in CD4+ T lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin using flow cytometry.	Tetradecanoylphorbol Acetate	138-169	interferon gamma	Homo sapiens	47-63
18691343-2	2009	Intracellular interleukin-4 (Th2 cytokine) and interferon-gamma (Th1 cytokine) production was assessed in CD4+ T lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin using flow cytometry.	Tetradecanoylphorbol Acetate	138-169	CD4 molecule	Homo sapiens	106-109
19759136-5	2009	p21 induction by other stimuli, such as phorbol myristate acetate and the histone deacetylase inhibitor MS-275, was also associated with preintegrative blocks of HIV-1 replication in macrophages.	Tetradecanoylphorbol Acetate	40-65	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-3
19748482-2	2009	DcR3 was expressed in THP-1 and increased by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	45-76	TNF receptor superfamily member 6b	Homo sapiens	0-4
19769987-5	2009	Although several tumor necrosis factor-alpha- and phorbol-12-myristate-13-acetate/ionomycin-induced NF-kappaB target genes are CARM1 dependent, CARM1 enzymatic activity was dispensable for gene expression.	Tetradecanoylphorbol Acetate	50-81	nuclear factor kappa B subunit 1	Homo sapiens	100-109
19808857-4	2009	We found that MK2(-/-) mice developed significantly fewer skin tumors compared with both TNF-alpha(-/-) and wild-type mice when induced by initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and by promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	215-251	MAP kinase-activated protein kinase 2	Mus musculus	14-17
19808857-4	2009	We found that MK2(-/-) mice developed significantly fewer skin tumors compared with both TNF-alpha(-/-) and wild-type mice when induced by initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and by promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	253-256	MAP kinase-activated protein kinase 2	Mus musculus	14-17
19808857-5	2009	The TPA-induced inflammatory response was reduced in both, TNF-alpha(-/-) mice and MK2(-/-) mice, but most pronounced in TNF-alpha(-/-) mice, indicating that a reduced inflammatory response was not the only explanation for the inhibited tumorigenesis seen in MK2(-/-) mice.	Tetradecanoylphorbol Acetate	4-7	tumor necrosis factor	Mus musculus	59-68
19808857-5	2009	The TPA-induced inflammatory response was reduced in both, TNF-alpha(-/-) mice and MK2(-/-) mice, but most pronounced in TNF-alpha(-/-) mice, indicating that a reduced inflammatory response was not the only explanation for the inhibited tumorigenesis seen in MK2(-/-) mice.	Tetradecanoylphorbol Acetate	4-7	MAP kinase-activated protein kinase 2	Mus musculus	83-86
19808857-5	2009	The TPA-induced inflammatory response was reduced in both, TNF-alpha(-/-) mice and MK2(-/-) mice, but most pronounced in TNF-alpha(-/-) mice, indicating that a reduced inflammatory response was not the only explanation for the inhibited tumorigenesis seen in MK2(-/-) mice.	Tetradecanoylphorbol Acetate	4-7	tumor necrosis factor	Mus musculus	121-130
19808857-5	2009	The TPA-induced inflammatory response was reduced in both, TNF-alpha(-/-) mice and MK2(-/-) mice, but most pronounced in TNF-alpha(-/-) mice, indicating that a reduced inflammatory response was not the only explanation for the inhibited tumorigenesis seen in MK2(-/-) mice.	Tetradecanoylphorbol Acetate	4-7	MAP kinase-activated protein kinase 2	Mus musculus	259-262
19808857-7	2009	This was further supported by: (i) increased levels of the tumor suppressor protein p53 in MK2(-/-) mice after DMBA/TPA treatment compared with controls, (ii) reduced phosphorylation (activation) of the negative p53 regulator, murine double minute 2 in MK2(-)(/-) mouse keratinocytes in vitro and (iii) a significant decrease in the DMBA/TPA induced apoptosis in cultured MK2(-/-) keratinocytes transfected with p53 small interfering RNA.	Tetradecanoylphorbol Acetate	116-119	MAP kinase-activated protein kinase 2	Mus musculus	91-94
19919521-6	2009	Treatment of neutrophils with phorbol myristate acetate (PMA), N-Formyl-Met-Leu-Phe (fMLP) and tumor necrosis factor-alpha (TNF-alpha) induced VEGF release.	Tetradecanoylphorbol Acetate	30-55	vascular endothelial growth factor A	Homo sapiens	143-147
19919521-6	2009	Treatment of neutrophils with phorbol myristate acetate (PMA), N-Formyl-Met-Leu-Phe (fMLP) and tumor necrosis factor-alpha (TNF-alpha) induced VEGF release.	Tetradecanoylphorbol Acetate	57-60	vascular endothelial growth factor A	Homo sapiens	143-147
19760383-7	2009	BITC also inhibited ear edema formation and the protein expression of iNOS and COX-2 in mouse skin treated with TPA.	Tetradecanoylphorbol Acetate	112-115	nitric oxide synthase 2, inducible	Mus musculus	70-74
19855090-3	2009	In contrast, we show here that in these and other cells, IGF-IR overexpression reduced the constitutive and phorbol 12-myristate 13-acetate (PMA)-inducible expression of three protein kinase C (PKC)-regulated metalloproteinases, MMP-3, MMP-9, and MMP-13, in cultured cells as well as in vivo in sc tumors.	Tetradecanoylphorbol Acetate	108-139	insulin-like growth factor I receptor	Mus musculus	57-63
19855090-3	2009	In contrast, we show here that in these and other cells, IGF-IR overexpression reduced the constitutive and phorbol 12-myristate 13-acetate (PMA)-inducible expression of three protein kinase C (PKC)-regulated metalloproteinases, MMP-3, MMP-9, and MMP-13, in cultured cells as well as in vivo in sc tumors.	Tetradecanoylphorbol Acetate	108-139	protein kinase C, alpha	Mus musculus	194-197
19855090-3	2009	In contrast, we show here that in these and other cells, IGF-IR overexpression reduced the constitutive and phorbol 12-myristate 13-acetate (PMA)-inducible expression of three protein kinase C (PKC)-regulated metalloproteinases, MMP-3, MMP-9, and MMP-13, in cultured cells as well as in vivo in sc tumors.	Tetradecanoylphorbol Acetate	141-144	insulin-like growth factor I receptor	Mus musculus	57-63
19855090-3	2009	In contrast, we show here that in these and other cells, IGF-IR overexpression reduced the constitutive and phorbol 12-myristate 13-acetate (PMA)-inducible expression of three protein kinase C (PKC)-regulated metalloproteinases, MMP-3, MMP-9, and MMP-13, in cultured cells as well as in vivo in sc tumors.	Tetradecanoylphorbol Acetate	141-144	protein kinase C, alpha	Mus musculus	194-197
19748482-2	2009	DcR3 was expressed in THP-1 and increased by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	78-81	TNF receptor superfamily member 6b	Homo sapiens	0-4
19766325-8	2009	Patients with HAM/TSP had a higher p38/ERK ratio (p&lt;0.05) associated with a reduced response to mitogens (phytohaemagglutinin or PMA+ionomycin) (p&lt;0.001) and higher sensitivity to dexamethasone (p&lt;0.05).	Tetradecanoylphorbol Acetate	132-135	mitogen-activated protein kinase 14	Homo sapiens	35-38
19824668-2	2009	Here we report on the in vitro and in vivo immunostimulatory capabilities of LbL-assembled disulfide cross-linked poly(methacrylic acid) (PMA(SH)) hydrogel capsules as a delivery strategy for protein and peptide vaccines using robust transgenic mice models and ovalbumin (OVA) as a model vaccine.	Tetradecanoylphorbol Acetate	138-141	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	261-270
19765582-5	2009	Administration of a PKC activator, phorbol 12-myristate 13-acetate (PMA), concentration-dependently increased the alpha-secretase cleavage products, and reduced the BACE-1 cleavage products.	Tetradecanoylphorbol Acetate	35-66	proline rich transmembrane protein 2	Homo sapiens	20-23
19765582-5	2009	Administration of a PKC activator, phorbol 12-myristate 13-acetate (PMA), concentration-dependently increased the alpha-secretase cleavage products, and reduced the BACE-1 cleavage products.	Tetradecanoylphorbol Acetate	35-66	beta-secretase 1	Homo sapiens	165-171
19765582-5	2009	Administration of a PKC activator, phorbol 12-myristate 13-acetate (PMA), concentration-dependently increased the alpha-secretase cleavage products, and reduced the BACE-1 cleavage products.	Tetradecanoylphorbol Acetate	68-71	proline rich transmembrane protein 2	Homo sapiens	20-23
19765582-5	2009	Administration of a PKC activator, phorbol 12-myristate 13-acetate (PMA), concentration-dependently increased the alpha-secretase cleavage products, and reduced the BACE-1 cleavage products.	Tetradecanoylphorbol Acetate	68-71	beta-secretase 1	Homo sapiens	165-171
19765582-6	2009	In addition, the inhibition of PKC prevented PMA- or bis(7)-Cognitin-induced alterations in alpha-secretase and BACE-1 activities, eliminating reductions in Abeta production seen with PMA or the dimer.	Tetradecanoylphorbol Acetate	45-48	proline rich transmembrane protein 2	Homo sapiens	31-34
19765582-6	2009	In addition, the inhibition of PKC prevented PMA- or bis(7)-Cognitin-induced alterations in alpha-secretase and BACE-1 activities, eliminating reductions in Abeta production seen with PMA or the dimer.	Tetradecanoylphorbol Acetate	45-48	beta-secretase 1	Homo sapiens	112-118
19765582-6	2009	In addition, the inhibition of PKC prevented PMA- or bis(7)-Cognitin-induced alterations in alpha-secretase and BACE-1 activities, eliminating reductions in Abeta production seen with PMA or the dimer.	Tetradecanoylphorbol Acetate	184-187	proline rich transmembrane protein 2	Homo sapiens	31-34
19824668-2	2009	Here we report on the in vitro and in vivo immunostimulatory capabilities of LbL-assembled disulfide cross-linked poly(methacrylic acid) (PMA(SH)) hydrogel capsules as a delivery strategy for protein and peptide vaccines using robust transgenic mice models and ovalbumin (OVA) as a model vaccine.	Tetradecanoylphorbol Acetate	138-141	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	272-275
19907654-4	2009	We provide evidence for decreased DNA fragmentation, reduced mitochondrial membrane depolarization, impaired reactive oxygen species production, diminished cytochrome c release and increased IL-6 production compared to healthy subjects after PMA exposure.	Tetradecanoylphorbol Acetate	242-245	cytochrome c, somatic	Homo sapiens	156-168
19747485-4	2009	Phorbol 12-myristate 13-acetate (PMA) treatment substantially increased TPalpha mRNA and Prm1-directed gene expression in human erythroleukemia and K562 cells.	Tetradecanoylphorbol Acetate	0-31	plasminogen activator, tissue type	Homo sapiens	72-79
19747485-4	2009	Phorbol 12-myristate 13-acetate (PMA) treatment substantially increased TPalpha mRNA and Prm1-directed gene expression in human erythroleukemia and K562 cells.	Tetradecanoylphorbol Acetate	0-31	protamine 1	Homo sapiens	89-93
19747485-4	2009	Phorbol 12-myristate 13-acetate (PMA) treatment substantially increased TPalpha mRNA and Prm1-directed gene expression in human erythroleukemia and K562 cells.	Tetradecanoylphorbol Acetate	33-36	plasminogen activator, tissue type	Homo sapiens	72-79
19747485-4	2009	Phorbol 12-myristate 13-acetate (PMA) treatment substantially increased TPalpha mRNA and Prm1-directed gene expression in human erythroleukemia and K562 cells.	Tetradecanoylphorbol Acetate	33-36	protamine 1	Homo sapiens	89-93
19715751-0	2009	Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells.	Tetradecanoylphorbol Acetate	19-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	70-75
19715751-2	2009	In a previous study, we reported that silibinin suppresses TPA-induced MMP-9 expression through the Raf/MEK/ERK pathway.	Tetradecanoylphorbol Acetate	59-62	mitogen-activated protein kinase kinase 7	Homo sapiens	104-107
19715751-2	2009	In a previous study, we reported that silibinin suppresses TPA-induced MMP-9 expression through the Raf/MEK/ERK pathway.	Tetradecanoylphorbol Acetate	59-62	mitogen-activated protein kinase 1	Homo sapiens	108-111
19715751-3	2009	AIMS OF THE STUDY: Herein we determined the co-relationship between MMP-9 and COX-2, as well as the effect of silibinin on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 and COX-2 expression in the human breast cancer cells, MCF-7 and MDA-MB231.	Tetradecanoylphorbol Acetate	123-160	prostaglandin-endoperoxide synthase 2	Homo sapiens	185-190
19715751-7	2009	RESULTS: The expression of MMP-9 and COX-2 in response to TPA was increased, whereas TPA-induced MMP-9 and COX-2 expression was decreased by silibinin.	Tetradecanoylphorbol Acetate	58-61	prostaglandin-endoperoxide synthase 2	Homo sapiens	37-42
19715751-7	2009	RESULTS: The expression of MMP-9 and COX-2 in response to TPA was increased, whereas TPA-induced MMP-9 and COX-2 expression was decreased by silibinin.	Tetradecanoylphorbol Acetate	85-88	prostaglandin-endoperoxide synthase 2	Homo sapiens	107-112
19715751-10	2009	In contrast, TPA-induced MMP-9 and COX-2 expression was decreased by UO126 (MEK 1/2 inhibitor).	Tetradecanoylphorbol Acetate	13-16	prostaglandin-endoperoxide synthase 2	Homo sapiens	35-40
19715751-11	2009	CONCLUSION: Silibinin down-regulates TPA-induced MMP-9 expression through inhibition of COX-2 expression in breast cancer cells.	Tetradecanoylphorbol Acetate	37-40	prostaglandin-endoperoxide synthase 2	Homo sapiens	88-93
19907654-4	2009	We provide evidence for decreased DNA fragmentation, reduced mitochondrial membrane depolarization, impaired reactive oxygen species production, diminished cytochrome c release and increased IL-6 production compared to healthy subjects after PMA exposure.	Tetradecanoylphorbol Acetate	242-245	interleukin 6	Homo sapiens	191-195
19591805-3	2009	B1 and B2, inhibited tumor necrosis factor alpha (TNFalpha)- and phorbol 12-myristate 13-acetate (PMA)-induced transactivation of NF-kappaB-driven genes and the increase of NF-kappaB-DNA nuclear binding in Jurkat T cells.	Tetradecanoylphorbol Acetate	65-96	nuclear factor kappa B subunit 1	Homo sapiens	130-139
19887187-5	2009	In phorbol myristate acetate-differentiated THP-1 macrophages, pressure stimulated beta(1)-integrin T788/789 phosphorylation, but not S785 phosphorylation.	Tetradecanoylphorbol Acetate	3-28	GLI family zinc finger 2	Homo sapiens	44-49
19824632-7	2009	It was found that the TPA cross sections are extremely sensitive to the concentration with the greatest TPA cross-section of 1.0 x 10(-45) cm(4) s photon(-1) molecule(-1) for C(70)-TCTA measured in the low concentration regime ( approximately 10(-5) M).	Tetradecanoylphorbol Acetate	22-25	T cell leukemia translocation altered	Homo sapiens	181-185
19824632-7	2009	It was found that the TPA cross sections are extremely sensitive to the concentration with the greatest TPA cross-section of 1.0 x 10(-45) cm(4) s photon(-1) molecule(-1) for C(70)-TCTA measured in the low concentration regime ( approximately 10(-5) M).	Tetradecanoylphorbol Acetate	104-107	T cell leukemia translocation altered	Homo sapiens	181-185
19591805-3	2009	B1 and B2, inhibited tumor necrosis factor alpha (TNFalpha)- and phorbol 12-myristate 13-acetate (PMA)-induced transactivation of NF-kappaB-driven genes and the increase of NF-kappaB-DNA nuclear binding in Jurkat T cells.	Tetradecanoylphorbol Acetate	65-96	nuclear factor kappa B subunit 1	Homo sapiens	173-182
19591805-3	2009	B1 and B2, inhibited tumor necrosis factor alpha (TNFalpha)- and phorbol 12-myristate 13-acetate (PMA)-induced transactivation of NF-kappaB-driven genes and the increase of NF-kappaB-DNA nuclear binding in Jurkat T cells.	Tetradecanoylphorbol Acetate	98-101	nuclear factor kappa B subunit 1	Homo sapiens	130-139
19591805-3	2009	B1 and B2, inhibited tumor necrosis factor alpha (TNFalpha)- and phorbol 12-myristate 13-acetate (PMA)-induced transactivation of NF-kappaB-driven genes and the increase of NF-kappaB-DNA nuclear binding in Jurkat T cells.	Tetradecanoylphorbol Acetate	98-101	nuclear factor kappa B subunit 1	Homo sapiens	173-182
19586612-3	2009	Here we show that endosomes and proteasome cooperate in phorbol ester 12-O-tetradecanoyl phorbol acetate (TPA)-induced down-regulation of PKC alpha.	Tetradecanoylphorbol Acetate	70-104	protein kinase C alpha	Homo sapiens	138-147
19632320-1	2009	Here we demonstrate that elevation of cyclic AMP (cAMP) levels in human umbilical vein endothelial cells (HUVECs) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-alpha/IL-6 (sIL-6R alpha/IL-6) trans-signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	315-346	cathelicidin antimicrobial peptide	Homo sapiens	50-54
19632320-1	2009	Here we demonstrate that elevation of cyclic AMP (cAMP) levels in human umbilical vein endothelial cells (HUVECs) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-alpha/IL-6 (sIL-6R alpha/IL-6) trans-signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	315-346	mitogen-activated protein kinase 3	Homo sapiens	138-144
19586612-3	2009	Here we show that endosomes and proteasome cooperate in phorbol ester 12-O-tetradecanoyl phorbol acetate (TPA)-induced down-regulation of PKC alpha.	Tetradecanoylphorbol Acetate	106-109	protein kinase C alpha	Homo sapiens	138-147
19586612-4	2009	We show that following TPA treatment and translocation to the plasma membrane, PKC alpha undergoes multimonoubiquitination prior to its degradation by the proteasome.	Tetradecanoylphorbol Acetate	23-26	protein kinase C alpha	Homo sapiens	79-88
21305155-4	2009	In the present work, human monocyte cell line THP-1 was induced with phorbol myristate acetate to differentiate into a macrophage.	Tetradecanoylphorbol Acetate	69-94	GLI family zinc finger 2	Homo sapiens	46-51
19576886-12	2009	PMA (10nM) mimicked the effect of ET-1.	Tetradecanoylphorbol Acetate	0-3	endothelin 1	Rattus norvegicus	34-38
19887558-5	2009	Cotreatment with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, dramatically inhibited the HDACi-mediated increase in FADD recruitment and sensitization to TRAIL-induced apoptosis and both of these were reversed by PKC inhibitors.	Tetradecanoylphorbol Acetate	17-48	TNF superfamily member 10	Homo sapiens	184-189
19887558-5	2009	Cotreatment with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, dramatically inhibited the HDACi-mediated increase in FADD recruitment and sensitization to TRAIL-induced apoptosis and both of these were reversed by PKC inhibitors.	Tetradecanoylphorbol Acetate	50-53	TNF superfamily member 10	Homo sapiens	184-189
19526458-5	2009	Hepatic leukemia factor (HLF) and D-site albumin promoter-binding protein (DBP) were increased in both bFGF and TPA soft agar colonies and selected for functional validation.	Tetradecanoylphorbol Acetate	112-115	D-box binding PAR bZIP transcription factor	Homo sapiens	34-73
19526458-5	2009	Hepatic leukemia factor (HLF) and D-site albumin promoter-binding protein (DBP) were increased in both bFGF and TPA soft agar colonies and selected for functional validation.	Tetradecanoylphorbol Acetate	112-115	D-box binding PAR bZIP transcription factor	Homo sapiens	75-78
19526458-6	2009	Ectopic expression of human HLF and DBP in JB6 cells resulted in a marked increase in TPA- and bFGF-regulated AIG responses.	Tetradecanoylphorbol Acetate	86-89	D-box binding PAR bZIP transcription factor	Homo sapiens	36-39
19526458-8	2009	Subsequent biological network analysis suggests that many of the differentially expressed genes that are common to bFGF- and TPA-dependent AIG are regulated by c-Myc, SP-1, and HNF-4 transcription factors.	Tetradecanoylphorbol Acetate	125-128	fibroblast growth factor 2	Homo sapiens	115-119
19526458-8	2009	Subsequent biological network analysis suggests that many of the differentially expressed genes that are common to bFGF- and TPA-dependent AIG are regulated by c-Myc, SP-1, and HNF-4 transcription factors.	Tetradecanoylphorbol Acetate	125-128	hepatocyte nuclear factor 4 alpha	Homo sapiens	177-182
19887558-6	2009	Thus, enhanced FADD recruitment is a critical step in HDACi-mediated sensitization of CLL cells to TRAIL-induced apoptosis and this step is differentially affected by HDACi and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	177-208	TNF superfamily member 10	Homo sapiens	99-104
19706284-0	2009	PMA induces expression from the herpes simplex virus thymidine kinase promoter via the activation of JNK and ERK in the presence of adenoviral E1A proteins.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	101-104
20166549-4	2009	Phorbol 12-myristate 13-acetate (PMA) is known as PKC activator, significantly enhanced the c-mpl promoter activity and PKC inhibitors (H7, GF109203) suppressed the up-regulation of PMA-induced promoter activity and reduced the steady level of its activity.	Tetradecanoylphorbol Acetate	0-31	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	92-97
20166549-4	2009	Phorbol 12-myristate 13-acetate (PMA) is known as PKC activator, significantly enhanced the c-mpl promoter activity and PKC inhibitors (H7, GF109203) suppressed the up-regulation of PMA-induced promoter activity and reduced the steady level of its activity.	Tetradecanoylphorbol Acetate	33-36	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	92-97
19683044-2	2009	AIMS OF THE STUDY: The purpose of the present study is to determine whether the ethanol (EtOH) extract of GSL regulates the inflammatory reaction stimulated by phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI) in human mast cells (HMC-1).	Tetradecanoylphorbol Acetate	160-191	cathepsin A	Homo sapiens	106-109
19667069-2	2009	Treatment of LNCaP prostate cancer cells with phorbol 12-myristate 13-acetate (PMA) causes a strong and sustained activation of RhoA and its downstream effector ROCK (Rho kinase) as well as the formation of stress fibers.	Tetradecanoylphorbol Acetate	46-77	ras homolog family member A	Homo sapiens	128-132
19667069-2	2009	Treatment of LNCaP prostate cancer cells with phorbol 12-myristate 13-acetate (PMA) causes a strong and sustained activation of RhoA and its downstream effector ROCK (Rho kinase) as well as the formation of stress fibers.	Tetradecanoylphorbol Acetate	79-82	ras homolog family member A	Homo sapiens	128-132
20137333-3	2009	The differentiation of THP-1 cells into macrophages was induced by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	67-98	GLI family zinc finger 2	Homo sapiens	23-28
19755418-0	2009	12-O-tetradecanoylphorbol-13-acetate inhibits melanoma growth by inactivation of STAT3 through protein kinase C-activated tyrosine phosphatase(s).	Tetradecanoylphorbol Acetate	0-36	signal transducer and activator of transcription 3	Homo sapiens	81-86
19755418-2	2009	In this study, the involvement of the signal transducer and activator of transcription 3 (STAT3) in the TPA-induced growth inhibition of melanoma cells was examined.	Tetradecanoylphorbol Acetate	104-107	signal transducer and activator of transcription 3	Homo sapiens	38-88
19755418-2	2009	In this study, the involvement of the signal transducer and activator of transcription 3 (STAT3) in the TPA-induced growth inhibition of melanoma cells was examined.	Tetradecanoylphorbol Acetate	104-107	signal transducer and activator of transcription 3	Homo sapiens	90-95
19755418-3	2009	The in vitro growth and DNA synthesis of five melanoma cell lines, whose STAT3 was activated (phosphorylated), was inhibited by TPA, whereas that of WM35 and WM39 cells, whose STAT3 activity was at negligible levels, was considerably slow and not affected by TPA.	Tetradecanoylphorbol Acetate	128-131	signal transducer and activator of transcription 3	Homo sapiens	73-78
19755418-5	2009	Treatment of WM1205Lu cells with TPA decreased both the phosphorylated STAT3 and the DNA-binding activity of STAT3.	Tetradecanoylphorbol Acetate	33-36	signal transducer and activator of transcription 3	Homo sapiens	71-76
19755418-5	2009	Treatment of WM1205Lu cells with TPA decreased both the phosphorylated STAT3 and the DNA-binding activity of STAT3.	Tetradecanoylphorbol Acetate	33-36	signal transducer and activator of transcription 3	Homo sapiens	109-114
19755418-6	2009	Pretreatment of WM1205Lu cells with either a protein-tyrosine phosphatase inhibitor or a protein kinase C (PKC) inhibitor prevented the inhibitory effects of TPA on the level of phosphorylated STAT3.	Tetradecanoylphorbol Acetate	158-161	protein kinase C alpha	Homo sapiens	107-110
19755418-6	2009	Pretreatment of WM1205Lu cells with either a protein-tyrosine phosphatase inhibitor or a protein kinase C (PKC) inhibitor prevented the inhibitory effects of TPA on the level of phosphorylated STAT3.	Tetradecanoylphorbol Acetate	158-161	signal transducer and activator of transcription 3	Homo sapiens	193-198
19755418-8	2009	Introduction of the dominant negative mutant of one of these PKC isoforms into WM1205Lu cells inhibited the TPA-induced dephosphorylation of STAT3.	Tetradecanoylphorbol Acetate	108-111	protein kinase C alpha	Homo sapiens	61-64
19755418-8	2009	Introduction of the dominant negative mutant of one of these PKC isoforms into WM1205Lu cells inhibited the TPA-induced dephosphorylation of STAT3.	Tetradecanoylphorbol Acetate	108-111	signal transducer and activator of transcription 3	Homo sapiens	141-146
19755418-11	2009	Because TPA did not affect c-Src activity, we conclude that the growth inhibitory effect of TPA on melanoma cells is mediated through inactivation of STAT3 by a PKC-activated tyrosine phosphatase(s).	Tetradecanoylphorbol Acetate	92-95	signal transducer and activator of transcription 3	Homo sapiens	150-155
19755418-11	2009	Because TPA did not affect c-Src activity, we conclude that the growth inhibitory effect of TPA on melanoma cells is mediated through inactivation of STAT3 by a PKC-activated tyrosine phosphatase(s).	Tetradecanoylphorbol Acetate	92-95	protein kinase C alpha	Homo sapiens	161-164
19706284-0	2009	PMA induces expression from the herpes simplex virus thymidine kinase promoter via the activation of JNK and ERK in the presence of adenoviral E1A proteins.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	109-112
19738054-4	2009	Targeted disruption of Stat3 in bulge region KSCs at the time of initiation also dramatically reduced the number of skin tumors (by approximately 80%) produced following promotion with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	203-239	signal transducer and activator of transcription 3	Mus musculus	23-28
19787145-3	2009	NIH 3T3 cells were treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce endogenous mPer2 expression or transfected with pcDNA3.1(+)-mPer2 and irradiated with 60Co-gamma-rays, and then analyzed by several methods such as flow cytometry, colony formation assay, RT-PCR, and immunohistochemistry.	Tetradecanoylphorbol Acetate	32-68	period circadian clock 2	Mus musculus	96-101
19787145-3	2009	NIH 3T3 cells were treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce endogenous mPer2 expression or transfected with pcDNA3.1(+)-mPer2 and irradiated with 60Co-gamma-rays, and then analyzed by several methods such as flow cytometry, colony formation assay, RT-PCR, and immunohistochemistry.	Tetradecanoylphorbol Acetate	70-73	period circadian clock 2	Mus musculus	96-101
19787145-4	2009	Flow cytometry and colony formation assay revealed that irradiated NIH 3T3 cells expressing high levels of mPer2 showed a lower death rate (TPA: 24 h 4.3% vs 12 h 6.8% and control 9.4%; transfection: pcDNA3.1-mPer2 3.7% vs pcDNA3.1 11.3% and control 8.2%), more proliferation and clonogenic survival (TPA: 121.7 +/- 6.51 vs 66.0 +/- 3.51 and 67.7 +/- 7.37; transfection: 121.7 +/- 6.50 vs 65.3 +/- 3.51 and 69.0 +/- 4.58) both when treated with TPA and transfected with mPer2.	Tetradecanoylphorbol Acetate	140-143	period circadian clock 2	Mus musculus	107-112
19789299-8	2009	Using Western blotting and immunohistochemical staining with phosphospecific antibodies, we show that coadministration of ATRA suppressed the 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation of Stat3 in both models, but was only able to suppress tumor formation in the SENCAR mice.	Tetradecanoylphorbol Acetate	142-178	signal transducer and activator of transcription 3	Mus musculus	206-211
19661060-4	2009	TRPV4 channel activation and serine phosphorylation were enhanced by exposure to the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate or by application of bradykinin, which activates PKC via a G-protein-coupled mechanism.	Tetradecanoylphorbol Acetate	118-149	proline rich transmembrane protein 2	Homo sapiens	85-101
19661060-4	2009	TRPV4 channel activation and serine phosphorylation were enhanced by exposure to the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate or by application of bradykinin, which activates PKC via a G-protein-coupled mechanism.	Tetradecanoylphorbol Acetate	118-149	proline rich transmembrane protein 2	Homo sapiens	103-106
19661060-4	2009	TRPV4 channel activation and serine phosphorylation were enhanced by exposure to the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate or by application of bradykinin, which activates PKC via a G-protein-coupled mechanism.	Tetradecanoylphorbol Acetate	118-149	proline rich transmembrane protein 2	Homo sapiens	199-202
19907102-4	2009	PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p&lt;0.05) in THP-1 cells.	Tetradecanoylphorbol Acetate	0-3	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	29-34
19564157-4	2009	Here, we report that PAD2 is expressed in human monocytic leukaemia THP-1 cells during differentiation into macrophages by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	123-159	GLI family zinc finger 2	Homo sapiens	68-73
19656660-13	2009	In addition, the GS-HCl-mediated COX-2 protein modification was observed in both endogenous and PMA-induced COX-2 in HaCaT cells.	Tetradecanoylphorbol Acetate	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
19656660-13	2009	In addition, the GS-HCl-mediated COX-2 protein modification was observed in both endogenous and PMA-induced COX-2 in HaCaT cells.	Tetradecanoylphorbol Acetate	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
19656660-14	2009	CONCLUSIONS: GS-HCl differentially down-regulates COX-2 and MMP-13 expression in the IL-1beta- or PMA-treated human skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively.	Tetradecanoylphorbol Acetate	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
19656660-14	2009	CONCLUSIONS: GS-HCl differentially down-regulates COX-2 and MMP-13 expression in the IL-1beta- or PMA-treated human skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively.	Tetradecanoylphorbol Acetate	98-101	matrix metallopeptidase 13	Homo sapiens	60-66
19656660-14	2009	CONCLUSIONS: GS-HCl differentially down-regulates COX-2 and MMP-13 expression in the IL-1beta- or PMA-treated human skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively.	Tetradecanoylphorbol Acetate	98-101	mitogen-activated protein kinase 14	Homo sapiens	141-144
19656660-14	2009	CONCLUSIONS: GS-HCl differentially down-regulates COX-2 and MMP-13 expression in the IL-1beta- or PMA-treated human skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively.	Tetradecanoylphorbol Acetate	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
19907102-2	2009	METHODS: The present study focused on the effect of VPP on monocyte adhesion to endothelium under flow conditions using phorbol 12-myristate 13-acetate (PMA)-stimulated monocytic THP-1 cells.	Tetradecanoylphorbol Acetate	120-151	GLI family zinc finger 2	Homo sapiens	179-184
19907102-2	2009	METHODS: The present study focused on the effect of VPP on monocyte adhesion to endothelium under flow conditions using phorbol 12-myristate 13-acetate (PMA)-stimulated monocytic THP-1 cells.	Tetradecanoylphorbol Acetate	153-156	GLI family zinc finger 2	Homo sapiens	179-184
19907102-4	2009	PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p&lt;0.05) in THP-1 cells.	Tetradecanoylphorbol Acetate	0-3	GLI family zinc finger 2	Homo sapiens	68-73
19907102-3	2009	RESULTS: Pre-incubation of THP-1 cells with VPP (1 mM, 24 hours) significantly decreased the PMA-induced adhesion of THP-1 cells (p&lt;0.05) to human umbilical vein endothelial cells (HUVECs).	Tetradecanoylphorbol Acetate	93-96	GLI family zinc finger 2	Homo sapiens	27-32
19907102-3	2009	RESULTS: Pre-incubation of THP-1 cells with VPP (1 mM, 24 hours) significantly decreased the PMA-induced adhesion of THP-1 cells (p&lt;0.05) to human umbilical vein endothelial cells (HUVECs).	Tetradecanoylphorbol Acetate	93-96	GLI family zinc finger 2	Homo sapiens	117-122
20177957-0	2009	Specific subcellular targeting of PKCalpha and PKCepsilon in normal and tumoral lactotroph cells by PMA-mitogenic stimulus.	Tetradecanoylphorbol Acetate	100-103	protein kinase C alpha	Homo sapiens	34-42
19907102-4	2009	PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p&lt;0.05) in THP-1 cells.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	177-180
19907102-4	2009	PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p&lt;0.05) in THP-1 cells.	Tetradecanoylphorbol Acetate	0-3	GLI family zinc finger 2	Homo sapiens	196-201
19907102-4	2009	PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p&lt;0.05) in THP-1 cells.	Tetradecanoylphorbol Acetate	146-149	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	29-34
19907102-4	2009	PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p&lt;0.05) in THP-1 cells.	Tetradecanoylphorbol Acetate	146-149	GLI family zinc finger 2	Homo sapiens	68-73
19907102-4	2009	PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p&lt;0.05) in THP-1 cells.	Tetradecanoylphorbol Acetate	146-149	mitogen-activated protein kinase 8	Homo sapiens	177-180
19907102-4	2009	PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p&lt;0.05) in THP-1 cells.	Tetradecanoylphorbol Acetate	146-149	GLI family zinc finger 2	Homo sapiens	196-201
19907102-5	2009	In addition, preincubation of THP-1 with SP600125, a specific inhibitor of JNK, resulted in significant reduction of the PMA-induced adhesion of THP-1.	Tetradecanoylphorbol Acetate	121-124	GLI family zinc finger 2	Homo sapiens	30-35
19907102-5	2009	In addition, preincubation of THP-1 with SP600125, a specific inhibitor of JNK, resulted in significant reduction of the PMA-induced adhesion of THP-1.	Tetradecanoylphorbol Acetate	121-124	mitogen-activated protein kinase 8	Homo sapiens	75-78
19907102-5	2009	In addition, preincubation of THP-1 with SP600125, a specific inhibitor of JNK, resulted in significant reduction of the PMA-induced adhesion of THP-1.	Tetradecanoylphorbol Acetate	121-124	GLI family zinc finger 2	Homo sapiens	145-150
19783865-3	2009	Treatment with EGF and 4beta-phorbol 12-myristate 13-acetate (PMA) with A23187 released AA accompanied by the phosphorylation of extracellular signal-regulated kinases (ERK1/2).	Tetradecanoylphorbol Acetate	62-65	mitogen-activated protein kinase 3	Homo sapiens	169-175
19783865-3	2009	Treatment with EGF and 4beta-phorbol 12-myristate 13-acetate (PMA) with A23187 released AA accompanied by the phosphorylation of extracellular signal-regulated kinases (ERK1/2).	Tetradecanoylphorbol Acetate	23-60	mitogen-activated protein kinase 3	Homo sapiens	169-175
19783865-6	2009	Co-treatment with sorafenib and an inhibitor of Src family members additionally inhibited the PMA-induced release of AA.	Tetradecanoylphorbol Acetate	94-97	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	48-51
19394719-2	2009	These derivatives enhance TNF-alpha production using human leukemia HL-60 cells induced with 12-O-tetradecanoylphorbol 13-acetate (TPA), while inhibiting TNF-alpha production induced with okadaic acid (OA) in the same cell line.	Tetradecanoylphorbol Acetate	93-129	tumor necrosis factor	Homo sapiens	26-35
19725963-6	2009	Furthermore, using human cord blood-derived CD34+ cells we identified a HIR in a similar region as the TPA-Mat T cell line.	Tetradecanoylphorbol Acetate	103-106	CD34 molecule	Homo sapiens	44-48
19343040-6	2009	The phosphorylation of this residue is operated by the protein kinase C (PKC), as S193 phosphorylation is markedly increased by treatment with 12-O-tetradecanoylphorbol-13-acetate and decreased by inhibition of PKCalpha and PKCbeta.	Tetradecanoylphorbol Acetate	143-179	protein kinase C alpha	Homo sapiens	73-76
19343040-6	2009	The phosphorylation of this residue is operated by the protein kinase C (PKC), as S193 phosphorylation is markedly increased by treatment with 12-O-tetradecanoylphorbol-13-acetate and decreased by inhibition of PKCalpha and PKCbeta.	Tetradecanoylphorbol Acetate	143-179	protein kinase C alpha	Homo sapiens	211-219
19536794-7	2009	Epidermal growth factor (EGF), phorbol 12-myristate 13-acetate (PMA), LPA, and S1P induce activation of Erks in PC-3 and Du145; only EGF and PMA activate Erks in LNCaP.	Tetradecanoylphorbol Acetate	31-62	mitogen-activated protein kinase 1	Homo sapiens	104-108
19536794-7	2009	Epidermal growth factor (EGF), phorbol 12-myristate 13-acetate (PMA), LPA, and S1P induce activation of Erks in PC-3 and Du145; only EGF and PMA activate Erks in LNCaP.	Tetradecanoylphorbol Acetate	31-62	mitogen-activated protein kinase 1	Homo sapiens	154-158
19536794-7	2009	Epidermal growth factor (EGF), phorbol 12-myristate 13-acetate (PMA), LPA, and S1P induce activation of Erks in PC-3 and Du145; only EGF and PMA activate Erks in LNCaP.	Tetradecanoylphorbol Acetate	64-67	mitogen-activated protein kinase 1	Homo sapiens	104-108
19536794-7	2009	Epidermal growth factor (EGF), phorbol 12-myristate 13-acetate (PMA), LPA, and S1P induce activation of Erks in PC-3 and Du145; only EGF and PMA activate Erks in LNCaP.	Tetradecanoylphorbol Acetate	64-67	mitogen-activated protein kinase 1	Homo sapiens	154-158
19573594-4	2009	Retinoic acid (RA) and 12-O-tetradecanoylphorbol 13-acetate, two well-studied inducers of neuronal differentiation, are able to induce Nrf2 and its target gene NAD(P)H quinone oxidoreductase 1 in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	23-59	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
19573594-4	2009	Retinoic acid (RA) and 12-O-tetradecanoylphorbol 13-acetate, two well-studied inducers of neuronal differentiation, are able to induce Nrf2 and its target gene NAD(P)H quinone oxidoreductase 1 in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	23-59	NAD(P)H quinone dehydrogenase 1	Homo sapiens	160-192
19460777-3	2009	METHODS AND RESULTS: Human saphenous vein VSMC were exposed to phorbol 12-myristate 13-acetate (PMA) to induce endogenous cyclooxygenase-2-dependent prostaglandin generation.	Tetradecanoylphorbol Acetate	63-94	prostaglandin-endoperoxide synthase 2	Homo sapiens	122-138
19460777-3	2009	METHODS AND RESULTS: Human saphenous vein VSMC were exposed to phorbol 12-myristate 13-acetate (PMA) to induce endogenous cyclooxygenase-2-dependent prostaglandin generation.	Tetradecanoylphorbol Acetate	96-99	prostaglandin-endoperoxide synthase 2	Homo sapiens	122-138
19394719-2	2009	These derivatives enhance TNF-alpha production using human leukemia HL-60 cells induced with 12-O-tetradecanoylphorbol 13-acetate (TPA), while inhibiting TNF-alpha production induced with okadaic acid (OA) in the same cell line.	Tetradecanoylphorbol Acetate	131-134	tumor necrosis factor	Homo sapiens	26-35
19639210-6	2009	The inhibitors against NF-kappaB and mitogen-activated protein kinases (MAP kinase) including ERK and JNK pathways suppressed TPA-induced luciferase activity of MMP-1, -3 and -7 promoters.	Tetradecanoylphorbol Acetate	126-129	mitogen-activated protein kinase 1	Homo sapiens	94-97
19553475-5	2009	32P-labeling demonstrated direct phosphorylation of TRPV1 or TRPV1t in anterior lingual epithelium by PMA, cyclosporin A, or FK-506.	Tetradecanoylphorbol Acetate	102-105	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	52-57
19553475-5	2009	32P-labeling demonstrated direct phosphorylation of TRPV1 or TRPV1t in anterior lingual epithelium by PMA, cyclosporin A, or FK-506.	Tetradecanoylphorbol Acetate	102-105	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	61-66
19776509-3	2009	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated PGE(2) release and COX-2 mRNA expression, as shown in human gingival fibroblasts stimulated by IL-1beta.	Tetradecanoylphorbol Acetate	18-49	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-91
19776509-3	2009	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated PGE(2) release and COX-2 mRNA expression, as shown in human gingival fibroblasts stimulated by IL-1beta.	Tetradecanoylphorbol Acetate	18-49	interleukin 1 beta	Homo sapiens	162-170
19776509-3	2009	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated PGE(2) release and COX-2 mRNA expression, as shown in human gingival fibroblasts stimulated by IL-1beta.	Tetradecanoylphorbol Acetate	51-54	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-91
19776509-3	2009	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated PGE(2) release and COX-2 mRNA expression, as shown in human gingival fibroblasts stimulated by IL-1beta.	Tetradecanoylphorbol Acetate	51-54	interleukin 1 beta	Homo sapiens	162-170
19776509-5	2009	In cells in which PMA-dependent PKC was down-regulated, PMA failed to induce the formation of NFkappaB DNA-protein complex and reduced the release of PMA-induced PGE(2), whereas IL-1beta stimulated the formation of COX-2-NFkappaB DNA-protein complex and PGE(2) release.	Tetradecanoylphorbol Acetate	18-21	interleukin 1 beta	Homo sapiens	178-186
19694614-5	2009	In vitro studies using phorbol 12-myristyl 13-acetate (PMA) stimulated macrophage-like THP-1 (mTHP-1) cells were focused on cytotoxicity of both polymers and particles, and their potential to stimulate IL-8 release via the TLR-2 pathway.	Tetradecanoylphorbol Acetate	55-58	GLI family zinc finger 2	Homo sapiens	87-92
19694614-5	2009	In vitro studies using phorbol 12-myristyl 13-acetate (PMA) stimulated macrophage-like THP-1 (mTHP-1) cells were focused on cytotoxicity of both polymers and particles, and their potential to stimulate IL-8 release via the TLR-2 pathway.	Tetradecanoylphorbol Acetate	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
19694614-5	2009	In vitro studies using phorbol 12-myristyl 13-acetate (PMA) stimulated macrophage-like THP-1 (mTHP-1) cells were focused on cytotoxicity of both polymers and particles, and their potential to stimulate IL-8 release via the TLR-2 pathway.	Tetradecanoylphorbol Acetate	55-58	toll like receptor 2	Homo sapiens	223-228
19639210-6	2009	The inhibitors against NF-kappaB and mitogen-activated protein kinases (MAP kinase) including ERK and JNK pathways suppressed TPA-induced luciferase activity of MMP-1, -3 and -7 promoters.	Tetradecanoylphorbol Acetate	126-129	mitogen-activated protein kinase 8	Homo sapiens	102-105
19541923-12	2009	Ectopic expression of c-Jun/c-Fos or p300 or treatment of cells with phorbol 12-myristate 13-acetate (PMA) stimulated endogenous TFF2 mRNA expression and promoter activity, and p53 inhibited the effects of AP-1 and PMA on TFF2.	Tetradecanoylphorbol Acetate	69-100	trefoil factor 2	Homo sapiens	129-133
19409374-3	2009	In the present study, we assessed the role of iNOS in the skin inflammation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	87-123	nitric oxide synthase 2, inducible	Mus musculus	46-50
19409374-3	2009	In the present study, we assessed the role of iNOS in the skin inflammation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	125-128	nitric oxide synthase 2, inducible	Mus musculus	46-50
19409374-4	2009	Mice deficient in iNOS had reduced edema and cellular infiltration in the skin following topical TPA application.	Tetradecanoylphorbol Acetate	97-100	nitric oxide synthase 2, inducible	Mus musculus	18-22
19409374-5	2009	Moreover, the genetic blockage of iNOS signaling inhibited the TPA-induced ERK and p38 activation resulting in reduced COX-2 upregulation.	Tetradecanoylphorbol Acetate	63-66	nitric oxide synthase 2, inducible	Mus musculus	34-38
19409374-7	2009	Together, these results indicate that TPA induces the activation of several iNOS-dependent intracellular signaling pathways that have a key role in the control of inflammatory response in the skin.	Tetradecanoylphorbol Acetate	38-41	nitric oxide synthase 2, inducible	Mus musculus	76-80
19781328-12	2009	RESULTS: Confocal microscopy showed THP-1 cells differentiated by 100 ng/ml of PMA for five days uptake more AcLDL than differentiated for two days.	Tetradecanoylphorbol Acetate	79-82	GLI family zinc finger 2	Homo sapiens	36-41
19541923-12	2009	Ectopic expression of c-Jun/c-Fos or p300 or treatment of cells with phorbol 12-myristate 13-acetate (PMA) stimulated endogenous TFF2 mRNA expression and promoter activity, and p53 inhibited the effects of AP-1 and PMA on TFF2.	Tetradecanoylphorbol Acetate	69-100	tumor protein p53	Homo sapiens	177-180
19541923-12	2009	Ectopic expression of c-Jun/c-Fos or p300 or treatment of cells with phorbol 12-myristate 13-acetate (PMA) stimulated endogenous TFF2 mRNA expression and promoter activity, and p53 inhibited the effects of AP-1 and PMA on TFF2.	Tetradecanoylphorbol Acetate	69-100	trefoil factor 2	Homo sapiens	222-226
19541923-12	2009	Ectopic expression of c-Jun/c-Fos or p300 or treatment of cells with phorbol 12-myristate 13-acetate (PMA) stimulated endogenous TFF2 mRNA expression and promoter activity, and p53 inhibited the effects of AP-1 and PMA on TFF2.	Tetradecanoylphorbol Acetate	102-105	trefoil factor 2	Homo sapiens	129-133
19541923-12	2009	Ectopic expression of c-Jun/c-Fos or p300 or treatment of cells with phorbol 12-myristate 13-acetate (PMA) stimulated endogenous TFF2 mRNA expression and promoter activity, and p53 inhibited the effects of AP-1 and PMA on TFF2.	Tetradecanoylphorbol Acetate	102-105	tumor protein p53	Homo sapiens	177-180
19541923-12	2009	Ectopic expression of c-Jun/c-Fos or p300 or treatment of cells with phorbol 12-myristate 13-acetate (PMA) stimulated endogenous TFF2 mRNA expression and promoter activity, and p53 inhibited the effects of AP-1 and PMA on TFF2.	Tetradecanoylphorbol Acetate	102-105	trefoil factor 2	Homo sapiens	222-226
19698232-3	2009	The results showed that PKC activity reached the maximal level at 30 minutes after treatment with phorbol-myristate-acetate (PMA), and the peak of CD44 phosphorylation and CD44 expression appeared at the same time, which all increased significantly as compared with control group (p &lt; 0.001).	Tetradecanoylphorbol Acetate	98-123	proline rich transmembrane protein 2	Homo sapiens	24-27
19723105-0	2009	Effects of cotreatment of 12-O-tetradecanoylphorbol-13-acetate and H2O2 on apoptotic regulation via AMP-activated protein kinase-cyclooxygenase-2 signals.	Tetradecanoylphorbol Acetate	26-62	prostaglandin-endoperoxide synthase 2	Homo sapiens	129-145
19723105-4	2009	In HT-29 colon cancer cells, the regulation of COX-2 expression by treating with TPA (12-O-tetradecanoylphorbol-13-acetate), low-level H(2)O(2), high-level H(2)O(2), and finally the combinations of TPA and low H(2)O(2) or high H(2)O(2) was investigated.	Tetradecanoylphorbol Acetate	81-84	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52
19723105-4	2009	In HT-29 colon cancer cells, the regulation of COX-2 expression by treating with TPA (12-O-tetradecanoylphorbol-13-acetate), low-level H(2)O(2), high-level H(2)O(2), and finally the combinations of TPA and low H(2)O(2) or high H(2)O(2) was investigated.	Tetradecanoylphorbol Acetate	86-122	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52
19723105-4	2009	In HT-29 colon cancer cells, the regulation of COX-2 expression by treating with TPA (12-O-tetradecanoylphorbol-13-acetate), low-level H(2)O(2), high-level H(2)O(2), and finally the combinations of TPA and low H(2)O(2) or high H(2)O(2) was investigated.	Tetradecanoylphorbol Acetate	198-201	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52
19723105-5	2009	We found that COX-2 expression levels with treatment reacted as follows: with TPA alone &gt; TPA and low H(2)O(2) &gt; low H(2)O(2) &gt; high H(2)O(2) &gt; TPA and high H(2)O(2).	Tetradecanoylphorbol Acetate	78-81	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19
19723105-5	2009	We found that COX-2 expression levels with treatment reacted as follows: with TPA alone &gt; TPA and low H(2)O(2) &gt; low H(2)O(2) &gt; high H(2)O(2) &gt; TPA and high H(2)O(2).	Tetradecanoylphorbol Acetate	93-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19
19723105-5	2009	We found that COX-2 expression levels with treatment reacted as follows: with TPA alone &gt; TPA and low H(2)O(2) &gt; low H(2)O(2) &gt; high H(2)O(2) &gt; TPA and high H(2)O(2).	Tetradecanoylphorbol Acetate	93-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19
19723105-8	2009	The present findings suggest that both COX-2 stimulators (TPA and H(2)O(2)) might have differential effects on COX-2 and AMPK regulation and further apoptotic regulation.	Tetradecanoylphorbol Acetate	58-61	prostaglandin-endoperoxide synthase 2	Homo sapiens	39-44
19723105-8	2009	The present findings suggest that both COX-2 stimulators (TPA and H(2)O(2)) might have differential effects on COX-2 and AMPK regulation and further apoptotic regulation.	Tetradecanoylphorbol Acetate	58-61	prostaglandin-endoperoxide synthase 2	Homo sapiens	111-116
19429793-0	2009	Phorbol 12-myristate 13-acetate potentiation of N-methyl-D-aspartate-induced currents in primary cultured cerebellar granule cells is mediated by protein kinase C alpha.	Tetradecanoylphorbol Acetate	0-31	protein kinase C alpha	Homo sapiens	146-168
19429793-1	2009	We have previously reported that activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) results in potentiation of N-methyl-D-aspartate-induced currents (I(NMDA))of receptors contained in primary cultured cerebellar granule cells (CGCs).	Tetradecanoylphorbol Acetate	73-104	protein kinase C alpha	Homo sapiens	65-68
19429793-1	2009	We have previously reported that activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) results in potentiation of N-methyl-D-aspartate-induced currents (I(NMDA))of receptors contained in primary cultured cerebellar granule cells (CGCs).	Tetradecanoylphorbol Acetate	106-109	protein kinase C alpha	Homo sapiens	65-68
19429793-10	2009	Collectively, our data provide strong evidence that PMA-enhanced function of native NMDA receptors expressed in primary cultured CGCs is mediated by activation of PKCalpha.	Tetradecanoylphorbol Acetate	52-55	protein kinase C alpha	Homo sapiens	163-171
19698232-3	2009	The results showed that PKC activity reached the maximal level at 30 minutes after treatment with phorbol-myristate-acetate (PMA), and the peak of CD44 phosphorylation and CD44 expression appeared at the same time, which all increased significantly as compared with control group (p &lt; 0.001).	Tetradecanoylphorbol Acetate	125-128	proline rich transmembrane protein 2	Homo sapiens	24-27
19420001-4	2009	The growth factors IGF-I and acidic FGF induced the highest increase in PTPalpha phosphorylation at tyrosine 789, followed by PMA and lysophosphatidic acid, while EGF had little effect.	Tetradecanoylphorbol Acetate	126-129	insulin like growth factor 1	Homo sapiens	19-24
19414503-6	2009	Furthermore, 13-HOA (8-40 muM) suppressed TPA-induced anchorage-independent growth of JB6 mouse epidermal cells by 70-100%, whereas LA was virtually inactive.	Tetradecanoylphorbol Acetate	42-45	latexin	Homo sapiens	26-29
19420016-5	2009	Using specific inhibitors, we confirmed that PMA-induced cell invasion and MMP-9 expression is primarily regulated by nuclear factor-kappa B (NF-kappaB) activation via phosphatidylinositol 3-kinase (PI3K)/Akt and activator protein-1 (AP-1) activation via extracellular signal-regulated kinase (ERK)1/2.	Tetradecanoylphorbol Acetate	45-48	AKT serine/threonine kinase 1	Homo sapiens	205-208
19420016-5	2009	Using specific inhibitors, we confirmed that PMA-induced cell invasion and MMP-9 expression is primarily regulated by nuclear factor-kappa B (NF-kappaB) activation via phosphatidylinositol 3-kinase (PI3K)/Akt and activator protein-1 (AP-1) activation via extracellular signal-regulated kinase (ERK)1/2.	Tetradecanoylphorbol Acetate	45-48	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	213-232
19420016-5	2009	Using specific inhibitors, we confirmed that PMA-induced cell invasion and MMP-9 expression is primarily regulated by nuclear factor-kappa B (NF-kappaB) activation via phosphatidylinositol 3-kinase (PI3K)/Akt and activator protein-1 (AP-1) activation via extracellular signal-regulated kinase (ERK)1/2.	Tetradecanoylphorbol Acetate	45-48	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	234-238
19420016-5	2009	Using specific inhibitors, we confirmed that PMA-induced cell invasion and MMP-9 expression is primarily regulated by nuclear factor-kappa B (NF-kappaB) activation via phosphatidylinositol 3-kinase (PI3K)/Akt and activator protein-1 (AP-1) activation via extracellular signal-regulated kinase (ERK)1/2.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase 1	Homo sapiens	255-301
19420016-6	2009	KPS-A decreased PMA-induced transcriptional activation of NF-kappaB and AP-1 and inhibited PMA-induced phosphorylation of ERK1/2 and Akt.	Tetradecanoylphorbol Acetate	16-19	nuclear factor kappa B subunit 1	Homo sapiens	58-67
19420016-6	2009	KPS-A decreased PMA-induced transcriptional activation of NF-kappaB and AP-1 and inhibited PMA-induced phosphorylation of ERK1/2 and Akt.	Tetradecanoylphorbol Acetate	16-19	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-76
19420016-6	2009	KPS-A decreased PMA-induced transcriptional activation of NF-kappaB and AP-1 and inhibited PMA-induced phosphorylation of ERK1/2 and Akt.	Tetradecanoylphorbol Acetate	91-94	mitogen-activated protein kinase 3	Homo sapiens	122-128
19509226-9	2009	Adiponectin treatment significantly decreased forskolin/PMA-stimulated aromatase expression, consistent with the decreased nuclear translocation of CRTC2 and the decreased binding of CRTC2 to PII.	Tetradecanoylphorbol Acetate	56-59	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
19447859-5	2009	In addition, pterostilbene can inhibit TPA-induced expression of vascular endothelial growth factor, epidermal growth factor and epidermal growth factor receptor.	Tetradecanoylphorbol Acetate	39-42	vascular endothelial growth factor A	Homo sapiens	65-99
19447859-5	2009	In addition, pterostilbene can inhibit TPA-induced expression of vascular endothelial growth factor, epidermal growth factor and epidermal growth factor receptor.	Tetradecanoylphorbol Acetate	39-42	epidermal growth factor receptor	Homo sapiens	129-161
19447859-6	2009	Transient transfection experiments also showed that pterostilbene strongly inhibited TPA-stimulated nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1)-dependent transcriptional activity in HepG(2) cells.	Tetradecanoylphorbol Acetate	85-88	nuclear factor kappa B subunit 1	Homo sapiens	100-122
19447859-6	2009	Transient transfection experiments also showed that pterostilbene strongly inhibited TPA-stimulated nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1)-dependent transcriptional activity in HepG(2) cells.	Tetradecanoylphorbol Acetate	85-88	nuclear factor kappa B subunit 1	Homo sapiens	124-133
19447859-6	2009	Transient transfection experiments also showed that pterostilbene strongly inhibited TPA-stimulated nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1)-dependent transcriptional activity in HepG(2) cells.	Tetradecanoylphorbol Acetate	85-88	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	139-158
19447859-6	2009	Transient transfection experiments also showed that pterostilbene strongly inhibited TPA-stimulated nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1)-dependent transcriptional activity in HepG(2) cells.	Tetradecanoylphorbol Acetate	85-88	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	160-164
19447859-7	2009	Moreover, pterostilbene can suppress TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, c-Jun N-terminal kinases 1/2 and phosphatidylinositol 3-kinase/Akt and protein kinase C that are upstream of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 3	Homo sapiens	63-104
19447859-7	2009	Moreover, pterostilbene can suppress TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, c-Jun N-terminal kinases 1/2 and phosphatidylinositol 3-kinase/Akt and protein kinase C that are upstream of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 14	Homo sapiens	106-109
19447859-7	2009	Moreover, pterostilbene can suppress TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, c-Jun N-terminal kinases 1/2 and phosphatidylinositol 3-kinase/Akt and protein kinase C that are upstream of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	37-40	AKT serine/threonine kinase 1	Homo sapiens	207-210
19447859-7	2009	Moreover, pterostilbene can suppress TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, c-Jun N-terminal kinases 1/2 and phosphatidylinositol 3-kinase/Akt and protein kinase C that are upstream of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	37-40	nuclear factor kappa B subunit 1	Homo sapiens	253-262
19447859-7	2009	Moreover, pterostilbene can suppress TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, c-Jun N-terminal kinases 1/2 and phosphatidylinositol 3-kinase/Akt and protein kinase C that are upstream of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	37-40	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	267-271
19332055-5	2009	Here we have shown MAFB to be highly induced in human hematopoietic cells undergoing macrophage differentiation following Tfe3 ectopic expression, and to be down regulated, compared to the controls, in the same cell population following Phorbol Esters (PMA) dependent differentiation coupled to Tfe3 gene silencing.	Tetradecanoylphorbol Acetate	253-256	MAF bZIP transcription factor B	Homo sapiens	19-23
19376210-3	2009	Treatment of K562 chronic myelogenous leukemia cells with phorbol-12-myristate-13-acetate (PMA) induces megakaryocytic differentiation and Rac2 gene transcription following a lag of 6-12 h. Promoter/luciferase reporter gene assays reveal that a 135 bp cis-element located between -4223 and -4008 bp upstream of the Rac2 transcription start site is necessary and sufficient for PMA-induced gene expression.	Tetradecanoylphorbol Acetate	58-89	Rac family small GTPase 2	Homo sapiens	139-143
19376210-3	2009	Treatment of K562 chronic myelogenous leukemia cells with phorbol-12-myristate-13-acetate (PMA) induces megakaryocytic differentiation and Rac2 gene transcription following a lag of 6-12 h. Promoter/luciferase reporter gene assays reveal that a 135 bp cis-element located between -4223 and -4008 bp upstream of the Rac2 transcription start site is necessary and sufficient for PMA-induced gene expression.	Tetradecanoylphorbol Acetate	58-89	Rac family small GTPase 2	Homo sapiens	315-319
19376210-3	2009	Treatment of K562 chronic myelogenous leukemia cells with phorbol-12-myristate-13-acetate (PMA) induces megakaryocytic differentiation and Rac2 gene transcription following a lag of 6-12 h. Promoter/luciferase reporter gene assays reveal that a 135 bp cis-element located between -4223 and -4008 bp upstream of the Rac2 transcription start site is necessary and sufficient for PMA-induced gene expression.	Tetradecanoylphorbol Acetate	91-94	Rac family small GTPase 2	Homo sapiens	139-143
19376210-3	2009	Treatment of K562 chronic myelogenous leukemia cells with phorbol-12-myristate-13-acetate (PMA) induces megakaryocytic differentiation and Rac2 gene transcription following a lag of 6-12 h. Promoter/luciferase reporter gene assays reveal that a 135 bp cis-element located between -4223 and -4008 bp upstream of the Rac2 transcription start site is necessary and sufficient for PMA-induced gene expression.	Tetradecanoylphorbol Acetate	91-94	Rac family small GTPase 2	Homo sapiens	315-319
19420016-6	2009	KPS-A decreased PMA-induced transcriptional activation of NF-kappaB and AP-1 and inhibited PMA-induced phosphorylation of ERK1/2 and Akt.	Tetradecanoylphorbol Acetate	91-94	AKT serine/threonine kinase 1	Homo sapiens	133-136
19420016-9	2009	These results suggest that KPS-A inhibits PMA-induced invasion by reducing MMP-9 activation, mainly via the PI3K/Akt/NF-kappaB and PKCdelta/ERK/AP-1 pathways in MCF-7 cells and blocks tumor growth and MMP-9-mediated invasiveness in mice with breast carcinoma.	Tetradecanoylphorbol Acetate	42-45	AKT serine/threonine kinase 1	Homo sapiens	113-116
19420016-9	2009	These results suggest that KPS-A inhibits PMA-induced invasion by reducing MMP-9 activation, mainly via the PI3K/Akt/NF-kappaB and PKCdelta/ERK/AP-1 pathways in MCF-7 cells and blocks tumor growth and MMP-9-mediated invasiveness in mice with breast carcinoma.	Tetradecanoylphorbol Acetate	42-45	nuclear factor kappa B subunit 1	Homo sapiens	117-126
19420016-9	2009	These results suggest that KPS-A inhibits PMA-induced invasion by reducing MMP-9 activation, mainly via the PI3K/Akt/NF-kappaB and PKCdelta/ERK/AP-1 pathways in MCF-7 cells and blocks tumor growth and MMP-9-mediated invasiveness in mice with breast carcinoma.	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 1	Homo sapiens	140-143
19420016-9	2009	These results suggest that KPS-A inhibits PMA-induced invasion by reducing MMP-9 activation, mainly via the PI3K/Akt/NF-kappaB and PKCdelta/ERK/AP-1 pathways in MCF-7 cells and blocks tumor growth and MMP-9-mediated invasiveness in mice with breast carcinoma.	Tetradecanoylphorbol Acetate	42-45	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	144-148
19414503-7	2009	13-HOA (40 muM) inhibited TPA-induced activator protein-1 transactivation but not extracellular signal-regulated kinase1/2 activation.	Tetradecanoylphorbol Acetate	26-29	latexin	Homo sapiens	11-14
19420016-0	2009	Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	28-31	AKT serine/threonine kinase 1	Homo sapiens	97-100
19420016-4	2009	PMA-induced cell invasion was blocked in the presence of a primary antibody of MMP-9, and KPS-A suppressed the increased expression and/or secretion of MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1.	Tetradecanoylphorbol Acetate	0-3	TIMP metallopeptidase inhibitor 1	Homo sapiens	162-208
19420016-5	2009	Using specific inhibitors, we confirmed that PMA-induced cell invasion and MMP-9 expression is primarily regulated by nuclear factor-kappa B (NF-kappaB) activation via phosphatidylinositol 3-kinase (PI3K)/Akt and activator protein-1 (AP-1) activation via extracellular signal-regulated kinase (ERK)1/2.	Tetradecanoylphorbol Acetate	45-48	nuclear factor kappa B subunit 1	Homo sapiens	118-140
19420016-5	2009	Using specific inhibitors, we confirmed that PMA-induced cell invasion and MMP-9 expression is primarily regulated by nuclear factor-kappa B (NF-kappaB) activation via phosphatidylinositol 3-kinase (PI3K)/Akt and activator protein-1 (AP-1) activation via extracellular signal-regulated kinase (ERK)1/2.	Tetradecanoylphorbol Acetate	45-48	nuclear factor kappa B subunit 1	Homo sapiens	142-151
19366707-4	2009	Within 1 h following TPA treatment of skin epithelial (JB6) cells, p53 accumulated in mitochondria.	Tetradecanoylphorbol Acetate	21-24	tumor protein p53	Homo sapiens	67-70
19609061-4	2009	The application of TPA increased the PiCl-induced infiltration of eosinophils and mast cells at the inflammatory site and shifted the cytokine milieu from Th1 to Th2.	Tetradecanoylphorbol Acetate	19-22	negative elongation factor complex member C/D, Th1l	Mus musculus	155-158
19379723-7	2009	As immunostaining analysis revealed that PDE7A is expressed in the epidermis and TNF-alpha is known to contribute to the TPA-induced edema, it is possible that the inhibitory effect of ASB16165 on skin edema in mouse TPA-induced dermatitis model is mediated by suppression of TNF-alpha production.	Tetradecanoylphorbol Acetate	121-124	tumor necrosis factor	Mus musculus	81-90
19420081-8	2009	After stimulation with phorbol myristate acetate-ionomycin, high gamma interferon and low IL-4 levels were detected.	Tetradecanoylphorbol Acetate	23-48	interleukin 4	Homo sapiens	90-94
19379723-3	2009	The TPA challenge also increased the level of TNF-alpha at the application site, and the ASB16165 treatment reduced the TNF-alpha level in the skin.	Tetradecanoylphorbol Acetate	4-7	tumor necrosis factor	Mus musculus	46-55
19379723-4	2009	In addition, ASB16165 suppressed the production of TNF-alpha by human keratinocytes stimulated in vitro with TPA and calcium ionophore.	Tetradecanoylphorbol Acetate	109-112	tumor necrosis factor	Homo sapiens	51-60
19366707-6	2009	The suppressive effect of NPM on p53 mitochondrial localization is also observed in TPA-treated primary epithelial cells and in JB6 cells treated with doxorubicin.	Tetradecanoylphorbol Acetate	84-87	tumor protein p53	Homo sapiens	33-36
19205902-0	2009	Copper egress is induced by PMA in human THP-1 monocytic cell line.	Tetradecanoylphorbol Acetate	28-31	GLI family zinc finger 2	Homo sapiens	41-46
19205902-3	2009	In current manuscript, using THP-1 cells, a human monocytic cell line, we found that ATP7A expression was increased in cells exposed to phorbol-12-myristate-13-acetate (PMA), a potent inducer of neovascularization and cancer.	Tetradecanoylphorbol Acetate	136-167	GLI family zinc finger 2	Homo sapiens	29-34
19205902-3	2009	In current manuscript, using THP-1 cells, a human monocytic cell line, we found that ATP7A expression was increased in cells exposed to phorbol-12-myristate-13-acetate (PMA), a potent inducer of neovascularization and cancer.	Tetradecanoylphorbol Acetate	169-172	GLI family zinc finger 2	Homo sapiens	29-34
19205902-6	2009	PMA treatment in THP-1 cells resulted in increased expression of matrix metalloproteinase (MMP) 9 and vascular endothelial growth factor receptor 1 (VEGFR1), whereas inhibition of ATP7A resulted in suppression of PMA-induced expression of VEGFR1, but not MMP9.	Tetradecanoylphorbol Acetate	0-3	GLI family zinc finger 2	Homo sapiens	17-22
19205902-6	2009	PMA treatment in THP-1 cells resulted in increased expression of matrix metalloproteinase (MMP) 9 and vascular endothelial growth factor receptor 1 (VEGFR1), whereas inhibition of ATP7A resulted in suppression of PMA-induced expression of VEGFR1, but not MMP9.	Tetradecanoylphorbol Acetate	0-3	fms related receptor tyrosine kinase 1	Homo sapiens	102-147
19205902-6	2009	PMA treatment in THP-1 cells resulted in increased expression of matrix metalloproteinase (MMP) 9 and vascular endothelial growth factor receptor 1 (VEGFR1), whereas inhibition of ATP7A resulted in suppression of PMA-induced expression of VEGFR1, but not MMP9.	Tetradecanoylphorbol Acetate	0-3	fms related receptor tyrosine kinase 1	Homo sapiens	149-155
19205902-6	2009	PMA treatment in THP-1 cells resulted in increased expression of matrix metalloproteinase (MMP) 9 and vascular endothelial growth factor receptor 1 (VEGFR1), whereas inhibition of ATP7A resulted in suppression of PMA-induced expression of VEGFR1, but not MMP9.	Tetradecanoylphorbol Acetate	0-3	fms related receptor tyrosine kinase 1	Homo sapiens	239-245
19205902-8	2009	Collectively, we demonstrate that PMA induces copper egress in THP-1 cells, which is regulated by ATP7A, and ATP7A regulates VEGFR1 expression.	Tetradecanoylphorbol Acetate	34-37	GLI family zinc finger 2	Homo sapiens	63-68
19279008-1	2009	Activation of protein kinase C (PKC) by the phorbol ester (phorbol 12-myristate 13-acetate) induces ceramide formation through the salvage pathway involving, in part, acid beta-glucosidase 1 (GBA1), which cleaves glucosylceramide to ceramide.	Tetradecanoylphorbol Acetate	59-90	proline rich transmembrane protein 2	Homo sapiens	14-30
19472186-3	2009	Treatment with both TPA and TNFalpha decreased mRNA levels of PPARgamma, aP2, LPL and adiponectin.	Tetradecanoylphorbol Acetate	20-23	peroxisome proliferator activated receptor gamma	Homo sapiens	62-71
19472186-3	2009	Treatment with both TPA and TNFalpha decreased mRNA levels of PPARgamma, aP2, LPL and adiponectin.	Tetradecanoylphorbol Acetate	20-23	adiponectin, C1Q and collagen domain containing	Homo sapiens	86-97
19181503-0	2009	Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase kinase 7	Homo sapiens	94-97
19181503-0	2009	Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase 1	Homo sapiens	98-101
19181503-2	2009	Herein, we investigated the effect of silibinin, a major constituent (flavanolignan) of the fruits of Silybum marianum, on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 and VEGF expression in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	123-160	vascular endothelial growth factor A	Homo sapiens	185-189
19181503-3	2009	The expression of MMP-9 and VEGF in response to TPA was increased, whereas TPA-induced MMP-9 and VEGF expression was decreased by silibinin.	Tetradecanoylphorbol Acetate	48-51	vascular endothelial growth factor A	Homo sapiens	28-32
19181503-3	2009	The expression of MMP-9 and VEGF in response to TPA was increased, whereas TPA-induced MMP-9 and VEGF expression was decreased by silibinin.	Tetradecanoylphorbol Acetate	75-78	vascular endothelial growth factor A	Homo sapiens	97-101
19288401-8	2009	The compounds also suppressed fMLP- and AA-induced tyrosyl or PMA-induced serine/threonine phosphorylation, and translocation of cytosolic compounds, p47 (phox), p67 (phox) and Rac to the cell membrane in parallel with the suppression of the stimulus-induced superoxide generation.	Tetradecanoylphorbol Acetate	62-65	formyl peptide receptor 1	Homo sapiens	30-34
19288401-8	2009	The compounds also suppressed fMLP- and AA-induced tyrosyl or PMA-induced serine/threonine phosphorylation, and translocation of cytosolic compounds, p47 (phox), p67 (phox) and Rac to the cell membrane in parallel with the suppression of the stimulus-induced superoxide generation.	Tetradecanoylphorbol Acetate	62-65	AKT serine/threonine kinase 1	Homo sapiens	177-180
19372735-5	2009	We quantitatively compared the efficacy of various proteasome inhibitors (MG132, lactacystin and epoxomicin) and IKK inhibitors (BAY 11-7082 and PS1145) to block NFkappaB activity induced by TNFalpha or TPA and to sensitize LNCaP prostate carcinoma cells to apoptosis.	Tetradecanoylphorbol Acetate	203-206	nuclear factor kappa B subunit 1	Homo sapiens	162-170
19372735-8	2009	Furthermore, in contrast to IKK inhibitors, all studied proteasome inhibitors specifically blocked TPA-induced generation de novo of NFkappaB p50 homodimers--(p50/p50).	Tetradecanoylphorbol Acetate	99-102	nuclear factor kappa B subunit 1	Homo sapiens	133-141
19372735-8	2009	Furthermore, in contrast to IKK inhibitors, all studied proteasome inhibitors specifically blocked TPA-induced generation de novo of NFkappaB p50 homodimers--(p50/p50).	Tetradecanoylphorbol Acetate	99-102	nuclear factor kappa B subunit 1	Homo sapiens	142-145
19372735-8	2009	Furthermore, in contrast to IKK inhibitors, all studied proteasome inhibitors specifically blocked TPA-induced generation de novo of NFkappaB p50 homodimers--(p50/p50).	Tetradecanoylphorbol Acetate	99-102	nuclear factor kappa B subunit 1	Homo sapiens	159-162
19372735-8	2009	Furthermore, in contrast to IKK inhibitors, all studied proteasome inhibitors specifically blocked TPA-induced generation de novo of NFkappaB p50 homodimers--(p50/p50).	Tetradecanoylphorbol Acetate	99-102	nuclear factor kappa B subunit 1	Homo sapiens	159-162
19372735-9	2009	These results suggest that the proteasome plays a dominant role in TPA-induced formation of functional p50 homodimers, while IKK activity is less important for this process.	Tetradecanoylphorbol Acetate	67-70	nuclear factor kappa B subunit 1	Homo sapiens	103-106
19432991-8	2009	The counter-regulated genes have been clustered into functional categories and bioinformatic analysis has identified the B-Raf/Mek/Erk branch of the MAP kinase pathway as one containing several genes whose upregulation by TPA is blocked by ATRA.	Tetradecanoylphorbol Acetate	222-225	mitogen-activated protein kinase 1	Mus musculus	131-134
19514997-8	2009	Furthermore, LEJL decreased the production of tumor necrosis factor-alpha in phorbol 12-myristate 13-acetate and A23187-stimulated human mast cells.	Tetradecanoylphorbol Acetate	77-108	tumor necrosis factor	Homo sapiens	46-73
19327373-5	2009	Inhibition of classical and novel PKC isoforms by treatment with bisindolylmaleimide or PKC down-regulation by long-term treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) could not prevent apoptosis induced by palmitate or stearate.	Tetradecanoylphorbol Acetate	136-173	proline rich transmembrane protein 2	Homo sapiens	88-91
19327373-5	2009	Inhibition of classical and novel PKC isoforms by treatment with bisindolylmaleimide or PKC down-regulation by long-term treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) could not prevent apoptosis induced by palmitate or stearate.	Tetradecanoylphorbol Acetate	175-178	proline rich transmembrane protein 2	Homo sapiens	34-37
19181503-4	2009	To investigate the regulatory mechanism of silibinin on TPA-induced MMP-9 and VEGF expression, we pretreated cells with various inhibitors, such as UO126 (MEK1/2 inhibitor), SP600125 (JNK inhibitor), and SB203580 (p38 inhibitor).	Tetradecanoylphorbol Acetate	56-59	vascular endothelial growth factor A	Homo sapiens	78-82
19181503-7	2009	TPA-induced MEK and ERK phosphorylation was significantly decreased by silibinin in MCF7 cells.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 7	Homo sapiens	12-15
19181503-7	2009	TPA-induced MEK and ERK phosphorylation was significantly decreased by silibinin in MCF7 cells.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	20-23
19181503-8	2009	TPA-induced VEGF expression was also suppressed by UO126.	Tetradecanoylphorbol Acetate	0-3	vascular endothelial growth factor A	Homo sapiens	12-16
19181503-10	2009	Taken together, we suggest that the inhibition of TPA-induced MMP-9 and VEGF expression by silibinin is mediated by the suppression of the Raf/MEK/ERK pathway in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	50-53	vascular endothelial growth factor A	Homo sapiens	72-76
19181503-10	2009	Taken together, we suggest that the inhibition of TPA-induced MMP-9 and VEGF expression by silibinin is mediated by the suppression of the Raf/MEK/ERK pathway in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	50-53	mitogen-activated protein kinase kinase 7	Homo sapiens	143-146
19181503-10	2009	Taken together, we suggest that the inhibition of TPA-induced MMP-9 and VEGF expression by silibinin is mediated by the suppression of the Raf/MEK/ERK pathway in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	50-53	mitogen-activated protein kinase 1	Homo sapiens	147-150
19375915-5	2009	Apparently, phorbol myristate acetate (PMA) stimulated expressions of ERK, JNK and p38 were altered in the presence of potent tumour inducer, phorbol myristate acetate QAGlc, suggesting their suppression also contributes to QAGlc-mediated inhibition of MMP-9 and MMP-2.	Tetradecanoylphorbol Acetate	12-37	mitogen-activated protein kinase 14	Homo sapiens	83-86
19375915-5	2009	Apparently, phorbol myristate acetate (PMA) stimulated expressions of ERK, JNK and p38 were altered in the presence of potent tumour inducer, phorbol myristate acetate QAGlc, suggesting their suppression also contributes to QAGlc-mediated inhibition of MMP-9 and MMP-2.	Tetradecanoylphorbol Acetate	39-42	mitogen-activated protein kinase 14	Homo sapiens	83-86
19375915-5	2009	Apparently, phorbol myristate acetate (PMA) stimulated expressions of ERK, JNK and p38 were altered in the presence of potent tumour inducer, phorbol myristate acetate QAGlc, suggesting their suppression also contributes to QAGlc-mediated inhibition of MMP-9 and MMP-2.	Tetradecanoylphorbol Acetate	142-167	mitogen-activated protein kinase 14	Homo sapiens	83-86
19301261-5	2009	The inhibitory effect of Ssd on PMA-induced T cell activation was associated with down-regulation of NF-kappaB signaling through suppression of IKK and Akt activities.	Tetradecanoylphorbol Acetate	32-35	thymoma viral proto-oncogene 1	Mus musculus	152-155
19279008-5	2009	Knockdown of GBA1 also evoked the hyperproduction of IL-6 in response to 4beta phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	73-110	interleukin 6	Homo sapiens	53-57
19279008-1	2009	Activation of protein kinase C (PKC) by the phorbol ester (phorbol 12-myristate 13-acetate) induces ceramide formation through the salvage pathway involving, in part, acid beta-glucosidase 1 (GBA1), which cleaves glucosylceramide to ceramide.	Tetradecanoylphorbol Acetate	59-90	proline rich transmembrane protein 2	Homo sapiens	32-35
19279008-3	2009	Inhibition of ceramide formation by fumonisin B1 or down-regulation of PKCdelta potentiated PMA-induced activation of p38 in human breast cancer MCF-7 cells.	Tetradecanoylphorbol Acetate	92-95	mitogen-activated protein kinase 14	Homo sapiens	118-121
19333010-6	2009	The increase in KLF6 by PMA was associated with upregulation of the cyclin-dependent kinase inhibitors (CDKIs) p21(WAF1/CIP1) and p27(KIP1).	Tetradecanoylphorbol Acetate	24-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	111-114
19333010-6	2009	The increase in KLF6 by PMA was associated with upregulation of the cyclin-dependent kinase inhibitors (CDKIs) p21(WAF1/CIP1) and p27(KIP1).	Tetradecanoylphorbol Acetate	24-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	115-119
19333010-6	2009	The increase in KLF6 by PMA was associated with upregulation of the cyclin-dependent kinase inhibitors (CDKIs) p21(WAF1/CIP1) and p27(KIP1).	Tetradecanoylphorbol Acetate	24-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	120-124
19340542-9	2009	Treatment with the ERK1/2 inhibitor, PD98059 (10 microM), or the p38 MAPK-specific inhibitor, SB203580 (10 microM), greatly inhibited the E2-induced ER increase, while the protein kinase C (PKC) activator TPA (1 microM) enhanced it.	Tetradecanoylphorbol Acetate	205-208	mitogen-activated protein kinase 1	Mus musculus	69-73
19168130-7	2009	Treatment with doxycycline/TPA or TPA alone increased phosphorylations of Elk-1(S383), PDK1(S241), Rb(S807/S811), PKCdelta(T505), p38MAPK(T180/Y182), MEK1/2(S217/S221) and ERK2(T185/T187).	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Homo sapiens	172-176
19168130-7	2009	Treatment with doxycycline/TPA or TPA alone increased phosphorylations of Elk-1(S383), PDK1(S241), Rb(S807/S811), PKCdelta(T505), p38MAPK(T180/Y182), MEK1/2(S217/S221) and ERK2(T185/T187).	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 1	Homo sapiens	172-176
19328241-7	2009	Nuclear localized GFP-HDAC5 undergoes quantitative nuclear export (approximately 20-30% within 2 h) in response to hypertrophic agonists such as endothelin-1 (ET-1) and prostaglandin-F2alpha (PGF2alpha), as well as the direct protein kinase C (PKC) activator and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	263-288	histone deacetylase 5	Rattus norvegicus	22-27
19328241-7	2009	Nuclear localized GFP-HDAC5 undergoes quantitative nuclear export (approximately 20-30% within 2 h) in response to hypertrophic agonists such as endothelin-1 (ET-1) and prostaglandin-F2alpha (PGF2alpha), as well as the direct protein kinase C (PKC) activator and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	263-288	endothelin 1	Rattus norvegicus	145-157
19328241-7	2009	Nuclear localized GFP-HDAC5 undergoes quantitative nuclear export (approximately 20-30% within 2 h) in response to hypertrophic agonists such as endothelin-1 (ET-1) and prostaglandin-F2alpha (PGF2alpha), as well as the direct protein kinase C (PKC) activator and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	290-293	histone deacetylase 5	Rattus norvegicus	22-27
19328241-7	2009	Nuclear localized GFP-HDAC5 undergoes quantitative nuclear export (approximately 20-30% within 2 h) in response to hypertrophic agonists such as endothelin-1 (ET-1) and prostaglandin-F2alpha (PGF2alpha), as well as the direct protein kinase C (PKC) activator and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	290-293	endothelin 1	Rattus norvegicus	145-157
19604443-7	2009	However, only anti-CD20 infusion significantly (p=0.05) reduced concentration of fibrinogen (p=0.05), D-dimer (p&lt;0.001), as well as tPA levels (p&lt;0.01).	Tetradecanoylphorbol Acetate	135-138	keratin 20	Homo sapiens	19-23
19604443-8	2009	In contrast, in TNF antibody treated patients only tPA levels were significantly decreased following the treatment (p&lt;0.05).	Tetradecanoylphorbol Acetate	51-54	tumor necrosis factor	Homo sapiens	16-19
19285494-2	2009	We previously reported the unusual characteristics of phorbol 12-myristate 13-acetate (PMA)-induced polymorphonuclear leukocyte spreading over immobilized fibrinogen at acidic pH, including extracellular Ca2+ requirement and independence of protein kinase C (PKC) activity.	Tetradecanoylphorbol Acetate	54-85	fibrinogen beta chain	Homo sapiens	155-165
19285494-2	2009	We previously reported the unusual characteristics of phorbol 12-myristate 13-acetate (PMA)-induced polymorphonuclear leukocyte spreading over immobilized fibrinogen at acidic pH, including extracellular Ca2+ requirement and independence of protein kinase C (PKC) activity.	Tetradecanoylphorbol Acetate	87-90	fibrinogen beta chain	Homo sapiens	155-165
19285494-3	2009	In the present study, we found that PMA-induced spreading was strongly inhibited at pH 6.0 by the serine protease inhibitor phenylmethanesulfonylfluoride at pH 6.0 but was only mildly inhibited at pH 7.2 and not inhibited at pH 8.0; furthermore, PMA-stimulated polymorphonuclear leukocytes markedly digested immobilized fibrinogen only at pH 6.0.	Tetradecanoylphorbol Acetate	36-39	fibrinogen beta chain	Homo sapiens	320-330
19285494-5	2009	Pharmacological studies demonstrated the involvement of Src family protein tyrosine kinases, but not PKC, in H2O2-induced spreading over pre-digested fibrinogen surfaces; this was also the case for PMA-induced spreading at pH 6.0 but not at pH 7.2 or 8.0.	Tetradecanoylphorbol Acetate	198-201	fibrinogen beta chain	Homo sapiens	150-160
19379509-0	2009	Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice.	Tetradecanoylphorbol Acetate	54-57	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	14-20
19435810-3	2009	However, following a 7,12-dimethylbenz(a)anthracene (DMBA)/phorbol-12-myristate-13-acetate two-stage skin carcinogenesis experiment, A-CREB-expressing epidermis develop 5-fold fewer papillomas than wild-type controls.	Tetradecanoylphorbol Acetate	59-90	cAMP responsive element binding protein 1	Mus musculus	135-139
19337254-3	2009	Treatment with TPA resulted in BCL6 degradation and cyclin D2 upregulation.	Tetradecanoylphorbol Acetate	15-18	cyclin D2	Homo sapiens	52-61
19416633-6	2009	Resveratrol significantly inhibited the PMA plus A23187-induction of inflammatory cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8.	Tetradecanoylphorbol Acetate	40-43	tumor necrosis factor	Homo sapiens	100-134
19416633-6	2009	Resveratrol significantly inhibited the PMA plus A23187-induction of inflammatory cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8.	Tetradecanoylphorbol Acetate	40-43	interleukin 6	Homo sapiens	136-154
19416633-6	2009	Resveratrol significantly inhibited the PMA plus A23187-induction of inflammatory cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8.	Tetradecanoylphorbol Acetate	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
19404540-7	2009	In a discontinuous clot assay involving clot-bound thrombin, HSACHV3 assisted clot lysis by limiting clot extension in a tPA- and concentration-dependent manner.	Tetradecanoylphorbol Acetate	121-124	coagulation factor II	Mus musculus	51-59
19232538-2	2009	Induction of THP-1 monocyte differentiation by phorbol 12-myristate 13-acetate (PMA) markedly increased SVCT2 mRNA, protein, and function.	Tetradecanoylphorbol Acetate	47-78	GLI family zinc finger 2	Homo sapiens	13-18
19232538-2	2009	Induction of THP-1 monocyte differentiation by phorbol 12-myristate 13-acetate (PMA) markedly increased SVCT2 mRNA, protein, and function.	Tetradecanoylphorbol Acetate	80-83	GLI family zinc finger 2	Homo sapiens	13-18
19352540-8	2009	Smad7 is in turn regulated by different stimuli, including TGF-beta, IFN-gamma, TNF-alpha as well as ultraviolet and TPA, and mediates the crosstalk between TGF-beta and other signaling pathways.	Tetradecanoylphorbol Acetate	117-120	SMAD family member 7	Homo sapiens	0-5
19220020-9	2009	To address PDP1"s contribution to cellular PSDP phosphatase activity, HEK293 cells were established that stably expressed PDP1 siRNA, leading to a 60% decrease in the level of PDP1 RNA, and concomitant decreases in PDP1 protein and PMA-initiated PSDP phosphatase activity.	Tetradecanoylphorbol Acetate	232-235	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	122-126
19220020-9	2009	To address PDP1"s contribution to cellular PSDP phosphatase activity, HEK293 cells were established that stably expressed PDP1 siRNA, leading to a 60% decrease in the level of PDP1 RNA, and concomitant decreases in PDP1 protein and PMA-initiated PSDP phosphatase activity.	Tetradecanoylphorbol Acetate	232-235	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	122-126
19220020-9	2009	To address PDP1"s contribution to cellular PSDP phosphatase activity, HEK293 cells were established that stably expressed PDP1 siRNA, leading to a 60% decrease in the level of PDP1 RNA, and concomitant decreases in PDP1 protein and PMA-initiated PSDP phosphatase activity.	Tetradecanoylphorbol Acetate	232-235	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	122-126
19220020-10	2009	HEK293 cells harboring the PDP1 siRNA construct also displayed a marked decrease in the extent of PMA-initiated conversion of cellular PSDP to PSMP.	Tetradecanoylphorbol Acetate	98-101	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	27-31
19352540-8	2009	Smad7 is in turn regulated by different stimuli, including TGF-beta, IFN-gamma, TNF-alpha as well as ultraviolet and TPA, and mediates the crosstalk between TGF-beta and other signaling pathways.	Tetradecanoylphorbol Acetate	117-120	transforming growth factor beta 1	Homo sapiens	157-165
19337903-2	2009	Human monocytic cell line (THP-1 cell) was primed to differentiation into macrophages by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	89-114	GLI family zinc finger 2	Homo sapiens	27-32
19414336-5	2009	MATERIALS AND METHODS: A highly responsive HepG2/NF-kappaB/luc clone L for 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion inhibited by methotrexate (MTX) was selected by high-throughput bioluminescent imaging (BLI) in vitro.	Tetradecanoylphorbol Acetate	75-111	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-58
19414336-5	2009	MATERIALS AND METHODS: A highly responsive HepG2/NF-kappaB/luc clone L for 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion inhibited by methotrexate (MTX) was selected by high-throughput bioluminescent imaging (BLI) in vitro.	Tetradecanoylphorbol Acetate	113-116	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-58
19414336-7	2009	RESULTS: The luciferase expression by BLI assay reflected that the TPA-induced NF-kappaB activity was suppressed by MTX after 16 h treatment.	Tetradecanoylphorbol Acetate	67-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	79-88
19414336-8	2009	A positive correlation between in vitro and in vivo MTX-suppressed TPA-induced NF-kappaB activity was indicated.	Tetradecanoylphorbol Acetate	67-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	79-88
19157541-7	2009	Activation of CaR initiated a signaling cascade that activated phorbol-12-myristate-13-acetate (PMA)-insensitive protein kinase C (PKC) isoforms.	Tetradecanoylphorbol Acetate	63-94	calcium sensing receptor	Homo sapiens	14-17
19157541-7	2009	Activation of CaR initiated a signaling cascade that activated phorbol-12-myristate-13-acetate (PMA)-insensitive protein kinase C (PKC) isoforms.	Tetradecanoylphorbol Acetate	96-99	calcium sensing receptor	Homo sapiens	14-17
19337903-2	2009	Human monocytic cell line (THP-1 cell) was primed to differentiation into macrophages by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	116-119	GLI family zinc finger 2	Homo sapiens	27-32
19092850-0	2009	Role of catalase in monocytic differentiation of U937 cells by TPA: hydrogen peroxide as a second messenger.	Tetradecanoylphorbol Acetate	63-66	catalase	Homo sapiens	8-16
19220708-3	2009	In this report, we studied the dynamics of PKC/Ras/ERK pathway signaling, during differentiation of SH-SY5Y neuroblastoma cells upon treatment with the PKC agonist, phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	218-221	mitogen-activated protein kinase 1	Homo sapiens	51-54
19220708-4	2009	Surprisingly, we observed that, among other PKC-dependent signaling events, TPA induced a rapid and sustained decrease of neurofibromin immunoreactivity which was not due to proteolysis.	Tetradecanoylphorbol Acetate	76-79	neurofibromin 1	Homo sapiens	122-135
19220708-7	2009	Moreover, it persisted throughout prolonged treatment and TPA-induced differentiation of SH-SY5Y cells, concurrently with sustained activation of ERK1/2.	Tetradecanoylphorbol Acetate	58-61	mitogen-activated protein kinase 3	Homo sapiens	146-152
18843292-9	2009	Human THP-1 cell line cells, after treated with phorbol myristate acetate (PMA), differentiated to macrophages with M2 functional profiles.	Tetradecanoylphorbol Acetate	48-73	GLI family zinc finger 2	Homo sapiens	6-11
18843292-9	2009	Human THP-1 cell line cells, after treated with phorbol myristate acetate (PMA), differentiated to macrophages with M2 functional profiles.	Tetradecanoylphorbol Acetate	75-78	GLI family zinc finger 2	Homo sapiens	6-11
18843292-10	2009	Coculture with PMA-treated THP-1 macrophages induced COX-2-dependent release of matrix metalloproteinase-9 and subsequent increased invasion of BCC cells.	Tetradecanoylphorbol Acetate	15-18	GLI family zinc finger 2	Homo sapiens	27-32
18843292-10	2009	Coculture with PMA-treated THP-1 macrophages induced COX-2-dependent release of matrix metalloproteinase-9 and subsequent increased invasion of BCC cells.	Tetradecanoylphorbol Acetate	15-18	prostaglandin-endoperoxide synthase 2	Homo sapiens	53-58
19092850-7	2009	Treatment of U937 cells with catalase inhibited the enhancement of ROS generation induced by TPA, and blocked the TPA-induced differentiation of U937 cells.	Tetradecanoylphorbol Acetate	93-96	catalase	Homo sapiens	29-37
19092850-7	2009	Treatment of U937 cells with catalase inhibited the enhancement of ROS generation induced by TPA, and blocked the TPA-induced differentiation of U937 cells.	Tetradecanoylphorbol Acetate	114-117	catalase	Homo sapiens	29-37
19092850-9	2009	However, HP100-1 cells, its variant cell line overexpressing catalase, were resistant to TPA-induced differentiation.	Tetradecanoylphorbol Acetate	89-92	catalase	Homo sapiens	61-69
19092850-5	2009	TPA treatment decreased the expression level of catalase, which catalyzes the decomposition of hydrogen peroxide (H(2)O(2)) to H(2)O and O(2).	Tetradecanoylphorbol Acetate	0-3	catalase	Homo sapiens	48-56
19092850-10	2009	Our results suggest that catalase inhibits monocytic differentiation by TPA; the decrease in catalase level and the accumulation of H(2)O(2) are significant events for monocyte/macrophage differentiation by TPA.	Tetradecanoylphorbol Acetate	72-75	catalase	Homo sapiens	25-33
19092850-10	2009	Our results suggest that catalase inhibits monocytic differentiation by TPA; the decrease in catalase level and the accumulation of H(2)O(2) are significant events for monocyte/macrophage differentiation by TPA.	Tetradecanoylphorbol Acetate	207-210	catalase	Homo sapiens	25-33
19351497-4	2009	RESULTS: The expression of ADRP both mRNA and protein were significantly increased when macrophages were further induced into foam cells by ox-LDLs, however, the same results were not observed during phorbol 12-myristate-13-acetate(PMA)-induced monocyte differentiation into macrophages.	Tetradecanoylphorbol Acetate	200-231	perilipin 2	Homo sapiens	27-31
19092850-10	2009	Our results suggest that catalase inhibits monocytic differentiation by TPA; the decrease in catalase level and the accumulation of H(2)O(2) are significant events for monocyte/macrophage differentiation by TPA.	Tetradecanoylphorbol Acetate	207-210	catalase	Homo sapiens	93-101
19351497-4	2009	RESULTS: The expression of ADRP both mRNA and protein were significantly increased when macrophages were further induced into foam cells by ox-LDLs, however, the same results were not observed during phorbol 12-myristate-13-acetate(PMA)-induced monocyte differentiation into macrophages.	Tetradecanoylphorbol Acetate	232-235	perilipin 2	Homo sapiens	27-31
19144650-8	2009	In contrast, phorbol esters induce Duox2 phosphorylation via protein kinase C activation associated with high H(2)O(2) generation (phorbol 12-myristate 13-acetate EC(50) = 0.8 nm).	Tetradecanoylphorbol Acetate	131-162	dual oxidase 2	Homo sapiens	35-40
18710607-6	2009	The tetradecanoylphorbol acetate plus ionomycin-stimulated IL-2 mRNA level started to increase after ingestion of 400 mg DHA/d, with a maximum after 800 mg intake, and was positively correlated (P &lt; 0.003) with DHA enrichment in cell phospholipids.	Tetradecanoylphorbol Acetate	4-32	interleukin 2	Homo sapiens	59-63
19265538-8	2009	To assess functional consequences, IL-2 production, induced by PMA and ionomycin, was determined using enzyme-linked immunosorbent spot assay (ELISpot).	Tetradecanoylphorbol Acetate	63-66	interleukin 2	Homo sapiens	35-39
19147806-7	2009	Caco-2 BBe cells treated with phorbol 12-myristate 13-acetate, a protein kinase C activator, decreased nuclear HNF-4alpha protein level and binding activity to the human CRBPII gene DR-1-like element, as well as CRBPII gene expression.	Tetradecanoylphorbol Acetate	30-61	hepatocyte nuclear factor 4 alpha	Homo sapiens	111-121
19147806-7	2009	Caco-2 BBe cells treated with phorbol 12-myristate 13-acetate, a protein kinase C activator, decreased nuclear HNF-4alpha protein level and binding activity to the human CRBPII gene DR-1-like element, as well as CRBPII gene expression.	Tetradecanoylphorbol Acetate	30-61	retinol binding protein 2	Homo sapiens	170-176
19147806-7	2009	Caco-2 BBe cells treated with phorbol 12-myristate 13-acetate, a protein kinase C activator, decreased nuclear HNF-4alpha protein level and binding activity to the human CRBPII gene DR-1-like element, as well as CRBPII gene expression.	Tetradecanoylphorbol Acetate	30-61	retinol binding protein 2	Homo sapiens	212-218
19103313-2	2009	Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) treatment, and can be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL).	Tetradecanoylphorbol Acetate	80-105	GLI family zinc finger 2	Homo sapiens	6-11
19103313-2	2009	Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) treatment, and can be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL).	Tetradecanoylphorbol Acetate	107-110	GLI family zinc finger 2	Homo sapiens	6-11
19110010-5	2009	In these cells, TPA stimulation but not TNFalpha, activated extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	16-19	mitogen-activated protein kinase 1	Homo sapiens	60-97
19110010-5	2009	In these cells, TPA stimulation but not TNFalpha, activated extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	16-19	mitogen-activated protein kinase 1	Homo sapiens	99-102
19110010-6	2009	We demonstrated that the ability of the dexamethasone activated GR mutant to repress TPA-induced NF-kappaB activity was restored in conjunction with ERK1/2 inhibition.	Tetradecanoylphorbol Acetate	85-88	mitogen-activated protein kinase 3	Homo sapiens	149-155
19110010-9	2009	However, TPA treatment alone resulted in much stronger MKP-1 expression in both GRwt and GRR488Q containing cells than that of dexamethasone suggesting that the inability of GRR488Q to inhibit TPA-induced NF-kappaB activity did not involve a lack of MKP-1 expression.	Tetradecanoylphorbol Acetate	9-12	dual specificity phosphatase 1	Homo sapiens	55-60
19244111-2	2009	However, it is not clear whether and how endogenous IFNgamma influences 7,12-dimethylbenz(a)anthracene (DMBA)-induced and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced papilloma development.	Tetradecanoylphorbol Acetate	122-158	interferon gamma	Mus musculus	52-60
18597088-9	2009	RESULTS: EPB inhibited the NF-kappaB-mediated transcription activity induced by tumor necrosis factor-alpha (TNF-alpha) and phorbol myristate acetate (PMA) in MCF-7 cells.	Tetradecanoylphorbol Acetate	124-149	nuclear factor kappa B subunit 1	Homo sapiens	27-36
18597088-9	2009	RESULTS: EPB inhibited the NF-kappaB-mediated transcription activity induced by tumor necrosis factor-alpha (TNF-alpha) and phorbol myristate acetate (PMA) in MCF-7 cells.	Tetradecanoylphorbol Acetate	151-154	nuclear factor kappa B subunit 1	Homo sapiens	27-36
19244111-2	2009	However, it is not clear whether and how endogenous IFNgamma influences 7,12-dimethylbenz(a)anthracene (DMBA)-induced and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced papilloma development.	Tetradecanoylphorbol Acetate	160-163	interferon gamma	Mus musculus	52-60
19244111-3	2009	We found here that IFNgamma expression was markedly up-regulated shortly after DMBA/TPA application to the skin.	Tetradecanoylphorbol Acetate	84-87	interferon gamma	Mus musculus	19-27
19244111-6	2009	IFNgamma acted mainly in the promotion stage of papilloma development by enhancing TPA-induced leukocyte infiltration and epidermal hyperproliferation.	Tetradecanoylphorbol Acetate	83-86	interferon gamma	Mus musculus	0-8
19244111-8	2009	Remarkably, up-regulation of both IL-17 expression in the skin and T helper 17 (Th17) cell number in draining lymph nodes after DMBA/TPA treatment was dependent on IFNgamma signaling.	Tetradecanoylphorbol Acetate	133-136	interferon gamma	Mus musculus	164-172
19101626-3	2009	However, a precise mechanism for C1P-induced activation of cPLA(2)alpha has not been well elucidated; such as the phosphorylation signal caused by the extracellular signal-regulated kinases (ERK1/2) pathway, a downstream of the protein kinase C activation with 4beta-phorbol myristate acetate (PMA), is required or not.	Tetradecanoylphorbol Acetate	294-297	mitogen-activated protein kinase 3	Homo sapiens	191-197
19335688-5	2009	Furthermore, the enhanced expression of CD208 in the perinuclear lesions of IFN-gamma-/TPA-stimulated keratinocytes was observed in vitro.	Tetradecanoylphorbol Acetate	87-90	interferon gamma	Homo sapiens	76-85
19160003-0	2009	Fibronectin promotes the phorbol 12-myristate 13-acetate-induced macrophage differentiation in myeloid leukemia cells.	Tetradecanoylphorbol Acetate	25-56	fibronectin 1	Homo sapiens	0-11
19124542-6	2009	In contrast, the phorbol ester PMA (phorbol-12-myristate-13-acetate, a pharmacological mimic of the downstream mediator diacylglycerol in alpha-adrenergic signalling), caused continuous PKD-dependent HDAC5-GFP nuclear efflux and maintained PKD1-mPlum redistribution.	Tetradecanoylphorbol Acetate	31-34	histone deacetylase 5	Mus musculus	200-205
19112091-3	2009	The effect of RA was dose-dependent, and at the optimal concentration of 1 muM, repression of Fas-induced cell death by the mitogens 12-O-tetradecanoylphorbol 13-acetate (TPA) or Con A was reversed by approximately 50% and 30%, respectively.	Tetradecanoylphorbol Acetate	133-169	latexin	Homo sapiens	75-78
19112091-5	2009	TPA-mediated protection from Fas-induced apoptosis is dependent on ERK and NF-kappaB.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	67-70
19112091-5	2009	TPA-mediated protection from Fas-induced apoptosis is dependent on ERK and NF-kappaB.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	75-84
19124542-6	2009	In contrast, the phorbol ester PMA (phorbol-12-myristate-13-acetate, a pharmacological mimic of the downstream mediator diacylglycerol in alpha-adrenergic signalling), caused continuous PKD-dependent HDAC5-GFP nuclear efflux and maintained PKD1-mPlum redistribution.	Tetradecanoylphorbol Acetate	36-67	histone deacetylase 5	Mus musculus	200-205
18756441-2	2009	We have recently shown that treatment of LNCaP cells with phorbol 12-myristate 13-acetate (PMA) leads to a PKCdelta-mediated autocrine release of death factors, including the cytokines TNFalpha and TRAIL, and that conditioned medium (CM) collected from PMA-treated LNCaP cells promotes the activation of the extrinsic apoptotic cascade.	Tetradecanoylphorbol Acetate	58-89	tumor necrosis factor	Homo sapiens	185-193
19124542-7	2009	In the absence of expressed HDAC, PMA increased histone H3 acetylation and increased MEF2 reporter activity in a PKD-dependent manner, consistent with PKD phosphorylation of endogenous HDAC(s) and reduced nuclear HDAC activity due to HDAC nuclear efflux.	Tetradecanoylphorbol Acetate	34-37	myocyte enhancer factor 2C	Mus musculus	85-89
18756441-2	2009	We have recently shown that treatment of LNCaP cells with phorbol 12-myristate 13-acetate (PMA) leads to a PKCdelta-mediated autocrine release of death factors, including the cytokines TNFalpha and TRAIL, and that conditioned medium (CM) collected from PMA-treated LNCaP cells promotes the activation of the extrinsic apoptotic cascade.	Tetradecanoylphorbol Acetate	58-89	TNF superfamily member 10	Homo sapiens	198-203
18756441-2	2009	We have recently shown that treatment of LNCaP cells with phorbol 12-myristate 13-acetate (PMA) leads to a PKCdelta-mediated autocrine release of death factors, including the cytokines TNFalpha and TRAIL, and that conditioned medium (CM) collected from PMA-treated LNCaP cells promotes the activation of the extrinsic apoptotic cascade.	Tetradecanoylphorbol Acetate	91-94	tumor necrosis factor	Homo sapiens	185-193
18756441-2	2009	We have recently shown that treatment of LNCaP cells with phorbol 12-myristate 13-acetate (PMA) leads to a PKCdelta-mediated autocrine release of death factors, including the cytokines TNFalpha and TRAIL, and that conditioned medium (CM) collected from PMA-treated LNCaP cells promotes the activation of the extrinsic apoptotic cascade.	Tetradecanoylphorbol Acetate	91-94	TNF superfamily member 10	Homo sapiens	198-203
19276187-6	2009	Interestingly, pretreatment with phorbol 12-myristate 13-acetate or transfection of MAPK/ERK kinase/ERK resulting in ERK activation completely attenuated sphingosine-induced p38 MAPK activation.	Tetradecanoylphorbol Acetate	33-64	mitogen-activated protein kinase 14	Homo sapiens	174-177
19258426-5	2009	Pretreatment with NSC 676914 is here shown to repress 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IkappaB-alpha phosphorylation and translocation of p65/50 to the nucleus but not the processing of p52 from p100, suggesting the inhibition of NF-kappaB regulator IKKbeta rather than IKKalpha.	Tetradecanoylphorbol Acetate	54-90	NFKB inhibitor alpha	Homo sapiens	105-118
19258426-5	2009	Pretreatment with NSC 676914 is here shown to repress 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IkappaB-alpha phosphorylation and translocation of p65/50 to the nucleus but not the processing of p52 from p100, suggesting the inhibition of NF-kappaB regulator IKKbeta rather than IKKalpha.	Tetradecanoylphorbol Acetate	92-95	NFKB inhibitor alpha	Homo sapiens	105-118
19258426-5	2009	Pretreatment with NSC 676914 is here shown to repress 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IkappaB-alpha phosphorylation and translocation of p65/50 to the nucleus but not the processing of p52 from p100, suggesting the inhibition of NF-kappaB regulator IKKbeta rather than IKKalpha.	Tetradecanoylphorbol Acetate	92-95	nuclear factor kappa B subunit 2	Homo sapiens	204-207
19258426-7	2009	Induction of IkappaB-alpha phosphorylation by TPA was diminished by pretreatment of NSC 676914 even at 1.1 mumol/L.	Tetradecanoylphorbol Acetate	46-49	NFKB inhibitor alpha	Homo sapiens	13-26
19276187-6	2009	Interestingly, pretreatment with phorbol 12-myristate 13-acetate or transfection of MAPK/ERK kinase/ERK resulting in ERK activation completely attenuated sphingosine-induced p38 MAPK activation.	Tetradecanoylphorbol Acetate	33-64	mitogen-activated protein kinase 1	Homo sapiens	178-182
19020052-3	2009	We transfected the MKP-1 (CS) mutant and control (wild-type, WT) constructs into phorbol 12-myristate 13-acetate (PMA)-activated COS-1 cells.	Tetradecanoylphorbol Acetate	81-112	dual specificity phosphatase 1	Homo sapiens	19-24
19208844-4	2009	The promoter assay showed that MMP-9 promoter activity was suppressed by RECK and that RECK-mediated suppression of MMP-9 promoter activity requires 12-O-tetradecanoylphorbol-13-acetate-responsive element (TRE) and kappaB sites.	Tetradecanoylphorbol Acetate	149-185	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	87-91
18845389-9	2009	The addition of a protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate, rescued PhIP-inhibited TNF-alpha expression in LTA-stimulated cells.	Tetradecanoylphorbol Acetate	52-83	tumor necrosis factor	Mus musculus	108-117
18941116-2	2009	Here we show that U937-derived, chronically infected U1 cells stimulated with phorbol 12-myristate 13-acetate (PMA) express integrins, uPA, and soluble uPAR at levels similar to those of MDMs.	Tetradecanoylphorbol Acetate	78-109	plasminogen activator, urokinase	Homo sapiens	135-138
19033536-2	2009	Previous studies from our laboratory have demonstrated that phorbol ester, PMA (1 microM, 24 h), upregulates butyrate transport and MCT1 protein expression in human intestinal Caco-2 cells.	Tetradecanoylphorbol Acetate	75-78	solute carrier family 16 member 1	Homo sapiens	132-136
19060248-4	2009	We found that Src protein expression and activity was regulated during the normal hair cycle and was increased specifically during the proliferative anagen phase and also in response to the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	206-242	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-17
19033536-4	2009	In the present study, we showed that PMA (0.1 microM, 24 h) increased the MCT1 promoter activity (-871/+91) by approximately fourfold.	Tetradecanoylphorbol Acetate	37-40	solute carrier family 16 member 1	Homo sapiens	74-78
19033536-6	2009	PMA-induced stimulation of MCT1 promoter activity was observed as early as 1 h and persisted until 24 h, suggesting that the effects of PMA are attributable to initial PKC activation.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 16 member 1	Homo sapiens	27-31
19060248-4	2009	We found that Src protein expression and activity was regulated during the normal hair cycle and was increased specifically during the proliferative anagen phase and also in response to the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	244-247	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-17
19060248-5	2009	AZD0530, a selective Src inhibitor, prevented the TPA-induced proliferation of basal keratinocytes both in vivo and in vitro.	Tetradecanoylphorbol Acetate	50-53	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	21-24
19038244-6	2009	In the present study, we determined that andrographolide reduced IL-2 production in Jurkat cells stimulated with phorbol myristate acetate and ionomycin (PMA/Ionomycin).	Tetradecanoylphorbol Acetate	113-138	interleukin 2	Homo sapiens	65-69
18945876-8	2009	In contrast, treatment with phorbol myristate acetate (PMA), a protein kinase C activator, decreased the expression of ACER2 and sphingosine in T-REx HeLa cells, thus enhancing beta1 maturation.	Tetradecanoylphorbol Acetate	55-58	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	177-182
18945876-8	2009	In contrast, treatment with phorbol myristate acetate (PMA), a protein kinase C activator, decreased the expression of ACER2 and sphingosine in T-REx HeLa cells, thus enhancing beta1 maturation.	Tetradecanoylphorbol Acetate	28-53	alkaline ceramidase 2	Homo sapiens	119-124
18945876-8	2009	In contrast, treatment with phorbol myristate acetate (PMA), a protein kinase C activator, decreased the expression of ACER2 and sphingosine in T-REx HeLa cells, thus enhancing beta1 maturation.	Tetradecanoylphorbol Acetate	28-53	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	177-182
18945876-8	2009	In contrast, treatment with phorbol myristate acetate (PMA), a protein kinase C activator, decreased the expression of ACER2 and sphingosine in T-REx HeLa cells, thus enhancing beta1 maturation.	Tetradecanoylphorbol Acetate	55-58	alkaline ceramidase 2	Homo sapiens	119-124
19004007-6	2009	Although the levels of the epidermal growth factor receptors and MSK were similar, the Ras-MAPK pathway was differentially induced by phorbol esters (12-O tetradecanoylphorbol-13-acetate) or epidermal growth factor, with the response of this signaling pathway being cell-type specific.	Tetradecanoylphorbol Acetate	150-186	mitogen-activated protein kinase 3	Homo sapiens	91-95
19038244-6	2009	In the present study, we determined that andrographolide reduced IL-2 production in Jurkat cells stimulated with phorbol myristate acetate and ionomycin (PMA/Ionomycin).	Tetradecanoylphorbol Acetate	154-157	interleukin 2	Homo sapiens	65-69
19038244-9	2009	Using Western blotting, we demonstrated that andrographolide decreased ERK1 and ERK5 phosphorylation induced by anti-CD3 or PMA/Ionomycin.	Tetradecanoylphorbol Acetate	124-127	mitogen-activated protein kinase 3	Homo sapiens	71-75
18848748-4	2009	Oligonol diminished nuclear translocation and DNA binding of nuclear factor-kappaB (NF-kappaB) via blockade of phosphorylation and subsequent degradation of IkappaB alpha in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	174-177	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	157-170
19114653-7	2009	Induction of megakaryocytic differentiation in K562 cells by 12-o-tetradecanoylphorbol-13-acetate markedly increased miR-27a expression, concomitantly with binding of Runx1 to miR-27a regulatory region.	Tetradecanoylphorbol Acetate	61-97	microRNA 27a	Homo sapiens	117-124
19322670-6	2009	Among these constructs, the most responsive promoter (NR1/2) encoded a combination of two GAGACC/SSREs, the Sp1/Egr1 sequence, as well as a TPA response element (TRE).	Tetradecanoylphorbol Acetate	140-143	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	54-59
19118017-1	2009	Transgenic mice that overexpress PKCalpha in the epidermis (K5-PKCalpha mice) exhibit acute CXCR2-mediated intraepidermal neutrophilic inflammation and a strong epidermal hyperplasia in response to application of 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	213-249	protein kinase C, alpha	Mus musculus	33-41
19331173-12	2009	Resveratrol inhibited the PMA-induced NF-kappaB activation and NF-kappaB-dependent luciferase activity.	Tetradecanoylphorbol Acetate	26-29	nuclear factor kappa B subunit 1	Homo sapiens	38-47
18992303-4	2009	Promoter activities of IL-2, nuclear factor of activated T cells (NFAT), and activator protein-1 (AP-1), after 6 h stimulation with PMA and ionomycin, gradually decreased in high glucose cultures to approximately 20% of those in normal glucose at 12 weeks.	Tetradecanoylphorbol Acetate	132-135	interleukin 2	Homo sapiens	23-27
18992303-4	2009	Promoter activities of IL-2, nuclear factor of activated T cells (NFAT), and activator protein-1 (AP-1), after 6 h stimulation with PMA and ionomycin, gradually decreased in high glucose cultures to approximately 20% of those in normal glucose at 12 weeks.	Tetradecanoylphorbol Acetate	132-135	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-96
18992303-4	2009	Promoter activities of IL-2, nuclear factor of activated T cells (NFAT), and activator protein-1 (AP-1), after 6 h stimulation with PMA and ionomycin, gradually decreased in high glucose cultures to approximately 20% of those in normal glucose at 12 weeks.	Tetradecanoylphorbol Acetate	132-135	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-102
19029835-3	2009	Similarly, KD-PKCalpha blocks the apoptotic response elicited by combination of TPA and radiation, whereas expression of constitutively active PKCalpha is sufficient to sensitize cells to radiation alone, without a need to pre-treat the cells with TPA.	Tetradecanoylphorbol Acetate	80-83	protein kinase C alpha	Homo sapiens	14-22
19302552-9	2009	Association of phospho-ERK 1/2 to alpha(1B)-adrenoceptors increased not only in response to agonist but also in response to agents that increase alpha(1B)-adrenoceptor and ERK1/2 phosphorylation [such as endothelin-1, phorbol 12-myristate-13-acetate (PMA) and epidermal growth factor (EGF)]; not surprisingly, PD98059 decreased this effect.	Tetradecanoylphorbol Acetate	218-249	mitogen-activated protein kinase 3	Homo sapiens	23-28
19302552-9	2009	Association of phospho-ERK 1/2 to alpha(1B)-adrenoceptors increased not only in response to agonist but also in response to agents that increase alpha(1B)-adrenoceptor and ERK1/2 phosphorylation [such as endothelin-1, phorbol 12-myristate-13-acetate (PMA) and epidermal growth factor (EGF)]; not surprisingly, PD98059 decreased this effect.	Tetradecanoylphorbol Acetate	218-249	mitogen-activated protein kinase 3	Homo sapiens	172-178
19302552-9	2009	Association of phospho-ERK 1/2 to alpha(1B)-adrenoceptors increased not only in response to agonist but also in response to agents that increase alpha(1B)-adrenoceptor and ERK1/2 phosphorylation [such as endothelin-1, phorbol 12-myristate-13-acetate (PMA) and epidermal growth factor (EGF)]; not surprisingly, PD98059 decreased this effect.	Tetradecanoylphorbol Acetate	218-249	endothelin 1	Homo sapiens	204-216
19118017-1	2009	Transgenic mice that overexpress PKCalpha in the epidermis (K5-PKCalpha mice) exhibit acute CXCR2-mediated intraepidermal neutrophilic inflammation and a strong epidermal hyperplasia in response to application of 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	251-254	protein kinase C, alpha	Mus musculus	33-41
19118017-3	2009	Furthermore, when K5-PKCalpha mice were initiated with 7,12-dimethylbenz(a)anthracene (DMBA) and promoted with a low dose of TPA, 58% of K5-PKCalpha mice developed skin papillomas that progressed to carcinoma, whereas wild-type mice did not develop tumors.	Tetradecanoylphorbol Acetate	125-128	protein kinase C, alpha	Mus musculus	21-29
19118017-3	2009	Furthermore, when K5-PKCalpha mice were initiated with 7,12-dimethylbenz(a)anthracene (DMBA) and promoted with a low dose of TPA, 58% of K5-PKCalpha mice developed skin papillomas that progressed to carcinoma, whereas wild-type mice did not develop tumors.	Tetradecanoylphorbol Acetate	125-128	protein kinase C, alpha	Mus musculus	140-148
19358982-8	2009	In contrast, PMA-treated monocytes bypassed caspase 3, 9 pathways and lead to cathepsin B-dependent necrosis.	Tetradecanoylphorbol Acetate	13-16	caspase 3	Homo sapiens	44-53
18772234-8	2009	Phorbol myristate acetate (PMA) and IFNtau up-regulate COX2 and PG production in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-25	cytochrome c oxidase subunit II	Bos taurus	55-59
18945317-5	2009	TNF-alpha release by epidermal cells induced by lipopolysaccharide, 12-O-tetradecanoyl-phorbol-13-acetate and the contact allergen dinitrochlorobenzene was assessed by the L929 biological assay.	Tetradecanoylphorbol Acetate	68-105	tumor necrosis factor	Rattus norvegicus	0-9
18772234-8	2009	Phorbol myristate acetate (PMA) and IFNtau up-regulate COX2 and PG production in a dose-dependent manner.	Tetradecanoylphorbol Acetate	27-30	cytochrome c oxidase subunit II	Bos taurus	55-59
19228446-1	2009	It was previously found that re-seeding monocyte-derived macrophages (MDM) on polycarbonate-based polyurethanes (PCNUs) in the presence of the protein kinase C (PKC) activator phorbol myristate acetate (PMA) inhibited MDM-mediated degradation of PCNUs synthesized with 1,6-hexane diisocyanate (HDI), as well as esterase activity and monocyte-specific esterase (MSE) protein.	Tetradecanoylphorbol Acetate	176-201	proline rich transmembrane protein 2	Homo sapiens	143-159
19001787-6	2009	RESULTS: The application of TPA shifted the PiCl-induced allergic inflammation from a delayed-type response to a biphasic response, increased the infiltration of eosinophils and mast cells at the inflammatory site, shifted the cytokine milieu from Th1 to Th2 and induced the expression of thymic stromal lymphopoietin in the ear lobes.	Tetradecanoylphorbol Acetate	28-31	negative elongation factor complex member C/D, Th1l	Mus musculus	248-251
19228446-1	2009	It was previously found that re-seeding monocyte-derived macrophages (MDM) on polycarbonate-based polyurethanes (PCNUs) in the presence of the protein kinase C (PKC) activator phorbol myristate acetate (PMA) inhibited MDM-mediated degradation of PCNUs synthesized with 1,6-hexane diisocyanate (HDI), as well as esterase activity and monocyte-specific esterase (MSE) protein.	Tetradecanoylphorbol Acetate	176-201	proline rich transmembrane protein 2	Homo sapiens	161-164
19228446-1	2009	It was previously found that re-seeding monocyte-derived macrophages (MDM) on polycarbonate-based polyurethanes (PCNUs) in the presence of the protein kinase C (PKC) activator phorbol myristate acetate (PMA) inhibited MDM-mediated degradation of PCNUs synthesized with 1,6-hexane diisocyanate (HDI), as well as esterase activity and monocyte-specific esterase (MSE) protein.	Tetradecanoylphorbol Acetate	203-206	proline rich transmembrane protein 2	Homo sapiens	143-159
19228446-1	2009	It was previously found that re-seeding monocyte-derived macrophages (MDM) on polycarbonate-based polyurethanes (PCNUs) in the presence of the protein kinase C (PKC) activator phorbol myristate acetate (PMA) inhibited MDM-mediated degradation of PCNUs synthesized with 1,6-hexane diisocyanate (HDI), as well as esterase activity and monocyte-specific esterase (MSE) protein.	Tetradecanoylphorbol Acetate	203-206	proline rich transmembrane protein 2	Homo sapiens	161-164
20182632-3	2009	The production of IL-2 in siRNA treated cells stimulated with PMA/ionomycin was not affected indicating an involvement of TOM1L in a pathway proximal of TCR and CD28.	Tetradecanoylphorbol Acetate	62-65	interleukin 2	Homo sapiens	18-22
19519169-2	2009	Here we show that an inhibition of NF-kappaB signaling in keratinocytes, via the expression of the super-repressor/ degradation-resistant form of the IkappaBalpha protein (IkappaBalphaDN), interferes with the growth arrest induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	253-289	NFKB inhibitor alpha	Homo sapiens	150-162
19519169-2	2009	Here we show that an inhibition of NF-kappaB signaling in keratinocytes, via the expression of the super-repressor/ degradation-resistant form of the IkappaBalpha protein (IkappaBalphaDN), interferes with the growth arrest induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	291-294	NFKB inhibitor alpha	Homo sapiens	150-162
18758751-0	2009	Involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells.	Tetradecanoylphorbol Acetate	22-25	proline rich transmembrane protein 2	Homo sapiens	15-18
18758751-2	2009	To better understand the mechanisms underlying differentiation-mediated regulation of apoptosis, we have studied the effects of PKC pathway with an activator of the protein kinase C, 12-O-tetradecanoylphorbol-13-acetate (TPA), during hemin-induced erythroid differentiation of K562 erythroleukemia cells.	Tetradecanoylphorbol Acetate	183-219	proline rich transmembrane protein 2	Homo sapiens	128-131
18758751-2	2009	To better understand the mechanisms underlying differentiation-mediated regulation of apoptosis, we have studied the effects of PKC pathway with an activator of the protein kinase C, 12-O-tetradecanoylphorbol-13-acetate (TPA), during hemin-induced erythroid differentiation of K562 erythroleukemia cells.	Tetradecanoylphorbol Acetate	221-224	proline rich transmembrane protein 2	Homo sapiens	128-131
18758751-8	2009	Our data showed that TPA-potentiated apoptosis in hemin-treated K562 cells was rescued by the application of the PKC inhibitors.	Tetradecanoylphorbol Acetate	21-24	proline rich transmembrane protein 2	Homo sapiens	113-116
18758751-9	2009	Taken together, our results suggested the involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells.	Tetradecanoylphorbol Acetate	64-67	proline rich transmembrane protein 2	Homo sapiens	57-60
18931473-2	2009	Specific PKC isoforms are activated and downregulated differentially by gonadotropin-releasing hormone (GnRH) and the phorbol ester TPA.	Tetradecanoylphorbol Acetate	132-135	protein kinase C, alpha	Mus musculus	9-12
20155627-4	2009	In this study, we examined the effect of piceatannol on activation of the nuclear transcription factor NF-kappa B, one of the major transcription factors that regulate proinflammatory COX-2 gene transcription, in human mammary epithelial (MCF-10A) cells treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	286-322	nuclear factor kappa B subunit 1	Homo sapiens	103-113
20155627-4	2009	In this study, we examined the effect of piceatannol on activation of the nuclear transcription factor NF-kappa B, one of the major transcription factors that regulate proinflammatory COX-2 gene transcription, in human mammary epithelial (MCF-10A) cells treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	324-327	nuclear factor kappa B subunit 1	Homo sapiens	103-113
20155627-5	2009	When pretreated to MCF-10A cells, piceatannol markedly inhibited TPA-induced NF-kappa B DNA binding to a greater extent than resveratrol and oxyresveratrol, stilbene analogs structurally related to piceatannol.	Tetradecanoylphorbol Acetate	65-68	nuclear factor kappa B subunit 1	Homo sapiens	77-87
20155627-6	2009	Piceatannol also inhibited TPA-induced phosphorylation and degradation of Ikappa Balpha as well as nuclear translocation of the phosphorylated form of p65, the functionally active subunit of NF-kappa B.	Tetradecanoylphorbol Acetate	27-30	nuclear factor kappa B subunit 1	Homo sapiens	191-201
20155627-7	2009	Likewise, TPA-induced expression of COX-2 was abrogated by piceatannol pretreatment.	Tetradecanoylphorbol Acetate	10-13	prostaglandin-endoperoxide synthase 2	Homo sapiens	36-41
18931473-3	2009	In the present study, focusing mainly on PKC epsilon, the mechanisms underlying the proteasome-dependent downregulation of GnRH-activated PKC epsilon and TPA-sensitive PKC alpha and epsilon isoenzymes were investigated in alphaT3-1 gonadotrope cells.	Tetradecanoylphorbol Acetate	154-157	protein kinase C, alpha	Mus musculus	168-177
18931473-8	2009	CONCLUSION: In alphaT3-1 gonadotrope cells, polyubiquitination is therefore the event triggering GnRH-evoked PKC epsilon desensitization as well as TPA-induced PKC alpha and PKC epsilon downregulations; it precedes the respective isoenzyme"s degradation by the proteasome complex.	Tetradecanoylphorbol Acetate	148-151	protein kinase C, alpha	Mus musculus	160-169
18954258-5	2008	All 3 drugs had an inhibitory effect on IFN-gamma-induced phagosome maturation in phorbolmyristate acetate-differentiated human THP-1 cells.	Tetradecanoylphorbol Acetate	82-106	interferon gamma	Homo sapiens	40-49
18996084-4	2008	Here we show the expression of CatE in primary human B cells and DC, which was only elevated in B cells after induction with phorbol 12-myristate 13-acetate (PMA), resulted in enhanced presentation of tetanus toxin C-fragment (TTC) to the respective T cells.	Tetradecanoylphorbol Acetate	125-156	chemokine (C-C motif) ligand 22	Mus musculus	65-67
18996084-4	2008	Here we show the expression of CatE in primary human B cells and DC, which was only elevated in B cells after induction with phorbol 12-myristate 13-acetate (PMA), resulted in enhanced presentation of tetanus toxin C-fragment (TTC) to the respective T cells.	Tetradecanoylphorbol Acetate	158-161	chemokine (C-C motif) ligand 22	Mus musculus	65-67
19020135-5	2008	We also examined the effects of nicorandil on the ERK activation induced by 4beta-phorbol 12-myristate 13-acetate, an activator of protein kinase C, or ionomycin, a calcium ionophore.	Tetradecanoylphorbol Acetate	76-113	Eph receptor B1	Rattus norvegicus	50-53
19077250-11	2008	The Erk pathway might be involved in TPA-induced migration but not in migration driven by PKCepsilon.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 1	Homo sapiens	4-7
19077250-12	2008	TPA induced phosphorylation of the PKC substrate myristoylated alanine-rich C kinase substrate (MARCKS) which was suppressed by the PKC inhibitors.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	35-38
18975922-0	2008	Phorbol-12-myristate 13-acetate acting through protein kinase Cepsilon induces translocator protein (18-kDa) TSPO gene expression.	Tetradecanoylphorbol Acetate	0-31	translocator protein	Mus musculus	79-99
18975922-0	2008	Phorbol-12-myristate 13-acetate acting through protein kinase Cepsilon induces translocator protein (18-kDa) TSPO gene expression.	Tetradecanoylphorbol Acetate	0-31	translocator protein	Mus musculus	109-113
18975922-3	2008	We analyzed Tspo transcriptional responses to the tumor promoter, phorbol-12-myristate 13-acetate (PMA), in cells with varying TSPO levels.	Tetradecanoylphorbol Acetate	66-97	translocator protein	Mus musculus	12-16
18975922-3	2008	We analyzed Tspo transcriptional responses to the tumor promoter, phorbol-12-myristate 13-acetate (PMA), in cells with varying TSPO levels.	Tetradecanoylphorbol Acetate	99-102	translocator protein	Mus musculus	12-16
18181018-6	2008	Aromatase is expressed in SGBS cells and its expression and activity are strongly stimulated by forskolin (FSK) and phorbol 12-myristate-13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	116-147	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
18941896-0	2008	Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells.	Tetradecanoylphorbol Acetate	58-94	AKT serine/threonine kinase 1	Homo sapiens	37-40
18941896-3	2008	We found that TPA treatment induced SMC apoptosis through the rapid downregulation of Akt phosphorylation.	Tetradecanoylphorbol Acetate	14-17	AKT serine/threonine kinase 1	Homo sapiens	86-89
18941896-4	2008	The inhibition of Akt activation by TPA was markedly reduced by inhibitors of protein phosphatase 2A and proteasome.	Tetradecanoylphorbol Acetate	36-39	AKT serine/threonine kinase 1	Homo sapiens	18-21
18941896-5	2008	Moreover, TPA promoted the ubiquitination of p-Akt, whereas inhibition of TPA-induced PKC activation suppressed the downregulation and ubiquitination of p-Akt.	Tetradecanoylphorbol Acetate	10-13	AKT serine/threonine kinase 1	Homo sapiens	47-50
18941896-5	2008	Moreover, TPA promoted the ubiquitination of p-Akt, whereas inhibition of TPA-induced PKC activation suppressed the downregulation and ubiquitination of p-Akt.	Tetradecanoylphorbol Acetate	74-77	proline rich transmembrane protein 2	Homo sapiens	86-89
18941896-5	2008	Moreover, TPA promoted the ubiquitination of p-Akt, whereas inhibition of TPA-induced PKC activation suppressed the downregulation and ubiquitination of p-Akt.	Tetradecanoylphorbol Acetate	74-77	AKT serine/threonine kinase 1	Homo sapiens	155-158
18941896-6	2008	Taken together, these results demonstrate that TPA triggers inactivation of Akt, at least in part, through PKC and Ubiquitin-proteasome degradation, thereby contributing to SMC apoptosis.	Tetradecanoylphorbol Acetate	47-50	AKT serine/threonine kinase 1	Homo sapiens	76-79
18941896-6	2008	Taken together, these results demonstrate that TPA triggers inactivation of Akt, at least in part, through PKC and Ubiquitin-proteasome degradation, thereby contributing to SMC apoptosis.	Tetradecanoylphorbol Acetate	47-50	proline rich transmembrane protein 2	Homo sapiens	107-110
18982452-6	2008	In addition, increased expression of JNK in the absence of NFkappaB resulted in a significant induction of cell death in oral tumors when either left untreated or treated with TNF-alpha and TPA.	Tetradecanoylphorbol Acetate	190-193	mitogen-activated protein kinase 8	Homo sapiens	37-40
18982452-7	2008	Moreover, when JNK was inhibited by dominant negative JNK (APF), a significant decrease in cell death could be observed in TNF-alpha and TPA treated NFkappaB knock down oral tumors.	Tetradecanoylphorbol Acetate	137-140	mitogen-activated protein kinase 8	Homo sapiens	15-18
18982452-7	2008	Moreover, when JNK was inhibited by dominant negative JNK (APF), a significant decrease in cell death could be observed in TNF-alpha and TPA treated NFkappaB knock down oral tumors.	Tetradecanoylphorbol Acetate	137-140	mitogen-activated protein kinase 8	Homo sapiens	54-57
18982452-7	2008	Moreover, when JNK was inhibited by dominant negative JNK (APF), a significant decrease in cell death could be observed in TNF-alpha and TPA treated NFkappaB knock down oral tumors.	Tetradecanoylphorbol Acetate	137-140	nuclear factor kappa B subunit 1	Homo sapiens	149-157
18181018-6	2008	Aromatase is expressed in SGBS cells and its expression and activity are strongly stimulated by forskolin (FSK) and phorbol 12-myristate-13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	149-152	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	0-9
18181018-7	2008	Consistent with this, FSK and PMA treatment also increased activation of the proximal aromatase promoter, promoter II.	Tetradecanoylphorbol Acetate	30-33	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	86-95
19076642-8	2008	These results suggest that PARG gene expression is modulated by PU.1 during TPA-induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	76-79	poly(ADP-ribose) glycohydrolase	Homo sapiens	27-31
19139002-7	2008	Delphinidin strongly suppressed Raf1 and MEK1 kinase activities and subsequently attenuated TPA-induced phosphorylation of MEK, extracellular signal-regulated kinase (ERK), p90RSK, and MSK.	Tetradecanoylphorbol Acetate	92-95	mitogen-activated protein kinase 1	Mus musculus	128-165
19139002-7	2008	Delphinidin strongly suppressed Raf1 and MEK1 kinase activities and subsequently attenuated TPA-induced phosphorylation of MEK, extracellular signal-regulated kinase (ERK), p90RSK, and MSK.	Tetradecanoylphorbol Acetate	92-95	mitogen-activated protein kinase 1	Mus musculus	167-170
19139002-7	2008	Delphinidin strongly suppressed Raf1 and MEK1 kinase activities and subsequently attenuated TPA-induced phosphorylation of MEK, extracellular signal-regulated kinase (ERK), p90RSK, and MSK.	Tetradecanoylphorbol Acetate	92-95	ribosomal protein S6 kinase, polypeptide 2	Mus musculus	173-179
18820286-3	2008	We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin.	Tetradecanoylphorbol Acetate	71-107	nitric oxide synthase 2, inducible	Mus musculus	142-173
18820286-3	2008	We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin.	Tetradecanoylphorbol Acetate	71-107	nitric oxide synthase 2, inducible	Mus musculus	175-179
18820286-3	2008	We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin.	Tetradecanoylphorbol Acetate	109-112	nitric oxide synthase 2, inducible	Mus musculus	142-173
18820286-3	2008	We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin.	Tetradecanoylphorbol Acetate	109-112	nitric oxide synthase 2, inducible	Mus musculus	175-179
18820286-4	2008	Pretreatment with DDMN has resulted in the reduction of TPA-induced nuclear translocation of the nuclear factor-kappa B (NF-kappaB) subunit.	Tetradecanoylphorbol Acetate	56-59	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-119
18820286-4	2008	Pretreatment with DDMN has resulted in the reduction of TPA-induced nuclear translocation of the nuclear factor-kappa B (NF-kappaB) subunit.	Tetradecanoylphorbol Acetate	56-59	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	121-130
18820286-6	2008	DDMN inhibited TPA-induced phosphorylation and nuclear translocation of the signal transducer and activator of transcription 3.	Tetradecanoylphorbol Acetate	15-18	signal transducer and activator of transcription 3	Mus musculus	76-126
18820286-7	2008	Moreover, DDMN suppressed TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, phosphatidylinositol 3-kinase/Akt and protein kinase C that are upstream of NF-kappaB and activator protien-1.	Tetradecanoylphorbol Acetate	26-29	thymoma viral proto-oncogene 1	Mus musculus	163-166
18820286-7	2008	Moreover, DDMN suppressed TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, phosphatidylinositol 3-kinase/Akt and protein kinase C that are upstream of NF-kappaB and activator protien-1.	Tetradecanoylphorbol Acetate	26-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	209-218
19010898-3	2008	Previous studies showed that c-Jun NH(2) terminal kinase (JNK) is required for 12-O-tetradecanoylphorbol-13-acetate (TPA)- and thapsigargin (TG)-induced apoptosis in the androgen-responsive prostate cancer cell line LNCaP.	Tetradecanoylphorbol Acetate	79-115	mitogen-activated protein kinase 8	Homo sapiens	29-56
19020747-9	2008	DCP production was observed in HepG2 cells that had lost E-cadherin expression in a TPA-dose-dependent manner.	Tetradecanoylphorbol Acetate	84-87	cadherin 1	Homo sapiens	57-67
18719353-8	2008	These results suggest that the activation of two distinct pathways such as Ras-Raf-ERK-TCF pathway and Rho-SRF pathway are responsible for the induction of c-fos by TPA and Ras in mitogenic signaling pathways.	Tetradecanoylphorbol Acetate	165-168	zinc fingers and homeoboxes 2	Mus musculus	79-82
18719353-8	2008	These results suggest that the activation of two distinct pathways such as Ras-Raf-ERK-TCF pathway and Rho-SRF pathway are responsible for the induction of c-fos by TPA and Ras in mitogenic signaling pathways.	Tetradecanoylphorbol Acetate	165-168	mitogen-activated protein kinase 1	Mus musculus	83-86
18719355-10	2008	Overexpression of KLHL31 in COS-7 cells inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).	Tetradecanoylphorbol Acetate	92-95	kelch like family member 31	Homo sapiens	18-24
18778746-5	2008	In this study, we attempted to make clear the mechanism of the phorbol 12-myristate 13-acetate (PMA)-suppressed uptake of glycine in C6 glioma cells which have the native expression of GLYT1.	Tetradecanoylphorbol Acetate	63-94	solute carrier family 6 member 9	Homo sapiens	185-190
18778746-5	2008	In this study, we attempted to make clear the mechanism of the phorbol 12-myristate 13-acetate (PMA)-suppressed uptake of glycine in C6 glioma cells which have the native expression of GLYT1.	Tetradecanoylphorbol Acetate	96-99	solute carrier family 6 member 9	Homo sapiens	185-190
18778746-8	2008	Furthermore, the inhibitory effects of PMA or thymeleatoxin (THX), which is a selective activator of conventional PKC (cPKC), were blocked by the downregulation of all PKCs expressed in C6 cells by long-term incubation with THX, or pretreatment with GF109203X or Go6983, which are broad inhibitors of PKC, or Go6976, a selective inhibitor of cPKC.	Tetradecanoylphorbol Acetate	39-42	protein kinase C alpha	Homo sapiens	114-117
18778746-8	2008	Furthermore, the inhibitory effects of PMA or thymeleatoxin (THX), which is a selective activator of conventional PKC (cPKC), were blocked by the downregulation of all PKCs expressed in C6 cells by long-term incubation with THX, or pretreatment with GF109203X or Go6983, which are broad inhibitors of PKC, or Go6976, a selective inhibitor of cPKC.	Tetradecanoylphorbol Acetate	39-42	protein kinase C alpha	Homo sapiens	120-123
19134409-6	2008	In PMA and PKCalpha-asODN treated group, the level of p-PKCalpha decreased, the expression of ERK1/2, p-ERK1/2 and the expression of cyclinD1, P21(cip1) decreased correspondingly (the A value % control was 1.23 +/- 0.19, 1.34 +/- 0.18, 1.52 +/- 0.20, 1.45 +/- 0.18 and 1.49 +/- 0.18 respectively; q value was 7.49, 3.58, 5.97, 6.06 and 15.65 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (21.2 +/- 2.8)%, A(490) value was 0.51 +/- 0.04; q = 6.07, 12.63; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	mitogen-activated protein kinase 3	Homo sapiens	94-100
19134409-6	2008	In PMA and PKCalpha-asODN treated group, the level of p-PKCalpha decreased, the expression of ERK1/2, p-ERK1/2 and the expression of cyclinD1, P21(cip1) decreased correspondingly (the A value % control was 1.23 +/- 0.19, 1.34 +/- 0.18, 1.52 +/- 0.20, 1.45 +/- 0.18 and 1.49 +/- 0.18 respectively; q value was 7.49, 3.58, 5.97, 6.06 and 15.65 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (21.2 +/- 2.8)%, A(490) value was 0.51 +/- 0.04; q = 6.07, 12.63; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	mitogen-activated protein kinase 3	Homo sapiens	104-110
19134409-6	2008	In PMA and PKCalpha-asODN treated group, the level of p-PKCalpha decreased, the expression of ERK1/2, p-ERK1/2 and the expression of cyclinD1, P21(cip1) decreased correspondingly (the A value % control was 1.23 +/- 0.19, 1.34 +/- 0.18, 1.52 +/- 0.20, 1.45 +/- 0.18 and 1.49 +/- 0.18 respectively; q value was 7.49, 3.58, 5.97, 6.06 and 15.65 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (21.2 +/- 2.8)%, A(490) value was 0.51 +/- 0.04; q = 6.07, 12.63; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	cyclin dependent kinase inhibitor 1A	Homo sapiens	143-146
19134409-6	2008	In PMA and PKCalpha-asODN treated group, the level of p-PKCalpha decreased, the expression of ERK1/2, p-ERK1/2 and the expression of cyclinD1, P21(cip1) decreased correspondingly (the A value % control was 1.23 +/- 0.19, 1.34 +/- 0.18, 1.52 +/- 0.20, 1.45 +/- 0.18 and 1.49 +/- 0.18 respectively; q value was 7.49, 3.58, 5.97, 6.06 and 15.65 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (21.2 +/- 2.8)%, A(490) value was 0.51 +/- 0.04; q = 6.07, 12.63; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	cyclin dependent kinase inhibitor 1A	Homo sapiens	147-151
19134409-7	2008	In PMA and U0126 treated group, the level of p-PKCalpha had no significant change (A value was1.99 +/- 0.18, q = 0.94, P &gt; 0.05), but the levels of ERK1/2, p-ERK1/2 decreased, the expression of cyclinD1, P21(cip1) reduced (the A value % control was 0.95 +/- 0.21, 1.15 +/- 0.19, 1.37 +/- 0.15 and 1.96 +/- 0.21 respectively; q value was 7.79, 9.16, 6.92 and 11.16 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (22.0 +/- 3.2)%, A(490) value was 0.49 +/- 0.03; q = 5.51, 13.45; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	mitogen-activated protein kinase 3	Homo sapiens	151-157
19134409-7	2008	In PMA and U0126 treated group, the level of p-PKCalpha had no significant change (A value was1.99 +/- 0.18, q = 0.94, P &gt; 0.05), but the levels of ERK1/2, p-ERK1/2 decreased, the expression of cyclinD1, P21(cip1) reduced (the A value % control was 0.95 +/- 0.21, 1.15 +/- 0.19, 1.37 +/- 0.15 and 1.96 +/- 0.21 respectively; q value was 7.79, 9.16, 6.92 and 11.16 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (22.0 +/- 3.2)%, A(490) value was 0.49 +/- 0.03; q = 5.51, 13.45; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	mitogen-activated protein kinase 3	Homo sapiens	161-167
19134409-7	2008	In PMA and U0126 treated group, the level of p-PKCalpha had no significant change (A value was1.99 +/- 0.18, q = 0.94, P &gt; 0.05), but the levels of ERK1/2, p-ERK1/2 decreased, the expression of cyclinD1, P21(cip1) reduced (the A value % control was 0.95 +/- 0.21, 1.15 +/- 0.19, 1.37 +/- 0.15 and 1.96 +/- 0.21 respectively; q value was 7.79, 9.16, 6.92 and 11.16 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (22.0 +/- 3.2)%, A(490) value was 0.49 +/- 0.03; q = 5.51, 13.45; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	cyclin dependent kinase inhibitor 1A	Homo sapiens	207-210
19134409-7	2008	In PMA and U0126 treated group, the level of p-PKCalpha had no significant change (A value was1.99 +/- 0.18, q = 0.94, P &gt; 0.05), but the levels of ERK1/2, p-ERK1/2 decreased, the expression of cyclinD1, P21(cip1) reduced (the A value % control was 0.95 +/- 0.21, 1.15 +/- 0.19, 1.37 +/- 0.15 and 1.96 +/- 0.21 respectively; q value was 7.79, 9.16, 6.92 and 11.16 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (22.0 +/- 3.2)%, A(490) value was 0.49 +/- 0.03; q = 5.51, 13.45; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	cyclin dependent kinase inhibitor 1A	Homo sapiens	211-215
19010898-3	2008	Previous studies showed that c-Jun NH(2) terminal kinase (JNK) is required for 12-O-tetradecanoylphorbol-13-acetate (TPA)- and thapsigargin (TG)-induced apoptosis in the androgen-responsive prostate cancer cell line LNCaP.	Tetradecanoylphorbol Acetate	79-115	mitogen-activated protein kinase 8	Homo sapiens	58-61
19010898-3	2008	Previous studies showed that c-Jun NH(2) terminal kinase (JNK) is required for 12-O-tetradecanoylphorbol-13-acetate (TPA)- and thapsigargin (TG)-induced apoptosis in the androgen-responsive prostate cancer cell line LNCaP.	Tetradecanoylphorbol Acetate	117-120	mitogen-activated protein kinase 8	Homo sapiens	29-56
19010898-3	2008	Previous studies showed that c-Jun NH(2) terminal kinase (JNK) is required for 12-O-tetradecanoylphorbol-13-acetate (TPA)- and thapsigargin (TG)-induced apoptosis in the androgen-responsive prostate cancer cell line LNCaP.	Tetradecanoylphorbol Acetate	117-120	mitogen-activated protein kinase 8	Homo sapiens	58-61
19010898-4	2008	Androgens protect LNCaP cells from TPA-induced or TG-induced apoptosis via down-regulation of JNK activation.	Tetradecanoylphorbol Acetate	35-38	mitogen-activated protein kinase 8	Homo sapiens	94-97
19010898-7	2008	Ectopic expression of wild-type VHR, but not a catalytically inactive mutant, interfered with TPA- and TG-induced apoptosis.	Tetradecanoylphorbol Acetate	94-97	dual specificity phosphatase 3	Homo sapiens	32-35
19010898-8	2008	Consistently, small interfering RNA-mediated knockdown of endogenous VHR increased apoptosis in response to TPA or TG in the presence of androgens.	Tetradecanoylphorbol Acetate	108-111	dual specificity phosphatase 3	Homo sapiens	69-72
18552380-6	2008	However, IFN-gamma was undetectable unless cells were first stimulated in vitro with PMA and ionomycin, which yielded IFN-gamma in 25% of cells.	Tetradecanoylphorbol Acetate	85-88	interferon gamma	Homo sapiens	9-18
18954528-4	2008	The deregulation of 17AAG and phorbol 12-myristate 13-acetate (PMA) on the IL-6 gene was determined by ELISA and transient gene expression assays using an IL-6 reporter vector.	Tetradecanoylphorbol Acetate	30-61	interleukin 6	Homo sapiens	75-79
18954528-4	2008	The deregulation of 17AAG and phorbol 12-myristate 13-acetate (PMA) on the IL-6 gene was determined by ELISA and transient gene expression assays using an IL-6 reporter vector.	Tetradecanoylphorbol Acetate	63-66	interleukin 6	Homo sapiens	75-79
18954528-4	2008	The deregulation of 17AAG and phorbol 12-myristate 13-acetate (PMA) on the IL-6 gene was determined by ELISA and transient gene expression assays using an IL-6 reporter vector.	Tetradecanoylphorbol Acetate	63-66	interleukin 6	Homo sapiens	155-159
18713840-8	2008	Consistently, insulin was also found to induce the phosphorylation of TR3 and abolish 12-O-tetradecanoylphorbol-13-acetate-induced mitochondrial localization, which was dependent upon the activation of the phophatidylinositol-3-OH-kinase-Akt signaling pathway.	Tetradecanoylphorbol Acetate	86-122	insulin	Homo sapiens	14-21
18713840-8	2008	Consistently, insulin was also found to induce the phosphorylation of TR3 and abolish 12-O-tetradecanoylphorbol-13-acetate-induced mitochondrial localization, which was dependent upon the activation of the phophatidylinositol-3-OH-kinase-Akt signaling pathway.	Tetradecanoylphorbol Acetate	86-122	AKT serine/threonine kinase 1	Homo sapiens	238-241
18552380-6	2008	However, IFN-gamma was undetectable unless cells were first stimulated in vitro with PMA and ionomycin, which yielded IFN-gamma in 25% of cells.	Tetradecanoylphorbol Acetate	85-88	interferon gamma	Homo sapiens	118-127
18496814-5	2008	In this study, the effect of wogonin on phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression was investigated.	Tetradecanoylphorbol Acetate	40-71	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-91
18936204-5	2008	Here, we report that in colon cancer HT-29 cells, RA (5, 10, and 20 micromol/L) reduced the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 promoter activity (P &lt; 0.05) and protein levels (P &lt; 0.05).	Tetradecanoylphorbol Acetate	92-128	prostaglandin-endoperoxide synthase 2	Homo sapiens	143-148
18936204-5	2008	Here, we report that in colon cancer HT-29 cells, RA (5, 10, and 20 micromol/L) reduced the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 promoter activity (P &lt; 0.05) and protein levels (P &lt; 0.05).	Tetradecanoylphorbol Acetate	130-133	prostaglandin-endoperoxide synthase 2	Homo sapiens	143-148
18496814-5	2008	In this study, the effect of wogonin on phorbol 12-myristate 13-acetate (PMA)-induced COX-2 expression was investigated.	Tetradecanoylphorbol Acetate	73-76	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-91
18496814-6	2008	It showed that wogonin inhibited PMA-induced COX-2 protein and mRNA levels in human lung epithelial cancer cells, and the mechanism of this inhibition was at the transcriptional level by using COX-2 gene promoter assay.	Tetradecanoylphorbol Acetate	33-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	45-50
18496814-6	2008	It showed that wogonin inhibited PMA-induced COX-2 protein and mRNA levels in human lung epithelial cancer cells, and the mechanism of this inhibition was at the transcriptional level by using COX-2 gene promoter assay.	Tetradecanoylphorbol Acetate	33-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	193-198
18496814-7	2008	Among various signal inhibitors, the mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor U0126 also inhibited PMA-induced COX-2 expression and COX-2 promoter activation.	Tetradecanoylphorbol Acetate	121-124	prostaglandin-endoperoxide synthase 2	Homo sapiens	133-138
18755856-6	2008	Furthermore, phorbol 12-myristate 13-acetate , a PKC activator, induces the phosphorylation of endogenous FXR in HepG2 cells and PKCalpha phosphorylates in vitro FXR in its DNA-binding domain on S135 and S154.	Tetradecanoylphorbol Acetate	13-44	protein kinase C alpha	Homo sapiens	49-52
18496814-7	2008	Among various signal inhibitors, the mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor U0126 also inhibited PMA-induced COX-2 expression and COX-2 promoter activation.	Tetradecanoylphorbol Acetate	121-124	prostaglandin-endoperoxide synthase 2	Homo sapiens	154-159
18755856-6	2008	Furthermore, phorbol 12-myristate 13-acetate , a PKC activator, induces the phosphorylation of endogenous FXR in HepG2 cells and PKCalpha phosphorylates in vitro FXR in its DNA-binding domain on S135 and S154.	Tetradecanoylphorbol Acetate	13-44	protein kinase C alpha	Homo sapiens	129-137
18755689-6	2008	Phorbol 12-myristate 13-acetate overcame the inhibitory effect of P2Y12 receptor blockade on PKC activation but not on Rap1b activation and platelet aggregation.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	93-96
18682265-4	2008	Considering that PMA prevents the inhibitory effect of Ado on Ang II-stimulated Na(+)-ATPase and PKC activities, it is likely that the PMA-induced effect, i.e. PKC activation, is downstream of the target for Ado-induced reversion of Ang II stimulation of Na(+)-ATPase activity.	Tetradecanoylphorbol Acetate	17-20	angiotensinogen	Homo sapiens	62-68
18682265-4	2008	Considering that PMA prevents the inhibitory effect of Ado on Ang II-stimulated Na(+)-ATPase and PKC activities, it is likely that the PMA-induced effect, i.e. PKC activation, is downstream of the target for Ado-induced reversion of Ang II stimulation of Na(+)-ATPase activity.	Tetradecanoylphorbol Acetate	17-20	angiotensinogen	Homo sapiens	233-239
18682265-4	2008	Considering that PMA prevents the inhibitory effect of Ado on Ang II-stimulated Na(+)-ATPase and PKC activities, it is likely that the PMA-induced effect, i.e. PKC activation, is downstream of the target for Ado-induced reversion of Ang II stimulation of Na(+)-ATPase activity.	Tetradecanoylphorbol Acetate	135-138	angiotensinogen	Homo sapiens	62-68
18682265-4	2008	Considering that PMA prevents the inhibitory effect of Ado on Ang II-stimulated Na(+)-ATPase and PKC activities, it is likely that the PMA-induced effect, i.e. PKC activation, is downstream of the target for Ado-induced reversion of Ang II stimulation of Na(+)-ATPase activity.	Tetradecanoylphorbol Acetate	135-138	angiotensinogen	Homo sapiens	233-239
18693254-4	2008	Treatment of HL60 human leukemic cells or p57/coronin-1-transfected HEK293 cells with phorbol 12-myristate 13-acetate (PMA) reduced the association of p57/coronin-1 with the actin cytoskeleton, as indicated by cell fractionation experiments and by fluorescence microscopic observation.	Tetradecanoylphorbol Acetate	86-117	coronin 1A	Homo sapiens	42-45
18693254-4	2008	Treatment of HL60 human leukemic cells or p57/coronin-1-transfected HEK293 cells with phorbol 12-myristate 13-acetate (PMA) reduced the association of p57/coronin-1 with the actin cytoskeleton, as indicated by cell fractionation experiments and by fluorescence microscopic observation.	Tetradecanoylphorbol Acetate	86-117	coronin 1A	Homo sapiens	46-55
18693254-4	2008	Treatment of HL60 human leukemic cells or p57/coronin-1-transfected HEK293 cells with phorbol 12-myristate 13-acetate (PMA) reduced the association of p57/coronin-1 with the actin cytoskeleton, as indicated by cell fractionation experiments and by fluorescence microscopic observation.	Tetradecanoylphorbol Acetate	86-117	coronin 1A	Homo sapiens	151-154
18693254-4	2008	Treatment of HL60 human leukemic cells or p57/coronin-1-transfected HEK293 cells with phorbol 12-myristate 13-acetate (PMA) reduced the association of p57/coronin-1 with the actin cytoskeleton, as indicated by cell fractionation experiments and by fluorescence microscopic observation.	Tetradecanoylphorbol Acetate	86-117	coronin 1A	Homo sapiens	155-164
18693254-4	2008	Treatment of HL60 human leukemic cells or p57/coronin-1-transfected HEK293 cells with phorbol 12-myristate 13-acetate (PMA) reduced the association of p57/coronin-1 with the actin cytoskeleton, as indicated by cell fractionation experiments and by fluorescence microscopic observation.	Tetradecanoylphorbol Acetate	119-122	coronin 1A	Homo sapiens	42-45
18693254-4	2008	Treatment of HL60 human leukemic cells or p57/coronin-1-transfected HEK293 cells with phorbol 12-myristate 13-acetate (PMA) reduced the association of p57/coronin-1 with the actin cytoskeleton, as indicated by cell fractionation experiments and by fluorescence microscopic observation.	Tetradecanoylphorbol Acetate	119-122	coronin 1A	Homo sapiens	46-55
18693254-4	2008	Treatment of HL60 human leukemic cells or p57/coronin-1-transfected HEK293 cells with phorbol 12-myristate 13-acetate (PMA) reduced the association of p57/coronin-1 with the actin cytoskeleton, as indicated by cell fractionation experiments and by fluorescence microscopic observation.	Tetradecanoylphorbol Acetate	119-122	coronin 1A	Homo sapiens	151-154
18693254-4	2008	Treatment of HL60 human leukemic cells or p57/coronin-1-transfected HEK293 cells with phorbol 12-myristate 13-acetate (PMA) reduced the association of p57/coronin-1 with the actin cytoskeleton, as indicated by cell fractionation experiments and by fluorescence microscopic observation.	Tetradecanoylphorbol Acetate	119-122	coronin 1A	Homo sapiens	155-164
18693254-8	2008	By affinity chromatographic analysis using anti-p57/coronin-1 antibody-conjugated Sepharose, p57/coronin-1 derived from PMA-treated HL60 cells showed lower affinity for actin than that from untreated cells.	Tetradecanoylphorbol Acetate	120-123	coronin 1A	Homo sapiens	48-51
18693254-8	2008	By affinity chromatographic analysis using anti-p57/coronin-1 antibody-conjugated Sepharose, p57/coronin-1 derived from PMA-treated HL60 cells showed lower affinity for actin than that from untreated cells.	Tetradecanoylphorbol Acetate	120-123	coronin 1A	Homo sapiens	52-61
18693254-8	2008	By affinity chromatographic analysis using anti-p57/coronin-1 antibody-conjugated Sepharose, p57/coronin-1 derived from PMA-treated HL60 cells showed lower affinity for actin than that from untreated cells.	Tetradecanoylphorbol Acetate	120-123	coronin 1A	Homo sapiens	93-96
18693254-8	2008	By affinity chromatographic analysis using anti-p57/coronin-1 antibody-conjugated Sepharose, p57/coronin-1 derived from PMA-treated HL60 cells showed lower affinity for actin than that from untreated cells.	Tetradecanoylphorbol Acetate	120-123	coronin 1A	Homo sapiens	97-106
18922899-8	2008	CD34, considered a marker for both KSCs and skin cancer stem cells, and Rac1, a key gene stimulating KSC self-renewal, were greatly increased in tumors produced by arsenic plus TPA exposure versus TPA alone, and both were elevated in arsenic-treated fetal skin.	Tetradecanoylphorbol Acetate	177-180	CD34 molecule	Homo sapiens	0-4
18800802-3	2008	TPA was topically applied to the shaven backs of ICR mice with or without CS (1 or 2 mg) for 4 h. The results demonstrated that CS suppressed TPA-induced edema and reduced the expression of cyclooxygenase-2, vascular cell adhesion molecule-1, and Akt signaling in mouse skin.	Tetradecanoylphorbol Acetate	0-3	thymoma viral proto-oncogene 1	Mus musculus	247-250
18922899-9	2008	Greatly increased numbers of CD34-positive probable cancer stem cells and marked overexpression of RAC1 protein occurred in tumors induced by arsenic plus TPA compared with TPA alone.	Tetradecanoylphorbol Acetate	155-158	CD34 molecule	Homo sapiens	29-33
18922899-9	2008	Greatly increased numbers of CD34-positive probable cancer stem cells and marked overexpression of RAC1 protein occurred in tumors induced by arsenic plus TPA compared with TPA alone.	Tetradecanoylphorbol Acetate	173-176	CD34 molecule	Homo sapiens	29-33
18684225-3	2008	Concanavalin A induced expression of IL-2 mRNA and production of IL-2, and the combination of thapsigargin and phorbol myristate acetate induced expression of IL-4 and IL-10 mRNAs and production of IL-4 and IL-10.	Tetradecanoylphorbol Acetate	111-136	interleukin 4	Homo sapiens	159-163
18599389-0	2008	Suppression of EDAG gene expression by phorbol 12-myristate 13-acetate is mediated through down-regulation of GATA-1.	Tetradecanoylphorbol Acetate	39-70	hemogen	Homo sapiens	15-19
18599389-0	2008	Suppression of EDAG gene expression by phorbol 12-myristate 13-acetate is mediated through down-regulation of GATA-1.	Tetradecanoylphorbol Acetate	39-70	GATA binding protein 1	Homo sapiens	110-116
18684225-3	2008	Concanavalin A induced expression of IL-2 mRNA and production of IL-2, and the combination of thapsigargin and phorbol myristate acetate induced expression of IL-4 and IL-10 mRNAs and production of IL-4 and IL-10.	Tetradecanoylphorbol Acetate	111-136	interleukin 4	Homo sapiens	198-202
18581203-4	2008	AVP also activated extracellular signal-regulated kinase 1/2 (ERK1/2) as assessed by MBP phosphotransferase activity (5.1 +/- 0.6 fold over basal level, P &lt; or = 0.05) and Western blot analysis, and effects were mimicked by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but abolished by inhibiting cellular PKC through chronic PMA incubation.	Tetradecanoylphorbol Acetate	261-292	arginine vasopressin	Rattus norvegicus	0-3
18687326-6	2008	The release of PI-sEGFR from MDA-MB-468 cells is enhanced by phorbol 12-myristate 13-acetate, heat-inactivated fetal bovine serum, pervanadate, and EGFR ligands (i.e., EGF and TGF-alpha).	Tetradecanoylphorbol Acetate	61-92	epidermal growth factor receptor	Homo sapiens	19-23
18647223-3	2008	OBJECTIVES: The aims of the present study were to investigate whether t-PA gene expression is regulated by retinoids and the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) in human astrocytes, and to study whether t-PA is stored and subject to regulated release from these cells, as with endothelial cells.	Tetradecanoylphorbol Acetate	158-189	plasminogen activator, tissue type	Homo sapiens	70-74
18647223-3	2008	OBJECTIVES: The aims of the present study were to investigate whether t-PA gene expression is regulated by retinoids and the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) in human astrocytes, and to study whether t-PA is stored and subject to regulated release from these cells, as with endothelial cells.	Tetradecanoylphorbol Acetate	191-194	plasminogen activator, tissue type	Homo sapiens	70-74
18647223-3	2008	OBJECTIVES: The aims of the present study were to investigate whether t-PA gene expression is regulated by retinoids and the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) in human astrocytes, and to study whether t-PA is stored and subject to regulated release from these cells, as with endothelial cells.	Tetradecanoylphorbol Acetate	191-194	plasminogen activator, tissue type	Homo sapiens	238-242
18581203-4	2008	AVP also activated extracellular signal-regulated kinase 1/2 (ERK1/2) as assessed by MBP phosphotransferase activity (5.1 +/- 0.6 fold over basal level, P &lt; or = 0.05) and Western blot analysis, and effects were mimicked by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but abolished by inhibiting cellular PKC through chronic PMA incubation.	Tetradecanoylphorbol Acetate	294-297	arginine vasopressin	Rattus norvegicus	0-3
18710248-4	2008	Anthocyanidins suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) mRNAs in TPA-stimulated HT-29 cells.	Tetradecanoylphorbol Acetate	103-106	prostaglandin-endoperoxide synthase 2	Homo sapiens	26-42
18647594-0	2008	Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase 1	Homo sapiens	44-47
18647594-0	2008	Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase 3	Homo sapiens	52-58
18710248-4	2008	Anthocyanidins suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) mRNAs in TPA-stimulated HT-29 cells.	Tetradecanoylphorbol Acetate	103-106	nitric oxide synthase 2	Homo sapiens	55-86
18710248-4	2008	Anthocyanidins suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) mRNAs in TPA-stimulated HT-29 cells.	Tetradecanoylphorbol Acetate	103-106	nitric oxide synthase 2	Homo sapiens	88-92
18647637-6	2008	These findings indicate that Ptprz is a physiological target for activity-dependent proteolytic processing by the tPA/plasmin system, and suggest that the proteolytic cleavage is involved in the functional processes of the synapses during learning and memory.	Tetradecanoylphorbol Acetate	114-117	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	29-34
18541361-5	2008	Moreover, PMA evoked a significant increase in the levels of the cell cycle regulators p21Waf1/Cip1 and p27Kip1.	Tetradecanoylphorbol Acetate	10-13	cyclin dependent kinase inhibitor 1A	Homo sapiens	95-99
18541361-8	2008	PMA stimulated the translocation of protein kinase C (PKC) alpha, betaI and delta isoforms to the cell membrane.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	36-64
18621736-9	2008	By using RNA interference, we demonstrate that inhibition of RACK1 expression diminishes the phorbol 12-myristate 13-acetate-dependent translocation of ADAM12 to membranes of hepatic stellate cells.	Tetradecanoylphorbol Acetate	93-124	ADAM metallopeptidase domain 12	Homo sapiens	152-158
18541361-12	2008	In addition, PMA inhibited FRO, ARO and ML-1 cell migration toward serum.	Tetradecanoylphorbol Acetate	13-16	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	32-35
18768832-8	2008	Specific Abs against Rab27a inhibited Ca(2+) and GTP-gamma-S activation and PMA-induced exocytosis of CD66b-enriched tertiary and specific granules in electropermeabilized neutrophils, whereas secretion of CD63-enriched azurophil granules was scarcely affected.	Tetradecanoylphorbol Acetate	76-79	CEA cell adhesion molecule 8	Homo sapiens	102-107
18635599-7	2008	We show that lipid rafts are required for enterocyte migration, that IFN displaces Cx43 from lipid rafts, and that the phorbol ester phorbol 12-myristate 13-acetate (PMA) restores Cx43 to lipid rafts after treatment with IFN in a protein kinase C-dependent manner.	Tetradecanoylphorbol Acetate	133-164	interferon alpha 1	Homo sapiens	221-224
18601906-0	2008	The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis.	Tetradecanoylphorbol Acetate	52-55	gap junction protein, alpha 1	Rattus norvegicus	28-38
18601906-6	2008	Treatment of IAR20 rat liver epithelial cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) or epidermal growth factor (EGF) caused a rapid increase in the solubility of Cx43 in Triton X-100.	Tetradecanoylphorbol Acetate	51-87	gap junction protein, alpha 1	Rattus norvegicus	172-176
18601906-6	2008	Treatment of IAR20 rat liver epithelial cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) or epidermal growth factor (EGF) caused a rapid increase in the solubility of Cx43 in Triton X-100.	Tetradecanoylphorbol Acetate	89-92	gap junction protein, alpha 1	Rattus norvegicus	172-176
18601906-8	2008	The data suggest that loss of the detergent resistance of Cx43 is an early step in TPA- and EGF-induced endocytosis of gap junctions.	Tetradecanoylphorbol Acetate	83-86	gap junction protein, alpha 1	Rattus norvegicus	58-62
18496024-9	2008	CONCLUSIONS: Th2- and Th1-adjuvant activities can be quantitatively evaluated by using PMA-treated THP-1 cells and PMA-treated/forskolin-stimulated THP-1 cells, respectively.	Tetradecanoylphorbol Acetate	87-90	GLI family zinc finger 2	Homo sapiens	99-104
18496024-9	2008	CONCLUSIONS: Th2- and Th1-adjuvant activities can be quantitatively evaluated by using PMA-treated THP-1 cells and PMA-treated/forskolin-stimulated THP-1 cells, respectively.	Tetradecanoylphorbol Acetate	115-118	GLI family zinc finger 2	Homo sapiens	148-153
18599584-8	2008	PMA-induced macrophages load iron dextran and enhance ILI response and TNF-alpha release.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	71-80
18635599-7	2008	We show that lipid rafts are required for enterocyte migration, that IFN displaces Cx43 from lipid rafts, and that the phorbol ester phorbol 12-myristate 13-acetate (PMA) restores Cx43 to lipid rafts after treatment with IFN in a protein kinase C-dependent manner.	Tetradecanoylphorbol Acetate	166-169	interferon alpha 1	Homo sapiens	221-224
18668201-5	2008	ERalpha and ERbeta interact with NFAT3 independently of the NFAT agonists phorbol myristate acetate (PMA) and ionomycin, and ERalpha is recruited to an NFAT3 target gene promoter.	Tetradecanoylphorbol Acetate	74-99	nuclear factor of activated T cells 3	Homo sapiens	33-38
18717683-8	2008	Phosphorylation was greatly reduced by GF109203X and by overexposure of keratinocytes to phorbol 12-myristate 13-acetate, indicating the participation of protein kinase C. B(1)R stimulation did not increase [Ca(2+)]i, but triggered EGFR transactivation, an event that involved phosphorylation of Tyr(845), Tyr(992) and Tyr(1068) of EGFR.	Tetradecanoylphorbol Acetate	89-120	bradykinin receptor B1	Homo sapiens	172-177
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	190-193	mitogen-activated protein kinase 1	Homo sapiens	106-143
18628248-4	2008	Application of QUE significantly suppressed TPA-induced activation of the PKCdelta/ERK/AP-1-signaling cascade.	Tetradecanoylphorbol Acetate	44-47	mitogen-activated protein kinase 1	Homo sapiens	83-86
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	190-193	mitogen-activated protein kinase 1	Homo sapiens	145-148
18668201-5	2008	ERalpha and ERbeta interact with NFAT3 independently of the NFAT agonists phorbol myristate acetate (PMA) and ionomycin, and ERalpha is recruited to an NFAT3 target gene promoter.	Tetradecanoylphorbol Acetate	101-104	estrogen receptor 1	Homo sapiens	0-7
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	190-193	mitogen-activated protein kinase 1	Homo sapiens	358-361
18668201-5	2008	ERalpha and ERbeta interact with NFAT3 independently of the NFAT agonists phorbol myristate acetate (PMA) and ionomycin, and ERalpha is recruited to an NFAT3 target gene promoter.	Tetradecanoylphorbol Acetate	101-104	nuclear factor of activated T cells 3	Homo sapiens	33-38
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	216-219	mitogen-activated protein kinase 1	Homo sapiens	145-148
18408893-7	2008	OT blocked the COX-2 expression induced by phorbol 12-myristate 13-acetate in a dose-dependent manner and induced apoptosis in HT-29 cancer cells, and suppressed iNOS activation in RAW264.7 macrophages.	Tetradecanoylphorbol Acetate	43-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
18663158-5	2008	Here we report that caveolin-dependent internalization is involved in PKC-epsilon-mediated inhibition of vascular K(ATP) channels (Kir6.1 and SUR2B) by phorbol 12-myristate 13-acetate or angiotensin II in human embryonic kidney 293 cells and human dermal vascular smooth muscle cells.	Tetradecanoylphorbol Acetate	152-183	caveolin 1	Homo sapiens	20-28
18544595-4	2008	METHODS: THP-1 monocytes were differentiated with phorbol myristate acetate (PMA) and compared with unstimulated cells for: (i) moxifloxacin and levofloxacin accumulation; and (ii) activity against phagocytosed L. monocytogenes and S. aureus (5 h contact).	Tetradecanoylphorbol Acetate	77-80	GLI family zinc finger 2	Homo sapiens	9-14
18602101-3	2008	We find here that morphological activation of endothelial cells by phorbol 12-myristate 13-acetate (PMA) resulted in membrane-type 1 matrix metalloproteinase (MT1-MMP) -mediated solubilization of latent TGF-beta complexes from the ECM by proteolytic processing of LTBP-1.	Tetradecanoylphorbol Acetate	67-98	transforming growth factor beta 1	Homo sapiens	203-211
18427547-5	2008	In addition, the ectopic overexpression of hSpry2 in HT cells drastically reduced the activation of ERK upon phorbol 12-myristate-13-acetate stimulation.	Tetradecanoylphorbol Acetate	109-140	sprouty RTK signaling antagonist 2	Homo sapiens	43-49
18427547-5	2008	In addition, the ectopic overexpression of hSpry2 in HT cells drastically reduced the activation of ERK upon phorbol 12-myristate-13-acetate stimulation.	Tetradecanoylphorbol Acetate	109-140	mitogen-activated protein kinase 1	Homo sapiens	100-103
18620489-6	2008	When stimulated with heat-killed Mycobacterium avium complex (MAC) and phorbol myristic acetate (PMA), the mononuclear cells of patients with advanced HIV-1 infection had lowered ability to produce additional interferon-gamma (either MAC or PMA) and interferon-gamma receptors (MAC).	Tetradecanoylphorbol Acetate	97-100	interferon gamma	Homo sapiens	209-225
18620489-6	2008	When stimulated with heat-killed Mycobacterium avium complex (MAC) and phorbol myristic acetate (PMA), the mononuclear cells of patients with advanced HIV-1 infection had lowered ability to produce additional interferon-gamma (either MAC or PMA) and interferon-gamma receptors (MAC).	Tetradecanoylphorbol Acetate	97-100	interferon gamma	Homo sapiens	250-266
18550569-4	2008	Epidermis hyperplasia and proliferation are increased in RKTG-deficient mice (RKTG(-/-)) after acute treatment with 7, 12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	159-195	progestin and adipoQ receptor family member III	Mus musculus	57-61
18550569-4	2008	Epidermis hyperplasia and proliferation are increased in RKTG-deficient mice (RKTG(-/-)) after acute treatment with 7, 12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	197-200	progestin and adipoQ receptor family member III	Mus musculus	57-61
18550569-5	2008	Using a two-stage DMBA/TPA carcinogenesis protocol on mouse skin, the number and size of papillomas are increased in RKTG(-/-) mice, accompanied by shortened tumor latency and enhanced keratinocyte proliferation.	Tetradecanoylphorbol Acetate	23-26	progestin and adipoQ receptor family member III	Mus musculus	117-121
18602101-3	2008	We find here that morphological activation of endothelial cells by phorbol 12-myristate 13-acetate (PMA) resulted in membrane-type 1 matrix metalloproteinase (MT1-MMP) -mediated solubilization of latent TGF-beta complexes from the ECM by proteolytic processing of LTBP-1.	Tetradecanoylphorbol Acetate	100-103	transforming growth factor beta 1	Homo sapiens	203-211
18519570-7	2008	The TPA-induced phosphorylation of MEK, extracellular signal-regulated kinase, and p90 ribosomal s6 kinase was suppressed by CPF or procyanidin B2.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase kinase 7	Homo sapiens	35-38
18477669-3	2008	In primary human nasal epithelial cells, treatment with TPA led not only to activation of phosphorylation of PKC, myristoylated alanine-rich C kinase substrate, and mitogen-activated protein kinase but also expression of novel PKC-delta, PKC-theta, and PKC-epsilon.	Tetradecanoylphorbol Acetate	56-59	proline rich transmembrane protein 2	Homo sapiens	109-112
18477669-3	2008	In primary human nasal epithelial cells, treatment with TPA led not only to activation of phosphorylation of PKC, myristoylated alanine-rich C kinase substrate, and mitogen-activated protein kinase but also expression of novel PKC-delta, PKC-theta, and PKC-epsilon.	Tetradecanoylphorbol Acetate	56-59	proline rich transmembrane protein 2	Homo sapiens	227-230
18477669-9	2008	These results suggest that TPA-induced PKC signaling enhances the barrier function of human nasal epithelial cells via transcriptional up-regulation of tight junction proteins, and the mechanisms may contribute to a drug delivery system.	Tetradecanoylphorbol Acetate	27-30	proline rich transmembrane protein 2	Homo sapiens	39-42
18534741-3	2008	The use of PMA for 15 min-activated PKCepsilon and ERK1/2, whereas incubation with PMA for 3 h induced PKCalpha activation and attenuated the PMA-triggered phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	11-14	mitogen-activated protein kinase 3	Homo sapiens	175-181
18534741-3	2008	The use of PMA for 15 min-activated PKCepsilon and ERK1/2, whereas incubation with PMA for 3 h induced PKCalpha activation and attenuated the PMA-triggered phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	83-86	protein kinase C alpha	Homo sapiens	103-111
18534741-1	2008	The aim of this investigation was to contribute to current knowledge about intracellular mechanisms that are involved in lactotroph cell proliferation, by evaluating the role of PKCalpha, PKCepsilon and extracellular-signal regulated kinase (ERK) 1/2 in response to phorbol 12-myristate13-acetate (PMA).	Tetradecanoylphorbol Acetate	266-296	mitogen-activated protein kinase 1	Homo sapiens	203-250
18534741-3	2008	The use of PMA for 15 min-activated PKCepsilon and ERK1/2, whereas incubation with PMA for 3 h induced PKCalpha activation and attenuated the PMA-triggered phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	83-86	mitogen-activated protein kinase 3	Homo sapiens	175-181
18534741-2	2008	In primary pituitary cultures, the activation of protein kinase C (PKC) by PMA for 15 min stimulated lactotroph proliferation; whereas a prolonged activation for 3-8h diminished this proliferative effect.	Tetradecanoylphorbol Acetate	75-78	protein kinase C alpha	Homo sapiens	67-70
18534741-4	2008	The following inhibitors: PKCs (bisindolylmaleimide I), PKCepsilon (epsilonV1 peptide) and ERK1/2 (PD98059) prevented the mitogenic activity induced by PMA for 15 min.	Tetradecanoylphorbol Acetate	152-155	mitogen-activated protein kinase 3	Homo sapiens	91-97
18534741-3	2008	The use of PMA for 15 min-activated PKCepsilon and ERK1/2, whereas incubation with PMA for 3 h induced PKCalpha activation and attenuated the PMA-triggered phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	11-14	mitogen-activated protein kinase 3	Homo sapiens	51-57
18606643-4	2008	IkappaB kinase (IKK) activation by direct protein kinase C (PKC) stimulation with PMA plus ionomycin (P/I) was abrogated in CARMA1-deficient NK cells, similar to T and B lymphocytes, whereas CARD9-deficient dendritic cells (DCs) exhibited normal P/I-induced IKK activation.	Tetradecanoylphorbol Acetate	82-85	caspase recruitment domain family member 11	Homo sapiens	124-130
18534633-5	2008	In the present study, to further elucidate the molecular mechanisms underlying the chemopreventive activity of hemin, its effect on the expression of ODC and cyclooxygenase (COX)-2, and the activation of nuclear factor-kappa B (NF-kappaB) and mitogen-activated protein kinases (MAPKs) regulating these proteins were explored in mouse skin with TPA-induced inflammation.	Tetradecanoylphorbol Acetate	344-347	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	204-226
18413231-7	2008	When cells are stimulated with thapsigargin and PMA, agents that increase intracellular Ca(2+) and activate PKC, respectively, PKC-dependent ERK activation is required for lytic granule exocytosis.	Tetradecanoylphorbol Acetate	48-51	proline rich transmembrane protein 2	Homo sapiens	108-111
18413231-7	2008	When cells are stimulated with thapsigargin and PMA, agents that increase intracellular Ca(2+) and activate PKC, respectively, PKC-dependent ERK activation is required for lytic granule exocytosis.	Tetradecanoylphorbol Acetate	48-51	proline rich transmembrane protein 2	Homo sapiens	127-130
18413231-7	2008	When cells are stimulated with thapsigargin and PMA, agents that increase intracellular Ca(2+) and activate PKC, respectively, PKC-dependent ERK activation is required for lytic granule exocytosis.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 1	Homo sapiens	141-144
18511036-4	2008	In the present study, we found three peculiar characteristics of porcine polymorphonuclear leukocyte that had been induced to spread over fibrinogen-coated surfaces by phorbol 12-myristate 13-acetate (PMA) in acidified medium.	Tetradecanoylphorbol Acetate	168-199	fibrinogen beta chain	Homo sapiens	138-148
18511036-4	2008	In the present study, we found three peculiar characteristics of porcine polymorphonuclear leukocyte that had been induced to spread over fibrinogen-coated surfaces by phorbol 12-myristate 13-acetate (PMA) in acidified medium.	Tetradecanoylphorbol Acetate	201-204	fibrinogen beta chain	Homo sapiens	138-148
18534633-8	2008	In addition, hemin suppressed the TPA-induced activation of extracellular signal-regulated protein kinase (ERK) and p38 MAPK in a dose-dependent manner.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 1	Mus musculus	60-105
18534633-8	2008	In addition, hemin suppressed the TPA-induced activation of extracellular signal-regulated protein kinase (ERK) and p38 MAPK in a dose-dependent manner.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 1	Mus musculus	107-110
18534633-8	2008	In addition, hemin suppressed the TPA-induced activation of extracellular signal-regulated protein kinase (ERK) and p38 MAPK in a dose-dependent manner.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 1	Mus musculus	120-124
18457657-2	2008	This study showed that stimulation with anti-CD3 mAb, PMA plus ionomycin, or an antigen increased the levels of GRP78 mRNA in primary T cells, which was inhibited by Ca(2+) chelators EGTA and BAPTA-AM and by an inhibitor of calcineurin FK506.	Tetradecanoylphorbol Acetate	54-57	heat shock protein 5	Mus musculus	112-117
18457657-4	2008	Furthermore, overexpression of GRP78 inhibited PMA/ionomycin-induced cell death in EL-4 cells.	Tetradecanoylphorbol Acetate	47-50	heat shock protein 5	Mus musculus	31-36
18541274-3	2008	Zinc significantly reduced IFN-gamma expression and activator protein-1 (AP-1) signaling in cells activated by phorbol 12-myristate 13-acetate (PMA) and phytohemagglutinin (PHA) without affecting cell viability.	Tetradecanoylphorbol Acetate	111-142	interferon gamma	Homo sapiens	27-36
18534633-9	2008	Taken together, hemin inhibited TPA-induced COX-2 expression by altering NF-kappaB signaling pathway via ERK and p38 MAPK, as well as TPA-induced ODC expression in mouse skin.	Tetradecanoylphorbol Acetate	32-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-82
18534633-7	2008	Pretreatment with hemin reduced the expression of ODC and COX-2, and also reduced NF-kappaB activation in TPA-stimulated mouse skin.	Tetradecanoylphorbol Acetate	106-109	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	82-91
18534633-9	2008	Taken together, hemin inhibited TPA-induced COX-2 expression by altering NF-kappaB signaling pathway via ERK and p38 MAPK, as well as TPA-induced ODC expression in mouse skin.	Tetradecanoylphorbol Acetate	32-35	mitogen-activated protein kinase 1	Mus musculus	105-108
18436431-3	2008	Compared with TNFalpha, PMA weakly induces NF-kappaB DNA binding and this effect was not associated with serine 32/36 phosphorylation of IkappaBalpha.	Tetradecanoylphorbol Acetate	24-27	nuclear factor kappa B subunit 1	Homo sapiens	43-52
18541274-3	2008	Zinc significantly reduced IFN-gamma expression and activator protein-1 (AP-1) signaling in cells activated by phorbol 12-myristate 13-acetate (PMA) and phytohemagglutinin (PHA) without affecting cell viability.	Tetradecanoylphorbol Acetate	144-147	interferon gamma	Homo sapiens	27-36
18491231-4	2008	At the differentiation inducing concentrations, ATO (&lt;0.5 microM), dimethyl sulfoxide, 1,25-dihydroxy-vitamin-D3, and phorbol-12-myristate 13-acetate also significantly induced DAP5/p97 expression in NB4 cells.	Tetradecanoylphorbol Acetate	121-152	eukaryotic translation initiation factor 4 gamma 2	Homo sapiens	180-184
18491231-4	2008	At the differentiation inducing concentrations, ATO (&lt;0.5 microM), dimethyl sulfoxide, 1,25-dihydroxy-vitamin-D3, and phorbol-12-myristate 13-acetate also significantly induced DAP5/p97 expression in NB4 cells.	Tetradecanoylphorbol Acetate	121-152	eukaryotic translation initiation factor 4 gamma 2	Homo sapiens	185-188
18436431-9	2008	Furthermore, combined knockdown of PKCdelta and epsilon revealed an increased inhibitory effect on PMA-stimulated NF-kappaB-dependent transcription suggesting that PMA-induced NF-kappaB-dependent transcription is driven by novel PKC isoforms, particularly PKCdelta and epsilon.	Tetradecanoylphorbol Acetate	99-102	nuclear factor kappa B subunit 1	Homo sapiens	114-123
18436431-9	2008	Furthermore, combined knockdown of PKCdelta and epsilon revealed an increased inhibitory effect on PMA-stimulated NF-kappaB-dependent transcription suggesting that PMA-induced NF-kappaB-dependent transcription is driven by novel PKC isoforms, particularly PKCdelta and epsilon.	Tetradecanoylphorbol Acetate	99-102	nuclear factor kappa B subunit 1	Homo sapiens	176-185
18436431-9	2008	Furthermore, combined knockdown of PKCdelta and epsilon revealed an increased inhibitory effect on PMA-stimulated NF-kappaB-dependent transcription suggesting that PMA-induced NF-kappaB-dependent transcription is driven by novel PKC isoforms, particularly PKCdelta and epsilon.	Tetradecanoylphorbol Acetate	164-167	nuclear factor kappa B subunit 1	Homo sapiens	114-123
18436431-9	2008	Furthermore, combined knockdown of PKCdelta and epsilon revealed an increased inhibitory effect on PMA-stimulated NF-kappaB-dependent transcription suggesting that PMA-induced NF-kappaB-dependent transcription is driven by novel PKC isoforms, particularly PKCdelta and epsilon.	Tetradecanoylphorbol Acetate	164-167	nuclear factor kappa B subunit 1	Homo sapiens	176-185
18575777-4	2008	Forced expression of Dlk1 in transfected K562 cells enhanced proliferation, affected apoptosis induced by As2O3, and also influenced cell cycle induced by 12-O-tetra decanoylphorbol-acetate (TPA).	Tetradecanoylphorbol Acetate	191-194	delta like non-canonical Notch ligand 1	Homo sapiens	21-25
18381652-5	2008	Exposure to PMA increases the ubiquitylation of GLT1 in transfected cells and in the rat brain, and this ubiquitylated GLT1 accumulates in the intracellular compartment.	Tetradecanoylphorbol Acetate	12-15	solute carrier family 1 member 2	Rattus norvegicus	48-52
18381652-5	2008	Exposure to PMA increases the ubiquitylation of GLT1 in transfected cells and in the rat brain, and this ubiquitylated GLT1 accumulates in the intracellular compartment.	Tetradecanoylphorbol Acetate	12-15	solute carrier family 1 member 2	Rattus norvegicus	119-123
18270969-0	2008	Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells.	Tetradecanoylphorbol Acetate	94-97	mitogen-activated protein kinase 3	Homo sapiens	20-26
18270969-1	2008	Extracellular signal-regulated kinase (Erk)1/2 activity signals myeloid cell differentiation induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	104-141	mitogen-activated protein kinase 3	Homo sapiens	0-46
18270969-1	2008	Extracellular signal-regulated kinase (Erk)1/2 activity signals myeloid cell differentiation induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	143-146	mitogen-activated protein kinase 3	Homo sapiens	0-46
18270969-2	2008	Previously, we reported that Erk1/2 activation (phosphorylation) induced by TPA required reactive oxygen species (ROS) as a second messenger.	Tetradecanoylphorbol Acetate	76-79	mitogen-activated protein kinase 3	Homo sapiens	29-35
18270969-3	2008	Here, we hypothesized that ROS generated in response to TPA inhibit Erk1/2-directed phosphatase activity, which leads to an increase phosphorylation of Erk1/2 to signal p21(WAF1/Cip1)-mediated growth arrest in ML-1 cells.	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase 3	Homo sapiens	68-74
18270969-3	2008	Here, we hypothesized that ROS generated in response to TPA inhibit Erk1/2-directed phosphatase activity, which leads to an increase phosphorylation of Erk1/2 to signal p21(WAF1/Cip1)-mediated growth arrest in ML-1 cells.	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase 3	Homo sapiens	152-158
18270969-3	2008	Here, we hypothesized that ROS generated in response to TPA inhibit Erk1/2-directed phosphatase activity, which leads to an increase phosphorylation of Erk1/2 to signal p21(WAF1/Cip1)-mediated growth arrest in ML-1 cells.	Tetradecanoylphorbol Acetate	56-59	cyclin dependent kinase inhibitor 1A	Homo sapiens	169-172
18270969-3	2008	Here, we hypothesized that ROS generated in response to TPA inhibit Erk1/2-directed phosphatase activity, which leads to an increase phosphorylation of Erk1/2 to signal p21(WAF1/Cip1)-mediated growth arrest in ML-1 cells.	Tetradecanoylphorbol Acetate	56-59	cyclin dependent kinase inhibitor 1A	Homo sapiens	173-177
18270969-3	2008	Here, we hypothesized that ROS generated in response to TPA inhibit Erk1/2-directed phosphatase activity, which leads to an increase phosphorylation of Erk1/2 to signal p21(WAF1/Cip1)-mediated growth arrest in ML-1 cells.	Tetradecanoylphorbol Acetate	56-59	cyclin dependent kinase inhibitor 1A	Homo sapiens	178-182
18270969-4	2008	Incubation of ML-1 cells with TPA resulted in a marked accumulation of phosphorylated Erk1/2, and is subsequent to H2O2 generation.	Tetradecanoylphorbol Acetate	30-33	mitogen-activated protein kinase 3	Homo sapiens	86-92
18270969-5	2008	Interestingly, post-TPA-treatment with N-acetylcysteine (NAC) stimulated a marked and a rapid dephosphorylation of Erk1/2, suggesting a regeneration of Erk1/2-directed phospahatase activity by NAC.	Tetradecanoylphorbol Acetate	20-23	mitogen-activated protein kinase 3	Homo sapiens	115-121
18270969-5	2008	Interestingly, post-TPA-treatment with N-acetylcysteine (NAC) stimulated a marked and a rapid dephosphorylation of Erk1/2, suggesting a regeneration of Erk1/2-directed phospahatase activity by NAC.	Tetradecanoylphorbol Acetate	20-23	mitogen-activated protein kinase 3	Homo sapiens	152-158
18270969-8	2008	Together, this study suggested that TPA stimulated ROS generation as a second messenger to activate Erk1/2 via a redox-mediated inhibition of Erk1/2-directed phosphatase in ML-1 cells.	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase 3	Homo sapiens	100-106
18270969-8	2008	Together, this study suggested that TPA stimulated ROS generation as a second messenger to activate Erk1/2 via a redox-mediated inhibition of Erk1/2-directed phosphatase in ML-1 cells.	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase 3	Homo sapiens	142-148
18425496-5	2008	There are conflicting reports regarding the effect of TPA and PKC on NF-kappaB.	Tetradecanoylphorbol Acetate	54-57	nuclear factor kappa B subunit 1	Homo sapiens	69-78
18425496-7	2008	We found that TPA promoted NF-kappaB nuclear translocation and the DNA binding of p65 dimers through PKC activation.	Tetradecanoylphorbol Acetate	14-17	nuclear factor kappa B subunit 1	Homo sapiens	27-36
18425496-9	2008	Notably, however, both TPA and the ectopic PKC displayed strong synergistic enhancement of the Tax-induced activation of the NF-kappaB transcriptional function.	Tetradecanoylphorbol Acetate	23-26	nuclear factor kappa B subunit 1	Homo sapiens	125-134
18425496-10	2008	In contrast, TPA and the ectopic PKC only slightly elevated the low activation of the NF-kappaB transcriptional capacity by cytoplasmic Tax mutants, indicating that the nuclear translocation of Tax was essential for this synergism.	Tetradecanoylphorbol Acetate	13-16	nuclear factor kappa B subunit 1	Homo sapiens	86-95
18425496-11	2008	Subsequent experiments suggested that TPA contributed to this synergism by increasing the pool of free p65 which Tax could link to CBP and elevate, thereby, the amount of a p65-Tax-CBP ternary complex that could bind to NF-kappaB-responsive promoters and stimulate their expression.	Tetradecanoylphorbol Acetate	38-41	CREB binding protein	Homo sapiens	131-134
18425496-11	2008	Subsequent experiments suggested that TPA contributed to this synergism by increasing the pool of free p65 which Tax could link to CBP and elevate, thereby, the amount of a p65-Tax-CBP ternary complex that could bind to NF-kappaB-responsive promoters and stimulate their expression.	Tetradecanoylphorbol Acetate	38-41	CREB binding protein	Homo sapiens	181-184
18425496-11	2008	Subsequent experiments suggested that TPA contributed to this synergism by increasing the pool of free p65 which Tax could link to CBP and elevate, thereby, the amount of a p65-Tax-CBP ternary complex that could bind to NF-kappaB-responsive promoters and stimulate their expression.	Tetradecanoylphorbol Acetate	38-41	nuclear factor kappa B subunit 1	Homo sapiens	220-229
18331597-8	2008	In conclusion, SAK reduces tPA/uPA-mediated Plg activation by means of SAK.Plg complex formation, consequently downregulating tPA/uPA-induced fibrinolysis.	Tetradecanoylphorbol Acetate	27-30	plasminogen activator, urokinase	Homo sapiens	31-34
18331597-8	2008	In conclusion, SAK reduces tPA/uPA-mediated Plg activation by means of SAK.Plg complex formation, consequently downregulating tPA/uPA-induced fibrinolysis.	Tetradecanoylphorbol Acetate	27-30	plasminogen activator, urokinase	Homo sapiens	130-133
18331597-8	2008	In conclusion, SAK reduces tPA/uPA-mediated Plg activation by means of SAK.Plg complex formation, consequently downregulating tPA/uPA-induced fibrinolysis.	Tetradecanoylphorbol Acetate	126-129	plasminogen activator, urokinase	Homo sapiens	31-34
18331597-8	2008	In conclusion, SAK reduces tPA/uPA-mediated Plg activation by means of SAK.Plg complex formation, consequently downregulating tPA/uPA-induced fibrinolysis.	Tetradecanoylphorbol Acetate	126-129	plasminogen activator, urokinase	Homo sapiens	130-133
18645411-5	2008	AVP also activated extracellular signal-regulated kinase 1/2 (erk1/2), a response mimicked by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but abolished by depleting cellular PKC through chronic PMA incubation.	Tetradecanoylphorbol Acetate	128-159	arginine vasopressin	Rattus norvegicus	0-3
18645411-5	2008	AVP also activated extracellular signal-regulated kinase 1/2 (erk1/2), a response mimicked by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but abolished by depleting cellular PKC through chronic PMA incubation.	Tetradecanoylphorbol Acetate	161-164	arginine vasopressin	Rattus norvegicus	0-3
18239612-4	2008	Western blotting analysis revealed that treatment with phorbol 12-myristate-13-acetate (PMA) or 4-aminophenylmercuric acetate (APMA) induced s-KIT production in cultured human melanocytes.	Tetradecanoylphorbol Acetate	55-86	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	143-146
18239612-4	2008	Western blotting analysis revealed that treatment with phorbol 12-myristate-13-acetate (PMA) or 4-aminophenylmercuric acetate (APMA) induced s-KIT production in cultured human melanocytes.	Tetradecanoylphorbol Acetate	88-91	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	143-146
18575777-6	2008	It also inhibited p38 phosphorylation in transfected K562 cells treated with TPA.	Tetradecanoylphorbol Acetate	77-80	mitogen-activated protein kinase 14	Homo sapiens	18-21
18177935-7	2008	In addition, the NF-kappaB inhibitors (pyrrolidinedithiocarbamate, BAY-11-7082 and lactacystin) suppress the TPA-induced MMP-9 enzyme activity.	Tetradecanoylphorbol Acetate	109-112	nuclear factor kappa B subunit 1	Homo sapiens	17-26
18177935-10	2008	Therefore, we suggest that ODC inhibits the TNF-alpha-elevated MMP-9 activation via NF-kappaB as TPA-induced macrophage-like differentiation and this interrupting mechanism may provide a new conceivable resolution why leukemia is poorly differentiated besides atypical growth.	Tetradecanoylphorbol Acetate	97-100	tumor necrosis factor	Homo sapiens	44-53
18177935-10	2008	Therefore, we suggest that ODC inhibits the TNF-alpha-elevated MMP-9 activation via NF-kappaB as TPA-induced macrophage-like differentiation and this interrupting mechanism may provide a new conceivable resolution why leukemia is poorly differentiated besides atypical growth.	Tetradecanoylphorbol Acetate	97-100	nuclear factor kappa B subunit 1	Homo sapiens	84-93
18435914-5	2008	Using pharmacologic and genetic tools, we demonstrate a prominent role for ERK1/2, but not JNK1/2 and p38, signaling in the TPA-induced activation of specific transcription factors that bind to the AP1 site and the SRE.	Tetradecanoylphorbol Acetate	124-127	mitogen-activated protein kinase 3	Homo sapiens	75-81
18353537-5	2008	The applied diesel particulate matter (SRM(1975)) altered the tumor initiating potency of DBP: a statistically significant decrease in overall tumor and carcinoma burden was observed following 25 weeks of promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA), compared with DBP exposure alone.	Tetradecanoylphorbol Acetate	220-256	D site albumin promoter binding protein	Mus musculus	90-93
18353537-5	2008	The applied diesel particulate matter (SRM(1975)) altered the tumor initiating potency of DBP: a statistically significant decrease in overall tumor and carcinoma burden was observed following 25 weeks of promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA), compared with DBP exposure alone.	Tetradecanoylphorbol Acetate	258-261	D site albumin promoter binding protein	Mus musculus	90-93
18560723-9	2008	AVP induced an activation of ERK1/2, which could be mimicked by the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA, 30 nmol/L, 5 min), but abolished by depletion of PKC via chronic PMA incubation (2.5 mumol/L, 24 h).	Tetradecanoylphorbol Acetate	102-133	arginine vasopressin	Rattus norvegicus	0-3
18485547-5	2008	The tPA-L1R construct produced a more robust neutralizing antibody response in vaccinated mice when the DNA vaccine was administered by gene-gun as a prime/single boost.	Tetradecanoylphorbol Acetate	4-7	IMV membrane protein	Vaccinia virus	8-11
18485547-6	2008	When the tPA-L1R construct was substituted for the unmodified L1R gene in the 4pox vaccine, given as a prime and single boost, animals were better protected from lethal challenge with vaccinia virus (VACV).	Tetradecanoylphorbol Acetate	9-12	IMV membrane protein	Vaccinia virus	13-16
18485547-7	2008	These findings indicate that adding a tPA-leader sequence can enhance the immunogenicity of the L1R gene when given as a DNA vaccine.	Tetradecanoylphorbol Acetate	38-41	IMV membrane protein	Vaccinia virus	96-99
18560723-9	2008	AVP induced an activation of ERK1/2, which could be mimicked by the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA, 30 nmol/L, 5 min), but abolished by depletion of PKC via chronic PMA incubation (2.5 mumol/L, 24 h).	Tetradecanoylphorbol Acetate	135-138	arginine vasopressin	Rattus norvegicus	0-3
18575575-7	2008	THP-1 cells were magnetically labeled with FePro, differentiated with 100 nM of phorbol ester, 12-Myristate-13-acetate (TPA) and stimulated with 100 ng/ml of LPS.	Tetradecanoylphorbol Acetate	120-123	GLI family zinc finger 2	Homo sapiens	0-5
18559098-5	2008	MC required approximately 4 h of stimulation with Ag (DNP-albumin, following preincubation with IgE anti-DNP), ionomycin, or PMA to enable a strong chemotactic response towards C5a, paralleled by a distinct C5aR upregulation.	Tetradecanoylphorbol Acetate	125-128	hemolytic complement	Mus musculus	177-180
18430969-6	2008	Treatment with selective PKC inhibitors prevented this PMA effect and suggested that a conventional PKC was the priming kinase.	Tetradecanoylphorbol Acetate	55-58	protein kinase C, alpha	Mus musculus	25-28
18397889-3	2008	Here, we use RNA interference to reduce p53 expression in CHRF cells and show that reduced p53 activity leads to a greater fraction of polyploid cells, higher mean and maximum ploidy, accelerated DNA synthesis, and delayed apoptosis and cell death upon phorbol 12-myristate 13-acetate-induced Mk differentiation.	Tetradecanoylphorbol Acetate	253-284	tumor protein p53	Homo sapiens	91-94
18430969-6	2008	Treatment with selective PKC inhibitors prevented this PMA effect and suggested that a conventional PKC was the priming kinase.	Tetradecanoylphorbol Acetate	55-58	protein kinase C, alpha	Mus musculus	100-103
18195054-7	2008	In addition, xanthine 70 (10 muM) inhibited 12-O-tetradecanoylphorbol-13-acetate- or H-Ras-induced neoplastic transformation in JB6 P+ cells by 78.2 or 62.0%, respectively.	Tetradecanoylphorbol Acetate	44-80	latexin	Homo sapiens	29-32
18356551-7	2008	Moreover, FVB.LDLR-/- macrophages showed 5-fold increased PMA-induced shedding of tumor necrosis factor (TNF)-alpha and 32% increased release of TNF-receptor I compared to B6.LDLR-/-.	Tetradecanoylphorbol Acetate	58-61	tumor necrosis factor	Mus musculus	82-115
18372343-4	2008	The present studies revealed that protein kinase C (PKC) alpha/ERK signaling is important for the activation of LHR promoter activity, and the increase of endogenous transcripts induced by phorbol-12-myristate-13-acetate (PMA) in HeLa cells.	Tetradecanoylphorbol Acetate	222-225	mitogen-activated protein kinase 1	Homo sapiens	63-66
18295514-1	2008	Phorbol-12-myristate-13-acetate (PMA) significantly elevated c-mpl promoter activity and the protein kinase C (PKC) inhibitors GF 109203, H7 and calphostin C conspicuously reduced the steady level of the activity.	Tetradecanoylphorbol Acetate	0-31	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	61-66
18295514-1	2008	Phorbol-12-myristate-13-acetate (PMA) significantly elevated c-mpl promoter activity and the protein kinase C (PKC) inhibitors GF 109203, H7 and calphostin C conspicuously reduced the steady level of the activity.	Tetradecanoylphorbol Acetate	33-36	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	61-66
18309089-5	2008	The direct Ca2+- and phospholipid-dependent protein kinase (PKC) activator phorbol-12-myristate-13-acetate stimulated ERK1/2 phosphorylation and decreased EGFR binding at both 15 min and 18 h. Furthermore, inhibitors of PKC partially inhibited ERK1/2 phosphorylation and the 15-min decrease but completely inhibited the 18-h decrease.	Tetradecanoylphorbol Acetate	75-106	mitogen-activated protein kinase 3	Homo sapiens	118-124
18309089-5	2008	The direct Ca2+- and phospholipid-dependent protein kinase (PKC) activator phorbol-12-myristate-13-acetate stimulated ERK1/2 phosphorylation and decreased EGFR binding at both 15 min and 18 h. Furthermore, inhibitors of PKC partially inhibited ERK1/2 phosphorylation and the 15-min decrease but completely inhibited the 18-h decrease.	Tetradecanoylphorbol Acetate	75-106	epidermal growth factor receptor	Homo sapiens	155-159
18309089-5	2008	The direct Ca2+- and phospholipid-dependent protein kinase (PKC) activator phorbol-12-myristate-13-acetate stimulated ERK1/2 phosphorylation and decreased EGFR binding at both 15 min and 18 h. Furthermore, inhibitors of PKC partially inhibited ERK1/2 phosphorylation and the 15-min decrease but completely inhibited the 18-h decrease.	Tetradecanoylphorbol Acetate	75-106	mitogen-activated protein kinase 3	Homo sapiens	244-250
18400024-6	2008	Most PBP fractions decreased TPA-induced cell proliferation by decreasing activation of signalling kinases (c-Jun N-terminal protein kinase, extracellular signal-regulated protein kinase, p38 protein kinase and Akt), transcription factors (activator protein-1 and nuclear factor kappa B) and inflammatory protein (cyclooxygenase 2).	Tetradecanoylphorbol Acetate	29-32	thymoma viral proto-oncogene 1	Mus musculus	211-214
18372343-4	2008	The present studies revealed that protein kinase C (PKC) alpha/ERK signaling is important for the activation of LHR promoter activity, and the increase of endogenous transcripts induced by phorbol-12-myristate-13-acetate (PMA) in HeLa cells.	Tetradecanoylphorbol Acetate	189-220	protein kinase C alpha	Homo sapiens	34-62
18372343-4	2008	The present studies revealed that protein kinase C (PKC) alpha/ERK signaling is important for the activation of LHR promoter activity, and the increase of endogenous transcripts induced by phorbol-12-myristate-13-acetate (PMA) in HeLa cells.	Tetradecanoylphorbol Acetate	189-220	mitogen-activated protein kinase 1	Homo sapiens	63-66
18372343-4	2008	The present studies revealed that protein kinase C (PKC) alpha/ERK signaling is important for the activation of LHR promoter activity, and the increase of endogenous transcripts induced by phorbol-12-myristate-13-acetate (PMA) in HeLa cells.	Tetradecanoylphorbol Acetate	222-225	protein kinase C alpha	Homo sapiens	34-62
18507834-8	2008	The production of IL-2 in peripheral blood mononuclear cell cultures was induced by activation for 48 hr with Staphylococcal protein A (SPA) and, in parallel preparations, with the combination of phorbol ester (TPA) and calcium ionophore.	Tetradecanoylphorbol Acetate	211-214	interleukin 2	Homo sapiens	18-22
19031740-7	2008	Western blot was used to detect the ERK1/2 signal pathway after the stimulation of phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	83-114	mitogen-activated protein kinase 3	Homo sapiens	36-42
18463134-5	2008	In contrast to the inhibition of transcription by JDP2, JDP2-CHOP complex strongly enhances transcription from promoters containing TPA response elements (TRE), but not from those containing cyclic AMP response elements (CRE).	Tetradecanoylphorbol Acetate	132-135	DNA damage inducible transcript 3	Homo sapiens	61-65
18507834-12	2008	Conversely, IL-2 synthesis induced by TPA and calcium ionophore was unaltered by either type of SMT and was comparable to that in VC group at all time points.	Tetradecanoylphorbol Acetate	38-41	interleukin 2	Homo sapiens	12-16
18420182-11	2008	Our results implicate PKC alpha in the potentiation of Ca v 2.3 currents by MCh and PKC betaII and epsilon in the potentiation of Ca v 2.3 currents by PMA.	Tetradecanoylphorbol Acetate	151-154	protein kinase C, alpha L homeolog	Xenopus laevis	22-31
18241981-0	2008	Immunotherapy prolongs the serum CEA-TPA-CA15.3 lead time at the metastatic progression in endocrine-dependent breast cancer patients: a retrospective longitudinal study.	Tetradecanoylphorbol Acetate	37-40	CEA cell adhesion molecule 3	Homo sapiens	33-36
18461199-1	2008	Density functional calculations have been carried out on the experimentally characterized Co(III) [Co(N4)(O2CO)]+ carbonate complexes containing a tripodal tetraamine ligand (N4 = tpa, Metpa, Me2tpa, Me3tpa, pmea, pmap, tepa) and also the model [Co(NH3)4(O2CO)]+ system.	Tetradecanoylphorbol Acetate	180-183	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	90-97
18483250-7	2008	In addition, reduced activation of both Akt and the mammalian target of rapamycin (mTOR) was observed in LID mice following TPA treatment relative to wild-type controls.	Tetradecanoylphorbol Acetate	124-127	AKT serine/threonine kinase 1	Homo sapiens	40-43
18483250-7	2008	In addition, reduced activation of both Akt and the mammalian target of rapamycin (mTOR) was observed in LID mice following TPA treatment relative to wild-type controls.	Tetradecanoylphorbol Acetate	124-127	mechanistic target of rapamycin kinase	Homo sapiens	52-81
18483250-7	2008	In addition, reduced activation of both Akt and the mammalian target of rapamycin (mTOR) was observed in LID mice following TPA treatment relative to wild-type controls.	Tetradecanoylphorbol Acetate	124-127	mechanistic target of rapamycin kinase	Homo sapiens	83-87
18241981-5	2008	At disease progression, CEA-TPA-CA15.3 sensitivity was 92.5% in the group b (studied patients) and 88.5% in the group c (controls).	Tetradecanoylphorbol Acetate	28-31	CEA cell adhesion molecule 3	Homo sapiens	24-27
18241981-8	2008	The CEA-TPA-CA15.3 tumour marker panel accurately predicted metastatic disease progression and immunotherapy significantly prolonged the CEA-TPA-CA15.3 lead time.	Tetradecanoylphorbol Acetate	8-11	CEA cell adhesion molecule 3	Homo sapiens	4-7
18241981-8	2008	The CEA-TPA-CA15.3 tumour marker panel accurately predicted metastatic disease progression and immunotherapy significantly prolonged the CEA-TPA-CA15.3 lead time.	Tetradecanoylphorbol Acetate	141-144	CEA cell adhesion molecule 3	Homo sapiens	4-7
18241981-8	2008	The CEA-TPA-CA15.3 tumour marker panel accurately predicted metastatic disease progression and immunotherapy significantly prolonged the CEA-TPA-CA15.3 lead time.	Tetradecanoylphorbol Acetate	141-144	CEA cell adhesion molecule 3	Homo sapiens	137-140
18423386-5	2008	Analysis of the Ras-MAPK pathway upon phorbol myristate acetate (PMA) and ionomycin stimulation revealed that PLD2 promoted an early and sustained increase in ERK1/2 phosphorylation in both cell lines.	Tetradecanoylphorbol Acetate	38-63	mitogen-activated protein kinase 3	Homo sapiens	20-24
18339327-5	2008	Neu3 overexpression inhibited the PMA-induced ERK1/2 and p38 MAPK phosphorylation in the K562 cells.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 3	Homo sapiens	46-52
18339327-5	2008	Neu3 overexpression inhibited the PMA-induced ERK1/2 and p38 MAPK phosphorylation in the K562 cells.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 1	Homo sapiens	57-60
18339327-5	2008	Neu3 overexpression inhibited the PMA-induced ERK1/2 and p38 MAPK phosphorylation in the K562 cells.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 3	Homo sapiens	61-65
18423386-5	2008	Analysis of the Ras-MAPK pathway upon phorbol myristate acetate (PMA) and ionomycin stimulation revealed that PLD2 promoted an early and sustained increase in ERK1/2 phosphorylation in both cell lines.	Tetradecanoylphorbol Acetate	65-68	mitogen-activated protein kinase 3	Homo sapiens	20-24
18056764-6	2008	Phorbol-12-myristate-13-acetate (PMA) enhanced the ability of HUVEC to organize into tubular networks when plated on Matrigel, a phenomenon that could be prevented by PKC inhibitors.	Tetradecanoylphorbol Acetate	0-31	protein kinase C alpha	Homo sapiens	167-170
18056764-6	2008	Phorbol-12-myristate-13-acetate (PMA) enhanced the ability of HUVEC to organize into tubular networks when plated on Matrigel, a phenomenon that could be prevented by PKC inhibitors.	Tetradecanoylphorbol Acetate	33-36	protein kinase C alpha	Homo sapiens	167-170
18056764-9	2008	PMA-induced tube formation was reduced by inhibition of the VEGF receptor kinase, or by VEGF knockdown.	Tetradecanoylphorbol Acetate	0-3	vascular endothelial growth factor A	Homo sapiens	60-64
18056764-9	2008	PMA-induced tube formation was reduced by inhibition of the VEGF receptor kinase, or by VEGF knockdown.	Tetradecanoylphorbol Acetate	0-3	vascular endothelial growth factor A	Homo sapiens	88-92
18245203-4	2008	Angiotensin(1-7) increased the protein kinase C (PKC) activity similarly to phorbol-12-myristate-13-acetate (PMA), an activator of PKC.	Tetradecanoylphorbol Acetate	76-107	PKC	Sus scrofa	131-134
18325031-2	2008	In this study, we aimed to investigate the effect of montelukast on nuclear factor (NF)-kappaB-associated histone acetylation activity in phorbol myristate acetate (PMA)-differentiated U937 cells.	Tetradecanoylphorbol Acetate	138-163	nuclear factor kappa B subunit 1	Homo sapiens	68-94
18325031-2	2008	In this study, we aimed to investigate the effect of montelukast on nuclear factor (NF)-kappaB-associated histone acetylation activity in phorbol myristate acetate (PMA)-differentiated U937 cells.	Tetradecanoylphorbol Acetate	165-168	nuclear factor kappa B subunit 1	Homo sapiens	68-94
18245203-4	2008	Angiotensin(1-7) increased the protein kinase C (PKC) activity similarly to phorbol-12-myristate-13-acetate (PMA), an activator of PKC.	Tetradecanoylphorbol Acetate	109-112	PKC	Sus scrofa	131-134
18435438-3	2008	Phorbol-12-myristic-13-acetate (PMA)-treated THP-1 monocytes differentiated into macrophages and synthesized lipoprotein lipase (LPL), the major enzyme for hydrolysis of triglycerides.	Tetradecanoylphorbol Acetate	32-35	GLI family zinc finger 2	Homo sapiens	45-50
18425353-6	2008	Culture with PMA (10(-6) M) for 24 or 48 h caused a remarkable increase in nuclear regucalcin protein levels.	Tetradecanoylphorbol Acetate	13-16	regucalcin	Rattus norvegicus	83-93
18183498-2	2008	Real time RT/PCR and Western blot analysis demonstrated that Snail mRNA and protein, respectively, were induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	115-151	snail family transcriptional repressor 1	Homo sapiens	61-66
18183498-2	2008	Real time RT/PCR and Western blot analysis demonstrated that Snail mRNA and protein, respectively, were induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	153-156	snail family transcriptional repressor 1	Homo sapiens	61-66
18183498-3	2008	Blockade of gene expression of Snail by antisense oligodeoxynucleotide and/or siRNA technique can prevent not only the TPA-triggered EMT/cell migration and growth inhibition of HepG2 but also TPA-induced down-regulation of E-cadherin and up-regulation of p15(INK4b).	Tetradecanoylphorbol Acetate	119-122	snail family transcriptional repressor 1	Homo sapiens	31-36
18183498-3	2008	Blockade of gene expression of Snail by antisense oligodeoxynucleotide and/or siRNA technique can prevent not only the TPA-triggered EMT/cell migration and growth inhibition of HepG2 but also TPA-induced down-regulation of E-cadherin and up-regulation of p15(INK4b).	Tetradecanoylphorbol Acetate	119-122	cadherin 1	Homo sapiens	223-233
18183498-3	2008	Blockade of gene expression of Snail by antisense oligodeoxynucleotide and/or siRNA technique can prevent not only the TPA-triggered EMT/cell migration and growth inhibition of HepG2 but also TPA-induced down-regulation of E-cadherin and up-regulation of p15(INK4b).	Tetradecanoylphorbol Acetate	119-122	cyclin dependent kinase inhibitor 2B	Homo sapiens	255-258
18183498-3	2008	Blockade of gene expression of Snail by antisense oligodeoxynucleotide and/or siRNA technique can prevent not only the TPA-triggered EMT/cell migration and growth inhibition of HepG2 but also TPA-induced down-regulation of E-cadherin and up-regulation of p15(INK4b).	Tetradecanoylphorbol Acetate	119-122	cyclin dependent kinase inhibitor 2B	Homo sapiens	259-264
18183498-3	2008	Blockade of gene expression of Snail by antisense oligodeoxynucleotide and/or siRNA technique can prevent not only the TPA-triggered EMT/cell migration and growth inhibition of HepG2 but also TPA-induced down-regulation of E-cadherin and up-regulation of p15(INK4b).	Tetradecanoylphorbol Acetate	192-195	snail family transcriptional repressor 1	Homo sapiens	31-36
18183498-3	2008	Blockade of gene expression of Snail by antisense oligodeoxynucleotide and/or siRNA technique can prevent not only the TPA-triggered EMT/cell migration and growth inhibition of HepG2 but also TPA-induced down-regulation of E-cadherin and up-regulation of p15(INK4b).	Tetradecanoylphorbol Acetate	192-195	cadherin 1	Homo sapiens	223-233
18183498-3	2008	Blockade of gene expression of Snail by antisense oligodeoxynucleotide and/or siRNA technique can prevent not only the TPA-triggered EMT/cell migration and growth inhibition of HepG2 but also TPA-induced down-regulation of E-cadherin and up-regulation of p15(INK4b).	Tetradecanoylphorbol Acetate	192-195	cyclin dependent kinase inhibitor 2B	Homo sapiens	255-258
18183498-3	2008	Blockade of gene expression of Snail by antisense oligodeoxynucleotide and/or siRNA technique can prevent not only the TPA-triggered EMT/cell migration and growth inhibition of HepG2 but also TPA-induced down-regulation of E-cadherin and up-regulation of p15(INK4b).	Tetradecanoylphorbol Acetate	192-195	cyclin dependent kinase inhibitor 2B	Homo sapiens	259-264
18183498-4	2008	Moreover, the TPA-triggered promoter activation of p15(INK4b) was also prevented.	Tetradecanoylphorbol Acetate	14-17	cyclin dependent kinase inhibitor 2B	Homo sapiens	51-54
18183498-4	2008	Moreover, the TPA-triggered promoter activation of p15(INK4b) was also prevented.	Tetradecanoylphorbol Acetate	14-17	cyclin dependent kinase inhibitor 2B	Homo sapiens	55-60
18594782-3	2008	RESULTS: Activation of endothelial protein kinase C (PKC) by either phorbol myristate acetate (PMA) or bryostatin-1 (a potent PKC delta and epsilon activator) completely abolished neutrophil migration mediated by either endothelial TNF-alpha stimulation or LTB4.	Tetradecanoylphorbol Acetate	68-93	protein kinase C alpha	Homo sapiens	53-56
18594782-3	2008	RESULTS: Activation of endothelial protein kinase C (PKC) by either phorbol myristate acetate (PMA) or bryostatin-1 (a potent PKC delta and epsilon activator) completely abolished neutrophil migration mediated by either endothelial TNF-alpha stimulation or LTB4.	Tetradecanoylphorbol Acetate	68-93	tumor necrosis factor	Homo sapiens	232-241
18594782-3	2008	RESULTS: Activation of endothelial protein kinase C (PKC) by either phorbol myristate acetate (PMA) or bryostatin-1 (a potent PKC delta and epsilon activator) completely abolished neutrophil migration mediated by either endothelial TNF-alpha stimulation or LTB4.	Tetradecanoylphorbol Acetate	95-98	protein kinase C alpha	Homo sapiens	53-56
18325701-7	2008	RESULTS: HcFs inhibited the expression of IL-4 and IL-5 in response to phorbol 12-myristate 13-acetate (PMA) and calcium ionophore (CaI) in Jurkat T cells and the human mast cell line, HMC-1.	Tetradecanoylphorbol Acetate	71-102	interleukin 4	Homo sapiens	42-46
18325701-7	2008	RESULTS: HcFs inhibited the expression of IL-4 and IL-5 in response to phorbol 12-myristate 13-acetate (PMA) and calcium ionophore (CaI) in Jurkat T cells and the human mast cell line, HMC-1.	Tetradecanoylphorbol Acetate	104-107	interleukin 4	Homo sapiens	42-46
18291120-3	2008	Treatment of human umbilical vein endothelial cells (HUVEC) and HUVEC-derived EA.hy 926 endothelial cells with phorbol 12-myristate 13-acetate (PMA) or phorbol 12,13-dibutyrate led to a PKC-dependent biphasic expression of the gp91phox homolog Nox4.	Tetradecanoylphorbol Acetate	111-142	protein kinase C alpha	Homo sapiens	186-189
18358838-3	2008	Our results demonstrated that CsA and BA blocked TPA-induced p53 translocation, leading to protection against the loss of mitochondrial membrane potential and Complex I activity, and eventually suppression of apoptosis.	Tetradecanoylphorbol Acetate	49-52	tumor protein p53	Homo sapiens	61-64
18096663-8	2008	The PTX-insensitive step in agonist-induced inhibition of PRL release was not affected by the addition of wortmannin, an inhibitor of phosphatidylinositol 3-kinase, and lithium, an inhibitor of glycogen synthase kinase-3, but was attenuated in the presence of phorbol 12-myristate 13-acetate, which inhibits G(z) signaling pathway in a protein kinase C-dependent manner.	Tetradecanoylphorbol Acetate	260-291	prolactin	Homo sapiens	58-61
18261985-2	2008	In the VEGF family, both mRNA and protein expression of VEGF-C were up-regulated in phorbol myristate acetate (PMA)-differentiated HL-60 cells.	Tetradecanoylphorbol Acetate	84-109	vascular endothelial growth factor A	Homo sapiens	7-11
18261985-2	2008	In the VEGF family, both mRNA and protein expression of VEGF-C were up-regulated in phorbol myristate acetate (PMA)-differentiated HL-60 cells.	Tetradecanoylphorbol Acetate	84-109	vascular endothelial growth factor C	Homo sapiens	56-62
18261985-2	2008	In the VEGF family, both mRNA and protein expression of VEGF-C were up-regulated in phorbol myristate acetate (PMA)-differentiated HL-60 cells.	Tetradecanoylphorbol Acetate	111-114	vascular endothelial growth factor A	Homo sapiens	7-11
18261985-2	2008	In the VEGF family, both mRNA and protein expression of VEGF-C were up-regulated in phorbol myristate acetate (PMA)-differentiated HL-60 cells.	Tetradecanoylphorbol Acetate	111-114	vascular endothelial growth factor C	Homo sapiens	56-62
18199827-5	2008	NFkappaB transcriptional targets macrophage inflammatory protein-2 (MIP-2/CXCL2/3), keratinocyte chemokine (KC/CXCL1), and tumor necrosis factor [alfa] (TNFalpha) were constitutively up-regulated and further increased after TPA challenge both in cultured keratinocytes and in transgenic mice.	Tetradecanoylphorbol Acetate	224-227	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-8
18427282-3	2008	Atorvastatin from 2 microM to 40 microM dose-dependently inhibited ABCA1 expression in human monocyte-derived macrophages and phorbol 12-myristate 13-acetate (PMA)-stimulated THP-1 monocytes.	Tetradecanoylphorbol Acetate	126-157	GLI family zinc finger 2	Homo sapiens	175-180
18174193-4	2008	Here, we challenged the skin of CCHCR1 transgenic mice with wounding or 12-O-tetradecanoyl-13-acetate (TPA), treatments able to induce epidermal hyperplasia and proliferation that both are hallmarks of psoriasis.	Tetradecanoylphorbol Acetate	103-106	coiled-coil alpha-helical rod protein 1	Mus musculus	32-38
18174193-6	2008	Early wound healing on days 1 and 4 was delayed, and TPA-induced epidermal hyperproliferation was less pronounced in mice with the CCHCR1*WWCC risk allele than in mice with the normal allele or in wild-type animals.	Tetradecanoylphorbol Acetate	53-56	coiled-coil alpha-helical rod protein 1	Mus musculus	131-137
18427282-3	2008	Atorvastatin from 2 microM to 40 microM dose-dependently inhibited ABCA1 expression in human monocyte-derived macrophages and phorbol 12-myristate 13-acetate (PMA)-stimulated THP-1 monocytes.	Tetradecanoylphorbol Acetate	159-162	GLI family zinc finger 2	Homo sapiens	175-180
18174358-7	2008	However, phorbol 12-myristate 13-acetate-induced inflammation was only partially inhibited by GR-TR, which efficiently repressed IL-1beta and MMP-3 genes while weakly repressing IL-6 and TNF-alpha.	Tetradecanoylphorbol Acetate	9-40	interleukin 1 beta	Mus musculus	129-137
18174358-7	2008	However, phorbol 12-myristate 13-acetate-induced inflammation was only partially inhibited by GR-TR, which efficiently repressed IL-1beta and MMP-3 genes while weakly repressing IL-6 and TNF-alpha.	Tetradecanoylphorbol Acetate	9-40	interleukin 6	Mus musculus	178-182
18174358-7	2008	However, phorbol 12-myristate 13-acetate-induced inflammation was only partially inhibited by GR-TR, which efficiently repressed IL-1beta and MMP-3 genes while weakly repressing IL-6 and TNF-alpha.	Tetradecanoylphorbol Acetate	9-40	tumor necrosis factor	Mus musculus	187-196
18178962-6	2008	In a transient luciferase assay, AKIP1 cotransfection efficiently increased the transcriptional activity of NF-kappaB induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	129-160	A-kinase interacting protein 1	Homo sapiens	33-38
18211802-5	2008	Stimulation of HeLa S3 cells with 12-O-tetradecanoyl-phorbol-13-acetate induced the phosphorylation of GEF-H1 in an ERK-dependent manner.	Tetradecanoylphorbol Acetate	34-71	mitogen-activated protein kinase 1	Homo sapiens	116-119
18178962-6	2008	In a transient luciferase assay, AKIP1 cotransfection efficiently increased the transcriptional activity of NF-kappaB induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	129-160	nuclear factor kappa B subunit 1	Homo sapiens	108-117
18178962-6	2008	In a transient luciferase assay, AKIP1 cotransfection efficiently increased the transcriptional activity of NF-kappaB induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	162-165	A-kinase interacting protein 1	Homo sapiens	33-38
18178962-6	2008	In a transient luciferase assay, AKIP1 cotransfection efficiently increased the transcriptional activity of NF-kappaB induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	162-165	nuclear factor kappa B subunit 1	Homo sapiens	108-117
18178962-8	2008	We found that PKAc, which is maintained in an inactive form by binding to IkappaBalpha and NF-kappaB in resting cells, was activated by PMA-induced signaling and could phosphorylate p65.	Tetradecanoylphorbol Acetate	136-139	nuclear factor kappa B subunit 1	Homo sapiens	91-100
18282472-4	2008	However, caspase-9/-3-mediated cytotoxicity can be induced in TPA-differentiated cells if they are pretreated with a protein kinase C (PKC) or a mitogen activated protein kinase (MEK) inhibitor.	Tetradecanoylphorbol Acetate	62-65	mitogen-activated protein kinase kinase 7	Homo sapiens	145-177
18282472-4	2008	However, caspase-9/-3-mediated cytotoxicity can be induced in TPA-differentiated cells if they are pretreated with a protein kinase C (PKC) or a mitogen activated protein kinase (MEK) inhibitor.	Tetradecanoylphorbol Acetate	62-65	mitogen-activated protein kinase kinase 7	Homo sapiens	179-182
18282472-5	2008	Taken together, this study demonstrates that TPA-differentiated HL-60 cells inhibit caspases-9/-3-mediated cytotoxicity through the PKC and MEK signaling pathways.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase kinase 7	Homo sapiens	140-143
18061278-12	2008	Double staining with IL-4 or interferon-gamma (IFN-gamma) indicated that PMA and ionomycin stimulation induced 80% IL-10(+)/IFN-gamma(+) lymphocytes, while only 5% IL-10(+)/IL-4(+) cells were observed.	Tetradecanoylphorbol Acetate	73-76	interleukin 4	Equus caballus	21-25
18164693-5	2008	Topical application on mice ears of Tat-SOD also suppressed TPA-induced expression of proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 as well as cyclooxygenase-2 (COX-2) and production of PGE(2).	Tetradecanoylphorbol Acetate	60-63	tumor necrosis factor	Mus musculus	120-129
18164693-5	2008	Topical application on mice ears of Tat-SOD also suppressed TPA-induced expression of proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 as well as cyclooxygenase-2 (COX-2) and production of PGE(2).	Tetradecanoylphorbol Acetate	60-63	interleukin 1 beta	Mus musculus	131-139
18164693-5	2008	Topical application on mice ears of Tat-SOD also suppressed TPA-induced expression of proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 as well as cyclooxygenase-2 (COX-2) and production of PGE(2).	Tetradecanoylphorbol Acetate	60-63	interleukin 6	Mus musculus	145-149
18061278-12	2008	Double staining with IL-4 or interferon-gamma (IFN-gamma) indicated that PMA and ionomycin stimulation induced 80% IL-10(+)/IFN-gamma(+) lymphocytes, while only 5% IL-10(+)/IL-4(+) cells were observed.	Tetradecanoylphorbol Acetate	73-76	interleukin 4	Equus caballus	173-177
18167130-4	2008	The phosphorylation of ERK(1/2) and p38 MAPK was regulated by upregulated protein kinase C beta (PKC beta) in HCC cells through the integrated use of PKC beta RNA interference, the PKC beta specific inhibitor enzastaurin and a PKC activator phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	241-272	mitogen-activated protein kinase 3	Homo sapiens	23-30
18174170-3	2008	Moreover, NIH3T3 cells expressing the 4 CRUs of Ahnak showed enhanced c-Raf, MEK, and Erk phosphorylation in response to phorbol 12-myristate 13-acetate (PMA) compared with parental cells.	Tetradecanoylphorbol Acetate	121-152	AHNAK nucleoprotein (desmoyokin)	Mus musculus	48-53
18174170-3	2008	Moreover, NIH3T3 cells expressing the 4 CRUs of Ahnak showed enhanced c-Raf, MEK, and Erk phosphorylation in response to phorbol 12-myristate 13-acetate (PMA) compared with parental cells.	Tetradecanoylphorbol Acetate	121-152	mitogen-activated protein kinase 1	Mus musculus	86-89
18174170-3	2008	Moreover, NIH3T3 cells expressing the 4 CRUs of Ahnak showed enhanced c-Raf, MEK, and Erk phosphorylation in response to phorbol 12-myristate 13-acetate (PMA) compared with parental cells.	Tetradecanoylphorbol Acetate	154-157	AHNAK nucleoprotein (desmoyokin)	Mus musculus	48-53
18174170-3	2008	Moreover, NIH3T3 cells expressing the 4 CRUs of Ahnak showed enhanced c-Raf, MEK, and Erk phosphorylation in response to phorbol 12-myristate 13-acetate (PMA) compared with parental cells.	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase 1	Mus musculus	86-89
17914635-3	2008	We investigated the effect of bioactive ceramics on the expression of inflammatory cytokines, COX-2, and inducible NOS (iNOS) induced by phorbol 12-myristate 13-acetate (PMA) in rat VSMCs.	Tetradecanoylphorbol Acetate	137-168	nitric oxide synthase 2	Rattus norvegicus	105-118
18296647-4	2008	We report that tumor promoter 12-O-tetradecanoylphorbol-13-acetate exposure decreases protein levels of Pdcd4 in mouse skin papillomas and keratinocytes as well as in human HEK293 cells.	Tetradecanoylphorbol Acetate	30-66	programmed cell death 4	Mus musculus	104-109
17922475-6	2008	RESULTS: Both phorbol 12-myristate 13-acetate (PMA) [a protein kinase C (PKC) activator] and rosiglitazone increased TGFbeta expression and fibronectin and laminin release in C and T2D patients.	Tetradecanoylphorbol Acetate	14-45	transforming growth factor beta 1	Homo sapiens	117-124
17922475-6	2008	RESULTS: Both phorbol 12-myristate 13-acetate (PMA) [a protein kinase C (PKC) activator] and rosiglitazone increased TGFbeta expression and fibronectin and laminin release in C and T2D patients.	Tetradecanoylphorbol Acetate	14-45	fibronectin 1	Homo sapiens	140-151
17922475-6	2008	RESULTS: Both phorbol 12-myristate 13-acetate (PMA) [a protein kinase C (PKC) activator] and rosiglitazone increased TGFbeta expression and fibronectin and laminin release in C and T2D patients.	Tetradecanoylphorbol Acetate	47-50	transforming growth factor beta 1	Homo sapiens	117-124
17922475-6	2008	RESULTS: Both phorbol 12-myristate 13-acetate (PMA) [a protein kinase C (PKC) activator] and rosiglitazone increased TGFbeta expression and fibronectin and laminin release in C and T2D patients.	Tetradecanoylphorbol Acetate	47-50	fibronectin 1	Homo sapiens	140-151
17922475-11	2008	Rosiglitazone increased p38 activation more in C than in T2D patients; PMA-induced phosphorylation of ERK1/2 was similarly reduced in both cells.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase 3	Homo sapiens	102-108
17922475-13	2008	On the other hand, rosiglitazone quenches inflammation in both cell types, by counteracting PMA-induced phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	92-95	mitogen-activated protein kinase 3	Homo sapiens	123-129
17914635-3	2008	We investigated the effect of bioactive ceramics on the expression of inflammatory cytokines, COX-2, and inducible NOS (iNOS) induced by phorbol 12-myristate 13-acetate (PMA) in rat VSMCs.	Tetradecanoylphorbol Acetate	137-168	nitric oxide synthase 2	Rattus norvegicus	120-124
17914635-3	2008	We investigated the effect of bioactive ceramics on the expression of inflammatory cytokines, COX-2, and inducible NOS (iNOS) induced by phorbol 12-myristate 13-acetate (PMA) in rat VSMCs.	Tetradecanoylphorbol Acetate	170-173	nitric oxide synthase 2	Rattus norvegicus	105-118
17914635-3	2008	We investigated the effect of bioactive ceramics on the expression of inflammatory cytokines, COX-2, and inducible NOS (iNOS) induced by phorbol 12-myristate 13-acetate (PMA) in rat VSMCs.	Tetradecanoylphorbol Acetate	170-173	nitric oxide synthase 2	Rattus norvegicus	120-124
18088599-4	2008	Capillarisin has been found to suppress PMA-induced MMP-9 expression through inhibition of the NF-kappaB-dependent transcriptional activity of MMP-9 gene via p38 MAPK and JNK signaling pathways.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 14	Homo sapiens	158-161
17919781-3	2008	As was previously observed, phorbol 12-myristate 13-acetate (PMA) caused a decrease in biotinylated GLT-1.	Tetradecanoylphorbol Acetate	28-59	solute carrier family 1 member 2	Homo sapiens	100-105
17919781-3	2008	As was previously observed, phorbol 12-myristate 13-acetate (PMA) caused a decrease in biotinylated GLT-1.	Tetradecanoylphorbol Acetate	61-64	solute carrier family 1 member 2	Homo sapiens	100-105
17647275-4	2008	Thus, we investigate whether phorbol 12-myristate-13-acetate (PMA)-induced insulin resistance affects the increase of ApoB secretion.	Tetradecanoylphorbol Acetate	29-60	insulin	Homo sapiens	75-82
17647275-4	2008	Thus, we investigate whether phorbol 12-myristate-13-acetate (PMA)-induced insulin resistance affects the increase of ApoB secretion.	Tetradecanoylphorbol Acetate	62-65	apolipoprotein B	Homo sapiens	118-122
18208974-3	2008	We show that mice deficient for the receptor for advanced glycation end-products (RAGE) are resistant to DMBA/TPA-induced skin carcinogenesis and exhibit a severe defect in sustaining inflammation during the promotion phase.	Tetradecanoylphorbol Acetate	110-113	advanced glycosylation end product-specific receptor	Mus musculus	36-80
18208974-3	2008	We show that mice deficient for the receptor for advanced glycation end-products (RAGE) are resistant to DMBA/TPA-induced skin carcinogenesis and exhibit a severe defect in sustaining inflammation during the promotion phase.	Tetradecanoylphorbol Acetate	110-113	advanced glycosylation end product-specific receptor	Mus musculus	82-86
17647275-4	2008	Thus, we investigate whether phorbol 12-myristate-13-acetate (PMA)-induced insulin resistance affects the increase of ApoB secretion.	Tetradecanoylphorbol Acetate	29-60	apolipoprotein B	Homo sapiens	118-122
18208974-4	2008	Accordingly, RAGE is required for TPA-induced up-regulation of proinflammatory mediators, maintenance of immune cell infiltration, and epidermal hyperplasia.	Tetradecanoylphorbol Acetate	34-37	advanced glycosylation end product-specific receptor	Mus musculus	13-17
17647275-4	2008	Thus, we investigate whether phorbol 12-myristate-13-acetate (PMA)-induced insulin resistance affects the increase of ApoB secretion.	Tetradecanoylphorbol Acetate	62-65	insulin	Homo sapiens	75-82
18208974-6	2008	Finally, bone marrow chimera experiments revealed that RAGE expression on immune cells, but not keratinocytes or endothelial cells, is essential for TPA-induced dermal infiltration and epidermal hyperplasia.	Tetradecanoylphorbol Acetate	149-152	advanced glycosylation end product-specific receptor	Mus musculus	55-59
17647275-7	2008	Additionally, PMA induced activation of c-jun N-terminal kinase (JNK) and protein kinase C (PKC) isoforms (alpha, betaI, delta, zeta, theta), and reduced AKT8 virus oncogene cellular homolog (AKT) activation in a time dependent manner.	Tetradecanoylphorbol Acetate	14-17	mitogen-activated protein kinase 8	Homo sapiens	65-68
17647275-10	2008	From the results, it was concluded that PMA-induced insulin resistance, through induction of serine phosphorylation of IRS1 mediated by activated JNK and PKCs, increases ApoB secretion in Chang liver cells.	Tetradecanoylphorbol Acetate	40-43	insulin	Homo sapiens	52-59
18070609-2	2008	Here, it is shown that the proinflammatory mediator lipopolysaccharide (LPS) inhibits the induction of Prx I expression and promoter activity by the phorbol ester 12-O-tetradecanoylphorbol- 13-acetate (TPA) in RAW264.7 monocytes, but not that of cyclooxygenase-2.	Tetradecanoylphorbol Acetate	163-200	prostaglandin-endoperoxide synthase 2	Homo sapiens	246-262
17647275-10	2008	From the results, it was concluded that PMA-induced insulin resistance, through induction of serine phosphorylation of IRS1 mediated by activated JNK and PKCs, increases ApoB secretion in Chang liver cells.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 8	Homo sapiens	146-149
17647275-10	2008	From the results, it was concluded that PMA-induced insulin resistance, through induction of serine phosphorylation of IRS1 mediated by activated JNK and PKCs, increases ApoB secretion in Chang liver cells.	Tetradecanoylphorbol Acetate	40-43	apolipoprotein B	Homo sapiens	170-174
17964626-6	2008	Here, we report that, besides the MEK/ERK pathway, the JNK and p38 MAPK pathways also mediate TPA-induced KSHV reactivation from latency.	Tetradecanoylphorbol Acetate	94-97	mitogen-activated protein kinase 8	Homo sapiens	55-58
17700521-3	2008	Keratinocytes from K5.Stat3C mice showed increased survival following exposure to 7,12-dimethylbenz[a]anthracene (DMBA) and enhanced proliferation following exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	169-205	signal transducer and activator of transcription 3	Mus musculus	22-28
17700521-3	2008	Keratinocytes from K5.Stat3C mice showed increased survival following exposure to 7,12-dimethylbenz[a]anthracene (DMBA) and enhanced proliferation following exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	207-210	signal transducer and activator of transcription 3	Mus musculus	22-28
17700521-4	2008	In two-stage chemical carcinogenesis experiments using DMBA as the tumor initiator and TPA as the promoter, K5.Stat3C mice developed skin tumors with a shorter latency and in much greater number compared to non-transgenic littermates.	Tetradecanoylphorbol Acetate	87-90	signal transducer and activator of transcription 3	Mus musculus	111-117
18070596-4	2008	Further mechanistic studies revealed that irisolidone inhibits the binding of NF-kappaB and AP-1 to the MMP-9 promoter and suppresses the PMA-induced phosphorylation of ERK and JNK, which are upstream signaling molecules in MMP-9 expression.	Tetradecanoylphorbol Acetate	138-141	mitogen-activated protein kinase 8	Homo sapiens	177-180
17964626-6	2008	Here, we report that, besides the MEK/ERK pathway, the JNK and p38 MAPK pathways also mediate TPA-induced KSHV reactivation from latency.	Tetradecanoylphorbol Acetate	94-97	mitogen-activated protein kinase 14	Homo sapiens	63-66
17964626-8	2008	TPA treatment enhanced the levels of activated ERK and p38 but not those of activated JNK.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	47-50
17964626-8	2008	TPA treatment enhanced the levels of activated ERK and p38 but not those of activated JNK.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	55-58
18174253-5	2008	Importantly, the inhibition of p12-LOX in JB6 P+ cells by baicalein, a specific inhibitor or small interfering RNA significantly suppressed TPA-induced transformation.	Tetradecanoylphorbol Acetate	140-143	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	31-34
18053806-6	2008	MEK kinase assay using myelin basic protein (MBP) revealed that TPA-augmented MEK activity in HT-1080 cells and that the augmented MEK activity was diminished by nobiletin treatment.	Tetradecanoylphorbol Acetate	64-67	mitogen-activated protein kinase kinase 7	Homo sapiens	0-3
18053806-6	2008	MEK kinase assay using myelin basic protein (MBP) revealed that TPA-augmented MEK activity in HT-1080 cells and that the augmented MEK activity was diminished by nobiletin treatment.	Tetradecanoylphorbol Acetate	64-67	mitogen-activated protein kinase kinase 7	Homo sapiens	78-81
18053806-6	2008	MEK kinase assay using myelin basic protein (MBP) revealed that TPA-augmented MEK activity in HT-1080 cells and that the augmented MEK activity was diminished by nobiletin treatment.	Tetradecanoylphorbol Acetate	64-67	mitogen-activated protein kinase kinase 7	Homo sapiens	78-81
18245498-4	2008	The activation of activator protein-1 and nuclear factor-kappaB induced by TPA was dose dependently inhibited by RWE or quercetin treatment.	Tetradecanoylphorbol Acetate	75-78	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-37
18222974-9	2008	In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells.	Tetradecanoylphorbol Acetate	33-64	tumor necrosis factor	Homo sapiens	126-153
18222974-9	2008	In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells.	Tetradecanoylphorbol Acetate	33-64	interleukin 6	Homo sapiens	155-168
18222974-9	2008	In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells.	Tetradecanoylphorbol Acetate	33-64	interleukin 6	Homo sapiens	170-174
18222974-9	2008	In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells.	Tetradecanoylphorbol Acetate	33-64	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
17654516-3	2008	We investigated whether the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) may induce melanocyte resistance to TGF-beta.	Tetradecanoylphorbol Acetate	58-94	transforming growth factor beta 1	Homo sapiens	137-145
17662042-9	2008	IFN-gamma inhibited phorbol 12-myristate 13-acetate (PMA)-induced release of IL-8 and CCL1 (by 47 and 38%).	Tetradecanoylphorbol Acetate	20-51	interferon gamma	Homo sapiens	0-9
17662042-9	2008	IFN-gamma inhibited phorbol 12-myristate 13-acetate (PMA)-induced release of IL-8 and CCL1 (by 47 and 38%).	Tetradecanoylphorbol Acetate	20-51	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
17662042-9	2008	IFN-gamma inhibited phorbol 12-myristate 13-acetate (PMA)-induced release of IL-8 and CCL1 (by 47 and 38%).	Tetradecanoylphorbol Acetate	20-51	C-C motif chemokine ligand 1	Homo sapiens	86-90
17662042-9	2008	IFN-gamma inhibited phorbol 12-myristate 13-acetate (PMA)-induced release of IL-8 and CCL1 (by 47 and 38%).	Tetradecanoylphorbol Acetate	53-56	interferon gamma	Homo sapiens	0-9
17662042-9	2008	IFN-gamma inhibited phorbol 12-myristate 13-acetate (PMA)-induced release of IL-8 and CCL1 (by 47 and 38%).	Tetradecanoylphorbol Acetate	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
17662042-9	2008	IFN-gamma inhibited phorbol 12-myristate 13-acetate (PMA)-induced release of IL-8 and CCL1 (by 47 and 38%).	Tetradecanoylphorbol Acetate	53-56	C-C motif chemokine ligand 1	Homo sapiens	86-90
18048350-5	2008	Phorbol 12-myristate 13-acetate (a PKC activator) had similar effects.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	35-38
17654516-3	2008	We investigated whether the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) may induce melanocyte resistance to TGF-beta.	Tetradecanoylphorbol Acetate	96-99	transforming growth factor beta 1	Homo sapiens	137-145
17654516-7	2008	PKC-alpha expression and phosphorylation were almost completely downregulated under combined treatment with TGF-beta + TPA at 24 and 72 h, as shown by immunoblots.	Tetradecanoylphorbol Acetate	119-122	protein kinase C alpha	Homo sapiens	0-9
17654516-8	2008	Confocal microscopy demonstrated that TGF-beta-induced nuclear accumulation of PKC-alpha was abolished in the presence of TPA at the same time points.	Tetradecanoylphorbol Acetate	122-125	transforming growth factor beta 1	Homo sapiens	38-46
17654516-8	2008	Confocal microscopy demonstrated that TGF-beta-induced nuclear accumulation of PKC-alpha was abolished in the presence of TPA at the same time points.	Tetradecanoylphorbol Acetate	122-125	protein kinase C alpha	Homo sapiens	79-88
17654516-11	2008	Smad-dependent transcriptional activity was suppressed in TGF-beta-treated melanocytes in the presence of TPA, as well as in ALK5 (constitutively active type I TGF-beta receptor)- or Smad3 + Smad4-transfected melanocytes in the presence of Ro-31-8220.	Tetradecanoylphorbol Acetate	106-109	transforming growth factor beta 1	Homo sapiens	58-66
18166007-6	2008	By inhibiting PMA-mediated transactivation of the epidermal growth factor receptor (EGFR), a pathway critically required for normal HMEC function, we found that the secretion of specific matrix metalloproteases was also coordinately regulated through EGFR transactivation.	Tetradecanoylphorbol Acetate	14-17	epidermal growth factor receptor	Homo sapiens	50-82
17713572-8	2008	Finally, PPARbeta/delta KO mice displayed increased inflammation in response to 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	80-116	peroxisome proliferator activator receptor delta	Mus musculus	9-17
17713572-8	2008	Finally, PPARbeta/delta KO mice displayed increased inflammation in response to 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	118-121	peroxisome proliferator activator receptor delta	Mus musculus	9-17
18166007-6	2008	By inhibiting PMA-mediated transactivation of the epidermal growth factor receptor (EGFR), a pathway critically required for normal HMEC function, we found that the secretion of specific matrix metalloproteases was also coordinately regulated through EGFR transactivation.	Tetradecanoylphorbol Acetate	14-17	epidermal growth factor receptor	Homo sapiens	84-88
18166007-6	2008	By inhibiting PMA-mediated transactivation of the epidermal growth factor receptor (EGFR), a pathway critically required for normal HMEC function, we found that the secretion of specific matrix metalloproteases was also coordinately regulated through EGFR transactivation.	Tetradecanoylphorbol Acetate	14-17	epidermal growth factor receptor	Homo sapiens	251-255
18177545-4	2008	The TNF-alpha-induced PA release was significantly enhanced in the presence of phorbol-12-myristate-13-acetate (PMA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	79-110	tumor necrosis factor	Homo sapiens	4-13
18177545-4	2008	The TNF-alpha-induced PA release was significantly enhanced in the presence of phorbol-12-myristate-13-acetate (PMA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	112-115	tumor necrosis factor	Homo sapiens	4-13
18480596-12	2008	On the other hand, MLC-2C mRNA was expressed in untreated monocytic cell lines (U937 and A-THP-1) and HL-60 differentiated into monocyte/macrophage cell lineage by TPA treatment.	Tetradecanoylphorbol Acetate	164-167	myosin light chain 9	Homo sapiens	19-25
18590109-4	2008	Spontaneous production of IL-2, IL-4, IFNgamma (IFNgamma) and TNFalpha (TNFalpha) by CD3(+) and CD3(-) lymphocytes was estimated after 4 hours of incubation in 37 degrees C with phorbol-12-myristate-13-acetate (PMA, 50 ng/ml, Sigma, France), ionomycin (1 mcg/ml, Sigma, France) and brefeldin A (10 mcg/ml, Sigma, France).	Tetradecanoylphorbol Acetate	178-209	tumor necrosis factor	Homo sapiens	72-80
18084034-6	2008	This PAP activity was also activated by stimulation of ERK with phorbol-12-myristate-13-acetate in vivo.	Tetradecanoylphorbol Acetate	64-95	mitogen-activated protein kinase 1	Homo sapiens	55-58
18257749-2	2008	2 Inhibitors of this kinase (PP2 and Src Inhibitor II) decreased ( approximately 50-75%) noradrenaline- (NA) and phorbol myristate acetate-mediated receptor phosphorylation.	Tetradecanoylphorbol Acetate	113-138	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	37-40
18257749-5	2008	In cells treated with NA or phorbol myristate acetate the amount of coimmunoprecipitated GRK2 and GRK3 increased ( approximately 2- to 3-fold), while treatment with ET-1 only augmented the amount of coimmunoprecipitated GRK2 ( approximately 2-fold).	Tetradecanoylphorbol Acetate	28-53	G protein-coupled receptor kinase 2	Homo sapiens	89-93
18257749-5	2008	In cells treated with NA or phorbol myristate acetate the amount of coimmunoprecipitated GRK2 and GRK3 increased ( approximately 2- to 3-fold), while treatment with ET-1 only augmented the amount of coimmunoprecipitated GRK2 ( approximately 2-fold).	Tetradecanoylphorbol Acetate	28-53	endothelin 1	Homo sapiens	165-169
18257749-5	2008	In cells treated with NA or phorbol myristate acetate the amount of coimmunoprecipitated GRK2 and GRK3 increased ( approximately 2- to 3-fold), while treatment with ET-1 only augmented the amount of coimmunoprecipitated GRK2 ( approximately 2-fold).	Tetradecanoylphorbol Acetate	28-53	G protein-coupled receptor kinase 2	Homo sapiens	220-224
18024477-0	2008	Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 1	Homo sapiens	95-98
18024477-0	2008	Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	24-27	nuclear factor kappa B subunit 1	Homo sapiens	162-171
18024477-7	2008	Moreover, LAB also strongly inhibited PMA-stimulated nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) DNA-binding activities of HepG(2) cells in dose-dependent manners.	Tetradecanoylphorbol Acetate	38-41	nuclear factor kappa B subunit 1	Homo sapiens	77-86
18296860-2	2008	ATRA enhanced the production of IL-2 stimulated by TPA, but suppressed that stimulated by PHA.	Tetradecanoylphorbol Acetate	51-54	interleukin 2	Homo sapiens	32-36
18296860-6	2008	Since PKC- beta1 has been suggested to be important for the secretion and gene expression of IL-2 and since the activator protein-l binding site is present in the promoter of the IL-2 gene, these findings may explain the differences in ATRA"s effects on TPA- and PHA-stimulated IL-2 expression.	Tetradecanoylphorbol Acetate	254-257	interleukin 2	Homo sapiens	179-183
18296860-6	2008	Since PKC- beta1 has been suggested to be important for the secretion and gene expression of IL-2 and since the activator protein-l binding site is present in the promoter of the IL-2 gene, these findings may explain the differences in ATRA"s effects on TPA- and PHA-stimulated IL-2 expression.	Tetradecanoylphorbol Acetate	254-257	interleukin 2	Homo sapiens	179-183
17986621-3	2008	Therefore, we examined the role of PLD in hBD-2 up-regulation by cell wall extract of Fusobacterium nucleatum and phorbol 12-myristate 13-acetate (PMA), two known hBD-2 activators.	Tetradecanoylphorbol Acetate	114-145	defensin beta 4A	Homo sapiens	42-47
17986621-3	2008	Therefore, we examined the role of PLD in hBD-2 up-regulation by cell wall extract of Fusobacterium nucleatum and phorbol 12-myristate 13-acetate (PMA), two known hBD-2 activators.	Tetradecanoylphorbol Acetate	147-150	defensin beta 4A	Homo sapiens	42-47
18079967-5	2008	DMBA/TPA-treated TRAIL-R-deficient mice showed neither an increase in number or growth rate of benign papillomas nor an increase in the rate of progression to squamous cell carcinoma.	Tetradecanoylphorbol Acetate	5-8	TNF superfamily member 10	Homo sapiens	17-22
18679052-7	2008	RESULTS: In vitro incubation of macrophages with 10 nM DOMP decreased oxidative burst, after 30 min, whereas the PMA-induced burst was decreased by DOMP 10 nM after 2 and 4 h. Treatment with PRL (10 and 100 nM) for 30 min decreased oxidative burst and rate of phagocytosis (10 nM).	Tetradecanoylphorbol Acetate	113-116	prolactin	Rattus norvegicus	191-194
17676580-6	2008	Western blot analysis using a CD18 antibody targeted against the intracellular domain revealed reduced levels of full-length CD18 after stimulation of neutrophils with either fluid shear stress or with the Ca2+ ionophore phorbol 12-myristate 13-acetate (PMA; 100 nM) in the presence of exogenous cathepsin B (0.5 U/ml).	Tetradecanoylphorbol Acetate	254-257	integrin subunit beta 2	Homo sapiens	30-34
17676580-6	2008	Western blot analysis using a CD18 antibody targeted against the intracellular domain revealed reduced levels of full-length CD18 after stimulation of neutrophils with either fluid shear stress or with the Ca2+ ionophore phorbol 12-myristate 13-acetate (PMA; 100 nM) in the presence of exogenous cathepsin B (0.5 U/ml).	Tetradecanoylphorbol Acetate	254-257	integrin subunit beta 2	Homo sapiens	125-129
17662038-4	2008	There was a significant increase in the percentage of CD4+ and CD8+ T cells producing IL-4 and IL-13 and decrease in the percentage of CD4+ and CD8+ T cells producing IFN-gamma upon in vitro stimulation with phorbol 12-myristate 13-acetate and ionomycin in children with AD compared to healthy ones.	Tetradecanoylphorbol Acetate	208-239	CD4 molecule	Homo sapiens	54-57
17662038-4	2008	There was a significant increase in the percentage of CD4+ and CD8+ T cells producing IL-4 and IL-13 and decrease in the percentage of CD4+ and CD8+ T cells producing IFN-gamma upon in vitro stimulation with phorbol 12-myristate 13-acetate and ionomycin in children with AD compared to healthy ones.	Tetradecanoylphorbol Acetate	208-239	interleukin 4	Homo sapiens	86-90
17662038-4	2008	There was a significant increase in the percentage of CD4+ and CD8+ T cells producing IL-4 and IL-13 and decrease in the percentage of CD4+ and CD8+ T cells producing IFN-gamma upon in vitro stimulation with phorbol 12-myristate 13-acetate and ionomycin in children with AD compared to healthy ones.	Tetradecanoylphorbol Acetate	208-239	interleukin 13	Homo sapiens	95-100
17662038-4	2008	There was a significant increase in the percentage of CD4+ and CD8+ T cells producing IL-4 and IL-13 and decrease in the percentage of CD4+ and CD8+ T cells producing IFN-gamma upon in vitro stimulation with phorbol 12-myristate 13-acetate and ionomycin in children with AD compared to healthy ones.	Tetradecanoylphorbol Acetate	208-239	CD4 molecule	Homo sapiens	135-138
17662038-4	2008	There was a significant increase in the percentage of CD4+ and CD8+ T cells producing IL-4 and IL-13 and decrease in the percentage of CD4+ and CD8+ T cells producing IFN-gamma upon in vitro stimulation with phorbol 12-myristate 13-acetate and ionomycin in children with AD compared to healthy ones.	Tetradecanoylphorbol Acetate	208-239	interferon gamma	Homo sapiens	167-176
17767925-4	2008	In an attempt to link the NF-kappaB activation and COX-2 induction during mammary carcinogenesis, we have examined the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA), a prototype tumor promoter and a mitogen, on NF-kappaB activation and COX-2 expression in the immortalized human breast epithelial cell line (MCF10A).	Tetradecanoylphorbol Acetate	130-166	nuclear factor kappa B subunit 1	Homo sapiens	219-228
17767925-5	2008	Treatment of MCF10A cells with TPA resulted in transient induction of NF-kappaB DNA binding with maximal activation observed at 30 min.	Tetradecanoylphorbol Acetate	31-34	nuclear factor kappa B subunit 1	Homo sapiens	70-79
17767925-9	2008	Treatment of cells with the NF-kappaB inhibitor pyrrolidine dithiocarbamate resulted in significant suppression of TPA-induced COX-2 expression.	Tetradecanoylphorbol Acetate	115-118	nuclear factor kappa B subunit 1	Homo sapiens	28-37
17767925-9	2008	Treatment of cells with the NF-kappaB inhibitor pyrrolidine dithiocarbamate resulted in significant suppression of TPA-induced COX-2 expression.	Tetradecanoylphorbol Acetate	115-118	prostaglandin-endoperoxide synthase 2	Homo sapiens	127-132
17767925-10	2008	TPA induced activation of ERK1/2 and p38 mitogen-activated protein kinases (MAPK) via phosphorylation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	26-32
17767925-10	2008	TPA induced activation of ERK1/2 and p38 mitogen-activated protein kinases (MAPK) via phosphorylation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	37-40
17767925-10	2008	TPA induced activation of ERK1/2 and p38 mitogen-activated protein kinases (MAPK) via phosphorylation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	76-80
17767925-11	2008	PD98059 (ERK inhibitor) and SB203580 (p38 MAPK inhibitor) down-regulated the COX-2 expression induced by TPA.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase 1	Homo sapiens	9-12
17767925-11	2008	PD98059 (ERK inhibitor) and SB203580 (p38 MAPK inhibitor) down-regulated the COX-2 expression induced by TPA.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase 1	Homo sapiens	38-41
17767925-11	2008	PD98059 (ERK inhibitor) and SB203580 (p38 MAPK inhibitor) down-regulated the COX-2 expression induced by TPA.	Tetradecanoylphorbol Acetate	105-108	prostaglandin-endoperoxide synthase 2	Homo sapiens	77-82
17767925-12	2008	Furthermore, TPA-induced COX-2 induction as well as NF-kappaB activation was blocked in MCF10A cells transfected with dominant negative mutant ERK1/2 or p38 MAPK.	Tetradecanoylphorbol Acetate	13-16	prostaglandin-endoperoxide synthase 2	Homo sapiens	25-30
17767925-12	2008	Furthermore, TPA-induced COX-2 induction as well as NF-kappaB activation was blocked in MCF10A cells transfected with dominant negative mutant ERK1/2 or p38 MAPK.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 3	Homo sapiens	143-149
17767925-12	2008	Furthermore, TPA-induced COX-2 induction as well as NF-kappaB activation was blocked in MCF10A cells transfected with dominant negative mutant ERK1/2 or p38 MAPK.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 1	Homo sapiens	153-156
17767925-13	2008	These results suggest that both p38 and ERK MAPKs activates NF-kappaB signaling, which in turn induces COX-2 expression in TPA-stimulated human mammary epithelial cells.	Tetradecanoylphorbol Acetate	123-126	mitogen-activated protein kinase 1	Homo sapiens	32-35
17767925-13	2008	These results suggest that both p38 and ERK MAPKs activates NF-kappaB signaling, which in turn induces COX-2 expression in TPA-stimulated human mammary epithelial cells.	Tetradecanoylphorbol Acetate	123-126	mitogen-activated protein kinase 1	Homo sapiens	40-43
17767925-13	2008	These results suggest that both p38 and ERK MAPKs activates NF-kappaB signaling, which in turn induces COX-2 expression in TPA-stimulated human mammary epithelial cells.	Tetradecanoylphorbol Acetate	123-126	nuclear factor kappa B subunit 1	Homo sapiens	60-69
17767925-13	2008	These results suggest that both p38 and ERK MAPKs activates NF-kappaB signaling, which in turn induces COX-2 expression in TPA-stimulated human mammary epithelial cells.	Tetradecanoylphorbol Acetate	123-126	prostaglandin-endoperoxide synthase 2	Homo sapiens	103-108
17955327-4	2008	In our in vitro studies, treatment of primary cultures of adult feline cardiomyocytes (cardiocytes) with 100 nM endothelin, 9 mM RGD, 100 nM insulin, or 100 nM TPA activated mTOR via distinct signaling pathways and resulted in an increased proportion of polysome-bound rpL32 mRNA.	Tetradecanoylphorbol Acetate	160-163	mechanistic target of rapamycin kinase	Homo sapiens	174-178
17955327-4	2008	In our in vitro studies, treatment of primary cultures of adult feline cardiomyocytes (cardiocytes) with 100 nM endothelin, 9 mM RGD, 100 nM insulin, or 100 nM TPA activated mTOR via distinct signaling pathways and resulted in an increased proportion of polysome-bound rpL32 mRNA.	Tetradecanoylphorbol Acetate	160-163	ribosomal protein L32	Homo sapiens	269-274
18024477-9	2008	In conclusion, we demonstrated that the anti-invasive effects of the LAB on the PMA-induced HepG(2) cells might be through inhibiting the phosphorylation of ERK1/2 and reducing AP-1 and NF-kappaB DNA-binding activities, leading to downregulation of MMP-9 expression.	Tetradecanoylphorbol Acetate	80-83	mitogen-activated protein kinase 3	Homo sapiens	157-163
18024477-9	2008	In conclusion, we demonstrated that the anti-invasive effects of the LAB on the PMA-induced HepG(2) cells might be through inhibiting the phosphorylation of ERK1/2 and reducing AP-1 and NF-kappaB DNA-binding activities, leading to downregulation of MMP-9 expression.	Tetradecanoylphorbol Acetate	80-83	nuclear factor kappa B subunit 1	Homo sapiens	186-195
18197392-0	2008	hnRNP-R regulates the PMA-induced c-fos expression in retinal cells.	Tetradecanoylphorbol Acetate	22-25	heterogeneous nuclear ribonucleoprotein R	Rattus norvegicus	0-7
19088454-9	2008	Similarly, treatment with 5 microM forskolin as well as stimulation of protein kinase C with phorbolester phorbol 12 myristate 13 acetate (100 nM) enhanced DeltapH/min to almost identical values in pdk1(hm) and in pdk1(wt)mice.	Tetradecanoylphorbol Acetate	106-137	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	198-206
19088454-9	2008	Similarly, treatment with 5 microM forskolin as well as stimulation of protein kinase C with phorbolester phorbol 12 myristate 13 acetate (100 nM) enhanced DeltapH/min to almost identical values in pdk1(hm) and in pdk1(wt)mice.	Tetradecanoylphorbol Acetate	106-137	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	198-202
17855021-5	2008	For the phorbol myristate acetate stimulation of Jurkat cells, effects on NFkappaB expression were mixed.	Tetradecanoylphorbol Acetate	8-33	nuclear factor kappa B subunit 1	Homo sapiens	74-82
18207029-4	2008	Culture in the presence of TNF-alpha induced some differentiation, but only treatment with PMA and ionomycin (with or without prior culture in GM-CSF and IL-4) induced morphological and phenotypic changes consistent with DC-like maturation, and even these maximally differentiated KG-1 cells showed lower levels of surface marker expression, macromolecular endocytosis, and ability to stimulate in allogeneic MLR compared with in vitro monocyte-derived DCs.	Tetradecanoylphorbol Acetate	91-94	interleukin 4	Homo sapiens	154-158
18214799-4	2008	Isolated peripheral blood mononuclear cells from women with endometriosis and uterine leiomyoma were stimulated with PMA and ionomycin or with LPS to induce intracellular synthesis of TNF-alpha, IFN-gamma, and IL-8 in subpopulations of CD3+ cells and TNF-alpha, IL-6, IL-10, MCP-1, and IL-8 in CD14+ cells.	Tetradecanoylphorbol Acetate	117-120	interferon gamma	Homo sapiens	195-204
18836276-7	2008	PMA treatment induced the phosphorylation of ERK1/2 with a time course that is consistent with a role in the cAMP response.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	45-51
18234971-8	2008	Furthermore, inhibition of c-Jun/activator protein 1 pathway or JNKs/c-Jun pathway by overexpression of dominant negative mutants of c-Jun, or MKK4 and MKK7 together, resulted in impairment of COX-2 induction, suggesting that JNK1/c-Jun/activator protein 1 pathway is involved in TPA-associated COX-2 induction.	Tetradecanoylphorbol Acetate	280-283	mitogen-activated protein kinase kinase 7	Mus musculus	152-156
18637422-6	2008	Blood sample was obtained from patients and examined for the expression of IFN-gamma and TNF-alpha by intracellular staining procedure after stimulation with PMA/ionomycin and allergen.	Tetradecanoylphorbol Acetate	158-161	interferon gamma	Homo sapiens	75-84
18590109-4	2008	Spontaneous production of IL-2, IL-4, IFNgamma (IFNgamma) and TNFalpha (TNFalpha) by CD3(+) and CD3(-) lymphocytes was estimated after 4 hours of incubation in 37 degrees C with phorbol-12-myristate-13-acetate (PMA, 50 ng/ml, Sigma, France), ionomycin (1 mcg/ml, Sigma, France) and brefeldin A (10 mcg/ml, Sigma, France).	Tetradecanoylphorbol Acetate	211-214	tumor necrosis factor	Homo sapiens	72-80
17928287-7	2007	The binding of TCF11/MafG to the iNOS promoter could be enhanced by phorbol 12-myristate 13-acetate and suppressed by the protein kinase C inhibitor staurosporine.	Tetradecanoylphorbol Acetate	68-99	MAF bZIP transcription factor G	Rattus norvegicus	21-25
17928287-7	2007	The binding of TCF11/MafG to the iNOS promoter could be enhanced by phorbol 12-myristate 13-acetate and suppressed by the protein kinase C inhibitor staurosporine.	Tetradecanoylphorbol Acetate	68-99	nitric oxide synthase 2	Rattus norvegicus	33-37
17869243-5	2007	In transiently transfected Ltk(-) fibroblast cells, 2-min preactivation of PKC with 12-O-tetradecanoyl 4beta-phorbol 13alpha-acetate (TPA) completely inhibited calcium mobilization induced by the dopamine D(2S) receptor, but not the dopamine D(2L) variant.	Tetradecanoylphorbol Acetate	134-137	leukocyte receptor tyrosine kinase	Rattus norvegicus	27-30
18054415-6	2007	Intracellular expression of IFN-gamma and IL-4 by CD3+CD8(-) (Th1 and Th2, respectively) and CD3+CD8+ (Tc1 and Tc2, respectively) was estimated by flow cytometry in peripheral blood cells after stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	211-214	interferon gamma	Homo sapiens	28-37
18067864-0	2007	Phorbol myristate acetate-induced Egr-1 expression is suppressed by phospholipase D isozymes in human glioma cells.	Tetradecanoylphorbol Acetate	0-25	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	68-83
18067864-2	2007	Here, we found that overexpression of phospholipase D (PLD) isozymes decreased tumor promoter phorbol myristate acetate (PMA)-induced Egr-1 expression and transactivation in glioma cells.	Tetradecanoylphorbol Acetate	94-119	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	38-53
18067864-2	2007	Here, we found that overexpression of phospholipase D (PLD) isozymes decreased tumor promoter phorbol myristate acetate (PMA)-induced Egr-1 expression and transactivation in glioma cells.	Tetradecanoylphorbol Acetate	94-119	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	55-58
18067864-2	2007	Here, we found that overexpression of phospholipase D (PLD) isozymes decreased tumor promoter phorbol myristate acetate (PMA)-induced Egr-1 expression and transactivation in glioma cells.	Tetradecanoylphorbol Acetate	121-124	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	38-53
18067864-2	2007	Here, we found that overexpression of phospholipase D (PLD) isozymes decreased tumor promoter phorbol myristate acetate (PMA)-induced Egr-1 expression and transactivation in glioma cells.	Tetradecanoylphorbol Acetate	121-124	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	55-58
18067864-6	2007	Taken together, these results suggest that elevated expression and activity of PLD attenuate PMA-induced Egr-1 expression via PI3K pathway.	Tetradecanoylphorbol Acetate	93-96	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	79-82
18054415-6	2007	Intracellular expression of IFN-gamma and IL-4 by CD3+CD8(-) (Th1 and Th2, respectively) and CD3+CD8+ (Tc1 and Tc2, respectively) was estimated by flow cytometry in peripheral blood cells after stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	211-214	interleukin 4	Homo sapiens	42-46
18077438-9	2007	Although inhibitors of PKC had no effect on this suppression, MAPK inhibitors completely prevented the TPA effect.	Tetradecanoylphorbol Acetate	103-106	mitogen-activated protein kinase 3	Homo sapiens	62-66
17933457-12	2007	Lastly, the pharmacological AP-1 activator phorbol myristate acetate increased AP-1 binding, trans-activated the wild-type but not the AP-1 mutant NOS3 promoter and dose-dependently stimulated UAEC NOS3 and c-Jun protein expression.	Tetradecanoylphorbol Acetate	43-68	nitric oxide synthase, endothelial	Ovis aries	147-151
17933457-12	2007	Lastly, the pharmacological AP-1 activator phorbol myristate acetate increased AP-1 binding, trans-activated the wild-type but not the AP-1 mutant NOS3 promoter and dose-dependently stimulated UAEC NOS3 and c-Jun protein expression.	Tetradecanoylphorbol Acetate	43-68	nitric oxide synthase, endothelial	Ovis aries	198-202
17942077-0	2007	Isoform-specific translocation of PKC isoforms in NIH3T3 cells by TPA.	Tetradecanoylphorbol Acetate	66-69	protein kinase C, alpha	Mus musculus	34-37
17942077-4	2007	The intracellular localization of the specific PKC isoforms was then examined by fluorescence microscopy after transient transfection of the respective PKC-GFP expression vector into NIH3T3 cells and subsequent TPA stimulation.	Tetradecanoylphorbol Acetate	211-214	protein kinase C, alpha	Mus musculus	47-50
17942077-7	2007	We also observed that PKCalpha, beta1, beta2, gamma, delta, epsilon, and eta translocate to the plasma membrane within 10 min of the start of TPA treatment, while the cellular localizations of PKCzeta and iota were not affected by TPA.	Tetradecanoylphorbol Acetate	142-145	protein kinase C, alpha	Mus musculus	22-30
17942077-7	2007	We also observed that PKCalpha, beta1, beta2, gamma, delta, epsilon, and eta translocate to the plasma membrane within 10 min of the start of TPA treatment, while the cellular localizations of PKCzeta and iota were not affected by TPA.	Tetradecanoylphorbol Acetate	231-234	protein kinase C, alpha	Mus musculus	22-30
17652337-0	2007	Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate represses sod2 induction in vivo: the negative role of p50.	Tetradecanoylphorbol Acetate	20-56	nuclear factor kappa B subunit 1	Homo sapiens	112-115
17880928-8	2007	Furthermore, Rh2 significantly repressed the PMA-mediated activation of p38 MAPK, ERK and JNK, which are upstream modulators of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase 1	Homo sapiens	82-85
17880928-8	2007	Furthermore, Rh2 significantly repressed the PMA-mediated activation of p38 MAPK, ERK and JNK, which are upstream modulators of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase 8	Homo sapiens	90-93
17652337-7	2007	During the activation phase, the levels of p50, p65, specificity protein 1 (Sp1) and nucleophosmin (NPM) increase after TPA treatments.	Tetradecanoylphorbol Acetate	120-123	nuclear factor kappa B subunit 1	Homo sapiens	43-46
17652337-7	2007	During the activation phase, the levels of p50, p65, specificity protein 1 (Sp1) and nucleophosmin (NPM) increase after TPA treatments.	Tetradecanoylphorbol Acetate	120-123	Sp1 transcription factor	Homo sapiens	53-74
17652337-8	2007	Sustained treatments with TPA lead to further increase of p50 but not p65, Sp1 or NPM, suggesting that excess p50 may have inhibitory effects leading to the suppression of MnSOD.	Tetradecanoylphorbol Acetate	26-29	nuclear factor kappa B subunit 1	Homo sapiens	58-61
17652337-8	2007	Sustained treatments with TPA lead to further increase of p50 but not p65, Sp1 or NPM, suggesting that excess p50 may have inhibitory effects leading to the suppression of MnSOD.	Tetradecanoylphorbol Acetate	26-29	nuclear factor kappa B subunit 1	Homo sapiens	110-113
17652337-10	2007	These findings identify p50 as having a negative effect on MnSOD induction upon repeated applications of TPA and provide an insight into a cause for the reduction of MnSOD expression during early stages of skin carcinogenesis.	Tetradecanoylphorbol Acetate	105-108	nuclear factor kappa B subunit 1	Homo sapiens	24-27
18090122-3	2007	Sulforaphane reduced proliferation in MCF-7 cells and inhibited cyclooxygenase-2 expression in M13SV1 cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	121-157	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-80
17962218-3	2007	We found that the topical application of 5-OH-HxMF can effectively inhibit the transcriptional activation of iNOS and COX-2 mRNA and protein in mouse skin stimulated by TPA.	Tetradecanoylphorbol Acetate	169-172	nitric oxide synthase 2, inducible	Mus musculus	109-113
17962218-4	2007	Pre-treatment with 5-OH-HxMF resulted in the reduction of TPA-induced nuclear translocation of nuclear factor-kappaB (NF-kappaB) subunit and DNA binding by blocking phosphorylation of inhibitor kappaB (IkappaB) alpha and p65 and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	58-61	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-116
17962218-4	2007	Pre-treatment with 5-OH-HxMF resulted in the reduction of TPA-induced nuclear translocation of nuclear factor-kappaB (NF-kappaB) subunit and DNA binding by blocking phosphorylation of inhibitor kappaB (IkappaB) alpha and p65 and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	58-61	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	118-127
17962218-4	2007	Pre-treatment with 5-OH-HxMF resulted in the reduction of TPA-induced nuclear translocation of nuclear factor-kappaB (NF-kappaB) subunit and DNA binding by blocking phosphorylation of inhibitor kappaB (IkappaB) alpha and p65 and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	58-61	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	184-216
17962218-4	2007	Pre-treatment with 5-OH-HxMF resulted in the reduction of TPA-induced nuclear translocation of nuclear factor-kappaB (NF-kappaB) subunit and DNA binding by blocking phosphorylation of inhibitor kappaB (IkappaB) alpha and p65 and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	58-61	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	255-267
17962218-5	2007	In addition, 5-OH-HxMF can inhibit TPA-induced phosphorylation and nuclear translocation of the signal transducer and activator of transcription-3.	Tetradecanoylphorbol Acetate	35-38	signal transducer and activator of transcription 3	Mus musculus	96-146
17962218-6	2007	Moreover, 5-OH-HxMF can suppress TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt, which are upstream of NF-kappaB.	Tetradecanoylphorbol Acetate	33-36	thymoma viral proto-oncogene 1	Mus musculus	173-176
17962218-6	2007	Moreover, 5-OH-HxMF can suppress TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt, which are upstream of NF-kappaB.	Tetradecanoylphorbol Acetate	33-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	200-209
18056199-2	2007	In this study, we investigated whether synthetic induction of c-Fos/AP-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) converts the phenotype of TRAIL-resistant prostate cancer cells to a TRAIL-sensitive phenotype in vitro and in vivo.	Tetradecanoylphorbol Acetate	76-112	TNF superfamily member 10	Homo sapiens	145-150
18056199-2	2007	In this study, we investigated whether synthetic induction of c-Fos/AP-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) converts the phenotype of TRAIL-resistant prostate cancer cells to a TRAIL-sensitive phenotype in vitro and in vivo.	Tetradecanoylphorbol Acetate	114-117	TNF superfamily member 10	Homo sapiens	145-150
18056199-2	2007	In this study, we investigated whether synthetic induction of c-Fos/AP-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) converts the phenotype of TRAIL-resistant prostate cancer cells to a TRAIL-sensitive phenotype in vitro and in vivo.	Tetradecanoylphorbol Acetate	114-117	TNF superfamily member 10	Homo sapiens	188-193
18056199-3	2007	EXPERIMENTAL DESIGN: Low-dose TPA was used to determine whether LNCaP prostate cancer cells could be converted to a TRAIL-sensitive phenotype in in vitro and in vivo studies.	Tetradecanoylphorbol Acetate	30-33	TNF superfamily member 10	Homo sapiens	116-121
18056199-4	2007	We also assessed whether TPA enhancement of TRAIL-induced apoptosis varies between androgen-sensitive and androgen-insensitive prostate cancer cells and evaluated the role of TRAIL receptors, DR4 and DR5, in TPA-enhanced TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	25-28	TNF superfamily member 10	Homo sapiens	44-49
18056199-5	2007	RESULTS: We show that the combination of TRAIL with low-dose TPA has no effect on nonmalignant prostate epithelial cells; however, TPA up-regulates most AP-1 proteins and AP-1 activity, reduces c-FLIP(L), and potentiates TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	131-134	CASP8 and FADD like apoptosis regulator	Homo sapiens	194-200
18056199-5	2007	RESULTS: We show that the combination of TRAIL with low-dose TPA has no effect on nonmalignant prostate epithelial cells; however, TPA up-regulates most AP-1 proteins and AP-1 activity, reduces c-FLIP(L), and potentiates TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	131-134	TNF superfamily member 10	Homo sapiens	221-226
18056199-7	2007	Although TPA enhances the TRAIL-receptor 1 (DR4) level, sensitization of prostate cancer cells seems to be more dependent on TRAIL-receptor 2 (DR5) than TRAIL-receptor 1 levels.	Tetradecanoylphorbol Acetate	9-12	TNF superfamily member 10	Homo sapiens	26-31
18056199-8	2007	In vivo xenograft experiments suggest that TPA elevates the expression of c-Fos and reduces c-FLIP(L).	Tetradecanoylphorbol Acetate	43-46	CASP8 and FADD like apoptosis regulator	Homo sapiens	92-98
17962218-2	2007	Herein, we report the first investigation of the inhibitory effects of 5-OH-HxMF on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	84-120	nitric oxide synthase 2, inducible	Mus musculus	149-180
17962218-2	2007	Herein, we report the first investigation of the inhibitory effects of 5-OH-HxMF on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	84-120	nitric oxide synthase 2, inducible	Mus musculus	182-186
17962218-2	2007	Herein, we report the first investigation of the inhibitory effects of 5-OH-HxMF on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	122-125	nitric oxide synthase 2, inducible	Mus musculus	149-180
17962218-2	2007	Herein, we report the first investigation of the inhibitory effects of 5-OH-HxMF on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	122-125	nitric oxide synthase 2, inducible	Mus musculus	182-186
18056199-10	2007	CONCLUSIONS: TPA, when combined with the proapoptotic agent TRAIL, is effective in changing the phenotype of some TRAIL-resistant prostate cancer cells to a TRAIL-sensitive phenotype.	Tetradecanoylphorbol Acetate	13-16	TNF superfamily member 10	Homo sapiens	114-119
18056199-10	2007	CONCLUSIONS: TPA, when combined with the proapoptotic agent TRAIL, is effective in changing the phenotype of some TRAIL-resistant prostate cancer cells to a TRAIL-sensitive phenotype.	Tetradecanoylphorbol Acetate	13-16	TNF superfamily member 10	Homo sapiens	114-119
18090122-3	2007	Sulforaphane reduced proliferation in MCF-7 cells and inhibited cyclooxygenase-2 expression in M13SV1 cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	159-162	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-80
18090122-5	2007	Sulforaphane upregulates p38 in MCF-7 cells and prevented TPA-reduced phosphorylation of p38 in M13SV1 cells, but activated caspase-7 associated with apoptosis in MCF-7 cells.	Tetradecanoylphorbol Acetate	58-61	mitogen-activated protein kinase 14	Homo sapiens	89-92
17982698-5	2007	MAP kinase p38 was shown to be activated in HNSCC by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	53-84	mitogen-activated protein kinase 14	Homo sapiens	11-14
17982670-7	2007	TPA-induced degradation of IkappaB-alpha was markedly abrogated by treatments with PKC inhibitors, but not by treatments with inhibitors of ERK, p38 MAPK, JNK, or PI-3K.	Tetradecanoylphorbol Acetate	0-3	NFKB inhibitor alpha	Homo sapiens	27-40
17982670-9	2007	These results suggest that TPA induces the expression of B7-DC, -H1, -H2, and -H3 mRNA in K562 cells via activation of PKC, ERK, p38 MAPK, and NF-kappaB.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Homo sapiens	124-127
17982670-0	2007	12-O-tetradecanoyl phorbol 13-acetate induces the expression of B7-DC, -H1, -H2, and -H3 in K562 cells.	Tetradecanoylphorbol Acetate	0-37	programmed cell death 1 ligand 2	Mus musculus	64-69
17982670-3	2007	TPA also induced activation of ERK, p38 mitogen-activated protein kinase (MAPK), JNK, phosphatidylinositol-3-kinase (PI-3K), or nuclear factor (NF)-kappaB.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	31-34
17982670-3	2007	TPA also induced activation of ERK, p38 mitogen-activated protein kinase (MAPK), JNK, phosphatidylinositol-3-kinase (PI-3K), or nuclear factor (NF)-kappaB.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	36-72
17982670-3	2007	TPA also induced activation of ERK, p38 mitogen-activated protein kinase (MAPK), JNK, phosphatidylinositol-3-kinase (PI-3K), or nuclear factor (NF)-kappaB.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	74-78
17982670-3	2007	TPA also induced activation of ERK, p38 mitogen-activated protein kinase (MAPK), JNK, phosphatidylinositol-3-kinase (PI-3K), or nuclear factor (NF)-kappaB.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	81-84
17982670-9	2007	These results suggest that TPA induces the expression of B7-DC, -H1, -H2, and -H3 mRNA in K562 cells via activation of PKC, ERK, p38 MAPK, and NF-kappaB.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 14	Homo sapiens	129-132
17920620-3	2007	The assay was conducted using a human monocytic leukemia cell line, THP-1, treated with either 12-O-tetradecanoylphorbol 13-acetate or cytokines, such as tumor necrosis factor-alpha and interferon-gamma.	Tetradecanoylphorbol Acetate	95-131	GLI family zinc finger 2	Homo sapiens	68-73
17982670-10	2007	Distinctly, the expression of B7-DC mRNA and -H3 mRNA in response to TPA is also PI-3K- and JNK-dependent, respectively.	Tetradecanoylphorbol Acetate	69-72	mitogen-activated protein kinase 8	Homo sapiens	92-95
17982670-3	2007	TPA also induced activation of ERK, p38 mitogen-activated protein kinase (MAPK), JNK, phosphatidylinositol-3-kinase (PI-3K), or nuclear factor (NF)-kappaB.	Tetradecanoylphorbol Acetate	0-3	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	86-115
17982670-3	2007	TPA also induced activation of ERK, p38 mitogen-activated protein kinase (MAPK), JNK, phosphatidylinositol-3-kinase (PI-3K), or nuclear factor (NF)-kappaB.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	128-154
17982670-4	2007	Pre-treatments with protein kinase C (PKC) inhibitors significantly inhibited TPA-induced expression of B7-DC, -H1, -H2, and -H3 mRNA as well as TPA-induced phosphorylation of ERK, p38 MAPK, JNK, and PI-3K.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 1	Homo sapiens	176-179
17982670-4	2007	Pre-treatments with protein kinase C (PKC) inhibitors significantly inhibited TPA-induced expression of B7-DC, -H1, -H2, and -H3 mRNA as well as TPA-induced phosphorylation of ERK, p38 MAPK, JNK, and PI-3K.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 14	Homo sapiens	181-184
17982670-4	2007	Pre-treatments with protein kinase C (PKC) inhibitors significantly inhibited TPA-induced expression of B7-DC, -H1, -H2, and -H3 mRNA as well as TPA-induced phosphorylation of ERK, p38 MAPK, JNK, and PI-3K.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 1	Homo sapiens	185-189
17982670-4	2007	Pre-treatments with protein kinase C (PKC) inhibitors significantly inhibited TPA-induced expression of B7-DC, -H1, -H2, and -H3 mRNA as well as TPA-induced phosphorylation of ERK, p38 MAPK, JNK, and PI-3K.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 8	Homo sapiens	191-194
17982670-4	2007	Pre-treatments with protein kinase C (PKC) inhibitors significantly inhibited TPA-induced expression of B7-DC, -H1, -H2, and -H3 mRNA as well as TPA-induced phosphorylation of ERK, p38 MAPK, JNK, and PI-3K.	Tetradecanoylphorbol Acetate	145-148	mitogen-activated protein kinase 1	Homo sapiens	176-179
17982670-4	2007	Pre-treatments with protein kinase C (PKC) inhibitors significantly inhibited TPA-induced expression of B7-DC, -H1, -H2, and -H3 mRNA as well as TPA-induced phosphorylation of ERK, p38 MAPK, JNK, and PI-3K.	Tetradecanoylphorbol Acetate	145-148	mitogen-activated protein kinase 14	Homo sapiens	181-184
17982670-4	2007	Pre-treatments with protein kinase C (PKC) inhibitors significantly inhibited TPA-induced expression of B7-DC, -H1, -H2, and -H3 mRNA as well as TPA-induced phosphorylation of ERK, p38 MAPK, JNK, and PI-3K.	Tetradecanoylphorbol Acetate	145-148	mitogen-activated protein kinase 1	Homo sapiens	185-189
17982670-4	2007	Pre-treatments with protein kinase C (PKC) inhibitors significantly inhibited TPA-induced expression of B7-DC, -H1, -H2, and -H3 mRNA as well as TPA-induced phosphorylation of ERK, p38 MAPK, JNK, and PI-3K.	Tetradecanoylphorbol Acetate	145-148	mitogen-activated protein kinase 8	Homo sapiens	191-194
17982670-5	2007	TPA-induced expression of B7-DC, -H1, -H2, and -H3 mRNA was abrogated by pre-treatments with inhibitors of ERK and p38 MAPK.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	107-110
17982670-5	2007	TPA-induced expression of B7-DC, -H1, -H2, and -H3 mRNA was abrogated by pre-treatments with inhibitors of ERK and p38 MAPK.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	115-118
17982670-6	2007	However, inhibition of PI-3K and JNK only caused decrease of TPA-induced B7-DC mRNA and B7-H3 mRNA, respectively.	Tetradecanoylphorbol Acetate	61-64	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	23-36
17976640-4	2007	All agonist treatments resulted in S2248 phosphorylation of mTOR and T389 and S421/T424 phosphorylation of S6K1, however only ET-1 and TPA-stimulated mTOR/S6K1 activation was abolished with infection of a dominant negative adenoviral c-Raf (DN-Raf) construct.	Tetradecanoylphorbol Acetate	135-138	mechanistic target of rapamycin kinase	Homo sapiens	150-154
17964599-8	2007	Intriguingly, prior exposure to the adenylyl cyclase activator forskolin (1 microM for 5 min) or the beta-adrenergic agonist isoprenaline (100 nM for 5 min) markedly attenuated ET1-induced PKD activation, but not PMA-induced PKD activation.	Tetradecanoylphorbol Acetate	213-216	endothelin 1	Rattus norvegicus	177-180
18171992-8	2007	In cultured primary keratinocytes, TPA treatment also led to activation of Akt.	Tetradecanoylphorbol Acetate	35-38	thymoma viral proto-oncogene 1	Mus musculus	75-78
17878405-7	2007	Imidaprilat also inhibited THP-1 cell adhesion induced by phorbol 12-myristate 13-acetate (PMA), a potent PKC activator.	Tetradecanoylphorbol Acetate	58-89	proline rich transmembrane protein 2	Homo sapiens	106-109
17878405-7	2007	Imidaprilat also inhibited THP-1 cell adhesion induced by phorbol 12-myristate 13-acetate (PMA), a potent PKC activator.	Tetradecanoylphorbol Acetate	91-94	proline rich transmembrane protein 2	Homo sapiens	106-109
18171992-12	2007	However, combination of EGFR inhibitor and PKC inhibitor completely abrogated TPA-induced activation of Akt.	Tetradecanoylphorbol Acetate	78-81	thymoma viral proto-oncogene 1	Mus musculus	104-107
18171992-9	2007	Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	92-95	thymoma viral proto-oncogene 1	Mus musculus	108-111
18171992-9	2007	Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	92-95	thymoma viral proto-oncogene 1	Mus musculus	258-261
17920036-0	2007	Regulation of p21Waf1 expression and TNFalpha biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: involvement of JNK and ERK pathways.	Tetradecanoylphorbol Acetate	88-91	tumor necrosis factor	Homo sapiens	37-45
17920036-0	2007	Regulation of p21Waf1 expression and TNFalpha biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: involvement of JNK and ERK pathways.	Tetradecanoylphorbol Acetate	88-91	GLI family zinc finger 2	Homo sapiens	100-104
17920036-4	2007	We observed an increase of p21Waf1 expression and TNFalpha biosynthesis in the THP1 monocyte/macrophage cell line treated with PMA.	Tetradecanoylphorbol Acetate	127-130	tumor necrosis factor	Homo sapiens	50-58
17664349-6	2007	WAVE2(-/-) MKs exhibited a defect in peripheral lamellipodia on fibrinogen even with phorbol 12-myristate 13-acetate (PMA) costimulation, indicating a requirement of WAVE2 for integrin alpha(IIb)beta(3)-mediated full spreading.	Tetradecanoylphorbol Acetate	85-116	WASP family, member 2	Mus musculus	0-5
17920036-4	2007	We observed an increase of p21Waf1 expression and TNFalpha biosynthesis in the THP1 monocyte/macrophage cell line treated with PMA.	Tetradecanoylphorbol Acetate	127-130	GLI family zinc finger 2	Homo sapiens	79-83
17920036-5	2007	Treatment of THP1 cultures with NAC prior to adding PMA abrogates the expression of p21Waf1 mRNA and decreases the level of TNFalpha whereas GSH depletion by BSO enhances the levels of TNFalpha with minor effects on p21Waf1 expression.	Tetradecanoylphorbol Acetate	52-55	tumor necrosis factor	Homo sapiens	124-132
17944529-4	2007	Here we report that 3,3",4",5,5",7-hexahydroxyflavone (myricetin), one of the major flavonols in red wine, inhibits 12-O-tetradecanoylphorbol-13-acetate (phorbol ester)-induced COX-2 expression in JB6 P+ mouse epidermal (JB6 P+) cells by suppressing activation of nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	116-152	prostaglandin-endoperoxide synthase 2	Homo sapiens	177-182
17702895-5	2007	Importantly, silencing of the Rap1 guanine exchange factor CalDAG-GEFI inhibited SDF-1alpha- and phorbol 12-myristate 13-acetate (PMA)-induced adhesion to ICAM-1 while having no effect on adhesion to VCAM-1.	Tetradecanoylphorbol Acetate	130-133	vascular cell adhesion molecule 1	Homo sapiens	200-206
17944529-4	2007	Here we report that 3,3",4",5,5",7-hexahydroxyflavone (myricetin), one of the major flavonols in red wine, inhibits 12-O-tetradecanoylphorbol-13-acetate (phorbol ester)-induced COX-2 expression in JB6 P+ mouse epidermal (JB6 P+) cells by suppressing activation of nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	116-152	nuclear factor kappa B subunit 1	Homo sapiens	264-286
17944529-4	2007	Here we report that 3,3",4",5,5",7-hexahydroxyflavone (myricetin), one of the major flavonols in red wine, inhibits 12-O-tetradecanoylphorbol-13-acetate (phorbol ester)-induced COX-2 expression in JB6 P+ mouse epidermal (JB6 P+) cells by suppressing activation of nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	116-152	nuclear factor kappa B subunit 1	Homo sapiens	288-297
17600309-1	2007	We previously showed that the MUC5B gene expression was elevated by phorbol 12-myristate 13-acetate (PMA) through an epidermal growth factor receptor-independent Ras/MEKK1/JNK and P38 signaling-based transcriptional mechanism.	Tetradecanoylphorbol Acetate	68-99	epidermal growth factor receptor	Homo sapiens	117-149
17907296-2	2007	METHODS: The ARIP2 mRNA expression kinetics in Hepal-6 cells was detected by RT-PCR, and its regulation factors were analyzed by treatment with signal transduction activators such as phorbol 12-myristate 13-acetate (PMA), forskolin and A23187.	Tetradecanoylphorbol Acetate	216-219	synaptojanin 2 binding protein	Mus musculus	13-18
17907296-5	2007	The ARIP2 mRNA expression was increased after stimulated with signal transduction activators such as PMA and forskolin in Hepal-6 cells, whereas decreased after treatment with A23187 (25.3% +/- 5.7% vs 48.1% +/- 3.6%, P &lt; 0.01).	Tetradecanoylphorbol Acetate	101-104	synaptojanin 2 binding protein	Mus musculus	4-9
17600309-1	2007	We previously showed that the MUC5B gene expression was elevated by phorbol 12-myristate 13-acetate (PMA) through an epidermal growth factor receptor-independent Ras/MEKK1/JNK and P38 signaling-based transcriptional mechanism.	Tetradecanoylphorbol Acetate	68-99	mitogen-activated protein kinase 8	Homo sapiens	172-175
17600309-1	2007	We previously showed that the MUC5B gene expression was elevated by phorbol 12-myristate 13-acetate (PMA) through an epidermal growth factor receptor-independent Ras/MEKK1/JNK and P38 signaling-based transcriptional mechanism.	Tetradecanoylphorbol Acetate	68-99	mitogen-activated protein kinase 14	Homo sapiens	180-183
17600309-1	2007	We previously showed that the MUC5B gene expression was elevated by phorbol 12-myristate 13-acetate (PMA) through an epidermal growth factor receptor-independent Ras/MEKK1/JNK and P38 signaling-based transcriptional mechanism.	Tetradecanoylphorbol Acetate	101-104	epidermal growth factor receptor	Homo sapiens	117-149
17600309-1	2007	We previously showed that the MUC5B gene expression was elevated by phorbol 12-myristate 13-acetate (PMA) through an epidermal growth factor receptor-independent Ras/MEKK1/JNK and P38 signaling-based transcriptional mechanism.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase 8	Homo sapiens	172-175
17600309-1	2007	We previously showed that the MUC5B gene expression was elevated by phorbol 12-myristate 13-acetate (PMA) through an epidermal growth factor receptor-independent Ras/MEKK1/JNK and P38 signaling-based transcriptional mechanism.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase 14	Homo sapiens	180-183
17728253-5	2007	The C1b domain mediates phorbol 12-myristate 13-acetate-induced translocation and activation of DKF-2.	Tetradecanoylphorbol Acetate	24-55	Serine/threonine-protein kinase dkf-2	Caenorhabditis elegans	96-101
18087815-5	2007	It was also found that DDMP modulated tumor necrosis factor-alpha (TNF-alpha) and tetradeanoyl phorbol acetate (TPA)-induced NF-kappaB transcriptional and DNA binding activity.	Tetradecanoylphorbol Acetate	112-115	nuclear factor kappa B subunit 1	Homo sapiens	125-134
17974959-7	2007	In primary keratinocytes isolated from K5.RasGRP1 mice, TPA stimulation induced higher levels of Ras activation compared with the levels measured in the wild-type cells, indicating that constitutive overexpression of RasGRP1 in epidermal cells leads to elevated biochemical activation of endogenous Ras in response to TPA.	Tetradecanoylphorbol Acetate	56-59	RAS guanyl releasing protein 1	Mus musculus	42-49
17974959-7	2007	In primary keratinocytes isolated from K5.RasGRP1 mice, TPA stimulation induced higher levels of Ras activation compared with the levels measured in the wild-type cells, indicating that constitutive overexpression of RasGRP1 in epidermal cells leads to elevated biochemical activation of endogenous Ras in response to TPA.	Tetradecanoylphorbol Acetate	56-59	RAS guanyl releasing protein 1	Mus musculus	217-224
17974959-7	2007	In primary keratinocytes isolated from K5.RasGRP1 mice, TPA stimulation induced higher levels of Ras activation compared with the levels measured in the wild-type cells, indicating that constitutive overexpression of RasGRP1 in epidermal cells leads to elevated biochemical activation of endogenous Ras in response to TPA.	Tetradecanoylphorbol Acetate	318-321	RAS guanyl releasing protein 1	Mus musculus	217-224
17541586-1	2007	PURPOSE: In this study, we evaluated the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced acute and chronic inflammation in living mice by PET imaging of TNF-alpha and integrin alpha(v)beta(3) expression.	Tetradecanoylphorbol Acetate	41-78	tumor necrosis factor	Mus musculus	157-166
17541586-1	2007	PURPOSE: In this study, we evaluated the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced acute and chronic inflammation in living mice by PET imaging of TNF-alpha and integrin alpha(v)beta(3) expression.	Tetradecanoylphorbol Acetate	80-83	tumor necrosis factor	Mus musculus	157-166
17541586-5	2007	RESULTS: The ear thickness increased significantly and the TNF-alpha level more than tripled after a single TPA challenge.	Tetradecanoylphorbol Acetate	108-111	tumor necrosis factor	Mus musculus	59-68
17541586-7	2007	Repeated TPA challenges caused TPA-specific chronic inflammation and reduced (64)Cu-DOTA-etanercept uptake due to lowered TNF-alpha expression.	Tetradecanoylphorbol Acetate	9-12	tumor necrosis factor	Mus musculus	122-131
18224287-1	2007	OBJECTIVE: The participation of sensory neurons and transient receptor potential vanilloid 1 (TRPV1) receptors in phorbol 12-myristate 13-acetate (PMA)-induced nerve-sensitizing effect was examined.	Tetradecanoylphorbol Acetate	147-150	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	94-99
17434721-6	2007	Stimulation of interleukin-2 transcriptional activity with phorbol-12-myristate-13-acetate and phytohemagglutinin caused a rapid depletion of K12Bio H4 in the gene promoter.	Tetradecanoylphorbol Acetate	59-90	interleukin 2	Homo sapiens	15-28
17617058-8	2007	In cells, the IGF-1-stimulated phosphorylations, and certain EGF-stimulated phosphorylations, were inhibited by PI3K (phosphoinositide 3-kinase) inhibitors, whereas the RSK inhibitor BI-D1870 inhibited the PMA-induced phosphorylations.	Tetradecanoylphorbol Acetate	206-209	insulin like growth factor 1	Homo sapiens	14-19
17546596-7	2007	T-cells were further characterized for IL- 2 and IFN-gamma production induced by PMA/Ionomycin.	Tetradecanoylphorbol Acetate	81-84	interferon gamma	Homo sapiens	49-58
17825823-5	2007	S1P activated p190Rho GTPase activation protein (GAP) only in the presence of PMA, suggesting an inhibitory effect of S1P and PMA to suppress RhoA.	Tetradecanoylphorbol Acetate	126-129	ras homolog family member A	Homo sapiens	142-146
17407144-2	2007	Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) and can then be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL).	Tetradecanoylphorbol Acetate	80-105	GLI family zinc finger 2	Homo sapiens	6-11
17786281-3	2007	These effects were blocked by a tyrosine kinase inhibitor (PP2) or Src small interfering RNA (siRNA), indicating that Src was involved in the PMA-induced activation of Cas/Crk/Rac1 signaling pathway.	Tetradecanoylphorbol Acetate	142-145	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	67-70
17786281-3	2007	These effects were blocked by a tyrosine kinase inhibitor (PP2) or Src small interfering RNA (siRNA), indicating that Src was involved in the PMA-induced activation of Cas/Crk/Rac1 signaling pathway.	Tetradecanoylphorbol Acetate	142-145	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	118-121
17786281-3	2007	These effects were blocked by a tyrosine kinase inhibitor (PP2) or Src small interfering RNA (siRNA), indicating that Src was involved in the PMA-induced activation of Cas/Crk/Rac1 signaling pathway.	Tetradecanoylphorbol Acetate	142-145	CRK proto-oncogene, adaptor protein	Homo sapiens	172-175
17786281-8	2007	We demonstrated that PMA induced phosphorylation of Crk, and this phosphorylation was blocked by PP2 or Src siRNA.	Tetradecanoylphorbol Acetate	21-24	CRK proto-oncogene, adaptor protein	Homo sapiens	52-55
17786281-8	2007	We demonstrated that PMA induced phosphorylation of Crk, and this phosphorylation was blocked by PP2 or Src siRNA.	Tetradecanoylphorbol Acetate	21-24	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	104-107
17786281-10	2007	We propose that PMA-induced migration was dependent on activation of PKC/Src/Cas/Crk/Rac1 signaling pathway via modulating cytoskeletal reorganization during glioblastoma cell migration.	Tetradecanoylphorbol Acetate	16-19	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	73-76
17786281-10	2007	We propose that PMA-induced migration was dependent on activation of PKC/Src/Cas/Crk/Rac1 signaling pathway via modulating cytoskeletal reorganization during glioblastoma cell migration.	Tetradecanoylphorbol Acetate	16-19	CRK proto-oncogene, adaptor protein	Homo sapiens	81-84
17786281-0	2007	Src regulates phorbol 12-myristate 13-acetate-activated PKC-induced migration via Cas/Crk/Rac1 signaling pathway in glioblastoma cells.	Tetradecanoylphorbol Acetate	14-45	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
17786281-0	2007	Src regulates phorbol 12-myristate 13-acetate-activated PKC-induced migration via Cas/Crk/Rac1 signaling pathway in glioblastoma cells.	Tetradecanoylphorbol Acetate	14-45	CRK proto-oncogene, adaptor protein	Homo sapiens	86-89
17786281-1	2007	In this study, we demonstrate that phorbol 12-myristate 13-acetate (PMA)-activated protein kinase C (PKC) induced migration in A172 glioblastoma cells via Src.	Tetradecanoylphorbol Acetate	35-66	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	155-158
17786281-1	2007	In this study, we demonstrate that phorbol 12-myristate 13-acetate (PMA)-activated protein kinase C (PKC) induced migration in A172 glioblastoma cells via Src.	Tetradecanoylphorbol Acetate	68-71	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	155-158
17786281-2	2007	PMA treatment induced tyrosine phosphorylation of Crk-associated substrate (Cas) and formation of a complex with Crk, followed by Rac1 activation, a downstream effector of Cas/Crk complex.	Tetradecanoylphorbol Acetate	0-3	CRK proto-oncogene, adaptor protein	Homo sapiens	50-53
17786281-2	2007	PMA treatment induced tyrosine phosphorylation of Crk-associated substrate (Cas) and formation of a complex with Crk, followed by Rac1 activation, a downstream effector of Cas/Crk complex.	Tetradecanoylphorbol Acetate	0-3	CRK proto-oncogene, adaptor protein	Homo sapiens	113-116
17407144-2	2007	Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) and can then be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL).	Tetradecanoylphorbol Acetate	107-110	GLI family zinc finger 2	Homo sapiens	6-11
17407158-9	2007	However, phorbol 12-myristate 13-acetate (PMA), a selective PKC activator induced MGP mRNA expression through activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	9-40	mitogen-activated protein kinase 1	Mus musculus	124-161
17407158-9	2007	However, phorbol 12-myristate 13-acetate (PMA), a selective PKC activator induced MGP mRNA expression through activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	9-40	mitogen-activated protein kinase 1	Mus musculus	163-166
17407158-9	2007	However, phorbol 12-myristate 13-acetate (PMA), a selective PKC activator induced MGP mRNA expression through activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 1	Mus musculus	124-161
17407158-9	2007	However, phorbol 12-myristate 13-acetate (PMA), a selective PKC activator induced MGP mRNA expression through activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 1	Mus musculus	163-166
17803520-6	2007	Activation of PKC by incubation with triphorbol ester acetate (TPA) blocks the inhibitory effect of melatonin on Akt and NF-kappaB activity.	Tetradecanoylphorbol Acetate	63-66	AKT serine/threonine kinase 1	Homo sapiens	113-116
17678893-5	2007	Analyses using PKC inhibitors and siRNA suggest that PKCepsilon, an isoform typically expressed in ovarian cancer cells, may be important in the TPA-mediated claudin-4 phosphorylation and weakening of the TJs.	Tetradecanoylphorbol Acetate	145-148	claudin 4	Homo sapiens	158-167
17573821-5	2007	Tumor necrosis factor alpha (TNFalpha) secretion was significantly inhibited in both primary microglia and THP-1 cells differentiated for 72 h in the presence of PMA to induce a macrophage-like phenotype.	Tetradecanoylphorbol Acetate	162-165	tumor necrosis factor	Homo sapiens	0-27
17573821-5	2007	Tumor necrosis factor alpha (TNFalpha) secretion was significantly inhibited in both primary microglia and THP-1 cells differentiated for 72 h in the presence of PMA to induce a macrophage-like phenotype.	Tetradecanoylphorbol Acetate	162-165	tumor necrosis factor	Homo sapiens	29-37
17573821-5	2007	Tumor necrosis factor alpha (TNFalpha) secretion was significantly inhibited in both primary microglia and THP-1 cells differentiated for 72 h in the presence of PMA to induce a macrophage-like phenotype.	Tetradecanoylphorbol Acetate	162-165	GLI family zinc finger 2	Homo sapiens	107-112
17970088-8	2007	Triptolide suppressed the PMA-induced activation of NF-kappaB but not Erk-1/2 and JNKI The inhibitory effect of triptolide on the activation of NF-kappaB was confirmed by an electrophoretic mobility shift assay and NF-kappaB dependent transcription studies.	Tetradecanoylphorbol Acetate	26-29	nuclear factor kappa B subunit 1	Homo sapiens	52-61
17616647-4	2007	nPKCdelta in SPOC1 cells was tyrosine phosphorylated by exposure to purinergic agonist (ATPgammaS) or PMA, actions that were blocked by the Src kinase inhibitor, PP1.	Tetradecanoylphorbol Acetate	102-105	neuropeptide Y receptor Y4	Rattus norvegicus	162-165
17638546-5	2007	Here we demonstrate that hypoxia-reoxygenation and agents that activate protein kinase C, including calcium ionophore, phorbol 12-myristate 13-acetate, and okadaic acid, also induce Bnip3.	Tetradecanoylphorbol Acetate	119-150	BCL2 interacting protein 3	Homo sapiens	182-187
17970088-8	2007	Triptolide suppressed the PMA-induced activation of NF-kappaB but not Erk-1/2 and JNKI The inhibitory effect of triptolide on the activation of NF-kappaB was confirmed by an electrophoretic mobility shift assay and NF-kappaB dependent transcription studies.	Tetradecanoylphorbol Acetate	26-29	nuclear factor kappa B subunit 1	Homo sapiens	144-153
17970088-8	2007	Triptolide suppressed the PMA-induced activation of NF-kappaB but not Erk-1/2 and JNKI The inhibitory effect of triptolide on the activation of NF-kappaB was confirmed by an electrophoretic mobility shift assay and NF-kappaB dependent transcription studies.	Tetradecanoylphorbol Acetate	26-29	nuclear factor kappa B subunit 1	Homo sapiens	144-153
17640620-1	2007	We investigated the mechanism of phorbol 12-myristate 13-acetate (PMA)-induced migration of glioblastoma cells focusing on the p38 mitogen-activated protein kinase (MAPK)/heat shock protein 27 (Hsp27) pathway.	Tetradecanoylphorbol Acetate	33-64	mitogen-activated protein kinase 14	Homo sapiens	127-163
17689141-1	2007	Recently, we have shown that protein kinase C (PKC) activated by phorbol 12-myristate 13-acetate (PMA) attenuates the beta1-adrenergic receptor (beta1-AR)-mediated lipolysis in rat adipocytes.	Tetradecanoylphorbol Acetate	65-96	adrenoceptor beta 1	Rattus norvegicus	118-143
17689141-1	2007	Recently, we have shown that protein kinase C (PKC) activated by phorbol 12-myristate 13-acetate (PMA) attenuates the beta1-adrenergic receptor (beta1-AR)-mediated lipolysis in rat adipocytes.	Tetradecanoylphorbol Acetate	65-96	adrenoceptor beta 1	Rattus norvegicus	145-153
17689141-1	2007	Recently, we have shown that protein kinase C (PKC) activated by phorbol 12-myristate 13-acetate (PMA) attenuates the beta1-adrenergic receptor (beta1-AR)-mediated lipolysis in rat adipocytes.	Tetradecanoylphorbol Acetate	98-101	adrenoceptor beta 1	Rattus norvegicus	118-143
17689141-1	2007	Recently, we have shown that protein kinase C (PKC) activated by phorbol 12-myristate 13-acetate (PMA) attenuates the beta1-adrenergic receptor (beta1-AR)-mediated lipolysis in rat adipocytes.	Tetradecanoylphorbol Acetate	98-101	adrenoceptor beta 1	Rattus norvegicus	145-153
17640620-1	2007	We investigated the mechanism of phorbol 12-myristate 13-acetate (PMA)-induced migration of glioblastoma cells focusing on the p38 mitogen-activated protein kinase (MAPK)/heat shock protein 27 (Hsp27) pathway.	Tetradecanoylphorbol Acetate	66-69	mitogen-activated protein kinase 14	Homo sapiens	127-163
17693661-9	2007	Myricetin strongly inhibited MEK1 kinase activity and suppressed TPA- or EGF-induced phosphorylation of extracellular signal-regulated kinase (ERK) or p90 ribosomal S6 kinase, downstream targets of MEK.	Tetradecanoylphorbol Acetate	65-68	mitogen-activated protein kinase 1	Homo sapiens	104-141
17320950-8	2007	With a direct in cellulo approach and an indirect in cellulo back-phosphorylation approach we showed that phorbol-12-myristate-13-acetate (PMA) causes the phosphorylation of IP3R-3 in intact RINm5F cells.	Tetradecanoylphorbol Acetate	106-137	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	174-180
17320950-8	2007	With a direct in cellulo approach and an indirect in cellulo back-phosphorylation approach we showed that phorbol-12-myristate-13-acetate (PMA) causes the phosphorylation of IP3R-3 in intact RINm5F cells.	Tetradecanoylphorbol Acetate	139-142	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	174-180
17693661-9	2007	Myricetin strongly inhibited MEK1 kinase activity and suppressed TPA- or EGF-induced phosphorylation of extracellular signal-regulated kinase (ERK) or p90 ribosomal S6 kinase, downstream targets of MEK.	Tetradecanoylphorbol Acetate	65-68	mitogen-activated protein kinase 1	Homo sapiens	143-146
17696950-4	2007	Following stimulation with PMA plus ionomycin, a reduced percentage of CD40L expression in T lymphocytes and a diminished expression of CD40 molecules in neutrophils were observed on leukocytes from these patients.	Tetradecanoylphorbol Acetate	27-30	CD40 ligand	Homo sapiens	71-76
18062235-6	2007	COS also inhibited the expression of TPA-induced COX-2 protein in HT-29 cells.	Tetradecanoylphorbol Acetate	37-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-54
17582004-1	2007	The p12(I) protein of human T-cell leukemia/lymphoma virus type 1 (HTLV-1) is a small oncoprotein that increases calcium release following protein kinase C activation by phorbol myristate acetate, and importantly, this effect is linker for activation of T cells (LAT) independent.	Tetradecanoylphorbol Acetate	170-195	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	4-7
17681786-3	2007	In this study, we demonstrated that various inflammatory agents, including lipopolysaccharide, 12-o-tetradecanoylphorbol-13-acetate, hydrogen peroxide, okadaic acid and ceramide, were able to induce IL-1beta and TNF-alpha productions in human lung epithelial cells (A-549), fibroblasts (HFL1), and lymphoma cells (U-937).	Tetradecanoylphorbol Acetate	95-131	interleukin 1 beta	Homo sapiens	199-207
17681786-3	2007	In this study, we demonstrated that various inflammatory agents, including lipopolysaccharide, 12-o-tetradecanoylphorbol-13-acetate, hydrogen peroxide, okadaic acid and ceramide, were able to induce IL-1beta and TNF-alpha productions in human lung epithelial cells (A-549), fibroblasts (HFL1), and lymphoma cells (U-937).	Tetradecanoylphorbol Acetate	95-131	tumor necrosis factor	Homo sapiens	212-221
17536008-9	2007	A continuous interaction with the actin-binding protein 280 (filamin A), which was previously known to interact with D(3)R, is required for PMA-induced D(3)R sequestration.	Tetradecanoylphorbol Acetate	140-143	filamin A	Homo sapiens	34-59
17536008-9	2007	A continuous interaction with the actin-binding protein 280 (filamin A), which was previously known to interact with D(3)R, is required for PMA-induced D(3)R sequestration.	Tetradecanoylphorbol Acetate	140-143	filamin A	Homo sapiens	61-70
17846509-4	2007	The suppression of mesenchymal cell proliferation induced by TGF-beta 3 and ADAM 10 morpholino antisense oligonucleotides was reversed by activation of ADAM 10 with phorbol 12-myristate 13-acetate (PMA) or knockdown of Notch-1 with siRNA.	Tetradecanoylphorbol Acetate	165-196	transforming growth factor beta 3	Gallus gallus	61-71
17699780-9	2007	EGF and TPA-stimulated Ser9 phosphorylation was mediated by phosphoinositide-3-kinase (PI3K)/Akt and protein kinase C (PKC) pathways.	Tetradecanoylphorbol Acetate	8-11	AKT serine/threonine kinase 1	Homo sapiens	93-96
17556653-3	2007	METHODS AND RESULTS: The effect of IFNgamma on COX-2 expression was evaluated in several types of human cells stimulated with phorbol 12-myristate 13-acetate (PMA), interleukin (IL)-1beta, or tumor necrosis factor (TNF) alpha.	Tetradecanoylphorbol Acetate	126-157	interferon gamma	Homo sapiens	35-43
17556653-3	2007	METHODS AND RESULTS: The effect of IFNgamma on COX-2 expression was evaluated in several types of human cells stimulated with phorbol 12-myristate 13-acetate (PMA), interleukin (IL)-1beta, or tumor necrosis factor (TNF) alpha.	Tetradecanoylphorbol Acetate	126-157	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52
17556653-3	2007	METHODS AND RESULTS: The effect of IFNgamma on COX-2 expression was evaluated in several types of human cells stimulated with phorbol 12-myristate 13-acetate (PMA), interleukin (IL)-1beta, or tumor necrosis factor (TNF) alpha.	Tetradecanoylphorbol Acetate	159-162	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52
17286201-0	2007	PI 3-K signaling pathway suppresses PMA-induced expression of p21WAF1/Cip1 in human leukemia cells.	Tetradecanoylphorbol Acetate	36-39	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-74
17120040-6	2007	Frequencies of CD3(+) and CD4(+) producing IL-2, IL-4, IFN-gamma, and TNF-alpha after in vitro stimulation with phorbol-12-myristate 13-acetate (PMA) + ionomycin were comparable in the AD and control groups.	Tetradecanoylphorbol Acetate	112-143	CD4 molecule	Homo sapiens	26-29
17120040-6	2007	Frequencies of CD3(+) and CD4(+) producing IL-2, IL-4, IFN-gamma, and TNF-alpha after in vitro stimulation with phorbol-12-myristate 13-acetate (PMA) + ionomycin were comparable in the AD and control groups.	Tetradecanoylphorbol Acetate	145-148	tumor necrosis factor	Homo sapiens	70-79
17120040-7	2007	In response to PMA/ionomycin, children with AD and asthma symptoms had a significantly lower percentage of CD3(+) T cells producing TNF-alpha.	Tetradecanoylphorbol Acetate	15-18	tumor necrosis factor	Homo sapiens	132-141
17443671-7	2007	Under the proliferation-inducing conditions (TPA-free), parental or Nef-inactive cells showed modest ERK activation following M-CSF stimulation, whereas Nef-active cells showed an earlier and transient ERK activation, despite a decrease in their proliferation rate.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase 1	Homo sapiens	101-104
17385009-3	2007	Six-hour exposure of human neuroblastoma SK-N-SH cell to a PKC activator phorbol 12-myristate 13-acetate (PMA) decreased the activity of NTE, and this effect was blocked by the PKC inhibitor staurosporine.	Tetradecanoylphorbol Acetate	73-104	patatin like phospholipase domain containing 6	Homo sapiens	137-140
17385009-3	2007	Six-hour exposure of human neuroblastoma SK-N-SH cell to a PKC activator phorbol 12-myristate 13-acetate (PMA) decreased the activity of NTE, and this effect was blocked by the PKC inhibitor staurosporine.	Tetradecanoylphorbol Acetate	106-109	patatin like phospholipase domain containing 6	Homo sapiens	137-140
17385009-7	2007	Together, these findings suggest that stimulation with PMA reduces the expression of NTE mRNA levels but does not affect the exogenous promoter-driven NTE expression in mammalian cells.	Tetradecanoylphorbol Acetate	55-58	patatin like phospholipase domain containing 6	Homo sapiens	85-88
17286201-6	2007	The level of PMA-induced p21WAF1/Cip1 protein expression was lower in NB4 cells overexpressing wild type protein kinase C zeta (PKC zeta) compared to those transfected with empty vector or with kinase inactive PKC zeta.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	33-37
17286201-8	2007	We demonstrate that PI 3-K signaling pathway suppresses PMA-induced expression of p21WAF1/Cip1 in human leukemia cells, and that this effect is partly mediated by PKC zeta.	Tetradecanoylphorbol Acetate	56-59	cyclin dependent kinase inhibitor 1A	Homo sapiens	90-94
17466270-5	2007	This increased NCX reversal was attenuated by SKF-96365, an inhibitor of non-selective cation channels, and by activation of protein kinase C with phorbol ester 12-tetradecanoylphorbol-13 acetate.	Tetradecanoylphorbol Acetate	161-195	solute carrier family 8 member A1	Rattus norvegicus	15-18
17538947-4	2007	It was further shown the Raf/Mek/Erk branch of mitogen-activated protein (MAP) kinase pathway contains a disproportionate number of oppositely regulated genes, thereby implicating it as one of the key pathways involved in tumor promotion by TPA, that is blocked by ATRA.	Tetradecanoylphorbol Acetate	241-244	zinc fingers and homeoboxes 2	Mus musculus	25-28
17538947-4	2007	It was further shown the Raf/Mek/Erk branch of mitogen-activated protein (MAP) kinase pathway contains a disproportionate number of oppositely regulated genes, thereby implicating it as one of the key pathways involved in tumor promotion by TPA, that is blocked by ATRA.	Tetradecanoylphorbol Acetate	241-244	mitogen-activated protein kinase 1	Mus musculus	33-36
17583567-7	2007	PKCepsilon overexpression increases Stat3 activation after either TPA treatment or UVR exposure.	Tetradecanoylphorbol Acetate	66-69	signal transducer and activator of transcription 3	Mus musculus	36-41
17531200-5	2007	Cabin1 (701-900) blocked both CN-mediated dephosphorylation and nuclear import of NFAT and thus inhibited IL-2 production in response to PMA/ionomycin stimulation.	Tetradecanoylphorbol Acetate	137-140	calcineurin binding protein 1	Mus musculus	0-6
17504762-3	2007	In MCF-7 human breast cancer cells, the action of the PKC activator 4beta-phorbol-12-myristate-13-acetate (PMA) evokes ceramide formation, which in turn prevents PKCalpha/betaII translocation to the pericentrion.	Tetradecanoylphorbol Acetate	68-105	protein kinase C alpha	Homo sapiens	54-57
17504762-3	2007	In MCF-7 human breast cancer cells, the action of the PKC activator 4beta-phorbol-12-myristate-13-acetate (PMA) evokes ceramide formation, which in turn prevents PKCalpha/betaII translocation to the pericentrion.	Tetradecanoylphorbol Acetate	68-105	protein kinase C alpha	Homo sapiens	162-177
17504762-3	2007	In MCF-7 human breast cancer cells, the action of the PKC activator 4beta-phorbol-12-myristate-13-acetate (PMA) evokes ceramide formation, which in turn prevents PKCalpha/betaII translocation to the pericentrion.	Tetradecanoylphorbol Acetate	107-110	protein kinase C alpha	Homo sapiens	54-57
17504762-3	2007	In MCF-7 human breast cancer cells, the action of the PKC activator 4beta-phorbol-12-myristate-13-acetate (PMA) evokes ceramide formation, which in turn prevents PKCalpha/betaII translocation to the pericentrion.	Tetradecanoylphorbol Acetate	107-110	protein kinase C alpha	Homo sapiens	162-177
17431791-4	2007	In cells treated with 12-O-tetradecanoylphorbol 13-acetate, the levels of both p21(WAF1/CIP1) and its (146)Ser-phosphorylated form increased significantly.	Tetradecanoylphorbol Acetate	22-58	cyclin dependent kinase inhibitor 1A	Homo sapiens	79-82
17431791-4	2007	In cells treated with 12-O-tetradecanoylphorbol 13-acetate, the levels of both p21(WAF1/CIP1) and its (146)Ser-phosphorylated form increased significantly.	Tetradecanoylphorbol Acetate	22-58	cyclin dependent kinase inhibitor 1A	Homo sapiens	83-87
17431791-4	2007	In cells treated with 12-O-tetradecanoylphorbol 13-acetate, the levels of both p21(WAF1/CIP1) and its (146)Ser-phosphorylated form increased significantly.	Tetradecanoylphorbol Acetate	22-58	cyclin dependent kinase inhibitor 1A	Homo sapiens	88-92
17372274-7	2007	Humulone blunted TPA-induced activation of inhibitory kappaB (IkappaB) kinase (IKK) in mouse skin, which accounts for its suppression of phosphorylation and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	17-20	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	183-195
17446183-6	2007	Kinetic studies of wild-type ovine FSHBLuc in LbetaT2 cells showed continuous induction by activin (4-fold) over 20 h. Most of this induction (78%) was blocked, beginning at 6 h. cAMP response element binding protein (CREB) was implicated in this inhibition because overexpression of its constitutively active mutant mimicked GnRH, and its inhibitor (inducible cAMP early repressor isoform II) reversed the inhibition caused by GnRH, forskolin, or PMA.	Tetradecanoylphorbol Acetate	448-451	cAMP responsive element binding protein 1	Mus musculus	179-216
17446183-7	2007	In addition, GnRH, forskolin, or PMA increased the expression of a CREB-responsive reporter gene, 6xCRE-37PRL-Luc.	Tetradecanoylphorbol Acetate	33-36	cAMP responsive element binding protein 1	Mus musculus	67-71
17638900-7	2007	Temozolomide also inhibits NF-kappaB activated by inducers other than TNFalpha, including lipopolysaccharide, doxorubicin, and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	127-158	nuclear factor kappa B subunit 1	Homo sapiens	27-36
17573185-9	2007	There was an increase in SNARE complex formation in islets stimulated with prolactin, 22 mM glucose, 40 mM K(+), 200 microM carbachol and 1 microM PMA.	Tetradecanoylphorbol Acetate	147-150	prolactin	Rattus norvegicus	75-84
17428891-7	2007	An exposure to 100 nM PMA, a potent PKC activator, inhibited the pinacidil-activated currents, and abolished the channel inhibition by AVP.	Tetradecanoylphorbol Acetate	22-25	proline rich transmembrane protein 2	Homo sapiens	36-39
17428891-7	2007	An exposure to 100 nM PMA, a potent PKC activator, inhibited the pinacidil-activated currents, and abolished the channel inhibition by AVP.	Tetradecanoylphorbol Acetate	22-25	arginine vasopressin	Homo sapiens	135-138
17609508-4	2007	In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-6, and IL-8 secretion in human mast cells.	Tetradecanoylphorbol Acetate	29-60	interleukin 6	Homo sapiens	118-122
17468105-7	2007	In addition, we have found that the p38 mitogen-activated protein kinase is required for BRG1 recruitment in TPA-mediated myogenin induction.	Tetradecanoylphorbol Acetate	109-112	mitogen-activated protein kinase 14	Homo sapiens	36-39
17468105-8	2007	We propose that there are two distinct activation steps for the induction of myogenin in TPA-induced early differentiation of RD cells: 1) an early step that requires PCAF activity to acetylate core histones and MyoD to initiate myogenin gene expression, and 2) a later step that requires p38-dependent activity of the SWI/SNF remodeling complex to provide an open conformation for the induction of myogenin.	Tetradecanoylphorbol Acetate	89-92	myogenic differentiation 1	Homo sapiens	212-216
17468105-8	2007	We propose that there are two distinct activation steps for the induction of myogenin in TPA-induced early differentiation of RD cells: 1) an early step that requires PCAF activity to acetylate core histones and MyoD to initiate myogenin gene expression, and 2) a later step that requires p38-dependent activity of the SWI/SNF remodeling complex to provide an open conformation for the induction of myogenin.	Tetradecanoylphorbol Acetate	89-92	mitogen-activated protein kinase 14	Homo sapiens	289-292
17433258-8	2007	All peptides tested were effective at preventing IL-8 release from phorbol 12-myristate 13-acetate (PMA)/copper-stimulated human umbilical vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	67-98	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
17293488-5	2007	We report here that PKC inhibition attenuated pressure-induced constriction of cerebral vessels and that stimulation of PKC activity with phorbol 12-myristate 13-acetate (PMA) enhanced the development of myogenic tone.	Tetradecanoylphorbol Acetate	138-169	proline rich transmembrane protein 2	Homo sapiens	120-123
17293488-5	2007	We report here that PKC inhibition attenuated pressure-induced constriction of cerebral vessels and that stimulation of PKC activity with phorbol 12-myristate 13-acetate (PMA) enhanced the development of myogenic tone.	Tetradecanoylphorbol Acetate	171-174	proline rich transmembrane protein 2	Homo sapiens	120-123
17433258-8	2007	All peptides tested were effective at preventing IL-8 release from phorbol 12-myristate 13-acetate (PMA)/copper-stimulated human umbilical vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
17674818-7	2007	TPA enhanced lipid peroxidation with reduction in the level of catalase, glutathione, glutathione peroxidase, glutathione reductase and glutathione-s-transferase.	Tetradecanoylphorbol Acetate	0-3	catalase	Mus musculus	63-71
17552910-3	2007	Gliovirin inhibited inducible TNF-alpha promoter activity and synthesis in LPS/IFN-gamma-stimulated macrophages/monocytes and Jurkat T-cells, co-stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA)/ionomycin, in a dose-dependent manner, with IC(50) values ranging from 0.21 to 2.1 microM (0.1-1 microg/ml).	Tetradecanoylphorbol Acetate	161-197	interferon gamma	Homo sapiens	79-88
17552910-3	2007	Gliovirin inhibited inducible TNF-alpha promoter activity and synthesis in LPS/IFN-gamma-stimulated macrophages/monocytes and Jurkat T-cells, co-stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA)/ionomycin, in a dose-dependent manner, with IC(50) values ranging from 0.21 to 2.1 microM (0.1-1 microg/ml).	Tetradecanoylphorbol Acetate	199-202	interferon gamma	Homo sapiens	79-88
17552910-5	2007	Gliovirin also significantly reduced TPA/ionomycin-induced IL-2 mRNA levels and synthesis in Jurkat cells at low micromolar concentrations.	Tetradecanoylphorbol Acetate	37-40	interleukin 2	Homo sapiens	59-63
17355247-10	2007	Moreover, leptin enhanced the expression of CD69 and CD25 on CD4(+) and CD8(+) cells after stimulation with PMA-ionomycin.	Tetradecanoylphorbol Acetate	108-111	CD4 molecule	Homo sapiens	61-64
17516243-3	2007	Phorbol-12-myristate 13-acetate (PMA; 100 ng/ml) caused an increase in fluorescence and lucigenin chemiluminescence in HL-60, which was abolished by superoxide dismutase (SOD; 600 U/ml) indicating that DHE detects extracellular superoxide.	Tetradecanoylphorbol Acetate	0-31	superoxide dismutase 1	Homo sapiens	149-169
17516243-3	2007	Phorbol-12-myristate 13-acetate (PMA; 100 ng/ml) caused an increase in fluorescence and lucigenin chemiluminescence in HL-60, which was abolished by superoxide dismutase (SOD; 600 U/ml) indicating that DHE detects extracellular superoxide.	Tetradecanoylphorbol Acetate	0-31	superoxide dismutase 1	Homo sapiens	171-174
17516243-3	2007	Phorbol-12-myristate 13-acetate (PMA; 100 ng/ml) caused an increase in fluorescence and lucigenin chemiluminescence in HL-60, which was abolished by superoxide dismutase (SOD; 600 U/ml) indicating that DHE detects extracellular superoxide.	Tetradecanoylphorbol Acetate	33-36	superoxide dismutase 1	Homo sapiens	149-169
17516243-3	2007	Phorbol-12-myristate 13-acetate (PMA; 100 ng/ml) caused an increase in fluorescence and lucigenin chemiluminescence in HL-60, which was abolished by superoxide dismutase (SOD; 600 U/ml) indicating that DHE detects extracellular superoxide.	Tetradecanoylphorbol Acetate	33-36	superoxide dismutase 1	Homo sapiens	171-174
17234720-5	2007	To further elucidate the molecular mechanisms underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling molecules controlling these proteins were explored in mouse skin.	Tetradecanoylphorbol Acetate	126-129	nitric oxide synthase 2, inducible	Mus musculus	212-243
17234720-5	2007	To further elucidate the molecular mechanisms underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling molecules controlling these proteins were explored in mouse skin.	Tetradecanoylphorbol Acetate	126-129	nitric oxide synthase 2, inducible	Mus musculus	245-249
17234720-7	2007	When mouse skin was treated after TPA-induced production of papillomas, xanthorrhizol remarkably suppressed the expression of ODC, iNOS and COX-2 and inhibited the activation of NF-kappaB.	Tetradecanoylphorbol Acetate	34-37	nitric oxide synthase 2, inducible	Mus musculus	131-135
17408801-8	2007	IRS-4 down-regulation abolished IGF-I-, TPA- and IGF-I plus TPA-stimulated ERK and p70S6K activities.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 1	Homo sapiens	75-78
17408801-8	2007	IRS-4 down-regulation abolished IGF-I-, TPA- and IGF-I plus TPA-stimulated ERK and p70S6K activities.	Tetradecanoylphorbol Acetate	60-63	mitogen-activated protein kinase 1	Homo sapiens	75-78
17445854-4	2007	Exposure to model substances like ethanol or phorbol 12-myristate 13-acetate (PMA) revealed a correlation between ERK1/2 activation and cell migration.	Tetradecanoylphorbol Acetate	45-76	mitogen-activated protein kinase 3	Homo sapiens	114-120
17939399-1	2007	OBJECTIVE: To explore the changes in expression of WT1 gene and ration of its isomers during phorbol ester (TPA) induced differentiation of leukemia cell line K562 by fluorescence quantitative RT-PCR and analysis the relationship between different isomers and hematogenic cell differentiation.	Tetradecanoylphorbol Acetate	108-111	WT1 transcription factor	Homo sapiens	51-54
17939399-11	2007	CONCLUSION: During the TPA induced differentiation of K562 cell, there are two high expression levels of WT1 gene.	Tetradecanoylphorbol Acetate	23-26	WT1 transcription factor	Homo sapiens	105-108
17389749-7	2007	Treatment of the hepatocellular carcinoma cell line HepG2 with PKC activator phorbol 12-myristate 13-acetate also resulted in increased cytoplasmic localization of HNF4alpha as well as decreased endogenous HNF4alpha protein levels in a proteasome-dependent fashion.	Tetradecanoylphorbol Acetate	77-108	hepatocyte nuclear factor 4 alpha	Homo sapiens	164-173
17389749-7	2007	Treatment of the hepatocellular carcinoma cell line HepG2 with PKC activator phorbol 12-myristate 13-acetate also resulted in increased cytoplasmic localization of HNF4alpha as well as decreased endogenous HNF4alpha protein levels in a proteasome-dependent fashion.	Tetradecanoylphorbol Acetate	77-108	hepatocyte nuclear factor 4 alpha	Homo sapiens	206-215
17447747-7	2007	uPA inhibitor 26 was selected for further evaluation based on its excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).	Tetradecanoylphorbol Acetate	144-147	plasminogen activator, urokinase	Homo sapiens	0-3
17171646-9	2007	Phorbol myristate acetate (PMA, 100 nM) that completely depleted PKC-alpha also enhanced cancer cell proliferation and attenuated VIN-induced cytotoxicity.	Tetradecanoylphorbol Acetate	0-25	protein kinase C alpha	Homo sapiens	65-74
17171646-9	2007	Phorbol myristate acetate (PMA, 100 nM) that completely depleted PKC-alpha also enhanced cancer cell proliferation and attenuated VIN-induced cytotoxicity.	Tetradecanoylphorbol Acetate	27-30	protein kinase C alpha	Homo sapiens	65-74
17445854-4	2007	Exposure to model substances like ethanol or phorbol 12-myristate 13-acetate (PMA) revealed a correlation between ERK1/2 activation and cell migration.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 3	Homo sapiens	114-120
17146445-11	2007	Pretreatment of U-1242-PKC-eta cells with inhibitors of PKC or MAPK/ERK kinase (MEK) (bisindolyl maleimide (BIM) or U0126, respectively) blocked both PMA-induced Elk-1 transcriptional activity and PMA-stimulated proliferation.	Tetradecanoylphorbol Acetate	150-153	protein kinase C eta	Homo sapiens	23-26
17146445-11	2007	Pretreatment of U-1242-PKC-eta cells with inhibitors of PKC or MAPK/ERK kinase (MEK) (bisindolyl maleimide (BIM) or U0126, respectively) blocked both PMA-induced Elk-1 transcriptional activity and PMA-stimulated proliferation.	Tetradecanoylphorbol Acetate	150-153	mitogen-activated protein kinase 1	Homo sapiens	68-71
17267550-12	2007	Treatment of cells with 100 nM PMA for 24 h, to downregulate PKC, reduced [Ca(2+)](i) transients by 49.9 +/- 5.2% (at 1 mM Ca(2+)) and 40.5 +/- 6.5% (at 2 mM Ca(2+)), compared with controls.	Tetradecanoylphorbol Acetate	31-34	protein kinase C alpha	Homo sapiens	61-64
17220369-4	2007	In this study we show a signaling pathway on the plasma surface of human airway epithelial NCI-H292 cells that regulate IL-8 production in response to a model inflammatory stimulus, phorbol 12-myristate 13-acetate, and a pathophysiological stimulus, gram-negative bacterial lipopolysaccharide.	Tetradecanoylphorbol Acetate	182-213	C-X-C motif chemokine ligand 8	Homo sapiens	120-124
17210245-5	2007	The down-regulation of ZO-1 caused a stable interaction of PKC-gamma with Cx43 even without normal enzyme activation by TPA.	Tetradecanoylphorbol Acetate	120-123	tight junction protein 1	Homo sapiens	23-27
17114644-0	2007	Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase kinase 7	Homo sapiens	100-103
17114644-0	2007	Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 1	Homo sapiens	104-107
17114644-0	2007	Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms.	Tetradecanoylphorbol Acetate	24-27	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-116
17114644-6	2007	In addition, ascofuranone suppressed PMA-induced phosphorylation of Ras, Raf, MEK and extracellular signal-regulated kinase (ERK), upstream factors involved in AP-1activation, whereas the phosphorylation of p38 and JNK/mitogen-activated protein kinase was not affected by ascofuranone, suggesting that the primary target of ascofuranone for suppression of the AP-1 induction is present in upstream of ERK signaling pathway.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase kinase 7	Homo sapiens	78-81
17114644-6	2007	In addition, ascofuranone suppressed PMA-induced phosphorylation of Ras, Raf, MEK and extracellular signal-regulated kinase (ERK), upstream factors involved in AP-1activation, whereas the phosphorylation of p38 and JNK/mitogen-activated protein kinase was not affected by ascofuranone, suggesting that the primary target of ascofuranone for suppression of the AP-1 induction is present in upstream of ERK signaling pathway.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 1	Homo sapiens	86-123
17114644-6	2007	In addition, ascofuranone suppressed PMA-induced phosphorylation of Ras, Raf, MEK and extracellular signal-regulated kinase (ERK), upstream factors involved in AP-1activation, whereas the phosphorylation of p38 and JNK/mitogen-activated protein kinase was not affected by ascofuranone, suggesting that the primary target of ascofuranone for suppression of the AP-1 induction is present in upstream of ERK signaling pathway.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 1	Homo sapiens	125-128
17114644-6	2007	In addition, ascofuranone suppressed PMA-induced phosphorylation of Ras, Raf, MEK and extracellular signal-regulated kinase (ERK), upstream factors involved in AP-1activation, whereas the phosphorylation of p38 and JNK/mitogen-activated protein kinase was not affected by ascofuranone, suggesting that the primary target of ascofuranone for suppression of the AP-1 induction is present in upstream of ERK signaling pathway.	Tetradecanoylphorbol Acetate	37-40	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	160-164
17114644-6	2007	In addition, ascofuranone suppressed PMA-induced phosphorylation of Ras, Raf, MEK and extracellular signal-regulated kinase (ERK), upstream factors involved in AP-1activation, whereas the phosphorylation of p38 and JNK/mitogen-activated protein kinase was not affected by ascofuranone, suggesting that the primary target of ascofuranone for suppression of the AP-1 induction is present in upstream of ERK signaling pathway.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 14	Homo sapiens	207-210
17114644-6	2007	In addition, ascofuranone suppressed PMA-induced phosphorylation of Ras, Raf, MEK and extracellular signal-regulated kinase (ERK), upstream factors involved in AP-1activation, whereas the phosphorylation of p38 and JNK/mitogen-activated protein kinase was not affected by ascofuranone, suggesting that the primary target of ascofuranone for suppression of the AP-1 induction is present in upstream of ERK signaling pathway.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 8	Homo sapiens	215-218
17386409-5	2007	Panepoxydone strongly inhibited hTNF-alpha, IL-8 and NF-kappaB promoter activity in LPS/TPA stimulated MonoMac6 cells with IC(50) values of 0.5-1 microg/ml by blocking the phosphorylation of IkappaB and subsequent binding of the activated NF-kappaB transcription factor to the DNA.	Tetradecanoylphorbol Acetate	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
17114644-6	2007	In addition, ascofuranone suppressed PMA-induced phosphorylation of Ras, Raf, MEK and extracellular signal-regulated kinase (ERK), upstream factors involved in AP-1activation, whereas the phosphorylation of p38 and JNK/mitogen-activated protein kinase was not affected by ascofuranone, suggesting that the primary target of ascofuranone for suppression of the AP-1 induction is present in upstream of ERK signaling pathway.	Tetradecanoylphorbol Acetate	37-40	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	360-364
17114644-6	2007	In addition, ascofuranone suppressed PMA-induced phosphorylation of Ras, Raf, MEK and extracellular signal-regulated kinase (ERK), upstream factors involved in AP-1activation, whereas the phosphorylation of p38 and JNK/mitogen-activated protein kinase was not affected by ascofuranone, suggesting that the primary target of ascofuranone for suppression of the AP-1 induction is present in upstream of ERK signaling pathway.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 1	Homo sapiens	401-404
17485345-7	2007	While the level of Thr456 phosphorylation is very low in confluent cells, exposure of stationary BHK 165-23 cells to the PKC activator, phorbol 12-myristate-13-acetate (PMA) resulted in a 3-fold increase in the modification of this residue.	Tetradecanoylphorbol Acetate	136-167	proline rich transmembrane protein 2	Homo sapiens	121-124
17485345-7	2007	While the level of Thr456 phosphorylation is very low in confluent cells, exposure of stationary BHK 165-23 cells to the PKC activator, phorbol 12-myristate-13-acetate (PMA) resulted in a 3-fold increase in the modification of this residue.	Tetradecanoylphorbol Acetate	169-172	proline rich transmembrane protein 2	Homo sapiens	121-124
17386407-2	2007	Topical application of TPA to the ears induced acute inflammation, accompanied by mast cell degranulation in +/+ mice, which peaked at 6-12 h. There was no significant difference in ear thickness between the groups until 12 h, but the swelling was greater in W/W(v) mice than +/+ mice at 24-36 h. Western blot analysis revealed that TPA-induced marked increases in levels of proMMP-9 and tissue inhibitor of metalloproteinases-1 (TIMP-1), which existed as complexes with proMMP-9.	Tetradecanoylphorbol Acetate	23-26	tissue inhibitor of metalloproteinase 1	Mus musculus	388-428
17386409-5	2007	Panepoxydone strongly inhibited hTNF-alpha, IL-8 and NF-kappaB promoter activity in LPS/TPA stimulated MonoMac6 cells with IC(50) values of 0.5-1 microg/ml by blocking the phosphorylation of IkappaB and subsequent binding of the activated NF-kappaB transcription factor to the DNA.	Tetradecanoylphorbol Acetate	88-91	nuclear factor kappa B subunit 1	Homo sapiens	53-62
17386407-2	2007	Topical application of TPA to the ears induced acute inflammation, accompanied by mast cell degranulation in +/+ mice, which peaked at 6-12 h. There was no significant difference in ear thickness between the groups until 12 h, but the swelling was greater in W/W(v) mice than +/+ mice at 24-36 h. Western blot analysis revealed that TPA-induced marked increases in levels of proMMP-9 and tissue inhibitor of metalloproteinases-1 (TIMP-1), which existed as complexes with proMMP-9.	Tetradecanoylphorbol Acetate	23-26	tissue inhibitor of metalloproteinase 1	Mus musculus	430-436
17386409-5	2007	Panepoxydone strongly inhibited hTNF-alpha, IL-8 and NF-kappaB promoter activity in LPS/TPA stimulated MonoMac6 cells with IC(50) values of 0.5-1 microg/ml by blocking the phosphorylation of IkappaB and subsequent binding of the activated NF-kappaB transcription factor to the DNA.	Tetradecanoylphorbol Acetate	88-91	nuclear factor kappa B subunit 1	Homo sapiens	239-248
17394101-4	2007	Deerberry fruit extracts also blocked TPA- or UVB-induced phosphorylation of ERKs and MEK 1/2, two upstream regulators of AP-1 and inhibited proliferation of human leukemia HL-60 cancer cells and human lung epithelial cancer A549 cells and induced apoptosis of HL-60 cells.	Tetradecanoylphorbol Acetate	38-41	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	122-126
17207890-5	2007	TNF-alpha stimulated expression of both chemokines, while the PKCalpha/beta activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced only expression of IL-8 and inhibited TNF-alpha-induced RANTES expression.	Tetradecanoylphorbol Acetate	86-123	protein kinase C alpha	Homo sapiens	62-75
17207890-5	2007	TNF-alpha stimulated expression of both chemokines, while the PKCalpha/beta activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced only expression of IL-8 and inhibited TNF-alpha-induced RANTES expression.	Tetradecanoylphorbol Acetate	86-123	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
17207890-5	2007	TNF-alpha stimulated expression of both chemokines, while the PKCalpha/beta activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced only expression of IL-8 and inhibited TNF-alpha-induced RANTES expression.	Tetradecanoylphorbol Acetate	86-123	tumor necrosis factor	Homo sapiens	176-185
17207890-5	2007	TNF-alpha stimulated expression of both chemokines, while the PKCalpha/beta activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced only expression of IL-8 and inhibited TNF-alpha-induced RANTES expression.	Tetradecanoylphorbol Acetate	125-128	protein kinase C alpha	Homo sapiens	62-75
17207890-5	2007	TNF-alpha stimulated expression of both chemokines, while the PKCalpha/beta activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced only expression of IL-8 and inhibited TNF-alpha-induced RANTES expression.	Tetradecanoylphorbol Acetate	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	157-161
17207890-5	2007	TNF-alpha stimulated expression of both chemokines, while the PKCalpha/beta activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced only expression of IL-8 and inhibited TNF-alpha-induced RANTES expression.	Tetradecanoylphorbol Acetate	125-128	tumor necrosis factor	Homo sapiens	176-185
17207890-6	2007	The PKCalpha/beta inhibitor Go 6976 increased TNF-alpha-induced RANTES production and prevented its down-regulation by TPA.	Tetradecanoylphorbol Acetate	119-122	protein kinase C alpha	Homo sapiens	4-12
17207890-7	2007	In contrast, it decreased TNF-alpha or TPA-induced IL-8 release.	Tetradecanoylphorbol Acetate	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	51-55
17207890-10	2007	An AP-1 and a NF-kappaB recognition sites were necessary for full induction of IL-8 promoter activity by TNF-alpha and TPA.	Tetradecanoylphorbol Acetate	119-122	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	3-7
17207890-10	2007	An AP-1 and a NF-kappaB recognition sites were necessary for full induction of IL-8 promoter activity by TNF-alpha and TPA.	Tetradecanoylphorbol Acetate	119-122	nuclear factor kappa B subunit 1	Homo sapiens	14-23
17207890-10	2007	An AP-1 and a NF-kappaB recognition sites were necessary for full induction of IL-8 promoter activity by TNF-alpha and TPA.	Tetradecanoylphorbol Acetate	119-122	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
17207890-12	2007	Immunoblotting experiments showed that TPA was more potent than TNF-alpha to induce in a PKCalpha/beta dependent manner the p44/p42 mitogen-activated protein kinases (MAPK) signaling cascade which controls AP-1 activity.	Tetradecanoylphorbol Acetate	39-42	protein kinase C alpha	Homo sapiens	89-102
17207890-12	2007	Immunoblotting experiments showed that TPA was more potent than TNF-alpha to induce in a PKCalpha/beta dependent manner the p44/p42 mitogen-activated protein kinases (MAPK) signaling cascade which controls AP-1 activity.	Tetradecanoylphorbol Acetate	39-42	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	206-210
17207890-13	2007	Conversely, TPA inhibited TNF-alpha-induced NF-kappaB signaling and was a weak activator of this pathway.	Tetradecanoylphorbol Acetate	12-15	tumor necrosis factor	Homo sapiens	26-35
17207890-13	2007	Conversely, TPA inhibited TNF-alpha-induced NF-kappaB signaling and was a weak activator of this pathway.	Tetradecanoylphorbol Acetate	12-15	nuclear factor kappa B subunit 1	Homo sapiens	44-53
17207890-14	2007	Thus, TPA did not sufficiently activate NF-kappaB to increase transcription through the low affinity NF-kappaB binding sites on RANTES promoter and its inhibitory effect on TNF-alpha-induced NF-kappaB signaling resulted in a reduced transcription rate.	Tetradecanoylphorbol Acetate	6-9	tumor necrosis factor	Homo sapiens	173-182
17321112-9	2007	Protein kinase C (PKC) activation by phorbol myristate acetate (PMA) potentiated IL-6 mRNA expression, whereas PKC inhibition by bisindolylmaleimide blocked SPC-induced p42/44 ERK phosphorylation and IL-6 expression.	Tetradecanoylphorbol Acetate	37-62	protein kinase C alpha	Homo sapiens	18-21
17321112-9	2007	Protein kinase C (PKC) activation by phorbol myristate acetate (PMA) potentiated IL-6 mRNA expression, whereas PKC inhibition by bisindolylmaleimide blocked SPC-induced p42/44 ERK phosphorylation and IL-6 expression.	Tetradecanoylphorbol Acetate	37-62	interleukin 6	Homo sapiens	81-85
17321112-9	2007	Protein kinase C (PKC) activation by phorbol myristate acetate (PMA) potentiated IL-6 mRNA expression, whereas PKC inhibition by bisindolylmaleimide blocked SPC-induced p42/44 ERK phosphorylation and IL-6 expression.	Tetradecanoylphorbol Acetate	64-67	protein kinase C alpha	Homo sapiens	18-21
17321112-9	2007	Protein kinase C (PKC) activation by phorbol myristate acetate (PMA) potentiated IL-6 mRNA expression, whereas PKC inhibition by bisindolylmaleimide blocked SPC-induced p42/44 ERK phosphorylation and IL-6 expression.	Tetradecanoylphorbol Acetate	64-67	interleukin 6	Homo sapiens	81-85
17394101-5	2007	These results suggest that the inhibition of TPA- or UVB-induced AP-1 and NF-kappaB activity, inhibition of HL-60 cells and cancer A549 cells proliferation and induction of apoptotic in human leukemia HL-60 cancer cells may be mediated through the ERKs and MEK 1/2 signal pathway.	Tetradecanoylphorbol Acetate	45-48	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-69
17400819-3	2007	A serum shock and the phorbol ester TPA induced Noc transcript levels in quiescent NIH3T3 cultures while dexamethasone and forskolin, which are known to induce other clock genes in culture, were without effect.	Tetradecanoylphorbol Acetate	36-39	nocturnin	Mus musculus	48-51
17481552-4	2007	In this review, we provide evidence for reduced COX-2 transcriptional expression in response to phorbol esters (PMA), lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha).	Tetradecanoylphorbol Acetate	112-115	prostaglandin-endoperoxide synthase 2	Homo sapiens	48-53
17481552-4	2007	In this review, we provide evidence for reduced COX-2 transcriptional expression in response to phorbol esters (PMA), lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha).	Tetradecanoylphorbol Acetate	112-115	tumor necrosis factor	Homo sapiens	177-204
17481552-4	2007	In this review, we provide evidence for reduced COX-2 transcriptional expression in response to phorbol esters (PMA), lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha).	Tetradecanoylphorbol Acetate	112-115	tumor necrosis factor	Homo sapiens	206-214
17400819-5	2007	The half-life of the TPA-induced Noc mRNA is short, and the inhibition of protein synthesis by cycloheximide prevents Noc mRNA degradation and revealed a 30-fold increase in the transcript levels after 4 h of TPA treatment.	Tetradecanoylphorbol Acetate	21-24	nocturnin	Mus musculus	33-36
17400819-5	2007	The half-life of the TPA-induced Noc mRNA is short, and the inhibition of protein synthesis by cycloheximide prevents Noc mRNA degradation and revealed a 30-fold increase in the transcript levels after 4 h of TPA treatment.	Tetradecanoylphorbol Acetate	21-24	nocturnin	Mus musculus	118-121
17400819-5	2007	The half-life of the TPA-induced Noc mRNA is short, and the inhibition of protein synthesis by cycloheximide prevents Noc mRNA degradation and revealed a 30-fold increase in the transcript levels after 4 h of TPA treatment.	Tetradecanoylphorbol Acetate	209-212	nocturnin	Mus musculus	33-36
17438459-9	2007	High-dose (0.5 mg/mL) r-tPA lavage increased fibrinolysis, demonstrated by low abdominal plasminogen activator inhibitor 1 levels and elevated pulmonary tPA levels, resulting in reduced abdominal bacterial load, chemokine levels, leukocyte influx, and thrombin generation, along with less pulmonary fibrin depositions and organ damage on histological examination (P &lt; 0.05 vs. saline lavage).	Tetradecanoylphorbol Acetate	24-27	coagulation factor II	Mus musculus	252-260
17464189-1	2007	Previously we showed that the human GM3 synthase gene was expressed during the induction of megakaryocytic differentiation in human leukemia K562 cells by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	155-186	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	36-48
17464189-1	2007	Previously we showed that the human GM3 synthase gene was expressed during the induction of megakaryocytic differentiation in human leukemia K562 cells by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	188-191	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	36-48
17464189-2	2007	In this study we found that treatment of PMA-induced K562 cells with Go6976, a specific inhibitor of PKC, and U0126, an inhibitor of the extracellular signal-regulated kinase (ERK) reduced expression of GM3 synthase, whereas wortmannin, an inhibitor of phosphoinositide 3-kinase (PI3K) did not.	Tetradecanoylphorbol Acetate	41-44	mitogen-activated protein kinase 1	Homo sapiens	137-174
17464189-2	2007	In this study we found that treatment of PMA-induced K562 cells with Go6976, a specific inhibitor of PKC, and U0126, an inhibitor of the extracellular signal-regulated kinase (ERK) reduced expression of GM3 synthase, whereas wortmannin, an inhibitor of phosphoinositide 3-kinase (PI3K) did not.	Tetradecanoylphorbol Acetate	41-44	mitogen-activated protein kinase 1	Homo sapiens	176-179
17464189-2	2007	In this study we found that treatment of PMA-induced K562 cells with Go6976, a specific inhibitor of PKC, and U0126, an inhibitor of the extracellular signal-regulated kinase (ERK) reduced expression of GM3 synthase, whereas wortmannin, an inhibitor of phosphoinositide 3-kinase (PI3K) did not.	Tetradecanoylphorbol Acetate	41-44	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	203-215
17303575-7	2007	Here we show that PMA selectively activates ASMase and that ASMase accounts for the majority of PMA-induced ceramide.	Tetradecanoylphorbol Acetate	18-21	sphingomyelin phosphodiesterase 1	Homo sapiens	44-50
17440073-0	2007	SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation.	Tetradecanoylphorbol Acetate	97-133	Ras-like without CAAX 2	Mus musculus	4-8
17303575-14	2007	Moreover, when transiently overexpressed, ASMase(S508A) blocked the ceramide formation after PMA treatment, suggesting a dominant negative function for this mutant.	Tetradecanoylphorbol Acetate	93-96	sphingomyelin phosphodiesterase 1	Homo sapiens	42-48
17430640-5	2007	Furthermore, ergolide-mediated protein kinase Calpha (PKCalpha) inhibition is involved in reduction of NF-kappaB inhibition, as demonstrated by the observation that dominant negative PKCalpha, but not p44/42 MAPK and p38 MAPK, inhibits TPA-stimulated reporter gene expression.	Tetradecanoylphorbol Acetate	236-239	protein kinase C alpha	Homo sapiens	54-62
17350626-7	2007	Both the IL-6 synthesis and the phosphorylation of p44/p42 MAP kinase stimulated by 12-O-tetradecanoylphorbol 13-acetate (TPA), a direct activator of PKC, were markedly suppressed by EGCG.	Tetradecanoylphorbol Acetate	84-120	interleukin 6	Mus musculus	9-13
17350626-7	2007	Both the IL-6 synthesis and the phosphorylation of p44/p42 MAP kinase stimulated by 12-O-tetradecanoylphorbol 13-acetate (TPA), a direct activator of PKC, were markedly suppressed by EGCG.	Tetradecanoylphorbol Acetate	122-125	interleukin 6	Mus musculus	9-13
17194723-5	2007	In reporter assays, 17beta-estradiol (E2) at a physiologically high concentration increased the activity of NF-kappaB in Jurkat cells stimulated by PMA/ionomycin or TNF-alpha.	Tetradecanoylphorbol Acetate	148-151	nuclear factor kappa B subunit 1	Homo sapiens	108-117
17284253-3	2007	We applied an in vitro differentiation model of HL-60 cells with 12-0-tetradecanoylphorbol-13-acetate (TPA), in which nuclear translocation of heparanase was observed using immunohistochemical analysis.	Tetradecanoylphorbol Acetate	103-106	heparanase	Homo sapiens	143-153
17485888-7	2007	Treatment of the cells with phorbol 12-myristate 13-acetate, which induces the differentiation of the cells into macrophage-like cells, significantly enhanced the IFN-gamma -induced RIG-I expression.	Tetradecanoylphorbol Acetate	28-59	interferon gamma	Homo sapiens	163-172
17394769-3	2007	Though no apparent elevation of ERK activity was observed during the apoptosis in NB4 cells caused by 20 microM sodium selenite treatment, PD98059 and U0126, specific chemical inhibitors of the MEK/ERK signaling pathway, were shown to strongly prevent the apoptosis process, while ERK activator TPA enhanced the process.	Tetradecanoylphorbol Acetate	295-298	mitogen-activated protein kinase kinase 7	Homo sapiens	194-197
17425422-8	2007	With PMA/ionomycin stimulation, the percent IL-17 expression in CD4(+) cells (median) was 1.45 versus 0.65 (p&lt; 0.0001) and in CD4() T cells it was 1.0 versus 0.12 (p&lt; 0.0001).	Tetradecanoylphorbol Acetate	5-8	CD4 molecule	Homo sapiens	64-67
17425422-8	2007	With PMA/ionomycin stimulation, the percent IL-17 expression in CD4(+) cells (median) was 1.45 versus 0.65 (p&lt; 0.0001) and in CD4() T cells it was 1.0 versus 0.12 (p&lt; 0.0001).	Tetradecanoylphorbol Acetate	5-8	CD4 molecule	Homo sapiens	129-132
17425422-10	2007	IL-17 expression was further inducible by PMA/ionomycin stimulation in vitro only in CD4(+) T cells.	Tetradecanoylphorbol Acetate	42-45	CD4 molecule	Homo sapiens	85-88
17258194-6	2007	Moreover, alpha-amyrin given topically dose-dependently inhibited the activation of upstream protein kinases, namely extracellular signal-regulated protein kinase (ERK), p38 mitogen-activated protein kinase (MAPK) and protein kinase C (PKC)alpha, following topical TPA treatment.	Tetradecanoylphorbol Acetate	265-268	protein kinase C, alpha	Mus musculus	236-245
17210122-0	2007	Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation.	Tetradecanoylphorbol Acetate	31-34	suppressor of cytokine signaling 6	Homo sapiens	10-15
17360902-4	2007	Here, we show that 4beta-phorbol-12-myristate-13-acetate (4betaPMA), a stereoselective C-1 diacylglycerol-binding site agonist, enhances voltage-dependent opening of wild-type and cAMP/H+(I)-uncoupled hyperpolarization-activated, cyclic nucleotide-regulated (HCN) channels, but does not alter gating of the plant hyperpolarization-activated channel, KAT1.	Tetradecanoylphorbol Acetate	19-56	kynurenine aminotransferase 1	Homo sapiens	350-354
17360902-4	2007	Here, we show that 4beta-phorbol-12-myristate-13-acetate (4betaPMA), a stereoselective C-1 diacylglycerol-binding site agonist, enhances voltage-dependent opening of wild-type and cAMP/H+(I)-uncoupled hyperpolarization-activated, cyclic nucleotide-regulated (HCN) channels, but does not alter gating of the plant hyperpolarization-activated channel, KAT1.	Tetradecanoylphorbol Acetate	58-66	kynurenine aminotransferase 1	Homo sapiens	350-354
17210122-0	2007	Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 1	Homo sapiens	74-77
17094021-5	2007	DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	106-137	tumor necrosis factor	Homo sapiens	73-82
17288985-4	2007	The PKC activator, phorbol 12-myristate 13-acetate (PMA), increased luciferase expression of constructs containing the apoB 5" UTR whereas treatment with Bis-I, a general PKC inhibitor or Go6976, a more specific PKC alpha/beta inhibitor, decreased expression, under both basal and insulin-treated conditions.	Tetradecanoylphorbol Acetate	19-50	apolipoprotein B	Homo sapiens	119-123
17288985-4	2007	The PKC activator, phorbol 12-myristate 13-acetate (PMA), increased luciferase expression of constructs containing the apoB 5" UTR whereas treatment with Bis-I, a general PKC inhibitor or Go6976, a more specific PKC alpha/beta inhibitor, decreased expression, under both basal and insulin-treated conditions.	Tetradecanoylphorbol Acetate	19-50	insulin	Homo sapiens	281-288
17288985-4	2007	The PKC activator, phorbol 12-myristate 13-acetate (PMA), increased luciferase expression of constructs containing the apoB 5" UTR whereas treatment with Bis-I, a general PKC inhibitor or Go6976, a more specific PKC alpha/beta inhibitor, decreased expression, under both basal and insulin-treated conditions.	Tetradecanoylphorbol Acetate	52-55	apolipoprotein B	Homo sapiens	119-123
17094021-5	2007	DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	139-142	interleukin 6	Homo sapiens	98-102
17288985-4	2007	The PKC activator, phorbol 12-myristate 13-acetate (PMA), increased luciferase expression of constructs containing the apoB 5" UTR whereas treatment with Bis-I, a general PKC inhibitor or Go6976, a more specific PKC alpha/beta inhibitor, decreased expression, under both basal and insulin-treated conditions.	Tetradecanoylphorbol Acetate	52-55	insulin	Homo sapiens	281-288
17094021-5	2007	DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	106-137	interleukin 1 beta	Homo sapiens	84-92
17094021-5	2007	DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	106-137	interleukin 6	Homo sapiens	98-102
17094021-5	2007	DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	139-142	tumor necrosis factor	Homo sapiens	73-82
17094021-5	2007	DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	139-142	interleukin 1 beta	Homo sapiens	84-92
17279541-4	2007	N-methyl-D-aspartate (NMDA)- and KCl-induced phosphorylation of ERK was significantly attenuated in Hpca(-/-) hippocampal slices, as was ionomycin-induced phosphorylation of ERK, whereas forskolin and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulation yielded indistinguishable levels of ERK phosphorylation in both wild-type and Hpca(-/-) slices.	Tetradecanoylphorbol Acetate	201-238	mitogen-activated protein kinase 1	Mus musculus	64-67
17332304-9	2007	Basal and epidermal growth factor-induced ERK1/2 phosphorylation was inhibited in several cell lines as well as 12-O-tetradecanoylphorbol-13-acetate-induced ERK1/2 phosphorylation in isolated peripheral blood mononuclear cells.	Tetradecanoylphorbol Acetate	112-148	mitogen-activated protein kinase 3	Homo sapiens	157-163
17149700-8	2007	Notably, 12-O-tetradecanoyl-13-phorbol acetate (TPA) mediated intracellular translocation of RACK1-interacting PKC alpha and delta was abrogated in RACK1DeltaWD1-expressing cells.	Tetradecanoylphorbol Acetate	48-51	protein kinase C, alpha	Mus musculus	111-120
17131377-5	2007	ICAM-1 expression in response to TPA was inhibited by pretreatment with GF109203X [a specific inhibitor of protein kinase C (PKC)], or with PD98059 and U0126 (specific inhibitors of MEK), suggesting the importance of PKC, and Erk1/2 signaling cascades in this response.	Tetradecanoylphorbol Acetate	33-36	mitogen-activated protein kinase kinase 7	Homo sapiens	182-185
17131377-5	2007	ICAM-1 expression in response to TPA was inhibited by pretreatment with GF109203X [a specific inhibitor of protein kinase C (PKC)], or with PD98059 and U0126 (specific inhibitors of MEK), suggesting the importance of PKC, and Erk1/2 signaling cascades in this response.	Tetradecanoylphorbol Acetate	33-36	mitogen-activated protein kinase 3	Homo sapiens	226-232
17131377-6	2007	Interestingly, ICAM-1 expression in response to TPA-induced PKC activation was linked to the generation of reactive oxygen species (ROS), as pretreatment with NAC (an ROS scavenger) blocked both ErK1/2 activation and ICAM-1 expression induced by TPA.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 3	Homo sapiens	195-201
17131377-9	2007	Together, these observations demonstrated that TPA, a potent activator of PKC, induces ICAM-1 expression via a ROS- and ERK1/2-dependent signaling mechanism in ML-1 cells.	Tetradecanoylphorbol Acetate	47-50	mitogen-activated protein kinase 3	Homo sapiens	120-126
17279541-4	2007	N-methyl-D-aspartate (NMDA)- and KCl-induced phosphorylation of ERK was significantly attenuated in Hpca(-/-) hippocampal slices, as was ionomycin-induced phosphorylation of ERK, whereas forskolin and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulation yielded indistinguishable levels of ERK phosphorylation in both wild-type and Hpca(-/-) slices.	Tetradecanoylphorbol Acetate	201-238	hippocalcin	Mus musculus	100-104
17279541-4	2007	N-methyl-D-aspartate (NMDA)- and KCl-induced phosphorylation of ERK was significantly attenuated in Hpca(-/-) hippocampal slices, as was ionomycin-induced phosphorylation of ERK, whereas forskolin and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulation yielded indistinguishable levels of ERK phosphorylation in both wild-type and Hpca(-/-) slices.	Tetradecanoylphorbol Acetate	240-243	mitogen-activated protein kinase 1	Mus musculus	64-67
17279541-4	2007	N-methyl-D-aspartate (NMDA)- and KCl-induced phosphorylation of ERK was significantly attenuated in Hpca(-/-) hippocampal slices, as was ionomycin-induced phosphorylation of ERK, whereas forskolin and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulation yielded indistinguishable levels of ERK phosphorylation in both wild-type and Hpca(-/-) slices.	Tetradecanoylphorbol Acetate	240-243	hippocalcin	Mus musculus	100-104
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	62-93	cyclin dependent kinase inhibitor 1A	Homo sapiens	202-205
17027084-2	2007	Here, we found that phorbol 12-myristate 13-acetate (PMA) alone did not induce IL-3 gene expression, but potentiated A23187-induced IL-3 gene expression.	Tetradecanoylphorbol Acetate	20-51	interleukin 3	Mus musculus	132-136
17027084-2	2007	Here, we found that phorbol 12-myristate 13-acetate (PMA) alone did not induce IL-3 gene expression, but potentiated A23187-induced IL-3 gene expression.	Tetradecanoylphorbol Acetate	53-56	interleukin 3	Mus musculus	132-136
17178924-6	2007	IL-1beta-, FBS-, or PMA-induced stabilization of B1 receptor mRNA was inhibited by the addition of the protein kinase C inhibitor 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride (GF-109203x), which also diminished the Bmax under FBS or PMA treatment.	Tetradecanoylphorbol Acetate	20-23	interleukin 1 beta	Homo sapiens	0-8
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	62-93	cyclin dependent kinase inhibitor 1A	Homo sapiens	206-210
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	62-93	cyclin dependent kinase inhibitor 1A	Homo sapiens	211-215
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	95-98	cyclin dependent kinase inhibitor 1A	Homo sapiens	202-205
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	95-98	cyclin dependent kinase inhibitor 1A	Homo sapiens	206-210
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	95-98	cyclin dependent kinase inhibitor 1A	Homo sapiens	211-215
17140607-5	2007	The maximal increase in Nav 1.8 currents was seen at 0.1microM after the application of a PKC activator, phorbol 12-myristate 13-acetate (PMA) and forskolin.	Tetradecanoylphorbol Acetate	105-136	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	24-31
17140607-5	2007	The maximal increase in Nav 1.8 currents was seen at 0.1microM after the application of a PKC activator, phorbol 12-myristate 13-acetate (PMA) and forskolin.	Tetradecanoylphorbol Acetate	138-141	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	24-31
17140607-7	2007	Intracellular application of a PKA inhibitor, protein kinase inhibitor (PKI, 0.01mM), inhibited the baseline Nav 1.8 current, significantly attenuated the 8-Br-cAMP-and PMA-induced increase in the peak Nav 1.8 current, and caused a significant increase in the slope factor of the inactivation curve.	Tetradecanoylphorbol Acetate	169-172	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	202-209
17325208-5	2007	Activation of PPARgamma1 wild type, but not an agonist-binding mutant of PPARgamma1, attenuated PMA-mediated PKCalpha cytosol to membrane translocation.	Tetradecanoylphorbol Acetate	96-99	protein kinase C alpha	Homo sapiens	109-117
17334233-0	2007	PMA-induced up-regulation of MMP-9 is regulated by a PKCalpha-NF-kappaB cascade in human lung epithelial cells.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	53-61
17334233-3	2007	In this study, we show that phorbol myristate acetate (PMA) induces MMP-9 expression via a protein kinase Calpha (PKCalpha)-dependent signaling cascade in BEAS-2B human lung epithelial cells.	Tetradecanoylphorbol Acetate	28-53	protein kinase C alpha	Homo sapiens	114-122
17334233-3	2007	In this study, we show that phorbol myristate acetate (PMA) induces MMP-9 expression via a protein kinase Calpha (PKCalpha)-dependent signaling cascade in BEAS-2B human lung epithelial cells.	Tetradecanoylphorbol Acetate	55-58	protein kinase C alpha	Homo sapiens	114-122
17334233-4	2007	Pretreatment with either GF109203X, a general PKC inhibitor, or Go6976, a PKCalpha/beta isozyme inhibitor, inhibited PMA-induced activation of the MMP-9 promoter, as did transient transfection with PKCalpha antisense oligonuclotides.	Tetradecanoylphorbol Acetate	117-120	protein kinase C alpha	Homo sapiens	46-49
17334233-4	2007	Pretreatment with either GF109203X, a general PKC inhibitor, or Go6976, a PKCalpha/beta isozyme inhibitor, inhibited PMA-induced activation of the MMP-9 promoter, as did transient transfection with PKCalpha antisense oligonuclotides.	Tetradecanoylphorbol Acetate	117-120	protein kinase C alpha	Homo sapiens	74-82
17334233-4	2007	Pretreatment with either GF109203X, a general PKC inhibitor, or Go6976, a PKCalpha/beta isozyme inhibitor, inhibited PMA-induced activation of the MMP-9 promoter, as did transient transfection with PKCalpha antisense oligonuclotides.	Tetradecanoylphorbol Acetate	117-120	protein kinase C alpha	Homo sapiens	198-206
17355198-4	2007	The algorithm successfully quantified phorbol 12-myristate 13-acetate (PMA)-induced plasma membrane localization of PKCalpha in HeLa cells (Z" of 0.88).	Tetradecanoylphorbol Acetate	38-69	protein kinase C alpha	Homo sapiens	116-124
17182622-4	2007	Klk8 mRNA as well as Klk6 and Klk7 mRNA were up-regulated after 12-O-tetradecanoylphorbol-13-acetate application in the WT mice.	Tetradecanoylphorbol Acetate	64-100	kallikrein related-peptidase 8	Mus musculus	0-4
17182622-4	2007	Klk8 mRNA as well as Klk6 and Klk7 mRNA were up-regulated after 12-O-tetradecanoylphorbol-13-acetate application in the WT mice.	Tetradecanoylphorbol Acetate	64-100	kallikrein related-peptidase 7 (chymotryptic, stratum corneum)	Mus musculus	30-34
17355198-4	2007	The algorithm successfully quantified phorbol 12-myristate 13-acetate (PMA)-induced plasma membrane localization of PKCalpha in HeLa cells (Z" of 0.88).	Tetradecanoylphorbol Acetate	71-74	protein kinase C alpha	Homo sapiens	116-124
17151701-6	2007	TPA downregulates BIM(EL) by extracellular signal-regulated kinase (ERK)-mediated BIM phosphorylation and further proteasome-mediated degradation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	29-66
17103408-7	2007	A significant increase in Th1 and Th2 CD4+ T cells was observed in the patients after ex vivo stimulation with phorbol 12-myristate 13-acetate /ionomycin.	Tetradecanoylphorbol Acetate	111-142	CD4 molecule	Homo sapiens	38-41
16950795-4	2007	Since NF-kappaB is known to regulate COX-2 gene expression, we determined the effect of 9Z,11E-CLA on TPA-induced activation of this transcription factor.	Tetradecanoylphorbol Acetate	102-105	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	6-15
16950795-5	2007	Treatment of mouse skin with 9Z,11E-CLA reduced TPA-induced DNA binding as well as nuclear translocation of NF-kappaB by blocking phosphorylation and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	48-51	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	176-188
16950795-6	2007	In addition, 9Z,11E-CLA attenuated TPA-induced phosphorylation of extracellular signal-regulated protein kinase, p38 mitogen-activated protein kinase and Akt.	Tetradecanoylphorbol Acetate	35-38	thymoma viral proto-oncogene 1	Mus musculus	154-157
16950795-7	2007	To further elucidate the molecular mechanism underlying the inactivation of NF-kappaB by 9Z,11E-CLA, we investigated its effect on TPA-induced activation of IkappaB kinase (IKK), an upstream kinase that regulates NF-kappaB via phosphorylation and degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	131-134	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-85
16950795-9	2007	Co-treatment of mouse skin with the IKKbeta-specific inhibitor SC-514 (1 micromol) attenuated TPA-induced activation of Akt and NF-kappaB, and also the expression of COX-2 in hairless mouse skin.	Tetradecanoylphorbol Acetate	94-97	thymoma viral proto-oncogene 1	Mus musculus	120-123
16950795-9	2007	Co-treatment of mouse skin with the IKKbeta-specific inhibitor SC-514 (1 micromol) attenuated TPA-induced activation of Akt and NF-kappaB, and also the expression of COX-2 in hairless mouse skin.	Tetradecanoylphorbol Acetate	94-97	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	128-137
16950795-10	2007	Taken together, 9Z,11E-CLA inhibits NF-kappaB driven-COX-2 expression by blocking the IKK and PI3K-Akt signaling in TPA-treated hairless mouse skin in vivo, which may account for its previously reported anti-tumor promoting effects.	Tetradecanoylphorbol Acetate	116-119	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	36-45
16950795-10	2007	Taken together, 9Z,11E-CLA inhibits NF-kappaB driven-COX-2 expression by blocking the IKK and PI3K-Akt signaling in TPA-treated hairless mouse skin in vivo, which may account for its previously reported anti-tumor promoting effects.	Tetradecanoylphorbol Acetate	116-119	thymoma viral proto-oncogene 1	Mus musculus	99-102
17151701-6	2007	TPA downregulates BIM(EL) by extracellular signal-regulated kinase (ERK)-mediated BIM phosphorylation and further proteasome-mediated degradation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	68-71
16861707-4	2007	T-cell surface expression of CD40L was evaluated using two-colour flow cytometry in (i) the resting state and (ii) following stimulation with phorbol myristate acetate/ionomycin, with or without ciclosporin (CsA)-mediated inhibition.	Tetradecanoylphorbol Acetate	142-167	CD40 ligand	Homo sapiens	29-34
17101779-4	2007	Here we show that stimulation by tetradecanoyl phorbol acetate (TPA) attenuates PPARgamma"s activity in a MEK-dependent manner, even when Ser84 is mutated to Ala. To elucidate the mechanism of attenuation, we found that PPARgamma directly interacts with MEKs, which are the activators of ERKs, but not with ERKs themselves, both in vivo and in vitro.	Tetradecanoylphorbol Acetate	33-62	peroxisome proliferator activated receptor gamma	Homo sapiens	80-89
17101779-4	2007	Here we show that stimulation by tetradecanoyl phorbol acetate (TPA) attenuates PPARgamma"s activity in a MEK-dependent manner, even when Ser84 is mutated to Ala. To elucidate the mechanism of attenuation, we found that PPARgamma directly interacts with MEKs, which are the activators of ERKs, but not with ERKs themselves, both in vivo and in vitro.	Tetradecanoylphorbol Acetate	33-62	mitogen-activated protein kinase kinase 7	Homo sapiens	106-109
17101779-4	2007	Here we show that stimulation by tetradecanoyl phorbol acetate (TPA) attenuates PPARgamma"s activity in a MEK-dependent manner, even when Ser84 is mutated to Ala. To elucidate the mechanism of attenuation, we found that PPARgamma directly interacts with MEKs, which are the activators of ERKs, but not with ERKs themselves, both in vivo and in vitro.	Tetradecanoylphorbol Acetate	33-62	peroxisome proliferator activated receptor gamma	Homo sapiens	220-229
17101779-4	2007	Here we show that stimulation by tetradecanoyl phorbol acetate (TPA) attenuates PPARgamma"s activity in a MEK-dependent manner, even when Ser84 is mutated to Ala. To elucidate the mechanism of attenuation, we found that PPARgamma directly interacts with MEKs, which are the activators of ERKs, but not with ERKs themselves, both in vivo and in vitro.	Tetradecanoylphorbol Acetate	33-62	mitogen-activated protein kinase 1	Homo sapiens	288-292
17101779-4	2007	Here we show that stimulation by tetradecanoyl phorbol acetate (TPA) attenuates PPARgamma"s activity in a MEK-dependent manner, even when Ser84 is mutated to Ala. To elucidate the mechanism of attenuation, we found that PPARgamma directly interacts with MEKs, which are the activators of ERKs, but not with ERKs themselves, both in vivo and in vitro.	Tetradecanoylphorbol Acetate	33-62	mitogen-activated protein kinase 1	Homo sapiens	307-311
17101779-4	2007	Here we show that stimulation by tetradecanoyl phorbol acetate (TPA) attenuates PPARgamma"s activity in a MEK-dependent manner, even when Ser84 is mutated to Ala. To elucidate the mechanism of attenuation, we found that PPARgamma directly interacts with MEKs, which are the activators of ERKs, but not with ERKs themselves, both in vivo and in vitro.	Tetradecanoylphorbol Acetate	64-67	peroxisome proliferator activated receptor gamma	Homo sapiens	80-89
17101779-4	2007	Here we show that stimulation by tetradecanoyl phorbol acetate (TPA) attenuates PPARgamma"s activity in a MEK-dependent manner, even when Ser84 is mutated to Ala. To elucidate the mechanism of attenuation, we found that PPARgamma directly interacts with MEKs, which are the activators of ERKs, but not with ERKs themselves, both in vivo and in vitro.	Tetradecanoylphorbol Acetate	64-67	mitogen-activated protein kinase kinase 7	Homo sapiens	106-109
17101779-4	2007	Here we show that stimulation by tetradecanoyl phorbol acetate (TPA) attenuates PPARgamma"s activity in a MEK-dependent manner, even when Ser84 is mutated to Ala. To elucidate the mechanism of attenuation, we found that PPARgamma directly interacts with MEKs, which are the activators of ERKs, but not with ERKs themselves, both in vivo and in vitro.	Tetradecanoylphorbol Acetate	64-67	peroxisome proliferator activated receptor gamma	Homo sapiens	220-229
17101779-4	2007	Here we show that stimulation by tetradecanoyl phorbol acetate (TPA) attenuates PPARgamma"s activity in a MEK-dependent manner, even when Ser84 is mutated to Ala. To elucidate the mechanism of attenuation, we found that PPARgamma directly interacts with MEKs, which are the activators of ERKs, but not with ERKs themselves, both in vivo and in vitro.	Tetradecanoylphorbol Acetate	64-67	mitogen-activated protein kinase 1	Homo sapiens	288-292
17101779-4	2007	Here we show that stimulation by tetradecanoyl phorbol acetate (TPA) attenuates PPARgamma"s activity in a MEK-dependent manner, even when Ser84 is mutated to Ala. To elucidate the mechanism of attenuation, we found that PPARgamma directly interacts with MEKs, which are the activators of ERKs, but not with ERKs themselves, both in vivo and in vitro.	Tetradecanoylphorbol Acetate	64-67	mitogen-activated protein kinase 1	Homo sapiens	307-311
17101779-6	2007	Immunofluorescence microscopy and subcellular fractionation revealed that MEK1 exports PPARgamma from the nucleus, and this finding was supported by small interfering RNA knockdown of MEK1 and use of a cell-permeable interaction-blocking peptide, which prevented TPA-induced export of PPARgamma from the nucleus.	Tetradecanoylphorbol Acetate	263-266	peroxisome proliferator activated receptor gamma	Homo sapiens	87-96
17126953-6	2007	In addition, pretreatment with PS/PC liposomes also significantly reduced LPS/PMA-induced microglial NO production.	Tetradecanoylphorbol Acetate	78-81	surfactant protein C	Homo sapiens	31-36
17055343-4	2007	The effects of pioglitazone and resveratrol were reversed by pretreatment of THP-1 cells with a PPARgamma antagonist, GW9662, prior to PMA induction.	Tetradecanoylphorbol Acetate	135-138	GLI family zinc finger 2	Homo sapiens	77-82
17208252-3	2007	Neutrophils from zebrafish kidneys released neutrophil extracellular traps (NETs) and myeloperoxidase (MPO) upon stimulation with calcium ionophore, phorbol myristate acetate, and beta-glucan.	Tetradecanoylphorbol Acetate	149-174	myeloid-specific peroxidase	Danio rerio	86-101
17208252-3	2007	Neutrophils from zebrafish kidneys released neutrophil extracellular traps (NETs) and myeloperoxidase (MPO) upon stimulation with calcium ionophore, phorbol myristate acetate, and beta-glucan.	Tetradecanoylphorbol Acetate	149-174	myeloid-specific peroxidase	Danio rerio	103-106
17239241-10	2007	The inhibitory effect of IL-10 on tartrate-resistant acid phosphatase-positive cell number and NFATc1 mRNA expression was reversed by the protein kinase C agonist phorbol myristate acetate, providing evidence that interleukin-10 disrupts NFATc1 activity through its effect on Ca2+ mobilisation.	Tetradecanoylphorbol Acetate	163-188	interleukin 10	Mus musculus	25-30
17113069-4	2007	Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P&lt;0.05).	Tetradecanoylphorbol Acetate	72-103	tumor necrosis factor	Homo sapiens	179-212
17113069-4	2007	Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P&lt;0.05).	Tetradecanoylphorbol Acetate	72-103	interleukin 6	Homo sapiens	214-232
17113069-4	2007	Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P&lt;0.05).	Tetradecanoylphorbol Acetate	72-103	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
17113069-4	2007	Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P&lt;0.05).	Tetradecanoylphorbol Acetate	105-108	tumor necrosis factor	Homo sapiens	179-212
17113069-4	2007	Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P&lt;0.05).	Tetradecanoylphorbol Acetate	105-108	interleukin 6	Homo sapiens	214-232
17113069-4	2007	Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P&lt;0.05).	Tetradecanoylphorbol Acetate	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	238-242
17228877-4	2007	In addition, the compound inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity with human bladder carcinoma cells (T24 cells), and TPA-induced nuclear factor-kappa B (NF-kappaB) activity with human hepatocellular liver carcinoma cells (HepG2 cells).	Tetradecanoylphorbol Acetate	73-76	nuclear factor kappa B subunit 1	Homo sapiens	213-222
16832347-0	2007	Phorbol 12-myristate 13-acetate and serum synergize to promote rapamycin-insensitive cell proliferation via protein kinase C-eta.	Tetradecanoylphorbol Acetate	0-31	protein kinase C eta	Homo sapiens	108-128
16832347-3	2007	In U-251MG cells, rapamycin (10 nM) treatment was less effective as an antiproliferative agent when cells were concurrently stimulated with 10% serum and phorbol 12-myristate 13-acetate (PMA, 100 nM), a potent activator of PKC isozymes.	Tetradecanoylphorbol Acetate	154-185	protein kinase C eta	Homo sapiens	223-226
17239241-10	2007	The inhibitory effect of IL-10 on tartrate-resistant acid phosphatase-positive cell number and NFATc1 mRNA expression was reversed by the protein kinase C agonist phorbol myristate acetate, providing evidence that interleukin-10 disrupts NFATc1 activity through its effect on Ca2+ mobilisation.	Tetradecanoylphorbol Acetate	163-188	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	95-101
17239241-10	2007	The inhibitory effect of IL-10 on tartrate-resistant acid phosphatase-positive cell number and NFATc1 mRNA expression was reversed by the protein kinase C agonist phorbol myristate acetate, providing evidence that interleukin-10 disrupts NFATc1 activity through its effect on Ca2+ mobilisation.	Tetradecanoylphorbol Acetate	163-188	interleukin 10	Mus musculus	214-228
17239241-10	2007	The inhibitory effect of IL-10 on tartrate-resistant acid phosphatase-positive cell number and NFATc1 mRNA expression was reversed by the protein kinase C agonist phorbol myristate acetate, providing evidence that interleukin-10 disrupts NFATc1 activity through its effect on Ca2+ mobilisation.	Tetradecanoylphorbol Acetate	163-188	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	238-244
17114179-5	2007	Besides TNF, gamma-tocotrienol also abolished NF-kappaB activation induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke, interleukin-1beta, and epidermal growth factor.	Tetradecanoylphorbol Acetate	78-103	nuclear factor kappa B subunit 1	Homo sapiens	46-55
17091491-3	2007	The PKC activator, PMA, selectively increased the number of astrocytes, whereas it decreased the generation of neurons and oligodendrocytes.	Tetradecanoylphorbol Acetate	19-22	protein kinase C alpha	Homo sapiens	4-7
17200207-5	2007	In a transmembrane invasion assay, phorbol-12-myristate-13-acetate (100 nmol/L) increased the number of invaded HP75 cells, a process that was attenuated by PKC inhibitors, MMP-9 antibody, PKC-alpha siRNA, or PKC-delta siRNA.	Tetradecanoylphorbol Acetate	35-66	protein kinase C alpha	Homo sapiens	157-160
17200179-0	2007	Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	186-217	epidermal growth factor receptor	Homo sapiens	12-44
17200207-5	2007	In a transmembrane invasion assay, phorbol-12-myristate-13-acetate (100 nmol/L) increased the number of invaded HP75 cells, a process that was attenuated by PKC inhibitors, MMP-9 antibody, PKC-alpha siRNA, or PKC-delta siRNA.	Tetradecanoylphorbol Acetate	35-66	protein kinase C alpha	Homo sapiens	189-198
17404058-2	2007	This article investigated the effects of jaceosidin (4",5,7-trihydroxy-3",6-dimethoxyflavone) isolated from Artemisia argyi on the upregulation of COX-2 and MMP-9 induced by the tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA) in MCF10A human breast epithelial cells (MCF10A cells).	Tetradecanoylphorbol Acetate	193-229	prostaglandin-endoperoxide synthase 2	Homo sapiens	147-152
17200179-5	2007	Regarding downstream transduction, PMA-induced MUC5B expression was sensitive to inhibitors and dominant-negative expression of signaling molecules involved in Ras/mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase1-mediated c-Jun N-terminal kinase and p38 pathways.	Tetradecanoylphorbol Acetate	35-38	mitogen-activated protein kinase 14	Homo sapiens	287-290
17200179-7	2007	These results demonstrate for the first time that PMA-stimulated MUC5AC and MUC5B expressions are regulated through distinctive epidermal growth factor receptor/extracellular regulated kinase-dependent and -independent signaling pathways.	Tetradecanoylphorbol Acetate	50-53	epidermal growth factor receptor	Homo sapiens	128-160
17404063-5	2007	We found that EGCG inhibited TPA-induced DNA binding of NF-kappaB and CREB in mouse skin in vivo.	Tetradecanoylphorbol Acetate	29-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	56-65
17404068-6	2007	In this study, we found that KG-135 inhibited COX-2 expression in MCF-10A cells stimulated with a prototype tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	123-159	prostaglandin-endoperoxide synthase 2	Homo sapiens	46-51
17404063-5	2007	We found that EGCG inhibited TPA-induced DNA binding of NF-kappaB and CREB in mouse skin in vivo.	Tetradecanoylphorbol Acetate	29-32	cAMP responsive element binding protein 1	Mus musculus	70-74
17404058-2	2007	This article investigated the effects of jaceosidin (4",5,7-trihydroxy-3",6-dimethoxyflavone) isolated from Artemisia argyi on the upregulation of COX-2 and MMP-9 induced by the tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA) in MCF10A human breast epithelial cells (MCF10A cells).	Tetradecanoylphorbol Acetate	231-234	prostaglandin-endoperoxide synthase 2	Homo sapiens	147-152
17404063-6	2007	EGCG also suppressed TPA-induced phosphorylation and subsequent degradation of IkappaBalpha, and prevented nuclear translocation of p65.	Tetradecanoylphorbol Acetate	21-24	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	79-91
17404068-9	2007	In addition, KG-135 inhibited TPA-induced phosphorylation of c-Jun N-terminal kinases (JNK) that regulates COX-2 expression in MCF-10A cells.	Tetradecanoylphorbol Acetate	30-33	mitogen-activated protein kinase 8	Homo sapiens	61-85
17404058-3	2007	Treatment of MCF10A cells with TPA induced the upregulation of COX-2 and MMP-9, and this was attenuated by jaceosidin treatment.	Tetradecanoylphorbol Acetate	31-34	prostaglandin-endoperoxide synthase 2	Homo sapiens	63-68
17404068-9	2007	In addition, KG-135 inhibited TPA-induced phosphorylation of c-Jun N-terminal kinases (JNK) that regulates COX-2 expression in MCF-10A cells.	Tetradecanoylphorbol Acetate	30-33	mitogen-activated protein kinase 8	Homo sapiens	87-90
17404063-8	2007	Pretreatment with U0126 and SB203580, pharmacological inhibitors of ERK and p38 MAPK, respectively, showed that SB203580, but not U0126, attenuated TPA-induced CREB DNA binding in mouse skin.	Tetradecanoylphorbol Acetate	148-151	mitogen-activated protein kinase 1	Mus musculus	68-71
17404063-8	2007	Pretreatment with U0126 and SB203580, pharmacological inhibitors of ERK and p38 MAPK, respectively, showed that SB203580, but not U0126, attenuated TPA-induced CREB DNA binding in mouse skin.	Tetradecanoylphorbol Acetate	148-151	cAMP responsive element binding protein 1	Mus musculus	160-164
17404063-9	2007	Taken together, EGCG inhibited TPA-induced DNA binding of NF-kappaB and CREB by blocking activation of p38 MAPK, which may provide a molecular basis of COX-2 inhibition by EGCG in mouse skin in vivo.	Tetradecanoylphorbol Acetate	31-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	58-67
17404063-9	2007	Taken together, EGCG inhibited TPA-induced DNA binding of NF-kappaB and CREB by blocking activation of p38 MAPK, which may provide a molecular basis of COX-2 inhibition by EGCG in mouse skin in vivo.	Tetradecanoylphorbol Acetate	31-34	cAMP responsive element binding protein 1	Mus musculus	72-76
17404068-9	2007	In addition, KG-135 inhibited TPA-induced phosphorylation of c-Jun N-terminal kinases (JNK) that regulates COX-2 expression in MCF-10A cells.	Tetradecanoylphorbol Acetate	30-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	107-112
17404068-10	2007	The JNK inhibitor SP600125 attenuated COX-2 expression in TPA-treated MCF-10A cells.	Tetradecanoylphorbol Acetate	58-61	mitogen-activated protein kinase 8	Homo sapiens	4-7
17404068-10	2007	The JNK inhibitor SP600125 attenuated COX-2 expression in TPA-treated MCF-10A cells.	Tetradecanoylphorbol Acetate	58-61	prostaglandin-endoperoxide synthase 2	Homo sapiens	38-43
17404058-5	2007	Furthermore, jaceosidin blocked the TPA-induced phosphorylation of extracellular signal-regulated protein kinase-1 and -2 (ERK-1 and -2), which is one of the signaling molecules regulating COX-2 and MMP.	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase 3	Homo sapiens	123-135
17404058-5	2007	Furthermore, jaceosidin blocked the TPA-induced phosphorylation of extracellular signal-regulated protein kinase-1 and -2 (ERK-1 and -2), which is one of the signaling molecules regulating COX-2 and MMP.	Tetradecanoylphorbol Acetate	36-39	prostaglandin-endoperoxide synthase 2	Homo sapiens	189-194
17404068-11	2007	Taken together, the above findings suggest that KG-135 inhibits TPA-induced COX-2 expression in MCF-10A cells by blocking the JNK/AP-1 signaling pathway.	Tetradecanoylphorbol Acetate	64-67	prostaglandin-endoperoxide synthase 2	Homo sapiens	76-81
17404058-6	2007	These results suggest that jaceosidin inhibits the TPA-induced upregulation of COX-2 and MMP-9 by blocking ERK-1 and -2 phosphorylation in human breast epithelial cells, which may be indicative of its chemopreventive potential.	Tetradecanoylphorbol Acetate	51-54	prostaglandin-endoperoxide synthase 2	Homo sapiens	79-84
17404068-11	2007	Taken together, the above findings suggest that KG-135 inhibits TPA-induced COX-2 expression in MCF-10A cells by blocking the JNK/AP-1 signaling pathway.	Tetradecanoylphorbol Acetate	64-67	mitogen-activated protein kinase 8	Homo sapiens	126-129
17404064-5	2007	This article investigated the effect of peonidin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 expression and transformation in JB6 P(+) mouse epidermal cells (JB6 P(+) cells).	Tetradecanoylphorbol Acetate	52-88	prostaglandin-endoperoxide synthase 2	Homo sapiens	103-108
17404058-6	2007	These results suggest that jaceosidin inhibits the TPA-induced upregulation of COX-2 and MMP-9 by blocking ERK-1 and -2 phosphorylation in human breast epithelial cells, which may be indicative of its chemopreventive potential.	Tetradecanoylphorbol Acetate	51-54	mitogen-activated protein kinase 3	Homo sapiens	107-119
17404064-5	2007	This article investigated the effect of peonidin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 expression and transformation in JB6 P(+) mouse epidermal cells (JB6 P(+) cells).	Tetradecanoylphorbol Acetate	90-93	prostaglandin-endoperoxide synthase 2	Homo sapiens	103-108
17202682-5	2007	In addition, asiatic acid inhibited the TPA-induced generation of nitric oxide (NO) and expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), which are known to play important roles in tumor growth, especially in the promotion stage.	Tetradecanoylphorbol Acetate	40-43	nitric oxide synthase 2, inducible	Mus musculus	102-123
17404064-6	2007	Treatment of JB6 P(+) cells with peonidin inhibited TPA-induced COX-2 expression, and also decreased TPA-induced neoplastic transformation and blocked TPA-induced phosphorylation of extracellular signal-regulated kinases (ERKs) in the cells.	Tetradecanoylphorbol Acetate	52-55	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-69
17202682-5	2007	In addition, asiatic acid inhibited the TPA-induced generation of nitric oxide (NO) and expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), which are known to play important roles in tumor growth, especially in the promotion stage.	Tetradecanoylphorbol Acetate	40-43	nitric oxide synthase 2, inducible	Mus musculus	125-129
16774932-4	2007	The use of Ro-318220 and GO-6983, general PKC inhibitors as well as MG-132, a proteasome-specific inhibitor, abrogated PMA-induced degradation of IKK-gamma and recovered the activation of IKK by TNF, suggesting that IKK complex is predominantly degraded by the proteasome pathway in a PKC-dependent manner.	Tetradecanoylphorbol Acetate	119-122	tumor necrosis factor	Homo sapiens	195-198
16774932-1	2007	Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) triggers cellular signals that lead to the activation of the transcription factor NF-kappaB (nuclear factor kappaB) in various cell types.	Tetradecanoylphorbol Acetate	40-71	nuclear factor kappa B subunit 1	Homo sapiens	160-169
16774932-1	2007	Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) triggers cellular signals that lead to the activation of the transcription factor NF-kappaB (nuclear factor kappaB) in various cell types.	Tetradecanoylphorbol Acetate	40-71	nuclear factor kappa B subunit 1	Homo sapiens	171-192
17257442-5	2007	METHODS: We have studied plasminogen binding to MCF-7 in which urokinase plasminogen activator receptor (uPAR) levels were upregulated by PMA (12-O-tetradecanoylphorbol-13-acetate) stimulation, allowing flexible and transient modulation of cell-surface uPA.	Tetradecanoylphorbol Acetate	138-141	plasminogen activator, urokinase	Homo sapiens	105-108
17257442-5	2007	METHODS: We have studied plasminogen binding to MCF-7 in which urokinase plasminogen activator receptor (uPAR) levels were upregulated by PMA (12-O-tetradecanoylphorbol-13-acetate) stimulation, allowing flexible and transient modulation of cell-surface uPA.	Tetradecanoylphorbol Acetate	143-179	plasminogen activator, urokinase	Homo sapiens	105-108
17365014-6	2007	When using phorbol myristate acetate to stimulate the cells, NFkappaB and NO levels were unaffected by Echinacea or its components while only cichoric acid and 2 inhibited TNFalpha levels.	Tetradecanoylphorbol Acetate	11-36	nuclear factor kappa B subunit 1	Homo sapiens	61-69
17210708-2	2007	We have recently shown expression of RasGRP1 in the epidermal keratinocytes where it can mediate Ras activation in response to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, a well-known mouse skin tumor promoter.	Tetradecanoylphorbol Acetate	145-181	RAS guanyl releasing protein 1	Mus musculus	37-44
16774932-1	2007	Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) triggers cellular signals that lead to the activation of the transcription factor NF-kappaB (nuclear factor kappaB) in various cell types.	Tetradecanoylphorbol Acetate	73-76	nuclear factor kappa B subunit 1	Homo sapiens	160-169
16774932-1	2007	Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) triggers cellular signals that lead to the activation of the transcription factor NF-kappaB (nuclear factor kappaB) in various cell types.	Tetradecanoylphorbol Acetate	73-76	nuclear factor kappa B subunit 1	Homo sapiens	171-192
16774932-2	2007	In addition to NF-kappaB activation by short-time PMA treatment, here we report that the prolonged exposure of human colonic cancer epithelial cells treated with PMA can also lead to a persistent inhibition of NF-kappaB activation.	Tetradecanoylphorbol Acetate	50-53	nuclear factor kappa B subunit 1	Homo sapiens	15-24
16774932-2	2007	In addition to NF-kappaB activation by short-time PMA treatment, here we report that the prolonged exposure of human colonic cancer epithelial cells treated with PMA can also lead to a persistent inhibition of NF-kappaB activation.	Tetradecanoylphorbol Acetate	162-165	nuclear factor kappa B subunit 1	Homo sapiens	15-24
16774932-2	2007	In addition to NF-kappaB activation by short-time PMA treatment, here we report that the prolonged exposure of human colonic cancer epithelial cells treated with PMA can also lead to a persistent inhibition of NF-kappaB activation.	Tetradecanoylphorbol Acetate	162-165	nuclear factor kappa B subunit 1	Homo sapiens	210-219
16774932-3	2007	PMA selectively causes the degradation of IkappaB kinases (IKKs) including IKK-gamma and IKK-beta, and subsequent inhibition of tumor necrosis factor (TNF) induced IKK and NF-kappaB activation in human colon cancer cell line HCT-116, but not in other gastrointestinal tract cells.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	128-149
16774932-3	2007	PMA selectively causes the degradation of IkappaB kinases (IKKs) including IKK-gamma and IKK-beta, and subsequent inhibition of tumor necrosis factor (TNF) induced IKK and NF-kappaB activation in human colon cancer cell line HCT-116, but not in other gastrointestinal tract cells.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	151-154
16774932-3	2007	PMA selectively causes the degradation of IkappaB kinases (IKKs) including IKK-gamma and IKK-beta, and subsequent inhibition of tumor necrosis factor (TNF) induced IKK and NF-kappaB activation in human colon cancer cell line HCT-116, but not in other gastrointestinal tract cells.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	172-181
17334670-1	2007	OBJECTIVES: The differentiation of THP-1 monocytes into macrophages is mainly conducted at a phorbol 12-myristate 13-acetate (PMA) concentration of 10-400 ng/ml.	Tetradecanoylphorbol Acetate	93-124	GLI family zinc finger 2	Homo sapiens	35-40
17334670-1	2007	OBJECTIVES: The differentiation of THP-1 monocytes into macrophages is mainly conducted at a phorbol 12-myristate 13-acetate (PMA) concentration of 10-400 ng/ml.	Tetradecanoylphorbol Acetate	126-129	GLI family zinc finger 2	Homo sapiens	35-40
17460413-6	2007	beta1 Integrins mediated tubule formation to comparable levels in endothelial cells that were incubated with supernatants derived from uninduced or TPA-induced PEL cells.	Tetradecanoylphorbol Acetate	148-151	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	0-5
17438848-6	2007	The percentage of cells of active AP-1, IL-5 protein in supernatants of allergic rhinitis T lymphocytes stimulated with PMA and curcumin were significantly lower than those of allergic rhinitis T lymphocytes stimulated with PMA (P &lt; 0.01); but significantly higher than those of allergic rhinitis T lymphocytes stimulated without PMA and those of deflection of nasal septum T lymphocytes stimulated.	Tetradecanoylphorbol Acetate	120-123	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-38
16888805-0	2007	Interleukin-1beta and tetradecanoylphorbol acetate-induced biosynthesis of tumor necrosis factor alpha in human hepatoma cells involves the transcription factors ATF2 and c-Jun and stress-activated protein kinases.	Tetradecanoylphorbol Acetate	22-50	tumor necrosis factor	Homo sapiens	75-102
16888805-3	2007	In hepatocytes or human hepatoma cells TNFalpha is expressed at extremely low levels but TNFalpha biosynthesis can be induced by interleukin (IL)-1beta or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	155-191	tumor necrosis factor	Homo sapiens	89-97
16888805-3	2007	In hepatocytes or human hepatoma cells TNFalpha is expressed at extremely low levels but TNFalpha biosynthesis can be induced by interleukin (IL)-1beta or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	193-196	tumor necrosis factor	Homo sapiens	89-97
16888805-4	2007	Here, we show that IL-1beta and TPA stimulated TNFalpha gene transcription in hepatoma cells mediated by a composite TPA-responsive element/cAMP response element.	Tetradecanoylphorbol Acetate	32-35	tumor necrosis factor	Homo sapiens	47-55
16888805-4	2007	Here, we show that IL-1beta and TPA stimulated TNFalpha gene transcription in hepatoma cells mediated by a composite TPA-responsive element/cAMP response element.	Tetradecanoylphorbol Acetate	117-120	interleukin 1 beta	Homo sapiens	19-27
16888805-4	2007	Here, we show that IL-1beta and TPA stimulated TNFalpha gene transcription in hepatoma cells mediated by a composite TPA-responsive element/cAMP response element.	Tetradecanoylphorbol Acetate	117-120	tumor necrosis factor	Homo sapiens	47-55
16888805-5	2007	Both IL-1beta and TPA triggered phosphorylation and activation of the basic region leucine zipper transcription factors c-Jun and ATF2 and expression of dominant-negative mutants of c-Jun and ATF2-reduced TNFalpha promoter activity and secretion of TNFalpha.	Tetradecanoylphorbol Acetate	18-21	tumor necrosis factor	Homo sapiens	205-213
16888805-5	2007	Both IL-1beta and TPA triggered phosphorylation and activation of the basic region leucine zipper transcription factors c-Jun and ATF2 and expression of dominant-negative mutants of c-Jun and ATF2-reduced TNFalpha promoter activity and secretion of TNFalpha.	Tetradecanoylphorbol Acetate	18-21	tumor necrosis factor	Homo sapiens	249-257
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	153-156	dual specificity phosphatase 1	Homo sapiens	40-64
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	153-156	dual specificity phosphatase 1	Homo sapiens	66-71
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	153-156	tumor necrosis factor	Homo sapiens	81-89
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	153-156	tumor necrosis factor	Homo sapiens	112-120
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	153-156	dual specificity phosphatase 1	Homo sapiens	186-191
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	153-156	interleukin 1 beta	Homo sapiens	233-241
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	153-156	tumor necrosis factor	Homo sapiens	112-120
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	246-249	dual specificity phosphatase 1	Homo sapiens	40-64
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	246-249	dual specificity phosphatase 1	Homo sapiens	66-71
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	246-249	tumor necrosis factor	Homo sapiens	81-89
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	246-249	tumor necrosis factor	Homo sapiens	112-120
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	246-249	interleukin 1 beta	Homo sapiens	141-149
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	246-249	dual specificity phosphatase 1	Homo sapiens	186-191
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	246-249	interleukin 1 beta	Homo sapiens	233-241
16888805-6	2007	Expression of the nuclear dual-specific MAP kinase phosphatase-1 (MKP-1) blocked TNFalpha promoter activity and TNFalpha secretion following IL-1beta or TPA stimulation, indicating that MKP-1 functions as a nuclear shut-of-device of IL-1beta and TPA-induced TNFalpha expression.	Tetradecanoylphorbol Acetate	246-249	tumor necrosis factor	Homo sapiens	112-120
17130901-1	2007	Phospholipase D (PLD) is a ubiquitous enzyme that can be activated by extracellular adenosine 5"-triphosphate (ATP) or phorbol 12-myristate 13-acetate (PMA) in B-lymphocytes from subjects with chronic lymphocytic leukaemia (CLL).	Tetradecanoylphorbol Acetate	119-150	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
17130901-1	2007	Phospholipase D (PLD) is a ubiquitous enzyme that can be activated by extracellular adenosine 5"-triphosphate (ATP) or phorbol 12-myristate 13-acetate (PMA) in B-lymphocytes from subjects with chronic lymphocytic leukaemia (CLL).	Tetradecanoylphorbol Acetate	119-150	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
17130901-1	2007	Phospholipase D (PLD) is a ubiquitous enzyme that can be activated by extracellular adenosine 5"-triphosphate (ATP) or phorbol 12-myristate 13-acetate (PMA) in B-lymphocytes from subjects with chronic lymphocytic leukaemia (CLL).	Tetradecanoylphorbol Acetate	152-155	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-15
17130901-1	2007	Phospholipase D (PLD) is a ubiquitous enzyme that can be activated by extracellular adenosine 5"-triphosphate (ATP) or phorbol 12-myristate 13-acetate (PMA) in B-lymphocytes from subjects with chronic lymphocytic leukaemia (CLL).	Tetradecanoylphorbol Acetate	152-155	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
17005918-6	2007	NCX 6550 also significantly reduced phorbol 12-myristate 13-acetate-induced ROS production that was enhanced in isolated ApoE-/- splenocytes.	Tetradecanoylphorbol Acetate	36-67	apolipoprotein E	Mus musculus	121-125
17344653-9	2007	In accordance with adult data, the percentage of neonatal lymphocytes producing IL-2 after phorbol 12-myristate 13-acetate/ionomycin stimulation was dose-dependently reduced (e.g., 41.3% inhibition, p = 0.001, 20 mM vitamin C), while the percentage of TNF-alpha producing lymphocytes was mildly stimulated (e.g., 20.8% increase, p = 0.003, 20 mM vitamin C).	Tetradecanoylphorbol Acetate	91-122	interleukin 2	Homo sapiens	80-84
18094537-13	2007	On the other hand, an enzyme-linked immunoassay (EIA) showed that although PMA-treated U937 cells had strongly secreted soluble CD93 (sCD93) into the culture supernatant, the secretion of sCD93 in the culture supernatant of the U937 cells treated with the above-mentioned chemical substances was not enhanced, compared with that of untreated U937 cells.	Tetradecanoylphorbol Acetate	75-78	CD93 molecule	Homo sapiens	128-132
18094537-3	2007	We previously reported that a protein kinase C activator (PKC), phorbol myristate acetate (PMA), effectively up-regulated CD93 expression on several cultured cell lines and that its regulation was mainly controlled by a PKC delta-isoenzyme.	Tetradecanoylphorbol Acetate	64-89	CD93 molecule	Homo sapiens	122-126
18094537-3	2007	We previously reported that a protein kinase C activator (PKC), phorbol myristate acetate (PMA), effectively up-regulated CD93 expression on several cultured cell lines and that its regulation was mainly controlled by a PKC delta-isoenzyme.	Tetradecanoylphorbol Acetate	91-94	CD93 molecule	Homo sapiens	122-126
17518270-3	2007	Skin-specific E6/E7 transgenic mice showed approximately twice as many tumors compared with nontransgenic mice in dimethylbenz[a]anthracene (DMBA)-initiated and a 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted two-stage skin carcinogenesis.	Tetradecanoylphorbol Acetate	163-199	protein E6*;transforming protein E6	Human papillomavirus type 16	14-19
17518270-0	2007	DMBA/TPA-induced tumor formation is aggravated in human papillomavirus type 16 E6/E7 transgenic mouse skin.	Tetradecanoylphorbol Acetate	5-8	protein E6*;transforming protein E6	Human papillomavirus type 16	79-84
17143503-7	2007	Finally, TPA stimulated the activation of CREB and AP-1, but 6-MITC did not block TPA-induced COX-2 expression.	Tetradecanoylphorbol Acetate	9-12	cAMP responsive element binding protein 1	Mus musculus	42-46
17518270-3	2007	Skin-specific E6/E7 transgenic mice showed approximately twice as many tumors compared with nontransgenic mice in dimethylbenz[a]anthracene (DMBA)-initiated and a 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted two-stage skin carcinogenesis.	Tetradecanoylphorbol Acetate	201-204	protein E6*;transforming protein E6	Human papillomavirus type 16	14-19
17518270-6	2007	The overexpression of E6/E7 in the skin in the DMBA/TPA two-stage-induced carcinogenesis model aggravated the incidence of tumor formation.	Tetradecanoylphorbol Acetate	52-55	protein E6*;transforming protein E6	Human papillomavirus type 16	22-27
17518270-7	2007	HPV16 E6/E7 appears to act as an enhancer of carcinogenesis that requires initiation by DMBA and promotion by TPA.	Tetradecanoylphorbol Acetate	110-113	protein E6*;transforming protein E6	Human papillomavirus type 16	6-11
17512973-4	2007	Accordingly, VEGF-induced fibrinolysis correlated with an increase in the expression of tPA and of some MMPs, such as MT2-MMP and was completely blocked by a neutralizing antibody against tPA.	Tetradecanoylphorbol Acetate	88-91	vascular endothelial growth factor A	Homo sapiens	13-17
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	Tetradecanoylphorbol Acetate	18-49	tumor necrosis factor	Homo sapiens	133-160
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	Tetradecanoylphorbol Acetate	18-49	tumor necrosis factor	Homo sapiens	162-171
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	Tetradecanoylphorbol Acetate	18-49	interleukin 1 beta	Homo sapiens	174-196
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	Tetradecanoylphorbol Acetate	18-49	interleukin 4	Homo sapiens	198-202
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	Tetradecanoylphorbol Acetate	18-49	interleukin 6	Homo sapiens	204-208
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	Tetradecanoylphorbol Acetate	18-49	C-X-C motif chemokine ligand 8	Homo sapiens	214-218
17200786-0	2007	IL-4 modulates tissue factor expression by human B lymphocytes in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	78-103	interleukin 4	Homo sapiens	0-4
17512973-4	2007	Accordingly, VEGF-induced fibrinolysis correlated with an increase in the expression of tPA and of some MMPs, such as MT2-MMP and was completely blocked by a neutralizing antibody against tPA.	Tetradecanoylphorbol Acetate	188-191	vascular endothelial growth factor A	Homo sapiens	13-17
17062574-3	2006	Overexpression of DSCR1.4 significantly attenuated the induction of cyclooxygenase-2 (COX-2) expression by phorbol 12-myristate 13-acetate (PMA) via a calcineurin-independent mechanism.	Tetradecanoylphorbol Acetate	107-138	prostaglandin-endoperoxide synthase 2	Homo sapiens	68-84
17097050-3	2006	Inhibition of AMPK by compound C, a specific inhibitor of AMPK or small interfering RNA of AMPKalpha1 suppressed IL-2 production in Jurkat T cells and peripheral blood lymphocytes stimulated with PMA plus ionomycin (PMA/Io) or with monoclonal anti-CD3 plus anti-CD28.	Tetradecanoylphorbol Acetate	196-199	interleukin 2	Homo sapiens	113-117
17097050-4	2006	We then showed that AMPK inhibition reduced PMA/Io-induced IL-2 mRNA expression and IL-2 promoter activation.	Tetradecanoylphorbol Acetate	44-47	interleukin 2	Homo sapiens	59-63
17097050-4	2006	We then showed that AMPK inhibition reduced PMA/Io-induced IL-2 mRNA expression and IL-2 promoter activation.	Tetradecanoylphorbol Acetate	44-47	interleukin 2	Homo sapiens	84-88
17069861-4	2006	Furthermore, phorbol myristate acetate (PMA), a PKC stimulant, but not dibutyryl cyclic AMP, a protein kinase A stimulant, decreased the levels of HSP27.	Tetradecanoylphorbol Acetate	13-38	proline rich transmembrane protein 2	Homo sapiens	48-51
17069861-4	2006	Furthermore, phorbol myristate acetate (PMA), a PKC stimulant, but not dibutyryl cyclic AMP, a protein kinase A stimulant, decreased the levels of HSP27.	Tetradecanoylphorbol Acetate	40-43	proline rich transmembrane protein 2	Homo sapiens	48-51
18354269-9	2007	Stimulation of normal PB mononuclear cells with pokeweed mitogen and phorbol myristate acetate induced substantially higher Ror1 mRNA expression compared to unstimulated cultured cells.	Tetradecanoylphorbol Acetate	69-94	receptor tyrosine kinase like orphan receptor 1	Homo sapiens	124-128
17062574-3	2006	Overexpression of DSCR1.4 significantly attenuated the induction of cyclooxygenase-2 (COX-2) expression by phorbol 12-myristate 13-acetate (PMA) via a calcineurin-independent mechanism.	Tetradecanoylphorbol Acetate	107-138	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-91
17062574-3	2006	Overexpression of DSCR1.4 significantly attenuated the induction of cyclooxygenase-2 (COX-2) expression by phorbol 12-myristate 13-acetate (PMA) via a calcineurin-independent mechanism.	Tetradecanoylphorbol Acetate	140-143	prostaglandin-endoperoxide synthase 2	Homo sapiens	68-84
17062574-3	2006	Overexpression of DSCR1.4 significantly attenuated the induction of cyclooxygenase-2 (COX-2) expression by phorbol 12-myristate 13-acetate (PMA) via a calcineurin-independent mechanism.	Tetradecanoylphorbol Acetate	140-143	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-91
17184493-4	2006	In order to systematically investigate these effects at a cellular level, we investigated gene expression in phorbol myristate acetate (PMA)-activated and non-activated human THP-1 monocytes in response to statins using cDNA arrays.	Tetradecanoylphorbol Acetate	109-134	GLI family zinc finger 2	Homo sapiens	175-180
17187679-9	2006	Furthermore, TPA-induced S100A9 gene expression in HaCaT keratinocytes was blocked after the pharmacologic inhibition of PARP-1 with 1,5-isoquinolinediol (DiQ).	Tetradecanoylphorbol Acetate	13-16	poly(ADP-ribose) polymerase 1	Homo sapiens	121-127
16601754-1	2006	Phorbol-12-myristate-13-acetate (PMA) treatment induces erythroblastoma D2 cells kept in suspension to undergo RhoA-dependent contraction and to become proapoptotic, while attached cells are induced to differentiate accompanied by the reduction of RhoA activity.	Tetradecanoylphorbol Acetate	0-31	ras homolog family member A	Homo sapiens	111-115
16601754-1	2006	Phorbol-12-myristate-13-acetate (PMA) treatment induces erythroblastoma D2 cells kept in suspension to undergo RhoA-dependent contraction and to become proapoptotic, while attached cells are induced to differentiate accompanied by the reduction of RhoA activity.	Tetradecanoylphorbol Acetate	0-31	ras homolog family member A	Homo sapiens	248-252
16601754-1	2006	Phorbol-12-myristate-13-acetate (PMA) treatment induces erythroblastoma D2 cells kept in suspension to undergo RhoA-dependent contraction and to become proapoptotic, while attached cells are induced to differentiate accompanied by the reduction of RhoA activity.	Tetradecanoylphorbol Acetate	33-36	ras homolog family member A	Homo sapiens	111-115
16601754-1	2006	Phorbol-12-myristate-13-acetate (PMA) treatment induces erythroblastoma D2 cells kept in suspension to undergo RhoA-dependent contraction and to become proapoptotic, while attached cells are induced to differentiate accompanied by the reduction of RhoA activity.	Tetradecanoylphorbol Acetate	33-36	ras homolog family member A	Homo sapiens	248-252
17035093-4	2006	This cell subset also expressed TNF-alpha and IFN-gamma, under phorbol-myristate-acetate/ionomycin stimulation.	Tetradecanoylphorbol Acetate	63-88	tumor necrosis factor	Homo sapiens	32-41
17035093-4	2006	This cell subset also expressed TNF-alpha and IFN-gamma, under phorbol-myristate-acetate/ionomycin stimulation.	Tetradecanoylphorbol Acetate	63-88	interferon gamma	Homo sapiens	46-55
17184493-4	2006	In order to systematically investigate these effects at a cellular level, we investigated gene expression in phorbol myristate acetate (PMA)-activated and non-activated human THP-1 monocytes in response to statins using cDNA arrays.	Tetradecanoylphorbol Acetate	136-139	GLI family zinc finger 2	Homo sapiens	175-180
17022039-2	2006	PACAP-induced differentiation was inhibited by the phospholipase C inhibitor, U73122, the protein kinase C (PKC) inhibitor, chelerythrine, and the intracellular calcium chelator, BAPTA-AM, and was mimicked by phorbol 12-myristate 13-acetate (PMA), but not by 4alpha-PMA.	Tetradecanoylphorbol Acetate	209-240	adenylate cyclase activating polypeptide 1	Mus musculus	0-5
17053865-6	2006	By Western blotting, strong PKB/Akt activation was observed in the organ of Corti following exposure to 50 microM gentamicin for 6 h. In addition, PKC activation by 12-O-tetradecanoylphorbol-13-acetate protected outer hair cells from gentamicin induced cell death.	Tetradecanoylphorbol Acetate	165-201	AKT serine/threonine kinase 1	Rattus norvegicus	28-35
16940331-6	2006	PMA induced the phosphorylation of Akt at Ser-473 and Thr-308 and the phosphorylation of Akt substrates, independently of PI-3K in B-CLL cells.	Tetradecanoylphorbol Acetate	0-3	AKT serine/threonine kinase 1	Homo sapiens	35-38
16940331-6	2006	PMA induced the phosphorylation of Akt at Ser-473 and Thr-308 and the phosphorylation of Akt substrates, independently of PI-3K in B-CLL cells.	Tetradecanoylphorbol Acetate	0-3	AKT serine/threonine kinase 1	Homo sapiens	89-92
17170089-5	2006	PKC downregulation, obtained by long-term treatment with phorbol 12-myristate 13-acetate (PMA), resulted in promoter stimulation at similar levels in sub-confluent cells.	Tetradecanoylphorbol Acetate	57-88	protein kinase C alpha	Homo sapiens	0-3
17170089-5	2006	PKC downregulation, obtained by long-term treatment with phorbol 12-myristate 13-acetate (PMA), resulted in promoter stimulation at similar levels in sub-confluent cells.	Tetradecanoylphorbol Acetate	90-93	protein kinase C alpha	Homo sapiens	0-3
17348203-1	2006	In the present study, we measured the antibody-catalyzed 03 formation from THP-1 monocytes activated by phorbol myristate acetate (PMA) by indigo carmine bleaching reaction test, and the accumulation of cholesterol in THP-1 monocytes by fluorescence spectrophotometric method, and analyzed the cholesterol ozonation product 5,6-secosterol by high-performance liquid chromatography (HPLC), to explore the potential effect of antibody-catalyzed water oxidation on pathogenesis of atherosclerosis.	Tetradecanoylphorbol Acetate	104-129	GLI family zinc finger 2	Homo sapiens	75-80
17348203-1	2006	In the present study, we measured the antibody-catalyzed 03 formation from THP-1 monocytes activated by phorbol myristate acetate (PMA) by indigo carmine bleaching reaction test, and the accumulation of cholesterol in THP-1 monocytes by fluorescence spectrophotometric method, and analyzed the cholesterol ozonation product 5,6-secosterol by high-performance liquid chromatography (HPLC), to explore the potential effect of antibody-catalyzed water oxidation on pathogenesis of atherosclerosis.	Tetradecanoylphorbol Acetate	131-134	GLI family zinc finger 2	Homo sapiens	75-80
17348203-1	2006	In the present study, we measured the antibody-catalyzed 03 formation from THP-1 monocytes activated by phorbol myristate acetate (PMA) by indigo carmine bleaching reaction test, and the accumulation of cholesterol in THP-1 monocytes by fluorescence spectrophotometric method, and analyzed the cholesterol ozonation product 5,6-secosterol by high-performance liquid chromatography (HPLC), to explore the potential effect of antibody-catalyzed water oxidation on pathogenesis of atherosclerosis.	Tetradecanoylphorbol Acetate	131-134	GLI family zinc finger 2	Homo sapiens	218-223
17022039-2	2006	PACAP-induced differentiation was inhibited by the phospholipase C inhibitor, U73122, the protein kinase C (PKC) inhibitor, chelerythrine, and the intracellular calcium chelator, BAPTA-AM, and was mimicked by phorbol 12-myristate 13-acetate (PMA), but not by 4alpha-PMA.	Tetradecanoylphorbol Acetate	242-245	adenylate cyclase activating polypeptide 1	Mus musculus	0-5
17172432-6	2006	The TPA-induced mitogen-activated protein kinase (MAPK) activation cascade was also analyzed.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase 3	Homo sapiens	50-54
17030510-7	2006	PMA treatment resulted in transient activation of mitogen-activated protein kinases (ERK1/2, JNK1/2, and p38) followed by dephosphorylation/inactivation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	85-91
17030510-7	2006	PMA treatment resulted in transient activation of mitogen-activated protein kinases (ERK1/2, JNK1/2, and p38) followed by dephosphorylation/inactivation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	93-99
17030510-7	2006	PMA treatment resulted in transient activation of mitogen-activated protein kinases (ERK1/2, JNK1/2, and p38) followed by dephosphorylation/inactivation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	105-108
17008378-2	2006	Recently, we reported that phorbol-12-myristate-13-acetate (PMA) potently enhanced the current amplitude of Cav3.2 T-type channels reconstituted in Xenopus oocytes.	Tetradecanoylphorbol Acetate	27-58	caveolin 3, gene 2 S homeolog	Xenopus laevis	108-114
17008378-2	2006	Recently, we reported that phorbol-12-myristate-13-acetate (PMA) potently enhanced the current amplitude of Cav3.2 T-type channels reconstituted in Xenopus oocytes.	Tetradecanoylphorbol Acetate	60-63	caveolin 3, gene 2 S homeolog	Xenopus laevis	108-114
17172432-7	2006	Despite extensive activation of major MAPKs [c-Jun NH2-terminal kinase, p38, and extracellular signal-regulated kinase-1/2 (ERK1/2)] under TPA stimulation, only the ERK1/2 activation and its consequent nuclear translocation were found to be diminished by MIA.	Tetradecanoylphorbol Acetate	139-142	mitogen-activated protein kinase 1	Homo sapiens	81-122
17172432-7	2006	Despite extensive activation of major MAPKs [c-Jun NH2-terminal kinase, p38, and extracellular signal-regulated kinase-1/2 (ERK1/2)] under TPA stimulation, only the ERK1/2 activation and its consequent nuclear translocation were found to be diminished by MIA.	Tetradecanoylphorbol Acetate	139-142	mitogen-activated protein kinase 3	Homo sapiens	124-130
17438683-9	2006	The levels of IL-10, and especially IL-2 were elevated by TPA, but they were markedly lower than that in control group after PD098059 pretreatment.	Tetradecanoylphorbol Acetate	58-61	interleukin 10	Mus musculus	14-19
17159800-7	2006	The chemiluminescence signal, initiated by phorbol-12-myristate-13-acetate, was enhanced either with isoluminol (extracellular) or with luminol in the presence of extracellular scavengers, superoxide dismutase and catalase (intracellular).	Tetradecanoylphorbol Acetate	43-74	catalase	Homo sapiens	214-222
17085321-3	2006	Phorbol myristate acetate (PMA) and calcium ionophore, A23187 further enhanced PGE(2) synthesis (p&lt;0.001) and caused phosphorylation of ERK that was sustained for up to 16 h. COX-2 protein expression and PGE(2) synthesis were increased following exposure to combinations of stimuli that increased intracellular Ca(2+), and activated protein kinase C as well as ERK.	Tetradecanoylphorbol Acetate	0-25	mitogen-activated protein kinase 1	Homo sapiens	139-142
17085321-3	2006	Phorbol myristate acetate (PMA) and calcium ionophore, A23187 further enhanced PGE(2) synthesis (p&lt;0.001) and caused phosphorylation of ERK that was sustained for up to 16 h. COX-2 protein expression and PGE(2) synthesis were increased following exposure to combinations of stimuli that increased intracellular Ca(2+), and activated protein kinase C as well as ERK.	Tetradecanoylphorbol Acetate	0-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
17085321-3	2006	Phorbol myristate acetate (PMA) and calcium ionophore, A23187 further enhanced PGE(2) synthesis (p&lt;0.001) and caused phosphorylation of ERK that was sustained for up to 16 h. COX-2 protein expression and PGE(2) synthesis were increased following exposure to combinations of stimuli that increased intracellular Ca(2+), and activated protein kinase C as well as ERK.	Tetradecanoylphorbol Acetate	0-25	mitogen-activated protein kinase 1	Homo sapiens	364-367
17085321-3	2006	Phorbol myristate acetate (PMA) and calcium ionophore, A23187 further enhanced PGE(2) synthesis (p&lt;0.001) and caused phosphorylation of ERK that was sustained for up to 16 h. COX-2 protein expression and PGE(2) synthesis were increased following exposure to combinations of stimuli that increased intracellular Ca(2+), and activated protein kinase C as well as ERK.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Homo sapiens	139-142
17085321-3	2006	Phorbol myristate acetate (PMA) and calcium ionophore, A23187 further enhanced PGE(2) synthesis (p&lt;0.001) and caused phosphorylation of ERK that was sustained for up to 16 h. COX-2 protein expression and PGE(2) synthesis were increased following exposure to combinations of stimuli that increased intracellular Ca(2+), and activated protein kinase C as well as ERK.	Tetradecanoylphorbol Acetate	27-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	178-183
17085321-3	2006	Phorbol myristate acetate (PMA) and calcium ionophore, A23187 further enhanced PGE(2) synthesis (p&lt;0.001) and caused phosphorylation of ERK that was sustained for up to 16 h. COX-2 protein expression and PGE(2) synthesis were increased following exposure to combinations of stimuli that increased intracellular Ca(2+), and activated protein kinase C as well as ERK.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Homo sapiens	364-367
16999939-7	2006	Among the MAP kinases, extracellular signal-regulated protein kinase (ERK) and p38 MAP kinase have been shown to regulate TPA-induced NF-kappaB activation, while p38 MAP kinase and c-Jun-N-terminal kinase are preferentially involved in TPA-induced activation of AP-1 in mouse skin in vivo.	Tetradecanoylphorbol Acetate	122-125	mitogen-activated protein kinase 1	Mus musculus	23-68
16999939-7	2006	Among the MAP kinases, extracellular signal-regulated protein kinase (ERK) and p38 MAP kinase have been shown to regulate TPA-induced NF-kappaB activation, while p38 MAP kinase and c-Jun-N-terminal kinase are preferentially involved in TPA-induced activation of AP-1 in mouse skin in vivo.	Tetradecanoylphorbol Acetate	122-125	mitogen-activated protein kinase 1	Mus musculus	70-73
16999939-7	2006	Among the MAP kinases, extracellular signal-regulated protein kinase (ERK) and p38 MAP kinase have been shown to regulate TPA-induced NF-kappaB activation, while p38 MAP kinase and c-Jun-N-terminal kinase are preferentially involved in TPA-induced activation of AP-1 in mouse skin in vivo.	Tetradecanoylphorbol Acetate	236-239	mitogen-activated protein kinase 1	Mus musculus	23-68
16999939-7	2006	Among the MAP kinases, extracellular signal-regulated protein kinase (ERK) and p38 MAP kinase have been shown to regulate TPA-induced NF-kappaB activation, while p38 MAP kinase and c-Jun-N-terminal kinase are preferentially involved in TPA-induced activation of AP-1 in mouse skin in vivo.	Tetradecanoylphorbol Acetate	236-239	mitogen-activated protein kinase 1	Mus musculus	70-73
17438683-12	2006	TPA and A23187 can markedly rectify the disturbance of IL-2/IL-10 secretion ratio by increasing the IL-2 secretion after scald.	Tetradecanoylphorbol Acetate	0-3	interleukin 10	Mus musculus	60-65
17116247-0	2006	Intensive post-operative follow-up of breast cancer patients with tumour markers: CEA, TPA or CA15.3 vs MCA and MCA-CA15.3 vs CEA-TPA-CA15.3 panel in the early detection of distant metastases.	Tetradecanoylphorbol Acetate	130-133	CEA cell adhesion molecule 3	Homo sapiens	126-129
17116247-2	2006	Differently, we observed that CEA-TPA-CA15.3 (carcinoembryonic (CEA) tissue polypeptide (TPA) and cancer associated 115D8/DF3 (CA15.3) antigens) panel permits early detection and treatment for most relapsing patients.	Tetradecanoylphorbol Acetate	34-37	CEA cell adhesion molecule 3	Homo sapiens	30-33
17116247-14	2006	Overall, CEA-TPA-CA15.3 panel is more accurate than MCA-CA15.3 association and can "early" detect a few relapsed patients with limited metastatic disease and more favourable prognosis.	Tetradecanoylphorbol Acetate	13-16	CEA cell adhesion molecule 3	Homo sapiens	9-12
17116247-2	2006	Differently, we observed that CEA-TPA-CA15.3 (carcinoembryonic (CEA) tissue polypeptide (TPA) and cancer associated 115D8/DF3 (CA15.3) antigens) panel permits early detection and treatment for most relapsing patients.	Tetradecanoylphorbol Acetate	34-37	CEA cell adhesion molecule 3	Homo sapiens	64-67
17116247-2	2006	Differently, we observed that CEA-TPA-CA15.3 (carcinoembryonic (CEA) tissue polypeptide (TPA) and cancer associated 115D8/DF3 (CA15.3) antigens) panel permits early detection and treatment for most relapsing patients.	Tetradecanoylphorbol Acetate	89-92	CEA cell adhesion molecule 3	Homo sapiens	30-33
17116247-3	2006	As high sensitivity and specificity and different cut-off values have been reported for mucin-like carcinoma associated antigen (MCA), we compared MCA with the above mentioned tumour markers and MCA-CA15.3 with the CEA-TPA-CA15.3 panel.	Tetradecanoylphorbol Acetate	219-222	CEA cell adhesion molecule 3	Homo sapiens	215-218
17116247-10	2006	Sensitivity of CEA-TPA-CA15.3 panel was 74% (14 of 19 recurrences).	Tetradecanoylphorbol Acetate	19-22	CEA cell adhesion molecule 3	Homo sapiens	15-18
17116247-11	2006	Eight of the 14 recurrences early detected with CEA-TPA-CA15.3 presented as a single lesion (oligometastatic disease) (5) or were confined to bony skeleton (3) (26% and 16% respectively of the 19 relapses).	Tetradecanoylphorbol Acetate	52-55	CEA cell adhesion molecule 3	Homo sapiens	48-51
17082637-3	2006	In this study, we report that TNF-alpha stimulates the expression of the FRA-1 protooncogene in human pulmonary epithelial cells using c-Jun, acting via a 12-O-tetradecanoylphorbol-13 acetate response element located at -318.	Tetradecanoylphorbol Acetate	155-191	tumor necrosis factor	Homo sapiens	30-39
17108111-0	2006	Mutant p53 protects cells from 12-O-tetradecanoylphorbol-13-acetate-induced death by attenuating activating transcription factor 3 induction.	Tetradecanoylphorbol Acetate	31-67	tumor protein p53	Homo sapiens	7-10
17108111-3	2006	In this study, we explore how the status of p53 affects the immediate response gene activating transcription factor 3 (ATF3) in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-protein kinase C (PKC) pathway.	Tetradecanoylphorbol Acetate	132-168	tumor protein p53	Homo sapiens	44-47
17108111-3	2006	In this study, we explore how the status of p53 affects the immediate response gene activating transcription factor 3 (ATF3) in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-protein kinase C (PKC) pathway.	Tetradecanoylphorbol Acetate	170-173	tumor protein p53	Homo sapiens	44-47
17108111-4	2006	We show that high doses of TPA induce ATF3 in a WT p53-independent manner correlating with PKCs depletion and cell death.	Tetradecanoylphorbol Acetate	27-30	tumor protein p53	Homo sapiens	51-54
17108111-5	2006	We show that cells harboring mutant p53 have attenuated ATF3 induction and are less sensitive to TPA-induced death compared with their p53-null counterparts.	Tetradecanoylphorbol Acetate	97-100	tumor protein p53	Homo sapiens	36-39
17108111-6	2006	Mutagenesis analysis of the ATF3 promoter identified the regulatory motifs cyclic AMP-responsive element binding protein/ATF and MEF2 as being responsible for the TPA-induced activation of ATF3.	Tetradecanoylphorbol Acetate	163-166	glial cell derived neurotrophic factor	Homo sapiens	28-31
16984800-3	2006	Preincubation of celastrol completely blocked the LPS-, TNF-alpha-, or PMA-induced degradation and phosphorylation of I kappa B alpha.	Tetradecanoylphorbol Acetate	71-74	NFKB inhibitor alpha	Homo sapiens	118-133
17078618-4	2006	The TCF-type acceptor with a phenyl group can lead to a larger TPA cross section.	Tetradecanoylphorbol Acetate	63-66	hepatocyte nuclear factor 4 alpha	Homo sapiens	4-7
16996475-8	2006	Analyses of PKC isoforms suggest that CREB phosphorylation is mediated by PKC epsilon translocating into nucleus only with TPA stimulation.	Tetradecanoylphorbol Acetate	123-126	cAMP responsive element binding protein 1	Mus musculus	38-42
17078618-7	2006	The calculations show that ferrocenyl derivatives with TCF-type acceptors (especially quadrupole molecules) are promising candidates for TPA materials.	Tetradecanoylphorbol Acetate	137-140	hepatocyte nuclear factor 4 alpha	Homo sapiens	55-58
16950767-3	2006	We report that COX-2 expression is up-regulated in phorbol ester (phorbol myristate acetate, PMA)-differentiated human U937 macrophage-like cells stimulated with lipopolysaccharide (LPS), whereas COX-1 is not up-regulated.	Tetradecanoylphorbol Acetate	66-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
16950767-3	2006	We report that COX-2 expression is up-regulated in phorbol ester (phorbol myristate acetate, PMA)-differentiated human U937 macrophage-like cells stimulated with lipopolysaccharide (LPS), whereas COX-1 is not up-regulated.	Tetradecanoylphorbol Acetate	93-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-20
17013757-7	2006	In addition, PKC inhibitor GF-109203X treatment blocks TPA-induced ERKs and JNKs protein phosphorylation, which indicates that activation of PKC locates at upstream of MAPKs activation in TPA-treated HL-60 cells.	Tetradecanoylphorbol Acetate	55-58	protein kinase C alpha	Homo sapiens	13-16
17049124-5	2006	RESULTS: The peptide has the ability to interact with the NF-kappaB p50 subunit and can effectively inhibit TNF-alpha and IL-6 production in the THP-1 cell line, PMA-induced ear edema and zymosan A-induced peritonitis in mice.	Tetradecanoylphorbol Acetate	162-165	nuclear factor kappa B subunit 1	Homo sapiens	58-71
17049124-5	2006	RESULTS: The peptide has the ability to interact with the NF-kappaB p50 subunit and can effectively inhibit TNF-alpha and IL-6 production in the THP-1 cell line, PMA-induced ear edema and zymosan A-induced peritonitis in mice.	Tetradecanoylphorbol Acetate	162-165	tumor necrosis factor	Homo sapiens	108-117
17049124-5	2006	RESULTS: The peptide has the ability to interact with the NF-kappaB p50 subunit and can effectively inhibit TNF-alpha and IL-6 production in the THP-1 cell line, PMA-induced ear edema and zymosan A-induced peritonitis in mice.	Tetradecanoylphorbol Acetate	162-165	interleukin 6	Homo sapiens	122-126
17013757-5	2006	Interestingly, the apoptotic events such as DNA ladders formation and activation of the caspase 3 cascade were significantly blocked by TPA addition in the presence of membrane translocation of PKCalpha, and TPA-induced protection was reduced by adding the PKC inhibitors, GF-109203X and staurosporin.	Tetradecanoylphorbol Acetate	136-139	caspase 3	Homo sapiens	88-97
17013757-5	2006	Interestingly, the apoptotic events such as DNA ladders formation and activation of the caspase 3 cascade were significantly blocked by TPA addition in the presence of membrane translocation of PKCalpha, and TPA-induced protection was reduced by adding the PKC inhibitors, GF-109203X and staurosporin.	Tetradecanoylphorbol Acetate	136-139	protein kinase C alpha	Homo sapiens	194-202
17013757-5	2006	Interestingly, the apoptotic events such as DNA ladders formation and activation of the caspase 3 cascade were significantly blocked by TPA addition in the presence of membrane translocation of PKCalpha, and TPA-induced protection was reduced by adding the PKC inhibitors, GF-109203X and staurosporin.	Tetradecanoylphorbol Acetate	136-139	protein kinase C alpha	Homo sapiens	194-197
17013757-5	2006	Interestingly, the apoptotic events such as DNA ladders formation and activation of the caspase 3 cascade were significantly blocked by TPA addition in the presence of membrane translocation of PKCalpha, and TPA-induced protection was reduced by adding the PKC inhibitors, GF-109203X and staurosporin.	Tetradecanoylphorbol Acetate	208-211	caspase 3	Homo sapiens	88-97
17013757-5	2006	Interestingly, the apoptotic events such as DNA ladders formation and activation of the caspase 3 cascade were significantly blocked by TPA addition in the presence of membrane translocation of PKCalpha, and TPA-induced protection was reduced by adding the PKC inhibitors, GF-109203X and staurosporin.	Tetradecanoylphorbol Acetate	208-211	protein kinase C alpha	Homo sapiens	194-202
17034361-2	2006	We investigated the effects of full-length human Ad (hAd) on phorbol 12-myristate 13-acetate (PMA)-induced O2-* generation by human neutrophils.	Tetradecanoylphorbol Acetate	61-92	adiponectin, C1Q and collagen domain containing	Homo sapiens	49-51
17034361-2	2006	We investigated the effects of full-length human Ad (hAd) on phorbol 12-myristate 13-acetate (PMA)-induced O2-* generation by human neutrophils.	Tetradecanoylphorbol Acetate	94-97	adiponectin, C1Q and collagen domain containing	Homo sapiens	49-51
17013757-5	2006	Interestingly, the apoptotic events such as DNA ladders formation and activation of the caspase 3 cascade were significantly blocked by TPA addition in the presence of membrane translocation of PKCalpha, and TPA-induced protection was reduced by adding the PKC inhibitors, GF-109203X and staurosporin.	Tetradecanoylphorbol Acetate	208-211	protein kinase C alpha	Homo sapiens	194-197
17013757-7	2006	In addition, PKC inhibitor GF-109203X treatment blocks TPA-induced ERKs and JNKs protein phosphorylation, which indicates that activation of PKC locates at upstream of MAPKs activation in TPA-treated HL-60 cells.	Tetradecanoylphorbol Acetate	55-58	protein kinase C alpha	Homo sapiens	141-144
17013757-6	2006	TPA addition induces the phosphorylation of JNKs and ERKs, but not p38, protein in HL-60 cells, and incubation of HL-60 cells with JNKs inhibitor SP600125, but not ERKs inhibitor, PD98059 or the p38 inhibitor SB203580, suppressed the protective effect of TPA against BE-induced apoptotic events including DNA ladders, apoptotic bodies, caspase 3 and D4-GDI protein cleavage in according with blocking JNKs protein phosphorylation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	195-198
17013757-6	2006	TPA addition induces the phosphorylation of JNKs and ERKs, but not p38, protein in HL-60 cells, and incubation of HL-60 cells with JNKs inhibitor SP600125, but not ERKs inhibitor, PD98059 or the p38 inhibitor SB203580, suppressed the protective effect of TPA against BE-induced apoptotic events including DNA ladders, apoptotic bodies, caspase 3 and D4-GDI protein cleavage in according with blocking JNKs protein phosphorylation.	Tetradecanoylphorbol Acetate	0-3	caspase 3	Homo sapiens	336-345
17013757-7	2006	In addition, PKC inhibitor GF-109203X treatment blocks TPA-induced ERKs and JNKs protein phosphorylation, which indicates that activation of PKC locates at upstream of MAPKs activation in TPA-treated HL-60 cells.	Tetradecanoylphorbol Acetate	188-191	protein kinase C alpha	Homo sapiens	13-16
17013757-7	2006	In addition, PKC inhibitor GF-109203X treatment blocks TPA-induced ERKs and JNKs protein phosphorylation, which indicates that activation of PKC locates at upstream of MAPKs activation in TPA-treated HL-60 cells.	Tetradecanoylphorbol Acetate	188-191	protein kinase C alpha	Homo sapiens	141-144
17013757-9	2006	GF-109203X and SP600125 suppression of TPA against cytochrome c release induced by BE was identified.	Tetradecanoylphorbol Acetate	39-42	cytochrome c, somatic	Homo sapiens	51-63
17013757-10	2006	This suggests that activation of PKC and JNKs participate in TPA"s prevention of BE-induced apoptosis via suppressing mitochondrial dysfunction in HL-60 cells.	Tetradecanoylphorbol Acetate	61-64	protein kinase C alpha	Homo sapiens	33-36
16632868-3	2006	Interleukin (IL) 1beta, tumor necrosis factor-alpha (TNF-alpha) or phorbol ester [phorbol 12-myristate 13-acetate (PMA)] induced the expression of COX-2, as revealed by western blot analysis.	Tetradecanoylphorbol Acetate	82-113	interleukin 1 beta	Homo sapiens	0-22
16632868-3	2006	Interleukin (IL) 1beta, tumor necrosis factor-alpha (TNF-alpha) or phorbol ester [phorbol 12-myristate 13-acetate (PMA)] induced the expression of COX-2, as revealed by western blot analysis.	Tetradecanoylphorbol Acetate	82-113	tumor necrosis factor	Homo sapiens	24-51
16632868-3	2006	Interleukin (IL) 1beta, tumor necrosis factor-alpha (TNF-alpha) or phorbol ester [phorbol 12-myristate 13-acetate (PMA)] induced the expression of COX-2, as revealed by western blot analysis.	Tetradecanoylphorbol Acetate	82-113	prostaglandin-endoperoxide synthase 2	Homo sapiens	147-152
16632868-3	2006	Interleukin (IL) 1beta, tumor necrosis factor-alpha (TNF-alpha) or phorbol ester [phorbol 12-myristate 13-acetate (PMA)] induced the expression of COX-2, as revealed by western blot analysis.	Tetradecanoylphorbol Acetate	115-118	interleukin 1 beta	Homo sapiens	0-22
16632868-3	2006	Interleukin (IL) 1beta, tumor necrosis factor-alpha (TNF-alpha) or phorbol ester [phorbol 12-myristate 13-acetate (PMA)] induced the expression of COX-2, as revealed by western blot analysis.	Tetradecanoylphorbol Acetate	115-118	tumor necrosis factor	Homo sapiens	24-51
16632868-3	2006	Interleukin (IL) 1beta, tumor necrosis factor-alpha (TNF-alpha) or phorbol ester [phorbol 12-myristate 13-acetate (PMA)] induced the expression of COX-2, as revealed by western blot analysis.	Tetradecanoylphorbol Acetate	115-118	tumor necrosis factor	Homo sapiens	53-62
16632868-3	2006	Interleukin (IL) 1beta, tumor necrosis factor-alpha (TNF-alpha) or phorbol ester [phorbol 12-myristate 13-acetate (PMA)] induced the expression of COX-2, as revealed by western blot analysis.	Tetradecanoylphorbol Acetate	115-118	prostaglandin-endoperoxide synthase 2	Homo sapiens	147-152
17067317-6	2006	These cellular responses were also observed when the THP-1 cells were treated with phorbol-12 myristate-13 acetate (PMA), which is known to induce macrophage differentiation.	Tetradecanoylphorbol Acetate	83-114	GLI family zinc finger 2	Homo sapiens	53-58
17072500-4	2006	The treatment of tumor cells with two NF-kappaB inducers, tumor necrosis factor-alpha and phorbol 12-myristate 13-acetate, decreased HLA-G1 cell surface expression but increased intracytoplasmic HLA-G proteins.	Tetradecanoylphorbol Acetate	90-121	nuclear factor kappa B subunit 1	Homo sapiens	38-47
16987710-1	2006	CD4+ and CD8+ lymphocyte cytokine production in patients with HIV/AIDS and Controls, in response to stimulation with phorbol-12-myristate-13-acetate (PMA) and ionomycin was assessed using single cell flow cytometric methods.	Tetradecanoylphorbol Acetate	117-148	CD4 molecule	Homo sapiens	0-3
16987710-1	2006	CD4+ and CD8+ lymphocyte cytokine production in patients with HIV/AIDS and Controls, in response to stimulation with phorbol-12-myristate-13-acetate (PMA) and ionomycin was assessed using single cell flow cytometric methods.	Tetradecanoylphorbol Acetate	150-153	CD4 molecule	Homo sapiens	0-3
16916948-9	2006	The desensitizing effect of CDCA was bile acid-specific and was significantly reduced in the presence of PKC inhibitors and after PKC down-regulation by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	153-184	protein kinase C alpha	Homo sapiens	130-133
17067317-6	2006	These cellular responses were also observed when the THP-1 cells were treated with phorbol-12 myristate-13 acetate (PMA), which is known to induce macrophage differentiation.	Tetradecanoylphorbol Acetate	116-119	GLI family zinc finger 2	Homo sapiens	53-58
17007743-9	2006	After treatment with PKC activator, phorbol 12-myristate 13-acetate (PMA), cPKC translocated to the periphery of oocyte, and cortical granules (CG) exocytosis was found.	Tetradecanoylphorbol Acetate	36-67	proline rich transmembrane protein 2	Homo sapiens	21-24
17080406-7	2006	Furthermore, the activation of ERK1/2 by ACN was attenuated by inhibition of PKC with GF 109203X, rottlerin and prolonged incubation with PMA (phorbol 12-myristate 13-acetate).	Tetradecanoylphorbol Acetate	138-141	mitogen-activated protein kinase 3	Homo sapiens	31-37
17080406-7	2006	Furthermore, the activation of ERK1/2 by ACN was attenuated by inhibition of PKC with GF 109203X, rottlerin and prolonged incubation with PMA (phorbol 12-myristate 13-acetate).	Tetradecanoylphorbol Acetate	143-174	mitogen-activated protein kinase 3	Homo sapiens	31-37
16890260-8	2006	Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-8 and IL-6 secretion in human mast cells.	Tetradecanoylphorbol Acetate	33-64	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
16890260-8	2006	Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-8 and IL-6 secretion in human mast cells.	Tetradecanoylphorbol Acetate	33-64	interleukin 6	Homo sapiens	131-135
16945329-2	2006	In the current study, we investigated the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of PPARgamma and proliferation of A549 cells.	Tetradecanoylphorbol Acetate	52-88	peroxisome proliferator activated receptor gamma	Homo sapiens	116-125
16945329-2	2006	In the current study, we investigated the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of PPARgamma and proliferation of A549 cells.	Tetradecanoylphorbol Acetate	90-93	peroxisome proliferator activated receptor gamma	Homo sapiens	116-125
16475165-0	2006	Knockdown of NFAT3 blocked TPA-induced COX-2 and iNOS expression, and enhanced cell transformation in Cl41 cells.	Tetradecanoylphorbol Acetate	27-30	nitric oxide synthase 2, inducible	Mus musculus	49-53
16475165-8	2006	At the same time, TPA-induced expression of both COX-2 and inducible nitric oxide synthase (iNOS) were blocked.	Tetradecanoylphorbol Acetate	18-21	nitric oxide synthase 2, inducible	Mus musculus	59-90
16475165-8	2006	At the same time, TPA-induced expression of both COX-2 and inducible nitric oxide synthase (iNOS) were blocked.	Tetradecanoylphorbol Acetate	18-21	nitric oxide synthase 2, inducible	Mus musculus	92-96
16475165-10	2006	Moreover, treatment with the iNOS specific inhibitor aminoguanidine (AG) also enhanced Cl41 cells transformation induced by TPA.	Tetradecanoylphorbol Acetate	124-127	nitric oxide synthase 2, inducible	Mus musculus	29-33
16945329-3	2006	TPA elicited a dose- and time-dependent increase in PPARgamma mRNA and protein levels.	Tetradecanoylphorbol Acetate	0-3	peroxisome proliferator activated receptor gamma	Homo sapiens	52-61
16945329-4	2006	PPARgamma expression in response to TPA was attenuated by pretreatment with bisindolylmaleimide I, N-acetyl-L-cysteine (NAC) and PD98059.	Tetradecanoylphorbol Acetate	36-39	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
16945329-5	2006	TPA-induced protein kinase C (PKC) activation was linked to the generation of reactive oxygen species (ROS), both of which were indispensable for PPARgamma expression in A549 cells.	Tetradecanoylphorbol Acetate	0-3	peroxisome proliferator activated receptor gamma	Homo sapiens	146-155
16945329-6	2006	Pretreatment with bisindolylmaleimide I or NAC blocked TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK), suggesting that ERK-mediated signaling is also involved in the induction of PPARgamma.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 1	Homo sapiens	86-123
16945329-6	2006	Pretreatment with bisindolylmaleimide I or NAC blocked TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK), suggesting that ERK-mediated signaling is also involved in the induction of PPARgamma.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 1	Homo sapiens	125-128
16945329-6	2006	Pretreatment with bisindolylmaleimide I or NAC blocked TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK), suggesting that ERK-mediated signaling is also involved in the induction of PPARgamma.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 1	Homo sapiens	147-150
16945329-6	2006	Pretreatment with bisindolylmaleimide I or NAC blocked TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK), suggesting that ERK-mediated signaling is also involved in the induction of PPARgamma.	Tetradecanoylphorbol Acetate	55-58	peroxisome proliferator activated receptor gamma	Homo sapiens	207-216
16945329-9	2006	Taken together, these observations indicate that TPA synergizes with PPARgamma ligand to inhibit cell growth through up-regulation of PPARgamma expression.	Tetradecanoylphorbol Acetate	49-52	peroxisome proliferator activated receptor gamma	Homo sapiens	134-143
17047069-6	2006	In HT-29 colon cancer cells, carcinogenic agent 12-O-tetradecanoylphorbol-13-acetate (TPA) activated extracellular signal-regulated kinase (ERK) that led to COX-2 expression and selenium blocked the TPA-induced ERK and COX-2 activation via AMPK.	Tetradecanoylphorbol Acetate	48-84	mitogen-activated protein kinase 1	Homo sapiens	101-138
17047069-6	2006	In HT-29 colon cancer cells, carcinogenic agent 12-O-tetradecanoylphorbol-13-acetate (TPA) activated extracellular signal-regulated kinase (ERK) that led to COX-2 expression and selenium blocked the TPA-induced ERK and COX-2 activation via AMPK.	Tetradecanoylphorbol Acetate	48-84	mitogen-activated protein kinase 1	Homo sapiens	140-143
17047069-6	2006	In HT-29 colon cancer cells, carcinogenic agent 12-O-tetradecanoylphorbol-13-acetate (TPA) activated extracellular signal-regulated kinase (ERK) that led to COX-2 expression and selenium blocked the TPA-induced ERK and COX-2 activation via AMPK.	Tetradecanoylphorbol Acetate	48-84	prostaglandin-endoperoxide synthase 2	Homo sapiens	157-162
17047069-6	2006	In HT-29 colon cancer cells, carcinogenic agent 12-O-tetradecanoylphorbol-13-acetate (TPA) activated extracellular signal-regulated kinase (ERK) that led to COX-2 expression and selenium blocked the TPA-induced ERK and COX-2 activation via AMPK.	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase 1	Homo sapiens	101-138
17047069-6	2006	In HT-29 colon cancer cells, carcinogenic agent 12-O-tetradecanoylphorbol-13-acetate (TPA) activated extracellular signal-regulated kinase (ERK) that led to COX-2 expression and selenium blocked the TPA-induced ERK and COX-2 activation via AMPK.	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase 1	Homo sapiens	140-143
17047069-6	2006	In HT-29 colon cancer cells, carcinogenic agent 12-O-tetradecanoylphorbol-13-acetate (TPA) activated extracellular signal-regulated kinase (ERK) that led to COX-2 expression and selenium blocked the TPA-induced ERK and COX-2 activation via AMPK.	Tetradecanoylphorbol Acetate	86-89	prostaglandin-endoperoxide synthase 2	Homo sapiens	157-162
17047069-6	2006	In HT-29 colon cancer cells, carcinogenic agent 12-O-tetradecanoylphorbol-13-acetate (TPA) activated extracellular signal-regulated kinase (ERK) that led to COX-2 expression and selenium blocked the TPA-induced ERK and COX-2 activation via AMPK.	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase 1	Homo sapiens	211-214
17047069-6	2006	In HT-29 colon cancer cells, carcinogenic agent 12-O-tetradecanoylphorbol-13-acetate (TPA) activated extracellular signal-regulated kinase (ERK) that led to COX-2 expression and selenium blocked the TPA-induced ERK and COX-2 activation via AMPK.	Tetradecanoylphorbol Acetate	86-89	prostaglandin-endoperoxide synthase 2	Homo sapiens	219-224
17047069-6	2006	In HT-29 colon cancer cells, carcinogenic agent 12-O-tetradecanoylphorbol-13-acetate (TPA) activated extracellular signal-regulated kinase (ERK) that led to COX-2 expression and selenium blocked the TPA-induced ERK and COX-2 activation via AMPK.	Tetradecanoylphorbol Acetate	199-202	mitogen-activated protein kinase 1	Homo sapiens	140-143
16890195-7	2006	The AIRE promoter activity could be stimulated by phorbol myristate acetate (PMA) and this activation was further enhanced by Ets transcription factors.	Tetradecanoylphorbol Acetate	50-75	autoimmune regulator	Homo sapiens	4-8
17015253-2	2006	Previously, we described that ( - )-epicatechin (EC) inhibits PMA-induced NF-kappaB activation in Jurkat T cells.	Tetradecanoylphorbol Acetate	62-65	nuclear factor kappa B subunit 1	Homo sapiens	74-83
16890208-7	2006	RLIP76-/- MEFs were resistant to PKCalpha-depletion mediated growth inhibition, as well as to the PKCalpha-dependent mitogen, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	126-157	protein kinase C alpha	Homo sapiens	98-106
16964312-1	2006	Transgenic mice overexpressing PKCalpha in the epidermis (K5-PKCalpha mice) exhibit an inducible severe intraepidermal neutrophilic inflammation and systemic neutrophilia when PKCalpha is activated by topical 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	209-245	protein kinase C, alpha	Mus musculus	31-39
16964312-1	2006	Transgenic mice overexpressing PKCalpha in the epidermis (K5-PKCalpha mice) exhibit an inducible severe intraepidermal neutrophilic inflammation and systemic neutrophilia when PKCalpha is activated by topical 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	247-250	protein kinase C, alpha	Mus musculus	31-39
16964312-4	2006	TPA treatment of cultured K5-PKCalpha keratinocytes also released KC and MIP-2 into culture supernatants through an NF-kappaB-dependent pathway.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Mus musculus	29-37
16964312-4	2006	TPA treatment of cultured K5-PKCalpha keratinocytes also released KC and MIP-2 into culture supernatants through an NF-kappaB-dependent pathway.	Tetradecanoylphorbol Acetate	0-3	chemokine (C-X-C motif) ligand 2	Mus musculus	73-78
16964312-8	2006	Inhibiting PKCalpha also reduced the basal and TNF-alpha- or TPA-induced expression of CXCL8 in cultured psoriatic keratinocytes, suggesting that PKCalpha activity may contribute to psoriatic inflammation.	Tetradecanoylphorbol Acetate	61-64	protein kinase C, alpha	Mus musculus	11-19
16964312-8	2006	Inhibiting PKCalpha also reduced the basal and TNF-alpha- or TPA-induced expression of CXCL8 in cultured psoriatic keratinocytes, suggesting that PKCalpha activity may contribute to psoriatic inflammation.	Tetradecanoylphorbol Acetate	61-64	protein kinase C, alpha	Mus musculus	146-154
16574371-4	2006	FPT dose dependently decreased the gene expression and production of TNF-alpha and IL-6 on phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	91-122	tumor necrosis factor	Homo sapiens	69-78
16574371-4	2006	FPT dose dependently decreased the gene expression and production of TNF-alpha and IL-6 on phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	91-122	interleukin 6	Homo sapiens	83-87
16574371-4	2006	FPT dose dependently decreased the gene expression and production of TNF-alpha and IL-6 on phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	124-127	tumor necrosis factor	Homo sapiens	69-78
16574371-4	2006	FPT dose dependently decreased the gene expression and production of TNF-alpha and IL-6 on phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	124-127	interleukin 6	Homo sapiens	83-87
16899228-1	2006	Protein kinase C (PKC) agonists including phorbol 12-myristate 13-acetate (PMA) not only induce the redistribution of cytosolic PKC to various subcellular compartments but also activate the kinase domain of the protein.	Tetradecanoylphorbol Acetate	42-73	protein kinase C, alpha	Mus musculus	18-21
16899228-1	2006	Protein kinase C (PKC) agonists including phorbol 12-myristate 13-acetate (PMA) not only induce the redistribution of cytosolic PKC to various subcellular compartments but also activate the kinase domain of the protein.	Tetradecanoylphorbol Acetate	42-73	protein kinase C, alpha	Mus musculus	128-131
16899228-1	2006	Protein kinase C (PKC) agonists including phorbol 12-myristate 13-acetate (PMA) not only induce the redistribution of cytosolic PKC to various subcellular compartments but also activate the kinase domain of the protein.	Tetradecanoylphorbol Acetate	75-78	protein kinase C, alpha	Mus musculus	18-21
16899228-1	2006	Protein kinase C (PKC) agonists including phorbol 12-myristate 13-acetate (PMA) not only induce the redistribution of cytosolic PKC to various subcellular compartments but also activate the kinase domain of the protein.	Tetradecanoylphorbol Acetate	75-78	protein kinase C, alpha	Mus musculus	128-131
16899228-3	2006	Treatment of C2C12 myoblasts, C6 glioma and COS7 cells with PMA resulted in a dramatic redistribution of intracellular PKCalpha pool, with large fraction of the protein pool sequestered in the mitochondrial compartment.	Tetradecanoylphorbol Acetate	60-63	protein kinase C, alpha	Mus musculus	119-127
16899228-6	2006	PMA-induced mitochondrial localization of PKCalpha was accompanied by increased mitochondrial PKC activity, altered cell morphology, disruption of mitochondrial membrane potential, decreased complex I and pyruvate dehydrogenase activities, and increased mitochondrial ROS production.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Mus musculus	42-50
16899228-6	2006	PMA-induced mitochondrial localization of PKCalpha was accompanied by increased mitochondrial PKC activity, altered cell morphology, disruption of mitochondrial membrane potential, decreased complex I and pyruvate dehydrogenase activities, and increased mitochondrial ROS production.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Mus musculus	42-45
16899228-8	2006	These results show a direct role for PMA-mediated PKCalpha translocation to mitochondria in inducing mitochondrial toxicity.	Tetradecanoylphorbol Acetate	37-40	protein kinase C, alpha	Mus musculus	50-58
16890195-7	2006	The AIRE promoter activity could be stimulated by phorbol myristate acetate (PMA) and this activation was further enhanced by Ets transcription factors.	Tetradecanoylphorbol Acetate	77-80	autoimmune regulator	Homo sapiens	4-8
16890203-4	2006	The expressions of the inflammatory cytokines, IL-1alpha and IL-1beta, were reduced in the TPA-treated Tg EC-SOD compared with those in TPA-treated WT.	Tetradecanoylphorbol Acetate	91-94	interleukin 1 beta	Mus musculus	61-69
16890203-4	2006	The expressions of the inflammatory cytokines, IL-1alpha and IL-1beta, were reduced in the TPA-treated Tg EC-SOD compared with those in TPA-treated WT.	Tetradecanoylphorbol Acetate	136-139	interleukin 1 beta	Mus musculus	61-69
16890203-6	2006	The number of infiltrating inflammatory cells and the IL-1beta expressing cells was obviously reduced in TPA-treated Tg EC-SOD in comparison with TPA-treated WT.	Tetradecanoylphorbol Acetate	105-108	interleukin 1 beta	Mus musculus	54-62
16890203-7	2006	The result suggests that EC-SOD might play an important role in the suppression of TPA-induced cutaneous inflammation and epidermal hyperplasia by regulating the expression of IL-1alpha and IL-1beta, although the mechanisms remain to be elucidated.	Tetradecanoylphorbol Acetate	83-86	interleukin 1 beta	Mus musculus	190-198
16846840-8	2006	Exposure to gp120 also stimulated the release of TNF-alpha from TPA-differentiated HL-60 cells.	Tetradecanoylphorbol Acetate	64-67	tumor necrosis factor	Homo sapiens	49-58
16979556-6	2006	Phorbol myristate acetate (PMA) activated alphaIIbbeta3 only after the increased expression of both recombinant protein kinase Calpha (PKCalpha) and talin to levels approximating those in platelets.	Tetradecanoylphorbol Acetate	0-25	protein kinase C alpha	Homo sapiens	135-143
16979556-6	2006	Phorbol myristate acetate (PMA) activated alphaIIbbeta3 only after the increased expression of both recombinant protein kinase Calpha (PKCalpha) and talin to levels approximating those in platelets.	Tetradecanoylphorbol Acetate	27-30	protein kinase C alpha	Homo sapiens	135-143
16870152-6	2006	The phorbol myristate acetate stimulated the PLD activities of pCDNA3.1-PLD-treated neutrophils but did not stimulate the activities of untreated or pCDNA3.1-treated neutrophils.	Tetradecanoylphorbol Acetate	4-29	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	45-48
16870152-6	2006	The phorbol myristate acetate stimulated the PLD activities of pCDNA3.1-PLD-treated neutrophils but did not stimulate the activities of untreated or pCDNA3.1-treated neutrophils.	Tetradecanoylphorbol Acetate	4-29	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	72-75
16313911-2	2006	Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) treatment, and can then be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL).	Tetradecanoylphorbol Acetate	80-105	GLI family zinc finger 2	Homo sapiens	6-11
16313911-2	2006	Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) treatment, and can then be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL).	Tetradecanoylphorbol Acetate	107-110	GLI family zinc finger 2	Homo sapiens	6-11
16846837-8	2006	These results suggest that Tau-Cl inhibits PMA-elicited O(2)(-) production in PLB-985 granulocytes by inhibiting phosphorylation of p47(phox) and translocation of p47(phox) and p67(phox), eventually blocking the assembly of NADPH oxidase complex.	Tetradecanoylphorbol Acetate	43-46	CD33 molecule	Homo sapiens	177-180
16846837-6	2006	Translocation of p47(phox), p67(phox) and Rac was increased in response to PMA, and Tau-Cl inhibited the PMA-stimulated translocation of p47(phox) and p67(phox) to plasma membrane without affecting the translocation of Rac.	Tetradecanoylphorbol Acetate	75-78	AKT serine/threonine kinase 1	Homo sapiens	28-45
16846837-6	2006	Translocation of p47(phox), p67(phox) and Rac was increased in response to PMA, and Tau-Cl inhibited the PMA-stimulated translocation of p47(phox) and p67(phox) to plasma membrane without affecting the translocation of Rac.	Tetradecanoylphorbol Acetate	75-78	CD33 molecule	Homo sapiens	28-31
16835219-3	2006	In contrast to other cellular sialidases Neu2, Neu3, and Neu4, whose expression either remains unchanged or is down-regulated, Neu1 mRNA, protein and activity are specifically increased during the phorbol 12-myristate 13-acetate-induced differentiation, consistent with a significant induction of the transcriptional activity of the Neu1 gene promoter.	Tetradecanoylphorbol Acetate	197-228	neuraminidase 4	Homo sapiens	57-61
16780501-3	2006	METHODS: Using peripheral blood mononuclear cells derived from individuals with severe (n=12) and mild atopic dermatitis (n=10) and from nonatopic controls (n=10), we investigated production by CD4+ T cells of tumour necrosis factor (TNF)-alpha, IL-4, IL-5, IL-13 and IL-10 in response to phorbol myristate acetate/ionomycin and Der p1 allergen.	Tetradecanoylphorbol Acetate	289-314	tumor necrosis factor	Homo sapiens	210-244
16846840-10	2006	Our data suggest that one of the mechanisms by which HIV-1 gp120 up-regulates the MOR in TPA-differentiated HL-60 cells is through autocrine/paracrine actions of TNF-alpha via the TNFR-II receptor.	Tetradecanoylphorbol Acetate	89-92	tumor necrosis factor	Homo sapiens	162-171
16637058-3	2006	Panc-1 cells transfected with CCK1 receptors were treated with cholecystokinin (CCK), neurotensin (NT), or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	107-138	C-C motif chemokine ligand 28	Homo sapiens	30-34
16912315-8	2006	First, ectopic M2L expression hampered ERK2 phosphorylation induced by exposure to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	83-108	mitogen-activated protein kinase 1	Homo sapiens	39-43
16738222-3	2006	We found that T3 reverses the activation of the SOD-1 promoter caused by the free radical generators paraquat and phorbol 12-myristate 13-acetate through the direct repression of the SOD-1 promoter by liganded TR.	Tetradecanoylphorbol Acetate	114-145	superoxide dismutase 1	Homo sapiens	48-53
16738222-3	2006	We found that T3 reverses the activation of the SOD-1 promoter caused by the free radical generators paraquat and phorbol 12-myristate 13-acetate through the direct repression of the SOD-1 promoter by liganded TR.	Tetradecanoylphorbol Acetate	114-145	superoxide dismutase 1	Homo sapiens	183-188
16982432-2	2006	METHODS: Monocytic THP-1 cells were cultured in the presence of 100 nmol/L phorbol myristate acetate (PMA) for 72 h to transform the cells into THP-1 macrophages.	Tetradecanoylphorbol Acetate	75-100	GLI family zinc finger 2	Homo sapiens	19-24
16982432-2	2006	METHODS: Monocytic THP-1 cells were cultured in the presence of 100 nmol/L phorbol myristate acetate (PMA) for 72 h to transform the cells into THP-1 macrophages.	Tetradecanoylphorbol Acetate	75-100	GLI family zinc finger 2	Homo sapiens	144-149
16982432-2	2006	METHODS: Monocytic THP-1 cells were cultured in the presence of 100 nmol/L phorbol myristate acetate (PMA) for 72 h to transform the cells into THP-1 macrophages.	Tetradecanoylphorbol Acetate	102-105	GLI family zinc finger 2	Homo sapiens	19-24
16982432-2	2006	METHODS: Monocytic THP-1 cells were cultured in the presence of 100 nmol/L phorbol myristate acetate (PMA) for 72 h to transform the cells into THP-1 macrophages.	Tetradecanoylphorbol Acetate	102-105	GLI family zinc finger 2	Homo sapiens	144-149
16680484-10	2006	Phorbol myristate acetate (PKC activator) mimicked in part the stimulatory effect of ANG II, but reduced Ca(+2) (i).	Tetradecanoylphorbol Acetate	0-25	angiotensinogen	Rattus norvegicus	85-91
16912211-3	2006	7,12-Dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate treatments resulted in an increase in the incidence of skin tumors and tumor numbers per mouse in both genotypes; however, both indices were markedly higher in Nrf2(-/-) mice as compared with Nrf2(+/+) mice.	Tetradecanoylphorbol Acetate	31-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	228-232
16912211-3	2006	7,12-Dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate treatments resulted in an increase in the incidence of skin tumors and tumor numbers per mouse in both genotypes; however, both indices were markedly higher in Nrf2(-/-) mice as compared with Nrf2(+/+) mice.	Tetradecanoylphorbol Acetate	31-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	260-264
16846837-6	2006	Translocation of p47(phox), p67(phox) and Rac was increased in response to PMA, and Tau-Cl inhibited the PMA-stimulated translocation of p47(phox) and p67(phox) to plasma membrane without affecting the translocation of Rac.	Tetradecanoylphorbol Acetate	75-78	AKT serine/threonine kinase 1	Homo sapiens	42-45
16787983-4	2006	DESIGN: Human monocytic THP1-cells were differentiated and activated by IFNgamma and a secondary stimulus, such as lipopolysaccharide or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	137-162	GLI family zinc finger 2	Homo sapiens	24-28
16787983-8	2006	In contrast, in phorbol myristate acetate-differentiated THP1 macrophages, IFNgamma alone induces 1alpha-hydroxylase and to much higher levels.	Tetradecanoylphorbol Acetate	16-41	GLI family zinc finger 2	Homo sapiens	57-61
16787983-8	2006	In contrast, in phorbol myristate acetate-differentiated THP1 macrophages, IFNgamma alone induces 1alpha-hydroxylase and to much higher levels.	Tetradecanoylphorbol Acetate	16-41	interferon gamma	Homo sapiens	75-83
16798936-0	2006	Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: Implication for the regulatory role of protein kinase C. Protein kinase C (PKC) triggers cellular signals that regulate proliferation or death in a cell- and stimulus-specific manner.	Tetradecanoylphorbol Acetate	0-31	tumor necrosis factor	Mus musculus	49-70
16798936-0	2006	Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: Implication for the regulatory role of protein kinase C. Protein kinase C (PKC) triggers cellular signals that regulate proliferation or death in a cell- and stimulus-specific manner.	Tetradecanoylphorbol Acetate	0-31	tumor necrosis factor	Mus musculus	72-75
16798936-0	2006	Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: Implication for the regulatory role of protein kinase C. Protein kinase C (PKC) triggers cellular signals that regulate proliferation or death in a cell- and stimulus-specific manner.	Tetradecanoylphorbol Acetate	0-31	tumor necrosis factor	Mus musculus	138-141
16798936-0	2006	Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: Implication for the regulatory role of protein kinase C. Protein kinase C (PKC) triggers cellular signals that regulate proliferation or death in a cell- and stimulus-specific manner.	Tetradecanoylphorbol Acetate	0-31	tumor necrosis factor	Mus musculus	138-141
16798936-2	2006	Here, we demonstrate that PMA-mediated activation of PKC protects against tumor necrosis factor (TNF)-induced necrosis by disrupting formation of the TNF receptor (TNFR)1 signaling complex.	Tetradecanoylphorbol Acetate	26-29	tumor necrosis factor	Mus musculus	74-95
16798936-2	2006	Here, we demonstrate that PMA-mediated activation of PKC protects against tumor necrosis factor (TNF)-induced necrosis by disrupting formation of the TNF receptor (TNFR)1 signaling complex.	Tetradecanoylphorbol Acetate	26-29	tumor necrosis factor	Mus musculus	97-100
16798936-2	2006	Here, we demonstrate that PMA-mediated activation of PKC protects against tumor necrosis factor (TNF)-induced necrosis by disrupting formation of the TNF receptor (TNFR)1 signaling complex.	Tetradecanoylphorbol Acetate	26-29	tumor necrosis factor	Mus musculus	150-153
16798936-3	2006	Pretreatment with PMA protected L929 cells from TNF-induced necrotic cell death in a PKC-dependent manner, but it did not protect against DNA-damaging agents, including doxorubicin (Adriamycin) and camptothecin.	Tetradecanoylphorbol Acetate	18-21	tumor necrosis factor	Mus musculus	48-51
16966442-7	2006	Levels of COX-2 protein in CMT12 decreased in a time-dependent manner with serum starvation, and PMA stimulation induced a strong time-dependent increase in COX-2 protein.	Tetradecanoylphorbol Acetate	97-100	prostaglandin-endoperoxide synthase 2	Homo sapiens	157-162
16637058-3	2006	Panc-1 cells transfected with CCK1 receptors were treated with cholecystokinin (CCK), neurotensin (NT), or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	140-143	C-C motif chemokine ligand 28	Homo sapiens	30-34
16710050-8	2006	CDCA at concentrations less than 50 microM enhanced the PKCalpha activation induced by PMA, whereas greater CDCA concentrations reduced the PMA-induced PKCalpha activation.	Tetradecanoylphorbol Acetate	87-90	protein kinase C alpha	Homo sapiens	56-64
16814765-3	2006	Provided eosinophils were incubated for &lt;20 min at 37 degrees C before stimulation, PMA potently stimulated cAMP generation that surpassed that of histamine.	Tetradecanoylphorbol Acetate	87-90	cathelicidin antimicrobial peptide	Homo sapiens	111-115
16814765-4	2006	Pre-treatment of the cells with the NADPH oxidase inhibitors, diphenyleneiodonium (DPI) and apocynin, strongly inhibited the cAMP production induced by PMA, but not that induced by histamine.	Tetradecanoylphorbol Acetate	152-155	cathelicidin antimicrobial peptide	Homo sapiens	125-129
16814765-1	2006	Recently, we showed that phorbol 12-myristate 13-acetate (PMA) can cause a direct, PKC-dependent, stimulation of intracellular cAMP in human eosinophils.	Tetradecanoylphorbol Acetate	25-56	cathelicidin antimicrobial peptide	Homo sapiens	127-131
16814765-1	2006	Recently, we showed that phorbol 12-myristate 13-acetate (PMA) can cause a direct, PKC-dependent, stimulation of intracellular cAMP in human eosinophils.	Tetradecanoylphorbol Acetate	58-61	cathelicidin antimicrobial peptide	Homo sapiens	127-131
16740634-10	2006	Using ChIP assays and immunoprecipitation, we further demonstrated that p53 interacts with Sp1 to suppress both the constitutive and 12-O-tetradecanoylphorbol-13-acetate-stimulated expression of the MnSOD gene.	Tetradecanoylphorbol Acetate	133-169	tumor protein p53	Homo sapiens	72-75
16574993-8	2006	PMA-induced transcellular ISC correlated with PKC-alpha membrane association, whereas low doses of both agents inhibited transcellular and apical membrane ISC-cAMP, increased PKC-beta1, decreased PKC-beta2 membrane association, and caused reciprocal changes in isoform mass.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	46-55
16843450-3	2006	METHODS AND RESULTS: Acute exposure of a mouse macrophage cell line (RAW 264.7) to both PMA and oxLDL provoked ROS generation that was blocked by the PKCalpha/beta1 inhibitor Go 6967.	Tetradecanoylphorbol Acetate	88-91	protein kinase C, alpha	Mus musculus	150-158
16761109-1	2006	The antiapoptotic BCL2 family member MCL1 is rapidly upregulated upon exposure of ML-1 myeloid leukemia cells to either differentiation-inducing phorbol 12"-myristate 13"-acetate (PMA) or chemotherapeutic microtubule disrupting agents (MTDAs).	Tetradecanoylphorbol Acetate	145-178	BCL2 apoptosis regulator	Homo sapiens	18-22
16761109-1	2006	The antiapoptotic BCL2 family member MCL1 is rapidly upregulated upon exposure of ML-1 myeloid leukemia cells to either differentiation-inducing phorbol 12"-myristate 13"-acetate (PMA) or chemotherapeutic microtubule disrupting agents (MTDAs).	Tetradecanoylphorbol Acetate	180-183	BCL2 apoptosis regulator	Homo sapiens	18-22
16814409-7	2006	In MCF7 cells, where the ERK pathway is inactivated and MMPs are not secreted and the ERK pathway can be activated by PMA, the PMA-induced ERK phosphorylation was reduced by the expression of rpS3.	Tetradecanoylphorbol Acetate	118-121	mitogen-activated protein kinase 1	Homo sapiens	86-89
16814409-7	2006	In MCF7 cells, where the ERK pathway is inactivated and MMPs are not secreted and the ERK pathway can be activated by PMA, the PMA-induced ERK phosphorylation was reduced by the expression of rpS3.	Tetradecanoylphorbol Acetate	118-121	mitogen-activated protein kinase 1	Homo sapiens	86-89
16843450-6	2006	PMA, a well-established PKCalpha activator, inhibited ROS formation as well when preincubated for 8 to 16 h. In cells stably overexpressing PKCalpha-EGFP, we noticed that ROS formation remained intact upon pre-exposure of these cells to oxLDL.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Mus musculus	24-32
16872362-5	2006	Using synchronized HeLa cells, we show that activation of the extracellular signal-regulated kinase pathway with phorbol 12-myristate 13-acetate or epidermal growth factor during G(2) phase causes a rapid cell cycle arrest in G(2) as measured by flow cytometry, mitotic indices and cyclin B1 expression.	Tetradecanoylphorbol Acetate	113-144	mitogen-activated protein kinase 1	Homo sapiens	62-99
16843450-6	2006	PMA, a well-established PKCalpha activator, inhibited ROS formation as well when preincubated for 8 to 16 h. In cells stably overexpressing PKCalpha-EGFP, we noticed that ROS formation remained intact upon pre-exposure of these cells to oxLDL.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Mus musculus	140-148
16574739-7	2006	By comparing the pharmacological characteristics of phorbol 12-myristate 13-acetate-stimulated Ser24 phosphorylation with phosphorylation at two other sites previously linked to PKC activity (Ser307 and Ser612), we show that PKCalpha is likely to be directly involved in Ser24 phosphorylation, but indirectly involved in Ser307 and Ser612 phosphorylation.	Tetradecanoylphorbol Acetate	52-83	proline rich transmembrane protein 2	Homo sapiens	178-181
16893987-9	2006	Pretreatment of the cells with phorbol myristate acetate to enhance ERK activation reduced p40 production in response to the optimal LPS stimulation.	Tetradecanoylphorbol Acetate	31-56	mitogen-activated protein kinase 1	Mus musculus	68-71
16762451-6	2006	HT-29/DCC cells show no changes in adherent junctions but upon treatment with TPA, HT-29/DCC cells show resistance to scattering, and maintain E-cadherin in the membrane.	Tetradecanoylphorbol Acetate	78-81	cadherin 1	Homo sapiens	143-153
16574739-7	2006	By comparing the pharmacological characteristics of phorbol 12-myristate 13-acetate-stimulated Ser24 phosphorylation with phosphorylation at two other sites previously linked to PKC activity (Ser307 and Ser612), we show that PKCalpha is likely to be directly involved in Ser24 phosphorylation, but indirectly involved in Ser307 and Ser612 phosphorylation.	Tetradecanoylphorbol Acetate	52-83	protein kinase C alpha	Homo sapiens	225-233
16169661-0	2006	Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	78-81	protein kinase C alpha	Homo sapiens	0-22
16928326-1	2006	This study was aimed to investigate whether hydroquinone (HQ) can inhibit NF-kappaB expression activated by phorbol myristate acetate (PMA), and to explore the relationship between the mechanism and the hematology toxicity of benzene tentatively.	Tetradecanoylphorbol Acetate	108-133	nuclear factor kappa B subunit 1	Homo sapiens	74-83
16928326-1	2006	This study was aimed to investigate whether hydroquinone (HQ) can inhibit NF-kappaB expression activated by phorbol myristate acetate (PMA), and to explore the relationship between the mechanism and the hematology toxicity of benzene tentatively.	Tetradecanoylphorbol Acetate	135-138	nuclear factor kappa B subunit 1	Homo sapiens	74-83
16889690-4	2006	Genistein significantly inhibited 12-Otetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 activity and protein expression at the concentrations of 10 (p &lt; 0.05), 25 (p &lt; 0.05) and 50 mM (p &lt; 0.01).	Tetradecanoylphorbol Acetate	34-69	prostaglandin-endoperoxide synthase 2	Homo sapiens	84-100
16889690-4	2006	Genistein significantly inhibited 12-Otetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 activity and protein expression at the concentrations of 10 (p &lt; 0.05), 25 (p &lt; 0.05) and 50 mM (p &lt; 0.01).	Tetradecanoylphorbol Acetate	71-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	84-100
16868480-8	2006	The TPA decreased cyclin A and B expression, increased cyclin E, and markedly increased the expression of p21 at both the messenger RNA and protein levels.	Tetradecanoylphorbol Acetate	4-7	cyclin A2	Homo sapiens	18-32
16868480-8	2006	The TPA decreased cyclin A and B expression, increased cyclin E, and markedly increased the expression of p21 at both the messenger RNA and protein levels.	Tetradecanoylphorbol Acetate	4-7	cyclin dependent kinase inhibitor 1A	Homo sapiens	106-109
16868480-9	2006	TPA-induced p21 expression and growth inhibition were blocked by the PKC inhibitor, bisindoylmaleimide.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	12-15
16868480-10	2006	TPA induced extracellular signal-regulated kinase1/2 phosphorylation, whereas the MEK inhibitor, PD98059, blocked the TPA-induced p21 expression.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	12-52
16868480-10	2006	TPA induced extracellular signal-regulated kinase1/2 phosphorylation, whereas the MEK inhibitor, PD98059, blocked the TPA-induced p21 expression.	Tetradecanoylphorbol Acetate	118-121	mitogen-activated protein kinase kinase 7	Homo sapiens	82-85
16868480-10	2006	TPA induced extracellular signal-regulated kinase1/2 phosphorylation, whereas the MEK inhibitor, PD98059, blocked the TPA-induced p21 expression.	Tetradecanoylphorbol Acetate	118-121	cyclin dependent kinase inhibitor 1A	Homo sapiens	130-133
16868480-11	2006	Small interferring RNA targeted to p21 blocked TPA-induced p21 protein expression but not TPA-induced cell growth arrest.	Tetradecanoylphorbol Acetate	47-50	cyclin dependent kinase inhibitor 1A	Homo sapiens	35-38
16868480-11	2006	Small interferring RNA targeted to p21 blocked TPA-induced p21 protein expression but not TPA-induced cell growth arrest.	Tetradecanoylphorbol Acetate	47-50	cyclin dependent kinase inhibitor 1A	Homo sapiens	59-62
16868480-12	2006	CONCLUSIONS: TPA-induced p21 expression is mediated by the MEK/ERK pathway but is not involved in TPA-induced growth inhibition.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	25-28
16868480-12	2006	CONCLUSIONS: TPA-induced p21 expression is mediated by the MEK/ERK pathway but is not involved in TPA-induced growth inhibition.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase kinase 7	Homo sapiens	59-62
16868480-12	2006	CONCLUSIONS: TPA-induced p21 expression is mediated by the MEK/ERK pathway but is not involved in TPA-induced growth inhibition.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 1	Homo sapiens	63-66
16868480-13	2006	In contrast, cyclin A and cyclin B are likely involved in TPA-induced G2/M arrest because both proteins are involved in S phase and G2/M transition during cell proliferation.	Tetradecanoylphorbol Acetate	58-61	cyclin A2	Homo sapiens	13-21
16169661-0	2006	Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase kinase 7	Homo sapiens	55-58
16169661-0	2006	Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 1	Homo sapiens	59-62
16169661-1	2006	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is a well-known activator of both protein kinase C (PKC) and mitogen activated protein kinase (MAPK) signal cascade triggering a lot of effects in many non-tumor and tumor cells.	Tetradecanoylphorbol Acetate	19-55	protein kinase C alpha	Homo sapiens	114-117
16169661-1	2006	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is a well-known activator of both protein kinase C (PKC) and mitogen activated protein kinase (MAPK) signal cascade triggering a lot of effects in many non-tumor and tumor cells.	Tetradecanoylphorbol Acetate	57-60	protein kinase C alpha	Homo sapiens	114-117
16169661-2	2006	We have reported activation of PKCalpha isozyme was specifically required for TPA-induced ERK (MAPK) signaling that mediated gene expressions of the CDK inhibitors p15(INK4b) and p16 (INK4a) leading to growth inhibition of hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	78-81	protein kinase C alpha	Homo sapiens	31-39
16169661-2	2006	We have reported activation of PKCalpha isozyme was specifically required for TPA-induced ERK (MAPK) signaling that mediated gene expressions of the CDK inhibitors p15(INK4b) and p16 (INK4a) leading to growth inhibition of hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 1	Homo sapiens	90-93
16169661-2	2006	We have reported activation of PKCalpha isozyme was specifically required for TPA-induced ERK (MAPK) signaling that mediated gene expressions of the CDK inhibitors p15(INK4b) and p16 (INK4a) leading to growth inhibition of hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	78-81	cyclin dependent kinase inhibitor 2B	Homo sapiens	164-173
16631161-5	2006	Our results indicate that, prior to inducing a state of competency for plasminogen-dependent scattering, PMA triggers an ordered succession of events where upregulation of the activity of u-PA precedes proteolysis of u-PAR and active degradation of the extracellular matrix (ECM).	Tetradecanoylphorbol Acetate	105-108	plasminogen activator, urokinase	Homo sapiens	188-192
16169661-2	2006	We have reported activation of PKCalpha isozyme was specifically required for TPA-induced ERK (MAPK) signaling that mediated gene expressions of the CDK inhibitors p15(INK4b) and p16 (INK4a) leading to growth inhibition of hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	78-81	cyclin dependent kinase inhibitor 2A	Homo sapiens	179-182
16169661-2	2006	We have reported activation of PKCalpha isozyme was specifically required for TPA-induced ERK (MAPK) signaling that mediated gene expressions of the CDK inhibitors p15(INK4b) and p16 (INK4a) leading to growth inhibition of hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	78-81	cyclin dependent kinase inhibitor 2A	Homo sapiens	184-189
16169661-9	2006	Consistently, Western blot of Phospho(ser-218/222)-MEK demonstrated that phosphorylation of MEK-1 was greatly induced by 50nM TPA, which can be prevented by the PKC inhibitor Bisindolylmaleimides II.	Tetradecanoylphorbol Acetate	126-129	mitogen-activated protein kinase kinase 7	Homo sapiens	51-54
16169661-10	2006	Moreover, pretreatment of the MEK1/2 inhibitor, but not c-Raf inhibitor prevented the TPA-induced ERK phosphorylation, gene expression of p15(INK4b) and p16 (INK4a) and growth inhibition of HepG2.	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase 1	Homo sapiens	98-101
16169661-10	2006	Moreover, pretreatment of the MEK1/2 inhibitor, but not c-Raf inhibitor prevented the TPA-induced ERK phosphorylation, gene expression of p15(INK4b) and p16 (INK4a) and growth inhibition of HepG2.	Tetradecanoylphorbol Acetate	86-89	cyclin dependent kinase inhibitor 2B	Homo sapiens	138-141
16169661-10	2006	Moreover, pretreatment of the MEK1/2 inhibitor, but not c-Raf inhibitor prevented the TPA-induced ERK phosphorylation, gene expression of p15(INK4b) and p16 (INK4a) and growth inhibition of HepG2.	Tetradecanoylphorbol Acetate	86-89	cyclin dependent kinase inhibitor 2B	Homo sapiens	142-147
16169661-10	2006	Moreover, pretreatment of the MEK1/2 inhibitor, but not c-Raf inhibitor prevented the TPA-induced ERK phosphorylation, gene expression of p15(INK4b) and p16 (INK4a) and growth inhibition of HepG2.	Tetradecanoylphorbol Acetate	86-89	cyclin dependent kinase inhibitor 2A	Homo sapiens	153-156
16169661-10	2006	Moreover, pretreatment of the MEK1/2 inhibitor, but not c-Raf inhibitor prevented the TPA-induced ERK phosphorylation, gene expression of p15(INK4b) and p16 (INK4a) and growth inhibition of HepG2.	Tetradecanoylphorbol Acetate	86-89	cyclin dependent kinase inhibitor 2A	Homo sapiens	158-163
16169661-14	2006	Taken together, we conclude that PKCalpha may activate MEK, independently of Raf and Ras, to trigger sustained ERK (MAPK) signaling and cell cycle arrest of HepG2 induced by TPA.	Tetradecanoylphorbol Acetate	174-177	protein kinase C alpha	Homo sapiens	33-41
16169661-14	2006	Taken together, we conclude that PKCalpha may activate MEK, independently of Raf and Ras, to trigger sustained ERK (MAPK) signaling and cell cycle arrest of HepG2 induced by TPA.	Tetradecanoylphorbol Acetate	174-177	mitogen-activated protein kinase kinase 7	Homo sapiens	55-58
16910781-4	2006	12-O-Tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C and an inducer of NFkappaB and AP-1, protected the cells.	Tetradecanoylphorbol Acetate	0-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-103
16910781-4	2006	12-O-Tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C and an inducer of NFkappaB and AP-1, protected the cells.	Tetradecanoylphorbol Acetate	38-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-103
16474181-4	2006	Resveratrol-suppressed phosphorylation and subsequent degradation of IkappaBalpha, thereby inhibiting activation of nuclear factor-kappaB (NF-kappaB) in TPA-stimulated mouse skin.	Tetradecanoylphorbol Acetate	153-156	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	69-81
16870006-0	2006	Soya isoflavones suppress phorbol 12-myristate 13-acetate-induced COX-2 expression in MCF-7 cells.	Tetradecanoylphorbol Acetate	26-57	prostaglandin-endoperoxide synthase 2	Homo sapiens	66-71
16870006-4	2006	Genistein, daidzein and equol were found to inhibit COX-2 expression induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	80-111	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-57
16870006-4	2006	Genistein, daidzein and equol were found to inhibit COX-2 expression induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	113-116	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-57
16474181-4	2006	Resveratrol-suppressed phosphorylation and subsequent degradation of IkappaBalpha, thereby inhibiting activation of nuclear factor-kappaB (NF-kappaB) in TPA-stimulated mouse skin.	Tetradecanoylphorbol Acetate	153-156	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	116-137
16474181-4	2006	Resveratrol-suppressed phosphorylation and subsequent degradation of IkappaBalpha, thereby inhibiting activation of nuclear factor-kappaB (NF-kappaB) in TPA-stimulated mouse skin.	Tetradecanoylphorbol Acetate	153-156	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	139-148
16474181-6	2006	Resveratrol blunted TPA-induced phosphorylation of p65 and its interaction with CBP/p300, rendering NF-kappaB transcriptionally inactive.	Tetradecanoylphorbol Acetate	20-23	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	100-109
16685461-7	2006	Western blot analysis of connexin 43 in a membrane-enriched fraction of WB-F344 cells treated with thioridazine revealed decreased amounts of unphosphorylated connexin 43, and appearance of a phosphorylated connexin 43 band that co-migrated with a "hyperphosphorylated" connexin 43 band present in TPA-inhibited cells.	Tetradecanoylphorbol Acetate	298-301	gap junction protein, alpha 1	Rattus norvegicus	25-36
16888195-4	2006	Despite its positive coupling to cAMP pathway, GnRH counteracted PACAP induction of cAMP and this effect was mimicked by the PKC activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	139-170	adenylate cyclase activating polypeptide 1	Mus musculus	65-70
16474181-7	2006	To get further insights into the molecular basis of NF-kappaB inactivation by resveratrol, we examined the role of IkappaB kinase (IKK) in mediating TPA-induced activation of NF-kappaB and COX-2 expression.	Tetradecanoylphorbol Acetate	149-152	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	175-184
16888195-4	2006	Despite its positive coupling to cAMP pathway, GnRH counteracted PACAP induction of cAMP and this effect was mimicked by the PKC activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	172-175	adenylate cyclase activating polypeptide 1	Mus musculus	65-70
16474181-9	2006	Topical application of Bay 11-7082 also abrogated TPA-induced NF-kappaB activation and COX-2 expression, supporting the involvement of IKK in TPA-induced COX-2 expression.	Tetradecanoylphorbol Acetate	50-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	62-71
16474181-9	2006	Topical application of Bay 11-7082 also abrogated TPA-induced NF-kappaB activation and COX-2 expression, supporting the involvement of IKK in TPA-induced COX-2 expression.	Tetradecanoylphorbol Acetate	142-145	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	62-71
16474181-10	2006	Taken together, the above findings suggest that resveratrol targets IKK in blocking TPA-induced NF-kappaB activation and COX-2 expression in mouse skin in vivo.	Tetradecanoylphorbol Acetate	84-87	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	96-105
16630555-2	2006	A human monocytic cell line, THP-1, differentiated to be neutrophil-like cells generated superoxide with increase in intracellular Ca2+ concentration when stimulated with formyl-methionyl-leucyl-phenylalanine (fMLP) whereas PMA, phorbol ester-stimulated superoxide response occurred without change in [Ca2+]i.	Tetradecanoylphorbol Acetate	224-227	GLI family zinc finger 2	Homo sapiens	29-34
16416023-4	2006	Activation of PKC by phorbol myristate acetate (PMA) (100 nM) for 30 min induced intercellular gap formation and fragmentation of VE-cadherin immunoreactivity in WT but not in caveolin-1-deficient monolayers.	Tetradecanoylphorbol Acetate	48-51	cadherin 5	Mus musculus	130-141
16618699-5	2006	Pretreatment of JB6 cells with C3G inhibited UVB- and TPA-induced transactivation of NF-kappaB and AP-1 and expression of cyclooxygenase-2 and tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	54-57	prostaglandin-endoperoxide synthase 2	Homo sapiens	122-170
16611631-5	2006	Stimulation of neuroblastoma cells with IGF1 or TPA decreases GSK3 activity concomitantly with CRMP2 and CRMP4 phosphorylation.	Tetradecanoylphorbol Acetate	48-51	dihydropyrimidinase like 2	Homo sapiens	95-100
16368122-6	2006	Arsenic/TPA also decreased the expression of BRCA1, betaine-homocysteine methyltransferase, CYP7B1, CYP2F2 and insulin-like growth factor-1 in normal and cancerous livers.	Tetradecanoylphorbol Acetate	8-11	betaine-homocysteine methyltransferase	Mus musculus	52-90
16733850-5	2006	RESULTS: RT-QPCR validated the increased expression of LCN2 (lipocalin 2) and for the first time PLAT (tissue-type plasminogen activator or tPA) in malignant pancreas as compared with normal pancreas.	Tetradecanoylphorbol Acetate	140-143	plasminogen activator, tissue type	Homo sapiens	97-101
16761100-3	2006	Our results showed that both H2O2 and O3 were produced in human leukemia THP-1 monocytes incubated with human immunoglobulin G and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	131-156	GLI family zinc finger 2	Homo sapiens	73-78
16416023-4	2006	Activation of PKC by phorbol myristate acetate (PMA) (100 nM) for 30 min induced intercellular gap formation and fragmentation of VE-cadherin immunoreactivity in WT but not in caveolin-1-deficient monolayers.	Tetradecanoylphorbol Acetate	21-46	cadherin 5	Mus musculus	130-141
16773182-7	2006	Inhibitors of mitogen-activated protein/extracellular signal regulated kinase (MEK), such as ERK inhibitor PD98059 and JNK inhibitors dicumarol and SP60015, but not p38 inhibitor SB203580, inhibited PMA-induced MUC5AC reporter activity.	Tetradecanoylphorbol Acetate	199-202	mitogen-activated protein kinase kinase 7	Homo sapiens	79-82
16773182-7	2006	Inhibitors of mitogen-activated protein/extracellular signal regulated kinase (MEK), such as ERK inhibitor PD98059 and JNK inhibitors dicumarol and SP60015, but not p38 inhibitor SB203580, inhibited PMA-induced MUC5AC reporter activity.	Tetradecanoylphorbol Acetate	199-202	mitogen-activated protein kinase 1	Homo sapiens	93-96
16773182-7	2006	Inhibitors of mitogen-activated protein/extracellular signal regulated kinase (MEK), such as ERK inhibitor PD98059 and JNK inhibitors dicumarol and SP60015, but not p38 inhibitor SB203580, inhibited PMA-induced MUC5AC reporter activity.	Tetradecanoylphorbol Acetate	199-202	mitogen-activated protein kinase 8	Homo sapiens	119-122
16607034-6	2006	Dibutyryl cyclic AMP and phorbol 12-myristate 13-acetate, which differentiate apoA-I-mediated cellular lipid release between 293/2c and 293/6c, also exhibited the same differential effects on the SAA-mediated reactions.	Tetradecanoylphorbol Acetate	25-56	apolipoprotein A1	Homo sapiens	78-84
16608922-5	2006	TPA, 3-MC, BHA, and PB reduced HNF1alpha mRNA levels in preconfluent and confluent cells and caused marked reductions in luciferase activity in pGSTA1-1591-luc transfectants.	Tetradecanoylphorbol Acetate	0-3	HNF1 homeobox A	Homo sapiens	31-40
16630555-2	2006	A human monocytic cell line, THP-1, differentiated to be neutrophil-like cells generated superoxide with increase in intracellular Ca2+ concentration when stimulated with formyl-methionyl-leucyl-phenylalanine (fMLP) whereas PMA, phorbol ester-stimulated superoxide response occurred without change in [Ca2+]i.	Tetradecanoylphorbol Acetate	224-227	formyl peptide receptor 1	Homo sapiens	210-214
16582932-8	2006	In contrast, mGluR4 internalized when the protein kinase C (PKC) pathway was activated either by phorbol-12-myristate-13-acetate (PMA) or by the activation of the Galphaq-coupled, neurokinin 3 receptor (NK3R) when co-expressed.	Tetradecanoylphorbol Acetate	97-128	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	13-19
16582932-8	2006	In contrast, mGluR4 internalized when the protein kinase C (PKC) pathway was activated either by phorbol-12-myristate-13-acetate (PMA) or by the activation of the Galphaq-coupled, neurokinin 3 receptor (NK3R) when co-expressed.	Tetradecanoylphorbol Acetate	130-133	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	13-19
16740738-2	2006	Here, we showed that paxillin plays a key role in skin cell transformation induced by epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	119-155	paxillin	Mus musculus	21-29
16740738-2	2006	Here, we showed that paxillin plays a key role in skin cell transformation induced by epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	157-160	paxillin	Mus musculus	21-29
16740738-4	2006	The si-paxillin cells displayed a dramatic suppression of cell proliferation and anchorage-independent cell transformation induced by EGF or TPA compared with si-mock control cells.	Tetradecanoylphorbol Acetate	141-144	paxillin	Mus musculus	7-15
16740738-6	2006	Importantly, knockdown of paxillin inhibited EGF- or TPA-induced c-Jun phosphorylation at Ser(63) and Ser(73).	Tetradecanoylphorbol Acetate	53-56	paxillin	Mus musculus	26-34
16753836-3	2006	EC-SOD also inhibited the induction of HB-EGF by 12-O-tetradecanoylphorbol-13-acetate (TPA) in RASMC by 60%.	Tetradecanoylphorbol Acetate	49-85	heparin-binding EGF-like growth factor	Rattus norvegicus	39-45
16740769-6	2006	RESULTS: Treatment of LNCaP cells with a combination of TPA and paclitaxel synergistically inhibited the growth and induced apoptosis in cultured LNCaP cells, and this treatment also induced a marked increase in phosphorylated c-Jun-NH2-kinase (JNK).	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase 8	Homo sapiens	227-243
16740769-6	2006	RESULTS: Treatment of LNCaP cells with a combination of TPA and paclitaxel synergistically inhibited the growth and induced apoptosis in cultured LNCaP cells, and this treatment also induced a marked increase in phosphorylated c-Jun-NH2-kinase (JNK).	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase 8	Homo sapiens	245-248
16728574-14	2006	However, as both COX-2 and VEGF-C were induced by the tumour promoter phorbol 12-myristate 13-acetate (PMA), the same factors may control them both.	Tetradecanoylphorbol Acetate	103-106	prostaglandin-endoperoxide synthase 2	Homo sapiens	17-22
16728574-14	2006	However, as both COX-2 and VEGF-C were induced by the tumour promoter phorbol 12-myristate 13-acetate (PMA), the same factors may control them both.	Tetradecanoylphorbol Acetate	103-106	vascular endothelial growth factor C	Homo sapiens	27-33
16728574-14	2006	However, as both COX-2 and VEGF-C were induced by the tumour promoter phorbol 12-myristate 13-acetate (PMA), the same factors may control them both.	Tetradecanoylphorbol Acetate	70-101	prostaglandin-endoperoxide synthase 2	Homo sapiens	17-22
16728574-14	2006	However, as both COX-2 and VEGF-C were induced by the tumour promoter phorbol 12-myristate 13-acetate (PMA), the same factors may control them both.	Tetradecanoylphorbol Acetate	70-101	vascular endothelial growth factor C	Homo sapiens	27-33
16753836-3	2006	EC-SOD also inhibited the induction of HB-EGF by 12-O-tetradecanoylphorbol-13-acetate (TPA) in RASMC by 60%.	Tetradecanoylphorbol Acetate	87-90	heparin-binding EGF-like growth factor	Rattus norvegicus	39-45
16628192-7	2006	Increased HZF1 mRNA expression was observed following erythroid differentiation of K562 cells induced by hemin or megakaryocytic differentiation of K562 cells induced by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	170-195	zinc finger protein 123, pseudogene	Homo sapiens	10-14
16628192-7	2006	Increased HZF1 mRNA expression was observed following erythroid differentiation of K562 cells induced by hemin or megakaryocytic differentiation of K562 cells induced by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	197-200	zinc finger protein 123, pseudogene	Homo sapiens	10-14
16705159-5	2006	Other ERK activators, phorbol 12-myristate 13-acetate and epidermal growth factor, also stimulate phosphorylation of Ser523.	Tetradecanoylphorbol Acetate	22-53	mitogen-activated protein kinase 3	Homo sapiens	6-9
16376386-0	2006	Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappaB activation in U937 cells.	Tetradecanoylphorbol Acetate	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	31-35
16434970-6	2006	In addition, several JNK upstream activators, including the phorbol ester TPA, anisomycin and MAPK kinase kinase-1 (MEKK1), phosphorylated Nur77 and induced its nuclear export.	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 8	Homo sapiens	21-24
16434970-6	2006	In addition, several JNK upstream activators, including the phorbol ester TPA, anisomycin and MAPK kinase kinase-1 (MEKK1), phosphorylated Nur77 and induced its nuclear export.	Tetradecanoylphorbol Acetate	74-77	nuclear receptor subfamily 4 group A member 1	Homo sapiens	139-144
16343552-4	2006	TPA induced an increased expression and activity of the ubiquitin-proteasome pathway, as evidenced by an increased functional activity, and increased expression of the 20S proteasome alpha-subunits, the 19S subunits MSS1 and p42, as well as the ubiquitin conjugating enzyme E2(14k), also with a maximal effect at a concentration of 25 nM and with a 3 h incubation time.	Tetradecanoylphorbol Acetate	0-3	ubiquitin-conjugating enzyme E2B	Mus musculus	274-280
16343552-8	2006	TPA also induced degradation of the inhibitory protein, I-kappaBalpha, and increased nuclear accumulation of nuclear factor-kappaB (NF-kappaB) at the same time and concentrations as those inducing proteasome expression.	Tetradecanoylphorbol Acetate	0-3	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	56-69
16481048-8	2006	In addition, CD5+/Mac-1- peritoneal B cells responded to PMA, a mitogen that stimulates B-1 cells but not B-2 cells, and not to anti-Ig, that stimulates B-2 cells but not B-1 cells.	Tetradecanoylphorbol Acetate	57-60	integrin alpha M	Mus musculus	18-23
16713561-6	2006	In Cyld+/+ keratinocytes, TPA or UV light triggers the translocation of Cyld from the cytoplasm to the perinuclear region, where Cyld binds and deubiquitinates Bcl-3, thereby preventing nuclear accumulation of Bcl-3 and p50/Bcl-3- or p52/Bcl-3-dependent proliferation.	Tetradecanoylphorbol Acetate	26-29	B cell leukemia/lymphoma 3	Mus musculus	160-165
16713561-6	2006	In Cyld+/+ keratinocytes, TPA or UV light triggers the translocation of Cyld from the cytoplasm to the perinuclear region, where Cyld binds and deubiquitinates Bcl-3, thereby preventing nuclear accumulation of Bcl-3 and p50/Bcl-3- or p52/Bcl-3-dependent proliferation.	Tetradecanoylphorbol Acetate	26-29	B cell leukemia/lymphoma 3	Mus musculus	210-215
16713561-6	2006	In Cyld+/+ keratinocytes, TPA or UV light triggers the translocation of Cyld from the cytoplasm to the perinuclear region, where Cyld binds and deubiquitinates Bcl-3, thereby preventing nuclear accumulation of Bcl-3 and p50/Bcl-3- or p52/Bcl-3-dependent proliferation.	Tetradecanoylphorbol Acetate	26-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	220-223
16713561-6	2006	In Cyld+/+ keratinocytes, TPA or UV light triggers the translocation of Cyld from the cytoplasm to the perinuclear region, where Cyld binds and deubiquitinates Bcl-3, thereby preventing nuclear accumulation of Bcl-3 and p50/Bcl-3- or p52/Bcl-3-dependent proliferation.	Tetradecanoylphorbol Acetate	26-29	B cell leukemia/lymphoma 3	Mus musculus	210-215
16713561-6	2006	In Cyld+/+ keratinocytes, TPA or UV light triggers the translocation of Cyld from the cytoplasm to the perinuclear region, where Cyld binds and deubiquitinates Bcl-3, thereby preventing nuclear accumulation of Bcl-3 and p50/Bcl-3- or p52/Bcl-3-dependent proliferation.	Tetradecanoylphorbol Acetate	26-29	B cell leukemia/lymphoma 3	Mus musculus	210-215
16622456-6	2006	In this study, we detected sequences directed against COX-2 mRNA, that potently downregulate COX-2 gene expression and inhibit phorbol 12-myristate 13-acetate-induced angiogenesis in vitro in a specific, nontoxic manner.	Tetradecanoylphorbol Acetate	127-158	prostaglandin-endoperoxide synthase 2	Homo sapiens	54-59
16543267-13	2006	Conversely, the PKC agonist phorbol 12-myristate 13-acetate mimicked the Ang II effects by triggering APs.	Tetradecanoylphorbol Acetate	28-59	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	73-79
16622456-6	2006	In this study, we detected sequences directed against COX-2 mRNA, that potently downregulate COX-2 gene expression and inhibit phorbol 12-myristate 13-acetate-induced angiogenesis in vitro in a specific, nontoxic manner.	Tetradecanoylphorbol Acetate	127-158	prostaglandin-endoperoxide synthase 2	Homo sapiens	93-98
16498671-1	2006	BACKGROUND: We previously reported a flow cytometry technique to monitor pharmacodynamic effects of the raf kinase inhibitor BAY 43-9006 based on the ability of phorbol ester (PMA) to phosphorylate extracellular-regulated kinase (ERK) in peripheral blood (Chow et al., Cytometry 2001;46:72-78).	Tetradecanoylphorbol Acetate	176-179	mitogen-activated protein kinase 1	Homo sapiens	198-228
16361367-8	2006	The PKC activator phorbol 12-myristate 13-acetate (2 microM) increased the cumulative open probability of the mitoKATP channel previously inhibited by ATP (P &lt; 0.05), but its inactive analog 4alpha-phorbol 12,13-didecanoate had no effect.	Tetradecanoylphorbol Acetate	18-49	proline rich transmembrane protein 2	Homo sapiens	4-7
16484594-3	2006	METHODS AND RESULTS: Am80 suppressed IL-6 production induced by 12-myristate 13-acetate (PMA) or angiotensin II in mouse Raw264 macrophages.	Tetradecanoylphorbol Acetate	89-92	interleukin 6	Mus musculus	37-41
16651411-5	2006	Furthermore, whereas both estradiol and TPA increased trefoil factor 1 (TFF1) mRNA levels in these cells, only TPA-induced and not estradiol-induced TFF1 expression was inhibited by the H3 kinase mitogen and stress activated protein kinase (MSK) inhibitor H89 and MAPK kinase inhibitor UO126, showing the involvement of the Ras/MAPK following TPA induction.	Tetradecanoylphorbol Acetate	40-43	trefoil factor 1	Homo sapiens	54-70
16651411-5	2006	Furthermore, whereas both estradiol and TPA increased trefoil factor 1 (TFF1) mRNA levels in these cells, only TPA-induced and not estradiol-induced TFF1 expression was inhibited by the H3 kinase mitogen and stress activated protein kinase (MSK) inhibitor H89 and MAPK kinase inhibitor UO126, showing the involvement of the Ras/MAPK following TPA induction.	Tetradecanoylphorbol Acetate	40-43	trefoil factor 1	Homo sapiens	72-76
16651411-5	2006	Furthermore, whereas both estradiol and TPA increased trefoil factor 1 (TFF1) mRNA levels in these cells, only TPA-induced and not estradiol-induced TFF1 expression was inhibited by the H3 kinase mitogen and stress activated protein kinase (MSK) inhibitor H89 and MAPK kinase inhibitor UO126, showing the involvement of the Ras/MAPK following TPA induction.	Tetradecanoylphorbol Acetate	111-114	mitogen-activated protein kinase 3	Homo sapiens	264-268
16651411-5	2006	Furthermore, whereas both estradiol and TPA increased trefoil factor 1 (TFF1) mRNA levels in these cells, only TPA-induced and not estradiol-induced TFF1 expression was inhibited by the H3 kinase mitogen and stress activated protein kinase (MSK) inhibitor H89 and MAPK kinase inhibitor UO126, showing the involvement of the Ras/MAPK following TPA induction.	Tetradecanoylphorbol Acetate	111-114	mitogen-activated protein kinase 3	Homo sapiens	328-332
16651411-5	2006	Furthermore, whereas both estradiol and TPA increased trefoil factor 1 (TFF1) mRNA levels in these cells, only TPA-induced and not estradiol-induced TFF1 expression was inhibited by the H3 kinase mitogen and stress activated protein kinase (MSK) inhibitor H89 and MAPK kinase inhibitor UO126, showing the involvement of the Ras/MAPK following TPA induction.	Tetradecanoylphorbol Acetate	111-114	mitogen-activated protein kinase 3	Homo sapiens	264-268
16651411-5	2006	Furthermore, whereas both estradiol and TPA increased trefoil factor 1 (TFF1) mRNA levels in these cells, only TPA-induced and not estradiol-induced TFF1 expression was inhibited by the H3 kinase mitogen and stress activated protein kinase (MSK) inhibitor H89 and MAPK kinase inhibitor UO126, showing the involvement of the Ras/MAPK following TPA induction.	Tetradecanoylphorbol Acetate	111-114	mitogen-activated protein kinase 3	Homo sapiens	328-332
16651411-6	2006	Mutation of the activator protein 1 (AP-1) binding site abrogated the TPA-induced transcriptional response of the luciferase reporter gene under the control of the TFF1 promoter, showing the requirement for the AP-1 site.	Tetradecanoylphorbol Acetate	70-73	trefoil factor 1	Homo sapiens	164-168
16651411-9	2006	In the presence of TPA, whereas ERalpha was not bound to the promoter, a strong association of acetylated and/or phospho-H3, MSK1, and c-Jun was observed.	Tetradecanoylphorbol Acetate	19-22	estrogen receptor 1	Homo sapiens	32-39
16651411-10	2006	These results show that although both stimuli lead to TFF1 gene activation, estradiol and TPA exert their effects on TFF1 gene expression by different mechanisms.	Tetradecanoylphorbol Acetate	90-93	trefoil factor 1	Homo sapiens	117-121
16498671-1	2006	BACKGROUND: We previously reported a flow cytometry technique to monitor pharmacodynamic effects of the raf kinase inhibitor BAY 43-9006 based on the ability of phorbol ester (PMA) to phosphorylate extracellular-regulated kinase (ERK) in peripheral blood (Chow et al., Cytometry 2001;46:72-78).	Tetradecanoylphorbol Acetate	176-179	mitogen-activated protein kinase 1	Homo sapiens	230-233
16322071-6	2006	Gallic acid decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated pro-inflammatory cytokine gene expression and production such as TNF-alpha and IL-6 in human mast cells.	Tetradecanoylphorbol Acetate	26-57	tumor necrosis factor	Homo sapiens	164-173
16614396-7	2006	CP at the same doses inhibited TPA-induced nuclear translocation of p65 and subsequent DNA binding of NF-kappaB at 1 h by blocking the degradation of IkappaBalpha in mouse skin.	Tetradecanoylphorbol Acetate	31-34	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	150-162
16489124-3	2006	In addition, Dexras1 significantly reduced phorbol 12-myristate 13-acetate (PMA)-stimulated AC2 activity but did not alter Galpha(s)-mediated cAMP accumulation.	Tetradecanoylphorbol Acetate	43-74	adenylate cyclase 2	Homo sapiens	92-95
16489124-3	2006	In addition, Dexras1 significantly reduced phorbol 12-myristate 13-acetate (PMA)-stimulated AC2 activity but did not alter Galpha(s)-mediated cAMP accumulation.	Tetradecanoylphorbol Acetate	76-79	adenylate cyclase 2	Homo sapiens	92-95
16603514-6	2006	Here, a role is demonstrated for B-Raf/MEK/ERK signalling in TPA-induced reactivation of KSHV latent infection.	Tetradecanoylphorbol Acetate	61-64	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	33-38
16603514-8	2006	Transfection of BCBL-1 cells with B-Raf small interfering RNA inhibited TPA-induced KSHV lytic infection significantly.	Tetradecanoylphorbol Acetate	72-75	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
16322071-6	2006	Gallic acid decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated pro-inflammatory cytokine gene expression and production such as TNF-alpha and IL-6 in human mast cells.	Tetradecanoylphorbol Acetate	26-57	interleukin 6	Homo sapiens	178-182
16600024-8	2006	Phorbol myristate acetate-stimulated oxidative burst and IL-8 release by IL-1beta, lipopolysaccharide and GM-CSF in whole blood from mild but not severe asthmatics were inhibited after prednisolone.	Tetradecanoylphorbol Acetate	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
16734108-6	2006	Additionally, P-selectin MFI after activation of platelets with phorbol myristate acetate was 2.1-fold greater for dogs with IMHA than for healthy control dogs.	Tetradecanoylphorbol Acetate	64-89	selectin P	Canis lupus familiaris	14-24
16487490-0	2006	Involvement of tumor necrosis factor (TNF)-alpha in phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice.	Tetradecanoylphorbol Acetate	104-107	tumor necrosis factor	Mus musculus	15-48
16487490-3	2006	Topical application with TPA also induced increase in the level of TNF-alpha and prostagrandin E2 (PGE2) at the application site.	Tetradecanoylphorbol Acetate	25-28	tumor necrosis factor	Mus musculus	67-76
16487490-5	2006	An in vitro study with human keratinocytes as well as immunohistochemical analysis suggested that TNF-alpha induction in the skin might be produced by epidermis treated with TPA.	Tetradecanoylphorbol Acetate	174-177	tumor necrosis factor	Homo sapiens	98-107
16487490-8	2006	Taken together, these data demonstrate that the prolongation of the skin inflammation induced by TPA may be due to the sequential production of proinflammatory mediators such as eicosanoids and cytokines, and show for the first time the importance of TNF-alpha in the TPA-induced dermatitis especially at the stage where dermal edema is significant.	Tetradecanoylphorbol Acetate	97-100	tumor necrosis factor	Mus musculus	251-260
16600024-8	2006	Phorbol myristate acetate-stimulated oxidative burst and IL-8 release by IL-1beta, lipopolysaccharide and GM-CSF in whole blood from mild but not severe asthmatics were inhibited after prednisolone.	Tetradecanoylphorbol Acetate	0-25	interleukin 1 beta	Homo sapiens	73-81
16565508-4	2006	Taps represents a potential AP-1 target gene because TPA-induced expression in epidermal keratinocytes critically depends on c-Fos, and co-treatment with dexamethasone, a potent inhibitor of AP-1-mediated gene regulation, resulted in impaired activation of Taps expression.	Tetradecanoylphorbol Acetate	53-56	aspartic peptidase retroviral like 1	Homo sapiens	0-4
16565508-4	2006	Taps represents a potential AP-1 target gene because TPA-induced expression in epidermal keratinocytes critically depends on c-Fos, and co-treatment with dexamethasone, a potent inhibitor of AP-1-mediated gene regulation, resulted in impaired activation of Taps expression.	Tetradecanoylphorbol Acetate	53-56	aspartic peptidase retroviral like 1	Homo sapiens	257-261
16528027-5	2006	Here, the activation pathway was dissected and it was demonstrated that TPA induces KSHV reactivation via stimulation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 3	Homo sapiens	159-163
16528027-7	2006	Cells treated with MAPK/ERK inhibitors before TPA addition demonstrated repression of ERK1/2 phosphorylation, which was associated with a block of KSHV lytic-gene expression.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 3	Homo sapiens	86-92
16675300-6	2006	The delayed synthesis of PGE2 and PGF2alpha following the stimulation for 24 with a mixture of PMA and calcium ionophore A23187 was the highest in preadipocytes, reflecting the increased expression levels of cPLA2alpha and COX-2.	Tetradecanoylphorbol Acetate	95-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228
16257192-6	2006	Pre-incubation of hOAT4-expressing BeWo cells with phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), both of which are protein kinase C (PKC) activators, acutely inhibited the transport activity.	Tetradecanoylphorbol Acetate	51-82	solute carrier family 22 member 11	Homo sapiens	18-23
16257192-6	2006	Pre-incubation of hOAT4-expressing BeWo cells with phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), both of which are protein kinase C (PKC) activators, acutely inhibited the transport activity.	Tetradecanoylphorbol Acetate	84-87	solute carrier family 22 member 11	Homo sapiens	18-23
16184549-1	2006	Phorbol 12-myristate 13-acetate (PMA)-induced apoptosis of androgen sensitive LNCaP human prostate cancer cells is a well known phenomenon that involves prolonged translocation of multiple protein kinase C (PKC) isozymes to nonnuclear membranes.	Tetradecanoylphorbol Acetate	0-31	protein kinase C alpha	Homo sapiens	207-210
16635257-0	2006	12-O-tetradecanoyl-phorbol-13-acetate-dependent up-regulation of dopaminergic gene expression requires Ras and neurofibromin in human IMR-32 neuroblastoma.	Tetradecanoylphorbol Acetate	0-37	neurofibromin 1	Homo sapiens	111-124
16635257-3	2006	To investigate possible interactions between these two pathways before they converge on Raf activation, we evaluated whether phorbol ester (12-O-tetradecanoyl-phorbol-13-acetate, TPA)-dependent PKC activation required Ras for regulation of TH expression in IMR-32 cells.	Tetradecanoylphorbol Acetate	140-177	protein kinase C alpha	Homo sapiens	194-197
16635257-3	2006	To investigate possible interactions between these two pathways before they converge on Raf activation, we evaluated whether phorbol ester (12-O-tetradecanoyl-phorbol-13-acetate, TPA)-dependent PKC activation required Ras for regulation of TH expression in IMR-32 cells.	Tetradecanoylphorbol Acetate	179-182	protein kinase C alpha	Homo sapiens	194-197
16635257-4	2006	We found that long-term treatment with TPA, which induces down-regulation of PKC-alpha, led to induction of both protein and message levels of TH by autocrine factors.	Tetradecanoylphorbol Acetate	39-42	protein kinase C alpha	Homo sapiens	77-86
16480952-0	2006	Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cells.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 8	Homo sapiens	85-88
16480952-6	2006	Expression of involucrin and keratin 4 in response to TPA was attenuated by pretreatments with GF109203X and SP600125, but not PD98059, suggesting involvement of PKC and JNK in this response.	Tetradecanoylphorbol Acetate	54-57	mitogen-activated protein kinase 8	Homo sapiens	170-173
16480952-7	2006	Taken together, these results suggested that differentiation-associated genes were regulated by TPA-induced c-Jun/AP-1 mainly via a PKC/JNK pathway in esophageal cancer cell line KYSE450.	Tetradecanoylphorbol Acetate	96-99	mitogen-activated protein kinase 8	Homo sapiens	136-139
16529737-5	2006	In addition, sole activation of PKC using Phorbol 12-myristate 13-acetate (PMA) was sufficient for a synergistic interaction with EGF.	Tetradecanoylphorbol Acetate	42-73	LOC521832	Bos taurus	130-133
16529737-5	2006	In addition, sole activation of PKC using Phorbol 12-myristate 13-acetate (PMA) was sufficient for a synergistic interaction with EGF.	Tetradecanoylphorbol Acetate	75-78	LOC521832	Bos taurus	130-133
16434394-4	2006	Using human embryonic kidney 293 cells that are devoid of both endogenous PLM and NCX1, we first demonstrated that the exogenous NCX1 current (I(NaCa)) was increased by phorbol 12-myristate 13-acetate (PMA) but not by forskolin.	Tetradecanoylphorbol Acetate	169-200	FXYD domain containing ion transport regulator 1	Homo sapiens	74-77
16434394-4	2006	Using human embryonic kidney 293 cells that are devoid of both endogenous PLM and NCX1, we first demonstrated that the exogenous NCX1 current (I(NaCa)) was increased by phorbol 12-myristate 13-acetate (PMA) but not by forskolin.	Tetradecanoylphorbol Acetate	169-200	solute carrier family 8 member A1	Homo sapiens	82-86
16434394-4	2006	Using human embryonic kidney 293 cells that are devoid of both endogenous PLM and NCX1, we first demonstrated that the exogenous NCX1 current (I(NaCa)) was increased by phorbol 12-myristate 13-acetate (PMA) but not by forskolin.	Tetradecanoylphorbol Acetate	169-200	solute carrier family 8 member A1	Homo sapiens	129-133
16434394-4	2006	Using human embryonic kidney 293 cells that are devoid of both endogenous PLM and NCX1, we first demonstrated that the exogenous NCX1 current (I(NaCa)) was increased by phorbol 12-myristate 13-acetate (PMA) but not by forskolin.	Tetradecanoylphorbol Acetate	169-200	nascent polypeptide associated complex subunit alpha	Homo sapiens	145-149
16434394-4	2006	Using human embryonic kidney 293 cells that are devoid of both endogenous PLM and NCX1, we first demonstrated that the exogenous NCX1 current (I(NaCa)) was increased by phorbol 12-myristate 13-acetate (PMA) but not by forskolin.	Tetradecanoylphorbol Acetate	202-205	solute carrier family 8 member A1	Homo sapiens	129-133
16434394-4	2006	Using human embryonic kidney 293 cells that are devoid of both endogenous PLM and NCX1, we first demonstrated that the exogenous NCX1 current (I(NaCa)) was increased by phorbol 12-myristate 13-acetate (PMA) but not by forskolin.	Tetradecanoylphorbol Acetate	202-205	nascent polypeptide associated complex subunit alpha	Homo sapiens	145-149
16306087-0	2006	Antagonistic functions of tetradecanoyl phorbol acetate-inducible-sequence 11b and HuR in the hormonal regulation of vascular endothelial growth factor messenger ribonucleic acid stability by adrenocorticotropin.	Tetradecanoylphorbol Acetate	26-55	vascular endothelial growth factor A	Homo sapiens	117-151
16306087-4	2006	We further demonstrated that the zinc finger RNA-binding protein Tis11b (tetradecanoyl phorbol acetate-inducible-sequence 11b) destabilizes VEGF mRNA through its 3"-untranslated region (3"-UTR) and that Tis11b is involved in the decay phase of ACTH-induced VEGF mRNA expression.	Tetradecanoylphorbol Acetate	73-102	ZFP36 ring finger protein like 1	Homo sapiens	65-71
16306087-4	2006	We further demonstrated that the zinc finger RNA-binding protein Tis11b (tetradecanoyl phorbol acetate-inducible-sequence 11b) destabilizes VEGF mRNA through its 3"-untranslated region (3"-UTR) and that Tis11b is involved in the decay phase of ACTH-induced VEGF mRNA expression.	Tetradecanoylphorbol Acetate	73-102	vascular endothelial growth factor A	Homo sapiens	140-144
16306087-4	2006	We further demonstrated that the zinc finger RNA-binding protein Tis11b (tetradecanoyl phorbol acetate-inducible-sequence 11b) destabilizes VEGF mRNA through its 3"-untranslated region (3"-UTR) and that Tis11b is involved in the decay phase of ACTH-induced VEGF mRNA expression.	Tetradecanoylphorbol Acetate	73-102	ZFP36 ring finger protein like 1	Homo sapiens	203-209
16306087-4	2006	We further demonstrated that the zinc finger RNA-binding protein Tis11b (tetradecanoyl phorbol acetate-inducible-sequence 11b) destabilizes VEGF mRNA through its 3"-untranslated region (3"-UTR) and that Tis11b is involved in the decay phase of ACTH-induced VEGF mRNA expression.	Tetradecanoylphorbol Acetate	73-102	proopiomelanocortin	Homo sapiens	244-248
16306087-4	2006	We further demonstrated that the zinc finger RNA-binding protein Tis11b (tetradecanoyl phorbol acetate-inducible-sequence 11b) destabilizes VEGF mRNA through its 3"-untranslated region (3"-UTR) and that Tis11b is involved in the decay phase of ACTH-induced VEGF mRNA expression.	Tetradecanoylphorbol Acetate	73-102	vascular endothelial growth factor A	Homo sapiens	257-261
16184549-1	2006	Phorbol 12-myristate 13-acetate (PMA)-induced apoptosis of androgen sensitive LNCaP human prostate cancer cells is a well known phenomenon that involves prolonged translocation of multiple protein kinase C (PKC) isozymes to nonnuclear membranes.	Tetradecanoylphorbol Acetate	33-36	protein kinase C alpha	Homo sapiens	207-210
16184549-2	2006	We have shown recently that PMA-induced death of C4-2 cells, androgen hypersensitive derivatives of LNCaP cells, requires both PKCdelta and a redundant pathway that includes PKCs alpha and epsilon.	Tetradecanoylphorbol Acetate	28-31	protein kinase C alpha	Homo sapiens	174-196
16184549-5	2006	Moreover, overexpression of very high amounts of PKCepsilon sensitized LNCaP cells to induction of apoptosis by bryostatin 1, a non tumor-promoting activator and down-regulator of PKC isozymes that blocks PMA-induced apoptosis of parental LNCaP cells, mimicked our previous results with overexpression of PKCalpha in LNCaP cells.	Tetradecanoylphorbol Acetate	205-208	protein kinase C alpha	Homo sapiens	49-52
16431218-7	2006	In addition, these ERK1/2 mutants were activated by TPA when they were expressed in mammalian cells.	Tetradecanoylphorbol Acetate	52-55	mitogen-activated protein kinase 3	Homo sapiens	19-25
16107515-4	2006	Whole blood TNF production was induced by lipopolysaccharide (LPS), which binds to CD14/TLR4 on the monocyte surface, or by a combination of phorbol 12-myristate 13-acetate (PMA) and Ca(2+) ionophore A23187, which activates monocytes independently of cell surface receptors.	Tetradecanoylphorbol Acetate	141-172	tumor necrosis factor	Homo sapiens	12-15
16107515-4	2006	Whole blood TNF production was induced by lipopolysaccharide (LPS), which binds to CD14/TLR4 on the monocyte surface, or by a combination of phorbol 12-myristate 13-acetate (PMA) and Ca(2+) ionophore A23187, which activates monocytes independently of cell surface receptors.	Tetradecanoylphorbol Acetate	174-177	tumor necrosis factor	Homo sapiens	12-15
16278302-4	2006	beta-agonist and PGE2 also inhibited phorbol myristate acetate (PMA) + calcimycin-stimulated IFN-gamma and IL-2 (but not IL-13) production, suggesting that upstream CD3-initiated signaling is not the sole locus of PKA actions.	Tetradecanoylphorbol Acetate	37-62	interferon gamma	Homo sapiens	93-102
16619526-4	2006	Furthermore, the phorbol myristic acetate ester (PMA)-induced release of TNF-alpha in cultures of U937 cells was increased in the presence of AdAMP.	Tetradecanoylphorbol Acetate	49-52	tumor necrosis factor	Homo sapiens	73-82
16596993-4	2006	TPA-induced COX-2 activity also decreased in cells exposed to extract concentrations of 10, 20, 40, and 60 microg/mL.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
16571380-7	2006	In mechanistic terms, the transcriptional upregulation of SK-1 is dependent on PKC and the extracellular signal-regulated protein kinase (ERK) cascade since staurosporine and the MEK inhibitor U0126 abolish the TPA-induced SK-1 induction.	Tetradecanoylphorbol Acetate	211-214	mitogen-activated protein kinase 1	Homo sapiens	91-136
16571380-7	2006	In mechanistic terms, the transcriptional upregulation of SK-1 is dependent on PKC and the extracellular signal-regulated protein kinase (ERK) cascade since staurosporine and the MEK inhibitor U0126 abolish the TPA-induced SK-1 induction.	Tetradecanoylphorbol Acetate	211-214	mitogen-activated protein kinase 1	Homo sapiens	138-141
16571380-7	2006	In mechanistic terms, the transcriptional upregulation of SK-1 is dependent on PKC and the extracellular signal-regulated protein kinase (ERK) cascade since staurosporine and the MEK inhibitor U0126 abolish the TPA-induced SK-1 induction.	Tetradecanoylphorbol Acetate	211-214	mitogen-activated protein kinase kinase 7	Homo sapiens	179-182
16571380-11	2006	Interestingly, only depletion of PKC-alpha leads to a complete loss of TPA- and histamine-triggered SK-1 induction and cell migration.	Tetradecanoylphorbol Acetate	71-74	protein kinase C alpha	Homo sapiens	33-42
16278302-4	2006	beta-agonist and PGE2 also inhibited phorbol myristate acetate (PMA) + calcimycin-stimulated IFN-gamma and IL-2 (but not IL-13) production, suggesting that upstream CD3-initiated signaling is not the sole locus of PKA actions.	Tetradecanoylphorbol Acetate	37-62	interleukin 2	Homo sapiens	107-111
16278302-4	2006	beta-agonist and PGE2 also inhibited phorbol myristate acetate (PMA) + calcimycin-stimulated IFN-gamma and IL-2 (but not IL-13) production, suggesting that upstream CD3-initiated signaling is not the sole locus of PKA actions.	Tetradecanoylphorbol Acetate	64-67	interferon gamma	Homo sapiens	93-102
16278302-4	2006	beta-agonist and PGE2 also inhibited phorbol myristate acetate (PMA) + calcimycin-stimulated IFN-gamma and IL-2 (but not IL-13) production, suggesting that upstream CD3-initiated signaling is not the sole locus of PKA actions.	Tetradecanoylphorbol Acetate	64-67	interleukin 2	Homo sapiens	107-111
16510578-5	2006	Here, we report studies of HIF-1alpha induction following phorbol-12-myristate 13-acetate (PMA)-induced differentiation of monocytic U937 and THP1 cells.	Tetradecanoylphorbol Acetate	58-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-37
16244358-0	2006	Attenuation of BPDE-induced p53 accumulation by TPA is associated with a decrease in stability and phosphorylation of p53 and downregulation of NFkappaB activation: role of p38 MAP kinase.	Tetradecanoylphorbol Acetate	48-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	144-152
16244358-11	2006	We also observed that TPA or SB202190 attenuated BPDE-induced nuclear factor kappa B (NFkappaB) activation in JB6 Cl 41 cells harboring NFkappaB reporter plasmid.	Tetradecanoylphorbol Acetate	22-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-94
16244358-11	2006	We also observed that TPA or SB202190 attenuated BPDE-induced nuclear factor kappa B (NFkappaB) activation in JB6 Cl 41 cells harboring NFkappaB reporter plasmid.	Tetradecanoylphorbol Acetate	22-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	136-144
16244358-12	2006	To our knowledge this is the first report that TPA inhibits chemical carcinogen-induced NFkappaB activation.	Tetradecanoylphorbol Acetate	47-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-96
16244358-13	2006	Interference of TPA with BPDE-induced NFkappaB activation implicates abrogation of p53 function which has been discussed.	Tetradecanoylphorbol Acetate	16-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	38-46
16244358-14	2006	Overall, our data suggest that abrogation of BPDE-induced p53 response and of NFkappaB activation by TPA is mediated by impairment of the signaling pathway involving p38 MAPK.	Tetradecanoylphorbol Acetate	101-104	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	78-86
16510578-5	2006	Here, we report studies of HIF-1alpha induction following phorbol-12-myristate 13-acetate (PMA)-induced differentiation of monocytic U937 and THP1 cells.	Tetradecanoylphorbol Acetate	91-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-37
16601289-6	2006	In addition, the activation of ERK1/2 by GnRH-I or II was mimicked by phorbol-12-myristate 13-acetate, a PKC activator.	Tetradecanoylphorbol Acetate	70-101	mitogen-activated protein kinase 3	Homo sapiens	31-37
16553792-5	2006	Prior administration of PD98059 also antagonized the enhancing effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator that also causes ERK activation, on SGK phosphorylation and cAMP response element binding protein (CREB) phosphorylation.	Tetradecanoylphorbol Acetate	73-109	Eph receptor B1	Rattus norvegicus	163-166
16553792-5	2006	Prior administration of PD98059 also antagonized the enhancing effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator that also causes ERK activation, on SGK phosphorylation and cAMP response element binding protein (CREB) phosphorylation.	Tetradecanoylphorbol Acetate	111-114	Eph receptor B1	Rattus norvegicus	163-166
16698439-7	2006	T lymphocytes present in PBMCs and isolated CD4+ T lymphocytes stimulated with phorbol-12-myristate-13-acetate and ionomycin also induced MICA expression as assessed by Western blot, but only low levels were expressed at the cell surface.	Tetradecanoylphorbol Acetate	79-110	CD4 molecule	Homo sapiens	44-47
16342171-9	2006	Furthermore, we were able to demonstrate that U937 cells with downregulated MAF converted slower and to a significantly reduced extent to the macrophageal phenotype after TPA treatment.	Tetradecanoylphorbol Acetate	171-174	MAF bZIP transcription factor	Homo sapiens	76-79
16222701-7	2006	(iii) Furosemide inhibited MEK and ERK phosphorylation even when ERK phosphorylation was induced by direct activation of protein kinase C (PKC) by TPA, which bypasses early steps of the mitogenic cascade.	Tetradecanoylphorbol Acetate	147-150	mitogen-activated protein kinase 1	Homo sapiens	65-68
16484557-4	2006	Incubation of THP-1 cells with Hcy (200 micromol/L) for 72 h in the presence of phorbol 12-myristate 13-acetate (PMA) (10 nmol/L) caused a 37.8+/-5.2% increase in CD36 expression compared with PMA-stimulated cells without Hcy (P&lt;0.01).	Tetradecanoylphorbol Acetate	113-116	GLI family zinc finger 2	Homo sapiens	14-19
16245306-6	2006	Furthermore, PKC stimulation using phorbol 12-myristate 13-acetate (PMA) activated an apical membrane Cl- conductance that was blocked by the CFTR selective inhibitor, CFTRinh-172.	Tetradecanoylphorbol Acetate	35-66	CF transmembrane conductance regulator	Homo sapiens	142-146
16245306-6	2006	Furthermore, PKC stimulation using phorbol 12-myristate 13-acetate (PMA) activated an apical membrane Cl- conductance that was blocked by the CFTR selective inhibitor, CFTRinh-172.	Tetradecanoylphorbol Acetate	68-71	CF transmembrane conductance regulator	Homo sapiens	142-146
16562828-1	2006	Crude extracts of Witheringia solanacea leaves showed inhibition of NF-kappaB activation at 100 microg/mL induced by phorbol 12-myristate-13-acetate (PMA) in HeLa cells stably transfected with a luciferase reporter gene controlled by the IL-6 promoter.	Tetradecanoylphorbol Acetate	150-153	interleukin 6	Homo sapiens	238-242
16484557-4	2006	Incubation of THP-1 cells with Hcy (200 micromol/L) for 72 h in the presence of phorbol 12-myristate 13-acetate (PMA) (10 nmol/L) caused a 37.8+/-5.2% increase in CD36 expression compared with PMA-stimulated cells without Hcy (P&lt;0.01).	Tetradecanoylphorbol Acetate	80-111	GLI family zinc finger 2	Homo sapiens	14-19
16417568-3	2006	In HEK293 cells expressing NR1/NR2A, activation of endogenous PKC by 4beta-phorbol 12-myristate 13-acetate (PMA) increased NMDAR desensitization as evidenced by a reduced steady-state current without any change in peak.	Tetradecanoylphorbol Acetate	69-106	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	27-30
16417568-3	2006	In HEK293 cells expressing NR1/NR2A, activation of endogenous PKC by 4beta-phorbol 12-myristate 13-acetate (PMA) increased NMDAR desensitization as evidenced by a reduced steady-state current without any change in peak.	Tetradecanoylphorbol Acetate	69-106	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	31-35
16417568-3	2006	In HEK293 cells expressing NR1/NR2A, activation of endogenous PKC by 4beta-phorbol 12-myristate 13-acetate (PMA) increased NMDAR desensitization as evidenced by a reduced steady-state current without any change in peak.	Tetradecanoylphorbol Acetate	69-106	proline rich transmembrane protein 2	Homo sapiens	62-65
16417568-3	2006	In HEK293 cells expressing NR1/NR2A, activation of endogenous PKC by 4beta-phorbol 12-myristate 13-acetate (PMA) increased NMDAR desensitization as evidenced by a reduced steady-state current without any change in peak.	Tetradecanoylphorbol Acetate	108-111	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	27-30
16417568-3	2006	In HEK293 cells expressing NR1/NR2A, activation of endogenous PKC by 4beta-phorbol 12-myristate 13-acetate (PMA) increased NMDAR desensitization as evidenced by a reduced steady-state current without any change in peak.	Tetradecanoylphorbol Acetate	108-111	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	31-35
16417568-3	2006	In HEK293 cells expressing NR1/NR2A, activation of endogenous PKC by 4beta-phorbol 12-myristate 13-acetate (PMA) increased NMDAR desensitization as evidenced by a reduced steady-state current without any change in peak.	Tetradecanoylphorbol Acetate	108-111	proline rich transmembrane protein 2	Homo sapiens	62-65
16484557-4	2006	Incubation of THP-1 cells with Hcy (200 micromol/L) for 72 h in the presence of phorbol 12-myristate 13-acetate (PMA) (10 nmol/L) caused a 37.8+/-5.2% increase in CD36 expression compared with PMA-stimulated cells without Hcy (P&lt;0.01).	Tetradecanoylphorbol Acetate	193-196	GLI family zinc finger 2	Homo sapiens	14-19
16484557-7	2006	AGE also inhibited DiI-labeled OxLDL uptake into PMA-stimulated THP-1 cells by 85.6+/-2.8% (P&lt;0.01), but Hcy had no effects on it.	Tetradecanoylphorbol Acetate	49-52	GLI family zinc finger 2	Homo sapiens	64-69
16478997-2	2006	We now show that Sp1 that recruited HDAC1 to the Sp1/cJun complex was constitutively acetylated when cells were exposed to phorbol 12-myristate 13-acetate (PMA) (3 h).	Tetradecanoylphorbol Acetate	123-154	histone deacetylase 1	Homo sapiens	36-41
16478997-2	2006	We now show that Sp1 that recruited HDAC1 to the Sp1/cJun complex was constitutively acetylated when cells were exposed to phorbol 12-myristate 13-acetate (PMA) (3 h).	Tetradecanoylphorbol Acetate	156-159	histone deacetylase 1	Homo sapiens	36-41
16525579-4	2006	The rabbit myxoma viral serpin, Serp-1 inhibits urokinase- and tissue-type plasminogen activators (uPA and tPA), plasmin and factor Xa in vitro and exhibits remarkable anti-inflammatory activity in various animal models.	Tetradecanoylphorbol Acetate	107-110	alpha-2-antiplasmin	Oryctolagus cuniculus	24-30
16546974-0	2006	Differential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes.	Tetradecanoylphorbol Acetate	41-77	RAS guanyl releasing protein 1	Mus musculus	114-121
16546974-5	2006	We recently reported that the novel DAG receptor RasGRP1 is expressed in mouse keratinocytes and mediates TPA-induced Ras activation.	Tetradecanoylphorbol Acetate	106-109	RAS guanyl releasing protein 1	Mus musculus	49-56
16546974-7	2006	We found that whereas TPA induced translocation of RasGRP1 to both the plasma and internal membranes of the keratinocytes, bryostatin 1 recruited RasGRP1 only to internal membranes and the nuclear envelope.	Tetradecanoylphorbol Acetate	22-25	RAS guanyl releasing protein 1	Mus musculus	51-58
16546974-8	2006	In addition, TPA led to a concentration-dependent down-regulation of RasGRP1, whereas bryostatin 1 failed to induce full RasGRP1 down-regulation.	Tetradecanoylphorbol Acetate	13-16	RAS guanyl releasing protein 1	Mus musculus	69-76
16380081-9	2006	In addition, 12-O-tetradecanoyl-phorbol 13-acetate, a PKC activator, increased Smad7 mRNA expression.	Tetradecanoylphorbol Acetate	13-50	SMAD family member 7	Homo sapiens	79-84
16520553-1	2006	Elevated expression of protein casein kinase II (CKII) stimulated basal phospholipase D (PLD) activity as well as PMA-induced PLD activation in human U87 astroglioma cells.	Tetradecanoylphorbol Acetate	114-117	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-129
16371352-3	2006	We have now shown that inhibition of phosphatidylinositol 3-kinase by LY294002 suppresses both basal and phorbol myristate acetate-induced COX-2 expression in TMK-1 and MKN-28 gastric cancer cells.	Tetradecanoylphorbol Acetate	105-130	prostaglandin-endoperoxide synthase 2	Homo sapiens	139-144
16452183-6	2006	On comparison with all previous HK1.ras carcinomas, such TPA-induced carcinomas expressed atypical retention of keratin K1 and lack of K13, a unique marker profile exhibited by TPA-induced K14.cre/PTEN(flx/flx) papillomas that also lacked endogenous c-ras(Ha) activation.	Tetradecanoylphorbol Acetate	57-60	phosphatase and tensin homolog	Mus musculus	197-201
16455999-3	2006	PMA treatment also rapidly attenuated sustained Akt activation mediated by a carboxy truncated G-CSF receptor, expressed in patients with acute myeloid leukemia evolving from severe congenital neutropenia.	Tetradecanoylphorbol Acetate	0-3	AKT serine/threonine kinase 1	Homo sapiens	48-51
16455999-4	2006	The inhibitory effect of PMA was abolished by pretreatment of cells with specific PKC inhibitor GF109203X, suggesting that the PKC pathway negatively regulates Akt activation.	Tetradecanoylphorbol Acetate	25-28	AKT serine/threonine kinase 1	Homo sapiens	160-163
16455999-5	2006	Ro31-8820, a PKCepsilon inhibitor, also abrogated PMA-mediated inhibition of Akt activation, whereas rottlerin and Go6976, inhibitors of PKCdelta and PKCalphabetaI, respectively, exhibited no significant effects.	Tetradecanoylphorbol Acetate	50-53	AKT serine/threonine kinase 1	Homo sapiens	77-80
16338928-7	2006	Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity.	Tetradecanoylphorbol Acetate	31-67	protein kinase C, alpha	Mus musculus	24-27
16338928-7	2006	Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity.	Tetradecanoylphorbol Acetate	31-67	thymoma viral proto-oncogene 1	Mus musculus	98-101
16338928-7	2006	Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity.	Tetradecanoylphorbol Acetate	31-67	protein kinase C, alpha	Mus musculus	133-136
16338928-7	2006	Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity.	Tetradecanoylphorbol Acetate	31-67	thymoma viral proto-oncogene 1	Mus musculus	146-149
16338928-7	2006	Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity.	Tetradecanoylphorbol Acetate	69-72	protein kinase C, alpha	Mus musculus	24-27
16338928-7	2006	Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity.	Tetradecanoylphorbol Acetate	69-72	thymoma viral proto-oncogene 1	Mus musculus	98-101
16338928-7	2006	Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity.	Tetradecanoylphorbol Acetate	69-72	protein kinase C, alpha	Mus musculus	133-136
16338928-7	2006	Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity.	Tetradecanoylphorbol Acetate	69-72	thymoma viral proto-oncogene 1	Mus musculus	146-149
16338928-8	2006	TPA also attenuated IGF-1 and epidermal growth factor-induced phospho-Ser-473-Akt, reduced Akt kinase activity, and blocked IGF-1 protection from UVC-induced apoptosis.	Tetradecanoylphorbol Acetate	0-3	thymoma viral proto-oncogene 1	Mus musculus	78-81
16338928-8	2006	TPA also attenuated IGF-1 and epidermal growth factor-induced phospho-Ser-473-Akt, reduced Akt kinase activity, and blocked IGF-1 protection from UVC-induced apoptosis.	Tetradecanoylphorbol Acetate	0-3	thymoma viral proto-oncogene 1	Mus musculus	91-94
16338928-9	2006	The inhibition of Akt activity by TPA was reduced by inhibitors of protein phosphatase 2A, and TPA stimulated the association of phosphatase 2A with Akt.	Tetradecanoylphorbol Acetate	34-37	thymoma viral proto-oncogene 1	Mus musculus	18-21
16338928-9	2006	The inhibition of Akt activity by TPA was reduced by inhibitors of protein phosphatase 2A, and TPA stimulated the association of phosphatase 2A with Akt.	Tetradecanoylphorbol Acetate	95-98	thymoma viral proto-oncogene 1	Mus musculus	18-21
16338928-9	2006	The inhibition of Akt activity by TPA was reduced by inhibitors of protein phosphatase 2A, and TPA stimulated the association of phosphatase 2A with Akt.	Tetradecanoylphorbol Acetate	95-98	thymoma viral proto-oncogene 1	Mus musculus	149-152
16452183-6	2006	On comparison with all previous HK1.ras carcinomas, such TPA-induced carcinomas expressed atypical retention of keratin K1 and lack of K13, a unique marker profile exhibited by TPA-induced K14.cre/PTEN(flx/flx) papillomas that also lacked endogenous c-ras(Ha) activation.	Tetradecanoylphorbol Acetate	177-180	phosphatase and tensin homolog	Mus musculus	197-201
16446495-5	2006	Moreover, our findings showed a decrease in tumor necrosis factor (TNF-alpha)- or phorbol 12-myristate 13-acetate (PMA)-induced O2*- production in CD patient neutrophils adherent to fibronectin as compared with controls.	Tetradecanoylphorbol Acetate	82-113	fibronectin 1	Homo sapiens	182-193
16446495-5	2006	Moreover, our findings showed a decrease in tumor necrosis factor (TNF-alpha)- or phorbol 12-myristate 13-acetate (PMA)-induced O2*- production in CD patient neutrophils adherent to fibronectin as compared with controls.	Tetradecanoylphorbol Acetate	115-118	fibronectin 1	Homo sapiens	182-193
16374467-7	2006	Attenuated hyperplasia of interfollicular epidermis after topical application of the tumor promotor 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was observed in adult mice expressing the PPARalpha transgene.	Tetradecanoylphorbol Acetate	139-142	peroxisome proliferator activated receptor alpha	Mus musculus	186-195
16330529-5	2006	Similarly, activation of PKC with phorbol 12-myristate 13-acetate (PMA) depressed LPS-stimulated IL-12p40 secretion, and depletion of PKC augmented LPS-stimulated IL-12p40 secretion.	Tetradecanoylphorbol Acetate	34-65	protein kinase C, alpha	Mus musculus	25-28
16374467-7	2006	Attenuated hyperplasia of interfollicular epidermis after topical application of the tumor promotor 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was observed in adult mice expressing the PPARalpha transgene.	Tetradecanoylphorbol Acetate	100-137	peroxisome proliferator activated receptor alpha	Mus musculus	186-195
15899518-6	2006	The physiological process of B cell activation induced by (1) either the cross-linking of the B cell receptor (BCR) or CD40, (2) treatment with LPS, or PMA plus ionomycin, induces TNFalpha mRNA splicing in vitro.	Tetradecanoylphorbol Acetate	152-155	tumor necrosis factor	Mus musculus	180-188
16424122-5	2006	Using electrophoretic mobility shift assays, we found that the CLA mix reduced TPA-induced recruitment of nuclear proteins to a cAMP response element (CRE) in the COX-2 promoter and a consensus TPA-responsive element (TRE) in the collagenase-1 promoter.	Tetradecanoylphorbol Acetate	79-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	163-168
16330529-5	2006	Similarly, activation of PKC with phorbol 12-myristate 13-acetate (PMA) depressed LPS-stimulated IL-12p40 secretion, and depletion of PKC augmented LPS-stimulated IL-12p40 secretion.	Tetradecanoylphorbol Acetate	67-70	protein kinase C, alpha	Mus musculus	25-28
16210344-6	2006	In primary granulosa cell cultures, cGK II mRNA was induced by phorbol 12-myristate 13-acetate enhanced by adenoviral expression of PR-A and blocked by RU486 and trilostane.	Tetradecanoylphorbol Acetate	63-94	protein kinase, cGMP-dependent, type II	Mus musculus	36-42
16380122-3	2006	sibirica, on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in MCF10A human breast epithelial cells.	Tetradecanoylphorbol Acetate	77-113	prostaglandin-endoperoxide synthase 2	Homo sapiens	31-36
16404705-5	2006	A single topical application of TPA to ears of CD-1 mice induced a time- and dose-dependent increase in edema as well as formation of proinflammatory cytokine proteins interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in mouse ears.	Tetradecanoylphorbol Acetate	32-35	interleukin 1 beta	Mus musculus	187-195
16404705-5	2006	A single topical application of TPA to ears of CD-1 mice induced a time- and dose-dependent increase in edema as well as formation of proinflammatory cytokine proteins interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in mouse ears.	Tetradecanoylphorbol Acetate	32-35	interleukin 6	Mus musculus	201-214
16404705-5	2006	A single topical application of TPA to ears of CD-1 mice induced a time- and dose-dependent increase in edema as well as formation of proinflammatory cytokine proteins interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in mouse ears.	Tetradecanoylphorbol Acetate	32-35	interleukin 6	Mus musculus	216-220
16534736-0	2006	Inhibitory effects of ginsenoside-Rb1 on activation of the 12-O-tetradecanoylphorbol 13-acetate-induced cyclooxygenase-2 promoter.	Tetradecanoylphorbol Acetate	59-95	prostaglandin-endoperoxide synthase 2	Homo sapiens	104-120
16534736-1	2006	We studied the inhibitory effects of ginsenoside-Rb1 (1) on 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced transcriptional activation of the cyclooxygenase-2 (COX-2) promoter.	Tetradecanoylphorbol Acetate	60-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	145-161
16404705-5	2006	A single topical application of TPA to ears of CD-1 mice induced a time- and dose-dependent increase in edema as well as formation of proinflammatory cytokine proteins interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in mouse ears.	Tetradecanoylphorbol Acetate	32-35	interleukin 1 beta	Mus musculus	168-185
16505094-3	2006	PRL-3 mRNA levels were determined in several normal human endothelial cells exposed or unexposed to the phorbol ester phorbol 12-myristate 13-acetate (PMA) and in 27 human tumor cell lines.	Tetradecanoylphorbol Acetate	118-149	protein tyrosine phosphatase 4A3	Homo sapiens	0-5
16505094-3	2006	PRL-3 mRNA levels were determined in several normal human endothelial cells exposed or unexposed to the phorbol ester phorbol 12-myristate 13-acetate (PMA) and in 27 human tumor cell lines.	Tetradecanoylphorbol Acetate	151-154	protein tyrosine phosphatase 4A3	Homo sapiens	0-5
16505094-4	2006	In endothelial cells, PRL-3 mRNA expression was increased in human umbilical vascular endothelial cells and human microvascular endothelial cells (HMVEC) exposed to PMA.	Tetradecanoylphorbol Acetate	165-168	protein tyrosine phosphatase 4A3	Homo sapiens	22-27
16534736-1	2006	We studied the inhibitory effects of ginsenoside-Rb1 (1) on 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced transcriptional activation of the cyclooxygenase-2 (COX-2) promoter.	Tetradecanoylphorbol Acetate	60-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	163-168
16534736-1	2006	We studied the inhibitory effects of ginsenoside-Rb1 (1) on 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced transcriptional activation of the cyclooxygenase-2 (COX-2) promoter.	Tetradecanoylphorbol Acetate	98-101	prostaglandin-endoperoxide synthase 2	Homo sapiens	145-161
16534736-3	2006	Ginsenoside-Rb1 at 100 microM inhibited TPA-induced transcriptional activation of the COX-2 promoter.	Tetradecanoylphorbol Acetate	40-43	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-91
16534736-7	2006	In conclusion, ginsenoside-Rb1 inhibits TPA-induced COX-2 promoter activity through the nuclear factor interleukin-6 binding site and not through the nuclear factor-kappaB or cAMP-responsive elements.	Tetradecanoylphorbol Acetate	40-43	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-57
16380122-3	2006	sibirica, on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in MCF10A human breast epithelial cells.	Tetradecanoylphorbol Acetate	115-118	prostaglandin-endoperoxide synthase 2	Homo sapiens	31-36
16380122-4	2006	Treatment of MCF10A cells with TPA led to the expression of COX-2 and MMP-9.	Tetradecanoylphorbol Acetate	31-34	prostaglandin-endoperoxide synthase 2	Homo sapiens	60-65
16380122-5	2006	Hirsutenone at 12 microM inhibited the TPA-induced COX-2 expression at both the transcriptional and posttranscriptional levels.	Tetradecanoylphorbol Acetate	39-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	51-56
16309697-2	2006	Here, we show that phorbol 12 myristate 13-acetate (PMA) inhibited Ca2+ influx in wild-type but not PKC-theta-/- T cells, suggesting that PKC-theta plays a role in PMA-mediated inhibition of Ca2+ influx.	Tetradecanoylphorbol Acetate	19-50	protein kinase C theta	Homo sapiens	138-147
16309697-2	2006	Here, we show that phorbol 12 myristate 13-acetate (PMA) inhibited Ca2+ influx in wild-type but not PKC-theta-/- T cells, suggesting that PKC-theta plays a role in PMA-mediated inhibition of Ca2+ influx.	Tetradecanoylphorbol Acetate	52-55	protein kinase C theta	Homo sapiens	138-147
16380122-9	2006	Hirsutenone blocked the TPA-induced DNA binding of nuclear factor kappa B (NF-kappaB) and translocation of p65, the functionally active NF-kappaB subunit, to the nucleus.	Tetradecanoylphorbol Acetate	24-27	nuclear factor kappa B subunit 1	Homo sapiens	51-73
16380122-9	2006	Hirsutenone blocked the TPA-induced DNA binding of nuclear factor kappa B (NF-kappaB) and translocation of p65, the functionally active NF-kappaB subunit, to the nucleus.	Tetradecanoylphorbol Acetate	24-27	nuclear factor kappa B subunit 1	Homo sapiens	75-84
16380122-9	2006	Hirsutenone blocked the TPA-induced DNA binding of nuclear factor kappa B (NF-kappaB) and translocation of p65, the functionally active NF-kappaB subunit, to the nucleus.	Tetradecanoylphorbol Acetate	24-27	nuclear factor kappa B subunit 1	Homo sapiens	136-145
16380122-11	2006	Treatment of MCF10A cells with N-alpha-Tosyl-l-phenylalanine chloromethyl ketone, a specific inhibitor of NF-kappaB, reduced the TPA-induced expression of COX-2 and MMP-9.	Tetradecanoylphorbol Acetate	129-132	nuclear factor kappa B subunit 1	Homo sapiens	106-115
16380122-11	2006	Treatment of MCF10A cells with N-alpha-Tosyl-l-phenylalanine chloromethyl ketone, a specific inhibitor of NF-kappaB, reduced the TPA-induced expression of COX-2 and MMP-9.	Tetradecanoylphorbol Acetate	129-132	prostaglandin-endoperoxide synthase 2	Homo sapiens	155-160
16380122-12	2006	In summary, hirsutenone inhibits the TPA-induced upregulation of COX-2 and MMP-9 in human breast epithelial cells, possibly by targeting NF-kappaB, which may contribute to its chemopreventive effects.	Tetradecanoylphorbol Acetate	37-40	prostaglandin-endoperoxide synthase 2	Homo sapiens	65-70
16380122-12	2006	In summary, hirsutenone inhibits the TPA-induced upregulation of COX-2 and MMP-9 in human breast epithelial cells, possibly by targeting NF-kappaB, which may contribute to its chemopreventive effects.	Tetradecanoylphorbol Acetate	37-40	nuclear factor kappa B subunit 1	Homo sapiens	137-146
16393992-6	2006	Low concentrations of PMA or arachidonic acid (known activators of NADPH oxidase) or xanthine/xanthine oxidase or glucose oxidase (generating hydrogen peroxide) also increased microglia proliferation and this was blocked by catalase, showing that NADPH oxidase activation or hydrogen peroxide was sufficient to stimulate microglia proliferation.	Tetradecanoylphorbol Acetate	22-25	catalase	Rattus norvegicus	224-232
16143405-7	2006	Upon activation with PMA and ionomycin, the purified CD4+CCR4+ T lymphocytes produced IL-4 and no IFN-gamma.	Tetradecanoylphorbol Acetate	21-24	CD4 molecule	Homo sapiens	53-56
16143405-7	2006	Upon activation with PMA and ionomycin, the purified CD4+CCR4+ T lymphocytes produced IL-4 and no IFN-gamma.	Tetradecanoylphorbol Acetate	21-24	interleukin 4	Homo sapiens	86-90
16374540-2	2006	Safingol inhibited the translocation of PKC following treatment with 12-o-tetradecanoylphorbol 13-acetate (TPA) in PKC alpha-EGFP-transfected cells, but not in PKC beta-EGFP- transfected cells, indicating selective inhibition for PKC alpha in oral SCC cells.	Tetradecanoylphorbol Acetate	69-105	protein kinase C alpha	Homo sapiens	40-43
16424044-8	2006	The antiproliferative effect of the indolamine on these cells is partially abolished when coincubated with the PKC activator 12-O-tetradecanoylphorbol-13-acetate, thus indicating that the ability of melatonin to change cellular redox state may be inactivating the pathway RTK/PKC/Akt/NF-kappaB.	Tetradecanoylphorbol Acetate	125-161	ret proto-oncogene	Rattus norvegicus	272-275
16424044-8	2006	The antiproliferative effect of the indolamine on these cells is partially abolished when coincubated with the PKC activator 12-O-tetradecanoylphorbol-13-acetate, thus indicating that the ability of melatonin to change cellular redox state may be inactivating the pathway RTK/PKC/Akt/NF-kappaB.	Tetradecanoylphorbol Acetate	125-161	AKT serine/threonine kinase 1	Rattus norvegicus	280-283
16424000-7	2006	The proapoptotic activity of PKCdelta coupled with its ability to suppress TPA-induced expression of proinflammatory cytokines, COX-2 expression, and the phosphorylation of Akt and p38 may play roles in the suppression of TPA-promoted development of SCC.	Tetradecanoylphorbol Acetate	75-78	thymoma viral proto-oncogene 1	Mus musculus	173-176
16424000-7	2006	The proapoptotic activity of PKCdelta coupled with its ability to suppress TPA-induced expression of proinflammatory cytokines, COX-2 expression, and the phosphorylation of Akt and p38 may play roles in the suppression of TPA-promoted development of SCC.	Tetradecanoylphorbol Acetate	222-225	thymoma viral proto-oncogene 1	Mus musculus	173-176
16263294-2	2006	Many showed inhibition of TNF-alpha production in response to the tumor promotor TPA on HL-60 cells.	Tetradecanoylphorbol Acetate	81-84	tumor necrosis factor	Homo sapiens	26-35
16374540-2	2006	Safingol inhibited the translocation of PKC following treatment with 12-o-tetradecanoylphorbol 13-acetate (TPA) in PKC alpha-EGFP-transfected cells, but not in PKC beta-EGFP- transfected cells, indicating selective inhibition for PKC alpha in oral SCC cells.	Tetradecanoylphorbol Acetate	69-105	protein kinase C alpha	Homo sapiens	115-124
16374540-2	2006	Safingol inhibited the translocation of PKC following treatment with 12-o-tetradecanoylphorbol 13-acetate (TPA) in PKC alpha-EGFP-transfected cells, but not in PKC beta-EGFP- transfected cells, indicating selective inhibition for PKC alpha in oral SCC cells.	Tetradecanoylphorbol Acetate	107-110	protein kinase C alpha	Homo sapiens	40-43
16374540-2	2006	Safingol inhibited the translocation of PKC following treatment with 12-o-tetradecanoylphorbol 13-acetate (TPA) in PKC alpha-EGFP-transfected cells, but not in PKC beta-EGFP- transfected cells, indicating selective inhibition for PKC alpha in oral SCC cells.	Tetradecanoylphorbol Acetate	107-110	protein kinase C alpha	Homo sapiens	115-124
17193924-5	2006	Furthermore, upregulation of three candidate genes (NFIL3, SKIL, and JMJD3) was shown to be dosage and time dependent with TPA treatment and was found to be directly regulated by TPA through PKC-dependent signaling.	Tetradecanoylphorbol Acetate	123-126	nuclear factor, interleukin 3 regulated	Homo sapiens	52-57
16557002-9	2006	Moreover, we found that the cytoplasmic domain of another EGFR ligand, transforming growth factor-alpha, is phosphorylated upon TPA stimulation.	Tetradecanoylphorbol Acetate	128-131	tumor necrosis factor	Homo sapiens	71-103
19771276-10	2006	Moreover, celecoxib suppressed the TPA-induced nuclear expression of C/EBPdelta, but not C/EBPbeta, in mouse skin in vivo.	Tetradecanoylphorbol Acetate	35-38	CCAAT/enhancer binding protein (C/EBP), delta	Mus musculus	69-79
17193924-5	2006	Furthermore, upregulation of three candidate genes (NFIL3, SKIL, and JMJD3) was shown to be dosage and time dependent with TPA treatment and was found to be directly regulated by TPA through PKC-dependent signaling.	Tetradecanoylphorbol Acetate	179-182	nuclear factor, interleukin 3 regulated	Homo sapiens	52-57
16423038-7	2006	Promoter deletion analysis localized a phorbol 12-myristate 13-acetate (PMA)-sensitive element to a proximal promoter region between -109 and -79 base pairs upstream from the IL-13 transcription start site.	Tetradecanoylphorbol Acetate	39-70	interleukin 13	Mus musculus	175-180
16716806-0	2006	Se-methylselenocysteine enhances PMA-mediated CD11c expression via phospholipase D1 activation in U937 cells.	Tetradecanoylphorbol Acetate	33-36	phospholipase D1	Homo sapiens	67-83
16423038-7	2006	Promoter deletion analysis localized a phorbol 12-myristate 13-acetate (PMA)-sensitive element to a proximal promoter region between -109 and -79 base pairs upstream from the IL-13 transcription start site.	Tetradecanoylphorbol Acetate	72-75	interleukin 13	Mus musculus	175-180
17329956-4	2006	Induction of cyclin D1 expression in TPA-treated HL60 cells was inhibited with protein kinase C (PKC) inhibitor bisindolylmaleimide I and mitogen activated protein kinase kinase (MEK) inhibitor PD98059.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase kinase 7	Homo sapiens	179-182
16365438-3	2006	To further analyze the molecular mechanism by which the viral gene controls TNF-alpha, we have used Jurkat cells stably transfected with the viral gene to identify the TNF-alpha regulatory elements involved in the induction of the gene after stimulation with PMA and calcium ionophore.	Tetradecanoylphorbol Acetate	259-262	tumor necrosis factor	Homo sapiens	168-177
16997790-0	2006	PMA and doxorubicin decrease viability, MTT activity and expression of CD10 marker on NALM-1 leukemic cells.	Tetradecanoylphorbol Acetate	0-3	membrane metalloendopeptidase	Homo sapiens	71-75
16997791-7	2006	Furthermore, AIAE attenuated the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 secretion in human mast cells.	Tetradecanoylphorbol Acetate	33-64	interleukin 6	Homo sapiens	138-151
16357489-12	2006	In addition, DAAE decreased TNF-alpha and IL-6 gene expression and production in human mast cells stimulated by phorbol-12-myristate-13-acetate (PMA) plus calcium ionophore A23187.	Tetradecanoylphorbol Acetate	112-143	tumor necrosis factor	Homo sapiens	28-37
16357489-12	2006	In addition, DAAE decreased TNF-alpha and IL-6 gene expression and production in human mast cells stimulated by phorbol-12-myristate-13-acetate (PMA) plus calcium ionophore A23187.	Tetradecanoylphorbol Acetate	112-143	interleukin 6	Homo sapiens	42-46
16357489-12	2006	In addition, DAAE decreased TNF-alpha and IL-6 gene expression and production in human mast cells stimulated by phorbol-12-myristate-13-acetate (PMA) plus calcium ionophore A23187.	Tetradecanoylphorbol Acetate	145-148	tumor necrosis factor	Homo sapiens	28-37
16357489-12	2006	In addition, DAAE decreased TNF-alpha and IL-6 gene expression and production in human mast cells stimulated by phorbol-12-myristate-13-acetate (PMA) plus calcium ionophore A23187.	Tetradecanoylphorbol Acetate	145-148	interleukin 6	Homo sapiens	42-46
16417217-2	2006	Glis1 mRNA is not expressed in normal human epidermis, but is significantly induced in psoriatic epidermis and in mouse skin upon treatment with the tumor promoter phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	164-195	GLIS family zinc finger 1	Homo sapiens	0-5
16417217-2	2006	Glis1 mRNA is not expressed in normal human epidermis, but is significantly induced in psoriatic epidermis and in mouse skin upon treatment with the tumor promoter phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	197-200	GLIS family zinc finger 1	Homo sapiens	0-5
16417217-6	2006	A similar induction of Glis1 mRNA by PMA treatment was observed in the immortalized epidermal keratinocyte cell line NHEK-HPV, whereas PMA did not induce Glis1 in HaCaT cells or in several squamous cell carcinoma cell lines.	Tetradecanoylphorbol Acetate	37-40	GLIS family zinc finger 1	Homo sapiens	23-28
17329956-0	2006	PKC pathway and ERK/MAPK pathway are required for induction of cyclin D1 and p21Waf1 during 12-o-tetradecanoylphorbol 13-acetate-induced differentiation of myeloleukemia cells.	Tetradecanoylphorbol Acetate	92-128	proline rich transmembrane protein 2	Homo sapiens	0-3
17329956-0	2006	PKC pathway and ERK/MAPK pathway are required for induction of cyclin D1 and p21Waf1 during 12-o-tetradecanoylphorbol 13-acetate-induced differentiation of myeloleukemia cells.	Tetradecanoylphorbol Acetate	92-128	mitogen-activated protein kinase 1	Homo sapiens	16-19
17329956-0	2006	PKC pathway and ERK/MAPK pathway are required for induction of cyclin D1 and p21Waf1 during 12-o-tetradecanoylphorbol 13-acetate-induced differentiation of myeloleukemia cells.	Tetradecanoylphorbol Acetate	92-128	mitogen-activated protein kinase 1	Homo sapiens	20-24
17329956-5	2006	Induction of p21Waf1 expression in TPA-treated HL60 cells was inhibited with PKC inhibitor bisindolylmaleimide I and Go6976, MEK inhibitor PD98059, and p38 mitogen-actibated protein kinase (MAPK) inhibitor SB202190.	Tetradecanoylphorbol Acetate	35-38	proline rich transmembrane protein 2	Homo sapiens	77-80
17329956-5	2006	Induction of p21Waf1 expression in TPA-treated HL60 cells was inhibited with PKC inhibitor bisindolylmaleimide I and Go6976, MEK inhibitor PD98059, and p38 mitogen-actibated protein kinase (MAPK) inhibitor SB202190.	Tetradecanoylphorbol Acetate	35-38	mitogen-activated protein kinase kinase 7	Homo sapiens	125-128
17329956-4	2006	Induction of cyclin D1 expression in TPA-treated HL60 cells was inhibited with protein kinase C (PKC) inhibitor bisindolylmaleimide I and mitogen activated protein kinase kinase (MEK) inhibitor PD98059.	Tetradecanoylphorbol Acetate	37-40	proline rich transmembrane protein 2	Homo sapiens	79-95
17329956-4	2006	Induction of cyclin D1 expression in TPA-treated HL60 cells was inhibited with protein kinase C (PKC) inhibitor bisindolylmaleimide I and mitogen activated protein kinase kinase (MEK) inhibitor PD98059.	Tetradecanoylphorbol Acetate	37-40	proline rich transmembrane protein 2	Homo sapiens	97-100
17329956-5	2006	Induction of p21Waf1 expression in TPA-treated HL60 cells was inhibited with PKC inhibitor bisindolylmaleimide I and Go6976, MEK inhibitor PD98059, and p38 mitogen-actibated protein kinase (MAPK) inhibitor SB202190.	Tetradecanoylphorbol Acetate	35-38	mitogen-activated protein kinase 1	Homo sapiens	190-194
17329956-4	2006	Induction of cyclin D1 expression in TPA-treated HL60 cells was inhibited with protein kinase C (PKC) inhibitor bisindolylmaleimide I and mitogen activated protein kinase kinase (MEK) inhibitor PD98059.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase kinase 7	Homo sapiens	138-177
17329956-6	2006	Thus, cyclin D1 and p21Waf1 expressions are considered to be induced via PKC and extracellular signal-regulated kinase/mitogen-activated protein kinase (MAPK/ERK) pathways in TPA-treated HL60 cells.	Tetradecanoylphorbol Acetate	175-178	proline rich transmembrane protein 2	Homo sapiens	73-76
17329956-6	2006	Thus, cyclin D1 and p21Waf1 expressions are considered to be induced via PKC and extracellular signal-regulated kinase/mitogen-activated protein kinase (MAPK/ERK) pathways in TPA-treated HL60 cells.	Tetradecanoylphorbol Acetate	175-178	mitogen-activated protein kinase 1	Homo sapiens	153-157
17329956-6	2006	Thus, cyclin D1 and p21Waf1 expressions are considered to be induced via PKC and extracellular signal-regulated kinase/mitogen-activated protein kinase (MAPK/ERK) pathways in TPA-treated HL60 cells.	Tetradecanoylphorbol Acetate	175-178	mitogen-activated protein kinase 1	Homo sapiens	158-161
16267831-5	2006	The 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of ERK1/2 through the phosphorylation of threonine and tyrosine at 202 and 204, respectively, was demonstrated in both cell lines, however, in a discrete manner.	Tetradecanoylphorbol Acetate	4-40	mitogen-activated protein kinase 3	Homo sapiens	69-75
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	20-45	CD93 molecule	Homo sapiens	75-79
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	20-45	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	20-45	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	20-45	interferon gamma	Homo sapiens	201-217
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	20-45	interferon gamma	Homo sapiens	219-228
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	47-50	CD93 molecule	Homo sapiens	75-79
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	147-160
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	47-50	interferon gamma	Homo sapiens	201-217
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	47-50	interferon gamma	Homo sapiens	219-228
16267831-6	2006	TPA-induced activation of ERK1/2 was sustained in wild-type p53 cells, while only a transient activation was seen in mutant p53 cells.	Tetradecanoylphorbol Acetate	0-3	tumor protein p53	Homo sapiens	124-127
16267831-7	2006	Inhibition of MAPK kinase (MEK), an upstream kinase, by U0126, blocked TPA-induced activation of ERK1/2 in wild-type p53 cells and in mutant p53 cells.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase kinase 7	Homo sapiens	27-30
16267831-7	2006	Inhibition of MAPK kinase (MEK), an upstream kinase, by U0126, blocked TPA-induced activation of ERK1/2 in wild-type p53 cells and in mutant p53 cells.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase 3	Homo sapiens	97-103
16267831-7	2006	Inhibition of MAPK kinase (MEK), an upstream kinase, by U0126, blocked TPA-induced activation of ERK1/2 in wild-type p53 cells and in mutant p53 cells.	Tetradecanoylphorbol Acetate	71-74	tumor protein p53	Homo sapiens	117-120
16267831-5	2006	The 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of ERK1/2 through the phosphorylation of threonine and tyrosine at 202 and 204, respectively, was demonstrated in both cell lines, however, in a discrete manner.	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 3	Homo sapiens	69-75
16267831-6	2006	TPA-induced activation of ERK1/2 was sustained in wild-type p53 cells, while only a transient activation was seen in mutant p53 cells.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	26-32
16267831-6	2006	TPA-induced activation of ERK1/2 was sustained in wild-type p53 cells, while only a transient activation was seen in mutant p53 cells.	Tetradecanoylphorbol Acetate	0-3	tumor protein p53	Homo sapiens	60-63
16267831-7	2006	Inhibition of MAPK kinase (MEK), an upstream kinase, by U0126, blocked TPA-induced activation of ERK1/2 in wild-type p53 cells and in mutant p53 cells.	Tetradecanoylphorbol Acetate	71-74	tumor protein p53	Homo sapiens	141-144
16267831-8	2006	Treatment of wild-type p53 (SK-Mel 186) cells with small interfering RNA (siRNA) of p53 displayed a transient induction of activation of ERK1/2 following TPA treatment, indicating that p53 has a role in the regulation of the activation of ERK1/2.	Tetradecanoylphorbol Acetate	154-157	tumor protein p53	Homo sapiens	23-26
17152808-6	2006	Blood sample was obtained from patients and examined for the expression of Interleukin 2, 4, and 13 and IFN-gamma by intracellular staining procedure after stimulation with PMA/ionomycin (phorbol 12-myristate 13-acetate) and allergen (D. pteronyssimus, Allergopharma).	Tetradecanoylphorbol Acetate	173-176	interferon gamma	Homo sapiens	104-113
16267831-8	2006	Treatment of wild-type p53 (SK-Mel 186) cells with small interfering RNA (siRNA) of p53 displayed a transient induction of activation of ERK1/2 following TPA treatment, indicating that p53 has a role in the regulation of the activation of ERK1/2.	Tetradecanoylphorbol Acetate	154-157	tumor protein p53	Homo sapiens	84-87
16267831-8	2006	Treatment of wild-type p53 (SK-Mel 186) cells with small interfering RNA (siRNA) of p53 displayed a transient induction of activation of ERK1/2 following TPA treatment, indicating that p53 has a role in the regulation of the activation of ERK1/2.	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase 3	Homo sapiens	137-143
16267831-8	2006	Treatment of wild-type p53 (SK-Mel 186) cells with small interfering RNA (siRNA) of p53 displayed a transient induction of activation of ERK1/2 following TPA treatment, indicating that p53 has a role in the regulation of the activation of ERK1/2.	Tetradecanoylphorbol Acetate	154-157	tumor protein p53	Homo sapiens	84-87
16267831-8	2006	Treatment of wild-type p53 (SK-Mel 186) cells with small interfering RNA (siRNA) of p53 displayed a transient induction of activation of ERK1/2 following TPA treatment, indicating that p53 has a role in the regulation of the activation of ERK1/2.	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase 3	Homo sapiens	239-245
16267831-10	2006	The expression of either wild-type or mutant p53 had a similar effect on TPA-induced Jun N-terminal kinase (JNK) activation, indicating specificity for the ERK pathway.	Tetradecanoylphorbol Acetate	73-76	tumor protein p53	Homo sapiens	45-48
16267831-10	2006	The expression of either wild-type or mutant p53 had a similar effect on TPA-induced Jun N-terminal kinase (JNK) activation, indicating specificity for the ERK pathway.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase 8	Homo sapiens	85-106
16267831-10	2006	The expression of either wild-type or mutant p53 had a similar effect on TPA-induced Jun N-terminal kinase (JNK) activation, indicating specificity for the ERK pathway.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase 8	Homo sapiens	108-111
16267831-10	2006	The expression of either wild-type or mutant p53 had a similar effect on TPA-induced Jun N-terminal kinase (JNK) activation, indicating specificity for the ERK pathway.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase 1	Homo sapiens	156-159
16267831-11	2006	Similarly, AP-1 binding activity showed a transient variation in both cell lines after TPA treatment but with different kinetics.	Tetradecanoylphorbol Acetate	87-90	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	11-15
16877877-11	2006	Thrombin activatable fibrinolysis inhibitor is a carboxypeptidase that cleaves the carboxylic lysine residues on fibrin, thereby abolishing the critical binding site for tPA-plasminogen decreasing plasmin formation.	Tetradecanoylphorbol Acetate	170-173	coagulation factor II, thrombin	Homo sapiens	0-8
17152808-6	2006	Blood sample was obtained from patients and examined for the expression of Interleukin 2, 4, and 13 and IFN-gamma by intracellular staining procedure after stimulation with PMA/ionomycin (phorbol 12-myristate 13-acetate) and allergen (D. pteronyssimus, Allergopharma).	Tetradecanoylphorbol Acetate	188-219	interferon gamma	Homo sapiens	104-113
17152808-7	2006	Negative correlation was found between expression of Interleukin 2, 4, 13 after PMA/ionomycin and allergen stimulation (p &gt; 0.05) into two groups.	Tetradecanoylphorbol Acetate	80-83	interleukin 2	Homo sapiens	53-66
16351709-4	2005	We have previously demonstrated that the embryonal rhabdomyosarcoma cell line undergoes growth arrest and myogenic differentiation following treatments with TPA and the MEK inhibitor U0126, which respectively activate and inhibit the ERK pathway.	Tetradecanoylphorbol Acetate	157-160	mitogen-activated protein kinase 1	Homo sapiens	234-237
15936049-10	2005	Furthermore, LAE decreased the secretion of TNF-alpha and IL-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells.	Tetradecanoylphorbol Acetate	66-97	tumor necrosis factor	Homo sapiens	44-53
15936049-10	2005	Furthermore, LAE decreased the secretion of TNF-alpha and IL-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells.	Tetradecanoylphorbol Acetate	66-97	interleukin 6	Homo sapiens	58-62
15936049-10	2005	Furthermore, LAE decreased the secretion of TNF-alpha and IL-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells.	Tetradecanoylphorbol Acetate	99-102	tumor necrosis factor	Homo sapiens	44-53
15936049-10	2005	Furthermore, LAE decreased the secretion of TNF-alpha and IL-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells.	Tetradecanoylphorbol Acetate	99-102	interleukin 6	Homo sapiens	58-62
16319225-5	2005	In primary CD8(+) T cells, which express only TR2 and TR4 and are resistant to TRAIL-induced apoptosis, stimulation with phorbol myristate acetate abrogated the ligand-independent interaction between TR2 and TR4 and enhanced their sensitivity to TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	121-146	TNF superfamily member 10	Homo sapiens	79-84
16319225-5	2005	In primary CD8(+) T cells, which express only TR2 and TR4 and are resistant to TRAIL-induced apoptosis, stimulation with phorbol myristate acetate abrogated the ligand-independent interaction between TR2 and TR4 and enhanced their sensitivity to TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	121-146	TNF superfamily member 10	Homo sapiens	246-251
16351709-7	2005	Furthermore, the TPA-mediated post-transcriptional mechanism of p21WAF1-enhanced expression in RD cells is due to activation of the MEK/ERK pathway, as shown by transfections with constitutively active MEK1 or MEK2, which induces p21WAF1 expression, and with ERK1 and ERK2 siRNA, which prevents p21WAF1 expression.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase kinase 7	Homo sapiens	132-135
16351709-7	2005	Furthermore, the TPA-mediated post-transcriptional mechanism of p21WAF1-enhanced expression in RD cells is due to activation of the MEK/ERK pathway, as shown by transfections with constitutively active MEK1 or MEK2, which induces p21WAF1 expression, and with ERK1 and ERK2 siRNA, which prevents p21WAF1 expression.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase 1	Homo sapiens	136-139
16351709-7	2005	Furthermore, the TPA-mediated post-transcriptional mechanism of p21WAF1-enhanced expression in RD cells is due to activation of the MEK/ERK pathway, as shown by transfections with constitutively active MEK1 or MEK2, which induces p21WAF1 expression, and with ERK1 and ERK2 siRNA, which prevents p21WAF1 expression.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase 3	Homo sapiens	259-263
16351709-7	2005	Furthermore, the TPA-mediated post-transcriptional mechanism of p21WAF1-enhanced expression in RD cells is due to activation of the MEK/ERK pathway, as shown by transfections with constitutively active MEK1 or MEK2, which induces p21WAF1 expression, and with ERK1 and ERK2 siRNA, which prevents p21WAF1 expression.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase 1	Homo sapiens	268-272
16351709-9	2005	Similarly, myogenin and MyoD expression is induced both by U0126 and TPA and is prevented by p38 inhibition.	Tetradecanoylphorbol Acetate	69-72	myogenic differentiation 1	Homo sapiens	24-28
16275618-7	2005	Furthermore, GRJ decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated TNF-alpha and IL-6 secretion in human mast cells.	Tetradecanoylphorbol Acetate	31-62	tumor necrosis factor	Homo sapiens	104-113
16339753-4	2005	Flow cytometry analysis of CD61 indicated that phorbol myristate acetate (PMA) (16 nM) stimulated megakaryocytic commitment of K562 cells was increased (3- to 4-fold) following exposure to Tat (1-100 ng/ml).	Tetradecanoylphorbol Acetate	47-72	integrin subunit beta 3	Homo sapiens	27-31
16339753-4	2005	Flow cytometry analysis of CD61 indicated that phorbol myristate acetate (PMA) (16 nM) stimulated megakaryocytic commitment of K562 cells was increased (3- to 4-fold) following exposure to Tat (1-100 ng/ml).	Tetradecanoylphorbol Acetate	74-77	integrin subunit beta 3	Homo sapiens	27-31
16275618-7	2005	Furthermore, GRJ decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated TNF-alpha and IL-6 secretion in human mast cells.	Tetradecanoylphorbol Acetate	31-62	interleukin 6	Homo sapiens	118-122
16271356-6	2005	Exposure to PMA for 1-2 days additionally induced down-regulation of claudin-2 and up-regulation of barrier modulating matrix metalloproteinase (MMP)-9, respectively.	Tetradecanoylphorbol Acetate	12-15	claudin 2	Homo sapiens	69-78
16313517-0	2005	Opposing effects of phorbol-12-myristate-13-acetate, an activator of protein kinase C, on the signaling of structurally related human dopamine D1 and D5 receptors.	Tetradecanoylphorbol Acetate	20-51	dopamine receptor D1	Homo sapiens	134-162
16153182-0	2005	Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428.	Tetradecanoylphorbol Acetate	61-64	phosphodiesterase 3A	Homo sapiens	0-20
16183650-4	2005	The apoptotic effect of phorbol 12-myristate 13-acetate in LNCaP cells was impaired by inhibition or depletion of tumor necrosis factor alpha-converting enzyme, the enzyme responsible for tumor necrosis factor alpha (TNFalpha) shedding.	Tetradecanoylphorbol Acetate	24-55	tumor necrosis factor	Homo sapiens	114-141
16183650-4	2005	The apoptotic effect of phorbol 12-myristate 13-acetate in LNCaP cells was impaired by inhibition or depletion of tumor necrosis factor alpha-converting enzyme, the enzyme responsible for tumor necrosis factor alpha (TNFalpha) shedding.	Tetradecanoylphorbol Acetate	24-55	tumor necrosis factor	Homo sapiens	217-225
16183650-5	2005	Moreover, the apoptogenic effect of conditioned medium collected after phorbol 12-myristate 13-acetate treatment could be inhibited by blocking antibodies against TNFalpha and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), but not FasL, as well as by RNA interference depletion of TNFalpha and TRAIL receptors.	Tetradecanoylphorbol Acetate	71-102	tumor necrosis factor	Homo sapiens	163-171
16183650-5	2005	Moreover, the apoptogenic effect of conditioned medium collected after phorbol 12-myristate 13-acetate treatment could be inhibited by blocking antibodies against TNFalpha and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), but not FasL, as well as by RNA interference depletion of TNFalpha and TRAIL receptors.	Tetradecanoylphorbol Acetate	71-102	TNF superfamily member 10	Homo sapiens	176-231
16183650-5	2005	Moreover, the apoptogenic effect of conditioned medium collected after phorbol 12-myristate 13-acetate treatment could be inhibited by blocking antibodies against TNFalpha and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), but not FasL, as well as by RNA interference depletion of TNFalpha and TRAIL receptors.	Tetradecanoylphorbol Acetate	71-102	tumor necrosis factor	Homo sapiens	299-307
16183650-5	2005	Moreover, the apoptogenic effect of conditioned medium collected after phorbol 12-myristate 13-acetate treatment could be inhibited by blocking antibodies against TNFalpha and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), but not FasL, as well as by RNA interference depletion of TNFalpha and TRAIL receptors.	Tetradecanoylphorbol Acetate	71-102	TNF superfamily member 10	Homo sapiens	312-317
16153182-6	2005	Using MS/MS of IMAC (immobilized metal ion affinity chromatography)-enriched tryptic phosphopeptides and phosphospecific antibodies, at least five sites on PDE3A were found to be phosphorylated in vivo, of which Ser428 was selectively phosphorylated in response to PMA and dephosphorylated in cells treated with aphidicolin and mimosine.	Tetradecanoylphorbol Acetate	265-268	phosphodiesterase 3A	Homo sapiens	156-161
16179364-4	2005	When we applied phorbol 12-myristate 13-acetate (PMA), a potent PKC activator, we observed a large positive shift (17.8 +/- 1.6 mV) in the G-V curve for KCNQ2, while chelerythrine, a PKC inhibitor, attenuated the shift caused by the stimulation of M1 receptors.	Tetradecanoylphorbol Acetate	16-47	proline rich transmembrane protein 2	Homo sapiens	64-67
16179364-4	2005	When we applied phorbol 12-myristate 13-acetate (PMA), a potent PKC activator, we observed a large positive shift (17.8 +/- 1.6 mV) in the G-V curve for KCNQ2, while chelerythrine, a PKC inhibitor, attenuated the shift caused by the stimulation of M1 receptors.	Tetradecanoylphorbol Acetate	16-47	proline rich transmembrane protein 2	Homo sapiens	183-186
16179364-4	2005	When we applied phorbol 12-myristate 13-acetate (PMA), a potent PKC activator, we observed a large positive shift (17.8 +/- 1.6 mV) in the G-V curve for KCNQ2, while chelerythrine, a PKC inhibitor, attenuated the shift caused by the stimulation of M1 receptors.	Tetradecanoylphorbol Acetate	49-52	proline rich transmembrane protein 2	Homo sapiens	64-67
16179364-4	2005	When we applied phorbol 12-myristate 13-acetate (PMA), a potent PKC activator, we observed a large positive shift (17.8 +/- 1.6 mV) in the G-V curve for KCNQ2, while chelerythrine, a PKC inhibitor, attenuated the shift caused by the stimulation of M1 receptors.	Tetradecanoylphorbol Acetate	49-52	proline rich transmembrane protein 2	Homo sapiens	183-186
16225758-7	2005	SM735 dose-dependently inhibited proinflammatory cytokine production [including interleukins (IL)-12, interferon (IFN)-gamma and IL-6] induced by LPS or PMA plus ionomycin.	Tetradecanoylphorbol Acetate	153-156	interleukin 6	Mus musculus	129-133
16272292-6	2005	In contrast, PMA induces cyclin T1 protein up-regulation by stabilizing cyclin T1 protein, apparently independently of the proteasome and without accumulation of cyclin T1 mRNA.	Tetradecanoylphorbol Acetate	13-16	cyclin T1	Homo sapiens	25-34
16150861-8	2005	In the same concentration range, the compounds inhibited TNF-alpha release from PMA-induced OM-10.1 cells but allowed TNF-alpha production from PMA-induced U1 cells at all concentrations tested.	Tetradecanoylphorbol Acetate	80-83	tumor necrosis factor	Homo sapiens	57-66
16000638-6	2005	PMA-induced internalization of NKCC1 is dependent on the epsilon-isoform of PKC as determined on the basis of sensitivity to a panel of PKC inhibitors.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	76-79
16000638-6	2005	PMA-induced internalization of NKCC1 is dependent on the epsilon-isoform of PKC as determined on the basis of sensitivity to a panel of PKC inhibitors.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	136-139
16356124-2	2005	In the present study, we investigated the possible inhibitory effects of curcumin on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in MCF10A human breast epithelial (MCF10A) cells and the underlying mechanisms.	Tetradecanoylphorbol Acetate	149-185	prostaglandin-endoperoxide synthase 2	Homo sapiens	103-108
16356124-2	2005	In the present study, we investigated the possible inhibitory effects of curcumin on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in MCF10A human breast epithelial (MCF10A) cells and the underlying mechanisms.	Tetradecanoylphorbol Acetate	187-190	prostaglandin-endoperoxide synthase 2	Homo sapiens	103-108
16356124-3	2005	Curcumin inhibited the TPA-induced COX-2 expression at both transcriptional and post-transcriptional levels, and reduced the synthesis of prostaglandin E(2), one of the major products of COX-2.	Tetradecanoylphorbol Acetate	23-26	prostaglandin-endoperoxide synthase 2	Homo sapiens	35-40
16356124-3	2005	Curcumin inhibited the TPA-induced COX-2 expression at both transcriptional and post-transcriptional levels, and reduced the synthesis of prostaglandin E(2), one of the major products of COX-2.	Tetradecanoylphorbol Acetate	23-26	prostaglandin-endoperoxide synthase 2	Homo sapiens	187-192
16356124-5	2005	Curcumin blocked TPA-induced activation of extracellular signal-regulated protein kinase (ERK1/2) and nuclear factor kappaB (NF-kappaB) transcriptional activity.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase 3	Homo sapiens	90-96
16356124-5	2005	Curcumin blocked TPA-induced activation of extracellular signal-regulated protein kinase (ERK1/2) and nuclear factor kappaB (NF-kappaB) transcriptional activity.	Tetradecanoylphorbol Acetate	17-20	nuclear factor kappa B subunit 1	Homo sapiens	117-123
16356124-5	2005	Curcumin blocked TPA-induced activation of extracellular signal-regulated protein kinase (ERK1/2) and nuclear factor kappaB (NF-kappaB) transcriptional activity.	Tetradecanoylphorbol Acetate	17-20	nuclear factor kappa B subunit 1	Homo sapiens	125-134
16356124-6	2005	Overexpression of the dominant negative forms of ERK2 abrogated the TPA-induced NF-kappaB transcriptional activity.	Tetradecanoylphorbol Acetate	68-71	mitogen-activated protein kinase 1	Homo sapiens	49-53
16356124-6	2005	Overexpression of the dominant negative forms of ERK2 abrogated the TPA-induced NF-kappaB transcriptional activity.	Tetradecanoylphorbol Acetate	68-71	nuclear factor kappa B subunit 1	Homo sapiens	80-89
16356124-7	2005	Treatment of MCF10A cells with U0126, which is a pharmacological inhibitor of ERK1/2, reduced TPA-induced up-regulation of COX-2 and MMP-9.	Tetradecanoylphorbol Acetate	94-97	mitogen-activated protein kinase 3	Homo sapiens	78-84
16356124-7	2005	Treatment of MCF10A cells with U0126, which is a pharmacological inhibitor of ERK1/2, reduced TPA-induced up-regulation of COX-2 and MMP-9.	Tetradecanoylphorbol Acetate	94-97	prostaglandin-endoperoxide synthase 2	Homo sapiens	123-128
16356124-8	2005	Taken together, these findings suggest that curcumin inhibits the TPA-induced up-regulation of COX-2 and MMP-9 by suppressing ERK1/2 phosphorylation and NF-kappaB trans-activation in human breast epithelial cells, which may contribute to its chemopreventive potential.	Tetradecanoylphorbol Acetate	66-69	prostaglandin-endoperoxide synthase 2	Homo sapiens	95-100
16356124-8	2005	Taken together, these findings suggest that curcumin inhibits the TPA-induced up-regulation of COX-2 and MMP-9 by suppressing ERK1/2 phosphorylation and NF-kappaB trans-activation in human breast epithelial cells, which may contribute to its chemopreventive potential.	Tetradecanoylphorbol Acetate	66-69	mitogen-activated protein kinase 3	Homo sapiens	126-132
16356124-8	2005	Taken together, these findings suggest that curcumin inhibits the TPA-induced up-regulation of COX-2 and MMP-9 by suppressing ERK1/2 phosphorylation and NF-kappaB trans-activation in human breast epithelial cells, which may contribute to its chemopreventive potential.	Tetradecanoylphorbol Acetate	66-69	nuclear factor kappa B subunit 1	Homo sapiens	153-162
15985361-6	2005	Nevertheless, PMA stimulated translocation of PKC-alpha, -betaI, -betaII, and -gamma, but only anti-PKC-gamma co-immunoprecipitated the receptors.	Tetradecanoylphorbol Acetate	14-17	protein kinase C alpha	Homo sapiens	46-55
16305951-2	2005	METHODS: KBV200 cells were preincubated with PKC activator phorbol-12-myristate-13-acetate (PMA, 200 nmol/L) and PKC activity was assayed by measurement of peptide substrate (32)P incorporation from [gamma-(32)P]ATP, with the cells without PMA preincubation serving as the control.	Tetradecanoylphorbol Acetate	59-90	protein kinase C alpha	Homo sapiens	45-48
16305951-4	2005	RESULTS: PMA preincubation of the cells significantly enhanced the activity of the total PKC and the membrane fraction, but lowered the PKC activity of the cytosol fraction, as compared with the cells without PMA treatment (P&lt;0.01).	Tetradecanoylphorbol Acetate	9-12	protein kinase C alpha	Homo sapiens	89-92
16305951-4	2005	RESULTS: PMA preincubation of the cells significantly enhanced the activity of the total PKC and the membrane fraction, but lowered the PKC activity of the cytosol fraction, as compared with the cells without PMA treatment (P&lt;0.01).	Tetradecanoylphorbol Acetate	9-12	protein kinase C alpha	Homo sapiens	136-139
15936242-0	2005	Involvement of nuclear factor kappaB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells.	Tetradecanoylphorbol Acetate	93-129	aldo-keto reductase family 1 member B	Homo sapiens	57-73
15936242-1	2005	To elucidate the molecular mechanisms underlying the up-regulation of aldose reductase observed in many cancer cells, we investigated the signal transduction pathways mediating induction of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate, a potent tumor promoter.	Tetradecanoylphorbol Acetate	226-262	aldo-keto reductase family 1 member B	Homo sapiens	70-86
15936242-1	2005	To elucidate the molecular mechanisms underlying the up-regulation of aldose reductase observed in many cancer cells, we investigated the signal transduction pathways mediating induction of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate, a potent tumor promoter.	Tetradecanoylphorbol Acetate	226-262	aldo-keto reductase family 1 member B	Homo sapiens	190-206
15936242-2	2005	A maximum of four-fold induction in aldose reductase mRNA was demonstrated in HeLa cells treated with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	102-138	aldo-keto reductase family 1 member B	Homo sapiens	36-52
15936242-4	2005	Inhibitors of protein kinase C, bisindolylmaleimide I and calphostin C, as well as inhibitors of tyrosine kinase, genistein and tyrphostin A23, significantly attenuated 12-O-tetradecanoylphorbol-13-acetate-induced increase in aldose reductase mRNA.	Tetradecanoylphorbol Acetate	169-205	aldo-keto reductase family 1 member B	Homo sapiens	226-242
15936242-5	2005	Blockade of the p38 mitogen-activated protein kinase pathway by SB203580 also suppressed 12-O-tetradecanoylphorbol-13-acetate-induced aldose reductase expression.	Tetradecanoylphorbol Acetate	89-125	mitogen-activated protein kinase 14	Homo sapiens	16-19
15936242-5	2005	Blockade of the p38 mitogen-activated protein kinase pathway by SB203580 also suppressed 12-O-tetradecanoylphorbol-13-acetate-induced aldose reductase expression.	Tetradecanoylphorbol Acetate	89-125	aldo-keto reductase family 1 member B	Homo sapiens	134-150
15936242-6	2005	The promoter activity of aldose reductase gene was significantly augmented in the cells treated with 12-O-tetradecanoylphorbol-13-acetate, but attenuated in the presence of bisindolylmaleimide I, tyrphostin A23 or SB203580.	Tetradecanoylphorbol Acetate	101-137	aldo-keto reductase family 1 member B	Homo sapiens	25-41
15936242-7	2005	Pyrrolidinedithiocarbamate, a nuclear factor kappaB inhibitor, dose-dependently suppressed 12-O-tetradecanoylphorbol-13-acetate-induced increase in aldose reductase mRNA.	Tetradecanoylphorbol Acetate	91-127	aldo-keto reductase family 1 member B	Homo sapiens	148-164
15936242-9	2005	Taken together, activation of protein kinase C and tyrosine kinase by 12-O-tetradecanoylphorbol-13-acetate elicits increased promoter activity of aldose reductase gene via nuclear factor kappaB.	Tetradecanoylphorbol Acetate	70-106	aldo-keto reductase family 1 member B	Homo sapiens	146-162
15936242-10	2005	A p38 mitogen-activated protein kinase pathway, distinct from the tyrosine kinase pathway, may also take part in 12-O-tetradecanoylphorbol-13-acetate-induced increase in aldose reductase gene expression.	Tetradecanoylphorbol Acetate	113-149	mitogen-activated protein kinase 14	Homo sapiens	2-5
15936242-10	2005	A p38 mitogen-activated protein kinase pathway, distinct from the tyrosine kinase pathway, may also take part in 12-O-tetradecanoylphorbol-13-acetate-induced increase in aldose reductase gene expression.	Tetradecanoylphorbol Acetate	113-149	aldo-keto reductase family 1 member B	Homo sapiens	170-186
16149074-8	2005	The pretreatment with SB202190, an inhibitor for p38 mitogen-activated protein kinase pathway (p38-MAPK), but not other signaling inhibitors, reversed the PMA-induced repression.	Tetradecanoylphorbol Acetate	155-158	mitogen-activated protein kinase 14	Homo sapiens	49-85
16149074-8	2005	The pretreatment with SB202190, an inhibitor for p38 mitogen-activated protein kinase pathway (p38-MAPK), but not other signaling inhibitors, reversed the PMA-induced repression.	Tetradecanoylphorbol Acetate	155-158	mitogen-activated protein kinase 14	Homo sapiens	95-103
16125466-3	2005	The proportion of CD4+ and CD8+ T cells that produced IFN-gamma and IL-4 after stimulation with PMA (Phorbol 12-myristate 13-acetate) and ionomycin was significantly reduced in VL patients compared to sub-clinical and asymptomatic infections or healthy controls.	Tetradecanoylphorbol Acetate	96-99	CD4 molecule	Homo sapiens	18-21
16125466-3	2005	The proportion of CD4+ and CD8+ T cells that produced IFN-gamma and IL-4 after stimulation with PMA (Phorbol 12-myristate 13-acetate) and ionomycin was significantly reduced in VL patients compared to sub-clinical and asymptomatic infections or healthy controls.	Tetradecanoylphorbol Acetate	96-99	interferon gamma	Homo sapiens	54-63
16125466-3	2005	The proportion of CD4+ and CD8+ T cells that produced IFN-gamma and IL-4 after stimulation with PMA (Phorbol 12-myristate 13-acetate) and ionomycin was significantly reduced in VL patients compared to sub-clinical and asymptomatic infections or healthy controls.	Tetradecanoylphorbol Acetate	96-99	interleukin 4	Homo sapiens	68-72
16125466-3	2005	The proportion of CD4+ and CD8+ T cells that produced IFN-gamma and IL-4 after stimulation with PMA (Phorbol 12-myristate 13-acetate) and ionomycin was significantly reduced in VL patients compared to sub-clinical and asymptomatic infections or healthy controls.	Tetradecanoylphorbol Acetate	101-132	CD4 molecule	Homo sapiens	18-21
16125466-3	2005	The proportion of CD4+ and CD8+ T cells that produced IFN-gamma and IL-4 after stimulation with PMA (Phorbol 12-myristate 13-acetate) and ionomycin was significantly reduced in VL patients compared to sub-clinical and asymptomatic infections or healthy controls.	Tetradecanoylphorbol Acetate	101-132	interferon gamma	Homo sapiens	54-63
16125466-3	2005	The proportion of CD4+ and CD8+ T cells that produced IFN-gamma and IL-4 after stimulation with PMA (Phorbol 12-myristate 13-acetate) and ionomycin was significantly reduced in VL patients compared to sub-clinical and asymptomatic infections or healthy controls.	Tetradecanoylphorbol Acetate	101-132	interleukin 4	Homo sapiens	68-72
16323285-3	2005	In contrast, TUR transfectants containing a constitutively active poly(ADP-ribose) polymerase-1 (PARP-1) gene fragment in antisense orientation within the pTracer vector (asPARP TUR cells) demonstrated increasing cell attachment and differentiation after TPA treatment.	Tetradecanoylphorbol Acetate	255-258	poly(ADP-ribose) polymerase 1	Homo sapiens	66-95
16323285-3	2005	In contrast, TUR transfectants containing a constitutively active poly(ADP-ribose) polymerase-1 (PARP-1) gene fragment in antisense orientation within the pTracer vector (asPARP TUR cells) demonstrated increasing cell attachment and differentiation after TPA treatment.	Tetradecanoylphorbol Acetate	255-258	poly(ADP-ribose) polymerase 1	Homo sapiens	97-103
16256044-5	2005	(3) Compared with control, PMA, a PKC activator, increased the activity of membrane and total PKC in human pituitary adenoma cells.	Tetradecanoylphorbol Acetate	27-30	proline rich transmembrane protein 2	Homo sapiens	34-37
16309325-3	2005	Of these compounds, geniposide (3), 6alpha-hydroxygeniposide (5), ixoroside (7), and shanzhiside (8) showed significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells.	Tetradecanoylphorbol Acetate	152-177	interleukin 2	Homo sapiens	134-138
16199204-3	2005	Albumin pretreatment significantly reduced CD11b expression and L-selectin shedding induced by fMLP and ROS production induced by PMA, G-CSF combined with PMA or LPS-fMLP, or anti-HNA-1a combined with PMA.	Tetradecanoylphorbol Acetate	130-133	formyl peptide receptor 1	Homo sapiens	95-99
15994198-6	2005	In the enhancer, an Oct-1 binding site, a Pbx/Prep binding site, Msx/Dlx binding sites, and a previously unidentified protein-binding element at -1793, all contribute to TPA suppression.	Tetradecanoylphorbol Acetate	170-173	distal-less homeobox 1	Mus musculus	69-72
16256044-5	2005	(3) Compared with control, PMA, a PKC activator, increased the activity of membrane and total PKC in human pituitary adenoma cells.	Tetradecanoylphorbol Acetate	27-30	proline rich transmembrane protein 2	Homo sapiens	94-97
16188940-7	2005	We find that the behavior of Bves following low Ca2+ challenge or TPA treatment mimics that observed for ZO-1 and is distinct from adherens junction proteins such as E-cadherin.	Tetradecanoylphorbol Acetate	66-69	tight junction protein 1	Mus musculus	105-109
16154536-3	2005	Results indicate that the protein kinase C (PKC) agonist phorbol-12-myristate-13-acetate (PMA, 1 microM) could mimic the effect of TGF-beta1 (20 ng/ml) on the expression of an A-type K+ channel and induced a similar A-type K+ current.	Tetradecanoylphorbol Acetate	57-88	transforming growth factor, beta 1	Rattus norvegicus	131-140
16154536-3	2005	Results indicate that the protein kinase C (PKC) agonist phorbol-12-myristate-13-acetate (PMA, 1 microM) could mimic the effect of TGF-beta1 (20 ng/ml) on the expression of an A-type K+ channel and induced a similar A-type K+ current.	Tetradecanoylphorbol Acetate	90-93	transforming growth factor, beta 1	Rattus norvegicus	131-140
16055435-3	2005	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) in early G1 phase impaired progression of lung adenocarcinoma cells into S phase, an effect that was completely abolished by specific depletion of PKCdelta, but not PKCalpha.	Tetradecanoylphorbol Acetate	23-54	protein kinase C alpha	Homo sapiens	14-17
16055435-3	2005	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) in early G1 phase impaired progression of lung adenocarcinoma cells into S phase, an effect that was completely abolished by specific depletion of PKCdelta, but not PKCalpha.	Tetradecanoylphorbol Acetate	56-59	protein kinase C alpha	Homo sapiens	14-17
16096279-1	2005	The rate of cleavage secretion of the enzymatically active ectodomain of angiotensin-converting enzyme (ACE) is regulated by tyrosine phosphorylation of the protein and by the phorbol ester, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C. Here, we report that both calmodulin inhibitor (CaMI) and calmodulin kinase inhibitor could also enhance cleavage secretion of ACE.	Tetradecanoylphorbol Acetate	191-222	angiotensin I converting enzyme	Homo sapiens	73-102
16055435-3	2005	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) in early G1 phase impaired progression of lung adenocarcinoma cells into S phase, an effect that was completely abolished by specific depletion of PKCdelta, but not PKCalpha.	Tetradecanoylphorbol Acetate	56-59	protein kinase C alpha	Homo sapiens	226-234
16096279-1	2005	The rate of cleavage secretion of the enzymatically active ectodomain of angiotensin-converting enzyme (ACE) is regulated by tyrosine phosphorylation of the protein and by the phorbol ester, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C. Here, we report that both calmodulin inhibitor (CaMI) and calmodulin kinase inhibitor could also enhance cleavage secretion of ACE.	Tetradecanoylphorbol Acetate	191-222	angiotensin I converting enzyme	Homo sapiens	104-107
16096279-1	2005	The rate of cleavage secretion of the enzymatically active ectodomain of angiotensin-converting enzyme (ACE) is regulated by tyrosine phosphorylation of the protein and by the phorbol ester, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C. Here, we report that both calmodulin inhibitor (CaMI) and calmodulin kinase inhibitor could also enhance cleavage secretion of ACE.	Tetradecanoylphorbol Acetate	224-227	angiotensin I converting enzyme	Homo sapiens	73-102
16102725-6	2005	Furthermore, curcumin strongly repressed the PMA-induced phosphorylation of ERK, JNK, and p38 MAP kinase, which were dependent on the PKC pathway.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase 8	Homo sapiens	81-84
16041399-4	2005	Transient gene expression assays using human cox-2 promoter construct revealed that ethyl caffeate exerted an inhibitory effect on cox-2 transcriptional activity in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	165-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
16102725-6	2005	Furthermore, curcumin strongly repressed the PMA-induced phosphorylation of ERK, JNK, and p38 MAP kinase, which were dependent on the PKC pathway.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase 14	Homo sapiens	90-93
16096279-1	2005	The rate of cleavage secretion of the enzymatically active ectodomain of angiotensin-converting enzyme (ACE) is regulated by tyrosine phosphorylation of the protein and by the phorbol ester, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C. Here, we report that both calmodulin inhibitor (CaMI) and calmodulin kinase inhibitor could also enhance cleavage secretion of ACE.	Tetradecanoylphorbol Acetate	224-227	angiotensin I converting enzyme	Homo sapiens	104-107
16096279-1	2005	The rate of cleavage secretion of the enzymatically active ectodomain of angiotensin-converting enzyme (ACE) is regulated by tyrosine phosphorylation of the protein and by the phorbol ester, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C. Here, we report that both calmodulin inhibitor (CaMI) and calmodulin kinase inhibitor could also enhance cleavage secretion of ACE.	Tetradecanoylphorbol Acetate	224-227	calmodulin 1	Homo sapiens	290-317
16096279-1	2005	The rate of cleavage secretion of the enzymatically active ectodomain of angiotensin-converting enzyme (ACE) is regulated by tyrosine phosphorylation of the protein and by the phorbol ester, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C. Here, we report that both calmodulin inhibitor (CaMI) and calmodulin kinase inhibitor could also enhance cleavage secretion of ACE.	Tetradecanoylphorbol Acetate	224-227	calmodulin 1	Homo sapiens	290-300
16096279-1	2005	The rate of cleavage secretion of the enzymatically active ectodomain of angiotensin-converting enzyme (ACE) is regulated by tyrosine phosphorylation of the protein and by the phorbol ester, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C. Here, we report that both calmodulin inhibitor (CaMI) and calmodulin kinase inhibitor could also enhance cleavage secretion of ACE.	Tetradecanoylphorbol Acetate	224-227	angiotensin I converting enzyme	Homo sapiens	391-394
15893895-8	2005	CA also inhibited interleukin-8 and tumor necrosis factor-alpha secretion from the phorbol 12-myristate 13-acetate and A23187-induced HMC-1 cells (human mast cell line).	Tetradecanoylphorbol Acetate	83-114	C-X-C motif chemokine ligand 8	Homo sapiens	18-63
16151632-7	2005	Activation of the ERK signaling pathway by phorbol myristate 13-acetate (PMA) and sorbitol protected K562 cells from serum deprivation induced apoptosis.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase 1	Homo sapiens	18-21
16041399-4	2005	Transient gene expression assays using human cox-2 promoter construct revealed that ethyl caffeate exerted an inhibitory effect on cox-2 transcriptional activity in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	165-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
16041399-4	2005	Transient gene expression assays using human cox-2 promoter construct revealed that ethyl caffeate exerted an inhibitory effect on cox-2 transcriptional activity in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	203-206	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
16179731-8	2005	However, Tat treatment enhanced phorbol myristate acetate (PMA)-induced megakaryocytic differentiation, as evident from a 180-210% increase in 3H-serotonin uptake and a 5-12-fold increase in CD61 expression.	Tetradecanoylphorbol Acetate	32-57	integrin subunit beta 3	Homo sapiens	191-195
16179737-6	2005	Furthermore, AXE attenuated the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187)-stimulated tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 secretion in human mast cells.	Tetradecanoylphorbol Acetate	32-63	tumor necrosis factor	Homo sapiens	113-140
16179737-6	2005	Furthermore, AXE attenuated the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187)-stimulated tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 secretion in human mast cells.	Tetradecanoylphorbol Acetate	32-63	tumor necrosis factor	Homo sapiens	142-151
16179731-8	2005	However, Tat treatment enhanced phorbol myristate acetate (PMA)-induced megakaryocytic differentiation, as evident from a 180-210% increase in 3H-serotonin uptake and a 5-12-fold increase in CD61 expression.	Tetradecanoylphorbol Acetate	59-62	integrin subunit beta 3	Homo sapiens	191-195
16179737-6	2005	Furthermore, AXE attenuated the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187)-stimulated tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 secretion in human mast cells.	Tetradecanoylphorbol Acetate	32-63	interleukin 6	Homo sapiens	157-175
16179737-6	2005	Furthermore, AXE attenuated the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187)-stimulated tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 secretion in human mast cells.	Tetradecanoylphorbol Acetate	65-68	tumor necrosis factor	Homo sapiens	113-140
16179737-6	2005	Furthermore, AXE attenuated the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187)-stimulated tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 secretion in human mast cells.	Tetradecanoylphorbol Acetate	65-68	tumor necrosis factor	Homo sapiens	142-151
16179737-6	2005	Furthermore, AXE attenuated the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187)-stimulated tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 secretion in human mast cells.	Tetradecanoylphorbol Acetate	65-68	interleukin 6	Homo sapiens	157-175
16142309-6	2005	Treatment of HL-60 cells with TPA (0.64-3.2 nM) caused a rapid activation of NF-kappaB as determined by electrophoresis mobility shift assay (EMSA) and immunocytochemistry.	Tetradecanoylphorbol Acetate	30-33	nuclear factor kappa B subunit 1	Homo sapiens	77-86
16142309-0	2005	Enhancement of TPA-induced growth inhibition and apoptosis in myeloid leukemia cells by BAY 11-7082, an NF-kappaB inhibitor.	Tetradecanoylphorbol Acetate	15-18	nuclear factor kappa B subunit 1	Homo sapiens	104-113
16142309-7	2005	Although the basal level of NF-kappaB activity was low in HL-60 cells, TPA-resistant HL-525 cells had a high basal level of NF-kappaB activity.	Tetradecanoylphorbol Acetate	71-74	nuclear factor kappa B subunit 1	Homo sapiens	28-37
16142309-2	2005	In the present study, we investigated the role of the transcription factor NF-kappaB in TPA-induced growth inhibition and apoptosis in the myeloid leukemia HL-60 cell line and its TPA-resistant cell variant HL-525.	Tetradecanoylphorbol Acetate	88-91	nuclear factor kappa B subunit 1	Homo sapiens	75-84
16142309-7	2005	Although the basal level of NF-kappaB activity was low in HL-60 cells, TPA-resistant HL-525 cells had a high basal level of NF-kappaB activity.	Tetradecanoylphorbol Acetate	71-74	nuclear factor kappa B subunit 1	Homo sapiens	124-133
16142309-8	2005	Treatment of HL-525 cells with higher concentrations of TPA (16-80 nM) resulted in a further increase in NF-kappaB activity.	Tetradecanoylphorbol Acetate	56-59	nuclear factor kappa B subunit 1	Homo sapiens	105-114
16142309-11	2005	Results from the present study indicate that inhibition of NF-kappaB by BAY was associated with enhanced TPA-induced growth inhibition and apoptosis in human myeloid leukemia cells.	Tetradecanoylphorbol Acetate	105-108	nuclear factor kappa B subunit 1	Homo sapiens	59-68
16142309-12	2005	TPA in combination with pharmacological inhibitors of NF-kappaB may improve the therapeutic efficacy of TPA and overcome the resistance to TPA in some myeloid leukemia patients.	Tetradecanoylphorbol Acetate	104-107	nuclear factor kappa B subunit 1	Homo sapiens	54-63
16142309-12	2005	TPA in combination with pharmacological inhibitors of NF-kappaB may improve the therapeutic efficacy of TPA and overcome the resistance to TPA in some myeloid leukemia patients.	Tetradecanoylphorbol Acetate	104-107	nuclear factor kappa B subunit 1	Homo sapiens	54-63
16044405-9	2005	Three genes, Gsta4, Nmes1 (MGC58382), and Serpinb2, located within promotion susceptibility loci Psl1 (chr 9), Psl2 (chr 2), and Psl3 (chr 1), respectively, were identified in this analysis as potential candidates for modifiers of susceptibility to skin tumor promotion by TPA.	Tetradecanoylphorbol Acetate	273-276	promotion susceptibility QTL 1	Mus musculus	97-101
16111532-4	2005	TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64.	Tetradecanoylphorbol Acetate	0-3	CD4 molecule	Homo sapiens	101-104
16111532-4	2005	TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64.	Tetradecanoylphorbol Acetate	0-3	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	143-148
15976015-8	2005	Treatment with the TPA/ATRA combination resulted in a substantially decreased ratio of the percentage of mitotic cells to the percentage of caspase-3-positive cells in the tumors compared with tumors from the vehicle-treated control animals.	Tetradecanoylphorbol Acetate	19-22	caspase 3	Homo sapiens	140-149
16044407-6	2005	The induction of COX-2 elicited by TPA correlated with increased activation of Akt kinase and cell treatment with the PI3 kinase inhibitor, LY294002, blocked TPA induction of COX-2.	Tetradecanoylphorbol Acetate	158-161	prostaglandin-endoperoxide synthase 2	Homo sapiens	17-22
16044407-6	2005	The induction of COX-2 elicited by TPA correlated with increased activation of Akt kinase and cell treatment with the PI3 kinase inhibitor, LY294002, blocked TPA induction of COX-2.	Tetradecanoylphorbol Acetate	158-161	AKT serine/threonine kinase 1	Homo sapiens	79-82
16044405-9	2005	Three genes, Gsta4, Nmes1 (MGC58382), and Serpinb2, located within promotion susceptibility loci Psl1 (chr 9), Psl2 (chr 2), and Psl3 (chr 1), respectively, were identified in this analysis as potential candidates for modifiers of susceptibility to skin tumor promotion by TPA.	Tetradecanoylphorbol Acetate	273-276	promotion susceptibility QTL 3	Mus musculus	129-133
16044407-6	2005	The induction of COX-2 elicited by TPA correlated with increased activation of Akt kinase and cell treatment with the PI3 kinase inhibitor, LY294002, blocked TPA induction of COX-2.	Tetradecanoylphorbol Acetate	158-161	prostaglandin-endoperoxide synthase 2	Homo sapiens	175-180
16044407-7	2005	In cells treated with TPA and apigenin, the inhibition of COX-2 expression correlated with inhibition of Akt kinase activation.	Tetradecanoylphorbol Acetate	22-25	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-63
16044407-0	2005	Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes.	Tetradecanoylphorbol Acetate	14-17	prostaglandin-endoperoxide synthase 2	Homo sapiens	26-42
16044407-7	2005	In cells treated with TPA and apigenin, the inhibition of COX-2 expression correlated with inhibition of Akt kinase activation.	Tetradecanoylphorbol Acetate	22-25	AKT serine/threonine kinase 1	Homo sapiens	105-108
16044407-0	2005	Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes.	Tetradecanoylphorbol Acetate	14-17	prostaglandin-endoperoxide synthase 2	Homo sapiens	44-49
16044407-8	2005	Apigenin-mediated inhibition of TPA-induced COX-2 expression was reversed by transient transfection with constitutively active Akt (CA-Akt).	Tetradecanoylphorbol Acetate	32-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	44-49
16044407-8	2005	Apigenin-mediated inhibition of TPA-induced COX-2 expression was reversed by transient transfection with constitutively active Akt (CA-Akt).	Tetradecanoylphorbol Acetate	32-35	AKT serine/threonine kinase 1	Homo sapiens	127-130
16044407-0	2005	Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes.	Tetradecanoylphorbol Acetate	14-17	AKT serine/threonine kinase 1	Homo sapiens	100-103
16044407-8	2005	Apigenin-mediated inhibition of TPA-induced COX-2 expression was reversed by transient transfection with constitutively active Akt (CA-Akt).	Tetradecanoylphorbol Acetate	32-35	AKT serine/threonine kinase 1	Homo sapiens	135-138
16044407-2	2005	These DMBA/TPA-induced squamous cell carcinomas overexpress cyclooxygenase-2 (COX-2).	Tetradecanoylphorbol Acetate	11-14	prostaglandin-endoperoxide synthase 2	Homo sapiens	60-76
16044407-9	2005	Chemical inhibitors of MEK (PD98059), p38 (SB202190), but not JNK (SP600125) blocked TPA induction of COX-2 although apigenin did not inhibit TPA-mediated COX-2 expression through these pathways.	Tetradecanoylphorbol Acetate	85-88	mitogen-activated protein kinase 14	Homo sapiens	38-41
16044407-9	2005	Chemical inhibitors of MEK (PD98059), p38 (SB202190), but not JNK (SP600125) blocked TPA induction of COX-2 although apigenin did not inhibit TPA-mediated COX-2 expression through these pathways.	Tetradecanoylphorbol Acetate	85-88	prostaglandin-endoperoxide synthase 2	Homo sapiens	102-107
16044407-11	2005	These data show that apigenin inhibits TPA-mediated COX-2 expression by blocking signal transduction of Akt and that apigenin also blocks AA release, which may contribute to its chemopreventive activity.	Tetradecanoylphorbol Acetate	39-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-57
16044407-11	2005	These data show that apigenin inhibits TPA-mediated COX-2 expression by blocking signal transduction of Akt and that apigenin also blocks AA release, which may contribute to its chemopreventive activity.	Tetradecanoylphorbol Acetate	39-42	AKT serine/threonine kinase 1	Homo sapiens	104-107
16044407-2	2005	These DMBA/TPA-induced squamous cell carcinomas overexpress cyclooxygenase-2 (COX-2).	Tetradecanoylphorbol Acetate	11-14	prostaglandin-endoperoxide synthase 2	Homo sapiens	78-83
16044407-5	2005	In the present study, we have determined that apigenin inhibited the TPA-induced increase in COX-2 protein and mRNA in the human keratinocyte cell line; HaCaT.	Tetradecanoylphorbol Acetate	69-72	prostaglandin-endoperoxide synthase 2	Homo sapiens	93-98
16044407-6	2005	The induction of COX-2 elicited by TPA correlated with increased activation of Akt kinase and cell treatment with the PI3 kinase inhibitor, LY294002, blocked TPA induction of COX-2.	Tetradecanoylphorbol Acetate	35-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	17-22
16044407-6	2005	The induction of COX-2 elicited by TPA correlated with increased activation of Akt kinase and cell treatment with the PI3 kinase inhibitor, LY294002, blocked TPA induction of COX-2.	Tetradecanoylphorbol Acetate	35-38	AKT serine/threonine kinase 1	Homo sapiens	79-82
16150543-5	2005	Acute nocifensive behaviour after intraplantar injection of phorbol 12-myristate 13-acetate, an activator of protein kinase C (PKC), was absent in TRPV1 KO animals showing that PKC activation elicits nociception exclusively through TRPV1 receptor sensitization/activation.	Tetradecanoylphorbol Acetate	60-91	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	232-237
16049272-7	2005	Binary mixtures of TPA with triclopyr also caused greater than additive Vtg responses in two middle concentrations when compared to TPA or triclopyr alone.	Tetradecanoylphorbol Acetate	19-22	LOC100136735	Oncorhynchus mykiss	72-75
16141421-8	2005	RESULTS: Hypercapnic (Pco2 75 mm Hg) and hypotensive (mean arterial blood pressure decreased by 45%) pial artery dilation (PAD) was blunted after H/I and reversed to vasoconstriction in animals pretreated with tPA or uPA (10(-7) mol/L; 26+/-2, 11+/-1, and -4+/-1% for hypercapnia before, after H/I, and after H/I with tPA).	Tetradecanoylphorbol Acetate	210-213	PCO2	Sus scrofa	22-26
16254825-5	2005	FMLP-induced tyrosyl phosphorylation or PMA-induced serine/threonine phosphorylation and the translocation of the cytosolic proteins p47(phox) and p67(phox) to the cell membrane were suppressed in parallel to the suppression of the stimulus-induced superoxide generation.	Tetradecanoylphorbol Acetate	40-43	formyl peptide receptor 1	Homo sapiens	0-4
16254825-5	2005	FMLP-induced tyrosyl phosphorylation or PMA-induced serine/threonine phosphorylation and the translocation of the cytosolic proteins p47(phox) and p67(phox) to the cell membrane were suppressed in parallel to the suppression of the stimulus-induced superoxide generation.	Tetradecanoylphorbol Acetate	40-43	CD33 molecule	Homo sapiens	147-150
16141421-8	2005	RESULTS: Hypercapnic (Pco2 75 mm Hg) and hypotensive (mean arterial blood pressure decreased by 45%) pial artery dilation (PAD) was blunted after H/I and reversed to vasoconstriction in animals pretreated with tPA or uPA (10(-7) mol/L; 26+/-2, 11+/-1, and -4+/-1% for hypercapnia before, after H/I, and after H/I with tPA).	Tetradecanoylphorbol Acetate	318-321	PCO2	Sus scrofa	22-26
16049272-8	2005	When trout were exposed to water collected from a site where triclopyr was used in combination with TPA, a concentration-dependent increase in Vtg expression was observed.	Tetradecanoylphorbol Acetate	100-103	LOC100136735	Oncorhynchus mykiss	143-146
16125151-6	2005	Peripheral activation of PKC using the phorbol ester phorbol-12-myristate-13-acetate (PMA) mimicked the pro-nociceptive effect of GAL.	Tetradecanoylphorbol Acetate	53-84	galanin and GMAP prepropeptide	Rattus norvegicus	130-133
16055447-3	2005	In this study, we investigated the role of cysteine string protein (csp) in phorbol-12-myristate-13-acetate-evoked cortical granule exocytosis.	Tetradecanoylphorbol Acetate	76-107	DnaJ heat shock protein family (Hsp40) member C5 S homeolog	Xenopus laevis	43-66
16055447-3	2005	In this study, we investigated the role of cysteine string protein (csp) in phorbol-12-myristate-13-acetate-evoked cortical granule exocytosis.	Tetradecanoylphorbol Acetate	76-107	DnaJ heat shock protein family (Hsp40) member C5 S homeolog	Xenopus laevis	68-71
16156648-5	2005	We found that replacing syndecan-1 juxtamembrane amino acid residues A243-S-Q-S-L247 with human CD4 amino acid residues can completely block PMA-induced syndecan-1 ectodomain shedding.	Tetradecanoylphorbol Acetate	141-144	CD4 molecule	Homo sapiens	96-99
16277846-6	2005	In ATRA and TPA group, the change of HSP70 had positive correlation with JWA, and negative correlation with Bcl-2.	Tetradecanoylphorbol Acetate	12-15	BCL2 apoptosis regulator	Homo sapiens	108-113
16125151-6	2005	Peripheral activation of PKC using the phorbol ester phorbol-12-myristate-13-acetate (PMA) mimicked the pro-nociceptive effect of GAL.	Tetradecanoylphorbol Acetate	86-89	galanin and GMAP prepropeptide	Rattus norvegicus	130-133
16055081-10	2005	Zn2+ also suppressed IL-2 mRNA expression induced by phorbol ester (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	68-71	interleukin 2	Homo sapiens	21-25
16115026-7	2005	Moreover, phorbol 12-myristate 13-acetate-initiated ROS formation, which was attenuated in macrophages pretreated with IFNgamma, was restored in the presence of the PC-PLC inhibitor.	Tetradecanoylphorbol Acetate	10-41	interferon gamma	Homo sapiens	119-127
16156895-6	2005	However, if NOX was activated (by PMA or BzATP) in the presence of iNOS (induced by LPS and interferon-gamma) then substantial delayed neuronal death occurred over 48 hours, which was prevented by inhibitors of iNOS (1400W), NOX (apocynin) or a peroxynitrite decomposer (FeTPPS).	Tetradecanoylphorbol Acetate	34-37	nitric oxide synthase 2	Rattus norvegicus	67-71
16156895-6	2005	However, if NOX was activated (by PMA or BzATP) in the presence of iNOS (induced by LPS and interferon-gamma) then substantial delayed neuronal death occurred over 48 hours, which was prevented by inhibitors of iNOS (1400W), NOX (apocynin) or a peroxynitrite decomposer (FeTPPS).	Tetradecanoylphorbol Acetate	34-37	nitric oxide synthase 2	Rattus norvegicus	211-215
16159396-3	2005	METHODS: Human lung fibroblast were co-cultured with PMA-ionomycin activated T-CD4 lymphocytes for 36 hours.	Tetradecanoylphorbol Acetate	53-56	CD4 molecule	Homo sapiens	79-82
16080188-4	2005	Detection of phospho-Thr 202/Tyr 204-p44/42 extracellular-regulated kinase (ERK) after phorbol ester acetate (PMA) stimulation was used as a model to measure phospho-epitopes in leukocyte populations in whole blood.	Tetradecanoylphorbol Acetate	110-113	mitogen-activated protein kinase 1	Homo sapiens	44-74
16156860-4	2005	TPA-stimulated HEL cells normally undergo: (1) growth arrest; (2) altered morphology; (3) endomitosis and (4) characteristic changes in gene expression, including reduction of the erythroid-specific glycophoryn A and elevation of the specific glycoproteins GPIIIa and GPVI.	Tetradecanoylphorbol Acetate	0-3	integrin subunit beta 3	Homo sapiens	257-263
16156860-6	2005	Evi1-expressing, TPA-treated HEL cells still showed growth arrest, had reduced and enhanced glycophoryn A and GPIIIa mRNA"s, respectively, but failed to significantly elevate GPVI mRNA.	Tetradecanoylphorbol Acetate	17-20	integrin subunit beta 3	Homo sapiens	110-116
16156860-8	2005	Sustained CDK2 catalytic activity, typically associated with megakaryocyte endomitosis, was dramatically decreased in TPA-stimulated Evi1-expressing HEL cells because of significantly reduced levels of cyclin A.	Tetradecanoylphorbol Acetate	118-121	cyclin A2	Homo sapiens	202-210
16098762-10	2005	Whereas N-formyl-methionyl-leucylphenylalanine (fMLP), platelet-activating factor (PAF) and basal stimulation resulted in similar IC50 values, phorbol-12-myristate-13-acetate (PMA) as a stimulant needed higher concentrations of SLs.	Tetradecanoylphorbol Acetate	143-174	formyl peptide receptor 1	Homo sapiens	48-52
16045733-5	2005	As a result of it the amount of interferon-gamma producing CD7(+) T-cells and the concentration of interferon-gamma in cultural supernatants were maximal in the cell cultures incubated with anti-CD3, interleukin-7 and dexamethasone during the first 68 h and subsequently restimulated with phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	289-320	interferon gamma	Homo sapiens	32-48
16045733-5	2005	As a result of it the amount of interferon-gamma producing CD7(+) T-cells and the concentration of interferon-gamma in cultural supernatants were maximal in the cell cultures incubated with anti-CD3, interleukin-7 and dexamethasone during the first 68 h and subsequently restimulated with phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	289-320	interferon gamma	Homo sapiens	99-115
16080188-4	2005	Detection of phospho-Thr 202/Tyr 204-p44/42 extracellular-regulated kinase (ERK) after phorbol ester acetate (PMA) stimulation was used as a model to measure phospho-epitopes in leukocyte populations in whole blood.	Tetradecanoylphorbol Acetate	110-113	mitogen-activated protein kinase 1	Homo sapiens	76-79
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	44-69	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
16122920-6	2005	Both DCA and phorbol myristate acetate (PMA) but not UDCA caused translocation of endogenous PKC alpha, epsilon and delta and transfected PKC beta1-, epsilon- and delta-EGFP from cytosol to plasma membrane, reflecting isoenzyme activation.	Tetradecanoylphorbol Acetate	13-38	protein kinase C alpha	Homo sapiens	93-121
16122920-6	2005	Both DCA and phorbol myristate acetate (PMA) but not UDCA caused translocation of endogenous PKC alpha, epsilon and delta and transfected PKC beta1-, epsilon- and delta-EGFP from cytosol to plasma membrane, reflecting isoenzyme activation.	Tetradecanoylphorbol Acetate	40-43	protein kinase C alpha	Homo sapiens	93-121
16123409-9	2005	Treatment of the corneal epithelial cells with 12-O-tetradecanoylphorbol-13-acetate increased hINV gene expression and this response is associated with increased nuclear factor binding of Sp1 and Sp3 to the Sp DNA response element.	Tetradecanoylphorbol Acetate	47-83	Sp3 transcription factor	Homo sapiens	196-199
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	44-69	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	44-69	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
16087121-9	2005	RESULTS: BALF1 expression was detected in the latent stage and increased more significantly during the lytic phase in IgG-treated AKATA and TPA-SB-treated P3HR1-TK negative cell lines.	Tetradecanoylphorbol Acetate	140-143	apoptosis regulator BALF1	Human gammaherpesvirus 4	9-14
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	182-185	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	182-185	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	182-185	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
16077980-5	2005	One DNA-protein complex was formed by DNA mobility shift assay when the NF-kappaB or AP-1 binding sites were incubated with nuclear extract prepared from TPA-treated HL-60 cells, but no protein bound in control HL-60 cells without TPA.	Tetradecanoylphorbol Acetate	154-157	nuclear factor kappa B subunit 1	Homo sapiens	72-81
16181054-4	2005	The addition of IFN-gamma, alone or in combination with TNF-alpha, increased spontaneous superoxide release by PBM and THP-1 cells (p &lt; 0.05) and increased phorbol myristate acetate (PMA)-stimulated superoxide release by CM, PBM, and THP-1 cells (p &lt; 0.05).	Tetradecanoylphorbol Acetate	159-184	interferon gamma	Homo sapiens	16-25
16181054-4	2005	The addition of IFN-gamma, alone or in combination with TNF-alpha, increased spontaneous superoxide release by PBM and THP-1 cells (p &lt; 0.05) and increased phorbol myristate acetate (PMA)-stimulated superoxide release by CM, PBM, and THP-1 cells (p &lt; 0.05).	Tetradecanoylphorbol Acetate	159-184	tumor necrosis factor	Homo sapiens	56-65
16181054-4	2005	The addition of IFN-gamma, alone or in combination with TNF-alpha, increased spontaneous superoxide release by PBM and THP-1 cells (p &lt; 0.05) and increased phorbol myristate acetate (PMA)-stimulated superoxide release by CM, PBM, and THP-1 cells (p &lt; 0.05).	Tetradecanoylphorbol Acetate	186-189	interferon gamma	Homo sapiens	16-25
16181054-4	2005	The addition of IFN-gamma, alone or in combination with TNF-alpha, increased spontaneous superoxide release by PBM and THP-1 cells (p &lt; 0.05) and increased phorbol myristate acetate (PMA)-stimulated superoxide release by CM, PBM, and THP-1 cells (p &lt; 0.05).	Tetradecanoylphorbol Acetate	186-189	tumor necrosis factor	Homo sapiens	56-65
16135804-4	2005	Our results demonstrate a binding of HuR to the SLC11A1 ARE in phorbol myristate acetate (PMA)-differentiated cells dramatically increased compared to that in undifferentiated cells.	Tetradecanoylphorbol Acetate	63-88	solute carrier family 11 member 1	Homo sapiens	48-55
16135804-4	2005	Our results demonstrate a binding of HuR to the SLC11A1 ARE in phorbol myristate acetate (PMA)-differentiated cells dramatically increased compared to that in undifferentiated cells.	Tetradecanoylphorbol Acetate	90-93	solute carrier family 11 member 1	Homo sapiens	48-55
16148738-1	2005	BACKGROUND: Reviews of the use of intravenous tissue type plasminogen activator (IV tPA) for acute stroke in community hospitals have raised questions regarding its safe use in community practice settings outside major academic stroke centers.	Tetradecanoylphorbol Acetate	84-87	plasminogen activator, tissue type	Homo sapiens	46-79
15917399-5	2005	Depletion of PKC by phorbol-12-myristate-13-acetate (10 microM) blocked SP-induced IkappaBalpha and p65 phosphorylation and IL-8 production.	Tetradecanoylphorbol Acetate	20-51	NFKB inhibitor alpha	Homo sapiens	83-95
15917399-5	2005	Depletion of PKC by phorbol-12-myristate-13-acetate (10 microM) blocked SP-induced IkappaBalpha and p65 phosphorylation and IL-8 production.	Tetradecanoylphorbol Acetate	20-51	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
16135804-5	2005	Interestingly, PMA-induced accumulation of cytoplasmic HuR occurs in parallel with an increase in the binding of HuR to SLC11A1 ARE and with an increase in the SLC11A1 mRNA level.	Tetradecanoylphorbol Acetate	15-18	solute carrier family 11 member 1	Homo sapiens	120-127
16135804-5	2005	Interestingly, PMA-induced accumulation of cytoplasmic HuR occurs in parallel with an increase in the binding of HuR to SLC11A1 ARE and with an increase in the SLC11A1 mRNA level.	Tetradecanoylphorbol Acetate	15-18	solute carrier family 11 member 1	Homo sapiens	160-167
16099101-2	2005	Therefore, the present study attempted to assess some of the mechanisms involved in the overt nociception elicited by peripheral administration of the PKC activator, phorbol 12-myristate 13-acetate (PMA), in mice.	Tetradecanoylphorbol Acetate	166-197	protein kinase C, alpha	Mus musculus	151-154
16099101-2	2005	Therefore, the present study attempted to assess some of the mechanisms involved in the overt nociception elicited by peripheral administration of the PKC activator, phorbol 12-myristate 13-acetate (PMA), in mice.	Tetradecanoylphorbol Acetate	199-202	protein kinase C, alpha	Mus musculus	151-154
16099101-4	2005	injection of PMA (16-1600 pmol/paw), but not its inactive analogue alpha-PMA, produced a long-lasting overt nociception (up to 45 min), as well as the activation of PKCalpha and PKCepsilon isoforms in treated paws.	Tetradecanoylphorbol Acetate	13-16	protein kinase C, alpha	Mus musculus	165-173
16099101-5	2005	Indeed, the local administration of the PKC inhibitor GF109203X completely blocked PMA-induced nociception.	Tetradecanoylphorbol Acetate	83-86	protein kinase C, alpha	Mus musculus	40-43
16077980-5	2005	One DNA-protein complex was formed by DNA mobility shift assay when the NF-kappaB or AP-1 binding sites were incubated with nuclear extract prepared from TPA-treated HL-60 cells, but no protein bound in control HL-60 cells without TPA.	Tetradecanoylphorbol Acetate	231-234	nuclear factor kappa B subunit 1	Homo sapiens	72-81
16099101-6	2005	The blockade of NK1, CGRP, NMDA, beta1-adrenergic, B2 or TRPV1 receptors with selective antagonists partially decreased PMA-induced nociception.	Tetradecanoylphorbol Acetate	120-123	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	21-25
16099101-6	2005	The blockade of NK1, CGRP, NMDA, beta1-adrenergic, B2 or TRPV1 receptors with selective antagonists partially decreased PMA-induced nociception.	Tetradecanoylphorbol Acetate	120-123	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	57-62
16077980-7	2005	Taken together, these results suggest that NF-kappaB may be an essential transacting factor for transcriptional repression of the vimentin gene by PDTC during TPA-dependent differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	159-162	nuclear factor kappa B subunit 1	Homo sapiens	43-52
16026998-2	2005	In the cells activated by the protein kinase C specific phorbol ester (phorbol 12-myristate 13-acetate) and Ca(2+) ionophore (A23187) both adenosine and the subtype-specific receptor agonists, CPA (A1), CGS 21680 (A2A) and IB-MECA (A3) induced a concentration-dependent inhibition of IL-1beta release.	Tetradecanoylphorbol Acetate	71-102	carboxypeptidase A1	Homo sapiens	193-196
16188211-12	2005	Two isoforms of PLD, oleate-dependent and TPA-dependent, are also present in LA-N-1 cell homogenates.	Tetradecanoylphorbol Acetate	42-45	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	16-19
16358840-6	2005	Blood sample was obtained from patients and examined for the expression of Interleukin 2 and 4 by intracellular staining procedure, after stimulation with PMA (phorbol 12-myristate 13-acetate) and allergen (D. pteronyssimus, Allergopharma).	Tetradecanoylphorbol Acetate	155-158	interleukin 2	Homo sapiens	75-94
16358840-6	2005	Blood sample was obtained from patients and examined for the expression of Interleukin 2 and 4 by intracellular staining procedure, after stimulation with PMA (phorbol 12-myristate 13-acetate) and allergen (D. pteronyssimus, Allergopharma).	Tetradecanoylphorbol Acetate	160-191	interleukin 2	Homo sapiens	75-94
15975933-3	2005	In U937/PR3, stably transfected with PRCRSV/PR3 to overexpress PR3, PMA-induced p21 expression was significantly decreased as compared with control U937, and this phenomenon was reversed in the presence of the serine proteinase inhibitor, pefabloc.	Tetradecanoylphorbol Acetate	68-71	cyclin dependent kinase inhibitor 1A	Homo sapiens	80-83
15975933-9	2005	Moreover, PMA-induced p21 expression was more pronounced in U937/p21A45R compared with U937/p21 and was concomitant with the morphological features of early differentiation.	Tetradecanoylphorbol Acetate	10-13	cyclin dependent kinase inhibitor 1A	Homo sapiens	22-25
15975933-9	2005	Moreover, PMA-induced p21 expression was more pronounced in U937/p21A45R compared with U937/p21 and was concomitant with the morphological features of early differentiation.	Tetradecanoylphorbol Acetate	10-13	cyclin dependent kinase inhibitor 1A	Homo sapiens	65-68
16026998-2	2005	In the cells activated by the protein kinase C specific phorbol ester (phorbol 12-myristate 13-acetate) and Ca(2+) ionophore (A23187) both adenosine and the subtype-specific receptor agonists, CPA (A1), CGS 21680 (A2A) and IB-MECA (A3) induced a concentration-dependent inhibition of IL-1beta release.	Tetradecanoylphorbol Acetate	71-102	interleukin 1 beta	Homo sapiens	284-292
16103087-2	2005	PKCalpha-deficient mice exhibited increased susceptibility to tumor formation in two-stage skin carcinogenesis by single application of 7,12-dimethylbenz(a)anthracene (DMBA) for tumor initiation and repeated applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) for tumor promotion.	Tetradecanoylphorbol Acetate	224-260	protein kinase C, alpha	Mus musculus	0-8
16103087-2	2005	PKCalpha-deficient mice exhibited increased susceptibility to tumor formation in two-stage skin carcinogenesis by single application of 7,12-dimethylbenz(a)anthracene (DMBA) for tumor initiation and repeated applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) for tumor promotion.	Tetradecanoylphorbol Acetate	262-265	protein kinase C, alpha	Mus musculus	0-8
16042408-3	2005	In vivo phosphorylation studies in COS-1 cells transfected with murine PPARalpha showed that the level of phosphorylated PPARalpha is increased by treatment with the PP Wy-14,643 as well as the PKC activator phorbol myristol acetate (PMA).	Tetradecanoylphorbol Acetate	234-237	peroxisome proliferator activated receptor alpha	Mus musculus	71-80
15869801-5	2005	For this purpose, transcription of IL2 mRNA was quantified by real-time polymerase chain reaction in unstimulated PBMC and in PBMC incubated for 4h in the presence of concanavalin A (ConA) or phorbol 12-myristate 13-acetate plus ionomycin (PMA/I).	Tetradecanoylphorbol Acetate	192-223	interleukin-2	Ovis aries	35-38
16042408-3	2005	In vivo phosphorylation studies in COS-1 cells transfected with murine PPARalpha showed that the level of phosphorylated PPARalpha is increased by treatment with the PP Wy-14,643 as well as the PKC activator phorbol myristol acetate (PMA).	Tetradecanoylphorbol Acetate	234-237	peroxisome proliferator activated receptor alpha	Mus musculus	121-130
16045763-3	2005	We sought to identify proteins that interact with PLD1 after phorbol 12-myristate 13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	61-92	phospholipase D1	Homo sapiens	50-54
16061178-4	2005	Ser129 phosphorylation augments JNK phosphorylation by MKK4 and/or MKK7 and is required for JNK activation by TPA, TNFalpha, UV irradiation, and PKC, but not by anisomycin or MEKK1.	Tetradecanoylphorbol Acetate	110-113	mitogen-activated protein kinase kinase kinase 1	Mus musculus	175-180
15764646-8	2005	Pretreatment with PKC inhibitor Go-6983 (concentrations selective for classic PKC), PMA-induced depletion of PKCalpha, and transfection of antisense PKCalpha oligonucleotide each prevented 40-50% of the LPC-induced resistance decrease.	Tetradecanoylphorbol Acetate	84-87	protein kinase C alpha	Homo sapiens	109-117
16061658-7	2005	Coexpression of WWOX and ErbB-4 in HeLa cells followed by treatment with TPA results in the retention of ErbB-4 in the cytoplasm.	Tetradecanoylphorbol Acetate	73-76	WW domain containing oxidoreductase	Homo sapiens	16-20
15996188-5	2005	Furthermore, the percentages of the T cells isolated from the spleens of DBA/2 mice exposed to both mercury and LPS that produced pro-inflammatory cytokines were markedly increased by in vitro stimulation with phorbol myristate acetate (PMA) and ionomycin, which was not the case for splenic T cells isolated from mice receiving mercuric chloride, LPS or saline alone.	Tetradecanoylphorbol Acetate	210-235	toll-like receptor 4	Mus musculus	112-115
15996188-5	2005	Furthermore, the percentages of the T cells isolated from the spleens of DBA/2 mice exposed to both mercury and LPS that produced pro-inflammatory cytokines were markedly increased by in vitro stimulation with phorbol myristate acetate (PMA) and ionomycin, which was not the case for splenic T cells isolated from mice receiving mercuric chloride, LPS or saline alone.	Tetradecanoylphorbol Acetate	210-235	toll-like receptor 4	Mus musculus	348-351
15996188-5	2005	Furthermore, the percentages of the T cells isolated from the spleens of DBA/2 mice exposed to both mercury and LPS that produced pro-inflammatory cytokines were markedly increased by in vitro stimulation with phorbol myristate acetate (PMA) and ionomycin, which was not the case for splenic T cells isolated from mice receiving mercuric chloride, LPS or saline alone.	Tetradecanoylphorbol Acetate	237-240	toll-like receptor 4	Mus musculus	112-115
15996188-5	2005	Furthermore, the percentages of the T cells isolated from the spleens of DBA/2 mice exposed to both mercury and LPS that produced pro-inflammatory cytokines were markedly increased by in vitro stimulation with phorbol myristate acetate (PMA) and ionomycin, which was not the case for splenic T cells isolated from mice receiving mercuric chloride, LPS or saline alone.	Tetradecanoylphorbol Acetate	237-240	toll-like receptor 4	Mus musculus	348-351
15814901-3	2005	These observations were corroborated in MA-10 and mLTC-1 Leydig tumor cell lines, in which activation of PKC by phorbol-12-myristate-13-acetate (PMA, 10 nM) increased CREB phosphorylation and total StAR (tot-StAR) protein expression.	Tetradecanoylphorbol Acetate	112-143	cAMP responsive element binding protein 1	Mus musculus	167-171
15814901-4	2005	However, induction of StAR protein by PMA did not result in the expected concomitant increase in steroids because PKC failed to phosphorylate StAR, the biologically active form of the protein.	Tetradecanoylphorbol Acetate	38-41	steroidogenic acute regulatory protein	Rattus norvegicus	22-26
16045763-3	2005	We sought to identify proteins that interact with PLD1 after phorbol 12-myristate 13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	94-97	phospholipase D1	Homo sapiens	50-54
15744749-3	2005	Phosphorylation of MAPK/ERK was mimicked by phorbol 12-myristate acetate (PMA), an activator of protein kinase C (PKC), but Cch-evoked MAPK/ERK activation was unaffected by down-regulation of PKC or by pretreatment of cells with GF109203X, a PKC inhibitor.	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 1	Homo sapiens	24-27
21162213-8	2005	(2) Relative content of CD40L in PBMC in active LN groups increased significantly as compared with the control groups under spontaneous and PMA/Ionomycin-induced culture, respectively (P &lt; 0.01).	Tetradecanoylphorbol Acetate	140-143	CD40 ligand	Homo sapiens	24-29
15861394-8	2005	Further, inhibition of the AP-1 transcriptional complex by [6]-Gingerol, or by the ectopic expression of JDP2, blocked TGF-beta1-induced EMT and conversely, stimulation of AP-1 by 12-O-tetradecanoylphorbol 13-acetate (TPA) substituted for EGF in the induction of EMT by TGF-beta1 in cells containing normal Ras.	Tetradecanoylphorbol Acetate	180-216	transforming growth factor beta 1	Homo sapiens	119-128
15861394-8	2005	Further, inhibition of the AP-1 transcriptional complex by [6]-Gingerol, or by the ectopic expression of JDP2, blocked TGF-beta1-induced EMT and conversely, stimulation of AP-1 by 12-O-tetradecanoylphorbol 13-acetate (TPA) substituted for EGF in the induction of EMT by TGF-beta1 in cells containing normal Ras.	Tetradecanoylphorbol Acetate	218-221	transforming growth factor beta 1	Homo sapiens	119-128
15861394-9	2005	The presence of oncogenic Ras, the treatment of cells with EGF, or the treatment of cells with TPA to activate AP-1, potentiated TGF-beta1-induced Smad-dependent transcription, an effect that was attenuated by the inhibition of MAPKs and AP-1.	Tetradecanoylphorbol Acetate	95-98	transforming growth factor beta 1	Homo sapiens	129-138
16101361-4	2005	RESULTS: In addition to the published observations (PMA induces hBD-2 and -4; TNF-alpha induces hBD-2 and -3), it was found that PMA can upregulate hBD-1 and hBD-3, whereas TNF-alpha can induce hBD-4.	Tetradecanoylphorbol Acetate	52-55	defensin beta 4A	Homo sapiens	64-76
16101361-4	2005	RESULTS: In addition to the published observations (PMA induces hBD-2 and -4; TNF-alpha induces hBD-2 and -3), it was found that PMA can upregulate hBD-1 and hBD-3, whereas TNF-alpha can induce hBD-4.	Tetradecanoylphorbol Acetate	129-132	tumor necrosis factor	Homo sapiens	78-87
16101361-4	2005	RESULTS: In addition to the published observations (PMA induces hBD-2 and -4; TNF-alpha induces hBD-2 and -3), it was found that PMA can upregulate hBD-1 and hBD-3, whereas TNF-alpha can induce hBD-4.	Tetradecanoylphorbol Acetate	129-132	defensin beta 4A	Homo sapiens	96-108
16101361-4	2005	RESULTS: In addition to the published observations (PMA induces hBD-2 and -4; TNF-alpha induces hBD-2 and -3), it was found that PMA can upregulate hBD-1 and hBD-3, whereas TNF-alpha can induce hBD-4.	Tetradecanoylphorbol Acetate	129-132	defensin beta 1	Homo sapiens	148-153
16101361-4	2005	RESULTS: In addition to the published observations (PMA induces hBD-2 and -4; TNF-alpha induces hBD-2 and -3), it was found that PMA can upregulate hBD-1 and hBD-3, whereas TNF-alpha can induce hBD-4.	Tetradecanoylphorbol Acetate	129-132	tumor necrosis factor	Homo sapiens	173-182
16101361-4	2005	RESULTS: In addition to the published observations (PMA induces hBD-2 and -4; TNF-alpha induces hBD-2 and -3), it was found that PMA can upregulate hBD-1 and hBD-3, whereas TNF-alpha can induce hBD-4.	Tetradecanoylphorbol Acetate	129-132	defensin beta 104B	Homo sapiens	194-199
15917220-4	2005	FBI-1 enhanced NF-kappaB-mediated transcription of E-selectin genes in HeLa cells upon phorbol 12-myristate 13-acetate stimulation and overcame gene repression by IkappaB alpha or IkappaB beta.	Tetradecanoylphorbol Acetate	87-118	nuclear factor kappa B subunit 1	Homo sapiens	15-24
15950941-5	2005	IL-20-mediated inhibition of PMA-induced angiogenesis occurs through the COX-2 regulatory pathway.	Tetradecanoylphorbol Acetate	29-32	interleukin 20	Homo sapiens	0-5
15950941-5	2005	IL-20-mediated inhibition of PMA-induced angiogenesis occurs through the COX-2 regulatory pathway.	Tetradecanoylphorbol Acetate	29-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
15937142-5	2005	Furthermore, phorbol 12-myristate 13-acetate/ionomycin treatment induced surface expression of Fas-L and TRAIL.	Tetradecanoylphorbol Acetate	13-44	TNF superfamily member 10	Homo sapiens	105-110
15978937-5	2005	Both p21WAF1/CIP1 mRNA and protein were upregulated 24 h post PMA treatment as demonstrated by ribonuclease protection assay and Western blotting, respectively.	Tetradecanoylphorbol Acetate	62-65	cyclin dependent kinase inhibitor 1A	Homo sapiens	13-17
15978937-8	2005	Additionally, our study demonstrates that PMA-induces the upregulation of p21 through a protein kinase C (PKC)-mediated ROS-dependent signaling mechanism involving MAP kinase activation.	Tetradecanoylphorbol Acetate	42-45	cyclin dependent kinase inhibitor 1A	Homo sapiens	74-77
16129032-1	2005	In order to investigate the potential of human ERMAP gene in erythroid cell differentiation, K562 cells were induced to erythroid lineage by Ara-C and to macrophage lineage by TPA, human ERMAP mRNA was detected by fluorescent quantitative PCR.	Tetradecanoylphorbol Acetate	176-179	erythroblast membrane associated protein (Scianna blood group)	Homo sapiens	187-192
15944151-7	2005	At low concentrations, chlorogenic acid decreased the phosphorylation of c-Jun NH2-terminal kinases, p38 kinase, and MAPK kinase 4 induced by UVB/12-O-tetradecanoylphorbol-13-acetate, yet higher doses were required to inhibit extracellular signal-regulated kinases.	Tetradecanoylphorbol Acetate	146-182	mitogen-activated protein kinase 14	Homo sapiens	101-104
15978263-8	2005	Activation of PKC with phorbol-12-myristate-13-acetate (PMA) simulated tachyphylaxis to AVP in E- only, effect blocked by the NO donor, SNP.	Tetradecanoylphorbol Acetate	23-54	arginine vasopressin	Homo sapiens	88-91
15978263-8	2005	Activation of PKC with phorbol-12-myristate-13-acetate (PMA) simulated tachyphylaxis to AVP in E- only, effect blocked by the NO donor, SNP.	Tetradecanoylphorbol Acetate	56-59	arginine vasopressin	Homo sapiens	88-91
15927719-7	2005	Involvement of the protein kinase C (PKC) was evidenced by the sensitivity of the inhibitory effect of Ang-(1-7) to calphostin C (6.32 x 10(-7) M) and the lack of additive effects when the cells were co-incubated with Ang-(1-7) and 3.2 x 10(-8) M PMA.	Tetradecanoylphorbol Acetate	247-250	angiopoietin 1	Canis lupus familiaris	103-111
15811958-3	2005	We demonstrated that indole-3-carbinol suppressed constitutive NF-kappaB activation and activation induced by tumor necrosis factor (TNF), interleukin-1beta (IL-1beta), phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide (LPS), and cigarette smoke; the suppression was not cell type specific, because activation was inhibited in myeloid, leukemia, and epithelial cells.	Tetradecanoylphorbol Acetate	169-200	nuclear factor kappa B subunit 1	Homo sapiens	63-72
15811958-3	2005	We demonstrated that indole-3-carbinol suppressed constitutive NF-kappaB activation and activation induced by tumor necrosis factor (TNF), interleukin-1beta (IL-1beta), phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide (LPS), and cigarette smoke; the suppression was not cell type specific, because activation was inhibited in myeloid, leukemia, and epithelial cells.	Tetradecanoylphorbol Acetate	202-205	tumor necrosis factor	Homo sapiens	110-131
16024613-7	2005	However, whereas treatment of MCF-7 cells with the phorbol ester phorbol-12-myristate 13-acetate also enhances ERRalpha activation of the TFF1 promoter reporter, it does not affect ERRalpha activity on its own promoter.	Tetradecanoylphorbol Acetate	65-96	estrogen related receptor alpha	Homo sapiens	111-119
16024613-7	2005	However, whereas treatment of MCF-7 cells with the phorbol ester phorbol-12-myristate 13-acetate also enhances ERRalpha activation of the TFF1 promoter reporter, it does not affect ERRalpha activity on its own promoter.	Tetradecanoylphorbol Acetate	65-96	trefoil factor 1	Homo sapiens	138-142
15824731-6	2005	Furthermore, activation of PKCdelta by TPA resulted in activation and nuclear translocation of ERalpha and in an increase of ER-dependent reporter gene expression.	Tetradecanoylphorbol Acetate	39-42	estrogen receptor 1	Homo sapiens	95-102
15824731-7	2005	Transfection and expression of the regulatory domain RDdelta of PKCdelta, which is inhibitory to PKCdelta, inhibited the TPA-induced ERalpha activation and translocation.	Tetradecanoylphorbol Acetate	121-124	estrogen receptor 1	Homo sapiens	133-140
16024603-5	2005	In response to the 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) mouse skin carcinogenesis protocol, K14-Pdcd4 mice showed significant reductions in papilloma formation, carcinoma incidence, and papilloma-to-carcinoma conversion frequency compared with wild-type mice.	Tetradecanoylphorbol Acetate	57-93	programmed cell death 4	Mus musculus	140-145
16024603-7	2005	Pdcd4 inhibited by 46% TPA-induced activator protein-1 (AP-1)-dependent transcription, an event required for tumorigenesis.	Tetradecanoylphorbol Acetate	23-26	programmed cell death 4	Mus musculus	0-5
15741241-5	2005	The addition of phorbol 12-myristate,13-acetate (PMA) and forskolin to hepatocytes increased Hal mRNA concentration by 100 and 40%, respectively.	Tetradecanoylphorbol Acetate	49-52	histidine ammonia lyase	Rattus norvegicus	93-96
16002725-5	2005	In contrast, PMA-induced adhesion to VCAM-1 was unaffected by deletion of the NPIY motif and only slightly impaired by deletion of NPKY.	Tetradecanoylphorbol Acetate	13-16	vascular cell adhesion molecule 1	Homo sapiens	37-43
15913800-4	2005	Flow cytometry was used to investigate sequential changes of IFN-gamma producing (Th1) and interleukin-4 producing (Th2) cells from whole blood samples after stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	175-178	interferon gamma	Homo sapiens	61-70
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	168-193	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
15910743-2	2005	AICAR inhibited IL-2 production in Jurkat T cells and peripheral blood lymphocytes activated with PMA plus ionomycin (PMA/Io) or with monoclonal anti-CD3 plus anti-CD28.	Tetradecanoylphorbol Acetate	98-101	interleukin 2	Homo sapiens	16-20
15910743-2	2005	AICAR inhibited IL-2 production in Jurkat T cells and peripheral blood lymphocytes activated with PMA plus ionomycin (PMA/Io) or with monoclonal anti-CD3 plus anti-CD28.	Tetradecanoylphorbol Acetate	118-121	interleukin 2	Homo sapiens	16-20
15910743-4	2005	We then showed that AICAR inhibited PMA/Io-induced IL-2 mRNA expression and IL-2 promoter activation.	Tetradecanoylphorbol Acetate	36-39	interleukin 2	Homo sapiens	51-55
15910743-4	2005	We then showed that AICAR inhibited PMA/Io-induced IL-2 mRNA expression and IL-2 promoter activation.	Tetradecanoylphorbol Acetate	36-39	interleukin 2	Homo sapiens	76-80
15949478-5	2005	METHODS AND RESULTS: Downregulation of PKC by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis, the activation of MAPK, and the expression of c-myc, demonstrating the involvement of PMA-sensitive PKC isoforms in growth factor-induced proliferation and the MAPK pathway.	Tetradecanoylphorbol Acetate	46-77	fibroblast growth factor 2	Homo sapiens	94-98
15949478-5	2005	METHODS AND RESULTS: Downregulation of PKC by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis, the activation of MAPK, and the expression of c-myc, demonstrating the involvement of PMA-sensitive PKC isoforms in growth factor-induced proliferation and the MAPK pathway.	Tetradecanoylphorbol Acetate	79-82	fibroblast growth factor 2	Homo sapiens	94-98
15855253-4	2005	Intracellular expression of IFNgamma and IL-4 was evaluated by multicolor flow-cytometry analysis in peripheral lymphocytes in vitro stimulated by phorbol-12-myristate-13-acetate (PMA) (25 ng/ml) and ionomycin (1 mug/ml) in presence of monensin (5 microm).	Tetradecanoylphorbol Acetate	147-178	interferon gamma	Homo sapiens	28-36
15855253-4	2005	Intracellular expression of IFNgamma and IL-4 was evaluated by multicolor flow-cytometry analysis in peripheral lymphocytes in vitro stimulated by phorbol-12-myristate-13-acetate (PMA) (25 ng/ml) and ionomycin (1 mug/ml) in presence of monensin (5 microm).	Tetradecanoylphorbol Acetate	147-178	interleukin 4	Homo sapiens	41-45
15855253-4	2005	Intracellular expression of IFNgamma and IL-4 was evaluated by multicolor flow-cytometry analysis in peripheral lymphocytes in vitro stimulated by phorbol-12-myristate-13-acetate (PMA) (25 ng/ml) and ionomycin (1 mug/ml) in presence of monensin (5 microm).	Tetradecanoylphorbol Acetate	180-183	interferon gamma	Homo sapiens	28-36
15855253-4	2005	Intracellular expression of IFNgamma and IL-4 was evaluated by multicolor flow-cytometry analysis in peripheral lymphocytes in vitro stimulated by phorbol-12-myristate-13-acetate (PMA) (25 ng/ml) and ionomycin (1 mug/ml) in presence of monensin (5 microm).	Tetradecanoylphorbol Acetate	180-183	interleukin 4	Homo sapiens	41-45
15798003-8	2005	In contrast, when HUVECs were treated with phorbol 12-myristate 13-acetate, a PKC activator, we observed a significant increase in Snn gene expression.	Tetradecanoylphorbol Acetate	43-74	proline rich transmembrane protein 2	Homo sapiens	78-81
15908253-7	2005	Non-specific stimulation with PMA and ionomycin revealed increased frequencies of CD4+ cells expressing IFN-gamma in controls, while expression of IL-2, IL-4, IL-10, IL-13, and TNF-alpha was not different.	Tetradecanoylphorbol Acetate	30-33	CD4 molecule	Homo sapiens	82-85
15908253-7	2005	Non-specific stimulation with PMA and ionomycin revealed increased frequencies of CD4+ cells expressing IFN-gamma in controls, while expression of IL-2, IL-4, IL-10, IL-13, and TNF-alpha was not different.	Tetradecanoylphorbol Acetate	30-33	interferon gamma	Homo sapiens	104-113
15802498-5	2005	Furthermore, incubation of palmitate-treated cells with calphostin C, a strong and specific inhibitor of protein kinase C, and phorbol myristate acetate, that down-regulates protein kinase C in long-term incubations, abolished induction of IL-6 production.	Tetradecanoylphorbol Acetate	127-152	interleukin 6	Mus musculus	240-244
15622522-6	2005	TPA induced loss of function concomitant with a dislocation of ZO-1 and occludin could be prevented by inhibition of MEK1 by PD98059.	Tetradecanoylphorbol Acetate	0-3	tight junction protein 1	Homo sapiens	63-67
15888452-4	2005	Treatment with epidermal growth factor (EGF) failed to activate the ERK pathway in mitotic cells, although partial activation of ERK could be achieved in mitotic cells treated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	181-212	mitogen-activated protein kinase 1	Homo sapiens	129-132
15888452-4	2005	Treatment with epidermal growth factor (EGF) failed to activate the ERK pathway in mitotic cells, although partial activation of ERK could be achieved in mitotic cells treated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	214-217	mitogen-activated protein kinase 1	Homo sapiens	129-132
16117614-5	2005	To explain the apoptotic effects of SNL glycoprotein, we investigated its effects on 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated protein kinase C (PKC) alpha activity and DNA-binding activity of nuclear factor (NF) kappaB in HT-29 cells, using western blot analysis and electrophoretic mobility shift assays.	Tetradecanoylphorbol Acetate	85-121	protein kinase C alpha	Homo sapiens	157-160
16117614-5	2005	To explain the apoptotic effects of SNL glycoprotein, we investigated its effects on 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated protein kinase C (PKC) alpha activity and DNA-binding activity of nuclear factor (NF) kappaB in HT-29 cells, using western blot analysis and electrophoretic mobility shift assays.	Tetradecanoylphorbol Acetate	123-126	protein kinase C alpha	Homo sapiens	157-160
16117614-6	2005	Results from these experiments showed that SNL glycoprotein has remarkable inhibitory effects on the activities of TPA (100 nM)-stimulated PKCalpha and NF-kappaB in HT-29 cells.	Tetradecanoylphorbol Acetate	115-118	protein kinase C alpha	Homo sapiens	139-147
16117614-7	2005	They also substantiated that PKCalpha is a part of the TPA-activated upstream signal pathway of NF-kappaB, since NF-kappaB activity was inhibited by staurosporine (a PKC inhibitor) and pyrrolidine dithiocarbamate (an NF-kappaB inhibitor) in a western blot analysis.	Tetradecanoylphorbol Acetate	55-58	protein kinase C alpha	Homo sapiens	29-37
16117614-7	2005	They also substantiated that PKCalpha is a part of the TPA-activated upstream signal pathway of NF-kappaB, since NF-kappaB activity was inhibited by staurosporine (a PKC inhibitor) and pyrrolidine dithiocarbamate (an NF-kappaB inhibitor) in a western blot analysis.	Tetradecanoylphorbol Acetate	55-58	protein kinase C alpha	Homo sapiens	29-32
15920718-6	2005	Reverse transcriptase (RT)-polymerase chain reactions (PCR) detected fully-processed MRP/plf-mRNA 16-48 h after TPA treatments in five of six animals, and in three of six BPO-treated animals.	Tetradecanoylphorbol Acetate	112-115	melanoma antigen	Mus musculus	0-21
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	168-193	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	168-193	tumor necrosis factor	Homo sapiens	134-143
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	195-198	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	195-198	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	195-198	tumor necrosis factor	Homo sapiens	134-143
15824103-2	2005	The activity of other Nox enzymes such as gp91(phox)/Nox2 and Nox1 is known to absolutely require both an organizer protein (p47(phox) or Noxo1) andanactivatorprotein (p67(phox) or Noxa1); for the p47(phox)-dependent activation of these oxidases, treatment of cells with stimulants such as phorbol 12-myristate 13-acetate is also indispensable.	Tetradecanoylphorbol Acetate	290-321	NSFL1 (p97) cofactor (p47)	Mus musculus	47-51
15824103-2	2005	The activity of other Nox enzymes such as gp91(phox)/Nox2 and Nox1 is known to absolutely require both an organizer protein (p47(phox) or Noxo1) andanactivatorprotein (p67(phox) or Noxa1); for the p47(phox)-dependent activation of these oxidases, treatment of cells with stimulants such as phorbol 12-myristate 13-acetate is also indispensable.	Tetradecanoylphorbol Acetate	290-321	NSFL1 (p97) cofactor (p47)	Mus musculus	125-128
15806162-8	2005	However, in association with the -318 TRE, the SRE and ATF sites imparted a strong TPA-inducibility to the reporter.	Tetradecanoylphorbol Acetate	83-86	glial cell derived neurotrophic factor	Homo sapiens	55-58
15910736-4	2005	Expression experiments using mitogen-activated protein kinase phosphatase-1 or a dominant-negative mutant of the ternary complex factor Elk-1 revealed that the distal cluster of serum response elements is essential in the TPA-induced enhancement of Egr-1 promoter activity, encompassing two independent TPA-responsive elements.	Tetradecanoylphorbol Acetate	222-225	dual specificity phosphatase 1	Homo sapiens	29-75
15878157-8	2005	Phorbol ester 12-O-teradecanoyl-phorbol-13-acetate (TPA) activated AP-1 in B82L and B82M721 cells, but not B82 cells.	Tetradecanoylphorbol Acetate	52-55	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	67-71
15878157-9	2005	TPA-induced activation of ERK and PKCdelta was dependent on the expression of EGFR although the intrinsic kinase activity of EGFR was not required.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor receptor	Homo sapiens	78-82
15878157-9	2005	TPA-induced activation of ERK and PKCdelta was dependent on the expression of EGFR although the intrinsic kinase activity of EGFR was not required.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor receptor	Homo sapiens	125-129
15878157-10	2005	In contrast, TPA-induced phosphorylation of p38 MAPK, JNKs and other PKC isoforms was independent of EGFR.	Tetradecanoylphorbol Acetate	13-16	epidermal growth factor receptor	Homo sapiens	101-105
15878157-11	2005	Ethanol selectively inhibited TPA-induced phosphorylation of ERK and PKCdelta, and modestly suppressed TPA-stimulated AP-1 activation in B82L and B82M721 cells.	Tetradecanoylphorbol Acetate	103-106	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-122
15746434-3	2005	We found that the IL-8 mRNA expression in lung cancer cells significantly increased after coculture with phorbol myristate acetate-treated THP-1 cells and human primary lung macrophages.	Tetradecanoylphorbol Acetate	105-130	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
16037256-3	2005	As presented here, the stimulation of cultured monocytes by phorbol-12-myristate-13-acetate (TPA), an activator of protein kinase C that can mimic the effects of high glucose, angiotensin II, and other physiological stimuli, leads to cellular ROS generation and concomitant formation of intracellular CML.	Tetradecanoylphorbol Acetate	60-91	angiotensinogen	Homo sapiens	176-190
16037256-3	2005	As presented here, the stimulation of cultured monocytes by phorbol-12-myristate-13-acetate (TPA), an activator of protein kinase C that can mimic the effects of high glucose, angiotensin II, and other physiological stimuli, leads to cellular ROS generation and concomitant formation of intracellular CML.	Tetradecanoylphorbol Acetate	93-96	angiotensinogen	Homo sapiens	176-190
15786489-8	2005	Culture with dibutyryl cyclic AMP (DcAMP, 10(-5) or 10(-4) M) or phorbol 12-myristate 13-acetate (PMA, 10(-6) M), an activator of protein kinase C, caused a significant increase in regucalcin mRNA expression.	Tetradecanoylphorbol Acetate	65-96	regucalcin	Rattus norvegicus	181-191
15968830-3	2005	Judging by the cytokine production of interleukin-2 and interferon-gamma in peripheral blood mononuclear cells stimulated by phorbol-myristate-acetate (PMA) and ionomycin, immunosuppressive drugs given for rheumatic disorders during pregnancy do not induce significant immunosuppression in babies.	Tetradecanoylphorbol Acetate	125-150	interleukin 2	Homo sapiens	38-51
15968830-3	2005	Judging by the cytokine production of interleukin-2 and interferon-gamma in peripheral blood mononuclear cells stimulated by phorbol-myristate-acetate (PMA) and ionomycin, immunosuppressive drugs given for rheumatic disorders during pregnancy do not induce significant immunosuppression in babies.	Tetradecanoylphorbol Acetate	125-150	interferon gamma	Homo sapiens	56-72
15968830-3	2005	Judging by the cytokine production of interleukin-2 and interferon-gamma in peripheral blood mononuclear cells stimulated by phorbol-myristate-acetate (PMA) and ionomycin, immunosuppressive drugs given for rheumatic disorders during pregnancy do not induce significant immunosuppression in babies.	Tetradecanoylphorbol Acetate	152-155	interleukin 2	Homo sapiens	38-51
15968830-3	2005	Judging by the cytokine production of interleukin-2 and interferon-gamma in peripheral blood mononuclear cells stimulated by phorbol-myristate-acetate (PMA) and ionomycin, immunosuppressive drugs given for rheumatic disorders during pregnancy do not induce significant immunosuppression in babies.	Tetradecanoylphorbol Acetate	152-155	interferon gamma	Homo sapiens	56-72
15760920-3	2005	They mediated both the phorbol myristate acetate (PMA) downregulation of DMBT1 expression and the initiation of cell differentiation, which was measured by cell cycle withdrawal and the induction of the tissue-specific marker trefoil factor 1 (TFF1).	Tetradecanoylphorbol Acetate	23-48	trefoil factor 1	Homo sapiens	244-248
15760920-3	2005	They mediated both the phorbol myristate acetate (PMA) downregulation of DMBT1 expression and the initiation of cell differentiation, which was measured by cell cycle withdrawal and the induction of the tissue-specific marker trefoil factor 1 (TFF1).	Tetradecanoylphorbol Acetate	50-53	trefoil factor 1	Homo sapiens	244-248
15969673-9	2005	Furthermore, phorbol-12-myristate-13-acetate and calcium ionophore stimulated the release of IL-4 after 48 h treatment in the presence of anti-IL-4 receptor antibody.	Tetradecanoylphorbol Acetate	13-44	interleukin 4	Homo sapiens	93-97
15969673-9	2005	Furthermore, phorbol-12-myristate-13-acetate and calcium ionophore stimulated the release of IL-4 after 48 h treatment in the presence of anti-IL-4 receptor antibody.	Tetradecanoylphorbol Acetate	13-44	interleukin 4	Homo sapiens	143-147
15944195-5	2005	Both B7 and DC-SIGN co-stimulated phorbol myristate acetate-stimulated CD4+ cells as compared with controls.	Tetradecanoylphorbol Acetate	34-59	CD4 molecule	Homo sapiens	71-74
15905586-4	2005	We found that ACA suppressed NF-kappaB activation induced by a wide variety of inflammatory and carcinogenic agents, including TNF, IL-1beta, PMA, LPS, H(2)O(2), doxorubicin, and cigarette smoke condensate.	Tetradecanoylphorbol Acetate	142-145	nuclear factor kappa B subunit 1	Homo sapiens	29-38
15774549-3	2005	Pretreatment of splenocytes with 2-AG markedly suppressed phorbol 12-myristate 13-acetate plus calcium ionophore (PMA/Io)-induced IFN-gamma secretion.	Tetradecanoylphorbol Acetate	58-89	interferon gamma	Mus musculus	130-139
15934948-5	2005	CXCL16 is continuously released from glial cells by proteolytic cleavage which is rapidly enhanced by stimulation with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	119-150	C-X-C motif chemokine ligand 16	Homo sapiens	0-6
15934948-5	2005	CXCL16 is continuously released from glial cells by proteolytic cleavage which is rapidly enhanced by stimulation with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	152-155	C-X-C motif chemokine ligand 16	Homo sapiens	0-6
15823586-8	2005	These findings suggest that PKCalpha is involved in TPA-mediated stabilization of p14(ARF) protein, and this effect of TPA was not affected by the Ras/MAPK pathway or p53 status.	Tetradecanoylphorbol Acetate	119-122	cyclin dependent kinase inhibitor 2A	Homo sapiens	82-85
15823586-0	2005	PKCalpha is involved in phorbol ester TPA-mediated stabilization of p14ARF.	Tetradecanoylphorbol Acetate	38-41	protein kinase C alpha	Homo sapiens	0-8
15774771-3	2005	Treatment of rat platelets with beta-phorbol 12-myristate 13-acetate (PMA) for 5 min or less resulted in a rapid inhibition of SERT involving changes in intrinsic activity of the transporter (increased K(m) and decreased V(max)).	Tetradecanoylphorbol Acetate	32-68	solute carrier family 6 member 4	Rattus norvegicus	127-131
15774771-3	2005	Treatment of rat platelets with beta-phorbol 12-myristate 13-acetate (PMA) for 5 min or less resulted in a rapid inhibition of SERT involving changes in intrinsic activity of the transporter (increased K(m) and decreased V(max)).	Tetradecanoylphorbol Acetate	70-73	solute carrier family 6 member 4	Rattus norvegicus	127-131
15899818-5	2005	To address the putative mechanisms that underlie resistance to PKC/p53-induced cell death, we generated a phorbol 12-myristate 13-acetate/p53-resistant SW480 subline and compared the gene expression profile of resistant and parental cells by DNA microarray analysis.	Tetradecanoylphorbol Acetate	106-137	tumor protein p53	Homo sapiens	67-70
15770664-5	2005	Unlike K562 cells, JURL-MK1 cells possess a probably functional p53 protein inducible by TPA (tetradecanoyl phorbol acetate) or UV-B irradiation.	Tetradecanoylphorbol Acetate	89-92	tumor protein p53	Homo sapiens	64-67
15770664-5	2005	Unlike K562 cells, JURL-MK1 cells possess a probably functional p53 protein inducible by TPA (tetradecanoyl phorbol acetate) or UV-B irradiation.	Tetradecanoylphorbol Acetate	94-123	tumor protein p53	Homo sapiens	64-67
15823586-0	2005	PKCalpha is involved in phorbol ester TPA-mediated stabilization of p14ARF.	Tetradecanoylphorbol Acetate	38-41	cyclin dependent kinase inhibitor 2A	Homo sapiens	68-74
15823586-4	2005	We found that phorbol ester TPA (12-o-tetradecanoyl-phorbol 13-acetate) stabilized p14(ARF) protein and that p53 status had no effect on TPA-mediated stabilization.	Tetradecanoylphorbol Acetate	28-31	cyclin dependent kinase inhibitor 2A	Homo sapiens	83-86
15823586-4	2005	We found that phorbol ester TPA (12-o-tetradecanoyl-phorbol 13-acetate) stabilized p14(ARF) protein and that p53 status had no effect on TPA-mediated stabilization.	Tetradecanoylphorbol Acetate	33-70	cyclin dependent kinase inhibitor 2A	Homo sapiens	83-86
15823586-6	2005	We further investigated which isoforms of PKC were involved in TPA-mediated p14(ARF) stabilization using short-interference RNA.	Tetradecanoylphorbol Acetate	63-66	protein kinase C alpha	Homo sapiens	42-45
15823586-6	2005	We further investigated which isoforms of PKC were involved in TPA-mediated p14(ARF) stabilization using short-interference RNA.	Tetradecanoylphorbol Acetate	63-66	cyclin dependent kinase inhibitor 2A	Homo sapiens	76-79
15823586-7	2005	Knockdown of PKCalpha, but not PKCdelta, attenuated TPA-mediated p14(ARF) stabilization.	Tetradecanoylphorbol Acetate	52-55	protein kinase C alpha	Homo sapiens	13-21
15823586-7	2005	Knockdown of PKCalpha, but not PKCdelta, attenuated TPA-mediated p14(ARF) stabilization.	Tetradecanoylphorbol Acetate	52-55	cyclin dependent kinase inhibitor 2A	Homo sapiens	65-68
15823586-8	2005	These findings suggest that PKCalpha is involved in TPA-mediated stabilization of p14(ARF) protein, and this effect of TPA was not affected by the Ras/MAPK pathway or p53 status.	Tetradecanoylphorbol Acetate	52-55	protein kinase C alpha	Homo sapiens	28-36
15823586-8	2005	These findings suggest that PKCalpha is involved in TPA-mediated stabilization of p14(ARF) protein, and this effect of TPA was not affected by the Ras/MAPK pathway or p53 status.	Tetradecanoylphorbol Acetate	52-55	cyclin dependent kinase inhibitor 2A	Homo sapiens	82-85
15904490-5	2005	After 24 hours of PMA-induced monocyte differentiation, the mean fluorescence intensity of CD147 in differentiated THP-1 cells (289.61 +/- 31.63) was higher than that of the undifferentiated THP-1 cells (205.1 +/- 19.25).	Tetradecanoylphorbol Acetate	18-21	GLI family zinc finger 2	Homo sapiens	115-120
15904490-5	2005	After 24 hours of PMA-induced monocyte differentiation, the mean fluorescence intensity of CD147 in differentiated THP-1 cells (289.61 +/- 31.63) was higher than that of the undifferentiated THP-1 cells (205.1 +/- 19.25).	Tetradecanoylphorbol Acetate	18-21	GLI family zinc finger 2	Homo sapiens	191-196
15855058-8	2005	Inhibition of PKCalpha in isolated TII cells by long-time incubation with PMA inhibited PKCalpha and Prx-1 but not Prx-6.	Tetradecanoylphorbol Acetate	74-77	paired related homeobox 1	Rattus norvegicus	101-106
15743775-8	2005	L-PGDS expression was induced by 12-O-tetradecanoylphorbol-13-acetate in TE671 cells, and this induction was inhibited by a protein kinase C inhibitor.	Tetradecanoylphorbol Acetate	33-69	prostaglandin D2 synthase	Homo sapiens	0-6
15757899-4	2005	Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.	Tetradecanoylphorbol Acetate	63-66	proline rich transmembrane protein 2	Homo sapiens	18-34
15757899-4	2005	Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.	Tetradecanoylphorbol Acetate	63-66	proline rich transmembrane protein 2	Homo sapiens	36-39
15757899-4	2005	Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.	Tetradecanoylphorbol Acetate	63-66	nuclear factor kappa B subunit 1	Homo sapiens	112-122
15757899-4	2005	Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.	Tetradecanoylphorbol Acetate	63-66	mitogen-activated protein kinase 14	Homo sapiens	182-185
15757899-4	2005	Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.	Tetradecanoylphorbol Acetate	63-66	mitogen-activated protein kinase kinase 7	Homo sapiens	192-195
15757899-4	2005	Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.	Tetradecanoylphorbol Acetate	63-66	nuclear factor kappa B subunit 1	Homo sapiens	251-261
15757899-4	2005	Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.	Tetradecanoylphorbol Acetate	222-225	proline rich transmembrane protein 2	Homo sapiens	18-34
15757899-4	2005	Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.	Tetradecanoylphorbol Acetate	222-225	proline rich transmembrane protein 2	Homo sapiens	36-39
15757899-8	2005	These results demonstrate that NAG-1 expression is up-regulated by TPA in LNCaP cells through a PKC-dependent pathway involving the activation of NF-kappa B.	Tetradecanoylphorbol Acetate	67-70	proline rich transmembrane protein 2	Homo sapiens	96-99
15749716-0	2005	Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear.	Tetradecanoylphorbol Acetate	113-149	cannabinoid receptor 2 (macrophage)	Mus musculus	48-51
15749716-5	2005	In this study, we investigated possible pathophysiological roles of the CB2 receptor and 2-arachidonoylglycerol in acute inflammation in mouse ear induced by the topical application of 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	185-221	cannabinoid receptor 2 (macrophage)	Mus musculus	72-75
15743775-9	2005	Stimulation of TE671 cells with 12-O-tetradecanoylphorbol-13-acetate or transfection with protein kinase Calpha expression vector induced phosphorylation of Hes-1, inhibition of DNA binding of Hes-1 to the N-box, and activation of the AP-2beta function to up-regulate L-PGDS gene expression.	Tetradecanoylphorbol Acetate	32-68	prostaglandin D2 synthase	Homo sapiens	268-274
15749716-8	2005	Importantly, 12-O-tetradecanoylphorbol-13-acetate-induced ear swelling was blocked by treatment with SR144528, a CB2 receptor antagonist, suggesting that the CB2 receptor is involved in the swelling.	Tetradecanoylphorbol Acetate	13-49	cannabinoid receptor 2 (macrophage)	Mus musculus	113-116
15749716-8	2005	Importantly, 12-O-tetradecanoylphorbol-13-acetate-induced ear swelling was blocked by treatment with SR144528, a CB2 receptor antagonist, suggesting that the CB2 receptor is involved in the swelling.	Tetradecanoylphorbol Acetate	13-49	cannabinoid receptor 2 (macrophage)	Mus musculus	158-161
15625302-1	2005	We have previously demonstrated that constant 20 mmHg extracellular pressure increases serum-opsonized latex bead phagocytosis by phorbol 12-myristate 13-acetate (PMA)- differentiated THP-1 macrophages in part by inhibiting focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	130-161	GLI family zinc finger 2	Homo sapiens	184-189
15625302-1	2005	We have previously demonstrated that constant 20 mmHg extracellular pressure increases serum-opsonized latex bead phagocytosis by phorbol 12-myristate 13-acetate (PMA)- differentiated THP-1 macrophages in part by inhibiting focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	163-166	GLI family zinc finger 2	Homo sapiens	184-189
15974445-2	2005	In the present study, lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate/phytohemagglutinin (PMA/PHA) were used as stimulants for RAW 264.7 macrophages and human peripheral blood mononuclear cell (hPBMC), and tumor necrosis factor (TNF)-alpha and interleukin (IL)-2 productions were measured.	Tetradecanoylphorbol Acetate	51-82	tumor necrosis factor	Homo sapiens	219-252
15625302-1	2005	We have previously demonstrated that constant 20 mmHg extracellular pressure increases serum-opsonized latex bead phagocytosis by phorbol 12-myristate 13-acetate (PMA)- differentiated THP-1 macrophages in part by inhibiting focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	163-166	mitogen-activated protein kinase 1	Homo sapiens	256-293
15625302-1	2005	We have previously demonstrated that constant 20 mmHg extracellular pressure increases serum-opsonized latex bead phagocytosis by phorbol 12-myristate 13-acetate (PMA)- differentiated THP-1 macrophages in part by inhibiting focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	163-166	mitogen-activated protein kinase 1	Homo sapiens	295-298
15974445-2	2005	In the present study, lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate/phytohemagglutinin (PMA/PHA) were used as stimulants for RAW 264.7 macrophages and human peripheral blood mononuclear cell (hPBMC), and tumor necrosis factor (TNF)-alpha and interleukin (IL)-2 productions were measured.	Tetradecanoylphorbol Acetate	51-82	interleukin 2	Homo sapiens	257-275
15928807-2	2005	To clarify the role of AR in tumor cells, we investigated the pathways mediating expression of the AR gene induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter.	Tetradecanoylphorbol Acetate	118-154	aldo-keto reductase family 1 member B	Homo sapiens	99-101
15867370-3	2005	Herein, we show that p53 translocation to mitochondria precedes its translocation to nucleus in JB6 skin epidermal cells treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	153-189	tumor protein p53	Homo sapiens	21-24
15867370-3	2005	Herein, we show that p53 translocation to mitochondria precedes its translocation to nucleus in JB6 skin epidermal cells treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	191-194	tumor protein p53	Homo sapiens	21-24
15867370-4	2005	Translocation of p53 to mitochondria occurs within 10 minutes after TPA application.	Tetradecanoylphorbol Acetate	68-71	tumor protein p53	Homo sapiens	17-20
15928807-2	2005	To clarify the role of AR in tumor cells, we investigated the pathways mediating expression of the AR gene induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter.	Tetradecanoylphorbol Acetate	156-159	aldo-keto reductase family 1 member B	Homo sapiens	99-101
15867370-6	2005	In contrast to the immediate action on mitochondria, p53 transcriptional activity in the nucleus increases at 1 hour following TPA application, accompanied by an increase in the levels of its target gene bax at 15 hours following TPA treatment.	Tetradecanoylphorbol Acetate	127-130	tumor protein p53	Homo sapiens	53-56
15928807-3	2005	In A549 human lung adenocarcinoma cells, TPA elicited a dose- and time-dependent increase in AR mRNA level with an elevated enzyme activity.	Tetradecanoylphorbol Acetate	41-44	aldo-keto reductase family 1 member B	Homo sapiens	93-95
15867370-6	2005	In contrast to the immediate action on mitochondria, p53 transcriptional activity in the nucleus increases at 1 hour following TPA application, accompanied by an increase in the levels of its target gene bax at 15 hours following TPA treatment.	Tetradecanoylphorbol Acetate	230-233	tumor protein p53	Homo sapiens	53-56
15928807-4	2005	The TPA-induced increase in mRNA level and promoter activity of the AR gene was significantly attenuated in the presence of an inhibitor of protein kinase C, tyrosine kinase, or nuclear factor kappaB (NF-kappaB).	Tetradecanoylphorbol Acetate	4-7	aldo-keto reductase family 1 member B	Homo sapiens	68-70
15867378-7	2005	In addition, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcriptional activity of wild-type MMP-3 promoter was 10-fold higher than the mutants activity.	Tetradecanoylphorbol Acetate	13-49	matrix metallopeptidase 3	Homo sapiens	102-107
15867378-7	2005	In addition, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcriptional activity of wild-type MMP-3 promoter was 10-fold higher than the mutants activity.	Tetradecanoylphorbol Acetate	51-54	matrix metallopeptidase 3	Homo sapiens	102-107
15928807-4	2005	The TPA-induced increase in mRNA level and promoter activity of the AR gene was significantly attenuated in the presence of an inhibitor of protein kinase C, tyrosine kinase, or nuclear factor kappaB (NF-kappaB).	Tetradecanoylphorbol Acetate	4-7	nuclear factor kappa B subunit 1	Homo sapiens	193-199
15867378-9	2005	Significantly, dexamethasone almost completely blunted the TPA-induced effect on wild-type MMP-3 promoter transcriptional activity and on the mutants, even below their basal activity.	Tetradecanoylphorbol Acetate	59-62	matrix metallopeptidase 3	Homo sapiens	91-96
15928807-4	2005	The TPA-induced increase in mRNA level and promoter activity of the AR gene was significantly attenuated in the presence of an inhibitor of protein kinase C, tyrosine kinase, or nuclear factor kappaB (NF-kappaB).	Tetradecanoylphorbol Acetate	4-7	nuclear factor kappa B subunit 1	Homo sapiens	201-210
15928807-5	2005	TPA augmented the NF-kappaB-dependent gene transcription, indicating the involvement of NF-kappaB in this regulation.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	18-27
15928807-5	2005	TPA augmented the NF-kappaB-dependent gene transcription, indicating the involvement of NF-kappaB in this regulation.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	88-97
15928807-6	2005	Accumulation of TPA-treated cells in S phase was almost completely abolished in the presence of ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, an AR inhibitor.	Tetradecanoylphorbol Acetate	16-19	aldo-keto reductase family 1 member B	Homo sapiens	156-158
15928807-7	2005	Taken together, TPA augmented the promoter activity of the AR gene via the activation of protein kinase and NF-kappaB.	Tetradecanoylphorbol Acetate	16-19	aldo-keto reductase family 1 member B	Homo sapiens	59-61
15928807-7	2005	Taken together, TPA augmented the promoter activity of the AR gene via the activation of protein kinase and NF-kappaB.	Tetradecanoylphorbol Acetate	16-19	nuclear factor kappa B subunit 1	Homo sapiens	108-117
15868610-10	2005	MTX reduced the levels of IL-6 induced by 12-O-tetradecanoylphorbol 13-acetate, a direct activator of protein kinase C (PKC), suggesting that MTX inhibits PKC signals for IL-6 synthesis.	Tetradecanoylphorbol Acetate	42-78	interleukin 6	Mus musculus	26-30
15868610-10	2005	MTX reduced the levels of IL-6 induced by 12-O-tetradecanoylphorbol 13-acetate, a direct activator of protein kinase C (PKC), suggesting that MTX inhibits PKC signals for IL-6 synthesis.	Tetradecanoylphorbol Acetate	42-78	interleukin 6	Mus musculus	171-175
15626739-9	2005	Consequently, Nef activation caused the inhibition of M-CSF-mediated proliferation of TF-1-fms cells and macrophage differentiation of the cells induced by M-CSF and 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	166-202	S100 calcium binding protein B	Homo sapiens	14-17
15897236-9	2005	Pharmacologic PKCalpha "knockdown" abrogated TPA-induced Erk1/2 activation without affecting the EGF/EGFR-induced response, indicating that PKCalpha was required for EGFR transactivation but dispensable for signaling of ligand-activated EGFR to Erk1/2 activation.	Tetradecanoylphorbol Acetate	45-48	protein kinase C alpha	Homo sapiens	14-22
15897236-9	2005	Pharmacologic PKCalpha "knockdown" abrogated TPA-induced Erk1/2 activation without affecting the EGF/EGFR-induced response, indicating that PKCalpha was required for EGFR transactivation but dispensable for signaling of ligand-activated EGFR to Erk1/2 activation.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase 3	Homo sapiens	57-63
15897236-9	2005	Pharmacologic PKCalpha "knockdown" abrogated TPA-induced Erk1/2 activation without affecting the EGF/EGFR-induced response, indicating that PKCalpha was required for EGFR transactivation but dispensable for signaling of ligand-activated EGFR to Erk1/2 activation.	Tetradecanoylphorbol Acetate	45-48	protein kinase C alpha	Homo sapiens	140-148
15897236-9	2005	Pharmacologic PKCalpha "knockdown" abrogated TPA-induced Erk1/2 activation without affecting the EGF/EGFR-induced response, indicating that PKCalpha was required for EGFR transactivation but dispensable for signaling of ligand-activated EGFR to Erk1/2 activation.	Tetradecanoylphorbol Acetate	45-48	epidermal growth factor receptor	Homo sapiens	166-170
15897236-9	2005	Pharmacologic PKCalpha "knockdown" abrogated TPA-induced Erk1/2 activation without affecting the EGF/EGFR-induced response, indicating that PKCalpha was required for EGFR transactivation but dispensable for signaling of ligand-activated EGFR to Erk1/2 activation.	Tetradecanoylphorbol Acetate	45-48	epidermal growth factor receptor	Homo sapiens	166-170
15897236-9	2005	Pharmacologic PKCalpha "knockdown" abrogated TPA-induced Erk1/2 activation without affecting the EGF/EGFR-induced response, indicating that PKCalpha was required for EGFR transactivation but dispensable for signaling of ligand-activated EGFR to Erk1/2 activation.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase 3	Homo sapiens	245-251
15897236-10	2005	We corroborated this by showing that Go6976, which is a PKCalpha-selective inhibitor in PC-3 cells, likewise abolished TPA-induced Erk1/2 activation and did not inhibit EGF/EGFR-induced Erk1/2 activation.	Tetradecanoylphorbol Acetate	119-122	protein kinase C alpha	Homo sapiens	56-64
15897236-10	2005	We corroborated this by showing that Go6976, which is a PKCalpha-selective inhibitor in PC-3 cells, likewise abolished TPA-induced Erk1/2 activation and did not inhibit EGF/EGFR-induced Erk1/2 activation.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 3	Homo sapiens	131-137
15897236-10	2005	We corroborated this by showing that Go6976, which is a PKCalpha-selective inhibitor in PC-3 cells, likewise abolished TPA-induced Erk1/2 activation and did not inhibit EGF/EGFR-induced Erk1/2 activation.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 3	Homo sapiens	186-192
15931581-7	2005	Additionally, andrographolide and to a lesser extent 14-DAP, at doses of 50 microM and 100 microM, respectively, reduced the apoptosis induced by hydrocortisone and PMA in thymocytes, which was associated to a decrease in caspase-3 like activity.	Tetradecanoylphorbol Acetate	165-168	death-associated protein	Mus musculus	56-59
15830103-8	2005	To further clarify HTm4"s function in hematopoietic cell cycle regulation, K562 cells were treated with PMA.	Tetradecanoylphorbol Acetate	104-107	membrane spanning 4-domains A3	Homo sapiens	19-23
15826073-7	2005	Lingonberry extract also prevented TPA-induced phosphorylation of ERK1, ERK2, and MEK1/2.	Tetradecanoylphorbol Acetate	35-38	mitogen-activated protein kinase 3	Homo sapiens	66-70
15826073-7	2005	Lingonberry extract also prevented TPA-induced phosphorylation of ERK1, ERK2, and MEK1/2.	Tetradecanoylphorbol Acetate	35-38	mitogen-activated protein kinase 1	Homo sapiens	72-76
15897236-3	2005	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced Erk1/2 activation in human prostate cancer PC-3 cells is a paradigm of diacylglycerol-induced EGFR transactivation in androgen-independent prostate cancer.	Tetradecanoylphorbol Acetate	0-36	mitogen-activated protein kinase 3	Homo sapiens	51-57
15897236-3	2005	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced Erk1/2 activation in human prostate cancer PC-3 cells is a paradigm of diacylglycerol-induced EGFR transactivation in androgen-independent prostate cancer.	Tetradecanoylphorbol Acetate	0-36	epidermal growth factor receptor	Homo sapiens	145-149
15897236-3	2005	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced Erk1/2 activation in human prostate cancer PC-3 cells is a paradigm of diacylglycerol-induced EGFR transactivation in androgen-independent prostate cancer.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase 3	Homo sapiens	51-57
15897236-3	2005	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced Erk1/2 activation in human prostate cancer PC-3 cells is a paradigm of diacylglycerol-induced EGFR transactivation in androgen-independent prostate cancer.	Tetradecanoylphorbol Acetate	38-41	epidermal growth factor receptor	Homo sapiens	145-149
15897236-4	2005	In this report, we establish an obligatory role for TPA-induced protein kinase C (PKC)-alpha activation in EGFR transactivation and signaling to Erk1/2 activation in PC-3 cells.	Tetradecanoylphorbol Acetate	52-55	epidermal growth factor receptor	Homo sapiens	107-111
15897236-4	2005	In this report, we establish an obligatory role for TPA-induced protein kinase C (PKC)-alpha activation in EGFR transactivation and signaling to Erk1/2 activation in PC-3 cells.	Tetradecanoylphorbol Acetate	52-55	mitogen-activated protein kinase 3	Homo sapiens	145-151
15897236-6	2005	The PKC-selective inhibitors GF109203X and Go6983 each blocked TPA-induced EGFR transactivation, indicating a requirement for PKC.	Tetradecanoylphorbol Acetate	63-66	protein kinase C alpha	Homo sapiens	4-7
15897236-6	2005	The PKC-selective inhibitors GF109203X and Go6983 each blocked TPA-induced EGFR transactivation, indicating a requirement for PKC.	Tetradecanoylphorbol Acetate	63-66	epidermal growth factor receptor	Homo sapiens	75-79
15897236-6	2005	The PKC-selective inhibitors GF109203X and Go6983 each blocked TPA-induced EGFR transactivation, indicating a requirement for PKC.	Tetradecanoylphorbol Acetate	63-66	protein kinase C alpha	Homo sapiens	126-129
15862138-1	2005	AIM: To investigate the regulation of soluble and membrane bound TNF-related apoptosis-inducing ligand (TRAIL) in Jurkt cells by phorbol myristic acctate (PMA), and the cytotoxicity of the two forms of TRAIL.	Tetradecanoylphorbol Acetate	155-158	TNF superfamily member 10	Homo sapiens	65-102
15862138-1	2005	AIM: To investigate the regulation of soluble and membrane bound TNF-related apoptosis-inducing ligand (TRAIL) in Jurkt cells by phorbol myristic acctate (PMA), and the cytotoxicity of the two forms of TRAIL.	Tetradecanoylphorbol Acetate	155-158	TNF superfamily member 10	Homo sapiens	104-109
15759135-4	2005	TPA treatment induced epidermal acanthosis, which was more markedly suppressed by ATX-S10(Na) PDT than by ALA PDT.	Tetradecanoylphorbol Acetate	0-3	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	82-85
15843042-2	2005	In the present study, we found that 12-o-tetradecanoylphorbol 13-acetate (TPA) induced cyclooxygenase 2 (COX-2), but not COX-1, protein expression in HL-60 cells, and the addition of arachidonic acid (AA) in the presence or absence of TPA significantly reduced the viability of HL-60 cells, an effect that was blocked by adding the COX inhibitors, NS398 and aspirin.	Tetradecanoylphorbol Acetate	36-72	prostaglandin-endoperoxide synthase 2	Homo sapiens	87-103
15843042-2	2005	In the present study, we found that 12-o-tetradecanoylphorbol 13-acetate (TPA) induced cyclooxygenase 2 (COX-2), but not COX-1, protein expression in HL-60 cells, and the addition of arachidonic acid (AA) in the presence or absence of TPA significantly reduced the viability of HL-60 cells, an effect that was blocked by adding the COX inhibitors, NS398 and aspirin.	Tetradecanoylphorbol Acetate	36-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
15843042-2	2005	In the present study, we found that 12-o-tetradecanoylphorbol 13-acetate (TPA) induced cyclooxygenase 2 (COX-2), but not COX-1, protein expression in HL-60 cells, and the addition of arachidonic acid (AA) in the presence or absence of TPA significantly reduced the viability of HL-60 cells, an effect that was blocked by adding the COX inhibitors, NS398 and aspirin.	Tetradecanoylphorbol Acetate	74-77	prostaglandin-endoperoxide synthase 2	Homo sapiens	87-103
15843042-2	2005	In the present study, we found that 12-o-tetradecanoylphorbol 13-acetate (TPA) induced cyclooxygenase 2 (COX-2), but not COX-1, protein expression in HL-60 cells, and the addition of arachidonic acid (AA) in the presence or absence of TPA significantly reduced the viability of HL-60 cells, an effect that was blocked by adding the COX inhibitors, NS398 and aspirin.	Tetradecanoylphorbol Acetate	74-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
15777800-11	2005	In U1810 cells, Ro 31-8220 decreased PMA-induced ERK phosphorylation as efficiently as PKC 412, indicating that the failure of Ro 31-8220 to induce apoptosis was not due to weaker inhibition of conventional and novel PKC isoforms.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 1	Homo sapiens	49-52
15737651-2	2005	Using oligonucleotide microarray analysis, we have identified a novel gene that is upregulated following treatment with TPA in the pancreatic cancer cell line CD18.	Tetradecanoylphorbol Acetate	120-123	integrin subunit beta 2	Homo sapiens	159-163
15735738-5	2005	Since the transcription factor nuclear factor-kappaB (NF-kappaB) is known to regulate COX-2 induction, we attempted to determine the effect of [6]-gingerol on TPA-induced activation of NF-kappaB.	Tetradecanoylphorbol Acetate	159-162	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	31-52
15735738-5	2005	Since the transcription factor nuclear factor-kappaB (NF-kappaB) is known to regulate COX-2 induction, we attempted to determine the effect of [6]-gingerol on TPA-induced activation of NF-kappaB.	Tetradecanoylphorbol Acetate	159-162	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	54-63
15735738-5	2005	Since the transcription factor nuclear factor-kappaB (NF-kappaB) is known to regulate COX-2 induction, we attempted to determine the effect of [6]-gingerol on TPA-induced activation of NF-kappaB.	Tetradecanoylphorbol Acetate	159-162	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	185-194
15735738-6	2005	Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-kappaB through suppression of IkappaBalpha degradation and p65 nuclear translocation.	Tetradecanoylphorbol Acetate	62-65	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-129
15735738-6	2005	Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-kappaB through suppression of IkappaBalpha degradation and p65 nuclear translocation.	Tetradecanoylphorbol Acetate	62-65	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	153-165
15735738-8	2005	In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-kappaB.	Tetradecanoylphorbol Acetate	36-39	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	181-190
15735738-10	2005	The p38 MAP kinase inhibitor SB203580 attenuated NF-kappaB activation and subsequent COX-2 induction in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	104-107	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-58
15735738-11	2005	Taken together, our data suggest that [6]-gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-kappaB signaling pathway.	Tetradecanoylphorbol Acetate	60-63	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
15797241-0	2005	Repression of 5-aminolevulinate synthase gene by the potent tumor promoter, TPA, involves multiple signal transduction pathways.	Tetradecanoylphorbol Acetate	76-79	5'-aminolevulinate synthase 1	Homo sapiens	14-40
15797241-1	2005	The potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) induces activator protein-1 (AP-1) transcription factors, early response genes involved in a diverse set of transcriptional regulatory processes, and protein kinase C (PKC) activity.	Tetradecanoylphorbol Acetate	27-63	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	78-97
15797241-1	2005	The potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) induces activator protein-1 (AP-1) transcription factors, early response genes involved in a diverse set of transcriptional regulatory processes, and protein kinase C (PKC) activity.	Tetradecanoylphorbol Acetate	27-63	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	99-103
15797241-1	2005	The potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) induces activator protein-1 (AP-1) transcription factors, early response genes involved in a diverse set of transcriptional regulatory processes, and protein kinase C (PKC) activity.	Tetradecanoylphorbol Acetate	65-68	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	78-97
15797241-1	2005	The potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) induces activator protein-1 (AP-1) transcription factors, early response genes involved in a diverse set of transcriptional regulatory processes, and protein kinase C (PKC) activity.	Tetradecanoylphorbol Acetate	65-68	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	99-103
15797241-2	2005	This work was designed to explore the signal transduction pathways involved in TPA regulation of 5-aminolevulinate synthase (ALAS) gene expression, the mitochondrial matrix enzyme that catalyzes the first and rate-limiting step of heme biosynthesis.	Tetradecanoylphorbol Acetate	79-82	5'-aminolevulinate synthase 1	Homo sapiens	97-123
15797241-2	2005	This work was designed to explore the signal transduction pathways involved in TPA regulation of 5-aminolevulinate synthase (ALAS) gene expression, the mitochondrial matrix enzyme that catalyzes the first and rate-limiting step of heme biosynthesis.	Tetradecanoylphorbol Acetate	79-82	5'-aminolevulinate synthase 1	Homo sapiens	125-129
15797241-3	2005	We have previously reported that TPA causes repression of ALAS gene, but the signaling pathways mediating this effect remain elusive.	Tetradecanoylphorbol Acetate	33-36	5'-aminolevulinate synthase 1	Homo sapiens	58-62
15797241-6	2005	In these experimental conditions, we analyzed TPA action upon endogenous ALAS mRNA levels, as well as the promoter activity of a fusion reporter construct, harboring the TPA-responsive region of ALAS gene driving chloramphenicol acetyl transferase gene expression.	Tetradecanoylphorbol Acetate	170-173	5'-aminolevulinate synthase 1	Homo sapiens	195-199
15797241-10	2005	Furthermore, we elucidated the crosstalk among the components of the cascades taking part in TPA-mediated ALAS repression.	Tetradecanoylphorbol Acetate	93-96	5'-aminolevulinate synthase 1	Homo sapiens	106-110
15946602-12	2005	In addition, GBIT extract inhibited phorbol 12-myristate 13-acetate + A23187-induced interleukin-6 secretion from human mast cell line HMC-1 cells.	Tetradecanoylphorbol Acetate	36-67	interleukin 6	Homo sapiens	85-98
15849849-4	2005	In vitro IFN-gamma and IL-4 secretion by peripheral blood mononuclear cells after stimulation with ionomycin and phorbol 12 myristate 13 acetate was measured by enzyme-linked immunosorbent assay (ELISA) tests.	Tetradecanoylphorbol Acetate	113-144	interferon gamma	Homo sapiens	9-18
15721302-0	2005	Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2.	Tetradecanoylphorbol Acetate	14-45	mitogen-activated protein kinase kinase 7	Homo sapiens	118-121
15721302-0	2005	Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2.	Tetradecanoylphorbol Acetate	14-45	mitogen-activated protein kinase 3	Homo sapiens	148-154
15721302-5	2005	PMA induced activation of ERK1/2, but this effect was not prevented by the MEK inhibitors PD98059 or by U0126.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	26-32
15849849-4	2005	In vitro IFN-gamma and IL-4 secretion by peripheral blood mononuclear cells after stimulation with ionomycin and phorbol 12 myristate 13 acetate was measured by enzyme-linked immunosorbent assay (ELISA) tests.	Tetradecanoylphorbol Acetate	113-144	interleukin 4	Homo sapiens	23-27
15659537-0	2005	Tumor necrosis factor alpha and phorbol 12-myristate-13-acetate down-regulate human 11beta-hydroxysteroid dehydrogenase type 2 through p50/p50 NF-kappaB homodimers and Egr-1.	Tetradecanoylphorbol Acetate	32-63	nuclear factor kappa B subunit 1	Homo sapiens	135-138
15659537-0	2005	Tumor necrosis factor alpha and phorbol 12-myristate-13-acetate down-regulate human 11beta-hydroxysteroid dehydrogenase type 2 through p50/p50 NF-kappaB homodimers and Egr-1.	Tetradecanoylphorbol Acetate	32-63	nuclear factor kappa B subunit 1	Homo sapiens	139-142
15659537-0	2005	Tumor necrosis factor alpha and phorbol 12-myristate-13-acetate down-regulate human 11beta-hydroxysteroid dehydrogenase type 2 through p50/p50 NF-kappaB homodimers and Egr-1.	Tetradecanoylphorbol Acetate	32-63	nuclear factor kappa B subunit 1	Homo sapiens	143-152
15819885-1	2005	Expression of the tissue inhibitor of metalloproteinases-1 (Timp-1) gene can be induced by either phorbol myristate acetate (PMA) or transforming growth factor beta1 (TGF-beta1), although the signalling pathways involved are not clearly defined.	Tetradecanoylphorbol Acetate	98-123	tissue inhibitor of metalloproteinase 1	Mus musculus	18-58
15819885-1	2005	Expression of the tissue inhibitor of metalloproteinases-1 (Timp-1) gene can be induced by either phorbol myristate acetate (PMA) or transforming growth factor beta1 (TGF-beta1), although the signalling pathways involved are not clearly defined.	Tetradecanoylphorbol Acetate	98-123	tissue inhibitor of metalloproteinase 1	Mus musculus	60-66
15819885-1	2005	Expression of the tissue inhibitor of metalloproteinases-1 (Timp-1) gene can be induced by either phorbol myristate acetate (PMA) or transforming growth factor beta1 (TGF-beta1), although the signalling pathways involved are not clearly defined.	Tetradecanoylphorbol Acetate	125-128	tissue inhibitor of metalloproteinase 1	Mus musculus	18-58
15819885-1	2005	Expression of the tissue inhibitor of metalloproteinases-1 (Timp-1) gene can be induced by either phorbol myristate acetate (PMA) or transforming growth factor beta1 (TGF-beta1), although the signalling pathways involved are not clearly defined.	Tetradecanoylphorbol Acetate	125-128	tissue inhibitor of metalloproteinase 1	Mus musculus	60-66
15819885-4	2005	TSA or NaB potentiate PMA-induced Timp-1 expression but repress TGF-beta1-induced Timp-1 expression.	Tetradecanoylphorbol Acetate	22-25	tissue inhibitor of metalloproteinase 1	Mus musculus	34-40
15627650-4	2005	The two fatty acids inhibited the phorbol 12-myristate 13-acetate (PMA)-induced plasma membrane translocation of protein kinase C (PKC)-alpha and -epsilon.	Tetradecanoylphorbol Acetate	34-65	protein kinase C alpha	Homo sapiens	113-141
15790882-10	2005	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element.	Tetradecanoylphorbol Acetate	15-51	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	163-166
15790882-10	2005	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element.	Tetradecanoylphorbol Acetate	15-51	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	185-189
15790882-10	2005	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element.	Tetradecanoylphorbol Acetate	15-51	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	216-219
15790882-10	2005	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element.	Tetradecanoylphorbol Acetate	53-56	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	163-166
15790882-10	2005	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element.	Tetradecanoylphorbol Acetate	53-56	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	185-189
15790882-10	2005	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element.	Tetradecanoylphorbol Acetate	53-56	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	216-219
15778356-4	2005	In contrast, IL-4-cultured NK cells produced significant levels of TNF-alpha and GM-CSF only when stimulated with PMA and ionomycin.	Tetradecanoylphorbol Acetate	114-117	interleukin 4	Homo sapiens	13-17
15778356-4	2005	In contrast, IL-4-cultured NK cells produced significant levels of TNF-alpha and GM-CSF only when stimulated with PMA and ionomycin.	Tetradecanoylphorbol Acetate	114-117	tumor necrosis factor	Homo sapiens	67-76
15627650-4	2005	The two fatty acids inhibited the phorbol 12-myristate 13-acetate (PMA)-induced plasma membrane translocation of protein kinase C (PKC)-alpha and -epsilon.	Tetradecanoylphorbol Acetate	67-70	protein kinase C alpha	Homo sapiens	113-141
15579495-9	2005	The enhanced production of TNF-alpha, superoxide anion, and nitrite by isolated alveolar macrophages in response to lipopolysaccharide (3 microg/ml), PMA (10 nM), and/or zymosan (100 particles/cell) did not differ between vehicle- and capsaicin-pretreated rats.	Tetradecanoylphorbol Acetate	150-153	tumor necrosis factor	Rattus norvegicus	27-36
15632189-5	2005	Conversely, activation of PKC by 12-O-tetradecanoylphorbol-13-acetate induced DGK translocation.	Tetradecanoylphorbol Acetate	33-69	diacylglycerol kinase beta	Homo sapiens	78-81
15827341-3	2005	Pretreatment with phorbol 12-myristate 13-acetate (PMA) led to inhibition of apoptosis in the majority of the melanoma cell lines, but those with relatively low PKC epsilon expression were sensitized to TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	18-49	TNF superfamily member 10	Homo sapiens	203-208
15827341-3	2005	Pretreatment with phorbol 12-myristate 13-acetate (PMA) led to inhibition of apoptosis in the majority of the melanoma cell lines, but those with relatively low PKC epsilon expression were sensitized to TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	51-54	TNF superfamily member 10	Homo sapiens	203-208
15827341-8	2005	Activation of PKC seemed to mediate its effects upstream of mitochondria but downstream of caspase-8 and Bid in that pretreatment with PMA did not cause significant changes in the expression levels of TRAIL death receptors, alterations in the levels of caspase-8 activation, or cleavage of Bid.	Tetradecanoylphorbol Acetate	135-138	proline rich transmembrane protein 2	Homo sapiens	14-17
16011257-4	2005	The interleukin-1beta (IL-1beta) levels in mice serum and in supernatants of U937 cell culture stimulated by phorbol 12-myristate 13-acetate (PMA) were detected by radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	109-140	interleukin 1 beta	Mus musculus	4-21
16011257-4	2005	The interleukin-1beta (IL-1beta) levels in mice serum and in supernatants of U937 cell culture stimulated by phorbol 12-myristate 13-acetate (PMA) were detected by radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	109-140	interleukin 1 beta	Mus musculus	23-31
16011257-4	2005	The interleukin-1beta (IL-1beta) levels in mice serum and in supernatants of U937 cell culture stimulated by phorbol 12-myristate 13-acetate (PMA) were detected by radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	142-145	interleukin 1 beta	Mus musculus	4-21
16011257-4	2005	The interleukin-1beta (IL-1beta) levels in mice serum and in supernatants of U937 cell culture stimulated by phorbol 12-myristate 13-acetate (PMA) were detected by radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	142-145	interleukin 1 beta	Mus musculus	23-31
15828232-5	2005	In addition, the phorbol myristate acetate (PMA)-stimulated 22 kDa-subunit (p22phox) protein levels and 47 kDa-subunit (p47phox) protein levels in NADPH (superoxide generating enzyme nicotinamide adenine dinucleotide phosphate (reduced form)) oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	17-42	peroxisome proliferator activated receptor gamma	Homo sapiens	298-307
15828232-5	2005	In addition, the phorbol myristate acetate (PMA)-stimulated 22 kDa-subunit (p22phox) protein levels and 47 kDa-subunit (p47phox) protein levels in NADPH (superoxide generating enzyme nicotinamide adenine dinucleotide phosphate (reduced form)) oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	44-47	peroxisome proliferator activated receptor gamma	Homo sapiens	298-307
15748703-6	2005	A PKC activator, 12-O-tetradecaoylphorbol-13-acetate (TPA) significantly attenuated ME-induced apoptosis via preventing cytochrome c release to the cytosol and maintaining the mitochondrial membrane potential by inhibiting the decrease in the Bcl-2/Bax protein ratio; these effects were blocked by protein kinase C (PKC) inhibitors including GF-109203X, H7, and staurosporin.	Tetradecanoylphorbol Acetate	54-57	cytochrome c, somatic	Homo sapiens	120-132
15748703-6	2005	A PKC activator, 12-O-tetradecaoylphorbol-13-acetate (TPA) significantly attenuated ME-induced apoptosis via preventing cytochrome c release to the cytosol and maintaining the mitochondrial membrane potential by inhibiting the decrease in the Bcl-2/Bax protein ratio; these effects were blocked by protein kinase C (PKC) inhibitors including GF-109203X, H7, and staurosporin.	Tetradecanoylphorbol Acetate	54-57	BCL2 apoptosis regulator	Homo sapiens	243-248
15748703-6	2005	A PKC activator, 12-O-tetradecaoylphorbol-13-acetate (TPA) significantly attenuated ME-induced apoptosis via preventing cytochrome c release to the cytosol and maintaining the mitochondrial membrane potential by inhibiting the decrease in the Bcl-2/Bax protein ratio; these effects were blocked by protein kinase C (PKC) inhibitors including GF-109203X, H7, and staurosporin.	Tetradecanoylphorbol Acetate	54-57	BCL2 associated X, apoptosis regulator	Homo sapiens	249-252
15632134-3	2005	Intracellular phosphorylation analysis showed that phosphorylated PKCalpha and other kinases were lower in wild-type mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) as compared with PPARbeta-null mouse skin.	Tetradecanoylphorbol Acetate	141-177	protein kinase C, alpha	Mus musculus	66-74
15632134-3	2005	Intracellular phosphorylation analysis showed that phosphorylated PKCalpha and other kinases were lower in wild-type mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) as compared with PPARbeta-null mouse skin.	Tetradecanoylphorbol Acetate	141-177	peroxisome proliferator activator receptor delta	Mus musculus	201-209
15632134-6	2005	The activity of PKCalpha and downstream signaling kinases is enhanced, and expression of cyclooxygenase-2 (COX-2) is significantly greater, in PPARbeta-null mouse skin in response to TPA compared with wild-type mouse skin.	Tetradecanoylphorbol Acetate	183-186	protein kinase C, alpha	Mus musculus	16-24
15632134-3	2005	Intracellular phosphorylation analysis showed that phosphorylated PKCalpha and other kinases were lower in wild-type mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) as compared with PPARbeta-null mouse skin.	Tetradecanoylphorbol Acetate	179-182	protein kinase C, alpha	Mus musculus	66-74
15632134-6	2005	The activity of PKCalpha and downstream signaling kinases is enhanced, and expression of cyclooxygenase-2 (COX-2) is significantly greater, in PPARbeta-null mouse skin in response to TPA compared with wild-type mouse skin.	Tetradecanoylphorbol Acetate	183-186	peroxisome proliferator activator receptor delta	Mus musculus	143-151
15632134-3	2005	Intracellular phosphorylation analysis showed that phosphorylated PKCalpha and other kinases were lower in wild-type mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) as compared with PPARbeta-null mouse skin.	Tetradecanoylphorbol Acetate	179-182	peroxisome proliferator activator receptor delta	Mus musculus	201-209
15632134-7	2005	Inhibition of PKCalpha or COX-2 reduced cell proliferation in TPA-treated PPARbeta-null keratinocytes in a dose-dependent manner, whereas it only slightly influenced cell proliferation in wild-type keratinocytes.	Tetradecanoylphorbol Acetate	62-65	protein kinase C, alpha	Mus musculus	14-22
15632134-5	2005	Lower ubiquitination of PKCalpha was found in TPA-treated PPARbeta-null skin as compared with wild-type, and inhibition of ubiquitin-dependent proteasome degradation prevented TPA-induced down-regulation of PKCalpha.	Tetradecanoylphorbol Acetate	46-49	protein kinase C, alpha	Mus musculus	24-32
15632134-7	2005	Inhibition of PKCalpha or COX-2 reduced cell proliferation in TPA-treated PPARbeta-null keratinocytes in a dose-dependent manner, whereas it only slightly influenced cell proliferation in wild-type keratinocytes.	Tetradecanoylphorbol Acetate	62-65	peroxisome proliferator activator receptor delta	Mus musculus	74-82
15632134-5	2005	Lower ubiquitination of PKCalpha was found in TPA-treated PPARbeta-null skin as compared with wild-type, and inhibition of ubiquitin-dependent proteasome degradation prevented TPA-induced down-regulation of PKCalpha.	Tetradecanoylphorbol Acetate	46-49	peroxisome proliferator activator receptor delta	Mus musculus	58-66
15632146-7	2005	Furthermore, mutation or deletion of NFAT binding sites in the human COX-2 promoter greatly diminished its induction by phorbol 12-myristate 13-acetate/calcium ionophore A23187.	Tetradecanoylphorbol Acetate	120-151	prostaglandin-endoperoxide synthase 2	Homo sapiens	69-74
15632134-5	2005	Lower ubiquitination of PKCalpha was found in TPA-treated PPARbeta-null skin as compared with wild-type, and inhibition of ubiquitin-dependent proteasome degradation prevented TPA-induced down-regulation of PKCalpha.	Tetradecanoylphorbol Acetate	46-49	protein kinase C, alpha	Mus musculus	207-215
15632134-5	2005	Lower ubiquitination of PKCalpha was found in TPA-treated PPARbeta-null skin as compared with wild-type, and inhibition of ubiquitin-dependent proteasome degradation prevented TPA-induced down-regulation of PKCalpha.	Tetradecanoylphorbol Acetate	176-179	protein kinase C, alpha	Mus musculus	24-32
15632134-5	2005	Lower ubiquitination of PKCalpha was found in TPA-treated PPARbeta-null skin as compared with wild-type, and inhibition of ubiquitin-dependent proteasome degradation prevented TPA-induced down-regulation of PKCalpha.	Tetradecanoylphorbol Acetate	176-179	peroxisome proliferator activator receptor delta	Mus musculus	58-66
15632134-5	2005	Lower ubiquitination of PKCalpha was found in TPA-treated PPARbeta-null skin as compared with wild-type, and inhibition of ubiquitin-dependent proteasome degradation prevented TPA-induced down-regulation of PKCalpha.	Tetradecanoylphorbol Acetate	176-179	protein kinase C, alpha	Mus musculus	207-215
15618223-0	2005	Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells.	Tetradecanoylphorbol Acetate	0-31	epidermal growth factor receptor	Homo sapiens	40-72
15707584-4	2005	We report that three distinct MAPKs, ERK, JNK, and p38, are activated during the TPA-induced megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	81-84	mitogen-activated protein kinase 1	Homo sapiens	37-40
15707584-4	2005	We report that three distinct MAPKs, ERK, JNK, and p38, are activated during the TPA-induced megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	81-84	mitogen-activated protein kinase 8	Homo sapiens	42-45
15707584-4	2005	We report that three distinct MAPKs, ERK, JNK, and p38, are activated during the TPA-induced megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	81-84	mitogen-activated protein kinase 14	Homo sapiens	51-54
15707588-4	2005	PKC activation by 12-myristate 13-acetate (PMA) and ingenol 3,20-dibenzoate (IDB) also led to an increased PPRE activation, and this action was additive to PPAR gamma activators and 9-cis RA, but not to proteasome inhibitors.	Tetradecanoylphorbol Acetate	43-46	peroxisome proliferator activated receptor gamma	Homo sapiens	156-166
15618223-5	2005	PMA-induced phosphorylation of the EGFR at Tyr(1068) was blocked by bisindolylmaleimide (BIM), a PKC inhibitor, and rottlerin, a PKCdelta-specific inhibitor.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor receptor	Homo sapiens	35-39
15760676-5	2005	Using PMA (a potent pharmacological activator of PKC) and calphostin C (a specific PKC inhibitor), we demonstrated an up-regulation of IL-8 in NCTC 2544 cells and a down-regulation of the cytokine in UVB-irradiated cells, respectively.	Tetradecanoylphorbol Acetate	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	135-139
15760676-6	2005	We also observed that in our experimental conditions, staurosporine, an inhibitor of both PKC and PMA-stimulated cellular responses, does not involve PKC inhibition in irradiated cells and significantly decreased NF-kappa B activity in response to UVB radiation.	Tetradecanoylphorbol Acetate	98-101	nuclear factor kappa B subunit 1	Homo sapiens	213-223
15618223-8	2005	PMA induced serine/threonine phosphorylation of Src, which was blocked by both BIM and rottlerin.	Tetradecanoylphorbol Acetate	0-3	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	48-51
15618223-0	2005	Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells.	Tetradecanoylphorbol Acetate	0-31	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	115-120
15618223-3	2005	Interestingly, phorbol 12-myristate 13-acetate (PMA) stimulated phosphorylation of the EGFR only at Tyr(1068) in the two glioblastoma cell lines.	Tetradecanoylphorbol Acetate	15-46	epidermal growth factor receptor	Homo sapiens	87-91
15623535-2	2005	Recently, we have shown that PKC isoforms-alpha and -delta, as well as the Rho/Rho kinase (ROK) pathway, play a role in phorbol 12-myristate 13-acetate (PMA)-mediated secretion of the gut peptide neurotensin (NT) in the BON human endocrine cell line.	Tetradecanoylphorbol Acetate	120-151	protein kinase C alpha	Homo sapiens	29-58
15623535-2	2005	Recently, we have shown that PKC isoforms-alpha and -delta, as well as the Rho/Rho kinase (ROK) pathway, play a role in phorbol 12-myristate 13-acetate (PMA)-mediated secretion of the gut peptide neurotensin (NT) in the BON human endocrine cell line.	Tetradecanoylphorbol Acetate	120-151	neurotensin	Homo sapiens	196-207
15623535-2	2005	Recently, we have shown that PKC isoforms-alpha and -delta, as well as the Rho/Rho kinase (ROK) pathway, play a role in phorbol 12-myristate 13-acetate (PMA)-mediated secretion of the gut peptide neurotensin (NT) in the BON human endocrine cell line.	Tetradecanoylphorbol Acetate	153-156	protein kinase C alpha	Homo sapiens	29-58
15670752-0	2005	Tetradecanoyl phorbol acetate induces expression of Toll-like receptor 2 in U937 cells: involvement of PKC, ERK, and NF-kappaB.	Tetradecanoylphorbol Acetate	0-29	toll like receptor 2	Homo sapiens	52-72
15618223-3	2005	Interestingly, phorbol 12-myristate 13-acetate (PMA) stimulated phosphorylation of the EGFR only at Tyr(1068) in the two glioblastoma cell lines.	Tetradecanoylphorbol Acetate	48-51	epidermal growth factor receptor	Homo sapiens	87-91
15623535-2	2005	Recently, we have shown that PKC isoforms-alpha and -delta, as well as the Rho/Rho kinase (ROK) pathway, play a role in phorbol 12-myristate 13-acetate (PMA)-mediated secretion of the gut peptide neurotensin (NT) in the BON human endocrine cell line.	Tetradecanoylphorbol Acetate	153-156	neurotensin	Homo sapiens	196-207
15670752-7	2005	Pretreatments with GF109203X blocked TPA-induced phosphorylation of ERKs, suggesting activation of ERKs by PKC.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 1	Homo sapiens	68-72
15670752-0	2005	Tetradecanoyl phorbol acetate induces expression of Toll-like receptor 2 in U937 cells: involvement of PKC, ERK, and NF-kappaB.	Tetradecanoylphorbol Acetate	0-29	proline rich transmembrane protein 2	Homo sapiens	103-106
15670752-0	2005	Tetradecanoyl phorbol acetate induces expression of Toll-like receptor 2 in U937 cells: involvement of PKC, ERK, and NF-kappaB.	Tetradecanoylphorbol Acetate	0-29	mitogen-activated protein kinase 1	Homo sapiens	108-111
15670752-0	2005	Tetradecanoyl phorbol acetate induces expression of Toll-like receptor 2 in U937 cells: involvement of PKC, ERK, and NF-kappaB.	Tetradecanoylphorbol Acetate	0-29	nuclear factor kappa B subunit 1	Homo sapiens	117-126
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	36-73	toll like receptor 2	Homo sapiens	20-24
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	75-78	toll like receptor 2	Homo sapiens	20-24
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	149-152	toll like receptor 2	Homo sapiens	20-24
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	149-152	toll like receptor 2	Homo sapiens	166-170
15670752-3	2005	In this study, we investigated the effect of TPA on induction of TLR2 in U937 cells.	Tetradecanoylphorbol Acetate	45-48	toll like receptor 2	Homo sapiens	65-69
15670752-4	2005	TPA markedly induced TLR2 mRNA and protein expressions.	Tetradecanoylphorbol Acetate	0-3	toll like receptor 2	Homo sapiens	21-25
15670752-5	2005	TLR2 expression in response to TPA was attenuated by pretreatments with GF109203X and Go6976 (inhibitors of protein kinase C (PKC)) and PD98059 (an inhibitor of extracellular signal-regulated kinases (ERKs)), but not SB203580 (an inhibitor of p38s) and SP600125 (an inhibitor of c-Jun N-terminal kinases), suggesting involvement of PKC and ERKs in this response.	Tetradecanoylphorbol Acetate	31-34	toll like receptor 2	Homo sapiens	0-4
15670752-5	2005	TLR2 expression in response to TPA was attenuated by pretreatments with GF109203X and Go6976 (inhibitors of protein kinase C (PKC)) and PD98059 (an inhibitor of extracellular signal-regulated kinases (ERKs)), but not SB203580 (an inhibitor of p38s) and SP600125 (an inhibitor of c-Jun N-terminal kinases), suggesting involvement of PKC and ERKs in this response.	Tetradecanoylphorbol Acetate	31-34	proline rich transmembrane protein 2	Homo sapiens	108-124
15670752-7	2005	Pretreatments with GF109203X blocked TPA-induced phosphorylation of ERKs, suggesting activation of ERKs by PKC.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 1	Homo sapiens	99-103
15670752-5	2005	TLR2 expression in response to TPA was attenuated by pretreatments with GF109203X and Go6976 (inhibitors of protein kinase C (PKC)) and PD98059 (an inhibitor of extracellular signal-regulated kinases (ERKs)), but not SB203580 (an inhibitor of p38s) and SP600125 (an inhibitor of c-Jun N-terminal kinases), suggesting involvement of PKC and ERKs in this response.	Tetradecanoylphorbol Acetate	31-34	proline rich transmembrane protein 2	Homo sapiens	126-129
15670752-5	2005	TLR2 expression in response to TPA was attenuated by pretreatments with GF109203X and Go6976 (inhibitors of protein kinase C (PKC)) and PD98059 (an inhibitor of extracellular signal-regulated kinases (ERKs)), but not SB203580 (an inhibitor of p38s) and SP600125 (an inhibitor of c-Jun N-terminal kinases), suggesting involvement of PKC and ERKs in this response.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 1	Homo sapiens	201-205
15670752-7	2005	Pretreatments with GF109203X blocked TPA-induced phosphorylation of ERKs, suggesting activation of ERKs by PKC.	Tetradecanoylphorbol Acetate	37-40	proline rich transmembrane protein 2	Homo sapiens	107-110
15670752-5	2005	TLR2 expression in response to TPA was attenuated by pretreatments with GF109203X and Go6976 (inhibitors of protein kinase C (PKC)) and PD98059 (an inhibitor of extracellular signal-regulated kinases (ERKs)), but not SB203580 (an inhibitor of p38s) and SP600125 (an inhibitor of c-Jun N-terminal kinases), suggesting involvement of PKC and ERKs in this response.	Tetradecanoylphorbol Acetate	31-34	proline rich transmembrane protein 2	Homo sapiens	332-335
15670752-8	2005	In addition, TPA induced nuclear factor-kappaB (NF-kappaB) activation, which was shown by increased nuclear translocation of p65 NF-kappaB and degradation of IkappaB-alpha, a NF-kappaB inhibitory protein.	Tetradecanoylphorbol Acetate	13-16	nuclear factor kappa B subunit 1	Homo sapiens	48-57
15670752-5	2005	TLR2 expression in response to TPA was attenuated by pretreatments with GF109203X and Go6976 (inhibitors of protein kinase C (PKC)) and PD98059 (an inhibitor of extracellular signal-regulated kinases (ERKs)), but not SB203580 (an inhibitor of p38s) and SP600125 (an inhibitor of c-Jun N-terminal kinases), suggesting involvement of PKC and ERKs in this response.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 1	Homo sapiens	340-344
15670752-8	2005	In addition, TPA induced nuclear factor-kappaB (NF-kappaB) activation, which was shown by increased nuclear translocation of p65 NF-kappaB and degradation of IkappaB-alpha, a NF-kappaB inhibitory protein.	Tetradecanoylphorbol Acetate	13-16	nuclear factor kappa B subunit 1	Homo sapiens	129-138
15670752-6	2005	Moreover, TPA-induced PKC activation was linked to generation of reactive oxygen species, which were dispensable for TLR2 expression in U937 cells.	Tetradecanoylphorbol Acetate	10-13	proline rich transmembrane protein 2	Homo sapiens	22-25
15670752-8	2005	In addition, TPA induced nuclear factor-kappaB (NF-kappaB) activation, which was shown by increased nuclear translocation of p65 NF-kappaB and degradation of IkappaB-alpha, a NF-kappaB inhibitory protein.	Tetradecanoylphorbol Acetate	13-16	NFKB inhibitor alpha	Homo sapiens	158-171
15670752-8	2005	In addition, TPA induced nuclear factor-kappaB (NF-kappaB) activation, which was shown by increased nuclear translocation of p65 NF-kappaB and degradation of IkappaB-alpha, a NF-kappaB inhibitory protein.	Tetradecanoylphorbol Acetate	13-16	nuclear factor kappa B subunit 1	Homo sapiens	129-138
15670752-9	2005	Importantly, TPA-induced TLR2 expression was inhibited by blockage of NF-kappaB activation using NF-kappaB inhibitors, including MG132 and BAY11-7085.	Tetradecanoylphorbol Acetate	13-16	toll like receptor 2	Homo sapiens	25-29
15670752-9	2005	Importantly, TPA-induced TLR2 expression was inhibited by blockage of NF-kappaB activation using NF-kappaB inhibitors, including MG132 and BAY11-7085.	Tetradecanoylphorbol Acetate	13-16	nuclear factor kappa B subunit 1	Homo sapiens	70-79
15670752-9	2005	Importantly, TPA-induced TLR2 expression was inhibited by blockage of NF-kappaB activation using NF-kappaB inhibitors, including MG132 and BAY11-7085.	Tetradecanoylphorbol Acetate	13-16	nuclear factor kappa B subunit 1	Homo sapiens	97-106
15670752-10	2005	Specifically, TPA-induced nuclear translocation of NF-kappaB was effectively attenuated by GF109203X and PD98059, suggesting PKC and ERK regulation of NF-kappaB nuclear localization in response to TPA.	Tetradecanoylphorbol Acetate	14-17	nuclear factor kappa B subunit 1	Homo sapiens	51-60
15670752-10	2005	Specifically, TPA-induced nuclear translocation of NF-kappaB was effectively attenuated by GF109203X and PD98059, suggesting PKC and ERK regulation of NF-kappaB nuclear localization in response to TPA.	Tetradecanoylphorbol Acetate	14-17	proline rich transmembrane protein 2	Homo sapiens	125-128
15670752-10	2005	Specifically, TPA-induced nuclear translocation of NF-kappaB was effectively attenuated by GF109203X and PD98059, suggesting PKC and ERK regulation of NF-kappaB nuclear localization in response to TPA.	Tetradecanoylphorbol Acetate	14-17	mitogen-activated protein kinase 1	Homo sapiens	133-136
15670752-10	2005	Specifically, TPA-induced nuclear translocation of NF-kappaB was effectively attenuated by GF109203X and PD98059, suggesting PKC and ERK regulation of NF-kappaB nuclear localization in response to TPA.	Tetradecanoylphorbol Acetate	14-17	nuclear factor kappa B subunit 1	Homo sapiens	151-160
15670752-10	2005	Specifically, TPA-induced nuclear translocation of NF-kappaB was effectively attenuated by GF109203X and PD98059, suggesting PKC and ERK regulation of NF-kappaB nuclear localization in response to TPA.	Tetradecanoylphorbol Acetate	197-200	nuclear factor kappa B subunit 1	Homo sapiens	51-60
15670752-10	2005	Specifically, TPA-induced nuclear translocation of NF-kappaB was effectively attenuated by GF109203X and PD98059, suggesting PKC and ERK regulation of NF-kappaB nuclear localization in response to TPA.	Tetradecanoylphorbol Acetate	197-200	proline rich transmembrane protein 2	Homo sapiens	125-128
15670752-10	2005	Specifically, TPA-induced nuclear translocation of NF-kappaB was effectively attenuated by GF109203X and PD98059, suggesting PKC and ERK regulation of NF-kappaB nuclear localization in response to TPA.	Tetradecanoylphorbol Acetate	197-200	mitogen-activated protein kinase 1	Homo sapiens	133-136
15670752-10	2005	Specifically, TPA-induced nuclear translocation of NF-kappaB was effectively attenuated by GF109203X and PD98059, suggesting PKC and ERK regulation of NF-kappaB nuclear localization in response to TPA.	Tetradecanoylphorbol Acetate	197-200	nuclear factor kappa B subunit 1	Homo sapiens	151-160
15670752-11	2005	Together, these results suggest that TPA-induced TLR2 expression in U937 cells may be at least in part mediated through activation of PKC and ERKs as well as NF-kappaB transcription factor, and that cross-talk between PKC or ERKs and NF-kappaB may exist.	Tetradecanoylphorbol Acetate	37-40	toll like receptor 2	Homo sapiens	49-53
15670752-11	2005	Together, these results suggest that TPA-induced TLR2 expression in U937 cells may be at least in part mediated through activation of PKC and ERKs as well as NF-kappaB transcription factor, and that cross-talk between PKC or ERKs and NF-kappaB may exist.	Tetradecanoylphorbol Acetate	37-40	proline rich transmembrane protein 2	Homo sapiens	134-137
15710363-7	2005	In mammalian two-hybrid assays, treatment with phorbol 12-myristate 13-acetate (PMA) increased the strength of interaction between PXR and the nuclear receptor co-repressor protein (NCoR).	Tetradecanoylphorbol Acetate	47-78	nuclear receptor subfamily 1 group I member 2	Homo sapiens	131-134
15670752-11	2005	Together, these results suggest that TPA-induced TLR2 expression in U937 cells may be at least in part mediated through activation of PKC and ERKs as well as NF-kappaB transcription factor, and that cross-talk between PKC or ERKs and NF-kappaB may exist.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 1	Homo sapiens	142-146
15710363-7	2005	In mammalian two-hybrid assays, treatment with phorbol 12-myristate 13-acetate (PMA) increased the strength of interaction between PXR and the nuclear receptor co-repressor protein (NCoR).	Tetradecanoylphorbol Acetate	80-83	nuclear receptor subfamily 1 group I member 2	Homo sapiens	131-134
15670752-11	2005	Together, these results suggest that TPA-induced TLR2 expression in U937 cells may be at least in part mediated through activation of PKC and ERKs as well as NF-kappaB transcription factor, and that cross-talk between PKC or ERKs and NF-kappaB may exist.	Tetradecanoylphorbol Acetate	37-40	nuclear factor kappa B subunit 1	Homo sapiens	158-167
15710363-8	2005	Treatment with PMA also abolished the ligand-dependent interaction between PXR and the steroid receptor co-activator 1 protein (SRC1).	Tetradecanoylphorbol Acetate	15-18	nuclear receptor subfamily 1 group I member 2	Homo sapiens	75-78
15670752-11	2005	Together, these results suggest that TPA-induced TLR2 expression in U937 cells may be at least in part mediated through activation of PKC and ERKs as well as NF-kappaB transcription factor, and that cross-talk between PKC or ERKs and NF-kappaB may exist.	Tetradecanoylphorbol Acetate	37-40	proline rich transmembrane protein 2	Homo sapiens	218-221
15670752-11	2005	Together, these results suggest that TPA-induced TLR2 expression in U937 cells may be at least in part mediated through activation of PKC and ERKs as well as NF-kappaB transcription factor, and that cross-talk between PKC or ERKs and NF-kappaB may exist.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 1	Homo sapiens	225-229
15670752-11	2005	Together, these results suggest that TPA-induced TLR2 expression in U937 cells may be at least in part mediated through activation of PKC and ERKs as well as NF-kappaB transcription factor, and that cross-talk between PKC or ERKs and NF-kappaB may exist.	Tetradecanoylphorbol Acetate	37-40	nuclear factor kappa B subunit 1	Homo sapiens	234-243
15567061-5	2005	PMA-mediated activation of ERK1/2 was inhibited by Ro 31-8220, manumycin A, GW 5074, and PD 098059.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	27-33
15721870-6	2005	Protein kinase C (PKC) has been reported to phosphorylate this residue, and the increase in the phosphorylation of Thr(495) induced by phorbol 12-myristate 13-acetate was attenuated in cells pretreated with ox-LDL.	Tetradecanoylphorbol Acetate	135-166	protein kinase C alpha	Homo sapiens	18-21
15567061-0	2005	Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways.	Tetradecanoylphorbol Acetate	0-31	prostaglandin-endoperoxide synthase 2	Homo sapiens	44-60
15567061-0	2005	Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 1	Homo sapiens	124-127
15538571-12	2005	Moreover, PMA showed reinforcement, while doxorubicin showed significant antagonization, of the quercetin-mediated decrease in the expression of Bcl-2.	Tetradecanoylphorbol Acetate	10-13	B cell leukemia/lymphoma 2	Mus musculus	145-150
15567061-8	2005	Taken together, these results indicate that PMA might activate PKC to elicit activation of the Ras/Raf-1/ERK1/2 pathway, which in turn initiates NF-kappaB activation, and finally induces COX-2 expression and PGE2 release in A549 cells.	Tetradecanoylphorbol Acetate	44-47	mitogen-activated protein kinase 3	Homo sapiens	105-111
15567061-1	2005	In this study, we investigated the signaling pathway involved in cyclooxygenase-2 (COX-2) expression and prostaglandin E2 (PGE2) release by phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, in human pulmonary epithelial cells (A549).	Tetradecanoylphorbol Acetate	140-171	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-88
15567061-1	2005	In this study, we investigated the signaling pathway involved in cyclooxygenase-2 (COX-2) expression and prostaglandin E2 (PGE2) release by phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, in human pulmonary epithelial cells (A549).	Tetradecanoylphorbol Acetate	173-176	prostaglandin-endoperoxide synthase 2	Homo sapiens	65-81
15567061-1	2005	In this study, we investigated the signaling pathway involved in cyclooxygenase-2 (COX-2) expression and prostaglandin E2 (PGE2) release by phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, in human pulmonary epithelial cells (A549).	Tetradecanoylphorbol Acetate	173-176	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-88
15567061-2	2005	PMA-induced COX-2 expression was attenuated by PKC inhibitors (Go 6976 and Ro 31-8220), a Ras inhibitor (manumycin A), a Raf-1 inhibitor (GW 5074), a MEK inhibitor (PD 098059), and an NF-kappaB inhibitor (PDTC), but not by a tyrosine kinase inhibitor (genistein) or a p38 MAPK inhibitor (SB 203580).	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Homo sapiens	12-17
15567061-2	2005	PMA-induced COX-2 expression was attenuated by PKC inhibitors (Go 6976 and Ro 31-8220), a Ras inhibitor (manumycin A), a Raf-1 inhibitor (GW 5074), a MEK inhibitor (PD 098059), and an NF-kappaB inhibitor (PDTC), but not by a tyrosine kinase inhibitor (genistein) or a p38 MAPK inhibitor (SB 203580).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 7	Homo sapiens	150-153
15567061-2	2005	PMA-induced COX-2 expression was attenuated by PKC inhibitors (Go 6976 and Ro 31-8220), a Ras inhibitor (manumycin A), a Raf-1 inhibitor (GW 5074), a MEK inhibitor (PD 098059), and an NF-kappaB inhibitor (PDTC), but not by a tyrosine kinase inhibitor (genistein) or a p38 MAPK inhibitor (SB 203580).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	268-271
15567061-8	2005	Taken together, these results indicate that PMA might activate PKC to elicit activation of the Ras/Raf-1/ERK1/2 pathway, which in turn initiates NF-kappaB activation, and finally induces COX-2 expression and PGE2 release in A549 cells.	Tetradecanoylphorbol Acetate	44-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	187-192
21432144-7	2005	Furthermore, we found that 12-O-tetradecanoylphorbol-13-acetate (TPA), which is widely used as a tumor promoter and protein kinase C activator, promotes human cancer cell growth through the down-regulation of p18(INK4c) gene expression.	Tetradecanoylphorbol Acetate	27-63	cyclin dependent kinase inhibitor 2C	Homo sapiens	209-212
15698597-16	2005	L-cystathionine and N-acetyl-L-cysteine suppressed fMLP- and PMA-induced superoxide generation by the inhibition of translocation to membrane of p47(phox) and p67(phox).	Tetradecanoylphorbol Acetate	61-64	CD33 molecule	Homo sapiens	159-162
21432144-7	2005	Furthermore, we found that 12-O-tetradecanoylphorbol-13-acetate (TPA), which is widely used as a tumor promoter and protein kinase C activator, promotes human cancer cell growth through the down-regulation of p18(INK4c) gene expression.	Tetradecanoylphorbol Acetate	27-63	cyclin dependent kinase inhibitor 2C	Homo sapiens	213-218
21432144-7	2005	Furthermore, we found that 12-O-tetradecanoylphorbol-13-acetate (TPA), which is widely used as a tumor promoter and protein kinase C activator, promotes human cancer cell growth through the down-regulation of p18(INK4c) gene expression.	Tetradecanoylphorbol Acetate	65-68	cyclin dependent kinase inhibitor 2C	Homo sapiens	209-212
21432144-7	2005	Furthermore, we found that 12-O-tetradecanoylphorbol-13-acetate (TPA), which is widely used as a tumor promoter and protein kinase C activator, promotes human cancer cell growth through the down-regulation of p18(INK4c) gene expression.	Tetradecanoylphorbol Acetate	65-68	cyclin dependent kinase inhibitor 2C	Homo sapiens	213-218
15703835-1	2005	The ability of peptide hormones, as well as the protein kinase C (PKC)-activating phorbol ester (PMA), to protect cells from apoptosis has been demonstrated to occur through activation of cellular signaling pathways such as the mitogen-activated protein kinase (MAPK) and phosphatidyl-inositol-3 kinase (PI3K) families.	Tetradecanoylphorbol Acetate	97-100	proline rich transmembrane protein 2	Homo sapiens	48-64
15703835-1	2005	The ability of peptide hormones, as well as the protein kinase C (PKC)-activating phorbol ester (PMA), to protect cells from apoptosis has been demonstrated to occur through activation of cellular signaling pathways such as the mitogen-activated protein kinase (MAPK) and phosphatidyl-inositol-3 kinase (PI3K) families.	Tetradecanoylphorbol Acetate	97-100	proline rich transmembrane protein 2	Homo sapiens	66-69
15385432-1	2005	Previous studies have demonstrated that the activity of GM3 synthase and GM3 content are increased during the differentiation of human promyelocytic leukemia HL-60 cells into the monocyte/macrophage lineage after phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	213-244	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	56-68
15385432-1	2005	Previous studies have demonstrated that the activity of GM3 synthase and GM3 content are increased during the differentiation of human promyelocytic leukemia HL-60 cells into the monocyte/macrophage lineage after phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	246-249	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	56-68
15703835-1	2005	The ability of peptide hormones, as well as the protein kinase C (PKC)-activating phorbol ester (PMA), to protect cells from apoptosis has been demonstrated to occur through activation of cellular signaling pathways such as the mitogen-activated protein kinase (MAPK) and phosphatidyl-inositol-3 kinase (PI3K) families.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 1	Homo sapiens	262-266
15537826-8	2005	Indeed, we found that inhibition of ERK-1/2 phosphorylation (activation) inhibited TPA-induced transglutaminase activity.	Tetradecanoylphorbol Acetate	83-86	mitogen-activated protein kinase 1	Mus musculus	36-43
15389569-7	2005	When primary cultured hepatocytes were treated with tetradecanoylphorbol acetate (TPA) to induce T654-phosphorylation of EGFR, we found colocalization of a fraction of EGFR with EEA1, downregulation of EGF-mediated EGFR autophosphorylation, altered ligand-induced intracellular sorting of EGFR, and increased mitogenic signaling through the EGFR-Ras-Raf-ERK pathway.	Tetradecanoylphorbol Acetate	52-80	epidermal growth factor receptor	Homo sapiens	121-125
15389569-7	2005	When primary cultured hepatocytes were treated with tetradecanoylphorbol acetate (TPA) to induce T654-phosphorylation of EGFR, we found colocalization of a fraction of EGFR with EEA1, downregulation of EGF-mediated EGFR autophosphorylation, altered ligand-induced intracellular sorting of EGFR, and increased mitogenic signaling through the EGFR-Ras-Raf-ERK pathway.	Tetradecanoylphorbol Acetate	52-80	epidermal growth factor receptor	Homo sapiens	168-172
15389569-7	2005	When primary cultured hepatocytes were treated with tetradecanoylphorbol acetate (TPA) to induce T654-phosphorylation of EGFR, we found colocalization of a fraction of EGFR with EEA1, downregulation of EGF-mediated EGFR autophosphorylation, altered ligand-induced intracellular sorting of EGFR, and increased mitogenic signaling through the EGFR-Ras-Raf-ERK pathway.	Tetradecanoylphorbol Acetate	52-80	epidermal growth factor receptor	Homo sapiens	168-172
15389569-7	2005	When primary cultured hepatocytes were treated with tetradecanoylphorbol acetate (TPA) to induce T654-phosphorylation of EGFR, we found colocalization of a fraction of EGFR with EEA1, downregulation of EGF-mediated EGFR autophosphorylation, altered ligand-induced intracellular sorting of EGFR, and increased mitogenic signaling through the EGFR-Ras-Raf-ERK pathway.	Tetradecanoylphorbol Acetate	52-80	epidermal growth factor receptor	Homo sapiens	168-172
15389569-7	2005	When primary cultured hepatocytes were treated with tetradecanoylphorbol acetate (TPA) to induce T654-phosphorylation of EGFR, we found colocalization of a fraction of EGFR with EEA1, downregulation of EGF-mediated EGFR autophosphorylation, altered ligand-induced intracellular sorting of EGFR, and increased mitogenic signaling through the EGFR-Ras-Raf-ERK pathway.	Tetradecanoylphorbol Acetate	52-80	epidermal growth factor receptor	Homo sapiens	168-172
15389569-7	2005	When primary cultured hepatocytes were treated with tetradecanoylphorbol acetate (TPA) to induce T654-phosphorylation of EGFR, we found colocalization of a fraction of EGFR with EEA1, downregulation of EGF-mediated EGFR autophosphorylation, altered ligand-induced intracellular sorting of EGFR, and increased mitogenic signaling through the EGFR-Ras-Raf-ERK pathway.	Tetradecanoylphorbol Acetate	82-85	epidermal growth factor receptor	Homo sapiens	121-125
15389569-7	2005	When primary cultured hepatocytes were treated with tetradecanoylphorbol acetate (TPA) to induce T654-phosphorylation of EGFR, we found colocalization of a fraction of EGFR with EEA1, downregulation of EGF-mediated EGFR autophosphorylation, altered ligand-induced intracellular sorting of EGFR, and increased mitogenic signaling through the EGFR-Ras-Raf-ERK pathway.	Tetradecanoylphorbol Acetate	82-85	epidermal growth factor receptor	Homo sapiens	168-172
15389569-7	2005	When primary cultured hepatocytes were treated with tetradecanoylphorbol acetate (TPA) to induce T654-phosphorylation of EGFR, we found colocalization of a fraction of EGFR with EEA1, downregulation of EGF-mediated EGFR autophosphorylation, altered ligand-induced intracellular sorting of EGFR, and increased mitogenic signaling through the EGFR-Ras-Raf-ERK pathway.	Tetradecanoylphorbol Acetate	82-85	epidermal growth factor receptor	Homo sapiens	168-172
15389569-7	2005	When primary cultured hepatocytes were treated with tetradecanoylphorbol acetate (TPA) to induce T654-phosphorylation of EGFR, we found colocalization of a fraction of EGFR with EEA1, downregulation of EGF-mediated EGFR autophosphorylation, altered ligand-induced intracellular sorting of EGFR, and increased mitogenic signaling through the EGFR-Ras-Raf-ERK pathway.	Tetradecanoylphorbol Acetate	82-85	epidermal growth factor receptor	Homo sapiens	168-172
15389569-7	2005	When primary cultured hepatocytes were treated with tetradecanoylphorbol acetate (TPA) to induce T654-phosphorylation of EGFR, we found colocalization of a fraction of EGFR with EEA1, downregulation of EGF-mediated EGFR autophosphorylation, altered ligand-induced intracellular sorting of EGFR, and increased mitogenic signaling through the EGFR-Ras-Raf-ERK pathway.	Tetradecanoylphorbol Acetate	82-85	epidermal growth factor receptor	Homo sapiens	168-172
15494549-7	2005	TPA did not lower but instead induced catalytically active CYP2E1 in these cells.	Tetradecanoylphorbol Acetate	0-3	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	59-65
15494549-8	2005	The protective effect of TPA on CYP2E1-dependent AA + Fe toxicity seemed to involve a PKC-related survival mechanism, since PKC inhibitors such as Ro 31-8425 (bisindolylmaleimide X hydrochloride) or staurosporine abolished that protection, and activation of PKC by TPA was an early event that occurs prior to the developing toxicity.	Tetradecanoylphorbol Acetate	25-28	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	32-38
15494549-8	2005	The protective effect of TPA on CYP2E1-dependent AA + Fe toxicity seemed to involve a PKC-related survival mechanism, since PKC inhibitors such as Ro 31-8425 (bisindolylmaleimide X hydrochloride) or staurosporine abolished that protection, and activation of PKC by TPA was an early event that occurs prior to the developing toxicity.	Tetradecanoylphorbol Acetate	265-268	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	32-38
15494549-9	2005	In conclusion, PKC activation by TPA prevents CYP2E1-derived acute oxidative stress and toxicity in HepG2 cells, and this appears to involve maintenance of the intracellular redox homeostasis via PKC signal transduction.	Tetradecanoylphorbol Acetate	33-36	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	46-52
15611126-6	2005	Knockdown of PKCepsilon alone had no effect, but simultaneous knockdown of both PKCalpha and PKCepsilon in C4-2 cells that continued to express normal levels of PKCdelta inhibited PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	180-183	protein kinase C alpha	Homo sapiens	80-88
15611126-8	2005	Investigation of PMA-induced events required for LNCaP and C4-2 apoptosis revealed that p38 activation is dependent on PKCdelta, whereas induction of retinoblastoma protein hypophosphorylation requires both PKC signaling pathways and is downstream of p38 activation in the PKCdelta pathway.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase 14	Homo sapiens	251-254
15591048-7	2005	The TPA treatment induced phosphorylation of surface BGT1 on serine and threonine residues.	Tetradecanoylphorbol Acetate	4-7	solute carrier family 6 member 12	Canis lupus familiaris	53-57
15611126-8	2005	Investigation of PMA-induced events required for LNCaP and C4-2 apoptosis revealed that p38 activation is dependent on PKCdelta, whereas induction of retinoblastoma protein hypophosphorylation requires both PKC signaling pathways and is downstream of p38 activation in the PKCdelta pathway.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase 14	Homo sapiens	88-91
15735027-4	2005	To investigate the possibility that a timed administration of SOD following apoptosis but before proliferation may lead to suppression of tumor incidence, we applied a SOD mimetic (MnTE-2-PyP(5+)) 12 hours after each TPA treatment.	Tetradecanoylphorbol Acetate	217-220	superoxide dismutase 2, mitochondrial	Mus musculus	62-65
15664395-8	2005	PMA-induced Cox-2 expression involves a small GTPase-dependent pathway acting via tyrosine kinase, activation of protein kinase C (PKC) and of the mitogen-activated protein kinase (MAPK) ERK1/2.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Homo sapiens	12-17
15664395-8	2005	PMA-induced Cox-2 expression involves a small GTPase-dependent pathway acting via tyrosine kinase, activation of protein kinase C (PKC) and of the mitogen-activated protein kinase (MAPK) ERK1/2.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	181-185
15664395-8	2005	PMA-induced Cox-2 expression involves a small GTPase-dependent pathway acting via tyrosine kinase, activation of protein kinase C (PKC) and of the mitogen-activated protein kinase (MAPK) ERK1/2.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	187-193
15694920-6	2005	Pressure application of the PKC activator phorbol 12-myristate 13-acetate (PMA) onto angiotensin II-sensitive neurons in the AHA of Wistar rats increased their firing rate.	Tetradecanoylphorbol Acetate	42-73	angiotensinogen	Rattus norvegicus	85-99
15563463-3	2005	Although Mock-transfected K562 cells underwent megakaryocytic differentiation in response to 12-O-tetradecanoylphorbol-13-acetate (TPA), estradiol-activated Notch1/ER induced apoptosis during TPA treatment in the transfectant, which was accompanied by the reduced expression of an antiapoptotic molecule Bcl-XL.	Tetradecanoylphorbol Acetate	192-195	notch receptor 1	Homo sapiens	157-163
15563463-4	2005	Even when apoptosis was prevented by the overexpression of Bcl-XL, activated Notch signals still inhibited TPA-induced megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	107-110	BCL2 like 1	Homo sapiens	59-65
15563463-4	2005	Even when apoptosis was prevented by the overexpression of Bcl-XL, activated Notch signals still inhibited TPA-induced megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	107-110	notch receptor 1	Homo sapiens	77-82
15572354-3	2005	Inhibition of PKC with GF109203X, Go6983, or Go6976 and down-regulation of PKC activity enhanced the release of Ca2+ from internal stores in response to the polyvalent cationic CaR agonist neomycin, whereas activation of PKC with acute 12-O-tetradecanoylphorbol-13-acetate treatment decreased the release.	Tetradecanoylphorbol Acetate	236-272	proline rich transmembrane protein 2	Homo sapiens	75-78
15613696-5	2005	The effect of BAY 43-9006 on phorbol myristate acetate-stimulated ERK phosphorylation in peripheral blood lymphocytes was studied using flow cytometry.	Tetradecanoylphorbol Acetate	29-54	mitogen-activated protein kinase 1	Homo sapiens	66-69
15613696-10	2005	Significant decreases of phorbol myristate acetate-stimulated ERK phosphorylation (P &lt; .01) were identified at doses &gt;/= 200 mg bid continuous.	Tetradecanoylphorbol Acetate	25-50	mitogen-activated protein kinase 1	Homo sapiens	62-65
15652280-5	2005	When CYSST (1mg/ml) was added, the production of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8 was significantly inhibited about 37, 33.6, and 48%, respectively on phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	176-207	tumor necrosis factor	Homo sapiens	49-76
15652280-5	2005	When CYSST (1mg/ml) was added, the production of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8 was significantly inhibited about 37, 33.6, and 48%, respectively on phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	176-207	interleukin 6	Homo sapiens	78-96
15543559-7	2005	Moreover, forskolin reduced the p38 MAP kinase phosphorylation induced by the 12-O-tetradecanoylphorbol-13-acetate (TPA), a PKC-activating phorbol ester, and significantly suppressed the TPA-stimulated accumulation of HSP27.	Tetradecanoylphorbol Acetate	78-114	mitogen-activated protein kinase 14	Homo sapiens	32-35
15543559-7	2005	Moreover, forskolin reduced the p38 MAP kinase phosphorylation induced by the 12-O-tetradecanoylphorbol-13-acetate (TPA), a PKC-activating phorbol ester, and significantly suppressed the TPA-stimulated accumulation of HSP27.	Tetradecanoylphorbol Acetate	116-119	mitogen-activated protein kinase 14	Homo sapiens	32-35
15572354-3	2005	Inhibition of PKC with GF109203X, Go6983, or Go6976 and down-regulation of PKC activity enhanced the release of Ca2+ from internal stores in response to the polyvalent cationic CaR agonist neomycin, whereas activation of PKC with acute 12-O-tetradecanoylphorbol-13-acetate treatment decreased the release.	Tetradecanoylphorbol Acetate	236-272	proline rich transmembrane protein 2	Homo sapiens	75-78
15572354-5	2005	Prolonged treatment of cells with 12-O-tetradecanoylphorbol-13-acetate effectively down-regulated immunoreactive PKC-alpha but had little effect on the expression of PKC-epsilon.	Tetradecanoylphorbol Acetate	34-70	protein kinase C alpha	Homo sapiens	113-122
15668705-9	2005	Also, the phorbol ester PMA could no longer induce PKCalpha translocation in irradiated cells.	Tetradecanoylphorbol Acetate	24-27	protein kinase C alpha	Homo sapiens	51-59
15694920-6	2005	Pressure application of the PKC activator phorbol 12-myristate 13-acetate (PMA) onto angiotensin II-sensitive neurons in the AHA of Wistar rats increased their firing rate.	Tetradecanoylphorbol Acetate	75-78	angiotensinogen	Rattus norvegicus	85-99
15643055-2	2005	We report that incubation of human coronary artery endothelial cells (HCAEC) with phorbol 12-myristate 13-acetate (PMA) to activate protein kinase C (PKC) resulted in hydrolysis of cellular phospholipids similar to that observed with thrombin stimulation (0.05 IU/ml; 10 min).	Tetradecanoylphorbol Acetate	82-113	coagulation factor II, thrombin	Homo sapiens	234-242
15685366-5	2005	Results revealed that TPA treatment in CNE2 cells could upregulate the expression of "triosephosphate isomerase" and "14-3-3 protein sigma" and downregulate the expression of "reticulocalbin 1 precursor", "nucleophosmin", "mitochondrial matrix protein p1 precursor", and "stathmin".	Tetradecanoylphorbol Acetate	22-25	triosephosphate isomerase 1	Homo sapiens	85-124
15685366-5	2005	Results revealed that TPA treatment in CNE2 cells could upregulate the expression of "triosephosphate isomerase" and "14-3-3 protein sigma" and downregulate the expression of "reticulocalbin 1 precursor", "nucleophosmin", "mitochondrial matrix protein p1 precursor", and "stathmin".	Tetradecanoylphorbol Acetate	22-25	reticulocalbin 1	Homo sapiens	176-192
15709120-1	2005	BACKGROUND AND PURPOSE: The relationship between location of occlusion and clinical outcome is poorly understood in patients receiving intravenous tissue-type plasminogen activator (IV tPA).	Tetradecanoylphorbol Acetate	185-188	plasminogen activator, tissue type	Homo sapiens	147-180
15643055-6	2005	Incubation of HCAEC with PMA (100 nM; 5 min) resulted in increased arachidonic acid release (7.1 +/- 0.3 vs. 1.1 +/- 0.1%) and increased production of lysoplasmenylcholine (1.4 +/- 0.2 vs. 0.6 +/- 0.1 nmol PO4/mg of protein), similar to the responses observed with thrombin stimulation.	Tetradecanoylphorbol Acetate	25-28	coagulation factor II, thrombin	Homo sapiens	265-273
15643055-7	2005	Downregulation of PKC by prolonged exposure to PMA (100 nM; 24 h) completely inhibited thrombin-stimulated increases in arachidonic acid release (7.1 +/- 0.6 to 0.5 +/- 0.1%) and lysoplasmenylcholine production (2.0 +/- 0.1 to 0.2 +/- 0.1 nmol PO4/mg of protein).	Tetradecanoylphorbol Acetate	47-50	coagulation factor II, thrombin	Homo sapiens	87-95
15643055-2	2005	We report that incubation of human coronary artery endothelial cells (HCAEC) with phorbol 12-myristate 13-acetate (PMA) to activate protein kinase C (PKC) resulted in hydrolysis of cellular phospholipids similar to that observed with thrombin stimulation (0.05 IU/ml; 10 min).	Tetradecanoylphorbol Acetate	115-118	coagulation factor II, thrombin	Homo sapiens	234-242
15615861-4	2005	Real-time RT-PCR was used to quantify mRNA expression levels of the NGFI-B family members in human ovarian follicles, corpora lutea and in human granulosa cells after FSH, phorbol ester (TPA) and forskolin treatment.	Tetradecanoylphorbol Acetate	187-190	nuclear receptor subfamily 4 group A member 1	Homo sapiens	68-74
15498788-10	2005	IH-901 pre-treatment inhibited TPA-induced epidermal NF-kappaB DNA binding in mouse skin, which appeared to be mediated by blocking phosphorylation and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	31-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	53-62
15498788-10	2005	IH-901 pre-treatment inhibited TPA-induced epidermal NF-kappaB DNA binding in mouse skin, which appeared to be mediated by blocking phosphorylation and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	31-34	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	178-190
15528304-4	2005	Adiponectin cleavage into several carboxyl-terminal fragments containing the globular domain was observed in the medium of phorbol 12-myristate 13-acetate-stimulated monocytic cell lines THP-1 and U937.	Tetradecanoylphorbol Acetate	123-154	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
15528304-4	2005	Adiponectin cleavage into several carboxyl-terminal fragments containing the globular domain was observed in the medium of phorbol 12-myristate 13-acetate-stimulated monocytic cell lines THP-1 and U937.	Tetradecanoylphorbol Acetate	123-154	GLI family zinc finger 2	Homo sapiens	187-192
15645129-6	2005	Moreover, inhibitors of protein kinase C (PKC), 7-hydroxystaurosporin (UCN-01; 100 nM) and chelerythrine (0.5 microM), significantly decreased HL-60 cell differentiation induced by the combination of TPA and capsaicin.	Tetradecanoylphorbol Acetate	200-203	proline rich transmembrane protein 2	Homo sapiens	24-40
15645129-6	2005	Moreover, inhibitors of protein kinase C (PKC), 7-hydroxystaurosporin (UCN-01; 100 nM) and chelerythrine (0.5 microM), significantly decreased HL-60 cell differentiation induced by the combination of TPA and capsaicin.	Tetradecanoylphorbol Acetate	200-203	proline rich transmembrane protein 2	Homo sapiens	42-45
15645129-7	2005	These results suggest that PKC may be involved in HL-60 cell differentiation induced by TPA in combination with capsaicin.	Tetradecanoylphorbol Acetate	88-91	proline rich transmembrane protein 2	Homo sapiens	27-30
15389577-10	2005	We conclude that PMA-induced membrane ruffling is caused via ARF6-Rac1 and ARF1 pathways operating in parallel and that PLD may be inhibitory.	Tetradecanoylphorbol Acetate	17-20	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	120-123
15661932-1	2005	Protein kinase C (PKC) isoforms are major regulators of cutaneous homeostasis and mediate inflammation in response to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	118-154	protein kinase C alpha	Homo sapiens	18-21
15661932-1	2005	Protein kinase C (PKC) isoforms are major regulators of cutaneous homeostasis and mediate inflammation in response to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	156-159	protein kinase C alpha	Homo sapiens	18-21
15661932-2	2005	We have previously reported that transgenic mice overexpressing PKCalpha in the skin exhibit severe intraepidermal neutrophilic inflammation and keratinocyte apoptosis when treated topically with TPA.	Tetradecanoylphorbol Acetate	196-199	protein kinase C, alpha	Mus musculus	64-72
15654930-7	2005	Moreover, other activators of ERK/MAPK, such as epidermal growth factor and phorbol 12-myristate 13-acetate, mimic the neurotrophic effects of VPA.	Tetradecanoylphorbol Acetate	76-107	mitogen-activated protein kinase 1	Homo sapiens	30-33
15654930-7	2005	Moreover, other activators of ERK/MAPK, such as epidermal growth factor and phorbol 12-myristate 13-acetate, mimic the neurotrophic effects of VPA.	Tetradecanoylphorbol Acetate	76-107	mitogen-activated protein kinase 1	Homo sapiens	34-38
15639488-9	2005	This effect was reversed by the PKC inhibitor Ro-318220 and mimicked by the PKC activator phorbol-12 myristate 13-acetate.	Tetradecanoylphorbol Acetate	90-121	protein kinase C alpha	Homo sapiens	32-35
15639488-9	2005	This effect was reversed by the PKC inhibitor Ro-318220 and mimicked by the PKC activator phorbol-12 myristate 13-acetate.	Tetradecanoylphorbol Acetate	90-121	protein kinase C alpha	Homo sapiens	76-79
15654655-7	2005	In particular, pre-treatment with phorbol 12-myristate 13-acetate (PMA) prevents the nuclear accumulation of FGF-2 and FGFR2 in response to PGF(2alpha).	Tetradecanoylphorbol Acetate	34-65	fibroblast growth factor 2	Homo sapiens	109-114
15654655-7	2005	In particular, pre-treatment with phorbol 12-myristate 13-acetate (PMA) prevents the nuclear accumulation of FGF-2 and FGFR2 in response to PGF(2alpha).	Tetradecanoylphorbol Acetate	67-70	fibroblast growth factor 2	Homo sapiens	109-114
15615861-6	2005	In human granulosa tumour (HGT) cells, the NGFI-B expression increased after TPA, and to a lesser extent, after forskolin treatment.	Tetradecanoylphorbol Acetate	77-80	nuclear receptor subfamily 4 group A member 1	Homo sapiens	43-49
15673968-4	2005	Phorbol 12-myristate 13 acetate (PMA) enhanced PI-9 mRNA expression in the CD8+ T lymphocyte clone and YT-N10 cells prior to GrB mRNA expression.	Tetradecanoylphorbol Acetate	0-31	serpin family B member 9	Homo sapiens	47-51
15705185-6	2005	The effects of IL-1beta, which were reproduced by incubation of PTC with PMA (6.25-100 nmol/L), were blocked by H7 but not by BIM-1.	Tetradecanoylphorbol Acetate	73-76	interleukin 1 beta	Homo sapiens	15-23
15673968-4	2005	Phorbol 12-myristate 13 acetate (PMA) enhanced PI-9 mRNA expression in the CD8+ T lymphocyte clone and YT-N10 cells prior to GrB mRNA expression.	Tetradecanoylphorbol Acetate	33-36	serpin family B member 9	Homo sapiens	47-51
15639337-10	2005	In another study, topical application of TPA induced DNA binding of cyclic AMP response element binding (CREB) protein in mouse skin in vivo, which was abrogated by pretreatment with either CB or DC.	Tetradecanoylphorbol Acetate	41-44	cAMP responsive element binding protein 1	Mus musculus	105-109
15592528-6	2005	Treatment with the phorbol ester (PMA), known to stimulate the TFPI-2 promoter activity, augmented the TFPI-2 expression in cell lines with unmethylated or partially methylated TFPI-2, but failed to induce the expression in cell lines that harbored fully methylated TFPI-2.	Tetradecanoylphorbol Acetate	34-37	tissue factor pathway inhibitor 2	Homo sapiens	63-69
15639337-8	2005	As an underlying mechanism of COX-2 inhibition, these extracts diminished TPA-stimulated catalytic activity of extracellular signal-regulated protein kinase (ERK), which is known to regulate the activation of eukaryotic transcription factors mediating COX-2 induction.	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 1	Mus musculus	111-156
15639337-8	2005	As an underlying mechanism of COX-2 inhibition, these extracts diminished TPA-stimulated catalytic activity of extracellular signal-regulated protein kinase (ERK), which is known to regulate the activation of eukaryotic transcription factors mediating COX-2 induction.	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 1	Mus musculus	158-161
15643507-5	2005	Cells were also treated with phorbol 12-myristate 13-acetate (PMA) to study enhanced MMP and VEGF expression.	Tetradecanoylphorbol Acetate	62-65	vascular endothelial growth factor A	Homo sapiens	93-97
15592528-6	2005	Treatment with the phorbol ester (PMA), known to stimulate the TFPI-2 promoter activity, augmented the TFPI-2 expression in cell lines with unmethylated or partially methylated TFPI-2, but failed to induce the expression in cell lines that harbored fully methylated TFPI-2.	Tetradecanoylphorbol Acetate	34-37	tissue factor pathway inhibitor 2	Homo sapiens	103-109
15592528-6	2005	Treatment with the phorbol ester (PMA), known to stimulate the TFPI-2 promoter activity, augmented the TFPI-2 expression in cell lines with unmethylated or partially methylated TFPI-2, but failed to induce the expression in cell lines that harbored fully methylated TFPI-2.	Tetradecanoylphorbol Acetate	34-37	tissue factor pathway inhibitor 2	Homo sapiens	103-109
15592528-6	2005	Treatment with the phorbol ester (PMA), known to stimulate the TFPI-2 promoter activity, augmented the TFPI-2 expression in cell lines with unmethylated or partially methylated TFPI-2, but failed to induce the expression in cell lines that harbored fully methylated TFPI-2.	Tetradecanoylphorbol Acetate	34-37	tissue factor pathway inhibitor 2	Homo sapiens	103-109
18095109-6	2005	Moreover, antisense oligonucleotides and curcumin inhibited phorbol-12-myristate-13-acetate (PMA)-induced RelA/NF-kappaB expression or activation (or both), down-regulated u-PA expression, and reduced the migration and invasive potentials of T98G glioma cells.	Tetradecanoylphorbol Acetate	60-91	nuclear factor kappa B subunit 1	Homo sapiens	111-120
15455341-8	2005	We also found that topical application of PFE resulted in inhibition of TPA-induced phosphorylation of ERK1/2, p38 and JNK1/2, as well as activation of NF-kappaB and IKKalpha and phosphorylation and degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	72-75	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	214-226
15544855-3	2005	NPY and PYY increased oxidative burst in phorbol myristate acetate (PMA)-stimulated macrophages involving activation of protein kinase C (PKC), and decreased it in zymosan-stimulated cells resembling inhibition of signaling pathways subsequent to binding of zymosan particles for the iC3b fragment receptor on macrophages.	Tetradecanoylphorbol Acetate	41-66	neuropeptide Y	Rattus norvegicus	0-3
15544855-3	2005	NPY and PYY increased oxidative burst in phorbol myristate acetate (PMA)-stimulated macrophages involving activation of protein kinase C (PKC), and decreased it in zymosan-stimulated cells resembling inhibition of signaling pathways subsequent to binding of zymosan particles for the iC3b fragment receptor on macrophages.	Tetradecanoylphorbol Acetate	68-71	neuropeptide Y	Rattus norvegicus	0-3
15642147-4	2005	O2*- production by monocytes stimulated with phorbol myristate acetate (PMA) was quantified by the cytochrome c reduction method.	Tetradecanoylphorbol Acetate	45-70	cytochrome c, somatic	Homo sapiens	99-111
15642147-4	2005	O2*- production by monocytes stimulated with phorbol myristate acetate (PMA) was quantified by the cytochrome c reduction method.	Tetradecanoylphorbol Acetate	72-75	cytochrome c, somatic	Homo sapiens	99-111
15561096-0	2005	Connexin43 synthesis, phosphorylation, and degradation in regulation of transient inhibition of gap junction intercellular communication by the phorbol ester TPA in rat liver epithelial cells.	Tetradecanoylphorbol Acetate	158-161	gap junction protein, alpha 1	Rattus norvegicus	0-10
15561096-4	2005	The data presented suggest that restoration of GJIC during continuous TPA exposure in normal and transformed rat liver epithelial cells is dependent on synthesis of Cx43 protein, as well as the transport of already synthesized Cx43 from intracellular pools to the plasma membrane.	Tetradecanoylphorbol Acetate	70-73	gap junction protein, alpha 1	Rattus norvegicus	165-169
15561096-4	2005	The data presented suggest that restoration of GJIC during continuous TPA exposure in normal and transformed rat liver epithelial cells is dependent on synthesis of Cx43 protein, as well as the transport of already synthesized Cx43 from intracellular pools to the plasma membrane.	Tetradecanoylphorbol Acetate	70-73	gap junction protein, alpha 1	Rattus norvegicus	227-231
15561096-6	2005	Both PKC and MAP kinase is involved in TPA-induced degradation of Cx43 and inhibition of GJIC.	Tetradecanoylphorbol Acetate	39-42	gap junction protein, alpha 1	Rattus norvegicus	66-70
15561096-8	2005	Together, the present data highlight Cx43 degradation and synthesis as critical determinants in TPA-induced modifications of cell-cell communication via gap junctions.	Tetradecanoylphorbol Acetate	96-99	gap junction protein, alpha 1	Rattus norvegicus	37-41
15588914-3	2005	DON (62.5-500 ng/ml) also significantly upregulated IL-2 and IL-8 production following prestimulation with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	107-132	interleukin 2	Homo sapiens	52-56
15588914-3	2005	DON (62.5-500 ng/ml) also significantly upregulated IL-2 and IL-8 production following prestimulation with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	107-132	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
15516334-5	2005	The treatment of epidermal cells with the PPAR gamma-specific agonist ciglitazone or azPC augmented cyclooxygenase-2 expression and enzyme activity induced by phorbol 12-myristate-13-acetate or interleukin-1 beta.	Tetradecanoylphorbol Acetate	159-190	peroxisome proliferator activated receptor gamma	Homo sapiens	42-52
15516334-5	2005	The treatment of epidermal cells with the PPAR gamma-specific agonist ciglitazone or azPC augmented cyclooxygenase-2 expression and enzyme activity induced by phorbol 12-myristate-13-acetate or interleukin-1 beta.	Tetradecanoylphorbol Acetate	159-190	prostaglandin-endoperoxide synthase 2	Homo sapiens	100-116
15516334-6	2005	Lipid extracts from the cell homogenate of UVB-irradiated, but not control, cells contained a PPAR gamma-agonistic activity identified by reporter assay, and this activity up-regulated cyclooxygenase-2 expression induced by phorbol 12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	224-255	peroxisome proliferator activated receptor gamma	Homo sapiens	94-104
15516334-6	2005	Lipid extracts from the cell homogenate of UVB-irradiated, but not control, cells contained a PPAR gamma-agonistic activity identified by reporter assay, and this activity up-regulated cyclooxygenase-2 expression induced by phorbol 12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	224-255	prostaglandin-endoperoxide synthase 2	Homo sapiens	185-201
15634764-4	2005	An additive SERT inhibition by PD169316 and beta-phorbol 12-myristate 13-acetate (beta-PMA) indicated the involvement of a protein kinase C (PKC)-independent MAPK pathway.	Tetradecanoylphorbol Acetate	44-80	solute carrier family 6 member 4	Homo sapiens	12-16
15634764-4	2005	An additive SERT inhibition by PD169316 and beta-phorbol 12-myristate 13-acetate (beta-PMA) indicated the involvement of a protein kinase C (PKC)-independent MAPK pathway.	Tetradecanoylphorbol Acetate	82-90	solute carrier family 6 member 4	Homo sapiens	12-16
15634764-9	2005	SERT interaction with protein phosphatase 2A catalytic subunit and syntaxin 1A decreased after PD169316 or beta-PMA treatment of synaptosomes.	Tetradecanoylphorbol Acetate	107-115	solute carrier family 6 member 4	Homo sapiens	0-4
15634764-13	2005	Although PD169316 inhibited SERT insertion to the plasma membrane, beta-PMA increased SERT internalization in HEK-293 cells.	Tetradecanoylphorbol Acetate	67-75	solute carrier family 6 member 4	Homo sapiens	86-90
18095109-6	2005	Moreover, antisense oligonucleotides and curcumin inhibited phorbol-12-myristate-13-acetate (PMA)-induced RelA/NF-kappaB expression or activation (or both), down-regulated u-PA expression, and reduced the migration and invasive potentials of T98G glioma cells.	Tetradecanoylphorbol Acetate	60-91	plasminogen activator, urokinase	Homo sapiens	172-176
18095109-6	2005	Moreover, antisense oligonucleotides and curcumin inhibited phorbol-12-myristate-13-acetate (PMA)-induced RelA/NF-kappaB expression or activation (or both), down-regulated u-PA expression, and reduced the migration and invasive potentials of T98G glioma cells.	Tetradecanoylphorbol Acetate	93-96	nuclear factor kappa B subunit 1	Homo sapiens	111-120
18095109-6	2005	Moreover, antisense oligonucleotides and curcumin inhibited phorbol-12-myristate-13-acetate (PMA)-induced RelA/NF-kappaB expression or activation (or both), down-regulated u-PA expression, and reduced the migration and invasive potentials of T98G glioma cells.	Tetradecanoylphorbol Acetate	93-96	plasminogen activator, urokinase	Homo sapiens	172-176
15671558-6	2005	RESULTS: Frequencies of CD3+ T cells producing IFN-gamma (type 1 T cells) in response to phorbol myristate acetate/ionomycin increased (median, 1.8-fold) in patients receiving IL-2 plus HDC but not in those receiving IL-2 alone (P &lt; 0.01 for comparison between arms).	Tetradecanoylphorbol Acetate	89-114	interferon gamma	Homo sapiens	47-56
15671558-6	2005	RESULTS: Frequencies of CD3+ T cells producing IFN-gamma (type 1 T cells) in response to phorbol myristate acetate/ionomycin increased (median, 1.8-fold) in patients receiving IL-2 plus HDC but not in those receiving IL-2 alone (P &lt; 0.01 for comparison between arms).	Tetradecanoylphorbol Acetate	89-114	interleukin 2	Homo sapiens	176-180
15671558-6	2005	RESULTS: Frequencies of CD3+ T cells producing IFN-gamma (type 1 T cells) in response to phorbol myristate acetate/ionomycin increased (median, 1.8-fold) in patients receiving IL-2 plus HDC but not in those receiving IL-2 alone (P &lt; 0.01 for comparison between arms).	Tetradecanoylphorbol Acetate	89-114	interleukin 2	Homo sapiens	217-221
15618130-9	2005	Furthermore, AIE decreased the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 gene expression and production in human mast cells.	Tetradecanoylphorbol Acetate	31-62	interleukin 6	Homo sapiens	142-155
15583828-10	2005	mRNA for MMP9 as well as plasminogen activator inhibitor-1 (PAI-1) was increased in unstable plaques, while tissue type plasminogen activator (tPA) expression was similar in stable and unstable plaques.	Tetradecanoylphorbol Acetate	143-146	plasminogen activator, tissue type	Homo sapiens	108-141
15618130-9	2005	Furthermore, AIE decreased the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 gene expression and production in human mast cells.	Tetradecanoylphorbol Acetate	64-67	interleukin 6	Homo sapiens	142-155
15574370-8	2005	The carboxyl-terminal lysines of S100A10 bind tPA and plasminogen resulting in the stimulation of tPA-dependent plasmin production.	Tetradecanoylphorbol Acetate	46-49	S100 calcium binding protein A10	Homo sapiens	33-40
15574370-8	2005	The carboxyl-terminal lysines of S100A10 bind tPA and plasminogen resulting in the stimulation of tPA-dependent plasmin production.	Tetradecanoylphorbol Acetate	98-101	S100 calcium binding protein A10	Homo sapiens	33-40
15574370-11	2005	The binding of tPA and plasmin to S100A10 also protects against inhibition by physiological inhibitors, PAI-1 and alpha2-antiplasmin, respectively.	Tetradecanoylphorbol Acetate	15-18	S100 calcium binding protein A10	Homo sapiens	34-41
16463649-4	2005	The differentiation of THP-1 cells into macrophages (MPs) was induced by using myristate acetate (PMA) for 48 h. The macrophages were then incubated with oxidized LDL (ox-LDL) to generate foam cells (FCs).	Tetradecanoylphorbol Acetate	98-101	GLI family zinc finger 2	Homo sapiens	23-28
15917995-0	2005	Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	53-56	protein kinase C alpha	Homo sapiens	14-36
15917995-0	2005	Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	53-56	mitogen-activated protein kinase 1	Homo sapiens	67-70
15917995-2	2005	We have demonstrated that ERK(MAPK) signaling was involved in the induction of both p15(INK4b)and p16(INK4a) CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	201-230	mitogen-activated protein kinase 1	Homo sapiens	26-29
15917995-2	2005	We have demonstrated that ERK(MAPK) signaling was involved in the induction of both p15(INK4b)and p16(INK4a) CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	201-230	cyclin dependent kinase inhibitor 2B	Homo sapiens	84-87
15917995-2	2005	We have demonstrated that ERK(MAPK) signaling was involved in the induction of both p15(INK4b)and p16(INK4a) CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	201-230	cyclin dependent kinase inhibitor 2B	Homo sapiens	88-93
15917995-2	2005	We have demonstrated that ERK(MAPK) signaling was involved in the induction of both p15(INK4b)and p16(INK4a) CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	201-230	cyclin dependent kinase inhibitor 2A	Homo sapiens	98-101
15917995-2	2005	We have demonstrated that ERK(MAPK) signaling was involved in the induction of both p15(INK4b)and p16(INK4a) CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	201-230	cyclin dependent kinase inhibitor 2A	Homo sapiens	102-107
15917995-2	2005	We have demonstrated that ERK(MAPK) signaling was involved in the induction of both p15(INK4b)and p16(INK4a) CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	232-235	mitogen-activated protein kinase 1	Homo sapiens	26-29
15917995-2	2005	We have demonstrated that ERK(MAPK) signaling was involved in the induction of both p15(INK4b)and p16(INK4a) CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	232-235	cyclin dependent kinase inhibitor 2B	Homo sapiens	84-87
15917995-2	2005	We have demonstrated that ERK(MAPK) signaling was involved in the induction of both p15(INK4b)and p16(INK4a) CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	232-235	cyclin dependent kinase inhibitor 2B	Homo sapiens	88-93
15917995-2	2005	We have demonstrated that ERK(MAPK) signaling was involved in the induction of both p15(INK4b)and p16(INK4a) CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	232-235	cyclin dependent kinase inhibitor 2A	Homo sapiens	98-101
15917995-2	2005	We have demonstrated that ERK(MAPK) signaling was involved in the induction of both p15(INK4b)and p16(INK4a) CDK inhibitors and growth inhibition of hepatoma cell HepG2 triggered by the tumor promoter tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	232-235	cyclin dependent kinase inhibitor 2A	Homo sapiens	102-107
15917995-3	2005	In this study, the upstream signal mechanism for TPA-induced ERK(MAPK) activation was investigated.	Tetradecanoylphorbol Acetate	49-52	mitogen-activated protein kinase 1	Homo sapiens	61-64
15917995-4	2005	In HepG2 cells only one of the cPKC isozymes, PKCalpha, but not cPKCbetaII, nPKCepsilon or aPKCzeta was activated by TPA as demonstrated by its membrane translocation within 10-30 min and down-regulation at 24 h after TPA treatment.	Tetradecanoylphorbol Acetate	117-120	protein kinase C alpha	Homo sapiens	46-54
15917995-4	2005	In HepG2 cells only one of the cPKC isozymes, PKCalpha, but not cPKCbetaII, nPKCepsilon or aPKCzeta was activated by TPA as demonstrated by its membrane translocation within 10-30 min and down-regulation at 24 h after TPA treatment.	Tetradecanoylphorbol Acetate	218-221	protein kinase C alpha	Homo sapiens	46-54
15917995-5	2005	Pretreatment of 0.2-2.0 microM Bisindolylmaleimides, an inhibitor of PKC, attenuated the TPA-induced phosphorylation of ERK, gene expressions of p15(INK4b) and p16(INK4a), and growth inhibition of HepG2 cell in a dose-dependent manner.	Tetradecanoylphorbol Acetate	89-92	protein kinase C alpha	Homo sapiens	69-72
15917995-5	2005	Pretreatment of 0.2-2.0 microM Bisindolylmaleimides, an inhibitor of PKC, attenuated the TPA-induced phosphorylation of ERK, gene expressions of p15(INK4b) and p16(INK4a), and growth inhibition of HepG2 cell in a dose-dependent manner.	Tetradecanoylphorbol Acetate	89-92	mitogen-activated protein kinase 1	Homo sapiens	120-123
15917995-5	2005	Pretreatment of 0.2-2.0 microM Bisindolylmaleimides, an inhibitor of PKC, attenuated the TPA-induced phosphorylation of ERK, gene expressions of p15(INK4b) and p16(INK4a), and growth inhibition of HepG2 cell in a dose-dependent manner.	Tetradecanoylphorbol Acetate	89-92	cyclin dependent kinase inhibitor 2B	Homo sapiens	145-148
15917995-5	2005	Pretreatment of 0.2-2.0 microM Bisindolylmaleimides, an inhibitor of PKC, attenuated the TPA-induced phosphorylation of ERK, gene expressions of p15(INK4b) and p16(INK4a), and growth inhibition of HepG2 cell in a dose-dependent manner.	Tetradecanoylphorbol Acetate	89-92	cyclin dependent kinase inhibitor 2B	Homo sapiens	149-154
15917995-5	2005	Pretreatment of 0.2-2.0 microM Bisindolylmaleimides, an inhibitor of PKC, attenuated the TPA-induced phosphorylation of ERK, gene expressions of p15(INK4b) and p16(INK4a), and growth inhibition of HepG2 cell in a dose-dependent manner.	Tetradecanoylphorbol Acetate	89-92	cyclin dependent kinase inhibitor 2A	Homo sapiens	160-163
15917995-5	2005	Pretreatment of 0.2-2.0 microM Bisindolylmaleimides, an inhibitor of PKC, attenuated the TPA-induced phosphorylation of ERK, gene expressions of p15(INK4b) and p16(INK4a), and growth inhibition of HepG2 cell in a dose-dependent manner.	Tetradecanoylphorbol Acetate	89-92	cyclin dependent kinase inhibitor 2A	Homo sapiens	164-169
15917995-7	2005	Taken together, we concluded that PKCalpha is specifically required for TPA-induced ERK(MAPK) signaling to trigger gene expressions of p15(INK4b) and p16(INK4a) leading to HepG2 growth inhibition.	Tetradecanoylphorbol Acetate	72-75	protein kinase C alpha	Homo sapiens	34-42
15917995-7	2005	Taken together, we concluded that PKCalpha is specifically required for TPA-induced ERK(MAPK) signaling to trigger gene expressions of p15(INK4b) and p16(INK4a) leading to HepG2 growth inhibition.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 1	Homo sapiens	84-87
15917995-7	2005	Taken together, we concluded that PKCalpha is specifically required for TPA-induced ERK(MAPK) signaling to trigger gene expressions of p15(INK4b) and p16(INK4a) leading to HepG2 growth inhibition.	Tetradecanoylphorbol Acetate	72-75	cyclin dependent kinase inhibitor 2B	Homo sapiens	135-138
15917995-7	2005	Taken together, we concluded that PKCalpha is specifically required for TPA-induced ERK(MAPK) signaling to trigger gene expressions of p15(INK4b) and p16(INK4a) leading to HepG2 growth inhibition.	Tetradecanoylphorbol Acetate	72-75	cyclin dependent kinase inhibitor 2B	Homo sapiens	139-144
15917995-7	2005	Taken together, we concluded that PKCalpha is specifically required for TPA-induced ERK(MAPK) signaling to trigger gene expressions of p15(INK4b) and p16(INK4a) leading to HepG2 growth inhibition.	Tetradecanoylphorbol Acetate	72-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	150-153
15917995-7	2005	Taken together, we concluded that PKCalpha is specifically required for TPA-induced ERK(MAPK) signaling to trigger gene expressions of p15(INK4b) and p16(INK4a) leading to HepG2 growth inhibition.	Tetradecanoylphorbol Acetate	72-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	154-159
16301841-8	2005	Rp-cAMPS inhibited [3H]ACh release in the presence of phorbol 12-myristate 13-acetate, but PKC inhibition by chelerythrine had no effect on release in the presence of 8-bromo-cyclic AMP.	Tetradecanoylphorbol Acetate	54-85	calmodulin 2, pseudogene 1	Rattus norvegicus	3-8
15968086-11	2005	Moreover, activation of PKC by phorbol 12-myristate 13-acetate markedly attenuated cell death induced by Abeta and induced elevation in BclxL levels.	Tetradecanoylphorbol Acetate	31-62	BCL2 like 1	Homo sapiens	136-141
17150773-6	2005	Our results suggest that miRNAs can be associated with TPA induced signalling pathways and expression of Notch1 gene.	Tetradecanoylphorbol Acetate	55-58	notch receptor 1	Homo sapiens	105-111
15935831-0	2005	The complex between tPA and PAI-1: risk factor for myocardial infarction as studied in the SHEEP project.	Tetradecanoylphorbol Acetate	20-23	plasminogen activator inhibitor 1	Ovis aries	28-33
15496418-8	2004	Furthermore, after treatment of promyelocytic HL-60 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), which triggers differentiation into macrophages, both NMHC-A expression and IRF-2 expression were found to be up-regulated with a similar time course.	Tetradecanoylphorbol Acetate	63-99	myosin heavy chain 9	Homo sapiens	161-167
15496418-8	2004	Furthermore, after treatment of promyelocytic HL-60 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), which triggers differentiation into macrophages, both NMHC-A expression and IRF-2 expression were found to be up-regulated with a similar time course.	Tetradecanoylphorbol Acetate	63-99	interferon regulatory factor 2	Homo sapiens	183-188
15496418-8	2004	Furthermore, after treatment of promyelocytic HL-60 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), which triggers differentiation into macrophages, both NMHC-A expression and IRF-2 expression were found to be up-regulated with a similar time course.	Tetradecanoylphorbol Acetate	101-104	myosin heavy chain 9	Homo sapiens	161-167
15496418-8	2004	Furthermore, after treatment of promyelocytic HL-60 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), which triggers differentiation into macrophages, both NMHC-A expression and IRF-2 expression were found to be up-regulated with a similar time course.	Tetradecanoylphorbol Acetate	101-104	interferon regulatory factor 2	Homo sapiens	183-188
15496418-9	2004	TPA treatment leads to recruitment of IRF-2 to 32kb-150 of the endogenous NMHC-A gene and acetylation of the core histones surrounding this region.	Tetradecanoylphorbol Acetate	0-3	interferon regulatory factor 2	Homo sapiens	38-43
15636703-7	2005	Angiotensin II and phorbol 12-myristate-13-acetate (PMA), the Rho-kinase agonist and PKC agonist, increased the calcium sensitivity, made the cumulative dose-response curve of Ca2+ shift to the left.	Tetradecanoylphorbol Acetate	52-55	angiotensinogen	Rattus norvegicus	0-14
15496418-9	2004	TPA treatment leads to recruitment of IRF-2 to 32kb-150 of the endogenous NMHC-A gene and acetylation of the core histones surrounding this region.	Tetradecanoylphorbol Acetate	0-3	myosin heavy chain 9	Homo sapiens	74-80
15496418-10	2004	In addition, the ISRE in the 32kb-150 reporter gene recruits IRF-2 and mediates TPA-induced activation of a reporter gene in HL-60 cells.	Tetradecanoylphorbol Acetate	80-83	interferon regulatory factor 2	Homo sapiens	61-66
15496418-11	2004	Together, these results indicate that IRF-2 contributes to transcriptional activation of the NMHC-A gene via 32kb-150 during TPA-induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	125-128	interferon regulatory factor 2	Homo sapiens	38-43
15496418-11	2004	Together, these results indicate that IRF-2 contributes to transcriptional activation of the NMHC-A gene via 32kb-150 during TPA-induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	125-128	myosin heavy chain 9	Homo sapiens	93-99
15935831-1	2005	INTRODUCTION: The tPA/PAI-1 complex seems to be an important biochemical marker for myocardial reinfarction.	Tetradecanoylphorbol Acetate	18-21	plasminogen activator inhibitor 1	Ovis aries	22-27
15935831-5	2005	RESULTS: The plasma concentration of tPA/PAI-1 complex was significantly associated with the risk for MI, for both genders.	Tetradecanoylphorbol Acetate	37-40	plasminogen activator inhibitor 1	Ovis aries	41-46
15935831-6	2005	Synergistic interactions were observed in men for the co exposure to high plasma tPA/PAI-1 complex concentrations in combination with smoking (OR=4.6) or diabetes mellitus (OR=7.9).	Tetradecanoylphorbol Acetate	81-84	plasminogen activator inhibitor 1	Ovis aries	85-90
15935831-9	2005	CONCLUSIONS: Measuring the plasma concentration of tPA/PAI-1 complex might be of practical value in assessing risk of MI for both genders, especially in those who are smokers or in patients with manifest diabetes mellitus.	Tetradecanoylphorbol Acetate	51-54	plasminogen activator inhibitor 1	Ovis aries	55-60
15471881-8	2004	In contrast, protein kinase C (PKC) depletion by chronic 12-O-tetradecanoylphorbol-13-acetate treatment nearly abolished UVA-induced ERK and Ras activation.	Tetradecanoylphorbol Acetate	57-93	proline rich transmembrane protein 2	Homo sapiens	13-29
15471881-8	2004	In contrast, protein kinase C (PKC) depletion by chronic 12-O-tetradecanoylphorbol-13-acetate treatment nearly abolished UVA-induced ERK and Ras activation.	Tetradecanoylphorbol Acetate	57-93	proline rich transmembrane protein 2	Homo sapiens	31-34
15471881-8	2004	In contrast, protein kinase C (PKC) depletion by chronic 12-O-tetradecanoylphorbol-13-acetate treatment nearly abolished UVA-induced ERK and Ras activation.	Tetradecanoylphorbol Acetate	57-93	mitogen-activated protein kinase 1	Homo sapiens	133-136
15489897-1	2004	We previously demonstrated that protein kinase C-eta (PKC-eta) mediates a phorbol 12-myristate-13-acetate (PMA)-induced proliferative response in human glioblastoma (GBM) cells.	Tetradecanoylphorbol Acetate	74-105	protein kinase C eta	Homo sapiens	32-52
15491978-3	2004	We have previously shown that hCAT-1-mediated transport is decreased after protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) (Graf, P., Forstermann, U., and Closs, E. I.	Tetradecanoylphorbol Acetate	112-143	proline rich transmembrane protein 2	Homo sapiens	75-91
15491978-3	2004	We have previously shown that hCAT-1-mediated transport is decreased after protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) (Graf, P., Forstermann, U., and Closs, E. I.	Tetradecanoylphorbol Acetate	112-143	proline rich transmembrane protein 2	Homo sapiens	93-96
15491978-3	2004	We have previously shown that hCAT-1-mediated transport is decreased after protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) (Graf, P., Forstermann, U., and Closs, E. I.	Tetradecanoylphorbol Acetate	145-148	proline rich transmembrane protein 2	Homo sapiens	75-91
15491978-3	2004	We have previously shown that hCAT-1-mediated transport is decreased after protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) (Graf, P., Forstermann, U., and Closs, E. I.	Tetradecanoylphorbol Acetate	145-148	proline rich transmembrane protein 2	Homo sapiens	93-96
15541342-4	2004	IL-1alpha, IL-1beta, and TNF-alpha alone had minimal stimulating effects on HGF production in human dermal fibroblasts, but they strongly inhibited production of HGF induced by cholera toxin, 8-bromo-cAMP, EGF, and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	215-246	tumor necrosis factor	Homo sapiens	25-34
15489897-2	2004	In this report, we show that PMA-stimulated activation of PKC-eta in U-251 GBM cells resulted in activation of both Akt and the mammalian target of rapamycin (mTOR) signaling pathways and an increase in cell proliferation.	Tetradecanoylphorbol Acetate	29-32	AKT serine/threonine kinase 1	Homo sapiens	116-119
15489897-2	2004	In this report, we show that PMA-stimulated activation of PKC-eta in U-251 GBM cells resulted in activation of both Akt and the mammalian target of rapamycin (mTOR) signaling pathways and an increase in cell proliferation.	Tetradecanoylphorbol Acetate	29-32	mechanistic target of rapamycin kinase	Homo sapiens	128-157
15489897-1	2004	We previously demonstrated that protein kinase C-eta (PKC-eta) mediates a phorbol 12-myristate-13-acetate (PMA)-induced proliferative response in human glioblastoma (GBM) cells.	Tetradecanoylphorbol Acetate	74-105	protein kinase C eta	Homo sapiens	54-61
15489897-2	2004	In this report, we show that PMA-stimulated activation of PKC-eta in U-251 GBM cells resulted in activation of both Akt and the mammalian target of rapamycin (mTOR) signaling pathways and an increase in cell proliferation.	Tetradecanoylphorbol Acetate	29-32	mechanistic target of rapamycin kinase	Homo sapiens	159-163
15489897-4	2004	Treatment of cells with the PI-3 kinase inhibitor LY294002 (10 muM) or the mTOR inhibitor rapamycin (10 nM) also reduced PMA-induced proliferation and cell-cycle progression.	Tetradecanoylphorbol Acetate	121-124	mechanistic target of rapamycin kinase	Homo sapiens	75-79
15489897-1	2004	We previously demonstrated that protein kinase C-eta (PKC-eta) mediates a phorbol 12-myristate-13-acetate (PMA)-induced proliferative response in human glioblastoma (GBM) cells.	Tetradecanoylphorbol Acetate	107-110	protein kinase C eta	Homo sapiens	32-52
15489897-1	2004	We previously demonstrated that protein kinase C-eta (PKC-eta) mediates a phorbol 12-myristate-13-acetate (PMA)-induced proliferative response in human glioblastoma (GBM) cells.	Tetradecanoylphorbol Acetate	107-110	protein kinase C eta	Homo sapiens	54-61
15489897-2	2004	In this report, we show that PMA-stimulated activation of PKC-eta in U-251 GBM cells resulted in activation of both Akt and the mammalian target of rapamycin (mTOR) signaling pathways and an increase in cell proliferation.	Tetradecanoylphorbol Acetate	29-32	protein kinase C eta	Homo sapiens	58-65
15625014-0	2004	Regulation of alternative splicing of Bcl-x by IL-6, GM-CSF and TPA.	Tetradecanoylphorbol Acetate	64-67	BCL2 like 1	Homo sapiens	38-43
15271671-15	2004	However, AdV-DN PKC-alpha partially blocked PMA-induced ERK activation.	Tetradecanoylphorbol Acetate	44-47	Eph receptor B1	Rattus norvegicus	56-59
15625014-3	2004	In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect.	Tetradecanoylphorbol Acetate	192-228	interleukin 6	Homo sapiens	54-58
15625014-3	2004	In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect.	Tetradecanoylphorbol Acetate	230-233	interleukin 6	Homo sapiens	39-52
15625014-3	2004	In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect.	Tetradecanoylphorbol Acetate	192-228	interleukin 6	Homo sapiens	39-52
15625014-3	2004	In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect.	Tetradecanoylphorbol Acetate	230-233	interleukin 6	Homo sapiens	54-58
15582138-4	2004	Using intracellular staining and flow cytometry, we assessed the ability of freshly isolated liver T cells from these biopsies to produce IFN-gamma, TNF-alpha, IL-2, IL-4, and IL-10 in response to stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	214-217	interferon gamma	Homo sapiens	138-147
15625014-4	2004	In U251 glioma cells, however, TPA efficiently increased the Bcl-xL level.	Tetradecanoylphorbol Acetate	31-34	BCL2 like 1	Homo sapiens	61-67
15625014-7	2004	As for the TPA effect, only nucleotides 1-76 are required in the downstream intron, Thus UK-6, GM-CSF and TPA differentially regulate Bcl-x splicing and require specific intronic pre-mRNA sequences for their respective effects.	Tetradecanoylphorbol Acetate	106-109	BCL2 like 1	Homo sapiens	134-139
15654514-4	2004	RESULTS: HMC-1 produced substantial amounts of GM-CSF and IL-8 and smaller amounts of TNF-alpha, IL-4 and IL-6 after being stimulated with PMA together with A23187.	Tetradecanoylphorbol Acetate	139-142	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
15654514-4	2004	RESULTS: HMC-1 produced substantial amounts of GM-CSF and IL-8 and smaller amounts of TNF-alpha, IL-4 and IL-6 after being stimulated with PMA together with A23187.	Tetradecanoylphorbol Acetate	139-142	tumor necrosis factor	Homo sapiens	86-95
15654514-4	2004	RESULTS: HMC-1 produced substantial amounts of GM-CSF and IL-8 and smaller amounts of TNF-alpha, IL-4 and IL-6 after being stimulated with PMA together with A23187.	Tetradecanoylphorbol Acetate	139-142	interleukin 4	Homo sapiens	97-101
15654514-4	2004	RESULTS: HMC-1 produced substantial amounts of GM-CSF and IL-8 and smaller amounts of TNF-alpha, IL-4 and IL-6 after being stimulated with PMA together with A23187.	Tetradecanoylphorbol Acetate	139-142	interleukin 6	Homo sapiens	106-110
15579770-7	2004	TSHr signal transduction was evaluated by analyzing the effect of stimulators (cholera toxin, 8-bromo-cAMP, forskolin, and 12-O-tetradecanoyl-phorbol-13-acetate) and inhibitors (2",5"-dideoxyadenosine and staurosporine) on VEGF protein levels under basal and TSH-stimulated conditions.	Tetradecanoylphorbol Acetate	123-160	thyroid stimulating hormone receptor	Rattus norvegicus	0-4
15563986-11	2004	On the other hand, treatment with phorbol 12-myristate 13-acetate, another activator of NF-kappaB, also reduced the expression of PPARgamma to 57.8%.	Tetradecanoylphorbol Acetate	34-65	nuclear factor kappa B subunit 1	Homo sapiens	88-97
15563986-11	2004	On the other hand, treatment with phorbol 12-myristate 13-acetate, another activator of NF-kappaB, also reduced the expression of PPARgamma to 57.8%.	Tetradecanoylphorbol Acetate	34-65	peroxisome proliferator activated receptor gamma	Homo sapiens	130-139
15263067-6	2004	CD3/CD28- or phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced p38 and extracellular signal-regulated kinase 1/2 phosphorylation or c-jun NH2-terminal kinase (JNK) 1/2 kinase activity was significantly diminished by pentobarbital, thiamylal, secobarbital, or methohexital treatment.	Tetradecanoylphorbol Acetate	13-44	mitogen-activated protein kinase 14	Homo sapiens	69-72
15569258-6	2004	We provide biochemical and pharmacological evidence that the activity observed after treatment with PMA is mediated by GLAST.	Tetradecanoylphorbol Acetate	100-103	solute carrier family 1 member 3	Homo sapiens	119-124
15263067-6	2004	CD3/CD28- or phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced p38 and extracellular signal-regulated kinase 1/2 phosphorylation or c-jun NH2-terminal kinase (JNK) 1/2 kinase activity was significantly diminished by pentobarbital, thiamylal, secobarbital, or methohexital treatment.	Tetradecanoylphorbol Acetate	13-44	mitogen-activated protein kinase 3	Homo sapiens	77-116
15263067-6	2004	CD3/CD28- or phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced p38 and extracellular signal-regulated kinase 1/2 phosphorylation or c-jun NH2-terminal kinase (JNK) 1/2 kinase activity was significantly diminished by pentobarbital, thiamylal, secobarbital, or methohexital treatment.	Tetradecanoylphorbol Acetate	13-44	mitogen-activated protein kinase 8	Homo sapiens	138-171
15263067-6	2004	CD3/CD28- or phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced p38 and extracellular signal-regulated kinase 1/2 phosphorylation or c-jun NH2-terminal kinase (JNK) 1/2 kinase activity was significantly diminished by pentobarbital, thiamylal, secobarbital, or methohexital treatment.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 14	Homo sapiens	69-72
15263067-6	2004	CD3/CD28- or phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced p38 and extracellular signal-regulated kinase 1/2 phosphorylation or c-jun NH2-terminal kinase (JNK) 1/2 kinase activity was significantly diminished by pentobarbital, thiamylal, secobarbital, or methohexital treatment.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 3	Homo sapiens	77-116
15263067-6	2004	CD3/CD28- or phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced p38 and extracellular signal-regulated kinase 1/2 phosphorylation or c-jun NH2-terminal kinase (JNK) 1/2 kinase activity was significantly diminished by pentobarbital, thiamylal, secobarbital, or methohexital treatment.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 8	Homo sapiens	138-171
15620108-6	2004	The fluorescence of CD18 and CD11b reappeared on the cell membrane 1 h after re-treatment with PMA, suggesting the recycling of non-degraded Mac-1.	Tetradecanoylphorbol Acetate	95-98	integrin subunit beta 2	Homo sapiens	20-24
15489017-4	2004	Additionally, mTRPV1 was activated by either low pH or with addition of the PKC activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	90-121	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	14-20
15465640-5	2004	Results in this experiment showed that SNL glycoprotein inhibits 12-O-Tetra decanoylphorbol-13-acetate (TPA; 100 nM)-induced DNA-binding activities of NF-kappaB and AP-1, and enhances NO production in MCF-7 cells.	Tetradecanoylphorbol Acetate	104-107	nuclear factor kappa B subunit 1	Homo sapiens	151-160
15465640-5	2004	Results in this experiment showed that SNL glycoprotein inhibits 12-O-Tetra decanoylphorbol-13-acetate (TPA; 100 nM)-induced DNA-binding activities of NF-kappaB and AP-1, and enhances NO production in MCF-7 cells.	Tetradecanoylphorbol Acetate	104-107	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	165-169
15475174-6	2004	However, pre-incubation with the PKC inhibitor GF109203X or PKC down-regulation by the phorbol ester PMA, had minimal or no effect on PBDE-99 or Aroclor 1254-induced cytotoxicity.	Tetradecanoylphorbol Acetate	101-104	protein kinase C alpha	Homo sapiens	60-63
15371442-0	2004	Ubiquitination and down-regulation of gap junction protein connexin-43 in response to 12-O-tetradecanoylphorbol 13-acetate treatment.	Tetradecanoylphorbol Acetate	86-122	gap junction protein, alpha 1	Rattus norvegicus	59-70
15371442-3	2004	In the present study, we show that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) induces ubiquitination of connexin-43 (Cx43) in IAR20 rat liver epithelial cells.	Tetradecanoylphorbol Acetate	69-105	gap junction protein, alpha 1	Rattus norvegicus	138-149
15371442-3	2004	In the present study, we show that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) induces ubiquitination of connexin-43 (Cx43) in IAR20 rat liver epithelial cells.	Tetradecanoylphorbol Acetate	69-105	gap junction protein, alpha 1	Rattus norvegicus	151-155
15371442-3	2004	In the present study, we show that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) induces ubiquitination of connexin-43 (Cx43) in IAR20 rat liver epithelial cells.	Tetradecanoylphorbol Acetate	107-110	gap junction protein, alpha 1	Rattus norvegicus	138-149
15371442-3	2004	In the present study, we show that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) induces ubiquitination of connexin-43 (Cx43) in IAR20 rat liver epithelial cells.	Tetradecanoylphorbol Acetate	107-110	gap junction protein, alpha 1	Rattus norvegicus	151-155
15371442-4	2004	The accelerated ubiquitination of Cx43 in response to TPA occurred concomitantly with Cx43 hyperphosphorylation and inhibition of cell-cell communication via gap junctions.	Tetradecanoylphorbol Acetate	54-57	gap junction protein, alpha 1	Rattus norvegicus	34-38
15371442-4	2004	The accelerated ubiquitination of Cx43 in response to TPA occurred concomitantly with Cx43 hyperphosphorylation and inhibition of cell-cell communication via gap junctions.	Tetradecanoylphorbol Acetate	54-57	gap junction protein, alpha 1	Rattus norvegicus	86-90
15371442-5	2004	The TPA-induced ubiquitination of Cx43 was mediated via protein kinase C and partly involved the mitogen-activated protein kinase pathway.	Tetradecanoylphorbol Acetate	4-7	gap junction protein, alpha 1	Rattus norvegicus	34-38
15371442-9	2004	Evidence is provided that Cx43 is modified by multiple monoubiquitins rather than a polyubiquitin chain in response to TPA.	Tetradecanoylphorbol Acetate	119-122	gap junction protein, alpha 1	Rattus norvegicus	26-30
15371442-10	2004	Moreover, the TPA-induced ubiquitination of Cx43 was blocked by proteasomal inhibitors.	Tetradecanoylphorbol Acetate	14-17	gap junction protein, alpha 1	Rattus norvegicus	44-48
15347675-5	2004	In contrast, cellular treatment with phorbol 12-myristate 13-acetate (PMA), a PKC activator, resulted in an approximately 3-fold increase in D2 DAR phosphorylation.	Tetradecanoylphorbol Acetate	37-68	proline rich transmembrane protein 2	Homo sapiens	78-81
15347675-5	2004	In contrast, cellular treatment with phorbol 12-myristate 13-acetate (PMA), a PKC activator, resulted in an approximately 3-fold increase in D2 DAR phosphorylation.	Tetradecanoylphorbol Acetate	70-73	proline rich transmembrane protein 2	Homo sapiens	78-81
15477007-6	2004	We found that both inhibited the increase in expression of many of the genes, including IL-2 and MKP-2, that were induced early after stimulation of lymphocytes with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	166-191	interleukin 2	Homo sapiens	88-92
15356004-1	2004	Recently we reported that simultaneous treatment of NIH 3T3 cells with the combination of phorbol myristate acetate (PMA) and hydrogen peroxide (H2O2) resulted in synergistic activation of Raf-1 kinase (Lee, M., Petrovics, G., and Anderson, W. B.	Tetradecanoylphorbol Acetate	90-115	zinc fingers and homeoboxes 2	Mus musculus	189-192
15356004-1	2004	Recently we reported that simultaneous treatment of NIH 3T3 cells with the combination of phorbol myristate acetate (PMA) and hydrogen peroxide (H2O2) resulted in synergistic activation of Raf-1 kinase (Lee, M., Petrovics, G., and Anderson, W. B.	Tetradecanoylphorbol Acetate	117-120	zinc fingers and homeoboxes 2	Mus musculus	189-192
15476671-3	2004	In this study, we show that HT inhibits luminol-amplified chemiluminescence of human neutrophils stimulated with N-formyl-methionyl-leucyl-phenylalanine (fMLP), phorbol myristate acetate (PMA) and opsonized zymosan.	Tetradecanoylphorbol Acetate	161-186	formyl peptide receptor 1	Homo sapiens	154-158
15476671-3	2004	In this study, we show that HT inhibits luminol-amplified chemiluminescence of human neutrophils stimulated with N-formyl-methionyl-leucyl-phenylalanine (fMLP), phorbol myristate acetate (PMA) and opsonized zymosan.	Tetradecanoylphorbol Acetate	188-191	formyl peptide receptor 1	Homo sapiens	154-158
15489017-4	2004	Additionally, mTRPV1 was activated by either low pH or with addition of the PKC activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	123-126	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	14-20
15556684-3	2004	Using enzyme-linked immunosorbent assay, we measured unstimulated and concanavalin A/phorbol myristate acetate-stimulated production of interleukin-4 (IL-4), IL-5, IL-10, IL-13 and interferon- gamma (IFN-gamma) by decidual explants from 59 healthy women delivered by unlabored cesarean section and from corresponding CBMCs in 39 of the 59.	Tetradecanoylphorbol Acetate	85-110	interleukin 4	Homo sapiens	136-149
15504748-1	2004	The mechanism of inhibition of eosinophil degranulation by protein kinase C (PKC) was investigated in complement C5a (C5a)-stimulated degranulation of highly purified human eosinophils using the specific PKC activator - phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	220-251	protein kinase C alpha	Homo sapiens	77-80
15504748-1	2004	The mechanism of inhibition of eosinophil degranulation by protein kinase C (PKC) was investigated in complement C5a (C5a)-stimulated degranulation of highly purified human eosinophils using the specific PKC activator - phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	253-256	protein kinase C alpha	Homo sapiens	77-80
15504748-3	2004	The inhibition by PMA, but not histamine, was significantly reversed by the specific, but isoform nonselective, PKC inhibitor Ro 31-8220 (1 microM).	Tetradecanoylphorbol Acetate	18-21	protein kinase C alpha	Homo sapiens	112-115
15504748-6	2004	The cAMP production by PMA, but not histamine, was significantly reversed by Ro 31-8220 (1 microM) and the selective inhibitor of the novel PKCdelta, rottlerin (1-3 microM), but not the selective inhibitor of the classical PKC isoforms, Go 6976 (0.01-0.1 microM).	Tetradecanoylphorbol Acetate	23-26	protein kinase C alpha	Homo sapiens	140-143
15666830-5	2004	TPA but not AII increased the level of the transcription factor JunB in nuclear extracts and the increase was partially abolished by the MEK1 inhibitor PD98059.	Tetradecanoylphorbol Acetate	0-3	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	64-68
15666830-7	2004	Taken together these results suggest that TPA inhibits the AII-dependent activation of CYP11B2 via the p44/42 MAPK signaling pathway leading to an increase of the level of nuclear JunB.	Tetradecanoylphorbol Acetate	42-45	angiotensinogen	Homo sapiens	59-62
15666830-7	2004	Taken together these results suggest that TPA inhibits the AII-dependent activation of CYP11B2 via the p44/42 MAPK signaling pathway leading to an increase of the level of nuclear JunB.	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 3	Homo sapiens	110-114
15666830-7	2004	Taken together these results suggest that TPA inhibits the AII-dependent activation of CYP11B2 via the p44/42 MAPK signaling pathway leading to an increase of the level of nuclear JunB.	Tetradecanoylphorbol Acetate	42-45	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	180-184
15666830-1	2004	We have previously reported that the protein kinase C ligand 12-O-tetradecanoyphorbol-13-acetate (TPA) inhibited the angiotensin II (AII) stimulated CYP11B2 gene expression in the adrenocortical H295R cell line.	Tetradecanoylphorbol Acetate	98-101	angiotensinogen	Homo sapiens	117-131
15666830-1	2004	We have previously reported that the protein kinase C ligand 12-O-tetradecanoyphorbol-13-acetate (TPA) inhibited the angiotensin II (AII) stimulated CYP11B2 gene expression in the adrenocortical H295R cell line.	Tetradecanoylphorbol Acetate	98-101	angiotensinogen	Homo sapiens	133-136
15666830-2	2004	Here we report that TPA increased the level of phospho-p44/42 MAPK but AII did not.	Tetradecanoylphorbol Acetate	20-23	mitogen-activated protein kinase 3	Homo sapiens	62-66
15556684-3	2004	Using enzyme-linked immunosorbent assay, we measured unstimulated and concanavalin A/phorbol myristate acetate-stimulated production of interleukin-4 (IL-4), IL-5, IL-10, IL-13 and interferon- gamma (IFN-gamma) by decidual explants from 59 healthy women delivered by unlabored cesarean section and from corresponding CBMCs in 39 of the 59.	Tetradecanoylphorbol Acetate	85-110	interleukin 4	Homo sapiens	151-155
15556684-3	2004	Using enzyme-linked immunosorbent assay, we measured unstimulated and concanavalin A/phorbol myristate acetate-stimulated production of interleukin-4 (IL-4), IL-5, IL-10, IL-13 and interferon- gamma (IFN-gamma) by decidual explants from 59 healthy women delivered by unlabored cesarean section and from corresponding CBMCs in 39 of the 59.	Tetradecanoylphorbol Acetate	85-110	interleukin 13	Homo sapiens	171-176
15556684-3	2004	Using enzyme-linked immunosorbent assay, we measured unstimulated and concanavalin A/phorbol myristate acetate-stimulated production of interleukin-4 (IL-4), IL-5, IL-10, IL-13 and interferon- gamma (IFN-gamma) by decidual explants from 59 healthy women delivered by unlabored cesarean section and from corresponding CBMCs in 39 of the 59.	Tetradecanoylphorbol Acetate	85-110	interferon gamma	Homo sapiens	181-198
15556684-3	2004	Using enzyme-linked immunosorbent assay, we measured unstimulated and concanavalin A/phorbol myristate acetate-stimulated production of interleukin-4 (IL-4), IL-5, IL-10, IL-13 and interferon- gamma (IFN-gamma) by decidual explants from 59 healthy women delivered by unlabored cesarean section and from corresponding CBMCs in 39 of the 59.	Tetradecanoylphorbol Acetate	85-110	interferon gamma	Homo sapiens	200-209
15479821-2	2004	In this study, we found that TPA up-regulated phosphorylation of p38, a mitogen-activated protein kinase, and activated c-myc mRNA in EBV-positive epithelial GT38 cells.	Tetradecanoylphorbol Acetate	29-32	mitogen-activated protein kinase 14	Homo sapiens	65-68
15522912-6	2004	Treatment of HepG2 cells with CA (100 microg/mL) and CAPE (5 microg/mL) suppressed phorbol 12-myristate 13-acetate (PMA) -induced MMP-9 expression by inhibiting the function of NF-kappaB, but not AP-1.	Tetradecanoylphorbol Acetate	116-119	nuclear factor kappa B subunit 1	Homo sapiens	177-186
15489127-9	2004	The relationship between erosion of the hydrogel and the release of the insulin depended on the erosion process of the hydrogel but differed according to the PMA/PMB ratio.	Tetradecanoylphorbol Acetate	158-161	insulin	Homo sapiens	72-79
15591778-2	2004	Direct activation of protein kinase C (PKC) by phorbol-12-myristate-13-acetate (PMA) also stimulates PLD in this tissue.	Tetradecanoylphorbol Acetate	47-78	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	101-104
15591778-2	2004	Direct activation of protein kinase C (PKC) by phorbol-12-myristate-13-acetate (PMA) also stimulates PLD in this tissue.	Tetradecanoylphorbol Acetate	80-83	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	101-104
15591778-5	2004	Both ACh and PMA increased phosphorylation of PLD1 that was significantly blocked by genistein or the PKC inhibitor calphostin C.	Tetradecanoylphorbol Acetate	13-16	phospholipase D1	Homo sapiens	46-50
15591778-7	2004	Western blots probed with an anti-phosphotyrosine antibody indicate that PLD1 in this tissue is phosphorylated on tyrosine residues after ACh or PMA stimulation.	Tetradecanoylphorbol Acetate	145-148	phospholipase D1	Homo sapiens	73-77
15494497-3	2004	Unexpectedly, treating T cells expressing Nef with PMA restored the surface CD4 up to 35% of the steady state level.	Tetradecanoylphorbol Acetate	51-54	S100 calcium binding protein B	Homo sapiens	42-45
15494497-3	2004	Unexpectedly, treating T cells expressing Nef with PMA restored the surface CD4 up to 35% of the steady state level.	Tetradecanoylphorbol Acetate	51-54	CD4 molecule	Homo sapiens	76-79
15539760-4	2004	In transient and stable clones of C12 cells expressing cPLA2alpha, Ca2+ ionophore A23187 and phorbol myristate acetate (PMA) stimulated AA release within 90 min, although no response to TNFalpha was observed within 6 h. These results suggest that C12 cells may lack the components necessary for TNFalpha-induced AA release, in addition to cPLA2alpha.	Tetradecanoylphorbol Acetate	93-118	tumor necrosis factor	Mus musculus	295-303
15539760-4	2004	In transient and stable clones of C12 cells expressing cPLA2alpha, Ca2+ ionophore A23187 and phorbol myristate acetate (PMA) stimulated AA release within 90 min, although no response to TNFalpha was observed within 6 h. These results suggest that C12 cells may lack the components necessary for TNFalpha-induced AA release, in addition to cPLA2alpha.	Tetradecanoylphorbol Acetate	120-123	tumor necrosis factor	Mus musculus	295-303
15479821-9	2004	Our present study demonstrates for the first time that either p38 or c-myc siRNA can efficiently inhibit TPA-induced EBV reactivation in GT38 cells, indicating that p38- and/or c-myc-associated signaling pathways may play critical roles in the disruption of EBV latency by TPA.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase 14	Homo sapiens	165-168
15479821-9	2004	Our present study demonstrates for the first time that either p38 or c-myc siRNA can efficiently inhibit TPA-induced EBV reactivation in GT38 cells, indicating that p38- and/or c-myc-associated signaling pathways may play critical roles in the disruption of EBV latency by TPA.	Tetradecanoylphorbol Acetate	273-276	mitogen-activated protein kinase 14	Homo sapiens	165-168
15479821-5	2004	The p38 inhibitor SB203580 blocked both p38 phosphorylation and ZEBRA expression by TPA.	Tetradecanoylphorbol Acetate	84-87	mitogen-activated protein kinase 14	Homo sapiens	4-7
15479821-9	2004	Our present study demonstrates for the first time that either p38 or c-myc siRNA can efficiently inhibit TPA-induced EBV reactivation in GT38 cells, indicating that p38- and/or c-myc-associated signaling pathways may play critical roles in the disruption of EBV latency by TPA.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase 14	Homo sapiens	62-65
15542774-6	2004	Activation of PKC by phorbol ester (phorbol 12-myristate 13-acetate) enhanced EGF action on ERK1/2 phosphorylation without significantly altering p53 phosphorylation by resveratrol.	Tetradecanoylphorbol Acetate	36-67	protein kinase C alpha	Homo sapiens	14-17
15488737-3	2004	In addition, we showed that this induction is mediated by the PKC pathway: in the presence of Ro 31-8220, an inhibitor of all PKC isozymes, or after 48 h of PMA treatment, Tat protein becomes unable to stimulate IL-10 production.	Tetradecanoylphorbol Acetate	157-160	protein kinase C alpha	Homo sapiens	62-65
15488737-3	2004	In addition, we showed that this induction is mediated by the PKC pathway: in the presence of Ro 31-8220, an inhibitor of all PKC isozymes, or after 48 h of PMA treatment, Tat protein becomes unable to stimulate IL-10 production.	Tetradecanoylphorbol Acetate	157-160	protein kinase C alpha	Homo sapiens	126-129
15542774-6	2004	Activation of PKC by phorbol ester (phorbol 12-myristate 13-acetate) enhanced EGF action on ERK1/2 phosphorylation without significantly altering p53 phosphorylation by resveratrol.	Tetradecanoylphorbol Acetate	36-67	mitogen-activated protein kinase 3	Homo sapiens	92-98
15501252-9	2004	These data suggest that structural elements responsible for COX-1 and COX-2 inhibition do not correlate well with those responsible for inhibiting COX-2 and iNOS gene expression, but elements capable of inhibiting COX-2 and iNOS gene expression also contribute to inhibition of TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	278-281	cytochrome c oxidase I, mitochondrial	Mus musculus	60-65
15501252-9	2004	These data suggest that structural elements responsible for COX-1 and COX-2 inhibition do not correlate well with those responsible for inhibiting COX-2 and iNOS gene expression, but elements capable of inhibiting COX-2 and iNOS gene expression also contribute to inhibition of TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	278-281	nitric oxide synthase 2, inducible	Mus musculus	224-228
15557817-6	2004	Phorbol 12-myristate 13-acetate (PMA), which is known to activate PKC, stimulated PLD activity significantly more in the core protein-transformed cells, in comparison with that of the control cells.	Tetradecanoylphorbol Acetate	33-36	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	82-85
15557817-7	2004	PLD activity assay using PKC isozyme-specific inhibitor and PKC translocation experiment showed that PKC-delta was mainly involved in the PMA- induced PLD activation in the core-transformed cells.	Tetradecanoylphorbol Acetate	138-141	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
15557817-6	2004	Phorbol 12-myristate 13-acetate (PMA), which is known to activate PKC, stimulated PLD activity significantly more in the core protein-transformed cells, in comparison with that of the control cells.	Tetradecanoylphorbol Acetate	0-31	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	82-85
15557817-7	2004	PLD activity assay using PKC isozyme-specific inhibitor and PKC translocation experiment showed that PKC-delta was mainly involved in the PMA- induced PLD activation in the core-transformed cells.	Tetradecanoylphorbol Acetate	138-141	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	151-154
15557821-4	2004	Down-regulation of PKC-alpha with phorbol myristate acetate pretreatment for 24 h abolished Der f 2-induced PLD activation.	Tetradecanoylphorbol Acetate	34-59	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	108-111
15355467-8	2004	Nonspecific stimulus with calcium ionophore and phorbol-myristate-acetate of BM CD34(+) cells caused release of IL-5, IL-3 and GM-CSF.	Tetradecanoylphorbol Acetate	48-73	interleukin 3	Mus musculus	118-122
15258160-7	2004	IRP-1 nitration was strongly reduced when IFN-gamma/LPS/PMA-stimulated cells were incubated with myeloperoxidase inhibitors, which points to the contribution of the nitrite/H2O2/peroxidase pathway to IRP-1 nitration in vivo.	Tetradecanoylphorbol Acetate	56-59	interferon gamma	Mus musculus	42-51
16134003-5	2004	GD (0.01-1 mg/mL)-containing medium in stimulated culture supernatants dose-dependently and significantly decreased IL-8, IL-13, and tumor necrosis factor-alpha secretion on the phorbol 12-myristate 13-acetate and A23187-stimulated HMC-1.	Tetradecanoylphorbol Acetate	178-209	interleukin 13	Homo sapiens	122-160
15281098-7	2004	Moreover, treatment with IL-1alpha as well as phorbol myristate acetate (PMA), a protein kinase C (PKC) activator, or H8, a protein kinase A (PKA) inhibitor, augmented PRL-induced collagenase expression, suggesting that multiple protein kinase pathways and cytokines may participate in PRL-induced collagenase expression.	Tetradecanoylphorbol Acetate	46-71	prolactin, gene 2 L homeolog	Xenopus laevis	168-171
15459838-6	2004	In athletes, 7.9 % of cells responding to non-specific (PMA and ionomycin) stimulation produced IL-2 versus 3.9 % of responding cells in non-athletes (p &lt; 0.05).	Tetradecanoylphorbol Acetate	56-59	interleukin 2	Homo sapiens	96-100
15281098-7	2004	Moreover, treatment with IL-1alpha as well as phorbol myristate acetate (PMA), a protein kinase C (PKC) activator, or H8, a protein kinase A (PKA) inhibitor, augmented PRL-induced collagenase expression, suggesting that multiple protein kinase pathways and cytokines may participate in PRL-induced collagenase expression.	Tetradecanoylphorbol Acetate	46-71	prolactin, gene 2 L homeolog	Xenopus laevis	286-289
15281098-7	2004	Moreover, treatment with IL-1alpha as well as phorbol myristate acetate (PMA), a protein kinase C (PKC) activator, or H8, a protein kinase A (PKA) inhibitor, augmented PRL-induced collagenase expression, suggesting that multiple protein kinase pathways and cytokines may participate in PRL-induced collagenase expression.	Tetradecanoylphorbol Acetate	73-76	prolactin, gene 2 L homeolog	Xenopus laevis	168-171
15281098-7	2004	Moreover, treatment with IL-1alpha as well as phorbol myristate acetate (PMA), a protein kinase C (PKC) activator, or H8, a protein kinase A (PKA) inhibitor, augmented PRL-induced collagenase expression, suggesting that multiple protein kinase pathways and cytokines may participate in PRL-induced collagenase expression.	Tetradecanoylphorbol Acetate	73-76	prolactin, gene 2 L homeolog	Xenopus laevis	286-289
15297452-4	2004	The levels of APOBEC3G mRNA and protein were unaffected by treatment of proliferating H9 cells with interferons or tumor necrosis factor-alpha but were enhanced up to 20-fold by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	178-203	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	14-22
15311213-5	2004	Upon stimulation of normal peripheral blood samples with either phorbol 12-myristate 13 acetate (PMA) plus ionomycin or lipopolysaccharide (LPS), both the number of TNFalpha+ cells and the amount of secreted cytokines progressively increased, the former becoming detectable first.	Tetradecanoylphorbol Acetate	64-95	tumor necrosis factor	Homo sapiens	165-173
15448338-9	2004	When IFN-gamma was present during TPA stimulation, the production of infectious virus was reduced by at least a 60 %, and IFN-alpha fully blocked TPA-induced production of infectious virus.	Tetradecanoylphorbol Acetate	34-37	interferon gamma	Homo sapiens	5-14
15448338-9	2004	When IFN-gamma was present during TPA stimulation, the production of infectious virus was reduced by at least a 60 %, and IFN-alpha fully blocked TPA-induced production of infectious virus.	Tetradecanoylphorbol Acetate	146-149	interferon gamma	Homo sapiens	5-14
15448338-9	2004	When IFN-gamma was present during TPA stimulation, the production of infectious virus was reduced by at least a 60 %, and IFN-alpha fully blocked TPA-induced production of infectious virus.	Tetradecanoylphorbol Acetate	146-149	interferon alpha 1	Homo sapiens	122-131
15324351-8	2004	Tyrosine kinase inhibitor herbimycin A reduced MMP-1 production induced by PMA, whereas the p38 MAPK-inhibitor SB 203580 synergistically increased the stimulatory effect of PMA on both MMP-1 and TIMP-1 production.	Tetradecanoylphorbol Acetate	173-176	mitogen-activated protein kinase 14	Homo sapiens	92-95
15324351-8	2004	Tyrosine kinase inhibitor herbimycin A reduced MMP-1 production induced by PMA, whereas the p38 MAPK-inhibitor SB 203580 synergistically increased the stimulatory effect of PMA on both MMP-1 and TIMP-1 production.	Tetradecanoylphorbol Acetate	173-176	TIMP metallopeptidase inhibitor 1	Homo sapiens	195-201
15311213-5	2004	Upon stimulation of normal peripheral blood samples with either phorbol 12-myristate 13 acetate (PMA) plus ionomycin or lipopolysaccharide (LPS), both the number of TNFalpha+ cells and the amount of secreted cytokines progressively increased, the former becoming detectable first.	Tetradecanoylphorbol Acetate	97-100	tumor necrosis factor	Homo sapiens	165-173
15256533-6	2004	Forskolin plus phorbol myristate acetate also increased promoter activity and, when added to cells cotransfected with PRA, ADAMTS-1 promoter activity increased further.	Tetradecanoylphorbol Acetate	15-40	ADAM metallopeptidase with thrombospondin type 1 motif, 1	Rattus norvegicus	123-131
15337319-4	2004	The obtained results indicate that transcriptional activity of dopamine D2 receptor gene promoter was dose-dependently increased by retinoic acid, forskolin, rolipram and phorbol 12 myristate 13-acetate, as well as by DMI, CIT and MIA.	Tetradecanoylphorbol Acetate	171-202	dopamine receptor D2	Mus musculus	63-83
15271977-8	2004	We examined the function of this Stat5-binding motif by transfecting human peripheral blood mononuclear cells with -3.6 kb of IFNG-luciferase constructs and found that phorbol 12-myristate 13-acetate/ionomycin-induced transcription was augmented by IL-2 treatment.	Tetradecanoylphorbol Acetate	168-199	interferon gamma	Homo sapiens	126-130
15271977-8	2004	We examined the function of this Stat5-binding motif by transfecting human peripheral blood mononuclear cells with -3.6 kb of IFNG-luciferase constructs and found that phorbol 12-myristate 13-acetate/ionomycin-induced transcription was augmented by IL-2 treatment.	Tetradecanoylphorbol Acetate	168-199	interleukin 2	Homo sapiens	249-253
15286717-3	2004	Combined treatment with Ca(2+)-ionophore and phorbol-myristate-acetate (A23187/PMA) increased IL-8 mRNA and protein levels.	Tetradecanoylphorbol Acetate	45-70	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
15215246-4	2004	Transmembrane IL-15Ralpha is constitutively converted into its soluble form by proteolytic cleavage that involves tumor necrosis factor-alpha-converting enzyme (TACE), and this process is further enhanced by phorbol 12-myristate 13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	241-244	a disintegrin and metallopeptidase domain 17	Mus musculus	161-165
15385801-8	2004	In Ca(2+)-independent or -dependent antigen stimulation, although B1 had different inhibitive patterns on CD69 expression stimulated by phorbol 12-myristate 13-acetate (PMA) or Ca2+ ionophore, it inhibited T-cell proliferation induced by CD3/CD28 or PMA/ionomycin and partially blocked that induced by PMA/CD28.	Tetradecanoylphorbol Acetate	136-167	Cd69 molecule	Rattus norvegicus	106-110
15385801-8	2004	In Ca(2+)-independent or -dependent antigen stimulation, although B1 had different inhibitive patterns on CD69 expression stimulated by phorbol 12-myristate 13-acetate (PMA) or Ca2+ ionophore, it inhibited T-cell proliferation induced by CD3/CD28 or PMA/ionomycin and partially blocked that induced by PMA/CD28.	Tetradecanoylphorbol Acetate	169-172	Cd69 molecule	Rattus norvegicus	106-110
15385801-9	2004	Interestingly, an additive inhibition between B1 and tacrolimus (FK506) was found in the CD69 expression stimulated by PMA/CD28 and PMA/ionomycin.	Tetradecanoylphorbol Acetate	119-122	Cd69 molecule	Rattus norvegicus	89-93
15313406-3	2004	In the present study we examined the inhibitory effect of several chemopreventive agents on the tumor necrosis factor (TNF) alpha- or 12-O-tetradecanoylphorbol 13 acetate (TPA)-induced promoter activity of GSTP1-1, as demonstrated by transient transfection experiments in K562 and U937 leukemia cells.	Tetradecanoylphorbol Acetate	172-175	tumor necrosis factor	Homo sapiens	96-117
15313406-4	2004	Our results provide evidence for a differential effect of chemopreventive agents such as beta-lapachone, emodin, sanguinarine and capsaicin, which significantly inhibit reporter gene expression as well as TNFalpha- and TPA-induced binding of AP-1 and NF-kappaB, whereas trans-anethole and silymarin do not produce any inhibitory effect.	Tetradecanoylphorbol Acetate	219-222	nuclear factor kappa B subunit 1	Homo sapiens	251-260
15320911-4	2004	Intracellular expression of interferon (IFN)-gamma, interleukin (IL)-2 and IL-4 in PMA/ionomycin-stimulated peripheral blood mononuclear cells (PBMC) was used to evaluate T helper frequencies.	Tetradecanoylphorbol Acetate	83-86	interleukin 4	Homo sapiens	75-79
15365312-6	2004	Shedding of p75 and p55 TNF receptors (Mono Mac 6 cells) or L-selectin (Jurkat T cells) was induced by stimulation with lipopolysaccharide and phorbol myristate acetate for Mono Mac 6 cells and PMA alone for Jurkat T cells.	Tetradecanoylphorbol Acetate	143-168	tumor necrosis factor	Homo sapiens	24-27
15329596-0	2004	Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro: potential role of the p38-stress kinase pathway.	Tetradecanoylphorbol Acetate	21-46	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-74
15329596-0	2004	Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro: potential role of the p38-stress kinase pathway.	Tetradecanoylphorbol Acetate	21-46	mitogen-activated protein kinase 14	Homo sapiens	141-144
15329596-6	2004	Phorbol-myristate-acetate-dependent effects of sevoflurane on the phosphorylation of the mitogen-activated protein kinases were studied using Western blots, the trans-activating potency of AP-1 was determined using reporter gene assays, and the cytokine release was measured using enzyme-linked immunosorbent assays.	Tetradecanoylphorbol Acetate	0-25	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	189-193
15342392-5	2004	Quantitative reverse transcription-PCR showed that the expression of TEL2 mRNA was down-regulated during monocytic differentiation of U937 and HL60 induced by 1,25-(OH)2 vitamin D3 and 12-O-tetradecanoylphorbol 13-acetate, respectively.	Tetradecanoylphorbol Acetate	185-221	ETS variant transcription factor 7	Homo sapiens	69-73
15350507-6	2004	Median frequencies of IFNgamma+ cells obtained after activation by PMA-ionomycin, PHA or SEA-B were 29.3%, 20.0% and 6.8% for CD4+ cells, and 67.8%, 20.6% and 6.8% for CD8+ cells.	Tetradecanoylphorbol Acetate	67-70	interferon gamma	Homo sapiens	22-30
15286441-13	2004	Furthermore, IJAE decreased the production of TNF-alpha in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated human mast cells.	Tetradecanoylphorbol Acetate	59-90	tumor necrosis factor	Homo sapiens	46-55
15343391-3	2004	The epidermis of Stat3-deficient mice showed a significantly reduced proliferative response following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) because of a defect in G1-to-S-phase cell cycle progression.	Tetradecanoylphorbol Acetate	136-172	signal transducer and activator of transcription 3	Mus musculus	17-22
15343391-3	2004	The epidermis of Stat3-deficient mice showed a significantly reduced proliferative response following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) because of a defect in G1-to-S-phase cell cycle progression.	Tetradecanoylphorbol Acetate	174-177	signal transducer and activator of transcription 3	Mus musculus	17-22
15343391-5	2004	Notably, Stat3-deficient mice were completely resistant to skin tumor development when DMBA was used as the initiator and TPA as the promoter.	Tetradecanoylphorbol Acetate	122-125	signal transducer and activator of transcription 3	Mus musculus	9-14
15304092-6	2004	Furthermore, the differential induction of hBD-2, -3, and -4 gene expression in keratinocytes by proinflammatory cytokines, phorbol-myristate-acetate (PMA), and bacteria was inhibited by more than 90% when the keratinocytes were pre-incubated with RA.	Tetradecanoylphorbol Acetate	124-149	defensin beta 4A	Homo sapiens	43-60
15304092-6	2004	Furthermore, the differential induction of hBD-2, -3, and -4 gene expression in keratinocytes by proinflammatory cytokines, phorbol-myristate-acetate (PMA), and bacteria was inhibited by more than 90% when the keratinocytes were pre-incubated with RA.	Tetradecanoylphorbol Acetate	151-154	defensin beta 4A	Homo sapiens	43-60
15298668-6	2004	Our results show that melatonin increased CaM phosphorylation by PKC alpha with an EC(50) of 10(-8) m in the presence of the phorbol ester, phorbol-12-myristate-13-acetate (PMA) in the in vitro reconstituted enzyme system.	Tetradecanoylphorbol Acetate	140-171	protein kinase C alpha	Homo sapiens	65-74
15298668-6	2004	Our results show that melatonin increased CaM phosphorylation by PKC alpha with an EC(50) of 10(-8) m in the presence of the phorbol ester, phorbol-12-myristate-13-acetate (PMA) in the in vitro reconstituted enzyme system.	Tetradecanoylphorbol Acetate	173-176	protein kinase C alpha	Homo sapiens	65-74
15314167-2	2004	Immunofluorescence analysis demonstrated that activation of PKCalpha by phorbol 12-myristate 13-acetate (PMA), or ectopic expression of constitutively activated PKCalpha, directs AFAP-110 to colocalize with and bind to the c-Src SH3 domain, resulting in activation of the tyrosine kinase.	Tetradecanoylphorbol Acetate	72-103	protein kinase C alpha	Homo sapiens	60-68
15322230-6	2004	Treatment of multidrug-resistant cells with 12-O-tetradecanoylphorbol-13-acetate, a phorbol ester that increases the phosphorylation of P-glycoprotein through activation of protein kinase C, or substituting phosphorylation sites of P-glycoprotein by nonphosphorylatable residues did not affect the ubiquitination of the transporter.	Tetradecanoylphorbol Acetate	44-80	ATP binding cassette subfamily B member 1	Homo sapiens	136-150
15322230-6	2004	Treatment of multidrug-resistant cells with 12-O-tetradecanoylphorbol-13-acetate, a phorbol ester that increases the phosphorylation of P-glycoprotein through activation of protein kinase C, or substituting phosphorylation sites of P-glycoprotein by nonphosphorylatable residues did not affect the ubiquitination of the transporter.	Tetradecanoylphorbol Acetate	44-80	ATP binding cassette subfamily B member 1	Homo sapiens	232-246
15314167-2	2004	Immunofluorescence analysis demonstrated that activation of PKCalpha by phorbol 12-myristate 13-acetate (PMA), or ectopic expression of constitutively activated PKCalpha, directs AFAP-110 to colocalize with and bind to the c-Src SH3 domain, resulting in activation of the tyrosine kinase.	Tetradecanoylphorbol Acetate	105-108	protein kinase C alpha	Homo sapiens	60-68
15292649-5	2004	Phorbol 12-myristate 13-acetate (PMA), lipoteichoic acid (LTA), lipopolysaccharide (LPS) and leukotriene D4 (LTD4) significantly increased MUC2 luciferase activities in the following order: PMA &gt; LTA &gt; LTD4 &gt; LPS.	Tetradecanoylphorbol Acetate	0-31	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	139-143
15292649-5	2004	Phorbol 12-myristate 13-acetate (PMA), lipoteichoic acid (LTA), lipopolysaccharide (LPS) and leukotriene D4 (LTD4) significantly increased MUC2 luciferase activities in the following order: PMA &gt; LTA &gt; LTD4 &gt; LPS.	Tetradecanoylphorbol Acetate	33-36	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	139-143
15178807-0	2004	The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) provokes a prolonged morphologic response and ERK activation in Tsc2-null renal tumor cells.	Tetradecanoylphorbol Acetate	19-55	Eph receptor B1	Rattus norvegicus	108-111
15178807-11	2004	The selective PKC inhibitor, bisindolylmaleimide VIII, however, inhibited TPA-induced changes in morphology and ERK activation.	Tetradecanoylphorbol Acetate	74-77	Eph receptor B1	Rattus norvegicus	112-115
15178807-0	2004	The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) provokes a prolonged morphologic response and ERK activation in Tsc2-null renal tumor cells.	Tetradecanoylphorbol Acetate	57-60	Eph receptor B1	Rattus norvegicus	108-111
15178807-12	2004	These results imply that TPA-induced changes in morphology and ERK activation are mediated primarily through PKC and not Rap1 in renal epithelial cells.	Tetradecanoylphorbol Acetate	25-28	Eph receptor B1	Rattus norvegicus	63-66
15178807-13	2004	These data also imply that Tsc2 expression modulates TPA-induced changes in renal epithelial cell morphology via an ERK-independent mechanism.	Tetradecanoylphorbol Acetate	53-56	Eph receptor B1	Rattus norvegicus	116-119
15178807-9	2004	TPA treatment rapidly increased phosphorylation of ERK, a reported downstream effector of both PKC and Rap1, in ERC-18 cells, but induced weak Rap1 activation.	Tetradecanoylphorbol Acetate	0-3	Eph receptor B1	Rattus norvegicus	51-54
15178807-10	2004	TPA-induced ERK phosphorylation was prolonged in ERC-18 cells compared to NRK-52E cells and expression of Tsc2 in ERC-18 cells did not inhibit prolonged ERK activation.	Tetradecanoylphorbol Acetate	0-3	Eph receptor B1	Rattus norvegicus	12-15
15313895-9	2004	These results contrast sharply with data obtained using the classic 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate cancer model in which a prominent protective effect of COX-1-/- is present.	Tetradecanoylphorbol Acetate	99-135	cytochrome c oxidase I, mitochondrial	Mus musculus	191-196
15271375-5	2004	Simultaneously, the number of lymphocytes producing IL-2 after PMA/ionomycin stimulation was dose dependently reduced (e.g., 24.2% inhibition, p &lt; 0.005, 20 mM vitamin C).	Tetradecanoylphorbol Acetate	63-66	interleukin 2	Homo sapiens	52-56
15358181-3	2004	After the AP-1 inhibition by curcumin analogs in TPA-treated HT-1080 human fibrosarcoma cells, a decrease in mRNA expression of c-jun and MMP3 (stromelysin-1) has been observed.	Tetradecanoylphorbol Acetate	49-52	matrix metallopeptidase 3	Homo sapiens	144-157
15256218-2	2004	Here, we report that protection from NO-induced cell death by phorbol 12-myristate 13-acetate (PMA) is dependent on both p38 and extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	62-93	mitogen-activated protein kinase 1	Homo sapiens	121-124
15256218-2	2004	Here, we report that protection from NO-induced cell death by phorbol 12-myristate 13-acetate (PMA) is dependent on both p38 and extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	62-93	mitogen-activated protein kinase 1	Homo sapiens	129-166
15256218-2	2004	Here, we report that protection from NO-induced cell death by phorbol 12-myristate 13-acetate (PMA) is dependent on both p38 and extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	62-93	mitogen-activated protein kinase 1	Homo sapiens	168-171
15256218-2	2004	Here, we report that protection from NO-induced cell death by phorbol 12-myristate 13-acetate (PMA) is dependent on both p38 and extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 1	Homo sapiens	121-124
15256218-2	2004	Here, we report that protection from NO-induced cell death by phorbol 12-myristate 13-acetate (PMA) is dependent on both p38 and extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 1	Homo sapiens	129-166
15256218-2	2004	Here, we report that protection from NO-induced cell death by phorbol 12-myristate 13-acetate (PMA) is dependent on both p38 and extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 1	Homo sapiens	168-171
15256218-5	2004	In contrast, PMA rapidly phosphorylated both p38 kinase and ERK, and the phosphorylation statuses were not altered in the presence of SNAP.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 1	Homo sapiens	45-48
15256218-5	2004	In contrast, PMA rapidly phosphorylated both p38 kinase and ERK, and the phosphorylation statuses were not altered in the presence of SNAP.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 1	Homo sapiens	60-63
15256218-9	2004	Together, these findings suggest that the PMA-induced activations of ERK and p38 kinase are parallel events that are both required for inhibition of NO-induced death of Molt4 cells.	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 1	Homo sapiens	69-72
15256218-9	2004	Together, these findings suggest that the PMA-induced activations of ERK and p38 kinase are parallel events that are both required for inhibition of NO-induced death of Molt4 cells.	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 1	Homo sapiens	77-80
15627897-4	2004	Here we analyzed the role of AP-1 on the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced human hepatocellular transformation.	Tetradecanoylphorbol Acetate	41-77	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-33
15627897-4	2004	Here we analyzed the role of AP-1 on the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced human hepatocellular transformation.	Tetradecanoylphorbol Acetate	79-82	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-33
15627897-5	2004	TPA promoted the formation of anchorage-independent colonies, induced the AP-1 activity, and enhanced the DNA-binding ability of AP-1 in human hepatocytes.	Tetradecanoylphorbol Acetate	0-3	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-78
15627897-5	2004	TPA promoted the formation of anchorage-independent colonies, induced the AP-1 activity, and enhanced the DNA-binding ability of AP-1 in human hepatocytes.	Tetradecanoylphorbol Acetate	0-3	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	129-133
15627897-6	2004	The phosphorylation of extracellular signal-regulated protein kinases (ERKs) was increased by TPA and the TPA-induced AP-1 activity was inhibited by PD98059, indicating that TPA-induced AP-1 activation was via ERK pathway.	Tetradecanoylphorbol Acetate	94-97	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	186-190
15627897-6	2004	The phosphorylation of extracellular signal-regulated protein kinases (ERKs) was increased by TPA and the TPA-induced AP-1 activity was inhibited by PD98059, indicating that TPA-induced AP-1 activation was via ERK pathway.	Tetradecanoylphorbol Acetate	106-109	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-122
15627897-6	2004	The phosphorylation of extracellular signal-regulated protein kinases (ERKs) was increased by TPA and the TPA-induced AP-1 activity was inhibited by PD98059, indicating that TPA-induced AP-1 activation was via ERK pathway.	Tetradecanoylphorbol Acetate	106-109	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	186-190
15627897-6	2004	The phosphorylation of extracellular signal-regulated protein kinases (ERKs) was increased by TPA and the TPA-induced AP-1 activity was inhibited by PD98059, indicating that TPA-induced AP-1 activation was via ERK pathway.	Tetradecanoylphorbol Acetate	106-109	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-122
15627897-6	2004	The phosphorylation of extracellular signal-regulated protein kinases (ERKs) was increased by TPA and the TPA-induced AP-1 activity was inhibited by PD98059, indicating that TPA-induced AP-1 activation was via ERK pathway.	Tetradecanoylphorbol Acetate	106-109	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	186-190
15627897-7	2004	Moreover, retinoic acid and PD98059, which inhibited the AP-1 activity, abolished the TPA-induced transformation.	Tetradecanoylphorbol Acetate	86-89	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-61
15627897-8	2004	Our findings indicated that AP-1 and ERKs activations were required for TPA-induced human hepatocellular transformation.	Tetradecanoylphorbol Acetate	72-75	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-32
15304658-3	2004	When linked to the murine Ifng gene (-3.4 to +5.6 kb) and transiently transfected into EL-4 cells, these elements clearly enhanced IFN-gamma expression in response to ionomycin and phorbol 12-myristate 13-acetate and weakly enhanced expression in response to T-bet.	Tetradecanoylphorbol Acetate	181-212	interferon gamma	Mus musculus	26-30
15304658-3	2004	When linked to the murine Ifng gene (-3.4 to +5.6 kb) and transiently transfected into EL-4 cells, these elements clearly enhanced IFN-gamma expression in response to ionomycin and phorbol 12-myristate 13-acetate and weakly enhanced expression in response to T-bet.	Tetradecanoylphorbol Acetate	181-212	interferon gamma	Mus musculus	131-140
15321739-3	2004	Phorbol-12-myristate-13-acetate (PMA) and phytohemagglutinin treatment of human pro-monocytic U937 cells increased TNF-alpha protein release.	Tetradecanoylphorbol Acetate	0-31	tumor necrosis factor	Homo sapiens	115-124
15321739-3	2004	Phorbol-12-myristate-13-acetate (PMA) and phytohemagglutinin treatment of human pro-monocytic U937 cells increased TNF-alpha protein release.	Tetradecanoylphorbol Acetate	33-36	tumor necrosis factor	Homo sapiens	115-124
15321739-4	2004	Activation of adenosine receptors up to 1 hr following stimulation with PMA/phytohemagglutinin significantly inhibited TNF-alpha protein release indicating that inhibition of TNF-alpha occurred post-transcriptionally.	Tetradecanoylphorbol Acetate	72-75	tumor necrosis factor	Homo sapiens	119-128
15321739-4	2004	Activation of adenosine receptors up to 1 hr following stimulation with PMA/phytohemagglutinin significantly inhibited TNF-alpha protein release indicating that inhibition of TNF-alpha occurred post-transcriptionally.	Tetradecanoylphorbol Acetate	72-75	tumor necrosis factor	Homo sapiens	175-184
15161907-6	2004	In addition, mangiferin inhibits TNF-induced p65 phosphorylation as well as translocation to the nucleus and also inhibits NF-kappaB activation induced by other inflammatory agents like PMA, ceramide, and SA-LPS.	Tetradecanoylphorbol Acetate	186-189	nuclear factor kappa B subunit 1	Homo sapiens	123-132
15254761-7	2004	LSM showed that HOE642 prevented the PMA-induced disassociation of the zonula adherens molecule beta-catenin from the cell membrane and the decreased expression of the zonula occludens molecule ZO-1.	Tetradecanoylphorbol Acetate	37-40	tight junction protein 1	Homo sapiens	194-198
15289320-3	2004	This cyclopentenone was able to inhibit activator protein1 (AP-1)-dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate (PMA) or c-Jun overexpression.	Tetradecanoylphorbol Acetate	141-172	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
15289320-3	2004	This cyclopentenone was able to inhibit activator protein1 (AP-1)-dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate (PMA) or c-Jun overexpression.	Tetradecanoylphorbol Acetate	141-172	vascular endothelial growth factor A	Homo sapiens	115-119
15289320-3	2004	This cyclopentenone was able to inhibit activator protein1 (AP-1)-dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate (PMA) or c-Jun overexpression.	Tetradecanoylphorbol Acetate	174-177	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
15289320-3	2004	This cyclopentenone was able to inhibit activator protein1 (AP-1)-dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate (PMA) or c-Jun overexpression.	Tetradecanoylphorbol Acetate	174-177	vascular endothelial growth factor A	Homo sapiens	115-119
15289454-1	2004	Pten heterozygous (Pten+/-) mice develop increased papilloma numbers and show decreased carcinoma latency time in comparison with controls after skin treatment with dimethyl benzanthracene (DMBA) and tetradecanoyl-phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	200-229	phosphatase and tensin homolog	Mus musculus	0-4
15289454-1	2004	Pten heterozygous (Pten+/-) mice develop increased papilloma numbers and show decreased carcinoma latency time in comparison with controls after skin treatment with dimethyl benzanthracene (DMBA) and tetradecanoyl-phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	231-234	phosphatase and tensin homolog	Mus musculus	0-4
15212812-5	2004	PD98059 inhibited PGE2 production stimulated by PMA as well as Cd, indicating that activation of PKC by ERK1/2 MAPK was necessary for Cd-stimulated PGE2 production.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 1	Mus musculus	111-115
15270842-7	2004	Phorbol myristate acetate (PMA)-stimulated superoxide production by zymosan-induced peritoneal neutrophils and the levels of zymosan-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta in peritoneal exudate fluids were also reduced in the diabetic mice.	Tetradecanoylphorbol Acetate	0-25	tumor necrosis factor	Mus musculus	141-175
15270842-7	2004	Phorbol myristate acetate (PMA)-stimulated superoxide production by zymosan-induced peritoneal neutrophils and the levels of zymosan-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta in peritoneal exudate fluids were also reduced in the diabetic mice.	Tetradecanoylphorbol Acetate	0-25	interleukin 1 beta	Mus musculus	180-202
15270842-7	2004	Phorbol myristate acetate (PMA)-stimulated superoxide production by zymosan-induced peritoneal neutrophils and the levels of zymosan-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta in peritoneal exudate fluids were also reduced in the diabetic mice.	Tetradecanoylphorbol Acetate	27-30	tumor necrosis factor	Mus musculus	141-175
15270842-7	2004	Phorbol myristate acetate (PMA)-stimulated superoxide production by zymosan-induced peritoneal neutrophils and the levels of zymosan-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta in peritoneal exudate fluids were also reduced in the diabetic mice.	Tetradecanoylphorbol Acetate	27-30	interleukin 1 beta	Mus musculus	180-202
15274135-4	2004	Here, we show that tyrosyl radicals generated by human neutrophils after activation by phorbol 12-myristate 13-acetate (PMA), interferon-gamma (IFN-gamma) or TNF-alpha could act in an autocrine manner by cross-linking to endogenous proteins.	Tetradecanoylphorbol Acetate	87-118	interferon gamma	Homo sapiens	144-153
15252114-6	2004	In the presence of IL-3, PMA dramatically reduced the phosphorylation of residues 31 and 118, which was accompanied by inhibition of cell polarization and motility.	Tetradecanoylphorbol Acetate	25-28	interleukin 3	Mus musculus	19-23
15288477-5	2004	This effect of VEGF was mimicked by phorbol-12-myristate-13-acetate (PMA) and was sensitive to protein kinase C (PKC) inhibition by Go6850.	Tetradecanoylphorbol Acetate	36-67	vascular endothelial growth factor A	Homo sapiens	15-19
15288477-5	2004	This effect of VEGF was mimicked by phorbol-12-myristate-13-acetate (PMA) and was sensitive to protein kinase C (PKC) inhibition by Go6850.	Tetradecanoylphorbol Acetate	69-72	vascular endothelial growth factor A	Homo sapiens	15-19
15276023-5	2004	The expression of Rho-kinase was inhibited by blockades of protein kinase C (PKC) (by either GF109253 or prolonged treatment with phorbol myristate acetate for 24 h) and an adenovirus-mediated gene transfer of dominant-active Ikappa-B, suggesting an involvement of PKC and NF-kappaB in the intracellular signal transduction pathway for the Rho-kinase expression.	Tetradecanoylphorbol Acetate	130-155	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	18-28
15282324-3	2004	We report here that CCND1 promoter activation by estrogens in human breast cancer cells is mediated by recruitment of a c-Jun/c-Fos/estrogen receptor alpha complex to the tetradecanoyl phorbol acetate-responsive element of the gene, together with Oct-1 to a site immediately adjacent.	Tetradecanoylphorbol Acetate	171-200	estrogen receptor 1	Homo sapiens	132-155
15138267-2	2004	The signal link between the BCR and CREB activation depends on a phorbol ester (phorbol 12-myristate 13-acetate)-sensitive protein kinase C (PKC) activity and not protein kinase A or calmodulin kinase; however, the identity and role of the PKC(s) activity has not been elucidated.	Tetradecanoylphorbol Acetate	80-111	cAMP responsive element binding protein 1	Mus musculus	36-40
15235582-3	2004	In the HHV-8-positive PEL cell line BCBL-1, tetradecanoyl phorbol acetate (TPA) induction of the lytic cycle activates the NF-kappaB pathway, and this activation requires the induction of the IKKbeta component of the classical IkappaB kinase (IKK) complex.	Tetradecanoylphorbol Acetate	75-78	nuclear factor kappa B subunit 1	Homo sapiens	123-132
15235582-3	2004	In the HHV-8-positive PEL cell line BCBL-1, tetradecanoyl phorbol acetate (TPA) induction of the lytic cycle activates the NF-kappaB pathway, and this activation requires the induction of the IKKbeta component of the classical IkappaB kinase (IKK) complex.	Tetradecanoylphorbol Acetate	44-73	nuclear factor kappa B subunit 1	Homo sapiens	123-132
15107819-3	2004	We report here that 12-O-tetradecanoylphorbol-13-acetate (TPA), widely used as a protein kinase C (PKC) activator, suppresses the expression of p18(INK4c) through its promoter, accompanied by the induction of human cancer cell growth.	Tetradecanoylphorbol Acetate	58-61	cyclin dependent kinase inhibitor 2C	Homo sapiens	148-153
15194008-7	2004	Moreover, emodin inhibited TPA-induced degradation of inhibitor of kappaBalpha, nuclear translocation of p65, and NF-kappaB DNA-binding activity.	Tetradecanoylphorbol Acetate	27-30	nuclear factor kappa B subunit 1	Homo sapiens	114-123
15252133-6	2004	Activation of PKC in melanocytes increased the level of PKC-beta co-immunoprecipitated with RACK-I, while the level of melanosome-associated RACK-I decreased when melanocytes were treated chronically with the 12-0-tetradecanoyl-phorbol 13-Acetate (TPA), a condition known to deplete PKC and reduce tyrosinase activity.	Tetradecanoylphorbol Acetate	248-251	protein kinase C alpha	Homo sapiens	14-17
15254085-5	2004	Treatment of astrocytes with phorbol 12-myristate 13-acetate (PMA) quickly and preferentially decreases GLT-1 localization on the process membrane, leading to de novo generation of GLT-1 clusters along the process shaft.	Tetradecanoylphorbol Acetate	29-60	solute carrier family 1 member 2	Homo sapiens	104-109
15254085-5	2004	Treatment of astrocytes with phorbol 12-myristate 13-acetate (PMA) quickly and preferentially decreases GLT-1 localization on the process membrane, leading to de novo generation of GLT-1 clusters along the process shaft.	Tetradecanoylphorbol Acetate	29-60	solute carrier family 1 member 2	Homo sapiens	181-186
15254085-5	2004	Treatment of astrocytes with phorbol 12-myristate 13-acetate (PMA) quickly and preferentially decreases GLT-1 localization on the process membrane, leading to de novo generation of GLT-1 clusters along the process shaft.	Tetradecanoylphorbol Acetate	62-65	solute carrier family 1 member 2	Homo sapiens	104-109
15254085-5	2004	Treatment of astrocytes with phorbol 12-myristate 13-acetate (PMA) quickly and preferentially decreases GLT-1 localization on the process membrane, leading to de novo generation of GLT-1 clusters along the process shaft.	Tetradecanoylphorbol Acetate	62-65	solute carrier family 1 member 2	Homo sapiens	181-186
15254085-6	2004	Pretreatment with the PKC inhibitor bisindolylmaleimide II (Bis II), with sucrose (0.4 m), or through the expression of a dominant-negative form of dynamin prevents PMA-induced GLT-1 internalization and cluster formation.	Tetradecanoylphorbol Acetate	165-168	solute carrier family 1 member 2	Homo sapiens	177-182
15254085-7	2004	In terms of glutamate transporter function, PMA treatment elicits a significant decrease in GLT-1 activity that is prevented by preexposure to either Bis II or hypertonic treatment.	Tetradecanoylphorbol Acetate	44-47	solute carrier family 1 member 2	Homo sapiens	92-97
15107819-3	2004	We report here that 12-O-tetradecanoylphorbol-13-acetate (TPA), widely used as a protein kinase C (PKC) activator, suppresses the expression of p18(INK4c) through its promoter, accompanied by the induction of human cancer cell growth.	Tetradecanoylphorbol Acetate	20-56	cyclin dependent kinase inhibitor 2C	Homo sapiens	144-147
15107819-3	2004	We report here that 12-O-tetradecanoylphorbol-13-acetate (TPA), widely used as a protein kinase C (PKC) activator, suppresses the expression of p18(INK4c) through its promoter, accompanied by the induction of human cancer cell growth.	Tetradecanoylphorbol Acetate	20-56	cyclin dependent kinase inhibitor 2C	Homo sapiens	148-153
15107819-3	2004	We report here that 12-O-tetradecanoylphorbol-13-acetate (TPA), widely used as a protein kinase C (PKC) activator, suppresses the expression of p18(INK4c) through its promoter, accompanied by the induction of human cancer cell growth.	Tetradecanoylphorbol Acetate	58-61	cyclin dependent kinase inhibitor 2C	Homo sapiens	144-147
15210597-5	2004	Phorbol 12-myristate 13-acetate, a potent activator of PKC, mimicked the effect of high glucose on VCAM-1 expression.	Tetradecanoylphorbol Acetate	0-31	vascular cell adhesion molecule 1	Homo sapiens	99-105
15107819-4	2004	Reduction of p18(INK4c) using small interfering RNA (siRNA) also enhanced cell growth, suggesting that p18(INK4c) is a critical target of TPA.	Tetradecanoylphorbol Acetate	138-141	cyclin dependent kinase inhibitor 2C	Homo sapiens	13-16
15107819-4	2004	Reduction of p18(INK4c) using small interfering RNA (siRNA) also enhanced cell growth, suggesting that p18(INK4c) is a critical target of TPA.	Tetradecanoylphorbol Acetate	138-141	cyclin dependent kinase inhibitor 2C	Homo sapiens	17-22
15107819-4	2004	Reduction of p18(INK4c) using small interfering RNA (siRNA) also enhanced cell growth, suggesting that p18(INK4c) is a critical target of TPA.	Tetradecanoylphorbol Acetate	138-141	cyclin dependent kinase inhibitor 2C	Homo sapiens	103-106
15107819-4	2004	Reduction of p18(INK4c) using small interfering RNA (siRNA) also enhanced cell growth, suggesting that p18(INK4c) is a critical target of TPA.	Tetradecanoylphorbol Acetate	138-141	cyclin dependent kinase inhibitor 2C	Homo sapiens	107-112
15107819-5	2004	Ro 31-8425, a potent and highly specific PKC inhibitor abrogated the suppressive effect of TPA on p18(INK4c) gene expression.	Tetradecanoylphorbol Acetate	91-94	cyclin dependent kinase inhibitor 2C	Homo sapiens	98-101
15107819-5	2004	Ro 31-8425, a potent and highly specific PKC inhibitor abrogated the suppressive effect of TPA on p18(INK4c) gene expression.	Tetradecanoylphorbol Acetate	91-94	cyclin dependent kinase inhibitor 2C	Homo sapiens	102-107
15201217-9	2004	Pigmentation can be induced, however, by treatment with tetradecanoyl phorbol acetate, which mimics EDNRB signaling, but not by treatment with endothelin 1, which stimulates the paralogous receptor EDNRA.	Tetradecanoylphorbol Acetate	56-85	endothelin receptor type B	Homo sapiens	100-105
15115660-11	2004	The synergistic action of ET-1 with 8-bromo cAMP to enhance glucose transport was inhibited by GF109203X, a selective protein kinase C (PKC) inhibitor, and was mimicked by 4beta-phorbol 12beta-myristate 13alpha-acetate (PMA), a PKC activator.	Tetradecanoylphorbol Acetate	220-223	endothelin 1	Homo sapiens	26-30
15242943-8	2004	As already described for more conventional techniques, we showed that certain genes, such as those for CD40, gamma interferon, interleukin 2 (IL-2), the IL-2 receptor, and tumor necrosis factor alpha, were upregulated in PMA-Iono-stimulated PBMCs.	Tetradecanoylphorbol Acetate	221-224	IL2	Sus scrofa	142-146
15457682-7	2004	Although exposure of cells to prostratin or phorbol-myristate-acetate (PMA) induces the translocation of several PKC isoforms to the plasma membrane, the use of specific PKC inhibitors revealed that novel PKCs are the main mediators of the prostratin-induced CD4 down-regulation, whereas both conventional and novel PKCs contribute to CXCR4 down-regulation.	Tetradecanoylphorbol Acetate	44-69	CD4 molecule	Homo sapiens	259-262
15457682-7	2004	Although exposure of cells to prostratin or phorbol-myristate-acetate (PMA) induces the translocation of several PKC isoforms to the plasma membrane, the use of specific PKC inhibitors revealed that novel PKCs are the main mediators of the prostratin-induced CD4 down-regulation, whereas both conventional and novel PKCs contribute to CXCR4 down-regulation.	Tetradecanoylphorbol Acetate	71-74	CD4 molecule	Homo sapiens	259-262
15213298-3	2004	In Chinese hamster ovary or LN-229 cells heterologously expressing RasGRP3, phorbol 12-myristate 13-acetate (PMA) induced translocation of RasGRP3 to the perinuclear region and a decrease in the electrophoretic mobility of RasGRP3.	Tetradecanoylphorbol Acetate	76-107	RAS guanyl releasing protein 3	Homo sapiens	67-74
15118078-9	2004	A significant decline in the htAKR expression was observed when NEC8, a cell line originated from a human testicular germ cell tumour, was exposed to phorbol 12-myristate 13-acetate or 5alpha-dihydrotestosterone.	Tetradecanoylphorbol Acetate	150-181	aldo-keto reductase family 1 member E2	Homo sapiens	29-34
15213298-3	2004	In Chinese hamster ovary or LN-229 cells heterologously expressing RasGRP3, phorbol 12-myristate 13-acetate (PMA) induced translocation of RasGRP3 to the perinuclear region and a decrease in the electrophoretic mobility of RasGRP3.	Tetradecanoylphorbol Acetate	76-107	RAS guanyl releasing protein 3	Homo sapiens	139-146
15213298-3	2004	In Chinese hamster ovary or LN-229 cells heterologously expressing RasGRP3, phorbol 12-myristate 13-acetate (PMA) induced translocation of RasGRP3 to the perinuclear region and a decrease in the electrophoretic mobility of RasGRP3.	Tetradecanoylphorbol Acetate	76-107	RAS guanyl releasing protein 3	Homo sapiens	139-146
15213298-3	2004	In Chinese hamster ovary or LN-229 cells heterologously expressing RasGRP3, phorbol 12-myristate 13-acetate (PMA) induced translocation of RasGRP3 to the perinuclear region and a decrease in the electrophoretic mobility of RasGRP3.	Tetradecanoylphorbol Acetate	109-112	RAS guanyl releasing protein 3	Homo sapiens	67-74
15213298-3	2004	In Chinese hamster ovary or LN-229 cells heterologously expressing RasGRP3, phorbol 12-myristate 13-acetate (PMA) induced translocation of RasGRP3 to the perinuclear region and a decrease in the electrophoretic mobility of RasGRP3.	Tetradecanoylphorbol Acetate	109-112	RAS guanyl releasing protein 3	Homo sapiens	139-146
15213298-3	2004	In Chinese hamster ovary or LN-229 cells heterologously expressing RasGRP3, phorbol 12-myristate 13-acetate (PMA) induced translocation of RasGRP3 to the perinuclear region and a decrease in the electrophoretic mobility of RasGRP3.	Tetradecanoylphorbol Acetate	109-112	RAS guanyl releasing protein 3	Homo sapiens	139-146
15122342-9	2004	We found that Lupeol treatment to mouse skin resulted in the inhibition of TPA-induced (i) activation of PI3K, (ii) phosphorylation of Akt at Thr(308), (iii) activation of NF-kappaB and IKKalpha, and (iv) degradation and phosphorylation of IkappaBalpha.	Tetradecanoylphorbol Acetate	75-78	thymoma viral proto-oncogene 1	Mus musculus	135-138
15252145-7	2004	However, nobiletin was found to augment the phosphorylation of c-Jun NH2-terminal kinase (JNK), a downstream signal factor of the PI3K-Akt pathway, in TPA-treated HT-1080 cells.	Tetradecanoylphorbol Acetate	151-154	mitogen-activated protein kinase 8	Homo sapiens	63-88
15252145-7	2004	However, nobiletin was found to augment the phosphorylation of c-Jun NH2-terminal kinase (JNK), a downstream signal factor of the PI3K-Akt pathway, in TPA-treated HT-1080 cells.	Tetradecanoylphorbol Acetate	151-154	mitogen-activated protein kinase 8	Homo sapiens	90-93
15252145-7	2004	However, nobiletin was found to augment the phosphorylation of c-Jun NH2-terminal kinase (JNK), a downstream signal factor of the PI3K-Akt pathway, in TPA-treated HT-1080 cells.	Tetradecanoylphorbol Acetate	151-154	AKT serine/threonine kinase 1	Homo sapiens	135-138
15252145-9	2004	Furthermore, nobiletin enhancement of TIMP-1 production in TPA-stimulated HT-1080 cells was found to be diminished by adding a JNK inhibitor, SP600125.	Tetradecanoylphorbol Acetate	59-62	TIMP metallopeptidase inhibitor 1	Homo sapiens	38-44
15252145-9	2004	Furthermore, nobiletin enhancement of TIMP-1 production in TPA-stimulated HT-1080 cells was found to be diminished by adding a JNK inhibitor, SP600125.	Tetradecanoylphorbol Acetate	59-62	mitogen-activated protein kinase 8	Homo sapiens	127-130
15122342-9	2004	We found that Lupeol treatment to mouse skin resulted in the inhibition of TPA-induced (i) activation of PI3K, (ii) phosphorylation of Akt at Thr(308), (iii) activation of NF-kappaB and IKKalpha, and (iv) degradation and phosphorylation of IkappaBalpha.	Tetradecanoylphorbol Acetate	75-78	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	172-181
15122342-9	2004	We found that Lupeol treatment to mouse skin resulted in the inhibition of TPA-induced (i) activation of PI3K, (ii) phosphorylation of Akt at Thr(308), (iii) activation of NF-kappaB and IKKalpha, and (iv) degradation and phosphorylation of IkappaBalpha.	Tetradecanoylphorbol Acetate	75-78	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	240-252
15232218-6	2004	Rottlerin also inhibited PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38MAPK), and the p38 MAPK inhibitor SB203580 inhibited induction of RANK.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase 14	Homo sapiens	56-92
15232218-6	2004	Rottlerin also inhibited PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38MAPK), and the p38 MAPK inhibitor SB203580 inhibited induction of RANK.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase 14	Homo sapiens	94-101
15232218-6	2004	Rottlerin also inhibited PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38MAPK), and the p38 MAPK inhibitor SB203580 inhibited induction of RANK.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase 14	Homo sapiens	56-59
15033986-4	2004	Stimulation of NIH3T3 cells expressing 4 CRUs of AHNAK with phorbol 12-myristate 13-acetate resulted in the increased generation of total inositol phosphates (IP(T)) and mobilization of the intracellular calcium.	Tetradecanoylphorbol Acetate	60-91	AHNAK nucleoprotein (desmoyokin)	Mus musculus	49-54
15188356-2	2004	METHODS: Unstimulated or phytohemagglutinin and phorbol myristate acetate (PHA/PMA)-stimulated PBMCs from 10 RA patients and 12 healthy controls and unstimulated or PHA/PMA-stimulated synovial tissue cells from 8 RA patients were cultured with or without IL-12 (1 ng/ml) and IL-18 (5 ng/ml) alone or in combination.	Tetradecanoylphorbol Acetate	48-73	lamin B receptor	Homo sapiens	75-78
15149680-2	2004	A series of 1-isoquinolinylguanidines are shown to be potent inhibitors of uPA with selectivity over tPA and plasmin.	Tetradecanoylphorbol Acetate	101-104	plasminogen activator, urokinase	Homo sapiens	75-78
15147830-3	2004	The MEK inhibitor U0126 (0.1 to 10 microM) enhanced the TPA-induced ICAM-1 expression but not the IFN-gamma-induced one.	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase kinase 7	Homo sapiens	4-7
15147830-5	2004	Furthermore, PD98059 (0.5 to 50 microM), another MEK inhibitor, enhanced the TPA-induced ICAM-1 expression as well.	Tetradecanoylphorbol Acetate	77-80	mitogen-activated protein kinase kinase 7	Homo sapiens	49-52
15147830-8	2004	TPA partially decreased the level of IkappaB-alpha and the reduction was further augmented by U0126 in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	0-3	NFKB inhibitor alpha	Homo sapiens	37-50
15130280-2	2004	At all selected time points analyzed after TPA treatment, there was more MnSOD immunoreactive protein in mitochondria of keratinocytes of TgH mice than Ntg mice.	Tetradecanoylphorbol Acetate	43-46	superoxide dismutase 2, mitochondrial	Mus musculus	73-78
15075332-1	2004	Previous studies indicated that treatment of cells with 12-O-tetradecanoylphorbol-13-acetate induced phosphorylation of Ser-985 at the juxtamembrane of c-Met, the receptor tyrosine kinase for hepatocyte growth factor (HGF), and this was associated with decreased tyrosine phosphorylation of c-Met.	Tetradecanoylphorbol Acetate	56-92	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	152-157
15075332-1	2004	Previous studies indicated that treatment of cells with 12-O-tetradecanoylphorbol-13-acetate induced phosphorylation of Ser-985 at the juxtamembrane of c-Met, the receptor tyrosine kinase for hepatocyte growth factor (HGF), and this was associated with decreased tyrosine phosphorylation of c-Met.	Tetradecanoylphorbol Acetate	56-92	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	291-296
15155187-6	2004	In THP-1 cells, the level of NF-kappaB nuclear translocation increased fourfold following stimulation with LPS-phorbol myristate acetate (PMA), and this was inhibited (38%) by 10 microg of MXF per ml.	Tetradecanoylphorbol Acetate	111-136	nuclear factor kappa B subunit 1	Homo sapiens	29-38
15155187-6	2004	In THP-1 cells, the level of NF-kappaB nuclear translocation increased fourfold following stimulation with LPS-phorbol myristate acetate (PMA), and this was inhibited (38%) by 10 microg of MXF per ml.	Tetradecanoylphorbol Acetate	138-141	nuclear factor kappa B subunit 1	Homo sapiens	29-38
15135313-2	2004	In this study, we demonstrate that resveratrol enhanced TNF-alpha, IL-12 and IL-1beta production from LPS activated phorbol myristate acetate (PMA) differentiated THP-1 human macrophages.	Tetradecanoylphorbol Acetate	116-141	interleukin 1 beta	Homo sapiens	77-85
15147383-3	2004	Stimulation of the neutrophils with phorbol 12-myristate 13-acetate caused a dramatic increase in the content of CEACAM8 in the light membrane fraction, suggesting a translocation of CEACAM8 to the plasma membrane from intracellular pools.	Tetradecanoylphorbol Acetate	36-67	CEA cell adhesion molecule 8	Homo sapiens	113-120
15147383-3	2004	Stimulation of the neutrophils with phorbol 12-myristate 13-acetate caused a dramatic increase in the content of CEACAM8 in the light membrane fraction, suggesting a translocation of CEACAM8 to the plasma membrane from intracellular pools.	Tetradecanoylphorbol Acetate	36-67	CEA cell adhesion molecule 8	Homo sapiens	183-190
15064752-9	2004	We show that TPA induction of the architectural transcription factor HMGA1 is inhibited by TAM67, is extracellular-signal-regulated kinase (ERK)-activation dependent, and is mediated by AP-1.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 1	Homo sapiens	101-138
15153483-8	2004	The T(CM) were capable of 20-40 mean population doublings in vitro, and the expanded cells produced IFN-gamma, IL-2, and TNF-alpha in response to Ag, and a subset of cells also secreted IL-4 with PMA/ionomycin treatment.	Tetradecanoylphorbol Acetate	196-199	interleukin 4	Homo sapiens	186-190
15149338-10	2004	Phorbol 12-myristate 13-acetate (PMA), indeed, induced an increase in src phosphorylation.	Tetradecanoylphorbol Acetate	0-31	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	70-73
15149338-10	2004	Phorbol 12-myristate 13-acetate (PMA), indeed, induced an increase in src phosphorylation.	Tetradecanoylphorbol Acetate	33-36	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	70-73
15033975-3	2004	The onset of tumor formation, tumor size, and tumor multiplicity induced from a two-stage carcinogen bioassay (7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate) were significantly enhanced in PPARbeta-null mice compared with wild-type mice.	Tetradecanoylphorbol Acetate	142-178	peroxisome proliferator activator receptor delta	Mus musculus	211-219
15047712-8	2004	Treatment of LGI1-expressing cells with phorbol myristate acetate prevents the inhibition of MMP1/3 and restores invasiveness and ERK1/2 phosphorylation, suggesting that LGI1 acts through the ERK/MAPK pathway.	Tetradecanoylphorbol Acetate	40-65	matrix metallopeptidase 13	Homo sapiens	93-99
15047712-8	2004	Treatment of LGI1-expressing cells with phorbol myristate acetate prevents the inhibition of MMP1/3 and restores invasiveness and ERK1/2 phosphorylation, suggesting that LGI1 acts through the ERK/MAPK pathway.	Tetradecanoylphorbol Acetate	40-65	mitogen-activated protein kinase 3	Homo sapiens	130-136
15047712-8	2004	Treatment of LGI1-expressing cells with phorbol myristate acetate prevents the inhibition of MMP1/3 and restores invasiveness and ERK1/2 phosphorylation, suggesting that LGI1 acts through the ERK/MAPK pathway.	Tetradecanoylphorbol Acetate	40-65	mitogen-activated protein kinase 1	Homo sapiens	130-133
15047712-8	2004	Treatment of LGI1-expressing cells with phorbol myristate acetate prevents the inhibition of MMP1/3 and restores invasiveness and ERK1/2 phosphorylation, suggesting that LGI1 acts through the ERK/MAPK pathway.	Tetradecanoylphorbol Acetate	40-65	mitogen-activated protein kinase 3	Homo sapiens	196-200
15064752-9	2004	We show that TPA induction of the architectural transcription factor HMGA1 is inhibited by TAM67, is extracellular-signal-regulated kinase (ERK)-activation dependent, and is mediated by AP-1.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 1	Homo sapiens	140-143
15138488-8	2004	Thus, TPA stimulated c-Jun through JNK, and JIP-1 effectively blocked JNK.	Tetradecanoylphorbol Acetate	6-9	mitogen-activated protein kinase 8	Homo sapiens	35-38
15138488-0	2004	JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	0-25
15138488-9	2004	TPA (10(-12)-10(-8) mol l(-1)) treatment of LNCaP cells caused their growth inhibition, cell cycle arrest, upregulation of p53 and p21waf1, and induction of apoptosis.	Tetradecanoylphorbol Acetate	0-3	tumor protein p53	Homo sapiens	123-126
15138488-0	2004	JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	27-32
15138488-10	2004	All of these effects were significantly attenuated when LNCaP-JIP-1 cells were similarly treated with TPA.	Tetradecanoylphorbol Acetate	102-105	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	62-67
15138488-3	2004	In this study, we found that TPA activates the c-Jun NH2-terminal kinase (JNK)/c-Jun/AP-1 pathway.	Tetradecanoylphorbol Acetate	29-32	mitogen-activated protein kinase 8	Homo sapiens	47-72
15138488-3	2004	In this study, we found that TPA activates the c-Jun NH2-terminal kinase (JNK)/c-Jun/AP-1 pathway.	Tetradecanoylphorbol Acetate	29-32	mitogen-activated protein kinase 8	Homo sapiens	74-77
15138488-13	2004	Contrary to expectation, TPA (10(-9)-10(-8) mol l(-1)) inhibited DHT-induced AREs reporter activity and decreased levels of PSA in the LNCaP-JIP-1 cells.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	141-146
15138488-4	2004	To explore the possible role that the JNK/c-Jun/AP-1 signal pathway has on TPA-induced apoptosis in LNCaP cells, we stably transfected the scaffold protein, JNK interacting protein 1 (JIP-1), which binds to JNK inhibiting its ability to phosphorylate c-Jun.	Tetradecanoylphorbol Acetate	75-78	mitogen-activated protein kinase 8	Homo sapiens	38-41
15138488-14	2004	Taken together, TPA, probably by stimulation of PKC, phosphorylates JNK, which phosphorylates and increases expression of c-Jun leading to AP-1 activity.	Tetradecanoylphorbol Acetate	16-19	mitogen-activated protein kinase 8	Homo sapiens	68-71
15138488-4	2004	To explore the possible role that the JNK/c-Jun/AP-1 signal pathway has on TPA-induced apoptosis in LNCaP cells, we stably transfected the scaffold protein, JNK interacting protein 1 (JIP-1), which binds to JNK inhibiting its ability to phosphorylate c-Jun.	Tetradecanoylphorbol Acetate	75-78	mitogen-activated protein kinase 8	Homo sapiens	157-160
15138488-5	2004	TPA (10(-9)-10(-7) mol l(-1)) caused phosphorylation of JNK in both wild-type and JIP-1-transfected (LNCaP-JIP-1) cells.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	56-59
15138488-5	2004	TPA (10(-9)-10(-7) mol l(-1)) caused phosphorylation of JNK in both wild-type and JIP-1-transfected (LNCaP-JIP-1) cells.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	82-87
15138488-5	2004	TPA (10(-9)-10(-7) mol l(-1)) caused phosphorylation of JNK in both wild-type and JIP-1-transfected (LNCaP-JIP-1) cells.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	107-112
15138488-7	2004	In addition, upregulation of AP-1 reporter activity by TPA (10(-9) mol l(-1)) occurred in LNCaP cells but was abrogated in LNCaP-JIP-1 cells.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	129-134
15118098-5	2004	MORG1 facilitates ERK activation when cells are stimulated with lysophosphatidic acid, phorbol 12-myristate 13-acetate, or serum, but not in response to epidermal growth factor.	Tetradecanoylphorbol Acetate	87-118	WD repeat domain 83	Homo sapiens	0-5
15081395-5	2004	On the contrary, phorbol ester (12-O-tetradecanoylphorbol-13-acetate, TPA)-mediated PLD activity was enhanced by GTPgammaS and was only partially decreased by methyl-beta-cyclodextrin.	Tetradecanoylphorbol Acetate	32-68	plasminogen activator, tissue type	Homo sapiens	70-73
15081395-5	2004	On the contrary, phorbol ester (12-O-tetradecanoylphorbol-13-acetate, TPA)-mediated PLD activity was enhanced by GTPgammaS and was only partially decreased by methyl-beta-cyclodextrin.	Tetradecanoylphorbol Acetate	32-68	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	84-87
15115382-4	2004	A k(app) value in the 10(3) M(-1) s(-1) range for uPA was obtained, together with a selectivity index higher than 240 toward other trypsin-like proteases such as tPA, thrombin, plasmin, and FXa.	Tetradecanoylphorbol Acetate	162-165	plasminogen activator, urokinase	Homo sapiens	50-53
15118098-5	2004	MORG1 facilitates ERK activation when cells are stimulated with lysophosphatidic acid, phorbol 12-myristate 13-acetate, or serum, but not in response to epidermal growth factor.	Tetradecanoylphorbol Acetate	87-118	mitogen-activated protein kinase 1	Homo sapiens	18-21
14695118-7	2004	An activator of PKC-alpha, phorbol 12-myristate 13-acetate, abrogated the activation of l-arginine transport in PAEC treated with PTX.	Tetradecanoylphorbol Acetate	27-58	protein kinase C alpha	Homo sapiens	16-25
14695118-8	2004	Incubation of PTX-treated PAEC with phorbol 12-myristate 13-acetate in combination with an inhibitor of PKC-alpha (Go 6976) restored the activating effects of PTX on l-arginine uptake, suggesting PTX-induced activation of l-arginine transport is mediated through downregulation of PKC-alpha.	Tetradecanoylphorbol Acetate	36-67	protein kinase C alpha	Homo sapiens	281-290
15126366-3	2004	PKC isoforms did show different sensitivity and selectivity for down-regulation by I3A and phorbol 12-myristate 13-acetate (PMA) in WEHI-231, HOP-92, and Colo-205 cells.	Tetradecanoylphorbol Acetate	91-122	protein kinase C, alpha	Mus musculus	0-3
15274349-5	2004	PMA also inhibited the nafoxidine-induced secretion of metalloproteinase-2 and tissue inhibitor of metalloproteinases-1 in HUVEC monolayers.	Tetradecanoylphorbol Acetate	0-3	TIMP metallopeptidase inhibitor 1	Homo sapiens	55-119
15126366-3	2004	PKC isoforms did show different sensitivity and selectivity for down-regulation by I3A and phorbol 12-myristate 13-acetate (PMA) in WEHI-231, HOP-92, and Colo-205 cells.	Tetradecanoylphorbol Acetate	124-127	protein kinase C, alpha	Mus musculus	0-3
15250540-2	2004	The present study tested the hypothesis that lindane and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibit gap junction communication in rat myometrial and liver WBr-F344 cells by the common mechanism of increasing phosphorylation of the gap junction protein connexin43.	Tetradecanoylphorbol Acetate	75-111	gap junction protein, alpha 1	Rattus norvegicus	278-288
14729583-3	2004	In the present work, we found that celecoxib inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of COX-2 in female ICR mouse skin when applied topically 30 min prior to TPA as determined by both immunoblot and immunohistochemical analyses.	Tetradecanoylphorbol Acetate	55-91	prostaglandin-endoperoxide synthase 2	Homo sapiens	120-125
14729583-3	2004	In the present work, we found that celecoxib inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of COX-2 in female ICR mouse skin when applied topically 30 min prior to TPA as determined by both immunoblot and immunohistochemical analyses.	Tetradecanoylphorbol Acetate	93-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	120-125
14729583-7	2004	In order to clarify the roles of p38 and ERK in TPA-induced AP-1 activation, we utilized the pharmacologic inhibitors of these enzymes.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 1	Mus musculus	41-44
14729583-9	2004	Furthermore, SB203580 markedly inhibited COX-2 expression induced by TPA.	Tetradecanoylphorbol Acetate	69-72	prostaglandin-endoperoxide synthase 2	Homo sapiens	41-46
15250540-2	2004	The present study tested the hypothesis that lindane and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibit gap junction communication in rat myometrial and liver WBr-F344 cells by the common mechanism of increasing phosphorylation of the gap junction protein connexin43.	Tetradecanoylphorbol Acetate	113-116	gap junction protein, alpha 1	Rattus norvegicus	278-288
15250540-5	2004	However, TPA increased punctate immunofluorescence staining of phospho-connexin43 (S368) in myometrial cells whereas lindane had no such effect.	Tetradecanoylphorbol Acetate	9-12	gap junction protein, alpha 1	Rattus norvegicus	71-81
15250540-8	2004	TPA intensified a slower migrating connexin43 band and increased phospho-connexin43 (S368) in immunoblots, and intensified phospho-connexin43 immunostaining at WBr-F344 cell interfaces and nuclear regions.	Tetradecanoylphorbol Acetate	0-3	gap junction protein, alpha 1	Rattus norvegicus	35-45
15250540-8	2004	TPA intensified a slower migrating connexin43 band and increased phospho-connexin43 (S368) in immunoblots, and intensified phospho-connexin43 immunostaining at WBr-F344 cell interfaces and nuclear regions.	Tetradecanoylphorbol Acetate	0-3	gap junction protein, alpha 1	Rattus norvegicus	73-83
15250540-8	2004	TPA intensified a slower migrating connexin43 band and increased phospho-connexin43 (S368) in immunoblots, and intensified phospho-connexin43 immunostaining at WBr-F344 cell interfaces and nuclear regions.	Tetradecanoylphorbol Acetate	0-3	gap junction protein, alpha 1	Rattus norvegicus	73-83
14736735-4	2004	ERK activation by GnRH is dependent on protein kinase C (PKC), as evident by activation, inhibition, and depletion of 12-O-tetradecanoylphorbol-13-acetate-sensitive PKC subspecies.	Tetradecanoylphorbol Acetate	118-154	mitogen-activated protein kinase 1	Mus musculus	0-3
15096183-5	2004	The utilization of the PKC inhibitors Go6983, Go6976 and RO-32-0432 demonstrated a role for conventional PKCs (alpha and beta) in the production of TNF-alpha in response to stimulation by lipopolysaccharide and phorbol 12-myristate 13-acetate (PMA)/ionomycin.	Tetradecanoylphorbol Acetate	211-242	tumor necrosis factor	Homo sapiens	148-157
15102766-4	2004	Infection by L. major amastigotes blocked nuclear translocation of a phorbol-12 myristate-13 acetate (PMA)-induced p50/p65 NF-kappaB complex in PMA-treated differentiated U937 cells and triggered expression of p50- and c-Rel-containing complexes in both U937 cells and fresh human monocytes.	Tetradecanoylphorbol Acetate	69-100	nuclear factor kappa B subunit 1	Homo sapiens	115-118
15096183-5	2004	The utilization of the PKC inhibitors Go6983, Go6976 and RO-32-0432 demonstrated a role for conventional PKCs (alpha and beta) in the production of TNF-alpha in response to stimulation by lipopolysaccharide and phorbol 12-myristate 13-acetate (PMA)/ionomycin.	Tetradecanoylphorbol Acetate	244-247	tumor necrosis factor	Homo sapiens	148-157
15102766-4	2004	Infection by L. major amastigotes blocked nuclear translocation of a phorbol-12 myristate-13 acetate (PMA)-induced p50/p65 NF-kappaB complex in PMA-treated differentiated U937 cells and triggered expression of p50- and c-Rel-containing complexes in both U937 cells and fresh human monocytes.	Tetradecanoylphorbol Acetate	69-100	nuclear factor kappa B subunit 1	Homo sapiens	123-132
15102766-4	2004	Infection by L. major amastigotes blocked nuclear translocation of a phorbol-12 myristate-13 acetate (PMA)-induced p50/p65 NF-kappaB complex in PMA-treated differentiated U937 cells and triggered expression of p50- and c-Rel-containing complexes in both U937 cells and fresh human monocytes.	Tetradecanoylphorbol Acetate	69-100	nuclear factor kappa B subunit 1	Homo sapiens	210-213
15102766-4	2004	Infection by L. major amastigotes blocked nuclear translocation of a phorbol-12 myristate-13 acetate (PMA)-induced p50/p65 NF-kappaB complex in PMA-treated differentiated U937 cells and triggered expression of p50- and c-Rel-containing complexes in both U937 cells and fresh human monocytes.	Tetradecanoylphorbol Acetate	102-105	nuclear factor kappa B subunit 1	Homo sapiens	115-118
15102766-4	2004	Infection by L. major amastigotes blocked nuclear translocation of a phorbol-12 myristate-13 acetate (PMA)-induced p50/p65 NF-kappaB complex in PMA-treated differentiated U937 cells and triggered expression of p50- and c-Rel-containing complexes in both U937 cells and fresh human monocytes.	Tetradecanoylphorbol Acetate	102-105	nuclear factor kappa B subunit 1	Homo sapiens	123-132
15102766-4	2004	Infection by L. major amastigotes blocked nuclear translocation of a phorbol-12 myristate-13 acetate (PMA)-induced p50/p65 NF-kappaB complex in PMA-treated differentiated U937 cells and triggered expression of p50- and c-Rel-containing complexes in both U937 cells and fresh human monocytes.	Tetradecanoylphorbol Acetate	102-105	nuclear factor kappa B subunit 1	Homo sapiens	210-213
15296080-3	2004	Human T (Jurkat) cells were cultured in biotin-deficient or biotin-supplemented media; nuclear translocation of NF-kappaB was stimulated with phytohemagglutinin and phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	165-196	nuclear factor kappa B subunit 1	Homo sapiens	112-121
15071347-3	2004	Carvedilol (0.625-5 microM), in a concentration-dependent manner, inhibited basal and vascular endothelial growth factor (VEGF, 0.5 nM) or phorbol 12-myristate 13-acetate (PMA, 10 nM) induced ACE up-regulation.	Tetradecanoylphorbol Acetate	139-170	angiotensin I converting enzyme	Homo sapiens	192-195
15209363-6	2004	IJAE inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells.	Tetradecanoylphorbol Acetate	98-129	tumor necrosis factor	Homo sapiens	32-59
15209363-6	2004	IJAE inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells.	Tetradecanoylphorbol Acetate	98-129	tumor necrosis factor	Homo sapiens	61-70
15209363-6	2004	IJAE inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells.	Tetradecanoylphorbol Acetate	98-129	interleukin 6	Homo sapiens	76-94
15086914-9	2004	Protein kinase C (PKC) inhibition by GF109203X and PKC down-regulation with long-time phorbol myristate acetate (PMA) treatment both inhibited BMK1 and Src kinase activation.	Tetradecanoylphorbol Acetate	86-111	mitogen-activated protein kinase 7	Rattus norvegicus	143-147
15086914-9	2004	Protein kinase C (PKC) inhibition by GF109203X and PKC down-regulation with long-time phorbol myristate acetate (PMA) treatment both inhibited BMK1 and Src kinase activation.	Tetradecanoylphorbol Acetate	113-116	mitogen-activated protein kinase 7	Rattus norvegicus	143-147
15063796-3	2004	Use of a pharmacological inhibitor (U0126) demonstrated that extracellular signal regulated kinase (ERK) plays a major role in TPA-induced MMP-13 gene expression.	Tetradecanoylphorbol Acetate	127-130	mitogen-activated protein kinase 1	Mus musculus	61-98
15161371-4	2004	PMA (phorbol 12-myristate 13-acetate), a PKC activator, inhibited the radiation-induced apoptosis in 3SBH5 cells.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Mus musculus	41-44
15161371-4	2004	PMA (phorbol 12-myristate 13-acetate), a PKC activator, inhibited the radiation-induced apoptosis in 3SBH5 cells.	Tetradecanoylphorbol Acetate	5-36	protein kinase C, alpha	Mus musculus	41-44
15063796-3	2004	Use of a pharmacological inhibitor (U0126) demonstrated that extracellular signal regulated kinase (ERK) plays a major role in TPA-induced MMP-13 gene expression.	Tetradecanoylphorbol Acetate	127-130	mitogen-activated protein kinase 1	Mus musculus	100-103
15063796-6	2004	TPA stimulated ERK-dependent increases in c-Fos protein and the c-Fos content of AP-1 complexes.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Mus musculus	15-18
15094063-6	2004	Furthermore, DHA seems to act by inhibiting PKC activation as this fatty acid diminished TG- and phorbol 12-myristate 13-acetate-induced ERK1/ERK2 phosphorylation in these cells.	Tetradecanoylphorbol Acetate	97-128	mitogen-activated protein kinase 3	Homo sapiens	137-141
15179048-7	2004	In addition, PMA-induction of Lkn-1/CCL15 in transiently transfected U937 cells was blocked by proteasome inhibitor 1.	Tetradecanoylphorbol Acetate	13-16	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	106-117
14769799-4	2004	Phorbol 12-myristate 13-acetate (PMA)-stimulated but not resting neutrophils dissolved fibrin clots, and this activity was not only uPA- and Plg-dependent but also alpha(M)beta(2)-dependent.	Tetradecanoylphorbol Acetate	0-31	plasminogen activator, urokinase	Homo sapiens	132-135
14769799-4	2004	Phorbol 12-myristate 13-acetate (PMA)-stimulated but not resting neutrophils dissolved fibrin clots, and this activity was not only uPA- and Plg-dependent but also alpha(M)beta(2)-dependent.	Tetradecanoylphorbol Acetate	33-36	plasminogen activator, urokinase	Homo sapiens	132-135
15094063-6	2004	Furthermore, DHA seems to act by inhibiting PKC activation as this fatty acid diminished TG- and phorbol 12-myristate 13-acetate-induced ERK1/ERK2 phosphorylation in these cells.	Tetradecanoylphorbol Acetate	97-128	mitogen-activated protein kinase 1	Homo sapiens	142-146
15033458-5	2004	Additionally, Go6983 but not Go6976 inhibited ERK- and JNK-phosphorylation as well as Smad7 promoter activity induced by TPA.	Tetradecanoylphorbol Acetate	121-124	SMAD family member 7	Homo sapiens	86-91
15048868-6	2004	In addition, inhibition of conventional and novel PKC isoforms by chronic (24 h) exposure to phorbol 12-myristate 13-acetate (PMA) inhibited AVP-induced activation of ERK and p70S6 kinase as well as EGF-R phosphorylation.	Tetradecanoylphorbol Acetate	93-124	Eph receptor B1	Rattus norvegicus	167-170
15048868-6	2004	In addition, inhibition of conventional and novel PKC isoforms by chronic (24 h) exposure to phorbol 12-myristate 13-acetate (PMA) inhibited AVP-induced activation of ERK and p70S6 kinase as well as EGF-R phosphorylation.	Tetradecanoylphorbol Acetate	126-129	Eph receptor B1	Rattus norvegicus	167-170
14711835-7	2004	PTD-p65-P1 suppressed NF-kappaB activation induced by lipopolysaccharide, interleukin-1, okadaic acid, phorbol 12-myristate 13-acetate, H(2)O(2), and cigarette smoke condensate as well as that induced by TNF.	Tetradecanoylphorbol Acetate	103-134	nuclear factor kappa B subunit 1	Homo sapiens	22-31
15033458-9	2004	In addition, TPA up-regulated Smad7 expression in the presence of NF-kappaB inhibitor TLCK.	Tetradecanoylphorbol Acetate	13-16	SMAD family member 7	Homo sapiens	30-35
15033458-0	2004	Expressions of inhibitory Smads, Smad6 and Smad7, are differentially regulated by TPA in human lung fibroblast cells.	Tetradecanoylphorbol Acetate	82-85	SMAD family member 7	Homo sapiens	43-48
15033458-2	2004	Here, we show that phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) down-regulates Smad6 mRNA expression and up-regulates Smad7 mRNA expression in IMR-90, a human lung fibroblast cell line.	Tetradecanoylphorbol Acetate	33-69	SMAD family member 7	Homo sapiens	130-135
15033458-2	2004	Here, we show that phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) down-regulates Smad6 mRNA expression and up-regulates Smad7 mRNA expression in IMR-90, a human lung fibroblast cell line.	Tetradecanoylphorbol Acetate	71-74	SMAD family member 7	Homo sapiens	130-135
15033458-9	2004	In addition, TPA up-regulated Smad7 expression in the presence of NF-kappaB inhibitor TLCK.	Tetradecanoylphorbol Acetate	13-16	nuclear factor kappa B subunit 1	Homo sapiens	66-75
15033458-10	2004	These findings indicate that TPA down-regulates Smad6 expression presumably via PKCmu-ERK-dependent pathway and up-regulates Smad7 expression via PKCmu-dependent mechanism(s) which need no MAPK and NF-kappaB activation.	Tetradecanoylphorbol Acetate	29-32	mitogen-activated protein kinase 1	Homo sapiens	86-89
15033458-10	2004	These findings indicate that TPA down-regulates Smad6 expression presumably via PKCmu-ERK-dependent pathway and up-regulates Smad7 expression via PKCmu-dependent mechanism(s) which need no MAPK and NF-kappaB activation.	Tetradecanoylphorbol Acetate	29-32	SMAD family member 7	Homo sapiens	125-130
15033458-10	2004	These findings indicate that TPA down-regulates Smad6 expression presumably via PKCmu-ERK-dependent pathway and up-regulates Smad7 expression via PKCmu-dependent mechanism(s) which need no MAPK and NF-kappaB activation.	Tetradecanoylphorbol Acetate	29-32	nuclear factor kappa B subunit 1	Homo sapiens	198-207
15013844-9	2004	Myeloperoxidase activity of phorbol 12-myristate 13-acetate stimulated HL-60 cells was inhibited by (-)-epicatechin with an IC(50) value of 77.4 microM.	Tetradecanoylphorbol Acetate	28-59	myeloperoxidase	Homo sapiens	0-15
15020229-3	2004	Retinoic acid (RA)-induced differentiation increased PLD1 and PLD2 mRNA levels and PLD activity that was responsive to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	119-144	phospholipase D1	Homo sapiens	53-57
15020229-3	2004	Retinoic acid (RA)-induced differentiation increased PLD1 and PLD2 mRNA levels and PLD activity that was responsive to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	119-144	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	53-56
15063149-5	2004	To explore the mechanism of this effect, we employed flow cytometry to determine levels of p53, p21, bcl-2 and caspase proteins in the taxol-resistant cells, and found that the expression of the bcl-2 protein was markedly decreased and the expression of the caspase protein markedly increased after treatment with taxol in the presence of PMA.	Tetradecanoylphorbol Acetate	339-342	B cell leukemia/lymphoma 2	Mus musculus	195-200
15059889-7	2004	Abrogation of EGFR function in mouse epidermis using an EGFR kinase inhibitor or by overexpressing a dominant negative form of EGFR led to a reduction in Stat3 activation in response to TPA treatment.	Tetradecanoylphorbol Acetate	186-189	signal transducer and activator of transcription 3	Mus musculus	154-159
15059889-8	2004	Immunoprecipitation analyses using lysates from TPA-treated epidermis and skin papillomas showed enhanced interaction between the EGFR and Stat3.	Tetradecanoylphorbol Acetate	48-51	signal transducer and activator of transcription 3	Mus musculus	139-144
15059889-2	2004	Stat1, Stat3, and Stat5 were activated in mouse epidermis after treatment with different classes of tumor promoters, including 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and chrysarobin.	Tetradecanoylphorbol Acetate	127-163	signal transducer and activator of transcription 3	Mus musculus	7-12
15059889-9	2004	Finally, Stat3 deficiency in mouse epidermis significantly reduced the proliferative response after TPA treatment.	Tetradecanoylphorbol Acetate	100-103	signal transducer and activator of transcription 3	Mus musculus	9-14
15059889-3	2004	In addition, Stat1, Stat3, and Stat5 were constitutively activated in skin tumors generated by the two-stage carcinogenesis regimen using 7,12-dimethylbenz(a)anthracene as initiator and TPA as promoter.	Tetradecanoylphorbol Acetate	186-189	signal transducer and activator of transcription 3	Mus musculus	20-25
15034076-9	2004	Stimulation of T cells from nonpregnant females with PMA/ionomycin resulted in IkappaBalpha degradation, p65 translocation, and subsequent production of the Th1 cytokines IFN-gamma and IL-2.	Tetradecanoylphorbol Acetate	53-56	NFKB inhibitor alpha	Homo sapiens	79-91
14739659-2	2004	In this report, we show that growth-inhibitory concentrations of the dietary phytochemical resveratrol suppress EGFR-dependent Erk1/2 activation pathways stimulated by EGF and phorbol ester (12- O -tetradecanoyl phorbol 13-acetate, TPA) in human AI PrCa PC-3 cells in vitro.	Tetradecanoylphorbol Acetate	232-235	epidermal growth factor receptor	Homo sapiens	112-116
14739659-2	2004	In this report, we show that growth-inhibitory concentrations of the dietary phytochemical resveratrol suppress EGFR-dependent Erk1/2 activation pathways stimulated by EGF and phorbol ester (12- O -tetradecanoyl phorbol 13-acetate, TPA) in human AI PrCa PC-3 cells in vitro.	Tetradecanoylphorbol Acetate	232-235	mitogen-activated protein kinase 3	Homo sapiens	127-133
14739659-6	2004	The effects of resveratrol on TPA-induced PKC isozyme activation were defined by monitoring PKC isozyme translocation and autophosphorylation.	Tetradecanoylphorbol Acetate	30-33	protein kinase C alpha	Homo sapiens	42-45
14739659-6	2004	The effects of resveratrol on TPA-induced PKC isozyme activation were defined by monitoring PKC isozyme translocation and autophosphorylation.	Tetradecanoylphorbol Acetate	30-33	protein kinase C alpha	Homo sapiens	92-95
14739659-7	2004	Under conditions where resveratrol suppressed TPA-induced Erk1/2 activation, the phytochemical produced isozyme-selective interference with TPA-induced translocation of cytosolic PKCalpha to the membrane/cytoskeleton and selectively diminished the amount of autophosphorylated PKCalpha in the membrane/cytoskeleton of the TPA-treated cells.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 3	Homo sapiens	58-64
14739659-7	2004	Under conditions where resveratrol suppressed TPA-induced Erk1/2 activation, the phytochemical produced isozyme-selective interference with TPA-induced translocation of cytosolic PKCalpha to the membrane/cytoskeleton and selectively diminished the amount of autophosphorylated PKCalpha in the membrane/cytoskeleton of the TPA-treated cells.	Tetradecanoylphorbol Acetate	140-143	protein kinase C alpha	Homo sapiens	179-187
14739659-7	2004	Under conditions where resveratrol suppressed TPA-induced Erk1/2 activation, the phytochemical produced isozyme-selective interference with TPA-induced translocation of cytosolic PKCalpha to the membrane/cytoskeleton and selectively diminished the amount of autophosphorylated PKCalpha in the membrane/cytoskeleton of the TPA-treated cells.	Tetradecanoylphorbol Acetate	140-143	protein kinase C alpha	Homo sapiens	277-285
14739659-7	2004	Under conditions where resveratrol suppressed TPA-induced Erk1/2 activation, the phytochemical produced isozyme-selective interference with TPA-induced translocation of cytosolic PKCalpha to the membrane/cytoskeleton and selectively diminished the amount of autophosphorylated PKCalpha in the membrane/cytoskeleton of the TPA-treated cells.	Tetradecanoylphorbol Acetate	140-143	protein kinase C alpha	Homo sapiens	179-187
14739659-7	2004	Under conditions where resveratrol suppressed TPA-induced Erk1/2 activation, the phytochemical produced isozyme-selective interference with TPA-induced translocation of cytosolic PKCalpha to the membrane/cytoskeleton and selectively diminished the amount of autophosphorylated PKCalpha in the membrane/cytoskeleton of the TPA-treated cells.	Tetradecanoylphorbol Acetate	140-143	protein kinase C alpha	Homo sapiens	277-285
14709334-4	2004	In this study, we found that phorbol 12-myristate 13-acetate (PMA) induced JNK activation only in non-small cell lung cancer (NSCLC) cells, but not in small cell lung cancer (SCLC) cells, whereas ERK activation was detected in both cell types.	Tetradecanoylphorbol Acetate	29-60	mitogen-activated protein kinase 8	Homo sapiens	75-78
14709334-4	2004	In this study, we found that phorbol 12-myristate 13-acetate (PMA) induced JNK activation only in non-small cell lung cancer (NSCLC) cells, but not in small cell lung cancer (SCLC) cells, whereas ERK activation was detected in both cell types.	Tetradecanoylphorbol Acetate	62-65	mitogen-activated protein kinase 8	Homo sapiens	75-78
14709334-4	2004	In this study, we found that phorbol 12-myristate 13-acetate (PMA) induced JNK activation only in non-small cell lung cancer (NSCLC) cells, but not in small cell lung cancer (SCLC) cells, whereas ERK activation was detected in both cell types.	Tetradecanoylphorbol Acetate	62-65	mitogen-activated protein kinase 1	Homo sapiens	196-199
14709334-7	2004	Subcellular localization studies demonstrated that PMA induced translocation of PKC-alpha, -betaII, and -epsilon isoforms, but not PKC-delta, from the cytosol to the membrane.	Tetradecanoylphorbol Acetate	51-54	protein kinase C alpha	Homo sapiens	80-89
15039304-5	2004	We found that TPA-differentiated U937 cells usually showed resistance to LPS-induced apoptosis.	Tetradecanoylphorbol Acetate	14-17	toll-like receptor 4	Mus musculus	73-76
15037572-9	2004	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased nuclear AP1 factor level and binding to the hINV gene AP1-1 response element.	Tetradecanoylphorbol Acetate	15-51	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	171-174
15037572-9	2004	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased nuclear AP1 factor level and binding to the hINV gene AP1-1 response element.	Tetradecanoylphorbol Acetate	15-51	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	217-222
15037572-9	2004	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased nuclear AP1 factor level and binding to the hINV gene AP1-1 response element.	Tetradecanoylphorbol Acetate	53-56	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	171-174
15037572-9	2004	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased nuclear AP1 factor level and binding to the hINV gene AP1-1 response element.	Tetradecanoylphorbol Acetate	53-56	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	217-222
15034076-9	2004	Stimulation of T cells from nonpregnant females with PMA/ionomycin resulted in IkappaBalpha degradation, p65 translocation, and subsequent production of the Th1 cytokines IFN-gamma and IL-2.	Tetradecanoylphorbol Acetate	53-56	interferon gamma	Homo sapiens	171-180
15034076-9	2004	Stimulation of T cells from nonpregnant females with PMA/ionomycin resulted in IkappaBalpha degradation, p65 translocation, and subsequent production of the Th1 cytokines IFN-gamma and IL-2.	Tetradecanoylphorbol Acetate	53-56	interleukin 2	Homo sapiens	185-189
15047839-3	2004	The cellular CCAAT/enhancer-binding protein alpha (C/EBP alpha) is induced in TPA-treated PEL cells and contributes to transactivation of the promoters for all of these genes through both direct binding and cooperative interactions with RTA and RAP targeted to upstream C/EBP sites.	Tetradecanoylphorbol Acetate	78-81	CCAAT enhancer binding protein alpha	Homo sapiens	13-49
15047839-3	2004	The cellular CCAAT/enhancer-binding protein alpha (C/EBP alpha) is induced in TPA-treated PEL cells and contributes to transactivation of the promoters for all of these genes through both direct binding and cooperative interactions with RTA and RAP targeted to upstream C/EBP sites.	Tetradecanoylphorbol Acetate	78-81	CCAAT enhancer binding protein alpha	Homo sapiens	51-62
15144607-7	2004	(3) There was a positive correlation between the positive rate of nucleolar staining for NF-kappaB p65, the relative expression of VEGF protein and the percentage of G(2)/M phases of cell cycle in hypoxia PMA group (r = 0.587 - 0.710, P &lt; 0.05, respectively).	Tetradecanoylphorbol Acetate	205-208	nuclear factor kappa B subunit 1	Homo sapiens	89-98
15086456-5	2004	METHODS: The role of ROS in high glucose- and PKC-induced fibronectin expression was examined by quantification of cellular ROS after stimulation with high glucose and phorbol 12-myristate 13-acetate (PMA), by the effect of hydrogen peroxide (H(2)O(2)) and PMA on fibronectin expression, and finally by inhibition of ROS and PKC.	Tetradecanoylphorbol Acetate	168-199	proline rich transmembrane protein 2	Homo sapiens	46-49
15086456-5	2004	METHODS: The role of ROS in high glucose- and PKC-induced fibronectin expression was examined by quantification of cellular ROS after stimulation with high glucose and phorbol 12-myristate 13-acetate (PMA), by the effect of hydrogen peroxide (H(2)O(2)) and PMA on fibronectin expression, and finally by inhibition of ROS and PKC.	Tetradecanoylphorbol Acetate	168-199	fibronectin 1	Homo sapiens	58-69
15086456-5	2004	METHODS: The role of ROS in high glucose- and PKC-induced fibronectin expression was examined by quantification of cellular ROS after stimulation with high glucose and phorbol 12-myristate 13-acetate (PMA), by the effect of hydrogen peroxide (H(2)O(2)) and PMA on fibronectin expression, and finally by inhibition of ROS and PKC.	Tetradecanoylphorbol Acetate	201-204	proline rich transmembrane protein 2	Homo sapiens	46-49
15086456-5	2004	METHODS: The role of ROS in high glucose- and PKC-induced fibronectin expression was examined by quantification of cellular ROS after stimulation with high glucose and phorbol 12-myristate 13-acetate (PMA), by the effect of hydrogen peroxide (H(2)O(2)) and PMA on fibronectin expression, and finally by inhibition of ROS and PKC.	Tetradecanoylphorbol Acetate	201-204	fibronectin 1	Homo sapiens	58-69
14711820-8	2004	These data suggest that increased binding of Sp1, Sp2, and Sp3 to the TRE of the 8S-LOX promoter is a mechanism by which TPA induces 8S-LOX expression in keratinocytes.	Tetradecanoylphorbol Acetate	121-124	arachidonate 8-lipoxygenase	Mus musculus	81-87
14711820-8	2004	These data suggest that increased binding of Sp1, Sp2, and Sp3 to the TRE of the 8S-LOX promoter is a mechanism by which TPA induces 8S-LOX expression in keratinocytes.	Tetradecanoylphorbol Acetate	121-124	arachidonate 8-lipoxygenase	Mus musculus	133-139
15006553-5	2004	In the T cells stimulated with mitogenic lectin phytohemagglutinin (PHA) in conjunction with phorbol myristate acetate (PMA), 6-formylpterin suppressed the NF-kappaB-dependent transcription, the production of cytokines (IFN-gamma and IL-2) and the cell proliferation.	Tetradecanoylphorbol Acetate	93-118	nuclear factor kappa B subunit 1	Homo sapiens	156-165
15006553-5	2004	In the T cells stimulated with mitogenic lectin phytohemagglutinin (PHA) in conjunction with phorbol myristate acetate (PMA), 6-formylpterin suppressed the NF-kappaB-dependent transcription, the production of cytokines (IFN-gamma and IL-2) and the cell proliferation.	Tetradecanoylphorbol Acetate	93-118	interferon gamma	Homo sapiens	220-229
15006553-5	2004	In the T cells stimulated with mitogenic lectin phytohemagglutinin (PHA) in conjunction with phorbol myristate acetate (PMA), 6-formylpterin suppressed the NF-kappaB-dependent transcription, the production of cytokines (IFN-gamma and IL-2) and the cell proliferation.	Tetradecanoylphorbol Acetate	93-118	interleukin 2	Homo sapiens	234-238
15006553-5	2004	In the T cells stimulated with mitogenic lectin phytohemagglutinin (PHA) in conjunction with phorbol myristate acetate (PMA), 6-formylpterin suppressed the NF-kappaB-dependent transcription, the production of cytokines (IFN-gamma and IL-2) and the cell proliferation.	Tetradecanoylphorbol Acetate	120-123	nuclear factor kappa B subunit 1	Homo sapiens	156-165
15006553-5	2004	In the T cells stimulated with mitogenic lectin phytohemagglutinin (PHA) in conjunction with phorbol myristate acetate (PMA), 6-formylpterin suppressed the NF-kappaB-dependent transcription, the production of cytokines (IFN-gamma and IL-2) and the cell proliferation.	Tetradecanoylphorbol Acetate	120-123	interferon gamma	Homo sapiens	220-229
15081539-6	2004	Treating Pyst2-L transfected cells with known activators of the MAPK signaling cascade such as TPA or stimulating them by serum, it was demonstrated that the up regulation of phospho-Erk1/2, caused by these activators, was only partially suppressed by the over expression of the Pyst2-L phosphatase in these cells.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 3	Homo sapiens	64-68
15081539-6	2004	Treating Pyst2-L transfected cells with known activators of the MAPK signaling cascade such as TPA or stimulating them by serum, it was demonstrated that the up regulation of phospho-Erk1/2, caused by these activators, was only partially suppressed by the over expression of the Pyst2-L phosphatase in these cells.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 3	Homo sapiens	183-189
15081539-7	2004	These results together with our previous ones showing that the TPA-induced up regulation of Pyst2-L mRNA was only partially inhibited by the use of a specific Mek1/2 inhibitor, lead us to ask whether the Pyst2-L phosphatase has a monogamous relationship with the Erk2 protein.	Tetradecanoylphorbol Acetate	63-66	mitogen-activated protein kinase 1	Homo sapiens	263-267
14711812-5	2004	Like amyloid precursor protein, this zinc metalloprotease-mediated shedding of PrP(C) could be stimulated by phorbol myristate acetate and by copper ions.	Tetradecanoylphorbol Acetate	109-134	prion protein	Homo sapiens	79-85
14711820-1	2004	Murine 8S-lipoxygenase (8S-LOX) is a 12-O-tetradecanoylphorbol-13-acetate (TPA)-inducible lipoxygenase.	Tetradecanoylphorbol Acetate	37-73	arachidonate 8-lipoxygenase	Mus musculus	7-22
14711820-1	2004	Murine 8S-lipoxygenase (8S-LOX) is a 12-O-tetradecanoylphorbol-13-acetate (TPA)-inducible lipoxygenase.	Tetradecanoylphorbol Acetate	37-73	arachidonate 8-lipoxygenase	Mus musculus	24-30
14711820-1	2004	Murine 8S-lipoxygenase (8S-LOX) is a 12-O-tetradecanoylphorbol-13-acetate (TPA)-inducible lipoxygenase.	Tetradecanoylphorbol Acetate	75-78	arachidonate 8-lipoxygenase	Mus musculus	7-22
14711820-1	2004	Murine 8S-lipoxygenase (8S-LOX) is a 12-O-tetradecanoylphorbol-13-acetate (TPA)-inducible lipoxygenase.	Tetradecanoylphorbol Acetate	75-78	arachidonate 8-lipoxygenase	Mus musculus	24-30
14711820-3	2004	In this study, we found TPA-induced 8S-LOX mRNA expression is a result of increased transcription in SSIN primary keratinocytes and further investigated transcriptional regulation of 8S-LOX expression by cloning its promoter.	Tetradecanoylphorbol Acetate	24-27	arachidonate 8-lipoxygenase	Mus musculus	36-42
14711820-3	2004	In this study, we found TPA-induced 8S-LOX mRNA expression is a result of increased transcription in SSIN primary keratinocytes and further investigated transcriptional regulation of 8S-LOX expression by cloning its promoter.	Tetradecanoylphorbol Acetate	24-27	arachidonate 8-lipoxygenase	Mus musculus	183-189
14711820-6	2004	We then identified a Sp1 binding site located -77 to -68 from the ATG that is a TPA-responsive element (TRE) of the promoter and that Sp1, Sp2, and Sp3 proteins bind to the TRE.	Tetradecanoylphorbol Acetate	80-83	Sp2 transcription factor	Mus musculus	139-142
14711820-7	2004	We also found that the binding of these proteins to the TRE was significantly increased by TPA treatment and inhibition of the binding by mithramycin A decreased TPA-induced promoter activity as well as 8S-LOX mRNA expression.	Tetradecanoylphorbol Acetate	91-94	arachidonate 8-lipoxygenase	Mus musculus	203-209
14711820-8	2004	These data suggest that increased binding of Sp1, Sp2, and Sp3 to the TRE of the 8S-LOX promoter is a mechanism by which TPA induces 8S-LOX expression in keratinocytes.	Tetradecanoylphorbol Acetate	121-124	Sp2 transcription factor	Mus musculus	50-53
14630807-5	2004	In contrast, p300 was detectable in nucleus and its binding to a COX-2 promoter probe was enhanced by phorbol 12-myristate 13-acetate (PMA), interleukin-1 beta(IL-1 beta), or lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	102-133	prostaglandin-endoperoxide synthase 2	Homo sapiens	65-70
14630807-5	2004	In contrast, p300 was detectable in nucleus and its binding to a COX-2 promoter probe was enhanced by phorbol 12-myristate 13-acetate (PMA), interleukin-1 beta(IL-1 beta), or lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	135-138	prostaglandin-endoperoxide synthase 2	Homo sapiens	65-70
15006553-5	2004	In the T cells stimulated with mitogenic lectin phytohemagglutinin (PHA) in conjunction with phorbol myristate acetate (PMA), 6-formylpterin suppressed the NF-kappaB-dependent transcription, the production of cytokines (IFN-gamma and IL-2) and the cell proliferation.	Tetradecanoylphorbol Acetate	120-123	interleukin 2	Homo sapiens	234-238
15144607-7	2004	(3) There was a positive correlation between the positive rate of nucleolar staining for NF-kappaB p65, the relative expression of VEGF protein and the percentage of G(2)/M phases of cell cycle in hypoxia PMA group (r = 0.587 - 0.710, P &lt; 0.05, respectively).	Tetradecanoylphorbol Acetate	205-208	vascular endothelial growth factor A	Homo sapiens	131-135
14699137-3	2004	We report here that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate prevents DNA damage-induced up-regulation of p53 by down-regulating PKC delta.	Tetradecanoylphorbol Acetate	54-90	tumor protein p53	Homo sapiens	136-139
14661062-0	2004	Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction.	Tetradecanoylphorbol Acetate	21-46	mitogen-activated protein kinase 8	Homo sapiens	107-110
15020199-5	2004	In search for novel markers of skin tumor promotion, we found that TPA application to mouse skin resulted, as an early event, in an increased expression of phosphatidyinositol 3-kinase (PI3K), phosphorylation of Akt at threonine308 and activation of nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	67-70	thymoma viral proto-oncogene 1	Mus musculus	212-215
15020199-5	2004	In search for novel markers of skin tumor promotion, we found that TPA application to mouse skin resulted, as an early event, in an increased expression of phosphatidyinositol 3-kinase (PI3K), phosphorylation of Akt at threonine308 and activation of nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	67-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	250-272
15020199-5	2004	In search for novel markers of skin tumor promotion, we found that TPA application to mouse skin resulted, as an early event, in an increased expression of phosphatidyinositol 3-kinase (PI3K), phosphorylation of Akt at threonine308 and activation of nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	67-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	274-283
15020199-6	2004	Topical application of oleandrin before TPA application to mouse skin resulted in significant reduction in TPA-induced expression of PI3K and phosphorylation of Akt, and inhibition of NF-kappaB activation.	Tetradecanoylphorbol Acetate	107-110	thymoma viral proto-oncogene 1	Mus musculus	161-164
15020199-6	2004	Topical application of oleandrin before TPA application to mouse skin resulted in significant reduction in TPA-induced expression of PI3K and phosphorylation of Akt, and inhibition of NF-kappaB activation.	Tetradecanoylphorbol Acetate	107-110	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	184-193
15020199-8	2004	Employing Western blot analysis, we found that oleandrin application to mouse skin resulted in inhibition of TPA-induced activation of NF-kappaB, IKKalpha and phosphorylation and degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	109-112	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-144
15020199-8	2004	Employing Western blot analysis, we found that oleandrin application to mouse skin resulted in inhibition of TPA-induced activation of NF-kappaB, IKKalpha and phosphorylation and degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	109-112	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	194-206
14981539-3	2004	Here, we found that the PKC activators, phorbol 12-myristate 13-acetate (PMA) and bryostatin I, induced TRAF1 mRNA expression; pretreatment with actinomycin D blocked PMA-mediated TRAF1 expression suggesting induction at the transcriptional level.	Tetradecanoylphorbol Acetate	40-71	protein kinase C alpha	Homo sapiens	24-27
14661062-7	2004	Resveratrol inhibited PMA-mediated activation of c-Jun N-terminal kinase (JNK) and protein kinase C (PKC)-delta activation.	Tetradecanoylphorbol Acetate	22-25	mitogen-activated protein kinase 8	Homo sapiens	49-78
14981539-3	2004	Here, we found that the PKC activators, phorbol 12-myristate 13-acetate (PMA) and bryostatin I, induced TRAF1 mRNA expression; pretreatment with actinomycin D blocked PMA-mediated TRAF1 expression suggesting induction at the transcriptional level.	Tetradecanoylphorbol Acetate	40-71	TNF receptor associated factor 1	Homo sapiens	104-109
14981539-3	2004	Here, we found that the PKC activators, phorbol 12-myristate 13-acetate (PMA) and bryostatin I, induced TRAF1 mRNA expression; pretreatment with actinomycin D blocked PMA-mediated TRAF1 expression suggesting induction at the transcriptional level.	Tetradecanoylphorbol Acetate	40-71	TNF receptor associated factor 1	Homo sapiens	180-185
14981539-3	2004	Here, we found that the PKC activators, phorbol 12-myristate 13-acetate (PMA) and bryostatin I, induced TRAF1 mRNA expression; pretreatment with actinomycin D blocked PMA-mediated TRAF1 expression suggesting induction at the transcriptional level.	Tetradecanoylphorbol Acetate	73-76	protein kinase C alpha	Homo sapiens	24-27
14981539-3	2004	Here, we found that the PKC activators, phorbol 12-myristate 13-acetate (PMA) and bryostatin I, induced TRAF1 mRNA expression; pretreatment with actinomycin D blocked PMA-mediated TRAF1 expression suggesting induction at the transcriptional level.	Tetradecanoylphorbol Acetate	73-76	TNF receptor associated factor 1	Homo sapiens	104-109
14981539-3	2004	Here, we found that the PKC activators, phorbol 12-myristate 13-acetate (PMA) and bryostatin I, induced TRAF1 mRNA expression; pretreatment with actinomycin D blocked PMA-mediated TRAF1 expression suggesting induction at the transcriptional level.	Tetradecanoylphorbol Acetate	73-76	TNF receptor associated factor 1	Homo sapiens	180-185
14981539-6	2004	In addition, the MEK/ERK inhibitors, PD98059 and UO126, suppressed PMA-stimulated TRAF1 promoter activity indicating a role for ERK in TRAF1 induction.	Tetradecanoylphorbol Acetate	67-70	mitogen-activated protein kinase kinase 7	Homo sapiens	17-20
15104239-3	2004	In T- and B-lymphocytes (but not in monocytes) the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) (but not its inactive analogue 4alpha-phorbol-12,13-didecanoate) induced TH mRNA expression which was followed by an increase in the amount of intracellular CA.	Tetradecanoylphorbol Acetate	65-101	tyrosine hydroxylase	Homo sapiens	181-183
14981539-6	2004	In addition, the MEK/ERK inhibitors, PD98059 and UO126, suppressed PMA-stimulated TRAF1 promoter activity indicating a role for ERK in TRAF1 induction.	Tetradecanoylphorbol Acetate	67-70	mitogen-activated protein kinase 1	Homo sapiens	21-24
14981539-6	2004	In addition, the MEK/ERK inhibitors, PD98059 and UO126, suppressed PMA-stimulated TRAF1 promoter activity indicating a role for ERK in TRAF1 induction.	Tetradecanoylphorbol Acetate	67-70	TNF receptor associated factor 1	Homo sapiens	82-87
14981539-6	2004	In addition, the MEK/ERK inhibitors, PD98059 and UO126, suppressed PMA-stimulated TRAF1 promoter activity indicating a role for ERK in TRAF1 induction.	Tetradecanoylphorbol Acetate	67-70	mitogen-activated protein kinase 1	Homo sapiens	128-131
14981539-6	2004	In addition, the MEK/ERK inhibitors, PD98059 and UO126, suppressed PMA-stimulated TRAF1 promoter activity indicating a role for ERK in TRAF1 induction.	Tetradecanoylphorbol Acetate	67-70	TNF receptor associated factor 1	Homo sapiens	135-140
15104239-4	2004	Coincubation of human PBMC with dopamine (DA) (but not with norepinephrine or epinephrine) inhibited TPA-induced TH mRNA expression.	Tetradecanoylphorbol Acetate	101-104	tyrosine hydroxylase	Homo sapiens	113-115
15161022-7	2004	EGCG also abrogated the PMA-induced activation of extracellular-regulated protein kinase (Erk) and c-jun N-terminal kinase (JNK), which are upstream modulators of AP-1.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 1	Homo sapiens	50-88
15161022-7	2004	EGCG also abrogated the PMA-induced activation of extracellular-regulated protein kinase (Erk) and c-jun N-terminal kinase (JNK), which are upstream modulators of AP-1.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 1	Homo sapiens	90-93
15161022-7	2004	EGCG also abrogated the PMA-induced activation of extracellular-regulated protein kinase (Erk) and c-jun N-terminal kinase (JNK), which are upstream modulators of AP-1.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 8	Homo sapiens	99-122
15161022-7	2004	EGCG also abrogated the PMA-induced activation of extracellular-regulated protein kinase (Erk) and c-jun N-terminal kinase (JNK), which are upstream modulators of AP-1.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 8	Homo sapiens	124-127
15061693-4	2004	We are the first to measure GM3 synthase activity in human liver (194 +/- 60 pmol NeuAc/h per mg protein), which was about 10-fold lower than in phorbol myristate acetate-stimulated HL-60 cells (1353 +/- 573 pmol NeuAc/h per mg protein).	Tetradecanoylphorbol Acetate	145-170	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	28-40
15104247-4	2004	When combined with low concentrations of lipopolysaccharide, deactivated-lipopolysaccharide (dLPS) or phorbol-12-myristate-13-acetate that did not elicit TNF production alone, synergistic TNF production was obtained.	Tetradecanoylphorbol Acetate	102-133	tumor necrosis factor	Mus musculus	154-157
15104247-4	2004	When combined with low concentrations of lipopolysaccharide, deactivated-lipopolysaccharide (dLPS) or phorbol-12-myristate-13-acetate that did not elicit TNF production alone, synergistic TNF production was obtained.	Tetradecanoylphorbol Acetate	102-133	tumor necrosis factor	Mus musculus	188-191
15104239-3	2004	In T- and B-lymphocytes (but not in monocytes) the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) (but not its inactive analogue 4alpha-phorbol-12,13-didecanoate) induced TH mRNA expression which was followed by an increase in the amount of intracellular CA.	Tetradecanoylphorbol Acetate	103-106	tyrosine hydroxylase	Homo sapiens	181-183
15008985-7	2004	Our results show the elevated expression and release of tPA from normal human keratinocytes upon stimulation with antibodies to human BP180.	Tetradecanoylphorbol Acetate	56-59	collagen type XVII alpha 1 chain	Homo sapiens	134-139
14633657-2	2004	In the present work, we assessed the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on expression of iNOS and COX-2 in mouse skin.	Tetradecanoylphorbol Acetate	48-84	nitric oxide synthase 2, inducible	Mus musculus	108-112
14633657-2	2004	In the present work, we assessed the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on expression of iNOS and COX-2 in mouse skin.	Tetradecanoylphorbol Acetate	86-89	nitric oxide synthase 2, inducible	Mus musculus	108-112
14633657-3	2004	Topical application to the dorsal skin of female ICR mice of 10 nmol TPA led to maximal induction of iNOS and COX-2 protein expression at approximately 2 and 4 h, respectively.	Tetradecanoylphorbol Acetate	69-72	nitric oxide synthase 2, inducible	Mus musculus	101-105
14633657-5	2004	Pretreatment with a more specific iNOS inhibitor, N(G)-nitro-l-arginine-methyl ester, also suppressed TPA-induced COX-2 expression.	Tetradecanoylphorbol Acetate	102-105	nitric oxide synthase 2, inducible	Mus musculus	34-38
15008989-7	2004	In contrast, after 4 h of activation with PMA and ionomycin, the percentage of T cells producing high levels of IL-2 (M2) was greater in CF patients (P = 0.02).	Tetradecanoylphorbol Acetate	42-45	interleukin 2	Homo sapiens	112-116
14978237-2	2004	The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2.	Tetradecanoylphorbol Acetate	171-174	protein kinase C alpha	Homo sapiens	215-218
15041541-4	2004	PMA treatment caused an increase in extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK) activities.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	36-73
15041541-4	2004	PMA treatment caused an increase in extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK) activities.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	75-78
15041541-4	2004	PMA treatment caused an increase in extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK) activities.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	81-104
15041541-4	2004	PMA treatment caused an increase in extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK) activities.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	106-109
15041541-4	2004	PMA treatment caused an increase in extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK) activities.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	116-152
15041541-4	2004	PMA treatment caused an increase in extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK) activities.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	154-162
15005710-5	2004	Surprisingly, the c-Fos induced by the YXXQ-signal alone was localized to the cytoplasm, from which it translocated into the nucleus following TPA (12-O-tetradecanoyl-phorbol 13-acetate) treatment in a MEK/Erk-dependent manner.	Tetradecanoylphorbol Acetate	143-146	mitogen-activated protein kinase 1	Mus musculus	206-209
15005710-5	2004	Surprisingly, the c-Fos induced by the YXXQ-signal alone was localized to the cytoplasm, from which it translocated into the nucleus following TPA (12-O-tetradecanoyl-phorbol 13-acetate) treatment in a MEK/Erk-dependent manner.	Tetradecanoylphorbol Acetate	148-185	mitogen-activated protein kinase 1	Mus musculus	206-209
15037215-0	2004	Penta-O-galloyl-beta-D-glucose inhibits phorbol myristate acetate-induced interleukin-8 [correction of intereukin-8] gene expression in human monocytic U937 cells through its inactivation of nuclear factor-kappaB.	Tetradecanoylphorbol Acetate	40-65	C-X-C motif chemokine ligand 8	Homo sapiens	74-87
15037215-2	2004	PGG inhibited IL-8 production and gene expression in human monocytic U937 cells stimulated with phorbol myristate acetate (PMA), as measured by enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction analysis, respectively.	Tetradecanoylphorbol Acetate	96-121	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
15037215-2	2004	PGG inhibited IL-8 production and gene expression in human monocytic U937 cells stimulated with phorbol myristate acetate (PMA), as measured by enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction analysis, respectively.	Tetradecanoylphorbol Acetate	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
15037215-4	2004	Furthermore, PGG prevented PMA-mediated degradation of the NF-kappaB inhibitory protein I-kappaBalpha, as measured by Western blot analysis.	Tetradecanoylphorbol Acetate	27-30	NFKB inhibitor alpha	Homo sapiens	88-101
14994387-4	2004	IFN-gamma and IL-4 production by CD4+ T cells stimulated with phorbol myristate acetate (PMA) and calcium ionophore A23187 was measured by intracellular cytokine staining and flow cytometry.	Tetradecanoylphorbol Acetate	62-87	interferon gamma	Homo sapiens	0-9
14994387-4	2004	IFN-gamma and IL-4 production by CD4+ T cells stimulated with phorbol myristate acetate (PMA) and calcium ionophore A23187 was measured by intracellular cytokine staining and flow cytometry.	Tetradecanoylphorbol Acetate	62-87	interleukin 4	Homo sapiens	14-18
14994387-4	2004	IFN-gamma and IL-4 production by CD4+ T cells stimulated with phorbol myristate acetate (PMA) and calcium ionophore A23187 was measured by intracellular cytokine staining and flow cytometry.	Tetradecanoylphorbol Acetate	89-92	interferon gamma	Homo sapiens	0-9
14994387-4	2004	IFN-gamma and IL-4 production by CD4+ T cells stimulated with phorbol myristate acetate (PMA) and calcium ionophore A23187 was measured by intracellular cytokine staining and flow cytometry.	Tetradecanoylphorbol Acetate	89-92	interleukin 4	Homo sapiens	14-18
14978257-0	2004	Phorbol 12-myristate 13-acetate protects Jurkat cells from methylglyoxal-induced apoptosis by preventing c-Jun N-terminal kinase-mediated leakage of cytochrome c in an extracellular signal-regulated kinase-dependent manner.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 8	Homo sapiens	105-128
14978257-0	2004	Phorbol 12-myristate 13-acetate protects Jurkat cells from methylglyoxal-induced apoptosis by preventing c-Jun N-terminal kinase-mediated leakage of cytochrome c in an extracellular signal-regulated kinase-dependent manner.	Tetradecanoylphorbol Acetate	0-31	cytochrome c, somatic	Homo sapiens	149-161
14978237-3	2004	An association between c-Src and STAT1 was increased by IFN-gamma and TPA, indicating the direct phosphorylation of STAT1 by PKC-dependent c-Src activation.	Tetradecanoylphorbol Acetate	70-73	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	23-28
14978237-3	2004	An association between c-Src and STAT1 was increased by IFN-gamma and TPA, indicating the direct phosphorylation of STAT1 by PKC-dependent c-Src activation.	Tetradecanoylphorbol Acetate	70-73	protein kinase C alpha	Homo sapiens	125-128
14978257-5	2004	Taken together, these results suggest that PMA-induced ERK activation can protect Jurkat cells from methylglyoxal-induced apoptosis and that activated ERK exerts its antiapoptotic effects on mitochondria by inhibiting activated JNK-induced permeabilization of the outer mitochondrial membrane.	Tetradecanoylphorbol Acetate	43-46	mitogen-activated protein kinase 1	Homo sapiens	55-58
14978237-3	2004	An association between c-Src and STAT1 was increased by IFN-gamma and TPA, indicating the direct phosphorylation of STAT1 by PKC-dependent c-Src activation.	Tetradecanoylphorbol Acetate	70-73	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	139-144
14978257-5	2004	Taken together, these results suggest that PMA-induced ERK activation can protect Jurkat cells from methylglyoxal-induced apoptosis and that activated ERK exerts its antiapoptotic effects on mitochondria by inhibiting activated JNK-induced permeabilization of the outer mitochondrial membrane.	Tetradecanoylphorbol Acetate	43-46	mitogen-activated protein kinase 8	Homo sapiens	228-231
15030177-8	2004	Using [3H]choline chloride to prelabel MCs and measuring [3H]choline-containing metabolite release as PLD activity, PMA stimulated a significant increase of PLD activity under high glucose condition.	Tetradecanoylphorbol Acetate	116-119	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	102-105
14984736-4	2004	When either isoform of PLD was stably expressed in HEK-293 cells, we observed an increased PLD activity in a cell-free system and a 12-O-tetradecanoyl-13-phorbol acetate (TPA)-stimulated increase in PLD activity in intact cells.	Tetradecanoylphorbol Acetate	171-174	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	23-26
15030177-8	2004	Using [3H]choline chloride to prelabel MCs and measuring [3H]choline-containing metabolite release as PLD activity, PMA stimulated a significant increase of PLD activity under high glucose condition.	Tetradecanoylphorbol Acetate	116-119	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	157-160
14700523-8	2004	Induction of iNOS gene expression and NO production was examined in LPS/TPA-treated cells, but not obvious in LPS- or TPA-treated cells.	Tetradecanoylphorbol Acetate	72-75	nitric oxide synthase 2	Rattus norvegicus	13-17
14700523-11	2004	Wogonin and quercetin but not rutin, inhibitors of iNOS gene expression and NO production induced by LPS, showed the significant inhibition on LPS/TPA-induced transformation foci formation, accompanied by inhibiting iNOS gene expression, NO production and MMP9 activity.	Tetradecanoylphorbol Acetate	147-150	nitric oxide synthase 2	Rattus norvegicus	51-55
14700523-11	2004	Wogonin and quercetin but not rutin, inhibitors of iNOS gene expression and NO production induced by LPS, showed the significant inhibition on LPS/TPA-induced transformation foci formation, accompanied by inhibiting iNOS gene expression, NO production and MMP9 activity.	Tetradecanoylphorbol Acetate	147-150	nitric oxide synthase 2	Rattus norvegicus	216-220
14602083-7	2004	The requirement of PKC alpha in LPS-dependent TNFalpha induction was verified in PKC alpha-downregulated microglia which could be induced by phorbol-12-myristate-13-acetate pretreatment.	Tetradecanoylphorbol Acetate	141-172	protein kinase C alpha	Homo sapiens	19-28
14602083-7	2004	The requirement of PKC alpha in LPS-dependent TNFalpha induction was verified in PKC alpha-downregulated microglia which could be induced by phorbol-12-myristate-13-acetate pretreatment.	Tetradecanoylphorbol Acetate	141-172	tumor necrosis factor	Homo sapiens	46-54
14602083-7	2004	The requirement of PKC alpha in LPS-dependent TNFalpha induction was verified in PKC alpha-downregulated microglia which could be induced by phorbol-12-myristate-13-acetate pretreatment.	Tetradecanoylphorbol Acetate	141-172	protein kinase C alpha	Homo sapiens	81-90
14757314-4	2004	Tellimagrandin I also inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of CD61 protein, a megakaryocytic marker.	Tetradecanoylphorbol Acetate	32-68	integrin subunit beta 3	Homo sapiens	97-101
14757314-4	2004	Tellimagrandin I also inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of CD61 protein, a megakaryocytic marker.	Tetradecanoylphorbol Acetate	70-73	integrin subunit beta 3	Homo sapiens	97-101
15067739-1	2004	OBJECTIVE: To investigate the effect of mitogen Phorbol 12-myristate 13-Acetate (PMA) on CD3, CD4 and CD8 expression of human T-lymphocytes.	Tetradecanoylphorbol Acetate	48-79	CD4 molecule	Homo sapiens	94-97
15067739-1	2004	OBJECTIVE: To investigate the effect of mitogen Phorbol 12-myristate 13-Acetate (PMA) on CD3, CD4 and CD8 expression of human T-lymphocytes.	Tetradecanoylphorbol Acetate	81-84	CD4 molecule	Homo sapiens	94-97
14984736-5	2004	This system was then used to elucidate the effects of PLD activity on TPA-stimulated signaling pathways.	Tetradecanoylphorbol Acetate	70-73	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	54-57
14984736-7	2004	We found that TPA stimulated ERK phosphorylation regardless of the expression status of PLD.	Tetradecanoylphorbol Acetate	14-17	mitogen-activated protein kinase 1	Homo sapiens	29-32
14984736-9	2004	When HEK-293 cells expressed either PLD1 or PLD2, we observed elevated p38 phosphorylation in response to TPA stimulation.	Tetradecanoylphorbol Acetate	106-109	phospholipase D1	Homo sapiens	36-40
14984736-9	2004	When HEK-293 cells expressed either PLD1 or PLD2, we observed elevated p38 phosphorylation in response to TPA stimulation.	Tetradecanoylphorbol Acetate	106-109	mitogen-activated protein kinase 14	Homo sapiens	71-74
14729403-8	2004	Pre-incubation with the PKC activator, phorbol 12-myristate 13-acetate, resulted in an additive effect on membrane translocation of PKCalpha.	Tetradecanoylphorbol Acetate	39-70	protein kinase C alpha	Homo sapiens	24-27
14625290-4	2004	Stimulation of transfected cells with phorbol 12-myristate 13-acetate (PMA) induced metalloproteinase-mediated release of c-Kit ectodomain, which increased further upon TACE overexpression.	Tetradecanoylphorbol Acetate	38-69	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	122-127
14625290-4	2004	Stimulation of transfected cells with phorbol 12-myristate 13-acetate (PMA) induced metalloproteinase-mediated release of c-Kit ectodomain, which increased further upon TACE overexpression.	Tetradecanoylphorbol Acetate	71-74	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	122-127
14729403-8	2004	Pre-incubation with the PKC activator, phorbol 12-myristate 13-acetate, resulted in an additive effect on membrane translocation of PKCalpha.	Tetradecanoylphorbol Acetate	39-70	protein kinase C alpha	Homo sapiens	132-140
14981400-9	2004	Exposure to TPA for 5 and 30 minutes induced translocation of PKC alpha and PKC delta, respectively.	Tetradecanoylphorbol Acetate	12-15	protein kinase C alpha	Homo sapiens	62-71
14769215-4	2004	When K562 cells were treated with TPA 50 microg/L for 72 h to induce megakaryocytic differentiation, the presence of chebulinic acid 50 micromol/L slightly provoked the decrease of GPA protein expression induced by TPA.	Tetradecanoylphorbol Acetate	215-218	glycophorin A (MNS blood group)	Homo sapiens	181-184
14565945-3	2004	Secretion of phosphatidylcholine, surfactant protein (SP)-B and SP-C was stimulated by terbutaline, 5"-N-ethylcarboxyamidoadenosine (NECA), ATP, UTP, TPA, and ionomycin.	Tetradecanoylphorbol Acetate	150-153	sparse coat	Mus musculus	64-68
14610070-4	2004	In addition TPA decreased the intracellular GSH content, caused ERK activation, and potentiated the As(2)O(3)-provoked activation of p38 and JNK.	Tetradecanoylphorbol Acetate	12-15	mitogen-activated protein kinase 1	Homo sapiens	64-67
14630988-7	2004	In addition, the percentages of T cells secreting IFN-gamma after in vitro stimulation with phorbol myristate acetate and ionomycin was significantly higher in infected fetuses [10% (5-25)] than in healthy fetuses [0.8% (0.6-1.2)] with IFN-gamma being mostly secreted by CD8(+) T cells and to a lesser extend by CD4(+) T cells.	Tetradecanoylphorbol Acetate	92-117	interferon gamma	Homo sapiens	50-59
14630988-7	2004	In addition, the percentages of T cells secreting IFN-gamma after in vitro stimulation with phorbol myristate acetate and ionomycin was significantly higher in infected fetuses [10% (5-25)] than in healthy fetuses [0.8% (0.6-1.2)] with IFN-gamma being mostly secreted by CD8(+) T cells and to a lesser extend by CD4(+) T cells.	Tetradecanoylphorbol Acetate	92-117	interferon gamma	Homo sapiens	236-245
14630988-10	2004	Indeed, the number of T cells capable of secreting IFN-gamma is strikingly lower after in vitro stimulation with the CMV-specific antigen than after in vitro stimulation with phorbol myristate acetate/ionomycin that bypasses signaling through the T-cell receptor.	Tetradecanoylphorbol Acetate	175-200	interferon gamma	Homo sapiens	51-60
15061043-5	2004	RESULTS: The amount of staining with vWF (p = 0.04) and uPA (p = 0.02) showed statistically significant differences, PAI-1 (p = 0.09) and tPA (p = 0.50) showed no difference between leg ulcer and control groups.	Tetradecanoylphorbol Acetate	138-141	von Willebrand factor	Homo sapiens	37-40
14634065-3	2004	Although these are detectable even without stimulation, immunoglobulin (Ig)E receptor cross-linking is able to enhance only TNF-alpha production, but phorbol 12-myristate 13-acetate additionally promotes IL-1beta and IL-8.	Tetradecanoylphorbol Acetate	150-181	interleukin 1 beta	Homo sapiens	204-212
14634065-3	2004	Although these are detectable even without stimulation, immunoglobulin (Ig)E receptor cross-linking is able to enhance only TNF-alpha production, but phorbol 12-myristate 13-acetate additionally promotes IL-1beta and IL-8.	Tetradecanoylphorbol Acetate	150-181	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
14610070-6	2004	TPA also potentiated ERK activation and GSH depletion when added simultaneously to cadmium chloride (CdCl(2)) and doxorubicin.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	21-24
14610070-10	2004	It is concluded that TPA increases the apoptotic action of As(2)O(3), an effect mediated by ERK activation and GSH depletion.	Tetradecanoylphorbol Acetate	21-24	mitogen-activated protein kinase 1	Homo sapiens	92-95
14610070-4	2004	In addition TPA decreased the intracellular GSH content, caused ERK activation, and potentiated the As(2)O(3)-provoked activation of p38 and JNK.	Tetradecanoylphorbol Acetate	12-15	mitogen-activated protein kinase 14	Homo sapiens	133-136
14610070-4	2004	In addition TPA decreased the intracellular GSH content, caused ERK activation, and potentiated the As(2)O(3)-provoked activation of p38 and JNK.	Tetradecanoylphorbol Acetate	12-15	mitogen-activated protein kinase 8	Homo sapiens	141-144
14565953-10	2004	Expression of MUC20 mRNA in a human kidney cell line was up-regulated by tumor necrosis factor-alpha, phorbol 12-myristate 13-acetate, or lipopolysaccharide.	Tetradecanoylphorbol Acetate	102-133	mucin 20, cell surface associated	Homo sapiens	14-19
14556646-4	2004	In HEK-293 (human embryonic kidney 293) cells stably expressing recombinant IRS1 and in 3T3L1 adipocytes, rosiglitazone attenuated PMA-induced IRS1 S307/S612 phosphorylation and decreased insulin-stimulated Akt phosphorylation.	Tetradecanoylphorbol Acetate	131-134	insulin	Homo sapiens	188-195
14556646-4	2004	In HEK-293 (human embryonic kidney 293) cells stably expressing recombinant IRS1 and in 3T3L1 adipocytes, rosiglitazone attenuated PMA-induced IRS1 S307/S612 phosphorylation and decreased insulin-stimulated Akt phosphorylation.	Tetradecanoylphorbol Acetate	131-134	AKT serine/threonine kinase 1	Rattus norvegicus	207-210
14744771-3	2004	When nuclear export of the actin was induced by 12-O-tetradecanoylphorbol-13-acetate, DNA synthesis of the senescent cells increased significantly, accompanied with changes of morphologic and biochemical profiles, such as increased RB protein phosphorylation and decreased expressions of p21(WAF1), cytoplasmic p-extracellular signal-regulated kinase 1/2, and caveolins 1 and 2.	Tetradecanoylphorbol Acetate	48-84	cyclin dependent kinase inhibitor 1A	Homo sapiens	288-291
14744771-3	2004	When nuclear export of the actin was induced by 12-O-tetradecanoylphorbol-13-acetate, DNA synthesis of the senescent cells increased significantly, accompanied with changes of morphologic and biochemical profiles, such as increased RB protein phosphorylation and decreased expressions of p21(WAF1), cytoplasmic p-extracellular signal-regulated kinase 1/2, and caveolins 1 and 2.	Tetradecanoylphorbol Acetate	48-84	cyclin dependent kinase inhibitor 1A	Homo sapiens	292-296
14744771-3	2004	When nuclear export of the actin was induced by 12-O-tetradecanoylphorbol-13-acetate, DNA synthesis of the senescent cells increased significantly, accompanied with changes of morphologic and biochemical profiles, such as increased RB protein phosphorylation and decreased expressions of p21(WAF1), cytoplasmic p-extracellular signal-regulated kinase 1/2, and caveolins 1 and 2.	Tetradecanoylphorbol Acetate	48-84	caveolin 1	Homo sapiens	311-377
14698564-3	2004	Phorbol-12-myristate-13-acetate (PMA) potentiated (1 nM) TCDD-induced 7-ethoxyresorufin-O-deethylase (EROD) activity after 24h of treatment, and pre-treatment with (1 microM) of either a general PKC inhibitor (BisI) or PKCdelta-specific inhibitor (Rotterlin) abolished the potentiation indicating that activation of PKC enhances TCDD signal transduction.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, alpha	Mus musculus	195-198
14643968-0	2004	Glycoprotein isolated from Ulmus davidiana Nakai inhibits TPA-induced apoptosis through nuclear factor-kappa B in NIH/3T3 cells.	Tetradecanoylphorbol Acetate	58-61	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-110
14698564-3	2004	Phorbol-12-myristate-13-acetate (PMA) potentiated (1 nM) TCDD-induced 7-ethoxyresorufin-O-deethylase (EROD) activity after 24h of treatment, and pre-treatment with (1 microM) of either a general PKC inhibitor (BisI) or PKCdelta-specific inhibitor (Rotterlin) abolished the potentiation indicating that activation of PKC enhances TCDD signal transduction.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, alpha	Mus musculus	219-222
14698564-3	2004	Phorbol-12-myristate-13-acetate (PMA) potentiated (1 nM) TCDD-induced 7-ethoxyresorufin-O-deethylase (EROD) activity after 24h of treatment, and pre-treatment with (1 microM) of either a general PKC inhibitor (BisI) or PKCdelta-specific inhibitor (Rotterlin) abolished the potentiation indicating that activation of PKC enhances TCDD signal transduction.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, alpha	Mus musculus	195-198
14698564-3	2004	Phorbol-12-myristate-13-acetate (PMA) potentiated (1 nM) TCDD-induced 7-ethoxyresorufin-O-deethylase (EROD) activity after 24h of treatment, and pre-treatment with (1 microM) of either a general PKC inhibitor (BisI) or PKCdelta-specific inhibitor (Rotterlin) abolished the potentiation indicating that activation of PKC enhances TCDD signal transduction.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, alpha	Mus musculus	219-222
14732485-2	2004	In this study, changes in the activities and gene expressions of poly(ADP-ribose) glycohydrolases (PARG) in HL-60 cells treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or a PARG inhibitor, tannic acid, were investigated.	Tetradecanoylphorbol Acetate	133-170	poly(ADP-ribose) glycohydrolase	Homo sapiens	65-97
14583629-3	2004	Furthermore, we transfected human Jurkat T cells by a plasmid containing RasGRP and assessed the implication of endogenous DAGs on activation of MAP kinases ERK1/ERK2, induced by phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	179-210	mitogen-activated protein kinase 3	Homo sapiens	157-161
14583629-3	2004	Furthermore, we transfected human Jurkat T cells by a plasmid containing RasGRP and assessed the implication of endogenous DAGs on activation of MAP kinases ERK1/ERK2, induced by phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	179-210	mitogen-activated protein kinase 1	Homo sapiens	162-166
14570867-7	2004	Expression of ABCA1-GFP- and apoA-I-mediated lipid release were enhanced in parallel by phorbol 12-myristate 13-acetate (PMA) in 293/2c cells.	Tetradecanoylphorbol Acetate	88-119	apolipoprotein A1	Homo sapiens	29-35
14570867-7	2004	Expression of ABCA1-GFP- and apoA-I-mediated lipid release were enhanced in parallel by phorbol 12-myristate 13-acetate (PMA) in 293/2c cells.	Tetradecanoylphorbol Acetate	121-124	apolipoprotein A1	Homo sapiens	29-35
14732485-2	2004	In this study, changes in the activities and gene expressions of poly(ADP-ribose) glycohydrolases (PARG) in HL-60 cells treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or a PARG inhibitor, tannic acid, were investigated.	Tetradecanoylphorbol Acetate	133-170	poly(ADP-ribose) glycohydrolase	Homo sapiens	99-103
14732485-2	2004	In this study, changes in the activities and gene expressions of poly(ADP-ribose) glycohydrolases (PARG) in HL-60 cells treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or a PARG inhibitor, tannic acid, were investigated.	Tetradecanoylphorbol Acetate	172-175	poly(ADP-ribose) glycohydrolase	Homo sapiens	65-97
14732485-2	2004	In this study, changes in the activities and gene expressions of poly(ADP-ribose) glycohydrolases (PARG) in HL-60 cells treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or a PARG inhibitor, tannic acid, were investigated.	Tetradecanoylphorbol Acetate	172-175	poly(ADP-ribose) glycohydrolase	Homo sapiens	99-103
14732485-2	2004	In this study, changes in the activities and gene expressions of poly(ADP-ribose) glycohydrolases (PARG) in HL-60 cells treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or a PARG inhibitor, tannic acid, were investigated.	Tetradecanoylphorbol Acetate	172-175	poly(ADP-ribose) glycohydrolase	Homo sapiens	182-186
14732485-3	2004	Nuclear PARG activities of HL-60 cells treated with TPA were reduced to 30-40% of the activity in untreated cells at 24 h, while PARG activities in the cytoplasm remained unchanged.	Tetradecanoylphorbol Acetate	52-55	poly(ADP-ribose) glycohydrolase	Homo sapiens	8-12
14732485-3	2004	Nuclear PARG activities of HL-60 cells treated with TPA were reduced to 30-40% of the activity in untreated cells at 24 h, while PARG activities in the cytoplasm remained unchanged.	Tetradecanoylphorbol Acetate	52-55	poly(ADP-ribose) glycohydrolase	Homo sapiens	129-133
14732485-4	2004	The transient decrease in the nuclear PARG activity by TPA treatment was accompanied by differentiation as measured by the nitroblue tetrazolium (NBT) reducing activity and adhesion to the culture dishes.	Tetradecanoylphorbol Acetate	55-58	poly(ADP-ribose) glycohydrolase	Homo sapiens	38-42
14732485-8	2004	RT-PCR analysis revealed that TPA treatment leads to a reduction in the PARG gene expression prior to the phenotypic expression of macrophage-like cell differentiation, which was diminished by the presence of H7.	Tetradecanoylphorbol Acetate	30-33	poly(ADP-ribose) glycohydrolase	Homo sapiens	72-76
14631159-2	2004	Induced CD40L (CD154) expression following phorbol 12-myristate 13-acetate and ionomycin (P+I) stimulation was also examined on cultured CB CD4+ cells.	Tetradecanoylphorbol Acetate	43-74	CD40 ligand	Homo sapiens	8-13
14631159-2	2004	Induced CD40L (CD154) expression following phorbol 12-myristate 13-acetate and ionomycin (P+I) stimulation was also examined on cultured CB CD4+ cells.	Tetradecanoylphorbol Acetate	43-74	CD40 ligand	Homo sapiens	15-20
15630167-5	2004	To elucidate the molecular mechanism underlying COX-2 inhibition by resveratrol, we examined its effect on TPA-induced activation of mitogen-activated protein kinases (MAPK) and transcription factors which regulate COX-2 expression.	Tetradecanoylphorbol Acetate	107-110	mitogen-activated protein kinase 1	Mus musculus	168-172
14667941-4	2004	Using the superoxide dismutase (SOD)-inhibitable cytochrome c reduction assay, we report here that the beta-adrenergic agonist, adrenaline at physiologic concentrations (5-100 nM) inhibited formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated but not phorbol-myristate-acetate (PMA)-stimulated PMN superoxide anion production.	Tetradecanoylphorbol Acetate	254-279	cytochrome c, somatic	Homo sapiens	49-61
14667941-4	2004	Using the superoxide dismutase (SOD)-inhibitable cytochrome c reduction assay, we report here that the beta-adrenergic agonist, adrenaline at physiologic concentrations (5-100 nM) inhibited formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated but not phorbol-myristate-acetate (PMA)-stimulated PMN superoxide anion production.	Tetradecanoylphorbol Acetate	281-284	cytochrome c, somatic	Homo sapiens	49-61
15193278-3	2004	12-O-tetradecanoylphorbol-13-acetate (TPA) could induce cell death in PC-12 cells that overexpressed Bcl-2, implicating protein kinase C (PKC) in Bcl-2 protection.	Tetradecanoylphorbol Acetate	0-36	BCL2, apoptosis regulator	Rattus norvegicus	101-106
15010730-5	2004	RESULTS: A kinetic study in healthy controls showed that stimulation with phorbol 12-myristate 13-acetate and ionomycin significantly increased the frequencies of IL-10-producing CD3+, CD4+ and CD8+ cells.	Tetradecanoylphorbol Acetate	74-105	CD4 molecule	Homo sapiens	185-188
14757441-5	2004	Furthermore, when HL-60 myeloid leukemic cells were differentiated with phorbol ester (TPA), PBK/TOPK protein expression was strongly down-regulated by 24 h. Under these same conditions, phosphorylated c-Myc was rapidly down-regulated (by 4 h), while the levels of cyclin D1 and phosphorylated p38 were constant.	Tetradecanoylphorbol Acetate	87-90	PDZ binding kinase	Homo sapiens	93-96
14757441-5	2004	Furthermore, when HL-60 myeloid leukemic cells were differentiated with phorbol ester (TPA), PBK/TOPK protein expression was strongly down-regulated by 24 h. Under these same conditions, phosphorylated c-Myc was rapidly down-regulated (by 4 h), while the levels of cyclin D1 and phosphorylated p38 were constant.	Tetradecanoylphorbol Acetate	87-90	PDZ binding kinase	Homo sapiens	97-101
14757441-5	2004	Furthermore, when HL-60 myeloid leukemic cells were differentiated with phorbol ester (TPA), PBK/TOPK protein expression was strongly down-regulated by 24 h. Under these same conditions, phosphorylated c-Myc was rapidly down-regulated (by 4 h), while the levels of cyclin D1 and phosphorylated p38 were constant.	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase 14	Homo sapiens	294-297
15193278-3	2004	12-O-tetradecanoylphorbol-13-acetate (TPA) could induce cell death in PC-12 cells that overexpressed Bcl-2, implicating protein kinase C (PKC) in Bcl-2 protection.	Tetradecanoylphorbol Acetate	0-36	BCL2, apoptosis regulator	Rattus norvegicus	146-151
15193278-3	2004	12-O-tetradecanoylphorbol-13-acetate (TPA) could induce cell death in PC-12 cells that overexpressed Bcl-2, implicating protein kinase C (PKC) in Bcl-2 protection.	Tetradecanoylphorbol Acetate	38-41	BCL2, apoptosis regulator	Rattus norvegicus	101-106
15193278-3	2004	12-O-tetradecanoylphorbol-13-acetate (TPA) could induce cell death in PC-12 cells that overexpressed Bcl-2, implicating protein kinase C (PKC) in Bcl-2 protection.	Tetradecanoylphorbol Acetate	38-41	BCL2, apoptosis regulator	Rattus norvegicus	146-151
15581412-2	2004	To understand spatio-temporal regulation of vesicle recruitment by PKC, we studied the effects of a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), on the vesicle movements in living chromaffin cells by imaging with a fluorescence microscope-cooled CCD system.	Tetradecanoylphorbol Acetate	115-151	proline rich transmembrane protein 2	Homo sapiens	67-70
15581412-5	2004	TPA treatment, in addition, increased the number of visible chromaffin vesicles beneath the plasma membrane, suggesting that the potentiation of vesicle recruitment by PKC involves a substantial increase in the subplasmalemmal distribution of vesicles.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	168-171
14667834-1	2004	Activation of protein kinase C (PKC) by exposure of cultured human corneal epithelial cells to phorbol 12-myristate 13-acetate (PMA) resulted in an increase in paracellular permeability as evidenced by a decrease in transepithelial electrical resistance (TER).	Tetradecanoylphorbol Acetate	95-126	proline rich transmembrane protein 2	Homo sapiens	14-30
14667834-1	2004	Activation of protein kinase C (PKC) by exposure of cultured human corneal epithelial cells to phorbol 12-myristate 13-acetate (PMA) resulted in an increase in paracellular permeability as evidenced by a decrease in transepithelial electrical resistance (TER).	Tetradecanoylphorbol Acetate	95-126	proline rich transmembrane protein 2	Homo sapiens	32-35
14667834-1	2004	Activation of protein kinase C (PKC) by exposure of cultured human corneal epithelial cells to phorbol 12-myristate 13-acetate (PMA) resulted in an increase in paracellular permeability as evidenced by a decrease in transepithelial electrical resistance (TER).	Tetradecanoylphorbol Acetate	128-131	proline rich transmembrane protein 2	Homo sapiens	14-30
14667834-1	2004	Activation of protein kinase C (PKC) by exposure of cultured human corneal epithelial cells to phorbol 12-myristate 13-acetate (PMA) resulted in an increase in paracellular permeability as evidenced by a decrease in transepithelial electrical resistance (TER).	Tetradecanoylphorbol Acetate	128-131	proline rich transmembrane protein 2	Homo sapiens	32-35
14667834-2	2004	A change in the membrane distribution of the tight junction protein ZO-1 was also observed in the PMA-treated cells.	Tetradecanoylphorbol Acetate	98-101	tight junction protein 1	Homo sapiens	68-72
14667834-3	2004	In contrast, when the cells were treated with PMA in the presence of PD98059, a specific inhibitor of mitogen-activated protein kinase (MAPK) kinase, all barrier characteristics were preserved, suggesting that PKC induces tight junction disruption through the activation of MAPK.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 3	Homo sapiens	136-140
14667834-3	2004	In contrast, when the cells were treated with PMA in the presence of PD98059, a specific inhibitor of mitogen-activated protein kinase (MAPK) kinase, all barrier characteristics were preserved, suggesting that PKC induces tight junction disruption through the activation of MAPK.	Tetradecanoylphorbol Acetate	46-49	proline rich transmembrane protein 2	Homo sapiens	210-213
14667834-3	2004	In contrast, when the cells were treated with PMA in the presence of PD98059, a specific inhibitor of mitogen-activated protein kinase (MAPK) kinase, all barrier characteristics were preserved, suggesting that PKC induces tight junction disruption through the activation of MAPK.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 3	Homo sapiens	274-278
14713911-9	2004	Also, overexpression of pNHP(73-102), but not pVAX control, in phorbol myristate acetate-activated A549 cells resulted in a significant decrease in expression of a cotransfected nuclear factorkappaB (NFkappaB)-luciferase reporter.	Tetradecanoylphorbol Acetate	63-88	nuclear factor kappa B subunit 1	Homo sapiens	200-208
15046399-5	2004	The cells were stimulated with PMA or ionomycin, acting directly on PKC and calcineurin, respectively.	Tetradecanoylphorbol Acetate	31-34	proline rich transmembrane protein 2	Homo sapiens	68-71
15046399-8	2004	Only PMA and chelerythrine were able to change CD3 expression suggesting important involvement of PKC in the regulation of its expression.	Tetradecanoylphorbol Acetate	5-8	proline rich transmembrane protein 2	Homo sapiens	98-101
14584049-7	2004	Exposure of KCs to IFN-gamma plus TPA reduced total cellular p53 levels and reduced the transcriptional activity of p53.	Tetradecanoylphorbol Acetate	34-37	tumor protein p53	Homo sapiens	61-64
15153668-0	2004	A comparison of differences in the gene expression profiles of phorbol 12-myristate 13-acetate differentiated THP-1 cells and human monocyte-derived macrophage.	Tetradecanoylphorbol Acetate	63-94	GLI family zinc finger 2	Homo sapiens	110-115
14584049-7	2004	Exposure of KCs to IFN-gamma plus TPA reduced total cellular p53 levels and reduced the transcriptional activity of p53.	Tetradecanoylphorbol Acetate	34-37	tumor protein p53	Homo sapiens	116-119
14584049-9	2004	Pre-treatment of epidermal equivalents with IFN-gamma plus TPA also blocked UV-light induced increase in p53 levels, and reduced apoptosis.	Tetradecanoylphorbol Acetate	59-62	tumor protein p53	Homo sapiens	105-108
14691681-6	2004	This calcitonin-induced inhibition was mimicked by forskolin and dibutyryl-adenosine 3",5"-cyclic monophosphate (db-cAMP), which are protein kinase A (PKA) activators, but not by phorbol 12-myristate 13-acetate, a protein kinase C activator.	Tetradecanoylphorbol Acetate	179-210	calcitonin related polypeptide alpha	Homo sapiens	5-15
14717982-9	2004	We have also demonstrated that the ribavirin-treated CMK cells express PKC-alpha, -beta, -delta and -theta, and suggested that PKC-alpha and/or -beta appear to be responsible for PMA-induced activation of alpha IIb beta 3 in CMK cells.	Tetradecanoylphorbol Acetate	179-182	protein kinase C alpha	Homo sapiens	71-80
14673171-4	2004	We report here that ATF-3, JunB, and BRG-1 (the ATPase subunit of the 2-MDa human chromatin remodeling machine SWI/SNF) are recruited to the 3" boundary of nuc-1 following phorbol myristate acetate stimulation in Jurkat T cells.	Tetradecanoylphorbol Acetate	172-197	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-31
15067204-4	2004	Intracellular staining of interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) production in CD4+ lymphocytes after phorbol myristate acetate and ionomycin stimulation was performed at the same time points.	Tetradecanoylphorbol Acetate	117-142	interleukin 4	Homo sapiens	26-39
15067204-4	2004	Intracellular staining of interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) production in CD4+ lymphocytes after phorbol myristate acetate and ionomycin stimulation was performed at the same time points.	Tetradecanoylphorbol Acetate	117-142	interferon gamma	Homo sapiens	69-78
14630700-3	2004	PMA induced the phosphorylation of IKKbeta and the subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	0-3	NFKB inhibitor alpha	Homo sapiens	77-89
14630700-5	2004	PMA induced a 4.6-fold increase in NF-kappaB nuclear binding activity in control cells.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	35-44
15136882-5	2004	Treatment of NPVSM with 10 nM 4-beta phorbol myristate acetate (PMA), a PKC activator, induced translocation of PKCalpha, and PKCdelta from the soluble to the particulate fraction, while exposure to 10 nM endothelin-1 (ET-1), a potent vasoconstrictor and mitogenic substance, caused translocation of PKCdelta and PKCiota from the soluble to the particulate fraction.	Tetradecanoylphorbol Acetate	64-67	endothelin 1	Rattus norvegicus	205-217
15136882-5	2004	Treatment of NPVSM with 10 nM 4-beta phorbol myristate acetate (PMA), a PKC activator, induced translocation of PKCalpha, and PKCdelta from the soluble to the particulate fraction, while exposure to 10 nM endothelin-1 (ET-1), a potent vasoconstrictor and mitogenic substance, caused translocation of PKCdelta and PKCiota from the soluble to the particulate fraction.	Tetradecanoylphorbol Acetate	64-67	endothelin 1	Rattus norvegicus	219-223
15792026-5	2004	The intracellular expression of IL-4 and IFN-gamma in CD4+ or CD8+ cells after stimulation with ionomycin/PMA was estimated by flow cytometer (FACSCalibur, Becton Dickinson) and serum levels of both cytokines were assessed with ELISA (R &amp; D Systems) in all subjects.	Tetradecanoylphorbol Acetate	106-109	interleukin 4	Homo sapiens	32-36
15545011-5	2004	In contrast, phorbol ester (TPA, 100 nm), a PKC activator, increased cell death.	Tetradecanoylphorbol Acetate	28-31	proline rich transmembrane protein 2	Homo sapiens	44-47
15792026-5	2004	The intracellular expression of IL-4 and IFN-gamma in CD4+ or CD8+ cells after stimulation with ionomycin/PMA was estimated by flow cytometer (FACSCalibur, Becton Dickinson) and serum levels of both cytokines were assessed with ELISA (R &amp; D Systems) in all subjects.	Tetradecanoylphorbol Acetate	106-109	interferon gamma	Homo sapiens	41-50
15792026-5	2004	The intracellular expression of IL-4 and IFN-gamma in CD4+ or CD8+ cells after stimulation with ionomycin/PMA was estimated by flow cytometer (FACSCalibur, Becton Dickinson) and serum levels of both cytokines were assessed with ELISA (R &amp; D Systems) in all subjects.	Tetradecanoylphorbol Acetate	106-109	CD4 molecule	Homo sapiens	54-57
15327748-5	2004	Treatment with a potent PKC activator, phorbol-12-myristate-13-acetate (PMA), augmented GADD153 mRNA in Jurkat cells in the presence of hydrogen peroxide, although PMA alone induced GADD153 mRNA marginally.	Tetradecanoylphorbol Acetate	39-70	DNA damage inducible transcript 3	Homo sapiens	88-95
15327748-5	2004	Treatment with a potent PKC activator, phorbol-12-myristate-13-acetate (PMA), augmented GADD153 mRNA in Jurkat cells in the presence of hydrogen peroxide, although PMA alone induced GADD153 mRNA marginally.	Tetradecanoylphorbol Acetate	39-70	DNA damage inducible transcript 3	Homo sapiens	182-189
15327748-5	2004	Treatment with a potent PKC activator, phorbol-12-myristate-13-acetate (PMA), augmented GADD153 mRNA in Jurkat cells in the presence of hydrogen peroxide, although PMA alone induced GADD153 mRNA marginally.	Tetradecanoylphorbol Acetate	72-75	DNA damage inducible transcript 3	Homo sapiens	88-95
15327748-5	2004	Treatment with a potent PKC activator, phorbol-12-myristate-13-acetate (PMA), augmented GADD153 mRNA in Jurkat cells in the presence of hydrogen peroxide, although PMA alone induced GADD153 mRNA marginally.	Tetradecanoylphorbol Acetate	72-75	DNA damage inducible transcript 3	Homo sapiens	182-189
15081568-0	2004	The effect of TNF-alpha, PMA, and LPS on plasma and cell-associated IL-8 in human leukocytes.	Tetradecanoylphorbol Acetate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
14644416-1	2003	We studied the transcriptional regulation of human GM3 synthase (hST3Gal V) during monocytic differentiation of HL-60 cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	135-171	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	51-63
14527959-8	2003	Treatment with the proteasome inhibitor, MG132 or inhibitors of NF-kappa B (e.g. PDTC and gliotoxin), decreased PMA-induced up-regulation of cIAP-2.	Tetradecanoylphorbol Acetate	112-115	nuclear factor kappa B subunit 1	Homo sapiens	64-74
14522966-5	2003	Activation of ERK1/2 by pretreatment with phorbol 12-myristate 13-acetate or forced expression of ERK1/2 attenuated phytosphingosine-induced caspase-8 activation.	Tetradecanoylphorbol Acetate	42-73	mitogen-activated protein kinase 3	Homo sapiens	14-20
14506241-0	2003	DNase I hypersensitivity patterns of the serglycin proteoglycan gene in resting and phorbol 12-myristate 13-acetate-stimulated human erythroleukemia (HEL), CHRF 288-11, and HL-60 cells compared with neutrophils and human umbilical vein endothelial cells.	Tetradecanoylphorbol Acetate	84-115	serglycin	Homo sapiens	41-63
14532295-6	2003	TPA treatment further elevated this Ras activation in a PKC-independent manner and induced the translocation and down-regulation of RasGRP1.	Tetradecanoylphorbol Acetate	0-3	RAS guanyl releasing protein 1	Mus musculus	132-139
14635193-5	2003	MAPK activation is negated by an inhibitor to PKCalpha, but not PKCdelta inhibitors, in cells subjected to EMF exposure or TPA treatment.	Tetradecanoylphorbol Acetate	123-126	mitogen-activated protein kinase 1	Homo sapiens	0-4
14635193-5	2003	MAPK activation is negated by an inhibitor to PKCalpha, but not PKCdelta inhibitors, in cells subjected to EMF exposure or TPA treatment.	Tetradecanoylphorbol Acetate	123-126	protein kinase C alpha	Homo sapiens	46-54
14566822-6	2003	This increase of COX-2 expression by SNAP or PMA (potent inducer of both iNOS and COX-2) was blocked to various degrees by NO scavengers and NOS inhibitors (L-NAME and 1400W).	Tetradecanoylphorbol Acetate	45-48	prostaglandin-endoperoxide synthase 2	Homo sapiens	17-22
14566822-6	2003	This increase of COX-2 expression by SNAP or PMA (potent inducer of both iNOS and COX-2) was blocked to various degrees by NO scavengers and NOS inhibitors (L-NAME and 1400W).	Tetradecanoylphorbol Acetate	45-48	nitric oxide synthase 2	Homo sapiens	73-77
14566822-6	2003	This increase of COX-2 expression by SNAP or PMA (potent inducer of both iNOS and COX-2) was blocked to various degrees by NO scavengers and NOS inhibitors (L-NAME and 1400W).	Tetradecanoylphorbol Acetate	45-48	prostaglandin-endoperoxide synthase 2	Homo sapiens	82-87
14640580-3	2003	Western blot analysis showed that the methanolic extract of adlay seed inhibited basal and TPA-induced COX-2 expression in a dose-dependent fashion, whereas COX-1 expression was not affected.	Tetradecanoylphorbol Acetate	91-94	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
14640580-4	2003	By using a promoter activity assay, it was found that the methanolic extract inhibited basal and TPA-stimulated COX-2 expression at the transcription level.	Tetradecanoylphorbol Acetate	97-100	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	112-117
14644416-1	2003	We studied the transcriptional regulation of human GM3 synthase (hST3Gal V) during monocytic differentiation of HL-60 cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	135-171	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	65-75
14644416-1	2003	We studied the transcriptional regulation of human GM3 synthase (hST3Gal V) during monocytic differentiation of HL-60 cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	173-176	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	51-63
14644416-1	2003	We studied the transcriptional regulation of human GM3 synthase (hST3Gal V) during monocytic differentiation of HL-60 cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	173-176	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	65-75
14644416-3	2003	To elucidate the mechanism underlying the regulation of hST3Gal V gene expression during the differentiation of HL-60 cells induced by TPA, we characterized the promoter region of the hST3Gal V gene.	Tetradecanoylphorbol Acetate	135-138	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	56-65
14644416-3	2003	To elucidate the mechanism underlying the regulation of hST3Gal V gene expression during the differentiation of HL-60 cells induced by TPA, we characterized the promoter region of the hST3Gal V gene.	Tetradecanoylphorbol Acetate	135-138	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	184-193
14644416-5	2003	In addition, gel shift assays and site-directed mutagenesis indicated that the CREB binding site at -143 is crucial for the TPA-induced expression of the hST3Gal V in HL-60 cells.	Tetradecanoylphorbol Acetate	124-127	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	154-163
14623254-5	2003	By gel shift, competition, and supershift analyses we show here the specificity of the GATA-1 binding regulated by both anthracyclines and TPA.	Tetradecanoylphorbol Acetate	139-142	GATA binding protein 1	Homo sapiens	87-93
14672351-0	2003	12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation.	Tetradecanoylphorbol Acetate	0-36	nuclear factor kappa B subunit 1	Homo sapiens	100-109
14672351-0	2003	12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation.	Tetradecanoylphorbol Acetate	38-41	nuclear factor kappa B subunit 1	Homo sapiens	100-109
14672351-1	2003	UNLABELLED: The mechanism by which TPA-induced PKC activity modulates osteoclastogenesis is not clear.	Tetradecanoylphorbol Acetate	35-38	proline rich transmembrane protein 2	Homo sapiens	47-50
14672351-2	2003	Using a RAW(264.7) cell culture system and assays for NF-kappaB nuclear translocation, NF-kappaB reporter gene activity, and MAPK assays, we demonstrated that TPA inhibits osteoclastogenesis through the suppression of RANKL-induced NF-kappaB activation.	Tetradecanoylphorbol Acetate	159-162	nuclear factor kappa B subunit 1	Homo sapiens	54-63
14672351-2	2003	Using a RAW(264.7) cell culture system and assays for NF-kappaB nuclear translocation, NF-kappaB reporter gene activity, and MAPK assays, we demonstrated that TPA inhibits osteoclastogenesis through the suppression of RANKL-induced NF-kappaB activation.	Tetradecanoylphorbol Acetate	159-162	nuclear factor kappa B subunit 1	Homo sapiens	87-96
14672351-2	2003	Using a RAW(264.7) cell culture system and assays for NF-kappaB nuclear translocation, NF-kappaB reporter gene activity, and MAPK assays, we demonstrated that TPA inhibits osteoclastogenesis through the suppression of RANKL-induced NF-kappaB activation.	Tetradecanoylphorbol Acetate	159-162	mitogen-activated protein kinase 1	Homo sapiens	125-129
14672351-2	2003	Using a RAW(264.7) cell culture system and assays for NF-kappaB nuclear translocation, NF-kappaB reporter gene activity, and MAPK assays, we demonstrated that TPA inhibits osteoclastogenesis through the suppression of RANKL-induced NF-kappaB activation.	Tetradecanoylphorbol Acetate	159-162	nuclear factor kappa B subunit 1	Homo sapiens	87-96
14672351-5	2003	In this study, we examined the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA), a PKC activator, on osteoclastogenesis and studied its role in RANKL-induced signaling.	Tetradecanoylphorbol Acetate	42-78	proline rich transmembrane protein 2	Homo sapiens	88-91
14672351-5	2003	In this study, we examined the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA), a PKC activator, on osteoclastogenesis and studied its role in RANKL-induced signaling.	Tetradecanoylphorbol Acetate	80-83	proline rich transmembrane protein 2	Homo sapiens	88-91
14672351-10	2003	TPA alone had little effect on NF-kappaB activation in RAW(264.7) cells, but it suppresses the RANKL-induced NF-kappaB activation in a dose-dependent fashion.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	109-118
14672351-11	2003	Interestingly, the suppressive effect of TPA on RANKL-induced NF-kappaB activation was prevented by a conventional PKC inhibitor, Go6976.	Tetradecanoylphorbol Acetate	41-44	nuclear factor kappa B subunit 1	Homo sapiens	62-71
14672351-11	2003	Interestingly, the suppressive effect of TPA on RANKL-induced NF-kappaB activation was prevented by a conventional PKC inhibitor, Go6976.	Tetradecanoylphorbol Acetate	41-44	proline rich transmembrane protein 2	Homo sapiens	115-118
14672351-13	2003	In addition, TPA induced the activation of JNK in RAW(264.7) cells but had little effect on RANKL-induced activation of JNK.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 8	Homo sapiens	43-46
14672351-14	2003	TPA also inhibited RANKL-induced activation of ERK but had little effect on p38 activation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	47-50
14672351-15	2003	CONCLUSION: Given that NF-kappaB activation is obligatory for osteoclast differentiation, our studies imply that inhibition of osteoclastogenesis by TPA is, at least in part, caused by the suppression of RANKL-induced activation of NF-kappaB during an early stage of osteoclastogenesis.	Tetradecanoylphorbol Acetate	149-152	nuclear factor kappa B subunit 1	Homo sapiens	23-32
14672351-15	2003	CONCLUSION: Given that NF-kappaB activation is obligatory for osteoclast differentiation, our studies imply that inhibition of osteoclastogenesis by TPA is, at least in part, caused by the suppression of RANKL-induced activation of NF-kappaB during an early stage of osteoclastogenesis.	Tetradecanoylphorbol Acetate	149-152	nuclear factor kappa B subunit 1	Homo sapiens	232-241
12947046-5	2003	In addition, we demonstrated that the E2 repression could be antagonized by phorbol 12-myristate 13-acetate, which stimulated c-Jun phosphorylation on serine 63, a process that is a prerequisite for recruitment of the transcriptional coactivator cAMP response element binding protein (CREB)-binding protein (CBP).	Tetradecanoylphorbol Acetate	76-107	CREB binding protein	Homo sapiens	285-306
12947046-5	2003	In addition, we demonstrated that the E2 repression could be antagonized by phorbol 12-myristate 13-acetate, which stimulated c-Jun phosphorylation on serine 63, a process that is a prerequisite for recruitment of the transcriptional coactivator cAMP response element binding protein (CREB)-binding protein (CBP).	Tetradecanoylphorbol Acetate	76-107	CREB binding protein	Homo sapiens	308-311
14576072-6	2003	Several of these changes were also present in PMA-stimulated THP-1 macrophages in vitro.	Tetradecanoylphorbol Acetate	46-49	GLI family zinc finger 2	Homo sapiens	61-66
14714562-5	2003	Phorbol 12-myristate 13-acetate (PMA), an activator of PKC, inhibited proliferation, elevated intracellular calcium concentration, decreased the expression of K10, and increased the expressions of INV, FIL, and TG.	Tetradecanoylphorbol Acetate	0-31	protein kinase C alpha	Homo sapiens	55-58
14714562-5	2003	Phorbol 12-myristate 13-acetate (PMA), an activator of PKC, inhibited proliferation, elevated intracellular calcium concentration, decreased the expression of K10, and increased the expressions of INV, FIL, and TG.	Tetradecanoylphorbol Acetate	33-36	protein kinase C alpha	Homo sapiens	55-58
14645155-6	2003	Reduced CD154 promoter activity by neonatal cells persisted when proximal signaling events were bypassed using ionomycin and PMA, suggesting an additional and more distal mechanism for decreased transcription.	Tetradecanoylphorbol Acetate	125-128	CD40 ligand	Homo sapiens	8-13
14645155-7	2003	In contrast, CD154 mRNA stability was similar in neonatal and adult cells after either ionomycin and PMA stimulation or engagement of the alphabeta TCR-CD3 complex.	Tetradecanoylphorbol Acetate	101-104	CD40 ligand	Homo sapiens	13-18
14645681-3	2003	KCl-induced elevation of PEnk mRNA was distinct from activation of the PEnk gene by either cAMP or protein kinase C. Twenty-five micromolar forskolin- and 100 nM phorbol 12-myristate 13-acetate-induced elevations of PEnk mRNA were cycloheximide-sensitive and were not blocked by cyclosporin A or ascomycin.	Tetradecanoylphorbol Acetate	162-193	proenkephalin	Homo sapiens	25-29
14645681-3	2003	KCl-induced elevation of PEnk mRNA was distinct from activation of the PEnk gene by either cAMP or protein kinase C. Twenty-five micromolar forskolin- and 100 nM phorbol 12-myristate 13-acetate-induced elevations of PEnk mRNA were cycloheximide-sensitive and were not blocked by cyclosporin A or ascomycin.	Tetradecanoylphorbol Acetate	162-193	proenkephalin	Homo sapiens	71-75
14645681-3	2003	KCl-induced elevation of PEnk mRNA was distinct from activation of the PEnk gene by either cAMP or protein kinase C. Twenty-five micromolar forskolin- and 100 nM phorbol 12-myristate 13-acetate-induced elevations of PEnk mRNA were cycloheximide-sensitive and were not blocked by cyclosporin A or ascomycin.	Tetradecanoylphorbol Acetate	162-193	proenkephalin	Homo sapiens	71-75
14728848-14	2003	Meanwhile expression level of PKCalpha was decreased with the co-treatment of TPA or TAM and FSH comparing with treatment with FSH only.	Tetradecanoylphorbol Acetate	78-81	protein kinase C alpha	Homo sapiens	30-38
12960165-5	2003	Prx I gene induction by TPA was decreased by protein kinase C inhibitors and overexpressed dominant negative forms of Ras and MEKK1, but not Raf-1.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase kinase kinase 1	Rattus norvegicus	126-131
14647461-5	2003	In THP-1 cells differentiated to mature macrophage-like cells by PMA/TPA or ATRA, MLL-AF9 expression was downregulated.	Tetradecanoylphorbol Acetate	69-72	MLLT3 super elongation complex subunit	Homo sapiens	86-89
12952954-5	2003	An actinomycin D chase study and nuclear run-on assay revealed that the TPA-induced decrease in mt elongation factor Tu (EF-Tumt) mRNA mainly results from decreased mRNA stability.	Tetradecanoylphorbol Acetate	72-75	Tu translation elongation factor, mitochondrial	Homo sapiens	117-119
12952954-5	2003	An actinomycin D chase study and nuclear run-on assay revealed that the TPA-induced decrease in mt elongation factor Tu (EF-Tumt) mRNA mainly results from decreased mRNA stability.	Tetradecanoylphorbol Acetate	72-75	Tu translation elongation factor, mitochondrial	Homo sapiens	121-128
12920112-3	2003	Pre-treatment with 12-O-tetradecanoylphorbol-13-acetate (PMA) led to inhibition of TRAIL-induced apoptosis in HeLa cells, which was characterized by a reduction in phosphatidylserine (PS) externalization, decreased caspase-8 processing, and incomplete maturation and activation of caspase-3.	Tetradecanoylphorbol Acetate	19-55	TNF superfamily member 10	Homo sapiens	83-88
12920112-3	2003	Pre-treatment with 12-O-tetradecanoylphorbol-13-acetate (PMA) led to inhibition of TRAIL-induced apoptosis in HeLa cells, which was characterized by a reduction in phosphatidylserine (PS) externalization, decreased caspase-8 processing, and incomplete maturation and activation of caspase-3.	Tetradecanoylphorbol Acetate	19-55	caspase 3	Homo sapiens	281-290
12920112-3	2003	Pre-treatment with 12-O-tetradecanoylphorbol-13-acetate (PMA) led to inhibition of TRAIL-induced apoptosis in HeLa cells, which was characterized by a reduction in phosphatidylserine (PS) externalization, decreased caspase-8 processing, and incomplete maturation and activation of caspase-3.	Tetradecanoylphorbol Acetate	57-60	TNF superfamily member 10	Homo sapiens	83-88
12920112-3	2003	Pre-treatment with 12-O-tetradecanoylphorbol-13-acetate (PMA) led to inhibition of TRAIL-induced apoptosis in HeLa cells, which was characterized by a reduction in phosphatidylserine (PS) externalization, decreased caspase-8 processing, and incomplete maturation and activation of caspase-3.	Tetradecanoylphorbol Acetate	57-60	caspase 3	Homo sapiens	281-290
14596936-2	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced PLD1 activation was suppressed by the introduction of PKCdelta as well as its kinase-negative mutant in MeWo cells, which contain PKCalpha but lack PKCbeta.	Tetradecanoylphorbol Acetate	0-36	phospholipase D1	Homo sapiens	51-55
14596936-2	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced PLD1 activation was suppressed by the introduction of PKCdelta as well as its kinase-negative mutant in MeWo cells, which contain PKCalpha but lack PKCbeta.	Tetradecanoylphorbol Acetate	0-36	protein kinase C alpha	Homo sapiens	181-189
14596936-2	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced PLD1 activation was suppressed by the introduction of PKCdelta as well as its kinase-negative mutant in MeWo cells, which contain PKCalpha but lack PKCbeta.	Tetradecanoylphorbol Acetate	38-41	phospholipase D1	Homo sapiens	51-55
14596936-2	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced PLD1 activation was suppressed by the introduction of PKCdelta as well as its kinase-negative mutant in MeWo cells, which contain PKCalpha but lack PKCbeta.	Tetradecanoylphorbol Acetate	38-41	protein kinase C alpha	Homo sapiens	181-189
14596936-4	2003	In MeWo cells introduced by PKCalpha and PLD1, the association of these proteins was observed, which was enhanced by the TPA treatment.	Tetradecanoylphorbol Acetate	121-124	protein kinase C alpha	Homo sapiens	28-36
14596936-4	2003	In MeWo cells introduced by PKCalpha and PLD1, the association of these proteins was observed, which was enhanced by the TPA treatment.	Tetradecanoylphorbol Acetate	121-124	phospholipase D1	Homo sapiens	41-45
14596936-5	2003	In cells overexpressing PKCdelta in addition to PKCalpha and PLD1, TPA treatment increased the association of PKCdelta and PLD1, while it attenuated the association of PKCalpha and PLD1.	Tetradecanoylphorbol Acetate	67-70	protein kinase C alpha	Homo sapiens	48-56
14596936-5	2003	In cells overexpressing PKCdelta in addition to PKCalpha and PLD1, TPA treatment increased the association of PKCdelta and PLD1, while it attenuated the association of PKCalpha and PLD1.	Tetradecanoylphorbol Acetate	67-70	phospholipase D1	Homo sapiens	61-65
14627504-8	2003	The activation of AP-1 induced by PMA was also extensively inhibited by resveratrol at 0.1, 1, and 10 micromol/L.	Tetradecanoylphorbol Acetate	34-37	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-22
14596936-5	2003	In cells overexpressing PKCdelta in addition to PKCalpha and PLD1, TPA treatment increased the association of PKCdelta and PLD1, while it attenuated the association of PKCalpha and PLD1.	Tetradecanoylphorbol Acetate	67-70	phospholipase D1	Homo sapiens	123-127
14596936-5	2003	In cells overexpressing PKCdelta in addition to PKCalpha and PLD1, TPA treatment increased the association of PKCdelta and PLD1, while it attenuated the association of PKCalpha and PLD1.	Tetradecanoylphorbol Acetate	67-70	protein kinase C alpha	Homo sapiens	168-176
14596936-5	2003	In cells overexpressing PKCdelta in addition to PKCalpha and PLD1, TPA treatment increased the association of PKCdelta and PLD1, while it attenuated the association of PKCalpha and PLD1.	Tetradecanoylphorbol Acetate	67-70	phospholipase D1	Homo sapiens	123-127
14596936-6	2003	These results indicate that PKCdelta inhibits TPA-induced PLD1 activation mediated by PKCalpha through the association with PLD1.	Tetradecanoylphorbol Acetate	46-49	phospholipase D1	Homo sapiens	58-62
14596936-6	2003	These results indicate that PKCdelta inhibits TPA-induced PLD1 activation mediated by PKCalpha through the association with PLD1.	Tetradecanoylphorbol Acetate	46-49	protein kinase C alpha	Homo sapiens	86-94
12812920-5	2003	However, zinc deficiency increased the levels of TNF-alpha, IL-1 beta, and IL-8 cytokines and mRNAs in HL-60 cells after 6 h of PMA stimulation compared with zinc-sufficient cells.	Tetradecanoylphorbol Acetate	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
14596936-6	2003	These results indicate that PKCdelta inhibits TPA-induced PLD1 activation mediated by PKCalpha through the association with PLD1.	Tetradecanoylphorbol Acetate	46-49	phospholipase D1	Homo sapiens	124-128
14612503-0	2003	Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells.	Tetradecanoylphorbol Acetate	85-117	androgen receptor	Homo sapiens	55-72
14612503-3	2003	The use of the antiandrogen bicalutamide (Casodex) rescued LNCaP cells from 5-alpha-dihydrotestosterone (DHT)/TPA-induced apoptosis, suggesting that DHT/TPA-induced apoptosis is mediated by androgen/androgen receptor (AR).	Tetradecanoylphorbol Acetate	153-156	androgen receptor	Homo sapiens	199-216
14612503-4	2003	In addition, a caspase-3 inhibitor (Ac-DEVD-CHO) reduced the level of apoptosis, suggesting that DHT/TPA-mediated apoptosis occurs through a caspase-3-dependent pathway.	Tetradecanoylphorbol Acetate	101-104	caspase 3	Homo sapiens	15-24
14612503-4	2003	In addition, a caspase-3 inhibitor (Ac-DEVD-CHO) reduced the level of apoptosis, suggesting that DHT/TPA-mediated apoptosis occurs through a caspase-3-dependent pathway.	Tetradecanoylphorbol Acetate	101-104	caspase 3	Homo sapiens	141-150
14612503-6	2003	In addition, apoptosis mediated by combined DHT/TPA treatment was abrogated by overexpression of the NFkappaB subunit p65 in LNCaP-p65 cells, suggesting that NFkappaB may play an important role in regulating the effects of androgen/AR and TPA on apoptosis.	Tetradecanoylphorbol Acetate	48-51	nuclear factor kappa B subunit 1	Homo sapiens	101-109
14612503-6	2003	In addition, apoptosis mediated by combined DHT/TPA treatment was abrogated by overexpression of the NFkappaB subunit p65 in LNCaP-p65 cells, suggesting that NFkappaB may play an important role in regulating the effects of androgen/AR and TPA on apoptosis.	Tetradecanoylphorbol Acetate	48-51	nuclear factor kappa B subunit 1	Homo sapiens	158-166
14612503-6	2003	In addition, apoptosis mediated by combined DHT/TPA treatment was abrogated by overexpression of the NFkappaB subunit p65 in LNCaP-p65 cells, suggesting that NFkappaB may play an important role in regulating the effects of androgen/AR and TPA on apoptosis.	Tetradecanoylphorbol Acetate	239-242	nuclear factor kappa B subunit 1	Homo sapiens	101-109
14612503-6	2003	In addition, apoptosis mediated by combined DHT/TPA treatment was abrogated by overexpression of the NFkappaB subunit p65 in LNCaP-p65 cells, suggesting that NFkappaB may play an important role in regulating the effects of androgen/AR and TPA on apoptosis.	Tetradecanoylphorbol Acetate	239-242	nuclear factor kappa B subunit 1	Homo sapiens	158-166
14612503-7	2003	Furthermore, use of the c-Jun N-terminal kinase (JNK) inhibitor SB202190 showed that the combination of DHT/TPA increased JNK activation in LNCaP cells but not in LNCaP-p65 cells, demonstrating that NFkappaB may be able to suppress JNK activity.	Tetradecanoylphorbol Acetate	108-111	mitogen-activated protein kinase 8	Homo sapiens	49-52
14612503-7	2003	Furthermore, use of the c-Jun N-terminal kinase (JNK) inhibitor SB202190 showed that the combination of DHT/TPA increased JNK activation in LNCaP cells but not in LNCaP-p65 cells, demonstrating that NFkappaB may be able to suppress JNK activity.	Tetradecanoylphorbol Acetate	108-111	mitogen-activated protein kinase 8	Homo sapiens	122-125
14612503-7	2003	Furthermore, use of the c-Jun N-terminal kinase (JNK) inhibitor SB202190 showed that the combination of DHT/TPA increased JNK activation in LNCaP cells but not in LNCaP-p65 cells, demonstrating that NFkappaB may be able to suppress JNK activity.	Tetradecanoylphorbol Acetate	108-111	nuclear factor kappa B subunit 1	Homo sapiens	199-207
14612503-7	2003	Furthermore, use of the c-Jun N-terminal kinase (JNK) inhibitor SB202190 showed that the combination of DHT/TPA increased JNK activation in LNCaP cells but not in LNCaP-p65 cells, demonstrating that NFkappaB may be able to suppress JNK activity.	Tetradecanoylphorbol Acetate	108-111	mitogen-activated protein kinase 8	Homo sapiens	122-125
14612503-8	2003	These results indicate that androgen/AR facilitates TPA-induced apoptosis by interruption of the NFkappaB signaling pathway, leading to activation of JNK in LNCaP cells.	Tetradecanoylphorbol Acetate	52-55	nuclear factor kappa B subunit 1	Homo sapiens	97-105
14612503-8	2003	These results indicate that androgen/AR facilitates TPA-induced apoptosis by interruption of the NFkappaB signaling pathway, leading to activation of JNK in LNCaP cells.	Tetradecanoylphorbol Acetate	52-55	mitogen-activated protein kinase 8	Homo sapiens	150-153
14604548-6	2003	Results of additional experiments show that hAIM-29 activates intracellular calcium influx without Ig cross-linking and enhances phorbol myristate acetate-induced cell proliferation in a manner similar to other mouse anti-CD69 antibodies.	Tetradecanoylphorbol Acetate	129-154	chromosome 2 open reading frame 76	Homo sapiens	44-51
14682396-6	2003	Nevertheless, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) blocked the induction of apoptosis by lithium suggesting the involvement of the protein kinase C (PKC) signaling pathway.	Tetradecanoylphorbol Acetate	14-51	proline rich transmembrane protein 2	Homo sapiens	138-154
14682396-6	2003	Nevertheless, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) blocked the induction of apoptosis by lithium suggesting the involvement of the protein kinase C (PKC) signaling pathway.	Tetradecanoylphorbol Acetate	14-51	proline rich transmembrane protein 2	Homo sapiens	156-159
14682396-6	2003	Nevertheless, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) blocked the induction of apoptosis by lithium suggesting the involvement of the protein kinase C (PKC) signaling pathway.	Tetradecanoylphorbol Acetate	53-56	proline rich transmembrane protein 2	Homo sapiens	138-154
14682396-6	2003	Nevertheless, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) blocked the induction of apoptosis by lithium suggesting the involvement of the protein kinase C (PKC) signaling pathway.	Tetradecanoylphorbol Acetate	53-56	proline rich transmembrane protein 2	Homo sapiens	156-159
14573633-6	2003	Production of TNF-alpha was blunted upon depletion of protein kinase C by pretreatment of the cells with phorbol-12 myristate-13 acetate.	Tetradecanoylphorbol Acetate	105-136	tumor necrosis factor	Mus musculus	14-23
14724758-6	2003	Whereas the PKC activators phorbol-12-myristate-13-acetate (PMA) and sn-1,2-dioctanoyl glycerol (DOG) increased alpha-methyl glucose (AMG) uptake expressed by hSGLT1 alone as described earlier, PMA and DOG decreased AMG uptake mediated by hSGLT1 when hRS1 was co-expressed.	Tetradecanoylphorbol Acetate	27-58	solute carrier family 5 member 1	Homo sapiens	159-165
14608118-4	2003	In the present study, we found that pretreatment of the green tea extract enriched with catechin and epigallocatechin gallate (EGCG) by gavage inhibited COX-2 expression induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin.	Tetradecanoylphorbol Acetate	200-236	prostaglandin-endoperoxide synthase 2	Homo sapiens	153-158
14608118-4	2003	In the present study, we found that pretreatment of the green tea extract enriched with catechin and epigallocatechin gallate (EGCG) by gavage inhibited COX-2 expression induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin.	Tetradecanoylphorbol Acetate	238-241	prostaglandin-endoperoxide synthase 2	Homo sapiens	153-158
14608118-5	2003	Similarly, EGCG downregulated COX-2 in TPA-stimulated human mammary epithelial cells (MCF-10A) in culture.	Tetradecanoylphorbol Acetate	39-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	30-35
14724758-6	2003	Whereas the PKC activators phorbol-12-myristate-13-acetate (PMA) and sn-1,2-dioctanoyl glycerol (DOG) increased alpha-methyl glucose (AMG) uptake expressed by hSGLT1 alone as described earlier, PMA and DOG decreased AMG uptake mediated by hSGLT1 when hRS1 was co-expressed.	Tetradecanoylphorbol Acetate	27-58	solute carrier family 5 member 1	Homo sapiens	239-245
14724758-6	2003	Whereas the PKC activators phorbol-12-myristate-13-acetate (PMA) and sn-1,2-dioctanoyl glycerol (DOG) increased alpha-methyl glucose (AMG) uptake expressed by hSGLT1 alone as described earlier, PMA and DOG decreased AMG uptake mediated by hSGLT1 when hRS1 was co-expressed.	Tetradecanoylphorbol Acetate	60-63	solute carrier family 5 member 1	Homo sapiens	159-165
14724758-6	2003	Whereas the PKC activators phorbol-12-myristate-13-acetate (PMA) and sn-1,2-dioctanoyl glycerol (DOG) increased alpha-methyl glucose (AMG) uptake expressed by hSGLT1 alone as described earlier, PMA and DOG decreased AMG uptake mediated by hSGLT1 when hRS1 was co-expressed.	Tetradecanoylphorbol Acetate	60-63	solute carrier family 5 member 1	Homo sapiens	239-245
14573775-2	2003	In this study, TP mRNA and enzyme activity were found to be up-regulated upon the induction of differentiation of the human monocyte cell line THP-1 by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	152-183	GLI family zinc finger 2	Homo sapiens	143-148
14573775-2	2003	In this study, TP mRNA and enzyme activity were found to be up-regulated upon the induction of differentiation of the human monocyte cell line THP-1 by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	185-188	GLI family zinc finger 2	Homo sapiens	143-148
12947120-5	2003	These data suggest that TPA is able to induce LNCaP cell apoptosis via induction of TR3 resulting in the induction of E2F1.	Tetradecanoylphorbol Acetate	24-27	nuclear receptor subfamily 4 group A member 1	Homo sapiens	84-87
14529724-2	2003	Here, we show that TPA-induced depression of synaptic transmission between granule cells and Purkinje cells in culture is mediated through activation of the MEK1/2-ERK1/2 pathway.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase 3	Homo sapiens	164-170
14529724-3	2003	Phosphorylation of ERK1/2 induced by TPA and co-application of high potassium and glutamate was greatly attenuated by preincubating Purkinje cells with the MEK1/2 (MAPK ERK kinase 1/2) inhibitor PD98059.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 3	Homo sapiens	19-25
14529724-6	2003	These results suggest that ERK1/2 plays an essential role in TPA-induced depression via regulation of GluR2/3 declustering at the synapse.	Tetradecanoylphorbol Acetate	61-64	mitogen-activated protein kinase 3	Homo sapiens	27-33
12947120-3	2003	Here we found that 12-O-tetradecanoylphorbol-13-acetate (TPA) could induce cell apoptosis via induction of TR3 and E2F1 expression in LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	19-55	nuclear receptor subfamily 4 group A member 1	Homo sapiens	107-110
12947120-8	2003	Taken together, these data suggest that TPA is able to induce cell apoptosis via a TPA --&gt; TR3 --&gt; E2F1 --&gt; apoptosis pathway in LNCaP cells.	Tetradecanoylphorbol Acetate	40-43	nuclear receptor subfamily 4 group A member 1	Homo sapiens	94-97
12947120-3	2003	Here we found that 12-O-tetradecanoylphorbol-13-acetate (TPA) could induce cell apoptosis via induction of TR3 and E2F1 expression in LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	57-60	nuclear receptor subfamily 4 group A member 1	Homo sapiens	107-110
12947120-8	2003	Taken together, these data suggest that TPA is able to induce cell apoptosis via a TPA --&gt; TR3 --&gt; E2F1 --&gt; apoptosis pathway in LNCaP cells.	Tetradecanoylphorbol Acetate	83-86	nuclear receptor subfamily 4 group A member 1	Homo sapiens	94-97
14563411-6	2003	In addition, evidence is provided that TPA requires only one of the two C1 subdomains to trigger translocation to the plasma membrane.In summary, our data provide evidence that ceramide either directly or indirectly interacts with the Ca(2+)-dependent lipid binding C2 domain of PKCalpha and thereby induces translocation of the enzyme to the Golgi compartment.	Tetradecanoylphorbol Acetate	39-42	protein kinase C alpha	Homo sapiens	279-287
15085733-5	2003	The results indicate that the PKC activator phorbol 12-myristate 13-acetate (PMA) inhibits the meiotic resumption of cumulus-free mouse oocytes by a mechanism dependent not only on classical PKC activity but also on other PKC isoforms.	Tetradecanoylphorbol Acetate	44-75	protein kinase C, alpha	Mus musculus	30-33
15085733-5	2003	The results indicate that the PKC activator phorbol 12-myristate 13-acetate (PMA) inhibits the meiotic resumption of cumulus-free mouse oocytes by a mechanism dependent not only on classical PKC activity but also on other PKC isoforms.	Tetradecanoylphorbol Acetate	44-75	protein kinase C, alpha	Mus musculus	191-194
15085733-5	2003	The results indicate that the PKC activator phorbol 12-myristate 13-acetate (PMA) inhibits the meiotic resumption of cumulus-free mouse oocytes by a mechanism dependent not only on classical PKC activity but also on other PKC isoforms.	Tetradecanoylphorbol Acetate	44-75	protein kinase C, alpha	Mus musculus	191-194
15085733-5	2003	The results indicate that the PKC activator phorbol 12-myristate 13-acetate (PMA) inhibits the meiotic resumption of cumulus-free mouse oocytes by a mechanism dependent not only on classical PKC activity but also on other PKC isoforms.	Tetradecanoylphorbol Acetate	77-80	protein kinase C, alpha	Mus musculus	30-33
15085733-5	2003	The results indicate that the PKC activator phorbol 12-myristate 13-acetate (PMA) inhibits the meiotic resumption of cumulus-free mouse oocytes by a mechanism dependent not only on classical PKC activity but also on other PKC isoforms.	Tetradecanoylphorbol Acetate	77-80	protein kinase C, alpha	Mus musculus	191-194
15085733-5	2003	The results indicate that the PKC activator phorbol 12-myristate 13-acetate (PMA) inhibits the meiotic resumption of cumulus-free mouse oocytes by a mechanism dependent not only on classical PKC activity but also on other PKC isoforms.	Tetradecanoylphorbol Acetate	77-80	protein kinase C, alpha	Mus musculus	191-194
12972168-6	2003	TPA (12-O-tetradecanoylphorbol 13-acetate), a potent activator of PKC, induced GluR2/3 receptor declustering.	Tetradecanoylphorbol Acetate	0-3	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	79-84
12972168-6	2003	TPA (12-O-tetradecanoylphorbol 13-acetate), a potent activator of PKC, induced GluR2/3 receptor declustering.	Tetradecanoylphorbol Acetate	5-41	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	79-84
14583492-2	2003	The purpose of this study was to determine whether an angiogenic antagonist, SU5416, could inhibit endogenous and phorbol 12-myristate 13-acetate (PMA)-mediated induction of COX-2 expression.	Tetradecanoylphorbol Acetate	114-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
14583492-2	2003	The purpose of this study was to determine whether an angiogenic antagonist, SU5416, could inhibit endogenous and phorbol 12-myristate 13-acetate (PMA)-mediated induction of COX-2 expression.	Tetradecanoylphorbol Acetate	147-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-179
14583492-7	2003	An inhibitor of NADPH oxidase (diphenyleneiodonium chloride) blocked the PMA-mediated induction of COX-2 expression.	Tetradecanoylphorbol Acetate	73-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
13679066-3	2003	Phorbol 12-myristate 13-acetate (PMA), a non-specific activator of PKC, induced VEGF secretion by glioma cells, which was enhanced by calcium ionophore A23187, but completely blocked after prolonged treatment of cells with 1 microM PMA, by presumably depleting PKC.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	67-70
12890670-8	2003	Furthermore, activation of PKC alpha by phorbol 12-myristate 13-acetate inhibited the activity of wild-type DGK zeta, but not DGK zeta S/D, in human embryonic kidney 293 cells.	Tetradecanoylphorbol Acetate	40-71	protein kinase C alpha	Homo sapiens	27-36
12890670-8	2003	Furthermore, activation of PKC alpha by phorbol 12-myristate 13-acetate inhibited the activity of wild-type DGK zeta, but not DGK zeta S/D, in human embryonic kidney 293 cells.	Tetradecanoylphorbol Acetate	40-71	diacylglycerol kinase beta	Homo sapiens	108-111
14520467-5	2003	Activation of the ERK/MAPK was observed in parental K562 cells upon TPA treatment (5 nM, 5-30 min).	Tetradecanoylphorbol Acetate	68-71	mitogen-activated protein kinase 1	Homo sapiens	18-21
14520467-6	2003	As compared to K562/vector cells, less activation of ERK/MAPK was observed in K562/D2 cells, while ERK/MAPK was highly activated in K562/D3 cells upon TPA treatment.	Tetradecanoylphorbol Acetate	151-154	mitogen-activated protein kinase 1	Homo sapiens	99-102
12869563-7	2003	When the m80 ErbB-4 fragment is generated by cell treatment with heregulin or 12-O-tetradecanoylphorbol-13-acetate, the fragment associates with intact ErbB-2.	Tetradecanoylphorbol Acetate	78-114	erb-b2 receptor tyrosine kinase 2	Homo sapiens	152-158
14555991-5	2003	In K562 cells, Phorbol 12-myristate 13-acetate activates Erk1/2 and consequently increases Bim-EL phosphorylation and degradation by the proteasome, resulting in cell survival, while the Bcr-Abl inhibitor imatinib abrogates Bim-EL phosphorylation and degradation and induces caspase activation and apoptosis.	Tetradecanoylphorbol Acetate	15-46	mitogen-activated protein kinase 3	Homo sapiens	57-63
13679066-3	2003	Phorbol 12-myristate 13-acetate (PMA), a non-specific activator of PKC, induced VEGF secretion by glioma cells, which was enhanced by calcium ionophore A23187, but completely blocked after prolonged treatment of cells with 1 microM PMA, by presumably depleting PKC.	Tetradecanoylphorbol Acetate	0-31	vascular endothelial growth factor A	Homo sapiens	80-84
13679066-3	2003	Phorbol 12-myristate 13-acetate (PMA), a non-specific activator of PKC, induced VEGF secretion by glioma cells, which was enhanced by calcium ionophore A23187, but completely blocked after prolonged treatment of cells with 1 microM PMA, by presumably depleting PKC.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	261-264
13679066-3	2003	Phorbol 12-myristate 13-acetate (PMA), a non-specific activator of PKC, induced VEGF secretion by glioma cells, which was enhanced by calcium ionophore A23187, but completely blocked after prolonged treatment of cells with 1 microM PMA, by presumably depleting PKC.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	67-70
13679066-3	2003	Phorbol 12-myristate 13-acetate (PMA), a non-specific activator of PKC, induced VEGF secretion by glioma cells, which was enhanced by calcium ionophore A23187, but completely blocked after prolonged treatment of cells with 1 microM PMA, by presumably depleting PKC.	Tetradecanoylphorbol Acetate	33-36	vascular endothelial growth factor A	Homo sapiens	80-84
13679066-3	2003	Phorbol 12-myristate 13-acetate (PMA), a non-specific activator of PKC, induced VEGF secretion by glioma cells, which was enhanced by calcium ionophore A23187, but completely blocked after prolonged treatment of cells with 1 microM PMA, by presumably depleting PKC.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	261-264
13679066-3	2003	Phorbol 12-myristate 13-acetate (PMA), a non-specific activator of PKC, induced VEGF secretion by glioma cells, which was enhanced by calcium ionophore A23187, but completely blocked after prolonged treatment of cells with 1 microM PMA, by presumably depleting PKC.	Tetradecanoylphorbol Acetate	232-235	proline rich transmembrane protein 2	Homo sapiens	67-70
12801884-4	2003	Investigation of the effects of phorbol ester (12-o-tetradecanoylphorbol-13-acetate; TPA) and cAMP analogs in 32P-labeled pancreatic acini revealed that these agents acutely dephosphorylated CRHSP-24 by a Ca2+-independent mechanism.	Tetradecanoylphorbol Acetate	47-83	calcium regulated heat stable protein 1	Homo sapiens	191-199
12801884-5	2003	Indeed, cAMP- and TPA-mediated dephosphorylation of CRHSP-24 was fully inhibited by the PP1/PP2A inhibitor calyculin A, indicating that the protein is regulated by an additional phosphatase other than PP2B.	Tetradecanoylphorbol Acetate	18-21	calcium regulated heat stable protein 1	Homo sapiens	52-60
13679066-3	2003	Phorbol 12-myristate 13-acetate (PMA), a non-specific activator of PKC, induced VEGF secretion by glioma cells, which was enhanced by calcium ionophore A23187, but completely blocked after prolonged treatment of cells with 1 microM PMA, by presumably depleting PKC.	Tetradecanoylphorbol Acetate	232-235	vascular endothelial growth factor A	Homo sapiens	80-84
12801884-5	2003	Indeed, cAMP- and TPA-mediated dephosphorylation of CRHSP-24 was fully inhibited by the PP1/PP2A inhibitor calyculin A, indicating that the protein is regulated by an additional phosphatase other than PP2B.	Tetradecanoylphorbol Acetate	18-21	neuropeptide Y receptor Y4	Homo sapiens	88-91
12960243-4	2003	Immunoprecipitation experiments using plasma membranes of phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils revealed coimmunoprecipitation of PR3 with CD11b/CD18, indicating their location in the same complex.	Tetradecanoylphorbol Acetate	58-89	integrin subunit beta 2	Homo sapiens	168-172
14559850-0	2003	Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.	Tetradecanoylphorbol Acetate	37-73	tumor necrosis factor	Mus musculus	82-103
12928328-4	2003	By contrast, green fluorescent protein (GFP)-tagged tissue-type plasminogen activator (tPA-GFP) labelled submicron vesicular organelles.	Tetradecanoylphorbol Acetate	87-90	plasminogen activator, tissue type	Homo sapiens	52-85
12960243-4	2003	Immunoprecipitation experiments using plasma membranes of phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils revealed coimmunoprecipitation of PR3 with CD11b/CD18, indicating their location in the same complex.	Tetradecanoylphorbol Acetate	91-94	integrin subunit beta 2	Homo sapiens	168-172
14559850-3	2003	We now present that PKCepsilon transgenic mice elicit elevated serum tumor necrosis factor (TNF)alpha levels during skin tumor promotion by TPA, and this increase may be linked to the development of mSCC.	Tetradecanoylphorbol Acetate	140-143	tumor necrosis factor	Mus musculus	69-90
14559850-3	2003	We now present that PKCepsilon transgenic mice elicit elevated serum tumor necrosis factor (TNF)alpha levels during skin tumor promotion by TPA, and this increase may be linked to the development of mSCC.	Tetradecanoylphorbol Acetate	140-143	tumor necrosis factor	Mus musculus	92-101
14559850-4	2003	A single topical application of TPA (5 nmol) to the skin, as early as 2.5 h after treatment, resulted in a significant (P &lt; 0.01) increase (2-fold) in epidermal TNFalpha and more than a 6-fold increase in ectodomain shedding of TNFalpha into the serum of PKCepsilon transgenic mice relative to their wild-type littermates.	Tetradecanoylphorbol Acetate	32-35	tumor necrosis factor	Mus musculus	164-172
14559850-4	2003	A single topical application of TPA (5 nmol) to the skin, as early as 2.5 h after treatment, resulted in a significant (P &lt; 0.01) increase (2-fold) in epidermal TNFalpha and more than a 6-fold increase in ectodomain shedding of TNFalpha into the serum of PKCepsilon transgenic mice relative to their wild-type littermates.	Tetradecanoylphorbol Acetate	32-35	tumor necrosis factor	Mus musculus	231-239
14559850-5	2003	Furthermore, this TPA-stimulated TNFalpha shedding was proportional to the level of expression of PKCepsilon in the epidermis.	Tetradecanoylphorbol Acetate	18-21	tumor necrosis factor	Mus musculus	33-41
14559850-6	2003	Using the TNF-alpha converting enzyme (TACE) inhibitor, TAPI-1, TPA-stimulated TNFalpha shedding could be completely prevented in PKCepsilon transgenic mice and isolated keratinocytes.	Tetradecanoylphorbol Acetate	64-67	a disintegrin and metallopeptidase domain 17	Mus musculus	10-37
14559850-6	2003	Using the TNF-alpha converting enzyme (TACE) inhibitor, TAPI-1, TPA-stimulated TNFalpha shedding could be completely prevented in PKCepsilon transgenic mice and isolated keratinocytes.	Tetradecanoylphorbol Acetate	64-67	a disintegrin and metallopeptidase domain 17	Mus musculus	39-43
14559850-6	2003	Using the TNF-alpha converting enzyme (TACE) inhibitor, TAPI-1, TPA-stimulated TNFalpha shedding could be completely prevented in PKCepsilon transgenic mice and isolated keratinocytes.	Tetradecanoylphorbol Acetate	64-67	tumor necrosis factor	Mus musculus	79-87
14559850-7	2003	These results indicate that PKCepsilon signal transduction pathways to TPA-stimulated TNFalpha ectodomain shedding are mediated by TACE, a transmembrane metalloprotease.	Tetradecanoylphorbol Acetate	71-74	tumor necrosis factor	Mus musculus	86-94
14559850-7	2003	These results indicate that PKCepsilon signal transduction pathways to TPA-stimulated TNFalpha ectodomain shedding are mediated by TACE, a transmembrane metalloprotease.	Tetradecanoylphorbol Acetate	71-74	a disintegrin and metallopeptidase domain 17	Mus musculus	131-135
14559850-8	2003	Using the superoxide dismutase mimetic CuDIPs and the glutathione reductase mimetic ebselen, TPA-stimulated TNFalpha shedding from PKCepsilon transgenic mice could be completely attenuated, implying the role of reactive oxygen species.	Tetradecanoylphorbol Acetate	93-96	tumor necrosis factor	Mus musculus	108-116
14559850-11	2003	Taken together, these results indicate that: (a) PKCepsilon activation is an initial signal in TPA-induced shedding of TNFalpha from epidermal keratinocytes; (b) PKCepsilon-mediated signals to TACE are possibly mediated through reactive oxygen species; and (c) TPA-induced TNFalpha shedding may play a role in the development of mSCC in PKCepsilon transgenic mice.	Tetradecanoylphorbol Acetate	95-98	tumor necrosis factor	Mus musculus	119-127
14559850-11	2003	Taken together, these results indicate that: (a) PKCepsilon activation is an initial signal in TPA-induced shedding of TNFalpha from epidermal keratinocytes; (b) PKCepsilon-mediated signals to TACE are possibly mediated through reactive oxygen species; and (c) TPA-induced TNFalpha shedding may play a role in the development of mSCC in PKCepsilon transgenic mice.	Tetradecanoylphorbol Acetate	95-98	a disintegrin and metallopeptidase domain 17	Mus musculus	193-197
14559850-11	2003	Taken together, these results indicate that: (a) PKCepsilon activation is an initial signal in TPA-induced shedding of TNFalpha from epidermal keratinocytes; (b) PKCepsilon-mediated signals to TACE are possibly mediated through reactive oxygen species; and (c) TPA-induced TNFalpha shedding may play a role in the development of mSCC in PKCepsilon transgenic mice.	Tetradecanoylphorbol Acetate	95-98	tumor necrosis factor	Mus musculus	273-281
14559850-11	2003	Taken together, these results indicate that: (a) PKCepsilon activation is an initial signal in TPA-induced shedding of TNFalpha from epidermal keratinocytes; (b) PKCepsilon-mediated signals to TACE are possibly mediated through reactive oxygen species; and (c) TPA-induced TNFalpha shedding may play a role in the development of mSCC in PKCepsilon transgenic mice.	Tetradecanoylphorbol Acetate	261-264	tumor necrosis factor	Mus musculus	119-127
12950238-3	2003	In this study, the intracellular interleukin-4 and interferon-gamma production in CD4+ T-lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin was assessed via flow cytometry in order to determine the clinical significance of the Th1/Th2 ratio in 42 patients with ITP.	Tetradecanoylphorbol Acetate	114-145	interleukin 4	Homo sapiens	33-46
12950238-3	2003	In this study, the intracellular interleukin-4 and interferon-gamma production in CD4+ T-lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin was assessed via flow cytometry in order to determine the clinical significance of the Th1/Th2 ratio in 42 patients with ITP.	Tetradecanoylphorbol Acetate	114-145	interferon gamma	Homo sapiens	51-67
14500826-4	2003	Here we show that the increase of protein level following PKC activation by phorbol ester (TPA) treatment parallels that of hMSH2 mRNA.	Tetradecanoylphorbol Acetate	91-94	proline rich transmembrane protein 2	Homo sapiens	58-61
12829808-3	2003	In this report, we map the mGHR cleavage site by adenoviral overexpression of a membrane-anchored mGHR mutant lacking its cytoplasmic domain and purification and N-terminal sequencing of the phorbol 12-myristate 13-acetate-induced remnant protein.	Tetradecanoylphorbol Acetate	191-222	growth hormone receptor	Mus musculus	27-31
12829808-3	2003	In this report, we map the mGHR cleavage site by adenoviral overexpression of a membrane-anchored mGHR mutant lacking its cytoplasmic domain and purification and N-terminal sequencing of the phorbol 12-myristate 13-acetate-induced remnant protein.	Tetradecanoylphorbol Acetate	191-222	growth hormone receptor	Mus musculus	98-102
14500746-3	2003	Gastrin-releasing peptide receptor (GRPr) is phosphorylated by a kinase other than protein kinase C (PKC) after exposure to agonist and is also a substrate for PKC-dependent phosphorylation after treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	211-247	gastrin releasing peptide receptor	Homo sapiens	0-34
14500746-3	2003	Gastrin-releasing peptide receptor (GRPr) is phosphorylated by a kinase other than protein kinase C (PKC) after exposure to agonist and is also a substrate for PKC-dependent phosphorylation after treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	211-247	gastrin releasing peptide receptor	Homo sapiens	36-40
14500746-3	2003	Gastrin-releasing peptide receptor (GRPr) is phosphorylated by a kinase other than protein kinase C (PKC) after exposure to agonist and is also a substrate for PKC-dependent phosphorylation after treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	249-252	gastrin releasing peptide receptor	Homo sapiens	0-34
14500746-3	2003	Gastrin-releasing peptide receptor (GRPr) is phosphorylated by a kinase other than protein kinase C (PKC) after exposure to agonist and is also a substrate for PKC-dependent phosphorylation after treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	249-252	gastrin releasing peptide receptor	Homo sapiens	36-40
14500746-4	2003	Using GRPr mutants, we examined receptor domains required for agonist- and TPA-induced phosphorylation of GRPr and consequences of these phosphorylation events on GRPr signaling via Gq.	Tetradecanoylphorbol Acetate	75-78	gastrin releasing peptide receptor	Homo sapiens	106-110
14500746-4	2003	Using GRPr mutants, we examined receptor domains required for agonist- and TPA-induced phosphorylation of GRPr and consequences of these phosphorylation events on GRPr signaling via Gq.	Tetradecanoylphorbol Acetate	75-78	gastrin releasing peptide receptor	Homo sapiens	106-110
14500746-5	2003	Agonist- and TPA-stimulated GRPr phosphorylation in cells require an intact carboxyl terminal domain (CTD).	Tetradecanoylphorbol Acetate	13-16	gastrin releasing peptide receptor	Homo sapiens	28-32
14500746-5	2003	Agonist- and TPA-stimulated GRPr phosphorylation in cells require an intact carboxyl terminal domain (CTD).	Tetradecanoylphorbol Acetate	13-16	CTD	Homo sapiens	102-105
14500746-10	2003	TPA-mediated impairment of GRPr-Gq signaling in cells also requires an intact CTD.	Tetradecanoylphorbol Acetate	0-3	gastrin releasing peptide receptor	Homo sapiens	27-31
14500746-10	2003	TPA-mediated impairment of GRPr-Gq signaling in cells also requires an intact CTD.	Tetradecanoylphorbol Acetate	0-3	CTD	Homo sapiens	78-81
12826667-9	2003	12-O-Tetradecanoylphorbol-13-acetate stimulation, in contrast, causes translocation of PKCalpha to the plasma membrane, whereas the majority of PICK1 remains in a cytoplasmic punctate pattern.	Tetradecanoylphorbol Acetate	0-36	protein kinase C, alpha	Mus musculus	87-95
12867426-5	2003	We also show that two TSC2 mutants derived from TSC patients are defective in repressing phorbol 12-myristate 13-acetate-induced 4E-BP1 phosphorylation.	Tetradecanoylphorbol Acetate	89-120	TSC complex subunit 1	Homo sapiens	22-25
12867426-7	2003	Phosphorylation of tuberin by phorbol 12-myristate 13-acetate was reduced by treatment of cells with either bisindolylmaleimide I or UO126, inhibitors of PKC and MAPK/MEK (MAPK/ERK kinase), respectively, but not by wortmannin (an inhibitor of PI3K).	Tetradecanoylphorbol Acetate	30-61	mitogen-activated protein kinase kinase 7	Homo sapiens	167-170
12824193-7	2003	Stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) leads to the activation of ERK1/2, p38 MAPK, and JNK in LNCaP cells.	Tetradecanoylphorbol Acetate	22-53	proline rich transmembrane protein 2	Homo sapiens	15-18
12951045-5	2003	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), which directly stimulates protein kinase C (PKC) activity, completely prevented WISP-2 mRNA induction by E2, whereas it increased pS2 mRNA expression more dramatically than maximum stimulation by E2.	Tetradecanoylphorbol Acetate	15-51	trefoil factor 1	Homo sapiens	189-192
12951045-5	2003	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), which directly stimulates protein kinase C (PKC) activity, completely prevented WISP-2 mRNA induction by E2, whereas it increased pS2 mRNA expression more dramatically than maximum stimulation by E2.	Tetradecanoylphorbol Acetate	53-56	trefoil factor 1	Homo sapiens	189-192
12969638-1	2003	Bovine interleukin-21 (IL-21) cDNA was cloned and sequenced from bovine peripheral blood lymphocytes (PBLs) stimulated with 10 microg/ml concanavalin A (ConA), 10 microg/ml phytohemagglutinin (PHA), and 50 ng/ml phorbol 12-myristate 13-acetate (PMA) for 48 h. The open reading frame of the bovine IL-21 cDNA is 459 bp in length and encodes 152 amino acids.	Tetradecanoylphorbol Acetate	212-243	interleukin 21	Bos taurus	23-28
12969638-1	2003	Bovine interleukin-21 (IL-21) cDNA was cloned and sequenced from bovine peripheral blood lymphocytes (PBLs) stimulated with 10 microg/ml concanavalin A (ConA), 10 microg/ml phytohemagglutinin (PHA), and 50 ng/ml phorbol 12-myristate 13-acetate (PMA) for 48 h. The open reading frame of the bovine IL-21 cDNA is 459 bp in length and encodes 152 amino acids.	Tetradecanoylphorbol Acetate	245-248	interleukin 21	Bos taurus	23-28
12869568-7	2003	Additionally, MPO-mediated targeting of both monocyte and LDL plasmalogen pools was demonstrated in phorbol myristate acetate-stimulated human monocytes, resulting in the production of both 2-chlorohexadecanal and 2-chlorooctadecanal.	Tetradecanoylphorbol Acetate	100-125	myeloperoxidase	Homo sapiens	14-17
12824193-7	2003	Stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) leads to the activation of ERK1/2, p38 MAPK, and JNK in LNCaP cells.	Tetradecanoylphorbol Acetate	22-53	mitogen-activated protein kinase 3	Homo sapiens	87-93
12824193-7	2003	Stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) leads to the activation of ERK1/2, p38 MAPK, and JNK in LNCaP cells.	Tetradecanoylphorbol Acetate	22-53	mitogen-activated protein kinase 1	Homo sapiens	95-98
12824193-7	2003	Stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) leads to the activation of ERK1/2, p38 MAPK, and JNK in LNCaP cells.	Tetradecanoylphorbol Acetate	22-53	mitogen-activated protein kinase 3	Homo sapiens	99-103
12824193-7	2003	Stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) leads to the activation of ERK1/2, p38 MAPK, and JNK in LNCaP cells.	Tetradecanoylphorbol Acetate	22-53	mitogen-activated protein kinase 8	Homo sapiens	109-112
12824193-7	2003	Stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) leads to the activation of ERK1/2, p38 MAPK, and JNK in LNCaP cells.	Tetradecanoylphorbol Acetate	55-58	proline rich transmembrane protein 2	Homo sapiens	15-18
12824193-7	2003	Stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) leads to the activation of ERK1/2, p38 MAPK, and JNK in LNCaP cells.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 3	Homo sapiens	87-93
12824193-7	2003	Stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) leads to the activation of ERK1/2, p38 MAPK, and JNK in LNCaP cells.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 1	Homo sapiens	95-98
12824193-7	2003	Stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) leads to the activation of ERK1/2, p38 MAPK, and JNK in LNCaP cells.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 3	Homo sapiens	99-103
12824193-7	2003	Stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) leads to the activation of ERK1/2, p38 MAPK, and JNK in LNCaP cells.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 8	Homo sapiens	109-112
12738675-2	2003	Here, using a novel, highly phorbol myristate acetate (PMA)-responsive variant of the Jurkat T-cell line, we identify Ras and downstream mitogen-activated protein (MAP) kinase pathways as essential mediators of FucT-VII gene expression.	Tetradecanoylphorbol Acetate	28-53	fucosyltransferase 7	Homo sapiens	211-219
12887999-7	2003	Incubating dental follicle cells with phorbolmyristate acetate (PMA), a PKC activator, significantly up-regulated TNF-alpha gene expression in a dosage-dependent manner.	Tetradecanoylphorbol Acetate	38-62	tumor necrosis factor	Rattus norvegicus	114-123
12887999-7	2003	Incubating dental follicle cells with phorbolmyristate acetate (PMA), a PKC activator, significantly up-regulated TNF-alpha gene expression in a dosage-dependent manner.	Tetradecanoylphorbol Acetate	64-67	tumor necrosis factor	Rattus norvegicus	114-123
12738675-2	2003	Here, using a novel, highly phorbol myristate acetate (PMA)-responsive variant of the Jurkat T-cell line, we identify Ras and downstream mitogen-activated protein (MAP) kinase pathways as essential mediators of FucT-VII gene expression.	Tetradecanoylphorbol Acetate	55-58	fucosyltransferase 7	Homo sapiens	211-219
12963846-5	2003	In contrast to impairment in NaB- or PMA-induced NF-kappaB DNA binding, stable expression of the IkappaBalphaM did not modify DNA binding of SP1 or AP2 transcription factors.	Tetradecanoylphorbol Acetate	37-40	nuclear factor kappa B subunit 1	Homo sapiens	49-58
12844482-8	2003	Curcumin treatment attenuated TPA- stimulated NF-kappaB activation in mouse skin, which was associated with its blockade of degradation of the inhibitory protein IkappaBalpha and also of subsequent translocation of the p65 subunit to nucleus.	Tetradecanoylphorbol Acetate	30-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	46-55
12844482-8	2003	Curcumin treatment attenuated TPA- stimulated NF-kappaB activation in mouse skin, which was associated with its blockade of degradation of the inhibitory protein IkappaBalpha and also of subsequent translocation of the p65 subunit to nucleus.	Tetradecanoylphorbol Acetate	30-33	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	162-174
12844482-9	2003	TPA treatment resulted in rapid activation via phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and p38 mitogen-activated protein (MAP) kinases, which are upstream of NF-kappaB.	Tetradecanoylphorbol Acetate	0-3	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	184-193
12844482-11	2003	Furthermore, U0126 blocked the IkappaBalpha phosphorylation by TPA, thereby blocking the nuclear translocation of NF-kappaB.	Tetradecanoylphorbol Acetate	63-66	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	31-43
12844482-11	2003	Furthermore, U0126 blocked the IkappaBalpha phosphorylation by TPA, thereby blocking the nuclear translocation of NF-kappaB.	Tetradecanoylphorbol Acetate	63-66	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	114-123
12815050-6	2003	We also show that exogenous AEA inhibits the formation of cornified envelopes, a hallmark of keratinocyte differentiation, in HaCaT and NHEK cells treated with TPA plus calcium, through a CB1R-dependent reduction of transglutaminase and protein kinase C activity.	Tetradecanoylphorbol Acetate	160-163	cannabinoid receptor 1	Homo sapiens	188-192
12963846-6	2003	IkappaBalphaM cells also displayed impairment in NaB- and PMA-mediated induction of p21CIP1 and phosphorylation (inactivation) of p34cdc2, as well as diminished levels of pRb-bound E2F1.	Tetradecanoylphorbol Acetate	58-61	cyclin dependent kinase inhibitor 1A	Homo sapiens	84-91
12963846-7	2003	Finally, the NF-kappaB inhibitor CAPE antagonized NaB- and PMA-related NF-kappaB DNA binding as well as induction of p21CIP1.	Tetradecanoylphorbol Acetate	59-62	nuclear factor kappa B subunit 1	Homo sapiens	13-22
12963846-7	2003	Finally, the NF-kappaB inhibitor CAPE antagonized NaB- and PMA-related NF-kappaB DNA binding as well as induction of p21CIP1.	Tetradecanoylphorbol Acetate	59-62	nuclear factor kappa B subunit 1	Homo sapiens	71-80
12967635-8	2003	Phorbol myristate acetate (PMA; 200 nM), a direct activator of Ca(2+)-dependent and Ca(2+)-independent PKCs, activated PYK2 within 10 min, and PYK2 phosphorylation remained elevated after 30 min of stimulation.	Tetradecanoylphorbol Acetate	0-25	protein tyrosine kinase 2 beta	Rattus norvegicus	119-123
12898704-5	2003	Although PMA increased phosphorylation in all three major MAP kinase pathways (ERK, p38 MAP kinase, and JNK), only inhibition of the ERK pathway by the MEK/ERK inhibitor U0126 (0.1-10 microM) significantly reduced MMP-9 upregulation, even when treatment was delayed for 4 h after PMA exposure.	Tetradecanoylphorbol Acetate	9-12	Eph receptor B1	Rattus norvegicus	79-82
12938215-10	2003	CD21 shedding is induced by stimulation with PMA plus Ca(2+) ionophore, or by stimulation of the BCR with anti-IgM+anti-CD40.	Tetradecanoylphorbol Acetate	45-48	complement C3d receptor 2	Homo sapiens	0-4
12938167-1	2003	We have investigated the effects of sex steroids, estradiol (E2), and testosterone (T) on the synthesis of tumor necrosis factor alpha (TNF-alpha) and interleukin-10 (IL-10) in phorbol-myristate-acetate (PMA)-differentiated human monoblastic U937 cells.	Tetradecanoylphorbol Acetate	177-202	tumor necrosis factor	Homo sapiens	107-134
12938167-1	2003	We have investigated the effects of sex steroids, estradiol (E2), and testosterone (T) on the synthesis of tumor necrosis factor alpha (TNF-alpha) and interleukin-10 (IL-10) in phorbol-myristate-acetate (PMA)-differentiated human monoblastic U937 cells.	Tetradecanoylphorbol Acetate	177-202	tumor necrosis factor	Homo sapiens	136-145
12928424-5	2003	K5-PKCalpha transgenic mice exhibit severe intraepidermal neutrophilic inflammation and disruption of the epidermis and upper hair follicles when treated topically with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	169-205	protein kinase C, alpha	Mus musculus	3-11
12928424-5	2003	K5-PKCalpha transgenic mice exhibit severe intraepidermal neutrophilic inflammation and disruption of the epidermis and upper hair follicles when treated topically with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	207-210	protein kinase C, alpha	Mus musculus	3-11
12925217-6	2003	Two TPA-response elements on the nerve growth factor promoter were responsible for the activation by histamine.	Tetradecanoylphorbol Acetate	4-7	nerve growth factor	Homo sapiens	33-52
12967635-8	2003	Phorbol myristate acetate (PMA; 200 nM), a direct activator of Ca(2+)-dependent and Ca(2+)-independent PKCs, activated PYK2 within 10 min, and PYK2 phosphorylation remained elevated after 30 min of stimulation.	Tetradecanoylphorbol Acetate	27-30	protein tyrosine kinase 2 beta	Rattus norvegicus	143-147
12967635-8	2003	Phorbol myristate acetate (PMA; 200 nM), a direct activator of Ca(2+)-dependent and Ca(2+)-independent PKCs, activated PYK2 within 10 min, and PYK2 phosphorylation remained elevated after 30 min of stimulation.	Tetradecanoylphorbol Acetate	27-30	protein tyrosine kinase 2 beta	Rattus norvegicus	119-123
12929133-2	2003	In the present study, a protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) acts in concert with IFN-gamma to enhance nitric oxide (NO) production in murine microglial BV2 cells by synergistically increasing expression of inducible NO synthase (iNOS).	Tetradecanoylphorbol Acetate	57-88	interferon gamma	Mus musculus	116-125
12929133-2	2003	In the present study, a protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) acts in concert with IFN-gamma to enhance nitric oxide (NO) production in murine microglial BV2 cells by synergistically increasing expression of inducible NO synthase (iNOS).	Tetradecanoylphorbol Acetate	57-88	nitric oxide synthase 2, inducible	Mus musculus	241-262
12929133-2	2003	In the present study, a protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) acts in concert with IFN-gamma to enhance nitric oxide (NO) production in murine microglial BV2 cells by synergistically increasing expression of inducible NO synthase (iNOS).	Tetradecanoylphorbol Acetate	57-88	nitric oxide synthase 2, inducible	Mus musculus	264-268
12929133-2	2003	In the present study, a protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) acts in concert with IFN-gamma to enhance nitric oxide (NO) production in murine microglial BV2 cells by synergistically increasing expression of inducible NO synthase (iNOS).	Tetradecanoylphorbol Acetate	90-93	nitric oxide synthase 2, inducible	Mus musculus	241-262
12929133-2	2003	In the present study, a protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) acts in concert with IFN-gamma to enhance nitric oxide (NO) production in murine microglial BV2 cells by synergistically increasing expression of inducible NO synthase (iNOS).	Tetradecanoylphorbol Acetate	90-93	nitric oxide synthase 2, inducible	Mus musculus	264-268
12943994-1	2003	In this report we demonstrate that in human adrenocortical carcinoma NCI H295R cells, a model for adrenal glomerulosa cells, PLD was activated both by AngII and protein kinase C (PKC)-activating phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	195-226	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	125-128
12915572-6	2003	Furthermore, chromatin immunoprecipitation assay results showed that the endogenous C/EBPalpha, RTA, and RAP proteins all associate with RTA promoter sequences in tetradecanoyl phorbol acetate-induced primary effusion lymphoma (PEL) cells.	Tetradecanoylphorbol Acetate	163-192	CCAAT enhancer binding protein alpha	Homo sapiens	84-94
12950677-3	2003	Eosinophils were cultured for up to 72 h. Living cells were separated from the apoptotic cells and their release of eosinophil cationic protein (ECP) and eosinophil protein X (EPX) was measured in response to serum-opsonized sephadex particles and phorbol 12-myristate 12-acetate (PMA).	Tetradecanoylphorbol Acetate	281-284	eosinophil peroxidase	Homo sapiens	176-179
12865435-6	2003	Pretreatment of cells with a specific ROCK inhibitor, Y27632, not only abrogated MLC phosphorylation and membrane contraction, but also prevented PMA-induced activation of caspase-3 and subsequent cell death, indicating that ROCK-dependent myosin-mediated contraction elicits an upstream signal required for caspase-3 activation in PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	146-149	caspase 3	Homo sapiens	172-181
12865435-6	2003	Pretreatment of cells with a specific ROCK inhibitor, Y27632, not only abrogated MLC phosphorylation and membrane contraction, but also prevented PMA-induced activation of caspase-3 and subsequent cell death, indicating that ROCK-dependent myosin-mediated contraction elicits an upstream signal required for caspase-3 activation in PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	146-149	caspase 3	Homo sapiens	308-317
12865435-6	2003	Pretreatment of cells with a specific ROCK inhibitor, Y27632, not only abrogated MLC phosphorylation and membrane contraction, but also prevented PMA-induced activation of caspase-3 and subsequent cell death, indicating that ROCK-dependent myosin-mediated contraction elicits an upstream signal required for caspase-3 activation in PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	332-335	caspase 3	Homo sapiens	172-181
12730099-4	2003	Indeed, stimulation of Ramos B cells with the DAG analog phorbol ester myristate (PMA) results in the association of RasGRP3 with the membrane fraction.	Tetradecanoylphorbol Acetate	82-85	RAS guanyl releasing protein 3	Homo sapiens	117-124
15340565-11	2003	CONCLUSION: With the cooperating action of TPA, human oral tissue containing HPV 16 E6/E7 gene could cause malignant transformation in scid mice.	Tetradecanoylphorbol Acetate	43-46	protein E6*;transforming protein E6	Human papillomavirus type 16	84-89
12714508-2	2003	Transmembrane CX3CL1 is converted into its soluble form by defined proteolytic cleavage (shedding), which can be enhanced by stimulation with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	142-173	C-X3-C motif chemokine ligand 1	Homo sapiens	14-20
12714508-2	2003	Transmembrane CX3CL1 is converted into its soluble form by defined proteolytic cleavage (shedding), which can be enhanced by stimulation with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	175-178	C-X3-C motif chemokine ligand 1	Homo sapiens	14-20
12873514-2	2003	Detailed SAR studies led to the incorporation of specific functional groups in the tether that enhanced functional activity against thrombin and provided exquisite selectivity against trypsin and tPA.	Tetradecanoylphorbol Acetate	196-199	coagulation factor II, thrombin	Homo sapiens	132-140
12917633-0	2003	Role of protein kinase C and the Sp1-p53 complex in activation of p21(WAF-1) expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells.	Tetradecanoylphorbol Acetate	91-127	tumor protein p53	Homo sapiens	37-40
12917633-0	2003	Role of protein kinase C and the Sp1-p53 complex in activation of p21(WAF-1) expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells.	Tetradecanoylphorbol Acetate	91-127	cyclin dependent kinase inhibitor 1A	Homo sapiens	66-69
12917633-0	2003	Role of protein kinase C and the Sp1-p53 complex in activation of p21(WAF-1) expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells.	Tetradecanoylphorbol Acetate	91-127	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-75
12878187-2	2003	Here, we demonstrate that PKC activation via phorbol 12-myristate 13-acetate (PMA) treatment of MDA-MB-231 cells inhibits EGF-induced cell spreading, the initial event of motility and chemotaxis.	Tetradecanoylphorbol Acetate	45-76	protein kinase C alpha	Homo sapiens	26-29
12878187-2	2003	Here, we demonstrate that PKC activation via phorbol 12-myristate 13-acetate (PMA) treatment of MDA-MB-231 cells inhibits EGF-induced cell spreading, the initial event of motility and chemotaxis.	Tetradecanoylphorbol Acetate	78-81	protein kinase C alpha	Homo sapiens	26-29
12960735-6	2003	For the inhibition of basic fibroblast growth factor (bFGF)-, vascular endothelial growth factor (VEGF)- or beta-phorbol 12-myristate-13-acetate (PMA)-induced endothelial cell proliferation or endothelial cell adhesion to fibronectin, TMZ concentrations of at least 25 microM were necessary, indicating that bFGF-, VEGF- or protein kinase C-mediated pathways may not primarily be involved in the observed antiangiogenic effect.	Tetradecanoylphorbol Acetate	146-149	fibronectin 1	Homo sapiens	222-233
12902981-3	2003	Here, we report that NaB specifically represses the expression of the MUC2 gene, a differentiation marker of the secretory goblet cell lineage, in forskolin- and 12-O-tetradecanoylphorbol 13-acetate-induced HT29 cells, and Cl.16E cells, a clonal derivative of HT29 cells that spontaneously differentiates into goblet cells.	Tetradecanoylphorbol Acetate	162-198	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	70-74
12960759-3	2003	PMA treatment of these cells revealed significant delay of PKCalpha degradation in comparison with control HD 16Q cells.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Mus musculus	59-67
12960735-6	2003	For the inhibition of basic fibroblast growth factor (bFGF)-, vascular endothelial growth factor (VEGF)- or beta-phorbol 12-myristate-13-acetate (PMA)-induced endothelial cell proliferation or endothelial cell adhesion to fibronectin, TMZ concentrations of at least 25 microM were necessary, indicating that bFGF-, VEGF- or protein kinase C-mediated pathways may not primarily be involved in the observed antiangiogenic effect.	Tetradecanoylphorbol Acetate	146-149	fibroblast growth factor 2	Homo sapiens	308-312
12960735-6	2003	For the inhibition of basic fibroblast growth factor (bFGF)-, vascular endothelial growth factor (VEGF)- or beta-phorbol 12-myristate-13-acetate (PMA)-induced endothelial cell proliferation or endothelial cell adhesion to fibronectin, TMZ concentrations of at least 25 microM were necessary, indicating that bFGF-, VEGF- or protein kinase C-mediated pathways may not primarily be involved in the observed antiangiogenic effect.	Tetradecanoylphorbol Acetate	146-149	vascular endothelial growth factor A	Homo sapiens	315-320
12811831-5	2003	The Ang II-induced proliferation of breast cancer cells was reduced by (a) Go6976, an inhibitor of conventional PKC-alpha and -beta1, (b) AG1478, an inhibitor of the tyrosine kinase of the EGF receptor (EGFR), and (c) downregulation of 1,2-diacylglycerol-sensitive PKCs achieved by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	315-318	angiotensinogen	Homo sapiens	4-10
15090250-3	2003	Treatment of anergic Jurkat cells with the combination of the phorbol ester, PMA, and ionomycin restored IL-2 production in cells rendered anergic by both mechanisms.	Tetradecanoylphorbol Acetate	77-80	interleukin 2	Homo sapiens	105-109
12882914-6	2003	EDG-1 mRNA but not EDG-3 mRNA was rapidly induced relative to 18S rRNA after stimulation of isolated islets with phorbol 12-myristate 13-acetate (PMA) or cholecystokinin-8S for 2 h. The protein kinase C inhibitor GF 109203X blocked the EDG-1 induction by PMA.	Tetradecanoylphorbol Acetate	113-144	sphingosine-1-phosphate receptor 1	Rattus norvegicus	0-5
12882914-6	2003	EDG-1 mRNA but not EDG-3 mRNA was rapidly induced relative to 18S rRNA after stimulation of isolated islets with phorbol 12-myristate 13-acetate (PMA) or cholecystokinin-8S for 2 h. The protein kinase C inhibitor GF 109203X blocked the EDG-1 induction by PMA.	Tetradecanoylphorbol Acetate	146-149	sphingosine-1-phosphate receptor 1	Rattus norvegicus	0-5
12882914-6	2003	EDG-1 mRNA but not EDG-3 mRNA was rapidly induced relative to 18S rRNA after stimulation of isolated islets with phorbol 12-myristate 13-acetate (PMA) or cholecystokinin-8S for 2 h. The protein kinase C inhibitor GF 109203X blocked the EDG-1 induction by PMA.	Tetradecanoylphorbol Acetate	255-258	sphingosine-1-phosphate receptor 1	Rattus norvegicus	0-5
12881422-3	2003	However, the phorbol ester (TPA) and EGF-induced phosphorylation of Ser63 and Ser73 is mediated by ERK1/ERK2, as well as JNK1/JNK2, in fibroblasts from wild-type mice and by ERK1/ERK2 alone in fibroblasts from JNK-deficient mice.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 1	Mus musculus	104-108
12881422-3	2003	However, the phorbol ester (TPA) and EGF-induced phosphorylation of Ser63 and Ser73 is mediated by ERK1/ERK2, as well as JNK1/JNK2, in fibroblasts from wild-type mice and by ERK1/ERK2 alone in fibroblasts from JNK-deficient mice.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 9	Mus musculus	126-130
12881422-3	2003	However, the phorbol ester (TPA) and EGF-induced phosphorylation of Ser63 and Ser73 is mediated by ERK1/ERK2, as well as JNK1/JNK2, in fibroblasts from wild-type mice and by ERK1/ERK2 alone in fibroblasts from JNK-deficient mice.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 1	Mus musculus	179-183
19180800-4	2003	Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively.	Tetradecanoylphorbol Acetate	39-70	tumor necrosis factor	Homo sapiens	118-151
19180800-4	2003	Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively.	Tetradecanoylphorbol Acetate	39-70	interleukin 1 beta	Homo sapiens	153-175
19180800-4	2003	Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively.	Tetradecanoylphorbol Acetate	39-70	interleukin 6	Homo sapiens	180-184
19180800-4	2003	Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively.	Tetradecanoylphorbol Acetate	72-75	interleukin 1 beta	Homo sapiens	153-175
19180800-4	2003	Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively.	Tetradecanoylphorbol Acetate	72-75	interleukin 6	Homo sapiens	180-184
12882798-7	2003	12-O-tetradecanoyl-phorbol-13-acetate was effective in increasing the levels of proMMP-1, -3, and -9 and TIMP-1.	Tetradecanoylphorbol Acetate	0-37	TIMP metallopeptidase inhibitor 1	Homo sapiens	105-111
12811831-5	2003	The Ang II-induced proliferation of breast cancer cells was reduced by (a) Go6976, an inhibitor of conventional PKC-alpha and -beta1, (b) AG1478, an inhibitor of the tyrosine kinase of the EGF receptor (EGFR), and (c) downregulation of 1,2-diacylglycerol-sensitive PKCs achieved by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	282-313	angiotensinogen	Homo sapiens	4-10
12811831-5	2003	The Ang II-induced proliferation of breast cancer cells was reduced by (a) Go6976, an inhibitor of conventional PKC-alpha and -beta1, (b) AG1478, an inhibitor of the tyrosine kinase of the EGF receptor (EGFR), and (c) downregulation of 1,2-diacylglycerol-sensitive PKCs achieved by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	282-313	epidermal growth factor receptor	Homo sapiens	189-201
12919900-1	2003	OBJECTIVE: To investigate the role of p38 mitogen-activated protein kinase (MAPK) signal transduction pathways in regulating the in vitro invasion of JAR human choriocarcinoma cells induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	193-224	mitogen-activated protein kinase 14	Homo sapiens	38-41
12851698-0	2003	NAMI-A inhibits the PMA-induced ODC gene expression in ECV304 cells: involvement of PKC/Raf/Mek/ERK signalling pathway.	Tetradecanoylphorbol Acetate	20-23	proline rich transmembrane protein 2	Homo sapiens	84-87
12851698-0	2003	NAMI-A inhibits the PMA-induced ODC gene expression in ECV304 cells: involvement of PKC/Raf/Mek/ERK signalling pathway.	Tetradecanoylphorbol Acetate	20-23	mitogen-activated protein kinase kinase 7	Homo sapiens	92-95
12851698-0	2003	NAMI-A inhibits the PMA-induced ODC gene expression in ECV304 cells: involvement of PKC/Raf/Mek/ERK signalling pathway.	Tetradecanoylphorbol Acetate	20-23	mitogen-activated protein kinase 1	Homo sapiens	96-99
12799421-3	2003	In both cell types, GPI-ACE, but not WT-ACE, was sequestered in caveolin or flotillin-enriched lipid rafts and was released from the cell surface by treatment with phosphatidylinositol-specific phospholipase C. When cells were treated with activators of the protein kinase C signalling cascade (phorbol myristate acetate or carbachol) the shedding of GPI-ACE was stimulated to a similar extent to that of WT-ACE.	Tetradecanoylphorbol Acetate	295-320	angiotensin I converting enzyme	Homo sapiens	24-27
12811831-5	2003	The Ang II-induced proliferation of breast cancer cells was reduced by (a) Go6976, an inhibitor of conventional PKC-alpha and -beta1, (b) AG1478, an inhibitor of the tyrosine kinase of the EGF receptor (EGFR), and (c) downregulation of 1,2-diacylglycerol-sensitive PKCs achieved by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	315-318	epidermal growth factor receptor	Homo sapiens	189-201
12794177-8	2003	Both phorbol-12-myristate-13-acetate (PMA), which activates PKC and, in turn, ERK, and caffeine, which increases intracellular Ca2+ without eliciting contraction, increased HSL activity.	Tetradecanoylphorbol Acetate	5-36	Eph receptor B1	Rattus norvegicus	78-81
12734388-3	2003	Direct activation of PKC by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA) or 1,2-dioctanoyl-sn-glycerol (DOG) desensitized CRF1 receptors in Y79 cells, reducing the maximum for CRF- (but not forskolin)-stimulated cAMP accumulation by 56.3 +/- 1.2% and 40.4 +/- 2.1%, respectively (p &lt; 0.001).	Tetradecanoylphorbol Acetate	61-92	protein kinase C alpha	Homo sapiens	21-24
12734388-3	2003	Direct activation of PKC by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA) or 1,2-dioctanoyl-sn-glycerol (DOG) desensitized CRF1 receptors in Y79 cells, reducing the maximum for CRF- (but not forskolin)-stimulated cAMP accumulation by 56.3 +/- 1.2% and 40.4 +/- 2.1%, respectively (p &lt; 0.001).	Tetradecanoylphorbol Acetate	94-97	protein kinase C alpha	Homo sapiens	21-24
12734388-6	2003	When alpha and beta isoforms of PKC were down-regulated 80 to 90% by a 48-h PMA exposure, PMA-induced CRF1 receptor desensitization was abolished.	Tetradecanoylphorbol Acetate	76-79	protein kinase C alpha	Homo sapiens	32-35
12794177-8	2003	Both phorbol-12-myristate-13-acetate (PMA), which activates PKC and, in turn, ERK, and caffeine, which increases intracellular Ca2+ without eliciting contraction, increased HSL activity.	Tetradecanoylphorbol Acetate	38-41	Eph receptor B1	Rattus norvegicus	78-81
12880946-6	2003	In contrast, activation of protein kinase C (PKC) by phorbol myristyl acetate (PMA), mezerein or 1-oleoyl-2-acetyl-sn-glycerol (OAG) inhibited the influx of Ca2+ triggered by 4AP.	Tetradecanoylphorbol Acetate	79-82	proline rich transmembrane protein 2	Homo sapiens	27-43
12880946-6	2003	In contrast, activation of protein kinase C (PKC) by phorbol myristyl acetate (PMA), mezerein or 1-oleoyl-2-acetyl-sn-glycerol (OAG) inhibited the influx of Ca2+ triggered by 4AP.	Tetradecanoylphorbol Acetate	79-82	proline rich transmembrane protein 2	Homo sapiens	45-48
12962141-3	2003	These techniques allowed the observation of p105 cytosol-to-membrane translocation induced by TPA for the first time in hemocytes of molluscs.	Tetradecanoylphorbol Acetate	94-97	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-48
12850144-11	2003	Furthermore, ionomycin (calcium ionophore) and TPA augmented the enhancer activity of PSME, implying that calcium is an important regulator for PSMA expression in prostate cancer cell.	Tetradecanoylphorbol Acetate	47-50	folate hydrolase 1	Homo sapiens	144-148
12860389-1	2003	Prostaglandin (PG) E2 release is induced in pulmonary A549 cells by the NF-kappaB-activating stimuli interleukin-1beta (IL-1beta) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	134-165	nuclear factor kappa B subunit 1	Homo sapiens	72-81
12860383-2	2003	Phorbol-12-myristate-13-acetate (PMA) strongly enhanced the amplitude of Ca(v)3.2 channel currents (approximately 3-fold).	Tetradecanoylphorbol Acetate	0-31	caveolin 3, gene 2 S homeolog	Xenopus laevis	73-81
12860383-2	2003	Phorbol-12-myristate-13-acetate (PMA) strongly enhanced the amplitude of Ca(v)3.2 channel currents (approximately 3-fold).	Tetradecanoylphorbol Acetate	33-36	caveolin 3, gene 2 S homeolog	Xenopus laevis	73-81
12821145-7	2003	Peptide specific inhibitors for beta(II)PKC, and a general PKC inhibitor, calphostin C antagonized PMA-induced activation of I(Ks).	Tetradecanoylphorbol Acetate	99-102	proline rich transmembrane protein 2	Homo sapiens	59-62
12881712-5	2003	The expression of the death adapter FADD and caspase-8 was required for Fas-induced FOXO3a cleavage, but activation of survival pathways by overexpression of FLICE-inhibitory protein or phorbol myristate acetate treatment prevented it.	Tetradecanoylphorbol Acetate	186-211	forkhead box O3	Homo sapiens	84-90
12890576-4	2003	Phorbol myristicate ester (PMA), a protein kinase C (PKC) stimulator, increased the activity of NHE 1 whereas calphostin C, a PKC inhibitor, partially inhibited NHE 1 activation induced by adrenaline.	Tetradecanoylphorbol Acetate	27-30	solute carrier family 9 member A1	Homo sapiens	96-101
12890576-4	2003	Phorbol myristicate ester (PMA), a protein kinase C (PKC) stimulator, increased the activity of NHE 1 whereas calphostin C, a PKC inhibitor, partially inhibited NHE 1 activation induced by adrenaline.	Tetradecanoylphorbol Acetate	27-30	solute carrier family 9 member A1	Homo sapiens	161-166
12821145-9	2003	The present study demonstrates that beta(II)PKC, epsilon PKC but not beta(I)PKC, alphaPKC, deltaPKC, and etaPKC, are involved in PMA-induced activation of the cloned human I(Ks) expressed in Xenopus oocyte.	Tetradecanoylphorbol Acetate	129-132	proline rich transmembrane protein 2	Homo sapiens	44-47
14515485-6	2003	In the presence of the perfluoride emulsion, myeloperoxidase plays a more important role in the generation of luminescent responses in both N-formylmethionylleucylphenylalanine- and phorbol-12-myristate-13-acetate-stimulated neutrophils.	Tetradecanoylphorbol Acetate	182-213	myeloperoxidase	Homo sapiens	45-60
12730223-6	2003	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate stimulated PYK2 phosphorylation and MMP-13 production.	Tetradecanoylphorbol Acetate	37-68	matrix metallopeptidase 13	Homo sapiens	105-111
12730223-7	2003	MMP-13 expression stimulated by either phorbol 12-myristate 13-acetate or FN-f was blocked by PKC inhibitors including the PKCdelta inhibitor rottlerin.	Tetradecanoylphorbol Acetate	39-70	matrix metallopeptidase 13	Homo sapiens	0-6
12843260-0	2003	Phorbol myristate acetate-dependent interaction of protein kinase Calpha and the neuronal glutamate transporter EAAC1.	Tetradecanoylphorbol Acetate	0-25	solute carrier family 1 member 1	Homo sapiens	112-117
12843260-5	2003	In C6 glioma cells, activation of PKC with phorbol 12-myristate 13-acetate (PMA) induced formation of EAAC1-PKCalpha complexes but did not induce formation of complexes with PKCdelta, a PKC not thought to regulate EAAC1.	Tetradecanoylphorbol Acetate	43-74	protein kinase C alpha	Homo sapiens	34-37
12843260-5	2003	In C6 glioma cells, activation of PKC with phorbol 12-myristate 13-acetate (PMA) induced formation of EAAC1-PKCalpha complexes but did not induce formation of complexes with PKCdelta, a PKC not thought to regulate EAAC1.	Tetradecanoylphorbol Acetate	43-74	solute carrier family 1 member 1	Homo sapiens	102-107
12843260-5	2003	In C6 glioma cells, activation of PKC with phorbol 12-myristate 13-acetate (PMA) induced formation of EAAC1-PKCalpha complexes but did not induce formation of complexes with PKCdelta, a PKC not thought to regulate EAAC1.	Tetradecanoylphorbol Acetate	43-74	protein kinase C alpha	Homo sapiens	108-116
12843260-5	2003	In C6 glioma cells, activation of PKC with phorbol 12-myristate 13-acetate (PMA) induced formation of EAAC1-PKCalpha complexes but did not induce formation of complexes with PKCdelta, a PKC not thought to regulate EAAC1.	Tetradecanoylphorbol Acetate	43-74	protein kinase C alpha	Homo sapiens	108-111
12843260-5	2003	In C6 glioma cells, activation of PKC with phorbol 12-myristate 13-acetate (PMA) induced formation of EAAC1-PKCalpha complexes but did not induce formation of complexes with PKCdelta, a PKC not thought to regulate EAAC1.	Tetradecanoylphorbol Acetate	76-79	protein kinase C alpha	Homo sapiens	34-37
12843260-5	2003	In C6 glioma cells, activation of PKC with phorbol 12-myristate 13-acetate (PMA) induced formation of EAAC1-PKCalpha complexes but did not induce formation of complexes with PKCdelta, a PKC not thought to regulate EAAC1.	Tetradecanoylphorbol Acetate	76-79	solute carrier family 1 member 1	Homo sapiens	102-107
12843260-5	2003	In C6 glioma cells, activation of PKC with phorbol 12-myristate 13-acetate (PMA) induced formation of EAAC1-PKCalpha complexes but did not induce formation of complexes with PKCdelta, a PKC not thought to regulate EAAC1.	Tetradecanoylphorbol Acetate	76-79	protein kinase C alpha	Homo sapiens	108-116
12843260-5	2003	In C6 glioma cells, activation of PKC with phorbol 12-myristate 13-acetate (PMA) induced formation of EAAC1-PKCalpha complexes but did not induce formation of complexes with PKCdelta, a PKC not thought to regulate EAAC1.	Tetradecanoylphorbol Acetate	76-79	protein kinase C alpha	Homo sapiens	108-111
12843260-5	2003	In C6 glioma cells, activation of PKC with phorbol 12-myristate 13-acetate (PMA) induced formation of EAAC1-PKCalpha complexes but did not induce formation of complexes with PKCdelta, a PKC not thought to regulate EAAC1.	Tetradecanoylphorbol Acetate	76-79	solute carrier family 1 member 1	Homo sapiens	214-219
12856769-9	2003	RESULTS: Short-duration strenuous sled-pulling activity was associated with lower MPC concentration, higher MPCDW concentration, and higher cell-surface P-selectin expression after activation with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	197-222	selectin P	Canis lupus familiaris	153-163
12807762-5	2003	TPA exposure of IAR20 cells induced hyperphosphorylation of gap junction protein connexin43 and inhibition of GJIC.	Tetradecanoylphorbol Acetate	0-3	gap junction protein, alpha 1	Rattus norvegicus	81-91
12712434-5	2003	The activation of NF-kappaB through ligand-induced stimulation by tumor necrosis factor-alpha (TNF-alpha) or phorbol 12-myristate 13-acetate (PMA) was also inhibited by transient expression of LDOC1 in a dose dependent manner.	Tetradecanoylphorbol Acetate	109-140	nuclear factor kappa B subunit 1	Homo sapiens	18-27
12810581-5	2003	Phorbol 12-myristate 13-acetate (positive control) stimulated GLP-1 secretion to 252 +/- 38% of the control (P &lt; 0.001).	Tetradecanoylphorbol Acetate	0-31	glucagon	Homo sapiens	62-67
12712434-5	2003	The activation of NF-kappaB through ligand-induced stimulation by tumor necrosis factor-alpha (TNF-alpha) or phorbol 12-myristate 13-acetate (PMA) was also inhibited by transient expression of LDOC1 in a dose dependent manner.	Tetradecanoylphorbol Acetate	109-140	LDOC1 regulator of NFKB signaling	Homo sapiens	193-198
12712434-5	2003	The activation of NF-kappaB through ligand-induced stimulation by tumor necrosis factor-alpha (TNF-alpha) or phorbol 12-myristate 13-acetate (PMA) was also inhibited by transient expression of LDOC1 in a dose dependent manner.	Tetradecanoylphorbol Acetate	142-145	nuclear factor kappa B subunit 1	Homo sapiens	18-27
12712434-5	2003	The activation of NF-kappaB through ligand-induced stimulation by tumor necrosis factor-alpha (TNF-alpha) or phorbol 12-myristate 13-acetate (PMA) was also inhibited by transient expression of LDOC1 in a dose dependent manner.	Tetradecanoylphorbol Acetate	142-145	LDOC1 regulator of NFKB signaling	Homo sapiens	193-198
12758252-6	2003	Using human primary lymphocytes and Jurkat CD4(+) T cells stimulated with PMA/ionomycin, we demonstrate activation (phosphorylation) of JNK and p38, which is further confirmed by two additional established techniques (WB and confocal microscopy).	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 8	Homo sapiens	136-139
12890888-6	2003	Pretreatment with phorbol-12-myristate-13-acetate, which induces the expression of antiapoptotic Bcl-2, inhibited thapsigargin-induced degradation of caspases-9 and -3, but not caspase-12-like protein degradation.	Tetradecanoylphorbol Acetate	18-49	BCL2 apoptosis regulator	Homo sapiens	97-102
12792650-7	2003	Caspase-9 is phosphorylated at Thr 125, a conserved MAPK consensus site targeted by ERK2 in vitro, in a MEK-dependent manner in cells stimulated with epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	183-219	mitogen-activated protein kinase 1	Homo sapiens	52-56
12792650-7	2003	Caspase-9 is phosphorylated at Thr 125, a conserved MAPK consensus site targeted by ERK2 in vitro, in a MEK-dependent manner in cells stimulated with epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	183-219	mitogen-activated protein kinase 1	Homo sapiens	84-88
12792650-7	2003	Caspase-9 is phosphorylated at Thr 125, a conserved MAPK consensus site targeted by ERK2 in vitro, in a MEK-dependent manner in cells stimulated with epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	221-224	mitogen-activated protein kinase 1	Homo sapiens	84-88
12758252-6	2003	Using human primary lymphocytes and Jurkat CD4(+) T cells stimulated with PMA/ionomycin, we demonstrate activation (phosphorylation) of JNK and p38, which is further confirmed by two additional established techniques (WB and confocal microscopy).	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 14	Homo sapiens	144-147
12562561-2	2003	An activator of classical and novel isoforms of PKC, phorbol 12-myristate-13-acetate (PMA; 100 nM), inhibited CAT-1-mediated l-arginine transport in PAEC after a 1-h treatment and activated l-arginine uptake after an 18-h treatment of cells.	Tetradecanoylphorbol Acetate	53-84	protein kinase C alpha	Homo sapiens	48-51
14592552-3	2003	Collagen-stimulated platelet thromboxane B2 (TxB2) production and phorbol 12-myristate-13-acetate (PMA)-induced neutrophil prostaglandin E2 (PGE2) synthesis were used as indicators for COX-1 and COX-2 activity, respectively.	Tetradecanoylphorbol Acetate	99-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
12562561-2	2003	An activator of classical and novel isoforms of PKC, phorbol 12-myristate-13-acetate (PMA; 100 nM), inhibited CAT-1-mediated l-arginine transport in PAEC after a 1-h treatment and activated l-arginine uptake after an 18-h treatment of cells.	Tetradecanoylphorbol Acetate	86-89	protein kinase C alpha	Homo sapiens	48-51
12562561-4	2003	The inhibitory effect of PMA on l-arginine transport was accompanied by a translocation of PKCalpha (a classical PKC isoform) from the cytosol to the membrane fraction, whereas the activating effect of PMA on l-arginine transport was accompanied by full depletion of the expression of PKCalpha in PAEC.	Tetradecanoylphorbol Acetate	25-28	protein kinase C alpha	Homo sapiens	91-99
12562561-4	2003	The inhibitory effect of PMA on l-arginine transport was accompanied by a translocation of PKCalpha (a classical PKC isoform) from the cytosol to the membrane fraction, whereas the activating effect of PMA on l-arginine transport was accompanied by full depletion of the expression of PKCalpha in PAEC.	Tetradecanoylphorbol Acetate	25-28	protein kinase C alpha	Homo sapiens	91-94
12562561-4	2003	The inhibitory effect of PMA on l-arginine transport was accompanied by a translocation of PKCalpha (a classical PKC isoform) from the cytosol to the membrane fraction, whereas the activating effect of PMA on l-arginine transport was accompanied by full depletion of the expression of PKCalpha in PAEC.	Tetradecanoylphorbol Acetate	25-28	protein kinase C alpha	Homo sapiens	285-293
12562561-4	2003	The inhibitory effect of PMA on l-arginine transport was accompanied by a translocation of PKCalpha (a classical PKC isoform) from the cytosol to the membrane fraction, whereas the activating effect of PMA on l-arginine transport was accompanied by full depletion of the expression of PKCalpha in PAEC.	Tetradecanoylphorbol Acetate	202-205	protein kinase C alpha	Homo sapiens	285-293
12733059-0	2003	TPA-induced signal transduction: a link between PKC and EGFR signaling modulates the assembly of intercellular junctions in Caco-2 cells.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor receptor	Homo sapiens	56-60
12733059-10	2003	Potent specific EGFR inhibitors, such as PD153035 and Tyrphostin 25, as well as Calphostin C, an inhibitor of PKC, significantly blocked the effect of TPA on AJs.	Tetradecanoylphorbol Acetate	151-154	epidermal growth factor receptor	Homo sapiens	16-20
12733059-11	2003	Furthermore, inhibition of the TPA effect by the PD98059 MAPK inhibitor suggests that activation of this kinase was the final event in the modulation of cadherin-dependent cell-cell adhesion.	Tetradecanoylphorbol Acetate	31-34	cadherin 1	Homo sapiens	153-161
12801607-7	2003	Furthermore, stimulation of PKC, using short-term 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment, markedly inhibited the stimulatory effects of EGF on Akt phosphorylation.	Tetradecanoylphorbol Acetate	50-86	proline rich transmembrane protein 2	Homo sapiens	28-31
12801607-7	2003	Furthermore, stimulation of PKC, using short-term 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment, markedly inhibited the stimulatory effects of EGF on Akt phosphorylation.	Tetradecanoylphorbol Acetate	50-86	AKT serine/threonine kinase 1	Homo sapiens	157-160
12801607-7	2003	Furthermore, stimulation of PKC, using short-term 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment, markedly inhibited the stimulatory effects of EGF on Akt phosphorylation.	Tetradecanoylphorbol Acetate	88-91	proline rich transmembrane protein 2	Homo sapiens	28-31
12801607-7	2003	Furthermore, stimulation of PKC, using short-term 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment, markedly inhibited the stimulatory effects of EGF on Akt phosphorylation.	Tetradecanoylphorbol Acetate	88-91	AKT serine/threonine kinase 1	Homo sapiens	157-160
12782578-7	2003	Because Psl1 does not segregate in this cross, its effect on TPA promotion susceptibility is the same for all mice in the cross.	Tetradecanoylphorbol Acetate	61-64	promotion susceptibility QTL 1	Mus musculus	8-12
12782578-12	2003	Psl3 appears to have an additive affect, with heterozygous mice having a stronger response to TPA than mice homozygous for the DBA/2 allele and a weaker response to TPA than mice homozygous for the C57BL/6 allele.	Tetradecanoylphorbol Acetate	94-97	promotion susceptibility QTL 3	Mus musculus	0-4
12782578-12	2003	Psl3 appears to have an additive affect, with heterozygous mice having a stronger response to TPA than mice homozygous for the DBA/2 allele and a weaker response to TPA than mice homozygous for the C57BL/6 allele.	Tetradecanoylphorbol Acetate	165-168	promotion susceptibility QTL 3	Mus musculus	0-4
12782578-13	2003	Psl4 maps near D19Mit38 on distal chromosome 19 and inheritance of the dominant C57BL/6 allele results in decreased TPA sensitivity.	Tetradecanoylphorbol Acetate	116-119	promotion susceptibility QTL 4	Mus musculus	0-4
12733059-13	2003	Based on these results, we conclude that both EGFR and PKC activation are involved in TPA-induced cell signaling for modulation of cadherin-dependent cell-cell adhesion and cell shape in Caco-2 cells.	Tetradecanoylphorbol Acetate	86-89	epidermal growth factor receptor	Homo sapiens	46-50
12733059-13	2003	Based on these results, we conclude that both EGFR and PKC activation are involved in TPA-induced cell signaling for modulation of cadherin-dependent cell-cell adhesion and cell shape in Caco-2 cells.	Tetradecanoylphorbol Acetate	86-89	cadherin 1	Homo sapiens	131-139
12733059-3	2003	We used chemical activation of PKC and EGFR with 12- O-tetradecanoylphorbol-13-acetate (TPA), a tumor-promoting agent, pretreatment with protein kinase inhibitors and subcellular fractionation to analyze the effect of the phorbol ester on the redistribution of junctional proteins.	Tetradecanoylphorbol Acetate	88-91	epidermal growth factor receptor	Homo sapiens	39-43
12733059-6	2003	TPA affected E-cadherin levels.	Tetradecanoylphorbol Acetate	0-3	cadherin 1	Homo sapiens	13-23
12733059-7	2003	In Caco-2 cells at day 2 of culture, when most E-cadherin is not associated with the cytoskeleton, a decrease in the level of this protein was observed as soon as 6 h after TPA addition.	Tetradecanoylphorbol Acetate	173-176	cadherin 1	Homo sapiens	47-57
12875367-4	2003	Phorbol-12-myristate-13-acetate-(PMA)-treated THP-1 cells were exposed to the same conditions.	Tetradecanoylphorbol Acetate	0-31	GLI family zinc finger 2	Homo sapiens	46-51
12769672-8	2003	This technique was used to monitor the transcription patterns of mRNA encoding TNF-alpha, IL-1beta, and Interferon-gamma in human cell lines or primary PBMC treated with inducers such as PMA, ionomycin, and endotoxin.	Tetradecanoylphorbol Acetate	187-190	tumor necrosis factor	Homo sapiens	79-88
12769672-8	2003	This technique was used to monitor the transcription patterns of mRNA encoding TNF-alpha, IL-1beta, and Interferon-gamma in human cell lines or primary PBMC treated with inducers such as PMA, ionomycin, and endotoxin.	Tetradecanoylphorbol Acetate	187-190	interleukin 1 beta	Homo sapiens	90-98
12769672-8	2003	This technique was used to monitor the transcription patterns of mRNA encoding TNF-alpha, IL-1beta, and Interferon-gamma in human cell lines or primary PBMC treated with inducers such as PMA, ionomycin, and endotoxin.	Tetradecanoylphorbol Acetate	187-190	interferon gamma	Homo sapiens	104-120
12794411-8	2003	After phorbol 12-myristate 13-acetate stimulation, the number of IL-4-producing CD4+ cells increased three-fold in the trauma patients compared with healthy control subjects.	Tetradecanoylphorbol Acetate	6-37	interleukin 4	Homo sapiens	65-69
12875367-4	2003	Phorbol-12-myristate-13-acetate-(PMA)-treated THP-1 cells were exposed to the same conditions.	Tetradecanoylphorbol Acetate	33-36	GLI family zinc finger 2	Homo sapiens	46-51
12765200-10	2003	Resveratrol could inhibit PMA-induced IL-8 production in U937 cells at protein and mRNA levels.	Tetradecanoylphorbol Acetate	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
12738994-7	2003	Addition of phorbol 12-myristate 13-acetate, 1,2-diacyl-sn-glycerol, IFN-gamma, or IFN-alpha induced the expression of TFPI-2 wild-type promoter construct as well as TFPI-2 protein and mRNA in Hs683 cells.	Tetradecanoylphorbol Acetate	12-43	tissue factor pathway inhibitor 2	Homo sapiens	119-125
12738994-7	2003	Addition of phorbol 12-myristate 13-acetate, 1,2-diacyl-sn-glycerol, IFN-gamma, or IFN-alpha induced the expression of TFPI-2 wild-type promoter construct as well as TFPI-2 protein and mRNA in Hs683 cells.	Tetradecanoylphorbol Acetate	12-43	tissue factor pathway inhibitor 2	Homo sapiens	166-172
12739001-2	2003	When K562 cells were induced to differentiate into the megakaryocyte lineage by treatment with TPA, the expression of the c-ets-1, Fli-1 and TEL2 genes was increased, and that of the TEL gene was decreased at the onset of differentiation.	Tetradecanoylphorbol Acetate	95-98	ETS variant transcription factor 7	Homo sapiens	141-145
12739001-2	2003	When K562 cells were induced to differentiate into the megakaryocyte lineage by treatment with TPA, the expression of the c-ets-1, Fli-1 and TEL2 genes was increased, and that of the TEL gene was decreased at the onset of differentiation.	Tetradecanoylphorbol Acetate	95-98	ETS variant transcription factor 6	Homo sapiens	141-144
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Tetradecanoylphorbol Acetate	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
12773514-6	2003	Also, Lck and Fyn as well as MEK1/ERK and p38 MAPK were found to regulate MICA expression in anti-CD28/phorbol 12-myristate 13-acetate-stimulated T cells.	Tetradecanoylphorbol Acetate	103-134	mitogen-activated protein kinase 1	Homo sapiens	34-37
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Tetradecanoylphorbol Acetate	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Tetradecanoylphorbol Acetate	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Tetradecanoylphorbol Acetate	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
12869534-5	2003	The antibody recognized eNOS immunoprecipitated with anti-eNOS antibody from the soluble fraction of bovine aortic endothelial cells, and the immunoreactivity increased markedly when the cells were treated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	211-242	nitric oxide synthase 3	Bos taurus	24-28
12869534-5	2003	The antibody recognized eNOS immunoprecipitated with anti-eNOS antibody from the soluble fraction of bovine aortic endothelial cells, and the immunoreactivity increased markedly when the cells were treated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	211-242	nitric oxide synthase 3	Bos taurus	58-62
12773514-6	2003	Also, Lck and Fyn as well as MEK1/ERK and p38 MAPK were found to regulate MICA expression in anti-CD28/phorbol 12-myristate 13-acetate-stimulated T cells.	Tetradecanoylphorbol Acetate	103-134	mitogen-activated protein kinase 1	Homo sapiens	42-45
12646577-17	2003	Incadronate markedly enhanced the phosphorylation of Raf-1, MEK1/2, and p44/p42 MAPK induced by PGF2 alpha or 12-O-tetradecanoylphorbol-13-acetate, a PKC activator.	Tetradecanoylphorbol Acetate	110-146	mitogen-activated protein kinase 1	Mus musculus	76-84
12654926-3	2003	Transgenic keratinocytes had higher basal Erk activity and IL-1alpha levels than nontransgenic controls and were more sensitive to stimulation of Erk activity and IL-1alpha production by IL-1alpha, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), and serum.	Tetradecanoylphorbol Acetate	198-234	mitogen-activated protein kinase 1	Mus musculus	146-149
12654926-3	2003	Transgenic keratinocytes had higher basal Erk activity and IL-1alpha levels than nontransgenic controls and were more sensitive to stimulation of Erk activity and IL-1alpha production by IL-1alpha, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), and serum.	Tetradecanoylphorbol Acetate	236-239	mitogen-activated protein kinase 1	Mus musculus	146-149
12654926-6	2003	Inhibition of transactivation blocked basal and TPA or IL-1alpha induced Erk activation, but not IkappaBalpha degradation, and abolished increased IL-1alpha production in transgenic cells.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 1	Mus musculus	73-76
12590935-6	2003	In spite of their differences on transport, TeTx, TPA and NGF produce an increase in serotonin transporter phosphorylation in Ser separately, which is abolished by the PKC-inhibitor bisindolylmaleimide-1.	Tetradecanoylphorbol Acetate	50-53	solute carrier family 6 member 4	Rattus norvegicus	85-106
12729646-2	2003	In the t-Pa-induced fibrin clot lysis assay, several compounds inhibit the formation of the tPa-PAI-1 complex with submicromolar IC(50).	Tetradecanoylphorbol Acetate	92-95	plasminogen activator, tissue type	Homo sapiens	7-11
12522006-1	2003	Monocytic differentiation of 32DPKCdelta cells in response to activation of protein kinase C delta (PKCdelta) by phorbol 12-myristate 13-acetate (PMA) was inhibited by exogenous CCAAT/enhancer binding protein alpha-estradiol receptor (C/EBPalpha-ER), which impeded morphologic maturation and induction of macrosialin mRNA.	Tetradecanoylphorbol Acetate	146-149	CCAAT enhancer binding protein alpha	Homo sapiens	235-245
12727210-2	2003	Moreover, it has been reported that the transcription factors involved in p21(WAF-1) activation by certain signaling factors, like the phorbol ester TPA, may vary in different cell types.	Tetradecanoylphorbol Acetate	149-152	cyclin dependent kinase inhibitor 1A	Homo sapiens	74-77
12727210-2	2003	Moreover, it has been reported that the transcription factors involved in p21(WAF-1) activation by certain signaling factors, like the phorbol ester TPA, may vary in different cell types.	Tetradecanoylphorbol Acetate	149-152	cyclin dependent kinase inhibitor 1A	Homo sapiens	78-83
12727210-3	2003	We were interested in elucidating the mechanism of p21(WAF-1) activation by TPA in human T-cells, since this activation could explain the antagonistic effect of PKC on apoptosis induction in these cells noted in our previous studies.	Tetradecanoylphorbol Acetate	76-79	cyclin dependent kinase inhibitor 1A	Homo sapiens	51-54
12727210-3	2003	We were interested in elucidating the mechanism of p21(WAF-1) activation by TPA in human T-cells, since this activation could explain the antagonistic effect of PKC on apoptosis induction in these cells noted in our previous studies.	Tetradecanoylphorbol Acetate	76-79	cyclin dependent kinase inhibitor 1A	Homo sapiens	55-60
12727210-3	2003	We were interested in elucidating the mechanism of p21(WAF-1) activation by TPA in human T-cells, since this activation could explain the antagonistic effect of PKC on apoptosis induction in these cells noted in our previous studies.	Tetradecanoylphorbol Acetate	76-79	proline rich transmembrane protein 2	Homo sapiens	161-164
12727210-4	2003	Using the Jurkat human T-cells we found that TPA activated p21(WAF-1) expression by a PKC-dependent mechanism and that out of six Sp1 binding sites residing in its promoter the second most upstream one was critically essential for this activation.	Tetradecanoylphorbol Acetate	45-48	cyclin dependent kinase inhibitor 1A	Homo sapiens	59-62
12727210-4	2003	Using the Jurkat human T-cells we found that TPA activated p21(WAF-1) expression by a PKC-dependent mechanism and that out of six Sp1 binding sites residing in its promoter the second most upstream one was critically essential for this activation.	Tetradecanoylphorbol Acetate	45-48	cyclin dependent kinase inhibitor 1A	Homo sapiens	63-68
12727210-4	2003	Using the Jurkat human T-cells we found that TPA activated p21(WAF-1) expression by a PKC-dependent mechanism and that out of six Sp1 binding sites residing in its promoter the second most upstream one was critically essential for this activation.	Tetradecanoylphorbol Acetate	45-48	proline rich transmembrane protein 2	Homo sapiens	86-89
12522006-1	2003	Monocytic differentiation of 32DPKCdelta cells in response to activation of protein kinase C delta (PKCdelta) by phorbol 12-myristate 13-acetate (PMA) was inhibited by exogenous CCAAT/enhancer binding protein alpha-estradiol receptor (C/EBPalpha-ER), which impeded morphologic maturation and induction of macrosialin mRNA.	Tetradecanoylphorbol Acetate	113-144	CCAAT enhancer binding protein alpha	Homo sapiens	235-245
12640676-9	2003	Additionally, some TPA-induced genes, such as Sprr1A, Saa3, JunB, Il4ralpha, Gp38, RalGDS and Slpi exhibit high basal level in advanced stages of skin carcinogenesis, suggesting that at least a subgroup of the identified TPA-regulated genes may contribute to tumour progression and metastasis.	Tetradecanoylphorbol Acetate	19-22	small proline-rich protein 1A	Mus musculus	46-52
12734380-4	2003	Inhibition of Akt activity in human neutrophils by an inhibitory peptide significantly attenuated fMLP-stimulated, but not PMA-stimulated, superoxide release.	Tetradecanoylphorbol Acetate	123-126	AKT serine/threonine kinase 1	Homo sapiens	14-17
12640676-9	2003	Additionally, some TPA-induced genes, such as Sprr1A, Saa3, JunB, Il4ralpha, Gp38, RalGDS and Slpi exhibit high basal level in advanced stages of skin carcinogenesis, suggesting that at least a subgroup of the identified TPA-regulated genes may contribute to tumour progression and metastasis.	Tetradecanoylphorbol Acetate	19-22	serum amyloid A 3	Mus musculus	54-58
12611888-6	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA) and lysophosphatidic acid (LPA) are also potent inducers of pro-HB-EGF shedding in Vero cells.	Tetradecanoylphorbol Acetate	0-36	proheparin-binding EGF-like growth factor	Chlorocebus sabaeus	107-113
12611888-6	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA) and lysophosphatidic acid (LPA) are also potent inducers of pro-HB-EGF shedding in Vero cells.	Tetradecanoylphorbol Acetate	38-41	proheparin-binding EGF-like growth factor	Chlorocebus sabaeus	107-113
12595531-9	2003	Furthermore, T cells treated with soluble anti-TCR antibody produced IL-2 when phorbol 12-myristate 13-acetate, which activates ERK, was present in the culture medium 2-6 h after the start of stimulation.	Tetradecanoylphorbol Acetate	79-110	interleukin 2	Homo sapiens	69-73
12595531-9	2003	Furthermore, T cells treated with soluble anti-TCR antibody produced IL-2 when phorbol 12-myristate 13-acetate, which activates ERK, was present in the culture medium 2-6 h after the start of stimulation.	Tetradecanoylphorbol Acetate	79-110	mitogen-activated protein kinase 1	Homo sapiens	128-131
12801911-6	2003	Also, nuclear translocation of ERK induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by SB 239063, which does not associate with c-Raf and is highly selective for p38 MAP kinase.	Tetradecanoylphorbol Acetate	46-83	mitogen-activated protein kinase 1	Homo sapiens	31-34
12748876-4	2003	In addition, granulosa cells obtained from the follicular fluid were cultured and treated with forskolin and 12- o-tetradecanoylphorbol 13-acetate for 24-48 h. The concentration of IL-6 was significantly higher in the follicular fluid than in the serum (P&lt;0.01).	Tetradecanoylphorbol Acetate	109-146	interleukin 6	Homo sapiens	181-185
12707382-11	2003	Furthermore, the acute activation of protein kinase C by phorbol 12-myristate 13-acetate similarly stimulated JHCO(3)(-) in WT and AT1A KO, indicating that the inhibitory and stimulatory pathways necessary for the AngII actions were preserved in AT(1A) KO.	Tetradecanoylphorbol Acetate	57-88	angiotensin II receptor, type 1a	Mus musculus	131-135
12707382-11	2003	Furthermore, the acute activation of protein kinase C by phorbol 12-myristate 13-acetate similarly stimulated JHCO(3)(-) in WT and AT1A KO, indicating that the inhibitory and stimulatory pathways necessary for the AngII actions were preserved in AT(1A) KO.	Tetradecanoylphorbol Acetate	57-88	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	214-219
12684678-3	2003	In the present studies, we determined the effect of high intracellular levels of the anti-apoptosis Bcl-2 protein on caspase 3 activation and cyctochrome c release during phorbol ester 12-myristate 13-acetate (PMA)-induced apoptosis.	Tetradecanoylphorbol Acetate	210-213	BCL2 apoptosis regulator	Homo sapiens	100-105
12684678-7	2003	Treatment with 20 nM PMA for 24 h produced morphological features of apoptosis and DNA fragmentation in U937 and U937/Bcl-2 cells, but not in R-U937 cells.	Tetradecanoylphorbol Acetate	21-24	BCL2 apoptosis regulator	Homo sapiens	118-123
12801911-6	2003	Also, nuclear translocation of ERK induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by SB 239063, which does not associate with c-Raf and is highly selective for p38 MAP kinase.	Tetradecanoylphorbol Acetate	46-83	mitogen-activated protein kinase 14	Homo sapiens	182-185
12740021-7	2003	In addition, cAMP and TPA reduced the surface membrane labeling for Cx43, whereas staurosporin increased it.	Tetradecanoylphorbol Acetate	22-25	gap junction protein, alpha 1	Mus musculus	68-72
12801911-6	2003	Also, nuclear translocation of ERK induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by SB 239063, which does not associate with c-Raf and is highly selective for p38 MAP kinase.	Tetradecanoylphorbol Acetate	85-88	mitogen-activated protein kinase 1	Homo sapiens	31-34
12801911-6	2003	Also, nuclear translocation of ERK induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by SB 239063, which does not associate with c-Raf and is highly selective for p38 MAP kinase.	Tetradecanoylphorbol Acetate	85-88	mitogen-activated protein kinase 14	Homo sapiens	182-185
12801911-7	2003	In addition, the forced expression of the dominant negative mutant of p38 MAP kinase suppressed serum responsive element-dependent transactivation induced by TPA.	Tetradecanoylphorbol Acetate	158-161	mitogen-activated protein kinase 14	Homo sapiens	70-73
12694376-4	2003	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a PKC activator, markedly promoted lamellipodia formation, while safingol (a PKC alpha-selective inhibitor) blocked the TPA-induced lamellipodial actin structure.	Tetradecanoylphorbol Acetate	15-51	protein kinase C alpha	Homo sapiens	61-64
12707358-2	2003	A protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or a Src kinase inhibitor (PP2) attenuated TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 promoter activity.	Tetradecanoylphorbol Acetate	166-202	protein kinase C alpha	Homo sapiens	20-23
12707358-3	2003	TNF-alpha- or TPA-induced I-kappaB kinase (IKK) activation was also blocked by these inhibitors, which reversed I-kappaBalpha degradation.	Tetradecanoylphorbol Acetate	14-17	NFKB inhibitor alpha	Homo sapiens	112-125
12707358-5	2003	The dominant-negative c-Src (KM) mutant inhibited induction of COX-2 promoter activity by TNF-alpha or TPA.	Tetradecanoylphorbol Acetate	103-106	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	22-27
12707358-5	2003	The dominant-negative c-Src (KM) mutant inhibited induction of COX-2 promoter activity by TNF-alpha or TPA.	Tetradecanoylphorbol Acetate	103-106	prostaglandin-endoperoxide synthase 2	Homo sapiens	63-68
12707358-10	2003	Substitution of these residues with phenylalanines attenuated COX-2 promoter activity and c-Src-dependent phosphorylation of IKKbeta induced by TNF-alpha or TPA.	Tetradecanoylphorbol Acetate	157-160	prostaglandin-endoperoxide synthase 2	Homo sapiens	62-67
12707358-10	2003	Substitution of these residues with phenylalanines attenuated COX-2 promoter activity and c-Src-dependent phosphorylation of IKKbeta induced by TNF-alpha or TPA.	Tetradecanoylphorbol Acetate	157-160	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-95
12694376-5	2003	Both wound-healing and Boyden migration assays showed that TPA treatment promoted neuronal migration of GT1 cells; however, cotreatment of TPA with safingol or rottlerin (a PKC delta-selective inhibitor) clearly blocked this TPA effect, indicating that both PKC alpha and PKC delta may be positive regulators of neuronal migration.	Tetradecanoylphorbol Acetate	139-142	protein kinase C alpha	Homo sapiens	258-267
12694376-7	2003	Among the PKC downstream signal molecules, p130Cas, a mediator of cell migration, and its kinase, focal adhesion kinase (FAK), increased following TPA treatment; phosphorylation of p130Cas was induced in a PKC alpha-dependent manner.	Tetradecanoylphorbol Acetate	147-150	protein kinase C alpha	Homo sapiens	10-13
12694376-4	2003	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a PKC activator, markedly promoted lamellipodia formation, while safingol (a PKC alpha-selective inhibitor) blocked the TPA-induced lamellipodial actin structure.	Tetradecanoylphorbol Acetate	53-56	protein kinase C alpha	Homo sapiens	61-64
12694376-7	2003	Among the PKC downstream signal molecules, p130Cas, a mediator of cell migration, and its kinase, focal adhesion kinase (FAK), increased following TPA treatment; phosphorylation of p130Cas was induced in a PKC alpha-dependent manner.	Tetradecanoylphorbol Acetate	147-150	protein kinase C alpha	Homo sapiens	206-215
12694376-4	2003	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a PKC activator, markedly promoted lamellipodia formation, while safingol (a PKC alpha-selective inhibitor) blocked the TPA-induced lamellipodial actin structure.	Tetradecanoylphorbol Acetate	179-182	protein kinase C alpha	Homo sapiens	136-145
12694376-5	2003	Both wound-healing and Boyden migration assays showed that TPA treatment promoted neuronal migration of GT1 cells; however, cotreatment of TPA with safingol or rottlerin (a PKC delta-selective inhibitor) clearly blocked this TPA effect, indicating that both PKC alpha and PKC delta may be positive regulators of neuronal migration.	Tetradecanoylphorbol Acetate	59-62	protein kinase C alpha	Homo sapiens	258-267
12694376-5	2003	Both wound-healing and Boyden migration assays showed that TPA treatment promoted neuronal migration of GT1 cells; however, cotreatment of TPA with safingol or rottlerin (a PKC delta-selective inhibitor) clearly blocked this TPA effect, indicating that both PKC alpha and PKC delta may be positive regulators of neuronal migration.	Tetradecanoylphorbol Acetate	139-142	protein kinase C alpha	Homo sapiens	258-267
12748306-6	2003	Primary murine keratinocytes (newborn keratinocytes) and skin homogenates were used to characterize TPA-stimulated TNF-alpha expression.	Tetradecanoylphorbol Acetate	100-103	tumor necrosis factor	Mus musculus	115-124
12748306-7	2003	TPA induced TNF-alpha protein in newborn keratinocytes in vitro and epidermis in vivo.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Mus musculus	12-21
12748306-8	2003	Neutralization of TNF-alpha protein with cV1q in vivo for 0-15 weeks of promotion significantly decreased skin tumor development after 9,10-dimethyl-1,2-benzanthracene/TPA treatment.	Tetradecanoylphorbol Acetate	168-171	tumor necrosis factor	Mus musculus	18-27
12748306-11	2003	cV1q also reduced TPA-stimulated expression of matrix metalloproteinase 9 and granulocyte macrophage colony-stimulating factor, proteins that are differentially regulated in wt and TNF-alpha(-/-) epidermis.	Tetradecanoylphorbol Acetate	18-21	tumor necrosis factor	Mus musculus	181-190
12706826-1	2003	Earlier studies showed that treatment of LA-N-1 cells with TPA, a tumoral promoter, leads to the stimulation of a G protein-regulated phospholipase D (PLD) in the nuclei.	Tetradecanoylphorbol Acetate	59-62	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	134-149
12590140-6	2003	The binding of KLF6 to the iNOS promoter was significantly increased in Jurkat cells, primary T lymphocytes, and COS-7 cells subjected to NaCN-induced hypoxia, heat shock, serum starvation, and phorbol 12-myristate 13-acetate/ ionophore stimulation.	Tetradecanoylphorbol Acetate	194-225	nitric oxide synthase 2	Homo sapiens	27-31
12706826-1	2003	Earlier studies showed that treatment of LA-N-1 cells with TPA, a tumoral promoter, leads to the stimulation of a G protein-regulated phospholipase D (PLD) in the nuclei.	Tetradecanoylphorbol Acetate	59-62	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	151-154
12693948-11	2003	Indeed, PD98059 and SB203580, two selective inhibitors of MEK1/2 and p38MAPK, respectively, inhibited p67(PHOX) phosphorylation in fMLP- and PMA-stimulated neutrophils, with additive effects, thus suggesting that they also target different sites in vivo.	Tetradecanoylphorbol Acetate	141-144	CD33 molecule	Homo sapiens	102-105
12693944-4	2003	The osteoblast-like cell line MG-63 was pretreated with calphostin C, a PKC inhibitor, or phorbol 12-myristate 13-acetate (PMA) for an extended period, a condition which causes PKC downregulation, and subsequently with AA.	Tetradecanoylphorbol Acetate	90-121	protein kinase C alpha	Homo sapiens	177-180
12670703-1	2003	Several treatments which regulate tyrosine hydroxylase (TH) transcription, such as stress in vivo, or 12-O-tetradecanoylphorbol-13-acetate (TPA) in cell culture, induce both Egr1 and AP1 factors.	Tetradecanoylphorbol Acetate	102-138	early growth response 1	Rattus norvegicus	174-178
12693944-4	2003	The osteoblast-like cell line MG-63 was pretreated with calphostin C, a PKC inhibitor, or phorbol 12-myristate 13-acetate (PMA) for an extended period, a condition which causes PKC downregulation, and subsequently with AA.	Tetradecanoylphorbol Acetate	123-126	protein kinase C alpha	Homo sapiens	177-180
12647293-3	2003	We observed a PMA-stimulated intact cell phosphorylation of Galpha(15) in COS7 cells transfected with Galpha(15) and protein kinase Calpha (PKCalpha), and phosphorylation of endogenous Galpha(16) in HL60 cells.	Tetradecanoylphorbol Acetate	14-17	guanine nucleotide binding protein, alpha 15	Mus musculus	60-70
12647293-3	2003	We observed a PMA-stimulated intact cell phosphorylation of Galpha(15) in COS7 cells transfected with Galpha(15) and protein kinase Calpha (PKCalpha), and phosphorylation of endogenous Galpha(16) in HL60 cells.	Tetradecanoylphorbol Acetate	14-17	guanine nucleotide binding protein, alpha 15	Mus musculus	102-112
12670703-1	2003	Several treatments which regulate tyrosine hydroxylase (TH) transcription, such as stress in vivo, or 12-O-tetradecanoylphorbol-13-acetate (TPA) in cell culture, induce both Egr1 and AP1 factors.	Tetradecanoylphorbol Acetate	140-143	early growth response 1	Rattus norvegicus	174-178
12714245-4	2003	The production of IL-2 and IFN-gamma by the different subpopulations was studied following stimulation with PMA and Ionomycin.	Tetradecanoylphorbol Acetate	108-111	interferon gamma	Homo sapiens	27-36
12559815-4	2003	The antioxidant capacities of each biomaterial were assessed by their inhibition of O(2)*- -induced cytochrome C reduction, generated via PMN stimulation by phorbol myristyl acetate (PMA); and their inhibition of *OH-induced 2-deoxy-D-ribose degradation, generated by PMA stimulated PMN in the presence of a ferric chloride-EDTA chelate.	Tetradecanoylphorbol Acetate	183-186	cytochrome c, somatic	Homo sapiens	100-112
12765533-1	2003	The effect of the phorbol ester phorbol 12-myristate 13-acetate (PMA) on expression of the human interferon (IFN)-inducible tryptophanyl-tRNA synthetase (WRS) gene was studied.	Tetradecanoylphorbol Acetate	32-63	tryptophanyl-tRNA synthetase 1	Homo sapiens	124-152
12765533-1	2003	The effect of the phorbol ester phorbol 12-myristate 13-acetate (PMA) on expression of the human interferon (IFN)-inducible tryptophanyl-tRNA synthetase (WRS) gene was studied.	Tetradecanoylphorbol Acetate	32-63	tryptophanyl-tRNA synthetase 1	Homo sapiens	154-157
12765533-1	2003	The effect of the phorbol ester phorbol 12-myristate 13-acetate (PMA) on expression of the human interferon (IFN)-inducible tryptophanyl-tRNA synthetase (WRS) gene was studied.	Tetradecanoylphorbol Acetate	65-68	tryptophanyl-tRNA synthetase 1	Homo sapiens	124-152
12765533-1	2003	The effect of the phorbol ester phorbol 12-myristate 13-acetate (PMA) on expression of the human interferon (IFN)-inducible tryptophanyl-tRNA synthetase (WRS) gene was studied.	Tetradecanoylphorbol Acetate	65-68	tryptophanyl-tRNA synthetase 1	Homo sapiens	154-157
12765533-2	2003	PMA caused an increase in the basal and IFNgamma-induced WRS protein content in HeLa and HEK293 cultured cells.	Tetradecanoylphorbol Acetate	0-3	interferon gamma	Homo sapiens	40-48
12765533-2	2003	PMA caused an increase in the basal and IFNgamma-induced WRS protein content in HeLa and HEK293 cultured cells.	Tetradecanoylphorbol Acetate	0-3	tryptophanyl-tRNA synthetase 1	Homo sapiens	57-60
12752124-10	2003	Phorbol myristate acetate (PMA), tumour necrosis factor alpha, and interferon gamma each activated NF-kappaB and inhibited keratinocyte proliferation.	Tetradecanoylphorbol Acetate	0-25	nuclear factor kappa B subunit 1	Homo sapiens	99-108
12752124-10	2003	Phorbol myristate acetate (PMA), tumour necrosis factor alpha, and interferon gamma each activated NF-kappaB and inhibited keratinocyte proliferation.	Tetradecanoylphorbol Acetate	27-30	nuclear factor kappa B subunit 1	Homo sapiens	99-108
12651162-8	2003	HEK293 cells stably overexpressing Trespin display increased cell proliferation and partial resistance to growth inhibition and phosphorylation of c-Jun induced by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	182-218	serpin family B member 10	Rattus norvegicus	35-42
12651162-8	2003	HEK293 cells stably overexpressing Trespin display increased cell proliferation and partial resistance to growth inhibition and phosphorylation of c-Jun induced by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	220-223	serpin family B member 10	Rattus norvegicus	35-42
12660227-3	2003	Hypoxia/reoxygenation strongly activated nuclear factor-kappaB (NF-kappaB) in synovial fibroblasts to the levels produced by phorbol 12-myristate 13-acetate and caused lymphocyte hyperadhesiveness to synovial fibroblasts as well as up-regulation of ICAM-1, both of which were completely blocked by a NF-kappaB antagonist (pyrrolidine dithiocarbamate).	Tetradecanoylphorbol Acetate	125-156	nuclear factor kappa B subunit 1	Homo sapiens	41-62
12660227-3	2003	Hypoxia/reoxygenation strongly activated nuclear factor-kappaB (NF-kappaB) in synovial fibroblasts to the levels produced by phorbol 12-myristate 13-acetate and caused lymphocyte hyperadhesiveness to synovial fibroblasts as well as up-regulation of ICAM-1, both of which were completely blocked by a NF-kappaB antagonist (pyrrolidine dithiocarbamate).	Tetradecanoylphorbol Acetate	125-156	nuclear factor kappa B subunit 1	Homo sapiens	64-73
12656657-3	2003	After the analysis of the lymphocyte sub-populations, the intracellular content of interferon-gamma (IFN-gamma) in phorbolmyristate acetate (PMA)-stimulated CD4+ and CD8+ lymphocytes was assayed.	Tetradecanoylphorbol Acetate	115-139	interferon gamma	Homo sapiens	83-99
12656657-3	2003	After the analysis of the lymphocyte sub-populations, the intracellular content of interferon-gamma (IFN-gamma) in phorbolmyristate acetate (PMA)-stimulated CD4+ and CD8+ lymphocytes was assayed.	Tetradecanoylphorbol Acetate	115-139	interferon gamma	Homo sapiens	101-110
12656657-3	2003	After the analysis of the lymphocyte sub-populations, the intracellular content of interferon-gamma (IFN-gamma) in phorbolmyristate acetate (PMA)-stimulated CD4+ and CD8+ lymphocytes was assayed.	Tetradecanoylphorbol Acetate	115-139	CD4 molecule	Homo sapiens	157-160
12656657-3	2003	After the analysis of the lymphocyte sub-populations, the intracellular content of interferon-gamma (IFN-gamma) in phorbolmyristate acetate (PMA)-stimulated CD4+ and CD8+ lymphocytes was assayed.	Tetradecanoylphorbol Acetate	141-144	interferon gamma	Homo sapiens	83-99
12656657-3	2003	After the analysis of the lymphocyte sub-populations, the intracellular content of interferon-gamma (IFN-gamma) in phorbolmyristate acetate (PMA)-stimulated CD4+ and CD8+ lymphocytes was assayed.	Tetradecanoylphorbol Acetate	141-144	interferon gamma	Homo sapiens	101-110
12656657-3	2003	After the analysis of the lymphocyte sub-populations, the intracellular content of interferon-gamma (IFN-gamma) in phorbolmyristate acetate (PMA)-stimulated CD4+ and CD8+ lymphocytes was assayed.	Tetradecanoylphorbol Acetate	141-144	CD4 molecule	Homo sapiens	157-160
12654469-5	2003	Antioxidants vitamin E and pyrrolidine dithiocarbamate (PDTC) and antioxidizing enzymes catalase and superoxide dismutase (SOD) effectively blocked phorbol myristate acetate- (PMA-) and lyso phosphatidic acid- (LPA-) induced synthesis of Gp.	Tetradecanoylphorbol Acetate	148-173	catalase	Homo sapiens	88-96
12654469-5	2003	Antioxidants vitamin E and pyrrolidine dithiocarbamate (PDTC) and antioxidizing enzymes catalase and superoxide dismutase (SOD) effectively blocked phorbol myristate acetate- (PMA-) and lyso phosphatidic acid- (LPA-) induced synthesis of Gp.	Tetradecanoylphorbol Acetate	176-179	catalase	Homo sapiens	88-96
12618484-8	2003	In addition to the interaction and intracellular co-localization of the CIS and PKC, an increase in the activation of AP-1 and NF-kappaB was noted in CIS-expressing T cells, after stimulation by either anti-CD3/CD28 or phorbol myristate acetate + ionomycin.	Tetradecanoylphorbol Acetate	219-244	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	127-136
12646136-5	2003	We isolated 50 suppressors that contain mutations in tpa-1, which encodes two protein kinase C isoforms, TPA-1A and TPA-1B, most similar to PKCtheta/delta.	Tetradecanoylphorbol Acetate	105-108	Protein kinase C-like 1	Caenorhabditis elegans	53-58
12646136-5	2003	We isolated 50 suppressors that contain mutations in tpa-1, which encodes two protein kinase C isoforms, TPA-1A and TPA-1B, most similar to PKCtheta/delta.	Tetradecanoylphorbol Acetate	116-119	Protein kinase C-like 1	Caenorhabditis elegans	53-58
12626585-3	2003	Pretreatment of macrophages with PMA or the proinflammatory mediators LPS and TNF-alpha blocks IL-6-induced STAT3 activation, whereas IL-10-induced activation of STAT3 remains largely unaffected.	Tetradecanoylphorbol Acetate	33-36	interleukin 6	Homo sapiens	95-99
12626585-3	2003	Pretreatment of macrophages with PMA or the proinflammatory mediators LPS and TNF-alpha blocks IL-6-induced STAT3 activation, whereas IL-10-induced activation of STAT3 remains largely unaffected.	Tetradecanoylphorbol Acetate	33-36	signal transducer and activator of transcription 3	Homo sapiens	108-113
12645577-2	2003	TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ICAM-1 promoter activity was inhibited by a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2).	Tetradecanoylphorbol Acetate	14-50	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	222-225
12645577-2	2003	TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ICAM-1 promoter activity was inhibited by a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2).	Tetradecanoylphorbol Acetate	52-55	tumor necrosis factor	Homo sapiens	0-9
12645577-2	2003	TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ICAM-1 promoter activity was inhibited by a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2).	Tetradecanoylphorbol Acetate	52-55	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	222-225
12645577-3	2003	TNF-alpha- or TPA-induced IkappaBalpha kinase (IKK) activation was also blocked by these inhibitors, which slightly reversed TNF-alpha-induced but completely reversed TPA-induced IkappaBalpha degradation.	Tetradecanoylphorbol Acetate	14-17	NFKB inhibitor alpha	Homo sapiens	26-38
12645577-3	2003	TNF-alpha- or TPA-induced IkappaBalpha kinase (IKK) activation was also blocked by these inhibitors, which slightly reversed TNF-alpha-induced but completely reversed TPA-induced IkappaBalpha degradation.	Tetradecanoylphorbol Acetate	14-17	tumor necrosis factor	Homo sapiens	125-134
12645577-3	2003	TNF-alpha- or TPA-induced IkappaBalpha kinase (IKK) activation was also blocked by these inhibitors, which slightly reversed TNF-alpha-induced but completely reversed TPA-induced IkappaBalpha degradation.	Tetradecanoylphorbol Acetate	14-17	NFKB inhibitor alpha	Homo sapiens	179-191
12645577-3	2003	TNF-alpha- or TPA-induced IkappaBalpha kinase (IKK) activation was also blocked by these inhibitors, which slightly reversed TNF-alpha-induced but completely reversed TPA-induced IkappaBalpha degradation.	Tetradecanoylphorbol Acetate	167-170	tumor necrosis factor	Homo sapiens	0-9
12645577-3	2003	TNF-alpha- or TPA-induced IkappaBalpha kinase (IKK) activation was also blocked by these inhibitors, which slightly reversed TNF-alpha-induced but completely reversed TPA-induced IkappaBalpha degradation.	Tetradecanoylphorbol Acetate	167-170	NFKB inhibitor alpha	Homo sapiens	26-38
12645577-3	2003	TNF-alpha- or TPA-induced IkappaBalpha kinase (IKK) activation was also blocked by these inhibitors, which slightly reversed TNF-alpha-induced but completely reversed TPA-induced IkappaBalpha degradation.	Tetradecanoylphorbol Acetate	167-170	NFKB inhibitor alpha	Homo sapiens	179-191
12645577-4	2003	c-Src and Lyn, two members of the Src kinase family, were abundantly expressed in A549 cells, and their activation by TNF-alpha or TPA was inhibited by the same inhibitors.	Tetradecanoylphorbol Acetate	131-134	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-5
12645577-4	2003	c-Src and Lyn, two members of the Src kinase family, were abundantly expressed in A549 cells, and their activation by TNF-alpha or TPA was inhibited by the same inhibitors.	Tetradecanoylphorbol Acetate	131-134	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	10-13
12645577-4	2003	c-Src and Lyn, two members of the Src kinase family, were abundantly expressed in A549 cells, and their activation by TNF-alpha or TPA was inhibited by the same inhibitors.	Tetradecanoylphorbol Acetate	131-134	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	2-5
12645577-5	2003	Furthermore, the dominant-negative c-Src (KM) mutant inhibited induction of ICAM-1 promoter activity by TNF-alpha or TPA.	Tetradecanoylphorbol Acetate	117-120	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	35-40
12633561-7	2003	After stimulation with PMA, n-BT, PAF and n-BT + PAF, the COX-2 expression in NSCLC cells was significantly increased in all cell lines.	Tetradecanoylphorbol Acetate	23-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
12633561-8	2003	CONCLUSIONS: The expression of COX-2 in NSCLC cells is high and was up-regulated by PMA, n-BT and PAF.	Tetradecanoylphorbol Acetate	84-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-36
14754536-5	2003	RESULTS: In the non-infection model, the activation of non-myeloperoxidase-mediated system with PMA stimulation in cord blood was lower compared with that in adult blood, the statistical difference was significant (t = 3.378, P &lt; 0.01).	Tetradecanoylphorbol Acetate	96-99	myeloperoxidase	Homo sapiens	59-74
12551910-2	2003	In the present study, we report that protection from Fas-induced apoptosis by 12-O-tetradecanoylphorbol 13-acetate (TPA) is dependent on both ERK and NF kappa B activation.	Tetradecanoylphorbol Acetate	78-114	mitogen-activated protein kinase 1	Homo sapiens	142-145
12551910-2	2003	In the present study, we report that protection from Fas-induced apoptosis by 12-O-tetradecanoylphorbol 13-acetate (TPA) is dependent on both ERK and NF kappa B activation.	Tetradecanoylphorbol Acetate	78-114	nuclear factor kappa B subunit 1	Homo sapiens	150-160
12551910-2	2003	In the present study, we report that protection from Fas-induced apoptosis by 12-O-tetradecanoylphorbol 13-acetate (TPA) is dependent on both ERK and NF kappa B activation.	Tetradecanoylphorbol Acetate	116-119	mitogen-activated protein kinase 1	Homo sapiens	142-145
12551910-2	2003	In the present study, we report that protection from Fas-induced apoptosis by 12-O-tetradecanoylphorbol 13-acetate (TPA) is dependent on both ERK and NF kappa B activation.	Tetradecanoylphorbol Acetate	116-119	nuclear factor kappa B subunit 1	Homo sapiens	150-160
12551910-3	2003	First, we showed that two specific mitogen-activated protein kinase/ERK kinase-inhibitors, PD98059 and U0126, both counteracted TPA-mediated suppression of Fas-induced apoptosis.	Tetradecanoylphorbol Acetate	128-131	mitogen-activated protein kinase 1	Homo sapiens	68-71
12551910-4	2003	Moreover, the dose-dependence of U0126-mediated inhibition of ERK phosphorylation correlated with that of reversion of the anti-apoptotic effect of TPA.	Tetradecanoylphorbol Acetate	148-151	mitogen-activated protein kinase 1	Homo sapiens	62-65
12551910-5	2003	Second, we observed an excellent correlation between repression of TPA-induced NF kappa B activation by an irreversible inhibitor of I kappa B alpha phosphorylation, BAY11-7082, and its ability to abrogate TPA-induced suppression of Fas-mediated apoptosis.	Tetradecanoylphorbol Acetate	67-70	nuclear factor kappa B subunit 1	Homo sapiens	79-89
12551910-5	2003	Second, we observed an excellent correlation between repression of TPA-induced NF kappa B activation by an irreversible inhibitor of I kappa B alpha phosphorylation, BAY11-7082, and its ability to abrogate TPA-induced suppression of Fas-mediated apoptosis.	Tetradecanoylphorbol Acetate	67-70	NFKB inhibitor alpha	Homo sapiens	133-148
12551910-5	2003	Second, we observed an excellent correlation between repression of TPA-induced NF kappa B activation by an irreversible inhibitor of I kappa B alpha phosphorylation, BAY11-7082, and its ability to abrogate TPA-induced suppression of Fas-mediated apoptosis.	Tetradecanoylphorbol Acetate	206-209	nuclear factor kappa B subunit 1	Homo sapiens	79-89
12551910-5	2003	Second, we observed an excellent correlation between repression of TPA-induced NF kappa B activation by an irreversible inhibitor of I kappa B alpha phosphorylation, BAY11-7082, and its ability to abrogate TPA-induced suppression of Fas-mediated apoptosis.	Tetradecanoylphorbol Acetate	206-209	NFKB inhibitor alpha	Homo sapiens	133-148
12551910-8	2003	Together these findings suggest that TPA-induced activation of ERK and NF kappa B are parallel events that are both required for maximal inhibition of Fas-induced apoptosis in Jurkat T cells.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 1	Homo sapiens	63-66
12551910-8	2003	Together these findings suggest that TPA-induced activation of ERK and NF kappa B are parallel events that are both required for maximal inhibition of Fas-induced apoptosis in Jurkat T cells.	Tetradecanoylphorbol Acetate	37-40	nuclear factor kappa B subunit 1	Homo sapiens	71-81
12623129-9	2003	Iloprost-induced COX-2 protein expression and PGI(2) formation was synergistically elevated by co-stimulation with the phorbolester PMA (phorbol-12-myristate-13-acetate).	Tetradecanoylphorbol Acetate	132-135	prostaglandin-endoperoxide synthase 2	Homo sapiens	17-22
12623129-9	2003	Iloprost-induced COX-2 protein expression and PGI(2) formation was synergistically elevated by co-stimulation with the phorbolester PMA (phorbol-12-myristate-13-acetate).	Tetradecanoylphorbol Acetate	137-168	prostaglandin-endoperoxide synthase 2	Homo sapiens	17-22
12506120-4	2003	Here we show that both endogenous and recombinant PKCnu are trans-located to the plasma membrane and activated by the diacylglycerol mimic phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	139-170	proline rich transmembrane protein 2	Homo sapiens	50-55
12645577-10	2003	Substitution of these residues with phenylalanines abolished ICAM-1 promoter activity and c-Src-dependent phosphorylation of IKKbeta induced by TNF-alpha or TPA.	Tetradecanoylphorbol Acetate	157-160	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-95
12600864-6	2003	ADP and phorbol 12-myristate 13-acetate-induced platelet aggregation, nitric oxide (NO) release, activation of endothelial constitutive nitric-oxide synthase (ecNOS; EC 1.14.13.39) and of protein kinase C (PKC), and ecNOS, superoxide dismutase (SOD; EC 1.15.1.1), and PKC protein content in platelets were measured before and after 8 wk of administration of tocopherols.	Tetradecanoylphorbol Acetate	8-39	nitric oxide synthase 3	Homo sapiens	111-157
12600864-6	2003	ADP and phorbol 12-myristate 13-acetate-induced platelet aggregation, nitric oxide (NO) release, activation of endothelial constitutive nitric-oxide synthase (ecNOS; EC 1.14.13.39) and of protein kinase C (PKC), and ecNOS, superoxide dismutase (SOD; EC 1.15.1.1), and PKC protein content in platelets were measured before and after 8 wk of administration of tocopherols.	Tetradecanoylphorbol Acetate	8-39	nitric oxide synthase 3	Homo sapiens	159-164
12600864-6	2003	ADP and phorbol 12-myristate 13-acetate-induced platelet aggregation, nitric oxide (NO) release, activation of endothelial constitutive nitric-oxide synthase (ecNOS; EC 1.14.13.39) and of protein kinase C (PKC), and ecNOS, superoxide dismutase (SOD; EC 1.15.1.1), and PKC protein content in platelets were measured before and after 8 wk of administration of tocopherols.	Tetradecanoylphorbol Acetate	8-39	nitric oxide synthase 3	Homo sapiens	216-221
12600864-6	2003	ADP and phorbol 12-myristate 13-acetate-induced platelet aggregation, nitric oxide (NO) release, activation of endothelial constitutive nitric-oxide synthase (ecNOS; EC 1.14.13.39) and of protein kinase C (PKC), and ecNOS, superoxide dismutase (SOD; EC 1.15.1.1), and PKC protein content in platelets were measured before and after 8 wk of administration of tocopherols.	Tetradecanoylphorbol Acetate	8-39	superoxide dismutase 1	Homo sapiens	223-243
12600864-6	2003	ADP and phorbol 12-myristate 13-acetate-induced platelet aggregation, nitric oxide (NO) release, activation of endothelial constitutive nitric-oxide synthase (ecNOS; EC 1.14.13.39) and of protein kinase C (PKC), and ecNOS, superoxide dismutase (SOD; EC 1.15.1.1), and PKC protein content in platelets were measured before and after 8 wk of administration of tocopherols.	Tetradecanoylphorbol Acetate	8-39	superoxide dismutase 1	Homo sapiens	245-248
12620479-7	2003	RESULT(S): Phorbol 12-myristate 13-acetate elicited an increase in MMP-9 and TIMP-1 secretion in both groups and apparently did not affect progesterone secretion.	Tetradecanoylphorbol Acetate	11-42	TIMP metallopeptidase inhibitor 1	Homo sapiens	77-83
12618484-8	2003	In addition to the interaction and intracellular co-localization of the CIS and PKC, an increase in the activation of AP-1 and NF-kappaB was noted in CIS-expressing T cells, after stimulation by either anti-CD3/CD28 or phorbol myristate acetate + ionomycin.	Tetradecanoylphorbol Acetate	219-244	protein kinase C, alpha	Mus musculus	80-83
12618484-8	2003	In addition to the interaction and intracellular co-localization of the CIS and PKC, an increase in the activation of AP-1 and NF-kappaB was noted in CIS-expressing T cells, after stimulation by either anti-CD3/CD28 or phorbol myristate acetate + ionomycin.	Tetradecanoylphorbol Acetate	219-244	cytokine inducible SH2-containing protein	Mus musculus	150-153
12594296-5	2003	PMA-induced O(2)(-) release assayed by cytochrome c was 3.4-fold higher in atopic human eosinophils than in neutrophils, although membrane-permeable dihydrorhodamine-123 showed similar amounts of release.	Tetradecanoylphorbol Acetate	0-3	cytochrome c, somatic	Homo sapiens	39-51
12576215-6	2003	When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	166-197	tumor necrosis factor	Homo sapiens	47-80
12576215-6	2003	When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	166-197	interleukin 1 beta	Homo sapiens	82-104
12594296-7	2003	In eosinophils stimulated with PMA, a pronounced shift of cytosolic Rac to p22(phox)-positive plasma membrane was observed by confocal microscopy, whereas neutrophils directed Rac2 mainly to intracellular sites coexpressing p22(phox).	Tetradecanoylphorbol Acetate	31-34	AKT serine/threonine kinase 1	Homo sapiens	68-71
12576215-6	2003	When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	166-197	interleukin 6	Homo sapiens	109-113
12576215-6	2003	When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	199-202	tumor necrosis factor	Homo sapiens	47-80
12594296-7	2003	In eosinophils stimulated with PMA, a pronounced shift of cytosolic Rac to p22(phox)-positive plasma membrane was observed by confocal microscopy, whereas neutrophils directed Rac2 mainly to intracellular sites coexpressing p22(phox).	Tetradecanoylphorbol Acetate	31-34	Rac family small GTPase 2	Homo sapiens	176-180
12576215-6	2003	When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	199-202	interleukin 6	Homo sapiens	109-113
12688321-3	2003	Pretreatment with phorbol 12-myristate 13-acetate (PMA), an activator of PKC, prevented TNF-alpha-induced rapid onset of apoptosis, which occurs at 3 h culture with TNF-alpha, concomitantly with the up-regulation of c-Myc protein expression.	Tetradecanoylphorbol Acetate	18-49	tumor necrosis factor	Homo sapiens	88-97
12688321-3	2003	Pretreatment with phorbol 12-myristate 13-acetate (PMA), an activator of PKC, prevented TNF-alpha-induced rapid onset of apoptosis, which occurs at 3 h culture with TNF-alpha, concomitantly with the up-regulation of c-Myc protein expression.	Tetradecanoylphorbol Acetate	18-49	tumor necrosis factor	Homo sapiens	165-174
12688321-3	2003	Pretreatment with phorbol 12-myristate 13-acetate (PMA), an activator of PKC, prevented TNF-alpha-induced rapid onset of apoptosis, which occurs at 3 h culture with TNF-alpha, concomitantly with the up-regulation of c-Myc protein expression.	Tetradecanoylphorbol Acetate	51-54	tumor necrosis factor	Homo sapiens	88-97
12688321-3	2003	Pretreatment with phorbol 12-myristate 13-acetate (PMA), an activator of PKC, prevented TNF-alpha-induced rapid onset of apoptosis, which occurs at 3 h culture with TNF-alpha, concomitantly with the up-regulation of c-Myc protein expression.	Tetradecanoylphorbol Acetate	51-54	tumor necrosis factor	Homo sapiens	165-174
12688321-4	2003	In addition, PMA enhanced TNF-a-induced differentiation at 24h treatment.	Tetradecanoylphorbol Acetate	13-16	tumor necrosis factor	Homo sapiens	26-31
12688321-7	2003	Up-regulation of c-Myc protein evoked by pretreatment with PMA for a short time could disturb the signaling pathway of the ceramide and sphingosine, which are known to function as the endogenous modulators mediating the apoptotic signal of TNF-alpha.	Tetradecanoylphorbol Acetate	59-62	tumor necrosis factor	Homo sapiens	240-249
12606037-4	2003	Overexpression of arfaptin 1, a 39 kDa ARF-binding protein that inhibits in vitro activation of cholera toxin ADP-ribosyltransferase and phospholipase D (PLD) by ARF, inhibited PMA-stimulated MMP-9 and PLD activation.	Tetradecanoylphorbol Acetate	177-180	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	154-157
12646286-8	2003	Phorbol-12-myristate-13-acetate (PMA, 10 nM), a PKC activator also increased I(Gly) and reduced ethanol potentiation of I(Gly).	Tetradecanoylphorbol Acetate	0-31	protein kinase C, epsilon	Rattus norvegicus	48-51
12646286-8	2003	Phorbol-12-myristate-13-acetate (PMA, 10 nM), a PKC activator also increased I(Gly) and reduced ethanol potentiation of I(Gly).	Tetradecanoylphorbol Acetate	33-36	protein kinase C, epsilon	Rattus norvegicus	48-51
12646286-9	2003	In addition, GF109203X (0.2 microM), a PKC inhibitor antagonized the potentiation effects produced either by PMA or by ethanol.	Tetradecanoylphorbol Acetate	109-112	protein kinase C, epsilon	Rattus norvegicus	39-42
12593797-6	2003	Jurkat cells activated their JNK in response to phorbol myristate acetate (PMA), and the response of the entire population of Jurkat cells was graded.	Tetradecanoylphorbol Acetate	48-73	mitogen-activated protein kinase 8	Homo sapiens	29-32
12493778-4	2003	We have found MEKK1 to be necessary for uPA up-regulation in response to treatment with phorbol 12-myristate 13-acetate or basic fibroblast growth factor.	Tetradecanoylphorbol Acetate	88-119	plasminogen activator, urokinase	Homo sapiens	40-43
12598935-4	2003	Pretreatment with L-Arg (100 micromol/L) decreased significantly Ang II -activated PKC activity and PKC activity induced by phorbol 12-myristate 13-acetate (PMA) ( 10 micromol/L), a PKC activator.	Tetradecanoylphorbol Acetate	124-155	angiotensinogen	Rattus norvegicus	65-71
12598935-4	2003	Pretreatment with L-Arg (100 micromol/L) decreased significantly Ang II -activated PKC activity and PKC activity induced by phorbol 12-myristate 13-acetate (PMA) ( 10 micromol/L), a PKC activator.	Tetradecanoylphorbol Acetate	157-160	angiotensinogen	Rattus norvegicus	65-71
12592382-0	2003	ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.	Tetradecanoylphorbol Acetate	107-110	mitogen-activated protein kinase 1	Homo sapiens	0-3
12592382-0	2003	ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.	Tetradecanoylphorbol Acetate	107-110	cyclin dependent kinase inhibitor 2B	Homo sapiens	37-45
12592382-0	2003	ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.	Tetradecanoylphorbol Acetate	107-110	cyclin dependent kinase inhibitor 2A	Homo sapiens	46-54
12592382-1	2003	The signal pathway mediating induction of p15(INK4b) and p16(INK4a) during HepG2 growth inhibition triggered by the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol 13-acetate) and the Chinese herb Saikosaponin a was investigated.	Tetradecanoylphorbol Acetate	145-148	cyclin dependent kinase inhibitor 2B	Homo sapiens	42-45
12592382-1	2003	The signal pathway mediating induction of p15(INK4b) and p16(INK4a) during HepG2 growth inhibition triggered by the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol 13-acetate) and the Chinese herb Saikosaponin a was investigated.	Tetradecanoylphorbol Acetate	145-148	cyclin dependent kinase inhibitor 2B	Homo sapiens	46-51
12592382-3	2003	During this period, phosphorylation of one of the downstream transcriptional factors of MAPK cascade, ATF2, was 3.2- and 2.0-fold induced by TPA and Saikosaponin a, respectively, whereas that of another transcriptional factor, c-jun, was induced by TPA only.	Tetradecanoylphorbol Acetate	249-252	mitogen-activated protein kinase 1	Homo sapiens	88-92
12592382-4	2003	On the other hand, expressions of proto-oncogene c-jun, junB and c-fos were induced by TPA and Saikosaponin a during 30 min to 6 h of treatment.	Tetradecanoylphorbol Acetate	87-90	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	56-60
12592382-5	2003	Pretreatment of 20 microg/ml PD98059, an inhibitor of MEK which is the upstream kinase of ERK, prevents the TPA- and Saikosaponin a-triggered HepG2 growth inhibition by 50 and 30%, respectively, accompanied by a 50 - 85% decrease of the p15(INK4b)/p16(INK4a) RNAs and proteins induced by both drugs.	Tetradecanoylphorbol Acetate	108-111	mitogen-activated protein kinase kinase 7	Homo sapiens	54-57
12592382-5	2003	Pretreatment of 20 microg/ml PD98059, an inhibitor of MEK which is the upstream kinase of ERK, prevents the TPA- and Saikosaponin a-triggered HepG2 growth inhibition by 50 and 30%, respectively, accompanied by a 50 - 85% decrease of the p15(INK4b)/p16(INK4a) RNAs and proteins induced by both drugs.	Tetradecanoylphorbol Acetate	108-111	mitogen-activated protein kinase 1	Homo sapiens	90-93
12592382-5	2003	Pretreatment of 20 microg/ml PD98059, an inhibitor of MEK which is the upstream kinase of ERK, prevents the TPA- and Saikosaponin a-triggered HepG2 growth inhibition by 50 and 30%, respectively, accompanied by a 50 - 85% decrease of the p15(INK4b)/p16(INK4a) RNAs and proteins induced by both drugs.	Tetradecanoylphorbol Acetate	108-111	cyclin dependent kinase inhibitor 2B	Homo sapiens	237-240
12592382-5	2003	Pretreatment of 20 microg/ml PD98059, an inhibitor of MEK which is the upstream kinase of ERK, prevents the TPA- and Saikosaponin a-triggered HepG2 growth inhibition by 50 and 30%, respectively, accompanied by a 50 - 85% decrease of the p15(INK4b)/p16(INK4a) RNAs and proteins induced by both drugs.	Tetradecanoylphorbol Acetate	108-111	cyclin dependent kinase inhibitor 2B	Homo sapiens	241-246
12592382-1	2003	The signal pathway mediating induction of p15(INK4b) and p16(INK4a) during HepG2 growth inhibition triggered by the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol 13-acetate) and the Chinese herb Saikosaponin a was investigated.	Tetradecanoylphorbol Acetate	145-148	cyclin dependent kinase inhibitor 2A	Homo sapiens	57-60
12592382-1	2003	The signal pathway mediating induction of p15(INK4b) and p16(INK4a) during HepG2 growth inhibition triggered by the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol 13-acetate) and the Chinese herb Saikosaponin a was investigated.	Tetradecanoylphorbol Acetate	145-148	cyclin dependent kinase inhibitor 2A	Homo sapiens	61-66
12592382-1	2003	The signal pathway mediating induction of p15(INK4b) and p16(INK4a) during HepG2 growth inhibition triggered by the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol 13-acetate) and the Chinese herb Saikosaponin a was investigated.	Tetradecanoylphorbol Acetate	150-186	cyclin dependent kinase inhibitor 2B	Homo sapiens	42-45
12592382-1	2003	The signal pathway mediating induction of p15(INK4b) and p16(INK4a) during HepG2 growth inhibition triggered by the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol 13-acetate) and the Chinese herb Saikosaponin a was investigated.	Tetradecanoylphorbol Acetate	150-186	cyclin dependent kinase inhibitor 2B	Homo sapiens	46-51
12592382-1	2003	The signal pathway mediating induction of p15(INK4b) and p16(INK4a) during HepG2 growth inhibition triggered by the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol 13-acetate) and the Chinese herb Saikosaponin a was investigated.	Tetradecanoylphorbol Acetate	150-186	cyclin dependent kinase inhibitor 2A	Homo sapiens	57-60
12592382-1	2003	The signal pathway mediating induction of p15(INK4b) and p16(INK4a) during HepG2 growth inhibition triggered by the phorbol ester tumor promoter TPA (12-O-tetradecanoylphorbol 13-acetate) and the Chinese herb Saikosaponin a was investigated.	Tetradecanoylphorbol Acetate	150-186	cyclin dependent kinase inhibitor 2A	Homo sapiens	61-66
12592382-2	2003	Western blot of three activated forms of mitogen-activated protein kinase (MAPK) (p-ERK, p-JNK and p-p38) demonstrated that phosphorylation of ERK is dramatically induced (11.6-fold ) by TPA during 15 min to 1 h and significantly induced (2.5-fold) by Saikosaponin alpha at 30 min, whereas phosphorylation of JNK was induced only by TPA during 30 min to 1 h. Phosphorylation of p38 was not induced by either drug.	Tetradecanoylphorbol Acetate	187-190	mitogen-activated protein kinase 1	Homo sapiens	75-79
12593797-6	2003	Jurkat cells activated their JNK in response to phorbol myristate acetate (PMA), and the response of the entire population of Jurkat cells was graded.	Tetradecanoylphorbol Acetate	75-78	mitogen-activated protein kinase 8	Homo sapiens	29-32
12592382-2	2003	Western blot of three activated forms of mitogen-activated protein kinase (MAPK) (p-ERK, p-JNK and p-p38) demonstrated that phosphorylation of ERK is dramatically induced (11.6-fold ) by TPA during 15 min to 1 h and significantly induced (2.5-fold) by Saikosaponin alpha at 30 min, whereas phosphorylation of JNK was induced only by TPA during 30 min to 1 h. Phosphorylation of p38 was not induced by either drug.	Tetradecanoylphorbol Acetate	187-190	mitogen-activated protein kinase 8	Homo sapiens	91-94
12592382-2	2003	Western blot of three activated forms of mitogen-activated protein kinase (MAPK) (p-ERK, p-JNK and p-p38) demonstrated that phosphorylation of ERK is dramatically induced (11.6-fold ) by TPA during 15 min to 1 h and significantly induced (2.5-fold) by Saikosaponin alpha at 30 min, whereas phosphorylation of JNK was induced only by TPA during 30 min to 1 h. Phosphorylation of p38 was not induced by either drug.	Tetradecanoylphorbol Acetate	187-190	mitogen-activated protein kinase 14	Homo sapiens	101-104
12592382-5	2003	Pretreatment of 20 microg/ml PD98059, an inhibitor of MEK which is the upstream kinase of ERK, prevents the TPA- and Saikosaponin a-triggered HepG2 growth inhibition by 50 and 30%, respectively, accompanied by a 50 - 85% decrease of the p15(INK4b)/p16(INK4a) RNAs and proteins induced by both drugs.	Tetradecanoylphorbol Acetate	108-111	cyclin dependent kinase inhibitor 2A	Homo sapiens	248-251
12446695-3	2003	Nrf2 has previously been found to undergo nuclear translocation by a phosphorylation-dependent mechanism mediated by protein kinase C in HepG2 cells treated with tert-butylhydroquinone, beta-naphthoflavone, or 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	210-246	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
12592382-5	2003	Pretreatment of 20 microg/ml PD98059, an inhibitor of MEK which is the upstream kinase of ERK, prevents the TPA- and Saikosaponin a-triggered HepG2 growth inhibition by 50 and 30%, respectively, accompanied by a 50 - 85% decrease of the p15(INK4b)/p16(INK4a) RNAs and proteins induced by both drugs.	Tetradecanoylphorbol Acetate	108-111	cyclin dependent kinase inhibitor 2A	Homo sapiens	252-257
12757776-7	2003	Luciferase activity consistently increased after stimulation of JEG-3 cells by phorbol 12-myristate 13-acetate indicating that NF1, NF-kappa B and egr-1/Sp1 binding sites are crucial in inducible TFPI-2 expression.	Tetradecanoylphorbol Acetate	79-110	neurofibromin 1	Homo sapiens	127-130
12757776-7	2003	Luciferase activity consistently increased after stimulation of JEG-3 cells by phorbol 12-myristate 13-acetate indicating that NF1, NF-kappa B and egr-1/Sp1 binding sites are crucial in inducible TFPI-2 expression.	Tetradecanoylphorbol Acetate	79-110	nuclear factor kappa B subunit 1	Homo sapiens	132-142
12592382-2	2003	Western blot of three activated forms of mitogen-activated protein kinase (MAPK) (p-ERK, p-JNK and p-p38) demonstrated that phosphorylation of ERK is dramatically induced (11.6-fold ) by TPA during 15 min to 1 h and significantly induced (2.5-fold) by Saikosaponin alpha at 30 min, whereas phosphorylation of JNK was induced only by TPA during 30 min to 1 h. Phosphorylation of p38 was not induced by either drug.	Tetradecanoylphorbol Acetate	187-190	mitogen-activated protein kinase 1	Homo sapiens	84-87
12592382-2	2003	Western blot of three activated forms of mitogen-activated protein kinase (MAPK) (p-ERK, p-JNK and p-p38) demonstrated that phosphorylation of ERK is dramatically induced (11.6-fold ) by TPA during 15 min to 1 h and significantly induced (2.5-fold) by Saikosaponin alpha at 30 min, whereas phosphorylation of JNK was induced only by TPA during 30 min to 1 h. Phosphorylation of p38 was not induced by either drug.	Tetradecanoylphorbol Acetate	187-190	mitogen-activated protein kinase 8	Homo sapiens	309-312
12592382-2	2003	Western blot of three activated forms of mitogen-activated protein kinase (MAPK) (p-ERK, p-JNK and p-p38) demonstrated that phosphorylation of ERK is dramatically induced (11.6-fold ) by TPA during 15 min to 1 h and significantly induced (2.5-fold) by Saikosaponin alpha at 30 min, whereas phosphorylation of JNK was induced only by TPA during 30 min to 1 h. Phosphorylation of p38 was not induced by either drug.	Tetradecanoylphorbol Acetate	187-190	mitogen-activated protein kinase 14	Homo sapiens	378-381
12592382-2	2003	Western blot of three activated forms of mitogen-activated protein kinase (MAPK) (p-ERK, p-JNK and p-p38) demonstrated that phosphorylation of ERK is dramatically induced (11.6-fold ) by TPA during 15 min to 1 h and significantly induced (2.5-fold) by Saikosaponin alpha at 30 min, whereas phosphorylation of JNK was induced only by TPA during 30 min to 1 h. Phosphorylation of p38 was not induced by either drug.	Tetradecanoylphorbol Acetate	333-336	mitogen-activated protein kinase 1	Homo sapiens	75-79
12592382-3	2003	During this period, phosphorylation of one of the downstream transcriptional factors of MAPK cascade, ATF2, was 3.2- and 2.0-fold induced by TPA and Saikosaponin a, respectively, whereas that of another transcriptional factor, c-jun, was induced by TPA only.	Tetradecanoylphorbol Acetate	141-144	mitogen-activated protein kinase 1	Homo sapiens	88-92
12757776-7	2003	Luciferase activity consistently increased after stimulation of JEG-3 cells by phorbol 12-myristate 13-acetate indicating that NF1, NF-kappa B and egr-1/Sp1 binding sites are crucial in inducible TFPI-2 expression.	Tetradecanoylphorbol Acetate	79-110	tissue factor pathway inhibitor 2	Homo sapiens	196-202
12393739-5	2003	Adhesion of CD34(+)CD38(-) cells to laminin-10/11 was maximal without integrin activation, whereas adhesion to other proteins was dependent on protein kinase C activation by 12-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	211-214	CD34 molecule	Homo sapiens	12-16
12675201-8	2003	In addition, PUAE (0.1 and 1 mg/mL) inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	126-157	tumor necrosis factor	Homo sapiens	63-90
12584172-3	2003	We investigated the mutagenic potentials of 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated differentiated HL-60 (human promyelocytic leukemia cells), and RAW 264.7 cells (murine macrophages) stimulated with lipopolysaccharide (LPS) and interferon (IFN)-gamma by co-culturing each cell line with AS52 cells, a transgenic Chinese hamster ovary cell line.	Tetradecanoylphorbol Acetate	82-85	toll-like receptor 4	Mus musculus	234-237
12584172-3	2003	We investigated the mutagenic potentials of 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated differentiated HL-60 (human promyelocytic leukemia cells), and RAW 264.7 cells (murine macrophages) stimulated with lipopolysaccharide (LPS) and interferon (IFN)-gamma by co-culturing each cell line with AS52 cells, a transgenic Chinese hamster ovary cell line.	Tetradecanoylphorbol Acetate	82-85	interferon gamma	Mus musculus	243-265
12584172-5	2003	RAW 264.7 cells stimulated with LPS and IFN-gamma produced O(2)(-), nitric oxide (NO) and peroxynitrite (ONOO(-)) continuously for 5-25 h. There was a 2.0-fold increase in the mutation frequency of the gpt gene in AS52 cells co-cultured with TPA stimulated HL-60 cells, when compared with non-treated cells.	Tetradecanoylphorbol Acetate	242-245	toll-like receptor 4	Mus musculus	32-35
12584172-5	2003	RAW 264.7 cells stimulated with LPS and IFN-gamma produced O(2)(-), nitric oxide (NO) and peroxynitrite (ONOO(-)) continuously for 5-25 h. There was a 2.0-fold increase in the mutation frequency of the gpt gene in AS52 cells co-cultured with TPA stimulated HL-60 cells, when compared with non-treated cells.	Tetradecanoylphorbol Acetate	242-245	interferon gamma	Mus musculus	40-49
12588317-7	2003	TGF-beta mRNA and protein were up-regulated when the cells were stimulated with PHA/TPA.	Tetradecanoylphorbol Acetate	84-87	transforming growth factor beta 1	Homo sapiens	0-8
12581266-8	2003	After controlling for age, both PAI-1 and tPA-PAI-1 showed significant negative correlations with HDL-cholesterol, and positive correlations with triglycerides, WHR, HbA1 and fibrinogen.	Tetradecanoylphorbol Acetate	42-45	fibrinogen beta chain	Homo sapiens	175-185
12675201-8	2003	In addition, PUAE (0.1 and 1 mg/mL) inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	126-157	interleukin 6	Homo sapiens	104-122
12675201-8	2003	In addition, PUAE (0.1 and 1 mg/mL) inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	159-162	tumor necrosis factor	Homo sapiens	63-90
12675201-8	2003	In addition, PUAE (0.1 and 1 mg/mL) inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	159-162	interleukin 6	Homo sapiens	104-122
12542530-10	2003	Finally, immunohistochemistry demonstrated an inhibition in the production of the pro-inflammatory cytokines interleukin-1alpha and tumor necrosis factor alpha in the oxysterol-treated sites from both TPA- and oxazolone-treated animals.	Tetradecanoylphorbol Acetate	201-204	tumor necrosis factor	Mus musculus	132-159
12669231-9	2003	The expression of CD14 and MPO in HL-60 leukemia cells overexpressing GMPR2 clearly increased after induction by TPA.	Tetradecanoylphorbol Acetate	113-116	myeloperoxidase	Homo sapiens	27-30
12669231-9	2003	The expression of CD14 and MPO in HL-60 leukemia cells overexpressing GMPR2 clearly increased after induction by TPA.	Tetradecanoylphorbol Acetate	113-116	guanosine monophosphate reductase 2	Homo sapiens	70-75
12519122-5	2003	In neural crest cells, TPA was found to be necessary for both microphthalmia associated transcription factor (Mitf) up-regulation and for melanin synthesis.	Tetradecanoylphorbol Acetate	23-26	melanogenesis associated transcription factor	Mus musculus	62-108
12569271-6	2003	Lucigenin-derived ROS generation was significantly increased in neutrophils isolated from women with pre-eclampsia compared with normotensive controls in the case of both agonists [n-formyl-met-leu-phe (fMLP): pre-eclamptic 2.071 +/- 0.336 relative light units seconds (RLU.s) and normotensive 1.141 +/- 0.249 RLU.s, P = 0.035; phorbol-12-myristate-13-acetate (PMA): pre-eclamptic 34.954 +/- 2.634 RLU.s and normotensive 17.208 +/- 3.325 RLU.s, P = 0.0001].	Tetradecanoylphorbol Acetate	328-359	formyl peptide receptor 1	Homo sapiens	203-207
12569271-6	2003	Lucigenin-derived ROS generation was significantly increased in neutrophils isolated from women with pre-eclampsia compared with normotensive controls in the case of both agonists [n-formyl-met-leu-phe (fMLP): pre-eclamptic 2.071 +/- 0.336 relative light units seconds (RLU.s) and normotensive 1.141 +/- 0.249 RLU.s, P = 0.035; phorbol-12-myristate-13-acetate (PMA): pre-eclamptic 34.954 +/- 2.634 RLU.s and normotensive 17.208 +/- 3.325 RLU.s, P = 0.0001].	Tetradecanoylphorbol Acetate	361-364	formyl peptide receptor 1	Homo sapiens	203-207
12631113-11	2003	Incubation of MCs with phorbol myristate acetate (PMA) for four hours resulted in an increase in fractalkine mRNA expression that could be suppressed by calphostin C or depletion of PKC by pretreatment with PMA for 24 hours.	Tetradecanoylphorbol Acetate	23-48	C-X3-C motif chemokine ligand 1	Homo sapiens	97-108
12631113-11	2003	Incubation of MCs with phorbol myristate acetate (PMA) for four hours resulted in an increase in fractalkine mRNA expression that could be suppressed by calphostin C or depletion of PKC by pretreatment with PMA for 24 hours.	Tetradecanoylphorbol Acetate	50-53	C-X3-C motif chemokine ligand 1	Homo sapiens	97-108
12631113-11	2003	Incubation of MCs with phorbol myristate acetate (PMA) for four hours resulted in an increase in fractalkine mRNA expression that could be suppressed by calphostin C or depletion of PKC by pretreatment with PMA for 24 hours.	Tetradecanoylphorbol Acetate	207-210	C-X3-C motif chemokine ligand 1	Homo sapiens	97-108
12631114-21	2003	The phorbol ester, PMA (phorbol 12-myristate 13-acetate), a PKC activator, mimicked the effect of PTH on chondrocyte differentiation.	Tetradecanoylphorbol Acetate	19-22	protein kinase C alpha	Homo sapiens	60-63
12631114-21	2003	The phorbol ester, PMA (phorbol 12-myristate 13-acetate), a PKC activator, mimicked the effect of PTH on chondrocyte differentiation.	Tetradecanoylphorbol Acetate	24-55	protein kinase C alpha	Homo sapiens	60-63
12566242-5	2003	TPA or TNFalpha induces also the binding of nuclear proteins (extracted from treated CTB) to a radiolabelled oligonucleotide corresponding to the consensus sequence of the TPA responsive element.	Tetradecanoylphorbol Acetate	172-175	tumor necrosis factor	Homo sapiens	7-15
12519122-5	2003	In neural crest cells, TPA was found to be necessary for both microphthalmia associated transcription factor (Mitf) up-regulation and for melanin synthesis.	Tetradecanoylphorbol Acetate	23-26	melanogenesis associated transcription factor	Mus musculus	110-114
12519122-6	2003	Using northern blots, we show that in DMEL-2 cells, TPA significantly increases the messenger ribonucleic acid (mRNA) levels of the tyrosinase gene family (tyrosinase, Tyrp1 and Dct) and the expression of Mitf.	Tetradecanoylphorbol Acetate	52-55	melanogenesis associated transcription factor	Mus musculus	205-209
12409308-4	2003	This study investigated the effect of salicylic acid on phorbol 12-myristate 13-acetate (PMA)- and TNFalpha-induced insulin resistance in a human embryonic kidney 293 (HEK293) cell line stably expressing recombinant human IRS1.	Tetradecanoylphorbol Acetate	56-87	insulin	Homo sapiens	116-123
12433930-3	2003	The purpose of this work was to explore the molecular mechanisms involved in the TPA regulation of ubiquitous 5-aminolevulinate synthase (ALAS) gene expression, the first and rate-controlling step of the heme biosynthesis.	Tetradecanoylphorbol Acetate	81-84	5'-aminolevulinate synthase 1	Homo sapiens	110-136
12433930-3	2003	The purpose of this work was to explore the molecular mechanisms involved in the TPA regulation of ubiquitous 5-aminolevulinate synthase (ALAS) gene expression, the first and rate-controlling step of the heme biosynthesis.	Tetradecanoylphorbol Acetate	81-84	5'-aminolevulinate synthase 1	Homo sapiens	138-142
12433930-7	2003	Sequence and deletion analysis detected a TPA response element (TRE), located between -261 and -255 (TRE-ALAS), that was critical for TPA regulation.	Tetradecanoylphorbol Acetate	42-45	5'-aminolevulinate synthase 1	Homo sapiens	105-109
12433930-7	2003	Sequence and deletion analysis detected a TPA response element (TRE), located between -261 and -255 (TRE-ALAS), that was critical for TPA regulation.	Tetradecanoylphorbol Acetate	134-137	5'-aminolevulinate synthase 1	Homo sapiens	105-109
12433930-8	2003	We demonstrated that c-Fos, c-Jun, and JunD are involved in TPA inhibitory effect due to their ability to bind TRE-ALAS, evidenced by supershift analysis and their capacity to repress promoter activity in transfection assays.	Tetradecanoylphorbol Acetate	60-63	5'-aminolevulinate synthase 1	Homo sapiens	115-119
12433930-9	2003	Repression of ALAS promoter activity by TPA treatment or Fos/Jun overexpression was largely relieved when CRE protein-binding protein or p300 was ectopically expressed.	Tetradecanoylphorbol Acetate	40-43	5'-aminolevulinate synthase 1	Homo sapiens	14-18
12433930-11	2003	We propose that the decrease in ALAS basal activity observed in the presence of TPA may reflect a lower ability of this promoter to assemble the productive pre-initiation complex due to CRE protein-binding protein sequestration.	Tetradecanoylphorbol Acetate	80-83	5'-aminolevulinate synthase 1	Homo sapiens	32-36
12433932-5	2003	These COX-2 inhibitors could also inhibit 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation.	Tetradecanoylphorbol Acetate	42-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	6-11
12614568-9	2003	Using either the MDR1 or the GFP gene we could demonstrate enhanced expression when cells were pretreated with phorbol 12-myristate 13-acetate (PMA) at low concentrations.	Tetradecanoylphorbol Acetate	111-142	ATP binding cassette subfamily B member 1	Homo sapiens	17-21
12614568-9	2003	Using either the MDR1 or the GFP gene we could demonstrate enhanced expression when cells were pretreated with phorbol 12-myristate 13-acetate (PMA) at low concentrations.	Tetradecanoylphorbol Acetate	144-147	ATP binding cassette subfamily B member 1	Homo sapiens	17-21
12504804-3	2003	Overnight culture with 100 ng/mL pertussis toxin (PTX) or 10nM PMA significantly reduced the combined insulinotropic action (P&lt;0.05 and P&lt;0.001, respectively) and the sole stimulatory effects of GLP-1 (PTX treatment; P&lt;0.01) or ACh (PMA treatment; P&lt;0.05).	Tetradecanoylphorbol Acetate	63-66	glucagon	Homo sapiens	201-206
12409308-0	2003	Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.	Tetradecanoylphorbol Acetate	24-55	insulin	Homo sapiens	114-121
12475762-7	2003	The combined application of the Ca(2+) ionophore ionomycin (1 microg/ml) and the phorbol ester phorbol 12-myristate 13-acetate (PMA; 5 microg/ml) stimulated IFN-gamma production, an effect again reversed by hyperosmolarity.	Tetradecanoylphorbol Acetate	95-126	interferon gamma	Homo sapiens	157-166
12388064-0	2003	Elevated L-PGDS activity contributes to PMA-induced apoptosis concomitant with downregulation of PI3-K.	Tetradecanoylphorbol Acetate	40-43	prostaglandin D2 synthase	Homo sapiens	9-15
12388064-2	2003	Because protein kinase C (PKC) has been shown to be involved in the apoptotic process of various cell types, we examined the potential role of L-PGDS in phorbol 12-myristate 13-acetate (PMA)-induced apoptosis.	Tetradecanoylphorbol Acetate	186-189	prostaglandin D2 synthase	Homo sapiens	143-149
12388064-4	2003	Treatment of cells with PMA or L-PGDS decreased phosphatidylinositol 3-kinase (PI3-K) activity and concomitantly inhibited protein kinase B (PKB/Akt) phosphorylation, which led to the hypophosphorylation and activation of Bad.	Tetradecanoylphorbol Acetate	24-27	AKT serine/threonine kinase 1	Homo sapiens	141-148
12475762-7	2003	The combined application of the Ca(2+) ionophore ionomycin (1 microg/ml) and the phorbol ester phorbol 12-myristate 13-acetate (PMA; 5 microg/ml) stimulated IFN-gamma production, an effect again reversed by hyperosmolarity.	Tetradecanoylphorbol Acetate	128-131	interferon gamma	Homo sapiens	157-166
12504823-8	2003	Treatment of adeno-PKC-betaII infected cardiomyocytes with phorbol 12-myristate 13-acetate (PMA) resulted in an 8-fold increase of ACE mRNA expression, whereas ACE mRNA levels only increased around 2-fold in uninfected or adeno-GFP (green fluorescent protein) infected cardiomyocytes with similar PMA treatment.	Tetradecanoylphorbol Acetate	59-90	angiotensin I converting enzyme	Rattus norvegicus	131-134
12507899-7	2003	Addition of various cytokines (interferon-gamma, tumor necrosis factor-alpha) or a phorbol ester [12-O-tetradecanoylphorbol-13-acetate (TPA)] only induced p16, but not p14(ARF).	Tetradecanoylphorbol Acetate	98-134	cyclin dependent kinase inhibitor 2A	Homo sapiens	155-158
12507899-7	2003	Addition of various cytokines (interferon-gamma, tumor necrosis factor-alpha) or a phorbol ester [12-O-tetradecanoylphorbol-13-acetate (TPA)] only induced p16, but not p14(ARF).	Tetradecanoylphorbol Acetate	136-139	cyclin dependent kinase inhibitor 2A	Homo sapiens	155-158
12507899-9	2003	Addition of MAPK inhibitor blocked cytokine and TPA-induced p16 expression.	Tetradecanoylphorbol Acetate	48-51	cyclin dependent kinase inhibitor 2A	Homo sapiens	60-63
14680506-9	2003	Interestingly, macrophages stimulated with phorbol 12-myristate 13-acetate/ionomycin displayed an augmented IL-10 response upon addition of dibutyryl cAMP, with corresponding downregulation in TNF-alpha, suggesting a complex interaction between protein kinase C and protein kinase A in cytokine regulation.	Tetradecanoylphorbol Acetate	43-74	tumor necrosis factor	Homo sapiens	193-202
12602901-9	2003	The GHRH antagonist JV-1-38 suppressed the T47D cell growth in vitro stimulated by PKC activator (phorbol-12-myristate-13-acetate).	Tetradecanoylphorbol Acetate	98-129	growth hormone releasing hormone	Homo sapiens	4-8
12504823-8	2003	Treatment of adeno-PKC-betaII infected cardiomyocytes with phorbol 12-myristate 13-acetate (PMA) resulted in an 8-fold increase of ACE mRNA expression, whereas ACE mRNA levels only increased around 2-fold in uninfected or adeno-GFP (green fluorescent protein) infected cardiomyocytes with similar PMA treatment.	Tetradecanoylphorbol Acetate	92-95	angiotensin I converting enzyme	Rattus norvegicus	131-134
12401518-4	2003	In contrast to the Akt stimulation caused by PKC inhibitors, PMA attenuated Akt/PKB phosphorylation.	Tetradecanoylphorbol Acetate	61-64	AKT serine/threonine kinase 1	Homo sapiens	76-79
12708472-5	2003	Among all neuroblastoma cells, expression of NF-M and CGA was stable at a high level throughout TPA-induced differentiation.	Tetradecanoylphorbol Acetate	96-99	chromogranin A	Homo sapiens	54-57
12401518-4	2003	In contrast to the Akt stimulation caused by PKC inhibitors, PMA attenuated Akt/PKB phosphorylation.	Tetradecanoylphorbol Acetate	61-64	AKT serine/threonine kinase 1	Homo sapiens	80-83
12558797-4	2003	Microinjection of an anti-Grb2/Ash antibody, but not control IgG, inhibited the insulin-induced actin reorganization, whereas the TPA- and 8-bromo-cAMP-induced morphological changes were not inhibited by microinjection of the anti-Grb2/Ash antibody.	Tetradecanoylphorbol Acetate	130-133	growth factor receptor bound protein 2	Homo sapiens	31-34
14995067-4	2003	Phorbol 12-myristate 13-acetate (PMA) treatment led to an increase in c-mpl promoter activity.	Tetradecanoylphorbol Acetate	0-31	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	70-75
14995067-4	2003	Phorbol 12-myristate 13-acetate (PMA) treatment led to an increase in c-mpl promoter activity.	Tetradecanoylphorbol Acetate	33-36	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	70-75
14677764-2	2003	Little is known about molecular mechanisms of constitutive expression of CD40L on some non-Hodgkin"s lymphomas, especially about involvement of two signal pathways regulating its expression in normal cells; one involving calcineurin, and the other protein kinase C. We analyzed by flow cytometry the effects of 6-hour stimulation of both pathways (stimuli: PMA and ionomycin) and their inhibitors: cyclosporin A and chelerythrine, on CD40L expression.	Tetradecanoylphorbol Acetate	357-360	CD40 ligand	Homo sapiens	73-78
12813560-9	2003	We used the PKC activator TPA (12-O-tetradecanoyl phorbol 13-acetate) and the PKC inhibitor Calphostin C (Cal C).	Tetradecanoylphorbol Acetate	26-29	protein kinase C alpha	Homo sapiens	12-15
12813560-13	2003	We speculated that the reason for changes after TPA treatment was the interactions with activated PKC alpha, which provoked syndecan-4/PKC alpha complex translocation to integrins.	Tetradecanoylphorbol Acetate	48-51	protein kinase C alpha	Homo sapiens	98-107
12813560-13	2003	We speculated that the reason for changes after TPA treatment was the interactions with activated PKC alpha, which provoked syndecan-4/PKC alpha complex translocation to integrins.	Tetradecanoylphorbol Acetate	48-51	protein kinase C alpha	Homo sapiens	135-144
12665395-3	2003	The only widely approved recanalisation strategy is the use of intravenous alteplase (recombinant tissue-type plasminogen activator; tPA) within 3 hours of stroke onset.	Tetradecanoylphorbol Acetate	133-136	plasminogen activator, tissue type	Homo sapiens	98-131
12952351-5	2003	Lack of CD40L expression on the lymphocyte surface after stimulation with ionomycin and PMA.	Tetradecanoylphorbol Acetate	88-91	CD40 ligand	Homo sapiens	8-13
14677764-4	2003	Our experiments showed that high level of CD40L expression on the surface of 217.7 cells was reduced after stimulation with PMA.	Tetradecanoylphorbol Acetate	124-127	CD40 ligand	Homo sapiens	42-47
12496173-3	2003	The present study evaluated the potential for phorbol myristate acetate-differentiated THP-1 cells to mimic this response of primary macrophages.	Tetradecanoylphorbol Acetate	46-71	GLI family zinc finger 2	Homo sapiens	87-92
12499080-2	2003	MEM significantly inhibited PMA-induced secretions of IL-8 and MCP-1 proteins in a dose-dependent manner.	Tetradecanoylphorbol Acetate	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
12499080-4	2003	In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes.	Tetradecanoylphorbol Acetate	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
12499080-4	2003	In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes.	Tetradecanoylphorbol Acetate	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
12655482-14	2003	Activation of platelets ex vivo by addition of 10 ng/mL phorbol myristate acetate resulted in a large increase in expression of P-selectin but only slight increases in platelet aggregates and microparticles.	Tetradecanoylphorbol Acetate	56-81	selectin P	Canis lupus familiaris	128-138
12525252-2	2003	In the present study we investigated the effect of epidermal growth factor (EGF), transforming growth factor alpha (TGFalpha) and phorbol myristate acetate (PMA) on chicken ovalbumin upstream promoter-transcription factor (COUP-TF) expression in human breast cancer cells.	Tetradecanoylphorbol Acetate	130-155	nuclear receptor subfamily 2 group F member 1	Homo sapiens	223-230
12496432-5	2003	The gammadelta T cells in the lungs of BCG-infected mice secreted IFN-gamma following in vitro stimulation with ionomycin and PMA and were cytotoxic against BCG-infected peritoneal macrophages as well as against the uninfected J774 macrophage cell line.	Tetradecanoylphorbol Acetate	126-129	interferon gamma	Mus musculus	66-75
12477864-14	2003	A chromatin immunoprecipitation assay showed that all three proteins associated specifically with RAP promoter DNA in vivo and that, when C/EBPalpha was removed from a tetradecanoyl phorbol acetate-treated JSC-1 primary effusion lymphoma cell lysate, the levels of association of RTA and RAP with the RAP promoter were reduced 3- and 13-fold, respectively.	Tetradecanoylphorbol Acetate	168-197	CCAAT enhancer binding protein alpha	Homo sapiens	138-148
12526092-6	2002	Moreover, phosphorylation of deoxyhypusine synthase in intact CHO cells was revealed and the expression of phosphorylated deoxyhypusine synthase was significantly diminished by diacyl ethylene glycol (DAEG), a PKC inhibitor, and enhanced by phorbol 12-myristate 13-acetate (PMA) or Ca(2+)/DAG.	Tetradecanoylphorbol Acetate	274-277	deoxyhypusine synthase	Cricetulus griseus	29-51
12526092-6	2002	Moreover, phosphorylation of deoxyhypusine synthase in intact CHO cells was revealed and the expression of phosphorylated deoxyhypusine synthase was significantly diminished by diacyl ethylene glycol (DAEG), a PKC inhibitor, and enhanced by phorbol 12-myristate 13-acetate (PMA) or Ca(2+)/DAG.	Tetradecanoylphorbol Acetate	241-272	deoxyhypusine synthase	Cricetulus griseus	29-51
12526092-6	2002	Moreover, phosphorylation of deoxyhypusine synthase in intact CHO cells was revealed and the expression of phosphorylated deoxyhypusine synthase was significantly diminished by diacyl ethylene glycol (DAEG), a PKC inhibitor, and enhanced by phorbol 12-myristate 13-acetate (PMA) or Ca(2+)/DAG.	Tetradecanoylphorbol Acetate	241-272	deoxyhypusine synthase	Cricetulus griseus	122-144
12526092-6	2002	Moreover, phosphorylation of deoxyhypusine synthase in intact CHO cells was revealed and the expression of phosphorylated deoxyhypusine synthase was significantly diminished by diacyl ethylene glycol (DAEG), a PKC inhibitor, and enhanced by phorbol 12-myristate 13-acetate (PMA) or Ca(2+)/DAG.	Tetradecanoylphorbol Acetate	274-277	deoxyhypusine synthase	Cricetulus griseus	122-144
12526092-7	2002	Endogenous PKC in CHO cell and cell lysate was able to phosphorylate deoxyhypusine synthase and this modification is enhanced by PMA or Ca(2+) plus DAG.	Tetradecanoylphorbol Acetate	129-132	deoxyhypusine synthase	Cricetulus griseus	69-91
12376550-6	2002	In addition, phorbol myristate acetate stimulation of the NADPH oxidase caused apoptosis, as evidenced by apoptosis-specific phosphatidylserine externalization, increased caspase-3 activity, chromatin condensation, and nuclear fragmentation.	Tetradecanoylphorbol Acetate	13-38	caspase 3	Homo sapiens	171-180
12468040-2	2002	SH-SY5Y cells express the intracellular factors activated through the receptors of the TGFbeta superfamily members, Smad1 and Smad4, as in basal conditions or after differentiation with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or retinoic acid (RA).	Tetradecanoylphorbol Acetate	186-223	transforming growth factor beta 1	Homo sapiens	87-94
12468040-2	2002	SH-SY5Y cells express the intracellular factors activated through the receptors of the TGFbeta superfamily members, Smad1 and Smad4, as in basal conditions or after differentiation with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or retinoic acid (RA).	Tetradecanoylphorbol Acetate	225-228	transforming growth factor beta 1	Homo sapiens	87-94
12468040-3	2002	TGF-beta1 and BMP-2 induce differentiation in SH-SY5Y cells by different pathways: the effect of TGF-beta1 is potentiated by TPA and the effect of BMP-2 is blocked by RA.	Tetradecanoylphorbol Acetate	125-128	transforming growth factor beta 1	Homo sapiens	0-9
12468040-3	2002	TGF-beta1 and BMP-2 induce differentiation in SH-SY5Y cells by different pathways: the effect of TGF-beta1 is potentiated by TPA and the effect of BMP-2 is blocked by RA.	Tetradecanoylphorbol Acetate	125-128	transforming growth factor beta 1	Homo sapiens	97-106
12468040-4	2002	Cell differentiation due to TGF-beta1 treatment is accompanied by an increase in tyrosine hydroxylase (TH) expression, more pronounced in the presence of TPA or RA and counteracted by BMP-2.	Tetradecanoylphorbol Acetate	154-157	transforming growth factor beta 1	Homo sapiens	28-37
12468040-4	2002	Cell differentiation due to TGF-beta1 treatment is accompanied by an increase in tyrosine hydroxylase (TH) expression, more pronounced in the presence of TPA or RA and counteracted by BMP-2.	Tetradecanoylphorbol Acetate	154-157	tyrosine hydroxylase	Homo sapiens	81-101
12183077-3	2002	We found that the specific PKC inhibitor GF109203 suppressed the morphological change and the alpha-naphthyl acetate esterase activity induced in ML-1 cells by treatment with KH1060 plus TPA.	Tetradecanoylphorbol Acetate	187-190	protein kinase C alpha	Homo sapiens	27-30
12445825-5	2002	These results indicate that SF/HGF and TPA induce the ectodomain shedding of nectin-1alpha presumably by a metalloprotease, and have raised the possibility that this shedding is involved in the SF/HGF- and TPA-induced cell-cell dissociation.	Tetradecanoylphorbol Acetate	39-42	hepatocyte growth factor	Canis lupus familiaris	194-201
12445825-5	2002	These results indicate that SF/HGF and TPA induce the ectodomain shedding of nectin-1alpha presumably by a metalloprotease, and have raised the possibility that this shedding is involved in the SF/HGF- and TPA-induced cell-cell dissociation.	Tetradecanoylphorbol Acetate	206-209	hepatocyte growth factor	Canis lupus familiaris	28-34
12417276-2	2002	Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) treatment, and can then be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL).	Tetradecanoylphorbol Acetate	80-105	GLI family zinc finger 2	Homo sapiens	6-11
12417276-2	2002	Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) treatment, and can then be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL).	Tetradecanoylphorbol Acetate	107-110	GLI family zinc finger 2	Homo sapiens	6-11
12359724-4	2002	Efficient transfer of PrP(C) was detected with the presence of phorbol 12-myristate 13-acetate, an activator of protein kinase C. Maximum PrP(C) transfer was observed when both donor and recipient cells were activated.	Tetradecanoylphorbol Acetate	63-94	prion protein	Homo sapiens	22-28
12359724-4	2002	Efficient transfer of PrP(C) was detected with the presence of phorbol 12-myristate 13-acetate, an activator of protein kinase C. Maximum PrP(C) transfer was observed when both donor and recipient cells were activated.	Tetradecanoylphorbol Acetate	63-94	prion protein	Homo sapiens	138-144
12183077-5	2002	ML-1 cells treated with KH1060 alone increased translocation of PKC theta, whereas cells treated with TPA alone increased translocation of PKC alpha and PKC epsilon.	Tetradecanoylphorbol Acetate	102-105	protein kinase C alpha	Homo sapiens	139-148
12444974-6	2002	In addition, NAMI-A markedly reduced serum stimulated- and completely suppressed phorbol 12-myristate 13-acetate (PMA)-triggered MAPK/ERK kinase activity.	Tetradecanoylphorbol Acetate	81-112	mitogen-activated protein kinase 1	Homo sapiens	134-137
12452835-6	2002	In the A549 cells, gp-340 was up-regulated along with the PMA-induced proinflammatory expression of both IL-6 and IL-8.	Tetradecanoylphorbol Acetate	58-61	interleukin 6	Homo sapiens	105-109
12452835-6	2002	In the A549 cells, gp-340 was up-regulated along with the PMA-induced proinflammatory expression of both IL-6 and IL-8.	Tetradecanoylphorbol Acetate	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
12657248-6	2002	Furthermore, IL-2, IL-4, IL-5, and IFN-gamma secretion by Hut 78 cells or CD3(+) T cells stimulated with PMA plus ionomycin or anti-CD3 antibody plus PMA were inhibited in a concentration-dependent manner by BTPs.	Tetradecanoylphorbol Acetate	105-108	interferon gamma	Homo sapiens	35-44
12657248-6	2002	Furthermore, IL-2, IL-4, IL-5, and IFN-gamma secretion by Hut 78 cells or CD3(+) T cells stimulated with PMA plus ionomycin or anti-CD3 antibody plus PMA were inhibited in a concentration-dependent manner by BTPs.	Tetradecanoylphorbol Acetate	150-153	interleukin 2	Homo sapiens	13-17
12657248-6	2002	Furthermore, IL-2, IL-4, IL-5, and IFN-gamma secretion by Hut 78 cells or CD3(+) T cells stimulated with PMA plus ionomycin or anti-CD3 antibody plus PMA were inhibited in a concentration-dependent manner by BTPs.	Tetradecanoylphorbol Acetate	150-153	interferon gamma	Homo sapiens	35-44
12444974-6	2002	In addition, NAMI-A markedly reduced serum stimulated- and completely suppressed phorbol 12-myristate 13-acetate (PMA)-triggered MAPK/ERK kinase activity.	Tetradecanoylphorbol Acetate	114-117	mitogen-activated protein kinase 1	Homo sapiens	134-137
12444974-7	2002	NAMI-A was also able to inhibit the phosphorylation of MEK, the upstream activator of ERK, and, similar to both the protein kinase C (PKC) inhibitor GF109203X and the MAPK/ERK (MEK) inhibitor PD98059, it completely counteracted PMA-induced ERK phosphorylation.	Tetradecanoylphorbol Acetate	228-231	mitogen-activated protein kinase kinase 7	Homo sapiens	55-58
12430000-5	2002	Levels of expression of two genes, human flavoprotein subunit of complex II and JKTBP, were downregulated by TPA, and expression of two genes, human golgin p245 and bcl-xL, was upregulated.	Tetradecanoylphorbol Acetate	109-112	heterogeneous nuclear ribonucleoprotein D like	Homo sapiens	80-85
12473063-5	2002	Furthermore, in supernatants from whole blood samples stimulated with phorbol 12-myristate 13-acetate and ionomycin, production of IFN-gamma was significantly decreased, while IL-4 production remained unchanged in AD patients compared with healthy controls.	Tetradecanoylphorbol Acetate	70-101	interferon gamma	Homo sapiens	131-140
12473063-5	2002	Furthermore, in supernatants from whole blood samples stimulated with phorbol 12-myristate 13-acetate and ionomycin, production of IFN-gamma was significantly decreased, while IL-4 production remained unchanged in AD patients compared with healthy controls.	Tetradecanoylphorbol Acetate	70-101	interleukin 4	Homo sapiens	176-180
12454035-8	2002	The PKC inhibitor GF109203X inhibited PMA-induced, but not basal or EGF-induced, phosphorylation of ERK, whereas the EGF receptor inhibitor tyrphostin AG1478 blocked basal and EGF-, but not PMA-, induced phosphorylation of ERK.	Tetradecanoylphorbol Acetate	38-41	protein kinase C alpha	Homo sapiens	4-7
12454040-16	2002	TIMP-1 protein levels were increased 27% +/- 9.3% and 15% +/- 11% in the media of cells exposed for 24 hours to 100 nM LA and 100 nM PMA, respectively (n = 5).	Tetradecanoylphorbol Acetate	133-136	TIMP metallopeptidase inhibitor 1	Homo sapiens	0-6
12430000-5	2002	Levels of expression of two genes, human flavoprotein subunit of complex II and JKTBP, were downregulated by TPA, and expression of two genes, human golgin p245 and bcl-xL, was upregulated.	Tetradecanoylphorbol Acetate	109-112	BCL2 like 1	Homo sapiens	165-171
12430000-6	2002	Moreover, we found that the changes in expression of flavo-protein, JKTBP and bcl-xL induced by TPA were blocked by treatment with protein kinase C (PKC) or mitogen-activated protein (MAP) kinase inhibitors that prevent TPA-induced differentiation of TSU-Pr1 cells.	Tetradecanoylphorbol Acetate	96-99	heterogeneous nuclear ribonucleoprotein D like	Homo sapiens	68-73
12430000-6	2002	Moreover, we found that the changes in expression of flavo-protein, JKTBP and bcl-xL induced by TPA were blocked by treatment with protein kinase C (PKC) or mitogen-activated protein (MAP) kinase inhibitors that prevent TPA-induced differentiation of TSU-Pr1 cells.	Tetradecanoylphorbol Acetate	96-99	BCL2 like 1	Homo sapiens	78-84
12430000-6	2002	Moreover, we found that the changes in expression of flavo-protein, JKTBP and bcl-xL induced by TPA were blocked by treatment with protein kinase C (PKC) or mitogen-activated protein (MAP) kinase inhibitors that prevent TPA-induced differentiation of TSU-Pr1 cells.	Tetradecanoylphorbol Acetate	220-223	heterogeneous nuclear ribonucleoprotein D like	Homo sapiens	68-73
12430000-6	2002	Moreover, we found that the changes in expression of flavo-protein, JKTBP and bcl-xL induced by TPA were blocked by treatment with protein kinase C (PKC) or mitogen-activated protein (MAP) kinase inhibitors that prevent TPA-induced differentiation of TSU-Pr1 cells.	Tetradecanoylphorbol Acetate	220-223	BCL2 like 1	Homo sapiens	78-84
12454035-7	2002	Phorbol 12-myristate 13-acetate (PMA) caused PKC-alpha, -betaI, and - epsilon, initially present in the cytoplasm, to be translocated to the membrane and nuclear subcellular fractions and PKC-delta to be depleted from the cytoskeleton.	Tetradecanoylphorbol Acetate	0-31	protein kinase C alpha	Homo sapiens	45-54
12454035-7	2002	Phorbol 12-myristate 13-acetate (PMA) caused PKC-alpha, -betaI, and - epsilon, initially present in the cytoplasm, to be translocated to the membrane and nuclear subcellular fractions and PKC-delta to be depleted from the cytoskeleton.	Tetradecanoylphorbol Acetate	33-36	protein kinase C alpha	Homo sapiens	45-54
12472880-3	2002	Activation of a coexpressed alpha2A-adrenoceptor or muscarinic M4 receptor inhibited the stimulation by TPA almost completely in a pertussis toxin-sensitive manner.	Tetradecanoylphorbol Acetate	104-107	adrenergic receptor, alpha 2a	Mus musculus	28-48
12444159-8	2002	Piceatannol also inhibited NF-kappaB activated by H(2)O(2), PMA, LPS, okadaic acid, and ceramide.	Tetradecanoylphorbol Acetate	60-63	nuclear factor kappa B subunit 1	Homo sapiens	27-36
12472895-2	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced neurite outgrowth and growth cone formation, effects that were blocked by GF 109203X (a PKC inhibitor), safingolTM(a PKCalpha-selective inhibitor), but not by rottlerinTM (a PKCdelta-selective inhibitor), indicating that PKCalpha may be selectively involved in neurite outgrowth and cytoskeletal changes of filamentous actin and beta-tubulin.	Tetradecanoylphorbol Acetate	0-36	protein kinase C alpha	Homo sapiens	139-142
12472895-2	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced neurite outgrowth and growth cone formation, effects that were blocked by GF 109203X (a PKC inhibitor), safingolTM(a PKCalpha-selective inhibitor), but not by rottlerinTM (a PKCdelta-selective inhibitor), indicating that PKCalpha may be selectively involved in neurite outgrowth and cytoskeletal changes of filamentous actin and beta-tubulin.	Tetradecanoylphorbol Acetate	0-36	protein kinase C alpha	Homo sapiens	168-176
12472895-2	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced neurite outgrowth and growth cone formation, effects that were blocked by GF 109203X (a PKC inhibitor), safingolTM(a PKCalpha-selective inhibitor), but not by rottlerinTM (a PKCdelta-selective inhibitor), indicating that PKCalpha may be selectively involved in neurite outgrowth and cytoskeletal changes of filamentous actin and beta-tubulin.	Tetradecanoylphorbol Acetate	0-36	protein kinase C alpha	Homo sapiens	272-280
12472895-2	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced neurite outgrowth and growth cone formation, effects that were blocked by GF 109203X (a PKC inhibitor), safingolTM(a PKCalpha-selective inhibitor), but not by rottlerinTM (a PKCdelta-selective inhibitor), indicating that PKCalpha may be selectively involved in neurite outgrowth and cytoskeletal changes of filamentous actin and beta-tubulin.	Tetradecanoylphorbol Acetate	38-41	protein kinase C alpha	Homo sapiens	139-142
12472895-2	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced neurite outgrowth and growth cone formation, effects that were blocked by GF 109203X (a PKC inhibitor), safingolTM(a PKCalpha-selective inhibitor), but not by rottlerinTM (a PKCdelta-selective inhibitor), indicating that PKCalpha may be selectively involved in neurite outgrowth and cytoskeletal changes of filamentous actin and beta-tubulin.	Tetradecanoylphorbol Acetate	38-41	protein kinase C alpha	Homo sapiens	168-176
12472895-2	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced neurite outgrowth and growth cone formation, effects that were blocked by GF 109203X (a PKC inhibitor), safingolTM(a PKCalpha-selective inhibitor), but not by rottlerinTM (a PKCdelta-selective inhibitor), indicating that PKCalpha may be selectively involved in neurite outgrowth and cytoskeletal changes of filamentous actin and beta-tubulin.	Tetradecanoylphorbol Acetate	38-41	protein kinase C alpha	Homo sapiens	272-280
12472895-4	2002	TPA treatment induced relocalization of PKCalpha-EGFP to growth cones and cell-cell adhesion sites, PKCgamma-EGFP to the nucleus, and PKCdelta-EGFP to the membrane ruffle, respectively.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	40-48
12472895-7	2002	We also examined the involvement of the extracellular signal-regulated kinase (ERK) MAP kinase in TPA-induced neurite outgrowth.	Tetradecanoylphorbol Acetate	98-101	mitogen-activated protein kinase 1	Homo sapiens	40-77
12472895-7	2002	We also examined the involvement of the extracellular signal-regulated kinase (ERK) MAP kinase in TPA-induced neurite outgrowth.	Tetradecanoylphorbol Acetate	98-101	mitogen-activated protein kinase 1	Homo sapiens	79-82
12472895-8	2002	TPA treatment increased phosphorylated ERK MAP kinase, but not p38 MAP kinase.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	39-42
12472895-9	2002	Specific inhibition of PKCalpha with safingol blocked the phosphorylation of ERK induced by TPA.	Tetradecanoylphorbol Acetate	92-95	protein kinase C alpha	Homo sapiens	23-31
12472895-9	2002	Specific inhibition of PKCalpha with safingol blocked the phosphorylation of ERK induced by TPA.	Tetradecanoylphorbol Acetate	92-95	mitogen-activated protein kinase 1	Homo sapiens	77-80
12472895-10	2002	More importantly, both neurite outgrowth and phosphorylation of ERK by TPA were blocked by PD 098059, a specific inhibitor of MEK (MAP kinase/ERK kinase-1), but not by SB203580, a specific inhibitor of p38 MAP kinase.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase 1	Homo sapiens	64-67
12472895-10	2002	More importantly, both neurite outgrowth and phosphorylation of ERK by TPA were blocked by PD 098059, a specific inhibitor of MEK (MAP kinase/ERK kinase-1), but not by SB203580, a specific inhibitor of p38 MAP kinase.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase kinase 7	Homo sapiens	126-129
12472895-10	2002	More importantly, both neurite outgrowth and phosphorylation of ERK by TPA were blocked by PD 098059, a specific inhibitor of MEK (MAP kinase/ERK kinase-1), but not by SB203580, a specific inhibitor of p38 MAP kinase.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase kinase 7	Homo sapiens	131-154
12472895-10	2002	More importantly, both neurite outgrowth and phosphorylation of ERK by TPA were blocked by PD 098059, a specific inhibitor of MEK (MAP kinase/ERK kinase-1), but not by SB203580, a specific inhibitor of p38 MAP kinase.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase 1	Homo sapiens	202-205
12414958-7	2002	Furthermore, electrophoretic mobility shift assays demonstrated that TPA-induced activation of AP-1, NF-kappaB, and Oct-1 activities was severely diminished in BCBL1 cells expressing the K1 cytoplasmic domain.	Tetradecanoylphorbol Acetate	69-72	solute carrier family 22 member 1	Homo sapiens	116-121
12237314-4	2002	We show that a group of rocaglamides represent highly potent and specific inhibitors of tumor necrosis factor-alpha (TNFalpha) and phorbol 12-myristate 13-acetate (PMA)-induced NF-kappaB-dependent reporter gene activity in Jurkat T cells with IC(50) values in the nanomolar range.	Tetradecanoylphorbol Acetate	131-162	nuclear factor kappa B subunit 1	Homo sapiens	177-186
12913400-10	2002	In separate experiments, tPA (1.0 microg/ml) was added to PRP before the stimulation of ADP.	Tetradecanoylphorbol Acetate	25-28	proline rich protein HaeIII subfamily 1	Mus musculus	58-61
12359735-5	2002	Moreover, the NO-induced degradation is reversed by the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), and also by the physiological PKC activators platelet-derived growth factor-BB (PDGF), angiotensin II and ATP, resulting in a normalization of neutral ceramidase protein as well as activity.	Tetradecanoylphorbol Acetate	128-131	angiotensinogen	Rattus norvegicus	221-235
12244094-4	2002	Conversely, the TPA-stimulated MEK binding and kinase activity are diminished when this region is deleted or Ser(338) and Ser(339) are mutated to alanines.	Tetradecanoylphorbol Acetate	16-19	mitogen-activated protein kinase kinase 7	Homo sapiens	31-34
12237314-4	2002	We show that a group of rocaglamides represent highly potent and specific inhibitors of tumor necrosis factor-alpha (TNFalpha) and phorbol 12-myristate 13-acetate (PMA)-induced NF-kappaB-dependent reporter gene activity in Jurkat T cells with IC(50) values in the nanomolar range.	Tetradecanoylphorbol Acetate	164-167	nuclear factor kappa B subunit 1	Homo sapiens	177-186
12237314-6	2002	Rocaglamides are able to suppress the PMA-induced expression of NF-kappaB target genes and sensitize leukemic T cells to apoptosis induced by TNFalpha, cisplatin, and gamma-irradiation.	Tetradecanoylphorbol Acetate	38-41	nuclear factor kappa B subunit 1	Homo sapiens	64-73
12421966-5	2002	Both proteins inhibited CD3(+)/CD4(+) lymphocyte proliferation induced by PMA and ionomycin in an IL-2-independent manner.	Tetradecanoylphorbol Acetate	74-77	CD4 molecule	Homo sapiens	31-34
12419319-3	2002	However, the NTR3 is also present at the cell surface of the HT29 cell line from which it is released by a mechanism activated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	130-161	sortilin 1	Homo sapiens	13-17
12419319-3	2002	However, the NTR3 is also present at the cell surface of the HT29 cell line from which it is released by a mechanism activated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	163-166	sortilin 1	Homo sapiens	13-17
12401552-3	2002	Pretreatment with phorbol-12-myristate-13-acetate inhibited the rotenone-induced decrease in procaspases-9 and -3, but not that in procaspase-12.	Tetradecanoylphorbol Acetate	18-49	caspase 3	Homo sapiens	93-113
12409145-3	2002	The expression of PAI-1 mRNA that was also increased by H(2)O(2), angiotensin II, or phorbol myristate acetate, was reversed by the MAPK kinase (MEK) inhibitor PD98059 or the specific protein kinase C (PKC) inhibitor GF109203X.	Tetradecanoylphorbol Acetate	85-110	serpin family E member 1	Rattus norvegicus	18-23
12433834-2	2002	Phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, has been shown to increase ACE mRNA at the transcriptional level in human umbilical vein endothelial cells.	Tetradecanoylphorbol Acetate	0-31	angiotensin I converting enzyme	Homo sapiens	96-99
12433834-2	2002	Phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, has been shown to increase ACE mRNA at the transcriptional level in human umbilical vein endothelial cells.	Tetradecanoylphorbol Acetate	33-36	angiotensin I converting enzyme	Homo sapiens	96-99
12433834-9	2002	Electrophoretic mobility shift assays and supershift analyses have revealed that activating protein 1 (AP-1) is the transcription factor binding the cAMP-responsive element/12-O-tetradecanoylphorbol 13-acetate-responsive element located in the ACE promoter after PMA stimulation.	Tetradecanoylphorbol Acetate	173-209	angiotensin I converting enzyme	Homo sapiens	244-247
12433834-12	2002	Our results demonstrate that the two transcription factors, Egr-1 and AP-1, are involved in the PMA-induced ACE transcriptional activation in human endothelial cells via the activation of the extracellular signal-regulated kinase 1/2 signaling pathway.	Tetradecanoylphorbol Acetate	96-99	angiotensin I converting enzyme	Homo sapiens	108-111
12433834-12	2002	Our results demonstrate that the two transcription factors, Egr-1 and AP-1, are involved in the PMA-induced ACE transcriptional activation in human endothelial cells via the activation of the extracellular signal-regulated kinase 1/2 signaling pathway.	Tetradecanoylphorbol Acetate	96-99	mitogen-activated protein kinase 1	Homo sapiens	192-231
12421966-5	2002	Both proteins inhibited CD3(+)/CD4(+) lymphocyte proliferation induced by PMA and ionomycin in an IL-2-independent manner.	Tetradecanoylphorbol Acetate	74-77	interleukin 2	Homo sapiens	98-102
12372810-2	2002	The effect of the phorbol ester phorbol 12-myristate 13-acetate (PMA), an in vitro PKC agonist, on OH- gradient-driven 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS)-sensitive 36Cl uptake in Caco-2 cells was assessed.	Tetradecanoylphorbol Acetate	32-63	protein kinase C alpha	Homo sapiens	83-86
12390318-3	2002	In contrast, after stimulation with both HCV core antigen and phorbol myristate acetate (PMA) plus ionomycin (IO), the expression of CD40L on CD4 lymphocytes was significantly higher in the ribavirin group compared with controls.	Tetradecanoylphorbol Acetate	62-87	CD40 ligand	Homo sapiens	133-138
12372816-2	2002	We recently showed that the phorbol ester PMA (100 nM) induces prompt activation of the novel isoform PKCepsilon followed by late activation of the conventional isoform PKCalpha in T84 intestinal epithelia.	Tetradecanoylphorbol Acetate	42-45	protein kinase C alpha	Homo sapiens	169-177
12372816-9	2002	The Ca2+ agonist thapsigargin (5 microM) induced early activation of PKC when added simultaneously with PMA.	Tetradecanoylphorbol Acetate	104-107	protein kinase C alpha	Homo sapiens	69-72
12376314-1	2002	Culturing clonal beta-cells (HIT-T15) overnight in the presence of phorbol ester [phorbol myristate acetate (PMA)] enhanced insulin secretion while causing downregulation of some protein kinase C (PKC) isoforms and most PKC activity.	Tetradecanoylphorbol Acetate	82-107	insulin	Homo sapiens	124-131
12376314-1	2002	Culturing clonal beta-cells (HIT-T15) overnight in the presence of phorbol ester [phorbol myristate acetate (PMA)] enhanced insulin secretion while causing downregulation of some protein kinase C (PKC) isoforms and most PKC activity.	Tetradecanoylphorbol Acetate	82-107	protein kinase C alpha	Homo sapiens	197-200
12376314-1	2002	Culturing clonal beta-cells (HIT-T15) overnight in the presence of phorbol ester [phorbol myristate acetate (PMA)] enhanced insulin secretion while causing downregulation of some protein kinase C (PKC) isoforms and most PKC activity.	Tetradecanoylphorbol Acetate	82-107	protein kinase C alpha	Homo sapiens	220-223
12376314-1	2002	Culturing clonal beta-cells (HIT-T15) overnight in the presence of phorbol ester [phorbol myristate acetate (PMA)] enhanced insulin secretion while causing downregulation of some protein kinase C (PKC) isoforms and most PKC activity.	Tetradecanoylphorbol Acetate	109-112	insulin	Homo sapiens	124-131
12376314-1	2002	Culturing clonal beta-cells (HIT-T15) overnight in the presence of phorbol ester [phorbol myristate acetate (PMA)] enhanced insulin secretion while causing downregulation of some protein kinase C (PKC) isoforms and most PKC activity.	Tetradecanoylphorbol Acetate	109-112	protein kinase C alpha	Homo sapiens	197-200
12376314-1	2002	Culturing clonal beta-cells (HIT-T15) overnight in the presence of phorbol ester [phorbol myristate acetate (PMA)] enhanced insulin secretion while causing downregulation of some protein kinase C (PKC) isoforms and most PKC activity.	Tetradecanoylphorbol Acetate	109-112	protein kinase C alpha	Homo sapiens	220-223
12376314-7	2002	Therefore, stimulation of insulin secretion by PMA, and presumably by endogenous diacylglycerol, involves the activation of PKC isoforms delta and/or mu, and also PKC-alpha.	Tetradecanoylphorbol Acetate	47-50	insulin	Homo sapiens	26-33
12376314-7	2002	Therefore, stimulation of insulin secretion by PMA, and presumably by endogenous diacylglycerol, involves the activation of PKC isoforms delta and/or mu, and also PKC-alpha.	Tetradecanoylphorbol Acetate	47-50	protein kinase C alpha	Homo sapiens	163-172
12381534-8	2002	Treatment with PMA induced translocation of PKC-alpha, -delta, and -mu from cytosol to membrane.	Tetradecanoylphorbol Acetate	15-18	protein kinase C alpha	Homo sapiens	44-70
12381534-10	2002	Addition of PKC-alpha inhibitor Go-6976 at a nanomolar concentration, other PKC inhibitors Go-6983 and GF-109203X, or PKC-delta-specific inhibitor rottlerin significantly inhibited PMA-mediated NT release.	Tetradecanoylphorbol Acetate	181-184	protein kinase C alpha	Homo sapiens	12-21
12381534-10	2002	Addition of PKC-alpha inhibitor Go-6976 at a nanomolar concentration, other PKC inhibitors Go-6983 and GF-109203X, or PKC-delta-specific inhibitor rottlerin significantly inhibited PMA-mediated NT release.	Tetradecanoylphorbol Acetate	181-184	protein kinase C alpha	Homo sapiens	12-15
12482394-3	2002	The cytochrome c-sensitive TCR-expressing hybridoma (2B4) was stimulated with pigeon cytochrome c antigen, anti-CD3 crosslinking, or PMA and ionomycin, in the presence or absence of CP, and the resulting IL-2 produced was measured in a bioassay using an IL-2-dependent cell line (CTLL-2).	Tetradecanoylphorbol Acetate	133-136	cytochrome c, somatic	Homo sapiens	4-16
12390318-3	2002	In contrast, after stimulation with both HCV core antigen and phorbol myristate acetate (PMA) plus ionomycin (IO), the expression of CD40L on CD4 lymphocytes was significantly higher in the ribavirin group compared with controls.	Tetradecanoylphorbol Acetate	62-87	CD4 molecule	Homo sapiens	133-136
12390318-3	2002	In contrast, after stimulation with both HCV core antigen and phorbol myristate acetate (PMA) plus ionomycin (IO), the expression of CD40L on CD4 lymphocytes was significantly higher in the ribavirin group compared with controls.	Tetradecanoylphorbol Acetate	89-92	CD40 ligand	Homo sapiens	133-138
12390318-3	2002	In contrast, after stimulation with both HCV core antigen and phorbol myristate acetate (PMA) plus ionomycin (IO), the expression of CD40L on CD4 lymphocytes was significantly higher in the ribavirin group compared with controls.	Tetradecanoylphorbol Acetate	89-92	CD4 molecule	Homo sapiens	133-136
12429713-0	2002	Role of CD80, CD86, and CTLA4 on mouse CD4(+) T lymphocytes in enhancing cell-cycle progression and survival after activation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	131-134	CD80 antigen	Mus musculus	8-12
12445204-7	2002	The presence of keratin 16 at the transition between mitotically active and differentiating cells is recapitulated in primary keratinocytes cultured in vitro and in phorbol 12-myristate 13-acetate-treated back skin in vivo.	Tetradecanoylphorbol Acetate	165-196	keratin 16	Mus musculus	16-26
12399408-6	2002	In contrast, the protein kinase C activator, phorbol 12-myristate 13-acetate, greatly increased AVP transcription in the absence of TTX, but this effect was blocked by TTX, indicating that the phorbol 12-myristate 13-acetate acted indirectly via synaptic input.	Tetradecanoylphorbol Acetate	45-76	arginine vasopressin	Rattus norvegicus	96-99
12399408-6	2002	In contrast, the protein kinase C activator, phorbol 12-myristate 13-acetate, greatly increased AVP transcription in the absence of TTX, but this effect was blocked by TTX, indicating that the phorbol 12-myristate 13-acetate acted indirectly via synaptic input.	Tetradecanoylphorbol Acetate	193-224	arginine vasopressin	Rattus norvegicus	96-99
12510792-7	2002	In addition, Dodutang potently inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated human mast cells.	Tetradecanoylphorbol Acetate	125-156	tumor necrosis factor	Homo sapiens	58-85
12510792-7	2002	In addition, Dodutang potently inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated human mast cells.	Tetradecanoylphorbol Acetate	125-156	tumor necrosis factor	Homo sapiens	87-96
12510792-7	2002	In addition, Dodutang potently inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated human mast cells.	Tetradecanoylphorbol Acetate	125-156	interleukin 1 beta	Homo sapiens	99-121
12429713-3	2002	We show that CD80, CD86, and CTLA4 are induced on purified CD4(+) T cells after in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, and they play an essential role for proliferation and survival.	Tetradecanoylphorbol Acetate	105-136	CD80 antigen	Mus musculus	13-17
12429713-3	2002	We show that CD80, CD86, and CTLA4 are induced on purified CD4(+) T cells after in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, and they play an essential role for proliferation and survival.	Tetradecanoylphorbol Acetate	105-136	CD86 antigen	Mus musculus	19-23
12429713-3	2002	We show that CD80, CD86, and CTLA4 are induced on purified CD4(+) T cells after in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, and they play an essential role for proliferation and survival.	Tetradecanoylphorbol Acetate	138-141	CD80 antigen	Mus musculus	13-17
12429713-3	2002	We show that CD80, CD86, and CTLA4 are induced on purified CD4(+) T cells after in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, and they play an essential role for proliferation and survival.	Tetradecanoylphorbol Acetate	138-141	CD86 antigen	Mus musculus	19-23
12429713-9	2002	This study reveals a functional role for CD80, CD86, and CTLA4 on CD4(+) T lymphocytes and sheds light on the mechanisms by which these molecules enhance activation and survival with PMA and ionomycin.	Tetradecanoylphorbol Acetate	183-186	CD80 antigen	Mus musculus	41-45
12429713-9	2002	This study reveals a functional role for CD80, CD86, and CTLA4 on CD4(+) T lymphocytes and sheds light on the mechanisms by which these molecules enhance activation and survival with PMA and ionomycin.	Tetradecanoylphorbol Acetate	183-186	CD86 antigen	Mus musculus	47-51
12370305-0	2002	Cytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-associated kinase-mediated signal impair expression of p21(Cip1/Waf1) in phorbol 12-myristate-13- acetate-induced apoptotic cells.	Tetradecanoylphorbol Acetate	159-191	cyclin dependent kinase inhibitor 1A	Homo sapiens	141-144
12391145-3	2002	VEGF or phorbol 12-myristate 13-acetate treatment of the T24 bladder tumor cell line resulted in a time- and dose-dependent stimulation of SPK activity.	Tetradecanoylphorbol Acetate	8-39	PDZ binding kinase	Homo sapiens	139-142
12467977-3	2002	In the presence of AGC10 the cytoplasmic levels of IL-2 protein of CD4(+) and CD8(+) blood lymphocytes stimulated with phorbol myristate acetate (PMA) plus ionomycin were markedly reduced.	Tetradecanoylphorbol Acetate	119-144	interleukin 2	Homo sapiens	51-55
12467977-3	2002	In the presence of AGC10 the cytoplasmic levels of IL-2 protein of CD4(+) and CD8(+) blood lymphocytes stimulated with phorbol myristate acetate (PMA) plus ionomycin were markedly reduced.	Tetradecanoylphorbol Acetate	119-144	CD4 molecule	Homo sapiens	67-70
12467977-3	2002	In the presence of AGC10 the cytoplasmic levels of IL-2 protein of CD4(+) and CD8(+) blood lymphocytes stimulated with phorbol myristate acetate (PMA) plus ionomycin were markedly reduced.	Tetradecanoylphorbol Acetate	146-149	interleukin 2	Homo sapiens	51-55
12467977-3	2002	In the presence of AGC10 the cytoplasmic levels of IL-2 protein of CD4(+) and CD8(+) blood lymphocytes stimulated with phorbol myristate acetate (PMA) plus ionomycin were markedly reduced.	Tetradecanoylphorbol Acetate	146-149	CD4 molecule	Homo sapiens	67-70
12558054-8	2002	Incubation with A23187 in association with PMA produced the same increase in arachidonate as the VEGF treatment.	Tetradecanoylphorbol Acetate	43-46	vascular endothelial growth factor A	Homo sapiens	97-101
12397211-7	2002	The protein kinase C activator, 12-O-tetradecanoyl phorbol 13-acetate (TPA, 160 nmol/l), and prostaglandin E(2) (PGE(2), 1 micromol/l) increased FLRG mRNA accumulation up to 3-8 fold over the control level after 24 h of treatment, and these stimulatory effects were dose-dependent.	Tetradecanoylphorbol Acetate	32-69	follistatin like 3	Homo sapiens	145-149
12384259-10	2002	Phorbol 12-myristate 13-acetate, a PKC activator, inhibited the activity of both wild type and Y403H EAAT2.	Tetradecanoylphorbol Acetate	0-31	solute carrier family 1 member 2	Rattus norvegicus	101-106
12370305-0	2002	Cytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-associated kinase-mediated signal impair expression of p21(Cip1/Waf1) in phorbol 12-myristate-13- acetate-induced apoptotic cells.	Tetradecanoylphorbol Acetate	159-191	cyclin dependent kinase inhibitor 1A	Homo sapiens	145-149
12370305-0	2002	Cytosolic retention of phosphorylated extracellular signal-regulated kinase and a Rho-associated kinase-mediated signal impair expression of p21(Cip1/Waf1) in phorbol 12-myristate-13- acetate-induced apoptotic cells.	Tetradecanoylphorbol Acetate	159-191	cyclin dependent kinase inhibitor 1A	Homo sapiens	150-154
12370305-2	2002	Expression of the cell cycle inhibitor p21(Cip1/Waf1) was induced after PMA treatment in the adherent cells but not in the proapoptotic cells.	Tetradecanoylphorbol Acetate	72-75	cyclin dependent kinase inhibitor 1A	Homo sapiens	39-42
12370305-2	2002	Expression of the cell cycle inhibitor p21(Cip1/Waf1) was induced after PMA treatment in the adherent cells but not in the proapoptotic cells.	Tetradecanoylphorbol Acetate	72-75	cyclin dependent kinase inhibitor 1A	Homo sapiens	43-47
12370305-2	2002	Expression of the cell cycle inhibitor p21(Cip1/Waf1) was induced after PMA treatment in the adherent cells but not in the proapoptotic cells.	Tetradecanoylphorbol Acetate	72-75	cyclin dependent kinase inhibitor 1A	Homo sapiens	48-52
12370305-5	2002	Although ERK was phosphorylated to comparable levels in PMA-induced proapoptotic and adherent cells, nuclear distribution of phospho-ERK was seen only in the adherent, not in the proapoptotic cells.	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase 1	Homo sapiens	9-12
12441078-6	2002	Time course experiments showed that CD4 down-modulation by CADA differs in mechanism from the effects of aurintricarboxylic acid, which binds directly to CD4, and phorbol myristate acetate, which activates protein kinase C. Further analysis of CD4 mRNA levels suggested that CADA was not involved in the regulation of CD4 expression at a transcriptional level, but very likely at (post) translational levels.	Tetradecanoylphorbol Acetate	163-188	CD4 molecule	Homo sapiens	36-39
12177049-2	2002	We show that cellular PI-9 mRNA and protein are induced by IL-1beta, lipopolysaccharide, and 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	93-129	serpin family B member 9	Homo sapiens	22-26
12372337-2	2002	We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer.	Tetradecanoylphorbol Acetate	98-129	interferon gamma	Homo sapiens	172-188
12372337-2	2002	We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer.	Tetradecanoylphorbol Acetate	98-129	interferon gamma	Homo sapiens	190-199
12372337-2	2002	We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer.	Tetradecanoylphorbol Acetate	98-129	interferon gamma	Homo sapiens	231-240
12372337-2	2002	We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer.	Tetradecanoylphorbol Acetate	131-134	interferon gamma	Homo sapiens	172-188
12372337-2	2002	We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer.	Tetradecanoylphorbol Acetate	131-134	interferon gamma	Homo sapiens	190-199
12372337-2	2002	We found that treatment of polarized TBA B4-3 cells with a strong protein kinase C (PKC) agonist, phorbol 12-myristate-13-acetate (PMA), induced 3-4 days later a transient interferon-gamma (IFN-gamma) mRNA expression and vectorial IFN-gamma protein secretion toward the apical side of the monolayer.	Tetradecanoylphorbol Acetate	131-134	interferon gamma	Homo sapiens	231-240
12149272-2	2002	Previous studies demonstrated an inhibition of LPL activity and synthesis following depletion of protein kinase C (PKC) isoforms with long term treatment of 3T3-F442A adipocytes with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	183-219	protein kinase C alpha	Homo sapiens	115-118
12376465-0	2002	Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by TPA and ATRA in gastric cancer cells.	Tetradecanoylphorbol Acetate	75-78	nuclear receptor subfamily 4 group A member 1	Homo sapiens	14-19
12370102-7	2002	Pretreatment of the cells expressing the wild type with PMA inhibited I-BOP induced Ca2+ release, however, pretreatment of the cells expressing the S331A mutant receptor with PMA did not abolish I-BOP induced Ca2+ release.	Tetradecanoylphorbol Acetate	56-59	BOP	Homo sapiens	72-75
12369848-8	2002	Inhibition of PKC with either calphostin C, a blocker of the PMA binding site, or chelerythrine chloride, an inhibitor of the active site, diminished the level of formation of PS-exposing cells.	Tetradecanoylphorbol Acetate	61-64	proline rich transmembrane protein 2	Homo sapiens	14-17
12376465-5	2002	The tetradecanoylphorbol-1,3-acetate (TPA) treatment not only resulted in up-regulation of the Nur77 mRNA level, but also led to translocation of Nur77 protein from the nucleus to the mitochondria, and caused the release of cytochrome c.	Tetradecanoylphorbol Acetate	38-41	nuclear receptor subfamily 4 group A member 1	Homo sapiens	95-100
12376465-5	2002	The tetradecanoylphorbol-1,3-acetate (TPA) treatment not only resulted in up-regulation of the Nur77 mRNA level, but also led to translocation of Nur77 protein from the nucleus to the mitochondria, and caused the release of cytochrome c.	Tetradecanoylphorbol Acetate	38-41	nuclear receptor subfamily 4 group A member 1	Homo sapiens	146-151
12376465-5	2002	The tetradecanoylphorbol-1,3-acetate (TPA) treatment not only resulted in up-regulation of the Nur77 mRNA level, but also led to translocation of Nur77 protein from the nucleus to the mitochondria, and caused the release of cytochrome c.	Tetradecanoylphorbol Acetate	38-41	cytochrome c, somatic	Homo sapiens	224-236
12376465-6	2002	This TPA-induced translocation of Nur77 was in association with the initiation of apoptosis in gastric cancer cells.	Tetradecanoylphorbol Acetate	5-8	nuclear receptor subfamily 4 group A member 1	Homo sapiens	34-39
12376465-9	2002	Furthermore, the action of Nur77 in TPA-induced apoptosis was mediated through a protein kinase C signaling pathway, while mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways were responsible for the regulation of Nur77 mRNA expression.	Tetradecanoylphorbol Acetate	36-39	nuclear receptor subfamily 4 group A member 1	Homo sapiens	27-32
12376465-10	2002	Taken together, the data revealed the dual functioning mechanisms of Nur77 in gastric cancer cells in response to TPA and ATRA.	Tetradecanoylphorbol Acetate	114-117	nuclear receptor subfamily 4 group A member 1	Homo sapiens	69-74
12396248-3	2002	To determine whether an activation of PKC would regulate the mRNA expression or the function of ENaC, we stimulated rat alveolar type II epithelial cells with phorbol 12-myristate 13-acetate (PMA), a potent PKC activator, at a concentration of 100 nM.	Tetradecanoylphorbol Acetate	159-190	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	96-100
12396248-3	2002	To determine whether an activation of PKC would regulate the mRNA expression or the function of ENaC, we stimulated rat alveolar type II epithelial cells with phorbol 12-myristate 13-acetate (PMA), a potent PKC activator, at a concentration of 100 nM.	Tetradecanoylphorbol Acetate	192-195	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	96-100
12396248-8	2002	GF 109203X, a wide-range PKC inhibitor, blocked the inhibitory effect of PMA on all ENaC subunits mRNA expression.	Tetradecanoylphorbol Acetate	73-76	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	84-88
12683216-0	2002	Modulation of interleukin-8 receptor expression by lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) in human peripheral monocytes--a preliminary study.	Tetradecanoylphorbol Acetate	80-105	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
12683216-0	2002	Modulation of interleukin-8 receptor expression by lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) in human peripheral monocytes--a preliminary study.	Tetradecanoylphorbol Acetate	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	14-27
12683216-3	2002	We found that two very known modulators, lipopolysaccharide (LPS) in presence of homologous serum and Phorbol myristate acetate (PMA) resulted in induction of IL-8 receptor by 100-120% and 75-125% respectively within 1 h in monocytes.	Tetradecanoylphorbol Acetate	102-127	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
12683216-3	2002	We found that two very known modulators, lipopolysaccharide (LPS) in presence of homologous serum and Phorbol myristate acetate (PMA) resulted in induction of IL-8 receptor by 100-120% and 75-125% respectively within 1 h in monocytes.	Tetradecanoylphorbol Acetate	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
12683216-4	2002	Based on the inhibitory effect of cycloheximide, actinomycin-D we may suggest that PMA and LPS could upregulate IL-8 receptor in monocytes through denovo protein synthesis.	Tetradecanoylphorbol Acetate	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
12270146-2	2002	We examined TPA-induced activation of the MEK1-ERK1/2 pathway in the 100,000g Triton X-insoluble fraction of CMK cells as the membrane skeleton and researched the relation of the MEK1-ERK1/2 activation with integrin expression.	Tetradecanoylphorbol Acetate	12-15	mitogen-activated protein kinase 3	Homo sapiens	47-53
12423237-8	2002	In agreement with the sensitivity of PMA-induced responses to PKC down-regulation, prolonged treatment with PMA resulted in down-regulation of PKCalpha and epsilon in these cells.	Tetradecanoylphorbol Acetate	37-40	protein kinase C, alpha	Mus musculus	143-151
12423237-8	2002	In agreement with the sensitivity of PMA-induced responses to PKC down-regulation, prolonged treatment with PMA resulted in down-regulation of PKCalpha and epsilon in these cells.	Tetradecanoylphorbol Acetate	108-111	protein kinase C, alpha	Mus musculus	143-151
12423237-9	2002	Furthermore, PMA but not ATP stimulated rapid translocation of PKCalpha from cytosol to membranes.	Tetradecanoylphorbol Acetate	13-16	protein kinase C, alpha	Mus musculus	63-71
12270146-2	2002	We examined TPA-induced activation of the MEK1-ERK1/2 pathway in the 100,000g Triton X-insoluble fraction of CMK cells as the membrane skeleton and researched the relation of the MEK1-ERK1/2 activation with integrin expression.	Tetradecanoylphorbol Acetate	12-15	mitogen-activated protein kinase 3	Homo sapiens	184-190
12226757-4	2002	In addition, ERK becomes refractory to stimulation by a subset of agonists including serum, LPA, and EGF, but remains partially responsive to the phorbol ester, TPA.	Tetradecanoylphorbol Acetate	161-164	mitogen-activated protein kinase 1	Homo sapiens	13-16
12388770-9	2002	Antigen or phorbol 12-myristate 13-acetate stimulation increased both PLD1 and PLD2 activity when expressed individually in RBL-2H3 cells.	Tetradecanoylphorbol Acetate	11-42	phospholipase D1	Rattus norvegicus	70-74
12270146-5	2002	Sustained activation of the MEK1-ERK1/2 pathway is generated in the membrane skeleton by continuous cell adhesion and seems to be essential to TPA-induced megakaryocytic differentiation of CMK cells.	Tetradecanoylphorbol Acetate	143-146	mitogen-activated protein kinase 3	Homo sapiens	33-39
12186945-5	2002	Growth-arresting signals are triggered either by transient and sustained JNK activation (by TPA and anisomycin, respectively) or by preventing both ERK and JNK activation (UO126) and are maintained, rather than induced, by p38.	Tetradecanoylphorbol Acetate	92-95	mitogen-activated protein kinase 8	Homo sapiens	73-76
12186945-1	2002	We have previously suggested that PKCalpha has a role in 12-O-Tetradecanoylphorbol-13-acetate (TPA)-mediated growth arrest and myogenic differentiation in human embryonal rhabdomyosarcoma cells (RD).	Tetradecanoylphorbol Acetate	57-93	protein kinase C alpha	Homo sapiens	34-42
12077118-0	2002	Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.	Tetradecanoylphorbol Acetate	0-31	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	66-70
12186945-1	2002	We have previously suggested that PKCalpha has a role in 12-O-Tetradecanoylphorbol-13-acetate (TPA)-mediated growth arrest and myogenic differentiation in human embryonal rhabdomyosarcoma cells (RD).	Tetradecanoylphorbol Acetate	95-98	protein kinase C alpha	Homo sapiens	34-42
12186945-2	2002	Here, by monitoring the signalling pathways triggered by TPA, we demonstrate that PKCalpha mediates these effects by inducing transient activation of c-Jun N-terminal protein kinases (JNKs) and sustained activation of both p38 kinase and extracellular signal-regulated kinases (ERKs) (all referred to as MAPKs).	Tetradecanoylphorbol Acetate	57-60	protein kinase C alpha	Homo sapiens	82-90
12186945-2	2002	Here, by monitoring the signalling pathways triggered by TPA, we demonstrate that PKCalpha mediates these effects by inducing transient activation of c-Jun N-terminal protein kinases (JNKs) and sustained activation of both p38 kinase and extracellular signal-regulated kinases (ERKs) (all referred to as MAPKs).	Tetradecanoylphorbol Acetate	57-60	mitogen-activated protein kinase 1	Homo sapiens	223-226
12186945-2	2002	Here, by monitoring the signalling pathways triggered by TPA, we demonstrate that PKCalpha mediates these effects by inducing transient activation of c-Jun N-terminal protein kinases (JNKs) and sustained activation of both p38 kinase and extracellular signal-regulated kinases (ERKs) (all referred to as MAPKs).	Tetradecanoylphorbol Acetate	57-60	mitogen-activated protein kinase 1	Homo sapiens	278-282
12077118-0	2002	Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 1	Homo sapiens	97-100
12077118-0	2002	Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.	Tetradecanoylphorbol Acetate	0-31	nuclear factor kappa B subunit 1	Homo sapiens	106-116
12167592-10	2002	The stimulatory effects of LDL on PAI-1, tPA, and uPA gene regulation in HMC were blocked by the inhibition of PKC using GF-109203X 12 h after treatment with LDL or downregulation of PKC using phorbol myristate acetate.	Tetradecanoylphorbol Acetate	193-218	plasminogen activator, urokinase	Homo sapiens	50-53
12082101-6	2002	However, TPA-induced activation of PKC affected only Erk-2 activity, and GF-109203X (a PKC inhibitor) markedly suppressed UV-induced Erk-2 activation.	Tetradecanoylphorbol Acetate	9-12	mitogen-activated protein kinase 1	Homo sapiens	53-58
12082101-9	2002	In contrast, the suppression of Erk activation with PD98059, a specific inhibitor of MEK1, inhibited UV- and TPA-induced junD mRNA expression, UV-induced increases in caspase-3 activities, and cell death.	Tetradecanoylphorbol Acetate	109-112	mitogen-activated protein kinase 1	Homo sapiens	32-35
12082101-9	2002	In contrast, the suppression of Erk activation with PD98059, a specific inhibitor of MEK1, inhibited UV- and TPA-induced junD mRNA expression, UV-induced increases in caspase-3 activities, and cell death.	Tetradecanoylphorbol Acetate	109-112	caspase 3	Homo sapiens	167-176
12167592-10	2002	The stimulatory effects of LDL on PAI-1, tPA, and uPA gene regulation in HMC were blocked by the inhibition of PKC using GF-109203X 12 h after treatment with LDL or downregulation of PKC using phorbol myristate acetate.	Tetradecanoylphorbol Acetate	193-218	protein kinase C alpha	Homo sapiens	111-114
12204819-6	2002	A concentration of &gt; 0.2 nM TPA or 0.12 ng/mL (0.02 nM) EGF produced a significant increase in transformation response as well as in extracellular signal-regulated protein kinase (ERK), SRE, or AP-1 activation.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 1	Mus musculus	136-181
12193378-7	2002	Pretreatment of LbetaT2 cells with a mitogen-activated protein kinase kinase-specific inhibitor, U0126, abolished the PMA-stimulated increase in MAPK activity and significantly reduced basal and PMA-stimulated promoter activity.	Tetradecanoylphorbol Acetate	118-121	mitogen-activated protein kinase 3	Homo sapiens	145-149
12181747-4	2002	In Jurkat cells, TPA strongly activated ERK and inhibited the IR-induced caspase-8/Bid cleavage and the loss of DeltaPsi(m).	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase 1	Homo sapiens	40-43
12181747-4	2002	In Jurkat cells, TPA strongly activated ERK and inhibited the IR-induced caspase-8/Bid cleavage and the loss of DeltaPsi(m).	Tetradecanoylphorbol Acetate	17-20	BH3 interacting domain death agonist	Homo sapiens	83-86
12181747-5	2002	The inhibitory effect of TPA was mostly abrogated by pretreatment of a specific MEK inhibitor PD98059, indicating that the effect depends upon MEK/ERK-mediated signals.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase kinase 7	Homo sapiens	80-83
12181747-5	2002	The inhibitory effect of TPA was mostly abrogated by pretreatment of a specific MEK inhibitor PD98059, indicating that the effect depends upon MEK/ERK-mediated signals.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase kinase 7	Homo sapiens	143-146
12181747-5	2002	The inhibitory effect of TPA was mostly abrogated by pretreatment of a specific MEK inhibitor PD98059, indicating that the effect depends upon MEK/ERK-mediated signals.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase 1	Homo sapiens	147-150
12353857-0	2002	Nuclear factor-kappaB and TNF-alpha mediate gastric ulceration induced by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	74-99	tumor necrosis factor	Rattus norvegicus	26-35
12490289-7	2002	In parallel a greater increase of PKCalpha translocation after PMA treatment compared to controls was observed.	Tetradecanoylphorbol Acetate	63-66	protein kinase C alpha	Homo sapiens	34-42
12204819-6	2002	A concentration of &gt; 0.2 nM TPA or 0.12 ng/mL (0.02 nM) EGF produced a significant increase in transformation response as well as in extracellular signal-regulated protein kinase (ERK), SRE, or AP-1 activation.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 1	Mus musculus	183-186
12204819-9	2002	These findings suggest that the signaling pathway leading to the activation of ERK, TCF, and AP-1 proteins constitutes a major factor determining the risk of tumor promotion by TPA or EGF.	Tetradecanoylphorbol Acetate	177-180	mitogen-activated protein kinase 1	Mus musculus	79-82
12225365-2	2002	Phorbol 12-myristate 13-acetate (PMA) caused time- and concentration-dependent adhesion of AML cells to plated bovine serum albumin (BSA), which was blocked by anti-CD11b or anti-CD18 monoclonal antibodies (mAb) directed against beta2-integrin.	Tetradecanoylphorbol Acetate	0-31	albumin	Homo sapiens	118-131
12205039-4	2002	BK-induced COX-2 expression and prostaglandin E2 (PGE2) accumulation were mimicked by the direct PKC activator phorbol 12-myristate 13-acetate (PMA) and inhibited by the broad spectrum PKC inhibitor bisindolylmaleimide I.	Tetradecanoylphorbol Acetate	111-142	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
12205039-4	2002	BK-induced COX-2 expression and prostaglandin E2 (PGE2) accumulation were mimicked by the direct PKC activator phorbol 12-myristate 13-acetate (PMA) and inhibited by the broad spectrum PKC inhibitor bisindolylmaleimide I.	Tetradecanoylphorbol Acetate	111-142	protein kinase C alpha	Homo sapiens	97-100
12205039-4	2002	BK-induced COX-2 expression and prostaglandin E2 (PGE2) accumulation were mimicked by the direct PKC activator phorbol 12-myristate 13-acetate (PMA) and inhibited by the broad spectrum PKC inhibitor bisindolylmaleimide I.	Tetradecanoylphorbol Acetate	144-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16
12205039-4	2002	BK-induced COX-2 expression and prostaglandin E2 (PGE2) accumulation were mimicked by the direct PKC activator phorbol 12-myristate 13-acetate (PMA) and inhibited by the broad spectrum PKC inhibitor bisindolylmaleimide I.	Tetradecanoylphorbol Acetate	144-147	protein kinase C alpha	Homo sapiens	97-100
12205039-4	2002	BK-induced COX-2 expression and prostaglandin E2 (PGE2) accumulation were mimicked by the direct PKC activator phorbol 12-myristate 13-acetate (PMA) and inhibited by the broad spectrum PKC inhibitor bisindolylmaleimide I.	Tetradecanoylphorbol Acetate	144-147	protein kinase C alpha	Homo sapiens	185-188
12205041-5	2002	For Mono Mac 6 cells, priming with phorbol myristate acetate (PMA) before stimulation with ionophore was required for ERK1/2 activation and efficient 5-LO phosphorylation, in parallel with substantial AA release and 5-LO product formation.	Tetradecanoylphorbol Acetate	35-60	mitogen-activated protein kinase 3	Homo sapiens	118-124
12205041-5	2002	For Mono Mac 6 cells, priming with phorbol myristate acetate (PMA) before stimulation with ionophore was required for ERK1/2 activation and efficient 5-LO phosphorylation, in parallel with substantial AA release and 5-LO product formation.	Tetradecanoylphorbol Acetate	62-65	mitogen-activated protein kinase 3	Homo sapiens	118-124
12225365-2	2002	Phorbol 12-myristate 13-acetate (PMA) caused time- and concentration-dependent adhesion of AML cells to plated bovine serum albumin (BSA), which was blocked by anti-CD11b or anti-CD18 monoclonal antibodies (mAb) directed against beta2-integrin.	Tetradecanoylphorbol Acetate	0-31	integrin subunit beta 2	Homo sapiens	179-183
12225365-2	2002	Phorbol 12-myristate 13-acetate (PMA) caused time- and concentration-dependent adhesion of AML cells to plated bovine serum albumin (BSA), which was blocked by anti-CD11b or anti-CD18 monoclonal antibodies (mAb) directed against beta2-integrin.	Tetradecanoylphorbol Acetate	33-36	albumin	Homo sapiens	118-131
12225365-2	2002	Phorbol 12-myristate 13-acetate (PMA) caused time- and concentration-dependent adhesion of AML cells to plated bovine serum albumin (BSA), which was blocked by anti-CD11b or anti-CD18 monoclonal antibodies (mAb) directed against beta2-integrin.	Tetradecanoylphorbol Acetate	33-36	integrin subunit beta 2	Homo sapiens	179-183
12225365-6	2002	U0126, a MAPK/extracellular signal-regulated protein kinase kinase (MEK) inhibitor, at the concentrations that blocked PMA-induced ERK phosphorylation, had no effect on PMA stimulated AML cell adhesion.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 1	Homo sapiens	131-134
12009309-3	2002	METHODS: Using the JB6 cell model, we determined the involvement of PKC isoforms, mitogen-activated protein kinase kinase (MAPK kinase/MEK) and MAPK in TPA-induced OPN expression using inhibitors specific to PKC isoforms and MEK and performing Northern blot analyses.	Tetradecanoylphorbol Acetate	152-155	mitogen-activated protein kinase kinase 7	Homo sapiens	135-138
12009309-3	2002	METHODS: Using the JB6 cell model, we determined the involvement of PKC isoforms, mitogen-activated protein kinase kinase (MAPK kinase/MEK) and MAPK in TPA-induced OPN expression using inhibitors specific to PKC isoforms and MEK and performing Northern blot analyses.	Tetradecanoylphorbol Acetate	152-155	mitogen-activated protein kinase kinase 7	Homo sapiens	225-228
12009305-7	2002	For AP-1 binding activity induced by TPA, the repressive effect of ATRA was only observed in BGC-823 and RARalpha and RARbeta stably transfected MKN-45 cells, but not in intact MKN-45 cells.	Tetradecanoylphorbol Acetate	37-40	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-8
12211438-9	2002	The direct PKC stimulator 12-O-tetradecanoylphorbol-13-acetate (PMA) did not induce RANKL mRNA in MS1 cells, but it did up-regulate OPG mRNA and also antagonized osteoclast formation induced by PTH(1-34) in both MS1/spleen cocultures and normal bone marrow cultures.	Tetradecanoylphorbol Acetate	64-67	muscle size 1	Mus musculus	212-215
12009309-7	2002	Additionally, inhibition of MEK activity, which activates MAPK, attenuated TPA-induced OPN expression.	Tetradecanoylphorbol Acetate	75-78	mitogen-activated protein kinase kinase 7	Homo sapiens	28-31
12211438-9	2002	The direct PKC stimulator 12-O-tetradecanoylphorbol-13-acetate (PMA) did not induce RANKL mRNA in MS1 cells, but it did up-regulate OPG mRNA and also antagonized osteoclast formation induced by PTH(1-34) in both MS1/spleen cocultures and normal bone marrow cultures.	Tetradecanoylphorbol Acetate	26-62	muscle size 1	Mus musculus	212-215
12193227-6	2002	Moreover, they inhibited chemotaxis, phagocytosis of Escherichia coli and PMA-stimulated production of hydrogen peroxide in THP-1 differentiated to macrophage-like cells.	Tetradecanoylphorbol Acetate	74-77	GLI family zinc finger 2	Homo sapiens	124-129
12231177-4	2002	Activation of protein kinase C in CD34(+) cells with the phorbol ester PMA (phorbol 12-myristate 13-acetate) increased the mRNA level of the GALV receptor (GLVR1) and the transduction efficiency (TE), and fully reversed the inhibition of transduction seen with high-titer GALV VCM.	Tetradecanoylphorbol Acetate	76-107	CD34 molecule	Homo sapiens	34-38
12193740-6	2002	As a further control, we used PMA, which activates ERK phosphorylation by postmembrane receptor induction of protein kinase C, a mechanism which bypasses Ras.	Tetradecanoylphorbol Acetate	30-33	mitogen-activated protein kinase 1	Homo sapiens	51-54
12205158-9	2002	Down-regulation of protein kinase C (PKC) with the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) or PKC inhibition with bisindolylmaleimide attenuated the actions of PACAP, indicating that PKC also couples PACAP to potentiation of depolarization-induced Ca(2+) transients.	Tetradecanoylphorbol Acetate	104-107	proline rich transmembrane protein 2	Homo sapiens	19-35
12205158-9	2002	Down-regulation of protein kinase C (PKC) with the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) or PKC inhibition with bisindolylmaleimide attenuated the actions of PACAP, indicating that PKC also couples PACAP to potentiation of depolarization-induced Ca(2+) transients.	Tetradecanoylphorbol Acetate	104-107	proline rich transmembrane protein 2	Homo sapiens	37-40
12474565-6	2002	A positive correlation between area under insulin curve and PAI-1 activity and a negative correlation between fasting insulin levels and tPA were also observed.	Tetradecanoylphorbol Acetate	137-140	insulin	Homo sapiens	118-125
12110540-4	2002	Phorbol 12-myristrate 13-acetate (PMA) activated PKC-alpha and exogenous PKC-delta but not atypical PKC-lambda/zeta.	Tetradecanoylphorbol Acetate	34-37	protein kinase C alpha	Homo sapiens	49-58
12048182-5	2002	Phorbol 12-myristate 13-acetate, a differentiation-inducing stimulus, potently activates the Ras-Raf-MEK-ERK pathway but only weakly activates PI3K/Akt and does not trigger the cross-talk.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase kinase 7	Homo sapiens	101-104
12048182-5	2002	Phorbol 12-myristate 13-acetate, a differentiation-inducing stimulus, potently activates the Ras-Raf-MEK-ERK pathway but only weakly activates PI3K/Akt and does not trigger the cross-talk.	Tetradecanoylphorbol Acetate	0-31	AKT serine/threonine kinase 1	Homo sapiens	148-151
12039947-7	2002	Inhibition of 12-O-tetradecanoyl-phorbol-13-acetate-stimulated IL-8 production by 1-butanol further strengthened this observation.	Tetradecanoylphorbol Acetate	14-51	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
12114186-6	2002	Secretion of SP-B, SP-C, and phosphatidylcholine was stimulated by phorbol 12-myristate 13-acetate and was inhibited by compound 48/80.	Tetradecanoylphorbol Acetate	67-98	sparse coat	Mus musculus	19-23
12052829-3	2002	In this work, we have identified 12-O-tetradecanoylphorbol-13-acetate (TPA)- and growth factor-induced serine/threonine phosphorylation sites in p52(Shc) and p66(Shc).	Tetradecanoylphorbol Acetate	33-69	SHC adaptor protein 1	Rattus norvegicus	158-166
12052829-3	2002	In this work, we have identified 12-O-tetradecanoylphorbol-13-acetate (TPA)- and growth factor-induced serine/threonine phosphorylation sites in p52(Shc) and p66(Shc).	Tetradecanoylphorbol Acetate	71-74	SHC adaptor protein 1	Rattus norvegicus	158-166
12052829-4	2002	Among them, Ser(29) in p52(Shc) (equivalent to Ser(138) in p66(Shc)) was phosphorylated only after TPA stimulation.	Tetradecanoylphorbol Acetate	99-102	SHC adaptor protein 1	Rattus norvegicus	59-67
11997388-7	2002	The ionomycin-induced transient translocation of PKCalpha-GFP was prolonged by staurosporine, diacylglycerol, and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	114-139	protein kinase C alpha	Homo sapiens	49-57
12110518-4	2002	In our study, activation of protein kinase C (PKC) using phorbol esters (phorbol 12-myristate 13-acetate) leads to clathrin-dependent internalization and intracellular accumulation of the ion pump in stably transfected Madin-Darby canine kidney cells.	Tetradecanoylphorbol Acetate	73-104	proline rich transmembrane protein 2	Homo sapiens	28-44
12110518-4	2002	In our study, activation of protein kinase C (PKC) using phorbol esters (phorbol 12-myristate 13-acetate) leads to clathrin-dependent internalization and intracellular accumulation of the ion pump in stably transfected Madin-Darby canine kidney cells.	Tetradecanoylphorbol Acetate	73-104	proline rich transmembrane protein 2	Homo sapiens	46-49
12110540-9	2002	These findings demonstrate that both conventional and novel PKC isoforms are involved in PMA-stimulated glucose transport and that other novel PKC isoforms could participate in PMA-stimulated and insulin-stimulated glucose transport.	Tetradecanoylphorbol Acetate	89-92	protein kinase C alpha	Homo sapiens	60-63
12110540-9	2002	These findings demonstrate that both conventional and novel PKC isoforms are involved in PMA-stimulated glucose transport and that other novel PKC isoforms could participate in PMA-stimulated and insulin-stimulated glucose transport.	Tetradecanoylphorbol Acetate	177-180	protein kinase C alpha	Homo sapiens	143-146
12060668-5	2002	This factor, which was named cytoguardin, suppressed COX-2 protein levels induced by phorbol 12-myristate 13-acetate, interleukin-1beta, tumor necrosis factor alpha, and lipopolysaccharide (LPS) in fibroblasts and LPS-induced COX-2 protein levels and promoter activities in human endothelial cells and murine RAW 264.7 cells in a comparable concentration-dependent manner.	Tetradecanoylphorbol Acetate	85-116	prostaglandin-endoperoxide synthase 2	Homo sapiens	53-58
12180971-1	2002	Our laboratory showed that bikunin, a Kunitz-type protease inhibitor, suppresses 4beta-phorbol 12-myristate 13-acetate (PMA)- or tumor necrosis factor-alpha (TNFalpha)-induced urokinase-type plasminogen activator (uPA) expression in different cell types.	Tetradecanoylphorbol Acetate	81-118	plasminogen activator, urokinase	Homo sapiens	176-212
12187329-6	2002	Whereas TPA treatment resulted in a strong induction of p21(WAF/CIP1), c-Fos and c-Jun levels, neither one of the novel PKC activators altered expression of these proteins.	Tetradecanoylphorbol Acetate	8-11	cyclin dependent kinase inhibitor 1A	Homo sapiens	56-59
12187329-6	2002	Whereas TPA treatment resulted in a strong induction of p21(WAF/CIP1), c-Fos and c-Jun levels, neither one of the novel PKC activators altered expression of these proteins.	Tetradecanoylphorbol Acetate	8-11	cyclin dependent kinase inhibitor 1A	Homo sapiens	64-68
12187329-8	2002	While TPA treatment resulted in translocation of the PKC isoforms alpha, delta and epsilon, SC-10 and FTT failed to induce alterations in the PKC content of the membrane and cytosolic fractions, respectively.	Tetradecanoylphorbol Acetate	6-9	protein kinase C alpha	Homo sapiens	53-97
12187329-8	2002	While TPA treatment resulted in translocation of the PKC isoforms alpha, delta and epsilon, SC-10 and FTT failed to induce alterations in the PKC content of the membrane and cytosolic fractions, respectively.	Tetradecanoylphorbol Acetate	6-9	protein kinase C alpha	Homo sapiens	53-56
12214859-3	2002	Previous studies from this laboratory revealed that capsaicin, when topically applied onto dorsal skin of female ICR mice, strongly attenuated activation of NF-kappaB and AP-1 induced by the typical tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), which may account for its anti-tumor promoting activity in mouse skin.	Tetradecanoylphorbol Acetate	215-251	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-166
12214859-4	2002	In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kappaB through inhibition of IkappaB alpha degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells.	Tetradecanoylphorbol Acetate	61-64	nuclear factor kappa B subunit 1	Homo sapiens	90-99
12214859-4	2002	In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kappaB through inhibition of IkappaB alpha degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells.	Tetradecanoylphorbol Acetate	61-64	NFKB inhibitor alpha	Homo sapiens	122-135
12363040-6	2002	The appearance of CD10 on the cell surface was blocked by preincubation of the cells with the monocytic/macrophage-differentiating agents vitamin D3 and phorbol 12-myristate 13-acetate, but not by the granulocytic differentiating agents retinoic acid or dimethyl sulfoxide.	Tetradecanoylphorbol Acetate	153-184	membrane metalloendopeptidase	Homo sapiens	18-22
12133811-0	2002	Isoforms of apolipoprotein E can modulate tPA-induced clot lysis in vitro.	Tetradecanoylphorbol Acetate	42-45	apolipoprotein E	Homo sapiens	12-28
12133811-2	2002	The effectiveness of intravenous tPA in patients with acute ischemic stroke appears to be enhanced in patients who have an Apo E2 phenotype.	Tetradecanoylphorbol Acetate	33-36	apolipoprotein E	Homo sapiens	123-129
12133811-3	2002	The ability of Apo E isoproteins (endogenous Apo E isoproteins or exogenous Apo E isoproteins) to modulate tPA-induced clot lysis in vitro was assessed using an in vitro clot assay system.	Tetradecanoylphorbol Acetate	107-110	apolipoprotein E	Homo sapiens	15-20
12115530-6	2002	TPA-stimulated expression of epidermal COX-2 and iNOS was also mitigated by topical application of the same extract.	Tetradecanoylphorbol Acetate	0-3	nitric oxide synthase 2, inducible	Mus musculus	49-53
12133811-3	2002	The ability of Apo E isoproteins (endogenous Apo E isoproteins or exogenous Apo E isoproteins) to modulate tPA-induced clot lysis in vitro was assessed using an in vitro clot assay system.	Tetradecanoylphorbol Acetate	107-110	apolipoprotein E	Homo sapiens	45-50
12133811-3	2002	The ability of Apo E isoproteins (endogenous Apo E isoproteins or exogenous Apo E isoproteins) to modulate tPA-induced clot lysis in vitro was assessed using an in vitro clot assay system.	Tetradecanoylphorbol Acetate	107-110	apolipoprotein E	Homo sapiens	45-50
12133811-6	2002	tPA-induced clot lysis was significantly (P equal or less than 0.0001) enhanced by supplementation with Apo E2 (EC50 0.20 0.06 microgram/ml) as compared to tPA alone (0.72 0.19).	Tetradecanoylphorbol Acetate	0-3	apolipoprotein E	Homo sapiens	104-110
12133811-6	2002	tPA-induced clot lysis was significantly (P equal or less than 0.0001) enhanced by supplementation with Apo E2 (EC50 0.20 0.06 microgram/ml) as compared to tPA alone (0.72 0.19).	Tetradecanoylphorbol Acetate	156-159	apolipoprotein E	Homo sapiens	104-110
12115530-7	2002	Moreover, DA-9601 abrogated the TPA-mediated activation of NF-kappa B/Rel and AP-1 in mouse epidermis.	Tetradecanoylphorbol Acetate	32-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	59-69
12133875-7	2002	Intracellular expression of IFN-gamma, IL-2, and IL-4 was detected in CD4(+) and CD8(+) T cells after stimulation with phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	119-150	interferon gamma	Homo sapiens	28-37
12184631-7	2002	These results indicate that the change in intracellular redox state could be involved in the up-regulation of CD13/APN expression during TPA-induced differentiation of HL-60 cells, suggesting that TNFalpha may serve as, at least, one of the signals stimulated by TPA.	Tetradecanoylphorbol Acetate	137-140	tumor necrosis factor	Homo sapiens	197-205
12184631-7	2002	These results indicate that the change in intracellular redox state could be involved in the up-regulation of CD13/APN expression during TPA-induced differentiation of HL-60 cells, suggesting that TNFalpha may serve as, at least, one of the signals stimulated by TPA.	Tetradecanoylphorbol Acetate	263-266	tumor necrosis factor	Homo sapiens	197-205
12117969-4	2002	Vascular endothelial growth factor (VEGF), a direct inducer of angiogenesis, and interleukin-1beta (IL-1beta), a potentiator of VEGF, were detected within 12 and 6 h, respectively, in supernatants from phorbol 12-myristate 13-acetate-differentiated human THP-1 macrophages exposed to live B. henselae.	Tetradecanoylphorbol Acetate	202-233	vascular endothelial growth factor A	Homo sapiens	0-34
12117969-4	2002	Vascular endothelial growth factor (VEGF), a direct inducer of angiogenesis, and interleukin-1beta (IL-1beta), a potentiator of VEGF, were detected within 12 and 6 h, respectively, in supernatants from phorbol 12-myristate 13-acetate-differentiated human THP-1 macrophages exposed to live B. henselae.	Tetradecanoylphorbol Acetate	202-233	interleukin 1 beta	Homo sapiens	81-98
12117969-4	2002	Vascular endothelial growth factor (VEGF), a direct inducer of angiogenesis, and interleukin-1beta (IL-1beta), a potentiator of VEGF, were detected within 12 and 6 h, respectively, in supernatants from phorbol 12-myristate 13-acetate-differentiated human THP-1 macrophages exposed to live B. henselae.	Tetradecanoylphorbol Acetate	202-233	interleukin 1 beta	Homo sapiens	100-108
12133875-7	2002	Intracellular expression of IFN-gamma, IL-2, and IL-4 was detected in CD4(+) and CD8(+) T cells after stimulation with phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	119-150	interleukin 2	Homo sapiens	39-43
12133875-7	2002	Intracellular expression of IFN-gamma, IL-2, and IL-4 was detected in CD4(+) and CD8(+) T cells after stimulation with phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	119-150	interleukin 4	Homo sapiens	49-53
12133875-7	2002	Intracellular expression of IFN-gamma, IL-2, and IL-4 was detected in CD4(+) and CD8(+) T cells after stimulation with phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	119-150	CD4 molecule	Homo sapiens	70-73
12400610-6	2002	Evidence that RAFTK is a modulator of Akt came from phorbol myristic acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	78-81	AKT serine/threonine kinase 1	Homo sapiens	38-41
12161520-3	2002	Electrophoretic mobility shift assay revealed that TNF alpha (1 ng/ml) and phorbol 12-myristate 13-acetate (TPA; 0.4 micro M), PKC activator, caused marked increases in nuclear NF-kappa B DNA binding activity.	Tetradecanoylphorbol Acetate	75-106	plasminogen activator, tissue type	Homo sapiens	108-111
12161520-3	2002	Electrophoretic mobility shift assay revealed that TNF alpha (1 ng/ml) and phorbol 12-myristate 13-acetate (TPA; 0.4 micro M), PKC activator, caused marked increases in nuclear NF-kappa B DNA binding activity.	Tetradecanoylphorbol Acetate	75-106	proline rich transmembrane protein 2	Homo sapiens	127-130
12161520-3	2002	Electrophoretic mobility shift assay revealed that TNF alpha (1 ng/ml) and phorbol 12-myristate 13-acetate (TPA; 0.4 micro M), PKC activator, caused marked increases in nuclear NF-kappa B DNA binding activity.	Tetradecanoylphorbol Acetate	75-106	nuclear factor kappa B subunit 1	Homo sapiens	177-187
12130708-4	2002	Furthermore, depletion of PKC by 12-O-tetradecanoylphorbol-13-acetate exposure (48 h, 1 microM) also prevented OFQ/N-mediated mu and ORL1 desensitization.	Tetradecanoylphorbol Acetate	33-69	protein kinase C alpha	Homo sapiens	26-29
12203369-3	2002	Two protein kinase C (PKC) isoforms, conventional PKC (cPKC) and novel PKC (nPKC), but not apical PKC, translocated from the cytosolic to the particulate fraction upon TPA treatment.	Tetradecanoylphorbol Acetate	168-171	protein kinase C alpha	Homo sapiens	22-25
12203369-3	2002	Two protein kinase C (PKC) isoforms, conventional PKC (cPKC) and novel PKC (nPKC), but not apical PKC, translocated from the cytosolic to the particulate fraction upon TPA treatment.	Tetradecanoylphorbol Acetate	168-171	protein kinase C alpha	Homo sapiens	50-53
12203369-3	2002	Two protein kinase C (PKC) isoforms, conventional PKC (cPKC) and novel PKC (nPKC), but not apical PKC, translocated from the cytosolic to the particulate fraction upon TPA treatment.	Tetradecanoylphorbol Acetate	168-171	protein kinase C alpha	Homo sapiens	50-53
12203369-3	2002	Two protein kinase C (PKC) isoforms, conventional PKC (cPKC) and novel PKC (nPKC), but not apical PKC, translocated from the cytosolic to the particulate fraction upon TPA treatment.	Tetradecanoylphorbol Acetate	168-171	protein kinase C alpha	Homo sapiens	50-53
12203369-8	2002	Furthermore, PKC inhibitors or an MEK inhibitor completely suppressed both TPA-induced activation of MAPK and promotion of anchorage-independent growth, but a cPKC-selective inhibitor partially suppressed TPA-induced promotion of the growth.	Tetradecanoylphorbol Acetate	75-78	protein kinase C alpha	Homo sapiens	13-16
12203369-8	2002	Furthermore, PKC inhibitors or an MEK inhibitor completely suppressed both TPA-induced activation of MAPK and promotion of anchorage-independent growth, but a cPKC-selective inhibitor partially suppressed TPA-induced promotion of the growth.	Tetradecanoylphorbol Acetate	75-78	mitogen-activated protein kinase kinase 7	Homo sapiens	34-37
12130714-2	2002	We examined the effect of phorbol 12-myristate 13-acetate (PMA), a direct activator of PKC, on Kv1.5 current.	Tetradecanoylphorbol Acetate	26-57	potassium voltage-gated channel subfamily A member 5	Homo sapiens	95-100
12130714-2	2002	We examined the effect of phorbol 12-myristate 13-acetate (PMA), a direct activator of PKC, on Kv1.5 current.	Tetradecanoylphorbol Acetate	59-62	potassium voltage-gated channel subfamily A member 5	Homo sapiens	95-100
12225809-2	2002	In this study we found that exogenously added TSP-1 inhibits phorbol myristate acetate (PMA)/LPS-induced homotypic aggregation of human monocytic U937 cells, whereas the 70-kDa fragment of TSP-1 generated by the proteolytic cleavage of the intact molecule promotes the homotypic aggregation.	Tetradecanoylphorbol Acetate	61-86	thrombospondin 1	Homo sapiens	46-51
12225809-2	2002	In this study we found that exogenously added TSP-1 inhibits phorbol myristate acetate (PMA)/LPS-induced homotypic aggregation of human monocytic U937 cells, whereas the 70-kDa fragment of TSP-1 generated by the proteolytic cleavage of the intact molecule promotes the homotypic aggregation.	Tetradecanoylphorbol Acetate	88-91	thrombospondin 1	Homo sapiens	46-51
12167345-3	2002	After stimulation with phorbol 12-myristate 13-acetate and ionomycin, an increase in the percentage of IFN-gamma and IL-4 producing CD8(+) T cells was observed during aging.	Tetradecanoylphorbol Acetate	23-54	interferon gamma	Homo sapiens	103-112
12138205-10	2002	This mutated form of Cot also acts as a dominant negative for T-cell antigen receptor/CD28- or Akt/phorbol myristate acetate-induced NF-kappa B induction, while having relatively little effect on tumor necrosis factor induction of NF-kappa B.	Tetradecanoylphorbol Acetate	99-124	nuclear factor kappa B subunit 1	Homo sapiens	133-143
12182941-2	2002	Regulation of the cell content of alpha-MSH and beta-endorphin occurred in two phases consisting of (a) initial depletion of cellular levels of these peptide hormones during short-term secretion (3 h) induced by isoproterenol, forskolin, or phorbol myristate acetate (PMA) which was followed by (b) long-term (24 h) increases in cellular levels of alpha-MSH and beta-endorphin in response to stimulated secretion induced by isoproterenol and PMA.	Tetradecanoylphorbol Acetate	241-266	proopiomelanocortin	Homo sapiens	34-43
12182941-2	2002	Regulation of the cell content of alpha-MSH and beta-endorphin occurred in two phases consisting of (a) initial depletion of cellular levels of these peptide hormones during short-term secretion (3 h) induced by isoproterenol, forskolin, or phorbol myristate acetate (PMA) which was followed by (b) long-term (24 h) increases in cellular levels of alpha-MSH and beta-endorphin in response to stimulated secretion induced by isoproterenol and PMA.	Tetradecanoylphorbol Acetate	268-271	proopiomelanocortin	Homo sapiens	34-43
12182941-2	2002	Regulation of the cell content of alpha-MSH and beta-endorphin occurred in two phases consisting of (a) initial depletion of cellular levels of these peptide hormones during short-term secretion (3 h) induced by isoproterenol, forskolin, or phorbol myristate acetate (PMA) which was followed by (b) long-term (24 h) increases in cellular levels of alpha-MSH and beta-endorphin in response to stimulated secretion induced by isoproterenol and PMA.	Tetradecanoylphorbol Acetate	442-445	proopiomelanocortin	Homo sapiens	34-43
12182941-6	2002	Treatment with PMA for 24 h also increased cellular levels of alpha-MSH and beta-endorphin.	Tetradecanoylphorbol Acetate	15-18	proopiomelanocortin	Homo sapiens	62-71
12182941-6	2002	Treatment with PMA for 24 h also increased cellular levels of alpha-MSH and beta-endorphin.	Tetradecanoylphorbol Acetate	15-18	proopiomelanocortin	Homo sapiens	76-90
12118374-12	2002	Taken together, our data demonstrate that PMA-mediated inhibition of apoptosis is a complex process that is integrated at both the transcriptional and post-transcriptional level and point out to the potential role of Mcl-1, Bcl-x, c-Myc and survivin in this process.	Tetradecanoylphorbol Acetate	42-45	BCL2 like 1	Homo sapiens	224-229
12084577-3	2002	The role of cis-acting elements within the CFTR minimal promoter in modulating responses to phorbol 12-myristate 13-acetate (PMA) and forskolin was assessed using luciferase reporter gene (luc)-containing plasmids transfected into Calu-3 and HT-29 cells.	Tetradecanoylphorbol Acetate	92-123	CF transmembrane conductance regulator	Homo sapiens	43-47
12084577-3	2002	The role of cis-acting elements within the CFTR minimal promoter in modulating responses to phorbol 12-myristate 13-acetate (PMA) and forskolin was assessed using luciferase reporter gene (luc)-containing plasmids transfected into Calu-3 and HT-29 cells.	Tetradecanoylphorbol Acetate	125-128	CF transmembrane conductance regulator	Homo sapiens	43-47
12101411-3	2002	The induction of a specific subset of AP-1 responsive genes thought to be important for tumour development, namely GM-CSF, MMP-9 and MMP-3, was suppressed in TNF-alpha(-/-) compared to wild-type mouse skin in response to the tumour promotor TPA.	Tetradecanoylphorbol Acetate	241-244	tumor necrosis factor	Mus musculus	158-167
12167345-3	2002	After stimulation with phorbol 12-myristate 13-acetate and ionomycin, an increase in the percentage of IFN-gamma and IL-4 producing CD8(+) T cells was observed during aging.	Tetradecanoylphorbol Acetate	23-54	interleukin 4	Homo sapiens	117-121
12101411-5	2002	The major receptor for TPA-induced signalling in basal keratinocytes, PKC alpha, was also differentially regulated in wild-type compared with TNF-alpha(-/-) epidermis.	Tetradecanoylphorbol Acetate	23-26	protein kinase C, alpha	Mus musculus	70-79
12453641-10	2002	The present study focused on the glypican-1, syndecan-1 and syndecan-4 mRNA expression and regulation under PKC activation by the phorbol myristate acetate (PMA) in 10-30 day-old Sertoli cells.	Tetradecanoylphorbol Acetate	130-155	glypican 1	Rattus norvegicus	33-43
12101411-5	2002	The major receptor for TPA-induced signalling in basal keratinocytes, PKC alpha, was also differentially regulated in wild-type compared with TNF-alpha(-/-) epidermis.	Tetradecanoylphorbol Acetate	23-26	tumor necrosis factor	Mus musculus	142-151
12101411-6	2002	A marked delay in TPA-induced intracellular translocation and downregulation of PKC alpha was observed in TNF-alpha(-/-) epidermis, which correlated with the deregulated TPA-induced AP-1 activation and c-Jun expression.	Tetradecanoylphorbol Acetate	18-21	protein kinase C, alpha	Mus musculus	80-89
12101411-6	2002	A marked delay in TPA-induced intracellular translocation and downregulation of PKC alpha was observed in TNF-alpha(-/-) epidermis, which correlated with the deregulated TPA-induced AP-1 activation and c-Jun expression.	Tetradecanoylphorbol Acetate	18-21	tumor necrosis factor	Mus musculus	106-115
12101411-6	2002	A marked delay in TPA-induced intracellular translocation and downregulation of PKC alpha was observed in TNF-alpha(-/-) epidermis, which correlated with the deregulated TPA-induced AP-1 activation and c-Jun expression.	Tetradecanoylphorbol Acetate	170-173	protein kinase C, alpha	Mus musculus	80-89
12101411-6	2002	A marked delay in TPA-induced intracellular translocation and downregulation of PKC alpha was observed in TNF-alpha(-/-) epidermis, which correlated with the deregulated TPA-induced AP-1 activation and c-Jun expression.	Tetradecanoylphorbol Acetate	170-173	tumor necrosis factor	Mus musculus	106-115
12083800-7	2002	Following treatment with a PKC activator, phorbol 12-myristate 13-acetate (PMA), CGs were released and PKCalpha and -gamma were translocated to the membrane.	Tetradecanoylphorbol Acetate	42-73	protein kinase C alpha	Homo sapiens	27-30
12083800-7	2002	Following treatment with a PKC activator, phorbol 12-myristate 13-acetate (PMA), CGs were released and PKCalpha and -gamma were translocated to the membrane.	Tetradecanoylphorbol Acetate	42-73	protein kinase C alpha	Homo sapiens	103-122
12083800-7	2002	Following treatment with a PKC activator, phorbol 12-myristate 13-acetate (PMA), CGs were released and PKCalpha and -gamma were translocated to the membrane.	Tetradecanoylphorbol Acetate	75-78	protein kinase C alpha	Homo sapiens	27-30
12083800-7	2002	Following treatment with a PKC activator, phorbol 12-myristate 13-acetate (PMA), CGs were released and PKCalpha and -gamma were translocated to the membrane.	Tetradecanoylphorbol Acetate	75-78	protein kinase C alpha	Homo sapiens	103-122
11983688-3	2002	DHMEQ inhibited tumor necrosis factor-alpha (TNF-alpha)- and 12-O-tetradecanoylphorbol-13-acetate-induced transcriptional activity of NF-kappaB in human T cell leukemia Jurkat cells.	Tetradecanoylphorbol Acetate	61-97	nuclear factor kappa B subunit 1	Homo sapiens	134-143
12076508-4	2002	Short term exposure to phorbol 12-myristate 13-acetate (TPA), a phorbol ester tumour promoter, or hydrogen peroxide (H(2)O(2)) also activates AP-1 and NF-kappa B binding.	Tetradecanoylphorbol Acetate	23-54	nuclear factor kappa B subunit 1	Homo sapiens	151-161
12076508-4	2002	Short term exposure to phorbol 12-myristate 13-acetate (TPA), a phorbol ester tumour promoter, or hydrogen peroxide (H(2)O(2)) also activates AP-1 and NF-kappa B binding.	Tetradecanoylphorbol Acetate	56-59	nuclear factor kappa B subunit 1	Homo sapiens	151-161
12100761-1	2002	AIM: To examine the effect of mycophenolic acid (MPA) on the activity of nuclear factor-kappaB (NF-kappaB) and its inhibitor (IkappaBalpha) in 4-phorbal-12-myristate-13-acetate (PMA) stimulated and non-stimulated human umbilical vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	178-181	nuclear factor kappa B subunit 1	Homo sapiens	73-94
12100761-1	2002	AIM: To examine the effect of mycophenolic acid (MPA) on the activity of nuclear factor-kappaB (NF-kappaB) and its inhibitor (IkappaBalpha) in 4-phorbal-12-myristate-13-acetate (PMA) stimulated and non-stimulated human umbilical vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	178-181	nuclear factor kappa B subunit 1	Homo sapiens	96-105
12100761-4	2002	RESULTS: Incubation with PMA was found to result in rapid increment of NF-kappaB activity in cultured HUVEC.	Tetradecanoylphorbol Acetate	25-28	nuclear factor kappa B subunit 1	Homo sapiens	71-80
12453641-10	2002	The present study focused on the glypican-1, syndecan-1 and syndecan-4 mRNA expression and regulation under PKC activation by the phorbol myristate acetate (PMA) in 10-30 day-old Sertoli cells.	Tetradecanoylphorbol Acetate	157-160	glypican 1	Rattus norvegicus	33-43
12429947-3	2002	Instead, administration of UCN-01 with PMA led to a marked increase in mitochondrial injury (e.g, cytochrome c release), activation of caspases-3 and -8, Bid cleavage, PARP degradation, and apoptosis, accompanied by a substantial reduction in viability and clonogenic survival.	Tetradecanoylphorbol Acetate	39-42	cytochrome c, somatic	Homo sapiens	98-110
12110618-2	2002	The phorbol ester TPA, an activator of protein kinase C (PKC), inhibits cholinergic stimulation of gastric acid secretion but increases basal H(+) secretion.	Tetradecanoylphorbol Acetate	18-21	protein kinase C alpha	Homo sapiens	57-60
12429947-3	2002	Instead, administration of UCN-01 with PMA led to a marked increase in mitochondrial injury (e.g, cytochrome c release), activation of caspases-3 and -8, Bid cleavage, PARP degradation, and apoptosis, accompanied by a substantial reduction in viability and clonogenic survival.	Tetradecanoylphorbol Acetate	39-42	caspase 3	Homo sapiens	135-152
12429947-3	2002	Instead, administration of UCN-01 with PMA led to a marked increase in mitochondrial injury (e.g, cytochrome c release), activation of caspases-3 and -8, Bid cleavage, PARP degradation, and apoptosis, accompanied by a substantial reduction in viability and clonogenic survival.	Tetradecanoylphorbol Acetate	39-42	BH3 interacting domain death agonist	Homo sapiens	154-157
12061815-0	2002	The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process.	Tetradecanoylphorbol Acetate	81-106	tumor necrosis factor	Homo sapiens	200-227
12091247-2	2002	We have recently shown that phorbol 13-myristate 12-acetate (PMA)-stimulated SPRR1B transcription in Clara-like H441 cells is mainly mediated by activator protein-1 (AP-1) and c-Jun N-terminal kinase-1 (JNK1).	Tetradecanoylphorbol Acetate	61-64	mitogen-activated protein kinase 8	Homo sapiens	176-201
12091247-2	2002	We have recently shown that phorbol 13-myristate 12-acetate (PMA)-stimulated SPRR1B transcription in Clara-like H441 cells is mainly mediated by activator protein-1 (AP-1) and c-Jun N-terminal kinase-1 (JNK1).	Tetradecanoylphorbol Acetate	61-64	mitogen-activated protein kinase 8	Homo sapiens	203-207
12061815-0	2002	The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process.	Tetradecanoylphorbol Acetate	108-111	tumor necrosis factor	Homo sapiens	200-227
11940578-3	2002	To explore the importance of the c-Raf/MAPK kinase (MEK)/MAPK pathway, we stimulated adult feline cardiomyocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA), insulin, or forskolin to activate PKC, phosphatidylinositol-3-OH kinase, or protein kinase A (PKA), respectively.	Tetradecanoylphorbol Acetate	118-154	mitogen-activated protein kinase kinase 7	Homo sapiens	52-55
12134900-2	2002	In the present study, by assessing the effect of a specific p38 mitogen-activated protein kinase (MAPK) inhibitor, SB203580, on the secretion of MMPs and in vitro invasion of various glioma cells, the authors attempt to define the role of the p38 MAPK pathway in the regulation of MMPs and tissue inhibitors of metalloproteinases (TIMPs) activated by phorbol ester (phorbol-12-myristate-13-acetate [PMA]) in the D54 human glioblastoma cell line.	Tetradecanoylphorbol Acetate	366-397	mitogen-activated protein kinase 3	Homo sapiens	98-102
12134900-4	2002	Treatment of D54 cells with PMA activated two distinct MAPKs, extracellular signal-regulated kinase (ERK) 1/2 and p38 MAPK, but not c-Jun N-terminal kinase/stress-activated protein kinase.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 3	Homo sapiens	62-109
12134900-6	2002	In addition, PMA-induced downregulation of TIMP-1 and TIMP-2 secretion and upregulation of the membrane type I MMP, a major activator of MMP-2 on the cell surface, were reversed by SB203580 in these cells; the PMA-induced increase of invasion in vitro decreased when SB203580 was added to the top compartment of a modified Boyden chamber; and the inhibitor also reduced the MMP secretion and PMA-induced in vitro invasion in various glioma cell lines.	Tetradecanoylphorbol Acetate	13-16	TIMP metallopeptidase inhibitor 1	Homo sapiens	43-49
12137745-4	2002	The purpose of this study was to clarify the enhancement of NEP/CD10 expression and its signal transduction pathway during phorbol ester (PMA)-induced differentiation of BeWo choriocarcinoma cells.	Tetradecanoylphorbol Acetate	138-141	membrane metalloendopeptidase	Homo sapiens	60-63
12137745-4	2002	The purpose of this study was to clarify the enhancement of NEP/CD10 expression and its signal transduction pathway during phorbol ester (PMA)-induced differentiation of BeWo choriocarcinoma cells.	Tetradecanoylphorbol Acetate	138-141	membrane metalloendopeptidase	Homo sapiens	64-68
12137745-6	2002	On immunoblot analysis, PMA enhanced NEP/CD10 expression in a dose- and time-dependent manner, which was completely abolished by Bis I and a mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitor, PD98059.	Tetradecanoylphorbol Acetate	24-27	membrane metalloendopeptidase	Homo sapiens	37-40
12137745-6	2002	On immunoblot analysis, PMA enhanced NEP/CD10 expression in a dose- and time-dependent manner, which was completely abolished by Bis I and a mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitor, PD98059.	Tetradecanoylphorbol Acetate	24-27	membrane metalloendopeptidase	Homo sapiens	41-45
12137745-6	2002	On immunoblot analysis, PMA enhanced NEP/CD10 expression in a dose- and time-dependent manner, which was completely abolished by Bis I and a mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitor, PD98059.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase kinase 7	Homo sapiens	189-192
12137745-7	2002	PMA also induced phosphorylation of p44/p42 extracellular signal-regulated kinases (ERK) 1 and 2.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	84-87
12074591-2	2002	In G361 cell line, which lacks PKCalpha, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced PLD activation was potentiated by introducing PKCalpha by the adenovirus vector.	Tetradecanoylphorbol Acetate	41-77	protein kinase C alpha	Homo sapiens	31-39
12074591-2	2002	In G361 cell line, which lacks PKCalpha, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced PLD activation was potentiated by introducing PKCalpha by the adenovirus vector.	Tetradecanoylphorbol Acetate	41-77	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	92-95
12074591-2	2002	In G361 cell line, which lacks PKCalpha, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced PLD activation was potentiated by introducing PKCalpha by the adenovirus vector.	Tetradecanoylphorbol Acetate	41-77	protein kinase C alpha	Homo sapiens	138-146
12074591-2	2002	In G361 cell line, which lacks PKCalpha, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced PLD activation was potentiated by introducing PKCalpha by the adenovirus vector.	Tetradecanoylphorbol Acetate	79-82	protein kinase C alpha	Homo sapiens	31-39
12074591-2	2002	In G361 cell line, which lacks PKCalpha, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced PLD activation was potentiated by introducing PKCalpha by the adenovirus vector.	Tetradecanoylphorbol Acetate	79-82	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	92-95
12074591-2	2002	In G361 cell line, which lacks PKCalpha, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced PLD activation was potentiated by introducing PKCalpha by the adenovirus vector.	Tetradecanoylphorbol Acetate	79-82	protein kinase C alpha	Homo sapiens	138-146
12074591-3	2002	The kinase-negative PKCalpha elevated TPA-induced PLD activity less significantly than the wild type.	Tetradecanoylphorbol Acetate	38-41	protein kinase C alpha	Homo sapiens	20-28
12074591-3	2002	The kinase-negative PKCalpha elevated TPA-induced PLD activity less significantly than the wild type.	Tetradecanoylphorbol Acetate	38-41	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	50-53
12074591-5	2002	Expression of PKCbetaII and the kinase-negative PKCbetaII enhanced TPA-stimulated PLD activity moderately in MeWo cell line, in which PKCbetaII is absent.	Tetradecanoylphorbol Acetate	67-70	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	82-85
12074591-6	2002	Furthermore, the TPA treatment increased the association of PKCalpha, PKCbetaII, and their kinase-negative mutants with PLD1 in melanoma cells.	Tetradecanoylphorbol Acetate	17-20	protein kinase C alpha	Homo sapiens	60-68
12074591-6	2002	Furthermore, the TPA treatment increased the association of PKCalpha, PKCbetaII, and their kinase-negative mutants with PLD1 in melanoma cells.	Tetradecanoylphorbol Acetate	17-20	phospholipase D1	Homo sapiens	120-124
11940578-6	2002	Dominant negative c-Raf expression or a MEK1/2 inhibitor (U0126) treatment showed a profound blocking effect only on the TPA-stimulated phosphorylation of S6K1 and mTOR.	Tetradecanoylphorbol Acetate	121-124	mechanistic target of rapamycin kinase	Homo sapiens	164-168
11940578-7	2002	Whereas p38 MAPK inhibitors exhibited only partial effect, MAPK-phosphatase-3 expression significantly blocked the TPA-stimulated S6K1 and mTOR phosphorylation.	Tetradecanoylphorbol Acetate	115-118	mechanistic target of rapamycin kinase	Homo sapiens	139-143
12136269-5	2002	The effects of ANGII were blunted by the protein kinase C (PKC) inhibitor bisindolylmaleimide I and mimicked by the PKC activator phorbol 12-myristate-13-acetate (PMA) (EC(50) 10 nmol/l).	Tetradecanoylphorbol Acetate	130-161	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	15-20
12136269-5	2002	The effects of ANGII were blunted by the protein kinase C (PKC) inhibitor bisindolylmaleimide I and mimicked by the PKC activator phorbol 12-myristate-13-acetate (PMA) (EC(50) 10 nmol/l).	Tetradecanoylphorbol Acetate	163-166	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	15-20
11956220-10	2002	Co-transfection of the MAO B promoter with dominant negative forms of Ras, Raf-1, MEKK1, MEK1, MEK3, MEK7, ERK2, JNK1, and p38/RK inhibit the PMA-dependent activation of the MAO B promoter.	Tetradecanoylphorbol Acetate	142-145	mitogen-activated protein kinase 8	Homo sapiens	113-117
21324286-9	2002	TPA was sensitive for the diagnosis of lung cancer and the sensitivity was from 69.2% to 87.5%, but the specificity was low (29.3%); the specificity of Cyfra 21.1 was 97.6%, but the sensitivity was low (12.5%-35.9%); the sensitivity (75.0%) and specificity (82.9%) of NSE were high for SCLC.	Tetradecanoylphorbol Acetate	0-3	enolase 2	Homo sapiens	268-271
12084931-2	2002	Here, we report that pro-uPA (or uPA) inhibits HIV-1 expression in U937-derived chronically infected promonocytic U1 cells stimulated with phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	139-170	plasminogen activator, urokinase	Homo sapiens	25-28
12084931-2	2002	Here, we report that pro-uPA (or uPA) inhibits HIV-1 expression in U937-derived chronically infected promonocytic U1 cells stimulated with phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	139-170	plasminogen activator, urokinase	Homo sapiens	33-36
12084931-2	2002	Here, we report that pro-uPA (or uPA) inhibits HIV-1 expression in U937-derived chronically infected promonocytic U1 cells stimulated with phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	172-175	plasminogen activator, urokinase	Homo sapiens	25-28
12084931-2	2002	Here, we report that pro-uPA (or uPA) inhibits HIV-1 expression in U937-derived chronically infected promonocytic U1 cells stimulated with phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	172-175	plasminogen activator, urokinase	Homo sapiens	33-36
12082614-5	2002	Glucocorticoids, which exhibit potent anti-inflammatory and anti-tumor promoting activities repressed TPA-mediated S100A8 and S100A9 induction in wild type, but not in c-fos(-/-) mice, thus identifying both genes as the first examples of AP-1 target genes whose repression of TPA-induced transcription by glucocorticoids depends on c-Fos.	Tetradecanoylphorbol Acetate	102-105	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	115-121
12110373-9	2002	Such a delocalization of Cx43 proteins was not observed when TPA was coincubated with the flavonoids, (-)-epicatechin or genistein.	Tetradecanoylphorbol Acetate	61-64	gap junction protein, alpha 1	Rattus norvegicus	25-29
12036883-6	2002	Treatment with rapamycin blocked IL-2 production after activation of human peripheral blood T cells with phorbol ester (PMA) and anti-CD28 (CsA-resistant pathway), whereas this drug did not have any effect on PMA plus ionomycin stimulation (CsA-sensitive pathway).	Tetradecanoylphorbol Acetate	120-123	interleukin 2	Homo sapiens	33-37
12110373-10	2002	It is concluded that TPA affects Cx43 trafficking between cellular compartments, and that this effect is counteracted by (-)-epicatechin or genistein.	Tetradecanoylphorbol Acetate	21-24	gap junction protein, alpha 1	Rattus norvegicus	33-37
11934895-5	2002	In transient transfection assay, expression of COUP-TF strongly inhibited tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 transactivation activity and transactivation of c-Jun/c-Fos in both a trans-RA-dependent and -independent manner.	Tetradecanoylphorbol Acetate	89-125	nuclear receptor subfamily 2 group F member 1	Homo sapiens	47-54
12191496-3	2002	Here we report that secretion and expression of HGF in U87 astrocytoma is increased by a PKC activator, PMA, an effect which is abolished by a PKC inhibitor, Go6976, specific for PKCalpha and PKCbeta1.	Tetradecanoylphorbol Acetate	104-107	protein kinase C alpha	Homo sapiens	89-92
12191496-3	2002	Here we report that secretion and expression of HGF in U87 astrocytoma is increased by a PKC activator, PMA, an effect which is abolished by a PKC inhibitor, Go6976, specific for PKCalpha and PKCbeta1.	Tetradecanoylphorbol Acetate	104-107	protein kinase C alpha	Homo sapiens	143-146
12191496-3	2002	Here we report that secretion and expression of HGF in U87 astrocytoma is increased by a PKC activator, PMA, an effect which is abolished by a PKC inhibitor, Go6976, specific for PKCalpha and PKCbeta1.	Tetradecanoylphorbol Acetate	104-107	protein kinase C alpha	Homo sapiens	179-187
12191496-6	2002	Accordingly, PMA induced rapid phosphorylation of MEK substrate, i.e. Erk1/2 (p42/44 MAPK).	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase kinase 7	Homo sapiens	50-53
12191496-6	2002	Accordingly, PMA induced rapid phosphorylation of MEK substrate, i.e. Erk1/2 (p42/44 MAPK).	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 3	Homo sapiens	70-76
12191496-7	2002	In addition, such effect of PKC is Ras-dependent as specific Ras inhibitor L-744,832 attenuated both PMA mediated induction of Erk 1/2 phosphorylation as well as HGF secretion.	Tetradecanoylphorbol Acetate	101-104	protein kinase C alpha	Homo sapiens	28-31
12191496-7	2002	In addition, such effect of PKC is Ras-dependent as specific Ras inhibitor L-744,832 attenuated both PMA mediated induction of Erk 1/2 phosphorylation as well as HGF secretion.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase 3	Homo sapiens	127-134
11934895-7	2002	Stable expression of COUP-TF in COUP-TF-negative MDA-MB231 breast cancer cells restored the ability of trans-RA to inhibit 12-O-tetradecanoylphorbol-13-acetate-induced c-Jun expression.	Tetradecanoylphorbol Acetate	123-159	nuclear receptor subfamily 2 group F member 1	Homo sapiens	21-28
11934895-7	2002	Stable expression of COUP-TF in COUP-TF-negative MDA-MB231 breast cancer cells restored the ability of trans-RA to inhibit 12-O-tetradecanoylphorbol-13-acetate-induced c-Jun expression.	Tetradecanoylphorbol Acetate	123-159	nuclear receptor subfamily 2 group F member 1	Homo sapiens	32-39
11925438-7	2002	In addition, we show that tyrosine phosphorylation of p190RhoGAP is increased upon 12-O-tetradecanoylphorbol-13-acetate stimulation, directly linking Src activation to a decrease in RhoA activity.	Tetradecanoylphorbol Acetate	83-119	Rho GTPase activating protein 35	Rattus norvegicus	54-64
12046067-0	2002	Induction of apoptosis by TPA and VP-16 is through translocation of TR3.	Tetradecanoylphorbol Acetate	26-29	thioredoxin reductase 2	Homo sapiens	68-71
12093473-5	2002	The zymosan-induced increase in iPLA2 activity was suppressed by pretreatment with 4beta-phorbol 12-myristate 13-acetate for 10 hr, by which PKCalpha and PKCdelta, but not PKCbeta and PKCepsilon, were depleted, and by Go6976, a PKCalpha inhibitor, but not rottlerin, a PKCdelta inhibitor.	Tetradecanoylphorbol Acetate	83-120	protein kinase C, alpha	Mus musculus	141-149
12093473-5	2002	The zymosan-induced increase in iPLA2 activity was suppressed by pretreatment with 4beta-phorbol 12-myristate 13-acetate for 10 hr, by which PKCalpha and PKCdelta, but not PKCbeta and PKCepsilon, were depleted, and by Go6976, a PKCalpha inhibitor, but not rottlerin, a PKCdelta inhibitor.	Tetradecanoylphorbol Acetate	83-120	protein kinase C, alpha	Mus musculus	228-236
12123542-3	2002	RESULTS: Transient transfection of RARbeta expression vector into MKN-45 cells resulted in the RARbeta concentration dependent repression of AP-1 activity induced by 12-o-tetradecanoylphorbol-13-acetate (TPA), regardless of the presence of ATRA.	Tetradecanoylphorbol Acetate	166-202	retinoic acid receptor beta	Homo sapiens	35-42
12123542-3	2002	RESULTS: Transient transfection of RARbeta expression vector into MKN-45 cells resulted in the RARbeta concentration dependent repression of AP-1 activity induced by 12-o-tetradecanoylphorbol-13-acetate (TPA), regardless of the presence of ATRA.	Tetradecanoylphorbol Acetate	166-202	retinoic acid receptor beta	Homo sapiens	95-102
12123542-3	2002	RESULTS: Transient transfection of RARbeta expression vector into MKN-45 cells resulted in the RARbeta concentration dependent repression of AP-1 activity induced by 12-o-tetradecanoylphorbol-13-acetate (TPA), regardless of the presence of ATRA.	Tetradecanoylphorbol Acetate	166-202	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	141-145
12123542-3	2002	RESULTS: Transient transfection of RARbeta expression vector into MKN-45 cells resulted in the RARbeta concentration dependent repression of AP-1 activity induced by 12-o-tetradecanoylphorbol-13-acetate (TPA), regardless of the presence of ATRA.	Tetradecanoylphorbol Acetate	204-207	retinoic acid receptor beta	Homo sapiens	35-42
12123542-3	2002	RESULTS: Transient transfection of RARbeta expression vector into MKN-45 cells resulted in the RARbeta concentration dependent repression of AP-1 activity induced by 12-o-tetradecanoylphorbol-13-acetate (TPA), regardless of the presence of ATRA.	Tetradecanoylphorbol Acetate	204-207	retinoic acid receptor beta	Homo sapiens	95-102
12123542-3	2002	RESULTS: Transient transfection of RARbeta expression vector into MKN-45 cells resulted in the RARbeta concentration dependent repression of AP-1 activity induced by 12-o-tetradecanoylphorbol-13-acetate (TPA), regardless of the presence of ATRA.	Tetradecanoylphorbol Acetate	204-207	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	141-145
12113473-4	2002	Overexpression of KLF5 leads to an increase in the TPA response from VLTRE, a TPA-inducible enhancer element that shows keratinocyte specificity with respect to Rel/NF-kappaB binding.	Tetradecanoylphorbol Acetate	51-54	nuclear factor kappa B subunit 1	Homo sapiens	165-174
12023342-2	2002	The in vitro expression of 4-1BB (CD137) is induced following activation of T cells with various stimuli, including anti-TCR mAbs, lectins, and a combination of PMA and ionomycin.	Tetradecanoylphorbol Acetate	161-164	tumor necrosis factor receptor superfamily, member 9	Mus musculus	27-32
12023342-2	2002	The in vitro expression of 4-1BB (CD137) is induced following activation of T cells with various stimuli, including anti-TCR mAbs, lectins, and a combination of PMA and ionomycin.	Tetradecanoylphorbol Acetate	161-164	tumor necrosis factor receptor superfamily, member 9	Mus musculus	34-39
12021387-3	2002	The phorbol ester phorbol 12-myristate 13-acetate (PMA) stimulated pS2 expression in both HepER3 and the parental, non-ER-expressing HepG2 cells, although its activity was substantially less in HepG2 cells.	Tetradecanoylphorbol Acetate	18-49	trefoil factor 1	Homo sapiens	67-70
12021387-3	2002	The phorbol ester phorbol 12-myristate 13-acetate (PMA) stimulated pS2 expression in both HepER3 and the parental, non-ER-expressing HepG2 cells, although its activity was substantially less in HepG2 cells.	Tetradecanoylphorbol Acetate	51-54	trefoil factor 1	Homo sapiens	67-70
12046067-8	2002	At the same time, TPA and VP-16 also up-regulated expression level of TR3 mRNA in MGC80-3 cells that expressed TR3 mRNA.	Tetradecanoylphorbol Acetate	18-21	thioredoxin reductase 2	Homo sapiens	70-73
12046067-8	2002	At the same time, TPA and VP-16 also up-regulated expression level of TR3 mRNA in MGC80-3 cells that expressed TR3 mRNA.	Tetradecanoylphorbol Acetate	18-21	thioredoxin reductase 2	Homo sapiens	111-114
12046067-11	2002	In addition, TPA and VP-16-induced apoptosis involved in translocation of TR3.	Tetradecanoylphorbol Acetate	13-16	thioredoxin reductase 2	Homo sapiens	74-77
12046067-12	2002	In MGC80-3 cells, TR3 localized concentrative in nucleus, after treatment of cells with TPA and VP-16, TR3 translocated from nucleus to cytosol obviously.	Tetradecanoylphorbol Acetate	88-91	thioredoxin reductase 2	Homo sapiens	18-21
12044881-2	2002	In order to assess whether these PLA(2) isoforms are active, we labeled Jurkat T-cells with [(3)H]arachidonic acid ([(3)H]AA) and determined its release into the extracellular medium in the presence of phorbol 12-myristate 13-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	202-233	phospholipase A2 group IB	Homo sapiens	33-39
12093473-5	2002	The zymosan-induced increase in iPLA2 activity was suppressed by pretreatment with 4beta-phorbol 12-myristate 13-acetate for 10 hr, by which PKCalpha and PKCdelta, but not PKCbeta and PKCepsilon, were depleted, and by Go6976, a PKCalpha inhibitor, but not rottlerin, a PKCdelta inhibitor.	Tetradecanoylphorbol Acetate	83-120	phospholipase A2, group VI	Mus musculus	32-37
12059989-9	2002	Phorbol 12-myristate 13-acetate (1 micromol L(-1); positive control) increased membrane binding of alpha-PKC by 34% in Ntcp-transfected and by 37% in sham-transfected cells.	Tetradecanoylphorbol Acetate	0-31	solute carrier family 10 member 1	Homo sapiens	119-123
12039887-13	2002	PMA phosphorylated both p38 and p44/42 MAPK.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	24-27
12021392-0	2002	Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways.	Tetradecanoylphorbol Acetate	70-101	tumor necrosis factor	Homo sapiens	169-190
18759046-3	2002	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in the translocation of PKCalpha from both mitochondria and cytosol to nucleus as clearly shown by laserscanningconfocal microscopy, while the protein level of PKCalpha was not changed by TPA treatment as detected by Western blot.	Tetradecanoylphorbol Acetate	24-60	protein kinase C alpha	Homo sapiens	100-108
18759046-3	2002	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in the translocation of PKCalpha from both mitochondria and cytosol to nucleus as clearly shown by laserscanningconfocal microscopy, while the protein level of PKCalpha was not changed by TPA treatment as detected by Western blot.	Tetradecanoylphorbol Acetate	24-60	protein kinase C alpha	Homo sapiens	236-244
18759046-3	2002	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in the translocation of PKCalpha from both mitochondria and cytosol to nucleus as clearly shown by laserscanningconfocal microscopy, while the protein level of PKCalpha was not changed by TPA treatment as detected by Western blot.	Tetradecanoylphorbol Acetate	62-65	protein kinase C alpha	Homo sapiens	100-108
18759046-3	2002	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in the translocation of PKCalpha from both mitochondria and cytosol to nucleus as clearly shown by laserscanningconfocal microscopy, while the protein level of PKCalpha was not changed by TPA treatment as detected by Western blot.	Tetradecanoylphorbol Acetate	62-65	protein kinase C alpha	Homo sapiens	236-244
18759046-3	2002	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in the translocation of PKCalpha from both mitochondria and cytosol to nucleus as clearly shown by laserscanningconfocal microscopy, while the protein level of PKCalpha was not changed by TPA treatment as detected by Western blot.	Tetradecanoylphorbol Acetate	264-267	protein kinase C alpha	Homo sapiens	100-108
18759046-4	2002	The results also revealed that TPA-induced translocation of PKCalpha was in close association with apoptosis induction, and such association was further affirmed by other experiments where various apoptotic stimuli and specific inhibitors of PKC were used.	Tetradecanoylphorbol Acetate	31-34	protein kinase C alpha	Homo sapiens	60-68
18759046-4	2002	The results also revealed that TPA-induced translocation of PKCalpha was in close association with apoptosis induction, and such association was further affirmed by other experiments where various apoptotic stimuli and specific inhibitors of PKC were used.	Tetradecanoylphorbol Acetate	31-34	protein kinase C alpha	Homo sapiens	60-63
12046067-12	2002	In MGC80-3 cells, TR3 localized concentrative in nucleus, after treatment of cells with TPA and VP-16, TR3 translocated from nucleus to cytosol obviously.	Tetradecanoylphorbol Acetate	88-91	thioredoxin reductase 2	Homo sapiens	103-106
12046067-14	2002	CONCLUSION: Induction of apoptosis by TPA and VP-16 is through induction of TR3 expression and translocation of TR3 from nucleus to cytosol, which may be a novel signal pathway for TR3, and represent the new biological function of TR3 to exert its effect on apoptosis in gastric cancer cells.	Tetradecanoylphorbol Acetate	38-41	thioredoxin reductase 2	Homo sapiens	76-79
12046067-14	2002	CONCLUSION: Induction of apoptosis by TPA and VP-16 is through induction of TR3 expression and translocation of TR3 from nucleus to cytosol, which may be a novel signal pathway for TR3, and represent the new biological function of TR3 to exert its effect on apoptosis in gastric cancer cells.	Tetradecanoylphorbol Acetate	38-41	thioredoxin reductase 2	Homo sapiens	112-115
12046067-7	2002	RESULTS: Treatment of MGC80-3 cells with TPA and VP-16 resulted in apoptosis, accompanied by the repression of Bcl-2 protein in a time-dependent manner.	Tetradecanoylphorbol Acetate	41-44	BCL2 apoptosis regulator	Homo sapiens	111-116
12046067-14	2002	CONCLUSION: Induction of apoptosis by TPA and VP-16 is through induction of TR3 expression and translocation of TR3 from nucleus to cytosol, which may be a novel signal pathway for TR3, and represent the new biological function of TR3 to exert its effect on apoptosis in gastric cancer cells.	Tetradecanoylphorbol Acetate	38-41	thioredoxin reductase 2	Homo sapiens	112-115
12046067-14	2002	CONCLUSION: Induction of apoptosis by TPA and VP-16 is through induction of TR3 expression and translocation of TR3 from nucleus to cytosol, which may be a novel signal pathway for TR3, and represent the new biological function of TR3 to exert its effect on apoptosis in gastric cancer cells.	Tetradecanoylphorbol Acetate	38-41	thioredoxin reductase 2	Homo sapiens	112-115
12039800-10	2002	Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate reduced junctional conductance in cells expressing Cx43, Cx45, or both connexins, but it reduced the extent of neurobiotin transfer only in HeLa-Cx43(His)(6) and HeLa-Cx43(His)(6)/Cx45 cells but not in the HeLa-Cx45 cells.	Tetradecanoylphorbol Acetate	46-82	gap junction protein gamma 1	Homo sapiens	140-144
12039800-10	2002	Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate reduced junctional conductance in cells expressing Cx43, Cx45, or both connexins, but it reduced the extent of neurobiotin transfer only in HeLa-Cx43(His)(6) and HeLa-Cx43(His)(6)/Cx45 cells but not in the HeLa-Cx45 cells.	Tetradecanoylphorbol Acetate	46-82	gap junction protein gamma 1	Homo sapiens	263-267
12039800-10	2002	Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate reduced junctional conductance in cells expressing Cx43, Cx45, or both connexins, but it reduced the extent of neurobiotin transfer only in HeLa-Cx43(His)(6) and HeLa-Cx43(His)(6)/Cx45 cells but not in the HeLa-Cx45 cells.	Tetradecanoylphorbol Acetate	46-82	gap junction protein gamma 1	Homo sapiens	263-267
12032821-1	2002	Previous studies in our laboratories demonstrated that overexpression of manganese superoxide dismutase (MnSOD) suppressed both the incidence and multiplicity of papillomas in a DMBA/TPA multi-stage skin carcinogenesis model.	Tetradecanoylphorbol Acetate	183-186	superoxide dismutase 2, mitochondrial	Mus musculus	73-103
12297018-3	2002	In this study, we have found that curcumin inhibits the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced nuclear factor kB (NF-kappaB) activation by preventing the degradation of the inhibitory protein IkBalpa; and the subsequent translocation of the p65 subunit in cultured human promyelocytic leukemia (HL-60) cells.	Tetradecanoylphorbol Acetate	56-92	nuclear factor kappa B subunit 1	Homo sapiens	126-135
12042657-4	2002	The effect of CI on induction of CD154 expression was studied by stimulating lymphocytes with phorbol 12-myristate 13-acetate (PMA) and ionomycin or with allogeneic monocyte-derived mature dendritic cells.	Tetradecanoylphorbol Acetate	94-125	CD40 ligand	Homo sapiens	33-38
12297018-3	2002	In this study, we have found that curcumin inhibits the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced nuclear factor kB (NF-kappaB) activation by preventing the degradation of the inhibitory protein IkBalpa; and the subsequent translocation of the p65 subunit in cultured human promyelocytic leukemia (HL-60) cells.	Tetradecanoylphorbol Acetate	94-97	nuclear factor kappa B subunit 1	Homo sapiens	126-135
12297018-4	2002	Alternatively, curcumin repressed the TPA-induced activation of NF-kappaB through direct interruption of the binding of NF-kappaB to its consensus DNA sequences.	Tetradecanoylphorbol Acetate	38-41	nuclear factor kappa B subunit 1	Homo sapiens	64-73
12297018-4	2002	Alternatively, curcumin repressed the TPA-induced activation of NF-kappaB through direct interruption of the binding of NF-kappaB to its consensus DNA sequences.	Tetradecanoylphorbol Acetate	38-41	nuclear factor kappa B subunit 1	Homo sapiens	120-129
12297018-5	2002	Likewise, the TPA-induced DNA binding of the activator protein-1 (AP-1) was inhibited by curcumin pretreatment.	Tetradecanoylphorbol Acetate	14-17	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-64
12297018-5	2002	Likewise, the TPA-induced DNA binding of the activator protein-1 (AP-1) was inhibited by curcumin pretreatment.	Tetradecanoylphorbol Acetate	14-17	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-70
12032821-1	2002	Previous studies in our laboratories demonstrated that overexpression of manganese superoxide dismutase (MnSOD) suppressed both the incidence and multiplicity of papillomas in a DMBA/TPA multi-stage skin carcinogenesis model.	Tetradecanoylphorbol Acetate	183-186	superoxide dismutase 2, mitochondrial	Mus musculus	105-110
12032821-3	2002	In the present study, we report that reduction of MnSOD by heterozygous knockout of the MnSOD gene (Sod2 -/+, MnSOD KO) increased the levels of oxidative damage proteins and the activity of AP-1 following TPA treatment.	Tetradecanoylphorbol Acetate	205-208	superoxide dismutase 2, mitochondrial	Mus musculus	50-55
12032821-3	2002	In the present study, we report that reduction of MnSOD by heterozygous knockout of the MnSOD gene (Sod2 -/+, MnSOD KO) increased the levels of oxidative damage proteins and the activity of AP-1 following TPA treatment.	Tetradecanoylphorbol Acetate	205-208	superoxide dismutase 2, mitochondrial	Mus musculus	88-93
12032821-3	2002	In the present study, we report that reduction of MnSOD by heterozygous knockout of the MnSOD gene (Sod2 -/+, MnSOD KO) increased the levels of oxidative damage proteins and the activity of AP-1 following TPA treatment.	Tetradecanoylphorbol Acetate	205-208	superoxide dismutase 2, mitochondrial	Mus musculus	100-104
12032821-3	2002	In the present study, we report that reduction of MnSOD by heterozygous knockout of the MnSOD gene (Sod2 -/+, MnSOD KO) increased the levels of oxidative damage proteins and the activity of AP-1 following TPA treatment.	Tetradecanoylphorbol Acetate	205-208	superoxide dismutase 2, mitochondrial	Mus musculus	88-93
12032821-12	2002	Taken together, these results suggest that: (1) MnSOD deficiency enhanced TPA-induced oxidative stress and AP-1 and p53 levels, consistent with the increase in both proliferation and apoptosis events in the MnSOD KO mice, and (2) increased apoptosis may negate increased proliferation in the MnSOD deficient mice during an early stage of tumor development.	Tetradecanoylphorbol Acetate	74-77	superoxide dismutase 2, mitochondrial	Mus musculus	48-53
11988078-8	2002	The cirazoline-stimulated (alpha(1)-adrenergic) CREB phosphorylation was inhibited by a desensitizing pretreatment with PMA, demonstrating that the alpha(1)-stimulation was mediated via protein kinase C activation; neither Src nor extracellular-signal-regulated kinases 1 and 2 activation was involved in the signalling process.	Tetradecanoylphorbol Acetate	120-123	cAMP responsive element binding protein 1	Mus musculus	48-52
12054499-4	2002	Signaling cascade studies indicated that both FGF-2 and TPA induced Ras activation, c-Raf phosphorylation, mitogen-activated protein kinase/ERK kinase (MEK(1/2)) phosphorylation, and extracellular signal-regulated kinase (ERK(1/2)) phosphorylation.	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase 3	Homo sapiens	183-229
12054499-6	2002	A pan-protein kinase C (PKC) inhibitor, GF109203X, was found to totally abolish the FGF-2- and TPA-induced MMP-9 secretion and ERK(1/2) phosphorylation.	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 3	Homo sapiens	127-134
12054499-8	2002	These results demonstrated that FGF-2 and TPA induce MMP-9 secretion in MCF-7 cells mainly through PKC-dependent activation of the Ras/ERK(1/2) signaling pathway.	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 3	Homo sapiens	135-142
11884403-4	2002	Phorbol myristate acetate induced a dramatic increase of both IL-6R shedding (i.e. the production of sIL-6R) and IL-6 release in osteoblast cultures, but the cell surface expression of gp130 remained unchanged.	Tetradecanoylphorbol Acetate	0-25	interleukin 6 receptor	Homo sapiens	62-67
11884403-4	2002	Phorbol myristate acetate induced a dramatic increase of both IL-6R shedding (i.e. the production of sIL-6R) and IL-6 release in osteoblast cultures, but the cell surface expression of gp130 remained unchanged.	Tetradecanoylphorbol Acetate	0-25	interleukin 6	Homo sapiens	62-66
11884403-7	2002	Protein kinase C inhibitors blocked phorbol myristate acetate-induced and spontaneous shedding of IL-6R resulting in the absence of sIL-6R in the culture medium, which in turn also prevented the activation of gp130.	Tetradecanoylphorbol Acetate	36-61	interleukin 6 receptor	Homo sapiens	98-103
11825899-3	2002	Treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) caused an increase in the activity of the human IGF-I gene major promoter in HepG2 cells.	Tetradecanoylphorbol Acetate	15-51	insulin like growth factor 1	Homo sapiens	106-111
11825899-3	2002	Treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) caused an increase in the activity of the human IGF-I gene major promoter in HepG2 cells.	Tetradecanoylphorbol Acetate	53-56	insulin like growth factor 1	Homo sapiens	106-111
11825899-4	2002	A CCAAT/enhancer-binding protein (C/EBP) binding site located at +22 to +30 was bound by C/EBP beta in a TPA-dependent manner and was solely responsible for the TPA responsiveness.	Tetradecanoylphorbol Acetate	105-108	CCAAT enhancer binding protein alpha	Homo sapiens	2-32
11825899-4	2002	A CCAAT/enhancer-binding protein (C/EBP) binding site located at +22 to +30 was bound by C/EBP beta in a TPA-dependent manner and was solely responsible for the TPA responsiveness.	Tetradecanoylphorbol Acetate	105-108	CCAAT enhancer binding protein alpha	Homo sapiens	34-39
11825899-4	2002	A CCAAT/enhancer-binding protein (C/EBP) binding site located at +22 to +30 was bound by C/EBP beta in a TPA-dependent manner and was solely responsible for the TPA responsiveness.	Tetradecanoylphorbol Acetate	161-164	CCAAT enhancer binding protein alpha	Homo sapiens	2-32
11825899-4	2002	A CCAAT/enhancer-binding protein (C/EBP) binding site located at +22 to +30 was bound by C/EBP beta in a TPA-dependent manner and was solely responsible for the TPA responsiveness.	Tetradecanoylphorbol Acetate	161-164	CCAAT enhancer binding protein alpha	Homo sapiens	34-39
12023021-4	2002	By prednisolone or phorbol myristate acetate treatment, EC-SOD levels were correlated negatively with levels of IL-6 and IL-8.	Tetradecanoylphorbol Acetate	19-44	superoxide dismutase 3	Homo sapiens	56-62
12023021-4	2002	By prednisolone or phorbol myristate acetate treatment, EC-SOD levels were correlated negatively with levels of IL-6 and IL-8.	Tetradecanoylphorbol Acetate	19-44	interleukin 6	Homo sapiens	112-116
12023021-4	2002	By prednisolone or phorbol myristate acetate treatment, EC-SOD levels were correlated negatively with levels of IL-6 and IL-8.	Tetradecanoylphorbol Acetate	19-44	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
12054499-0	2002	FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway.	Tetradecanoylphorbol Acetate	10-13	mitogen-activated protein kinase 1	Homo sapiens	107-110
11986211-3	2002	In the presence of serum and phorbol 12-myristate 13-acetate (PMA), a PKC activator, cells exhibited full megakaryocytic differentiation, manifested by adhesion, shape change, increased cell size, polyploidy, PPF, and expression of CD41(+), CD61(+), and CD62P(+).	Tetradecanoylphorbol Acetate	29-60	integrin subunit beta 3	Homo sapiens	241-245
11986211-3	2002	In the presence of serum and phorbol 12-myristate 13-acetate (PMA), a PKC activator, cells exhibited full megakaryocytic differentiation, manifested by adhesion, shape change, increased cell size, polyploidy, PPF, and expression of CD41(+), CD61(+), and CD62P(+).	Tetradecanoylphorbol Acetate	62-65	integrin subunit beta 3	Homo sapiens	241-245
11877397-3	2002	Here we report the stimulation of IRF-7 expression by 12-O-tetradecanoylphorbol-13-acetate (TPA) and tumor necrosis factor alpha (TNFalpha) in human peripheral blood monocytes.	Tetradecanoylphorbol Acetate	54-90	interferon regulatory factor 7	Homo sapiens	34-39
11877397-3	2002	Here we report the stimulation of IRF-7 expression by 12-O-tetradecanoylphorbol-13-acetate (TPA) and tumor necrosis factor alpha (TNFalpha) in human peripheral blood monocytes.	Tetradecanoylphorbol Acetate	92-95	interferon regulatory factor 7	Homo sapiens	34-39
11877397-4	2002	Using promoter analysis in combination with electrophoretic mobility shift assays, we have demonstrated that an NFkappaB site located next to the TATA box, binds p50 and p65 heterodimer and is required for the induction of the IRF-7 gene by TPA and TNFalpha.	Tetradecanoylphorbol Acetate	241-244	nuclear factor kappa B subunit 1	Homo sapiens	112-120
11877397-4	2002	Using promoter analysis in combination with electrophoretic mobility shift assays, we have demonstrated that an NFkappaB site located next to the TATA box, binds p50 and p65 heterodimer and is required for the induction of the IRF-7 gene by TPA and TNFalpha.	Tetradecanoylphorbol Acetate	241-244	nuclear factor kappa B subunit 1	Homo sapiens	162-165
11877397-4	2002	Using promoter analysis in combination with electrophoretic mobility shift assays, we have demonstrated that an NFkappaB site located next to the TATA box, binds p50 and p65 heterodimer and is required for the induction of the IRF-7 gene by TPA and TNFalpha.	Tetradecanoylphorbol Acetate	241-244	interferon regulatory factor 7	Homo sapiens	227-232
11877397-4	2002	Using promoter analysis in combination with electrophoretic mobility shift assays, we have demonstrated that an NFkappaB site located next to the TATA box, binds p50 and p65 heterodimer and is required for the induction of the IRF-7 gene by TPA and TNFalpha.	Tetradecanoylphorbol Acetate	241-244	tumor necrosis factor	Homo sapiens	249-257
12082637-4	2002	A RNase-protection analysis showed that PMA stimulated the expression of several known anti-apoptotic genes (TRAF1, TRAF4, c-IAP-1, c-IAP-2, Bfl-1, Bcl-xl).	Tetradecanoylphorbol Acetate	40-43	TNF receptor associated factor 1	Homo sapiens	109-114
12082637-4	2002	A RNase-protection analysis showed that PMA stimulated the expression of several known anti-apoptotic genes (TRAF1, TRAF4, c-IAP-1, c-IAP-2, Bfl-1, Bcl-xl).	Tetradecanoylphorbol Acetate	40-43	BCL2 related protein A1	Homo sapiens	141-146
12082637-4	2002	A RNase-protection analysis showed that PMA stimulated the expression of several known anti-apoptotic genes (TRAF1, TRAF4, c-IAP-1, c-IAP-2, Bfl-1, Bcl-xl).	Tetradecanoylphorbol Acetate	40-43	BCL2 like 1	Homo sapiens	148-154
11825899-5	2002	This increase in C/EBP beta activity occurs through transcriptional and posttranslational regulation, and the latter is mediated by activation of p90 ribosomal S6 kinase (RSK): co-expression of dominant negative RSK abolished the TPA-responsive and C/EBP beta-dependent transactivation.	Tetradecanoylphorbol Acetate	230-233	ribosomal protein S6 kinase A2	Homo sapiens	171-174
11825899-5	2002	This increase in C/EBP beta activity occurs through transcriptional and posttranslational regulation, and the latter is mediated by activation of p90 ribosomal S6 kinase (RSK): co-expression of dominant negative RSK abolished the TPA-responsive and C/EBP beta-dependent transactivation.	Tetradecanoylphorbol Acetate	230-233	ribosomal protein S6 kinase A2	Homo sapiens	212-215
11825899-6	2002	Also, TPA-responsive activation of GAL4-C/EBP beta chimera required the Ser residue known as the RSK target.	Tetradecanoylphorbol Acetate	6-9	ribosomal protein S6 kinase A2	Homo sapiens	97-100
11825899-10	2002	These observations suggest that the increase of C/EBP beta binding to the C/EBP site, which is in part mediated via activation of RSK, can primarily explain the TPA responsiveness of the IGF-I gene promoter.	Tetradecanoylphorbol Acetate	161-164	CCAAT enhancer binding protein alpha	Homo sapiens	48-53
11825899-10	2002	These observations suggest that the increase of C/EBP beta binding to the C/EBP site, which is in part mediated via activation of RSK, can primarily explain the TPA responsiveness of the IGF-I gene promoter.	Tetradecanoylphorbol Acetate	161-164	ribosomal protein S6 kinase A2	Homo sapiens	130-133
11825899-10	2002	These observations suggest that the increase of C/EBP beta binding to the C/EBP site, which is in part mediated via activation of RSK, can primarily explain the TPA responsiveness of the IGF-I gene promoter.	Tetradecanoylphorbol Acetate	161-164	insulin like growth factor 1	Homo sapiens	187-192
11980644-1	2002	Treatment with retinoic acid (RA) or carnosol, two structurally unrelated compounds with anticancer properties, inhibited phorbol ester (PMA)-mediated induction of activator protein-1 (AP-1) activity and cyclooxygenase-2 (COX-2) expression in human mammary epithelial cells.	Tetradecanoylphorbol Acetate	137-140	prostaglandin-endoperoxide synthase 2	Homo sapiens	204-220
12020816-1	2002	The human homologue of yeast NHP2, which is known to be a core protein component of yeast H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), was identified by ODD-PCR as a 313-bp cDNA fragment exhibiting a distinct decrease in its expression level during TPA-induced differentiation of promonocytic U937 into monocytes and macrophages.	Tetradecanoylphorbol Acetate	265-268	snoRNA-binding protein NHP2	Saccharomyces cerevisiae S288C	29-33
11980644-1	2002	Treatment with retinoic acid (RA) or carnosol, two structurally unrelated compounds with anticancer properties, inhibited phorbol ester (PMA)-mediated induction of activator protein-1 (AP-1) activity and cyclooxygenase-2 (COX-2) expression in human mammary epithelial cells.	Tetradecanoylphorbol Acetate	137-140	prostaglandin-endoperoxide synthase 2	Homo sapiens	222-227
11980644-2	2002	The induction of COX-2 transcription by PMA was mediated by increased binding of AP-1 to the cyclic AMP response element (CRE) of the COX-2 promoter.	Tetradecanoylphorbol Acetate	40-43	prostaglandin-endoperoxide synthase 2	Homo sapiens	17-22
11980644-2	2002	The induction of COX-2 transcription by PMA was mediated by increased binding of AP-1 to the cyclic AMP response element (CRE) of the COX-2 promoter.	Tetradecanoylphorbol Acetate	40-43	prostaglandin-endoperoxide synthase 2	Homo sapiens	134-139
11980644-3	2002	Inhibition of the histone acetyltransferase activity of CREB- binding protein (CBP)/p300 blocked the induction of COX-2 by PMA.	Tetradecanoylphorbol Acetate	123-126	CREB binding protein	Homo sapiens	56-77
11980644-3	2002	Inhibition of the histone acetyltransferase activity of CREB- binding protein (CBP)/p300 blocked the induction of COX-2 by PMA.	Tetradecanoylphorbol Acetate	123-126	CREB binding protein	Homo sapiens	79-82
11980644-3	2002	Inhibition of the histone acetyltransferase activity of CREB- binding protein (CBP)/p300 blocked the induction of COX-2 by PMA.	Tetradecanoylphorbol Acetate	123-126	prostaglandin-endoperoxide synthase 2	Homo sapiens	114-119
11980644-10	2002	Overexpressing c-Jun but not CBP/p300 reversed the suppressive effect of carnosol on PMA-mediated stimulation of COX-2 promoter activity.	Tetradecanoylphorbol Acetate	85-88	prostaglandin-endoperoxide synthase 2	Homo sapiens	113-118
11956146-7	2002	Here we demonstrate that calcium influx itself is not sufficient to confer the response, but it is necessary for both 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and GnRH induction of the FSHbeta gene.	Tetradecanoylphorbol Acetate	157-160	follicle stimulating hormone beta	Mus musculus	188-195
11956146-9	2002	Interestingly, GnRH and TPA induce activity of the FSHbeta promoter through different, although possibly overlapping, pools of PKC isoforms.	Tetradecanoylphorbol Acetate	24-27	follicle stimulating hormone beta	Mus musculus	51-58
12222798-1	2002	Changes in urokinase-plasminogen activator (u-PA) and u-PA receptor (u-PAR) expression at the protein and mRNA level in resting neutrophils and in neutrophils activated by phorbol myristate acetate (PMA) were examined.	Tetradecanoylphorbol Acetate	199-202	plasminogen activator, urokinase receptor	Bos taurus	54-67
12222798-1	2002	Changes in urokinase-plasminogen activator (u-PA) and u-PA receptor (u-PAR) expression at the protein and mRNA level in resting neutrophils and in neutrophils activated by phorbol myristate acetate (PMA) were examined.	Tetradecanoylphorbol Acetate	199-202	plasminogen activator, urokinase receptor	Bos taurus	69-74
12222798-1	2002	Changes in urokinase-plasminogen activator (u-PA) and u-PA receptor (u-PAR) expression at the protein and mRNA level in resting neutrophils and in neutrophils activated by phorbol myristate acetate (PMA) were examined.	Tetradecanoylphorbol Acetate	172-197	plasminogen activator, urokinase receptor	Bos taurus	54-67
12222798-1	2002	Changes in urokinase-plasminogen activator (u-PA) and u-PA receptor (u-PAR) expression at the protein and mRNA level in resting neutrophils and in neutrophils activated by phorbol myristate acetate (PMA) were examined.	Tetradecanoylphorbol Acetate	172-197	plasminogen activator, urokinase receptor	Bos taurus	69-74
12222798-11	2002	Thus, PKC plays a role in the modulation of u-PA and u-PAR by PMA in bovine neutrophils.	Tetradecanoylphorbol Acetate	62-65	plasminogen activator, urokinase receptor	Bos taurus	53-58
11961080-5	2002	The IC(50) for IL-5 and IL-13 in TPA/ionomycin-stimulated peripheral blood mononuclear cells (PBMC) is 0.7 +/- 0.1 and 0.5 +/- 0.1 microM, respectively, whereas the IC(50) for IFN-gamma is 2.0 +/- 0.4 microM.	Tetradecanoylphorbol Acetate	33-36	interleukin 13	Homo sapiens	24-29
12065659-2	2002	The up-regulation of endogenous TH protein or a transfected TH promoter-luciferase construct by AII, veratridine, or PMA (but not by forskolin) is abolished by transfection with a dominant negative FGFR1TK-mutant which localizes to the nucleus and plasma membrane, but not by extracellularly acting FGFR1 antagonists suramin and inositolhexakisphosphate (IP6).	Tetradecanoylphorbol Acetate	117-120	tyrosine hydroxylase	Homo sapiens	32-34
12065659-2	2002	The up-regulation of endogenous TH protein or a transfected TH promoter-luciferase construct by AII, veratridine, or PMA (but not by forskolin) is abolished by transfection with a dominant negative FGFR1TK-mutant which localizes to the nucleus and plasma membrane, but not by extracellularly acting FGFR1 antagonists suramin and inositolhexakisphosphate (IP6).	Tetradecanoylphorbol Acetate	117-120	tyrosine hydroxylase	Homo sapiens	60-62
12065659-2	2002	The up-regulation of endogenous TH protein or a transfected TH promoter-luciferase construct by AII, veratridine, or PMA (but not by forskolin) is abolished by transfection with a dominant negative FGFR1TK-mutant which localizes to the nucleus and plasma membrane, but not by extracellularly acting FGFR1 antagonists suramin and inositolhexakisphosphate (IP6).	Tetradecanoylphorbol Acetate	117-120	fibroblast growth factor receptor 1	Homo sapiens	198-203
11815600-1	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA) suppresses the proliferation of the human breast epithelial cell line MCF10A-Neo by initiating proteolytic processes that activate latent transforming growth factor (TGF)-beta in the serum used to supplement culture medium.	Tetradecanoylphorbol Acetate	0-36	plasminogen activator, tissue type	Homo sapiens	38-41
11994530-6	2002	Furthermore, direct activation of reduced nicotinamide adenine dinucleotide phosphate oxidase activity with the ester phorbol 12-myristate 13-acetate resulted in a concentration-dependent loss of cell-associated (3)H-DG, and preincubation of neutrophils with the phosphoinositide 3-kinase inhibitor wortmannin, which abolished both agonist-stimulated superoxide anion generation and degranulation, had no effect on TNFalpha- or fMLP-stimulated (3)H-DG uptake.	Tetradecanoylphorbol Acetate	118-149	tumor necrosis factor	Homo sapiens	415-423
11994530-6	2002	Furthermore, direct activation of reduced nicotinamide adenine dinucleotide phosphate oxidase activity with the ester phorbol 12-myristate 13-acetate resulted in a concentration-dependent loss of cell-associated (3)H-DG, and preincubation of neutrophils with the phosphoinositide 3-kinase inhibitor wortmannin, which abolished both agonist-stimulated superoxide anion generation and degranulation, had no effect on TNFalpha- or fMLP-stimulated (3)H-DG uptake.	Tetradecanoylphorbol Acetate	118-149	formyl peptide receptor 1	Homo sapiens	428-432
12162432-4	2002	TPA and EGF, acting through the MAP kinase pathway, activate AP-1 and subsequently NF-kappaB proteins and downstream transcription processes that are involved in the transformation response in transformation-sensitive (P+) JB6 cells.	Tetradecanoylphorbol Acetate	0-3	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	61-65
11815600-1	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA) suppresses the proliferation of the human breast epithelial cell line MCF10A-Neo by initiating proteolytic processes that activate latent transforming growth factor (TGF)-beta in the serum used to supplement culture medium.	Tetradecanoylphorbol Acetate	0-36	transforming growth factor beta 1	Homo sapiens	209-218
11929788-6	2002	TPA, but not IL-4, induced ERK activation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	27-30
11939791-2	2002	The interaction of the carboxyl-terminal lysine residues of the p11 subunit of AIIt with the lysine-binding kringle domains of plasminogen is believed to play a key role in plasminogen binding and stimulation of the tPA-catalyzed cleavage of plasminogen to plasmin.	Tetradecanoylphorbol Acetate	216-219	S100 calcium binding protein A10	Homo sapiens	64-67
11929788-9	2002	In addition, Akt, a downstream effector of PI3-kinase activity, was phosphorylated by TPA and IL-4 in B-CLL cells, though PI3-kinase had no effect on PKC-dependent phosphorylation of Akt.	Tetradecanoylphorbol Acetate	86-89	AKT serine/threonine kinase 1	Homo sapiens	13-16
11959794-7	2002	Cyclosporine (CsA) and FK-506 inhibited IL-13 synthesis, when cells were stimulated by TPA/ionomycin.	Tetradecanoylphorbol Acetate	87-90	interleukin 13	Homo sapiens	40-45
11821392-5	2002	Treatment with pervanadate or phorbol myristate acetate inhibits PLD more in HEK 293 cells overexpressing alpha-synuclein than in control cells.	Tetradecanoylphorbol Acetate	30-55	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	65-68
11956069-5	2002	The subsequent confirmation of the altered expression levels of the selected genes by semiquantitative reverse transcription-PCR demonstrated that overexpression of the antisense ING1 stimulated expression of 14 genes, which included cyclin B1, 12-O-tetradecanoylphorbol-13-acetate-inducible sequence 11, proto-oncogene DEK, and osteopontin, whereas we have detected transcriptional repression of 5 genes, including TPT1.	Tetradecanoylphorbol Acetate	245-281	DEK proto-oncogene (DNA binding)	Mus musculus	320-323
11944907-4	2002	Genistein inhibited PLD activity with an IC(50) value of 12.2 microM in fMLP- and 107 microM in phorbol myristate acetate (PMA)-stimulated cells.	Tetradecanoylphorbol Acetate	96-121	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	20-23
11944907-4	2002	Genistein inhibited PLD activity with an IC(50) value of 12.2 microM in fMLP- and 107 microM in phorbol myristate acetate (PMA)-stimulated cells.	Tetradecanoylphorbol Acetate	123-126	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	20-23
11959806-4	2002	In whole cell cyclic AMP accumulation studies, activation of PKC either by phorbol 12-myristate 13-acetate (PMA) or by purinoceptor stimulation using uridine 5"-triphosphate (UTP) decreased secretin receptor responsiveness.	Tetradecanoylphorbol Acetate	75-106	secretin receptor	Mus musculus	190-207
12058964-4	2002	TPA stimulated MMP-1, -9 and TIMP-1 mRNA expression in both cell lines.	Tetradecanoylphorbol Acetate	0-3	TIMP metallopeptidase inhibitor 1	Homo sapiens	29-35
11959794-15	2002	MEK inhibitor U0126 inhibited TPA/ionomycin induced IL-13 synthesis very effectively, whereas alpha-CD3/alpha-CD28 stimulated IL-13 induction was resistant to this drug.	Tetradecanoylphorbol Acetate	30-33	mitogen-activated protein kinase kinase 7	Homo sapiens	0-3
11959806-4	2002	In whole cell cyclic AMP accumulation studies, activation of PKC either by phorbol 12-myristate 13-acetate (PMA) or by purinoceptor stimulation using uridine 5"-triphosphate (UTP) decreased secretin receptor responsiveness.	Tetradecanoylphorbol Acetate	108-111	secretin receptor	Mus musculus	190-207
11959794-15	2002	MEK inhibitor U0126 inhibited TPA/ionomycin induced IL-13 synthesis very effectively, whereas alpha-CD3/alpha-CD28 stimulated IL-13 induction was resistant to this drug.	Tetradecanoylphorbol Acetate	30-33	interleukin 13	Homo sapiens	52-57
11901219-6	2002	In this report, we show that TPA activates AP-1 as well as the transcription factor nuclear factor kappaB (NFkappaB) in the mu-opioid receptor expressing neuroblastoma cell line SH SY5Y.	Tetradecanoylphorbol Acetate	29-32	nuclear factor kappa B subunit 1	Homo sapiens	107-115
11938511-4	2002	Suboptimal stimulation with 4 beta-phorbol-12-myristate-13-acetate (PMA) plus particles resulted in a synergistic release of superoxide (O2-), however, and a low-level production of nitric oxide small middle dot by THP-1 macrophages.	Tetradecanoylphorbol Acetate	28-66	GLI family zinc finger 2	Homo sapiens	215-220
11938511-4	2002	Suboptimal stimulation with 4 beta-phorbol-12-myristate-13-acetate (PMA) plus particles resulted in a synergistic release of superoxide (O2-), however, and a low-level production of nitric oxide small middle dot by THP-1 macrophages.	Tetradecanoylphorbol Acetate	68-71	GLI family zinc finger 2	Homo sapiens	215-220
11927660-9	2002	fMetLeuPhe and phorbol 12-myristate 13-acetate stimulated ARNO and cytohesin-1 as well as Arf1 translocation to HL-60 cell membranes.	Tetradecanoylphorbol Acetate	15-46	cytohesin 2	Homo sapiens	58-62
11927660-9	2002	fMetLeuPhe and phorbol 12-myristate 13-acetate stimulated ARNO and cytohesin-1 as well as Arf1 translocation to HL-60 cell membranes.	Tetradecanoylphorbol Acetate	15-46	cytohesin 1	Homo sapiens	67-78
11907165-3	2002	In this study, by using the primary cultures of hypothalamic neurons, we tested the effects of PKC stimulator phorbol ester 4 beta-phorbol 12-myristate-13-acetate (PMA) and PKC inhibitor chelerythrine chloride on ethanol-induced IR-beta-EP release.	Tetradecanoylphorbol Acetate	164-167	protein kinase C alpha	Homo sapiens	95-98
11960350-4	2002	Induction of monocytic differentiation in HL-60 cells by treatment with phorbol 12-myristate 13-acetate (PMA) led to rapid and sustained activation of MEK-1/-2, ERK-1/MAPK and ERK-2/MAPK, while induction of granulocytic differentiation by retinoic acid (RA) caused similar activation of MEK-1/-2 and ERK-2/MAPK, but not ERK-1/MAPK.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase 1	Homo sapiens	300-305
11960350-4	2002	Induction of monocytic differentiation in HL-60 cells by treatment with phorbol 12-myristate 13-acetate (PMA) led to rapid and sustained activation of MEK-1/-2, ERK-1/MAPK and ERK-2/MAPK, while induction of granulocytic differentiation by retinoic acid (RA) caused similar activation of MEK-1/-2 and ERK-2/MAPK, but not ERK-1/MAPK.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase 3	Homo sapiens	320-325
11960350-6	2002	Pretreatment of cells with 5 microM of the MEK-1/-2-specific inhibitor U0126 abrogated PMA- or RA-induced activation of ERK-1/MAPK and ERK-2/MAPK.	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase 3	Homo sapiens	120-125
11960350-6	2002	Pretreatment of cells with 5 microM of the MEK-1/-2-specific inhibitor U0126 abrogated PMA- or RA-induced activation of ERK-1/MAPK and ERK-2/MAPK.	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase 1	Homo sapiens	135-140
11950946-5	2002	Down-regulation of diacylglycerol-sensitive types of protein kinase C (PKC) by pretreatment with phorbol 12-myristate 13-acetate or inhibition with bisindolylmaleimide prevented the DA-mediated increase in Na,K-ATPase activity and exocytosis of Na,K-pumps to the BLM.	Tetradecanoylphorbol Acetate	97-128	protein kinase C alpha	Homo sapiens	71-74
11907233-4	2002	NF-kappaB complexes in the nucleus were increased in A224L-expressing cells compared with control cells upon stimulation with phorbol myristate acetate (PMA) plus ionomycin.	Tetradecanoylphorbol Acetate	126-151	nuclear factor kappa B subunit 1	Homo sapiens	0-9
11907233-4	2002	NF-kappaB complexes in the nucleus were increased in A224L-expressing cells compared with control cells upon stimulation with phorbol myristate acetate (PMA) plus ionomycin.	Tetradecanoylphorbol Acetate	153-156	nuclear factor kappa B subunit 1	Homo sapiens	0-9
11960350-4	2002	Induction of monocytic differentiation in HL-60 cells by treatment with phorbol 12-myristate 13-acetate (PMA) led to rapid and sustained activation of MEK-1/-2, ERK-1/MAPK and ERK-2/MAPK, while induction of granulocytic differentiation by retinoic acid (RA) caused similar activation of MEK-1/-2 and ERK-2/MAPK, but not ERK-1/MAPK.	Tetradecanoylphorbol Acetate	72-103	mitogen-activated protein kinase 3	Homo sapiens	161-166
11960350-4	2002	Induction of monocytic differentiation in HL-60 cells by treatment with phorbol 12-myristate 13-acetate (PMA) led to rapid and sustained activation of MEK-1/-2, ERK-1/MAPK and ERK-2/MAPK, while induction of granulocytic differentiation by retinoic acid (RA) caused similar activation of MEK-1/-2 and ERK-2/MAPK, but not ERK-1/MAPK.	Tetradecanoylphorbol Acetate	72-103	mitogen-activated protein kinase 1	Homo sapiens	176-181
11960350-4	2002	Induction of monocytic differentiation in HL-60 cells by treatment with phorbol 12-myristate 13-acetate (PMA) led to rapid and sustained activation of MEK-1/-2, ERK-1/MAPK and ERK-2/MAPK, while induction of granulocytic differentiation by retinoic acid (RA) caused similar activation of MEK-1/-2 and ERK-2/MAPK, but not ERK-1/MAPK.	Tetradecanoylphorbol Acetate	72-103	mitogen-activated protein kinase 1	Homo sapiens	300-305
11960350-4	2002	Induction of monocytic differentiation in HL-60 cells by treatment with phorbol 12-myristate 13-acetate (PMA) led to rapid and sustained activation of MEK-1/-2, ERK-1/MAPK and ERK-2/MAPK, while induction of granulocytic differentiation by retinoic acid (RA) caused similar activation of MEK-1/-2 and ERK-2/MAPK, but not ERK-1/MAPK.	Tetradecanoylphorbol Acetate	72-103	mitogen-activated protein kinase 3	Homo sapiens	320-325
11960350-4	2002	Induction of monocytic differentiation in HL-60 cells by treatment with phorbol 12-myristate 13-acetate (PMA) led to rapid and sustained activation of MEK-1/-2, ERK-1/MAPK and ERK-2/MAPK, while induction of granulocytic differentiation by retinoic acid (RA) caused similar activation of MEK-1/-2 and ERK-2/MAPK, but not ERK-1/MAPK.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase 3	Homo sapiens	161-166
11960350-4	2002	Induction of monocytic differentiation in HL-60 cells by treatment with phorbol 12-myristate 13-acetate (PMA) led to rapid and sustained activation of MEK-1/-2, ERK-1/MAPK and ERK-2/MAPK, while induction of granulocytic differentiation by retinoic acid (RA) caused similar activation of MEK-1/-2 and ERK-2/MAPK, but not ERK-1/MAPK.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase 1	Homo sapiens	176-181
11884618-5	2002	In several types of mammalian cells, RACK1 interacted with IGF-IR, protein kinase C, and beta1 integrin in response to IGF-I and phorbol 12-myristate 13-acetate stimulation.	Tetradecanoylphorbol Acetate	129-160	insulin like growth factor 1	Homo sapiens	59-64
11799119-5	2002	The TPA-stimulated phosphorylation of all these sites is sensitive to inhibitors of MEK and to the inhibitor of mTOR, rapamycin, indicating that inputs from both mTOR and MEK are required for the regulation of 4E-BP1 phosphorylation by TPA.	Tetradecanoylphorbol Acetate	4-7	mechanistic target of rapamycin kinase	Homo sapiens	162-166
12054913-5	2002	IL-17 also enhanced the IL-6 synthesis stimulated by 12- O -tetradecanoylphorbol-13-acetate, a direct activator of protein kinase C. In addition, IL-17 amplified the IL-6 synthesis induced by ET-1.	Tetradecanoylphorbol Acetate	53-91	interleukin 6	Mus musculus	24-28
11989839-11	2002	PKC inhibitor, however, could abrogate PMA-induced COX-2 gene expression, but it did not block IL-6-induced COX-2 expression.	Tetradecanoylphorbol Acetate	39-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56
11989839-12	2002	CONCLUSIONS: Our data suggest that COX-2 expression in ESCC cells could be upregulated by PMA, PAF, n-BT and IL-6.	Tetradecanoylphorbol Acetate	90-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
11799119-1	2002	The phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent stimulator of Erk, leads to the phosphorylation of 4E-BP1 and its dissociation from eIF4E.	Tetradecanoylphorbol Acetate	19-55	mitogen-activated protein kinase 1	Homo sapiens	86-89
11799119-1	2002	The phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent stimulator of Erk, leads to the phosphorylation of 4E-BP1 and its dissociation from eIF4E.	Tetradecanoylphorbol Acetate	57-60	mitogen-activated protein kinase 1	Homo sapiens	86-89
11799119-5	2002	The TPA-stimulated phosphorylation of all these sites is sensitive to inhibitors of MEK and to the inhibitor of mTOR, rapamycin, indicating that inputs from both mTOR and MEK are required for the regulation of 4E-BP1 phosphorylation by TPA.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase kinase 7	Homo sapiens	84-87
11799119-5	2002	The TPA-stimulated phosphorylation of all these sites is sensitive to inhibitors of MEK and to the inhibitor of mTOR, rapamycin, indicating that inputs from both mTOR and MEK are required for the regulation of 4E-BP1 phosphorylation by TPA.	Tetradecanoylphorbol Acetate	4-7	mechanistic target of rapamycin kinase	Homo sapiens	112-116
11799119-5	2002	The TPA-stimulated phosphorylation of all these sites is sensitive to inhibitors of MEK and to the inhibitor of mTOR, rapamycin, indicating that inputs from both mTOR and MEK are required for the regulation of 4E-BP1 phosphorylation by TPA.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase kinase 7	Homo sapiens	171-174
12039070-9	2002	FLRG promoter activity is significantly augmented by phorbol 12-myristate 13-acetate (PMA) treatment, but not by cAMP stimulation.	Tetradecanoylphorbol Acetate	53-84	follistatin like 3	Homo sapiens	0-4
11948401-9	2002	The transcriptional activities of full-length JunB and full-length Fra-1, but not the transactivation domain fusions, were increased by TPA treatment and suppressed by RA.	Tetradecanoylphorbol Acetate	136-139	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	46-50
12039070-9	2002	FLRG promoter activity is significantly augmented by phorbol 12-myristate 13-acetate (PMA) treatment, but not by cAMP stimulation.	Tetradecanoylphorbol Acetate	86-89	follistatin like 3	Homo sapiens	0-4
12039071-3	2002	The phorbol ester, 1-O-tetradecanoyl phorbol-13-acetate (TPA; 12.5 nM) increased pERK levels, whereas protein kinase C (PKC) depletion or inhibition by GF109203X (GF; 0.01-10 microM) suppressed GnRH-activated ERKs.	Tetradecanoylphorbol Acetate	57-60	mitogen-activated protein kinase 1	Homo sapiens	209-213
11895881-0	2002	Adrenalectomy abrogates reduction of 12-O-tetradecanoylphorbol-13-acetate-induced extracellular signal-regulated protein kinase activity in the epidermis of dietary energy-restricted SENCAR mice: implications of glucocorticoid hormone.	Tetradecanoylphorbol Acetate	37-73	mitogen-activated protein kinase 1	Mus musculus	82-127
11857424-5	2002	This cell line, K562/TPA, shows a non-P-glycoprotein-mediated multidrug-resistant phenotype.	Tetradecanoylphorbol Acetate	21-24	ATP binding cassette subfamily B member 1	Homo sapiens	38-52
11777908-1	2002	We previously found that bikunin (bik), a Kunitz-type protease inhibitor, suppresses phorbol ester (PMA)-stimulated expression of urokinase-type plasminogen activator (uPA).	Tetradecanoylphorbol Acetate	100-103	plasminogen activator, urokinase	Homo sapiens	130-166
11777908-1	2002	We previously found that bikunin (bik), a Kunitz-type protease inhibitor, suppresses phorbol ester (PMA)-stimulated expression of urokinase-type plasminogen activator (uPA).	Tetradecanoylphorbol Acetate	100-103	plasminogen activator, urokinase	Homo sapiens	168-171
11864993-7	2002	A mechanism whereby PKC alpha might regulate hypertrophy was suggested by the observations that wild-type PKC alpha induced extracellular signal-regulated kinase1/2 (ERK1/2), that dominant negative PKC alpha inhibited PMA-induced ERK1/2 activation, and that dominant negative MEK1 (up-stream of ERK1/2) inhibited wild-type PKC alpha-induced hypertrophic growth.	Tetradecanoylphorbol Acetate	218-221	protein kinase C alpha	Homo sapiens	20-29
11864993-7	2002	A mechanism whereby PKC alpha might regulate hypertrophy was suggested by the observations that wild-type PKC alpha induced extracellular signal-regulated kinase1/2 (ERK1/2), that dominant negative PKC alpha inhibited PMA-induced ERK1/2 activation, and that dominant negative MEK1 (up-stream of ERK1/2) inhibited wild-type PKC alpha-induced hypertrophic growth.	Tetradecanoylphorbol Acetate	218-221	protein kinase C alpha	Homo sapiens	106-115
11864993-7	2002	A mechanism whereby PKC alpha might regulate hypertrophy was suggested by the observations that wild-type PKC alpha induced extracellular signal-regulated kinase1/2 (ERK1/2), that dominant negative PKC alpha inhibited PMA-induced ERK1/2 activation, and that dominant negative MEK1 (up-stream of ERK1/2) inhibited wild-type PKC alpha-induced hypertrophic growth.	Tetradecanoylphorbol Acetate	218-221	mitogen-activated protein kinase 1	Homo sapiens	124-164
11864993-7	2002	A mechanism whereby PKC alpha might regulate hypertrophy was suggested by the observations that wild-type PKC alpha induced extracellular signal-regulated kinase1/2 (ERK1/2), that dominant negative PKC alpha inhibited PMA-induced ERK1/2 activation, and that dominant negative MEK1 (up-stream of ERK1/2) inhibited wild-type PKC alpha-induced hypertrophic growth.	Tetradecanoylphorbol Acetate	218-221	protein kinase C alpha	Homo sapiens	106-115
11864993-7	2002	A mechanism whereby PKC alpha might regulate hypertrophy was suggested by the observations that wild-type PKC alpha induced extracellular signal-regulated kinase1/2 (ERK1/2), that dominant negative PKC alpha inhibited PMA-induced ERK1/2 activation, and that dominant negative MEK1 (up-stream of ERK1/2) inhibited wild-type PKC alpha-induced hypertrophic growth.	Tetradecanoylphorbol Acetate	218-221	mitogen-activated protein kinase 3	Homo sapiens	230-236
11864993-7	2002	A mechanism whereby PKC alpha might regulate hypertrophy was suggested by the observations that wild-type PKC alpha induced extracellular signal-regulated kinase1/2 (ERK1/2), that dominant negative PKC alpha inhibited PMA-induced ERK1/2 activation, and that dominant negative MEK1 (up-stream of ERK1/2) inhibited wild-type PKC alpha-induced hypertrophic growth.	Tetradecanoylphorbol Acetate	218-221	mitogen-activated protein kinase 3	Homo sapiens	230-236
11864993-7	2002	A mechanism whereby PKC alpha might regulate hypertrophy was suggested by the observations that wild-type PKC alpha induced extracellular signal-regulated kinase1/2 (ERK1/2), that dominant negative PKC alpha inhibited PMA-induced ERK1/2 activation, and that dominant negative MEK1 (up-stream of ERK1/2) inhibited wild-type PKC alpha-induced hypertrophic growth.	Tetradecanoylphorbol Acetate	218-221	protein kinase C alpha	Homo sapiens	106-115
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	33-36	parathyroid hormone	Rattus norvegicus	145-148
11867340-3	2002	Activation of HAM with LPS and PMA increases the respiratory burst and TNF-alpha release through activation of the extracellular signal-related protein kinases 1 and 2 (ERK1/2) pathway, because these effects are inhibited by treatment of HAM with PD98059, a selective inhibitor of mitogen-activated protein (MAP)/ERK kinases (MEK) pathway.	Tetradecanoylphorbol Acetate	31-34	tumor necrosis factor	Homo sapiens	71-80
11867340-3	2002	Activation of HAM with LPS and PMA increases the respiratory burst and TNF-alpha release through activation of the extracellular signal-related protein kinases 1 and 2 (ERK1/2) pathway, because these effects are inhibited by treatment of HAM with PD98059, a selective inhibitor of mitogen-activated protein (MAP)/ERK kinases (MEK) pathway.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 3	Homo sapiens	169-175
12014641-1	2002	In a previous study, we found that TPA-mediated up-regulation of p21(WAF1/CIP1) induces growth arrest and differentiation of the human prostate cancer cell line TSU-Pr1.	Tetradecanoylphorbol Acetate	35-38	cyclin dependent kinase inhibitor 1A	Homo sapiens	65-68
12014641-1	2002	In a previous study, we found that TPA-mediated up-regulation of p21(WAF1/CIP1) induces growth arrest and differentiation of the human prostate cancer cell line TSU-Pr1.	Tetradecanoylphorbol Acetate	35-38	cyclin dependent kinase inhibitor 1A	Homo sapiens	69-73
12014641-1	2002	In a previous study, we found that TPA-mediated up-regulation of p21(WAF1/CIP1) induces growth arrest and differentiation of the human prostate cancer cell line TSU-Pr1.	Tetradecanoylphorbol Acetate	35-38	cyclin dependent kinase inhibitor 1A	Homo sapiens	74-78
12014641-6	2002	TPA induced up-regulation of p21(WAF1/CIP1) protein levels in all four cancer cell lines and this up-regulation was regulated by PKC in all four, but MAP kinase was associated with regulation only in TSU-Pr1 cells.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	29-32
12014641-6	2002	TPA induced up-regulation of p21(WAF1/CIP1) protein levels in all four cancer cell lines and this up-regulation was regulated by PKC in all four, but MAP kinase was associated with regulation only in TSU-Pr1 cells.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	33-42
12014641-9	2002	The pathway of TPA-induced increases in p21(WAF1/CIP1) levels was regulated by PKC.	Tetradecanoylphorbol Acetate	15-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	40-43
12014641-9	2002	The pathway of TPA-induced increases in p21(WAF1/CIP1) levels was regulated by PKC.	Tetradecanoylphorbol Acetate	15-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	44-48
12014641-9	2002	The pathway of TPA-induced increases in p21(WAF1/CIP1) levels was regulated by PKC.	Tetradecanoylphorbol Acetate	15-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	49-53
11888895-2	2002	However, our recent reports indicated that 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced tumor development is suppressed in Jnk2 knockout mice but enhanced in Jnk1 knockout mice.	Tetradecanoylphorbol Acetate	74-110	mitogen-activated protein kinase 9	Mus musculus	154-158
11888903-3	2002	We have found previously that skin tumor formation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), is suppressed in JNK2-deficient (Jnk2(-/-)) mice.	Tetradecanoylphorbol Acetate	82-118	mitogen-activated protein kinase 9	Mus musculus	159-163
11888903-3	2002	We have found previously that skin tumor formation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), is suppressed in JNK2-deficient (Jnk2(-/-)) mice.	Tetradecanoylphorbol Acetate	120-123	mitogen-activated protein kinase 9	Mus musculus	159-163
11857424-7	2002	The expression of EGFR and EGFR mRNA was clearly present in K562/TPA but not in parental K562 cells as determined by Western blotting and RT-PCR.	Tetradecanoylphorbol Acetate	65-68	epidermal growth factor receptor	Homo sapiens	18-22
11857424-7	2002	The expression of EGFR and EGFR mRNA was clearly present in K562/TPA but not in parental K562 cells as determined by Western blotting and RT-PCR.	Tetradecanoylphorbol Acetate	65-68	epidermal growth factor receptor	Homo sapiens	27-31
11857424-8	2002	EGFR was autophosphorylated in K562/TPA detected by the antiphosphotyrosine antibody.	Tetradecanoylphorbol Acetate	36-39	epidermal growth factor receptor	Homo sapiens	0-4
11877485-5	2002	In contrast, CD4(+) CD1d-restricted NKT cells potently produced both Th1 and Th2 cytokines, up-regulated perforin in response to stimulation by phorbol myristate acetate and ionomycin but not IL-2 or IL-12, and could be induced to express CD95L.	Tetradecanoylphorbol Acetate	144-169	CD4 molecule	Homo sapiens	13-16
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	0-31	parathyroid hormone	Rattus norvegicus	145-148
11957366-7	2002	When all the conditions were compared, the PMA effect was significantly higher than those observed with other stimuli; furthermore, the expression upon incubation with fMLP and LTB4 was statistically significant.	Tetradecanoylphorbol Acetate	43-46	formyl peptide receptor 1	Homo sapiens	168-172
11895881-1	2002	Previous studies in this laboratory demonstrated that dietary energy restriction (DER), a potent inhibitor of skin carcinogenesis, markedly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced extracellular signal-regulated protein kinase (ERK) activity in mouse epidermis.	Tetradecanoylphorbol Acetate	151-187	mitogen-activated protein kinase 1	Mus musculus	202-247
11895881-1	2002	Previous studies in this laboratory demonstrated that dietary energy restriction (DER), a potent inhibitor of skin carcinogenesis, markedly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced extracellular signal-regulated protein kinase (ERK) activity in mouse epidermis.	Tetradecanoylphorbol Acetate	151-187	mitogen-activated protein kinase 1	Mus musculus	249-252
11895881-1	2002	Previous studies in this laboratory demonstrated that dietary energy restriction (DER), a potent inhibitor of skin carcinogenesis, markedly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced extracellular signal-regulated protein kinase (ERK) activity in mouse epidermis.	Tetradecanoylphorbol Acetate	189-192	mitogen-activated protein kinase 1	Mus musculus	202-247
11895881-1	2002	Previous studies in this laboratory demonstrated that dietary energy restriction (DER), a potent inhibitor of skin carcinogenesis, markedly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced extracellular signal-regulated protein kinase (ERK) activity in mouse epidermis.	Tetradecanoylphorbol Acetate	189-192	mitogen-activated protein kinase 1	Mus musculus	249-252
11895881-5	2002	ERK activity measured 1 h after the last TPA treatment was significantly inhibited by DER in sham-operated mice, whereas the ERK inhibitory effect of DER was completely abolished in Adx mice.	Tetradecanoylphorbol Acetate	41-44	mitogen-activated protein kinase 1	Mus musculus	0-3
11895881-9	2002	Addition of corticosterone in the drinking water restored plasma hormone level and markedly decreased TPA-induced ERK activity in Adx mice (P &lt; 0.05).	Tetradecanoylphorbol Acetate	102-105	mitogen-activated protein kinase 1	Mus musculus	114-117
11895881-10	2002	These results provide strong evidence that intact adrenal glands are essential for the DER inhibition of ERK induction by TPA and that corticosterone plays a critical role in the DER blockage of ERK induction.	Tetradecanoylphorbol Acetate	122-125	mitogen-activated protein kinase 1	Mus musculus	105-108
11861527-5	2002	The PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA), but not the Ca(2+) ionophore ionomycin, stimulated LHbeta-CAT activity.	Tetradecanoylphorbol Acetate	18-54	luteinizing hormone subunit beta	Rattus norvegicus	113-119
11861527-5	2002	The PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA), but not the Ca(2+) ionophore ionomycin, stimulated LHbeta-CAT activity.	Tetradecanoylphorbol Acetate	56-59	luteinizing hormone subunit beta	Rattus norvegicus	113-119
11739373-3	2002	Immunoprecipitation/Western blot studies revealed a robust increase in tyrosine phosphorylation of the non-receptor tyrosine kinase, PYK2, in A7r5 cells treated with 4beta-phorbol 12-myristate 13-acetate or ionomycin.	Tetradecanoylphorbol Acetate	166-203	protein tyrosine kinase 2 beta	Rattus norvegicus	133-137
11944969-8	2002	In this case, the Ca(2+) ionophore A23187 and protein kinase C activator TPA were effective in elevating basal levels of prolactin secretion in perifused goldfish pituitary cells.	Tetradecanoylphorbol Acetate	73-76	prolactin	Homo sapiens	121-130
11836568-8	2002	At 40 microM, p-XSC suppressed phorbol myristate acetate (PMA)-induced COX-2 expression in NCI-H460 cells by more than 66%.	Tetradecanoylphorbol Acetate	31-56	prostaglandin-endoperoxide synthase 2	Homo sapiens	71-76
11836568-8	2002	At 40 microM, p-XSC suppressed phorbol myristate acetate (PMA)-induced COX-2 expression in NCI-H460 cells by more than 66%.	Tetradecanoylphorbol Acetate	58-61	prostaglandin-endoperoxide synthase 2	Homo sapiens	71-76
11751911-6	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC activator, stimulated ICAM-1 expression; this effect was inhibited by tyrosine kinase or Src inhibitor.	Tetradecanoylphorbol Acetate	0-36	protein kinase C alpha	Homo sapiens	46-49
11751911-6	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC activator, stimulated ICAM-1 expression; this effect was inhibited by tyrosine kinase or Src inhibitor.	Tetradecanoylphorbol Acetate	0-36	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	139-142
11751911-6	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC activator, stimulated ICAM-1 expression; this effect was inhibited by tyrosine kinase or Src inhibitor.	Tetradecanoylphorbol Acetate	38-41	protein kinase C alpha	Homo sapiens	46-49
11751911-6	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC activator, stimulated ICAM-1 expression; this effect was inhibited by tyrosine kinase or Src inhibitor.	Tetradecanoylphorbol Acetate	38-41	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	139-142
11751911-9	2002	The IFN-gamma-induced ICAM-1 promoter activity was inhibited by tyrosine kinase inhibitors, a phosphatidylinositol-phospholipase C inhibitor, or PKC inhibitors, and the TPA-induced ICAM-1 promoter activity was also inhibited by tyrosine kinase inhibitors.	Tetradecanoylphorbol Acetate	169-172	interferon gamma	Homo sapiens	4-13
11751911-11	2002	However, cotransfection with dominant negative mutants of PKCalpha or c-Src inhibited both IFN-gamma- and TPA-induced ICAM-1 promoter activity.	Tetradecanoylphorbol Acetate	106-109	protein kinase C alpha	Homo sapiens	58-66
11751911-11	2002	However, cotransfection with dominant negative mutants of PKCalpha or c-Src inhibited both IFN-gamma- and TPA-induced ICAM-1 promoter activity.	Tetradecanoylphorbol Acetate	106-109	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	70-75
11751911-13	2002	An immunocomplex kinase assay showed that both IFN-gamma and TPA activated c-Src and Lyn activities and that these effects were inhibited by staurosporine and herbimycin.	Tetradecanoylphorbol Acetate	61-64	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	75-80
11751911-13	2002	An immunocomplex kinase assay showed that both IFN-gamma and TPA activated c-Src and Lyn activities and that these effects were inhibited by staurosporine and herbimycin.	Tetradecanoylphorbol Acetate	61-64	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	85-88
11874241-7	2002	TGF-beta increased FGF-2 mRNA expression within 2 h and this was sustained for 24 h. Phorbal myristate acetate (PMA; 1 microM) also increased FGF-2 mRNA at 6 h. Time course studies showed that TGF-beta did not significantly alter FGFR1 or FGFR2 mRNA expression in MG-63 cells.	Tetradecanoylphorbol Acetate	112-115	fibroblast growth factor 2	Homo sapiens	142-147
11874241-7	2002	TGF-beta increased FGF-2 mRNA expression within 2 h and this was sustained for 24 h. Phorbal myristate acetate (PMA; 1 microM) also increased FGF-2 mRNA at 6 h. Time course studies showed that TGF-beta did not significantly alter FGFR1 or FGFR2 mRNA expression in MG-63 cells.	Tetradecanoylphorbol Acetate	112-115	transforming growth factor beta 1	Homo sapiens	193-201
11914583-2	2002	Among the family of MAPK, PMA only increased the activity of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	26-29	mitogen-activated protein kinase 1	Homo sapiens	20-24
11874241-7	2002	TGF-beta increased FGF-2 mRNA expression within 2 h and this was sustained for 24 h. Phorbal myristate acetate (PMA; 1 microM) also increased FGF-2 mRNA at 6 h. Time course studies showed that TGF-beta did not significantly alter FGFR1 or FGFR2 mRNA expression in MG-63 cells.	Tetradecanoylphorbol Acetate	112-115	fibroblast growth factor receptor 1	Homo sapiens	230-235
11914583-2	2002	Among the family of MAPK, PMA only increased the activity of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	26-29	mitogen-activated protein kinase 1	Homo sapiens	61-98
11914583-2	2002	Among the family of MAPK, PMA only increased the activity of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	26-29	mitogen-activated protein kinase 1	Homo sapiens	100-103
12030372-5	2002	Further EPA and DHA diminished both the PMA- and antiCD3 antibodies-induced enzyme activity of ERK1/ERK2 in Jurkat T-cells.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 3	Homo sapiens	95-99
11914583-3	2002	Treatment of cells with PD98059, which is an inhibitor of mitogen-activated protein kinase kinase (MEK), decreased the PMA-induced expression of 12(S)-lipoxygenase.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase kinase 7	Homo sapiens	58-97
11914583-3	2002	Treatment of cells with PD98059, which is an inhibitor of mitogen-activated protein kinase kinase (MEK), decreased the PMA-induced expression of 12(S)-lipoxygenase.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase kinase 7	Homo sapiens	99-102
11874475-5	2002	At protein level, spontaneous fibroblast growth factor 2 secretion was noted that was markedly enhanced by phorbol myristate acetate, whereas no fibroblast growth factor 7 protein was detected under these conditions.	Tetradecanoylphorbol Acetate	107-132	fibroblast growth factor 2	Homo sapiens	30-56
11874493-2	2002	Phorbol-12-myristate-13-acetate differentiated THP-1 into macrophage-like cells.	Tetradecanoylphorbol Acetate	0-31	GLI family zinc finger 2	Homo sapiens	47-52
11861786-4	2002	This effect was significantly reduced by the PKC-specific inhibitor bisindolylmaleimide (GF109203X), by down-regulation of PKC with 12-O-tetradecanoyl-phorbol 13-acetate, by a pseudosubstrate to PKCalpha, and by selective down-regulation of PKCalpha by prior lead exposure.	Tetradecanoylphorbol Acetate	132-169	protein kinase C alpha	Homo sapiens	45-48
11861786-4	2002	This effect was significantly reduced by the PKC-specific inhibitor bisindolylmaleimide (GF109203X), by down-regulation of PKC with 12-O-tetradecanoyl-phorbol 13-acetate, by a pseudosubstrate to PKCalpha, and by selective down-regulation of PKCalpha by prior lead exposure.	Tetradecanoylphorbol Acetate	132-169	protein kinase C alpha	Homo sapiens	123-126
11861786-4	2002	This effect was significantly reduced by the PKC-specific inhibitor bisindolylmaleimide (GF109203X), by down-regulation of PKC with 12-O-tetradecanoyl-phorbol 13-acetate, by a pseudosubstrate to PKCalpha, and by selective down-regulation of PKCalpha by prior lead exposure.	Tetradecanoylphorbol Acetate	132-169	protein kinase C alpha	Homo sapiens	241-249
11875115-6	2002	Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3.	Tetradecanoylphorbol Acetate	31-67	isoleucyl-tRNA synthetase 1	Homo sapiens	147-150
12030372-5	2002	Further EPA and DHA diminished both the PMA- and antiCD3 antibodies-induced enzyme activity of ERK1/ERK2 in Jurkat T-cells.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 1	Homo sapiens	100-104
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Mus musculus	32-35
11744714-8	2002	12-O-Tetradecanoyl phorbol 13-acetate (16 nm), a PKC activator, reproduced the effects of gp160 in untreated cells.	Tetradecanoylphorbol Acetate	0-37	protein kinase C alpha	Homo sapiens	49-52
11841924-8	2002	In contrast, alpha-tocopherol potently inhibited the PMA-induced ERK activation in smooth muscle cells.	Tetradecanoylphorbol Acetate	53-56	mitogen-activated protein kinase 1	Mus musculus	65-68
11751871-3	2002	Further analysis demonstrated that serum or 12-O-tetradecanoylphorbol-13-acetate activation of several immediate early genes including fos, fosB, junB, and egr1 was inhibited by Wnt signaling.	Tetradecanoylphorbol Acetate	44-80	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	146-150
11751871-3	2002	Further analysis demonstrated that serum or 12-O-tetradecanoylphorbol-13-acetate activation of several immediate early genes including fos, fosB, junB, and egr1 was inhibited by Wnt signaling.	Tetradecanoylphorbol Acetate	44-80	Wnt family member 1	Homo sapiens	178-181
11861377-6	2002	We also demonstrated that nobiletin suppressed the 12-O-tetradecanoylphorbol 13-acetate-induced binding activity of activator protein-1.	Tetradecanoylphorbol Acetate	51-87	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-135
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	0-3	GATA binding protein 4	Mus musculus	153-159
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Mus musculus	172-175
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	41-44	GATA binding protein 4	Mus musculus	53-59
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	41-44	GATA binding protein 4	Mus musculus	153-159
11842109-5	2002	Transactivation by c-Maf was inhibited by activation of protein kinase A (PKA) (by signal transduction agonist forskolin) or of protein kinase C (PKC) (by signal transduction agonist tetradecanoyl phorbol acetate).	Tetradecanoylphorbol Acetate	183-212	MAF bZIP transcription factor	Rattus norvegicus	19-24
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	41-44	mitogen-activated protein kinase 1	Mus musculus	172-175
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	41-44	GATA binding protein 4	Mus musculus	53-59
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	41-44	GATA binding protein 4	Mus musculus	153-159
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	41-44	mitogen-activated protein kinase 1	Mus musculus	172-175
11729181-3	2002	In this study, we demonstrated that PMA also protects Jurkat cells from apoptosis induced by tumor necrosis factor-alpha and the tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL).	Tetradecanoylphorbol Acetate	36-39	tumor necrosis factor	Homo sapiens	93-120
11820799-2	2002	Immobilized TSP-1 enhanced IL-6 release from the human monocytic U937 cells stimulated with phorbol myristate acetate and LPS, whereas it inhibited IL-10 release.	Tetradecanoylphorbol Acetate	92-117	thrombospondin 1	Homo sapiens	12-17
11850819-4	2002	Here we show that c-Jun N-terminal Kinase (JNK) is activated strongly and in a sustained fashion by 12-O-tetradecanoylphorbol 13-acetate (TPA) and thapsigargin (TG), two agents which were previously shown to lead to apoptosis in the androgen responsive prostate cancer cell line LNCaP.	Tetradecanoylphorbol Acetate	100-136	mitogen-activated protein kinase 8	Homo sapiens	18-41
11850819-4	2002	Here we show that c-Jun N-terminal Kinase (JNK) is activated strongly and in a sustained fashion by 12-O-tetradecanoylphorbol 13-acetate (TPA) and thapsigargin (TG), two agents which were previously shown to lead to apoptosis in the androgen responsive prostate cancer cell line LNCaP.	Tetradecanoylphorbol Acetate	100-136	mitogen-activated protein kinase 8	Homo sapiens	43-46
11850819-4	2002	Here we show that c-Jun N-terminal Kinase (JNK) is activated strongly and in a sustained fashion by 12-O-tetradecanoylphorbol 13-acetate (TPA) and thapsigargin (TG), two agents which were previously shown to lead to apoptosis in the androgen responsive prostate cancer cell line LNCaP.	Tetradecanoylphorbol Acetate	138-141	mitogen-activated protein kinase 8	Homo sapiens	18-41
11850819-4	2002	Here we show that c-Jun N-terminal Kinase (JNK) is activated strongly and in a sustained fashion by 12-O-tetradecanoylphorbol 13-acetate (TPA) and thapsigargin (TG), two agents which were previously shown to lead to apoptosis in the androgen responsive prostate cancer cell line LNCaP.	Tetradecanoylphorbol Acetate	138-141	mitogen-activated protein kinase 8	Homo sapiens	43-46
11850819-9	2002	Specific inhibition of JNK by expression of the JNK Inhibitory Protein (JIP) dramatically inhibited both TPA- and TG-induced apoptosis.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase 8	Homo sapiens	23-26
11886844-3	2002	We demonstrated that medium and long-sized galectin-9 isoforms were constitutively expressed, and phorbol 12-myriastate 13-acetate (PMA) upregulated the level of galectin-9 mRNA in Jurkat cells.	Tetradecanoylphorbol Acetate	132-135	galectin 9	Homo sapiens	162-172
11886844-7	2002	When Jurkat cells were stimulated with PMA in the presence of a BB94, a matrix metalloproteinase (MMP) inhibitor, but not tissue inhibitor of metalloproteinase-1 (TIMP-1), the release of galectin-9 was suppressed in a dose-dependent manner.	Tetradecanoylphorbol Acetate	39-42	galectin 9	Homo sapiens	187-197
11724792-4	2002	Phorbol 12-myristate 13-acetate activation of neutrophils resulted in the production of both 2-chlorohexadecanal and 2- chlorooctadecanal through a myeloperoxidase-dependent mechanism that likely involved the targeting of both 16 and 18 carbon vinyl ether-linked aliphatic groups present in the sn-1 position of neutrophil plasmalogens.	Tetradecanoylphorbol Acetate	0-31	myeloperoxidase	Homo sapiens	148-163
11726648-6	2002	Using human monocytes and T lymphocytes from same donors, we have found that monocyte 12/15-LO products mediate the indirect inhibitory effect of IL-4 on anti-CD3- or phytohemagglutinin/phorbol 12-myristate 13-acetate-stimulated IL-2 production by T lymphocytes.	Tetradecanoylphorbol Acetate	186-217	interleukin 4	Homo sapiens	146-150
11792626-9	2002	Interestingly, unlike in S6 cells, a catalytically inactive c-Jun NH(2)-terminal kinase (JNK) 1 mutant significantly reduced the PMA-inducible SPRR1B promoter activity in H441 cells.	Tetradecanoylphorbol Acetate	129-132	mitogen-activated protein kinase 8	Homo sapiens	60-95
11952825-3	2002	An overnight treatment of isolated HaCaT keratinocytes with phorbol 12-myristate 13-acetate (PMA) selectively downregulated the classical, calcium-dependent protein kinase C (PKC) isoenzyme PKC alpha in preconfluent cells.	Tetradecanoylphorbol Acetate	60-91	protein kinase C alpha	Homo sapiens	175-178
11952825-3	2002	An overnight treatment of isolated HaCaT keratinocytes with phorbol 12-myristate 13-acetate (PMA) selectively downregulated the classical, calcium-dependent protein kinase C (PKC) isoenzyme PKC alpha in preconfluent cells.	Tetradecanoylphorbol Acetate	60-91	protein kinase C alpha	Homo sapiens	190-199
11952825-3	2002	An overnight treatment of isolated HaCaT keratinocytes with phorbol 12-myristate 13-acetate (PMA) selectively downregulated the classical, calcium-dependent protein kinase C (PKC) isoenzyme PKC alpha in preconfluent cells.	Tetradecanoylphorbol Acetate	93-96	protein kinase C alpha	Homo sapiens	175-178
11952825-3	2002	An overnight treatment of isolated HaCaT keratinocytes with phorbol 12-myristate 13-acetate (PMA) selectively downregulated the classical, calcium-dependent protein kinase C (PKC) isoenzyme PKC alpha in preconfluent cells.	Tetradecanoylphorbol Acetate	93-96	protein kinase C alpha	Homo sapiens	190-199
11882599-3	2002	Phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, inhibited the insulin-induced phosphorylation of Akt.	Tetradecanoylphorbol Acetate	0-31	AKT serine/threonine kinase 1	Rattus norvegicus	124-127
11882599-3	2002	Phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, inhibited the insulin-induced phosphorylation of Akt.	Tetradecanoylphorbol Acetate	33-36	AKT serine/threonine kinase 1	Rattus norvegicus	124-127
11729181-3	2002	In this study, we demonstrated that PMA also protects Jurkat cells from apoptosis induced by tumor necrosis factor-alpha and the tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL).	Tetradecanoylphorbol Acetate	36-39	TNF superfamily member 10	Homo sapiens	129-190
11729181-3	2002	In this study, we demonstrated that PMA also protects Jurkat cells from apoptosis induced by tumor necrosis factor-alpha and the tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL).	Tetradecanoylphorbol Acetate	36-39	TNF superfamily member 10	Homo sapiens	192-197
11927127-7	2002	In contrast, JEG-3 and, to a lesser extent, BeWo produced significant amounts of TFPI-2 mRNA, which were significantly increased after stimulation with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	152-183	tissue factor pathway inhibitor 2	Homo sapiens	81-87
11897504-8	2002	In breast adenocarcinoma cells, EGF and TGFbeta did not alter COX-2 levels at 24h, while TPA induced COX-2 levels by 75% in MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	89-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	101-106
11897504-12	2002	A dramatic induction of COX-2 was observed in the adipose stromal cells by EGF, TGFbeta, and TPA.	Tetradecanoylphorbol Acetate	93-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29
11809859-4	2002	In C9 cells, phorbol-12-myristate-13-acetate (PMA) caused much greater phosphorylation of Pyk2 and ERK than the Ca(2+) ionophore ionomycin, and the effects of PMA and Ang II were abolished in PKC-depleted cells.	Tetradecanoylphorbol Acetate	13-44	angiotensinogen	Homo sapiens	167-173
11809859-4	2002	In C9 cells, phorbol-12-myristate-13-acetate (PMA) caused much greater phosphorylation of Pyk2 and ERK than the Ca(2+) ionophore ionomycin, and the effects of PMA and Ang II were abolished in PKC-depleted cells.	Tetradecanoylphorbol Acetate	46-49	angiotensinogen	Homo sapiens	167-173
11896934-1	2002	The aim of this study was to investigate whether neutrophil adhesion to extracellular matrix proteins like fibronectin, fibrinogen, and albumin influence the release proteins from primary and secondary granules of neutrophils stimulated by phorbol-myristate-acetate (PMA) and formyl-methionyl-leucyl-phenylalanine (f-MLP).	Tetradecanoylphorbol Acetate	240-265	fibronectin 1	Homo sapiens	107-118
11896934-1	2002	The aim of this study was to investigate whether neutrophil adhesion to extracellular matrix proteins like fibronectin, fibrinogen, and albumin influence the release proteins from primary and secondary granules of neutrophils stimulated by phorbol-myristate-acetate (PMA) and formyl-methionyl-leucyl-phenylalanine (f-MLP).	Tetradecanoylphorbol Acetate	240-265	fibrinogen beta chain	Homo sapiens	120-130
11896934-1	2002	The aim of this study was to investigate whether neutrophil adhesion to extracellular matrix proteins like fibronectin, fibrinogen, and albumin influence the release proteins from primary and secondary granules of neutrophils stimulated by phorbol-myristate-acetate (PMA) and formyl-methionyl-leucyl-phenylalanine (f-MLP).	Tetradecanoylphorbol Acetate	267-270	fibronectin 1	Homo sapiens	107-118
11809863-9	2002	The induction of Egr-1 in rat neonatal ventricular myocytes with phorbol-12-myristate-13-acetate or in HeLa S3 cells by regulated expression of Egr-1 in a tetracycline-responsive promoter, suppressed expression from the beta(1)-AR promoter.	Tetradecanoylphorbol Acetate	65-96	early growth response 1	Rattus norvegicus	17-22
11952172-7	2002	In our experimental conditions phorbol myristate acetate (PMA) induced a rapid depletion of PKCalpha in the cytosolic fraction and its translocation toward the particulate fraction.	Tetradecanoylphorbol Acetate	31-56	protein kinase C alpha	Homo sapiens	92-100
11952172-7	2002	In our experimental conditions phorbol myristate acetate (PMA) induced a rapid depletion of PKCalpha in the cytosolic fraction and its translocation toward the particulate fraction.	Tetradecanoylphorbol Acetate	58-61	protein kinase C alpha	Homo sapiens	92-100
11952172-8	2002	Long term exposure of myotubes in the presence of PMA induced down-regulation of PKCalpha, this process being partially blocked by calpain inhibitors (CS peptide and inhibitor II) and antisense oligonucleotides for the two major ubiquitous calpain isoforms (m- and micro-calpains).	Tetradecanoylphorbol Acetate	50-53	protein kinase C alpha	Homo sapiens	81-89
11927127-7	2002	In contrast, JEG-3 and, to a lesser extent, BeWo produced significant amounts of TFPI-2 mRNA, which were significantly increased after stimulation with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	185-188	tissue factor pathway inhibitor 2	Homo sapiens	81-87
11777342-0	2002	1alpha,25-dihydroxyvitamin D3 stimulates phosphorylation of IkappaBalpha and synergizes with TPA to induce nuclear translocation of NFkappaB during monocytic differentiation of NB4 leukemia cells.	Tetradecanoylphorbol Acetate	93-96	nuclear factor kappa B subunit 1	Homo sapiens	132-140
11840337-11	2002	Finally TFPI-2 was induced in Hs683 cells transfected with the pTF6 construct (-312 to +1) and stimulated with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	111-142	tissue factor pathway inhibitor 2	Homo sapiens	8-14
11840337-11	2002	Finally TFPI-2 was induced in Hs683 cells transfected with the pTF6 construct (-312 to +1) and stimulated with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	144-147	tissue factor pathway inhibitor 2	Homo sapiens	8-14
11840342-8	2002	TPA causes positive regulation of Cyr61 expression in ER-positive MCF-7 cells.	Tetradecanoylphorbol Acetate	0-3	estrogen receptor 1	Homo sapiens	54-56
11777342-4	2002	In this study we identify the NFkappaB/IkappaB signaling pathway as a target of 1,25D3 and TPA action.	Tetradecanoylphorbol Acetate	91-94	nuclear factor kappa B subunit 1	Homo sapiens	30-38
11777342-6	2002	On their own, 1,25D3, its analogs, and TPA do not alter IkappaBalpha expression; however, combinations of analogs with TPA result in a synergistic decrease in IkappaBalpha expression.	Tetradecanoylphorbol Acetate	119-122	NFKB inhibitor alpha	Homo sapiens	159-171
11719086-5	2002	In the hyperlipidemic patients, a positive correlation was found between the degree of DNA damage and the basic oxidation of PMNLs (r=0.517), and the superoxide anion production of the cells stimulated with phorbolmiristate acetate (PMA) (r=0.326) and formyl-Met-Leu-Phe (FMLP) (r=0.525) as well.	Tetradecanoylphorbol Acetate	233-236	formyl peptide receptor 1	Homo sapiens	252-270
11719086-5	2002	In the hyperlipidemic patients, a positive correlation was found between the degree of DNA damage and the basic oxidation of PMNLs (r=0.517), and the superoxide anion production of the cells stimulated with phorbolmiristate acetate (PMA) (r=0.326) and formyl-Met-Leu-Phe (FMLP) (r=0.525) as well.	Tetradecanoylphorbol Acetate	233-236	formyl peptide receptor 1	Homo sapiens	272-276
11779159-4	2002	K562 cells treated with a combination of Lf and PMA showed a synergistic induction in the level of IL-1beta mRNA over treatment with PMA alone.	Tetradecanoylphorbol Acetate	48-51	interleukin 1 beta	Homo sapiens	99-107
11886168-2	2002	In this study, IL-4 did not induce virus production, but inhibited phorbol esters (PMA)-stimulated HIV expression in chronically infected promonocytic U1 cells.	Tetradecanoylphorbol Acetate	83-86	interleukin 4	Homo sapiens	15-19
11584014-5	2002	Moreover, different PKC isozymes were found to mediate the apoptotic effect of phorbol 12-myristate 13-acetate (PMA) and HK654 in LNCaP cells.	Tetradecanoylphorbol Acetate	79-110	protein kinase C alpha	Homo sapiens	20-23
11584014-5	2002	Moreover, different PKC isozymes were found to mediate the apoptotic effect of phorbol 12-myristate 13-acetate (PMA) and HK654 in LNCaP cells.	Tetradecanoylphorbol Acetate	112-115	protein kinase C alpha	Homo sapiens	20-23
11928815-1	2002	The serine proteinase inhibitor plasminogen activator inhibitor type-1 (PAI-1) is the primary physiological inhibitor of the tissue-type and the urokinase-type plasminogen activator (tPA and uPA, respectively) and as such an important regulator of proteolytic events taking place in the circulation and in the extracellular matrix.	Tetradecanoylphorbol Acetate	183-186	plasminogen activator, urokinase	Homo sapiens	145-181
11584014-6	2002	Using PKC inhibitors and dominant negative PKC isoforms, we found that both PKCalpha and PKCdelta mediated the apoptotic effect of PMA, whereas only PKCalpha was involved in the effect of the DAG-lactone.	Tetradecanoylphorbol Acetate	131-134	protein kinase C alpha	Homo sapiens	6-9
11584014-6	2002	Using PKC inhibitors and dominant negative PKC isoforms, we found that both PKCalpha and PKCdelta mediated the apoptotic effect of PMA, whereas only PKCalpha was involved in the effect of the DAG-lactone.	Tetradecanoylphorbol Acetate	131-134	protein kinase C alpha	Homo sapiens	43-46
11584014-6	2002	Using PKC inhibitors and dominant negative PKC isoforms, we found that both PKCalpha and PKCdelta mediated the apoptotic effect of PMA, whereas only PKCalpha was involved in the effect of the DAG-lactone.	Tetradecanoylphorbol Acetate	131-134	protein kinase C alpha	Homo sapiens	76-84
12402613-14	2002	When cells were stimulated by ionomicin and phorbol 12-myristate 13-acetate (PMA), more IFN-gamma appeared and high levels of IL-4 persisted in 75% of the samples, which looked like intent to correct the TH2 immunodeviation toward TH0.	Tetradecanoylphorbol Acetate	44-75	interferon gamma	Homo sapiens	88-97
12402613-14	2002	When cells were stimulated by ionomicin and phorbol 12-myristate 13-acetate (PMA), more IFN-gamma appeared and high levels of IL-4 persisted in 75% of the samples, which looked like intent to correct the TH2 immunodeviation toward TH0.	Tetradecanoylphorbol Acetate	44-75	interleukin 4	Homo sapiens	126-130
12402613-14	2002	When cells were stimulated by ionomicin and phorbol 12-myristate 13-acetate (PMA), more IFN-gamma appeared and high levels of IL-4 persisted in 75% of the samples, which looked like intent to correct the TH2 immunodeviation toward TH0.	Tetradecanoylphorbol Acetate	77-80	interferon gamma	Homo sapiens	88-97
12402613-14	2002	When cells were stimulated by ionomicin and phorbol 12-myristate 13-acetate (PMA), more IFN-gamma appeared and high levels of IL-4 persisted in 75% of the samples, which looked like intent to correct the TH2 immunodeviation toward TH0.	Tetradecanoylphorbol Acetate	77-80	interleukin 4	Homo sapiens	126-130
12136940-4	2002	In this report we provide evidence that the GATA-1 factor regulates alphaV expression during differentiation of pluripotent K562 cells induced either by phorbol 12-myristate 13-acetate (PMA) or butyric acid (BA) through interaction with the GATA element in the alphaV gene promoter.	Tetradecanoylphorbol Acetate	153-184	GATA binding protein 1	Homo sapiens	44-50
12136940-4	2002	In this report we provide evidence that the GATA-1 factor regulates alphaV expression during differentiation of pluripotent K562 cells induced either by phorbol 12-myristate 13-acetate (PMA) or butyric acid (BA) through interaction with the GATA element in the alphaV gene promoter.	Tetradecanoylphorbol Acetate	186-189	GATA binding protein 1	Homo sapiens	44-50
12119537-7	2002	We found that U. urealyticum antigen (&gt;/=4 x 10(7) color-changing units/ml) stimulated human macrophages (phorbol 12-myristate 13-acetate-differentiated THP-1 cell line) to produce VEGF and soluble ICAM-1 in a dose-dependent manner (p &lt; 0.05) measured by ELISA.	Tetradecanoylphorbol Acetate	109-140	vascular endothelial growth factor A	Homo sapiens	184-188
11815375-8	2002	To clarify whether ROS production impeded by ANDRO could be an antagonism of fMLP binding, phorbol-12-myristate-13-acetate (PMA), a direct protein kinase C (PKC) activator, was introduced to activate ROS production.	Tetradecanoylphorbol Acetate	91-122	formyl peptide receptor 1	Homo sapiens	77-81
11801529-0	2002	Expression of toll-like receptors 2 and 4 and CD14 during differentiation of HL-60 cells induced by phorbol 12-myristate 13-acetate and 1 alpha, 25-dihydroxy-vitamin D(3).	Tetradecanoylphorbol Acetate	100-131	toll like receptor 2	Homo sapiens	14-41
11756226-5	2002	The tumor promoters phorbol 12-myristate 13-acetate (PMA) and chenodeoxycholic acid (CD) induced COX-2 protein expression in transformed, but not non-transformed cells.	Tetradecanoylphorbol Acetate	20-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
11756226-5	2002	The tumor promoters phorbol 12-myristate 13-acetate (PMA) and chenodeoxycholic acid (CD) induced COX-2 protein expression in transformed, but not non-transformed cells.	Tetradecanoylphorbol Acetate	53-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
11756226-8	2002	PMA-induced COX-2 expression in both transformed and CYP2E1-expressing cells resulted from an induction in COX-2 mRNA, and was dependent on extracellular signal-regulated kinase, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	12-17
11756226-8	2002	PMA-induced COX-2 expression in both transformed and CYP2E1-expressing cells resulted from an induction in COX-2 mRNA, and was dependent on extracellular signal-regulated kinase, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase.	Tetradecanoylphorbol Acetate	0-3	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	53-59
11756226-8	2002	PMA-induced COX-2 expression in both transformed and CYP2E1-expressing cells resulted from an induction in COX-2 mRNA, and was dependent on extracellular signal-regulated kinase, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
11756226-8	2002	PMA-induced COX-2 expression in both transformed and CYP2E1-expressing cells resulted from an induction in COX-2 mRNA, and was dependent on extracellular signal-regulated kinase, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	179-182
11772508-5	2002	The percentages of CD3+ cells producing TNF-alpha and IFN-gamma were significantly higher in elderly compared to young people (p=0.0049; p=0.0026, respectively) after stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	184-187	tumor necrosis factor	Homo sapiens	40-49
12377207-5	2002	VEGF-induced Akt activation was prevented by down-regulation of PKC induced by prolonged pretreatment with the phorbol ester, PMA.	Tetradecanoylphorbol Acetate	126-129	vascular endothelial growth factor A	Homo sapiens	0-4
12377207-5	2002	VEGF-induced Akt activation was prevented by down-regulation of PKC induced by prolonged pretreatment with the phorbol ester, PMA.	Tetradecanoylphorbol Acetate	126-129	AKT serine/threonine kinase 1	Homo sapiens	13-16
12142035-1	2002	CD4/CD8 lineage commitment of thymocytes is controlled by the T cell receptor-mediated signals and is mimicked in vitro by a long-pulse stimulation of isolated CD4(+)CD8(+) thymocytes with proper combinations of phorbol myristate acetate and the calcium ionophore ionomycin.	Tetradecanoylphorbol Acetate	212-237	CD4 molecule	Homo sapiens	0-3
11882035-3	2002	In order to clarify the relative importance of hsp60 in the inflammatory response in periodontal disease, the stimulatory effect of human and bacterial hsp60 on the production of tumour necrosis factor-alpha (TNF-alpha) was examined in phorbol myristate acetate (PMA)-stimulated THP-1 cells.	Tetradecanoylphorbol Acetate	236-261	tumor necrosis factor	Homo sapiens	209-218
11772508-5	2002	The percentages of CD3+ cells producing TNF-alpha and IFN-gamma were significantly higher in elderly compared to young people (p=0.0049; p=0.0026, respectively) after stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	184-187	interferon gamma	Homo sapiens	54-63
12210750-2	2002	The aim of the present study was to investigate the effect of PKA and PKC activities on the distribution of perilipin and ADRP in primary cultured adrenal cells, and the role of ERK in PMA- and calphostin C-induced steroidogenesis.	Tetradecanoylphorbol Acetate	185-188	Eph receptor B1	Rattus norvegicus	178-181
11849318-4	2002	Chloroquine partially reduced production of soluble p55 and p75 TNF receptors in cells stimulated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	103-134	tumor necrosis factor	Homo sapiens	64-67
11849318-4	2002	Chloroquine partially reduced production of soluble p55 and p75 TNF receptors in cells stimulated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	136-139	tumor necrosis factor	Homo sapiens	64-67
12056641-4	2002	In our study we attempted to investigate the effect of: phorbol ester (PMA)-PKC activator, and bisindolylmaleimide II (GF II), a highly selective PKC inhibitor, on the proliferation as well as induction of apoptosis and necrosis in breast cancer cell line MDA-MB-231.	Tetradecanoylphorbol Acetate	71-74	proline rich transmembrane protein 2	Homo sapiens	76-79
11743653-2	2002	TPA produced tumors in 100% of TNF+/+ and 78% of TNF-/- mice at 20 weeks, and the average number of tumors per mouse was 11.1 in the former group and 2.1 in the latter.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Mus musculus	31-34
11743653-2	2002	TPA produced tumors in 100% of TNF+/+ and 78% of TNF-/- mice at 20 weeks, and the average number of tumors per mouse was 11.1 in the former group and 2.1 in the latter.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Mus musculus	49-52
11743653-3	2002	Judging from the expression of various inflammatory cytokine genes in TNF+/+ and TNF-/- mice, the residual tumor promoting activity of TPA in TNF-/- mice may be dependent on expression of IL-1alpha and IL-1beta genes.	Tetradecanoylphorbol Acetate	135-138	tumor necrosis factor	Mus musculus	70-73
11743653-3	2002	Judging from the expression of various inflammatory cytokine genes in TNF+/+ and TNF-/- mice, the residual tumor promoting activity of TPA in TNF-/- mice may be dependent on expression of IL-1alpha and IL-1beta genes.	Tetradecanoylphorbol Acetate	135-138	tumor necrosis factor	Mus musculus	81-84
11743653-3	2002	Judging from the expression of various inflammatory cytokine genes in TNF+/+ and TNF-/- mice, the residual tumor promoting activity of TPA in TNF-/- mice may be dependent on expression of IL-1alpha and IL-1beta genes.	Tetradecanoylphorbol Acetate	135-138	tumor necrosis factor	Mus musculus	81-84
11743653-3	2002	Judging from the expression of various inflammatory cytokine genes in TNF+/+ and TNF-/- mice, the residual tumor promoting activity of TPA in TNF-/- mice may be dependent on expression of IL-1alpha and IL-1beta genes.	Tetradecanoylphorbol Acetate	135-138	interleukin 1 beta	Mus musculus	202-210
11743653-4	2002	ii) Tumor promotion by TPA and okadaic acid in IL-6+/+ and IL-6-/- C57/BL6 mice was studied, with TPA producing tumors in 57.1% of IL-6+/+ and 40.0% of IL-6-/- mice at 20 weeks, and okadaic acid in 40.0% of IL-6+/+ and 53.3% of IL-6-/- mice.	Tetradecanoylphorbol Acetate	23-26	interleukin 6	Mus musculus	47-51
11781358-5	2002	Whereas a biased Th1 to Th2 cytokine profile has been suggested to underlie the pathogenesis of IMD in both species, we found defective production of IFN-gamma in our patients after in vitro stimulation of their PBMCs by phorbol-myristate acetate and ionomycin and both IFN-gamma and IL-4 deficiencies in V(alpha)24(+) NK T-enriched cells.	Tetradecanoylphorbol Acetate	221-246	interferon gamma	Homo sapiens	150-159
11781358-5	2002	Whereas a biased Th1 to Th2 cytokine profile has been suggested to underlie the pathogenesis of IMD in both species, we found defective production of IFN-gamma in our patients after in vitro stimulation of their PBMCs by phorbol-myristate acetate and ionomycin and both IFN-gamma and IL-4 deficiencies in V(alpha)24(+) NK T-enriched cells.	Tetradecanoylphorbol Acetate	221-246	interferon gamma	Homo sapiens	270-279
11781358-5	2002	Whereas a biased Th1 to Th2 cytokine profile has been suggested to underlie the pathogenesis of IMD in both species, we found defective production of IFN-gamma in our patients after in vitro stimulation of their PBMCs by phorbol-myristate acetate and ionomycin and both IFN-gamma and IL-4 deficiencies in V(alpha)24(+) NK T-enriched cells.	Tetradecanoylphorbol Acetate	221-246	interleukin 4	Homo sapiens	284-288
12086399-6	2002	Topical application on mouse skin of these diarylheptanoids also attenuated the TPA-induced DNA binding activity of the ubiquitous eukaryotic transcription factor NF-kappaB that plays a crucial role in regulating the expression of the aforementioned proinflammatory enzymes and cytokines in response to a wide variety of external stimuli.	Tetradecanoylphorbol Acetate	80-83	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	163-172
12086399-7	2002	These findings suggest that diarylheptanoids contained in Alpinia oxyphylla down-regulate COX-2 and iNOS expression through suppression of NF-kappaB activation in the TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	167-170	nitric oxide synthase 2, inducible	Mus musculus	100-104
12086399-7	2002	These findings suggest that diarylheptanoids contained in Alpinia oxyphylla down-regulate COX-2 and iNOS expression through suppression of NF-kappaB activation in the TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	167-170	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	139-148
11851881-2	2002	Here we determined the anti-inflammatory effects of peroxisome proliferator activated receptor-alpha agonists in models of irritant and allergic contact dermatitis produced in mouse ears by topical treatment with 12-O-tetradecanoylphorbol-13-acetate and oxazalone, respectively.	Tetradecanoylphorbol Acetate	213-249	peroxisome proliferator activated receptor alpha	Mus musculus	52-100
11851881-4	2002	Topical treatment with three different peroxisome proliferator activated receptor-alpha agonists, clofibrate, WY 14643, or linoleic acid, 45 min and 4 h after 12-O-tetradecanoylphorbol-13-acetate application, resulted in a marked decrease in ear thickness and weight and a reduction in the number of inflammatory cells in the dermis.	Tetradecanoylphorbol Acetate	159-195	peroxisome proliferator activated receptor alpha	Mus musculus	39-87
11873244-8	2002	Another agent known for stimulating the protein kinase C pathway, phorbol 12-myristate 13-acetate (10(-8) mol/L), had a similar effect, stimulating chemotaxis to fibronectin (146.2% +/- 8.6%).	Tetradecanoylphorbol Acetate	66-97	fibronectin 1	Homo sapiens	162-173
11734301-3	2002	However, recent reports have clarified that early growth response 1 gene (Egr1) positively regulates MDR1 transcription, while Wilms" tumor suppressor gene (WT1) does negative regulation of MDR1 gene expression in 12-O-tetradecanoylphorbol-13-acetate treated K562 cells.	Tetradecanoylphorbol Acetate	214-250	WT1 transcription factor	Homo sapiens	157-160
11734301-3	2002	However, recent reports have clarified that early growth response 1 gene (Egr1) positively regulates MDR1 transcription, while Wilms" tumor suppressor gene (WT1) does negative regulation of MDR1 gene expression in 12-O-tetradecanoylphorbol-13-acetate treated K562 cells.	Tetradecanoylphorbol Acetate	214-250	ATP binding cassette subfamily B member 1	Homo sapiens	190-194
11851881-8	2002	As tumor necrosis factor-alpha and interleukin-1alpha are major mediators of cutaneous inflammation we next used immunohistochemistry to determine whether the peroxisome proliferator activated receptor-alpha agonists reduce the levels of these cytokines in 12-O-tetradecanoylphorbol-13-acetate-treated skin.	Tetradecanoylphorbol Acetate	257-293	peroxisome proliferator activated receptor alpha	Mus musculus	159-207
11756554-8	2002	Fra-1 was activated by TPA in ERK-sufficient P(+) cells but not in ERK-deficient P(-) cells.	Tetradecanoylphorbol Acetate	23-26	mitogen-activated protein kinase 1	Homo sapiens	30-33
11756559-9	2002	In addition, Cdk4(R24C/R24C) mice showed extraordinary susceptibility to carcinogens and developed papillomas within the first 8 to 10 weeks following cutaneous application of the carcinogens 9,10-di-methyl-1,2-benz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	240-276	cyclin-dependent kinase 4	Mus musculus	13-17
12210750-6	2002	We further demonstrated that ERK pathway was involved in PMA-induced steroidogenesis, since PD98059, specific inhibitor of MEK, blocked the increases in steroidogenesis and phosphorylation of ERK caused by PMA, but not by cAMP-PKA.	Tetradecanoylphorbol Acetate	57-60	Eph receptor B1	Rattus norvegicus	29-32
11756559-9	2002	In addition, Cdk4(R24C/R24C) mice showed extraordinary susceptibility to carcinogens and developed papillomas within the first 8 to 10 weeks following cutaneous application of the carcinogens 9,10-di-methyl-1,2-benz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	278-281	cyclin-dependent kinase 4	Mus musculus	13-17
12210750-6	2002	We further demonstrated that ERK pathway was involved in PMA-induced steroidogenesis, since PD98059, specific inhibitor of MEK, blocked the increases in steroidogenesis and phosphorylation of ERK caused by PMA, but not by cAMP-PKA.	Tetradecanoylphorbol Acetate	57-60	Eph receptor B1	Rattus norvegicus	192-195
12210750-6	2002	We further demonstrated that ERK pathway was involved in PMA-induced steroidogenesis, since PD98059, specific inhibitor of MEK, blocked the increases in steroidogenesis and phosphorylation of ERK caused by PMA, but not by cAMP-PKA.	Tetradecanoylphorbol Acetate	206-209	Eph receptor B1	Rattus norvegicus	29-32
12210750-6	2002	We further demonstrated that ERK pathway was involved in PMA-induced steroidogenesis, since PD98059, specific inhibitor of MEK, blocked the increases in steroidogenesis and phosphorylation of ERK caused by PMA, but not by cAMP-PKA.	Tetradecanoylphorbol Acetate	206-209	Eph receptor B1	Rattus norvegicus	192-195
12201673-6	2002	In another experiment, yakuchinone A and B reduced production of tumor necrosis factor-alpha in TPA-stimulated mouse skin.	Tetradecanoylphorbol Acetate	96-99	tumor necrosis factor	Mus musculus	65-92
11592962-0	2001	Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.	Tetradecanoylphorbol Acetate	71-107	epidermal growth factor receptor	Homo sapiens	23-55
11592962-2	2001	Recently, TPA was also found to induce epidermal growth factor receptor (EGFR) activity.	Tetradecanoylphorbol Acetate	10-13	epidermal growth factor receptor	Homo sapiens	39-71
11592962-9	2001	Anti-EGFR, anti-heparin-binding EGF, and BB-94 each blocked TPA-induced EGFR phosphorylation, but only anti-EGFR could block EGF-induced EGFR phosphorylation.	Tetradecanoylphorbol Acetate	60-63	epidermal growth factor receptor	Homo sapiens	5-9
11592962-2	2001	Recently, TPA was also found to induce epidermal growth factor receptor (EGFR) activity.	Tetradecanoylphorbol Acetate	10-13	epidermal growth factor receptor	Homo sapiens	73-77
11592962-9	2001	Anti-EGFR, anti-heparin-binding EGF, and BB-94 each blocked TPA-induced EGFR phosphorylation, but only anti-EGFR could block EGF-induced EGFR phosphorylation.	Tetradecanoylphorbol Acetate	60-63	epidermal growth factor receptor	Homo sapiens	72-76
11592962-3	2001	Here, we investigated whether the EGFR is a necessary component for TPA-induced signal transduction associated with tumor promotion.	Tetradecanoylphorbol Acetate	68-71	epidermal growth factor receptor	Homo sapiens	34-38
11592962-9	2001	Anti-EGFR, anti-heparin-binding EGF, and BB-94 each blocked TPA-induced EGFR phosphorylation, but only anti-EGFR could block EGF-induced EGFR phosphorylation.	Tetradecanoylphorbol Acetate	60-63	epidermal growth factor receptor	Homo sapiens	72-76
11592962-9	2001	Anti-EGFR, anti-heparin-binding EGF, and BB-94 each blocked TPA-induced EGFR phosphorylation, but only anti-EGFR could block EGF-induced EGFR phosphorylation.	Tetradecanoylphorbol Acetate	60-63	epidermal growth factor receptor	Homo sapiens	72-76
11592962-4	2001	We demonstrated that potent inhibitors of the EGFR, PD153035 and AG1478, blocked TPA-induced phosphorylation of extracellular signal-regulated kinases (ERKs), AP-1 activity, and cell transformation.	Tetradecanoylphorbol Acetate	81-84	epidermal growth factor receptor	Homo sapiens	46-50
11592962-10	2001	Based on these results, we conclude that the EGFR is required for mediating TPA-induced signal transduction.	Tetradecanoylphorbol Acetate	76-79	epidermal growth factor receptor	Homo sapiens	45-49
11592962-11	2001	EGFR transactivation induced by TPA is a mechanism by which the EGFR mediates TPA-induced tumor promotion-related signal transduction.	Tetradecanoylphorbol Acetate	32-35	epidermal growth factor receptor	Homo sapiens	0-4
11592962-4	2001	We demonstrated that potent inhibitors of the EGFR, PD153035 and AG1478, blocked TPA-induced phosphorylation of extracellular signal-regulated kinases (ERKs), AP-1 activity, and cell transformation.	Tetradecanoylphorbol Acetate	81-84	mitogen-activated protein kinase 1	Homo sapiens	152-156
11592962-11	2001	EGFR transactivation induced by TPA is a mechanism by which the EGFR mediates TPA-induced tumor promotion-related signal transduction.	Tetradecanoylphorbol Acetate	32-35	epidermal growth factor receptor	Homo sapiens	64-68
11592962-5	2001	Egfr gene deficiency blocked TPA-induced ERK activity and AP-1 binding activity.	Tetradecanoylphorbol Acetate	29-32	epidermal growth factor receptor	Homo sapiens	0-4
11592962-11	2001	EGFR transactivation induced by TPA is a mechanism by which the EGFR mediates TPA-induced tumor promotion-related signal transduction.	Tetradecanoylphorbol Acetate	78-81	epidermal growth factor receptor	Homo sapiens	0-4
11592962-11	2001	EGFR transactivation induced by TPA is a mechanism by which the EGFR mediates TPA-induced tumor promotion-related signal transduction.	Tetradecanoylphorbol Acetate	78-81	epidermal growth factor receptor	Homo sapiens	64-68
11592962-5	2001	Egfr gene deficiency blocked TPA-induced ERK activity and AP-1 binding activity.	Tetradecanoylphorbol Acetate	29-32	mitogen-activated protein kinase 1	Homo sapiens	41-44
11592962-6	2001	The blocking of the ectodomain of the EGFR by a monoclonal antibody depressed TPA-induced ERK activity and AP-1 DNA binding activity.	Tetradecanoylphorbol Acetate	78-81	epidermal growth factor receptor	Homo sapiens	38-42
11592962-6	2001	The blocking of the ectodomain of the EGFR by a monoclonal antibody depressed TPA-induced ERK activity and AP-1 DNA binding activity.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 1	Homo sapiens	90-93
11592962-7	2001	The use of a neutralizing antibody for heparin-binding EGF, one of the ligands of EGFR, blocked TPA-induced phosphorylation of ERKs.	Tetradecanoylphorbol Acetate	96-99	epidermal growth factor receptor	Homo sapiens	82-86
11592962-7	2001	The use of a neutralizing antibody for heparin-binding EGF, one of the ligands of EGFR, blocked TPA-induced phosphorylation of ERKs.	Tetradecanoylphorbol Acetate	96-99	mitogen-activated protein kinase 1	Homo sapiens	127-131
11592962-8	2001	BB-94, a potent inhibitor of matrix metalloproteinases, which are activators of ectodomain shedding of EGFR ligands, also blocked TPA-induced ERK activity, AP-1 DNA binding, and cell transformation but had no effect on EGF-induced signal transduction.	Tetradecanoylphorbol Acetate	130-133	epidermal growth factor receptor	Homo sapiens	103-107
11592962-8	2001	BB-94, a potent inhibitor of matrix metalloproteinases, which are activators of ectodomain shedding of EGFR ligands, also blocked TPA-induced ERK activity, AP-1 DNA binding, and cell transformation but had no effect on EGF-induced signal transduction.	Tetradecanoylphorbol Acetate	130-133	mitogen-activated protein kinase 1	Homo sapiens	142-145
11716547-4	2001	We have previously demonstrated that the tumor promoter TPA can induce MMP-9 expression via a third signaling cascade, the p38 pathway.	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase 14	Homo sapiens	123-126
11749964-3	2001	J774 cells overexpressing wild-type Bcl-2 resist oxidant-induced lysosomal leak as well as apoptosis, and this protection is amplified by pretreatment with phorbol 12-myristate 13-acetate (which promotes protein kinase C (PKC)-dependent phosphorylation of Bcl-2).	Tetradecanoylphorbol Acetate	156-187	B cell leukemia/lymphoma 2	Mus musculus	36-41
11749964-3	2001	J774 cells overexpressing wild-type Bcl-2 resist oxidant-induced lysosomal leak as well as apoptosis, and this protection is amplified by pretreatment with phorbol 12-myristate 13-acetate (which promotes protein kinase C (PKC)-dependent phosphorylation of Bcl-2).	Tetradecanoylphorbol Acetate	156-187	B cell leukemia/lymphoma 2	Mus musculus	256-261
11716547-5	2001	Considering that TPA is a potent activator of AP-1, we hypothesized that this transcription factor might also be required for p38 pathway-dependent MMP-9 regulation.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase 14	Homo sapiens	126-129
11728381-4	2001	A recent study (Carcinogenesis 2000;21:1303-12) demonstrated that TPA-treated MCF10A-Neo cells rapidly activate the latent transforming growth factor beta (TGFbeta) in the serum used to supplement the culture medium.	Tetradecanoylphorbol Acetate	66-69	transforming growth factor beta 1	Homo sapiens	123-154
11781828-4	2001	However, RelB degradation differs from that of IkappaBs since it is not induced by TNFalpha but only by T cell receptor or TPA/ionomycin stimulation.	Tetradecanoylphorbol Acetate	123-126	RELB proto-oncogene, NF-kB subunit	Homo sapiens	9-13
11728381-10	2001	These studies demonstrate that TPA initiates protein kinase C-dependent, ERK-independent processes that suppress CYP1A1 activation by TCDD in MCF10A-Neo cells.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 1	Homo sapiens	73-76
11740186-5	2001	MATERIALS AND METHODS: A new technique was developed to detect cytokine expression in phorbol 12-myristate 13-acetate/ionomycin-activated CD62L and alpha4beta7-expressing CD4 T cell subsets, using the protease inhibitor KD-IX-73-4.	Tetradecanoylphorbol Acetate	86-117	CD4 molecule	Homo sapiens	171-174
11704537-6	2001	Secretion of SP-B and SP-C was stimulated three- to fivefold by terbutaline, 5"-(N-ethylcarboxyamido)adenosine, ATP, 12-O-tetradecanoylphorbol 13-acetate, and ionomycin.	Tetradecanoylphorbol Acetate	117-153	surfactant protein C	Rattus norvegicus	22-26
11762949-6	2001	In contrast, splenic lymphocytes (CD3+, CD4+, or CD8+) derived from wild-type and TIA-1-/- mice produced similar amounts of TNFalpha in response to Con A, PMA/ionomycin, or anti-CD3/anti-CD28.	Tetradecanoylphorbol Acetate	155-158	tumor necrosis factor	Mus musculus	124-132
11748674-5	2001	Western blot analysis using Cx43 specific antibodies showed obviously decreasing non phosphorylated Cx43 (P(0)) induced by ELF and/or TPA exposure.	Tetradecanoylphorbol Acetate	134-137	gap junction protein, alpha 1	Mus musculus	28-32
11748674-5	2001	Western blot analysis using Cx43 specific antibodies showed obviously decreasing non phosphorylated Cx43 (P(0)) induced by ELF and/or TPA exposure.	Tetradecanoylphorbol Acetate	134-137	gap junction protein, alpha 1	Mus musculus	100-104
11748674-6	2001	On the other hand, cells treated with ELF and/or TPA displayed a hyperphosphorylated Cx43 band (P(3)).	Tetradecanoylphorbol Acetate	49-52	gap junction protein, alpha 1	Mus musculus	85-89
11728381-4	2001	A recent study (Carcinogenesis 2000;21:1303-12) demonstrated that TPA-treated MCF10A-Neo cells rapidly activate the latent transforming growth factor beta (TGFbeta) in the serum used to supplement the culture medium.	Tetradecanoylphorbol Acetate	66-69	transforming growth factor beta 1	Homo sapiens	156-163
11728381-5	2001	The suppressive effects of TPA on CYP1A1 induction by TCDD in MCF10A-Neo cultures could be partially suppressed by: (a) co-incubation of TCDD + TPA-treated cultures with a neutralizing TGFbeta pan antibody; (b) prior removal of latent TGFbeta from the culture medium; or (c) switching cultures to serum- and growth factor-free medium immediately before the addition of TPA and TCDD.	Tetradecanoylphorbol Acetate	27-30	transforming growth factor beta 1	Homo sapiens	185-192
11728381-5	2001	The suppressive effects of TPA on CYP1A1 induction by TCDD in MCF10A-Neo cultures could be partially suppressed by: (a) co-incubation of TCDD + TPA-treated cultures with a neutralizing TGFbeta pan antibody; (b) prior removal of latent TGFbeta from the culture medium; or (c) switching cultures to serum- and growth factor-free medium immediately before the addition of TPA and TCDD.	Tetradecanoylphorbol Acetate	27-30	transforming growth factor beta 1	Homo sapiens	235-242
11728381-5	2001	The suppressive effects of TPA on CYP1A1 induction by TCDD in MCF10A-Neo cultures could be partially suppressed by: (a) co-incubation of TCDD + TPA-treated cultures with a neutralizing TGFbeta pan antibody; (b) prior removal of latent TGFbeta from the culture medium; or (c) switching cultures to serum- and growth factor-free medium immediately before the addition of TPA and TCDD.	Tetradecanoylphorbol Acetate	144-147	transforming growth factor beta 1	Homo sapiens	185-192
11728381-5	2001	The suppressive effects of TPA on CYP1A1 induction by TCDD in MCF10A-Neo cultures could be partially suppressed by: (a) co-incubation of TCDD + TPA-treated cultures with a neutralizing TGFbeta pan antibody; (b) prior removal of latent TGFbeta from the culture medium; or (c) switching cultures to serum- and growth factor-free medium immediately before the addition of TPA and TCDD.	Tetradecanoylphorbol Acetate	144-147	transforming growth factor beta 1	Homo sapiens	235-242
11728381-5	2001	The suppressive effects of TPA on CYP1A1 induction by TCDD in MCF10A-Neo cultures could be partially suppressed by: (a) co-incubation of TCDD + TPA-treated cultures with a neutralizing TGFbeta pan antibody; (b) prior removal of latent TGFbeta from the culture medium; or (c) switching cultures to serum- and growth factor-free medium immediately before the addition of TPA and TCDD.	Tetradecanoylphorbol Acetate	144-147	transforming growth factor beta 1	Homo sapiens	185-192
11728381-5	2001	The suppressive effects of TPA on CYP1A1 induction by TCDD in MCF10A-Neo cultures could be partially suppressed by: (a) co-incubation of TCDD + TPA-treated cultures with a neutralizing TGFbeta pan antibody; (b) prior removal of latent TGFbeta from the culture medium; or (c) switching cultures to serum- and growth factor-free medium immediately before the addition of TPA and TCDD.	Tetradecanoylphorbol Acetate	144-147	transforming growth factor beta 1	Homo sapiens	235-242
11728381-7	2001	TPA caused a rapid and protracted activation of extracellular signal-regulated kinases (ERKs).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	88-92
11734574-3	2001	We stimulated the MAP kinase pathway with anti-CD3 antibodies and phorbol 12-myristate 13-acetate (PMA), which act upstream of the MAP kinase (MAPK)/ERK kinase (MEK) as U0126, an MEK inhibitor, abolished the actions of these two agents on MAP kinase activation.	Tetradecanoylphorbol Acetate	66-97	mitogen-activated protein kinase kinase 7	Homo sapiens	161-164
11726535-6	2001	Three DAG species significantly curtailed the PMA-induced activation of beta Iota, gamma, and delta, but not of alpha and epsilon, isoforms of PKC.	Tetradecanoylphorbol Acetate	46-49	protein kinase C alpha	Homo sapiens	143-146
11734574-3	2001	We stimulated the MAP kinase pathway with anti-CD3 antibodies and phorbol 12-myristate 13-acetate (PMA), which act upstream of the MAP kinase (MAPK)/ERK kinase (MEK) as U0126, an MEK inhibitor, abolished the actions of these two agents on MAP kinase activation.	Tetradecanoylphorbol Acetate	66-97	mitogen-activated protein kinase kinase 7	Homo sapiens	179-182
11734574-3	2001	We stimulated the MAP kinase pathway with anti-CD3 antibodies and phorbol 12-myristate 13-acetate (PMA), which act upstream of the MAP kinase (MAPK)/ERK kinase (MEK) as U0126, an MEK inhibitor, abolished the actions of these two agents on MAP kinase activation.	Tetradecanoylphorbol Acetate	99-102	mitogen-activated protein kinase kinase 7	Homo sapiens	161-164
11734574-3	2001	We stimulated the MAP kinase pathway with anti-CD3 antibodies and phorbol 12-myristate 13-acetate (PMA), which act upstream of the MAP kinase (MAPK)/ERK kinase (MEK) as U0126, an MEK inhibitor, abolished the actions of these two agents on MAP kinase activation.	Tetradecanoylphorbol Acetate	99-102	mitogen-activated protein kinase kinase 7	Homo sapiens	179-182
11734574-4	2001	EPA and DHA diminished the PMA- and anti-CD3-induced phosphorylation of ERK1/ERK2 in Jurkat T cells.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 3	Homo sapiens	72-76
11734574-4	2001	EPA and DHA diminished the PMA- and anti-CD3-induced phosphorylation of ERK1/ERK2 in Jurkat T cells.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Homo sapiens	77-81
11748375-12	2001	In addition, Rg3 inhibited TPA-stimulated activation of NF-kappaB and extracellular-regulated protein kinase (ERK), one of the mitogen-activated protein (MAP) kinase in mouse skin and also in cultured human breast epithelial cells (MCF-10A).	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Mus musculus	70-108
11731569-14	2001	The phosphorylated ERK1/ERK2 expression following a hypotonic shock was up-regulated by protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) and down-regulated by PKC inhibitor staurosporine.	Tetradecanoylphorbol Acetate	121-152	mitogen-activated protein kinase 3	Homo sapiens	19-23
11748375-12	2001	In addition, Rg3 inhibited TPA-stimulated activation of NF-kappaB and extracellular-regulated protein kinase (ERK), one of the mitogen-activated protein (MAP) kinase in mouse skin and also in cultured human breast epithelial cells (MCF-10A).	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Mus musculus	110-113
11731569-14	2001	The phosphorylated ERK1/ERK2 expression following a hypotonic shock was up-regulated by protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) and down-regulated by PKC inhibitor staurosporine.	Tetradecanoylphorbol Acetate	121-152	mitogen-activated protein kinase 1	Homo sapiens	24-28
11731569-14	2001	The phosphorylated ERK1/ERK2 expression following a hypotonic shock was up-regulated by protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) and down-regulated by PKC inhibitor staurosporine.	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase 3	Homo sapiens	19-23
11731569-14	2001	The phosphorylated ERK1/ERK2 expression following a hypotonic shock was up-regulated by protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) and down-regulated by PKC inhibitor staurosporine.	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase 1	Homo sapiens	24-28
11723253-3	2001	Both agents inhibited the TNF-alpha- or TPA-induced expression of cyclooxygenase (COX)-2 mRNA and protein, COX-2 promoter activity, and prostaglandin E2 (PGE2) production.	Tetradecanoylphorbol Acetate	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-88
11723253-3	2001	Both agents inhibited the TNF-alpha- or TPA-induced expression of cyclooxygenase (COX)-2 mRNA and protein, COX-2 promoter activity, and prostaglandin E2 (PGE2) production.	Tetradecanoylphorbol Acetate	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
11585813-4	2001	We report the induction of IRF-7 expression by 12-O-tetradecanoylphorbol-13-acetate in U937 and HL60 cells and demonstrate that this induction is essential for the monocyte differentiation to macrophages.	Tetradecanoylphorbol Acetate	47-83	interferon regulatory factor 7	Homo sapiens	27-32
11746828-0	2001	Confirmation of the mapping of a 12-O-tetradecanoylphorbol-13-acetate promotion susceptibility locus, Psl1, to distal mouse chromosome 9.	Tetradecanoylphorbol Acetate	33-69	promotion susceptibility QTL 1	Mus musculus	102-106
11746828-3	2001	One TPA susceptibility locus, Psl1, previously was mapped to distal chromosome 9.	Tetradecanoylphorbol Acetate	4-7	promotion susceptibility QTL 1	Mus musculus	30-34
11746828-5	2001	Furthermore, Psl1 or a gene closely linked to Psl1 influenced epidermal hyperplasia and epidermal labeling index of mice treated with TPA.	Tetradecanoylphorbol Acetate	134-137	promotion susceptibility QTL 1	Mus musculus	13-17
11746828-5	2001	Furthermore, Psl1 or a gene closely linked to Psl1 influenced epidermal hyperplasia and epidermal labeling index of mice treated with TPA.	Tetradecanoylphorbol Acetate	134-137	promotion susceptibility QTL 1	Mus musculus	46-50
11746831-4	2001	By using this vector and specific neutralizing monoclonal antibodies (mAbs), it was established that PMA-induced apoptosis also called for an interaction between cell-surface alpha(5)beta(1)-integrin and its deposited ligand fibronectin (FN), which is downstream of PKC-beta activation.	Tetradecanoylphorbol Acetate	101-104	fibronectin 1	Homo sapiens	225-236
11746831-4	2001	By using this vector and specific neutralizing monoclonal antibodies (mAbs), it was established that PMA-induced apoptosis also called for an interaction between cell-surface alpha(5)beta(1)-integrin and its deposited ligand fibronectin (FN), which is downstream of PKC-beta activation.	Tetradecanoylphorbol Acetate	101-104	fibronectin 1	Homo sapiens	238-240
11707282-4	2001	On the other hand, PKCbeta inhibition suppressed the TPA-stimulated increase in neuropeptide Y mRNA, activation of neuropeptide Y gene promoter elements, and phosphorylation of Erk1/2.	Tetradecanoylphorbol Acetate	53-56	mitogen-activated protein kinase 3	Homo sapiens	177-183
11581255-8	2001	Specific activation of PKC with 12-O-tetradecanoylphorbol-13-acetate or bryostatin-1 induced translocation of PKC from the cytosol to the membrane and effectively inhibited cell shrinkage and cell death triggered by anti-Fas antibody in Jurkat cells.	Tetradecanoylphorbol Acetate	32-68	proline rich transmembrane protein 2	Homo sapiens	23-26
11581255-8	2001	Specific activation of PKC with 12-O-tetradecanoylphorbol-13-acetate or bryostatin-1 induced translocation of PKC from the cytosol to the membrane and effectively inhibited cell shrinkage and cell death triggered by anti-Fas antibody in Jurkat cells.	Tetradecanoylphorbol Acetate	32-68	proline rich transmembrane protein 2	Homo sapiens	110-113
11719466-6	2001	Furthermore, hypoxia increased the transcriptional activity of a 12-O-tetradecanoylphorbol-13-acetate response element-like motif on the GRP78 promoter and increased the abundance and DNA binding activity of AP-1 complex composed of c-Jun and c-Fos.	Tetradecanoylphorbol Acetate	65-101	heat shock protein family A (Hsp70) member 5	Homo sapiens	137-142
11719466-10	2001	Taken together, this study shows that a PKC-epsilon-Raf-1-MEK-ERK-AP1 signaling cascade acts on a 12-O-tetradecanoylphorbol-13-acetate response element-like element to mediate hypoxia-induced GRP78 expression in human gastric cancer cells.	Tetradecanoylphorbol Acetate	98-134	mitogen-activated protein kinase kinase 7	Homo sapiens	58-61
11719466-10	2001	Taken together, this study shows that a PKC-epsilon-Raf-1-MEK-ERK-AP1 signaling cascade acts on a 12-O-tetradecanoylphorbol-13-acetate response element-like element to mediate hypoxia-induced GRP78 expression in human gastric cancer cells.	Tetradecanoylphorbol Acetate	98-134	mitogen-activated protein kinase 1	Homo sapiens	62-65
11719466-10	2001	Taken together, this study shows that a PKC-epsilon-Raf-1-MEK-ERK-AP1 signaling cascade acts on a 12-O-tetradecanoylphorbol-13-acetate response element-like element to mediate hypoxia-induced GRP78 expression in human gastric cancer cells.	Tetradecanoylphorbol Acetate	98-134	heat shock protein family A (Hsp70) member 5	Homo sapiens	192-197
11719467-8	2001	A positive regulatory mechanism for TGFbetaRII expression in a TGF-beta-expressing cell line was also investigated, and a TPA-responsive element (TRE)-like motif, TRE2, was detected in addition to the previously reported TRE-like motif Y element in the positive regulatory region.	Tetradecanoylphorbol Acetate	122-125	transforming growth factor beta 1	Homo sapiens	63-71
11557763-1	2001	We show that tumor necrosis factor (TNF) and phorbol 12-myristate 13-acetate (PMA) induce TNF-related apoptosis-inducing ligand (TRAIL) in T cells.	Tetradecanoylphorbol Acetate	45-76	TNF superfamily member 10	Homo sapiens	90-127
11557763-1	2001	We show that tumor necrosis factor (TNF) and phorbol 12-myristate 13-acetate (PMA) induce TNF-related apoptosis-inducing ligand (TRAIL) in T cells.	Tetradecanoylphorbol Acetate	45-76	TNF superfamily member 10	Homo sapiens	129-134
11557763-1	2001	We show that tumor necrosis factor (TNF) and phorbol 12-myristate 13-acetate (PMA) induce TNF-related apoptosis-inducing ligand (TRAIL) in T cells.	Tetradecanoylphorbol Acetate	78-81	tumor necrosis factor	Homo sapiens	13-34
11557763-1	2001	We show that tumor necrosis factor (TNF) and phorbol 12-myristate 13-acetate (PMA) induce TNF-related apoptosis-inducing ligand (TRAIL) in T cells.	Tetradecanoylphorbol Acetate	78-81	TNF superfamily member 10	Homo sapiens	90-127
11557763-1	2001	We show that tumor necrosis factor (TNF) and phorbol 12-myristate 13-acetate (PMA) induce TNF-related apoptosis-inducing ligand (TRAIL) in T cells.	Tetradecanoylphorbol Acetate	78-81	TNF superfamily member 10	Homo sapiens	129-134
11700037-3	2001	In isolated CD4+CD8+CCR7-thymocytes, a moderate 20-h pulse stimulation with a combination of the calcium ionophore ionomycin and the protein kinase C activator phorbol myristate acetate induced CCR7 expression and CD8 downregulation.	Tetradecanoylphorbol Acetate	160-185	CD4 molecule	Homo sapiens	12-15
11700037-3	2001	In isolated CD4+CD8+CCR7-thymocytes, a moderate 20-h pulse stimulation with a combination of the calcium ionophore ionomycin and the protein kinase C activator phorbol myristate acetate induced CCR7 expression and CD8 downregulation.	Tetradecanoylphorbol Acetate	160-185	C-C motif chemokine receptor 7	Homo sapiens	20-24
11700037-3	2001	In isolated CD4+CD8+CCR7-thymocytes, a moderate 20-h pulse stimulation with a combination of the calcium ionophore ionomycin and the protein kinase C activator phorbol myristate acetate induced CCR7 expression and CD8 downregulation.	Tetradecanoylphorbol Acetate	160-185	C-C motif chemokine receptor 7	Homo sapiens	194-198
11707282-5	2001	The TPA-induced increase in neuropeptide Y expression was also inhibited by the MEK inhibitor PD98059.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase kinase 7	Homo sapiens	80-83
11714372-8	2001	After stimulation by PMA, a dose-dependent inhibition of AP-1 was observed with the six phenolic acids in the 20 nM-20 microM concentration range: gallic acid &gt; caffeic &gt; protocatechic, paracoumaric, sinapic acids &gt; ferulic acid.	Tetradecanoylphorbol Acetate	21-24	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-61
11701468-2	2001	Recently, we have identified a novel macrophage cell-surface receptor for Ox-LDL by expression cloning from a cDNA library of phorbol 12-myristate 13-acetate-stimulated THP-1 cells, designated as the scavenger receptor for phosphatidylserine and oxidized lipoprotein (SR-PSOX).	Tetradecanoylphorbol Acetate	126-157	C-X-C motif chemokine ligand 16	Homo sapiens	200-266
11701468-2	2001	Recently, we have identified a novel macrophage cell-surface receptor for Ox-LDL by expression cloning from a cDNA library of phorbol 12-myristate 13-acetate-stimulated THP-1 cells, designated as the scavenger receptor for phosphatidylserine and oxidized lipoprotein (SR-PSOX).	Tetradecanoylphorbol Acetate	126-157	C-X-C motif chemokine ligand 16	Homo sapiens	268-275
11675357-3	2001	Furthermore, the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate, which stimulates sphingosine kinase, the enzyme responsible for S-1P production, also inhibits cytochrome c and Smac/DIABLO release.	Tetradecanoylphorbol Acetate	32-69	cytochrome c, somatic	Homo sapiens	166-178
11696049-6	2001	RESULTS: We show that while piceatannol has an IC50 for inhibition of IgE-mediated histamine release of 3-5 microm, these same concentrations inhibit secretion of phorbol 12-myristate 13-acetate (PMA)-induced histamine release (as previously shown) and leukotriene C (LTC)4 release induced by fMLP.	Tetradecanoylphorbol Acetate	163-194	formyl peptide receptor 1	Homo sapiens	293-297
11703361-6	2001	As expected, CD8+ T lymphocytes from peripheral blood of healthy volunteers produced significantly more IFN-gamma in the presence of PMA and calcium-ionophore than after stimulation with anti-CD3 antibodies.	Tetradecanoylphorbol Acetate	133-136	interferon gamma	Homo sapiens	104-113
11703361-7	2001	However, in subjects with allergic asthma, IFN-gamma secretion of CD8+ T cells was significantly higher when incubated with anti-CD3 antibodies than after activation with PMA and calcium-ionophore.	Tetradecanoylphorbol Acetate	171-174	interferon gamma	Homo sapiens	43-52
11703361-8	2001	While IFN-gamma secretion of CD8+ T lymphocytes of patients with allergic asthma was lower than that of healthy controls in the presence of PMA/calcium-ionophore, it was significantly elevated when compared with normal controls after stimulation with anti-CD3 antibodies.	Tetradecanoylphorbol Acetate	140-143	interferon gamma	Homo sapiens	6-15
11600479-11	2001	The cause of Behcet"s syndrome is unknown but peripheral blood CD45 gammadelta T cells in Behcet"s produce &gt;50-fold more TNF-alpha than controls when stimulated with phorbol myristate acetate and anti-CD3.	Tetradecanoylphorbol Acetate	169-194	tumor necrosis factor	Homo sapiens	124-133
11598902-4	2001	Inhibition was also effected by phorbol myristoyl acetate (PMA), which reduced the rate of EGFR tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	59-62	epidermal growth factor receptor	Homo sapiens	91-95
11600418-5	2001	The mRNA levels of the NHE isoforms in Caco-2 cells were initially measured by a semiquantitative RT-PCR technique in response to PKC downregulation by long-term exposure to 1 microM 12-O-tetradecanoylphorbol-13-acetate (TPA) for 24 h. PKC downregulation resulted in an approximately 60% increase in the mRNA level for NHE3, but not for NHE1 or NHE2.	Tetradecanoylphorbol Acetate	183-219	protein kinase C alpha	Homo sapiens	130-133
11600418-5	2001	The mRNA levels of the NHE isoforms in Caco-2 cells were initially measured by a semiquantitative RT-PCR technique in response to PKC downregulation by long-term exposure to 1 microM 12-O-tetradecanoylphorbol-13-acetate (TPA) for 24 h. PKC downregulation resulted in an approximately 60% increase in the mRNA level for NHE3, but not for NHE1 or NHE2.	Tetradecanoylphorbol Acetate	221-224	protein kinase C alpha	Homo sapiens	130-133
11600418-7	2001	Consistent with the mRNA results, our data showed that amiloride-sensitive (22)Na(+) uptake was increased after incubation of Caco-2 cells with 1 microM TPA for 24 h. To elucidate the role of PKC-alpha, an isoform downregulated by TPA, the relative abundance of NHE isoform mRNA levels and the apical NHE activity were assessed in Caco-2 cells over- and underexpressing PKC-alpha.	Tetradecanoylphorbol Acetate	153-156	protein kinase C alpha	Homo sapiens	192-201
11600418-7	2001	Consistent with the mRNA results, our data showed that amiloride-sensitive (22)Na(+) uptake was increased after incubation of Caco-2 cells with 1 microM TPA for 24 h. To elucidate the role of PKC-alpha, an isoform downregulated by TPA, the relative abundance of NHE isoform mRNA levels and the apical NHE activity were assessed in Caco-2 cells over- and underexpressing PKC-alpha.	Tetradecanoylphorbol Acetate	153-156	protein kinase C alpha	Homo sapiens	370-379
11602666-5	2001	In contrast, the PKC activator phorbol-12-myristate-13-acetate (PMA) suppressed the uptake mediated by rat oatp1 and oatp2 in a concentration- and time-dependent manner.	Tetradecanoylphorbol Acetate	31-62	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	107-112
11602666-5	2001	In contrast, the PKC activator phorbol-12-myristate-13-acetate (PMA) suppressed the uptake mediated by rat oatp1 and oatp2 in a concentration- and time-dependent manner.	Tetradecanoylphorbol Acetate	64-67	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	107-112
11602672-7	2001	The effects were mimicked by 10 nM phorbol-12-myristate-13-acetate, a PKC activator, but attenuated by 5 microM chelerythrine, a PKC inhibitor.	Tetradecanoylphorbol Acetate	35-66	protein kinase C, epsilon	Rattus norvegicus	70-73
11641439-0	2001	Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK).	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 1	Homo sapiens	240-243
11691580-10	2001	Inhibiting TPA-inducible PKC did not affect any MMP in RCG except MMP-13, which was strongly induced.	Tetradecanoylphorbol Acetate	11-14	proline rich transmembrane protein 2	Homo sapiens	25-28
11641439-10	2001	We propose that, in HASMC, PMA activates PDE4D5 through an ERK-controlled autocrine mechanism.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Homo sapiens	59-62
11641439-3	2001	PMA elicited an inhibitory effect on PDE4D5 activity in HASMC treated with the cyclooxygenase (COX) inhibitor indomethacin, the COX-2 selective inhibitor NS-398, the phospholipase A(2) inhibitor quinacrine, and the cAMP-dependent protein kinase A (PKA) inhibitor H89.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
11602182-6	2001	Signalling to ERK activation by FCS, phorbol 12-myristate 13-acetate (PMA) and platelet-derived growth factor (PDGF) was similarly blocked.	Tetradecanoylphorbol Acetate	37-68	mitogen-activated protein kinase 1	Homo sapiens	14-17
11710520-8	2001	Up-regulation of protein kinase C by a 2 h preincubation with phorbol 12-myristate 13-acetate increased the EA4-dependent expression of the Cyp1a1 gene.	Tetradecanoylphorbol Acetate	62-93	erythrocyte antigen 4	Mus musculus	108-111
11583584-8	2001	PMA also caused the rapid activation of MAPK and the phosphorylation of GATA-4.	Tetradecanoylphorbol Acetate	0-3	GATA binding protein 4	Mus musculus	72-78
11563987-6	2001	Given that LPA could prevent adhesion for cells maintained in the serum-free medium, here we propose that RhoA has a switching role in determining whether TF-1 and D2 cells undergo differentiation or apoptosis in response to PMA, by modulating cell adhesion.	Tetradecanoylphorbol Acetate	225-228	ras homolog family member A	Homo sapiens	106-110
11693999-1	2001	In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors.	Tetradecanoylphorbol Acetate	108-133	interferon gamma	Homo sapiens	50-59
11693999-1	2001	In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors.	Tetradecanoylphorbol Acetate	108-133	interleukin 4	Homo sapiens	65-78
11693999-1	2001	In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors.	Tetradecanoylphorbol Acetate	108-133	interleukin 4	Homo sapiens	80-84
11693999-1	2001	In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors.	Tetradecanoylphorbol Acetate	135-138	interferon gamma	Homo sapiens	32-48
11693999-1	2001	In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors.	Tetradecanoylphorbol Acetate	135-138	interferon gamma	Homo sapiens	50-59
11693999-1	2001	In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors.	Tetradecanoylphorbol Acetate	135-138	interleukin 4	Homo sapiens	65-78
11693999-1	2001	In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors.	Tetradecanoylphorbol Acetate	135-138	interleukin 4	Homo sapiens	80-84
11682062-4	2001	Luciferase gene reporter assays revealed that cPrG.HCl potently suppressed the TNFalpha- and the phorbol myristate acetate-induced activation of NF-kappaB.	Tetradecanoylphorbol Acetate	97-122	nuclear factor kappa B subunit 1	Homo sapiens	145-154
11682064-7	2001	In addition, the tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid stimulated the association of phosphorylated histone H3 on serine 10 with the HER2 promoter and also stimulated HER2 expression.	Tetradecanoylphorbol Acetate	33-69	erb-b2 receptor tyrosine kinase 2	Homo sapiens	165-169
11682064-7	2001	In addition, the tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid stimulated the association of phosphorylated histone H3 on serine 10 with the HER2 promoter and also stimulated HER2 expression.	Tetradecanoylphorbol Acetate	33-69	erb-b2 receptor tyrosine kinase 2	Homo sapiens	199-203
11591766-5	2001	The cell type specificity of the minimal IL-13 promoter is mediated by a functionally critical GATA-3 site that binds endogenous GATA-3 proteins, whereas the induction by PMA/ionomycin is mediated by distinct cis-acting elements.	Tetradecanoylphorbol Acetate	171-174	interleukin 13	Mus musculus	41-46
11495925-6	2001	We show that the cleavage of fractalkine can be markedly enhanced by stimulating cells with phorbol 12-myristate 13-acetate (PMA), and we identify tumor necrosis factor-alpha converting enzyme (TACE; ADAM17) as the protease responsible for this PMA-induced fractalkine release.	Tetradecanoylphorbol Acetate	92-123	C-X3-C motif chemokine ligand 1	Homo sapiens	29-40
11495925-6	2001	We show that the cleavage of fractalkine can be markedly enhanced by stimulating cells with phorbol 12-myristate 13-acetate (PMA), and we identify tumor necrosis factor-alpha converting enzyme (TACE; ADAM17) as the protease responsible for this PMA-induced fractalkine release.	Tetradecanoylphorbol Acetate	125-128	C-X3-C motif chemokine ligand 1	Homo sapiens	29-40
11495925-6	2001	We show that the cleavage of fractalkine can be markedly enhanced by stimulating cells with phorbol 12-myristate 13-acetate (PMA), and we identify tumor necrosis factor-alpha converting enzyme (TACE; ADAM17) as the protease responsible for this PMA-induced fractalkine release.	Tetradecanoylphorbol Acetate	245-248	C-X3-C motif chemokine ligand 1	Homo sapiens	29-40
11709711-7	2001	Inhibition of PKC by GF109203 or H7 counteracted the TPA-mediated effects on the cleavage of caspases -3 and -8.	Tetradecanoylphorbol Acetate	53-56	proline rich transmembrane protein 2	Homo sapiens	14-17
11709711-7	2001	Inhibition of PKC by GF109203 or H7 counteracted the TPA-mediated effects on the cleavage of caspases -3 and -8.	Tetradecanoylphorbol Acetate	53-56	caspase 3	Homo sapiens	93-111
11693999-1	2001	In this study, we report on the interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) cytokine responses to phorbol myristate acetate (PMA) + ionomycin-stimulated CD3+ lymphocytes in asthmatic subjects when compared with normal donors.	Tetradecanoylphorbol Acetate	108-133	interferon gamma	Homo sapiens	32-48
11591175-0	2001	p21(WAF1) is associated with CDK2 and CDK4 protein during HL-60 cell differentiation by TPA treatment.	Tetradecanoylphorbol Acetate	88-91	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-3
11591175-0	2001	p21(WAF1) is associated with CDK2 and CDK4 protein during HL-60 cell differentiation by TPA treatment.	Tetradecanoylphorbol Acetate	88-91	cyclin dependent kinase inhibitor 1A	Homo sapiens	4-8
11591175-1	2001	TPA-treated HL-60 cells are mainly arrested in G1 by p21(WAF1) accumulation.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	53-56
11591175-1	2001	TPA-treated HL-60 cells are mainly arrested in G1 by p21(WAF1) accumulation.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	57-61
11602182-6	2001	Signalling to ERK activation by FCS, phorbol 12-myristate 13-acetate (PMA) and platelet-derived growth factor (PDGF) was similarly blocked.	Tetradecanoylphorbol Acetate	70-73	mitogen-activated protein kinase 1	Homo sapiens	14-17
11678905-4	2001	Following re-stimulation in vitro with PMA and ionomycin, CD4+ T cells produced IFNgamma, TNFalpha, TNFbeta, IL-2, IL-4, IL-10 and IL-13.	Tetradecanoylphorbol Acetate	39-42	CD4 molecule	Homo sapiens	58-61
11553022-8	2001	Incubation with phorbol 12-myristate 13-acetate, the PKC activator, enhanced the increase in Mn-SOD gene expression in response to transient hypoxia.	Tetradecanoylphorbol Acetate	16-47	proline rich transmembrane protein 2	Homo sapiens	53-56
11564869-5	2001	Primary lymphocytes from HePTP(-/-) mice show enhanced activation of extracellular stimulus-regulated kinase (ERK) after both phorbol myristate acetate (PMA) and anti-CD3-mediated T-cell receptor (TCR) stimulation, suggesting a true physiological relationship between these two molecules.	Tetradecanoylphorbol Acetate	126-151	mitogen-activated protein kinase 1	Mus musculus	69-108
11720817-4	2001	Incubation of MNC with 50 U ml(-1) of IL-13 for 2 h significantly enhanced superoxide anion production in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	118-143	interleukin 13	Homo sapiens	38-43
11668484-5	2001	Our results show that combined treatment with IFN-gamma and RA or the phorbol ester 12-O-tetradecanoyl-phorbol acetate (TPA) had synergistic or enhancing effects on morphologic differentiation and neurite outgrowth in 5 of 5 neuroblastoma cell lines, 3 of which expressed very high levels of N-myc mRNA due to N-myc amplification.	Tetradecanoylphorbol Acetate	84-118	plasminogen activator, tissue type	Homo sapiens	120-123
11678905-4	2001	Following re-stimulation in vitro with PMA and ionomycin, CD4+ T cells produced IFNgamma, TNFalpha, TNFbeta, IL-2, IL-4, IL-10 and IL-13.	Tetradecanoylphorbol Acetate	39-42	interferon gamma	Homo sapiens	80-88
11678905-4	2001	Following re-stimulation in vitro with PMA and ionomycin, CD4+ T cells produced IFNgamma, TNFalpha, TNFbeta, IL-2, IL-4, IL-10 and IL-13.	Tetradecanoylphorbol Acetate	39-42	tumor necrosis factor	Homo sapiens	90-98
11678905-4	2001	Following re-stimulation in vitro with PMA and ionomycin, CD4+ T cells produced IFNgamma, TNFalpha, TNFbeta, IL-2, IL-4, IL-10 and IL-13.	Tetradecanoylphorbol Acetate	39-42	interleukin 2	Homo sapiens	109-113
11678905-4	2001	Following re-stimulation in vitro with PMA and ionomycin, CD4+ T cells produced IFNgamma, TNFalpha, TNFbeta, IL-2, IL-4, IL-10 and IL-13.	Tetradecanoylphorbol Acetate	39-42	interleukin 4	Homo sapiens	115-119
11678905-4	2001	Following re-stimulation in vitro with PMA and ionomycin, CD4+ T cells produced IFNgamma, TNFalpha, TNFbeta, IL-2, IL-4, IL-10 and IL-13.	Tetradecanoylphorbol Acetate	39-42	interleukin 13	Homo sapiens	131-136
11678905-8	2001	When CD4+ T cells were re-stimulated using autologous LCL as antigen-presenting cells, they produced more IL-4 and less IFNgamma or IL-13 when compared with cells re-stimulated by phorbol myristate acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	207-210	CD4 molecule	Homo sapiens	5-8
11685264-5	2001	M. leprae was able, however, to induce TNF-alpha secretion both in blood-derived monocytes as well as in THP-1 cells pretreated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	133-158	tumor necrosis factor	Homo sapiens	39-48
11746822-2	2001	In this report, we show that Drg-1 was expressed in keratinocytes, this expression being rapidly increased as a result of induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) or the presence of an activating form of Ha-ras.	Tetradecanoylphorbol Acetate	135-171	developmentally regulated GTP binding protein 1	Mus musculus	29-34
11564869-5	2001	Primary lymphocytes from HePTP(-/-) mice show enhanced activation of extracellular stimulus-regulated kinase (ERK) after both phorbol myristate acetate (PMA) and anti-CD3-mediated T-cell receptor (TCR) stimulation, suggesting a true physiological relationship between these two molecules.	Tetradecanoylphorbol Acetate	126-151	mitogen-activated protein kinase 1	Mus musculus	110-113
11564869-5	2001	Primary lymphocytes from HePTP(-/-) mice show enhanced activation of extracellular stimulus-regulated kinase (ERK) after both phorbol myristate acetate (PMA) and anti-CD3-mediated T-cell receptor (TCR) stimulation, suggesting a true physiological relationship between these two molecules.	Tetradecanoylphorbol Acetate	153-156	mitogen-activated protein kinase 1	Mus musculus	69-108
11564869-5	2001	Primary lymphocytes from HePTP(-/-) mice show enhanced activation of extracellular stimulus-regulated kinase (ERK) after both phorbol myristate acetate (PMA) and anti-CD3-mediated T-cell receptor (TCR) stimulation, suggesting a true physiological relationship between these two molecules.	Tetradecanoylphorbol Acetate	153-156	mitogen-activated protein kinase 1	Mus musculus	110-113
11605784-4	2001	NF-kappaB and AP-1 DNA-binding abilities were significantly increased both at baseline and after stimulation by phorbol 12-myristate 13-acetate (TPA) in PBMC from MCNS patients compared with controls, but declined to normal levels after treatment with dexamethasone (DEX).	Tetradecanoylphorbol Acetate	145-148	nuclear factor kappa B subunit 1	Homo sapiens	0-9
11746822-2	2001	In this report, we show that Drg-1 was expressed in keratinocytes, this expression being rapidly increased as a result of induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) or the presence of an activating form of Ha-ras.	Tetradecanoylphorbol Acetate	173-176	developmentally regulated GTP binding protein 1	Mus musculus	29-34
11746822-4	2001	Overexpression of Drg-1 was also observed in TPA-induced hyperplastic skin.	Tetradecanoylphorbol Acetate	45-48	developmentally regulated GTP binding protein 1	Mus musculus	18-23
11605784-4	2001	NF-kappaB and AP-1 DNA-binding abilities were significantly increased both at baseline and after stimulation by phorbol 12-myristate 13-acetate (TPA) in PBMC from MCNS patients compared with controls, but declined to normal levels after treatment with dexamethasone (DEX).	Tetradecanoylphorbol Acetate	112-143	nuclear factor kappa B subunit 1	Homo sapiens	0-9
11605784-4	2001	NF-kappaB and AP-1 DNA-binding abilities were significantly increased both at baseline and after stimulation by phorbol 12-myristate 13-acetate (TPA) in PBMC from MCNS patients compared with controls, but declined to normal levels after treatment with dexamethasone (DEX).	Tetradecanoylphorbol Acetate	112-143	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-18
11605784-4	2001	NF-kappaB and AP-1 DNA-binding abilities were significantly increased both at baseline and after stimulation by phorbol 12-myristate 13-acetate (TPA) in PBMC from MCNS patients compared with controls, but declined to normal levels after treatment with dexamethasone (DEX).	Tetradecanoylphorbol Acetate	145-148	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-18
11605784-5	2001	GR DNA-binding abilities were significantly reduced at baseline and after treatment with TPA, but were enhanced markedly by DEX.	Tetradecanoylphorbol Acetate	89-92	nuclear receptor subfamily 3 group C member 1	Homo sapiens	0-2
11642546-4	2001	In contrast, PMA showed just the opposite effects on the TSP-1 expression in the same cells.	Tetradecanoylphorbol Acetate	13-16	thrombospondin 1	Homo sapiens	57-62
11563864-3	2001	Using a model of human promonocytic cells (THP-1), the cells were differentiated into macrophages by preincubation with C. pneumoniae extract, and further stimulated by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	169-194	GLI family zinc finger 2	Homo sapiens	43-48
11583819-4	2001	Moreover, Bge cell treatment with inhibitors of protein kinase C (PKC), Ras and MAPK kinase (Mek) suppressed PMA-induced expression of activated MAPK, suggesting that PKC-, Ras- and Mek-like molecules may be acting upstream of MAPK.	Tetradecanoylphorbol Acetate	109-112	proline rich transmembrane protein 2	Homo sapiens	48-64
11770418-5	2001	PMA, an agonist of PKC could reduce the expression of cNOS mNRA in hypoxia, while RO 31-8220, an inhibitor of PKC could inhibit it and enhance the expression of NOS mRNA(P &lt; 0.01).	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	19-22
11770418-5	2001	PMA, an agonist of PKC could reduce the expression of cNOS mNRA in hypoxia, while RO 31-8220, an inhibitor of PKC could inhibit it and enhance the expression of NOS mRNA(P &lt; 0.01).	Tetradecanoylphorbol Acetate	0-3	nitric oxide synthase 3	Homo sapiens	54-58
11583819-4	2001	Moreover, Bge cell treatment with inhibitors of protein kinase C (PKC), Ras and MAPK kinase (Mek) suppressed PMA-induced expression of activated MAPK, suggesting that PKC-, Ras- and Mek-like molecules may be acting upstream of MAPK.	Tetradecanoylphorbol Acetate	109-112	proline rich transmembrane protein 2	Homo sapiens	66-69
11583819-4	2001	Moreover, Bge cell treatment with inhibitors of protein kinase C (PKC), Ras and MAPK kinase (Mek) suppressed PMA-induced expression of activated MAPK, suggesting that PKC-, Ras- and Mek-like molecules may be acting upstream of MAPK.	Tetradecanoylphorbol Acetate	109-112	mitogen-activated protein kinase kinase 7	Homo sapiens	93-96
11766607-5	2001	RESULTS: 100 ng/ml PMA significantly increased VEGF mRNA expression, intracellular production and secretion of VEGF in endothelial cells, while triptolide inhibited the effects of PMA in a dose-dependent manner.	Tetradecanoylphorbol Acetate	19-22	vascular endothelial growth factor A	Homo sapiens	47-51
11583819-4	2001	Moreover, Bge cell treatment with inhibitors of protein kinase C (PKC), Ras and MAPK kinase (Mek) suppressed PMA-induced expression of activated MAPK, suggesting that PKC-, Ras- and Mek-like molecules may be acting upstream of MAPK.	Tetradecanoylphorbol Acetate	109-112	proline rich transmembrane protein 2	Homo sapiens	167-170
11549266-7	2001	Moreover, PMA (phorbol myristate acetate), PKC (protein kinase C) activator, protected U937 cells from okadaic acid-induced apoptosis, abrogated okadaic acid-induced caspase 3 activation, and specifically inhibited downregulation of XIAP (X-linked inhibitor of apoptosis) by okadaic acid.	Tetradecanoylphorbol Acetate	15-40	caspase 3	Homo sapiens	166-175
11583819-4	2001	Moreover, Bge cell treatment with inhibitors of protein kinase C (PKC), Ras and MAPK kinase (Mek) suppressed PMA-induced expression of activated MAPK, suggesting that PKC-, Ras- and Mek-like molecules may be acting upstream of MAPK.	Tetradecanoylphorbol Acetate	109-112	mitogen-activated protein kinase kinase 7	Homo sapiens	182-185
11448957-8	2001	Inhibition of CCR5 palmitoylation by alanine mutagenesis of cysteines or treatment with a palmitate analogue inhibitor profoundly reduces phorbol 12-myristate 13-acetate- and RANTES-induced receptor phosphorylation, homologous desensitization, and internalization.	Tetradecanoylphorbol Acetate	138-169	C-C motif chemokine receptor 5	Rattus norvegicus	14-18
11766607-5	2001	RESULTS: 100 ng/ml PMA significantly increased VEGF mRNA expression, intracellular production and secretion of VEGF in endothelial cells, while triptolide inhibited the effects of PMA in a dose-dependent manner.	Tetradecanoylphorbol Acetate	19-22	vascular endothelial growth factor A	Homo sapiens	111-115
11544302-6	2001	Treatment with TCR mimetics (PMA/ionomycin, PHA, and anti-CD3/CD28 Abs) resulted in a rapid increase in the expression of TRAIL mRNA and cell surface TRAIL protein.	Tetradecanoylphorbol Acetate	29-32	TNF superfamily member 10	Homo sapiens	122-127
11544302-6	2001	Treatment with TCR mimetics (PMA/ionomycin, PHA, and anti-CD3/CD28 Abs) resulted in a rapid increase in the expression of TRAIL mRNA and cell surface TRAIL protein.	Tetradecanoylphorbol Acetate	29-32	TNF superfamily member 10	Homo sapiens	150-155
11432874-1	2001	Results from our previous study suggest that cyclooxygenase-2 (COX-2) induced by phorbol 12-myristate 13-acetate (PMA) may be localized to caveolae-like structures (Liou, J.-Y., Shyue, S.-K., Tsai, M.-J., Chung, C.-L., Chu, K.-Y., and Wu, K. K. (2000) J. Biol.	Tetradecanoylphorbol Acetate	81-112	prostaglandin-endoperoxide synthase 2	Homo sapiens	45-61
11432874-1	2001	Results from our previous study suggest that cyclooxygenase-2 (COX-2) induced by phorbol 12-myristate 13-acetate (PMA) may be localized to caveolae-like structures (Liou, J.-Y., Shyue, S.-K., Tsai, M.-J., Chung, C.-L., Chu, K.-Y., and Wu, K. K. (2000) J. Biol.	Tetradecanoylphorbol Acetate	81-112	prostaglandin-endoperoxide synthase 2	Homo sapiens	63-68
11432874-1	2001	Results from our previous study suggest that cyclooxygenase-2 (COX-2) induced by phorbol 12-myristate 13-acetate (PMA) may be localized to caveolae-like structures (Liou, J.-Y., Shyue, S.-K., Tsai, M.-J., Chung, C.-L., Chu, K.-Y., and Wu, K. K. (2000) J. Biol.	Tetradecanoylphorbol Acetate	114-117	prostaglandin-endoperoxide synthase 2	Homo sapiens	45-61
11432874-1	2001	Results from our previous study suggest that cyclooxygenase-2 (COX-2) induced by phorbol 12-myristate 13-acetate (PMA) may be localized to caveolae-like structures (Liou, J.-Y., Shyue, S.-K., Tsai, M.-J., Chung, C.-L., Chu, K.-Y., and Wu, K. K. (2000) J. Biol.	Tetradecanoylphorbol Acetate	114-117	prostaglandin-endoperoxide synthase 2	Homo sapiens	63-68
11549266-7	2001	Moreover, PMA (phorbol myristate acetate), PKC (protein kinase C) activator, protected U937 cells from okadaic acid-induced apoptosis, abrogated okadaic acid-induced caspase 3 activation, and specifically inhibited downregulation of XIAP (X-linked inhibitor of apoptosis) by okadaic acid.	Tetradecanoylphorbol Acetate	10-13	caspase 3	Homo sapiens	166-175
11549266-9	2001	In addition, these findings indicate that PMA inhibits okadaic acid-induced apoptosis by a mechanism that interferes with cytochrome c release and activity of caspase 3 that is involved in the execution of apoptosis.	Tetradecanoylphorbol Acetate	42-45	cytochrome c, somatic	Homo sapiens	122-134
11549266-9	2001	In addition, these findings indicate that PMA inhibits okadaic acid-induced apoptosis by a mechanism that interferes with cytochrome c release and activity of caspase 3 that is involved in the execution of apoptosis.	Tetradecanoylphorbol Acetate	42-45	caspase 3	Homo sapiens	159-168
11669302-9	2001	PKC alpha was the only isoform that translocated to the membrane upon stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	87-112	protein kinase C alpha	Homo sapiens	0-9
11524145-2	2001	In heterologous expression systems, PKC-mediated modulation is subunit specific with NR2A-containing receptors being potentiated by phorbol 12-myristate 13-acetate (PMA), while NR2C-containing receptors are inhibited or unaffected.	Tetradecanoylphorbol Acetate	132-163	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	85-89
11524145-2	2001	In heterologous expression systems, PKC-mediated modulation is subunit specific with NR2A-containing receptors being potentiated by phorbol 12-myristate 13-acetate (PMA), while NR2C-containing receptors are inhibited or unaffected.	Tetradecanoylphorbol Acetate	165-168	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	85-89
11500310-6	2001	In addition, internalization of the wild-type receptor and the DSEL mutant is stimulated by the PTH analog [Gly(1),Arg(19)]hPTH-(1-28), which does not stimulate phospholipase C. Forskolin, IBMX, and the active phorbol ester, phorbol-12-myristate-13-acetate, did not promote receptor internalization or increase PTH-induced internalization.	Tetradecanoylphorbol Acetate	225-256	dermatan sulfate epimerase like	Homo sapiens	63-67
11500310-6	2001	In addition, internalization of the wild-type receptor and the DSEL mutant is stimulated by the PTH analog [Gly(1),Arg(19)]hPTH-(1-28), which does not stimulate phospholipase C. Forskolin, IBMX, and the active phorbol ester, phorbol-12-myristate-13-acetate, did not promote receptor internalization or increase PTH-induced internalization.	Tetradecanoylphorbol Acetate	225-256	parathyroid hormone	Homo sapiens	96-99
11669302-9	2001	PKC alpha was the only isoform that translocated to the membrane upon stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	114-117	protein kinase C alpha	Homo sapiens	0-9
11532878-0	2001	Role of PKC and MAP kinase in EGF- and TPA-induced connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells.	Tetradecanoylphorbol Acetate	39-42	gap junction protein, alpha 1	Rattus norvegicus	51-61
11532878-4	2001	The induced inhibition of communication by TPA and EGF in IAR6.1 cells is associated with hyperphosphorylation of connexin43, the connexin responsible for GJIC.	Tetradecanoylphorbol Acetate	43-46	gap junction protein, alpha 1	Rattus norvegicus	114-124
11532878-8	2001	Connexin43 hyperphosphorylation induced by TPA is, as for EGF, mediated through MAP kinase, while PKC seems to block GJIC either through other substrates or induces a type of connexin43 phosphorylation that causes no significant electrophoresis mobility shift.	Tetradecanoylphorbol Acetate	43-46	gap junction protein, alpha 1	Rattus norvegicus	0-10
11532880-10	2001	Induction of COX-2 expression by phorbol 12-myristate 13-acetate in HCEC cells increased PGE(2) production 20-fold and MDA concentration 3-fold.	Tetradecanoylphorbol Acetate	33-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18
11527809-7	2001	Percentages of gammadelta+ T cells expressing tumor necrosis factor alpha or gamma interferon in response to phorbol myristate acetate were assayed in vitro.	Tetradecanoylphorbol Acetate	109-134	tumor necrosis factor	Homo sapiens	46-73
11558838-2	2001	Tenecteplase (TNK-tPA) is a novel thrombolytic agent engineered to improve upon the ease of use and safety of alteplase (t-PA).	Tetradecanoylphorbol Acetate	18-21	plasminogen activator, tissue type	Homo sapiens	121-125
11785657-6	2001	A PKC activator, phorbol 12-myristate 13-acetate (PMA), inhibited insulin-dependent Akt phosphorylation.	Tetradecanoylphorbol Acetate	17-48	AKT serine/threonine kinase 1	Rattus norvegicus	84-87
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	Tetradecanoylphorbol Acetate	135-166	C-X-C motif chemokine ligand 8	Homo sapiens	55-68
11785657-6	2001	A PKC activator, phorbol 12-myristate 13-acetate (PMA), inhibited insulin-dependent Akt phosphorylation.	Tetradecanoylphorbol Acetate	50-53	AKT serine/threonine kinase 1	Rattus norvegicus	84-87
11785657-8	2001	We further showed that the PKC inhibitor, G06983, blocked the PMA-induced inhibition of Akt phosphorylation by insulin.	Tetradecanoylphorbol Acetate	62-65	AKT serine/threonine kinase 1	Rattus norvegicus	88-91
11785657-9	2001	In addition, we demonstrated that PMA inhibited the insulin-induced tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1).	Tetradecanoylphorbol Acetate	34-37	insulin receptor substrate 1	Rattus norvegicus	126-131
11516798-8	2001	During the time course of COX-2 mRNA expression in response to treatment with TPA, the COX-2 mRNA band was detected after 1.5h.	Tetradecanoylphorbol Acetate	78-81	prostaglandin-endoperoxide synthase 2	Homo sapiens	26-31
11516798-8	2001	During the time course of COX-2 mRNA expression in response to treatment with TPA, the COX-2 mRNA band was detected after 1.5h.	Tetradecanoylphorbol Acetate	78-81	prostaglandin-endoperoxide synthase 2	Homo sapiens	87-92
11516798-10	2001	After pre-treatment with TPA for 1h, the TPA-induced COX-2 mRNA was suppressed by treatment with DEX for 1 or 2h incubation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	25-28	prostaglandin-endoperoxide synthase 2	Homo sapiens	53-58
11516798-10	2001	After pre-treatment with TPA for 1h, the TPA-induced COX-2 mRNA was suppressed by treatment with DEX for 1 or 2h incubation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	41-44	prostaglandin-endoperoxide synthase 2	Homo sapiens	53-58
11516798-11	2001	CONCLUSIONS: These results suggest that COX-2 mRNA is induced by TPA which activate protein kinase C, and suppressed by DEX in WISH cells.	Tetradecanoylphorbol Acetate	65-68	prostaglandin-endoperoxide synthase 2	Homo sapiens	40-45
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	Tetradecanoylphorbol Acetate	135-166	GLI family zinc finger 2	Homo sapiens	114-119
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	Tetradecanoylphorbol Acetate	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
11477572-12	2001	Both PKC transgenic and wild-type mice exhibited sustained hyperplasia after repeated TPA treatments.	Tetradecanoylphorbol Acetate	86-89	protein kinase C, alpha	Mus musculus	5-8
11477572-14	2001	TPA-induced ODC activity and the resultant accumulation of polyamines may play different roles (e.g., induction of apoptosis vs. proliferation) in the pathways leading to the induction of cancer in PKC alpha, PKC delta and PKC epsilon transgenic mice.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Mus musculus	198-207
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	Tetradecanoylphorbol Acetate	135-166	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
11530010-6	2001	TPA and calcium chelating agents (BAPTA-AM and EGTA) blocked Pyk2 phosphorylation and HB-EGF gene expression.	Tetradecanoylphorbol Acetate	0-3	protein tyrosine kinase 2 beta	Rattus norvegicus	61-65
11509543-10	2001	Downregulation of PKC with phorbol myristate acetate (5 micromol/l) markedly reduced LDL-induced ERK phosphorylation.	Tetradecanoylphorbol Acetate	27-52	Eph receptor B1	Rattus norvegicus	97-100
11530010-6	2001	TPA and calcium chelating agents (BAPTA-AM and EGTA) blocked Pyk2 phosphorylation and HB-EGF gene expression.	Tetradecanoylphorbol Acetate	0-3	heparin-binding EGF-like growth factor	Rattus norvegicus	86-92
11423533-9	2001	Finally, both transient transfection analysis and gel mobility shift assay revealed that the AhRR gene is up-regulated by a p65/p50 heterodimer that binds to the NF-kappaB site when the cells has been exposed to 12-O-tetradecanoylphorbol-13-acetate, and this inducible expression was further enhanced by cotreatment of 12-O-tetradecanoylphorbol-13-acetate and 3-methylcholanthrene.	Tetradecanoylphorbol Acetate	212-248	nuclear factor kappa B subunit 1	Homo sapiens	128-131
11532081-19	2001	Phorbol ester (PMA) treatment stimulated a twofold increase in p38 MAPK activity.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 14	Homo sapiens	63-66
11532081-19	2001	Phorbol ester (PMA) treatment stimulated a twofold increase in p38 MAPK activity.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 1	Homo sapiens	67-71
11529688-6	2001	Topical administration of LDP-392, in a dose-dependent manner, inhibited TPA-induced ear edema in mice and UVB-induced erythema in guinea-pigs.	Tetradecanoylphorbol Acetate	73-76	carboxypeptidase Q	Homo sapiens	26-29
11532083-9	2001	In BS/GS, PKC stimulation with PMA dose dependently reduced ecNOS gene expression (from 0.80 +/- 0.05 to 0.78 +/- 0.03 densitometric units; PMA 50 nmol/L, P = NS; to 0.55 +/- 0.07, PMA 100 nmol/L, P &lt; 0.001) to an undetectable expression (PMA 200 nmol/L).	Tetradecanoylphorbol Acetate	31-34	protein kinase C alpha	Homo sapiens	10-13
11532083-9	2001	In BS/GS, PKC stimulation with PMA dose dependently reduced ecNOS gene expression (from 0.80 +/- 0.05 to 0.78 +/- 0.03 densitometric units; PMA 50 nmol/L, P = NS; to 0.55 +/- 0.07, PMA 100 nmol/L, P &lt; 0.001) to an undetectable expression (PMA 200 nmol/L).	Tetradecanoylphorbol Acetate	31-34	nitric oxide synthase 3	Homo sapiens	60-65
11532083-9	2001	In BS/GS, PKC stimulation with PMA dose dependently reduced ecNOS gene expression (from 0.80 +/- 0.05 to 0.78 +/- 0.03 densitometric units; PMA 50 nmol/L, P = NS; to 0.55 +/- 0.07, PMA 100 nmol/L, P &lt; 0.001) to an undetectable expression (PMA 200 nmol/L).	Tetradecanoylphorbol Acetate	140-143	protein kinase C alpha	Homo sapiens	10-13
11532083-9	2001	In BS/GS, PKC stimulation with PMA dose dependently reduced ecNOS gene expression (from 0.80 +/- 0.05 to 0.78 +/- 0.03 densitometric units; PMA 50 nmol/L, P = NS; to 0.55 +/- 0.07, PMA 100 nmol/L, P &lt; 0.001) to an undetectable expression (PMA 200 nmol/L).	Tetradecanoylphorbol Acetate	140-143	nitric oxide synthase 3	Homo sapiens	60-65
11532083-9	2001	In BS/GS, PKC stimulation with PMA dose dependently reduced ecNOS gene expression (from 0.80 +/- 0.05 to 0.78 +/- 0.03 densitometric units; PMA 50 nmol/L, P = NS; to 0.55 +/- 0.07, PMA 100 nmol/L, P &lt; 0.001) to an undetectable expression (PMA 200 nmol/L).	Tetradecanoylphorbol Acetate	140-143	protein kinase C alpha	Homo sapiens	10-13
11532083-9	2001	In BS/GS, PKC stimulation with PMA dose dependently reduced ecNOS gene expression (from 0.80 +/- 0.05 to 0.78 +/- 0.03 densitometric units; PMA 50 nmol/L, P = NS; to 0.55 +/- 0.07, PMA 100 nmol/L, P &lt; 0.001) to an undetectable expression (PMA 200 nmol/L).	Tetradecanoylphorbol Acetate	140-143	nitric oxide synthase 3	Homo sapiens	60-65
11532088-5	2001	The effect of LMW heparin on the binding of nuclear proteins to a regulatory activator protein-1 (AP-1) site, which mediates the high glucose and PMA responsiveness of the TGF-beta 1 promoter, was studied by electrophoretic mobility shift assays.	Tetradecanoylphorbol Acetate	146-149	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-96
11532088-5	2001	The effect of LMW heparin on the binding of nuclear proteins to a regulatory activator protein-1 (AP-1) site, which mediates the high glucose and PMA responsiveness of the TGF-beta 1 promoter, was studied by electrophoretic mobility shift assays.	Tetradecanoylphorbol Acetate	146-149	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-102
11532088-5	2001	The effect of LMW heparin on the binding of nuclear proteins to a regulatory activator protein-1 (AP-1) site, which mediates the high glucose and PMA responsiveness of the TGF-beta 1 promoter, was studied by electrophoretic mobility shift assays.	Tetradecanoylphorbol Acetate	146-149	transforming growth factor beta 1	Homo sapiens	172-182
11532088-6	2001	RESULTS: The presence of LMW heparin completely prevented TGF-beta 1 gene activation in both high glucose- and PMA-stimulated cells.	Tetradecanoylphorbol Acetate	111-114	transforming growth factor beta 1	Homo sapiens	58-68
11522330-1	2001	To assess a possible role for phospholipase D (PLD) in PC12 cell signal transduction and differentiation, we have investigated the expression of PLD in PC12 cells and found that the differentiation factor, nerve growth factor (NGF) increased PLD1 protein expression and phorbol 12-myristate 13 acetate (PMA)-induced PLD activity.	Tetradecanoylphorbol Acetate	270-301	phospholipase D1	Rattus norvegicus	242-246
11522330-1	2001	To assess a possible role for phospholipase D (PLD) in PC12 cell signal transduction and differentiation, we have investigated the expression of PLD in PC12 cells and found that the differentiation factor, nerve growth factor (NGF) increased PLD1 protein expression and phorbol 12-myristate 13 acetate (PMA)-induced PLD activity.	Tetradecanoylphorbol Acetate	303-306	phospholipase D1	Rattus norvegicus	242-246
11680625-7	2001	Pretreatment of intact acini with a phorbol ester (4beta-phorbol 12-myristate 13-acetate, PMA) to activate PLD1 protein kinase C (PKC) dependently did not change the subcellular distribution of PLD1.	Tetradecanoylphorbol Acetate	51-88	phospholipase D1	Rattus norvegicus	107-111
11680625-7	2001	Pretreatment of intact acini with a phorbol ester (4beta-phorbol 12-myristate 13-acetate, PMA) to activate PLD1 protein kinase C (PKC) dependently did not change the subcellular distribution of PLD1.	Tetradecanoylphorbol Acetate	90-93	phospholipase D1	Rattus norvegicus	107-111
11520498-1	2001	Previous studies from this laboratory have demonstrated that fibroblast growth factor 1 together with a number of co-activator molecules (dopamine, TPA, IBMX/forskolin), will induce the expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in 10% of human neurons (hNTs) derived from the NT2 cell line [10].	Tetradecanoylphorbol Acetate	148-151	fibroblast growth factor 1	Homo sapiens	61-87
11520498-1	2001	Previous studies from this laboratory have demonstrated that fibroblast growth factor 1 together with a number of co-activator molecules (dopamine, TPA, IBMX/forskolin), will induce the expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in 10% of human neurons (hNTs) derived from the NT2 cell line [10].	Tetradecanoylphorbol Acetate	148-151	tyrosine hydroxylase	Homo sapiens	238-258
11520498-1	2001	Previous studies from this laboratory have demonstrated that fibroblast growth factor 1 together with a number of co-activator molecules (dopamine, TPA, IBMX/forskolin), will induce the expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in 10% of human neurons (hNTs) derived from the NT2 cell line [10].	Tetradecanoylphorbol Acetate	148-151	tyrosine hydroxylase	Homo sapiens	260-262
11423533-9	2001	Finally, both transient transfection analysis and gel mobility shift assay revealed that the AhRR gene is up-regulated by a p65/p50 heterodimer that binds to the NF-kappaB site when the cells has been exposed to 12-O-tetradecanoylphorbol-13-acetate, and this inducible expression was further enhanced by cotreatment of 12-O-tetradecanoylphorbol-13-acetate and 3-methylcholanthrene.	Tetradecanoylphorbol Acetate	319-355	nuclear factor kappa B subunit 1	Homo sapiens	128-131
11413129-5	2001	Pre-incubation with selective protein kinase C (PKC) inhibitors GF109203X and Go6983, or transfection of dominant negative (DN)-PKC alpha, abolished phorbol 12-myristate 13-acetate-mediated c-Jun N-terminal kinase activity, although it only partially inhibited the response to trypsin.	Tetradecanoylphorbol Acetate	149-180	protein kinase C alpha	Homo sapiens	48-51
11517301-5	2001	Stable expression of dnIkkbeta also blocked phorbol 12-myristate 13-acetate (PMA)-induced activation of NF-kappaB and overexpression of cyclin D1, concomitantly with the loss or reduced tumorigenic potential of these cells.	Tetradecanoylphorbol Acetate	44-75	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	104-113
11517301-5	2001	Stable expression of dnIkkbeta also blocked phorbol 12-myristate 13-acetate (PMA)-induced activation of NF-kappaB and overexpression of cyclin D1, concomitantly with the loss or reduced tumorigenic potential of these cells.	Tetradecanoylphorbol Acetate	77-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	104-113
11413129-5	2001	Pre-incubation with selective protein kinase C (PKC) inhibitors GF109203X and Go6983, or transfection of dominant negative (DN)-PKC alpha, abolished phorbol 12-myristate 13-acetate-mediated c-Jun N-terminal kinase activity, although it only partially inhibited the response to trypsin.	Tetradecanoylphorbol Acetate	149-180	protein kinase C alpha	Homo sapiens	128-137
11514592-2	2001	Interestingly, PPARalpha and beta expression is reactivated in the adult epidermis after various stimuli, resulting in keratinocyte proliferation and differentiation such as tetradecanoylphorbol acetate topical application, hair plucking, or skin wound healing.	Tetradecanoylphorbol Acetate	174-202	peroxisome proliferator activated receptor alpha	Mus musculus	15-24
11507084-2	2001	Bay 11-7085 had no effect on the basal levels of phosphorylated IkappaBalpha but completely inhibited phorbol 12-myristate 13-acetate-induced phosphorylation of IkappaBalpha.	Tetradecanoylphorbol Acetate	102-133	NFKB inhibitor alpha	Homo sapiens	161-173
11485559-8	2001	Consistent with PLD1 up-regulation was the observation that PLD enzymic activity was higher in monocytes treated with active-pathogen-derived agonists than in control cells, when stimulated with PMA or with chemotactic agonists (fMet-Leu-Phe and C5a).	Tetradecanoylphorbol Acetate	195-198	phospholipase D1	Homo sapiens	16-20
11507057-8	2001	Overexpression of MnSOD selectively inhibited the TPA-induced activation of protein kinase Cepsilon and prevented subsequent activation of c-Jun NH(2)-terminal kinase in response to TPA.	Tetradecanoylphorbol Acetate	50-53	superoxide dismutase 2, mitochondrial	Mus musculus	18-23
11507057-8	2001	Overexpression of MnSOD selectively inhibited the TPA-induced activation of protein kinase Cepsilon and prevented subsequent activation of c-Jun NH(2)-terminal kinase in response to TPA.	Tetradecanoylphorbol Acetate	182-185	superoxide dismutase 2, mitochondrial	Mus musculus	18-23
11485567-4	2001	Here we provide evidence that PMA-induced IL-6Ralpha shedding is controlled by a metalloproteinase and by protein kinase C (PKC) isoenzymes that do not require Ca(2+) for their activation.	Tetradecanoylphorbol Acetate	30-33	interleukin 6 receptor	Homo sapiens	42-52
11485567-8	2001	In addition, by using rottlerin, a specific inhibitor of PKC-delta, we demonstrate that PKC-delta is involved in the PMA-induced shedding of IL-6Ralpha.	Tetradecanoylphorbol Acetate	117-120	interleukin 6 receptor	Homo sapiens	141-151
11485567-9	2001	With the use of UO126, a specific inhibitor of the mitogen-activated protein kinase (MAPK) pathway, we show that the PMA-induced IL-6Ralpha shedding is mediated in part by the MAPK pathway.	Tetradecanoylphorbol Acetate	117-120	mitogen-activated protein kinase 3	Homo sapiens	85-89
11485567-9	2001	With the use of UO126, a specific inhibitor of the mitogen-activated protein kinase (MAPK) pathway, we show that the PMA-induced IL-6Ralpha shedding is mediated in part by the MAPK pathway.	Tetradecanoylphorbol Acetate	117-120	interleukin 6 receptor	Homo sapiens	129-139
11485567-9	2001	With the use of UO126, a specific inhibitor of the mitogen-activated protein kinase (MAPK) pathway, we show that the PMA-induced IL-6Ralpha shedding is mediated in part by the MAPK pathway.	Tetradecanoylphorbol Acetate	117-120	mitogen-activated protein kinase 3	Homo sapiens	176-180
11485567-11	2001	Taken together, these results suggest that the PMA-induced shedding of IL-6Ralpha is mediated by a PKC isoenzyme network.	Tetradecanoylphorbol Acetate	47-50	interleukin 6 receptor	Homo sapiens	71-81
11507084-3	2001	Although Bay 11-7085 prevented phorbol 12-myristate 13-acetate-induced NF-kappaB nuclear translocation, SN50, a specific inhibitor of nuclear translocation and function of NF-kappaB, did not induce any significant nuclear/DNA fragmentation, caspase 3 activation, or cell death.	Tetradecanoylphorbol Acetate	31-62	nuclear factor kappa B subunit 1	Homo sapiens	71-80
11478838-4	2001	Following TPA treatment: lamins A/C and B1, B2 and vimentin increased in amount; LAP2 beta and emerin remained essentially unchanged; LBR increased markedly; histone subtypes H1.4 and 1.5 exhibited dephosphorylation.	Tetradecanoylphorbol Acetate	10-13	lamin B receptor	Homo sapiens	134-137
11526476-9	2001	Also, PMA (phorbol 12-myristate 13-acetate)-stimulated NF-kappaB activation is suppressed by menin.	Tetradecanoylphorbol Acetate	6-9	menin 1	Homo sapiens	93-98
11526476-9	2001	Also, PMA (phorbol 12-myristate 13-acetate)-stimulated NF-kappaB activation is suppressed by menin.	Tetradecanoylphorbol Acetate	11-42	menin 1	Homo sapiens	93-98
11443050-3	2001	In neutrophilic HL60 cells, the PKC activator phorbol myristate acetate (PMA) activates multiple PKC isotypes, PKC-alpha, PKC-beta, and PKC-delta, and inhibits ligand-initiated mobilization of intracellular Ca(2+) and uptake of extracellular Ca(2+).	Tetradecanoylphorbol Acetate	46-71	protein kinase C alpha	Homo sapiens	32-35
11489969-7	2001	Stimulatory activity of TPA on HCMV replication was suppressed by protein kinase C inhibitors and inhibitors of p42/44 and p38 mitogen-activated protein kinases but not by NF-kappaB inhibitors.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 14	Homo sapiens	123-126
11443064-4	2001	By subcellular fractionation and Western blot, PMA (100 nM) induced sequential membrane translocation of the novel PKC epsilon followed by the conventional PKC alpha and activated both isozymes by in vitro kinase assay.	Tetradecanoylphorbol Acetate	47-50	protein kinase C alpha	Homo sapiens	156-165
11443064-7	2001	Inhibition of I(sc) by PMA was prevented by the conventional and novel PKC inhibitor Go-6850 (5 microM) but not the conventional isoform inhibitor Go-6976 (5 microM) or the PKC delta inhibitor rottlerin (10 microM), implicating PKC epsilon in inhibition of Cl(-) secretion.	Tetradecanoylphorbol Acetate	23-26	protein kinase C alpha	Homo sapiens	71-74
11489969-6	2001	Cyclooxygenase-2 expression and PGE2 release was increased by TPA and TNF-alpha but not by HCMV infection.	Tetradecanoylphorbol Acetate	62-65	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
11478764-4	2001	All reagents which induce the activation of ERKs induce Sprouty gene expression; these agents include not only growth factors which bind to RTK but also phorbol 12-myristate-13-acetate and active Raf-1 kinase.	Tetradecanoylphorbol Acetate	153-184	mitogen-activated protein kinase 1	Homo sapiens	44-48
11478764-4	2001	All reagents which induce the activation of ERKs induce Sprouty gene expression; these agents include not only growth factors which bind to RTK but also phorbol 12-myristate-13-acetate and active Raf-1 kinase.	Tetradecanoylphorbol Acetate	153-184	sprouty	Drosophila melanogaster	56-63
11478766-5	2001	Comparing different c-mpl-transfected cell lines, we found that the amount of histamine generated in response to TPO correlated with their responsiveness to PMA, but not with their level of c-mpl expression, thus revealing an intrinsic basophil differentiation potential.	Tetradecanoylphorbol Acetate	157-160	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	20-25
11478766-5	2001	Comparing different c-mpl-transfected cell lines, we found that the amount of histamine generated in response to TPO correlated with their responsiveness to PMA, but not with their level of c-mpl expression, thus revealing an intrinsic basophil differentiation potential.	Tetradecanoylphorbol Acetate	157-160	thrombopoietin	Homo sapiens	113-116
11443053-1	2001	Expression of endothelial nitric oxide synthase (eNOS) in transfected U-937 cells upregulates phorbol 12-myristate 13-acetate (PMA)-induced tumor necrosis factor-alpha (TNF-alpha) production through a superoxide (O(2)(-))-dependent mechanism.	Tetradecanoylphorbol Acetate	94-125	tumor necrosis factor	Homo sapiens	169-178
11443053-1	2001	Expression of endothelial nitric oxide synthase (eNOS) in transfected U-937 cells upregulates phorbol 12-myristate 13-acetate (PMA)-induced tumor necrosis factor-alpha (TNF-alpha) production through a superoxide (O(2)(-))-dependent mechanism.	Tetradecanoylphorbol Acetate	127-130	nitric oxide synthase 3	Homo sapiens	14-47
11443053-1	2001	Expression of endothelial nitric oxide synthase (eNOS) in transfected U-937 cells upregulates phorbol 12-myristate 13-acetate (PMA)-induced tumor necrosis factor-alpha (TNF-alpha) production through a superoxide (O(2)(-))-dependent mechanism.	Tetradecanoylphorbol Acetate	127-130	nitric oxide synthase 3	Homo sapiens	49-53
11443053-1	2001	Expression of endothelial nitric oxide synthase (eNOS) in transfected U-937 cells upregulates phorbol 12-myristate 13-acetate (PMA)-induced tumor necrosis factor-alpha (TNF-alpha) production through a superoxide (O(2)(-))-dependent mechanism.	Tetradecanoylphorbol Acetate	127-130	tumor necrosis factor	Homo sapiens	140-167
11443053-1	2001	Expression of endothelial nitric oxide synthase (eNOS) in transfected U-937 cells upregulates phorbol 12-myristate 13-acetate (PMA)-induced tumor necrosis factor-alpha (TNF-alpha) production through a superoxide (O(2)(-))-dependent mechanism.	Tetradecanoylphorbol Acetate	127-130	tumor necrosis factor	Homo sapiens	169-178
11443050-3	2001	In neutrophilic HL60 cells, the PKC activator phorbol myristate acetate (PMA) activates multiple PKC isotypes, PKC-alpha, PKC-beta, and PKC-delta, and inhibits ligand-initiated mobilization of intracellular Ca(2+) and uptake of extracellular Ca(2+).	Tetradecanoylphorbol Acetate	46-71	protein kinase C alpha	Homo sapiens	97-100
11443050-3	2001	In neutrophilic HL60 cells, the PKC activator phorbol myristate acetate (PMA) activates multiple PKC isotypes, PKC-alpha, PKC-beta, and PKC-delta, and inhibits ligand-initiated mobilization of intracellular Ca(2+) and uptake of extracellular Ca(2+).	Tetradecanoylphorbol Acetate	46-71	protein kinase C alpha	Homo sapiens	111-120
11443050-3	2001	In neutrophilic HL60 cells, the PKC activator phorbol myristate acetate (PMA) activates multiple PKC isotypes, PKC-alpha, PKC-beta, and PKC-delta, and inhibits ligand-initiated mobilization of intracellular Ca(2+) and uptake of extracellular Ca(2+).	Tetradecanoylphorbol Acetate	73-76	protein kinase C alpha	Homo sapiens	32-35
11443050-3	2001	In neutrophilic HL60 cells, the PKC activator phorbol myristate acetate (PMA) activates multiple PKC isotypes, PKC-alpha, PKC-beta, and PKC-delta, and inhibits ligand-initiated mobilization of intracellular Ca(2+) and uptake of extracellular Ca(2+).	Tetradecanoylphorbol Acetate	73-76	protein kinase C alpha	Homo sapiens	97-100
11443050-3	2001	In neutrophilic HL60 cells, the PKC activator phorbol myristate acetate (PMA) activates multiple PKC isotypes, PKC-alpha, PKC-beta, and PKC-delta, and inhibits ligand-initiated mobilization of intracellular Ca(2+) and uptake of extracellular Ca(2+).	Tetradecanoylphorbol Acetate	73-76	protein kinase C alpha	Homo sapiens	111-120
11443053-1	2001	Expression of endothelial nitric oxide synthase (eNOS) in transfected U-937 cells upregulates phorbol 12-myristate 13-acetate (PMA)-induced tumor necrosis factor-alpha (TNF-alpha) production through a superoxide (O(2)(-))-dependent mechanism.	Tetradecanoylphorbol Acetate	94-125	nitric oxide synthase 3	Homo sapiens	14-47
11485906-8	2001	Stimulation with phorbol 12-myristate 13-acetate (PMA) reduced L-selectin andincreased CD18 expression.	Tetradecanoylphorbol Acetate	17-48	selectin, lymphocyte	Mus musculus	63-73
11443053-1	2001	Expression of endothelial nitric oxide synthase (eNOS) in transfected U-937 cells upregulates phorbol 12-myristate 13-acetate (PMA)-induced tumor necrosis factor-alpha (TNF-alpha) production through a superoxide (O(2)(-))-dependent mechanism.	Tetradecanoylphorbol Acetate	94-125	nitric oxide synthase 3	Homo sapiens	49-53
11485906-8	2001	Stimulation with phorbol 12-myristate 13-acetate (PMA) reduced L-selectin andincreased CD18 expression.	Tetradecanoylphorbol Acetate	17-48	integrin beta 2	Mus musculus	87-91
11485906-8	2001	Stimulation with phorbol 12-myristate 13-acetate (PMA) reduced L-selectin andincreased CD18 expression.	Tetradecanoylphorbol Acetate	50-53	selectin, lymphocyte	Mus musculus	63-73
11443053-1	2001	Expression of endothelial nitric oxide synthase (eNOS) in transfected U-937 cells upregulates phorbol 12-myristate 13-acetate (PMA)-induced tumor necrosis factor-alpha (TNF-alpha) production through a superoxide (O(2)(-))-dependent mechanism.	Tetradecanoylphorbol Acetate	94-125	tumor necrosis factor	Homo sapiens	140-167
11485906-8	2001	Stimulation with phorbol 12-myristate 13-acetate (PMA) reduced L-selectin andincreased CD18 expression.	Tetradecanoylphorbol Acetate	50-53	integrin beta 2	Mus musculus	87-91
11505407-10	2001	CONCLUSIONS: The current results provide the first insights into the regulation of EpCAM expression, which is regulated negatively by TNFalpha and TPA through the activation of NF-kappaB.	Tetradecanoylphorbol Acetate	147-150	epithelial cell adhesion molecule	Homo sapiens	83-88
11483407-7	2001	12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC activator, stimulated ICAM-1 expression, this effect was inhibited by genistein or tyrphostin 23.	Tetradecanoylphorbol Acetate	0-36	protein kinase C alpha	Homo sapiens	46-49
11483407-7	2001	12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC activator, stimulated ICAM-1 expression, this effect was inhibited by genistein or tyrphostin 23.	Tetradecanoylphorbol Acetate	38-41	protein kinase C alpha	Homo sapiens	46-49
11483407-13	2001	TNF-alpha- or TPA-induced ICAM-1 promoter activity was inhibited by dominant negative PKCalpha or IKK2, but not IKK1 mutant.	Tetradecanoylphorbol Acetate	14-17	protein kinase C alpha	Homo sapiens	86-94
11483411-2	2001	In this study, we investigated the effect of the phorbol 12-myristate 13-acetate (PMA) on the expression of VEGF in human bladder transitional carcinoma cells (RT4).	Tetradecanoylphorbol Acetate	49-80	vascular endothelial growth factor A	Homo sapiens	108-112
11483411-2	2001	In this study, we investigated the effect of the phorbol 12-myristate 13-acetate (PMA) on the expression of VEGF in human bladder transitional carcinoma cells (RT4).	Tetradecanoylphorbol Acetate	82-85	vascular endothelial growth factor A	Homo sapiens	108-112
11526432-1	2001	Treatment of human U-937 myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with activation of the stress-activated protein kinase (SAPK) and induction of terminal monocytic differentiation.	Tetradecanoylphorbol Acetate	53-89	mitogen-activated protein kinase 9	Homo sapiens	133-164
11526432-1	2001	Treatment of human U-937 myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with activation of the stress-activated protein kinase (SAPK) and induction of terminal monocytic differentiation.	Tetradecanoylphorbol Acetate	53-89	mitogen-activated protein kinase 9	Homo sapiens	166-170
11526432-1	2001	Treatment of human U-937 myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with activation of the stress-activated protein kinase (SAPK) and induction of terminal monocytic differentiation.	Tetradecanoylphorbol Acetate	91-94	mitogen-activated protein kinase 9	Homo sapiens	133-164
11526432-1	2001	Treatment of human U-937 myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with activation of the stress-activated protein kinase (SAPK) and induction of terminal monocytic differentiation.	Tetradecanoylphorbol Acetate	91-94	mitogen-activated protein kinase 9	Homo sapiens	166-170
11526432-5	2001	Overexpression of Bcl-x(L) attenuated the apoptotic response to TPA treatment.	Tetradecanoylphorbol Acetate	64-67	BCL2 like 1	Homo sapiens	18-26
11505407-10	2001	CONCLUSIONS: The current results provide the first insights into the regulation of EpCAM expression, which is regulated negatively by TNFalpha and TPA through the activation of NF-kappaB.	Tetradecanoylphorbol Acetate	147-150	nuclear factor kappa B subunit 1	Homo sapiens	177-186
11526432-2	2001	The present studies demonstrate that TPA targets SAPK to mitochondria by a mechanism dependent on activation of protein kinase C (PKC) beta.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 9	Homo sapiens	49-53
11526432-3	2001	Translocation of SAPK to mitochondria in response to TPA is associated with release of cytochrome c, caspase-3 activation and induction of apoptosis.	Tetradecanoylphorbol Acetate	53-56	mitogen-activated protein kinase 9	Homo sapiens	17-21
11529914-2	2001	We have studied the regulation of CD154 expression in human T cells after activation with anti-CD3 and anti-CD28 antibodies or after pharmacological activation of protein kinase C with phorbol 12-myristate 13-acetate, and the calcium ionophore ionomycin.	Tetradecanoylphorbol Acetate	185-216	CD40 ligand	Homo sapiens	34-39
11526432-3	2001	Translocation of SAPK to mitochondria in response to TPA is associated with release of cytochrome c, caspase-3 activation and induction of apoptosis.	Tetradecanoylphorbol Acetate	53-56	cytochrome c, somatic	Homo sapiens	87-99
11526432-3	2001	Translocation of SAPK to mitochondria in response to TPA is associated with release of cytochrome c, caspase-3 activation and induction of apoptosis.	Tetradecanoylphorbol Acetate	53-56	caspase 3	Homo sapiens	101-110
11526432-4	2001	The results show that TPA induces the association of SAPK with the mitochondrial anti-apoptotic Bcl-x(L) protein.	Tetradecanoylphorbol Acetate	22-25	mitogen-activated protein kinase 9	Homo sapiens	53-57
11526432-4	2001	The results show that TPA induces the association of SAPK with the mitochondrial anti-apoptotic Bcl-x(L) protein.	Tetradecanoylphorbol Acetate	22-25	BCL2 like 1	Homo sapiens	96-104
11526432-6	2001	Moreover, expression of Bcl-x(L) mutated at sites of SAPK phosphorylation (Thr-47, -115) was more effective than wild-type Bcl-x(L) in abrogating TPA-induced cytochrome c release and apoptosis.	Tetradecanoylphorbol Acetate	146-149	BCL2 like 1	Homo sapiens	24-32
11526432-6	2001	Moreover, expression of Bcl-x(L) mutated at sites of SAPK phosphorylation (Thr-47, -115) was more effective than wild-type Bcl-x(L) in abrogating TPA-induced cytochrome c release and apoptosis.	Tetradecanoylphorbol Acetate	146-149	mitogen-activated protein kinase 9	Homo sapiens	53-57
11526432-6	2001	Moreover, expression of Bcl-x(L) mutated at sites of SAPK phosphorylation (Thr-47, -115) was more effective than wild-type Bcl-x(L) in abrogating TPA-induced cytochrome c release and apoptosis.	Tetradecanoylphorbol Acetate	146-149	BCL2 like 1	Homo sapiens	24-29
11526432-6	2001	Moreover, expression of Bcl-x(L) mutated at sites of SAPK phosphorylation (Thr-47, -115) was more effective than wild-type Bcl-x(L) in abrogating TPA-induced cytochrome c release and apoptosis.	Tetradecanoylphorbol Acetate	146-149	cytochrome c, somatic	Homo sapiens	158-170
11526432-8	2001	These findings indicate that myeloid leukemia cells respond to TPA with targeting of SAPK to mitochondria and that this response contributes to terminal differentiation through the release of cytochrome c and induction of apoptosis.	Tetradecanoylphorbol Acetate	63-66	mitogen-activated protein kinase 9	Homo sapiens	85-89
11526432-8	2001	These findings indicate that myeloid leukemia cells respond to TPA with targeting of SAPK to mitochondria and that this response contributes to terminal differentiation through the release of cytochrome c and induction of apoptosis.	Tetradecanoylphorbol Acetate	63-66	cytochrome c, somatic	Homo sapiens	192-204
11529915-3	2001	On the other hand, phorbol esters such as PMA induce primary human CD34+ bone marrow (BM) progenitor cells to differentiate into functional DC and no other lineages are generated.	Tetradecanoylphorbol Acetate	42-45	CD34 molecule	Homo sapiens	67-71
11459804-7	2001	IL-6 production was only slightly increased by either 8-bromo-cAMP (1 mM) or phorbol 12-myristate 13-acetate (100 nM) alone.	Tetradecanoylphorbol Acetate	77-108	interleukin 6	Mus musculus	0-4
11459804-8	2001	However, IL-6 was synergistically induced in the presence of both 8-bromo-cAMP (1 mM) and phorbol 12myristate 13-acetate (100 nM).	Tetradecanoylphorbol Acetate	90-120	interleukin 6	Mus musculus	9-13
11446769-5	2001	Protein kinase C (PKC) activator TPA also induced the phosphorylation of p70 S6K.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	0-16
11446769-5	2001	Protein kinase C (PKC) activator TPA also induced the phosphorylation of p70 S6K.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	18-21
11461775-8	2001	Further, the vitamin was able to amplify the PMA-dependent induction of p38 and pJNK.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase 14	Homo sapiens	72-75
11460267-6	2001	Pretreatment of cells with the protein kinase C (PKC) inhibitor bisindolylmaleimide I, or downregulation of PKC by 24-h treatment with the phorbol ester TPA inhibited carbachol-induced MAPK activation.	Tetradecanoylphorbol Acetate	153-156	protein kinase C alpha	Homo sapiens	108-111
11488907-6	2001	Treatment of these cells with ponasterone A induced expression of PKC that was catalytically active and underwent translocation and down-regulation on exposure to 12-O-tetradecanoyl-13-phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	202-205	protein kinase C alpha	Homo sapiens	66-69
11488907-8	2001	In PKC-alpha expressing cells TPA caused activation of all promoter fragments to -29 bp.	Tetradecanoylphorbol Acetate	30-33	protein kinase C alpha	Homo sapiens	3-12
11488907-9	2001	This finding suggests that TPA-inducible MDR1 transcription mediated through the TPA responsive factor early growth response 1 (EGR-1) in this region of the promoter may be due to activation of PKC-alpha.	Tetradecanoylphorbol Acetate	27-30	ATP binding cassette subfamily B member 1	Homo sapiens	41-45
11488907-9	2001	This finding suggests that TPA-inducible MDR1 transcription mediated through the TPA responsive factor early growth response 1 (EGR-1) in this region of the promoter may be due to activation of PKC-alpha.	Tetradecanoylphorbol Acetate	27-30	protein kinase C alpha	Homo sapiens	194-203
11488907-9	2001	This finding suggests that TPA-inducible MDR1 transcription mediated through the TPA responsive factor early growth response 1 (EGR-1) in this region of the promoter may be due to activation of PKC-alpha.	Tetradecanoylphorbol Acetate	81-84	ATP binding cassette subfamily B member 1	Homo sapiens	41-45
11488907-9	2001	This finding suggests that TPA-inducible MDR1 transcription mediated through the TPA responsive factor early growth response 1 (EGR-1) in this region of the promoter may be due to activation of PKC-alpha.	Tetradecanoylphorbol Acetate	81-84	protein kinase C alpha	Homo sapiens	194-203
11488907-11	2001	The effect of TPA on reporter gene expression was attenuated by the PKC inhibitor GF 109203X.	Tetradecanoylphorbol Acetate	14-17	protein kinase C alpha	Homo sapiens	68-71
11424083-8	2001	The PLC inhibitors, neomycin and U73,122, and PKC-alpha down regulator, phorbol 12-myristate 13-acetate (PMA), were able to prevent estradiol-induced DNA synthesis in hepatoma cells, but ineffective in mammary cells; wortmannin, an inhibitor of phosphoinositide 3-kinases (PI3-K), blocked DNA synthesis in both cell lines.	Tetradecanoylphorbol Acetate	72-103	protein kinase C alpha	Homo sapiens	46-55
11476900-4	2001	Here we report that DP cells that were treated with PMA and ionomycin up-regulated bcl-2 and down-regulated CD1 expression.	Tetradecanoylphorbol Acetate	52-55	BCL2 apoptosis regulator	Homo sapiens	83-88
11424083-8	2001	The PLC inhibitors, neomycin and U73,122, and PKC-alpha down regulator, phorbol 12-myristate 13-acetate (PMA), were able to prevent estradiol-induced DNA synthesis in hepatoma cells, but ineffective in mammary cells; wortmannin, an inhibitor of phosphoinositide 3-kinases (PI3-K), blocked DNA synthesis in both cell lines.	Tetradecanoylphorbol Acetate	105-108	protein kinase C alpha	Homo sapiens	46-55
11511407-3	2001	RESULTS: Using the nuclear transcription factor CREB as a target, both the activation of the cyclic AMP-PKA pathway by isoproterenol and the activation of the PKC pathway by PMA caused phosphorylation of nuclear CREB.	Tetradecanoylphorbol Acetate	174-177	proline rich transmembrane protein 2	Homo sapiens	159-162
11573238-6	2001	Co-treatment with phorbol myristate acetate decreased vasopressin-dependent Ca(2+) mobilization and slowed appearance of new GRP78 molecules in response to the hormone, whereas 24 h pretreatment with phorbol ester prolonged vasopressin-dependent Ca(2+) mobilization and further increased rates of GRP78 synthesis in response to the hormone.	Tetradecanoylphorbol Acetate	18-43	arginine vasopressin	Homo sapiens	54-65
11573238-6	2001	Co-treatment with phorbol myristate acetate decreased vasopressin-dependent Ca(2+) mobilization and slowed appearance of new GRP78 molecules in response to the hormone, whereas 24 h pretreatment with phorbol ester prolonged vasopressin-dependent Ca(2+) mobilization and further increased rates of GRP78 synthesis in response to the hormone.	Tetradecanoylphorbol Acetate	18-43	heat shock protein family A (Hsp70) member 5	Homo sapiens	297-302
11573238-6	2001	Co-treatment with phorbol myristate acetate decreased vasopressin-dependent Ca(2+) mobilization and slowed appearance of new GRP78 molecules in response to the hormone, whereas 24 h pretreatment with phorbol ester prolonged vasopressin-dependent Ca(2+) mobilization and further increased rates of GRP78 synthesis in response to the hormone.	Tetradecanoylphorbol Acetate	18-43	heat shock protein family A (Hsp70) member 5	Homo sapiens	125-130
11467851-4	2001	Phorbol 12-myristate, 13-acetate (PMA)-stimulated APP secretion, which was reduced by a general PKC inhibitor bisindoylmaleimide I, but not by Go 6976, which inhibits PKCalpha, beta, gamma, and mu.	Tetradecanoylphorbol Acetate	34-37	protein kinase C alpha	Homo sapiens	96-99
11493622-6	2001	LPS, zymosan, and PMA caused marked and dose-dependent increases in TNF-alpha and IL-10 production.	Tetradecanoylphorbol Acetate	18-21	tumor necrosis factor	Homo sapiens	68-77
11493622-7	2001	Addition of OX-RBC augmented the LPS-, zymosan-, and PMA-induced TNF-alpha release by approximately 100%.	Tetradecanoylphorbol Acetate	53-56	tumor necrosis factor	Homo sapiens	65-74
11592732-7	2001	Furthermore, we observed that DHA significantly inhibited PMA-induced translocation of two PKC isoforms, PKC alpha and PKC epsilon, from cytosol to plasma membrane.	Tetradecanoylphorbol Acetate	58-61	protein kinase C, alpha	Mus musculus	91-94
11592732-7	2001	Furthermore, we observed that DHA significantly inhibited PMA-induced translocation of two PKC isoforms, PKC alpha and PKC epsilon, from cytosol to plasma membrane.	Tetradecanoylphorbol Acetate	58-61	protein kinase C, alpha	Mus musculus	105-114
11483662-6	2001	The effect of lead on DNA synthesis was mediated through PKC as evidenced by the finding that two PKC inhibitors, GF 109203X and staurosporine, as well as down-regulation of PKC through prolonged treatment with 12-O-tetradecanoylphorbol 13-acetate, blocked lead-induced DNA synthesis.	Tetradecanoylphorbol Acetate	211-247	proline rich transmembrane protein 2	Homo sapiens	57-60
11466413-3	2001	The formation of PICK1-PKCalpha complexes is strongly induced by TPA, and PICK1-PKCalpha complexes are cotargeted with PICK1-GluR2 complexes to spines, where GluR2 is found to be phosphorylated by PKC on serine 880.	Tetradecanoylphorbol Acetate	65-68	protein kinase C alpha	Homo sapiens	23-31
11466413-3	2001	The formation of PICK1-PKCalpha complexes is strongly induced by TPA, and PICK1-PKCalpha complexes are cotargeted with PICK1-GluR2 complexes to spines, where GluR2 is found to be phosphorylated by PKC on serine 880.	Tetradecanoylphorbol Acetate	65-68	protein kinase C alpha	Homo sapiens	23-26
11408087-6	2001	The results showed that both melatonin and the PKC agonist phorbol-12-myristate-13-acetate increased PKC activity in isolated IFs.	Tetradecanoylphorbol Acetate	59-90	protein kinase C, alpha	Mus musculus	47-50
11408087-6	2001	The results showed that both melatonin and the PKC agonist phorbol-12-myristate-13-acetate increased PKC activity in isolated IFs.	Tetradecanoylphorbol Acetate	59-90	protein kinase C, alpha	Mus musculus	101-104
11408087-10	2001	Phorbol-12-myristate-13-acetate modified the subcellular distribution of both PKC isoforms.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, alpha	Mus musculus	78-81
11467851-4	2001	Phorbol 12-myristate, 13-acetate (PMA)-stimulated APP secretion, which was reduced by a general PKC inhibitor bisindoylmaleimide I, but not by Go 6976, which inhibits PKCalpha, beta, gamma, and mu.	Tetradecanoylphorbol Acetate	34-37	protein kinase C alpha	Homo sapiens	167-175
11444823-0	2001	Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells.	Tetradecanoylphorbol Acetate	81-84	cyclin dependent kinase inhibitor 2B	Homo sapiens	15-25
11587480-0	2001	Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	181-217	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	33-39
11587480-0	2001	Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	181-217	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	90-96
11587480-1	2001	PURPOSE: To examine the changes in expression levels of CYP3A4 and efflux transporters in CYP3A4-transfected Caco-2 (colon carcinoma) cells in the presence of the inducers sodium butyrate (NaB) and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	198-234	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	56-62
11587480-1	2001	PURPOSE: To examine the changes in expression levels of CYP3A4 and efflux transporters in CYP3A4-transfected Caco-2 (colon carcinoma) cells in the presence of the inducers sodium butyrate (NaB) and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	198-234	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	90-96
11587480-1	2001	PURPOSE: To examine the changes in expression levels of CYP3A4 and efflux transporters in CYP3A4-transfected Caco-2 (colon carcinoma) cells in the presence of the inducers sodium butyrate (NaB) and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	236-239	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	56-62
11587480-1	2001	PURPOSE: To examine the changes in expression levels of CYP3A4 and efflux transporters in CYP3A4-transfected Caco-2 (colon carcinoma) cells in the presence of the inducers sodium butyrate (NaB) and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	236-239	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	90-96
11587480-9	2001	CONCLUSIONS: The present study characterized CYP3A4-Caco-2 cell monolayers when induced for 24 h in the presence of both NaB and TPA.	Tetradecanoylphorbol Acetate	129-132	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	45-51
11448162-0	2001	12-O-tetradecanoylphorbol-13-acetate induces Epstein-Barr virus reactivation via NF-kappaB and AP-1 as regulated by protein kinase C and mitogen-activated protein kinase.	Tetradecanoylphorbol Acetate	0-36	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	95-99
11448162-2	2001	The consequences of protein kinase C (PKC) activation by TPA in inhibiting inducible nitric oxide synthase (iNOS) mRNA expression were analyzed in the EBV-infected gastric epithelial cell line GT38.	Tetradecanoylphorbol Acetate	57-60	nitric oxide synthase 2	Homo sapiens	108-112
11448162-4	2001	In such cells the PKC inhibitors 1-(5-isoquinolinesulphonyl)-2,5-dimethylpiperazine (H7) and staurosporine inhibited TPA-induced expression of BZLF1 and BRLF1 and reversed TPA-mediated inhibition of iNOS gene expression.	Tetradecanoylphorbol Acetate	117-120	nitric oxide synthase 2	Homo sapiens	199-203
11448162-6	2001	Electrophoretic mobility shift assays demonstrated that transcription factors NF-kappaB and AP-1 were also activated by TPA in a time-dependent manner.	Tetradecanoylphorbol Acetate	120-123	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	92-96
11448162-10	2001	These results show that TPA induces EBV reactivation via NF-kappaB and AP-1 and that PKC is an important mediator in regulating gene expression leading to EBV reactivation after TPA treatment of GT38 cells.	Tetradecanoylphorbol Acetate	24-27	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-75
11352899-4	2001	The PKC activator, phorbol 12-myristate 13-acetate (PMA), promoted a Ca(2+) influx that was significantly attenuated by calphostin C and La(3+) but not by diltiazem.	Tetradecanoylphorbol Acetate	19-50	proline rich transmembrane protein 2	Homo sapiens	4-7
11352899-4	2001	The PKC activator, phorbol 12-myristate 13-acetate (PMA), promoted a Ca(2+) influx that was significantly attenuated by calphostin C and La(3+) but not by diltiazem.	Tetradecanoylphorbol Acetate	52-55	proline rich transmembrane protein 2	Homo sapiens	4-7
11444823-5	2001	On the other hand, the phorbol ester tumor promoter TPA (12-O-Tetredecanolyphorbol 13-acetate) also inhibited HepG2 growth and specifically induced p-16(INK4a) and p-15(INK4b) mRNA expression.	Tetradecanoylphorbol Acetate	52-55	cyclin dependent kinase inhibitor 2A	Homo sapiens	148-152
11444823-5	2001	On the other hand, the phorbol ester tumor promoter TPA (12-O-Tetredecanolyphorbol 13-acetate) also inhibited HepG2 growth and specifically induced p-16(INK4a) and p-15(INK4b) mRNA expression.	Tetradecanoylphorbol Acetate	52-55	cyclin dependent kinase inhibitor 2A	Homo sapiens	153-158
11444823-5	2001	On the other hand, the phorbol ester tumor promoter TPA (12-O-Tetredecanolyphorbol 13-acetate) also inhibited HepG2 growth and specifically induced p-16(INK4a) and p-15(INK4b) mRNA expression.	Tetradecanoylphorbol Acetate	52-55	cyclin dependent kinase inhibitor 2B	Homo sapiens	164-168
11444823-0	2001	Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells.	Tetradecanoylphorbol Acetate	81-84	cyclin dependent kinase inhibitor 2A	Homo sapiens	36-41
11457458-3	2001	Raf-annexin 6 interaction was shown to be independent of cell activation by epidermal growth factor (EGF) or phorbol esters (12-O-tetradecanoyl-phorbol-13-acetate (TPA)).	Tetradecanoylphorbol Acetate	125-162	annexin A6	Rattus norvegicus	4-13
11444823-5	2001	On the other hand, the phorbol ester tumor promoter TPA (12-O-Tetredecanolyphorbol 13-acetate) also inhibited HepG2 growth and specifically induced p-16(INK4a) and p-15(INK4b) mRNA expression.	Tetradecanoylphorbol Acetate	52-55	cyclin dependent kinase inhibitor 2B	Homo sapiens	169-174
11342553-3	2001	Serum, lysophosphatidic acid, platelet-derived growth factor, and phorbol 12-myristate 13-acetate (PMA) each activated transcription of a stably integrated SRF reporter gene dependent on functional RhoA GTPase.	Tetradecanoylphorbol Acetate	66-97	ras homolog family member A	Homo sapiens	198-202
11444823-6	2001	The results suggest that both saikosaponin a and TPA-induced HepG2 growth inhibition are associated with p-15(INK4a) and p-16(INK4b) gene expression and might be mediated by PKC signaling pathway.	Tetradecanoylphorbol Acetate	49-52	cyclin dependent kinase inhibitor 2B	Homo sapiens	105-109
11444823-6	2001	The results suggest that both saikosaponin a and TPA-induced HepG2 growth inhibition are associated with p-15(INK4a) and p-16(INK4b) gene expression and might be mediated by PKC signaling pathway.	Tetradecanoylphorbol Acetate	49-52	cyclin dependent kinase inhibitor 2A	Homo sapiens	110-115
11444823-6	2001	The results suggest that both saikosaponin a and TPA-induced HepG2 growth inhibition are associated with p-15(INK4a) and p-16(INK4b) gene expression and might be mediated by PKC signaling pathway.	Tetradecanoylphorbol Acetate	49-52	cyclin dependent kinase inhibitor 2B	Homo sapiens	121-131
11585388-7	2001	Exposure of preactivated T cells to IL-2 also inhibited subsequent responses to the mitogenic combination of PMA, ionomycin, and IL-2 without enhancing cell death.	Tetradecanoylphorbol Acetate	109-112	interleukin 2	Homo sapiens	36-40
11457458-3	2001	Raf-annexin 6 interaction was shown to be independent of cell activation by epidermal growth factor (EGF) or phorbol esters (12-O-tetradecanoyl-phorbol-13-acetate (TPA)).	Tetradecanoylphorbol Acetate	164-167	annexin A6	Rattus norvegicus	4-13
11309389-8	2001	The GH concentration dependence for inhibition of PMA-induced GHR proteolysis paralleled that for its promotion of receptor dimerization (as monitored by formation of GHR disulfide linkage).	Tetradecanoylphorbol Acetate	50-53	somatotropin	Oryctolagus cuniculus	4-6
11309389-10	2001	Our data suggest that GH inhibits PMA-induced GHR proteolysis and GHBP shedding by inducing GHR dimerization and that this effect does not appear to be related to GH site 1 binding, GHR internalization, or GHR signaling.	Tetradecanoylphorbol Acetate	34-37	somatotropin	Oryctolagus cuniculus	22-24
11309389-10	2001	Our data suggest that GH inhibits PMA-induced GHR proteolysis and GHBP shedding by inducing GHR dimerization and that this effect does not appear to be related to GH site 1 binding, GHR internalization, or GHR signaling.	Tetradecanoylphorbol Acetate	34-37	somatotropin	Oryctolagus cuniculus	46-48
11342553-3	2001	Serum, lysophosphatidic acid, platelet-derived growth factor, and phorbol 12-myristate 13-acetate (PMA) each activated transcription of a stably integrated SRF reporter gene dependent on functional RhoA GTPase.	Tetradecanoylphorbol Acetate	99-102	ras homolog family member A	Homo sapiens	198-202
11749832-3	2001	The effects of triptolide on VEGF mRNA expression, production, and secretion induced by 12-o-tetradecanoyl-phorbol-13-acetate (TPA) were measured by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR), flow cytometry, and enzyme linked immunosorbent assay (ELISA) respectively.	Tetradecanoylphorbol Acetate	88-125	vascular endothelial growth factor A	Homo sapiens	29-33
11547951-2	2001	In this study we investigated the effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) on differentiation and on PKC isozymes of human skeletal muscle satellite cells.	Tetradecanoylphorbol Acetate	63-94	protein kinase C alpha	Homo sapiens	49-52
11547951-2	2001	In this study we investigated the effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) on differentiation and on PKC isozymes of human skeletal muscle satellite cells.	Tetradecanoylphorbol Acetate	96-99	protein kinase C alpha	Homo sapiens	49-52
11547951-7	2001	Our findings, therefore, suggest that the PMA-induced inhibition of differentiation of human skeletal muscle cells is mediated by certain PKC isoforms.	Tetradecanoylphorbol Acetate	42-45	protein kinase C alpha	Homo sapiens	138-141
11435917-7	2001	A PKC activator, TPA, mimicked orexin-A in increasing [Ca2+]i.	Tetradecanoylphorbol Acetate	17-20	hypocretin neuropeptide precursor	Rattus norvegicus	31-39
11421927-8	2001	In contrast, the expression of VLA-4 and Mac-1 was decreased after the incubation with PMA for 24 h. The PMA-induced upregulation of ICAM-1 was inhibited by dexamethasone in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	87-90	integrin subunit beta 2	Homo sapiens	41-46
11421927-8	2001	In contrast, the expression of VLA-4 and Mac-1 was decreased after the incubation with PMA for 24 h. The PMA-induced upregulation of ICAM-1 was inhibited by dexamethasone in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	105-108	integrin subunit beta 2	Homo sapiens	41-46
11749832-3	2001	The effects of triptolide on VEGF mRNA expression, production, and secretion induced by 12-o-tetradecanoyl-phorbol-13-acetate (TPA) were measured by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR), flow cytometry, and enzyme linked immunosorbent assay (ELISA) respectively.	Tetradecanoylphorbol Acetate	127-130	vascular endothelial growth factor A	Homo sapiens	29-33
11749832-5	2001	RESULTS: VEGF mRNA expression was markedly up-regulated by TPA-stimulation.	Tetradecanoylphorbol Acetate	59-62	vascular endothelial growth factor A	Homo sapiens	9-13
11749832-6	2001	In addition, the production and secretion of VEGF in endothelial cells also increased in TPA treated cells.	Tetradecanoylphorbol Acetate	89-92	vascular endothelial growth factor A	Homo sapiens	45-49
11749832-7	2001	It was founded that triptolide inhibited VEGF mRNA expression, protein production and secretion in endothelial cells induced by TPA.	Tetradecanoylphorbol Acetate	128-131	vascular endothelial growth factor A	Homo sapiens	41-45
11428860-2	2001	These studies were designed to evaluate the role extracellular signal-regulated kinase (ERK) pathway plays in mediating the responses to platelet-derived growth factor-BB (PDGF-BB) and phorbol 12-myristate 13-acetate (PMA) in trabecular meshwork cells.	Tetradecanoylphorbol Acetate	185-216	mitogen-activated protein kinase 1	Homo sapiens	49-86
11724286-5	2001	We found that both sulindac sulfide and TPA caused growth inhibition, cell cycle arrest in G0/G1 and increased levels of the cell cycle inhibitory proteins p21Cip1 and p27KiP1.	Tetradecanoylphorbol Acetate	40-43	cyclin dependent kinase inhibitor 1A	Homo sapiens	156-163
11472441-6	2001	In contrast, the serine protease inhibitor N-methoxysuccinyl-alanine-alanine-proline-valine-chloromethylketone (MeOsuc-AAPV-CMK) largely blocked cyto B + fMLP-induced, but not PMA-induced shedding of Fc gamma RIIIb.	Tetradecanoylphorbol Acetate	176-179	C-X-C motif chemokine ligand 9	Homo sapiens	124-127
11404058-4	2001	Interferon-gamma, phorbol myristate acetate and interleukin-6 all stimulated C9 mRNA expression but the inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, as well as the anaphylatoxin C5a and the bacterial lipopolysaccharide, were ineffective.	Tetradecanoylphorbol Acetate	18-43	interleukin 1 beta	Homo sapiens	156-174
11428860-2	2001	These studies were designed to evaluate the role extracellular signal-regulated kinase (ERK) pathway plays in mediating the responses to platelet-derived growth factor-BB (PDGF-BB) and phorbol 12-myristate 13-acetate (PMA) in trabecular meshwork cells.	Tetradecanoylphorbol Acetate	185-216	mitogen-activated protein kinase 1	Homo sapiens	88-91
11428860-2	2001	These studies were designed to evaluate the role extracellular signal-regulated kinase (ERK) pathway plays in mediating the responses to platelet-derived growth factor-BB (PDGF-BB) and phorbol 12-myristate 13-acetate (PMA) in trabecular meshwork cells.	Tetradecanoylphorbol Acetate	218-221	mitogen-activated protein kinase 1	Homo sapiens	49-86
11428860-2	2001	These studies were designed to evaluate the role extracellular signal-regulated kinase (ERK) pathway plays in mediating the responses to platelet-derived growth factor-BB (PDGF-BB) and phorbol 12-myristate 13-acetate (PMA) in trabecular meshwork cells.	Tetradecanoylphorbol Acetate	218-221	mitogen-activated protein kinase 1	Homo sapiens	88-91
11428860-6	2001	The addition of PDGF-BB or PMA produced time- and dose-dependent activation of ERK 1/2.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 3	Homo sapiens	79-86
11506744-1	2001	Treatment of T cells with phorbol esters, such as phorbol myristate acetate (PMA), induces downregulation of CD4, making unambiguous identification of this subset difficult.	Tetradecanoylphorbol Acetate	50-75	CD4 molecule	Homo sapiens	109-112
11433229-10	2001	The stimulatory effects of AGE-BSA on collagen gene regulation in HMCs could be negated by the pretreatment of HMCs with GF 109203X for 30 minutes or with phorbol myristate acetate for 24 hours before AGE-BSA administration.	Tetradecanoylphorbol Acetate	155-180	MKKS centrosomal shuttling protein	Homo sapiens	66-70
11690563-6	2001	12-O-tetradecanoylphorbol-13-acetate, which stimulates ERK activity in U937 cells, markedly reduced lectin-II-induced DNA fragmentation.	Tetradecanoylphorbol Acetate	0-36	mitogen-activated protein kinase 3	Homo sapiens	55-58
11443195-9	2001	The change in PKC isoform in PKC-depleted cells (achieved by exposure to PMA for 18 h) was also examined.	Tetradecanoylphorbol Acetate	73-76	protein kinase C alpha	Homo sapiens	14-17
11384667-4	2001	Phorbol 12-myristate 13-acetate (PMA) engenders megakaryocytic differentiation in K-562 cell populations, as measured by presentation of the beta(3) integrin (gpIIIa, CD61), while maintaining a negative expression of MHC-I and MHC-II molecules.	Tetradecanoylphorbol Acetate	0-31	integrin subunit beta 3	Homo sapiens	159-165
11384667-4	2001	Phorbol 12-myristate 13-acetate (PMA) engenders megakaryocytic differentiation in K-562 cell populations, as measured by presentation of the beta(3) integrin (gpIIIa, CD61), while maintaining a negative expression of MHC-I and MHC-II molecules.	Tetradecanoylphorbol Acetate	0-31	integrin subunit beta 3	Homo sapiens	167-171
11384667-4	2001	Phorbol 12-myristate 13-acetate (PMA) engenders megakaryocytic differentiation in K-562 cell populations, as measured by presentation of the beta(3) integrin (gpIIIa, CD61), while maintaining a negative expression of MHC-I and MHC-II molecules.	Tetradecanoylphorbol Acetate	33-36	integrin subunit beta 3	Homo sapiens	159-165
11384667-4	2001	Phorbol 12-myristate 13-acetate (PMA) engenders megakaryocytic differentiation in K-562 cell populations, as measured by presentation of the beta(3) integrin (gpIIIa, CD61), while maintaining a negative expression of MHC-I and MHC-II molecules.	Tetradecanoylphorbol Acetate	33-36	integrin subunit beta 3	Homo sapiens	167-171
11506744-1	2001	Treatment of T cells with phorbol esters, such as phorbol myristate acetate (PMA), induces downregulation of CD4, making unambiguous identification of this subset difficult.	Tetradecanoylphorbol Acetate	77-80	CD4 molecule	Homo sapiens	109-112
11436183-9	2001	Stimulation of hyaluronan production by PMA was also normalized by anti TGFbeta neutralizing antibody, but the effect of TGF-beta1 was not affected by inhibition of PKC.	Tetradecanoylphorbol Acetate	40-43	transforming growth factor, beta 1	Rattus norvegicus	72-79
11461971-5	2001	The phorbol ester TPA produced an increase in ERK phosphorylation that was blocked by the PKC inhibitors GF109203X or Go6976.	Tetradecanoylphorbol Acetate	18-21	mitogen-activated protein kinase 1	Homo sapiens	46-49
11461971-6	2001	TPA-dependent ERK phosphorylation was also blocked by the MEK1 inhibitors PD098059 or U0126.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	14-17
11313339-3	2001	We demonstrate that in human choriocarcinoma BeWo cells, the PKC activator 12-O-tetradecanoyl phorbol 13-acetate and PKC inhibitor bisindolylmaleimide reciprocally down- and up-regulate, respectively, TEF-mediated GGAATG core enhancer activity.	Tetradecanoylphorbol Acetate	75-112	TEF transcription factor, PAR bZIP family member	Homo sapiens	201-204
11408599-9	2001	PACAP and TPA both increased the binding activity of the SgII cAMP response element to trans-acting factors present in chromaffin cell nuclear extracts, which are recognized by antibodies to activator protein-1-related proteins.	Tetradecanoylphorbol Acetate	10-13	secretogranin II	Bos taurus	57-61
11389019-3	2001	Treatment of intact platelets with thrombin or the stable thromboxane A(2) analog STA(2) resulted in increased phosphorylation of both CPI and MBS at Thr-696, whereas phorbol myristate acetate (PMA) and the Ca(++) ionophore ionomycin only induced CPI phosphorylation.	Tetradecanoylphorbol Acetate	167-192	coagulation factor II, thrombin	Homo sapiens	35-43
11309397-3	2001	Thrombin and phorbol 12-myristate 13-acetate induced rapid phosphorylation of GDI and the activation of Rho-A in human umbilical venular endothelial cells.	Tetradecanoylphorbol Acetate	13-44	ras homolog family member A	Homo sapiens	104-109
11304541-4	2001	In addition, TPA treatment led to the appearance of full-length IRF-2, along with a reduction of the truncated protein.	Tetradecanoylphorbol Acetate	13-16	interferon regulatory factor 2	Homo sapiens	64-69
11304541-5	2001	Interestingly, full-length IRF-2 in TPA-treated U937 cells occurred as a complex with p300 as well as PCAF and was itself acetylated.	Tetradecanoylphorbol Acetate	36-39	interferon regulatory factor 2	Homo sapiens	27-32
11304541-9	2001	The addition of IRF-2 also inhibited acetylation of nucleosomal histones in TPA-treated U937 cells.	Tetradecanoylphorbol Acetate	76-79	interferon regulatory factor 2	Homo sapiens	16-21
11500965-0	2001	Inhibition of connexin43 gap junctional intercellular communication by TPA requires ERK activation.	Tetradecanoylphorbol Acetate	71-74	gap junction protein, alpha 1	Rattus norvegicus	14-24
11500965-0	2001	Inhibition of connexin43 gap junctional intercellular communication by TPA requires ERK activation.	Tetradecanoylphorbol Acetate	71-74	Eph receptor B1	Rattus norvegicus	84-87
11500965-4	2001	TPA treatment (10 ng/ml for 30 min) of WB-F344 rat liver epithelial cells strongly activated p42 and p44 ERK-1 and -2, blocked gap junction-mediated fluorescent dye-coupling, and induced connexin43 hyperphosphorylation and gap junction internalization.	Tetradecanoylphorbol Acetate	0-3	gap junction protein, alpha 1	Rattus norvegicus	187-197
11389037-4	2001	By using cell-free systems, it was demonstrated that the mitochondrial pathway to cell death that involves mitochondrial membrane depolarization, cytochrome c release and cytosolic activation of procaspases by cytochrome c/dATP remains functional in TPA-differentiated U937 cells.	Tetradecanoylphorbol Acetate	250-253	cytochrome c, somatic	Homo sapiens	146-158
11389037-4	2001	By using cell-free systems, it was demonstrated that the mitochondrial pathway to cell death that involves mitochondrial membrane depolarization, cytochrome c release and cytosolic activation of procaspases by cytochrome c/dATP remains functional in TPA-differentiated U937 cells.	Tetradecanoylphorbol Acetate	250-253	cytochrome c, somatic	Homo sapiens	210-222
11390183-7	2001	Similar to alpha-tocopherol, the protein kinase C inhibitor, Calphostin C, and the MAPK inhibitor, PD98059, prevented PMA-induced cell adhesion.	Tetradecanoylphorbol Acetate	118-121	mitogen-activated protein kinase 3	Homo sapiens	83-87
11389019-3	2001	Treatment of intact platelets with thrombin or the stable thromboxane A(2) analog STA(2) resulted in increased phosphorylation of both CPI and MBS at Thr-696, whereas phorbol myristate acetate (PMA) and the Ca(++) ionophore ionomycin only induced CPI phosphorylation.	Tetradecanoylphorbol Acetate	194-197	coagulation factor II, thrombin	Homo sapiens	35-43
11389019-6	2001	The PKC inhibitor, GF109203X, inhibited PMA-induced phosphorylation of CPI and MLC(20) with similar IC(50) values.	Tetradecanoylphorbol Acetate	40-43	proline rich transmembrane protein 2	Homo sapiens	4-7
11389019-6	2001	The PKC inhibitor, GF109203X, inhibited PMA-induced phosphorylation of CPI and MLC(20) with similar IC(50) values.	Tetradecanoylphorbol Acetate	40-43	myosin light chain 12B	Homo sapiens	79-86
11480589-5	2001	VEGF mRNA expression and protein secretion were found to be enhanced by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	72-103	vascular endothelial growth factor A	Homo sapiens	0-4
11352830-5	2001	In vitro experiments using isolated leukocytes treated with phorbol 12-myristate 13-acetate showed that monocytes and neutrophils but not lymphocytes were hyperreactive to cell activation, as measured by CD11b overexpression and increased L-selectin shedding in PPVL rats.	Tetradecanoylphorbol Acetate	60-91	integrin subunit alpha M	Rattus norvegicus	204-209
11892999-9	2001	Furthermore, we have shown that the IL-6 receptor complex is functional in U-937-1 cells induced to differentiate towards a secretory macrophage by treatment with PMA.	Tetradecanoylphorbol Acetate	163-166	interleukin 6	Homo sapiens	36-40
11412209-2	2001	The proportion of cytokine-producing CD4+ cells was determined by flow cytometric analysis after stimulating the cells with phorbol 12-myristate 13-acetate, ionomycin and brefeldin A, and staining the cells with fluorescein isothiocyanate-labelled anti-interferon-gamma, anti-interleukin-4 and anti-immunoglubulin-2b antibodies.	Tetradecanoylphorbol Acetate	124-155	CD4 molecule	Homo sapiens	37-40
11356718-3	2001	Insulin-induced JNK activation was potentiated by either preincubating cells with 2 nM GF109203X (PKC inhibitor) or down-regulation of PKC by overnight treatment with 100 nM tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	174-203	insulin	Homo sapiens	0-7
11453541-8	2001	Treatment with PMA (phorbol 12-myristate 13-acetate), a PKC activator, suppressed Trail-induced apoptosis in Jurkat T cells.	Tetradecanoylphorbol Acetate	15-18	TNF superfamily member 10	Homo sapiens	82-87
11453541-8	2001	Treatment with PMA (phorbol 12-myristate 13-acetate), a PKC activator, suppressed Trail-induced apoptosis in Jurkat T cells.	Tetradecanoylphorbol Acetate	20-51	TNF superfamily member 10	Homo sapiens	82-87
11378866-1	2001	BACKGROUND: Identification of human T-helper cell subsets is possible by measurement of intracellular cytokines after coincubation of lymphocytes with phorbol myristate acetate (PMA), calcium ionophore, and brefeldin A for up to 20 h. However, exposure to PMA leads to internalization of membrane CD4 and to loss of resolution of the CD4+ cells.	Tetradecanoylphorbol Acetate	151-176	CD4 molecule	Homo sapiens	297-300
11378866-1	2001	BACKGROUND: Identification of human T-helper cell subsets is possible by measurement of intracellular cytokines after coincubation of lymphocytes with phorbol myristate acetate (PMA), calcium ionophore, and brefeldin A for up to 20 h. However, exposure to PMA leads to internalization of membrane CD4 and to loss of resolution of the CD4+ cells.	Tetradecanoylphorbol Acetate	151-176	CD4 molecule	Homo sapiens	334-337
11356718-3	2001	Insulin-induced JNK activation was potentiated by either preincubating cells with 2 nM GF109203X (PKC inhibitor) or down-regulation of PKC by overnight treatment with 100 nM tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	174-203	mitogen-activated protein kinase 8	Homo sapiens	16-19
11356718-4	2001	In contrast, brief preincubation with 100 nM tetradecanoyl phorbol acetate inhibited the insulin- induced JNK activation.	Tetradecanoylphorbol Acetate	45-74	insulin	Homo sapiens	89-96
11356718-4	2001	In contrast, brief preincubation with 100 nM tetradecanoyl phorbol acetate inhibited the insulin- induced JNK activation.	Tetradecanoylphorbol Acetate	45-74	mitogen-activated protein kinase 8	Homo sapiens	106-109
11523909-8	2001	PMA (phorbol 12-myristate 13-acetate) dose-dependently reversed the PCO-400-induced suppression of insulin-stimulated glucose uptake.	Tetradecanoylphorbol Acetate	0-3	insulin	Homo sapiens	99-106
11523909-8	2001	PMA (phorbol 12-myristate 13-acetate) dose-dependently reversed the PCO-400-induced suppression of insulin-stimulated glucose uptake.	Tetradecanoylphorbol Acetate	5-36	insulin	Homo sapiens	99-106
11412302-3	2001	We began by analysing cytokine production by human CD4+ CD45RA- memory/effector T cells following brief (4 hr) stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	128-159	CD4 molecule	Homo sapiens	51-54
11368509-1	2001	The levels of Pim-1, a serine/threonine kinase, increase during phorbol myristate acetate (PMA)-induced myeloid cell differentiation.	Tetradecanoylphorbol Acetate	64-89	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	14-19
11368509-1	2001	The levels of Pim-1, a serine/threonine kinase, increase during phorbol myristate acetate (PMA)-induced myeloid cell differentiation.	Tetradecanoylphorbol Acetate	91-94	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	14-19
11400863-3	2001	Three different types of agents; epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate (TPA), and fetal bovine serum (FBS) induced different patterns of ERK activation.	Tetradecanoylphorbol Acetate	64-100	mitogen-activated protein kinase 1	Homo sapiens	167-170
11400863-3	2001	Three different types of agents; epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate (TPA), and fetal bovine serum (FBS) induced different patterns of ERK activation.	Tetradecanoylphorbol Acetate	102-105	mitogen-activated protein kinase 1	Homo sapiens	167-170
11400863-6	2001	Activation by EGF and TPA and the early response induced by FBS were strongly reduced by the MEK inhibitor PD98059.	Tetradecanoylphorbol Acetate	22-25	mitogen-activated protein kinase kinase 7	Homo sapiens	93-96
11359792-6	2001	HNE inhibits TPA/IM-induced degradation of IkappaBalpha in both H1299 and Jurkat T cells.	Tetradecanoylphorbol Acetate	13-16	NFKB inhibitor alpha	Homo sapiens	43-55
11409113-5	2001	CD154 expression was analyzed on PB or SF CD4+ T cells after double staining (CD4/CD154) by flow cytometry at basal conditions and after different stimuli [anti-CD3 or phorbol myristic acetate (PMA) plus ionomycin].	Tetradecanoylphorbol Acetate	194-197	CD40 ligand	Homo sapiens	0-5
11353829-10	2001	Phorbol 12-myristate 13-acetate, which strongly activates ERK1/2, also inhibited TNF-alpha activation of JNK.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 3	Homo sapiens	58-64
11353829-10	2001	Phorbol 12-myristate 13-acetate, which strongly activates ERK1/2, also inhibited TNF-alpha activation of JNK.	Tetradecanoylphorbol Acetate	0-31	tumor necrosis factor	Homo sapiens	81-90
11353829-10	2001	Phorbol 12-myristate 13-acetate, which strongly activates ERK1/2, also inhibited TNF-alpha activation of JNK.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 8	Homo sapiens	105-108
11278846-2	2001	This study demonstrates that sodium salicylate at a therapeutic concentration suppressed COX-2 gene transcription induced by phorbol 12-myristate 13-acetate and interleukin 1beta by inhibiting the binding of CCAAT/enhancer-binding protein beta to its promoter region of COX-2.	Tetradecanoylphorbol Acetate	125-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
11278846-2	2001	This study demonstrates that sodium salicylate at a therapeutic concentration suppressed COX-2 gene transcription induced by phorbol 12-myristate 13-acetate and interleukin 1beta by inhibiting the binding of CCAAT/enhancer-binding protein beta to its promoter region of COX-2.	Tetradecanoylphorbol Acetate	125-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	270-275
11392472-4	2001	N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated neutrophil adhesion was inhibited by wortmannin and LY294002, two unrelated PI-3K inhibitors, whereas phorbol myristate acetate (PMA)-induced neutrophil adhesion was not inhibited by them.	Tetradecanoylphorbol Acetate	160-185	formyl peptide receptor 1	Homo sapiens	41-45
11392472-4	2001	N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated neutrophil adhesion was inhibited by wortmannin and LY294002, two unrelated PI-3K inhibitors, whereas phorbol myristate acetate (PMA)-induced neutrophil adhesion was not inhibited by them.	Tetradecanoylphorbol Acetate	187-190	formyl peptide receptor 1	Homo sapiens	41-45
11359904-4	2001	Overexpression of a nondegradable IkappaBalpha mutant (IkappaBalpha-SR) or lack of IkappaB kinase gamma expression completely prevented phorbol myristate acetate-induced upregulation of cFLIP mRNA in Jurkat cells.	Tetradecanoylphorbol Acetate	136-161	NFKB inhibitor alpha	Homo sapiens	34-46
11359904-4	2001	Overexpression of a nondegradable IkappaBalpha mutant (IkappaBalpha-SR) or lack of IkappaB kinase gamma expression completely prevented phorbol myristate acetate-induced upregulation of cFLIP mRNA in Jurkat cells.	Tetradecanoylphorbol Acetate	136-161	NFKB inhibitor alpha	Homo sapiens	55-67
11359904-4	2001	Overexpression of a nondegradable IkappaBalpha mutant (IkappaBalpha-SR) or lack of IkappaB kinase gamma expression completely prevented phorbol myristate acetate-induced upregulation of cFLIP mRNA in Jurkat cells.	Tetradecanoylphorbol Acetate	136-161	CASP8 and FADD like apoptosis regulator	Homo sapiens	186-191
11359912-6	2001	In the three clones expressing rPLD1-V5, PLD activity stimulated by phorbol myristate acetate (PMA) or lysophosphatidic acid (LPA) was reduced by ~50%, while the PLD activity of Rat2V20 cells was normal.	Tetradecanoylphorbol Acetate	68-93	phospholipase D1	Rattus norvegicus	31-36
11359912-6	2001	In the three clones expressing rPLD1-V5, PLD activity stimulated by phorbol myristate acetate (PMA) or lysophosphatidic acid (LPA) was reduced by ~50%, while the PLD activity of Rat2V20 cells was normal.	Tetradecanoylphorbol Acetate	95-98	phospholipase D1	Rattus norvegicus	31-36
11434688-5	2001	Ad/t-PA infection of phorbol myristate acetate (PMA)-differentiated MEG-01 cells increased cellular t-PA levels by 120 fold (1580 +/- 130 ng/10(6) cells at 5 MOI) in comparison to non-or Ad/beta-gal-infected cells.	Tetradecanoylphorbol Acetate	21-46	plasminogen activator, tissue type	Homo sapiens	3-7
11434688-5	2001	Ad/t-PA infection of phorbol myristate acetate (PMA)-differentiated MEG-01 cells increased cellular t-PA levels by 120 fold (1580 +/- 130 ng/10(6) cells at 5 MOI) in comparison to non-or Ad/beta-gal-infected cells.	Tetradecanoylphorbol Acetate	21-46	plasminogen activator, tissue type	Homo sapiens	100-104
11434688-5	2001	Ad/t-PA infection of phorbol myristate acetate (PMA)-differentiated MEG-01 cells increased cellular t-PA levels by 120 fold (1580 +/- 130 ng/10(6) cells at 5 MOI) in comparison to non-or Ad/beta-gal-infected cells.	Tetradecanoylphorbol Acetate	48-51	plasminogen activator, tissue type	Homo sapiens	3-7
11434688-5	2001	Ad/t-PA infection of phorbol myristate acetate (PMA)-differentiated MEG-01 cells increased cellular t-PA levels by 120 fold (1580 +/- 130 ng/10(6) cells at 5 MOI) in comparison to non-or Ad/beta-gal-infected cells.	Tetradecanoylphorbol Acetate	48-51	plasminogen activator, tissue type	Homo sapiens	100-104
11359792-4	2001	Pretreatment of cells with HNE dose-dependently suppresses tetradecanoylphorbol acetate (TPA)/ionomycin (IM)-induced NF-kappaB DNA binding activity and transactivation of luciferase-based reporter constructs.	Tetradecanoylphorbol Acetate	59-87	nuclear factor kappa B subunit 1	Homo sapiens	117-126
11359792-4	2001	Pretreatment of cells with HNE dose-dependently suppresses tetradecanoylphorbol acetate (TPA)/ionomycin (IM)-induced NF-kappaB DNA binding activity and transactivation of luciferase-based reporter constructs.	Tetradecanoylphorbol Acetate	89-92	nuclear factor kappa B subunit 1	Homo sapiens	117-126
11311131-5	2001	Furthermore, PMA-induced Hic-5 tyrosine phosphorylation was also observed when platelets adhered to immobilized fibrinogen.	Tetradecanoylphorbol Acetate	13-16	fibrinogen beta chain	Homo sapiens	112-122
11358804-3	2001	We show here that in JNK2-deficient (Jnk2(-/-)) mice, the multiplicity of papillomas induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) was lower than that in wild-type mice.	Tetradecanoylphorbol Acetate	96-132	mitogen-activated protein kinase 9	Mus musculus	37-41
11358804-3	2001	We show here that in JNK2-deficient (Jnk2(-/-)) mice, the multiplicity of papillomas induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) was lower than that in wild-type mice.	Tetradecanoylphorbol Acetate	134-137	mitogen-activated protein kinase 9	Mus musculus	37-41
11358804-5	2001	After the 12th week of TPA treatment, the mean number of tumors per mouse was 4.13-4.86 in wild-type mice but only 1.13-2.5 in Jnk2(-/-) mice.	Tetradecanoylphorbol Acetate	23-26	mitogen-activated protein kinase 9	Mus musculus	127-131
11358804-6	2001	TPA induced phosphorylation of extracellular signal-regulated kinases and activator protein-1 DNA binding activity in wild-type mice, but the phosphorylation of extracellular signal-regulated kinases and activator protein-1 DNA binding were inhibited in Jnk2(-/-) mice.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 9	Mus musculus	254-258
11327693-2	2001	We found that PMA-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) increased its binding with Tob that exerts an anti-proliferative effect through the binding with ErbB-2.	Tetradecanoylphorbol Acetate	14-17	erb-b2 receptor tyrosine kinase 2	Homo sapiens	197-203
11287316-3	2001	Phosphorylation of p92 was inducible when Mac-1 was activated by phorbol 12-myristate 13-acetate, the beta(2)-specific activating antibody CBR LFA-1/2, or interleukin-8 (77 amino acids).	Tetradecanoylphorbol Acetate	65-96	advillin	Homo sapiens	19-22
11446745-2	2001	IL-1beta up-regulation is not dependent on PKC but the PKC activator PMA induces low levels of GM-CSF production and acts synergistically with IL-1beta to further increase GM-CSF.	Tetradecanoylphorbol Acetate	69-72	interleukin 1 beta	Homo sapiens	0-8
11295059-0	2001	Protein kinase C activation by PMA rapidly induces apoptosis through caspase-3/CPP32 and serine protease(s) in a gastric cancer cell line.	Tetradecanoylphorbol Acetate	31-34	caspase 3	Homo sapiens	69-78
11312556-2	2001	The novel expression of TH in these cells is signaled by the synergistic interaction of factors present in the media, such as fibroblast growth factor 1 (FGF1) and one of several possible coactivators [DA, phorbol 12-myristate 13-acetate (TPA), isobutylmethylxanthine (IBMX), or forskolin].	Tetradecanoylphorbol Acetate	206-237	tyrosine hydroxylase	Homo sapiens	24-26
11312556-2	2001	The novel expression of TH in these cells is signaled by the synergistic interaction of factors present in the media, such as fibroblast growth factor 1 (FGF1) and one of several possible coactivators [DA, phorbol 12-myristate 13-acetate (TPA), isobutylmethylxanthine (IBMX), or forskolin].	Tetradecanoylphorbol Acetate	239-242	tyrosine hydroxylase	Homo sapiens	24-26
11312556-2	2001	The novel expression of TH in these cells is signaled by the synergistic interaction of factors present in the media, such as fibroblast growth factor 1 (FGF1) and one of several possible coactivators [DA, phorbol 12-myristate 13-acetate (TPA), isobutylmethylxanthine (IBMX), or forskolin].	Tetradecanoylphorbol Acetate	239-242	fibroblast growth factor 1	Homo sapiens	126-152
11380624-2	2001	In this study, we investigated the roles of Syk and other PTKs for the phorbol esters, 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced PLD activation in K562 and DT40 cells.	Tetradecanoylphorbol Acetate	87-123	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	138-141
11380624-2	2001	In this study, we investigated the roles of Syk and other PTKs for the phorbol esters, 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced PLD activation in K562 and DT40 cells.	Tetradecanoylphorbol Acetate	125-128	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	138-141
11380624-3	2001	RESULTS: TPA-induced PLD activation was remarkably reduced in both Syk dominant negative mutant K562 cells and Syk deficient DT40 B cells.	Tetradecanoylphorbol Acetate	9-12	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	21-24
11380624-5	2001	Similarly, TPA-induced PLD activation was reduced in Btk deficient cells, but unaffected in Lyn deficient cells.	Tetradecanoylphorbol Acetate	11-14	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	23-26
11380624-6	2001	Finally, in cells deficient in the PLC-gamma2, one of the phosphorylated substrates regulated by Syk and Btk, TPA-induced PLD activation, as well as phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis was remarkably reduced.	Tetradecanoylphorbol Acetate	110-113	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	122-125
11380624-7	2001	CONCLUSIONS: We demonstrated that the Syk, Btk and PLC-gamma2 pathways are required for TPA-induced PLD activation in DT40 cells.	Tetradecanoylphorbol Acetate	88-91	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	100-103
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	95-120	interleukin 1 beta	Homo sapiens	362-371
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	122-125	interleukin 1 beta	Homo sapiens	362-371
11295059-0	2001	Protein kinase C activation by PMA rapidly induces apoptosis through caspase-3/CPP32 and serine protease(s) in a gastric cancer cell line.	Tetradecanoylphorbol Acetate	31-34	caspase 3	Homo sapiens	79-84
11295059-0	2001	Protein kinase C activation by PMA rapidly induces apoptosis through caspase-3/CPP32 and serine protease(s) in a gastric cancer cell line.	Tetradecanoylphorbol Acetate	31-34	coagulation factor II, thrombin	Homo sapiens	89-104
11295059-2	2001	DNA ladder formation and caspase-3/CPP32 activation were observed in PMA treated cells indicating that PMA induces apoptosis.	Tetradecanoylphorbol Acetate	69-72	caspase 3	Homo sapiens	25-34
11295059-2	2001	DNA ladder formation and caspase-3/CPP32 activation were observed in PMA treated cells indicating that PMA induces apoptosis.	Tetradecanoylphorbol Acetate	69-72	caspase 3	Homo sapiens	35-40
11295059-8	2001	PMA-induced apoptosis appears to be mediated through activation of protein kinase C, and the activation of serine protease(s) and caspase-3/CPP32 may be the molecular mechanisms by which PMA induces apoptosis.	Tetradecanoylphorbol Acetate	0-3	coagulation factor II, thrombin	Homo sapiens	107-122
11699875-4	2001	TPA stimulated PI 3-kinase activity and increased the p85 subunit of PI 3-kinase immunoreactivity in anti-phosphotyrosine antibody-immunoprecipitated protein.	Tetradecanoylphorbol Acetate	0-3	WAP four-disulfide core domain 15B	Rattus norvegicus	15-19
11699875-4	2001	TPA stimulated PI 3-kinase activity and increased the p85 subunit of PI 3-kinase immunoreactivity in anti-phosphotyrosine antibody-immunoprecipitated protein.	Tetradecanoylphorbol Acetate	0-3	WAP four-disulfide core domain 15B	Rattus norvegicus	69-73
11699875-7	2001	Wortmannin also suppressed TPA-induced PI 3-kinase activity and PKCzeta activation but suppressed TPA-induced glucose uptake to only a small extent.	Tetradecanoylphorbol Acetate	27-30	WAP four-disulfide core domain 15B	Rattus norvegicus	39-43
11295059-8	2001	PMA-induced apoptosis appears to be mediated through activation of protein kinase C, and the activation of serine protease(s) and caspase-3/CPP32 may be the molecular mechanisms by which PMA induces apoptosis.	Tetradecanoylphorbol Acetate	0-3	caspase 3	Homo sapiens	130-139
11295059-8	2001	PMA-induced apoptosis appears to be mediated through activation of protein kinase C, and the activation of serine protease(s) and caspase-3/CPP32 may be the molecular mechanisms by which PMA induces apoptosis.	Tetradecanoylphorbol Acetate	0-3	caspase 3	Homo sapiens	140-145
11295059-8	2001	PMA-induced apoptosis appears to be mediated through activation of protein kinase C, and the activation of serine protease(s) and caspase-3/CPP32 may be the molecular mechanisms by which PMA induces apoptosis.	Tetradecanoylphorbol Acetate	187-190	coagulation factor II, thrombin	Homo sapiens	107-122
11329379-6	2001	This dissociation was not blocked by PP1 but was mimicked by the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	98-134	protein kinase C alpha	Homo sapiens	83-86
11295059-8	2001	PMA-induced apoptosis appears to be mediated through activation of protein kinase C, and the activation of serine protease(s) and caspase-3/CPP32 may be the molecular mechanisms by which PMA induces apoptosis.	Tetradecanoylphorbol Acetate	187-190	caspase 3	Homo sapiens	130-139
11329379-6	2001	This dissociation was not blocked by PP1 but was mimicked by the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	136-139	protein kinase C alpha	Homo sapiens	83-86
11329379-7	2001	Also, the PKC inhibitor GF109203X abolished both the LTD(4)- and the TPA-induced dissociation of vinculin from alpha-catenin.	Tetradecanoylphorbol Acetate	69-72	protein kinase C alpha	Homo sapiens	10-13
11295059-8	2001	PMA-induced apoptosis appears to be mediated through activation of protein kinase C, and the activation of serine protease(s) and caspase-3/CPP32 may be the molecular mechanisms by which PMA induces apoptosis.	Tetradecanoylphorbol Acetate	187-190	caspase 3	Homo sapiens	140-145
11312276-4	2001	TPA treatment leads to the rapid activation of extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK), the inactivation of p38 mitogen-activated protein kinase (MAPK), and the downregulation of PKCdelta.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	47-84
11312276-6	2001	Both p38 MAPK inactivation and JNK activation appear to be downstream of ERK because an agent that blocks ERK activation also blocks the modulation of these other MAP kinase family members by TPA treatment.	Tetradecanoylphorbol Acetate	192-195	mitogen-activated protein kinase 1	Homo sapiens	9-13
11312276-4	2001	TPA treatment leads to the rapid activation of extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK), the inactivation of p38 mitogen-activated protein kinase (MAPK), and the downregulation of PKCdelta.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	86-89
11312276-6	2001	Both p38 MAPK inactivation and JNK activation appear to be downstream of ERK because an agent that blocks ERK activation also blocks the modulation of these other MAP kinase family members by TPA treatment.	Tetradecanoylphorbol Acetate	192-195	mitogen-activated protein kinase 8	Homo sapiens	31-34
11312276-6	2001	Both p38 MAPK inactivation and JNK activation appear to be downstream of ERK because an agent that blocks ERK activation also blocks the modulation of these other MAP kinase family members by TPA treatment.	Tetradecanoylphorbol Acetate	192-195	mitogen-activated protein kinase 1	Homo sapiens	73-76
11319768-8	2001	These changes may be mediated by the cAMP or PKC pathways because both forskolin and TPA up-regulated the GFR alpha-1 gene.	Tetradecanoylphorbol Acetate	85-88	GDNF family receptor alpha 1	Rattus norvegicus	106-117
11312276-4	2001	TPA treatment leads to the rapid activation of extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK), the inactivation of p38 mitogen-activated protein kinase (MAPK), and the downregulation of PKCdelta.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	95-120
11319768-9	2001	Interestingly, only TPA led to a coordinated increase in the levels of GDNF, GFR alpha-1 and GFR alpha-2 mRNAs.	Tetradecanoylphorbol Acetate	20-23	GDNF family receptor alpha 1	Rattus norvegicus	77-88
11312276-6	2001	Both p38 MAPK inactivation and JNK activation appear to be downstream of ERK because an agent that blocks ERK activation also blocks the modulation of these other MAP kinase family members by TPA treatment.	Tetradecanoylphorbol Acetate	192-195	mitogen-activated protein kinase 1	Homo sapiens	106-109
11312276-4	2001	TPA treatment leads to the rapid activation of extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK), the inactivation of p38 mitogen-activated protein kinase (MAPK), and the downregulation of PKCdelta.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	122-125
11312276-4	2001	TPA treatment leads to the rapid activation of extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK), the inactivation of p38 mitogen-activated protein kinase (MAPK), and the downregulation of PKCdelta.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	148-184
11312276-4	2001	TPA treatment leads to the rapid activation of extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK), the inactivation of p38 mitogen-activated protein kinase (MAPK), and the downregulation of PKCdelta.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	186-190
11312276-5	2001	Inhibition of either ERK or JNK activation blocks TPA-mediated protection, whereas p38 MAPK and PKCdelta inhibitors block stress-induced nerve cell death.	Tetradecanoylphorbol Acetate	50-53	mitogen-activated protein kinase 1	Homo sapiens	21-24
11312276-6	2001	Both p38 MAPK inactivation and JNK activation appear to be downstream of ERK because an agent that blocks ERK activation also blocks the modulation of these other MAP kinase family members by TPA treatment.	Tetradecanoylphorbol Acetate	192-195	mitogen-activated protein kinase 14	Homo sapiens	5-8
11278385-0	2001	Extracellular signal-regulated kinase/90-KDA ribosomal S6 kinase/nuclear factor-kappa B pathway mediates phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	105-136	mitogen-activated protein kinase 1	Homo sapiens	0-37
11331935-6	2001	Phosphorylation of Cx43 was increased upon activation of protein kinase C (PKC) by 1 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	92-123	gap junction protein, alpha 1	Rattus norvegicus	19-23
11331935-6	2001	Phosphorylation of Cx43 was increased upon activation of protein kinase C (PKC) by 1 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	125-128	gap junction protein, alpha 1	Rattus norvegicus	19-23
11506188-3	2001	PMA induced the activation of the ERK pathway as assessed by determining the phosphorylation state of ERK and the upstream component MEK1/2.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	34-37
11506188-3	2001	PMA induced the activation of the ERK pathway as assessed by determining the phosphorylation state of ERK and the upstream component MEK1/2.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	102-105
11356008-3	2001	Here, we report that IL-6 and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically transactivate the IRE in HepG2 cells, which is coupled to a strong upregulation of c-Jun and c-Fos expression by TPA via the mitogen-activated protein kinase (MAPK) pathway.	Tetradecanoylphorbol Acetate	202-205	interleukin 6	Homo sapiens	21-25
11313461-2	2001	We have previously shown that, upon treatment of the pituitary cell line GH3B6 with thyrotropin-releasing hormone (TRH) or phorbol 12-myristate 13-acetate (PMA), human PKCalpha (hPKCalpha) is selectively targeted to the cell-cell contacts (42).	Tetradecanoylphorbol Acetate	123-154	protein kinase C alpha	Homo sapiens	168-176
11313461-2	2001	We have previously shown that, upon treatment of the pituitary cell line GH3B6 with thyrotropin-releasing hormone (TRH) or phorbol 12-myristate 13-acetate (PMA), human PKCalpha (hPKCalpha) is selectively targeted to the cell-cell contacts (42).	Tetradecanoylphorbol Acetate	123-154	protein kinase C alpha	Homo sapiens	178-187
11336804-8	2001	PLD activity was furthermore increased by 8Br-cAMP and following acute (30 min) stimulation of protein kinase C (PKC) with a phorbol ester (PMA).	Tetradecanoylphorbol Acetate	140-143	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
11278385-7	2001	Therefore, these results demonstrate that the sequential ERK/RSK1/NF-kappaB pathway mediates PMA-stimulated megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	93-96	nuclear factor kappa B subunit 1	Homo sapiens	66-75
11278385-1	2001	Two signaling pathways, the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK)-dependent pathway and the nuclear factor-kappaB (NF-kappaB)-dependent pathway, have been known to mediate megakaryocytic differentiation of K562 cells induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	274-305	mitogen-activated protein kinase 1	Homo sapiens	28-65
11278385-1	2001	Two signaling pathways, the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK)-dependent pathway and the nuclear factor-kappaB (NF-kappaB)-dependent pathway, have been known to mediate megakaryocytic differentiation of K562 cells induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	274-305	mitogen-activated protein kinase 1	Homo sapiens	67-70
11278385-1	2001	Two signaling pathways, the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK)-dependent pathway and the nuclear factor-kappaB (NF-kappaB)-dependent pathway, have been known to mediate megakaryocytic differentiation of K562 cells induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	274-305	nuclear factor kappa B subunit 1	Homo sapiens	138-159
11278385-1	2001	Two signaling pathways, the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK)-dependent pathway and the nuclear factor-kappaB (NF-kappaB)-dependent pathway, have been known to mediate megakaryocytic differentiation of K562 cells induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	274-305	nuclear factor kappa B subunit 1	Homo sapiens	161-170
11278385-1	2001	Two signaling pathways, the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK)-dependent pathway and the nuclear factor-kappaB (NF-kappaB)-dependent pathway, have been known to mediate megakaryocytic differentiation of K562 cells induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	307-310	mitogen-activated protein kinase 1	Homo sapiens	28-65
11278385-1	2001	Two signaling pathways, the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK)-dependent pathway and the nuclear factor-kappaB (NF-kappaB)-dependent pathway, have been known to mediate megakaryocytic differentiation of K562 cells induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	307-310	mitogen-activated protein kinase 1	Homo sapiens	67-70
11278385-1	2001	Two signaling pathways, the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK)-dependent pathway and the nuclear factor-kappaB (NF-kappaB)-dependent pathway, have been known to mediate megakaryocytic differentiation of K562 cells induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	307-310	nuclear factor kappa B subunit 1	Homo sapiens	138-159
11278385-1	2001	Two signaling pathways, the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK)-dependent pathway and the nuclear factor-kappaB (NF-kappaB)-dependent pathway, have been known to mediate megakaryocytic differentiation of K562 cells induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	307-310	nuclear factor kappa B subunit 1	Homo sapiens	161-170
11278385-6	2001	PMA-stimulated activation of ERK/MAPK, RSK1, and NF-kappaB and the PMA-induced megakaryocytic differentiation were prevented by pretreatment with PD98059, a specific inhibitor of the mitogen-activated ERK kinase (MEK).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	29-32
11278385-6	2001	PMA-stimulated activation of ERK/MAPK, RSK1, and NF-kappaB and the PMA-induced megakaryocytic differentiation were prevented by pretreatment with PD98059, a specific inhibitor of the mitogen-activated ERK kinase (MEK).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	33-37
11278385-6	2001	PMA-stimulated activation of ERK/MAPK, RSK1, and NF-kappaB and the PMA-induced megakaryocytic differentiation were prevented by pretreatment with PD98059, a specific inhibitor of the mitogen-activated ERK kinase (MEK).	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	49-58
11278385-6	2001	PMA-stimulated activation of ERK/MAPK, RSK1, and NF-kappaB and the PMA-induced megakaryocytic differentiation were prevented by pretreatment with PD98059, a specific inhibitor of the mitogen-activated ERK kinase (MEK).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 7	Homo sapiens	183-211
11278385-6	2001	PMA-stimulated activation of ERK/MAPK, RSK1, and NF-kappaB and the PMA-induced megakaryocytic differentiation were prevented by pretreatment with PD98059, a specific inhibitor of the mitogen-activated ERK kinase (MEK).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 7	Homo sapiens	213-216
11278385-6	2001	PMA-stimulated activation of ERK/MAPK, RSK1, and NF-kappaB and the PMA-induced megakaryocytic differentiation were prevented by pretreatment with PD98059, a specific inhibitor of the mitogen-activated ERK kinase (MEK).	Tetradecanoylphorbol Acetate	67-70	mitogen-activated protein kinase kinase 7	Homo sapiens	183-211
11278385-6	2001	PMA-stimulated activation of ERK/MAPK, RSK1, and NF-kappaB and the PMA-induced megakaryocytic differentiation were prevented by pretreatment with PD98059, a specific inhibitor of the mitogen-activated ERK kinase (MEK).	Tetradecanoylphorbol Acetate	67-70	mitogen-activated protein kinase kinase 7	Homo sapiens	213-216
11278385-7	2001	Therefore, these results demonstrate that the sequential ERK/RSK1/NF-kappaB pathway mediates PMA-stimulated megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	93-96	mitogen-activated protein kinase 1	Homo sapiens	57-60
11290614-2	2001	It was demonstrated that the priming of leukocytes with phorbol-12-myristate-13-acetate (PMA) leads to the increased formation of 5-lipoxygenase (5-LO) products in parallel with the increased association of 5-LO with the nucleus and the activation of kinases that can phosphorylate 5-LO in vitro.	Tetradecanoylphorbol Acetate	56-87	arachidonate 5-lipoxygenase	Homo sapiens	130-144
11795505-6	2001	We also investigated the effect of PYC on IL-2 gene expression in phorbol 12-myristate 13acetate plus ionomycin (PMA/Io)-stimulated human T-cell line Jurkat E6.1.	Tetradecanoylphorbol Acetate	66-96	interleukin 2	Homo sapiens	42-46
11290614-2	2001	It was demonstrated that the priming of leukocytes with phorbol-12-myristate-13-acetate (PMA) leads to the increased formation of 5-lipoxygenase (5-LO) products in parallel with the increased association of 5-LO with the nucleus and the activation of kinases that can phosphorylate 5-LO in vitro.	Tetradecanoylphorbol Acetate	89-92	arachidonate 5-lipoxygenase	Homo sapiens	130-144
11278336-3	2001	Ligands of PPARgamma inhibited phorbol ester (phorbol 12-myristate 13-acetate, PMA)-mediated induction of COX-2 and prostaglandin E(2) synthesis.	Tetradecanoylphorbol Acetate	46-77	peroxisome proliferator activated receptor gamma	Homo sapiens	11-20
11278336-3	2001	Ligands of PPARgamma inhibited phorbol ester (phorbol 12-myristate 13-acetate, PMA)-mediated induction of COX-2 and prostaglandin E(2) synthesis.	Tetradecanoylphorbol Acetate	46-77	prostaglandin-endoperoxide synthase 2	Homo sapiens	106-111
11278336-3	2001	Ligands of PPARgamma inhibited phorbol ester (phorbol 12-myristate 13-acetate, PMA)-mediated induction of COX-2 and prostaglandin E(2) synthesis.	Tetradecanoylphorbol Acetate	79-82	peroxisome proliferator activated receptor gamma	Homo sapiens	11-20
11278336-3	2001	Ligands of PPARgamma inhibited phorbol ester (phorbol 12-myristate 13-acetate, PMA)-mediated induction of COX-2 and prostaglandin E(2) synthesis.	Tetradecanoylphorbol Acetate	79-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	106-111
11278336-5	2001	PMA-mediated induction of COX-2 promoter activity was inhibited by PPARgamma ligands; this suppressive effect was prevented by overexpressing a dominant negative form of PPARgamma or a PPAR response element decoy oligonucleotide.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Homo sapiens	26-31
11278336-5	2001	PMA-mediated induction of COX-2 promoter activity was inhibited by PPARgamma ligands; this suppressive effect was prevented by overexpressing a dominant negative form of PPARgamma or a PPAR response element decoy oligonucleotide.	Tetradecanoylphorbol Acetate	0-3	peroxisome proliferator activated receptor gamma	Homo sapiens	67-76
11278336-5	2001	PMA-mediated induction of COX-2 promoter activity was inhibited by PPARgamma ligands; this suppressive effect was prevented by overexpressing a dominant negative form of PPARgamma or a PPAR response element decoy oligonucleotide.	Tetradecanoylphorbol Acetate	0-3	peroxisome proliferator activated receptor gamma	Homo sapiens	170-179
11278336-12	2001	Bisphenol A diglycidyl ether, a compound that binds to PPARgamma but lacks the ability to activate transcription, also inhibited PMA-mediated induction of AP-1 activity and COX-2.	Tetradecanoylphorbol Acetate	129-132	peroxisome proliferator activated receptor gamma	Homo sapiens	55-64
11278336-12	2001	Bisphenol A diglycidyl ether, a compound that binds to PPARgamma but lacks the ability to activate transcription, also inhibited PMA-mediated induction of AP-1 activity and COX-2.	Tetradecanoylphorbol Acetate	129-132	prostaglandin-endoperoxide synthase 2	Homo sapiens	173-178
11795505-6	2001	We also investigated the effect of PYC on IL-2 gene expression in phorbol 12-myristate 13acetate plus ionomycin (PMA/Io)-stimulated human T-cell line Jurkat E6.1.	Tetradecanoylphorbol Acetate	113-116	interleukin 2	Homo sapiens	42-46
11795505-7	2001	PYC inhibited the PMA/Io-induced IL-2 mRNA expression.	Tetradecanoylphorbol Acetate	18-21	interleukin 2	Homo sapiens	33-37
11795505-10	2001	We also found that PYC can destabilize PMA/Io-induced IL-2 mRNA by posttranscriptional regulation.	Tetradecanoylphorbol Acetate	39-42	interleukin 2	Homo sapiens	54-58
11285196-6	2001	ERK activity at 1 h post-TPA treatment was nearly 5-fold (P&lt; 0.005) above basal levels in AL mice while the increase was abolished in DER mice.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase 1	Mus musculus	0-3
11352632-4	2001	Exposure of acinar cells to phorbol myristate acetate (PMA), a phorbol ester activator of PKCdelta, also resulted in increased phosphorylation of PKCdelta and PYK2 isolated using anti-PKCdelta immunoprecipitation.	Tetradecanoylphorbol Acetate	28-53	protein tyrosine kinase 2 beta	Rattus norvegicus	159-163
11352632-4	2001	Exposure of acinar cells to phorbol myristate acetate (PMA), a phorbol ester activator of PKCdelta, also resulted in increased phosphorylation of PKCdelta and PYK2 isolated using anti-PKCdelta immunoprecipitation.	Tetradecanoylphorbol Acetate	55-58	protein tyrosine kinase 2 beta	Rattus norvegicus	159-163
11285196-7	2001	The TPA-induced ERK activity in AL mice was accompanied by increased phosphorylation of ERK1 and ERK2 (P&lt; 0.05), which was abrogated in DER mice.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase 1	Mus musculus	16-19
11285196-7	2001	The TPA-induced ERK activity in AL mice was accompanied by increased phosphorylation of ERK1 and ERK2 (P&lt; 0.05), which was abrogated in DER mice.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase 1	Mus musculus	97-101
11285196-12	2001	Taken together, our results indicated for the first time that DER blocked the TPA stimulation of ERK activity and suggested that the inhibition of TPA-induced AP-1 activity by DER is likely through inhibition of ERK but not JNK or p38 kinase pathway.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 1	Mus musculus	97-100
11285196-12	2001	Taken together, our results indicated for the first time that DER blocked the TPA stimulation of ERK activity and suggested that the inhibition of TPA-induced AP-1 activity by DER is likely through inhibition of ERK but not JNK or p38 kinase pathway.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 1	Mus musculus	212-215
11285196-12	2001	Taken together, our results indicated for the first time that DER blocked the TPA stimulation of ERK activity and suggested that the inhibition of TPA-induced AP-1 activity by DER is likely through inhibition of ERK but not JNK or p38 kinase pathway.	Tetradecanoylphorbol Acetate	147-150	mitogen-activated protein kinase 1	Mus musculus	97-100
11285196-12	2001	Taken together, our results indicated for the first time that DER blocked the TPA stimulation of ERK activity and suggested that the inhibition of TPA-induced AP-1 activity by DER is likely through inhibition of ERK but not JNK or p38 kinase pathway.	Tetradecanoylphorbol Acetate	147-150	mitogen-activated protein kinase 1	Mus musculus	212-215
11357893-3	2001	Our study shows PPARgamma to be preferentially expressed in the nuclei of resting T cells and to increase upon activation of T cells by either anti-CD3 and anti-CD28 or phorbol myristyl acetate (PMA).	Tetradecanoylphorbol Acetate	195-198	peroxisome proliferator activated receptor gamma	Homo sapiens	16-25
11359422-13	2001	The mechanism of IL-5 priming after PMA stimulation of oxygen radical production is MEK independent.	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase kinase 7	Homo sapiens	84-87
11328385-9	2001	Finally, we also show that B lymphocytes activated with CD40L/anti-mu or phorbol 12-myristate 13-acetate (PMA) express c-met receptor.	Tetradecanoylphorbol Acetate	73-104	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	119-124
11328385-9	2001	Finally, we also show that B lymphocytes activated with CD40L/anti-mu or phorbol 12-myristate 13-acetate (PMA) express c-met receptor.	Tetradecanoylphorbol Acetate	106-109	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	119-124
11357893-4	2001	We also found the PPARgamma ligand ciglitizone to attenuate the activation of T cells by inhibiting cytokine gene expression and anti-CD3 and anti-CD28 or PMA-induced proliferative responses.	Tetradecanoylphorbol Acetate	155-158	peroxisome proliferator activated receptor gamma	Homo sapiens	18-27
11241357-0	2001	A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	184-209	cyclin dependent kinase inhibitor 1A	Homo sapiens	149-152
11241357-0	2001	A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	184-209	cyclin dependent kinase inhibitor 1A	Homo sapiens	153-157
11241357-0	2001	A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	184-209	cyclin dependent kinase inhibitor 1A	Homo sapiens	158-162
11241357-4	2001	In the presence of DF, PMA-induced upregulation of the cyclin dependent kinase inhibitor (CDKI), p21(WAF1/CIP1), was blocked and its expression could be restored in the presence of DF by supplementation with ferric citrate.	Tetradecanoylphorbol Acetate	23-26	cyclin dependent kinase inhibitor 1A	Homo sapiens	97-100
11241357-4	2001	In the presence of DF, PMA-induced upregulation of the cyclin dependent kinase inhibitor (CDKI), p21(WAF1/CIP1), was blocked and its expression could be restored in the presence of DF by supplementation with ferric citrate.	Tetradecanoylphorbol Acetate	23-26	cyclin dependent kinase inhibitor 1A	Homo sapiens	101-105
11241357-4	2001	In the presence of DF, PMA-induced upregulation of the cyclin dependent kinase inhibitor (CDKI), p21(WAF1/CIP1), was blocked and its expression could be restored in the presence of DF by supplementation with ferric citrate.	Tetradecanoylphorbol Acetate	23-26	cyclin dependent kinase inhibitor 1A	Homo sapiens	106-110
11689104-6	2001	To complement the gene promoter studies, we determined the effects of a mixture of shikonins on phorbol 12-myristate 13-acetate (PMA)-mediated induction of COX-2 in transformed human mammary epithelial cells.	Tetradecanoylphorbol Acetate	96-127	prostaglandin-endoperoxide synthase 2	Homo sapiens	156-161
11689104-6	2001	To complement the gene promoter studies, we determined the effects of a mixture of shikonins on phorbol 12-myristate 13-acetate (PMA)-mediated induction of COX-2 in transformed human mammary epithelial cells.	Tetradecanoylphorbol Acetate	129-132	prostaglandin-endoperoxide synthase 2	Homo sapiens	156-161
11689104-8	2001	In transient transfections, PMA caused a severalfold increase in COX-2 promoter activity, an effect that was suppressed by shikonins.	Tetradecanoylphorbol Acetate	28-31	prostaglandin-endoperoxide synthase 2	Homo sapiens	65-70
11254678-4	2001	PMA also induces accumulation of cyclin D3-cdk4 complexes in B-2 cells; however, these complexes do not phosphorylate pRb.	Tetradecanoylphorbol Acetate	0-3	cyclin D3	Homo sapiens	33-42
11254678-5	2001	Thus, PMA is sufficient to induce synthesis and assembly of cyclin D3-cdk4 complexes in B-1 and B-2 cells; however, PMA triggers cyclin D3-cdk4 activation only in B-1 cells.	Tetradecanoylphorbol Acetate	6-9	cyclin D3	Homo sapiens	60-69
11254678-5	2001	Thus, PMA is sufficient to induce synthesis and assembly of cyclin D3-cdk4 complexes in B-1 and B-2 cells; however, PMA triggers cyclin D3-cdk4 activation only in B-1 cells.	Tetradecanoylphorbol Acetate	6-9	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	88-91
11254678-5	2001	Thus, PMA is sufficient to induce synthesis and assembly of cyclin D3-cdk4 complexes in B-1 and B-2 cells; however, PMA triggers cyclin D3-cdk4 activation only in B-1 cells.	Tetradecanoylphorbol Acetate	116-119	cyclin D3	Homo sapiens	129-138
11254678-5	2001	Thus, PMA is sufficient to induce synthesis and assembly of cyclin D3-cdk4 complexes in B-1 and B-2 cells; however, PMA triggers cyclin D3-cdk4 activation only in B-1 cells.	Tetradecanoylphorbol Acetate	116-119	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	163-166
11298136-9	2001	The results obtained during a three year period in the proliferation assays show an impaired PMA (phorbol myristate acetate) activation in specific T lymphocyte activation pathways (CD69, CD26, CD28, CD3, PHA, PWM and Con A mediated) but not in others (CD2, ionomycin, and Ig surface receptor).	Tetradecanoylphorbol Acetate	98-123	lamin B receptor	Homo sapiens	205-208
11259631-7	2001	Topical 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment of K5-PKC alpha mice resulted in a 5-fold increase in epidermal COX-2 induction and a 2- to 3-fold increase in prostaglandin (PG) E(2) levels above that observed in TPA-treated wild-type mice.	Tetradecanoylphorbol Acetate	8-44	protein kinase C, alpha	Mus musculus	67-76
11259631-7	2001	Topical 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment of K5-PKC alpha mice resulted in a 5-fold increase in epidermal COX-2 induction and a 2- to 3-fold increase in prostaglandin (PG) E(2) levels above that observed in TPA-treated wild-type mice.	Tetradecanoylphorbol Acetate	46-49	protein kinase C, alpha	Mus musculus	67-76
11124968-4	2001	In addition, reduction in CD45 expression caused the duration of peak PMA-induced MEK and extracellular signal-regulated kinase (ERK) 1/2 activity to increase from 5 min to 30 min while leading to a 4-fold increase in PMA-dependent PKCdelta activation.	Tetradecanoylphorbol Acetate	70-73	mitogen-activated protein kinase kinase 7	Homo sapiens	82-85
11124968-4	2001	In addition, reduction in CD45 expression caused the duration of peak PMA-induced MEK and extracellular signal-regulated kinase (ERK) 1/2 activity to increase from 5 min to 30 min while leading to a 4-fold increase in PMA-dependent PKCdelta activation.	Tetradecanoylphorbol Acetate	70-73	mitogen-activated protein kinase 3	Homo sapiens	90-137
11124968-6	2001	Finally, inhibitors of MEK (PD98059) and PKCdelta (rottlerin) completely blocked PMA-induced monocytic cell differentiation.	Tetradecanoylphorbol Acetate	81-84	mitogen-activated protein kinase kinase 7	Homo sapiens	23-26
11388701-7	2001	GF109203X, a protein kinase C inhibitor, and prolonged treatment with phorbol 12-myristate 13-acetate partially inhibited p38 MAPK activation.	Tetradecanoylphorbol Acetate	70-101	mitogen-activated protein kinase 14	Homo sapiens	122-125
11388701-7	2001	GF109203X, a protein kinase C inhibitor, and prolonged treatment with phorbol 12-myristate 13-acetate partially inhibited p38 MAPK activation.	Tetradecanoylphorbol Acetate	70-101	mitogen-activated protein kinase 1	Homo sapiens	126-130
11069897-2	2001	Bach1 forms a heterodimer with MafK, a member of the small Maf protein family (MafF, MafG, and MafK), which recognizes the NF-E2/Maf recognition element, a cis-regulatory motif containing a 12-O-tetradecanoylphorbol-13-acetate-responsive element.	Tetradecanoylphorbol Acetate	190-226	BTB domain and CNC homolog 1	Homo sapiens	0-5
11069897-2	2001	Bach1 forms a heterodimer with MafK, a member of the small Maf protein family (MafF, MafG, and MafK), which recognizes the NF-E2/Maf recognition element, a cis-regulatory motif containing a 12-O-tetradecanoylphorbol-13-acetate-responsive element.	Tetradecanoylphorbol Acetate	190-226	MAF bZIP transcription factor	Homo sapiens	31-34
11069897-2	2001	Bach1 forms a heterodimer with MafK, a member of the small Maf protein family (MafF, MafG, and MafK), which recognizes the NF-E2/Maf recognition element, a cis-regulatory motif containing a 12-O-tetradecanoylphorbol-13-acetate-responsive element.	Tetradecanoylphorbol Acetate	190-226	MAF bZIP transcription factor G	Homo sapiens	85-89
11069897-2	2001	Bach1 forms a heterodimer with MafK, a member of the small Maf protein family (MafF, MafG, and MafK), which recognizes the NF-E2/Maf recognition element, a cis-regulatory motif containing a 12-O-tetradecanoylphorbol-13-acetate-responsive element.	Tetradecanoylphorbol Acetate	190-226	nuclear factor, erythroid 2	Homo sapiens	123-128
11069897-2	2001	Bach1 forms a heterodimer with MafK, a member of the small Maf protein family (MafF, MafG, and MafK), which recognizes the NF-E2/Maf recognition element, a cis-regulatory motif containing a 12-O-tetradecanoylphorbol-13-acetate-responsive element.	Tetradecanoylphorbol Acetate	190-226	MAF bZIP transcription factor	Homo sapiens	59-62
11313866-0	2001	Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1.	Tetradecanoylphorbol Acetate	85-88	cyclin dependent kinase inhibitor 1A	Homo sapiens	16-19
11313866-0	2001	Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1.	Tetradecanoylphorbol Acetate	85-88	cyclin dependent kinase inhibitor 1A	Homo sapiens	20-24
11313866-0	2001	Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1.	Tetradecanoylphorbol Acetate	85-88	cyclin dependent kinase inhibitor 1A	Homo sapiens	25-29
11313866-3	2001	TPA-induced differentiation and growth arrest of TSU-Pr1 cells were inhibited by treatment with Protein kinase C (PKC) inhibitor GF109203X and mitogen-activated protein (MAP) kinase inhibitor PD98059.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	114-117
11313866-4	2001	Treatment of TSU-Pr1 cells with TPA for 15 min or longer resulted in translocation of PKCalpha, PKCgamma, and PKCepsilon from cytosolic to membrane fraction.	Tetradecanoylphorbol Acetate	32-35	protein kinase C alpha	Homo sapiens	86-94
11313866-5	2001	Our results suggest that TPA-induced TSU-Pr1 cell differentiation is associated with activation of MAP kinase and PKCalpha, PKCgamma, and PKCepsilon.	Tetradecanoylphorbol Acetate	25-28	protein kinase C alpha	Homo sapiens	114-122
11313866-9	2001	Thus, our results indicate that p21(WAF1/CIP1) mediates TPA-induced growth arrest and differentiation of TSU-Pr1 cells.	Tetradecanoylphorbol Acetate	56-59	cyclin dependent kinase inhibitor 1A	Homo sapiens	32-35
11313866-9	2001	Thus, our results indicate that p21(WAF1/CIP1) mediates TPA-induced growth arrest and differentiation of TSU-Pr1 cells.	Tetradecanoylphorbol Acetate	56-59	cyclin dependent kinase inhibitor 1A	Homo sapiens	36-40
11313866-9	2001	Thus, our results indicate that p21(WAF1/CIP1) mediates TPA-induced growth arrest and differentiation of TSU-Pr1 cells.	Tetradecanoylphorbol Acetate	56-59	cyclin dependent kinase inhibitor 1A	Homo sapiens	41-45
11262186-6	2001	We show that TPA treatment induces the PKC-dependent association of tyrosine-phosphorylated Cas with Crk.	Tetradecanoylphorbol Acetate	13-16	CRK proto-oncogene, adaptor protein	Homo sapiens	101-104
11262186-7	2001	The activity of two protein tyrosine kinases, Src and FAK, was shown to be necessary and sufficient for TPA-induced Cas phosphorylation.	Tetradecanoylphorbol Acetate	104-107	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	46-49
11273665-10	2001	PP1 activity increased 38+/-8% in cells exposed to 1 microM PMA for 5 min.	Tetradecanoylphorbol Acetate	60-63	neuropeptide Y receptor Y4	Homo sapiens	0-3
11388647-6	2001	When phorbol 12-myristate 13-acetate-treated THP-1 and J774A.1 cells were incubated in the medium containing 20% of serum from rats administered R-755, the ACAT activities of the cells were inhibited.	Tetradecanoylphorbol Acetate	5-36	GLI family zinc finger 2	Homo sapiens	45-50
11310793-8	2001	Studies using inhibitors for protein kinases involved in cell signaling pathways suggested that stress-activated kinase p38 and mitogen-activated protein kinase kinase MEK are involved in TPA-independent regulation of TYRP2 expression in melanocytes.	Tetradecanoylphorbol Acetate	188-191	mitogen-activated protein kinase kinase 7	Homo sapiens	168-171
11134023-4	2001	This defective inside-out integrin activation is only restricted to beta(2) integrins, since beta(1) integrins expressed in K562 readily respond to activation signals, such as phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	176-207	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	93-100
11238119-7	2001	Moreover, the generation of NK1.1+ T cells with invariant Valpha14Jalpha281 chains was induced from the NK1.1+ CD3- thymocytes following stimulation with phorbol myristate acetate and ionomycin in a neonatal thymic organ culture.	Tetradecanoylphorbol Acetate	154-179	CD247 antigen	Mus musculus	111-114
11166910-3	2001	iNOS promoter-dependent reporter gene activity was significantly increased by TPA, and the TPA-induced increase of the reporter gene activity was efficiently reduced by costunolide, with an IC50 of approximately 2 microM.	Tetradecanoylphorbol Acetate	78-81	nitric oxide synthase 2	Homo sapiens	0-4
11166910-3	2001	iNOS promoter-dependent reporter gene activity was significantly increased by TPA, and the TPA-induced increase of the reporter gene activity was efficiently reduced by costunolide, with an IC50 of approximately 2 microM.	Tetradecanoylphorbol Acetate	91-94	nitric oxide synthase 2	Homo sapiens	0-4
11290857-7	2001	TNF-alpha production was induced by lipopolysaccharide and phorbol myristate acetate and quantitated by enzyme-linked immunosorbent assay.	Tetradecanoylphorbol Acetate	59-84	tumor necrosis factor	Homo sapiens	0-9
11290857-9	2001	RESULTS: Acute EtOH initially inhibited lipopolysaccharide/phorbol myristate acetate-induced TNF-alpha production in Mono Mac 6 cells.	Tetradecanoylphorbol Acetate	59-84	tumor necrosis factor	Homo sapiens	93-102
11181529-5	2001	We now demonstrate that PMA-induced hydroxamate (IC3)-inhibitable GHR proteolysis and GHBP shedding were also detected in murine 3T3-F442A and 3T3-L1 preadipocytes and in Chinese hamster ovary (CHO) cells stably expressing rabbit GHR (rbGHR), although the degree of GHBP shedding was much smaller for murine GHR than for rabbit or human GHRs.	Tetradecanoylphorbol Acetate	24-27	growth hormone receptor	Mus musculus	66-69
11181529-5	2001	We now demonstrate that PMA-induced hydroxamate (IC3)-inhibitable GHR proteolysis and GHBP shedding were also detected in murine 3T3-F442A and 3T3-L1 preadipocytes and in Chinese hamster ovary (CHO) cells stably expressing rabbit GHR (rbGHR), although the degree of GHBP shedding was much smaller for murine GHR than for rabbit or human GHRs.	Tetradecanoylphorbol Acetate	24-27	growth hormone receptor	Mus musculus	86-90
11181532-9	2001	Studies also show that Dmrt1 expression was inhibited by phorbol esters (PMA) but only modestly effected by serum.	Tetradecanoylphorbol Acetate	73-76	doublesex and mab-3 related transcription factor 1	Rattus norvegicus	23-28
11181529-5	2001	We now demonstrate that PMA-induced hydroxamate (IC3)-inhibitable GHR proteolysis and GHBP shedding were also detected in murine 3T3-F442A and 3T3-L1 preadipocytes and in Chinese hamster ovary (CHO) cells stably expressing rabbit GHR (rbGHR), although the degree of GHBP shedding was much smaller for murine GHR than for rabbit or human GHRs.	Tetradecanoylphorbol Acetate	24-27	growth hormone receptor	Mus musculus	266-270
11181529-5	2001	We now demonstrate that PMA-induced hydroxamate (IC3)-inhibitable GHR proteolysis and GHBP shedding were also detected in murine 3T3-F442A and 3T3-L1 preadipocytes and in Chinese hamster ovary (CHO) cells stably expressing rabbit GHR (rbGHR), although the degree of GHBP shedding was much smaller for murine GHR than for rabbit or human GHRs.	Tetradecanoylphorbol Acetate	24-27	growth hormone receptor	Mus musculus	230-233
11181529-6	2001	PMA-induced GHR proteolysis in 3T3-F442A, 3T3-L1, and CHO-rbGHR cells was significantly reduced by pretreatment with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1 inhibitors, suggesting involvement of the mitogen-activated protein kinase pathway in regulating this PKC-dependent effect.	Tetradecanoylphorbol Acetate	0-3	growth hormone receptor	Mus musculus	12-15
11226820-4	2001	The pharmacodynamic aspect, based on the ability to inhibit cyclooxygenase-2 (COX-2) in vitro, was determined by incubating human dermal fibroblasts in culture, pre-treated with phobol-12-myristate-13-acetate (PMA) for 6 h, with 25 microM [(14)C]-arachidonic acid (AA) in the presence of several drug concentrations.	Tetradecanoylphorbol Acetate	210-213	prostaglandin-endoperoxide synthase 2	Homo sapiens	60-76
11226820-4	2001	The pharmacodynamic aspect, based on the ability to inhibit cyclooxygenase-2 (COX-2) in vitro, was determined by incubating human dermal fibroblasts in culture, pre-treated with phobol-12-myristate-13-acetate (PMA) for 6 h, with 25 microM [(14)C]-arachidonic acid (AA) in the presence of several drug concentrations.	Tetradecanoylphorbol Acetate	210-213	prostaglandin-endoperoxide synthase 2	Homo sapiens	78-83
11288761-7	2001	Addition of phorbol 12-myristate 13-acetate to the cultures rendered the cells resistant to dexamethasone with regard to proliferation and IL-10 and IFN-gamma production, but not to IL-2 and TNF-alpha production in both patients and controls.	Tetradecanoylphorbol Acetate	12-43	interferon gamma	Homo sapiens	149-158
11169972-5	2001	p70s6K, an important kinase involved in the regulation of protein synthesis and cell-cycle progression, has been reported to be activated through a PKC-dependent pathway (TPA-activatable) in addition to a PI3K-dependent pathway.	Tetradecanoylphorbol Acetate	171-174	protein kinase C, alpha	Mus musculus	148-151
11238213-3	2001	We found that the number of PBMCs stained for tumor necrosis factor alpha and gamma interferon after 6 h of activation was higher when PMA-ionomycin was used for stimulation, while the frequencies of cells positive for interleukin 4 (IL-4) were similar for both stimulators.	Tetradecanoylphorbol Acetate	135-138	tumor necrosis factor	Homo sapiens	46-73
11487146-4	2001	Furthermore the tPA mRNA level had increased in HDP cells treated with TNF-alpha, as determined by reverse transcription-polymerase chain reaction, but urokinase PA and PA inhibitor-1 mRNA levels did not increase.	Tetradecanoylphorbol Acetate	16-19	tumor necrosis factor	Homo sapiens	71-80
11487146-7	2001	The present results suggested that TNF-alpha stimulates PA activity via an enhancement of tPA gene expression in HDP cells and MMP-2 activity, and further that tPA-activated TNF-alpha stimulated MMP-9.	Tetradecanoylphorbol Acetate	90-93	tumor necrosis factor	Homo sapiens	35-44
11487146-7	2001	The present results suggested that TNF-alpha stimulates PA activity via an enhancement of tPA gene expression in HDP cells and MMP-2 activity, and further that tPA-activated TNF-alpha stimulated MMP-9.	Tetradecanoylphorbol Acetate	160-163	tumor necrosis factor	Homo sapiens	35-44
11487146-7	2001	The present results suggested that TNF-alpha stimulates PA activity via an enhancement of tPA gene expression in HDP cells and MMP-2 activity, and further that tPA-activated TNF-alpha stimulated MMP-9.	Tetradecanoylphorbol Acetate	160-163	tumor necrosis factor	Homo sapiens	174-183
11160743-1	2001	Expression of the lytic cycle genes of Epstain-Barr virus (EBV) is induced in type I Burkitt"s lymphoma-derived cells by treatment with phorbol esters (e.g., phorbol myristate acetate [PMA]), anti-immunoglobulin, or the cytokine transforming growth factor beta (TGF-beta).	Tetradecanoylphorbol Acetate	158-183	transforming growth factor beta 1	Homo sapiens	229-260
11160755-6	2001	In addition, we demonstrate that IKA is also capable of efficiently blocking CD4 down-modulation in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	112-137	CD4 molecule	Homo sapiens	77-80
11411021-5	2001	RESULTS: Phorbol-12-myristate-13-acetate significantly upregulated the nephrin expression in A293 cells, while no change was found after treatment with additional stimulants for other main signalling pathways, e.g. okadaic acid, lysophosphatidic acid, bradykinin, angiotensin II (ANG II) and arginine vasopressin (AVP).	Tetradecanoylphorbol Acetate	9-40	kininogen 1	Homo sapiens	252-262
11411021-5	2001	RESULTS: Phorbol-12-myristate-13-acetate significantly upregulated the nephrin expression in A293 cells, while no change was found after treatment with additional stimulants for other main signalling pathways, e.g. okadaic acid, lysophosphatidic acid, bradykinin, angiotensin II (ANG II) and arginine vasopressin (AVP).	Tetradecanoylphorbol Acetate	9-40	angiotensinogen	Homo sapiens	264-278
11411021-5	2001	RESULTS: Phorbol-12-myristate-13-acetate significantly upregulated the nephrin expression in A293 cells, while no change was found after treatment with additional stimulants for other main signalling pathways, e.g. okadaic acid, lysophosphatidic acid, bradykinin, angiotensin II (ANG II) and arginine vasopressin (AVP).	Tetradecanoylphorbol Acetate	9-40	angiotensinogen	Homo sapiens	280-286
11411021-5	2001	RESULTS: Phorbol-12-myristate-13-acetate significantly upregulated the nephrin expression in A293 cells, while no change was found after treatment with additional stimulants for other main signalling pathways, e.g. okadaic acid, lysophosphatidic acid, bradykinin, angiotensin II (ANG II) and arginine vasopressin (AVP).	Tetradecanoylphorbol Acetate	9-40	arginine vasopressin	Homo sapiens	301-312
11160743-1	2001	Expression of the lytic cycle genes of Epstain-Barr virus (EBV) is induced in type I Burkitt"s lymphoma-derived cells by treatment with phorbol esters (e.g., phorbol myristate acetate [PMA]), anti-immunoglobulin, or the cytokine transforming growth factor beta (TGF-beta).	Tetradecanoylphorbol Acetate	158-183	transforming growth factor beta 1	Homo sapiens	262-270
11179453-4	2001	Partial inhibition of the angiotensin II-induced calcium response was observed when cells were pretreated with dibutyryl cyclic AMP, tetradecanoyl phorbol acetate (TPA), vasopressin, or lysophosphatidic acid.	Tetradecanoylphorbol Acetate	133-162	angiotensinogen	Rattus norvegicus	26-40
11179453-4	2001	Partial inhibition of the angiotensin II-induced calcium response was observed when cells were pretreated with dibutyryl cyclic AMP, tetradecanoyl phorbol acetate (TPA), vasopressin, or lysophosphatidic acid.	Tetradecanoylphorbol Acetate	164-167	angiotensinogen	Rattus norvegicus	26-40
11710560-7	2001	Chemical stimulation by glycidyl methatylate (GMA) and phorbol 12-o-tetradecanoate 13-acetate (TPA) analysis revealed that induction of rGSTP1 expression was mainly through GPEI.	Tetradecanoylphorbol Acetate	95-98	glutathione S-transferase pi 1	Rattus norvegicus	136-142
11238929-4	2001	Phorbol 12-myristate 13-acetate (PMA)-induced differentiation of the promonocytic cell line U937 leads to persistent NF-kappaB nuclear translocation.	Tetradecanoylphorbol Acetate	0-31	nuclear factor kappa B subunit 1	Homo sapiens	117-126
11238929-4	2001	Phorbol 12-myristate 13-acetate (PMA)-induced differentiation of the promonocytic cell line U937 leads to persistent NF-kappaB nuclear translocation.	Tetradecanoylphorbol Acetate	33-36	nuclear factor kappa B subunit 1	Homo sapiens	117-126
11238929-6	2001	Promonocytic cells stably overexpressing an IkappaBalpha transgene containing SRD mutations fail to activate NF-kappaB and subsequently fail to survive the PMA-induced macrophage differentiation program.	Tetradecanoylphorbol Acetate	156-159	NFKB inhibitor alpha	Homo sapiens	44-56
11281019-6	2001	However, the expression of IL-10 messenger RNA (mRNA) was induced 24 h after UVB irradiation (300 J/m2) and that of TNF-alpha mRNA occurred 6 h after treatment with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	165-190	interleukin 10	Mus musculus	27-32
11281019-6	2001	However, the expression of IL-10 messenger RNA (mRNA) was induced 24 h after UVB irradiation (300 J/m2) and that of TNF-alpha mRNA occurred 6 h after treatment with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	165-190	tumor necrosis factor	Mus musculus	116-125
11222091-0	2001	Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C. We have previously demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) activates human T-cell leukemia virus type-I long terminal repeat (LTR) in Jurkat cells by a protein kinase C (PKC)-independent mechanism involving a posttranslational activation of Sp1 binding to an Sp1 site located within the Ets responsive region-1 (ERR-1).	Tetradecanoylphorbol Acetate	76-112	tumor protein p53	Homo sapiens	4-7
11297035-11	2001	Finally, the expression level of CD40L was shown to be upregulated by phorbol myristate acetate (PMA) in the promegakaryocytic cell line MEG-01.	Tetradecanoylphorbol Acetate	70-95	CD40 ligand	Homo sapiens	33-38
11297035-11	2001	Finally, the expression level of CD40L was shown to be upregulated by phorbol myristate acetate (PMA) in the promegakaryocytic cell line MEG-01.	Tetradecanoylphorbol Acetate	97-100	CD40 ligand	Homo sapiens	33-38
11222091-0	2001	Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C. We have previously demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) activates human T-cell leukemia virus type-I long terminal repeat (LTR) in Jurkat cells by a protein kinase C (PKC)-independent mechanism involving a posttranslational activation of Sp1 binding to an Sp1 site located within the Ets responsive region-1 (ERR-1).	Tetradecanoylphorbol Acetate	76-112	protein kinase C alpha	Homo sapiens	345-348
11222091-0	2001	Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C. We have previously demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) activates human T-cell leukemia virus type-I long terminal repeat (LTR) in Jurkat cells by a protein kinase C (PKC)-independent mechanism involving a posttranslational activation of Sp1 binding to an Sp1 site located within the Ets responsive region-1 (ERR-1).	Tetradecanoylphorbol Acetate	191-227	tumor protein p53	Homo sapiens	4-7
11222091-0	2001	Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C. We have previously demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) activates human T-cell leukemia virus type-I long terminal repeat (LTR) in Jurkat cells by a protein kinase C (PKC)-independent mechanism involving a posttranslational activation of Sp1 binding to an Sp1 site located within the Ets responsive region-1 (ERR-1).	Tetradecanoylphorbol Acetate	191-227	protein kinase C alpha	Homo sapiens	345-348
11222091-0	2001	Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C. We have previously demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) activates human T-cell leukemia virus type-I long terminal repeat (LTR) in Jurkat cells by a protein kinase C (PKC)-independent mechanism involving a posttranslational activation of Sp1 binding to an Sp1 site located within the Ets responsive region-1 (ERR-1).	Tetradecanoylphorbol Acetate	229-232	tumor protein p53	Homo sapiens	4-7
11222091-1	2001	By employing the PKC inhibitor, bisindolylmaleimide I and cotransfecting the reporter LTR construct with a vector expressing PKC-alpha, we demonstrated, in the present study, that this effect of TPA was not only independent of, but actually antagonized by, PKC.	Tetradecanoylphorbol Acetate	195-198	protein kinase C alpha	Homo sapiens	17-20
11222091-1	2001	By employing the PKC inhibitor, bisindolylmaleimide I and cotransfecting the reporter LTR construct with a vector expressing PKC-alpha, we demonstrated, in the present study, that this effect of TPA was not only independent of, but actually antagonized by, PKC.	Tetradecanoylphorbol Acetate	195-198	protein kinase C alpha	Homo sapiens	125-134
11222091-1	2001	By employing the PKC inhibitor, bisindolylmaleimide I and cotransfecting the reporter LTR construct with a vector expressing PKC-alpha, we demonstrated, in the present study, that this effect of TPA was not only independent of, but actually antagonized by, PKC.	Tetradecanoylphorbol Acetate	195-198	protein kinase C alpha	Homo sapiens	125-128
11222091-8	2001	Therefore, we speculate that there might be several other PKC-independent biological effects of TPA which result from interaction of such Sp1-p53 complexes with Sp1 recognition sites residing in the promoters of a wide variety of cellular and viral genes.	Tetradecanoylphorbol Acetate	96-99	protein kinase C alpha	Homo sapiens	58-61
11222091-8	2001	Therefore, we speculate that there might be several other PKC-independent biological effects of TPA which result from interaction of such Sp1-p53 complexes with Sp1 recognition sites residing in the promoters of a wide variety of cellular and viral genes.	Tetradecanoylphorbol Acetate	96-99	tumor protein p53	Homo sapiens	142-145
11158990-7	2001	ACE induction by VEGF was inhibited by the selective protein kinase C (PKC) inhibitor GF109203X (2.5 x 10(-3) mmol/l) and by downregulating PKC with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	149-180	angiotensin I converting enzyme	Homo sapiens	0-3
11165771-4	2001	NO release/iNOS expression in IFN-gamma -treated BV2 cells was reduced in the presence of PKC inhibitors (Go 6976 and BIM), and by long-term pre-treatment (48 h) of cells with phorbol-12-myristate-13-acetate (PMA) or thymeleatoxin.	Tetradecanoylphorbol Acetate	176-207	nitric oxide synthase 2, inducible	Mus musculus	11-15
11165771-4	2001	NO release/iNOS expression in IFN-gamma -treated BV2 cells was reduced in the presence of PKC inhibitors (Go 6976 and BIM), and by long-term pre-treatment (48 h) of cells with phorbol-12-myristate-13-acetate (PMA) or thymeleatoxin.	Tetradecanoylphorbol Acetate	176-207	interferon gamma	Mus musculus	30-39
11165771-4	2001	NO release/iNOS expression in IFN-gamma -treated BV2 cells was reduced in the presence of PKC inhibitors (Go 6976 and BIM), and by long-term pre-treatment (48 h) of cells with phorbol-12-myristate-13-acetate (PMA) or thymeleatoxin.	Tetradecanoylphorbol Acetate	209-212	nitric oxide synthase 2, inducible	Mus musculus	11-15
11165771-4	2001	NO release/iNOS expression in IFN-gamma -treated BV2 cells was reduced in the presence of PKC inhibitors (Go 6976 and BIM), and by long-term pre-treatment (48 h) of cells with phorbol-12-myristate-13-acetate (PMA) or thymeleatoxin.	Tetradecanoylphorbol Acetate	209-212	interferon gamma	Mus musculus	30-39
11253165-7	2001	The inhibitory effect of AVP on the apoptosis was reduced by staurosporine and mimicked by phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	91-122	arginine vasopressin	Rattus norvegicus	25-28
11080494-3	2001	Quantitation by RNase protection assay showed maximal increases of 3.4-, 3.0-, 3.8-, and 4.9-fold in relative 5-HT(1A) mRNA levels after 48 h of stimulation of splenocytes with lipopolysaccharide, phytohemagglutinin, concanavalin A, or phorbol 12-myristate 13-acetate plus ionomycin, respectively, as compared with unstimulated cells.	Tetradecanoylphorbol Acetate	236-267	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	110-117
11158990-7	2001	ACE induction by VEGF was inhibited by the selective protein kinase C (PKC) inhibitor GF109203X (2.5 x 10(-3) mmol/l) and by downregulating PKC with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	149-180	vascular endothelial growth factor A	Homo sapiens	17-21
11221888-7	2001	Finally, both phorbol 12-myristate 13-acetate and the diacylglycerol analogue 1,2-dioctanoyl-sn-glycerol induced redistribution of RasGRP3 to the plasma membrane and/or perinuclear area in HEK-293 cells, as demonstrated using a green fluorescent fusion protein.	Tetradecanoylphorbol Acetate	14-45	RAS guanyl releasing protein 3	Homo sapiens	131-138
11181442-1	2001	12-O:-tetradecanoylphorbol-13-acetate (TPA) inhibits gap junctional communication in many cell culture systems, but TPA-induced phosphorylation of the gap junction protein connexin43 (Cx43) varies much between systems.	Tetradecanoylphorbol Acetate	116-119	gap junction protein, alpha 1	Rattus norvegicus	172-182
11181442-1	2001	12-O:-tetradecanoylphorbol-13-acetate (TPA) inhibits gap junctional communication in many cell culture systems, but TPA-induced phosphorylation of the gap junction protein connexin43 (Cx43) varies much between systems.	Tetradecanoylphorbol Acetate	116-119	gap junction protein, alpha 1	Rattus norvegicus	184-188
11156939-2	2001	We used a serum-starved human foreskin fibroblast model to determine changes in COX-2 mRNA, protein, and promoter activity in response to stimulation with interleukin-1b (IL-1b) and phorbol 12-myristate 13-acetate (PMA) at G0, G1, S and G2/M phases of the cell cycle.	Tetradecanoylphorbol Acetate	182-213	prostaglandin-endoperoxide synthase 2	Homo sapiens	80-85
11207652-8	2001	Intracytoplasmic staining of cell lines after phorbol myristate acetate stimulation resulted in dominance of interferon-gamma (IFN-gamma)-IL-4 double-positive cells, whereas antigen stimulation resulted in production of IFN-gamma only.	Tetradecanoylphorbol Acetate	46-71	interferon gamma	Homo sapiens	109-125
11207652-8	2001	Intracytoplasmic staining of cell lines after phorbol myristate acetate stimulation resulted in dominance of interferon-gamma (IFN-gamma)-IL-4 double-positive cells, whereas antigen stimulation resulted in production of IFN-gamma only.	Tetradecanoylphorbol Acetate	46-71	interferon gamma	Homo sapiens	127-136
11179965-9	2001	In contrast, enforced tPACRE-binding activity of CREB in HeLa cells significantly reduced the magnitude of PMA-mediated induction of t-PA mRNA in HeLa cells.	Tetradecanoylphorbol Acetate	107-110	plasminogen activator, tissue type	Homo sapiens	133-137
11156944-0	2001	Reactive oxygen species mediate tumor necrosis factor alpha-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	120-145	tumor necrosis factor	Homo sapiens	32-59
11160199-7	2001	These data indicated that TACE is required for the TPA-induced M-CSFR cleavage.	Tetradecanoylphorbol Acetate	51-54	a disintegrin and metallopeptidase domain 17	Mus musculus	26-30
11156969-4	2001	Prestimulation of macrophages for 15 h with a combination of LPS/IFN-gamma attenuated oxygen radical formation in response to TPA.	Tetradecanoylphorbol Acetate	126-129	interferon gamma	Homo sapiens	65-74
11156969-7	2001	We demonstrated that PPRE decoy oligonucleotides, supplied in front of LPS/IFN-gamma, allowed a full oxidative burst to recover upon TPA addition.	Tetradecanoylphorbol Acetate	133-136	interferon gamma	Homo sapiens	75-84
11174192-10	2001	Ionomycin induced IL-4 secretion by BAL basophils, and this response was reduced with the addition of phorbol myristate acetate.	Tetradecanoylphorbol Acetate	102-127	interleukin 4	Homo sapiens	18-22
11174192-11	2001	In contrast, phorbol myristate acetate promoted the secretion of IL-4 by BAL cells enriched for lymphocytes; both findings are identical to those reported for basophils and lymphocytes purified from blood.	Tetradecanoylphorbol Acetate	13-38	interleukin 4	Homo sapiens	65-69
11182772-9	2001	The inhibition of the Na+/K+ATPase activity was dependent on protein kinase C (PKC) activation since PKC antagonists (calphostin C and staurosporine) abolished the inhibitory effect of Ang II, and the PKC activator phorbol 12-myristate 13-acetate reduced transporter activity.	Tetradecanoylphorbol Acetate	215-246	protein kinase C alpha	Homo sapiens	79-82
11182772-9	2001	The inhibition of the Na+/K+ATPase activity was dependent on protein kinase C (PKC) activation since PKC antagonists (calphostin C and staurosporine) abolished the inhibitory effect of Ang II, and the PKC activator phorbol 12-myristate 13-acetate reduced transporter activity.	Tetradecanoylphorbol Acetate	215-246	protein kinase C alpha	Homo sapiens	101-104
11182772-9	2001	The inhibition of the Na+/K+ATPase activity was dependent on protein kinase C (PKC) activation since PKC antagonists (calphostin C and staurosporine) abolished the inhibitory effect of Ang II, and the PKC activator phorbol 12-myristate 13-acetate reduced transporter activity.	Tetradecanoylphorbol Acetate	215-246	protein kinase C alpha	Homo sapiens	101-104
11230335-7	2001	Direct activation of PKC by phorbol 12-myristate13-acetate (PMA; 10(-7) mol/L) caused a contraction similar in magnitude and time course to ox-LDL-induced contraction and enhanced 5-HT- and KCl-induced contraction with no additional increases in [Ca(2+)](i).	Tetradecanoylphorbol Acetate	28-58	protein kinase C alpha	Homo sapiens	21-24
11230335-7	2001	Direct activation of PKC by phorbol 12-myristate13-acetate (PMA; 10(-7) mol/L) caused a contraction similar in magnitude and time course to ox-LDL-induced contraction and enhanced 5-HT- and KCl-induced contraction with no additional increases in [Ca(2+)](i).	Tetradecanoylphorbol Acetate	60-63	protein kinase C alpha	Homo sapiens	21-24
11230335-9	2001	Both ox-LDL and PMA caused an increase in PKC activity in the particulate fraction, a decrease in the cytosolic fraction, and an increase in the particulate/cytosolic PKC activity ratio.	Tetradecanoylphorbol Acetate	16-19	protein kinase C alpha	Homo sapiens	42-45
11230335-9	2001	Both ox-LDL and PMA caused an increase in PKC activity in the particulate fraction, a decrease in the cytosolic fraction, and an increase in the particulate/cytosolic PKC activity ratio.	Tetradecanoylphorbol Acetate	16-19	protein kinase C alpha	Homo sapiens	167-170
11168928-13	2001	PKC activator phorbol 12-myristate 13-acetate (PMA) induced 2.2- and 1.4-fold increase in TGF-beta 1 and FN mRNA expression, respectively.	Tetradecanoylphorbol Acetate	14-45	proline rich transmembrane protein 2	Homo sapiens	0-3
11158244-7	2001	PMA treatment also produced an increase in the phosphorylation of serine 890 on the NR1 subunit, a known PKC site, at 5 min with phosphorylation returning to near basal levels by 10 min while tyrosine phosphorylation of NR2A and NR2B was sustained for up to 15 min.	Tetradecanoylphorbol Acetate	0-3	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	220-224
11160627-4	2001	ERK activation induced by the PKC activator phorbol myristate acetate was inhibited by PTX, PP1, AG1478, and calphostin C.	Tetradecanoylphorbol Acetate	44-69	mitogen-activated protein kinase 1	Homo sapiens	0-3
11160627-4	2001	ERK activation induced by the PKC activator phorbol myristate acetate was inhibited by PTX, PP1, AG1478, and calphostin C.	Tetradecanoylphorbol Acetate	44-69	neuropeptide Y receptor Y4	Homo sapiens	92-95
11152495-4	2001	In U937 cells, overexpression of Cdk9-dn sensitized cells to apoptosis, especially after phorbol myristate acetate (PMA) treatment to induce differentiation to macrophage-like cells.	Tetradecanoylphorbol Acetate	89-114	cyclin dependent kinase 9	Homo sapiens	33-37
11152495-4	2001	In U937 cells, overexpression of Cdk9-dn sensitized cells to apoptosis, especially after phorbol myristate acetate (PMA) treatment to induce differentiation to macrophage-like cells.	Tetradecanoylphorbol Acetate	116-119	cyclin dependent kinase 9	Homo sapiens	33-37
11152495-5	2001	Because Cdk9 function is induced in PMA-treated U937 cells, Cdk9 may play an antiapoptotic role during monocyte differentiation.	Tetradecanoylphorbol Acetate	36-39	cyclin dependent kinase 9	Homo sapiens	8-12
11152495-5	2001	Because Cdk9 function is induced in PMA-treated U937 cells, Cdk9 may play an antiapoptotic role during monocyte differentiation.	Tetradecanoylphorbol Acetate	36-39	cyclin dependent kinase 9	Homo sapiens	60-64
11168928-13	2001	PKC activator phorbol 12-myristate 13-acetate (PMA) induced 2.2- and 1.4-fold increase in TGF-beta 1 and FN mRNA expression, respectively.	Tetradecanoylphorbol Acetate	14-45	transforming growth factor beta 1	Homo sapiens	90-100
11168928-13	2001	PKC activator phorbol 12-myristate 13-acetate (PMA) induced 2.2- and 1.4-fold increase in TGF-beta 1 and FN mRNA expression, respectively.	Tetradecanoylphorbol Acetate	14-45	fibronectin 1	Homo sapiens	105-107
11168928-13	2001	PKC activator phorbol 12-myristate 13-acetate (PMA) induced 2.2- and 1.4-fold increase in TGF-beta 1 and FN mRNA expression, respectively.	Tetradecanoylphorbol Acetate	47-50	proline rich transmembrane protein 2	Homo sapiens	0-3
11168928-13	2001	PKC activator phorbol 12-myristate 13-acetate (PMA) induced 2.2- and 1.4-fold increase in TGF-beta 1 and FN mRNA expression, respectively.	Tetradecanoylphorbol Acetate	47-50	transforming growth factor beta 1	Homo sapiens	90-100
11168928-13	2001	PKC activator phorbol 12-myristate 13-acetate (PMA) induced 2.2- and 1.4-fold increase in TGF-beta 1 and FN mRNA expression, respectively.	Tetradecanoylphorbol Acetate	47-50	fibronectin 1	Homo sapiens	105-107
11168929-7	2001	The effects of mitogens such as phorbol 12-myristate 13-acetate (PMA) and PDGF on the expression of caveolin-1 protein and mRNA were also examined in cultured mesangial cells.	Tetradecanoylphorbol Acetate	32-63	caveolin 1	Rattus norvegicus	100-110
11168928-14	2001	Depletion of PKC and calphostin C, a PKC inhibitor, effectively prevented both PMA and high glucose-induced, but not constitutive, expression of TGF-beta 1 and FN.	Tetradecanoylphorbol Acetate	79-82	proline rich transmembrane protein 2	Homo sapiens	13-16
11168929-7	2001	The effects of mitogens such as phorbol 12-myristate 13-acetate (PMA) and PDGF on the expression of caveolin-1 protein and mRNA were also examined in cultured mesangial cells.	Tetradecanoylphorbol Acetate	65-68	caveolin 1	Rattus norvegicus	100-110
11168928-14	2001	Depletion of PKC and calphostin C, a PKC inhibitor, effectively prevented both PMA and high glucose-induced, but not constitutive, expression of TGF-beta 1 and FN.	Tetradecanoylphorbol Acetate	79-82	proline rich transmembrane protein 2	Homo sapiens	37-40
11168928-14	2001	Depletion of PKC and calphostin C, a PKC inhibitor, effectively prevented both PMA and high glucose-induced, but not constitutive, expression of TGF-beta 1 and FN.	Tetradecanoylphorbol Acetate	79-82	fibronectin 1	Homo sapiens	160-162
11236937-5	2001	In contrast, treatment by TGFbeta1 +/- TPA resulted in an efficient G1/G0 arrest, but did not appear to induce terminal differentiation.	Tetradecanoylphorbol Acetate	39-42	transforming growth factor beta 1	Homo sapiens	26-34
11266445-7	2001	Activation of AIM-1 by the induced expression of AIM-1(wild-type) canceled TPA-induced polyploidization of K562 cells significantly, whereas that of STK15 did not.	Tetradecanoylphorbol Acetate	75-78	crystallin beta-gamma domain containing 1	Homo sapiens	14-19
11160843-5	2001	The intracellular concentration of annexin V increased with the addition of PKC activator (12-O:-tetradecanoylphorbor-13-acetate; TPA) much as it did with the addition of buserelin, and the rise in the concentration caused by the addition of buserelin was completely attenuated by pretreatment with PKC inhibitor (calphostin C).	Tetradecanoylphorbol Acetate	130-133	proline rich transmembrane protein 2	Homo sapiens	76-79
11237479-9	2001	PMA induced both resorption and IL-6 production which were both blocked by indomethacin, indicating a role for PKC in the control of prostaglandin production.	Tetradecanoylphorbol Acetate	0-3	interleukin 6	Mus musculus	32-36
11266445-7	2001	Activation of AIM-1 by the induced expression of AIM-1(wild-type) canceled TPA-induced polyploidization of K562 cells significantly, whereas that of STK15 did not.	Tetradecanoylphorbol Acetate	75-78	crystallin beta-gamma domain containing 1	Homo sapiens	49-54
11050091-8	2001	PMA could also activate a signaling pathway involving MEK1/ERK2/c-Jun-dependent uPA expression.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase	Homo sapiens	80-83
11050091-8	2001	PMA could also activate a signaling pathway involving MEK1/ERK2/c-Jun-dependent uPA expression.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	59-63
11162506-4	2001	In this study, we have addressed the role of the PKC (protein kinase C) signaling pathway in the induction of p21 in response to PMA (phorbol myristate acetate) and okadaic acid.	Tetradecanoylphorbol Acetate	129-132	cyclin dependent kinase inhibitor 1A	Homo sapiens	110-113
11145705-2	2001	In bone marrow (BM) neutrophils isolated from rac2(-/-) mice generated by gene targeting, we previously reported that PMA-induced superoxide production was reduced by about 4-fold, which was partially corrected in TNF-alpha-primed BM neutrophils and in peritoneal exudate neutrophils.	Tetradecanoylphorbol Acetate	118-121	tumor necrosis factor	Mus musculus	214-223
11162506-4	2001	In this study, we have addressed the role of the PKC (protein kinase C) signaling pathway in the induction of p21 in response to PMA (phorbol myristate acetate) and okadaic acid.	Tetradecanoylphorbol Acetate	134-159	cyclin dependent kinase inhibitor 1A	Homo sapiens	110-113
11162506-5	2001	Levels of p21 (protein and mRNA) rapidly increased (within approximately 4 h) in U937 cells treated with PMA.	Tetradecanoylphorbol Acetate	105-108	cyclin dependent kinase inhibitor 1A	Homo sapiens	10-13
11182156-1	2001	The cDNA clone of bovine pim-1 has been isolated from phorbol-12-myristate-13-acetate (PMA) and concanavalin A (ConA)-activated peripheral blood lymphocytes (PBLs).	Tetradecanoylphorbol Acetate	54-85	Pim-1 proto-oncogene, serine/threonine kinase	Bos taurus	25-30
11133494-5	2001	Immunohistochemistry of feline pulmonary arterial smooth muscle cells demonstrated localization of PKC-alpha and -delta isozymes in response to phorbol 12-myristate 13-acetate and angiotensin II.	Tetradecanoylphorbol Acetate	144-175	protein kinase C alpha	Homo sapiens	99-119
11182156-1	2001	The cDNA clone of bovine pim-1 has been isolated from phorbol-12-myristate-13-acetate (PMA) and concanavalin A (ConA)-activated peripheral blood lymphocytes (PBLs).	Tetradecanoylphorbol Acetate	87-90	Pim-1 proto-oncogene, serine/threonine kinase	Bos taurus	25-30
11145836-4	2001	The IL-1H transcripts were stimulated by phorbol ester (PMA) in human cell lines (A431, THP-1 and KG-1) and peripheral blood mononuclear cells (HPBMC) and dendritic cells (NHDC).	Tetradecanoylphorbol Acetate	56-59	GLI family zinc finger 2	Homo sapiens	88-93
11741253-9	2001	The hPepT1-GFP fusion protein was not found in either early endosome or lysosome of Caco-2 cells under normal conditions; however, it was detected in some subsets of lysosomes and early endosomes in phorbol 12-myristate 13-acetate (PMA)-treated Caco-2 cells.	Tetradecanoylphorbol Acetate	199-230	solute carrier family 15 member 1	Homo sapiens	4-10
11741253-9	2001	The hPepT1-GFP fusion protein was not found in either early endosome or lysosome of Caco-2 cells under normal conditions; however, it was detected in some subsets of lysosomes and early endosomes in phorbol 12-myristate 13-acetate (PMA)-treated Caco-2 cells.	Tetradecanoylphorbol Acetate	232-235	solute carrier family 15 member 1	Homo sapiens	4-10
11460474-5	2001	The availability of recombinant fragments that correspond to the alpha C-domain made it possible to further clarify this mechanism and to reveal novel cryptic sites in this domain for plasminogen and its activator tPA, whose exposure may play an important role in the regulation of fibrinolysis.	Tetradecanoylphorbol Acetate	214-217	cripto, FRL-1, cryptic family 1	Homo sapiens	151-158
11460488-0	2001	Fibrinogen alpha C domains contain cryptic plasminogen and tPA binding sites.	Tetradecanoylphorbol Acetate	59-62	fibrinogen beta chain	Homo sapiens	0-10
11460488-1	2001	Surface plasmon resonance and ELISA experiments revealed that recombinant fibrinogen alpha C fragment (residues A alpha 221-610) corresponding to the alpha C domain binds tPA and plasminogen with high affinity.	Tetradecanoylphorbol Acetate	171-174	fibrinogen beta chain	Homo sapiens	74-84
11734063-4	2001	RESULTS: PLD2, but not PLD1, mRNA and protein were detected in these cells and endogenous PLD activity and ACh synthesis were stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	173-176	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	9-12
11133755-5	2001	The results showed that (1) bis-indolylmaleimide I, which blocks protein kinase C (PKC) activation; (2) down-modulation of conventional or novel classes of PKC by phorbol myristate acetate; and (3) ribozymes specific for PKCalpha each inhibited proplatelet formation.	Tetradecanoylphorbol Acetate	163-188	protein kinase C, alpha	Mus musculus	156-159
11734063-9	2001	Overexpression of human PLD1 by transient transfection increased PLD activity by 4.6-fold and ACh synthesis by 2.3-fold in the presence of PMA as compared to controls.	Tetradecanoylphorbol Acetate	139-142	phospholipase D1	Homo sapiens	24-28
11734063-9	2001	Overexpression of human PLD1 by transient transfection increased PLD activity by 4.6-fold and ACh synthesis by 2.3-fold in the presence of PMA as compared to controls.	Tetradecanoylphorbol Acetate	139-142	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	24-27
11112695-4	2001	Release of the 80 kDa soluble E-cadherin fragment is stimulated by phorbol-12-myristate-13-acetate and is inhibited by overexpression of the tissue inhibitor of metalloproteinases-2.	Tetradecanoylphorbol Acetate	67-98	cadherin 1	Homo sapiens	30-40
12064601-7	2001	Treatment with kinase activators, including epidermal growth factor (EGF) and the tumor promoting phorbol ester 12-O-tetradecanylphorbol-13-acetate (TPA), caused a shift in the mobility of the Cx43CT in a manner consistent with the mobility shift observed upon increased phosphorylation of endogenous Cx43.	Tetradecanoylphorbol Acetate	149-152	gap junction protein, alpha 1	Rattus norvegicus	193-197
12064601-7	2001	Treatment with kinase activators, including epidermal growth factor (EGF) and the tumor promoting phorbol ester 12-O-tetradecanylphorbol-13-acetate (TPA), caused a shift in the mobility of the Cx43CT in a manner consistent with the mobility shift observed upon increased phosphorylation of endogenous Cx43.	Tetradecanoylphorbol Acetate	149-152	gap junction protein, alpha 1	Rattus norvegicus	301-305
11134898-5	2001	Superoxide dismutase, catalase, and glutathione/glutathione peroxidase inhibited the PMA-induced increase in intracellular DCFH(2) oxidation.	Tetradecanoylphorbol Acetate	85-88	catalase	Mus musculus	22-30
11367517-4	2001	In the present investigations, we have examined the influence of thalidomide on nuclear levels of NF-kappa B in human peripheral blood mononuclear cells (PBMC) following activation with mitogen or phorbol myristate acetate (PMA)/ionophore.	Tetradecanoylphorbol Acetate	197-222	nuclear factor kappa B subunit 1	Homo sapiens	98-108
11367517-4	2001	In the present investigations, we have examined the influence of thalidomide on nuclear levels of NF-kappa B in human peripheral blood mononuclear cells (PBMC) following activation with mitogen or phorbol myristate acetate (PMA)/ionophore.	Tetradecanoylphorbol Acetate	224-227	nuclear factor kappa B subunit 1	Homo sapiens	98-108
11115551-6	2001	As an initial step, we determined whether lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA) modulate iNOS protein expression in RIE-1 cells.	Tetradecanoylphorbol Acetate	71-102	nitric oxide synthase 2	Rattus norvegicus	118-122
11115551-6	2001	As an initial step, we determined whether lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA) modulate iNOS protein expression in RIE-1 cells.	Tetradecanoylphorbol Acetate	104-107	nitric oxide synthase 2	Rattus norvegicus	118-122
11115551-8	2001	The induction of iNOS by the treatment with LPS/PMA was concentration- and time-dependent.	Tetradecanoylphorbol Acetate	48-51	nitric oxide synthase 2	Rattus norvegicus	17-21
11115551-10	2001	Pretreatment with specific PKC inhibitors, bisindolylmaleimide I or Go 6976, inhibited LPS/PMA, LPS/DAG, or LPS/DC-induced iNOS expression and activity.	Tetradecanoylphorbol Acetate	91-94	nitric oxide synthase 2	Rattus norvegicus	123-127
11115551-11	2001	Extracts of the cells treated with LPS/PMA, LPS/DAG or LPS/DC had a high iNOS activity compared to that of control (p&lt;0.04 to p&lt;0.0001).	Tetradecanoylphorbol Acetate	39-42	nitric oxide synthase 2	Rattus norvegicus	73-77
11419696-3	2001	The PLD activation induced by BK was blocked by pretreatment of A-431 cells with staurosporine, or by prolonged treatment with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	127-158	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-7
11419696-3	2001	The PLD activation induced by BK was blocked by pretreatment of A-431 cells with staurosporine, or by prolonged treatment with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	127-158	kininogen 1	Homo sapiens	30-32
11419696-3	2001	The PLD activation induced by BK was blocked by pretreatment of A-431 cells with staurosporine, or by prolonged treatment with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	160-163	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-7
11419696-3	2001	The PLD activation induced by BK was blocked by pretreatment of A-431 cells with staurosporine, or by prolonged treatment with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	160-163	kininogen 1	Homo sapiens	30-32
11436205-4	2001	To demonstrate that the comparative kinetic RT/PCR strategy-which uses a housekeeping gene as internal standard-is a quantitative method to detect significant differences in mRNA levels between different samples, the inhibitory effect of heparin on phorbol 12-myristate 13-acetate (PMA)-induced-TGF-beta1 mRNA expression was evaluated by RT/PCR and RPA, the standard method of mRNA quantification, and the results were compared.	Tetradecanoylphorbol Acetate	249-280	transforming growth factor beta 1	Homo sapiens	295-304
12539551-4	2001	The expression of IL-4 and IL-5 mRNA and protein of asthmatic T lymphocytes stimulated with PMA was significantly higher than that of asthmatic T lymphocytes stimulated without PMA respectively (P &lt; 0.01) and that of normal T lymphocytes stimulated with PMA respectively (P &lt; 0.01).	Tetradecanoylphorbol Acetate	92-95	interleukin 4	Homo sapiens	18-22
11220710-6	2001	Estimates of adiposity, insulin, and triglycerides were correlated with PAI-1 and tPA-Ag.	Tetradecanoylphorbol Acetate	82-85	insulin	Homo sapiens	24-31
11384880-11	2001	Furthermore, we showed that the PKC activator phorbol-12-myristate-13-acetate (PMA) also potentiated the IL-4-induced 3beta-HSD activity, thus suggesting that one signaling molecule that is involved in the signal transduction of the IL-4 action on 3beta-HSD type 1 expression is also a substrate for PKC.	Tetradecanoylphorbol Acetate	46-77	interleukin 4	Homo sapiens	105-109
11384880-11	2001	Furthermore, we showed that the PKC activator phorbol-12-myristate-13-acetate (PMA) also potentiated the IL-4-induced 3beta-HSD activity, thus suggesting that one signaling molecule that is involved in the signal transduction of the IL-4 action on 3beta-HSD type 1 expression is also a substrate for PKC.	Tetradecanoylphorbol Acetate	46-77	interleukin 4	Homo sapiens	233-237
11384880-11	2001	Furthermore, we showed that the PKC activator phorbol-12-myristate-13-acetate (PMA) also potentiated the IL-4-induced 3beta-HSD activity, thus suggesting that one signaling molecule that is involved in the signal transduction of the IL-4 action on 3beta-HSD type 1 expression is also a substrate for PKC.	Tetradecanoylphorbol Acetate	79-82	interleukin 4	Homo sapiens	105-109
11384880-11	2001	Furthermore, we showed that the PKC activator phorbol-12-myristate-13-acetate (PMA) also potentiated the IL-4-induced 3beta-HSD activity, thus suggesting that one signaling molecule that is involved in the signal transduction of the IL-4 action on 3beta-HSD type 1 expression is also a substrate for PKC.	Tetradecanoylphorbol Acetate	79-82	interleukin 4	Homo sapiens	233-237
11746514-3	2001	Midazolam inhibited the accumulation of HSP27 induced by vasopressin or 12-O-tetradecanoylphorbol 13-acetate (TPA), a direct activator of protein kinase C. Midazolam also reduced the vasopressin-induced level of the mRNA for HSP27.	Tetradecanoylphorbol Acetate	72-108	arginine vasopressin	Homo sapiens	183-194
11746514-3	2001	Midazolam inhibited the accumulation of HSP27 induced by vasopressin or 12-O-tetradecanoylphorbol 13-acetate (TPA), a direct activator of protein kinase C. Midazolam also reduced the vasopressin-induced level of the mRNA for HSP27.	Tetradecanoylphorbol Acetate	110-113	arginine vasopressin	Homo sapiens	183-194
12539551-4	2001	The expression of IL-4 and IL-5 mRNA and protein of asthmatic T lymphocytes stimulated with PMA was significantly higher than that of asthmatic T lymphocytes stimulated without PMA respectively (P &lt; 0.01) and that of normal T lymphocytes stimulated with PMA respectively (P &lt; 0.01).	Tetradecanoylphorbol Acetate	177-180	interleukin 4	Homo sapiens	18-22
12539551-4	2001	The expression of IL-4 and IL-5 mRNA and protein of asthmatic T lymphocytes stimulated with PMA was significantly higher than that of asthmatic T lymphocytes stimulated without PMA respectively (P &lt; 0.01) and that of normal T lymphocytes stimulated with PMA respectively (P &lt; 0.01).	Tetradecanoylphorbol Acetate	177-180	interleukin 4	Homo sapiens	18-22
12539551-5	2001	The expression of IL-4 and IL-5 mRNA and protein of asthmatic T lymphocytes stimulated with PMA and Ro31-8220 was significantly lower than that of asthmatic T lymphocytes stimulated only with PMA respectively (P &lt; 0.01).	Tetradecanoylphorbol Acetate	92-95	interleukin 4	Homo sapiens	18-22
11516830-6	2001	In contrast, the protein kinase C activator phorbol 12-myristate 13-acetate decreased both apolipoprotein E secretion (to 59% at 48 h) and mRNA expression (to 22% at 1 h).	Tetradecanoylphorbol Acetate	44-75	apolipoprotein E	Rattus norvegicus	91-107
11216860-5	2001	Using two different cell lines, SK-HEP-1 and Hep 3B cells, we have studied effects of phorbol 12-myristate 13-acetate (PMA) on TSP-1 expression.	Tetradecanoylphorbol Acetate	86-117	thrombospondin 1	Homo sapiens	127-132
11216860-5	2001	Using two different cell lines, SK-HEP-1 and Hep 3B cells, we have studied effects of phorbol 12-myristate 13-acetate (PMA) on TSP-1 expression.	Tetradecanoylphorbol Acetate	119-122	thrombospondin 1	Homo sapiens	127-132
11216860-6	2001	TSP-1 synthesis was stimulated by PMA in both cell lines.	Tetradecanoylphorbol Acetate	34-37	thrombospondin 1	Homo sapiens	0-5
11216860-7	2001	When the cells were treated with PMA, the TSP-1 mRNA started to increase at 30 min and reached the maximal level at 6 h. TSP-1 induction by PMA was completely inhibited by the pre-treatment of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a potent protein kinase C inhibitor.	Tetradecanoylphorbol Acetate	33-36	thrombospondin 1	Homo sapiens	42-47
11216860-7	2001	When the cells were treated with PMA, the TSP-1 mRNA started to increase at 30 min and reached the maximal level at 6 h. TSP-1 induction by PMA was completely inhibited by the pre-treatment of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a potent protein kinase C inhibitor.	Tetradecanoylphorbol Acetate	33-36	thrombospondin 1	Homo sapiens	121-126
11216860-7	2001	When the cells were treated with PMA, the TSP-1 mRNA started to increase at 30 min and reached the maximal level at 6 h. TSP-1 induction by PMA was completely inhibited by the pre-treatment of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a potent protein kinase C inhibitor.	Tetradecanoylphorbol Acetate	140-143	thrombospondin 1	Homo sapiens	42-47
11216860-7	2001	When the cells were treated with PMA, the TSP-1 mRNA started to increase at 30 min and reached the maximal level at 6 h. TSP-1 induction by PMA was completely inhibited by the pre-treatment of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a potent protein kinase C inhibitor.	Tetradecanoylphorbol Acetate	140-143	thrombospondin 1	Homo sapiens	121-126
11516830-7	2001	Phorbol 12-myristate 13-acetate also reversed the effects of dibutyryl-cAMP.	Tetradecanoylphorbol Acetate	0-31	cathelicidin antimicrobial peptide	Rattus norvegicus	71-75
11108799-5	2000	The observations that a selective activator of protein kinase C (PKC)-alpha (sapintoxin D) mimics the PMA effect, whereas a selective PKC-alpha inhibitor (Ro-320432) antagonizes this effect, suggest a regulatory role of PKC-alpha in the LPS signaling pathway in mouse BMC.	Tetradecanoylphorbol Acetate	102-105	protein kinase C, alpha	Mus musculus	65-75
11292237-4	2001	The production of hsp72 was induced by heat, PMA, H2O2 and SNP.	Tetradecanoylphorbol Acetate	45-48	heat shock protein family A (Hsp70) member 1A	Homo sapiens	18-23
12053198-0	2001	Differentially Expressed Gene Profiles of hCR2-transfected Mouse Cells before and after EBV Infection and TPA Treatment.	Tetradecanoylphorbol Acetate	106-109	complement C3d receptor 2	Homo sapiens	42-46
12053198-2	2001	Results indicated that differentially expressed gene prifiles of EBV and TPA treated, hCR2-transfected mouse cells was preliminarily established.	Tetradecanoylphorbol Acetate	73-76	complement C3d receptor 2	Homo sapiens	86-90
11042219-1	2000	Treatment of human U-937 myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with protein kinase C (PKC) betaII-mediated activation of the stress-activated protein kinase (SAPK) pathway.	Tetradecanoylphorbol Acetate	53-89	mitogen-activated protein kinase 9	Homo sapiens	172-203
11042219-1	2000	Treatment of human U-937 myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with protein kinase C (PKC) betaII-mediated activation of the stress-activated protein kinase (SAPK) pathway.	Tetradecanoylphorbol Acetate	53-89	mitogen-activated protein kinase 9	Homo sapiens	205-209
11042219-1	2000	Treatment of human U-937 myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with protein kinase C (PKC) betaII-mediated activation of the stress-activated protein kinase (SAPK) pathway.	Tetradecanoylphorbol Acetate	91-94	mitogen-activated protein kinase 9	Homo sapiens	172-203
11042219-1	2000	Treatment of human U-937 myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with protein kinase C (PKC) betaII-mediated activation of the stress-activated protein kinase (SAPK) pathway.	Tetradecanoylphorbol Acetate	91-94	mitogen-activated protein kinase 9	Homo sapiens	205-209
11042219-5	2000	The results also demonstrate that TPA-induced ROS production is required for activation of the MEK kinase-1 (MEKK-1)--&gt; SAPK pathway.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 9	Homo sapiens	123-127
11060282-3	2000	From a cDNA library of phorbol 12-myristate 13-acetate-stimulated THP-1 cells, we isolated a cDNA encoding a novel protein designated SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), which acts as a receptor for OxLDL.	Tetradecanoylphorbol Acetate	23-54	C-X-C motif chemokine ligand 16	Homo sapiens	134-141
11060282-3	2000	From a cDNA library of phorbol 12-myristate 13-acetate-stimulated THP-1 cells, we isolated a cDNA encoding a novel protein designated SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), which acts as a receptor for OxLDL.	Tetradecanoylphorbol Acetate	23-54	C-X-C motif chemokine ligand 16	Homo sapiens	143-216
11013244-8	2000	Importantly, HAI-1 and the HGFA.HAI-1 complex were quickly released from the cell surface by treatment with phorbol 12-myristate 13-acetate or interleukin 1beta accompanying the generation of 58-kDa fragments of HAI-1, which are less potent against HGFA, as well as significant recovery of HGFA activity in the culture supernatant.	Tetradecanoylphorbol Acetate	108-139	hepatocyte growth factor activator	Cricetulus griseus	27-31
11013244-8	2000	Importantly, HAI-1 and the HGFA.HAI-1 complex were quickly released from the cell surface by treatment with phorbol 12-myristate 13-acetate or interleukin 1beta accompanying the generation of 58-kDa fragments of HAI-1, which are less potent against HGFA, as well as significant recovery of HGFA activity in the culture supernatant.	Tetradecanoylphorbol Acetate	108-139	hepatocyte growth factor activator	Cricetulus griseus	249-253
11013244-8	2000	Importantly, HAI-1 and the HGFA.HAI-1 complex were quickly released from the cell surface by treatment with phorbol 12-myristate 13-acetate or interleukin 1beta accompanying the generation of 58-kDa fragments of HAI-1, which are less potent against HGFA, as well as significant recovery of HGFA activity in the culture supernatant.	Tetradecanoylphorbol Acetate	108-139	hepatocyte growth factor activator	Cricetulus griseus	249-253
11172467-6	2001	In addition, the phorbol myristate acetate (PMA)-stimulated or PMA-nonstimulated 22-kd a-subunit (p22phox) mRNA levels and 47-kd a-subunit (p47phox) protein levels in NADPH oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	17-42	peroxisome proliferator activated receptor gamma	Homo sapiens	228-237
11172467-6	2001	In addition, the phorbol myristate acetate (PMA)-stimulated or PMA-nonstimulated 22-kd a-subunit (p22phox) mRNA levels and 47-kd a-subunit (p47phox) protein levels in NADPH oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	44-47	peroxisome proliferator activated receptor gamma	Homo sapiens	228-237
11172467-6	2001	In addition, the phorbol myristate acetate (PMA)-stimulated or PMA-nonstimulated 22-kd a-subunit (p22phox) mRNA levels and 47-kd a-subunit (p47phox) protein levels in NADPH oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	63-66	peroxisome proliferator activated receptor gamma	Homo sapiens	228-237
11123898-0	2000	Conversion of fibrinogen to fibrin: mechanism of exposure of tPA- and plasminogen-binding sites.	Tetradecanoylphorbol Acetate	61-64	fibrinogen beta chain	Homo sapiens	14-24
11104682-5	2000	In view of the slower kinetics of PMA-induced RGS16 expression and the tight correlation between TNFalpha and RGS16 mRNA induction among the cell lines studied, we suggest that activation of PKC up-regulates RGS16 via TNFalpha.	Tetradecanoylphorbol Acetate	34-37	proline rich transmembrane protein 2	Homo sapiens	191-194
11104682-5	2000	In view of the slower kinetics of PMA-induced RGS16 expression and the tight correlation between TNFalpha and RGS16 mRNA induction among the cell lines studied, we suggest that activation of PKC up-regulates RGS16 via TNFalpha.	Tetradecanoylphorbol Acetate	34-37	tumor necrosis factor	Homo sapiens	218-226
11113454-5	2000	Activation of PKC by both TeTx and TPA results in a loss of transport capacity and serotonin transporter (SERT) phosphorylation, which are abolished by coapplication of the specific PKC inhibitor bisindolylmaleimide-1.	Tetradecanoylphorbol Acetate	35-38	solute carrier family 6 member 4	Rattus norvegicus	83-104
10993886-6	2000	Interestingly, low salicylate concentrations (&lt;/=250 microm) inhibit p70(s6k) activation by phorbol myristate acetate, while higher salicylate concentrations (&gt;/=5 mm) are required to block p70(s6k) activation by epidermal growth factor + insulin-like growth factor-1.	Tetradecanoylphorbol Acetate	95-120	ubiquitin associated and SH3 domain containing B	Homo sapiens	72-75
11113454-5	2000	Activation of PKC by both TeTx and TPA results in a loss of transport capacity and serotonin transporter (SERT) phosphorylation, which are abolished by coapplication of the specific PKC inhibitor bisindolylmaleimide-1.	Tetradecanoylphorbol Acetate	35-38	solute carrier family 6 member 4	Rattus norvegicus	106-110
11078714-4	2000	Depletion of cellular PKC by overnight treatment with phorbol 12-myristate 13-acetate (PMA) similarly augmented ANG II-induced IP production.	Tetradecanoylphorbol Acetate	54-85	angiotensinogen	Rattus norvegicus	112-118
11087819-6	2000	It was demonstrated that anagen was successfully induced in Stat3-disrupted as well as wild-type mice by chemical or mechanical stimulation, i.e. , by topical application of phorbol 12-myristate 13-acetate (PMA) or by hair plucking, respectively.	Tetradecanoylphorbol Acetate	174-205	signal transducer and activator of transcription 3	Mus musculus	60-65
11087819-6	2000	It was demonstrated that anagen was successfully induced in Stat3-disrupted as well as wild-type mice by chemical or mechanical stimulation, i.e. , by topical application of phorbol 12-myristate 13-acetate (PMA) or by hair plucking, respectively.	Tetradecanoylphorbol Acetate	207-210	signal transducer and activator of transcription 3	Mus musculus	60-65
11603297-7	2000	However, at higher stimulation with LPS 100 mg/L and PMA 200 nmol/L, they downregulated TNF alpha production.	Tetradecanoylphorbol Acetate	53-56	tumor necrosis factor	Homo sapiens	88-97
11603298-9	2000	FI0-c 4 mg/L downregulated high-dose LPS- and PMA-induced IL-1 alpha or TNF alpha mRNA and their protein production by THP-1 cells.	Tetradecanoylphorbol Acetate	46-49	tumor necrosis factor	Homo sapiens	72-81
11152962-3	2000	In agreement with our previous finding that p90(rsk1) is essential for TPA-induced activation of NF-kappaB in Adenovirus 5E1-transformed Baby Rat Kidney cells, we now report that the MEK/ERK/p90(rsk1) inhibitor U0126 efficiently blocks TPA-induced IkappaBalpha processing in these cells.	Tetradecanoylphorbol Acetate	71-74	Eph receptor B1	Rattus norvegicus	187-190
11118039-2	2000	We investigated the role of NEP in PC cell susceptibility to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	61-97	membrane metalloendopeptidase	Homo sapiens	28-31
11118039-3	2000	Western analysis showed that expression of NEP and protein kinase Cdelta (PKCdelta) correlated with PC cell sensitivity to TPA-induced growth arrest and apoptosis in LNCaP cells and in TSU-Prl cells expressing an inducible wild-type NEP protein.	Tetradecanoylphorbol Acetate	123-126	membrane metalloendopeptidase	Homo sapiens	43-46
11118039-3	2000	Western analysis showed that expression of NEP and protein kinase Cdelta (PKCdelta) correlated with PC cell sensitivity to TPA-induced growth arrest and apoptosis in LNCaP cells and in TSU-Prl cells expressing an inducible wild-type NEP protein.	Tetradecanoylphorbol Acetate	123-126	membrane metalloendopeptidase	Homo sapiens	233-236
11118039-4	2000	Inhibition of NEP enzyme activity using the specific NEP inhibitor CGS24592, or inhibition of PKCdelta using Rottlerin at concentrations that inhibit PKCdelta but not PKCalpha, significantly inhibited TPA-induced growth inhibition and cell death.	Tetradecanoylphorbol Acetate	201-204	membrane metalloendopeptidase	Homo sapiens	14-17
11118039-7	2000	These results indicate that expression of enzymatically active NEP by PC cells is necessary for TPA-induced apoptosis, and that NEP inhibits neuropeptide-induced, cSrc-mediated PKCdelta degradation.	Tetradecanoylphorbol Acetate	96-99	membrane metalloendopeptidase	Homo sapiens	63-66
11200811-3	2000	METHOD OF STUDY: Phytohemaglutinin (PHA) or phorbol myristate acetate (PMA) activated T cell adhesion to the following extracellular matrix proteins: collagen IV, fibronectin and elastin were studied in women with the history of RSA.	Tetradecanoylphorbol Acetate	44-69	fibronectin 1	Homo sapiens	163-174
11200811-3	2000	METHOD OF STUDY: Phytohemaglutinin (PHA) or phorbol myristate acetate (PMA) activated T cell adhesion to the following extracellular matrix proteins: collagen IV, fibronectin and elastin were studied in women with the history of RSA.	Tetradecanoylphorbol Acetate	71-74	fibronectin 1	Homo sapiens	163-174
11145168-1	2000	Interaction between a tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA), and ligands of nuclear receptors has been interpreted as the result of crosstalk between the nuclear receptors and oncogenic transcription factor AP-1.	Tetradecanoylphorbol Acetate	38-74	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	228-232
11145168-1	2000	Interaction between a tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA), and ligands of nuclear receptors has been interpreted as the result of crosstalk between the nuclear receptors and oncogenic transcription factor AP-1.	Tetradecanoylphorbol Acetate	76-79	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	228-232
11175257-2	2000	We show here that activation of the conventional and novel isoforms of PKC with 12-O-tetradecanoyl phorbol-13- ester (TPA) induces apoptosis in salivary acinar cells as indicated by DNA fragmentation and activation of caspase-3.	Tetradecanoylphorbol Acetate	118-121	protein kinase C alpha	Homo sapiens	71-74
11175257-2	2000	We show here that activation of the conventional and novel isoforms of PKC with 12-O-tetradecanoyl phorbol-13- ester (TPA) induces apoptosis in salivary acinar cells as indicated by DNA fragmentation and activation of caspase-3.	Tetradecanoylphorbol Acetate	118-121	caspase 3	Homo sapiens	218-227
11152962-3	2000	In agreement with our previous finding that p90(rsk1) is essential for TPA-induced activation of NF-kappaB in Adenovirus 5E1-transformed Baby Rat Kidney cells, we now report that the MEK/ERK/p90(rsk1) inhibitor U0126 efficiently blocks TPA-induced IkappaBalpha processing in these cells.	Tetradecanoylphorbol Acetate	236-239	Eph receptor B1	Rattus norvegicus	187-190
11175257-4	2000	Analysis of PKC isoform expression by immunoblot shows that TPA-induced downregulation of PKC alpha and PKC delta is delayed in cells pre-treated with calpeptin, and that this correlates with an increase of these isoforms in the membrane fraction of cells.	Tetradecanoylphorbol Acetate	60-63	protein kinase C alpha	Homo sapiens	90-99
11175257-6	2000	Expression of constitutively activated PKC alpha or PKC delta, but not kinase negative mutants of these isoforms, or constitutively activated PKC epsilon, induces apoptosis in salivary acinar cells, suggesting a role for these isoforms in TPA-induced apoptosis.	Tetradecanoylphorbol Acetate	239-242	protein kinase C alpha	Homo sapiens	39-48
11152962-5	2000	Activation of the IKK complex in response to TPA is mediated by PKC-alpha, since both the PKC inhibitor GF109203 and a catalytically inactive PKC-alpha mutant inhibit activation of endogenous IKK by TPA, but not by tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	45-48	protein kinase C alpha	Homo sapiens	64-73
11152962-5	2000	Activation of the IKK complex in response to TPA is mediated by PKC-alpha, since both the PKC inhibitor GF109203 and a catalytically inactive PKC-alpha mutant inhibit activation of endogenous IKK by TPA, but not by tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	45-48	protein kinase C alpha	Homo sapiens	64-67
11152962-5	2000	Activation of the IKK complex in response to TPA is mediated by PKC-alpha, since both the PKC inhibitor GF109203 and a catalytically inactive PKC-alpha mutant inhibit activation of endogenous IKK by TPA, but not by tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	45-48	protein kinase C alpha	Homo sapiens	142-151
11152962-5	2000	Activation of the IKK complex in response to TPA is mediated by PKC-alpha, since both the PKC inhibitor GF109203 and a catalytically inactive PKC-alpha mutant inhibit activation of endogenous IKK by TPA, but not by tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	45-48	tumor necrosis factor	Homo sapiens	215-242
11152962-5	2000	Activation of the IKK complex in response to TPA is mediated by PKC-alpha, since both the PKC inhibitor GF109203 and a catalytically inactive PKC-alpha mutant inhibit activation of endogenous IKK by TPA, but not by tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	45-48	tumor necrosis factor	Homo sapiens	244-253
11152962-5	2000	Activation of the IKK complex in response to TPA is mediated by PKC-alpha, since both the PKC inhibitor GF109203 and a catalytically inactive PKC-alpha mutant inhibit activation of endogenous IKK by TPA, but not by tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	199-202	protein kinase C alpha	Homo sapiens	64-73
11152962-5	2000	Activation of the IKK complex in response to TPA is mediated by PKC-alpha, since both the PKC inhibitor GF109203 and a catalytically inactive PKC-alpha mutant inhibit activation of endogenous IKK by TPA, but not by tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	199-202	protein kinase C alpha	Homo sapiens	64-67
11152962-5	2000	Activation of the IKK complex in response to TPA is mediated by PKC-alpha, since both the PKC inhibitor GF109203 and a catalytically inactive PKC-alpha mutant inhibit activation of endogenous IKK by TPA, but not by tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	199-202	protein kinase C alpha	Homo sapiens	142-151
11152962-5	2000	Activation of the IKK complex in response to TPA is mediated by PKC-alpha, since both the PKC inhibitor GF109203 and a catalytically inactive PKC-alpha mutant inhibit activation of endogenous IKK by TPA, but not by tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	199-202	tumor necrosis factor	Homo sapiens	215-242
11152962-5	2000	Activation of the IKK complex in response to TPA is mediated by PKC-alpha, since both the PKC inhibitor GF109203 and a catalytically inactive PKC-alpha mutant inhibit activation of endogenous IKK by TPA, but not by tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	199-202	tumor necrosis factor	Homo sapiens	244-253
11097748-6	2000	Actinomycin D lowered TNF-alpha mRNA in a similar way as PD98059 but was less inhibitory on PMA- or anisomycin-induced formation of TNF-alpha, thus confirming that these agents acted by causing translational derepression.	Tetradecanoylphorbol Acetate	92-95	tumor necrosis factor	Homo sapiens	132-141
11108241-11	2000	We conclude that TACE is an enzyme required for PMA-induced GHBP shedding and that PMA-induced down-regulation of GHR abundance may in significant measure be attributable to TACE-mediated GHR proteolysis.	Tetradecanoylphorbol Acetate	48-51	disintegrin and metalloproteinase domain-containing protein 17	Oryctolagus cuniculus	17-21
11125308-3	2000	Concanavalin A or phorbol myristate acetate/calcium ionophore/anti-CD3 stimulation of spleen cells from H2(b) congenic mice induced less IL-1, IL-2, IFN-gamma and MIF mRNA and/or protein than the equivalent cells from H2(d) mice.	Tetradecanoylphorbol Acetate	18-43	interferon gamma	Mus musculus	149-158
11108278-5	2000	High levels of glucose (i.e. 25 mM) and phorbol 12-myristate 13-acetate (PMA; 10(-7) M) increased the secretion of IR-rANG and cellular ANG messenger RNA as well as phosphorylation of p38 MAPK in IRPTCs.	Tetradecanoylphorbol Acetate	40-71	angiotensinogen	Rattus norvegicus	119-122
11108278-5	2000	High levels of glucose (i.e. 25 mM) and phorbol 12-myristate 13-acetate (PMA; 10(-7) M) increased the secretion of IR-rANG and cellular ANG messenger RNA as well as phosphorylation of p38 MAPK in IRPTCs.	Tetradecanoylphorbol Acetate	73-76	angiotensinogen	Rattus norvegicus	119-122
11125308-4	2000	However, following stimulation with lipopolysaccharide or phorbol myristate acetate/calcium ionophore, peritoneal cells from H2(b) mice synthesised significantly more IL-1 beta, TNF-alpha, TNFR and IFN-gamma protein and IFN-gamma mRNA than cells from congenic H2(k) or H2(d) mice.	Tetradecanoylphorbol Acetate	58-83	interleukin 1 beta	Mus musculus	167-176
11125308-4	2000	However, following stimulation with lipopolysaccharide or phorbol myristate acetate/calcium ionophore, peritoneal cells from H2(b) mice synthesised significantly more IL-1 beta, TNF-alpha, TNFR and IFN-gamma protein and IFN-gamma mRNA than cells from congenic H2(k) or H2(d) mice.	Tetradecanoylphorbol Acetate	58-83	tumor necrosis factor	Mus musculus	178-187
11125308-4	2000	However, following stimulation with lipopolysaccharide or phorbol myristate acetate/calcium ionophore, peritoneal cells from H2(b) mice synthesised significantly more IL-1 beta, TNF-alpha, TNFR and IFN-gamma protein and IFN-gamma mRNA than cells from congenic H2(k) or H2(d) mice.	Tetradecanoylphorbol Acetate	58-83	interferon gamma	Mus musculus	198-207
11125308-4	2000	However, following stimulation with lipopolysaccharide or phorbol myristate acetate/calcium ionophore, peritoneal cells from H2(b) mice synthesised significantly more IL-1 beta, TNF-alpha, TNFR and IFN-gamma protein and IFN-gamma mRNA than cells from congenic H2(k) or H2(d) mice.	Tetradecanoylphorbol Acetate	58-83	interferon gamma	Mus musculus	220-229
11125308-3	2000	Concanavalin A or phorbol myristate acetate/calcium ionophore/anti-CD3 stimulation of spleen cells from H2(b) congenic mice induced less IL-1, IL-2, IFN-gamma and MIF mRNA and/or protein than the equivalent cells from H2(d) mice.	Tetradecanoylphorbol Acetate	18-43	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	163-166
11102964-6	2000	A pharmacological study using a specific PKC activator, phorbol-12-myristate-13-acetate, and a protein kinase C (PKC) inhibitor, bisindolylmaleimide, showed that PKC activation is required in order to release uPA from ceramide-stimulated microglia as well as from nonstimulated microglia.	Tetradecanoylphorbol Acetate	56-87	plasminogen activator, urokinase	Homo sapiens	209-212
11029286-2	2000	In HCO(3)(-)-free media, activation of PKC via 12-O-tetradecanoylphorbol 13-acetate (TPA) depolarized apical membrane potential (V(a)) and decreased fractional apical voltage ratio (F(R)).	Tetradecanoylphorbol Acetate	47-83	plasminogen activator, tissue type	Homo sapiens	85-88
11197217-3	2000	Either induced expression of Bfl-1 with 12-o-tetradecanoyl phorbol-13-acetate or exogenous expression of Bfl-1 by transfection in Reh cells promoted cell survival.	Tetradecanoylphorbol Acetate	40-77	BCL2 related protein A1	Homo sapiens	29-34
11082462-8	2000	Cellular iNOS activity did not increase until 6 h after PMA administration.	Tetradecanoylphorbol Acetate	56-59	nitric oxide synthase 2	Rattus norvegicus	9-13
10976111-3	2000	The effect of TPA was specifically abolished by the PKC inhibitor GF109203X and by dominant negative PKCtheta, PKCepsilon, and PKCalpha, suggesting that novel and conventional PKC isoforms mediate phorbol ester action.	Tetradecanoylphorbol Acetate	14-17	protein kinase C alpha	Homo sapiens	52-55
10976111-3	2000	The effect of TPA was specifically abolished by the PKC inhibitor GF109203X and by dominant negative PKCtheta, PKCepsilon, and PKCalpha, suggesting that novel and conventional PKC isoforms mediate phorbol ester action.	Tetradecanoylphorbol Acetate	14-17	protein kinase C alpha	Homo sapiens	127-135
10976111-3	2000	The effect of TPA was specifically abolished by the PKC inhibitor GF109203X and by dominant negative PKCtheta, PKCepsilon, and PKCalpha, suggesting that novel and conventional PKC isoforms mediate phorbol ester action.	Tetradecanoylphorbol Acetate	14-17	protein kinase C alpha	Homo sapiens	101-104
11080259-11	2000	Direct activation of protein kinase C (PKC) by phorbol-12-myristate-13-acetate or 1-oleoyl-2-acetyl-sn-glycerol also stimulated divalent cation entry, without evoking the release of Ca2+ from intracellular stores.	Tetradecanoylphorbol Acetate	47-78	proline rich transmembrane protein 2	Homo sapiens	21-37
11080259-11	2000	Direct activation of protein kinase C (PKC) by phorbol-12-myristate-13-acetate or 1-oleoyl-2-acetyl-sn-glycerol also stimulated divalent cation entry, without evoking the release of Ca2+ from intracellular stores.	Tetradecanoylphorbol Acetate	47-78	proline rich transmembrane protein 2	Homo sapiens	39-42
11121152-4	2000	Electrophoretic mobility shift assays showed that low levels of NF-kappa B binding activity could be induced by phorbol myristate acetate in both normal and atopic dermatitis keratinocytes.	Tetradecanoylphorbol Acetate	112-137	nuclear factor kappa B subunit 1	Homo sapiens	64-74
11121152-6	2000	Atopic dermatitis keratinocyte nuclear lysates had higher constitutive levels of c-Jun, and phorbol myristate acetate promoted an earlier and stronger expression of c-Jun, JunB, and of the phosphorylated forms of c-Fos.	Tetradecanoylphorbol Acetate	92-117	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-176
11192933-1	2000	We previously showed that primary cultures of mTAL cells express cyclooxygenase 2 (COX-2) when challenged with tumor necrosis factor alpha (TNFalpha) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	153-178	prostaglandin-endoperoxide synthase 2	Homo sapiens	65-81
11192933-1	2000	We previously showed that primary cultures of mTAL cells express cyclooxygenase 2 (COX-2) when challenged with tumor necrosis factor alpha (TNFalpha) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	153-178	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-88
11426620-4	2000	However, we show here that cytosine beta-D-arabinofuranoside (Ara C) and 12-O-tetradecanoylphorbol 13-acetate (TPA), agents that activated the MDR1 gene in the H9 T-cell leukemia line, caused different effects on PKC.	Tetradecanoylphorbol Acetate	73-109	ATP binding cassette subfamily B member 1	Homo sapiens	143-147
11426620-4	2000	However, we show here that cytosine beta-D-arabinofuranoside (Ara C) and 12-O-tetradecanoylphorbol 13-acetate (TPA), agents that activated the MDR1 gene in the H9 T-cell leukemia line, caused different effects on PKC.	Tetradecanoylphorbol Acetate	111-114	ATP binding cassette subfamily B member 1	Homo sapiens	143-147
11426620-6	2000	Furthermore, cell permeable ceramide, a lipid messenger known to mediate cellular effects of chemotherapeutic drugs and TPA, activated the MDR1 gene and down-regulated PKC.	Tetradecanoylphorbol Acetate	120-123	ATP binding cassette subfamily B member 1	Homo sapiens	139-143
11093788-5	2000	TPA, a PKC activator, stimulated ICAM-1 expression as well, this effect being inhibited by tyrosine kinase inhibitors.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	7-10
11093788-10	2000	Dominant-negative PKCalpha, NIK, or IKK2, but not IKK1 mutant, inhibited IL-1beta- or TPA-induced ICAM-1 promoter activity.	Tetradecanoylphorbol Acetate	86-89	protein kinase C alpha	Homo sapiens	18-26
10970902-5	2000	The NF-kappaB binding site from the mouse TERT promoter activated transcription when fused to a basal SV40 promoter and enhanced the activity of the native TERT promoter in mouse hepatoma cells stimulated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	210-241	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	4-13
11063592-3	2000	We now report that stimulation of PMN with proinflammatory agonist N-formyl peptides (FMLP), calcium ionophore A(23187), or phorbol mirystate acetate (PMA) is followed by marked downregulation of LXA(4) binding (B(max) decrease of approximately 45%) and decreased activation of phospholipases A(2) (PLA(2)) and D (PLD).	Tetradecanoylphorbol Acetate	151-154	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	314-317
11054378-6	2000	RESULTS: NF-kappaB/Rel activity induced by tumor necrosis factor alpha, 12-O-tetradecanoylphorbol-13-acetate, or overexpression of NF-kappaB-inducing kinase, IKK-alpha, IKK-beta, or constitutively active IKK-alpha and IKK-beta mutants was inhibited dose dependently by sulfasalazine.	Tetradecanoylphorbol Acetate	72-108	nuclear factor kappa B subunit 1	Homo sapiens	9-18
11053033-3	2000	Triptolide, with an IC(50) of approximately 20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha, or IL-1 beta.	Tetradecanoylphorbol Acetate	177-208	interleukin 6	Homo sapiens	135-153
11053033-3	2000	Triptolide, with an IC(50) of approximately 20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha, or IL-1 beta.	Tetradecanoylphorbol Acetate	177-208	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
11053033-3	2000	Triptolide, with an IC(50) of approximately 20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha, or IL-1 beta.	Tetradecanoylphorbol Acetate	210-213	interleukin 6	Homo sapiens	135-153
11114963-6	2000	RESULTS: In smokers before ibuprofen, monocyte adhesion to native and TNFalpha-stimulated HUVEC was increased (P &lt; 0001 and P &lt; 0.01, respectively), and so were O2- levels in native and PMA-stimulated monocytes (P &lt; 0.01 and P &lt; 0.001, respectively).	Tetradecanoylphorbol Acetate	192-195	tumor necrosis factor	Homo sapiens	70-78
11053031-3	2000	However, phorbol 12-myristate 13-acetate also activates both MAPKs as well as PKC, but this activation is abolished in cells pretreated with the PKC inhibitor GF-109203X.	Tetradecanoylphorbol Acetate	9-40	proline rich transmembrane protein 2	Homo sapiens	78-81
11053031-3	2000	However, phorbol 12-myristate 13-acetate also activates both MAPKs as well as PKC, but this activation is abolished in cells pretreated with the PKC inhibitor GF-109203X.	Tetradecanoylphorbol Acetate	9-40	proline rich transmembrane protein 2	Homo sapiens	145-148
11074886-14	2000	Release of IL-2 and IL-4 from peripheral blood mononuclear cell fractions stimulated with phorbolmyristateacetate and ionomycin was significantly increased in patients with trauma but not from those stimulated with toxic shock syndrome toxin-1.	Tetradecanoylphorbol Acetate	90-113	interleukin 2	Homo sapiens	11-15
11074886-14	2000	Release of IL-2 and IL-4 from peripheral blood mononuclear cell fractions stimulated with phorbolmyristateacetate and ionomycin was significantly increased in patients with trauma but not from those stimulated with toxic shock syndrome toxin-1.	Tetradecanoylphorbol Acetate	90-113	interleukin 4	Homo sapiens	20-24
11093124-6	2000	In transient transfection experiments in phorbol 12-myristate 13-acetate/ionomycin-stimulated EL4 cells, SKAT-2 was found to up-regulate the activity of the IL-4 but not the IL-5 promoter, contrasting with the ability of GATA-3 to activate both promoters.	Tetradecanoylphorbol Acetate	41-72	zinc finger protein 287	Mus musculus	105-111
11126343-10	2000	CONCLUSION: The results suggest that in obese children and adolescents the haemostatic risk factors factor VIIc, vWF-Ag and tPA-Ag are mainly determinated by plasma insulin and triglyceride concentrations, but are primarily independent of body composition and cardiovascular fitness.	Tetradecanoylphorbol Acetate	124-127	insulin	Homo sapiens	165-172
10978848-4	2000	Investigating possible mitogenic signaling pathways we show for the first time that prolactin is coupled to a sustained phospholipase D (PLD) activation, with an efficacy similar to the phorbol ester and astrocytic mitogen 12-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	259-262	prolactin	Homo sapiens	84-93
11050045-0	2000	Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha.	Tetradecanoylphorbol Acetate	98-101	mitogen-activated protein kinase 1	Homo sapiens	45-49
11050045-0	2000	Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha.	Tetradecanoylphorbol Acetate	98-101	mitogen-activated protein kinase 1	Homo sapiens	50-53
11050045-8	2000	These results indicate that ERK activation by HCV core protein may be independent of hepatocyte mitogen-mediated signaling but synergistic with TPA, and HCV core protein may function at MEK1 or farther upstream of that component.	Tetradecanoylphorbol Acetate	144-147	mitogen-activated protein kinase 1	Homo sapiens	28-31
11072155-7	2000	There were weak significant correlations of TGF beta 1 levels with disease stage and the levels of circulating tumor markers (CA125, TPA).	Tetradecanoylphorbol Acetate	133-136	transforming growth factor beta 1	Homo sapiens	44-54
11069028-8	2000	Moreover, the differentiation status of these Raf-responsive cells was more immature upon Raf activation as culture with the differentiation-inducing agent phorbol 12 myristate 13-acetate (PMA) and beta-estradiol resulted in decreased levels of the CD11b and CD18 integrin molecules on the cell surface.	Tetradecanoylphorbol Acetate	156-187	integrin subunit beta 2	Homo sapiens	259-263
11053476-2	2000	Because high glucose and phorbol esters (PMA) increase TGF-beta1 mRNA levels in mesangial cells, this study was designed to characterize these effects on the human TGF-beta1 promoter activity.	Tetradecanoylphorbol Acetate	41-44	transforming growth factor beta 1	Homo sapiens	55-64
11053476-2	2000	Because high glucose and phorbol esters (PMA) increase TGF-beta1 mRNA levels in mesangial cells, this study was designed to characterize these effects on the human TGF-beta1 promoter activity.	Tetradecanoylphorbol Acetate	41-44	transforming growth factor beta 1	Homo sapiens	164-173
11064243-0	2000	Induction of Ro/SSA antigen expression on keratinocyte cell membrane by heat shock and phorbol 12-myristate 13-acetate as well as estradiol and ultraviolet B.	Tetradecanoylphorbol Acetate	87-118	tripartite motif containing 21	Homo sapiens	13-19
11032907-6	2000	Moreover, the combined tPA and plgn treatment markedly inhibited Abeta accumulation.	Tetradecanoylphorbol Acetate	23-26	amyloid beta precursor protein	Homo sapiens	65-70
11032907-8	2000	We interpret the actions of tPA and plgn within the context of the ability of plasmin to degrade Abeta.	Tetradecanoylphorbol Acetate	28-31	amyloid beta precursor protein	Homo sapiens	97-102
11086177-7	2000	In addition, unlike the effects on other inducers of apoptosis, the activation of JNK and of the caspase-3-like protease by GGO was significantly delayed by 12-O-tetradecanoylphorbol-13-acetate (TPA), suggesting that the site of inhibition by TPA might be located upstream of the protease and JNK in the GGO-induced apoptotic signaling pathway.	Tetradecanoylphorbol Acetate	157-193	mitogen-activated protein kinase 8	Homo sapiens	82-85
11056390-3	2000	When human polymorphonuclear leukocytes (PMNs) were stimulated with phorbol myristate acetate (PMA), p40(phox) was translocated to the membrane along with p67(phox), and not was released into the cytosol.	Tetradecanoylphorbol Acetate	68-93	CD33 molecule	Homo sapiens	155-158
11056390-3	2000	When human polymorphonuclear leukocytes (PMNs) were stimulated with phorbol myristate acetate (PMA), p40(phox) was translocated to the membrane along with p67(phox), and not was released into the cytosol.	Tetradecanoylphorbol Acetate	95-98	CD33 molecule	Homo sapiens	155-158
11025443-3	2000	Phorbol-12-myristate-13-acetate (PMA) and thapsigargin increase amylase promoter activity, suggesting that phorbol ester and calcium-dependent protein kinase C (PKC) pathways are also involved.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	161-164
11025443-3	2000	Phorbol-12-myristate-13-acetate (PMA) and thapsigargin increase amylase promoter activity, suggesting that phorbol ester and calcium-dependent protein kinase C (PKC) pathways are also involved.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	161-164
11073105-7	2000	The present PMA-stimulated system was inhibited by the anti-FcgammaRII mAb IV.3, the anti-CD18 mAb MEM 48, and the anti-CD11b mAb 2LPM19c but not by the anti-CD66b mAb 80H3 and N-acetyl-D-glucosamine.	Tetradecanoylphorbol Acetate	12-15	integrin subunit beta 2	Homo sapiens	90-94
11073105-7	2000	The present PMA-stimulated system was inhibited by the anti-FcgammaRII mAb IV.3, the anti-CD18 mAb MEM 48, and the anti-CD11b mAb 2LPM19c but not by the anti-CD66b mAb 80H3 and N-acetyl-D-glucosamine.	Tetradecanoylphorbol Acetate	12-15	CEA cell adhesion molecule 8	Homo sapiens	158-163
11086768-11	2000	Phorbol-12-myristate-13 acetate restored ERK1/2 activation in LPS-tolerant human monocytes.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 3	Homo sapiens	41-47
11086177-7	2000	In addition, unlike the effects on other inducers of apoptosis, the activation of JNK and of the caspase-3-like protease by GGO was significantly delayed by 12-O-tetradecanoylphorbol-13-acetate (TPA), suggesting that the site of inhibition by TPA might be located upstream of the protease and JNK in the GGO-induced apoptotic signaling pathway.	Tetradecanoylphorbol Acetate	157-193	mitogen-activated protein kinase 8	Homo sapiens	293-296
11086177-7	2000	In addition, unlike the effects on other inducers of apoptosis, the activation of JNK and of the caspase-3-like protease by GGO was significantly delayed by 12-O-tetradecanoylphorbol-13-acetate (TPA), suggesting that the site of inhibition by TPA might be located upstream of the protease and JNK in the GGO-induced apoptotic signaling pathway.	Tetradecanoylphorbol Acetate	195-198	mitogen-activated protein kinase 8	Homo sapiens	82-85
11086177-7	2000	In addition, unlike the effects on other inducers of apoptosis, the activation of JNK and of the caspase-3-like protease by GGO was significantly delayed by 12-O-tetradecanoylphorbol-13-acetate (TPA), suggesting that the site of inhibition by TPA might be located upstream of the protease and JNK in the GGO-induced apoptotic signaling pathway.	Tetradecanoylphorbol Acetate	243-246	mitogen-activated protein kinase 8	Homo sapiens	82-85
11069028-8	2000	Moreover, the differentiation status of these Raf-responsive cells was more immature upon Raf activation as culture with the differentiation-inducing agent phorbol 12 myristate 13-acetate (PMA) and beta-estradiol resulted in decreased levels of the CD11b and CD18 integrin molecules on the cell surface.	Tetradecanoylphorbol Acetate	189-192	integrin subunit beta 2	Homo sapiens	259-263
11035786-2	2000	Using the patch-clamp technique, we found that PKC activation by 4-alpha-phorbol 12-myristate 13-acetate (PMA) or rac-1-oleyl-2-acetylglycerol (OAG) caused a substantial reduction in Ba(2+) current through Ca(v)1.2 channels composed of alpha(1)1.2, beta(1b), and alpha(2)delta(1) subunits expressed in tsA-201 cells.	Tetradecanoylphorbol Acetate	106-109	proline rich transmembrane protein 2	Homo sapiens	47-50
11040403-3	2000	In contrast, although neutrophil stimulation with tumor necrosis factor (TNF)-alpha, granulocyte macrophage-colony stimulating factor (GM-CSF), fMLP or phorbol myristate acetate (PMA) gave rise to a massive and prolonged FN-primed O(2)(-) release, a significant impairment of oxidative response occurred in the aged group as a result of GM-CSF or fMLP cell challenge.	Tetradecanoylphorbol Acetate	152-177	formyl peptide receptor 1	Homo sapiens	347-351
11042347-11	2000	The synergistic effect of PMA on IFN-gamma-induced IRF-1 binding activity was observed in macrophage cell line J774 cells as well as RAW 264.7 cells, but not in thioglycollate-elicited peritoneal macrophages.	Tetradecanoylphorbol Acetate	26-29	interferon gamma	Mus musculus	33-42
11023507-2	2000	Expression of GPVI is increased in the megakaryoblastic cell lines HEL and CMK on differentiation with the phorbol ester phorbol 12-myristate 13-acetate (PMA), along with the Fc receptor gamma-chain (FcR gamma-chain).	Tetradecanoylphorbol Acetate	121-152	C-X-C motif chemokine ligand 9	Homo sapiens	75-78
11023507-2	2000	Expression of GPVI is increased in the megakaryoblastic cell lines HEL and CMK on differentiation with the phorbol ester phorbol 12-myristate 13-acetate (PMA), along with the Fc receptor gamma-chain (FcR gamma-chain).	Tetradecanoylphorbol Acetate	154-157	C-X-C motif chemokine ligand 9	Homo sapiens	75-78
11004668-2	2000	The PKC activator phorbol myristate acetate (PMA) induced the transition of elongated fibroblast-like cells into CS cells and stimulated locomotion.	Tetradecanoylphorbol Acetate	18-43	protein kinase C alpha	Homo sapiens	4-7
10915787-2	2000	Treatment of leukemic cells with phorbol 12-myristate 13-acetate (PMA) induces a short-lived phosphorylation and activation of stress-activated protein kinase (SAPK) and cellular differentiation.	Tetradecanoylphorbol Acetate	33-64	mitogen-activated protein kinase 9	Homo sapiens	127-158
10915787-2	2000	Treatment of leukemic cells with phorbol 12-myristate 13-acetate (PMA) induces a short-lived phosphorylation and activation of stress-activated protein kinase (SAPK) and cellular differentiation.	Tetradecanoylphorbol Acetate	33-64	mitogen-activated protein kinase 9	Homo sapiens	160-164
10915787-2	2000	Treatment of leukemic cells with phorbol 12-myristate 13-acetate (PMA) induces a short-lived phosphorylation and activation of stress-activated protein kinase (SAPK) and cellular differentiation.	Tetradecanoylphorbol Acetate	66-69	mitogen-activated protein kinase 9	Homo sapiens	127-158
10915787-2	2000	Treatment of leukemic cells with phorbol 12-myristate 13-acetate (PMA) induces a short-lived phosphorylation and activation of stress-activated protein kinase (SAPK) and cellular differentiation.	Tetradecanoylphorbol Acetate	66-69	mitogen-activated protein kinase 9	Homo sapiens	160-164
10915787-4	2000	PMA treatment rapidly induced hVH5 transcripts in these cells, and induced expression of M3/6 completely inhibited PMA-stimulated phosphorylation of SAPK, suggesting a feedback loop to control SAPK activity.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 9	Homo sapiens	149-153
10915787-4	2000	PMA treatment rapidly induced hVH5 transcripts in these cells, and induced expression of M3/6 completely inhibited PMA-stimulated phosphorylation of SAPK, suggesting a feedback loop to control SAPK activity.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 9	Homo sapiens	193-197
10915787-4	2000	PMA treatment rapidly induced hVH5 transcripts in these cells, and induced expression of M3/6 completely inhibited PMA-stimulated phosphorylation of SAPK, suggesting a feedback loop to control SAPK activity.	Tetradecanoylphorbol Acetate	115-118	mitogen-activated protein kinase 9	Homo sapiens	149-153
10915787-4	2000	PMA treatment rapidly induced hVH5 transcripts in these cells, and induced expression of M3/6 completely inhibited PMA-stimulated phosphorylation of SAPK, suggesting a feedback loop to control SAPK activity.	Tetradecanoylphorbol Acetate	115-118	mitogen-activated protein kinase 9	Homo sapiens	193-197
11004668-2	2000	The PKC activator phorbol myristate acetate (PMA) induced the transition of elongated fibroblast-like cells into CS cells and stimulated locomotion.	Tetradecanoylphorbol Acetate	45-48	protein kinase C alpha	Homo sapiens	4-7
10918054-4	2000	Treatment with PMA or bryostatin 1 increased nuclear protein binding to MIE1, a c-myc intron 1 element that defines an RFX1-binding X box.	Tetradecanoylphorbol Acetate	15-18	regulatory factor X1	Homo sapiens	119-123
11004668-5	2000	CS formation and stimulated locomotion correlated closely with a marked redistribution from the cytosol to the membrane of PKC isoforms alpha, beta1 and gamma in the early phase (0.5 to 2 hr) following activation with PMA.	Tetradecanoylphorbol Acetate	218-221	protein kinase C alpha	Homo sapiens	123-158
10918054-7	2000	PMA treatment increased RFX1 in the nuclear fraction and decreased it in the cytosol without affecting total RFX1.	Tetradecanoylphorbol Acetate	0-3	regulatory factor X1	Homo sapiens	24-28
11033420-3	2000	Present study aims to investigate whether neutrophils primed by 4beta-phorbol 12beta-myristate 13alpha-acetate (PMA) affect the productions of H(2)O(2) and lipid peroxide (LPO), NF-kappaB activation and cytokine production in pancreatic acinar cells, and whether these alterations were inhibited by N-acetylcysteine (NAC) and superoxide dismutase (SOD).	Tetradecanoylphorbol Acetate	112-115	superoxide dismutase 1	Homo sapiens	326-346
11041251-3	2000	Pretreatment of the cells with muscarinic receptor agonist, oxotremorine M (Oxo-M), enhanced IL-2 production induced by phorbol 12-myristate 13-acetate (PMA)/A23187, while Oxo-M by itself did not affect IL-2 production.	Tetradecanoylphorbol Acetate	120-151	interleukin 2	Homo sapiens	93-97
11041251-3	2000	Pretreatment of the cells with muscarinic receptor agonist, oxotremorine M (Oxo-M), enhanced IL-2 production induced by phorbol 12-myristate 13-acetate (PMA)/A23187, while Oxo-M by itself did not affect IL-2 production.	Tetradecanoylphorbol Acetate	153-156	interleukin 2	Homo sapiens	93-97
11065173-3	2000	Pimobendan significantly decreased the expression of luciferase protein in A549 cells transfected with the NF-kappaB reporter plasmid, stimulated with interleukin (IL)-1beta, tumor necrosis factor-alpha, or phorbol 12-myristate 13 acetate.	Tetradecanoylphorbol Acetate	207-238	nuclear factor kappa B subunit 1	Homo sapiens	107-116
11023547-5	2000	These polyphenols blocked TPA-induced phosphorylation of IkappaBalpha at Ser32 in the same concentration range.	Tetradecanoylphorbol Acetate	26-29	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	57-69
11014215-7	2000	In addition, the GnRHa- and TPA-mediated decrease in the human GnRHR promoter activity was reversed by a specific protein kinase C (PKC) inhibitor, GF109203X, or depletion of PKC by TPA pretreatment.	Tetradecanoylphorbol Acetate	28-31	proline rich transmembrane protein 2	Homo sapiens	114-130
11014215-7	2000	In addition, the GnRHa- and TPA-mediated decrease in the human GnRHR promoter activity was reversed by a specific protein kinase C (PKC) inhibitor, GF109203X, or depletion of PKC by TPA pretreatment.	Tetradecanoylphorbol Acetate	28-31	proline rich transmembrane protein 2	Homo sapiens	132-135
11014215-7	2000	In addition, the GnRHa- and TPA-mediated decrease in the human GnRHR promoter activity was reversed by a specific protein kinase C (PKC) inhibitor, GF109203X, or depletion of PKC by TPA pretreatment.	Tetradecanoylphorbol Acetate	28-31	proline rich transmembrane protein 2	Homo sapiens	175-178
11014215-7	2000	In addition, the GnRHa- and TPA-mediated decrease in the human GnRHR promoter activity was reversed by a specific protein kinase C (PKC) inhibitor, GF109203X, or depletion of PKC by TPA pretreatment.	Tetradecanoylphorbol Acetate	182-185	proline rich transmembrane protein 2	Homo sapiens	175-178
11033420-3	2000	Present study aims to investigate whether neutrophils primed by 4beta-phorbol 12beta-myristate 13alpha-acetate (PMA) affect the productions of H(2)O(2) and lipid peroxide (LPO), NF-kappaB activation and cytokine production in pancreatic acinar cells, and whether these alterations were inhibited by N-acetylcysteine (NAC) and superoxide dismutase (SOD).	Tetradecanoylphorbol Acetate	112-115	superoxide dismutase 1	Homo sapiens	348-351
11033420-4	2000	Neutrophils generated ROS by stimulation with PMA, which was inhibited by NAC and SOD.	Tetradecanoylphorbol Acetate	46-49	superoxide dismutase 1	Homo sapiens	82-85
11061546-15	2000	In agreement with the semiquantitative RT-PCR results, Western blot analysis detected a decrease in ERalpha and ERbeta proteins levels in hGLCs after treatment with hCG (10 IU/mL), GnRH (0.1 micromol/L), 8-bromo-cAMP (1 mmol/L), forskolin (10 micromol/L), or phorbol 12-myristate 13 acetate (10 micromol/L).	Tetradecanoylphorbol Acetate	259-290	estrogen receptor 1	Homo sapiens	100-107
11066030-7	2000	Preincubation with 1 microM of phorbol 12-myristate 13-acetate (PMA), a PKC-activating phorbol ester attenuated the ADR (c. 95%) and restored the postrecovery plateau almost to baseline levels (98 +/- 0.7%; p &gt; 0.10 compared with baseline CBF).	Tetradecanoylphorbol Acetate	31-62	proline rich transmembrane protein 2	Homo sapiens	72-75
11066030-7	2000	Preincubation with 1 microM of phorbol 12-myristate 13-acetate (PMA), a PKC-activating phorbol ester attenuated the ADR (c. 95%) and restored the postrecovery plateau almost to baseline levels (98 +/- 0.7%; p &gt; 0.10 compared with baseline CBF).	Tetradecanoylphorbol Acetate	64-67	proline rich transmembrane protein 2	Homo sapiens	72-75
11066030-8	2000	With respect to the ADR, the PMA protective effect was lost in the presence of the selective PKC inhibitor myristoylated epidermal growth factor peptide 651d-658 (Myr-PKCI; 10 microM).	Tetradecanoylphorbol Acetate	29-32	proline rich transmembrane protein 2	Homo sapiens	93-96
11039466-3	2000	Phorbol 12-myristate 13-acetate (TPA) significantly stimulated CCK release.	Tetradecanoylphorbol Acetate	0-31	promotion susceptibility QTL 1	Mus musculus	33-36
11095401-0	2000	Survival mechanisms induced by 12-O-tetradecanoylphorbol-13-acetate in normal human melanocytes include inhibition of apoptosis and increased Bcl-2 expression.	Tetradecanoylphorbol Acetate	31-67	BCL2 apoptosis regulator	Homo sapiens	142-147
11095401-7	2000	Following withdrawal of TPA from melanocytes, the expression of Bcl-2 decreased steadily.	Tetradecanoylphorbol Acetate	24-27	BCL2 apoptosis regulator	Homo sapiens	64-69
11095401-9	2000	These results suggest that TPA plays an important role in stimulating the growth of melanocytes by promoting anti-apoptotic mechanisms associated with high levels of Bcl-2.	Tetradecanoylphorbol Acetate	27-30	BCL2 apoptosis regulator	Homo sapiens	166-171
11034109-3	2000	Melatonin enhances IL-2 production by Jurkat cells activated by either phytohemagglutinin (PHA) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	99-124	interleukin 2	Homo sapiens	19-23
11034109-3	2000	Melatonin enhances IL-2 production by Jurkat cells activated by either phytohemagglutinin (PHA) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	126-129	interleukin 2	Homo sapiens	19-23
11006316-4	2000	The luminol chemiluminescence measuring total ROS production of blood PMN stimulated by either a phorbol ester (PMA) or a chemoattractant peptide, formyl-Met-Leu-Phe (fMLP) was significantly inhibited by prostasomes.	Tetradecanoylphorbol Acetate	112-115	formyl peptide receptor 1	Homo sapiens	147-165
11057852-4	2000	Insulin sensitivity was independently and reversibly associated with PAI-1 (p = 0.014) and directly with tPA activity (p = 0.001).	Tetradecanoylphorbol Acetate	105-108	insulin	Homo sapiens	0-7
11087070-6	2000	Both phorbol-12-myristate-13-acetate (PMA) and DIDS can induce increased translocation of p47-phox of the neutrophil to the membrane fraction, which is inhibited by STP pretreatment.	Tetradecanoylphorbol Acetate	5-36	NSFL1 (p97) cofactor (p47)	Mus musculus	90-93
11087070-6	2000	Both phorbol-12-myristate-13-acetate (PMA) and DIDS can induce increased translocation of p47-phox of the neutrophil to the membrane fraction, which is inhibited by STP pretreatment.	Tetradecanoylphorbol Acetate	38-41	NSFL1 (p97) cofactor (p47)	Mus musculus	90-93
11018520-2	2000	However, their activators (extracellular signal related kinase (ERK)1/ERK2) were stimulated normally in mitogen- and stress-activated protein kinase (MSK)1-/- and wild type cells in response to tetradecanoylphorbol acetate (TPA) and epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	194-222	mitogen-activated protein kinase 1	Mus musculus	70-74
11018520-2	2000	However, their activators (extracellular signal related kinase (ERK)1/ERK2) were stimulated normally in mitogen- and stress-activated protein kinase (MSK)1-/- and wild type cells in response to tetradecanoylphorbol acetate (TPA) and epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	224-227	mitogen-activated protein kinase 1	Mus musculus	70-74
11018526-1	2000	The tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 2 (PAI-2) genes are differentially regulated by 12-phorbol 13-myristate acetate (PMA) in HT-1080 fibrosarcoma cells.	Tetradecanoylphorbol Acetate	167-170	plasminogen activator, tissue type	Homo sapiens	4-37
11018526-1	2000	The tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 2 (PAI-2) genes are differentially regulated by 12-phorbol 13-myristate acetate (PMA) in HT-1080 fibrosarcoma cells.	Tetradecanoylphorbol Acetate	167-170	plasminogen activator, tissue type	Homo sapiens	39-43
11048644-0	2000	Responsive site on the thrombospondin-1 promotor to down-regulation by phorbol 12-myristate 13-acetate in porcine aortic endothelial cells.	Tetradecanoylphorbol Acetate	71-102	thrombospondin 1	Homo sapiens	23-39
11048644-2	2000	We found that the synthesis of TSP-1 in porcine aortic endothelial (PAE) cells was decreased in a dose-dependent manner by phorbol 12-myristate 13-acetate (PMA) treatment in porcine aortic endothelial (PAE) cells.	Tetradecanoylphorbol Acetate	123-154	thrombospondin 1	Homo sapiens	31-36
11048644-2	2000	We found that the synthesis of TSP-1 in porcine aortic endothelial (PAE) cells was decreased in a dose-dependent manner by phorbol 12-myristate 13-acetate (PMA) treatment in porcine aortic endothelial (PAE) cells.	Tetradecanoylphorbol Acetate	156-159	thrombospondin 1	Homo sapiens	31-36
11018520-3	2000	TPA and EGF induced the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser-133 and ATF1 at Ser-63 in wild type cells and this was abolished by inhibition of the mitogen-activated protein kinase cascade.	Tetradecanoylphorbol Acetate	0-3	cAMP responsive element binding protein 1	Mus musculus	43-88
11018520-3	2000	TPA and EGF induced the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser-133 and ATF1 at Ser-63 in wild type cells and this was abolished by inhibition of the mitogen-activated protein kinase cascade.	Tetradecanoylphorbol Acetate	0-3	cAMP responsive element binding protein 1	Mus musculus	90-94
11018520-4	2000	In contrast, the TPA- and EGF-induced phosphorylation of CREB/ATF1 was barely detectable in MSK1-/- cells.	Tetradecanoylphorbol Acetate	17-20	cAMP responsive element binding protein 1	Mus musculus	57-61
11018470-2	2000	In SK-N-MC human neuroblastoma cells, phorbol ester (TPA) activation of PLD was enhanced by overexpressing myristoylated alanine-rich C kinase substrate (MARCKS).	Tetradecanoylphorbol Acetate	53-56	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	72-75
11018470-5	2000	TPA-stimulated PLD activity was higher in both intact and digitonin-permeabilized M22 cells than in vector controls.	Tetradecanoylphorbol Acetate	0-3	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	15-18
11018470-9	2000	Disruption of cholesterol-rich DIFs with digitonin, cyclodextrin or filipin potentiated activation of PLD by TPA.	Tetradecanoylphorbol Acetate	109-112	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	102-105
10996653-1	2000	Spontaneous and glucocorticoid (fluocinolone acetonide, FA)-induced apoptosis of primary mouse thymocytes was inhibited by protein kinase C (PKC) activators such as bryostatin-1 and phorbol ester 12-O-tetradecanoyl-phorbol-13 acetate (TPA) within the first 2-4 h of incubation but was enhanced upon prolonged treatment.	Tetradecanoylphorbol Acetate	235-238	protein kinase C, alpha	Mus musculus	141-144
10887171-9	2000	The diacylglycerol mimic phorbol 12-myristate 13-acetate was sufficient to cause translocation of PKC alpha, but not the mobility shift.	Tetradecanoylphorbol Acetate	25-56	protein kinase C, alpha	Mus musculus	98-107
10996653-1	2000	Spontaneous and glucocorticoid (fluocinolone acetonide, FA)-induced apoptosis of primary mouse thymocytes was inhibited by protein kinase C (PKC) activators such as bryostatin-1 and phorbol ester 12-O-tetradecanoyl-phorbol-13 acetate (TPA) within the first 2-4 h of incubation but was enhanced upon prolonged treatment.	Tetradecanoylphorbol Acetate	196-233	protein kinase C, alpha	Mus musculus	141-144
10996653-4	2000	Upon prolonged TPA treatment all PKC isoenzymes became downregulated, albeit at different rates (PKCdelta&gt;alpha&gt;mu&gt;beta,theta&gt;&gt;eta,zeta).	Tetradecanoylphorbol Acetate	15-18	protein kinase C, alpha	Mus musculus	33-36
10996653-6	2000	It is concluded that the early anti-apoptotic effect of TPA depends on the activation of n-type PKC isoenzymes, whereas stimulation of spontaneous and FA-induced apoptosis by TPA ensues, at least partially, from a downregulation (or inactivation) of anti-apoptotic PKC species, i.e. in primary thymocytes PKC activation is primarily involved in a negative regulation of apoptosis.	Tetradecanoylphorbol Acetate	56-59	protein kinase C, alpha	Mus musculus	96-99
10980241-3	2000	This effect was mimicked by co-treatment with a growth factor (aFGF, bFGF or BDNF; but not GDNF, IGF-1, EGF or TGF) and the neurotransmitter 5-HT (but not GABA, dopamine, glutamate) and/or a protein kinase activator (IBMX, forskolin, TPA).	Tetradecanoylphorbol Acetate	234-237	fibroblast growth factor 1	Homo sapiens	63-67
10964506-4	2000	Treatment of cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA), an activator of PKC, suppressed the release of cytochrome c from mitochondria and the activation of caspase-3(-like) proteases in inostamycin-treated cells, but not in other anticancer drug-treated cells.	Tetradecanoylphorbol Acetate	24-61	cytochrome c, somatic	Homo sapiens	116-128
10964506-4	2000	Treatment of cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA), an activator of PKC, suppressed the release of cytochrome c from mitochondria and the activation of caspase-3(-like) proteases in inostamycin-treated cells, but not in other anticancer drug-treated cells.	Tetradecanoylphorbol Acetate	24-61	caspase 3	Homo sapiens	169-184
10964506-4	2000	Treatment of cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA), an activator of PKC, suppressed the release of cytochrome c from mitochondria and the activation of caspase-3(-like) proteases in inostamycin-treated cells, but not in other anticancer drug-treated cells.	Tetradecanoylphorbol Acetate	63-66	cytochrome c, somatic	Homo sapiens	116-128
10964506-4	2000	Treatment of cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA), an activator of PKC, suppressed the release of cytochrome c from mitochondria and the activation of caspase-3(-like) proteases in inostamycin-treated cells, but not in other anticancer drug-treated cells.	Tetradecanoylphorbol Acetate	63-66	caspase 3	Homo sapiens	169-184
10980241-3	2000	This effect was mimicked by co-treatment with a growth factor (aFGF, bFGF or BDNF; but not GDNF, IGF-1, EGF or TGF) and the neurotransmitter 5-HT (but not GABA, dopamine, glutamate) and/or a protein kinase activator (IBMX, forskolin, TPA).	Tetradecanoylphorbol Acetate	234-237	fibroblast growth factor 2	Homo sapiens	69-73
11054092-1	2000	The human monocytic cell line THP-1 differentiates along the macrophage line after phorbol-12-myristate-13-acetate (PMA) supplementation and can be stimulated to secrete tumour necrosis factor alpha (TNF-alpha) by interferon gamma (IFN-gamma) addition.	Tetradecanoylphorbol Acetate	83-114	tumor necrosis factor	Homo sapiens	200-209
10972960-5	2000	Pharmacological studies using the PKC activator, phorbol myristate acetate, and inhibitors, calphostin-C, and staurosporine, demonstrated PKC activity to be inversely related to NCAM polysialylation in the mouse neuro-2A cell line.	Tetradecanoylphorbol Acetate	49-74	neural cell adhesion molecule 1	Mus musculus	178-182
10908559-7	2000	The ability of Id-1 to postpone, but not prevent, senescence may be related to partial inhibition of p16 expression, as the Id-1-overexpressing cultures displayed a decreased capacity for 12-O-tetradecanoylphorbol-13-acetate-mediated p16 induction.	Tetradecanoylphorbol Acetate	188-224	cyclin dependent kinase inhibitor 2A	Homo sapiens	234-237
10973802-5	2000	This recovery of GJIC from TPA inhibition was partly correlated with hindered hyperphosphorylation of Cx43.	Tetradecanoylphorbol Acetate	27-30	gap junction protein, alpha 1	Rattus norvegicus	102-106
10961874-3	2000	U937 cells constitutively express the antiapoptotic protein Bcl-2; but during differentiation, in response to the phorbol ester PMA (phorbol 12 beta-myristate 13 alpha-acetate), Mcl-1 is transiently induced.	Tetradecanoylphorbol Acetate	128-131	BCL2 apoptosis regulator	Homo sapiens	60-65
10882716-5	2000	Lead induced VEGF mRNA 3-fold and VEGF protein approximately 2-fold with maximum mRNA induction following incubation with 10 micrometer lead acetate for 24 h. Phorbol 12-myristate 13-acetate (PMA), a potent protein kinase C (PKC) activator, increased VEGF mRNA 2-fold and PKC inhibition by GF-109203 completely blocked VEGF induction by lead.	Tetradecanoylphorbol Acetate	159-190	protein kinase C alpha	Homo sapiens	225-228
10882716-5	2000	Lead induced VEGF mRNA 3-fold and VEGF protein approximately 2-fold with maximum mRNA induction following incubation with 10 micrometer lead acetate for 24 h. Phorbol 12-myristate 13-acetate (PMA), a potent protein kinase C (PKC) activator, increased VEGF mRNA 2-fold and PKC inhibition by GF-109203 completely blocked VEGF induction by lead.	Tetradecanoylphorbol Acetate	159-190	protein kinase C alpha	Homo sapiens	272-275
11094642-5	2000	In addition to these phenotypical changes, IL-4 primed the phorbol-12-myristate-13-acetate (PMA)-induced luminol-dependent chemiluminescence response (LDCL) by normal human monocytes; this priming effect was abrogated in the presence of Lyprinol, or of BW B70C.	Tetradecanoylphorbol Acetate	59-90	interleukin 4	Homo sapiens	43-47
11094642-5	2000	In addition to these phenotypical changes, IL-4 primed the phorbol-12-myristate-13-acetate (PMA)-induced luminol-dependent chemiluminescence response (LDCL) by normal human monocytes; this priming effect was abrogated in the presence of Lyprinol, or of BW B70C.	Tetradecanoylphorbol Acetate	92-95	interleukin 4	Homo sapiens	43-47
10993217-3	2000	The dissociation constants (Kd"s) of TPA to PDI, histone H1 and PKCalpha were determined to be 1.03 x 10(-6) M, 5.70 x 10(-7) M, and 4.00 x 10(-7) m, respectively, by the surface plasmon resonance (SPR) method.	Tetradecanoylphorbol Acetate	37-40	protein kinase C alpha	Homo sapiens	64-72
10960082-3	2000	Astrocyte cultures stimulated with IL-1beta or the phorbol ester, PMA significantly increased PGE(2) secretion.	Tetradecanoylphorbol Acetate	66-69	interleukin 1 beta	Mus musculus	35-43
11054092-3	2000	In addition, we found that iron administration to PMA-differentiating cells induced the expression of TNF-alpha mRNA and TNF-alpha secretion to levels even higher than those induced by IFN-gamma alone.	Tetradecanoylphorbol Acetate	50-53	tumor necrosis factor	Homo sapiens	102-111
11054092-3	2000	In addition, we found that iron administration to PMA-differentiating cells induced the expression of TNF-alpha mRNA and TNF-alpha secretion to levels even higher than those induced by IFN-gamma alone.	Tetradecanoylphorbol Acetate	50-53	tumor necrosis factor	Homo sapiens	121-130
11054092-5	2000	In contrast, preincubation of the cells with iron before PMA induction resulted in a decrease of the TNF-alpha secretion induced by IFN-gamma, whereas the opposite was true after preincubation with desferrioxamine.	Tetradecanoylphorbol Acetate	57-60	tumor necrosis factor	Homo sapiens	101-110
11054092-5	2000	In contrast, preincubation of the cells with iron before PMA induction resulted in a decrease of the TNF-alpha secretion induced by IFN-gamma, whereas the opposite was true after preincubation with desferrioxamine.	Tetradecanoylphorbol Acetate	57-60	interferon gamma	Homo sapiens	132-141
10961574-5	2000	Bradykinin stimulates tPA liberation and nitric oxide formation.	Tetradecanoylphorbol Acetate	22-25	kininogen 1	Canis lupus familiaris	0-10
11042674-7	2000	Accordingly, PKC activation by TPA treatment was associated with a significant expression of the cdk/cyclin inhibitor p21WAF/CIP/sdi-1 in the adherent population and subsequent G0/G1 cell cycle arrest.	Tetradecanoylphorbol Acetate	31-34	cyclin dependent kinase inhibitor 1A	Homo sapiens	129-134
11042674-11	2000	In this context, incubation with the caspase-3/caspase-7 specific tetrapeptide inhibitor DEVD prior to TPA treatment prevented an accumulation of cells in subG1, respectively, demonstrating an involvement of these caspases.	Tetradecanoylphorbol Acetate	103-106	caspase 3	Homo sapiens	37-46
11810558-7	2000	We also examined the uptake of the two fluoroquinolones in phorbol 12 myristate 13-acetate (PMA)-stimulated adherent THP-1 cells (THP-1 macrophages).	Tetradecanoylphorbol Acetate	59-90	GLI family zinc finger 2	Homo sapiens	117-122
11465069-6	2000	Phorbol esters such as the tumor-promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) or diacylglycerol (DAG) activate classical and novel PKC isoforms.	Tetradecanoylphorbol Acetate	42-78	proline rich transmembrane protein 2	Homo sapiens	138-141
11465069-6	2000	Phorbol esters such as the tumor-promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) or diacylglycerol (DAG) activate classical and novel PKC isoforms.	Tetradecanoylphorbol Acetate	80-83	proline rich transmembrane protein 2	Homo sapiens	138-141
10842166-5	2000	Treatment of PC12 cells with phorbol ester (2 micrometer 12-O-tetradecanoylphorbol-13-acetate (TPA)) gives rise to a new Egr1-containing complex.	Tetradecanoylphorbol Acetate	57-93	early growth response 1	Rattus norvegicus	121-125
10842166-5	2000	Treatment of PC12 cells with phorbol ester (2 micrometer 12-O-tetradecanoylphorbol-13-acetate (TPA)) gives rise to a new Egr1-containing complex.	Tetradecanoylphorbol Acetate	95-98	early growth response 1	Rattus norvegicus	121-125
10842166-6	2000	TPA treatment reduces the steady-state levels of the Sp1 protein and leads to the appearance of immunoreactive Egr1 protein within 30-60 min.	Tetradecanoylphorbol Acetate	0-3	early growth response 1	Rattus norvegicus	111-115
10842166-9	2000	An oligonucleotide encompassing the AP-1/E-box sequence of the rat TH promoter competes in electrophoretic mobility shift assays for binding of nuclear extracts from control and TPA-treated cells to an oligonucleotide containing the Sp1/Egr1 element, indicating that these two enhancers may interact.	Tetradecanoylphorbol Acetate	178-181	early growth response 1	Rattus norvegicus	237-241
10934041-3	2000	TPA treatment resulted in transient PKC(&amp;agr;) activation accompanied by translocation of the enzyme into membrane and nuclear compartments, and was followed by subsequent downregulation.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	36-39
10934041-4	2000	TPA-induced inhibition of DNA synthesis was prevented by a PKC-antagonist and was reproduced by microinjection of recombinant PKCalpha, indicating that activation of this isoenzyme was required and sufficient for growth inhibitory effects.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	59-62
10934041-4	2000	TPA-induced inhibition of DNA synthesis was prevented by a PKC-antagonist and was reproduced by microinjection of recombinant PKCalpha, indicating that activation of this isoenzyme was required and sufficient for growth inhibitory effects.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	126-134
11051279-5	2000	CD(40L) expression was found significantly higher on in (vitro activated CD3 [with phorbol myristate acetate (PMA) and ionomycine Ca2+ at 12 hr of culture] from CU patients compared to that of contact dermatitis and normal individuals.	Tetradecanoylphorbol Acetate	83-108	CD40 ligand	Homo sapiens	0-6
11051279-5	2000	CD(40L) expression was found significantly higher on in (vitro activated CD3 [with phorbol myristate acetate (PMA) and ionomycine Ca2+ at 12 hr of culture] from CU patients compared to that of contact dermatitis and normal individuals.	Tetradecanoylphorbol Acetate	110-113	CD40 ligand	Homo sapiens	0-6
10946303-6	2000	The 12-O-tetradecanoylphorbol 13-acetate (TPA), a PKC activator, also stimulated COX-2 expression, this effect being inhibited by genistein or herbimycin.	Tetradecanoylphorbol Acetate	4-40	prostaglandin-endoperoxide synthase 2	Homo sapiens	81-86
10946303-6	2000	The 12-O-tetradecanoylphorbol 13-acetate (TPA), a PKC activator, also stimulated COX-2 expression, this effect being inhibited by genistein or herbimycin.	Tetradecanoylphorbol Acetate	42-45	prostaglandin-endoperoxide synthase 2	Homo sapiens	81-86
10946303-8	2000	TPA stimulated both NF-kappaB DNA-protein binding and COX-2 promoter activity, these effects being inhibited by genistein, herbimycin, or pyrolidine dithiocarbamate.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Homo sapiens	54-59
11012749-6	2000	After in vitro stimulation with phorbol 12-myristate 13-acetate and calcium ionophore in the presence of Brefeldin A, higher frequencies of intracellular IFN-gamma+ DN TCRalphabeta+ T cells were detected in all three investigated organs of infected mice compared with those of uninfected mice.	Tetradecanoylphorbol Acetate	32-63	interferon gamma	Mus musculus	154-163
11810558-7	2000	We also examined the uptake of the two fluoroquinolones in phorbol 12 myristate 13-acetate (PMA)-stimulated adherent THP-1 cells (THP-1 macrophages).	Tetradecanoylphorbol Acetate	92-95	GLI family zinc finger 2	Homo sapiens	117-122
11810558-7	2000	We also examined the uptake of the two fluoroquinolones in phorbol 12 myristate 13-acetate (PMA)-stimulated adherent THP-1 cells (THP-1 macrophages).	Tetradecanoylphorbol Acetate	92-95	GLI family zinc finger 2	Homo sapiens	130-135
10969179-9	2000	In THP-1 myeloid leukemia cells pretreated with TPA (to induce receptors for IFN-gamma), IFN-gamma induced SOCS-2.	Tetradecanoylphorbol Acetate	48-51	interferon gamma	Homo sapiens	77-86
10953159-9	2000	However, 12-O-tetradecanoylphorbol 13-acetate (TPA) induced TNFalpha secretion into medium up to 1600 pg/ml/day.	Tetradecanoylphorbol Acetate	9-45	tumor necrosis factor	Homo sapiens	60-68
10969179-9	2000	In THP-1 myeloid leukemia cells pretreated with TPA (to induce receptors for IFN-gamma), IFN-gamma induced SOCS-2.	Tetradecanoylphorbol Acetate	48-51	interferon gamma	Homo sapiens	89-98
10945851-6	2000	Contraction was abolished by the protein kinase C (PKC) inhibitor calphostin C (1 microM), but was not affected by the myosin light chain kinase inhibitor KT5926 (1 microM), suggesting that activation of myosin light chain kinase was suppressed by phorbol-12-myristate-13-acetate or via PKC.	Tetradecanoylphorbol Acetate	248-279	myosin light chain kinase, smooth muscle	Cavia porcellus	204-229
10953159-9	2000	However, 12-O-tetradecanoylphorbol 13-acetate (TPA) induced TNFalpha secretion into medium up to 1600 pg/ml/day.	Tetradecanoylphorbol Acetate	47-50	tumor necrosis factor	Homo sapiens	60-68
10972665-6	2000	RESULTS: Based on the use of an anti-PKC-delta monoclonal antibody, TPA was observed to cause a rapid decrease in total PKC-delta content, which then returned to near control levels by seven days of treatment.	Tetradecanoylphorbol Acetate	68-71	PRKCD	Sus scrofa	37-46
10972665-6	2000	RESULTS: Based on the use of an anti-PKC-delta monoclonal antibody, TPA was observed to cause a rapid decrease in total PKC-delta content, which then returned to near control levels by seven days of treatment.	Tetradecanoylphorbol Acetate	68-71	PRKCD	Sus scrofa	120-129
10972665-7	2000	Immunofluorescence indicated that PKC-delta had a cytoskeletal localization within the cells, and a subtle cytoskeletal rearrangement occurred upon exposure to TPA.	Tetradecanoylphorbol Acetate	160-163	PRKCD	Sus scrofa	34-43
10972665-8	2000	Western immunoblots showed that PKC-delta did not undergo the expected membrane translocation upon activation by TPA, but simply disappeared immediately from the cytosolic compartment.	Tetradecanoylphorbol Acetate	113-116	PRKCD	Sus scrofa	32-41
10972665-13	2000	CONCLUSIONS: The present data indicate that the localization of PKC-delta and subsequent redistribution within the LLC-PK1 cells in response to TPA treatment is highly unique and distinct from that of PKC-epsilon and PKC-alpha.	Tetradecanoylphorbol Acetate	144-147	PRKCD	Sus scrofa	64-73
10953159-11	2000	post-TPA treatment TNFalpha mRNA levels were increased 15-fold compared to pre-treatment levels.	Tetradecanoylphorbol Acetate	5-8	tumor necrosis factor	Homo sapiens	19-27
10829029-4	2000	0 h. Activation of PKC also resulted in a decrease in trans-epithelial Na(+) reabsorption for up to 48 h. PMA activation of PKC resulted in negative feedback inhibition of PKC protein levels beginning within 4 h. Both beta and gammaENaC levels, as well as transport tended toward pretreatment values after 48 h of PMA treatment.	Tetradecanoylphorbol Acetate	106-109	proline rich transmembrane protein 2	Homo sapiens	19-22
10829029-4	2000	0 h. Activation of PKC also resulted in a decrease in trans-epithelial Na(+) reabsorption for up to 48 h. PMA activation of PKC resulted in negative feedback inhibition of PKC protein levels beginning within 4 h. Both beta and gammaENaC levels, as well as transport tended toward pretreatment values after 48 h of PMA treatment.	Tetradecanoylphorbol Acetate	314-317	proline rich transmembrane protein 2	Homo sapiens	19-22
10829029-4	2000	0 h. Activation of PKC also resulted in a decrease in trans-epithelial Na(+) reabsorption for up to 48 h. PMA activation of PKC resulted in negative feedback inhibition of PKC protein levels beginning within 4 h. Both beta and gammaENaC levels, as well as transport tended toward pretreatment values after 48 h of PMA treatment.	Tetradecanoylphorbol Acetate	106-109	proline rich transmembrane protein 2	Homo sapiens	124-127
10829029-4	2000	0 h. Activation of PKC also resulted in a decrease in trans-epithelial Na(+) reabsorption for up to 48 h. PMA activation of PKC resulted in negative feedback inhibition of PKC protein levels beginning within 4 h. Both beta and gammaENaC levels, as well as transport tended toward pretreatment values after 48 h of PMA treatment.	Tetradecanoylphorbol Acetate	314-317	proline rich transmembrane protein 2	Homo sapiens	124-127
10829029-4	2000	0 h. Activation of PKC also resulted in a decrease in trans-epithelial Na(+) reabsorption for up to 48 h. PMA activation of PKC resulted in negative feedback inhibition of PKC protein levels beginning within 4 h. Both beta and gammaENaC levels, as well as transport tended toward pretreatment values after 48 h of PMA treatment.	Tetradecanoylphorbol Acetate	106-109	proline rich transmembrane protein 2	Homo sapiens	124-127
10829029-4	2000	0 h. Activation of PKC also resulted in a decrease in trans-epithelial Na(+) reabsorption for up to 48 h. PMA activation of PKC resulted in negative feedback inhibition of PKC protein levels beginning within 4 h. Both beta and gammaENaC levels, as well as transport tended toward pretreatment values after 48 h of PMA treatment.	Tetradecanoylphorbol Acetate	314-317	proline rich transmembrane protein 2	Homo sapiens	124-127
10948064-3	2000	In dogs, the IP procedure (4 cycles of 5-minute occlusion of coronary artery) and exposure to 12, 13-phorbol myristate acetate (PMA) each activated myocardial ecto-5"-nucleotidase and Lck tyrosine kinase.	Tetradecanoylphorbol Acetate	128-131	LCK proto-oncogene, Src family tyrosine kinase	Canis lupus familiaris	184-187
10969784-9	2000	However, treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate induced tumors in 18 and 35% of grafts containing EGF-R null or EGF-R-positive cells, respectively.	Tetradecanoylphorbol Acetate	43-79	epidermal growth factor receptor	Homo sapiens	130-135
10985305-4	2000	Stimulation of these cells with anti-CD28 antibody, and either phorbol 12-myristate 13-acetate (PMA) or anti-CD3, activates signal transduction pathways and results in IL-2 production and IL-2 receptor alpha-chain (CD25) expression.	Tetradecanoylphorbol Acetate	63-94	interleukin 2	Homo sapiens	168-172
10985305-4	2000	Stimulation of these cells with anti-CD28 antibody, and either phorbol 12-myristate 13-acetate (PMA) or anti-CD3, activates signal transduction pathways and results in IL-2 production and IL-2 receptor alpha-chain (CD25) expression.	Tetradecanoylphorbol Acetate	63-94	interleukin 2	Homo sapiens	188-192
10985305-4	2000	Stimulation of these cells with anti-CD28 antibody, and either phorbol 12-myristate 13-acetate (PMA) or anti-CD3, activates signal transduction pathways and results in IL-2 production and IL-2 receptor alpha-chain (CD25) expression.	Tetradecanoylphorbol Acetate	96-99	interleukin 2	Homo sapiens	168-172
10985305-4	2000	Stimulation of these cells with anti-CD28 antibody, and either phorbol 12-myristate 13-acetate (PMA) or anti-CD3, activates signal transduction pathways and results in IL-2 production and IL-2 receptor alpha-chain (CD25) expression.	Tetradecanoylphorbol Acetate	96-99	interleukin 2	Homo sapiens	188-192
10874135-7	2000	A tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), significantly increased the iNOS promoter-dependent reporter gene activity, and the TPA-induced increase in iNOS promoter activity was effectively suppressed by parthenolide, with an IC(50) of approximately 2 microM.	Tetradecanoylphorbol Acetate	33-69	nitric oxide synthase 2	Homo sapiens	105-109
10874135-7	2000	A tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), significantly increased the iNOS promoter-dependent reporter gene activity, and the TPA-induced increase in iNOS promoter activity was effectively suppressed by parthenolide, with an IC(50) of approximately 2 microM.	Tetradecanoylphorbol Acetate	33-69	nitric oxide synthase 2	Homo sapiens	185-189
10874135-7	2000	A tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), significantly increased the iNOS promoter-dependent reporter gene activity, and the TPA-induced increase in iNOS promoter activity was effectively suppressed by parthenolide, with an IC(50) of approximately 2 microM.	Tetradecanoylphorbol Acetate	71-74	nitric oxide synthase 2	Homo sapiens	105-109
10874135-7	2000	A tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), significantly increased the iNOS promoter-dependent reporter gene activity, and the TPA-induced increase in iNOS promoter activity was effectively suppressed by parthenolide, with an IC(50) of approximately 2 microM.	Tetradecanoylphorbol Acetate	71-74	nitric oxide synthase 2	Homo sapiens	185-189
10874135-7	2000	A tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), significantly increased the iNOS promoter-dependent reporter gene activity, and the TPA-induced increase in iNOS promoter activity was effectively suppressed by parthenolide, with an IC(50) of approximately 2 microM.	Tetradecanoylphorbol Acetate	161-164	nitric oxide synthase 2	Homo sapiens	185-189
10969784-9	2000	However, treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate induced tumors in 18 and 35% of grafts containing EGF-R null or EGF-R-positive cells, respectively.	Tetradecanoylphorbol Acetate	43-79	epidermal growth factor receptor	Homo sapiens	144-149
10936484-8	2000	AGN 4204 increased PMA-induced tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) expression, whereas all PPAR ligands showed no effect.	Tetradecanoylphorbol Acetate	19-22	TIMP metallopeptidase inhibitor 1	Homo sapiens	31-78
10936484-8	2000	AGN 4204 increased PMA-induced tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) expression, whereas all PPAR ligands showed no effect.	Tetradecanoylphorbol Acetate	19-22	TIMP metallopeptidase inhibitor 1	Homo sapiens	80-86
10951587-2	2000	The present studies demonstrate that TPA treatment of U-937 leukemia cells is associated with release of mitochondrial cytochrome c, activation of caspase-3 and induction of internucleosomal DNA fragmentation.	Tetradecanoylphorbol Acetate	37-40	cytochrome c, somatic	Homo sapiens	119-131
10911375-9	2000	In vitro studies of the proband"s purified fibrinogen revealed markedly abnormal thrombin-catalyzed polymerization and delayed fibrin clot lysis by tPA-activated plasmin.	Tetradecanoylphorbol Acetate	148-151	fibrinogen beta chain	Homo sapiens	43-53
10951587-2	2000	The present studies demonstrate that TPA treatment of U-937 leukemia cells is associated with release of mitochondrial cytochrome c, activation of caspase-3 and induction of internucleosomal DNA fragmentation.	Tetradecanoylphorbol Acetate	37-40	caspase 3	Homo sapiens	147-156
10951587-4	2000	Moreover, stable overexpression of PKCbeta in TUR cells reconstituted sensitivity to TPA-induced cytochrome c release and activation of caspase-3.	Tetradecanoylphorbol Acetate	85-88	cytochrome c, somatic	Homo sapiens	97-109
10951587-4	2000	Moreover, stable overexpression of PKCbeta in TUR cells reconstituted sensitivity to TPA-induced cytochrome c release and activation of caspase-3.	Tetradecanoylphorbol Acetate	85-88	caspase 3	Homo sapiens	136-145
10951587-7	2000	These findings demonstrate that TPA induces cytochrome c release by a PKCbeta-dependent mechanism and that activation of caspase-mediated signaling is required for induction of the differentiated monocytic phenotype.	Tetradecanoylphorbol Acetate	32-35	cytochrome c, somatic	Homo sapiens	44-56
10816578-9	2000	The effect of calcium on the involucrin promoter was enhanced synergistically by phorbol 12-myristate 13-acetate (PMA) in a protein kinase-dependent manner.	Tetradecanoylphorbol Acetate	81-112	involucrin	Homo sapiens	29-39
10816578-9	2000	The effect of calcium on the involucrin promoter was enhanced synergistically by phorbol 12-myristate 13-acetate (PMA) in a protein kinase-dependent manner.	Tetradecanoylphorbol Acetate	114-117	involucrin	Homo sapiens	29-39
10924082-6	2000	However, stimulation of platelets with thrombin and of PMN with phorbol 12-myristate 13-acetate induced a time-dependent release of VEGF, peaking after 30 and 60 min, respectively.	Tetradecanoylphorbol Acetate	64-95	vascular endothelial growth factor A	Homo sapiens	132-136
10924071-4	2000	In addition, we examined whether PMA affects interleukin-1beta (IL-1beta) stimulation of COX-2 and PGE(2) production.	Tetradecanoylphorbol Acetate	33-36	interleukin 1 beta	Homo sapiens	64-72
10924071-4	2000	In addition, we examined whether PMA affects interleukin-1beta (IL-1beta) stimulation of COX-2 and PGE(2) production.	Tetradecanoylphorbol Acetate	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	89-94
10926560-3	2000	An inhibitor of the dual-specificity ERK kinase (MEK), PD-98059, completely abolished PMA-induced ERK activation.	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase 1	Homo sapiens	37-40
10926560-3	2000	An inhibitor of the dual-specificity ERK kinase (MEK), PD-98059, completely abolished PMA-induced ERK activation.	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase kinase 7	Homo sapiens	49-52
10926560-3	2000	An inhibitor of the dual-specificity ERK kinase (MEK), PD-98059, completely abolished PMA-induced ERK activation.	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase 1	Homo sapiens	98-101
10924071-6	2000	PMA increased COX-2 protein levels 2.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
10930293-9	2000	These observations demonstrate that, C/EBPbeta and c-Jun contribute to the regulation of the TNF-alpha gene in normal macrophages following treatment with PMA.	Tetradecanoylphorbol Acetate	155-158	tumor necrosis factor	Homo sapiens	93-102
10924071-8	2000	Inhibition of either p38 kinase or protein kinase C (PKC) prevented PMA-stimulated COX-2.	Tetradecanoylphorbol Acetate	68-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88
10924071-13	2000	These findings indicate that: 1) PMA, acting through PKC and p38 kinase, enhances COX-2 expression, but chronic treatment with PMA partially inhibits IL-1beta stimulation of COX-2; and 2) exogenous PGF(2alpha) is involved in neonatal ventricular myocyte growth but endogenous COX-2 products are not.	Tetradecanoylphorbol Acetate	33-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
11041200-3	2000	In the present study, we showed that inhibition of protein phosphatases (PP-1 and PP-2a) prevented the TPA-induced differentiation in ML-1 cells.	Tetradecanoylphorbol Acetate	103-106	inorganic pyrophosphatase 1	Homo sapiens	73-77
11041200-4	2000	Preinhibition of PP-1 and PP-2a activities with 1-100 nM okadaic acid dose-dependently blunted the decrease in the phosphorylation status of pRb obtained with TPA and overrode cell cycle arrest.	Tetradecanoylphorbol Acetate	159-162	inorganic pyrophosphatase 1	Homo sapiens	17-21
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	45-74	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
10928984-6	2000	Coincubation with OPC cell lines with conditioned medium from a TPA-exposed HL-60 cells stimulated growth proportional to the IL-6 levels measured in the conditioned medium.	Tetradecanoylphorbol Acetate	64-67	interleukin 6	Homo sapiens	126-130
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	45-74	C-X-C motif chemokine ligand 8	Homo sapiens	250-254
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	250-254
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	172-175	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	172-175	C-X-C motif chemokine ligand 8	Homo sapiens	250-254
10947068-6	2000	Furthermore, inhibition of TNF-alpha/beta and IL-1alpha/beta, together with CD40 ligand, failed to inhibit EC activation by resting T cells and only inhibited the response to PMA- and ionomycin-activated T cells by 40 +/- 18%.	Tetradecanoylphorbol Acetate	175-178	tumor necrosis factor	Homo sapiens	27-36
10981515-3	2000	Present study aims to investigate whether neutrophils primed by 4beta-phorbol 12beta-myristate 13alpha-acetate (PMA) affect the productions of H2O2 and lipid peroxide (LPO), NF-kappaB activation and cytokine production in pancreatic acinar cells, and whether these alterations were inhibited by N-acetylcysteine (NAC) and superoxide dismutase (SOD).	Tetradecanoylphorbol Acetate	112-115	nuclear factor kappa B subunit 1	Homo sapiens	174-183
10981515-3	2000	Present study aims to investigate whether neutrophils primed by 4beta-phorbol 12beta-myristate 13alpha-acetate (PMA) affect the productions of H2O2 and lipid peroxide (LPO), NF-kappaB activation and cytokine production in pancreatic acinar cells, and whether these alterations were inhibited by N-acetylcysteine (NAC) and superoxide dismutase (SOD).	Tetradecanoylphorbol Acetate	112-115	superoxide dismutase 1	Homo sapiens	322-342
10981515-3	2000	Present study aims to investigate whether neutrophils primed by 4beta-phorbol 12beta-myristate 13alpha-acetate (PMA) affect the productions of H2O2 and lipid peroxide (LPO), NF-kappaB activation and cytokine production in pancreatic acinar cells, and whether these alterations were inhibited by N-acetylcysteine (NAC) and superoxide dismutase (SOD).	Tetradecanoylphorbol Acetate	112-115	superoxide dismutase 1	Homo sapiens	344-347
10929069-1	2000	A deficiency of neonatal T lymphocytes to express CD154 antigen in response to ionomycin and phorbol 12-myrsistate 13-acetate (PMA) stimulation or after CD3 cross-linking has been described.	Tetradecanoylphorbol Acetate	127-130	CD40 ligand	Homo sapiens	50-55
10900173-9	2000	A variety of inhibitors which act at different levels of the mitochondrial electron transport chain (rotenone, theonyltrifluoroacetone, antimycin A, cyanide) also inhibited activation of the ERK MAPKs by hydrogen peroxide but not TPA or hyperosmotic shock.	Tetradecanoylphorbol Acetate	230-233	mitogen-activated protein kinase 1	Homo sapiens	191-194
10947075-1	2000	We have treated Jurkat T lymphocytes with a concentration (160 nM) of phorbol myristyl acetate (PMA) that down-regulates conventional and novel protein kinase C (PKC) isozymes and we have investigated the effects on Ca2+ signaling and protein tyrosine phosphorylation using mAb (C305) directed against the beta-subunit of the Ti heterodimer or the epsilon/delta-component of the CD3 complex (mAb Leu 4 or OKT 3).	Tetradecanoylphorbol Acetate	96-99	protein kinase C alpha	Homo sapiens	162-165
10947075-2	2000	The levels of expression of PKC alpha, betaI, betaII, and delta were reduced by 90% or more in PMA-treated cells, whereas the expression of PKCtheta decreased by approximately 30%.	Tetradecanoylphorbol Acetate	95-98	protein kinase C alpha	Homo sapiens	28-37
10954916-7	2000	NF-kappaB activation induced by serum-activated lipopolysaccharide (SALPS), ceramide, and okadaic acid was also inhibited by overexpression of Bcl-x(L), whereas that by phorbol myristate acetate (PMA) and H2O2 was unaffected.	Tetradecanoylphorbol Acetate	169-194	nuclear factor kappa B subunit 1	Homo sapiens	0-9
10954916-7	2000	NF-kappaB activation induced by serum-activated lipopolysaccharide (SALPS), ceramide, and okadaic acid was also inhibited by overexpression of Bcl-x(L), whereas that by phorbol myristate acetate (PMA) and H2O2 was unaffected.	Tetradecanoylphorbol Acetate	196-199	nuclear factor kappa B subunit 1	Homo sapiens	0-9
10954916-7	2000	NF-kappaB activation induced by serum-activated lipopolysaccharide (SALPS), ceramide, and okadaic acid was also inhibited by overexpression of Bcl-x(L), whereas that by phorbol myristate acetate (PMA) and H2O2 was unaffected.	Tetradecanoylphorbol Acetate	196-199	BCL2 like 1	Homo sapiens	143-151
10989184-2	2000	A clear reduction of phorbol myristate acetate (PMA)-induced expression of TNF-alpha mRNA was observed in cells incubated with PRRS virus.	Tetradecanoylphorbol Acetate	21-46	tumor necrosis factor	Homo sapiens	75-84
10947162-2	2000	Protein kinase C inhibitors prevent TNF release in response to LPSa and direct protein kinase C activation with phorbol myristate acetate (PMA) restores TNF secretion after LPSp.	Tetradecanoylphorbol Acetate	112-137	tumor necrosis factor	Mus musculus	153-156
10947162-2	2000	Protein kinase C inhibitors prevent TNF release in response to LPSa and direct protein kinase C activation with phorbol myristate acetate (PMA) restores TNF secretion after LPSp.	Tetradecanoylphorbol Acetate	139-142	tumor necrosis factor	Mus musculus	153-156
10947162-8	2000	Protein kinase C activation with PMA or indolactam restored ERK 1/2 activation and TNF secretion.	Tetradecanoylphorbol Acetate	33-36	tumor necrosis factor	Mus musculus	83-86
10989184-2	2000	A clear reduction of phorbol myristate acetate (PMA)-induced expression of TNF-alpha mRNA was observed in cells incubated with PRRS virus.	Tetradecanoylphorbol Acetate	48-51	tumor necrosis factor	Homo sapiens	75-84
10887141-5	2000	Fibroblasts grown from synovial and peritoneal tissues displayed C5a/IL-8-inhibitor activity that could be further induced with phorbol myristate acetate (PMA) and IL-1 beta.	Tetradecanoylphorbol Acetate	128-153	complement C5a receptor 1	Homo sapiens	65-68
10807930-0	2000	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity.	Tetradecanoylphorbol Acetate	0-36	mitogen-activated protein kinase 8	Homo sapiens	51-74
10807930-0	2000	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity.	Tetradecanoylphorbol Acetate	0-36	mitogen-activated protein kinase 8	Homo sapiens	76-79
10807930-0	2000	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity.	Tetradecanoylphorbol Acetate	0-36	mitogen-activated protein kinase 8	Homo sapiens	174-177
10807930-0	2000	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase 8	Homo sapiens	51-74
10807930-0	2000	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase 8	Homo sapiens	76-79
10807930-0	2000	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase 8	Homo sapiens	174-177
10807930-0	2000	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity.	Tetradecanoylphorbol Acetate	160-163	mitogen-activated protein kinase 8	Homo sapiens	76-79
10807930-2	2000	JNK can be activated by the tumor promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA) in normal human oral keratinocytes but not in human keratinocytes that have been immortalized (HOK-16B and HaCaT) or transformed (HOK-16B-Bap-T) nor in a cervical carcinoma cell line (HeLa).	Tetradecanoylphorbol Acetate	51-87	mitogen-activated protein kinase 8	Homo sapiens	0-3
10807930-2	2000	JNK can be activated by the tumor promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA) in normal human oral keratinocytes but not in human keratinocytes that have been immortalized (HOK-16B and HaCaT) or transformed (HOK-16B-Bap-T) nor in a cervical carcinoma cell line (HeLa).	Tetradecanoylphorbol Acetate	89-92	mitogen-activated protein kinase 8	Homo sapiens	0-3
10807930-3	2000	The refractory JNK activation response to TPA is not due a defect in the JNK pathway, because JNK can be activated by other stimuli, e.g. UV irradiation and an alkylating agent N-methyl-N"-nitrosoguanidine in these immortalized or transformed cells.	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 8	Homo sapiens	15-18
10807930-4	2000	More importantly, the refractory JNK and JNKK activation response to TPA can be restored by treatment of the cells with a combination of TPA and a protein-tyrosine phosphatase inhibitor, sodium orthovanadate.	Tetradecanoylphorbol Acetate	69-72	mitogen-activated protein kinase 8	Homo sapiens	33-36
10807930-4	2000	More importantly, the refractory JNK and JNKK activation response to TPA can be restored by treatment of the cells with a combination of TPA and a protein-tyrosine phosphatase inhibitor, sodium orthovanadate.	Tetradecanoylphorbol Acetate	69-72	mitogen-activated protein kinase kinase 4	Homo sapiens	41-45
10807930-4	2000	More importantly, the refractory JNK and JNKK activation response to TPA can be restored by treatment of the cells with a combination of TPA and a protein-tyrosine phosphatase inhibitor, sodium orthovanadate.	Tetradecanoylphorbol Acetate	137-140	mitogen-activated protein kinase 8	Homo sapiens	33-36
10807930-4	2000	More importantly, the refractory JNK and JNKK activation response to TPA can be restored by treatment of the cells with a combination of TPA and a protein-tyrosine phosphatase inhibitor, sodium orthovanadate.	Tetradecanoylphorbol Acetate	137-140	mitogen-activated protein kinase kinase 4	Homo sapiens	41-45
10807930-5	2000	Furthermore, pretreatment of cells with TPA partially inhibited UV- or N-methyl-N"-nitrosoguanidine-induced JNK activity.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 8	Homo sapiens	108-111
10807930-6	2000	These results suggest that a TPA-inducible, orthovanadate-sensitive protein-tyrosine phosphatase may specifically down-regulate JNK signaling pathway in these immortalized/transformed epithelial cells.	Tetradecanoylphorbol Acetate	29-32	mitogen-activated protein kinase 8	Homo sapiens	128-131
10783385-8	2000	However, treatment with a phorbol ester, phorbol 12-myristate 13-acetate, enhanced ACE secretion even from cells overexpressing BiP.	Tetradecanoylphorbol Acetate	41-72	angiotensin I converting enzyme	Homo sapiens	83-86
10783385-8	2000	However, treatment with a phorbol ester, phorbol 12-myristate 13-acetate, enhanced ACE secretion even from cells overexpressing BiP.	Tetradecanoylphorbol Acetate	41-72	heat shock protein family A (Hsp70) member 5	Homo sapiens	128-131
10783385-10	2000	Treatment with phorbol 12-myristate 13-acetate caused marked reduction in ACE association of selective PKC species.	Tetradecanoylphorbol Acetate	15-46	angiotensin I converting enzyme	Homo sapiens	74-77
10922477-1	2000	Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130.	Tetradecanoylphorbol Acetate	90-93	interleukin 6	Homo sapiens	123-141
10922477-1	2000	Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130.	Tetradecanoylphorbol Acetate	90-93	interleukin 6	Homo sapiens	396-400
10922477-2	2000	In this study, we demonstrate that PMA inhibits STAT activation by IL-6 and the related cytokine leukemia inhibitory factor (LIF) but not by oncostatin M (OSM).	Tetradecanoylphorbol Acetate	35-38	interleukin 6	Homo sapiens	67-71
10908728-0	2000	Annexin-I inhibits PMA-induced c-fos SRE activation by suppressing cytosolic phospholipase A2 signal.	Tetradecanoylphorbol Acetate	19-22	annexin A1	Rattus norvegicus	0-9
10777489-4	2000	Inhibitors of extracellular signal-regulated kinase (ERK) activation blocked TPA-induced MCL1 phosphorylation but not the taxol-induced band shift.	Tetradecanoylphorbol Acetate	77-80	mitogen-activated protein kinase 1	Homo sapiens	14-51
10777489-4	2000	Inhibitors of extracellular signal-regulated kinase (ERK) activation blocked TPA-induced MCL1 phosphorylation but not the taxol-induced band shift.	Tetradecanoylphorbol Acetate	77-80	mitogen-activated protein kinase 1	Homo sapiens	53-56
10887141-5	2000	Fibroblasts grown from synovial and peritoneal tissues displayed C5a/IL-8-inhibitor activity that could be further induced with phorbol myristate acetate (PMA) and IL-1 beta.	Tetradecanoylphorbol Acetate	128-153	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
10777489-7	2000	Thus, MCL1 undergoes two distinct types of phosphorylation: (i) TPA-induced, ERK-associated phosphorylation, which does not alter the electrophoretic mobility of MCL1, and (ii) ERK-independent phosphorylation, which results in an MCL1 band shift and is induced by events in G(2)/M or protein phosphatase 1/2A inhibitors.	Tetradecanoylphorbol Acetate	64-67	mitogen-activated protein kinase 1	Homo sapiens	77-80
10887141-5	2000	Fibroblasts grown from synovial and peritoneal tissues displayed C5a/IL-8-inhibitor activity that could be further induced with phorbol myristate acetate (PMA) and IL-1 beta.	Tetradecanoylphorbol Acetate	155-158	complement C5a receptor 1	Homo sapiens	65-68
10887141-5	2000	Fibroblasts grown from synovial and peritoneal tissues displayed C5a/IL-8-inhibitor activity that could be further induced with phorbol myristate acetate (PMA) and IL-1 beta.	Tetradecanoylphorbol Acetate	155-158	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
10912793-3	2000	PMA but not phenylephrine rapidly activated PKCalpha in TFG2 cells, and the highly selective PKC inhibitor bisindolylmaleimide (GFX) completely abolished PMA-induced but not PE-induced scattering.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	44-52
10912793-3	2000	PMA but not phenylephrine rapidly activated PKCalpha in TFG2 cells, and the highly selective PKC inhibitor bisindolylmaleimide (GFX) completely abolished PMA-induced but not PE-induced scattering.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	44-47
10873632-6	2000	mRNAs of both PGE-specific receptors and peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear receptor superfamily of ligand-dependent transcription factors, were expressed in phorbol 12-myristate 13-acetate-differentiated U937, a human macrophage model (H-Mac).	Tetradecanoylphorbol Acetate	209-240	peroxisome proliferator activated receptor gamma	Homo sapiens	41-89
10873632-6	2000	mRNAs of both PGE-specific receptors and peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear receptor superfamily of ligand-dependent transcription factors, were expressed in phorbol 12-myristate 13-acetate-differentiated U937, a human macrophage model (H-Mac).	Tetradecanoylphorbol Acetate	209-240	peroxisome proliferator activated receptor gamma	Homo sapiens	91-100
10899038-7	2000	cis-UFA also interacted synergistically with the PKC activator phorbol 12-myristate 13-acetate to promote positive inotropic responses.	Tetradecanoylphorbol Acetate	63-94	protein kinase C alpha	Homo sapiens	49-52
10953336-0	2000	Differential TPA and PDGF-BB effects on subcellular localisation of PKC alpha and beta I in C3H/10T1/2 cells.	Tetradecanoylphorbol Acetate	13-16	protein kinase C, alpha	Mus musculus	68-77
10953336-5	2000	12-O-tetradecanoyl phorbol-13-acetate (TPA) caused translocation of cytoplasmic PKC alpha and beta I to the nucleus/nuclear associated endoplasmatic reticulum fraction.	Tetradecanoylphorbol Acetate	0-37	protein kinase C, alpha	Mus musculus	80-89
10953336-5	2000	12-O-tetradecanoyl phorbol-13-acetate (TPA) caused translocation of cytoplasmic PKC alpha and beta I to the nucleus/nuclear associated endoplasmatic reticulum fraction.	Tetradecanoylphorbol Acetate	39-42	protein kinase C, alpha	Mus musculus	80-89
10891386-7	2000	Ang II-induced ERK activation was inhibited by protein kinase C (PKC)-specific inhibitor GF109203X, while TRO was also able to block PKC activator phorbol 12 myristate 13-acetate (PMA)-induced ERK activation.	Tetradecanoylphorbol Acetate	147-178	angiotensinogen	Homo sapiens	0-6
10953336-6	2000	Down-regulation of PKC and bisindolylmaleimide I inhibited both TPA and PDGF-BB stimulated Erk1 activity.	Tetradecanoylphorbol Acetate	64-67	protein kinase C, alpha	Mus musculus	19-22
10891386-7	2000	Ang II-induced ERK activation was inhibited by protein kinase C (PKC)-specific inhibitor GF109203X, while TRO was also able to block PKC activator phorbol 12 myristate 13-acetate (PMA)-induced ERK activation.	Tetradecanoylphorbol Acetate	147-178	mitogen-activated protein kinase 1	Homo sapiens	193-196
10919360-0	2000	Inducible nitric oxide synthase mRNA is upregulated in skin tumors of v-ha-ras transgenic TG-AC mice treated with 12-o-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	114-150	nitric oxide synthase 2, inducible	Mus musculus	0-31
10891386-7	2000	Ang II-induced ERK activation was inhibited by protein kinase C (PKC)-specific inhibitor GF109203X, while TRO was also able to block PKC activator phorbol 12 myristate 13-acetate (PMA)-induced ERK activation.	Tetradecanoylphorbol Acetate	180-183	angiotensinogen	Homo sapiens	0-6
10919360-1	2000	The correlation between the steady-state level of inducible nitric oxide synthase (iNOS) mRNA and skin tumors induced following treatment with 12-o-tetradecanoylphorbol-13-acetate (TPA) was investigated in transgenic TG-AC mice, which carry the v-Ha-ras oncogene fused to the promoter of the mouse embryonic alpha-like, zeta-globin gene.	Tetradecanoylphorbol Acetate	143-179	nitric oxide synthase 2, inducible	Mus musculus	50-81
10919360-1	2000	The correlation between the steady-state level of inducible nitric oxide synthase (iNOS) mRNA and skin tumors induced following treatment with 12-o-tetradecanoylphorbol-13-acetate (TPA) was investigated in transgenic TG-AC mice, which carry the v-Ha-ras oncogene fused to the promoter of the mouse embryonic alpha-like, zeta-globin gene.	Tetradecanoylphorbol Acetate	143-179	nitric oxide synthase 2, inducible	Mus musculus	83-87
10919360-1	2000	The correlation between the steady-state level of inducible nitric oxide synthase (iNOS) mRNA and skin tumors induced following treatment with 12-o-tetradecanoylphorbol-13-acetate (TPA) was investigated in transgenic TG-AC mice, which carry the v-Ha-ras oncogene fused to the promoter of the mouse embryonic alpha-like, zeta-globin gene.	Tetradecanoylphorbol Acetate	181-184	nitric oxide synthase 2, inducible	Mus musculus	50-81
10919360-1	2000	The correlation between the steady-state level of inducible nitric oxide synthase (iNOS) mRNA and skin tumors induced following treatment with 12-o-tetradecanoylphorbol-13-acetate (TPA) was investigated in transgenic TG-AC mice, which carry the v-Ha-ras oncogene fused to the promoter of the mouse embryonic alpha-like, zeta-globin gene.	Tetradecanoylphorbol Acetate	181-184	nitric oxide synthase 2, inducible	Mus musculus	83-87
10919360-2	2000	In animals treated with TPA (2.5 microg x 2/week, for 2 weeks), the increase of iNOS mRNA was locally confined only to the regions of papillomas, but not to the skin tissues surrounding the papillomas.	Tetradecanoylphorbol Acetate	24-27	nitric oxide synthase 2, inducible	Mus musculus	80-84
10919360-4	2000	These data suggest that iNOS gene expressions may underlie tumorigenesis during TPA promotion in TG-AC mice.	Tetradecanoylphorbol Acetate	80-83	nitric oxide synthase 2, inducible	Mus musculus	24-28
10886243-7	2000	In accordance with this, CD80 and phorbol myristate acetate (PMA) (without anti-CD3 or calcium ionophore) were sufficient to induce production of IL-5 and IL-13, but not of IL-4.	Tetradecanoylphorbol Acetate	34-59	interleukin 13	Homo sapiens	155-160
10886243-7	2000	In accordance with this, CD80 and phorbol myristate acetate (PMA) (without anti-CD3 or calcium ionophore) were sufficient to induce production of IL-5 and IL-13, but not of IL-4.	Tetradecanoylphorbol Acetate	61-64	interleukin 13	Homo sapiens	155-160
10880263-5	2000	Phorbol-12-myristate-13-acetate (PMA), calcium ionophore A23187, TNF-alpha, IL-1beta, oncostatin M (OSM) but not lipopolysaccharide stimulated IL-6 production from gastric epithelial cell line MKN-28.	Tetradecanoylphorbol Acetate	0-31	interleukin 6	Homo sapiens	143-147
10861271-8	2000	Basal migration and the motogenic effects of butyrate, epidermal growth factor, and phorbol-12-myristate-13-acetate were suppressed by the u-PAR antisense oligonucleotide (40-60%) but were at best minimally affected following inhibition of u-PA expression and binding.	Tetradecanoylphorbol Acetate	84-115	plasminogen activator, urokinase	Homo sapiens	139-143
10880263-8	2000	Protein kinase (PK) C inhibitor only reduced the PMA and OSM induced IL-6 production.	Tetradecanoylphorbol Acetate	49-52	proline rich transmembrane protein 2	Homo sapiens	0-21
10848585-3	2000	Of the six PKC isoforms that were present in glioma cells, PKC alpha was both necessary and sufficient to promote cell cycle progression when stimulated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	158-189	protein kinase C alpha	Homo sapiens	11-14
11002391-5	2000	Phenotyping of U937 cells for complement receptors (CRs) and Fcgamma receptors (FcgammaRs) showed that interferon gamma (INFgamma) increased expression of FcgammaRI, CR3 (CD11b/CD18) and CR4 (CD11c/CD18) and that phorbol-12-myristate-13-acetate (PMA) increased expression of CR4.	Tetradecanoylphorbol Acetate	213-244	interferon gamma	Homo sapiens	103-130
10862715-3	2000	It is demonstrated here that acute TPA exposure induces the transport of activated PKC(alpha) from the plasma membrane to endosomes.	Tetradecanoylphorbol Acetate	35-38	protein kinase C alpha	Homo sapiens	83-93
11007162-4	2000	RESULTS: Activation of lymphocytes with PMA + Ionomycin induced the expression of IL-2 and IFN-gamma in each lymphocyte population.	Tetradecanoylphorbol Acetate	40-43	interleukin 2	Homo sapiens	82-86
11007162-4	2000	RESULTS: Activation of lymphocytes with PMA + Ionomycin induced the expression of IL-2 and IFN-gamma in each lymphocyte population.	Tetradecanoylphorbol Acetate	40-43	interferon gamma	Homo sapiens	91-100
10874007-10	2000	Conditioned medium isolated from TPA-treated MCF10A-NeoT cultures also suppressed MCF10A-NeoT proliferation for approximately 72 h, but suppressed MCF10A-Neo proliferation for &lt;24 h. These studies suggest that TPA quickly activates proteolytic processes in MCF10A-Neo cells leading to the activation of latent TGF beta supplied by the serum in the culture medium.	Tetradecanoylphorbol Acetate	33-36	transforming growth factor beta 1	Homo sapiens	313-321
10874007-10	2000	Conditioned medium isolated from TPA-treated MCF10A-NeoT cultures also suppressed MCF10A-NeoT proliferation for approximately 72 h, but suppressed MCF10A-Neo proliferation for &lt;24 h. These studies suggest that TPA quickly activates proteolytic processes in MCF10A-Neo cells leading to the activation of latent TGF beta supplied by the serum in the culture medium.	Tetradecanoylphorbol Acetate	213-216	transforming growth factor beta 1	Homo sapiens	313-321
10860921-6	2000	Thus, in K562 cells, 12-O-tetradecanoylphorbol-13-acetate-inducible expression of P-glycoprotein, the product of MDR1 gene, was strongly and selectively inhibited by the presence of a repressor protein targeted to the MDR1 promoter.	Tetradecanoylphorbol Acetate	21-57	ATP binding cassette subfamily B member 1	Homo sapiens	82-96
10860921-6	2000	Thus, in K562 cells, 12-O-tetradecanoylphorbol-13-acetate-inducible expression of P-glycoprotein, the product of MDR1 gene, was strongly and selectively inhibited by the presence of a repressor protein targeted to the MDR1 promoter.	Tetradecanoylphorbol Acetate	21-57	ATP binding cassette subfamily B member 1	Homo sapiens	113-117
10860921-6	2000	Thus, in K562 cells, 12-O-tetradecanoylphorbol-13-acetate-inducible expression of P-glycoprotein, the product of MDR1 gene, was strongly and selectively inhibited by the presence of a repressor protein targeted to the MDR1 promoter.	Tetradecanoylphorbol Acetate	21-57	ATP binding cassette subfamily B member 1	Homo sapiens	218-222
10848585-3	2000	Of the six PKC isoforms that were present in glioma cells, PKC alpha was both necessary and sufficient to promote cell cycle progression when stimulated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	158-189	protein kinase C alpha	Homo sapiens	59-68
10871841-0	2000	Annexin V inhibits the 12-O-tetradecanoylphorbol-13-acetate-induced activation of Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of Shc in MCF-7 cells.	Tetradecanoylphorbol Acetate	23-59	mitogen-activated protein kinase 1	Homo sapiens	125-128
10940203-6	2000	Interleukin (IL)-1 and phorbol 12-myristate 13-acetate (PMA) induced shedding of TNFRI from ED27 and primary cells suggesting that under inflammatory conditions the soluble receptor protein may protect from cytotoxic effects of TNF-alpha.	Tetradecanoylphorbol Acetate	23-54	tumor necrosis factor	Homo sapiens	228-237
10940203-6	2000	Interleukin (IL)-1 and phorbol 12-myristate 13-acetate (PMA) induced shedding of TNFRI from ED27 and primary cells suggesting that under inflammatory conditions the soluble receptor protein may protect from cytotoxic effects of TNF-alpha.	Tetradecanoylphorbol Acetate	56-59	tumor necrosis factor	Homo sapiens	228-237
10926117-2	2000	When the cells were pretreated for 24 h with phorbol myristate acetate to down-regulate protein kinase C (PKC), PLD stimulation by Der p I was largely abolished.	Tetradecanoylphorbol Acetate	45-70	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	112-115
10764798-1	2000	Mitogen-activated protein (MAP) kinases stimulated by phorbol 13-myristate 12-acetate (PMA) have been shown to inhibit interleukin-6-induced activation of STAT3 (Sengupta, T. K., Talbot, E. S., Scherle, P. A., and Ivashkiv, L. B.	Tetradecanoylphorbol Acetate	87-90	interleukin 6	Homo sapiens	119-132
10764798-1	2000	Mitogen-activated protein (MAP) kinases stimulated by phorbol 13-myristate 12-acetate (PMA) have been shown to inhibit interleukin-6-induced activation of STAT3 (Sengupta, T. K., Talbot, E. S., Scherle, P. A., and Ivashkiv, L. B.	Tetradecanoylphorbol Acetate	87-90	signal transducer and activator of transcription 3	Homo sapiens	155-160
10842188-11	2000	Since reported data have indicated that plasminogen activators (uPA and tPA) were able to excise the angiostatin fragment from the plasminogen parent molecule via plasmin generation, we determined levels of uPA and tPA and PAI-1 antigen in the conditioned media, and correlated the results with angiostatin-generating capacity.	Tetradecanoylphorbol Acetate	215-218	proline rich acidic protein 1	Homo sapiens	64-67
10866321-5	2000	In a transient transfection assay, all three RAR subtypes, RARalpha, RARbeta, and RARgamma, could effectively inhibit phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity and the activity of oncogenes c-Jun and c-Fos on AP-1 containing reporter genes in the presence of retinoic acid (RA).	Tetradecanoylphorbol Acetate	132-168	retinoic acid receptor beta	Homo sapiens	69-76
10747895-4	2000	Expression of eNOS in transfected U937 cells increased phorbol 12-myristate 13-acetate-induced TNFalpha promoter activity and TNFalpha production.	Tetradecanoylphorbol Acetate	55-86	nitric oxide synthase 3	Homo sapiens	14-18
10747895-4	2000	Expression of eNOS in transfected U937 cells increased phorbol 12-myristate 13-acetate-induced TNFalpha promoter activity and TNFalpha production.	Tetradecanoylphorbol Acetate	55-86	tumor necrosis factor	Homo sapiens	95-103
10866668-6	2000	The hyperplastic response observed in the epidermis after TPA application was significantly greater in the PPARbeta-null mice than in controls.	Tetradecanoylphorbol Acetate	58-61	peroxisome proliferator activator receptor delta	Mus musculus	107-115
10940738-6	2000	VIP and PACAP38 activation of ERK2 was blocked by the protein kinase A inhibitor H89, whereas the protein kinase C inhibitor GF109203X, or prior PMA-induced depletion of the protein kinases C, failed to inhibit VIP and PACAP38 activation of ERK2.	Tetradecanoylphorbol Acetate	145-148	vasoactive intestinal peptide	Rattus norvegicus	0-3
10867029-7	2000	However, although ERK inhibition did not affect A23187-induced arachidonic acid release, it suppressed zymosan-, PMA-, and okadaic acid-induced arachidonic acid release under conditions where phosphorylation of cPLA(2) on Ser-505 was unaffected.	Tetradecanoylphorbol Acetate	113-116	mitogen-activated protein kinase 1	Mus musculus	18-21
10871841-12	2000	PD98059 inhibited this increase, suggesting that TPA upregulation of p21WAF/CIP1 occurs via the MEK pathway, and that annexin V overexpression blunts it.	Tetradecanoylphorbol Acetate	49-52	cyclin dependent kinase inhibitor 1A	Homo sapiens	76-80
10871841-12	2000	PD98059 inhibited this increase, suggesting that TPA upregulation of p21WAF/CIP1 occurs via the MEK pathway, and that annexin V overexpression blunts it.	Tetradecanoylphorbol Acetate	49-52	mitogen-activated protein kinase kinase 7	Homo sapiens	96-99
10871841-13	2000	This work shows that annexin V overexpression suppresses the TPA-induced Ras/ERK signaling by inhibiting at/or upstream of Shc, possibly through the inhibition of PKCs.	Tetradecanoylphorbol Acetate	61-64	mitogen-activated protein kinase 1	Homo sapiens	77-80
10871841-4	2000	In these cells, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation and kinase activity of ERK1/2 were suppressed.	Tetradecanoylphorbol Acetate	16-52	mitogen-activated protein kinase 3	Homo sapiens	106-112
10871841-4	2000	In these cells, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation and kinase activity of ERK1/2 were suppressed.	Tetradecanoylphorbol Acetate	54-57	mitogen-activated protein kinase 3	Homo sapiens	106-112
10871841-5	2000	Morphological changes induced by TPA were reduced by annexin V overexpression as well as by the pan-PKC inhibitor, bisindolylmaleimide I, and by the mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) inhibitor, PD98059.	Tetradecanoylphorbol Acetate	33-36	mitogen-activated protein kinase kinase 7	Homo sapiens	228-231
10871841-8	2000	TPA treatment of MCF-7 cells caused an increased association of Shc with Grb2.	Tetradecanoylphorbol Acetate	0-3	growth factor receptor bound protein 2	Homo sapiens	73-77
10871841-11	2000	TPA induced the expression of p21WAF/CIP1 to a greater extent in MCF-7 parent and control plasmid cells than in annexin V overexpressors.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	37-41
10819756-6	2000	Treatment of GV oocytes with the biologically active phorbol ester, 12-o-tetradecanoyl phorbol-13-acetate (TPA), resulted in a rapid translocation of the cytosolic PKC-alpha, but not PKC-betaI, PKC-betaII, or RACK1, to the plasma membrane.	Tetradecanoylphorbol Acetate	68-105	protein kinase C, alpha	Mus musculus	164-173
10816429-9	2000	In contrast, phosphatidylinositol 3-kinase (PI 3-kinase) and protein kinase B (PKB) activation by insulin and HGF is strong and sustained, whereas it is weak and transient with EGF and absent in the presence of TSH or PMA.	Tetradecanoylphorbol Acetate	218-221	hepatocyte growth factor	Canis lupus familiaris	110-113
10748182-5	2000	Strikingly, whereas activation of either of these pathways individually did not induce NFAT activity in control cells, in Nef-expressing cells phorbol 12-myristate 13-acetate treatment alone resulted in a 100-fold increase in NFAT-directed gene expression.	Tetradecanoylphorbol Acetate	143-174	S100 calcium binding protein B	Homo sapiens	122-125
10819756-6	2000	Treatment of GV oocytes with the biologically active phorbol ester, 12-o-tetradecanoyl phorbol-13-acetate (TPA), resulted in a rapid translocation of the cytosolic PKC-alpha, but not PKC-betaI, PKC-betaII, or RACK1, to the plasma membrane.	Tetradecanoylphorbol Acetate	107-110	protein kinase C, alpha	Mus musculus	164-173
10819756-9	2000	Treatment with TPA resulted in a rapid translocation of PKC-alpha from the cytoplasm to the plasma membrane and a significant decrease of PKC-betaI throughout the cytoplasm, while it also remained in the cell periphery.	Tetradecanoylphorbol Acetate	15-18	protein kinase C, alpha	Mus musculus	56-65
10834937-4	2000	We show that TPA inhibits the activation of secreted latent TGF-beta, thus decreasing the concentration of active TGF-beta to which the cells are exposed.	Tetradecanoylphorbol Acetate	13-16	transforming growth factor beta 1	Homo sapiens	60-68
10848707-9	2000	The expression of c-Fos was increased by phorbol 12-myristate 13-acetate added before NGF, suggesting that c-Fos may be involved in regulating NGF production.	Tetradecanoylphorbol Acetate	41-72	nerve growth factor	Homo sapiens	143-146
10963042-7	2000	We also determined that the response could be mimicked by combining the effect of 8-bromo-cAMP and 12-O-tetradecanoyl-phorbol-13-acetate, stimulators of the protein kinase A and protein kinase C pathways, respectively, both known to be activated by PTH.	Tetradecanoylphorbol Acetate	99-136	parathyroid hormone	Rattus norvegicus	249-252
10959625-8	2000	Since TPA is capable of stimulating the expression of cyclin D1 not only through TRE but also through CRE and NF-kappaB response element in the promoter, we tentatively propose a sequence of events that possibly leads to TPA-induced, anchorage-independent synthesis of cyclins D1 and A in the promotion-sensitive JB6 mouse epidermal cells.	Tetradecanoylphorbol Acetate	6-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-119
10959625-8	2000	Since TPA is capable of stimulating the expression of cyclin D1 not only through TRE but also through CRE and NF-kappaB response element in the promoter, we tentatively propose a sequence of events that possibly leads to TPA-induced, anchorage-independent synthesis of cyclins D1 and A in the promotion-sensitive JB6 mouse epidermal cells.	Tetradecanoylphorbol Acetate	221-224	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-119
10849009-7	2000	The increase of BZLF1"s activity depends on a single serine residue (S186) that is phosphorylated by protein kinase C (PKC) in vitro and in vivo after stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	168-204	proline rich transmembrane protein 2	Homo sapiens	101-117
10849009-7	2000	The increase of BZLF1"s activity depends on a single serine residue (S186) that is phosphorylated by protein kinase C (PKC) in vitro and in vivo after stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	168-204	proline rich transmembrane protein 2	Homo sapiens	119-122
10849009-7	2000	The increase of BZLF1"s activity depends on a single serine residue (S186) that is phosphorylated by protein kinase C (PKC) in vitro and in vivo after stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	206-209	proline rich transmembrane protein 2	Homo sapiens	101-117
10849009-7	2000	The increase of BZLF1"s activity depends on a single serine residue (S186) that is phosphorylated by protein kinase C (PKC) in vitro and in vivo after stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	206-209	proline rich transmembrane protein 2	Homo sapiens	119-122
10834937-4	2000	We show that TPA inhibits the activation of secreted latent TGF-beta, thus decreasing the concentration of active TGF-beta to which the cells are exposed.	Tetradecanoylphorbol Acetate	13-16	transforming growth factor beta 1	Homo sapiens	114-122
10834937-5	2000	This event is mediated by the TPA-induced alteration of the uPA/PAI serine-protease system.	Tetradecanoylphorbol Acetate	30-33	plasminogen activator, urokinase	Homo sapiens	60-63
10834937-7	2000	In contrast, a reduction in the TGF-beta concentration, to a range of 0.14-0.20 x 10(-2) ng/ml (which is similar to that measured in TPA-treated cells), mimics TPA-induced differentiation.	Tetradecanoylphorbol Acetate	133-136	transforming growth factor beta 1	Homo sapiens	32-40
10834937-7	2000	In contrast, a reduction in the TGF-beta concentration, to a range of 0.14-0.20 x 10(-2) ng/ml (which is similar to that measured in TPA-treated cells), mimics TPA-induced differentiation.	Tetradecanoylphorbol Acetate	160-163	transforming growth factor beta 1	Homo sapiens	32-40
10834937-9	2000	By impairing the TGF-beta autocrine loop, TPA stabilizes the factor concentration within the range compatible for differentiation to occur.	Tetradecanoylphorbol Acetate	42-45	transforming growth factor beta 1	Homo sapiens	17-25
10834937-10	2000	In contrast, in human primary muscle cells a much higher concentration of exogenous TGF-beta is required for the differentiation inhibitory effect and TPA inhibits differentiation in these cells probably through a TGF-beta independent mechanism.	Tetradecanoylphorbol Acetate	151-154	transforming growth factor beta 1	Homo sapiens	214-222
10833264-3	2000	The extent of the oxidation of human low density lipoprotein (LDL) by phorbol myristate acetate (PMA)-activated neutrophils of wild-type and MPO-knockout mice was assessed by measuring consumption of a-tocopherol and formation of phosphatidylcholine hydroperoxide (PCOOH) and cholesteryl ester hydroperoxide (CEOOH).	Tetradecanoylphorbol Acetate	97-100	myeloperoxidase	Homo sapiens	141-144
10886401-4	2000	Synovial T cells could up-regulate their CD154 expression following activation with phorbol 12-myristate 13-acetate (PMA) + ionomycin or anti-CD3 + anti-CD28 monoclonal antibodies (mAbs), but the maximal level of expression remained lower than in control T cells.	Tetradecanoylphorbol Acetate	84-115	CD40 ligand	Homo sapiens	41-46
10886401-4	2000	Synovial T cells could up-regulate their CD154 expression following activation with phorbol 12-myristate 13-acetate (PMA) + ionomycin or anti-CD3 + anti-CD28 monoclonal antibodies (mAbs), but the maximal level of expression remained lower than in control T cells.	Tetradecanoylphorbol Acetate	117-120	CD40 ligand	Homo sapiens	41-46
10825368-5	2000	We cross-linked Qa-2 protein on the surface of C57BL/6 2-cell and 8-cell embryos, in the presence of 4/5-phorbol-12-myristate-13-acetate (PMA), and assessed the percentage of embryos reaching the blastocyst stage, the percentage hatching from the zona pellucida, [(3)H-thymidine] incorporation into DNA, and the total number of cells per embryo as measures of embryonic cleavage rate.	Tetradecanoylphorbol Acetate	105-136	Qa lymphocyte antigen 2 region	Mus musculus	16-20
10825394-1	2000	Previously, we reported that 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced apoptosis of LNCaP human prostate cancer cells was accompanied by prolonged translocation of protein kinase C (PKC)alpha to non-nuclear membranes and that TPA-resistant LNCaP cells had down-regulated PKCalpha.	Tetradecanoylphorbol Acetate	29-65	protein kinase C alpha	Homo sapiens	191-200
10825394-1	2000	Previously, we reported that 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced apoptosis of LNCaP human prostate cancer cells was accompanied by prolonged translocation of protein kinase C (PKC)alpha to non-nuclear membranes and that TPA-resistant LNCaP cells had down-regulated PKCalpha.	Tetradecanoylphorbol Acetate	29-65	protein kinase C alpha	Homo sapiens	280-288
10825394-1	2000	Previously, we reported that 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced apoptosis of LNCaP human prostate cancer cells was accompanied by prolonged translocation of protein kinase C (PKC)alpha to non-nuclear membranes and that TPA-resistant LNCaP cells had down-regulated PKCalpha.	Tetradecanoylphorbol Acetate	67-70	protein kinase C alpha	Homo sapiens	191-200
10781688-7	2000	In HL-60 cells, sorbitol-induced apoptosis was prevented by the treatment of phorbol myristate 13-acetate (PMA), which activates the ERK/MAPK pathway, and this was blocked by PD98059.	Tetradecanoylphorbol Acetate	107-110	mitogen-activated protein kinase 1	Homo sapiens	133-136
10781688-7	2000	In HL-60 cells, sorbitol-induced apoptosis was prevented by the treatment of phorbol myristate 13-acetate (PMA), which activates the ERK/MAPK pathway, and this was blocked by PD98059.	Tetradecanoylphorbol Acetate	107-110	mitogen-activated protein kinase 1	Homo sapiens	137-141
10825394-1	2000	Previously, we reported that 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced apoptosis of LNCaP human prostate cancer cells was accompanied by prolonged translocation of protein kinase C (PKC)alpha to non-nuclear membranes and that TPA-resistant LNCaP cells had down-regulated PKCalpha.	Tetradecanoylphorbol Acetate	67-70	protein kinase C alpha	Homo sapiens	280-288
10825368-5	2000	We cross-linked Qa-2 protein on the surface of C57BL/6 2-cell and 8-cell embryos, in the presence of 4/5-phorbol-12-myristate-13-acetate (PMA), and assessed the percentage of embryos reaching the blastocyst stage, the percentage hatching from the zona pellucida, [(3)H-thymidine] incorporation into DNA, and the total number of cells per embryo as measures of embryonic cleavage rate.	Tetradecanoylphorbol Acetate	138-141	Qa lymphocyte antigen 2 region	Mus musculus	16-20
10825394-1	2000	Previously, we reported that 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced apoptosis of LNCaP human prostate cancer cells was accompanied by prolonged translocation of protein kinase C (PKC)alpha to non-nuclear membranes and that TPA-resistant LNCaP cells had down-regulated PKCalpha.	Tetradecanoylphorbol Acetate	235-238	protein kinase C alpha	Homo sapiens	191-200
10825394-6	2000	Immunoblot analysis revealed that TPA induced prolonged hyperphosphorylation of Raf-1 and activation of extracellular-regulated/mitogen-activated protein kinases 1 and 2 in untransfected LNCaP cells, as did bryostatin 1 in PKCalpha-overexpressing cells.	Tetradecanoylphorbol Acetate	34-37	protein kinase C alpha	Homo sapiens	223-231
11032759-5	2000	We report the isolation of HoxC11 in a yeast one-hybrid screen for factors binding to a phorbol-ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (VLTRE), which is also a target for TPA-induced binding of Rel factors in gel-shift experiments.	Tetradecanoylphorbol Acetate	103-139	homeobox C11	Homo sapiens	27-33
11032759-5	2000	We report the isolation of HoxC11 in a yeast one-hybrid screen for factors binding to a phorbol-ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (VLTRE), which is also a target for TPA-induced binding of Rel factors in gel-shift experiments.	Tetradecanoylphorbol Acetate	141-144	homeobox C11	Homo sapiens	27-33
11032759-5	2000	We report the isolation of HoxC11 in a yeast one-hybrid screen for factors binding to a phorbol-ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (VLTRE), which is also a target for TPA-induced binding of Rel factors in gel-shift experiments.	Tetradecanoylphorbol Acetate	199-202	homeobox C11	Homo sapiens	27-33
11032759-6	2000	Although we detect no binding of in vitro translated HoxC11 to the TPA response element in EMSA, overexpression of HoxC11 in the HepG2 cell line leads to a complete block of TPA-induced transcription from a VLTRE-luciferase reporter.	Tetradecanoylphorbol Acetate	67-70	homeobox C11	Homo sapiens	115-121
11032759-6	2000	Although we detect no binding of in vitro translated HoxC11 to the TPA response element in EMSA, overexpression of HoxC11 in the HepG2 cell line leads to a complete block of TPA-induced transcription from a VLTRE-luciferase reporter.	Tetradecanoylphorbol Acetate	174-177	homeobox C11	Homo sapiens	115-121
10818238-3	2000	Differentiation of U937 and HPM cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced the H1 receptor expression and rather suppressed the H2 receptor, resulting in up-regulation of the histamine-induced expression and secretion of TNF-alpha, modulated via TACE.	Tetradecanoylphorbol Acetate	43-79	tumor necrosis factor	Homo sapiens	241-250
10818238-3	2000	Differentiation of U937 and HPM cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced the H1 receptor expression and rather suppressed the H2 receptor, resulting in up-regulation of the histamine-induced expression and secretion of TNF-alpha, modulated via TACE.	Tetradecanoylphorbol Acetate	81-84	tumor necrosis factor	Homo sapiens	241-250
10807873-8	2000	Phorbol 12-myristate 13-acetate (PMA) and insulin, 2 known activators of AP-1, increased the binding of AP-1 to the MMP-12 promoter, with higher affinity for the A allele.	Tetradecanoylphorbol Acetate	0-31	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-77
10807873-8	2000	Phorbol 12-myristate 13-acetate (PMA) and insulin, 2 known activators of AP-1, increased the binding of AP-1 to the MMP-12 promoter, with higher affinity for the A allele.	Tetradecanoylphorbol Acetate	0-31	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-108
10807873-8	2000	Phorbol 12-myristate 13-acetate (PMA) and insulin, 2 known activators of AP-1, increased the binding of AP-1 to the MMP-12 promoter, with higher affinity for the A allele.	Tetradecanoylphorbol Acetate	33-36	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-77
10807873-8	2000	Phorbol 12-myristate 13-acetate (PMA) and insulin, 2 known activators of AP-1, increased the binding of AP-1 to the MMP-12 promoter, with higher affinity for the A allele.	Tetradecanoylphorbol Acetate	33-36	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-108
10788447-5	2000	Interestingly, cotreatment with PMA (400 nm) attenuated IGF-1-induced activation of Akt.	Tetradecanoylphorbol Acetate	32-35	AKT serine/threonine kinase 1	Rattus norvegicus	84-87
10788429-6	2000	Acute phorbol 12-myristate 13-acetate pretreatment also inhibited TNFalpha-stimulated SAP kinase activity, while chronic pretreatment reversed the effects of UTP.	Tetradecanoylphorbol Acetate	6-37	tumor necrosis factor	Homo sapiens	66-74
10802049-5	2000	Moreover, bradykinin (BK), thrombin and phorbol 12-myristate 13-acetate induced rapid stimulation of PLD activity in CELMs.	Tetradecanoylphorbol Acetate	40-71	phospholipase D1	Homo sapiens	101-104
10788484-2	2000	Exposure of human pulmonary microvascular endothelial cells (HPMECs) to phorbol 12-myristate 13-acetate (PMA) leads to the increase of prostaglandin H synthase (PGHS)-2 protein levels.	Tetradecanoylphorbol Acetate	72-103	prostaglandin-endoperoxide synthase 2	Homo sapiens	135-168
10788484-2	2000	Exposure of human pulmonary microvascular endothelial cells (HPMECs) to phorbol 12-myristate 13-acetate (PMA) leads to the increase of prostaglandin H synthase (PGHS)-2 protein levels.	Tetradecanoylphorbol Acetate	105-108	prostaglandin-endoperoxide synthase 2	Homo sapiens	135-168
10788484-8	2000	Furthermore, in HPMEC medium, PMA-induced PGHS-2 expression was accompanied by the generation of a transferable activity (TA) able to abolish platelet aggregation.	Tetradecanoylphorbol Acetate	30-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	42-48
10788447-2	2000	In this study, we characterized the intracellular pathways involved in IGF-1-induced activation of Akt and evaluated the effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) on the Akt activation by IGF-1.	Tetradecanoylphorbol Acetate	150-181	AKT serine/threonine kinase 1	Rattus norvegicus	195-198
10788447-2	2000	In this study, we characterized the intracellular pathways involved in IGF-1-induced activation of Akt and evaluated the effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) on the Akt activation by IGF-1.	Tetradecanoylphorbol Acetate	183-186	AKT serine/threonine kinase 1	Rattus norvegicus	195-198
10779414-5	2000	Accordingly, the PKC activator phorbol myristate acetate up-regulated LAT expression.	Tetradecanoylphorbol Acetate	31-56	proline rich transmembrane protein 2	Homo sapiens	17-20
10783132-4	2000	Using a protein kinase (PK) C inhibitor, bisindolylmaleimide I, PMA-induced cell cornification and SPRR1 gene expression were abolished.	Tetradecanoylphorbol Acetate	64-67	proline rich transmembrane protein 2	Homo sapiens	8-29
10775457-2	2000	Now we report that addition of a PKC-alpha-enriched purified PKC preparation or recombinant PKC-alpha to a plasma membrane-enriched membrane fraction, isolated from leukemic HL60 cells, greatly ( approximately 6.5-fold stimulation) enhanced PtdEtn hydrolysis if the PKC activator phorbol 12-myristate 13-acetate (PMA) and ATP were both present; this was accompanied by PKC-mediated phosphorylation of several membrane proteins.	Tetradecanoylphorbol Acetate	280-311	protein kinase C alpha	Homo sapiens	33-42
10775457-2	2000	Now we report that addition of a PKC-alpha-enriched purified PKC preparation or recombinant PKC-alpha to a plasma membrane-enriched membrane fraction, isolated from leukemic HL60 cells, greatly ( approximately 6.5-fold stimulation) enhanced PtdEtn hydrolysis if the PKC activator phorbol 12-myristate 13-acetate (PMA) and ATP were both present; this was accompanied by PKC-mediated phosphorylation of several membrane proteins.	Tetradecanoylphorbol Acetate	280-311	protein kinase C alpha	Homo sapiens	33-36
10775457-2	2000	Now we report that addition of a PKC-alpha-enriched purified PKC preparation or recombinant PKC-alpha to a plasma membrane-enriched membrane fraction, isolated from leukemic HL60 cells, greatly ( approximately 6.5-fold stimulation) enhanced PtdEtn hydrolysis if the PKC activator phorbol 12-myristate 13-acetate (PMA) and ATP were both present; this was accompanied by PKC-mediated phosphorylation of several membrane proteins.	Tetradecanoylphorbol Acetate	280-311	protein kinase C alpha	Homo sapiens	92-101
10775457-2	2000	Now we report that addition of a PKC-alpha-enriched purified PKC preparation or recombinant PKC-alpha to a plasma membrane-enriched membrane fraction, isolated from leukemic HL60 cells, greatly ( approximately 6.5-fold stimulation) enhanced PtdEtn hydrolysis if the PKC activator phorbol 12-myristate 13-acetate (PMA) and ATP were both present; this was accompanied by PKC-mediated phosphorylation of several membrane proteins.	Tetradecanoylphorbol Acetate	280-311	protein kinase C alpha	Homo sapiens	61-64
10775457-2	2000	Now we report that addition of a PKC-alpha-enriched purified PKC preparation or recombinant PKC-alpha to a plasma membrane-enriched membrane fraction, isolated from leukemic HL60 cells, greatly ( approximately 6.5-fold stimulation) enhanced PtdEtn hydrolysis if the PKC activator phorbol 12-myristate 13-acetate (PMA) and ATP were both present; this was accompanied by PKC-mediated phosphorylation of several membrane proteins.	Tetradecanoylphorbol Acetate	313-316	protein kinase C alpha	Homo sapiens	33-42
10775457-2	2000	Now we report that addition of a PKC-alpha-enriched purified PKC preparation or recombinant PKC-alpha to a plasma membrane-enriched membrane fraction, isolated from leukemic HL60 cells, greatly ( approximately 6.5-fold stimulation) enhanced PtdEtn hydrolysis if the PKC activator phorbol 12-myristate 13-acetate (PMA) and ATP were both present; this was accompanied by PKC-mediated phosphorylation of several membrane proteins.	Tetradecanoylphorbol Acetate	313-316	protein kinase C alpha	Homo sapiens	33-36
10775457-2	2000	Now we report that addition of a PKC-alpha-enriched purified PKC preparation or recombinant PKC-alpha to a plasma membrane-enriched membrane fraction, isolated from leukemic HL60 cells, greatly ( approximately 6.5-fold stimulation) enhanced PtdEtn hydrolysis if the PKC activator phorbol 12-myristate 13-acetate (PMA) and ATP were both present; this was accompanied by PKC-mediated phosphorylation of several membrane proteins.	Tetradecanoylphorbol Acetate	313-316	protein kinase C alpha	Homo sapiens	92-101
10775457-2	2000	Now we report that addition of a PKC-alpha-enriched purified PKC preparation or recombinant PKC-alpha to a plasma membrane-enriched membrane fraction, isolated from leukemic HL60 cells, greatly ( approximately 6.5-fold stimulation) enhanced PtdEtn hydrolysis if the PKC activator phorbol 12-myristate 13-acetate (PMA) and ATP were both present; this was accompanied by PKC-mediated phosphorylation of several membrane proteins.	Tetradecanoylphorbol Acetate	313-316	protein kinase C alpha	Homo sapiens	61-64
10837911-10	2000	AATYK-induced differentiation was in the same range as the differentiation induced by agents like all-trans retinoic acid (RA), 12-O-Tetradecanoyl phorbol 13-acetate (TPA) and IGF-I.	Tetradecanoylphorbol Acetate	128-165	apoptosis associated tyrosine kinase	Homo sapiens	0-5
10837911-10	2000	AATYK-induced differentiation was in the same range as the differentiation induced by agents like all-trans retinoic acid (RA), 12-O-Tetradecanoyl phorbol 13-acetate (TPA) and IGF-I.	Tetradecanoylphorbol Acetate	167-170	apoptosis associated tyrosine kinase	Homo sapiens	0-5
10793091-3	2000	When monocytes/macrophages were subjected to 4% strain at 1 Hz for 24 hours, neither matrix metalloproteinase (MMP)-1 nor MMP-3 was induced; however, in the presence of phorbol myristate acetate, strain augmented MMP-1 expression by 5.1 +/- 0.7-fold (P &lt; 0.05) and MMP-3 expression by 1.	Tetradecanoylphorbol Acetate	169-194	matrix metallopeptidase 3	Homo sapiens	268-273
11368885-7	2000	In addition, the modulatory effects of Samultang on LPS/PMA-induced cytotoxicity and NO production could be mimicked by exogenous treatments of N(G)MMA, a nitric oxide synthase (NOS) inhibitor, and pyrrolidine dithiocarbamate (PDTC), a strong NF-kappaB inhibitor.	Tetradecanoylphorbol Acetate	56-59	nitric oxide synthase 2	Homo sapiens	155-176
10811116-1	2000	We investigated the effects of ursolic acid, a chemopreventive agent, on the expression of cyclooxygenase-2 (COX-2) in phorbol 12-myristate 13-acetate (PMA)-treated human mammary and oral epithelial cells.	Tetradecanoylphorbol Acetate	119-150	prostaglandin-endoperoxide synthase 2	Homo sapiens	91-107
10811116-1	2000	We investigated the effects of ursolic acid, a chemopreventive agent, on the expression of cyclooxygenase-2 (COX-2) in phorbol 12-myristate 13-acetate (PMA)-treated human mammary and oral epithelial cells.	Tetradecanoylphorbol Acetate	119-150	prostaglandin-endoperoxide synthase 2	Homo sapiens	109-114
10811116-1	2000	We investigated the effects of ursolic acid, a chemopreventive agent, on the expression of cyclooxygenase-2 (COX-2) in phorbol 12-myristate 13-acetate (PMA)-treated human mammary and oral epithelial cells.	Tetradecanoylphorbol Acetate	152-155	prostaglandin-endoperoxide synthase 2	Homo sapiens	91-107
10811116-1	2000	We investigated the effects of ursolic acid, a chemopreventive agent, on the expression of cyclooxygenase-2 (COX-2) in phorbol 12-myristate 13-acetate (PMA)-treated human mammary and oral epithelial cells.	Tetradecanoylphorbol Acetate	152-155	prostaglandin-endoperoxide synthase 2	Homo sapiens	109-114
10811116-2	2000	Treatment with ursolic acid suppressed PMA-mediated induction of COX-2 protein and synthesis of prostaglandin E2.	Tetradecanoylphorbol Acetate	39-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	65-70
10811116-6	2000	Ursolic acid inhibited PMA-mediated activation of protein kinase C, extracellular signal-regulated kinase 1/2, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinases.	Tetradecanoylphorbol Acetate	23-26	mitogen-activated protein kinase 3	Homo sapiens	68-134
10811116-6	2000	Ursolic acid inhibited PMA-mediated activation of protein kinase C, extracellular signal-regulated kinase 1/2, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinases.	Tetradecanoylphorbol Acetate	23-26	mitogen-activated protein kinase 14	Homo sapiens	140-143
10792375-3	2000	Upon cell activation by phorbol myristate acetate and ionomycin, the proportion of CD4+ T cells containing interferon-gamma (IFN-gamma) was found to be greater in the old subjects.	Tetradecanoylphorbol Acetate	24-49	CD4 molecule	Homo sapiens	83-86
10792375-3	2000	Upon cell activation by phorbol myristate acetate and ionomycin, the proportion of CD4+ T cells containing interferon-gamma (IFN-gamma) was found to be greater in the old subjects.	Tetradecanoylphorbol Acetate	24-49	interferon gamma	Homo sapiens	107-123
10792375-3	2000	Upon cell activation by phorbol myristate acetate and ionomycin, the proportion of CD4+ T cells containing interferon-gamma (IFN-gamma) was found to be greater in the old subjects.	Tetradecanoylphorbol Acetate	24-49	interferon gamma	Homo sapiens	125-134
10772818-5	2000	Both TPA and NGF induced a sustained activation and nuclear accumulation of ERK that was accompanied by transactivation of a serum response element (SRE)-driven reporter and of the c-fos gene.	Tetradecanoylphorbol Acetate	5-8	mitogen-activated protein kinase 1	Homo sapiens	76-79
10773108-10	2000	Therefore, HL-60 cells exhibit an increase in CaR protein expression, occurring at a translational level during their differentiation into cells with a monocyte/macrophage phenotype in response to treatment with PMA or 1, 25(OH)(2)D(3), which is functionally linked to activation of a nonselective cation channel.	Tetradecanoylphorbol Acetate	212-215	calcium sensing receptor	Homo sapiens	46-49
10785383-4	2000	In experiments with TACE deficient (TACE-/-) fibroblasts we found that 4beta-phorbol 12-myristate 13-acetate (PMA)-induced shedding of the interleukin-6 receptor (IL-6R) is strongly reduced.	Tetradecanoylphorbol Acetate	71-108	a disintegrin and metallopeptidase domain 17	Mus musculus	20-24
10785383-4	2000	In experiments with TACE deficient (TACE-/-) fibroblasts we found that 4beta-phorbol 12-myristate 13-acetate (PMA)-induced shedding of the interleukin-6 receptor (IL-6R) is strongly reduced.	Tetradecanoylphorbol Acetate	71-108	a disintegrin and metallopeptidase domain 17	Mus musculus	36-40
10785383-4	2000	In experiments with TACE deficient (TACE-/-) fibroblasts we found that 4beta-phorbol 12-myristate 13-acetate (PMA)-induced shedding of the interleukin-6 receptor (IL-6R) is strongly reduced.	Tetradecanoylphorbol Acetate	71-108	interleukin 6 receptor, alpha	Mus musculus	139-161
10785383-4	2000	In experiments with TACE deficient (TACE-/-) fibroblasts we found that 4beta-phorbol 12-myristate 13-acetate (PMA)-induced shedding of the interleukin-6 receptor (IL-6R) is strongly reduced.	Tetradecanoylphorbol Acetate	71-108	interleukin 6 receptor, alpha	Mus musculus	163-168
10785383-4	2000	In experiments with TACE deficient (TACE-/-) fibroblasts we found that 4beta-phorbol 12-myristate 13-acetate (PMA)-induced shedding of the interleukin-6 receptor (IL-6R) is strongly reduced.	Tetradecanoylphorbol Acetate	110-113	a disintegrin and metallopeptidase domain 17	Mus musculus	20-24
10785383-4	2000	In experiments with TACE deficient (TACE-/-) fibroblasts we found that 4beta-phorbol 12-myristate 13-acetate (PMA)-induced shedding of the interleukin-6 receptor (IL-6R) is strongly reduced.	Tetradecanoylphorbol Acetate	110-113	a disintegrin and metallopeptidase domain 17	Mus musculus	36-40
10785383-4	2000	In experiments with TACE deficient (TACE-/-) fibroblasts we found that 4beta-phorbol 12-myristate 13-acetate (PMA)-induced shedding of the interleukin-6 receptor (IL-6R) is strongly reduced.	Tetradecanoylphorbol Acetate	110-113	interleukin 6 receptor, alpha	Mus musculus	139-161
10785383-4	2000	In experiments with TACE deficient (TACE-/-) fibroblasts we found that 4beta-phorbol 12-myristate 13-acetate (PMA)-induced shedding of the interleukin-6 receptor (IL-6R) is strongly reduced.	Tetradecanoylphorbol Acetate	110-113	interleukin 6 receptor, alpha	Mus musculus	163-168
10785383-7	2000	PMA-induced shedding of IL-6R in TACE deficient mouse fibroblasts could be restored by stable transfection of a TACE cDNA.	Tetradecanoylphorbol Acetate	0-3	interleukin 6 receptor, alpha	Mus musculus	24-29
10785383-7	2000	PMA-induced shedding of IL-6R in TACE deficient mouse fibroblasts could be restored by stable transfection of a TACE cDNA.	Tetradecanoylphorbol Acetate	0-3	a disintegrin and metallopeptidase domain 17	Mus musculus	33-37
10785383-7	2000	PMA-induced shedding of IL-6R in TACE deficient mouse fibroblasts could be restored by stable transfection of a TACE cDNA.	Tetradecanoylphorbol Acetate	0-3	a disintegrin and metallopeptidase domain 17	Mus musculus	112-116
10768988-4	2000	HBD-2 mRNA was also induced by the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), an epithelial cell activator.	Tetradecanoylphorbol Acetate	104-129	defensin beta 4A	Homo sapiens	0-5
10768988-4	2000	HBD-2 mRNA was also induced by the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), an epithelial cell activator.	Tetradecanoylphorbol Acetate	131-134	defensin beta 4A	Homo sapiens	0-5
10808178-6	2000	Although the majority of lymphocytes remained in the peritoneum, significant numbers of T lymphocytes were located in the spleen, where human IL-4, IL-5, and IFN-gamma messenger RNA expression was detected after stimulation with PHA and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	237-262	interleukin 4	Homo sapiens	142-146
10808178-6	2000	Although the majority of lymphocytes remained in the peritoneum, significant numbers of T lymphocytes were located in the spleen, where human IL-4, IL-5, and IFN-gamma messenger RNA expression was detected after stimulation with PHA and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	237-262	interferon gamma	Homo sapiens	158-167
10833370-5	2000	IL-6 transcription and secretion were dose-dependently enhanced by stimulation with IL-1beta, tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1 and 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	173-210	interleukin 6	Homo sapiens	0-4
10804017-4	2000	Phorbol myristate acetate (PMA), a PKC agonist, increased TGF-beta1 but not TGF-beta2 concentrations.	Tetradecanoylphorbol Acetate	0-25	transforming growth factor beta 1	Homo sapiens	58-67
10804017-4	2000	Phorbol myristate acetate (PMA), a PKC agonist, increased TGF-beta1 but not TGF-beta2 concentrations.	Tetradecanoylphorbol Acetate	27-30	transforming growth factor beta 1	Homo sapiens	58-67
10811002-7	2000	Moreover, pretreatment of the cells with the protein kinase C (PKC) inhibitors GF-109203X and RO-31-8220 and down-regulation of PKCalpha by prolonged treatment with 4beta-phorbol 12-myristate 13-acetate inhibited the H2O2-stimulated PLD2 activity, which points to the involvement of PKCalpha.	Tetradecanoylphorbol Acetate	165-202	protein kinase C, alpha	Mus musculus	63-66
10811002-7	2000	Moreover, pretreatment of the cells with the protein kinase C (PKC) inhibitors GF-109203X and RO-31-8220 and down-regulation of PKCalpha by prolonged treatment with 4beta-phorbol 12-myristate 13-acetate inhibited the H2O2-stimulated PLD2 activity, which points to the involvement of PKCalpha.	Tetradecanoylphorbol Acetate	165-202	protein kinase C, alpha	Mus musculus	128-136
10811002-7	2000	Moreover, pretreatment of the cells with the protein kinase C (PKC) inhibitors GF-109203X and RO-31-8220 and down-regulation of PKCalpha by prolonged treatment with 4beta-phorbol 12-myristate 13-acetate inhibited the H2O2-stimulated PLD2 activity, which points to the involvement of PKCalpha.	Tetradecanoylphorbol Acetate	165-202	protein kinase C, alpha	Mus musculus	283-291
10833370-5	2000	IL-6 transcription and secretion were dose-dependently enhanced by stimulation with IL-1beta, tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1 and 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	212-215	interleukin 6	Homo sapiens	0-4
10833370-8	2000	The TPA-induced production of IL-6 was inhibited by 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine and sphyngosine, suggesting the involvement of a protein kinase C-dependent pathway.	Tetradecanoylphorbol Acetate	4-7	interleukin 6	Homo sapiens	30-34
10833370-9	2000	Levels of IL-8 mRNA and protein were also dose-dependently increased by stimulation with IL-1beta, TNF-alpha and TPA.	Tetradecanoylphorbol Acetate	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
10781803-0	2000	MAPK-dependent expression of p21(WAF) and p27(kip1) in PMA-induced differentiation of HL60 cells.	Tetradecanoylphorbol Acetate	55-58	cyclin dependent kinase inhibitor 1A	Homo sapiens	29-32
10754211-2	2000	12-O-tetradecanoylphorbol-13-acetate (TPA) and hydrogen peroxide, known as cancer promoters, inhibited GJIC in the epithelial cells as determined by the scrape loading/dye transfer assay, fluorescence redistribution assay after photobleaching, and immunofluorescent staining of connexin 43 using a laser confocal microscope.	Tetradecanoylphorbol Acetate	0-36	gap junction protein, alpha 1	Rattus norvegicus	278-289
10754211-2	2000	12-O-tetradecanoylphorbol-13-acetate (TPA) and hydrogen peroxide, known as cancer promoters, inhibited GJIC in the epithelial cells as determined by the scrape loading/dye transfer assay, fluorescence redistribution assay after photobleaching, and immunofluorescent staining of connexin 43 using a laser confocal microscope.	Tetradecanoylphorbol Acetate	38-41	gap junction protein, alpha 1	Rattus norvegicus	278-289
10766857-3	2000	We report that IL-8 mRNA accumulation and protein secretion were down-regulated in IL-1beta- and lipopolysaccharide-stimulated differentiated HT-29 cells (HT-29/MTX, where MTX is methotrexate) compared with undifferentiated cells (HT-29/p), whereas no differential effects were found following tumor necrosis factor (TNF)-alpha or phorbol myristate acetate stimulation.	Tetradecanoylphorbol Acetate	331-356	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
10766857-3	2000	We report that IL-8 mRNA accumulation and protein secretion were down-regulated in IL-1beta- and lipopolysaccharide-stimulated differentiated HT-29 cells (HT-29/MTX, where MTX is methotrexate) compared with undifferentiated cells (HT-29/p), whereas no differential effects were found following tumor necrosis factor (TNF)-alpha or phorbol myristate acetate stimulation.	Tetradecanoylphorbol Acetate	331-356	interleukin 1 beta	Homo sapiens	83-91
10777594-6	2000	Moreover, phorbol myristate acetate, a potent anti-apoptotic effector, was found to protect SRF completely from cleavage by caspase 3 and also to prevent the inhibition of the c-FOS promoter activity by death effectors.	Tetradecanoylphorbol Acetate	10-35	caspase 3	Homo sapiens	124-133
10781803-0	2000	MAPK-dependent expression of p21(WAF) and p27(kip1) in PMA-induced differentiation of HL60 cells.	Tetradecanoylphorbol Acetate	55-58	zinc ribbon domain containing 2	Homo sapiens	42-45
10781803-3	2000	PMA induces rapid activation of the extracellular signal-regulated kinases (ERKs).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	76-80
10781803-4	2000	Activation of the ERK pathway is essential to PMA-induced differentiation of HL60 cells.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 1	Homo sapiens	18-21
10781803-5	2000	PMA also induces the expression of the cyclin-dependent kinase inhibitors p21(WAF) and p27(kip1), which is modulated by the use of an inhibitor of the ERK cascade.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	74-77
10781803-5	2000	PMA also induces the expression of the cyclin-dependent kinase inhibitors p21(WAF) and p27(kip1), which is modulated by the use of an inhibitor of the ERK cascade.	Tetradecanoylphorbol Acetate	0-3	zinc ribbon domain containing 2	Homo sapiens	87-90
10781803-5	2000	PMA also induces the expression of the cyclin-dependent kinase inhibitors p21(WAF) and p27(kip1), which is modulated by the use of an inhibitor of the ERK cascade.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	151-154
10753946-2	2000	In phorbol ester-sensitive EL4 thymoma cells, phorbol-12-myristate 13-acetate (PMA) induces activation of extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases and promotes cell adhesion.	Tetradecanoylphorbol Acetate	46-77	mitogen-activated protein kinase 1	Mus musculus	106-143
10749687-7	2000	Furthermore, PMA-induced Pyk2 (and FAK) tyrosine phosphorylation was also observed when platelets adhered to immobilized fibrinogen.	Tetradecanoylphorbol Acetate	13-16	fibrinogen beta chain	Homo sapiens	121-131
10753939-6	2000	p38 activity was specifically associated with arachidonic acid-stimulated adhesion; this was demonstrated by the observation that 12-O-tetradecanoylphorbol 13-acetate-activated cell adhesion was not blocked by inhibiting p38 activity.	Tetradecanoylphorbol Acetate	130-166	mitogen-activated protein kinase 1	Homo sapiens	0-3
10753946-2	2000	In phorbol ester-sensitive EL4 thymoma cells, phorbol-12-myristate 13-acetate (PMA) induces activation of extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases and promotes cell adhesion.	Tetradecanoylphorbol Acetate	46-77	mitogen-activated protein kinase 1	Mus musculus	145-148
10753946-2	2000	In phorbol ester-sensitive EL4 thymoma cells, phorbol-12-myristate 13-acetate (PMA) induces activation of extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases and promotes cell adhesion.	Tetradecanoylphorbol Acetate	79-82	mitogen-activated protein kinase 1	Mus musculus	106-143
10753946-2	2000	In phorbol ester-sensitive EL4 thymoma cells, phorbol-12-myristate 13-acetate (PMA) induces activation of extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases and promotes cell adhesion.	Tetradecanoylphorbol Acetate	79-82	mitogen-activated protein kinase 1	Mus musculus	145-148
10753946-4	2000	Paxillin, a multifunctional docking protein involved in cell adhesion, was phosphorylated on serine/threonine residues in response to PMA treatment.	Tetradecanoylphorbol Acetate	134-137	paxillin	Mus musculus	0-8
10753946-6	2000	PMA-induced phosphorylation of paxillin was inhibited by compounds that block the ERK activation pathway in EL4 cells, primary murine thymocytes, and primary murine splenocytes.	Tetradecanoylphorbol Acetate	0-3	paxillin	Mus musculus	31-39
10753946-6	2000	PMA-induced phosphorylation of paxillin was inhibited by compounds that block the ERK activation pathway in EL4 cells, primary murine thymocytes, and primary murine splenocytes.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Mus musculus	82-85
10753946-8	2000	Two-dimensional electrophoresis revealed that PMA treatment generated a complex pattern of phosphorylated paxillin species in intact cells, some of which were generated by ERK-mediated phosphorylation in vitro.	Tetradecanoylphorbol Acetate	46-49	paxillin	Mus musculus	106-114
10753946-8	2000	Two-dimensional electrophoresis revealed that PMA treatment generated a complex pattern of phosphorylated paxillin species in intact cells, some of which were generated by ERK-mediated phosphorylation in vitro.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 1	Mus musculus	172-175
10753946-9	2000	An ERK pathway inhibitor interfered with PMA-induced adhesion of sensitive EL4 cells to substrate.	Tetradecanoylphorbol Acetate	41-44	mitogen-activated protein kinase 1	Mus musculus	3-6
10805218-7	2000	Treatment of the cells with 1 microM phorbol 12-myristate-13-acetate (PMA) stimulated IFN-gamma mRNA expression but had no effect on IFN-gamma protein production.	Tetradecanoylphorbol Acetate	37-68	interferon gamma	Homo sapiens	86-95
10739673-6	2000	These data indicate that serine proteases specifically mediate many of the phenotypic aspects of TPA-induced monocytic differentiation but are not involved with the induction or repression of differentiation-sensitive transcription factors and suggest that serine protease activity is required for intracellular processing of CD11b.	Tetradecanoylphorbol Acetate	97-100	coagulation factor II, thrombin	Homo sapiens	25-40
10745027-5	2000	On the other hand, activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate inhibits both H(2)O(2)-induced ceramide production and apoptosis.	Tetradecanoylphorbol Acetate	59-95	proline rich transmembrane protein 2	Homo sapiens	33-49
10745027-5	2000	On the other hand, activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate inhibits both H(2)O(2)-induced ceramide production and apoptosis.	Tetradecanoylphorbol Acetate	59-95	proline rich transmembrane protein 2	Homo sapiens	51-54
10727412-7	2000	In addition, treatment of the cells with PMA, which activates PKC-theta and hence increases the phosphorylation state of MARCKS, reversibly inhibited both MARCKS translocation and myoblast fusion.	Tetradecanoylphorbol Acetate	41-44	myristoylated alanine rich protein kinase C substrate	Gallus gallus	121-127
10727412-7	2000	In addition, treatment of the cells with PMA, which activates PKC-theta and hence increases the phosphorylation state of MARCKS, reversibly inhibited both MARCKS translocation and myoblast fusion.	Tetradecanoylphorbol Acetate	41-44	myristoylated alanine rich protein kinase C substrate	Gallus gallus	155-161
10775036-5	2000	PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	58-62
10775036-5	2000	PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 7	Homo sapiens	71-74
10775036-5	2000	PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	79-90
10775036-5	2000	PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Homo sapiens	86-90
10775036-5	2000	PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1.	Tetradecanoylphorbol Acetate	175-178	mitogen-activated protein kinase 3	Homo sapiens	58-62
10775036-5	2000	PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1.	Tetradecanoylphorbol Acetate	175-178	mitogen-activated protein kinase kinase 7	Homo sapiens	71-74
10775036-5	2000	PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1.	Tetradecanoylphorbol Acetate	175-178	mitogen-activated protein kinase 3	Homo sapiens	79-90
10775036-5	2000	PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1.	Tetradecanoylphorbol Acetate	175-178	mitogen-activated protein kinase 3	Homo sapiens	86-90
10775036-10	2000	Furthermore, transient transfection with an inactive, dominant-negative MEK mutant also inhibited PMA-induced differentiation, whereas transient transfection with a plasmid coding for constitutively activated MEK led to macrophage-like differentiation in the absence of PMA.	Tetradecanoylphorbol Acetate	98-101	mitogen-activated protein kinase kinase 7	Homo sapiens	72-75
10805218-7	2000	Treatment of the cells with 1 microM phorbol 12-myristate-13-acetate (PMA) stimulated IFN-gamma mRNA expression but had no effect on IFN-gamma protein production.	Tetradecanoylphorbol Acetate	70-73	interferon gamma	Homo sapiens	86-95
10792503-4	2000	PMA stimulation also increased the expression of both pro-caspase-8 and pro-caspase-3 in U937, but not apoptosis or intracellular caspase-3 activity.	Tetradecanoylphorbol Acetate	0-3	caspase 3	Homo sapiens	72-85
10813091-6	2000	However, the hemoglobin-induced enhancement of PMA-stimulated CL is inhibited by superoxide dismutase, catalase, dimethylthiourea, or deferoxamine.	Tetradecanoylphorbol Acetate	47-50	catalase	Rattus norvegicus	103-111
10781899-4	2000	We used the immortalized human megakaryoblastic cell line MEG-01 as a model to study the expression of PGHS-1, because MEG-01 cells can be induced to differentiate into platelet-like structures by adding nanomolar concentrations of 12-0-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	270-273	prostaglandin-endoperoxide synthase 1	Homo sapiens	103-109
10781899-9	2000	Addition of TPA induced the expression of PGHS-1 protein and mRNA in all three populations but did not change the relationship of the amount of PGHS-1 protein or mRNA expressed in a given population relative to the other two fractions.	Tetradecanoylphorbol Acetate	12-15	prostaglandin-endoperoxide synthase 1	Homo sapiens	42-48
10781899-12	2000	We measured a time-dependent increase in the percentage of cells that expressed PGHS-1 over a period of 8 days after singular addition of TPA (1.6x10(-8)M).	Tetradecanoylphorbol Acetate	138-141	prostaglandin-endoperoxide synthase 1	Homo sapiens	80-86
10792503-4	2000	PMA stimulation also increased the expression of both pro-caspase-8 and pro-caspase-3 in U937, but not apoptosis or intracellular caspase-3 activity.	Tetradecanoylphorbol Acetate	0-3	caspase 3	Homo sapiens	76-85
10792503-7	2000	When a potent NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), was added to U937 cell culture in the presence of PMA, apoptosis was triggered by activation of caspase-3, which was induced by caspase-8 activation.	Tetradecanoylphorbol Acetate	121-124	caspase 3	Homo sapiens	167-176
10792503-9	2000	The inhibitors of caspase-8 and caspase-3 mostly inhibited apoptosis of U937 treated with PMA in the presence of PDTC.	Tetradecanoylphorbol Acetate	90-93	caspase 3	Homo sapiens	32-41
10770281-4	2000	CRP inhibited phorbol myristate acetate-induced superoxide (O2-) production more efficiently than the fMLP-triggered response.	Tetradecanoylphorbol Acetate	14-39	C-reactive protein	Homo sapiens	0-3
10756114-6	2000	Downregulation of PKC by chronic pretreatment with 10 n m phorbol 12-myristate 13-acetate (PMA) also prevented ET-1-induced mitogenesis.	Tetradecanoylphorbol Acetate	58-89	endothelin 1	Rattus norvegicus	111-115
10756114-6	2000	Downregulation of PKC by chronic pretreatment with 10 n m phorbol 12-myristate 13-acetate (PMA) also prevented ET-1-induced mitogenesis.	Tetradecanoylphorbol Acetate	91-94	endothelin 1	Rattus norvegicus	111-115
10694746-6	2000	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC) activator, increased the phosphorylation of Cx43, but decreased Cx43 positive spots.	Tetradecanoylphorbol Acetate	19-55	gap junction protein, alpha 1	Mus musculus	132-136
10694746-6	2000	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC) activator, increased the phosphorylation of Cx43, but decreased Cx43 positive spots.	Tetradecanoylphorbol Acetate	19-55	gap junction protein, alpha 1	Mus musculus	152-156
10694746-6	2000	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC) activator, increased the phosphorylation of Cx43, but decreased Cx43 positive spots.	Tetradecanoylphorbol Acetate	57-60	gap junction protein, alpha 1	Mus musculus	132-136
10694746-6	2000	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC) activator, increased the phosphorylation of Cx43, but decreased Cx43 positive spots.	Tetradecanoylphorbol Acetate	57-60	gap junction protein, alpha 1	Mus musculus	152-156
10694448-8	2000	However, PMA, a phorbol ester that inhibits Col2a1 expression and chondrocyte differentiation, had an unexpectedly modest effect on Sox9 RNA accumulation.	Tetradecanoylphorbol Acetate	9-12	collagen type II alpha 1 chain	Gallus gallus	44-50
10747291-2	2000	Since the nuclear factor kappaB (NF-kappaB) family of transcription factors plays a major role in these biological processes, we sought to elucidate its expression in newborn mouse skin upon UV and 12-O-tetradecanoylphorbol-13-acetate (TPA) exposures.	Tetradecanoylphorbol Acetate	198-234	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	25-31
10747291-2	2000	Since the nuclear factor kappaB (NF-kappaB) family of transcription factors plays a major role in these biological processes, we sought to elucidate its expression in newborn mouse skin upon UV and 12-O-tetradecanoylphorbol-13-acetate (TPA) exposures.	Tetradecanoylphorbol Acetate	198-234	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	33-42
10747291-2	2000	Since the nuclear factor kappaB (NF-kappaB) family of transcription factors plays a major role in these biological processes, we sought to elucidate its expression in newborn mouse skin upon UV and 12-O-tetradecanoylphorbol-13-acetate (TPA) exposures.	Tetradecanoylphorbol Acetate	236-239	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	25-31
10747291-2	2000	Since the nuclear factor kappaB (NF-kappaB) family of transcription factors plays a major role in these biological processes, we sought to elucidate its expression in newborn mouse skin upon UV and 12-O-tetradecanoylphorbol-13-acetate (TPA) exposures.	Tetradecanoylphorbol Acetate	236-239	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	33-42
10777216-3	2000	A pronounced downregulation of cyclin A, and to a lesser extent of cyclin E, occurred in K562 cells during the first 24 h after TPA treatment, in contrast with re-replicating HEL cells, in which both cyclins were present in individual G2/M cells.	Tetradecanoylphorbol Acetate	128-131	cyclin A2	Homo sapiens	31-39
10777216-4	2000	Transactivation experiments suggested that the absence of cyclin A in differentiated K562 cells could be due to a TPA-mediated inhibition of its transcription.	Tetradecanoylphorbol Acetate	114-117	cyclin A2	Homo sapiens	58-66
10702314-5	2000	Granulocyte/macrophage colony-stimulating factor, interleukin 3, and TPA, all of which induced macrophage proliferation, also induced ERK activity, which was maximal at 5 min poststimulation.	Tetradecanoylphorbol Acetate	69-72	mitogen-activated protein kinase 1	Homo sapiens	134-137
10733524-3	2000	We show that induction of the circadian oscillation of gene expression is triggered by TPA treatment of NIH-3T3 fibroblasts, which is inhibited by a MEK inhibitor, and that prolonged activation of the MAPK cascade is sufficient to trigger circadian gene expression.	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase kinase 7	Homo sapiens	149-152
10699487-6	2000	Our data show that the syndecan-1 and glypican-1 mRNA expression is increased by the phorbol myristate acetate (PMA) suggesting a regulation of their expression by the phosphatidyl inositol pathway, as previously hypothesized (Fagen et al., Biochim.	Tetradecanoylphorbol Acetate	85-110	glypican 1	Rattus norvegicus	38-48
10699487-6	2000	Our data show that the syndecan-1 and glypican-1 mRNA expression is increased by the phorbol myristate acetate (PMA) suggesting a regulation of their expression by the phosphatidyl inositol pathway, as previously hypothesized (Fagen et al., Biochim.	Tetradecanoylphorbol Acetate	112-115	glypican 1	Rattus norvegicus	38-48
10711703-15	2000	We have previously demonstrated TPA-induced phosphorylation of the gap junction protein connexin56 (Cx56).	Tetradecanoylphorbol Acetate	32-35	gap junction protein alpha 3	Gallus gallus	88-98
10688817-5	2000	The target for this inhibition was Jak2, and the activation of PKC by 12-O-tetradecanoyl-phorbol-13-acetate treatment also abrogated IL-3-induced tyrosine phosphorylation of Jak2 in Ba/F3 cells.	Tetradecanoylphorbol Acetate	70-107	interleukin 3	Mus musculus	133-137
10702485-2	2000	We have used a modified version of the ELISPOT assay to monitor changes in the frequency of gamma interferon (IFN-gamma)-producing T cells in a population of lymphocytes responding to a relevant peptide or a nonspecific stimulator, such as phorbol myristate acetate-ionomycin.	Tetradecanoylphorbol Acetate	240-265	interferon gamma	Homo sapiens	92-119
10711703-15	2000	We have previously demonstrated TPA-induced phosphorylation of the gap junction protein connexin56 (Cx56).	Tetradecanoylphorbol Acetate	32-35	gap junction protein alpha 3	Gallus gallus	100-104
10692108-6	2000	Interferon-gamma and the phorbolester 12-O-tetradecanoyl phorbol 13-acetate, two well-known inducers of keratinocyte differentiation, both inhibited vitamin D receptor expression but only interferon-gamma induced retinoid X receptor alpha.	Tetradecanoylphorbol Acetate	38-75	interferon gamma	Homo sapiens	188-204
10692485-7	2000	In contrast, RGS2 mRNA was rapidly and dose dependently increased (395 +/- 24% peak, 45 min) by Ang II but returned to baseline level by 6 to 8 h. Phorbol-12-myristate-13-acetate, a PKC activator, robustly increased RGS2.	Tetradecanoylphorbol Acetate	147-178	angiotensinogen	Homo sapiens	96-102
10693946-3	2000	Significant increases in the levels of c-fos, c-jun, and egr-1 but not NGFIB mRNA were observed in PC12 cells exposed to lead or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	129-160	early growth response 1	Rattus norvegicus	57-62
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Tetradecanoylphorbol Acetate	152-155	formyl peptide receptor 1	Homo sapiens	227-231
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Tetradecanoylphorbol Acetate	152-155	integrin subunit beta 2	Homo sapiens	270-274
10693967-4	2000	Stimulation of Na+,K(+)-ATPase activity by Ang II was dependent on protein kinase C (PKC) activation because PKC antagonists abolished the inducing effect of Ang II and the PKC activator phorbol 12-myristate 13-acetate enhanced transporter activity.	Tetradecanoylphorbol Acetate	187-218	angiotensinogen	Rattus norvegicus	43-49
10703777-1	2000	CONTEXT: Little is known regarding outcomes after intravenous tissue-type plasminogen activator (IV tPA) therapy for acute ischemic stroke outside a trial setting.	Tetradecanoylphorbol Acetate	100-103	plasminogen activator, tissue type	Homo sapiens	62-95
10669554-11	2000	Furthermore, radioresistance by transfection with inducible Hsp70, as tested by clonogenic survival, disappeared after pretreatment with Pkc inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7), prolonged treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), and GF109203X.	Tetradecanoylphorbol Acetate	230-266	heat shock protein 1B	Mus musculus	60-65
10669554-11	2000	Furthermore, radioresistance by transfection with inducible Hsp70, as tested by clonogenic survival, disappeared after pretreatment with Pkc inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7), prolonged treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), and GF109203X.	Tetradecanoylphorbol Acetate	268-271	heat shock protein 1B	Mus musculus	60-65
10718373-6	2000	Treatment of PMNs with phorbol myristate acetate (PMA), a protein kinase C activator, completely abolished the intracellular Ca2+ level stimulated by PAF, but not the intracellular Ca2+ level stimulated by fMLP.	Tetradecanoylphorbol Acetate	50-53	formyl peptide receptor 1	Homo sapiens	206-210
10662792-6	2000	This inhibitory activity can be bypassed by the combination of phorbol myristate acetate (PMA) and ionomycin, suggesting that SLAP acts proximally in the TCR signaling pathway.	Tetradecanoylphorbol Acetate	63-88	Src like adaptor	Homo sapiens	126-130
10681596-2	2000	We found that upon thyrotropin-releasing hormone (TRH) or phorbol 12-myristate 13-acetate stimulation, hPKCalpha-GFP was localized exclusively in regions of cell-cell contacts.	Tetradecanoylphorbol Acetate	58-89	protein kinase C alpha	Homo sapiens	103-112
10679258-3	2000	We show that the activities of both ERK-1 and ERK-2 are upregulated in this model in response to TPA.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 1	Mus musculus	46-51
10675677-6	2000	TNFalpha production increased on exposure to zymosan, LPS and LPS-phorbol myristate acetate, though not on exposure to LB.	Tetradecanoylphorbol Acetate	66-91	tumor necrosis factor	Homo sapiens	0-8
10841038-4	2000	When these cells were pretreated with aspirin to inactivate their PGHS-1 and then activated by serum and phorbol ester (TPA) for 6 h, the cells expressed PGHS-2 activity alone.	Tetradecanoylphorbol Acetate	120-123	prostaglandin-endoperoxide synthase 2	Homo sapiens	154-160
10662792-6	2000	This inhibitory activity can be bypassed by the combination of phorbol myristate acetate (PMA) and ionomycin, suggesting that SLAP acts proximally in the TCR signaling pathway.	Tetradecanoylphorbol Acetate	90-93	Src like adaptor	Homo sapiens	126-130
10651808-9	2000	Measurement of PKC activity in the cytosolic and membrane fractions showed that pretreatment of PMNs with ethanol increased twofold the PMA-stimulated PKC activity in the membrane fraction.	Tetradecanoylphorbol Acetate	136-139	protein kinase C alpha	Homo sapiens	15-18
10735602-7	2000	However, by in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, peripheral CD4 cells demonstrated a significant decrease of IFN-gamma-producing T helper 1 (Th1) cells and an increase of IL-4-producing T helper 2 (Th2) cells after immunotherapy.	Tetradecanoylphorbol Acetate	37-68	CD4 molecule	Homo sapiens	101-104
10671232-4	2000	T cells from these newborns, when restimulated with PMA / ionomycin, demonstrated a lowered capacity to produce IFN-gamma.	Tetradecanoylphorbol Acetate	52-55	interferon gamma	Mus musculus	112-121
10662731-8	2000	TPA, a protein kinase C activator, induces cytoprotection and a persistent increase of NF-kappaB binding activity.	Tetradecanoylphorbol Acetate	0-3	nuclear factor kappa B subunit 1	Homo sapiens	87-96
10735602-7	2000	However, by in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, peripheral CD4 cells demonstrated a significant decrease of IFN-gamma-producing T helper 1 (Th1) cells and an increase of IL-4-producing T helper 2 (Th2) cells after immunotherapy.	Tetradecanoylphorbol Acetate	37-68	interferon gamma	Homo sapiens	150-159
10735602-7	2000	However, by in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, peripheral CD4 cells demonstrated a significant decrease of IFN-gamma-producing T helper 1 (Th1) cells and an increase of IL-4-producing T helper 2 (Th2) cells after immunotherapy.	Tetradecanoylphorbol Acetate	37-68	interleukin 4	Homo sapiens	212-216
10735602-7	2000	However, by in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, peripheral CD4 cells demonstrated a significant decrease of IFN-gamma-producing T helper 1 (Th1) cells and an increase of IL-4-producing T helper 2 (Th2) cells after immunotherapy.	Tetradecanoylphorbol Acetate	70-73	CD4 molecule	Homo sapiens	101-104
10735602-7	2000	However, by in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, peripheral CD4 cells demonstrated a significant decrease of IFN-gamma-producing T helper 1 (Th1) cells and an increase of IL-4-producing T helper 2 (Th2) cells after immunotherapy.	Tetradecanoylphorbol Acetate	70-73	interferon gamma	Homo sapiens	150-159
10735602-7	2000	However, by in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, peripheral CD4 cells demonstrated a significant decrease of IFN-gamma-producing T helper 1 (Th1) cells and an increase of IL-4-producing T helper 2 (Th2) cells after immunotherapy.	Tetradecanoylphorbol Acetate	70-73	interleukin 4	Homo sapiens	212-216
10685665-10	2000	Gangliosides isolated from tumor supernatants blocked the production of IL-2 and IFN-gamma in response to ionomycin plus phorbol myristate acetate stimulation.	Tetradecanoylphorbol Acetate	121-146	interleukin 2	Homo sapiens	72-76
10685665-10	2000	Gangliosides isolated from tumor supernatants blocked the production of IL-2 and IFN-gamma in response to ionomycin plus phorbol myristate acetate stimulation.	Tetradecanoylphorbol Acetate	121-146	interferon gamma	Homo sapiens	81-90
10651808-9	2000	Measurement of PKC activity in the cytosolic and membrane fractions showed that pretreatment of PMNs with ethanol increased twofold the PMA-stimulated PKC activity in the membrane fraction.	Tetradecanoylphorbol Acetate	136-139	protein kinase C alpha	Homo sapiens	151-154
10651808-11	2000	These results suggest that ethanol potentiates PMA-induced O-2 production through increasing PKC translocation and activity in PMNs.	Tetradecanoylphorbol Acetate	47-50	protein kinase C alpha	Homo sapiens	93-96
10674396-14	2000	The potential role of PKC was suggested by the observation that the well known PKC activator phorbol-12-myristate-13-acetate (PMA) potentiated the IL-4-induced 3beta-HSD activity.	Tetradecanoylphorbol Acetate	93-124	interleukin 4	Homo sapiens	147-151
10685001-7	2000	In the presence of L-NAME, PMA (1 nM) stimulation significantly increased superoxide anion generation following 3 h treatments with IL-3, TNF-alpha or IFN-gamma.	Tetradecanoylphorbol Acetate	27-30	tumor necrosis factor	Homo sapiens	138-147
10685001-7	2000	In the presence of L-NAME, PMA (1 nM) stimulation significantly increased superoxide anion generation following 3 h treatments with IL-3, TNF-alpha or IFN-gamma.	Tetradecanoylphorbol Acetate	27-30	interferon gamma	Homo sapiens	151-160
10646512-5	2000	The inhibitory effects of Ang II on lipopolysaccharide-induced expression of iNOS mRNA and protein and nitrite accumulation were mimicked by the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	178-209	angiotensinogen	Rattus norvegicus	26-32
10646512-5	2000	The inhibitory effects of Ang II on lipopolysaccharide-induced expression of iNOS mRNA and protein and nitrite accumulation were mimicked by the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	178-209	nitric oxide synthase 2	Rattus norvegicus	77-81
10646512-6	2000	Down-regulation of PKC produced by long-term treatment of astroglia with phorbol 12-myristate 13-acetate abolished the inhibitory effect of Ang II on lipopolysaccharide-stimulated expression of iNOS mRNA and nitrite accumulation.	Tetradecanoylphorbol Acetate	73-104	angiotensinogen	Rattus norvegicus	140-146
10646512-6	2000	Down-regulation of PKC produced by long-term treatment of astroglia with phorbol 12-myristate 13-acetate abolished the inhibitory effect of Ang II on lipopolysaccharide-stimulated expression of iNOS mRNA and nitrite accumulation.	Tetradecanoylphorbol Acetate	73-104	nitric oxide synthase 2	Rattus norvegicus	194-198
10737257-1	2000	The purpose of this study was to evaluate whether the mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK) signaling pathway contributes to 12-O-tertadecanoyl phorbol 13-acetate (TPA)-mediated protection from taxol-induced apoptosis of human leukemia HL-60 cells.	Tetradecanoylphorbol Acetate	203-206	mitogen-activated protein kinase kinase 7	Homo sapiens	54-124
10737257-1	2000	The purpose of this study was to evaluate whether the mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK) signaling pathway contributes to 12-O-tertadecanoyl phorbol 13-acetate (TPA)-mediated protection from taxol-induced apoptosis of human leukemia HL-60 cells.	Tetradecanoylphorbol Acetate	203-206	mitogen-activated protein kinase kinase 7	Homo sapiens	126-129
10737257-4	2000	Since TPA stimulates MEK signal transduction pathway in HL-60 cells, we postulated that MEK pathway may be playing a role in the ability of TPA to inhibit taxol-induced apoptosis.	Tetradecanoylphorbol Acetate	6-9	mitogen-activated protein kinase kinase 7	Homo sapiens	21-24
10737257-4	2000	Since TPA stimulates MEK signal transduction pathway in HL-60 cells, we postulated that MEK pathway may be playing a role in the ability of TPA to inhibit taxol-induced apoptosis.	Tetradecanoylphorbol Acetate	6-9	mitogen-activated protein kinase kinase 7	Homo sapiens	88-91
10737257-4	2000	Since TPA stimulates MEK signal transduction pathway in HL-60 cells, we postulated that MEK pathway may be playing a role in the ability of TPA to inhibit taxol-induced apoptosis.	Tetradecanoylphorbol Acetate	140-143	mitogen-activated protein kinase kinase 7	Homo sapiens	88-91
10737257-5	2000	PD098059, a specific MEK kinase inhibitor, abolished the ability of TPA to inhibit taxol-induced apoptosis.	Tetradecanoylphorbol Acetate	68-71	mitogen-activated protein kinase kinase 7	Homo sapiens	21-24
10674396-14	2000	The potential role of PKC was suggested by the observation that the well known PKC activator phorbol-12-myristate-13-acetate (PMA) potentiated the IL-4-induced 3beta-HSD activity.	Tetradecanoylphorbol Acetate	126-129	interleukin 4	Homo sapiens	147-151
10636851-1	2000	Human involucrin (hINV) mRNA level and promoter activity increase when keratinocytes are treated with the differentiating agent, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	129-165	involucrin	Homo sapiens	6-16
10673387-8	2000	Moreover, pretreatment with PMA to downregulate PKC abolished the activation of ERK.	Tetradecanoylphorbol Acetate	28-31	Eph receptor B1	Rattus norvegicus	80-83
10644756-7	2000	The inhibitory effect of PDGF on GH-induced tyrosyl phosphorylation of JAK2 and GHR is abolished by depletion of 4beta-phorbol 12-myristate 13-acetate (PMA)-sensitive PKCs with chronic PMA treatment and is severely inhibited by GF109203X, an inhibitor of PKCs.	Tetradecanoylphorbol Acetate	113-150	growth hormone 1	Homo sapiens	33-35
10644756-7	2000	The inhibitory effect of PDGF on GH-induced tyrosyl phosphorylation of JAK2 and GHR is abolished by depletion of 4beta-phorbol 12-myristate 13-acetate (PMA)-sensitive PKCs with chronic PMA treatment and is severely inhibited by GF109203X, an inhibitor of PKCs.	Tetradecanoylphorbol Acetate	152-155	growth hormone 1	Homo sapiens	33-35
10644756-7	2000	The inhibitory effect of PDGF on GH-induced tyrosyl phosphorylation of JAK2 and GHR is abolished by depletion of 4beta-phorbol 12-myristate 13-acetate (PMA)-sensitive PKCs with chronic PMA treatment and is severely inhibited by GF109203X, an inhibitor of PKCs.	Tetradecanoylphorbol Acetate	185-188	growth hormone 1	Homo sapiens	33-35
10636851-1	2000	Human involucrin (hINV) mRNA level and promoter activity increase when keratinocytes are treated with the differentiating agent, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	167-170	involucrin	Homo sapiens	6-16
10617662-2	2000	Experimentally, VEGF overexpression can be induced by the treatment of cell cultures and biological tissues with phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	137-173	vascular endothelial growth factor A	Homo sapiens	16-20
10728373-12	2000	Down-regulation of endogenous PKC by long-term exposure to phorbol 12-myristate 13-acetate decreased the superoxide anion-induced NF-kappa B activation to a basal level.	Tetradecanoylphorbol Acetate	59-90	nuclear factor kappa B subunit 1	Homo sapiens	130-140
10627456-9	2000	Down-regulation of the PKC-alpha, PKC-beta2, and PKC-epsilon expression by TPA pretreatment, or the down-regulation of PKC-alpha with a specific ribozyme, also inhibited the EPO-induced erythroid differentiation of CD34(+) cells.	Tetradecanoylphorbol Acetate	75-78	protein kinase C alpha	Homo sapiens	23-32
10625638-7	2000	Phorbol 12-myristate 13-acetate (PMA) was also a strong inducer of the promoter, indicating that PKC plays a role in expression of osteocalcin.	Tetradecanoylphorbol Acetate	0-31	bone gamma-carboxyglutamate protein	Homo sapiens	131-142
10625638-7	2000	Phorbol 12-myristate 13-acetate (PMA) was also a strong inducer of the promoter, indicating that PKC plays a role in expression of osteocalcin.	Tetradecanoylphorbol Acetate	33-36	bone gamma-carboxyglutamate protein	Homo sapiens	131-142
10625638-9	2000	Calphostin C, a selective inhibitor of PKC, decreased the PMA-, PTH-, and IGF-I-induced luciferase activity in a dose-dependent manner; a PKA inhibitor, H-89, also blocked the induction by PTH and IGF-I but not by PMA.	Tetradecanoylphorbol Acetate	58-61	insulin like growth factor 1	Homo sapiens	197-202
10625638-9	2000	Calphostin C, a selective inhibitor of PKC, decreased the PMA-, PTH-, and IGF-I-induced luciferase activity in a dose-dependent manner; a PKA inhibitor, H-89, also blocked the induction by PTH and IGF-I but not by PMA.	Tetradecanoylphorbol Acetate	214-217	insulin like growth factor 1	Homo sapiens	74-79
10617662-2	2000	Experimentally, VEGF overexpression can be induced by the treatment of cell cultures and biological tissues with phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	175-178	vascular endothelial growth factor A	Homo sapiens	16-20
10617662-6	2000	Because the VEGF promoter contains four potential AP1 binding sites, we used different promoter constructs to identify the functional site responsible for TPA induction and retinoid inhibition.	Tetradecanoylphorbol Acetate	155-158	vascular endothelial growth factor A	Homo sapiens	12-16
10838450-6	2000	Although b-FGF alone did not induce intracellular oxidative product formation by neutrophils, it enhanced H(2)O(2) production in neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	198-223	fibroblast growth factor 2	Homo sapiens	9-14
11741223-1	2000	Positively charged peptides [(Arg)7 Cys] were successfully linked to tissue-specific plasminogen activator (tPA) using cross-linking agent N-succinimidyl 3-(2-pyridyldithio) propionate.	Tetradecanoylphorbol Acetate	108-111	plasminogen activator, tissue type	Homo sapiens	69-106
11741223-2	2000	Specific amidolytic activity of this tPA/(Arg)7 Cys (termed modified tPA, mtPA) was 3900 IU/microg as compared to 5800 IU/microg of the parent tPA.	Tetradecanoylphorbol Acetate	37-40	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	74-78
10644517-4	2000	Further studies show that NaCl-inducible ERK1 and ERK2 (ERK1/2) activation is a consequence of cPKC and nPKC activation, because either downregulation with 12-O-tetradecanoylphorbol 13-acetate or selective inhibition of cPKC and nPKC by GF-109203X and rottlerin largely inhibited the stimulation of ERK1/2 phosphorylation by NaCl.	Tetradecanoylphorbol Acetate	156-192	mitogen-activated protein kinase 1	Mus musculus	50-54
11741223-2	2000	Specific amidolytic activity of this tPA/(Arg)7 Cys (termed modified tPA, mtPA) was 3900 IU/microg as compared to 5800 IU/microg of the parent tPA.	Tetradecanoylphorbol Acetate	69-72	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	74-78
11741223-2	2000	Specific amidolytic activity of this tPA/(Arg)7 Cys (termed modified tPA, mtPA) was 3900 IU/microg as compared to 5800 IU/microg of the parent tPA.	Tetradecanoylphorbol Acetate	69-72	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	74-78
11741223-6	2000	The activity of mtPA in such a complex was inhibited by heparin, and, unlike tPA, the heparin/mtPA complex did not cause statistically meaningful depletion of plasminogen, fibrinogen, and alpha2-antiplasmin in plasma.	Tetradecanoylphorbol Acetate	17-20	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	94-98
11787589-11	2000	However, the addition of N-nitro L-arginine methyl ester (L-NAME), an inducible NO synthase (iNOS) inhibitor, to the PMA-treated cells induced recovery of TAUT activity.	Tetradecanoylphorbol Acetate	117-120	nitric oxide synthase 2, inducible	Mus musculus	70-91
11787589-11	2000	However, the addition of N-nitro L-arginine methyl ester (L-NAME), an inducible NO synthase (iNOS) inhibitor, to the PMA-treated cells induced recovery of TAUT activity.	Tetradecanoylphorbol Acetate	117-120	nitric oxide synthase 2, inducible	Mus musculus	93-97
10644517-4	2000	Further studies show that NaCl-inducible ERK1 and ERK2 (ERK1/2) activation is a consequence of cPKC and nPKC activation, because either downregulation with 12-O-tetradecanoylphorbol 13-acetate or selective inhibition of cPKC and nPKC by GF-109203X and rottlerin largely inhibited the stimulation of ERK1/2 phosphorylation by NaCl.	Tetradecanoylphorbol Acetate	156-192	mitogen-activated protein kinase 1	Mus musculus	56-62
10638963-0	2000	Depletion of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances platinum drug sensitivity in human ovarian carcinoma cells.	Tetradecanoylphorbol Acetate	77-80	protein kinase C alpha	Homo sapiens	31-34
10625005-4	2000	Ketamine inhibited both the N-formyl-methionyl-leucyl-phenylalanine- and phorbol 12-myristate 13-acetate-induced up-regulation of CD18 and shedding of CD62L, determined by flow cytometry, in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	73-104	integrin subunit beta 2	Homo sapiens	130-134
11216470-6	2000	In the present study, we found that topical application of TPA onto dorsal skin of female ICR mice resulted in marked activation of epidermal NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	59-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
11216470-8	2000	Likewise, both compounds inhibited NF-kappaB and AP-1 activation in cultured human promyelocytic leukemia (HL-60) cells stimulated with TPA.	Tetradecanoylphorbol Acetate	136-139	nuclear factor kappa B subunit 1	Homo sapiens	35-44
11216470-8	2000	Likewise, both compounds inhibited NF-kappaB and AP-1 activation in cultured human promyelocytic leukemia (HL-60) cells stimulated with TPA.	Tetradecanoylphorbol Acetate	136-139	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-53
10638963-0	2000	Depletion of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances platinum drug sensitivity in human ovarian carcinoma cells.	Tetradecanoylphorbol Acetate	39-75	protein kinase C alpha	Homo sapiens	31-34
10644863-9	2000	A significant number of IFN-gamma- and IL-2-expressing T lymphocytes were only detected after 18 hours of PMA/ionomycin stimulation.	Tetradecanoylphorbol Acetate	106-109	interferon gamma	Homo sapiens	24-33
10644863-9	2000	A significant number of IFN-gamma- and IL-2-expressing T lymphocytes were only detected after 18 hours of PMA/ionomycin stimulation.	Tetradecanoylphorbol Acetate	106-109	interleukin 2	Homo sapiens	39-43
10890505-0	2000	Hydroquinone inhibits PMA-induced activation of NFkappaB in primary human CD19+ B lymphocytes.	Tetradecanoylphorbol Acetate	22-25	nuclear factor kappa B subunit 1	Homo sapiens	48-56
10638963-1	2000	Down-regulation of protein kinase C (PKC) by 12-Otetradecanoylphorbol-13-acetate (TPA) enhances the sensitivity of human ovarian carcinoma 2008 cells to various types of platinum compounds such as cisplatin (DDP), carboplatin and (-)-(R)-2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato)-platinum(II) monohydrate (DWA) by a factor of two- to threefold.	Tetradecanoylphorbol Acetate	45-80	protein kinase C alpha	Homo sapiens	37-40
10638963-1	2000	Down-regulation of protein kinase C (PKC) by 12-Otetradecanoylphorbol-13-acetate (TPA) enhances the sensitivity of human ovarian carcinoma 2008 cells to various types of platinum compounds such as cisplatin (DDP), carboplatin and (-)-(R)-2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato)-platinum(II) monohydrate (DWA) by a factor of two- to threefold.	Tetradecanoylphorbol Acetate	82-85	protein kinase C alpha	Homo sapiens	37-40
10638963-3	2000	The extent of PKC down-regulation and drug sensitization depended on the duration of TPA exposure; maximum effect was achieved with a 48 h pretreatment.	Tetradecanoylphorbol Acetate	85-88	protein kinase C alpha	Homo sapiens	14-17
10638963-6	2000	Western blot analysis revealed that whereas the expression of PKCalpha was reduced by TPA the level of PKCzeta was not affected.	Tetradecanoylphorbol Acetate	86-89	protein kinase C alpha	Homo sapiens	62-70
10638963-7	2000	These results suggest that PKCalpha is the isotype responsive to TPA in these cells and that platinum drug sensitivity can be modulated by this isoform alone.	Tetradecanoylphorbol Acetate	65-68	protein kinase C alpha	Homo sapiens	27-35
10638963-8	2000	In parallel to its effect on PKCalpha, TPA decreased cellular glutathione content by 30 +/- 3 (standard deviation (s.d.)	Tetradecanoylphorbol Acetate	39-42	protein kinase C alpha	Homo sapiens	29-37
10638963-13	2000	Although the mechanism of TPA induced sensitization is not yet fully understood, this study points to a central role for PKCalpha in modulating platinum drug sensitivity.	Tetradecanoylphorbol Acetate	26-29	protein kinase C alpha	Homo sapiens	121-129
10757128-2	2000	We previously demonstrated that application of TPA and okadaic acid induced tumor necrosis factor-alpha (TNF-alpha) gene expression in mouse skin, but that tautomycin, which is an inhibitor of PP-1 and PP-2A and not a tumor promoter on mouse skin, did not.	Tetradecanoylphorbol Acetate	47-50	tumor necrosis factor	Mus musculus	76-103
10757128-2	2000	We previously demonstrated that application of TPA and okadaic acid induced tumor necrosis factor-alpha (TNF-alpha) gene expression in mouse skin, but that tautomycin, which is an inhibitor of PP-1 and PP-2A and not a tumor promoter on mouse skin, did not.	Tetradecanoylphorbol Acetate	47-50	tumor necrosis factor	Mus musculus	105-114
10890505-6	2000	In this study, we demonstrate that 1-10 micromol/L HQ inhibits PMA/ionomycin-induced activation of NFkappaB in primary human CD19+ B cells.	Tetradecanoylphorbol Acetate	63-66	nuclear factor kappa B subunit 1	Homo sapiens	99-107
11775202-6	2000	Two agonists (angiotensin II and phenylephrine) coupled to Gq and a protein kinase C activator, phorbol 12-myristate 13-acetate (PMA) all inhibited Na(+)-Ca2+ exchange in late phase of sepsis.	Tetradecanoylphorbol Acetate	96-127	angiotensinogen	Rattus norvegicus	14-28
11775202-6	2000	Two agonists (angiotensin II and phenylephrine) coupled to Gq and a protein kinase C activator, phorbol 12-myristate 13-acetate (PMA) all inhibited Na(+)-Ca2+ exchange in late phase of sepsis.	Tetradecanoylphorbol Acetate	129-132	angiotensinogen	Rattus norvegicus	14-28
10649441-0	2000	Transcriptional regulation of fibronectin gene by phorbol myristate acetate in hepatoma cells: a negative role for NF-kappaB.	Tetradecanoylphorbol Acetate	50-75	fibronectin 1	Homo sapiens	30-41
10655565-6	2000	Other known stimuli for NK cells (IL-2 and CD16 monoclonal antibody and incubation with K562, the NK-sensitive cell line) promoted IFN-gamma and TNF-alpha production in NK cells to a lesser extent than did PMA and ionomycin stimulation.	Tetradecanoylphorbol Acetate	206-209	interleukin 2	Homo sapiens	34-38
10627292-6	2000	This possibility is corroborated by the fact that the pathway leading to the modulating activity of bcl-2 ARE is influenced by PKC, since the addition of DAG and TPA markedly attenuated the bcl-2 ARE destabilizing potential.	Tetradecanoylphorbol Acetate	162-165	BCL2 apoptosis regulator	Homo sapiens	100-105
10627292-6	2000	This possibility is corroborated by the fact that the pathway leading to the modulating activity of bcl-2 ARE is influenced by PKC, since the addition of DAG and TPA markedly attenuated the bcl-2 ARE destabilizing potential.	Tetradecanoylphorbol Acetate	162-165	proline rich transmembrane protein 2	Homo sapiens	127-130
10627292-6	2000	This possibility is corroborated by the fact that the pathway leading to the modulating activity of bcl-2 ARE is influenced by PKC, since the addition of DAG and TPA markedly attenuated the bcl-2 ARE destabilizing potential.	Tetradecanoylphorbol Acetate	162-165	BCL2 apoptosis regulator	Homo sapiens	190-195
11199339-1	2000	Production of interleukin (IL)-1 beta, IL-6 and tumor necrosis factor (TNF)-alpha by rat corneal epithelial cells in response to lipopolysaccharide and phorbol-12-myristate-13-acetate (PMA) was tested.	Tetradecanoylphorbol Acetate	152-183	interleukin 1 beta	Rattus norvegicus	14-37
11199339-1	2000	Production of interleukin (IL)-1 beta, IL-6 and tumor necrosis factor (TNF)-alpha by rat corneal epithelial cells in response to lipopolysaccharide and phorbol-12-myristate-13-acetate (PMA) was tested.	Tetradecanoylphorbol Acetate	152-183	interleukin 6	Rattus norvegicus	39-43
11199339-1	2000	Production of interleukin (IL)-1 beta, IL-6 and tumor necrosis factor (TNF)-alpha by rat corneal epithelial cells in response to lipopolysaccharide and phorbol-12-myristate-13-acetate (PMA) was tested.	Tetradecanoylphorbol Acetate	152-183	tumor necrosis factor	Rattus norvegicus	48-81
11199339-1	2000	Production of interleukin (IL)-1 beta, IL-6 and tumor necrosis factor (TNF)-alpha by rat corneal epithelial cells in response to lipopolysaccharide and phorbol-12-myristate-13-acetate (PMA) was tested.	Tetradecanoylphorbol Acetate	185-188	tumor necrosis factor	Rattus norvegicus	48-81
11268366-3	2000	Melatonin enhances IL-2 production by Jurkat cells activated by either phytohemagglutinin (PHA) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	99-124	interleukin 2	Homo sapiens	19-23
11268366-3	2000	Melatonin enhances IL-2 production by Jurkat cells activated by either phytohemagglutinin (PHA) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	126-129	interleukin 2	Homo sapiens	19-23
11426586-6	2000	Troglitazone, a PPARgamma ligand, dramatically attenuated the PMA-induced osteopontin expression.	Tetradecanoylphorbol Acetate	62-65	peroxisome proliferator activated receptor gamma	Homo sapiens	16-25
10567919-8	2000	In PC12K cells, which express only PLD2, treatment with nerve growth factor causes neurite outgrowth and increases expression of PLD2 mRNA and protein within 6-12 h. A corresponding increase is observed in membrane PLD activity and in phorbol-12-myristate-13-acetate (PMA)-stimulated PLD activity in intact cells.	Tetradecanoylphorbol Acetate	268-271	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	129-132
10649441-1	2000	The transcriptional regulation of the fibronectin (FN) gene in hepatoma cells by phorbol myristate acetate (PMA) was investigated.	Tetradecanoylphorbol Acetate	81-106	fibronectin 1	Homo sapiens	38-49
10649441-1	2000	The transcriptional regulation of the fibronectin (FN) gene in hepatoma cells by phorbol myristate acetate (PMA) was investigated.	Tetradecanoylphorbol Acetate	81-106	fibronectin 1	Homo sapiens	51-53
10649441-1	2000	The transcriptional regulation of the fibronectin (FN) gene in hepatoma cells by phorbol myristate acetate (PMA) was investigated.	Tetradecanoylphorbol Acetate	108-111	fibronectin 1	Homo sapiens	38-49
10649441-1	2000	The transcriptional regulation of the fibronectin (FN) gene in hepatoma cells by phorbol myristate acetate (PMA) was investigated.	Tetradecanoylphorbol Acetate	108-111	fibronectin 1	Homo sapiens	51-53
10649441-4	2000	Deletion analysis revealed that the sequence between positions -69 and +136 of the FN gene was responsible for the PMA induction.	Tetradecanoylphorbol Acetate	115-118	fibronectin 1	Homo sapiens	83-85
12845746-2	2000	12-O-tetradecanoyl-phorbol-13-acetate (TPA) strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH).	Tetradecanoylphorbol Acetate	0-37	growth hormone 1	Homo sapiens	64-66
12845746-2	2000	12-O-tetradecanoyl-phorbol-13-acetate (TPA) strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH).	Tetradecanoylphorbol Acetate	0-37	prolactin	Homo sapiens	71-74
12845746-2	2000	12-O-tetradecanoyl-phorbol-13-acetate (TPA) strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH).	Tetradecanoylphorbol Acetate	0-37	growth hormone 1	Homo sapiens	118-120
12845746-2	2000	12-O-tetradecanoyl-phorbol-13-acetate (TPA) strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH).	Tetradecanoylphorbol Acetate	39-42	growth hormone 1	Homo sapiens	64-66
12845746-2	2000	12-O-tetradecanoyl-phorbol-13-acetate (TPA) strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH).	Tetradecanoylphorbol Acetate	39-42	prolactin	Homo sapiens	71-74
12845746-2	2000	12-O-tetradecanoyl-phorbol-13-acetate (TPA) strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH).	Tetradecanoylphorbol Acetate	39-42	growth hormone 1	Homo sapiens	118-120
10683319-3	2000	Tetradecanoyl phorbol acetate (TPA) strongly increased the IL-8 and MCP-1 amounts in the culture supernatants of all five cell lines.	Tetradecanoylphorbol Acetate	0-29	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
10877452-1	2000	The effect of various phospholipase A2 and protein kinase inhibitors on the arachidonic acid liberation in bovine platelets induced by the protein kinase activator 12-O-tetradecanoylphorbol-13-acetate (TPA) was studied.	Tetradecanoylphorbol Acetate	164-200	plasminogen activator, tissue type	Bos taurus	202-205
10683319-3	2000	Tetradecanoyl phorbol acetate (TPA) strongly increased the IL-8 and MCP-1 amounts in the culture supernatants of all five cell lines.	Tetradecanoylphorbol Acetate	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
28008484-3	2000	By contrast, they showed the potential to up- or down-regulate the production of TNF evoked by PMA &amp; ionomycin, which was strongly dependent on the time of the stimulation.	Tetradecanoylphorbol Acetate	95-98	tumor necrosis factor	Homo sapiens	81-84
11005615-3	2000	By contrast, they showed the potential to up- or down-regulate the production of TNF evoked by PMA &amp; ionomycin, which was strongly dependent on the time of the stimulation.	Tetradecanoylphorbol Acetate	95-98	tumor necrosis factor	Homo sapiens	81-84
10798219-5	2000	Ceramide also inhibits phorbol myristate acetate-stimulated PLD.	Tetradecanoylphorbol Acetate	23-48	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	60-63
10798219-7	2000	There was an increase in PLD activity in the presence of phorbol myristate acetate in cells supplemented with 16 microM SIT compared with those supplemented with cholesterol after five days of treatment.	Tetradecanoylphorbol Acetate	57-82	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	25-28
10608863-2	1999	When phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) are topically applied, prominent epidermal thickening occurs, and exposure to interferon (IFN)-gamma promotes increased epidermal thickness producing psoriatic lesions.	Tetradecanoylphorbol Acetate	28-64	interferon gamma	Homo sapiens	149-171
11140745-1	2000	The activity of nitric oxide synthase (NOS) during the respiratory burst in phorbol-1,2-myristate-1,3-acetate (PMA) stimulated macrophages has been the topic of much debate in the literature.	Tetradecanoylphorbol Acetate	111-114	nitric oxide synthase 2	Homo sapiens	16-37
12058180-2	2000	Here, the regulatory effect of phorbol 12-myristate 13-acetate(PMA)on the several PKC isozymes in the human lung carcinoma cells A-549 was studied.	Tetradecanoylphorbol Acetate	31-62	protein kinase C alpha	Homo sapiens	82-85
12058180-2	2000	Here, the regulatory effect of phorbol 12-myristate 13-acetate(PMA)on the several PKC isozymes in the human lung carcinoma cells A-549 was studied.	Tetradecanoylphorbol Acetate	63-66	protein kinase C alpha	Homo sapiens	82-85
12058180-5	2000	Short-term treatment of cells with PMA led to the translocation of these PKC isozymes, to different extent, from cytosol to cell membrane.	Tetradecanoylphorbol Acetate	35-38	protein kinase C alpha	Homo sapiens	73-76
10601254-1	1999	The Sp1 transcription factor plays an important role in mediating the p53-independent activation of the p21(WAF1) (WAF1) promoter by phorbol 12-myristate13-acetate (PMA) in hematopoietic cells.	Tetradecanoylphorbol Acetate	133-163	tumor protein p53	Homo sapiens	70-73
10601254-1	1999	The Sp1 transcription factor plays an important role in mediating the p53-independent activation of the p21(WAF1) (WAF1) promoter by phorbol 12-myristate13-acetate (PMA) in hematopoietic cells.	Tetradecanoylphorbol Acetate	133-163	cyclin dependent kinase inhibitor 1A	Homo sapiens	104-112
10601254-1	1999	The Sp1 transcription factor plays an important role in mediating the p53-independent activation of the p21(WAF1) (WAF1) promoter by phorbol 12-myristate13-acetate (PMA) in hematopoietic cells.	Tetradecanoylphorbol Acetate	133-163	cyclin dependent kinase inhibitor 1A	Homo sapiens	108-112
10601254-1	1999	The Sp1 transcription factor plays an important role in mediating the p53-independent activation of the p21(WAF1) (WAF1) promoter by phorbol 12-myristate13-acetate (PMA) in hematopoietic cells.	Tetradecanoylphorbol Acetate	165-168	tumor protein p53	Homo sapiens	70-73
10601254-1	1999	The Sp1 transcription factor plays an important role in mediating the p53-independent activation of the p21(WAF1) (WAF1) promoter by phorbol 12-myristate13-acetate (PMA) in hematopoietic cells.	Tetradecanoylphorbol Acetate	165-168	cyclin dependent kinase inhibitor 1A	Homo sapiens	104-112
10601254-1	1999	The Sp1 transcription factor plays an important role in mediating the p53-independent activation of the p21(WAF1) (WAF1) promoter by phorbol 12-myristate13-acetate (PMA) in hematopoietic cells.	Tetradecanoylphorbol Acetate	165-168	cyclin dependent kinase inhibitor 1A	Homo sapiens	108-112
10608863-2	1999	When phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) are topically applied, prominent epidermal thickening occurs, and exposure to interferon (IFN)-gamma promotes increased epidermal thickness producing psoriatic lesions.	Tetradecanoylphorbol Acetate	66-69	interferon gamma	Homo sapiens	149-171
10608863-3	1999	While keratinocytes derived from psoriatic plaque resist apoptosis, and combination of TPA and IFN-gamma activates NF-kappaB, the molecular mechanism linking NF-kappaB activation and keratinocyte apoptosis resistance was unknown.	Tetradecanoylphorbol Acetate	87-90	nuclear factor kappa B subunit 1	Homo sapiens	115-124
10608863-3	1999	While keratinocytes derived from psoriatic plaque resist apoptosis, and combination of TPA and IFN-gamma activates NF-kappaB, the molecular mechanism linking NF-kappaB activation and keratinocyte apoptosis resistance was unknown.	Tetradecanoylphorbol Acetate	87-90	nuclear factor kappa B subunit 1	Homo sapiens	158-167
10608863-4	1999	Therefore, we examined the ability of IFN-gamma plus TPA to influence NF-kappaB activity, gene expression, and response to UV light-induced apoptosis.	Tetradecanoylphorbol Acetate	53-56	nuclear factor kappa B subunit 1	Homo sapiens	70-79
10608863-6	1999	Exposure of normal keratinocytes to IFN-gamma plus TPA produced a synergistic activation of NF-kappaB, compared with when each reagent was used individually.	Tetradecanoylphorbol Acetate	51-54	nuclear factor kappa B subunit 1	Homo sapiens	92-101
10608863-7	1999	Normal keratinocytes when exposed to IFN-gamma plus TPA acquired a resistance to UV light-induced apoptosis, which was dependent on NF-kappaB because expression of a dominant negative form of IkappaBalpha overcame the resistance.	Tetradecanoylphorbol Acetate	52-55	nuclear factor kappa B subunit 1	Homo sapiens	132-141
10608863-7	1999	Normal keratinocytes when exposed to IFN-gamma plus TPA acquired a resistance to UV light-induced apoptosis, which was dependent on NF-kappaB because expression of a dominant negative form of IkappaBalpha overcame the resistance.	Tetradecanoylphorbol Acetate	52-55	NFKB inhibitor alpha	Homo sapiens	192-204
10622742-1	1999	Treatment of U937 cells with various apoptosis-inducing agents, such as TNFalpha and beta-D-arabinofuranosylcytosine (ara-C) alone or in combination with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), bryostatin 1 or cycloheximide, causes proteolytic cleavage of protein kinase Cmu (PKCmu) between the regulatory and catalytic domain, generating a 62 kDa catalytic fragment of the kinase.	Tetradecanoylphorbol Acetate	172-208	tumor necrosis factor	Homo sapiens	72-80
10629766-4	1999	We examined the downstream consequences of PKC activation by the phorbol ester TPA and by ionophore A23187-mediated calcium influx (which experimentally correspond to DAG-mediated and calpain-mediated activation, respectively) on phosphorylation of the microtubule-associated protein tau.	Tetradecanoylphorbol Acetate	79-82	proline rich transmembrane protein 2	Homo sapiens	43-46
10574933-7	1999	Moreover, ectopic expression of cyclin D3 also prevents the induction of programmed cell death by phorbol myristate acetate and T-cell receptor activation, leading us to conclude that cyclin D3 not only plays a crucial role in progression through the G(1) phase, but is also involved in regulating apoptosis of T cells.	Tetradecanoylphorbol Acetate	98-123	cyclin D3	Homo sapiens	32-41
10574933-7	1999	Moreover, ectopic expression of cyclin D3 also prevents the induction of programmed cell death by phorbol myristate acetate and T-cell receptor activation, leading us to conclude that cyclin D3 not only plays a crucial role in progression through the G(1) phase, but is also involved in regulating apoptosis of T cells.	Tetradecanoylphorbol Acetate	98-123	cyclin D3	Homo sapiens	184-193
10571249-3	1999	We found that treatment of mesangial cells with the biologically active phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate inhibited IL-1beta induction of sPLA2-IIA mRNA, protein, and activity, whereas the inactive compound 4alpha-phorbol 12,13-didecanoate was without effect.	Tetradecanoylphorbol Acetate	72-103	interleukin 1 beta	Rattus norvegicus	149-157
10595920-6	1999	Treatment with forskolin but not phorbol 12-myristate 13-acetate (PMA) also inhibited TGF-beta1-induced apoptosis.	Tetradecanoylphorbol Acetate	66-69	transforming growth factor beta 1	Homo sapiens	86-95
10571249-3	1999	We found that treatment of mesangial cells with the biologically active phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate inhibited IL-1beta induction of sPLA2-IIA mRNA, protein, and activity, whereas the inactive compound 4alpha-phorbol 12,13-didecanoate was without effect.	Tetradecanoylphorbol Acetate	105-108	interleukin 1 beta	Rattus norvegicus	149-157
10571249-5	1999	Only after down-regulation of PKC-epsilon isoenzyme by 24-hr preincubation with PMA were we able to reconstitute the IL-1beta-induced sPLA2-IIA expression.	Tetradecanoylphorbol Acetate	80-83	interleukin 1 beta	Rattus norvegicus	117-125
10614779-1	1999	The proteolytic cleavage of a variety of membrane proteins, including pro-tumor necrosis factor alpha (pro-TNF-alpha), is induced by various reagents such as phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	158-189	tumor necrosis factor	Homo sapiens	74-101
10683762-0	1999	ERK/MAPK pathway is required for changes of cyclin D1 and B1 during phorbol 12-myristate 13-acetate-induced differentiation of K562 cells.	Tetradecanoylphorbol Acetate	68-99	mitogen-activated protein kinase 1	Homo sapiens	0-3
10683762-0	1999	ERK/MAPK pathway is required for changes of cyclin D1 and B1 during phorbol 12-myristate 13-acetate-induced differentiation of K562 cells.	Tetradecanoylphorbol Acetate	68-99	mitogen-activated protein kinase 1	Homo sapiens	4-8
10683762-3	1999	The concentrations of cyclin D1 and p21Waf1/Cip1 were dramatically increased, whereas those of cyclin B1 and cdc2 were decreased, by PMA treatment.	Tetradecanoylphorbol Acetate	133-136	cyclin dependent kinase inhibitor 1A	Homo sapiens	44-48
10683762-6	1999	Thus, it is demonstrated here that the PMA-mediated changes of cyclin D1 and B1 are the result of a persistent increase in extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) activity.	Tetradecanoylphorbol Acetate	39-42	mitogen-activated protein kinase 1	Homo sapiens	195-198
10683762-6	1999	Thus, it is demonstrated here that the PMA-mediated changes of cyclin D1 and B1 are the result of a persistent increase in extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) activity.	Tetradecanoylphorbol Acetate	39-42	mitogen-activated protein kinase 1	Homo sapiens	199-203
10618645-4	1999	Exploratory studies confirmed the anti-PKC effects of CalC, as equal molar concentrations of CalC blocked the PMA-induced translocation of PKC-alpha from the cytosolic to the membrane fraction.	Tetradecanoylphorbol Acetate	110-113	protein kinase C alpha	Homo sapiens	39-42
10618645-4	1999	Exploratory studies confirmed the anti-PKC effects of CalC, as equal molar concentrations of CalC blocked the PMA-induced translocation of PKC-alpha from the cytosolic to the membrane fraction.	Tetradecanoylphorbol Acetate	110-113	protein kinase C alpha	Homo sapiens	139-148
10614786-2	1999	Three agonists known to stimulate PLD activity, fMet-Leu-Phe (fMLP), phorbol 12-myristate 13-acetate (PMA) and V4+-OOH, induced a differential translocation of ADP-ribosylation factor (ARF), RhoA, and protein kinase Calpha (PKCalpha), all cofactors for PLD activation.	Tetradecanoylphorbol Acetate	69-100	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	34-37
10614786-2	1999	Three agonists known to stimulate PLD activity, fMet-Leu-Phe (fMLP), phorbol 12-myristate 13-acetate (PMA) and V4+-OOH, induced a differential translocation of ADP-ribosylation factor (ARF), RhoA, and protein kinase Calpha (PKCalpha), all cofactors for PLD activation.	Tetradecanoylphorbol Acetate	69-100	ras homolog family member A	Homo sapiens	191-195
10614786-2	1999	Three agonists known to stimulate PLD activity, fMet-Leu-Phe (fMLP), phorbol 12-myristate 13-acetate (PMA) and V4+-OOH, induced a differential translocation of ADP-ribosylation factor (ARF), RhoA, and protein kinase Calpha (PKCalpha), all cofactors for PLD activation.	Tetradecanoylphorbol Acetate	69-100	protein kinase C alpha	Homo sapiens	201-222
10614786-2	1999	Three agonists known to stimulate PLD activity, fMet-Leu-Phe (fMLP), phorbol 12-myristate 13-acetate (PMA) and V4+-OOH, induced a differential translocation of ADP-ribosylation factor (ARF), RhoA, and protein kinase Calpha (PKCalpha), all cofactors for PLD activation.	Tetradecanoylphorbol Acetate	69-100	protein kinase C alpha	Homo sapiens	224-232
10698257-0	1999	TPA induced expression and function of human connexin 26 by post-translational mechanisms in stably transfected neuroblastoma cells.	Tetradecanoylphorbol Acetate	0-3	gap junction protein beta 2	Homo sapiens	45-56
10698257-6	1999	Increase of Cx26 expression following TPA treatment was markedly observed using immunocytochemistry and Western blots of membrane fractions although it was not detected in Northern or Western blots of whole cells.	Tetradecanoylphorbol Acetate	38-41	gap junction protein beta 2	Homo sapiens	12-16
10698257-8	1999	These results suggest that induction of exogenous Cx26 in neuroblastoma cells by TPA treatment is controlled by post-translational mechanisms.	Tetradecanoylphorbol Acetate	81-84	gap junction protein beta 2	Homo sapiens	50-54
10528235-2	1999	The proinflammatory phorbol ester, phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), inhibits basal and cyclic adenosine monophosphate (cAMP)-stimulated NKCC1 activity in T84 intestinal epithelial cells and decreases the steady state levels of NKCC1 mRNA in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	35-66	proline rich transmembrane protein 2	Homo sapiens	90-106
10528235-2	1999	The proinflammatory phorbol ester, phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), inhibits basal and cyclic adenosine monophosphate (cAMP)-stimulated NKCC1 activity in T84 intestinal epithelial cells and decreases the steady state levels of NKCC1 mRNA in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	35-66	proline rich transmembrane protein 2	Homo sapiens	108-111
10528235-2	1999	The proinflammatory phorbol ester, phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), inhibits basal and cyclic adenosine monophosphate (cAMP)-stimulated NKCC1 activity in T84 intestinal epithelial cells and decreases the steady state levels of NKCC1 mRNA in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	68-71	proline rich transmembrane protein 2	Homo sapiens	90-106
10528235-2	1999	The proinflammatory phorbol ester, phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), inhibits basal and cyclic adenosine monophosphate (cAMP)-stimulated NKCC1 activity in T84 intestinal epithelial cells and decreases the steady state levels of NKCC1 mRNA in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	68-71	proline rich transmembrane protein 2	Homo sapiens	108-111
10570263-4	1999	PMA/ionomycin stimulation of monocytic cell lines (U937, THP-1, and MM6), but not of neutrophils, resulted in release of sCD89.	Tetradecanoylphorbol Acetate	0-3	GLI family zinc finger 2	Homo sapiens	57-62
10614779-1	1999	The proteolytic cleavage of a variety of membrane proteins, including pro-tumor necrosis factor alpha (pro-TNF-alpha), is induced by various reagents such as phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	158-189	tumor necrosis factor	Homo sapiens	107-116
10614779-1	1999	The proteolytic cleavage of a variety of membrane proteins, including pro-tumor necrosis factor alpha (pro-TNF-alpha), is induced by various reagents such as phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	191-194	tumor necrosis factor	Homo sapiens	74-101
10614779-1	1999	The proteolytic cleavage of a variety of membrane proteins, including pro-tumor necrosis factor alpha (pro-TNF-alpha), is induced by various reagents such as phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	191-194	tumor necrosis factor	Homo sapiens	107-116
10614779-4	1999	Although only hydroxamate matrix metalloproteinase (MMP) inhibitors inhibited the basal processing and release of TNF-alpha, the PMA-induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline, 3,4-dichloroisocoumarin (3,4-DCI), iodoacetamide, and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone (TPCK).	Tetradecanoylphorbol Acetate	129-132	tumor necrosis factor	Homo sapiens	167-176
10614786-3	1999	Whereas fMLP recruited all three proteins to membranes, V4+-OOH only elicited RhoA translocation and PMA induced ARF and PKCalpha translocation.	Tetradecanoylphorbol Acetate	101-104	protein kinase C alpha	Homo sapiens	121-129
10614786-2	1999	Three agonists known to stimulate PLD activity, fMet-Leu-Phe (fMLP), phorbol 12-myristate 13-acetate (PMA) and V4+-OOH, induced a differential translocation of ADP-ribosylation factor (ARF), RhoA, and protein kinase Calpha (PKCalpha), all cofactors for PLD activation.	Tetradecanoylphorbol Acetate	69-100	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	253-256
10614786-2	1999	Three agonists known to stimulate PLD activity, fMet-Leu-Phe (fMLP), phorbol 12-myristate 13-acetate (PMA) and V4+-OOH, induced a differential translocation of ADP-ribosylation factor (ARF), RhoA, and protein kinase Calpha (PKCalpha), all cofactors for PLD activation.	Tetradecanoylphorbol Acetate	102-105	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	34-37
10542377-9	1999	Furthermore, the inhibitory effect of TGFalpha on FSH-induced E2 production was reproduced by phorbol 12-myristate 13-acetate (PMA; 1.	Tetradecanoylphorbol Acetate	94-125	transforming growth factor alpha	Bos taurus	38-46
10613356-1	1999	It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells.	Tetradecanoylphorbol Acetate	34-65	interleukin 6	Homo sapiens	138-151
10613356-1	1999	It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells.	Tetradecanoylphorbol Acetate	34-65	interleukin 6	Homo sapiens	153-157
10613356-1	1999	It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells.	Tetradecanoylphorbol Acetate	34-65	interleukin 6	Homo sapiens	163-167
10613356-1	1999	It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells.	Tetradecanoylphorbol Acetate	34-65	interleukin 6 receptor	Homo sapiens	194-204
10613356-1	1999	It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells.	Tetradecanoylphorbol Acetate	67-70	interleukin 6	Homo sapiens	138-151
10613356-1	1999	It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells.	Tetradecanoylphorbol Acetate	67-70	interleukin 6	Homo sapiens	153-157
10613356-1	1999	It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells.	Tetradecanoylphorbol Acetate	67-70	interleukin 6	Homo sapiens	163-167
10613356-1	1999	It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells.	Tetradecanoylphorbol Acetate	67-70	interleukin 6 receptor	Homo sapiens	194-204
10542377-9	1999	Furthermore, the inhibitory effect of TGFalpha on FSH-induced E2 production was reproduced by phorbol 12-myristate 13-acetate (PMA; 1.	Tetradecanoylphorbol Acetate	127-130	transforming growth factor alpha	Bos taurus	38-46
10559188-5	1999	Human U937 cells were differentiated for TNF-alpha production with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	67-98	tumor necrosis factor	Homo sapiens	41-50
10600488-4	1999	Flow cytometry experiments showed that PMA produced only a slight reduction in the surface expression of EGF-R.	Tetradecanoylphorbol Acetate	39-42	epidermal growth factor receptor	Homo sapiens	105-110
10559211-6	1999	The inhibitory effect of lovastatin on PMA-stimulated leukocyte adhesion was reversed by co-incubation with geranylgeraniol, but not with farnesol, with concurrent reversal of the inhibition of protein prenylation as shown by protein RhoA geranylgeranylation.	Tetradecanoylphorbol Acetate	39-42	ras homolog family member A	Homo sapiens	234-238
10597271-3	1999	Western blot analyses of the TPA treated cells provided evidence that the endogenous PKC alpha present in these cells mediated these effects.	Tetradecanoylphorbol Acetate	29-32	protein kinase C, alpha	Mus musculus	85-94
10597286-2	1999	HGF/SF or a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced disruption of cell-cell adhesion, which was accompanied by endocytosis of both E-cadherin and c-Met.	Tetradecanoylphorbol Acetate	27-63	hepatocyte growth factor	Canis lupus familiaris	0-6
10597271-4	1999	Indeed, derivatives of the HC11 cell line that inducibly overexpress an exogenous PKC alpha or ectopic PKC beta 1 exhibited more marked growth inhibition by TPA than control cells.	Tetradecanoylphorbol Acetate	157-160	protein kinase C, alpha	Mus musculus	82-91
10597286-2	1999	HGF/SF or a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced disruption of cell-cell adhesion, which was accompanied by endocytosis of both E-cadherin and c-Met.	Tetradecanoylphorbol Acetate	65-68	hepatocyte growth factor	Canis lupus familiaris	0-6
10597271-5	1999	Immunohistochemical staining of cells following treatment with TPA revealed selective translocation of PKC alpha into the nucleus, whereas PKC beta 1 remained in the cytoplasm.	Tetradecanoylphorbol Acetate	63-66	protein kinase C, alpha	Mus musculus	103-112
10597286-7	1999	In these cell lines, the HGF- or TPA-induced coendocytosis of E-cadherin and c-Met was inhibited, but the coendocytosis of E-cadherin and c-Met in response to reduction of medium Ca2+ was not affected.	Tetradecanoylphorbol Acetate	33-36	hepatocyte growth factor	Canis lupus familiaris	25-29
10564823-1	1999	The Rbtg3 gene was isolated by PCR (polymerase chain reaction) cloning from the cDNA library of Rat1 fibroblasts that were stimulated with TPA (12-O-tetradecanoylphorbol-13-acetate) or various growth factors for 3h and was found to be a rat homologue of mouse BTG3 and human ANA genes.	Tetradecanoylphorbol Acetate	139-142	BTG anti-proliferation factor 3	Rattus norvegicus	4-9
10564823-1	1999	The Rbtg3 gene was isolated by PCR (polymerase chain reaction) cloning from the cDNA library of Rat1 fibroblasts that were stimulated with TPA (12-O-tetradecanoylphorbol-13-acetate) or various growth factors for 3h and was found to be a rat homologue of mouse BTG3 and human ANA genes.	Tetradecanoylphorbol Acetate	144-180	BTG anti-proliferation factor 3	Rattus norvegicus	4-9
10564823-7	1999	However, in all cells tested, Rbtg3 was proved to be one of the primary response genes superinduced by TPA (50ng/ml)+cycloheximide (CHX, 10 microgram/ml).	Tetradecanoylphorbol Acetate	103-106	BTG anti-proliferation factor 3	Rattus norvegicus	30-35
10578131-5	1999	5 On studying the regulation of type II AC by protein kinase C (PKC), phorbol 12-myristate-13 acetate (PMA) potentiated the PGE1-elicited cyclic AMP response, this effect being non-additive to that of LPA, suggesting that PKC activation was the common mechanism involved in AC potentiation by LPA and PMA.	Tetradecanoylphorbol Acetate	70-101	protein kinase C, alpha	Mus musculus	64-67
10558995-6	1999	In p44 MAPK-/- thymocytes, proliferation in response to activation with a monoclonal antibody to the T cell receptor in the presence of phorbol myristate acetate was severely reduced even though activation of p42 MAPK was more sustained in these cells.	Tetradecanoylphorbol Acetate	136-161	mitogen-activated protein kinase 1	Mus musculus	7-11
10555968-3	1999	TPA indicated more rapid rotational motion and more restricted angular amplitude in yeast actin.	Tetradecanoylphorbol Acetate	0-3	actin	Saccharomyces cerevisiae S288C	90-95
10564110-1	1999	Treatment of HT-29 cells with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), induces MUC2 expression.	Tetradecanoylphorbol Acetate	30-61	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	117-121
10564110-1	1999	Treatment of HT-29 cells with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), induces MUC2 expression.	Tetradecanoylphorbol Acetate	63-66	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	117-121
10697493-6	1999	The overexpression of p21Cip1 accelerated both the monocytic and granulocytic differentiation of HL60 cells triggered by TPA or DMSO, respectively.	Tetradecanoylphorbol Acetate	121-124	cyclin dependent kinase inhibitor 1A	Homo sapiens	22-29
10578131-5	1999	5 On studying the regulation of type II AC by protein kinase C (PKC), phorbol 12-myristate-13 acetate (PMA) potentiated the PGE1-elicited cyclic AMP response, this effect being non-additive to that of LPA, suggesting that PKC activation was the common mechanism involved in AC potentiation by LPA and PMA.	Tetradecanoylphorbol Acetate	70-101	protein kinase C, alpha	Mus musculus	222-225
10578131-5	1999	5 On studying the regulation of type II AC by protein kinase C (PKC), phorbol 12-myristate-13 acetate (PMA) potentiated the PGE1-elicited cyclic AMP response, this effect being non-additive to that of LPA, suggesting that PKC activation was the common mechanism involved in AC potentiation by LPA and PMA.	Tetradecanoylphorbol Acetate	103-106	protein kinase C, alpha	Mus musculus	64-67
10578131-5	1999	5 On studying the regulation of type II AC by protein kinase C (PKC), phorbol 12-myristate-13 acetate (PMA) potentiated the PGE1-elicited cyclic AMP response, this effect being non-additive to that of LPA, suggesting that PKC activation was the common mechanism involved in AC potentiation by LPA and PMA.	Tetradecanoylphorbol Acetate	103-106	protein kinase C, alpha	Mus musculus	222-225
10518804-4	1999	PMA/ionomycin treatment also mediated activation of SAPK1 (JNKs) which was inhibited by CsA.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	52-57
10547271-3	1999	It is reported that in monocytes treated with phorbol ester (PMA), translocation of PKC isoforms alpha, betaII, delta and epsilon precede cytokine synthesis.	Tetradecanoylphorbol Acetate	61-64	protein kinase C alpha	Homo sapiens	84-117
10634965-3	1999	METHODS: Basal, concanavalin A (Con A)-, and phorbol-12-myristate-13-acetate (PMA)-stimulated lymphocyte PC-1, aminopeptidase N (APN), and dipeptidylpeptidase IV (DPP IV) activities were determined in 16 patients with Type 2 diabetes before and after 3 months of metformin treatment.	Tetradecanoylphorbol Acetate	45-76	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	105-109
10674883-6	1999	Here, we demonstrate the effects of steroids/thyroids/retinoids and of activators of protein kinase A (forskolin, Forsk) and C (12-O-tetradecanoylphorbol-13-acetate, TPA), on growth and expression of c-erbB and RARs in MCF-7 breast cancer cells, which contain high levels of RAR-alpha and -gamma, and which express significant amounts of c-erbB-2 and -3.	Tetradecanoylphorbol Acetate	128-164	erb-b2 receptor tyrosine kinase 2	Homo sapiens	338-353
10497314-3	1999	We observed that the expression of the exogenous wild type MacMARCKS greatly enhanced LFA-1-mediated cell-cell adhesion in U937 cells treated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	147-178	integrin subunit beta 2	Homo sapiens	86-91
10537159-4	1999	Insulin inhibited the stimulatory effect of a high level of glucose (25 mM) and phorbol 12-myristate 13-acetate, an activator of protein kinase C) on the secretion of ANG and the expression of the ANG messenger RNA in IRPTC.	Tetradecanoylphorbol Acetate	80-111	angiotensinogen	Rattus norvegicus	167-170
10537159-4	1999	Insulin inhibited the stimulatory effect of a high level of glucose (25 mM) and phorbol 12-myristate 13-acetate, an activator of protein kinase C) on the secretion of ANG and the expression of the ANG messenger RNA in IRPTC.	Tetradecanoylphorbol Acetate	80-111	angiotensinogen	Rattus norvegicus	197-200
10497314-3	1999	We observed that the expression of the exogenous wild type MacMARCKS greatly enhanced LFA-1-mediated cell-cell adhesion in U937 cells treated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	180-183	integrin subunit beta 2	Homo sapiens	86-91
10574624-2	1999	Both the basal and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-stimulated production of KSHV/HHV-8 mature virions was strongly inhibited in genetically modified IFN-producing BCBL-1 cells as compared with parental or control transduced counterparts.	Tetradecanoylphorbol Acetate	19-56	interferon alpha 1	Homo sapiens	161-164
10580999-3	1999	We show that blocking of IL-2 synthesis by Cyclosporin A (CsA) suppressed both the Concanavalin A (Con A)- and phorbol myristate acetate (PMA)/ionomycin-induced proliferation of T cells.	Tetradecanoylphorbol Acetate	111-136	interleukin 2	Homo sapiens	25-29
10580999-3	1999	We show that blocking of IL-2 synthesis by Cyclosporin A (CsA) suppressed both the Concanavalin A (Con A)- and phorbol myristate acetate (PMA)/ionomycin-induced proliferation of T cells.	Tetradecanoylphorbol Acetate	138-141	interleukin 2	Homo sapiens	25-29
10574624-2	1999	Both the basal and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-stimulated production of KSHV/HHV-8 mature virions was strongly inhibited in genetically modified IFN-producing BCBL-1 cells as compared with parental or control transduced counterparts.	Tetradecanoylphorbol Acetate	58-61	interferon alpha 1	Homo sapiens	161-164
10574624-6	1999	TPA treatment, which did not significantly affect the viability of the parental and control BCBL-1 cells, resulted in the apoptotic death of up to 70% of the IFN-producing cell population.	Tetradecanoylphorbol Acetate	0-3	interferon alpha 1	Homo sapiens	158-161
10523655-1	1999	Downregulation of protein kinase C delta (PKC delta) by treatment with the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) transforms cells that overexpress the non-receptor class tyrosine kinase c-Src (Z. Lu et al., Mol.	Tetradecanoylphorbol Acetate	105-141	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	221-226
10629421-3	1999	Following stimulation with the protein kinase stimulator phorbol 12-myristate 13-acetate (PMA, 1 microM) there was an 2.8-fold increase of L-012 chemiluminescence, whereas incubation with angiotensin II (100 nM) did not result in a measurable increase.	Tetradecanoylphorbol Acetate	57-88	angiotensinogen	Homo sapiens	188-202
10629421-3	1999	Following stimulation with the protein kinase stimulator phorbol 12-myristate 13-acetate (PMA, 1 microM) there was an 2.8-fold increase of L-012 chemiluminescence, whereas incubation with angiotensin II (100 nM) did not result in a measurable increase.	Tetradecanoylphorbol Acetate	90-93	angiotensinogen	Homo sapiens	188-202
10523655-1	1999	Downregulation of protein kinase C delta (PKC delta) by treatment with the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) transforms cells that overexpress the non-receptor class tyrosine kinase c-Src (Z. Lu et al., Mol.	Tetradecanoylphorbol Acetate	143-146	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	221-226
10523655-6	1999	In contrast with expectations, downregulation of PKC isoforms with TPA did not transform the EGFR cells; however, treatment with EGF did transform these cells.	Tetradecanoylphorbol Acetate	67-70	protein kinase C alpha	Homo sapiens	49-52
10523655-7	1999	Since TPA downregulates all phorbol ester-responsive PKC isoforms, we examined the effects of PKC delta- and PKC alpha-specific inhibitors and the expression of dominant negative mutants for both PKC delta and alpha.	Tetradecanoylphorbol Acetate	6-9	protein kinase C alpha	Homo sapiens	53-56
10543954-5	1999	Surface plasmon resonance revealed that the affinity of initial reversible complex formation between PAI-1 and catalytically inactive Ser195--&gt;Ala variants of thrombin and thrombin-VR1(tPA) is only increased fivefold, i.e. KD is 652 and 128 nM for thrombin-S195A and thrombin-S195A-VR1(tPA), respectively.	Tetradecanoylphorbol Acetate	188-191	coagulation factor II, thrombin	Homo sapiens	175-183
10630630-10	1999	Nuclear run-on transcriptional assays on the other hand demonstrated that whereas the CFI gene is transcribed under basal conditions in Hep G2 cells, TPA induced a 3-4 fold increase in the transcription rate of CFI gene in 24 h. The transcription rate of GAPDH gene did not change, indicating that the effects were not general on gene transcription.	Tetradecanoylphorbol Acetate	150-153	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	255-260
10630630-11	1999	Transient transfections of Hep G2 cells with chloramphenicol acetyltransferase reporter gene (CAT) constructs containing a series of sequential 5" deletions of the CFI promoter and CAT assays showed that the sequence between -136 and -130, containing an AP-1 consensus sequence (TGAGTCA) was required for the TPA response.	Tetradecanoylphorbol Acetate	309-312	catalase	Homo sapiens	45-92
10630630-11	1999	Transient transfections of Hep G2 cells with chloramphenicol acetyltransferase reporter gene (CAT) constructs containing a series of sequential 5" deletions of the CFI promoter and CAT assays showed that the sequence between -136 and -130, containing an AP-1 consensus sequence (TGAGTCA) was required for the TPA response.	Tetradecanoylphorbol Acetate	309-312	catalase	Homo sapiens	94-97
10630630-13	1999	The enhancement of the activity of transfected chimeric CAT constructs by TPA was abrogated by calphostin C and by pyrrolidine dithiocarbamate (an inhibitor of NF-kappaB and AP-1 transactivation).	Tetradecanoylphorbol Acetate	74-77	catalase	Homo sapiens	56-59
10543954-2	1999	A structural and kinetical approach to establish the function of the VR1 loop of t-PA in the context of the thrombin-VR1(tPA) variant is described.	Tetradecanoylphorbol Acetate	121-124	plasminogen activator, tissue type	Homo sapiens	81-85
10543954-2	1999	A structural and kinetical approach to establish the function of the VR1 loop of t-PA in the context of the thrombin-VR1(tPA) variant is described.	Tetradecanoylphorbol Acetate	121-124	coagulation factor II, thrombin	Homo sapiens	108-116
10543954-4	1999	The contribution of a prominent charge substitution close to the active site was studied using charge neutralization variants thrombin-E39Q(c39) and thrombin-VR1(tPA)-R304Q(c39), resulting in only fourfold changes in the PAI-1 inhibition rate.	Tetradecanoylphorbol Acetate	162-165	coagulation factor II, thrombin	Homo sapiens	149-157
10543954-5	1999	Surface plasmon resonance revealed that the affinity of initial reversible complex formation between PAI-1 and catalytically inactive Ser195--&gt;Ala variants of thrombin and thrombin-VR1(tPA) is only increased fivefold, i.e. KD is 652 and 128 nM for thrombin-S195A and thrombin-S195A-VR1(tPA), respectively.	Tetradecanoylphorbol Acetate	188-191	coagulation factor II, thrombin	Homo sapiens	162-170
10543954-5	1999	Surface plasmon resonance revealed that the affinity of initial reversible complex formation between PAI-1 and catalytically inactive Ser195--&gt;Ala variants of thrombin and thrombin-VR1(tPA) is only increased fivefold, i.e. KD is 652 and 128 nM for thrombin-S195A and thrombin-S195A-VR1(tPA), respectively.	Tetradecanoylphorbol Acetate	188-191	coagulation factor II, thrombin	Homo sapiens	175-183
10595652-2	1999	Here, we further compared the actions of vanadate and phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), on induction of COX-2 with special reference to mitogen-activated protein kinases (MAPKs) in HUVEC.	Tetradecanoylphorbol Acetate	54-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
10595652-2	1999	Here, we further compared the actions of vanadate and phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), on induction of COX-2 with special reference to mitogen-activated protein kinases (MAPKs) in HUVEC.	Tetradecanoylphorbol Acetate	87-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
10595652-7	1999	These data indicate that PMA-induced and PKC-dependent expression of COX-2 requires mainly activation of ERK 1/2 among MAPKs, while activation of both ERK1/2 and p38 or possibly of all three families of MAPKs is necessary for vanadate-induced and PTK-dependent expression of COX-2.	Tetradecanoylphorbol Acetate	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
10595652-7	1999	These data indicate that PMA-induced and PKC-dependent expression of COX-2 requires mainly activation of ERK 1/2 among MAPKs, while activation of both ERK1/2 and p38 or possibly of all three families of MAPKs is necessary for vanadate-induced and PTK-dependent expression of COX-2.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase 3	Homo sapiens	105-112
10595652-7	1999	These data indicate that PMA-induced and PKC-dependent expression of COX-2 requires mainly activation of ERK 1/2 among MAPKs, while activation of both ERK1/2 and p38 or possibly of all three families of MAPKs is necessary for vanadate-induced and PTK-dependent expression of COX-2.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase 3	Homo sapiens	151-157
10595652-7	1999	These data indicate that PMA-induced and PKC-dependent expression of COX-2 requires mainly activation of ERK 1/2 among MAPKs, while activation of both ERK1/2 and p38 or possibly of all three families of MAPKs is necessary for vanadate-induced and PTK-dependent expression of COX-2.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase 1	Homo sapiens	162-165
10595652-7	1999	These data indicate that PMA-induced and PKC-dependent expression of COX-2 requires mainly activation of ERK 1/2 among MAPKs, while activation of both ERK1/2 and p38 or possibly of all three families of MAPKs is necessary for vanadate-induced and PTK-dependent expression of COX-2.	Tetradecanoylphorbol Acetate	25-28	EPH receptor A8	Homo sapiens	247-250
10595652-7	1999	These data indicate that PMA-induced and PKC-dependent expression of COX-2 requires mainly activation of ERK 1/2 among MAPKs, while activation of both ERK1/2 and p38 or possibly of all three families of MAPKs is necessary for vanadate-induced and PTK-dependent expression of COX-2.	Tetradecanoylphorbol Acetate	25-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	275-280
10543954-5	1999	Surface plasmon resonance revealed that the affinity of initial reversible complex formation between PAI-1 and catalytically inactive Ser195--&gt;Ala variants of thrombin and thrombin-VR1(tPA) is only increased fivefold, i.e. KD is 652 and 128 nM for thrombin-S195A and thrombin-S195A-VR1(tPA), respectively.	Tetradecanoylphorbol Acetate	188-191	coagulation factor II, thrombin	Homo sapiens	175-183
10543954-5	1999	Surface plasmon resonance revealed that the affinity of initial reversible complex formation between PAI-1 and catalytically inactive Ser195--&gt;Ala variants of thrombin and thrombin-VR1(tPA) is only increased fivefold, i.e. KD is 652 and 128 nM for thrombin-S195A and thrombin-S195A-VR1(tPA), respectively.	Tetradecanoylphorbol Acetate	289-292	coagulation factor II, thrombin	Homo sapiens	162-170
10543954-5	1999	Surface plasmon resonance revealed that the affinity of initial reversible complex formation between PAI-1 and catalytically inactive Ser195--&gt;Ala variants of thrombin and thrombin-VR1(tPA) is only increased fivefold, i.e. KD is 652 and 128 nM for thrombin-S195A and thrombin-S195A-VR1(tPA), respectively.	Tetradecanoylphorbol Acetate	289-292	coagulation factor II, thrombin	Homo sapiens	175-183
10543954-5	1999	Surface plasmon resonance revealed that the affinity of initial reversible complex formation between PAI-1 and catalytically inactive Ser195--&gt;Ala variants of thrombin and thrombin-VR1(tPA) is only increased fivefold, i.e. KD is 652 and 128 nM for thrombin-S195A and thrombin-S195A-VR1(tPA), respectively.	Tetradecanoylphorbol Acetate	289-292	coagulation factor II, thrombin	Homo sapiens	175-183
10543954-5	1999	Surface plasmon resonance revealed that the affinity of initial reversible complex formation between PAI-1 and catalytically inactive Ser195--&gt;Ala variants of thrombin and thrombin-VR1(tPA) is only increased fivefold, i.e. KD is 652 and 128 nM for thrombin-S195A and thrombin-S195A-VR1(tPA), respectively.	Tetradecanoylphorbol Acetate	289-292	coagulation factor II, thrombin	Homo sapiens	175-183
10529369-6	1999	These results may explain how p53 down-regulates the expression of some estrogen-responsive genes such as c-fos, c-jun, TPA, and bcl-2.	Tetradecanoylphorbol Acetate	120-123	tumor protein p53	Homo sapiens	30-33
10543954-7	1999	Hirugen allosterically decreases the rate of thrombin inhibition by PAI-1 2.5-fold and of thrombin-VR1(tPA) 20-fold, by interfering with a unimolecular step in the reaction, not by decreasing initial complex formation or by altering the stoichiometry.	Tetradecanoylphorbol Acetate	103-106	coagulation factor II, thrombin	Homo sapiens	90-98
10543954-8	1999	Finally, kinetic modeling demonstrated that acylation is the rate-limiting step in thrombin inhibition by PAI-1 (k approximately 10(-3) s(-1)) and this kinetic block is alleviated by the introduction of the tPA-VR1 into thrombin (k&gt;1 s(-1)).	Tetradecanoylphorbol Acetate	207-210	coagulation factor II, thrombin	Homo sapiens	83-91
10529371-6	1999	In addition, PD 98059 reduced fMLP-induced respiratory burst by 50%, an effect which was correlated with PLD inhibition of PLD (r = 0.981, P &lt; 0.01), and neither did PD 98059 inhibit the PLD activity and respiratory burst induced by PKC upon its direct activation by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	270-295	formyl peptide receptor 1	Homo sapiens	30-34
10543954-8	1999	Finally, kinetic modeling demonstrated that acylation is the rate-limiting step in thrombin inhibition by PAI-1 (k approximately 10(-3) s(-1)) and this kinetic block is alleviated by the introduction of the tPA-VR1 into thrombin (k&gt;1 s(-1)).	Tetradecanoylphorbol Acetate	207-210	coagulation factor II, thrombin	Homo sapiens	220-228
10816643-5	1999	In particular, beta-endorphin, a POMC peptide, has been shown to be modulated by TPA, IL-1 alpha, and ultraviolet radiation in keratinocytes.	Tetradecanoylphorbol Acetate	81-84	proopiomelanocortin	Homo sapiens	15-29
10572947-5	1999	In light of our previous results suggesting an inverse relationship between PG synthesis and FSH responsiveness in immature rat Sertoli cells, the PMA-induced upregulation of cell membrane PG, and particularly HSPG, could constitute one mechanism involved in the repression of FSH-stimulated steroidogenesis induced by PKC activation.	Tetradecanoylphorbol Acetate	147-150	syndecan 2	Rattus norvegicus	210-214
10816643-5	1999	In particular, beta-endorphin, a POMC peptide, has been shown to be modulated by TPA, IL-1 alpha, and ultraviolet radiation in keratinocytes.	Tetradecanoylphorbol Acetate	81-84	proopiomelanocortin	Homo sapiens	33-37
10537288-9	1999	Phorbol 12-myristate 13-acetate (PMA) also induced the ERK activity, but pretreatment of the cultured cells with PMA to down-regulate protein kinase C did not abolish the activation of ERK by GnRHa.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 1	Homo sapiens	55-58
10515876-4	1999	Activation of HUVEC with 100 nmol/L phorbol myristate acetate (PMA) increased THP-1 cell adhesion at shear rates less than 400 s(-1).	Tetradecanoylphorbol Acetate	36-61	GLI family zinc finger 2	Homo sapiens	78-83
10515876-4	1999	Activation of HUVEC with 100 nmol/L phorbol myristate acetate (PMA) increased THP-1 cell adhesion at shear rates less than 400 s(-1).	Tetradecanoylphorbol Acetate	63-66	GLI family zinc finger 2	Homo sapiens	78-83
10537288-9	1999	Phorbol 12-myristate 13-acetate (PMA) also induced the ERK activity, but pretreatment of the cultured cells with PMA to down-regulate protein kinase C did not abolish the activation of ERK by GnRHa.	Tetradecanoylphorbol Acetate	33-36	mitogen-activated protein kinase 1	Homo sapiens	55-58
10537288-9	1999	Phorbol 12-myristate 13-acetate (PMA) also induced the ERK activity, but pretreatment of the cultured cells with PMA to down-regulate protein kinase C did not abolish the activation of ERK by GnRHa.	Tetradecanoylphorbol Acetate	113-116	mitogen-activated protein kinase 1	Homo sapiens	55-58
10514454-9	1999	However, it inhibited TPA-induced AP-1 activity in ZR75-1 cells and the constitutive AP-1 activity in H460 and H292 cells.	Tetradecanoylphorbol Acetate	22-25	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-38
10510401-12	1999	We conclude that conventional PKC isoforms (PKC-alpha and/or PKC-betaII) may regulate PMA-stimulated cytoskeletal association and activation of NADPH oxidase.	Tetradecanoylphorbol Acetate	86-89	protein kinase C alpha	Homo sapiens	30-33
10510401-12	1999	We conclude that conventional PKC isoforms (PKC-alpha and/or PKC-betaII) may regulate PMA-stimulated cytoskeletal association and activation of NADPH oxidase.	Tetradecanoylphorbol Acetate	86-89	protein kinase C alpha	Homo sapiens	44-53
10514454-10	1999	Thus, trans-RA modulates TPA activity through its interaction through TPA-induced JNK/AP-1 pathway but not TPA-induced ERK/p21(WAF1) pathway.	Tetradecanoylphorbol Acetate	25-28	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-90
10514454-10	1999	Thus, trans-RA modulates TPA activity through its interaction through TPA-induced JNK/AP-1 pathway but not TPA-induced ERK/p21(WAF1) pathway.	Tetradecanoylphorbol Acetate	70-73	mitogen-activated protein kinase 8	Homo sapiens	82-85
10514454-10	1999	Thus, trans-RA modulates TPA activity through its interaction through TPA-induced JNK/AP-1 pathway but not TPA-induced ERK/p21(WAF1) pathway.	Tetradecanoylphorbol Acetate	70-73	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-90
10514454-10	1999	Thus, trans-RA modulates TPA activity through its interaction through TPA-induced JNK/AP-1 pathway but not TPA-induced ERK/p21(WAF1) pathway.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase 8	Homo sapiens	82-85
10514454-10	1999	Thus, trans-RA modulates TPA activity through its interaction through TPA-induced JNK/AP-1 pathway but not TPA-induced ERK/p21(WAF1) pathway.	Tetradecanoylphorbol Acetate	70-73	mitogen-activated protein kinase 8	Homo sapiens	82-85
10514454-10	1999	Thus, trans-RA modulates TPA activity through its interaction through TPA-induced JNK/AP-1 pathway but not TPA-induced ERK/p21(WAF1) pathway.	Tetradecanoylphorbol Acetate	70-73	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-90
10523856-10	1999	The MEK inhibitor PD 098059, as well as the PKC inhibitors, completely blocked TPA-mediated ERK activation.	Tetradecanoylphorbol Acetate	79-82	mitogen-activated protein kinase 1	Homo sapiens	92-95
10523856-1	1999	The MDR1 gene encoding the multidrug pump P-glycoprotein is transcriptionally activated in response to diverse extracellular stimuli, including the tumor promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	179-215	ATP binding cassette subfamily B member 1	Homo sapiens	4-8
10523856-11	1999	However, under identical conditions, MDR1 induction by TPA was completely unaffected by PD 098059.	Tetradecanoylphorbol Acetate	55-58	ATP binding cassette subfamily B member 1	Homo sapiens	37-41
10523856-1	1999	The MDR1 gene encoding the multidrug pump P-glycoprotein is transcriptionally activated in response to diverse extracellular stimuli, including the tumor promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	217-220	ATP binding cassette subfamily B member 1	Homo sapiens	4-8
10523856-3	1999	Downstream of protein kinase C (PKC), the effects of TPA are often mediated by the Raf-1/MEK/ERK mitogen-activated protein kinase (MAPK) cascade, and Raf-1 has been implicated in MDR1 induction by serum and mitogens.	Tetradecanoylphorbol Acetate	53-56	protein kinase C alpha	Homo sapiens	32-35
10523856-13	1999	These data demonstrate that MDR1 induction by TPA occurs via a PKC-dependent mechanism that operates independently of ERK, p38 or JNK pathways, and thus have important implications for understanding the mechanisms of MDR1 induction by extracellular stimuli.	Tetradecanoylphorbol Acetate	46-49	ATP binding cassette subfamily B member 1	Homo sapiens	28-32
10523856-3	1999	Downstream of protein kinase C (PKC), the effects of TPA are often mediated by the Raf-1/MEK/ERK mitogen-activated protein kinase (MAPK) cascade, and Raf-1 has been implicated in MDR1 induction by serum and mitogens.	Tetradecanoylphorbol Acetate	53-56	mitogen-activated protein kinase kinase 7	Homo sapiens	89-92
10523856-13	1999	These data demonstrate that MDR1 induction by TPA occurs via a PKC-dependent mechanism that operates independently of ERK, p38 or JNK pathways, and thus have important implications for understanding the mechanisms of MDR1 induction by extracellular stimuli.	Tetradecanoylphorbol Acetate	46-49	protein kinase C alpha	Homo sapiens	63-66
10523856-3	1999	Downstream of protein kinase C (PKC), the effects of TPA are often mediated by the Raf-1/MEK/ERK mitogen-activated protein kinase (MAPK) cascade, and Raf-1 has been implicated in MDR1 induction by serum and mitogens.	Tetradecanoylphorbol Acetate	53-56	mitogen-activated protein kinase 1	Homo sapiens	93-96
10523856-3	1999	Downstream of protein kinase C (PKC), the effects of TPA are often mediated by the Raf-1/MEK/ERK mitogen-activated protein kinase (MAPK) cascade, and Raf-1 has been implicated in MDR1 induction by serum and mitogens.	Tetradecanoylphorbol Acetate	53-56	mitogen-activated protein kinase 1	Homo sapiens	131-135
10523856-3	1999	Downstream of protein kinase C (PKC), the effects of TPA are often mediated by the Raf-1/MEK/ERK mitogen-activated protein kinase (MAPK) cascade, and Raf-1 has been implicated in MDR1 induction by serum and mitogens.	Tetradecanoylphorbol Acetate	53-56	ATP binding cassette subfamily B member 1	Homo sapiens	179-183
10523856-4	1999	Therefore, we examined the potential role of MAPK activation in TPA-mediated MDR1 induction in human leukemia K562 cells.	Tetradecanoylphorbol Acetate	64-67	mitogen-activated protein kinase 1	Homo sapiens	45-49
10523856-4	1999	Therefore, we examined the potential role of MAPK activation in TPA-mediated MDR1 induction in human leukemia K562 cells.	Tetradecanoylphorbol Acetate	64-67	ATP binding cassette subfamily B member 1	Homo sapiens	77-81
10523856-13	1999	These data demonstrate that MDR1 induction by TPA occurs via a PKC-dependent mechanism that operates independently of ERK, p38 or JNK pathways, and thus have important implications for understanding the mechanisms of MDR1 induction by extracellular stimuli.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 1	Homo sapiens	118-121
10523856-5	1999	MDR1 mRNA expression was significantly increased by TPA in the concentration range of 4 - 100 nM, with a maximal response 5 - 10 h after TPA addition.	Tetradecanoylphorbol Acetate	52-55	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
10523856-5	1999	MDR1 mRNA expression was significantly increased by TPA in the concentration range of 4 - 100 nM, with a maximal response 5 - 10 h after TPA addition.	Tetradecanoylphorbol Acetate	137-140	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
10523856-13	1999	These data demonstrate that MDR1 induction by TPA occurs via a PKC-dependent mechanism that operates independently of ERK, p38 or JNK pathways, and thus have important implications for understanding the mechanisms of MDR1 induction by extracellular stimuli.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 14	Homo sapiens	123-126
10523856-6	1999	TPA-mediated MDR1 induction was inhibited by several PKC inhibitors including staurosporine, H7 and calphostin C.	Tetradecanoylphorbol Acetate	0-3	ATP binding cassette subfamily B member 1	Homo sapiens	13-17
10523856-6	1999	TPA-mediated MDR1 induction was inhibited by several PKC inhibitors including staurosporine, H7 and calphostin C.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	53-56
10523856-13	1999	These data demonstrate that MDR1 induction by TPA occurs via a PKC-dependent mechanism that operates independently of ERK, p38 or JNK pathways, and thus have important implications for understanding the mechanisms of MDR1 induction by extracellular stimuli.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 8	Homo sapiens	130-133
10523856-7	1999	TPA stimulated the subcellular translocation of PKCalpha from the cytosol to the membrane and nucleus but did not affect other PKC isozymes.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	48-56
10523856-13	1999	These data demonstrate that MDR1 induction by TPA occurs via a PKC-dependent mechanism that operates independently of ERK, p38 or JNK pathways, and thus have important implications for understanding the mechanisms of MDR1 induction by extracellular stimuli.	Tetradecanoylphorbol Acetate	46-49	ATP binding cassette subfamily B member 1	Homo sapiens	217-221
10523856-7	1999	TPA stimulated the subcellular translocation of PKCalpha from the cytosol to the membrane and nucleus but did not affect other PKC isozymes.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	48-51
10523861-1	1999	Activator protein 1 (AP-1) transactivation and ornithine decarboxylase (ODC) activity have been established as essential downstream effectors of mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	175-211	promotion susceptibility QTL 1	Mus musculus	213-216
10523856-8	1999	TPA also activated the Raf1/MEK/ERK cascade and activated another MAPK member, p38, but not JNK.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 7	Homo sapiens	28-31
10523856-8	1999	TPA also activated the Raf1/MEK/ERK cascade and activated another MAPK member, p38, but not JNK.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	32-35
10523856-8	1999	TPA also activated the Raf1/MEK/ERK cascade and activated another MAPK member, p38, but not JNK.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	66-70
10519505-9	1999	Both ERKs were also activated by 4beta-phorbol 12-myristate 13-acetate, an activator of protein kinase C, and fluoroaluminate (AlF4-), respectively, but procaine did not affect ERK activation induced by these two substances.	Tetradecanoylphorbol Acetate	33-70	Eph receptor B1	Rattus norvegicus	5-8
10523856-8	1999	TPA also activated the Raf1/MEK/ERK cascade and activated another MAPK member, p38, but not JNK.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	79-82
10523856-8	1999	TPA also activated the Raf1/MEK/ERK cascade and activated another MAPK member, p38, but not JNK.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	92-95
10523856-9	1999	In order to determine the potential role of MAPKs in MDR1 induction by TPA, specific inhibitors were utilized.	Tetradecanoylphorbol Acetate	71-74	ATP binding cassette subfamily B member 1	Homo sapiens	53-57
10523856-10	1999	The MEK inhibitor PD 098059, as well as the PKC inhibitors, completely blocked TPA-mediated ERK activation.	Tetradecanoylphorbol Acetate	79-82	mitogen-activated protein kinase kinase 7	Homo sapiens	4-7
10523856-10	1999	The MEK inhibitor PD 098059, as well as the PKC inhibitors, completely blocked TPA-mediated ERK activation.	Tetradecanoylphorbol Acetate	79-82	protein kinase C alpha	Homo sapiens	44-47
10529207-9	1999	After phorbol ester (TPA) application, PKC activation was characterized by biexponential kinetics, including a rapid phase completed within 5 min and a slow phase lasting at least 30 min, which reflected several activation steps.	Tetradecanoylphorbol Acetate	21-24	protein kinase C alpha	Homo sapiens	39-42
10529207-10	1999	Two different binding sites for TPA were revealed on membrane-associated PKCalpha (EC(50) = 31 +/- 12 and 580 +/- 170 nM), and their modulation by phosphatidylserine and Ca2+ was characterized.	Tetradecanoylphorbol Acetate	32-35	protein kinase C alpha	Homo sapiens	73-81
10529207-12	1999	Our study shows that binding of low concentrations of TPA triggers conformational changes in the soluble PKCalpha, which affect the microenvironment of its catalytic domain.	Tetradecanoylphorbol Acetate	54-57	protein kinase C alpha	Homo sapiens	105-113
10547071-10	1999	In addition to OM, we showed that the p53 protein expression in MCF-7 cells was also decreased by phorbol 12-myristate 13-acetate treatment (PMA).	Tetradecanoylphorbol Acetate	98-129	tumor protein p53	Homo sapiens	38-41
10540223-10	1999	In subcellular fractions, Rac2 was found to translocate, along with p47phox and p67phox, from cytosol to plasma membrane-associated fractions following phorbol myristate acetate stimulation, while RhoGDI remained within cytosolic fractions.	Tetradecanoylphorbol Acetate	152-177	Rac family small GTPase 2	Homo sapiens	26-30
10525317-6	1999	Compared to controls, rheumatoid arthritis patients, treated with salazopyrin, showed an increased number of IL-2-producing T-helper and T-suppressor/cytotoxic lymphocytes after in vitro stimulation with PMA and ionomycin (P=0.01).	Tetradecanoylphorbol Acetate	204-207	interleukin 2	Homo sapiens	109-113
10583506-11	1999	Addition of 12-O-tetradecanoylphorbol-13-acetate to the cells formed a tight junction-like structure where nectin and afadin, but not cadherin, accumulated.	Tetradecanoylphorbol Acetate	12-48	afadin, adherens junction formation factor	Mus musculus	118-124
10506935-9	1999	This localized modulation of cell-cell adhesion at the lower portion of the cells is associated with increased tyrosine phosphorylation of the E-cadherin-catenin complex in TPA-induced cohort migration and with reduced alpha-catenin complexed with E-cadherin in HGF/SF-induced cohort migration.	Tetradecanoylphorbol Acetate	173-176	cadherin 1	Homo sapiens	143-153
10506935-9	1999	This localized modulation of cell-cell adhesion at the lower portion of the cells is associated with increased tyrosine phosphorylation of the E-cadherin-catenin complex in TPA-induced cohort migration and with reduced alpha-catenin complexed with E-cadherin in HGF/SF-induced cohort migration.	Tetradecanoylphorbol Acetate	173-176	cadherin 1	Homo sapiens	248-258
10603431-4	1999	These results suggest that up-regulated tPA may contribute to the degradation of PSA-NCAM.	Tetradecanoylphorbol Acetate	40-43	neural cell adhesion molecule 1	Mus musculus	85-89
10497185-0	1999	12-O-tetradecanoylphorbol-13-acetate-induced apoptosis is mediated by tumor necrosis factor alpha in human monocytic U937 cells.	Tetradecanoylphorbol Acetate	0-36	tumor necrosis factor	Homo sapiens	70-97
10497185-4	1999	Further studies showed that TPA increased production of tumor necrosis factor-alpha (TNFalpha) in U937 cells, and exogenously added TNFalpha induced apoptosis.	Tetradecanoylphorbol Acetate	28-31	tumor necrosis factor	Homo sapiens	56-83
10497185-4	1999	Further studies showed that TPA increased production of tumor necrosis factor-alpha (TNFalpha) in U937 cells, and exogenously added TNFalpha induced apoptosis.	Tetradecanoylphorbol Acetate	28-31	tumor necrosis factor	Homo sapiens	85-93
10497185-5	1999	Moreover, the induction of apoptosis by TPA was blocked by anti-TNFalpha antibody.	Tetradecanoylphorbol Acetate	40-43	tumor necrosis factor	Homo sapiens	64-72
10497185-9	1999	Our results indicate that TPA induces apoptosis, at least in part, through a pathway that requires endogenous production of TNFalpha in U937 cells.	Tetradecanoylphorbol Acetate	26-29	tumor necrosis factor	Homo sapiens	124-132
10497185-10	1999	Our data also suggest that the induction of apoptosis by TPA occurs through activation of protein kinase C and mitogen-activated protein kinase and TNFalpha is an autocrine-stimulating factor for the induction of apoptosis in these cells.	Tetradecanoylphorbol Acetate	57-60	tumor necrosis factor	Homo sapiens	148-156
10504298-6	1999	However, a single topical treatment with the PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a striking inflammatory response characterized by edema and extensive epidermal infiltration of neutrophils that formed intraepidermal microabscesses in the epidermis.	Tetradecanoylphorbol Acetate	60-96	protein kinase C, alpha	Mus musculus	45-48
10504298-6	1999	However, a single topical treatment with the PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a striking inflammatory response characterized by edema and extensive epidermal infiltration of neutrophils that formed intraepidermal microabscesses in the epidermis.	Tetradecanoylphorbol Acetate	98-101	protein kinase C, alpha	Mus musculus	45-48
10504298-7	1999	Compared to TPA-treated wild-type mice, the epidermis of TPA-treated K5-PKCalpha mice displayed increased expression of cyclooxygenase-2 (COX-2), the neutrophil chemotactic factor macrophage inflammatory protein-2 (MIP-2) mRNA and the proinflammatory cytokine TNFalpha mRNA but not IL-6 or IL-1alpha mRNA.	Tetradecanoylphorbol Acetate	57-60	protein kinase C, alpha	Mus musculus	72-80
10504298-7	1999	Compared to TPA-treated wild-type mice, the epidermis of TPA-treated K5-PKCalpha mice displayed increased expression of cyclooxygenase-2 (COX-2), the neutrophil chemotactic factor macrophage inflammatory protein-2 (MIP-2) mRNA and the proinflammatory cytokine TNFalpha mRNA but not IL-6 or IL-1alpha mRNA.	Tetradecanoylphorbol Acetate	57-60	chemokine (C-X-C motif) ligand 2	Mus musculus	180-213
10504298-7	1999	Compared to TPA-treated wild-type mice, the epidermis of TPA-treated K5-PKCalpha mice displayed increased expression of cyclooxygenase-2 (COX-2), the neutrophil chemotactic factor macrophage inflammatory protein-2 (MIP-2) mRNA and the proinflammatory cytokine TNFalpha mRNA but not IL-6 or IL-1alpha mRNA.	Tetradecanoylphorbol Acetate	57-60	chemokine (C-X-C motif) ligand 2	Mus musculus	215-220
10504298-7	1999	Compared to TPA-treated wild-type mice, the epidermis of TPA-treated K5-PKCalpha mice displayed increased expression of cyclooxygenase-2 (COX-2), the neutrophil chemotactic factor macrophage inflammatory protein-2 (MIP-2) mRNA and the proinflammatory cytokine TNFalpha mRNA but not IL-6 or IL-1alpha mRNA.	Tetradecanoylphorbol Acetate	57-60	tumor necrosis factor	Mus musculus	260-268
10504298-7	1999	Compared to TPA-treated wild-type mice, the epidermis of TPA-treated K5-PKCalpha mice displayed increased expression of cyclooxygenase-2 (COX-2), the neutrophil chemotactic factor macrophage inflammatory protein-2 (MIP-2) mRNA and the proinflammatory cytokine TNFalpha mRNA but not IL-6 or IL-1alpha mRNA.	Tetradecanoylphorbol Acetate	57-60	interleukin 6	Mus musculus	282-286
10541434-3	1999	However, several agents known to activate NF-kappaB, such as phorbol 12-myristate 13-acetate (PMA) and TNFalpha, result in decreased expression of type I collagen.	Tetradecanoylphorbol Acetate	61-92	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	42-51
10551153-10	1999	GM-CSF (50 IU/ml) also significantly increased IL-8 production from 2-7 days of treatment of THP-1 cells when supplemented with a positive control, phorbol-12-myristate-13 acetate (PMA), as compared to PMA treatment alone.	Tetradecanoylphorbol Acetate	148-179	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
10498893-2	1999	In this study we show that insulin-like growth factor 1 (IGF-1) and tetradecanoyl phorbol acetate (TPA) induce RARbeta gene expression in neuroblastoma SH-SY5Y cells.	Tetradecanoylphorbol Acetate	68-97	retinoic acid receptor beta	Homo sapiens	111-118
10520184-7	1999	The production of IFN-gamma and IL-4 following CD3-CD28 stimulation of RA PB MNC correlated significantly in a ratio 1 : 1 with production following ionomycin-PMA stimulation.	Tetradecanoylphorbol Acetate	159-162	interferon gamma	Homo sapiens	18-27
10520184-7	1999	The production of IFN-gamma and IL-4 following CD3-CD28 stimulation of RA PB MNC correlated significantly in a ratio 1 : 1 with production following ionomycin-PMA stimulation.	Tetradecanoylphorbol Acetate	159-162	interleukin 4	Homo sapiens	32-36
10523838-3	1999	Here we found that a protein kinase C (PKC) activator phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) promoted cell death in human gastric cancer cell lines MKN45 and MKN74 only when they lost anchorage.	Tetradecanoylphorbol Acetate	68-105	protein kinase C alpha	Homo sapiens	39-42
10523838-3	1999	Here we found that a protein kinase C (PKC) activator phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) promoted cell death in human gastric cancer cell lines MKN45 and MKN74 only when they lost anchorage.	Tetradecanoylphorbol Acetate	107-110	protein kinase C alpha	Homo sapiens	39-42
10523838-4	1999	Loss of anchorage slightly increased enzymatic activity of PKCalpha, and an addition of TPA promoted cell death with further increase of PKCalpha activity, but not PKCbeta in MKN45 cells, implicating an involvement of PKCalpha in anoikis.	Tetradecanoylphorbol Acetate	88-91	protein kinase C alpha	Homo sapiens	137-145
10523838-4	1999	Loss of anchorage slightly increased enzymatic activity of PKCalpha, and an addition of TPA promoted cell death with further increase of PKCalpha activity, but not PKCbeta in MKN45 cells, implicating an involvement of PKCalpha in anoikis.	Tetradecanoylphorbol Acetate	88-91	protein kinase C alpha	Homo sapiens	137-145
10498893-2	1999	In this study we show that insulin-like growth factor 1 (IGF-1) and tetradecanoyl phorbol acetate (TPA) induce RARbeta gene expression in neuroblastoma SH-SY5Y cells.	Tetradecanoylphorbol Acetate	99-102	retinoic acid receptor beta	Homo sapiens	111-118
10493498-3	1999	In TNF-/- mice treated with DMBA plus TPA, tumor onset was delayed 4 weeks, and the time to development of small tumors in 100% of mice was 9 weeks later than that seen in TNF+/+ CD-1 mice.	Tetradecanoylphorbol Acetate	38-41	tumor necrosis factor	Mus musculus	3-6
10493498-4	1999	The average number of tumors in TPA-treated TNF-/- mice was 2.8, compared with 11.8 for TNF+/+ CD-1 mice.	Tetradecanoylphorbol Acetate	32-35	tumor necrosis factor	Mus musculus	44-47
10493498-6	1999	A single application of TPA and okadaic acid increased IL-1alpha and IL-1beta gene expression in TNF-/- mice.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 beta	Mus musculus	69-77
10493498-6	1999	A single application of TPA and okadaic acid increased IL-1alpha and IL-1beta gene expression in TNF-/- mice.	Tetradecanoylphorbol Acetate	24-27	tumor necrosis factor	Mus musculus	97-100
10464284-5	1999	Concomitant with TPA-induced CD44 cleavage, TPA treatment induces redistribution of CD44 and ERM proteins (ezrin, radixin, and moesin) to newly generated membrane ruffling areas.	Tetradecanoylphorbol Acetate	17-20	moesin	Homo sapiens	127-133
10580845-6	1999	This inhibition by medroxyprogesterone also occurs when cells are stimulated to produce IL-1alpha by PMA rather than serotonin.	Tetradecanoylphorbol Acetate	101-104	interleukin 1 alpha	Rattus norvegicus	88-97
10464293-4	1999	The endogenous VIP gene and a 5.2-kilobase pair (kb) VIP-luciferase reporter gene, are up-regulated by phorbol 12-myristate 13-acetate (PMA) in SK-N-SH neuroblastoma cells.	Tetradecanoylphorbol Acetate	136-139	vasoactive intestinal peptide	Homo sapiens	53-56
10464284-5	1999	Concomitant with TPA-induced CD44 cleavage, TPA treatment induces redistribution of CD44 and ERM proteins (ezrin, radixin, and moesin) to newly generated membrane ruffling areas.	Tetradecanoylphorbol Acetate	44-47	moesin	Homo sapiens	127-133
10464293-4	1999	The endogenous VIP gene and a 5.2-kilobase pair (kb) VIP-luciferase reporter gene, are up-regulated by phorbol 12-myristate 13-acetate (PMA) in SK-N-SH neuroblastoma cells.	Tetradecanoylphorbol Acetate	103-134	vasoactive intestinal peptide	Homo sapiens	15-18
10464293-4	1999	The endogenous VIP gene and a 5.2-kilobase pair (kb) VIP-luciferase reporter gene, are up-regulated by phorbol 12-myristate 13-acetate (PMA) in SK-N-SH neuroblastoma cells.	Tetradecanoylphorbol Acetate	103-134	vasoactive intestinal peptide	Homo sapiens	53-56
10464293-4	1999	The endogenous VIP gene and a 5.2-kilobase pair (kb) VIP-luciferase reporter gene, are up-regulated by phorbol 12-myristate 13-acetate (PMA) in SK-N-SH neuroblastoma cells.	Tetradecanoylphorbol Acetate	136-139	vasoactive intestinal peptide	Homo sapiens	15-18
10484520-7	1999	The stimulatory effects of LDL on collagen gene regulation in HMC were blocked by the inhibition of PKC using GF-109203X (GFX) or the downregulation of PKC using phorbol myristate acetate.	Tetradecanoylphorbol Acetate	162-187	protein kinase C alpha	Homo sapiens	152-155
10524248-0	1999	Transcriptional induction of p69 2"-5"-oligoadenylate synthetase by interferon-alpha is stimulated by 12-O-tetradecanoyl phorbol-13-acetate through IRF/ISRE binding motifs.	Tetradecanoylphorbol Acetate	102-139	tripartite motif containing 63	Homo sapiens	148-151
10524248-3	1999	The region from -366 to -117 bp, relative to the translational start site, contains three sequence motifs that resemble interferon stimulated response elements/interferon regulatory factor elements (ISRE/IRF-E), which are required for stimulation of the IFN-alpha-response by the PKC activator, 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	295-332	tripartite motif containing 63	Homo sapiens	204-207
10524248-3	1999	The region from -366 to -117 bp, relative to the translational start site, contains three sequence motifs that resemble interferon stimulated response elements/interferon regulatory factor elements (ISRE/IRF-E), which are required for stimulation of the IFN-alpha-response by the PKC activator, 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	295-332	interferon alpha 1	Homo sapiens	254-263
10524248-3	1999	The region from -366 to -117 bp, relative to the translational start site, contains three sequence motifs that resemble interferon stimulated response elements/interferon regulatory factor elements (ISRE/IRF-E), which are required for stimulation of the IFN-alpha-response by the PKC activator, 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	334-337	tripartite motif containing 63	Homo sapiens	204-207
10524248-3	1999	The region from -366 to -117 bp, relative to the translational start site, contains three sequence motifs that resemble interferon stimulated response elements/interferon regulatory factor elements (ISRE/IRF-E), which are required for stimulation of the IFN-alpha-response by the PKC activator, 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	334-337	interferon alpha 1	Homo sapiens	254-263
10524248-5	1999	Likewise, introduction of point mutations into either of these IRF-Es decreases stimulation of IFN-alpha induction by TPA and constructs containing point mutations in both upstream IRF-Es are nonresponsive to TPA.	Tetradecanoylphorbol Acetate	118-121	tripartite motif containing 63	Homo sapiens	63-66
10524248-5	1999	Likewise, introduction of point mutations into either of these IRF-Es decreases stimulation of IFN-alpha induction by TPA and constructs containing point mutations in both upstream IRF-Es are nonresponsive to TPA.	Tetradecanoylphorbol Acetate	118-121	interferon alpha 1	Homo sapiens	95-104
10484455-4	1999	Significant enhancement of [(3)H]thymidine incorporation in HASM cultures was observed only by treatment with agents (epidermal growth factor, platelet-derived growth factor, thrombin, and phorbol 12-myristate 13-acetate) that promoted a strong and sustained activation of p42/p44 MAPK.	Tetradecanoylphorbol Acetate	189-220	mitogen-activated protein kinase 3	Homo sapiens	277-285
10484519-2	1999	In the present study, we demonstrated that the COX-2-selective inhibitor, NS-398, prevented tumor necrosis factor-alpha (TNF)- and phorbol myristate acetate (PMA)-mediated increases in PGE(2) production by cultured MTAL cells.	Tetradecanoylphorbol Acetate	131-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
10484519-2	1999	In the present study, we demonstrated that the COX-2-selective inhibitor, NS-398, prevented tumor necrosis factor-alpha (TNF)- and phorbol myristate acetate (PMA)-mediated increases in PGE(2) production by cultured MTAL cells.	Tetradecanoylphorbol Acetate	158-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
10449199-5	1999	These results suggest that PGHS-2 overexpression induced by TPA could be induced by AA and/or AA metabolite release by leukocyte infiltrated during the inflammatory process.	Tetradecanoylphorbol Acetate	60-63	prostaglandin-endoperoxide synthase 2	Homo sapiens	27-33
10625951-7	1999	Furthermore, we have investigated the role of PKC and its isozymes in the synergistic induction of PI-3 K by TPA and insulin and found that bisindolylmaleimide, a PKC inhibitor, inhibits TPA-induced PI-3 K. Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K activity.	Tetradecanoylphorbol Acetate	109-112	protein kinase C alpha	Homo sapiens	46-49
10625951-7	1999	Furthermore, we have investigated the role of PKC and its isozymes in the synergistic induction of PI-3 K by TPA and insulin and found that bisindolylmaleimide, a PKC inhibitor, inhibits TPA-induced PI-3 K. Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K activity.	Tetradecanoylphorbol Acetate	109-112	protein kinase C alpha	Homo sapiens	163-166
10625951-7	1999	Furthermore, we have investigated the role of PKC and its isozymes in the synergistic induction of PI-3 K by TPA and insulin and found that bisindolylmaleimide, a PKC inhibitor, inhibits TPA-induced PI-3 K. Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K activity.	Tetradecanoylphorbol Acetate	109-112	protein kinase C alpha	Homo sapiens	284-293
10625951-7	1999	Furthermore, we have investigated the role of PKC and its isozymes in the synergistic induction of PI-3 K by TPA and insulin and found that bisindolylmaleimide, a PKC inhibitor, inhibits TPA-induced PI-3 K. Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K activity.	Tetradecanoylphorbol Acetate	187-190	protein kinase C alpha	Homo sapiens	46-49
10625951-7	1999	Furthermore, we have investigated the role of PKC and its isozymes in the synergistic induction of PI-3 K by TPA and insulin and found that bisindolylmaleimide, a PKC inhibitor, inhibits TPA-induced PI-3 K. Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K activity.	Tetradecanoylphorbol Acetate	187-190	protein kinase C alpha	Homo sapiens	46-49
10625951-7	1999	Furthermore, we have investigated the role of PKC and its isozymes in the synergistic induction of PI-3 K by TPA and insulin and found that bisindolylmaleimide, a PKC inhibitor, inhibits TPA-induced PI-3 K. Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K activity.	Tetradecanoylphorbol Acetate	187-190	protein kinase C alpha	Homo sapiens	46-49
10455033-7	1999	Furthermore, sucrose-density-gradient centrifugation and immunofluorescence microscopy demonstrated that PKCalpha was translocated to the endoplasmic reticulum membrane in cells expressing GPI-PLD, in contrast with its association with the plasma membrane in cells treated with PMA.	Tetradecanoylphorbol Acetate	278-281	protein kinase C alpha	Homo sapiens	105-113
10464065-9	1999	The short-chain fatty acids, acetate, propionate, butyrate and valerate, the activator of protein kinase C (phorbol-12-myristate-13-acetate) and tumour necrosis factor-alpha (TNF-alpha) all stimulated the secretion of IL-8.	Tetradecanoylphorbol Acetate	108-139	C-X-C motif chemokine ligand 8	Homo sapiens	218-222
10615432-10	1999	In both cell types, the secretion of PAI-1 was stimulated by bFGF and PDGF, as well as by uPA and tPA.	Tetradecanoylphorbol Acetate	98-101	serpin family E member 1	Rattus norvegicus	37-42
10469622-0	1999	Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters.	Tetradecanoylphorbol Acetate	91-94	glutaredoxin	Mus musculus	52-64
10469622-1	1999	We have measured the levels of thioredoxin, thioredoxin reductase and glutaredoxin enzyme activity in mouse skin following topical application of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC) activator and tumor promoter.	Tetradecanoylphorbol Acetate	164-200	glutaredoxin	Mus musculus	70-82
10469622-3	1999	Multiple applications (twice per week for 2 weeks) of TPA increased glutaredoxin activity by &gt;300%.	Tetradecanoylphorbol Acetate	54-57	glutaredoxin	Mus musculus	68-80
10469622-7	1999	Multiple applications of TPA to tumor initiated (7,12-dimethyl[a]benzanthracene-treated) skin resulted in elevated levels of both the thioredoxin and glutaredoxin systems when examined 6 days after the last phorbol ester treatment.	Tetradecanoylphorbol Acetate	25-28	glutaredoxin	Mus musculus	150-162
10469622-8	1999	Induction of thioredoxin, thioredoxin reductase and glutaredoxin activities by TPA and calcium ionophores may play a general role in the epigenetic mechanism of tumor promotion via thiol redox control mechanisms.	Tetradecanoylphorbol Acetate	79-82	glutaredoxin	Mus musculus	52-64
10487706-7	1999	In benign cells, however, TPA induced a small, though significant, increase in TIMP-1.	Tetradecanoylphorbol Acetate	26-29	TIMP metallopeptidase inhibitor 1	Homo sapiens	79-85
10508275-2	1999	In this study we investigated the role of IRF-1 in phorbol 12-myristate 13-acetate (PMA)-induced monocyte/macrophage differentiation of human monoblastic U937 cells.	Tetradecanoylphorbol Acetate	51-82	interferon regulatory factor 1	Homo sapiens	42-47
10508275-2	1999	In this study we investigated the role of IRF-1 in phorbol 12-myristate 13-acetate (PMA)-induced monocyte/macrophage differentiation of human monoblastic U937 cells.	Tetradecanoylphorbol Acetate	84-87	interferon regulatory factor 1	Homo sapiens	42-47
10487706-8	1999	The MMP-1 stimulation by EGF and lack of TPA-induced rise in TIMP-1 in malignant cells, in sharp contrast to the effects obtained in benign thyrocytes, seems to indicate that the MMP: TIMP balance favors a more extensive extracellular matrix protein breakdown by malignant thyrocytes, as expected of cells exhibiting invasive capacity.	Tetradecanoylphorbol Acetate	41-44	TIMP metallopeptidase inhibitor 1	Homo sapiens	61-67
10487706-9	1999	TSH (10-500 microU/mL) failed to significantly influence basal MMP-1 or TIMP-1 mRNA levels, but it caused a dose-dependent inhibition in TPA- and EGF-induced MMP-1 mRNA in malignant cells, and TPA-stimulated MMP-1 and TIMP-1 in benign cells.	Tetradecanoylphorbol Acetate	137-140	TIMP metallopeptidase inhibitor 1	Homo sapiens	218-224
10496313-5	1999	In contrast, after in vitro stimulation of peripheral blood PMN with phorbol myristate acetate, CD66c was much less up-regulated compared with CD66a and CD66b.	Tetradecanoylphorbol Acetate	69-94	CEA cell adhesion molecule 8	Homo sapiens	153-158
10496313-6	1999	All samples of synovial fluid PMN exhibited an additional increase in the expression of CD66a, CD66b, and CD66c when stimulated with phorbol myristate acetate in vitro.	Tetradecanoylphorbol Acetate	133-158	CEA cell adhesion molecule 8	Homo sapiens	95-100
10454561-5	1999	In the present study, we demonstrate that expression of TD-IkappaBalpha blocked phorbol myristate acetate-phytohemagglutinin or tumor necrosis factor alpha-induced IkappaBalpha gene transcription and abolished NF-kappaB DNA binding activity, due to the continued cytoplasmic sequestration of RelA(p65) by TD-IkappaBalpha.	Tetradecanoylphorbol Acetate	80-105	NFKB inhibitor alpha	Homo sapiens	59-71
10536988-3	1999	TPA induces serine-phosphorylation of the 180 kDa-bullous pemphigoid antigen (BPAG2), generating 190 kDa-phosphorylated BPAG2, and dissociates BPAG2 from hemidesmosomes.	Tetradecanoylphorbol Acetate	0-3	collagen type XVII alpha 1 chain	Homo sapiens	78-83
10536988-3	1999	TPA induces serine-phosphorylation of the 180 kDa-bullous pemphigoid antigen (BPAG2), generating 190 kDa-phosphorylated BPAG2, and dissociates BPAG2 from hemidesmosomes.	Tetradecanoylphorbol Acetate	0-3	collagen type XVII alpha 1 chain	Homo sapiens	120-125
10536988-3	1999	TPA induces serine-phosphorylation of the 180 kDa-bullous pemphigoid antigen (BPAG2), generating 190 kDa-phosphorylated BPAG2, and dissociates BPAG2 from hemidesmosomes.	Tetradecanoylphorbol Acetate	0-3	collagen type XVII alpha 1 chain	Homo sapiens	120-125
10454561-5	1999	In the present study, we demonstrate that expression of TD-IkappaBalpha blocked phorbol myristate acetate-phytohemagglutinin or tumor necrosis factor alpha-induced IkappaBalpha gene transcription and abolished NF-kappaB DNA binding activity, due to the continued cytoplasmic sequestration of RelA(p65) by TD-IkappaBalpha.	Tetradecanoylphorbol Acetate	80-105	NFKB inhibitor alpha	Homo sapiens	164-176
10536988-4	1999	TPA-treatment also causes secretion of urokinase-type plasminogen activator (uPA) and expression of its receptor (uPAR), which activates plasminogen to plasmin and may digest extracellular domains of desmosomes and hemidesmosomes.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase	Homo sapiens	39-75
10536988-4	1999	TPA-treatment also causes secretion of urokinase-type plasminogen activator (uPA) and expression of its receptor (uPAR), which activates plasminogen to plasmin and may digest extracellular domains of desmosomes and hemidesmosomes.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase	Homo sapiens	77-80
10454561-5	1999	In the present study, we demonstrate that expression of TD-IkappaBalpha blocked phorbol myristate acetate-phytohemagglutinin or tumor necrosis factor alpha-induced IkappaBalpha gene transcription and abolished NF-kappaB DNA binding activity, due to the continued cytoplasmic sequestration of RelA(p65) by TD-IkappaBalpha.	Tetradecanoylphorbol Acetate	80-105	tumor necrosis factor	Homo sapiens	128-155
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	381-384	plasminogen activator, urokinase	Homo sapiens	435-438
10454570-0	1999	Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	202-231	plasminogen activator, urokinase	Homo sapiens	129-165
10454570-1	1999	We have investigated the in vivo and in vitro regulation of the human urokinase-type plasminogen activator (uPA) gene by interleukin-1 (IL-1) and analyzed the transcription factors and signalling pathways involved in the response of the -2.0-kb uPA enhancer to IL-1 induction and to tetradecanoyl phorbol acetate (TPA) induction.	Tetradecanoylphorbol Acetate	283-312	plasminogen activator, urokinase	Homo sapiens	108-111
10454570-1	1999	We have investigated the in vivo and in vitro regulation of the human urokinase-type plasminogen activator (uPA) gene by interleukin-1 (IL-1) and analyzed the transcription factors and signalling pathways involved in the response of the -2.0-kb uPA enhancer to IL-1 induction and to tetradecanoyl phorbol acetate (TPA) induction.	Tetradecanoylphorbol Acetate	314-317	plasminogen activator, urokinase	Homo sapiens	108-111
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	260-263	mitogen-activated protein kinase 3	Homo sapiens	295-332
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	260-263	mitogen-activated protein kinase 3	Homo sapiens	334-339
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	260-263	mitogen-activated protein kinase 1	Homo sapiens	345-350
10454561-5	1999	In the present study, we demonstrate that expression of TD-IkappaBalpha blocked phorbol myristate acetate-phytohemagglutinin or tumor necrosis factor alpha-induced IkappaBalpha gene transcription and abolished NF-kappaB DNA binding activity, due to the continued cytoplasmic sequestration of RelA(p65) by TD-IkappaBalpha.	Tetradecanoylphorbol Acetate	80-105	NFKB inhibitor alpha	Homo sapiens	164-176
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	260-263	plasminogen activator, urokinase	Homo sapiens	435-438
10471787-3	1999	Here we provide evidence that lyso-PC can phosphorylate cyclic AMP responsive element binding protein (CREB) and thereby activate the jun2 12-O-tetradecanoylphorbol 13-acetate response element (jun2TRE) site of the c-jun promoter, which appears to be the major molecular mechanism involved in lyso-PC-induced c-jun gene expression in cultured bovine aortic endothelial cells (BAEC).	Tetradecanoylphorbol Acetate	139-175	cAMP responsive element binding protein 1	Bos taurus	103-107
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	381-384	mitogen-activated protein kinase 3	Homo sapiens	295-332
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	381-384	mitogen-activated protein kinase 3	Homo sapiens	334-339
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	381-384	mitogen-activated protein kinase 1	Homo sapiens	345-350
10487519-4	1999	However, induction of K6-driven tTA expression by the tumor promoter (12-O-tetradecanoylphorbol-13-acetate) (TPA) led to very high levels of epidermal ODC activity and robust hyperplasia, especially involving hair follicles.	Tetradecanoylphorbol Acetate	70-106	keratin 6	Mus musculus	22-24
10487519-4	1999	However, induction of K6-driven tTA expression by the tumor promoter (12-O-tetradecanoylphorbol-13-acetate) (TPA) led to very high levels of epidermal ODC activity and robust hyperplasia, especially involving hair follicles.	Tetradecanoylphorbol Acetate	109-112	keratin 6	Mus musculus	22-24
10494772-4	1999	A stronger positive association between fibrinogen or tissue-type plasminogen activator antigen (tPA-ag) and fasting insulin is observed in women than in men.	Tetradecanoylphorbol Acetate	97-100	insulin	Homo sapiens	117-124
10494772-13	1999	For tPA-ag these associations were for insulin beta = 0.76 mg/U (0.54, 0.98) and beta = 0.89 mg/U (0.67, 1.11), and for HOMA-IR beta = 0.47 microg/microU mol/l (0.33, 0.61) and beta = 0.45 microg/microU mol/l (0.33, 0.57), women and men respectively.	Tetradecanoylphorbol Acetate	4-7	insulin	Homo sapiens	39-46
10494772-14	1999	The associations of fibrinogen and tPA-ag with insulin and HOMA-IR were sharply reduced in male smokers compared to male non-smokers, however the strength of the associations in male non-smokers did not reach that in women.	Tetradecanoylphorbol Acetate	35-38	insulin	Homo sapiens	47-54
10494772-15	1999	Fibrinogen and tPA-ag are independently related with markers of insulin resistance, with the relation with fibrinogen being stronger in women than in men.	Tetradecanoylphorbol Acetate	15-18	insulin	Homo sapiens	64-71
10494772-15	1999	Fibrinogen and tPA-ag are independently related with markers of insulin resistance, with the relation with fibrinogen being stronger in women than in men.	Tetradecanoylphorbol Acetate	15-18	fibrinogen beta chain	Homo sapiens	107-117
10446131-8	1999	ATII induced extracellular-signal regulated kinase (p42/44 ERK) activity as did phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	80-111	angiotensinogen	Homo sapiens	0-4
10446156-8	1999	Inhibition of MEK blocked both bombesin- and phorbol 12-myristate 13-acetate-induced secretion.	Tetradecanoylphorbol Acetate	45-76	mitogen-activated protein kinase kinase 7	Homo sapiens	14-17
10444401-10	1999	Protein kinase C downregulation by phorbol 12-myristate 13-acetate and/or inhibitors to protein kinase C, p60(src) kinase, and MAPK kinase inhibited BK-induced MAPK tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	35-66	kininogen 1	Homo sapiens	149-151
10448106-1	1999	Phorbol 12-myristate 13-acetate (PMA)-induced HIV-1 production in U1 cells was markedly suppressed by inhibitors of poly (ADP-ribose) polymerase (PARP).	Tetradecanoylphorbol Acetate	0-31	poly(ADP-ribose) polymerase 1	Homo sapiens	146-150
10448106-1	1999	Phorbol 12-myristate 13-acetate (PMA)-induced HIV-1 production in U1 cells was markedly suppressed by inhibitors of poly (ADP-ribose) polymerase (PARP).	Tetradecanoylphorbol Acetate	33-36	poly(ADP-ribose) polymerase 1	Homo sapiens	146-150
10448106-6	1999	NF-kappaB, which is known to mediate the PMA-induced activation of HIV-1 in U1 cells, was found to be activated approximately 5-fold in PMA-treated U1 cells.	Tetradecanoylphorbol Acetate	41-44	nuclear factor kappa B subunit 1	Homo sapiens	0-9
10448106-6	1999	NF-kappaB, which is known to mediate the PMA-induced activation of HIV-1 in U1 cells, was found to be activated approximately 5-fold in PMA-treated U1 cells.	Tetradecanoylphorbol Acetate	136-139	nuclear factor kappa B subunit 1	Homo sapiens	0-9
10446213-15	1999	In contrast, LPL Ser(5) phosphorylation and PMN adhesion induced by formylmethionyl-leucylphenylalanine or phorbol myristate acetate were not affected by PKA inhibitors, suggesting that a different kinase(s) is responsible for LPL phosphorylation in response to these agonists.	Tetradecanoylphorbol Acetate	107-132	lymphocyte cytosolic protein 1	Homo sapiens	13-16
10424764-6	1999	Further, the PKC selective inhibitor Go6976 potentiated VPA-induced cytotoxicity and TNF-alpha-induced cytotoxicity, whereas the PKC activator phorbol-12-myristate-13-acetate provided a significant protection against the cytotoxicity associated with VPA or TNF-alpha.	Tetradecanoylphorbol Acetate	143-174	tumor necrosis factor	Homo sapiens	257-266
10446065-4	1999	When treated with IL-6, macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells showed significantly reduced uptake and/or binding of the MSR ligand, acetylated LDL.	Tetradecanoylphorbol Acetate	74-105	interleukin 6	Homo sapiens	18-22
10446065-4	1999	When treated with IL-6, macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells showed significantly reduced uptake and/or binding of the MSR ligand, acetylated LDL.	Tetradecanoylphorbol Acetate	74-105	GLI family zinc finger 2	Homo sapiens	127-132
10446065-4	1999	When treated with IL-6, macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells showed significantly reduced uptake and/or binding of the MSR ligand, acetylated LDL.	Tetradecanoylphorbol Acetate	107-110	interleukin 6	Homo sapiens	18-22
10446065-4	1999	When treated with IL-6, macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells showed significantly reduced uptake and/or binding of the MSR ligand, acetylated LDL.	Tetradecanoylphorbol Acetate	107-110	GLI family zinc finger 2	Homo sapiens	127-132
10402232-7	1999	We recently demonstrated that the ability of substance P (SP) neuropeptide to activate MAP kinase pathway in U-373MG astrocytoma cells correlates with its ability to selectively translocate PKCepsilon from cytosolic to membrane fraction, and that PKC inhibitors (e.g. CGP 41251) inhibit the activation of this pathway by SP or the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	345-382	tachykinin precursor 1	Homo sapiens	45-56
10468798-5	1999	SDZ ASM 981 inhibits the phorbol myristate acetate/phytohaemagglutinin-stimulated transcription of a reporter gene coupled to the human IL-2 promoter in the human T-cell line Jurkat and the IgE/antigen-mediated transcription of a reporter gene coupled to the human tumour necrosis factor (TNF)-alpha promoter in the murine mast-cell line CPII.	Tetradecanoylphorbol Acetate	25-50	interleukin 2	Homo sapiens	136-140
10468798-5	1999	SDZ ASM 981 inhibits the phorbol myristate acetate/phytohaemagglutinin-stimulated transcription of a reporter gene coupled to the human IL-2 promoter in the human T-cell line Jurkat and the IgE/antigen-mediated transcription of a reporter gene coupled to the human tumour necrosis factor (TNF)-alpha promoter in the murine mast-cell line CPII.	Tetradecanoylphorbol Acetate	25-50	immunoglobulin heavy constant epsilon	Homo sapiens	190-193
10468798-5	1999	SDZ ASM 981 inhibits the phorbol myristate acetate/phytohaemagglutinin-stimulated transcription of a reporter gene coupled to the human IL-2 promoter in the human T-cell line Jurkat and the IgE/antigen-mediated transcription of a reporter gene coupled to the human tumour necrosis factor (TNF)-alpha promoter in the murine mast-cell line CPII.	Tetradecanoylphorbol Acetate	25-50	tumor necrosis factor	Homo sapiens	265-299
10455321-13	1999	Glaucine augmented cyclic AMP levels in human polymorphonuclear leukocytes challenged with N-formyl-Met-Leu-Phe (FMLP) or isoprenaline, and inhibited FMLP-induced superoxide generation, elastase release, leukotriene B4 production, [Ca2+]i signal and platelet aggregation as well as opsonized zymosan-, phorbol myristate acetate-, and A23187-induced superoxide release.	Tetradecanoylphorbol Acetate	302-327	formyl peptide receptor 1	Homo sapiens	150-154
10482923-3	1999	Here, we have investigated the particular protein kinase C (PKC) isoform(s) responsible for the inhibition of P2Y1 and P2Y2 receptor-evoked inositol phosphate (IP) formation by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	177-208	purinergic receptor P2Y2	Bos taurus	119-123
10413608-8	1999	Latrunculin A (1 microM) completely blocked PMA-induced increases in cytoskeletal alpha-actinin but reduced cytoskeletal recruitment of PKCbetaII only by 16%.	Tetradecanoylphorbol Acetate	44-47	actinin alpha 1	Homo sapiens	82-95
10543370-5	1999	Activation of protein kinase C by phorbol 12-myristate 13-acetate produced an almost complete inhibition of p53-independent apoptosis following irradiation, whereas no significant effect was observed on the rate of p53-induced apoptosis.	Tetradecanoylphorbol Acetate	34-65	tumor protein p53	Homo sapiens	108-111
10543370-6	1999	Although phorbol 12-myristate 13-acetate strongly induced p21 and stabilised p53 in the resting transfected Jurkat cells, neither apoptosis nor cell arrest was observed.	Tetradecanoylphorbol Acetate	9-40	tumor protein p53	Homo sapiens	77-80
10441128-4	1999	For the first time, we have now identified multiple basal phophopeptides and multiple phorbol myristate acetate (PMA) induced phosphopeptides of endogenous PLD1 in 3Y1 cells as well as of transiently expressed PLD1 in COS-7 cells.	Tetradecanoylphorbol Acetate	86-111	phospholipase D1	Rattus norvegicus	156-160
10441128-4	1999	For the first time, we have now identified multiple basal phophopeptides and multiple phorbol myristate acetate (PMA) induced phosphopeptides of endogenous PLD1 in 3Y1 cells as well as of transiently expressed PLD1 in COS-7 cells.	Tetradecanoylphorbol Acetate	113-116	phospholipase D1	Rattus norvegicus	156-160
10441128-4	1999	For the first time, we have now identified multiple basal phophopeptides and multiple phorbol myristate acetate (PMA) induced phosphopeptides of endogenous PLD1 in 3Y1 cells as well as of transiently expressed PLD1 in COS-7 cells.	Tetradecanoylphorbol Acetate	113-116	phospholipase D1	Rattus norvegicus	210-214
10402232-7	1999	We recently demonstrated that the ability of substance P (SP) neuropeptide to activate MAP kinase pathway in U-373MG astrocytoma cells correlates with its ability to selectively translocate PKCepsilon from cytosolic to membrane fraction, and that PKC inhibitors (e.g. CGP 41251) inhibit the activation of this pathway by SP or the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	345-382	tachykinin precursor 1	Homo sapiens	58-60
10402232-7	1999	We recently demonstrated that the ability of substance P (SP) neuropeptide to activate MAP kinase pathway in U-373MG astrocytoma cells correlates with its ability to selectively translocate PKCepsilon from cytosolic to membrane fraction, and that PKC inhibitors (e.g. CGP 41251) inhibit the activation of this pathway by SP or the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	384-387	tachykinin precursor 1	Homo sapiens	45-56
10402232-7	1999	We recently demonstrated that the ability of substance P (SP) neuropeptide to activate MAP kinase pathway in U-373MG astrocytoma cells correlates with its ability to selectively translocate PKCepsilon from cytosolic to membrane fraction, and that PKC inhibitors (e.g. CGP 41251) inhibit the activation of this pathway by SP or the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	384-387	tachykinin precursor 1	Homo sapiens	58-60
10497883-7	1999	The presence of phorbol 12-myristate 13-acetate (PMA; 10(-6) M) or estrogen (10(-8) M) caused a significant increase in regucalcin mRNA levels in the hepatoma cells cultured in serum-free medium, while insulin (5 x 10(-9) M) or dexamethasone (10(-6) M) had no effect.	Tetradecanoylphorbol Acetate	16-47	regucalcin	Rattus norvegicus	120-130
10497883-7	1999	The presence of phorbol 12-myristate 13-acetate (PMA; 10(-6) M) or estrogen (10(-8) M) caused a significant increase in regucalcin mRNA levels in the hepatoma cells cultured in serum-free medium, while insulin (5 x 10(-9) M) or dexamethasone (10(-6) M) had no effect.	Tetradecanoylphorbol Acetate	49-52	regucalcin	Rattus norvegicus	120-130
10497883-8	1999	Bay K 8644-stimulated regucalcin mRNA expression in the hepatoma cells was completely blocked in the presence of trifluoperazine (10(-5) M), an antagonist of calmodulin, or staurosporine (10(-7) M), an inhibitor of protein kinase C. The stimulatory effect of PMA was clearly inhibited in the presence of stauroporine.	Tetradecanoylphorbol Acetate	259-262	regucalcin	Rattus norvegicus	22-32
10399964-4	1999	Pericellular deposition of EDA-containing fibronectin (EDA+FN) was essential for TPA-induced cohort migration.	Tetradecanoylphorbol Acetate	81-84	fibronectin 1	Homo sapiens	42-53
10397715-7	1999	After cotransfection with human wild-type c-mpl, the cells (UT-7/EPO-MPL) responded to phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) with enhanced PAI-1 mRNA expression within 24 to 48 hours.	Tetradecanoylphorbol Acetate	87-118	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	42-47
10452523-2	1999	The C1a and C1b domains play equivalent roles for translocation in response to phorbol 12-myristate 13-acetate, mezerein, and (-)octylindolactam V. These results contrast with those previously reported for PKC delta, suggesting that the domains play different roles in different PKC isoforms.	Tetradecanoylphorbol Acetate	79-110	protein kinase C, alpha	Mus musculus	206-209
10397721-4	1999	PTP-RO mRNA and protein expression are upregulated upon phorbol 12-myristate 13-acetate (PMA) treatment of the megakaryocytic cell lines CMS, CMK, and Dami.	Tetradecanoylphorbol Acetate	56-87	C-X-C motif chemokine ligand 9	Homo sapiens	142-145
10397721-4	1999	PTP-RO mRNA and protein expression are upregulated upon phorbol 12-myristate 13-acetate (PMA) treatment of the megakaryocytic cell lines CMS, CMK, and Dami.	Tetradecanoylphorbol Acetate	89-92	C-X-C motif chemokine ligand 9	Homo sapiens	142-145
10397715-7	1999	After cotransfection with human wild-type c-mpl, the cells (UT-7/EPO-MPL) responded to phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) with enhanced PAI-1 mRNA expression within 24 to 48 hours.	Tetradecanoylphorbol Acetate	87-118	erythropoietin	Homo sapiens	65-68
10397715-7	1999	After cotransfection with human wild-type c-mpl, the cells (UT-7/EPO-MPL) responded to phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) with enhanced PAI-1 mRNA expression within 24 to 48 hours.	Tetradecanoylphorbol Acetate	87-118	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	69-72
10423169-3	1999	In mouse 3T3 cells, enhanced phosphorylation of ERK2 was detected only within the first hour of treatment with TPA but not with OA.	Tetradecanoylphorbol Acetate	111-114	mitogen-activated protein kinase 1	Mus musculus	48-52
10423169-4	1999	The early response to both TPA and OA, in turn, was lost in another established cell line, the PNT2 prostate epithelial cells, where we could detect increased levels of phosphorylated ERK2 only after a 24-hr treatment with OA.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Homo sapiens	184-188
10423169-7	1999	We conclude that the effects of OA and TPA on the phosphorylation states of ERK2 could be related to the cell type, and that the operational equivalence between these two different tumor promoters is maximal in normal cells.	Tetradecanoylphorbol Acetate	39-42	mitogen-activated protein kinase 1	Homo sapiens	76-80
10393966-4	1999	As defined by IL-2 generation, activation of T cells stimulated with classical mitogens [phorbol 12-myristate 13-acetate (PMA) + anti-CD3, PMA + phytohemagglutinin, and PMA + ionomycin] is unaffected by the expression of Nef.	Tetradecanoylphorbol Acetate	89-120	interleukin 2	Homo sapiens	14-18
10391937-6	1999	A protein kinase C (PKC) inhibitor diminished zymosan-induced AA liberation, while a PKC activator, phorbol 12-myristate 13-acetate (PMA), enhanced the liberation.	Tetradecanoylphorbol Acetate	133-136	protein kinase C, alpha	Mus musculus	85-88
10388538-8	1999	These results suggest that the inhibition of PMA-induced HA adhesion by IFN-gamma and IL-4 may influence B cell migration through their ability to downregulate CD44-HA interactions.	Tetradecanoylphorbol Acetate	45-48	interferon gamma	Homo sapiens	72-81
10388538-8	1999	These results suggest that the inhibition of PMA-induced HA adhesion by IFN-gamma and IL-4 may influence B cell migration through their ability to downregulate CD44-HA interactions.	Tetradecanoylphorbol Acetate	45-48	interleukin 4	Homo sapiens	86-90
10391937-6	1999	A protein kinase C (PKC) inhibitor diminished zymosan-induced AA liberation, while a PKC activator, phorbol 12-myristate 13-acetate (PMA), enhanced the liberation.	Tetradecanoylphorbol Acetate	100-131	protein kinase C, alpha	Mus musculus	85-88
10403525-4	1999	Unexpectedly, pretreatment of cells with ara-C or dFdC opposed BRY- and PMA-related induction of the cyclin-dependent kinase inhibitors (CDKIs) p21CIP1 and/or p27KIP1.	Tetradecanoylphorbol Acetate	72-75	cyclin dependent kinase inhibitor 1A	Homo sapiens	144-151
10398310-9	1999	Co-expression of CD7 on CD34+ cells was induced to decrease significantly after short-term in vitro culture with the differentiation-inducing agent phorbol ester (PMA) and with a combination of cytokines (stem-cell factor, interleukin-3 and granulocyte colony-stimulating factor).	Tetradecanoylphorbol Acetate	163-166	CD34 molecule	Homo sapiens	24-28
10413111-1	1999	ET-18-OCH3, but not ELL-12, blunted the increase in membrane protein kinase C (PKC) activity induced by 12-O-tetradecanoylphorbol 13-myristate (TPA) and markedly reduced levels of PKC alpha in NIH 3T3 fibroblasts.	Tetradecanoylphorbol Acetate	144-147	protein kinase C alpha	Homo sapiens	79-82
10397677-6	1999	The inhibition of PKC by chelerythrine or its downregulation by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis and blocked the phosphorylation of MAPK and c-myc expression in response to bFGF.	Tetradecanoylphorbol Acetate	64-95	proline rich transmembrane protein 2	Homo sapiens	18-21
10397677-6	1999	The inhibition of PKC by chelerythrine or its downregulation by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis and blocked the phosphorylation of MAPK and c-myc expression in response to bFGF.	Tetradecanoylphorbol Acetate	64-95	fibroblast growth factor 2	Homo sapiens	112-116
10397677-6	1999	The inhibition of PKC by chelerythrine or its downregulation by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis and blocked the phosphorylation of MAPK and c-myc expression in response to bFGF.	Tetradecanoylphorbol Acetate	64-95	mitogen-activated protein kinase 1	Homo sapiens	174-178
10397677-6	1999	The inhibition of PKC by chelerythrine or its downregulation by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis and blocked the phosphorylation of MAPK and c-myc expression in response to bFGF.	Tetradecanoylphorbol Acetate	64-95	fibroblast growth factor 2	Homo sapiens	215-219
10397677-6	1999	The inhibition of PKC by chelerythrine or its downregulation by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis and blocked the phosphorylation of MAPK and c-myc expression in response to bFGF.	Tetradecanoylphorbol Acetate	97-100	proline rich transmembrane protein 2	Homo sapiens	18-21
10397677-6	1999	The inhibition of PKC by chelerythrine or its downregulation by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis and blocked the phosphorylation of MAPK and c-myc expression in response to bFGF.	Tetradecanoylphorbol Acetate	97-100	fibroblast growth factor 2	Homo sapiens	112-116
10397677-6	1999	The inhibition of PKC by chelerythrine or its downregulation by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis and blocked the phosphorylation of MAPK and c-myc expression in response to bFGF.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 1	Homo sapiens	174-178
10397677-6	1999	The inhibition of PKC by chelerythrine or its downregulation by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis and blocked the phosphorylation of MAPK and c-myc expression in response to bFGF.	Tetradecanoylphorbol Acetate	97-100	fibroblast growth factor 2	Homo sapiens	215-219
10406952-6	1999	IL-6RDeltaIg was shed as effectively as wild-type IL-6R from transfected COS-7 cells upon 4beta-phorbol 12-myristate 13-acetate (PMA) treatment, whereas nonstimulated shedding of IL-6RDeltaIg was not observed.	Tetradecanoylphorbol Acetate	90-127	interleukin 6 receptor	Homo sapiens	0-5
10501019-2	1999	The PKC activators, phorbol 12-myristate 13-acetate (PMA) or phorbol 12,13-dibutyrate (PDBu), significantly decreased [3H]choline cotransport.	Tetradecanoylphorbol Acetate	20-51	proline rich transmembrane protein 2	Homo sapiens	4-7
10501019-2	1999	The PKC activators, phorbol 12-myristate 13-acetate (PMA) or phorbol 12,13-dibutyrate (PDBu), significantly decreased [3H]choline cotransport.	Tetradecanoylphorbol Acetate	53-56	proline rich transmembrane protein 2	Homo sapiens	4-7
10391868-6	1999	Similarly, LTB4 liberation was significantly reduced in response to fMLP and phorbol myristate acetate in unprimed and TNF-alpha-primed pregnancy PMNs.	Tetradecanoylphorbol Acetate	77-102	tumor necrosis factor	Homo sapiens	119-128
10419652-3	1999	The optimal time for positive identification of IL-2 in both blood and BAL was 5 h after PMA/ionomycin stimulation, whereas the first peak for IFN-gamma was found after 5 h in blood but after only 3 h in BAL.	Tetradecanoylphorbol Acetate	89-92	interleukin 2	Homo sapiens	48-52
10406952-6	1999	IL-6RDeltaIg was shed as effectively as wild-type IL-6R from transfected COS-7 cells upon 4beta-phorbol 12-myristate 13-acetate (PMA) treatment, whereas nonstimulated shedding of IL-6RDeltaIg was not observed.	Tetradecanoylphorbol Acetate	129-132	interleukin 6 receptor	Homo sapiens	0-5
10400418-5	1999	In comparison, the stimulation of Raf-1 by phorbol ester (TPA) activates the MAPK pathway, causes MAPK-dependent p21WAF1/CIP1 induction, Rb dephosphorylation and growth arrest without Bcl-2 phosphorylation or apoptosis.	Tetradecanoylphorbol Acetate	58-61	cyclin dependent kinase inhibitor 1A	Homo sapiens	121-125
10400418-5	1999	In comparison, the stimulation of Raf-1 by phorbol ester (TPA) activates the MAPK pathway, causes MAPK-dependent p21WAF1/CIP1 induction, Rb dephosphorylation and growth arrest without Bcl-2 phosphorylation or apoptosis.	Tetradecanoylphorbol Acetate	58-61	BCL2 apoptosis regulator	Homo sapiens	184-189
10400418-6	1999	Like TPA, cAMP induces p21WAF1/CIP1 but does not cause Bcl-2 phosphorylation.	Tetradecanoylphorbol Acetate	5-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	23-35
10373471-3	1999	We investigated in intact (human adenocarcinoma A549 cells) the role of RhoA and ARF in activation of PLD by phorbol 12-myristate 13-acetate, bradykinin, and/or sphingosine 1-phosphate.	Tetradecanoylphorbol Acetate	109-140	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	102-105
10406459-0	1999	A dominant role for the Raf-MEK pathway in forskolin, 12-O-tetradecanoyl-phorbol acetate, and platelet-derived growth factor-induced CREB (cAMP-responsive element-binding protein) activation, uncoupled from serine 133 phosphorylation in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	54-88	zinc fingers and homeoboxes 2	Mus musculus	24-27
10406459-0	1999	A dominant role for the Raf-MEK pathway in forskolin, 12-O-tetradecanoyl-phorbol acetate, and platelet-derived growth factor-induced CREB (cAMP-responsive element-binding protein) activation, uncoupled from serine 133 phosphorylation in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	54-88	cAMP responsive element binding protein 1	Mus musculus	133-137
10406459-1	1999	In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	70-104	cAMP responsive element binding protein 1	Mus musculus	134-138
10406459-1	1999	In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	70-104	cAMP responsive element binding protein 1	Mus musculus	140-179
10406459-1	1999	In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	106-109	cAMP responsive element binding protein 1	Mus musculus	134-138
10406459-1	1999	In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	106-109	cAMP responsive element binding protein 1	Mus musculus	140-179
10406459-2	1999	While forskolin was the most potent activator of CREB, TPA or PDGF modestly increased CREB activity.	Tetradecanoylphorbol Acetate	55-58	cAMP responsive element binding protein 1	Mus musculus	86-90
10395330-3	1999	TNF-alpha(-/-) mice were resistant to development of benign and malignant skin tumors, whether induced by initiation with DMBA and promotion with TPA or by repeated dosing with DMBA.	Tetradecanoylphorbol Acetate	146-149	tumor necrosis factor	Mus musculus	0-9
10395330-8	1999	TNF-alpha was extensively induced in the epidermis, but not the dermis, in TPA-treated wild-type skin, indicating that dermal inflammation is controlled by keratinocyte TNF-alpha production.	Tetradecanoylphorbol Acetate	75-78	tumor necrosis factor	Mus musculus	0-9
10395330-8	1999	TNF-alpha was extensively induced in the epidermis, but not the dermis, in TPA-treated wild-type skin, indicating that dermal inflammation is controlled by keratinocyte TNF-alpha production.	Tetradecanoylphorbol Acetate	75-78	tumor necrosis factor	Mus musculus	169-178
10373471-5	1999	Expression of C3 toxin or Rho19N increased basal and decreased phorbol 12-myristate 13-acetate-stimulated PLD activity.	Tetradecanoylphorbol Acetate	63-94	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	106-109
10373477-3	1999	Although treatment with the phorbol myristate acetate resulted in ERK activation and complete dissociation of the Grb2-SOS complex, there was no effect on subsequent insulin-stimulated Ras activation.	Tetradecanoylphorbol Acetate	28-53	mitogen-activated protein kinase 1	Homo sapiens	66-69
10373501-8	1999	12-O-Tetradecanoylphorbol-13-acetate- and interleukin-1-induced transactivation by NF-kappaB, however, was lower in IkappaBbeta1-overexpressing cells.	Tetradecanoylphorbol Acetate	0-36	nuclear factor kappa B subunit 1	Homo sapiens	83-92
10373477-3	1999	Although treatment with the phorbol myristate acetate resulted in ERK activation and complete dissociation of the Grb2-SOS complex, there was no effect on subsequent insulin-stimulated Ras activation.	Tetradecanoylphorbol Acetate	28-53	growth factor receptor bound protein 2	Homo sapiens	114-118
10373477-3	1999	Although treatment with the phorbol myristate acetate resulted in ERK activation and complete dissociation of the Grb2-SOS complex, there was no effect on subsequent insulin-stimulated Ras activation.	Tetradecanoylphorbol Acetate	28-53	xylosyltransferase 2	Homo sapiens	119-122
10364257-4	1999	Experiments using this method reveal that stimulation of human neutrophils with the Gi-coupled receptor agonists N-formyl-methionyl-leucyl-phenylalanine (fMLP) and leukotriene B4 (LTB4) leads to a rapid and transient increase in the GTP-bound state of Rac2, whereas phorbol myristate acetate (PMA) causes a slow but more sustained activation of Rac2.	Tetradecanoylphorbol Acetate	266-291	formyl peptide receptor 1	Homo sapiens	154-158
10364257-4	1999	Experiments using this method reveal that stimulation of human neutrophils with the Gi-coupled receptor agonists N-formyl-methionyl-leucyl-phenylalanine (fMLP) and leukotriene B4 (LTB4) leads to a rapid and transient increase in the GTP-bound state of Rac2, whereas phorbol myristate acetate (PMA) causes a slow but more sustained activation of Rac2.	Tetradecanoylphorbol Acetate	293-296	formyl peptide receptor 1	Homo sapiens	154-158
10364470-3	1999	An-I, An-Ia, and TB-III suppressed the superoxide generations induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner, but enhanced that induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	212-243	formyl peptide receptor 1	Homo sapiens	114-118
10364470-3	1999	An-I, An-Ia, and TB-III suppressed the superoxide generations induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner, but enhanced that induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	245-248	formyl peptide receptor 1	Homo sapiens	114-118
10422648-3	1999	In a culture of human neutrophils, phorbol myristate acetate (PMA) and calcium ionophore increased elastase activity in the supernatants, which was amplified by co-existing mononuclear leukocytes.	Tetradecanoylphorbol Acetate	35-60	elastase, neutrophil expressed	Rattus norvegicus	99-107
10422648-3	1999	In a culture of human neutrophils, phorbol myristate acetate (PMA) and calcium ionophore increased elastase activity in the supernatants, which was amplified by co-existing mononuclear leukocytes.	Tetradecanoylphorbol Acetate	62-65	elastase, neutrophil expressed	Rattus norvegicus	99-107
10362531-1	1999	Activation of the neutrophil NADPH oxidase by either the bacterial peptide fMLP or phorbol myristate acetate (PMA) is partially suppressed by SB 203580, a specific inhibitor of the MAP kinase family member, SAPK2/p38.	Tetradecanoylphorbol Acetate	83-108	mitogen-activated protein kinase 14	Homo sapiens	213-216
10362531-1	1999	Activation of the neutrophil NADPH oxidase by either the bacterial peptide fMLP or phorbol myristate acetate (PMA) is partially suppressed by SB 203580, a specific inhibitor of the MAP kinase family member, SAPK2/p38.	Tetradecanoylphorbol Acetate	110-113	mitogen-activated protein kinase 14	Homo sapiens	213-216
10421056-5	1999	In melanocytes cultured without phorbol 12-myristate 13-acetate (PMA) the neurofibromin half-lives were 24 h (healthy controls, MC), 26 h (apparently healthy skin of NF1 patients, MNFS) and 25 h (cafe-au-lait macules of NF1 patients, MNFC).	Tetradecanoylphorbol Acetate	65-68	neurofibromin 1	Homo sapiens	74-87
10366574-5	1999	Meanwhile, constitutive expression of iNOS mRNA was inhibited by TPA.	Tetradecanoylphorbol Acetate	65-68	nitric oxide synthase 2	Homo sapiens	38-42
14634280-2	1999	Furthermore, the NF-kappa B/Rel inducer, phorbol-12-myristate-13-acetate (PMA), has been reported to suppress the CD95-induced apoptosis of human T lymphocytes.	Tetradecanoylphorbol Acetate	41-72	nuclear factor kappa B subunit 1	Homo sapiens	17-27
10392899-0	1999	The Wilms" tumor suppressor, WT1, inhibits 12-O-tetradecanoylphorbol-13-acetate activation of the multidrug resistance-1 promoter.	Tetradecanoylphorbol Acetate	43-79	WT1 transcription factor	Homo sapiens	29-32
14634280-2	1999	Furthermore, the NF-kappa B/Rel inducer, phorbol-12-myristate-13-acetate (PMA), has been reported to suppress the CD95-induced apoptosis of human T lymphocytes.	Tetradecanoylphorbol Acetate	74-77	nuclear factor kappa B subunit 1	Homo sapiens	17-27
10339499-5	1999	Our results show that TPA + IFN-gamma treatment led to an inhibition of v-Myc- and c-Myc-dependent transcription, and a specific reduction of v-Myc:Max complexes and associated DNA-binding activity, whereas the steady state level of the v-Myc protein was only marginally affected.	Tetradecanoylphorbol Acetate	22-25	interferon gamma	Homo sapiens	28-37
10339499-8	1999	Phosphatase treatment of Myc:Max complexes lead to their dissociation, thus mimicking the effect of TPA + IFN-gamma.	Tetradecanoylphorbol Acetate	100-103	interferon gamma	Homo sapiens	106-115
10357779-5	1999	Application of DMEP protected against the losses provoked in levels of glutathione and activity of catalase and superoxide dismutase in skin and liver of animals by the application of DMBA/TPA.	Tetradecanoylphorbol Acetate	189-192	catalase	Mus musculus	99-107
10357776-4	1999	Butyrate-induced expression of carcinoembryonic antigen and interleukin-8, dome formation and cell turnover were also markedly augmented by pre-treatment with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	159-184	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
10392899-0	1999	The Wilms" tumor suppressor, WT1, inhibits 12-O-tetradecanoylphorbol-13-acetate activation of the multidrug resistance-1 promoter.	Tetradecanoylphorbol Acetate	43-79	ATP binding cassette subfamily B member 1	Homo sapiens	98-120
10392899-3	1999	We have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases transcription of the MDR1 gene and activates the MDR1 promoter, and that promoter activation by TPA requires binding of the zinc finger transcription factor EGR1 to specific MDR1 promoter sequences (C. McCoy and M. M. Cornwell, Mol.	Tetradecanoylphorbol Acetate	26-62	ATP binding cassette subfamily B member 1	Homo sapiens	100-104
10400316-5	1999	C2-ceramide inhibited the IL-6 synthesis induced by PGF2alpha or 12-O-tetradecanoylphorbol-13-acetate, an activator of PKC.	Tetradecanoylphorbol Acetate	65-101	interleukin 6	Mus musculus	26-30
10392899-3	1999	We have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases transcription of the MDR1 gene and activates the MDR1 promoter, and that promoter activation by TPA requires binding of the zinc finger transcription factor EGR1 to specific MDR1 promoter sequences (C. McCoy and M. M. Cornwell, Mol.	Tetradecanoylphorbol Acetate	26-62	ATP binding cassette subfamily B member 1	Homo sapiens	128-132
10392899-3	1999	We have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases transcription of the MDR1 gene and activates the MDR1 promoter, and that promoter activation by TPA requires binding of the zinc finger transcription factor EGR1 to specific MDR1 promoter sequences (C. McCoy and M. M. Cornwell, Mol.	Tetradecanoylphorbol Acetate	26-62	ATP binding cassette subfamily B member 1	Homo sapiens	128-132
10392899-3	1999	We have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases transcription of the MDR1 gene and activates the MDR1 promoter, and that promoter activation by TPA requires binding of the zinc finger transcription factor EGR1 to specific MDR1 promoter sequences (C. McCoy and M. M. Cornwell, Mol.	Tetradecanoylphorbol Acetate	64-67	ATP binding cassette subfamily B member 1	Homo sapiens	100-104
10392899-3	1999	We have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases transcription of the MDR1 gene and activates the MDR1 promoter, and that promoter activation by TPA requires binding of the zinc finger transcription factor EGR1 to specific MDR1 promoter sequences (C. McCoy and M. M. Cornwell, Mol.	Tetradecanoylphorbol Acetate	64-67	ATP binding cassette subfamily B member 1	Homo sapiens	128-132
10392899-3	1999	We have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases transcription of the MDR1 gene and activates the MDR1 promoter, and that promoter activation by TPA requires binding of the zinc finger transcription factor EGR1 to specific MDR1 promoter sequences (C. McCoy and M. M. Cornwell, Mol.	Tetradecanoylphorbol Acetate	64-67	ATP binding cassette subfamily B member 1	Homo sapiens	128-132
10392899-3	1999	We have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases transcription of the MDR1 gene and activates the MDR1 promoter, and that promoter activation by TPA requires binding of the zinc finger transcription factor EGR1 to specific MDR1 promoter sequences (C. McCoy and M. M. Cornwell, Mol.	Tetradecanoylphorbol Acetate	175-178	ATP binding cassette subfamily B member 1	Homo sapiens	100-104
10392899-3	1999	We have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases transcription of the MDR1 gene and activates the MDR1 promoter, and that promoter activation by TPA requires binding of the zinc finger transcription factor EGR1 to specific MDR1 promoter sequences (C. McCoy and M. M. Cornwell, Mol.	Tetradecanoylphorbol Acetate	175-178	ATP binding cassette subfamily B member 1	Homo sapiens	128-132
10545022-8	1999	Only a combination of depletion of PKC by prolonged stimulation with a high concentration of phorbol 12,13 dibutyrate (PDBu) and treatment with antisense ODNs effectively inhibited L-10 cell invasion even in the presence of TPA.	Tetradecanoylphorbol Acetate	224-227	protein kinase C alpha	Homo sapiens	35-38
10392899-3	1999	We have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases transcription of the MDR1 gene and activates the MDR1 promoter, and that promoter activation by TPA requires binding of the zinc finger transcription factor EGR1 to specific MDR1 promoter sequences (C. McCoy and M. M. Cornwell, Mol.	Tetradecanoylphorbol Acetate	175-178	ATP binding cassette subfamily B member 1	Homo sapiens	128-132
10392899-6	1999	We demonstrate here that the Wilms" tumor (WT) suppressor, WT1, a member of the EGR family, inhibits the response of the MDR1 promoter to TPA in K562 cells.	Tetradecanoylphorbol Acetate	138-141	WT1 transcription factor	Homo sapiens	59-62
10545022-0	1999	TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-alpha and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment.	Tetradecanoylphorbol Acetate	0-3	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	67-71
10392899-6	1999	We demonstrate here that the Wilms" tumor (WT) suppressor, WT1, a member of the EGR family, inhibits the response of the MDR1 promoter to TPA in K562 cells.	Tetradecanoylphorbol Acetate	138-141	ATP binding cassette subfamily B member 1	Homo sapiens	121-125
10545022-0	1999	TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-alpha and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	139-148
10545022-0	1999	TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-alpha and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	139-142
10545022-1	1999	We previously found that 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced invasiveness was associated with augmentation of cell motility but not that of metalloproteinase activity in a highly metastatic variant (L-10) of the human colon adenocarcinoma cell line RCM-1 and that this enhancement was possibly mediated by protein kinase C (PKC).	Tetradecanoylphorbol Acetate	25-61	protein kinase C alpha	Homo sapiens	340-343
10392899-7	1999	Inhibition is likely a direct effect of WT1 binding to the MDR1 promoter because: (a) WT1 expression does not inhibit the increase in EGR1 after TPA treatment; (b) inhibition by WT1 requires the zinc finger domain; (c) WT1 binds to MDR1 promoter sequences that bind EGR1 and are responsive to TPA; and (d) there is an inverse correlation between WT1 protein expression and MDR1 expression and promoter activity.	Tetradecanoylphorbol Acetate	293-296	WT1 transcription factor	Homo sapiens	40-43
10545022-1	1999	We previously found that 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced invasiveness was associated with augmentation of cell motility but not that of metalloproteinase activity in a highly metastatic variant (L-10) of the human colon adenocarcinoma cell line RCM-1 and that this enhancement was possibly mediated by protein kinase C (PKC).	Tetradecanoylphorbol Acetate	63-66	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	215-219
10545022-1	1999	We previously found that 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced invasiveness was associated with augmentation of cell motility but not that of metalloproteinase activity in a highly metastatic variant (L-10) of the human colon adenocarcinoma cell line RCM-1 and that this enhancement was possibly mediated by protein kinase C (PKC).	Tetradecanoylphorbol Acetate	63-66	protein kinase C alpha	Homo sapiens	340-343
10392899-7	1999	Inhibition is likely a direct effect of WT1 binding to the MDR1 promoter because: (a) WT1 expression does not inhibit the increase in EGR1 after TPA treatment; (b) inhibition by WT1 requires the zinc finger domain; (c) WT1 binds to MDR1 promoter sequences that bind EGR1 and are responsive to TPA; and (d) there is an inverse correlation between WT1 protein expression and MDR1 expression and promoter activity.	Tetradecanoylphorbol Acetate	293-296	ATP binding cassette subfamily B member 1	Homo sapiens	59-63
10545022-2	1999	In this study, we first intended to determine the specific isoforms of PKC involved in this TPA-enhanced L-10 cell motility that leads to invasion, and then investigated the way to inhibit the enhanced motility and invasion by using antisense oligodeoxynucleotides (ODN) targeting the isoform.	Tetradecanoylphorbol Acetate	92-95	protein kinase C alpha	Homo sapiens	71-74
10545022-2	1999	In this study, we first intended to determine the specific isoforms of PKC involved in this TPA-enhanced L-10 cell motility that leads to invasion, and then investigated the way to inhibit the enhanced motility and invasion by using antisense oligodeoxynucleotides (ODN) targeting the isoform.	Tetradecanoylphorbol Acetate	92-95	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	105-109
10545022-3	1999	An activator of conventional PKC isoforms (cPKC), thymeleatoxin, enhanced L-10 cell motility and invasion like TPA, and an inhibitor of cPKC, Go-6976, efficiently inhibited TPA-enhanced motility and invasion.	Tetradecanoylphorbol Acetate	111-114	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	74-78
10378896-3	1999	N-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA) induced tyrosine phosphorylation of 42- and 44-kDa proteins, which were identified as extracellular signal-regulated kinase (ERK), in human monocytes.	Tetradecanoylphorbol Acetate	51-76	mitogen-activated protein kinase 1	Homo sapiens	169-206
10545022-4	1999	TPA treatment induced a shift of PKC-alpha, but not other isoforms, from the cytosol to the membrane fraction, indicating the activation of the isoform.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	33-42
10545022-6	1999	Antisense ODNs specific for PKC-alpha efficiently reduced its expression at the protein levels and inhibited L-10 cell motility in the absence of TPA.	Tetradecanoylphorbol Acetate	146-149	protein kinase C alpha	Homo sapiens	28-37
10545022-7	1999	With TPA treatment, however, the remaining PKC-alpha was sufficient for activation leading to enhanced invasion.	Tetradecanoylphorbol Acetate	5-8	protein kinase C alpha	Homo sapiens	43-52
10342885-6	1999	D3 induction by TPA was blocked by GF 109203X, an inhibitor of protein kinase C. In addition, the effects of TPA and bFGF were partially prevented by PD 98059, a specific inhibitor of MEK and the Erk signaling cascade.	Tetradecanoylphorbol Acetate	16-19	Eph receptor B1	Rattus norvegicus	196-199
10342885-6	1999	D3 induction by TPA was blocked by GF 109203X, an inhibitor of protein kinase C. In addition, the effects of TPA and bFGF were partially prevented by PD 98059, a specific inhibitor of MEK and the Erk signaling cascade.	Tetradecanoylphorbol Acetate	109-112	Eph receptor B1	Rattus norvegicus	196-199
10342885-8	1999	In addition, the stimulatory effects of TPA and bFGF on D3 mRNA and activity appear to be mediated at least in part by activation of the MEK/Erk signaling cascade.	Tetradecanoylphorbol Acetate	40-43	Eph receptor B1	Rattus norvegicus	141-144
10336892-6	1999	In contrast, during megakaryocytic differentiation induced by the phorbol ester TPA, expression of HSF2 is rapidly down-regulated, leading to a complete loss of the HSF2 protein.	Tetradecanoylphorbol Acetate	80-83	heat shock transcription factor 2	Homo sapiens	99-103
10378896-3	1999	N-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA) induced tyrosine phosphorylation of 42- and 44-kDa proteins, which were identified as extracellular signal-regulated kinase (ERK), in human monocytes.	Tetradecanoylphorbol Acetate	51-76	mitogen-activated protein kinase 1	Homo sapiens	208-211
10336892-6	1999	In contrast, during megakaryocytic differentiation induced by the phorbol ester TPA, expression of HSF2 is rapidly down-regulated, leading to a complete loss of the HSF2 protein.	Tetradecanoylphorbol Acetate	80-83	heat shock transcription factor 2	Homo sapiens	165-169
10378896-3	1999	N-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA) induced tyrosine phosphorylation of 42- and 44-kDa proteins, which were identified as extracellular signal-regulated kinase (ERK), in human monocytes.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 1	Homo sapiens	169-206
10378896-3	1999	N-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA) induced tyrosine phosphorylation of 42- and 44-kDa proteins, which were identified as extracellular signal-regulated kinase (ERK), in human monocytes.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 1	Homo sapiens	208-211
10378896-7	1999	Superoxide release stimulated by FMLP was inhibited partially by PD98059 or SB203580, a specific inhibitor of ERK or p38 pathway, and was almost completely inhibited by the combination of both inhibitors, whereas PMA-induced superoxide release was resistant to these two inhibitors in monocytes.	Tetradecanoylphorbol Acetate	213-216	formyl peptide receptor 1	Homo sapiens	33-37
10336422-7	1999	Our data showed that LE135 and LE540 strongly repressed 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity in the presence of RARbeta and RXRalpha.	Tetradecanoylphorbol Acetate	56-92	retinoic acid receptor beta	Homo sapiens	134-141
10349842-3	1999	In glial cells, incubation with 6-OHDA and H2O2 induced a significant increase in the expression of gamma-glutamylcysteine synthetase (the rate-limiting enzyme in glutathione synthesis) mRNA, which correlated well with increased TPA-response element (TRE)-binding activity.	Tetradecanoylphorbol Acetate	229-232	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	100-133
10336459-6	1999	Compounds usually associated with PGHS-2 induction, including interleukin-1beta (IL-1beta), phorbol 12-myristate 13-acetate, and serum transiently down-regulated PGHS-2 expression.	Tetradecanoylphorbol Acetate	92-123	prostaglandin-endoperoxide synthase 2	Homo sapiens	34-40
10336429-3	1999	Here we report that when protein kinase C (PKC) pathways were activated in human glioblastoma U373 cells by phorbol 12-myristate 13-acetate (PMA), VEGF mRNA expression was up-regulated via a post-transcriptional mRNA stabilization mechanism.	Tetradecanoylphorbol Acetate	108-139	vascular endothelial growth factor A	Homo sapiens	147-151
10336459-6	1999	Compounds usually associated with PGHS-2 induction, including interleukin-1beta (IL-1beta), phorbol 12-myristate 13-acetate, and serum transiently down-regulated PGHS-2 expression.	Tetradecanoylphorbol Acetate	92-123	prostaglandin-endoperoxide synthase 2	Homo sapiens	162-168
10344742-6	1999	Higher concentrations of CAPE (10-20 microg/ml) suppressed the induction of COX-2 mRNA and protein mediated by TPA.	Tetradecanoylphorbol Acetate	111-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
10357879-4	1999	In contrast, treatment of cells with phorbol 12-myristate 13-acetate (PMA) strongly activated not only JNK but also ERK, while not affecting p38 kinase.	Tetradecanoylphorbol Acetate	37-68	mitogen-activated protein kinase 8	Homo sapiens	103-106
10357879-4	1999	In contrast, treatment of cells with phorbol 12-myristate 13-acetate (PMA) strongly activated not only JNK but also ERK, while not affecting p38 kinase.	Tetradecanoylphorbol Acetate	37-68	mitogen-activated protein kinase 1	Homo sapiens	116-119
10357879-4	1999	In contrast, treatment of cells with phorbol 12-myristate 13-acetate (PMA) strongly activated not only JNK but also ERK, while not affecting p38 kinase.	Tetradecanoylphorbol Acetate	70-73	mitogen-activated protein kinase 8	Homo sapiens	103-106
10357879-4	1999	In contrast, treatment of cells with phorbol 12-myristate 13-acetate (PMA) strongly activated not only JNK but also ERK, while not affecting p38 kinase.	Tetradecanoylphorbol Acetate	70-73	mitogen-activated protein kinase 1	Homo sapiens	116-119
10357879-6	1999	Interestingly, N6,O2-dibutylyl cAMP (DB-cAMP) significantly blocked SNP- or SNP plus PMA-induced activation of CPP32-like protease and the resulting induction of apoptosis.	Tetradecanoylphorbol Acetate	85-88	caspase 3	Homo sapiens	111-116
10233882-3	1999	We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor.	Tetradecanoylphorbol Acetate	131-162	CD34 molecule	Homo sapiens	50-54
10233882-3	1999	We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor.	Tetradecanoylphorbol Acetate	131-162	nuclear factor kappa B subunit 1	Homo sapiens	84-93
10344756-3	1999	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced immediate early genes, such as c-Jun, c-Fos, and Egr-1 in activated Ki-ras-disrupted clones, whereas c-Jun induction was rare in HCT116.	Tetradecanoylphorbol Acetate	38-41	PYD and CARD domain containing	Homo sapiens	79-83
10318773-3	1999	In addition, the expression of TR6 mRNA was shown in the endothelial cell line and induced by phorbol 12-myristate 13-acetate/ionomycin in Jurkat T leukemia cells.	Tetradecanoylphorbol Acetate	94-125	TNF receptor superfamily member 6b	Homo sapiens	31-34
10344756-4	1999	TPA induced both phosphorylation of stress-activated protein kinase kinase 1 (SEK1) and c-Jun NH2-terminal kinase (JNK) in the activated Ki-ras-disrupted clones but not in HCT116.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 4	Homo sapiens	36-76
10344756-4	1999	TPA induced both phosphorylation of stress-activated protein kinase kinase 1 (SEK1) and c-Jun NH2-terminal kinase (JNK) in the activated Ki-ras-disrupted clones but not in HCT116.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 4	Homo sapiens	78-82
10344756-4	1999	TPA induced both phosphorylation of stress-activated protein kinase kinase 1 (SEK1) and c-Jun NH2-terminal kinase (JNK) in the activated Ki-ras-disrupted clones but not in HCT116.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	88-113
10344756-4	1999	TPA induced both phosphorylation of stress-activated protein kinase kinase 1 (SEK1) and c-Jun NH2-terminal kinase (JNK) in the activated Ki-ras-disrupted clones but not in HCT116.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	115-118
10344756-5	1999	On the other hand, TPA-induced mitogen-activated protein kinase kinase 1/2 (MEK1/2)-extracellular signal-regulated kinase (ERK) activation was equally induced between HCT116 and the Ki-ras-disrupted clones.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase 1	Homo sapiens	123-126
10344756-6	1999	Furthermore, TPA-induced SEK1-JNK activation was observed in a DLD-1-derived activated Ki-ras-disrupted clone but not in DLD-1.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase kinase 4	Homo sapiens	25-29
10344756-6	1999	Furthermore, TPA-induced SEK1-JNK activation was observed in a DLD-1-derived activated Ki-ras-disrupted clone but not in DLD-1.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 8	Homo sapiens	30-33
10344756-7	1999	The TPA-induced SEK1-JNK activation in these disrupted clones was completely inhibited by the protein kinase C (PKC) inhibitor, GF109203X (1 microM), but not by another PKC inhibitor, H7 (50 microM), whereas TPA-induced MEK1/2-ERK activation was partially and completely inhibited by GF109203X (1 microM) and H7 (50 microM), respectively.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase kinase 4	Homo sapiens	16-20
10344756-7	1999	The TPA-induced SEK1-JNK activation in these disrupted clones was completely inhibited by the protein kinase C (PKC) inhibitor, GF109203X (1 microM), but not by another PKC inhibitor, H7 (50 microM), whereas TPA-induced MEK1/2-ERK activation was partially and completely inhibited by GF109203X (1 microM) and H7 (50 microM), respectively.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase 8	Homo sapiens	21-24
10344756-7	1999	The TPA-induced SEK1-JNK activation in these disrupted clones was completely inhibited by the protein kinase C (PKC) inhibitor, GF109203X (1 microM), but not by another PKC inhibitor, H7 (50 microM), whereas TPA-induced MEK1/2-ERK activation was partially and completely inhibited by GF109203X (1 microM) and H7 (50 microM), respectively.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase 1	Homo sapiens	227-230
10344756-7	1999	The TPA-induced SEK1-JNK activation in these disrupted clones was completely inhibited by the protein kinase C (PKC) inhibitor, GF109203X (1 microM), but not by another PKC inhibitor, H7 (50 microM), whereas TPA-induced MEK1/2-ERK activation was partially and completely inhibited by GF109203X (1 microM) and H7 (50 microM), respectively.	Tetradecanoylphorbol Acetate	208-211	mitogen-activated protein kinase kinase 4	Homo sapiens	16-20
10344756-0	1999	Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells.	Tetradecanoylphorbol Acetate	28-64	mitogen-activated protein kinase 8	Homo sapiens	91-116
10344756-3	1999	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced immediate early genes, such as c-Jun, c-Fos, and Egr-1 in activated Ki-ras-disrupted clones, whereas c-Jun induction was rare in HCT116.	Tetradecanoylphorbol Acetate	0-36	PYD and CARD domain containing	Homo sapiens	79-83
10318815-3	1999	We show that guanosine 5"-O-(3-thiotriphosphate)-stimulated phospholipase D (PLD) activity is inhibited in a time- and dose-dependent manner after an overnight treatment with LT. A similar dose response to the toxin was found when PLD activity was stimulated by phorbol 12-myristate 13-acetate via the protein kinase C pathway.	Tetradecanoylphorbol Acetate	262-293	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	60-75
10318815-3	1999	We show that guanosine 5"-O-(3-thiotriphosphate)-stimulated phospholipase D (PLD) activity is inhibited in a time- and dose-dependent manner after an overnight treatment with LT. A similar dose response to the toxin was found when PLD activity was stimulated by phorbol 12-myristate 13-acetate via the protein kinase C pathway.	Tetradecanoylphorbol Acetate	262-293	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	77-80
10325235-5	1999	Phorbol ester-sensitive PKC isoforms were detected at very low levels in caveolae fractions prepared from unstimulated cardiomyocytes; phorbol 12-myristate 13-acetate (PMA) (but not 4alpha-PMA, which does not activate PKC) recruited calcium-sensitive PKCalpha and novel PKCdelta and PKCepsilon to this compartment.	Tetradecanoylphorbol Acetate	135-166	protein kinase C alpha	Homo sapiens	24-27
10329111-2	1999	LPS pretreatment inhibits subsequent LPS-stimulated MAPK activation and TNF release and both were reversed if macrophages were treated with phorbol myristate acetate (PMA) before LPS stimulation.	Tetradecanoylphorbol Acetate	140-165	toll-like receptor 4	Mus musculus	0-3
10329111-2	1999	LPS pretreatment inhibits subsequent LPS-stimulated MAPK activation and TNF release and both were reversed if macrophages were treated with phorbol myristate acetate (PMA) before LPS stimulation.	Tetradecanoylphorbol Acetate	140-165	toll-like receptor 4	Mus musculus	37-40
10318836-7	1999	Here, we present evidence that phorbol 12-myristate 13-acetate (PMA)-induced down-regulation of the cell surface pool of CD4 occurs within the LDTI microdomains of T cells.	Tetradecanoylphorbol Acetate	31-62	CD4 molecule	Homo sapiens	121-124
10318836-7	1999	Here, we present evidence that phorbol 12-myristate 13-acetate (PMA)-induced down-regulation of the cell surface pool of CD4 occurs within the LDTI microdomains of T cells.	Tetradecanoylphorbol Acetate	64-67	CD4 molecule	Homo sapiens	121-124
10318836-9	1999	PMA-induced disruption of the CD4-Lck complex was rapid (within 5 min), and this disruption occurred within LDTI microdomains.	Tetradecanoylphorbol Acetate	0-3	CD4 molecule	Homo sapiens	30-33
10329111-2	1999	LPS pretreatment inhibits subsequent LPS-stimulated MAPK activation and TNF release and both were reversed if macrophages were treated with phorbol myristate acetate (PMA) before LPS stimulation.	Tetradecanoylphorbol Acetate	140-165	tumor necrosis factor	Mus musculus	72-75
10359012-4	1999	Treatment of cells with PD98059, a specific inhibitor of mitogen-activated protein kinase kinase (MEK), inhibited TPA-induced ERK2 activity.	Tetradecanoylphorbol Acetate	114-117	mitogen-activated protein kinase kinase 7	Homo sapiens	98-101
10329111-2	1999	LPS pretreatment inhibits subsequent LPS-stimulated MAPK activation and TNF release and both were reversed if macrophages were treated with phorbol myristate acetate (PMA) before LPS stimulation.	Tetradecanoylphorbol Acetate	140-165	toll-like receptor 4	Mus musculus	37-40
10329111-2	1999	LPS pretreatment inhibits subsequent LPS-stimulated MAPK activation and TNF release and both were reversed if macrophages were treated with phorbol myristate acetate (PMA) before LPS stimulation.	Tetradecanoylphorbol Acetate	167-170	toll-like receptor 4	Mus musculus	0-3
10329111-2	1999	LPS pretreatment inhibits subsequent LPS-stimulated MAPK activation and TNF release and both were reversed if macrophages were treated with phorbol myristate acetate (PMA) before LPS stimulation.	Tetradecanoylphorbol Acetate	167-170	toll-like receptor 4	Mus musculus	37-40
10329111-2	1999	LPS pretreatment inhibits subsequent LPS-stimulated MAPK activation and TNF release and both were reversed if macrophages were treated with phorbol myristate acetate (PMA) before LPS stimulation.	Tetradecanoylphorbol Acetate	167-170	tumor necrosis factor	Mus musculus	72-75
10329111-2	1999	LPS pretreatment inhibits subsequent LPS-stimulated MAPK activation and TNF release and both were reversed if macrophages were treated with phorbol myristate acetate (PMA) before LPS stimulation.	Tetradecanoylphorbol Acetate	167-170	toll-like receptor 4	Mus musculus	37-40
10224109-2	1999	PG490 inhibits interleukin(IL)-2 expression by normal human peripheral blood lymphocytes stimulated with phorbol 12-myristate 13-acetate (PMA) and antibody to CD3 (IC50 of 10 ng/ml), and with PMA and ionomycin (Iono, IC50 of 40 ng/ml).	Tetradecanoylphorbol Acetate	105-136	interleukin 2	Homo sapiens	15-32
10224109-2	1999	PG490 inhibits interleukin(IL)-2 expression by normal human peripheral blood lymphocytes stimulated with phorbol 12-myristate 13-acetate (PMA) and antibody to CD3 (IC50 of 10 ng/ml), and with PMA and ionomycin (Iono, IC50 of 40 ng/ml).	Tetradecanoylphorbol Acetate	138-141	interleukin 2	Homo sapiens	15-32
10362254-0	1999	In vivo analysis of the state of the human uPA enhancer following stimulation by TPA.	Tetradecanoylphorbol Acetate	81-84	plasminogen activator, urokinase	Homo sapiens	43-46
10362254-9	1999	These results indicate that TPA induces the binding of transcription factors to the uPA enhancer without chromatin remodelling of this region.	Tetradecanoylphorbol Acetate	28-31	plasminogen activator, urokinase	Homo sapiens	84-87
10359012-2	1999	Upon TPA treatment, the activity of ERK1 and ERK2 rapidly increased, with maximal induction between 1 and 3 h, while ERK2 protein levels remained constant.	Tetradecanoylphorbol Acetate	5-8	mitogen-activated protein kinase 3	Homo sapiens	36-40
10376809-5	1999	The study revealed that the fast onset of the fMLP-stimulated respiratory burst in comparison with PMA-stimulated response is not only due to the transient rise of [Ca2+]i, but is also due to the higher efficiency of diacylglycerol (DAG) in activating protein kinase c (PKC).	Tetradecanoylphorbol Acetate	99-102	formyl peptide receptor 1	Homo sapiens	46-50
10209967-5	1999	Exposure to the PKC inhibitors GF109203X, Go 6976 or Go 6983 caused a decrease whereas activation of PKC with 12-O-tetradecanoyl phorbol 13-acetate caused an increase in the number of neuroblastoma cells.	Tetradecanoylphorbol Acetate	110-147	protein kinase C alpha	Homo sapiens	101-104
10359012-1	1999	The purpose of this study was to evaluate whether the mitogen-activated protein kinase (MAPK) signaling pathway contributes to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mononuclear differentiation in the human myeloblastic leukemia ML-1 cells.	Tetradecanoylphorbol Acetate	127-163	mitogen-activated protein kinase 3	Homo sapiens	88-92
10359012-1	1999	The purpose of this study was to evaluate whether the mitogen-activated protein kinase (MAPK) signaling pathway contributes to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mononuclear differentiation in the human myeloblastic leukemia ML-1 cells.	Tetradecanoylphorbol Acetate	165-168	mitogen-activated protein kinase 3	Homo sapiens	88-92
10359012-2	1999	Upon TPA treatment, the activity of ERK1 and ERK2 rapidly increased, with maximal induction between 1 and 3 h, while ERK2 protein levels remained constant.	Tetradecanoylphorbol Acetate	5-8	mitogen-activated protein kinase 1	Homo sapiens	45-49
10359012-2	1999	Upon TPA treatment, the activity of ERK1 and ERK2 rapidly increased, with maximal induction between 1 and 3 h, while ERK2 protein levels remained constant.	Tetradecanoylphorbol Acetate	5-8	mitogen-activated protein kinase 1	Homo sapiens	117-121
10359012-3	1999	The activity of JNK1 was also significantly induced, with JNK1 protein levels increasing moderately during exposure to TPA.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 8	Homo sapiens	16-20
10359012-4	1999	Treatment of cells with PD98059, a specific inhibitor of mitogen-activated protein kinase kinase (MEK), inhibited TPA-induced ERK2 activity.	Tetradecanoylphorbol Acetate	114-117	mitogen-activated protein kinase 1	Homo sapiens	126-130
10359012-6	1999	We conclude that activation of the MEK/ERK signaling pathway is necessary for TPA-induced mononuclear cell differentiation.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase kinase 7	Homo sapiens	35-38
10359012-6	1999	We conclude that activation of the MEK/ERK signaling pathway is necessary for TPA-induced mononuclear cell differentiation.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 3	Homo sapiens	39-42
10359012-3	1999	The activity of JNK1 was also significantly induced, with JNK1 protein levels increasing moderately during exposure to TPA.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 8	Homo sapiens	58-62
10376804-3	1999	PD98059 suppressed the IL-6 synthesis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC) activator, or NaF, an activator of heterotrimeric GTP-binding protein, as well as the p42/p44 MAP kinase activation by TPA or NaF.	Tetradecanoylphorbol Acetate	49-85	interleukin 6	Mus musculus	23-27
10376804-3	1999	PD98059 suppressed the IL-6 synthesis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC) activator, or NaF, an activator of heterotrimeric GTP-binding protein, as well as the p42/p44 MAP kinase activation by TPA or NaF.	Tetradecanoylphorbol Acetate	87-90	interleukin 6	Mus musculus	23-27
10376804-3	1999	PD98059 suppressed the IL-6 synthesis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC) activator, or NaF, an activator of heterotrimeric GTP-binding protein, as well as the p42/p44 MAP kinase activation by TPA or NaF.	Tetradecanoylphorbol Acetate	237-240	interleukin 6	Mus musculus	23-27
10229912-6	1999	Conversely, insulin and 12-O-tetradecanoylphorbol-13-acetate (TPA) showed a partial inhibitory effect on NIS gene expression.	Tetradecanoylphorbol Acetate	24-60	solute carrier family 5 member 5	Rattus norvegicus	105-108
10229912-6	1999	Conversely, insulin and 12-O-tetradecanoylphorbol-13-acetate (TPA) showed a partial inhibitory effect on NIS gene expression.	Tetradecanoylphorbol Acetate	62-65	solute carrier family 5 member 5	Rattus norvegicus	105-108
10421840-11	1999	Phorbol ester TPA was found to stimulate the kinase activity of MOK, whereas serum stimulation, osmotic shock, or anisomycin treatment did not significantly activate MOK.	Tetradecanoylphorbol Acetate	14-17	MOK protein kinase	Homo sapiens	64-67
10329043-7	1999	RESULTS: The CCA reporter line exhibited a radiation dose-responsive induction of AP-1 activity that was decreased by 5 microM 9cRA and increased by 50 ng/ml TPA.	Tetradecanoylphorbol Acetate	158-161	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-86
10329043-8	1999	Simultaneous treatment with TPA and 9cRA prevented 9cRA repression of AP-1 and resulted in AP-1 activity above basal level.	Tetradecanoylphorbol Acetate	28-31	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	70-74
10329043-8	1999	Simultaneous treatment with TPA and 9cRA prevented 9cRA repression of AP-1 and resulted in AP-1 activity above basal level.	Tetradecanoylphorbol Acetate	28-31	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-95
10329043-11	1999	CONCLUSION: Although TPA prevented AP-1 repression by 9cRA, it did not prevent radiosensitization in CCA cultures, therefore the mechanism of radiosensitization of CCA by 9cRA is independent of AP-1 repression.	Tetradecanoylphorbol Acetate	21-24	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-39
10199555-6	1999	Similar to the IL-3 withdrawal, phorbol 12-myristate 13-acetate (PMA) dissolves actin-formed membrane ruffles and rounds the cells in the presence of IL-3.	Tetradecanoylphorbol Acetate	32-63	interleukin 3	Mus musculus	150-154
10235536-12	1999	Nitric oxide was also effective at suppressing increased VEGF expression secondan, to mutant ras and TPA.	Tetradecanoylphorbol Acetate	101-104	vascular endothelial growth factor A	Homo sapiens	57-61
10199555-6	1999	Similar to the IL-3 withdrawal, phorbol 12-myristate 13-acetate (PMA) dissolves actin-formed membrane ruffles and rounds the cells in the presence of IL-3.	Tetradecanoylphorbol Acetate	65-68	interleukin 3	Mus musculus	15-19
10199555-6	1999	Similar to the IL-3 withdrawal, phorbol 12-myristate 13-acetate (PMA) dissolves actin-formed membrane ruffles and rounds the cells in the presence of IL-3.	Tetradecanoylphorbol Acetate	65-68	interleukin 3	Mus musculus	150-154
10331492-4	1999	Sub-optimal concentrations of PMA (0.1-0.5 nM) inhibited the chemokinetic effect of 160 microU/mL insulin in a dose-dependent way.	Tetradecanoylphorbol Acetate	30-33	insulin	Homo sapiens	98-105
10363748-7	1999	MAIN OUTCOME MEASURES: Superoxide production in PMN induced by fMLP (a receptor ligand) and phorbol myristate acetate (PMA), which acts directly on protein kinase C. RESULTS: fMLP-induced superoxide generation in the malnourished patients was 55+/-5% of that of the controls.	Tetradecanoylphorbol Acetate	92-117	formyl peptide receptor 1	Homo sapiens	175-179
10331419-6	1999	Treatment of cells with phorbol 12-myristate 13-acetate, an activator of protein kinase C (PKC), reduced both insulin-stimulated PI 3-kinase activity by 57% and the association of IRS-2 to the p85 subunit of PI 3-kinase by 40%, whereas GF109203X, a specific inhibitor of PKC, partially prevented the inhibitory effect of ET-1 on insulin-induced PI 3-kinase activity.	Tetradecanoylphorbol Acetate	24-55	insulin	Homo sapiens	110-117
10363748-7	1999	MAIN OUTCOME MEASURES: Superoxide production in PMN induced by fMLP (a receptor ligand) and phorbol myristate acetate (PMA), which acts directly on protein kinase C. RESULTS: fMLP-induced superoxide generation in the malnourished patients was 55+/-5% of that of the controls.	Tetradecanoylphorbol Acetate	119-122	formyl peptide receptor 1	Homo sapiens	175-179
10331419-6	1999	Treatment of cells with phorbol 12-myristate 13-acetate, an activator of protein kinase C (PKC), reduced both insulin-stimulated PI 3-kinase activity by 57% and the association of IRS-2 to the p85 subunit of PI 3-kinase by 40%, whereas GF109203X, a specific inhibitor of PKC, partially prevented the inhibitory effect of ET-1 on insulin-induced PI 3-kinase activity.	Tetradecanoylphorbol Acetate	24-55	insulin	Homo sapiens	329-336
10210645-11	1999	Direct activation of PKC with PMA induced both NF-kappaB activation and TNF-alpha production by human monocytes.	Tetradecanoylphorbol Acetate	30-33	nuclear factor kappa B subunit 1	Homo sapiens	47-56
10217263-10	1999	Moreover, inhibition of ERK kinase activity by PD98059 dramatically reduced PMA-stimulated phosphorylation of ERKs and induction of LIF mRNA.	Tetradecanoylphorbol Acetate	76-79	mitogen-activated protein kinase 1	Homo sapiens	24-27
10217263-10	1999	Moreover, inhibition of ERK kinase activity by PD98059 dramatically reduced PMA-stimulated phosphorylation of ERKs and induction of LIF mRNA.	Tetradecanoylphorbol Acetate	76-79	mitogen-activated protein kinase 1	Homo sapiens	110-114
10200423-4	1999	Maximal activation of PKC using the phorbol esters, 4beta-phorbol 12-myristate, 13-acetate (PMA), phorbol 12, 13 dibutyrate (PDBu) and 12-deoxyphorbol 13-phenylacetate (dPPA) elicited a rapid, and sustained, inhibition of the outward steady-state voltage- and calcium- dependent potassium current predominantly carried through BK channels.	Tetradecanoylphorbol Acetate	92-95	protein kinase C, alpha	Mus musculus	22-25
10210645-11	1999	Direct activation of PKC with PMA induced both NF-kappaB activation and TNF-alpha production by human monocytes.	Tetradecanoylphorbol Acetate	30-33	tumor necrosis factor	Homo sapiens	72-81
10196299-3	1999	IFN-alpha inhibited in a dose-dependent manner the amplification of HHV-8 DNA in BCBL-1 cells induced to lytic infection with tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	126-155	interferon alpha 1	Homo sapiens	0-3
10196299-3	1999	IFN-alpha inhibited in a dose-dependent manner the amplification of HHV-8 DNA in BCBL-1 cells induced to lytic infection with tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	157-160	interferon alpha 1	Homo sapiens	0-3
10196299-7	1999	Conversely, the addition of anti-IFN-alpha Ab to TPA-induced BCBL-1 cells resulted in a larger number of mature enveloped particles and in a more extensive cytopathic effect due to the neutralization of the endogenous IFN produced by these cells.	Tetradecanoylphorbol Acetate	49-52	interferon alpha 1	Homo sapiens	33-42
10329260-5	1999	Phorbol myristate acetate, known to induce protease activity in other endothelial cell populations, stimulated MMP1, MMP9, and TIMP1 secretion in both NDEC and PEDEC.	Tetradecanoylphorbol Acetate	0-25	TIMP metallopeptidase inhibitor 1	Homo sapiens	127-132
10196299-7	1999	Conversely, the addition of anti-IFN-alpha Ab to TPA-induced BCBL-1 cells resulted in a larger number of mature enveloped particles and in a more extensive cytopathic effect due to the neutralization of the endogenous IFN produced by these cells.	Tetradecanoylphorbol Acetate	49-52	interferon alpha 1	Homo sapiens	33-36
10207106-7	1999	Like nrd1(+) for fission yeast differentiation, overexpressed ROD1 effectively blocks both 12-O-tetradecanoyl phorbol-13-acetate-induced megakaryocytic and sodium butyrate-induced erythroid differentiation of the K562 human leukemia cells without affecting their proliferative ability.	Tetradecanoylphorbol Acetate	91-128	polypyrimidine tract binding protein 3	Homo sapiens	62-66
10399131-5	1999	The proliferative response of nifedipine- or mibefradil-treated cells was restored by addition of phorbol-12-myristate-13-acetate (PMA), an exogenous PKC activator.	Tetradecanoylphorbol Acetate	98-129	proline rich transmembrane protein 2	Homo sapiens	150-153
10399131-5	1999	The proliferative response of nifedipine- or mibefradil-treated cells was restored by addition of phorbol-12-myristate-13-acetate (PMA), an exogenous PKC activator.	Tetradecanoylphorbol Acetate	131-134	proline rich transmembrane protein 2	Homo sapiens	150-153
10353535-8	1999	Both calcium ionophore, A23187, and the protein kinase C (PKC) activator phorbol-myristate-acetate (PMA) had a synergistic effect on IFN-gamma-induced EC apoptosis (p &lt; .05).	Tetradecanoylphorbol Acetate	73-98	interferon gamma	Homo sapiens	133-142
10353535-8	1999	Both calcium ionophore, A23187, and the protein kinase C (PKC) activator phorbol-myristate-acetate (PMA) had a synergistic effect on IFN-gamma-induced EC apoptosis (p &lt; .05).	Tetradecanoylphorbol Acetate	100-103	interferon gamma	Homo sapiens	133-142
10220459-3	1999	Aspirin and sodium salicylate at therapeutic concentrations equipotently blocked COX-2 mRNA and protein levels induced by interleukin-1beta and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	144-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
10696432-5	1999	By the treatment with phorbol 12-myristate 13-acetate (PMA) and ionomycin, normal CD4+ T cells were induced to express bcl-xS which can promote apoptosis, while bcl-xL was constitutively expressed in MD cell lines.	Tetradecanoylphorbol Acetate	22-53	BCL2 like 1	Homo sapiens	161-167
10092607-8	1999	However, treatment of myotubes with staurosporine or 12-O-tetradecanoylphorbol-13-acetate reduced the effect of A23187 on cytochrome c transactivation by 40-50%.	Tetradecanoylphorbol Acetate	53-89	cytochrome c, somatic	Homo sapiens	122-134
10411313-2	1999	TPA did not have any effect per se, but blunted the effect of PACAP-27 on both NPR-A density and NPR-A mRNA.	Tetradecanoylphorbol Acetate	0-3	natriuretic peptide receptor 1	Homo sapiens	79-84
10411313-2	1999	TPA did not have any effect per se, but blunted the effect of PACAP-27 on both NPR-A density and NPR-A mRNA.	Tetradecanoylphorbol Acetate	0-3	natriuretic peptide receptor 1	Homo sapiens	97-102
10696432-5	1999	By the treatment with phorbol 12-myristate 13-acetate (PMA) and ionomycin, normal CD4+ T cells were induced to express bcl-xS which can promote apoptosis, while bcl-xL was constitutively expressed in MD cell lines.	Tetradecanoylphorbol Acetate	55-58	BCL2 like 1	Homo sapiens	161-167
10198345-7	1999	We therefore determined whether these signal transduction elements were involved in PLD stimulation by 1,25(OH)2D3 or TPA.	Tetradecanoylphorbol Acetate	118-121	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	84-87
10198344-0	1999	1,25-dihydroxyvitamin D3 and TPA activate phospholipase D in Caco-2 cells: role of PKC-alpha.	Tetradecanoylphorbol Acetate	29-32	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	42-57
10198345-14	1999	These findings, taken together with those of the accompanying paper, indicate that although 1,25(OH)2D3 and TPA each activate PLD in Caco-2 cells in part via PKC-alpha, their stimulation of PLD differs in a number of important aspects, including the requirement for pp60(c-src) and RhoA in the activation of PLD by 1,25(OH)2D3, but not TPA.	Tetradecanoylphorbol Acetate	108-111	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-129
10198344-1	1999	1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] and 12-O-tetradecanoylphorbol 13-acetate (TPA) both activated phospholipase D (PLD) in Caco-2 cells.	Tetradecanoylphorbol Acetate	43-79	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	101-116
10198344-1	1999	1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] and 12-O-tetradecanoylphorbol 13-acetate (TPA) both activated phospholipase D (PLD) in Caco-2 cells.	Tetradecanoylphorbol Acetate	43-79	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	118-121
10198345-14	1999	These findings, taken together with those of the accompanying paper, indicate that although 1,25(OH)2D3 and TPA each activate PLD in Caco-2 cells in part via PKC-alpha, their stimulation of PLD differs in a number of important aspects, including the requirement for pp60(c-src) and RhoA in the activation of PLD by 1,25(OH)2D3, but not TPA.	Tetradecanoylphorbol Acetate	108-111	protein kinase C alpha	Homo sapiens	158-167
10198344-1	1999	1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] and 12-O-tetradecanoylphorbol 13-acetate (TPA) both activated phospholipase D (PLD) in Caco-2 cells.	Tetradecanoylphorbol Acetate	81-84	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	101-116
10198344-1	1999	1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] and 12-O-tetradecanoylphorbol 13-acetate (TPA) both activated phospholipase D (PLD) in Caco-2 cells.	Tetradecanoylphorbol Acetate	81-84	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	118-121
10198344-3	1999	1,25(OH)2D3 activated PKC-alpha, but not PKC-beta1, -betaII, -delta, or -zeta, whereas TPA activated PKC-alpha, -beta1, and -delta.	Tetradecanoylphorbol Acetate	87-90	protein kinase C alpha	Homo sapiens	101-110
10198344-3	1999	1,25(OH)2D3 activated PKC-alpha, but not PKC-beta1, -betaII, -delta, or -zeta, whereas TPA activated PKC-alpha, -beta1, and -delta.	Tetradecanoylphorbol Acetate	87-90	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	113-130
10198344-4	1999	Chronic treatment with TPA (1 microM, 24 h) significantly reduced the expression of PKC-alpha, -betaI, and -delta and markedly reduced the ability of 1,25(OH)2D3 or TPA to acutely stimulate PLD.	Tetradecanoylphorbol Acetate	23-26	protein kinase C alpha	Homo sapiens	84-113
10198345-14	1999	These findings, taken together with those of the accompanying paper, indicate that although 1,25(OH)2D3 and TPA each activate PLD in Caco-2 cells in part via PKC-alpha, their stimulation of PLD differs in a number of important aspects, including the requirement for pp60(c-src) and RhoA in the activation of PLD by 1,25(OH)2D3, but not TPA.	Tetradecanoylphorbol Acetate	108-111	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	190-193
10198345-14	1999	These findings, taken together with those of the accompanying paper, indicate that although 1,25(OH)2D3 and TPA each activate PLD in Caco-2 cells in part via PKC-alpha, their stimulation of PLD differs in a number of important aspects, including the requirement for pp60(c-src) and RhoA in the activation of PLD by 1,25(OH)2D3, but not TPA.	Tetradecanoylphorbol Acetate	108-111	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	271-276
10198345-14	1999	These findings, taken together with those of the accompanying paper, indicate that although 1,25(OH)2D3 and TPA each activate PLD in Caco-2 cells in part via PKC-alpha, their stimulation of PLD differs in a number of important aspects, including the requirement for pp60(c-src) and RhoA in the activation of PLD by 1,25(OH)2D3, but not TPA.	Tetradecanoylphorbol Acetate	108-111	ras homolog family member A	Homo sapiens	282-286
10198345-14	1999	These findings, taken together with those of the accompanying paper, indicate that although 1,25(OH)2D3 and TPA each activate PLD in Caco-2 cells in part via PKC-alpha, their stimulation of PLD differs in a number of important aspects, including the requirement for pp60(c-src) and RhoA in the activation of PLD by 1,25(OH)2D3, but not TPA.	Tetradecanoylphorbol Acetate	108-111	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	190-193
10198344-4	1999	Chronic treatment with TPA (1 microM, 24 h) significantly reduced the expression of PKC-alpha, -betaI, and -delta and markedly reduced the ability of 1,25(OH)2D3 or TPA to acutely stimulate PLD.	Tetradecanoylphorbol Acetate	23-26	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	190-193
10198345-15	1999	Moreover, the requirement for different signal transduction elements by 1,25(OH)2D3 and TPA to induce the stimulation of PLD may potentially underlie differences in the physiological effects of these agents in Caco-2 cells.	Tetradecanoylphorbol Acetate	88-91	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	121-124
10198344-4	1999	Chronic treatment with TPA (1 microM, 24 h) significantly reduced the expression of PKC-alpha, -betaI, and -delta and markedly reduced the ability of 1,25(OH)2D3 or TPA to acutely stimulate PLD.	Tetradecanoylphorbol Acetate	165-168	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	190-193
10198344-5	1999	Removal of Ca2+ from the medium, as well as preincubation of cells with Go-6976, an inhibitor of Ca2+-dependent PKC isoforms, significantly reduced the stimulation of PLD by 1,25(OH)2D3 or TPA.	Tetradecanoylphorbol Acetate	189-192	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	167-170
11225735-5	1999	NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells, and both VCAM-1 and ICAM-1 were significantly induced in these cells in response to tumor necrosis factor-alpha (TNF-alpha) and phorbol 12-myristate 13-acetate (PMA) stimulation, as studied by flow cytometry.	Tetradecanoylphorbol Acetate	233-264	nuclear factor kappa B subunit 1	Homo sapiens	0-9
10198344-7	1999	In addition, the activation of PLD by 1,25(OH)2D3 or TPA was markedly reduced or accentuated in stably transfected cells with inhibited or amplified PKC-alpha expression, respectively.	Tetradecanoylphorbol Acetate	53-56	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-34
10198344-7	1999	In addition, the activation of PLD by 1,25(OH)2D3 or TPA was markedly reduced or accentuated in stably transfected cells with inhibited or amplified PKC-alpha expression, respectively.	Tetradecanoylphorbol Acetate	53-56	protein kinase C alpha	Homo sapiens	149-158
10198344-8	1999	Taken together, these observations indicate that PKC-alpha is intimately involved in the stimulation of PLD in Caco-2 cells by 1,25(OH)2D3 or TPA.	Tetradecanoylphorbol Acetate	142-145	protein kinase C alpha	Homo sapiens	49-58
10198344-8	1999	Taken together, these observations indicate that PKC-alpha is intimately involved in the stimulation of PLD in Caco-2 cells by 1,25(OH)2D3 or TPA.	Tetradecanoylphorbol Acetate	142-145	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	104-107
10198345-5	1999	39): G993-G1004, 1999], activation of protein kinase C-alpha (PKC-alpha) was shown to be involved in the stimulation of phospholipase D (PLD) by 1,25-dihydroxyvitamin D3 [1, 25(OH)2D3] and 12-O-tetradecanoylphorbol 13-acetate (TPA) in Caco-2 cells.	Tetradecanoylphorbol Acetate	189-225	protein kinase C alpha	Homo sapiens	62-71
10198345-5	1999	39): G993-G1004, 1999], activation of protein kinase C-alpha (PKC-alpha) was shown to be involved in the stimulation of phospholipase D (PLD) by 1,25-dihydroxyvitamin D3 [1, 25(OH)2D3] and 12-O-tetradecanoylphorbol 13-acetate (TPA) in Caco-2 cells.	Tetradecanoylphorbol Acetate	189-225	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	137-140
10198345-5	1999	39): G993-G1004, 1999], activation of protein kinase C-alpha (PKC-alpha) was shown to be involved in the stimulation of phospholipase D (PLD) by 1,25-dihydroxyvitamin D3 [1, 25(OH)2D3] and 12-O-tetradecanoylphorbol 13-acetate (TPA) in Caco-2 cells.	Tetradecanoylphorbol Acetate	227-230	protein kinase C alpha	Homo sapiens	62-71
10198345-5	1999	39): G993-G1004, 1999], activation of protein kinase C-alpha (PKC-alpha) was shown to be involved in the stimulation of phospholipase D (PLD) by 1,25-dihydroxyvitamin D3 [1, 25(OH)2D3] and 12-O-tetradecanoylphorbol 13-acetate (TPA) in Caco-2 cells.	Tetradecanoylphorbol Acetate	227-230	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	137-140
10092592-5	1999	Pretreatment with acrolein completely blocked 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of NF-kappaB.	Tetradecanoylphorbol Acetate	46-82	nuclear factor kappa B subunit 1	Homo sapiens	111-120
10092592-5	1999	Pretreatment with acrolein completely blocked 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of NF-kappaB.	Tetradecanoylphorbol Acetate	84-87	nuclear factor kappa B subunit 1	Homo sapiens	111-120
11225735-5	1999	NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells, and both VCAM-1 and ICAM-1 were significantly induced in these cells in response to tumor necrosis factor-alpha (TNF-alpha) and phorbol 12-myristate 13-acetate (PMA) stimulation, as studied by flow cytometry.	Tetradecanoylphorbol Acetate	233-264	vascular cell adhesion molecule 1	Homo sapiens	114-120
10092592-7	1999	DEM also reduced NF-kappaB activation by 64% at 2 h post-treatment, with recovery to within 22% of control at 8 h. Both acrolein and DEM decreased NF-kappaB function approximately 50% at 2 h after treatment with TPA, as shown by a secreted alkaline phosphatase reporter assay.	Tetradecanoylphorbol Acetate	212-215	nuclear factor kappa B subunit 1	Homo sapiens	147-156
11225735-5	1999	NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells, and both VCAM-1 and ICAM-1 were significantly induced in these cells in response to tumor necrosis factor-alpha (TNF-alpha) and phorbol 12-myristate 13-acetate (PMA) stimulation, as studied by flow cytometry.	Tetradecanoylphorbol Acetate	233-264	tumor necrosis factor	Homo sapiens	218-227
11225735-5	1999	NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells, and both VCAM-1 and ICAM-1 were significantly induced in these cells in response to tumor necrosis factor-alpha (TNF-alpha) and phorbol 12-myristate 13-acetate (PMA) stimulation, as studied by flow cytometry.	Tetradecanoylphorbol Acetate	266-269	nuclear factor kappa B subunit 1	Homo sapiens	0-9
11225735-5	1999	NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells, and both VCAM-1 and ICAM-1 were significantly induced in these cells in response to tumor necrosis factor-alpha (TNF-alpha) and phorbol 12-myristate 13-acetate (PMA) stimulation, as studied by flow cytometry.	Tetradecanoylphorbol Acetate	266-269	vascular cell adhesion molecule 1	Homo sapiens	114-120
11225735-5	1999	NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells, and both VCAM-1 and ICAM-1 were significantly induced in these cells in response to tumor necrosis factor-alpha (TNF-alpha) and phorbol 12-myristate 13-acetate (PMA) stimulation, as studied by flow cytometry.	Tetradecanoylphorbol Acetate	266-269	tumor necrosis factor	Homo sapiens	189-216
11225735-5	1999	NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells, and both VCAM-1 and ICAM-1 were significantly induced in these cells in response to tumor necrosis factor-alpha (TNF-alpha) and phorbol 12-myristate 13-acetate (PMA) stimulation, as studied by flow cytometry.	Tetradecanoylphorbol Acetate	266-269	tumor necrosis factor	Homo sapiens	218-227
10209301-4	1999	Mesangial cells pretreated with PMA for 24 h to downregulate PKC demonstrated attenuated response to Ang II.	Tetradecanoylphorbol Acetate	32-35	angiotensinogen	Rattus norvegicus	101-107
10209302-4	1999	Pretreatment with 0.1-100 nM TNF-alpha for 60 min resulted in a significant decrease in 10 nM insulin- or 1 microM 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced [3H]2-deoxyglucose uptake without affecting basal glucose uptake.	Tetradecanoylphorbol Acetate	115-152	tumor necrosis factor	Rattus norvegicus	29-38
10221543-5	1999	Both p42/p44 MAP kinase activation and IL-6 synthesis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C-activating phorbol ester, were reduced by PD98059.	Tetradecanoylphorbol Acetate	65-101	interleukin 6	Mus musculus	39-43
10221543-5	1999	Both p42/p44 MAP kinase activation and IL-6 synthesis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C-activating phorbol ester, were reduced by PD98059.	Tetradecanoylphorbol Acetate	103-106	interleukin 6	Mus musculus	39-43
10233311-10	1999	In addition, stimulation of a human mast cell line HMC-1 with phorbol myristate acetate (PMA) (100 nmol/L) for periods of 2-24 h induced expression of IFN-gamma mRNA, which peaked at 24 h. When HMC-1 cells were stimulated with PMA (100 nmol/L) for periods of 0-3 days, the cells released IFN-gamma protein, peaking on day 1.	Tetradecanoylphorbol Acetate	62-87	interferon gamma	Homo sapiens	151-160
10233311-10	1999	In addition, stimulation of a human mast cell line HMC-1 with phorbol myristate acetate (PMA) (100 nmol/L) for periods of 2-24 h induced expression of IFN-gamma mRNA, which peaked at 24 h. When HMC-1 cells were stimulated with PMA (100 nmol/L) for periods of 0-3 days, the cells released IFN-gamma protein, peaking on day 1.	Tetradecanoylphorbol Acetate	62-87	interferon gamma	Homo sapiens	288-297
10233311-10	1999	In addition, stimulation of a human mast cell line HMC-1 with phorbol myristate acetate (PMA) (100 nmol/L) for periods of 2-24 h induced expression of IFN-gamma mRNA, which peaked at 24 h. When HMC-1 cells were stimulated with PMA (100 nmol/L) for periods of 0-3 days, the cells released IFN-gamma protein, peaking on day 1.	Tetradecanoylphorbol Acetate	89-92	interferon gamma	Homo sapiens	151-160
10233311-10	1999	In addition, stimulation of a human mast cell line HMC-1 with phorbol myristate acetate (PMA) (100 nmol/L) for periods of 2-24 h induced expression of IFN-gamma mRNA, which peaked at 24 h. When HMC-1 cells were stimulated with PMA (100 nmol/L) for periods of 0-3 days, the cells released IFN-gamma protein, peaking on day 1.	Tetradecanoylphorbol Acetate	89-92	interferon gamma	Homo sapiens	288-297
10233311-10	1999	In addition, stimulation of a human mast cell line HMC-1 with phorbol myristate acetate (PMA) (100 nmol/L) for periods of 2-24 h induced expression of IFN-gamma mRNA, which peaked at 24 h. When HMC-1 cells were stimulated with PMA (100 nmol/L) for periods of 0-3 days, the cells released IFN-gamma protein, peaking on day 1.	Tetradecanoylphorbol Acetate	227-230	interferon gamma	Homo sapiens	151-160
10233362-5	1999	Consistent with this observation, when THP-1 monocytic and HL-60 promyelocytic leukaemia cells expressing Ret were differentiated toward macrophages or granulocytes by treatment of 12-O-tetradecanoylphorbol-13-acetate (TPA) or all-trans retinoic acid (RA), Ret expression strikingly decreased during differentiation.	Tetradecanoylphorbol Acetate	181-217	GLI family zinc finger 2	Homo sapiens	39-44
10233362-5	1999	Consistent with this observation, when THP-1 monocytic and HL-60 promyelocytic leukaemia cells expressing Ret were differentiated toward macrophages or granulocytes by treatment of 12-O-tetradecanoylphorbol-13-acetate (TPA) or all-trans retinoic acid (RA), Ret expression strikingly decreased during differentiation.	Tetradecanoylphorbol Acetate	219-222	GLI family zinc finger 2	Homo sapiens	39-44
10319992-0	1999	Overexpression of c-Myc inhibits p21WAF1/CIP1 expression and induces S-phase entry in 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive human cancer cells.	Tetradecanoylphorbol Acetate	124-127	cyclin dependent kinase inhibitor 1A	Homo sapiens	41-45
10319992-5	1999	A time course after infection of TPA-arrested cells using a c-Myc-expressing adenovirus revealed that the inhibition of p21 expression preceded entry into S-phase.	Tetradecanoylphorbol Acetate	33-36	cyclin dependent kinase inhibitor 1A	Homo sapiens	120-123
10319997-1	1999	Investigation of 12-tetradecanoyl phorbol 13-acetate (TPA)-resistant U937 cell clones has demonstrated that the normal sustained p42 mitogen-activated protein kinase (p42MAPK) activation produced by TPA treatment is absent.	Tetradecanoylphorbol Acetate	17-52	mitogen-activated protein kinase 1	Homo sapiens	129-165
10319997-1	1999	Investigation of 12-tetradecanoyl phorbol 13-acetate (TPA)-resistant U937 cell clones has demonstrated that the normal sustained p42 mitogen-activated protein kinase (p42MAPK) activation produced by TPA treatment is absent.	Tetradecanoylphorbol Acetate	17-52	mitogen-activated protein kinase 1	Homo sapiens	167-174
10319997-1	1999	Investigation of 12-tetradecanoyl phorbol 13-acetate (TPA)-resistant U937 cell clones has demonstrated that the normal sustained p42 mitogen-activated protein kinase (p42MAPK) activation produced by TPA treatment is absent.	Tetradecanoylphorbol Acetate	54-57	mitogen-activated protein kinase 1	Homo sapiens	129-165
10319997-1	1999	Investigation of 12-tetradecanoyl phorbol 13-acetate (TPA)-resistant U937 cell clones has demonstrated that the normal sustained p42 mitogen-activated protein kinase (p42MAPK) activation produced by TPA treatment is absent.	Tetradecanoylphorbol Acetate	54-57	mitogen-activated protein kinase 1	Homo sapiens	167-174
10319997-1	1999	Investigation of 12-tetradecanoyl phorbol 13-acetate (TPA)-resistant U937 cell clones has demonstrated that the normal sustained p42 mitogen-activated protein kinase (p42MAPK) activation produced by TPA treatment is absent.	Tetradecanoylphorbol Acetate	199-202	mitogen-activated protein kinase 1	Homo sapiens	129-165
10319997-1	1999	Investigation of 12-tetradecanoyl phorbol 13-acetate (TPA)-resistant U937 cell clones has demonstrated that the normal sustained p42 mitogen-activated protein kinase (p42MAPK) activation produced by TPA treatment is absent.	Tetradecanoylphorbol Acetate	199-202	mitogen-activated protein kinase 1	Homo sapiens	167-174
10319997-2	1999	This is shown to be due to the inability of TPA to maintain activation of MAP/extracellular signal-regulated kinase kinase (MEK) and cRaf1.	Tetradecanoylphorbol Acetate	44-47	mitogen-activated protein kinase kinase 7	Homo sapiens	124-127
10319997-3	1999	A direct relationship between sustained p42MAPK activation and differentiation is provided by the demonstration that blockade of MEK activation by PD098059 prevents TPA-induced morphological differentiation of wild type U937 cells.	Tetradecanoylphorbol Acetate	165-168	mitogen-activated protein kinase 1	Homo sapiens	40-47
10319997-3	1999	A direct relationship between sustained p42MAPK activation and differentiation is provided by the demonstration that blockade of MEK activation by PD098059 prevents TPA-induced morphological differentiation of wild type U937 cells.	Tetradecanoylphorbol Acetate	165-168	mitogen-activated protein kinase kinase 7	Homo sapiens	129-132
10319997-4	1999	Using TPA-resistant clones, an involvement of microtubule reorganization and granule release is demonstrated by the ability of the microtubule depolymerizing agent nocodazole, to promote sustained p42MAPK activation in the presence of TPA.	Tetradecanoylphorbol Acetate	6-9	mitogen-activated protein kinase 1	Homo sapiens	197-204
10362070-8	1999	The treatment of endothelial cells with phorbol-myristate-acetate (PMA) upregulated the expression of u-PA and u-PAR antigens.	Tetradecanoylphorbol Acetate	40-65	plasminogen activator, urokinase	Homo sapiens	102-106
10362070-8	1999	The treatment of endothelial cells with phorbol-myristate-acetate (PMA) upregulated the expression of u-PA and u-PAR antigens.	Tetradecanoylphorbol Acetate	67-70	plasminogen activator, urokinase	Homo sapiens	102-106
10381626-5	1999	Exposure of TPA-differentiated U937 cells to 0.8 microg/ml cycloheximide for 24 h, that triggers apoptosis in 50% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Bcl-xL expression without modifying Bcl-2, Mcl-1 and Bax protein levels.	Tetradecanoylphorbol Acetate	12-15	caspase 3	Homo sapiens	131-155
10381626-5	1999	Exposure of TPA-differentiated U937 cells to 0.8 microg/ml cycloheximide for 24 h, that triggers apoptosis in 50% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Bcl-xL expression without modifying Bcl-2, Mcl-1 and Bax protein levels.	Tetradecanoylphorbol Acetate	12-15	cytochrome c, somatic	Homo sapiens	194-206
10381626-5	1999	Exposure of TPA-differentiated U937 cells to 0.8 microg/ml cycloheximide for 24 h, that triggers apoptosis in 50% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Bcl-xL expression without modifying Bcl-2, Mcl-1 and Bax protein levels.	Tetradecanoylphorbol Acetate	12-15	BCL2 like 1	Homo sapiens	221-227
10381626-5	1999	Exposure of TPA-differentiated U937 cells to 0.8 microg/ml cycloheximide for 24 h, that triggers apoptosis in 50% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Bcl-xL expression without modifying Bcl-2, Mcl-1 and Bax protein levels.	Tetradecanoylphorbol Acetate	12-15	BCL2 apoptosis regulator	Homo sapiens	257-262
10381626-5	1999	Exposure of TPA-differentiated U937 cells to 0.8 microg/ml cycloheximide for 24 h, that triggers apoptosis in 50% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Bcl-xL expression without modifying Bcl-2, Mcl-1 and Bax protein levels.	Tetradecanoylphorbol Acetate	12-15	BCL2 associated X, apoptosis regulator	Homo sapiens	274-277
10381626-7	1999	These results indicate that the apoptotic pathway that involves the release of cytochrome c from mitochondria and the cleavage of procaspases remains functional in TPA-differentiated cells.	Tetradecanoylphorbol Acetate	164-167	cytochrome c, somatic	Homo sapiens	79-91
10209302-4	1999	Pretreatment with 0.1-100 nM TNF-alpha for 60 min resulted in a significant decrease in 10 nM insulin- or 1 microM 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced [3H]2-deoxyglucose uptake without affecting basal glucose uptake.	Tetradecanoylphorbol Acetate	154-157	tumor necrosis factor	Rattus norvegicus	29-38
10209302-6	1999	10 nM TNF-alpha pretreatment also suppressed 10 nM insulin- and 1 microM TPA-induced increases in membrane-associated PKCbeta and PKCzeta.	Tetradecanoylphorbol Acetate	73-76	tumor necrosis factor	Rattus norvegicus	6-15
10229086-5	1999	Consistent with the presence of AP-1 proteins within the IL-2 NFAT complex, PDTC strongly enhanced phorbol 12-myristate 13-acetate/phytohemagglutinin-induced NFAT binding to the IL-2 NFAT enhancer and transcriptional activity of a reporter plasmid driven by this NFAT enhancer.	Tetradecanoylphorbol Acetate	99-130	interleukin 2	Homo sapiens	57-61
10229086-5	1999	Consistent with the presence of AP-1 proteins within the IL-2 NFAT complex, PDTC strongly enhanced phorbol 12-myristate 13-acetate/phytohemagglutinin-induced NFAT binding to the IL-2 NFAT enhancer and transcriptional activity of a reporter plasmid driven by this NFAT enhancer.	Tetradecanoylphorbol Acetate	99-130	interleukin 2	Homo sapiens	178-182
10084996-3	1999	Prevotella intermedia LPS, phorbol 12-myristate 13-acetate, and interleukin-6 also induced VEGF mRNA expression in HPC.	Tetradecanoylphorbol Acetate	27-58	vascular endothelial growth factor A	Homo sapiens	91-95
10217400-0	1999	Negative cooperativity between juxtaposed E-box and cAMP/TPA responsive elements in the cholecystokinin gene promoter.	Tetradecanoylphorbol Acetate	57-60	cholecystokinin	Homo sapiens	88-103
10217400-1	1999	The promoter of the cholecystokinin (CCK) gene possesses evolutionary conserved juxtaposed E-box and cAMP/TPA responsive elements (CRE/TRE).	Tetradecanoylphorbol Acetate	106-109	cholecystokinin	Homo sapiens	20-35
10217400-1	1999	The promoter of the cholecystokinin (CCK) gene possesses evolutionary conserved juxtaposed E-box and cAMP/TPA responsive elements (CRE/TRE).	Tetradecanoylphorbol Acetate	106-109	cholecystokinin	Homo sapiens	37-40
10460009-7	1999	Furthermore, this c-fos expression is not inhibited by cycloheximide, but is completely abolished by pretreatment with TPA, so that the c-fos gene is a direct target of TGF-beta1 signalling and PKC is involved in this c-fos induction.	Tetradecanoylphorbol Acetate	119-122	transforming growth factor, beta 1	Rattus norvegicus	169-178
10092317-5	1999	The regulation of Rab4 by cholecystokinin (CCK) and 12-O-tetradecanoyl-phorbol 13-acetate (TPA) was investigated by examining their effects on [32P]GTP binding rate into the Rab4 immunoprecipitates.	Tetradecanoylphorbol Acetate	52-89	RAB4A, member RAS oncogene family	Rattus norvegicus	18-22
10092317-5	1999	The regulation of Rab4 by cholecystokinin (CCK) and 12-O-tetradecanoyl-phorbol 13-acetate (TPA) was investigated by examining their effects on [32P]GTP binding rate into the Rab4 immunoprecipitates.	Tetradecanoylphorbol Acetate	52-89	RAB4A, member RAS oncogene family	Rattus norvegicus	174-178
10092317-5	1999	The regulation of Rab4 by cholecystokinin (CCK) and 12-O-tetradecanoyl-phorbol 13-acetate (TPA) was investigated by examining their effects on [32P]GTP binding rate into the Rab4 immunoprecipitates.	Tetradecanoylphorbol Acetate	91-94	RAB4A, member RAS oncogene family	Rattus norvegicus	18-22
10092317-5	1999	The regulation of Rab4 by cholecystokinin (CCK) and 12-O-tetradecanoyl-phorbol 13-acetate (TPA) was investigated by examining their effects on [32P]GTP binding rate into the Rab4 immunoprecipitates.	Tetradecanoylphorbol Acetate	91-94	RAB4A, member RAS oncogene family	Rattus norvegicus	174-178
10092317-9	1999	CCK and TPA increased GTP binding to Rab4.	Tetradecanoylphorbol Acetate	8-11	RAB4A, member RAS oncogene family	Rattus norvegicus	37-41
10527453-7	1999	However, despite the ability of phorbol myristate acetate (PMA) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells, PLD activity was not affected by IL-1beta.	Tetradecanoylphorbol Acetate	32-57	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	77-92
10563991-4	1999	On analysis of PKC activity with partial purified preparation, TPA (100 ng/mL) treatment was able to elevate membrane-associated PKC activity approximately 3-fold, and treatment with TF-3 (20 microM) and EGCG (20 microM) showed 94.5% and 9.4% suppression on TPA-induced PKC activity, respectively.	Tetradecanoylphorbol Acetate	63-66	protein kinase C, alpha	Mus musculus	15-18
10563991-4	1999	On analysis of PKC activity with partial purified preparation, TPA (100 ng/mL) treatment was able to elevate membrane-associated PKC activity approximately 3-fold, and treatment with TF-3 (20 microM) and EGCG (20 microM) showed 94.5% and 9.4% suppression on TPA-induced PKC activity, respectively.	Tetradecanoylphorbol Acetate	63-66	protein kinase C, alpha	Mus musculus	129-132
10563991-4	1999	On analysis of PKC activity with partial purified preparation, TPA (100 ng/mL) treatment was able to elevate membrane-associated PKC activity approximately 3-fold, and treatment with TF-3 (20 microM) and EGCG (20 microM) showed 94.5% and 9.4% suppression on TPA-induced PKC activity, respectively.	Tetradecanoylphorbol Acetate	63-66	protein kinase C, alpha	Mus musculus	129-132
10563991-5	1999	Translocation of PKCalpha protein from cytosol to membrane was detected in TPA-treated NIH3T3 cells, and TF-3 was able to block its translocation.	Tetradecanoylphorbol Acetate	75-78	protein kinase C, alpha	Mus musculus	17-25
10563991-6	1999	By in vitro kinase assay using myelin basic protein (MBP) as a PKC-specific substrate, we found that TPA treatment was able to increase PKC kinase activity by detection of phosphorylated MBP protein and TF-3 showed strongest inhibitory effect on its phosphorylation while EGCG was shown to be less effective.	Tetradecanoylphorbol Acetate	101-104	protein kinase C, alpha	Mus musculus	63-66
10563991-6	1999	By in vitro kinase assay using myelin basic protein (MBP) as a PKC-specific substrate, we found that TPA treatment was able to increase PKC kinase activity by detection of phosphorylated MBP protein and TF-3 showed strongest inhibitory effect on its phosphorylation while EGCG was shown to be less effective.	Tetradecanoylphorbol Acetate	101-104	protein kinase C, alpha	Mus musculus	136-139
10404956-5	1999	Differentiated THP-1, induced by adding phorbol 12-myristate 13-acetate for 24 h, were used as macrophages.	Tetradecanoylphorbol Acetate	40-71	GLI family zinc finger 2	Homo sapiens	15-20
10527453-7	1999	However, despite the ability of phorbol myristate acetate (PMA) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells, PLD activity was not affected by IL-1beta.	Tetradecanoylphorbol Acetate	32-57	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	94-97
10527453-7	1999	However, despite the ability of phorbol myristate acetate (PMA) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells, PLD activity was not affected by IL-1beta.	Tetradecanoylphorbol Acetate	59-62	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	77-92
10527453-7	1999	However, despite the ability of phorbol myristate acetate (PMA) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells, PLD activity was not affected by IL-1beta.	Tetradecanoylphorbol Acetate	59-62	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	94-97
10527453-7	1999	However, despite the ability of phorbol myristate acetate (PMA) to stimulate phospholipase D (PLD) and synthesis of phosphatidylethanol (PEt) in these cells, PLD activity was not affected by IL-1beta.	Tetradecanoylphorbol Acetate	59-62	interleukin 1 beta	Homo sapiens	191-199
10085163-4	1999	LPL activity was inhibited when TPA was added to cultures of 3T3-F442A and rat primary adipocytes.	Tetradecanoylphorbol Acetate	32-35	lipoprotein lipase	Rattus norvegicus	0-3
10085163-9	1999	LPL synthetic rate decreased after 6 h of TPA treatment.	Tetradecanoylphorbol Acetate	42-45	lipoprotein lipase	Rattus norvegicus	0-3
10085163-10	1999	Western blot analysis of cell lysates indicated a decrease in LPL mass after TPA treatment.	Tetradecanoylphorbol Acetate	77-80	lipoprotein lipase	Rattus norvegicus	62-65
10085148-5	1999	Stimulation of the cells with 12-O-tetradecanoylphorbol-13-acetate or phenylephrine induced transcription from the Glut1 promoter, which was inhibited by cotransfection with the mitogen-activated protein kinase phosphatases CL100 and MKP-3.	Tetradecanoylphorbol Acetate	30-66	dual specificity phosphatase 1	Homo sapiens	224-229
10085163-5	1999	The inhibitory effect of TPA on LPL activity was observed after 6 h of treatment, and was observed at a concentration of 6 nM.	Tetradecanoylphorbol Acetate	25-28	lipoprotein lipase	Rattus norvegicus	32-35
10085163-6	1999	100 nM TPA yielded maximal (80%) inhibition of LPL.	Tetradecanoylphorbol Acetate	7-10	lipoprotein lipase	Rattus norvegicus	47-50
10085163-8	1999	To determine whether TPA treatment of adipocytes decreased LPL synthesis, cells were labeled with [35S]methionine and LPL protein was immunoprecipitated.	Tetradecanoylphorbol Acetate	21-24	lipoprotein lipase	Rattus norvegicus	59-62
10085163-8	1999	To determine whether TPA treatment of adipocytes decreased LPL synthesis, cells were labeled with [35S]methionine and LPL protein was immunoprecipitated.	Tetradecanoylphorbol Acetate	21-24	lipoprotein lipase	Rattus norvegicus	118-121
10090765-2	1999	Previously we have demonstrated that protein kinase Calpha (PKCalpha) directly interacts with phospholipase D1 (PLD1), activating the enzymatic activity of PLD1 in the presence of phorbol 12-myristate 13-acetate (PMA) [Lee, T. G., et al.	Tetradecanoylphorbol Acetate	180-211	phospholipase D1	Rattus norvegicus	94-110
10090765-2	1999	Previously we have demonstrated that protein kinase Calpha (PKCalpha) directly interacts with phospholipase D1 (PLD1), activating the enzymatic activity of PLD1 in the presence of phorbol 12-myristate 13-acetate (PMA) [Lee, T. G., et al.	Tetradecanoylphorbol Acetate	180-211	phospholipase D1	Rattus norvegicus	112-116
10090765-2	1999	Previously we have demonstrated that protein kinase Calpha (PKCalpha) directly interacts with phospholipase D1 (PLD1), activating the enzymatic activity of PLD1 in the presence of phorbol 12-myristate 13-acetate (PMA) [Lee, T. G., et al.	Tetradecanoylphorbol Acetate	180-211	phospholipase D1	Rattus norvegicus	156-160
10090765-2	1999	Previously we have demonstrated that protein kinase Calpha (PKCalpha) directly interacts with phospholipase D1 (PLD1), activating the enzymatic activity of PLD1 in the presence of phorbol 12-myristate 13-acetate (PMA) [Lee, T. G., et al.	Tetradecanoylphorbol Acetate	213-216	phospholipase D1	Rattus norvegicus	94-110
10090765-2	1999	Previously we have demonstrated that protein kinase Calpha (PKCalpha) directly interacts with phospholipase D1 (PLD1), activating the enzymatic activity of PLD1 in the presence of phorbol 12-myristate 13-acetate (PMA) [Lee, T. G., et al.	Tetradecanoylphorbol Acetate	213-216	phospholipase D1	Rattus norvegicus	112-116
10090765-2	1999	Previously we have demonstrated that protein kinase Calpha (PKCalpha) directly interacts with phospholipase D1 (PLD1), activating the enzymatic activity of PLD1 in the presence of phorbol 12-myristate 13-acetate (PMA) [Lee, T. G., et al.	Tetradecanoylphorbol Acetate	213-216	phospholipase D1	Rattus norvegicus	156-160
10090765-10	1999	PMA elicits translocation of PKCalpha to the CEMs, inducing PLD activation through the interaction of PKCalpha with PLD1 in the CEMs.	Tetradecanoylphorbol Acetate	0-3	phospholipase D1	Rattus norvegicus	116-120
10090770-6	1999	The association of PKCalpha with membranes containing 12-O-tetradecanoylphorbol 13-acetate (TPA) or 1, 2-dioleoylglycerol (DAG), determined from tryptophan to dansyl-PE resonance energy transfer (RET) measurements, was found to occur at relatively low Ca2+ levels (&lt;/=1 microM).	Tetradecanoylphorbol Acetate	54-90	protein kinase C alpha	Homo sapiens	19-27
10090770-6	1999	The association of PKCalpha with membranes containing 12-O-tetradecanoylphorbol 13-acetate (TPA) or 1, 2-dioleoylglycerol (DAG), determined from tryptophan to dansyl-PE resonance energy transfer (RET) measurements, was found to occur at relatively low Ca2+ levels (&lt;/=1 microM).	Tetradecanoylphorbol Acetate	92-95	protein kinase C alpha	Homo sapiens	19-27
10090770-10	1999	Also, it was found that incubation of the enzyme with TPA alone resulted in a time-dependent increase in the Ca2+-independent PKCalpha activity, the rate and extent of which was further enhanced upon coaddition with DAG.	Tetradecanoylphorbol Acetate	54-57	protein kinase C alpha	Homo sapiens	126-134
10090770-11	1999	Tauhe results suggest that the enhanced level of activity induced by coaddition of DAG and TPA involves both Ca2+-dependent and Ca2+-independent activating conformational changes which result in active conformers of PKCalpha distinct from those formed by interaction with either activator separately.	Tetradecanoylphorbol Acetate	91-94	protein kinase C alpha	Homo sapiens	216-224
10079079-1	1999	We previously observed that IFN gamma-inducible expression of the human MHC class II, HLA-DR alpha, gene was enhanced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) only in human monocytic leukemia THP-1 cells, but not in HeLa cells.	Tetradecanoylphorbol Acetate	136-172	interferon gamma	Homo sapiens	28-37
10079079-1	1999	We previously observed that IFN gamma-inducible expression of the human MHC class II, HLA-DR alpha, gene was enhanced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) only in human monocytic leukemia THP-1 cells, but not in HeLa cells.	Tetradecanoylphorbol Acetate	174-177	interferon gamma	Homo sapiens	28-37
10368656-6	1999	Treatment with TPA prior to KH1060 resulted in only slight production of TNF; however, treatment with KH1060 preceding TPA induced a substantial amount of TNF.	Tetradecanoylphorbol Acetate	15-18	tumor necrosis factor	Homo sapiens	73-76
10092052-4	1999	The increased production of IL-1beta induced by this concentration of DEP was further enhanced by the presence of phorbol 12-myristate 13-acetate (PMA), although PMA alone did not affect the levels of IL-1beta.	Tetradecanoylphorbol Acetate	114-145	interleukin 1 beta	Homo sapiens	28-36
10092052-4	1999	The increased production of IL-1beta induced by this concentration of DEP was further enhanced by the presence of phorbol 12-myristate 13-acetate (PMA), although PMA alone did not affect the levels of IL-1beta.	Tetradecanoylphorbol Acetate	147-150	interleukin 1 beta	Homo sapiens	28-36
10092052-4	1999	The increased production of IL-1beta induced by this concentration of DEP was further enhanced by the presence of phorbol 12-myristate 13-acetate (PMA), although PMA alone did not affect the levels of IL-1beta.	Tetradecanoylphorbol Acetate	162-165	interleukin 1 beta	Homo sapiens	28-36
10092052-9	1999	Although basal levels of TNF-alpha in the culture supernatants were increased after stimulation with PMA, neither pollutant alone nor combination with PMA affected the levels of TNF-alpha.	Tetradecanoylphorbol Acetate	101-104	tumor necrosis factor	Homo sapiens	25-34
10092775-2	1999	We have previously shown that protein kinase C (PKC) activation (with phorbol ester (PMA) alone) specifically induces differentiation of primary human CD34+ hemopoietic progenitor cells (HPC) to mature DC.	Tetradecanoylphorbol Acetate	85-88	CD34 molecule	Homo sapiens	151-155
10066763-4	1999	It was found that the activation of short term (2-min) Na/Pi uptake by PMA is abolished when cells are infected with amphotropic murine retrovirus (binds Pit-2 receptor) but not with gibbon ape leukemia retrovirus (binds Pit-1 receptor), indicating that Pit-2 is the form of Na/Pi transporter/viral receptor regulated by PKC.	Tetradecanoylphorbol Acetate	71-74	POU domain, class 1, transcription factor 1	Mus musculus	221-226
10037704-2	1999	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is a potent inducer of keratinocyte differentiation and of involucrin gene expression.	Tetradecanoylphorbol Acetate	18-54	involucrin	Homo sapiens	120-130
10037704-2	1999	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is a potent inducer of keratinocyte differentiation and of involucrin gene expression.	Tetradecanoylphorbol Acetate	56-59	involucrin	Homo sapiens	120-130
10037704-4	1999	Mutation of the C/EBP site results in the loss of basal and TPA-responsive activity.	Tetradecanoylphorbol Acetate	60-63	CCAAT enhancer binding protein alpha	Homo sapiens	16-21
10037704-5	1999	Gel mobility supershift analysis shows that C/EBPalpha binding to this site is increased by TPA treatment.	Tetradecanoylphorbol Acetate	92-95	CCAAT enhancer binding protein alpha	Homo sapiens	44-54
10037704-8	1999	Transfection experiments using GADD153 to create C/EBP-null conditions confirm that C/EBP factors are absolutely required for promoter activity and TPA responsiveness.	Tetradecanoylphorbol Acetate	148-151	DNA damage inducible transcript 3	Homo sapiens	31-38
10037704-8	1999	Transfection experiments using GADD153 to create C/EBP-null conditions confirm that C/EBP factors are absolutely required for promoter activity and TPA responsiveness.	Tetradecanoylphorbol Acetate	148-151	CCAAT enhancer binding protein alpha	Homo sapiens	49-54
10037704-8	1999	Transfection experiments using GADD153 to create C/EBP-null conditions confirm that C/EBP factors are absolutely required for promoter activity and TPA responsiveness.	Tetradecanoylphorbol Acetate	148-151	CCAAT enhancer binding protein alpha	Homo sapiens	84-89
10037704-9	1999	C/EBPbeta and C/EBPdelta inhibit both TPA- and C/EBPalpha-dependent promoter activation, indicating functional differences among C/EBP family members.	Tetradecanoylphorbol Acetate	38-41	CCAAT enhancer binding protein alpha	Homo sapiens	0-5
10037704-10	1999	These results suggest that C/EBP transcription factor activity is necessary for basal promoter activity and TPA response of the involucrin gene.	Tetradecanoylphorbol Acetate	108-111	CCAAT enhancer binding protein alpha	Homo sapiens	27-32
10037704-10	1999	These results suggest that C/EBP transcription factor activity is necessary for basal promoter activity and TPA response of the involucrin gene.	Tetradecanoylphorbol Acetate	108-111	involucrin	Homo sapiens	128-138
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Tetradecanoylphorbol Acetate	53-84	protein kinase C alpha	Homo sapiens	38-41
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Tetradecanoylphorbol Acetate	53-84	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	102-117
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Tetradecanoylphorbol Acetate	53-84	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-122
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Tetradecanoylphorbol Acetate	53-84	protein kinase C alpha	Homo sapiens	222-231
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Tetradecanoylphorbol Acetate	86-89	protein kinase C alpha	Homo sapiens	38-41
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Tetradecanoylphorbol Acetate	86-89	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	102-117
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Tetradecanoylphorbol Acetate	86-89	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	119-122
10049506-1	1999	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms.	Tetradecanoylphorbol Acetate	86-89	protein kinase C alpha	Homo sapiens	222-231
10049506-7	1999	Interestingly, although PKC-alpha also mediates the stimulatory effect of PMA on the synthesis of PtdCho by a phosphorylation mechanism, overexpression of holo PKC-epsilon or its regulatory domain fragments did not affect PMA-induced PtdCho synthesis.	Tetradecanoylphorbol Acetate	74-77	protein kinase C alpha	Homo sapiens	24-33
10368656-6	1999	Treatment with TPA prior to KH1060 resulted in only slight production of TNF; however, treatment with KH1060 preceding TPA induced a substantial amount of TNF.	Tetradecanoylphorbol Acetate	119-122	tumor necrosis factor	Homo sapiens	155-158
10190560-1	1999	We investigated whether curcumin, a chemopreventive agent, inhibited chenodeoxycholate (CD)- or phorbol ester (PMA)-mediated induction of cyclooxygenase-2 (COX-2) in several gastrointestinal cell lines (SK-GT-4, SCC450, IEC-18 and HCA-7).	Tetradecanoylphorbol Acetate	111-114	prostaglandin-endoperoxide synthase 2	Homo sapiens	138-154
10217536-11	1999	In accordance with these effects of MAFP, PKC activator phorbol 12-myristate 13-acetate (PMA) increased PGE2 release and caused activation of PKCbeta, ERKs and p38 MAPK.	Tetradecanoylphorbol Acetate	56-87	mitogen-activated protein kinase 1	Mus musculus	151-155
10217536-11	1999	In accordance with these effects of MAFP, PKC activator phorbol 12-myristate 13-acetate (PMA) increased PGE2 release and caused activation of PKCbeta, ERKs and p38 MAPK.	Tetradecanoylphorbol Acetate	89-92	mitogen-activated protein kinase 1	Mus musculus	151-155
10190560-2	1999	Treatment with curcumin suppressed CD- and PMA-mediated induction of COX-2 protein and synthesis of prostaglandin E2.	Tetradecanoylphorbol Acetate	43-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	69-74
10190560-4	1999	Nuclear run-offs revealed increased rates of COX-2 transcription after treatment with CD or PMA and these effects were inhibited by curcumin.	Tetradecanoylphorbol Acetate	92-95	prostaglandin-endoperoxide synthase 2	Homo sapiens	45-50
10193428-2	1999	MS progressive patients showed an increased number of cells producing interferon-gamma (IFN-gamma) after activation with phorbol 12-myristate 13-acetate and ionomycin, compared with patients with clinically inactive forms (P &lt; 0001) and with healthy controls (P = 0001).	Tetradecanoylphorbol Acetate	121-152	interferon gamma	Homo sapiens	70-86
10193428-2	1999	MS progressive patients showed an increased number of cells producing interferon-gamma (IFN-gamma) after activation with phorbol 12-myristate 13-acetate and ionomycin, compared with patients with clinically inactive forms (P &lt; 0001) and with healthy controls (P = 0001).	Tetradecanoylphorbol Acetate	121-152	interferon gamma	Homo sapiens	88-97
10067856-8	1999	Similarly, activation of PK-C, by treatment with phorbol 12-myristate 13-acetate, elicited only a minimal increase in constitutive receptor endocytosis; and blockade of the PK-C pathway, by treatment with a bisindolylmaleimide, failed to inhibit agonist-induced receptor endocytosis.	Tetradecanoylphorbol Acetate	49-80	proline rich transmembrane protein 2	Homo sapiens	25-29
10067831-4	1999	On the contrary, the phorbol ester, 12-O-tetradecanoyl-phorbol 13-acetate (1-100 nM) prevented TSH-induced follicle formation and strongly increased the synthesis of TSP1.	Tetradecanoylphorbol Acetate	36-73	thrombospondin 1	Homo sapiens	166-170
10067831-6	1999	Transforming growth factor-beta, like 12-O-tetradecanoyl-phorbol 13-acetate, increased TSP1 synthesis and prevented TSH-induced follicle formation.	Tetradecanoylphorbol Acetate	38-75	transforming growth factor beta 1	Homo sapiens	0-31
10067831-6	1999	Transforming growth factor-beta, like 12-O-tetradecanoyl-phorbol 13-acetate, increased TSP1 synthesis and prevented TSH-induced follicle formation.	Tetradecanoylphorbol Acetate	38-75	thrombospondin 1	Homo sapiens	87-91
10087440-6	1999	Activation of protein kinase C (PKC) by phorbol-12-myristate-13-acetate (PMA) increased PLD activity that was effectively blocked by the PKC inhibitors calphostin C (10(-8) to 10(-6) M) and GFX (10(-8) to 10(-6) M).	Tetradecanoylphorbol Acetate	40-71	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	88-91
10092074-4	1999	Moreover, long-term treatment of Th1 cells with phorbol 12-myristate 13-acetate (PMA) caused the abrogation of anti-CD3-induced AICD in parallel with the disappearance of PMA-sensitive PKC isoforms such as PKC alpha, gamma, epsilon and theta.	Tetradecanoylphorbol Acetate	48-79	negative elongation factor complex member C/D, Th1l	Mus musculus	33-36
10092074-4	1999	Moreover, long-term treatment of Th1 cells with phorbol 12-myristate 13-acetate (PMA) caused the abrogation of anti-CD3-induced AICD in parallel with the disappearance of PMA-sensitive PKC isoforms such as PKC alpha, gamma, epsilon and theta.	Tetradecanoylphorbol Acetate	48-79	protein kinase C, alpha	Mus musculus	185-188
10092074-4	1999	Moreover, long-term treatment of Th1 cells with phorbol 12-myristate 13-acetate (PMA) caused the abrogation of anti-CD3-induced AICD in parallel with the disappearance of PMA-sensitive PKC isoforms such as PKC alpha, gamma, epsilon and theta.	Tetradecanoylphorbol Acetate	48-79	protein kinase C, alpha	Mus musculus	206-241
10092074-4	1999	Moreover, long-term treatment of Th1 cells with phorbol 12-myristate 13-acetate (PMA) caused the abrogation of anti-CD3-induced AICD in parallel with the disappearance of PMA-sensitive PKC isoforms such as PKC alpha, gamma, epsilon and theta.	Tetradecanoylphorbol Acetate	81-84	negative elongation factor complex member C/D, Th1l	Mus musculus	33-36
10092074-4	1999	Moreover, long-term treatment of Th1 cells with phorbol 12-myristate 13-acetate (PMA) caused the abrogation of anti-CD3-induced AICD in parallel with the disappearance of PMA-sensitive PKC isoforms such as PKC alpha, gamma, epsilon and theta.	Tetradecanoylphorbol Acetate	81-84	protein kinase C, alpha	Mus musculus	185-188
10092074-4	1999	Moreover, long-term treatment of Th1 cells with phorbol 12-myristate 13-acetate (PMA) caused the abrogation of anti-CD3-induced AICD in parallel with the disappearance of PMA-sensitive PKC isoforms such as PKC alpha, gamma, epsilon and theta.	Tetradecanoylphorbol Acetate	81-84	protein kinase C, alpha	Mus musculus	206-241
10092074-4	1999	Moreover, long-term treatment of Th1 cells with phorbol 12-myristate 13-acetate (PMA) caused the abrogation of anti-CD3-induced AICD in parallel with the disappearance of PMA-sensitive PKC isoforms such as PKC alpha, gamma, epsilon and theta.	Tetradecanoylphorbol Acetate	171-174	negative elongation factor complex member C/D, Th1l	Mus musculus	33-36
10092074-4	1999	Moreover, long-term treatment of Th1 cells with phorbol 12-myristate 13-acetate (PMA) caused the abrogation of anti-CD3-induced AICD in parallel with the disappearance of PMA-sensitive PKC isoforms such as PKC alpha, gamma, epsilon and theta.	Tetradecanoylphorbol Acetate	171-174	protein kinase C, alpha	Mus musculus	185-188
10092074-4	1999	Moreover, long-term treatment of Th1 cells with phorbol 12-myristate 13-acetate (PMA) caused the abrogation of anti-CD3-induced AICD in parallel with the disappearance of PMA-sensitive PKC isoforms such as PKC alpha, gamma, epsilon and theta.	Tetradecanoylphorbol Acetate	171-174	protein kinase C, alpha	Mus musculus	206-241
10073603-7	1999	This was also associated with increased cytoplasmic IL-13 expression in phorbol myristate acetate/ionomycin-activated CD3+ cells (6.66+/-3.39%) from patients with nephrotic relapse compared to remission (2.59+/-1.35%) (P &lt; 0.0001).	Tetradecanoylphorbol Acetate	72-97	interleukin 13	Homo sapiens	52-57
10087440-6	1999	Activation of protein kinase C (PKC) by phorbol-12-myristate-13-acetate (PMA) increased PLD activity that was effectively blocked by the PKC inhibitors calphostin C (10(-8) to 10(-6) M) and GFX (10(-8) to 10(-6) M).	Tetradecanoylphorbol Acetate	73-76	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	88-91
10077003-3	1999	bFGF and forskolin stimulated promoter activity via a cAMP response element (CRE)/12-O-tetradecanoylphorbol-13-acetate response element (TRE) located 80 bp upstream from the transcription initiation site.	Tetradecanoylphorbol Acetate	82-118	fibroblast growth factor 2	Homo sapiens	0-4
10051531-5	1999	Marked or slight activation, respectively, of p44/42 MAPK or p38 was also seen after 10-min treatment with 12-O-tetradecanoylphorbol-13-acetate, but c-Jun NH2-terminal kinase activation did not occur.	Tetradecanoylphorbol Acetate	107-143	mitogen-activated protein kinase 14	Homo sapiens	61-64
10023015-8	1999	Especially in kidney cell lines, the levels of granulocyte-macrophage-CSF (GM-CSF), M-CSF and IL-6 were further strongly increased by the TPA and IL-1 pretreatment.	Tetradecanoylphorbol Acetate	138-141	interleukin 6	Homo sapiens	94-98
10047452-3	1999	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) produced a dramatic induction of the invasiveness of these cells (18-fold), an effect that concurrent treatment with the PKC inhibitor Bryostatin-1 was able to block.	Tetradecanoylphorbol Acetate	15-51	proline rich transmembrane protein 2	Homo sapiens	179-182
10047452-3	1999	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) produced a dramatic induction of the invasiveness of these cells (18-fold), an effect that concurrent treatment with the PKC inhibitor Bryostatin-1 was able to block.	Tetradecanoylphorbol Acetate	53-56	proline rich transmembrane protein 2	Homo sapiens	179-182
10080543-10	1999	Experiments performed in the presence of rolipram indicated that ConA and TPA stimulated both the rolipram-sensitive PDE4 and the rolipram-insensitive PDE activities, OKT3 being more active on PDE4.	Tetradecanoylphorbol Acetate	74-77	phosphodiesterase 4A	Homo sapiens	117-121
10080543-10	1999	Experiments performed in the presence of rolipram indicated that ConA and TPA stimulated both the rolipram-sensitive PDE4 and the rolipram-insensitive PDE activities, OKT3 being more active on PDE4.	Tetradecanoylphorbol Acetate	74-77	phosphodiesterase 4A	Homo sapiens	193-197
10102471-11	1999	PD 098059 and U0126, both highly specific MEK inhibitors, efficiently prevented PMA-induced PAI-1 synthesis (mRNA and protein levels) and cell adhesion whereas SB203580, a specific inhibitor of stress-activated MAPK p38, did not.	Tetradecanoylphorbol Acetate	80-83	mitogen-activated protein kinase kinase 7	Homo sapiens	42-45
10102471-11	1999	PD 098059 and U0126, both highly specific MEK inhibitors, efficiently prevented PMA-induced PAI-1 synthesis (mRNA and protein levels) and cell adhesion whereas SB203580, a specific inhibitor of stress-activated MAPK p38, did not.	Tetradecanoylphorbol Acetate	80-83	mitogen-activated protein kinase 14	Homo sapiens	216-219
10102471-13	1999	In conclusion, we propose that the pathway PKCbeta-MEK-MAPK p42 is a potential linear route for PAI-1 synthesis leading to morphological changes and adherence linked to PMA-induced differentiation in HL-60 cells.	Tetradecanoylphorbol Acetate	169-172	mitogen-activated protein kinase kinase 7	Homo sapiens	51-54
10102631-5	1999	Addition of phorbol 12-myristate 13-acetate to these dissociated cells formed a tight junction-like structure where ZO-1 and l-afadin, but not neurabin-II or E-cadherin, accumulated.	Tetradecanoylphorbol Acetate	12-43	tight junction protein 1	Canis lupus familiaris	116-120
10102631-5	1999	Addition of phorbol 12-myristate 13-acetate to these dissociated cells formed a tight junction-like structure where ZO-1 and l-afadin, but not neurabin-II or E-cadherin, accumulated.	Tetradecanoylphorbol Acetate	12-43	afadin, adherens junction formation factor	Canis lupus familiaris	127-133
9933633-5	1999	Here we show that extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38-mitogen-activated protein kinase (MAPK) pathways control the transcription and synthesis of TNF-alpha in A3.01 T cells that produce the cytokine upon T cell activation by costimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) and ionomycin.	Tetradecanoylphorbol Acetate	330-333	tumor necrosis factor	Homo sapiens	194-203
9933633-5	1999	Here we show that extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38-mitogen-activated protein kinase (MAPK) pathways control the transcription and synthesis of TNF-alpha in A3.01 T cells that produce the cytokine upon T cell activation by costimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) and ionomycin.	Tetradecanoylphorbol Acetate	292-328	mitogen-activated protein kinase 1	Homo sapiens	18-55
9933633-7	1999	Furthermore, blockage of all three pathways almost abolishes TPA/ionomycin-induced transcriptional activation of the TNF-alpha promoter.	Tetradecanoylphorbol Acetate	61-64	tumor necrosis factor	Homo sapiens	117-126
9933633-5	1999	Here we show that extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38-mitogen-activated protein kinase (MAPK) pathways control the transcription and synthesis of TNF-alpha in A3.01 T cells that produce the cytokine upon T cell activation by costimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) and ionomycin.	Tetradecanoylphorbol Acetate	292-328	tumor necrosis factor	Homo sapiens	194-203
9933633-5	1999	Here we show that extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38-mitogen-activated protein kinase (MAPK) pathways control the transcription and synthesis of TNF-alpha in A3.01 T cells that produce the cytokine upon T cell activation by costimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) and ionomycin.	Tetradecanoylphorbol Acetate	330-333	mitogen-activated protein kinase 1	Homo sapiens	18-55
9933633-8	1999	Selective inhibition of one or more MAPK pathways impairs TNF-alpha induction by TPA/ionomycin, indicating a cooperation between these signal transduction pathways.	Tetradecanoylphorbol Acetate	81-84	mitogen-activated protein kinase 14	Homo sapiens	36-40
9933633-8	1999	Selective inhibition of one or more MAPK pathways impairs TNF-alpha induction by TPA/ionomycin, indicating a cooperation between these signal transduction pathways.	Tetradecanoylphorbol Acetate	81-84	tumor necrosis factor	Homo sapiens	58-67
9973532-8	1999	Cross-linking the intact monomorphic HLA-A,B,C epitope or the polymorphic HLA-B7 epitope induced IL-2 production upon costimulation with PMA.	Tetradecanoylphorbol Acetate	137-140	major histocompatibility complex, class I, A	Homo sapiens	37-44
9920928-2	1999	The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation.	Tetradecanoylphorbol Acetate	67-98	interleukin 1 beta	Homo sapiens	134-142
9920928-2	1999	The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation.	Tetradecanoylphorbol Acetate	100-103	interleukin 1 beta	Homo sapiens	134-142
9895308-11	1999	By contrast, PMA markedly stabilized p21(WAF1) mRNA; the half-life (t1/2) of p21(WAF1) in PMA-treated cells was &gt;8 h compared with &lt;1 h in untreated cells.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	37-40
9895308-11	1999	By contrast, PMA markedly stabilized p21(WAF1) mRNA; the half-life (t1/2) of p21(WAF1) in PMA-treated cells was &gt;8 h compared with &lt;1 h in untreated cells.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	41-45
9895308-11	1999	By contrast, PMA markedly stabilized p21(WAF1) mRNA; the half-life (t1/2) of p21(WAF1) in PMA-treated cells was &gt;8 h compared with &lt;1 h in untreated cells.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	77-80
9895308-11	1999	By contrast, PMA markedly stabilized p21(WAF1) mRNA; the half-life (t1/2) of p21(WAF1) in PMA-treated cells was &gt;8 h compared with &lt;1 h in untreated cells.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	81-85
9931015-6	1999	Activation of protein kinase C by TPA or increases in [Ca2+]i by the calcium ionophore A23187 stimulated p130(Cas) phosphorylation.	Tetradecanoylphorbol Acetate	34-37	phospholipase C-like 1	Rattus norvegicus	105-109
9950771-14	1999	However, activation of PKC by phorbol 12-myristate 13-acetate (PMA) dramatically increased cellular resistance to the apoptotic effect of TNF-alpha.	Tetradecanoylphorbol Acetate	30-61	tumor necrosis factor	Rattus norvegicus	138-147
9950771-14	1999	However, activation of PKC by phorbol 12-myristate 13-acetate (PMA) dramatically increased cellular resistance to the apoptotic effect of TNF-alpha.	Tetradecanoylphorbol Acetate	63-66	tumor necrosis factor	Rattus norvegicus	138-147
9890556-7	1999	Stimulation of THP-1 cells with LPS + phorbol myristate acetate increased the percentage of cells expressing pro-TNFalpha by 10-fold.	Tetradecanoylphorbol Acetate	38-63	GLI family zinc finger 2	Homo sapiens	15-20
9890556-7	1999	Stimulation of THP-1 cells with LPS + phorbol myristate acetate increased the percentage of cells expressing pro-TNFalpha by 10-fold.	Tetradecanoylphorbol Acetate	38-63	tumor necrosis factor	Homo sapiens	113-121
9973532-8	1999	Cross-linking the intact monomorphic HLA-A,B,C epitope or the polymorphic HLA-B7 epitope induced IL-2 production upon costimulation with PMA.	Tetradecanoylphorbol Acetate	137-140	interleukin 2	Homo sapiens	97-101
9885283-7	1999	ATP stimulation triggered release of the pro-inflammatory cytokine IL-6 in fibroblasts pre-treated with PMA and bacterial endotoxin.	Tetradecanoylphorbol Acetate	104-107	interleukin 6	Homo sapiens	67-71
10426567-0	1999	Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway.	Tetradecanoylphorbol Acetate	260-291	insulin	Homo sapiens	101-108
10426567-0	1999	Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway.	Tetradecanoylphorbol Acetate	293-296	insulin	Homo sapiens	101-108
9925748-6	1999	12-O-Tetradecanoylphorbol 13-acetate (TPA), a protein kinase C (PKC)-activating phorbol ester, induced an accumulation of HSP27 (EC50, 20 nmol/L) and alphaB-crystallin (EC50, 2 nmol/L).	Tetradecanoylphorbol Acetate	0-36	proline rich transmembrane protein 2	Homo sapiens	46-62
9925748-6	1999	12-O-Tetradecanoylphorbol 13-acetate (TPA), a protein kinase C (PKC)-activating phorbol ester, induced an accumulation of HSP27 (EC50, 20 nmol/L) and alphaB-crystallin (EC50, 2 nmol/L).	Tetradecanoylphorbol Acetate	0-36	proline rich transmembrane protein 2	Homo sapiens	64-67
9925748-6	1999	12-O-Tetradecanoylphorbol 13-acetate (TPA), a protein kinase C (PKC)-activating phorbol ester, induced an accumulation of HSP27 (EC50, 20 nmol/L) and alphaB-crystallin (EC50, 2 nmol/L).	Tetradecanoylphorbol Acetate	38-41	proline rich transmembrane protein 2	Homo sapiens	46-62
9925748-6	1999	12-O-Tetradecanoylphorbol 13-acetate (TPA), a protein kinase C (PKC)-activating phorbol ester, induced an accumulation of HSP27 (EC50, 20 nmol/L) and alphaB-crystallin (EC50, 2 nmol/L).	Tetradecanoylphorbol Acetate	38-41	proline rich transmembrane protein 2	Homo sapiens	64-67
9925748-8	1999	Staurosporine and calphostin C, inhibitors of PKC, significantly reduced the vasopressin-induced accumulation of HSP27 and alphaB-crystallin as well as that induced by TPA.	Tetradecanoylphorbol Acetate	168-171	proline rich transmembrane protein 2	Homo sapiens	46-49
9925748-8	1999	Staurosporine and calphostin C, inhibitors of PKC, significantly reduced the vasopressin-induced accumulation of HSP27 and alphaB-crystallin as well as that induced by TPA.	Tetradecanoylphorbol Acetate	168-171	arginine vasopressin	Homo sapiens	77-88
9925750-6	1999	The ability of phorbol myristate acetate to preferentially diminish protein kinase Calpha-protein localization to the nucleus by 24 h and thereby block differentiation induced by hexamethylene bisacetamide was paralleled by the ability of protein kinase Calpha antisense transfection to block differentiation.	Tetradecanoylphorbol Acetate	15-40	protein kinase C alpha	Homo sapiens	68-89
9925750-6	1999	The ability of phorbol myristate acetate to preferentially diminish protein kinase Calpha-protein localization to the nucleus by 24 h and thereby block differentiation induced by hexamethylene bisacetamide was paralleled by the ability of protein kinase Calpha antisense transfection to block differentiation.	Tetradecanoylphorbol Acetate	15-40	protein kinase C alpha	Homo sapiens	239-260
10037239-2	1999	The production of interleukin 2 (IL2), interferon gamma (IFNgamma) and tumor necrosis factor alpha (TNFalpha) was determined in T-helper (Th) and cytotoxic T-cells (CTL) as well as in naive and memory cells after stimulation with phorbol-12-myristate-13-acetate (PMA) and ionomycin under the influence of monensin.	Tetradecanoylphorbol Acetate	263-266	tumor necrosis factor	Homo sapiens	100-108
10078938-2	1999	While barely detectable in normal epidermis, 8-LOX was transiently induced by 12-O-tetradecanoylphorbol-13-acetate and constitutively expressed in papillomas but not carcinomas obtained by the initiation-promotion protocol of mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	78-114	arachidonate 8-lipoxygenase	Mus musculus	45-50
9925763-4	1999	We tested whether the activities of the mitogen-activated protein kinases (ERK1/2 and JNK1) varied in response to EGF, TPA, or combinations of these agonists and if the same treatments altered patterns of immediate early gene expression.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 3	Homo sapiens	75-81
9925763-4	1999	We tested whether the activities of the mitogen-activated protein kinases (ERK1/2 and JNK1) varied in response to EGF, TPA, or combinations of these agonists and if the same treatments altered patterns of immediate early gene expression.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 8	Homo sapiens	86-90
10037239-2	1999	The production of interleukin 2 (IL2), interferon gamma (IFNgamma) and tumor necrosis factor alpha (TNFalpha) was determined in T-helper (Th) and cytotoxic T-cells (CTL) as well as in naive and memory cells after stimulation with phorbol-12-myristate-13-acetate (PMA) and ionomycin under the influence of monensin.	Tetradecanoylphorbol Acetate	230-261	tumor necrosis factor	Homo sapiens	100-108
10202851-6	1999	NTE-122 also enhanced HDL-induced cholesterol efflux from established foam cells converted from PMA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	96-99	patatin like phospholipase domain containing 6	Homo sapiens	0-3
9891065-8	1999	TPA-induced activation of the SRE was partially inhibited by dominant negative c-Raf, ERK1, or ERK2, and constitutively active mutants of PKC-alpha and PKC-epsilon activated the transactivation domain of Elk-1.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Mus musculus	95-99
9891065-8	1999	TPA-induced activation of the SRE was partially inhibited by dominant negative c-Raf, ERK1, or ERK2, and constitutively active mutants of PKC-alpha and PKC-epsilon activated the transactivation domain of Elk-1.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Mus musculus	138-147
9891065-10	1999	Furthermore, TPA treatment of serum-starved NIH 3T3 cells led to phosphorylation of SEK1, and constitutively active mutants of PKC-alpha and PKC-epsilon activated the transactivation domain of c-Jun, a major substrate of JNK.	Tetradecanoylphorbol Acetate	13-16	protein kinase C, alpha	Mus musculus	127-136
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	interleukin 2	Homo sapiens	163-167
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	interleukin 4	Homo sapiens	169-173
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	interferon gamma	Homo sapiens	181-190
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	tumor necrosis factor	Homo sapiens	195-204
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	interleukin 6	Homo sapiens	242-246
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	248-252
9882624-5	1999	The inhibition of IL-2 production was observed in the CD3(+) T-lymphocyte cytoplasm as early as 4 h after activation by PMA+ionomycin.	Tetradecanoylphorbol Acetate	120-123	interleukin 2	Homo sapiens	18-22
9935190-9	1999	TPA treatment causes rapid translocation of PKC-alpha to the insoluble fraction.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	44-53
10195695-4	1999	Likewise, topical treatment of mouse skin with PMA results in increased PPARbeta mRNA expression in the epidermis.	Tetradecanoylphorbol Acetate	47-50	peroxisome proliferator activator receptor delta	Mus musculus	72-80
9891015-7	1999	Furthermore, specific activation of ERK1,2 pathway by 12-O-tetradecanoylphorbol-13-acetate markedly suppressed MMP-13 expression in dermal fibroblasts in collagen gel.	Tetradecanoylphorbol Acetate	54-90	mitogen-activated protein kinase 3	Homo sapiens	36-42
9891015-7	1999	Furthermore, specific activation of ERK1,2 pathway by 12-O-tetradecanoylphorbol-13-acetate markedly suppressed MMP-13 expression in dermal fibroblasts in collagen gel.	Tetradecanoylphorbol Acetate	54-90	matrix metallopeptidase 13	Homo sapiens	111-117
9880563-2	1999	The MCL1 member of the BCL2 family is up-regulated during the induction of monocytic differentiation (approximately 10-fold with 12-O-tetradecanoylphorbol 13-acetate (TPA)).	Tetradecanoylphorbol Acetate	129-165	BCL2 apoptosis regulator	Homo sapiens	23-27
9880563-2	1999	The MCL1 member of the BCL2 family is up-regulated during the induction of monocytic differentiation (approximately 10-fold with 12-O-tetradecanoylphorbol 13-acetate (TPA)).	Tetradecanoylphorbol Acetate	167-170	BCL2 apoptosis regulator	Homo sapiens	23-27
9880563-7	1999	Thus, the mechanism of the TPA-induced increase in MCL1 expression seen in myelomonocytic cells at early stages of differentiation involves signal transduction through ERKs and transcriptional activation through SRF/Elk-1.	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase 1	Homo sapiens	168-172
9935229-4	1999	In short-term tissue-culture experiments of colonic mucosal biopsies, we found reduced S-phase labeling in the 2 apical compartments of longitudinally sectioned crypts when PKC was activated by 200 nM of the phorbol ester TPA (n = 8).	Tetradecanoylphorbol Acetate	222-225	proline rich transmembrane protein 2	Homo sapiens	173-176
9920756-4	1999	HL-60 cell differentiation was completely arrested in TPA treated cells that expressed WT1 or its zinc-finger domain alone whereas TPA fully induced macrophage differentiation in control HL-60 cells, indicating that high level expression of WT1 is capable of differentiation arrest of myeloid cells and that its effect may be mediated through its zinc-finger domain.	Tetradecanoylphorbol Acetate	54-57	WT1 transcription factor	Homo sapiens	87-90
9920756-4	1999	HL-60 cell differentiation was completely arrested in TPA treated cells that expressed WT1 or its zinc-finger domain alone whereas TPA fully induced macrophage differentiation in control HL-60 cells, indicating that high level expression of WT1 is capable of differentiation arrest of myeloid cells and that its effect may be mediated through its zinc-finger domain.	Tetradecanoylphorbol Acetate	54-57	WT1 transcription factor	Homo sapiens	241-244
9920756-4	1999	HL-60 cell differentiation was completely arrested in TPA treated cells that expressed WT1 or its zinc-finger domain alone whereas TPA fully induced macrophage differentiation in control HL-60 cells, indicating that high level expression of WT1 is capable of differentiation arrest of myeloid cells and that its effect may be mediated through its zinc-finger domain.	Tetradecanoylphorbol Acetate	131-134	WT1 transcription factor	Homo sapiens	241-244
9873009-2	1999	In this study, we show that the secretion of matrix metalloproteinase-9 (MMP-9) from HT 1080 human fibrosarcoma cells was stimulated by phorbol 12-myristate 13-acetate in a time- and dose-dependent manner that involved protein kinase C. The phorbol ester also increased PLD activity in the cells.	Tetradecanoylphorbol Acetate	136-167	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	270-273
9927206-3	1999	Pretreatment of murine NIH3T3 and human 293 cells with 5 microM taxol resulted in complete inhibition of phorbol, 12-myristate, 13-acetate (PMA) mediated NF-kappaB activation, detected as the loss of DNA binding and reduced NF-kappaB dependent reporter gene activity.	Tetradecanoylphorbol Acetate	140-143	nuclear factor kappa B subunit 1	Homo sapiens	154-163
9927206-3	1999	Pretreatment of murine NIH3T3 and human 293 cells with 5 microM taxol resulted in complete inhibition of phorbol, 12-myristate, 13-acetate (PMA) mediated NF-kappaB activation, detected as the loss of DNA binding and reduced NF-kappaB dependent reporter gene activity.	Tetradecanoylphorbol Acetate	140-143	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	224-233
9927206-8	1999	Both PMA and nocodazole, a MT depolymerizing agent, caused microtubule depolymerization, whereas TNF-alpha did not alter MT integrity; concomitant taxol treatment blocked both nocodazole and PMA induced depolymerization of MTs, as well as NF-kappaB induction, thus demonstrating a link between microtubule depolymerization and NF-kappaB activation.	Tetradecanoylphorbol Acetate	5-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	239-248
9927206-8	1999	Both PMA and nocodazole, a MT depolymerizing agent, caused microtubule depolymerization, whereas TNF-alpha did not alter MT integrity; concomitant taxol treatment blocked both nocodazole and PMA induced depolymerization of MTs, as well as NF-kappaB induction, thus demonstrating a link between microtubule depolymerization and NF-kappaB activation.	Tetradecanoylphorbol Acetate	5-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	327-336
9870925-10	1999	Although the surface expression of TNF-R assessed by 125I-TNF specific binding was decreased in the presence of hydrogen peroxide or PMA, TNF-RI mRNA transcript levels remained unchanged.	Tetradecanoylphorbol Acetate	133-136	tumor necrosis factor	Homo sapiens	35-38
9989263-3	1999	Upon treatment with phorbol myristate acetate (PMA), PKC alpha translocated from the cytosolic fraction to the membrane fraction to which PLD1 also localized.	Tetradecanoylphorbol Acetate	20-45	phospholipase D1	Rattus norvegicus	138-142
9989263-3	1999	Upon treatment with phorbol myristate acetate (PMA), PKC alpha translocated from the cytosolic fraction to the membrane fraction to which PLD1 also localized.	Tetradecanoylphorbol Acetate	47-50	phospholipase D1	Rattus norvegicus	138-142
10453985-4	1999	On the other hand, sphingosine at concentrations of 100-250 microM strongly stimulated PLD activity as compared to the effect of phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), known as a PLD activator.	Tetradecanoylphorbol Acetate	144-180	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	199-202
10453985-5	1999	The effect of TPA on PLD is linked to the activation of protein kinase C. The present study also shows that sphingosine additively enhances TPA-mediated PLD activity.	Tetradecanoylphorbol Acetate	14-17	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	21-24
10453985-5	1999	The effect of TPA on PLD is linked to the activation of protein kinase C. The present study also shows that sphingosine additively enhances TPA-mediated PLD activity.	Tetradecanoylphorbol Acetate	14-17	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	153-156
10453985-5	1999	The effect of TPA on PLD is linked to the activation of protein kinase C. The present study also shows that sphingosine additively enhances TPA-mediated PLD activity.	Tetradecanoylphorbol Acetate	140-143	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	21-24
10453985-5	1999	The effect of TPA on PLD is linked to the activation of protein kinase C. The present study also shows that sphingosine additively enhances TPA-mediated PLD activity.	Tetradecanoylphorbol Acetate	140-143	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	153-156
9886915-3	1999	In other experiments, PKC was activated using phorbol 12-myristate 13-acetate, and Ca2+ influx was increased by means of a Ca2+ ionophore.	Tetradecanoylphorbol Acetate	46-77	proline rich transmembrane protein 2	Homo sapiens	22-25
10370867-9	1999	As judged by the reverse transcriptase-polymerase chain reaction, resveratrol selectively inhibited TPA-induced expression of c-fos and transforming growth factor-beta 1 (TGF-beta 1), but did not affect other TPA-induced gene products including COX-1, COX-2, c-myc, c-jun, and tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	100-103	cytochrome c oxidase I, mitochondrial	Mus musculus	245-250
10668496-2	1999	In this study, we investigated whether resveratrol, a chemopreventive agent found in grapes, could suppress phorbol ester (PMA)-mediated induction of COX-2 in human mammary and oral epithelial cells.	Tetradecanoylphorbol Acetate	123-126	prostaglandin-endoperoxide synthase 2	Homo sapiens	150-155
10668496-5	1999	Nuclear runoffs revealed increased rates of COX-2 transcription after treatment with PMA, an effect that was inhibited by resveratrol.	Tetradecanoylphorbol Acetate	85-88	prostaglandin-endoperoxide synthase 2	Homo sapiens	44-49
9858479-8	1999	Phorbol 12-myristate 13-acetate also significantly stimulated the activity of gelatinases A and B and TIMP-1 in conditioned medium and of TIMP-3 in ECM (p &lt; 0.05).	Tetradecanoylphorbol Acetate	0-31	TIMP metallopeptidase inhibitor 1	Equus caballus	102-108
9884362-2	1999	PMA and ionomycin were shown to induce IL-2 production in swine blood.	Tetradecanoylphorbol Acetate	0-3	IL2	Sus scrofa	39-43
9884362-3	1999	The IC50 of FK506 in inhibiting IL-2 production in whole blood and isolated PBMC stimulated with PMA and ionomycin measured 1.2 and 0.04 nM, respectively.	Tetradecanoylphorbol Acetate	97-100	IL2	Sus scrofa	32-36
10221154-6	1999	The amount of AOS produced by the neutrophils adherent to fibronectin or polystyrene was maintained for one hour after stimulation with PMA, whereas that by suspended neutrophils gradually decreased with the time after stimulation.	Tetradecanoylphorbol Acetate	136-139	fibronectin 1	Homo sapiens	58-69
9874668-5	1999	Upon activation with phorbol 12-myristate 13-acetate (PMA), the numbers of T cells synthesizing IL-2 were similar for all study groups.	Tetradecanoylphorbol Acetate	21-52	interleukin 2	Homo sapiens	96-100
9874668-5	1999	Upon activation with phorbol 12-myristate 13-acetate (PMA), the numbers of T cells synthesizing IL-2 were similar for all study groups.	Tetradecanoylphorbol Acetate	54-57	interleukin 2	Homo sapiens	96-100
10370867-9	1999	As judged by the reverse transcriptase-polymerase chain reaction, resveratrol selectively inhibited TPA-induced expression of c-fos and transforming growth factor-beta 1 (TGF-beta 1), but did not affect other TPA-induced gene products including COX-1, COX-2, c-myc, c-jun, and tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	100-103	tumor necrosis factor	Mus musculus	277-304
9914472-6	1999	HDL3 (370 nmol.mL-1 cholesterol-HDL) was incubated with PMNs (2 x 106. mL-1) in NaCl/Pi in the presence or absence of an iron chelate complex (10 microm Fe-nitrilotriacetic acid) at 37 degreesC for 60 min or 24 h. Phorbol myristate acetate (PMA) or formyl-methionylleucyphenylalanine (fMetLeuPhe) was used to stimulate PMNs.	Tetradecanoylphorbol Acetate	214-239	HDL3	Homo sapiens	0-4
9886832-9	1999	Unlike CRF, the expression of CRF-BP message and peptide was increased by phorbol 12-myristate 13-acetate or dexamethasone.	Tetradecanoylphorbol Acetate	74-105	corticotropin releasing hormone binding protein	Homo sapiens	30-36
9914472-6	1999	HDL3 (370 nmol.mL-1 cholesterol-HDL) was incubated with PMNs (2 x 106. mL-1) in NaCl/Pi in the presence or absence of an iron chelate complex (10 microm Fe-nitrilotriacetic acid) at 37 degreesC for 60 min or 24 h. Phorbol myristate acetate (PMA) or formyl-methionylleucyphenylalanine (fMetLeuPhe) was used to stimulate PMNs.	Tetradecanoylphorbol Acetate	241-244	HDL3	Homo sapiens	0-4
9869604-8	1999	Long-term exposure of cells to phorbol myristate acetate caused the depletion of PKC-delta and -gamma and prevented also IGF-I-induced cell motility.	Tetradecanoylphorbol Acetate	31-56	insulin like growth factor 1	Homo sapiens	121-126
9931126-3	1999	THP1, a human monocytic leukemia cell line, was differentiated to macrophages by adding of phorbol 12-myristate 13-acetate for 24 hours.	Tetradecanoylphorbol Acetate	91-122	GLI family zinc finger 2	Homo sapiens	0-4
10659591-5	1999	Direct activation of PKC by a specific PKC activator, phorbol myristate acetate (PMA), induced a remarkable O2- generation and a small MPO release, indicating that PKC may regulate entirely O2- synthesis and partially MPO degranulation.	Tetradecanoylphorbol Acetate	54-79	myeloperoxidase	Homo sapiens	135-138
9886369-1	1999	In this study, we demonstrate that human NK cells, human NK clones, the human NK cell line (NK3.3), and a population of murine NK cells can produce the type 2 cytokine IL-13 in response to IL-2 or phorbol myristate acetate plus ionomycin.	Tetradecanoylphorbol Acetate	197-222	interleukin 13	Mus musculus	168-173
9886369-3	1999	Six of 12 human NK clones tested produced IL-13 protein in response to IL-2 or phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	79-104	interleukin 13	Homo sapiens	42-47
10474016-3	1999	In Western blot analysis, polyclonal anti-CBG antibodies recognized a protein of approximately 55 kD in the protein extracts prepared from 3A (tPA-30-1) cells.	Tetradecanoylphorbol Acetate	143-146	serpin family A member 6	Homo sapiens	42-45
10102760-8	1999	In contrast, melatonin at a final concentration of 10 pg/mL, added to whole blood incubated with LPS and also the phorbol ester, PMA, caused a significant rise of 25%; whereas 100 pg/mL enhanced LPS + PMA-induced TNF by approximately 80% as compared to LPS + PMA alone.	Tetradecanoylphorbol Acetate	129-132	tumor necrosis factor	Homo sapiens	213-216
12840904-0	1999	TPA enhances growth hormone (GH) secretion effect of GH-releasing hormone (GHRH) by human gsp-positive pituitary somatotrophinomas.	Tetradecanoylphorbol Acetate	0-3	growth hormone 1	Homo sapiens	13-27
12840904-0	1999	TPA enhances growth hormone (GH) secretion effect of GH-releasing hormone (GHRH) by human gsp-positive pituitary somatotrophinomas.	Tetradecanoylphorbol Acetate	0-3	growth hormone 1	Homo sapiens	29-31
12840904-0	1999	TPA enhances growth hormone (GH) secretion effect of GH-releasing hormone (GHRH) by human gsp-positive pituitary somatotrophinomas.	Tetradecanoylphorbol Acetate	0-3	growth hormone releasing hormone	Homo sapiens	53-73
12840904-0	1999	TPA enhances growth hormone (GH) secretion effect of GH-releasing hormone (GHRH) by human gsp-positive pituitary somatotrophinomas.	Tetradecanoylphorbol Acetate	0-3	growth hormone releasing hormone	Homo sapiens	75-79
12840904-0	1999	TPA enhances growth hormone (GH) secretion effect of GH-releasing hormone (GHRH) by human gsp-positive pituitary somatotrophinomas.	Tetradecanoylphorbol Acetate	0-3	GNAS complex locus	Homo sapiens	90-93
12840904-5	1999	Moreover, phorbol ester, 1, 2-tetradecanoylphorbol-13-acetate (TPA), enhanced stimulation of lated the GH secretion effect exerted by GHRH in gsp-positive somatotrophinomas, whereas this effect was not observed in gsp-negative tumors.	Tetradecanoylphorbol Acetate	63-66	growth hormone 1	Homo sapiens	103-105
12840904-5	1999	Moreover, phorbol ester, 1, 2-tetradecanoylphorbol-13-acetate (TPA), enhanced stimulation of lated the GH secretion effect exerted by GHRH in gsp-positive somatotrophinomas, whereas this effect was not observed in gsp-negative tumors.	Tetradecanoylphorbol Acetate	63-66	growth hormone releasing hormone	Homo sapiens	134-138
12840904-5	1999	Moreover, phorbol ester, 1, 2-tetradecanoylphorbol-13-acetate (TPA), enhanced stimulation of lated the GH secretion effect exerted by GHRH in gsp-positive somatotrophinomas, whereas this effect was not observed in gsp-negative tumors.	Tetradecanoylphorbol Acetate	63-66	GNAS complex locus	Homo sapiens	142-145
12840904-5	1999	Moreover, phorbol ester, 1, 2-tetradecanoylphorbol-13-acetate (TPA), enhanced stimulation of lated the GH secretion effect exerted by GHRH in gsp-positive somatotrophinomas, whereas this effect was not observed in gsp-negative tumors.	Tetradecanoylphorbol Acetate	63-66	GNAS complex locus	Homo sapiens	214-217
10659591-5	1999	Direct activation of PKC by a specific PKC activator, phorbol myristate acetate (PMA), induced a remarkable O2- generation and a small MPO release, indicating that PKC may regulate entirely O2- synthesis and partially MPO degranulation.	Tetradecanoylphorbol Acetate	54-79	myeloperoxidase	Homo sapiens	218-221
10659591-5	1999	Direct activation of PKC by a specific PKC activator, phorbol myristate acetate (PMA), induced a remarkable O2- generation and a small MPO release, indicating that PKC may regulate entirely O2- synthesis and partially MPO degranulation.	Tetradecanoylphorbol Acetate	81-84	myeloperoxidase	Homo sapiens	135-138
10659591-5	1999	Direct activation of PKC by a specific PKC activator, phorbol myristate acetate (PMA), induced a remarkable O2- generation and a small MPO release, indicating that PKC may regulate entirely O2- synthesis and partially MPO degranulation.	Tetradecanoylphorbol Acetate	81-84	myeloperoxidase	Homo sapiens	218-221
10656176-3	1999	Pretreatment of MRC-5 and phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells with IFN-alpha or IFN-gamma for 24 hr prior to the infection reduced the number of infected cells and virus yield.	Tetradecanoylphorbol Acetate	26-57	interferon alpha 1	Homo sapiens	89-98
10704080-3	1999	We measured the effect of CsA on basal and phorbol-myristate-acetate (PMA)-stimulated production of interleukin-6 using the human monocyte cell line U937 differentiated with dimethylsulfoxide (DMSO).	Tetradecanoylphorbol Acetate	43-68	interleukin 6	Homo sapiens	100-113
10704080-3	1999	We measured the effect of CsA on basal and phorbol-myristate-acetate (PMA)-stimulated production of interleukin-6 using the human monocyte cell line U937 differentiated with dimethylsulfoxide (DMSO).	Tetradecanoylphorbol Acetate	70-73	interleukin 6	Homo sapiens	100-113
10656176-3	1999	Pretreatment of MRC-5 and phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells with IFN-alpha or IFN-gamma for 24 hr prior to the infection reduced the number of infected cells and virus yield.	Tetradecanoylphorbol Acetate	26-57	interferon gamma	Homo sapiens	102-111
10656176-3	1999	Pretreatment of MRC-5 and phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells with IFN-alpha or IFN-gamma for 24 hr prior to the infection reduced the number of infected cells and virus yield.	Tetradecanoylphorbol Acetate	59-62	interferon alpha 1	Homo sapiens	89-98
9858570-7	1999	The functional role of MEKK-1 in TPA-induced SAPK activity was further supported by the demonstration that the expression of a dominant negative MEKK-1 mutant abrogated this response.	Tetradecanoylphorbol Acetate	33-36	mitogen-activated protein kinase 9	Homo sapiens	45-49
9858570-2	1999	The present studies demonstrated that treatment of U-937 and HL-60 myeloid leukemia cells with TPA, phorbol-12,13-dibutyrate, or bryostatin 1 was associated with the induction of stress-activated protein kinase (SAPK).	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 9	Homo sapiens	179-210
10656176-3	1999	Pretreatment of MRC-5 and phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells with IFN-alpha or IFN-gamma for 24 hr prior to the infection reduced the number of infected cells and virus yield.	Tetradecanoylphorbol Acetate	59-62	interferon gamma	Homo sapiens	102-111
9858570-2	1999	The present studies demonstrated that treatment of U-937 and HL-60 myeloid leukemia cells with TPA, phorbol-12,13-dibutyrate, or bryostatin 1 was associated with the induction of stress-activated protein kinase (SAPK).	Tetradecanoylphorbol Acetate	95-98	mitogen-activated protein kinase 9	Homo sapiens	212-216
9858570-4	1999	A direct role for PKCbeta in TPA-induced SAPK activity in TUR and HL-525 cells that stably express PKCbeta was confirmed.	Tetradecanoylphorbol Acetate	29-32	mitogen-activated protein kinase 9	Homo sapiens	41-45
9858570-8	1999	These findings indicate that PKCbeta activation is necessary for activation of the MEKK-1--&gt;SEK1--&gt;SAPK cascade in the TPA response of myeloid leukemia cells.	Tetradecanoylphorbol Acetate	125-128	mitogen-activated protein kinase kinase 4	Homo sapiens	95-99
9858570-8	1999	These findings indicate that PKCbeta activation is necessary for activation of the MEKK-1--&gt;SEK1--&gt;SAPK cascade in the TPA response of myeloid leukemia cells.	Tetradecanoylphorbol Acetate	125-128	mitogen-activated protein kinase 9	Homo sapiens	105-109
9819353-7	1998	(4) VEGF was effective in preventing PMA-induced tube-like structure regression after PMA-withdrawal by (5) activating the mitogen activated protein kinase (MAPK), rather than the Akt/PKB, signaling pathway.	Tetradecanoylphorbol Acetate	37-40	vascular endothelial growth factor A	Homo sapiens	4-8
9892016-3	1999	By transient transfection of the GH3 cell line, we demonstrate that activation of the PKC system with the phorbol ester, phorbol 12-myristate 13-acetate (PMA), increases activity of region -207/+5 of the rat LHbeta gene promoter (approximately 2-fold) and markedly augments SF-1-induced stimulation (95-fold in the presence of both factors vs. 13-fold for SF-1 alone).	Tetradecanoylphorbol Acetate	121-152	luteinizing hormone subunit beta	Rattus norvegicus	208-214
9892016-8	1999	We conclude that PMA-induced stimulation of LHbeta gene expression is achieved, at least in part, by induction of Egr-1 expression.	Tetradecanoylphorbol Acetate	17-20	luteinizing hormone subunit beta	Rattus norvegicus	44-50
9892016-8	1999	We conclude that PMA-induced stimulation of LHbeta gene expression is achieved, at least in part, by induction of Egr-1 expression.	Tetradecanoylphorbol Acetate	17-20	early growth response 1	Rattus norvegicus	114-119
9858570-5	1999	We showed that TPA induced the association of PKCbeta with MEK kinase 1 (MEKK-1), an upstream effector of the SAPK/ERK kinase 1 (SEK1)--&gt;SAPK cascade.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase kinase 4	Homo sapiens	110-127
9858570-5	1999	We showed that TPA induced the association of PKCbeta with MEK kinase 1 (MEKK-1), an upstream effector of the SAPK/ERK kinase 1 (SEK1)--&gt;SAPK cascade.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase kinase 4	Homo sapiens	129-133
9858570-5	1999	We showed that TPA induced the association of PKCbeta with MEK kinase 1 (MEKK-1), an upstream effector of the SAPK/ERK kinase 1 (SEK1)--&gt;SAPK cascade.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 9	Homo sapiens	110-114
9882706-3	1999	The lipid-induced ERK1/2 activation was partially inhibited by treatment of the cells with either phorbol 12-myristate 13-acetate (a long-term treatment to desensitize protein kinase C) or pertussis toxin (PTX) and was completely inhibited by a simultaneous treatment with both agents.	Tetradecanoylphorbol Acetate	98-129	mitogen-activated protein kinase 3	Homo sapiens	18-24
10851292-4	1999	In addition, prolactin and TPA increased protein kinase C (PKC) activity in prostate cells 20% to 60% and 40% to 210%, respectively.	Tetradecanoylphorbol Acetate	27-30	proline rich transmembrane protein 2	Homo sapiens	41-57
10851292-4	1999	In addition, prolactin and TPA increased protein kinase C (PKC) activity in prostate cells 20% to 60% and 40% to 210%, respectively.	Tetradecanoylphorbol Acetate	27-30	proline rich transmembrane protein 2	Homo sapiens	59-62
10851292-5	1999	The effects of both prolactin and TPA on mAAT mRNA were eliminated by downregulation of PKC.	Tetradecanoylphorbol Acetate	34-37	proline rich transmembrane protein 2	Homo sapiens	88-91
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Tetradecanoylphorbol Acetate	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Tetradecanoylphorbol Acetate	89-92	interleukin 1 beta	Homo sapiens	62-70
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Tetradecanoylphorbol Acetate	89-92	tumor necrosis factor	Homo sapiens	76-85
9894155-0	1998	Regulation of fibronectin gene expression by cyclic AMP and phorbol myristate acetate in HT-1080 human fibrosarcoma cells.	Tetradecanoylphorbol Acetate	60-85	fibronectin 1	Homo sapiens	14-25
9894155-1	1998	We studied the regulation of fibronectin (FN) gene expression by cAMP and phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells.	Tetradecanoylphorbol Acetate	74-105	fibronectin 1	Homo sapiens	29-40
9894155-1	1998	We studied the regulation of fibronectin (FN) gene expression by cAMP and phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells.	Tetradecanoylphorbol Acetate	74-105	fibronectin 1	Homo sapiens	42-44
9894155-1	1998	We studied the regulation of fibronectin (FN) gene expression by cAMP and phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells.	Tetradecanoylphorbol Acetate	107-110	fibronectin 1	Homo sapiens	29-40
9894155-1	1998	We studied the regulation of fibronectin (FN) gene expression by cAMP and phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells.	Tetradecanoylphorbol Acetate	107-110	fibronectin 1	Homo sapiens	42-44
9852137-10	1998	Down-regulation of PKC by prolonged treatment with phorbol 12-myristate 13-acetate (PMA) also inhibited induction of MnSOD by anticancer drugs, indicating an important role of PKC in MnSOD signaling by these agents.	Tetradecanoylphorbol Acetate	51-82	protein kinase C alpha	Homo sapiens	19-22
9862721-5	1998	Moreover, PMA was able to induce a normal phosphorylation of the cytosolic factor p47phox and to fully activate extracellular signal-regulated kinases (Erk1/2).	Tetradecanoylphorbol Acetate	10-13	mitogen-activated protein kinase 3	Homo sapiens	152-158
9852137-10	1998	Down-regulation of PKC by prolonged treatment with phorbol 12-myristate 13-acetate (PMA) also inhibited induction of MnSOD by anticancer drugs, indicating an important role of PKC in MnSOD signaling by these agents.	Tetradecanoylphorbol Acetate	84-87	protein kinase C alpha	Homo sapiens	19-22
9852137-10	1998	Down-regulation of PKC by prolonged treatment with phorbol 12-myristate 13-acetate (PMA) also inhibited induction of MnSOD by anticancer drugs, indicating an important role of PKC in MnSOD signaling by these agents.	Tetradecanoylphorbol Acetate	84-87	protein kinase C alpha	Homo sapiens	176-179
9860837-2	1998	Na+i-dependent 45Ca2+ uptake into NCX1- or NCX3-expressing cells, but not that into NCX2-expressing cells, was significantly enhanced by phorbol 12-myristate 13-acetate (PMA) or platelet-derived growth factor-BB, which was abolished by pretreatment of cells with calphostin C or a prior long exposure to PMA.	Tetradecanoylphorbol Acetate	137-168	solute carrier family 8 member A1	Homo sapiens	34-38
9931403-4	1998	The expression levels of AIM-1 transcript were markedly reduced during differentiation into megakaryocytic cell lineage in human leukemia cells induced by 12-o-tetradecanoyl-phorbol-13-acetate (TPA), suggesting that the downregulation of AIM-1 contributes to the differentiation by repeated duplication of DNA without cytokinesis (endomitosis).	Tetradecanoylphorbol Acetate	155-192	crystallin beta-gamma domain containing 1	Homo sapiens	25-30
9931403-4	1998	The expression levels of AIM-1 transcript were markedly reduced during differentiation into megakaryocytic cell lineage in human leukemia cells induced by 12-o-tetradecanoyl-phorbol-13-acetate (TPA), suggesting that the downregulation of AIM-1 contributes to the differentiation by repeated duplication of DNA without cytokinesis (endomitosis).	Tetradecanoylphorbol Acetate	155-192	crystallin beta-gamma domain containing 1	Homo sapiens	238-243
9931403-4	1998	The expression levels of AIM-1 transcript were markedly reduced during differentiation into megakaryocytic cell lineage in human leukemia cells induced by 12-o-tetradecanoyl-phorbol-13-acetate (TPA), suggesting that the downregulation of AIM-1 contributes to the differentiation by repeated duplication of DNA without cytokinesis (endomitosis).	Tetradecanoylphorbol Acetate	194-197	crystallin beta-gamma domain containing 1	Homo sapiens	25-30
9931403-4	1998	The expression levels of AIM-1 transcript were markedly reduced during differentiation into megakaryocytic cell lineage in human leukemia cells induced by 12-o-tetradecanoyl-phorbol-13-acetate (TPA), suggesting that the downregulation of AIM-1 contributes to the differentiation by repeated duplication of DNA without cytokinesis (endomitosis).	Tetradecanoylphorbol Acetate	194-197	crystallin beta-gamma domain containing 1	Homo sapiens	238-243
10381133-3	1998	TPA treatment also elevates the expression of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), c-myc, c-fos, c-jun, transforming growth factor-beta1 (TGF-beta1) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	0-3	cytochrome c oxidase I, mitochondrial	Mus musculus	64-69
10381133-3	1998	TPA treatment also elevates the expression of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), c-myc, c-fos, c-jun, transforming growth factor-beta1 (TGF-beta1) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Mus musculus	168-195
10381133-3	1998	TPA treatment also elevates the expression of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), c-myc, c-fos, c-jun, transforming growth factor-beta1 (TGF-beta1) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Mus musculus	197-206
9860837-2	1998	Na+i-dependent 45Ca2+ uptake into NCX1- or NCX3-expressing cells, but not that into NCX2-expressing cells, was significantly enhanced by phorbol 12-myristate 13-acetate (PMA) or platelet-derived growth factor-BB, which was abolished by pretreatment of cells with calphostin C or a prior long exposure to PMA.	Tetradecanoylphorbol Acetate	137-168	solute carrier family 8 member A3	Homo sapiens	43-47
9860837-2	1998	Na+i-dependent 45Ca2+ uptake into NCX1- or NCX3-expressing cells, but not that into NCX2-expressing cells, was significantly enhanced by phorbol 12-myristate 13-acetate (PMA) or platelet-derived growth factor-BB, which was abolished by pretreatment of cells with calphostin C or a prior long exposure to PMA.	Tetradecanoylphorbol Acetate	170-173	solute carrier family 8 member A1	Homo sapiens	34-38
9860837-2	1998	Na+i-dependent 45Ca2+ uptake into NCX1- or NCX3-expressing cells, but not that into NCX2-expressing cells, was significantly enhanced by phorbol 12-myristate 13-acetate (PMA) or platelet-derived growth factor-BB, which was abolished by pretreatment of cells with calphostin C or a prior long exposure to PMA.	Tetradecanoylphorbol Acetate	170-173	solute carrier family 8 member A3	Homo sapiens	43-47
9879997-4	1998	We found up-regulation of p21WAF1 and Bax expressions, however, the expressions of p53 and Bcl-2 genes remained unchanged in TPA-treated cells.	Tetradecanoylphorbol Acetate	125-128	BCL2 associated X, apoptosis regulator	Homo sapiens	38-41
9879997-4	1998	We found up-regulation of p21WAF1 and Bax expressions, however, the expressions of p53 and Bcl-2 genes remained unchanged in TPA-treated cells.	Tetradecanoylphorbol Acetate	125-128	BCL2 apoptosis regulator	Homo sapiens	91-96
9879997-8	1998	TPA-induced apoptosis appears to be mediated through a p53-independent pathway, and the up-regulation of p21WAF1 and Bax may be the molecular mechanisms by which TPA induces apoptosis.	Tetradecanoylphorbol Acetate	0-3	tumor protein p53	Homo sapiens	55-58
9879997-8	1998	TPA-induced apoptosis appears to be mediated through a p53-independent pathway, and the up-regulation of p21WAF1 and Bax may be the molecular mechanisms by which TPA induces apoptosis.	Tetradecanoylphorbol Acetate	162-165	BCL2 associated X, apoptosis regulator	Homo sapiens	117-120
9879997-4	1998	We found up-regulation of p21WAF1 and Bax expressions, however, the expressions of p53 and Bcl-2 genes remained unchanged in TPA-treated cells.	Tetradecanoylphorbol Acetate	125-128	tumor protein p53	Homo sapiens	83-86
9837861-9	1998	The results showed that TPA induced endogenous MnSOD expression and inhibited both AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	24-27	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-87
9884090-5	1998	Treatment of cells with staurosporine and Ro 31-8220 inhibited the PMA-induced potentiation of both AA release and cyclic AMP accumulation, while Go 6976 (an inhibitor of classical PKC isoforms) and LY 379196 (a specific inhibitor of PKCbeta) inhibited the AA response but failed to affect the enhancement of the cyclic AMP response by PMA.	Tetradecanoylphorbol Acetate	67-70	protein kinase C, alpha	Mus musculus	181-184
9884090-11	1998	Pretreatment of cells with PMA for 2-24 h resulted in a time-dependent down-regulation of PKCalpha, betaI, betaII, and delta expression, while the levels of the other four PKC isozymes were unchanged after PMA treatment for 24 h. A decrease in the potentiation of AA release by PMA was observed, concomitant with the time-dependent down-regulation of PKC.	Tetradecanoylphorbol Acetate	27-30	protein kinase C, alpha	Mus musculus	90-98
9884090-11	1998	Pretreatment of cells with PMA for 2-24 h resulted in a time-dependent down-regulation of PKCalpha, betaI, betaII, and delta expression, while the levels of the other four PKC isozymes were unchanged after PMA treatment for 24 h. A decrease in the potentiation of AA release by PMA was observed, concomitant with the time-dependent down-regulation of PKC.	Tetradecanoylphorbol Acetate	27-30	protein kinase C, alpha	Mus musculus	90-93
9884090-11	1998	Pretreatment of cells with PMA for 2-24 h resulted in a time-dependent down-regulation of PKCalpha, betaI, betaII, and delta expression, while the levels of the other four PKC isozymes were unchanged after PMA treatment for 24 h. A decrease in the potentiation of AA release by PMA was observed, concomitant with the time-dependent down-regulation of PKC.	Tetradecanoylphorbol Acetate	27-30	protein kinase C, alpha	Mus musculus	172-175
9881671-9	1998	Phorbol myristate acetate induced L-plastin phosphorylation in both leukocytes and fibroblasts, lending support to the view that protein kinase C is the likely candidate kinase for L-plastin phosphorylation.	Tetradecanoylphorbol Acetate	0-25	lymphocyte cytosolic protein 1	Homo sapiens	34-43
9881671-9	1998	Phorbol myristate acetate induced L-plastin phosphorylation in both leukocytes and fibroblasts, lending support to the view that protein kinase C is the likely candidate kinase for L-plastin phosphorylation.	Tetradecanoylphorbol Acetate	0-25	lymphocyte cytosolic protein 1	Homo sapiens	181-190
9837861-9	1998	The results showed that TPA induced endogenous MnSOD expression and inhibited both AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	24-27	nuclear factor kappa B subunit 1	Homo sapiens	92-101
9862370-3	1998	Addition of various co-stimuli (phorbol 12-myristate 13-acetate or monoclonal antibodies to CD3 or CD2) increases the CD82-induced morphological alterations and, reciprocally, CD82 engagement synergizes with these stimuli to induce T cell activation as indicated by both primary tyrosine phosphorylation and IL-2 production.	Tetradecanoylphorbol Acetate	32-63	interleukin 2	Homo sapiens	308-312
9876227-2	1998	CD45RA or CD45RO CD4 T cells were cultured for 4 days with phorbol myristate acetate (PMA) and ionomycin and either IL-4, IFN-gamma or IL-12 and their ability to proliferate and secrete IFN-gamma and IL-4 determined.	Tetradecanoylphorbol Acetate	59-84	CD4 molecule	Homo sapiens	0-3
9887232-11	1998	The cytosolic PLA2 (cPLA2)/Ca2+-independent PLA2 (iPLA2) inhibitor, AACOCF3, inhibited 75.6% PMA-stimulated LPA secretion in ovarian cancer cells, suggesting a cPLA2/iPLA2 activity was involved in LPA production from ovarian cancer cells.	Tetradecanoylphorbol Acetate	93-96	phospholipase A2 group VI	Homo sapiens	14-18
9887232-11	1998	The cytosolic PLA2 (cPLA2)/Ca2+-independent PLA2 (iPLA2) inhibitor, AACOCF3, inhibited 75.6% PMA-stimulated LPA secretion in ovarian cancer cells, suggesting a cPLA2/iPLA2 activity was involved in LPA production from ovarian cancer cells.	Tetradecanoylphorbol Acetate	93-96	phospholipase A2 group VI	Homo sapiens	50-55
9826384-4	1998	At 0.1 to 10 ng/ml, TNF-alpha also increased superoxide anion (O2-) produced by PMNs in response to phorbol myristate acetate, N-formylmethionyl leucyl phenylalanine, and unopsonized hyphae (P &lt; 0.01) but did not exert any effect on PMN phagocytosis of conidia in the presence of serum.	Tetradecanoylphorbol Acetate	100-125	tumor necrosis factor	Homo sapiens	20-29
9826384-5	1998	By comparison, TNF-alpha induced only a slight increase in O2- production by MNCs in response to phorbol myristate acetate (P = 0.05) and no concomitant increase in the percentage of MNC-induced hyphal damage.	Tetradecanoylphorbol Acetate	97-122	tumor necrosis factor	Homo sapiens	15-24
9877282-2	1998	Furthermore, this effect was not LPS-specific, as TNF-alpha production was reduced by HO* radical scavengers to a similar extent upon stimulation of PBMC with immune complexes (IC), concanavalin A (Con A) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	209-234	tumor necrosis factor	Homo sapiens	50-59
9877282-2	1998	Furthermore, this effect was not LPS-specific, as TNF-alpha production was reduced by HO* radical scavengers to a similar extent upon stimulation of PBMC with immune complexes (IC), concanavalin A (Con A) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	236-239	tumor necrosis factor	Homo sapiens	50-59
9893038-7	1998	Phorbol 12-myristate 13-acetate pretreatment diminished the ability of BK to stimulate IL-8 production.	Tetradecanoylphorbol Acetate	0-31	kininogen 1	Homo sapiens	71-73
9893038-7	1998	Phorbol 12-myristate 13-acetate pretreatment diminished the ability of BK to stimulate IL-8 production.	Tetradecanoylphorbol Acetate	0-31	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
9885901-5	1998	By contrast, phorbol myristate acetate (PMA) and/or ionomycin-induced apoptosis had much slower kinetics, were preceded by an early increase of NF-kappaB/RelA-p50, AP-1 and NUR-77 activities, and were insensitive to proteasome inhibition.	Tetradecanoylphorbol Acetate	13-38	nuclear factor kappa B subunit 1	Homo sapiens	144-153
9885901-5	1998	By contrast, phorbol myristate acetate (PMA) and/or ionomycin-induced apoptosis had much slower kinetics, were preceded by an early increase of NF-kappaB/RelA-p50, AP-1 and NUR-77 activities, and were insensitive to proteasome inhibition.	Tetradecanoylphorbol Acetate	13-38	nuclear factor kappa B subunit 1	Homo sapiens	159-162
9885901-5	1998	By contrast, phorbol myristate acetate (PMA) and/or ionomycin-induced apoptosis had much slower kinetics, were preceded by an early increase of NF-kappaB/RelA-p50, AP-1 and NUR-77 activities, and were insensitive to proteasome inhibition.	Tetradecanoylphorbol Acetate	13-38	nuclear receptor subfamily 4 group A member 1	Homo sapiens	173-179
9885901-5	1998	By contrast, phorbol myristate acetate (PMA) and/or ionomycin-induced apoptosis had much slower kinetics, were preceded by an early increase of NF-kappaB/RelA-p50, AP-1 and NUR-77 activities, and were insensitive to proteasome inhibition.	Tetradecanoylphorbol Acetate	40-43	nuclear factor kappa B subunit 1	Homo sapiens	144-153
9885901-5	1998	By contrast, phorbol myristate acetate (PMA) and/or ionomycin-induced apoptosis had much slower kinetics, were preceded by an early increase of NF-kappaB/RelA-p50, AP-1 and NUR-77 activities, and were insensitive to proteasome inhibition.	Tetradecanoylphorbol Acetate	40-43	nuclear factor kappa B subunit 1	Homo sapiens	159-162
9885901-5	1998	By contrast, phorbol myristate acetate (PMA) and/or ionomycin-induced apoptosis had much slower kinetics, were preceded by an early increase of NF-kappaB/RelA-p50, AP-1 and NUR-77 activities, and were insensitive to proteasome inhibition.	Tetradecanoylphorbol Acetate	40-43	nuclear receptor subfamily 4 group A member 1	Homo sapiens	173-179
9876227-2	1998	CD45RA or CD45RO CD4 T cells were cultured for 4 days with phorbol myristate acetate (PMA) and ionomycin and either IL-4, IFN-gamma or IL-12 and their ability to proliferate and secrete IFN-gamma and IL-4 determined.	Tetradecanoylphorbol Acetate	86-89	CD4 molecule	Homo sapiens	0-3
9877451-7	1998	Additional studies with PMA-treated human whole blood cultures confirmed that pentoxifylline, db-cAMP, and adenosine reduced TNF-alpha production by leukocytes.	Tetradecanoylphorbol Acetate	24-27	tumor necrosis factor	Homo sapiens	125-134
9848784-3	1998	After evaluating intra- and interindividual variation in TGF-beta1 expression levels, the TGF-beta1 mRNA level in phorbol 12-myristate-13-acetate-stimulated (1 ng/ml) lymphocytes from individuals with different TGF-beta1 genotypes was also studied.	Tetradecanoylphorbol Acetate	114-145	transforming growth factor beta 1	Homo sapiens	90-99
9848784-3	1998	After evaluating intra- and interindividual variation in TGF-beta1 expression levels, the TGF-beta1 mRNA level in phorbol 12-myristate-13-acetate-stimulated (1 ng/ml) lymphocytes from individuals with different TGF-beta1 genotypes was also studied.	Tetradecanoylphorbol Acetate	114-145	transforming growth factor beta 1	Homo sapiens	90-99
9844106-4	1998	During a 3-day treatment with phorbol 12-myristate, 13-acetate (PMA), which induces differentiation of FLG 29.1 cells toward an osteoclast-like phenotype, the levels of Src and Fyn increased and the levels of Lyn decreased.	Tetradecanoylphorbol Acetate	64-67	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	169-172
9844106-4	1998	During a 3-day treatment with phorbol 12-myristate, 13-acetate (PMA), which induces differentiation of FLG 29.1 cells toward an osteoclast-like phenotype, the levels of Src and Fyn increased and the levels of Lyn decreased.	Tetradecanoylphorbol Acetate	64-67	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	209-212
9877448-3	1998	However, IL-1beta mRNA was not expressed unless the cells had been treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	80-105	interleukin 1 beta	Homo sapiens	9-17
9877448-3	1998	However, IL-1beta mRNA was not expressed unless the cells had been treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	107-110	interleukin 1 beta	Homo sapiens	9-17
9877448-4	1998	Both IL-1alpha and IL-1beta were detected in the GCM after the cells had been cultured with PMA, suggesting that IL-1 elaboration required PMA treatment.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 beta	Homo sapiens	19-27
9847438-5	1998	For this purpose, human lymphocytes were induced to express IL-4Ralpha chain by means of protein kinase C (PKC) activation with phorbol myristate acetate (PMA) or by triggering the Janus kinase-Stat pathway with IL-4 in the presence or absence of pharmacologic doses of dexamethasone.	Tetradecanoylphorbol Acetate	128-153	interleukin 4	Homo sapiens	60-64
9847438-5	1998	For this purpose, human lymphocytes were induced to express IL-4Ralpha chain by means of protein kinase C (PKC) activation with phorbol myristate acetate (PMA) or by triggering the Janus kinase-Stat pathway with IL-4 in the presence or absence of pharmacologic doses of dexamethasone.	Tetradecanoylphorbol Acetate	155-158	interleukin 4	Homo sapiens	60-64
9877448-4	1998	Both IL-1alpha and IL-1beta were detected in the GCM after the cells had been cultured with PMA, suggesting that IL-1 elaboration required PMA treatment.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 beta	Homo sapiens	5-9
9856820-6	1998	CD4+ T cells and CD8 + T cells from AD-H patients, cultured for 48 h with phorbol 12-myristate 13-acetate and ionomycin, released larger amounts of IL-4 and IL-13 but smaller amounts of IFN-gamma than both types of cells from AD-L patients or healthy controls.	Tetradecanoylphorbol Acetate	74-105	interleukin 4	Homo sapiens	148-152
9877448-8	1998	On the other hand, both the expression and secretion of IL-1beta required treatment with PMA.	Tetradecanoylphorbol Acetate	89-92	interleukin 1 beta	Homo sapiens	56-64
9877451-2	1998	We studied effects of diverse drugs on the formation of immunoreactive TNF-alpha in the human hepatoma cell lines HepG2 and Hep3B, in which TNF-alpha production was induced by treatment (3 h incubation periods) with interleukin-1beta (IL-1beta, 300 pg/ml) or phorbol myristate acetate (PMA, 100 nmol/l).	Tetradecanoylphorbol Acetate	259-284	tumor necrosis factor	Homo sapiens	71-80
9877451-2	1998	We studied effects of diverse drugs on the formation of immunoreactive TNF-alpha in the human hepatoma cell lines HepG2 and Hep3B, in which TNF-alpha production was induced by treatment (3 h incubation periods) with interleukin-1beta (IL-1beta, 300 pg/ml) or phorbol myristate acetate (PMA, 100 nmol/l).	Tetradecanoylphorbol Acetate	286-289	tumor necrosis factor	Homo sapiens	71-80
9850166-5	1998	PAF stimulation resulted in a very weak [compared to phorbol myristate acetate (PMA)] oxidative burst in bovine neutrophils, and only at high (10(-6) M) concentrations.	Tetradecanoylphorbol Acetate	53-78	PCNA-associated factor	Bos taurus	0-3
9850166-7	1998	Only high concentrations of PAF (10(-5) M) caused an increased rate of PMA-stimulated superoxide production, although lower doses of PAF did reduce the lag time preceding the PMA-induced oxidative burst.	Tetradecanoylphorbol Acetate	71-74	PCNA-associated factor	Bos taurus	28-31
9850166-7	1998	Only high concentrations of PAF (10(-5) M) caused an increased rate of PMA-stimulated superoxide production, although lower doses of PAF did reduce the lag time preceding the PMA-induced oxidative burst.	Tetradecanoylphorbol Acetate	175-178	PCNA-associated factor	Bos taurus	133-136
9856820-5	1998	Increased production of IL-4 and IL-13 in both CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells after 4 h in vitro stimulation with phorbol 12-myristate 13-acetate and ionomycin, was more prominent in AD-H patients than in AD-L patients or healthy controls, whereas IFN-gamma-producing CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells were relatively diminished in AD-H patients.	Tetradecanoylphorbol Acetate	129-160	interleukin 4	Homo sapiens	24-28
9856820-5	1998	Increased production of IL-4 and IL-13 in both CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells after 4 h in vitro stimulation with phorbol 12-myristate 13-acetate and ionomycin, was more prominent in AD-H patients than in AD-L patients or healthy controls, whereas IFN-gamma-producing CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells were relatively diminished in AD-H patients.	Tetradecanoylphorbol Acetate	129-160	interleukin 13	Homo sapiens	33-38
9856820-6	1998	CD4+ T cells and CD8 + T cells from AD-H patients, cultured for 48 h with phorbol 12-myristate 13-acetate and ionomycin, released larger amounts of IL-4 and IL-13 but smaller amounts of IFN-gamma than both types of cells from AD-L patients or healthy controls.	Tetradecanoylphorbol Acetate	74-105	CD4 molecule	Homo sapiens	0-3
9844925-4	1998	We have previously established that PMA-induced megakaryocyte differentiation of K562 cells requires the activity of the MEK/MAPK pathway (Herrera et al Exp Cell Res 1998; 238: 407-414).	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase kinase 7	Homo sapiens	121-124
9831704-8	1998	Treatment of VSMCs with the PPARgamma ligands troglitazone and the naturally occurring 15-deoxy-Delta12, 14-prostaglandin J2 (15d-PGJ2) decreased phorbol 12-myristate 13-acetate-induced MMP-9 mRNA and protein levels, as well as MMP-9 gelatinolytic activity in the supernatants in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	146-177	peroxisome proliferator activated receptor gamma	Homo sapiens	28-37
9843579-16	1998	Activation of PKC by phorbol ester (12-O-tetradecanoylphorbol-13-acetate) induced and attachment-dependent phosphorylation of both cPLA2 and ERK2 in suspension cells.	Tetradecanoylphorbol Acetate	36-72	mitogen-activated protein kinase 1	Homo sapiens	141-145
9828108-5	1998	Our results show that while high Pit-1 levels are found in exponentially growing HL-60 cells, a significant decrease occurs after induction of cells to differentiate along the macrophage lineage with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	238-241	POU class 1 homeobox 1	Homo sapiens	33-38
9862447-6	1998	Long-term incubation (24 h) of mesangial cells with TPA, which downregulates PKC-alpha, -delta, and -epsilon isoenzymes, resulted in a recovery of IL-1beta-stimulated neutral SMase activity as well as ceramide formation.	Tetradecanoylphorbol Acetate	52-55	interleukin 1 beta	Rattus norvegicus	147-155
9851700-6	1998	Functional analyses of the t-PA promoter using reporter-gene constructs transfected into C11STH endothelial cells demonstrate that the first 410 bp of the t-PA promoter confers an increase in reporter-gene activity on treatment with 4beta-phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	233-270	plasminogen activator, tissue type	Homo sapiens	27-31
9851700-6	1998	Functional analyses of the t-PA promoter using reporter-gene constructs transfected into C11STH endothelial cells demonstrate that the first 410 bp of the t-PA promoter confers an increase in reporter-gene activity on treatment with 4beta-phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	233-270	plasminogen activator, tissue type	Homo sapiens	155-159
9851700-6	1998	Functional analyses of the t-PA promoter using reporter-gene constructs transfected into C11STH endothelial cells demonstrate that the first 410 bp of the t-PA promoter confers an increase in reporter-gene activity on treatment with 4beta-phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	272-275	plasminogen activator, tissue type	Homo sapiens	27-31
9851700-6	1998	Functional analyses of the t-PA promoter using reporter-gene constructs transfected into C11STH endothelial cells demonstrate that the first 410 bp of the t-PA promoter confers an increase in reporter-gene activity on treatment with 4beta-phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	272-275	plasminogen activator, tissue type	Homo sapiens	155-159
9797142-1	1998	Previously, we have shown that phorbol ester (PMA) induces p21(WAF1/CIP1)-dependent growth arrest in SKBr3 breast cancer and LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	46-49	cyclin dependent kinase inhibitor 1A	Homo sapiens	59-62
9797142-1	1998	Previously, we have shown that phorbol ester (PMA) induces p21(WAF1/CIP1)-dependent growth arrest in SKBr3 breast cancer and LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	46-49	cyclin dependent kinase inhibitor 1A	Homo sapiens	63-72
9797142-3	1998	Similarly, PD98059, a specific inhibitor of MEK, abolished p21(WAF1/CIP1) induction and PMA-induced growth arrest.	Tetradecanoylphorbol Acetate	88-91	mitogen-activated protein kinase kinase 7	Homo sapiens	44-47
9844735-4	1998	Immunoblot analysis of membrane fractions showed increases in PKC alpha and beta immunoreactivities after treatment with 5 mM, 20 mM glucose and 1 microM TPA.	Tetradecanoylphorbol Acetate	154-157	protein kinase C alpha	Homo sapiens	62-71
9813161-4	1998	Treatment with the protein kinase C inhibitors bisindolylmaleimide I and chelerythrine mimicked the augmentation effect of IGF1, whereas PMA blocked enhancement of Mn2+ influx by IGF1.	Tetradecanoylphorbol Acetate	137-140	insulin like growth factor 1	Homo sapiens	179-183
9815052-7	1998	12-O-tetradecanoylphorbol 13-acetate (TPA) also reduced the magnitude of the potentiation of amylase release caused by VIP plus CCK-8 or CCh, although TPA itself decreased neither VIP-stimulated adenylyl cyclase activity nor intracellular cAMP accumulation.	Tetradecanoylphorbol Acetate	0-36	vasoactive intestinal peptide	Rattus norvegicus	119-122
9815052-7	1998	12-O-tetradecanoylphorbol 13-acetate (TPA) also reduced the magnitude of the potentiation of amylase release caused by VIP plus CCK-8 or CCh, although TPA itself decreased neither VIP-stimulated adenylyl cyclase activity nor intracellular cAMP accumulation.	Tetradecanoylphorbol Acetate	38-41	vasoactive intestinal peptide	Rattus norvegicus	119-122
9815052-7	1998	12-O-tetradecanoylphorbol 13-acetate (TPA) also reduced the magnitude of the potentiation of amylase release caused by VIP plus CCK-8 or CCh, although TPA itself decreased neither VIP-stimulated adenylyl cyclase activity nor intracellular cAMP accumulation.	Tetradecanoylphorbol Acetate	38-41	vasoactive intestinal peptide	Rattus norvegicus	180-183
9891495-0	1998	Cytoskeletal PKC and ERK/MAPK activation in response to N-nitrosamines and phorbol 12-myristate 13-acetate in gastric adenocarcinoma cells.	Tetradecanoylphorbol Acetate	75-106	mitogen-activated protein kinase 1	Homo sapiens	21-24
9891495-4	1998	At 60 minutes, PMA caused translocation of PKC from cytosol to plasma membranes and increased plasma membrane ERK/MAPK activities; 24-hour treatment with PMA resulted in downregulation of membrane PKC and ERK/MAPK, but an increase in cytoskeletal PKC and ERK/MAPK.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 1	Homo sapiens	110-113
9891495-4	1998	At 60 minutes, PMA caused translocation of PKC from cytosol to plasma membranes and increased plasma membrane ERK/MAPK activities; 24-hour treatment with PMA resulted in downregulation of membrane PKC and ERK/MAPK, but an increase in cytoskeletal PKC and ERK/MAPK.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 1	Homo sapiens	205-208
9891495-4	1998	At 60 minutes, PMA caused translocation of PKC from cytosol to plasma membranes and increased plasma membrane ERK/MAPK activities; 24-hour treatment with PMA resulted in downregulation of membrane PKC and ERK/MAPK, but an increase in cytoskeletal PKC and ERK/MAPK.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 1	Homo sapiens	205-208
9891495-4	1998	At 60 minutes, PMA caused translocation of PKC from cytosol to plasma membranes and increased plasma membrane ERK/MAPK activities; 24-hour treatment with PMA resulted in downregulation of membrane PKC and ERK/MAPK, but an increase in cytoskeletal PKC and ERK/MAPK.	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase 1	Homo sapiens	110-113
9891495-4	1998	At 60 minutes, PMA caused translocation of PKC from cytosol to plasma membranes and increased plasma membrane ERK/MAPK activities; 24-hour treatment with PMA resulted in downregulation of membrane PKC and ERK/MAPK, but an increase in cytoskeletal PKC and ERK/MAPK.	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase 1	Homo sapiens	205-208
9891495-4	1998	At 60 minutes, PMA caused translocation of PKC from cytosol to plasma membranes and increased plasma membrane ERK/MAPK activities; 24-hour treatment with PMA resulted in downregulation of membrane PKC and ERK/MAPK, but an increase in cytoskeletal PKC and ERK/MAPK.	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase 1	Homo sapiens	205-208
9891495-7	1998	The converging action of NA and PMA on cytoskeletal PKC and ERK/MAPK activities suggests that both agents may focus on a common cellular target.	Tetradecanoylphorbol Acetate	32-35	mitogen-activated protein kinase 1	Homo sapiens	60-63
9837745-4	1998	These B cells expressed p40 and p35 mRNA, and phorbol myristate acetate (PMA) stimulation strongly enhanced p40 and p70 production.	Tetradecanoylphorbol Acetate	46-71	ubiquitin associated and SH3 domain containing B	Homo sapiens	116-119
9837745-4	1998	These B cells expressed p40 and p35 mRNA, and phorbol myristate acetate (PMA) stimulation strongly enhanced p40 and p70 production.	Tetradecanoylphorbol Acetate	73-76	ubiquitin associated and SH3 domain containing B	Homo sapiens	116-119
9837747-4	1998	As for mechanisms of action, KT-90 and morphine induced apoptosis, and inhibited tumor necrosis factor alpha (TNF-alpha) gene expression induced by tumor promoters, okadaic acid and 12-O-tetradecanoylphorbol-13-acetate, associated with reduction of NF-kappaB DNA binding activity.	Tetradecanoylphorbol Acetate	182-218	tumor necrosis factor	Homo sapiens	81-108
9837747-4	1998	As for mechanisms of action, KT-90 and morphine induced apoptosis, and inhibited tumor necrosis factor alpha (TNF-alpha) gene expression induced by tumor promoters, okadaic acid and 12-O-tetradecanoylphorbol-13-acetate, associated with reduction of NF-kappaB DNA binding activity.	Tetradecanoylphorbol Acetate	182-218	tumor necrosis factor	Homo sapiens	110-119
9802987-5	1998	IL-8 was retained in these storage organelles for several days after the removal of the stimulus and could be released by EC secretagogues such as phorbol myristate acetate, the calcium ionophore A23187, and histamine.	Tetradecanoylphorbol Acetate	147-172	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9870082-4	1998	In another set of experiments cells were treated with ET-1 and BQ485, an ET-A receptor antagonist, or with phorbol 12-myristate-13 acetate (PMA), an activator of protein kinase C. RESULTS: ET-1 reduced both basal and human chorionic gonadotropin-induced progesterone production at all examined times, similarly PMA inhibited basal progesterone synthesis.	Tetradecanoylphorbol Acetate	107-138	endothelin 1	Homo sapiens	189-193
9844735-5	1998	Translocations of PKC alpha after treatment with glucose and TPA were greater than those of PKC beta in membrane fractions.	Tetradecanoylphorbol Acetate	61-64	protein kinase C alpha	Homo sapiens	18-27
9794480-11	1998	Expression of the electron carrier adrenodoxin (ADX), which is a part of the cytochrome P450scc enzyme system, was very low in nonstimulated cells but was dramatically elevated in FK- and 8-Br-cAMP-stimulated cells, whereas no reduction of ADX was evident in cells costimulated with FK and TPA.	Tetradecanoylphorbol Acetate	290-293	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	77-95
9799444-9	1998	Exposure of 42GPA9 cells for 24 h to cAMP and 12-O-tetradecanoylphorbol-13-acetate greatly reduces the Cx43 staining at cell-cell contacts and concomitantly increases the cytoplasmic staining, suggesting that these agents alter the trafficking of Cx43 to the plasma membrane.	Tetradecanoylphorbol Acetate	46-82	gap junction protein, alpha 1	Mus musculus	103-107
9799444-9	1998	Exposure of 42GPA9 cells for 24 h to cAMP and 12-O-tetradecanoylphorbol-13-acetate greatly reduces the Cx43 staining at cell-cell contacts and concomitantly increases the cytoplasmic staining, suggesting that these agents alter the trafficking of Cx43 to the plasma membrane.	Tetradecanoylphorbol Acetate	46-82	gap junction protein, alpha 1	Mus musculus	247-251
9792541-8	1998	The effect of tolbutamide was blocked either by inhibition of PKC or when phorbol ester-sensitive PKC isoforms were maximally stimulated by TPA.	Tetradecanoylphorbol Acetate	140-143	protein kinase C, alpha	Mus musculus	98-101
9792541-12	1998	Neither tolbutamide nor glibenclamide elicited translocation of any isoform of PKC in intact or permeabilized beta-cells under conditions in which TPA evoked a marked redistribution of PKC alpha- and epsilon-isoforms.	Tetradecanoylphorbol Acetate	147-150	protein kinase C, alpha	Mus musculus	185-194
9794414-1	1998	Expression of human MHC HLA-DRA class II gene can be up-regulated in B cells by Ig cross-linking as well as by phorbol esters such as 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	134-171	solute carrier family 26 member 3	Homo sapiens	28-31
9865597-3	1998	The release of TNF-alpha required both a Ca2(+)-ATPase inhibitor and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	69-105	tumor necrosis factor	Rattus norvegicus	15-24
9865597-3	1998	The release of TNF-alpha required both a Ca2(+)-ATPase inhibitor and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	107-110	tumor necrosis factor	Rattus norvegicus	15-24
9794414-1	1998	Expression of human MHC HLA-DRA class II gene can be up-regulated in B cells by Ig cross-linking as well as by phorbol esters such as 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	173-176	solute carrier family 26 member 3	Homo sapiens	28-31
9794414-5	1998	Western analysis performed on cellular fractions of resting cells and of TPA-activated cells revealed abundant expression of classical PKC-alpha (cPKC-alpha), cPKC-betaII, and atypical PKC-zeta isoforms and identified a sustained translocation of cPKC-alpha and cPKC-betaII from the cytosolic compartment to membranes.	Tetradecanoylphorbol Acetate	73-76	protein kinase C alpha	Homo sapiens	135-144
9823934-9	1998	The expression of Bax was clearly induced only on IL-2-stimulated or PMA-plus-ionomycin-stimulated PBLs and that of other Bcl-2 family proteins such as Bcl-x and Bad could not be detected on human PBLs, including IL-2-stimulated or PMA-plus-ionomycin-stimulated PBLs.	Tetradecanoylphorbol Acetate	69-72	BCL2 associated X, apoptosis regulator	Homo sapiens	18-21
9823934-9	1998	The expression of Bax was clearly induced only on IL-2-stimulated or PMA-plus-ionomycin-stimulated PBLs and that of other Bcl-2 family proteins such as Bcl-x and Bad could not be detected on human PBLs, including IL-2-stimulated or PMA-plus-ionomycin-stimulated PBLs.	Tetradecanoylphorbol Acetate	232-235	BCL2 associated X, apoptosis regulator	Homo sapiens	18-21
9794432-2	1998	IFN-gamma and TNF-alpha, alone or in combination, caused a significant up-regulation of the NADPH oxidase system as reflected by an enhancement of the PMA-stimulated superoxide release, cytochrome b558 content, and expression of gp91-phox and p47-phox genes on both days 2 and 7 of cell culture.	Tetradecanoylphorbol Acetate	151-154	interferon gamma	Homo sapiens	0-9
9794432-2	1998	IFN-gamma and TNF-alpha, alone or in combination, caused a significant up-regulation of the NADPH oxidase system as reflected by an enhancement of the PMA-stimulated superoxide release, cytochrome b558 content, and expression of gp91-phox and p47-phox genes on both days 2 and 7 of cell culture.	Tetradecanoylphorbol Acetate	151-154	tumor necrosis factor	Homo sapiens	14-23
9794414-10	1998	Together, these results show that activated HLA-DRA expression in response to TPA treatment is strictly dependent on PKC activation acting on the X2 box of the DRA promoter and that selective inhibition of PKC enzymatic activity does not influence subcellular localization of expressed PKC isoenzymes.	Tetradecanoylphorbol Acetate	78-81	solute carrier family 26 member 3	Homo sapiens	48-51
9794432-6	1998	Indomethacin inhibited only the PMA-stimulated superoxide release of THP-1 cells differentiated with IFN-gamma and TNF-alpha during 7 days.	Tetradecanoylphorbol Acetate	32-35	interferon gamma	Homo sapiens	101-110
9794414-10	1998	Together, these results show that activated HLA-DRA expression in response to TPA treatment is strictly dependent on PKC activation acting on the X2 box of the DRA promoter and that selective inhibition of PKC enzymatic activity does not influence subcellular localization of expressed PKC isoenzymes.	Tetradecanoylphorbol Acetate	78-81	protein kinase C alpha	Homo sapiens	117-120
9794432-6	1998	Indomethacin inhibited only the PMA-stimulated superoxide release of THP-1 cells differentiated with IFN-gamma and TNF-alpha during 7 days.	Tetradecanoylphorbol Acetate	32-35	tumor necrosis factor	Homo sapiens	115-124
9794414-10	1998	Together, these results show that activated HLA-DRA expression in response to TPA treatment is strictly dependent on PKC activation acting on the X2 box of the DRA promoter and that selective inhibition of PKC enzymatic activity does not influence subcellular localization of expressed PKC isoenzymes.	Tetradecanoylphorbol Acetate	78-81	solute carrier family 26 member 3	Homo sapiens	160-163
9855300-5	1998	The chemotactic effect of Abeta (25-35) on microglia was desensitized by pretreatment of microglia with 1 ng/ml 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	150-153	amyloid beta precursor protein	Homo sapiens	26-31
9802902-7	1998	However, treatment of ARNO transfectants with the PKC agonist phorbol 12-myristate 13-acetate results in the dramatic redistribution of ARNO, ARF6, and actin into membrane protrusions resembling lamellipodia.	Tetradecanoylphorbol Acetate	62-93	cytohesin 2	Homo sapiens	22-26
9802902-7	1998	However, treatment of ARNO transfectants with the PKC agonist phorbol 12-myristate 13-acetate results in the dramatic redistribution of ARNO, ARF6, and actin into membrane protrusions resembling lamellipodia.	Tetradecanoylphorbol Acetate	62-93	cytohesin 2	Homo sapiens	136-140
9832394-7	1998	On the other hand, the time-course of translocation/down-regulation of protein kinase C alpha and protein kinase C epsilon induced by PMA was in good correlation with the time-course of PMA-induced [methyl-3H]thymidine incorporation.	Tetradecanoylphorbol Acetate	134-137	protein kinase C alpha	Homo sapiens	71-93
9855300-5	1998	The chemotactic effect of Abeta (25-35) on microglia was desensitized by pretreatment of microglia with 1 ng/ml 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	112-148	amyloid beta precursor protein	Homo sapiens	26-31
9858322-4	1998	However, oxidative signals resulted in a dose-dependent suppression of TNF-alpha protein production and transcriptional activation in T cells stimulated with the lectin phytohemagglutinin (PHA) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	198-223	tumor necrosis factor	Homo sapiens	71-80
9858322-4	1998	However, oxidative signals resulted in a dose-dependent suppression of TNF-alpha protein production and transcriptional activation in T cells stimulated with the lectin phytohemagglutinin (PHA) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	225-228	tumor necrosis factor	Homo sapiens	71-80
9790811-7	1998	PMA treatment induced spreading of the FBGN bound cells.	Tetradecanoylphorbol Acetate	0-3	fibrinogen beta chain	Homo sapiens	39-43
10397453-4	1998	EBV-EA induction by TPA was related to the activation of protein kinase C and phospholipase A2.	Tetradecanoylphorbol Acetate	20-23	phospholipase A2 group IB	Homo sapiens	78-94
10397459-3	1998	This result was consistent with the findings that PMA-stimulated activities of NF-kappaB were markedly increased in the NF-kappaB subunit-transfected cells in comparison with their parental cells and PMA-induced differentiation was enhanced by pretreatment with IkappaB-alpha antisense oligonucleotide in the NF-kappaB subunit-transfected cells.	Tetradecanoylphorbol Acetate	50-53	NFKB inhibitor alpha	Homo sapiens	262-275
10397459-3	1998	This result was consistent with the findings that PMA-stimulated activities of NF-kappaB were markedly increased in the NF-kappaB subunit-transfected cells in comparison with their parental cells and PMA-induced differentiation was enhanced by pretreatment with IkappaB-alpha antisense oligonucleotide in the NF-kappaB subunit-transfected cells.	Tetradecanoylphorbol Acetate	200-203	NFKB inhibitor alpha	Homo sapiens	262-275
10397459-5	1998	However, PMA-induced differentiation was blocked by pretreatment with PD98059, a specific inhibitor of MEK, in both parental and NF-kappaB-transfected cells.	Tetradecanoylphorbol Acetate	9-12	mitogen-activated protein kinase kinase 7	Homo sapiens	103-106
9784628-4	1998	Phorbol myristate acetate-induced PLD activation was also inhibited in C3 exoenzyme-treated cells, but the inhibition was only partial.	Tetradecanoylphorbol Acetate	0-25	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	34-37
9756942-5	1998	Phorbol 12-myristate 13-acetate and LPS also induce an increase in tumor necrosis factor-alpha (TNF-alpha) mRNA levels, which suggest that this cytokine may mediate some of the effects triggered by these agents, since addition of TNF-alpha alone can increase N1 and N5 transport activities by a mechanism that also depends on protein kinase C activation.	Tetradecanoylphorbol Acetate	0-31	tumor necrosis factor	Homo sapiens	67-94
9765228-7	1998	Phosphorylation of ERK in response to CCh was mimicked by the protein kinase C (PKC) activator, phorbol myristate acetate (100 nM), but was not altered by the PKC inhibitor GF 109203X (1 microM).	Tetradecanoylphorbol Acetate	96-121	mitogen-activated protein kinase 1	Homo sapiens	19-22
9804192-3	1998	The antiapoptotic effect of TPA was accompanied by phosphorylation of extracelluar signal-regulated kinase 1/2 (ERK1/2).	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 3	Homo sapiens	112-118
9804192-4	1998	Pretreatment of cells with MEK inhibitor, PD98059, inhibited TPA-induced phosphorylation of ERK1/2 and the cytoprotective ability of TPA.	Tetradecanoylphorbol Acetate	61-64	mitogen-activated protein kinase kinase 7	Homo sapiens	27-30
9804192-4	1998	Pretreatment of cells with MEK inhibitor, PD98059, inhibited TPA-induced phosphorylation of ERK1/2 and the cytoprotective ability of TPA.	Tetradecanoylphorbol Acetate	61-64	mitogen-activated protein kinase 3	Homo sapiens	92-98
9804192-4	1998	Pretreatment of cells with MEK inhibitor, PD98059, inhibited TPA-induced phosphorylation of ERK1/2 and the cytoprotective ability of TPA.	Tetradecanoylphorbol Acetate	133-136	mitogen-activated protein kinase kinase 7	Homo sapiens	27-30
9763633-11	1998	The inhibitory effect of neomycin on chloride currents can be reversed by the PKC activator phorbol 12-myristate, 13-acetate (PMA).	Tetradecanoylphorbol Acetate	92-124	proline rich transmembrane protein 2	Homo sapiens	78-81
9763633-11	1998	The inhibitory effect of neomycin on chloride currents can be reversed by the PKC activator phorbol 12-myristate, 13-acetate (PMA).	Tetradecanoylphorbol Acetate	126-129	proline rich transmembrane protein 2	Homo sapiens	78-81
9756922-1	1998	Sialyl-Lex (sLex) antigen expression recognized by KM93 monoclonal antibody was significantly down-regulated during differentiation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in human pre-B lymphocytic leukemia cell line KM3.	Tetradecanoylphorbol Acetate	143-179	fucosyltransferase 4	Homo sapiens	7-10
9756922-1	1998	Sialyl-Lex (sLex) antigen expression recognized by KM93 monoclonal antibody was significantly down-regulated during differentiation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in human pre-B lymphocytic leukemia cell line KM3.	Tetradecanoylphorbol Acetate	181-184	fucosyltransferase 4	Homo sapiens	7-10
9778356-5	1998	The PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) and the phosphoprotein phosphatase inhibitor okadaic acid (OA) produced increased phosphorylation of AChR delta-subunits on the three serine residues that were phosphorylated by purified PKC in vitro.	Tetradecanoylphorbol Acetate	18-54	cholinergic receptor nicotinic delta subunit	Gallus gallus	162-166
9778356-5	1998	The PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) and the phosphoprotein phosphatase inhibitor okadaic acid (OA) produced increased phosphorylation of AChR delta-subunits on the three serine residues that were phosphorylated by purified PKC in vitro.	Tetradecanoylphorbol Acetate	56-59	cholinergic receptor nicotinic delta subunit	Gallus gallus	162-166
9778356-7	1998	The effects of TPA and OA included an increase in the proportion of surface AChR that is extracted in Triton X-100, as well as the spreading of AChR from cluster regions to adjacent areas of the muscle cell surface.	Tetradecanoylphorbol Acetate	15-18	cholinergic receptor nicotinic delta subunit	Gallus gallus	76-80
9756942-5	1998	Phorbol 12-myristate 13-acetate and LPS also induce an increase in tumor necrosis factor-alpha (TNF-alpha) mRNA levels, which suggest that this cytokine may mediate some of the effects triggered by these agents, since addition of TNF-alpha alone can increase N1 and N5 transport activities by a mechanism that also depends on protein kinase C activation.	Tetradecanoylphorbol Acetate	0-31	tumor necrosis factor	Homo sapiens	96-105
9770354-1	1998	The functional role of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in leukemic cell G1 arrest, differentiation, and apoptosis induced by two PKC activators (PMA and bryostatin 1) was examined using antisense-expressing lines [U937/p21AS(F4) and U937/p21AS(B8)].	Tetradecanoylphorbol Acetate	166-169	cyclin dependent kinase inhibitor 1A	Homo sapiens	61-64
9756942-5	1998	Phorbol 12-myristate 13-acetate and LPS also induce an increase in tumor necrosis factor-alpha (TNF-alpha) mRNA levels, which suggest that this cytokine may mediate some of the effects triggered by these agents, since addition of TNF-alpha alone can increase N1 and N5 transport activities by a mechanism that also depends on protein kinase C activation.	Tetradecanoylphorbol Acetate	0-31	tumor necrosis factor	Homo sapiens	230-239
9770354-1	1998	The functional role of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in leukemic cell G1 arrest, differentiation, and apoptosis induced by two PKC activators (PMA and bryostatin 1) was examined using antisense-expressing lines [U937/p21AS(F4) and U937/p21AS(B8)].	Tetradecanoylphorbol Acetate	166-169	cyclin dependent kinase inhibitor 1A	Homo sapiens	65-69
9760255-0	1998	Analysis of the TPA regulatory element in the genomic poly(ADP-ribose) synthetase gene in human leukemia U937 cells.	Tetradecanoylphorbol Acetate	16-19	poly(ADP-ribose) polymerase 1	Homo sapiens	54-81
9770354-1	1998	The functional role of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in leukemic cell G1 arrest, differentiation, and apoptosis induced by two PKC activators (PMA and bryostatin 1) was examined using antisense-expressing lines [U937/p21AS(F4) and U937/p21AS(B8)].	Tetradecanoylphorbol Acetate	166-169	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-74
9770354-2	1998	Following incubation with 10 nM PMA (24 h), antisense-expressing cells displayed induction of p27(KIP1) but not of p21, whereas empty vector-containing cells (U937/pREP4) exhibited induction of both p21 and p27.	Tetradecanoylphorbol Acetate	32-35	dynactin subunit 6	Homo sapiens	94-97
9770354-2	1998	Following incubation with 10 nM PMA (24 h), antisense-expressing cells displayed induction of p27(KIP1) but not of p21, whereas empty vector-containing cells (U937/pREP4) exhibited induction of both p21 and p27.	Tetradecanoylphorbol Acetate	32-35	cyclin dependent kinase inhibitor 1A	Homo sapiens	199-202
9770354-2	1998	Following incubation with 10 nM PMA (24 h), antisense-expressing cells displayed induction of p27(KIP1) but not of p21, whereas empty vector-containing cells (U937/pREP4) exhibited induction of both p21 and p27.	Tetradecanoylphorbol Acetate	32-35	dynactin subunit 6	Homo sapiens	207-210
9763600-7	1998	Strikingly, IL-2 production induced by PMA and ionomycin was unaffected by C3 treatment.	Tetradecanoylphorbol Acetate	39-42	interleukin 2	Homo sapiens	12-16
9801139-4	1998	Treatment with the PK-C activator phorbol 12-myristate 13-acetate (PMA) further increases the level of maximal nuclear accumulation and the initial nuclear import rate.	Tetradecanoylphorbol Acetate	34-65	proline rich transmembrane protein 2	Homo sapiens	19-23
9801139-4	1998	Treatment with the PK-C activator phorbol 12-myristate 13-acetate (PMA) further increases the level of maximal nuclear accumulation and the initial nuclear import rate.	Tetradecanoylphorbol Acetate	67-70	proline rich transmembrane protein 2	Homo sapiens	19-23
10100885-3	1998	FMLP increased intracellular free Ca2+ concentration ([Ca2+]i), which was slightly suppressed by PMA and completely inhibited by an intracellular Ca2+ chelating agent, O,O"-bis(2-aminophenyl)ethyleneglycol-N,N,N",N"-tetraacetic acid tetraacetoxymethyl ester (BAPTA-AM).	Tetradecanoylphorbol Acetate	97-100	formyl peptide receptor 1	Homo sapiens	0-4
9774148-7	1998	Down-modulation of PKC alpha and delta by 12-O-tetradecanoylphorbol-13-acetate (TPA) did not affect the drug accumulation by bryostatin 1.	Tetradecanoylphorbol Acetate	80-83	protein kinase C alpha	Homo sapiens	19-28
9831895-5	1998	Pretreatment of TECs with phorbol 12-myristate 13-acetate (PMA, 1 microM) for 30 min attenuated the BK-induced IPs formation and Ca2+ mobilization.	Tetradecanoylphorbol Acetate	26-57	kininogen 1	Canis lupus familiaris	100-102
9831895-5	1998	Pretreatment of TECs with phorbol 12-myristate 13-acetate (PMA, 1 microM) for 30 min attenuated the BK-induced IPs formation and Ca2+ mobilization.	Tetradecanoylphorbol Acetate	59-62	kininogen 1	Canis lupus familiaris	100-102
9831895-9	1998	Prior treatment of TECs with staurosporine (1 microM), a PKC inhibitor, inhibited the ability of PMA to attenuate BK-induced responses, suggesting that the inhibitory effect of PMA is mediated through the activation of PKC.	Tetradecanoylphorbol Acetate	97-100	kininogen 1	Canis lupus familiaris	114-116
9763144-4	1998	PMA pretreatment of calvariae greatly blocked IL-6 mRNA induction by a subsequent dose of PMA and decreased induction by PTH and forskolin to a much lesser extent.	Tetradecanoylphorbol Acetate	0-3	interleukin 6	Mus musculus	46-50
9808174-4	1998	Upon phorbol 12-myristate 13-acetate + ionomycin stimulation, accumulation of cytoplasmic IL-2 was similar to that observed in freshly isolated cells, but no IL-4- or IFN-gamma-positive cells were detected.	Tetradecanoylphorbol Acetate	5-36	interleukin 2	Homo sapiens	90-94
9796963-8	1998	In another group of 28 patients (three individuals from the first group), the frequency of abnormal NFkappaB activation was studied using electrophoretic mobility shift assays after activation of T cells with phorbol myristate acetate/ionomycin or anti-CD3 monoclonal antibody.	Tetradecanoylphorbol Acetate	209-234	nuclear factor kappa B subunit 1	Homo sapiens	100-108
9796963-14	1998	Abnormal NFkappaB activation after stimulation with phorbol myristate acetate/ionomycin and/or anti-CD3 monoclonal antibody was found in 59% of patients (17 of 28) and was not accounted for by the advanced age of the study cohort.	Tetradecanoylphorbol Acetate	52-77	nuclear factor kappa B subunit 1	Homo sapiens	9-17
9806167-6	1998	In addition, TPA-treated, papilloma-bearing F1 mice which carried the A(vy) allele, but not F1 mice which did not carry the A(vy) allele, exhibited a syndrome of humoral hypercalcemia mediated by parathyroid hormone-related protein (PTHrP) that led to weight loss, hypercalcemia and hypophosphatemia.	Tetradecanoylphorbol Acetate	13-16	parathyroid hormone-like peptide	Mus musculus	196-231
9806167-6	1998	In addition, TPA-treated, papilloma-bearing F1 mice which carried the A(vy) allele, but not F1 mice which did not carry the A(vy) allele, exhibited a syndrome of humoral hypercalcemia mediated by parathyroid hormone-related protein (PTHrP) that led to weight loss, hypercalcemia and hypophosphatemia.	Tetradecanoylphorbol Acetate	13-16	parathyroid hormone-like peptide	Mus musculus	233-238
9809627-2	1998	Pretreatment of HL-60 or THP-1 cells with phorbol myristate acetate (PMA) enhanced their capacity to induce IL-8 production by T98G cells.	Tetradecanoylphorbol Acetate	42-67	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
9774360-5	1998	Extracellular stimuli such as platelet-derived growth factor (PDGF), 12-O-tetradecanoylphorbol 13-acetate (TPA), and angiotensin II, which activated ERK but not SAPK/p38 MAP kinase, induced a transient induction of MKP-1 mRNA and its intracellular protein.	Tetradecanoylphorbol Acetate	69-105	mitogen-activated protein kinase 1	Homo sapiens	149-152
9774360-5	1998	Extracellular stimuli such as platelet-derived growth factor (PDGF), 12-O-tetradecanoylphorbol 13-acetate (TPA), and angiotensin II, which activated ERK but not SAPK/p38 MAP kinase, induced a transient induction of MKP-1 mRNA and its intracellular protein.	Tetradecanoylphorbol Acetate	69-105	dual specificity phosphatase 1	Homo sapiens	215-220
9774360-5	1998	Extracellular stimuli such as platelet-derived growth factor (PDGF), 12-O-tetradecanoylphorbol 13-acetate (TPA), and angiotensin II, which activated ERK but not SAPK/p38 MAP kinase, induced a transient induction of MKP-1 mRNA and its intracellular protein.	Tetradecanoylphorbol Acetate	107-110	mitogen-activated protein kinase 1	Homo sapiens	149-152
9774360-5	1998	Extracellular stimuli such as platelet-derived growth factor (PDGF), 12-O-tetradecanoylphorbol 13-acetate (TPA), and angiotensin II, which activated ERK but not SAPK/p38 MAP kinase, induced a transient induction of MKP-1 mRNA and its intracellular protein.	Tetradecanoylphorbol Acetate	107-110	dual specificity phosphatase 1	Homo sapiens	215-220
9759900-8	1998	However, PGE2, forskolin, and PMA enhanced the stability of IL-8 mRNA transcripts, suggesting the involvement of posttranscriptional regulation.	Tetradecanoylphorbol Acetate	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9809619-4	1998	Phorbol myristate acetate (PMA) greatly enhanced IFN yields in the presence of ionophores but had no significant influence on IL-4 production.	Tetradecanoylphorbol Acetate	0-25	interferon alpha 1	Homo sapiens	49-52
9809619-4	1998	Phorbol myristate acetate (PMA) greatly enhanced IFN yields in the presence of ionophores but had no significant influence on IL-4 production.	Tetradecanoylphorbol Acetate	27-30	interferon alpha 1	Homo sapiens	49-52
9809627-2	1998	Pretreatment of HL-60 or THP-1 cells with phorbol myristate acetate (PMA) enhanced their capacity to induce IL-8 production by T98G cells.	Tetradecanoylphorbol Acetate	69-72	GLI family zinc finger 2	Homo sapiens	25-30
9809627-2	1998	Pretreatment of HL-60 or THP-1 cells with phorbol myristate acetate (PMA) enhanced their capacity to induce IL-8 production by T98G cells.	Tetradecanoylphorbol Acetate	42-67	GLI family zinc finger 2	Homo sapiens	25-30
9809627-2	1998	Pretreatment of HL-60 or THP-1 cells with phorbol myristate acetate (PMA) enhanced their capacity to induce IL-8 production by T98G cells.	Tetradecanoylphorbol Acetate	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
9766632-5	1998	Despite their large disparity in potency, IL-8 and LPS printing were additive using fMLP, a receptor-dependent stimulator, and synergistic using the post-receptor, protein kinase C activator, phorbol 12-myristate 13-acetate (PMA) to trigger the respiratory burst.	Tetradecanoylphorbol Acetate	192-223	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9766631-5	1998	Effects of interleukin-4 and of phorbol 12-myristate 13-acetate on CD134 expression could be blocked by the protein kinase inhibitor staurosporin.	Tetradecanoylphorbol Acetate	32-63	TNF receptor superfamily member 4	Homo sapiens	67-72
9797107-10	1998	Phorbol 12-myristate 13-acetate (30 nM) and IL-1beta (100 ng/mL) increased COX-2 promoter activity by 2.6-fold and 2.2-fold, respectively.	Tetradecanoylphorbol Acetate	0-31	prostaglandin-endoperoxide synthase 2	Homo sapiens	75-80
9766632-5	1998	Despite their large disparity in potency, IL-8 and LPS printing were additive using fMLP, a receptor-dependent stimulator, and synergistic using the post-receptor, protein kinase C activator, phorbol 12-myristate 13-acetate (PMA) to trigger the respiratory burst.	Tetradecanoylphorbol Acetate	225-228	C-X-C motif chemokine ligand 8	Homo sapiens	42-46
9758735-15	1998	In comparison, phorbol myristate acetate, a protein kinase C (PKC) activator, restored TNF and PCA production despite the presence of IL-10.	Tetradecanoylphorbol Acetate	15-40	tumor necrosis factor	Homo sapiens	87-90
9916491-2	1998	Luminol-dependent Chemiluminescence (LmCL) responses were inhibited by a high concentration of IFN-alpha (more than 1 x 10(4) IU/ml) when opsonized zymosan (OZ) and phorbol 12-myristate 13-acetate (PMA) were used as stimulants.	Tetradecanoylphorbol Acetate	165-196	interferon alpha 1	Homo sapiens	95-104
9877207-6	1998	ERalpha/E2 also induced a two-fold potentiation of TPA-mediated expression of beta-galactosidase under the control of TREs in HeLa cells but not in HEK-293 cells.	Tetradecanoylphorbol Acetate	51-54	estrogen receptor 1	Homo sapiens	0-7
9916491-2	1998	Luminol-dependent Chemiluminescence (LmCL) responses were inhibited by a high concentration of IFN-alpha (more than 1 x 10(4) IU/ml) when opsonized zymosan (OZ) and phorbol 12-myristate 13-acetate (PMA) were used as stimulants.	Tetradecanoylphorbol Acetate	198-201	interferon alpha 1	Homo sapiens	95-104
9738001-6	1998	The further expression of IRS-1 in 3Y1-GLUT4myc-IR cells led to stimulation of glycogen synthesis but not to glucose uptake or GLUT4myc translocation in response to insulin, although NaF or phorbol 12-myristate 13-acetate did trigger GLUT4myc translocation in the cells.	Tetradecanoylphorbol Acetate	190-221	insulin receptor substrate 1	Rattus norvegicus	26-31
9737980-2	1998	We have investigated the effect of the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) on ACE activity and gene expression in human umbilical vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	66-97	angiotensin I converting enzyme	Homo sapiens	107-110
9733728-8	1998	Co-transfection of the hINV promoter with dominant negative forms of Ras, MEKK1, MEK1, MEK7, MEK3, p38/RK, and c-Jun inhibit the TPA-dependent increase.	Tetradecanoylphorbol Acetate	129-132	mitogen-activated protein kinase 1	Homo sapiens	99-102
9737980-2	1998	We have investigated the effect of the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) on ACE activity and gene expression in human umbilical vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	99-102	angiotensin I converting enzyme	Homo sapiens	107-110
9733728-8	1998	Co-transfection of the hINV promoter with dominant negative forms of Ras, MEKK1, MEK1, MEK7, MEK3, p38/RK, and c-Jun inhibit the TPA-dependent increase.	Tetradecanoylphorbol Acetate	129-132	mitogen-activated protein kinase kinase 7	Homo sapiens	87-91
9736697-1	1998	Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation.	Tetradecanoylphorbol Acetate	218-249	interleukin 6	Homo sapiens	56-69
9739171-2	1998	We investigated the effect of vitamin E on MIF production in macrophages in response to phorbol 12-myristate-13-acetate (PMA), calcium ionophore A23187, and lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	88-119	macrophage migration inhibitory factor	Rattus norvegicus	43-46
9739171-2	1998	We investigated the effect of vitamin E on MIF production in macrophages in response to phorbol 12-myristate-13-acetate (PMA), calcium ionophore A23187, and lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	121-124	macrophage migration inhibitory factor	Rattus norvegicus	43-46
9751075-5	1998	These observations suggest that 12-O-tetradecanoylphorbol-13-acetate-induced P-gp phosphorylation may be associated with induction of P-gp-mediated drug efflux in the HTB-123 cell line.	Tetradecanoylphorbol Acetate	32-68	ATP binding cassette subfamily B member 1	Homo sapiens	77-81
9751075-5	1998	These observations suggest that 12-O-tetradecanoylphorbol-13-acetate-induced P-gp phosphorylation may be associated with induction of P-gp-mediated drug efflux in the HTB-123 cell line.	Tetradecanoylphorbol Acetate	32-68	ATP binding cassette subfamily B member 1	Homo sapiens	134-138
9712149-4	1998	Protein kinase A activators, dibutyryl cyclic AMP, or forskolin had little or no effect, respectively, while phorbol 12-myristate 13-acetate (PMA), a PKC activator, increased TIMP-3 gene expression.	Tetradecanoylphorbol Acetate	109-140	TIMP metallopeptidase inhibitor 3	Bos taurus	175-181
9712149-4	1998	Protein kinase A activators, dibutyryl cyclic AMP, or forskolin had little or no effect, respectively, while phorbol 12-myristate 13-acetate (PMA), a PKC activator, increased TIMP-3 gene expression.	Tetradecanoylphorbol Acetate	142-145	TIMP metallopeptidase inhibitor 3	Bos taurus	175-181
9736697-1	1998	Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation.	Tetradecanoylphorbol Acetate	218-249	interleukin 6	Homo sapiens	71-75
9736697-1	1998	Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation.	Tetradecanoylphorbol Acetate	218-249	signal transducer and activator of transcription 3	Homo sapiens	102-107
9736697-1	1998	Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation.	Tetradecanoylphorbol Acetate	218-249	interleukin 6	Homo sapiens	268-272
9736697-1	1998	Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation.	Tetradecanoylphorbol Acetate	218-249	signal transducer and activator of transcription 3	Homo sapiens	281-286
9736697-1	1998	Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation.	Tetradecanoylphorbol Acetate	251-254	interleukin 6	Homo sapiens	56-69
9736697-1	1998	Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation.	Tetradecanoylphorbol Acetate	251-254	interleukin 6	Homo sapiens	71-75
9736697-1	1998	Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation.	Tetradecanoylphorbol Acetate	251-254	signal transducer and activator of transcription 3	Homo sapiens	102-107
9736697-1	1998	Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation.	Tetradecanoylphorbol Acetate	251-254	interleukin 6	Homo sapiens	268-272
9736697-1	1998	Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation.	Tetradecanoylphorbol Acetate	251-254	signal transducer and activator of transcription 3	Homo sapiens	281-286
9736697-4	1998	Inhibition of Stat3 DNA-binding activity and tyrosine phosphorylation by PMA, ionomycin, and granulocyte/macrophage-colony-stimulating factor was reversed when activation of the extracellular signal-regulated kinase (ERK) group of MAPKs was blocked by using specific kinase inhibitors.	Tetradecanoylphorbol Acetate	73-76	signal transducer and activator of transcription 3	Homo sapiens	14-19
9736697-4	1998	Inhibition of Stat3 DNA-binding activity and tyrosine phosphorylation by PMA, ionomycin, and granulocyte/macrophage-colony-stimulating factor was reversed when activation of the extracellular signal-regulated kinase (ERK) group of MAPKs was blocked by using specific kinase inhibitors.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase 1	Homo sapiens	178-215
9736697-4	1998	Inhibition of Stat3 DNA-binding activity and tyrosine phosphorylation by PMA, ionomycin, and granulocyte/macrophage-colony-stimulating factor was reversed when activation of the extracellular signal-regulated kinase (ERK) group of MAPKs was blocked by using specific kinase inhibitors.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase 1	Homo sapiens	217-220
9727032-6	1998	The epsilonV1-2 peptide blocked the inhibitory effect of TPA on both TNF-alpha- and calphostin C-induced apoptosis.	Tetradecanoylphorbol Acetate	57-60	tumor necrosis factor	Homo sapiens	69-78
9727032-8	1998	These results suggest that PKCepsilon is required for the protective effect of TPA in TNF-alpha- and calphostin C-induced apoptosis.	Tetradecanoylphorbol Acetate	79-82	tumor necrosis factor	Homo sapiens	86-95
9729508-1	1998	The addition of phorbol 12-myristate 13-acetate (PMA) to renal LLC-PK1-F+ cells caused a rapid decrease in the level of phosphoenolpyruvate carboxykinase (PCK) mRNA and reversed the stimulatory effects of exposure to acidic medium (pH 6.9, 10 mM HCO-3) or cAMP.	Tetradecanoylphorbol Acetate	16-47	pyruvate kinase L/R	Homo sapiens	67-70
9771965-4	1998	In the ML-1 human myeloblastic leukemia cell line, a rapid and sustained increase in phosphorylation of the extracellular signal-regulated kinase (ERK) members of the MAP kinase family was found to precede the increase in MCL1 expression produced by 12-O-tetradecanoylphorbol 13-acetate (TPA) or the microtubule-disrupting agents colchicine and vinblastine.	Tetradecanoylphorbol Acetate	250-286	mitogen-activated protein kinase 1	Homo sapiens	108-145
9771965-4	1998	In the ML-1 human myeloblastic leukemia cell line, a rapid and sustained increase in phosphorylation of the extracellular signal-regulated kinase (ERK) members of the MAP kinase family was found to precede the increase in MCL1 expression produced by 12-O-tetradecanoylphorbol 13-acetate (TPA) or the microtubule-disrupting agents colchicine and vinblastine.	Tetradecanoylphorbol Acetate	250-286	mitogen-activated protein kinase 1	Homo sapiens	147-150
9771965-4	1998	In the ML-1 human myeloblastic leukemia cell line, a rapid and sustained increase in phosphorylation of the extracellular signal-regulated kinase (ERK) members of the MAP kinase family was found to precede the increase in MCL1 expression produced by 12-O-tetradecanoylphorbol 13-acetate (TPA) or the microtubule-disrupting agents colchicine and vinblastine.	Tetradecanoylphorbol Acetate	288-291	mitogen-activated protein kinase 1	Homo sapiens	108-145
9771965-4	1998	In the ML-1 human myeloblastic leukemia cell line, a rapid and sustained increase in phosphorylation of the extracellular signal-regulated kinase (ERK) members of the MAP kinase family was found to precede the increase in MCL1 expression produced by 12-O-tetradecanoylphorbol 13-acetate (TPA) or the microtubule-disrupting agents colchicine and vinblastine.	Tetradecanoylphorbol Acetate	288-291	mitogen-activated protein kinase 1	Homo sapiens	147-150
9722539-6	1998	UTP, ionomycin, and phorbol ester (phorbol 12-myristate 13-acetate) increased MAP kinase activity and also promoted the tyrosine phosphorylation of RAFTK, the epidermal growth factor (EGF) receptor, SHC, and p120(cbl).	Tetradecanoylphorbol Acetate	35-66	bromodomain containing 8	Rattus norvegicus	208-212
9728056-2	1998	Eotaxin mRNA was induced by tumor necrosis factor-alpha (TNF-alpha; 0.1-100 ng/ml) and phorbol 12-myristate 13-acetate (PMA; 0.01-1 microM).	Tetradecanoylphorbol Acetate	87-118	C-C motif chemokine ligand 11	Homo sapiens	0-7
9728056-2	1998	Eotaxin mRNA was induced by tumor necrosis factor-alpha (TNF-alpha; 0.1-100 ng/ml) and phorbol 12-myristate 13-acetate (PMA; 0.01-1 microM).	Tetradecanoylphorbol Acetate	120-123	C-C motif chemokine ligand 11	Homo sapiens	0-7
9728056-3	1998	PMA-induced eotaxin mRNA expression was of greater magnitude and was maximal at a later time point than TNF-alpha-induced expression (16 h vs. 2 h after stimulation), which was consistent with eotaxin protein expression detected by immunocytochemistry.	Tetradecanoylphorbol Acetate	0-3	C-C motif chemokine ligand 11	Homo sapiens	12-19
9722545-8	1998	However, this "non-membrane" PKC activity was inhibited by the phorbol ester 4beta-12-O-tetradecanoylphorbol-13-acetate (TPA) and also by the fluorescent analog, SAPD, opposite to its effect on membrane-associated PKCalpha.	Tetradecanoylphorbol Acetate	121-124	protein kinase C alpha	Homo sapiens	29-32
9722545-8	1998	However, this "non-membrane" PKC activity was inhibited by the phorbol ester 4beta-12-O-tetradecanoylphorbol-13-acetate (TPA) and also by the fluorescent analog, SAPD, opposite to its effect on membrane-associated PKCalpha.	Tetradecanoylphorbol Acetate	121-124	protein kinase C alpha	Homo sapiens	214-222
9730868-4	1998	Stimulation of eosinophils with C5a (10(-7) M) increased adhesion measured at 30 min to unactivated NHBEC from 11.4 +/- 0.7 to 15.5 +/- 0.4% (n = 4), and this increase was CD18/ICAM-1-independent, whereas phorbolmyristate acetate (PMA) (10(-8) M)-induced adhesion (20.7 +/- 1.7%) was abolished by anti-CD18 and reduced by anti-ICAM-1.	Tetradecanoylphorbol Acetate	205-229	complement C5a receptor 1	Homo sapiens	32-35
9730868-4	1998	Stimulation of eosinophils with C5a (10(-7) M) increased adhesion measured at 30 min to unactivated NHBEC from 11.4 +/- 0.7 to 15.5 +/- 0.4% (n = 4), and this increase was CD18/ICAM-1-independent, whereas phorbolmyristate acetate (PMA) (10(-8) M)-induced adhesion (20.7 +/- 1.7%) was abolished by anti-CD18 and reduced by anti-ICAM-1.	Tetradecanoylphorbol Acetate	231-234	complement C5a receptor 1	Homo sapiens	32-35
9730868-5	1998	In contrast, C5a- and PMA-induced adhesion to TNF-alpha/IFN-gamma-activated NHBEC (increased from 11.1 +/- 1.3% to 21.9 +/- 1.0% and 27.6 +/- 1.9%, respectively) was CD18- and ICAM-1-dependent.	Tetradecanoylphorbol Acetate	22-25	tumor necrosis factor	Homo sapiens	46-55
9730868-5	1998	In contrast, C5a- and PMA-induced adhesion to TNF-alpha/IFN-gamma-activated NHBEC (increased from 11.1 +/- 1.3% to 21.9 +/- 1.0% and 27.6 +/- 1.9%, respectively) was CD18- and ICAM-1-dependent.	Tetradecanoylphorbol Acetate	22-25	interferon gamma	Homo sapiens	56-65
9728056-3	1998	PMA-induced eotaxin mRNA expression was of greater magnitude and was maximal at a later time point than TNF-alpha-induced expression (16 h vs. 2 h after stimulation), which was consistent with eotaxin protein expression detected by immunocytochemistry.	Tetradecanoylphorbol Acetate	0-3	C-C motif chemokine ligand 11	Homo sapiens	193-200
9729508-1	1998	The addition of phorbol 12-myristate 13-acetate (PMA) to renal LLC-PK1-F+ cells caused a rapid decrease in the level of phosphoenolpyruvate carboxykinase (PCK) mRNA and reversed the stimulatory effects of exposure to acidic medium (pH 6.9, 10 mM HCO-3) or cAMP.	Tetradecanoylphorbol Acetate	49-52	pyruvate kinase L/R	Homo sapiens	67-70
9737714-2	1998	A number of agents, including PMA, opsonized bacteria and zymosan, LPS, GM-CSF, TNF-alpha, and fMLP, induced COX-2 protein expression through signaling pathways involving transcription and protein synthesis events.	Tetradecanoylphorbol Acetate	30-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
9740146-10	1998	TPA (10 nmol/L) also stimulated the production of IL-6 and IL-8 by these cells, but inhibited that of monocyte chemoattractant protein-1.	Tetradecanoylphorbol Acetate	0-3	interleukin 6	Homo sapiens	50-54
9740146-10	1998	TPA (10 nmol/L) also stimulated the production of IL-6 and IL-8 by these cells, but inhibited that of monocyte chemoattractant protein-1.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
9762412-2	1998	Phorbol ester (PMA) activated endogenous and ectopically expressed PKC alpha, beta I, beta II, gamma, delta, epsilon, and eta.	Tetradecanoylphorbol Acetate	15-18	protein kinase C, alpha	Mus musculus	67-76
9724043-8	1998	As determined by hyperphosphorylation, tyrosine phosphorylation, and enzymatic activity, p42mapk and p44mapk were rapidly and transiently activated by both PGF2alpha (1 microM) and PMA (20 nM).	Tetradecanoylphorbol Acetate	181-184	mitogen-activated protein kinase 1	Bos taurus	89-96
9731575-6	1998	Co-incubation of Mahlavu cells with TGF-beta1 and 12-O-tetradecanoyl phorbol 13-acetate (TPA) decreased Src protein levels and Src kinase activity, inducing TGF-beta1 sensitivity.	Tetradecanoylphorbol Acetate	50-87	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	104-107
9789737-8	1998	A similar level of ERK2 activation was found in both young and older cells stimulated with phorbol-12-myristate-13-acetate (PMA), indicating an age-related alteration of the plasma membrane.	Tetradecanoylphorbol Acetate	91-122	mitogen-activated protein kinase 1	Homo sapiens	19-23
9789737-8	1998	A similar level of ERK2 activation was found in both young and older cells stimulated with phorbol-12-myristate-13-acetate (PMA), indicating an age-related alteration of the plasma membrane.	Tetradecanoylphorbol Acetate	124-127	mitogen-activated protein kinase 1	Homo sapiens	19-23
9731575-6	1998	Co-incubation of Mahlavu cells with TGF-beta1 and 12-O-tetradecanoyl phorbol 13-acetate (TPA) decreased Src protein levels and Src kinase activity, inducing TGF-beta1 sensitivity.	Tetradecanoylphorbol Acetate	50-87	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	127-130
9731575-6	1998	Co-incubation of Mahlavu cells with TGF-beta1 and 12-O-tetradecanoyl phorbol 13-acetate (TPA) decreased Src protein levels and Src kinase activity, inducing TGF-beta1 sensitivity.	Tetradecanoylphorbol Acetate	50-87	transforming growth factor beta 1	Homo sapiens	157-166
9731575-6	1998	Co-incubation of Mahlavu cells with TGF-beta1 and 12-O-tetradecanoyl phorbol 13-acetate (TPA) decreased Src protein levels and Src kinase activity, inducing TGF-beta1 sensitivity.	Tetradecanoylphorbol Acetate	89-92	transforming growth factor beta 1	Homo sapiens	36-45
9806262-7	1998	Luteal cells were then incubated for 24 h with phorbol 12-myristate-13 acetate (PMA) (100 ng/ml), an activator of protein kinase C. Inhibition of progesterone synthesis by PMA was similar to that induced by ET-1 alone.	Tetradecanoylphorbol Acetate	80-83	endothelin 1	Homo sapiens	207-211
9731575-6	1998	Co-incubation of Mahlavu cells with TGF-beta1 and 12-O-tetradecanoyl phorbol 13-acetate (TPA) decreased Src protein levels and Src kinase activity, inducing TGF-beta1 sensitivity.	Tetradecanoylphorbol Acetate	89-92	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	104-107
9731575-6	1998	Co-incubation of Mahlavu cells with TGF-beta1 and 12-O-tetradecanoyl phorbol 13-acetate (TPA) decreased Src protein levels and Src kinase activity, inducing TGF-beta1 sensitivity.	Tetradecanoylphorbol Acetate	89-92	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	127-130
9731575-6	1998	Co-incubation of Mahlavu cells with TGF-beta1 and 12-O-tetradecanoyl phorbol 13-acetate (TPA) decreased Src protein levels and Src kinase activity, inducing TGF-beta1 sensitivity.	Tetradecanoylphorbol Acetate	89-92	transforming growth factor beta 1	Homo sapiens	157-166
9699515-5	1998	Down regulation of protein kinase C (PKC) by pretreatment for 24 hours with 500 nm PMA prevents induction by subsequent stimulation with either PMA or NGA.	Tetradecanoylphorbol Acetate	83-86	protein kinase C alpha	Homo sapiens	37-40
9706871-4	1998	Sphingosine inhibited the IL-6 synthesis induced by PGF2alpha or 12-O-tetradecanoylphorbol-13-acetate, an activator of PKC.	Tetradecanoylphorbol Acetate	65-101	interleukin 6	Mus musculus	26-30
9706865-4	1998	To characterize these relationships further, we examined the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA), which downregulates ERalpha, and the high-affinity AhR ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), on the expression of AhR, ERalpha, CYP1A1, and CYP1B1 in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	110-113	estrogen receptor 1	Homo sapiens	136-143
9706865-5	1998	Treatment with TPA, which suppressed ERalpha mRNA levels, caused a greater than fourfold elevation of AhR mRNA and protein levels, whereas treatment with TCDD caused a decrease in AhR protein but no change in ERalpha or AhR mRNA levels.	Tetradecanoylphorbol Acetate	15-18	estrogen receptor 1	Homo sapiens	37-44
9706865-6	1998	In MCF-7 cells treated with TPA prior to treatment with TCDD, the AhR mRNA level was elevated, the ERalpha mRNA level remained suppressed, and the ratio of CYP1B1 to CYP1A1 mRNA was increased compared with treatment with TCDD alone.	Tetradecanoylphorbol Acetate	28-31	estrogen receptor 1	Homo sapiens	99-106
9699515-5	1998	Down regulation of protein kinase C (PKC) by pretreatment for 24 hours with 500 nm PMA prevents induction by subsequent stimulation with either PMA or NGA.	Tetradecanoylphorbol Acetate	144-147	protein kinase C alpha	Homo sapiens	37-40
9721728-9	1998	Significant decreases in PAR-1 expression were induced by the protein kinase C activator phorbol 12-myristate 13-acetate (87% at 3 h), the phospholipid inflammatory mediator lysophosphatidic acid (32% at 3 h), and the injury-related condition hypoglycemia (64 and 100% at 24 h in the absence and presence of dibutyryl cyclic AMP, respectively).	Tetradecanoylphorbol Acetate	89-120	coagulation factor II thrombin receptor	Homo sapiens	25-30
9848115-1	1998	Oleanolic acid (OA) has been shown to inhibit mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	76-112	promotion susceptibility QTL 1	Mus musculus	114-117
9868866-1	1998	The correlation between ornithine decarboxylase (ODC) protein induction and specific protein kinase C (PKC) isozyme expression by gamma-ray in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated normal and v-rasHa transformed mouse keratinocytes was examined.	Tetradecanoylphorbol Acetate	143-179	protein kinase C, alpha	Mus musculus	103-106
9868866-1	1998	The correlation between ornithine decarboxylase (ODC) protein induction and specific protein kinase C (PKC) isozyme expression by gamma-ray in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated normal and v-rasHa transformed mouse keratinocytes was examined.	Tetradecanoylphorbol Acetate	181-184	protein kinase C, alpha	Mus musculus	103-106
9868866-8	1998	These results indicate that PKC alpha as an important regulator of mouse epidermal changes by gamma-radiation, contributes to the ODC expression occurring during exposure to tumor promoter, such as TPA, and epidermal neoplasia induced by ras activation.	Tetradecanoylphorbol Acetate	198-201	protein kinase C, alpha	Mus musculus	28-37
9743209-5	1998	In activated T cells toremifene clearly inhibits phorbol 12-myristate 13-acetate (PMA)-induced JNK activity, suggesting that the JNK pathway may also be involved in the up-regulation of TNF-R2 expression by antioestrogens.	Tetradecanoylphorbol Acetate	49-80	mitogen-activated protein kinase 8	Homo sapiens	95-98
9743209-5	1998	In activated T cells toremifene clearly inhibits phorbol 12-myristate 13-acetate (PMA)-induced JNK activity, suggesting that the JNK pathway may also be involved in the up-regulation of TNF-R2 expression by antioestrogens.	Tetradecanoylphorbol Acetate	49-80	mitogen-activated protein kinase 8	Homo sapiens	129-132
9743209-5	1998	In activated T cells toremifene clearly inhibits phorbol 12-myristate 13-acetate (PMA)-induced JNK activity, suggesting that the JNK pathway may also be involved in the up-regulation of TNF-R2 expression by antioestrogens.	Tetradecanoylphorbol Acetate	82-85	mitogen-activated protein kinase 8	Homo sapiens	95-98
9743209-5	1998	In activated T cells toremifene clearly inhibits phorbol 12-myristate 13-acetate (PMA)-induced JNK activity, suggesting that the JNK pathway may also be involved in the up-regulation of TNF-R2 expression by antioestrogens.	Tetradecanoylphorbol Acetate	82-85	mitogen-activated protein kinase 8	Homo sapiens	129-132
9769128-0	1998	TPA-induced cohort migration of well-differentiated human rectal adenocarcinoma cells: cells move in a RGD-dependent manner on fibronectin produced by cells, and phosphorylation of E-cadherin/catenin complex is induced independently of cell-extracellular matrix interactions.	Tetradecanoylphorbol Acetate	0-3	fibronectin 1	Homo sapiens	127-138
9769128-0	1998	TPA-induced cohort migration of well-differentiated human rectal adenocarcinoma cells: cells move in a RGD-dependent manner on fibronectin produced by cells, and phosphorylation of E-cadherin/catenin complex is induced independently of cell-extracellular matrix interactions.	Tetradecanoylphorbol Acetate	0-3	cadherin 1	Homo sapiens	181-191
9712916-17	1998	Treatment of the NIH 3T3 cells with specific cytokines (i.e. interleukin-6) and other agonists (i.e. lipopolysaccharide) caused a substantially increased level of 125I-UG binding but the same cells, when treated with platelet-derived growth factor, tumor necrosis factor-alpha, interferon-gamma, and phorbol 12-myristate 13-acetate, did not alter the UG binding.	Tetradecanoylphorbol Acetate	300-331	interleukin 6	Mus musculus	61-74
9806357-5	1998	Activation of PKC by phorbol myristate acetate (PMA) stimulated MAP kinase activity, and down-regulation of PKC completely prevented apo A-I-stimulation of MAP kinase activity.	Tetradecanoylphorbol Acetate	48-51	apolipoprotein A1	Homo sapiens	133-140
9705326-1	1998	We determined whether resveratrol, a phenolic antioxidant found in grapes and other food products, inhibited phorbol ester (PMA)-mediated induction of COX-2 in human mammary and oral epithelial cells.	Tetradecanoylphorbol Acetate	124-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
9705326-6	1998	PMA caused about a 6-fold increase in COX-2 promoter activity, which was suppressed by resveratrol.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
9705326-7	1998	Transient transfections utilizing COX-2 promoter deletion constructs and COX-2 promoter constructs, in which specific enhancer elements were mutagenized, indicated that the effects of PMA and resveratrol were mediated via a cyclic AMP response element.	Tetradecanoylphorbol Acetate	184-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
9705326-8	1998	Resveratrol inhibited PMA-mediated activation of protein kinase C. Overexpressing protein kinase C-alpha, ERK1, and c-Jun led to 4.7-, 5.1-, and 4-fold increases in COX-2 promoter activity, respectively.	Tetradecanoylphorbol Acetate	22-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	165-170
9700101-7	1998	Therefore, we also evaluated activation of the MAP kinase extracellular signal-regulated kinase (ERK) 2 by the phorbol ester phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	125-156	mitogen-activated protein kinase 1	Homo sapiens	58-103
9694709-1	1998	The expression of protein kinase C (PKC) isozymes in human basophils and the regulation of PKC isozymes during basophil activation by phorbol 12-myristate 13-acetate (PMA) +/- ionomycin, f-met-leu-phe (FMLP), and anti-IgE antibody were examined.	Tetradecanoylphorbol Acetate	134-165	protein kinase C alpha	Homo sapiens	91-94
9694709-1	1998	The expression of protein kinase C (PKC) isozymes in human basophils and the regulation of PKC isozymes during basophil activation by phorbol 12-myristate 13-acetate (PMA) +/- ionomycin, f-met-leu-phe (FMLP), and anti-IgE antibody were examined.	Tetradecanoylphorbol Acetate	167-170	protein kinase C alpha	Homo sapiens	91-94
9694709-6	1998	Within 1 minute of stimulation with PMA, 90% +/- 6% of PKC was found in the membrane fraction, however, no translocation of PKCdelta was apparent.	Tetradecanoylphorbol Acetate	36-39	protein kinase C alpha	Homo sapiens	55-58
9700101-7	1998	Therefore, we also evaluated activation of the MAP kinase extracellular signal-regulated kinase (ERK) 2 by the phorbol ester phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	158-161	mitogen-activated protein kinase 1	Homo sapiens	58-103
9716023-7	1998	Protein kinase C activation by phorbol 12-myristate 13-acetate up-regulated Wnt5a partly through prolongation of Wnt5a mRNA half-life.	Tetradecanoylphorbol Acetate	31-62	Wnt family member 5A	Homo sapiens	76-81
9683456-6	1998	The phorbol ester phorbol 12-myristate 13-acetate (PMA) inhibited ET-1 production.	Tetradecanoylphorbol Acetate	18-49	endothelin 1	Homo sapiens	66-70
9683456-6	1998	The phorbol ester phorbol 12-myristate 13-acetate (PMA) inhibited ET-1 production.	Tetradecanoylphorbol Acetate	51-54	endothelin 1	Homo sapiens	66-70
9683456-7	1998	Downregulation of protein kinase C (PKC) with PMA (1 microM) preincubation potentiated OSM-induced ET-1 production.	Tetradecanoylphorbol Acetate	46-49	endothelin 1	Homo sapiens	99-103
9688609-4	1998	Overexpression of PKC-delta produced subconfluent and confluent epithelial morphologies similar to that observed on exposure of wild-type cells to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	165-201	PRKCD	Sus scrofa	18-27
9688609-9	1998	As with LLC-PK1 cell sheets treated with 12-O-tetradecanoylphorbol-13-acetate, the reduced RT, increased D-mannitol flux, and tight junctional leakiness to ruthenium red that are seen with PKC-delta overexpression suggest the involvement of PKC-delta in regulation of tight junctional permeability.	Tetradecanoylphorbol Acetate	41-77	PRKCD	Sus scrofa	189-198
9716023-7	1998	Protein kinase C activation by phorbol 12-myristate 13-acetate up-regulated Wnt5a partly through prolongation of Wnt5a mRNA half-life.	Tetradecanoylphorbol Acetate	31-62	Wnt family member 5A	Homo sapiens	113-118
9738919-5	1998	Treatments with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, mimicked the action of thrombin.	Tetradecanoylphorbol Acetate	16-47	protein kinase C, alpha	Mus musculus	75-78
9877233-3	1998	Similarly, insulin release induced by the phorbol ester TPA (protein kinase C activator) was markedly potentiated.	Tetradecanoylphorbol Acetate	56-59	insulin	Homo sapiens	11-18
9877233-11	1998	The pharmacological intracellular NO donor hydroxylamine dose-dependently inhibited insulin release stimulated by TPA.	Tetradecanoylphorbol Acetate	114-117	insulin	Homo sapiens	84-91
9619293-4	1998	The potentiation by TPA of the MgATP-dependent priming was blocked by [Ser25]protein kinase C(19-31), a specific substrate of protein kinase C. Go 6976, an inhibitor selective for protein kinase C alpha and beta isoforms, also blocked the potentiation by TPA.	Tetradecanoylphorbol Acetate	20-23	protein kinase C alpha	Homo sapiens	180-202
9710205-3	1998	When NF-kappaB was prestimulated by TNF-alpha or phorbol 12-myristate 13-acetate, the addition of NO at low concentrations enhanced the activation of NF-kappaB.	Tetradecanoylphorbol Acetate	49-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	5-14
9710205-3	1998	When NF-kappaB was prestimulated by TNF-alpha or phorbol 12-myristate 13-acetate, the addition of NO at low concentrations enhanced the activation of NF-kappaB.	Tetradecanoylphorbol Acetate	49-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	150-159
9683525-19	1998	This arrest, in turn, is associated with a shift of PKC isozymes PKC alpha, PKC betaI, PKC betaII, PKC delta, PKC epsilon, and PKC mu to the membrane fraction which is induced by addition of TPA.	Tetradecanoylphorbol Acetate	191-194	protein kinase C alpha	Homo sapiens	52-55
9767445-7	1998	This study has shown that, while rat CRP inhibited phorbol myristate acetate- (PMA) induced release of O- 2; by rat macrophages, CRP-treated macrophages released NO in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	51-76	C-reactive protein	Rattus norvegicus	37-40
9767445-7	1998	This study has shown that, while rat CRP inhibited phorbol myristate acetate- (PMA) induced release of O- 2; by rat macrophages, CRP-treated macrophages released NO in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	51-76	C-reactive protein	Rattus norvegicus	129-132
9767445-7	1998	This study has shown that, while rat CRP inhibited phorbol myristate acetate- (PMA) induced release of O- 2; by rat macrophages, CRP-treated macrophages released NO in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	79-82	C-reactive protein	Rattus norvegicus	37-40
9767445-7	1998	This study has shown that, while rat CRP inhibited phorbol myristate acetate- (PMA) induced release of O- 2; by rat macrophages, CRP-treated macrophages released NO in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	79-82	C-reactive protein	Rattus norvegicus	129-132
9686585-6	1998	In striking contrast, the H2O2 scavenger catalase completely prevented the PMA-stimulated T cell death, thereby revealing a potent mitogenic activity of PMA for human T cells in the presence of monocytes.	Tetradecanoylphorbol Acetate	75-78	catalase	Homo sapiens	41-49
9619293-9	1998	Calmodulin, which binds to GAP-43 and inhibits its phosphorylation by protein kinase C, abolished the effect of TPA.	Tetradecanoylphorbol Acetate	112-115	calmodulin 1	Homo sapiens	0-10
9683525-7	1998	Examination of the levels of cyclins A and B1 demonstrated that the levels of these cyclins were not limiting for entrance into M. However, the addition of TPA blocked the increase in p34(cdc2)/cyclin B1 kinase activity.	Tetradecanoylphorbol Acetate	156-159	cyclin A2	Homo sapiens	29-45
9683525-14	1998	PKC alpha, betaI, betaII, delta, and epsilon isozymes were translocated to the membrane fraction from the cytosolic fraction when treated with TPA.	Tetradecanoylphorbol Acetate	143-146	protein kinase C alpha	Homo sapiens	0-9
9754866-3	1998	TREATMENT: Cells were treated with TG, CPA, DTBHQ, DTAHQ and MTBHQ for 3 h in the presence of 12-Otetradecanoylphorbol-13-acetate (TPA) and released TNF-alpha from the cells was measured (n &gt; or = 4).	Tetradecanoylphorbol Acetate	94-129	tumor necrosis factor	Rattus norvegicus	149-158
9686602-7	1998	ERK activation was enhanced by C2-ceramide plus PMA stimulation, whereas the activation of JNK was aborted.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 1	Homo sapiens	0-3
9686602-8	1998	Strikingly, the inhibition of MEK with PD98059 altered the phenotype of C2-ceramide- and PMA-stimulated U937 cells to that of cells treated with C2-ceramide alone.	Tetradecanoylphorbol Acetate	89-92	mitogen-activated protein kinase kinase 7	Homo sapiens	30-33
9686602-11	1998	Importantly, during C2-ceramide and PMA costimulation, the JNK pathway is not simply blocked by ERK activation; rather, cross-talk between these MAP kinase pathways acts to simultaneously augment ERK activity and down-regulate JNK activity.	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase 8	Homo sapiens	59-62
9686602-11	1998	Importantly, during C2-ceramide and PMA costimulation, the JNK pathway is not simply blocked by ERK activation; rather, cross-talk between these MAP kinase pathways acts to simultaneously augment ERK activity and down-regulate JNK activity.	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase 1	Homo sapiens	96-99
9686602-11	1998	Importantly, during C2-ceramide and PMA costimulation, the JNK pathway is not simply blocked by ERK activation; rather, cross-talk between these MAP kinase pathways acts to simultaneously augment ERK activity and down-regulate JNK activity.	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase 1	Homo sapiens	196-199
9686602-11	1998	Importantly, during C2-ceramide and PMA costimulation, the JNK pathway is not simply blocked by ERK activation; rather, cross-talk between these MAP kinase pathways acts to simultaneously augment ERK activity and down-regulate JNK activity.	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase 8	Homo sapiens	227-230
9738919-5	1998	Treatments with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, mimicked the action of thrombin.	Tetradecanoylphorbol Acetate	16-47	coagulation factor II	Mus musculus	114-122
9738919-5	1998	Treatments with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, mimicked the action of thrombin.	Tetradecanoylphorbol Acetate	49-52	protein kinase C, alpha	Mus musculus	75-78
9738919-5	1998	Treatments with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, mimicked the action of thrombin.	Tetradecanoylphorbol Acetate	49-52	coagulation factor II	Mus musculus	114-122
9744516-4	1998	PMA also induced an increase in PKC beta and PKC alpha mRNA and protein.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	45-54
9715266-5	1998	PD inhibited LPS and phorbol myristate acetate (PMA)-stimulated ERK activation as demonstrated by immunoblots using anti-activated ERK antibodies.	Tetradecanoylphorbol Acetate	21-46	mitogen-activated protein kinase 1	Homo sapiens	64-67
9715266-5	1998	PD inhibited LPS and phorbol myristate acetate (PMA)-stimulated ERK activation as demonstrated by immunoblots using anti-activated ERK antibodies.	Tetradecanoylphorbol Acetate	21-46	mitogen-activated protein kinase 1	Homo sapiens	131-134
9715266-5	1998	PD inhibited LPS and phorbol myristate acetate (PMA)-stimulated ERK activation as demonstrated by immunoblots using anti-activated ERK antibodies.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 1	Homo sapiens	64-67
9715266-5	1998	PD inhibited LPS and phorbol myristate acetate (PMA)-stimulated ERK activation as demonstrated by immunoblots using anti-activated ERK antibodies.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 1	Homo sapiens	131-134
9744516-5	1998	Simultaneous exposure to PMA and sphingosine blocked stimulation of CD11b and PKC expression without affecting growth arrest and VDR down regulation.	Tetradecanoylphorbol Acetate	25-28	protein kinase C alpha	Homo sapiens	78-81
9697876-4	1998	Inducibility of c-kit receptors by SCF, IL-1beta, IL-2, IL-7, TGF-beta, TNF-alpha, PMA or calcium ionophore A23187 was studied by flow cytometry (FCM).	Tetradecanoylphorbol Acetate	83-86	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	16-21
9726816-8	1998	Although the transcription factors NFkappaB and AP-1 cooperatively decreased their DNA-binding activities to kappaB and 12-O-tetradecanoylphorbol-13-acetate-responsive elements, respectively, and p53 increased DNA-binding activity in the early stage but decreased it in the latter stage after treatment with PTDS, when the human Hep G2 cells were undergoing apoptosis.	Tetradecanoylphorbol Acetate	120-156	nuclear factor kappa B subunit 1	Homo sapiens	35-43
9671751-4	1998	Mutation of cis-elements within HS2 reveals that the tandem-binding sites for the hematopoietic-specific transcription factor NF-E2 are required for induction by TPA, and induction is conferred by expressing NF-E2 in an NF-E2-null cell line.	Tetradecanoylphorbol Acetate	162-165	nuclear factor, erythroid 2	Homo sapiens	126-131
9706147-3	1998	METHODS: SK-Hep cells were treated with the PKC activator phorbol 12-myristate 13-acetate (PMA) and the initial-rate transport of glutamine and other nutrients measured at specific times thereafter.	Tetradecanoylphorbol Acetate	58-89	proline rich transmembrane protein 2	Homo sapiens	44-47
9706147-8	1998	Chronic treatment with PMA (PKC depletion) inhibited SK-Hep growth, as did attenuation of System B0-mediated glutamine uptake with other B0 substrates.	Tetradecanoylphorbol Acetate	23-26	proline rich transmembrane protein 2	Homo sapiens	28-31
9668098-8	1998	Further mutational analysis revealed that full TPA induction required interplay between several regulatory elements with homology to Ets, AP-1, and CAATT/enhancer binding protein C/EBP sites.	Tetradecanoylphorbol Acetate	47-50	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-142
9668098-9	1998	In addition, deletion or mutation of a 10-base pair region juxtaposed to the AP-1 site dramatically increased TPA induced FGF-BP gene expression.	Tetradecanoylphorbol Acetate	110-113	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-81
9668098-11	1998	Gel shift analysis showed specific and TPA-inducible protein binding to the Ets, AP-1, and C/EBP sites.	Tetradecanoylphorbol Acetate	39-42	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	81-85
9703960-6	1998	p220 was phosphorylated on serine/threonine in PMA-stimulated Rat1 cells, and rPLD1 expressed in Sf9 cells was also serine/threonine phosphorylated in response to PMA treatment.	Tetradecanoylphorbol Acetate	47-50	Ral GTPase activating protein catalytic subunit alpha 2	Rattus norvegicus	0-4
9714554-6	1998	PKC accumulation at the plasma membrane was detected 5 min after exposure to 12-O-tetradecanoyl phorbol-13-acetate and increased with time, thus demonstrating activation of these PKCs.	Tetradecanoylphorbol Acetate	77-114	protein kinase C alpha	Homo sapiens	0-3
9671751-4	1998	Mutation of cis-elements within HS2 reveals that the tandem-binding sites for the hematopoietic-specific transcription factor NF-E2 are required for induction by TPA, and induction is conferred by expressing NF-E2 in an NF-E2-null cell line.	Tetradecanoylphorbol Acetate	162-165	nuclear factor, erythroid 2	Homo sapiens	208-213
9671751-4	1998	Mutation of cis-elements within HS2 reveals that the tandem-binding sites for the hematopoietic-specific transcription factor NF-E2 are required for induction by TPA, and induction is conferred by expressing NF-E2 in an NF-E2-null cell line.	Tetradecanoylphorbol Acetate	162-165	nuclear factor, erythroid 2	Homo sapiens	208-213
9670939-9	1998	The intracellular incorporation of Abs specific for c-Fos and c-Jun family members by scrape loading inhibited the production and intracellular accumulation of IL-2 within 6 h of costimulation with PMA/ionomycin, or costimulation by CD28 and CD3 ligation.	Tetradecanoylphorbol Acetate	198-201	interleukin 2	Homo sapiens	160-164
9667501-4	1998	Inhibition of PMA-induced ICAM-1 and VCAM-1 expression as well as PMA-induced adhesion of Jurkat T-cells to ECV cells by alpha-lipoate was dose dependent (50-250 microM).	Tetradecanoylphorbol Acetate	14-17	vascular cell adhesion molecule 1	Homo sapiens	37-43
9674706-4	1998	PMA treatment of the u-PAR-deficient OVCAR-3 ovarian cancer cells, which contain low JNK activities, resulted in a rapid (5 min) increase in JNK activity.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	85-88
9674701-3	1998	In this report, we show that curcumin inhibits JNK activation by various agonists including PMA plus ionomycin, anisomycin, UV-C, gamma radiation, TNF-alpha, and sodium orthovanadate.	Tetradecanoylphorbol Acetate	92-95	mitogen-activated protein kinase 8	Homo sapiens	47-50
9674706-4	1998	PMA treatment of the u-PAR-deficient OVCAR-3 ovarian cancer cells, which contain low JNK activities, resulted in a rapid (5 min) increase in JNK activity.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	141-144
9674701-4	1998	Although both JNK and ERK activation by phorbol 12-myristate 13-acetate (PMA) plus ionomycin were suppressed by curcumin, the JNK pathway was more sensitive.	Tetradecanoylphorbol Acetate	40-71	mitogen-activated protein kinase 8	Homo sapiens	14-17
9674701-4	1998	Although both JNK and ERK activation by phorbol 12-myristate 13-acetate (PMA) plus ionomycin were suppressed by curcumin, the JNK pathway was more sensitive.	Tetradecanoylphorbol Acetate	40-71	mitogen-activated protein kinase 1	Homo sapiens	22-25
9682002-6	1998	Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression.	Tetradecanoylphorbol Acetate	172-175	CD40 ligand	Homo sapiens	94-99
9674701-4	1998	Although both JNK and ERK activation by phorbol 12-myristate 13-acetate (PMA) plus ionomycin were suppressed by curcumin, the JNK pathway was more sensitive.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase 8	Homo sapiens	14-17
9674701-4	1998	Although both JNK and ERK activation by phorbol 12-myristate 13-acetate (PMA) plus ionomycin were suppressed by curcumin, the JNK pathway was more sensitive.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase 1	Homo sapiens	22-25
9682002-6	1998	Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression.	Tetradecanoylphorbol Acetate	172-175	interleukin 2	Homo sapiens	194-198
9682002-6	1998	Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression.	Tetradecanoylphorbol Acetate	172-175	interferon gamma	Homo sapiens	203-212
9688860-14	1998	PMA stimulated 27% more mucin release at 4.7 microM than at 10 nM Ca2+.	Tetradecanoylphorbol Acetate	0-3	carbonic anhydrase 2	Rattus norvegicus	66-69
9688860-12	1998	Permeabilized SPOC1 cells were exposed to PMA or 4alpha-phorbol at Ca2+ activities ranging from 10 nM to 10 microM.	Tetradecanoylphorbol Acetate	42-45	carbonic anhydrase 2	Rattus norvegicus	67-70
9675116-3	1998	In vitro stimulation of BAM with cadmium oxide-coated silica particles (LiC-CdO) resulted in characteristic time-dependent changes in 2D-PAGE spot patterns, that were similar to the effects induced by 4ss-phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	238-241	cysteine dioxygenase type 1	Bos taurus	76-79
9665460-7	1998	In addition, PPARgamma mRNA expression in U937 cells increased during phorbol 12-myristate 13 acetate-induced differentiation.	Tetradecanoylphorbol Acetate	70-101	peroxisome proliferator activated receptor gamma	Homo sapiens	13-22
9688860-13	1998	PMA, but not 4alpha-phorbol, increased mucin release at all Ca2+ activities tested: at 10 nM Ca2+ mucin release was 2.1-fold greater than control and at 4.7 microM Ca2+ mucin release was maximal (3.6-fold increase).	Tetradecanoylphorbol Acetate	0-3	carbonic anhydrase 2	Rattus norvegicus	60-63
9639562-8	1998	Cellular fractionation and immunocytochemical staining results demonstrated that both 10 nM and 1 microM PMA treatments induced a marked translocation of PKC-alpha from cytosol to membrane or nuclear fraction within 5-30 min.	Tetradecanoylphorbol Acetate	105-108	protein kinase C alpha	Homo sapiens	154-163
9688860-13	1998	PMA, but not 4alpha-phorbol, increased mucin release at all Ca2+ activities tested: at 10 nM Ca2+ mucin release was 2.1-fold greater than control and at 4.7 microM Ca2+ mucin release was maximal (3.6-fold increase).	Tetradecanoylphorbol Acetate	0-3	carbonic anhydrase 2	Rattus norvegicus	93-96
9688860-13	1998	PMA, but not 4alpha-phorbol, increased mucin release at all Ca2+ activities tested: at 10 nM Ca2+ mucin release was 2.1-fold greater than control and at 4.7 microM Ca2+ mucin release was maximal (3.6-fold increase).	Tetradecanoylphorbol Acetate	0-3	carbonic anhydrase 2	Rattus norvegicus	93-96
9689011-8	1998	Treatment with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA, 10(-8) M) reproduced the inhibitory effect of ATP on iNOS protein expression and nitrite inhibition (by 46.6 +/- 10.	Tetradecanoylphorbol Acetate	52-83	nitric oxide synthase 2	Rattus norvegicus	143-147
9689011-8	1998	Treatment with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA, 10(-8) M) reproduced the inhibitory effect of ATP on iNOS protein expression and nitrite inhibition (by 46.6 +/- 10.	Tetradecanoylphorbol Acetate	85-88	nitric oxide synthase 2	Rattus norvegicus	143-147
9689011-10	1998	The effect of ATP or PMA was reversed by the PKC inhibitors Ro-31-8220 (10(-8) M) and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (10(-5) M), indicating that suppression of iNOS is mediated via activation of PKC through stimulated P2Y2 receptors.	Tetradecanoylphorbol Acetate	21-24	nitric oxide synthase 2	Rattus norvegicus	176-180
9639562-10	1998	In addition, prolonged treatment with 1 microM PMA, but not with 10 nM PMA, selectively mediated the down-regulation of these three PKC isoenzymes.	Tetradecanoylphorbol Acetate	47-50	protein kinase C alpha	Homo sapiens	132-135
9632843-5	1998	When 1,25(OH)2D3 (10 nM) was added to PMA treatments, most PMA-induced changes, particularly its effects to up-regulate iNOS-dependent NO production and change cell morphology, were multiplicatively augmented.	Tetradecanoylphorbol Acetate	38-41	nitric oxide synthase 2	Homo sapiens	120-124
9719414-10	1998	ACE activity was increased 3-fold in cell and 1.5-fold in the culture medium of PMA-treated cells.	Tetradecanoylphorbol Acetate	80-83	angiotensin I converting enzyme	Homo sapiens	0-3
9692223-1	1998	The synthesis and tumor necrosis factor (TNF)-alpha production enhancing activity of substituted 3"-methylthalidomides on human leukemia cell line HL-60 stimulated with 12-O-tetradecanoyl-phorbol 13-acetate (TPA) are described.	Tetradecanoylphorbol Acetate	169-206	tumor necrosis factor	Homo sapiens	18-51
9692223-1	1998	The synthesis and tumor necrosis factor (TNF)-alpha production enhancing activity of substituted 3"-methylthalidomides on human leukemia cell line HL-60 stimulated with 12-O-tetradecanoyl-phorbol 13-acetate (TPA) are described.	Tetradecanoylphorbol Acetate	208-211	tumor necrosis factor	Homo sapiens	18-51
9632613-9	1998	Diminished binding in TPA-treated cells correlated with their reduced expression of sialyl Lewis x (CD15s), a putative cellular receptor component for HGE.	Tetradecanoylphorbol Acetate	22-25	fucosyltransferase 4	Homo sapiens	100-104
9679857-7	1998	RESULTS: The gene expression of IL-13 by HMC-1 cells and human lung mast cells, which was detected at a low level in an unstimulated condition, was increased by PMA/ionomycin and suppressed by dexamethasone.	Tetradecanoylphorbol Acetate	161-164	interleukin 13	Homo sapiens	32-37
9719414-11	1998	Analysis of ACE activity in intact monolayers and cell lysates of control and PMA-treated cells revealed that all enzymatically active ACE in PMA-treated cells is localized on the plasma membrane and acts as an ectoenzyme.	Tetradecanoylphorbol Acetate	78-81	angiotensin I converting enzyme	Homo sapiens	12-15
9719414-11	1998	Analysis of ACE activity in intact monolayers and cell lysates of control and PMA-treated cells revealed that all enzymatically active ACE in PMA-treated cells is localized on the plasma membrane and acts as an ectoenzyme.	Tetradecanoylphorbol Acetate	78-81	angiotensin I converting enzyme	Homo sapiens	135-138
9719414-11	1998	Analysis of ACE activity in intact monolayers and cell lysates of control and PMA-treated cells revealed that all enzymatically active ACE in PMA-treated cells is localized on the plasma membrane and acts as an ectoenzyme.	Tetradecanoylphorbol Acetate	142-145	angiotensin I converting enzyme	Homo sapiens	12-15
9719414-11	1998	Analysis of ACE activity in intact monolayers and cell lysates of control and PMA-treated cells revealed that all enzymatically active ACE in PMA-treated cells is localized on the plasma membrane and acts as an ectoenzyme.	Tetradecanoylphorbol Acetate	142-145	angiotensin I converting enzyme	Homo sapiens	135-138
9618150-6	1998	Cotransfection with dominant-negative p85 or with dominant-negative Ras also produced down-regulation of the insulin or IGF-I-induced 12-O-tetradecanoylphorbol-13-acetate response element (TRE)-CAT (five AP-1, activating protein-1, binding sites arranged in tandem) transactivation.	Tetradecanoylphorbol Acetate	134-170	insulin	Homo sapiens	109-116
9691223-4	1998	Second, the activations of both mitogen-activated protein (MAP) kinase and c-Jun N-terminal kinase (JNK) were attenuated in lpr DN cells upon direct activation by TPA/A23187.	Tetradecanoylphorbol Acetate	163-166	Fas (TNF receptor superfamily member 6)	Mus musculus	124-127
9618150-6	1998	Cotransfection with dominant-negative p85 or with dominant-negative Ras also produced down-regulation of the insulin or IGF-I-induced 12-O-tetradecanoylphorbol-13-acetate response element (TRE)-CAT (five AP-1, activating protein-1, binding sites arranged in tandem) transactivation.	Tetradecanoylphorbol Acetate	134-170	insulin like growth factor 1	Homo sapiens	120-125
9661070-7	1998	Among other potential agonists, phorbol myristate acetate (PMA) was a potent inducer of PGHS-2 expression, while forskolin (FSK), serum, and prostaglandins had little effect.	Tetradecanoylphorbol Acetate	32-57	prostaglandin-endoperoxide synthase 2	Homo sapiens	88-94
9661070-7	1998	Among other potential agonists, phorbol myristate acetate (PMA) was a potent inducer of PGHS-2 expression, while forskolin (FSK), serum, and prostaglandins had little effect.	Tetradecanoylphorbol Acetate	59-62	prostaglandin-endoperoxide synthase 2	Homo sapiens	88-94
9661070-9	1998	Twenty-four hours of PMA pretreatment blocked the induction of PGHS-2 by PMA but not by IL-1, suggesting that IL-1 induction of PGHS-2 mRNA is not dependent on the protein kinase C pathway.	Tetradecanoylphorbol Acetate	21-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	63-69
9661070-9	1998	Twenty-four hours of PMA pretreatment blocked the induction of PGHS-2 by PMA but not by IL-1, suggesting that IL-1 induction of PGHS-2 mRNA is not dependent on the protein kinase C pathway.	Tetradecanoylphorbol Acetate	21-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	128-134
9665201-5	1998	Whereas 12-O-tetradecanoylphorbol-13 acetate (TPA) increased both MMP-9 and TIMP-1 mRNA levels, tumor necrosis factor-alpha (TNF-alpha) stimulated only MMP-9 gene expression in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	8-44	TIMP metallopeptidase inhibitor 1	Homo sapiens	76-82
9648067-15	1998	In primary cultured peritoneal mesothelial cells, TGF-beta 1 also induced PAI-1 secretion and the shift of tPA toward high molecular weight complexes.	Tetradecanoylphorbol Acetate	107-110	transforming growth factor beta 1	Homo sapiens	50-60
9665201-5	1998	Whereas 12-O-tetradecanoylphorbol-13 acetate (TPA) increased both MMP-9 and TIMP-1 mRNA levels, tumor necrosis factor-alpha (TNF-alpha) stimulated only MMP-9 gene expression in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	46-49	TIMP metallopeptidase inhibitor 1	Homo sapiens	76-82
9665201-6	1998	Neutralizing monoclonal antibodies (MoABs) to TNF-alpha (anti-TNF-alpha) decreased the constitutive and TPA-dependent expression of MMP-9 but did not influence TIMP-1 expression, either in unstimulated or in TPA-treated NB4 cells.	Tetradecanoylphorbol Acetate	104-107	tumor necrosis factor	Homo sapiens	46-55
9665201-6	1998	Neutralizing monoclonal antibodies (MoABs) to TNF-alpha (anti-TNF-alpha) decreased the constitutive and TPA-dependent expression of MMP-9 but did not influence TIMP-1 expression, either in unstimulated or in TPA-treated NB4 cells.	Tetradecanoylphorbol Acetate	104-107	tumor necrosis factor	Homo sapiens	62-71
9658185-2	1998	Exposure of the cells to 4beta-phorbol-12-myristate-13-acetate (PMA), an activator PKC, resulted in a down-regulation of both beta1AR binding sites and mRNA levels in a time- and concentration-dependent manner.	Tetradecanoylphorbol Acetate	25-62	adrenoceptor beta 1	Rattus norvegicus	126-133
9665201-6	1998	Neutralizing monoclonal antibodies (MoABs) to TNF-alpha (anti-TNF-alpha) decreased the constitutive and TPA-dependent expression of MMP-9 but did not influence TIMP-1 expression, either in unstimulated or in TPA-treated NB4 cells.	Tetradecanoylphorbol Acetate	208-211	tumor necrosis factor	Homo sapiens	46-55
9658185-2	1998	Exposure of the cells to 4beta-phorbol-12-myristate-13-acetate (PMA), an activator PKC, resulted in a down-regulation of both beta1AR binding sites and mRNA levels in a time- and concentration-dependent manner.	Tetradecanoylphorbol Acetate	64-67	adrenoceptor beta 1	Rattus norvegicus	126-133
9680109-3	1998	They also show altered phosphorylation-dephosphorylation patterns of several proteins on stimulation with phorbol myristate acetate--a direct activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	106-131	proline rich transmembrane protein 2	Homo sapiens	155-171
9680109-3	1998	They also show altered phosphorylation-dephosphorylation patterns of several proteins on stimulation with phorbol myristate acetate--a direct activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	106-131	proline rich transmembrane protein 2	Homo sapiens	173-176
9684803-0	1998	Human thrombin and calcium bound factor Xa significantly shorten tPA-induced fibrin clot lysis time via neutralization of plasminogen activator inhibitor type 1 activity.	Tetradecanoylphorbol Acetate	65-68	coagulation factor II, thrombin	Homo sapiens	6-14
9594018-14	1998	We conclude that a PKC, likely of the novel type, nPKC, seems to be involved in PMA-induced reduction of expressed BSC1 and/or its ion transport function.	Tetradecanoylphorbol Acetate	80-83	brain size control 1	Mus musculus	115-119
9662335-4	1998	The protein kinase C activator phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA) also stimulated tyrosine phosphorylation of SHPS-1; however, down-regulation of protein kinase C by prolonged exposure of cells to TPA did not affect LAP-induced tyrosine phosphorylation of SHPS-1.	Tetradecanoylphorbol Acetate	46-82	signal-regulatory protein alpha	Mus musculus	133-139
9715512-5	1998	In the first study, a weak response (2/17 animals) was observed to the positive control 12-O-tetradecanoylphorbol 13-acetate (TPA in ethanol, 1.25 micrograms), and no response was observed to cyclophosphamide, phenolphthalein, or chlorpheniramine, despite evidence for skin penetration.	Tetradecanoylphorbol Acetate	88-124	promotion susceptibility QTL 1	Mus musculus	126-129
9648724-7	1998	Inhibition of protein kinase C by either calphostin C or phorbol 12-myristate 13-acetate downregulation inhibited the Ang II-induced tyrosine phosphorylation of p130Cas.	Tetradecanoylphorbol Acetate	57-88	angiotensinogen	Homo sapiens	118-124
9614119-1	1998	The phorbol ester phorbol 12-myristate 13-acetate induces remarkable phenotypic changes in intestinal HT-29 M6 cells; these changes consist of loss of homotypic adhesion and inactivation of E-cadherin.	Tetradecanoylphorbol Acetate	18-49	cadherin 1	Homo sapiens	190-200
9636198-5	1998	PPARgamma mRNA expression was also induced in primary macrophages and THP-1 monocytic leukemia cells by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	122-158	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
9636198-5	1998	PPARgamma mRNA expression was also induced in primary macrophages and THP-1 monocytic leukemia cells by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	122-158	GLI family zinc finger 2	Homo sapiens	70-75
9636198-5	1998	PPARgamma mRNA expression was also induced in primary macrophages and THP-1 monocytic leukemia cells by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	160-163	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
9636198-5	1998	PPARgamma mRNA expression was also induced in primary macrophages and THP-1 monocytic leukemia cells by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	160-163	GLI family zinc finger 2	Homo sapiens	70-75
9636198-6	1998	Inhibition of protein kinase C blocked the induction of PPARgamma expression by TPA, but not by oxLDL, suggesting that more than one signaling pathway regulates PPARgamma expression in macrophages.	Tetradecanoylphorbol Acetate	80-83	peroxisome proliferator activated receptor gamma	Homo sapiens	56-65
9636198-7	1998	TPA induced the expression of PPARgamma in RAW 264.7 macrophages by increasing transcription from the PPARgamma1 and PPARgamma3 promoters.	Tetradecanoylphorbol Acetate	0-3	peroxisome proliferator activated receptor gamma	Homo sapiens	30-39
9642110-3	1998	We have previously shown that moderate stimulation of CD4(+)CD8(+) thymocytes with a combination of the calcium ionophore ionomycin and phorbol myristate acetate mimics positive selection events including downregulation of CD8 expression.	Tetradecanoylphorbol Acetate	136-161	CD4 molecule	Homo sapiens	54-57
9662335-4	1998	The protein kinase C activator phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA) also stimulated tyrosine phosphorylation of SHPS-1; however, down-regulation of protein kinase C by prolonged exposure of cells to TPA did not affect LAP-induced tyrosine phosphorylation of SHPS-1.	Tetradecanoylphorbol Acetate	46-82	signal-regulatory protein alpha	Mus musculus	279-285
9662335-4	1998	The protein kinase C activator phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA) also stimulated tyrosine phosphorylation of SHPS-1; however, down-regulation of protein kinase C by prolonged exposure of cells to TPA did not affect LAP-induced tyrosine phosphorylation of SHPS-1.	Tetradecanoylphorbol Acetate	84-87	signal-regulatory protein alpha	Mus musculus	133-139
9662335-4	1998	The protein kinase C activator phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA) also stimulated tyrosine phosphorylation of SHPS-1; however, down-regulation of protein kinase C by prolonged exposure of cells to TPA did not affect LAP-induced tyrosine phosphorylation of SHPS-1.	Tetradecanoylphorbol Acetate	84-87	signal-regulatory protein alpha	Mus musculus	279-285
9662335-4	1998	The protein kinase C activator phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA) also stimulated tyrosine phosphorylation of SHPS-1; however, down-regulation of protein kinase C by prolonged exposure of cells to TPA did not affect LAP-induced tyrosine phosphorylation of SHPS-1.	Tetradecanoylphorbol Acetate	220-223	signal-regulatory protein alpha	Mus musculus	133-139
9674743-6	1998	In addition, phorbol 12-myristate 13-acetate (PMA) stimulated a loss of IL-6R from the cell surface, with a corresponding increase in the concentration of sIL-6R in the supernatant.	Tetradecanoylphorbol Acetate	13-44	interleukin 6 receptor	Homo sapiens	72-77
9601059-5	1998	PMA-stimulated PLD activity was blocked by the PKC inhibitor bisindolylmaleimide.	Tetradecanoylphorbol Acetate	0-3	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	15-18
9601059-5	1998	PMA-stimulated PLD activity was blocked by the PKC inhibitor bisindolylmaleimide.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	47-50
9674743-6	1998	In addition, phorbol 12-myristate 13-acetate (PMA) stimulated a loss of IL-6R from the cell surface, with a corresponding increase in the concentration of sIL-6R in the supernatant.	Tetradecanoylphorbol Acetate	46-49	interleukin 6 receptor	Homo sapiens	72-77
9593849-4	1998	In multidrug resistant MCF-7/MDR1 cells, which highly express PKC-alpha but lack the PtdCho-specific PLD activity, 100-nM PMA had relatively small stimulatory effects on the uptake of [14C]choline (approximately 1.5-fold) and [14C]PtdCho synthesis (1.5- to 2-fold).	Tetradecanoylphorbol Acetate	122-125	protein kinase C alpha	Homo sapiens	62-71
9606192-2	1998	These signals, which can be replaced by the pharmacological agents phorbol ester (PMA) and Ca2+ ionophore, synergistically activate the mitogen-activated protein kinase (MAPK) JNK.	Tetradecanoylphorbol Acetate	82-85	mitogen-activated protein kinase 8	Homo sapiens	176-179
9614208-5	1998	The response of prolactin mRNA to TGF-beta2 was inhibited by preincubation of cells with phorbol-12-myristate-13-acetate, which down-regulated protein kinase C (PKC).	Tetradecanoylphorbol Acetate	89-120	prolactin	Rattus norvegicus	16-25
9582362-4	1998	Selective depletion of cellular PKC-alpha and -delta, by 24 h of 12-O-tetradecanoylphorbol-13-acetate (TPA) exposure, reduced insulin degradation by 3-fold and similarly increased insulin retroendocytosis, with no change in PKC-zeta.	Tetradecanoylphorbol Acetate	65-101	protein kinase C, alpha	Mus musculus	32-52
9582362-4	1998	Selective depletion of cellular PKC-alpha and -delta, by 24 h of 12-O-tetradecanoylphorbol-13-acetate (TPA) exposure, reduced insulin degradation by 3-fold and similarly increased insulin retroendocytosis, with no change in PKC-zeta.	Tetradecanoylphorbol Acetate	103-106	protein kinase C, alpha	Mus musculus	32-52
9572476-9	1998	The addition of a pan-specific TGFbeta antibody to NRK cells treated with the 10-30 kD fraction of TPA-CM from PKCepsilon 30 cells blocked the ability of this material to stimulate thymidine incorporation.	Tetradecanoylphorbol Acetate	99-102	transforming growth factor, beta 1	Rattus norvegicus	31-38
9620661-3	1998	In fact, the secretion of IL-4 by basophils stimulated with ionomycin alone was down-regulated (30-70%) with the simultaneous addition of PMA.	Tetradecanoylphorbol Acetate	138-141	interleukin 4	Homo sapiens	26-30
9620661-4	1998	In peripheral blood lymphocytes (PBL), however, the combination of ionomycin and PMA were highly synergistic, resulting in maximum IL-4 release but at a slower rate.	Tetradecanoylphorbol Acetate	81-84	interleukin 4	Homo sapiens	131-135
9678716-4	1998	This spontaneous TNF-alpha synthesis was enhanced by phorbol ester (PMA) and phytohemagglutinin (PHA) and decreased by dexamethasone.	Tetradecanoylphorbol Acetate	68-71	tumor necrosis factor	Homo sapiens	17-26
9655251-4	1998	A single topical treatment of either 12-O-tetradecanoylphorbol-13-acetate (TPA) or chrysarobin or a single full-thickness wound induced the expression of HB-EGF and AR in mRNA samples isolated from whole mouse skin.	Tetradecanoylphorbol Acetate	37-73	amphiregulin	Mus musculus	165-167
9655251-4	1998	A single topical treatment of either 12-O-tetradecanoylphorbol-13-acetate (TPA) or chrysarobin or a single full-thickness wound induced the expression of HB-EGF and AR in mRNA samples isolated from whole mouse skin.	Tetradecanoylphorbol Acetate	75-78	amphiregulin	Mus musculus	165-167
9662758-4	1998	The PKC activator 12-o-tetradecanoyl-phorbol-13-acetate (TPA) was then administered intraarticularly.	Tetradecanoylphorbol Acetate	18-55	proline rich transmembrane protein 2	Homo sapiens	4-7
9662758-4	1998	The PKC activator 12-o-tetradecanoyl-phorbol-13-acetate (TPA) was then administered intraarticularly.	Tetradecanoylphorbol Acetate	57-60	proline rich transmembrane protein 2	Homo sapiens	4-7
9747655-3	1998	Dexamethasone suppressed IL-13 gene expression induced by stimulation with phytohemagglutinin and phorbol 12-myristate 13-acetate in a dose-dependent manner, with 96% suppression at 10(-6) M, and also suppressed the increased production of IL-13.	Tetradecanoylphorbol Acetate	98-129	interleukin 13	Homo sapiens	25-30
9593849-1	1998	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho).	Tetradecanoylphorbol Acetate	37-68	protein kinase C alpha	Homo sapiens	22-25
9593849-1	1998	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho).	Tetradecanoylphorbol Acetate	37-68	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	109-124
9593849-1	1998	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho).	Tetradecanoylphorbol Acetate	37-68	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-129
9593849-1	1998	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho).	Tetradecanoylphorbol Acetate	70-73	protein kinase C alpha	Homo sapiens	22-25
9593849-1	1998	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho).	Tetradecanoylphorbol Acetate	70-73	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	109-124
9593849-1	1998	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho).	Tetradecanoylphorbol Acetate	70-73	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-129
9593849-4	1998	In multidrug resistant MCF-7/MDR1 cells, which highly express PKC-alpha but lack the PtdCho-specific PLD activity, 100-nM PMA had relatively small stimulatory effects on the uptake of [14C]choline (approximately 1.5-fold) and [14C]PtdCho synthesis (1.5- to 2-fold).	Tetradecanoylphorbol Acetate	122-125	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	101-104
9593849-5	1998	In NIH 3T3 fibroblasts and MCF-7/PKC-alpha cells, both expressing PKC-alpha and PLD activities at high levels, 10-100-nM PMA enhanced [14C]choline uptake only slightly (1.7- to 2.2-fold), while it had much greater (approximately 4-9-fold) stimulatory effects on PtdCho synthesis.	Tetradecanoylphorbol Acetate	121-124	protein kinase C alpha	Homo sapiens	33-42
9593849-5	1998	In NIH 3T3 fibroblasts and MCF-7/PKC-alpha cells, both expressing PKC-alpha and PLD activities at high levels, 10-100-nM PMA enhanced [14C]choline uptake only slightly (1.7- to 2.2-fold), while it had much greater (approximately 4-9-fold) stimulatory effects on PtdCho synthesis.	Tetradecanoylphorbol Acetate	121-124	protein kinase C alpha	Homo sapiens	66-75
9593849-5	1998	In NIH 3T3 fibroblasts and MCF-7/PKC-alpha cells, both expressing PKC-alpha and PLD activities at high levels, 10-100-nM PMA enhanced [14C]choline uptake only slightly (1.7- to 2.2-fold), while it had much greater (approximately 4-9-fold) stimulatory effects on PtdCho synthesis.	Tetradecanoylphorbol Acetate	121-124	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	80-83
9593849-6	1998	PMA significantly enhanced the formation of phosphatidic acid (PtdOH) in MCF-7/PKC-alpha cells (2.8-fold increase), but not in MCF-7/MDR1 cells (1.4-fold increase), while in both cell lines it had only small (1.3-1.5-fold) stimulatory effects on 1,2-diacylglycerol (1, 2-DAG) formation.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	79-88
9565575-1	1998	Tumor necrosis factor-alpha (TNF-alpha) gene is one of the early response genes induced by phorbol 12-myristate 13-acetate (PMA) in human HL-60 myeloid leukemia cells.	Tetradecanoylphorbol Acetate	91-122	tumor necrosis factor	Homo sapiens	0-27
9605775-2	1998	Recent investigations showed that activation of PKC alpha by 12-O-tetradecanoylphorbol 13-acetate (TPA) induced apoptosis in LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	61-97	protein kinase C alpha	Homo sapiens	48-57
9605775-2	1998	Recent investigations showed that activation of PKC alpha by 12-O-tetradecanoylphorbol 13-acetate (TPA) induced apoptosis in LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	99-102	protein kinase C alpha	Homo sapiens	48-57
9627115-4	1998	Surprisingly, melanocytes from p16INK4A- or p21WAF1/CIP1-null mice remained TPA-dependent, and disruption of p21WAF1/CIP1 accelerated cell death in the absence of this mitogen.	Tetradecanoylphorbol Acetate	76-79	cyclin dependent kinase inhibitor 2A	Mus musculus	31-39
9565575-1	1998	Tumor necrosis factor-alpha (TNF-alpha) gene is one of the early response genes induced by phorbol 12-myristate 13-acetate (PMA) in human HL-60 myeloid leukemia cells.	Tetradecanoylphorbol Acetate	91-122	tumor necrosis factor	Homo sapiens	29-38
9565575-1	1998	Tumor necrosis factor-alpha (TNF-alpha) gene is one of the early response genes induced by phorbol 12-myristate 13-acetate (PMA) in human HL-60 myeloid leukemia cells.	Tetradecanoylphorbol Acetate	124-127	tumor necrosis factor	Homo sapiens	0-27
9565575-1	1998	Tumor necrosis factor-alpha (TNF-alpha) gene is one of the early response genes induced by phorbol 12-myristate 13-acetate (PMA) in human HL-60 myeloid leukemia cells.	Tetradecanoylphorbol Acetate	124-127	tumor necrosis factor	Homo sapiens	29-38
9565575-2	1998	In the present study, we examined the role of the TNF-alpha autocrine loop in PMA-induced macrophage differentiation and gene expression of 92- and 72-kDa gelatinases (MMP-9 and MMP-2).	Tetradecanoylphorbol Acetate	78-81	tumor necrosis factor	Homo sapiens	50-59
9565575-5	1998	Blocking the endogenous TNF-alpha activity with neutralizing anti-TNF-alpha antibodies abolished all these PMA-induced events with the exception of MMP-2 gene expression.	Tetradecanoylphorbol Acetate	107-110	tumor necrosis factor	Homo sapiens	24-33
9600088-2	1998	12-O-tetradecanoyl phorbol-13-acetate, TPA, has been demonstrated to mimic insulin actions in these cells.	Tetradecanoylphorbol Acetate	0-37	insulin	Homo sapiens	75-82
9565575-5	1998	Blocking the endogenous TNF-alpha activity with neutralizing anti-TNF-alpha antibodies abolished all these PMA-induced events with the exception of MMP-2 gene expression.	Tetradecanoylphorbol Acetate	107-110	tumor necrosis factor	Homo sapiens	66-75
9600088-2	1998	12-O-tetradecanoyl phorbol-13-acetate, TPA, has been demonstrated to mimic insulin actions in these cells.	Tetradecanoylphorbol Acetate	39-42	insulin	Homo sapiens	75-82
9565575-8	1998	However, anti-TNF-alpha antibodies blocked PMA-induced augmentation of both alpha5 and beta1 integrin gene expression without affecting the expression of the FN gene.	Tetradecanoylphorbol Acetate	43-46	tumor necrosis factor	Homo sapiens	14-23
9564828-1	1998	We have investigated the effects of GnRH (LHRH) and of the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate on stathmin phosphorylation in the gonadotrope alphaT3-1 cell line.	Tetradecanoylphorbol Acetate	92-128	stathmin 1	Mus musculus	132-140
9572838-6	1998	PTH/PTHrP receptor phosphorylation in ROS 17/2.8, COS-7, and LLCPK-1 cells was also stimulated with forskolin and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	114-139	parathyroid hormone	Rattus norvegicus	0-3
9572838-6	1998	PTH/PTHrP receptor phosphorylation in ROS 17/2.8, COS-7, and LLCPK-1 cells was also stimulated with forskolin and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	141-144	parathyroid hormone	Rattus norvegicus	0-3
9612216-7	1998	Furthermore, the effect of NPY on L-type channels was mimicked by the PKC activator phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	84-115	neuropeptide Y	Rattus norvegicus	27-30
9615391-9	1998	Co-administration of bryostatin 1 with PMA antagonized the latter"s differentiation-inducing capacity and anti-proliferative effects, actions that were accompanied by a reduction in PMA-mediated p21CIP1/WAF1 induction, CDK2 inhibition, pRb dephosphorylation, and c-Myc downregulation.	Tetradecanoylphorbol Acetate	39-42	cyclin dependent kinase inhibitor 1A	Homo sapiens	195-202
9615391-9	1998	Co-administration of bryostatin 1 with PMA antagonized the latter"s differentiation-inducing capacity and anti-proliferative effects, actions that were accompanied by a reduction in PMA-mediated p21CIP1/WAF1 induction, CDK2 inhibition, pRb dephosphorylation, and c-Myc downregulation.	Tetradecanoylphorbol Acetate	39-42	cyclin dependent kinase inhibitor 1A	Homo sapiens	203-207
9615391-9	1998	Co-administration of bryostatin 1 with PMA antagonized the latter"s differentiation-inducing capacity and anti-proliferative effects, actions that were accompanied by a reduction in PMA-mediated p21CIP1/WAF1 induction, CDK2 inhibition, pRb dephosphorylation, and c-Myc downregulation.	Tetradecanoylphorbol Acetate	182-185	cyclin dependent kinase inhibitor 1A	Homo sapiens	195-202
9615391-9	1998	Co-administration of bryostatin 1 with PMA antagonized the latter"s differentiation-inducing capacity and anti-proliferative effects, actions that were accompanied by a reduction in PMA-mediated p21CIP1/WAF1 induction, CDK2 inhibition, pRb dephosphorylation, and c-Myc downregulation.	Tetradecanoylphorbol Acetate	182-185	cyclin dependent kinase inhibitor 1A	Homo sapiens	203-207
9603451-0	1998	PMA/ionomycin induces Ig kappa 3" enhancer activity which is in part mediated by a unique NFAT transcription complex.	Tetradecanoylphorbol Acetate	0-3	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	90-94
9603452-6	1998	The use of anti-CD3 or phorbol 12-myristate 13-acetate with ionomycin as the primary stimulus, together with costimulation through either CD28 or CD2 using transfectants with the appropriate ligands, allowed us to demonstrate that the resistance of IFN-gamma production to inhibition by CsA required both CD3 and CD28 triggering.	Tetradecanoylphorbol Acetate	23-54	interferon gamma	Homo sapiens	249-258
9564828-3	1998	LHRH stimulated stathmin phosphorylation through a specific receptor in a dose- and time-dependent manner, and TPA induced a similar extensive stathmin phosphorylation.	Tetradecanoylphorbol Acetate	111-114	stathmin 1	Mus musculus	143-151
9603471-4	1998	In contrast, the phorbol 12-myristate 13-acetate (PMA)-induced IL-10 production and CD69 expression, and the ionomycin plus PMA-induced IL-2 production are not affected.	Tetradecanoylphorbol Acetate	124-127	interleukin 2	Homo sapiens	136-140
9589661-8	1998	The action of AII was reproduced and indeed exceeded by the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA; 10 nmol/L; 5.5-fold increase; P &lt; 0.05).	Tetradecanoylphorbol Acetate	87-123	angiotensinogen	Homo sapiens	14-17
9570757-2	1998	Since both agents also modulate gap junction (GJ)-mediated cell-cell communication, we have examined the effects of all-trans retinoic acid (RA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of alpha1 (Cx43) and beta2 (Cx26) connexins, the two major gap junction gene products in mature rat epidermis.	Tetradecanoylphorbol Acetate	149-185	gap junction protein, alpha 1	Rattus norvegicus	221-225
9654052-4	1998	In these cells, the processing and release of TNFalpha were augmented by phorbol 12-myristate 13-acetate (PMA), mediated through a protein kinase C (PKC) signalling pathway.	Tetradecanoylphorbol Acetate	73-104	tumor necrosis factor	Homo sapiens	46-54
9654052-4	1998	In these cells, the processing and release of TNFalpha were augmented by phorbol 12-myristate 13-acetate (PMA), mediated through a protein kinase C (PKC) signalling pathway.	Tetradecanoylphorbol Acetate	106-109	tumor necrosis factor	Homo sapiens	46-54
9576480-3	1998	We have examined the effect of PMA and hemin on the expression of the Kell blood group and CD10 antigens, two related proteins that belong to a family of membrane-bound neutral metalloendopeptidases.	Tetradecanoylphorbol Acetate	31-34	membrane metalloendopeptidase	Homo sapiens	91-95
9548562-10	1998	Ionomycin- and TPA-induced HB-EGF-AP secretion was not dependent on the presence of the proHB-EGF cytoplasmic domain and was specifically inhibited by the metalloproteinase inhibitors 1,10-phenanthroline and tissue inhibitor of metalloproteinase-1 (TIMP-1).	Tetradecanoylphorbol Acetate	15-18	TIMP metallopeptidase inhibitor 1	Homo sapiens	208-247
9548562-10	1998	Ionomycin- and TPA-induced HB-EGF-AP secretion was not dependent on the presence of the proHB-EGF cytoplasmic domain and was specifically inhibited by the metalloproteinase inhibitors 1,10-phenanthroline and tissue inhibitor of metalloproteinase-1 (TIMP-1).	Tetradecanoylphorbol Acetate	15-18	TIMP metallopeptidase inhibitor 1	Homo sapiens	249-255
9589661-8	1998	The action of AII was reproduced and indeed exceeded by the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA; 10 nmol/L; 5.5-fold increase; P &lt; 0.05).	Tetradecanoylphorbol Acetate	125-128	angiotensinogen	Homo sapiens	14-17
9620358-4	1998	After stimulation with anti-CD3 monoclonal antibody (mAb) OKT3 and phorbol myristate acetate (PMA), T cells from young humans exhibited severalfold increases in p53 protein expression compared with resting T cells.	Tetradecanoylphorbol Acetate	67-92	tumor protein p53	Homo sapiens	161-164
9581809-4	1998	Syk was found to be associated with Fc alphaR and its phosphorylation was increased in phorbol myristate acetate (PMA)- and interferon-gamma (IFN-gamma)-treated U937 cells.	Tetradecanoylphorbol Acetate	87-112	Fc alpha receptor	Homo sapiens	36-45
9581809-4	1998	Syk was found to be associated with Fc alphaR and its phosphorylation was increased in phorbol myristate acetate (PMA)- and interferon-gamma (IFN-gamma)-treated U937 cells.	Tetradecanoylphorbol Acetate	114-117	Fc alpha receptor	Homo sapiens	36-45
9620358-4	1998	After stimulation with anti-CD3 monoclonal antibody (mAb) OKT3 and phorbol myristate acetate (PMA), T cells from young humans exhibited severalfold increases in p53 protein expression compared with resting T cells.	Tetradecanoylphorbol Acetate	94-97	tumor protein p53	Homo sapiens	161-164
9620145-1	1998	PURPOSE: To identify the protein kinase C (PKC) isoforms in human arterial smooth muscle cells (SMC) and define their subcellular location in the resting state and in response to the PKC activator, 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	198-234	proline rich transmembrane protein 2	Homo sapiens	25-41
9620145-1	1998	PURPOSE: To identify the protein kinase C (PKC) isoforms in human arterial smooth muscle cells (SMC) and define their subcellular location in the resting state and in response to the PKC activator, 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	198-234	proline rich transmembrane protein 2	Homo sapiens	43-46
9652727-4	1998	TPA treatment arrested the cell cycle of a human hematopoietic cell line, MEG-01s, at the G1-S boundary and induced expression of p21/SDI1/WAF1/CIP1 and p27/KIP1.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	130-133
9620145-1	1998	PURPOSE: To identify the protein kinase C (PKC) isoforms in human arterial smooth muscle cells (SMC) and define their subcellular location in the resting state and in response to the PKC activator, 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	236-239	proline rich transmembrane protein 2	Homo sapiens	183-186
9652727-4	1998	TPA treatment arrested the cell cycle of a human hematopoietic cell line, MEG-01s, at the G1-S boundary and induced expression of p21/SDI1/WAF1/CIP1 and p27/KIP1.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	134-138
9652727-4	1998	TPA treatment arrested the cell cycle of a human hematopoietic cell line, MEG-01s, at the G1-S boundary and induced expression of p21/SDI1/WAF1/CIP1 and p27/KIP1.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	139-143
9652727-4	1998	TPA treatment arrested the cell cycle of a human hematopoietic cell line, MEG-01s, at the G1-S boundary and induced expression of p21/SDI1/WAF1/CIP1 and p27/KIP1.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	144-148
9566900-9	1998	U937 cells expressing ectopic wild-type c-Jun or TAM-67 secreted over threefold more TNF alpha than the control line in response to PMA plus lipopolysaccharide.	Tetradecanoylphorbol Acetate	132-135	tumor necrosis factor	Homo sapiens	85-94
9588200-4	1998	Phorbol-myristate-acetate (PMA) induced a rapid PKC translocation to and activation in the particulate cell fraction as determined by PKC-activity measurements and Western blots for PKC alpha.	Tetradecanoylphorbol Acetate	0-25	protein kinase C alpha	Homo sapiens	48-51
9583867-3	1998	METHODS: We determined the percentages of CD4+ and CD8+ lymphocytes producing IL-2 upon stimulation by phorbol myristate acetate and calcium ionophore in whole blood culture, using immunostaining of intracytoplasmatic and membrane markers, followed by multiparameter flow cytometry.	Tetradecanoylphorbol Acetate	103-128	interleukin 2	Homo sapiens	78-82
9584209-7	1998	Inactivation of PKC by incubation of the cells in the presence of 10 nM phorbol-12-myristate-13-acetate for 18 hr completely abolished the potentiating effect of thrombin on cyclase activity, whereas the pH-dependent stimulation was fully retained.	Tetradecanoylphorbol Acetate	72-103	coagulation factor II, thrombin	Homo sapiens	162-170
9588200-4	1998	Phorbol-myristate-acetate (PMA) induced a rapid PKC translocation to and activation in the particulate cell fraction as determined by PKC-activity measurements and Western blots for PKC alpha.	Tetradecanoylphorbol Acetate	0-25	protein kinase C alpha	Homo sapiens	134-137
9588200-4	1998	Phorbol-myristate-acetate (PMA) induced a rapid PKC translocation to and activation in the particulate cell fraction as determined by PKC-activity measurements and Western blots for PKC alpha.	Tetradecanoylphorbol Acetate	0-25	protein kinase C alpha	Homo sapiens	182-191
9588200-4	1998	Phorbol-myristate-acetate (PMA) induced a rapid PKC translocation to and activation in the particulate cell fraction as determined by PKC-activity measurements and Western blots for PKC alpha.	Tetradecanoylphorbol Acetate	27-30	protein kinase C alpha	Homo sapiens	48-51
9588200-4	1998	Phorbol-myristate-acetate (PMA) induced a rapid PKC translocation to and activation in the particulate cell fraction as determined by PKC-activity measurements and Western blots for PKC alpha.	Tetradecanoylphorbol Acetate	27-30	protein kinase C alpha	Homo sapiens	134-137
9588200-4	1998	Phorbol-myristate-acetate (PMA) induced a rapid PKC translocation to and activation in the particulate cell fraction as determined by PKC-activity measurements and Western blots for PKC alpha.	Tetradecanoylphorbol Acetate	27-30	protein kinase C alpha	Homo sapiens	182-191
9548924-6	1998	Analysis of the relaxation data indicates substantial chemical exchange for the adenosine residues in the UM TpA site, and this chemical exchange is quenched upon MAf formation.	Tetradecanoylphorbol Acetate	109-112	MAF bZIP transcription factor	Homo sapiens	163-166
9599015-3	1998	Retinoic acid exerted synergistic effects on AM secretion from THP-1 and HL-60 cells when administered with tumor necrosis factor-alpha, lipopolysaccharide or 12-O-tetradecanoyl phorbol-13-acetate.	Tetradecanoylphorbol Acetate	159-196	GLI family zinc finger 2	Homo sapiens	63-68
9553058-2	1998	We have identified a distal IL-2 enhancer regulated by the Raf-MEK-ERK signaling pathway, which can be induced by TPA/ionomycin treatment.	Tetradecanoylphorbol Acetate	114-117	interleukin 2	Homo sapiens	28-32
9553058-2	1998	We have identified a distal IL-2 enhancer regulated by the Raf-MEK-ERK signaling pathway, which can be induced by TPA/ionomycin treatment.	Tetradecanoylphorbol Acetate	114-117	mitogen-activated protein kinase kinase 7	Homo sapiens	63-66
9553058-2	1998	We have identified a distal IL-2 enhancer regulated by the Raf-MEK-ERK signaling pathway, which can be induced by TPA/ionomycin treatment.	Tetradecanoylphorbol Acetate	114-117	mitogen-activated protein kinase 1	Homo sapiens	67-70
9553058-4	1998	TPA/ionomycin treatment of T cells stimulates both mitogen-activated ERK, as well as the stress-activated mitogen-activated protein kinase family members JNK/SAPK and p38.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	69-72
9553058-4	1998	TPA/ionomycin treatment of T cells stimulates both mitogen-activated ERK, as well as the stress-activated mitogen-activated protein kinase family members JNK/SAPK and p38.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Homo sapiens	154-157
9553058-4	1998	TPA/ionomycin treatment of T cells stimulates both mitogen-activated ERK, as well as the stress-activated mitogen-activated protein kinase family members JNK/SAPK and p38.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 9	Homo sapiens	158-162
9553058-4	1998	TPA/ionomycin treatment of T cells stimulates both mitogen-activated ERK, as well as the stress-activated mitogen-activated protein kinase family members JNK/SAPK and p38.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Homo sapiens	167-170
9553058-7	1998	Furthermore, the JNK/SAPK signaling pathway cooperates with the Raf-MEK-ERK cascade in TPA/ionomycin-induced DSE activity.	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase 8	Homo sapiens	17-20
9553058-7	1998	Furthermore, the JNK/SAPK signaling pathway cooperates with the Raf-MEK-ERK cascade in TPA/ionomycin-induced DSE activity.	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase 9	Homo sapiens	21-25
9553058-7	1998	Furthermore, the JNK/SAPK signaling pathway cooperates with the Raf-MEK-ERK cascade in TPA/ionomycin-induced DSE activity.	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase kinase 7	Homo sapiens	68-71
9553058-7	1998	Furthermore, the JNK/SAPK signaling pathway cooperates with the Raf-MEK-ERK cascade in TPA/ionomycin-induced DSE activity.	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase 1	Homo sapiens	72-75
9553058-8	1998	In T cells, overexpression of SPRK/MLK3, an activator of JNK/SAPK, strongly induces DSE-dependent transcription and dominant negative kinases of SEK and SAPK impair TPA/ionomycin-induced DSE activity.	Tetradecanoylphorbol Acetate	165-168	mitogen-activated protein kinase 8	Homo sapiens	57-65
9553058-1	1998	T cell activation leads via multiple intracellular signaling pathways to rapid induction of interleukin-2 (IL-2) expression, which can be mimicked by costimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) and ionomycin.	Tetradecanoylphorbol Acetate	169-205	interleukin 2	Homo sapiens	92-105
9553058-1	1998	T cell activation leads via multiple intracellular signaling pathways to rapid induction of interleukin-2 (IL-2) expression, which can be mimicked by costimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) and ionomycin.	Tetradecanoylphorbol Acetate	169-205	interleukin 2	Homo sapiens	107-111
9553058-1	1998	T cell activation leads via multiple intracellular signaling pathways to rapid induction of interleukin-2 (IL-2) expression, which can be mimicked by costimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) and ionomycin.	Tetradecanoylphorbol Acetate	207-210	interleukin 2	Homo sapiens	92-105
9553058-1	1998	T cell activation leads via multiple intracellular signaling pathways to rapid induction of interleukin-2 (IL-2) expression, which can be mimicked by costimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) and ionomycin.	Tetradecanoylphorbol Acetate	207-210	interleukin 2	Homo sapiens	107-111
9508799-8	1998	In contrast, pretreatment with TPA reduced ICl(swell) in MDR1(G185V)-expressing transfected NIH3T3 fibroblasts.	Tetradecanoylphorbol Acetate	31-34	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	57-61
9535820-8	1998	Lastly, we observed that the use of the MEK1 inhibitor PD98059 inhibited TPA-mediated ERK activity and abrogated the anti-apoptotic effects of TPA.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase 1	Homo sapiens	86-89
9535820-10	1998	Therefore, we conclude that TPA inhibits the induction of apoptosis in anisomycin-treated HL-60 cells through an ERK-dependent pathway and that this effect can be reversed by the attenuation of ERK activity accompanied with the stimulation of JNK/SAPK activity.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 1	Homo sapiens	113-116
9535820-0	1998	Extracellular signal-regulated kinase (ERK) activity is required for TPA-mediated inhibition of drug-induced apoptosis.	Tetradecanoylphorbol Acetate	69-72	mitogen-activated protein kinase 1	Homo sapiens	0-37
9535820-0	1998	Extracellular signal-regulated kinase (ERK) activity is required for TPA-mediated inhibition of drug-induced apoptosis.	Tetradecanoylphorbol Acetate	69-72	mitogen-activated protein kinase 1	Homo sapiens	39-42
9535820-5	1998	We report the use of 12-O-tetradecanoylphorbol-13-acetate (TPA) in the inhibition of apoptosis in HL-60 cells stimulated with the JNK/SAPK activator anisomycin.	Tetradecanoylphorbol Acetate	21-57	mitogen-activated protein kinase 8	Homo sapiens	130-138
9535820-5	1998	We report the use of 12-O-tetradecanoylphorbol-13-acetate (TPA) in the inhibition of apoptosis in HL-60 cells stimulated with the JNK/SAPK activator anisomycin.	Tetradecanoylphorbol Acetate	59-62	mitogen-activated protein kinase 8	Homo sapiens	130-138
9535820-7	1998	Furthermore, the use of protein kinase C (PKC) inhibitors suggested that PKC was involved in the induction of ERK activity and in the inhibition of apoptosis by TPA since the inhibition of apoptosis was attenuated when cells were pretreated with PKC inhibitors.	Tetradecanoylphorbol Acetate	161-164	proline rich transmembrane protein 2	Homo sapiens	24-40
9535820-7	1998	Furthermore, the use of protein kinase C (PKC) inhibitors suggested that PKC was involved in the induction of ERK activity and in the inhibition of apoptosis by TPA since the inhibition of apoptosis was attenuated when cells were pretreated with PKC inhibitors.	Tetradecanoylphorbol Acetate	161-164	proline rich transmembrane protein 2	Homo sapiens	42-45
9535820-10	1998	Therefore, we conclude that TPA inhibits the induction of apoptosis in anisomycin-treated HL-60 cells through an ERK-dependent pathway and that this effect can be reversed by the attenuation of ERK activity accompanied with the stimulation of JNK/SAPK activity.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 1	Homo sapiens	194-197
9535820-7	1998	Furthermore, the use of protein kinase C (PKC) inhibitors suggested that PKC was involved in the induction of ERK activity and in the inhibition of apoptosis by TPA since the inhibition of apoptosis was attenuated when cells were pretreated with PKC inhibitors.	Tetradecanoylphorbol Acetate	161-164	proline rich transmembrane protein 2	Homo sapiens	73-76
9535820-7	1998	Furthermore, the use of protein kinase C (PKC) inhibitors suggested that PKC was involved in the induction of ERK activity and in the inhibition of apoptosis by TPA since the inhibition of apoptosis was attenuated when cells were pretreated with PKC inhibitors.	Tetradecanoylphorbol Acetate	161-164	mitogen-activated protein kinase 1	Homo sapiens	110-113
9535820-10	1998	Therefore, we conclude that TPA inhibits the induction of apoptosis in anisomycin-treated HL-60 cells through an ERK-dependent pathway and that this effect can be reversed by the attenuation of ERK activity accompanied with the stimulation of JNK/SAPK activity.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 8	Homo sapiens	243-246
9535820-7	1998	Furthermore, the use of protein kinase C (PKC) inhibitors suggested that PKC was involved in the induction of ERK activity and in the inhibition of apoptosis by TPA since the inhibition of apoptosis was attenuated when cells were pretreated with PKC inhibitors.	Tetradecanoylphorbol Acetate	161-164	proline rich transmembrane protein 2	Homo sapiens	73-76
9535820-10	1998	Therefore, we conclude that TPA inhibits the induction of apoptosis in anisomycin-treated HL-60 cells through an ERK-dependent pathway and that this effect can be reversed by the attenuation of ERK activity accompanied with the stimulation of JNK/SAPK activity.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 9	Homo sapiens	247-251
9525887-5	1998	The inhibitory activity of IL-8 was abolished by protein kinase C (PKC) inhibitors and was mimicked by the PKC activator 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	121-157	C-X-C motif chemokine ligand 8	Bos taurus	27-31
9582014-0	1998	In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter.	Tetradecanoylphorbol Acetate	58-61	protein kinase C, alpha	Mus musculus	75-78
9582014-4	1998	Further, the inhibition of melanogenesis by TPA results from a decrease of the tyrosinase promoter transcriptional activity and this effect is mimicked by over-expression of a constitutively active form of PKC alpha.	Tetradecanoylphorbol Acetate	44-47	protein kinase C, alpha	Mus musculus	206-215
9745617-8	1998	Western immunoblot analysis of cyclins (A, B1, D1 and E) and p27Kip1, a cyclin-dependent kinase inhibitor, indicated that TPA induced cyclin A and cyclin B1 expression in P+ (but not in P-) JB6 cells and this induction coincided in time with TPA-induced synthesis of DNA.	Tetradecanoylphorbol Acetate	122-125	cyclin A2	Homo sapiens	31-55
9582014-5	1998	These findings clearly demonstrate that PKC activation accounts for the inhibition of melanin synthesis by TPA.	Tetradecanoylphorbol Acetate	107-110	protein kinase C, alpha	Mus musculus	40-43
9582014-9	1998	Since microphthalmia, strongly stimulates the transcriptional activity of the promoter we propose that TPA, through PKC activation, decreases microphthalmia binding to the M-box of the tyrosinase promoter, thereby leading to a reduced tyrosinase expression and melanogenesis inhibition.	Tetradecanoylphorbol Acetate	103-106	protein kinase C, alpha	Mus musculus	116-119
9555862-7	1998	Phorbol 12-myristate 13-acetate, a potent activator of PKC, also augmented NF-kappaB activity in HUVECs, mimicking the effects of lysoPC; furthermore, calphostin C and chelerythrine chloride, specific PKC inhibitors, and alpha-tocopherol, a clinically potent PKC inhibitor, suppressed the lysoPC-induced NF-kappaB activation.	Tetradecanoylphorbol Acetate	0-31	nuclear factor kappa B subunit 1	Homo sapiens	75-84
9555862-7	1998	Phorbol 12-myristate 13-acetate, a potent activator of PKC, also augmented NF-kappaB activity in HUVECs, mimicking the effects of lysoPC; furthermore, calphostin C and chelerythrine chloride, specific PKC inhibitors, and alpha-tocopherol, a clinically potent PKC inhibitor, suppressed the lysoPC-induced NF-kappaB activation.	Tetradecanoylphorbol Acetate	0-31	nuclear factor kappa B subunit 1	Homo sapiens	304-313
9586564-4	1998	Moreover, regucalcin significantly inhibited phorbol 12-myristate 13-acetate (PMA)-increased protein kinase C activity.	Tetradecanoylphorbol Acetate	45-76	regucalcin	Rattus norvegicus	10-20
9586564-4	1998	Moreover, regucalcin significantly inhibited phorbol 12-myristate 13-acetate (PMA)-increased protein kinase C activity.	Tetradecanoylphorbol Acetate	78-81	regucalcin	Rattus norvegicus	10-20
9563854-1	1998	Phorbol ester-like protein kinase C (PKC) activators, such as 12-O-tetradecanoylphorbol-13-acetate, and perturbation of some growth factor receptors have been reported to alter the cytotoxicity of cis-diamminedichloroplatinum(II) (CDDP).	Tetradecanoylphorbol Acetate	62-98	protein kinase C alpha	Homo sapiens	37-40
9745617-8	1998	Western immunoblot analysis of cyclins (A, B1, D1 and E) and p27Kip1, a cyclin-dependent kinase inhibitor, indicated that TPA induced cyclin A and cyclin B1 expression in P+ (but not in P-) JB6 cells and this induction coincided in time with TPA-induced synthesis of DNA.	Tetradecanoylphorbol Acetate	122-125	cyclin A2	Homo sapiens	134-142
9565359-2	1998	Thus, phorbol 12-myristate 13-acetate (PMA) causes a PKC-dependent down-regulation of CD4 expression and induces apoptosis in isolated thymocytes but has little effect on thymocytes maintained within intact thymic lobes or in reaggregate lobes containing purified thymocytes with either thymic or non-thymic stromal cells.	Tetradecanoylphorbol Acetate	6-37	CD4 molecule	Homo sapiens	86-89
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	15-51	TIMP metallopeptidase inhibitor 1	Homo sapiens	88-94
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	15-51	plasminogen activator, urokinase	Homo sapiens	128-131
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	15-51	plasminogen activator, urokinase	Homo sapiens	150-153
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	53-56	TIMP metallopeptidase inhibitor 1	Homo sapiens	88-94
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	53-56	plasminogen activator, urokinase	Homo sapiens	128-131
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	53-56	plasminogen activator, urokinase	Homo sapiens	150-153
9528941-14	1998	On the other hand, dibutyryl cAMP suppressed PMA-stimulated expression of exon I.6 in THP-1 cells and adipose stromal cells.	Tetradecanoylphorbol Acetate	45-48	GLI family zinc finger 2	Homo sapiens	86-91
9528978-5	1998	We used a human monocytic leukemia cell line, THP-1, which differentiates into macrophages when treated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	109-140	GLI family zinc finger 2	Homo sapiens	46-51
9528978-6	1998	The coculture of EC and THP-1-derived macrophages enhanced CNP secretion by more than 10-fold compared with the single culture of EC or the coculture of EC and THP-1 without phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	174-205	GLI family zinc finger 2	Homo sapiens	24-29
9584910-4	1998	Furthermore, when the cells were treated simultaneously with a known protein kinase C (PKC) activator, phorbol 12-myristate-13-acetate (PMA) and TNFalpha in the presence of triclosan (0.5 microg/ml), the agent reduced the production of IL-1beta.	Tetradecanoylphorbol Acetate	103-134	interleukin 1 beta	Homo sapiens	236-244
9565359-2	1998	Thus, phorbol 12-myristate 13-acetate (PMA) causes a PKC-dependent down-regulation of CD4 expression and induces apoptosis in isolated thymocytes but has little effect on thymocytes maintained within intact thymic lobes or in reaggregate lobes containing purified thymocytes with either thymic or non-thymic stromal cells.	Tetradecanoylphorbol Acetate	39-42	CD4 molecule	Homo sapiens	86-89
9561912-10	1998	More significantly, they express constitutively the c-fms (the receptor of the macrophage growth factor) and, under TPA stimulation, are able to modulate the expression of this receptor and its ligand, as well as TNF-alpha and IL-1.	Tetradecanoylphorbol Acetate	116-119	tumor necrosis factor	Homo sapiens	213-222
9517568-6	1998	Ca2+ ionophore-A23187 and PKC activator-TPA mimicked the effects of these three agonists to stimulate AA release.	Tetradecanoylphorbol Acetate	40-43	protein kinase C alpha	Homo sapiens	26-29
9517568-12	1998	Similarly, ATP or TPA promoted AA release was inhibited by the mitogen-activated protein kinase (MAPK) cascade inhibitor PD 98059.	Tetradecanoylphorbol Acetate	18-21	mitogen-activated protein kinase 1	Homo sapiens	97-101
9517568-13	1998	ATP, TPA, or A23187 induced an increase in the activity and tyrosine phosphorylation of p42 MAPK, as well as a molecular weight shift, consistent with phosphorylation, of cytosolic phospholipase A2 (cPLA2).	Tetradecanoylphorbol Acetate	5-8	mitogen-activated protein kinase 1	Homo sapiens	88-96
9517568-14	1998	ATP- and TPA-stimulated activation of p42 MAPK activity and tyrosine phosphorylation were inhibited by long-term TPA treatment, while A23187-stimulated effects were completely blocked.	Tetradecanoylphorbol Acetate	9-12	cyclin dependent kinase like 1	Homo sapiens	38-41
9517568-14	1998	ATP- and TPA-stimulated activation of p42 MAPK activity and tyrosine phosphorylation were inhibited by long-term TPA treatment, while A23187-stimulated effects were completely blocked.	Tetradecanoylphorbol Acetate	9-12	mitogen-activated protein kinase 1	Homo sapiens	42-46
9517568-14	1998	ATP- and TPA-stimulated activation of p42 MAPK activity and tyrosine phosphorylation were inhibited by long-term TPA treatment, while A23187-stimulated effects were completely blocked.	Tetradecanoylphorbol Acetate	113-116	cyclin dependent kinase like 1	Homo sapiens	38-41
9517568-14	1998	ATP- and TPA-stimulated activation of p42 MAPK activity and tyrosine phosphorylation were inhibited by long-term TPA treatment, while A23187-stimulated effects were completely blocked.	Tetradecanoylphorbol Acetate	113-116	mitogen-activated protein kinase 1	Homo sapiens	42-46
9547349-8	1998	Phorbol myristate acetate inhibited both ET-18-OCH3-induced apoptosis and sustained JNK activation; thus, persistent JNK activation by ET-18-OCH3 is associated with the capacity of this ether phospholipid to induce apoptosis.	Tetradecanoylphorbol Acetate	0-25	mitogen-activated protein kinase 8	Homo sapiens	84-87
9547349-8	1998	Phorbol myristate acetate inhibited both ET-18-OCH3-induced apoptosis and sustained JNK activation; thus, persistent JNK activation by ET-18-OCH3 is associated with the capacity of this ether phospholipid to induce apoptosis.	Tetradecanoylphorbol Acetate	0-25	mitogen-activated protein kinase 8	Homo sapiens	117-120
9547352-1	1998	In primary human umbilical vein endothelial cells (HUVECs), incubation with phorbol-12-myristate-13-acetate (PMA) enhanced basal and bradykinin-stimulated nitric oxide production.	Tetradecanoylphorbol Acetate	76-107	kininogen 1	Homo sapiens	133-143
9547352-1	1998	In primary human umbilical vein endothelial cells (HUVECs), incubation with phorbol-12-myristate-13-acetate (PMA) enhanced basal and bradykinin-stimulated nitric oxide production.	Tetradecanoylphorbol Acetate	109-112	kininogen 1	Homo sapiens	133-143
9547352-9	1998	The time course of activation and down-regulation of these two PKC isoforms correlated well with the PMA-stimulated increase in NOS III expression.	Tetradecanoylphorbol Acetate	101-104	proline rich transmembrane protein 2	Homo sapiens	63-66
9547352-9	1998	The time course of activation and down-regulation of these two PKC isoforms correlated well with the PMA-stimulated increase in NOS III expression.	Tetradecanoylphorbol Acetate	101-104	nitric oxide synthase 3	Homo sapiens	128-135
9516439-6	1998	In contrast, PMA-induced PLD stimulation was inhibited by TcdB-1470 and TcsL in a time- and concentration-dependent manner, without alteration in immunologically detectable PKC isozyme levels.	Tetradecanoylphorbol Acetate	13-16	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	25-28
9620833-3	1998	Swim-up preparations of human spermatozoa were exposed to phorbol 12-myristate 13 acetate (PMA) and 1-oleoyl-2-acetyl-sn-glycerol (OAG), which are activators of PKC, and to dibutyryl cyclic AMP (dbcAMP), a PKA activator, and subsequently incubated with radiolabelled GABA.	Tetradecanoylphorbol Acetate	58-89	proline rich transmembrane protein 2	Homo sapiens	161-164
9523597-8	1998	These effects are compatible with (but likely not exclusively due to) an effect on the DNA binding of the 12-O-tetradecanoylphorbol 13-acetate response element to the AP-1 family of transcription factors.	Tetradecanoylphorbol Acetate	106-142	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-171
9516439-8	1998	In contrast, pretreatment with TcdB-1470 and TcsL, but not TcdB, strongly reduced PMA-stimulated PLD activity.	Tetradecanoylphorbol Acetate	82-85	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	97-100
9516474-6	1998	PMA also activates phospholipase D (PLD) in these cells and ethanol, a compound that inhibits PLD-mediated phosphatidic acid (PA) formation, blocked AA release.	Tetradecanoylphorbol Acetate	0-3	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	19-34
9516474-6	1998	PMA also activates phospholipase D (PLD) in these cells and ethanol, a compound that inhibits PLD-mediated phosphatidic acid (PA) formation, blocked AA release.	Tetradecanoylphorbol Acetate	0-3	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	36-39
9516474-6	1998	PMA also activates phospholipase D (PLD) in these cells and ethanol, a compound that inhibits PLD-mediated phosphatidic acid (PA) formation, blocked AA release.	Tetradecanoylphorbol Acetate	0-3	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	94-97
9600638-2	1998	Treatment with interferon-gamma (100 U/ml) or the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA) (16.2 nM) induced ICAM-1 expression.	Tetradecanoylphorbol Acetate	115-118	interferon gamma	Homo sapiens	15-31
9535722-1	1998	Here we analysed the involvement of tyrosine phosphorylation in the regulation of the initial molecular events induced by IL-13 to modulate TPA-triggered reactive oxygen intermediates (ROI) production.	Tetradecanoylphorbol Acetate	140-143	interleukin 13	Homo sapiens	122-127
9520415-5	1998	Three motifs, homologous to the binding sites of NF-kappaB, SP-1, and AP-1 proteins, contribute to induction of the MMP9 promoter by 12-O-tetradecanoyl-phorbol-13-acetate and tumor necrosis factor alpha.	Tetradecanoylphorbol Acetate	133-170	nuclear factor kappa B subunit 1	Homo sapiens	49-58
9524250-2	1998	This study investigated the molecular mechanism of transcriptional up-regulation of Cx26 by phorbol ester (TPA) in human immortalized MCF-10 mammary epithelial cells and MDA-MB-231 mammary cancer cells.	Tetradecanoylphorbol Acetate	107-110	gap junction protein beta 2	Homo sapiens	84-88
9600638-10	1998	These findings suggest that interferon-gamma induces ICAM-1 expression by a tyrosine kinase-dependent mechanism, but that TPA induces it by a protein kinase C- and NF-kappaB-dependent mechanism.	Tetradecanoylphorbol Acetate	122-125	nuclear factor kappa B subunit 1	Homo sapiens	164-173
9515796-4	1998	We found that inhibition of p38 by SB 203580 resulted in the almost complete reduction of phorbol myristate acetate-induced MMP-9 secretion but not of urokinase-type plasminogen activator secretion.	Tetradecanoylphorbol Acetate	90-115	mitogen-activated protein kinase 14	Homo sapiens	28-31
9490697-3	1998	Nef-expressing HMOs, treated with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA), overexpressed tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-10.	Tetradecanoylphorbol Acetate	62-93	S100 calcium binding protein B	Homo sapiens	0-3
9490697-3	1998	Nef-expressing HMOs, treated with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA), overexpressed tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-10.	Tetradecanoylphorbol Acetate	95-98	S100 calcium binding protein B	Homo sapiens	0-3
9515796-0	1998	Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.	Tetradecanoylphorbol Acetate	75-78	mitogen-activated protein kinase 14	Homo sapiens	18-21
9566710-1	1998	We have demonstrated previously that a phosphorothioate antisense oligonucleotide to the p65 subunit of the inducible transcription factor NF-kappaB produced rapid changes in the expression of leukocyte integrin CD11b (Mo 1) and in the adhesion of dimethylsulfoxide (DMSO)-differentiated HL-60 cells stimulated by 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	314-350	nuclear factor kappa B subunit 1	Homo sapiens	139-148
9514879-6	1998	The effects of 12-O-tetradecanoylphorbol beta-acetate (TPA) mimicked those of radiation on JNK cascade and 1-(5-isoquinolinesulphonyl)-2,5-dimethylpiperazine 2HCl (H7) and pretreatment with TPA blocked JNK activation following irradiation.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 8	Homo sapiens	91-94
9514932-1	1998	Incubation of the cells with phorbol myristate acetate increased the activity of endogenous and wild-type rPLD1.	Tetradecanoylphorbol Acetate	29-54	phospholipase D1	Rattus norvegicus	106-111
9514879-6	1998	The effects of 12-O-tetradecanoylphorbol beta-acetate (TPA) mimicked those of radiation on JNK cascade and 1-(5-isoquinolinesulphonyl)-2,5-dimethylpiperazine 2HCl (H7) and pretreatment with TPA blocked JNK activation following irradiation.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 8	Homo sapiens	202-205
9495244-3	1998	Modulation of PKC activity by treatment with a phorbol ester (TPA), drastically increased the invasiveness of 2 estrogen receptor-positive (ER+) lines (MCF7 and ZR 75.1), whereas it markedly decreased the invasiveness of 2 ER- cell lines (MDA-MB-231 and MDA-MB-435).	Tetradecanoylphorbol Acetate	62-65	proline rich transmembrane protein 2	Homo sapiens	14-17
9495244-4	1998	A PKC inhibitor (H7) reversed the TPA effects in MCF7 cells, whereas it mimicked TPA action in MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	34-37	proline rich transmembrane protein 2	Homo sapiens	2-5
9495244-8	1998	The opposed effects of TPA in ER+ and ER- cells could be due to the abnormal TPA regulation of PKCalpha observed in ER- cells.	Tetradecanoylphorbol Acetate	23-26	protein kinase C alpha	Homo sapiens	95-103
9495244-8	1998	The opposed effects of TPA in ER+ and ER- cells could be due to the abnormal TPA regulation of PKCalpha observed in ER- cells.	Tetradecanoylphorbol Acetate	77-80	protein kinase C alpha	Homo sapiens	95-103
9596483-6	1998	Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively.	Tetradecanoylphorbol Acetate	118-121	interleukin 1 beta	Homo sapiens	0-17
9530111-5	1998	Activation of p42mapk in HUVEC was also observed in response to TNF-alpha or to the protein kinase C (PKC)-activating phorbol ester phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	132-163	mitogen-activated protein kinase 1	Homo sapiens	14-21
9530111-5	1998	Activation of p42mapk in HUVEC was also observed in response to TNF-alpha or to the protein kinase C (PKC)-activating phorbol ester phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	165-168	mitogen-activated protein kinase 1	Homo sapiens	14-21
9504629-4	1998	Mitogenic stimulation with phorbol 12-myristate 13-acetate (PMA) or PMA plus interleukin-2 (IL-2) resulted in a tremendous increase in TNF-alpha and IL-6 production in cells representing early stage (Binet A) disease.	Tetradecanoylphorbol Acetate	27-58	tumor necrosis factor	Homo sapiens	135-144
9504629-4	1998	Mitogenic stimulation with phorbol 12-myristate 13-acetate (PMA) or PMA plus interleukin-2 (IL-2) resulted in a tremendous increase in TNF-alpha and IL-6 production in cells representing early stage (Binet A) disease.	Tetradecanoylphorbol Acetate	27-58	interleukin 6	Homo sapiens	149-153
9504629-4	1998	Mitogenic stimulation with phorbol 12-myristate 13-acetate (PMA) or PMA plus interleukin-2 (IL-2) resulted in a tremendous increase in TNF-alpha and IL-6 production in cells representing early stage (Binet A) disease.	Tetradecanoylphorbol Acetate	60-63	tumor necrosis factor	Homo sapiens	135-144
9504629-4	1998	Mitogenic stimulation with phorbol 12-myristate 13-acetate (PMA) or PMA plus interleukin-2 (IL-2) resulted in a tremendous increase in TNF-alpha and IL-6 production in cells representing early stage (Binet A) disease.	Tetradecanoylphorbol Acetate	60-63	interleukin 6	Homo sapiens	149-153
9504629-4	1998	Mitogenic stimulation with phorbol 12-myristate 13-acetate (PMA) or PMA plus interleukin-2 (IL-2) resulted in a tremendous increase in TNF-alpha and IL-6 production in cells representing early stage (Binet A) disease.	Tetradecanoylphorbol Acetate	68-71	tumor necrosis factor	Homo sapiens	135-144
9504629-4	1998	Mitogenic stimulation with phorbol 12-myristate 13-acetate (PMA) or PMA plus interleukin-2 (IL-2) resulted in a tremendous increase in TNF-alpha and IL-6 production in cells representing early stage (Binet A) disease.	Tetradecanoylphorbol Acetate	68-71	interleukin 6	Homo sapiens	149-153
9504629-7	1998	The most remarkable difference was recorded in PMA-stimulated (1 ng/ml) IL-6 production.	Tetradecanoylphorbol Acetate	47-50	interleukin 6	Homo sapiens	72-76
9607141-1	1998	Our previous results have demonstrated that phorbol 12-myristate 13-acetate (TPA) and insulin synergistically stimulate the activity of phosphatidylinositol-3 kinase (PI-3 kinase) and PI-3 kinase plays an important role in both of TPA-induced AP-1 activation and cell transformation in tumour promotion sensitive (P+) JB6 cells.	Tetradecanoylphorbol Acetate	231-234	insulin	Homo sapiens	86-93
9607141-2	1998	In the present study, we investigated the role of PKC and its isozymes in the synergistic induction of PI-3 kinase by TPA and insulin.	Tetradecanoylphorbol Acetate	118-121	protein kinase C alpha	Homo sapiens	50-53
9607141-3	1998	Bisindolylmaleimide inhibits TPA- and TPA+ insulin-induced PI-3 kinase activity.	Tetradecanoylphorbol Acetate	38-41	insulin	Homo sapiens	43-50
9607141-4	1998	Pretreatment of cells for 24 h with TPA has significant inhibitory effects on TPA-induced PI-3 kinase activity and abolishes the synergistic effect of TPA and insulin-stimulated PI-3 kinase activity.	Tetradecanoylphorbol Acetate	36-39	insulin	Homo sapiens	159-166
9607141-6	1998	These results indicate that the potentiation effect of TPA on insulin-induced PI-3 kinase activity is specific through PKC epsilon in JB6 cells.	Tetradecanoylphorbol Acetate	55-58	insulin	Homo sapiens	62-69
9542602-3	1998	In most patients, we found reduced frequencies of T cells recalled to express CD69 and the cytokines interleukin (IL)-4 and interferon-gamma (IFN-gamma) after stimulation of peripheral blood mononuclear cells with phorbol 12-myristate 13-acetate (PMA) and ionomycin, as compared with normal donors.	Tetradecanoylphorbol Acetate	214-245	interleukin 4	Homo sapiens	101-119
9542602-3	1998	In most patients, we found reduced frequencies of T cells recalled to express CD69 and the cytokines interleukin (IL)-4 and interferon-gamma (IFN-gamma) after stimulation of peripheral blood mononuclear cells with phorbol 12-myristate 13-acetate (PMA) and ionomycin, as compared with normal donors.	Tetradecanoylphorbol Acetate	214-245	interferon gamma	Homo sapiens	124-140
9542602-3	1998	In most patients, we found reduced frequencies of T cells recalled to express CD69 and the cytokines interleukin (IL)-4 and interferon-gamma (IFN-gamma) after stimulation of peripheral blood mononuclear cells with phorbol 12-myristate 13-acetate (PMA) and ionomycin, as compared with normal donors.	Tetradecanoylphorbol Acetate	214-245	interferon gamma	Homo sapiens	142-151
9542602-3	1998	In most patients, we found reduced frequencies of T cells recalled to express CD69 and the cytokines interleukin (IL)-4 and interferon-gamma (IFN-gamma) after stimulation of peripheral blood mononuclear cells with phorbol 12-myristate 13-acetate (PMA) and ionomycin, as compared with normal donors.	Tetradecanoylphorbol Acetate	247-250	interferon gamma	Homo sapiens	142-151
9596483-6	1998	Interleukin-1beta (IL-1beta) induced a tenfold and twofold synergistic increase in PGE2 production in the presence of TPA (10 nM) and bryostatin 1 (10 nM) respectively.	Tetradecanoylphorbol Acetate	118-121	interleukin 1 beta	Homo sapiens	19-27
9519739-1	1998	Under Ca2+-free conditions, activation of the pancreatic beta-cell with forskolin and 12-O-tetradecanoylphorbol 13-acetate (TPA) is permissive for the augmentation of insulin release by glucose and other nutrients.	Tetradecanoylphorbol Acetate	86-122	insulin	Homo sapiens	167-174
9533549-3	1998	Using RNA fingerprinting, we detected increased expression of Lerk-5 mRNA in human melanocytes as a response to the tumor-promoting drug 12-O-tetradecanoylphorbol-13-acetate, which suggests a possible role of the Lerks in melanoma tumorigenesis and progression.	Tetradecanoylphorbol Acetate	137-173	ephrin B2	Homo sapiens	62-68
9519739-1	1998	Under Ca2+-free conditions, activation of the pancreatic beta-cell with forskolin and 12-O-tetradecanoylphorbol 13-acetate (TPA) is permissive for the augmentation of insulin release by glucose and other nutrients.	Tetradecanoylphorbol Acetate	124-127	insulin	Homo sapiens	167-174
12014111-5	1998	To explore molecular mechanism that modulates bFGF release, we treated CNE-2 cells with PMA for two days and found that the treatment increased bFGF gene expression in the cytoplasm and bFGF release significantly after 48 hours.	Tetradecanoylphorbol Acetate	88-91	fibroblast growth factor 2	Homo sapiens	46-50
9492065-8	1998	T3 also inhibited IL-6 synthesis induced by 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C. On the other hand, T3 markedly enhanced IL-1-induced IL-6 synthesis.	Tetradecanoylphorbol Acetate	44-80	interleukin 6	Mus musculus	18-22
9640246-6	1998	T-cell proliferation mediated through CD6/CD28 was only partially blocked by the immunosuppressive drug, cyclosporin A (CsA), whereas anti-CD28-induced T-cell proliferation in the presence of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was unaffected.	Tetradecanoylphorbol Acetate	211-247	CD6 molecule	Homo sapiens	38-41
9640246-6	1998	T-cell proliferation mediated through CD6/CD28 was only partially blocked by the immunosuppressive drug, cyclosporin A (CsA), whereas anti-CD28-induced T-cell proliferation in the presence of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was unaffected.	Tetradecanoylphorbol Acetate	249-252	CD6 molecule	Homo sapiens	38-41
9543636-5	1998	RESULTS: A phorbol mitogen (TPA), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B, stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression; TIMP-2 levels are reduced by TNF but not affected by the other treatments.	Tetradecanoylphorbol Acetate	28-31	TIMP metallopeptidase inhibitor 1	Homo sapiens	156-162
9640246-7	1998	In sharp contrast T-cell proliferation mediated by anti-CD6 in the presence of TPA was efficiently blocked by CsA.	Tetradecanoylphorbol Acetate	79-82	CD6 molecule	Homo sapiens	56-59
9515031-3	1998	In the transient transfection assay, TGF-beta1 potentiated NE- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-activated c-fos promoter/enhancer, but not forskolin-activated c-fos promoter/enhancer.	Tetradecanoylphorbol Acetate	66-102	transforming growth factor, beta 1	Rattus norvegicus	37-46
9515031-3	1998	In the transient transfection assay, TGF-beta1 potentiated NE- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-activated c-fos promoter/enhancer, but not forskolin-activated c-fos promoter/enhancer.	Tetradecanoylphorbol Acetate	104-107	transforming growth factor, beta 1	Rattus norvegicus	37-46
9515031-4	1998	The c-fos serum response element (SRE) and the TPA response element (TRE) were responsible for TGF-beta1-induced potentiation of the NE or TPA action.	Tetradecanoylphorbol Acetate	47-50	transforming growth factor, beta 1	Rattus norvegicus	95-104
9515031-4	1998	The c-fos serum response element (SRE) and the TPA response element (TRE) were responsible for TGF-beta1-induced potentiation of the NE or TPA action.	Tetradecanoylphorbol Acetate	139-142	transforming growth factor, beta 1	Rattus norvegicus	95-104
9515031-5	1998	Although TGF-beta1 activated not only the wild-type c-fos SRE, but also the mutated c-fos SRE, which contains an intact binding site for the serum response factor (SRF) but lacks the ternary complex factor (TCF) binding site, TPA activated the wild-type c-fos SRE but not the mutated c-fos SRE.	Tetradecanoylphorbol Acetate	226-229	transforming growth factor, beta 1	Rattus norvegicus	9-18
9610845-3	1998	Retinoic acid also suppressed the IL-6 synthesis stimulated by 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C. The IL-6 synthesis induced by cholera toxin, forskolin or dibutyryl cAMP was inhibited by retinoic acid.	Tetradecanoylphorbol Acetate	63-99	interleukin 6	Mus musculus	34-38
9610845-3	1998	Retinoic acid also suppressed the IL-6 synthesis stimulated by 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C. The IL-6 synthesis induced by cholera toxin, forskolin or dibutyryl cAMP was inhibited by retinoic acid.	Tetradecanoylphorbol Acetate	63-99	interleukin 6	Mus musculus	139-143
9651816-10	1998	Although the addition of 12-o-tetradecanoylphorbol-13-acetate (TPA) singly to the incubation medium had no effect on either Mn-, or Cu,Zn-SOD activity, it significantly augmented the IFN-gamma-dependent induction of Mn-SOD activity by anti-Fas antibody or by TNF-alpha.	Tetradecanoylphorbol Acetate	25-61	interferon gamma	Homo sapiens	183-192
9651816-10	1998	Although the addition of 12-o-tetradecanoylphorbol-13-acetate (TPA) singly to the incubation medium had no effect on either Mn-, or Cu,Zn-SOD activity, it significantly augmented the IFN-gamma-dependent induction of Mn-SOD activity by anti-Fas antibody or by TNF-alpha.	Tetradecanoylphorbol Acetate	25-61	tumor necrosis factor	Homo sapiens	259-268
9651816-10	1998	Although the addition of 12-o-tetradecanoylphorbol-13-acetate (TPA) singly to the incubation medium had no effect on either Mn-, or Cu,Zn-SOD activity, it significantly augmented the IFN-gamma-dependent induction of Mn-SOD activity by anti-Fas antibody or by TNF-alpha.	Tetradecanoylphorbol Acetate	63-66	interferon gamma	Homo sapiens	183-192
12014111-5	1998	To explore molecular mechanism that modulates bFGF release, we treated CNE-2 cells with PMA for two days and found that the treatment increased bFGF gene expression in the cytoplasm and bFGF release significantly after 48 hours.	Tetradecanoylphorbol Acetate	88-91	fibroblast growth factor 2	Homo sapiens	144-148
12014111-5	1998	To explore molecular mechanism that modulates bFGF release, we treated CNE-2 cells with PMA for two days and found that the treatment increased bFGF gene expression in the cytoplasm and bFGF release significantly after 48 hours.	Tetradecanoylphorbol Acetate	88-91	fibroblast growth factor 2	Homo sapiens	144-148
9478937-5	1998	Functional activation of the JNKK/SEK1-JNK/SAPK-c-Jun cascade (where JNKK/SEK1 is JNK kinase/SAPK kinase) was demonstrated by activation of a 12-O-tetradecanoylphorbol-13-acetate response element (TRE) reporter construct in a c-Jun dependent fashion.	Tetradecanoylphorbol Acetate	142-178	mitogen-activated protein kinase kinase 4	Homo sapiens	69-73
9651816-10	1998	Although the addition of 12-o-tetradecanoylphorbol-13-acetate (TPA) singly to the incubation medium had no effect on either Mn-, or Cu,Zn-SOD activity, it significantly augmented the IFN-gamma-dependent induction of Mn-SOD activity by anti-Fas antibody or by TNF-alpha.	Tetradecanoylphorbol Acetate	63-66	tumor necrosis factor	Homo sapiens	259-268
9478937-5	1998	Functional activation of the JNKK/SEK1-JNK/SAPK-c-Jun cascade (where JNKK/SEK1 is JNK kinase/SAPK kinase) was demonstrated by activation of a 12-O-tetradecanoylphorbol-13-acetate response element (TRE) reporter construct in a c-Jun dependent fashion.	Tetradecanoylphorbol Acetate	142-178	mitogen-activated protein kinase kinase 4	Homo sapiens	74-78
9640627-4	1998	On ionomycin + PMA stimulation, which reveals the intrinsic potential of lymphokine production by T cells, the CD57+ T cell subsets from all individuals produced high amounts of IFN-gamma and TNF-alpha mRNA and protein.	Tetradecanoylphorbol Acetate	15-18	beta-1,3-glucuronyltransferase 1	Homo sapiens	111-115
9640627-4	1998	On ionomycin + PMA stimulation, which reveals the intrinsic potential of lymphokine production by T cells, the CD57+ T cell subsets from all individuals produced high amounts of IFN-gamma and TNF-alpha mRNA and protein.	Tetradecanoylphorbol Acetate	15-18	interferon gamma	Homo sapiens	178-187
9640627-4	1998	On ionomycin + PMA stimulation, which reveals the intrinsic potential of lymphokine production by T cells, the CD57+ T cell subsets from all individuals produced high amounts of IFN-gamma and TNF-alpha mRNA and protein.	Tetradecanoylphorbol Acetate	15-18	tumor necrosis factor	Homo sapiens	192-201
9478933-5	1998	Stimulation of ERK by phorbol 12-myristate 13-acetate was not affected in mutant cells, but the phorbol 12-myristate 13-acetate-induced ERK activity decayed much faster compared with that in wild-type cells.	Tetradecanoylphorbol Acetate	22-53	mitogen-activated protein kinase 1	Mus musculus	15-18
9478937-5	1998	Functional activation of the JNKK/SEK1-JNK/SAPK-c-Jun cascade (where JNKK/SEK1 is JNK kinase/SAPK kinase) was demonstrated by activation of a 12-O-tetradecanoylphorbol-13-acetate response element (TRE) reporter construct in a c-Jun dependent fashion.	Tetradecanoylphorbol Acetate	142-178	mitogen-activated protein kinase 8	Homo sapiens	39-42
9478937-5	1998	Functional activation of the JNKK/SEK1-JNK/SAPK-c-Jun cascade (where JNKK/SEK1 is JNK kinase/SAPK kinase) was demonstrated by activation of a 12-O-tetradecanoylphorbol-13-acetate response element (TRE) reporter construct in a c-Jun dependent fashion.	Tetradecanoylphorbol Acetate	142-178	mitogen-activated protein kinase 9	Homo sapiens	93-97
9478933-5	1998	Stimulation of ERK by phorbol 12-myristate 13-acetate was not affected in mutant cells, but the phorbol 12-myristate 13-acetate-induced ERK activity decayed much faster compared with that in wild-type cells.	Tetradecanoylphorbol Acetate	96-127	mitogen-activated protein kinase 1	Mus musculus	15-18
9468516-7	1998	Interestingly, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), known to activate protein kinase C, also enhanced incorporation of [32P]orthophosphate into TTF-1 protein; however, the DNA binding activity of TTF-1 was decreased in nuclear extracts of TPA-treated type II cells.	Tetradecanoylphorbol Acetate	33-69	homeobox protein Nkx-2.1	Papio anubis	169-174
9478933-5	1998	Stimulation of ERK by phorbol 12-myristate 13-acetate was not affected in mutant cells, but the phorbol 12-myristate 13-acetate-induced ERK activity decayed much faster compared with that in wild-type cells.	Tetradecanoylphorbol Acetate	96-127	mitogen-activated protein kinase 1	Mus musculus	136-139
9478937-5	1998	Functional activation of the JNKK/SEK1-JNK/SAPK-c-Jun cascade (where JNKK/SEK1 is JNK kinase/SAPK kinase) was demonstrated by activation of a 12-O-tetradecanoylphorbol-13-acetate response element (TRE) reporter construct in a c-Jun dependent fashion.	Tetradecanoylphorbol Acetate	142-178	mitogen-activated protein kinase kinase 4	Homo sapiens	29-33
9478937-5	1998	Functional activation of the JNKK/SEK1-JNK/SAPK-c-Jun cascade (where JNKK/SEK1 is JNK kinase/SAPK kinase) was demonstrated by activation of a 12-O-tetradecanoylphorbol-13-acetate response element (TRE) reporter construct in a c-Jun dependent fashion.	Tetradecanoylphorbol Acetate	142-178	mitogen-activated protein kinase kinase 4	Homo sapiens	34-38
9478937-5	1998	Functional activation of the JNKK/SEK1-JNK/SAPK-c-Jun cascade (where JNKK/SEK1 is JNK kinase/SAPK kinase) was demonstrated by activation of a 12-O-tetradecanoylphorbol-13-acetate response element (TRE) reporter construct in a c-Jun dependent fashion.	Tetradecanoylphorbol Acetate	142-178	mitogen-activated protein kinase 8	Homo sapiens	29-32
9478937-5	1998	Functional activation of the JNKK/SEK1-JNK/SAPK-c-Jun cascade (where JNKK/SEK1 is JNK kinase/SAPK kinase) was demonstrated by activation of a 12-O-tetradecanoylphorbol-13-acetate response element (TRE) reporter construct in a c-Jun dependent fashion.	Tetradecanoylphorbol Acetate	142-178	mitogen-activated protein kinase 9	Homo sapiens	43-47
9484776-8	1998	Keratinocytes from the HK1.bcl-2 mice were significantly more resistant to cell death induction by U.V.-B, DMBA, and TPA, compared to control keratinocytes.	Tetradecanoylphorbol Acetate	117-120	B cell leukemia/lymphoma 2	Mus musculus	27-32
9468516-7	1998	Interestingly, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), known to activate protein kinase C, also enhanced incorporation of [32P]orthophosphate into TTF-1 protein; however, the DNA binding activity of TTF-1 was decreased in nuclear extracts of TPA-treated type II cells.	Tetradecanoylphorbol Acetate	33-69	homeobox protein Nkx-2.1	Papio anubis	221-226
9484776-9	1998	Furthermore, papillomas developed at a significantly greater frequency and shorter latency in the HK1.bcl-2 mice compared to control littermates following initiation with DMBA and promotion with TPA.	Tetradecanoylphorbol Acetate	195-198	B cell leukemia/lymphoma 2	Mus musculus	102-107
9468516-7	1998	Interestingly, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), known to activate protein kinase C, also enhanced incorporation of [32P]orthophosphate into TTF-1 protein; however, the DNA binding activity of TTF-1 was decreased in nuclear extracts of TPA-treated type II cells.	Tetradecanoylphorbol Acetate	71-74	homeobox protein Nkx-2.1	Papio anubis	169-174
9468516-7	1998	Interestingly, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), known to activate protein kinase C, also enhanced incorporation of [32P]orthophosphate into TTF-1 protein; however, the DNA binding activity of TTF-1 was decreased in nuclear extracts of TPA-treated type II cells.	Tetradecanoylphorbol Acetate	71-74	homeobox protein Nkx-2.1	Papio anubis	221-226
9486128-3	1998	Immunofluorescence showed that thrombin and TPA reduced the cell surface expression of PAR-1.	Tetradecanoylphorbol Acetate	44-47	coagulation factor II thrombin receptor	Homo sapiens	87-92
9461531-10	1998	However, activation of protein kinase C by phorbol 12-myristate 13-acetate increases the level of BKB1R mRNA and the binding of desArg10-kallidin.	Tetradecanoylphorbol Acetate	43-74	bradykinin receptor B1	Homo sapiens	98-103
9514088-6	1998	12-O-Tetradecanoylphorbol-13-acetate (TPA) restored the membrane translocation of PKC-alpha and abrogated the synergistic cytotoxicity of tamoxifen.	Tetradecanoylphorbol Acetate	0-36	protein kinase C alpha	Homo sapiens	82-91
9514088-6	1998	12-O-Tetradecanoylphorbol-13-acetate (TPA) restored the membrane translocation of PKC-alpha and abrogated the synergistic cytotoxicity of tamoxifen.	Tetradecanoylphorbol Acetate	38-41	protein kinase C alpha	Homo sapiens	82-91
9469423-6	1998	Furthermore, both DC subpopulations expressed IL-13 mRNA and protein following activation with PMA-ionomycin, but not with CD40 ligand, in contrast to IL-12 and IL-10, revealing the existence of different pathways for DC activation.	Tetradecanoylphorbol Acetate	95-98	interleukin 13	Homo sapiens	46-51
9480828-3	1998	Pretreatment of Jurkat cells with the Src-family PTK inhibitor herbimycin A resulted in a 50% inhibition of transactivation of the reporter following incubation with PMA.	Tetradecanoylphorbol Acetate	166-169	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	38-41
9476903-7	1998	The combination of 12-O-tetradecanoyl-phorbol-11-acetate (TPA) and terbutaline stimulated secretion of [3H]phosphatidylcholine ([3H]PC), SP-A, and lysozyme, but not SP-D.	Tetradecanoylphorbol Acetate	58-61	surfactant protein A1	Rattus norvegicus	137-141
9486128-5	1998	In contrast, prior activation of PKC with TPA produced desensitization to thrombin and histamine, indicating heterologous PAR-1 desensitization.	Tetradecanoylphorbol Acetate	42-45	coagulation factor II, thrombin	Homo sapiens	74-82
9486128-7	1998	Depletion of PKC beta isozymes (PKC beta I and PKC beta II) by transducing cells with antisense cDNA of PKC beta I prevented the TPA-induced decrease in cell surface PAR-1 expression and restored approximately 60% of the cytosolic Ca2+ signal in response to thrombin.	Tetradecanoylphorbol Acetate	129-132	coagulation factor II thrombin receptor	Homo sapiens	166-171
9486128-7	1998	Depletion of PKC beta isozymes (PKC beta I and PKC beta II) by transducing cells with antisense cDNA of PKC beta I prevented the TPA-induced decrease in cell surface PAR-1 expression and restored approximately 60% of the cytosolic Ca2+ signal in response to thrombin.	Tetradecanoylphorbol Acetate	129-132	coagulation factor II, thrombin	Homo sapiens	258-266
9486215-3	1998	The transcription factor nuclear factor-kappa B (NF-kappa B) frequently mediates regulation of gene expression by TPA and TNF-alpha.	Tetradecanoylphorbol Acetate	114-117	nuclear factor kappa B subunit 1	Homo sapiens	25-47
9473348-6	1998	When the cell lines were treated with the PKC activator, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), WAF1 was accumulated in A-172 cells in a dose-dependent manner but not in T98G cells.	Tetradecanoylphorbol Acetate	57-94	cyclin dependent kinase inhibitor 1A	Homo sapiens	102-106
9486215-3	1998	The transcription factor nuclear factor-kappa B (NF-kappa B) frequently mediates regulation of gene expression by TPA and TNF-alpha.	Tetradecanoylphorbol Acetate	114-117	nuclear factor kappa B subunit 1	Homo sapiens	49-59
9486215-6	1998	By EMSA, TPA and TNF-alpha increased nuclear NF-kappa B binding activity in temporally distinct patterns.	Tetradecanoylphorbol Acetate	9-12	nuclear factor kappa B subunit 1	Homo sapiens	45-55
9486215-7	1998	PDTC decreased TPA- and TNF-alpha-induced NF-kappa B binding activity but did not limit their inhibition of SP-A and SP-B mRNAs.	Tetradecanoylphorbol Acetate	15-18	nuclear factor kappa B subunit 1	Homo sapiens	42-52
9466823-2	1998	The observations that NF-kappa B can be activated in cells by phorbol 12-myristate 13-acetate and in vitro by addition of protein kinase C (PKC) are suggestive of a role of PKC in NF-kappa B activation, which was investigated in the J774A.1 murine macrophage cell line.	Tetradecanoylphorbol Acetate	62-93	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	22-32
9458101-9	1998	Phorbol 12-myristate 13-acetate inhibited CD95-mediated apoptosis by counteracting the IFNgamma-, actinomycin D-, and cycloheximide-mediated but not the brefeldin A-mediated sensitization.	Tetradecanoylphorbol Acetate	0-31	interferon gamma	Homo sapiens	87-95
9538932-5	1998	Treatment of smooth muscle cells with dexamethasone (0.01-0.1 microM Dex) and with the protein kinase C activator, phorbol myristate acetate (0.1 microM PMA), increased NEP mRNA by 3-4 fold and two fold, respectively.	Tetradecanoylphorbol Acetate	115-140	membrane metalloendopeptidase	Homo sapiens	169-172
9538932-6	1998	Dexamethasone (0.1 microM) and prednisolone (0.1 microM) increased protein concentrations of NEP and NEP-activity after 3 days and continued to increase at 5 days, whereas PMA induced maximal increase of NEP concentrations after 48 hours.	Tetradecanoylphorbol Acetate	172-175	membrane metalloendopeptidase	Homo sapiens	93-96
9481485-6	1998	12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC-activating phorbol ester, significantly stimulated IL-6 secretion.	Tetradecanoylphorbol Acetate	0-36	interleukin 6	Mus musculus	101-105
9481485-6	1998	12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC-activating phorbol ester, significantly stimulated IL-6 secretion.	Tetradecanoylphorbol Acetate	38-41	interleukin 6	Mus musculus	101-105
9481485-8	1998	The effect of a combination of ET-1 and TPA on IL-6 secretion was not additive.	Tetradecanoylphorbol Acetate	40-43	interleukin 6	Mus musculus	47-51
9481485-10	1998	Both ET-1- and TPA-induced IL-6 secretion were reduced in PKC downregulated MC3T3-E1 cells.	Tetradecanoylphorbol Acetate	15-18	interleukin 6	Mus musculus	27-31
9473348-6	1998	When the cell lines were treated with the PKC activator, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), WAF1 was accumulated in A-172 cells in a dose-dependent manner but not in T98G cells.	Tetradecanoylphorbol Acetate	96-99	cyclin dependent kinase inhibitor 1A	Homo sapiens	102-106
9473349-0	1998	A role for the MEK/MAPK pathway in PMA-induced cell cycle arrest: modulation of megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	35-38	mitogen-activated protein kinase kinase 7	Homo sapiens	15-18
9473349-3	1998	These PMA-induced changes in K562 cells are preceded by a rapid rise in the activity of MEK (MAP kinase/extracellular regulated kinases) that leads to a sustained activation of ERK2 (extracellular regulated kinase; MAPK).	Tetradecanoylphorbol Acetate	6-9	mitogen-activated protein kinase kinase 7	Homo sapiens	88-91
9473349-3	1998	These PMA-induced changes in K562 cells are preceded by a rapid rise in the activity of MEK (MAP kinase/extracellular regulated kinases) that leads to a sustained activation of ERK2 (extracellular regulated kinase; MAPK).	Tetradecanoylphorbol Acetate	6-9	mitogen-activated protein kinase kinase 7	Homo sapiens	93-135
9473349-3	1998	These PMA-induced changes in K562 cells are preceded by a rapid rise in the activity of MEK (MAP kinase/extracellular regulated kinases) that leads to a sustained activation of ERK2 (extracellular regulated kinase; MAPK).	Tetradecanoylphorbol Acetate	6-9	mitogen-activated protein kinase 1	Homo sapiens	177-181
11324523-4	1998	All of these ET-1-induced cardiomyocyte hypertrophic responses were completely blocked by pretreatment with staurosporine (2 nmol/L), a protein kinase C inhibitor, and stimulated by 4-phorbol, 12-myristate, 13-acetate (PMA) (10(-8)-10(-6) mol/L), a protein kinase C activator, in a dose-dependent manner.	Tetradecanoylphorbol Acetate	219-222	endothelin 1	Rattus norvegicus	13-17
9562863-3	1998	To identify further MMP genes transcribed in T lymphocytes exposed to phorbol 12-myristate 13-acetate and a calcium ionophore, we combined reverse transcription and polymerase chain reaction using primers specific for conserved domains and detected collagenase 3 transcripts, first described in a human breast cancer.	Tetradecanoylphorbol Acetate	70-101	matrix metallopeptidase 13	Homo sapiens	249-262
9428812-5	1998	Phorbol 12-myristate 13-acetate (PMA) induced a prolonged activation of PLD, as detected in both intact cells and membranes.	Tetradecanoylphorbol Acetate	0-31	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	72-75
9428812-5	1998	Phorbol 12-myristate 13-acetate (PMA) induced a prolonged activation of PLD, as detected in both intact cells and membranes.	Tetradecanoylphorbol Acetate	33-36	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	72-75
9428812-9	1998	Ro-31-8220 and bisindolylmaleimide I, inhibitors of protein kinase C, blocked activation by PLD by both PMA and LPA.	Tetradecanoylphorbol Acetate	104-107	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	92-95
9463471-6	1998	The PKC activator, phorbol-12-myristate 13-acetate, induced a long-lasting synaptic enhancement that was blocked by chelerythrine.	Tetradecanoylphorbol Acetate	19-50	proline rich transmembrane protein 2	Homo sapiens	4-7
9463479-1	1998	We have demonstrated previously that protein kinase Calpha (PKCalpha) plays a key role in regulating phospholipase D (PLD) activation by nucleotides and the phorbol ester phorbol-12-myristate-13-acetate in Madin-Darby canine kidney (MDCK-D1) cells.	Tetradecanoylphorbol Acetate	171-202	protein kinase C alpha	Canis lupus familiaris	37-58
9484651-5	1998	Ingestion of IgG-opsonized glass beads, or treatment with phorbol myristate acetate, increased enzymatic activity and tyrosine phosphorylation of p42 MAPK.	Tetradecanoylphorbol Acetate	58-83	mitogen-activated protein kinase 1	Homo sapiens	146-154
9600205-4	1998	In SK-N-SH cells, a 48 hour (h) treatment with 100 ng/ml IL-1beta, 100 ng/ml TNF-alpha, or 100 nM phorbol 12-myristate 13-acetate induced a 2.7- to 4.2-fold increase in the level of PrP mRNA, while the exposure to 100 ng/ml IFN-gamma resulted in a 50% decrease.	Tetradecanoylphorbol Acetate	98-129	prion protein	Homo sapiens	182-185
9600205-4	1998	In SK-N-SH cells, a 48 hour (h) treatment with 100 ng/ml IL-1beta, 100 ng/ml TNF-alpha, or 100 nM phorbol 12-myristate 13-acetate induced a 2.7- to 4.2-fold increase in the level of PrP mRNA, while the exposure to 100 ng/ml IFN-gamma resulted in a 50% decrease.	Tetradecanoylphorbol Acetate	98-129	interferon gamma	Homo sapiens	224-233
9442097-6	1998	Moreover, hSERT phosphorylation induced by beta-phorbol 12-myristate 13-acetate is abolished selectively by the PKC inhibitors staurosporine and bisindolylmaleimide I, whereas hSERT phosphorylation induced by phosphatase inhibitors is insensitive to these agents at comparable concentrations.	Tetradecanoylphorbol Acetate	43-79	solute carrier family 6 member 4	Homo sapiens	10-15
9446602-4	1998	Here, we investigated the role of SPP and the protein kinase C activator, phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), in the caspase cascade leading to the proteolysis of poly(ADP-ribose) polymerase (PARP) and lamins.	Tetradecanoylphorbol Acetate	126-129	poly(ADP-ribose) polymerase 1	Homo sapiens	185-212
9446602-4	1998	Here, we investigated the role of SPP and the protein kinase C activator, phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), in the caspase cascade leading to the proteolysis of poly(ADP-ribose) polymerase (PARP) and lamins.	Tetradecanoylphorbol Acetate	126-129	poly(ADP-ribose) polymerase 1	Homo sapiens	214-218
9446602-5	1998	In Jurkat T cells, Fas ligation or addition of exogenous C2-ceramide induced activations of caspase-3/CPP32 and caspase-7/Mch3 followed by PARP cleavage, effects that can be blocked either by SPP or TPA.	Tetradecanoylphorbol Acetate	199-202	caspase 3	Homo sapiens	92-101
9442087-9	1998	The significance of these findings is shown with adenocarcinoma cells, which, when pretreated with 10 microM DECA and UV light, exhibited diminished 12-O-tetradecanoylphorbol-13-acetate-induced PKC alpha translocation.	Tetradecanoylphorbol Acetate	149-185	protein kinase C alpha	Homo sapiens	194-203
9512645-2	1998	Membrane-associated phospholipase D (PLD) activity in response to guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S) or phorbol myristate acetate (PMA) was upregulated by these treatments.	Tetradecanoylphorbol Acetate	119-144	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	20-35
9475183-3	1998	Upon stimulation by three different activators, phorbol 12-myristate 13-acetate, fluoride and endothelin-1, a translocation of PKC activity from the cytosolic to the particulate fraction was observed.	Tetradecanoylphorbol Acetate	48-79	protein kinase C alpha	Homo sapiens	127-130
9467967-7	1998	Protein kinase C (PKC) depletion by prolonged treatment of VSMC with phorbol 12-myristate 13-acetate (PMA) resulted in partial decrease in the responsiveness of JNK1 to arachidonic acid suggesting a role for both PKC-dependent and -independent mechanisms in the activation of JNK1 by this important fatty acid.	Tetradecanoylphorbol Acetate	69-100	mitogen-activated protein kinase 8	Homo sapiens	161-165
9467967-7	1998	Protein kinase C (PKC) depletion by prolonged treatment of VSMC with phorbol 12-myristate 13-acetate (PMA) resulted in partial decrease in the responsiveness of JNK1 to arachidonic acid suggesting a role for both PKC-dependent and -independent mechanisms in the activation of JNK1 by this important fatty acid.	Tetradecanoylphorbol Acetate	69-100	mitogen-activated protein kinase 8	Homo sapiens	276-280
9467967-7	1998	Protein kinase C (PKC) depletion by prolonged treatment of VSMC with phorbol 12-myristate 13-acetate (PMA) resulted in partial decrease in the responsiveness of JNK1 to arachidonic acid suggesting a role for both PKC-dependent and -independent mechanisms in the activation of JNK1 by this important fatty acid.	Tetradecanoylphorbol Acetate	102-105	mitogen-activated protein kinase 8	Homo sapiens	161-165
9467967-7	1998	Protein kinase C (PKC) depletion by prolonged treatment of VSMC with phorbol 12-myristate 13-acetate (PMA) resulted in partial decrease in the responsiveness of JNK1 to arachidonic acid suggesting a role for both PKC-dependent and -independent mechanisms in the activation of JNK1 by this important fatty acid.	Tetradecanoylphorbol Acetate	102-105	mitogen-activated protein kinase 8	Homo sapiens	276-280
9430696-6	1998	The culture medium of subtype THP-1 cells treated with 12-O-tetradecanoylphorbol-13-acetate inhibited the uptake of Ac-LDL and the expression of ScR in parent THP-1 cells.	Tetradecanoylphorbol Acetate	55-91	GLI family zinc finger 2	Homo sapiens	30-35
9512645-2	1998	Membrane-associated phospholipase D (PLD) activity in response to guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S) or phorbol myristate acetate (PMA) was upregulated by these treatments.	Tetradecanoylphorbol Acetate	119-144	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	37-40
9430696-6	1998	The culture medium of subtype THP-1 cells treated with 12-O-tetradecanoylphorbol-13-acetate inhibited the uptake of Ac-LDL and the expression of ScR in parent THP-1 cells.	Tetradecanoylphorbol Acetate	55-91	GLI family zinc finger 2	Homo sapiens	159-164
9430696-7	1998	After a 48-h incubation in the culture medium containing 12-O-tetradecanoylphorbol-13-acetate, the culture medium of differentiated subtype THP-1 cells contained 6.9 ng/ml transforming growth factor (TGF)-beta 1, while that of parent THP-1 cells secreted below detection level, which was less than 3 ng/ml.	Tetradecanoylphorbol Acetate	57-93	GLI family zinc finger 2	Homo sapiens	140-145
9512645-2	1998	Membrane-associated phospholipase D (PLD) activity in response to guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S) or phorbol myristate acetate (PMA) was upregulated by these treatments.	Tetradecanoylphorbol Acetate	146-149	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	20-35
9430696-7	1998	After a 48-h incubation in the culture medium containing 12-O-tetradecanoylphorbol-13-acetate, the culture medium of differentiated subtype THP-1 cells contained 6.9 ng/ml transforming growth factor (TGF)-beta 1, while that of parent THP-1 cells secreted below detection level, which was less than 3 ng/ml.	Tetradecanoylphorbol Acetate	57-93	transforming growth factor beta 1	Homo sapiens	172-211
9512645-2	1998	Membrane-associated phospholipase D (PLD) activity in response to guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S) or phorbol myristate acetate (PMA) was upregulated by these treatments.	Tetradecanoylphorbol Acetate	146-149	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	37-40
9430696-7	1998	After a 48-h incubation in the culture medium containing 12-O-tetradecanoylphorbol-13-acetate, the culture medium of differentiated subtype THP-1 cells contained 6.9 ng/ml transforming growth factor (TGF)-beta 1, while that of parent THP-1 cells secreted below detection level, which was less than 3 ng/ml.	Tetradecanoylphorbol Acetate	57-93	GLI family zinc finger 2	Homo sapiens	234-239
9425167-7	1998	Although the structure of the alphaE-chain is unique among integrins, the avidity of alphaEbeta7 for E-cadherin can be regulated by divalent cations or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	152-177	cadherin 1	Homo sapiens	101-111
9433911-5	1998	A similar defect of CD8+ cells of HIV+ individuals was also seen with H2O2 levels stimulated with PMA in the presence of a catalase inhibitor.	Tetradecanoylphorbol Acetate	98-101	catalase	Homo sapiens	123-131
9551916-6	1998	Taken together, these results suggest that the NF-kappa B activity, after dissociation from I kappa B, is enhanced by a nuclear factor that is active irrespective of PMA treatment, and the nuclear factor-mediated enhancement is selectively inhibited by E3330.	Tetradecanoylphorbol Acetate	166-169	nuclear factor kappa B subunit 1	Homo sapiens	47-57
9467952-1	1998	In MCF7 breast cancer cells, mitogen-activated protein (MAP) kinase (i.e. Erk-1/2) is activated by the mitogen insulin, but also by the growth inhibiting agent TPA, though with very different kinetics.	Tetradecanoylphorbol Acetate	160-163	mitogen-activated protein kinase 3	Homo sapiens	74-81
9419345-2	1998	Tumor promoters, such as 12-O-tetradecanoylphorbol 13-acetate (TPA) or epidermal growth factor (EGF), induce high levels of activator protein 1 (AP-1) activity and large, tumorigenic, anchorage-independent colonies in soft agar at a high frequency in JB6 P+ cells, but not in JB6 P- cells.	Tetradecanoylphorbol Acetate	25-61	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	124-143
9419345-2	1998	Tumor promoters, such as 12-O-tetradecanoylphorbol 13-acetate (TPA) or epidermal growth factor (EGF), induce high levels of activator protein 1 (AP-1) activity and large, tumorigenic, anchorage-independent colonies in soft agar at a high frequency in JB6 P+ cells, but not in JB6 P- cells.	Tetradecanoylphorbol Acetate	25-61	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	145-149
9419345-2	1998	Tumor promoters, such as 12-O-tetradecanoylphorbol 13-acetate (TPA) or epidermal growth factor (EGF), induce high levels of activator protein 1 (AP-1) activity and large, tumorigenic, anchorage-independent colonies in soft agar at a high frequency in JB6 P+ cells, but not in JB6 P- cells.	Tetradecanoylphorbol Acetate	63-66	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	124-143
9467952-8	1998	On the other hand, PD98059 reverts the inhibitory effect of TPA on cell cycle entry as well as on pRB hyperphosphorylation, indicating that Erk effectors function as inhibitors of proliferation in MCF7 cells.	Tetradecanoylphorbol Acetate	60-63	mitogen-activated protein kinase 1	Homo sapiens	140-143
9419345-2	1998	Tumor promoters, such as 12-O-tetradecanoylphorbol 13-acetate (TPA) or epidermal growth factor (EGF), induce high levels of activator protein 1 (AP-1) activity and large, tumorigenic, anchorage-independent colonies in soft agar at a high frequency in JB6 P+ cells, but not in JB6 P- cells.	Tetradecanoylphorbol Acetate	63-66	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	145-149
9419345-5	1998	TPA and EGF induce transactivation of AP-1 activity in P+ cells but not in P- cells.	Tetradecanoylphorbol Acetate	0-3	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-42
9419345-6	1998	Nonphosphorylated forms and TPA- or EGF-induced phosphorylated forms of Erks (Erk1 and Erk2) in P- cells were much lower than those in P+ cells.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 3	Homo sapiens	72-76
9419345-6	1998	Nonphosphorylated forms and TPA- or EGF-induced phosphorylated forms of Erks (Erk1 and Erk2) in P- cells were much lower than those in P+ cells.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 3	Homo sapiens	78-82
9419345-6	1998	Nonphosphorylated forms and TPA- or EGF-induced phosphorylated forms of Erks (Erk1 and Erk2) in P- cells were much lower than those in P+ cells.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 1	Homo sapiens	87-91
9419345-7	1998	Stable transfection of wild-type MAPK (Erk2) into P- cells restored its response to TPA and EGF for both AP-1 activation and cell transformation.	Tetradecanoylphorbol Acetate	84-87	mitogen-activated protein kinase 1	Homo sapiens	39-43
9419345-7	1998	Stable transfection of wild-type MAPK (Erk2) into P- cells restored its response to TPA and EGF for both AP-1 activation and cell transformation.	Tetradecanoylphorbol Acetate	84-87	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-109
9419349-5	1998	ITF also decreased activation of ERK activity induced by either transforming growth factor-alpha, which links extracellular stimuli to the Ras/Raf/MEK/ERK pathway via the epidermal growth factor receptor, or phorbol 12-myristate 13-acetate, which activates Raf through protein kinase C. ITF-induced inhibition of ERK activity was blocked by an inhibitor of tyrosine and dual-specific phosphatases, sodium orthovanadate.	Tetradecanoylphorbol Acetate	208-239	Eph receptor B1	Rattus norvegicus	33-36
9467952-2	1998	Insulin induces a relatively transient activation of Erk2 (&lt;15 min), whereas TPA is able to induce a prolonged activation of Erk2 (&gt;6 h).	Tetradecanoylphorbol Acetate	80-83	mitogen-activated protein kinase 1	Homo sapiens	128-132
9467952-4	1998	Whereas insulin stimulates prolonged induction of c-jun, but not of junB mRNA, resulting in c-jun expression during the entire G1 period, the growth inhibitor TPA induces junB much longer than c-jun.	Tetradecanoylphorbol Acetate	159-162	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	171-175
9467952-5	1998	Inhibition of the Erk2 pathway by PD98059, specific for the upstream MAP kinase kinase (MEK1), abolishes TPA-stimulated junB but not insulin-induced c-jun.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase 1	Homo sapiens	18-22
9467952-5	1998	Inhibition of the Erk2 pathway by PD98059, specific for the upstream MAP kinase kinase (MEK1), abolishes TPA-stimulated junB but not insulin-induced c-jun.	Tetradecanoylphorbol Acetate	105-108	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-124
9797013-4	1998	Removal of fetal calf serum (FCS) from the culture medium or addition of forskolin or phorbol ester (TPA) also induced rapid elevation of aromatase mRNA and switching to exon 1c, whereas TGFbeta almost abolished the expression, suggesting that cancer cells might secret forskolin- or TPA-like stimulatory factors, or consume TGFbeta-like inhibitory factors in serum for expression of aromatase mRNA.	Tetradecanoylphorbol Acetate	101-104	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	138-147
9459490-4	1998	Treatment of rat cardiomyocytes with AVP, Ang II and phorbol 12-myristate 13-acetate (PMA) increases the activation of ERKs.	Tetradecanoylphorbol Acetate	86-89	arginine vasopressin	Rattus norvegicus	37-40
9699011-0	1998	Effect of phorbol ester (PMA) on antioxidant enzyme expression in TGF-beta 1-induced apoptosis in primary cultures of hepatocytes.	Tetradecanoylphorbol Acetate	25-28	transforming growth factor beta 1	Homo sapiens	66-76
9797013-4	1998	Removal of fetal calf serum (FCS) from the culture medium or addition of forskolin or phorbol ester (TPA) also induced rapid elevation of aromatase mRNA and switching to exon 1c, whereas TGFbeta almost abolished the expression, suggesting that cancer cells might secret forskolin- or TPA-like stimulatory factors, or consume TGFbeta-like inhibitory factors in serum for expression of aromatase mRNA.	Tetradecanoylphorbol Acetate	101-104	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	384-393
9472709-5	1998	These results indicate that the inhibitory actions of TPA and PB on GJIC are cell-specific rather than connexin-specific and that TPA inhibits connexin43 and connexin32-mediated GJIC through a protein kinase C-dependent mechanism.	Tetradecanoylphorbol Acetate	130-133	gap junction protein, alpha 1	Rattus norvegicus	143-153
9472686-9	1998	CD5 expression increased on PBL following treatment with phorbol myristate acetate (PMA), lipopolysaccharide (LPS), or immobilized anti-IgM.	Tetradecanoylphorbol Acetate	57-82	CD5 molecule	Sus scrofa	0-3
9828078-2	1998	It has been shown previously that IFN-gamma induces increased CB activity in phorbol myristate acetate (PMA)-primed THP-1 cells.	Tetradecanoylphorbol Acetate	77-102	interferon gamma	Homo sapiens	34-43
9828078-2	1998	It has been shown previously that IFN-gamma induces increased CB activity in phorbol myristate acetate (PMA)-primed THP-1 cells.	Tetradecanoylphorbol Acetate	104-107	interferon gamma	Homo sapiens	34-43
9831302-7	1998	Our results indicate that i) glucosamine is a potent stimulator of PKC-translocation exhibiting an isoenzyme specific translocation kinetic which is different from PMA-induced PKC-isoenzyme translocation ii) the hexosamine pathway may be possibly involved in the high glucose-induced activation of PKC.	Tetradecanoylphorbol Acetate	164-167	protein kinase C alpha	Homo sapiens	67-70
9831302-7	1998	Our results indicate that i) glucosamine is a potent stimulator of PKC-translocation exhibiting an isoenzyme specific translocation kinetic which is different from PMA-induced PKC-isoenzyme translocation ii) the hexosamine pathway may be possibly involved in the high glucose-induced activation of PKC.	Tetradecanoylphorbol Acetate	164-167	protein kinase C alpha	Homo sapiens	176-179
9831302-7	1998	Our results indicate that i) glucosamine is a potent stimulator of PKC-translocation exhibiting an isoenzyme specific translocation kinetic which is different from PMA-induced PKC-isoenzyme translocation ii) the hexosamine pathway may be possibly involved in the high glucose-induced activation of PKC.	Tetradecanoylphorbol Acetate	164-167	protein kinase C alpha	Homo sapiens	176-179
9533826-6	1998	Phorbol esters (PMA), activators of PKC, also raised the immunoreactive levels of ET-1 and Big ET-1 while, staurosporine, a PKC inhibitor (20 nm), decreased ET-1 levels in TNF-alpha-stimulated cells.	Tetradecanoylphorbol Acetate	16-19	endothelin 1	Homo sapiens	82-99
9533826-6	1998	Phorbol esters (PMA), activators of PKC, also raised the immunoreactive levels of ET-1 and Big ET-1 while, staurosporine, a PKC inhibitor (20 nm), decreased ET-1 levels in TNF-alpha-stimulated cells.	Tetradecanoylphorbol Acetate	16-19	endothelin 1	Homo sapiens	82-86
9533826-6	1998	Phorbol esters (PMA), activators of PKC, also raised the immunoreactive levels of ET-1 and Big ET-1 while, staurosporine, a PKC inhibitor (20 nm), decreased ET-1 levels in TNF-alpha-stimulated cells.	Tetradecanoylphorbol Acetate	16-19	tumor necrosis factor	Homo sapiens	172-181
9710361-8	1998	This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min.	Tetradecanoylphorbol Acetate	97-100	growth hormone releasing hormone	Homo sapiens	216-219
9710361-8	1998	This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min.	Tetradecanoylphorbol Acetate	97-100	growth hormone 1	Homo sapiens	262-264
9710361-8	1998	This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min.	Tetradecanoylphorbol Acetate	97-100	growth hormone releasing hormone	Homo sapiens	386-389
9710361-8	1998	This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min.	Tetradecanoylphorbol Acetate	243-246	growth hormone releasing hormone	Homo sapiens	216-219
9710361-8	1998	This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min.	Tetradecanoylphorbol Acetate	243-246	growth hormone releasing hormone	Homo sapiens	216-219
9710361-10	1998	Furthermore, the GRF-induced increase in cFos mRNA level by GRF and TPA did not appear to be participated straightforward in the GH gene expression, suggesting that cFos alone is insufficient to the activation.	Tetradecanoylphorbol Acetate	68-71	growth hormone releasing hormone	Homo sapiens	17-20
9453354-0	1998	Vascular endothelial growth factor mRNA in pericytes is upregulated by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	71-96	vascular endothelial growth factor A	Homo sapiens	0-34
9453354-3	1998	The goal of the present study was to evaluate the effects of phorbol myristate acetate (PMA), a substance known to produce nonhydrostatic pulmonary edema in intact animals, on VEGF gene expression in pericyte cultures.	Tetradecanoylphorbol Acetate	61-86	vascular endothelial growth factor A	Homo sapiens	176-180
9453354-3	1998	The goal of the present study was to evaluate the effects of phorbol myristate acetate (PMA), a substance known to produce nonhydrostatic pulmonary edema in intact animals, on VEGF gene expression in pericyte cultures.	Tetradecanoylphorbol Acetate	88-91	vascular endothelial growth factor A	Homo sapiens	176-180
9397161-10	1998	The effect of IFN-gamma in KG-1 cells was synergistic with that of PMA.	Tetradecanoylphorbol Acetate	67-70	interferon gamma	Homo sapiens	14-23
10195234-7	1998	In U937 cells, TNF-alpha and phorbol myristate acetate (PMA) stimulated CXCR4 gene transcription; this effect was reversed with prior treatment of cells with IFN-gamma.	Tetradecanoylphorbol Acetate	29-54	interferon gamma	Homo sapiens	158-167
10195234-7	1998	In U937 cells, TNF-alpha and phorbol myristate acetate (PMA) stimulated CXCR4 gene transcription; this effect was reversed with prior treatment of cells with IFN-gamma.	Tetradecanoylphorbol Acetate	56-59	interferon gamma	Homo sapiens	158-167
9666308-2	1998	In fact, epidermal growth factor was an excellent mitogen, even after prolonged pretreatment of cells with TPA, suggesting that the PKC isoform implicated in proliferation is not down-regulated by 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	107-110	protein kinase C alpha	Homo sapiens	132-135
9666308-2	1998	In fact, epidermal growth factor was an excellent mitogen, even after prolonged pretreatment of cells with TPA, suggesting that the PKC isoform implicated in proliferation is not down-regulated by 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	236-239	protein kinase C alpha	Homo sapiens	132-135
9666308-8	1998	PKC-alpha, -delta, and -epsilon were down-regulated by pretreatment of cells with TPA, while PKC-zeta was unaffected.	Tetradecanoylphorbol Acetate	82-85	protein kinase C alpha	Homo sapiens	0-31
9709308-4	1998	The HHV-8 vIL-6, vDHFR, vTS, and vBcl-2 proteins have all been shown to be active in a variety of appropriate functional assays, and transcripts from vIL-6, vMIP-1B, vIE1-A, vIE1-B, and vDHFR genes are all expressed as abundant single messenger RNA species after butyrate or phorbol ester (TPA) induction of the lytic cycle in HHV8-positive BCBL cell lines.	Tetradecanoylphorbol Acetate	290-293	ORF16	Human gammaherpesvirus 8	33-39
9496701-1	1998	A peptide fraction of low molecular weight (Vueffe) prepared from bovine Factor VIII by enzymatic hydrolysis with trypsin, reduces significantly (p&lt;0.05) membrane bound protein kinase C (PKC) activity in cultured bovine pulmonary artery endothelial cells grown with enhanced glucose levels (22.2 mM) or stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	320-351	coagulation factor VIII	Bos taurus	73-84
9496701-1	1998	A peptide fraction of low molecular weight (Vueffe) prepared from bovine Factor VIII by enzymatic hydrolysis with trypsin, reduces significantly (p&lt;0.05) membrane bound protein kinase C (PKC) activity in cultured bovine pulmonary artery endothelial cells grown with enhanced glucose levels (22.2 mM) or stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	353-356	coagulation factor VIII	Bos taurus	73-84
9472686-9	1998	CD5 expression increased on PBL following treatment with phorbol myristate acetate (PMA), lipopolysaccharide (LPS), or immobilized anti-IgM.	Tetradecanoylphorbol Acetate	84-87	CD5 molecule	Sus scrofa	0-3
9609459-4	1998	Semiquantitative PCR showed that phorbol myristate acetate (100 nM) increased the ratio of PCR products for MCP-1 to housekeeping gene glyceraldehyde-3-phosphate dehydrogenase on densitometric results at 24 h by 2.7-fold, which was prevented by calphostin C (200 nM) pretreatment.	Tetradecanoylphorbol Acetate	33-58	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	135-175
9460707-3	1998	Protein level of Bcl-2 was decreased by pretreatment with diBu-cAMP or staurosporine, and, on the contrary, the level was increased by pretreatment with PMA.	Tetradecanoylphorbol Acetate	153-156	BCL2 apoptosis regulator	Homo sapiens	17-22
9857376-7	1998	Furthermore, incubation of mesangial cells 24 h with 100 nM renin provoked an increase of tPA and of PAI1 in the conditioned medium.	Tetradecanoylphorbol Acetate	90-93	renin	Homo sapiens	60-65
9704334-10	1998	Phorbol 12-myristate 13-acetate (PMA, 2 or 5 nM) protected CCE cells against apoptosis induced by the introduction of TGF-beta 1 and withdrawal of aFGF, bFGF or VEGF, while H7 (50 microM), but not HA1004 (50 microM), abrogated the protective effect of PMA on CCE apoptosis.	Tetradecanoylphorbol Acetate	33-36	fibroblast growth factor 1	Mus musculus	147-151
10063971-7	1998	We also explored the PKC mechanism(s) responsible for the synergism of TPA and gemcitabine, and determined that treatment with 10 nM TPA for 24 h in BG-1 cells: 1) downregulated PKCdelta and PKCalpha, without affecting PKCepsilon, 2) did not affect cell cycle distribution into S phase.	Tetradecanoylphorbol Acetate	71-74	proline rich transmembrane protein 2	Homo sapiens	21-24
9704334-10	1998	Phorbol 12-myristate 13-acetate (PMA, 2 or 5 nM) protected CCE cells against apoptosis induced by the introduction of TGF-beta 1 and withdrawal of aFGF, bFGF or VEGF, while H7 (50 microM), but not HA1004 (50 microM), abrogated the protective effect of PMA on CCE apoptosis.	Tetradecanoylphorbol Acetate	0-31	fibroblast growth factor 1	Mus musculus	147-151
10063971-7	1998	We also explored the PKC mechanism(s) responsible for the synergism of TPA and gemcitabine, and determined that treatment with 10 nM TPA for 24 h in BG-1 cells: 1) downregulated PKCdelta and PKCalpha, without affecting PKCepsilon, 2) did not affect cell cycle distribution into S phase.	Tetradecanoylphorbol Acetate	133-136	proline rich transmembrane protein 2	Homo sapiens	21-24
10063971-0	1998	The effects of gemcitabine and TPA on PKC signaling in BG-1 human ovarian cancer cells.	Tetradecanoylphorbol Acetate	31-34	proline rich transmembrane protein 2	Homo sapiens	38-41
10063971-7	1998	We also explored the PKC mechanism(s) responsible for the synergism of TPA and gemcitabine, and determined that treatment with 10 nM TPA for 24 h in BG-1 cells: 1) downregulated PKCdelta and PKCalpha, without affecting PKCepsilon, 2) did not affect cell cycle distribution into S phase.	Tetradecanoylphorbol Acetate	133-136	protein kinase C alpha	Homo sapiens	191-199
10063971-3	1998	Coincubation of 10 nM TPA with pharmacological inhibitors of PKC abrogated the synergism of TPA and gemcitabine.	Tetradecanoylphorbol Acetate	22-25	proline rich transmembrane protein 2	Homo sapiens	61-64
10223619-6	1998	TPA-treated PC Cl 3 cells are unable to trap iodide and the expression levels of thyroglobulin, TSH receptor, and TPO genes are drastically reduced by TPA treatment.	Tetradecanoylphorbol Acetate	0-3	thyroglobulin	Rattus norvegicus	81-94
10063971-3	1998	Coincubation of 10 nM TPA with pharmacological inhibitors of PKC abrogated the synergism of TPA and gemcitabine.	Tetradecanoylphorbol Acetate	92-95	proline rich transmembrane protein 2	Homo sapiens	61-64
10063971-4	1998	These observations prompted further investigation of PKC signaling events linked to TPA and gemcitabine cytotoxicity in BG-1 cells.	Tetradecanoylphorbol Acetate	84-87	proline rich transmembrane protein 2	Homo sapiens	53-56
10223619-6	1998	TPA-treated PC Cl 3 cells are unable to trap iodide and the expression levels of thyroglobulin, TSH receptor, and TPO genes are drastically reduced by TPA treatment.	Tetradecanoylphorbol Acetate	151-154	thyroglobulin	Rattus norvegicus	81-94
9405454-3	1997	Tyrosine phosphorylation of Pyk2 was also induced by the calcium ionophore A23187, by phorbol myristate acetate, or by stimulation of G-protein-coupled receptors.	Tetradecanoylphorbol Acetate	86-111	protein tyrosine kinase 2 beta	Rattus norvegicus	28-32
9437731-0	1998	Additional recognition sites in the C-terminal heparin-binding domain of fibronectin promote adhesion of PMA-treated U937 cells.	Tetradecanoylphorbol Acetate	105-108	fibronectin 1	Homo sapiens	73-84
9437731-1	1998	Recently we have shown an evidence that a peptide, corresponding to residues Gln1892 to Gly1910, from the C-terminal heparin-binding domain of fibronectin promotes adhesion of phorbol-12-myristate 13-acetate (PMA)-treated U937 cells and binds to both integrin alpha 4 beta 1 and glycosaminoglycans on U937 cells surface.	Tetradecanoylphorbol Acetate	176-207	fibronectin 1	Homo sapiens	143-154
9437731-1	1998	Recently we have shown an evidence that a peptide, corresponding to residues Gln1892 to Gly1910, from the C-terminal heparin-binding domain of fibronectin promotes adhesion of phorbol-12-myristate 13-acetate (PMA)-treated U937 cells and binds to both integrin alpha 4 beta 1 and glycosaminoglycans on U937 cells surface.	Tetradecanoylphorbol Acetate	209-212	fibronectin 1	Homo sapiens	143-154
9437731-2	1998	We present additional adhesion-promoting sites to PMA-treated U937 cells present in the C-terminal heparin-binding domain of fibronectin.	Tetradecanoylphorbol Acetate	50-53	fibronectin 1	Homo sapiens	125-136
9645418-2	1998	When the peripheral mononuclear cells were stimulated with phorbol myristate acetate and ionomycin in the presence of monensin, which blocks the secretion of cytokines, the positive rates for the cytoplasmic IL-2 and IFN-gamma were lower and those for the cytoplasmic IL-4 and IL-10 were higher in SLE than in normal subjects.	Tetradecanoylphorbol Acetate	59-84	interferon gamma	Mus musculus	217-226
9645418-2	1998	When the peripheral mononuclear cells were stimulated with phorbol myristate acetate and ionomycin in the presence of monensin, which blocks the secretion of cytokines, the positive rates for the cytoplasmic IL-2 and IFN-gamma were lower and those for the cytoplasmic IL-4 and IL-10 were higher in SLE than in normal subjects.	Tetradecanoylphorbol Acetate	59-84	interleukin 10	Mus musculus	277-282
9458327-5	1998	PKC activator, phorbol 12-myristate 13-acetate (PMA) and PKA activator, dibutyryl cAMP could replace LPS in priming the cells for IFN- stimulation but 8-bromo-cGMP did not.	Tetradecanoylphorbol Acetate	15-46	interferon alpha 1	Homo sapiens	130-133
9458327-5	1998	PKC activator, phorbol 12-myristate 13-acetate (PMA) and PKA activator, dibutyryl cAMP could replace LPS in priming the cells for IFN- stimulation but 8-bromo-cGMP did not.	Tetradecanoylphorbol Acetate	48-51	interferon alpha 1	Homo sapiens	130-133
9388190-0	1997	12-O-Tetradecanoylphorbol-13-acetate activates the Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of SOS involving serine phosphorylation of Shc in NIH3T3 cells.	Tetradecanoylphorbol Acetate	0-36	mitogen-activated protein kinase 1	Mus musculus	94-97
9550423-4	1997	Baseline levels of ICE mRNA were detected in keratinocyte cultures devoid of Langerhans cells and were up-regulated by nontoxic concentrations of the reactive hapten urushiol and by the irritant chemicals sodium lauryl sulfate and PMA.	Tetradecanoylphorbol Acetate	231-234	caspase 1	Homo sapiens	19-22
9388222-5	1997	However, AP1 induction by 4beta-phorbol 12-myristate 13-acetate, which up-regulates Ras activity in a protein kinase C-dependent, TCR/tyrosine kinase-independent manner, was not affected by Cbl overexpression.	Tetradecanoylphorbol Acetate	26-63	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	9-12
9434740-6	1997	Induction of the MnSOD mRNA by phorbol-12-myristate-13-acetate (PMA) was only slightly diminished in the presence of PDTC, which in contrast virtually eliminated induction of the NF kappa B-dependent transcript I kappa B-alpha by PMA.	Tetradecanoylphorbol Acetate	64-67	nuclear factor kappa B subunit 1	Homo sapiens	179-189
9434740-6	1997	Induction of the MnSOD mRNA by phorbol-12-myristate-13-acetate (PMA) was only slightly diminished in the presence of PDTC, which in contrast virtually eliminated induction of the NF kappa B-dependent transcript I kappa B-alpha by PMA.	Tetradecanoylphorbol Acetate	64-67	NFKB inhibitor alpha	Homo sapiens	211-226
9434740-10	1997	In vitro DNA binding studies confirmed strong AP-1 activation under conditions where NF kappa B is blocked but the MnSOD transcript is strongly induced (e.g., PMA treatment in the presence of PDTC).	Tetradecanoylphorbol Acetate	159-162	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	46-50
9388270-4	1997	The anti-proliferative effect of TPA in these cells may be accounted for, at least in part, by the MAPK-dependent stimulation of the synthesis of p21(WAF1/CIP1), an inhibitor of cyclin/cyclin-dependent kinase complexes.	Tetradecanoylphorbol Acetate	33-36	cyclin dependent kinase inhibitor 1A	Homo sapiens	146-149
9388190-1	1997	We investigated the activation of the Ras/ERK signaling pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA) in NIH3T3 fibroblasts.	Tetradecanoylphorbol Acetate	67-103	mitogen-activated protein kinase 1	Mus musculus	42-45
9388190-1	1997	We investigated the activation of the Ras/ERK signaling pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA) in NIH3T3 fibroblasts.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase 1	Mus musculus	42-45
9388190-6	1997	Taken together, these results suggest that the TPA signal was fed at or upstream of Shc to activate the Ras/ERK signaling pathway involving serine phosphorylation of Shc.	Tetradecanoylphorbol Acetate	47-50	mitogen-activated protein kinase 1	Mus musculus	108-111
9388270-4	1997	The anti-proliferative effect of TPA in these cells may be accounted for, at least in part, by the MAPK-dependent stimulation of the synthesis of p21(WAF1/CIP1), an inhibitor of cyclin/cyclin-dependent kinase complexes.	Tetradecanoylphorbol Acetate	33-36	cyclin dependent kinase inhibitor 1A	Homo sapiens	150-154
9388270-4	1997	The anti-proliferative effect of TPA in these cells may be accounted for, at least in part, by the MAPK-dependent stimulation of the synthesis of p21(WAF1/CIP1), an inhibitor of cyclin/cyclin-dependent kinase complexes.	Tetradecanoylphorbol Acetate	33-36	cyclin dependent kinase inhibitor 1A	Homo sapiens	155-159
9408252-7	1997	Production of both IL-6 and IL-8 was stimulated in a concentration-dependent fashion by interleukin-1beta (0.1-10 ng/ml), tumor necrosis factor-alpha (1-100 ng/ml), and bacterial lipopolysaccharide (0.1-10 microg/ml), and also by 100 nM phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	237-268	interleukin 6	Homo sapiens	19-23
9503684-5	1997	Furthermore, the frequency of T cells which produced IL-4, IL-5 and IFN-gamma stimulated with phorbol myristate acetate and ionomycin increased and reduced in parallel with MFI of EG2-positive cells.	Tetradecanoylphorbol Acetate	94-119	interleukin 4	Homo sapiens	53-57
9503684-5	1997	Furthermore, the frequency of T cells which produced IL-4, IL-5 and IFN-gamma stimulated with phorbol myristate acetate and ionomycin increased and reduced in parallel with MFI of EG2-positive cells.	Tetradecanoylphorbol Acetate	94-119	interferon gamma	Homo sapiens	68-77
9408252-7	1997	Production of both IL-6 and IL-8 was stimulated in a concentration-dependent fashion by interleukin-1beta (0.1-10 ng/ml), tumor necrosis factor-alpha (1-100 ng/ml), and bacterial lipopolysaccharide (0.1-10 microg/ml), and also by 100 nM phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	237-268	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
9408252-7	1997	Production of both IL-6 and IL-8 was stimulated in a concentration-dependent fashion by interleukin-1beta (0.1-10 ng/ml), tumor necrosis factor-alpha (1-100 ng/ml), and bacterial lipopolysaccharide (0.1-10 microg/ml), and also by 100 nM phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	237-268	interleukin 1 beta	Homo sapiens	88-105
9419420-7	1997	Treatment with Epo or 12-O-tetradecanoyl-phorbol-13-acetate (TPA) up-regulated expression of GATA-2 and Bcl-xL, and these elevations were inhibited by inhibitors of protein kinase C (PKC), H7 and H8.	Tetradecanoylphorbol Acetate	22-59	BCL2 like 1	Homo sapiens	104-110
9419420-7	1997	Treatment with Epo or 12-O-tetradecanoyl-phorbol-13-acetate (TPA) up-regulated expression of GATA-2 and Bcl-xL, and these elevations were inhibited by inhibitors of protein kinase C (PKC), H7 and H8.	Tetradecanoylphorbol Acetate	61-64	erythropoietin	Homo sapiens	15-18
9419420-7	1997	Treatment with Epo or 12-O-tetradecanoyl-phorbol-13-acetate (TPA) up-regulated expression of GATA-2 and Bcl-xL, and these elevations were inhibited by inhibitors of protein kinase C (PKC), H7 and H8.	Tetradecanoylphorbol Acetate	61-64	BCL2 like 1	Homo sapiens	104-110
9409644-7	1997	In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period.	Tetradecanoylphorbol Acetate	146-149	interleukin 2	Homo sapiens	27-31
9409644-7	1997	In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period.	Tetradecanoylphorbol Acetate	146-149	interferon gamma	Homo sapiens	36-52
9409644-7	1997	In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period.	Tetradecanoylphorbol Acetate	146-149	interferon gamma	Homo sapiens	54-63
9369943-0	1997	PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	36-39
9417811-6	1997	Exposure of osteoblasts to a high dose of phorbol myristoyl acetate (PMA) to deplete PKC activity abolished CGRP-mediated TNF-alpha suppression.	Tetradecanoylphorbol Acetate	69-72	tumor necrosis factor	Rattus norvegicus	122-131
9559292-6	1997	Chromogranin A was expressed by TM87-16 only after treatment with either TPA or RA.	Tetradecanoylphorbol Acetate	73-76	chromogranin A	Homo sapiens	0-14
9369949-8	1997	Blocking the activities of either PLA2 or LOX inhibited F-actin formation and cell spreading, both of which were reversed by TPA treatment.	Tetradecanoylphorbol Acetate	125-128	phospholipase A2 group IB	Homo sapiens	34-38
9452362-0	1997	Stabilization of invariant chain mRNA by 12-O-tetradecanoylphorbol-13-acetate is blocked by IFN-gamma in a murine B lymphoma cell line.	Tetradecanoylphorbol Acetate	41-77	interferon gamma	Mus musculus	92-101
9452362-5	1997	However, cotreatment of cells with TPA and IFN-gamma resulted in a block in the TPA-induced increase in Ii expression.	Tetradecanoylphorbol Acetate	80-83	interferon gamma	Mus musculus	43-52
9452362-7	1997	IFN-gamma did, however, block stabilization of Ii mRNA by TPA.	Tetradecanoylphorbol Acetate	58-61	interferon gamma	Mus musculus	0-9
9430861-5	1997	METHODS: Adhesion of CD4+ T cells from dialysis patients to intact ECM and its immobilized moieties, fibronectin (FN) and laminin (LN) was measured following phorbol-12-myristate-13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	158-189	CD4 molecule	Homo sapiens	21-24
11596184-4	1997	The effects of PMA and A23187 suggested that the pathway of PKC and calcium is involved in the production and secretion of interleukin 6.	Tetradecanoylphorbol Acetate	15-18	interleukin 6	Mus musculus	123-136
9453463-4	1997	Migration induced by either LPA or thrombin was inhibited by the actin cytoskeleton-disrupting agent, cytochalasin B, by the Rho protein-inactivating Clostridium difficile toxin B, by preventing [Ca2+]i transients with an intracellular calcium-chelating agent, and by the phorbol ester, phorbol 12-myristate 13-acetate, which also blocked the LPA- and thrombin-induced [Ca2+]i increases.	Tetradecanoylphorbol Acetate	287-318	coagulation factor II, thrombin	Homo sapiens	35-43
9354686-5	1997	Because the extracellular content of VEGF in human neutrophils supernatants remained constant over a period of 2 to 24 hours and because PMA is a potent inducer of human neutrophil degranulation, the PMA-induced secretion of VEGF may be due to a pre-existing intracellular pool of this molecule.	Tetradecanoylphorbol Acetate	137-140	vascular endothelial growth factor A	Homo sapiens	37-41
9354686-5	1997	Because the extracellular content of VEGF in human neutrophils supernatants remained constant over a period of 2 to 24 hours and because PMA is a potent inducer of human neutrophil degranulation, the PMA-induced secretion of VEGF may be due to a pre-existing intracellular pool of this molecule.	Tetradecanoylphorbol Acetate	200-203	vascular endothelial growth factor A	Homo sapiens	37-41
9354686-3	1997	The present work shows that phorbol-12-myristate 13-acetate (PMA), fMet-Leu-Phe, and tumor necrosis factor-alpha (TNF-alpha) triggered a time-dependent secretion of VEGF by human neutrophils.	Tetradecanoylphorbol Acetate	28-59	vascular endothelial growth factor A	Homo sapiens	165-169
9354686-5	1997	Because the extracellular content of VEGF in human neutrophils supernatants remained constant over a period of 2 to 24 hours and because PMA is a potent inducer of human neutrophil degranulation, the PMA-induced secretion of VEGF may be due to a pre-existing intracellular pool of this molecule.	Tetradecanoylphorbol Acetate	200-203	vascular endothelial growth factor A	Homo sapiens	225-229
9354686-3	1997	The present work shows that phorbol-12-myristate 13-acetate (PMA), fMet-Leu-Phe, and tumor necrosis factor-alpha (TNF-alpha) triggered a time-dependent secretion of VEGF by human neutrophils.	Tetradecanoylphorbol Acetate	61-64	vascular endothelial growth factor A	Homo sapiens	165-169
9354686-8	1997	A dosedependent inhibition of PMA-induced VEGF secretion was observed when the cells were incubated in the presence of pentoxifylline, a methylxanthine known to inhibit neutrophil degranulation.	Tetradecanoylphorbol Acetate	30-33	vascular endothelial growth factor A	Homo sapiens	42-46
9388466-3	1997	Either the depletion of PKC by prolonged treatment of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) or the inhibition of PKC by a selective PKC inhibitor, UCN-01-ME, attenuated UVC-activation of ERK1/2, keeping the activation of JNK1/2 intact.	Tetradecanoylphorbol Acetate	65-101	protein kinase C, alpha	Mus musculus	24-27
9388466-3	1997	Either the depletion of PKC by prolonged treatment of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) or the inhibition of PKC by a selective PKC inhibitor, UCN-01-ME, attenuated UVC-activation of ERK1/2, keeping the activation of JNK1/2 intact.	Tetradecanoylphorbol Acetate	103-106	protein kinase C, alpha	Mus musculus	24-27
9360988-4	1997	A C/EBP-binding site within the CD11c promoter (CEBP-80) is bound by CEBPalpha in undifferentiated U937 cells and by C/EBPalpha- and C/EBPbeta-containing dimers in phorbol 12-myristate 13-acetate-differentiating cells, and its disruption decreased the CD11c promoter activity in a cell type-dependent manner.	Tetradecanoylphorbol Acetate	164-195	CCAAT enhancer binding protein alpha	Homo sapiens	69-78
9360988-4	1997	A C/EBP-binding site within the CD11c promoter (CEBP-80) is bound by CEBPalpha in undifferentiated U937 cells and by C/EBPalpha- and C/EBPbeta-containing dimers in phorbol 12-myristate 13-acetate-differentiating cells, and its disruption decreased the CD11c promoter activity in a cell type-dependent manner.	Tetradecanoylphorbol Acetate	164-195	CCAAT enhancer binding protein alpha	Homo sapiens	117-134
9374733-6	1997	Nonetheless, 25 microM t-BOOH increased PMA-stimulated p47phox translocation, whereas 100 microM t-BOOH decreased PMA-stimulated translocation.	Tetradecanoylphorbol Acetate	40-43	NSFL1 cofactor	Rattus norvegicus	55-58
9409785-0	1997	Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2.	Tetradecanoylphorbol Acetate	59-62	plasminogen activator, urokinase	Homo sapiens	37-40
9409785-1	1997	We have previously shown in NIH 3T3 fibroblasts that treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) or fibroblast growth factor-2 (FGF-2) activates the Ras/Erk signaling pathway in NIH 3T3 fibroblasts, leading to the induction of the urokinase-type plasminogen activator (uPA) gene.	Tetradecanoylphorbol Acetate	68-104	plasminogen activator, urokinase	Homo sapiens	245-281
9409785-1	1997	We have previously shown in NIH 3T3 fibroblasts that treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) or fibroblast growth factor-2 (FGF-2) activates the Ras/Erk signaling pathway in NIH 3T3 fibroblasts, leading to the induction of the urokinase-type plasminogen activator (uPA) gene.	Tetradecanoylphorbol Acetate	68-104	plasminogen activator, urokinase	Homo sapiens	283-286
9409785-1	1997	We have previously shown in NIH 3T3 fibroblasts that treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) or fibroblast growth factor-2 (FGF-2) activates the Ras/Erk signaling pathway in NIH 3T3 fibroblasts, leading to the induction of the urokinase-type plasminogen activator (uPA) gene.	Tetradecanoylphorbol Acetate	106-109	plasminogen activator, urokinase	Homo sapiens	245-281
9409785-1	1997	We have previously shown in NIH 3T3 fibroblasts that treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) or fibroblast growth factor-2 (FGF-2) activates the Ras/Erk signaling pathway in NIH 3T3 fibroblasts, leading to the induction of the urokinase-type plasminogen activator (uPA) gene.	Tetradecanoylphorbol Acetate	106-109	plasminogen activator, urokinase	Homo sapiens	283-286
9409785-3	1997	DNase I hypersensitive (HS) site analysis of the uPA promoter showed that two regions were enhanced after TPA and FGF-2 treatment.	Tetradecanoylphorbol Acetate	106-109	plasminogen activator, urokinase	Homo sapiens	49-52
9393876-4	1997	In C3H 10T1/2 cells, p38/RK and its downstream kinase MAPKAP K-2 are activated by all stimuli used with the exception of TPA.	Tetradecanoylphorbol Acetate	121-124	MAP kinase-activated protein kinase 2	Mus musculus	54-64
9374783-9	1997	Stimulation of PKC with phorbol 12-myristate 13-acetate (PMA) dramatically increased basal Pa without significantly changing the cytosolic calcium level.	Tetradecanoylphorbol Acetate	24-55	proline rich transmembrane protein 2	Homo sapiens	15-18
9374783-9	1997	Stimulation of PKC with phorbol 12-myristate 13-acetate (PMA) dramatically increased basal Pa without significantly changing the cytosolic calcium level.	Tetradecanoylphorbol Acetate	57-60	proline rich transmembrane protein 2	Homo sapiens	15-18
9404722-2	1997	Whereas brain-derived neurotrophic factor (BDNF) or phorbol 12-myristate-13-acetate (PMA) induces NPY production in rat cultures, only PMA does so in human cultures.	Tetradecanoylphorbol Acetate	52-83	neuropeptide Y	Rattus norvegicus	98-101
9404722-2	1997	Whereas brain-derived neurotrophic factor (BDNF) or phorbol 12-myristate-13-acetate (PMA) induces NPY production in rat cultures, only PMA does so in human cultures.	Tetradecanoylphorbol Acetate	85-88	neuropeptide Y	Rattus norvegicus	98-101
9427323-1	1997	Activation of PKC with 12-tetra-decanoylphorbol-13-acetate (TPA) or inhibition with staurosporine or calphostin C down-regulated GnRH mRNA levels.	Tetradecanoylphorbol Acetate	60-63	protein kinase C, alpha	Mus musculus	14-17
9427323-4	1997	However, PKC inhibitors blocked the TPA-evoked c-fos induction.	Tetradecanoylphorbol Acetate	36-39	protein kinase C, alpha	Mus musculus	9-12
9353351-8	1997	The regulatory domain of PKCepsilon enhanced cell growth in the absence or presence of phorbol 12-myristate 13-acetate (PMA), and, in the presence of PMA, all chimeras with the PKCepsilon regulatory domain also gave rise to colonies in soft agar; the role of the catalytic domain of PKCepsilon was evident in the PMA-treated cells that overexpressed the PKC chimera containing the delta regulatory and the epsilon catalytic domains (PKCdelta/epsilon).	Tetradecanoylphorbol Acetate	87-118	protein kinase C, alpha	Mus musculus	25-28
9374646-2	1997	Phorbol 12-myristate 13-acetate (PMA) caused a synergistic increase in BK- and A-23187-induced release of AA but alone had no effect on this release.	Tetradecanoylphorbol Acetate	0-31	kininogen 1	Canis lupus familiaris	71-73
9374646-2	1997	Phorbol 12-myristate 13-acetate (PMA) caused a synergistic increase in BK- and A-23187-induced release of AA but alone had no effect on this release.	Tetradecanoylphorbol Acetate	33-36	kininogen 1	Canis lupus familiaris	71-73
9374646-4	1997	Downregulation of PKC with 100 nM PMA resulted in a reduction of AA release induced by BK or A-23187 addition, which corresponded to a decrease in cytoplasmic phospholipase A2 (cPLA2) activity as measured in cell extracts.	Tetradecanoylphorbol Acetate	34-37	kininogen 1	Canis lupus familiaris	87-89
9409245-3	1997	These phosphoproteins, called pp80, pp27, and pp18 based on apparent M(r) in kD, were also phosphorylated by acute treatment of cells with phorbol myristate acetate, suggesting that they are regulated in response to PKC activation.	Tetradecanoylphorbol Acetate	139-164	branched chain amino acid transaminase 2	Homo sapiens	46-50
9344462-1	1997	Stimulation of phosphatidylethanolamine (PtdEtn) synthesis by the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) has reportedly been found only in hepatocytes expressing the alpha-, betaII-, epsilon-, and zeta-PKC isozymes.	Tetradecanoylphorbol Acetate	99-130	protein kinase C alpha	Homo sapiens	84-87
9344462-7	1997	In contrast, in MCF-7 cells overexpressing PKC-alpha, and as a consequence also expressing the betaI- and betaII-PKC isoforms, PMA effectively stimulated the synthesis of PtdEtn.	Tetradecanoylphorbol Acetate	127-130	protein kinase C alpha	Homo sapiens	43-52
9344462-8	1997	Finally, in HL60 human leukemia cells, which contains PKC-betaII as the major PKC isoform, PMA again stimulated PtdEtn synthesis.	Tetradecanoylphorbol Acetate	91-94	protein kinase C alpha	Homo sapiens	54-57
9366465-8	1997	RESULTS: MuOR mRNA levels decreased in a dose- and time-dependent manner after tetradecanoyl phorbol acetate (TPA) was administered to activate PKC.	Tetradecanoylphorbol Acetate	79-108	proline rich transmembrane protein 2	Homo sapiens	144-147
9366465-8	1997	RESULTS: MuOR mRNA levels decreased in a dose- and time-dependent manner after tetradecanoyl phorbol acetate (TPA) was administered to activate PKC.	Tetradecanoylphorbol Acetate	110-113	proline rich transmembrane protein 2	Homo sapiens	144-147
9366465-10	1997	The actions of TPA were blocked by pretreatment with the selective PKC inhibitor bisindolylmaleimide, but not by inhibition of protein synthesis with cycloheximide or anisomycin.	Tetradecanoylphorbol Acetate	15-18	proline rich transmembrane protein 2	Homo sapiens	67-70
9467850-3	1997	The first of these TPA states is senescence, and several recent studies have shown that abrogation of p53 function permits temporary escape from senescence that ends in a poorly characterized form of arrest (referred to as p53-minus TPA) in which the pRB and p16INK4 genes appear to be involved.	Tetradecanoylphorbol Acetate	19-22	tumor protein p53	Homo sapiens	102-105
9416426-2	1997	A structure-activity relationship study of these phthalimide analogues revealed that their inhibitory effects on TPA- and OA-induced TNF-alpha production by THP-1 cells are well correlated to each other, i.e. they may involve the same target molecule(s).	Tetradecanoylphorbol Acetate	113-116	tumor necrosis factor	Homo sapiens	133-142
9467850-3	1997	The first of these TPA states is senescence, and several recent studies have shown that abrogation of p53 function permits temporary escape from senescence that ends in a poorly characterized form of arrest (referred to as p53-minus TPA) in which the pRB and p16INK4 genes appear to be involved.	Tetradecanoylphorbol Acetate	233-236	tumor protein p53	Homo sapiens	102-105
9372245-5	1997	Pretreatment of the cells with PKC inhibitors, CGP 41251 or tamoxifen, inhibited tyrosine phosphorylation of Erk1 and Erk2 MAP kinases induced by low concentrations of SP or TPA and significantly attenuated phosphorylation at high concentrations of SP or TPA.	Tetradecanoylphorbol Acetate	255-258	protein kinase C alpha	Homo sapiens	31-34
9351440-6	1997	The deletion analysis revealed that the c-fos serum response element (SRE) and the 12-O-tetradecanoylphorbol-13-acetate response element (TRE) mainly account for c-fos luciferase expression by RhoA Val14.	Tetradecanoylphorbol Acetate	83-119	ras homolog family member A	Homo sapiens	193-197
9372245-4	1997	SP peptide, epidermal growth factor, and the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induced the tyrosine phosphorylation of the Erk1 and Erk2 MAP kinases in a concentration-dependent manner in U-373 MG cells.	Tetradecanoylphorbol Acetate	59-95	mitogen-activated protein kinase 3	Homo sapiens	146-150
9372245-4	1997	SP peptide, epidermal growth factor, and the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induced the tyrosine phosphorylation of the Erk1 and Erk2 MAP kinases in a concentration-dependent manner in U-373 MG cells.	Tetradecanoylphorbol Acetate	59-95	mitogen-activated protein kinase 1	Homo sapiens	155-159
9372245-5	1997	Pretreatment of the cells with PKC inhibitors, CGP 41251 or tamoxifen, inhibited tyrosine phosphorylation of Erk1 and Erk2 MAP kinases induced by low concentrations of SP or TPA and significantly attenuated phosphorylation at high concentrations of SP or TPA.	Tetradecanoylphorbol Acetate	255-258	mitogen-activated protein kinase 3	Homo sapiens	109-113
9372245-4	1997	SP peptide, epidermal growth factor, and the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induced the tyrosine phosphorylation of the Erk1 and Erk2 MAP kinases in a concentration-dependent manner in U-373 MG cells.	Tetradecanoylphorbol Acetate	97-100	tachykinin precursor 1	Homo sapiens	0-2
9372245-5	1997	Pretreatment of the cells with PKC inhibitors, CGP 41251 or tamoxifen, inhibited tyrosine phosphorylation of Erk1 and Erk2 MAP kinases induced by low concentrations of SP or TPA and significantly attenuated phosphorylation at high concentrations of SP or TPA.	Tetradecanoylphorbol Acetate	255-258	mitogen-activated protein kinase 1	Homo sapiens	118-122
9372245-4	1997	SP peptide, epidermal growth factor, and the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induced the tyrosine phosphorylation of the Erk1 and Erk2 MAP kinases in a concentration-dependent manner in U-373 MG cells.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 3	Homo sapiens	146-150
9372245-4	1997	SP peptide, epidermal growth factor, and the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induced the tyrosine phosphorylation of the Erk1 and Erk2 MAP kinases in a concentration-dependent manner in U-373 MG cells.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 1	Homo sapiens	155-159
9372245-9	1997	Prolonged treatment with TPA resulted in down-regulation of PKC and selective inhibition of TPA- and SP-induced Erk1 and Erk2 tyrosine phosphorylation in U-373 MG cells.	Tetradecanoylphorbol Acetate	25-28	protein kinase C alpha	Homo sapiens	60-63
9372245-5	1997	Pretreatment of the cells with PKC inhibitors, CGP 41251 or tamoxifen, inhibited tyrosine phosphorylation of Erk1 and Erk2 MAP kinases induced by low concentrations of SP or TPA and significantly attenuated phosphorylation at high concentrations of SP or TPA.	Tetradecanoylphorbol Acetate	174-177	protein kinase C alpha	Homo sapiens	31-34
9372245-5	1997	Pretreatment of the cells with PKC inhibitors, CGP 41251 or tamoxifen, inhibited tyrosine phosphorylation of Erk1 and Erk2 MAP kinases induced by low concentrations of SP or TPA and significantly attenuated phosphorylation at high concentrations of SP or TPA.	Tetradecanoylphorbol Acetate	174-177	mitogen-activated protein kinase 3	Homo sapiens	109-113
9372245-5	1997	Pretreatment of the cells with PKC inhibitors, CGP 41251 or tamoxifen, inhibited tyrosine phosphorylation of Erk1 and Erk2 MAP kinases induced by low concentrations of SP or TPA and significantly attenuated phosphorylation at high concentrations of SP or TPA.	Tetradecanoylphorbol Acetate	174-177	mitogen-activated protein kinase 1	Homo sapiens	118-122
9420139-3	1997	METHODS AND RESULTS: We studied the effect of interleukin 7 (IL-7) on the expression of CD23 in normal PBT cells stimulated with PMA + Ca2.	Tetradecanoylphorbol Acetate	129-132	interleukin 7	Homo sapiens	46-59
9420139-0	1997	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol 12myristate 13acetate activated CD4+ CD23+ T-cell subset.	Tetradecanoylphorbol Acetate	87-116	interleukin 7	Homo sapiens	15-28
9420139-0	1997	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol 12myristate 13acetate activated CD4+ CD23+ T-cell subset.	Tetradecanoylphorbol Acetate	87-116	integrin subunit beta 2	Homo sapiens	49-54
9420139-0	1997	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol 12myristate 13acetate activated CD4+ CD23+ T-cell subset.	Tetradecanoylphorbol Acetate	87-116	CD4 molecule	Homo sapiens	127-130
9420139-3	1997	METHODS AND RESULTS: We studied the effect of interleukin 7 (IL-7) on the expression of CD23 in normal PBT cells stimulated with PMA + Ca2.	Tetradecanoylphorbol Acetate	129-132	interleukin 7	Homo sapiens	61-65
9372245-9	1997	Prolonged treatment with TPA resulted in down-regulation of PKC and selective inhibition of TPA- and SP-induced Erk1 and Erk2 tyrosine phosphorylation in U-373 MG cells.	Tetradecanoylphorbol Acetate	25-28	tachykinin precursor 1	Homo sapiens	101-103
9372245-9	1997	Prolonged treatment with TPA resulted in down-regulation of PKC and selective inhibition of TPA- and SP-induced Erk1 and Erk2 tyrosine phosphorylation in U-373 MG cells.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase 3	Homo sapiens	112-116
9372245-9	1997	Prolonged treatment with TPA resulted in down-regulation of PKC and selective inhibition of TPA- and SP-induced Erk1 and Erk2 tyrosine phosphorylation in U-373 MG cells.	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase 1	Homo sapiens	121-125
9372245-9	1997	Prolonged treatment with TPA resulted in down-regulation of PKC and selective inhibition of TPA- and SP-induced Erk1 and Erk2 tyrosine phosphorylation in U-373 MG cells.	Tetradecanoylphorbol Acetate	92-95	mitogen-activated protein kinase 3	Homo sapiens	112-116
9372245-9	1997	Prolonged treatment with TPA resulted in down-regulation of PKC and selective inhibition of TPA- and SP-induced Erk1 and Erk2 tyrosine phosphorylation in U-373 MG cells.	Tetradecanoylphorbol Acetate	92-95	mitogen-activated protein kinase 1	Homo sapiens	121-125
9356174-4	1997	To investigate the regulation of lens cell gap junctions by protein kinase C (PKC), differentiating lens cultures were treated with the PKC activator 12-O-tetradecanoylphorbol-13-acetate (beta-TPA).	Tetradecanoylphorbol Acetate	150-186	protein kinase C alpha	Homo sapiens	78-81
9367627-2	1997	A major phosphoprotein of 20 kDa in resting neutrophils was markedly dephosphorylated upon activation of cells with chemotactic peptide or phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	139-170	protein kinase C alpha	Homo sapiens	212-215
9367627-2	1997	A major phosphoprotein of 20 kDa in resting neutrophils was markedly dephosphorylated upon activation of cells with chemotactic peptide or phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	172-175	protein kinase C alpha	Homo sapiens	212-215
9328828-6	1997	Our results also suggest that the 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated inhibition of apoptosis in serum withdrawn C3H-10T1/2 cells functions through a sequential activation of protein kinase C and the Na+/H+ antiporter; thus, an alkalinization or an inhibition of acidification is involved in this apoptotic block.	Tetradecanoylphorbol Acetate	34-70	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	216-233
9367627-8	1997	Ca(2+)-independent PKC isoforms, rather than PKC alpha or beta, may thus be involved in PMA-induced cofilin dephosphorylation.	Tetradecanoylphorbol Acetate	88-91	protein kinase C alpha	Homo sapiens	19-22
9367627-8	1997	Ca(2+)-independent PKC isoforms, rather than PKC alpha or beta, may thus be involved in PMA-induced cofilin dephosphorylation.	Tetradecanoylphorbol Acetate	88-91	protein kinase C alpha	Homo sapiens	45-54
9394805-5	1997	Cell activation by phorbol 12-myristate 13-acetate (PMA) treatment had a slight effect on increasing CD40L mRNA and protein levels.	Tetradecanoylphorbol Acetate	19-50	CD40 ligand	Homo sapiens	101-106
9394805-5	1997	Cell activation by phorbol 12-myristate 13-acetate (PMA) treatment had a slight effect on increasing CD40L mRNA and protein levels.	Tetradecanoylphorbol Acetate	52-55	CD40 ligand	Homo sapiens	101-106
9568534-1	1997	Phorbol esters such as 12-O-tetradeonyl phorbol-13 acetate (TPA) induce a time-dependent biphasic effect on protein kinase C (PKC)-mediated events by fostering translocation of cytosolic (latent) PKC to the plasma membrane (where it is activated).	Tetradecanoylphorbol Acetate	60-63	proline rich transmembrane protein 2	Homo sapiens	108-124
9568534-1	1997	Phorbol esters such as 12-O-tetradeonyl phorbol-13 acetate (TPA) induce a time-dependent biphasic effect on protein kinase C (PKC)-mediated events by fostering translocation of cytosolic (latent) PKC to the plasma membrane (where it is activated).	Tetradecanoylphorbol Acetate	60-63	proline rich transmembrane protein 2	Homo sapiens	126-129
9568534-1	1997	Phorbol esters such as 12-O-tetradeonyl phorbol-13 acetate (TPA) induce a time-dependent biphasic effect on protein kinase C (PKC)-mediated events by fostering translocation of cytosolic (latent) PKC to the plasma membrane (where it is activated).	Tetradecanoylphorbol Acetate	60-63	proline rich transmembrane protein 2	Homo sapiens	196-199
9568534-3	1997	Previous studies from several laboratories have demonstrated that long-term TPA treatment, like treatment with PKC inhibitors, induces neuronal differentiation.	Tetradecanoylphorbol Acetate	76-79	proline rich transmembrane protein 2	Homo sapiens	111-114
9328828-6	1997	Our results also suggest that the 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated inhibition of apoptosis in serum withdrawn C3H-10T1/2 cells functions through a sequential activation of protein kinase C and the Na+/H+ antiporter; thus, an alkalinization or an inhibition of acidification is involved in this apoptotic block.	Tetradecanoylphorbol Acetate	72-75	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	216-233
9328828-8	1997	TPA was also capable of inhibiting the apoptosis induced by specific inhibitors of protein kinase C and the Na+/H+ antiporter, but the inhibition was successful only if the TPA was administered at least 20 min prior to the addition of the enzyme inhibitor.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	108-125
9379028-4	1997	Transient expression assays using CXCR4 promoter/luciferase gene reporter constructs revealed that stimulation with PMA plus ionomycin up-regulates the CXCR4 promoter activity in the A3.01 CD4+ T cell line and PBL and that a DNA fragment from -93 to +59 relative to the transcription start site contributes markedly to the basal and induced activity.	Tetradecanoylphorbol Acetate	116-119	CD4 molecule	Homo sapiens	189-192
9406171-3	1997	Our study focused on the possible roles of PAI-1, PAI-2, and uPA in tPA in myocyte hypertrophy and angiogenesis in the early and late stages of pressure overload induced left ventricular hypertrophy (LVH).	Tetradecanoylphorbol Acetate	68-71	serpin family E member 1	Sus scrofa	43-48
9433916-5	1997	Among the substances examined, cortisol and TGF-beta suppressed PAF-AH secretion from TPA-stimulated HL-60 cells in a significant and dose-dependent way.	Tetradecanoylphorbol Acetate	86-89	transforming growth factor beta 1	Homo sapiens	44-52
9367827-5	1997	Further experiments demonstrated that in THP-1 cells pretreated with PMA, Dex potently synergized with IL-1 to stimulate G-CSF production.	Tetradecanoylphorbol Acetate	69-72	GLI family zinc finger 2	Homo sapiens	41-46
9367828-1	1997	v-Src transcriptionally induces gene expression by activating several transcriptional response elements such as the serum response element (SRE), the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (TRE), and the c-AMP response element (CRE) found in the promoters of several proliferation-related immediate early genes.	Tetradecanoylphorbol Acetate	150-186	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	2-5
9367828-1	1997	v-Src transcriptionally induces gene expression by activating several transcriptional response elements such as the serum response element (SRE), the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (TRE), and the c-AMP response element (CRE) found in the promoters of several proliferation-related immediate early genes.	Tetradecanoylphorbol Acetate	188-191	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	2-5
9367839-4	1997	We found that HMC-1 cells express c-met and that c-met expression can be upregulated by treatment of the cells with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	116-147	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	49-54
9367839-4	1997	We found that HMC-1 cells express c-met and that c-met expression can be upregulated by treatment of the cells with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	149-152	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	49-54
9367839-5	1997	Although HGF did not detectably influence the proliferation or morphology of HMC-1 cells, HGF inhibited the cells" ability to release tumor necrosis factor-alpha (TNF-alpha) in response to stimulation with PMA and the calcium ionophore, A23187.	Tetradecanoylphorbol Acetate	206-209	tumor necrosis factor	Homo sapiens	134-161
9367839-5	1997	Although HGF did not detectably influence the proliferation or morphology of HMC-1 cells, HGF inhibited the cells" ability to release tumor necrosis factor-alpha (TNF-alpha) in response to stimulation with PMA and the calcium ionophore, A23187.	Tetradecanoylphorbol Acetate	206-209	tumor necrosis factor	Homo sapiens	163-172
9392422-3	1997	The protein kinase C (PKC) inhibitors calphostin C and staurosporine prevented TPA-mediated LDL receptor mRNA induction.	Tetradecanoylphorbol Acetate	79-82	protein kinase C alpha	Homo sapiens	22-25
9392422-6	1997	Treatment of HepG2 cells with 100 nM TPA resulted in translocation of cytosolic PKC alpha to the particulate fraction, with a maximum at 30 min-2 h of treatment, but was without effect on the subcellular distribution of the other isozymes.	Tetradecanoylphorbol Acetate	37-40	protein kinase C alpha	Homo sapiens	80-89
9392422-7	1997	TPA treatment also led to activation of the mitogen-activated protein kinase (MAPK) ERK cascade.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	78-82
9392422-7	1997	TPA treatment also led to activation of the mitogen-activated protein kinase (MAPK) ERK cascade.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	84-87
9392422-8	1997	The specific MAPK pathway inhibitor PD98059 blocked TPA-induced ERK activation.	Tetradecanoylphorbol Acetate	52-55	mitogen-activated protein kinase 1	Homo sapiens	13-17
9392422-8	1997	The specific MAPK pathway inhibitor PD98059 blocked TPA-induced ERK activation.	Tetradecanoylphorbol Acetate	52-55	mitogen-activated protein kinase 1	Homo sapiens	64-67
9392422-10	1997	Moreover, pretreatment of cells with calphostin C inhibited TPA-mediated ERK activation and LDL receptor mRNA induction in a dose-dependent fashion.	Tetradecanoylphorbol Acetate	60-63	mitogen-activated protein kinase 1	Homo sapiens	73-76
9392422-11	1997	Based on a close kinetic correlation between PKC alpha translocation and ERK activation, and the effects of specific inhibitors, these findings suggest that translocation/activation of PKC alpha, and subsequent activation of the Raf-1/MEK/ERK MAPK cascade, represent key events in the transcriptional induction of LDL receptor gene by TPA in HepG2 cells.	Tetradecanoylphorbol Acetate	335-338	mitogen-activated protein kinase 1	Homo sapiens	73-76
9392422-11	1997	Based on a close kinetic correlation between PKC alpha translocation and ERK activation, and the effects of specific inhibitors, these findings suggest that translocation/activation of PKC alpha, and subsequent activation of the Raf-1/MEK/ERK MAPK cascade, represent key events in the transcriptional induction of LDL receptor gene by TPA in HepG2 cells.	Tetradecanoylphorbol Acetate	335-338	protein kinase C alpha	Homo sapiens	185-194
9392422-11	1997	Based on a close kinetic correlation between PKC alpha translocation and ERK activation, and the effects of specific inhibitors, these findings suggest that translocation/activation of PKC alpha, and subsequent activation of the Raf-1/MEK/ERK MAPK cascade, represent key events in the transcriptional induction of LDL receptor gene by TPA in HepG2 cells.	Tetradecanoylphorbol Acetate	335-338	mitogen-activated protein kinase kinase 7	Homo sapiens	235-238
9392422-11	1997	Based on a close kinetic correlation between PKC alpha translocation and ERK activation, and the effects of specific inhibitors, these findings suggest that translocation/activation of PKC alpha, and subsequent activation of the Raf-1/MEK/ERK MAPK cascade, represent key events in the transcriptional induction of LDL receptor gene by TPA in HepG2 cells.	Tetradecanoylphorbol Acetate	335-338	mitogen-activated protein kinase 1	Homo sapiens	239-242
9392422-11	1997	Based on a close kinetic correlation between PKC alpha translocation and ERK activation, and the effects of specific inhibitors, these findings suggest that translocation/activation of PKC alpha, and subsequent activation of the Raf-1/MEK/ERK MAPK cascade, represent key events in the transcriptional induction of LDL receptor gene by TPA in HepG2 cells.	Tetradecanoylphorbol Acetate	335-338	mitogen-activated protein kinase 1	Homo sapiens	243-247
9346918-6	1997	In contrast, 12-O-tetradecanoylphorbol-13-acetate-induced JNK activation could be observed in both JY and MS1418 cells.	Tetradecanoylphorbol Acetate	13-49	mitogen-activated protein kinase 8	Homo sapiens	58-61
9367827-1	1997	The human monocytic leukemic cell line, THP-1, which differentiates toward macrophages in response to phorbol 12-myristate 13-acetate (PMA) was investigated for its ability to produce granulocyte colony-stimulating factor (G-CSF).	Tetradecanoylphorbol Acetate	102-133	GLI family zinc finger 2	Homo sapiens	40-45
9367827-1	1997	The human monocytic leukemic cell line, THP-1, which differentiates toward macrophages in response to phorbol 12-myristate 13-acetate (PMA) was investigated for its ability to produce granulocyte colony-stimulating factor (G-CSF).	Tetradecanoylphorbol Acetate	135-138	GLI family zinc finger 2	Homo sapiens	40-45
9367827-3	1997	However, when combined, PMA and Dex synergistically stimulated THP-1 cells to produce G-CSF.	Tetradecanoylphorbol Acetate	24-27	GLI family zinc finger 2	Homo sapiens	63-68
9341140-3	1997	Gastrin and phorbol 12-myristate 13-acetate (PMA) treatment of AGS-B cells was found to increase the phosphorylation of tyrosine residues of extracellular signal-regulated kinases (ERKs) 1 and 2 and increase ERK activity as determined by the in vitro phosphorylation of myelin basic protein.	Tetradecanoylphorbol Acetate	12-43	mitogen-activated protein kinase 3	Homo sapiens	181-185
9341140-3	1997	Gastrin and phorbol 12-myristate 13-acetate (PMA) treatment of AGS-B cells was found to increase the phosphorylation of tyrosine residues of extracellular signal-regulated kinases (ERKs) 1 and 2 and increase ERK activity as determined by the in vitro phosphorylation of myelin basic protein.	Tetradecanoylphorbol Acetate	12-43	mitogen-activated protein kinase 1	Homo sapiens	181-184
9341140-3	1997	Gastrin and phorbol 12-myristate 13-acetate (PMA) treatment of AGS-B cells was found to increase the phosphorylation of tyrosine residues of extracellular signal-regulated kinases (ERKs) 1 and 2 and increase ERK activity as determined by the in vitro phosphorylation of myelin basic protein.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase 3	Homo sapiens	181-185
9341140-3	1997	Gastrin and phorbol 12-myristate 13-acetate (PMA) treatment of AGS-B cells was found to increase the phosphorylation of tyrosine residues of extracellular signal-regulated kinases (ERKs) 1 and 2 and increase ERK activity as determined by the in vitro phosphorylation of myelin basic protein.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase 1	Homo sapiens	181-184
9341140-4	1997	Reporter gene assays also demonstrated that gastrin and PMA stimulated Elk-1- and c-Myc-dependent transactivation, consistent with gastrin- and PMA-induced activation of ERKs.	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase 3	Homo sapiens	170-174
9341140-4	1997	Reporter gene assays also demonstrated that gastrin and PMA stimulated Elk-1- and c-Myc-dependent transactivation, consistent with gastrin- and PMA-induced activation of ERKs.	Tetradecanoylphorbol Acetate	144-147	mitogen-activated protein kinase 3	Homo sapiens	170-174
9341140-6	1997	Interruption of the ERK-related pathway using expression vectors for kinase-deficient ERKs or an ERK-specific phosphatase (PAC-1) blocked gastrin- and PMA-stimulated HDC promoter activity.	Tetradecanoylphorbol Acetate	151-154	mitogen-activated protein kinase 1	Homo sapiens	20-23
9341140-6	1997	Interruption of the ERK-related pathway using expression vectors for kinase-deficient ERKs or an ERK-specific phosphatase (PAC-1) blocked gastrin- and PMA-stimulated HDC promoter activity.	Tetradecanoylphorbol Acetate	151-154	mitogen-activated protein kinase 3	Homo sapiens	86-90
9341140-6	1997	Interruption of the ERK-related pathway using expression vectors for kinase-deficient ERKs or an ERK-specific phosphatase (PAC-1) blocked gastrin- and PMA-stimulated HDC promoter activity.	Tetradecanoylphorbol Acetate	151-154	mitogen-activated protein kinase 1	Homo sapiens	86-89
9356353-1	1997	Activating protein-1 (AP-1) binding TPA responsive elements (TRE) are located downstream of the transcription initiation site in the U5 region of the HIV-1 long terminal repeat (LTR).	Tetradecanoylphorbol Acetate	36-39	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	22-26
9342371-6	1997	001), returning to the baseline by 24 h. Stretch-induced VPF secretion was partially prevented both by the protein kinase C (PKC) inhibitor H7 (50 microM: 72% inhibition, P &lt; 0.05) and by pretreatment with phorbol ester (phorbol-12-myristate-13 acetate 10(-)7 M: 77% inhibition, P &lt; 0.05).	Tetradecanoylphorbol Acetate	224-255	vascular endothelial growth factor A	Homo sapiens	57-60
9406171-3	1997	Our study focused on the possible roles of PAI-1, PAI-2, and uPA in tPA in myocyte hypertrophy and angiogenesis in the early and late stages of pressure overload induced left ventricular hypertrophy (LVH).	Tetradecanoylphorbol Acetate	68-71	serpin family E member 1	Sus scrofa	43-46
9406171-3	1997	Our study focused on the possible roles of PAI-1, PAI-2, and uPA in tPA in myocyte hypertrophy and angiogenesis in the early and late stages of pressure overload induced left ventricular hypertrophy (LVH).	Tetradecanoylphorbol Acetate	68-71	plasminogen activator, urokinase	Sus scrofa	61-64
18372514-2	1997	The protein kinase C (PKC)-agonist TPA enhanced invasion by 15%, whereas its antagonists staurosporine, chelerythrine and calphostin C were inhibiting by up to 62%.	Tetradecanoylphorbol Acetate	35-38	proline rich transmembrane protein 2	Homo sapiens	4-20
18372514-2	1997	The protein kinase C (PKC)-agonist TPA enhanced invasion by 15%, whereas its antagonists staurosporine, chelerythrine and calphostin C were inhibiting by up to 62%.	Tetradecanoylphorbol Acetate	35-38	proline rich transmembrane protein 2	Homo sapiens	22-25
9366247-5	1997	Moreover, in contrast to sphingosine which activates phospholipase D (PLD) leading to an increase in phosphatidic acid levels, sphingomyelinase, but not ceramide analogs, reduced TPA-stimulated PLD activity.	Tetradecanoylphorbol Acetate	179-182	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	53-68
9366247-5	1997	Moreover, in contrast to sphingosine which activates phospholipase D (PLD) leading to an increase in phosphatidic acid levels, sphingomyelinase, but not ceramide analogs, reduced TPA-stimulated PLD activity.	Tetradecanoylphorbol Acetate	179-182	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	70-73
9377579-0	1997	Re-expression of elafin in 21MT2 breast carcinomas by phorbol 12-myristate 13-acetate is mediated by the Ap1 site in the elafin promoter.	Tetradecanoylphorbol Acetate	54-85	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-108
9334224-2	1997	Ca2+ entry through the capacitative (store-regulated) pathway was shown to be inhibited in neutrophil granulocytes by the protein kinase C activator phorbol 12-myristate 13-acetate and the chemoattractant N-formyl-methionyl-leucyl-phenylalanine (fMLP) by a hitherto unknown mechanism.	Tetradecanoylphorbol Acetate	149-180	formyl peptide receptor 1	Homo sapiens	246-250
9377579-4	1997	By deletion analysis and mutagenesis, we have identified the Ap1 site in the promoter as the cis element mediating transcriptional activation of elafin in 70N normal breast cells and its induction by phorbol 12-myristate 13-acetate (PMA) in 21MT2 breast tumors.	Tetradecanoylphorbol Acetate	200-231	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	61-64
9406911-18	1997	The concomitant addition of combinations of co-activator molecules (DA, TPA and IBMX/forskolin) and aFGF resulted in the additive induction of TH.	Tetradecanoylphorbol Acetate	72-75	tyrosine hydroxylase	Homo sapiens	143-145
9377579-4	1997	By deletion analysis and mutagenesis, we have identified the Ap1 site in the promoter as the cis element mediating transcriptional activation of elafin in 70N normal breast cells and its induction by phorbol 12-myristate 13-acetate (PMA) in 21MT2 breast tumors.	Tetradecanoylphorbol Acetate	233-236	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	61-64
9345320-4	1997	We next assessed the effect of silymarin on TPA- and OA-caused induction of mRNA expression of tumor necrosis factor alpha (TNF alpha) which is an endogenous tumor promoter and a central mediator of tumor promotion in vivo in the case of both TPA and OA tumor promotion.	Tetradecanoylphorbol Acetate	44-47	tumor necrosis factor	Mus musculus	95-122
9345320-4	1997	We next assessed the effect of silymarin on TPA- and OA-caused induction of mRNA expression of tumor necrosis factor alpha (TNF alpha) which is an endogenous tumor promoter and a central mediator of tumor promotion in vivo in the case of both TPA and OA tumor promotion.	Tetradecanoylphorbol Acetate	44-47	tumor necrosis factor	Mus musculus	124-133
9345320-4	1997	We next assessed the effect of silymarin on TPA- and OA-caused induction of mRNA expression of tumor necrosis factor alpha (TNF alpha) which is an endogenous tumor promoter and a central mediator of tumor promotion in vivo in the case of both TPA and OA tumor promotion.	Tetradecanoylphorbol Acetate	243-246	tumor necrosis factor	Mus musculus	95-122
9345320-4	1997	We next assessed the effect of silymarin on TPA- and OA-caused induction of mRNA expression of tumor necrosis factor alpha (TNF alpha) which is an endogenous tumor promoter and a central mediator of tumor promotion in vivo in the case of both TPA and OA tumor promotion.	Tetradecanoylphorbol Acetate	243-246	tumor necrosis factor	Mus musculus	124-133
9345320-5	1997	Topical application of silymarin on mouse skin prior to that of TPA or OA resulted in a highly significant to complete inhibition in a dose-dependent manner against both TPA- and OA-caused induction of TNF alpha mRNA expression in mouse epidermis.	Tetradecanoylphorbol Acetate	170-173	tumor necrosis factor	Mus musculus	202-211
9350346-2	1997	Phorbol myristate acetate (PMA), a PKC activator, stimulated fibronectin synthesis and its mRNA expression in both normal and transformed human lung fibroblasts (WI-38 and WI-38 VA13, respectively).	Tetradecanoylphorbol Acetate	27-30	fibronectin 1	Homo sapiens	61-72
9312114-7	1997	The role of the extracellular signal-related kinase (ERK) signaling pathway in the HMGI-C induction was highlighted by the result that the MAP kinase kinase (MEK) inhibitor, PD 98059, blocked DeltaRaf-1:ER- and 12-O-tetradecanoylphorbol-13-acetate-stimulated HMGI-C induction.	Tetradecanoylphorbol Acetate	211-247	Eph receptor B1	Rattus norvegicus	16-51
9312114-7	1997	The role of the extracellular signal-related kinase (ERK) signaling pathway in the HMGI-C induction was highlighted by the result that the MAP kinase kinase (MEK) inhibitor, PD 98059, blocked DeltaRaf-1:ER- and 12-O-tetradecanoylphorbol-13-acetate-stimulated HMGI-C induction.	Tetradecanoylphorbol Acetate	211-247	Eph receptor B1	Rattus norvegicus	53-56
9357764-1	1997	We have previously shown that a pretreatment with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), reduced deoxygenation-induced K+ loss and Ca2+ uptake and prevented cell dehydration in sickle anemia red blood cells (SS cells) (H. Fathallah, E. Coezy, R.-S. De Neef, M.-D. Hardy-Dessources, and F. Giraud.	Tetradecanoylphorbol Acetate	50-81	protein kinase C alpha	Homo sapiens	123-126
9357764-1	1997	We have previously shown that a pretreatment with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), reduced deoxygenation-induced K+ loss and Ca2+ uptake and prevented cell dehydration in sickle anemia red blood cells (SS cells) (H. Fathallah, E. Coezy, R.-S. De Neef, M.-D. Hardy-Dessources, and F. Giraud.	Tetradecanoylphorbol Acetate	83-86	protein kinase C alpha	Homo sapiens	123-126
9444384-5	1997	The PKC antagonists (H7, sphingosine) as well as RA downregulated the IFN-gamma-induced PNA-reactive gps, whereas staurosporine and TPA upregulated their expression.	Tetradecanoylphorbol Acetate	132-135	interferon gamma	Homo sapiens	70-79
9362243-4	1997	Phorbol 12-myristate 13-acetate (PMA) suppressed both Kv4.2 and Kv4.3 currents as well as native I(to), but not after preincubation with PKC inhibitors (e.g., chelerythrine).	Tetradecanoylphorbol Acetate	0-31	potassium voltage-gated channel subfamily D member 3	Rattus norvegicus	64-69
9362243-4	1997	Phorbol 12-myristate 13-acetate (PMA) suppressed both Kv4.2 and Kv4.3 currents as well as native I(to), but not after preincubation with PKC inhibitors (e.g., chelerythrine).	Tetradecanoylphorbol Acetate	33-36	potassium voltage-gated channel subfamily D member 3	Rattus norvegicus	64-69
9350346-2	1997	Phorbol myristate acetate (PMA), a PKC activator, stimulated fibronectin synthesis and its mRNA expression in both normal and transformed human lung fibroblasts (WI-38 and WI-38 VA13, respectively).	Tetradecanoylphorbol Acetate	0-25	fibronectin 1	Homo sapiens	61-72
9345355-1	1997	Previous studies from this laboratory have shown that epidermal growth factor (EGF) and the tumor promoter, phorbol myristate acetate (PMA), are mitogenic in the endometrial cancer cell line HEC-1-A.	Tetradecanoylphorbol Acetate	108-133	NDC80 kinetochore complex component	Homo sapiens	191-196
9368513-4	1997	The effects of dexamethasone and 17 beta-oestradiol on IL-1-, TNF-, TSH-, forskolin- and phorbol 12-myristate 13-acetate (PMA)-stimulated IL-6 release in serum-free conditions were studied in human thyrocytes derived from patients with Graves" disease and toxic multinodular goitres, and in the immortalised human thyrocyte cell line, HTori3.	Tetradecanoylphorbol Acetate	89-120	interleukin 6	Homo sapiens	138-142
9353133-2	1997	Phorbol ester (PMA), added to stimulate phosphorylation of P-gp by protein kinase C (PKC), caused a decrease in the cellular accumulation of DNR and VP-16, both in multidrug-resistant (MDR) P-gp-overexpressing cells and in wild-type cells.	Tetradecanoylphorbol Acetate	15-18	ATP binding cassette subfamily B member 1	Homo sapiens	59-63
9353133-2	1997	Phorbol ester (PMA), added to stimulate phosphorylation of P-gp by protein kinase C (PKC), caused a decrease in the cellular accumulation of DNR and VP-16, both in multidrug-resistant (MDR) P-gp-overexpressing cells and in wild-type cells.	Tetradecanoylphorbol Acetate	15-18	ATP binding cassette subfamily B member 1	Homo sapiens	190-194
9353133-6	1997	Therefore, Cal-AM was used to study the effect of PMA-induced phosphorylation of P-gp on its transport activity.	Tetradecanoylphorbol Acetate	50-53	ATP binding cassette subfamily B member 1	Homo sapiens	81-85
9353133-11	1997	However, these studies provide evidence that PMA-induced PKC activity decreases cellular drug accumulation in a P-gp-independent manner.	Tetradecanoylphorbol Acetate	45-48	ATP binding cassette subfamily B member 1	Homo sapiens	112-116
9375956-6	1997	Low levels of COX-2 and FLAP mRNA were expressed in undifferentiated THP-1 cells, but were induced upon differentiation of the cells along the monocytic pathway by treatment with phorbol ester (TPA, 5 nM).	Tetradecanoylphorbol Acetate	194-197	arachidonate 5-lipoxygenase activating protein	Homo sapiens	24-28
9368513-4	1997	The effects of dexamethasone and 17 beta-oestradiol on IL-1-, TNF-, TSH-, forskolin- and phorbol 12-myristate 13-acetate (PMA)-stimulated IL-6 release in serum-free conditions were studied in human thyrocytes derived from patients with Graves" disease and toxic multinodular goitres, and in the immortalised human thyrocyte cell line, HTori3.	Tetradecanoylphorbol Acetate	122-125	interleukin 6	Homo sapiens	138-142
9317114-7	1997	Nevertheless, PMA inhibits neither ICE activation nor the subsequent proteolysis of ICE substrates, suggesting that the PKC responsible for ICE inactivation is a non-PMA-sensitive PKC.	Tetradecanoylphorbol Acetate	166-169	proline rich transmembrane protein 2	Homo sapiens	120-123
9334853-2	1997	Naive CD4+CD45RA+ T-cells from human cord blood expressed CDw127 (IL-7R) at higher levels than adult CD4+ CD45RA+ T-cells and produced IL-2 and a small amount of IFN-gamma upon stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	194-197	CD4 molecule	Homo sapiens	6-9
9334853-2	1997	Naive CD4+CD45RA+ T-cells from human cord blood expressed CDw127 (IL-7R) at higher levels than adult CD4+ CD45RA+ T-cells and produced IL-2 and a small amount of IFN-gamma upon stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	194-197	interferon gamma	Homo sapiens	162-171
9329361-3	1997	Treatment of the amnion mesenchymal cells in serum-free medium with tetradecanoyl phorbol acetate (1 nM) caused an increase in the level of KGF mRNA.	Tetradecanoylphorbol Acetate	68-97	fibroblast growth factor 7	Homo sapiens	140-143
9355960-7	1997	The production of IL-4 and IgE was enhanced in the cells treated with 12-O-tetradecanoyl phorbol-13-acetate.	Tetradecanoylphorbol Acetate	70-107	interleukin 4	Homo sapiens	18-22
9333123-5	1997	Selective inhibition of protein kinase C (PKC) had no effect on the mechanoinduction of osteopontin even though opn has been demonstrated to be an early response gene to phorbol 12-myristate 13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	170-201	secreted phosphoprotein 1	Gallus gallus	112-115
9333123-5	1997	Selective inhibition of protein kinase C (PKC) had no effect on the mechanoinduction of osteopontin even though opn has been demonstrated to be an early response gene to phorbol 12-myristate 13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	203-206	secreted phosphoprotein 1	Gallus gallus	112-115
9317114-7	1997	Nevertheless, PMA inhibits neither ICE activation nor the subsequent proteolysis of ICE substrates, suggesting that the PKC responsible for ICE inactivation is a non-PMA-sensitive PKC.	Tetradecanoylphorbol Acetate	166-169	proline rich transmembrane protein 2	Homo sapiens	180-183
9317114-8	1997	In this system, Fas ligation also triggers Bcl-2/Bcl-x down-regulation, an effect inhibited by sIgG cross-linking, the cysteine protease inhibitor acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone, and PMA treatment.	Tetradecanoylphorbol Acetate	195-198	BCL2 apoptosis regulator	Homo sapiens	43-48
9317114-8	1997	In this system, Fas ligation also triggers Bcl-2/Bcl-x down-regulation, an effect inhibited by sIgG cross-linking, the cysteine protease inhibitor acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone, and PMA treatment.	Tetradecanoylphorbol Acetate	195-198	BCL2 like 1	Homo sapiens	49-54
9326362-3	1997	However, phorbol myristate acetate and the thymic peptide extract Thymex-L were able to enhance both the number of CD15-positive cells and the median fluorescence.	Tetradecanoylphorbol Acetate	9-34	fucosyltransferase 4	Homo sapiens	115-119
9364205-0	1997	Association of a murine chromosome 9 locus (Psl1) with susceptibility to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	103-139	promotion susceptibility QTL 1	Mus musculus	44-48
9364213-4	1997	bcl-2 overexpression in JB6 clone41 cells caused a TPA-induced soft-agar growth fivefold greater than the growth of nontransfected or vector-transfected (neo control) cells.	Tetradecanoylphorbol Acetate	51-54	BCL2 apoptosis regulator	Homo sapiens	0-5
9364213-7	1997	When compared with control cells, bcl-2-transfected cells expressed significantly more c-fos but not c-jun after TPA treatment.	Tetradecanoylphorbol Acetate	113-116	BCL2 apoptosis regulator	Homo sapiens	34-39
9364213-8	1997	Furthermore, the levels of AP-1 and AP-1-induced transactivation of TRE-CAT were greater in bcl-2-transfected cells than in control cells after TPA treatment.	Tetradecanoylphorbol Acetate	144-147	BCL2 apoptosis regulator	Homo sapiens	92-97
9326269-5	1997	Translocation of PKC alpha, epsilon, and theta from the cytosol to the membrane was seen after 10 min or 1.5 h of treatment with TPA.	Tetradecanoylphorbol Acetate	129-132	protein kinase C, alpha	Mus musculus	17-46
9326269-9	1997	Phosphoinositide hydrolysis induced by AlF4-, but not Ca2+ ionophores, was inhibited by a 10-min treatment with TPA.	Tetradecanoylphorbol Acetate	112-115	AF4/FMR2 family, member 4	Mus musculus	39-43
9380028-13	1997	However, short term treatment with PMA, which activated NF-kappaB, resulted in protection against menadione cytotoxicity.	Tetradecanoylphorbol Acetate	35-38	nuclear factor kappa B subunit 1	Homo sapiens	56-65
9359473-7	1997	On the phorbol 12-myristate, 13-acetate (PMA)-stimulated 3 beta-HSD-1, 17beta-HSD-1 and P450scc mRNA levels only the lowest concentration of A23187 potentialized the PMA effect on the 17 beta-HSD-1 mRNA levels.	Tetradecanoylphorbol Acetate	41-44	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	88-95
9359473-7	1997	On the phorbol 12-myristate, 13-acetate (PMA)-stimulated 3 beta-HSD-1, 17beta-HSD-1 and P450scc mRNA levels only the lowest concentration of A23187 potentialized the PMA effect on the 17 beta-HSD-1 mRNA levels.	Tetradecanoylphorbol Acetate	41-44	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	184-197
9295345-7	1997	Addition of a soluble form of LRP to cultured HepG2 cells resulted in a significant inhibition of capacity of these cells to degrade tPA, a process that has been demonstrated to be mediated by cell surface LRP.	Tetradecanoylphorbol Acetate	133-136	LDL receptor related protein 1	Homo sapiens	30-33
9295281-5	1997	We found that Bcl-2 levels were increased by treatment of HL-60 cells with exogenous DAG or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	92-128	BCL2 apoptosis regulator	Homo sapiens	14-19
9295281-5	1997	We found that Bcl-2 levels were increased by treatment of HL-60 cells with exogenous DAG or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	130-133	BCL2 apoptosis regulator	Homo sapiens	14-19
9295281-11	1997	ET-18-OCH3 also inhibited stimulation of Bcl-2 by TPA and enhanced the decrease in Bcl-2 observed in ara-C-treated cells.	Tetradecanoylphorbol Acetate	50-53	BCL2 apoptosis regulator	Homo sapiens	41-46
9333019-4	1997	We also observed that in E5-expressing cells, treatment with PMA results in an increase in membrane-associated PKC activity, and a superactivation of the ERK1/2 MAP kinases.	Tetradecanoylphorbol Acetate	61-64	mitogen-activated protein kinase 3	Homo sapiens	154-160
9299495-1	1997	Transcription factor AP-1 induced by 12-O-tetradecanoylphorbol-13-acetate treatment of LLC-PK1 cells binds specifically to an AP-1 oligonucleotide.	Tetradecanoylphorbol Acetate	37-73	transcription factor Jun	Sus scrofa	21-25
9333019-6	1997	Furthermore, treatment with genistein strongly reduces the PMA-mediated superactivation of ERK1/2 kinases, demonstrating a PKC-mediated, tyrosine kinase-dependent pathway in the superinduction of MAP kinase activation.	Tetradecanoylphorbol Acetate	59-62	mitogen-activated protein kinase 3	Homo sapiens	91-97
9298128-1	1997	The in vitro growth of human hair follicles is inhibited by interleukin (IL)-1 beta and phorbol esters, such as phorbol-myristate-acetate (PMA), but enhanced by insulin-like growth factor (IGF)-I.	Tetradecanoylphorbol Acetate	139-142	interleukin 1 beta	Homo sapiens	60-83
9287350-4	1997	TPA, a differentiation inducer, caused sustained activation of ERK (&gt;24 h), whereas bryostatin, a differentiation blocker, only transiently activated ERK ( approximately 6 h) and attenuated the activation of ERK by TPA.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	63-66
9316415-5	1997	Treatment with PMA for 30 min increased PKC activity in subcellular fractions and induced a redistribution of PKC-beta II and -delta to a particulate fraction.	Tetradecanoylphorbol Acetate	15-18	protein kinase C alpha	Homo sapiens	40-43
9395008-1	1997	The purpose of this study is to elucidate the effect of interleukin-7 (IL-7) and soluble CD23 (sCD23) on Phorbol12 Myristate13 Acetate (PMA) activated CD4+ TCR alpha beta+ cells of HIV-1 infected subjects.	Tetradecanoylphorbol Acetate	105-134	interleukin 7	Homo sapiens	71-75
9395008-1	1997	The purpose of this study is to elucidate the effect of interleukin-7 (IL-7) and soluble CD23 (sCD23) on Phorbol12 Myristate13 Acetate (PMA) activated CD4+ TCR alpha beta+ cells of HIV-1 infected subjects.	Tetradecanoylphorbol Acetate	105-134	CD4 molecule	Homo sapiens	151-154
9395008-1	1997	The purpose of this study is to elucidate the effect of interleukin-7 (IL-7) and soluble CD23 (sCD23) on Phorbol12 Myristate13 Acetate (PMA) activated CD4+ TCR alpha beta+ cells of HIV-1 infected subjects.	Tetradecanoylphorbol Acetate	136-139	interleukin 7	Homo sapiens	71-75
9395008-1	1997	The purpose of this study is to elucidate the effect of interleukin-7 (IL-7) and soluble CD23 (sCD23) on Phorbol12 Myristate13 Acetate (PMA) activated CD4+ TCR alpha beta+ cells of HIV-1 infected subjects.	Tetradecanoylphorbol Acetate	136-139	CD4 molecule	Homo sapiens	151-154
9328180-1	1997	Phorbol ester-sensitive EL4 murine thymoma cells respond to phorbol 12-myristate 13-acetate with activation of ERK mitogen-activated protein kinases, synthesis of interleukin-2, and death, whereas phorbol ester-resistant variants of this cell line do not exhibit these responses.	Tetradecanoylphorbol Acetate	60-91	mitogen-activated protein kinase 1	Mus musculus	111-114
9300182-7	1997	In addition, FGF-1.C mRNA also increases significantly (more than 100-fold) in response to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	91-122	fibroblast growth factor 1	Homo sapiens	13-18
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Tetradecanoylphorbol Acetate	135-160	Fas (TNF receptor superfamily member 6)	Mus musculus	23-27
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Tetradecanoylphorbol Acetate	135-160	Fc receptor, IgG, low affinity III	Mus musculus	50-62
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Tetradecanoylphorbol Acetate	135-160	Fas (TNF receptor superfamily member 6)	Mus musculus	175-179
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Tetradecanoylphorbol Acetate	135-160	Fc receptor, IgG, low affinity III	Mus musculus	213-225
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Tetradecanoylphorbol Acetate	135-160	Fas (TNF receptor superfamily member 6)	Mus musculus	175-179
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Tetradecanoylphorbol Acetate	135-160	Fc receptor, IgG, low affinity III	Mus musculus	213-225
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Tetradecanoylphorbol Acetate	162-165	Fas (TNF receptor superfamily member 6)	Mus musculus	23-27
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Tetradecanoylphorbol Acetate	162-165	Fc receptor, IgG, low affinity III	Mus musculus	50-62
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Tetradecanoylphorbol Acetate	162-165	Fas (TNF receptor superfamily member 6)	Mus musculus	175-179
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Tetradecanoylphorbol Acetate	162-165	Fc receptor, IgG, low affinity III	Mus musculus	213-225
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Tetradecanoylphorbol Acetate	162-165	Fas (TNF receptor superfamily member 6)	Mus musculus	175-179
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Tetradecanoylphorbol Acetate	162-165	Fc receptor, IgG, low affinity III	Mus musculus	213-225
9350434-1	1997	Double-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	85-110	nuclear factor kappa B subunit 1	Homo sapiens	133-143
9285638-7	1997	The effect of glucose and TPA was totally reversed by preincubating the cells with the PKC inhibitors staurosporine (10(-8) mol/L) and Goe 6976 (10(-8) mol/L).	Tetradecanoylphorbol Acetate	26-29	proline rich transmembrane protein 2	Homo sapiens	87-90
9285638-8	1997	Downregulation of PKC by preincubation with TPA for 24 hours also abolished the effect of glucose and TPA on endothelial cell permeability.	Tetradecanoylphorbol Acetate	44-47	proline rich transmembrane protein 2	Homo sapiens	18-21
9285638-8	1997	Downregulation of PKC by preincubation with TPA for 24 hours also abolished the effect of glucose and TPA on endothelial cell permeability.	Tetradecanoylphorbol Acetate	102-105	proline rich transmembrane protein 2	Homo sapiens	18-21
9285638-12	1997	Specific antisense oligodesoxynucleotides (ODNs) against PKC alpha reduced the expression of the isoform, abolished the effects of glucose on endothelial cell permeability completely, and reduced the TPA effect significantly.	Tetradecanoylphorbol Acetate	200-203	protein kinase C alpha	Homo sapiens	57-66
9346296-2	1997	In the present study, performed in cell-free preparations, we have characterized and compared the regulation of HEK cell PLD activity by the stable GTP analogue, guanosine 5"-O-[gamma-thio]triphosphate (GTP[S]), and the phorbol ester, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	235-266	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	121-124
9346296-2	1997	In the present study, performed in cell-free preparations, we have characterized and compared the regulation of HEK cell PLD activity by the stable GTP analogue, guanosine 5"-O-[gamma-thio]triphosphate (GTP[S]), and the phorbol ester, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	268-271	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	121-124
9346296-5	1997	GDP and its analogue, guanosine 5"-O-[beta-thio]diphosphate, inhibited the stimulatory effect of GTP[S], whereas the PMA response was prevented by the nonselective PKC inhibitor, staurosporine, but not vice versa.	Tetradecanoylphorbol Acetate	117-120	protein kinase C alpha	Homo sapiens	164-167
9285484-10	1997	Up-regulation of PKC by 10(-6) M phorbol-12-myristate-13-acetate (PMA) had no effect on the L-type current amplitude.	Tetradecanoylphorbol Acetate	33-64	proline rich transmembrane protein 2	Homo sapiens	17-20
9285484-10	1997	Up-regulation of PKC by 10(-6) M phorbol-12-myristate-13-acetate (PMA) had no effect on the L-type current amplitude.	Tetradecanoylphorbol Acetate	66-69	proline rich transmembrane protein 2	Homo sapiens	17-20
9285485-6	1997	Transfection of one mutant clone with a functional endopeptidase 24.11 restored in a significant manner PMA-induced growth arrest in all the clones selected and tested, whereas transfection of an inactive form of endopeptidase 24.11 had no effect, demonstrating that the enzymatic activity of CD10 is critical in the mediation of the PMA growth arrest.	Tetradecanoylphorbol Acetate	104-107	membrane metalloendopeptidase	Homo sapiens	293-297
9350434-2	1997	Since these latter compounds were known to activate NF-kappa B translocation in a redox-sensitive way, we have demonstrated that NF-kappa B activation by PMA was resistant to antioxidant N-acetyl-L-cysteine (NAC) and sensitive to kinase inhibitors staurosporine and H7 while activation by H2O2 or TNF-alpha were not.	Tetradecanoylphorbol Acetate	154-157	nuclear factor kappa B subunit 1	Homo sapiens	52-62
9350434-2	1997	Since these latter compounds were known to activate NF-kappa B translocation in a redox-sensitive way, we have demonstrated that NF-kappa B activation by PMA was resistant to antioxidant N-acetyl-L-cysteine (NAC) and sensitive to kinase inhibitors staurosporine and H7 while activation by H2O2 or TNF-alpha were not.	Tetradecanoylphorbol Acetate	154-157	nuclear factor kappa B subunit 1	Homo sapiens	129-139
9350434-2	1997	Since these latter compounds were known to activate NF-kappa B translocation in a redox-sensitive way, we have demonstrated that NF-kappa B activation by PMA was resistant to antioxidant N-acetyl-L-cysteine (NAC) and sensitive to kinase inhibitors staurosporine and H7 while activation by H2O2 or TNF-alpha were not.	Tetradecanoylphorbol Acetate	154-157	tumor necrosis factor	Homo sapiens	297-306
9350434-1	1997	Double-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	85-110	tumor necrosis factor	Homo sapiens	290-317
9350434-1	1997	Double-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	85-110	tumor necrosis factor	Homo sapiens	319-328
9350434-1	1997	Double-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	112-115	nuclear factor kappa B subunit 1	Homo sapiens	133-143
9350434-1	1997	Double-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	112-115	tumor necrosis factor	Homo sapiens	290-317
9350434-1	1997	Double-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	112-115	tumor necrosis factor	Homo sapiens	319-328
9378778-5	1997	In both BME and BAE cells, antibodies to bFGF also decreased basal levels of cell-associated uPA activity, and completely blocked the VEGF-mediated increase in uPA and tPA expression observed in parallel cultures incubated with VEGF alone.	Tetradecanoylphorbol Acetate	168-171	fibroblast growth factor 2	Bos taurus	41-45
9342616-2	1997	Neutrophils contain a 21-kDa phosphoprotein that undergoes rapid dephosphorylation upon stimulation of these cells with the chemoattractant N-fMet-Leu-Phe (fMLP), activators of protein kinase C [e.g., 4 beta-phorbol 12-myristate 13-acetate (PMA)] or the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	203-239	formyl peptide receptor 1	Homo sapiens	140-154
9342616-2	1997	Neutrophils contain a 21-kDa phosphoprotein that undergoes rapid dephosphorylation upon stimulation of these cells with the chemoattractant N-fMet-Leu-Phe (fMLP), activators of protein kinase C [e.g., 4 beta-phorbol 12-myristate 13-acetate (PMA)] or the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	203-239	formyl peptide receptor 1	Homo sapiens	156-160
9342616-2	1997	Neutrophils contain a 21-kDa phosphoprotein that undergoes rapid dephosphorylation upon stimulation of these cells with the chemoattractant N-fMet-Leu-Phe (fMLP), activators of protein kinase C [e.g., 4 beta-phorbol 12-myristate 13-acetate (PMA)] or the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	241-244	formyl peptide receptor 1	Homo sapiens	140-154
9342616-2	1997	Neutrophils contain a 21-kDa phosphoprotein that undergoes rapid dephosphorylation upon stimulation of these cells with the chemoattractant N-fMet-Leu-Phe (fMLP), activators of protein kinase C [e.g., 4 beta-phorbol 12-myristate 13-acetate (PMA)] or the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	241-244	formyl peptide receptor 1	Homo sapiens	156-160
9288167-2	1997	A structure-activity relationship study of the N-phenylphthalimides and N-benzylphthalimides revealed that their enhancing effect on TPA-induced TNF-alpha production by HL-60 cells and their inhibiting effect on OA-induced TNF-alpha production by HL-60 cells are only partially correlated.	Tetradecanoylphorbol Acetate	133-136	tumor necrosis factor	Homo sapiens	145-154
9307240-3	1997	Cultured human monocytic THP-1 cells increased their glutamate secretion following 18 and 68 h exposure to the inflammatory mediators zymosan, phorbol myristate acetate (PMA), lipopolysaccharide, interferon-gamma, tumor-necrosis factor-alpha and interleukin-1beta.	Tetradecanoylphorbol Acetate	143-168	GLI family zinc finger 2	Homo sapiens	25-30
9307240-3	1997	Cultured human monocytic THP-1 cells increased their glutamate secretion following 18 and 68 h exposure to the inflammatory mediators zymosan, phorbol myristate acetate (PMA), lipopolysaccharide, interferon-gamma, tumor-necrosis factor-alpha and interleukin-1beta.	Tetradecanoylphorbol Acetate	170-173	GLI family zinc finger 2	Homo sapiens	25-30
9328437-9	1997	Fewer papillomas (P &lt; 0.05) were observed at the low dose of TPA (1.25 microg) in mice carrying the bcl-2 knockout allele than in the wild-type mice, suggesting that reduction of the bcl-2 gene product affects the susceptibility of TG.AC mice to TPA-induced papillomas.	Tetradecanoylphorbol Acetate	64-67	B cell leukemia/lymphoma 2	Mus musculus	103-108
9328437-9	1997	Fewer papillomas (P &lt; 0.05) were observed at the low dose of TPA (1.25 microg) in mice carrying the bcl-2 knockout allele than in the wild-type mice, suggesting that reduction of the bcl-2 gene product affects the susceptibility of TG.AC mice to TPA-induced papillomas.	Tetradecanoylphorbol Acetate	64-67	B cell leukemia/lymphoma 2	Mus musculus	186-191
9328437-11	1997	This suggests that at the higher dose of TPA, the effect of reduction in bcl-2 gene product was obscured.	Tetradecanoylphorbol Acetate	41-44	B cell leukemia/lymphoma 2	Mus musculus	73-78
9299393-2	1997	The infectivity of HIV-1 from the cells stimulated with phorbol 12-myristate 13-acetate (PMA) was suppressed by pretreatment with N-myristoyl glycinal diethylacetal (N-Myr-GOA), a potent N-myristoylation inhibitor, and the blockage of myristoylation resulted in accumulation of immature gag precursors.	Tetradecanoylphorbol Acetate	56-87	tripartite motif containing 47	Homo sapiens	172-175
9299393-2	1997	The infectivity of HIV-1 from the cells stimulated with phorbol 12-myristate 13-acetate (PMA) was suppressed by pretreatment with N-myristoyl glycinal diethylacetal (N-Myr-GOA), a potent N-myristoylation inhibitor, and the blockage of myristoylation resulted in accumulation of immature gag precursors.	Tetradecanoylphorbol Acetate	89-92	tripartite motif containing 47	Homo sapiens	172-175
9288167-2	1997	A structure-activity relationship study of the N-phenylphthalimides and N-benzylphthalimides revealed that their enhancing effect on TPA-induced TNF-alpha production by HL-60 cells and their inhibiting effect on OA-induced TNF-alpha production by HL-60 cells are only partially correlated.	Tetradecanoylphorbol Acetate	133-136	tumor necrosis factor	Homo sapiens	223-232
9281358-7	1997	Activation of PKC by phorbol myristate acetate (PMA) also resulted in increased Il6 gene expression by control and CSF-1-primed PMo.	Tetradecanoylphorbol Acetate	21-46	interleukin 6	Mus musculus	80-83
9261139-9	1997	While phorbol 12-myristate 13-acetate produced rapid activation of pp90(rsk), in vivo, other potent NF-kappaB inducers, including tumor necrosis factor alpha and the Tax transactivator of human T-cell lymphotrophic virus, type I, failed to activate pp90(rsk).	Tetradecanoylphorbol Acetate	6-37	ribosomal protein S6 kinase A2	Homo sapiens	72-75
9281615-10	1997	Both 6-beta-[beta"(piperidino)propionyl]forskolin and phorbol-12-myristate-13-acetate increased [3H]cytisine binding sites and nAChR function and enhanced the effects of chronic (-)-nicotine treatment in a synergistic manner.	Tetradecanoylphorbol Acetate	54-85	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	127-132
9261131-7	1997	Meanwhile, activation of protein kinase C by 12-O-tetradecanoylphorbol acetate (TPA) markedly decreased the level of IRK1 mRNA, which required ongoing protein synthesis.	Tetradecanoylphorbol Acetate	45-78	potassium inwardly-rectifying channel, subfamily J, member 2	Mus musculus	117-121
9261131-7	1997	Meanwhile, activation of protein kinase C by 12-O-tetradecanoylphorbol acetate (TPA) markedly decreased the level of IRK1 mRNA, which required ongoing protein synthesis.	Tetradecanoylphorbol Acetate	80-83	potassium inwardly-rectifying channel, subfamily J, member 2	Mus musculus	117-121
9261139-9	1997	While phorbol 12-myristate 13-acetate produced rapid activation of pp90(rsk), in vivo, other potent NF-kappaB inducers, including tumor necrosis factor alpha and the Tax transactivator of human T-cell lymphotrophic virus, type I, failed to activate pp90(rsk).	Tetradecanoylphorbol Acetate	6-37	ribosomal protein S6 kinase A2	Homo sapiens	254-257
9261131-8	1997	Actinomycin D experiments revealed that ionomycin increased the half-life of IRK1 mRNA from 0.86 to 1.97 h, but TPA decreased it to 0.38 h. However, neither ionomycin nor TPA appreciably altered the rate of IRK1 gene transcription.	Tetradecanoylphorbol Acetate	112-115	potassium inwardly-rectifying channel, subfamily J, member 2	Mus musculus	207-211
9295164-0	1997	Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells.	Tetradecanoylphorbol Acetate	0-25	phospholipase D1	Rattus norvegicus	79-95
9296525-1	1997	Erythroid differentiation of normal human hematopoietic progenitor cells was drastically inhibited by phorbol ester, 12-myristate 13-acetate (PMA), an agent known to activate the class of serine-threonine kinases, protein kinase C (PKC).	Tetradecanoylphorbol Acetate	142-145	proline rich transmembrane protein 2	Homo sapiens	214-230
9296525-1	1997	Erythroid differentiation of normal human hematopoietic progenitor cells was drastically inhibited by phorbol ester, 12-myristate 13-acetate (PMA), an agent known to activate the class of serine-threonine kinases, protein kinase C (PKC).	Tetradecanoylphorbol Acetate	142-145	proline rich transmembrane protein 2	Homo sapiens	232-235
9295164-2	1997	We found that protein kinase C alp (PKCalpha) stimulated PLD1 activity in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	90-115	phospholipase D1	Rattus norvegicus	57-61
9295164-2	1997	We found that protein kinase C alp (PKCalpha) stimulated PLD1 activity in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	117-120	phospholipase D1	Rattus norvegicus	57-61
9313776-2	1997	NPY/SRIF production in response to brain-derived neurotrophic factor (BDNF) or phorbol-12-myristate-13-acetate (PMA) was used as a functional criterion.	Tetradecanoylphorbol Acetate	79-110	neuropeptide Y	Rattus norvegicus	0-3
9277481-2	1997	AT1 mRNA expression in cultured bovine VSMC increased twofold after 8 h of protein kinase C (PKC) activation with phorbol 12-myristate 13-acetate (PMA), whereas stimulation with forskolin did not alter the AT1 mRNA level.	Tetradecanoylphorbol Acetate	114-145	angiotensin II receptor type 1	Bos taurus	0-3
9252399-3	1997	Responsiveness to 12-O-tetradecanoylphorbol-13-acetate (TPA) localized to the SP-B proximal promoter (-140/-65 bp) and specifically to binding sites for TTF-1 and HNF3, which act as cell-specific enhancers of SP-B expression.	Tetradecanoylphorbol Acetate	18-54	NK2 homeobox 1	Homo sapiens	153-158
9252399-3	1997	Responsiveness to 12-O-tetradecanoylphorbol-13-acetate (TPA) localized to the SP-B proximal promoter (-140/-65 bp) and specifically to binding sites for TTF-1 and HNF3, which act as cell-specific enhancers of SP-B expression.	Tetradecanoylphorbol Acetate	56-59	NK2 homeobox 1	Homo sapiens	153-158
9252399-4	1997	Treatment of cells with TPA (10 nM) caused a time-dependent decrease in both TTF-1 and HNF3 in nuclear extracts and accumulation of both factors in the cytoplasm as assessed by electromobility shift, Western, Southwestern, and immunofluorescence assays.	Tetradecanoylphorbol Acetate	24-27	NK2 homeobox 1	Homo sapiens	77-82
9245795-5	1997	Induction of LAR processing by TPA in 293 cells did require overexpression of PKCalpha.	Tetradecanoylphorbol Acetate	31-34	protein tyrosine phosphatase receptor type F	Homo sapiens	13-16
9245795-5	1997	Induction of LAR processing by TPA in 293 cells did require overexpression of PKCalpha.	Tetradecanoylphorbol Acetate	31-34	protein kinase C alpha	Homo sapiens	78-86
9277481-2	1997	AT1 mRNA expression in cultured bovine VSMC increased twofold after 8 h of protein kinase C (PKC) activation with phorbol 12-myristate 13-acetate (PMA), whereas stimulation with forskolin did not alter the AT1 mRNA level.	Tetradecanoylphorbol Acetate	114-145	proline rich transmembrane protein 2	Homo sapiens	93-96
9277481-2	1997	AT1 mRNA expression in cultured bovine VSMC increased twofold after 8 h of protein kinase C (PKC) activation with phorbol 12-myristate 13-acetate (PMA), whereas stimulation with forskolin did not alter the AT1 mRNA level.	Tetradecanoylphorbol Acetate	147-150	angiotensin II receptor type 1	Bos taurus	0-3
9277481-2	1997	AT1 mRNA expression in cultured bovine VSMC increased twofold after 8 h of protein kinase C (PKC) activation with phorbol 12-myristate 13-acetate (PMA), whereas stimulation with forskolin did not alter the AT1 mRNA level.	Tetradecanoylphorbol Acetate	147-150	proline rich transmembrane protein 2	Homo sapiens	93-96
15989666-3	1997	Since alteplase is an approved pharmaceutical name, the term tPA will be used to refer to the naturally occurring substance in its physiological context.	Tetradecanoylphorbol Acetate	61-64	plasminogen activator, tissue type	Homo sapiens	6-15
9242444-5	1997	Surface biotinylation and immunoprecipitation with anti-MMP-9 antibodies revealed the presence of two MMP-9 forms (M(r) 92,000 and 85,000) on the surface of TPA-treated MCF10A cells, whereas in the media, only the M(r) 92,000 form was detected, mostly in complex with TIMP-1, a specific MMP-9 inhibitor.	Tetradecanoylphorbol Acetate	157-160	TIMP metallopeptidase inhibitor 1	Homo sapiens	268-274
9242444-10	1997	These studies demonstrate a specific cell surface association of MMP-9 in response to TPA that may help to localize TIMP-1-free enzyme on the surface of breast epithelial cells.	Tetradecanoylphorbol Acetate	86-89	TIMP metallopeptidase inhibitor 1	Homo sapiens	116-122
9260891-3	1997	Down-regulation of PKC by prolonged treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) also blocks induction of 2-5A synthetase mRNAs and decreases both constitutive and IFN-alpha-induced enzymatic activity.	Tetradecanoylphorbol Acetate	51-87	proline rich transmembrane protein 2	Homo sapiens	19-22
9260891-3	1997	Down-regulation of PKC by prolonged treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) also blocks induction of 2-5A synthetase mRNAs and decreases both constitutive and IFN-alpha-induced enzymatic activity.	Tetradecanoylphorbol Acetate	51-87	interferon alpha 1	Homo sapiens	177-186
9260891-3	1997	Down-regulation of PKC by prolonged treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) also blocks induction of 2-5A synthetase mRNAs and decreases both constitutive and IFN-alpha-induced enzymatic activity.	Tetradecanoylphorbol Acetate	89-92	proline rich transmembrane protein 2	Homo sapiens	19-22
9260891-3	1997	Down-regulation of PKC by prolonged treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) also blocks induction of 2-5A synthetase mRNAs and decreases both constitutive and IFN-alpha-induced enzymatic activity.	Tetradecanoylphorbol Acetate	89-92	interferon alpha 1	Homo sapiens	177-186
9260891-4	1997	Cotreatment of cells with TPA and IFN-alpha increases induction of 2-5A synthetase mRNAs above that seen in cells treated with IFN-alpha alone.	Tetradecanoylphorbol Acetate	26-29	interferon alpha 1	Homo sapiens	127-136
9260900-0	1997	Differential regulation of extracellular signal-regulated kinase 1 and 2 activity during 12-O-tetradecanoylphorbol 13-acetate-induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	89-125	mitogen-activated protein kinase 3	Homo sapiens	27-72
9260900-1	1997	In this study we have analyzed short- and long-term changes in extracellular signal-regulated kinase (ERK) 1 and 2 activity during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of human promyelocytic leukemia cells.	Tetradecanoylphorbol Acetate	131-167	mitogen-activated protein kinase 3	Homo sapiens	63-114
9260900-1	1997	In this study we have analyzed short- and long-term changes in extracellular signal-regulated kinase (ERK) 1 and 2 activity during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of human promyelocytic leukemia cells.	Tetradecanoylphorbol Acetate	169-172	mitogen-activated protein kinase 3	Homo sapiens	63-114
9260900-9	1997	These results also indicate that ERK1 and ERK2 are regulated by distinct mechanisms during TPA-induced HL-60 differentiation, suggesting that their biological roles are nonredundant.	Tetradecanoylphorbol Acetate	91-94	mitogen-activated protein kinase 3	Homo sapiens	33-37
9260900-9	1997	These results also indicate that ERK1 and ERK2 are regulated by distinct mechanisms during TPA-induced HL-60 differentiation, suggesting that their biological roles are nonredundant.	Tetradecanoylphorbol Acetate	91-94	mitogen-activated protein kinase 1	Homo sapiens	42-46
9242548-7	1997	After differentiation with phorbol-12-myristate-13-acetate (PMA), iNOS transfectants produced more tumor necrosis factor-alpha (TNF-alpha) (124.9 +/- 25.4 pg/5 x 10(5) cells per 24 hours) than did empty-vector transfected cells (21.9 +/- 1.9 pg/5 x 10(5) cells per 24 hours; P = .02).	Tetradecanoylphorbol Acetate	27-58	nitric oxide synthase 2	Rattus norvegicus	66-70
9242548-7	1997	After differentiation with phorbol-12-myristate-13-acetate (PMA), iNOS transfectants produced more tumor necrosis factor-alpha (TNF-alpha) (124.9 +/- 25.4 pg/5 x 10(5) cells per 24 hours) than did empty-vector transfected cells (21.9 +/- 1.9 pg/5 x 10(5) cells per 24 hours; P = .02).	Tetradecanoylphorbol Acetate	60-63	nitric oxide synthase 2	Rattus norvegicus	66-70
9245485-5	1997	We also observed that the addition of the tumour-promoting phorbol ester, Phorbol 12-myristate 13-acetate (PMA), downregulated PKC-alpha, delta and epsilon by 7 h in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	74-105	protein kinase C, alpha	Mus musculus	127-136
9245485-5	1997	We also observed that the addition of the tumour-promoting phorbol ester, Phorbol 12-myristate 13-acetate (PMA), downregulated PKC-alpha, delta and epsilon by 7 h in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	107-110	protein kinase C, alpha	Mus musculus	127-136
9293391-7	1997	TPA-induced TNF-alpha and IL-8 release from keratinocytes.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	12-21
9293391-7	1997	TPA-induced TNF-alpha and IL-8 release from keratinocytes.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
9293391-9	1997	TPA increased RNA expression of the TNF-alpha, IL-1 alpha, IL-1 beta, IL-8 and TGF-beta 1.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	36-45
9293391-9	1997	TPA increased RNA expression of the TNF-alpha, IL-1 alpha, IL-1 beta, IL-8 and TGF-beta 1.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Homo sapiens	59-68
9293391-9	1997	TPA increased RNA expression of the TNF-alpha, IL-1 alpha, IL-1 beta, IL-8 and TGF-beta 1.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
9293391-9	1997	TPA increased RNA expression of the TNF-alpha, IL-1 alpha, IL-1 beta, IL-8 and TGF-beta 1.	Tetradecanoylphorbol Acetate	0-3	transforming growth factor beta 1	Homo sapiens	79-89
9293391-10	1997	BC diminished TPA-induced TNF-alpha and IL-8 release from keratinocytes; in the case of IL-8 it is possible that this inhibition occur to transcriptional level.	Tetradecanoylphorbol Acetate	14-17	tumor necrosis factor	Homo sapiens	26-35
9293391-10	1997	BC diminished TPA-induced TNF-alpha and IL-8 release from keratinocytes; in the case of IL-8 it is possible that this inhibition occur to transcriptional level.	Tetradecanoylphorbol Acetate	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
9234795-4	1997	The results demonstrate that class I and II protein kinase C (PKC) isozymes are required for sensitization of HUVEC to Shiga toxin by phorbol myristate acetate (PMA) or LPS but not by TNF or IL-1.	Tetradecanoylphorbol Acetate	134-159	proline rich transmembrane protein 2	Homo sapiens	44-60
9234795-4	1997	The results demonstrate that class I and II protein kinase C (PKC) isozymes are required for sensitization of HUVEC to Shiga toxin by phorbol myristate acetate (PMA) or LPS but not by TNF or IL-1.	Tetradecanoylphorbol Acetate	134-159	proline rich transmembrane protein 2	Homo sapiens	62-65
9234795-4	1997	The results demonstrate that class I and II protein kinase C (PKC) isozymes are required for sensitization of HUVEC to Shiga toxin by phorbol myristate acetate (PMA) or LPS but not by TNF or IL-1.	Tetradecanoylphorbol Acetate	161-164	proline rich transmembrane protein 2	Homo sapiens	44-60
9234795-4	1997	The results demonstrate that class I and II protein kinase C (PKC) isozymes are required for sensitization of HUVEC to Shiga toxin by phorbol myristate acetate (PMA) or LPS but not by TNF or IL-1.	Tetradecanoylphorbol Acetate	161-164	proline rich transmembrane protein 2	Homo sapiens	62-65
9234795-5	1997	Thus, the specific competitive inhibitor of class I/II PKC, 1-O-hexadecyl-2-O-methyl-rac-glycerol (AMG), prevented only the action of PMA and LPS on HUVEC.	Tetradecanoylphorbol Acetate	134-137	proline rich transmembrane protein 2	Homo sapiens	55-58
9280203-5	1997	The activation of ANP-C receptor by C-ANP(4-23) (a ring-deleted peptide of ANP) and C-type natriuretic peptide inhibits the mitogen-activated protein kinase activity stimulated by endothelin-3, platelet-derived growth factor and phorbol-12 myristate 13-acetate.	Tetradecanoylphorbol Acetate	229-260	natriuretic peptide A	Homo sapiens	18-21
9568551-1	1997	This study describes the activation conditions for tumor necrosis factor-alpha (TNF alpha) production in myelomonocytic U937 cells and human primary peripheral blood monocytes in response to lipopolysaccharide (LPS) and/or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	223-254	tumor necrosis factor	Homo sapiens	51-78
9568551-1	1997	This study describes the activation conditions for tumor necrosis factor-alpha (TNF alpha) production in myelomonocytic U937 cells and human primary peripheral blood monocytes in response to lipopolysaccharide (LPS) and/or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	223-254	tumor necrosis factor	Homo sapiens	80-89
9568551-1	1997	This study describes the activation conditions for tumor necrosis factor-alpha (TNF alpha) production in myelomonocytic U937 cells and human primary peripheral blood monocytes in response to lipopolysaccharide (LPS) and/or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	256-259	tumor necrosis factor	Homo sapiens	51-78
9568551-1	1997	This study describes the activation conditions for tumor necrosis factor-alpha (TNF alpha) production in myelomonocytic U937 cells and human primary peripheral blood monocytes in response to lipopolysaccharide (LPS) and/or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	256-259	tumor necrosis factor	Homo sapiens	80-89
9258746-4	1997	The early (&lt; 1 h) inhibition by TPA was consistent with an increase in the phosphorylation of connexin 43 (Cx43).	Tetradecanoylphorbol Acetate	35-38	gap junction protein, alpha 1	Mus musculus	97-108
9258746-4	1997	The early (&lt; 1 h) inhibition by TPA was consistent with an increase in the phosphorylation of connexin 43 (Cx43).	Tetradecanoylphorbol Acetate	35-38	gap junction protein, alpha 1	Mus musculus	110-114
9281445-6	1997	Consistent with their known properties, treatment with ST reduced, and combined treatment with TPA and ST increased, the level of 32P-incorporation into Cx43.	Tetradecanoylphorbol Acetate	95-98	gap junction protein, alpha 1	Rattus norvegicus	153-157
9281445-7	1997	Two-dimensional tryptic phosphopeptide maps of 32P-labeled Cx43 indicated that a distinct subset of the phosphopeptides that are present under basal conditions were affected by ST or ST/TPA treatments, with TPA-induced phosphorylation occurring at the ST-sensitive sites.	Tetradecanoylphorbol Acetate	186-189	gap junction protein, alpha 1	Rattus norvegicus	59-63
9568551-4	1997	In contrast to the effect on TNF alpha production, PMA induced strong phosphorylation/activation of p42/p44mapk in monocytes by 10 min determined in a mobility shift assay, while LPS was a weaker inducer.	Tetradecanoylphorbol Acetate	51-54	cyclin dependent kinase like 1	Homo sapiens	100-103
9568551-4	1997	In contrast to the effect on TNF alpha production, PMA induced strong phosphorylation/activation of p42/p44mapk in monocytes by 10 min determined in a mobility shift assay, while LPS was a weaker inducer.	Tetradecanoylphorbol Acetate	51-54	mitogen-activated protein kinase 3	Homo sapiens	104-111
9281445-7	1997	Two-dimensional tryptic phosphopeptide maps of 32P-labeled Cx43 indicated that a distinct subset of the phosphopeptides that are present under basal conditions were affected by ST or ST/TPA treatments, with TPA-induced phosphorylation occurring at the ST-sensitive sites.	Tetradecanoylphorbol Acetate	207-210	gap junction protein, alpha 1	Rattus norvegicus	59-63
9280203-5	1997	The activation of ANP-C receptor by C-ANP(4-23) (a ring-deleted peptide of ANP) and C-type natriuretic peptide inhibits the mitogen-activated protein kinase activity stimulated by endothelin-3, platelet-derived growth factor and phorbol-12 myristate 13-acetate.	Tetradecanoylphorbol Acetate	229-260	natriuretic peptide A	Homo sapiens	38-41
9280203-5	1997	The activation of ANP-C receptor by C-ANP(4-23) (a ring-deleted peptide of ANP) and C-type natriuretic peptide inhibits the mitogen-activated protein kinase activity stimulated by endothelin-3, platelet-derived growth factor and phorbol-12 myristate 13-acetate.	Tetradecanoylphorbol Acetate	229-260	natriuretic peptide A	Homo sapiens	38-41
9307112-13	1997	The activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) increases the amplitude of the Ca2+ current, diminishes facilitation, and reduces the inhibition of this current by UK14304 and VIP.	Tetradecanoylphorbol Acetate	46-77	vasoactive intestinal peptide	Rattus norvegicus	212-215
9307131-7	1997	Similar to the action of Ang II, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA, 100 nM) increased the firing rate from 0.76 +/- 0.3 Hz to 2.3 +/- 0.5 Hz (n = 6, P &lt; 0.05) and increased the neuronal subthreshold activity.	Tetradecanoylphorbol Acetate	70-101	angiotensinogen	Rattus norvegicus	25-31
9307112-13	1997	The activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) increases the amplitude of the Ca2+ current, diminishes facilitation, and reduces the inhibition of this current by UK14304 and VIP.	Tetradecanoylphorbol Acetate	79-82	vasoactive intestinal peptide	Rattus norvegicus	212-215
9307131-7	1997	Similar to the action of Ang II, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA, 100 nM) increased the firing rate from 0.76 +/- 0.3 Hz to 2.3 +/- 0.5 Hz (n = 6, P &lt; 0.05) and increased the neuronal subthreshold activity.	Tetradecanoylphorbol Acetate	103-106	angiotensinogen	Rattus norvegicus	25-31
9288124-11	1997	CONCLUSIONS: Direct PKC activation with PMA restored TNF secretion in LPS-tolerant macrophages.	Tetradecanoylphorbol Acetate	40-43	tumor necrosis factor	Mus musculus	53-56
9271352-9	1997	In Jurkat T cells activated by phorbol-12-myristate-13-acetate and phytohemagglutinin, CCK-8 induced IL-2 expression.	Tetradecanoylphorbol Acetate	31-62	interleukin 2	Homo sapiens	101-105
10453561-6	1997	The activity of NEP inactivated by PMA (without HIM82) is (43.29 +/- 9.41)% (n = 8, P &lt; 0.05) and the activity is (66.48 +/- 15.53)% (n = 8, P &lt; 0.05) in PMA-inactivated group with HIM82.	Tetradecanoylphorbol Acetate	35-38	membrane metalloendopeptidase	Homo sapiens	16-19
9218600-4	1997	CD50 mAbs were found to inhibit neutrophil adhesion induced by FMLP and 12-O-tetradecanoyl-phorbol-13-acetate to resting and TNF-activated HUVEC.	Tetradecanoylphorbol Acetate	72-109	tumor necrosis factor	Homo sapiens	125-128
9218566-2	1997	PMA alone induced the production of low levels of IL-1beta in THP-1 cells, whereas dexamethasone alone had no effect.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Homo sapiens	50-58
9230073-5	1997	The protein kinase C (PKC) activator phorbol-12 myristate-13 acetate (PMA) inhibited apical lipid transport via both transport routes, while a specific inhibitor of this kinase stimulated apical lipid transport.	Tetradecanoylphorbol Acetate	37-68	proline rich transmembrane protein 2	Homo sapiens	4-20
9230073-5	1997	The protein kinase C (PKC) activator phorbol-12 myristate-13 acetate (PMA) inhibited apical lipid transport via both transport routes, while a specific inhibitor of this kinase stimulated apical lipid transport.	Tetradecanoylphorbol Acetate	37-68	proline rich transmembrane protein 2	Homo sapiens	22-25
9230073-5	1997	The protein kinase C (PKC) activator phorbol-12 myristate-13 acetate (PMA) inhibited apical lipid transport via both transport routes, while a specific inhibitor of this kinase stimulated apical lipid transport.	Tetradecanoylphorbol Acetate	70-73	proline rich transmembrane protein 2	Homo sapiens	4-20
9230073-5	1997	The protein kinase C (PKC) activator phorbol-12 myristate-13 acetate (PMA) inhibited apical lipid transport via both transport routes, while a specific inhibitor of this kinase stimulated apical lipid transport.	Tetradecanoylphorbol Acetate	70-73	proline rich transmembrane protein 2	Homo sapiens	22-25
9230073-8	1997	Stimulation of PKC activity resulted in a disappearance of the bile canalicular structures, as evidenced by the redistribution of several apical markers upon PMA treatment, which was accompanied by an inhibition of apical sphingolipid transport.	Tetradecanoylphorbol Acetate	158-161	proline rich transmembrane protein 2	Homo sapiens	15-18
9218566-6	1997	Using an oligonucleotide probe corresponding to an NF-kappaB DNA-binding motif of the IL-1beta gene promoter in gel electrophoresis mobility shift assays, we demonstrated that PMA-induced NF-kappaB activation was greatly potentiated by dexamethasone.	Tetradecanoylphorbol Acetate	176-179	nuclear factor kappa B subunit 1	Homo sapiens	51-60
9218566-6	1997	Using an oligonucleotide probe corresponding to an NF-kappaB DNA-binding motif of the IL-1beta gene promoter in gel electrophoresis mobility shift assays, we demonstrated that PMA-induced NF-kappaB activation was greatly potentiated by dexamethasone.	Tetradecanoylphorbol Acetate	176-179	interleukin 1 beta	Homo sapiens	86-94
9272635-2	1997	The protein kinase C (PKC)-activating tumor promoters mezerein and phorbol 12-myristate 13-acetate (PMA), but not the inactive phorbol ester analog 4alpha-PMA, caused a pronounced decrease of myelin basic protein (MBP) content and 2",3"-cyclic nucleotide 3"-phosphohydrolase (CNP) activity.	Tetradecanoylphorbol Acetate	67-98	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	276-279
9218566-6	1997	Using an oligonucleotide probe corresponding to an NF-kappaB DNA-binding motif of the IL-1beta gene promoter in gel electrophoresis mobility shift assays, we demonstrated that PMA-induced NF-kappaB activation was greatly potentiated by dexamethasone.	Tetradecanoylphorbol Acetate	176-179	nuclear factor kappa B subunit 1	Homo sapiens	188-197
9272635-2	1997	The protein kinase C (PKC)-activating tumor promoters mezerein and phorbol 12-myristate 13-acetate (PMA), but not the inactive phorbol ester analog 4alpha-PMA, caused a pronounced decrease of myelin basic protein (MBP) content and 2",3"-cyclic nucleotide 3"-phosphohydrolase (CNP) activity.	Tetradecanoylphorbol Acetate	100-103	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	276-279
9201982-6	1997	Further, ligand blotting of glycoproteins isolated from phorbol 12-myristate 13-acetate-treated THP-1 cells or from transfected HepG2 and Chinese hamster ovary cells also provided evidence of increased binding of HDL3 to HB2.	Tetradecanoylphorbol Acetate	56-87	HDL3	Homo sapiens	213-217
9223377-1	1997	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is a potent mitogenic factor which can replace the growth promoting activity of basic fibroblast growth factor (bFGF) on bovine aortic endothelial cells.	Tetradecanoylphorbol Acetate	19-55	fibroblast growth factor 2	Bos taurus	142-172
9223377-1	1997	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is a potent mitogenic factor which can replace the growth promoting activity of basic fibroblast growth factor (bFGF) on bovine aortic endothelial cells.	Tetradecanoylphorbol Acetate	19-55	fibroblast growth factor 2	Bos taurus	174-178
9223377-1	1997	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is a potent mitogenic factor which can replace the growth promoting activity of basic fibroblast growth factor (bFGF) on bovine aortic endothelial cells.	Tetradecanoylphorbol Acetate	57-60	fibroblast growth factor 2	Bos taurus	142-172
9223377-1	1997	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is a potent mitogenic factor which can replace the growth promoting activity of basic fibroblast growth factor (bFGF) on bovine aortic endothelial cells.	Tetradecanoylphorbol Acetate	57-60	fibroblast growth factor 2	Bos taurus	174-178
9223377-2	1997	However, TPA-treated cells lose their strict contact inhibition at confluence, which is a characteristic of cells grown in the presence of bFGF.	Tetradecanoylphorbol Acetate	9-12	fibroblast growth factor 2	Bos taurus	139-143
9223377-4	1997	In TPA-treated cells, the three fluorescent phospholipids remained located in the outer leaflet for at least 1 h at 20 degrees C after their insertion, indicating a blockade of the aminophospholipid translocase activity which is normally present in the plasma membrane of bFGF-treated cells.	Tetradecanoylphorbol Acetate	3-6	fibroblast growth factor 2	Bos taurus	272-276
9202001-1	1997	Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.	Tetradecanoylphorbol Acetate	39-70	mitogen-activated protein kinase 1	Homo sapiens	103-142
9202001-1	1997	Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.	Tetradecanoylphorbol Acetate	39-70	mitogen-activated protein kinase 1	Homo sapiens	144-148
9202001-1	1997	Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.	Tetradecanoylphorbol Acetate	39-70	mitogen-activated protein kinase 9	Homo sapiens	151-182
9202001-1	1997	Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.	Tetradecanoylphorbol Acetate	39-70	mitogen-activated protein kinase 9	Homo sapiens	184-188
9202001-8	1997	Conditional expression of MKP-1 also abolished the induction of endogenous MKP-1 protein expression in response to PMA treatment.	Tetradecanoylphorbol Acetate	115-118	dual specificity phosphatase 1	Homo sapiens	26-31
9202001-8	1997	Conditional expression of MKP-1 also abolished the induction of endogenous MKP-1 protein expression in response to PMA treatment.	Tetradecanoylphorbol Acetate	115-118	dual specificity phosphatase 1	Homo sapiens	75-80
9202001-1	1997	Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.	Tetradecanoylphorbol Acetate	39-70	mitogen-activated protein kinase 1	Homo sapiens	195-198
9202001-1	1997	Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.	Tetradecanoylphorbol Acetate	39-70	mitogen-activated protein kinase 1	Homo sapiens	233-237
9202043-5	1997	In this study, we found that activation of human neutrophils with formyl-methionyl-leucyl-phenylalanine (fMLP), a chemotactic peptide, or phorbol myristate acetate (PMA), a stimulator of protein kinase C (PKC), resulted in the phosphorylation of p67(phox).	Tetradecanoylphorbol Acetate	165-168	proline rich transmembrane protein 2	Homo sapiens	187-203
9202001-1	1997	Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 1	Homo sapiens	103-142
9202001-1	1997	Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 1	Homo sapiens	144-148
9202001-1	1997	Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 9	Homo sapiens	151-182
9202001-1	1997	Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 9	Homo sapiens	184-188
9202001-1	1997	Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 1	Homo sapiens	195-198
9202001-1	1997	Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 1	Homo sapiens	233-237
9202001-5	1997	Conditional expression of MKP-1 inhibited PMA-induced ERK2, SAPK, and p38 MAPK activity.	Tetradecanoylphorbol Acetate	42-45	dual specificity phosphatase 1	Homo sapiens	26-31
9202001-5	1997	Conditional expression of MKP-1 inhibited PMA-induced ERK2, SAPK, and p38 MAPK activity.	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 1	Homo sapiens	54-58
9202001-5	1997	Conditional expression of MKP-1 inhibited PMA-induced ERK2, SAPK, and p38 MAPK activity.	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 9	Homo sapiens	60-64
9202001-5	1997	Conditional expression of MKP-1 inhibited PMA-induced ERK2, SAPK, and p38 MAPK activity.	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 1	Homo sapiens	70-73
9202043-5	1997	In this study, we found that activation of human neutrophils with formyl-methionyl-leucyl-phenylalanine (fMLP), a chemotactic peptide, or phorbol myristate acetate (PMA), a stimulator of protein kinase C (PKC), resulted in the phosphorylation of p67(phox).	Tetradecanoylphorbol Acetate	165-168	proline rich transmembrane protein 2	Homo sapiens	205-208
9202001-5	1997	Conditional expression of MKP-1 inhibited PMA-induced ERK2, SAPK, and p38 MAPK activity.	Tetradecanoylphorbol Acetate	42-45	mitogen-activated protein kinase 1	Homo sapiens	74-78
9230140-3	1997	A similar enhancement was seen with PMA, a stimulus that acts on protein kinase C (PKC), or calcium ionophore (A23187), which increases intracellular calcium, suggesting that the effect of the fatty acids was post-surface receptor binding.	Tetradecanoylphorbol Acetate	36-39	protein kinase C alpha	Homo sapiens	83-86
9202043-5	1997	In this study, we found that activation of human neutrophils with formyl-methionyl-leucyl-phenylalanine (fMLP), a chemotactic peptide, or phorbol myristate acetate (PMA), a stimulator of protein kinase C (PKC), resulted in the phosphorylation of p67(phox).	Tetradecanoylphorbol Acetate	165-168	CD33 molecule	Homo sapiens	246-249
9230140-9	1997	The synergistic response between fatty acids and A23187 was completely inhibited by pretreating the cells with a PKC inhibitor, GF-109203X, or by pretreatment of monocytes with PMA for 18 h, to deplete PKC levels.	Tetradecanoylphorbol Acetate	177-180	protein kinase C alpha	Homo sapiens	202-205
9202001-7	1997	This differential substrate specificity of MKP-1 can be functionally extended to nuclear transcriptional events in that PMA-induced c-Jun transcriptional activity was more sensitive to inhibition by MKP-1 than either Elk-1 or c-Myc.	Tetradecanoylphorbol Acetate	120-123	dual specificity phosphatase 1	Homo sapiens	43-48
9202001-7	1997	This differential substrate specificity of MKP-1 can be functionally extended to nuclear transcriptional events in that PMA-induced c-Jun transcriptional activity was more sensitive to inhibition by MKP-1 than either Elk-1 or c-Myc.	Tetradecanoylphorbol Acetate	120-123	dual specificity phosphatase 1	Homo sapiens	199-204
9202043-5	1997	In this study, we found that activation of human neutrophils with formyl-methionyl-leucyl-phenylalanine (fMLP), a chemotactic peptide, or phorbol myristate acetate (PMA), a stimulator of protein kinase C (PKC), resulted in the phosphorylation of p67(phox).	Tetradecanoylphorbol Acetate	165-168	CD33 molecule	Homo sapiens	250-254
9202043-10	1997	PMA-induced phosphorylation of p67(phox) was strongly inhibited by the PKC inhibitor GF109203X.	Tetradecanoylphorbol Acetate	0-3	CD33 molecule	Homo sapiens	31-40
9202043-10	1997	PMA-induced phosphorylation of p67(phox) was strongly inhibited by the PKC inhibitor GF109203X.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	71-74
9246383-5	1997	Following prolonged pre-treatment with tetradecanoyl phorbol acetate (100 nmol L-1), which down-regulates PKC-alpha and delta, the angiotensin-induced PKC translocation was lost.	Tetradecanoylphorbol Acetate	39-68	protein kinase C alpha	Homo sapiens	106-115
9246383-5	1997	Following prolonged pre-treatment with tetradecanoyl phorbol acetate (100 nmol L-1), which down-regulates PKC-alpha and delta, the angiotensin-induced PKC translocation was lost.	Tetradecanoylphorbol Acetate	39-68	protein kinase C alpha	Homo sapiens	106-109
9249599-4	1997	Inhibition of phospholipase C by treatment with 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate (NCDC), inhibition of protein kinase C (PKC) by staurosporine, or long-term (24 h) treatment with phorbol 12-myristate 13-acetate (PMA) to downregulate PKC abolished most of the osmo-induced, dihydropyridine-sensitive calcium influx signal.	Tetradecanoylphorbol Acetate	192-223	LOC100009319	Oryctolagus cuniculus	14-29
9249599-4	1997	Inhibition of phospholipase C by treatment with 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate (NCDC), inhibition of protein kinase C (PKC) by staurosporine, or long-term (24 h) treatment with phorbol 12-myristate 13-acetate (PMA) to downregulate PKC abolished most of the osmo-induced, dihydropyridine-sensitive calcium influx signal.	Tetradecanoylphorbol Acetate	225-228	LOC100009319	Oryctolagus cuniculus	14-29
9237814-6	1997	Activation of PKC by phorbol myristate acetate was also an effective stimulus to IL-8 production and this was blocked by PKC depletion or inhibitors.	Tetradecanoylphorbol Acetate	21-46	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
9282789-1	1997	Fibrinogen is a complex multifunctional protein comprised of three major domains (two outer D and one central E) which contains constitutive binding sites (e.g. Da, Db, gammaXL, D:D, gamma", thrombin substrate, platelet receptor) as well as binding sites that become exposed or expressed as a result of fibrinogen proteolysis by thrombin and/or that are exposed as a consequence of the polymerization process itself (tPA binding sites).	Tetradecanoylphorbol Acetate	417-420	fibrinogen beta chain	Homo sapiens	0-10
9282789-2	1997	Fibrin-dependent tPA-mediated activation of plasminogen is associated with exposure of polymerization-dependent epitopes (Aalpha148-160, gamma312-324) that are expressed in assembled fibrin and in crosslinked (polymerized) fibrinogen but not in unpolymerized fibrinogen or fibrin.	Tetradecanoylphorbol Acetate	17-20	fibrinogen beta chain	Homo sapiens	223-233
9282789-2	1997	Fibrin-dependent tPA-mediated activation of plasminogen is associated with exposure of polymerization-dependent epitopes (Aalpha148-160, gamma312-324) that are expressed in assembled fibrin and in crosslinked (polymerized) fibrinogen but not in unpolymerized fibrinogen or fibrin.	Tetradecanoylphorbol Acetate	17-20	fibrinogen beta chain	Homo sapiens	259-269
9215309-6	1997	In response to either 12-0-tetradecanoylphorbol-13-acetate (TPA) or 8-bromo-cAMP, we observed an increase in PGHS-2 promoter activity but no change in activity of PGHS-1 promoter.	Tetradecanoylphorbol Acetate	60-63	prostaglandin-endoperoxide synthase 2	Homo sapiens	109-115
9246192-6	1997	At the transcriptional level, a slight increase of IL-6 transcripts was already detectable 1 h after irradiation, with maximum levels at 2 h, and a decline to baseline levels between 8 and 24 h. Addition of the transcriptional inhibitor actinomycin D inhibited the inducibility of IL-6 mRNA by TPA and IR.	Tetradecanoylphorbol Acetate	294-297	interleukin 6	Homo sapiens	51-55
9246192-8	1997	All corticosteroids applied could efficiently downregulate TPA- or radiation-induced IL-6 expression on both gene expression and protein levels.	Tetradecanoylphorbol Acetate	59-62	interleukin 6	Homo sapiens	85-89
9215309-9	1997	Aspirin attenuated the stimulatory effect of TPA on PGHS-2 promoter.	Tetradecanoylphorbol Acetate	45-48	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-58
9215309-11	1997	The activity of PGHS-2 promoter is stimulated by either TPA or cAMP, and the stimulatory effect of TPA is attenuated by aspirin.	Tetradecanoylphorbol Acetate	56-59	prostaglandin-endoperoxide synthase 2	Homo sapiens	16-22
9215309-11	1997	The activity of PGHS-2 promoter is stimulated by either TPA or cAMP, and the stimulatory effect of TPA is attenuated by aspirin.	Tetradecanoylphorbol Acetate	99-102	prostaglandin-endoperoxide synthase 2	Homo sapiens	16-22
9204988-6	1997	Activation of the cells with phorbol-12 myristate 13-acetate (PMA) up-regulates the expression of the CD69 activation antigen and down-regulates the CD117 molecule.	Tetradecanoylphorbol Acetate	29-60	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	149-154
9211989-9	1997	Cells exposed to TPA showed an enhanced immunoreaction for Int alpha2 and beta1 subunits, suggestive of Int alpha2beta1, and for Int alpha(v) subunit.	Tetradecanoylphorbol Acetate	17-20	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	74-79
9204988-6	1997	Activation of the cells with phorbol-12 myristate 13-acetate (PMA) up-regulates the expression of the CD69 activation antigen and down-regulates the CD117 molecule.	Tetradecanoylphorbol Acetate	62-65	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	149-154
9254882-7	1997	A role for protein kinase C (PKC) was suggested for both TPA and 12(S)-HETE based on the loss of response with the PKC inhibitors bryostatin-1 or RO-31-8220.	Tetradecanoylphorbol Acetate	57-60	protein kinase C, alpha	Mus musculus	29-32
9199340-4	1997	The RE/AP composite element is a site for signal integration within the IL-2 promoter, since its activation is dependent on at least two separate signalling pathways being activated, through the T-cell receptor, CD28, and/or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	225-250	interleukin 2	Homo sapiens	72-76
9254882-8	1997	Both TPA and 12(S)-HETE stimulated keratinocyte PKC activity.	Tetradecanoylphorbol Acetate	5-8	protein kinase C, alpha	Mus musculus	48-51
9254887-4	1997	Cotransfection of K14TAM67 with luciferase plasmid reporter DNAs produced inhibition of basal and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 and NF kappa B activity but had no effect on p53-dependent transcriptional activity.	Tetradecanoylphorbol Acetate	98-134	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-168
9254887-4	1997	Cotransfection of K14TAM67 with luciferase plasmid reporter DNAs produced inhibition of basal and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 and NF kappa B activity but had no effect on p53-dependent transcriptional activity.	Tetradecanoylphorbol Acetate	136-139	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-168
9254882-10	1997	Immunoblotting showed that whereas TPA caused a rapid, partial translocation of the PKC alpha isozyme, it had no effect on the distribution of PKC delta.	Tetradecanoylphorbol Acetate	35-38	protein kinase C, alpha	Mus musculus	84-93
9254887-6	1997	This suggests that blocking TPA-induced AP-1- or NF kappa B-regulated gene expression by TAM67 inhibits TPA-induced progression.	Tetradecanoylphorbol Acetate	28-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-59
9443579-3	1997	Stimulation by phorbol myristate acetate (PMA) (100 ng/ml for 48 h) induced TNF alpha secretion in THP-1 and Namalwa cells (100 to 300 pg/ml).	Tetradecanoylphorbol Acetate	15-40	tumor necrosis factor	Homo sapiens	76-85
9254887-6	1997	This suggests that blocking TPA-induced AP-1- or NF kappa B-regulated gene expression by TAM67 inhibits TPA-induced progression.	Tetradecanoylphorbol Acetate	104-107	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-59
9254887-7	1997	Recombinant tissue inhibitor of metalloproteinase 1 reduced TPA-induced in vitro invasion, thus implicating metalloproteinases at least in part in the transcription factor-dependent process.	Tetradecanoylphorbol Acetate	60-63	tissue inhibitor of metalloproteinase 1	Mus musculus	12-51
9254887-10	1997	These results suggest that the action of the dominant negative jun mutant on AP-1 and NF kappa B gene regulation results in complex alterations in the levels of downstream effector genes, such as the metalloproteinases, that effect TPA-induced cellular invasion.	Tetradecanoylphorbol Acetate	232-235	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-96
9232628-2	1997	HuIFN alpha-2b and TPA increased PKC activity, elevated the number of cells in DNA synthesis (S) phase and decreased cell proliferation by similar magnitudes.	Tetradecanoylphorbol Acetate	19-22	proline rich transmembrane protein 2	Homo sapiens	33-36
9232628-6	1997	The response produced by HuIFN alpha-2b is similar to TPA (potent PKC activation and S phase arrest).	Tetradecanoylphorbol Acetate	54-57	proline rich transmembrane protein 2	Homo sapiens	66-69
9443579-3	1997	Stimulation by phorbol myristate acetate (PMA) (100 ng/ml for 48 h) induced TNF alpha secretion in THP-1 and Namalwa cells (100 to 300 pg/ml).	Tetradecanoylphorbol Acetate	15-40	GLI family zinc finger 2	Homo sapiens	99-104
9443579-3	1997	Stimulation by phorbol myristate acetate (PMA) (100 ng/ml for 48 h) induced TNF alpha secretion in THP-1 and Namalwa cells (100 to 300 pg/ml).	Tetradecanoylphorbol Acetate	42-45	tumor necrosis factor	Homo sapiens	76-85
9443579-3	1997	Stimulation by phorbol myristate acetate (PMA) (100 ng/ml for 48 h) induced TNF alpha secretion in THP-1 and Namalwa cells (100 to 300 pg/ml).	Tetradecanoylphorbol Acetate	42-45	GLI family zinc finger 2	Homo sapiens	99-104
9177197-4	1997	Furthermore, GITR expression was induced in T lymphocytes upon activation by anti-CD3 mAb, Con A, or phorbol 12-myristate 13-acetate plus Ca-ionophore treatment.	Tetradecanoylphorbol Acetate	101-132	tumor necrosis factor receptor superfamily, member 18	Mus musculus	13-17
9207176-2	1997	The reduction of perforin-dependent LAK activity by PMA-treatment appeared to be due to the disappearance of PMA-sensitive protein kinase C (PKC) isoforms such as PKC alpha, gamma, epsilon, theta.	Tetradecanoylphorbol Acetate	52-55	protein kinase C, alpha	Mus musculus	141-144
9207176-2	1997	The reduction of perforin-dependent LAK activity by PMA-treatment appeared to be due to the disappearance of PMA-sensitive protein kinase C (PKC) isoforms such as PKC alpha, gamma, epsilon, theta.	Tetradecanoylphorbol Acetate	52-55	protein kinase C, alpha	Mus musculus	163-195
9207176-6	1997	These results clearly demonstrated that Fas-mediated cytotoxicity could be dissociated from perforin-mediated cytotoxicity by their different requirement of PMA-sensitive PKC isoforms.	Tetradecanoylphorbol Acetate	157-160	protein kinase C, alpha	Mus musculus	171-174
9192835-6	1997	Phorbol 12-myristate 13-acetate and 12(S)-hydroxyeicosatetraenoic acid, two activators of protein kinase C, stimulated adhesion of melanoma cells to immobilized fibronectin and PAC-1, a mAb to alphaIIb beta3.	Tetradecanoylphorbol Acetate	0-31	fibronectin 1	Homo sapiens	161-172
9210518-2	1997	In the AM, the formation of a specific protein complex with the TPA-responsive element located in the proximal region of the TH gene was enhanced between 30 min and 8 hr following the injection.	Tetradecanoylphorbol Acetate	64-67	tyrosine hydroxylase	Homo sapiens	125-127
9200866-4	1997	Here we show that both receptor-mediated (vasopressin) and unspecific stimulation of the Ca2+ signaling system by the lipophilic tumor promoters thapsigargin (TG) and phorbolmyristateacetate (PMA) are accompanied by the same type of morphological changes of the cell surface.	Tetradecanoylphorbol Acetate	167-190	arginine vasopressin	Rattus norvegicus	42-53
9227325-6	1997	Stimulation of synovial cells with interferon-gamma (IFN-gamma), IL-1 beta, or 12-O-tetradecanoyl phorbol 13-acetate (TPA) markedly enhanced the expression of costimulatory molecules and cytokine production of these cells.	Tetradecanoylphorbol Acetate	118-121	interferon gamma	Homo sapiens	35-51
9189762-12	1997	Second, interleukin-2 production after TCR/CD3 engagement and TCR/CD3 down-modulation in response to phorbol myristate acetate were shown to be comparable to wild-type Jurkat cells.	Tetradecanoylphorbol Acetate	101-126	interleukin 2	Homo sapiens	8-21
9190898-1	1997	While the standard form of CD44 was expressed at high levels in both treated and untreated cells, variant isoforms were strongly upregulated in response to treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA), insulin-like growth factor-1 (IGF-1) and platelet-derived growth factor (PDGF) as shown by RT-PCR and immunofluorescence.	Tetradecanoylphorbol Acetate	210-213	insulin like growth factor 1	Homo sapiens	216-244
9190898-1	1997	While the standard form of CD44 was expressed at high levels in both treated and untreated cells, variant isoforms were strongly upregulated in response to treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA), insulin-like growth factor-1 (IGF-1) and platelet-derived growth factor (PDGF) as shown by RT-PCR and immunofluorescence.	Tetradecanoylphorbol Acetate	210-213	insulin like growth factor 1	Homo sapiens	246-251
9169474-4	1997	12-O-Tetradecanoylphorbol 13-acetate (TPA), which slowly activated CADTK, did not stimulate JNK.	Tetradecanoylphorbol Acetate	0-36	protein tyrosine kinase 2 beta	Rattus norvegicus	67-72
9169474-4	1997	12-O-Tetradecanoylphorbol 13-acetate (TPA), which slowly activated CADTK, did not stimulate JNK.	Tetradecanoylphorbol Acetate	38-41	protein tyrosine kinase 2 beta	Rattus norvegicus	67-72
9169474-6	1997	A 1-min TPA pretreatment of GN4 cells inhibited thapsigargin-dependent JNK activation by 80-90%.	Tetradecanoylphorbol Acetate	8-11	mitogen-activated protein kinase 8	Homo sapiens	71-74
9164825-4	1997	CT alone did not influence the expression of c-jun and of the tissue inhibitors of metalloproteases (timp) -1 and -2 mRNAs; however, it reduced the induction of these mRNAs by the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA), without apparent changes in the half-life of the mRNA (measured for c-jun).	Tetradecanoylphorbol Acetate	213-244	calcitonin related polypeptide alpha	Homo sapiens	0-2
9241533-1	1997	Leukosialin (CD43), the major sialoprotein on circulating leukocytes, has been previously described to be down-regulated on neutrophils following activation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	162-187	sialophorin	Homo sapiens	13-17
9166410-7	1997	Classical and confocal immunofluorescence showed only minor TPA-induced changes in E-cadherin staining.	Tetradecanoylphorbol Acetate	60-63	cadherin 1	Homo sapiens	83-93
9166410-10	1997	TPA-restored cell-cell adhesion was E-cadherin dependent as demonstrated by a blocking antibody in a cell aggregation assay.	Tetradecanoylphorbol Acetate	0-3	cadherin 1	Homo sapiens	36-46
9166410-12	1997	Remarkably, the combination of anti-E-cadherin and anti-desmoglein antibodies synergistically inhibited the TPA effect.	Tetradecanoylphorbol Acetate	108-111	cadherin 1	Homo sapiens	36-46
9214631-7	1997	Moreover, when the function of p90rsk1 is impaired by expression of a dominant-negative mutant, IkappaB alpha degradation in response to mitogenic stimuli, e.g. 12-O-tetradecanoylphorbol 13-acetate (TPA), is inhibited.	Tetradecanoylphorbol Acetate	161-197	NFKB inhibitor alpha	Homo sapiens	96-109
9214631-7	1997	Moreover, when the function of p90rsk1 is impaired by expression of a dominant-negative mutant, IkappaB alpha degradation in response to mitogenic stimuli, e.g. 12-O-tetradecanoylphorbol 13-acetate (TPA), is inhibited.	Tetradecanoylphorbol Acetate	199-202	NFKB inhibitor alpha	Homo sapiens	96-109
9191470-7	1997	The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway.	Tetradecanoylphorbol Acetate	240-265	interleukin 1 beta	Homo sapiens	4-13
9191470-7	1997	The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway.	Tetradecanoylphorbol Acetate	267-270	interleukin 1 beta	Homo sapiens	4-13
9241533-1	1997	Leukosialin (CD43), the major sialoprotein on circulating leukocytes, has been previously described to be down-regulated on neutrophils following activation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	189-192	sialophorin	Homo sapiens	13-17
9241533-7	1997	Inhibitors of serine proteases, like phenylmethylsulphonyl fluoride (PMSF), benzamidine and 3, 4-dichloroisocoumarin, blocked the PMA-mediated cleavage of CD43.	Tetradecanoylphorbol Acetate	130-133	sialophorin	Homo sapiens	155-159
9169347-10	1997	Similarly, 17 beta-E2 inhibited PMA-stimulated IL-6 production, whereas neither forskolin-stimulated IL-6/ IL-11 production nor PMA-stimulated IL-11 production was affected by 17 beta-E2.	Tetradecanoylphorbol Acetate	32-35	interleukin 6	Homo sapiens	47-51
9169347-5	1997	Agonists for protein kinase A (PKA) (forskolin), and protein kinase C (PKC) (phorbol 12-myristate 13-acetate; PMA) also stimulated IL-6/IL-11 production.	Tetradecanoylphorbol Acetate	77-108	interleukin 6	Homo sapiens	131-135
9201257-6	1997	Cultured EBV-B lymphocytes and a human plasma cell line (ARH-77) when stimulated with phorbol myristate acetate demonstrated cytoplasmic TNF-alpha immunoreactivity.	Tetradecanoylphorbol Acetate	86-111	tumor necrosis factor	Homo sapiens	137-146
9201260-5	1997	SLPI can be secreted (probably in an inactive form) by neutrophils and its secretion is enhanced when the cells are stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	132-157	secretory leukocyte peptidase inhibitor	Homo sapiens	0-4
9201260-5	1997	SLPI can be secreted (probably in an inactive form) by neutrophils and its secretion is enhanced when the cells are stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	159-162	secretory leukocyte peptidase inhibitor	Homo sapiens	0-4
9241751-1	1997	Previous investigations suggested that heparin administration to humans enhances the tissue type plasminogen activator (tPA) levels in blood, but it remains uncertain whether this effect induces fibrinolysis.	Tetradecanoylphorbol Acetate	120-123	plasminogen activator, tissue type	Homo sapiens	85-118
9209506-7	1997	In contrast, PMA-induced C5aR internalization seems to be independent of putative phosphorylation sites in either the truncated section of the C terminus or the third cytosolic loop.	Tetradecanoylphorbol Acetate	13-16	complement C5a receptor 1	Homo sapiens	25-29
11039029-0	1997	[Changes of PKC isoforms in induced differentiation of HL-60 cells by ATRA and PMA].	Tetradecanoylphorbol Acetate	79-82	proline rich transmembrane protein 2	Homo sapiens	12-15
9169013-4	1997	The addition of 1,2-dioctanoyl-sn-glycerol (DOG) or 12-O-tetradecanoylphorbol 13-acetate (TPA), a PKC activator that mimics diacylglycerol function, to cultures led to a significant decrease of both basal and phenobarbital-induced ALA-S mRNA levels in a dose-dependent manner.	Tetradecanoylphorbol Acetate	52-88	5'-aminolevulinate synthase 1	Rattus norvegicus	231-236
9184073-6	1997	Kinetic studies indicated that fibronectin was rapidly secreted as an intact molecule and that proteolysis started within minutes and proceeded for at least 1 h. If cells were removed after 5 min TPA treatment, no further proteolysis of the secreted fibronectin was observed, indicating participation of cell-bound proteinases.	Tetradecanoylphorbol Acetate	196-199	fibronectin 1	Homo sapiens	31-42
9148913-9	1997	Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC that interacts with the C1 region of PKC, inhibited the PKC-PH domain interaction, whereas the bioinactive PMA (4-alpha-PMA) was ineffective.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	61-64
9148913-9	1997	Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC that interacts with the C1 region of PKC, inhibited the PKC-PH domain interaction, whereas the bioinactive PMA (4-alpha-PMA) was ineffective.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	102-105
9148913-9	1997	Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC that interacts with the C1 region of PKC, inhibited the PKC-PH domain interaction, whereas the bioinactive PMA (4-alpha-PMA) was ineffective.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	102-105
9148913-9	1997	Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC that interacts with the C1 region of PKC, inhibited the PKC-PH domain interaction, whereas the bioinactive PMA (4-alpha-PMA) was ineffective.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	61-64
9148913-9	1997	Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC that interacts with the C1 region of PKC, inhibited the PKC-PH domain interaction, whereas the bioinactive PMA (4-alpha-PMA) was ineffective.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	102-105
9148913-9	1997	Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC that interacts with the C1 region of PKC, inhibited the PKC-PH domain interaction, whereas the bioinactive PMA (4-alpha-PMA) was ineffective.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	102-105
9148913-9	1997	Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC that interacts with the C1 region of PKC, inhibited the PKC-PH domain interaction, whereas the bioinactive PMA (4-alpha-PMA) was ineffective.	Tetradecanoylphorbol Acetate	172-175	proline rich transmembrane protein 2	Homo sapiens	61-64
9148913-9	1997	Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC that interacts with the C1 region of PKC, inhibited the PKC-PH domain interaction, whereas the bioinactive PMA (4-alpha-PMA) was ineffective.	Tetradecanoylphorbol Acetate	172-175	proline rich transmembrane protein 2	Homo sapiens	102-105
9148913-9	1997	Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC that interacts with the C1 region of PKC, inhibited the PKC-PH domain interaction, whereas the bioinactive PMA (4-alpha-PMA) was ineffective.	Tetradecanoylphorbol Acetate	172-175	proline rich transmembrane protein 2	Homo sapiens	102-105
9177287-2	1997	An NFkappaB-luciferase reporter gene was activated by phorbol myristyl acetate (PMA) in both cell types.	Tetradecanoylphorbol Acetate	80-83	nuclear factor kappa B subunit 1	Homo sapiens	3-11
9144513-0	1997	Adenosine metabolism during phorbol myristate acetate-mediated induction of HL-60 cell differentiation: changes in expression pattern of adenosine kinase, adenosine deaminase, and 5"-nucleotidase.	Tetradecanoylphorbol Acetate	28-53	adenosine kinase	Homo sapiens	137-153
9184233-9	1997	Moreover, ROX expression appears to be induced in U937 myeloid leukemia cells stimulated to differentiate with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	111-147	MAX network transcriptional repressor	Homo sapiens	10-13
9164852-4	1997	Treatment of cells with 500 nM PMA for 3 h led to the complete depletion of PKC-delta and the partial depletion of PKC-alpha but did not significantly affect the expression of the other PKC isoforms.	Tetradecanoylphorbol Acetate	31-34	protein kinase C, alpha	Mus musculus	115-124
9164852-4	1997	Treatment of cells with 500 nM PMA for 3 h led to the complete depletion of PKC-delta and the partial depletion of PKC-alpha but did not significantly affect the expression of the other PKC isoforms.	Tetradecanoylphorbol Acetate	31-34	protein kinase C, alpha	Mus musculus	76-79
9176220-3	1997	The PKC inhibitors chelerythrine and Go-6976 reduced, whereas a PKC agonist, phorbol 12-myristate 13-acetate (PMA), increased glycochenodeoxycholate (GCDC)-induced hepatocyte apoptosis.	Tetradecanoylphorbol Acetate	77-108	protein kinase C alpha	Homo sapiens	64-67
9115222-5	1997	A protein kinase C (PKC) inhibitor blocked phosphorylation of PLCbeta3 stimulated by PAF and PMA but not by cAMP.	Tetradecanoylphorbol Acetate	93-96	proline rich transmembrane protein 2	Homo sapiens	2-18
9115222-5	1997	A protein kinase C (PKC) inhibitor blocked phosphorylation of PLCbeta3 stimulated by PAF and PMA but not by cAMP.	Tetradecanoylphorbol Acetate	93-96	proline rich transmembrane protein 2	Homo sapiens	20-23
9194577-13	1997	In mouse Swiss 3T3 cells TPA significantly increased cAMP stimulated by Bn, GRP or VIP.	Tetradecanoylphorbol Acetate	25-28	gastrin releasing peptide	Mus musculus	76-79
9194577-13	1997	In mouse Swiss 3T3 cells TPA significantly increased cAMP stimulated by Bn, GRP or VIP.	Tetradecanoylphorbol Acetate	25-28	vasoactive intestinal polypeptide	Mus musculus	83-86
9176246-9	1997	The GR antagonist RU-486 inhibited the repressive effect of Dex on TNF-alpha-induced NF-kappa B activity by 81% but only counteracted the repressive effect of Dex on TPA-induced AP-1 activity by 43%.	Tetradecanoylphorbol Acetate	166-169	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-182
9176220-3	1997	The PKC inhibitors chelerythrine and Go-6976 reduced, whereas a PKC agonist, phorbol 12-myristate 13-acetate (PMA), increased glycochenodeoxycholate (GCDC)-induced hepatocyte apoptosis.	Tetradecanoylphorbol Acetate	110-113	protein kinase C alpha	Homo sapiens	4-7
9157959-7	1997	Both aFGF and bFGF suppressed the phorbol myristate acetate-induced expression of TF in endothelial cells but not the serum-induced expression of TF in fibroblast cells.	Tetradecanoylphorbol Acetate	34-59	fibroblast growth factor 1	Homo sapiens	5-9
9143362-2	1997	Treatment of permeabilized cells with phorbol myristate acetate (PMA) strongly potentiated GTP gamma S-dependent PLD activity at free Ca2+ &lt; 100 nM.	Tetradecanoylphorbol Acetate	38-63	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	113-116
9143362-2	1997	Treatment of permeabilized cells with phorbol myristate acetate (PMA) strongly potentiated GTP gamma S-dependent PLD activity at free Ca2+ &lt; 100 nM.	Tetradecanoylphorbol Acetate	65-68	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	113-116
9143362-3	1997	In the absence of GTP gamma S, PMA stimulated only minor PLD activity.	Tetradecanoylphorbol Acetate	31-34	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	57-60
9157959-7	1997	Both aFGF and bFGF suppressed the phorbol myristate acetate-induced expression of TF in endothelial cells but not the serum-induced expression of TF in fibroblast cells.	Tetradecanoylphorbol Acetate	34-59	fibroblast growth factor 2	Homo sapiens	14-18
9144337-6	1997	Moreover, high Ca2+(o)-stimulated PLD activity was abolished following down-regulation of PKC by overnight phorbol myristate acetate (PMA) pretreatment, suggesting that CaR-mediated activation of PLD depends largely upon stimulation of PKC.	Tetradecanoylphorbol Acetate	134-137	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	34-37
9174164-1	1997	RGS1 and RGS2 are members of a new class of regulators of G-protein signaling identified by their selective mRNA expression either in phorbol ester (TPA)-stimulated human B lymphocytes (RGS1/1R20/BL34) or in blood mononuclear cells treated with the T-cell lectin concanavalin A (ConA) and cycloheximide (RGS2/G0S8).	Tetradecanoylphorbol Acetate	149-152	regulator of G protein signaling 1	Homo sapiens	0-4
9174164-1	1997	RGS1 and RGS2 are members of a new class of regulators of G-protein signaling identified by their selective mRNA expression either in phorbol ester (TPA)-stimulated human B lymphocytes (RGS1/1R20/BL34) or in blood mononuclear cells treated with the T-cell lectin concanavalin A (ConA) and cycloheximide (RGS2/G0S8).	Tetradecanoylphorbol Acetate	149-152	regulator of G protein signaling 1	Homo sapiens	186-195
9174164-5	1997	RGS1 mRNA levels increase much more in response to a protein kinase C activator (TPA), than to a calcium ionophore (ionomycin), whereas the opposite is true for RGS2.	Tetradecanoylphorbol Acetate	81-84	regulator of G protein signaling 1	Homo sapiens	0-4
9168824-5	1997	Activation of PKC by exposure of resident PM phi to phorbol myristate acetate (PMA) also resulted in enhanced IL-6 release and PMA was shown to synergize with CSF-1.	Tetradecanoylphorbol Acetate	52-77	interleukin 6	Mus musculus	110-114
9168824-5	1997	Activation of PKC by exposure of resident PM phi to phorbol myristate acetate (PMA) also resulted in enhanced IL-6 release and PMA was shown to synergize with CSF-1.	Tetradecanoylphorbol Acetate	79-82	interleukin 6	Mus musculus	110-114
9144337-5	1997	Brief treatment of parathyroid and HEK-CaR cells with an activator of protein kinase C (PKC), phorbol 12-myristate,13-acetate (PMA), stimulated PLD activity at both low and high Ca2+(o).	Tetradecanoylphorbol Acetate	127-130	calcium sensing receptor	Homo sapiens	39-42
9154324-16	1997	Treatment of the cells with PMA induced a time-dependent increase in the expression of both COX-1 and COX-2 mRNAs.	Tetradecanoylphorbol Acetate	28-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
9154324-21	1997	Overall, it appears that the stimulation of the HUV-EC-C line with PMA selectively induces the COX-2 isoenzyme.	Tetradecanoylphorbol Acetate	67-70	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	95-100
9158101-4	1997	Upon stimulation of KU812 cells with either phorbol myristate acetate (PMA) or ionomycin (Iono), IL-4, but not IL-13, was produced in response to Iono, while IL-13, but not IL-4, was inducible by PMA.	Tetradecanoylphorbol Acetate	44-69	interleukin 4	Homo sapiens	97-101
9158101-4	1997	Upon stimulation of KU812 cells with either phorbol myristate acetate (PMA) or ionomycin (Iono), IL-4, but not IL-13, was produced in response to Iono, while IL-13, but not IL-4, was inducible by PMA.	Tetradecanoylphorbol Acetate	44-69	interleukin 13	Homo sapiens	158-163
9158101-4	1997	Upon stimulation of KU812 cells with either phorbol myristate acetate (PMA) or ionomycin (Iono), IL-4, but not IL-13, was produced in response to Iono, while IL-13, but not IL-4, was inducible by PMA.	Tetradecanoylphorbol Acetate	71-74	interleukin 4	Homo sapiens	97-101
9158101-4	1997	Upon stimulation of KU812 cells with either phorbol myristate acetate (PMA) or ionomycin (Iono), IL-4, but not IL-13, was produced in response to Iono, while IL-13, but not IL-4, was inducible by PMA.	Tetradecanoylphorbol Acetate	71-74	interleukin 13	Homo sapiens	158-163
9158101-4	1997	Upon stimulation of KU812 cells with either phorbol myristate acetate (PMA) or ionomycin (Iono), IL-4, but not IL-13, was produced in response to Iono, while IL-13, but not IL-4, was inducible by PMA.	Tetradecanoylphorbol Acetate	196-199	interleukin 4	Homo sapiens	97-101
9183012-5	1997	Similarly, the expression of MEK- and of [Asn17]Ras mutants decreased the 12-O-tetradecanoyl-phorbol 13-acetate (TPA)-mediated p21(waf1/cip1) induction.	Tetradecanoylphorbol Acetate	74-111	mitogen-activated protein kinase kinase 7	Homo sapiens	29-32
9183012-5	1997	Similarly, the expression of MEK- and of [Asn17]Ras mutants decreased the 12-O-tetradecanoyl-phorbol 13-acetate (TPA)-mediated p21(waf1/cip1) induction.	Tetradecanoylphorbol Acetate	74-111	cyclin dependent kinase inhibitor 1A	Homo sapiens	127-140
9183012-5	1997	Similarly, the expression of MEK- and of [Asn17]Ras mutants decreased the 12-O-tetradecanoyl-phorbol 13-acetate (TPA)-mediated p21(waf1/cip1) induction.	Tetradecanoylphorbol Acetate	113-116	mitogen-activated protein kinase kinase 7	Homo sapiens	29-32
9183012-5	1997	Similarly, the expression of MEK- and of [Asn17]Ras mutants decreased the 12-O-tetradecanoyl-phorbol 13-acetate (TPA)-mediated p21(waf1/cip1) induction.	Tetradecanoylphorbol Acetate	113-116	cyclin dependent kinase inhibitor 1A	Homo sapiens	127-140
9183012-6	1997	Furthermore, TPA-induced and serum-induced p21(waf1/cip1) mRNA accumulation was blocked by pretreating the cells with the antioxidant compound N-acetylcysteine, suggesting that oxidative stress is involved in these responses.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	43-56
9183012-7	1997	p21(waf1/cip1) mRNA levels reached a maximum within 2 h of adding Et2Mal or TPA; however, the rate of transcription from a p21(waf1/cip1)-promoter construct did not increase during this period.	Tetradecanoylphorbol Acetate	76-79	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-13
9183012-7	1997	p21(waf1/cip1) mRNA levels reached a maximum within 2 h of adding Et2Mal or TPA; however, the rate of transcription from a p21(waf1/cip1)-promoter construct did not increase during this period.	Tetradecanoylphorbol Acetate	76-79	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-3
9183012-7	1997	p21(waf1/cip1) mRNA levels reached a maximum within 2 h of adding Et2Mal or TPA; however, the rate of transcription from a p21(waf1/cip1)-promoter construct did not increase during this period.	Tetradecanoylphorbol Acetate	76-79	cyclin dependent kinase inhibitor 1A	Homo sapiens	4-8
9183012-7	1997	p21(waf1/cip1) mRNA levels reached a maximum within 2 h of adding Et2Mal or TPA; however, the rate of transcription from a p21(waf1/cip1)-promoter construct did not increase during this period.	Tetradecanoylphorbol Acetate	76-79	cyclin dependent kinase inhibitor 1A	Homo sapiens	9-13
9183012-10	1997	Longer exposure to TPA may activate p21(waf1/cip1) gene transcription through an Sp1-dependent mechanism, while Et2Mal treatment gradually inhibits p21(waf1/cip1) gene transcription through oxidative changes that affect Sp1 binding to DNA.	Tetradecanoylphorbol Acetate	19-22	cyclin dependent kinase inhibitor 1A	Homo sapiens	36-39
9183012-10	1997	Longer exposure to TPA may activate p21(waf1/cip1) gene transcription through an Sp1-dependent mechanism, while Et2Mal treatment gradually inhibits p21(waf1/cip1) gene transcription through oxidative changes that affect Sp1 binding to DNA.	Tetradecanoylphorbol Acetate	19-22	cyclin dependent kinase inhibitor 1A	Homo sapiens	40-49
9183012-10	1997	Longer exposure to TPA may activate p21(waf1/cip1) gene transcription through an Sp1-dependent mechanism, while Et2Mal treatment gradually inhibits p21(waf1/cip1) gene transcription through oxidative changes that affect Sp1 binding to DNA.	Tetradecanoylphorbol Acetate	19-22	cyclin dependent kinase inhibitor 1A	Homo sapiens	36-49
21533484-4	1997	In MCF-7, pS2-triggered reporter gene expression is greatly enhanced by the tumor promoter TPA, and, to some extend by EGF, demonstrating that pS2 gene expression is due to specific trans-activating factors present in MCF-7, but not in PANG-I or CX-1.	Tetradecanoylphorbol Acetate	91-94	trefoil factor 1	Homo sapiens	10-13
9175709-4	1997	Both the human myeloid cell line HL-60, when differentiated by treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or retinoic acid, and human blood leukocytes, adhered to myeloperoxidase; however, undifferentiated HL-60 cells showed only minimal adhesion.	Tetradecanoylphorbol Acetate	117-120	myeloperoxidase	Homo sapiens	179-194
9144337-5	1997	Brief treatment of parathyroid and HEK-CaR cells with an activator of protein kinase C (PKC), phorbol 12-myristate,13-acetate (PMA), stimulated PLD activity at both low and high Ca2+(o).	Tetradecanoylphorbol Acetate	127-130	proline rich transmembrane protein 2	Homo sapiens	70-86
9144337-5	1997	Brief treatment of parathyroid and HEK-CaR cells with an activator of protein kinase C (PKC), phorbol 12-myristate,13-acetate (PMA), stimulated PLD activity at both low and high Ca2+(o).	Tetradecanoylphorbol Acetate	127-130	proline rich transmembrane protein 2	Homo sapiens	88-91
9144337-5	1997	Brief treatment of parathyroid and HEK-CaR cells with an activator of protein kinase C (PKC), phorbol 12-myristate,13-acetate (PMA), stimulated PLD activity at both low and high Ca2+(o).	Tetradecanoylphorbol Acetate	127-130	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	144-147
9144337-6	1997	Moreover, high Ca2+(o)-stimulated PLD activity was abolished following down-regulation of PKC by overnight phorbol myristate acetate (PMA) pretreatment, suggesting that CaR-mediated activation of PLD depends largely upon stimulation of PKC.	Tetradecanoylphorbol Acetate	107-132	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	34-37
9144337-6	1997	Moreover, high Ca2+(o)-stimulated PLD activity was abolished following down-regulation of PKC by overnight phorbol myristate acetate (PMA) pretreatment, suggesting that CaR-mediated activation of PLD depends largely upon stimulation of PKC.	Tetradecanoylphorbol Acetate	107-132	proline rich transmembrane protein 2	Homo sapiens	90-93
9144337-6	1997	Moreover, high Ca2+(o)-stimulated PLD activity was abolished following down-regulation of PKC by overnight phorbol myristate acetate (PMA) pretreatment, suggesting that CaR-mediated activation of PLD depends largely upon stimulation of PKC.	Tetradecanoylphorbol Acetate	107-132	calcium sensing receptor	Homo sapiens	169-172
9144337-6	1997	Moreover, high Ca2+(o)-stimulated PLD activity was abolished following down-regulation of PKC by overnight phorbol myristate acetate (PMA) pretreatment, suggesting that CaR-mediated activation of PLD depends largely upon stimulation of PKC.	Tetradecanoylphorbol Acetate	134-137	proline rich transmembrane protein 2	Homo sapiens	90-93
9144337-6	1997	Moreover, high Ca2+(o)-stimulated PLD activity was abolished following down-regulation of PKC by overnight phorbol myristate acetate (PMA) pretreatment, suggesting that CaR-mediated activation of PLD depends largely upon stimulation of PKC.	Tetradecanoylphorbol Acetate	134-137	calcium sensing receptor	Homo sapiens	169-172
9144337-6	1997	Moreover, high Ca2+(o)-stimulated PLD activity was abolished following down-regulation of PKC by overnight phorbol myristate acetate (PMA) pretreatment, suggesting that CaR-mediated activation of PLD depends largely upon stimulation of PKC.	Tetradecanoylphorbol Acetate	134-137	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	196-199
9144337-6	1997	Moreover, high Ca2+(o)-stimulated PLD activity was abolished following down-regulation of PKC by overnight phorbol myristate acetate (PMA) pretreatment, suggesting that CaR-mediated activation of PLD depends largely upon stimulation of PKC.	Tetradecanoylphorbol Acetate	134-137	proline rich transmembrane protein 2	Homo sapiens	236-239
9160089-7	1997	Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis.	Tetradecanoylphorbol Acetate	0-25	integrin subunit beta 2	Homo sapiens	105-109
9158547-6	1997	Although the R123lo cells respond poorly to receptor-dependent agonists, they can be triggered to proliferate and produce IFN gamma by the combination of PMA and ionomycin.	Tetradecanoylphorbol Acetate	154-157	interferon gamma	Mus musculus	122-131
9250823-2	1997	Exposure of Farage cells, derived from a human B-cell lymphoma, to phorbol 12-myristate 13-acetate (PMA) down-regulated CD21 and CD23 expression, while interleukin 4 (IL4) inhibited the expression of CD21 but augmented CD23 expression.	Tetradecanoylphorbol Acetate	67-98	complement C3d receptor 2	Homo sapiens	120-124
9250823-2	1997	Exposure of Farage cells, derived from a human B-cell lymphoma, to phorbol 12-myristate 13-acetate (PMA) down-regulated CD21 and CD23 expression, while interleukin 4 (IL4) inhibited the expression of CD21 but augmented CD23 expression.	Tetradecanoylphorbol Acetate	67-98	complement C3d receptor 2	Homo sapiens	200-204
9250823-2	1997	Exposure of Farage cells, derived from a human B-cell lymphoma, to phorbol 12-myristate 13-acetate (PMA) down-regulated CD21 and CD23 expression, while interleukin 4 (IL4) inhibited the expression of CD21 but augmented CD23 expression.	Tetradecanoylphorbol Acetate	100-103	complement C3d receptor 2	Homo sapiens	120-124
9250823-2	1997	Exposure of Farage cells, derived from a human B-cell lymphoma, to phorbol 12-myristate 13-acetate (PMA) down-regulated CD21 and CD23 expression, while interleukin 4 (IL4) inhibited the expression of CD21 but augmented CD23 expression.	Tetradecanoylphorbol Acetate	100-103	complement C3d receptor 2	Homo sapiens	200-204
13677669-8	1997	Similar desensitization of beta-AR and AC occurred after 1-2 hrs treatment of EC with histamine and platelet activating factor (stimulators of PI-turnover) and with phorbol myristate acetate (PK C activator).	Tetradecanoylphorbol Acetate	165-190	proline rich transmembrane protein 2	Homo sapiens	192-196
9129233-6	1997	TPA treatment dramatically increased mRNA levels of two other EGF receptor ligands, amphiregulin and heparin binding-EGF, however, in the skin of all three mouse lines.	Tetradecanoylphorbol Acetate	0-3	amphiregulin	Mus musculus	84-96
9111316-8	1997	In contrast to ionomycin treatment, exposure of cells to phorbol myristate acetate (PMA) plus anti-CD28 did not induce NFATc, indicating that under these conditions, interleukin-2 synthesis by these cells is apparently independent of NFATc.	Tetradecanoylphorbol Acetate	57-82	interleukin 2	Homo sapiens	166-179
9500150-11	1997	Pretreatment of C6 glioma cells with 1 microM phorbol myristate acetate (PMA) for 24 h completely blocked the subsequent stimulation of IL-6 release by PMA (20-250 nM) and partially blocked by 50% the TF5 stimulation of this cytokine.	Tetradecanoylphorbol Acetate	46-71	interleukin 6	Homo sapiens	136-140
9500150-11	1997	Pretreatment of C6 glioma cells with 1 microM phorbol myristate acetate (PMA) for 24 h completely blocked the subsequent stimulation of IL-6 release by PMA (20-250 nM) and partially blocked by 50% the TF5 stimulation of this cytokine.	Tetradecanoylphorbol Acetate	73-76	interleukin 6	Homo sapiens	136-140
9500150-11	1997	Pretreatment of C6 glioma cells with 1 microM phorbol myristate acetate (PMA) for 24 h completely blocked the subsequent stimulation of IL-6 release by PMA (20-250 nM) and partially blocked by 50% the TF5 stimulation of this cytokine.	Tetradecanoylphorbol Acetate	152-155	interleukin 6	Homo sapiens	136-140
9223226-7	1997	PMA caused a dose-related increase in EPBE adherence to fibronectin-coated plastic.	Tetradecanoylphorbol Acetate	0-3	fibronectin 1	Homo sapiens	56-67
9160089-7	1997	Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis.	Tetradecanoylphorbol Acetate	27-30	integrin subunit beta 2	Homo sapiens	105-109
9150279-3	1997	Treatments with 12-O-tetradecanoylphorbol-13-acetate (TPA), angiotensin II (ANG II) and endothelin-1 (ET-1) stimulated the PKC activity by 4-5-fold in PKC-alpha cDNA transfected MA-10 cells.	Tetradecanoylphorbol Acetate	16-52	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	76-82
9150279-3	1997	Treatments with 12-O-tetradecanoylphorbol-13-acetate (TPA), angiotensin II (ANG II) and endothelin-1 (ET-1) stimulated the PKC activity by 4-5-fold in PKC-alpha cDNA transfected MA-10 cells.	Tetradecanoylphorbol Acetate	16-52	protein kinase C, alpha	Mus musculus	123-126
9150279-3	1997	Treatments with 12-O-tetradecanoylphorbol-13-acetate (TPA), angiotensin II (ANG II) and endothelin-1 (ET-1) stimulated the PKC activity by 4-5-fold in PKC-alpha cDNA transfected MA-10 cells.	Tetradecanoylphorbol Acetate	16-52	protein kinase C, alpha	Mus musculus	151-160
9150279-3	1997	Treatments with 12-O-tetradecanoylphorbol-13-acetate (TPA), angiotensin II (ANG II) and endothelin-1 (ET-1) stimulated the PKC activity by 4-5-fold in PKC-alpha cDNA transfected MA-10 cells.	Tetradecanoylphorbol Acetate	54-57	protein kinase C, alpha	Mus musculus	123-126
9150279-3	1997	Treatments with 12-O-tetradecanoylphorbol-13-acetate (TPA), angiotensin II (ANG II) and endothelin-1 (ET-1) stimulated the PKC activity by 4-5-fold in PKC-alpha cDNA transfected MA-10 cells.	Tetradecanoylphorbol Acetate	54-57	protein kinase C, alpha	Mus musculus	151-160
9150279-4	1997	The pretreatment of PKC-alpha transfected cells with ANP significantly inhibited the TPA-, ANG II- and ET-1-stimulated PKC activity.	Tetradecanoylphorbol Acetate	85-88	protein kinase C, alpha	Mus musculus	20-29
9150279-4	1997	The pretreatment of PKC-alpha transfected cells with ANP significantly inhibited the TPA-, ANG II- and ET-1-stimulated PKC activity.	Tetradecanoylphorbol Acetate	85-88	protein kinase C, alpha	Mus musculus	20-23
9108402-4	1997	Most B-CLL cells were positive for CD6 and the expression of CD6 was increased after activation with Staphylococcus aureus Cowan I plus interleukin-2 or 12-O-tetradecanoylphorbol 13-acetate, although anti-CD6 antibodies did not increase proliferative responses to these stimuli.	Tetradecanoylphorbol Acetate	153-189	CD6 molecule	Homo sapiens	61-64
9099748-4	1997	Effects of both agonists on intra- and extracellular release were inhibited by the protein kinase C (PKC) inhibitor, Ro-31-8220, and PKC down-regulation by preincubation with TPA.	Tetradecanoylphorbol Acetate	175-178	proline rich transmembrane protein 2	Homo sapiens	133-136
9099748-8	1997	In contrast, down-regulation of PKC inhibited the synthesis response to TPA but not vasopressin.	Tetradecanoylphorbol Acetate	72-75	proline rich transmembrane protein 2	Homo sapiens	32-35
9099748-12	1997	Thus, the elevation of phospholipase D activity or activities induced by both TPA and vasopressin and the stimulation of translation by TPA involves PKC-alpha, -epsilon, and/or -delta.	Tetradecanoylphorbol Acetate	136-139	protein kinase C alpha	Homo sapiens	149-183
9141489-1	1997	Our recent studies have suggested that sphingosine, an endogenous protein kinase C (PKC) inhibitor, may mediate apoptosis induced by a phorbol ester (PMA) in human promyelocytic leukemia HL-60 cells [Ohta et al.	Tetradecanoylphorbol Acetate	150-153	proline rich transmembrane protein 2	Homo sapiens	66-82
9141489-1	1997	Our recent studies have suggested that sphingosine, an endogenous protein kinase C (PKC) inhibitor, may mediate apoptosis induced by a phorbol ester (PMA) in human promyelocytic leukemia HL-60 cells [Ohta et al.	Tetradecanoylphorbol Acetate	150-153	proline rich transmembrane protein 2	Homo sapiens	84-87
9108402-4	1997	Most B-CLL cells were positive for CD6 and the expression of CD6 was increased after activation with Staphylococcus aureus Cowan I plus interleukin-2 or 12-O-tetradecanoylphorbol 13-acetate, although anti-CD6 antibodies did not increase proliferative responses to these stimuli.	Tetradecanoylphorbol Acetate	153-189	CD6 molecule	Homo sapiens	61-64
9108029-8	1997	This process seems to be essential for AP-1 activation by redox modification because co-overexpression of TRX and Ref-1 in COS-7 cells potentiated AP-1 activity only after TRX was transported into the nucleus by phorbol 12-myristate 13 acetate treatment.	Tetradecanoylphorbol Acetate	212-243	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-43
9163343-2	1997	As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line.	Tetradecanoylphorbol Acetate	106-109	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-141
9163343-2	1997	As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line.	Tetradecanoylphorbol Acetate	106-109	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	143-146
9163343-2	1997	As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line.	Tetradecanoylphorbol Acetate	241-244	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-141
9163343-2	1997	As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line.	Tetradecanoylphorbol Acetate	241-244	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	143-146
9142932-9	1997	Furthermore, downregulation of PKC by 12-O-tetradecanoylphorbol-13-acetate (100 nM, 18 h) also blocked polycation-mediated PLD stimulation.	Tetradecanoylphorbol Acetate	38-74	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	123-126
9172156-1	1997	Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons.	Tetradecanoylphorbol Acetate	160-163	fibroblast growth factor 1	Homo sapiens	71-102
9172156-1	1997	Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons.	Tetradecanoylphorbol Acetate	160-163	fibroblast growth factor 1	Homo sapiens	104-108
9172156-1	1997	Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons.	Tetradecanoylphorbol Acetate	160-163	tyrosine hydroxylase	Homo sapiens	254-274
9172156-1	1997	Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons.	Tetradecanoylphorbol Acetate	160-163	tyrosine hydroxylase	Homo sapiens	276-278
9172156-1	1997	Previous studies have demonstrated that the synergistic interaction of acidic fibroblast growth factor (aFGF) and a number of co-activator molecules (dopamine, TPA, IBMX/forskolin) can induce the novel expression of the catecholamine biosynthetic enzyme tyrosine hydroxylase (TH) in non-TH-expressing neurons.	Tetradecanoylphorbol Acetate	160-163	tyrosine hydroxylase	Homo sapiens	287-289
9195048-2	1997	Induction of the JE gene by TNF alpha or serum was not completely inhibited by these antioxidants inhibited an increase in intracellular oxidized state of cells treated with TPA.	Tetradecanoylphorbol Acetate	174-177	tumor necrosis factor	Mus musculus	28-37
9106500-11	1997	When the thymocytes were activated with 12-O-tetradecanoylpholbol-13-acetate (TPA) and calcium ionophore A23187, the proportion of AC1+ cells increased remarkably and were detected not only in CD4+ cells but also in CD8+ cells.	Tetradecanoylphorbol Acetate	78-81	adenylate cyclase 1	Rattus norvegicus	131-134
9136936-4	1997	Using an immunostaining method that enables simultaneous detection of cytokines and phenotype, 56 +/- 6% CD34+ peripheral blood progenitor cells (PBPC) were found to contain cytoplasmic IL-8 after stimulation with phorbol myristate acetate + ionomycin for 90 min.	Tetradecanoylphorbol Acetate	214-239	CD34 molecule	Homo sapiens	105-109
9136936-4	1997	Using an immunostaining method that enables simultaneous detection of cytokines and phenotype, 56 +/- 6% CD34+ peripheral blood progenitor cells (PBPC) were found to contain cytoplasmic IL-8 after stimulation with phorbol myristate acetate + ionomycin for 90 min.	Tetradecanoylphorbol Acetate	214-239	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
9195048-7	1997	Gel shift analysis indicated that the nuclear factors that bound to this essential element contained NF kappa B, and that NF kappa B activity was stimulated by TPA and inhibited by PDTC.	Tetradecanoylphorbol Acetate	160-163	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	122-132
9195048-8	1997	These results suggest that active oxygen species are involved in induction of the JE gene caused by TPA in Balb 3T3 cells, through NF kappa B activation.	Tetradecanoylphorbol Acetate	100-103	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	131-141
9075734-7	1997	Down-regulation of PKC activity by long term 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment (24 h) diminished, but did not abolish, the effect of SP on VIP-stimulated cAMP production.	Tetradecanoylphorbol Acetate	83-86	vasoactive intestinal peptide	Rattus norvegicus	158-161
9075730-1	1997	GnRH-a as well as the protein kinase C (PKC) activator 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulated a sustained response of MAPK activity, whereas epidermal growth factor (EGF) stimulated a transient response.	Tetradecanoylphorbol Acetate	55-92	mitogen-activated protein kinase 1	Mus musculus	134-138
9075730-1	1997	GnRH-a as well as the protein kinase C (PKC) activator 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulated a sustained response of MAPK activity, whereas epidermal growth factor (EGF) stimulated a transient response.	Tetradecanoylphorbol Acetate	94-97	mitogen-activated protein kinase 1	Mus musculus	134-138
9075734-9	1997	TPA, which translocates PKC alpha, beta, and delta in lactotrophs, had a synergistic effect on cAMP formation induced by VIP, but did also, unlike SP, display cAMP rising abilities when cells were not exposed to VIP and forskolin.	Tetradecanoylphorbol Acetate	0-3	vasoactive intestinal peptide	Rattus norvegicus	121-124
9075730-3	1997	GnRH-a and TPA apparently activated mainly the MAPK isoform ERK1, as revealed by Mono-Q fast protein liquid chromatography followed by Western blotting as well as by gel kinase assay.	Tetradecanoylphorbol Acetate	11-14	mitogen-activated protein kinase 1	Mus musculus	47-51
9075730-4	1997	GnRH-a and TPA stimulated the tyrosine phosphorylation of several proteins, and this effect as well as the stimulation of MAPK activity were inhibited by the PKC inhibitor GF 109203X.	Tetradecanoylphorbol Acetate	11-14	mitogen-activated protein kinase 1	Mus musculus	122-126
9075734-9	1997	TPA, which translocates PKC alpha, beta, and delta in lactotrophs, had a synergistic effect on cAMP formation induced by VIP, but did also, unlike SP, display cAMP rising abilities when cells were not exposed to VIP and forskolin.	Tetradecanoylphorbol Acetate	0-3	vasoactive intestinal peptide	Rattus norvegicus	212-215
9075730-7	1997	Although Ca2+ ionophores have only a marginal stimulatory effect, the removal of Ca2+ markedly reduced MAPK activation by GnRH-a and TPA, but had no effect on GnRH-a and TPA stimulation of protein tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	133-136	mitogen-activated protein kinase 1	Mus musculus	103-107
9134496-4	1997	We examined the effects of cAMP and phorbol 12-myristate 13-acetate (PMA) on the transcription of the hCS-A and hCS-B genes.	Tetradecanoylphorbol Acetate	36-67	chorionic somatomammotropin hormone 2	Homo sapiens	112-117
9176098-3	1997	After monocytes were primed with lipopolysaccharide (LPS) or interferon-gamma (IFN-gamma) for 18 hr in suspension culture, they produced a high amount of superoxide (O2-) when triggered by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	189-214	interferon gamma	Homo sapiens	61-77
9176098-3	1997	After monocytes were primed with lipopolysaccharide (LPS) or interferon-gamma (IFN-gamma) for 18 hr in suspension culture, they produced a high amount of superoxide (O2-) when triggered by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	189-214	interferon gamma	Homo sapiens	79-88
9176121-1	1997	Non-lethal complement (C) attack on K562 cells has been shown to induce a transient resistance to lethal amounts of C. We have previously shown that incubation of K562 with phorbol 12-myristate 13-acetate (PMA) caused an increase in both CD59 expression and resistance to C killing and we were interested to examine whether non-lethal C attack caused a similar effect.	Tetradecanoylphorbol Acetate	173-204	CD59 molecule (CD59 blood group)	Homo sapiens	238-242
9176121-1	1997	Non-lethal complement (C) attack on K562 cells has been shown to induce a transient resistance to lethal amounts of C. We have previously shown that incubation of K562 with phorbol 12-myristate 13-acetate (PMA) caused an increase in both CD59 expression and resistance to C killing and we were interested to examine whether non-lethal C attack caused a similar effect.	Tetradecanoylphorbol Acetate	206-209	CD59 molecule (CD59 blood group)	Homo sapiens	238-242
9154298-13	1997	The increase in IL-6 luciferase activity occurs in the absence of the multiple response region, the area of the IL-6 promoter responsive to IL-1, TNF alpha, cyclic amp, and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	173-204	interleukin 6	Homo sapiens	16-20
9154298-13	1997	The increase in IL-6 luciferase activity occurs in the absence of the multiple response region, the area of the IL-6 promoter responsive to IL-1, TNF alpha, cyclic amp, and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	173-204	interleukin 6	Homo sapiens	112-116
9134496-4	1997	We examined the effects of cAMP and phorbol 12-myristate 13-acetate (PMA) on the transcription of the hCS-A and hCS-B genes.	Tetradecanoylphorbol Acetate	69-72	chorionic somatomammotropin hormone 2	Homo sapiens	112-117
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 beta	Homo sapiens	117-134
9103544-1	1997	Exposure to lipopolysaccharide (LPS) combined with phorbol-12-myristate-13-acetate (PMA) stimulates de novo synthesis of inducible nitric oxide synthase (NOS-2) in C6 glioma cells.	Tetradecanoylphorbol Acetate	51-82	nitric oxide synthase 2	Homo sapiens	154-159
9103544-1	1997	Exposure to lipopolysaccharide (LPS) combined with phorbol-12-myristate-13-acetate (PMA) stimulates de novo synthesis of inducible nitric oxide synthase (NOS-2) in C6 glioma cells.	Tetradecanoylphorbol Acetate	84-87	nitric oxide synthase 2	Homo sapiens	154-159
9103544-2	1997	Ethanol dose-dependently inhibits C6 cell NOS-2 activity, as measured by nitrite accumulation in culture medium, when present during LPS plus PMA treatment.	Tetradecanoylphorbol Acetate	142-145	nitric oxide synthase 2	Homo sapiens	42-47
9103544-5	1997	In contrast, NOS-2 enzymatic activity was significantly decreased in cytosolic extracts from cultures simultaneously exposed to ethanol and LPS plus PMA for 24 hr.	Tetradecanoylphorbol Acetate	149-152	nitric oxide synthase 2	Homo sapiens	13-18
9103544-8	1997	Subsequent experiments confirmed that 12-hr exposure to ethanol was sufficient to inhibit LPS/PMA-induced NOS-2 activity.	Tetradecanoylphorbol Acetate	94-97	nitric oxide synthase 2	Homo sapiens	106-111
9150350-5	1997	Both biomodulators alone were sufficient to promote TNF alpha release; however, the combination of TPA and LPS resulted in a synergistic increase of TNF alpha secretion.	Tetradecanoylphorbol Acetate	99-102	tumor necrosis factor	Homo sapiens	149-158
9119982-3	1997	Dose and time dependent increases in intracellular CB were seen when cells primed with phorbol ester (PMA) were cultured with IFN-gamma.	Tetradecanoylphorbol Acetate	102-105	interferon gamma	Homo sapiens	126-135
9365188-11	1997	However, removal of the serum or the addition of forskolin or phorbol ester (TPA) induced a rapid elevation of aromatase mRNA and the switching of aromatase transcripts to exon 1c in the cells, whereas TGFbeta almost abolished the expression of aromatase mRNA.	Tetradecanoylphorbol Acetate	77-80	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	111-120
9365188-11	1997	However, removal of the serum or the addition of forskolin or phorbol ester (TPA) induced a rapid elevation of aromatase mRNA and the switching of aromatase transcripts to exon 1c in the cells, whereas TGFbeta almost abolished the expression of aromatase mRNA.	Tetradecanoylphorbol Acetate	77-80	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	147-156
9365188-11	1997	However, removal of the serum or the addition of forskolin or phorbol ester (TPA) induced a rapid elevation of aromatase mRNA and the switching of aromatase transcripts to exon 1c in the cells, whereas TGFbeta almost abolished the expression of aromatase mRNA.	Tetradecanoylphorbol Acetate	77-80	transforming growth factor beta 1	Homo sapiens	202-209
9365188-11	1997	However, removal of the serum or the addition of forskolin or phorbol ester (TPA) induced a rapid elevation of aromatase mRNA and the switching of aromatase transcripts to exon 1c in the cells, whereas TGFbeta almost abolished the expression of aromatase mRNA.	Tetradecanoylphorbol Acetate	77-80	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	147-156
9168431-11	1997	Upregulation of c-kit in T-lymphoblastic cells could be demonstrated by the addition of IL-1 beta, TNF-alpha, TGF-beta or A23187, and downregulation by rhSCF or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	161-186	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	16-21
9168431-11	1997	Upregulation of c-kit in T-lymphoblastic cells could be demonstrated by the addition of IL-1 beta, TNF-alpha, TGF-beta or A23187, and downregulation by rhSCF or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	188-191	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	16-21
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 beta	Homo sapiens	136-144
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 beta	Homo sapiens	264-272
9058710-6	1997	Moreover, we found that CD44-mediated adhesion of CD34+ cells to HA could be enhanced by phorbol 12-myristate 13-acetate (PMA), the function-activating anti-CD44 monoclonal antibody H90, and cytokines such as granulocyte-monocyte colony-stimulating factor, interleukin-3 (IL-3), and stem cell factor.	Tetradecanoylphorbol Acetate	89-120	CD34 molecule	Homo sapiens	50-54
9106263-2	1997	In this study we report the effects of basic fibroblast growth factor (bFGF) and the protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), on beta-APP expression and secretion in SKNMC human neuroblastoma cells.	Tetradecanoylphorbol Acetate	113-144	amyloid beta precursor protein	Homo sapiens	155-163
9106263-2	1997	In this study we report the effects of basic fibroblast growth factor (bFGF) and the protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), on beta-APP expression and secretion in SKNMC human neuroblastoma cells.	Tetradecanoylphorbol Acetate	146-149	amyloid beta precursor protein	Homo sapiens	155-163
9136987-9	1997	Concomittantly, erbB2:EGFr heterodimer formation and c-src kinase activity were also elevated in TPA-treated epidermis.	Tetradecanoylphorbol Acetate	97-100	c-src tyrosine kinase	Mus musculus	53-65
9058710-6	1997	Moreover, we found that CD44-mediated adhesion of CD34+ cells to HA could be enhanced by phorbol 12-myristate 13-acetate (PMA), the function-activating anti-CD44 monoclonal antibody H90, and cytokines such as granulocyte-monocyte colony-stimulating factor, interleukin-3 (IL-3), and stem cell factor.	Tetradecanoylphorbol Acetate	122-125	CD34 molecule	Homo sapiens	50-54
9094105-7	1997	Spatial and temporal localization of PKC using confocal microscopy to visualize the PKC reporter dye, Rim-1, demonstrated localization of PKC to the lateral aspects of the forming second polar body after fertilization, or after artificial activation with calcium ionophore or PMA.	Tetradecanoylphorbol Acetate	276-279	regulating synaptic membrane exocytosis 1	Mus musculus	102-107
9150836-4	1997	Only one neonate of group B showed detectable in vitro synthesis of IL4 (45 pg/ml) after PHA + TPA stimulation.	Tetradecanoylphorbol Acetate	95-98	interleukin 4	Homo sapiens	68-71
9054554-1	1997	Upon exposure to 12-O-tetradecanoylphorbol 13-acetate (PMA), promonocyte-like U937 cells differentiate into macrophage-like cells and begin to express certain metalloproteinases and TIMP-1.	Tetradecanoylphorbol Acetate	17-53	TIMP metallopeptidase inhibitor 1	Homo sapiens	182-188
9054554-1	1997	Upon exposure to 12-O-tetradecanoylphorbol 13-acetate (PMA), promonocyte-like U937 cells differentiate into macrophage-like cells and begin to express certain metalloproteinases and TIMP-1.	Tetradecanoylphorbol Acetate	55-58	TIMP metallopeptidase inhibitor 1	Homo sapiens	182-188
9075429-8	1997	The increase in CD18 expression after beta-phorbol 12-myristate 13-acetate stimulation of neutrophils was similar in control and diabetic participants.	Tetradecanoylphorbol Acetate	38-74	integrin subunit beta 2	Homo sapiens	16-20
9099897-9	1997	Treatment of LNCaP and PC-3 cells with the phorbol ester 12-O-tetradecanoylphorbol (TPA) caused the same effect on mAAT activity and mRNA level as prolactin.	Tetradecanoylphorbol Acetate	84-87	prolactin	Homo sapiens	147-156
9061005-8	1997	Interestingly, phorbol myristate acetate and zymosan, agents which trigger the macrophage respiratory burst, were found to inhibit the PTP activity of BMM.	Tetradecanoylphorbol Acetate	15-40	protein tyrosine phosphatase, receptor type, U	Mus musculus	135-138
9060998-2	1997	Addition of either 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) or retinoic acid (RA) to HL-60 cells for 2 h inhibited PMA-stimulated PLA2 activity measured by [3H]AA release.	Tetradecanoylphorbol Acetate	113-116	phospholipase A2 group IB	Homo sapiens	128-132
9057109-7	1997	A PKC inhibitor (1 microM CGP 41 251) abolished PMA-induced secretion, but did not alter calcium-induced secretion.	Tetradecanoylphorbol Acetate	48-51	proline rich transmembrane protein 2	Homo sapiens	2-5
9048615-6	1997	TNF alpha action on PAI-1, like that of TGF alpha demonstrated previously, was masked by a preexposure to phorbol myristate acetate (a stimulator of protein kinase C) and strongly reduced by staurosporine (an inhibitor of the protein kinase C).	Tetradecanoylphorbol Acetate	106-131	tumor necrosis factor	Rattus norvegicus	0-9
9048615-6	1997	TNF alpha action on PAI-1, like that of TGF alpha demonstrated previously, was masked by a preexposure to phorbol myristate acetate (a stimulator of protein kinase C) and strongly reduced by staurosporine (an inhibitor of the protein kinase C).	Tetradecanoylphorbol Acetate	106-131	serpin family E member 1	Rattus norvegicus	20-25
9207756-10	1997	It can be concluded that the use of PMA, analogous to DAG, and ionophore A23187 (calcium increaser) in cultures of mitogen-activated T lymphocytes from LL patients induced the expression of the IL-2 gene, thus correcting the inadequate proliferation of T cells from LL patients.	Tetradecanoylphorbol Acetate	36-39	interleukin 2	Homo sapiens	194-198
9207756-0	1997	Effect of phorbol myristate acetate (PMA) and ionophore A23187 on interleukin-2 levels and proliferation of activated T lymphocytes from patients with lepromatous leprosy.	Tetradecanoylphorbol Acetate	10-35	interleukin 2	Homo sapiens	66-79
9207756-0	1997	Effect of phorbol myristate acetate (PMA) and ionophore A23187 on interleukin-2 levels and proliferation of activated T lymphocytes from patients with lepromatous leprosy.	Tetradecanoylphorbol Acetate	37-40	interleukin 2	Homo sapiens	66-79
9125669-3	1997	Activation of PKC with a phorbol ester, PMA (phorbol myristate acetate), induced a rapid and transient (1-4 h) increase in the levels of both 1.2- and 2.4-kb IL-6 transcripts in rat aortic SMCs (RASMC), as determined by Northern analysis, which was followed by increased release of bioactive IL-6, as determined by a B9 cell-proliferation assay.	Tetradecanoylphorbol Acetate	40-43	interleukin 6	Rattus norvegicus	158-162
9125669-3	1997	Activation of PKC with a phorbol ester, PMA (phorbol myristate acetate), induced a rapid and transient (1-4 h) increase in the levels of both 1.2- and 2.4-kb IL-6 transcripts in rat aortic SMCs (RASMC), as determined by Northern analysis, which was followed by increased release of bioactive IL-6, as determined by a B9 cell-proliferation assay.	Tetradecanoylphorbol Acetate	40-43	interleukin 6	Rattus norvegicus	292-296
9125669-3	1997	Activation of PKC with a phorbol ester, PMA (phorbol myristate acetate), induced a rapid and transient (1-4 h) increase in the levels of both 1.2- and 2.4-kb IL-6 transcripts in rat aortic SMCs (RASMC), as determined by Northern analysis, which was followed by increased release of bioactive IL-6, as determined by a B9 cell-proliferation assay.	Tetradecanoylphorbol Acetate	45-70	interleukin 6	Rattus norvegicus	158-162
9125669-3	1997	Activation of PKC with a phorbol ester, PMA (phorbol myristate acetate), induced a rapid and transient (1-4 h) increase in the levels of both 1.2- and 2.4-kb IL-6 transcripts in rat aortic SMCs (RASMC), as determined by Northern analysis, which was followed by increased release of bioactive IL-6, as determined by a B9 cell-proliferation assay.	Tetradecanoylphorbol Acetate	45-70	interleukin 6	Rattus norvegicus	292-296
9125669-4	1997	IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide.	Tetradecanoylphorbol Acetate	131-134	interleukin 6	Homo sapiens	68-72
9125669-4	1997	IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide.	Tetradecanoylphorbol Acetate	131-134	interleukin 6	Homo sapiens	143-147
9125669-4	1997	IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide.	Tetradecanoylphorbol Acetate	227-230	interleukin 6	Homo sapiens	68-72
9125669-4	1997	IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide.	Tetradecanoylphorbol Acetate	227-230	interleukin 6	Homo sapiens	143-147
9036924-7	1997	Pulse-chase experiments with 35S-labeled melanocytes revealed an approximately 3-fold increase in the half-life of neurofibromin in bFGF- or PMA-stimulated cells compared to controls.	Tetradecanoylphorbol Acetate	141-144	neurofibromin 1	Homo sapiens	115-128
9032396-0	1997	Induction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	113-138	CD4 molecule	Homo sapiens	91-94
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	39-75	interleukin 1 beta	Homo sapiens	155-163
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	39-75	interleukin 1 beta	Homo sapiens	252-260
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	39-75	interleukin 1 beta	Homo sapiens	252-260
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	77-80	interleukin 1 beta	Homo sapiens	155-163
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	77-80	interleukin 1 beta	Homo sapiens	252-260
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	77-80	interleukin 1 beta	Homo sapiens	252-260
9085940-4	1997	Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level.	Tetradecanoylphorbol Acetate	35-38	interleukin 1 beta	Homo sapiens	83-91
9085940-4	1997	Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level.	Tetradecanoylphorbol Acetate	35-38	interleukin 1 beta	Homo sapiens	179-187
9085940-4	1997	Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level.	Tetradecanoylphorbol Acetate	145-148	interleukin 1 beta	Homo sapiens	83-91
9085940-4	1997	Northern blot analysis showed that TPA treatment elicited a transient induction of IL-1beta mRNA expression, maximal after 12 h, indicating that TPA regulates dermal papilla cell IL-1beta production at the transcriptional level.	Tetradecanoylphorbol Acetate	145-148	interleukin 1 beta	Homo sapiens	179-187
9060454-5	1997	In plasma membrane fractions, as in whole cell lysates, CD18 became phosphorylated in cells exposed to PMA but not in untreated cells or cells treated with N-formyl-methionyl-leucyl-phenylalanine (fMLP).	Tetradecanoylphorbol Acetate	103-106	integrin subunit beta 2	Homo sapiens	56-60
9060454-5	1997	In plasma membrane fractions, as in whole cell lysates, CD18 became phosphorylated in cells exposed to PMA but not in untreated cells or cells treated with N-formyl-methionyl-leucyl-phenylalanine (fMLP).	Tetradecanoylphorbol Acetate	103-106	formyl peptide receptor 1	Homo sapiens	197-201
9060454-9	1997	Addition of intact specific granule membranes to the plasma membranes from PMA-treated neutrophils markedly decreased phosphorylation in both CD11b and CD18 subunits.	Tetradecanoylphorbol Acetate	75-78	integrin subunit beta 2	Homo sapiens	152-156
9032396-4	1997	Here we show that in HIV type 1-infected cells, phosphorylation of Nef increased 8- to 12-fold after treatment with phorbol myristate acetate and phytohemagglutinin (PMA/PHA).	Tetradecanoylphorbol Acetate	116-141	S100 calcium binding protein B	Homo sapiens	67-70
9032396-9	1997	In Nef-expressing cells, treatment with PMA enhanced downregulation of the CD4 serine triple mutant from the cell surface, suggesting that phosphorylation is important for Nef function.	Tetradecanoylphorbol Acetate	40-43	S100 calcium binding protein B	Homo sapiens	3-6
9032396-9	1997	In Nef-expressing cells, treatment with PMA enhanced downregulation of the CD4 serine triple mutant from the cell surface, suggesting that phosphorylation is important for Nef function.	Tetradecanoylphorbol Acetate	40-43	CD4 molecule	Homo sapiens	75-78
9032396-9	1997	In Nef-expressing cells, treatment with PMA enhanced downregulation of the CD4 serine triple mutant from the cell surface, suggesting that phosphorylation is important for Nef function.	Tetradecanoylphorbol Acetate	40-43	S100 calcium binding protein B	Homo sapiens	172-175
9066008-4	1997	Following stimulation with phorbolester (PMA), a 3-6 fold higher expression of uPA receptor over a period of up to 5 days could be observed by fluorescent activated cell-sorting as well as by direct ligand-binding of amino-terminal fragment of uPA or vitronectin.	Tetradecanoylphorbol Acetate	41-44	plasminogen activator, urokinase	Homo sapiens	79-82
9122616-6	1997	When IL-10 and IFN-gamma were added simultaneously to neutrophil culture, IL-10 dose-dependently reduced IFN-gamma-induced increase of CR3 expression, O(2)- production (in response to both FMLP and phorbol 12-myristate 13-acetate, or PMA) and ADCC, but did not change Fc gamma RI expression on phagocytes.	Tetradecanoylphorbol Acetate	198-229	interferon gamma	Homo sapiens	15-24
9122616-6	1997	When IL-10 and IFN-gamma were added simultaneously to neutrophil culture, IL-10 dose-dependently reduced IFN-gamma-induced increase of CR3 expression, O(2)- production (in response to both FMLP and phorbol 12-myristate 13-acetate, or PMA) and ADCC, but did not change Fc gamma RI expression on phagocytes.	Tetradecanoylphorbol Acetate	198-229	interferon gamma	Homo sapiens	105-114
9138284-3	1997	The Activator Protein-1 (AP-1) site at approximately -70 bp upstream of the transcriptional start site has long been thought to play a dominant role in the transcriptional activation of the MMP promoters, particularly in response to stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	250-275	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-23
9138284-3	1997	The Activator Protein-1 (AP-1) site at approximately -70 bp upstream of the transcriptional start site has long been thought to play a dominant role in the transcriptional activation of the MMP promoters, particularly in response to stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	250-275	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-29
9138284-3	1997	The Activator Protein-1 (AP-1) site at approximately -70 bp upstream of the transcriptional start site has long been thought to play a dominant role in the transcriptional activation of the MMP promoters, particularly in response to stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	277-280	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-23
9138284-3	1997	The Activator Protein-1 (AP-1) site at approximately -70 bp upstream of the transcriptional start site has long been thought to play a dominant role in the transcriptional activation of the MMP promoters, particularly in response to stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	277-280	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-29
9066008-4	1997	Following stimulation with phorbolester (PMA), a 3-6 fold higher expression of uPA receptor over a period of up to 5 days could be observed by fluorescent activated cell-sorting as well as by direct ligand-binding of amino-terminal fragment of uPA or vitronectin.	Tetradecanoylphorbol Acetate	41-44	plasminogen activator, urokinase	Homo sapiens	244-247
9038375-5	1997	Immunohistochemistry studies indicated that after treatment with TPA normal PKCalpha mainly translocated to the plasma membrane, but mutant PKCalpha translocated mainly to the perinuclear region and slightly to the nucleus.	Tetradecanoylphorbol Acetate	65-68	protein kinase C alpha	Homo sapiens	76-84
9038216-8	1997	H89, an inhibitor of cAMP-dependent protein kinase, dose dependently increased TNF production in phorbol myristate acetate-differentiated U937 cells in the absence (6.5-fold at 30 microM; p = 0.035), but not in the presence (p = 0.77) of SNAP.	Tetradecanoylphorbol Acetate	97-122	tumor necrosis factor	Homo sapiens	79-82
9020132-4	1997	We demonstrate here that TPA not only has markedly synergistic effects on insulin-induced PI-3 kinase activity, but it also can induce PI-3 kinase activity and the PI-3 phosphates by itself.	Tetradecanoylphorbol Acetate	25-28	insulin	Homo sapiens	74-81
9020132-5	1997	We also found that insulin, a PI-3 kinase activator, enhanced TPA-induced AP-1 trans-activation and transformation in JB6 promotion-sensitive cells.	Tetradecanoylphorbol Acetate	62-65	insulin	Homo sapiens	19-26
9085272-4	1997	In the present experiment, the activators of protein kinase C and the adenylate cyclase, PMA (5 nM) and forskolin (10 microM) respectively, have elevated the steady state levels of LH beta mRNA significantly by 18 h at the specific concentrations shown in the parenthesis.	Tetradecanoylphorbol Acetate	89-92	luteinizing hormone subunit beta	Rattus norvegicus	181-188
9085272-6	1997	Result showed that the ability of PMA or forskolin to elevate the LH beta mRNA levels was suppressed by the addition of actinomycin D, an inhibitor of transcription.	Tetradecanoylphorbol Acetate	34-37	luteinizing hormone subunit beta	Rattus norvegicus	66-73
9063450-2	1997	Two-dimensional mapping of tryptic phosphopeptides of 32P-labeled connexin 56 from primary chicken-lens cultures showed that treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) induced an increase in phosphorylation of connexin 56 at specific constitutively phosphorylated sites.	Tetradecanoylphorbol Acetate	140-176	gap junction protein alpha 3	Gallus gallus	66-77
9063450-2	1997	Two-dimensional mapping of tryptic phosphopeptides of 32P-labeled connexin 56 from primary chicken-lens cultures showed that treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) induced an increase in phosphorylation of connexin 56 at specific constitutively phosphorylated sites.	Tetradecanoylphorbol Acetate	140-176	gap junction protein alpha 3	Gallus gallus	225-236
9063450-2	1997	Two-dimensional mapping of tryptic phosphopeptides of 32P-labeled connexin 56 from primary chicken-lens cultures showed that treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) induced an increase in phosphorylation of connexin 56 at specific constitutively phosphorylated sites.	Tetradecanoylphorbol Acetate	178-181	gap junction protein alpha 3	Gallus gallus	66-77
9063450-2	1997	Two-dimensional mapping of tryptic phosphopeptides of 32P-labeled connexin 56 from primary chicken-lens cultures showed that treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) induced an increase in phosphorylation of connexin 56 at specific constitutively phosphorylated sites.	Tetradecanoylphorbol Acetate	178-181	gap junction protein alpha 3	Gallus gallus	225-236
9063450-6	1997	It is suggested that phosphorylation of connexin 56 at S118 is involved in the TPA-induced decrease in intercellular communication and acceleration of connexin 56 degradation.	Tetradecanoylphorbol Acetate	79-82	gap junction protein alpha 3	Gallus gallus	40-51
9063450-6	1997	It is suggested that phosphorylation of connexin 56 at S118 is involved in the TPA-induced decrease in intercellular communication and acceleration of connexin 56 degradation.	Tetradecanoylphorbol Acetate	79-82	gap junction protein alpha 3	Gallus gallus	151-162
9045886-8	1997	This activation was PKC-dependent since phorbol 12-myristate 13-acetate (PMA) promoted down-regulation of PKC-eliminated MAP kinase activation by ATP or UTP.	Tetradecanoylphorbol Acetate	40-71	protein kinase C alpha	Homo sapiens	20-23
9045886-8	1997	This activation was PKC-dependent since phorbol 12-myristate 13-acetate (PMA) promoted down-regulation of PKC-eliminated MAP kinase activation by ATP or UTP.	Tetradecanoylphorbol Acetate	40-71	protein kinase C alpha	Homo sapiens	106-109
9045886-8	1997	This activation was PKC-dependent since phorbol 12-myristate 13-acetate (PMA) promoted down-regulation of PKC-eliminated MAP kinase activation by ATP or UTP.	Tetradecanoylphorbol Acetate	73-76	protein kinase C alpha	Homo sapiens	20-23
9045886-8	1997	This activation was PKC-dependent since phorbol 12-myristate 13-acetate (PMA) promoted down-regulation of PKC-eliminated MAP kinase activation by ATP or UTP.	Tetradecanoylphorbol Acetate	73-76	protein kinase C alpha	Homo sapiens	106-109
9045886-9	1997	Treatment of cells with the MAP kinase cascade inhibitor PD098059, the PKC inhibitor GF109203X, or down-regulation of PKC by PMA treatment, all suppressed AA release promoted by ATP or UTP, suggesting that both MAP kinase and PKC are involved in the regulation of cPLA2 by P2U receptors.	Tetradecanoylphorbol Acetate	125-128	protein kinase C alpha	Homo sapiens	118-121
9045886-9	1997	Treatment of cells with the MAP kinase cascade inhibitor PD098059, the PKC inhibitor GF109203X, or down-regulation of PKC by PMA treatment, all suppressed AA release promoted by ATP or UTP, suggesting that both MAP kinase and PKC are involved in the regulation of cPLA2 by P2U receptors.	Tetradecanoylphorbol Acetate	125-128	protein kinase C alpha	Homo sapiens	118-121
9045886-12	1997	This conclusion is further supported by data showing that PMA-promoted AA release, but not MAP kinase activation, was suppressed in cells in which PKCalpha expression was decreased by antisense transfection.	Tetradecanoylphorbol Acetate	58-61	protein kinase C alpha	Homo sapiens	147-155
9037208-5	1997	We also demonstrate the u-PA treatment potentiated phorbol ester (PMA)-mediated induction of PAI-2 mRNA, indicating that u-PA binding produces a bone fide response in vivo.	Tetradecanoylphorbol Acetate	66-69	plasminogen activator, urokinase	Homo sapiens	24-28
9013617-3	1997	Ii chains visualized with luminal and cytoplasmic directed antibodies appeared in early endosomal compartments accessible to transferrin in response to phorbol 12-myristate 13-acetate treatment, whereas transmembrane Ii degradation products equivalent to the p12 Ii fragments were colocalized with the B cell receptors internalized after cross-linking.	Tetradecanoylphorbol Acetate	152-183	transferrin	Homo sapiens	125-136
9115810-3	1997	Pretreatment of ACH-2 T cells by NAC followed by stimulation with PMA, TNF-alpha, or hydrogen peroxide (H2O2) resulted in strong suppression of NF-kappa B activation.	Tetradecanoylphorbol Acetate	66-69	nuclear factor kappa B subunit 1	Homo sapiens	144-154
9037208-5	1997	We also demonstrate the u-PA treatment potentiated phorbol ester (PMA)-mediated induction of PAI-2 mRNA, indicating that u-PA binding produces a bone fide response in vivo.	Tetradecanoylphorbol Acetate	66-69	plasminogen activator, urokinase	Homo sapiens	121-125
9124379-5	1997	Transcriptional regulation of IL-2 was investigated with a transgenic human AEC line, 16HBE/IL-2 luciferase; there is constitutive IL-2 transcription at rest, and IL-2 transcription is enhanced 8-fold by PMA and 25-fold by PMA + histamine.	Tetradecanoylphorbol Acetate	204-207	interleukin 2	Homo sapiens	30-34
9089652-6	1997	Activation of PKC by 2-O-tetradecanoyl phorbol 13-acetate (TPA) also stimulated ET-1 secretion in MCF-7 cells.	Tetradecanoylphorbol Acetate	59-62	endothelin 1	Homo sapiens	80-84
9124324-4	1997	A PKC-activating phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced IL-6 synthesis.	Tetradecanoylphorbol Acetate	32-68	interleukin 6	Mus musculus	84-88
9124324-4	1997	A PKC-activating phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced IL-6 synthesis.	Tetradecanoylphorbol Acetate	70-73	interleukin 6	Mus musculus	84-88
9124324-6	1997	The synthesis of IL-6 stimulated by a combination of PGF2alpha and TPA was not additive.	Tetradecanoylphorbol Acetate	67-70	interleukin 6	Mus musculus	17-21
9124324-7	1997	Staurosporine, an inhibitor for protein kinases that suppressed the TPA-induced IL-6 synthesis, significantly inhibited the PGF2alpha-induced IL-6 synthesis.	Tetradecanoylphorbol Acetate	68-71	interleukin 6	Mus musculus	80-84
9124324-7	1997	Staurosporine, an inhibitor for protein kinases that suppressed the TPA-induced IL-6 synthesis, significantly inhibited the PGF2alpha-induced IL-6 synthesis.	Tetradecanoylphorbol Acetate	68-71	interleukin 6	Mus musculus	142-146
9124379-3	1997	IL-2 mRNA is present constitutively in AEC and is enhanced twofold after stimulation with phorbol 12-myristate 13-acetate (PMA; 20 ng/ml) + histamine (2 mM).	Tetradecanoylphorbol Acetate	90-121	interleukin 2	Homo sapiens	0-4
9065603-5	1997	Incubation with phorbol-12-myristate-13-acetate led to a significant increase (p &lt; 0.005) of LDL-R mRNA in ER+ cells, whereas in ER- cells LDL-R mRNA levels remained merely unchanged.	Tetradecanoylphorbol Acetate	16-47	estrogen receptor 1	Homo sapiens	110-112
9124379-3	1997	IL-2 mRNA is present constitutively in AEC and is enhanced twofold after stimulation with phorbol 12-myristate 13-acetate (PMA; 20 ng/ml) + histamine (2 mM).	Tetradecanoylphorbol Acetate	123-126	interleukin 2	Homo sapiens	0-4
9124379-4	1997	Normal human AEC secrete IL-2 at rest (7 pg/ml), and IL-2 secretion is increased threefold after stimulation with PMA + histamine; this increase is inhibited by dexamethasone and diphenhydramine.	Tetradecanoylphorbol Acetate	114-117	interleukin 2	Homo sapiens	53-57
9081683-5	1997	Short-term incubation with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate, which inhibits thrombin-induced IP generation, did not affect the IP response to pervanadate.	Tetradecanoylphorbol Acetate	45-81	coagulation factor II, thrombin	Homo sapiens	98-106
9032469-1	1997	Activation of P388D1 macrophages by phorbol myristate acetate (PMA) resulted in the translocation of the protein kinase C (PKC) isoforms alpha, delta, and epsilon from the cytosol to membranes.	Tetradecanoylphorbol Acetate	36-61	protein kinase C alpha	Homo sapiens	105-162
9032469-1	1997	Activation of P388D1 macrophages by phorbol myristate acetate (PMA) resulted in the translocation of the protein kinase C (PKC) isoforms alpha, delta, and epsilon from the cytosol to membranes.	Tetradecanoylphorbol Acetate	63-66	protein kinase C alpha	Homo sapiens	105-162
9040941-6	1997	Because WASP also binds to Ash/Grb2 SH3 domains and the association of Ash/Grb2 and Shc is induced by 12-O-tetradecanoylphorbol 13-acetate treatment, a signaling pathway, PKC-tyrosine kinase-Shc-Ash/Grb2-WASP, is suggested for regulating megakaryocyte differentiation.	Tetradecanoylphorbol Acetate	102-138	growth factor receptor bound protein 2	Homo sapiens	27-30
9040941-6	1997	Because WASP also binds to Ash/Grb2 SH3 domains and the association of Ash/Grb2 and Shc is induced by 12-O-tetradecanoylphorbol 13-acetate treatment, a signaling pathway, PKC-tyrosine kinase-Shc-Ash/Grb2-WASP, is suggested for regulating megakaryocyte differentiation.	Tetradecanoylphorbol Acetate	102-138	growth factor receptor bound protein 2	Homo sapiens	31-35
9040941-6	1997	Because WASP also binds to Ash/Grb2 SH3 domains and the association of Ash/Grb2 and Shc is induced by 12-O-tetradecanoylphorbol 13-acetate treatment, a signaling pathway, PKC-tyrosine kinase-Shc-Ash/Grb2-WASP, is suggested for regulating megakaryocyte differentiation.	Tetradecanoylphorbol Acetate	102-138	growth factor receptor bound protein 2	Homo sapiens	71-74
9040941-6	1997	Because WASP also binds to Ash/Grb2 SH3 domains and the association of Ash/Grb2 and Shc is induced by 12-O-tetradecanoylphorbol 13-acetate treatment, a signaling pathway, PKC-tyrosine kinase-Shc-Ash/Grb2-WASP, is suggested for regulating megakaryocyte differentiation.	Tetradecanoylphorbol Acetate	102-138	growth factor receptor bound protein 2	Homo sapiens	75-79
9040941-6	1997	Because WASP also binds to Ash/Grb2 SH3 domains and the association of Ash/Grb2 and Shc is induced by 12-O-tetradecanoylphorbol 13-acetate treatment, a signaling pathway, PKC-tyrosine kinase-Shc-Ash/Grb2-WASP, is suggested for regulating megakaryocyte differentiation.	Tetradecanoylphorbol Acetate	102-138	growth factor receptor bound protein 2	Homo sapiens	71-74
9040941-6	1997	Because WASP also binds to Ash/Grb2 SH3 domains and the association of Ash/Grb2 and Shc is induced by 12-O-tetradecanoylphorbol 13-acetate treatment, a signaling pathway, PKC-tyrosine kinase-Shc-Ash/Grb2-WASP, is suggested for regulating megakaryocyte differentiation.	Tetradecanoylphorbol Acetate	102-138	growth factor receptor bound protein 2	Homo sapiens	75-79
9012737-10	1997	The fatty acids also inhibited the expression of ICAM-1 and E-selectin induced by phorbol 12-myristate 13-acetate, showing that inhibition occurred at a post-TNF-alpha receptor binding level.	Tetradecanoylphorbol Acetate	82-113	tumor necrosis factor	Homo sapiens	158-167
9071558-2	1997	The PKC activator phorbol-12-myristate 13-acetate (PMA) increased proliferation and inhibited TNF-induced cytotoxicity of L929 cells.	Tetradecanoylphorbol Acetate	18-49	protein kinase C, alpha	Mus musculus	4-7
9040943-3	1997	In this study, we investigated the physiological relevance of MDR1 gene regulation by NF-IL6 in response to PMA (phorbol 12-myristate 13-acetate)-induced differentiation.	Tetradecanoylphorbol Acetate	108-111	ATP binding cassette subfamily B member 1	Homo sapiens	62-66
9040943-3	1997	In this study, we investigated the physiological relevance of MDR1 gene regulation by NF-IL6 in response to PMA (phorbol 12-myristate 13-acetate)-induced differentiation.	Tetradecanoylphorbol Acetate	113-144	ATP binding cassette subfamily B member 1	Homo sapiens	62-66
9071558-2	1997	The PKC activator phorbol-12-myristate 13-acetate (PMA) increased proliferation and inhibited TNF-induced cytotoxicity of L929 cells.	Tetradecanoylphorbol Acetate	18-49	tumor necrosis factor	Mus musculus	94-97
9071558-2	1997	The PKC activator phorbol-12-myristate 13-acetate (PMA) increased proliferation and inhibited TNF-induced cytotoxicity of L929 cells.	Tetradecanoylphorbol Acetate	51-54	protein kinase C, alpha	Mus musculus	4-7
9071558-2	1997	The PKC activator phorbol-12-myristate 13-acetate (PMA) increased proliferation and inhibited TNF-induced cytotoxicity of L929 cells.	Tetradecanoylphorbol Acetate	51-54	tumor necrosis factor	Mus musculus	94-97
9003008-9	1997	Moreover, the phorbol ester phorbol 12-myristate 13-acetate mimicked most of the effects of AngII in BAC and decreased both AT2-binding sites and mRNA on PC12W cells, indicating that the hormonal regulation of both AT1 and AT2 receptors is mediated through protein kinase C activation.	Tetradecanoylphorbol Acetate	28-59	angiotensinogen	Rattus norvegicus	92-97
9071558-8	1997	Stimulation with PMA caused a strong translocation of PKC-alpha but not zeta to the membrane.	Tetradecanoylphorbol Acetate	17-20	protein kinase C, alpha	Mus musculus	54-63
9081220-1	1997	Previously, we have shown that IGF-1, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and aurintricarboxylic acid (ATA) protected MCF-7 cells against death induced by the protein synthesis inhibitor cycloheximide (CHX).	Tetradecanoylphorbol Acetate	94-97	insulin like growth factor 1	Homo sapiens	31-36
9045910-6	1997	Pre-incubation of CD4+ T lymphocytes in the presence of anti-CD4 mAb or gp160 inhibits the activation of JNK in response to phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	124-155	CD4 molecule	Homo sapiens	18-21
9045910-6	1997	Pre-incubation of CD4+ T lymphocytes in the presence of anti-CD4 mAb or gp160 inhibits the activation of JNK in response to phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	124-155	CD4 molecule	Homo sapiens	61-64
9045910-6	1997	Pre-incubation of CD4+ T lymphocytes in the presence of anti-CD4 mAb or gp160 inhibits the activation of JNK in response to phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	124-155	mitogen-activated protein kinase 8	Homo sapiens	105-108
9143940-4	1997	PMA + Ionomycin induced CD70 on the large majority of CD8+ cells, but only on a minority of CD4+ cells (P &lt; 0.002), and among these, preferentially on the CD45R0+ subset compared with the CD45RA+.	Tetradecanoylphorbol Acetate	0-3	CD70 molecule	Homo sapiens	24-28
9013765-3	1997	In contrast to cells expressing rLHR-wt, which respond to hCG or phorbol 12-myristate 13-acetate stimulation with an increase in rLHR phosphorylation, the phosphorylation of rLHR in cells expressing rLHR-5S/T--&gt;A is severely blunted.	Tetradecanoylphorbol Acetate	65-96	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	32-36
9003041-3	1997	We found that when the active beta from of 4 beta-12-O-tetradecanoylphorbol 13-acetate (TPA), but not the inactive alpha analogue, was incubated in the presence of aFGF, basic FGF, or brain-derived neurotrophic factor, TH expression was initiated.	Tetradecanoylphorbol Acetate	88-91	fibroblast growth factor 1	Homo sapiens	164-168
9003041-3	1997	We found that when the active beta from of 4 beta-12-O-tetradecanoylphorbol 13-acetate (TPA), but not the inactive alpha analogue, was incubated in the presence of aFGF, basic FGF, or brain-derived neurotrophic factor, TH expression was initiated.	Tetradecanoylphorbol Acetate	88-91	tyrosine hydroxylase	Homo sapiens	219-221
9003041-6	1997	Conversely, inhibitors of protein kinases, such as H7, H8, or H89, prevented the expression of TH by aFGF and TPA.	Tetradecanoylphorbol Acetate	110-113	tyrosine hydroxylase	Homo sapiens	95-97
21533367-3	1997	In the study reported here we compared the effect of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and non-phorbol ester tumor promoters such as okadaic acid, chrysarobin, and benzoyl peroxide on the levels of GR protein and mRNA in SENCAR mouse epidermis.	Tetradecanoylphorbol Acetate	53-90	nuclear receptor subfamily 3, group C, member 1	Mus musculus	208-210
21533367-5	1997	We also found that TPA and okadaic acid inhibited GR expression in keratinocyte cell line.	Tetradecanoylphorbol Acetate	19-22	nuclear receptor subfamily 3, group C, member 1	Mus musculus	50-52
9041048-8	1997	The effect of PTH could be mimicked by the cAMP analogs Bt2 cAMP and forskolin, but not by PTH fragment 3-34, calcium ionophore A23187, or by the PKC activator phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	160-191	parathyroid hormone	Rattus norvegicus	14-17
9013765-3	1997	In contrast to cells expressing rLHR-wt, which respond to hCG or phorbol 12-myristate 13-acetate stimulation with an increase in rLHR phosphorylation, the phosphorylation of rLHR in cells expressing rLHR-5S/T--&gt;A is severely blunted.	Tetradecanoylphorbol Acetate	65-96	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	129-133
9013765-3	1997	In contrast to cells expressing rLHR-wt, which respond to hCG or phorbol 12-myristate 13-acetate stimulation with an increase in rLHR phosphorylation, the phosphorylation of rLHR in cells expressing rLHR-5S/T--&gt;A is severely blunted.	Tetradecanoylphorbol Acetate	65-96	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	129-133
9013765-3	1997	In contrast to cells expressing rLHR-wt, which respond to hCG or phorbol 12-myristate 13-acetate stimulation with an increase in rLHR phosphorylation, the phosphorylation of rLHR in cells expressing rLHR-5S/T--&gt;A is severely blunted.	Tetradecanoylphorbol Acetate	65-96	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	129-133
9203625-8	1997	This reduction in PKC-alpha was sufficient to inhibit the reduction of bradykinin-induced calcium mobilization by TPA.	Tetradecanoylphorbol Acetate	114-117	protein kinase C alpha	Homo sapiens	18-27
9203625-3	1997	12-O-Tetradecanoylphorbol-13-acetate (TPA), a potent activator of PKC, is known to reduce the amplitude of agonist-induced calcium mobilization in various cell lines.	Tetradecanoylphorbol Acetate	0-36	protein kinase C alpha	Homo sapiens	66-69
9203625-8	1997	This reduction in PKC-alpha was sufficient to inhibit the reduction of bradykinin-induced calcium mobilization by TPA.	Tetradecanoylphorbol Acetate	114-117	kininogen 1	Homo sapiens	71-81
9203625-3	1997	12-O-Tetradecanoylphorbol-13-acetate (TPA), a potent activator of PKC, is known to reduce the amplitude of agonist-induced calcium mobilization in various cell lines.	Tetradecanoylphorbol Acetate	38-41	protein kinase C alpha	Homo sapiens	66-69
9203625-9	1997	This finding is corroborated by the use of staurosporine, a nonselective PKC inhibitor, that prevented the effect of TPA.	Tetradecanoylphorbol Acetate	117-120	protein kinase C alpha	Homo sapiens	73-76
9157598-3	1997	Differentiation of MEG-01 cells induced by 100 nM 12-O-tetradecanoylphorbol-13-acetate revealed the considerable increases in mRNA expression of rap1B, rab3B, rab4, ram and ran whereas the levels of rap2B, rhoA and rac1 decreased.	Tetradecanoylphorbol Acetate	50-86	RAB4A, member RAS oncogene family	Homo sapiens	159-163
9157598-3	1997	Differentiation of MEG-01 cells induced by 100 nM 12-O-tetradecanoylphorbol-13-acetate revealed the considerable increases in mRNA expression of rap1B, rab3B, rab4, ram and ran whereas the levels of rap2B, rhoA and rac1 decreased.	Tetradecanoylphorbol Acetate	50-86	ras homolog family member A	Homo sapiens	206-210
8999940-0	1997	Activation of 12-O-tetradecanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinases.	Tetradecanoylphorbol Acetate	14-50	mitogen-activated protein kinase 8	Homo sapiens	151-172
9042534-4	1997	First, it was shown that THP-1 cells could be induced to secrete significant amounts of TNF-alpha by interleukin-1, lipopolysaccharide, interferon-gamma (IFN-gamma) and PMA alone or in combination with each other.	Tetradecanoylphorbol Acetate	169-172	tumor necrosis factor	Homo sapiens	88-97
9042534-7	1997	The cellular action of A beta (1-40) appears to involve protein kinase C since pretreatment of THP-1 cells by PMA or the protein kinase C inhibitor H-7 diminished the cellular response to A beta (1-40).	Tetradecanoylphorbol Acetate	110-113	amyloid beta precursor protein	Homo sapiens	23-29
9042534-7	1997	The cellular action of A beta (1-40) appears to involve protein kinase C since pretreatment of THP-1 cells by PMA or the protein kinase C inhibitor H-7 diminished the cellular response to A beta (1-40).	Tetradecanoylphorbol Acetate	110-113	amyloid beta precursor protein	Homo sapiens	188-194
8999923-9	1997	However, phorbol 12-myristate 13-acetate treatment had only a limited effect on EGF binding and EGF-stimulated tyrosine kinase activity in cells expressing EGFR/RET chimeras.	Tetradecanoylphorbol Acetate	9-40	ret proto-oncogene	Mus musculus	161-164
9016559-1	1997	Tissue-type plasminogen activator (t-PA) gene expression in human endothelial cells and HeLa cells is stimulated by the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) at the level of transcription.	Tetradecanoylphorbol Acetate	147-178	plasminogen activator, tissue type	Homo sapiens	0-33
9000576-1	1997	Growth arrest and differentiation of leukemic cells by phorbol 12-myristate 13-acetate (PMA) is accompanied by p53-independent activation of p21WAF1/CIP1 and c-myc down-regulation.	Tetradecanoylphorbol Acetate	55-86	tumor protein p53	Homo sapiens	111-114
9000576-1	1997	Growth arrest and differentiation of leukemic cells by phorbol 12-myristate 13-acetate (PMA) is accompanied by p53-independent activation of p21WAF1/CIP1 and c-myc down-regulation.	Tetradecanoylphorbol Acetate	55-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	149-153
9000576-1	1997	Growth arrest and differentiation of leukemic cells by phorbol 12-myristate 13-acetate (PMA) is accompanied by p53-independent activation of p21WAF1/CIP1 and c-myc down-regulation.	Tetradecanoylphorbol Acetate	88-91	tumor protein p53	Homo sapiens	111-114
9000576-1	1997	Growth arrest and differentiation of leukemic cells by phorbol 12-myristate 13-acetate (PMA) is accompanied by p53-independent activation of p21WAF1/CIP1 and c-myc down-regulation.	Tetradecanoylphorbol Acetate	88-91	cyclin dependent kinase inhibitor 1A	Homo sapiens	149-153
8999961-5	1997	We demonstrate that concanavalin A inhibits cyclin D-Cdk4 activity by decreasing the amount of cyclin D. The inhibition of cyclin E-Cdk2 by both concanavalin A and PMA is due to increased binding of the Cdk inhibitor p21 to this complex.	Tetradecanoylphorbol Acetate	164-167	cyclin-dependent kinase 4	Mus musculus	53-57
9037504-3	1997	In the present study, the effects of 12-O-tetradecanoylphorbol 13-acetate (TPA), dibutyryl cyclic AMP (Bt2cAMP) or dexamethasone (DEX) on expression of LC1 were investigated by a sandwich enzyme immunoassay and reverse transcription polymerase chain reaction (RT-PCR) in rat astrocytoma (C6) cells.	Tetradecanoylphorbol Acetate	37-73	annexin A1	Rattus norvegicus	152-155
9037504-4	1997	Time-dependent experiments revealed that the intracellular protein content and the mRNA of rat LC1 increased significantly 4 h after TPA (10 mM) or DEX (1 microM) addition.	Tetradecanoylphorbol Acetate	133-136	annexin A1	Rattus norvegicus	95-98
9037504-5	1997	TPA and DEX elicited a prominent induction of LC1 at 10(-8) M and 10(-6) M, respectively.	Tetradecanoylphorbol Acetate	0-3	annexin A1	Rattus norvegicus	46-49
9016559-1	1997	Tissue-type plasminogen activator (t-PA) gene expression in human endothelial cells and HeLa cells is stimulated by the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) at the level of transcription.	Tetradecanoylphorbol Acetate	147-178	plasminogen activator, tissue type	Homo sapiens	35-39
9016559-1	1997	Tissue-type plasminogen activator (t-PA) gene expression in human endothelial cells and HeLa cells is stimulated by the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) at the level of transcription.	Tetradecanoylphorbol Acetate	180-183	plasminogen activator, tissue type	Homo sapiens	0-33
9016559-1	1997	Tissue-type plasminogen activator (t-PA) gene expression in human endothelial cells and HeLa cells is stimulated by the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) at the level of transcription.	Tetradecanoylphorbol Acetate	180-183	plasminogen activator, tissue type	Homo sapiens	35-39
9030717-6	1997	The time course of uPA-catalyzed cleavage of cell-bound uPAR was studied using U937 cells stimulated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	106-137	plasminogen activator, urokinase	Homo sapiens	19-22
9202885-6	1997	Distinct regions of the proximal promoter respond to a wide array of signals such as phorbol myristate acetate (PMA) and Ca2+ ionophore or phytohemaglutinin (PHA), CD28 activation, human T leukemia virus (HTLV)-1 tax, TNF, and interleukin 1 (IL-1).	Tetradecanoylphorbol Acetate	112-115	tumor necrosis factor	Homo sapiens	218-221
8995230-4	1997	TPA treatment of L epsilon delta, cells that overexpressed the PKC-epsilon delta chimera, induced a dramatically increased cell volume, surface adherence, surface expression of Mac-1 and Mac-3, lysozyme production, and phagocytosis.	Tetradecanoylphorbol Acetate	0-3	integrin alpha M	Mus musculus	177-182
9547543-0	1997	Induction of prostaglandin endoperoxide synthase-1 (COX-1) in a human promonocytic cell line by treatment with the differentiating agent TPA.	Tetradecanoylphorbol Acetate	137-140	prostaglandin-endoperoxide synthase 1	Homo sapiens	13-50
9192070-9	1997	Co-culture of blastemas with spinal ganglia partially reduces the decline in PKC activity, and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate, a direct activator of PKC, also prevents the fall in membrane-bound PKC activity while stimulating blastema cell proliferation, in vitro.	Tetradecanoylphorbol Acetate	113-149	proline rich transmembrane protein 2	Homo sapiens	173-176
9192070-9	1997	Co-culture of blastemas with spinal ganglia partially reduces the decline in PKC activity, and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate, a direct activator of PKC, also prevents the fall in membrane-bound PKC activity while stimulating blastema cell proliferation, in vitro.	Tetradecanoylphorbol Acetate	113-149	proline rich transmembrane protein 2	Homo sapiens	173-176
9863501-3	1997	These observations can be linked with the inhibition of NF-kappa B activation when uninfected monocytes are induced by either tumor necrosis factor alpha (TNF-alpha) phorbol 12-myristate 13-acetate (PMA) or lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	166-197	nuclear factor kappa B subunit 1	Homo sapiens	56-66
9863501-3	1997	These observations can be linked with the inhibition of NF-kappa B activation when uninfected monocytes are induced by either tumor necrosis factor alpha (TNF-alpha) phorbol 12-myristate 13-acetate (PMA) or lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	166-197	tumor necrosis factor	Homo sapiens	126-153
9863501-3	1997	These observations can be linked with the inhibition of NF-kappa B activation when uninfected monocytes are induced by either tumor necrosis factor alpha (TNF-alpha) phorbol 12-myristate 13-acetate (PMA) or lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	166-197	tumor necrosis factor	Homo sapiens	155-164
9863501-3	1997	These observations can be linked with the inhibition of NF-kappa B activation when uninfected monocytes are induced by either tumor necrosis factor alpha (TNF-alpha) phorbol 12-myristate 13-acetate (PMA) or lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	199-202	nuclear factor kappa B subunit 1	Homo sapiens	56-66
9067639-5	1997	Downregulation of protein kinase C (PKC) alpha and epsilon isoforms by pretreatment of fibroblasts for 48 h with phorbol 12-myristate 13-acetate (PMA), markedly attenuated both thrombin and PDGF-stimulated p70s6k activation (by 74.8 +/- 4.4% and 82.3 +/- 7.9% respectively).	Tetradecanoylphorbol Acetate	113-144	ribosomal protein S6 kinase B1	Bos taurus	206-212
9067639-5	1997	Downregulation of protein kinase C (PKC) alpha and epsilon isoforms by pretreatment of fibroblasts for 48 h with phorbol 12-myristate 13-acetate (PMA), markedly attenuated both thrombin and PDGF-stimulated p70s6k activation (by 74.8 +/- 4.4% and 82.3 +/- 7.9% respectively).	Tetradecanoylphorbol Acetate	146-149	ribosomal protein S6 kinase B1	Bos taurus	206-212
9022759-7	1997	These results indicated that cyclooxygenase-1 rather than cyclooxygenase-2 was predominantly induced depending on TPA.	Tetradecanoylphorbol Acetate	114-117	prostaglandin-endoperoxide synthase 1	Homo sapiens	29-45
9022759-7	1997	These results indicated that cyclooxygenase-1 rather than cyclooxygenase-2 was predominantly induced depending on TPA.	Tetradecanoylphorbol Acetate	114-117	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-74
9413940-3	1997	In addition, the PKC inhibitor Ro 31-8220 with predominant PKC-alpha isoform specificity almost completely inhibited PMA-induced up-regulation of p21WAF1 in HL-60 cells as well as in the myelomonocytic leukaemic U937 cells.	Tetradecanoylphorbol Acetate	117-120	protein kinase C alpha	Homo sapiens	17-20
9413940-3	1997	In addition, the PKC inhibitor Ro 31-8220 with predominant PKC-alpha isoform specificity almost completely inhibited PMA-induced up-regulation of p21WAF1 in HL-60 cells as well as in the myelomonocytic leukaemic U937 cells.	Tetradecanoylphorbol Acetate	117-120	protein kinase C alpha	Homo sapiens	59-68
9413940-4	1997	Pretreatment of HL-60 cells with Ro 31-8220 also inhibited PMA-induced activation of c-raf-1, a known PKC alpha target.	Tetradecanoylphorbol Acetate	59-62	protein kinase C alpha	Homo sapiens	102-105
9067616-2	1997	HEL cells grow in suspension in culture medium, but attach and spread on fibronectin when treated with 10 nM phorbol myristate acetate.	Tetradecanoylphorbol Acetate	109-134	fibronectin 1	Homo sapiens	73-84
9067628-7	1997	We report here that erythropoietin, inositolphosphate-glycan, and 12-O-tetradecanoyl-phorbol-13-acetate activated only the p44 form (erk-1) of MAP kinase and the Raf-1 protein.	Tetradecanoylphorbol Acetate	66-103	mitogen-activated protein kinase 3	Homo sapiens	133-138
9039082-7	1997	After protein kinase C activity was functionally depleted by treatment of cells with phorbol 12-myristate 13-acetate for 24 hours, the effect of endothelin-1 was abolished.	Tetradecanoylphorbol Acetate	85-116	endothelin 1	Rattus norvegicus	145-157
9088892-7	1997	Induction of fibronectin expression was also obtained using the PKC-activating phorbolester Phorbol-12-myristat-13-acetat (PMA) which mimicks glucose-induced PKC activation.	Tetradecanoylphorbol Acetate	123-126	fibronectin 1	Homo sapiens	13-24
8978751-2	1997	Subcellular fractionation and immunocytochemical studies demonstrated that an 8-min TPA treatment caused translocation of the alpha-subtype of protein kinase C (PKC) from the cytosol to the plasma membrane.	Tetradecanoylphorbol Acetate	84-87	protein kinase C alpha	Homo sapiens	161-164
9015756-6	1997	The expression of c-src, c-fms, and macrophage colony stimulating factor (M-CSF) was induced by TPA treatment; however, TPA-induced M-CSF gene transcription was attenuated by the subsequent addition of 1,25-(OH)2D3.	Tetradecanoylphorbol Acetate	96-99	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	18-23
9015756-6	1997	The expression of c-src, c-fms, and macrophage colony stimulating factor (M-CSF) was induced by TPA treatment; however, TPA-induced M-CSF gene transcription was attenuated by the subsequent addition of 1,25-(OH)2D3.	Tetradecanoylphorbol Acetate	120-123	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	18-23
8989665-5	1997	TPA-treated cells showed a decreased sensitivity to CNTF and a sevenfold decrease in levels of STAT3.	Tetradecanoylphorbol Acetate	0-3	signal transducer and activator of transcription 3	Homo sapiens	95-100
8996200-3	1997	Although TPA alone did not support colony formation, TPA in combination with IL-3 increased colony numbers from 1.5 to 2 times that formed with IL-3 and vehicle.	Tetradecanoylphorbol Acetate	53-56	interleukin 3	Mus musculus	144-148
8996200-6	1997	Because TPA enhanced IL-3-dependent colony formation derived from lineage-negative marrow cells obtained from mice that received 5-FU 2 days before, it is possible that it might act directly on primitive progenitors.	Tetradecanoylphorbol Acetate	8-11	interleukin 3	Mus musculus	21-25
8996200-8	1997	Calphostin C, a specific PKC inhibitor, and certain specific tyrosine kinase inhibitors, such as genistein and herbimycin A, abrogated the enhancing effects of TPA on IL-3-dependent colony formation.	Tetradecanoylphorbol Acetate	160-163	interleukin 3	Mus musculus	167-171
8996200-9	1997	These data suggest that TPA had a direct effect on the primitive progenitors and enhanced IL-3-dependent colony formation via activation of PKC and certain tyrosine kinases.	Tetradecanoylphorbol Acetate	24-27	interleukin 3	Mus musculus	90-94
9010457-0	1997	Modulation of E-cadherin expression in TPA-induced cell motility: well-differentiated human adenocarcinoma cells move as coherent sheets associated with phosphorylation of E-cadherin-catenin complex.	Tetradecanoylphorbol Acetate	39-42	cadherin 1	Homo sapiens	14-24
9010457-0	1997	Modulation of E-cadherin expression in TPA-induced cell motility: well-differentiated human adenocarcinoma cells move as coherent sheets associated with phosphorylation of E-cadherin-catenin complex.	Tetradecanoylphorbol Acetate	39-42	cadherin 1	Homo sapiens	172-182
9010457-6	1997	Apparently, however, E-cadherin was involved in the sheet formation of migrating cells because simultaneous or sequential treatment with TPA and HECD-1 inhibited sheet formation and caused scattering of migrating cells.	Tetradecanoylphorbol Acetate	137-140	cadherin 1	Homo sapiens	21-31
9010457-9	1997	We propose that cells are released from cell-cell adhesion only at the lower portion of the cells via phosphorylation of the E-cadherin-catenin complex when stimulated with TPA.	Tetradecanoylphorbol Acetate	173-176	cadherin 1	Homo sapiens	125-135
9218534-6	1997	Since the co-expression with a dominant negative c-Fos abolished the responsiveness to TPA, we conclude that activated transcription of the DRA gene depends on interactions between the X2 box and NF-X2, which contains c-Fos.	Tetradecanoylphorbol Acetate	87-90	solute carrier family 26 member 3	Homo sapiens	140-143
9011567-12	1997	The PMA-induced increase in HSP-72 protein peaked 8 h after treatment with PMA and returned to baseline levels at 72 h. This increase was blocked by a PKC inhibitor, staurosporine.	Tetradecanoylphorbol Acetate	4-7	heat shock protein family A (Hsp70) member 1A	Homo sapiens	28-34
8978751-8	1997	Selective down-regulation of PKC subtypes by prolonged exposure to phorbol 12,13-dibutyrate (100 nM) attenuated the TPA-induced enhancement of NA release and the translocation of MARCKS over an interval similar to that of down-regulation of PKC-alpha (but not -epsilon or -zeta).	Tetradecanoylphorbol Acetate	116-119	protein kinase C alpha	Homo sapiens	241-250
8978751-9	1997	Thus, we have demonstrated a strong correlation between the translocation of MARCKS and the enhancement of NA release from SH-SY5Y cells due to the TPA-induced activation of PKC-alpha.	Tetradecanoylphorbol Acetate	148-151	protein kinase C alpha	Homo sapiens	174-183
8978751-7	1997	The ability of TPA to enhance NA release and to cause the translocation and phosphorylation of MARCKS was inhibited by the PKC inhibitor Ro 31-8220 (10 microM).	Tetradecanoylphorbol Acetate	15-18	protein kinase C alpha	Homo sapiens	123-126
8978751-8	1997	Selective down-regulation of PKC subtypes by prolonged exposure to phorbol 12,13-dibutyrate (100 nM) attenuated the TPA-induced enhancement of NA release and the translocation of MARCKS over an interval similar to that of down-regulation of PKC-alpha (but not -epsilon or -zeta).	Tetradecanoylphorbol Acetate	116-119	protein kinase C alpha	Homo sapiens	29-32
9037533-5	1996	Down-regulation of PKC by overnight pre-treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) blocked only the phorbol ester-stimulated c-fos accumulation while no effect was observed in the carbachol-induced response.	Tetradecanoylphorbol Acetate	55-91	proline rich transmembrane protein 2	Homo sapiens	19-22
18472849-2	1997	Phorbol-12-myristate 13 acetate (PMA) caused a decrease in the levels of IL-6 in 14 out of 16 cultures and an increase in levels of sIL6R in all 15 cases.	Tetradecanoylphorbol Acetate	0-31	interleukin 6	Homo sapiens	73-77
18472849-2	1997	Phorbol-12-myristate 13 acetate (PMA) caused a decrease in the levels of IL-6 in 14 out of 16 cultures and an increase in levels of sIL6R in all 15 cases.	Tetradecanoylphorbol Acetate	33-36	interleukin 6	Homo sapiens	73-77
9037533-5	1996	Down-regulation of PKC by overnight pre-treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) blocked only the phorbol ester-stimulated c-fos accumulation while no effect was observed in the carbachol-induced response.	Tetradecanoylphorbol Acetate	93-96	proline rich transmembrane protein 2	Homo sapiens	19-22
9000129-4	1996	Here we present a characterization of the COM sequence: our results show that COM and COM-binding proteins (UEF, Urokinase Enhancer Factors) may play a structural role in the induction of the uPA enhancer by phorbol-myristate-acetate (TPA).	Tetradecanoylphorbol Acetate	208-233	plasminogen activator, urokinase	Homo sapiens	192-195
8955111-3	1996	A series of deletion and mutation analyses of the enhancer sequences defined the 45-base pair core region (DR-1 core) containing two short elements with similarity to AP-1 (12-O-tetradecanoylphorbol-13-acetate response element; TRE) and CREB/ATF (cyclic AMP response element; CRE) binding sites, both of which were necessary for full enhancer activity.	Tetradecanoylphorbol Acetate	173-209	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-171
9000129-4	1996	Here we present a characterization of the COM sequence: our results show that COM and COM-binding proteins (UEF, Urokinase Enhancer Factors) may play a structural role in the induction of the uPA enhancer by phorbol-myristate-acetate (TPA).	Tetradecanoylphorbol Acetate	235-238	plasminogen activator, urokinase	Homo sapiens	192-195
9003369-2	1996	The objective of the present work was to identify the PKC isoenzymes present in human placental trophoblasts and to compare their relative responses to acute and chronic phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	170-201	proline rich transmembrane protein 2	Homo sapiens	54-57
9003369-2	1996	The objective of the present work was to identify the PKC isoenzymes present in human placental trophoblasts and to compare their relative responses to acute and chronic phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	203-206	proline rich transmembrane protein 2	Homo sapiens	54-57
8943238-8	1996	Co-treatment with a tyrosine phosphatase inhibitor (sodium orthovanadate) and T-cell activation signals (phorbol 12-myristate 13-acetate plus ionomycin) prolonged JNK induction, followed by T-cell apoptosis.	Tetradecanoylphorbol Acetate	105-136	mitogen-activated protein kinase 8	Homo sapiens	163-166
8955209-4	1996	In contrast, PMA did not increase specific 125I-hC3a binding, and actually antagonized C3aR induction by IFN-gamma.	Tetradecanoylphorbol Acetate	13-16	interferon gamma	Homo sapiens	105-114
8943888-3	1996	In MDS patients, chemiluminescence stimulated with N-formyl-L-methionyl-L-leucil-L-phenylalanine (FMLP) and calcium ionophore A23187 was defective (17.2 +/- 13.7 v 44.3 +/- 16.6, P = 0.001; 42.2 +/- 21.3 v 82.0 +/- 23.6, P &lt; 0.05, respectively), but phorbol 12-myristate 13-acetate (PMA) chemiluminescence was normal (73.4 +/- 26.9 v 79.5 +/- 23.8, P = 0.52).	Tetradecanoylphorbol Acetate	253-284	formyl peptide receptor 1	Homo sapiens	98-102
8997261-8	1996	The TPA-induced increase in H82 cell attachment was likely mediated by activation of EC protein kinase C (PKC).	Tetradecanoylphorbol Acetate	4-7	protein kinase C alpha	Homo sapiens	106-109
8997261-9	1996	Pretreatment of the EC with PKC inhibitors effectively blocked the TPA-mediated increase in H82 cell attachment.	Tetradecanoylphorbol Acetate	67-70	protein kinase C alpha	Homo sapiens	28-31
8997261-10	1996	In addition, prolonged exposure of EC to TPA resulted in decreased expression of the PKC-alpha and PKC-epsilon isoforms.	Tetradecanoylphorbol Acetate	41-44	protein kinase C alpha	Homo sapiens	85-94
8943298-7	1996	In addition, we have also identified a 12-O-tetradecanoylphorbol-13-acetate-responsive element, which overlaps with a Pit-1/GHF-1 binding site.	Tetradecanoylphorbol Acetate	39-75	POU class 1 homeobox 1	Homo sapiens	118-129
8940130-4	1996	Our results indicated that while the down-regulation of novel PKC (nPKC) and conventional PKC (cPKC) by pretreatment of cells with 12-O-tetradecanoyl phorbol-13-acetate cannot block UVB-induced AP-1 activity, it can block 12-O-tetradecanoyl phorbol-13-acetate-induced AP-1 activity.	Tetradecanoylphorbol Acetate	131-168	proline rich transmembrane protein 2	Homo sapiens	62-65
8940130-4	1996	Our results indicated that while the down-regulation of novel PKC (nPKC) and conventional PKC (cPKC) by pretreatment of cells with 12-O-tetradecanoyl phorbol-13-acetate cannot block UVB-induced AP-1 activity, it can block 12-O-tetradecanoyl phorbol-13-acetate-induced AP-1 activity.	Tetradecanoylphorbol Acetate	131-168	proline rich transmembrane protein 2	Homo sapiens	68-71
8943888-3	1996	In MDS patients, chemiluminescence stimulated with N-formyl-L-methionyl-L-leucil-L-phenylalanine (FMLP) and calcium ionophore A23187 was defective (17.2 +/- 13.7 v 44.3 +/- 16.6, P = 0.001; 42.2 +/- 21.3 v 82.0 +/- 23.6, P &lt; 0.05, respectively), but phorbol 12-myristate 13-acetate (PMA) chemiluminescence was normal (73.4 +/- 26.9 v 79.5 +/- 23.8, P = 0.52).	Tetradecanoylphorbol Acetate	286-289	formyl peptide receptor 1	Homo sapiens	98-102
9025718-2	1996	In this study, human neuroblastoma SH-SY5Y cells have been treated with IGF-I and its potent analogue des(1-3)IGF-I alone or following preincubation with a differentiating agent such as 12-o-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	186-222	insulin like growth factor 1	Homo sapiens	72-77
8973627-4	1996	The CD4+CD7- subpopulation was found to secrete significantly higher levels of IL-5 compared with the CD4+CD7- subset upon stimulation with ionomycin/phorbol myristate acetate (PMA) plus anti-CD28 MoAbs.	Tetradecanoylphorbol Acetate	150-175	CD4 molecule	Homo sapiens	4-7
8973627-4	1996	The CD4+CD7- subpopulation was found to secrete significantly higher levels of IL-5 compared with the CD4+CD7- subset upon stimulation with ionomycin/phorbol myristate acetate (PMA) plus anti-CD28 MoAbs.	Tetradecanoylphorbol Acetate	177-180	CD4 molecule	Homo sapiens	4-7
8973628-6	1996	Hypoxia had an overall inhibitory effect on cytokine release except for PMA-induced IL-1 beta release, and hypoxia/reoxygenation had a significant up-regulating effect except for a further inhibition of fMLP-induced release of TNF-alpha.	Tetradecanoylphorbol Acetate	72-75	interleukin 1 beta	Homo sapiens	84-93
9010683-6	1996	Treatment of THP-1 cells with PMA and LPS caused the highest production of both IL-1 beta and IL-6 (&gt; 5ng/ml).	Tetradecanoylphorbol Acetate	30-33	interleukin 1 beta	Homo sapiens	80-89
9010683-6	1996	Treatment of THP-1 cells with PMA and LPS caused the highest production of both IL-1 beta and IL-6 (&gt; 5ng/ml).	Tetradecanoylphorbol Acetate	30-33	interleukin 6	Homo sapiens	94-98
8943424-10	1996	Quantitation of A23187 plus PMA-induced myosin light chain phosphorylation revealed that phosphorylation at PKC sites increased from zero to 0.35 mol/mol, was little changed at the monophosphorylated MLCK site (0.30 mol/mol), and increased from zero to 0.06 mol/mol at the diphosphorylated MLCK sites.	Tetradecanoylphorbol Acetate	28-31	myosin light chain kinase	Rattus norvegicus	200-204
8951422-5	1996	In contrast, 3-morpholinosydnonimine (SIN-1), a compound that rapidly generates peroxynitrite (ONOO-) from the released NO and O2-, slightly stimulated the PMA-induced respiratory burst.	Tetradecanoylphorbol Acetate	156-159	MAPK associated protein 1	Homo sapiens	38-43
8957112-4	1996	Phorbol ester (PMA) plus Ca-ionophore treatment efficiently induced CD40L.	Tetradecanoylphorbol Acetate	15-18	CD40 ligand	Homo sapiens	68-73
8977524-4	1996	The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	192-223	interferon gamma	Homo sapiens	69-85
8977524-4	1996	The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	192-223	interferon gamma	Homo sapiens	87-96
8977524-4	1996	The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	225-228	interferon gamma	Homo sapiens	69-85
8977524-4	1996	The tyrosine kinase inhibitor herbimycin inhibited the production of interferon-gamma (IFN-gamma) by THO-like clone, after stimulation with anti-CD3 monoclonal antibody alpha CD3-mAb) or with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	225-228	interferon gamma	Homo sapiens	87-96
8977524-7	1996	A23187, which synergizes with PMA in the induction of IL-4 and IFN-gamma, inhibited PMA-induced IL-10 production in a dose-dependent manner.	Tetradecanoylphorbol Acetate	30-33	interleukin 4	Homo sapiens	54-58
8977524-7	1996	A23187, which synergizes with PMA in the induction of IL-4 and IFN-gamma, inhibited PMA-induced IL-10 production in a dose-dependent manner.	Tetradecanoylphorbol Acetate	30-33	interferon gamma	Homo sapiens	63-72
8977524-7	1996	A23187, which synergizes with PMA in the induction of IL-4 and IFN-gamma, inhibited PMA-induced IL-10 production in a dose-dependent manner.	Tetradecanoylphorbol Acetate	84-87	interleukin 4	Homo sapiens	54-58
8977524-7	1996	A23187, which synergizes with PMA in the induction of IL-4 and IFN-gamma, inhibited PMA-induced IL-10 production in a dose-dependent manner.	Tetradecanoylphorbol Acetate	84-87	interferon gamma	Homo sapiens	63-72
8952703-9	1996	Activation of PKC with the phorbol ester phorbol 12-myristate 13-acetate (PMA) stimulated the secretion of ET-1 in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	41-72	endothelin 1	Rattus norvegicus	107-111
8952703-9	1996	Activation of PKC with the phorbol ester phorbol 12-myristate 13-acetate (PMA) stimulated the secretion of ET-1 in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	74-77	endothelin 1	Rattus norvegicus	107-111
8943424-10	1996	Quantitation of A23187 plus PMA-induced myosin light chain phosphorylation revealed that phosphorylation at PKC sites increased from zero to 0.35 mol/mol, was little changed at the monophosphorylated MLCK site (0.30 mol/mol), and increased from zero to 0.06 mol/mol at the diphosphorylated MLCK sites.	Tetradecanoylphorbol Acetate	28-31	myosin light chain kinase	Rattus norvegicus	290-294
9004163-0	1996	Phorbol myristate acetate-induced hypertrophy of neonatal rat cardiac myocytes is associated with decreased sarcoplasmic reticulum Ca2+ ATPase (SERCA2) gene expression and calcium reuptake.	Tetradecanoylphorbol Acetate	0-25	carbonic anhydrase 2	Rattus norvegicus	131-142
9181608-4	1996	Long-term cultures of normal human keratiocytes were prepared in a serum-free medium, and stimulated with 1 microgram/ml of phorbol 12-myristate 13-acetate (TPA) and UCA or UVB-UCA (10-100 micrograms/ml).	Tetradecanoylphorbol Acetate	124-155	plasminogen activator, tissue type	Homo sapiens	157-160
9049971-0	1996	Phorbol ester PMA induces expression of the thrombopoietin receptor MPL in leukemia cells.	Tetradecanoylphorbol Acetate	14-17	thrombopoietin	Homo sapiens	44-58
9049971-0	1996	Phorbol ester PMA induces expression of the thrombopoietin receptor MPL in leukemia cells.	Tetradecanoylphorbol Acetate	14-17	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	68-71
8939883-2	1996	Growth inhibition of the Calu-1 lung carcinoma cells induced with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent activator of protein kinase C, is associated with G2/M arrest and induction of expression of a novel, faster-migrating form of p21(WAF1/CIP1/SDI1) (p21) protein, an inhibitor of cyclin-dependent kinases.	Tetradecanoylphorbol Acetate	122-125	cyclin dependent kinase inhibitor 1A	Homo sapiens	264-277
8939883-2	1996	Growth inhibition of the Calu-1 lung carcinoma cells induced with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent activator of protein kinase C, is associated with G2/M arrest and induction of expression of a novel, faster-migrating form of p21(WAF1/CIP1/SDI1) (p21) protein, an inhibitor of cyclin-dependent kinases.	Tetradecanoylphorbol Acetate	122-125	cyclin dependent kinase inhibitor 1A	Homo sapiens	278-282
8939883-2	1996	Growth inhibition of the Calu-1 lung carcinoma cells induced with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent activator of protein kinase C, is associated with G2/M arrest and induction of expression of a novel, faster-migrating form of p21(WAF1/CIP1/SDI1) (p21) protein, an inhibitor of cyclin-dependent kinases.	Tetradecanoylphorbol Acetate	122-125	cyclin dependent kinase inhibitor 1A	Homo sapiens	264-267
8939883-3	1996	This faster-migrating p21 protein was also expressed in TPA-treated A549 lung carcinoma cells which also exhibited G2/M arrest but not in TPA-treated U937 leukemia cells, which only expressed a slower-migrating form of p21 protein.	Tetradecanoylphorbol Acetate	56-59	cyclin dependent kinase inhibitor 1A	Homo sapiens	22-25
8939949-3	1996	While COX-1 expression is largely constitutive, COX-2 is highly regulated by cytokines, growth factors, and tumor promoters, such as the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	171-202	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53
8939883-3	1996	This faster-migrating p21 protein was also expressed in TPA-treated A549 lung carcinoma cells which also exhibited G2/M arrest but not in TPA-treated U937 leukemia cells, which only expressed a slower-migrating form of p21 protein.	Tetradecanoylphorbol Acetate	56-59	cyclin dependent kinase inhibitor 1A	Homo sapiens	219-222
8939883-3	1996	This faster-migrating p21 protein was also expressed in TPA-treated A549 lung carcinoma cells which also exhibited G2/M arrest but not in TPA-treated U937 leukemia cells, which only expressed a slower-migrating form of p21 protein.	Tetradecanoylphorbol Acetate	138-141	cyclin dependent kinase inhibitor 1A	Homo sapiens	22-25
8910539-1	1996	Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	92-123	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	15-30
8954139-6	1996	The elevation of [Ca2+]i induced by thrombin, STA2 or PGE2 was significantly suppressed by pretreatment of the cells with TPA (100 nM) as well as cAMP mimetics such as dibutyryl cAMP (5 mM), forskolin (5 microM) and iloprost (1 microM).	Tetradecanoylphorbol Acetate	122-125	coagulation factor II, thrombin	Homo sapiens	36-44
8971787-2	1996	Incubation of the cells for 24 h with A beta(25-35) as well as with A beta(1-42) resulted in an enhanced production of reactive oxygen radicals (ROI) in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	165-196	amyloid beta precursor protein	Homo sapiens	38-44
8971787-2	1996	Incubation of the cells for 24 h with A beta(25-35) as well as with A beta(1-42) resulted in an enhanced production of reactive oxygen radicals (ROI) in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	198-201	amyloid beta precursor protein	Homo sapiens	38-44
8910543-4	1996	These effects were blocked by EGTA or by protein kinase C inhibitors (RO31-8220; GF109203X) and mimicked by ionomycin or phorbol 12-myristate 13-acetate, in the case of pp125(FAK), or their combination in the case of PYK2/CAKbeta.	Tetradecanoylphorbol Acetate	121-152	protein tyrosine kinase 2 beta	Rattus norvegicus	217-221
8910539-1	1996	Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	92-123	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	32-35
8910543-4	1996	These effects were blocked by EGTA or by protein kinase C inhibitors (RO31-8220; GF109203X) and mimicked by ionomycin or phorbol 12-myristate 13-acetate, in the case of pp125(FAK), or their combination in the case of PYK2/CAKbeta.	Tetradecanoylphorbol Acetate	121-152	protein tyrosine kinase 2 beta	Rattus norvegicus	222-229
8910539-1	1996	Stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) by phorbol 12-myristate 13-acetate (PMA) has been shown to be mediated by the alpha- and betaI-isoforms of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	92-123	protein kinase C alpha	Homo sapiens	214-217
8910539-4	1996	Stable expression of PKC-alpha in MCF-7 cells, which was accompanied by increased levels of the betaI- and theta-isoforms as well, greatly enhanced both PMA-induced PLD-mediated formation of phosphatidylethanol (approximately 5-fold) and the hydrolysis of PtdEtn (2.5-2.9-fold) and PtdCho (5.5-7.2-fold).	Tetradecanoylphorbol Acetate	153-156	protein kinase C alpha	Homo sapiens	21-30
8910539-4	1996	Stable expression of PKC-alpha in MCF-7 cells, which was accompanied by increased levels of the betaI- and theta-isoforms as well, greatly enhanced both PMA-induced PLD-mediated formation of phosphatidylethanol (approximately 5-fold) and the hydrolysis of PtdEtn (2.5-2.9-fold) and PtdCho (5.5-7.2-fold).	Tetradecanoylphorbol Acetate	153-156	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	165-168
8910539-5	1996	The effects of PMA on the hydrolysis of PtdEtn (and PtdCho) in MCF-7/PKC-alpha cells were significantly inhibited by 0.5-3 microM concentrations of Go 6976, a selective inhibitor of the conventional PKC subfamily.	Tetradecanoylphorbol Acetate	15-18	protein kinase C alpha	Homo sapiens	69-78
8910539-5	1996	The effects of PMA on the hydrolysis of PtdEtn (and PtdCho) in MCF-7/PKC-alpha cells were significantly inhibited by 0.5-3 microM concentrations of Go 6976, a selective inhibitor of the conventional PKC subfamily.	Tetradecanoylphorbol Acetate	15-18	protein kinase C alpha	Homo sapiens	69-72
8910539-6	1996	Stable expression of PKC-alpha in R6 fibroblasts enhanced, at a shorter (10 min) incubation time, the effects of PMA on the hydrolysis of both PtdEtn and, to a lesser extent, PtdCho.	Tetradecanoylphorbol Acetate	113-116	protein kinase C alpha	Homo sapiens	21-30
8945961-2	1996	Of three compounds known to stimulate t-PA synthesis in cultured human endothelial cells, i.e., retinoic acid, the protein kinase C activator 4 beta-phorbol 12-myristate 13-acetate (PMA), and sodium butyrate, only butyrate (1 mM) caused about a threefold increase in t-PA synthesis and mRNA expression in HMC after 24 h of incubation, without markedly affecting PAI-1 synthesis.	Tetradecanoylphorbol Acetate	144-180	plasminogen activator, tissue type	Homo sapiens	38-42
8941662-9	1996	Phorbol 12-myristate 13-acetate, calcium ionophore, and cAMP analogues only increased ERK activity but had no significant effects on JNK or p38.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 1	Homo sapiens	86-89
8972728-6	1996	Elevation of membrane PKC levels by 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment had no effect on cell survival after irradiation, while treatment with EGF during and after irradiation augmented cell survival.	Tetradecanoylphorbol Acetate	36-72	protein kinase C alpha	Homo sapiens	22-25
8972728-6	1996	Elevation of membrane PKC levels by 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment had no effect on cell survival after irradiation, while treatment with EGF during and after irradiation augmented cell survival.	Tetradecanoylphorbol Acetate	74-77	protein kinase C alpha	Homo sapiens	22-25
8945961-2	1996	Of three compounds known to stimulate t-PA synthesis in cultured human endothelial cells, i.e., retinoic acid, the protein kinase C activator 4 beta-phorbol 12-myristate 13-acetate (PMA), and sodium butyrate, only butyrate (1 mM) caused about a threefold increase in t-PA synthesis and mRNA expression in HMC after 24 h of incubation, without markedly affecting PAI-1 synthesis.	Tetradecanoylphorbol Acetate	182-185	plasminogen activator, tissue type	Homo sapiens	38-42
8945961-3	1996	PMA (10 nM) induced a threefold increase in urokinase-type plasminogen activator (u-PA) mRNA, but u-PA antigen levels in the HMC conditioned media remained below the detection level (0.5 ng/ml), possibly as a result of rapid uptake and degradation by the u-PA receptor.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase	Homo sapiens	44-80
8945961-3	1996	PMA (10 nM) induced a threefold increase in urokinase-type plasminogen activator (u-PA) mRNA, but u-PA antigen levels in the HMC conditioned media remained below the detection level (0.5 ng/ml), possibly as a result of rapid uptake and degradation by the u-PA receptor.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase	Homo sapiens	82-86
8912844-4	1996	Estrogen-dependent MCF-7 cells exhibited a relatively high expression of COX-1; COX-2 was barely detectable but was transiently induced by treatment with TPA (10 nM).	Tetradecanoylphorbol Acetate	154-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
8950029-4	1996	PMA, but not Ara-C or ceramides, activated ERK MAPKS, in Jurkat and EL4.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	43-46
8912844-6	1996	This high COX-2 expression applied to both the protein and mRNA and increased further over a relatively long period of time in the presence of TPA.	Tetradecanoylphorbol Acetate	143-146	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-15
8968046-5	1996	Based on our previous evidence that tumour necrosis factor-alpha (TNF-alpha) acts as an endogenous tumour promoter on BALB/3T3 cells initiated with 3-methylcholanthrene, we found that morphine dose-dependently inhibited TnF-alpha release from KATO III cells (IC50, 5.6 mM) and also from BALB/3T3 cells (IC50, 1.3 mM) induced by okadaic acid, one of the non-TPA type tumour promoters.	Tetradecanoylphorbol Acetate	357-360	tumor necrosis factor	Mus musculus	66-75
9024988-6	1996	THP-1 cells were primed with a phorbol ester (PMA) for 24 h, then they were cultured for 4 and 24 h in the presence of inactivated culture supernatant of dengue infected AP61 cells or control preparations.	Tetradecanoylphorbol Acetate	46-49	GLI family zinc finger 2	Homo sapiens	0-5
8906745-4	1996	Our work demonstrates that: (1) resting B cells from mice containing the Yaa allele hyperproliferated compared to that seen with B cells from mice lacking the Yaa allele, (2) this hyperproliferation occurred whether cells were stimulated with phorbol myristate acetate/ionomycin, LPS, anti-IgM, or CD40L cross-linking, (3) this hyperproliferation is specific to B and not T cells.	Tetradecanoylphorbol Acetate	243-268	toll-like receptor 4	Mus musculus	280-283
9024981-1	1996	The effects of phorbol 12-myristate 13-acetate (PMA) on the activities of phospholipase D (PLD3), mitogen-activated protein kinase (ERK), and c-Jun N-terminal kinase (JNK) were studied in Jurkat, a human T cell line, and EL4, a murine T-cell line.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 8	Homo sapiens	142-165
8938544-8	1996	The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1.	Tetradecanoylphorbol Acetate	109-140	interferon gamma	Homo sapiens	314-360
8890188-5	1996	Furthermore, the toxin B pretreatment also suppressed PLD activation induced by 4beta-phorbol 12-myristate 13-acetate in HL60 cell lysates.	Tetradecanoylphorbol Acetate	80-117	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	54-57
8915773-9	1996	Phorbol 12-myristate 13-acetate (PMA) also stimulated PLD activity in human bone cells.	Tetradecanoylphorbol Acetate	0-31	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	54-57
8915773-9	1996	Phorbol 12-myristate 13-acetate (PMA) also stimulated PLD activity in human bone cells.	Tetradecanoylphorbol Acetate	33-36	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	54-57
8915773-11	1996	Acute pretreatment of cells with PMA reduced concomitantly the amounts of PKC alpha, but not of PKC epsilon, and the subsequent activation of PLD elicited by PKC activators.	Tetradecanoylphorbol Acetate	33-36	protein kinase C alpha	Homo sapiens	74-83
8915773-11	1996	Acute pretreatment of cells with PMA reduced concomitantly the amounts of PKC alpha, but not of PKC epsilon, and the subsequent activation of PLD elicited by PKC activators.	Tetradecanoylphorbol Acetate	33-36	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	142-145
8915773-11	1996	Acute pretreatment of cells with PMA reduced concomitantly the amounts of PKC alpha, but not of PKC epsilon, and the subsequent activation of PLD elicited by PKC activators.	Tetradecanoylphorbol Acetate	33-36	protein kinase C alpha	Homo sapiens	74-77
8915773-14	1996	Moreover, PMA and NaF showed a supraadditive effect on PLD activation in Saos-2 cells.	Tetradecanoylphorbol Acetate	10-13	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	55-58
8863492-7	1996	In contrast to reports that the VIP-CRE imparts 12-O-tetradecanoylphorbol 13-acetate (phorbol 12-myristate 13-acetate; PMA) responsiveness to heterologous promoters, PMA stimulation in SK-N-SH cells was independent of an intact VIP-CRE but dependent on a region between -2.5 kb and the VIP-CRE.	Tetradecanoylphorbol Acetate	48-84	vasoactive intestinal peptide	Homo sapiens	32-35
8863492-7	1996	In contrast to reports that the VIP-CRE imparts 12-O-tetradecanoylphorbol 13-acetate (phorbol 12-myristate 13-acetate; PMA) responsiveness to heterologous promoters, PMA stimulation in SK-N-SH cells was independent of an intact VIP-CRE but dependent on a region between -2.5 kb and the VIP-CRE.	Tetradecanoylphorbol Acetate	86-117	vasoactive intestinal peptide	Homo sapiens	32-35
8930166-5	1996	Our pharmacological study suggests that, in neutrophil-like HL-60 cells, the signaling pathways leading to PMA-stimulated O2- generation appear to involve PKC, MAPK, phospholipase A2, arachidonic acid, PSP 1 and 2a and PTP.	Tetradecanoylphorbol Acetate	107-110	phospholipase A2 group IB	Homo sapiens	166-182
8950233-2	1996	We have shown previously that phorbol 12-myristate 13-acetate (PMA) induces the Dami human megakaryocytic cell line to become polyploid and to express platelet-specific proteins, including von Willebrand factor (vWF) and glycoprotein Ib (GpIb).	Tetradecanoylphorbol Acetate	30-61	von Willebrand factor	Homo sapiens	189-210
8950233-2	1996	We have shown previously that phorbol 12-myristate 13-acetate (PMA) induces the Dami human megakaryocytic cell line to become polyploid and to express platelet-specific proteins, including von Willebrand factor (vWF) and glycoprotein Ib (GpIb).	Tetradecanoylphorbol Acetate	30-61	von Willebrand factor	Homo sapiens	212-215
8950233-2	1996	We have shown previously that phorbol 12-myristate 13-acetate (PMA) induces the Dami human megakaryocytic cell line to become polyploid and to express platelet-specific proteins, including von Willebrand factor (vWF) and glycoprotein Ib (GpIb).	Tetradecanoylphorbol Acetate	63-66	von Willebrand factor	Homo sapiens	189-210
8950233-2	1996	We have shown previously that phorbol 12-myristate 13-acetate (PMA) induces the Dami human megakaryocytic cell line to become polyploid and to express platelet-specific proteins, including von Willebrand factor (vWF) and glycoprotein Ib (GpIb).	Tetradecanoylphorbol Acetate	63-66	von Willebrand factor	Homo sapiens	212-215
8950233-8	1996	We also examined dPPA and PMA for their ability to activate and to downregulate expression of different PKC isoforms.	Tetradecanoylphorbol Acetate	26-29	protein kinase C alpha	Homo sapiens	104-107
8950233-9	1996	Fifteen-minute treatment with PMA resulted in the translocation of PKC isoforms alpha, epsilon, and theta from the cytosolic to the membrane fraction; twenty-four hour treatment resulted in the downregulation of these isoforms.	Tetradecanoylphorbol Acetate	30-33	protein kinase C alpha	Homo sapiens	67-105
8930166-2	1996	The following agents inhibited phorbol 12-myristate 13-acetate-stimulated O2- generation significantly in the all-trans retinoic acid-treated HL-60 cells (expressed as percentage of control, P &lt; .05): 1) PKC inhibitors: staurosporine (100 nM, 3 +/- 1%); Ro 31-8220 (1 microM, 3 +/- 2%); sphingosine (100 microM, 15 +/- 7%); 2) PSP 1 and 2a inhibitors, okadaic acid (10 microM, 35 +/- 1%); calyculin A (10 microM, 73 +/- 1%); 3) MAPK inhibitor: SB-203580 (100 microM, 62 +/- 1%); 4) PTP inhibitors: phenylarsine oxide (1 microM, 12 +/- 9%); diamide (1 mM, 21 +/- 11%); and 5) secretory phospholipase A2 inhibitors: manoalide (1 microM, 24 +/- 10%); scalaradial (1 microM, 11 +/- 4%).	Tetradecanoylphorbol Acetate	31-62	phospholipase A2 group IB	Homo sapiens	588-604
8887624-4	1996	Cotransfection of RasN17, a dominant negative mutant of Ha-Ras, attenuated the shear-activated JNK and luciferase reporters driven by 12-O-tetradecanoylphorbol-13-acetate-responsive elements.	Tetradecanoylphorbol Acetate	134-170	mitogen-activated protein kinase 8	Homo sapiens	95-98
8948021-6	1996	Proper crosslinking of TCR together with CD4, CD8, or LFA-1 inhibits the death, and its inhibitory activity is mimicked by proper combinations of ionomycin, a calcium ionophore, and phorbol myristate acetate (PMA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	182-207	CD4 molecule	Homo sapiens	41-44
8948503-8	1996	Phorbol-myristate acetate (PMA) induced PGHS-2 activity and mRNA and neither PMA-induced, nor constitutive PGHS-2 expression was suppressed by corticosteroids.	Tetradecanoylphorbol Acetate	0-25	prostaglandin-endoperoxide synthase 2	Homo sapiens	40-46
8948503-8	1996	Phorbol-myristate acetate (PMA) induced PGHS-2 activity and mRNA and neither PMA-induced, nor constitutive PGHS-2 expression was suppressed by corticosteroids.	Tetradecanoylphorbol Acetate	27-30	prostaglandin-endoperoxide synthase 2	Homo sapiens	40-46
8947596-6	1996	However, the T cells of B10 mice produced high levels of IL-2 and IL-4 when stimulated by phorbol myristate acetate (PMA) and Ca2+ ionophore, proving the existence of a functionally intact signal transduction pathway downstream of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	90-115	granzyme C	Mus musculus	24-27
8947596-6	1996	However, the T cells of B10 mice produced high levels of IL-2 and IL-4 when stimulated by phorbol myristate acetate (PMA) and Ca2+ ionophore, proving the existence of a functionally intact signal transduction pathway downstream of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	117-120	granzyme C	Mus musculus	24-27
8948021-8	1996	Transient stimulation with the combinations of ionomycin and PMA induces differentiation and commitment of isolated DP thymocytes to the CD4 or CD8 T cell lineage in suspension cultures.	Tetradecanoylphorbol Acetate	61-64	CD4 molecule	Homo sapiens	137-140
8849450-2	1996	Treatment of human cell lines with soluble monomeric gp120 at 37 degrees C induced an association between the surface CD4-gp120 complex and a 45-kilodalton protein, which can be down-modulated by the phorbol ester phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	214-245	CD4 molecule	Homo sapiens	118-121
8900312-9	1996	Following stimulation with ionomycin and PMA, high doses (10(-6) M) of Dex inhibited the activity of the IL-2 promoter (approximately 50% inhibition).	Tetradecanoylphorbol Acetate	41-44	interleukin 2	Homo sapiens	105-109
8824244-5	1996	Phosphorylation of Galpha12 and Galpha13 could be mimicked by phorbol 12-myristate 13-acetate, and thrombin-induced phosphorylation was inhibited by the protein kinase C inhibitor calphostin C indicating an involvement of protein kinase C in Galpha12/13 phosphorylation induced by thrombin in human platelets.	Tetradecanoylphorbol Acetate	62-93	G protein subunit alpha 12	Homo sapiens	19-27
8824244-7	1996	Among the protein knase C isoforms tested, protein kinase C beta, delta, and epsilon were most effective in promoting phosphorylation of Galpha12 and Galpha13 in a phorbol 12-myristate 13-acetate-dependent manner.	Tetradecanoylphorbol Acetate	164-195	G protein subunit alpha 12	Homo sapiens	137-145
8824276-3	1996	In the present study, we examined the effects of phorbol 12-myristate 13-acetate, a potent PKC activator, on the ligand-induced transcriptional activation of the CYP1A1 gene and cellular function of the AhR in human HepG2 101L cells.	Tetradecanoylphorbol Acetate	49-80	proline rich transmembrane protein 2	Homo sapiens	91-94
8824249-2	1996	Plasminogen activator inhibitor type 2 (PAI-2) mRNA and antigen levels are synergistically induced in HT-1080 fibrosarcoma cells when treated with a combination of tumor necrosis factor (TNF) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	229-232	tumor necrosis factor	Homo sapiens	164-185
8830674-3	1996	We show here that bax protein also declined with a time course similar to the downregulation of bcl-2 following treatment of HL60 with phorbol myristate acetate (PMA), dimethyl sulphoxide (DMSO) or retinoic acid (RA).	Tetradecanoylphorbol Acetate	135-160	BCL2 associated X, apoptosis regulator	Homo sapiens	18-21
8912814-1	1996	The protein kinase C (PKC) signal transduction pathway is the prototype of a growth factor-responsive intracellular signaling system, which is activated by various cytokines, growth factors and tumor promoters, such as the phorbol ester 12-O-tetradecanoyl-phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	237-271	protein kinase C alpha	Homo sapiens	22-25
8912814-1	1996	The protein kinase C (PKC) signal transduction pathway is the prototype of a growth factor-responsive intracellular signaling system, which is activated by various cytokines, growth factors and tumor promoters, such as the phorbol ester 12-O-tetradecanoyl-phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	273-276	protein kinase C alpha	Homo sapiens	22-25
8912814-5	1996	The moderately differentiated endometrial HEC-1-B adenocarcinoma cell line showed a marked increase in proliferative activity and a profound morphological change in response to TPA.	Tetradecanoylphorbol Acetate	177-180	NDC80 kinetochore complex component	Homo sapiens	42-47
8912814-10	1996	Our data demonstrate that the proliferative response to TPA correlates with the expression levels of the majority of PKC isoforms in these cells.	Tetradecanoylphorbol Acetate	56-59	protein kinase C alpha	Homo sapiens	117-120
8830674-3	1996	We show here that bax protein also declined with a time course similar to the downregulation of bcl-2 following treatment of HL60 with phorbol myristate acetate (PMA), dimethyl sulphoxide (DMSO) or retinoic acid (RA).	Tetradecanoylphorbol Acetate	135-160	BCL2 apoptosis regulator	Homo sapiens	96-101
8830674-3	1996	We show here that bax protein also declined with a time course similar to the downregulation of bcl-2 following treatment of HL60 with phorbol myristate acetate (PMA), dimethyl sulphoxide (DMSO) or retinoic acid (RA).	Tetradecanoylphorbol Acetate	162-165	BCL2 associated X, apoptosis regulator	Homo sapiens	18-21
8908154-5	1996	Lovastatin (5-15 microM) caused a significant dose-related reduction in steady state levels of type-I SCR mRNA in phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells.	Tetradecanoylphorbol Acetate	114-145	GLI family zinc finger 2	Homo sapiens	160-165
8908154-5	1996	Lovastatin (5-15 microM) caused a significant dose-related reduction in steady state levels of type-I SCR mRNA in phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells.	Tetradecanoylphorbol Acetate	147-150	GLI family zinc finger 2	Homo sapiens	160-165
8810290-4	1996	Upon exposure to 8-bromo-cyclic AMP (cAMP, 0.1 mM), phorbol 12-myristate 13-acetate (PMA, 10 nM), terbutaline (0.1 mM), or ATP (1 mM), the binding of SP-A increased 1.5-2-fold.	Tetradecanoylphorbol Acetate	52-83	surfactant protein A1	Rattus norvegicus	150-154
8810290-6	1996	A time course of the stimulation of SP-A binding due to secretagogues showed that both cAMP and PMA increased SP-A binding by 2-fold after 20 min.	Tetradecanoylphorbol Acetate	96-99	surfactant protein A1	Rattus norvegicus	36-40
8810290-6	1996	A time course of the stimulation of SP-A binding due to secretagogues showed that both cAMP and PMA increased SP-A binding by 2-fold after 20 min.	Tetradecanoylphorbol Acetate	96-99	surfactant protein A1	Rattus norvegicus	110-114
8810290-10	1996	Type II cells pretreated with PMA responded to subsequent treatment with cAMP by increasing SP-A binding, while these cells were refractory to subsequent treatment with PMA.	Tetradecanoylphorbol Acetate	30-33	surfactant protein A1	Rattus norvegicus	92-96
8830674-3	1996	We show here that bax protein also declined with a time course similar to the downregulation of bcl-2 following treatment of HL60 with phorbol myristate acetate (PMA), dimethyl sulphoxide (DMSO) or retinoic acid (RA).	Tetradecanoylphorbol Acetate	162-165	BCL2 apoptosis regulator	Homo sapiens	96-101
8798752-2	1996	In intact HL-60 cells, phorbol myristate acetate (PMA) activated PLD as measured by [3H]palmitate-labeled phosphatidylcholine conversion to phosphatidylethanol in the presence of 2% ethanol.	Tetradecanoylphorbol Acetate	23-48	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	65-68
8798752-5	1996	Although ceramide inhibited PMA-induced activation of PLD, it did not inhibit translocation of protein kinase C (PKC) to the membrane in response to PMA.	Tetradecanoylphorbol Acetate	28-31	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	54-57
8798752-2	1996	In intact HL-60 cells, phorbol myristate acetate (PMA) activated PLD as measured by [3H]palmitate-labeled phosphatidylcholine conversion to phosphatidylethanol in the presence of 2% ethanol.	Tetradecanoylphorbol Acetate	50-53	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	65-68
8879181-5	1996	LMC demonstrated upregulation of IL-13 mRNA expression following treatment with A23187 (n = 4), with maximal upregulation by 3 h; anti-IgE or phorbol myristate acetate (PMA) also led to increased IL-13 mRNA expression.	Tetradecanoylphorbol Acetate	142-167	interleukin 13	Homo sapiens	33-38
8879181-5	1996	LMC demonstrated upregulation of IL-13 mRNA expression following treatment with A23187 (n = 4), with maximal upregulation by 3 h; anti-IgE or phorbol myristate acetate (PMA) also led to increased IL-13 mRNA expression.	Tetradecanoylphorbol Acetate	142-167	interleukin 13	Homo sapiens	196-201
8902191-4	1996	Translocation of PKC from the cytosolic to the membranous compartment upon stimulation with PMA was perturbed in ML-4 cells.	Tetradecanoylphorbol Acetate	92-95	proline rich transmembrane protein 2	Homo sapiens	17-20
8902191-4	1996	Translocation of PKC from the cytosolic to the membranous compartment upon stimulation with PMA was perturbed in ML-4 cells.	Tetradecanoylphorbol Acetate	92-95	mucolipin TRP cation channel 1	Homo sapiens	113-117
8870667-0	1996	Post-transcriptional regulation of H-ferritin gene expression in human monocytic THP-1 cells by protein kinase C. The mRNA coding for H-ferritin was highly induced in human monocytic THP-1 cells following treatment with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	220-251	GLI family zinc finger 2	Homo sapiens	81-86
8870699-7	1996	Activation of PPD-specific TCL from patients with calcium ionophore A23187 plus phorbol myristate acetate resulted in much higher IFN-gamma production than in TCL established from healthy controls, indicating that the low production of IFN-gamma by PPD-specific T cells from atopic patients is not due to an intrinsic T cell defect but to some regulatory mechanisms.	Tetradecanoylphorbol Acetate	80-105	interferon gamma	Homo sapiens	130-139
8870667-0	1996	Post-transcriptional regulation of H-ferritin gene expression in human monocytic THP-1 cells by protein kinase C. The mRNA coding for H-ferritin was highly induced in human monocytic THP-1 cells following treatment with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	220-251	GLI family zinc finger 2	Homo sapiens	183-188
9102146-9	1996	In addition, a dose-dependent loss of cell surface thrombin receptor is induced by phorbol-12-myristate-13-acetate (PMA), suggesting that thrombin receptor undergoes heterologous internalization in response to PMA.	Tetradecanoylphorbol Acetate	83-114	coagulation factor II, thrombin	Homo sapiens	51-59
9102146-9	1996	In addition, a dose-dependent loss of cell surface thrombin receptor is induced by phorbol-12-myristate-13-acetate (PMA), suggesting that thrombin receptor undergoes heterologous internalization in response to PMA.	Tetradecanoylphorbol Acetate	83-114	coagulation factor II, thrombin	Homo sapiens	138-146
9102146-9	1996	In addition, a dose-dependent loss of cell surface thrombin receptor is induced by phorbol-12-myristate-13-acetate (PMA), suggesting that thrombin receptor undergoes heterologous internalization in response to PMA.	Tetradecanoylphorbol Acetate	116-119	coagulation factor II, thrombin	Homo sapiens	51-59
9102146-9	1996	In addition, a dose-dependent loss of cell surface thrombin receptor is induced by phorbol-12-myristate-13-acetate (PMA), suggesting that thrombin receptor undergoes heterologous internalization in response to PMA.	Tetradecanoylphorbol Acetate	116-119	coagulation factor II, thrombin	Homo sapiens	138-146
8808644-3	1996	Similarly to anti-IgE, two activators of protein kinase C, tetradecanoylphorbol acetate (TPA) and bryostatin 1, significantly inhibited the substance P-induced response.	Tetradecanoylphorbol Acetate	59-87	tachykinin precursor 1	Homo sapiens	140-151
8913498-1	1996	In this report, we have investigated the effect of interleukin 1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA), potent stimulators of proMMPs and TIMP-1 production, on the translation of proMMP-3 and TIMP-1 mRNAs.	Tetradecanoylphorbol Acetate	88-124	TIMP metallopeptidase inhibitor 1	Homo sapiens	166-172
8913498-1	1996	In this report, we have investigated the effect of interleukin 1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA), potent stimulators of proMMPs and TIMP-1 production, on the translation of proMMP-3 and TIMP-1 mRNAs.	Tetradecanoylphorbol Acetate	88-124	TIMP metallopeptidase inhibitor 1	Homo sapiens	220-226
8913498-1	1996	In this report, we have investigated the effect of interleukin 1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA), potent stimulators of proMMPs and TIMP-1 production, on the translation of proMMP-3 and TIMP-1 mRNAs.	Tetradecanoylphorbol Acetate	126-129	TIMP metallopeptidase inhibitor 1	Homo sapiens	166-172
8913498-2	1996	When human uterine cervical fibroblasts were treated with IL-1 alpha or TPA for 2h, their translations were not augmented, whereas the steady-state levels of proMMP-3 and TIMP-1 mRNAs in the cells treated with these stimuli for 24 h were increased 13.3- and 1.3-fold by IL-1 alpha and 52.5- and 5.7-fold by TPA, respectively.	Tetradecanoylphorbol Acetate	72-75	TIMP metallopeptidase inhibitor 1	Homo sapiens	171-177
8904648-13	1996	Furthermore, PMA diminished histamine evoked Ca2+ release (50 +/- 6%) and blocked Ca2+ entry completely.	Tetradecanoylphorbol Acetate	13-16	carbonic anhydrase 2	Mesocricetus auratus	45-48
8904648-13	1996	Furthermore, PMA diminished histamine evoked Ca2+ release (50 +/- 6%) and blocked Ca2+ entry completely.	Tetradecanoylphorbol Acetate	13-16	carbonic anhydrase 2	Mesocricetus auratus	82-85
8904830-2	1996	All the compounds showed inducer-specific and bidirectional regulation of TNF-alpha production, i.e., they enhanced 12-O-tetradecanoylphorbol-13-acetate-induced TNF-alpha production, while they inhibited okadaic acid-induced one.	Tetradecanoylphorbol Acetate	116-152	tumor necrosis factor	Homo sapiens	74-83
8904830-2	1996	All the compounds showed inducer-specific and bidirectional regulation of TNF-alpha production, i.e., they enhanced 12-O-tetradecanoylphorbol-13-acetate-induced TNF-alpha production, while they inhibited okadaic acid-induced one.	Tetradecanoylphorbol Acetate	116-152	tumor necrosis factor	Homo sapiens	161-170
8808644-3	1996	Similarly to anti-IgE, two activators of protein kinase C, tetradecanoylphorbol acetate (TPA) and bryostatin 1, significantly inhibited the substance P-induced response.	Tetradecanoylphorbol Acetate	89-92	tachykinin precursor 1	Homo sapiens	140-151
8870699-7	1996	Activation of PPD-specific TCL from patients with calcium ionophore A23187 plus phorbol myristate acetate resulted in much higher IFN-gamma production than in TCL established from healthy controls, indicating that the low production of IFN-gamma by PPD-specific T cells from atopic patients is not due to an intrinsic T cell defect but to some regulatory mechanisms.	Tetradecanoylphorbol Acetate	80-105	interferon gamma	Homo sapiens	236-245
8943722-7	1996	However, IL-1 beta, IL-2 and TNF-alpha mRNA levels of lymph node cells from CD4- mice could be upregulated by phorbol myristate acetate in vitro.	Tetradecanoylphorbol Acetate	110-135	interleukin 1 beta	Mus musculus	9-18
8898893-2	1996	The PAI-2 gene is one of the most TNF-responsive genes known and is also highly induced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the phosphatase inhibitor, okadaic acid, in both HT-1080 fibrosarcoma and U-937 histiocytic cells.	Tetradecanoylphorbol Acetate	109-140	tumor necrosis factor	Homo sapiens	34-37
8898893-2	1996	The PAI-2 gene is one of the most TNF-responsive genes known and is also highly induced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the phosphatase inhibitor, okadaic acid, in both HT-1080 fibrosarcoma and U-937 histiocytic cells.	Tetradecanoylphorbol Acetate	142-145	tumor necrosis factor	Homo sapiens	34-37
8943722-7	1996	However, IL-1 beta, IL-2 and TNF-alpha mRNA levels of lymph node cells from CD4- mice could be upregulated by phorbol myristate acetate in vitro.	Tetradecanoylphorbol Acetate	110-135	tumor necrosis factor	Mus musculus	29-38
8820825-6	1996	Other studies showed that 24-hr treatment with 100 nM of phorbol 12-myristate 13-acetate (PMA), resulted in the downregulation of PKCalpha, delta, and eta, and the 82-kDa PKCzeta band.	Tetradecanoylphorbol Acetate	57-88	protein kinase C, alpha	Mus musculus	130-138
8816467-9	1996	Treatment of the mature B-cell line BAL-17 with either anti-immunoglobulin M or phorbol 12-myristate 13-acetate leads to an increase in bcl-2 expression that is mediated by the CRE site.	Tetradecanoylphorbol Acetate	80-111	BCL2 apoptosis regulator	Homo sapiens	136-141
21541584-12	1996	The mean TPA percentage was significantly higher in the p53-positive tumors or tumor components (EC and YST) when compared with the mean TPA percentage in those neoplasms that were focally positive or negative for p53 protein (Ki-67, P=0.003; PCNA, P=0.046).	Tetradecanoylphorbol Acetate	9-12	tumor protein p53	Homo sapiens	56-59
21541584-13	1996	p53 expression was also associated with histologically aggressive tumors (ECs and YSTs) that also exhibit high TPA.	Tetradecanoylphorbol Acetate	111-114	tumor protein p53	Homo sapiens	0-3
8843226-0	1996	Decreased phorbol myristate acetate-induced release of tumor necrosis factor-alpha and interleukin-1 beta from peripheral blood monocytes of patients chronically infected with hepatitis C virus.	Tetradecanoylphorbol Acetate	10-35	tumor necrosis factor	Homo sapiens	55-82
8843226-0	1996	Decreased phorbol myristate acetate-induced release of tumor necrosis factor-alpha and interleukin-1 beta from peripheral blood monocytes of patients chronically infected with hepatitis C virus.	Tetradecanoylphorbol Acetate	10-35	interleukin 1 beta	Homo sapiens	87-105
8863815-1	1996	Gastrin-releasing peptide and other bombesin-like peptides stimulate secretion, cell proliferation, and smooth muscle contraction via a family of G protein-coupled receptors that activate phospholipase C. Second messenger formation by one of these receptors, called BR1, is rapidly desensitized after treatment of cells with either agonists or the protein kinase C activator 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	375-411	gastrin releasing peptide	Mus musculus	0-25
8863815-1	1996	Gastrin-releasing peptide and other bombesin-like peptides stimulate secretion, cell proliferation, and smooth muscle contraction via a family of G protein-coupled receptors that activate phospholipase C. Second messenger formation by one of these receptors, called BR1, is rapidly desensitized after treatment of cells with either agonists or the protein kinase C activator 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	413-416	gastrin releasing peptide	Mus musculus	0-25
8798623-5	1996	Phorbol 12-myristate 13-acetate, which increases the expression of CYP2E1 in this model, increased the toxicity by ethanol.	Tetradecanoylphorbol Acetate	0-31	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	67-73
8887449-3	1996	When EL-4 thymoma cells were stimulated with phorbol 12-myristate 13-acetate plus ionomycin in the presence of 500 ng/ml VT, DNA binding activity by NF-kappaB/Rel in nuclear extracts was increased from 2 to 48 hr when compared to controls employing no VT. VT preferentially induced a slower migrating electrophoretic band of the NF-kappaB/Rel complex particularly in later time points (8-48 hr).	Tetradecanoylphorbol Acetate	45-76	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	149-158
8887449-3	1996	When EL-4 thymoma cells were stimulated with phorbol 12-myristate 13-acetate plus ionomycin in the presence of 500 ng/ml VT, DNA binding activity by NF-kappaB/Rel in nuclear extracts was increased from 2 to 48 hr when compared to controls employing no VT. VT preferentially induced a slower migrating electrophoretic band of the NF-kappaB/Rel complex particularly in later time points (8-48 hr).	Tetradecanoylphorbol Acetate	45-76	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	329-338
8927716-8	1996	Phorbol 12-myristate 13-acetate (PMA) induced phosphorylation of p53 and pRb1O5 in MCF-7 cells, but EMF exposure had no effect.	Tetradecanoylphorbol Acetate	0-31	tumor protein p53	Homo sapiens	65-68
8927716-8	1996	Phorbol 12-myristate 13-acetate (PMA) induced phosphorylation of p53 and pRb1O5 in MCF-7 cells, but EMF exposure had no effect.	Tetradecanoylphorbol Acetate	33-36	tumor protein p53	Homo sapiens	65-68
8798560-1	1996	Although the involvement of protein kinase C (PKC) in the activation of the mitogen-activated protein (MAP) kinase pathway has been implicated through experiments using 12-O-tetradecanoylphorbol-13-acetate (TPA), there has been no direct demonstration that PKC activates the MAP kinase pathway.	Tetradecanoylphorbol Acetate	169-205	protein kinase C alpha	Homo sapiens	46-49
8831677-5	1996	By comparison, dual stimulation of Jurkat cells with phytohemagglutinin (PHA) plus phorbol (PMA) induced 9-10 fold increases in NF kappa B CAT activity.	Tetradecanoylphorbol Acetate	92-95	nuclear factor kappa B subunit 1	Homo sapiens	128-138
8841458-5	1996	However, TPA markedly enhanced the expression of 121-, 165- and 189-amino-acid-containing isoforms of VPF/VEGF mRNA in T cells.	Tetradecanoylphorbol Acetate	9-12	vascular endothelial growth factor A	Homo sapiens	102-105
8841458-5	1996	However, TPA markedly enhanced the expression of 121-, 165- and 189-amino-acid-containing isoforms of VPF/VEGF mRNA in T cells.	Tetradecanoylphorbol Acetate	9-12	vascular endothelial growth factor A	Homo sapiens	106-110
8841458-6	1996	Both CD4+ and CD8+ T cells expressed VPF/VEGF mRNA in response to TPA treatment.	Tetradecanoylphorbol Acetate	66-69	vascular endothelial growth factor A	Homo sapiens	37-40
8841458-6	1996	Both CD4+ and CD8+ T cells expressed VPF/VEGF mRNA in response to TPA treatment.	Tetradecanoylphorbol Acetate	66-69	vascular endothelial growth factor A	Homo sapiens	41-45
8798560-1	1996	Although the involvement of protein kinase C (PKC) in the activation of the mitogen-activated protein (MAP) kinase pathway has been implicated through experiments using 12-O-tetradecanoylphorbol-13-acetate (TPA), there has been no direct demonstration that PKC activates the MAP kinase pathway.	Tetradecanoylphorbol Acetate	207-210	protein kinase C alpha	Homo sapiens	46-49
8798560-3	1996	Treatment of cells with TPA or epidermal growth factor resulted in the activation of MEK and ERK.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase kinase 7	Homo sapiens	85-88
8798560-3	1996	Treatment of cells with TPA or epidermal growth factor resulted in the activation of MEK and ERK.	Tetradecanoylphorbol Acetate	24-27	mitogen-activated protein kinase 1	Homo sapiens	93-96
8964090-9	1996	Furthermore, acute exposure of K562 cells to known protein kinase C (PKC) activators, phorbol-12-myristate-13-acetate (PMA) and sn-1,2-dioctanoylglycerol (DiC8), curtailed serotonin uptake by these cells.	Tetradecanoylphorbol Acetate	86-117	proline rich transmembrane protein 2	Homo sapiens	51-67
8964090-9	1996	Furthermore, acute exposure of K562 cells to known protein kinase C (PKC) activators, phorbol-12-myristate-13-acetate (PMA) and sn-1,2-dioctanoylglycerol (DiC8), curtailed serotonin uptake by these cells.	Tetradecanoylphorbol Acetate	86-117	proline rich transmembrane protein 2	Homo sapiens	69-72
8798441-6	1996	Treatment with phorbol 12-myristate 13-acetate (PMA) led to an increase in both the amount of phosphorylated CREB and the bcl-2 promoter activity.	Tetradecanoylphorbol Acetate	48-51	BCL2 apoptosis regulator	Homo sapiens	122-127
8798409-1	1996	We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A).	Tetradecanoylphorbol Acetate	51-82	interleukin 6	Homo sapiens	109-122
8798409-1	1996	We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A).	Tetradecanoylphorbol Acetate	51-82	interleukin 6	Homo sapiens	124-128
8798409-1	1996	We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A).	Tetradecanoylphorbol Acetate	51-82	signal transducer and activator of transcription 3	Homo sapiens	169-221
8798409-1	1996	We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A).	Tetradecanoylphorbol Acetate	51-82	signal transducer and activator of transcription 3	Homo sapiens	223-228
8798409-1	1996	We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A).	Tetradecanoylphorbol Acetate	84-87	interleukin 6	Homo sapiens	109-122
8798409-1	1996	We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A).	Tetradecanoylphorbol Acetate	84-87	interleukin 6	Homo sapiens	124-128
8798409-1	1996	We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A).	Tetradecanoylphorbol Acetate	84-87	signal transducer and activator of transcription 3	Homo sapiens	169-221
8798409-1	1996	We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A).	Tetradecanoylphorbol Acetate	84-87	signal transducer and activator of transcription 3	Homo sapiens	223-228
8798386-3	1996	Activation of ERK2 by the 5-HT1A receptor-selective agonist 8-hydroxy-N,N-dipropyl-2-aminotetralin hydrobromide (8-OH-DPAT) was inhibited completely by pertussis toxin and substantially by prolonged treatment of cells with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	223-254	mitogen-activated protein kinase 1	Homo sapiens	14-18
8798441-6	1996	Treatment with phorbol 12-myristate 13-acetate (PMA) led to an increase in both the amount of phosphorylated CREB and the bcl-2 promoter activity.	Tetradecanoylphorbol Acetate	15-46	BCL2 apoptosis regulator	Homo sapiens	122-127
8782659-6	1996	Similarly, growth inhibition and aromatase stimulation in response to TPA were both further enhanced by IL-1beta treatment.	Tetradecanoylphorbol Acetate	70-73	interleukin 1 beta	Homo sapiens	104-112
8826848-3	1996	Tumour necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) increased in several, but not all, cell lines the production of urokinase-type plasminogen activator (uPA), tissue-type PA (tPA) and plasminogen activator inhibitor type 1 (PAI-1) as analysed by zymography, enzyme immunoassays and Northern analysis.	Tetradecanoylphorbol Acetate	200-203	tumor necrosis factor	Homo sapiens	30-39
8826848-3	1996	Tumour necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) increased in several, but not all, cell lines the production of urokinase-type plasminogen activator (uPA), tissue-type PA (tPA) and plasminogen activator inhibitor type 1 (PAI-1) as analysed by zymography, enzyme immunoassays and Northern analysis.	Tetradecanoylphorbol Acetate	200-203	interleukin 1 beta	Homo sapiens	45-63
8826848-3	1996	Tumour necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) increased in several, but not all, cell lines the production of urokinase-type plasminogen activator (uPA), tissue-type PA (tPA) and plasminogen activator inhibitor type 1 (PAI-1) as analysed by zymography, enzyme immunoassays and Northern analysis.	Tetradecanoylphorbol Acetate	200-203	interleukin 1 beta	Homo sapiens	65-74
8891268-5	1996	This was in contrast to forskolin + phorbol 12 myristate 13-acetate (PMA) which were highly effective in inducing NPY production, verifying that expression of NPY is a regulated process in these cultures.	Tetradecanoylphorbol Acetate	36-67	neuropeptide Y	Rattus norvegicus	114-117
8891268-5	1996	This was in contrast to forskolin + phorbol 12 myristate 13-acetate (PMA) which were highly effective in inducing NPY production, verifying that expression of NPY is a regulated process in these cultures.	Tetradecanoylphorbol Acetate	36-67	neuropeptide Y	Rattus norvegicus	159-162
8891268-5	1996	This was in contrast to forskolin + phorbol 12 myristate 13-acetate (PMA) which were highly effective in inducing NPY production, verifying that expression of NPY is a regulated process in these cultures.	Tetradecanoylphorbol Acetate	69-72	neuropeptide Y	Rattus norvegicus	114-117
8891268-5	1996	This was in contrast to forskolin + phorbol 12 myristate 13-acetate (PMA) which were highly effective in inducing NPY production, verifying that expression of NPY is a regulated process in these cultures.	Tetradecanoylphorbol Acetate	69-72	neuropeptide Y	Rattus norvegicus	159-162
8843732-5	1996	However, stimulation of mouse islets with the protein kinase C (PKC) activator tetradecanoyl phorbol acetate (TPA) or the muscarinic agonist carbachol, which significantly activates an isozyme of PLC distinct from that activated by high glucose, induces a rising and sustained second-phase insulin secretory response.	Tetradecanoylphorbol Acetate	79-108	insulin	Homo sapiens	290-297
8843732-5	1996	However, stimulation of mouse islets with the protein kinase C (PKC) activator tetradecanoyl phorbol acetate (TPA) or the muscarinic agonist carbachol, which significantly activates an isozyme of PLC distinct from that activated by high glucose, induces a rising and sustained second-phase insulin secretory response.	Tetradecanoylphorbol Acetate	110-113	insulin	Homo sapiens	290-297
8781494-5	1996	PKC inhibition with 4 mumol/L bisindolyImaleimide I and PKC depletion (alpha, mu, iota, and zeta) with 24-hour exposure to 200 nmol/L phorbol 12-myristate 13-acetate in RASMCs eliminated the mitogenic effects of oleic acid but did not reduce responses to 10% FBS.	Tetradecanoylphorbol Acetate	134-165	proline rich transmembrane protein 2	Homo sapiens	0-3
8824534-2	1996	Levels of iNOS mRNA in dorsal skin isolated from acetone-treated female Sencar mice were 2.5-fold higher than iNOS gene expression detected in cutaneous tissue isolated from Sencar mice at 1, 3, 6, 10, 16 and 22 weeks after exposure to a single topical application of 25 nmol 7,12-dimethylbenz[a]anthracene (DMBA) followed by repetitive applications of 2 microgram 17-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	403-406	nitric oxide synthase 2, inducible	Mus musculus	10-14
8824534-4	1996	The diminished levels of iNOS mRNA inversely correlated with the extent of TPA-induced epidermal hyperplasia.	Tetradecanoylphorbol Acetate	75-78	nitric oxide synthase 2, inducible	Mus musculus	25-29
8824534-6	1996	In contrast, iNOS protein was present in lower amounts and was localized to the upper-most suprabasal keratinocytes in cutaneous tissue isolated at 22 weeks following a single exposure to either 25 nmol DMBA or acetone and repetitive applications of 2 microgram TPA.	Tetradecanoylphorbol Acetate	262-265	nitric oxide synthase 2, inducible	Mus musculus	13-17
8781494-5	1996	PKC inhibition with 4 mumol/L bisindolyImaleimide I and PKC depletion (alpha, mu, iota, and zeta) with 24-hour exposure to 200 nmol/L phorbol 12-myristate 13-acetate in RASMCs eliminated the mitogenic effects of oleic acid but did not reduce responses to 10% FBS.	Tetradecanoylphorbol Acetate	134-165	proline rich transmembrane protein 2	Homo sapiens	56-59
8877100-5	1996	Compared with control clones, PKC-alpha- and -beta-overexpressing MCF-7 cells exhibited more drastic morphological changes in response to phorbol 12-myristate 13-acetate administration characterized by cellular flattening and vacuolization.	Tetradecanoylphorbol Acetate	138-169	protein kinase C alpha	Homo sapiens	30-39
8872603-9	1996	Super-shift assays using the TRE of the HO gene revealed that the Fos and Jun proteins from nuclei of M1 cells treated with TPA bound to the TRE, and same assays using DNA with the NF-kappa B motif also revealed that the active NF-kappa B protein from M1 cells treated with H2O2 or TPA also bound to the corresponding motif.	Tetradecanoylphorbol Acetate	124-127	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	181-191
8877124-5	1996	Upon stimulation with phytohemagglutinin (PHA) plus phorbol-12-myristate-13-acetate (PMA), RP children produced less IL-2 (P &lt; 0.01) and IFN-gamma (P &lt; 0.02) than SR children and also expressed significantly less IFN-gamma mRNA (P &lt; 0.01) than SR children.	Tetradecanoylphorbol Acetate	52-83	interleukin 2	Homo sapiens	117-121
8877124-5	1996	Upon stimulation with phytohemagglutinin (PHA) plus phorbol-12-myristate-13-acetate (PMA), RP children produced less IL-2 (P &lt; 0.01) and IFN-gamma (P &lt; 0.02) than SR children and also expressed significantly less IFN-gamma mRNA (P &lt; 0.01) than SR children.	Tetradecanoylphorbol Acetate	52-83	interferon gamma	Homo sapiens	140-149
8877124-5	1996	Upon stimulation with phytohemagglutinin (PHA) plus phorbol-12-myristate-13-acetate (PMA), RP children produced less IL-2 (P &lt; 0.01) and IFN-gamma (P &lt; 0.02) than SR children and also expressed significantly less IFN-gamma mRNA (P &lt; 0.01) than SR children.	Tetradecanoylphorbol Acetate	52-83	interferon gamma	Homo sapiens	219-228
8877133-4	1996	For ACH-2 cells stimulated with phorbol 12-myristate 13-acetate (PMA; 50 ng/ml), IL-12 and IL-15 significantly increased p24 antigen production by 20 and 30%, respectively (n = 6).	Tetradecanoylphorbol Acetate	65-68	transmembrane p24 trafficking protein 2	Homo sapiens	121-124
8878412-3	1996	Treatment of MCF-7 cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (100 nM) was associated with a high expression of MMP-1 mRNA, as well as an induction of the level of TIMP-1 mRNA (5- to 10-fold).	Tetradecanoylphorbol Acetate	48-84	TIMP metallopeptidase inhibitor 1	Homo sapiens	193-199
8878412-3	1996	Treatment of MCF-7 cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (100 nM) was associated with a high expression of MMP-1 mRNA, as well as an induction of the level of TIMP-1 mRNA (5- to 10-fold).	Tetradecanoylphorbol Acetate	86-89	TIMP metallopeptidase inhibitor 1	Homo sapiens	193-199
8878412-7	1996	The level of pS2 mRNA, of which the induction by TPA in MCF-7 cells is a primary transcriptional event, was up-regulated (10- to 15-fold) by TPA (100 nM), whereas a much weaker increase (2- to 3-fold) was observed by treatment with N6-Bzl-cAMP (500 microM).	Tetradecanoylphorbol Acetate	49-52	taste 2 receptor member 64 pseudogene	Homo sapiens	13-16
8878412-7	1996	The level of pS2 mRNA, of which the induction by TPA in MCF-7 cells is a primary transcriptional event, was up-regulated (10- to 15-fold) by TPA (100 nM), whereas a much weaker increase (2- to 3-fold) was observed by treatment with N6-Bzl-cAMP (500 microM).	Tetradecanoylphorbol Acetate	141-144	taste 2 receptor member 64 pseudogene	Homo sapiens	13-16
8814250-6	1996	Functional helper T cells (Th1 and Th2) were induced from the CD4 lineage-committed cells upon secondary stimulation with a combination of ionomycin and PMA followed by lymphokine treatment.	Tetradecanoylphorbol Acetate	153-156	negative elongation factor complex member C/D, Th1l	Mus musculus	27-30
8872603-9	1996	Super-shift assays using the TRE of the HO gene revealed that the Fos and Jun proteins from nuclei of M1 cells treated with TPA bound to the TRE, and same assays using DNA with the NF-kappa B motif also revealed that the active NF-kappa B protein from M1 cells treated with H2O2 or TPA also bound to the corresponding motif.	Tetradecanoylphorbol Acetate	124-127	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	228-238
8872603-9	1996	Super-shift assays using the TRE of the HO gene revealed that the Fos and Jun proteins from nuclei of M1 cells treated with TPA bound to the TRE, and same assays using DNA with the NF-kappa B motif also revealed that the active NF-kappa B protein from M1 cells treated with H2O2 or TPA also bound to the corresponding motif.	Tetradecanoylphorbol Acetate	282-285	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	228-238
8872603-10	1996	These results strongly suggest that the HO gene in M1 cells is activated by TPA through a production of H2O2, an oxidative activation pathway of NF-kappa B, and a signal-transduction pathway that involves C-kinase during the differentiation of macrophages that occurs upon treatment with TPA.	Tetradecanoylphorbol Acetate	76-79	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-155
8872603-10	1996	These results strongly suggest that the HO gene in M1 cells is activated by TPA through a production of H2O2, an oxidative activation pathway of NF-kappa B, and a signal-transduction pathway that involves C-kinase during the differentiation of macrophages that occurs upon treatment with TPA.	Tetradecanoylphorbol Acetate	288-291	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-155
8751970-1	1996	Treatment of mice with multiple topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) or diacylglycerol resulted in a preferential decrease in epidermal protein kinase C-beta 2 (PKC-beta 2) compared with PKC-alpha as determined by western analysis.	Tetradecanoylphorbol Acetate	56-92	protein kinase C, alpha	Mus musculus	217-226
8751970-1	1996	Treatment of mice with multiple topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) or diacylglycerol resulted in a preferential decrease in epidermal protein kinase C-beta 2 (PKC-beta 2) compared with PKC-alpha as determined by western analysis.	Tetradecanoylphorbol Acetate	94-97	protein kinase C, alpha	Mus musculus	217-226
8751970-2	1996	When PKC-alpha was decreased by 40%, PKC-beta 2 could no longer be detected, suggesting that PKC-beta 2 is more sensitive to downregulation, and/or specific epidermal cell types that contain PKC-beta 2 are more sensitive to TPA/diacylglycerol.	Tetradecanoylphorbol Acetate	224-227	protein kinase C, alpha	Mus musculus	5-14
8906581-5	1996	12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells.	Tetradecanoylphorbol Acetate	38-41	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	67-82
8895049-9	1996	Thus, human cholesterol 7 alpha-hydroxylase gene promoter is strongly repressed by insulin, PMA, and steroid/thyroid hormones and results in the low level of cholesterol 7 alpha-hydroxylase expression in the human liver.	Tetradecanoylphorbol Acetate	92-95	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	12-43
8895049-9	1996	Thus, human cholesterol 7 alpha-hydroxylase gene promoter is strongly repressed by insulin, PMA, and steroid/thyroid hormones and results in the low level of cholesterol 7 alpha-hydroxylase expression in the human liver.	Tetradecanoylphorbol Acetate	92-95	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	158-189
8906565-9	1996	A monoclonal antibody to phosphatidylinositol 4-kinase inhibits PIP2 synthesis in permeabilized U937 cells and blocks PLD activation by GTP gamma S and TPA.	Tetradecanoylphorbol Acetate	152-155	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	118-121
8906581-5	1996	12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells.	Tetradecanoylphorbol Acetate	38-41	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	84-87
8752106-8	1996	With low concentrations of PACAP38 or PACAP27, the effect of PMA was inhibitory, whereas at higher concentrations of PACAP (&gt; 1 nM), the effect of PMA was stimulatory.	Tetradecanoylphorbol Acetate	61-64	adenylate cyclase activating polypeptide 1	Mus musculus	27-32
8875488-6	1996	RESULTS: TPA consistently stimulated GH secretion by cultured somatotrophinoma cells.	Tetradecanoylphorbol Acetate	9-12	growth hormone 1	Homo sapiens	37-39
8781293-7	1996	Phorbol myristate acetate (PMA), which causes NADPH oxidase activation in J-774 A.1 macrophages, had no significant effect on 15-lipoxygenase activity, but still resulted in cell-mediated oxidation of LDL.	Tetradecanoylphorbol Acetate	0-25	dual oxidase 2	Homo sapiens	46-59
8781293-7	1996	Phorbol myristate acetate (PMA), which causes NADPH oxidase activation in J-774 A.1 macrophages, had no significant effect on 15-lipoxygenase activity, but still resulted in cell-mediated oxidation of LDL.	Tetradecanoylphorbol Acetate	27-30	dual oxidase 2	Homo sapiens	46-59
8804365-7	1996	The PLD activity was inhibited by reducing extracellular calcium (150 nM, 50% inhibition), exposure to 12-O-tetradecanoylphorbol 13 acetate (200 nM, 24 hours, 100% inhibition), Roche 31,8220 (10 microM, 15 minutes, 72% inhibition), or genestein (100 microM, 30 minutes, 56% inhibition), which suggests a dependence on both protein kinase C and tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	103-139	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-7
8875488-8	1996	Tumors in which GHRH had no significant effect nevertheless responded to TPA.	Tetradecanoylphorbol Acetate	73-76	growth hormone releasing hormone	Homo sapiens	16-20
8875488-10	1996	TPA treatment of cultured somatotrophinoma cells eventually resulted in suppression of inositol 1,4,5-trisphosphate production, probably reflecting down-regulation of membrane phosphatidylinositol hydrolysis, a second messenger system that also generates the endogenous PKC activator diacylglycerol.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	270-273
8896174-0	1996	A novel monoclonal antibody mNI-58A against the alpha-chain of leukocyte function-associated antigen-1 (LFA-1) blocks the homotypic cell aggregation and actively regulates morphological changes in the phorbol myristate acetate (PMA)-activated human monocyte-like cell line, U937.	Tetradecanoylphorbol Acetate	201-226	Fc gamma receptor and transporter	Homo sapiens	48-59
8896174-0	1996	A novel monoclonal antibody mNI-58A against the alpha-chain of leukocyte function-associated antigen-1 (LFA-1) blocks the homotypic cell aggregation and actively regulates morphological changes in the phorbol myristate acetate (PMA)-activated human monocyte-like cell line, U937.	Tetradecanoylphorbol Acetate	228-231	Fc gamma receptor and transporter	Homo sapiens	48-59
8898346-6	1996	TPA, a phorbol ester which induced a rapid and important redistribution of PKC, although unable to elicit PLC or PLA2 stimulation, specifically provoked PLD activation in a PKC-dependent but Ca(2+)-independent manner.	Tetradecanoylphorbol Acetate	0-3	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	153-156
8702956-0	1996	Protein kinase C isozymes differentially regulate promoters containing PEA-3/12-O-tetradecanoylphorbol-13-acetate response element motifs.	Tetradecanoylphorbol Acetate	77-113	proline rich transmembrane protein 2	Homo sapiens	0-16
8873120-3	1996	It is shown that, in Neuro 2a cells, activation of protein kinase C by addition of 4 beta-phorbol-12 beta-myristate-13 alpha-acetate (PMA), leads to phosphorylation of Raf and Mitogen-activated protein kinase (MAP kinase).	Tetradecanoylphorbol Acetate	134-137	zinc fingers and homeoboxes 2	Mus musculus	168-171
8702771-7	1996	Both intimin and invasin, immobilized on plastic surfaces, mediated adherence of resting or phorbol 12-myristate 13-acetate-activated human CD4(+) T cells, whereas fibronectin mediated the adherence of only activated T cells.	Tetradecanoylphorbol Acetate	92-123	CD4 molecule	Homo sapiens	140-143
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Homo sapiens	123-141
8687492-4	1996	Complete down-regulation of PKC from MCF-7/Dox cells by 24-hr preincubation with PMA did not alter the degree of Dox resistance.	Tetradecanoylphorbol Acetate	81-84	protein kinase C alpha	Homo sapiens	28-31
8687492-9	1996	H7 did not affect the basal level of P-glycoprotein in cells from control colonies or PMA-induced overexpression of P-glycoprotein in cells from PMA-treated colonies.	Tetradecanoylphorbol Acetate	86-89	ATP binding cassette subfamily B member 1	Homo sapiens	116-130
8687492-13	1996	Differential effects of H7 on the PMA-induced changes suggest that different isoforms of PKC may be involved in cell growth and drug accumulation processes as well as P-glycoprotein expression.	Tetradecanoylphorbol Acetate	34-37	protein kinase C alpha	Homo sapiens	89-92
8687492-13	1996	Differential effects of H7 on the PMA-induced changes suggest that different isoforms of PKC may be involved in cell growth and drug accumulation processes as well as P-glycoprotein expression.	Tetradecanoylphorbol Acetate	34-37	ATP binding cassette subfamily B member 1	Homo sapiens	167-181
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Homo sapiens	143-152
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Homo sapiens	178-187
8753812-1	1996	The human monocytic leukemic cell line, THP-1, which differentiates toward macrophages in response to phorbol 12-myristate 13-acetate (PMA) was investigated for its ability to produce granulocyte colony-stimulating factor (G-CSF).	Tetradecanoylphorbol Acetate	102-133	GLI family zinc finger 2	Homo sapiens	40-45
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	interleukin 1 beta	Homo sapiens	37-41
8753812-1	1996	The human monocytic leukemic cell line, THP-1, which differentiates toward macrophages in response to phorbol 12-myristate 13-acetate (PMA) was investigated for its ability to produce granulocyte colony-stimulating factor (G-CSF).	Tetradecanoylphorbol Acetate	135-138	GLI family zinc finger 2	Homo sapiens	40-45
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	GLI family zinc finger 2	Homo sapiens	103-108
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	interleukin 1 beta	Homo sapiens	339-343
8871052-6	1996	In three out of nine clones tested, the stimulation with anti-CD2/CD28/phorbol myristate acetate (PMA) induced a shift of the IFN-gamma/IL-4 ratio towards a Th2-type cytokine profile.	Tetradecanoylphorbol Acetate	71-96	interferon gamma	Homo sapiens	126-135
8770045-7	1996	Finally, cholesterol 7 alpha-hydroxylase mRNA was repressed &gt; 75% by phorbol 12-myristate 13-acetate (100 nM for 3 h), a nonselective activator of PKC isoforms.	Tetradecanoylphorbol Acetate	72-103	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	9-40
8866006-2	1996	Phorbol myristate acetate (PMA), a potent PKC activator, stimulated fibronectin synthesis in both normal and transformed fibroblasts in a time and dose dependent fashion.	Tetradecanoylphorbol Acetate	0-25	fibronectin 1	Homo sapiens	68-79
8866006-2	1996	Phorbol myristate acetate (PMA), a potent PKC activator, stimulated fibronectin synthesis in both normal and transformed fibroblasts in a time and dose dependent fashion.	Tetradecanoylphorbol Acetate	27-30	fibronectin 1	Homo sapiens	68-79
8761432-1	1996	Topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal epidermis of Sencar mice induces synthesis of pro-inflammatory cytokines, including interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	23-59	tumor necrosis factor	Mus musculus	201-228
8761432-1	1996	Topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal epidermis of Sencar mice induces synthesis of pro-inflammatory cytokines, including interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	23-59	tumor necrosis factor	Mus musculus	230-239
8761432-1	1996	Topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal epidermis of Sencar mice induces synthesis of pro-inflammatory cytokines, including interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	61-64	tumor necrosis factor	Mus musculus	201-228
8761432-1	1996	Topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal epidermis of Sencar mice induces synthesis of pro-inflammatory cytokines, including interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	61-64	tumor necrosis factor	Mus musculus	230-239
8761432-5	1996	Intraperitoneal injection of 50 micrograms/g pentoxifylline at 30 min prior to topical application of 10 micrograms TPA to the dorsal epidermis of Sencar mice inhibited TPA-induced IL-1 alpha and TNF-alpha gene expression 24 h after TPA treatment.	Tetradecanoylphorbol Acetate	116-119	tumor necrosis factor	Mus musculus	196-205
8761432-5	1996	Intraperitoneal injection of 50 micrograms/g pentoxifylline at 30 min prior to topical application of 10 micrograms TPA to the dorsal epidermis of Sencar mice inhibited TPA-induced IL-1 alpha and TNF-alpha gene expression 24 h after TPA treatment.	Tetradecanoylphorbol Acetate	169-172	tumor necrosis factor	Mus musculus	196-205
8761432-5	1996	Intraperitoneal injection of 50 micrograms/g pentoxifylline at 30 min prior to topical application of 10 micrograms TPA to the dorsal epidermis of Sencar mice inhibited TPA-induced IL-1 alpha and TNF-alpha gene expression 24 h after TPA treatment.	Tetradecanoylphorbol Acetate	169-172	tumor necrosis factor	Mus musculus	196-205
8774728-12	1996	Treatment with 30 nM TPA for 24 h completely depleted KB-3 cells of PKC alpha whereas 1 microM TPA was required to deplete KB-V1 cells of PKC alpha.	Tetradecanoylphorbol Acetate	21-24	protein kinase C alpha	Homo sapiens	68-77
8774728-12	1996	Treatment with 30 nM TPA for 24 h completely depleted KB-3 cells of PKC alpha whereas 1 microM TPA was required to deplete KB-V1 cells of PKC alpha.	Tetradecanoylphorbol Acetate	95-98	protein kinase C alpha	Homo sapiens	138-147
8774728-14	1996	Defective TPA-mediated down-regulation of PKC alpha was also observed in another PKC alpha-overexpressing MDR cell line.	Tetradecanoylphorbol Acetate	10-13	protein kinase C alpha	Homo sapiens	42-51
8774728-14	1996	Defective TPA-mediated down-regulation of PKC alpha was also observed in another PKC alpha-overexpressing MDR cell line.	Tetradecanoylphorbol Acetate	10-13	protein kinase C alpha	Homo sapiens	81-90
8764555-2	1996	Further, increased MAPK activity occurred following IL-2 stimulation, but not following phorbol 12-myristate 13-acetate (PMA) stimulation in cells depleted of PKC by prolonged treatment with a high concentration of PMA.	Tetradecanoylphorbol Acetate	215-218	mitogen-activated protein kinase 3	Homo sapiens	19-23
8754760-7	1996	Incubation of AsPc1 cells with the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate resulted in a time- and dose-dependent selective down-regulation of PKC alpha but not zeta.	Tetradecanoylphorbol Acetate	49-86	protein kinase C alpha	Homo sapiens	155-164
8871061-4	1996	Subsequent analysis of the human ICAM-1 promoter has revealed that both 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumour necrosis factor-alpha (TNF-alpha) upregulate ICAM-1 expression through the presence of a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC).	Tetradecanoylphorbol Acetate	72-108	nuclear factor kappa B subunit 1	Homo sapiens	231-241
8871061-4	1996	Subsequent analysis of the human ICAM-1 promoter has revealed that both 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumour necrosis factor-alpha (TNF-alpha) upregulate ICAM-1 expression through the presence of a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC).	Tetradecanoylphorbol Acetate	110-113	nuclear factor kappa B subunit 1	Homo sapiens	231-241
8871052-6	1996	In three out of nine clones tested, the stimulation with anti-CD2/CD28/phorbol myristate acetate (PMA) induced a shift of the IFN-gamma/IL-4 ratio towards a Th2-type cytokine profile.	Tetradecanoylphorbol Acetate	71-96	interleukin 4	Homo sapiens	136-140
8871052-6	1996	In three out of nine clones tested, the stimulation with anti-CD2/CD28/phorbol myristate acetate (PMA) induced a shift of the IFN-gamma/IL-4 ratio towards a Th2-type cytokine profile.	Tetradecanoylphorbol Acetate	98-101	interferon gamma	Homo sapiens	126-135
8871052-6	1996	In three out of nine clones tested, the stimulation with anti-CD2/CD28/phorbol myristate acetate (PMA) induced a shift of the IFN-gamma/IL-4 ratio towards a Th2-type cytokine profile.	Tetradecanoylphorbol Acetate	98-101	interleukin 4	Homo sapiens	136-140
8698875-5	1996	While Th cells from normal subjects (n = 14) and rheumatic disease control patients (n = 9) showed maximal expression of CD40L, after in vitro activation with phorbol myristate acetate (PMA) and ionomycin, at 6 h of culture with diminished levels observed at 24 and 48 h, Th cells from SLE patients (n = 19) maintained high level cell surface expression of CD40L through 24 and 48 h of culture.	Tetradecanoylphorbol Acetate	159-184	CD40 ligand	Homo sapiens	121-126
8872491-1	1996	We have previously shown that interferon-gamma (IFN-gamma) increases intracellular levels of the lysosomal proteinase, CB, in THP-1 cell primed with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	149-180	interferon gamma	Homo sapiens	30-46
8872491-1	1996	We have previously shown that interferon-gamma (IFN-gamma) increases intracellular levels of the lysosomal proteinase, CB, in THP-1 cell primed with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	149-180	interferon gamma	Homo sapiens	48-57
8872491-1	1996	We have previously shown that interferon-gamma (IFN-gamma) increases intracellular levels of the lysosomal proteinase, CB, in THP-1 cell primed with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	182-185	interferon gamma	Homo sapiens	30-46
8872491-1	1996	We have previously shown that interferon-gamma (IFN-gamma) increases intracellular levels of the lysosomal proteinase, CB, in THP-1 cell primed with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	182-185	interferon gamma	Homo sapiens	48-57
8698875-5	1996	While Th cells from normal subjects (n = 14) and rheumatic disease control patients (n = 9) showed maximal expression of CD40L, after in vitro activation with phorbol myristate acetate (PMA) and ionomycin, at 6 h of culture with diminished levels observed at 24 and 48 h, Th cells from SLE patients (n = 19) maintained high level cell surface expression of CD40L through 24 and 48 h of culture.	Tetradecanoylphorbol Acetate	186-189	CD40 ligand	Homo sapiens	121-126
8768715-2	1996	In this paper, we demonstrate that the release of arachidonate from human polymorphonuclear leukocytes (PMNL) via a pathway initiated by phospholipase D (PLD) mediates phorbol myristate acetate (PMA)-induced desensitization of leukotriene B4 (LTB4) receptors.	Tetradecanoylphorbol Acetate	168-193	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	137-152
8856479-4	1996	Translocation and down-regulation of PKC alpha and epsilon but not zeta were detected by short-term and long-term treatment with TPA (12-O-tetradecanoylphorbol 13-acetate), respectively.	Tetradecanoylphorbol Acetate	129-132	protein kinase C alpha	Homo sapiens	37-46
8856479-4	1996	Translocation and down-regulation of PKC alpha and epsilon but not zeta were detected by short-term and long-term treatment with TPA (12-O-tetradecanoylphorbol 13-acetate), respectively.	Tetradecanoylphorbol Acetate	134-170	protein kinase C alpha	Homo sapiens	37-46
8757771-7	1996	Immunocytochemical studies demonstrated that the isozymes are located in distinct cellular compartments and that following treatment with phorbol 12-myristate 13-acetate or with a collagen gel overlay, most isozymes (protein kinase C alpha, beta1, betaII, delta, epsilon, eta) translocated to different parts of the cell.	Tetradecanoylphorbol Acetate	138-169	protein kinase C alpha	Homo sapiens	217-239
8757771-7	1996	Immunocytochemical studies demonstrated that the isozymes are located in distinct cellular compartments and that following treatment with phorbol 12-myristate 13-acetate or with a collagen gel overlay, most isozymes (protein kinase C alpha, beta1, betaII, delta, epsilon, eta) translocated to different parts of the cell.	Tetradecanoylphorbol Acetate	138-169	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	241-275
8764613-6	1996	Staurosporine, a protein kinase C (PKC) inhibitor, had no effect on Et-1-induced AA release but abolished that by phorbol 12-myristate 13-acetate, demonstrating that the Et-1 response was PKC independent.	Tetradecanoylphorbol Acetate	114-145	endothelin 1	Homo sapiens	170-174
8768715-5	1996	The PMA-induced generation of these three PLD products was inhibited by mepacrine which, in parallel, significantly blocked PMA-induced desensitization of [3H]LTB4 binding, which suggested that elevation of one or more of these products played a role in desensitization.	Tetradecanoylphorbol Acetate	4-7	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	42-45
8768715-5	1996	The PMA-induced generation of these three PLD products was inhibited by mepacrine which, in parallel, significantly blocked PMA-induced desensitization of [3H]LTB4 binding, which suggested that elevation of one or more of these products played a role in desensitization.	Tetradecanoylphorbol Acetate	124-127	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	42-45
8768715-2	1996	In this paper, we demonstrate that the release of arachidonate from human polymorphonuclear leukocytes (PMNL) via a pathway initiated by phospholipase D (PLD) mediates phorbol myristate acetate (PMA)-induced desensitization of leukotriene B4 (LTB4) receptors.	Tetradecanoylphorbol Acetate	168-193	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	154-157
8768715-2	1996	In this paper, we demonstrate that the release of arachidonate from human polymorphonuclear leukocytes (PMNL) via a pathway initiated by phospholipase D (PLD) mediates phorbol myristate acetate (PMA)-induced desensitization of leukotriene B4 (LTB4) receptors.	Tetradecanoylphorbol Acetate	195-198	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	137-152
8768715-2	1996	In this paper, we demonstrate that the release of arachidonate from human polymorphonuclear leukocytes (PMNL) via a pathway initiated by phospholipase D (PLD) mediates phorbol myristate acetate (PMA)-induced desensitization of leukotriene B4 (LTB4) receptors.	Tetradecanoylphorbol Acetate	195-198	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	154-157
8703964-1	1996	We show here that the mode of cell death in IL-6-starved T1165 and T1198 plasmacytoma cell lines is apoptosis, and that it can be suppressed by phorbol ester (PMA) treatment in a protein kinase C (PKC)-mediated process that involves alpha and/or delta isozymes.	Tetradecanoylphorbol Acetate	159-162	interleukin 6	Mus musculus	44-48
8663368-5	1996	Translocation of PKC to the membrane by incubation of HIT cells for 10 min in the presence of 20 nM phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a 5-fold increase in glucose-induced insulin release.	Tetradecanoylphorbol Acetate	114-150	insulin	Homo sapiens	206-213
8663368-5	1996	Translocation of PKC to the membrane by incubation of HIT cells for 10 min in the presence of 20 nM phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a 5-fold increase in glucose-induced insulin release.	Tetradecanoylphorbol Acetate	152-155	insulin	Homo sapiens	206-213
8663368-7	1996	Cells pretreated with TPA demonstrated increased insulin secretion in response to glucose for several hours.	Tetradecanoylphorbol Acetate	22-25	insulin	Homo sapiens	49-56
8660843-4	1996	Stimulation of Jurkat cells with ionomycin and PMA in the presence of PGE2 inhibited the IL-2- but not the IL-4-promoter activity.	Tetradecanoylphorbol Acetate	47-50	interleukin 2	Homo sapiens	89-93
8702428-3	1996	In this study, we examined the effect of RA on expression of IL-1 beta and IL-ra in phorbol-myristate-acetate (PMA)-activated human monocytes.	Tetradecanoylphorbol Acetate	84-109	interleukin 1 beta	Homo sapiens	61-70
8702428-3	1996	In this study, we examined the effect of RA on expression of IL-1 beta and IL-ra in phorbol-myristate-acetate (PMA)-activated human monocytes.	Tetradecanoylphorbol Acetate	111-114	interleukin 1 beta	Homo sapiens	61-70
8707424-8	1996	Using TPA, the expression of ERV3 env was detected as 9- and 3.5-kb transcripts by Northern blotting, as mRNA by in situ hybridization and as a cytoplasmic 65-kDa protein by immunofluorescence and Western blots.	Tetradecanoylphorbol Acetate	6-9	endogenous retrovirus group W member 1, envelope	Homo sapiens	34-37
8702403-3	1996	NO2HPA was detected under PMA stimulation only in the presence of myeloperoxidase inhibitor.	Tetradecanoylphorbol Acetate	26-29	myeloperoxidase	Homo sapiens	66-81
8663100-7	1996	The MAPK and NHE activities induced by PMA were inhibited by staurosporine, a potent inhibitor for protein kinase C (PKC), and by MAPK kinase (MEK) inhibitor, PD98059, but were not affected by the tyrosine kinase inhibitor genistein.	Tetradecanoylphorbol Acetate	39-42	mitogen-activated protein kinase kinase 7	Homo sapiens	143-146
8660846-2	1996	We examined the topographical distribution of CD18 on human neutrophils in relation with shapes changes and movements induced by stimulation with 10(-8) M N-formylmethionyl-leucyl-phenylalanine (fMLP) and 10(-7) M phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	214-239	integrin subunit beta 2	Homo sapiens	46-50
8660846-2	1996	We examined the topographical distribution of CD18 on human neutrophils in relation with shapes changes and movements induced by stimulation with 10(-8) M N-formylmethionyl-leucyl-phenylalanine (fMLP) and 10(-7) M phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	241-244	integrin subunit beta 2	Homo sapiens	46-50
8663223-6	1996	Phorbol 12-myristate 13-acetate and phytohemagglutinin stimulation of Jurkat cells expressing Nef fails to produce the usual translocation of thetaPKC from the cytosol to the particulate fraction; translocation of betaPKC and epsilonPKC was unaffected.	Tetradecanoylphorbol Acetate	0-31	S100 calcium binding protein B	Homo sapiens	94-97
8660846-5	1996	Stimulation of neutrophils with 10(-8) M fMLP and 10(-7) M PMA for 10 min induced distinctive shape changes, i.e., polar and nonpolar ruffled shapes, and upregulation of the surface membrane content of CD18.	Tetradecanoylphorbol Acetate	59-62	integrin subunit beta 2	Homo sapiens	202-206
8663234-8	1996	We propose that 1,25-(OH)2D3 primes NB4 cells for 12-O-tetradecanoylphorbol-13-acetate-induced monocytic differentiation by increasing the expression of specific PKC isoforms and inducing the specific phosphorylation of key protein signaling intermediates.	Tetradecanoylphorbol Acetate	50-86	proline rich transmembrane protein 2	Homo sapiens	162-165
8663295-1	1996	Desensitization of p21(ras) after stimulation of cells by growth factors and phorbol 12-myristate 13-acetate (PMA) correlates with hyperphosphorylation of the guanine nucleotide exchange factor Son-of-sevenless (Sos) and its dissociation from the adaptor protein Grb2 (Cherniack, A., Klarlund, J. K., Conway, B. R., and Czech, M. P. (1995) J. Biol.	Tetradecanoylphorbol Acetate	77-108	growth factor receptor bound protein 2	Homo sapiens	263-267
8663295-1	1996	Desensitization of p21(ras) after stimulation of cells by growth factors and phorbol 12-myristate 13-acetate (PMA) correlates with hyperphosphorylation of the guanine nucleotide exchange factor Son-of-sevenless (Sos) and its dissociation from the adaptor protein Grb2 (Cherniack, A., Klarlund, J. K., Conway, B. R., and Czech, M. P. (1995) J. Biol.	Tetradecanoylphorbol Acetate	110-113	growth factor receptor bound protein 2	Homo sapiens	263-267
8712682-5	1996	TPA per se has no effect on [Ca2+]i, but potently reverses the NaF or ionomycin induced [Ca2+]i rise.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	63-66
8760139-4	1996	Compared with control cells, the rates of recovery from an acid load increased with PMA treatment, reaching a maximum at 15 min, and returned to control levels by 3 h. The PMA-stimulated changes in recovery rate were sensitive to H-7, a PKC inhibitor.	Tetradecanoylphorbol Acetate	84-87	proline rich transmembrane protein 2	Homo sapiens	237-240
8760139-4	1996	Compared with control cells, the rates of recovery from an acid load increased with PMA treatment, reaching a maximum at 15 min, and returned to control levels by 3 h. The PMA-stimulated changes in recovery rate were sensitive to H-7, a PKC inhibitor.	Tetradecanoylphorbol Acetate	172-175	proline rich transmembrane protein 2	Homo sapiens	237-240
8679225-3	1996	Phorbol myristate acetate, lipopolysaccharide, transforming growth factor-beta (TGF-beta), and tumor necrosis factor-alpha (TNF-alpha) increased uPA binding and plasminogen activation at the cell surface, with a greater maximal effect on fibrotic than on normal fibroblasts.	Tetradecanoylphorbol Acetate	0-25	plasminogen activator, urokinase	Homo sapiens	145-148
8712711-2	1996	The down-regulation of PKC-alpha and -beta in JCA-1 cells was correlated with the effects of TPA.	Tetradecanoylphorbol Acetate	93-96	protein kinase C alpha	Homo sapiens	23-42
8712682-6	1996	Also, TPA partially counteracted the acidification induced by NaF.	Tetradecanoylphorbol Acetate	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	62-65
8712682-7	1996	Both NaF and ionomycin per se had no effect on cell growth but partially counteracted TPA induced growth inhibition.	Tetradecanoylphorbol Acetate	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	5-8
8832110-1	1996	12-o-Tetradecanoylphorbol-13-Acetate (TPA) down-regulates the expression of the gene responsible for cystic fibrosis (CFTR).	Tetradecanoylphorbol Acetate	0-36	CF transmembrane conductance regulator	Homo sapiens	118-122
8763865-2	1996	The cells were stimulated under different oxygen and carbon dioxide concentrations in the presence and absence of the known TNF alpha inducer phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	142-173	tumor necrosis factor	Homo sapiens	124-133
8706259-4	1996	BoP strongly decreased the amount of E-cadherin protein and the level occurring in the membranes in both cell lines, whereas TPA caused a translocation of E-cadherin from the membrane towards the cytosol, without decreasing the total amount of E-cadherin present.	Tetradecanoylphorbol Acetate	125-128	cadherin 1	Mus musculus	155-165
8706259-4	1996	BoP strongly decreased the amount of E-cadherin protein and the level occurring in the membranes in both cell lines, whereas TPA caused a translocation of E-cadherin from the membrane towards the cytosol, without decreasing the total amount of E-cadherin present.	Tetradecanoylphorbol Acetate	125-128	cadherin 1	Mus musculus	155-165
8694775-4	1996	We show here that HT-29 cells or HT-29 M6 cells treated with PMA contain lower levels of functional E-cadherin, determined by analysing the association of this protein with the cytoskeleton.	Tetradecanoylphorbol Acetate	61-64	cadherin 1	Homo sapiens	100-110
8694775-8	1996	On the other hand an augmentation of c-src activity in HT-29 cells or HT-29 M6 cells treated with PMA was observed with respect to control HT-29 M6 cells.	Tetradecanoylphorbol Acetate	98-101	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	37-42
8832110-1	1996	12-o-Tetradecanoylphorbol-13-Acetate (TPA) down-regulates the expression of the gene responsible for cystic fibrosis (CFTR).	Tetradecanoylphorbol Acetate	38-41	CF transmembrane conductance regulator	Homo sapiens	118-122
8832110-2	1996	To understand the mechanism by which TPA down-regulates CFTR, we decided to study genes specifically induced by this phorbol ester in T84 human colon carcinoma cells, which highly express CFTR, using differential display.	Tetradecanoylphorbol Acetate	37-40	CF transmembrane conductance regulator	Homo sapiens	56-60
8764366-5	1996	U-73122 also caused a time-(15-120 min) and concentration-dependent inhibition (IC50 = 25-100 nM) of the N-formyl-methionyl-leucyl-phenylalanine-, TNF alpha- and PMA-elicited adhesion-dependent, oxidative burst, measured as hydrogen peroxide (H2O2) production, in PMN.	Tetradecanoylphorbol Acetate	162-165	tumor necrosis factor	Homo sapiens	147-156
8829112-4	1996	The PKC activator phorbol myristate acetate (PMA) dose-dependently inhibited both Ca2+ influx in resting cells and iCRAC, assessed by microfluorometry in fura-2-loaded monolayers, when added before or after 1 uM angiotensin II (AngII) (Ca2+ influx at 1 mM (Ca2+)e +278 +/- 56%/+80 +/- 8%, at 10 mM + 473 +/- 59%/+250 +/- 24% (Ca2+)e, -/+ PMA, respectively, P &lt; 0.05).	Tetradecanoylphorbol Acetate	18-43	angiotensinogen	Homo sapiens	212-226
8829112-4	1996	The PKC activator phorbol myristate acetate (PMA) dose-dependently inhibited both Ca2+ influx in resting cells and iCRAC, assessed by microfluorometry in fura-2-loaded monolayers, when added before or after 1 uM angiotensin II (AngII) (Ca2+ influx at 1 mM (Ca2+)e +278 +/- 56%/+80 +/- 8%, at 10 mM + 473 +/- 59%/+250 +/- 24% (Ca2+)e, -/+ PMA, respectively, P &lt; 0.05).	Tetradecanoylphorbol Acetate	18-43	angiotensinogen	Homo sapiens	228-233
8829112-4	1996	The PKC activator phorbol myristate acetate (PMA) dose-dependently inhibited both Ca2+ influx in resting cells and iCRAC, assessed by microfluorometry in fura-2-loaded monolayers, when added before or after 1 uM angiotensin II (AngII) (Ca2+ influx at 1 mM (Ca2+)e +278 +/- 56%/+80 +/- 8%, at 10 mM + 473 +/- 59%/+250 +/- 24% (Ca2+)e, -/+ PMA, respectively, P &lt; 0.05).	Tetradecanoylphorbol Acetate	45-48	angiotensinogen	Homo sapiens	212-226
8829112-4	1996	The PKC activator phorbol myristate acetate (PMA) dose-dependently inhibited both Ca2+ influx in resting cells and iCRAC, assessed by microfluorometry in fura-2-loaded monolayers, when added before or after 1 uM angiotensin II (AngII) (Ca2+ influx at 1 mM (Ca2+)e +278 +/- 56%/+80 +/- 8%, at 10 mM + 473 +/- 59%/+250 +/- 24% (Ca2+)e, -/+ PMA, respectively, P &lt; 0.05).	Tetradecanoylphorbol Acetate	45-48	angiotensinogen	Homo sapiens	228-233
8774354-5	1996	In addition to these phenotypical changes, IL-4 primed the phorbol-12-myristate-13-acetate (PMA)-induced luminol-dependent chemiluminescence response (LDCL) by normal human monocytes, this priming effect being abrogated in the presence of BW B70C.	Tetradecanoylphorbol Acetate	59-90	interleukin 4	Homo sapiens	43-47
8774354-5	1996	In addition to these phenotypical changes, IL-4 primed the phorbol-12-myristate-13-acetate (PMA)-induced luminol-dependent chemiluminescence response (LDCL) by normal human monocytes, this priming effect being abrogated in the presence of BW B70C.	Tetradecanoylphorbol Acetate	92-95	interleukin 4	Homo sapiens	43-47
8666983-2	1996	WHen the cells were treated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or retinoic acid, the level of Bcl-2 protein was increased compared with the control.	Tetradecanoylphorbol Acetate	33-69	BCL2 apoptosis regulator	Homo sapiens	107-112
8666983-2	1996	WHen the cells were treated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or retinoic acid, the level of Bcl-2 protein was increased compared with the control.	Tetradecanoylphorbol Acetate	71-74	BCL2 apoptosis regulator	Homo sapiens	107-112
8666999-2	1996	Angiotensin II-responsive elements are located within -54/+25-bp and -269/-55-bp promoter regions and were identified, respectively, as cyclic AMP (CRE)- and 12-O-tetradecanoylphorbol 13-acetate responsive element (TRE)-like sequences.	Tetradecanoylphorbol Acetate	158-194	angiotensinogen	Homo sapiens	0-14
8837013-0	1996	AP-1 regulation of the rat bone sialoprotein gene transcription is mediated through a TPA response element within a glucocorticoid response unit in the gene promoter.	Tetradecanoylphorbol Acetate	86-89	integrin-binding sialoprotein	Rattus norvegicus	27-44
8837013-2	1996	BSP expression is induced by glucocorticoids in association with osteoblast differentiation, and a glucocorticoid response element (GRE) overlapping a putative TRE (TPA, 12-O-tetradecanoyl-phorbol 13-acetate, response element) site has been identified in the rat BSP promoter (Ogata et al., 1995).	Tetradecanoylphorbol Acetate	165-168	integrin-binding sialoprotein	Rattus norvegicus	0-3
8837013-2	1996	BSP expression is induced by glucocorticoids in association with osteoblast differentiation, and a glucocorticoid response element (GRE) overlapping a putative TRE (TPA, 12-O-tetradecanoyl-phorbol 13-acetate, response element) site has been identified in the rat BSP promoter (Ogata et al., 1995).	Tetradecanoylphorbol Acetate	165-168	integrin-binding sialoprotein	Rattus norvegicus	263-266
8837013-2	1996	BSP expression is induced by glucocorticoids in association with osteoblast differentiation, and a glucocorticoid response element (GRE) overlapping a putative TRE (TPA, 12-O-tetradecanoyl-phorbol 13-acetate, response element) site has been identified in the rat BSP promoter (Ogata et al., 1995).	Tetradecanoylphorbol Acetate	170-207	integrin-binding sialoprotein	Rattus norvegicus	0-3
8837013-2	1996	BSP expression is induced by glucocorticoids in association with osteoblast differentiation, and a glucocorticoid response element (GRE) overlapping a putative TRE (TPA, 12-O-tetradecanoyl-phorbol 13-acetate, response element) site has been identified in the rat BSP promoter (Ogata et al., 1995).	Tetradecanoylphorbol Acetate	170-207	integrin-binding sialoprotein	Rattus norvegicus	263-266
8837013-5	1996	Rat BSP promoter constructs, transiently transfected into ROS 17/2.8 cells, were used to show that TPA suppressed transcription of a luciferase construct (-938/+60; pLUC6) that included the GRE/TRE, but not transcription of shorter contructs lacking this element.	Tetradecanoylphorbol Acetate	99-102	integrin-binding sialoprotein	Rattus norvegicus	4-7
8672532-5	1996	Phospholipase C activating agents (carbachol, CCK-8), adenylate cyclase activating agents (secretin, VIP), TPA and the calcium ionophore, A23187, all inhibited the binding of 125I-BH-SP and it was due to inhibition of ligand internalization with no change in surface bound parameters.	Tetradecanoylphorbol Acetate	107-110	tachykinin precursor 1	Homo sapiens	183-185
8690086-2	1996	In T84 human epithelia] cells 12-O-tetradecanoyl phorbol 13-acetate (TPA) caused persistent translocation of PKC delta to the membrane compartment and a 400% increase of PKC delta-mRNA after 24 h. In contrast, PKC alpha protein was completely downregulated and its mRNA was decreased to 60% of control levels after 24 h. This is the first report of PKC delta-mRNA upregulation by TPA which was previously only shown for PKCbeta.	Tetradecanoylphorbol Acetate	30-67	protein kinase C alpha	Homo sapiens	210-219
8690086-2	1996	In T84 human epithelia] cells 12-O-tetradecanoyl phorbol 13-acetate (TPA) caused persistent translocation of PKC delta to the membrane compartment and a 400% increase of PKC delta-mRNA after 24 h. In contrast, PKC alpha protein was completely downregulated and its mRNA was decreased to 60% of control levels after 24 h. This is the first report of PKC delta-mRNA upregulation by TPA which was previously only shown for PKCbeta.	Tetradecanoylphorbol Acetate	69-72	protein kinase C alpha	Homo sapiens	210-219
8660927-2	1996	p42 MAPK was localized by both immunoblot and kinase activity in both cytosol and nucleus and was rapidly activated, in both fractions, by fetal bovine serum and TPA.	Tetradecanoylphorbol Acetate	162-165	mitogen-activated protein kinase 1	Homo sapiens	0-8
8660927-3	1996	Downregulation of protein kinase C (PKC) by TPA inhibited stimulation of cytosolic p42 MAPK, but unexpectedly had no effect on stimulated p42 MAPK in the nucleus.	Tetradecanoylphorbol Acetate	44-47	mitogen-activated protein kinase 1	Homo sapiens	83-91
8841092-6	1996	The phosphorylation pattern of cx 43 prepared from H60- or CS52-exposed cells was different from that prepared from 12-O-tetradecanoylphobol-13-acetate (TPA)-exposed cells after 1 hr treatment.	Tetradecanoylphorbol Acetate	153-156	gap junction protein, alpha 1	Rattus norvegicus	31-36
8693291-2	1996	Phorbol-myristate-acetate (PMA), an activator of protein kinase C (PKC), also induced down-regulation of IL-2 responsiveness.	Tetradecanoylphorbol Acetate	0-25	interleukin 2	Homo sapiens	105-109
8693291-2	1996	Phorbol-myristate-acetate (PMA), an activator of protein kinase C (PKC), also induced down-regulation of IL-2 responsiveness.	Tetradecanoylphorbol Acetate	27-30	interleukin 2	Homo sapiens	105-109
8662755-2	1996	In both cell types, the NCX1 protein immunoprecipitated with a chicken anti-NCX1 antibody exhibited a significant basal phosphorylation that was further enhanced by treatment with endothelin-1, acidic fibroblast growth factor, phorbol 12-myristate 13-acetate, or okadaic acid.	Tetradecanoylphorbol Acetate	227-258	solute carrier family 8 member A1	Rattus norvegicus	24-28
8662755-2	1996	In both cell types, the NCX1 protein immunoprecipitated with a chicken anti-NCX1 antibody exhibited a significant basal phosphorylation that was further enhanced by treatment with endothelin-1, acidic fibroblast growth factor, phorbol 12-myristate 13-acetate, or okadaic acid.	Tetradecanoylphorbol Acetate	227-258	solute carrier family 8 member A1	Rattus norvegicus	76-80
8662755-8	1996	In NCX1-transfected cells, PKC down-regulation following prolonged exposure to phorbol 12-myristate 13-acetate abolished the acidic fibroblast growth factor-induced activation of exchange activity.	Tetradecanoylphorbol Acetate	79-110	solute carrier family 8 member A1	Rattus norvegicus	3-7
8638540-4	1996	In metastatic disease TATI and TPA values were significantly modified in patients with complete remission and TATI, TPA, and CA 19-9 in patients with partial remission and nonresponders.	Tetradecanoylphorbol Acetate	31-34	serine peptidase inhibitor Kazal type 1	Homo sapiens	110-114
8662925-2	1996	The NF-kappaB transcription factor is activated by a wide variety of stimuli, including phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	111-147	nuclear factor kappa B subunit 1	Homo sapiens	4-13
8662925-6	1996	Protein kinase C (PKC) is activated by 12-O-tetradecanoylphorbol-13-acetate and has been previously reported to phosphorylate IkappaB-alpha in vitro.	Tetradecanoylphorbol Acetate	39-75	NFKB inhibitor alpha	Homo sapiens	126-139
8805854-5	1996	Phorbol myristate acetate (PMA) induced macrophage-like differentiation and up-regulated the gamma c chain mRNA expression in THP-1 cells.	Tetradecanoylphorbol Acetate	0-25	GLI family zinc finger 2	Homo sapiens	126-131
8805854-5	1996	Phorbol myristate acetate (PMA) induced macrophage-like differentiation and up-regulated the gamma c chain mRNA expression in THP-1 cells.	Tetradecanoylphorbol Acetate	27-30	GLI family zinc finger 2	Homo sapiens	126-131
8652659-1	1996	The upstream region of the human NAD(P)H:quinone oxidoreductase (NQO1) gene contains a functional antioxidant responsive element (ARE) and an overlapping 12-O-tetradecanoyl-phorbol-13-acetate responsive element (TRE), with the sequence TGACTCAGCA.	Tetradecanoylphorbol Acetate	154-191	NAD(P)H quinone dehydrogenase 1	Homo sapiens	65-69
8679718-1	1996	A new anti-diabetic drug, pioglitazone, was tested as to whether it could ameliorate the decreased kinase activity of epidermal growth factor (EGF) receptor induced by phorbol ester (PMA) in A431 cells.	Tetradecanoylphorbol Acetate	183-186	epidermal growth factor receptor	Homo sapiens	118-156
8638540-4	1996	In metastatic disease TATI and TPA values were significantly modified in patients with complete remission and TATI, TPA, and CA 19-9 in patients with partial remission and nonresponders.	Tetradecanoylphorbol Acetate	116-119	serine peptidase inhibitor Kazal type 1	Homo sapiens	22-26
8764317-6	1996	With AVP in the bath, addition of phorbol 12-myristate 13-acetate (PMA, 10(-6) M) to the bath increased JHCO3 from 5.0 +/- 0.5 to 9.1 +/- 1.0 pmol.min-1.mm-1 (P &lt; 0.01).	Tetradecanoylphorbol Acetate	34-65	arginine vasopressin	Rattus norvegicus	5-8
8764317-8	1996	The effect of PMA to stimulate JHCO3 in the presence of AVP was abolished by pretreatment with pertussis toxin (2 x 10(-11) M).	Tetradecanoylphorbol Acetate	14-17	arginine vasopressin	Rattus norvegicus	56-59
24178685-7	1996	The inhibition of system B(0,+) by Ang II is mediated by protein kinase C (PKC) because it was mimicked by phorbol esters (phorbol 12-myristate 13-acetate) and was inhibited by staurosporine.	Tetradecanoylphorbol Acetate	123-154	angiotensinogen	Homo sapiens	35-41
8828810-6	1996	After 2 hours of treatment of cells with PMA, PKC alpha was predominantly detected in the PM and absent from the C. These results suggest that the signal transduction pathway of vasopressin in LLC-PK1 cells does not involve PKC alpha activation and translocation.	Tetradecanoylphorbol Acetate	41-44	vasopressin	Sus scrofa	178-189
8639843-4	1996	In highly purified CD4+ T cells, IFN-alpha upregulated IL-10 mRNA upon activation with phytohemagglutinin and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	110-135	CD4 molecule	Homo sapiens	19-22
8639843-4	1996	In highly purified CD4+ T cells, IFN-alpha upregulated IL-10 mRNA upon activation with phytohemagglutinin and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	110-135	interferon alpha 1	Homo sapiens	33-42
8703801-4	1996	When differentiation of MEG-01 was induced by 100 nm 12-O-tetradecanoyl-phorbol-13-acetate (TPA), rapid translocation from cytosol to membrane fraction and down-regulation of PKC alpha, -epsilon and -theta was observed in 1-2h.	Tetradecanoylphorbol Acetate	53-90	protein kinase C alpha	Homo sapiens	175-205
8780891-8	1996	A high concentration of TPA (1.6 microM) down regulated PKC-alpha and PKC-beta I almost completely and PKC-epsilon partially in wild-type SH-SY5Y and SH-SY5Y/trk cells.	Tetradecanoylphorbol Acetate	24-27	protein kinase C alpha	Homo sapiens	56-65
8780891-9	1996	Cells with down-regulated PKC-alpha and PKC-beta I after 1.6 microM TPA treatment still differentiated with growth factors.	Tetradecanoylphorbol Acetate	68-71	protein kinase C alpha	Homo sapiens	26-35
8780891-11	1996	The 1.6 microM TPA-induced down-regulation of PKC-epsilon was counteracted by bFGF and NGF but not by platelet-derived growth factor or IGF-I.	Tetradecanoylphorbol Acetate	15-18	fibroblast growth factor 2	Homo sapiens	78-82
8780895-7	1996	Upon incubation with differentiation inducers such as 12-O-tetradecanoylphorbol-13-acetate, lipopolysaccharide, a combination of interleukin (IL) 6 plus tumor necrosis factor (TNF) alpha, or IFN-gamma plus TNF-alpha, a pronounced increase in the amounts of Met mRNA and protein are seen in THP-1 cells.	Tetradecanoylphorbol Acetate	54-90	interleukin 6	Homo sapiens	129-147
8780895-7	1996	Upon incubation with differentiation inducers such as 12-O-tetradecanoylphorbol-13-acetate, lipopolysaccharide, a combination of interleukin (IL) 6 plus tumor necrosis factor (TNF) alpha, or IFN-gamma plus TNF-alpha, a pronounced increase in the amounts of Met mRNA and protein are seen in THP-1 cells.	Tetradecanoylphorbol Acetate	54-90	tumor necrosis factor	Homo sapiens	153-186
8828910-8	1996	Phorbol 12-myristate 13-acetate (PMA) counteracted the effect of H-7 on cAMP levels, which suggests that PKC is involved in the action of H-7.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	105-108
8828910-8	1996	Phorbol 12-myristate 13-acetate (PMA) counteracted the effect of H-7 on cAMP levels, which suggests that PKC is involved in the action of H-7.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	105-108
8800588-4	1996	Down-regulation of PKC by prolonged exposure to phorbol 12-myristate 13-acetate (PMA) completely inhibited the ability of TGF-beta 1 to potentiate epidermal growth factor-stimulated proliferation of VSMC.	Tetradecanoylphorbol Acetate	48-79	transforming growth factor, beta 1	Rattus norvegicus	122-132
8800588-4	1996	Down-regulation of PKC by prolonged exposure to phorbol 12-myristate 13-acetate (PMA) completely inhibited the ability of TGF-beta 1 to potentiate epidermal growth factor-stimulated proliferation of VSMC.	Tetradecanoylphorbol Acetate	81-84	transforming growth factor, beta 1	Rattus norvegicus	122-132
9099936-10	1996	Both spontaneous and up-regulated expression of ICAM-1, LFA-3 and VCAM-1 by IFN-gamma, IL-1beta or 12-o-tetradecanoyl phorbol 13-acetate (TPA) were markedly suppressed by clarithromycin in a dose-dependent manner at concentrations between 0.1 and 10 microg/ml.	Tetradecanoylphorbol Acetate	99-136	vascular cell adhesion molecule 1	Homo sapiens	66-72
9099936-10	1996	Both spontaneous and up-regulated expression of ICAM-1, LFA-3 and VCAM-1 by IFN-gamma, IL-1beta or 12-o-tetradecanoyl phorbol 13-acetate (TPA) were markedly suppressed by clarithromycin in a dose-dependent manner at concentrations between 0.1 and 10 microg/ml.	Tetradecanoylphorbol Acetate	138-141	vascular cell adhesion molecule 1	Homo sapiens	66-72
8804936-8	1996	On resting AMs, the surface expression of CD11b/CD18 was significantly higher (p &lt; 0.01) compared to resting BMs but did not increase further upon activation with fMLP, PMA or ionomycin.	Tetradecanoylphorbol Acetate	172-175	integrin subunit beta 2	Homo sapiens	48-52
8796380-6	1996	In contrast, stimulation of Kurloff cells for 18 h with ionomycin alone or in combination with TPA could induce the release of TNF-like factor(s) as observed by the TNF bioassay using L-929 TNF-sensitive target cells.	Tetradecanoylphorbol Acetate	95-98	tumor necrosis factor	Mus musculus	127-130
8796380-6	1996	In contrast, stimulation of Kurloff cells for 18 h with ionomycin alone or in combination with TPA could induce the release of TNF-like factor(s) as observed by the TNF bioassay using L-929 TNF-sensitive target cells.	Tetradecanoylphorbol Acetate	95-98	tumor necrosis factor	Mus musculus	165-168
8796380-6	1996	In contrast, stimulation of Kurloff cells for 18 h with ionomycin alone or in combination with TPA could induce the release of TNF-like factor(s) as observed by the TNF bioassay using L-929 TNF-sensitive target cells.	Tetradecanoylphorbol Acetate	95-98	tumor necrosis factor	Mus musculus	165-168
8764317-6	1996	With AVP in the bath, addition of phorbol 12-myristate 13-acetate (PMA, 10(-6) M) to the bath increased JHCO3 from 5.0 +/- 0.5 to 9.1 +/- 1.0 pmol.min-1.mm-1 (P &lt; 0.01).	Tetradecanoylphorbol Acetate	67-70	arginine vasopressin	Rattus norvegicus	5-8
8964847-8	1996	Whereas treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) reproduced the effect of AII on 3 beta-HSD expression, TPA failed to reproduce the effects of AII on P450c17 and P450scc and even resulted in a marked decrease in expression of P450c17.	Tetradecanoylphorbol Acetate	61-64	angiotensinogen	Homo sapiens	91-94
8632150-2	1996	NGF induced the accumulation of hypophosphorylated pRB within 30 min and the level peaked after 12 h. Viral Kiras, cyclic AMP (cAMP), and 12-O-tetradecanoylphorbol 13-acetate (TPA) also induced the hypophosphorylation of pRB, but epidermal growth factor and interleukin-6 did not.	Tetradecanoylphorbol Acetate	138-174	interleukin 6	Rattus norvegicus	258-271
8632179-7	1996	Relative to IL-1 beta, the greater increases in PGE2 production and cyclooxygenase activity caused by TPA correlated with a greater induction of PGHS-2 mRNA.	Tetradecanoylphorbol Acetate	102-105	interleukin 1 beta	Mus musculus	12-21
8964847-15	1996	These effects of AII cotreatment on expression of P450c17 and P450scc were reproduced by cotreatment with TPA (10 nmol/L), suggesting the involvement of protein kinase C in these attenuative responses.	Tetradecanoylphorbol Acetate	106-109	angiotensinogen	Homo sapiens	17-20
8964847-15	1996	These effects of AII cotreatment on expression of P450c17 and P450scc were reproduced by cotreatment with TPA (10 nmol/L), suggesting the involvement of protein kinase C in these attenuative responses.	Tetradecanoylphorbol Acetate	106-109	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	62-69
8632160-6	1996	Moreover, the inhibition of TPA-enhanced secretion was also apparent after only 2-h exposure to either PDBu or bryostatin-1, conditions that caused down-regulation of PKC-alpha, but not PKC-epsilon or zeta.	Tetradecanoylphorbol Acetate	28-31	protein kinase C alpha	Homo sapiens	167-176
8632160-7	1996	The PKC inhibitor Go-6976 (2 microM), which has been shown to inhibit selectively PKC-alpha and beta in vitro, also inhibited the TPA enhancement of carbachol- and (K+)-evoked NA release by &gt; 50%.	Tetradecanoylphorbol Acetate	130-133	protein kinase C alpha	Homo sapiens	4-7
8666821-5	1996	PMA, which activated the MAPK as potently as LPS, did not strongly activate MAPKAPK2, as assessed by hsp27 phosphorylation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase kinase 1	Mus musculus	25-29
8632160-8	1996	These data suggest that in SH-SY5Y cells, the ability of TPA to enhance carbachol- and (K+)-evoked NA secretion is due to activation of PKC-alpha.	Tetradecanoylphorbol Acetate	57-60	protein kinase C alpha	Homo sapiens	136-145
8661513-13	1996	At 60 hr after transfection, the cells exhibited PMA-stimulated Na influx (&gt;28%) indicating functional expression of NHE-2.	Tetradecanoylphorbol Acetate	49-52	solute carrier family 9 member A2	Sus scrofa	120-125
8648737-2	1996	We have found that the human T leukemia/lymphotropic virus type 1 viral protein Tax can also strongly costimulate expression of interleukin-2 (IL-2), IL-3, and granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA in T cells activated with the phorbol ester phorbol myristate acetate (PMA) and calcium ionophore, which can mimic activation through the antigen specific T-cell receptor.	Tetradecanoylphorbol Acetate	294-297	interleukin 2	Homo sapiens	128-141
8648737-2	1996	We have found that the human T leukemia/lymphotropic virus type 1 viral protein Tax can also strongly costimulate expression of interleukin-2 (IL-2), IL-3, and granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA in T cells activated with the phorbol ester phorbol myristate acetate (PMA) and calcium ionophore, which can mimic activation through the antigen specific T-cell receptor.	Tetradecanoylphorbol Acetate	267-292	interleukin 2	Homo sapiens	128-141
8648737-2	1996	We have found that the human T leukemia/lymphotropic virus type 1 viral protein Tax can also strongly costimulate expression of interleukin-2 (IL-2), IL-3, and granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA in T cells activated with the phorbol ester phorbol myristate acetate (PMA) and calcium ionophore, which can mimic activation through the antigen specific T-cell receptor.	Tetradecanoylphorbol Acetate	267-292	interleukin 2	Homo sapiens	143-147
8648737-2	1996	We have found that the human T leukemia/lymphotropic virus type 1 viral protein Tax can also strongly costimulate expression of interleukin-2 (IL-2), IL-3, and granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA in T cells activated with the phorbol ester phorbol myristate acetate (PMA) and calcium ionophore, which can mimic activation through the antigen specific T-cell receptor.	Tetradecanoylphorbol Acetate	294-297	interleukin 2	Homo sapiens	143-147
8661224-7	1996	Using human umbilical vein EC, we found that direct activation of PKC with the phorbol ester phorbol 12-myristate-13-acetate enhanced all three processes.	Tetradecanoylphorbol Acetate	93-124	proline rich transmembrane protein 2	Homo sapiens	66-69
8648737-3	1996	Reporter constructs also showed strong synergy between both stimuli and showed that Tax and the PMA-Ca2+ ionophore act through different regions of the IL-2 and GM-CSF genes.	Tetradecanoylphorbol Acetate	96-99	interleukin 2	Homo sapiens	152-156
8648737-6	1996	Tax protein mutants, however, showed that a pathway(s) other than NF-kappaB/rel induction could also cooperate with the PMA-Ca2+ ionophore to activate the GM-CSF and IL-2 genes.	Tetradecanoylphorbol Acetate	120-123	interleukin 2	Homo sapiens	166-170
8649402-7	1996	The ability of an interfering ERK-2 mutant to block phorbol myristate acetate and v-ras-dependent PAC-1 transcription indicates that mitogen-activated protein kinase activation is necessary for these stimuli to induce transcription of the PAC-1 gene in T cells.	Tetradecanoylphorbol Acetate	52-77	mitogen-activated protein kinase 1	Mus musculus	30-35
8836162-15	1996	These data demonstrate reciprocal regulation of ER and EGF-R gene expression by TPA, involving effects on transcriptional events, which appear to be mediated by sustained activation of PKC.	Tetradecanoylphorbol Acetate	80-83	epidermal growth factor receptor	Homo sapiens	55-60
8667655-4	1996	Megakaryocytic differentiation of K562 and HEL cells induced by phorbol 12-myristate 13-acetate is accompanied by down-regulation of tif mRNA expression.	Tetradecanoylphorbol Acetate	64-95	TYRO3 protein tyrosine kinase	Homo sapiens	133-136
8836162-2	1996	In addition, the tumour-promoting phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) inhibits ER and stimulates EGF-R expression in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	48-85	epidermal growth factor receptor	Homo sapiens	119-124
8836162-2	1996	In addition, the tumour-promoting phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) inhibits ER and stimulates EGF-R expression in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	87-90	epidermal growth factor receptor	Homo sapiens	119-124
8836162-3	1996	This study aimed to define further the potential mechanisms involved in the modulation of ER and EGF-R gene expression by TPA.	Tetradecanoylphorbol Acetate	122-125	epidermal growth factor receptor	Homo sapiens	97-102
8836162-9	1996	These data indicate a requirement for continuing protein synthesis for the TPA effect on EGF-R but not on ER mRNA levels.	Tetradecanoylphorbol Acetate	75-78	epidermal growth factor receptor	Homo sapiens	89-94
8836162-10	1996	Because the modulation of ER and EGF-R gene expression by TPA is likely to involve the protein kinase C (PKC) signal transduction pathway, the effects of other known activators of PKC were investigated.	Tetradecanoylphorbol Acetate	58-61	epidermal growth factor receptor	Homo sapiens	33-38
8662781-13	1996	C6-ceramide inhibited basal and PMA-induced phosphorylation of PKCalpha.	Tetradecanoylphorbol Acetate	32-35	protein kinase C alpha	Homo sapiens	63-71
8822588-10	1996	Beraprost completely negated uPA gene expression induced by phorbol myristate acetate, an activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	60-85	plasminogen activator, urokinase	Homo sapiens	29-32
8636415-4	1996	Fibrinogen Dusart, whose structural abnormality is in the COOH-terminal "alphaC" region of its Aalpha chain (Aalpha R554C-albumin), is associated with thrombophilia ("Dusart Syndrome"), and is characterized functionally by defective fibrin polymerization and clot structure, and reduced plasminogen binding and tPA-induced fibrinolysis.	Tetradecanoylphorbol Acetate	311-314	fibrinogen beta chain	Homo sapiens	0-10
8662781-3	1996	In Molt-4 cells, phorbol 12-myristate 13-acetate (PMA) induced retinoblastoma gene product (Rb) phosphorylation, and ceramide inhibited this effect, suggesting an inhibitory effect of ceramide on the protein kinase C (PKC) pathway, the primary target of PMA.	Tetradecanoylphorbol Acetate	17-48	protein kinase C alpha	Homo sapiens	218-221
8662781-3	1996	In Molt-4 cells, phorbol 12-myristate 13-acetate (PMA) induced retinoblastoma gene product (Rb) phosphorylation, and ceramide inhibited this effect, suggesting an inhibitory effect of ceramide on the protein kinase C (PKC) pathway, the primary target of PMA.	Tetradecanoylphorbol Acetate	50-53	protein kinase C alpha	Homo sapiens	218-221
8807638-8	1996	Culture of MIN6 cells overnight with TPA resulted in down-regulation of PKC-alpha (totally) and epsilon (partially), without significant change in the other isoforms.	Tetradecanoylphorbol Acetate	37-40	protein kinase C, alpha	Mus musculus	72-81
8662682-3	1996	Growth factors such as fetal calf serum, epidermal growth factor, phorbol 12-myristate 13-acetate, and lysophosphatidic acid stimulate the phosphorylation of serine residues in ABP-280 in quiescent 3Y1 cells.	Tetradecanoylphorbol Acetate	66-97	glutamate receptor interacting protein 2	Rattus norvegicus	177-180
8782859-4	1996	In this study, we analyzed the effects of phorbol 12-myristate 13-acetate (PMA), an activator of PKC, on the expression of CNTF-mRNA in cultured astrocytes from neonatal rat olfactory bulb.	Tetradecanoylphorbol Acetate	42-73	ciliary neurotrophic factor	Rattus norvegicus	123-127
8626698-9	1996	A causal link between PKC beta overexpression and ERK3 activation was established because 12-O-tetradecanoylphorbol-13-acetate treatment down-regulated both PKC and ERK3 activities in both PKC beta 1 transfectants.	Tetradecanoylphorbol Acetate	90-126	protein kinase C, alpha	Mus musculus	22-25
8723471-6	1996	Untreated THP-1 and phorbol myristate acetate-differentiated THP-1 were permissive for infection and multiplication of intracellular L. monocytogenes Hly+ (virulent variant).	Tetradecanoylphorbol Acetate	20-45	GLI family zinc finger 2	Homo sapiens	61-66
8738564-9	1996	We also found that YAP cells produced considerable amounts of TNF alpha, which was detected in the culture supernatant when the cells were treated with 1 ng/ml 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	160-196	tumor necrosis factor	Homo sapiens	62-71
8738564-9	1996	We also found that YAP cells produced considerable amounts of TNF alpha, which was detected in the culture supernatant when the cells were treated with 1 ng/ml 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	198-201	tumor necrosis factor	Homo sapiens	62-71
8645171-1	1996	Insulin, guanosine 5"-[gamma-thio]triphosphate (GTP[S] and phorbol 12-myristate 13-acetate (PMA) trigger the translocation of Gl UT4 (type 4 glucose transporter; insulin-sensitive glucose transporter) from an intracellular pool to the cell surface.	Tetradecanoylphorbol Acetate	59-90	insulin	Cricetulus griseus	162-169
8645171-1	1996	Insulin, guanosine 5"-[gamma-thio]triphosphate (GTP[S] and phorbol 12-myristate 13-acetate (PMA) trigger the translocation of Gl UT4 (type 4 glucose transporter; insulin-sensitive glucose transporter) from an intracellular pool to the cell surface.	Tetradecanoylphorbol Acetate	92-95	insulin	Cricetulus griseus	0-7
8645171-1	1996	Insulin, guanosine 5"-[gamma-thio]triphosphate (GTP[S] and phorbol 12-myristate 13-acetate (PMA) trigger the translocation of Gl UT4 (type 4 glucose transporter; insulin-sensitive glucose transporter) from an intracellular pool to the cell surface.	Tetradecanoylphorbol Acetate	92-95	insulin	Cricetulus griseus	162-169
8963726-10	1996	The phorbol ester TPA induced a rearrangement of PKC delta and a translocation of PKC alpha and epsilon to the nucleus.	Tetradecanoylphorbol Acetate	18-21	protein kinase C alpha	Homo sapiens	82-91
8963726-11	1996	Treatment of endothelial cells with TPA for 24 hours caused PKC alpha, delta, and epsilon to disappear, while PKC zeta was not influenced by TPA.	Tetradecanoylphorbol Acetate	36-39	protein kinase C alpha	Homo sapiens	60-69
8722631-9	1996	Steady-state concentrations of mRNA encoding PGF2 alpha-R were decreased (p &lt; 0.05) by PGF2 alpha and PMA treatment (4 and 12 h) but were increased (p &lt; 0.05) at 24 h after LH treatment.	Tetradecanoylphorbol Acetate	105-108	prostaglandin F receptor	Bos taurus	45-57
8616873-1	1996	Both TPA and A23187 dramatically enhanced MDA-MB-435 cell adhesion to type IV collagen (collagen IV), vitronectin, and, to some extent, fibronectin and laminin.	Tetradecanoylphorbol Acetate	5-8	fibronectin 1	Homo sapiens	136-147
8645143-1	1996	Incubation of HT-29 M6 cells with the phorbol ester phorbol 12-myristate 13-acetate (PMA) induces cell scattering, loss of cellular contacts and inactivation of E-cadherin.	Tetradecanoylphorbol Acetate	52-83	cadherin 1	Homo sapiens	161-171
8645143-1	1996	Incubation of HT-29 M6 cells with the phorbol ester phorbol 12-myristate 13-acetate (PMA) induces cell scattering, loss of cellular contacts and inactivation of E-cadherin.	Tetradecanoylphorbol Acetate	85-88	cadherin 1	Homo sapiens	161-171
8799329-3	1996	Activation of PKC by exposure to PMA or OAG inhibited albumin permeability in human AECs, but increased it in bovine AECs.	Tetradecanoylphorbol Acetate	33-36	proline rich transmembrane protein 2	Homo sapiens	14-17
8799329-4	1996	While the PKC inhibitor, staurosporine, did not itself influence endothelial permeability, it reduced the decrease or increase in permeability induced by exposure to PMA or OAG in human and bovine AECs, respectively.	Tetradecanoylphorbol Acetate	166-169	proline rich transmembrane protein 2	Homo sapiens	10-13
8722631-10	1996	In summary, 1) mRNA encoding PGF2 alpha-R was localized to large luteal cells; 2) concentrations of mRNA encoding PGF2 alpha-R did not vary during the estrous cycle; 3) treatment with PGF2 alpha or PMA to activate protein kinase C decreased concentrations of PGF2 alpha-R mRNA within 4 h of treatment; and 4) administration LH increased concentrations of mRNA encoding PGF2 alpha-R 24 h following injection.	Tetradecanoylphorbol Acetate	198-201	prostaglandin F receptor	Bos taurus	29-41
8722631-10	1996	In summary, 1) mRNA encoding PGF2 alpha-R was localized to large luteal cells; 2) concentrations of mRNA encoding PGF2 alpha-R did not vary during the estrous cycle; 3) treatment with PGF2 alpha or PMA to activate protein kinase C decreased concentrations of PGF2 alpha-R mRNA within 4 h of treatment; and 4) administration LH increased concentrations of mRNA encoding PGF2 alpha-R 24 h following injection.	Tetradecanoylphorbol Acetate	198-201	prostaglandin F receptor	Bos taurus	114-126
8722631-10	1996	In summary, 1) mRNA encoding PGF2 alpha-R was localized to large luteal cells; 2) concentrations of mRNA encoding PGF2 alpha-R did not vary during the estrous cycle; 3) treatment with PGF2 alpha or PMA to activate protein kinase C decreased concentrations of PGF2 alpha-R mRNA within 4 h of treatment; and 4) administration LH increased concentrations of mRNA encoding PGF2 alpha-R 24 h following injection.	Tetradecanoylphorbol Acetate	198-201	prostaglandin F receptor	Bos taurus	114-126
8722631-10	1996	In summary, 1) mRNA encoding PGF2 alpha-R was localized to large luteal cells; 2) concentrations of mRNA encoding PGF2 alpha-R did not vary during the estrous cycle; 3) treatment with PGF2 alpha or PMA to activate protein kinase C decreased concentrations of PGF2 alpha-R mRNA within 4 h of treatment; and 4) administration LH increased concentrations of mRNA encoding PGF2 alpha-R 24 h following injection.	Tetradecanoylphorbol Acetate	198-201	prostaglandin F receptor	Bos taurus	114-126
8782859-4	1996	In this study, we analyzed the effects of phorbol 12-myristate 13-acetate (PMA), an activator of PKC, on the expression of CNTF-mRNA in cultured astrocytes from neonatal rat olfactory bulb.	Tetradecanoylphorbol Acetate	75-78	ciliary neurotrophic factor	Rattus norvegicus	123-127
8620546-2	1996	In the current studies, IL-2 production by T cells from elderly (mean 78 years) and young (mean 37 years) humans was measured in cultures stimulated with PHA, PHA plus PMA, crosslinked anti-CD3 mAB OKT3 plus PMA, or PMA plus ionomycin.	Tetradecanoylphorbol Acetate	168-171	interleukin 2	Homo sapiens	24-28
8620546-2	1996	In the current studies, IL-2 production by T cells from elderly (mean 78 years) and young (mean 37 years) humans was measured in cultures stimulated with PHA, PHA plus PMA, crosslinked anti-CD3 mAB OKT3 plus PMA, or PMA plus ionomycin.	Tetradecanoylphorbol Acetate	208-211	interleukin 2	Homo sapiens	24-28
8620546-2	1996	In the current studies, IL-2 production by T cells from elderly (mean 78 years) and young (mean 37 years) humans was measured in cultures stimulated with PHA, PHA plus PMA, crosslinked anti-CD3 mAB OKT3 plus PMA, or PMA plus ionomycin.	Tetradecanoylphorbol Acetate	208-211	interleukin 2	Homo sapiens	24-28
8625537-9	1996	Similar but transient inhibition of most T-cell products (IL-2, IL-3, IL-4, IL-5, IL-10, TNF-beta and GM-CSF) was noted in the PMA/ionomycin-containing cultures.	Tetradecanoylphorbol Acetate	127-130	interleukin 2	Homo sapiens	58-62
8625537-9	1996	Similar but transient inhibition of most T-cell products (IL-2, IL-3, IL-4, IL-5, IL-10, TNF-beta and GM-CSF) was noted in the PMA/ionomycin-containing cultures.	Tetradecanoylphorbol Acetate	127-130	interleukin 4	Homo sapiens	70-74
8758495-4	1996	THP-1 cells were cultivated with a phorbol 12-myristate 13-acetate (PMA) for 24h prior to the infection.	Tetradecanoylphorbol Acetate	35-66	GLI family zinc finger 2	Homo sapiens	0-5
8613475-4	1996	TPA treatment of HT1080 cells induced the expression of interstitial collagenase (MMP-1) and increased the expression of gelatinase B (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), and MT-MMP, a membrane-bound activator of progelatinase A (proMMP-2), while MMP-2 and TIMP-2 expression were decreased.	Tetradecanoylphorbol Acetate	0-3	TIMP metallopeptidase inhibitor 1	Homo sapiens	143-183
8613475-4	1996	TPA treatment of HT1080 cells induced the expression of interstitial collagenase (MMP-1) and increased the expression of gelatinase B (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), and MT-MMP, a membrane-bound activator of progelatinase A (proMMP-2), while MMP-2 and TIMP-2 expression were decreased.	Tetradecanoylphorbol Acetate	0-3	TIMP metallopeptidase inhibitor 1	Homo sapiens	185-191
8647095-1	1996	The human tissue-type plasminogen activator gene (t-PA) is induced by the phorbol ester, phorbol 12-myristate 13-acetate (PMA), in HeLa cells.	Tetradecanoylphorbol Acetate	89-120	plasminogen activator, tissue type	Homo sapiens	10-48
8647095-1	1996	The human tissue-type plasminogen activator gene (t-PA) is induced by the phorbol ester, phorbol 12-myristate 13-acetate (PMA), in HeLa cells.	Tetradecanoylphorbol Acetate	89-120	plasminogen activator, tissue type	Homo sapiens	50-54
8647095-1	1996	The human tissue-type plasminogen activator gene (t-PA) is induced by the phorbol ester, phorbol 12-myristate 13-acetate (PMA), in HeLa cells.	Tetradecanoylphorbol Acetate	122-125	plasminogen activator, tissue type	Homo sapiens	10-48
8647095-1	1996	The human tissue-type plasminogen activator gene (t-PA) is induced by the phorbol ester, phorbol 12-myristate 13-acetate (PMA), in HeLa cells.	Tetradecanoylphorbol Acetate	122-125	plasminogen activator, tissue type	Homo sapiens	50-54
8707354-6	1996	Preincubation with anti-thrombin compounds such as hirudin and antithrombin-III-heparin almost completely suppressed the action of thrombin without affecting the actions of other stimuli including IL-1 beta, phorbol 12-myristate 13-acetate (PMA) and TRAP.	Tetradecanoylphorbol Acetate	208-239	coagulation factor II, thrombin	Homo sapiens	24-32
8707354-6	1996	Preincubation with anti-thrombin compounds such as hirudin and antithrombin-III-heparin almost completely suppressed the action of thrombin without affecting the actions of other stimuli including IL-1 beta, phorbol 12-myristate 13-acetate (PMA) and TRAP.	Tetradecanoylphorbol Acetate	241-244	coagulation factor II, thrombin	Homo sapiens	24-32
8707354-6	1996	Preincubation with anti-thrombin compounds such as hirudin and antithrombin-III-heparin almost completely suppressed the action of thrombin without affecting the actions of other stimuli including IL-1 beta, phorbol 12-myristate 13-acetate (PMA) and TRAP.	Tetradecanoylphorbol Acetate	241-244	coagulation factor II, thrombin	Homo sapiens	67-75
8613475-3	1996	While TPA treatment evoked a temporary increased expression of urokinase type PA (uPA), the production of both types of human plasminogen activator inhibitors (PAI) was induced and sustained over 12 h by TPA treatment shifting the protease-protease inhibitors balance in favor of the inhibitors.	Tetradecanoylphorbol Acetate	6-9	plasminogen activator, urokinase	Homo sapiens	63-80
8613475-3	1996	While TPA treatment evoked a temporary increased expression of urokinase type PA (uPA), the production of both types of human plasminogen activator inhibitors (PAI) was induced and sustained over 12 h by TPA treatment shifting the protease-protease inhibitors balance in favor of the inhibitors.	Tetradecanoylphorbol Acetate	6-9	plasminogen activator, urokinase	Homo sapiens	82-85
8613475-3	1996	While TPA treatment evoked a temporary increased expression of urokinase type PA (uPA), the production of both types of human plasminogen activator inhibitors (PAI) was induced and sustained over 12 h by TPA treatment shifting the protease-protease inhibitors balance in favor of the inhibitors.	Tetradecanoylphorbol Acetate	204-207	plasminogen activator, urokinase	Homo sapiens	63-80
8708540-6	1996	Both PACAP- and VIP-stimulated cAMP accumulation were potentiated by 4 beta-phorbol 12-myristate 13-acetate, an activator of protein kinase C. Two PACAP antagonists, PACAP 6-27 (3 x 10(-6) M) and PACAP 6-38 (3 x 10(-6) M), blocked PACAP- and VIP-stimulated cAMP accumulation.	Tetradecanoylphorbol Acetate	69-107	vasoactive intestinal peptide	Rattus norvegicus	16-19
8780004-0	1996	Ca2+/calmodulin-dependent transcriptional activation of neuropeptide Y gene induced by membrane depolarization: determination of Ca(2+)- and cyclic AMP/phorbol 12-myristate 13-acetate-responsive elements.	Tetradecanoylphorbol Acetate	152-183	neuropeptide Y	Rattus norvegicus	56-70
23194856-3	1996	An inhibitory effect could be observed at concentrations of &lt; 0.4 muM and in the presence of low concentrations of TPA (0.16 - 0.32 muM).	Tetradecanoylphorbol Acetate	118-121	latexin	Homo sapiens	135-138
8761968-2	1996	By Western blot analyses we have demonstrated that epidermal growth factor, interleukin 1 beta and phorbol 12-myristate 13-acetate all increase PGHS-2 amounts in amnion cells.	Tetradecanoylphorbol Acetate	99-130	prostaglandin-endoperoxide synthase 2	Homo sapiens	144-150
8758495-4	1996	THP-1 cells were cultivated with a phorbol 12-myristate 13-acetate (PMA) for 24h prior to the infection.	Tetradecanoylphorbol Acetate	68-71	GLI family zinc finger 2	Homo sapiens	0-5
8725724-3	1996	125I-fibrinogen bound specifically and saturably to either cell line, and specific fibrinogen binding increased upon stimulation of these cells with proinflammatory agents such as phorbol myristate (PMA), lipopolysaccharide (LPS) or tumor necrosis factor (TNF-alpha).	Tetradecanoylphorbol Acetate	199-202	fibrinogen beta chain	Homo sapiens	83-93
8633098-4	1996	The Paju cell line displays moderate expression of BCL2, the level of which increases in parallel with further neural differentiation induced by treatment with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	160-191	BCL2 apoptosis regulator	Homo sapiens	51-55
8614020-4	1996	While CAT (50,000 IU/rat) significantly reduced the biochemical changes induced by hydrogen peroxide produced by a glucose/glucose oxidase system, it markedly exacerbated the lesions induced by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	194-219	catalase	Rattus norvegicus	6-9
8626578-3	1996	Here we demonstrate that Alzheimer"s precursor protein (betaAPP) and A beta are present at low levels in normal lenses and increase in intact cultured monkey lenses treated with H2O2 or UV radiation (known cataractogenic agents), and with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	239-270	amyloid beta precursor protein	Homo sapiens	69-75
8630024-8	1996	However, flt-1, flt-4 and KDR transcript levels were enhanced following treatment with tetradecanoylphorbol acetate.	Tetradecanoylphorbol Acetate	87-115	fms related receptor tyrosine kinase 1	Homo sapiens	9-14
8603385-3	1996	The effects in general were small, the greatest being increases of 46-67% in Her2/neu mRNA levels in response to treatments with TPA or sodium saccharin following NMU treatments.	Tetradecanoylphorbol Acetate	129-132	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-85
8614020-4	1996	While CAT (50,000 IU/rat) significantly reduced the biochemical changes induced by hydrogen peroxide produced by a glucose/glucose oxidase system, it markedly exacerbated the lesions induced by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	221-224	catalase	Rattus norvegicus	6-9
8614020-6	1996	Parallel to the development of the lung damage, we noted a rapid reduction of CAT activity (80%) in the BALF of animals treated with PMA and CAT.	Tetradecanoylphorbol Acetate	133-136	catalase	Rattus norvegicus	78-81
8622872-2	1996	Cell type specific differences in p53-independent p21 expression and cell cycle arrest were found following treatment of human tumour cell lines with serum, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), or okadaic acid (OA).	Tetradecanoylphorbol Acetate	157-194	tumor protein p53	Homo sapiens	34-37
8605587-0	1996	Soluble tumor necrosis factor receptors inhibit phorbol myristate acetate and cytokine-induced HIV-1 expression chronically infected U1 cells.	Tetradecanoylphorbol Acetate	48-73	tumor necrosis factor	Homo sapiens	8-29
8605587-5	1996	Addition of r-hTBP-1 to U1 cells during the last 4 h of a 24 h incubation with PMA still inhibited p24 antigen production by 15%.	Tetradecanoylphorbol Acetate	79-82	transmembrane p24 trafficking protein 2	Homo sapiens	99-102
8612684-5	1996	Phorbol ester (PMA), a PKC activator, induced stromelysin gene expression, an effect enhanced by the addition of IL-1 beta.	Tetradecanoylphorbol Acetate	15-18	interleukin 1 beta	Homo sapiens	113-122
8615822-1	1996	We examined the role of protein kinase C alpha (PKC alpha ) in the stimulation of DNA synthesis of Swiss 3T3 cells induced by bombesin, platelet-derived growth factor (PDGF) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	178-209	protein kinase C, alpha	Mus musculus	24-46
8615822-1	1996	We examined the role of protein kinase C alpha (PKC alpha ) in the stimulation of DNA synthesis of Swiss 3T3 cells induced by bombesin, platelet-derived growth factor (PDGF) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	178-209	protein kinase C, alpha	Mus musculus	48-57
8622872-2	1996	Cell type specific differences in p53-independent p21 expression and cell cycle arrest were found following treatment of human tumour cell lines with serum, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), or okadaic acid (OA).	Tetradecanoylphorbol Acetate	157-194	cyclin dependent kinase inhibitor 1A	Homo sapiens	50-53
8622872-2	1996	Cell type specific differences in p53-independent p21 expression and cell cycle arrest were found following treatment of human tumour cell lines with serum, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), or okadaic acid (OA).	Tetradecanoylphorbol Acetate	196-199	tumor protein p53	Homo sapiens	34-37
8626526-5	1996	The cell-permeable ceramide analogue N-acetylsphingosine and the phorbol ester phorbol 12-myristate 13-acetate (PMA) both induced the phosphorylation and increased the activities of the protein kinase JNK1 and the transcription factor ATF2.	Tetradecanoylphorbol Acetate	79-110	activating transcription factor 2	Rattus norvegicus	235-239
8626526-5	1996	The cell-permeable ceramide analogue N-acetylsphingosine and the phorbol ester phorbol 12-myristate 13-acetate (PMA) both induced the phosphorylation and increased the activities of the protein kinase JNK1 and the transcription factor ATF2.	Tetradecanoylphorbol Acetate	112-115	activating transcription factor 2	Rattus norvegicus	235-239
8622872-2	1996	Cell type specific differences in p53-independent p21 expression and cell cycle arrest were found following treatment of human tumour cell lines with serum, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), or okadaic acid (OA).	Tetradecanoylphorbol Acetate	196-199	cyclin dependent kinase inhibitor 1A	Homo sapiens	50-53
8622872-3	1996	TPA induced p21 in ML1, K562 and HL60 leukemia cells, whereas OA induced p21 in SW480 and GM4723 carcinoma cells as well as in leukemic cells.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	12-15
8622872-4	1996	In addition, TPA- and serum- but not OA-induced cell cycle arrest was reversed upon return of p21 to basal levels.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	94-97
8660351-3	1996	Instead PMA-induced megakaryocytic differentiation of K562 cells was inhibited by the pretreatment of pyrrolidine dithiocarbamate, a specific nuclear factor kappaB (NF-kappaB) inhibitor.	Tetradecanoylphorbol Acetate	8-11	nuclear factor kappa B subunit 1	Homo sapiens	157-163
8622872-6	1996	The results showed a complete inhibition of p21 mRNA and protein induction by TPA or adriamycin but little effect on p21 mRNA induced by OA in the presence of AMD.	Tetradecanoylphorbol Acetate	78-81	cyclin dependent kinase inhibitor 1A	Homo sapiens	44-47
8660351-3	1996	Instead PMA-induced megakaryocytic differentiation of K562 cells was inhibited by the pretreatment of pyrrolidine dithiocarbamate, a specific nuclear factor kappaB (NF-kappaB) inhibitor.	Tetradecanoylphorbol Acetate	8-11	nuclear factor kappa B subunit 1	Homo sapiens	165-174
8622872-7	1996	These results suggested that TPA-induced p21 expression requires transcription initiation, while a post-transcriptional mechanism may be involved in OA-induction as well.	Tetradecanoylphorbol Acetate	29-32	cyclin dependent kinase inhibitor 1A	Homo sapiens	41-44
8660351-4	1996	Taken together, these results suggest that the activation of NF-kappaB rather than that of MAPK might be involved in the PMA-induced megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	121-124	nuclear factor kappa B subunit 1	Homo sapiens	61-70
8622872-8	1996	Transient transfection assays with p21 promoter-luciferase reporters and TPA or OA treatment further confirmed that TPA, and to a lesser extent, OA, initiated transcription of p21.	Tetradecanoylphorbol Acetate	73-76	cyclin dependent kinase inhibitor 1A	Homo sapiens	176-179
8622872-8	1996	Transient transfection assays with p21 promoter-luciferase reporters and TPA or OA treatment further confirmed that TPA, and to a lesser extent, OA, initiated transcription of p21.	Tetradecanoylphorbol Acetate	116-119	cyclin dependent kinase inhibitor 1A	Homo sapiens	35-38
8622872-8	1996	Transient transfection assays with p21 promoter-luciferase reporters and TPA or OA treatment further confirmed that TPA, and to a lesser extent, OA, initiated transcription of p21.	Tetradecanoylphorbol Acetate	116-119	cyclin dependent kinase inhibitor 1A	Homo sapiens	176-179
8622872-9	1996	Finally, the protein kinase C inhibitor, staurosporine, was found to interfere with p21 induction and prevent cell cycle arrest following treatment with TPA but not OA, suggesting a requirement for PKC in TPA activation of p21 expression.	Tetradecanoylphorbol Acetate	153-156	cyclin dependent kinase inhibitor 1A	Homo sapiens	223-226
8622872-9	1996	Finally, the protein kinase C inhibitor, staurosporine, was found to interfere with p21 induction and prevent cell cycle arrest following treatment with TPA but not OA, suggesting a requirement for PKC in TPA activation of p21 expression.	Tetradecanoylphorbol Acetate	205-208	cyclin dependent kinase inhibitor 1A	Homo sapiens	84-87
8622872-9	1996	Finally, the protein kinase C inhibitor, staurosporine, was found to interfere with p21 induction and prevent cell cycle arrest following treatment with TPA but not OA, suggesting a requirement for PKC in TPA activation of p21 expression.	Tetradecanoylphorbol Acetate	205-208	cyclin dependent kinase inhibitor 1A	Homo sapiens	223-226
8630101-8	1996	In rabbit articular chondrocyte cultures, administration of transforming growth factor beta 1 (TGF beta 1) and bone morphogenetic protein 2 increased SPARC levels at 24-48 hours, whereas interleukin-lbeta (IL-1 beta), IL-1 alpha, tumor necrosis factor alpha, lipopolysaccharide, phorbol myristate acetate, basic fibroblast growth factor, and dexamethasone decreased SPARC levels at 24-72 hours.	Tetradecanoylphorbol Acetate	279-304	LOW QUALITY PROTEIN: transforming growth factor beta-1	Oryctolagus cuniculus	60-93
8728040-9	1996	Because the above pathways exert an effect on the expression or activation of activation protein (AP)-1 components, we confirm that OSM and bFGF induce TPA response element (TRE)-luciferase activity synergistically.	Tetradecanoylphorbol Acetate	152-155	fibroblast growth factor 2	Homo sapiens	140-144
8928811-4	1996	Inhibition of protein kinase C (PKC) activity blocked these effects of TPA.	Tetradecanoylphorbol Acetate	71-74	protein kinase C, alpha	Mus musculus	32-35
8928811-10	1996	Translocation of PKC-alpha to the membrane, followed by its calpain-induced downmodulation, is apparently required for the reversible pattern of cytoskeletal changes caused by TPA.	Tetradecanoylphorbol Acetate	176-179	protein kinase C, alpha	Mus musculus	17-26
8630101-8	1996	In rabbit articular chondrocyte cultures, administration of transforming growth factor beta 1 (TGF beta 1) and bone morphogenetic protein 2 increased SPARC levels at 24-48 hours, whereas interleukin-lbeta (IL-1 beta), IL-1 alpha, tumor necrosis factor alpha, lipopolysaccharide, phorbol myristate acetate, basic fibroblast growth factor, and dexamethasone decreased SPARC levels at 24-72 hours.	Tetradecanoylphorbol Acetate	279-304	transforming growth factor beta 1	Homo sapiens	95-105
9052983-7	1996	TPA-resistant LNCaP cells in the continuous presence of TPA, or 24 h after removal of TPA, had down-regulated PKC alpha and remained resistant to re-addition of TPA.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	110-119
8635212-7	1996	Pretreatment with phorbol 12-myristate 13-acetate (PMA) to downregulate protein kinase C (PKC) attenuates thrombin- and TRAP-dependent activation of MAPK, although small and equivalent effects of thrombin and TRAP to stimulate MAPK persist in PMA-pretreated cells.	Tetradecanoylphorbol Acetate	18-49	coagulation factor II	Rattus norvegicus	106-114
9052983-1	1996	Others have reported that the phorbol ester 12-0-tetradecanoylphorbol-13-acetate (TPA), an activator and down-regulator of most protein kinase C (PKC) isozymes, can induce apoptotic cell death of androgen-sensitive LNCaP but not androgen-insensitive PC-3 or DU 145 human prostate cancer cells.	Tetradecanoylphorbol Acetate	82-85	protein kinase C alpha	Homo sapiens	146-149
9052983-6	1996	Incubation with TPA for 6 h or more induced 95% inhibition of cell growth, a transient 12-fold increase and 5-fold decrease in PKC alpha and mu mRNA levels, respectively, and prolonged translocation of PKC alpha to non-nuclear membranes in unmodified LNCaP cells and in TPA-resistant LNCaP cells from which TPA had been removed for 10 days.	Tetradecanoylphorbol Acetate	16-19	protein kinase C alpha	Homo sapiens	127-136
8730730-4	1996	Oxidant production by FMLP- and calcium ionophore (A23187)-activated neutrophils was particularly sensitive to inhibition by low concentrations (0.3-3 microM) of salmeterol, while the responses of phorbol myristate acetate- and opsonised zymosan-stimulated cells were affected only by higher concentrations (3-50 microM) of the drug.	Tetradecanoylphorbol Acetate	197-222	formyl peptide receptor 1	Homo sapiens	22-26
8635212-7	1996	Pretreatment with phorbol 12-myristate 13-acetate (PMA) to downregulate protein kinase C (PKC) attenuates thrombin- and TRAP-dependent activation of MAPK, although small and equivalent effects of thrombin and TRAP to stimulate MAPK persist in PMA-pretreated cells.	Tetradecanoylphorbol Acetate	18-49	coagulation factor II	Rattus norvegicus	196-204
8635212-7	1996	Pretreatment with phorbol 12-myristate 13-acetate (PMA) to downregulate protein kinase C (PKC) attenuates thrombin- and TRAP-dependent activation of MAPK, although small and equivalent effects of thrombin and TRAP to stimulate MAPK persist in PMA-pretreated cells.	Tetradecanoylphorbol Acetate	51-54	coagulation factor II	Rattus norvegicus	106-114
8635212-7	1996	Pretreatment with phorbol 12-myristate 13-acetate (PMA) to downregulate protein kinase C (PKC) attenuates thrombin- and TRAP-dependent activation of MAPK, although small and equivalent effects of thrombin and TRAP to stimulate MAPK persist in PMA-pretreated cells.	Tetradecanoylphorbol Acetate	51-54	coagulation factor II	Rattus norvegicus	196-204
9052983-6	1996	Incubation with TPA for 6 h or more induced 95% inhibition of cell growth, a transient 12-fold increase and 5-fold decrease in PKC alpha and mu mRNA levels, respectively, and prolonged translocation of PKC alpha to non-nuclear membranes in unmodified LNCaP cells and in TPA-resistant LNCaP cells from which TPA had been removed for 10 days.	Tetradecanoylphorbol Acetate	16-19	protein kinase C alpha	Homo sapiens	202-211
9052983-6	1996	Incubation with TPA for 6 h or more induced 95% inhibition of cell growth, a transient 12-fold increase and 5-fold decrease in PKC alpha and mu mRNA levels, respectively, and prolonged translocation of PKC alpha to non-nuclear membranes in unmodified LNCaP cells and in TPA-resistant LNCaP cells from which TPA had been removed for 10 days.	Tetradecanoylphorbol Acetate	270-273	protein kinase C alpha	Homo sapiens	202-211
9052983-6	1996	Incubation with TPA for 6 h or more induced 95% inhibition of cell growth, a transient 12-fold increase and 5-fold decrease in PKC alpha and mu mRNA levels, respectively, and prolonged translocation of PKC alpha to non-nuclear membranes in unmodified LNCaP cells and in TPA-resistant LNCaP cells from which TPA had been removed for 10 days.	Tetradecanoylphorbol Acetate	270-273	protein kinase C alpha	Homo sapiens	202-211
9052983-7	1996	TPA-resistant LNCaP cells in the continuous presence of TPA, or 24 h after removal of TPA, had down-regulated PKC alpha and remained resistant to re-addition of TPA.	Tetradecanoylphorbol Acetate	56-59	protein kinase C alpha	Homo sapiens	110-119
9052983-7	1996	TPA-resistant LNCaP cells in the continuous presence of TPA, or 24 h after removal of TPA, had down-regulated PKC alpha and remained resistant to re-addition of TPA.	Tetradecanoylphorbol Acetate	56-59	protein kinase C alpha	Homo sapiens	110-119
9052983-7	1996	TPA-resistant LNCaP cells in the continuous presence of TPA, or 24 h after removal of TPA, had down-regulated PKC alpha and remained resistant to re-addition of TPA.	Tetradecanoylphorbol Acetate	56-59	protein kinase C alpha	Homo sapiens	110-119
9052991-5	1996	In K562 and OCI/AML-3 cells, the levels of the four NFI mRNAs and the mobility of NFI-DNA complexes present in nuclear extracts changed during treatment with TPA.	Tetradecanoylphorbol Acetate	158-161	nuclear factor I C	Homo sapiens	52-55
9052991-5	1996	In K562 and OCI/AML-3 cells, the levels of the four NFI mRNAs and the mobility of NFI-DNA complexes present in nuclear extracts changed during treatment with TPA.	Tetradecanoylphorbol Acetate	158-161	nuclear factor I C	Homo sapiens	82-85
9052991-6	1996	The TPA-induced change in mobility of NFI-DNA complexes in OCI/AML-3 cells was blocked by an inhibitor of protein synthesis, cycloheximide.	Tetradecanoylphorbol Acetate	4-7	nuclear factor I C	Homo sapiens	38-41
8771559-9	1996	In protein kinase C-downregulated cells pretreated with PMA for 24 h, the stimulatory effect of PACAP on TH and DBH gene expression was diminished.	Tetradecanoylphorbol Acetate	56-59	tyrosine hydroxylase	Homo sapiens	105-107
8625888-19	1996	Interestingly, SF-1 not only regulates differentiation, but also inhibits TPA-induced GC mitosis.	Tetradecanoylphorbol Acetate	74-77	splicing factor 1	Rattus norvegicus	15-19
8728016-2	1996	The basal O2- release and the phorbol myristate acetate (PMA)-induced O2- release were not significantly different in the two neutrophil populations, while in response to formyl-methionyl-leucyl-phenylalanine (fMLP) the exudate cells showed an activity that was two fold higher than that of blood cells.	Tetradecanoylphorbol Acetate	30-55	formyl peptide receptor 1	Homo sapiens	210-214
8617999-5	1996	Treatment of mouse skin with 12-0-tetradecanoyl-phorbol-13-acetate (TPA) produced a large increase in cornifin-alpha/SPRR1 protein and mRNA.	Tetradecanoylphorbol Acetate	68-71	small proline-rich protein 1A	Mus musculus	102-116
8617999-6	1996	Immunohistochemical localization of cornifin-alpha/SPRR1 in TPA-treated skin indicated that cornifin-alpha/SPRR1 was increased in the suprabasal epidermis but not in the follicle.	Tetradecanoylphorbol Acetate	60-63	small proline-rich protein 1A	Mus musculus	36-50
8617999-6	1996	Immunohistochemical localization of cornifin-alpha/SPRR1 in TPA-treated skin indicated that cornifin-alpha/SPRR1 was increased in the suprabasal epidermis but not in the follicle.	Tetradecanoylphorbol Acetate	60-63	small proline-rich protein 1A	Mus musculus	92-106
8618003-4	1996	On Northern blot analysis, the baseline expression of the 1.2-kb POMC transcript was upregulated by ultraviolet radiation (UVR) or by stimulation with interleukin-1 alpha (IL-1 alpha) or phorbol 12-tetradecanoate 13-acetate (TPA).	Tetradecanoylphorbol Acetate	187-223	proopiomelanocortin	Homo sapiens	65-69
8618003-4	1996	On Northern blot analysis, the baseline expression of the 1.2-kb POMC transcript was upregulated by ultraviolet radiation (UVR) or by stimulation with interleukin-1 alpha (IL-1 alpha) or phorbol 12-tetradecanoate 13-acetate (TPA).	Tetradecanoylphorbol Acetate	225-228	proopiomelanocortin	Homo sapiens	65-69
8618003-7	1996	Within 36 h after TPA stimulation, beta-endorphin became undetectable in cell extracts, coinciding with an increase of beta-endorphin-immunoreactive protein in the culture medium.	Tetradecanoylphorbol Acetate	18-21	proopiomelanocortin	Homo sapiens	35-49
8618003-8	1996	Our data establish that keratinocytes synthesize POMC protein as well as its derivatives beta LPH and beta-endorphin, and that this process is modulated by TPA, IL-1A, and UVR.	Tetradecanoylphorbol Acetate	156-159	proopiomelanocortin	Homo sapiens	49-53
8927510-7	1996	However, treatment with the proinflammatory cytokine interleukin 1 "beta" (IL-1 "beta") or phorbol 12-myristate-acetate (PMA) led to a marked increase in TNF "alpha" mRNA levels.	Tetradecanoylphorbol Acetate	121-124	tumor necrosis factor	Homo sapiens	154-165
8726942-9	1996	Compared to normal controls, rabbits challenged with PMA alone developed arterial acidosis, hypercapnia and hypoxaemia, accompanied by significant rise in plasma IL-8 concentration.	Tetradecanoylphorbol Acetate	53-56	interleukin-8	Oryctolagus cuniculus	162-166
8613704-1	1996	Human THP-1 leukemia cells differentiate along the monocytic lineage following exposure to phorbol-12-myristate-13-acetate (PMA) or 1,25-dihydroxyvitamin D3 (VD3).	Tetradecanoylphorbol Acetate	91-122	GLI family zinc finger 2	Homo sapiens	6-11
8613704-1	1996	Human THP-1 leukemia cells differentiate along the monocytic lineage following exposure to phorbol-12-myristate-13-acetate (PMA) or 1,25-dihydroxyvitamin D3 (VD3).	Tetradecanoylphorbol Acetate	124-127	GLI family zinc finger 2	Homo sapiens	6-11
8613704-5	1996	Lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF-alpha) release was higher in PMA-treated cells.	Tetradecanoylphorbol Acetate	98-101	tumor necrosis factor	Homo sapiens	65-74
8657115-6	1996	Moreover, PMA caused the dephosphorylation of Tyk2 but not of Jak1, which was activated by IFN.	Tetradecanoylphorbol Acetate	10-13	interferon alpha 1	Homo sapiens	91-94
8631809-5	1996	In transient transfection assays, both multicopy NFAT- and IL-2 promoter-beta-galactosidase reporter gene constructs could be activated by phorbol 12-myristate 13-acetate (PMA)/alpha-CD28 stimulation, and this activation was resistant to CsA.	Tetradecanoylphorbol Acetate	139-170	interleukin 2	Homo sapiens	59-63
8631745-11	1996	It appears that cleavage of alpha6 is required to generate the proper conformation in alpha6 that enables affinity modulation of the alpha6A-beta1 receptor by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	159-190	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	141-146
8631819-6	1996	Binding of aLDL to phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages was suppressed by TNF-alpha in a dose-dependent manner.	Tetradecanoylphorbol Acetate	19-50	GLI family zinc finger 2	Homo sapiens	72-77
8631809-5	1996	In transient transfection assays, both multicopy NFAT- and IL-2 promoter-beta-galactosidase reporter gene constructs could be activated by phorbol 12-myristate 13-acetate (PMA)/alpha-CD28 stimulation, and this activation was resistant to CsA.	Tetradecanoylphorbol Acetate	172-175	interleukin 2	Homo sapiens	59-63
8631819-6	1996	Binding of aLDL to phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages was suppressed by TNF-alpha in a dose-dependent manner.	Tetradecanoylphorbol Acetate	19-50	tumor necrosis factor	Homo sapiens	108-117
8631819-6	1996	Binding of aLDL to phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages was suppressed by TNF-alpha in a dose-dependent manner.	Tetradecanoylphorbol Acetate	52-55	GLI family zinc finger 2	Homo sapiens	72-77
8737381-2	1996	In cells incubated for 24 h, TPA inhibited follicle-stimulating hormone (FSH)-stimulated cytochrome P450 cholesterol side-chain cleavage (P450scc) mRNA accumulation.	Tetradecanoylphorbol Acetate	29-32	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	138-145
8631819-6	1996	Binding of aLDL to phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages was suppressed by TNF-alpha in a dose-dependent manner.	Tetradecanoylphorbol Acetate	52-55	tumor necrosis factor	Homo sapiens	108-117
8737382-5	1996	Phorbol-12-myristate-13-acetate (PMA) also strongly induced ODC activity in a transient manner, and additively to the effect of IGF-1.	Tetradecanoylphorbol Acetate	0-31	insulin like growth factor 1	Homo sapiens	128-133
8737382-5	1996	Phorbol-12-myristate-13-acetate (PMA) also strongly induced ODC activity in a transient manner, and additively to the effect of IGF-1.	Tetradecanoylphorbol Acetate	33-36	insulin like growth factor 1	Homo sapiens	128-133
8737381-3	1996	In contrast, at 4 h, TPA increased P450scc mRNA concentration in the absence and presence of FSH or 8-bromo-cAMP; in addition, TPA augmented FSH-stimulated cAMP accumulation.	Tetradecanoylphorbol Acetate	21-24	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	35-42
8737381-7	1996	However, TPA no longer augmented the FSH- or 8-bromo-cAMP-stimulated P450scc mRNA accumulation when IBMX was present.	Tetradecanoylphorbol Acetate	9-12	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	69-76
8649827-5	1996	In cultured ovarian cancer cells, c-jun and jun-B expression is inducible by serum and TPA and is therefore not constitutive.	Tetradecanoylphorbol Acetate	87-90	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	44-49
8636154-3	1996	We have investigated changes in activity and expression of both IRP1 and IRP2 during phorbol 12-myristate 13-acetate (PMA)-induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	85-116	iron responsive element binding protein 2	Homo sapiens	73-77
8636154-3	1996	We have investigated changes in activity and expression of both IRP1 and IRP2 during phorbol 12-myristate 13-acetate (PMA)-induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	118-121	iron responsive element binding protein 2	Homo sapiens	73-77
8626394-4	1996	Phosphorylation of p105 in Jurkat cells treated with phorbol 12-myristate 13-acetate/ionomycin or with okadaic acid, another activator of NF-kappaB, is correlated with an increase in proteolytic processing to p5O.	Tetradecanoylphorbol Acetate	53-84	nuclear factor kappa B subunit 1	Homo sapiens	19-23
8703583-3	1996	Scatchard analysis of 125I-labeled IGF-I to FLG 29.1 cells revealed the presence of a single high affinity binding site in both untreated and TPA-treated cells with a similar Kd value (0.3 +/- 0.2 nmol/L and 0.4 +/- 0.1 nmol/L, respectively).	Tetradecanoylphorbol Acetate	142-145	insulin like growth factor 1	Homo sapiens	35-40
8626394-4	1996	Phosphorylation of p105 in Jurkat cells treated with phorbol 12-myristate 13-acetate/ionomycin or with okadaic acid, another activator of NF-kappaB, is correlated with an increase in proteolytic processing to p5O.	Tetradecanoylphorbol Acetate	53-84	nuclear factor kappa B subunit 1	Homo sapiens	138-147
8626394-5	1996	Intact PEST sequences are required for the phorbol 12-myristate 13-acetate/ionomycin-induced p105 processing, as a 68-amino acid C-terminal deletion abolishes the response to stimulation.	Tetradecanoylphorbol Acetate	43-74	nuclear factor kappa B subunit 1	Homo sapiens	93-97
8630547-7	1996	Similarly, BAL-derived cells displayed significantly increased phorbol myristate acetate-stimulated release of superoxide anion (8.8 +/- 1.3 versus 4.5 +/- 0.7 nmol/5 x 10 5 cells/h; p&lt;0.01) for the oldest versus youngest subject group, and mean BAL IL-6 concentrations were significantly elevated in the oldest age group (0.86 +/- 0.13 ng/ml) compared with the youngest age group (0.53 +/- 0.03 ng/ml; p&lt;0.01).	Tetradecanoylphorbol Acetate	63-88	interleukin 6	Homo sapiens	253-257
8616013-2	1996	PKC activity was analysed using a serine substituted specific peptide, which enabled us to evaluate the whole catalytic activity in the pluripotent haemopoietic HEL cell line treated with 10(-7)M phorbol myristate acetate (PMA) or haemin.	Tetradecanoylphorbol Acetate	196-221	protein kinase C alpha	Homo sapiens	0-3
8616013-2	1996	PKC activity was analysed using a serine substituted specific peptide, which enabled us to evaluate the whole catalytic activity in the pluripotent haemopoietic HEL cell line treated with 10(-7)M phorbol myristate acetate (PMA) or haemin.	Tetradecanoylphorbol Acetate	223-226	protein kinase C alpha	Homo sapiens	0-3
8616013-4	1996	PKC catalytic activity in the nuclei of HEL cells showed a peak after acute (30 min) treatment with PMA, followed by a significant (P &lt; 0.05) decline after prolonged exposure (72 h) to the same agonist, when most HEL cells had acquired a differentiated megakaryocytic phenotype.	Tetradecanoylphorbol Acetate	100-103	protein kinase C alpha	Homo sapiens	0-3
8616013-5	1996	Western blot analysis of nuclear lysates consistently showed a significant increase of PKC-alpha, -beta I, -epsilon, theta and -zeta isoforms after 30 min of PMA treatment, followed by a drastic decline of all but PKC-zeta isoforms.	Tetradecanoylphorbol Acetate	158-161	protein kinase C alpha	Homo sapiens	87-96
8631129-10	1996	TCDD did not increase mRNA of c-fos, c-jun, junB or junD (in contrast to TPA which markedly increased the expression of c-fos and junB), nor did TCDD increase AP-1 activity.	Tetradecanoylphorbol Acetate	73-76	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-134
8778231-4	1996	Adrenocorticotropin (ACTH) treatment increased c-myc mRNA accumulation dose- and time-dependently up to more than 5-fold (on average), with the maximal effect at 2 h. (Bu)2cAMP and 12-O-tetradecanoyl phorbol 13-acetate (TPA) also induced c-myc gene expression.	Tetradecanoylphorbol Acetate	181-218	proopiomelanocortin	Homo sapiens	21-25
8736127-3	1996	We have previously shown that phorbol 12-myristate 13-acetate (PMA), an activator of the calcium- and phospholipid-dependent protein kinase (PKC) is able to mimic all the responses triggered by ACTH in these cells, including steroidogenesis stimulation.	Tetradecanoylphorbol Acetate	30-61	proopiomelanocortin	Homo sapiens	194-198
8736127-3	1996	We have previously shown that phorbol 12-myristate 13-acetate (PMA), an activator of the calcium- and phospholipid-dependent protein kinase (PKC) is able to mimic all the responses triggered by ACTH in these cells, including steroidogenesis stimulation.	Tetradecanoylphorbol Acetate	63-66	proopiomelanocortin	Homo sapiens	194-198
8736127-4	1996	Short (2 h) treatment with PMA leads to only 20-30% of the maximal steroidogenesis stimulation obtained with ACTH.	Tetradecanoylphorbol Acetate	27-30	proopiomelanocortin	Homo sapiens	109-113
8736127-5	1996	However, the steroid secretion in the 2 h that follows the short-term (2 h) PMA treatment reaches the same levels as observed with ACTH, i.e., a 12- to 15-fold increase.	Tetradecanoylphorbol Acetate	76-79	proopiomelanocortin	Homo sapiens	131-135
8608807-1	1996	Tumor necrosis factor (TNF), like granulocyte-macrophage colony-stimul ating factor (GM-CSF), rapidly primed human monocytes for enhanced release of superoxide (O-2) stimulated by receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A), but not by phorbol myristate acetate (PMA), which bypasses the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	294-319	tumor necrosis factor	Homo sapiens	0-21
8608807-1	1996	Tumor necrosis factor (TNF), like granulocyte-macrophage colony-stimul ating factor (GM-CSF), rapidly primed human monocytes for enhanced release of superoxide (O-2) stimulated by receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A), but not by phorbol myristate acetate (PMA), which bypasses the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	294-319	tumor necrosis factor	Homo sapiens	23-26
8608807-1	1996	Tumor necrosis factor (TNF), like granulocyte-macrophage colony-stimul ating factor (GM-CSF), rapidly primed human monocytes for enhanced release of superoxide (O-2) stimulated by receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A), but not by phorbol myristate acetate (PMA), which bypasses the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	321-324	tumor necrosis factor	Homo sapiens	0-21
8608807-1	1996	Tumor necrosis factor (TNF), like granulocyte-macrophage colony-stimul ating factor (GM-CSF), rapidly primed human monocytes for enhanced release of superoxide (O-2) stimulated by receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A), but not by phorbol myristate acetate (PMA), which bypasses the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	321-324	tumor necrosis factor	Homo sapiens	23-26
8778231-4	1996	Adrenocorticotropin (ACTH) treatment increased c-myc mRNA accumulation dose- and time-dependently up to more than 5-fold (on average), with the maximal effect at 2 h. (Bu)2cAMP and 12-O-tetradecanoyl phorbol 13-acetate (TPA) also induced c-myc gene expression.	Tetradecanoylphorbol Acetate	220-223	proopiomelanocortin	Homo sapiens	21-25
8769870-9	1996	The accumulation of total 3H-inositol (poly) phosphates in response to bradykinin or histamine was essentially abolished by prior treatment with 10-min PMA treatment (1 microM).	Tetradecanoylphorbol Acetate	152-155	kininogen 1	Homo sapiens	71-81
8846167-8	1996	Stimulation of monocytes using phorbol myristate acetate resulted in increased binding of monocytes on fibrinogen but not on bovine serum albumin.	Tetradecanoylphorbol Acetate	31-56	fibrinogen beta chain	Homo sapiens	103-113
8769870-10	1996	However, with 12-h exposure to PMA, the bradykinin response was restored to the level seen with no prior PMA exposure.	Tetradecanoylphorbol Acetate	31-34	kininogen 1	Homo sapiens	40-50
8846167-9	1996	When PKC activity was reduced through prolonged incubation with PMA for 16 h, a significant reduction of monocyte adhesion on fibrinogen was observed.	Tetradecanoylphorbol Acetate	64-67	fibrinogen beta chain	Homo sapiens	126-136
8627671-10	1996	Although ConB (25 nM) and BFLA1 (100 nM) blocked phorbol myristate acetate- and Nef-induced CD4 degradation in human monocyte U937 cells, CD4 surface expression was not recovered.	Tetradecanoylphorbol Acetate	49-74	CD4 molecule	Homo sapiens	92-95
8626786-2	1996	In HL60 cells, the membrane-bound phospholipase D (PLD) was stimulated by 4beta-phorbol 12-myristate 13-acetate (PMA) in the presence of the cytosolic fraction from HL60 cells or rat brain.	Tetradecanoylphorbol Acetate	74-111	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	34-49
8643084-3	1996	Both the inhibition of intracellular Ca2+ response by phospholipase C inhibitor U73122 and the down-regulation of protein kinase C (PKC) by pretreatment with phorbol 12-myristate-13-acetate (PMA) partially blocked the ET-1-induced mitogenic responses.	Tetradecanoylphorbol Acetate	158-189	endothelin 1	Homo sapiens	218-222
8643084-4	1996	Wortmannin, a phosphatidylinositol-3-kinase inhibitor, caused dose-dependent inhibition of the ET-1-induced mitogenic responses in both PMA-treated and -untreated cells.	Tetradecanoylphorbol Acetate	136-139	endothelin 1	Homo sapiens	95-99
8599837-6	1996	Under the same conditions, only 0.1 microgram/ml of CsA inhibited by &gt;95% the transactivation of the IL-2 promoter in response to ionomycin and PMA.	Tetradecanoylphorbol Acetate	147-150	interleukin 2	Homo sapiens	104-108
8635491-6	1996	Acute treatment with 10 ng/ml EGF or 20 nM PMA stimulated phospholipid-dependent PKC translocation from the cytosolic to the membrane fraction, and this effect was blocked by prior treatment for 7 days with 20 nM PMA.	Tetradecanoylphorbol Acetate	43-46	protein kinase C, alpha	Mus musculus	81-84
8626786-2	1996	In HL60 cells, the membrane-bound phospholipase D (PLD) was stimulated by 4beta-phorbol 12-myristate 13-acetate (PMA) in the presence of the cytosolic fraction from HL60 cells or rat brain.	Tetradecanoylphorbol Acetate	74-111	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	51-54
8635491-6	1996	Acute treatment with 10 ng/ml EGF or 20 nM PMA stimulated phospholipid-dependent PKC translocation from the cytosolic to the membrane fraction, and this effect was blocked by prior treatment for 7 days with 20 nM PMA.	Tetradecanoylphorbol Acetate	213-216	protein kinase C, alpha	Mus musculus	81-84
8635491-7	1996	Western blot analysis showed that chronic treatment with 1-10 nM PMA for 6 days caused only slight decrease in relative PKC alpha levels in the cytosolic and membrane fractions, while similar treatment with 20-100 nM PMA caused a large down-regulation in total cellular phospholipid-dependent PKC alpha levels.	Tetradecanoylphorbol Acetate	65-68	protein kinase C, alpha	Mus musculus	120-129
8645270-3	1996	However, when the agonist was concanavalin A (ConA) or phorbol 12-myristate 13-acetate (PMA), rac 1 and rac 2, but not the p190 GAP, were translocated.	Tetradecanoylphorbol Acetate	55-86	Rac family small GTPase 2	Homo sapiens	104-109
8635491-7	1996	Western blot analysis showed that chronic treatment with 1-10 nM PMA for 6 days caused only slight decrease in relative PKC alpha levels in the cytosolic and membrane fractions, while similar treatment with 20-100 nM PMA caused a large down-regulation in total cellular phospholipid-dependent PKC alpha levels.	Tetradecanoylphorbol Acetate	65-68	protein kinase C, alpha	Mus musculus	293-302
8626786-2	1996	In HL60 cells, the membrane-bound phospholipase D (PLD) was stimulated by 4beta-phorbol 12-myristate 13-acetate (PMA) in the presence of the cytosolic fraction from HL60 cells or rat brain.	Tetradecanoylphorbol Acetate	113-116	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	34-49
8635491-7	1996	Western blot analysis showed that chronic treatment with 1-10 nM PMA for 6 days caused only slight decrease in relative PKC alpha levels in the cytosolic and membrane fractions, while similar treatment with 20-100 nM PMA caused a large down-regulation in total cellular phospholipid-dependent PKC alpha levels.	Tetradecanoylphorbol Acetate	217-220	protein kinase C, alpha	Mus musculus	120-129
8645270-3	1996	However, when the agonist was concanavalin A (ConA) or phorbol 12-myristate 13-acetate (PMA), rac 1 and rac 2, but not the p190 GAP, were translocated.	Tetradecanoylphorbol Acetate	88-91	Rac family small GTPase 2	Homo sapiens	104-109
8635491-7	1996	Western blot analysis showed that chronic treatment with 1-10 nM PMA for 6 days caused only slight decrease in relative PKC alpha levels in the cytosolic and membrane fractions, while similar treatment with 20-100 nM PMA caused a large down-regulation in total cellular phospholipid-dependent PKC alpha levels.	Tetradecanoylphorbol Acetate	217-220	protein kinase C, alpha	Mus musculus	293-302
8626786-2	1996	In HL60 cells, the membrane-bound phospholipase D (PLD) was stimulated by 4beta-phorbol 12-myristate 13-acetate (PMA) in the presence of the cytosolic fraction from HL60 cells or rat brain.	Tetradecanoylphorbol Acetate	113-116	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	51-54
8632900-3	1996	In this study we have used a previously characterized TPA-responsive element (VLTRE) that binds Rel/NF-kappa B proteins and a Ras-responsive element (B10 RRE) to analyse the signalling pathway in UVB-stimulated gene transcription in cultured keratinocytes.	Tetradecanoylphorbol Acetate	54-57	nuclear factor kappa B subunit 1	Homo sapiens	100-110
8632900-4	1996	We demonstrate that the tumour promoters TPA and UVB use different signalling intermediates to activate different sets of Rel/NF-kappa B proteins.	Tetradecanoylphorbol Acetate	41-44	nuclear factor kappa B subunit 1	Homo sapiens	126-136
8562968-6	1996	Similarly, PMA enhanced HEL cell adhesion to immobilized fibrinogen by 10-fold.	Tetradecanoylphorbol Acetate	11-14	fibrinogen beta chain	Homo sapiens	57-67
8603737-3	1996	We found that phorbol myristate acetate (PMA) activates the src family tyrosine kinases p58c-fgr and p53/56lyn in suspended PMNs.	Tetradecanoylphorbol Acetate	14-39	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	60-63
8603737-3	1996	We found that phorbol myristate acetate (PMA) activates the src family tyrosine kinases p58c-fgr and p53/56lyn in suspended PMNs.	Tetradecanoylphorbol Acetate	14-39	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	88-96
8603737-3	1996	We found that phorbol myristate acetate (PMA) activates the src family tyrosine kinases p58c-fgr and p53/56lyn in suspended PMNs.	Tetradecanoylphorbol Acetate	14-39	tumor protein p53	Homo sapiens	101-104
8603737-3	1996	We found that phorbol myristate acetate (PMA) activates the src family tyrosine kinases p58c-fgr and p53/56lyn in suspended PMNs.	Tetradecanoylphorbol Acetate	41-44	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	60-63
8603737-3	1996	We found that phorbol myristate acetate (PMA) activates the src family tyrosine kinases p58c-fgr and p53/56lyn in suspended PMNs.	Tetradecanoylphorbol Acetate	41-44	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	88-96
8603737-3	1996	We found that phorbol myristate acetate (PMA) activates the src family tyrosine kinases p58c-fgr and p53/56lyn in suspended PMNs.	Tetradecanoylphorbol Acetate	41-44	tumor protein p53	Homo sapiens	101-104
8603737-4	1996	Moreover, we found that up to about 20% of p58c-fgr and p53/56lyn redistribute to a Triton X-100-insoluble fraction after PMA stimulation, and it is this fraction of the two kinases which diplays an increased activity.	Tetradecanoylphorbol Acetate	122-125	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	43-51
8603737-4	1996	Moreover, we found that up to about 20% of p58c-fgr and p53/56lyn redistribute to a Triton X-100-insoluble fraction after PMA stimulation, and it is this fraction of the two kinases which diplays an increased activity.	Tetradecanoylphorbol Acetate	122-125	tumor protein p53	Homo sapiens	56-59
8621697-0	1996	Activation of epidermal growth factor receptor gene transcription by phorbol 12-myristate 13-acetate is mediated by activator protein 2.	Tetradecanoylphorbol Acetate	69-100	epidermal growth factor receptor	Homo sapiens	14-46
8621697-1	1996	The response of the epidermal growth factor (EGF) receptor gene to phorbol 12-myristate 13-acetate (PMA) was analyzed using nuclei and nuclear extracts prepared from PMA-treated KB cells.	Tetradecanoylphorbol Acetate	67-98	epidermal growth factor receptor	Homo sapiens	20-58
8621697-1	1996	The response of the epidermal growth factor (EGF) receptor gene to phorbol 12-myristate 13-acetate (PMA) was analyzed using nuclei and nuclear extracts prepared from PMA-treated KB cells.	Tetradecanoylphorbol Acetate	100-103	epidermal growth factor receptor	Homo sapiens	20-58
8820410-1	1996	The reorientational properties of the fluorescently labelled protein kinase C (PKC) cofactors diacylglycerol (DG) and phorbol ester (PMA) in vesicles and mixed micelles have been investigated using time-resolved polarised fluorescence.	Tetradecanoylphorbol Acetate	133-136	proline rich transmembrane protein 2	Homo sapiens	61-77
8820410-1	1996	The reorientational properties of the fluorescently labelled protein kinase C (PKC) cofactors diacylglycerol (DG) and phorbol ester (PMA) in vesicles and mixed micelles have been investigated using time-resolved polarised fluorescence.	Tetradecanoylphorbol Acetate	133-136	proline rich transmembrane protein 2	Homo sapiens	79-82
8603706-1	1996	12-O-Tetradecanoylphorbol 13-acetate (TPA) elicited a transient increase in the transcription of the inducible nitric oxide synthase (iNOS) gene coupled with a shortening of the half-life of its mRNA in primary neonatal rat hepatocytes.	Tetradecanoylphorbol Acetate	0-36	nitric oxide synthase 2	Rattus norvegicus	101-132
8603706-1	1996	12-O-Tetradecanoylphorbol 13-acetate (TPA) elicited a transient increase in the transcription of the inducible nitric oxide synthase (iNOS) gene coupled with a shortening of the half-life of its mRNA in primary neonatal rat hepatocytes.	Tetradecanoylphorbol Acetate	0-36	nitric oxide synthase 2	Rattus norvegicus	134-138
8603706-1	1996	12-O-Tetradecanoylphorbol 13-acetate (TPA) elicited a transient increase in the transcription of the inducible nitric oxide synthase (iNOS) gene coupled with a shortening of the half-life of its mRNA in primary neonatal rat hepatocytes.	Tetradecanoylphorbol Acetate	38-41	nitric oxide synthase 2	Rattus norvegicus	101-132
8603706-1	1996	12-O-Tetradecanoylphorbol 13-acetate (TPA) elicited a transient increase in the transcription of the inducible nitric oxide synthase (iNOS) gene coupled with a shortening of the half-life of its mRNA in primary neonatal rat hepatocytes.	Tetradecanoylphorbol Acetate	38-41	nitric oxide synthase 2	Rattus norvegicus	134-138
8603706-4	1996	When given together, TPA and CHX exerted additive effects on hepatocellular iNOS mRNA levels.	Tetradecanoylphorbol Acetate	21-24	nitric oxide synthase 2	Rattus norvegicus	76-80
8603706-5	1996	These results suggest the likelihood of an ordered sequence of events by which an activated NF-kappa B mediates the induction of iNOS gene expression in TPA- and/or CHX-treated primary hepatocytes.	Tetradecanoylphorbol Acetate	153-156	nitric oxide synthase 2	Rattus norvegicus	129-133
8779927-6	1996	This effect is not specific to PI3K, since aggregation of phospholipase C-gamma 1 to the activated bFGF receptor is also decreased by PMA treatment.	Tetradecanoylphorbol Acetate	134-137	phospholipase C, gamma 1	Rattus norvegicus	58-81
8850300-2	1996	125I-Labeled LF (125I-LF) bound to THP-1 cells, and the binding increased markedly as the cells matured into macrophages (THP-1 macrophages) by stimulation with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	161-192	GLI family zinc finger 2	Homo sapiens	122-127
8562972-0	1996	TPA-induced arrest of erythroid differentiation is coupled with downregulation of GATA-1 and upregulation of GATA-2 in an erythroid cell line SAM-1.	Tetradecanoylphorbol Acetate	0-3	GATA binding protein 1	Homo sapiens	82-88
8562972-4	1996	In this report, we performed specific and quantitative measurements of GATA-1 and GATA-2 protein in a new erythroid cell line, SAM-1, after treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	155-191	GATA binding protein 1	Homo sapiens	71-77
8562972-4	1996	In this report, we performed specific and quantitative measurements of GATA-1 and GATA-2 protein in a new erythroid cell line, SAM-1, after treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	193-196	GATA binding protein 1	Homo sapiens	71-77
8562972-5	1996	On the basis of these measurements, we show that TPA-induced arrest of erythroid differentiation is coupled with the upregulation of GATA-2 protein, as well as the downregulation of GATA-1 protein.	Tetradecanoylphorbol Acetate	49-52	GATA binding protein 1	Homo sapiens	182-188
8775226-1	1996	Tissue type plasminogen activator (tPA) plays a role in differentiation of neurones and activity-dependent structural changes in neurones.	Tetradecanoylphorbol Acetate	35-38	plasminogen activator, tissue type	Homo sapiens	0-33
8654390-2	1996	The human heme-oxygenase-1 gene is transcriptionally activated through the cis-regulatory element (MTE), GTCATATGAC (positions -156 to -147), during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of myelomonocytic cell lines, such as THP-1, to macrophages.	Tetradecanoylphorbol Acetate	149-185	GLI family zinc finger 2	Homo sapiens	254-259
8654390-2	1996	The human heme-oxygenase-1 gene is transcriptionally activated through the cis-regulatory element (MTE), GTCATATGAC (positions -156 to -147), during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of myelomonocytic cell lines, such as THP-1, to macrophages.	Tetradecanoylphorbol Acetate	187-190	GLI family zinc finger 2	Homo sapiens	254-259
8565310-5	1996	The CD4+ T cell clones from both the salivary gland and autologous peripheral blood were of the Th1 phenotype, in that they produced interferon-gamma (IFN-gamma) and IL-2 but very little IL-4 after 24 h stimulation with phorbol myristate acetate and anti-CD3 antibody.	Tetradecanoylphorbol Acetate	220-245	CD4 molecule	Homo sapiens	4-7
8579606-5	1996	The suppressive effect of CT on hydroperoxide production was reversed by further addition of H7 or by pretreatment with phorbol 12-myristate 13-acetate for 24 h. These results suggest that CT prevents CCl4-induced oxyradical production and cellular damage through activation of protein kinase C in hepatocytes.	Tetradecanoylphorbol Acetate	120-151	C-C motif chemokine ligand 4	Rattus norvegicus	201-205
8567051-6	1996	Acute activation (15 minutes) of PKC by phorbol 12-myristate 13-acetate (PMA) blocked responsiveness to both Ang II and AVP.	Tetradecanoylphorbol Acetate	40-71	angiotensinogen	Rattus norvegicus	109-115
8567051-6	1996	Acute activation (15 minutes) of PKC by phorbol 12-myristate 13-acetate (PMA) blocked responsiveness to both Ang II and AVP.	Tetradecanoylphorbol Acetate	73-76	angiotensinogen	Rattus norvegicus	109-115
8655628-0	1996	Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17 beta-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	48-84	estrogen receptor 1	Homo sapiens	110-127
8655628-3	1996	Comparative studies were conducted with E2 and 12-O-tetradecanoylphorbol-13-acetate (TPA), as both compounds are known to suppress ER expression.	Tetradecanoylphorbol Acetate	47-83	estrogen receptor 1	Homo sapiens	131-133
8655628-3	1996	Comparative studies were conducted with E2 and 12-O-tetradecanoylphorbol-13-acetate (TPA), as both compounds are known to suppress ER expression.	Tetradecanoylphorbol Acetate	85-88	estrogen receptor 1	Homo sapiens	131-133
8655628-4	1996	Our results indicate that 1 nM E2 and 100 nM TPA both suppress ER mRNA levels as early as 4 h after exposure and to 33.6% and 16.5% of control levels, respectively, after 72 h. In contrast, no significant effect on ER mRNA levels was attributed to exposure to 10 nM TCDD.	Tetradecanoylphorbol Acetate	45-48	estrogen receptor 1	Homo sapiens	63-65
8655628-4	1996	Our results indicate that 1 nM E2 and 100 nM TPA both suppress ER mRNA levels as early as 4 h after exposure and to 33.6% and 16.5% of control levels, respectively, after 72 h. In contrast, no significant effect on ER mRNA levels was attributed to exposure to 10 nM TCDD.	Tetradecanoylphorbol Acetate	45-48	estrogen receptor 1	Homo sapiens	215-217
8655628-5	1996	A greater than 50% reduction in positive staining was observed by ER-ICA after 72 h exposure to 1 nM E2 and to 100 nM TPA, while only an 11% reduction in positive staining was observed with 10 nM TCDD.	Tetradecanoylphorbol Acetate	118-121	estrogen receptor 1	Homo sapiens	66-68
8655628-8	1996	In conclusion, while TPA and E2 effectively down-regulate ER expression, TCDD, under antiestrogenic conditions, has little if any effect on total ER levels in MCF-7 cells, and thus ER modulation is probably not necessary for the suppression of estrogenic activity in MCF-7 cells by TCDD.	Tetradecanoylphorbol Acetate	21-24	estrogen receptor 1	Homo sapiens	58-60
8822342-9	1996	Furthermore, pretreatment with the PKC activator phorbol myristate acetate (PMA) (80 nM) markedly increased subsequent NTPPPH induction by both bFGF and cAMP.	Tetradecanoylphorbol Acetate	49-74	fibroblast growth factor 2	Homo sapiens	144-148
8822342-9	1996	Furthermore, pretreatment with the PKC activator phorbol myristate acetate (PMA) (80 nM) markedly increased subsequent NTPPPH induction by both bFGF and cAMP.	Tetradecanoylphorbol Acetate	76-79	fibroblast growth factor 2	Homo sapiens	144-148
8839232-9	1996	A protein kinase C activator, TPA, up-regulated the amount of IA beta mRNA, while a protein kinase C inhibitor, H-7, suppressed the effects of all three cytokines.	Tetradecanoylphorbol Acetate	30-33	histocompatibility 2, class II antigen A, beta 1	Mus musculus	62-69
8604001-5	1996	This phenotype was stable and was specific to LPS since colony-stimulating factor 1 and phorbol myristate acetate had no effect on G418 resistance.	Tetradecanoylphorbol Acetate	88-113	toll-like receptor 4	Mus musculus	46-49
8786383-3	1996	PKC was activated by: (a) exposure of cultures to 10 nM 12-o-tetradecanoyl phorbol 13-acetate (TPA); (b) microinjection of 1 mM dioctanoylglycerol (diC8) directly into perikaryal of motor neurons;(c) addition of 10 microM diC8 to culture medium.	Tetradecanoylphorbol Acetate	56-93	proline rich transmembrane protein 2	Homo sapiens	0-3
8786383-3	1996	PKC was activated by: (a) exposure of cultures to 10 nM 12-o-tetradecanoyl phorbol 13-acetate (TPA); (b) microinjection of 1 mM dioctanoylglycerol (diC8) directly into perikaryal of motor neurons;(c) addition of 10 microM diC8 to culture medium.	Tetradecanoylphorbol Acetate	95-98	proline rich transmembrane protein 2	Homo sapiens	0-3
8739558-2	1996	TPA, known as a protein kinase C (PKC)-activator, supports normal human melanocyte growth and influences on melanocyte dendrite formation.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	16-32
8739558-2	1996	TPA, known as a protein kinase C (PKC)-activator, supports normal human melanocyte growth and influences on melanocyte dendrite formation.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	34-37
8739558-3	1996	We have further confirmed the role of the PKC-mediated pathway in the TPA-dependent melanocyte functions-i.e., proliferation, morphology, and adhesion-using Calphostin C (CPC), a highly specific PKC inhibitor.	Tetradecanoylphorbol Acetate	70-73	proline rich transmembrane protein 2	Homo sapiens	42-45
8739558-3	1996	We have further confirmed the role of the PKC-mediated pathway in the TPA-dependent melanocyte functions-i.e., proliferation, morphology, and adhesion-using Calphostin C (CPC), a highly specific PKC inhibitor.	Tetradecanoylphorbol Acetate	70-73	proline rich transmembrane protein 2	Homo sapiens	195-198
8739558-7	1996	Significant levels of PKC were detected in melanocytes chronically exposed to TPA as determined by Western blotting.	Tetradecanoylphorbol Acetate	78-81	proline rich transmembrane protein 2	Homo sapiens	22-25
8739558-10	1996	These results indicated the critical involvement of PKC activation in the TPA-dependent melanocyte functions.	Tetradecanoylphorbol Acetate	74-77	proline rich transmembrane protein 2	Homo sapiens	52-55
8739558-11	1996	Continuous activation of PKC by TPA is implicated in melanocyte growth stimulation.	Tetradecanoylphorbol Acetate	32-35	proline rich transmembrane protein 2	Homo sapiens	25-28
8635587-1	1996	Our recent studies have shown that intracellular levels of sphingosine, an endogenous PKC inhibitor, increase during apoptosis resulting from phorbol ester (PMA)-induced terminal differentiation of human myeloid leukemic HL-60 cells, and have suggested that sphingosine may function as an endogenous mediator of apoptosis in these cells [Ohta, et al.	Tetradecanoylphorbol Acetate	157-160	proline rich transmembrane protein 2	Homo sapiens	86-89
8635587-4	1996	We report here that apoptosis induced by PMA, sphingosine, and N,N-dimethylsphingosine (DMS) was accompanied by a concomitant decrease of bcl-2 expression in both RNA and protein levels in HL-60 cells, while expression of bcl-XL and bax mRNA did not change, and neither sphingosine nor DMS induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	41-44	BCL2 apoptosis regulator	Homo sapiens	138-143
8635587-4	1996	We report here that apoptosis induced by PMA, sphingosine, and N,N-dimethylsphingosine (DMS) was accompanied by a concomitant decrease of bcl-2 expression in both RNA and protein levels in HL-60 cells, while expression of bcl-XL and bax mRNA did not change, and neither sphingosine nor DMS induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	41-44	BCL2 like 1	Homo sapiens	222-228
8635587-4	1996	We report here that apoptosis induced by PMA, sphingosine, and N,N-dimethylsphingosine (DMS) was accompanied by a concomitant decrease of bcl-2 expression in both RNA and protein levels in HL-60 cells, while expression of bcl-XL and bax mRNA did not change, and neither sphingosine nor DMS induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	41-44	BCL2 associated X, apoptosis regulator	Homo sapiens	233-236
8579603-3	1996	The arsenical compound, phenylarsine oxide (PAO), which reacts with vicinal sulhydryl groups, activated twofold at one minute the PMA stimulated-PLD activity, whereas it inhibited half of the fMLP-activated PLD after a time lag of 30 sec.	Tetradecanoylphorbol Acetate	130-133	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	145-148
8579603-3	1996	The arsenical compound, phenylarsine oxide (PAO), which reacts with vicinal sulhydryl groups, activated twofold at one minute the PMA stimulated-PLD activity, whereas it inhibited half of the fMLP-activated PLD after a time lag of 30 sec.	Tetradecanoylphorbol Acetate	130-133	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	207-210
8555272-13	1996	Furthermore, PMA-stimulated PLD activity was also significantly reduced by a preincubation of PMN with C2-ceramide.	Tetradecanoylphorbol Acetate	13-16	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	28-31
8543831-4	1996	In monocytic Mono Mac6 cells stimulated with the phorbolester tetradecanoyl phorbolacetate (TPA), thioredoxin was found to augment the expression of TNF at the protein and mRNA levels.	Tetradecanoylphorbol Acetate	62-90	tumor necrosis factor	Homo sapiens	149-152
8543831-7	1996	In addition, in TPA-activated Molt-4 T cells, an increased expression of IL-2 and IL-2-specific transcripts was detected.	Tetradecanoylphorbol Acetate	16-19	interleukin 2	Homo sapiens	82-86
8561786-1	1996	Treatments of serum-starved NIH 3T3 fibroblasts with either 100 nM phorbol-12-myristate 13-acetate (PMA) or 1 mM choline phosphate (ChoP) greatly enhanced, in a mutually inhibitory manner, the stimulatory effect of insulin on DNA synthesis.	Tetradecanoylphorbol Acetate	67-98	insulin	Homo sapiens	215-222
8561786-1	1996	Treatments of serum-starved NIH 3T3 fibroblasts with either 100 nM phorbol-12-myristate 13-acetate (PMA) or 1 mM choline phosphate (ChoP) greatly enhanced, in a mutually inhibitory manner, the stimulatory effect of insulin on DNA synthesis.	Tetradecanoylphorbol Acetate	100-103	insulin	Homo sapiens	215-222
8543805-6	1996	In contrast, PMA, which directly activates PKC, induced rapid pim-1 expression.	Tetradecanoylphorbol Acetate	13-16	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	62-67
8543805-7	1996	Further, anti-CD3- or PMA-induced pim-1 expression was markedly reduced by various PKC inhibitors and by deficiency of the PKC epsilon isoform in a mutant T cell line.	Tetradecanoylphorbol Acetate	22-25	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
8543831-4	1996	In monocytic Mono Mac6 cells stimulated with the phorbolester tetradecanoyl phorbolacetate (TPA), thioredoxin was found to augment the expression of TNF at the protein and mRNA levels.	Tetradecanoylphorbol Acetate	92-95	tumor necrosis factor	Homo sapiens	149-152
8543831-6	1996	Treatment of TPA-stimulated Mono Mac6 cells resulted in a strong potentiation of secreted IL-1 bioactivity and expression of IL-1 alpha and IL-8 mRNA.	Tetradecanoylphorbol Acetate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
8543831-7	1996	In addition, in TPA-activated Molt-4 T cells, an increased expression of IL-2 and IL-2-specific transcripts was detected.	Tetradecanoylphorbol Acetate	16-19	interleukin 2	Homo sapiens	73-77
8886182-9	1996	These actions of PTH were mimicked by dibutyryl cyclic AMP and 12-o-tetradecanoylphorbol-13-acetate(TPA) and were abolished by H-89 (an inhibitor of protein kinase A), staurosporine (an inhibitor of protein kinase C), and the calcium channel blockers verapamil or nifedipine.	Tetradecanoylphorbol Acetate	63-99	parathyroid hormone	Homo sapiens	17-20
8549674-0	1996	1,25-dihydroxyvitamin D3 primes acute promyelocytic cells for TPA-induced monocytic differentiation through both PKC and tyrosine phosphorylation cascades.	Tetradecanoylphorbol Acetate	62-65	proline rich transmembrane protein 2	Homo sapiens	113-116
8573121-5	1996	The present study examined the effect of ADT pretreatment on NF-kappa B activation in response to a variety of stimuli such as H2O2, phorbol myristate acetate (PMA) or tumor necrosis factor alpha (TNF alpha).	Tetradecanoylphorbol Acetate	133-158	nuclear factor kappa B subunit 1	Homo sapiens	61-71
8573121-5	1996	The present study examined the effect of ADT pretreatment on NF-kappa B activation in response to a variety of stimuli such as H2O2, phorbol myristate acetate (PMA) or tumor necrosis factor alpha (TNF alpha).	Tetradecanoylphorbol Acetate	160-163	nuclear factor kappa B subunit 1	Homo sapiens	61-71
8555492-9	1996	In contrast to Con A and alpha CD3/alpha CD28 activation, phorbol myristate acetate plus A23187-induced IL-4 mRNA expression was insensitive to the inhibitory effect of db-cAMP and PGE2.	Tetradecanoylphorbol Acetate	58-83	interleukin 4	Homo sapiens	104-108
8822263-10	1996	Preincubation of cells for 60 min with a PKC stimulator, TPA, suppressed FSH-mediated cAMP response in these cells by 40%.	Tetradecanoylphorbol Acetate	57-60	proline rich transmembrane protein 2	Homo sapiens	41-44
8557665-4	1996	We demonstrate that JNK1 was activated by either the T-cell activation signals, anti-CD28 monoclonal antibody plus phorbol 12-myristate 13-acetate (PMA), or the apoptosis-inducing treatment, GR; however, the induction patterns were different.	Tetradecanoylphorbol Acetate	115-146	mitogen-activated protein kinase 8	Homo sapiens	20-24
8557665-4	1996	We demonstrate that JNK1 was activated by either the T-cell activation signals, anti-CD28 monoclonal antibody plus phorbol 12-myristate 13-acetate (PMA), or the apoptosis-inducing treatment, GR; however, the induction patterns were different.	Tetradecanoylphorbol Acetate	148-151	mitogen-activated protein kinase 8	Homo sapiens	20-24
8557667-5	1996	In contrast, selective stimulation of the ERK pathway by 12-O-tetradecanoylphorbol-13-acetate or following expression of constitutively active MEK, the upstream dual specificity kinase of ERK did not induce the transcription of MKP-1.	Tetradecanoylphorbol Acetate	57-93	mitogen-activated protein kinase 1	Homo sapiens	42-45
8825615-5	1996	The virucidal effect of eosinophils, PMA, and bromide under these conditions is inhibited by the peroxidase inhibitor azide and catalase, but not heated catalase or superoxide dismutase, implicating the EPO-H2O2-halide system.	Tetradecanoylphorbol Acetate	37-40	catalase	Homo sapiens	128-136
8886182-9	1996	These actions of PTH were mimicked by dibutyryl cyclic AMP and 12-o-tetradecanoylphorbol-13-acetate(TPA) and were abolished by H-89 (an inhibitor of protein kinase A), staurosporine (an inhibitor of protein kinase C), and the calcium channel blockers verapamil or nifedipine.	Tetradecanoylphorbol Acetate	100-103	parathyroid hormone	Homo sapiens	17-20
8615653-0	1996	Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21).	Tetradecanoylphorbol Acetate	56-59	tumor necrosis factor	Homo sapiens	14-23
8772461-5	1996	TPA treatment induced a decrease in total protein kinase C (PKC)-alpha protein content and a change in subcellular localization from predominantly soluble to predominantly particulate.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Sus scrofa	42-70
8772461-8	1996	PKC-delta was barely detectable in control cells, but content was markedly increased by TPA.	Tetradecanoylphorbol Acetate	88-91	PRKCD	Sus scrofa	0-9
8615653-0	1996	Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21).	Tetradecanoylphorbol Acetate	56-59	interleukin 1 beta	Homo sapiens	28-32
8615653-4	1996	Following TPA stimulation, transcription of TNF-alpha (constitutively present) increased threefold as early as 30 mins and started decreasing by 24h.	Tetradecanoylphorbol Acetate	10-13	tumor necrosis factor	Homo sapiens	44-53
8565269-5	1996	Data showed a significantly higher production of IL-4 (P = 0.05) and IL-10 (P &lt; 0.005) as determined by ELISA in phytohaemagglutinin (PHA)/phorbol myristate acetate (PMA)-stimulated mononuclear cells of atopic donors compared with controls, although spontaneous IL-4 production without stimulation was never detected within either atopic or control groups.	Tetradecanoylphorbol Acetate	142-167	interleukin 4	Homo sapiens	49-53
8547648-12	1996	Treatment of K562 cells with phorbol-12-myristate-13-acetate (PMA) caused a loss of bFGF-binding capacity.	Tetradecanoylphorbol Acetate	29-60	fibroblast growth factor 2	Homo sapiens	84-88
8547648-12	1996	Treatment of K562 cells with phorbol-12-myristate-13-acetate (PMA) caused a loss of bFGF-binding capacity.	Tetradecanoylphorbol Acetate	62-65	fibroblast growth factor 2	Homo sapiens	84-88
8565269-5	1996	Data showed a significantly higher production of IL-4 (P = 0.05) and IL-10 (P &lt; 0.005) as determined by ELISA in phytohaemagglutinin (PHA)/phorbol myristate acetate (PMA)-stimulated mononuclear cells of atopic donors compared with controls, although spontaneous IL-4 production without stimulation was never detected within either atopic or control groups.	Tetradecanoylphorbol Acetate	169-172	interleukin 4	Homo sapiens	49-53
8786004-3	1996	TRH inhibited the contractile response produced by 10(-6) M carbachol in a concentration-dependent manner, with an IC50 value of 4 nM, 2",5"-Dideoxyadenosine and phorbol 12-myristate 13-acetate did not have any significant effect on the TRH-induced relaxation.	Tetradecanoylphorbol Acetate	162-193	thyrotropin releasing hormone	Cavia porcellus	0-3
9084640-8	1996	Further upstream an AP-1 site, overlapped by a steroid hormone response-like sequence, mediates down-regulation of BSP transcription induced by TPA that is abrogated by a complex interaction between Jun and the glucocorticoid receptor protein induced by dexamethasone.	Tetradecanoylphorbol Acetate	144-147	integrin binding sialoprotein	Homo sapiens	115-118
8805224-6	1996	Activation of the serum response element by v-Abl was inhibited by Rac N17 and Ras N17, whereas activation of the TPA response element was inhibited by Rac N17 but not by Ras N17.	Tetradecanoylphorbol Acetate	114-117	AKT serine/threonine kinase 1	Homo sapiens	152-155
8706790-4	1996	In both young and old cells, phorbol myristoyl-13 acetate (PMA) induced the expression of transcripts of collagenase, stromelysin-1, gelatinase-B, TIMP-1, and TIMP-3.	Tetradecanoylphorbol Acetate	59-62	matrix metallopeptidase 3	Homo sapiens	118-131
8536791-5	1996	When REH cells are treated with phorbol myristate acetate (PMA), CD10/NEP transcripts rapidly decrease in a labile protein-dependent manner.	Tetradecanoylphorbol Acetate	32-57	membrane metalloendopeptidase	Homo sapiens	65-69
8536791-5	1996	When REH cells are treated with phorbol myristate acetate (PMA), CD10/NEP transcripts rapidly decrease in a labile protein-dependent manner.	Tetradecanoylphorbol Acetate	32-57	membrane metalloendopeptidase	Homo sapiens	70-73
8536629-6	1996	Treatment with phorbol 12-myristate 13-acetate (TPA) caused 4- to 5-fold induction of MAPK activity in alpha T3-1 cells.	Tetradecanoylphorbol Acetate	15-46	mitogen-activated protein kinase 1	Mus musculus	86-90
8536629-6	1996	Treatment with phorbol 12-myristate 13-acetate (TPA) caused 4- to 5-fold induction of MAPK activity in alpha T3-1 cells.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 1	Mus musculus	86-90
8536629-7	1996	Pretreatment with TPA, however, decreased both GnRH- and TPA-induced MAPK activation, suggesting that PKC is involved in GnRH-mediated activation of MAPK.	Tetradecanoylphorbol Acetate	18-21	mitogen-activated protein kinase 1	Mus musculus	69-73
8536629-7	1996	Pretreatment with TPA, however, decreased both GnRH- and TPA-induced MAPK activation, suggesting that PKC is involved in GnRH-mediated activation of MAPK.	Tetradecanoylphorbol Acetate	18-21	mitogen-activated protein kinase 1	Mus musculus	149-153
8536629-7	1996	Pretreatment with TPA, however, decreased both GnRH- and TPA-induced MAPK activation, suggesting that PKC is involved in GnRH-mediated activation of MAPK.	Tetradecanoylphorbol Acetate	57-60	mitogen-activated protein kinase 1	Mus musculus	69-73
8536629-7	1996	Pretreatment with TPA, however, decreased both GnRH- and TPA-induced MAPK activation, suggesting that PKC is involved in GnRH-mediated activation of MAPK.	Tetradecanoylphorbol Acetate	57-60	mitogen-activated protein kinase 1	Mus musculus	149-153
8536791-5	1996	When REH cells are treated with phorbol myristate acetate (PMA), CD10/NEP transcripts rapidly decrease in a labile protein-dependent manner.	Tetradecanoylphorbol Acetate	59-62	membrane metalloendopeptidase	Homo sapiens	65-69
8536791-5	1996	When REH cells are treated with phorbol myristate acetate (PMA), CD10/NEP transcripts rapidly decrease in a labile protein-dependent manner.	Tetradecanoylphorbol Acetate	59-62	membrane metalloendopeptidase	Homo sapiens	70-73
8706790-4	1996	In both young and old cells, phorbol myristoyl-13 acetate (PMA) induced the expression of transcripts of collagenase, stromelysin-1, gelatinase-B, TIMP-1, and TIMP-3.	Tetradecanoylphorbol Acetate	59-62	TIMP metallopeptidase inhibitor 1	Homo sapiens	147-153
8796372-1	1996	Transcription factor NF kappa B (nuclear factor kappa B) is induced in T lymphocytes from young individuals following activation with a variety of stimuli including anti-CD3, phorbol myristate acetate (PMA), and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	175-200	nuclear factor kappa B subunit 1	Homo sapiens	21-31
8855453-4	1996	Phorbol myristate acetate (PMA) and ADP, which stimulate the respiratory burst, caused NF Kappa B activation in both cells.	Tetradecanoylphorbol Acetate	0-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-97
8855453-4	1996	Phorbol myristate acetate (PMA) and ADP, which stimulate the respiratory burst, caused NF Kappa B activation in both cells.	Tetradecanoylphorbol Acetate	27-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-97
8550736-16	1996	Predictably, the addition of D-phenyl-alanyl-propyl-arginine-chloromethyl ketone, blocked the effects of thrombin on PAI-1, tPA, and uPA protein and mRNA expression and PA activity.	Tetradecanoylphorbol Acetate	124-127	coagulation factor II, thrombin	Homo sapiens	105-113
8550736-3	1996	Therefore, we evaluated whether thrombin affected the expression of endometrial stromal cell urokinase-type (uPA) and tissue-type (tPA) plasminogen activators and their primary inhibitor, type 1 plasminogen activator inhibitor (PAI-1), and whether ovarian steroids modulated putative thrombin effects.	Tetradecanoylphorbol Acetate	131-134	coagulation factor II, thrombin	Homo sapiens	32-40
8557777-10	1996	In Ca(2+)- or PMA-stimulated cells, FITC-dextran was delivered to endosomes that had been labeled with TRITC-transferrin.	Tetradecanoylphorbol Acetate	14-17	transferrin	Homo sapiens	109-120
8550736-8	1996	Thrombin added in the absence of exogenous steroids elevated concentrations of ir tPA, uPA, and PAI-1 compared with control cultures.	Tetradecanoylphorbol Acetate	82-85	coagulation factor II, thrombin	Homo sapiens	0-8
8550736-10	1996	Interestingly, thrombin counteracted this progestin inhibition of tPA and uPA expression and augmented the progestin-enhanced expression of PAI-1.	Tetradecanoylphorbol Acetate	66-69	coagulation factor II, thrombin	Homo sapiens	15-23
8550736-11	1996	Northern analysis revealed that steady state levels of tPA and uPA mRNA were also enhanced by thrombin in both control and steroid-containing cultures.	Tetradecanoylphorbol Acetate	55-58	coagulation factor II, thrombin	Homo sapiens	94-102
8550736-14	1996	However, thrombin elicited significant increases in tPA and uPA activity in control and E2-treated cultures.	Tetradecanoylphorbol Acetate	52-55	coagulation factor II, thrombin	Homo sapiens	9-17
8926285-7	1996	Phorbol myristate acetate (PMA) and ionophore stimulated TNF-alpha and IFN-gamma secretion in both the binder and the killer subsets, though IFN-gamma secretion was more pronounced in the binder subset.	Tetradecanoylphorbol Acetate	0-25	tumor necrosis factor	Homo sapiens	57-66
8825422-9	1996	Both oleic acid and PMA potentiated glucose-induced insulin release but oleic acid, in contrast to PMA, was unable to initiate insulin release in the presence of substimulatory concentrations of glucose.	Tetradecanoylphorbol Acetate	20-23	insulin	Homo sapiens	52-59
8926285-7	1996	Phorbol myristate acetate (PMA) and ionophore stimulated TNF-alpha and IFN-gamma secretion in both the binder and the killer subsets, though IFN-gamma secretion was more pronounced in the binder subset.	Tetradecanoylphorbol Acetate	0-25	interferon gamma	Homo sapiens	71-80
8926285-7	1996	Phorbol myristate acetate (PMA) and ionophore stimulated TNF-alpha and IFN-gamma secretion in both the binder and the killer subsets, though IFN-gamma secretion was more pronounced in the binder subset.	Tetradecanoylphorbol Acetate	0-25	interferon gamma	Homo sapiens	141-150
8926285-7	1996	Phorbol myristate acetate (PMA) and ionophore stimulated TNF-alpha and IFN-gamma secretion in both the binder and the killer subsets, though IFN-gamma secretion was more pronounced in the binder subset.	Tetradecanoylphorbol Acetate	27-30	tumor necrosis factor	Homo sapiens	57-66
8926285-7	1996	Phorbol myristate acetate (PMA) and ionophore stimulated TNF-alpha and IFN-gamma secretion in both the binder and the killer subsets, though IFN-gamma secretion was more pronounced in the binder subset.	Tetradecanoylphorbol Acetate	27-30	interferon gamma	Homo sapiens	71-80
8558060-10	1996	Anti-TNF-alpha antibodies inhibited PMA-induced NF-kappa B activation.	Tetradecanoylphorbol Acetate	36-39	tumor necrosis factor	Homo sapiens	5-14
8568475-5	1996	Treatment of TFCs with phorbol 12-myristate 13-acetate (8 nmol/l) to activate protein kinase C (PKC) led to an enhanced incorporation of [methyl-3H]thymidine which was increased further after neutralisation of endogenous TGF-beta 1.	Tetradecanoylphorbol Acetate	23-54	transforming growth factor beta 1	Homo sapiens	221-231
8558060-3	1996	Transcription of the TNF-alpha gene was observed after 0.5 h of phorbol myristate acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	64-89	tumor necrosis factor	Homo sapiens	21-30
8558060-10	1996	Anti-TNF-alpha antibodies inhibited PMA-induced NF-kappa B activation.	Tetradecanoylphorbol Acetate	36-39	nuclear factor kappa B subunit 1	Homo sapiens	48-58
8558060-3	1996	Transcription of the TNF-alpha gene was observed after 0.5 h of phorbol myristate acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	91-94	tumor necrosis factor	Homo sapiens	21-30
8745210-12	1996	In addition, the protein kinase C activator, phorbol 12-myristate 13-acetate, stimulated exchanger activity by 32%, raising the possibility that all three Gq agonists mediate their actions in part through the promotion of phospholipase C activity and the subsequent activation of protein kinase C. The contribution of Na+/Ca2+ exchange to the actions of phenylephrine, angiotensin II, and endothelin 1 is discussed.	Tetradecanoylphorbol Acetate	45-76	angiotensinogen	Homo sapiens	369-383
8558060-7	1996	Protein kinase C (PKC) and protein tyrosine kinase (PTK) inhibition essentially abolished both PMA-induced TNF-alpha protein secretion and collagenase mRNA expression.	Tetradecanoylphorbol Acetate	95-98	tumor necrosis factor	Homo sapiens	107-116
8598451-5	1996	In contrast, PMA and ionomycin induced only minimal CD40L expression by neonatal T cells, whereas adult memory T cells expressed CD40L comparably after stimulation with PMA and ionomycin or anti-CD3.	Tetradecanoylphorbol Acetate	13-16	CD40 ligand	Homo sapiens	52-57
8598451-5	1996	In contrast, PMA and ionomycin induced only minimal CD40L expression by neonatal T cells, whereas adult memory T cells expressed CD40L comparably after stimulation with PMA and ionomycin or anti-CD3.	Tetradecanoylphorbol Acetate	169-172	CD40 ligand	Homo sapiens	129-134
8592085-3	1996	Transcription of IL-6 mRNA was first detectable 2 h after stimulation with the ester phorbol myristate acetate (PMA) and the calcium ionophore A23187 in both cell lines, as evidenced by semiquantitative reverse transcriptase polymerase chain reaction analysis.	Tetradecanoylphorbol Acetate	85-110	interleukin 6	Homo sapiens	17-21
8592085-3	1996	Transcription of IL-6 mRNA was first detectable 2 h after stimulation with the ester phorbol myristate acetate (PMA) and the calcium ionophore A23187 in both cell lines, as evidenced by semiquantitative reverse transcriptase polymerase chain reaction analysis.	Tetradecanoylphorbol Acetate	112-115	interleukin 6	Homo sapiens	17-21
8745210-12	1996	In addition, the protein kinase C activator, phorbol 12-myristate 13-acetate, stimulated exchanger activity by 32%, raising the possibility that all three Gq agonists mediate their actions in part through the promotion of phospholipase C activity and the subsequent activation of protein kinase C. The contribution of Na+/Ca2+ exchange to the actions of phenylephrine, angiotensin II, and endothelin 1 is discussed.	Tetradecanoylphorbol Acetate	45-76	endothelin 1	Homo sapiens	389-401
8786703-4	1996	Phorbol 12-myristate 13-acetate (PMA) arrests the constitutive cycling of THP-1 and induces a phenotype that approaches normalcy.	Tetradecanoylphorbol Acetate	0-31	GLI family zinc finger 2	Homo sapiens	74-79
8699936-3	1996	We report herein that neutrophils from poorly controlled diabetics have impaired ability to generate superoxide in response to N-formyl-Met-Leu-Phe (FMLP) but not to 4 beta-phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	206-209	formyl peptide receptor 1	Homo sapiens	149-153
8632715-8	1996	Overnight pretreatment of the cardiac myocytes with 100 ng/ml pertussis toxin inhibited the ET-1 stimulated increase in MAPK activity by 50 - 70%, but did not alter stimulation by 100 nM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	220-223	endothelin 1	Homo sapiens	92-96
8786703-4	1996	Phorbol 12-myristate 13-acetate (PMA) arrests the constitutive cycling of THP-1 and induces a phenotype that approaches normalcy.	Tetradecanoylphorbol Acetate	33-36	GLI family zinc finger 2	Homo sapiens	74-79
8908614-0	1996	Augmentation of interferon production after cell-differentiation of U937 cells by TPA.	Tetradecanoylphorbol Acetate	82-85	interferon alpha 1	Homo sapiens	16-26
8890934-5	1996	Activation of PKC with TPA diminished the number of BK receptors by 33% and proportionally decreased BK-mediated Ins(1,4,5)P3 formation by 28%.	Tetradecanoylphorbol Acetate	23-26	kininogen 1	Homo sapiens	52-54
8890934-5	1996	Activation of PKC with TPA diminished the number of BK receptors by 33% and proportionally decreased BK-mediated Ins(1,4,5)P3 formation by 28%.	Tetradecanoylphorbol Acetate	23-26	kininogen 1	Homo sapiens	101-103
8908614-4	1996	Induction of cell differentiation and augmentation of IFN production by TPA were demonstrated in U937 cells persistently infected with mumps virus (U937-MP).	Tetradecanoylphorbol Acetate	72-75	interferon alpha 1	Homo sapiens	54-57
8838148-10	1996	In the resultant 301 cells, TSH beta LUC activity was increased 2- to 3-fold by TRH or PMA; nimodipine, Bay K8644, and removal of extracellular Ca2+ had no effect.	Tetradecanoylphorbol Acetate	87-90	thyroid stimulating hormone subunit beta	Rattus norvegicus	28-36
8838148-8	1996	The protein kinase C activator, PMA (100 nM) also stimulated TSH beta LUC transcription, but its effect was not inhibited by nimodipine.	Tetradecanoylphorbol Acetate	32-35	thyroid stimulating hormone subunit beta	Rattus norvegicus	61-69
21594347-2	1996	TPA treated U937 monoblastoid cells expressed Cip1, hypophosphorylated retinoblastoma protein (Rb), arrested in G(1) and differentiated.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	46-50
8895200-2	1996	The PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced daunomycin accumulation in both drug-sensitive KB-3-1 and MDR KB-C1 cells in a time-dependent manner.	Tetradecanoylphorbol Acetate	18-54	proline rich transmembrane protein 2	Homo sapiens	4-7
8895200-2	1996	The PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced daunomycin accumulation in both drug-sensitive KB-3-1 and MDR KB-C1 cells in a time-dependent manner.	Tetradecanoylphorbol Acetate	56-59	proline rich transmembrane protein 2	Homo sapiens	4-7
8895200-7	1996	TPA initially induced translocation of PKCs alpha and delta, and to a lesser extent, PKC epsilon to the membrane fraction; 8 h after TPA treatment, differential effects on downregulation of PKCs alpha and delta were observed between cell lines, although PKC epsilon was not reduced in either cell line.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	39-59
8895200-7	1996	TPA initially induced translocation of PKCs alpha and delta, and to a lesser extent, PKC epsilon to the membrane fraction; 8 h after TPA treatment, differential effects on downregulation of PKCs alpha and delta were observed between cell lines, although PKC epsilon was not reduced in either cell line.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	190-210
8895200-8	1996	We therefore propose that the TPA-induced reduction in daunomycin accumulation in KB cells is due to a PKC-mediated process, which is maintained after depletion of certain PKC subspecies or is due to activation of downregulation insensitive PKC subspecies.	Tetradecanoylphorbol Acetate	30-33	proline rich transmembrane protein 2	Homo sapiens	103-106
8895200-8	1996	We therefore propose that the TPA-induced reduction in daunomycin accumulation in KB cells is due to a PKC-mediated process, which is maintained after depletion of certain PKC subspecies or is due to activation of downregulation insensitive PKC subspecies.	Tetradecanoylphorbol Acetate	30-33	proline rich transmembrane protein 2	Homo sapiens	172-175
8895200-8	1996	We therefore propose that the TPA-induced reduction in daunomycin accumulation in KB cells is due to a PKC-mediated process, which is maintained after depletion of certain PKC subspecies or is due to activation of downregulation insensitive PKC subspecies.	Tetradecanoylphorbol Acetate	30-33	proline rich transmembrane protein 2	Homo sapiens	172-175
21594347-5	1996	TPA treated PKC-zeta cells express Cip1 and display substantial hypophosphorylation of Rb but fail to arrest in G(1).	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	35-39
8825394-7	1996	PMA-stimulated production of O2- increased when cells were preincubated with several doses of ET-1 (5 x 10(-13) to 2 x 10(-12) M), whereas ET-3 was without effect.	Tetradecanoylphorbol Acetate	0-3	endothelin 1	Homo sapiens	94-98
8788440-5	1995	Down-regulation of protein kinase C (by treatment with phorbol 12-myristate 13-acetate for 20 h) shifted the concentration-response curves for these agonists to the right before and after desensitization of the endothelin ETB receptor 3.7- to 59-fold.	Tetradecanoylphorbol Acetate	55-86	endothelin receptor type B	Oryctolagus cuniculus	211-234
8807709-8	1996	Finally, we demonstrated that the functional thrombin receptor is internalized after addition of thrombin and thrombin receptor-activating peptide (homologous internalization) and also after phorbol myristate acetate addition (heterologous internalization).	Tetradecanoylphorbol Acetate	191-216	coagulation factor II, thrombin	Homo sapiens	45-53
8713799-6	1996	Activation of protein kinase C with 12-O-tetradecanoyl phorbol-13-acetate resulted in simultaneous loss of both stress fibers and fibrinogen binding.	Tetradecanoylphorbol Acetate	36-73	fibrinogen beta chain	Homo sapiens	130-140
8537383-6	1995	Phorbol-12-myristate 13-acetate (10(-7) M) treatment, however, induced VEGF mRNA expression in both HUVECs and HMECs, peaking at 3 and 6 h, respectively, and returning to undetectable levels by 12 h. In vitro exposure of HUVECs to a hypoxic environment (pO2 = 35 mm of mercury) for 12, 24, and 48 h and exposure of HMECs for 6, 12, 24, and 48 h induced VEGF mRNA in a time-dependent fashion.	Tetradecanoylphorbol Acetate	0-31	vascular endothelial growth factor A	Homo sapiens	71-75
8537383-6	1995	Phorbol-12-myristate 13-acetate (10(-7) M) treatment, however, induced VEGF mRNA expression in both HUVECs and HMECs, peaking at 3 and 6 h, respectively, and returning to undetectable levels by 12 h. In vitro exposure of HUVECs to a hypoxic environment (pO2 = 35 mm of mercury) for 12, 24, and 48 h and exposure of HMECs for 6, 12, 24, and 48 h induced VEGF mRNA in a time-dependent fashion.	Tetradecanoylphorbol Acetate	0-31	vascular endothelial growth factor A	Homo sapiens	353-357
8537390-6	1995	Differently, phorbol 12-myristate 13-acetate induced a significant proteolysis of both I kappa B alpha and p105 in the cytoplasm, while it did not affect the protein level of p105 in the nucleus.	Tetradecanoylphorbol Acetate	13-44	NFKB inhibitor alpha	Homo sapiens	87-102
8537390-6	1995	Differently, phorbol 12-myristate 13-acetate induced a significant proteolysis of both I kappa B alpha and p105 in the cytoplasm, while it did not affect the protein level of p105 in the nucleus.	Tetradecanoylphorbol Acetate	13-44	nuclear factor kappa B subunit 1	Homo sapiens	107-111
7503727-1	1995	Acute TPA treatment (1h, 100nM) of a human pancreatic carcinoid cell line (BON) depletes cell contents of chromogranin A (CGA) and pancreastatin (PST), a peptide derived posttranslationally from CGA.	Tetradecanoylphorbol Acetate	6-9	chromogranin A	Homo sapiens	106-120
8530360-6	1995	Phorbol 12-myristate 13-acetate did not activate the JNKs although it activated ERK1 and ERK2, which phosphorylated the c-Jun transactivation domain in vitro.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 3	Homo sapiens	80-84
8530360-6	1995	Phorbol 12-myristate 13-acetate did not activate the JNKs although it activated ERK1 and ERK2, which phosphorylated the c-Jun transactivation domain in vitro.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 1	Homo sapiens	89-93
7499867-8	1995	Thus, we examined the effects of Ab-opsonized glass bead ingestion, okadaic acid-mediated inhibition of phosphatases, and PMA treatment on the activity of pPL and on its distribution between the cytosolic and membrane-associated compartments.	Tetradecanoylphorbol Acetate	122-125	periplakin	Homo sapiens	155-158
7499867-10	1995	PMA treatment caused a 1.8-fold increase in membrane-associated pPL activity.	Tetradecanoylphorbol Acetate	0-3	periplakin	Homo sapiens	64-67
7503727-1	1995	Acute TPA treatment (1h, 100nM) of a human pancreatic carcinoid cell line (BON) depletes cell contents of chromogranin A (CGA) and pancreastatin (PST), a peptide derived posttranslationally from CGA.	Tetradecanoylphorbol Acetate	6-9	chromogranin A	Homo sapiens	122-125
7503727-1	1995	Acute TPA treatment (1h, 100nM) of a human pancreatic carcinoid cell line (BON) depletes cell contents of chromogranin A (CGA) and pancreastatin (PST), a peptide derived posttranslationally from CGA.	Tetradecanoylphorbol Acetate	6-9	chromogranin A	Homo sapiens	195-198
7503727-4	1995	Together, these findings indicate that the TPA-induced switch from a regulated to unregulated pattern of CGA secretion is accompanied by a decrease in the processing of CGA to PST and a decrease in the active form of a processing enzyme potentially involved in processing CGA to a smaller peptide, PST.	Tetradecanoylphorbol Acetate	43-46	chromogranin A	Homo sapiens	105-108
7503727-4	1995	Together, these findings indicate that the TPA-induced switch from a regulated to unregulated pattern of CGA secretion is accompanied by a decrease in the processing of CGA to PST and a decrease in the active form of a processing enzyme potentially involved in processing CGA to a smaller peptide, PST.	Tetradecanoylphorbol Acetate	43-46	chromogranin A	Homo sapiens	169-172
7503727-4	1995	Together, these findings indicate that the TPA-induced switch from a regulated to unregulated pattern of CGA secretion is accompanied by a decrease in the processing of CGA to PST and a decrease in the active form of a processing enzyme potentially involved in processing CGA to a smaller peptide, PST.	Tetradecanoylphorbol Acetate	43-46	chromogranin A	Homo sapiens	169-172
7498555-3	1995	Basal and phorbol ester (PMA)-stimulated ET-1 secretion were unaffected by ODQ, but stimulated secretion was increased by L-NNA.	Tetradecanoylphorbol Acetate	25-28	endothelin 1	Homo sapiens	41-45
8547036-5	1995	In response to stimulation with phorbol-12-myristate-13 acetate (PMA), the 16T(-) cells produced more IL-4 and IFN-gamma, whereas the 35T(-) and MH-1 cells exhibited increased secretion of IFN-gamma, but still no IL-4 or IL-4 mRNA production.	Tetradecanoylphorbol Acetate	32-63	interferon gamma	Mus musculus	111-120
8747536-3	1995	The results show that upon treatment of HeLa S3 cells with tumor necrosis factor-alpha or phorbol 12-myristate 13-acetate, or with ionizing radiation, there is a profound induction of NF-kappa B binding activity.	Tetradecanoylphorbol Acetate	90-121	tumor necrosis factor	Homo sapiens	59-86
8747536-3	1995	The results show that upon treatment of HeLa S3 cells with tumor necrosis factor-alpha or phorbol 12-myristate 13-acetate, or with ionizing radiation, there is a profound induction of NF-kappa B binding activity.	Tetradecanoylphorbol Acetate	90-121	nuclear factor kappa B subunit 1	Homo sapiens	184-194
8572233-4	1995	Phorbol 12-myristate 13-acetate, lipopolysaccharide (LPS), and interferon-gamma treatment of rat marrow-derived macrophages increased SP-A binding by 163, 296, and 337%, respectively, over untreated controls.	Tetradecanoylphorbol Acetate	0-31	surfactant protein A1	Rattus norvegicus	134-138
8526850-2	1995	Cox-2 is regulated and expressed in large quantities upon activation of the cells by inducers such as phorbol myristate acetate (PMA), an activator of protein kinase C (PKC), or interleukin-1 alpha.	Tetradecanoylphorbol Acetate	102-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
8526850-2	1995	Cox-2 is regulated and expressed in large quantities upon activation of the cells by inducers such as phorbol myristate acetate (PMA), an activator of protein kinase C (PKC), or interleukin-1 alpha.	Tetradecanoylphorbol Acetate	129-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
8547036-5	1995	In response to stimulation with phorbol-12-myristate-13 acetate (PMA), the 16T(-) cells produced more IL-4 and IFN-gamma, whereas the 35T(-) and MH-1 cells exhibited increased secretion of IFN-gamma, but still no IL-4 or IL-4 mRNA production.	Tetradecanoylphorbol Acetate	32-63	interferon gamma	Mus musculus	189-198
8547036-5	1995	In response to stimulation with phorbol-12-myristate-13 acetate (PMA), the 16T(-) cells produced more IL-4 and IFN-gamma, whereas the 35T(-) and MH-1 cells exhibited increased secretion of IFN-gamma, but still no IL-4 or IL-4 mRNA production.	Tetradecanoylphorbol Acetate	65-68	interferon gamma	Mus musculus	111-120
8547036-5	1995	In response to stimulation with phorbol-12-myristate-13 acetate (PMA), the 16T(-) cells produced more IL-4 and IFN-gamma, whereas the 35T(-) and MH-1 cells exhibited increased secretion of IFN-gamma, but still no IL-4 or IL-4 mRNA production.	Tetradecanoylphorbol Acetate	65-68	interferon gamma	Mus musculus	189-198
8746951-9	1995	The effects of PKC activation on the Ca2+i decline were eliminated by PKC inhibitors, PKC down regulation (24 h PMA pretreatment), ATP-depletion and conditions that inhibited the Ca2+ pump.	Tetradecanoylphorbol Acetate	112-115	proline rich transmembrane protein 2	Homo sapiens	15-18
9815959-7	1995	12-O-tetradecanoylphorbol-13-acetate caused translocation of PKC-alpha from the cytosol to the cell membrane after a 10-min treatment and its down-regulation after 24 h of treatment.	Tetradecanoylphorbol Acetate	0-36	protein kinase C alpha	Homo sapiens	61-70
9019167-10	1995	PKC alpha and delta were activated to a lesser extent by CS than by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	68-104	protein kinase C, alpha	Mus musculus	0-9
7489990-7	1995	After treatment of cells with 12-O-tetradecanoylphorbol-13-acetate and epidermal growth factor (EGF), the decrease in concentrations of endogenous AFP messenger RNA (mRNA) and nls-LacZ mRNA transcribed from the transferred AFP regulatory sequence were similar.	Tetradecanoylphorbol Acetate	30-66	alpha fetoprotein	Homo sapiens	147-150
7588297-8	1995	Phorbol 12-myristate 13-acetate (PMA) induced IL-6 transcripts, and the effect of PDGF BB was inhibited in the presence of the protein kinase C (PKC) inhibitor, sangivamycin, or after down-regulation of PKC by PMA preincubation.	Tetradecanoylphorbol Acetate	0-31	interleukin 6	Rattus norvegicus	46-50
7588297-8	1995	Phorbol 12-myristate 13-acetate (PMA) induced IL-6 transcripts, and the effect of PDGF BB was inhibited in the presence of the protein kinase C (PKC) inhibitor, sangivamycin, or after down-regulation of PKC by PMA preincubation.	Tetradecanoylphorbol Acetate	33-36	interleukin 6	Rattus norvegicus	46-50
9072353-6	1995	The protein kinase C (PKC)-activating phorbol ester, phorbol myristate acetate, stimulated ET-1 production in cells of both rat strains, but this stimulation was significantly greater in cells of SHR than in cells of WKY rats.	Tetradecanoylphorbol Acetate	53-78	endothelin 1	Rattus norvegicus	91-95
8748153-1	1995	When 7721 human hepatocarcinoma cells were treated with 100 nM phorbol-12-myristate-13-acetate (PMA), the activity of N-acetylglucosaminyltransferase V(GnT-V) in the cells varied in accordance with the activity of membranous protein kinase C (PKC), but not with that of cytosolic PKC.	Tetradecanoylphorbol Acetate	63-94	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	118-151
8748153-1	1995	When 7721 human hepatocarcinoma cells were treated with 100 nM phorbol-12-myristate-13-acetate (PMA), the activity of N-acetylglucosaminyltransferase V(GnT-V) in the cells varied in accordance with the activity of membranous protein kinase C (PKC), but not with that of cytosolic PKC.	Tetradecanoylphorbol Acetate	63-94	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	152-157
8748153-1	1995	When 7721 human hepatocarcinoma cells were treated with 100 nM phorbol-12-myristate-13-acetate (PMA), the activity of N-acetylglucosaminyltransferase V(GnT-V) in the cells varied in accordance with the activity of membranous protein kinase C (PKC), but not with that of cytosolic PKC.	Tetradecanoylphorbol Acetate	96-99	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	118-151
8748153-1	1995	When 7721 human hepatocarcinoma cells were treated with 100 nM phorbol-12-myristate-13-acetate (PMA), the activity of N-acetylglucosaminyltransferase V(GnT-V) in the cells varied in accordance with the activity of membranous protein kinase C (PKC), but not with that of cytosolic PKC.	Tetradecanoylphorbol Acetate	96-99	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	152-157
8748153-2	1995	Quercetin, a non-specific inhibitor of Ser/Thr protein kinase, and D-sphingosine and staurosporine, two specific inhibitors of PKC, blocked the activation of membranous PKC and GnT-V by PMA.	Tetradecanoylphorbol Acetate	186-189	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	177-182
7489990-7	1995	After treatment of cells with 12-O-tetradecanoylphorbol-13-acetate and epidermal growth factor (EGF), the decrease in concentrations of endogenous AFP messenger RNA (mRNA) and nls-LacZ mRNA transcribed from the transferred AFP regulatory sequence were similar.	Tetradecanoylphorbol Acetate	30-66	alpha fetoprotein	Homo sapiens	223-226
7490476-5	1995	The IFN-gamma- and anti-Fas antibody-dependent apoptotis was observed by 3 h, and the maximal response was observed by 12 h. The induction of apoptosis was significantly augmented by treatment with 10 ng/ml 12-o-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	207-244	interferon gamma	Homo sapiens	4-13
8543752-4	1995	The release of IL-4 and IFN-gamma from peripheral blood mononuclear cells stimulated by polyclonal agents (calcium ionophore A23187 and phorbol myristate acetate) was measured by ELISA.	Tetradecanoylphorbol Acetate	136-161	interleukin 4	Homo sapiens	15-19
7499370-2	1995	The tyrosine kinase inhibitor herbimycin A was found to block NF-kappa B stimulation in response to interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat T lymphoma cells.	Tetradecanoylphorbol Acetate	118-149	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	62-72
7593234-0	1995	Effect of 1,25-dihydroxyvitamin D3 on induction of scavenger receptor and differentiation of 12-O-tetradecanoylphorbol-13-acetate-treated THP-1 human monocyte like cells.	Tetradecanoylphorbol Acetate	93-129	GLI family zinc finger 2	Homo sapiens	138-143
7593234-7	1995	The mRNA of type I scavenger receptor was first detected in THP-1 cells 4 days after the treatment with TPA, the mRNA level increased up to 6 days, and then decreased.	Tetradecanoylphorbol Acetate	104-107	GLI family zinc finger 2	Homo sapiens	60-65
7593234-10	1995	These findings suggest that 1,25(OH)2D3 exclusively decreases the expression of scavenger receptors in TPA-induced THP-1 macrophages without affecting the basic cellular functions as macrophages.	Tetradecanoylphorbol Acetate	103-106	GLI family zinc finger 2	Homo sapiens	115-120
8647994-4	1995	NHKs secreted detectable levels of IL-8, but not of IL-6, and IL-8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	129-160	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
8647994-4	1995	NHKs secreted detectable levels of IL-8, but not of IL-6, and IL-8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	129-160	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
8647994-4	1995	NHKs secreted detectable levels of IL-8, but not of IL-6, and IL-8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
8647994-4	1995	NHKs secreted detectable levels of IL-8, but not of IL-6, and IL-8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	62-66
7490476-5	1995	The IFN-gamma- and anti-Fas antibody-dependent apoptotis was observed by 3 h, and the maximal response was observed by 12 h. The induction of apoptosis was significantly augmented by treatment with 10 ng/ml 12-o-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	246-249	interferon gamma	Homo sapiens	4-13
7594530-8	1995	To determine whether TAPI would prevent shedding under more physiologic conditions, we demonstrated that TAPI was able to prevent unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes.	Tetradecanoylphorbol Acetate	147-150	tumor necrosis factor	Homo sapiens	191-200
7494315-10	1995	Differentiation of the monocytes to macrophages by 12-O-tetradecanoylphorbol-13-acetate treatment resulted in increased expression of PGHS-1 and increased formation of prostaglandins compared with that for the monocytes.	Tetradecanoylphorbol Acetate	51-87	prostaglandin-endoperoxide synthase 1	Homo sapiens	134-140
7594530-8	1995	To determine whether TAPI would prevent shedding under more physiologic conditions, we demonstrated that TAPI was able to prevent unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes.	Tetradecanoylphorbol Acetate	147-150	interleukin 6 receptor	Homo sapiens	216-221
7594530-4	1995	As expected, TAPI blocked the spontaneous and PMA-induced release of TNF-alpha from transfected cells.	Tetradecanoylphorbol Acetate	46-49	tumor necrosis factor	Homo sapiens	69-78
7595543-6	1995	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate induced interleukin-6 production, and treatment with a combination of this phorbol ester and interleukin-1 produced synergistic stimulation.	Tetradecanoylphorbol Acetate	18-54	interleukin 6	Homo sapiens	63-76
8750912-6	1995	The effect of thrombin seemed to be unrelated to intracellular Ca2+ release but could be partially mimicked by phorbol ester (PMA)-induced stimulation of protein kinase C (PKC) and was inhibited by staurosporin or by inactivation of PKC after long-term incubation with PMA.	Tetradecanoylphorbol Acetate	126-129	coagulation factor II, thrombin	Homo sapiens	14-22
8632663-3	1995	TPA treatment also enhanced the expression of GPIIb mRNA, and induced the expression of interleukin-6 (IL-6) and its receptor mRNAs, while it did not induce transcripts of the genes IL-11 and mpl ligand, and further decreased the transcript of the mpl gene.	Tetradecanoylphorbol Acetate	0-3	interleukin 6	Homo sapiens	88-101
8632663-3	1995	TPA treatment also enhanced the expression of GPIIb mRNA, and induced the expression of interleukin-6 (IL-6) and its receptor mRNAs, while it did not induce transcripts of the genes IL-11 and mpl ligand, and further decreased the transcript of the mpl gene.	Tetradecanoylphorbol Acetate	0-3	interleukin 6	Homo sapiens	103-107
8632663-3	1995	TPA treatment also enhanced the expression of GPIIb mRNA, and induced the expression of interleukin-6 (IL-6) and its receptor mRNAs, while it did not induce transcripts of the genes IL-11 and mpl ligand, and further decreased the transcript of the mpl gene.	Tetradecanoylphorbol Acetate	0-3	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	248-251
8632663-4	1995	Consistent with these findings, MC3 cells treated with TPA showed an increased expression of GATA-1, but not GATA-3 transcripts, whereas those without TPA treatment expressed only the GATA-2 transcript.	Tetradecanoylphorbol Acetate	55-58	GATA binding protein 1	Homo sapiens	93-99
7491516-10	1995	In both FTC-133 and FTC-238, TPA incubations of 0.1 to 100 ng/ml caused a dose-dependent increase in uPA and a 94 kd type IV collagenase.	Tetradecanoylphorbol Acetate	29-32	plasminogen activator, urokinase	Homo sapiens	101-104
8848016-2	1995	In C6 glioma cells, short term (10 min) treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) results in a dose-dependent translocation of PKC alpha, PKC delta and PKC theta.	Tetradecanoylphorbol Acetate	55-92	protein kinase C alpha	Homo sapiens	144-153
8848016-2	1995	In C6 glioma cells, short term (10 min) treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) results in a dose-dependent translocation of PKC alpha, PKC delta and PKC theta.	Tetradecanoylphorbol Acetate	94-97	protein kinase C alpha	Homo sapiens	144-153
8848016-3	1995	Long term (24 hr) treatment with appropriate doses of TPA results in the complete down-regulation of PKC delta but not of PKC alpha PKC theta.	Tetradecanoylphorbol Acetate	54-57	protein kinase C alpha	Homo sapiens	122-131
8848016-8	1995	We have shown that the Na(+)-H+ exchanger in C6 glioma cells can be stimulated by TPA-induced PKC activation and, for the first time, that PKC delta is involved in the activation of this antiporter.	Tetradecanoylphorbol Acetate	82-85	protein kinase C alpha	Homo sapiens	94-97
8521977-1	1995	The regulation of apolipoprotein A-I (apo A-I) gene expression by 12-O-tetradecanoylphorbol 13-acetate (TPA) was investigated in the human hepatoma cell line Hep G2.	Tetradecanoylphorbol Acetate	66-102	apolipoprotein A1	Homo sapiens	18-36
8521977-1	1995	The regulation of apolipoprotein A-I (apo A-I) gene expression by 12-O-tetradecanoylphorbol 13-acetate (TPA) was investigated in the human hepatoma cell line Hep G2.	Tetradecanoylphorbol Acetate	66-102	apolipoprotein A1	Homo sapiens	38-45
8521977-1	1995	The regulation of apolipoprotein A-I (apo A-I) gene expression by 12-O-tetradecanoylphorbol 13-acetate (TPA) was investigated in the human hepatoma cell line Hep G2.	Tetradecanoylphorbol Acetate	104-107	apolipoprotein A1	Homo sapiens	18-36
8521977-1	1995	The regulation of apolipoprotein A-I (apo A-I) gene expression by 12-O-tetradecanoylphorbol 13-acetate (TPA) was investigated in the human hepatoma cell line Hep G2.	Tetradecanoylphorbol Acetate	104-107	apolipoprotein A1	Homo sapiens	38-45
8521977-2	1995	TPA treatment decreased apo A-I mRNA levels in a time-dependent manner, by up to 50% versus control cells within 24 h. Nuclear run-on transcription assays demonstrated a transcriptional effect of TPA.	Tetradecanoylphorbol Acetate	0-3	apolipoprotein A1	Homo sapiens	24-31
8521977-2	1995	TPA treatment decreased apo A-I mRNA levels in a time-dependent manner, by up to 50% versus control cells within 24 h. Nuclear run-on transcription assays demonstrated a transcriptional effect of TPA.	Tetradecanoylphorbol Acetate	196-199	apolipoprotein A1	Homo sapiens	24-31
8521977-3	1995	Using transfection analysis with a plasmid construct containing the -1378/+11 apo A-I promoter fused to the secreted placental alkaline phosphatase (SPAP) reporter gene, we showed that the SPAP activity was decreased to 50% when Hep G2 cells were incubated in the presence of TPA.	Tetradecanoylphorbol Acetate	276-279	apolipoprotein A1	Homo sapiens	78-85
8521977-4	1995	The inhibitory effect of TPA was still maintained when fragment -253 to -4 of apo A-I promoter was linked to the CAT reporter gene.	Tetradecanoylphorbol Acetate	25-28	apolipoprotein A1	Homo sapiens	78-85
7585603-5	1995	The target element of the suppression was a 12-O-tetradecanoylphorbol-13-acetate-responsive element located 61 nucleotides upstream from the cap site, which is also internal to a Maf consensus binding sequence.	Tetradecanoylphorbol Acetate	44-80	MAF bZIP transcription factor	Rattus norvegicus	179-182
7492337-2	1995	This sensitivity involves the gene tpa-1, which encodes two protein kinase C isoforms, TPA-1A and TPA-1B.	Tetradecanoylphorbol Acetate	87-90	Protein kinase C-like 1	Caenorhabditis elegans	35-40
7492337-2	1995	This sensitivity involves the gene tpa-1, which encodes two protein kinase C isoforms, TPA-1A and TPA-1B.	Tetradecanoylphorbol Acetate	98-101	Protein kinase C-like 1	Caenorhabditis elegans	35-40
7594491-10	1995	Moreover, NIF prevented PMA-induced neutrophil adhesion to fibrinogen, a CD11b/CD18-dependent event, but produced a smaller decrease in adherence to endothelial cells, which also involves CD11a/CD18 integrins.	Tetradecanoylphorbol Acetate	24-27	integrin subunit beta 2	Homo sapiens	79-83
7594459-3	1995	These activated T cells produced IL-2, IL-4, IL-5, and IFN-gamma upon stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	87-90	interleukin 4	Homo sapiens	39-43
7594459-3	1995	These activated T cells produced IL-2, IL-4, IL-5, and IFN-gamma upon stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	87-90	interferon gamma	Homo sapiens	55-64
7594468-7	1995	Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus.	Tetradecanoylphorbol Acetate	78-81	NFKB inhibitor alpha	Homo sapiens	90-99
7594468-7	1995	Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus.	Tetradecanoylphorbol Acetate	78-81	NFKB inhibitor alpha	Homo sapiens	232-241
7594450-1	1995	An intact cAMP response element (CRE) in the upstream regulatory sequence of IL-1 beta (-2755/-2762) has been shown to be essential for maintaining full IL-1 beta inducibility following treatment with LPS, PMA, or TNF-alpha.	Tetradecanoylphorbol Acetate	206-209	interleukin 1 beta	Homo sapiens	77-86
7594450-1	1995	An intact cAMP response element (CRE) in the upstream regulatory sequence of IL-1 beta (-2755/-2762) has been shown to be essential for maintaining full IL-1 beta inducibility following treatment with LPS, PMA, or TNF-alpha.	Tetradecanoylphorbol Acetate	206-209	interleukin 1 beta	Homo sapiens	153-162
7594459-3	1995	These activated T cells produced IL-2, IL-4, IL-5, and IFN-gamma upon stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	87-90	interleukin 2	Homo sapiens	33-37
7488130-3	1995	Further studies showed that 12-O-tetradecanoyl phorbol 13-acetate (TPA) enhanced the accumulation of WAF1; cells refractory to TPA still increased their levels of WAF1 mRNA when exposed to IL-1.	Tetradecanoylphorbol Acetate	28-65	cyclin dependent kinase inhibitor 1A	Homo sapiens	101-105
7594468-7	1995	Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA-induced IkB alpha phosphorylation/degradation irrespective of activation of Ca(2+)-dependent pathways, but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha, a PKC-independent stimulus.	Tetradecanoylphorbol Acetate	78-81	tumor necrosis factor	Homo sapiens	253-262
7488149-3	1995	Cu2+ was found to inhibit the activation of NF kappa B induced by TNF-alpha, TPA, or H2O2.	Tetradecanoylphorbol Acetate	77-80	nuclear factor kappa B subunit 1	Homo sapiens	44-54
7488130-3	1995	Further studies showed that 12-O-tetradecanoyl phorbol 13-acetate (TPA) enhanced the accumulation of WAF1; cells refractory to TPA still increased their levels of WAF1 mRNA when exposed to IL-1.	Tetradecanoylphorbol Acetate	67-70	cyclin dependent kinase inhibitor 1A	Homo sapiens	101-105
8555017-1	1995	In this study we have used a human hair follicle whole-organ culture system to examine the effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a potent activator of protein kinase C (PKC), on hair follicle growth and hair fibre production.	Tetradecanoylphorbol Acetate	102-139	proline rich transmembrane protein 2	Homo sapiens	169-185
7498491-0	1995	The recombinant GABA transporter GAT1 is downregulated upon activation of protein kinase C. Treatment of human embryonic kidney 293 cells expressing the rat gamma-aminobutyric acid (GABA) transporter 1 (GAT1) with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) was found to decrease the velocity of specific [3H]GABA uptake.	Tetradecanoylphorbol Acetate	284-287	solute carrier family 6 member 1	Homo sapiens	33-37
7576691-6	1995	Furthermore, treatment of REC monolayers with TNF-alpha or IL-1 beta significantly increased adhesion of PMA-stimulated eosinophils (P &lt; 0.01).	Tetradecanoylphorbol Acetate	105-108	tumor necrosis factor	Homo sapiens	46-55
7576691-6	1995	Furthermore, treatment of REC monolayers with TNF-alpha or IL-1 beta significantly increased adhesion of PMA-stimulated eosinophils (P &lt; 0.01).	Tetradecanoylphorbol Acetate	105-108	interleukin 1 beta	Homo sapiens	59-68
7498491-0	1995	The recombinant GABA transporter GAT1 is downregulated upon activation of protein kinase C. Treatment of human embryonic kidney 293 cells expressing the rat gamma-aminobutyric acid (GABA) transporter 1 (GAT1) with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) was found to decrease the velocity of specific [3H]GABA uptake.	Tetradecanoylphorbol Acetate	251-282	solute carrier family 6 member 1	Homo sapiens	33-37
7589583-0	1995	The protein kinase C activator TPA modulates cellular levels and distribution of E-cadherin in HT-29 human intestinal epithelial cells.	Tetradecanoylphorbol Acetate	31-34	cadherin 1	Homo sapiens	81-91
7589583-3	1995	The phorbol ester TPA differently affected E-cadherin levels in HT-29 M6 cells; at day 2-3, when most E-cadherin was found not-associated to the cytoskeleton, very important decreases (90%) in the total levels of this protein were detected as soon as 6 h after the addition of this compound.	Tetradecanoylphorbol Acetate	18-21	cadherin 1	Homo sapiens	43-53
7589583-3	1995	The phorbol ester TPA differently affected E-cadherin levels in HT-29 M6 cells; at day 2-3, when most E-cadherin was found not-associated to the cytoskeleton, very important decreases (90%) in the total levels of this protein were detected as soon as 6 h after the addition of this compound.	Tetradecanoylphorbol Acetate	18-21	cadherin 1	Homo sapiens	102-112
8555017-1	1995	In this study we have used a human hair follicle whole-organ culture system to examine the effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a potent activator of protein kinase C (PKC), on hair follicle growth and hair fibre production.	Tetradecanoylphorbol Acetate	102-139	proline rich transmembrane protein 2	Homo sapiens	187-190
8555017-1	1995	In this study we have used a human hair follicle whole-organ culture system to examine the effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a potent activator of protein kinase C (PKC), on hair follicle growth and hair fibre production.	Tetradecanoylphorbol Acetate	141-144	proline rich transmembrane protein 2	Homo sapiens	169-185
8588923-2	1995	This method, for use with the particulate neutrophil activator, is a modification of the cytochrome c reduction system that measures O2- release from adherent neutrophils stimulated with soluble mediators such as phorbol-myristate-acetate (PMA).	Tetradecanoylphorbol Acetate	213-238	LOC101107954	Ovis aries	89-101
8555017-1	1995	In this study we have used a human hair follicle whole-organ culture system to examine the effects of 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a potent activator of protein kinase C (PKC), on hair follicle growth and hair fibre production.	Tetradecanoylphorbol Acetate	141-144	proline rich transmembrane protein 2	Homo sapiens	187-190
8555017-8	1995	The inhibitory effect of TPA on follicle growth was partially prevented by preincubation with the selective PKC inhibitor H-7, and almost completely prevented by preincubation with the more potent PKC inhibitor Ro 31-7549.	Tetradecanoylphorbol Acetate	25-28	proline rich transmembrane protein 2	Homo sapiens	108-111
7585974-8	1995	Although the CD3-/Thy-1+ cells can be activated in vitro by IL-2, TPA, and ionomycin, they cannot be propagated in vitro.	Tetradecanoylphorbol Acetate	66-69	CD247 antigen	Mus musculus	13-16
7585518-4	1995	In the 293.27.2 human kidney cell line, as in hematopoietic cells of all lineages, NF-kappa B is stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 alpha (IL-1 alpha).	Tetradecanoylphorbol Acetate	111-147	nuclear factor kappa B subunit 1	Homo sapiens	83-93
7585518-4	1995	In the 293.27.2 human kidney cell line, as in hematopoietic cells of all lineages, NF-kappa B is stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 alpha (IL-1 alpha).	Tetradecanoylphorbol Acetate	149-152	nuclear factor kappa B subunit 1	Homo sapiens	83-93
7585518-4	1995	In the 293.27.2 human kidney cell line, as in hematopoietic cells of all lineages, NF-kappa B is stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 alpha (IL-1 alpha).	Tetradecanoylphorbol Acetate	149-152	tumor necrosis factor	Homo sapiens	155-182
7585518-4	1995	In the 293.27.2 human kidney cell line, as in hematopoietic cells of all lineages, NF-kappa B is stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 alpha (IL-1 alpha).	Tetradecanoylphorbol Acetate	149-152	tumor necrosis factor	Homo sapiens	184-193
7585518-5	1995	The response to either TNF-alpha or IL-1 alpha is synergistically enhanced by TPA.	Tetradecanoylphorbol Acetate	78-81	tumor necrosis factor	Homo sapiens	23-32
7585518-16	1995	Both ET-18-OCH3 and auranofin inhibited cellular induction of the active NF-kappa B complex in response to TPA but not in response to TNF-alpha.	Tetradecanoylphorbol Acetate	107-110	nuclear factor kappa B subunit 1	Homo sapiens	73-83
7585980-1	1995	Several studies have demonstrated that addition of soluble anti-CD6 mAbs to 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated naive T cells can induce cell proliferation.	Tetradecanoylphorbol Acetate	76-112	CD6 molecule	Homo sapiens	64-67
7585980-1	1995	Several studies have demonstrated that addition of soluble anti-CD6 mAbs to 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated naive T cells can induce cell proliferation.	Tetradecanoylphorbol Acetate	114-117	CD6 molecule	Homo sapiens	64-67
8595373-14	1995	In addition the effect of CD28 co-stimulation on IL-2 mRNA stabilisation was demonstrated by the maintenance of a high frequency of IL-2 expressing CD4 T cells and an elevated level of mRNA per cell for prolonged period after PMA+Io stimulation.	Tetradecanoylphorbol Acetate	226-229	interleukin 2	Homo sapiens	49-53
7585980-2	1995	We showed in the present study that cell proliferation in TPA-treated T cell cultures can be enhanced several fold when the anti-CD6 mAbs are either immobilized or crosslinked with rabbit anti-mouse immunoglobulins (RAM Ig).	Tetradecanoylphorbol Acetate	58-61	CD6 molecule	Homo sapiens	129-132
7585980-3	1995	Using a src family protein tyrosine kinase (PTK) inhibitor, herbimycin A, the cell proliferation induced by the anti-CD6 mAb, IOR-T1, in TPA-treated T cells were effectively abolished.	Tetradecanoylphorbol Acetate	137-140	EPH receptor A8	Homo sapiens	19-42
7585980-3	1995	Using a src family protein tyrosine kinase (PTK) inhibitor, herbimycin A, the cell proliferation induced by the anti-CD6 mAb, IOR-T1, in TPA-treated T cells were effectively abolished.	Tetradecanoylphorbol Acetate	137-140	EPH receptor A8	Homo sapiens	44-47
7585980-3	1995	Using a src family protein tyrosine kinase (PTK) inhibitor, herbimycin A, the cell proliferation induced by the anti-CD6 mAb, IOR-T1, in TPA-treated T cells were effectively abolished.	Tetradecanoylphorbol Acetate	137-140	CD6 molecule	Homo sapiens	117-120
7585980-4	1995	Analysis of the cellular proteins in these cells after crosslinking the CD6 receptor with IOR-T1 (followed by RAM Ig) in the presence of TPA resulted in an increased level of tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	137-140	CD6 molecule	Homo sapiens	72-75
7585980-6	1995	Similar concentrations of herbimycin A also inhibited the increase in IL-2 mRNA expression and cell proliferation in T cell cultures after IOR-T1/RAM Ig and TPA treatment.	Tetradecanoylphorbol Acetate	157-160	interleukin 2	Homo sapiens	70-74
7585518-8	1995	ET-18-OCH3 markedly inhibits TPA-induced NF-kappa B activation, as measured by HIV long terminal repeat-directed expression of beta-galactosidase.	Tetradecanoylphorbol Acetate	29-32	nuclear factor kappa B subunit 1	Homo sapiens	41-51
7585518-10	1995	Inhibition of TPA-induced NF-kappa B activation was dependent upon preincubation with ET-18-OCH3, and the drug was active at approximately 2 mol% of total cellular phospholipid.	Tetradecanoylphorbol Acetate	14-17	nuclear factor kappa B subunit 1	Homo sapiens	26-36
7585518-13	1995	Like ET-18-OCH3, auranofin blocked NF-kappa B activation by TPA but not by TNF-alpha or IL-1 alpha.	Tetradecanoylphorbol Acetate	60-63	nuclear factor kappa B subunit 1	Homo sapiens	35-45
7589260-8	1995	Treatment with TPA during G1 caused a three to four fold increase in cyclin D1 mRNA expression, but blocked the increase in the expression of cyclin A and cyclin B mRNAs later in the cell cycle.	Tetradecanoylphorbol Acetate	15-18	cyclin A2	Homo sapiens	142-150
7586672-3	1995	The percentage of CD40L+ PBMC after activation in vitro with phorbol myristate acetate (PMA) plus ionomycin was lower in HIV-infected children than in controls (P &lt; 0.004).	Tetradecanoylphorbol Acetate	61-86	CD40 ligand	Homo sapiens	18-23
7586672-3	1995	The percentage of CD40L+ PBMC after activation in vitro with phorbol myristate acetate (PMA) plus ionomycin was lower in HIV-infected children than in controls (P &lt; 0.004).	Tetradecanoylphorbol Acetate	88-91	CD40 ligand	Homo sapiens	18-23
7588214-4	1995	We found that PMA-stimulated DNA synthesis was associated with increments in tyrosine phosphorylation of p44mapk (ERK1) and p42mapk (ERK2) and activation of Raf-1, MKK, and MAPK in these cells.	Tetradecanoylphorbol Acetate	14-17	mitogen-activated protein kinase 3	Homo sapiens	105-112
7588214-4	1995	We found that PMA-stimulated DNA synthesis was associated with increments in tyrosine phosphorylation of p44mapk (ERK1) and p42mapk (ERK2) and activation of Raf-1, MKK, and MAPK in these cells.	Tetradecanoylphorbol Acetate	14-17	mitogen-activated protein kinase 3	Homo sapiens	114-118
7588214-4	1995	We found that PMA-stimulated DNA synthesis was associated with increments in tyrosine phosphorylation of p44mapk (ERK1) and p42mapk (ERK2) and activation of Raf-1, MKK, and MAPK in these cells.	Tetradecanoylphorbol Acetate	14-17	mitogen-activated protein kinase 1	Homo sapiens	124-131
7588214-4	1995	We found that PMA-stimulated DNA synthesis was associated with increments in tyrosine phosphorylation of p44mapk (ERK1) and p42mapk (ERK2) and activation of Raf-1, MKK, and MAPK in these cells.	Tetradecanoylphorbol Acetate	14-17	mitogen-activated protein kinase 1	Homo sapiens	133-137
7586373-10	1995	Phorbol 12-myristate 13-acetate (PMA) also augmented NO synthesis in IL-1 beta-stimulated but not in unstimulated cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-31	interleukin 1 beta	Rattus norvegicus	69-78
7586373-10	1995	Phorbol 12-myristate 13-acetate (PMA) also augmented NO synthesis in IL-1 beta-stimulated but not in unstimulated cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	33-36	interleukin 1 beta	Rattus norvegicus	69-78
7589260-10	1995	Addition of TPA in G1 prevented an increase in cyclin A levels, suggesting cyclin A might play an important role in mediating the growth inhibition.	Tetradecanoylphorbol Acetate	12-15	cyclin A2	Homo sapiens	47-55
7589260-10	1995	Addition of TPA in G1 prevented an increase in cyclin A levels, suggesting cyclin A might play an important role in mediating the growth inhibition.	Tetradecanoylphorbol Acetate	12-15	cyclin A2	Homo sapiens	75-83
7591091-3	1995	To investigate the mechanisms accounting for the impaired responses to gamma interferon, a model system for examining overall changes in protein tyrosine phosphorylation, activation of Jak1 and Jak2 and phosphorylation of Stat1 was developed in phorbol 12-myristate 13-acetate-differentiated U-937 cells.	Tetradecanoylphorbol Acetate	245-276	Janus kinase 1	Homo sapiens	185-189
8550072-5	1995	With adult purified T cells, high levels of IL-10 and IL-4 were measured following CD3 plus CD28 stimulation, and the amounts of both T-helper type-2 (Th2) cytokines decreased following the addition of phorbol myristate acetate (PMA), whereas the synthesis of the Th1 cytokines IL-2 and IFN-gamma was enhanced.	Tetradecanoylphorbol Acetate	202-227	interleukin 4	Homo sapiens	54-58
8550072-5	1995	With adult purified T cells, high levels of IL-10 and IL-4 were measured following CD3 plus CD28 stimulation, and the amounts of both T-helper type-2 (Th2) cytokines decreased following the addition of phorbol myristate acetate (PMA), whereas the synthesis of the Th1 cytokines IL-2 and IFN-gamma was enhanced.	Tetradecanoylphorbol Acetate	202-227	interleukin 2	Homo sapiens	278-282
8550072-5	1995	With adult purified T cells, high levels of IL-10 and IL-4 were measured following CD3 plus CD28 stimulation, and the amounts of both T-helper type-2 (Th2) cytokines decreased following the addition of phorbol myristate acetate (PMA), whereas the synthesis of the Th1 cytokines IL-2 and IFN-gamma was enhanced.	Tetradecanoylphorbol Acetate	202-227	interferon gamma	Homo sapiens	287-296
8586671-3	1995	Anisomycin and okadaic acid activate JNK/SAPKs but not ERKs, and conversely, TPA activates ERKs but not JNK/SAPKs.	Tetradecanoylphorbol Acetate	77-80	mitogen-activated protein kinase 1	Mus musculus	91-95
7593220-7	1995	Chronic exposure of cultures to phorbol 12-myristate 13-acetate to down-regulate PKC resulted in an attenuation of thrombin-induced p42 Tyr phosphorylation, although H-7, a known PKC inhibitor, failed to block thrombin effect.	Tetradecanoylphorbol Acetate	32-63	coagulation factor II	Rattus norvegicus	115-123
7499501-3	1995	Moreover, incubation with increasing PMA concentrations showed a progressive enhancement of chemotaxis of lymphocytes, which was partially prevented by VIP, and both PACAPs.	Tetradecanoylphorbol Acetate	37-40	vasoactive intestinal polypeptide	Mus musculus	152-155
7594647-6	1995	pim-1 mRNA was stimulated by hydrocortisone and suppressed by the tumor promoter tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	81-110	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-5
8596194-8	1995	The activity of protein kinase C in membranes prepared from intact myocytes pre-treated for 10 min with the phorbol ester, phorbol 12-myristate 13-acetate (PMA) (100 nM), employed as a positive control, and CGRP (10 pM) was significantly greater than in membranes prepared from cardiomyocytes not subjected to agonist stimulation.	Tetradecanoylphorbol Acetate	123-154	proline rich transmembrane protein 2	Homo sapiens	16-32
8590308-8	1995	The results indicated that the inhibition of IFN-gamma was caused by a reduction in the ability of the cells to produce O2- in response to stimulation by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	154-190	interferon gamma	Homo sapiens	45-54
8596194-8	1995	The activity of protein kinase C in membranes prepared from intact myocytes pre-treated for 10 min with the phorbol ester, phorbol 12-myristate 13-acetate (PMA) (100 nM), employed as a positive control, and CGRP (10 pM) was significantly greater than in membranes prepared from cardiomyocytes not subjected to agonist stimulation.	Tetradecanoylphorbol Acetate	156-159	proline rich transmembrane protein 2	Homo sapiens	16-32
8590308-8	1995	The results indicated that the inhibition of IFN-gamma was caused by a reduction in the ability of the cells to produce O2- in response to stimulation by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	192-195	interferon gamma	Homo sapiens	45-54
8656080-8	1995	Treatment of transfected HepG2 cells with phorbol 12-myristate 13-acetate (PMA), a known activator of protein kinase C (PKC), resulted in a time-dependent inhibition of the CYP7 promoter activity.	Tetradecanoylphorbol Acetate	42-73	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	173-177
8656080-8	1995	Treatment of transfected HepG2 cells with phorbol 12-myristate 13-acetate (PMA), a known activator of protein kinase C (PKC), resulted in a time-dependent inhibition of the CYP7 promoter activity.	Tetradecanoylphorbol Acetate	75-78	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	173-177
8575515-6	1995	IS2 and IS3 showed topical anti-inflammatory activity against the TPA-induced ear inflammation in mice, with similar effects on oedema and a higher inhibition of IS3 on leukocyte migration, estimated as myeloperoxidase activity in supernatants of ear homogenates.	Tetradecanoylphorbol Acetate	66-69	IS2	Homo sapiens	0-3
7565762-0	1995	12-O-tetradecanoylphorbol-13-acetate activation of the MDR1 promoter is mediated by EGR1.	Tetradecanoylphorbol Acetate	0-36	ATP binding cassette subfamily B member 1	Homo sapiens	55-59
7565762-3	1995	To identify cellular factors that regulate the expression of MDR1 in hematopoietic cells, we characterized the cis- and trans-acting factors mediating 12-O-tetradecanoylphorbol-13-acetate (TPA) activation of the MDR1 promoter in K562 cells.	Tetradecanoylphorbol Acetate	151-187	ATP binding cassette subfamily B member 1	Homo sapiens	212-216
7565762-3	1995	To identify cellular factors that regulate the expression of MDR1 in hematopoietic cells, we characterized the cis- and trans-acting factors mediating 12-O-tetradecanoylphorbol-13-acetate (TPA) activation of the MDR1 promoter in K562 cells.	Tetradecanoylphorbol Acetate	189-192	ATP binding cassette subfamily B member 1	Homo sapiens	61-65
7565762-3	1995	To identify cellular factors that regulate the expression of MDR1 in hematopoietic cells, we characterized the cis- and trans-acting factors mediating 12-O-tetradecanoylphorbol-13-acetate (TPA) activation of the MDR1 promoter in K562 cells.	Tetradecanoylphorbol Acetate	189-192	ATP binding cassette subfamily B member 1	Homo sapiens	212-216
7565762-4	1995	Transient-transfection assays demonstrated that an MDR1 promoter construct containing nucleotides -69 to +20 conferred a TPA response equal to that of a construct containing nucleotides -434 to +105.	Tetradecanoylphorbol Acetate	121-124	ATP binding cassette subfamily B member 1	Homo sapiens	51-55
7565762-5	1995	TPA induced EGR1 binding to the -69/+20 promoter sequences over a time course which correlated with increased MDR1 promoter activity and increased steady-state MDR1 RNA levels.	Tetradecanoylphorbol Acetate	0-3	ATP binding cassette subfamily B member 1	Homo sapiens	110-114
7565762-5	1995	TPA induced EGR1 binding to the -69/+20 promoter sequences over a time course which correlated with increased MDR1 promoter activity and increased steady-state MDR1 RNA levels.	Tetradecanoylphorbol Acetate	0-3	ATP binding cassette subfamily B member 1	Homo sapiens	160-164
7565762-8	1995	A mutation in this site that inhibited EGR protein binding blocked the -69/+20 MDR1 promoter response to TPA.	Tetradecanoylphorbol Acetate	105-108	ATP binding cassette subfamily B member 1	Homo sapiens	79-83
7488028-1	1995	We identified arginine vasopressin (AVP) as a potent activator of TPA-response element (TRE)-dependent gene expression in rat 3Y1 fibroblasts.	Tetradecanoylphorbol Acetate	66-69	arginine vasopressin	Rattus norvegicus	23-34
7488237-2	1995	The increases in activities of both protein tyrosine phosphatase (PTP) and protein tyrosine kinase (PTK) have been reported to be associated with the TPA-induced differentiation of HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	150-153	EPH receptor A8	Homo sapiens	75-98
7578267-2	1995	Differentiation with the combination of either RA (1 microM) or 1,25-D3 (10 nM) with IFN-gamma (100 IU/ml) induced NADPH oxidase activity as demonstrated by increased superoxide anion (O2-) generation in response to stimulation with phorbol myristate acetate (PMA, 100 nM).	Tetradecanoylphorbol Acetate	233-258	interferon gamma	Homo sapiens	85-94
7578267-2	1995	Differentiation with the combination of either RA (1 microM) or 1,25-D3 (10 nM) with IFN-gamma (100 IU/ml) induced NADPH oxidase activity as demonstrated by increased superoxide anion (O2-) generation in response to stimulation with phorbol myristate acetate (PMA, 100 nM).	Tetradecanoylphorbol Acetate	260-263	interferon gamma	Homo sapiens	85-94
8584237-3	1995	Pretreatment with 100 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances the AII-evoked release of [3H]NA approximately two-fold.	Tetradecanoylphorbol Acetate	25-61	angiotensinogen	Homo sapiens	81-84
8584237-3	1995	Pretreatment with 100 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances the AII-evoked release of [3H]NA approximately two-fold.	Tetradecanoylphorbol Acetate	63-66	angiotensinogen	Homo sapiens	81-84
8584237-4	1995	Removal of extracellular Ca2+ ([Ca2+]o) decreases 100 nM AII-evoked release of [3H]NA by over 50% both in the presence and absence of TPA.	Tetradecanoylphorbol Acetate	134-137	angiotensinogen	Homo sapiens	57-60
8584237-5	1995	AII increases intracellular Ca2+ ([Ca2+]i) in this cell line which is consistent with the AT1A receptor being coupled to phospholipase C. Pretreatment with 100 nM TPA for 8 min attenuated the effect of AII on [Ca2+]i.	Tetradecanoylphorbol Acetate	163-166	angiotensinogen	Homo sapiens	0-3
8584237-5	1995	AII increases intracellular Ca2+ ([Ca2+]i) in this cell line which is consistent with the AT1A receptor being coupled to phospholipase C. Pretreatment with 100 nM TPA for 8 min attenuated the effect of AII on [Ca2+]i.	Tetradecanoylphorbol Acetate	163-166	angiotensinogen	Homo sapiens	202-205
7559663-0	1995	Effects of 12-O-tetradecanoylphorbol-13-acetate on estrogen receptor activity in MCF-7 cells.	Tetradecanoylphorbol Acetate	11-47	estrogen receptor 1	Homo sapiens	51-68
7559663-1	1995	The effects of long term treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) on estrogen receptor (ER) expression in the human breast cancer cell line, MCF-7, were studied.	Tetradecanoylphorbol Acetate	40-76	estrogen receptor 1	Homo sapiens	86-103
7559663-1	1995	The effects of long term treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) on estrogen receptor (ER) expression in the human breast cancer cell line, MCF-7, were studied.	Tetradecanoylphorbol Acetate	40-76	estrogen receptor 1	Homo sapiens	105-107
7559663-1	1995	The effects of long term treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) on estrogen receptor (ER) expression in the human breast cancer cell line, MCF-7, were studied.	Tetradecanoylphorbol Acetate	78-81	estrogen receptor 1	Homo sapiens	86-103
7559663-1	1995	The effects of long term treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) on estrogen receptor (ER) expression in the human breast cancer cell line, MCF-7, were studied.	Tetradecanoylphorbol Acetate	78-81	estrogen receptor 1	Homo sapiens	105-107
7559663-3	1995	Treatment of cells with 100 nM TPA resulted in an 80% decrease in the level of ER protein and a parallel decrease in ER mRNA and binding capacity.	Tetradecanoylphorbol Acetate	31-34	estrogen receptor 1	Homo sapiens	79-81
7559663-3	1995	Treatment of cells with 100 nM TPA resulted in an 80% decrease in the level of ER protein and a parallel decrease in ER mRNA and binding capacity.	Tetradecanoylphorbol Acetate	31-34	estrogen receptor 1	Homo sapiens	117-119
7559663-4	1995	Following removal of TPA from the medium, the level of ER protein and mRNA returned to control values; however, the receptor failed to bind estradiol.	Tetradecanoylphorbol Acetate	21-24	estrogen receptor 1	Homo sapiens	55-57
7559663-6	1995	In addition, TPA treatment blocked transcription from an estrogen response element in transient transfection assays and inhibited ER binding to its response element in a DNA mobility shift assay.	Tetradecanoylphorbol Acetate	13-16	estrogen receptor 1	Homo sapiens	130-132
7559663-9	1995	Mixing experiments suggest that TPA induces/activates a factor which interacts with the ER to block binding of estradiol.	Tetradecanoylphorbol Acetate	32-35	estrogen receptor 1	Homo sapiens	88-90
7559663-10	1995	The effects of TPA on ER levels and binding capacity were concentration-dependent.	Tetradecanoylphorbol Acetate	15-18	estrogen receptor 1	Homo sapiens	22-24
7488237-2	1995	The increases in activities of both protein tyrosine phosphatase (PTP) and protein tyrosine kinase (PTK) have been reported to be associated with the TPA-induced differentiation of HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	150-153	EPH receptor A8	Homo sapiens	100-103
7488237-5	1995	On the other hand, although TPA induced a transient slight increase in PTK activity (1.4-fold) at 60 min, four PTK inhibitors (genistein, herbimycin A, tyrphostin-23 and quercetin) had different effects on the TPA-induced release of cell surface proteoglycan.	Tetradecanoylphorbol Acetate	28-31	EPH receptor A8	Homo sapiens	71-74
7592595-4	1995	The protein kinase C inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H7), prevented the increase in MT-1 transcription by heme-hemopexin, CoPP-hemopexin, or phorbol 12-myristate 13-acetate, but the protein kinase A inhibitor, HA1004, was without effect.	Tetradecanoylphorbol Acetate	183-214	metallothionein 1	Mus musculus	126-130
7592595-5	1995	N-Acetylcysteine (NAC) and glutathione, as well as superoxide dismutase and catalase, inhibited both the increase in endogenous MT-1 mRNA and the activation of reporter gene activity by heme-hemopexin, CoPP-hemopexin, and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	222-253	metallothionein 1	Mus musculus	128-132
7592669-5	1995	Under these conditions, activation of NF-kappa B by the cell-permeant C2- ceramide (N-acetylsphingosine), by exogenous sphingomyelinase or by phorbol myristate acetate was also inhibited.	Tetradecanoylphorbol Acetate	142-167	nuclear factor kappa B subunit 1	Homo sapiens	38-48
7488237-7	1995	Taken together, these observations suggest that both PTP and PTK activities were increased in SW620 cells in response to TPA; however, the activation of PTP seems to be preferentially required for the TPA-induced differentiation of SW620 human colon cancer cells.	Tetradecanoylphorbol Acetate	121-124	EPH receptor A8	Homo sapiens	61-64
7589454-6	1995	Prolonged exposure of mesangial cells to phorbol myristate acetic acid (PMA) inhibited the enzymatic activity of PKC alpha but not PKC zeta.	Tetradecanoylphorbol Acetate	72-75	protein kinase C alpha	Homo sapiens	113-122
7485512-8	1995	Gln and phorbol 12-myristate 13-acetate stimulated ODC in a synergistic manner.	Tetradecanoylphorbol Acetate	8-39	ornithine decarboxylase 1	Sus scrofa	51-54
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Tetradecanoylphorbol Acetate	184-187	C-X-C motif chemokine ligand 8	Homo sapiens	161-165
7670094-5	1995	Pretreatment of HL-60 cells with all of the agents confers inducibility of cathepsin L (ctsl) mRNA by TPA in previously unresponsive cells.	Tetradecanoylphorbol Acetate	102-105	cathepsin L	Homo sapiens	75-86
7670097-2	1995	We observed that both interleukin-1 (IL-1) and 12-O-tetradecanoylphorbol-13-acetate (TPA) can stimulate the expression of IL-11 and granulocyte-macrophage colony-stimulating factor (GM-CSF) genes in a primate bone marrow stromal fibroblast cell line, PU-34.	Tetradecanoylphorbol Acetate	47-83	interleukin-11	Macaca fascicularis	122-127
7670097-2	1995	We observed that both interleukin-1 (IL-1) and 12-O-tetradecanoylphorbol-13-acetate (TPA) can stimulate the expression of IL-11 and granulocyte-macrophage colony-stimulating factor (GM-CSF) genes in a primate bone marrow stromal fibroblast cell line, PU-34.	Tetradecanoylphorbol Acetate	85-88	interleukin-11	Macaca fascicularis	122-127
7670097-3	1995	We also found that IL-1 or TPA-stimulated IL-11 and GM-CSF expression in PU-34 cells can be abolished by heparin, a class of molecules related to extracellular matrix components, glycosaminoglycans.	Tetradecanoylphorbol Acetate	27-30	interleukin-11	Macaca fascicularis	42-47
7586169-11	1995	Western blot analyses of TPA-treated WB-F344 or C10 cells revealed the presence of a hyperphosphorylated form of Cx43 (Cx43-P3) and no reduction in Cx43-P2, in contrast to BHT-treated cells.	Tetradecanoylphorbol Acetate	25-28	gap junction protein, alpha 1	Rattus norvegicus	113-117
7586169-11	1995	Western blot analyses of TPA-treated WB-F344 or C10 cells revealed the presence of a hyperphosphorylated form of Cx43 (Cx43-P3) and no reduction in Cx43-P2, in contrast to BHT-treated cells.	Tetradecanoylphorbol Acetate	25-28	gap junction protein, alpha 1	Rattus norvegicus	119-126
7586169-11	1995	Western blot analyses of TPA-treated WB-F344 or C10 cells revealed the presence of a hyperphosphorylated form of Cx43 (Cx43-P3) and no reduction in Cx43-P2, in contrast to BHT-treated cells.	Tetradecanoylphorbol Acetate	25-28	gap junction protein, alpha 1	Rattus norvegicus	119-123
7554401-5	1995	Importantly, the levels of mRNA encoding c-myc, IL-2R alpha, IL-2 and IFN-gamma were markedly decreased in patient lymphocytes stimulated with PMA+ionomycin as compared to control lymphocytes.	Tetradecanoylphorbol Acetate	143-146	interleukin 2	Homo sapiens	48-52
7554401-5	1995	Importantly, the levels of mRNA encoding c-myc, IL-2R alpha, IL-2 and IFN-gamma were markedly decreased in patient lymphocytes stimulated with PMA+ionomycin as compared to control lymphocytes.	Tetradecanoylphorbol Acetate	143-146	interferon gamma	Homo sapiens	70-79
8690166-6	1995	However, the expression of these proteins was normal and p44mapk activity remained responsive to the tumour promoter TPA.	Tetradecanoylphorbol Acetate	117-120	mitogen-activated protein kinase 3	Homo sapiens	57-64
7548140-3	1995	Treatment of cells with serum-free media containing epidermal growth factor (EGF), transforming growth factor alpha (TGF alpha), or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA), stimulated system y+ arginine transport activity in Caco-2 cells.	Tetradecanoylphorbol Acetate	169-205	proline rich transmembrane protein 2	Homo sapiens	136-152
7548140-3	1995	Treatment of cells with serum-free media containing epidermal growth factor (EGF), transforming growth factor alpha (TGF alpha), or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA), stimulated system y+ arginine transport activity in Caco-2 cells.	Tetradecanoylphorbol Acetate	169-205	proline rich transmembrane protein 2	Homo sapiens	154-157
7548140-4	1995	Transport upregulation by these growth factors or by TPA was blocked by cycloheximide or the PKC inhibitor chelerythrine.	Tetradecanoylphorbol Acetate	53-56	proline rich transmembrane protein 2	Homo sapiens	93-96
8519449-8	1995	RESULTS: Rolipram inhibited TNF-alpha production in LPS- and phorbol myristate acetate (PMA)-stimulated PBMC and in PMA-stimulated U1 cells.	Tetradecanoylphorbol Acetate	61-86	tumor necrosis factor	Homo sapiens	28-37
8519449-8	1995	RESULTS: Rolipram inhibited TNF-alpha production in LPS- and phorbol myristate acetate (PMA)-stimulated PBMC and in PMA-stimulated U1 cells.	Tetradecanoylphorbol Acetate	88-91	tumor necrosis factor	Homo sapiens	28-37
7485529-5	1995	The treatment of PAEM with the PKC activator phorbol 12-myristate 13-acetate (PMA, 1 microM) induced similar alterations in luminol and glutathione as TNF.	Tetradecanoylphorbol Acetate	45-76	tumor necrosis factor	Homo sapiens	151-154
7485529-5	1995	The treatment of PAEM with the PKC activator phorbol 12-myristate 13-acetate (PMA, 1 microM) induced similar alterations in luminol and glutathione as TNF.	Tetradecanoylphorbol Acetate	78-81	tumor necrosis factor	Homo sapiens	151-154
8547073-4	1995	Our tests showed that IL-2 was produced when leukaemic B cells were stimulated with phorbol myristate acetate, ionomycin and lipopolysaccharide.	Tetradecanoylphorbol Acetate	84-109	interleukin 2	Homo sapiens	22-26
7671257-11	1995	Additionally, in contrast to the parental or control-transfected cell lines, LNCaP/bcl-2 cells were highly resistant to a variety of apoptotic stimuli in vitro including serum starvation and 10 nM phorbol ester (phorbol 12-myristate 13-acetate) supplementation of the medium.	Tetradecanoylphorbol Acetate	212-243	BCL2 apoptosis regulator	Homo sapiens	83-88
7664644-6	1995	Activation of protein kinase A or protein kinase C with forskolin or phorbol 12-myristate 13-acetate also increased PTH/PTHrP receptor phosphorylation, but to a lesser degree than PTH.	Tetradecanoylphorbol Acetate	69-100	parathyroid hormone 1 receptor	Homo sapiens	116-134
7664644-6	1995	Activation of protein kinase A or protein kinase C with forskolin or phorbol 12-myristate 13-acetate also increased PTH/PTHrP receptor phosphorylation, but to a lesser degree than PTH.	Tetradecanoylphorbol Acetate	69-100	parathyroid hormone	Homo sapiens	116-119
8543370-4	1995	The phorbol, 12-myristate 13-acetate (PMA), known to stimulate protein kinase C (PKC), also induced expression of COX-2 mRNA.	Tetradecanoylphorbol Acetate	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Tetradecanoylphorbol Acetate	147-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
7560079-5	1995	TPA-treated MCF-7 cells demonstrated a modest cytostatic response associated with a G1 arrest that was accompanied by Cip1 expression and retinoblastoma hypophosphorylation.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	118-122
7559807-6	1995	Phosphorylation may not act directly on latent transcription factors, since bromophenacyl bromide, an inhibitor for the release of arachidonic acid from phorbol-12 myristate 13-acetate (PMA)-stimulated HL 60 cells, markedly depressed the induced mRNAs for IL-8, TNF-alpha, and IL-1 alpha and -beta.	Tetradecanoylphorbol Acetate	186-189	C-X-C motif chemokine ligand 8	Homo sapiens	256-260
7559807-6	1995	Phosphorylation may not act directly on latent transcription factors, since bromophenacyl bromide, an inhibitor for the release of arachidonic acid from phorbol-12 myristate 13-acetate (PMA)-stimulated HL 60 cells, markedly depressed the induced mRNAs for IL-8, TNF-alpha, and IL-1 alpha and -beta.	Tetradecanoylphorbol Acetate	186-189	tumor necrosis factor	Homo sapiens	262-271
7560079-6	1995	While p53 was detected in MCF-7 cells, evidence for TPA-induced stimulation of p53 transcriptional activity was not evident.	Tetradecanoylphorbol Acetate	52-55	tumor protein p53	Homo sapiens	79-82
7560079-7	1995	In contrast, TPA treatment induced death of MCF-7-PKC-alpha cells.	Tetradecanoylphorbol Acetate	13-16	protein kinase C alpha	Homo sapiens	50-59
7560079-9	1995	TPA-treated MCF-7-PKC-alpha cells accumulated in G2/M, did not express p53, displayed decreased Cip1 expression, and demonstrated a reduction in retinoblastoma hypophosphorylation.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	18-27
7560079-9	1995	TPA-treated MCF-7-PKC-alpha cells accumulated in G2/M, did not express p53, displayed decreased Cip1 expression, and demonstrated a reduction in retinoblastoma hypophosphorylation.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	96-100
7560079-10	1995	TPA-treated MCF-7-PKC-alpha cells expressed gadd-45 which occurred before the onset of apoptosis.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	18-27
8584140-11	1995	CCK mRNA levels in SK-N-MCIXC cells treated with retinoic acid combined with either isoproterenol or phorbol-12-myristate-13 acetate, were not significantly different from cells treated with retinoic acid alone.	Tetradecanoylphorbol Acetate	101-132	cholecystokinin	Homo sapiens	0-3
7500645-2	1995	Treatment of U-937 cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA) which is associated with the induction of a monocytic differentiation program and growth arrest, revealed an initial up-regulation of c-myc, c-max, and mxi1 mRNAs after 1-6 h. Thereafter expression of these genes significantly declined to barely detectable levels when the cells ceased to grow after 12-24 h of TPA treatment.	Tetradecanoylphorbol Acetate	30-67	MAX interactor 1, dimerization protein	Homo sapiens	226-230
7500645-2	1995	Treatment of U-937 cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA) which is associated with the induction of a monocytic differentiation program and growth arrest, revealed an initial up-regulation of c-myc, c-max, and mxi1 mRNAs after 1-6 h. Thereafter expression of these genes significantly declined to barely detectable levels when the cells ceased to grow after 12-24 h of TPA treatment.	Tetradecanoylphorbol Acetate	69-72	MAX interactor 1, dimerization protein	Homo sapiens	226-230
7500645-3	1995	Between 7 and 11 days of TPA-induced G0/G1 cell cycle arrest, expression of the c-max and mxi1 genes continuously increased up to 8-fold until 32 days and declined to control levels when the cells regained proliferative capacity by 36 days.	Tetradecanoylphorbol Acetate	25-28	MAX interactor 1, dimerization protein	Homo sapiens	90-94
7565683-2	1995	Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide.	Tetradecanoylphorbol Acetate	249-274	NFKB inhibitor alpha	Homo sapiens	36-51
7565683-2	1995	Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide.	Tetradecanoylphorbol Acetate	249-274	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	165-180
7565683-2	1995	Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity, such as phorbol myristate acetate or lipopolysaccharide.	Tetradecanoylphorbol Acetate	249-274	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	220-230
7552526-9	1995	IL-1 beta suppressed production of uPA and tPA in both types of SMCs.	Tetradecanoylphorbol Acetate	43-46	interleukin 1 beta	Homo sapiens	0-9
7545243-4	1995	68:1962-1968, 1994), it was found that phorbol myristate acetate (PMA) inhibits human immunodeficiency virus type 1 envelope-mediated cell fusion by inducing down modulation of an accessory component(s) in the CD4-expressing cells.	Tetradecanoylphorbol Acetate	39-64	CD4 molecule	Homo sapiens	210-213
7545243-4	1995	68:1962-1968, 1994), it was found that phorbol myristate acetate (PMA) inhibits human immunodeficiency virus type 1 envelope-mediated cell fusion by inducing down modulation of an accessory component(s) in the CD4-expressing cells.	Tetradecanoylphorbol Acetate	66-69	CD4 molecule	Homo sapiens	210-213
7565683-7	1995	We propose that treatment of 70Z/3 cells with either phorbol myristate acetate or lipopolysaccharide induces a kinase activity which phosphorylates serines 32 and that these phosphorylations target the protein for rapid proteolytic degradation, possibly by the ubiquitin-26S proteasome pathway, thus allowing NF-kappa B to translocate to the nucleus and to activate gene expression.	Tetradecanoylphorbol Acetate	53-78	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	309-319
7672124-1	1995	The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types.	Tetradecanoylphorbol Acetate	19-50	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-141
7569774-2	1995	Phorbol myristate acetate (PMA) rapidly stimulated release of soluble forms of both TNF-receptors.	Tetradecanoylphorbol Acetate	0-25	tumor necrosis factor	Homo sapiens	84-87
7569774-2	1995	Phorbol myristate acetate (PMA) rapidly stimulated release of soluble forms of both TNF-receptors.	Tetradecanoylphorbol Acetate	27-30	tumor necrosis factor	Homo sapiens	84-87
7568092-3	1995	alpha PKC is involved in phorbol 12-myristate 13-acetate-induced cytostasis and megakaryocytic differentiation, whereas beta II PKC is required for proliferation.	Tetradecanoylphorbol Acetate	25-56	protein kinase C alpha	Homo sapiens	6-9
7545713-12	1995	However, IL-13 also directly inhibited monokine secretion, because it blocked PMA-induced, CD14-independent TNF-alpha release.	Tetradecanoylphorbol Acetate	78-81	interleukin 13	Homo sapiens	9-14
7545713-12	1995	However, IL-13 also directly inhibited monokine secretion, because it blocked PMA-induced, CD14-independent TNF-alpha release.	Tetradecanoylphorbol Acetate	78-81	tumor necrosis factor	Homo sapiens	108-117
7559457-4	1995	We now demonstrate that anti-integrin antibody- or phorbol 12-myristate 13-acetate (PMA)-induced activation of the alpha 2 beta 1 integrin on Jurkat cells, as determined by stimulation of adhesion to collagen type I, resulted in an increased amount of calreticulin bound to this integrin.	Tetradecanoylphorbol Acetate	51-82	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	123-129
7559457-4	1995	We now demonstrate that anti-integrin antibody- or phorbol 12-myristate 13-acetate (PMA)-induced activation of the alpha 2 beta 1 integrin on Jurkat cells, as determined by stimulation of adhesion to collagen type I, resulted in an increased amount of calreticulin bound to this integrin.	Tetradecanoylphorbol Acetate	51-82	calreticulin	Homo sapiens	252-264
7559457-4	1995	We now demonstrate that anti-integrin antibody- or phorbol 12-myristate 13-acetate (PMA)-induced activation of the alpha 2 beta 1 integrin on Jurkat cells, as determined by stimulation of adhesion to collagen type I, resulted in an increased amount of calreticulin bound to this integrin.	Tetradecanoylphorbol Acetate	84-87	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	123-129
7559457-4	1995	We now demonstrate that anti-integrin antibody- or phorbol 12-myristate 13-acetate (PMA)-induced activation of the alpha 2 beta 1 integrin on Jurkat cells, as determined by stimulation of adhesion to collagen type I, resulted in an increased amount of calreticulin bound to this integrin.	Tetradecanoylphorbol Acetate	84-87	calreticulin	Homo sapiens	252-264
8554902-7	1995	DFO also protected against PMA-induced NF-kappa B activation as well as TNF-alpha-induced HIV-1 activation.	Tetradecanoylphorbol Acetate	27-30	nuclear factor kappa B subunit 1	Homo sapiens	39-49
7672124-1	1995	The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types.	Tetradecanoylphorbol Acetate	19-50	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	143-146
7672124-1	1995	The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types.	Tetradecanoylphorbol Acetate	52-55	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-141
7672124-1	1995	The tumor promoter phorbol 12-myristate 13-acetate (PMA) and hormonal activators of protein kinase C (PKC) commonly stimulate phospholipase D (PLD)-mediated formation of phosphatidic acid from phosphatidylcholine (PtdCho) in fibroblasts and other cell types.	Tetradecanoylphorbol Acetate	52-55	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	143-146
7654391-3	1995	The lipoxygenase inhibitors, nordihydroguaiaretic acid and diethylcarbamazine, and phospholipase A2 inhibitors, mepacrine and dibucaine, blocked the release of NCA in response to ETX, OZ, calcium ionophore A23187 (A23187), and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	227-252	phospholipase A2 group IB	Homo sapiens	83-99
7654391-3	1995	The lipoxygenase inhibitors, nordihydroguaiaretic acid and diethylcarbamazine, and phospholipase A2 inhibitors, mepacrine and dibucaine, blocked the release of NCA in response to ETX, OZ, calcium ionophore A23187 (A23187), and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	254-257	phospholipase A2 group IB	Homo sapiens	83-99
8861714-4	1995	Phorbol 12-myristate 13-acetate (10(-9) - 3 x 10(-6) M) produced a concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but enhanced nitrite accumulation when added 12 hours following stimulation with LPS and IFN-gamma.	Tetradecanoylphorbol Acetate	0-31	interferon gamma	Homo sapiens	271-280
8536940-5	1995	In Experiment 2, the addition of 10(-12), 10(-10), 10(-8), and 10(-6) M phorbol 12-myristate 13-acetate (PMA; PKC agonist) increased PRL release from 8.5 +/- 0.7 to 14.9 +/- 1.1, 17.2 +/- 1.3, 18.1 +/- 2.2, and 18.7 +/- 2.8 micrograms/10(6) cells, respectively.	Tetradecanoylphorbol Acetate	72-103	prolactin	Meleagris gallopavo	133-136
8861714-4	1995	Phorbol 12-myristate 13-acetate (10(-9) - 3 x 10(-6) M) produced a concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but enhanced nitrite accumulation when added 12 hours following stimulation with LPS and IFN-gamma.	Tetradecanoylphorbol Acetate	0-31	interferon gamma	Homo sapiens	171-180
7544577-5	1995	Phorbol 12-myristate 13-acetate (PMA), a direct activator of protein kinase C, also increased PLD activity.	Tetradecanoylphorbol Acetate	0-31	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	94-97
7544577-5	1995	Phorbol 12-myristate 13-acetate (PMA), a direct activator of protein kinase C, also increased PLD activity.	Tetradecanoylphorbol Acetate	33-36	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	94-97
8845811-1	1995	Benzylphthalimide analogs (P1P"s) and phenethylphthalimide analogs (P2P"s) have been found to exhibit thalidomide-like activity on the production of tumor necrosis factor (TNF)-alpha by the human leukemia cell line, HL-60, stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	237-273	tumor necrosis factor	Homo sapiens	149-182
8845811-1	1995	Benzylphthalimide analogs (P1P"s) and phenethylphthalimide analogs (P2P"s) have been found to exhibit thalidomide-like activity on the production of tumor necrosis factor (TNF)-alpha by the human leukemia cell line, HL-60, stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	275-278	tumor necrosis factor	Homo sapiens	149-182
8519690-5	1995	The PKC agonist 12-O-tetradecanoyl-phorbol-13-acetate (TPA) caused concentration-dependent increases in T5 cell thymidine incorporation.	Tetradecanoylphorbol Acetate	16-53	protein kinase C, alpha	Mus musculus	4-7
8519690-5	1995	The PKC agonist 12-O-tetradecanoyl-phorbol-13-acetate (TPA) caused concentration-dependent increases in T5 cell thymidine incorporation.	Tetradecanoylphorbol Acetate	55-58	protein kinase C, alpha	Mus musculus	4-7
8519690-8	1995	Either 12 or 24 h treatment with 200 or 2000 ng/ml TPA caused complete PKC alpha and partial PKC delta down-regulation in C3, T5, and NRK cells.	Tetradecanoylphorbol Acetate	51-54	protein kinase C, alpha	Mus musculus	71-80
7649093-11	1995	The effect of GHRH on GHF-1 mRNA levels could be mimicked by direct activators of second messenger signaling systems such as forskolin (10(-5) M) or the phorbol ester tumor promoter tetradecanoyl phorbol acetate (TPA) (10(-6) M).	Tetradecanoylphorbol Acetate	213-216	POU class 1 homeobox 1	Rattus norvegicus	22-27
7544757-4	1995	Our results showed that U937 cells secreted TNF-alpha and IL-1 beta in response to either phorbyl 12-myristate 13-acetate (PMA) or IFN-gamma + LPS.	Tetradecanoylphorbol Acetate	123-126	tumor necrosis factor	Homo sapiens	44-53
7544757-4	1995	Our results showed that U937 cells secreted TNF-alpha and IL-1 beta in response to either phorbyl 12-myristate 13-acetate (PMA) or IFN-gamma + LPS.	Tetradecanoylphorbol Acetate	123-126	interleukin 1 beta	Homo sapiens	58-67
7544757-5	1995	In contrast, AFP significantly suppressed PMA-induced TNF-alpha and IL-1 beta production by U937 cells in a time and dose dependent fashion.	Tetradecanoylphorbol Acetate	42-45	alpha fetoprotein	Homo sapiens	13-16
7544757-5	1995	In contrast, AFP significantly suppressed PMA-induced TNF-alpha and IL-1 beta production by U937 cells in a time and dose dependent fashion.	Tetradecanoylphorbol Acetate	42-45	tumor necrosis factor	Homo sapiens	54-63
7544757-5	1995	In contrast, AFP significantly suppressed PMA-induced TNF-alpha and IL-1 beta production by U937 cells in a time and dose dependent fashion.	Tetradecanoylphorbol Acetate	42-45	interleukin 1 beta	Homo sapiens	68-77
7544757-9	1995	PMA-induced prostaglandin E2 (PGE2) production by U937 cells was enhanced by AFP.	Tetradecanoylphorbol Acetate	0-3	alpha fetoprotein	Homo sapiens	77-80
7544757-0	1995	Downregulation of phorbol 12-myristate 13-acetate-induced tumor necrosis factor-alpha and interleukin-1 beta production and gene expression in human monocytic cells by human alpha-fetoprotein.	Tetradecanoylphorbol Acetate	18-49	interleukin 1 beta	Homo sapiens	90-108
7544757-0	1995	Downregulation of phorbol 12-myristate 13-acetate-induced tumor necrosis factor-alpha and interleukin-1 beta production and gene expression in human monocytic cells by human alpha-fetoprotein.	Tetradecanoylphorbol Acetate	18-49	alpha fetoprotein	Homo sapiens	174-191
8536940-6	1995	PRL mRNA abundance was significantly (P &lt; 0.01) increased in only 10(-6) M PMA treatment.	Tetradecanoylphorbol Acetate	78-81	prolactin	Meleagris gallopavo	0-3
7560644-2	1995	The proportions of TCCs from patients with AD producing interleukin-4 in response to stimulation with phorbol 12-myristate 13-acetate plus anti-CD3 antibody were higher, whereas the proportions of interferon-gamma--producing TCCs were lower than those of control subjects.	Tetradecanoylphorbol Acetate	102-133	interleukin 4	Homo sapiens	56-69
7590880-5	1995	Activation of B cells [phorbol myristate acetate (PMA), surface immunoglobulin cross-linking alone or in the presence of interleukin-2 (IL-2)] induced CD44E (variable exon V8-10), R2 (VIO) and CD44 isoforms containing exons V6 and/or V7 (CD44 V6/V7).	Tetradecanoylphorbol Acetate	23-48	interleukin 2	Homo sapiens	136-140
7590880-5	1995	Activation of B cells [phorbol myristate acetate (PMA), surface immunoglobulin cross-linking alone or in the presence of interleukin-2 (IL-2)] induced CD44E (variable exon V8-10), R2 (VIO) and CD44 isoforms containing exons V6 and/or V7 (CD44 V6/V7).	Tetradecanoylphorbol Acetate	23-48	CD101 molecule	Homo sapiens	234-236
7590880-5	1995	Activation of B cells [phorbol myristate acetate (PMA), surface immunoglobulin cross-linking alone or in the presence of interleukin-2 (IL-2)] induced CD44E (variable exon V8-10), R2 (VIO) and CD44 isoforms containing exons V6 and/or V7 (CD44 V6/V7).	Tetradecanoylphorbol Acetate	23-48	CD101 molecule	Homo sapiens	243-248
7636966-3	1995	The virus-induced downregulation of CD4 requires early but not late viral gene expression and could not be inhibited by staurosporine, an inhibitor of protein kinase C, which effectively blocks phorbol 12-myristate-13-acetate-induced downregulation of CD4.	Tetradecanoylphorbol Acetate	194-225	CD4 molecule	Homo sapiens	36-39
7657802-4	1995	During cardiocyte hypertrophy evoked by endothelin-1, Phenylephrine, or PMA, the steady state level of BNP mRNA increased as rapidly as the "immediate-early" induction of the c-fos gene expression, and reached a maximal level within 1 h. Actinomycin D, a transcriptional inhibitor, completely diminished the response, while the translational blocked with cycloheximide did not inhibit it.	Tetradecanoylphorbol Acetate	72-75	natriuretic peptide B	Rattus norvegicus	103-106
8690728-6	1995	The arsenite-induced release of arachidonic acid from cells was also stimulated in the presence of PMA and/or akadaic acid, and the stimulatory effects of PMA and okadaic acid on the arsenite-induced accumulation of alphaB crystallin and hsp27 were strongly suppressed by quinacrine, an inhibitor of phospholipase A2.	Tetradecanoylphorbol Acetate	155-158	phospholipase A2 group IB	Homo sapiens	300-316
7643130-3	1995	This study examines coregulation of SS and NPY by QUIN and NMDA in cultured cortical neurons and compares the effects of these agents with those of forskolin and phorbol 12-myristate 13-acetate (PMA), known to activate SS and NPY gene transcription by protein kinase A- and protein kinase C-dependent mechanisms.	Tetradecanoylphorbol Acetate	162-193	neuropeptide Y	Rattus norvegicus	226-229
7643130-6	1995	In contrast, forskolin and PMA increased both SS and NPY mRNA levels.	Tetradecanoylphorbol Acetate	27-30	neuropeptide Y	Rattus norvegicus	53-56
7636966-3	1995	The virus-induced downregulation of CD4 requires early but not late viral gene expression and could not be inhibited by staurosporine, an inhibitor of protein kinase C, which effectively blocks phorbol 12-myristate-13-acetate-induced downregulation of CD4.	Tetradecanoylphorbol Acetate	194-225	CD4 molecule	Homo sapiens	252-255
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Tetradecanoylphorbol Acetate	165-168	interleukin 1 beta	Homo sapiens	194-212
7646466-2	1995	We have previously found that transforming growth factor-beta, type 1 (TGF-beta 1), increases uPAR gene transcription in the human lung carcinoma cell line A549 and now report that also epidermal growth factor (EGF) and the tumour promoter phorbol 12-myristate 13-acetate (PMA) cause increased uPAR transcription and that PMA and TGF-beta 1 in addition increase the stability of uPAR mRNA, while EGF has no effect on this parameter.	Tetradecanoylphorbol Acetate	240-271	transforming growth factor beta 1	Homo sapiens	30-69
7646466-2	1995	We have previously found that transforming growth factor-beta, type 1 (TGF-beta 1), increases uPAR gene transcription in the human lung carcinoma cell line A549 and now report that also epidermal growth factor (EGF) and the tumour promoter phorbol 12-myristate 13-acetate (PMA) cause increased uPAR transcription and that PMA and TGF-beta 1 in addition increase the stability of uPAR mRNA, while EGF has no effect on this parameter.	Tetradecanoylphorbol Acetate	240-271	transforming growth factor beta 1	Homo sapiens	71-81
7642554-2	1995	Within minutes of phorbol 12-myristate 13-acetate treatment, epidermal growth factor receptor and HER2 tyrosine phosphorylation was decreased, while platelet-derived growth factor receptor and insulin receptor autophosphorylation was upregulated.	Tetradecanoylphorbol Acetate	18-49	receptor-like tyrosine kinase	Mus musculus	71-93
7642554-4	1995	In contrast to these short term effects, sustained activation of protein kinase C alpha by phorbol 12-myristate 13-acetate results in translocation of protein kinase C from the cytosol to the membrane fraction where it forms stable complexes with all receptor tyrosine kinases investigated.	Tetradecanoylphorbol Acetate	91-122	protein kinase C, alpha	Mus musculus	65-87
7629197-3	1995	This was confirmed by the ability of the PKC activator phorbol 12-myristate 13-acetate (PMA) to produce a similar effect, suggesting a PKC-dependent modulation of beta ARK activity.	Tetradecanoylphorbol Acetate	55-86	proline rich transmembrane protein 2	Homo sapiens	41-44
7629197-3	1995	This was confirmed by the ability of the PKC activator phorbol 12-myristate 13-acetate (PMA) to produce a similar effect, suggesting a PKC-dependent modulation of beta ARK activity.	Tetradecanoylphorbol Acetate	55-86	proline rich transmembrane protein 2	Homo sapiens	135-138
7629197-3	1995	This was confirmed by the ability of the PKC activator phorbol 12-myristate 13-acetate (PMA) to produce a similar effect, suggesting a PKC-dependent modulation of beta ARK activity.	Tetradecanoylphorbol Acetate	88-91	proline rich transmembrane protein 2	Homo sapiens	41-44
7629197-3	1995	This was confirmed by the ability of the PKC activator phorbol 12-myristate 13-acetate (PMA) to produce a similar effect, suggesting a PKC-dependent modulation of beta ARK activity.	Tetradecanoylphorbol Acetate	88-91	proline rich transmembrane protein 2	Homo sapiens	135-138
7629197-6	1995	The level of phosphorylation of beta ARK1 immunoprecipitated from MNL and Sf9 cells overexpressing this kinase was enhanced by about 2-3-fold after PMA treatment.	Tetradecanoylphorbol Acetate	148-151	G protein-coupled receptor kinase 2	Homo sapiens	32-41
7634409-6	1995	Examination of the mechanism of action of these redox-active compounds demonstrated correlations between their abilities to (i) prevent TPA-induced downregulation of GJIC, (ii) abolish the accumulation of intracellular oxidants and (iii) prevent the hyper-phosphorylation and internalization of connexin 43 in the cells.	Tetradecanoylphorbol Acetate	136-139	gap junction protein, alpha 1	Rattus norvegicus	295-306
8588973-3	1995	Pretreatment of TSMCs with phorbol 12-myristate 13-acetate (PMA, 1 microM) for 30 min blocked the BK-induced IP3 formation and Ca2+ mobilization.	Tetradecanoylphorbol Acetate	27-58	kininogen 1	Canis lupus familiaris	98-100
8588973-3	1995	Pretreatment of TSMCs with phorbol 12-myristate 13-acetate (PMA, 1 microM) for 30 min blocked the BK-induced IP3 formation and Ca2+ mobilization.	Tetradecanoylphorbol Acetate	60-63	kininogen 1	Canis lupus familiaris	98-100
8588973-6	1995	Prior treatment with staurosporine (1 microM), a PKC inhibitor, inhibited the effect of PMA on the BK-induced response, suggesting that the effect of PMA is mediated by the activation of PKC.	Tetradecanoylphorbol Acetate	88-91	kininogen 1	Canis lupus familiaris	99-101
8588976-2	1995	In [3H]myristate-labelled endometrial stromal cells, bradykinin and tetradecanoylphorbol acetate (TPA) mediated activation of phospholipase D (PLD) as measured by the accumulation of [3H]phosphatidylbutanol ([3H]PtdBut).	Tetradecanoylphorbol Acetate	68-96	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-141
8588976-2	1995	In [3H]myristate-labelled endometrial stromal cells, bradykinin and tetradecanoylphorbol acetate (TPA) mediated activation of phospholipase D (PLD) as measured by the accumulation of [3H]phosphatidylbutanol ([3H]PtdBut).	Tetradecanoylphorbol Acetate	68-96	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	143-146
8588976-2	1995	In [3H]myristate-labelled endometrial stromal cells, bradykinin and tetradecanoylphorbol acetate (TPA) mediated activation of phospholipase D (PLD) as measured by the accumulation of [3H]phosphatidylbutanol ([3H]PtdBut).	Tetradecanoylphorbol Acetate	98-101	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-141
8588976-2	1995	In [3H]myristate-labelled endometrial stromal cells, bradykinin and tetradecanoylphorbol acetate (TPA) mediated activation of phospholipase D (PLD) as measured by the accumulation of [3H]phosphatidylbutanol ([3H]PtdBut).	Tetradecanoylphorbol Acetate	98-101	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	143-146
8588976-6	1995	Chronic pretreatment with 400 nM TPA abolished PLD activation to subsequent treatment with either TPA and bradykinin.	Tetradecanoylphorbol Acetate	33-36	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	47-50
8588976-6	1995	Chronic pretreatment with 400 nM TPA abolished PLD activation to subsequent treatment with either TPA and bradykinin.	Tetradecanoylphorbol Acetate	33-36	kininogen 1	Homo sapiens	106-116
7628383-5	1995	Treatment of the granulosa cells with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, progressively decreased the number of bFGF receptors to about 20% of their initial levels after 8 h, and this effect occurred in a concentration- and time-dependent manner.	Tetradecanoylphorbol Acetate	38-69	fibroblast growth factor 2	Homo sapiens	151-155
7628383-5	1995	Treatment of the granulosa cells with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, progressively decreased the number of bFGF receptors to about 20% of their initial levels after 8 h, and this effect occurred in a concentration- and time-dependent manner.	Tetradecanoylphorbol Acetate	71-74	fibroblast growth factor 2	Homo sapiens	151-155
7628383-7	1995	The highly specific PKC inhibitor GF109203X completely prevented the reduction of bFGF binding by PMA and diacylglycerol.	Tetradecanoylphorbol Acetate	98-101	fibroblast growth factor 2	Homo sapiens	82-86
7664781-3	1995	In the present study we analyzed the control of IL-2 promoter activity in Epstein-Barr virus (EBV)-transformed B cell clones which are capable of secreting IL-2 at a low level after stimulation with phorbol 12-myristate 13-acetate and the Ca2+ ionophore ionomycin.	Tetradecanoylphorbol Acetate	199-230	interleukin 2	Homo sapiens	48-52
7664781-3	1995	In the present study we analyzed the control of IL-2 promoter activity in Epstein-Barr virus (EBV)-transformed B cell clones which are capable of secreting IL-2 at a low level after stimulation with phorbol 12-myristate 13-acetate and the Ca2+ ionophore ionomycin.	Tetradecanoylphorbol Acetate	199-230	interleukin 2	Homo sapiens	156-160
11725057-7	1995	Both the AP-1/AP-2/SP-1 dyad protein binding region and, to a lesser extent, the YY1 tandem-repeat cluster conferred responsiveness to TPA when placed upstream of a heterologous promoter in transient expression assays.	Tetradecanoylphorbol Acetate	135-138	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	9-13
11725057-7	1995	Both the AP-1/AP-2/SP-1 dyad protein binding region and, to a lesser extent, the YY1 tandem-repeat cluster conferred responsiveness to TPA when placed upstream of a heterologous promoter in transient expression assays.	Tetradecanoylphorbol Acetate	135-138	YY1 transcription factor	Homo sapiens	81-84
7543547-6	1995	PMA stimulated the production of collagenase, stromelysin, 92-kDa gelatinase, and TIMP-1 in both endothelial cell types.	Tetradecanoylphorbol Acetate	0-3	TIMP metallopeptidase inhibitor 1	Homo sapiens	82-88
7616276-7	1995	Interstitial collagenase, gelatinase B, stromelysin, and TIMP-1 genes were upregulated in many cell lines by phorbol-12-myristate-13-acetate (PMA) and in some cell lines by epidermal growth factor, tumor necrosis factor-alpha, or interleukin-1 beta.	Tetradecanoylphorbol Acetate	109-140	TIMP metallopeptidase inhibitor 1	Homo sapiens	57-63
7616276-7	1995	Interstitial collagenase, gelatinase B, stromelysin, and TIMP-1 genes were upregulated in many cell lines by phorbol-12-myristate-13-acetate (PMA) and in some cell lines by epidermal growth factor, tumor necrosis factor-alpha, or interleukin-1 beta.	Tetradecanoylphorbol Acetate	142-145	TIMP metallopeptidase inhibitor 1	Homo sapiens	57-63
7579712-8	1995	Kinetic analysis showed that loss of cell surface proHB-EGF is maximal at 30 min after addition of TPA and that proHB-EGF is resynthesized and the initial cell surface levels are regained within 12-24 h. Loss of cell surface proHB-EGF was concomitant with appearance of 14- and 19-kDa soluble HB-EGF species in conditioned medium.	Tetradecanoylphorbol Acetate	99-102	proheparin-binding EGF-like growth factor	Chlorocebus sabaeus	53-59
7642569-12	1995	Pretreatment of cells with phorbol 12-myristate 13-acetate for 15 min, to activate protein kinase C, resulted in inhibition of the IL-6-induced SIF response (10 min).	Tetradecanoylphorbol Acetate	27-58	interleukin 6	Homo sapiens	131-135
7642584-2	1995	Treatment of differentiated HL60 cells or transiently transfected COS-7 cells with C5a or phorbol 12-myristate 12-acetate (PMA) results in rapid hyperphosphorylation of the C5aR.	Tetradecanoylphorbol Acetate	123-126	complement C5a receptor 1	Homo sapiens	173-177
7646552-5	1995	TPA treatment caused an increase in P-glycoprotein, increased drug resistance and decreased rhodamine-123 accumulation which was verapamil sensitive, demonstrating that TPA induced a fully functional P-glycoprotein.	Tetradecanoylphorbol Acetate	0-3	ATP binding cassette subfamily B member 1	Homo sapiens	36-50
7646552-5	1995	TPA treatment caused an increase in P-glycoprotein, increased drug resistance and decreased rhodamine-123 accumulation which was verapamil sensitive, demonstrating that TPA induced a fully functional P-glycoprotein.	Tetradecanoylphorbol Acetate	0-3	ATP binding cassette subfamily B member 1	Homo sapiens	200-214
7646552-5	1995	TPA treatment caused an increase in P-glycoprotein, increased drug resistance and decreased rhodamine-123 accumulation which was verapamil sensitive, demonstrating that TPA induced a fully functional P-glycoprotein.	Tetradecanoylphorbol Acetate	169-172	ATP binding cassette subfamily B member 1	Homo sapiens	36-50
7646552-5	1995	TPA treatment caused an increase in P-glycoprotein, increased drug resistance and decreased rhodamine-123 accumulation which was verapamil sensitive, demonstrating that TPA induced a fully functional P-glycoprotein.	Tetradecanoylphorbol Acetate	169-172	ATP binding cassette subfamily B member 1	Homo sapiens	200-214
7653527-3	1995	After the activation of protein kinase C (PKC) by phorbol myristate acetate (PMA), NCE activity decreased exponentially by 75% in 48 h (half time approximately 19 h).	Tetradecanoylphorbol Acetate	50-75	protein kinase C alpha	Homo sapiens	42-45
7653527-3	1995	After the activation of protein kinase C (PKC) by phorbol myristate acetate (PMA), NCE activity decreased exponentially by 75% in 48 h (half time approximately 19 h).	Tetradecanoylphorbol Acetate	50-75	solute carrier family 8 member A1	Homo sapiens	83-86
7653527-3	1995	After the activation of protein kinase C (PKC) by phorbol myristate acetate (PMA), NCE activity decreased exponentially by 75% in 48 h (half time approximately 19 h).	Tetradecanoylphorbol Acetate	77-80	protein kinase C alpha	Homo sapiens	42-45
7653527-3	1995	After the activation of protein kinase C (PKC) by phorbol myristate acetate (PMA), NCE activity decreased exponentially by 75% in 48 h (half time approximately 19 h).	Tetradecanoylphorbol Acetate	77-80	solute carrier family 8 member A1	Homo sapiens	83-86
7653527-6	1995	PMA decreased the binding of 3H-labeled antibody to cell sonicates by 40% in 24 h. Immunoblots show that PMA produced a marked and extended increase in membrane-associated PKC-alpha, although PMA depleted total PKC-alpha by 65% in 24 h. In vivo 32P labeling of myristolated alanine-rich C kinase substrate, a specific PKC substrate, confirmed that PMA produced a rapid and extended activation of PKC.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	172-181
7653527-6	1995	PMA decreased the binding of 3H-labeled antibody to cell sonicates by 40% in 24 h. Immunoblots show that PMA produced a marked and extended increase in membrane-associated PKC-alpha, although PMA depleted total PKC-alpha by 65% in 24 h. In vivo 32P labeling of myristolated alanine-rich C kinase substrate, a specific PKC substrate, confirmed that PMA produced a rapid and extended activation of PKC.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	211-220
7653527-6	1995	PMA decreased the binding of 3H-labeled antibody to cell sonicates by 40% in 24 h. Immunoblots show that PMA produced a marked and extended increase in membrane-associated PKC-alpha, although PMA depleted total PKC-alpha by 65% in 24 h. In vivo 32P labeling of myristolated alanine-rich C kinase substrate, a specific PKC substrate, confirmed that PMA produced a rapid and extended activation of PKC.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	172-175
7653527-6	1995	PMA decreased the binding of 3H-labeled antibody to cell sonicates by 40% in 24 h. Immunoblots show that PMA produced a marked and extended increase in membrane-associated PKC-alpha, although PMA depleted total PKC-alpha by 65% in 24 h. In vivo 32P labeling of myristolated alanine-rich C kinase substrate, a specific PKC substrate, confirmed that PMA produced a rapid and extended activation of PKC.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	211-214
8588976-8	1995	The effect of bradykinin and TPA on PLD activity was synergistic, suggesting that the two agents may act via different mechanisms.	Tetradecanoylphorbol Acetate	29-32	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	36-39
21153140-5	1995	Results in the longer term differed, as pretreatment of granulosa cells with CHX for 20 h suppressed the induction of follistatin gene expression by both EGF and phorbol 12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	162-193	follistatin	Homo sapiens	118-129
7622586-9	1995	Although no heat shock element can be identified in the promoter of the bFGF gene, we observed that the AP-1 binding activity to a TPA responsive element (TRE)-like sequence in the promoter of bFGF gene was enhanced by heat, as tested by mobility shift assay.	Tetradecanoylphorbol Acetate	131-134	fibroblast growth factor 2	Homo sapiens	72-76
7622586-9	1995	Although no heat shock element can be identified in the promoter of the bFGF gene, we observed that the AP-1 binding activity to a TPA responsive element (TRE)-like sequence in the promoter of bFGF gene was enhanced by heat, as tested by mobility shift assay.	Tetradecanoylphorbol Acetate	131-134	fibroblast growth factor 2	Homo sapiens	193-197
8543566-6	1995	The addition of phorbol 12-myristate 13-acetate (PMA) or agents elevating the cyclic AMP content, such as vasoactive intestinal peptide (VIP) or an adenosine analog, also stimulated [3H]NA release.	Tetradecanoylphorbol Acetate	16-47	vasoactive intestinal peptide	Rattus norvegicus	137-140
7638727-2	1995	Phorbol myristate acetate (PMA) was found to inhibit both cyclic adenosine monophosphate (cAMP)-regulated Cl secretion and basolateral NKCC function in parallel but not apical Cl channels.	Tetradecanoylphorbol Acetate	0-25	solute carrier family 12 member 1	Homo sapiens	135-139
7638727-2	1995	Phorbol myristate acetate (PMA) was found to inhibit both cyclic adenosine monophosphate (cAMP)-regulated Cl secretion and basolateral NKCC function in parallel but not apical Cl channels.	Tetradecanoylphorbol Acetate	27-30	solute carrier family 12 member 1	Homo sapiens	135-139
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Tetradecanoylphorbol Acetate	165-168	interleukin 1 beta	Homo sapiens	214-223
7542761-5	1995	In both thymocytes and T cells, txk transcripts are down-regulated after activation with PMA and ionomycin, concanavalin A or T cell receptor cross-linking.	Tetradecanoylphorbol Acetate	89-92	TXK tyrosine kinase	Mus musculus	32-35
7605990-6	1995	PEBP2 alpha A1 and alpha B1 enhanced the expression of the GM-CSF promoter-driven reporter plasmid in unstimulated and 12-O-tetradecanoylphorbol 13-acetate/phytohemagglutinin-stimulated human Jurkat T cells.	Tetradecanoylphorbol Acetate	119-155	BCL2 related protein A1	Homo sapiens	12-27
7542871-0	1995	Beta 1 integrins mediate adherent phenotype of human erythroblastic cell lines after phorbol 12-myristate 13-acetate induction.	Tetradecanoylphorbol Acetate	85-116	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	0-6
7542872-6	1995	Direct activation of PKC by phorbol 12-myristate 13-acetate confirmed earlier observations that PGI2-induced cyclic AMP accumulation is partly inhibited via PKC.	Tetradecanoylphorbol Acetate	28-59	proline rich transmembrane protein 2	Homo sapiens	21-24
7542872-6	1995	Direct activation of PKC by phorbol 12-myristate 13-acetate confirmed earlier observations that PGI2-induced cyclic AMP accumulation is partly inhibited via PKC.	Tetradecanoylphorbol Acetate	28-59	proline rich transmembrane protein 2	Homo sapiens	157-160
7542684-4	1995	Furthermore, when PMN were activated with N-formyl-methionylleucyl-phenylalanine or phorbol myristate acetate in the presence of superoxide dismutase (SOD) and catalase, methemoglobin formation ensued.	Tetradecanoylphorbol Acetate	84-109	superoxide dismutase 1	Homo sapiens	151-154
7542684-4	1995	Furthermore, when PMN were activated with N-formyl-methionylleucyl-phenylalanine or phorbol myristate acetate in the presence of superoxide dismutase (SOD) and catalase, methemoglobin formation ensued.	Tetradecanoylphorbol Acetate	84-109	catalase	Homo sapiens	160-168
7630726-5	1995	The activity of the TGT enzyme was restored after treatment of the cells with the protein kinase C activator, TPA, even in the presence of mRNA or protein synthesis inhibitors.	Tetradecanoylphorbol Acetate	110-113	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	20-23
7628641-1	1995	We compared the influence of exogenous N-ras oncogene and treatment with PKC agonist 12-O-tetradecanoylphorbol-13-acetate (TPA) on P-glycoprotein (Pgp) function in various human, rat and dog cell lines.	Tetradecanoylphorbol Acetate	85-121	ATP binding cassette subfamily B member 1	Homo sapiens	131-145
7628641-1	1995	We compared the influence of exogenous N-ras oncogene and treatment with PKC agonist 12-O-tetradecanoylphorbol-13-acetate (TPA) on P-glycoprotein (Pgp) function in various human, rat and dog cell lines.	Tetradecanoylphorbol Acetate	85-121	ATP binding cassette subfamily B member 1	Homo sapiens	147-150
7628641-1	1995	We compared the influence of exogenous N-ras oncogene and treatment with PKC agonist 12-O-tetradecanoylphorbol-13-acetate (TPA) on P-glycoprotein (Pgp) function in various human, rat and dog cell lines.	Tetradecanoylphorbol Acetate	123-126	ATP binding cassette subfamily B member 1	Homo sapiens	131-145
7628641-1	1995	We compared the influence of exogenous N-ras oncogene and treatment with PKC agonist 12-O-tetradecanoylphorbol-13-acetate (TPA) on P-glycoprotein (Pgp) function in various human, rat and dog cell lines.	Tetradecanoylphorbol Acetate	123-126	ATP binding cassette subfamily B member 1	Homo sapiens	147-150
7608556-5	1995	Analysis of signaling pathways showed that PMA and calcium ionophore A23187, but not dibutyryl cAMP, induced COX-2 mRNA.	Tetradecanoylphorbol Acetate	43-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
7632163-3	1995	To clarify this mechanism, the degranulation response was induced by agents known to activate different steps in the activation cascade in PMNs: the receptor-mediated activator fMLP (N-formyl-L-methionyl-L-leucyl-L-phenylalanine); a calcium ionophore (A23187); an inhibitor of calcium-ATPase (thapsigargin); and an activator of protein kinase C (phorbol myristate acetate, PMA).	Tetradecanoylphorbol Acetate	346-371	formyl peptide receptor 1	Homo sapiens	177-181
7541797-7	1995	In the calbindin-expressing cells, phorbol 12-myristate 13-acetate or low phosphate medium, which increased phosphate transport, produced actin filament aggregation, dissociation of the myristoylated alanine-rich C kinase substrate protein from sub-apical actin, and membrane-associated tyrosine phosphate staining.	Tetradecanoylphorbol Acetate	35-66	calbindin 1	Rattus norvegicus	7-16
7795258-4	1995	Downregulation of protein kinase (PK) by a 24-hour incubation in 100 nmol/L 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in the presence of IL-3 dramatically reduced bcl-2 mRNA levels, and induced apoptosis in the presence of IL-3.	Tetradecanoylphorbol Acetate	76-113	BCL2 apoptosis regulator	Homo sapiens	165-170
7795258-4	1995	Downregulation of protein kinase (PK) by a 24-hour incubation in 100 nmol/L 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in the presence of IL-3 dramatically reduced bcl-2 mRNA levels, and induced apoptosis in the presence of IL-3.	Tetradecanoylphorbol Acetate	115-118	BCL2 apoptosis regulator	Homo sapiens	165-170
7606799-4	1995	Phorbol ester (PMA), a direct activator of PKC, provoked LHRH production and cell surface expression of CD69 and IL-2R molecules by T cells, but not IL-2 synthesis.	Tetradecanoylphorbol Acetate	15-18	interleukin 2	Homo sapiens	113-117
7547506-0	1995	Rapid activation and down-regulation of protein kinase C alpha in 12-O-Tetradecanoylphorbol-13-acetate-induced differentiation of human rhabdomyosarcoma cells.	Tetradecanoylphorbol Acetate	66-102	protein kinase C alpha	Homo sapiens	40-62
7547506-2	1995	Prolonged treatment of RD cells with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induces growth arrest and myogenic differentiation as shown by the accumulation of alpha-actin and myosin light and heavy chains, without affecting the expression of MyoD and myogenin.	Tetradecanoylphorbol Acetate	74-110	protein kinase C alpha	Homo sapiens	59-62
7547506-2	1995	Prolonged treatment of RD cells with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induces growth arrest and myogenic differentiation as shown by the accumulation of alpha-actin and myosin light and heavy chains, without affecting the expression of MyoD and myogenin.	Tetradecanoylphorbol Acetate	74-110	myogenic differentiation 1	Homo sapiens	283-287
7547506-2	1995	Prolonged treatment of RD cells with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induces growth arrest and myogenic differentiation as shown by the accumulation of alpha-actin and myosin light and heavy chains, without affecting the expression of MyoD and myogenin.	Tetradecanoylphorbol Acetate	112-115	protein kinase C alpha	Homo sapiens	59-62
7547506-2	1995	Prolonged treatment of RD cells with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induces growth arrest and myogenic differentiation as shown by the accumulation of alpha-actin and myosin light and heavy chains, without affecting the expression of MyoD and myogenin.	Tetradecanoylphorbol Acetate	112-115	myogenic differentiation 1	Homo sapiens	283-287
7547506-4	1995	Furthermore, PKC inhibitors, such as staurosporine or calphostin C, prevent TPA-induced differentiation but not cell growth arrest.	Tetradecanoylphorbol Acetate	76-79	protein kinase C alpha	Homo sapiens	13-16
7547506-9	1995	By immunofluorescence analysis, we show that the PKC alpha down-regulation is specific for those cells that respond to TPA by activating the muscle phenotype.	Tetradecanoylphorbol Acetate	119-122	protein kinase C alpha	Homo sapiens	49-58
7547506-10	1995	We propose that TPA-induced differentiation in RD cells is mediated by the transient activation of PKC alpha, which activates some of the intracellular events that are necessary for MyoD and myogenin transacting activity and for the induction of terminal differentiation of RD cells.	Tetradecanoylphorbol Acetate	16-19	protein kinase C alpha	Homo sapiens	99-108
7547506-10	1995	We propose that TPA-induced differentiation in RD cells is mediated by the transient activation of PKC alpha, which activates some of the intracellular events that are necessary for MyoD and myogenin transacting activity and for the induction of terminal differentiation of RD cells.	Tetradecanoylphorbol Acetate	16-19	myogenic differentiation 1	Homo sapiens	182-186
7547506-11	1995	By contrast, the constitutively active beta 1 and sigma are responsible for the maintenance of cell growth, and their down-regulation is responsible for long-term TPA-induced cell growth arrest.	Tetradecanoylphorbol Acetate	163-166	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	39-55
7606799-5	1995	The synthesis of IL-2 by T cells required costimulation with PMA and ionomycin, a Ca2+ ionophore.	Tetradecanoylphorbol Acetate	61-64	interleukin 2	Homo sapiens	17-21
7789317-3	1995	After prolonged treatment with high concentration of tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA), the protein kinase C-alpha (PKC-alpha) level in the Hep3B cells was diminished and could not be detected by Western blot analysis.	Tetradecanoylphorbol Acetate	69-106	protein kinase C alpha	Homo sapiens	142-151
7583919-4	1995	PMA at a concentration of 50 ng/ml plus 50 ng of calcium ionophore A23187 per ml was used to induce IFN-gamma, while 150 hemagglutinating units of Sendai virus was used to induce IFN-alpha production.	Tetradecanoylphorbol Acetate	0-3	interferon gamma	Homo sapiens	100-103
7557232-3	1995	TPA inhibited proliferation and induced macrophage-like differentiation of primary AML blast cells and these changes were accompanied by modulation of IFN-alpha expression in CM.	Tetradecanoylphorbol Acetate	0-3	interferon alpha 1	Homo sapiens	151-160
7543050-5	1995	For splenocytes and LNL from flight (FLT) animals, IL-2 production decreased in response to the T cell receptor-independent mitogen 12-O-tetradecanoylphorbol-13-acetate plus ionomycin, but was not affected by stimulation with the T cell receptor-dependent mitogens Concanavalin A or phytohemagglutinin.	Tetradecanoylphorbol Acetate	132-168	interleukin 2	Homo sapiens	51-55
7628546-2	1995	All PKC isoenzymes except PKC zeta are down-regulated by TPA as well as by bryostatin.	Tetradecanoylphorbol Acetate	57-60	protein kinase C alpha	Homo sapiens	4-7
7553229-10	1995	Phorbol myristate acetate (PMA) added to the cell cultures increased the accumulation of AG and NR and reversed the inhibitory effect of IFN-gamma.	Tetradecanoylphorbol Acetate	0-25	interferon gamma	Mus musculus	137-146
8530162-5	1995	TPA treatment also caused a profound change in the IFN-gamma activation of GAF and DIF.	Tetradecanoylphorbol Acetate	0-3	interferon gamma	Homo sapiens	51-60
8530162-5	1995	TPA treatment also caused a profound change in the IFN-gamma activation of GAF and DIF.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	83-86
8530162-8	1995	Moreover, DIF activation was observed during TPA-induced monocytic differentiation and after treatment of macrophages with the macrophage differentiation factor CSF-1.	Tetradecanoylphorbol Acetate	45-48	tumor necrosis factor	Homo sapiens	10-13
7790814-8	1995	Similarly, activation of DNA binding by the transcription factor, nuclear factor (NF) kappa B, as assessed by electrophoretic mobility shift assay, occurred in response to LPS stimulation but not in response to delta Raf-1:ER activation or phorbol myristate acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	267-270	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-93
7790814-8	1995	Similarly, activation of DNA binding by the transcription factor, nuclear factor (NF) kappa B, as assessed by electrophoretic mobility shift assay, occurred in response to LPS stimulation but not in response to delta Raf-1:ER activation or phorbol myristate acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	267-270	toll-like receptor 4	Mus musculus	172-175
7578981-0	1995	Changes in the expression of MCP-1 receptors on monocytic THP-1 cells following differentiation to macrophages with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	116-141	mast cell protease 1	Mus musculus	29-34
7578981-7	1995	The reduction in specific binding of MCP-1 by M phi-THP-1 cells was due to a decrease in both receptor number and affinity; receptor number was reduced to 481 +/- 106 receptors/cells with a Kd of 3.16 +/- 0.7 nM on cells treated for 3 h with PMA.	Tetradecanoylphorbol Acetate	242-245	mast cell protease 1	Mus musculus	37-42
7553229-10	1995	Phorbol myristate acetate (PMA) added to the cell cultures increased the accumulation of AG and NR and reversed the inhibitory effect of IFN-gamma.	Tetradecanoylphorbol Acetate	27-30	interferon gamma	Mus musculus	137-146
7615975-3	1995	Transforming growth factor-alpha, epidermal growth factor, and phorbol myristate acetate markedly stimulated VPF/VEGF mRNA expression by cultured keratinocytes; as in psoriatic skin, the three most common VPF/VEGF isoforms (encoding proteins of 121, 165, and 189 amino acids) were upregulated to an equal extent.	Tetradecanoylphorbol Acetate	63-88	vascular endothelial growth factor A	Homo sapiens	109-112
7615975-3	1995	Transforming growth factor-alpha, epidermal growth factor, and phorbol myristate acetate markedly stimulated VPF/VEGF mRNA expression by cultured keratinocytes; as in psoriatic skin, the three most common VPF/VEGF isoforms (encoding proteins of 121, 165, and 189 amino acids) were upregulated to an equal extent.	Tetradecanoylphorbol Acetate	63-88	vascular endothelial growth factor A	Homo sapiens	113-117
7615975-3	1995	Transforming growth factor-alpha, epidermal growth factor, and phorbol myristate acetate markedly stimulated VPF/VEGF mRNA expression by cultured keratinocytes; as in psoriatic skin, the three most common VPF/VEGF isoforms (encoding proteins of 121, 165, and 189 amino acids) were upregulated to an equal extent.	Tetradecanoylphorbol Acetate	63-88	vascular endothelial growth factor A	Homo sapiens	205-208
7615975-3	1995	Transforming growth factor-alpha, epidermal growth factor, and phorbol myristate acetate markedly stimulated VPF/VEGF mRNA expression by cultured keratinocytes; as in psoriatic skin, the three most common VPF/VEGF isoforms (encoding proteins of 121, 165, and 189 amino acids) were upregulated to an equal extent.	Tetradecanoylphorbol Acetate	63-88	vascular endothelial growth factor A	Homo sapiens	209-213
7615975-4	1995	Transforming growth factor (TGF)-alpha, epidermal growth factor, and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion.	Tetradecanoylphorbol Acetate	69-94	vascular endothelial growth factor A	Homo sapiens	126-129
7615975-4	1995	Transforming growth factor (TGF)-alpha, epidermal growth factor, and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion.	Tetradecanoylphorbol Acetate	69-94	vascular endothelial growth factor A	Homo sapiens	130-134
7615975-4	1995	Transforming growth factor (TGF)-alpha, epidermal growth factor, and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion.	Tetradecanoylphorbol Acetate	69-94	interleukin 6	Homo sapiens	224-228
7615975-4	1995	Transforming growth factor (TGF)-alpha, epidermal growth factor, and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion.	Tetradecanoylphorbol Acetate	69-94	C-X-C motif chemokine ligand 8	Homo sapiens	230-234
7615975-4	1995	Transforming growth factor (TGF)-alpha, epidermal growth factor, and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion.	Tetradecanoylphorbol Acetate	69-94	tumor necrosis factor	Homo sapiens	236-263
7541446-5	1995	Treatment with interferon-beta (IFN-beta), platelet-derived growth factor-AA, leukemia inhibitory factor, phorbol 12-myristate 13-acetate, and dibutyryl cyclic AMP stimulated phosphorylation of HSP27 moderately, while IFN-gamma, TNF-beta, basic fibroblast growth factor, epidermal growth factor, or fetal bovine serum did not significantly alter the level of HSP27 phosphorylation.	Tetradecanoylphorbol Acetate	106-137	interferon gamma	Homo sapiens	218-227
7615975-4	1995	Transforming growth factor (TGF)-alpha, epidermal growth factor, and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion.	Tetradecanoylphorbol Acetate	69-94	interferon gamma	Homo sapiens	265-318
7615975-4	1995	Transforming growth factor (TGF)-alpha, epidermal growth factor, and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion.	Tetradecanoylphorbol Acetate	69-94	vascular endothelial growth factor A	Homo sapiens	334-337
7615975-4	1995	Transforming growth factor (TGF)-alpha, epidermal growth factor, and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion.	Tetradecanoylphorbol Acetate	69-94	vascular endothelial growth factor A	Homo sapiens	338-342
7554227-8	1995	To establish that TPA (PKC) regulates assembly of vimentin into the cytoskeleton of astrocytes, we used pulse-chase (20/5 min) labeling with [35S]methionine, and immunoprecipitations with an anti-vimentin mAb from extractable and cytoskeletal fractions.	Tetradecanoylphorbol Acetate	18-21	vimentin	Gallus gallus	50-58
7637390-1	1995	Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells.	Tetradecanoylphorbol Acetate	86-115	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
7637390-1	1995	Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells.	Tetradecanoylphorbol Acetate	86-115	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
7637390-1	1995	Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells.	Tetradecanoylphorbol Acetate	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
7637390-1	1995	Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells.	Tetradecanoylphorbol Acetate	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
7623773-5	1995	With TPA treatment of the cells for various times (10 min, 90 min, 3 hr, 6 hr, or 24 hr), translocation of PKC-alpha and PKC-delta from the cytosol to the membrane was seen after 10- or 90-min treatment and restoration to basal levels in the membrane fraction was seen after 3-hr treatment.	Tetradecanoylphorbol Acetate	5-8	protein kinase C alpha	Homo sapiens	107-116
7623773-10	1995	After 10- or 90-min TPA treatment, AIF4(-)--but not Ca2+ ionophore-induced PI hydrolysis was inhibited, whereas [3H]BK binding was unaffected, indicating that the site of action of PKC-alpha and PKC-delta in the BK receptor/G protein/PLC pathway is after the receptor and before PLC, i.e., the G protein.	Tetradecanoylphorbol Acetate	20-23	itchy E3 ubiquitin protein ligase	Homo sapiens	35-39
7623773-10	1995	After 10- or 90-min TPA treatment, AIF4(-)--but not Ca2+ ionophore-induced PI hydrolysis was inhibited, whereas [3H]BK binding was unaffected, indicating that the site of action of PKC-alpha and PKC-delta in the BK receptor/G protein/PLC pathway is after the receptor and before PLC, i.e., the G protein.	Tetradecanoylphorbol Acetate	20-23	protein kinase C alpha	Homo sapiens	181-190
7623773-14	1995	The increase in AIF4(-)-induced PI hydrolysis after 24-hr TPA treatment was also inhibited by cycloheximide, indicating that new synthesis of BK receptors and G proteins was required after down-regulation of PKC-alpha and PKC-delta.	Tetradecanoylphorbol Acetate	58-61	itchy E3 ubiquitin protein ligase	Homo sapiens	16-20
7623773-14	1995	The increase in AIF4(-)-induced PI hydrolysis after 24-hr TPA treatment was also inhibited by cycloheximide, indicating that new synthesis of BK receptors and G proteins was required after down-regulation of PKC-alpha and PKC-delta.	Tetradecanoylphorbol Acetate	58-61	protein kinase C alpha	Homo sapiens	208-217
7637391-2	1995	We demonstrated by 32P-labeling that the short (1 h) treatment of the REH6 cells with the tumor promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), resulted in a rapid phosphorylation of at least three (P1, P2 and P3) stathmin isoforms without an alteration of stathmin isoform expression.	Tetradecanoylphorbol Acetate	121-157	stathmin 1	Mus musculus	235-243
7637391-2	1995	We demonstrated by 32P-labeling that the short (1 h) treatment of the REH6 cells with the tumor promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), resulted in a rapid phosphorylation of at least three (P1, P2 and P3) stathmin isoforms without an alteration of stathmin isoform expression.	Tetradecanoylphorbol Acetate	121-157	stathmin 1	Mus musculus	278-286
7637391-2	1995	We demonstrated by 32P-labeling that the short (1 h) treatment of the REH6 cells with the tumor promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), resulted in a rapid phosphorylation of at least three (P1, P2 and P3) stathmin isoforms without an alteration of stathmin isoform expression.	Tetradecanoylphorbol Acetate	159-162	stathmin 1	Mus musculus	235-243
7637391-2	1995	We demonstrated by 32P-labeling that the short (1 h) treatment of the REH6 cells with the tumor promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), resulted in a rapid phosphorylation of at least three (P1, P2 and P3) stathmin isoforms without an alteration of stathmin isoform expression.	Tetradecanoylphorbol Acetate	159-162	stathmin 1	Mus musculus	278-286
7637391-3	1995	Furthermore, Western blot analysis with specific antiserum showed that the prolonged period (48 h) of TPA treatment partially reduced protein levels particularly of two (N2 and P2) stathmin isoforms.	Tetradecanoylphorbol Acetate	102-105	stathmin 1	Mus musculus	181-189
7769675-10	1995	TPA treatment of Raji cells caused a temporal loss of YY1-binding activity but had no effect on the intracellular levels of YY1 protein.	Tetradecanoylphorbol Acetate	0-3	YY1 transcription factor	Homo sapiens	54-57
7791759-7	1995	Upon stimulation of RelA-overexpressing thymocytes with phorbol 12-myristate 13-acetate and lectin (phytohemaglutinin), different kappa B-binding complexes, including RelA homodimers, were partially released from I kappa B alpha.	Tetradecanoylphorbol Acetate	56-87	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	213-228
7554227-9	1995	These studies revealed that 20 min treatment with TPA leads to a 3-fold increase in the rate of newly synthesized full-length vimentin assembly (posttranslational assembly).	Tetradecanoylphorbol Acetate	50-53	vimentin	Gallus gallus	126-134
7554227-10	1995	Furthermore, TPA increased cotranslational assembly of vimentin.	Tetradecanoylphorbol Acetate	13-16	vimentin	Gallus gallus	55-63
7775645-6	1995	PMNLs exposed to IGF-I increased their f-met-leu-phe and phorbol myristate acetate-induced oxidative burst, as evaluated by hydrogen peroxide production, whereas IGF-I did not influence PMNL actin polymerization.	Tetradecanoylphorbol Acetate	57-82	insulin like growth factor 1	Homo sapiens	17-22
7554585-4	1995	The known PKC stimulator, phorbol ester 12-0-tetradecanoylphorbol 13-acetate (TPA), caused maximal translocation of PKC at 100 nM with a 84.5% decrease in cytosolic PKC and a corresponding 252.1% increase in membrane-bound PKC.	Tetradecanoylphorbol Acetate	78-81	proline rich transmembrane protein 2	Homo sapiens	10-13
7554585-4	1995	The known PKC stimulator, phorbol ester 12-0-tetradecanoylphorbol 13-acetate (TPA), caused maximal translocation of PKC at 100 nM with a 84.5% decrease in cytosolic PKC and a corresponding 252.1% increase in membrane-bound PKC.	Tetradecanoylphorbol Acetate	78-81	proline rich transmembrane protein 2	Homo sapiens	116-119
7554585-4	1995	The known PKC stimulator, phorbol ester 12-0-tetradecanoylphorbol 13-acetate (TPA), caused maximal translocation of PKC at 100 nM with a 84.5% decrease in cytosolic PKC and a corresponding 252.1% increase in membrane-bound PKC.	Tetradecanoylphorbol Acetate	78-81	proline rich transmembrane protein 2	Homo sapiens	116-119
7554585-4	1995	The known PKC stimulator, phorbol ester 12-0-tetradecanoylphorbol 13-acetate (TPA), caused maximal translocation of PKC at 100 nM with a 84.5% decrease in cytosolic PKC and a corresponding 252.1% increase in membrane-bound PKC.	Tetradecanoylphorbol Acetate	78-81	proline rich transmembrane protein 2	Homo sapiens	116-119
7768563-6	1995	The protein kinase C (PKC)-activating phorbol ester phorbol myristate acetate stimulated ET-1 production in a concentration-dependent manner in cells of both rat strains, but this stimulation was significantly greater in SHR than WKY cells.	Tetradecanoylphorbol Acetate	52-77	endothelin 1	Rattus norvegicus	89-93
7760005-12	1995	FMLP-induced release of the IL-1 decoy RII was unaffected by protein synthesis inhibitors, was blocked by certain protease inhibitors, and was mimicked by agents (the Ca++ ionophore A23187 and phorbol myristate acetate) that recapitulate elements in the signal transduction pathway of chemoattractant receptors.	Tetradecanoylphorbol Acetate	193-218	formyl peptide receptor 1	Homo sapiens	0-4
7598740-9	1995	The PKC activator phorbol 12-myristate 13-acetate (0.4 microM) stimulated ET-1 release 1.4-fold (P &lt; 0.01) and its effect was abolished by EGTA (5 mM).	Tetradecanoylphorbol Acetate	18-49	endothelin 1	Homo sapiens	74-78
7759889-6	1995	More than 35% of the cell-associated IL-8 could be released by stimulation with either Ca2+ ionophore A23187 or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	112-137	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
7779100-2	1995	The activation of membrane-bound PLD by PKC partially purified from rat brain was most effectively induced with phorbol 12-myristate 13-acetate (PMA) and Ca2+ (1 microM) which caused translocation of PKC to membranes.	Tetradecanoylphorbol Acetate	112-143	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	33-36
7779100-2	1995	The activation of membrane-bound PLD by PKC partially purified from rat brain was most effectively induced with phorbol 12-myristate 13-acetate (PMA) and Ca2+ (1 microM) which caused translocation of PKC to membranes.	Tetradecanoylphorbol Acetate	145-148	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	33-36
7772059-4	1995	The increased labelling of alpha-Gi-2 seen after challenge of cells with phorbol 12-myristate 13-acetate was also attenuated by insulin.	Tetradecanoylphorbol Acetate	73-104	insulin	Homo sapiens	128-135
7669730-8	1995	Forskolin induces the expression of both MUC2 and MUC3, whereas 12-O-tetradecanoylphorbol-13-acetate is capable of inducing only MUC2, and sodium butyrate, only MUC3 gene expression.	Tetradecanoylphorbol Acetate	64-100	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	129-133
7669730-8	1995	Forskolin induces the expression of both MUC2 and MUC3, whereas 12-O-tetradecanoylphorbol-13-acetate is capable of inducing only MUC2, and sodium butyrate, only MUC3 gene expression.	Tetradecanoylphorbol Acetate	64-100	MUC3	Homo sapiens	161-165
7769268-9	1995	Using electrophoretic mobility shift assays, a PMA-inducible binding site was identified for an NF kappa B-like complex within positions -186/-177.	Tetradecanoylphorbol Acetate	47-50	nuclear factor kappa B subunit 1	Homo sapiens	96-106
7553227-4	1995	As expected, IL-10 suppressed PMA-induced TNF-alpha production in U1 cells; however, when U1 cells were cultured in the presence of PMA and increasing doses of IL-10, a dose-dependent increase in HIV-1 expression was observed.	Tetradecanoylphorbol Acetate	30-33	tumor necrosis factor	Homo sapiens	42-51
7626451-9	1995	These results indicate that NF-IL6 is one of the nuclear factors which participate in TPA-mediated transcriptional enhancement of CYP 19 gene expression.	Tetradecanoylphorbol Acetate	86-89	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	130-136
7791343-10	1995	Pretreatment with PMA partially reproduced LPSp pretreatment.	Tetradecanoylphorbol Acetate	18-21	toll-like receptor 4	Mus musculus	43-47
7643856-2	1995	An activator of protein kinase C (PKC), 12-O-tetradecanoyl-1,2-phorbol 13-acetate (TPA), was found to enhance expression of Ii mRNA in the murine B lymphoma cell line, A20, 6-48 hr following treatment.	Tetradecanoylphorbol Acetate	83-86	protein kinase C, alpha	Mus musculus	34-37
7643856-4	1995	TPA addition to either cell line activated PKC.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Mus musculus	43-46
7643856-5	1995	Pretreatment of A20 cells with the PKC inhibitors, staurosporine or chelerythrine chloride, for 5 or 20 min prior to addition of TPA, decreased Ii mRNA levels when compared to cells treated with TPA alone.	Tetradecanoylphorbol Acetate	129-132	protein kinase C, alpha	Mus musculus	35-38
7643856-5	1995	Pretreatment of A20 cells with the PKC inhibitors, staurosporine or chelerythrine chloride, for 5 or 20 min prior to addition of TPA, decreased Ii mRNA levels when compared to cells treated with TPA alone.	Tetradecanoylphorbol Acetate	195-198	protein kinase C, alpha	Mus musculus	35-38
7643856-6	1995	A 20 min preincubation with the highly specific PKC inhibitor, calphostin C, completely blocked the TPA enhanced expression of the Ii suggesting that activation of PKC was responsible for TPA increased Ii mRNA levels.	Tetradecanoylphorbol Acetate	100-103	protein kinase C, alpha	Mus musculus	48-51
7643856-6	1995	A 20 min preincubation with the highly specific PKC inhibitor, calphostin C, completely blocked the TPA enhanced expression of the Ii suggesting that activation of PKC was responsible for TPA increased Ii mRNA levels.	Tetradecanoylphorbol Acetate	100-103	protein kinase C, alpha	Mus musculus	164-167
7643856-6	1995	A 20 min preincubation with the highly specific PKC inhibitor, calphostin C, completely blocked the TPA enhanced expression of the Ii suggesting that activation of PKC was responsible for TPA increased Ii mRNA levels.	Tetradecanoylphorbol Acetate	188-191	protein kinase C, alpha	Mus musculus	48-51
7643856-6	1995	A 20 min preincubation with the highly specific PKC inhibitor, calphostin C, completely blocked the TPA enhanced expression of the Ii suggesting that activation of PKC was responsible for TPA increased Ii mRNA levels.	Tetradecanoylphorbol Acetate	188-191	protein kinase C, alpha	Mus musculus	164-167
7643856-7	1995	IFN-gamma also blocked the TPA increased Ii mRNA levels.	Tetradecanoylphorbol Acetate	27-30	interferon gamma	Mus musculus	0-9
7760824-1	1995	Human myeloid leukemia cells, such as HL60, U937, and THP1 cells, undergo macrophage differentiation and growth arrest following treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	162-198	GLI family zinc finger 2	Homo sapiens	54-58
7760824-1	1995	Human myeloid leukemia cells, such as HL60, U937, and THP1 cells, undergo macrophage differentiation and growth arrest following treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	200-203	GLI family zinc finger 2	Homo sapiens	54-58
7760824-7	1995	Analysis of THP1 nuclear proteins revealed a 55-kDa protein that was induced by TPA and interacted with the cdc2 promoter in an R-box-dependent manner.	Tetradecanoylphorbol Acetate	80-83	GLI family zinc finger 2	Homo sapiens	12-16
7744820-8	1995	These results suggest that Tax triggers I kappa B-alpha degradation and thus NF-kappa B activation by a mechanism that converges with that induced by extracellular stimulation such as phorbol 12-myristate 13-acetate/ionomycin or tumor necrosis factor alpha.	Tetradecanoylphorbol Acetate	184-215	NFKB inhibitor alpha	Homo sapiens	40-55
7644142-3	1995	Here we demonstrate that the reporter gene expression can be further induced by the action of phorbol 12-myristate 13-acetate (TPA) and nerve growth factor (NGF), respectively, in both HeLa and the neuronally derived PC12 cells.	Tetradecanoylphorbol Acetate	94-125	plasminogen activator, tissue type	Homo sapiens	127-130
7744820-8	1995	These results suggest that Tax triggers I kappa B-alpha degradation and thus NF-kappa B activation by a mechanism that converges with that induced by extracellular stimulation such as phorbol 12-myristate 13-acetate/ionomycin or tumor necrosis factor alpha.	Tetradecanoylphorbol Acetate	184-215	nuclear factor kappa B subunit 1	Homo sapiens	77-87
7601107-2	1995	Previously, we found that the differentiation of K562 cells induced by 4 beta-phorbol 12-myristate 13-acetate treatment is accompanied by an increase in m-calpain levels and, at the same time, m-calpain becomes localized on the inside of plasma membranes, coated pits, and coated vesicles [Nakamura, M., Mori, M., Morishita, Y., Mori, S. &amp; Kawashima, S. (1992) Exp.	Tetradecanoylphorbol Acetate	73-109	calpain 2	Homo sapiens	153-162
7737978-6	1995	TPA treatment also results in a time-dependent decrease in 125I-MGSA binding to the 3ASubE P-3 cells.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 10 member 3	Homo sapiens	91-94
7766667-7	1995	Short-term exposure of the cells to 12-O-tetradecanoylphorbol 13-acetate (TPA) completely suppressed the sulprostone-induced increase in intracellular Ca2+ concentration, while forskolin or dibutyryl cAMP did not affect it, suggesting that protein kinase C but not protein kinase A is involved in the regulation of the EP1 signal transduction.	Tetradecanoylphorbol Acetate	36-72	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	319-322
7766667-7	1995	Short-term exposure of the cells to 12-O-tetradecanoylphorbol 13-acetate (TPA) completely suppressed the sulprostone-induced increase in intracellular Ca2+ concentration, while forskolin or dibutyryl cAMP did not affect it, suggesting that protein kinase C but not protein kinase A is involved in the regulation of the EP1 signal transduction.	Tetradecanoylphorbol Acetate	74-77	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	319-322
7766667-8	1995	Furthermore, long-term exposure to TPA decreased PGE2 protein kinase A is involved in the regulation of the EP1 signal transduction.	Tetradecanoylphorbol Acetate	35-38	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	108-111
7766667-9	1995	Furthermore, long-term exposure to TPA decreased PGE2 binding activity of EP1 due to the reduction of the EP1 mRNA level.	Tetradecanoylphorbol Acetate	35-38	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	74-77
7766667-9	1995	Furthermore, long-term exposure to TPA decreased PGE2 binding activity of EP1 due to the reduction of the EP1 mRNA level.	Tetradecanoylphorbol Acetate	35-38	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	106-109
7762668-1	1995	The T lymphocyte product interferon-gamma (IFN-gamma) upregulates or primes polymorphonuclear leukocyte (PMN) oxidative responses to the receptor-initiated stimulant N-formyl-methionyl-leucyl-phenylalanine (FMLP) but not to the transduction-mediated stimulant phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	260-285	interferon gamma	Oryctolagus cuniculus	25-41
7747803-4	1995	Immunohistochemical staining and flow cytometry analysis revealed that normal cultured keratinocytes express low levels of Fas, CD40, and Bcl-x that was enhanced by cytokines including gamma-interferon (IFN-gamma) and a phorbol ester tumor promoter, TPA.	Tetradecanoylphorbol Acetate	250-253	BCL2 like 1	Homo sapiens	138-143
7747803-4	1995	Immunohistochemical staining and flow cytometry analysis revealed that normal cultured keratinocytes express low levels of Fas, CD40, and Bcl-x that was enhanced by cytokines including gamma-interferon (IFN-gamma) and a phorbol ester tumor promoter, TPA.	Tetradecanoylphorbol Acetate	250-253	interferon gamma	Homo sapiens	203-212
7747803-5	1995	Only faint Bcl-2 staining was detected in cultured keratinocytes exposed to IFN-gamma and TPA compared with the prominent expression of Bcl-x.	Tetradecanoylphorbol Acetate	90-93	BCL2 apoptosis regulator	Homo sapiens	11-16
7762668-1	1995	The T lymphocyte product interferon-gamma (IFN-gamma) upregulates or primes polymorphonuclear leukocyte (PMN) oxidative responses to the receptor-initiated stimulant N-formyl-methionyl-leucyl-phenylalanine (FMLP) but not to the transduction-mediated stimulant phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	260-285	interferon gamma	Oryctolagus cuniculus	43-52
7762668-1	1995	The T lymphocyte product interferon-gamma (IFN-gamma) upregulates or primes polymorphonuclear leukocyte (PMN) oxidative responses to the receptor-initiated stimulant N-formyl-methionyl-leucyl-phenylalanine (FMLP) but not to the transduction-mediated stimulant phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	287-290	interferon gamma	Oryctolagus cuniculus	25-41
7762668-1	1995	The T lymphocyte product interferon-gamma (IFN-gamma) upregulates or primes polymorphonuclear leukocyte (PMN) oxidative responses to the receptor-initiated stimulant N-formyl-methionyl-leucyl-phenylalanine (FMLP) but not to the transduction-mediated stimulant phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	287-290	interferon gamma	Oryctolagus cuniculus	43-52
8527309-5	1995	In the 17 beta-oestradiol-treated cells, TPA-stimulated PLD activity was significantly elevated at 100 nM TPA (P &lt; 0.05) and 1 microM TPA (P &lt; 0.05) compared to responses in the untreated cells, suggesting that 17 beta-oestradiol may upregulate PKC activity.	Tetradecanoylphorbol Acetate	106-109	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	56-59
7668385-3	1995	This technique was successfully applied to evaluate differences in glucocorticoid receptor expression in U937 cells before and after the addition of potent differentiation inducers: 12-O-tetradecanoylphorbol 13-acetate (TPA) and a combination of all-trans retinoic acid (RA) and 1,25-dihydroxyvitamin D2 (VD).	Tetradecanoylphorbol Acetate	182-218	nuclear receptor subfamily 3 group C member 1	Homo sapiens	67-90
7626723-4	1995	At 4 and 8 h, TPA increased the accumulation of P450scc mRNA, having an additive effect with FSH.	Tetradecanoylphorbol Acetate	14-17	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	48-55
7626723-5	1995	However, at 24 h, TPA markedly suppressed the FSH-induced increased in P450scc mRNA.	Tetradecanoylphorbol Acetate	18-21	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	71-78
7626723-7	1995	The stimulatory effect of 8-bromo-cAMP on P450scc mRNA also was augmented by TPA at 4 h, but significant inhibition was not observed at 24 h. The concentration of glyceraldehyde-3-phosphate dehydrogenase mRNA, intended to be used for correction of gel loading, was stably increased by both cAMP and TPA.	Tetradecanoylphorbol Acetate	77-80	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	42-49
7626723-7	1995	The stimulatory effect of 8-bromo-cAMP on P450scc mRNA also was augmented by TPA at 4 h, but significant inhibition was not observed at 24 h. The concentration of glyceraldehyde-3-phosphate dehydrogenase mRNA, intended to be used for correction of gel loading, was stably increased by both cAMP and TPA.	Tetradecanoylphorbol Acetate	77-80	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	163-203
7626723-7	1995	The stimulatory effect of 8-bromo-cAMP on P450scc mRNA also was augmented by TPA at 4 h, but significant inhibition was not observed at 24 h. The concentration of glyceraldehyde-3-phosphate dehydrogenase mRNA, intended to be used for correction of gel loading, was stably increased by both cAMP and TPA.	Tetradecanoylphorbol Acetate	299-302	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	42-49
7626723-7	1995	The stimulatory effect of 8-bromo-cAMP on P450scc mRNA also was augmented by TPA at 4 h, but significant inhibition was not observed at 24 h. The concentration of glyceraldehyde-3-phosphate dehydrogenase mRNA, intended to be used for correction of gel loading, was stably increased by both cAMP and TPA.	Tetradecanoylphorbol Acetate	299-302	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	163-203
7626723-8	1995	These effects of TPA suggest multiple actions of PKC(s) on the regulation of P450scc expression and other endpoints in ovarian granulosa cells.	Tetradecanoylphorbol Acetate	17-20	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	77-84
8527309-2	1995	The effect of 17 beta-oestradiol on PAF- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-evoked PLD activity assayed as an accumulation of [3H]phosphatidylbutanol was examined in [3H]myristic acid labelled in a human endometrial epithelial cell line HEC-1B.	Tetradecanoylphorbol Acetate	45-81	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	95-98
8527309-2	1995	The effect of 17 beta-oestradiol on PAF- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-evoked PLD activity assayed as an accumulation of [3H]phosphatidylbutanol was examined in [3H]myristic acid labelled in a human endometrial epithelial cell line HEC-1B.	Tetradecanoylphorbol Acetate	83-86	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	95-98
8527309-3	1995	TPA stimulated PLD activity in a dose-dependent manner whereas PAF had no significant effect on PLD activity.	Tetradecanoylphorbol Acetate	0-3	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	15-18
8527309-5	1995	In the 17 beta-oestradiol-treated cells, TPA-stimulated PLD activity was significantly elevated at 100 nM TPA (P &lt; 0.05) and 1 microM TPA (P &lt; 0.05) compared to responses in the untreated cells, suggesting that 17 beta-oestradiol may upregulate PKC activity.	Tetradecanoylphorbol Acetate	41-44	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	56-59
7727777-7	1995	We show here that TGF-beta treatment of phorbol myristate acetate (PMA) or anti-Ig-activated RL cells results in growth inhibition through a dual effect on Rb and mutant p53.	Tetradecanoylphorbol Acetate	40-65	transforming growth factor beta 1	Homo sapiens	18-26
7727777-7	1995	We show here that TGF-beta treatment of phorbol myristate acetate (PMA) or anti-Ig-activated RL cells results in growth inhibition through a dual effect on Rb and mutant p53.	Tetradecanoylphorbol Acetate	40-65	tumor protein p53	Homo sapiens	170-173
7727777-7	1995	We show here that TGF-beta treatment of phorbol myristate acetate (PMA) or anti-Ig-activated RL cells results in growth inhibition through a dual effect on Rb and mutant p53.	Tetradecanoylphorbol Acetate	67-70	transforming growth factor beta 1	Homo sapiens	18-26
7727777-7	1995	We show here that TGF-beta treatment of phorbol myristate acetate (PMA) or anti-Ig-activated RL cells results in growth inhibition through a dual effect on Rb and mutant p53.	Tetradecanoylphorbol Acetate	67-70	tumor protein p53	Homo sapiens	170-173
7750207-3	1995	The effects of amiloride on the modulation of uPA mRNA and protein induced by phorbol ester (PMA) and cycloheximide (CHX) were studied in four colon cancer cell lines, HCT116, KM12SM, LIM1215 and LS123.	Tetradecanoylphorbol Acetate	93-96	plasminogen activator, urokinase	Homo sapiens	46-49
7750207-8	1995	uPA protein levels on the colon cancer cell surface reflected PMA induction and amiloride inhibition of uPA mRNA levels.	Tetradecanoylphorbol Acetate	62-65	plasminogen activator, urokinase	Homo sapiens	0-3
7656184-7	1995	The phorbol ester TPA--an activator of protein kinase C--and to a lesser extent FGF but not EGF, stimulated osteopontin gene expression.	Tetradecanoylphorbol Acetate	18-21	secreted phosphoprotein 1	Gallus gallus	108-119
8527309-5	1995	In the 17 beta-oestradiol-treated cells, TPA-stimulated PLD activity was significantly elevated at 100 nM TPA (P &lt; 0.05) and 1 microM TPA (P &lt; 0.05) compared to responses in the untreated cells, suggesting that 17 beta-oestradiol may upregulate PKC activity.	Tetradecanoylphorbol Acetate	106-109	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	56-59
8527309-7	1995	TPA (10 nM) and PAF (100 nM) stimulated PLD activity.	Tetradecanoylphorbol Acetate	0-3	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	40-43
8527309-8	1995	However, TPA-stimulated PLD activity levels fell 10-fold while PAF-mediated PLD activity remained elevated at 10 nM and 100 nM concentrations of 17 beta-oestradiol suggesting a different mechanism of activation.	Tetradecanoylphorbol Acetate	9-12	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	24-27
7648800-2	1995	Lucigenin-enhanced chemiluminescence (CL) to phorbol myristate acetate as respiratory burst and sorbitol levels in neutrophils after incubation with glucose and an aldose reductase (AR) inhibitor, SNK-860 (SNK) were measured.	Tetradecanoylphorbol Acetate	45-70	aldo-keto reductase family 1 member B	Homo sapiens	164-180
7648800-2	1995	Lucigenin-enhanced chemiluminescence (CL) to phorbol myristate acetate as respiratory burst and sorbitol levels in neutrophils after incubation with glucose and an aldose reductase (AR) inhibitor, SNK-860 (SNK) were measured.	Tetradecanoylphorbol Acetate	45-70	aldo-keto reductase family 1 member B	Homo sapiens	182-184
7672438-1	1995	Androgen (R1881) induced transcriptional activity of the human androgen receptor, stably expressed in CHO cells, can be stimulated an extra 2-fold by the addition of the protein kinase C activator, 4 beta-phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	198-236	androgen receptor	Homo sapiens	63-80
7720675-2	1995	The purpose of the present study was to characterize the effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on the secretion, biosynthesis, and steady-state messenger RNA (mRNA) levels of chromogranin A (CGA) and of a coresident peptide, neurotensin, by a novel human pancreatic carcinoid cell line, called BON.	Tetradecanoylphorbol Acetate	68-105	chromogranin A	Homo sapiens	192-206
7720675-2	1995	The purpose of the present study was to characterize the effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on the secretion, biosynthesis, and steady-state messenger RNA (mRNA) levels of chromogranin A (CGA) and of a coresident peptide, neurotensin, by a novel human pancreatic carcinoid cell line, called BON.	Tetradecanoylphorbol Acetate	68-105	chromogranin A	Homo sapiens	208-211
7720675-2	1995	The purpose of the present study was to characterize the effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on the secretion, biosynthesis, and steady-state messenger RNA (mRNA) levels of chromogranin A (CGA) and of a coresident peptide, neurotensin, by a novel human pancreatic carcinoid cell line, called BON.	Tetradecanoylphorbol Acetate	107-110	chromogranin A	Homo sapiens	192-206
7720675-2	1995	The purpose of the present study was to characterize the effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on the secretion, biosynthesis, and steady-state messenger RNA (mRNA) levels of chromogranin A (CGA) and of a coresident peptide, neurotensin, by a novel human pancreatic carcinoid cell line, called BON.	Tetradecanoylphorbol Acetate	107-110	chromogranin A	Homo sapiens	208-211
7720675-2	1995	The purpose of the present study was to characterize the effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on the secretion, biosynthesis, and steady-state messenger RNA (mRNA) levels of chromogranin A (CGA) and of a coresident peptide, neurotensin, by a novel human pancreatic carcinoid cell line, called BON.	Tetradecanoylphorbol Acetate	107-110	neurotensin	Homo sapiens	242-253
7720675-3	1995	Acute TPA treatment (100 nM, 1 h) of BON cells resulted in 20- and 40-fold elevations in release of CGA-IR and NT-IR, respectively; and a 70-90% depletion of CGA-IR and NT-IR cell contents.	Tetradecanoylphorbol Acetate	6-9	chromogranin A	Homo sapiens	100-103
7720675-3	1995	Acute TPA treatment (100 nM, 1 h) of BON cells resulted in 20- and 40-fold elevations in release of CGA-IR and NT-IR, respectively; and a 70-90% depletion of CGA-IR and NT-IR cell contents.	Tetradecanoylphorbol Acetate	6-9	chromogranin A	Homo sapiens	158-161
7720675-4	1995	TPA treatment also increased the biosynthetic rate of CGA-IR.	Tetradecanoylphorbol Acetate	0-3	chromogranin A	Homo sapiens	54-57
7774640-4	1995	After incubation with EPO, the macrophages produced large amounts of TNF and displayed an enhanced phorbol 12-myristate 13-acetate-triggered hydrogen peroxide release.	Tetradecanoylphorbol Acetate	99-130	eosinophil peroxidase	Homo sapiens	22-25
7613170-5	1995	IFN-gamma was produced following all three stimuli, but was greatest from cells cultured with PMA and ionomycin.	Tetradecanoylphorbol Acetate	94-97	interferon gamma	Homo sapiens	0-9
7613170-6	1995	However, IL-4 secretion was only detected in cell cultures stimulated with PMA and ionomycin.	Tetradecanoylphorbol Acetate	75-78	interleukin 4	Homo sapiens	9-13
7722482-2	1995	The blockade of protein kinase C catalytic domain, by staurosporine, as well as the desensitization of protein kinase C by short-term phorbol 12-myristate 13-acetate pretreatment, increased the basal release of interleukin 6 by rat cortical astrocytes, whereas calphostin C, an antagonist of phorbol ester binding on protein kinase C regulatory domain, did not affect the basal release of the cytokine.	Tetradecanoylphorbol Acetate	134-165	interleukin 6	Rattus norvegicus	211-224
7722482-3	1995	The activation of protein kinase C by phorbol 12-myristate 13-acetate enhanced concentration- and time-dependently interleukin 6 release.	Tetradecanoylphorbol Acetate	38-69	interleukin 6	Rattus norvegicus	115-128
7722482-4	1995	This stimulatory action of phorbol 12-myristate 13-acetate was significantly reduced by staurosporine, by calphostin C and by the desensitization of protein kinase C. Interleukin 1 beta increased interleukin 6 release in a concentration-related manner.	Tetradecanoylphorbol Acetate	27-58	interleukin 1 beta	Rattus norvegicus	167-185
7722482-4	1995	This stimulatory action of phorbol 12-myristate 13-acetate was significantly reduced by staurosporine, by calphostin C and by the desensitization of protein kinase C. Interleukin 1 beta increased interleukin 6 release in a concentration-related manner.	Tetradecanoylphorbol Acetate	27-58	interleukin 6	Rattus norvegicus	196-209
7722482-6	1995	The treatment of cortical astrocytes with both interleukin 1 beta (3 ng/ml) and phorbol 12-myristate 13-acetate (10 nM) caused a synergistic stimulation of interleukin 6 release and its gene expression, an effect that was not relieved by either 20 nM staurospine or by calphostin C but was slightly affected by protein kinase C desensitization.	Tetradecanoylphorbol Acetate	80-111	interleukin 6	Rattus norvegicus	156-169
7545622-1	1995	Aromatase cytochrome P450 mRNA and activity was strongly expressed in THP 1 myeloid leukaemia cells after treatment with phorbol-myristate-acetate (PMA) and dexamethasone, low level expression was caused by calcitriol.	Tetradecanoylphorbol Acetate	121-146	GLI family zinc finger 2	Homo sapiens	70-75
7545622-1	1995	Aromatase cytochrome P450 mRNA and activity was strongly expressed in THP 1 myeloid leukaemia cells after treatment with phorbol-myristate-acetate (PMA) and dexamethasone, low level expression was caused by calcitriol.	Tetradecanoylphorbol Acetate	148-151	GLI family zinc finger 2	Homo sapiens	70-75
7730342-9	1995	FGF-2, platelet-derived growth factor-BB, calf serum, or phorbol myristate acetate treatment of quiescent cells also induces fnk gene expression.	Tetradecanoylphorbol Acetate	57-82	polo like kinase 3	Mus musculus	125-128
7539752-5	1995	Lower IL-2 expression (detected only as mRNA synthesis) was also induced in the cultured B lymphocytes after incubation with cross-linking anti-IgM antibodies instead of PMA plus ionomycin.	Tetradecanoylphorbol Acetate	170-173	interleukin 2	Homo sapiens	6-10
7543447-0	1995	Regulation of CD59 expression on K562 cells: effects of phorbol myristate acetate, cross-linking antibody and non-lethal complement attack.	Tetradecanoylphorbol Acetate	56-81	CD59 molecule (CD59 blood group)	Homo sapiens	14-18
7543447-3	1995	We have chosen the K562 erythroleukaemia cell line as a model for studies of the regulation of CD59 expression, because it has previously been reported that phorbol 12-myristate 13-acetate (PMA) caused a 15-fold up-regulation of CD59 mRNA in these cells, implying a substantial capacity for CD59 synthesis.	Tetradecanoylphorbol Acetate	157-188	CD59 molecule (CD59 blood group)	Homo sapiens	95-99
7543447-3	1995	We have chosen the K562 erythroleukaemia cell line as a model for studies of the regulation of CD59 expression, because it has previously been reported that phorbol 12-myristate 13-acetate (PMA) caused a 15-fold up-regulation of CD59 mRNA in these cells, implying a substantial capacity for CD59 synthesis.	Tetradecanoylphorbol Acetate	157-188	CD59 molecule (CD59 blood group)	Homo sapiens	229-233
7543447-3	1995	We have chosen the K562 erythroleukaemia cell line as a model for studies of the regulation of CD59 expression, because it has previously been reported that phorbol 12-myristate 13-acetate (PMA) caused a 15-fold up-regulation of CD59 mRNA in these cells, implying a substantial capacity for CD59 synthesis.	Tetradecanoylphorbol Acetate	157-188	CD59 molecule (CD59 blood group)	Homo sapiens	229-233
7543447-3	1995	We have chosen the K562 erythroleukaemia cell line as a model for studies of the regulation of CD59 expression, because it has previously been reported that phorbol 12-myristate 13-acetate (PMA) caused a 15-fold up-regulation of CD59 mRNA in these cells, implying a substantial capacity for CD59 synthesis.	Tetradecanoylphorbol Acetate	190-193	CD59 molecule (CD59 blood group)	Homo sapiens	95-99
7543447-3	1995	We have chosen the K562 erythroleukaemia cell line as a model for studies of the regulation of CD59 expression, because it has previously been reported that phorbol 12-myristate 13-acetate (PMA) caused a 15-fold up-regulation of CD59 mRNA in these cells, implying a substantial capacity for CD59 synthesis.	Tetradecanoylphorbol Acetate	190-193	CD59 molecule (CD59 blood group)	Homo sapiens	229-233
7543447-3	1995	We have chosen the K562 erythroleukaemia cell line as a model for studies of the regulation of CD59 expression, because it has previously been reported that phorbol 12-myristate 13-acetate (PMA) caused a 15-fold up-regulation of CD59 mRNA in these cells, implying a substantial capacity for CD59 synthesis.	Tetradecanoylphorbol Acetate	190-193	CD59 molecule (CD59 blood group)	Homo sapiens	229-233
7473001-4	1995	Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts.	Tetradecanoylphorbol Acetate	71-102	tumor necrosis factor	Homo sapiens	191-200
7473001-4	1995	Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts.	Tetradecanoylphorbol Acetate	71-102	interleukin 1 beta	Homo sapiens	209-218
7473001-4	1995	Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts.	Tetradecanoylphorbol Acetate	104-107	kininogen 1	Homo sapiens	11-13
7473001-4	1995	Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts.	Tetradecanoylphorbol Acetate	104-107	tumor necrosis factor	Homo sapiens	191-200
7473001-4	1995	Similar to BK, two phorbol esters, phorbol 12,13 dibutyrate (PDBu) and phorbol 12-myristate-13-acetate (PMA) which are known to stimulate protein kinase C (PKC), synergistically enhanced the TNF alpha induced IL-1 beta production in the gingival fibroblasts.	Tetradecanoylphorbol Acetate	104-107	interleukin 1 beta	Homo sapiens	209-218
7492943-6	1995	Treatment of both cells with TPA for 10 min resulted in the translocation of PKC alpha, PKC delta and PKC epsilon to the membrane fraction.	Tetradecanoylphorbol Acetate	29-32	protein kinase C, alpha	Mus musculus	77-86
7672438-1	1995	Androgen (R1881) induced transcriptional activity of the human androgen receptor, stably expressed in CHO cells, can be stimulated an extra 2-fold by the addition of the protein kinase C activator, 4 beta-phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	238-241	androgen receptor	Homo sapiens	63-80
7730383-5	1995	Activation of each isozyme"s kinase activity (with the exception of PKC-zeta) by treatment of these cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate results in isozyme-specific alterations of cell morphology, as well as in a rapid, selective redistribution of the different PKC isozymes to distinct subcellular structures.	Tetradecanoylphorbol Acetate	129-165	protein kinase C alpha	Homo sapiens	68-71
7730383-6	1995	Within minutes after 12-O-tetradecanoylphorbol-13-acetate treatment, PKC-alpha and -epsilon concentrate at cell margins.	Tetradecanoylphorbol Acetate	21-57	protein kinase C alpha	Homo sapiens	69-78
7733897-5	1995	Down-regulation of protein kinase C by a 24 h incubation of cells with phorbol myristate acetate prevented the effects of HDL3 on the phosphorylation of 24 and 28 kDa proteins.	Tetradecanoylphorbol Acetate	71-96	HDL3	Homo sapiens	122-126
7620889-5	1995	Incubation of the cells with PMA (10(-7) M), a protein kinase C (PKC) agonist, had no effect on basal cAMP, but potentiated CRH-stimulated cAMP.	Tetradecanoylphorbol Acetate	29-32	corticotropin releasing hormone	Rattus norvegicus	124-127
7620889-5	1995	Incubation of the cells with PMA (10(-7) M), a protein kinase C (PKC) agonist, had no effect on basal cAMP, but potentiated CRH-stimulated cAMP.	Tetradecanoylphorbol Acetate	29-32	cathelicidin antimicrobial peptide	Rattus norvegicus	139-143
7704900-2	1995	A rapid increase in pim-1 mRNA levels was found after stimulation of normal unseparated PBMCs with phorbol ester (PMA) and a calcium ionophore (ionomycin) with the peak level occurring 4 hr poststimulation.	Tetradecanoylphorbol Acetate	114-117	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	20-25
7704900-5	1995	This basal level of pim-1 expression could be increased by stimulation of alpha/beta-T cells (approx fivefold) and gamma/delta-T cells (approximately sevenfold) with PMA plus ionomycin.	Tetradecanoylphorbol Acetate	166-169	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	20-25
7733936-0	1995	The protein kinase C inhibitor, bisindolylmaleimide, inhibits the TPA-induced but not the TNF-induced increase in LLC-PK1 transepithelial permeability.	Tetradecanoylphorbol Acetate	66-69	PKC	Sus scrofa	4-20
7733936-1	1995	The transepithelial paracellular permeability of an epithelium formed by LLC-PK1 cells increases upon activation of protein kinase C (PKC) by the phorbol ester tumor promoter, TPA, or in response to the cytokine tumor necrosis factor-alpha (TNF).	Tetradecanoylphorbol Acetate	176-179	PKC	Sus scrofa	116-132
7733936-1	1995	The transepithelial paracellular permeability of an epithelium formed by LLC-PK1 cells increases upon activation of protein kinase C (PKC) by the phorbol ester tumor promoter, TPA, or in response to the cytokine tumor necrosis factor-alpha (TNF).	Tetradecanoylphorbol Acetate	176-179	PKC	Sus scrofa	134-137
7733936-3	1995	In this study we report the treatment of epithelial cell sheets with the selective PKC inhibitor bisindolylmaleimide, GF109203X, completely prevents the TPA-induced but not the TNF-alpha induced increase in tight junction permeability.	Tetradecanoylphorbol Acetate	153-156	PKC	Sus scrofa	83-86
7717978-5	1995	The tumour promoter and protein kinase C agonist, phorbol 12-myristate 13-acetate (PMA), also activated Raf-1, MEK-1, and MAP kinase in Ramos cells, but did not induce tyrosine phosphorylation of Shc or Shc/Grb2 association.	Tetradecanoylphorbol Acetate	50-81	growth factor receptor bound protein 2	Homo sapiens	207-211
7733936-4	1995	While PKC-alpha still translocates from the cytosol to the membrane of TPA-stimulated epithelial cells overall PKC activity in the membrane fraction is markedly reduced in the presence of GFX.	Tetradecanoylphorbol Acetate	71-74	PKC	Sus scrofa	6-9
7733936-4	1995	While PKC-alpha still translocates from the cytosol to the membrane of TPA-stimulated epithelial cells overall PKC activity in the membrane fraction is markedly reduced in the presence of GFX.	Tetradecanoylphorbol Acetate	71-74	PKC	Sus scrofa	111-114
7713904-1	1995	Calmodulin (CaM) antagonists chlorpromazine, trifluoperazine, and N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide HCl inhibit Jurkat T cell activation, as monitored by measuring interleukin-2 synthesis in cells treated by a combination of CD3 monoclonal antibody and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	271-296	calmodulin 1	Homo sapiens	0-10
7713904-1	1995	Calmodulin (CaM) antagonists chlorpromazine, trifluoperazine, and N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide HCl inhibit Jurkat T cell activation, as monitored by measuring interleukin-2 synthesis in cells treated by a combination of CD3 monoclonal antibody and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	271-296	calmodulin 1	Homo sapiens	12-15
7726865-2	1995	We used a luciferase reporter assay to identify sequences that regulate c-fgr gene transcription during differentiation of human U937 promonocytic cells, induced by phorbol 12-myristate 13-acetate (PMA) or by tumour necrosis factor-alpha (TNF-alpha) and 1,25-dihydroxycholecalciferol (1,25-DHCC).	Tetradecanoylphorbol Acetate	165-196	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-77
7726865-2	1995	We used a luciferase reporter assay to identify sequences that regulate c-fgr gene transcription during differentiation of human U937 promonocytic cells, induced by phorbol 12-myristate 13-acetate (PMA) or by tumour necrosis factor-alpha (TNF-alpha) and 1,25-dihydroxycholecalciferol (1,25-DHCC).	Tetradecanoylphorbol Acetate	198-201	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-77
7706710-10	1995	Conversely, calcium-independent anti-CD28 Ab and PMA-induced IL-2 production was resistant.	Tetradecanoylphorbol Acetate	49-52	interleukin 2	Homo sapiens	61-65
7713928-4	1995	Although addition of 12-O-tetradecanoylphorbol 13-acetate also resulted in phosphorylation of the GRP-R, elimination of protein kinase C activity using the inhibitor 7-hydroxystaurosporine did not prevent bombesin-induced GRP-R phosphorylation.	Tetradecanoylphorbol Acetate	21-57	gastrin releasing peptide receptor	Homo sapiens	98-103
7779996-6	1995	Independent of the differentiative state of the granulosa cells, TNF alpha suppressed FSH-stimulated tPA activity, but potentiated FSH-induced uPA activity in undifferentiated granulosa cells.	Tetradecanoylphorbol Acetate	101-104	tumor necrosis factor	Rattus norvegicus	65-74
7717978-5	1995	The tumour promoter and protein kinase C agonist, phorbol 12-myristate 13-acetate (PMA), also activated Raf-1, MEK-1, and MAP kinase in Ramos cells, but did not induce tyrosine phosphorylation of Shc or Shc/Grb2 association.	Tetradecanoylphorbol Acetate	83-86	growth factor receptor bound protein 2	Homo sapiens	207-211
7737290-2	1995	IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein kinase C (PKC)-activating phorbol 12-myristate 13-acetate (PMA) or with agents increasing cAMP, including prostaglandin E2.	Tetradecanoylphorbol Acetate	155-186	interferon gamma	Homo sapiens	0-9
7895329-7	1995	Downregulation of PKC by preincubation of VSM cells with 0.1 mumol/L phorbol 12-myristate 13-acetate (PMA) prevented osmolality-induced stimulation of the Na(+)-H+ exchanger (control plus PMA, 0.27 +/- 0.05 pH/min; high osmolality plus PMA, 0.33 +/- 0.08 pH/min; P &gt; .05).	Tetradecanoylphorbol Acetate	69-100	proline rich transmembrane protein 2	Homo sapiens	18-21
7895329-7	1995	Downregulation of PKC by preincubation of VSM cells with 0.1 mumol/L phorbol 12-myristate 13-acetate (PMA) prevented osmolality-induced stimulation of the Na(+)-H+ exchanger (control plus PMA, 0.27 +/- 0.05 pH/min; high osmolality plus PMA, 0.33 +/- 0.08 pH/min; P &gt; .05).	Tetradecanoylphorbol Acetate	102-105	proline rich transmembrane protein 2	Homo sapiens	18-21
7895329-7	1995	Downregulation of PKC by preincubation of VSM cells with 0.1 mumol/L phorbol 12-myristate 13-acetate (PMA) prevented osmolality-induced stimulation of the Na(+)-H+ exchanger (control plus PMA, 0.27 +/- 0.05 pH/min; high osmolality plus PMA, 0.33 +/- 0.08 pH/min; P &gt; .05).	Tetradecanoylphorbol Acetate	188-191	proline rich transmembrane protein 2	Homo sapiens	18-21
7895329-7	1995	Downregulation of PKC by preincubation of VSM cells with 0.1 mumol/L phorbol 12-myristate 13-acetate (PMA) prevented osmolality-induced stimulation of the Na(+)-H+ exchanger (control plus PMA, 0.27 +/- 0.05 pH/min; high osmolality plus PMA, 0.33 +/- 0.08 pH/min; P &gt; .05).	Tetradecanoylphorbol Acetate	188-191	proline rich transmembrane protein 2	Homo sapiens	18-21
7895690-6	1995	Phorbol 12-myristate 13 acetate (3 microM), tumor necrosis factor-alpha (100 ng/ml), and ionomycin (1 microM) also induced HSP synthesis.	Tetradecanoylphorbol Acetate	0-31	selenoprotein K	Rattus norvegicus	123-126
7744032-1	1995	The phorbol ester, 12-O-tetradecanoyl phorbol-13-acetate (TPA), known to induce murine glutathione S-transferase (GST) Ya, was examined for its effect on the expression of human GST alpha.	Tetradecanoylphorbol Acetate	19-56	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	87-121
7737290-2	1995	IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein kinase C (PKC)-activating phorbol 12-myristate 13-acetate (PMA) or with agents increasing cAMP, including prostaglandin E2.	Tetradecanoylphorbol Acetate	155-186	proline rich transmembrane protein 2	Homo sapiens	121-137
7744032-1	1995	The phorbol ester, 12-O-tetradecanoyl phorbol-13-acetate (TPA), known to induce murine glutathione S-transferase (GST) Ya, was examined for its effect on the expression of human GST alpha.	Tetradecanoylphorbol Acetate	58-61	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	87-121
7737290-2	1995	IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein kinase C (PKC)-activating phorbol 12-myristate 13-acetate (PMA) or with agents increasing cAMP, including prostaglandin E2.	Tetradecanoylphorbol Acetate	155-186	proline rich transmembrane protein 2	Homo sapiens	139-142
7737290-2	1995	IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein kinase C (PKC)-activating phorbol 12-myristate 13-acetate (PMA) or with agents increasing cAMP, including prostaglandin E2.	Tetradecanoylphorbol Acetate	188-191	interferon gamma	Homo sapiens	0-9
7737290-2	1995	IFN-gamma was secreted by the CTL clone in response to the Ca2+ ionophore ionomycin when used in conjunction with either protein kinase C (PKC)-activating phorbol 12-myristate 13-acetate (PMA) or with agents increasing cAMP, including prostaglandin E2.	Tetradecanoylphorbol Acetate	188-191	proline rich transmembrane protein 2	Homo sapiens	139-142
7699321-4	1995	This surface expression does not require de novo protein synthesis and lasts for only 1-2 h. Preformed CD40 ligand (CD40L) was not detected in any CD4+ CD45RA+ T cells, but &gt; 90% of all CD4+ T cells from the tonsil can be induced to express large amounts of CD40L on culture with phorbol myristate acetate and the calcium ionophore ionomycin.	Tetradecanoylphorbol Acetate	283-308	CD4 molecule	Homo sapiens	103-106
7547684-2	1995	In order to further understand the mechanism of IFN-gamma induction, we compared the regulation of IFN-gamma mRNA production after stimulation of NK cells with either B lymphocytes or phorbol myristate acetate (PMA)+ionomycin.	Tetradecanoylphorbol Acetate	184-209	interferon gamma	Mus musculus	99-108
7547686-6	1995	The strong inhibitory effect of DEX on naive CD4+ T cells stimulated via the alternative pathway was completely abrogated by activation of protein kinase C (PKC) with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	167-192	CD4 molecule	Homo sapiens	45-48
7890370-6	1995	THP-1 cells showed maximal activation by the LPS molecules after cell differentiation was induced by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	101-132	GLI family zinc finger 2	Homo sapiens	0-5
7615646-8	1995	The phorbol ester, PMA, up-regulated considerably the mRNA expression of TIMP-1 but had no effect on protein production.	Tetradecanoylphorbol Acetate	19-22	TIMP metallopeptidase inhibitor 1	Homo sapiens	73-79
7706493-4	1995	In F-nl, incubation with the agonists PMA, LPS, or IL-1 increased COX activity and protein expression of the inducible form of COX, COX-2, and these responses were inhibited by coincubation with dexamethasone.	Tetradecanoylphorbol Acetate	38-41	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
7699321-4	1995	This surface expression does not require de novo protein synthesis and lasts for only 1-2 h. Preformed CD40 ligand (CD40L) was not detected in any CD4+ CD45RA+ T cells, but &gt; 90% of all CD4+ T cells from the tonsil can be induced to express large amounts of CD40L on culture with phorbol myristate acetate and the calcium ionophore ionomycin.	Tetradecanoylphorbol Acetate	283-308	CD40 ligand	Homo sapiens	103-114
7699321-4	1995	This surface expression does not require de novo protein synthesis and lasts for only 1-2 h. Preformed CD40 ligand (CD40L) was not detected in any CD4+ CD45RA+ T cells, but &gt; 90% of all CD4+ T cells from the tonsil can be induced to express large amounts of CD40L on culture with phorbol myristate acetate and the calcium ionophore ionomycin.	Tetradecanoylphorbol Acetate	283-308	CD40 ligand	Homo sapiens	116-121
7699321-4	1995	This surface expression does not require de novo protein synthesis and lasts for only 1-2 h. Preformed CD40 ligand (CD40L) was not detected in any CD4+ CD45RA+ T cells, but &gt; 90% of all CD4+ T cells from the tonsil can be induced to express large amounts of CD40L on culture with phorbol myristate acetate and the calcium ionophore ionomycin.	Tetradecanoylphorbol Acetate	283-308	CD4 molecule	Homo sapiens	116-119
7659084-4	1995	We found that a functional NF-kappa B site in the ICAM-1 promoter, which can be activated by either 12-O-tetradecanoylphorbol-13-acetate or tumor necrosis factor-alpha (TNF alpha), is also the target for glucocorticoids.	Tetradecanoylphorbol Acetate	100-136	nuclear factor kappa B subunit 1	Homo sapiens	27-37
7536887-7	1995	Virtually all of the alterations in basal and insulin-induced phosphorylations associated with Cr(VI) treatment were also observed in cells treated with the protein kinase C (PKC) agonist phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	188-219	insulin	Homo sapiens	46-53
7706285-6	1995	HuT 78 and K-4 cells also expressed high levels of constitutively active NF kappa B, unlike Jurkat cells, which expressed high levels only upon activation with TNF or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	167-198	nuclear factor kappa B subunit 1	Homo sapiens	73-83
7533188-4	1995	Half of these TCCs were, however, capable of TGF-beta secretion and mRNA expression upon stimulation with PMA and the calcium inonphore A23187, suggesting a possible defect in activation through the TCR/CD3 pathway.	Tetradecanoylphorbol Acetate	106-109	transforming growth factor beta 1	Homo sapiens	45-53
7696349-4	1995	Chronic treatment of cells with 12-O-tetradecanoyl-phorbol 13-acetate marginally diminished the extent of erk2 stimulation, but had no influence on the OA-induced potentiation of heat-induced erk2 activity.	Tetradecanoylphorbol Acetate	32-69	mitogen-activated protein kinase 1	Homo sapiens	106-110
7896842-8	1995	NF-kappa B induction by PF-mediated photosensitization was not affected by the presence of N-acetyl-L-cysteine while strong inhibition was recorded when the induction was triggered by H2O2 or by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	195-226	nuclear factor kappa B subunit 1	Homo sapiens	0-10
7896842-10	1995	In comparison with other inducing treatments, such as phorbol 12-myristate 13-acetate or tumor necrosis factor alpha, the activation of NF-kappa B is slow, being optimal 120 min after treatment.	Tetradecanoylphorbol Acetate	54-85	nuclear factor kappa B subunit 1	Homo sapiens	136-146
7534132-6	1995	12-O-tetradecanoylphorbol-13-acetate (TPA), by which PKC was activated at first and downregulated in a late phase, gradually decreased c-kit mRNA in K562YO cells until 9 hours and then returned to the control level 24 hours after treatment.	Tetradecanoylphorbol Acetate	0-36	proline rich transmembrane protein 2	Homo sapiens	53-56
7534132-6	1995	12-O-tetradecanoylphorbol-13-acetate (TPA), by which PKC was activated at first and downregulated in a late phase, gradually decreased c-kit mRNA in K562YO cells until 9 hours and then returned to the control level 24 hours after treatment.	Tetradecanoylphorbol Acetate	0-36	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	135-140
7534132-6	1995	12-O-tetradecanoylphorbol-13-acetate (TPA), by which PKC was activated at first and downregulated in a late phase, gradually decreased c-kit mRNA in K562YO cells until 9 hours and then returned to the control level 24 hours after treatment.	Tetradecanoylphorbol Acetate	38-41	proline rich transmembrane protein 2	Homo sapiens	53-56
7534132-6	1995	12-O-tetradecanoylphorbol-13-acetate (TPA), by which PKC was activated at first and downregulated in a late phase, gradually decreased c-kit mRNA in K562YO cells until 9 hours and then returned to the control level 24 hours after treatment.	Tetradecanoylphorbol Acetate	38-41	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	135-140
7534132-7	1995	TPA also rapidly decreased c-kit protein level on the membranes.	Tetradecanoylphorbol Acetate	0-3	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	27-32
7534132-8	1995	In whole cells, c-kit protein was also decreased 6 hours after incubation with TPA.	Tetradecanoylphorbol Acetate	79-82	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	16-21
7612191-6	1995	PMA-induced differentiation of myeloid cells is accompanied by inhibition of uPA-PAI-1 internalization/degradation and the down-regulation of alpha 2-MR.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase	Homo sapiens	77-80
7890616-3	1995	We show here, the inhibitory effect of IL-13 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-triggered reactive oxygen intermediate production in human monocytes and the signals involved in this response.	Tetradecanoylphorbol Acetate	48-84	interleukin 13	Homo sapiens	39-44
7890616-3	1995	We show here, the inhibitory effect of IL-13 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-triggered reactive oxygen intermediate production in human monocytes and the signals involved in this response.	Tetradecanoylphorbol Acetate	86-89	interleukin 13	Homo sapiens	39-44
7890616-6	1995	Metabolic inhibitors were used to relate the first steps in signaling pathways to the inhibitory effect of IL-13 on TPA-triggered reactive oxygen intermediate production.	Tetradecanoylphorbol Acetate	116-119	interleukin 13	Homo sapiens	107-112
7890616-8	1995	Altogether these observations indicate that modulatory effect of IL-13 on the TPA-induced oxidative burst is the result of the intracellular cAMP accumulation through an inositol 1,4,5-trisphosphate-induced Ca2+ mobilization-dependent pathway.	Tetradecanoylphorbol Acetate	78-81	interleukin 13	Homo sapiens	65-70
7876252-5	1995	This conclusion was confirmed by the finding of phosphorylated wild-type p17 in the membrane fraction only after PMA treatment.	Tetradecanoylphorbol Acetate	113-116	family with sequence similarity 72 member B	Homo sapiens	73-76
7898939-1	1995	The product of the junB gene is a member of the AP-1 family of transcription factors that activate transcription by binding to TPA-responsive elements (TREs) within the promoters of target genes.	Tetradecanoylphorbol Acetate	127-130	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	19-23
7890622-10	1995	In parallel, the anti-PtdIns 4-kinase fully inhibited the activation of PLD by GTP gamma S and caused a 60% inhibition of PLD activation by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, indicating that elevated PtdIns-4,5-P2 levels are required for PLD activation.	Tetradecanoylphorbol Acetate	158-194	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	122-125
7890622-10	1995	In parallel, the anti-PtdIns 4-kinase fully inhibited the activation of PLD by GTP gamma S and caused a 60% inhibition of PLD activation by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, indicating that elevated PtdIns-4,5-P2 levels are required for PLD activation.	Tetradecanoylphorbol Acetate	158-194	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	122-125
7867590-5	1995	Secondly, in prolonged (4-day) treatments of MTLN (ER-positive) cells, low antiestrogen concentrations (nanomolar) decreased the basal AP-1 response by about 2 and increased the 12-O-tetradecanoyl-phorbol-13-acetate-stimulated AP-1 response by about 3-4.	Tetradecanoylphorbol Acetate	178-215	estrogen receptor 1	Homo sapiens	51-53
7532590-5	1995	However, a strong phosphorylation of the CD18-chain by preexposure to phorbol myristate acetate (PMA) coincided with an abolishment of both the beta 2-integrin-induced Ca2+ signal and the protein tyrosine phosphorylations.	Tetradecanoylphorbol Acetate	70-95	integrin subunit beta 2	Homo sapiens	41-45
7532590-5	1995	However, a strong phosphorylation of the CD18-chain by preexposure to phorbol myristate acetate (PMA) coincided with an abolishment of both the beta 2-integrin-induced Ca2+ signal and the protein tyrosine phosphorylations.	Tetradecanoylphorbol Acetate	97-100	integrin subunit beta 2	Homo sapiens	41-45
7867605-3	1995	Fibroblast growth factor-2, a potent mitogen for BAC cells, which acts through its tyrosine kinase receptor, also activates MAPK (EC50 = 0.3 in a TPA-insensitive manner, while exhibiting no detectable effect on BAC cell steroidogenesis.	Tetradecanoylphorbol Acetate	146-149	fibroblast growth factor 2	Bos taurus	0-26
7734622-0	1995	cAMP and PMA enhance the effects of IGF-I in the proliferation of endometrial adenocarcinoma cell line HEC-1-A by acting at the G1 phase of the cell cycle.	Tetradecanoylphorbol Acetate	9-12	insulin like growth factor 1	Homo sapiens	36-41
7734622-0	1995	cAMP and PMA enhance the effects of IGF-I in the proliferation of endometrial adenocarcinoma cell line HEC-1-A by acting at the G1 phase of the cell cycle.	Tetradecanoylphorbol Acetate	9-12	NDC80 kinetochore complex component	Homo sapiens	103-108
7734622-6	1995	The interaction of forskolin and PMA with IGF-I was then determined.	Tetradecanoylphorbol Acetate	33-36	insulin like growth factor 1	Homo sapiens	42-47
7789482-7	1995	NF-kappa B was rapidly activated by exposure of cells to interleukin-1 beta (IL-1 beta), phorbol myristate acetate (PMA), and tumour necrosis factor-alpha (TNF).	Tetradecanoylphorbol Acetate	89-114	nuclear factor kappa B subunit 1	Homo sapiens	0-10
7789482-7	1995	NF-kappa B was rapidly activated by exposure of cells to interleukin-1 beta (IL-1 beta), phorbol myristate acetate (PMA), and tumour necrosis factor-alpha (TNF).	Tetradecanoylphorbol Acetate	116-119	nuclear factor kappa B subunit 1	Homo sapiens	0-10
7875467-6	1995	Activation of PKC by phorbol myristate acetate also stimulated IL-8 production; however, the effects of IL-1 beta or TNF-alpha did not require PKC, as shown by the PKC inhibitor staurosporin or PKC depletion.	Tetradecanoylphorbol Acetate	21-46	proline rich transmembrane protein 2	Homo sapiens	14-17
7875467-6	1995	Activation of PKC by phorbol myristate acetate also stimulated IL-8 production; however, the effects of IL-1 beta or TNF-alpha did not require PKC, as shown by the PKC inhibitor staurosporin or PKC depletion.	Tetradecanoylphorbol Acetate	21-46	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
7533140-5	1995	Incubation of BAEC with phorbol 12-myristate 13-acetate (100 nmol/L) for 24 hours, which downregulates PKC, increased ecNOS mRNA expression.	Tetradecanoylphorbol Acetate	24-55	nitric oxide synthase 3	Bos taurus	118-123
7794816-6	1995	In keratinocytes transfected with a chloramphenicol acetyltransferase construct containing the -1059 to +138 base pair TNF-alpha promoter, increased promoter activity was observed upon stimulation with PMA and DMSO.	Tetradecanoylphorbol Acetate	202-205	tumor necrosis factor	Mus musculus	119-128
7794816-10	1995	Co-stimulation with PMA and NiSO4 induced a marked increase in TNF-alpha mRNA over that obtained with each agent alone.	Tetradecanoylphorbol Acetate	20-23	tumor necrosis factor	Mus musculus	63-72
7768986-6	1995	12-O-Tetradecanoylphorbol-13-acetate, a protein kinase C (PKC)-activating phorbol ester, significantly reduced the dexamethasone-induced enhancement of IP3 formation stimulated by vasopressin, angiotensin II or NaF 4 alpha-Phorbol-12, 13-didecanoate, a PKC-nonactivating phorbol ester, had little effect on the enhancement by dexamethasone.	Tetradecanoylphorbol Acetate	0-36	arginine vasopressin	Rattus norvegicus	180-191
7768986-6	1995	12-O-Tetradecanoylphorbol-13-acetate, a protein kinase C (PKC)-activating phorbol ester, significantly reduced the dexamethasone-induced enhancement of IP3 formation stimulated by vasopressin, angiotensin II or NaF 4 alpha-Phorbol-12, 13-didecanoate, a PKC-nonactivating phorbol ester, had little effect on the enhancement by dexamethasone.	Tetradecanoylphorbol Acetate	0-36	angiotensinogen	Rattus norvegicus	193-207
7860638-10	1995	When the effects of other nucleotides were examined, TPA was found to cause significantly greater inhibition of the response to the P2Y-receptor agonists, ADP and 2-methylthioATP, than the response to the P2U-receptor agonist, UTP.	Tetradecanoylphorbol Acetate	53-56	purinergic receptor P2Y1	Rattus norvegicus	132-135
7860643-9	1995	Phorbol 12-myristate 13-acetate (PMA) is also capable of inducing ERK phosphorylation, albeit to a lasser degree.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 1	Homo sapiens	66-69
7860643-9	1995	Phorbol 12-myristate 13-acetate (PMA) is also capable of inducing ERK phosphorylation, albeit to a lasser degree.	Tetradecanoylphorbol Acetate	33-36	mitogen-activated protein kinase 1	Homo sapiens	66-69
7860643-11	1995	The role of protein kinase C (PKC) in the EGF-stimulated ERK signaling pathway was further examined by inhibition of PKC with the staurosporine analog, CGP41251, and by down-regulation of PKC via chronic treatment with PMA.	Tetradecanoylphorbol Acetate	219-222	mitogen-activated protein kinase 1	Homo sapiens	57-60
7883982-7	1995	Inhibition of protein kinase C completely blocked PMA-stimulated induction of PAI-2 mRNA in both cell types and inhibited the AII-stimulated increase in RASMC by 98.6 +/- 2.8%.	Tetradecanoylphorbol Acetate	50-53	serpin family B member 2	Rattus norvegicus	78-83
7772573-6	1995	Pretreatment with phorbol-12-myristate-13-acetate (PMA), a protein kinase C (PKC) activator, significantly resulted in reduction of the descending shoulder of BK-induced increase in [Ca2+]i.	Tetradecanoylphorbol Acetate	18-49	proline rich transmembrane protein 2	Homo sapiens	59-75
7772573-6	1995	Pretreatment with phorbol-12-myristate-13-acetate (PMA), a protein kinase C (PKC) activator, significantly resulted in reduction of the descending shoulder of BK-induced increase in [Ca2+]i.	Tetradecanoylphorbol Acetate	18-49	proline rich transmembrane protein 2	Homo sapiens	77-80
7772573-6	1995	Pretreatment with phorbol-12-myristate-13-acetate (PMA), a protein kinase C (PKC) activator, significantly resulted in reduction of the descending shoulder of BK-induced increase in [Ca2+]i.	Tetradecanoylphorbol Acetate	18-49	kininogen 1	Homo sapiens	159-161
7772573-6	1995	Pretreatment with phorbol-12-myristate-13-acetate (PMA), a protein kinase C (PKC) activator, significantly resulted in reduction of the descending shoulder of BK-induced increase in [Ca2+]i.	Tetradecanoylphorbol Acetate	51-54	proline rich transmembrane protein 2	Homo sapiens	59-75
7772573-6	1995	Pretreatment with phorbol-12-myristate-13-acetate (PMA), a protein kinase C (PKC) activator, significantly resulted in reduction of the descending shoulder of BK-induced increase in [Ca2+]i.	Tetradecanoylphorbol Acetate	51-54	proline rich transmembrane protein 2	Homo sapiens	77-80
7772573-6	1995	Pretreatment with phorbol-12-myristate-13-acetate (PMA), a protein kinase C (PKC) activator, significantly resulted in reduction of the descending shoulder of BK-induced increase in [Ca2+]i.	Tetradecanoylphorbol Acetate	51-54	kininogen 1	Homo sapiens	159-161
7772573-8	1995	Furthermore, the BK-induced [45Ca] uptake was inhibited by EGTA and PMA.	Tetradecanoylphorbol Acetate	68-71	kininogen 1	Homo sapiens	17-19
7869038-7	1995	Cotransfection of gamma B*CaM-K with the IL-2 promoter construct downregulated its transcription in response to stimulation with ionomycin and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	170-173	interleukin 2	Homo sapiens	41-45
7869038-7	1995	Cotransfection of gamma B*CaM-K with the IL-2 promoter construct downregulated its transcription in response to stimulation with ionomycin and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	143-168	interleukin 2	Homo sapiens	41-45
7878013-7	1995	Interestingly, the degree of apoptosis of CD4+ T cells by crosslinking of CD4 molecules via a combination of gp120, anti-gp120, and goat anti-mouse IgG was significantly greater for T cells primed with PMA-treated Mo than for unprimed T cells.	Tetradecanoylphorbol Acetate	202-205	CD4 molecule	Homo sapiens	42-45
7776154-4	1995	The PA produced by Gin-1 cells was determined to be urokinase PA (uPA), as preincubation of Gin-1 conditioned medium with anti-uPA antiserum completely inhibited the PA activity while that with anti-tPA antiserum had no inhibitory effect.	Tetradecanoylphorbol Acetate	199-202	plasminogen activator, urokinase	Homo sapiens	52-64
7776154-4	1995	The PA produced by Gin-1 cells was determined to be urokinase PA (uPA), as preincubation of Gin-1 conditioned medium with anti-uPA antiserum completely inhibited the PA activity while that with anti-tPA antiserum had no inhibitory effect.	Tetradecanoylphorbol Acetate	199-202	plasminogen activator, urokinase	Homo sapiens	66-69
7532282-1	1995	We identified I kappa B alpha/MAD-3 as an immediate-early gene in human monocytes that is expressed in response to a variety of signals, including adhesion, lipopolysaccharide, and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	181-206	NFKB inhibitor alpha	Homo sapiens	14-29
7876145-5	1995	Down-regulation of PKC by prolonged treatment with 4 beta-phorbol 12-myristate 13-acetate also abolished EGF- and PDGF-stimulated phosphatidylbutanol formation.	Tetradecanoylphorbol Acetate	51-89	protein kinase C, alpha	Mus musculus	19-22
7532282-1	1995	We identified I kappa B alpha/MAD-3 as an immediate-early gene in human monocytes that is expressed in response to a variety of signals, including adhesion, lipopolysaccharide, and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	181-206	NFKB inhibitor alpha	Homo sapiens	30-35
7538636-4	1995	The treatment of multidrug-resistant cells with 100 nM PMA for 2 hours resulted in the activation not of PKC-zeta but of PKC-alpha, with concomitant decrease in vincristine accumulation and increase in P-glycoprotein phosphorylation.	Tetradecanoylphorbol Acetate	55-58	protein kinase C alpha	Homo sapiens	121-130
7538636-5	1995	The exposure of multidrug-resistant cells to 100 nM PMA for 24 hours induced down-regulation not of PKC-zeta but of PKC-alpha, with concurrent decrease in vincristine accumulation, and reduced but still increased P-glycoprotein phosphorylation.	Tetradecanoylphorbol Acetate	52-55	protein kinase C alpha	Homo sapiens	116-125
7878013-7	1995	Interestingly, the degree of apoptosis of CD4+ T cells by crosslinking of CD4 molecules via a combination of gp120, anti-gp120, and goat anti-mouse IgG was significantly greater for T cells primed with PMA-treated Mo than for unprimed T cells.	Tetradecanoylphorbol Acetate	202-205	CD4 molecule	Homo sapiens	74-77
7867787-2	1995	While both mRNA levels were increased after stimulation by tumor necrosis factor alpha (TNF alpha), phorbol ester (PMA) and cycloheximide, they were inhibited by butyrate at 2.5 to 25 mM.	Tetradecanoylphorbol Acetate	115-118	tumor necrosis factor	Homo sapiens	59-86
7836748-5	1995	The most potent effects were observed with IL-4 and the phorbol ester, O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C. IL-4 also partly inhibited TGF-beta 1 and forskolin-induced apoptosis.	Tetradecanoylphorbol Acetate	106-109	interleukin 4	Homo sapiens	146-150
7836748-5	1995	The most potent effects were observed with IL-4 and the phorbol ester, O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C. IL-4 also partly inhibited TGF-beta 1 and forskolin-induced apoptosis.	Tetradecanoylphorbol Acetate	106-109	transforming growth factor beta 1	Homo sapiens	173-183
7530739-7	1995	CD40-L expression on newborn T lymphocytes was induced on T cell lines generated in the presence of PHA and maintained with IL-2 following further stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	164-167	CD40 ligand	Homo sapiens	0-6
7857975-6	1995	In contrast, extracts from cultured human umbilical vein endothelial cells challenged with 20 nM phorbol myristate acetate (PMA) showed an increase in COX-2 immunoreactivity related both to the increase in enzyme activity and the variations observed by Western blot analysis.	Tetradecanoylphorbol Acetate	97-122	prostaglandin-endoperoxide synthase 2	Homo sapiens	151-156
7857975-6	1995	In contrast, extracts from cultured human umbilical vein endothelial cells challenged with 20 nM phorbol myristate acetate (PMA) showed an increase in COX-2 immunoreactivity related both to the increase in enzyme activity and the variations observed by Western blot analysis.	Tetradecanoylphorbol Acetate	124-127	prostaglandin-endoperoxide synthase 2	Homo sapiens	151-156
7857271-3	1995	In long term cultures, 1-100 nM TPA stimulated ACTH secretion dose-dependently, whereas 500nM A23187 inhibited ACTH secretion completely.	Tetradecanoylphorbol Acetate	32-35	proopiomelanocortin	Homo sapiens	47-51
7857297-1	1995	In Spodoptera frugiperda (Sf9) insect cells infected with a recombinant baculovirus carrying a gene construct encoding human CD4 endocytosis of CD4 is induced after stimulation with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	182-213	CD4 molecule	Homo sapiens	125-128
7857297-1	1995	In Spodoptera frugiperda (Sf9) insect cells infected with a recombinant baculovirus carrying a gene construct encoding human CD4 endocytosis of CD4 is induced after stimulation with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	182-213	CD4 molecule	Homo sapiens	144-147
7539602-6	1995	production was assessed by nitrite accumulation after iNOS induction by coadministration of phorbol 12-myristate 13-acetate (PMA) and lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	92-123	nitric oxide synthase 2	Rattus norvegicus	54-58
7857297-1	1995	In Spodoptera frugiperda (Sf9) insect cells infected with a recombinant baculovirus carrying a gene construct encoding human CD4 endocytosis of CD4 is induced after stimulation with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	215-218	CD4 molecule	Homo sapiens	125-128
7857271-4	1995	When the cells were incubated with 10nM TPA plus 500 nM A23187, the inhibitory action of A23187 on ACTH secretion was suppressed by TPA.	Tetradecanoylphorbol Acetate	40-43	proopiomelanocortin	Homo sapiens	99-103
7857297-1	1995	In Spodoptera frugiperda (Sf9) insect cells infected with a recombinant baculovirus carrying a gene construct encoding human CD4 endocytosis of CD4 is induced after stimulation with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	215-218	CD4 molecule	Homo sapiens	144-147
7857271-4	1995	When the cells were incubated with 10nM TPA plus 500 nM A23187, the inhibitory action of A23187 on ACTH secretion was suppressed by TPA.	Tetradecanoylphorbol Acetate	132-135	proopiomelanocortin	Homo sapiens	99-103
7748537-4	1995	The release of interleukin-4 (IL-4) by PBMC stimulated with the isolated L. donovani antigen fractions was measured after treatment with phorbol-myristate-acetate and ionomycin.	Tetradecanoylphorbol Acetate	137-162	interleukin 4	Homo sapiens	15-28
7864072-3	1995	TNF-alpha, IL-1 beta and phorbol myristate acetate (PMA) treatment increased AP-1 and NF kappa B DNA binding by up to 200% but decreased CREB binding (38%) over a 60-min time course.	Tetradecanoylphorbol Acetate	25-50	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-81
7864072-3	1995	TNF-alpha, IL-1 beta and phorbol myristate acetate (PMA) treatment increased AP-1 and NF kappa B DNA binding by up to 200% but decreased CREB binding (38%) over a 60-min time course.	Tetradecanoylphorbol Acetate	25-50	nuclear factor kappa B subunit 1	Homo sapiens	86-96
7864072-3	1995	TNF-alpha, IL-1 beta and phorbol myristate acetate (PMA) treatment increased AP-1 and NF kappa B DNA binding by up to 200% but decreased CREB binding (38%) over a 60-min time course.	Tetradecanoylphorbol Acetate	52-55	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-81
7748537-4	1995	The release of interleukin-4 (IL-4) by PBMC stimulated with the isolated L. donovani antigen fractions was measured after treatment with phorbol-myristate-acetate and ionomycin.	Tetradecanoylphorbol Acetate	137-162	interleukin 4	Homo sapiens	30-34
7864072-3	1995	TNF-alpha, IL-1 beta and phorbol myristate acetate (PMA) treatment increased AP-1 and NF kappa B DNA binding by up to 200% but decreased CREB binding (38%) over a 60-min time course.	Tetradecanoylphorbol Acetate	52-55	nuclear factor kappa B subunit 1	Homo sapiens	86-96
7736562-3	1995	Pretreatment of TSMCs with phorbol 12-myristate 13-acetate (PMA, 1 microM) for 30 min blocked the ET-1-induced IP3 formation and Ca2+ mobilization.	Tetradecanoylphorbol Acetate	27-58	endothelin 1	Canis lupus familiaris	98-102
7736562-6	1995	Prior treatment of TSMCs with staurosporine (1 microM), a PKC inhibitor, inhibited the ability of PMA to attenuate ET-1-induced responses, suggesting that the inhibitory effect of PMA is mediated through the activation of PKC.	Tetradecanoylphorbol Acetate	98-101	endothelin 1	Canis lupus familiaris	115-119
7736562-7	1995	In parallel with the effect of PMA on the ET-1-induced IP3 formation and Ca2+ mobilization, a change of PKC activity was observed in TSMCs.	Tetradecanoylphorbol Acetate	31-34	endothelin 1	Canis lupus familiaris	42-46
7736562-3	1995	Pretreatment of TSMCs with phorbol 12-myristate 13-acetate (PMA, 1 microM) for 30 min blocked the ET-1-induced IP3 formation and Ca2+ mobilization.	Tetradecanoylphorbol Acetate	60-63	endothelin 1	Canis lupus familiaris	98-102
7736562-5	1995	Following preincubation, ET-1-induced Ca2+ mobilization recovered with time and reached the same extent of control cells within 48 h. The concentrations of PMA that gave half-maximal inhibition (-logEC50) of ET-1-induced IP3 formation and increase in [Ca2+]i were 8.6 and 8.4 M, respectively.	Tetradecanoylphorbol Acetate	156-159	endothelin 1	Canis lupus familiaris	25-29
7736562-5	1995	Following preincubation, ET-1-induced Ca2+ mobilization recovered with time and reached the same extent of control cells within 48 h. The concentrations of PMA that gave half-maximal inhibition (-logEC50) of ET-1-induced IP3 formation and increase in [Ca2+]i were 8.6 and 8.4 M, respectively.	Tetradecanoylphorbol Acetate	156-159	endothelin 1	Canis lupus familiaris	208-212
7834638-4	1995	We show that p53-independent induction of WAF1/CIP1 occurs in human leukemia cells treated with 12-O-tetradecanoylphorbol-13-acetate, okadaic acid, or IFN-gamma but not with retinoic acid, vitamin D3, or DMSO.	Tetradecanoylphorbol Acetate	96-132	tumor protein p53	Homo sapiens	13-16
7544678-3	1995	The inhibitory effect of TPA on histamine-stimulated adenylate cyclase was enhanced by the presence of Ca2+, but decreased in a concentration-dependent manner by anti-peptide antibody to protein kinase C alpha, but not to protein kinase C epsilon.	Tetradecanoylphorbol Acetate	25-28	protein kinase C alpha	Homo sapiens	187-209
7834638-4	1995	We show that p53-independent induction of WAF1/CIP1 occurs in human leukemia cells treated with 12-O-tetradecanoylphorbol-13-acetate, okadaic acid, or IFN-gamma but not with retinoic acid, vitamin D3, or DMSO.	Tetradecanoylphorbol Acetate	96-132	cyclin dependent kinase inhibitor 1A	Homo sapiens	42-46
7834638-4	1995	We show that p53-independent induction of WAF1/CIP1 occurs in human leukemia cells treated with 12-O-tetradecanoylphorbol-13-acetate, okadaic acid, or IFN-gamma but not with retinoic acid, vitamin D3, or DMSO.	Tetradecanoylphorbol Acetate	96-132	cyclin dependent kinase inhibitor 1A	Homo sapiens	47-51
16695971-6	1995	Cells treated with HGF, DMSO, or TPA were also positive for cMET.Conclusions-These data suggest that HGF induced partial monocytic differentiation in HL60 cells.	Tetradecanoylphorbol Acetate	33-36	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	60-64
7835292-5	1995	The effects of TPA were mimicked by another PKC activator, phorbol 12,13-dibutyrate, but not by a phorbol ester that fails to activate PKC, 4 alpha-phorbol 12,13-didecanoate, and were reversed by staurosporine, a PKC inhibitor.	Tetradecanoylphorbol Acetate	15-18	proline rich transmembrane protein 2	Homo sapiens	44-47
7835292-6	1995	The TPA actions seem, therefore, to be PKC-mediated.	Tetradecanoylphorbol Acetate	4-7	proline rich transmembrane protein 2	Homo sapiens	39-42
7835292-10	1995	The TPA-mitogenic and antimitogenic effects could not be mimicked by 4 alpha-phorbol-12,13-didecanoate and were reversed by staurosporine, thus indicating a PKC-mediated pathway for such TPA actions.	Tetradecanoylphorbol Acetate	4-7	proline rich transmembrane protein 2	Homo sapiens	157-160
7835292-10	1995	The TPA-mitogenic and antimitogenic effects could not be mimicked by 4 alpha-phorbol-12,13-didecanoate and were reversed by staurosporine, thus indicating a PKC-mediated pathway for such TPA actions.	Tetradecanoylphorbol Acetate	187-190	proline rich transmembrane protein 2	Homo sapiens	157-160
7843281-5	1995	Additionally, a dose-dependent loss of cell surface thrombin receptor is induced by phorbol 12-myristate 13-acetate (PMA), suggesting that thrombin receptor undergoes heterologous internalization in response to PMA.	Tetradecanoylphorbol Acetate	84-115	coagulation factor II, thrombin	Homo sapiens	52-60
7843281-5	1995	Additionally, a dose-dependent loss of cell surface thrombin receptor is induced by phorbol 12-myristate 13-acetate (PMA), suggesting that thrombin receptor undergoes heterologous internalization in response to PMA.	Tetradecanoylphorbol Acetate	84-115	coagulation factor II, thrombin	Homo sapiens	139-147
7843281-5	1995	Additionally, a dose-dependent loss of cell surface thrombin receptor is induced by phorbol 12-myristate 13-acetate (PMA), suggesting that thrombin receptor undergoes heterologous internalization in response to PMA.	Tetradecanoylphorbol Acetate	117-120	coagulation factor II, thrombin	Homo sapiens	52-60
7843281-5	1995	Additionally, a dose-dependent loss of cell surface thrombin receptor is induced by phorbol 12-myristate 13-acetate (PMA), suggesting that thrombin receptor undergoes heterologous internalization in response to PMA.	Tetradecanoylphorbol Acetate	117-120	coagulation factor II, thrombin	Homo sapiens	139-147
7622191-2	1995	TG plus phorbol myristate acetate (PMA) but not TG alone induced IL-2 in Jurkat T cells, suggesting that TG had no effect on protein kinase C (PKC).	Tetradecanoylphorbol Acetate	8-33	interleukin 2	Homo sapiens	65-69
7622191-2	1995	TG plus phorbol myristate acetate (PMA) but not TG alone induced IL-2 in Jurkat T cells, suggesting that TG had no effect on protein kinase C (PKC).	Tetradecanoylphorbol Acetate	35-38	interleukin 2	Homo sapiens	65-69
7544679-5	1995	The PKC activator TPA amplifies the response of mast cells to human GRF, shifting the dose-response curve to the left.	Tetradecanoylphorbol Acetate	18-21	growth hormone releasing hormone	Homo sapiens	68-71
7529802-6	1995	Second, preincubation of HUVEC with known PAF-inducing agents PMA, H2O2, and thrombin, followed by fixation, enhanced neutrophil H2O2 release in response to TNF.	Tetradecanoylphorbol Acetate	62-65	tumor necrosis factor	Homo sapiens	157-160
7768542-2	1995	These unfractionated thymocytes could be selectively expanded in vitro by stimulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) and PHA in the presence of IL-2.	Tetradecanoylphorbol Acetate	129-132	interleukin 2	Homo sapiens	161-165
7754798-1	1995	Biosynthesis of bone sialoprotein (BSP) by a human osteoclastic cell line (FLG 29.1) during its differentiation induced by phorbol 12-myristate 13-acetate (TPA) was studied using metabolic radiolabeling experiments.	Tetradecanoylphorbol Acetate	123-154	integrin binding sialoprotein	Homo sapiens	16-33
7754798-1	1995	Biosynthesis of bone sialoprotein (BSP) by a human osteoclastic cell line (FLG 29.1) during its differentiation induced by phorbol 12-myristate 13-acetate (TPA) was studied using metabolic radiolabeling experiments.	Tetradecanoylphorbol Acetate	123-154	integrin binding sialoprotein	Homo sapiens	35-38
7754798-1	1995	Biosynthesis of bone sialoprotein (BSP) by a human osteoclastic cell line (FLG 29.1) during its differentiation induced by phorbol 12-myristate 13-acetate (TPA) was studied using metabolic radiolabeling experiments.	Tetradecanoylphorbol Acetate	156-159	integrin binding sialoprotein	Homo sapiens	16-33
7754798-1	1995	Biosynthesis of bone sialoprotein (BSP) by a human osteoclastic cell line (FLG 29.1) during its differentiation induced by phorbol 12-myristate 13-acetate (TPA) was studied using metabolic radiolabeling experiments.	Tetradecanoylphorbol Acetate	156-159	integrin binding sialoprotein	Homo sapiens	35-38
7754798-3	1995	One of the major glycoproteins synthesized by the TPA-treated FLG 29.1 cells was sulfated, had an identical electrophoretic mobility to purified BSP, and could be immunoprecipitated with a specific antibody against human BSP (LF 6).	Tetradecanoylphorbol Acetate	50-53	integrin binding sialoprotein	Homo sapiens	145-148
7754798-3	1995	One of the major glycoproteins synthesized by the TPA-treated FLG 29.1 cells was sulfated, had an identical electrophoretic mobility to purified BSP, and could be immunoprecipitated with a specific antibody against human BSP (LF 6).	Tetradecanoylphorbol Acetate	50-53	integrin binding sialoprotein	Homo sapiens	221-224
7754798-5	1995	Furthermore, mRNA for BSP was also detected in TPA-treated FLG 29.1 cells by RNA-polymerase chain reaction.	Tetradecanoylphorbol Acetate	47-50	integrin binding sialoprotein	Homo sapiens	22-25
7754798-7	1995	Immunocytochemistry using an anti-BSP antibody showed a prominent paranuclear (suggestive of Golgi apparatus) localization of BSP in the TPA-treated FLG 29.1 cells after permeabilization, while untreated cells were not significantly immunostained.	Tetradecanoylphorbol Acetate	137-140	integrin binding sialoprotein	Homo sapiens	34-37
7754798-7	1995	Immunocytochemistry using an anti-BSP antibody showed a prominent paranuclear (suggestive of Golgi apparatus) localization of BSP in the TPA-treated FLG 29.1 cells after permeabilization, while untreated cells were not significantly immunostained.	Tetradecanoylphorbol Acetate	137-140	integrin binding sialoprotein	Homo sapiens	126-129
7754798-8	1995	Localization of BSP at the plasma membrane was also demonstrated in the TPA-treated FLG 29.1 cells by the fluorescence-activated cell sorting analysis.	Tetradecanoylphorbol Acetate	72-75	integrin binding sialoprotein	Homo sapiens	16-19
7754798-9	1995	Since TPA has been demonstrated to induce expression of various osteoclastic characteristics in FLG 29.1 cells, induction of BSP expression by TPA suggests that the protein may play a role during the differentiation process of osteoclasts or in functions of differentiated osteoclasts.	Tetradecanoylphorbol Acetate	143-146	integrin binding sialoprotein	Homo sapiens	125-128
7768335-3	1995	The induction of the VIP mRNA was enhanced by the simultaneous treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	78-114	vasoactive intestinal peptide	Rattus norvegicus	21-24
7853198-2	1995	Combined treatment of human umbilical endothelial cells with TNF-alpha and the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed the TNF-alpha-induced production of IL-1 alpha.	Tetradecanoylphorbol Acetate	112-148	tumor necrosis factor	Homo sapiens	170-179
7853198-2	1995	Combined treatment of human umbilical endothelial cells with TNF-alpha and the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed the TNF-alpha-induced production of IL-1 alpha.	Tetradecanoylphorbol Acetate	150-153	tumor necrosis factor	Homo sapiens	61-70
7853198-2	1995	Combined treatment of human umbilical endothelial cells with TNF-alpha and the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed the TNF-alpha-induced production of IL-1 alpha.	Tetradecanoylphorbol Acetate	150-153	tumor necrosis factor	Homo sapiens	170-179
7853198-4	1995	Pretreatment with TPA for 15 min was enough to suppress the TNF-alpha-induced IL-1 alpha production.	Tetradecanoylphorbol Acetate	18-21	tumor necrosis factor	Homo sapiens	60-69
7853198-6	1995	Stimulation of cell-associated IL-1 alpha production by IL-1 beta or lipopolysaccharide was also inhibited by pretreatment with the PKC activator TPA, aplysiatoxin or teleocidin.	Tetradecanoylphorbol Acetate	146-149	interleukin 1 beta	Homo sapiens	56-65
7853198-8	1995	The present work indicates that the production of cell-associated IL-1 alpha stimulated by TNF-alpha, IL-1 beta or lipopolysaccharide is inhibited by treatment with TPA, aplysiatoxin or teleocidin.	Tetradecanoylphorbol Acetate	165-168	tumor necrosis factor	Homo sapiens	91-100
7853198-8	1995	The present work indicates that the production of cell-associated IL-1 alpha stimulated by TNF-alpha, IL-1 beta or lipopolysaccharide is inhibited by treatment with TPA, aplysiatoxin or teleocidin.	Tetradecanoylphorbol Acetate	165-168	interleukin 1 beta	Homo sapiens	102-111
7851022-13	1995	Stimulation with phytohaemagglutinin (PHA) and phorbol myristate acetate (PMA) induced most TCC to produce higher amounts of TNF-alpha, IL-2 and IL-6.	Tetradecanoylphorbol Acetate	47-72	tumor necrosis factor	Homo sapiens	125-134
7851022-13	1995	Stimulation with phytohaemagglutinin (PHA) and phorbol myristate acetate (PMA) induced most TCC to produce higher amounts of TNF-alpha, IL-2 and IL-6.	Tetradecanoylphorbol Acetate	47-72	interleukin 2	Homo sapiens	136-140
7851022-13	1995	Stimulation with phytohaemagglutinin (PHA) and phorbol myristate acetate (PMA) induced most TCC to produce higher amounts of TNF-alpha, IL-2 and IL-6.	Tetradecanoylphorbol Acetate	47-72	interleukin 6	Homo sapiens	145-149
7851022-13	1995	Stimulation with phytohaemagglutinin (PHA) and phorbol myristate acetate (PMA) induced most TCC to produce higher amounts of TNF-alpha, IL-2 and IL-6.	Tetradecanoylphorbol Acetate	74-77	tumor necrosis factor	Homo sapiens	125-134
7851022-13	1995	Stimulation with phytohaemagglutinin (PHA) and phorbol myristate acetate (PMA) induced most TCC to produce higher amounts of TNF-alpha, IL-2 and IL-6.	Tetradecanoylphorbol Acetate	74-77	interleukin 2	Homo sapiens	136-140
7851022-13	1995	Stimulation with phytohaemagglutinin (PHA) and phorbol myristate acetate (PMA) induced most TCC to produce higher amounts of TNF-alpha, IL-2 and IL-6.	Tetradecanoylphorbol Acetate	74-77	interleukin 6	Homo sapiens	145-149
7830075-1	1995	Correlation between translocation and down-regulation of conventional protein kinase C alpha (cPKC alpha) and new PKC delta (nPKC delta) induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) at different time courses (5 min, 30 min, 1 h, 3 h, 6 h, 10 h, 17 h, and 24 h) was studied in C6 glioma cells.	Tetradecanoylphorbol Acetate	186-189	protein kinase C alpha	Homo sapiens	70-92
7869773-4	1995	Stimulation with phorbol 12-myristate 13-acetate (PMA) dramatically increased the expression of megakaryocyte-related markers such as HPL-3, J15, Pit-1, Y2/51 and AN51 in MEG-A2 cells.	Tetradecanoylphorbol Acetate	17-48	POU class 1 homeobox 1	Homo sapiens	146-151
7768335-3	1995	The induction of the VIP mRNA was enhanced by the simultaneous treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	116-119	vasoactive intestinal peptide	Rattus norvegicus	21-24
7870033-5	1995	After translocation, PKC-alpha, -delta, -eta, and -epsilon were down-regulated; the down-regulation of PKC-epsilon contrasts with its retention after phorbol-12-myristate-13-acetate or bryostatin treatment.	Tetradecanoylphorbol Acetate	150-181	protein kinase C, alpha	Mus musculus	21-58
7768335-4	1995	PC12 cells stimulated with forskolin plus TPA released immunoreactive VIP.	Tetradecanoylphorbol Acetate	42-45	vasoactive intestinal peptide	Rattus norvegicus	70-73
7480798-0	1995	Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis.	Tetradecanoylphorbol Acetate	196-221	interleukin 1 beta	Homo sapiens	0-18
7480798-0	1995	Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis.	Tetradecanoylphorbol Acetate	223-226	interleukin 1 beta	Homo sapiens	0-18
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Tetradecanoylphorbol Acetate	94-97	interleukin 1 beta	Homo sapiens	0-18
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Tetradecanoylphorbol Acetate	94-97	interleukin 1 beta	Homo sapiens	20-29
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Tetradecanoylphorbol Acetate	94-97	interleukin 1 beta	Homo sapiens	132-141
7833348-4	1995	The TPA effect could be mimicked by oleoylacetylglycerol and exogenous phospholipase C. Northern and Western blot analysis indicate that C6 cells express the GLYT1 glycine transporter.	Tetradecanoylphorbol Acetate	4-7	solute carrier family 6 member 9	Homo sapiens	158-163
7624733-1	1995	The human monocytic leukaemia cell line THP-1 was induced to differentiate to macrophage-like cells by the addition of phorbol myristoyl acetate (PMA).	Tetradecanoylphorbol Acetate	146-149	GLI family zinc finger 2	Homo sapiens	40-45
7879050-0	1995	Effect of rapamycin on the in vitro release of soluble interleukin-2 receptor by phytohemagglutinin, phorbol myristate acetate, and ionomycin-activated peripheral blood mononuclear cells.	Tetradecanoylphorbol Acetate	101-126	interleukin 2	Homo sapiens	55-68
7874691-3	1995	In HeLa cells farnesol caused translocation of PKC from membrane fraction to cytosol after 1h of incubation and also prevented PMA-stimulated induction of PKC translocation from cytosol to membranes.	Tetradecanoylphorbol Acetate	127-130	proline rich transmembrane protein 2	Homo sapiens	155-158
7833348-5	1995	Incubation of COS cells transiently transfected with a full-length clone of the GLYT1 transporter in the presence of TPA, produces a decrease in glycine uptake.	Tetradecanoylphorbol Acetate	117-120	solute carrier family 6 member 9	Homo sapiens	80-85
7828717-2	1995	The enzyme activity and protein level of PLC-gamma 1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-gamma 2 were not altered.	Tetradecanoylphorbol Acetate	181-212	phospholipase C gamma 1	Homo sapiens	41-52
7828717-2	1995	The enzyme activity and protein level of PLC-gamma 1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-gamma 2 were not altered.	Tetradecanoylphorbol Acetate	214-217	phospholipase C gamma 1	Homo sapiens	41-52
7835696-5	1995	Electrophoretic mobility shift assays and mutational analyses suggest that the promoter site is bound by nuclear protein complexes containing cAMP-independent members of the ATF/CREB family of proteins and c-Jun, and are functionally distinct from the AP1-related TPA-response element (TRE) binding activity.	Tetradecanoylphorbol Acetate	264-267	cAMP responsive element binding protein 1	Mus musculus	178-182
7695161-2	1995	Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes.	Tetradecanoylphorbol Acetate	29-54	integrin subunit beta 2	Homo sapiens	156-160
7811990-5	1995	Based on densitometry of immune precipitates, CD43 levels were decreased 42% +/- 6% in neutrophils treated for 10 minutes with opsonized zymosan and decreased 70% +/- 3% in neutrophils treated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	198-229	sialophorin	Homo sapiens	46-50
7695161-2	1995	Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes.	Tetradecanoylphorbol Acetate	56-59	integrin subunit beta 2	Homo sapiens	156-160
7695161-8	1995	The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 also showed inhibitory effects on the increase in intracellular fluorescence intensity of the endothelial cells exposed to PMA-stimulated leukocytes.	Tetradecanoylphorbol Acetate	188-191	integrin subunit beta 2	Homo sapiens	48-52
7811990-5	1995	Based on densitometry of immune precipitates, CD43 levels were decreased 42% +/- 6% in neutrophils treated for 10 minutes with opsonized zymosan and decreased 70% +/- 3% in neutrophils treated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	231-234	sialophorin	Homo sapiens	46-50
7832755-4	1995	The depletion of PKC in these cell types after treatment with phorbol 12-myristate 13-acetate (PMA) resulted in inhibition of IFN-gamma-induced C2 production.	Tetradecanoylphorbol Acetate	62-93	interferon gamma	Homo sapiens	126-135
7832755-4	1995	The depletion of PKC in these cell types after treatment with phorbol 12-myristate 13-acetate (PMA) resulted in inhibition of IFN-gamma-induced C2 production.	Tetradecanoylphorbol Acetate	95-98	interferon gamma	Homo sapiens	126-135
7811990-6	1995	CD43 downregulation in response to opsonized zymosan, like PMA-induced CD43 downregulation, was insensitive to the serine protease inhibitor diisopropylfluorophosphate (DFP).	Tetradecanoylphorbol Acetate	59-62	sialophorin	Homo sapiens	0-4
7832781-11	1995	Although additional PKC subtypes appear to participate in the control of PtdCho synthesis in these cells, PMA-stimulated choline uptake in Swiss 3T3 fibroblasts is almost entirely dependent on the presence of PKC alpha.	Tetradecanoylphorbol Acetate	106-109	protein kinase C, alpha	Mus musculus	209-218
7811990-6	1995	CD43 downregulation in response to opsonized zymosan, like PMA-induced CD43 downregulation, was insensitive to the serine protease inhibitor diisopropylfluorophosphate (DFP).	Tetradecanoylphorbol Acetate	59-62	sialophorin	Homo sapiens	71-75
7818548-0	1995	A protein kinase C isozyme, nPKC epsilon, is involved in the activation of NF-kappa B by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat 3Y1 fibroblasts.	Tetradecanoylphorbol Acetate	89-125	protein kinase C, epsilon	Rattus norvegicus	28-40
7822278-4	1995	Chronic activation of protein kinase C by phorbol 12-myristate 13-acetate (PMA) and of adenylylcyclase by prostaglandin E1 (PGE1) resulted in heterologous down-regulation of thrombin receptor protein.	Tetradecanoylphorbol Acetate	42-73	coagulation factor II, thrombin	Homo sapiens	174-182
7822278-4	1995	Chronic activation of protein kinase C by phorbol 12-myristate 13-acetate (PMA) and of adenylylcyclase by prostaglandin E1 (PGE1) resulted in heterologous down-regulation of thrombin receptor protein.	Tetradecanoylphorbol Acetate	75-78	coagulation factor II, thrombin	Homo sapiens	174-182
7822278-5	1995	In contrast to thrombin, PMA and PGE1 reduced in parallel thrombin receptor mRNA levels to 51% and 24% of control, respectively, indicating that heterologous down-regulation of thrombin receptor protein is, at least in part, due to inhibition of receptor mRNA expression.	Tetradecanoylphorbol Acetate	25-28	coagulation factor II, thrombin	Homo sapiens	58-66
7822278-5	1995	In contrast to thrombin, PMA and PGE1 reduced in parallel thrombin receptor mRNA levels to 51% and 24% of control, respectively, indicating that heterologous down-regulation of thrombin receptor protein is, at least in part, due to inhibition of receptor mRNA expression.	Tetradecanoylphorbol Acetate	25-28	coagulation factor II, thrombin	Homo sapiens	58-66
7822278-7	1995	PMA-induced down-regulation was completely blocked by GF 109 203 X, an inhibitor of protein kinase C. However, the loss of thrombin receptor induced by thrombin was not prevented by GF 109 203 X, indicating that homologous regulation is not dependent on protein kinase C activation.	Tetradecanoylphorbol Acetate	0-3	coagulation factor II, thrombin	Homo sapiens	123-131
7822278-7	1995	PMA-induced down-regulation was completely blocked by GF 109 203 X, an inhibitor of protein kinase C. However, the loss of thrombin receptor induced by thrombin was not prevented by GF 109 203 X, indicating that homologous regulation is not dependent on protein kinase C activation.	Tetradecanoylphorbol Acetate	0-3	coagulation factor II, thrombin	Homo sapiens	152-160
7818548-6	1995	These results suggest that nPKC epsilon is specifically involved in the activation of NF-kappa B when cells are treated with TPA.	Tetradecanoylphorbol Acetate	125-128	protein kinase C, epsilon	Rattus norvegicus	27-39
7822270-8	1995	Furthermore, the p85 subunit of phosphatidylinositol-3-OH kinase (PI3 kinase) co-precipitated with the small isoform of the HGF receptor, and this association was dramatically inhibited by treatment with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	204-240	extracellular matrix protein 1	Mus musculus	17-20
7818548-0	1995	A protein kinase C isozyme, nPKC epsilon, is involved in the activation of NF-kappa B by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat 3Y1 fibroblasts.	Tetradecanoylphorbol Acetate	127-130	protein kinase C, epsilon	Rattus norvegicus	28-40
7545349-6	1995	Finally, LPS-stimulated Raji and PMA-stimulated THP-1 human cell lines showed increased levels of the cannabinoid receptor mRNA.	Tetradecanoylphorbol Acetate	33-36	GLI family zinc finger 2	Homo sapiens	48-53
7531948-5	1995	Butanol and PTX also significantly reduced the upregulation of CD11b/CD18 by f-methionyl-leucyl-phenylalanine (fMLP) and platelet-activating factor (PAF) but not by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	192-195	integrin subunit beta 2	Homo sapiens	69-73
8574146-3	1995	In contrast, anti-CD3 with PMA gives a more vigorous IL-2 response than with anti-CD28, ie, 37.3 ng/ml compared to 12.3 ng/ml for controls and 28.5 ng/ml versus 15.1 ng/ml for HIV+ cells, respectively.	Tetradecanoylphorbol Acetate	27-30	interleukin 2	Homo sapiens	53-57
7733619-7	1995	The fraction of Mac-1 positive cells increased to 90.5% (TPA), 80.6% (RA), 84.5% (SB) and decreased to 52.7% (DMSO).	Tetradecanoylphorbol Acetate	57-60	integrin alpha M	Mus musculus	16-21
8746780-3	1995	We found that a line of cultured human mesothelial cells (MeT5A) expressed specific and saturable binding sites for uPA that increased on stimulation with PMA.	Tetradecanoylphorbol Acetate	155-158	plasminogen activator, urokinase	Homo sapiens	116-119
7661690-2	1995	Treatment of phorbol 12-myristate 13-acetate (PMA) differentiated monocyte-like cells THP-1 or human fibroblasts MRC-5 with lectins specific for N-acetylneuraminic acid (NeuAc) blocked infection with HCMV.	Tetradecanoylphorbol Acetate	13-44	GLI family zinc finger 2	Homo sapiens	86-91
7661690-2	1995	Treatment of phorbol 12-myristate 13-acetate (PMA) differentiated monocyte-like cells THP-1 or human fibroblasts MRC-5 with lectins specific for N-acetylneuraminic acid (NeuAc) blocked infection with HCMV.	Tetradecanoylphorbol Acetate	46-49	GLI family zinc finger 2	Homo sapiens	86-91
8534863-4	1995	VEGF expression can be induced in various cell types by a number of stimuli including hypoxia, differentiation, growth factors and tumor promoters of the phorbol ester class, such as TPA.	Tetradecanoylphorbol Acetate	183-186	vascular endothelial growth factor A	Homo sapiens	0-4
7895307-0	1995	N-Alkylphthalimides: structural requirement of thalidomidal action on 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor alpha production by human leukemia HL-60 cells.	Tetradecanoylphorbol Acetate	70-106	tumor necrosis factor	Homo sapiens	115-142
7895307-2	1995	All the compounds prepared except N-n-butylphthalimide showed thalidomidal activity on 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor (TNF)-alpha production by human leukemia HL-60 cells.	Tetradecanoylphorbol Acetate	87-123	tumor necrosis factor	Homo sapiens	155-165
7774103-4	1995	By contrast, PMA-induced production of IL-1 beta was impaired in RA patients and was preceded by the disregulated expression of c-Fos and c-Jun proteins when compared with healthy donors.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 beta	Homo sapiens	39-48
8574146-1	1995	We find that purified CD4+ T cells from 30 HIV+ individuals have a suppressed Interleukin-4 (IL-4) production compared to normal controls regardless of activator (anti-CD3 or Con A) or co-activator [phorbol ester (PMA or anti-CD28)], generally by 2-4 fold.	Tetradecanoylphorbol Acetate	214-217	CD4 molecule	Homo sapiens	22-25
7843222-8	1995	PMA-induced PKC activation for a 1-h period resulted in a translocation of PKC delta from resting cytoplasmic/nuclear staining to a cytoplasmic aggregate.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	12-15
8930020-5	1995	Here, we demonstrate that both hypoxia and TPA induce stabilization of VEGF mRNA, that stabilization by hypoxia is rapidly reversible upon reexposure to normoxia, and that tumor cell lines exhibiting constitutive overexpression of VEGF also exhibit constitutive stabilization of VEGF transcripts.	Tetradecanoylphorbol Acetate	43-46	vascular endothelial growth factor A	Homo sapiens	71-75
8930020-6	1995	Stabilized VEGF transcripts in tumor cells are refractile or nearly refractile toward further stabilization by TPA or hypoxia, respectively.	Tetradecanoylphorbol Acetate	111-114	vascular endothelial growth factor A	Homo sapiens	11-15
7768965-1	1995	As a part of a series of investigations on the functions of TIS21 and TIS1 genes, we measured in vivo 12-O-tetradecanoylphorbol-13-acetate (TPA) inducibility of primary response genes (TIS21, TIS8 and TIS1) in the Balb/c mice and the changes of TIS gene expression in thymic carcinoma tissues and A549 and NCIH69 human lung cancer cell lines.	Tetradecanoylphorbol Acetate	102-138	BTG anti-proliferation factor 2	Mus musculus	60-65
7607614-5	1995	To identify the signalling pathway involved, we used; (a) monoclonal antibody MA-5, directed against the alpha-subunit of the insulin receptor, that partially mimics insulin without activating tyrosine kinase; (b) H7, an inhibitor of PKC involved in O2- production in PMNLs, and (c) phorbol myristate acetate (PMA) that binds and stimulates PKC.	Tetradecanoylphorbol Acetate	283-308	insulin	Homo sapiens	126-133
7607614-5	1995	To identify the signalling pathway involved, we used; (a) monoclonal antibody MA-5, directed against the alpha-subunit of the insulin receptor, that partially mimics insulin without activating tyrosine kinase; (b) H7, an inhibitor of PKC involved in O2- production in PMNLs, and (c) phorbol myristate acetate (PMA) that binds and stimulates PKC.	Tetradecanoylphorbol Acetate	310-313	insulin	Homo sapiens	126-133
7768965-1	1995	As a part of a series of investigations on the functions of TIS21 and TIS1 genes, we measured in vivo 12-O-tetradecanoylphorbol-13-acetate (TPA) inducibility of primary response genes (TIS21, TIS8 and TIS1) in the Balb/c mice and the changes of TIS gene expression in thymic carcinoma tissues and A549 and NCIH69 human lung cancer cell lines.	Tetradecanoylphorbol Acetate	102-138	BTG anti-proliferation factor 2	Mus musculus	185-190
7797600-7	1995	Furthermore, a positive influence of phorbol 12-myristate 13-acetate (PMA) on the ability of U 937 cells to produce TNF following a treatment with HPC or HPC-MLV could be observed.	Tetradecanoylphorbol Acetate	37-68	tumor necrosis factor	Homo sapiens	116-119
7797600-7	1995	Furthermore, a positive influence of phorbol 12-myristate 13-acetate (PMA) on the ability of U 937 cells to produce TNF following a treatment with HPC or HPC-MLV could be observed.	Tetradecanoylphorbol Acetate	70-73	tumor necrosis factor	Homo sapiens	116-119
7768965-1	1995	As a part of a series of investigations on the functions of TIS21 and TIS1 genes, we measured in vivo 12-O-tetradecanoylphorbol-13-acetate (TPA) inducibility of primary response genes (TIS21, TIS8 and TIS1) in the Balb/c mice and the changes of TIS gene expression in thymic carcinoma tissues and A549 and NCIH69 human lung cancer cell lines.	Tetradecanoylphorbol Acetate	140-143	BTG anti-proliferation factor 2	Mus musculus	60-65
7768965-1	1995	As a part of a series of investigations on the functions of TIS21 and TIS1 genes, we measured in vivo 12-O-tetradecanoylphorbol-13-acetate (TPA) inducibility of primary response genes (TIS21, TIS8 and TIS1) in the Balb/c mice and the changes of TIS gene expression in thymic carcinoma tissues and A549 and NCIH69 human lung cancer cell lines.	Tetradecanoylphorbol Acetate	140-143	BTG anti-proliferation factor 2	Mus musculus	185-190
7768965-2	1995	In vivo induction of the TIS genes (TIS21, -8 and -1) by intraperitoneal injection of TPA was dramatic only at the needle contact site, i.e. in the abdominal muscle, not in the thigh muscle.	Tetradecanoylphorbol Acetate	86-89	programmed cell death 4	Mus musculus	25-28
7768965-7	1995	We also measured the induction of TIS genes by TPA and/or cycloheximide in Raw264.7 mouse macrophage cells and U937 human histiocytic lymphoma cells.	Tetradecanoylphorbol Acetate	47-50	programmed cell death 4	Mus musculus	34-37
8705253-6	1995	Lungs of control animals exposed to PMA developed an increase in lung weight and lipid peroxidation as well as a decrease in lung angiotensin converting enzyme (ACE) and alkaline phosphatase (AKP) activities.	Tetradecanoylphorbol Acetate	36-39	angiotensin I converting enzyme	Rattus norvegicus	130-159
7814617-7	1995	A threefold increase of beta ARK1 immunoreactivity was found in MNL exposed to PHA for 72 h. Persistent activation of protein kinase C (PKC) by 10 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) was able to increase beta ARK activity to the same extent as PHA, suggesting a PKC-mediated mechanism.	Tetradecanoylphorbol Acetate	150-186	G protein-coupled receptor kinase 2	Homo sapiens	24-33
7814617-7	1995	A threefold increase of beta ARK1 immunoreactivity was found in MNL exposed to PHA for 72 h. Persistent activation of protein kinase C (PKC) by 10 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) was able to increase beta ARK activity to the same extent as PHA, suggesting a PKC-mediated mechanism.	Tetradecanoylphorbol Acetate	188-191	G protein-coupled receptor kinase 2	Homo sapiens	24-33
7812167-10	1995	The spontaneous production of IFN-gamma in the cultures did not differ between the groups, but upon stimulation with phorbol myristate acetate, the atopic dermatitis group demonstrated significantly lower IFN-gamma levels compared to the two other groups.	Tetradecanoylphorbol Acetate	117-142	interferon gamma	Homo sapiens	205-214
8705253-6	1995	Lungs of control animals exposed to PMA developed an increase in lung weight and lipid peroxidation as well as a decrease in lung angiotensin converting enzyme (ACE) and alkaline phosphatase (AKP) activities.	Tetradecanoylphorbol Acetate	36-39	angiotensin I converting enzyme	Rattus norvegicus	161-164
7983701-7	1995	Selected transfected clones produced low levels of IFN A (IFNA) constitutively, and their abilities to express interleukin-2 and interleukin-2 receptor upon stimulation with phytohemagglutinin and phorbol myristate acetate were retained.	Tetradecanoylphorbol Acetate	197-222	interleukin 2	Homo sapiens	111-124
7983701-7	1995	Selected transfected clones produced low levels of IFN A (IFNA) constitutively, and their abilities to express interleukin-2 and interleukin-2 receptor upon stimulation with phytohemagglutinin and phorbol myristate acetate were retained.	Tetradecanoylphorbol Acetate	197-222	interleukin 2	Homo sapiens	129-142
7475908-5	1995	During the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced differentiation process, the contents of Gi2 alpha and Gi3 alpha increased, whereas the protein levels of Gz alpha, Gs alpha, G11 alpha and G12 alpha were observed to hardly change.	Tetradecanoylphorbol Acetate	11-48	GNAS complex locus	Homo sapiens	179-187
7869830-2	1995	THP-1 cells were exposed to TPA for 48 or 96 hours to induce differentiation.	Tetradecanoylphorbol Acetate	28-31	GLI family zinc finger 2	Homo sapiens	0-5
7475908-5	1995	During the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced differentiation process, the contents of Gi2 alpha and Gi3 alpha increased, whereas the protein levels of Gz alpha, Gs alpha, G11 alpha and G12 alpha were observed to hardly change.	Tetradecanoylphorbol Acetate	50-53	GNAS complex locus	Homo sapiens	179-187
7475908-7	1995	For the expression of Gi2 alpha and beta subunits, chronic TPA-treatment was required although Rac2, a low M(r) GTP-binding protein, was expressed abundantly by only 30 min-TPA-treatment followed by 3 day-culture.	Tetradecanoylphorbol Acetate	173-176	Rac family small GTPase 2	Homo sapiens	95-99
7770008-5	1995	After 24 h the protein kinase C (PKC) activator phorbol ester (PMA) increases the insulin binding to a similar degree as does the insulin imprinting itself.	Tetradecanoylphorbol Acetate	63-66	insulin	Homo sapiens	82-89
7770008-6	1995	There was only one dose of the three tested in which PMA inhibited the development of insulin imprinting, whereas the PKC inhibitor reduced insulin binding after 24 h, but could not inhibit insulin imprinting.	Tetradecanoylphorbol Acetate	53-56	insulin	Homo sapiens	86-93
8552204-0	1995	Phorbol ester (TPA)-induced differential modulation of cell surface antigens in human pluripotential leukemia (K-562) cell line: effects of protein kinase inhibitors with broad- and PKC selective inhibitory activity.	Tetradecanoylphorbol Acetate	15-18	proline rich transmembrane protein 2	Homo sapiens	182-185
8560094-3	1995	We measured its effect on the production of superoxide anion (O2-) by polymorphonuclear leukocytes (PMN) that was induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) or by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	178-203	formyl peptide receptor 1	Homo sapiens	166-170
8552199-4	1995	TPA treatment induced hairy cell leukemia (HCL) characteristics, given by the membrane CD22 and CD25 expression and TRAP positivity in the majority of the cases tested.	Tetradecanoylphorbol Acetate	0-3	CD22 molecule	Homo sapiens	87-91
8552199-7	1995	Furthermore, we originally demonstrated that the CD22, present in the cell membrane after TPA, could be detected in the majority of unaffected B-CLL cells in their cytoplasm.	Tetradecanoylphorbol Acetate	90-93	CD22 molecule	Homo sapiens	49-53
8747598-1	1995	Sensitivity to cell killing by tumor necrosis factor (TNF)-alpha was seen in the JB6-derived transformed mouse RT101 cell variants previously described as resistant to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced killing, while the TPA-sensitive variants were resistant to killing by TNF-alpha.	Tetradecanoylphorbol Acetate	168-204	tumor necrosis factor	Mus musculus	31-64
8747598-1	1995	Sensitivity to cell killing by tumor necrosis factor (TNF)-alpha was seen in the JB6-derived transformed mouse RT101 cell variants previously described as resistant to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced killing, while the TPA-sensitive variants were resistant to killing by TNF-alpha.	Tetradecanoylphorbol Acetate	206-209	tumor necrosis factor	Mus musculus	31-64
8747598-1	1995	Sensitivity to cell killing by tumor necrosis factor (TNF)-alpha was seen in the JB6-derived transformed mouse RT101 cell variants previously described as resistant to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced killing, while the TPA-sensitive variants were resistant to killing by TNF-alpha.	Tetradecanoylphorbol Acetate	238-241	tumor necrosis factor	Mus musculus	31-64
7784702-0	1995	Differing kinase activity of the c-yes and c-src gene proteins in TPA-induced megakaryocytic differentiation of T-33 and K562 cell lines.	Tetradecanoylphorbol Acetate	66-69	YES proto-oncogene 1, Src family tyrosine kinase	Homo sapiens	33-38
7784702-0	1995	Differing kinase activity of the c-yes and c-src gene proteins in TPA-induced megakaryocytic differentiation of T-33 and K562 cell lines.	Tetradecanoylphorbol Acetate	66-69	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-48
7784702-1	1995	We examined the protein kinase (PK) activity of the c-yes and c-src gene proteins (c-YES, c-SRC) at an early phase of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced megakaryocytic differentiation of T-33 and K562 cells with use of immunoprecipitation and in vitro kinase assay.	Tetradecanoylphorbol Acetate	118-155	YES proto-oncogene 1, Src family tyrosine kinase	Homo sapiens	52-57
7784702-1	1995	We examined the protein kinase (PK) activity of the c-yes and c-src gene proteins (c-YES, c-SRC) at an early phase of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced megakaryocytic differentiation of T-33 and K562 cells with use of immunoprecipitation and in vitro kinase assay.	Tetradecanoylphorbol Acetate	118-155	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	62-67
7784702-1	1995	We examined the protein kinase (PK) activity of the c-yes and c-src gene proteins (c-YES, c-SRC) at an early phase of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced megakaryocytic differentiation of T-33 and K562 cells with use of immunoprecipitation and in vitro kinase assay.	Tetradecanoylphorbol Acetate	118-155	YES proto-oncogene 1, Src family tyrosine kinase	Homo sapiens	83-88
7784702-1	1995	We examined the protein kinase (PK) activity of the c-yes and c-src gene proteins (c-YES, c-SRC) at an early phase of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced megakaryocytic differentiation of T-33 and K562 cells with use of immunoprecipitation and in vitro kinase assay.	Tetradecanoylphorbol Acetate	118-155	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-95
7784702-1	1995	We examined the protein kinase (PK) activity of the c-yes and c-src gene proteins (c-YES, c-SRC) at an early phase of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced megakaryocytic differentiation of T-33 and K562 cells with use of immunoprecipitation and in vitro kinase assay.	Tetradecanoylphorbol Acetate	157-160	YES proto-oncogene 1, Src family tyrosine kinase	Homo sapiens	52-57
7784702-1	1995	We examined the protein kinase (PK) activity of the c-yes and c-src gene proteins (c-YES, c-SRC) at an early phase of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced megakaryocytic differentiation of T-33 and K562 cells with use of immunoprecipitation and in vitro kinase assay.	Tetradecanoylphorbol Acetate	157-160	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	62-67
7784702-1	1995	We examined the protein kinase (PK) activity of the c-yes and c-src gene proteins (c-YES, c-SRC) at an early phase of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced megakaryocytic differentiation of T-33 and K562 cells with use of immunoprecipitation and in vitro kinase assay.	Tetradecanoylphorbol Acetate	157-160	YES proto-oncogene 1, Src family tyrosine kinase	Homo sapiens	83-88
8560094-3	1995	We measured its effect on the production of superoxide anion (O2-) by polymorphonuclear leukocytes (PMN) that was induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) or by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	205-208	formyl peptide receptor 1	Homo sapiens	166-170
7784702-1	1995	We examined the protein kinase (PK) activity of the c-yes and c-src gene proteins (c-YES, c-SRC) at an early phase of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced megakaryocytic differentiation of T-33 and K562 cells with use of immunoprecipitation and in vitro kinase assay.	Tetradecanoylphorbol Acetate	157-160	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-95
7784702-2	1995	We found that c-SRC PK activity of TPA-treated T-33 and K562 cell lines had been enhanced compared with the untreated ones, but in contrast, no enhancement of c-YES PK activity by the TPA treatment was observed in these cell lines.	Tetradecanoylphorbol Acetate	35-38	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-19
7803515-3	1994	We then used these methods to examine the effects of carbamylcholine, a cholinergic agonist that increases cellular calcium and diacylglycerol concentrations, and PMA, a phorbol ester that activates PKC, on the subcellular distribution of these isoforms.	Tetradecanoylphorbol Acetate	163-166	proline rich transmembrane protein 2	Homo sapiens	199-202
7784702-3	1995	We also examined PK activity in TPA-induced monocytic differentiation of U937 monoblastic cells that exhibited no megakaryocytic markers and found that both the c-YES and c-SRC PK activity was enhanced by the TPA treatment.	Tetradecanoylphorbol Acetate	32-35	YES proto-oncogene 1, Src family tyrosine kinase	Homo sapiens	161-166
7784702-3	1995	We also examined PK activity in TPA-induced monocytic differentiation of U937 monoblastic cells that exhibited no megakaryocytic markers and found that both the c-YES and c-SRC PK activity was enhanced by the TPA treatment.	Tetradecanoylphorbol Acetate	32-35	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	171-176
7784702-3	1995	We also examined PK activity in TPA-induced monocytic differentiation of U937 monoblastic cells that exhibited no megakaryocytic markers and found that both the c-YES and c-SRC PK activity was enhanced by the TPA treatment.	Tetradecanoylphorbol Acetate	209-212	YES proto-oncogene 1, Src family tyrosine kinase	Homo sapiens	161-166
7784702-3	1995	We also examined PK activity in TPA-induced monocytic differentiation of U937 monoblastic cells that exhibited no megakaryocytic markers and found that both the c-YES and c-SRC PK activity was enhanced by the TPA treatment.	Tetradecanoylphorbol Acetate	209-212	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	171-176
7784702-4	1995	Our data suggest that c-YES and c-SRC play different and unique roles in TPA-induced megakaryocytic differentiation in T-33 and K562 cells.	Tetradecanoylphorbol Acetate	73-76	YES proto-oncogene 1, Src family tyrosine kinase	Homo sapiens	22-27
7784702-4	1995	Our data suggest that c-YES and c-SRC play different and unique roles in TPA-induced megakaryocytic differentiation in T-33 and K562 cells.	Tetradecanoylphorbol Acetate	73-76	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	32-37
7604388-6	1995	In BMP-4 transgenic mice, TPA treatment induced the expression of the BMP-4 transgene in interfollicular epidermis but only minimal epidermal thickening, hyperproliferation, and inflammation were noted after the initial dose of TPA.	Tetradecanoylphorbol Acetate	26-29	bone morphogenetic protein 4	Mus musculus	3-8
7604388-6	1995	In BMP-4 transgenic mice, TPA treatment induced the expression of the BMP-4 transgene in interfollicular epidermis but only minimal epidermal thickening, hyperproliferation, and inflammation were noted after the initial dose of TPA.	Tetradecanoylphorbol Acetate	26-29	bone morphogenetic protein 4	Mus musculus	70-75
7604388-9	1995	In conclusion, we have shown that the TPA induced expression of the BMP-4 transgene blocks proliferation and inflammation in skin, steps that are critical to the subsequent formation of papillomas and SCCs and we characterized an inducible promotersystem which expresses polypeptides in interfollicular epidermis after exogenous stimulation.	Tetradecanoylphorbol Acetate	38-41	bone morphogenetic protein 4	Mus musculus	68-73
7719248-6	1995	Phorbol-12-myristate-13-acetate increased the expression of both CD41a and CD61 antigens.	Tetradecanoylphorbol Acetate	0-31	integrin subunit beta 3	Homo sapiens	75-79
7811292-1	1994	N-2,6-Dialkylphenylphthalimides were found to be strong enhancers of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor necrosis factor (TNF)-alpha production by human leukemia cell line HL-60.	Tetradecanoylphorbol Acetate	69-105	tumor necrosis factor	Homo sapiens	143-153
7811292-1	1994	N-2,6-Dialkylphenylphthalimides were found to be strong enhancers of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor necrosis factor (TNF)-alpha production by human leukemia cell line HL-60.	Tetradecanoylphorbol Acetate	107-110	tumor necrosis factor	Homo sapiens	143-153
7803515-4	1994	Carbamylcholine and PMA caused an increase in membrane-associated alpha PKC, but did not alter the subcellular distribution of zeta PKC.	Tetradecanoylphorbol Acetate	20-23	proline rich transmembrane protein 2	Homo sapiens	72-75
7527398-2	1994	In cell-free extracts made from gingival fibroblasts treated with platelet-derived growth factor or HepG2 hepatoma cells stimulated with phorbol myristate acetate, MBP and Thr669 kinase were both elevated 4-fold, and ERK1 and ERK2 were tyrosine-phosphorylated.	Tetradecanoylphorbol Acetate	137-162	mitogen-activated protein kinase 3	Homo sapiens	217-221
7527398-2	1994	In cell-free extracts made from gingival fibroblasts treated with platelet-derived growth factor or HepG2 hepatoma cells stimulated with phorbol myristate acetate, MBP and Thr669 kinase were both elevated 4-fold, and ERK1 and ERK2 were tyrosine-phosphorylated.	Tetradecanoylphorbol Acetate	137-162	mitogen-activated protein kinase 1	Homo sapiens	226-230
7716283-1	1994	Vasoactive intestinal peptide (VIP) primed the respiratory burst of human neutrophils induced by phorbol myristate acetate (PMA) and by the chemotactic peptide N-formyl-Met-Leu-Phe (fMLP).	Tetradecanoylphorbol Acetate	97-122	vasoactive intestinal peptide	Homo sapiens	31-34
7805853-3	1994	cPKC-alpha, nPKC-epsilon or aPKC-zeta expression plasmids each stimulated ANF-promoter activity and expression of a reporter gene under the control of a 12-O-tetradecanoylphorbol 13-acetate-response element (TRE).	Tetradecanoylphorbol Acetate	153-189	protein kinase C, epsilon	Rattus norvegicus	12-24
7802630-1	1994	v-Src activates gene expression mediated by serum response elements (SREs) and TPA response elements (TREs).	Tetradecanoylphorbol Acetate	79-82	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	2-5
7816604-2	1994	In the experiments reported here the transcriptional promoter for an early enzyme of the pathway, 3-hydroxy-3-methylglutaryl coenzyme A synthase, is shown to be activated by the growth stimulatory agent tetraphorbol acetate (TPA).	Tetradecanoylphorbol Acetate	225-228	Coenzyme A synthase	Homo sapiens	125-144
7811304-6	1994	When mitoxantrone was incubated with neutrophils that had been stimulated with phorbol myristate acetate, it was oxidized by an MPO-dependent mechanism.	Tetradecanoylphorbol Acetate	79-104	myeloperoxidase	Homo sapiens	128-131
7802642-3	1994	Functional analysis of the promoter 1 with a transient expression assay using chloramphenicol acetyltransferase (CAT) gene as a reporter showed that both PAF and TPA activated the promoter 1 but not the deleted promoter lacking the three consensus binding sites for NF-kappa B located from -571 bp to -459 bp.	Tetradecanoylphorbol Acetate	162-165	nuclear factor kappa B subunit 1	Homo sapiens	266-276
7716283-1	1994	Vasoactive intestinal peptide (VIP) primed the respiratory burst of human neutrophils induced by phorbol myristate acetate (PMA) and by the chemotactic peptide N-formyl-Met-Leu-Phe (fMLP).	Tetradecanoylphorbol Acetate	124-127	vasoactive intestinal peptide	Homo sapiens	31-34
7982907-7	1994	We showed that CD28 signaling, distinct from other stimuli such as phorbol 12-myristate 13-acetate, IL-1, and tumor necrosis factor-alpha, caused a sustained down-regulation of the inhibitor I kappa B alpha in Jurkat T cells.	Tetradecanoylphorbol Acetate	67-98	NFKB inhibitor alpha	Homo sapiens	191-206
7983040-4	1994	Addition of the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted also in a rapid (30 min) and selective increase in PKC beta, but not PKC alpha, mRNA levels.	Tetradecanoylphorbol Acetate	30-66	protein kinase C, alpha	Mus musculus	151-160
7983040-4	1994	Addition of the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted also in a rapid (30 min) and selective increase in PKC beta, but not PKC alpha, mRNA levels.	Tetradecanoylphorbol Acetate	68-71	protein kinase C, alpha	Mus musculus	151-160
7982907-11	1994	In contrast, the phorbol 12-myristate 13-acetate/ionomycin-mediated down-regulation of I kappa B alpha was prevented by CsA but not by rapamycin.	Tetradecanoylphorbol Acetate	17-48	NFKB inhibitor alpha	Homo sapiens	87-102
7982967-8	1994	The direct PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced phosphorylation of Cx43 that was completely blocked by the protein kinase C inhibitor, staurosporine.	Tetradecanoylphorbol Acetate	26-62	gap junction protein, alpha 1	Rattus norvegicus	97-101
7982981-0	1994	In vitro study of functional involvement of Sp1, NF-kappa B/Rel, and AP1 in phorbol 12-myristate 13-acetate-mediated HIV-1 long terminal repeat activation.	Tetradecanoylphorbol Acetate	76-107	nuclear factor kappa B subunit 1	Homo sapiens	49-59
7982908-2	1994	In this report, we further studied the phosphorylation involved in NF-kappa B activation in Jurkat T cells responding to phorbol 12-myristate 13-acetate and phytohemagglutinin.	Tetradecanoylphorbol Acetate	121-152	nuclear factor kappa B subunit 1	Homo sapiens	67-77
7982981-0	1994	In vitro study of functional involvement of Sp1, NF-kappa B/Rel, and AP1 in phorbol 12-myristate 13-acetate-mediated HIV-1 long terminal repeat activation.	Tetradecanoylphorbol Acetate	76-107	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-72
7982967-8	1994	The direct PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced phosphorylation of Cx43 that was completely blocked by the protein kinase C inhibitor, staurosporine.	Tetradecanoylphorbol Acetate	64-67	gap junction protein, alpha 1	Rattus norvegicus	97-101
7982981-1	1994	We examined the cooperative activity between the Sp1 and NF-kappa B/Rel sites of the human immunodeficiency virus type 1 long terminal repeat in response to phorbol 12-myristate 13-acetate (PMA) stimulation in an in vitro transcription assay.	Tetradecanoylphorbol Acetate	157-188	nuclear factor kappa B subunit 1	Homo sapiens	57-67
7982915-1	1994	Treatment of cells with interferon (IFN)-gamma or phorbol myristate acetate (PMA) induces up-regulation of the level of intercellular adhesion molecule-1 (ICAM-1; CD54) mRNA by stabilization of an otherwise labile mRNA.	Tetradecanoylphorbol Acetate	77-80	interferon gamma	Mus musculus	24-46
7982981-1	1994	We examined the cooperative activity between the Sp1 and NF-kappa B/Rel sites of the human immunodeficiency virus type 1 long terminal repeat in response to phorbol 12-myristate 13-acetate (PMA) stimulation in an in vitro transcription assay.	Tetradecanoylphorbol Acetate	190-193	nuclear factor kappa B subunit 1	Homo sapiens	57-67
7983381-5	1994	Jurkat T lymphocytes were stimulated with ionomycin + phorbol myristate acetate to produce interleukin-2 (IL-2) mRNA in vitro overnight.	Tetradecanoylphorbol Acetate	54-79	interleukin 2	Homo sapiens	91-104
7983381-5	1994	Jurkat T lymphocytes were stimulated with ionomycin + phorbol myristate acetate to produce interleukin-2 (IL-2) mRNA in vitro overnight.	Tetradecanoylphorbol Acetate	54-79	interleukin 2	Homo sapiens	106-110
7949125-10	1994	Basic fibroblast growth factor (bFGF) and phorbol myristate acetate (PMA) showed a more prolonged effect increasing u-PAR mRNA levels 8 +/- 2.0-fold and 12.3 +/- 2.5-fold, respectively, within 6 hours but remaining 5 to 10-fold elevated at 48 hours.	Tetradecanoylphorbol Acetate	42-67	plasminogen activator, urokinase receptor	Bos taurus	116-121
7810625-5	1994	The protein kinase C agonist phorbol 12-myristate 13-acetate (PMA) stimulated basal renin release and potentiated the effect of ET-1 on renin release.	Tetradecanoylphorbol Acetate	29-60	renin	Homo sapiens	84-89
7810625-5	1994	The protein kinase C agonist phorbol 12-myristate 13-acetate (PMA) stimulated basal renin release and potentiated the effect of ET-1 on renin release.	Tetradecanoylphorbol Acetate	29-60	endothelin 1	Homo sapiens	128-132
7810625-5	1994	The protein kinase C agonist phorbol 12-myristate 13-acetate (PMA) stimulated basal renin release and potentiated the effect of ET-1 on renin release.	Tetradecanoylphorbol Acetate	29-60	renin	Homo sapiens	136-141
7810625-5	1994	The protein kinase C agonist phorbol 12-myristate 13-acetate (PMA) stimulated basal renin release and potentiated the effect of ET-1 on renin release.	Tetradecanoylphorbol Acetate	62-65	renin	Homo sapiens	84-89
7810625-5	1994	The protein kinase C agonist phorbol 12-myristate 13-acetate (PMA) stimulated basal renin release and potentiated the effect of ET-1 on renin release.	Tetradecanoylphorbol Acetate	62-65	endothelin 1	Homo sapiens	128-132
7810625-5	1994	The protein kinase C agonist phorbol 12-myristate 13-acetate (PMA) stimulated basal renin release and potentiated the effect of ET-1 on renin release.	Tetradecanoylphorbol Acetate	62-65	renin	Homo sapiens	136-141
7810625-6	1994	However, PMA inhibited basal PRL release and also enhanced the inhibitory effect of ET-1.	Tetradecanoylphorbol Acetate	9-12	prolactin	Homo sapiens	29-32
7810625-6	1994	However, PMA inhibited basal PRL release and also enhanced the inhibitory effect of ET-1.	Tetradecanoylphorbol Acetate	9-12	endothelin 1	Homo sapiens	84-88
7949125-10	1994	Basic fibroblast growth factor (bFGF) and phorbol myristate acetate (PMA) showed a more prolonged effect increasing u-PAR mRNA levels 8 +/- 2.0-fold and 12.3 +/- 2.5-fold, respectively, within 6 hours but remaining 5 to 10-fold elevated at 48 hours.	Tetradecanoylphorbol Acetate	69-72	plasminogen activator, urokinase receptor	Bos taurus	116-121
7995178-3	1994	A PKC inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), significantly reduced the pepsinogen secretion by carbachol or TPA, but not by forskolin or ionomycin, and did not affect the basal secretion and the [Ca2+]i elevated by carbachol or ionomycin.	Tetradecanoylphorbol Acetate	133-136	proline rich transmembrane protein 2	Homo sapiens	2-5
8001237-1	1994	The present study has examined changes in activities and levels of four protein kinase C (PKC) isozymes (PKC alpha, PKC beta, PKC gamma and PKC delta) detectable in mouse epidermal preparations following both single and multiple treatments with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	245-281	protein kinase C, alpha	Mus musculus	90-93
8001237-1	1994	The present study has examined changes in activities and levels of four protein kinase C (PKC) isozymes (PKC alpha, PKC beta, PKC gamma and PKC delta) detectable in mouse epidermal preparations following both single and multiple treatments with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	283-286	protein kinase C, alpha	Mus musculus	90-93
8001237-6	1994	Significant reductions in all four detectable PKC isozyme activities in both particulate and cytosol fractions were observed 48 h after a single treatment with TPA, although particulate PKC alpha activity appeared to be less affected at this point in time compared to the other PKC isozymes.	Tetradecanoylphorbol Acetate	160-163	protein kinase C, alpha	Mus musculus	46-49
8001237-6	1994	Significant reductions in all four detectable PKC isozyme activities in both particulate and cytosol fractions were observed 48 h after a single treatment with TPA, although particulate PKC alpha activity appeared to be less affected at this point in time compared to the other PKC isozymes.	Tetradecanoylphorbol Acetate	160-163	protein kinase C, alpha	Mus musculus	186-195
8001237-6	1994	Significant reductions in all four detectable PKC isozyme activities in both particulate and cytosol fractions were observed 48 h after a single treatment with TPA, although particulate PKC alpha activity appeared to be less affected at this point in time compared to the other PKC isozymes.	Tetradecanoylphorbol Acetate	160-163	protein kinase C, alpha	Mus musculus	186-189
8001237-7	1994	Immunoblotting analyses of PKC isozyme protein levels after TPA treatment followed the changes in activity for cytosolic PKC alpha, PKC beta and PKC gamma.	Tetradecanoylphorbol Acetate	60-63	protein kinase C, alpha	Mus musculus	27-30
8001237-7	1994	Immunoblotting analyses of PKC isozyme protein levels after TPA treatment followed the changes in activity for cytosolic PKC alpha, PKC beta and PKC gamma.	Tetradecanoylphorbol Acetate	60-63	protein kinase C, alpha	Mus musculus	121-130
8001237-9	1994	Multiple topical treatments (twice-weekly for 2 weeks) with TPA produced a pattern of loss followed by only partial recovery of total PKC activity.	Tetradecanoylphorbol Acetate	60-63	protein kinase C, alpha	Mus musculus	134-137
8001237-10	1994	Furthermore, all four PKC isozyme activities examined by hydroxylapatite (HA) chromatography were significantly reduced, including PKC alpha, after four applications of TPA.	Tetradecanoylphorbol Acetate	169-172	protein kinase C, alpha	Mus musculus	22-25
8001237-10	1994	Furthermore, all four PKC isozyme activities examined by hydroxylapatite (HA) chromatography were significantly reduced, including PKC alpha, after four applications of TPA.	Tetradecanoylphorbol Acetate	169-172	protein kinase C, alpha	Mus musculus	131-140
7994760-9	1994	In addition, phorbol 12-myristate 13-acetate and phorbol 12, 13-dibutyrate also induced growth inhibition followed by apoptotic cell death in MBC-1 cells.	Tetradecanoylphorbol Acetate	13-44	coiled-coil domain containing 112	Homo sapiens	142-147
7720732-4	1994	U937 cells and other human myeloid leukemia cell lines (HL-60, THP-1) can be induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to differentiate along the monocytic pathway.	Tetradecanoylphorbol Acetate	106-142	GLI family zinc finger 2	Homo sapiens	63-68
8001557-4	1994	Hydrogen peroxide prevented phorbol-myristate-acetate-stimulated AP-1 binding to DNA but stimulated it if protein kinase C was down-regulated or inhibited.	Tetradecanoylphorbol Acetate	28-53	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-69
7720732-4	1994	U937 cells and other human myeloid leukemia cell lines (HL-60, THP-1) can be induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to differentiate along the monocytic pathway.	Tetradecanoylphorbol Acetate	144-147	GLI family zinc finger 2	Homo sapiens	63-68
7720732-6	1994	Thus, the presence of leukocyte integrins including CD11 and CD18, which are significantly induced during TPA-induced differentiation of HL-60, U937 and THP-1 cells, remained nearly unchanged at low levels in both TUR and TPA-treated TUR cells.	Tetradecanoylphorbol Acetate	106-109	integrin subunit beta 2	Homo sapiens	61-65
7720732-6	1994	Thus, the presence of leukocyte integrins including CD11 and CD18, which are significantly induced during TPA-induced differentiation of HL-60, U937 and THP-1 cells, remained nearly unchanged at low levels in both TUR and TPA-treated TUR cells.	Tetradecanoylphorbol Acetate	106-109	GLI family zinc finger 2	Homo sapiens	153-158
7720732-6	1994	Thus, the presence of leukocyte integrins including CD11 and CD18, which are significantly induced during TPA-induced differentiation of HL-60, U937 and THP-1 cells, remained nearly unchanged at low levels in both TUR and TPA-treated TUR cells.	Tetradecanoylphorbol Acetate	222-225	integrin subunit beta 2	Homo sapiens	61-65
7804449-8	1994	The PTH-induced increase in Pi uptake was abolished almost completely by pretreating cells with PKC inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride (H-7) (50 mumol/l) or staurosporin (10 and 50 nmol/l), and by down-regulating PKC with a prolonged TPA treatment.	Tetradecanoylphorbol Acetate	274-277	parathyroid hormone	Rattus norvegicus	4-7
7988415-6	1994	We previously demonstrated decreased responsiveness of PMA-induced gene expression in insulin-desensitized cells.	Tetradecanoylphorbol Acetate	55-58	insulin	Homo sapiens	86-93
7988415-7	1994	In the present work, using insulin-desensitized H4 cells (insulin pretreatment for 24 h), subsequent treatment with PMA did not alter phosphoenolpyruvate carboxykinase transcription rates, whereas PMA did inhibit tyrosine aminotransferase transcription rates to an extent similar to observed in nonpretreated cells.	Tetradecanoylphorbol Acetate	116-119	insulin	Homo sapiens	58-65
7718953-0	1994	Impaired interleukin-2 production in active ulcerative colitis is reversed by calcium ionophore plus phorbol myristate acetate and related to altered intracellular Ca2+ responses.	Tetradecanoylphorbol Acetate	101-126	interleukin 2	Homo sapiens	9-22
7718953-3	1994	Depressed IL-2 production in active UC was not reversed by the addition of anti-CD3 monoclonal antibody plus phorbol myristate acetate (PMA), but was largely reversed by adding calcium ionophore plus PMA.	Tetradecanoylphorbol Acetate	136-139	interleukin 2	Homo sapiens	10-14
7718953-3	1994	Depressed IL-2 production in active UC was not reversed by the addition of anti-CD3 monoclonal antibody plus phorbol myristate acetate (PMA), but was largely reversed by adding calcium ionophore plus PMA.	Tetradecanoylphorbol Acetate	200-203	interleukin 2	Homo sapiens	10-14
7806568-7	1994	Short term TPA treatment (&lt; 30 min) increased phosphorylation of the gap junction protein molecular weight of 43,000 (Cx43), but did not change the cellular level of Cx43.	Tetradecanoylphorbol Acetate	11-14	gap junction protein, alpha 1	Rattus norvegicus	121-125
8002245-9	1994	These inhibitory effects of TGF-beta were augmented by pretreatment with either PMA or calphostin C. Pretreatment of the cells with PMA before stimulation with IFN-gamma downregulated HLA-DR expression.	Tetradecanoylphorbol Acetate	80-83	transforming growth factor beta 1	Homo sapiens	28-36
8002245-9	1994	These inhibitory effects of TGF-beta were augmented by pretreatment with either PMA or calphostin C. Pretreatment of the cells with PMA before stimulation with IFN-gamma downregulated HLA-DR expression.	Tetradecanoylphorbol Acetate	80-83	interferon gamma	Homo sapiens	160-169
8002245-9	1994	These inhibitory effects of TGF-beta were augmented by pretreatment with either PMA or calphostin C. Pretreatment of the cells with PMA before stimulation with IFN-gamma downregulated HLA-DR expression.	Tetradecanoylphorbol Acetate	132-135	transforming growth factor beta 1	Homo sapiens	28-36
8002245-12	1994	The modulation of these IFN-gamma and TGF-beta effects by calphostin C, staurosporine, and PMA treatment suggests involvement of the protein kinase C pathway.	Tetradecanoylphorbol Acetate	91-94	interferon gamma	Homo sapiens	24-33
8002245-12	1994	The modulation of these IFN-gamma and TGF-beta effects by calphostin C, staurosporine, and PMA treatment suggests involvement of the protein kinase C pathway.	Tetradecanoylphorbol Acetate	91-94	transforming growth factor beta 1	Homo sapiens	38-46
7861122-4	1994	The inhibition of PKC by sphingosine or by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) at high concentration greatly reduced the mean axonal length of spinal neurons cultured in medium conditioned by cerebellar astroglia (SCn-CBg), while activation of PKC by TPA at low concentration, or by retinoic acid, was not additive to the glial effect.	Tetradecanoylphorbol Acetate	99-102	proline rich transmembrane protein 2	Homo sapiens	18-21
7861122-5	1994	The activation of PKC by TPA or retinoic acid promoted axon growth of spinal neurons cultured in medium conditioned by spinal astroglia (SCn-SCg), which otherwise would not be as supportive for axon growth as cerebellar astroglia.	Tetradecanoylphorbol Acetate	25-28	proline rich transmembrane protein 2	Homo sapiens	18-21
7861122-4	1994	The inhibition of PKC by sphingosine or by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) at high concentration greatly reduced the mean axonal length of spinal neurons cultured in medium conditioned by cerebellar astroglia (SCn-CBg), while activation of PKC by TPA at low concentration, or by retinoic acid, was not additive to the glial effect.	Tetradecanoylphorbol Acetate	99-102	proline rich transmembrane protein 2	Homo sapiens	269-272
7861122-4	1994	The inhibition of PKC by sphingosine or by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) at high concentration greatly reduced the mean axonal length of spinal neurons cultured in medium conditioned by cerebellar astroglia (SCn-CBg), while activation of PKC by TPA at low concentration, or by retinoic acid, was not additive to the glial effect.	Tetradecanoylphorbol Acetate	276-279	proline rich transmembrane protein 2	Homo sapiens	18-21
7703311-6	1994	Treatment with TPA for 48 h induced the expression of TNF-alpha mRNA.	Tetradecanoylphorbol Acetate	15-18	tumor necrosis factor	Homo sapiens	54-63
7996483-3	1994	PC-SOD efficiently scavenged superoxide anion (O2-) produced by phorbol myristate acetate (PMA)-stimulated human neutrophils (IC50 0.60 U/ml), and it exerted a dose-dependent scavenging effect (IC50 1.27 U/ml) even when the neutrophils were washed after incubation with PC-SOD.	Tetradecanoylphorbol Acetate	64-89	superoxide dismutase 1	Homo sapiens	3-6
7996483-3	1994	PC-SOD efficiently scavenged superoxide anion (O2-) produced by phorbol myristate acetate (PMA)-stimulated human neutrophils (IC50 0.60 U/ml), and it exerted a dose-dependent scavenging effect (IC50 1.27 U/ml) even when the neutrophils were washed after incubation with PC-SOD.	Tetradecanoylphorbol Acetate	64-89	superoxide dismutase 1	Homo sapiens	273-276
7996483-3	1994	PC-SOD efficiently scavenged superoxide anion (O2-) produced by phorbol myristate acetate (PMA)-stimulated human neutrophils (IC50 0.60 U/ml), and it exerted a dose-dependent scavenging effect (IC50 1.27 U/ml) even when the neutrophils were washed after incubation with PC-SOD.	Tetradecanoylphorbol Acetate	91-94	superoxide dismutase 1	Homo sapiens	3-6
7996483-3	1994	PC-SOD efficiently scavenged superoxide anion (O2-) produced by phorbol myristate acetate (PMA)-stimulated human neutrophils (IC50 0.60 U/ml), and it exerted a dose-dependent scavenging effect (IC50 1.27 U/ml) even when the neutrophils were washed after incubation with PC-SOD.	Tetradecanoylphorbol Acetate	91-94	superoxide dismutase 1	Homo sapiens	273-276
7703311-7	1994	Treatment of these TPA-stimulated cells with estrogen caused a 62% decrease in TNF-alpha message abundance (p &lt; 0.01).	Tetradecanoylphorbol Acetate	19-22	tumor necrosis factor	Homo sapiens	79-88
7969133-6	1994	This is explained at least in part by the long-term downregulation of I kappa B alpha following CD28 signalling as opposed to phorbol myristate acetate alone.	Tetradecanoylphorbol Acetate	126-151	NFKB inhibitor alpha	Homo sapiens	70-85
7966593-2	1994	Treatment of cells with classical NF-kappa B inducers such as tumor necrosis factor, interleukin-1, phorbol myristate acetate, and lipopolysaccharide results in MAD3 degradation followed by nuclear translocation of NF-kappa B.	Tetradecanoylphorbol Acetate	100-125	nuclear factor kappa B subunit 1	Homo sapiens	34-44
7966593-2	1994	Treatment of cells with classical NF-kappa B inducers such as tumor necrosis factor, interleukin-1, phorbol myristate acetate, and lipopolysaccharide results in MAD3 degradation followed by nuclear translocation of NF-kappa B.	Tetradecanoylphorbol Acetate	100-125	NFKB inhibitor alpha	Homo sapiens	161-165
7966593-2	1994	Treatment of cells with classical NF-kappa B inducers such as tumor necrosis factor, interleukin-1, phorbol myristate acetate, and lipopolysaccharide results in MAD3 degradation followed by nuclear translocation of NF-kappa B.	Tetradecanoylphorbol Acetate	100-125	nuclear factor kappa B subunit 1	Homo sapiens	215-225
7954434-3	1994	Malignant human keratinocytes (A431, KB, HaCaT) and malignant human melanoma cells (KRFM) produced significant levels of both TNF-BPI and TNF-BPII on stimulation with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	167-192	tumor necrosis factor	Homo sapiens	126-129
11550712-6	1994	The PKC inhibitor, staurosporine, as well as PKC downregulation, were both found to inhibit PMA-induced PLD activity without inhibiting other PMA-induced effects in chondrocytes.	Tetradecanoylphorbol Acetate	92-95	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	104-107
7731274-6	1994	A significant increase in IL-6 production after mitogen stimulation with tetradecanoylphorbol acetate (TPA) and phytohemagglutinin (PHA) after 24 and 48 h of culture, as well as a greater induced TNF alpha production after 48 h of incubation with the same mitogens, was found in the anorectic patients as compared with the elderly controls.	Tetradecanoylphorbol Acetate	73-101	interleukin 6	Homo sapiens	26-30
7731274-6	1994	A significant increase in IL-6 production after mitogen stimulation with tetradecanoylphorbol acetate (TPA) and phytohemagglutinin (PHA) after 24 and 48 h of culture, as well as a greater induced TNF alpha production after 48 h of incubation with the same mitogens, was found in the anorectic patients as compared with the elderly controls.	Tetradecanoylphorbol Acetate	103-106	interleukin 6	Homo sapiens	26-30
7954411-3	1994	O2- generation, determined as O2- release from the PMA-stimulated cells by the reduction of cytochrome c, was dependent on the dose of PMA and reached almost maximal with 2.0 nM PMA.	Tetradecanoylphorbol Acetate	51-54	cytochrome c, somatic	Homo sapiens	92-104
7954411-3	1994	O2- generation, determined as O2- release from the PMA-stimulated cells by the reduction of cytochrome c, was dependent on the dose of PMA and reached almost maximal with 2.0 nM PMA.	Tetradecanoylphorbol Acetate	135-138	cytochrome c, somatic	Homo sapiens	92-104
7861298-1	1994	Superoxide anion (O2-) production by peripheral blood polymorphonuclear leukocytes (PMNs) stimulated with phorbol myristate acetate (PMA) was measured by the cytochrome C method in 57 patients with recurrent tonsillitis.	Tetradecanoylphorbol Acetate	106-131	cytochrome c, somatic	Homo sapiens	158-170
7526398-1	1994	Studies presented here show that overall NF-kappa B signal transduction begins with a parallel series of stimuli-specific pathways through which cytokines (tumor necrosis factor alpha), oxidants (hydrogen peroxide and mitomycin C), and phorbol ester (phorbol 12-myristate 13-acetate) individually initiate signaling.	Tetradecanoylphorbol Acetate	251-282	nuclear factor kappa B subunit 1	Homo sapiens	41-51
7526398-1	1994	Studies presented here show that overall NF-kappa B signal transduction begins with a parallel series of stimuli-specific pathways through which cytokines (tumor necrosis factor alpha), oxidants (hydrogen peroxide and mitomycin C), and phorbol ester (phorbol 12-myristate 13-acetate) individually initiate signaling.	Tetradecanoylphorbol Acetate	251-282	tumor necrosis factor	Homo sapiens	156-183
7798901-2	1994	Of particular interest are the Hg(II)-induced changes in the CD of d(ApT) and d(TpA): they are strongly sequence-dependent and, within reason, progress in a "mirror"-like fashion when the concentration of Hg(II) is varied.	Tetradecanoylphorbol Acetate	80-83	dacapo	Drosophila melanogaster	4-5
7954434-3	1994	Malignant human keratinocytes (A431, KB, HaCaT) and malignant human melanoma cells (KRFM) produced significant levels of both TNF-BPI and TNF-BPII on stimulation with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	167-192	tumor necrosis factor	Homo sapiens	138-141
7872662-7	1994	While staurosporine accelerates TGF beta 1-induced apoptosis in both 476-16 and T24 cells, 12-O-tetradecanoylphorbol 13-acetate inhibits TGF beta 1-induced apoptosis of 476-16 cells but stimulates that of T24 cells.	Tetradecanoylphorbol Acetate	91-127	transforming growth factor beta 1	Homo sapiens	137-147
7980611-4	1994	Pretreatment of the cells with PMA plus PTX completely inhibited the ET-1-augmented MAP kinase activity.	Tetradecanoylphorbol Acetate	31-34	endothelin 1	Rattus norvegicus	69-73
7981246-9	1994	Both activation of glycerophosphate dehydrogenase and stimulation of insulin-dependent 2-deoxyglucose uptake induced by hormones/IBMX were enhanced in protein kinase C-depleted cells exposed to phorbol 12-myristate 13-acetate (PMA), and attenuated in IAP-treated cells.	Tetradecanoylphorbol Acetate	194-225	insulin	Homo sapiens	69-76
7981246-9	1994	Both activation of glycerophosphate dehydrogenase and stimulation of insulin-dependent 2-deoxyglucose uptake induced by hormones/IBMX were enhanced in protein kinase C-depleted cells exposed to phorbol 12-myristate 13-acetate (PMA), and attenuated in IAP-treated cells.	Tetradecanoylphorbol Acetate	194-225	alkaline phosphatase, intestinal	Homo sapiens	251-254
7981246-9	1994	Both activation of glycerophosphate dehydrogenase and stimulation of insulin-dependent 2-deoxyglucose uptake induced by hormones/IBMX were enhanced in protein kinase C-depleted cells exposed to phorbol 12-myristate 13-acetate (PMA), and attenuated in IAP-treated cells.	Tetradecanoylphorbol Acetate	227-230	insulin	Homo sapiens	69-76
7872669-3	1994	IFN-gamma, all-trans retinoic acid and phorbol ester (TPA) induced up-regulation of CD66 antigen(s) recognized by the monoclonal antibody F34-187 (as determined by flow cytometry).	Tetradecanoylphorbol Acetate	54-57	interferon gamma	Homo sapiens	0-9
7923629-8	1994	To clarify the role of PKC in vasoconstrictor-stimulated VSMC production of bFGF and hypertrophy, PKC was down-regulated by prolonged exposure to PMA or was inhibited with calphostin C or staurosporine before the addition of TXA2 or Ang II.	Tetradecanoylphorbol Acetate	146-149	protein kinase C alpha	Homo sapiens	98-101
7703981-1	1994	The effect of phenyl- and benzylphthalimide analogs on tumor necrosis factor (TNF)-alpha production by a human leukemia cell line, HL-60, stimulated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was investigated.	Tetradecanoylphorbol Acetate	154-191	tumor necrosis factor	Homo sapiens	55-88
7923629-4	1994	Western analysis confirmed the presence of these isoforms in cultured VSMC lines and demonstrated downregulation of PKC alpha, delta, and epsilon by phorbol 12-myristate 13-acetate (PMA) but not TXA2 or Ang II.	Tetradecanoylphorbol Acetate	149-180	protein kinase C alpha	Homo sapiens	116-125
7884809-9	1994	This anion efflux was also sensitive to activation of protein kinase C since phorbol 12-myristate 13-acetate and phorbol, 12,13-dibutyrate blunted thrombin-mediated increases in 125I efflux.	Tetradecanoylphorbol Acetate	77-108	coagulation factor II, thrombin	Homo sapiens	147-155
7865515-7	1994	Activation of six additional isolates of lymphocytes with phorbol myristate acetate before exposure to human aortic endothelial cells resulted in an increase in human aortic endothelial cell-derived interleukin-6 bioactivity regardless of whether the cells were in direct contact with the human aortic endothelial cells, but the interleukin-6 level increase was approximately twofold higher in those cocultures where there was direct contact.	Tetradecanoylphorbol Acetate	58-83	interleukin 6	Homo sapiens	199-212
7865515-7	1994	Activation of six additional isolates of lymphocytes with phorbol myristate acetate before exposure to human aortic endothelial cells resulted in an increase in human aortic endothelial cell-derived interleukin-6 bioactivity regardless of whether the cells were in direct contact with the human aortic endothelial cells, but the interleukin-6 level increase was approximately twofold higher in those cocultures where there was direct contact.	Tetradecanoylphorbol Acetate	58-83	interleukin 6	Homo sapiens	329-342
7969070-1	1994	Bryostatin 1 and phorbol-12-myristate-13-acetate (PMA) are both potent activators of protein kinase C (PKC), although in primary mouse keratinocytes bryostatin 1 does not induce differentiation and blocks PMA-induced differentiation.	Tetradecanoylphorbol Acetate	17-48	protein kinase C, alpha	Mus musculus	103-106
7930608-8	1994	We also report that PAF enhances PMA-induced TNF-alpha production from human peripheral B cells.	Tetradecanoylphorbol Acetate	33-36	tumor necrosis factor	Homo sapiens	45-54
7969070-1	1994	Bryostatin 1 and phorbol-12-myristate-13-acetate (PMA) are both potent activators of protein kinase C (PKC), although in primary mouse keratinocytes bryostatin 1 does not induce differentiation and blocks PMA-induced differentiation.	Tetradecanoylphorbol Acetate	50-53	protein kinase C, alpha	Mus musculus	103-106
7935443-7	1994	Mitogenic stimulation of thymocytes with phorbol myristate acetate and ionomycin results in down-regulation of RAG-2 expression.	Tetradecanoylphorbol Acetate	41-66	recombination activating gene 2	Gallus gallus	111-116
7969070-1	1994	Bryostatin 1 and phorbol-12-myristate-13-acetate (PMA) are both potent activators of protein kinase C (PKC), although in primary mouse keratinocytes bryostatin 1 does not induce differentiation and blocks PMA-induced differentiation.	Tetradecanoylphorbol Acetate	205-208	protein kinase C, alpha	Mus musculus	103-106
7969070-5	1994	At a later time (6 hr), bryostatin 1 was 1-2 orders magnitude more potent than PMA for causing loss of PKC-alpha, -delta, and -epsilon from the soluble fraction.	Tetradecanoylphorbol Acetate	79-82	protein kinase C, alpha	Mus musculus	103-134
7969070-6	1994	Bryostatin 1 was 40-fold more potent than PMA for down-regulating PKC-alpha and showed a biphasic dose-response curve for down-regulating PKC-delta.	Tetradecanoylphorbol Acetate	42-45	protein kinase C, alpha	Mus musculus	66-75
7523496-5	1994	Cross-linking of CD7 or CD16 molecules with primary and secondary Abs, as well as stimulation of NK cells with phorbol ester (PMA) or with calcium ionophore A23187 also induced beta 1 integrin-mediated adhesion of these cells to fibronectin (FN)-coated plastic surfaces.	Tetradecanoylphorbol Acetate	126-129	fibronectin 1	Homo sapiens	229-240
7936644-0	1994	Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro.	Tetradecanoylphorbol Acetate	16-19	proline rich transmembrane protein 2	Homo sapiens	43-59
7936644-0	1994	Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro.	Tetradecanoylphorbol Acetate	16-19	mitogen-activated protein kinase kinase 7	Homo sapiens	69-72
7936644-2	1994	The largest known family of TPA-binding proteins comprise members of the protein kinase C (PKC) family although other TPA-binding proteins outside the PKC family have recently been identified.	Tetradecanoylphorbol Acetate	28-31	proline rich transmembrane protein 2	Homo sapiens	73-89
7936644-2	1994	The largest known family of TPA-binding proteins comprise members of the protein kinase C (PKC) family although other TPA-binding proteins outside the PKC family have recently been identified.	Tetradecanoylphorbol Acetate	28-31	proline rich transmembrane protein 2	Homo sapiens	91-94
7936644-2	1994	The largest known family of TPA-binding proteins comprise members of the protein kinase C (PKC) family although other TPA-binding proteins outside the PKC family have recently been identified.	Tetradecanoylphorbol Acetate	28-31	proline rich transmembrane protein 2	Homo sapiens	151-154
7936644-2	1994	The largest known family of TPA-binding proteins comprise members of the protein kinase C (PKC) family although other TPA-binding proteins outside the PKC family have recently been identified.	Tetradecanoylphorbol Acetate	118-121	proline rich transmembrane protein 2	Homo sapiens	73-89
7936644-2	1994	The largest known family of TPA-binding proteins comprise members of the protein kinase C (PKC) family although other TPA-binding proteins outside the PKC family have recently been identified.	Tetradecanoylphorbol Acetate	118-121	proline rich transmembrane protein 2	Homo sapiens	91-94
7936644-2	1994	The largest known family of TPA-binding proteins comprise members of the protein kinase C (PKC) family although other TPA-binding proteins outside the PKC family have recently been identified.	Tetradecanoylphorbol Acetate	118-121	proline rich transmembrane protein 2	Homo sapiens	151-154
7936644-4	1994	Using recombinant proteins and in vitro phosphorylation reactions we identified the components in the signal transduction pathway from TPA to MAPkinase and we show that the activation of MAPkinase by TPA requires the presence of protein kinase C, c-raf and the MAPkinase activator MEK.	Tetradecanoylphorbol Acetate	135-138	proline rich transmembrane protein 2	Homo sapiens	229-245
7936644-4	1994	Using recombinant proteins and in vitro phosphorylation reactions we identified the components in the signal transduction pathway from TPA to MAPkinase and we show that the activation of MAPkinase by TPA requires the presence of protein kinase C, c-raf and the MAPkinase activator MEK.	Tetradecanoylphorbol Acetate	135-138	mitogen-activated protein kinase kinase 7	Homo sapiens	281-284
7936644-4	1994	Using recombinant proteins and in vitro phosphorylation reactions we identified the components in the signal transduction pathway from TPA to MAPkinase and we show that the activation of MAPkinase by TPA requires the presence of protein kinase C, c-raf and the MAPkinase activator MEK.	Tetradecanoylphorbol Acetate	200-203	proline rich transmembrane protein 2	Homo sapiens	229-245
7936644-4	1994	Using recombinant proteins and in vitro phosphorylation reactions we identified the components in the signal transduction pathway from TPA to MAPkinase and we show that the activation of MAPkinase by TPA requires the presence of protein kinase C, c-raf and the MAPkinase activator MEK.	Tetradecanoylphorbol Acetate	200-203	mitogen-activated protein kinase kinase 7	Homo sapiens	281-284
7900083-5	1994	In a megakaryocytic cell line UT-7, GPV antigen increased after treatment with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	79-110	glycoprotein V platelet	Homo sapiens	36-39
7900083-5	1994	In a megakaryocytic cell line UT-7, GPV antigen increased after treatment with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	112-115	glycoprotein V platelet	Homo sapiens	36-39
7526342-1	1994	The expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene can be down-regulated by inflammatory stimuli such as phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	140-165	CF transmembrane conductance regulator	Homo sapiens	22-73
7526342-1	1994	The expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene can be down-regulated by inflammatory stimuli such as phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	140-165	CF transmembrane conductance regulator	Homo sapiens	75-79
7526342-1	1994	The expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene can be down-regulated by inflammatory stimuli such as phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	167-170	CF transmembrane conductance regulator	Homo sapiens	22-73
7526342-1	1994	The expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene can be down-regulated by inflammatory stimuli such as phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	167-170	CF transmembrane conductance regulator	Homo sapiens	75-79
7526844-3	1994	Here we report that addition of the biologically active phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), dose-dependently inhibited the IL-1 beta-stimulated increase in iNOS mRNA levels and nitrite production.	Tetradecanoylphorbol Acetate	72-103	interleukin 1 beta	Rattus norvegicus	178-187
7526844-3	1994	Here we report that addition of the biologically active phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), dose-dependently inhibited the IL-1 beta-stimulated increase in iNOS mRNA levels and nitrite production.	Tetradecanoylphorbol Acetate	72-103	nitric oxide synthase 2	Rattus norvegicus	211-215
7526844-3	1994	Here we report that addition of the biologically active phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), dose-dependently inhibited the IL-1 beta-stimulated increase in iNOS mRNA levels and nitrite production.	Tetradecanoylphorbol Acetate	105-108	interleukin 1 beta	Rattus norvegicus	178-187
7526844-3	1994	Here we report that addition of the biologically active phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), dose-dependently inhibited the IL-1 beta-stimulated increase in iNOS mRNA levels and nitrite production.	Tetradecanoylphorbol Acetate	105-108	nitric oxide synthase 2	Rattus norvegicus	211-215
7936668-4	1994	mda-6 gene expression in HL-60 cells is induced within 1 to 3 h during differentiation along the macrophage/monocyte pathway evoked by 12-0-tetradecanoyl phorbol-13-acetate (TPA) or 1,25-dihydroxyvitamin D3 (Vit D3) or the granulocytic pathway produced by retinoic acid (RA) or dimethylsulfoxide (DMSO).	Tetradecanoylphorbol Acetate	174-177	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-5
7936668-5	1994	Immunoprecipitation analyses using an anti-p21 antibody indicate a temporal induction of p21 protein following treatment with TPA, DMSO or RA.	Tetradecanoylphorbol Acetate	126-129	cyclin dependent kinase inhibitor 1A	Homo sapiens	43-46
7936668-5	1994	Immunoprecipitation analyses using an anti-p21 antibody indicate a temporal induction of p21 protein following treatment with TPA, DMSO or RA.	Tetradecanoylphorbol Acetate	126-129	cyclin dependent kinase inhibitor 1A	Homo sapiens	89-92
7936668-6	1994	A relationship between rapid induction of mda-6 gene expression and differentiation is indicated by a delay in this expression in an HL-60 cell variant resistant to TPA-induced growth arrest and differentiation.	Tetradecanoylphorbol Acetate	165-168	cyclin dependent kinase inhibitor 1A	Homo sapiens	42-47
7881866-8	1994	Rhodanese formation of SCN- decreased when the preincubation was conducted with 1 nM or 100 nM of TPA.	Tetradecanoylphorbol Acetate	98-101	thiosulfate sulfurtransferase	Bos taurus	0-9
7881866-9	1994	With HI-6 at 1 or 10 microM used in place of PKC, or TPA, rhodanese activity was increased by 6 or 14% (P &lt; 0.05), respectively, compared to control.	Tetradecanoylphorbol Acetate	53-56	thiosulfate sulfurtransferase	Bos taurus	58-67
7929360-5	1994	On the other hand, epidermal growth factor causes a prolonged activation of Raf-1 kinase and ERK activity and a smaller, more transient activation of JNK, whereas the phorbol ester phorbol 12-myristate 13-acetate causes a small stimulation of Raf-1 kinase and a pronounced stimulation of ERK activity.	Tetradecanoylphorbol Acetate	181-212	mitogen-activated protein kinase 1	Homo sapiens	288-291
7929360-7	1994	The kinetics of Raf-1, ERK, and JNK induction by epidermal growth factor, phorbol 12-myristate 13-acetate, or TNF alpha indicate distinct mechanisms of activation in human fibroblasts.	Tetradecanoylphorbol Acetate	74-105	mitogen-activated protein kinase 8	Homo sapiens	32-35
7948035-7	1994	The amounts of p47-phox and p67-phox translocated to the plasma membrane in response to phorbol myristate acetate (PMA) increased with increasing amounts of cytochrome b-558 in the membrane.	Tetradecanoylphorbol Acetate	88-113	CD33 molecule	Homo sapiens	28-31
7948035-7	1994	The amounts of p47-phox and p67-phox translocated to the plasma membrane in response to phorbol myristate acetate (PMA) increased with increasing amounts of cytochrome b-558 in the membrane.	Tetradecanoylphorbol Acetate	115-118	CD33 molecule	Homo sapiens	28-31
7919371-6	1994	This was corroborated by data showing that IL-6 production in these cells was induced by combined stimulation with ionomycin and phorbol myristate acetate, thereby bypassing the effects of IP3 and DAG, respectively.	Tetradecanoylphorbol Acetate	129-154	interleukin 6	Rattus norvegicus	43-47
7523496-5	1994	Cross-linking of CD7 or CD16 molecules with primary and secondary Abs, as well as stimulation of NK cells with phorbol ester (PMA) or with calcium ionophore A23187 also induced beta 1 integrin-mediated adhesion of these cells to fibronectin (FN)-coated plastic surfaces.	Tetradecanoylphorbol Acetate	126-129	fibronectin 1	Homo sapiens	242-244
7980409-6	1994	After stimulation with phorbol 12-myristate 13-acetate and phytohaemagglutinin for 10 min, p105-NF-kappa B and p50-NF-kappa B, but not p36-I kappa B, were highly phosphorylated.	Tetradecanoylphorbol Acetate	23-54	nuclear factor kappa B subunit 1	Homo sapiens	91-95
7980409-6	1994	After stimulation with phorbol 12-myristate 13-acetate and phytohaemagglutinin for 10 min, p105-NF-kappa B and p50-NF-kappa B, but not p36-I kappa B, were highly phosphorylated.	Tetradecanoylphorbol Acetate	23-54	nuclear factor kappa B subunit 1	Homo sapiens	96-106
7980409-6	1994	After stimulation with phorbol 12-myristate 13-acetate and phytohaemagglutinin for 10 min, p105-NF-kappa B and p50-NF-kappa B, but not p36-I kappa B, were highly phosphorylated.	Tetradecanoylphorbol Acetate	23-54	nuclear factor kappa B subunit 1	Homo sapiens	111-114
7980409-6	1994	After stimulation with phorbol 12-myristate 13-acetate and phytohaemagglutinin for 10 min, p105-NF-kappa B and p50-NF-kappa B, but not p36-I kappa B, were highly phosphorylated.	Tetradecanoylphorbol Acetate	23-54	nuclear factor kappa B subunit 1	Homo sapiens	115-125
7929214-6	1994	Shc-PTP-PEST complex formation was stimulated 6-8-fold by the protein kinase C activator phorbol 12-myristate 13-acetate, while epidermal growth factor and serum had no effect.	Tetradecanoylphorbol Acetate	89-120	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	4-12
7923875-2	1994	Upon stimulation with allergen or anti-CD3+ phorbol myristate acetate (PMA) IL-4 was released with or without IL-5, while no (or extremely low concentrations of) IL-2 and interferon-gamma (IFN-gamma) were detectable.	Tetradecanoylphorbol Acetate	44-69	interleukin 4	Homo sapiens	76-80
7945348-2	1994	Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after treatment with recombinant interferon-gamma (rIFN-gamma) resulted in the increased production of NO in the medium.	Tetradecanoylphorbol Acetate	58-89	interferon gamma	Mus musculus	129-145
7945348-2	1994	Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after treatment with recombinant interferon-gamma (rIFN-gamma) resulted in the increased production of NO in the medium.	Tetradecanoylphorbol Acetate	91-94	interferon gamma	Mus musculus	129-145
7943374-6	1994	Even after protein kinase C (PKC) activity was functionally depleted by treating VSMC with phorbol 12-myristate 13-acetate (10(-6) M) for 24 h, angiotensin II increased alpha 1-mRNA accumulation.	Tetradecanoylphorbol Acetate	91-122	angiotensinogen	Rattus norvegicus	144-158
7944397-4	1994	Of the two major substrates of PLD, phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), vitamin K3 (10-100 microM) preferentially inhibited PtdEtn hydrolysis when stimulated by PMA or platelet-derived growth factor, the latter being a hormonal activator of PKC.	Tetradecanoylphorbol Acetate	193-196	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-34
7945244-6	1994	A role for cAMP in PMA-induced ANP secretion was also apparent insofar as PMA-induced ANP release was substantially decreased in the presence of the Rp-diastereomer of 3",5"-cyclic adenosine monophosphorothioate (Rp-cAMPS; 10 microM), whereas the cAMP-mimetic agent dibutyryl cAMP (10 microM) provoked a rapid increase in ANP secretion in this system.	Tetradecanoylphorbol Acetate	19-22	calmodulin 2, pseudogene 1	Rattus norvegicus	216-221
7945248-0	1994	Role of phospholipase A2 in expression of the scavenger pathway in cultured aortic smooth muscle cells stimulated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	119-150	phospholipase A2 group IB	Homo sapiens	8-24
7945248-6	1994	Induction of expression of the scavenger pathway by PMA was not inhibited by protein kinase C inhibitors, but was inhibited about 50% by phospholipase A2 inhibitors.	Tetradecanoylphorbol Acetate	52-55	phospholipase A2 group IB	Homo sapiens	137-153
7529614-10	1994	A synergistic effect on TNF-alpha production was also found with the enzymes and phorbol ester (PMA).	Tetradecanoylphorbol Acetate	96-99	tumor necrosis factor	Homo sapiens	24-33
7945240-6	1994	Retinoic acid (RA) and phorbol 12-myristate 13-acetate also substantially reduced the dexamethasone-induced expression of ALP.	Tetradecanoylphorbol Acetate	23-54	alkaline phosphatase, placental	Homo sapiens	122-125
8087865-7	1994	In contrast, PMA-induced IL-2-independent proliferation of human T cells appears to be dependent on the continuous presence of cPKC (that may mediate some critical events at late stages of the response) and, therefore, is inhibited by bryostatin, that induces a rapid degradation of potentially active cPKC.	Tetradecanoylphorbol Acetate	13-16	interleukin 2	Homo sapiens	25-29
8087866-10	1994	The fact that PKC inhibitor staurosporine blocks PMA- but not CD16-induced downregulation suggests that CD16 downregulation can be achieved via two different pathways: one that is PKC dependent and one that is not.	Tetradecanoylphorbol Acetate	49-52	proline rich transmembrane protein 2	Homo sapiens	14-17
7923875-2	1994	Upon stimulation with allergen or anti-CD3+ phorbol myristate acetate (PMA) IL-4 was released with or without IL-5, while no (or extremely low concentrations of) IL-2 and interferon-gamma (IFN-gamma) were detectable.	Tetradecanoylphorbol Acetate	71-74	interleukin 4	Homo sapiens	76-80
7925647-2	1994	Enhancement of cell adhesion to fibronectin was also observed on treatment of HL60 cells with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	94-130	fibronectin 1	Homo sapiens	32-43
7523156-8	1994	EGF and TNF-alpha could enhance c-fos gene expression when protein kinase C was down-regulated by phorbol ester myristate (PMA).	Tetradecanoylphorbol Acetate	123-126	tumor necrosis factor	Homo sapiens	8-17
7925647-2	1994	Enhancement of cell adhesion to fibronectin was also observed on treatment of HL60 cells with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	132-135	fibronectin 1	Homo sapiens	32-43
7925438-11	1994	Similar to PKC-alpha, transient PKC-theta overexpression in murine EL4 thymoma cells caused an approximately 2.5-fold increase in the phorbol-12-myristate-13-acetate-induced transcriptional activation of an interleukin-2 promoter-reporter gene construct.	Tetradecanoylphorbol Acetate	134-165	protein kinase C, alpha	Mus musculus	11-20
7925647-5	1994	Cell adhesion to fibronectin before and after treatment with BZ alpha GalNAc or TPA was inhibited by anti-VLA4 and anti-VLA5 monoclonal antibodies.	Tetradecanoylphorbol Acetate	80-83	fibronectin 1	Homo sapiens	17-28
7925647-5	1994	Cell adhesion to fibronectin before and after treatment with BZ alpha GalNAc or TPA was inhibited by anti-VLA4 and anti-VLA5 monoclonal antibodies.	Tetradecanoylphorbol Acetate	80-83	integrin subunit alpha 5	Homo sapiens	120-124
7875527-7	1994	Consequently, the binding activity of c-Jun protein to the TPA-responsive element increases, and this causes the induction of PPET-1 mRNA.	Tetradecanoylphorbol Acetate	59-62	endothelin 1	Homo sapiens	126-132
7925647-7	1994	Labeling of cell surface carbohydrates with [3H]-glucosamine followed by treatment with TPA revealed that O-glycosylated glycoproteins including CD43 were released from the cell surface during this treatment.	Tetradecanoylphorbol Acetate	88-91	sialophorin	Homo sapiens	145-149
7930675-6	1994	Auranofin and staurosporine, inhibitors of protein kinase C, inhibited phorbol-myristate-acetate-stimulated IL-8 production.	Tetradecanoylphorbol Acetate	71-96	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
7883762-7	1994	Furthermore, evidence is presented which indicates a synergistic effect of A23187 and thrombin on the activation of p72syk, and an inhibitory effect of pretreatment with phorbol 12-myristate 13-acetate, a protein kinase C activator, on the activation of p72syk induced by either A23187 or thrombin.	Tetradecanoylphorbol Acetate	170-201	coagulation factor II, thrombin	Homo sapiens	289-297
7523530-6	1994	Upon stimulation with phorbol myristate acetate and A23187, cultured cells showed substantially more release of IL-3 and TNF-alpha after 14 d of culture, compared to peripheral blood monocytic cells.	Tetradecanoylphorbol Acetate	22-47	tumor necrosis factor	Homo sapiens	121-130
7929563-11	1994	The regulation of bFGF protein content also involves posttranscriptional mechanisms since changes in the levels of individual bFGF isoforms were different depending on whether cells were treated with carbachol or angiotensin II, forskolin, or PMA.	Tetradecanoylphorbol Acetate	243-246	fibroblast growth factor 2	Homo sapiens	18-22
7757523-5	1994	Stimulation of LPS- and TNF-treated PMN with phorbol 12-myristate 13-acetate (PMA), opsonized zymosan (OPZ), and anti-rat CD11b/c MAb triggered O2- generation.	Tetradecanoylphorbol Acetate	45-76	tumor necrosis factor	Rattus norvegicus	24-27
7931079-11	1994	Therefore, we propose that the TPA/calcium-activated AP-1/OAP element is the main target of positive or negative regulatory signals influencing the IL-2 octamer motif, through synergism with Oct-2 and antagonism by RAR.	Tetradecanoylphorbol Acetate	31-34	interleukin 2	Homo sapiens	148-152
7854349-7	1994	The Pit-1 gene promoter region between -210 and -142 from the transcription start site conferred synergistic regulation by DEX and TPA when placed upstream of position -105 in the herpes viral thymidine kinase promoter.	Tetradecanoylphorbol Acetate	131-134	POU class 1 homeobox 1	Rattus norvegicus	4-9
7931079-1	1994	The differentiating agent retinoic acid (RA) has been previously reported to interfere with 12-O-tetradecanoyl-phorbol-13-acetate (TPA)/Ca2+-induced signals for the regulation of the -96 to -66-bp octamer motif found in the enhancer for the interleukin (IL)-2 gene, which encodes a major T lymphocyte growth factor.	Tetradecanoylphorbol Acetate	92-129	interleukin 2	Homo sapiens	241-259
7931079-1	1994	The differentiating agent retinoic acid (RA) has been previously reported to interfere with 12-O-tetradecanoyl-phorbol-13-acetate (TPA)/Ca2+-induced signals for the regulation of the -96 to -66-bp octamer motif found in the enhancer for the interleukin (IL)-2 gene, which encodes a major T lymphocyte growth factor.	Tetradecanoylphorbol Acetate	131-134	interleukin 2	Homo sapiens	241-259
7931079-2	1994	The IL-2 octamer motif is a composite cis-element which binds Oct-1 and Oct-2 as well as a TPA/Ca2+-inducible nuclear factor, previously termed octamer-associated protein (OAP40).	Tetradecanoylphorbol Acetate	91-94	interleukin 2	Homo sapiens	4-8
7931079-3	1994	We show here that Oct-2, despite the presence of an active transcriptional activation domain, requires TPA/Ca2+-induced signals to strongly transactivate the IL-2 octamer motif in Jurkat T cells.	Tetradecanoylphorbol Acetate	103-106	interleukin 2	Homo sapiens	158-162
7930942-1	1994	A study was performed to elucidate the effect of two commonly used fluorescent dyes in in vivo microscopic studies, acridine orange (AO) and acridine red (AR), on the ability of phorbol myristate acetate (PMA)- or formyl peptide (fMLP)-stimulated human neutrophils to adhere to a bovine serum albumin matrix and to generate superoxide anions (SOX).	Tetradecanoylphorbol Acetate	178-203	formyl peptide receptor 1	Homo sapiens	230-234
7930942-1	1994	A study was performed to elucidate the effect of two commonly used fluorescent dyes in in vivo microscopic studies, acridine orange (AO) and acridine red (AR), on the ability of phorbol myristate acetate (PMA)- or formyl peptide (fMLP)-stimulated human neutrophils to adhere to a bovine serum albumin matrix and to generate superoxide anions (SOX).	Tetradecanoylphorbol Acetate	205-208	formyl peptide receptor 1	Homo sapiens	230-234
7947349-3	1994	The protein kinase C activator, phorbol 12-myristate, 13-acetate (PMA) increased the Kd of the EGF receptor in a dose dependent manner (PMA: 0, 1, 10, 100 nM; Kd: 4.1, 5, 10, 50 nM, respectively).	Tetradecanoylphorbol Acetate	32-64	epidermal growth factor receptor	Homo sapiens	95-98
7947349-3	1994	The protein kinase C activator, phorbol 12-myristate, 13-acetate (PMA) increased the Kd of the EGF receptor in a dose dependent manner (PMA: 0, 1, 10, 100 nM; Kd: 4.1, 5, 10, 50 nM, respectively).	Tetradecanoylphorbol Acetate	66-69	epidermal growth factor receptor	Homo sapiens	95-98
7935389-1	1994	The cytoplasmic Raf-1 kinase is essential for mitogenic signalling by growth factors, which couple to tyrosine kinases, and by tumor-promoting phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate, which activate protein kinase C (PKC).	Tetradecanoylphorbol Acetate	166-202	protein kinase C alpha	Homo sapiens	237-240
7757523-5	1994	Stimulation of LPS- and TNF-treated PMN with phorbol 12-myristate 13-acetate (PMA), opsonized zymosan (OPZ), and anti-rat CD11b/c MAb triggered O2- generation.	Tetradecanoylphorbol Acetate	78-81	tumor necrosis factor	Rattus norvegicus	24-27
7929090-6	1994	The phosphotyrosine content of p125FAK, paxillin, and p130 was also increased following stimulation with phorbol 12-myristate 13-acetate (PMA) (0.1 microM).	Tetradecanoylphorbol Acetate	105-136	paxillin	Mus musculus	40-48
8091645-8	1994	Treatment with TPA or retinoic acid led to enhanced expression of the IE2 gene and the early genes encoding pp65 (UL83) and p52 (UL44).	Tetradecanoylphorbol Acetate	15-18	nuclear factor kappa B subunit 2	Homo sapiens	124-127
7929090-6	1994	The phosphotyrosine content of p125FAK, paxillin, and p130 was also increased following stimulation with phorbol 12-myristate 13-acetate (PMA) (0.1 microM).	Tetradecanoylphorbol Acetate	105-136	nucleolar and coiled-body phosphoprotein 1	Mus musculus	54-58
7929090-6	1994	The phosphotyrosine content of p125FAK, paxillin, and p130 was also increased following stimulation with phorbol 12-myristate 13-acetate (PMA) (0.1 microM).	Tetradecanoylphorbol Acetate	138-141	paxillin	Mus musculus	40-48
7929090-6	1994	The phosphotyrosine content of p125FAK, paxillin, and p130 was also increased following stimulation with phorbol 12-myristate 13-acetate (PMA) (0.1 microM).	Tetradecanoylphorbol Acetate	138-141	nucleolar and coiled-body phosphoprotein 1	Mus musculus	54-58
8083220-1	1994	pip92 is an immediate early gene that is transcriptionally activated in mouse 3T3 fibroblasts upon treatment with serum growth factors or the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	157-193	immediate early response 2	Mus musculus	0-5
8093086-2	1994	First, the PKC-activity was induced by phorbol 12-myristate 13-acetate (PMA) before the stimulation of Ca2+-signal with N-formyl-methionyl-leucyl-phenylalanine and serum-opsonized zymosan particles.	Tetradecanoylphorbol Acetate	39-70	proline rich transmembrane protein 2	Homo sapiens	11-14
7945188-6	1994	These data indicate that MCF-7/MDR cells contain a PtdEtn-specific PLD activity which can be selectively stimulated by PMA, sphingosine and H2O2.	Tetradecanoylphorbol Acetate	119-122	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	67-70
8086474-5	1994	A detailed time course study showed that the VDUP1 mRNA starts to increase at 6 h after 1,25-dihydroxyvitamin D-3 treatment, reaches a plateau at around 18 h and stays elevated for 24 h. The VDUP1 mRNA is not regulated by phorbol 12-myristate 13-acetate (PMA) in HL-60 cells.	Tetradecanoylphorbol Acetate	222-253	thioredoxin interacting protein	Homo sapiens	45-50
8086474-5	1994	A detailed time course study showed that the VDUP1 mRNA starts to increase at 6 h after 1,25-dihydroxyvitamin D-3 treatment, reaches a plateau at around 18 h and stays elevated for 24 h. The VDUP1 mRNA is not regulated by phorbol 12-myristate 13-acetate (PMA) in HL-60 cells.	Tetradecanoylphorbol Acetate	222-253	thioredoxin interacting protein	Homo sapiens	191-196
7847852-7	1994	Flow immunocytometry revealed reduced levels of c-myc and bcl-2 oncoproteins in RA and PMA treated cells.	Tetradecanoylphorbol Acetate	87-90	BCL2 apoptosis regulator	Homo sapiens	58-63
8093011-4	1994	In the presence of 4 beta-phorbol 12-myristate 13-acetate (4 beta-PMA; "TPA"), the lysosomal packaging of lysozyme is almost completely inhibited, while that of procathepsin D is only partially so.	Tetradecanoylphorbol Acetate	19-57	lysozyme	Homo sapiens	106-114
8093011-4	1994	In the presence of 4 beta-phorbol 12-myristate 13-acetate (4 beta-PMA; "TPA"), the lysosomal packaging of lysozyme is almost completely inhibited, while that of procathepsin D is only partially so.	Tetradecanoylphorbol Acetate	72-75	lysozyme	Homo sapiens	106-114
7841962-0	1994	Enhancement of 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor alpha production by phenethylphthalimide analogs.	Tetradecanoylphorbol Acetate	15-51	tumor necrosis factor	Homo sapiens	60-87
7841962-1	1994	Effects of phenyl-, benzyl-, phenethyl-, and phenylpropylphthalimides on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor necrosis factor (TNF)-alpha production by human leukemia cell line HL-60 were examined.	Tetradecanoylphorbol Acetate	73-109	tumor necrosis factor	Homo sapiens	147-157
7841962-1	1994	Effects of phenyl-, benzyl-, phenethyl-, and phenylpropylphthalimides on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor necrosis factor (TNF)-alpha production by human leukemia cell line HL-60 were examined.	Tetradecanoylphorbol Acetate	111-114	tumor necrosis factor	Homo sapiens	147-157
7915976-2	1994	Both peripheral blood mononuclear cells and IL-2-dependent T cell lines derived from the patient showed a severe selective T cell activation impairment via CD2, CD3 and CD43; however, this defect was reversible with the addition of either IL-2, or phorbol myristate acetate (PMA) or anti-CD28 antibodies.	Tetradecanoylphorbol Acetate	275-278	interleukin 2	Homo sapiens	44-48
8086474-5	1994	A detailed time course study showed that the VDUP1 mRNA starts to increase at 6 h after 1,25-dihydroxyvitamin D-3 treatment, reaches a plateau at around 18 h and stays elevated for 24 h. The VDUP1 mRNA is not regulated by phorbol 12-myristate 13-acetate (PMA) in HL-60 cells.	Tetradecanoylphorbol Acetate	255-258	thioredoxin interacting protein	Homo sapiens	45-50
8086474-5	1994	A detailed time course study showed that the VDUP1 mRNA starts to increase at 6 h after 1,25-dihydroxyvitamin D-3 treatment, reaches a plateau at around 18 h and stays elevated for 24 h. The VDUP1 mRNA is not regulated by phorbol 12-myristate 13-acetate (PMA) in HL-60 cells.	Tetradecanoylphorbol Acetate	255-258	thioredoxin interacting protein	Homo sapiens	191-196
7943245-3	1994	1,25(OH)2D3 and the PKC activator 12-O-tetradecanoylphorbol 13-acetate (TPA) each caused time-dependent translocations of PKC-alpha, but not PKC-zeta.	Tetradecanoylphorbol Acetate	34-70	protein kinase C alpha	Homo sapiens	122-131
7943245-3	1994	1,25(OH)2D3 and the PKC activator 12-O-tetradecanoylphorbol 13-acetate (TPA) each caused time-dependent translocations of PKC-alpha, but not PKC-zeta.	Tetradecanoylphorbol Acetate	72-75	protein kinase C alpha	Homo sapiens	122-131
7943245-4	1994	TPA treatment of these cells for 24 h induced a significant concentration-dependent downregulation of PKC-alpha, but not PKC-zeta.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	102-111
7943245-8	1994	Acute pretreatment with staurosporine or H-7 caused a significant stimulation, whereas acute TPA pretreatment caused a significant inhibition of the 1,25(OH)2D3-induced increase in the transient phase of [Ca2+]i. Preincubation of Caco-2 cells with 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-acetoxy-methyl ester (BAPTA-AM) abolished both the rise in [Ca2+]i and the increase in particulate-associated PKC-alpha stimulated by 1,25(OH)2D3.	Tetradecanoylphorbol Acetate	93-96	protein kinase C alpha	Homo sapiens	415-424
7943245-9	1994	Moreover, downregulation of PKC-alpha by chronic TPA treatment significantly augmented the transient phase of the 1,25(OH)2D3-stimulated rise in [Ca2+]i but had no effect on the 1,25(OH)2D3-induced change in Ins(1,4,5)P3 concentration.	Tetradecanoylphorbol Acetate	49-52	protein kinase C alpha	Homo sapiens	28-37
8092274-3	1994	Fibrinogen-mediated aggregation of washed platelets was inhibited by ATP and 8-azido-ATP in a dose-dependent manner, independent of the agonist (thrombin, collagen, epinephrine, phorbol 12-myristate 13-acetate) used to induce platelet activation.	Tetradecanoylphorbol Acetate	178-209	fibrinogen beta chain	Homo sapiens	0-10
8068954-3	1994	C1q-R expression was not upregulated upon warming, priming, or exposure to FMLP, but decreased after exposure to phorbol myristate acetate (PMA), because of shedding of the receptor into the extracellular medium, as detected by enzyme-linked immunosorbent assay.	Tetradecanoylphorbol Acetate	113-138	CD93 molecule	Homo sapiens	0-5
8068954-3	1994	C1q-R expression was not upregulated upon warming, priming, or exposure to FMLP, but decreased after exposure to phorbol myristate acetate (PMA), because of shedding of the receptor into the extracellular medium, as detected by enzyme-linked immunosorbent assay.	Tetradecanoylphorbol Acetate	140-143	CD93 molecule	Homo sapiens	0-5
7915976-2	1994	Both peripheral blood mononuclear cells and IL-2-dependent T cell lines derived from the patient showed a severe selective T cell activation impairment via CD2, CD3 and CD43; however, this defect was reversible with the addition of either IL-2, or phorbol myristate acetate (PMA) or anti-CD28 antibodies.	Tetradecanoylphorbol Acetate	248-273	interleukin 2	Homo sapiens	44-48
8093086-2	1994	First, the PKC-activity was induced by phorbol 12-myristate 13-acetate (PMA) before the stimulation of Ca2+-signal with N-formyl-methionyl-leucyl-phenylalanine and serum-opsonized zymosan particles.	Tetradecanoylphorbol Acetate	72-75	proline rich transmembrane protein 2	Homo sapiens	11-14
7921204-5	1994	The stimulatory effect of dexamethasone on POMC gene expression was inhibited 70% by nerve growth factor (NGF, 200 micrograms/l), 30% by 12-O-tetradecanoyl phorbol 13-acetate (TPA, 160 nmol/l) (a protein kinase-C activator) and 30% by (Bu)2cAMP (1 mmol/l).	Tetradecanoylphorbol Acetate	137-174	proopiomelanocortin	Homo sapiens	43-47
7921204-5	1994	The stimulatory effect of dexamethasone on POMC gene expression was inhibited 70% by nerve growth factor (NGF, 200 micrograms/l), 30% by 12-O-tetradecanoyl phorbol 13-acetate (TPA, 160 nmol/l) (a protein kinase-C activator) and 30% by (Bu)2cAMP (1 mmol/l).	Tetradecanoylphorbol Acetate	176-179	proopiomelanocortin	Homo sapiens	43-47
8082304-3	1994	Children with atopic dermatitis were found to have constitutive expression of IFN-gamma mRNA in freshly isolated peripheral blood mononuclear cells (PBMC) and in unstimulated PBMC cultures which increased further following stimulation with phorbol myristate acetate (PMA)/Ca in vitro.	Tetradecanoylphorbol Acetate	240-265	interferon gamma	Homo sapiens	78-87
8082304-3	1994	Children with atopic dermatitis were found to have constitutive expression of IFN-gamma mRNA in freshly isolated peripheral blood mononuclear cells (PBMC) and in unstimulated PBMC cultures which increased further following stimulation with phorbol myristate acetate (PMA)/Ca in vitro.	Tetradecanoylphorbol Acetate	267-270	interferon gamma	Homo sapiens	78-87
7921204-6	1994	On the other hand, NGF alone increased the CRH mRNA accumulation up to 10-fold, and further enhanced the stimulatory effect of dexamethasone on the CRH mRNA twofold, and TPA inhibited (30%) the dexamethasone-induced CRH mRNA accumulation.	Tetradecanoylphorbol Acetate	170-173	nerve growth factor	Homo sapiens	19-22
7868057-13	1994	Although delayed addition of TPA enhanced IL-6-dependent colony formation, delayed addition of TPA with either the PKC inhibitor or TK inhibitors canceled the increase of colonies.	Tetradecanoylphorbol Acetate	29-32	interleukin 6	Mus musculus	42-46
8077286-8	1994	TPA treatment, which induces partial differentiation of these cells, markedly increased TGF-beta 1 mRNA expression and growth factor release.	Tetradecanoylphorbol Acetate	0-3	transforming growth factor beta 1	Homo sapiens	88-98
7868057-3	1994	When colony numbers were compared with those supported by IL-3, IL-6+TPA gave rise to 86 + 47% of colonies formed with IL-3.	Tetradecanoylphorbol Acetate	69-72	interleukin 3	Mus musculus	58-62
7868057-3	1994	When colony numbers were compared with those supported by IL-3, IL-6+TPA gave rise to 86 + 47% of colonies formed with IL-3.	Tetradecanoylphorbol Acetate	69-72	interleukin 6	Mus musculus	64-68
7868057-3	1994	When colony numbers were compared with those supported by IL-3, IL-6+TPA gave rise to 86 + 47% of colonies formed with IL-3.	Tetradecanoylphorbol Acetate	69-72	interleukin 3	Mus musculus	119-123
7868057-6	1994	Delayed addition of IL-6 or TPA decreased colony numbers, suggesting that both IL-6 and TPA were needed from the start of cultures for maximal colony formation.	Tetradecanoylphorbol Acetate	88-91	interleukin 6	Mus musculus	20-24
7868057-9	1994	Chronic exposure of progenitors to TPA prior to the culture with IL-6+TPA suppressed colony formation.	Tetradecanoylphorbol Acetate	35-38	interleukin 6	Mus musculus	65-69
8083467-1	1994	Mouse thymoma line EL-4 cells produce cytokines such as interleukin (IL)-2, IL-3, IL-4, IL-10, and granulocyte-macrophage colony-stimulating factor in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	163-194	interleukin 10	Mus musculus	88-93
8077290-6	1994	The results indicate that both OAG and PMA dose dependently enhance f-Met-Leu-Phe (fMLP)-stimulated release of [3H]arachidonate.	Tetradecanoylphorbol Acetate	39-42	formyl peptide receptor 1	Homo sapiens	83-87
8077290-7	1994	Optimal concentrations of OAG (5 microns) and PMA (10 nM) are equipotent in increasing fMLP-stimulated arachidonate mobilization as quantitated either with total radioactivity or by mass measurements of free arachidonate.	Tetradecanoylphorbol Acetate	46-49	formyl peptide receptor 1	Homo sapiens	87-91
8077290-8	1994	By contrast OAG is sixfold more effective than PMA in enhancing synthesis of 5-lipoxygenase (5-LO) metabolites by mass and two to threefold more effective than PMA in enhancing synthesis of [3H]eicosanoids.	Tetradecanoylphorbol Acetate	47-50	arachidonate 5-lipoxygenase	Homo sapiens	77-91
8077286-9	1994	The majority of TGF-beta 1 secreted by TPA-treated cells was in its latent form.	Tetradecanoylphorbol Acetate	39-42	transforming growth factor beta 1	Homo sapiens	16-26
8077286-10	1994	However, anti-TGF-beta antibodies inhibited TGF-beta 1 and TPA-induced growth inhibition, calcitonin responsiveness, and TRAcP activity, suggesting that the TPA effect is mediated in part by autocrine TGF-beta 1 and indicating that the cells can activate and respond to the TGF-beta that they secrete.	Tetradecanoylphorbol Acetate	59-62	transforming growth factor beta 1	Homo sapiens	14-22
8077286-10	1994	However, anti-TGF-beta antibodies inhibited TGF-beta 1 and TPA-induced growth inhibition, calcitonin responsiveness, and TRAcP activity, suggesting that the TPA effect is mediated in part by autocrine TGF-beta 1 and indicating that the cells can activate and respond to the TGF-beta that they secrete.	Tetradecanoylphorbol Acetate	59-62	transforming growth factor beta 1	Homo sapiens	201-211
8077286-10	1994	However, anti-TGF-beta antibodies inhibited TGF-beta 1 and TPA-induced growth inhibition, calcitonin responsiveness, and TRAcP activity, suggesting that the TPA effect is mediated in part by autocrine TGF-beta 1 and indicating that the cells can activate and respond to the TGF-beta that they secrete.	Tetradecanoylphorbol Acetate	157-160	transforming growth factor beta 1	Homo sapiens	14-22
8077286-10	1994	However, anti-TGF-beta antibodies inhibited TGF-beta 1 and TPA-induced growth inhibition, calcitonin responsiveness, and TRAcP activity, suggesting that the TPA effect is mediated in part by autocrine TGF-beta 1 and indicating that the cells can activate and respond to the TGF-beta that they secrete.	Tetradecanoylphorbol Acetate	157-160	transforming growth factor beta 1	Homo sapiens	44-54
8077286-10	1994	However, anti-TGF-beta antibodies inhibited TGF-beta 1 and TPA-induced growth inhibition, calcitonin responsiveness, and TRAcP activity, suggesting that the TPA effect is mediated in part by autocrine TGF-beta 1 and indicating that the cells can activate and respond to the TGF-beta that they secrete.	Tetradecanoylphorbol Acetate	157-160	transforming growth factor beta 1	Homo sapiens	201-211
8077286-10	1994	However, anti-TGF-beta antibodies inhibited TGF-beta 1 and TPA-induced growth inhibition, calcitonin responsiveness, and TRAcP activity, suggesting that the TPA effect is mediated in part by autocrine TGF-beta 1 and indicating that the cells can activate and respond to the TGF-beta that they secrete.	Tetradecanoylphorbol Acetate	157-160	transforming growth factor beta 1	Homo sapiens	44-52
7996789-4	1994	The protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased HB-EGF mRNA levels by 15-fold in mesangial cells, and this induction of HB-EGF mRNA by TPA was both time- and dose-dependent.	Tetradecanoylphorbol Acetate	31-67	heparin-binding EGF-like growth factor	Rattus norvegicus	84-90
7519668-9	1994	Indeed, phorbol 12-myristate 13-acetate, a protein kinase C activator, also evoked IL-6 release from the U373MG cells.	Tetradecanoylphorbol Acetate	8-39	interleukin 6	Homo sapiens	83-87
7522595-4	1994	Phorbol 12-myristate 13-acetate pretreatment for 30 s caused an increase in the angiotensin II-induced rise in cytosolic calcium.	Tetradecanoylphorbol Acetate	0-31	angiotensinogen	Rattus norvegicus	80-94
7522595-5	1994	Although both captopril and verapamil reduced responses to angiotensin II to similar extents, only verapamil blocked the ability of phorbol 12-myristate 13-acetate to enhance responses to angiotensin II.	Tetradecanoylphorbol Acetate	132-163	angiotensinogen	Rattus norvegicus	188-202
7807524-7	1994	The addition of the tumor-promoting agent phorbol 12-myristate 13-acetate (TPA) led to an increased 32P phosphate incorporation into the Cx45 protein in transfected cells.	Tetradecanoylphorbol Acetate	42-73	gap junction protein gamma 1	Homo sapiens	137-141
7807524-7	1994	The addition of the tumor-promoting agent phorbol 12-myristate 13-acetate (TPA) led to an increased 32P phosphate incorporation into the Cx45 protein in transfected cells.	Tetradecanoylphorbol Acetate	75-78	gap junction protein gamma 1	Homo sapiens	137-141
7812673-4	1994	Oral administration of LTB4 receptor antagonists either as a pre-treatment or post-treatment attenuated TPA-induced edema and influx of neutrophils.	Tetradecanoylphorbol Acetate	104-107	leukotriene B4 receptor 1	Mus musculus	23-36
7996789-4	1994	The protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased HB-EGF mRNA levels by 15-fold in mesangial cells, and this induction of HB-EGF mRNA by TPA was both time- and dose-dependent.	Tetradecanoylphorbol Acetate	31-67	heparin-binding EGF-like growth factor	Rattus norvegicus	156-162
7996789-4	1994	The protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased HB-EGF mRNA levels by 15-fold in mesangial cells, and this induction of HB-EGF mRNA by TPA was both time- and dose-dependent.	Tetradecanoylphorbol Acetate	69-72	heparin-binding EGF-like growth factor	Rattus norvegicus	84-90
7996789-4	1994	The protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased HB-EGF mRNA levels by 15-fold in mesangial cells, and this induction of HB-EGF mRNA by TPA was both time- and dose-dependent.	Tetradecanoylphorbol Acetate	69-72	heparin-binding EGF-like growth factor	Rattus norvegicus	156-162
7996789-4	1994	The protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased HB-EGF mRNA levels by 15-fold in mesangial cells, and this induction of HB-EGF mRNA by TPA was both time- and dose-dependent.	Tetradecanoylphorbol Acetate	171-174	heparin-binding EGF-like growth factor	Rattus norvegicus	156-162
7996789-6	1994	Staurosporine, a protein kinase C inhibitor, abolished the induction of HB-EGF mRNA by TPA and serum.	Tetradecanoylphorbol Acetate	87-90	heparin-binding EGF-like growth factor	Rattus norvegicus	72-78
7935319-5	1994	In contrast to the desensitization observed with agonists, phorbol-12-myristate-13-acetate induces a sustained stimulation of PLD.	Tetradecanoylphorbol Acetate	59-90	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	126-129
8074672-1	1994	The purified preparation showed typical characteristics of the conventional type of mammalian PKC that responds to Ca2+, phosphatidylserine, and diacylglycerol or the tumor-promoting phorbol ester, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	198-229	proline rich transmembrane protein 2	Homo sapiens	94-97
7935319-6	1994	In addition, cells pretreated with carbachol or thrombin show a normal response to phorbol-12-myristate-13-acetate, suggesting that the enzymatic activity of PLD is not compromised.	Tetradecanoylphorbol Acetate	83-114	coagulation factor II, thrombin	Homo sapiens	48-56
8063804-3	1994	Earlier, we demonstrated that in normal human FS-4 fibroblasts, collagenase and stromelysin mRNA levels are increased not only after treatment with known matrix metalloproteinase inducers such as tumor necrosis factor (TNF), interleukin-1, and 12-O-tetradecanoylphorbol-13-acetate, but also with interferon-beta (IFN-beta).	Tetradecanoylphorbol Acetate	244-280	tumor necrosis factor	Homo sapiens	196-217
7914891-7	1994	Differentiation of U937 cells by exposure to 12-O-tetradecanoyl phorbol-13-acetate abolishes response to IL-6 but not IFN-gamma.	Tetradecanoylphorbol Acetate	45-82	interleukin 6	Homo sapiens	105-109
7520867-4	1994	PTP-PEST is also phosphorylated on both Ser39 and Ser435 following treatment of intact HeLa cells with TPA, forskolin or isobutyl methyl xanthine (IBMX).	Tetradecanoylphorbol Acetate	103-106	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	0-8
8063765-10	1994	Furthermore, RA inhibited activator protein-1 binding to 12-O-tetradecanoylphorbol 13-acetate-response element (TRE) in the cells treated with TNF-alpha, suggesting that RA acts as a potent negative regulator for activator protein-1 binding activity to TRE in the osteoblastic cells.	Tetradecanoylphorbol Acetate	57-93	tumor necrosis factor	Mus musculus	143-152
8067997-3	1994	Stimulation of T-cells by agonistic anti-CD28 antibodies in conjunction with phorbol 12-myristate 13-acetate (PMA)- or TcR-derived signals induces the enhanced activation of the transcription factor NF-kappa B.	Tetradecanoylphorbol Acetate	77-108	nuclear factor kappa B subunit 1	Homo sapiens	199-209
8067997-3	1994	Stimulation of T-cells by agonistic anti-CD28 antibodies in conjunction with phorbol 12-myristate 13-acetate (PMA)- or TcR-derived signals induces the enhanced activation of the transcription factor NF-kappa B.	Tetradecanoylphorbol Acetate	110-113	nuclear factor kappa B subunit 1	Homo sapiens	199-209
7520867-6	1994	In addition, PTP-PEST immunoprecipitated from TPA-treated cells displayed significantly lower PTP activity than enzyme obtained from untreated cells.	Tetradecanoylphorbol Acetate	46-49	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	13-21
7520282-9	1994	The inhibitory effect of PMA may be mediated via induction of a suppressor of iNOS expression, since pretreatment with PMA reduced NO production after subsequent treatment with cytokines.	Tetradecanoylphorbol Acetate	25-28	nitric oxide synthase 2	Rattus norvegicus	78-82
8065917-4	1994	Here we show by in vivo footprinting using dimethylsulfate (DMS) that the GAS of the IRF-1 promoter, which also contains an overlapping putative NF-kappa B site, is occupied upon treatment with gamma-interferon (IFN gamma) but not with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	236-267	interferon regulatory factor 1	Homo sapiens	85-90
7520282-9	1994	The inhibitory effect of PMA may be mediated via induction of a suppressor of iNOS expression, since pretreatment with PMA reduced NO production after subsequent treatment with cytokines.	Tetradecanoylphorbol Acetate	119-122	nitric oxide synthase 2	Rattus norvegicus	78-82
8061056-1	1994	DNA topoisomerase I is phosphorylated after mitogenic stimulation of 3T3-L1 mouse fibroblasts by 12-O-tetradecanoylphorbol 13-acetate (TPA), a phorbol ester tumor promoter.	Tetradecanoylphorbol Acetate	97-133	topoisomerase (DNA) I	Mus musculus	0-19
8061056-1	1994	DNA topoisomerase I is phosphorylated after mitogenic stimulation of 3T3-L1 mouse fibroblasts by 12-O-tetradecanoylphorbol 13-acetate (TPA), a phorbol ester tumor promoter.	Tetradecanoylphorbol Acetate	135-138	topoisomerase (DNA) I	Mus musculus	0-19
8061056-4	1994	In addition, VT-1, a non-responsive genetic variant of 3T3-L1, and the DNA topoisomerase I inhibitor camptothecin were used to further study TPA-induced DNA topoisomerase I phosphorylation.	Tetradecanoylphorbol Acetate	141-144	topoisomerase (DNA) I	Mus musculus	153-172
8065917-4	1994	Here we show by in vivo footprinting using dimethylsulfate (DMS) that the GAS of the IRF-1 promoter, which also contains an overlapping putative NF-kappa B site, is occupied upon treatment with gamma-interferon (IFN gamma) but not with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	236-267	interferon gamma	Homo sapiens	212-221
8049080-6	1994	Exposure of FTEC with the PKC activator phorbol 12-myristate 13-acetate (PMA), failed to increase the release of mucin.	Tetradecanoylphorbol Acetate	40-71	protein kinase C alpha	Homo sapiens	26-29
7521138-2	1994	Unlike the response to bradykinin, C5a and tumor necrosis factor-alpha (TNF-alpha) previously reported (15), the PMA-induced increase in [Ca2+]i was predominantly dependent on extracellular calcium.	Tetradecanoylphorbol Acetate	113-116	tumor necrosis factor	Rattus norvegicus	72-81
8052599-5	1994	In this cell line, both insulin-stimulated accumulation of phosphatidylinositol 3,4,5-trisphosphate and the insulin-stimulated glucose uptake due to the translocation of GLUT1 glucose transporters were markedly impaired, whereas neither phorbol 12-myristate 13-acetate-stimulated glucose uptake nor the insulin-stimulated activation of RAS was impaired.	Tetradecanoylphorbol Acetate	237-268	insulin	Cricetulus griseus	24-31
8052599-5	1994	In this cell line, both insulin-stimulated accumulation of phosphatidylinositol 3,4,5-trisphosphate and the insulin-stimulated glucose uptake due to the translocation of GLUT1 glucose transporters were markedly impaired, whereas neither phorbol 12-myristate 13-acetate-stimulated glucose uptake nor the insulin-stimulated activation of RAS was impaired.	Tetradecanoylphorbol Acetate	237-268	insulin	Cricetulus griseus	108-115
8052599-5	1994	In this cell line, both insulin-stimulated accumulation of phosphatidylinositol 3,4,5-trisphosphate and the insulin-stimulated glucose uptake due to the translocation of GLUT1 glucose transporters were markedly impaired, whereas neither phorbol 12-myristate 13-acetate-stimulated glucose uptake nor the insulin-stimulated activation of RAS was impaired.	Tetradecanoylphorbol Acetate	237-268	solute carrier family 2, facilitated glucose transporter member 1	Cricetulus griseus	170-175
8052599-5	1994	In this cell line, both insulin-stimulated accumulation of phosphatidylinositol 3,4,5-trisphosphate and the insulin-stimulated glucose uptake due to the translocation of GLUT1 glucose transporters were markedly impaired, whereas neither phorbol 12-myristate 13-acetate-stimulated glucose uptake nor the insulin-stimulated activation of RAS was impaired.	Tetradecanoylphorbol Acetate	237-268	insulin	Cricetulus griseus	108-115
7915087-4	1994	In THP-1 macrophages, histamine inhibited 4 beta-phorbol 12-myristate 13-acetate (PMA)-induced H2O2 formation via the activation of H2 receptors.	Tetradecanoylphorbol Acetate	44-80	GLI family zinc finger 2	Homo sapiens	3-8
7915087-4	1994	In THP-1 macrophages, histamine inhibited 4 beta-phorbol 12-myristate 13-acetate (PMA)-induced H2O2 formation via the activation of H2 receptors.	Tetradecanoylphorbol Acetate	82-85	GLI family zinc finger 2	Homo sapiens	3-8
8049080-8	1994	PMA also induced the translocation of PKC activity from the cytosol to the membrane fraction, which was still present after 15 min of exposure.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	38-41
7987254-1	1994	Whereas direct activation of protein kinase C (PKC) by the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) increased the subsequent binding of 125I-labelled angiotensin II (125I-AII; 0.5 nM) to RIE-1 cells, ligand-mediated activation of the kinase via angiotensin II (AII), which activates the phosphoinositide (PI) pathway in these cells, had no effect.	Tetradecanoylphorbol Acetate	74-111	angiotensinogen	Rattus norvegicus	168-182
7993666-1	1994	In the present study, we investigated the effects of different diacylglycerols in comparison with phorbol 12-myristate 13-acetate (PMA) on eicosanoid-independent phospholipase A2 (PLA2) activation in human platelets and neutrophils.	Tetradecanoylphorbol Acetate	131-134	phospholipase A2 group IB	Homo sapiens	162-178
7987254-1	1994	Whereas direct activation of protein kinase C (PKC) by the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) increased the subsequent binding of 125I-labelled angiotensin II (125I-AII; 0.5 nM) to RIE-1 cells, ligand-mediated activation of the kinase via angiotensin II (AII), which activates the phosphoinositide (PI) pathway in these cells, had no effect.	Tetradecanoylphorbol Acetate	74-111	angiotensinogen	Rattus norvegicus	263-277
7993666-1	1994	In the present study, we investigated the effects of different diacylglycerols in comparison with phorbol 12-myristate 13-acetate (PMA) on eicosanoid-independent phospholipase A2 (PLA2) activation in human platelets and neutrophils.	Tetradecanoylphorbol Acetate	131-134	phospholipase A2 group IB	Homo sapiens	180-184
7987254-1	1994	Whereas direct activation of protein kinase C (PKC) by the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) increased the subsequent binding of 125I-labelled angiotensin II (125I-AII; 0.5 nM) to RIE-1 cells, ligand-mediated activation of the kinase via angiotensin II (AII), which activates the phosphoinositide (PI) pathway in these cells, had no effect.	Tetradecanoylphorbol Acetate	113-116	angiotensinogen	Rattus norvegicus	168-182
7987254-1	1994	Whereas direct activation of protein kinase C (PKC) by the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) increased the subsequent binding of 125I-labelled angiotensin II (125I-AII; 0.5 nM) to RIE-1 cells, ligand-mediated activation of the kinase via angiotensin II (AII), which activates the phosphoinositide (PI) pathway in these cells, had no effect.	Tetradecanoylphorbol Acetate	113-116	angiotensinogen	Rattus norvegicus	263-277
7820874-9	1994	In addition, when the cells were cultured beyond confluence in the presence of TPA, spontaneous membrane ruffling was induced continuously up to termination of culture in TR4 but not in parent and TR5 cells.	Tetradecanoylphorbol Acetate	79-82	nuclear receptor subfamily 2, group C, member 2	Mus musculus	171-174
7820874-10	1994	These results suggest that the deficiency in cell contact-mediated inhibition of membrane ruffling may be responsible for hypersensitivity of TR4 cells to TPA-induced cell transformation.	Tetradecanoylphorbol Acetate	155-158	nuclear receptor subfamily 2, group C, member 2	Mus musculus	142-145
7519620-13	1994	Also other activators of beta 2 integrins such as phorbol-12-myristate 13-acetate (PMA), and formyl methionyl-leucyl-phenylalanine (FMLP), induced activation of p58fgr kinase activity.	Tetradecanoylphorbol Acetate	50-81	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	161-167
8050501-3	1994	We observed that u-PA and u-PA-ATF stimulated chemotactic migration of both LB6 clone 19 cells and human fibroblasts, which could be impaired by down-regulation of protein kinase C (PKC) with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	192-217	plasminogen activator, urokinase	Homo sapiens	17-21
8050501-3	1994	We observed that u-PA and u-PA-ATF stimulated chemotactic migration of both LB6 clone 19 cells and human fibroblasts, which could be impaired by down-regulation of protein kinase C (PKC) with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	192-217	plasminogen activator, urokinase	Homo sapiens	26-34
8045498-5	1994	Interleukin-1 beta and phorbol myristate acetate were also shown to induce in a dose-dependent fashion a threefold to fivefold increase of interleukin-6 production as measured by enzyme-linked immunosorbent assay in human primary biliary duct epithelium cultures, when compared with hepatocyte growth factor, epidermal growth factor, insulin-like growth factor, phytohemagglutinin, tumor necrosis factor-alpha or platelet-derived growth factor.	Tetradecanoylphorbol Acetate	23-48	interleukin 6	Homo sapiens	139-152
7835929-5	1994	Expression of CD43 on HMC-1 was down-regulated after stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	70-95	sialophorin	Homo sapiens	14-18
7835929-5	1994	Expression of CD43 on HMC-1 was down-regulated after stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	97-100	sialophorin	Homo sapiens	14-18
21559581-1	1994	The steady-state level and translocation of the protein kinase C (PKC) isozymes during the early stages of phorbol 12-myristate 13-acetate (PMA)-induced differentiation, was followed in AGF cells by Western blot analysis of various cell fractions, immunofluorescence staining and by confocal microscopy.	Tetradecanoylphorbol Acetate	107-138	protein kinase C alpha	Homo sapiens	66-69
21559581-1	1994	The steady-state level and translocation of the protein kinase C (PKC) isozymes during the early stages of phorbol 12-myristate 13-acetate (PMA)-induced differentiation, was followed in AGF cells by Western blot analysis of various cell fractions, immunofluorescence staining and by confocal microscopy.	Tetradecanoylphorbol Acetate	140-143	protein kinase C alpha	Homo sapiens	66-69
21559581-5	1994	Following stimulation with PMA from 15 min to 24 h, cytosolic PKC-alpha did not translocate to the membrane or nuclear fractions.	Tetradecanoylphorbol Acetate	27-30	protein kinase C alpha	Homo sapiens	62-71
7519620-13	1994	Also other activators of beta 2 integrins such as phorbol-12-myristate 13-acetate (PMA), and formyl methionyl-leucyl-phenylalanine (FMLP), induced activation of p58fgr kinase activity.	Tetradecanoylphorbol Acetate	83-86	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	161-167
8027566-2	1994	Fibronectin, collagen type IV, and laminin promoted haptotactic and chemotactic migration of lymphoid T cell lines and 12-O-tetradecanoylphorbol 13-acetate-stimulated blood lymphocytes, as determined using a modified Boyden chamber system.	Tetradecanoylphorbol Acetate	119-155	fibronectin 1	Homo sapiens	0-11
7527452-5	1994	Overnight treatment of ANA-1 cells with 100 ng/ml 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) caused the suppression of both PKC activity and LPL-induced TNF alpha mRNA expression.	Tetradecanoylphorbol Acetate	101-104	tumor necrosis factor	Mus musculus	166-175
8045973-6	1994	Northern analysis demonstrated specific messenger ribonucleic acid for pro-MMP-1 and pro-MMP-3 in phorbol myristate acetate-stimulated stromal cells.	Tetradecanoylphorbol Acetate	98-123	matrix metallopeptidase 3	Homo sapiens	89-94
8035171-6	1994	An analysis of the effects of IL-1 and TPA on immediate early gene expression indicated that IL-1 preferentially induced c-jun gene expression, whereas TPA greatly increased c-fos and zif/268 gene expression.	Tetradecanoylphorbol Acetate	152-155	early growth response 1	Rattus norvegicus	184-191
8035171-2	1994	Treatment of astrocytes with interleukin-1 beta (IL-1) or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased NGF mRNA content by six- to 10-fold, followed in time by increases in cell content and cell secretion of NGF.	Tetradecanoylphorbol Acetate	133-136	interleukin 1 beta	Rattus norvegicus	29-47
8068182-13	1994	Furthermore, treatment with TPA specifically increased the relative phosphorylation of PLC-gamma 1 in v-Ha-ras keratinocytes but not in normal keratinocytes.	Tetradecanoylphorbol Acetate	28-31	phospholipase C gamma 1	Homo sapiens	87-98
8035813-3	1994	NF-kappa B p50/p65 is the major inducible nuclear complex after lipopolysaccharide or phorbol myristate acetate treatment of 70Z/3 cells.	Tetradecanoylphorbol Acetate	86-111	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-10
8035813-3	1994	NF-kappa B p50/p65 is the major inducible nuclear complex after lipopolysaccharide or phorbol myristate acetate treatment of 70Z/3 cells.	Tetradecanoylphorbol Acetate	86-111	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	11-14
8068183-5	1994	TPA induced the appearance of a fourth connexin 43-immunoreactive band (P3) and a concomitant decrease in the relative intensity of the unphosphorylated (P0) band within 5 min of treatment.	Tetradecanoylphorbol Acetate	0-3	gap junction protein, alpha 1	Rattus norvegicus	39-50
8034686-2	1994	IL-6 expression is induced in young human diploid fibroblasts (HDF) in response to a number of agents including fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate, double-stranded RNA, and forskolin.	Tetradecanoylphorbol Acetate	132-168	interleukin 6	Homo sapiens	0-4
7970940-5	1994	Furthermore, IgA had a dose-dependent inhibitory effect on the receptor-independent induction of the respiratory burst, as examined by flow cytometry in monocytes and granulocytes activated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	195-220	CD79a molecule	Homo sapiens	13-16
8034626-6	1994	No effects of the Rap1A mutants on cell viability, proliferation, expression of cell-surface markers, or phorbol 12-myristate 13-acetate-stimulated interleukin-8 generation were detected.	Tetradecanoylphorbol Acetate	105-136	C-X-C motif chemokine ligand 8	Homo sapiens	148-161
8034717-5	1994	Inhibition of PKC with the inhibitor, bisindolylmaleimide (GF109203X), or by prolonged exposure to PMA suppressed both arachidonic acid release and MAP kinase activation in PMA- and zymosan-stimulated macrophages but not in okadaic acid or A23187-treated cells.	Tetradecanoylphorbol Acetate	173-176	proline rich transmembrane protein 2	Homo sapiens	14-17
8034717-7	1994	This approach was complicated since initial exposure to PMA to down-regulate PKC increased cytosolic PLA2 activity which remained elevated for 16 h. In contrast, GF109203X treatment suppressed the increase in cytosolic PLA2 activity in response to zymosan and PMA but not to okadaic acid or A23187.	Tetradecanoylphorbol Acetate	56-59	proline rich transmembrane protein 2	Homo sapiens	77-80
8048072-3	1994	When supernatants of cells stimulated with phorbol 12-myristate 13-acetate (PMA) were assessed by enzyme-linked immunosorbent assay, IL-2, 4, and 5 were increased in the presence of 50 and/or 100 ng/ml VT for 2 and/or 8 days of culture.	Tetradecanoylphorbol Acetate	43-74	interleukin 24	Mus musculus	133-140
8048072-3	1994	When supernatants of cells stimulated with phorbol 12-myristate 13-acetate (PMA) were assessed by enzyme-linked immunosorbent assay, IL-2, 4, and 5 were increased in the presence of 50 and/or 100 ng/ml VT for 2 and/or 8 days of culture.	Tetradecanoylphorbol Acetate	76-79	interleukin 24	Mus musculus	133-140
8034717-7	1994	This approach was complicated since initial exposure to PMA to down-regulate PKC increased cytosolic PLA2 activity which remained elevated for 16 h. In contrast, GF109203X treatment suppressed the increase in cytosolic PLA2 activity in response to zymosan and PMA but not to okadaic acid or A23187.	Tetradecanoylphorbol Acetate	56-59	phospholipase A2 group IB	Homo sapiens	101-105
8034686-3	1994	In contrast, we find that senescent HDF are markedly deficient in their ability to express IL-6 in response to serum, double-stranded RNA, and 12-O-tetradecanoyl-phorbol-13-acetate, whereas forskolin is still an effective inducer for senescent cells.	Tetradecanoylphorbol Acetate	143-180	interleukin 6	Homo sapiens	91-95
8034717-7	1994	This approach was complicated since initial exposure to PMA to down-regulate PKC increased cytosolic PLA2 activity which remained elevated for 16 h. In contrast, GF109203X treatment suppressed the increase in cytosolic PLA2 activity in response to zymosan and PMA but not to okadaic acid or A23187.	Tetradecanoylphorbol Acetate	260-263	phospholipase A2 group IB	Homo sapiens	219-223
8034717-9	1994	In addition, the results are consistent with a role for MAP kinase activation in regulating the activation of the 85-kDa PLA2 and arachidonic acid release in PMA-, zymosan-, and okadaic acid-stimulated cells, whereas these responses in A23187-treated cells are MAP kinase-and PKC-independent.	Tetradecanoylphorbol Acetate	158-161	phospholipase A2 group IB	Homo sapiens	121-125
8038214-12	1994	This observation is consistent with a small (3-fold) increase in PTH-induced cAMP release as a result of PMA pre-treatment.	Tetradecanoylphorbol Acetate	105-108	parathyroid hormone	Homo sapiens	65-68
8034717-9	1994	In addition, the results are consistent with a role for MAP kinase activation in regulating the activation of the 85-kDa PLA2 and arachidonic acid release in PMA-, zymosan-, and okadaic acid-stimulated cells, whereas these responses in A23187-treated cells are MAP kinase-and PKC-independent.	Tetradecanoylphorbol Acetate	158-161	proline rich transmembrane protein 2	Homo sapiens	276-279
7913409-3	1994	On stimulation with phytohemagglutinin and phorbol 12-myristate 13-acetate, transplant-derived peripheral blood mononuclear cells demonstrate statistically significant depressed production of interleukin 3 (IL-3), IL-4, granulocyte-macrophage-colony-stimulating factor, and gamma-interferon as compared to normal controls, during the first 6 months following engraftment, which recover to normal levels 6 months or more posttransplant.	Tetradecanoylphorbol Acetate	43-74	interleukin 4	Homo sapiens	214-218
7519011-7	1994	Similarly, the increase in [Ca2+]i produced by fMLP but not that produced by maitotoxin was inhibited by pretreatment with phorbol myristate acetate (100 ng/ml).	Tetradecanoylphorbol Acetate	123-148	formyl peptide receptor 1	Homo sapiens	47-51
8034037-2	1994	We show that a binding sequence for the transcription factor IRF-1 is contained in the first intron of the human ODC gene (from nt +2711 to nt +2722) and we demonstrate that the level of expression of IRF-1 increases in human macrophages and in the human promonocytic cell line, U937, previously differentiated in monocytes/macrophages by phorbol myristate acetate (PMA), after 2 h of IFN gamma stimulation.	Tetradecanoylphorbol Acetate	339-364	interferon regulatory factor 1	Homo sapiens	61-66
7517419-0	1994	TNF-alpha associated with fibronectin enhances phorbol myristate acetate- or antigen-mediated integrin-dependent adhesion of CD4+ T cells via protein tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	47-72	tumor necrosis factor	Rattus norvegicus	0-9
7517419-4	1994	A brief exposure of CD4+ cells to low dosages of soluble TNF-alpha or of FN- or laminin-bound TNF-alpha synergized with PMA to enhance the integrin-mediated binding of CD4+ cells to these immobilized ECM moieties.	Tetradecanoylphorbol Acetate	120-123	tumor necrosis factor	Rattus norvegicus	57-66
7517419-4	1994	A brief exposure of CD4+ cells to low dosages of soluble TNF-alpha or of FN- or laminin-bound TNF-alpha synergized with PMA to enhance the integrin-mediated binding of CD4+ cells to these immobilized ECM moieties.	Tetradecanoylphorbol Acetate	120-123	tumor necrosis factor	Rattus norvegicus	94-103
7517419-5	1994	TNF-alpha-enhanced adhesion of CD4+ cells did not delay or inhibit the subsequent detachment of the cells from the substrate, and adhesion was increased provided the cells were treated with TNF-alpha immediately after their exposure to PMA.	Tetradecanoylphorbol Acetate	236-239	tumor necrosis factor	Rattus norvegicus	0-9
7517419-5	1994	TNF-alpha-enhanced adhesion of CD4+ cells did not delay or inhibit the subsequent detachment of the cells from the substrate, and adhesion was increased provided the cells were treated with TNF-alpha immediately after their exposure to PMA.	Tetradecanoylphorbol Acetate	236-239	tumor necrosis factor	Rattus norvegicus	190-199
7517419-8	1994	Soluble, and to a greater extent FN-bound, TNF-alpha synergizes with PMA to intensify protein tyrosine phosphorylation in FN-bound CD4+ cells, and this effect of TNF-alpha was inhibited by inhibitors of tyrosine kinase.	Tetradecanoylphorbol Acetate	69-72	tumor necrosis factor	Rattus norvegicus	162-171
8034037-2	1994	We show that a binding sequence for the transcription factor IRF-1 is contained in the first intron of the human ODC gene (from nt +2711 to nt +2722) and we demonstrate that the level of expression of IRF-1 increases in human macrophages and in the human promonocytic cell line, U937, previously differentiated in monocytes/macrophages by phorbol myristate acetate (PMA), after 2 h of IFN gamma stimulation.	Tetradecanoylphorbol Acetate	339-364	interferon regulatory factor 1	Homo sapiens	201-206
8013086-5	1994	The protein kinase C activators (12-O-tetradecanoylphorbol 13-acetate [TPA], phorbol 12,13-dibutyrate, and 1-oleyl-2-acetyl-rac-glycerol) induced c-fos mRNA expression, which was also potentiated by TGF-beta 1.	Tetradecanoylphorbol Acetate	33-69	transforming growth factor, beta 1	Rattus norvegicus	199-209
8043027-1	1994	Bradykinin (BK) evoked [3H]noradrenaline ([3H]NA) release from the human neuroblastoma SH-SY5Y and this was enhanced by pre-treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) for 8 min.	Tetradecanoylphorbol Acetate	139-175	kininogen 1	Homo sapiens	0-10
8043027-1	1994	Bradykinin (BK) evoked [3H]noradrenaline ([3H]NA) release from the human neuroblastoma SH-SY5Y and this was enhanced by pre-treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) for 8 min.	Tetradecanoylphorbol Acetate	139-175	kininogen 1	Homo sapiens	12-14
8043027-1	1994	Bradykinin (BK) evoked [3H]noradrenaline ([3H]NA) release from the human neuroblastoma SH-SY5Y and this was enhanced by pre-treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) for 8 min.	Tetradecanoylphorbol Acetate	177-180	kininogen 1	Homo sapiens	0-10
8043027-1	1994	Bradykinin (BK) evoked [3H]noradrenaline ([3H]NA) release from the human neuroblastoma SH-SY5Y and this was enhanced by pre-treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) for 8 min.	Tetradecanoylphorbol Acetate	177-180	kininogen 1	Homo sapiens	12-14
8043027-6	1994	Although pre-treatment of SH-SY5Y cells with TPA enhanced BK-evoked [3H]NA release, the elevation of intracellular calcium [Ca2+]; was decreased by about 50%.	Tetradecanoylphorbol Acetate	45-48	kininogen 1	Homo sapiens	58-60
7517209-6	1994	In addition, supernatants of purified B-CLL cells cultured in the presence of 12-O-tetradecanoylphorbol-13-acetate showed chemotactic activity towards neutrophils; this activity was neutralized in the presence of an anti-IL-8 antiserum.	Tetradecanoylphorbol Acetate	78-114	C-X-C motif chemokine ligand 8	Homo sapiens	221-225
8026583-1	1994	Addition of 12-O-tetradecanoylphorbol-13-acetate to RIE-1 rat intestinal epithelial cells stimulated a rapid (mean 3-fold) increase in the subsequent binding of 125I-labelled angiotensin II which was reversed or prevented when cellular protein kinase C was depleted.	Tetradecanoylphorbol Acetate	12-48	angiotensinogen	Rattus norvegicus	175-189
8048538-6	1994	The mRNAs and cellular growth hormone protein generated from the chimeric TKGH(SP-B2.0) and TKGH(SP-B.837) genes were each inhibited by approximately 50% by TPA and TNF-alpha.	Tetradecanoylphorbol Acetate	157-160	growth hormone 1	Homo sapiens	23-37
7948741-4	1994	Following phytohemagglutinin (PHA)/4 beta-phorbol 12-myristate 13 acetate (TPA) stimulation, a 14 kDa molecule could be visualized in Western blots by means of two monoclonal anti-IL-2 antibodies possessing different epitope specificities.	Tetradecanoylphorbol Acetate	37-73	interleukin 2	Homo sapiens	180-184
7947460-2	1994	We have previously reported that allergen-specific CD4+ Th2 T cell clones produce IFN-gamma, following activation by phorbol ester (TPA) and calcium ionophore, indicating that these cells still have the ability to produce IFN-gamma.	Tetradecanoylphorbol Acetate	132-135	CD4 molecule	Homo sapiens	51-54
7948741-4	1994	Following phytohemagglutinin (PHA)/4 beta-phorbol 12-myristate 13 acetate (TPA) stimulation, a 14 kDa molecule could be visualized in Western blots by means of two monoclonal anti-IL-2 antibodies possessing different epitope specificities.	Tetradecanoylphorbol Acetate	75-78	interleukin 2	Homo sapiens	180-184
7534576-8	1994	K16 was only present in post-mitotic cells and was transiently expressed 8-72 h after TPA treatment.	Tetradecanoylphorbol Acetate	86-89	keratin 16	Mus musculus	0-3
8013344-10	1994	These inhibitory effects were mimicked by phorbol 12-myristate 13-acetate, an activator of protein kinase-C, suggesting that ET-1 action on Sertoli cells might be linked to the protein kinase-C pathway.	Tetradecanoylphorbol Acetate	42-73	endothelin 1	Rattus norvegicus	125-129
7947460-2	1994	We have previously reported that allergen-specific CD4+ Th2 T cell clones produce IFN-gamma, following activation by phorbol ester (TPA) and calcium ionophore, indicating that these cells still have the ability to produce IFN-gamma.	Tetradecanoylphorbol Acetate	132-135	interferon gamma	Homo sapiens	82-91
7947460-4	1994	Activation with antigen or TPA/anti-CD3 mAb of Th2 T cell clones that had been preincubated with rIL-12 and rIL-2 for 5 days induced or enhanced the expression of IFN-gamma transcripts, as well as the production of IFN-gamma by these cells.	Tetradecanoylphorbol Acetate	27-30	interferon gamma	Homo sapiens	163-172
7947460-4	1994	Activation with antigen or TPA/anti-CD3 mAb of Th2 T cell clones that had been preincubated with rIL-12 and rIL-2 for 5 days induced or enhanced the expression of IFN-gamma transcripts, as well as the production of IFN-gamma by these cells.	Tetradecanoylphorbol Acetate	27-30	interferon gamma	Homo sapiens	215-224
7517981-5	1994	In regard to FK-506, we found that 1) FK-506 completely blocked the production of IL-2; 2) exogeneous IL-2 consistently restored the FK-506-induced inhibition; 3) FK-506 affected the phorbol myristate acetate-induced IL-2 responsiveness very little, if any; and 4) the significant suppression was observed only when FK-506 was added within 24 h after the initiation of culture.	Tetradecanoylphorbol Acetate	183-208	interleukin 2	Homo sapiens	102-106
7983166-4	1994	These included: (i) a dramatic decrease in the expression of cyclin A, cyclin B and cdk2, and surprisingly an up-regulation of cyclin D1 in TPA-induced macrophage-like cells; (ii) a down-regulation of cyclin E in retinoic acid-induced granulocytic cells; and (iii) a decreased abundance of cyclin D1 and D2, but high levels of cyclin A, B and E RNA in DMSO-induced granulocytic cells.	Tetradecanoylphorbol Acetate	140-143	cyclin A2	Homo sapiens	327-335
7517981-5	1994	In regard to FK-506, we found that 1) FK-506 completely blocked the production of IL-2; 2) exogeneous IL-2 consistently restored the FK-506-induced inhibition; 3) FK-506 affected the phorbol myristate acetate-induced IL-2 responsiveness very little, if any; and 4) the significant suppression was observed only when FK-506 was added within 24 h after the initiation of culture.	Tetradecanoylphorbol Acetate	183-208	interleukin 2	Homo sapiens	102-106
7515932-6	1994	Treatment of CD4 wild-type transfected cells with either anti-CD45 mAb, EGTA, or PMA rapidly restored the cells to basal levels of intracellular calcium.	Tetradecanoylphorbol Acetate	81-84	CD4 molecule	Homo sapiens	13-16
8207793-3	1994	Transient expression of HIV-1 Tat induced a five- to eightfold increase in IL-2 promoter activity in Jurkat T cells stimulated with phytohemagglutinin and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	155-180	interleukin 2	Homo sapiens	75-79
7932876-2	1994	In this system, NPY production increases progressively with culture-age and it is induced by forskolin (FOR) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	113-144	neuropeptide Y	Rattus norvegicus	16-19
7932876-2	1994	In this system, NPY production increases progressively with culture-age and it is induced by forskolin (FOR) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	146-149	neuropeptide Y	Rattus norvegicus	16-19
7516333-7	1994	Pretreatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA) abrogated thrombin receptor [Ca2+]i signaling, and TRAP-induced Ca2+ entry was inhibited by the acute treatment with PMA.	Tetradecanoylphorbol Acetate	36-67	coagulation factor II, thrombin	Homo sapiens	84-92
7912755-6	1994	On liquid culture with or without 5 x 10(-9) M 12-O-tetradecanoylphorbol-13-acetate (TPA) for 3 days, the blasts formed aggregates of proliferating and elongating cells on the wall of the flasks with a decline in CD34, numerous dendritic processes appeared on the cells and there was strong positivity for ATPase/ADPase, but no other changes in phenotype.	Tetradecanoylphorbol Acetate	47-83	CD34 molecule	Homo sapiens	213-217
7912755-6	1994	On liquid culture with or without 5 x 10(-9) M 12-O-tetradecanoylphorbol-13-acetate (TPA) for 3 days, the blasts formed aggregates of proliferating and elongating cells on the wall of the flasks with a decline in CD34, numerous dendritic processes appeared on the cells and there was strong positivity for ATPase/ADPase, but no other changes in phenotype.	Tetradecanoylphorbol Acetate	85-88	CD34 molecule	Homo sapiens	213-217
7912755-10	1994	Culture supernatants from blasts cultured with or without TPA showed the production of large amounts of IL-8, IL-6, TNF-alpha, MIP-1 alpha, IL-10 and interferon gamma and modest amounts of IL-1 alpha, GM-CSF and stem cell factor.	Tetradecanoylphorbol Acetate	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
7912755-10	1994	Culture supernatants from blasts cultured with or without TPA showed the production of large amounts of IL-8, IL-6, TNF-alpha, MIP-1 alpha, IL-10 and interferon gamma and modest amounts of IL-1 alpha, GM-CSF and stem cell factor.	Tetradecanoylphorbol Acetate	58-61	interleukin 6	Homo sapiens	110-114
7912755-10	1994	Culture supernatants from blasts cultured with or without TPA showed the production of large amounts of IL-8, IL-6, TNF-alpha, MIP-1 alpha, IL-10 and interferon gamma and modest amounts of IL-1 alpha, GM-CSF and stem cell factor.	Tetradecanoylphorbol Acetate	58-61	tumor necrosis factor	Homo sapiens	116-125
8031867-3	1994	The phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA) caused an acute redistribution of PKC-alpha to the nucleus, but did not change the distribution of PKC-zeta.	Tetradecanoylphorbol Acetate	19-56	protein kinase C alpha	Homo sapiens	97-106
8031867-3	1994	The phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA) caused an acute redistribution of PKC-alpha to the nucleus, but did not change the distribution of PKC-zeta.	Tetradecanoylphorbol Acetate	58-61	protein kinase C alpha	Homo sapiens	97-106
8031867-4	1994	Chronic treatment with TPA down-regulated total PKC-alpha, but not -zeta.	Tetradecanoylphorbol Acetate	23-26	protein kinase C alpha	Homo sapiens	48-57
8031867-6	1994	These studies demonstrate for the first time the constitutive expression and divergent responses to TPA of the Ca(2+)-dependent and Ca(2+)-independent isoforms of PKC in the nuclei of Caco-2 cells and suggest that these specific isoforms may be involved in modulating gene expression.	Tetradecanoylphorbol Acetate	100-103	protein kinase C alpha	Homo sapiens	163-166
8014008-11	1994	The presence of an elastase-like activity in detergent extracts and the ability of an elastase inhibitor to block the TPA-induced secretion of TGF-alpha suggests that PKC and an elastase-like enzyme are involved in the processing and secretion of TGF-alpha by human colon carcinoma cell lines.	Tetradecanoylphorbol Acetate	118-121	proline rich transmembrane protein 2	Homo sapiens	167-170
8208545-1	1994	FD/PMA, a derivative of the interleukin-3 (IL-3) dependent FDC-P1 cell line, proliferates in response to either phorbol esters (phorbol 12-myristate 13-acetate, PMA) or IL-3.	Tetradecanoylphorbol Acetate	3-6	interleukin 3	Mus musculus	28-41
8208545-1	1994	FD/PMA, a derivative of the interleukin-3 (IL-3) dependent FDC-P1 cell line, proliferates in response to either phorbol esters (phorbol 12-myristate 13-acetate, PMA) or IL-3.	Tetradecanoylphorbol Acetate	3-6	interleukin 3	Mus musculus	43-47
8208545-1	1994	FD/PMA, a derivative of the interleukin-3 (IL-3) dependent FDC-P1 cell line, proliferates in response to either phorbol esters (phorbol 12-myristate 13-acetate, PMA) or IL-3.	Tetradecanoylphorbol Acetate	3-6	interleukin 3	Mus musculus	169-173
7524893-4	1994	On the other hand, the expression of the IL-6 gene was markedly induced in all the lines by lipopolysaccharide (LPS) and by phorbol 12-myristate 13 acetate (PMA).	Tetradecanoylphorbol Acetate	124-155	interleukin 6	Mus musculus	41-45
7524893-4	1994	On the other hand, the expression of the IL-6 gene was markedly induced in all the lines by lipopolysaccharide (LPS) and by phorbol 12-myristate 13 acetate (PMA).	Tetradecanoylphorbol Acetate	157-160	interleukin 6	Mus musculus	41-45
8031867-0	1994	TPA causes divergent responses of Ca(2+)-dependent and Ca(2+)-independent isoforms of PKC in the nuclei of Caco-2 cells.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	86-89
7516333-7	1994	Pretreatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA) abrogated thrombin receptor [Ca2+]i signaling, and TRAP-induced Ca2+ entry was inhibited by the acute treatment with PMA.	Tetradecanoylphorbol Acetate	69-72	coagulation factor II, thrombin	Homo sapiens	84-92
7516337-5	1994	It was possible, however, to activate Raf-1, MEK-1, and p42MAPK in J.CaM1 cells during treatment with the phorbol ester phorbol 12-myristate 13-acetate, which activates protein kinase C (PKC).	Tetradecanoylphorbol Acetate	120-151	mitogen-activated protein kinase 1	Homo sapiens	56-63
7515882-4	1994	In these cells, TPA caused 32% stimulation of PP-1 activity.	Tetradecanoylphorbol Acetate	16-19	inorganic pyrophosphatase 1	Homo sapiens	46-50
8018731-3	1994	Further, we found that an 176 bp region between -623 to -447 was required for the induction of apolipoprotein E gene transcription during 12-O-tetradecanoylphorbol-13-acetate-induced differentiation of monocytes to macrophages.	Tetradecanoylphorbol Acetate	138-174	apolipoprotein E	Homo sapiens	95-111
8011674-3	1994	LPS-mediated PLD activation of THP-1 or U-937 was inhibited by staurosporine (2 microM) and by protein kinase C (PKC) down-regulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) suggesting a role for PKC.	Tetradecanoylphorbol Acetate	139-175	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	13-16
8011674-3	1994	LPS-mediated PLD activation of THP-1 or U-937 was inhibited by staurosporine (2 microM) and by protein kinase C (PKC) down-regulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) suggesting a role for PKC.	Tetradecanoylphorbol Acetate	139-175	GLI family zinc finger 2	Homo sapiens	31-36
8011674-3	1994	LPS-mediated PLD activation of THP-1 or U-937 was inhibited by staurosporine (2 microM) and by protein kinase C (PKC) down-regulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) suggesting a role for PKC.	Tetradecanoylphorbol Acetate	177-180	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	13-16
8011674-3	1994	LPS-mediated PLD activation of THP-1 or U-937 was inhibited by staurosporine (2 microM) and by protein kinase C (PKC) down-regulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) suggesting a role for PKC.	Tetradecanoylphorbol Acetate	177-180	GLI family zinc finger 2	Homo sapiens	31-36
7515882-5	1994	The PP-1 stimulation by TPA was comparable to stimulation by insulin (t1/2 = 1 min and EC50 = 5 nM) with a maximum effect in 5 min.	Tetradecanoylphorbol Acetate	24-27	inorganic pyrophosphatase 1	Homo sapiens	4-8
7515882-8	1994	ML-9, a myosin light chain kinase inhibitor, blocked the effects of insulin and TPA on both MAPK and PP-1 activation.	Tetradecanoylphorbol Acetate	80-83	inorganic pyrophosphatase 1	Homo sapiens	101-105
7515882-12	1994	These inhibitors completely prevented insulin and TPA stimulation of MAPK and PP-1 and blocked insulin-induced translocation of PKC to the plasma membranes.	Tetradecanoylphorbol Acetate	50-53	inorganic pyrophosphatase 1	Homo sapiens	78-82
8204888-3	1994	Tumor necrosis factor-alpha (TNF-alpha) enhanced the enzyme release threefold to fourfold and the protein kinase C (PKC) activator and differentiation inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) eightfold to ninefold.	Tetradecanoylphorbol Acetate	197-200	tumor necrosis factor	Homo sapiens	0-27
7518234-7	1994	Two different protein kinase C (PKC) activators TPA (200 nM) and bryostatin 1 (200 nM) similarly inhibited rhSCF- (22 and 32%, respectively) and anti-IgE-induced (24 and 32%) Ca2+ response.	Tetradecanoylphorbol Acetate	48-51	immunoglobulin heavy constant epsilon	Homo sapiens	150-153
8204888-3	1994	Tumor necrosis factor-alpha (TNF-alpha) enhanced the enzyme release threefold to fourfold and the protein kinase C (PKC) activator and differentiation inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) eightfold to ninefold.	Tetradecanoylphorbol Acetate	197-200	tumor necrosis factor	Homo sapiens	29-38
8204888-7	1994	Agents that inhibit TNF-alpha expression in HL-60 cells, such as pentoxifylline and dexamethasone, completely abrogated both the constitutive and TPA-evoked MMP-9 release.	Tetradecanoylphorbol Acetate	146-149	tumor necrosis factor	Homo sapiens	20-29
8204888-8	1994	Diethyldithiocarbamate, which is known to stimulate TNF-alpha production in HL-60 cells, exerted a positive effect on MMP-9 release in untreated cells but was inhibitory in TPA-treated HL-60 cells.	Tetradecanoylphorbol Acetate	173-176	tumor necrosis factor	Homo sapiens	52-61
7911467-8	1994	When PKC-alpha protein levels are depleted by oligonucleotide treatment of A549 cells, the increase in ICAM-1 expression in response to phorbol 12-myristate 13-acetate is greatly reduced, demonstrating that PKC-alpha plays a major role in this process.	Tetradecanoylphorbol Acetate	136-167	protein kinase C alpha	Homo sapiens	5-14
7911467-8	1994	When PKC-alpha protein levels are depleted by oligonucleotide treatment of A549 cells, the increase in ICAM-1 expression in response to phorbol 12-myristate 13-acetate is greatly reduced, demonstrating that PKC-alpha plays a major role in this process.	Tetradecanoylphorbol Acetate	136-167	protein kinase C alpha	Homo sapiens	207-216
8205621-1	1994	T lymphocyte activation and interleukin-2 (IL-2) production require at least two signals, generated by phorbol ester (TPA) and Ca2+ ionophore or costimulation of the T cell receptor (TCR) and the CD28 auxiliary receptor.	Tetradecanoylphorbol Acetate	118-121	interleukin 2	Homo sapiens	28-41
8195229-2	1994	Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	290-326	insulin	Homo sapiens	233-240
8195229-2	1994	Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	328-331	insulin	Homo sapiens	233-240
8205621-1	1994	T lymphocyte activation and interleukin-2 (IL-2) production require at least two signals, generated by phorbol ester (TPA) and Ca2+ ionophore or costimulation of the T cell receptor (TCR) and the CD28 auxiliary receptor.	Tetradecanoylphorbol Acetate	118-121	interleukin 2	Homo sapiens	43-47
8205621-3	1994	Full activation of the MAP kinases that phosphorylate the Jun activation domain, JNK1 and JNK2, required costimulation of T cells with either TPA and Ca2+ ionophore or antibodies to TCR and CD28.	Tetradecanoylphorbol Acetate	142-145	mitogen-activated protein kinase 8	Homo sapiens	81-85
8205621-3	1994	Full activation of the MAP kinases that phosphorylate the Jun activation domain, JNK1 and JNK2, required costimulation of T cells with either TPA and Ca2+ ionophore or antibodies to TCR and CD28.	Tetradecanoylphorbol Acetate	142-145	mitogen-activated protein kinase 9	Homo sapiens	90-94
8205621-6	1994	By contrast, the MAP kinases ERK1 and ERK2 were fully activated by TPA or TCR stimulation and were not affected by Ca2+, CD28, or CsA.	Tetradecanoylphorbol Acetate	67-70	mitogen-activated protein kinase 3	Homo sapiens	29-33
8205621-6	1994	By contrast, the MAP kinases ERK1 and ERK2 were fully activated by TPA or TCR stimulation and were not affected by Ca2+, CD28, or CsA.	Tetradecanoylphorbol Acetate	67-70	mitogen-activated protein kinase 1	Homo sapiens	38-42
8020150-0	1994	Two inhibitors of gap junctional intercellular communication, TPA and endosulfan: different effects on phosphorylation of connexin 43 in the rat liver epithelial cell line, IAR 20.	Tetradecanoylphorbol Acetate	62-65	gap junction protein, alpha 1	Rattus norvegicus	122-133
8023920-0	1994	Bidirectional modulation of parathyroid hormone-responsive adenylyl cyclase by protein kinase C. The temporal pattern with which phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), modulates parathyroid hormone (PTH)-responsive adenylyl cyclase (AC) was evaluated in a clonal osteoblast-like cell line (UMR-106).	Tetradecanoylphorbol Acetate	129-160	parathyroid hormone	Rattus norvegicus	28-47
8023920-0	1994	Bidirectional modulation of parathyroid hormone-responsive adenylyl cyclase by protein kinase C. The temporal pattern with which phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), modulates parathyroid hormone (PTH)-responsive adenylyl cyclase (AC) was evaluated in a clonal osteoblast-like cell line (UMR-106).	Tetradecanoylphorbol Acetate	162-165	parathyroid hormone	Rattus norvegicus	28-47
8023920-0	1994	Bidirectional modulation of parathyroid hormone-responsive adenylyl cyclase by protein kinase C. The temporal pattern with which phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), modulates parathyroid hormone (PTH)-responsive adenylyl cyclase (AC) was evaluated in a clonal osteoblast-like cell line (UMR-106).	Tetradecanoylphorbol Acetate	162-165	parathyroid hormone	Rattus norvegicus	218-237
8023920-0	1994	Bidirectional modulation of parathyroid hormone-responsive adenylyl cyclase by protein kinase C. The temporal pattern with which phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), modulates parathyroid hormone (PTH)-responsive adenylyl cyclase (AC) was evaluated in a clonal osteoblast-like cell line (UMR-106).	Tetradecanoylphorbol Acetate	162-165	parathyroid hormone	Rattus norvegicus	239-242
8023920-1	1994	Brief (&lt; or = 1 h) exposure of UMR-106 cells to PMA enhanced PTH stimulation of AC, whereas more prolonged PMA treatment decreased the PTH response, with maximum inhibition occurring at &lt; or = 6 h. PMA treatment also resulted in initial activation followed by downregulation of PKC.	Tetradecanoylphorbol Acetate	51-54	parathyroid hormone	Rattus norvegicus	64-67
8023920-1	1994	Brief (&lt; or = 1 h) exposure of UMR-106 cells to PMA enhanced PTH stimulation of AC, whereas more prolonged PMA treatment decreased the PTH response, with maximum inhibition occurring at &lt; or = 6 h. PMA treatment also resulted in initial activation followed by downregulation of PKC.	Tetradecanoylphorbol Acetate	110-113	parathyroid hormone	Rattus norvegicus	138-141
8086342-5	1994	Accordingly, we found that WT1 mRNA was down-regulated in K562 cells during induction of erythroid and megakaryocytic differentiation by sodium butyrate and 12-O-tetradecanoylphorbol-13-acetate, respectively.	Tetradecanoylphorbol Acetate	157-193	WT1 transcription factor	Homo sapiens	27-30
8086342-7	1994	WT1 mRNA was not down-regulated when 12-O-tetradecanoylphorbol-13-acetate-induced differentiation was blocked by bryostatin-1.	Tetradecanoylphorbol Acetate	37-73	WT1 transcription factor	Homo sapiens	0-3
8086342-8	1994	During 12-O-tetradecanoylphorbol-13-acetate treatment, the decrease in WT1 mRNA was rapid (within 5 min), continuous, and occurred, at least in part, posttranscriptionally.	Tetradecanoylphorbol Acetate	7-43	WT1 transcription factor	Homo sapiens	71-74
8199172-4	1994	mRNA expression of LRP was induced during cell differentiation from human monocytes to macrophages or after incubation with phorbol ester (tetradecanoylphorbol acetate 100 ng/mL) in THP-1 cells, and the addition of 30 ng/mL macrophage colony-stimulating factor further enhanced LRP expression.	Tetradecanoylphorbol Acetate	139-167	LDL receptor related protein 1	Homo sapiens	19-22
8020150-4	1994	The communication was partially restored after 4 h of TPA exposure and almost fully restored by 24 h, whereas in endosulfan-exposed cells the communication was completely down-regulated for the whole exposure-period of 24 h. Immunoblots of IAR 20 cell extracts indicated that TPA initially caused an increased phosphorylation of cx43.	Tetradecanoylphorbol Acetate	276-279	gap junction protein, alpha 1	Rattus norvegicus	329-333
8020150-11	1994	TPA causes a marked hyperphosphorylation of cx43, whereas endosulfan increases phosphorylation initially only slightly but longer exposure-periods lead to hypophosphorylation.	Tetradecanoylphorbol Acetate	0-3	gap junction protein, alpha 1	Rattus norvegicus	44-48
7515343-7	1994	When CD4+ T cells from patients with PBC were precultured with the combination of Con A and PMA, they mediated potent inhibitory activity similar to that of normal CD4+ T cells.	Tetradecanoylphorbol Acetate	92-95	CD4 molecule	Homo sapiens	5-8
7515343-7	1994	When CD4+ T cells from patients with PBC were precultured with the combination of Con A and PMA, they mediated potent inhibitory activity similar to that of normal CD4+ T cells.	Tetradecanoylphorbol Acetate	92-95	CD4 molecule	Homo sapiens	164-167
7515343-8	1994	Thus, CD4+, Leu-8+ T cells from patients with PBC have a defect of proliferation and suppressor function that is reversed by coculture with PMA.	Tetradecanoylphorbol Acetate	140-143	CD4 molecule	Homo sapiens	6-9
7925881-4	1994	Of the stimuli used (phorbol myristate acetate, retinoic acid, calcitriol), only calcitriol can induce differentiation of THP-1 cells, as assessed by CD14 expression.	Tetradecanoylphorbol Acetate	21-46	GLI family zinc finger 2	Homo sapiens	122-127
8194473-6	1994	The effect of AII on AT1-R mRNA levels was fully reproduced by the combination of calcium ionophore (A23187) and phorbol ester (12-O-tetradecanoylphorbol 13-acetate), suggesting that AII action was through protein kinase-C and possibly other Ca(2+)-sensitive protein kinases.	Tetradecanoylphorbol Acetate	128-164	NLR family pyrin domain containing 3	Homo sapiens	14-17
8194473-6	1994	The effect of AII on AT1-R mRNA levels was fully reproduced by the combination of calcium ionophore (A23187) and phorbol ester (12-O-tetradecanoylphorbol 13-acetate), suggesting that AII action was through protein kinase-C and possibly other Ca(2+)-sensitive protein kinases.	Tetradecanoylphorbol Acetate	128-164	NLR family pyrin domain containing 3	Homo sapiens	183-186
7909823-6	1994	Primed cells are enriched in CD45R0hi and CD31- cells, and upon stimulation with PMA+ ionomycin they release significant amounts of IL-2, IFN-gamma, IL-4, IL-5, and IL-10.	Tetradecanoylphorbol Acetate	81-84	interleukin 2	Homo sapiens	132-136
8195701-5	1994	Under these conditions interleukin-8 (IL-8) production was attenuated (by 50-90%) in response to lipopolysaccharide, granulocyte-macrophage colony-stimulating factor, and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	171-196	C-X-C motif chemokine ligand 8	Homo sapiens	23-36
8195701-5	1994	Under these conditions interleukin-8 (IL-8) production was attenuated (by 50-90%) in response to lipopolysaccharide, granulocyte-macrophage colony-stimulating factor, and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	171-196	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
8197564-8	1994	Incubation experiments revealed a simultaneous in vitro release of VIP and PP with a significant increase by either carbachol or phorbol myristate acetate but not by theophylline or caerulein.	Tetradecanoylphorbol Acetate	129-154	vasoactive intestinal peptide	Homo sapiens	67-70
8197564-10	1994	Octreotide (somatostatin analogue [SMS 201-995]) significantly inhibited the carbachol and phorbol myristate acetate-stimulated VIP and PP release.	Tetradecanoylphorbol Acetate	91-116	vasoactive intestinal peptide	Homo sapiens	128-131
7909823-6	1994	Primed cells are enriched in CD45R0hi and CD31- cells, and upon stimulation with PMA+ ionomycin they release significant amounts of IL-2, IFN-gamma, IL-4, IL-5, and IL-10.	Tetradecanoylphorbol Acetate	81-84	interferon gamma	Homo sapiens	138-147
8168085-4	1994	The involvement of PKC in the radioprotective effect conferred by bFGF was suggested by the demonstration that nonspecific PKC activation by short-term exposure (30 min) to the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA; 30 ng/ml) mimicked the radioprotective effect of bFGF.	Tetradecanoylphorbol Acetate	192-228	fibroblast growth factor 2	Bos taurus	66-70
8168085-4	1994	The involvement of PKC in the radioprotective effect conferred by bFGF was suggested by the demonstration that nonspecific PKC activation by short-term exposure (30 min) to the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA; 30 ng/ml) mimicked the radioprotective effect of bFGF.	Tetradecanoylphorbol Acetate	192-228	fibroblast growth factor 2	Bos taurus	284-288
7909823-6	1994	Primed cells are enriched in CD45R0hi and CD31- cells, and upon stimulation with PMA+ ionomycin they release significant amounts of IL-2, IFN-gamma, IL-4, IL-5, and IL-10.	Tetradecanoylphorbol Acetate	81-84	interleukin 4	Homo sapiens	149-153
8168085-4	1994	The involvement of PKC in the radioprotective effect conferred by bFGF was suggested by the demonstration that nonspecific PKC activation by short-term exposure (30 min) to the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA; 30 ng/ml) mimicked the radioprotective effect of bFGF.	Tetradecanoylphorbol Acetate	230-233	fibroblast growth factor 2	Bos taurus	66-70
8194586-1	1994	Vasoactive intestinal peptide (VIP) primed the respiratory burst of human neutrophils in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	101-126	vasoactive intestinal peptide	Homo sapiens	31-34
8168085-5	1994	Furthermore, treatment of the cells with the PKC inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (20 microM) abrogated the radioprotective effect of bFGF, as was observed after the depletion of cellular PKC by overnight preincubation with high-dose TPA (200 nM).	Tetradecanoylphorbol Acetate	257-260	fibroblast growth factor 2	Bos taurus	157-161
8168086-10	1994	TPA and retinoic acid generally down-regulated MSH receptors but had no effect on HBL cells.	Tetradecanoylphorbol Acetate	0-3	proopiomelanocortin	Homo sapiens	47-50
7924884-4	1994	Thrombin stimulated dose-dependently the production of tPA, uPA and PAI-1 from the cells grown in either 5 or 33 mM glucose.	Tetradecanoylphorbol Acetate	55-58	coagulation factor II, thrombin	Homo sapiens	0-8
7908719-9	1994	RESULTS: In response to phytohemagglutinin, the production of interferon gamma by mononuclear cells from the patients was lower than in normal subjects (P &lt; 0.001), whereas stimulation with ionomycin and phorbol myristate acetate led to normal production of interferon gamma in the patients.	Tetradecanoylphorbol Acetate	207-232	interferon gamma	Homo sapiens	62-78
7917514-2	1994	Secretion of IL-2 and TNF-alpha, surface expression of IL-2R, and DNA-binding activity of NF-kappa B and AP-1 (Fos/Jun) complex in response to phorbol myristate acetate, TNF-alpha, or immobilized antibodies to CD3 were monitored.	Tetradecanoylphorbol Acetate	143-168	interleukin 2	Homo sapiens	13-17
7917514-2	1994	Secretion of IL-2 and TNF-alpha, surface expression of IL-2R, and DNA-binding activity of NF-kappa B and AP-1 (Fos/Jun) complex in response to phorbol myristate acetate, TNF-alpha, or immobilized antibodies to CD3 were monitored.	Tetradecanoylphorbol Acetate	143-168	nuclear factor kappa B subunit 1	Homo sapiens	90-100
8074477-0	1994	PMA induces shift from chondroitin to heparan sulphate on proteoglycans correlating with fibronectin adhesion of MDS human leukemia cells.	Tetradecanoylphorbol Acetate	0-3	fibronectin 1	Homo sapiens	89-100
7924884-1	1994	To elucidate a role of tPA, uPA and PAI-1 for the development of diabetic glomerulosclerosis, the effect of high glucose concentration on the production of both basal and thrombin-mediated tPA, uPA and PAI-1 antigens from human mesangial cells was investigated.	Tetradecanoylphorbol Acetate	23-26	coagulation factor II, thrombin	Homo sapiens	171-179
7924884-1	1994	To elucidate a role of tPA, uPA and PAI-1 for the development of diabetic glomerulosclerosis, the effect of high glucose concentration on the production of both basal and thrombin-mediated tPA, uPA and PAI-1 antigens from human mesangial cells was investigated.	Tetradecanoylphorbol Acetate	189-192	coagulation factor II, thrombin	Homo sapiens	171-179
8174632-3	1994	The tumor promoter phorbol 12-myristate 13-acetate (PMA) inhibited this response in quiescent cells stimulated with serum or thrombin.	Tetradecanoylphorbol Acetate	19-50	coagulation factor II, thrombin	Homo sapiens	125-133
7512497-7	1994	The protein kinase-C activator 12-O-tetradecanoyl phorbol-13-acetate and cytokines, tumor necrosis factor-alpha and interferon-gamma, inhibited H19 and IGF-II RNA accumulation.	Tetradecanoylphorbol Acetate	31-68	tumor necrosis factor	Homo sapiens	84-111
8174632-3	1994	The tumor promoter phorbol 12-myristate 13-acetate (PMA) inhibited this response in quiescent cells stimulated with serum or thrombin.	Tetradecanoylphorbol Acetate	52-55	coagulation factor II, thrombin	Homo sapiens	125-133
8175167-6	1994	This effect was specific to TGF-beta 1 autoinduction since similar elevations in TGF-beta 1 mRNA levels were observed when vascular smooth muscle cells from the two rat strains were exposed to phorbol myristate acetate, basic fibroblast growth factor, or platelet-derived growth factor-BB.	Tetradecanoylphorbol Acetate	193-218	transforming growth factor, beta 1	Rattus norvegicus	28-38
8175167-6	1994	This effect was specific to TGF-beta 1 autoinduction since similar elevations in TGF-beta 1 mRNA levels were observed when vascular smooth muscle cells from the two rat strains were exposed to phorbol myristate acetate, basic fibroblast growth factor, or platelet-derived growth factor-BB.	Tetradecanoylphorbol Acetate	193-218	transforming growth factor, beta 1	Rattus norvegicus	81-91
8071611-12	1994	IFN-gamma at concentrations that maximally inhibit LDL oxidation stimulated the phorbol myristate acetate (PMA)-induced production of O2- 1.4-times greater than control cells after one hour.	Tetradecanoylphorbol Acetate	80-105	interferon gamma	Mus musculus	0-9
8071611-12	1994	IFN-gamma at concentrations that maximally inhibit LDL oxidation stimulated the phorbol myristate acetate (PMA)-induced production of O2- 1.4-times greater than control cells after one hour.	Tetradecanoylphorbol Acetate	107-110	interferon gamma	Mus musculus	0-9
8158122-6	1994	However, reagents such as nerve growth factor (NGF) and the phorbol ester phorbol 12-myristate 13-acetate (PMA), which induce phenotypical differentiation of the SH-SY5Y neuroblastoma cell line, activated NF-kappa B, but only in that particular cell line.	Tetradecanoylphorbol Acetate	74-105	nuclear factor kappa B subunit 1	Homo sapiens	205-215
8158122-6	1994	However, reagents such as nerve growth factor (NGF) and the phorbol ester phorbol 12-myristate 13-acetate (PMA), which induce phenotypical differentiation of the SH-SY5Y neuroblastoma cell line, activated NF-kappa B, but only in that particular cell line.	Tetradecanoylphorbol Acetate	107-110	nuclear factor kappa B subunit 1	Homo sapiens	205-215
8182337-2	1994	To better understand the refractoriness of monocytes to alterations in levels of CD4 mRNA, we treated HIV-IIIB chronically infected U-937 cells with phorbol myristate acetate (PMA), a known stimulus of HIV gene expression.	Tetradecanoylphorbol Acetate	176-179	CD4 molecule	Homo sapiens	81-84
7489328-11	1994	Consequently, we examined the effect of alpha-MSH on CRF release induced by phorbol myristate acetate (PMA), which in the presence of Ca2+ stimulates PKC.	Tetradecanoylphorbol Acetate	76-101	proopiomelanocortin	Homo sapiens	40-49
8071057-5	1994	Jurkat cells were used as a test model for TH1-type T-cells and were stimulated for IL-2 release with a combination of phytohemagglutinin and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	142-167	interleukin 2	Homo sapiens	84-88
8182158-7	1994	The production of alpha MSH and ACTH could be significantly upregulated both at the protein and mRNA level upon treatment with phorbol myristate acetate, ultraviolet light, or interleukin 1.	Tetradecanoylphorbol Acetate	127-152	proopiomelanocortin	Homo sapiens	18-27
8182158-7	1994	The production of alpha MSH and ACTH could be significantly upregulated both at the protein and mRNA level upon treatment with phorbol myristate acetate, ultraviolet light, or interleukin 1.	Tetradecanoylphorbol Acetate	127-152	proopiomelanocortin	Homo sapiens	32-36
8052253-5	1994	Using various concentrations of heavy metal salts we have developed the optimized procedure for induction of recombinant tPA synthesis which is controlled by the mouse MT1 promoter.	Tetradecanoylphorbol Acetate	121-124	metallothionein 1	Mus musculus	168-171
8058064-7	1994	In contrast, 12-O-tetradecanoylphorbol 13-acetate stimulated ERK activity to the same degree in all three cell types regardless of their IGF-I receptor status.	Tetradecanoylphorbol Acetate	13-49	mitogen-activated protein kinase 1	Homo sapiens	61-64
8190095-2	1994	The synthesis of the sulfidopeptide LTs, LTC4 and LTD4, was specifically inhibited in cells incubated in the presence of both A23187 and phorbol-12-myristate-13-acetate (PMA), an activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	137-168	proline rich transmembrane protein 2	Homo sapiens	192-208
8190095-2	1994	The synthesis of the sulfidopeptide LTs, LTC4 and LTD4, was specifically inhibited in cells incubated in the presence of both A23187 and phorbol-12-myristate-13-acetate (PMA), an activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	137-168	proline rich transmembrane protein 2	Homo sapiens	210-213
7489328-11	1994	Consequently, we examined the effect of alpha-MSH on CRF release induced by phorbol myristate acetate (PMA), which in the presence of Ca2+ stimulates PKC.	Tetradecanoylphorbol Acetate	103-106	proopiomelanocortin	Homo sapiens	40-49
7936052-4	1994	Redistribution of cytosolic PKC to the membranous fraction was elicited in control brain slices by 162 nM PMA in the presence of K+ (65 mM).	Tetradecanoylphorbol Acetate	106-109	proline rich transmembrane protein 2	Homo sapiens	28-31
8170999-0	1994	A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum.	Tetradecanoylphorbol Acetate	108-139	mitogen-activated protein kinase 1	Homo sapiens	18-55
8182306-6	1994	12-O-tetradecanoyl phorbol 13-acetate (TPA) (0.1-100ng/ml), a protein-kinase C activator, also stimulated aromatase activity and increased the P-450arom concentration.	Tetradecanoylphorbol Acetate	0-37	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	143-152
8182306-6	1994	12-O-tetradecanoyl phorbol 13-acetate (TPA) (0.1-100ng/ml), a protein-kinase C activator, also stimulated aromatase activity and increased the P-450arom concentration.	Tetradecanoylphorbol Acetate	39-42	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	143-152
8170999-0	1994	A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum.	Tetradecanoylphorbol Acetate	108-139	mitogen-activated protein kinase 1	Homo sapiens	57-60
8170972-5	1994	bcl-2-/- lymphocytes, however, could respond normally to various stimuli including anti-CD3, Con A, phorbol 12-myristate 13-acetate plus ionomycin, interleukin 2, lipopolysaccharide, and anti-IgM antibody.	Tetradecanoylphorbol Acetate	100-131	B cell leukemia/lymphoma 2	Mus musculus	0-5
8171009-4	1994	Within this sequence there is a 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive element (TRE) which is essential for T1 promoter induction in response to the forced expression of the transcription factor AP-1 in NIH 3T3 fibroblasts and F9 teratocarcinoma cells.	Tetradecanoylphorbol Acetate	32-68	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	210-214
8175693-1	1994	Treatment of adipocytes with insulin or phorbol 12-myristate 13-acetate (PMA) results in transient activation of mitogen-activated protein kinase kinase (MEK) (Tmax = 90 s) and mitogen-activated protein kinase (MAPK) (Tmax = 300 s).	Tetradecanoylphorbol Acetate	40-71	insulin	Homo sapiens	29-36
8175693-1	1994	Treatment of adipocytes with insulin or phorbol 12-myristate 13-acetate (PMA) results in transient activation of mitogen-activated protein kinase kinase (MEK) (Tmax = 90 s) and mitogen-activated protein kinase (MAPK) (Tmax = 300 s).	Tetradecanoylphorbol Acetate	40-71	mitogen-activated protein kinase kinase 7	Homo sapiens	154-157
8171009-4	1994	Within this sequence there is a 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive element (TRE) which is essential for T1 promoter induction in response to the forced expression of the transcription factor AP-1 in NIH 3T3 fibroblasts and F9 teratocarcinoma cells.	Tetradecanoylphorbol Acetate	70-73	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	210-214
8175693-1	1994	Treatment of adipocytes with insulin or phorbol 12-myristate 13-acetate (PMA) results in transient activation of mitogen-activated protein kinase kinase (MEK) (Tmax = 90 s) and mitogen-activated protein kinase (MAPK) (Tmax = 300 s).	Tetradecanoylphorbol Acetate	73-76	insulin	Homo sapiens	29-36
8175693-1	1994	Treatment of adipocytes with insulin or phorbol 12-myristate 13-acetate (PMA) results in transient activation of mitogen-activated protein kinase kinase (MEK) (Tmax = 90 s) and mitogen-activated protein kinase (MAPK) (Tmax = 300 s).	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase kinase 7	Homo sapiens	154-157
7519561-3	1994	The maximal decrease (50 +/- 13% of control) occurred at 6 h, followed by a gradual return to the control level within 24 h. H-7 (30 microM), a relatively specific protein kinase C inhibitor, inhibited decrease in the expression of angiotensin II receptor mRNA induced by 6 h angiotensin II treatment, while 6 h stimulation by 0.3 microM phorbol 12-myristate 13-acetate also induced a decrease (35 +/- 8% of control) in the expression of angiotensin II receptor mRNA.	Tetradecanoylphorbol Acetate	338-369	angiotensinogen	Rattus norvegicus	232-246
8175699-3	1994	The amount of HGF receptor mRNA increases from 3- to 5-fold after stimulation of confluent monolayers by serum and up to 10-fold after stimulation of protein kinase C by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	170-206	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	14-26
8175699-3	1994	The amount of HGF receptor mRNA increases from 3- to 5-fold after stimulation of confluent monolayers by serum and up to 10-fold after stimulation of protein kinase C by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	208-211	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	14-26
8175699-6	1994	Transcription of a reporter gene under control of the cloned 297 base pair c-MET promoter was also stimulated by serum, TPA, or HGF.	Tetradecanoylphorbol Acetate	120-123	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	75-80
7512570-7	1994	A protein kinase C-activating phorbol ester, phorbol 12-myristate 13-acetate, and a membrane-permeable diacylglycerol, 1,2-dioctanoyl-glycerol, similarly inhibited the IL-1 beta-induced nitrite production and iNOS mRNA and protein expression, although repetitive additions were needed in the case of diacylglycerol.	Tetradecanoylphorbol Acetate	45-76	interleukin 1 beta	Homo sapiens	168-177
7909661-4	1994	Dexamethasone inhibited the DMSO-induced increase of CD11b cell surface expression as well as the oxidative response and PLD activation triggered by 4 beta-phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	151-187	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	121-124
7908894-2	1994	K562/TPA was found to be a non-P-glycoprotein-mediated multidrug-resistant cell line, in which intracellular drug accumulation was not reduced.	Tetradecanoylphorbol Acetate	5-8	ATP binding cassette subfamily B member 1	Homo sapiens	31-45
8144636-7	1994	Treatment of cells with chelerythrine, an inhibitor of PKC, and phorbol ester down-regulation of PKC inhibited [3H]PEt production by both PMA and nucleotides.	Tetradecanoylphorbol Acetate	138-141	protein kinase C alpha	Canis lupus familiaris	55-58
7512730-6	1994	Either acidic fibroblast growth factor or phorbol 12-myristate 13-acetate can replace serum as a cofactor in IL-6-induced ZR-75-1-Tx cell detachment.	Tetradecanoylphorbol Acetate	42-73	interleukin 6	Homo sapiens	109-113
8144979-3	1994	In this study, we show that the cellular levels of the NF-kappa B DNA binding proteins (but not AP1 or SP1) are markedly reduced in these cell mutants both at the mRNA and protein levels, resulting in reduced nuclear localization of p50/p65 after PMA induction or treatment with the lymphokine TNF-alpha.	Tetradecanoylphorbol Acetate	247-250	nuclear factor kappa B subunit 1	Homo sapiens	233-236
8144636-7	1994	Treatment of cells with chelerythrine, an inhibitor of PKC, and phorbol ester down-regulation of PKC inhibited [3H]PEt production by both PMA and nucleotides.	Tetradecanoylphorbol Acetate	138-141	protein kinase C alpha	Canis lupus familiaris	97-100
8043296-0	1994	Differential effects of phorbol 12-myristate 13-acetate and diacylglycerols on thromboxane A2-independent phospholipase A2 activation in collage-stimulated human platelets.	Tetradecanoylphorbol Acetate	24-55	phospholipase A2 group IB	Homo sapiens	106-122
8043296-4	1994	Interestingly, 1,3-DiC8, which is a poor activator of PKC, was as effective as the other two DAGs (OAG and 1,2-DiC8) in priming TxA2-independent PLA2 activation, but was less effective than PMA in platelets stimulated with A23187.	Tetradecanoylphorbol Acetate	190-193	phospholipase A2 group IB	Homo sapiens	145-149
8142654-5	1994	The wt1 transcripts were also downregulated in HL60 cells during differentiation to monocytes by vitamin D3 or 12-o-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	111-148	WT1 transcription factor	Homo sapiens	4-7
7522976-0	1994	Induction of membrane ruffling by growth factors in morphologically TPA-resistant Balb/c3T3 TR4 cells.	Tetradecanoylphorbol Acetate	68-71	nuclear receptor subfamily 2, group C, member 2	Mus musculus	92-95
8149484-1	1994	The involvement of protein kinase C (PKC), a 12-O-tetradecanoylphorbol-13-acetate (TPA) receptor, in the transcriptional regulation of TPA-inducible genes was determined.	Tetradecanoylphorbol Acetate	83-86	protein kinase C alpha	Homo sapiens	37-40
8149484-4	1994	To determine the effects of overexpression of PKC alpha K and PKC delta K on the AP-1-mediated TPA-inducible genes, we transfected into COS cells the PKC alpha K or PKC delta K expression plasmids with collagenase chloramphenicol acetyltransferase (CAT) reporter construct containing one TPA responsive element (TRE), or a construct containing five synthetic TRE linked to a thymidine kinase promoter.	Tetradecanoylphorbol Acetate	95-98	protein kinase C alpha	Homo sapiens	46-55
8149484-10	1994	Cotransfection of PKC alpha K or PKC delta K expression plasmids with a TPA-inducible ODC luc construct (-72/+130-ODC-luc) into HeLa cells resulted in an increased luc activity.	Tetradecanoylphorbol Acetate	72-75	protein kinase C alpha	Homo sapiens	18-27
8149483-1	1994	During studies to determine the mechanism of tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA), we found that TPA downregulates mouse epidermal retinoic acid nuclear receptors (RAR), a superfamily of nuclear steroid/thyroid receptors implicated in mediating effects of retinoic acid (RA).	Tetradecanoylphorbol Acetate	64-100	promotion susceptibility QTL 1	Mus musculus	102-105
8149483-1	1994	During studies to determine the mechanism of tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA), we found that TPA downregulates mouse epidermal retinoic acid nuclear receptors (RAR), a superfamily of nuclear steroid/thyroid receptors implicated in mediating effects of retinoic acid (RA).	Tetradecanoylphorbol Acetate	64-100	promotion susceptibility QTL 1	Mus musculus	122-125
7522976-1	1994	To investigate the biological characteristics of a Balb/c3T3 variant TR4 clone which is morphologically resistant to TPA and hypersensitive to v-src induced metastasis, we compared the responsiveness of the variant and its parent cells to growth factor-induced membrane ruffling.	Tetradecanoylphorbol Acetate	117-120	nuclear receptor subfamily 2, group C, member 2	Mus musculus	69-72
8149484-11	1994	These results indicate that both PKC alpha (calcium dependent) and PKC delta (calcium independent) may mediate the transcription of TPA-inducible genes through both AP-1 and non-AP-1 sequences.	Tetradecanoylphorbol Acetate	132-135	protein kinase C alpha	Homo sapiens	33-42
7522976-6	1994	When TR4 cells were incubated with TPA just before stimulation with these growth factors, growth factor-induced membrane ruffling was completely inhibited.	Tetradecanoylphorbol Acetate	35-38	nuclear receptor subfamily 2, group C, member 2	Mus musculus	5-8
7522976-7	1994	Also, 5 out of 6 clones of stable fusion cells between TR4 and parent cells showed the parental type of responses to TPA and growth factors, indicating that the TR4 phenotype is recessive.	Tetradecanoylphorbol Acetate	117-120	nuclear receptor subfamily 2, group C, member 2	Mus musculus	55-58
7522976-7	1994	Also, 5 out of 6 clones of stable fusion cells between TR4 and parent cells showed the parental type of responses to TPA and growth factors, indicating that the TR4 phenotype is recessive.	Tetradecanoylphorbol Acetate	117-120	nuclear receptor subfamily 2, group C, member 2	Mus musculus	161-164
8145051-10	1994	Activation with phorbol myristate acetate in combination with Ca-ionophore induced IL-4 secretion in both populations, but preferentially in the CDw60+ subset, whereas the vast majority of interferon gamma was produced by the CDw60-CD8+ cells.	Tetradecanoylphorbol Acetate	16-41	interleukin 4	Homo sapiens	83-87
7512058-7	1994	Morphological examination of control, PMA-treated HUVECs, as well as PMA-treated HUVECs receiving TIMP or BB-94, revealed that MMP inhibition resulted in a block to invasion and tubule formation within the collagen gels.	Tetradecanoylphorbol Acetate	69-72	TIMP metallopeptidase inhibitor 1	Homo sapiens	98-102
8149968-5	1994	Interestingly, addition of either recombinant interleukin (IL)-2 or phorbol 12-myristate 13-acetate to the cell culture was able to completely restore impaired anti-CD3-induced proliferation in diabetic T cells, suggesting the presence of a defect through the TcR/CD3 pathway, located upstream of protein kinase C (PKC) activation and resulting in low IL-2 production and proliferation.	Tetradecanoylphorbol Acetate	68-99	interleukin 2	Homo sapiens	352-356
8011989-3	1994	Increases in the intracellular Ca2+ concentration of human platelets caused by thrombin, at any concentration, were markedly inhibited by the prior addition of 25 nM TPA in a time-dependent manner.	Tetradecanoylphorbol Acetate	166-169	coagulation factor II, thrombin	Homo sapiens	79-87
8011989-4	1994	However, the effects of TPA on platelet aggregation and secretion induced by thrombin varied, depending upon the agonist concentration; the PKC activator markedly enhanced the aggregation and secretion induced by lower concentrations of thrombin but had a tendency to weakly inhibit those induced by higher concentrations of thrombin.	Tetradecanoylphorbol Acetate	24-27	coagulation factor II, thrombin	Homo sapiens	77-85
8011989-4	1994	However, the effects of TPA on platelet aggregation and secretion induced by thrombin varied, depending upon the agonist concentration; the PKC activator markedly enhanced the aggregation and secretion induced by lower concentrations of thrombin but had a tendency to weakly inhibit those induced by higher concentrations of thrombin.	Tetradecanoylphorbol Acetate	24-27	coagulation factor II, thrombin	Homo sapiens	237-245
8011989-4	1994	However, the effects of TPA on platelet aggregation and secretion induced by thrombin varied, depending upon the agonist concentration; the PKC activator markedly enhanced the aggregation and secretion induced by lower concentrations of thrombin but had a tendency to weakly inhibit those induced by higher concentrations of thrombin.	Tetradecanoylphorbol Acetate	24-27	coagulation factor II, thrombin	Homo sapiens	237-245
8011989-6	1994	There was a good time-dependent correlation of the TPA effects among the three parameters, namely, the phosphorylation of the 47-kDa protein, inhibition of the [Ca2+]i increase induced by thrombin, and enhanced ionomycin effects in aggregation and release.	Tetradecanoylphorbol Acetate	51-54	coagulation factor II, thrombin	Homo sapiens	188-196
8018594-4	1994	In contrast, in cells stimulated with phorbol myristate acetate (PMA)/A23187, PGE2 enhanced the production of IL-4 and IL-5, and only partially inhibited the production of other cytokines.	Tetradecanoylphorbol Acetate	38-63	interleukin 4	Homo sapiens	110-114
8018594-4	1994	In contrast, in cells stimulated with phorbol myristate acetate (PMA)/A23187, PGE2 enhanced the production of IL-4 and IL-5, and only partially inhibited the production of other cytokines.	Tetradecanoylphorbol Acetate	65-68	interleukin 4	Homo sapiens	110-114
8168335-9	1994	Both phorbol myristate acetate and N-formyl-methionyl-leucylphenylalanine induced further release of nitric oxide, which was increased by preincubation with lipopolysaccharide, interleukin-6 and interferon-gamma.	Tetradecanoylphorbol Acetate	5-30	interleukin 6	Homo sapiens	177-190
8162171-2	1994	During short-term incubations (less than 24 h), a low calcium concentration (0.5 mmol/l) and protein kinase C activator TPA (12-O-tetradecanoyl phorbol 13-acetate) (160 nmol/l) increased PTH secretion (60%; p &lt; 0.05), while a high extracellular calcium concentration (2.5 mmol/l) reduced PTH secretion (60%; p &lt; 0.05).	Tetradecanoylphorbol Acetate	125-162	parathyroid hormone	Homo sapiens	187-190
8162171-2	1994	During short-term incubations (less than 24 h), a low calcium concentration (0.5 mmol/l) and protein kinase C activator TPA (12-O-tetradecanoyl phorbol 13-acetate) (160 nmol/l) increased PTH secretion (60%; p &lt; 0.05), while a high extracellular calcium concentration (2.5 mmol/l) reduced PTH secretion (60%; p &lt; 0.05).	Tetradecanoylphorbol Acetate	125-162	parathyroid hormone	Homo sapiens	291-294
8162171-3	1994	The TPA could block the inhibitory effect of a high calcium level on PTH peptide secretion.	Tetradecanoylphorbol Acetate	4-7	parathyroid hormone	Homo sapiens	69-72
8162171-6	1994	The TPA reduced PTH mRNA accumulation down to 30% (p &lt; 0.05) and PTH secretion down to 14% (p &lt; 0.05) in a time- and dose-dependent fashion.	Tetradecanoylphorbol Acetate	4-7	parathyroid hormone	Homo sapiens	16-19
8162171-7	1994	The TPA also reversed the stimulatory effect of hypocalcemia on PTH mRNA accumulation and peptide secretion.	Tetradecanoylphorbol Acetate	4-7	parathyroid hormone	Homo sapiens	64-67
7912545-5	1994	Furthermore, cell-surface CD4 down-modulation by phorbol myristate acetate or anti-CD4 mAbs was similar in the two subsets, which express the same amounts of both cell-surface CD4 and CD4-associated p56lck.	Tetradecanoylphorbol Acetate	49-74	CD4 molecule	Homo sapiens	26-29
8071985-9	1994	While TPA treatment induced phosphorylation of connexin43 in these cells, it reduced the expression of connexin45.	Tetradecanoylphorbol Acetate	6-9	gap junction protein gamma 1	Homo sapiens	103-113
8071985-10	1994	Furthermore, the connexin45 expressed after TPA treatment was not phosphorylated.	Tetradecanoylphorbol Acetate	44-47	gap junction protein gamma 1	Homo sapiens	17-27
8028182-8	1994	In this context, MEG-01, a megakaryoblastic cell line which produces active TGF-beta was underwent differentiation to produce platelet-like bleb with TPA treatment.	Tetradecanoylphorbol Acetate	150-153	transforming growth factor beta 1	Homo sapiens	76-84
8169821-5	1994	Prior exposure of cells for 5 min with the protein kinase C activators phorbol 12-myristate 13-acetate (8-80 nM) and phorbol 12,13-dibutyrate (80 nM) weakly inhibited (&lt; or = 30%) the peak Cai++ increase in response to thrombin but completely blocked the Cai++ response to PTH.	Tetradecanoylphorbol Acetate	71-102	coagulation factor II	Rattus norvegicus	222-230
8169825-6	1994	In addition, morphine treatment amplified (P &lt; .01) the priming effect of lipopolysaccharide on phorbol myristate acetate-triggered superoxide anion production by microglial cell cultures, and this effect was abrogated (P &lt; .01) by anti-TNF-alpha antibody.	Tetradecanoylphorbol Acetate	99-124	tumor necrosis factor	Homo sapiens	243-252
8139548-0	1994	rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.	Tetradecanoylphorbol Acetate	152-155	insulin	Homo sapiens	23-30
8139561-10	1994	Stimulation with tetradecanoyl phorbol acetate (TPA) resulted in the nuclear translocation of both NF-kappa B and c-Rel-p65 (RelA) in HeLa cells and of NF-kappa B in HepG2 cells but had no effect on either complex in K562 cells.	Tetradecanoylphorbol Acetate	17-46	nuclear factor kappa B subunit 1	Homo sapiens	99-109
8139561-10	1994	Stimulation with tetradecanoyl phorbol acetate (TPA) resulted in the nuclear translocation of both NF-kappa B and c-Rel-p65 (RelA) in HeLa cells and of NF-kappa B in HepG2 cells but had no effect on either complex in K562 cells.	Tetradecanoylphorbol Acetate	17-46	nuclear factor kappa B subunit 1	Homo sapiens	152-162
8139561-10	1994	Stimulation with tetradecanoyl phorbol acetate (TPA) resulted in the nuclear translocation of both NF-kappa B and c-Rel-p65 (RelA) in HeLa cells and of NF-kappa B in HepG2 cells but had no effect on either complex in K562 cells.	Tetradecanoylphorbol Acetate	48-51	nuclear factor kappa B subunit 1	Homo sapiens	99-109
8139561-10	1994	Stimulation with tetradecanoyl phorbol acetate (TPA) resulted in the nuclear translocation of both NF-kappa B and c-Rel-p65 (RelA) in HeLa cells and of NF-kappa B in HepG2 cells but had no effect on either complex in K562 cells.	Tetradecanoylphorbol Acetate	48-51	nuclear factor kappa B subunit 1	Homo sapiens	152-162
8146596-3	1994	In combination with submitogenic concentrations of phorbol esters (PMA); LD6 MoAb was able to induce accumulation of mRNA specific for GM-CSF, gamma-IFN and TNF-alpha and release of these cytokines by LD6+ T-cell lines.	Tetradecanoylphorbol Acetate	67-70	tumor necrosis factor	Homo sapiens	157-166
8152914-1	1994	In human monocytic cell lines, tumor necrosis factor alpha (TNF alpha) expression is induced by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	96-121	tumor necrosis factor	Homo sapiens	31-58
7510705-6	1994	We found that bFGF and a protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate, significantly induced luciferase activity driven by the LDL receptor promoter, whereas 25-hydroxycholesterol reduced the luciferase activity in bFGF-stimulated cells.	Tetradecanoylphorbol Acetate	59-90	fibroblast growth factor 2	Homo sapiens	14-18
7510705-6	1994	We found that bFGF and a protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate, significantly induced luciferase activity driven by the LDL receptor promoter, whereas 25-hydroxycholesterol reduced the luciferase activity in bFGF-stimulated cells.	Tetradecanoylphorbol Acetate	59-90	fibroblast growth factor 2	Homo sapiens	236-240
8142369-4	1994	Addition of the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol 13-acetate (TPA), or the Ca2+ ionophore, ionomycin, mimicked the profile of GnRH-induced alpha and LH beta mRNA elevation.	Tetradecanoylphorbol Acetate	50-86	luteinizing hormone subunit beta	Rattus norvegicus	175-182
8147862-3	1994	The peptide stimulated Pi uptake dose-dependently at the range of 10(-11)-10(-7) M. Activation of protein kinase C (PKC) by 12-O-Tetradecanoyl phorbol-13-acetate (TPA) also increased Pi uptake in time- and dose-dependent manners similar to PTHrP.	Tetradecanoylphorbol Acetate	124-161	proline rich transmembrane protein 2	Homo sapiens	98-114
8147862-3	1994	The peptide stimulated Pi uptake dose-dependently at the range of 10(-11)-10(-7) M. Activation of protein kinase C (PKC) by 12-O-Tetradecanoyl phorbol-13-acetate (TPA) also increased Pi uptake in time- and dose-dependent manners similar to PTHrP.	Tetradecanoylphorbol Acetate	124-161	proline rich transmembrane protein 2	Homo sapiens	116-119
8147862-3	1994	The peptide stimulated Pi uptake dose-dependently at the range of 10(-11)-10(-7) M. Activation of protein kinase C (PKC) by 12-O-Tetradecanoyl phorbol-13-acetate (TPA) also increased Pi uptake in time- and dose-dependent manners similar to PTHrP.	Tetradecanoylphorbol Acetate	163-166	proline rich transmembrane protein 2	Homo sapiens	98-114
8147862-3	1994	The peptide stimulated Pi uptake dose-dependently at the range of 10(-11)-10(-7) M. Activation of protein kinase C (PKC) by 12-O-Tetradecanoyl phorbol-13-acetate (TPA) also increased Pi uptake in time- and dose-dependent manners similar to PTHrP.	Tetradecanoylphorbol Acetate	163-166	proline rich transmembrane protein 2	Homo sapiens	116-119
8147862-6	1994	The PTHrP-induced increase in Pi uptake was strongly inhibited by pretreating cells with PKC inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride (H-7) (50 microM), and by down-regulating PKC with a prolonged TPA pretreatment.	Tetradecanoylphorbol Acetate	231-234	proline rich transmembrane protein 2	Homo sapiens	89-92
8152914-1	1994	In human monocytic cell lines, tumor necrosis factor alpha (TNF alpha) expression is induced by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	96-121	tumor necrosis factor	Homo sapiens	60-69
8078506-0	1994	Changes of G1 cyclins, cdk2, and cyclin A during the differentiation of HL60 cells induced by TPA.	Tetradecanoylphorbol Acetate	94-97	cyclin A2	Homo sapiens	33-41
8132535-4	1994	Transient expression analysis in human BeWo choriocarcinoma cells, in which CYP19 is expressed, shows that hATRE-1 represses the expression of the bacterial chloramphenicol acetyltransferase reporter gene driven by the promoter of CYP19, whereas hATRE-2 enhances the reporter gene expression in response to 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	307-343	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	76-81
8132535-4	1994	Transient expression analysis in human BeWo choriocarcinoma cells, in which CYP19 is expressed, shows that hATRE-1 represses the expression of the bacterial chloramphenicol acetyltransferase reporter gene driven by the promoter of CYP19, whereas hATRE-2 enhances the reporter gene expression in response to 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	307-343	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	231-236
7510689-10	1994	We found that activation of Jurkat T cells by a combination of phytohemagglutinin and phorbol 12-myristate 13-acetate led to a dramatic inhibition of thrombin receptor mRNA expression and to a concomitant loss of the thrombin response.	Tetradecanoylphorbol Acetate	86-117	coagulation factor II, thrombin	Homo sapiens	150-158
7510689-10	1994	We found that activation of Jurkat T cells by a combination of phytohemagglutinin and phorbol 12-myristate 13-acetate led to a dramatic inhibition of thrombin receptor mRNA expression and to a concomitant loss of the thrombin response.	Tetradecanoylphorbol Acetate	86-117	coagulation factor II, thrombin	Homo sapiens	217-225
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tetradecanoylphorbol Acetate	151-182	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tetradecanoylphorbol Acetate	151-182	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tetradecanoylphorbol Acetate	184-187	C-X-C motif chemokine ligand 8	Homo sapiens	79-92
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tetradecanoylphorbol Acetate	184-187	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
8141770-3	1994	Activation of superoxide production by phorbol 12-myristate 13-acetate or formylmethionyl-leucyl-phenylalanine in whole cells, and by SDS in the cell-free assay, led to the dissociation of some of the p21rac2 from rhoGDI and its movement to the plasma membrane together with p47phox and p67phox.	Tetradecanoylphorbol Acetate	39-70	Rac family small GTPase 2	Homo sapiens	201-208
8135784-1	1994	The P sequence of the human interleukin-4 (IL-4) gene, which was defined as a responsive element for phorbol 12-myristate 13-acetate and calcium ionophore (A23187) in Jurkat T cells, shares sequence similarity with the NF-kappa B and the NF-AT binding sites.	Tetradecanoylphorbol Acetate	101-132	interleukin 4	Homo sapiens	28-41
8135784-1	1994	The P sequence of the human interleukin-4 (IL-4) gene, which was defined as a responsive element for phorbol 12-myristate 13-acetate and calcium ionophore (A23187) in Jurkat T cells, shares sequence similarity with the NF-kappa B and the NF-AT binding sites.	Tetradecanoylphorbol Acetate	101-132	interleukin 4	Homo sapiens	43-47
8135784-1	1994	The P sequence of the human interleukin-4 (IL-4) gene, which was defined as a responsive element for phorbol 12-myristate 13-acetate and calcium ionophore (A23187) in Jurkat T cells, shares sequence similarity with the NF-kappa B and the NF-AT binding sites.	Tetradecanoylphorbol Acetate	101-132	nuclear factor kappa B subunit 1	Homo sapiens	219-229
8135786-1	1994	The effect of thalidomide [racemic (DL-) form and optically pure (D- and L-) forms] on tumor necrosis factor (TNF) alpha production by human leukemia cell lines (HL-60, K562 and U937) stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) was investigated.	Tetradecanoylphorbol Acetate	200-236	tumor necrosis factor	Homo sapiens	87-120
8135786-2	1994	Though thalidomide has been regarded as a specific inhibitor of TNF-alpha production, our study indicated that all forms of thalidomide enhanced (but did not inhibit) the TPA-induced TNF-alpha production by the human leukemia cell lines investigated.	Tetradecanoylphorbol Acetate	171-174	tumor necrosis factor	Homo sapiens	183-192
8135804-2	1994	Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after the treatment of recombinant interferon-gamma (rIFN-gamma) resulted in the increased accumulation of nitrite in the medium.	Tetradecanoylphorbol Acetate	58-89	interferon gamma	Mus musculus	131-147
8135804-2	1994	Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after the treatment of recombinant interferon-gamma (rIFN-gamma) resulted in the increased accumulation of nitrite in the medium.	Tetradecanoylphorbol Acetate	91-94	interferon gamma	Mus musculus	131-147
8079811-4	1994	Peritoneal administration of IL-1 beta caused elicitation of cells which were enriched in eosinophils; however, the functional responses of the cells in all three groups were broadly similar in terms of the ability of the agonists FMLP, PMA and A23187 to initiate superoxide generation, beta-glucuronidase secretion and leukotriene generation.	Tetradecanoylphorbol Acetate	237-240	interleukin 1 beta	Rattus norvegicus	29-38
8119777-8	1994	The expression of NCA-50/90 by U-937 and THP-1 was down-regulated at both the protein and mRNA levels during cell differentiation from monoblastoid to monocyte/macrophage-like cells induced by stimulation with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	210-241	CEA cell adhesion molecule 3	Homo sapiens	18-21
8119777-8	1994	The expression of NCA-50/90 by U-937 and THP-1 was down-regulated at both the protein and mRNA levels during cell differentiation from monoblastoid to monocyte/macrophage-like cells induced by stimulation with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	210-241	GLI family zinc finger 2	Homo sapiens	41-46
7509804-4	1994	With THP-1 cells, PMA also induced the production of 92-kDa gelatinase fully, but unlike U937 cells, the combination of PMA and 1,25-(OH)2D3 was required for substantial interstitial collagenase biosynthesis.	Tetradecanoylphorbol Acetate	18-21	GLI family zinc finger 2	Homo sapiens	5-10
8135860-4	1994	Man-SOD exhibited a superior inhibitory effect on superoxide anion release from inflammatory macrophages stimulated by phorbol-myristate acetate.	Tetradecanoylphorbol Acetate	119-144	superoxide dismutase 1	Homo sapiens	4-7
8125975-2	1994	Following anti-IgM antibody and phorbol 12-myristate 13-acetate (PMA) stimulation, we demonstrate the activation of Ras, Raf-1, and MAPK/ERK kinase (MEK), all of which are thought to participate in an important signaling cascade that leads to MAPK activation.	Tetradecanoylphorbol Acetate	32-63	mitogen-activated protein kinase kinase 7	Homo sapiens	149-152
8125975-2	1994	Following anti-IgM antibody and phorbol 12-myristate 13-acetate (PMA) stimulation, we demonstrate the activation of Ras, Raf-1, and MAPK/ERK kinase (MEK), all of which are thought to participate in an important signaling cascade that leads to MAPK activation.	Tetradecanoylphorbol Acetate	65-68	mitogen-activated protein kinase kinase 7	Homo sapiens	149-152
8125975-5	1994	Similarly, MEK activity toward kinase-active or -inactive recombinant MAPK also increased upon anti-IgM or PMA treatment.	Tetradecanoylphorbol Acetate	107-110	mitogen-activated protein kinase kinase 7	Homo sapiens	11-14
8120067-0	1994	Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.	Tetradecanoylphorbol Acetate	115-151	zinc fingers and homeoboxes 2	Mus musculus	161-164
7917786-6	1994	"PKC-depletion" was achieved by long-term exposure to 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	54-90	protein kinase C, alpha	Mus musculus	1-4
8018556-7	1994	(a) Only PKC-alpha and PKC-epsilon are down-regulated by 12-O-tetradecanoylphorbol-13-acetate whereas PKC-delta and PKC-zeta are not.	Tetradecanoylphorbol Acetate	57-93	protein kinase C, alpha	Mus musculus	9-18
8125155-1	1994	In ground-based studies, activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) also inhibited TNF-mediated killing of LM929 cells.	Tetradecanoylphorbol Acetate	67-98	tumor necrosis factor	Homo sapiens	120-123
8018565-1	1994	Activation of the protein kinase C signaling pathway by tumor-promoting phorbol esters, such as 4 beta-phorbol 12-myristate 13-acetate (PMA), induced a decrease in the level of p53 mRNA in several serum-starved human cell lines.	Tetradecanoylphorbol Acetate	96-134	tumor protein p53	Homo sapiens	177-180
8018565-1	1994	Activation of the protein kinase C signaling pathway by tumor-promoting phorbol esters, such as 4 beta-phorbol 12-myristate 13-acetate (PMA), induced a decrease in the level of p53 mRNA in several serum-starved human cell lines.	Tetradecanoylphorbol Acetate	136-139	tumor protein p53	Homo sapiens	177-180
8018565-7	1994	PMA induced a similar transient decrease in the level of p53 protein in the A549 cell line.	Tetradecanoylphorbol Acetate	0-3	tumor protein p53	Homo sapiens	57-60
7510235-6	1994	These similarities are extended to show that culturing of lpr CD4-CD8- T cells in the presence of IL-2 in combination with phorbol 12-myristate 13-acetate and ionomycin initiates cell cycling and results in the gain of function; re-stimulation now yields IL-2-dependent proliferation in the absence of exogenous IL-2.	Tetradecanoylphorbol Acetate	123-154	Fas (TNF receptor superfamily member 6)	Mus musculus	58-61
8119183-2	1994	To investigate this cAMP-activated gene, we characterized the PTH regulation of tPA messenger RNA (mRNA) in neonatal rat osteoblast cultures before and after differentiation in vitro.	Tetradecanoylphorbol Acetate	80-83	parathyroid hormone	Rattus norvegicus	62-65
8119183-8	1994	The tPA response to PTH was present in first passage osteoblast cultures at confluence and after 1 to 2 weeks of glucocorticoid treatment.	Tetradecanoylphorbol Acetate	4-7	parathyroid hormone	Rattus norvegicus	20-23
8119183-10	1994	In Northern blots of poly(A)+ RNA from cultures not treated with CHX, IBMX and PTH (2.5 h) independently stimulated tPA mRNA with no significant effect on CYP mRNA levels.	Tetradecanoylphorbol Acetate	116-119	parathyroid hormone	Rattus norvegicus	79-82
8119183-11	1994	The tPA/CYP ratio increased in five consecutive experiments and the effect of IBMX and PTH were additive.	Tetradecanoylphorbol Acetate	4-7	parathyroid hormone	Rattus norvegicus	87-90
8119183-12	1994	These data indicate that PTH acts via cAMP to stimulate tPA expression by a mechanism that is independent of protein synthesis.	Tetradecanoylphorbol Acetate	56-59	parathyroid hormone	Rattus norvegicus	25-28
8119183-13	1994	The enhancement of PTH action by CHX is compatible with feedback inhibition of tPA transcription by a hormone-activated repressor (which has been proposed to occur in granulosa cells) but effects of CHX on tPA mRNA stability may also occur.	Tetradecanoylphorbol Acetate	79-82	parathyroid hormone	Rattus norvegicus	19-22
8125155-1	1994	In ground-based studies, activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) also inhibited TNF-mediated killing of LM929 cells.	Tetradecanoylphorbol Acetate	100-103	tumor necrosis factor	Homo sapiens	120-123
8112867-7	1994	TNF-alpha-induced adherence to fibronectin was suppressed from 69% +/- 5% of the phorbol myristate acetate response to 38% +/- 7% (P = 0.0154).	Tetradecanoylphorbol Acetate	81-106	tumor necrosis factor	Homo sapiens	0-9
7908888-13	1994	In contrast, PKC activator, phorbol ester (TPA), caused stronger microtubular assembling in HL-60/ADR, and increased the expression of microtubules to 134%.	Tetradecanoylphorbol Acetate	43-46	proline rich transmembrane protein 2	Homo sapiens	13-16
8120619-6	1994	Simultaneous injection of inositol trisphosphate and superfusion of phorbol 12-myristate 13-acetate reproduced the modulation of the Kv1.5 current.	Tetradecanoylphorbol Acetate	68-99	potassium voltage-gated channel subfamily A member 5	Homo sapiens	133-138
8145543-2	1994	We were particularly interested in the relationship of TNF-alpha binding characteristics to various known neutrophil-priming stimuli such as temperature, N-formylmethionyl-leucyl-phenylalanine (fMLP), phorbol myristate acetate (PMA), C5ades Arg, and human recombinant C5a (HrC5a).	Tetradecanoylphorbol Acetate	228-231	tumor necrosis factor	Homo sapiens	55-64
7517692-6	1994	Secretion of interleukin-2 (IL-2) into the culture media was also detected after stimulation by PHA or TPA, but not in unstimulated cells.	Tetradecanoylphorbol Acetate	103-106	interleukin 2	Homo sapiens	13-26
7517692-6	1994	Secretion of interleukin-2 (IL-2) into the culture media was also detected after stimulation by PHA or TPA, but not in unstimulated cells.	Tetradecanoylphorbol Acetate	103-106	interleukin 2	Homo sapiens	28-32
8113691-4	1994	In vitro release of TGF-beta by unstimulated cultures, or cultures stimulated by antibody to cell surface immunoglobulin (anti-mu) plus phorbol 12-myristate 13-acetate (PMA) was higher in CLL than in normal B cells.	Tetradecanoylphorbol Acetate	136-167	transforming growth factor beta 1	Homo sapiens	20-28
7906722-7	1994	Finally, this action of PRL could be mimicked by 12-O-tetradecanoylphorbol 13-acetate (a direct activator of protein kinase C).	Tetradecanoylphorbol Acetate	49-85	prolactin	Rattus norvegicus	24-27
7906314-0	1994	The phorbol ester phorbol myristate acetate inhibits human immunodeficiency virus type 1 envelope-mediated fusion by modulating an accessory component(s) in CD4-expressing cells.	Tetradecanoylphorbol Acetate	18-43	CD4 molecule	Homo sapiens	157-160
7906314-1	1994	The phorbol ester phorbol myristate acetate (PMA) strongly inhibits human immunodeficiency virus type 1 (HIV-1)-induced syncytium formation; it has been suggested that this inhibitory effect is due to the transient downmodulation of the surface-associated CD4 receptors by PMA (I. H. Chowdhury, Y. Koyanagi, S. Kobayashi, Y. Hamamoto, H. Yoshiyama, T. Yoshida, and N. Yamamoto, Virology 176:126-132, 1990).	Tetradecanoylphorbol Acetate	18-43	CD4 molecule	Homo sapiens	256-259
7906314-1	1994	The phorbol ester phorbol myristate acetate (PMA) strongly inhibits human immunodeficiency virus type 1 (HIV-1)-induced syncytium formation; it has been suggested that this inhibitory effect is due to the transient downmodulation of the surface-associated CD4 receptors by PMA (I. H. Chowdhury, Y. Koyanagi, S. Kobayashi, Y. Hamamoto, H. Yoshiyama, T. Yoshida, and N. Yamamoto, Virology 176:126-132, 1990).	Tetradecanoylphorbol Acetate	45-48	CD4 molecule	Homo sapiens	256-259
7906314-6	1994	The inhibitory effect of PMA was blocked by staurosporine in a dose-dependent fashion, suggesting that it is mediated by protein kinase C. PMA treatment of A2.01.CD4.401 cells reduced the number of infected cells 6.7-fold, as estimated by a quantitative analysis of the HIV-1 MN infection kinetics, probably by affecting the stage of virus entry into cells.	Tetradecanoylphorbol Acetate	25-28	CD4 molecule	Homo sapiens	162-165
8114743-5	1994	We demonstrate that tetradecanoyl phorbol acetate treatment results in a marked and prolonged increase in AP-1 binding activity on these elements, which can be accounted for almost entirely by c-jun and junB.	Tetradecanoylphorbol Acetate	20-49	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-110
8114743-5	1994	We demonstrate that tetradecanoyl phorbol acetate treatment results in a marked and prolonged increase in AP-1 binding activity on these elements, which can be accounted for almost entirely by c-jun and junB.	Tetradecanoylphorbol Acetate	20-49	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	203-207
8112867-7	1994	TNF-alpha-induced adherence to fibronectin was suppressed from 69% +/- 5% of the phorbol myristate acetate response to 38% +/- 7% (P = 0.0154).	Tetradecanoylphorbol Acetate	81-106	fibronectin 1	Homo sapiens	31-42
7907090-4	1994	Four TPA-responsive DNA regions were identified, each containing a potential TPA-responsive enhancer sequence: 1) -677/-340 an AP3-like sequence; 2) -290/278 a TPA-response element (TRE); 3) -227/-175 an NF kappa B-like sequence; 4) -105/-38 an AP2-like sequence.	Tetradecanoylphorbol Acetate	5-8	nuclear factor kappa B subunit 1	Homo sapiens	204-214
8108136-6	1994	While p100 is constitutively localized in the cytoplasm, NF-kappa B induction by TPA treatment of Hela cells is associated with cytoplasmic/nuclear translocation of NFKB-2 p52 and its appearance within DNA-binding NF-kappa B complexes.	Tetradecanoylphorbol Acetate	81-84	nuclear factor kappa B subunit 1	Homo sapiens	57-67
8108136-6	1994	While p100 is constitutively localized in the cytoplasm, NF-kappa B induction by TPA treatment of Hela cells is associated with cytoplasmic/nuclear translocation of NFKB-2 p52 and its appearance within DNA-binding NF-kappa B complexes.	Tetradecanoylphorbol Acetate	81-84	nuclear factor kappa B subunit 2	Homo sapiens	165-171
8108136-6	1994	While p100 is constitutively localized in the cytoplasm, NF-kappa B induction by TPA treatment of Hela cells is associated with cytoplasmic/nuclear translocation of NFKB-2 p52 and its appearance within DNA-binding NF-kappa B complexes.	Tetradecanoylphorbol Acetate	81-84	nuclear factor kappa B subunit 2	Homo sapiens	172-175
8108136-6	1994	While p100 is constitutively localized in the cytoplasm, NF-kappa B induction by TPA treatment of Hela cells is associated with cytoplasmic/nuclear translocation of NFKB-2 p52 and its appearance within DNA-binding NF-kappa B complexes.	Tetradecanoylphorbol Acetate	81-84	nuclear factor kappa B subunit 1	Homo sapiens	214-224
8108142-2	1994	Expression of the VEGF gene can be induced by tumor promoting phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), which activate protein kinase C (PKC).	Tetradecanoylphorbol Acetate	86-122	vascular endothelial growth factor A	Homo sapiens	18-22
8108142-2	1994	Expression of the VEGF gene can be induced by tumor promoting phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), which activate protein kinase C (PKC).	Tetradecanoylphorbol Acetate	124-127	vascular endothelial growth factor A	Homo sapiens	18-22
8108142-5	1994	Mutant p53 specifically increases TPA induction of VEGF without affecting the expression of other TPA inducible genes.	Tetradecanoylphorbol Acetate	34-37	tumor protein p53	Homo sapiens	7-10
8108142-5	1994	Mutant p53 specifically increases TPA induction of VEGF without affecting the expression of other TPA inducible genes.	Tetradecanoylphorbol Acetate	34-37	vascular endothelial growth factor A	Homo sapiens	51-55
8108142-6	1994	TPA dependent VEGF expression is also enhanced by human p53 mutated at amino acid 175.	Tetradecanoylphorbol Acetate	0-3	vascular endothelial growth factor A	Homo sapiens	14-18
8108142-6	1994	TPA dependent VEGF expression is also enhanced by human p53 mutated at amino acid 175.	Tetradecanoylphorbol Acetate	0-3	tumor protein p53	Homo sapiens	56-59
8160360-1	1994	Gamma interferon produced by porcine lymphocytes (nPoIFN gamma) in response to stimulation with phorbol-myristate-acetate (PMA) and phytohemagglutinin (PHA) was monitored by a radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	96-121	interferon gamma	Mus musculus	0-16
8160360-1	1994	Gamma interferon produced by porcine lymphocytes (nPoIFN gamma) in response to stimulation with phorbol-myristate-acetate (PMA) and phytohemagglutinin (PHA) was monitored by a radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	123-126	interferon gamma	Mus musculus	0-16
7907090-7	1994	The newly identified NF kappa B enhancer (TGGAAATTCC) is bound by a TNF alpha-induced nuclear protein and appears to be the key element in rapid transcription induction by TNF alpha (and TPA), while transactivation of this element is repressed by the ligand-bound glucocorticoid receptor.	Tetradecanoylphorbol Acetate	187-190	nuclear factor kappa B subunit 1	Homo sapiens	21-31
7907090-7	1994	The newly identified NF kappa B enhancer (TGGAAATTCC) is bound by a TNF alpha-induced nuclear protein and appears to be the key element in rapid transcription induction by TNF alpha (and TPA), while transactivation of this element is repressed by the ligand-bound glucocorticoid receptor.	Tetradecanoylphorbol Acetate	187-190	tumor necrosis factor	Homo sapiens	68-77
7907090-7	1994	The newly identified NF kappa B enhancer (TGGAAATTCC) is bound by a TNF alpha-induced nuclear protein and appears to be the key element in rapid transcription induction by TNF alpha (and TPA), while transactivation of this element is repressed by the ligand-bound glucocorticoid receptor.	Tetradecanoylphorbol Acetate	187-190	tumor necrosis factor	Homo sapiens	172-181
7907090-7	1994	The newly identified NF kappa B enhancer (TGGAAATTCC) is bound by a TNF alpha-induced nuclear protein and appears to be the key element in rapid transcription induction by TNF alpha (and TPA), while transactivation of this element is repressed by the ligand-bound glucocorticoid receptor.	Tetradecanoylphorbol Acetate	187-190	nuclear receptor subfamily 3 group C member 1	Homo sapiens	264-287
8112299-0	1994	Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.	Tetradecanoylphorbol Acetate	33-36	MAX dimerization protein 3	Homo sapiens	61-65
7515597-5	1994	This method was applied to cloning of a cDNA encoding interleukin 8 (IL-8) from a cDNA library prepared from phorbol myristate acetate-treated U937 cells.	Tetradecanoylphorbol Acetate	109-134	C-X-C motif chemokine ligand 8	Homo sapiens	54-67
7515597-5	1994	This method was applied to cloning of a cDNA encoding interleukin 8 (IL-8) from a cDNA library prepared from phorbol myristate acetate-treated U937 cells.	Tetradecanoylphorbol Acetate	109-134	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
7906937-6	1994	The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 showed almost complete inhibition of the increase in intracellular peroxide levels of the endothelial cells exposed to PMA-stimulated leukocytes.	Tetradecanoylphorbol Acetate	184-187	integrin subunit beta 2	Homo sapiens	48-52
8129736-1	1994	Protein kinase C (PKC), an enzyme which is believed to mediate the stimulatory effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) on phospholipase D (PLD) activity, has a zinc-dependent structure required for phorbol ester binding.	Tetradecanoylphorbol Acetate	108-139	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	149-164
8129736-1	1994	Protein kinase C (PKC), an enzyme which is believed to mediate the stimulatory effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) on phospholipase D (PLD) activity, has a zinc-dependent structure required for phorbol ester binding.	Tetradecanoylphorbol Acetate	108-139	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	166-169
8129736-1	1994	Protein kinase C (PKC), an enzyme which is believed to mediate the stimulatory effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) on phospholipase D (PLD) activity, has a zinc-dependent structure required for phorbol ester binding.	Tetradecanoylphorbol Acetate	141-144	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	149-164
8129736-1	1994	Protein kinase C (PKC), an enzyme which is believed to mediate the stimulatory effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) on phospholipase D (PLD) activity, has a zinc-dependent structure required for phorbol ester binding.	Tetradecanoylphorbol Acetate	141-144	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	166-169
8129736-4	1994	In [14C]palmitic acid-labelled fibroblasts, in the presence of ethanol, phenanthroline also enhanced the stimulatory effect of PMA on the synthesis of phosphatidylethanol, a marker of PLD activity.	Tetradecanoylphorbol Acetate	127-130	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	184-187
8112895-8	1994	Exposure of cells to bryostatin I or TPA for 30 min caused the redistribution of PKCs-alpha and -epsilon from the cytosol to the particulate and nuclear fractions in a concentration-dependent fashion.	Tetradecanoylphorbol Acetate	37-40	protein kinase C alpha	Homo sapiens	81-104
7906679-7	1994	Of the agents which inhibit the growth of T47D and ZR75.1 cells--Pg, Prl, cAMP, RA and TPA--only Pg and cAMP caused an increase in the erbB-2 protein level.	Tetradecanoylphorbol Acetate	87-90	erb-b2 receptor tyrosine kinase 2	Homo sapiens	135-141
8112299-0	1994	Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.	Tetradecanoylphorbol Acetate	33-36	nuclear factor kappa B subunit 1	Homo sapiens	83-93
8112895-2	1994	Like the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) it activates protein kinase C (PKC).	Tetradecanoylphorbol Acetate	39-75	protein kinase C alpha	Homo sapiens	113-116
8112895-2	1994	Like the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) it activates protein kinase C (PKC).	Tetradecanoylphorbol Acetate	77-80	protein kinase C alpha	Homo sapiens	113-116
8308036-5	1994	However, only overproduction of the wild type in transfected cells increases the basal levels and stimulates the secretion of prolactin (PRL) by 12-O-tetradecanoylphorbol-13-acetate or thyrotropin-releasing hormone (TRH).	Tetradecanoylphorbol Acetate	145-181	prolactin	Rattus norvegicus	137-140
8106404-6	1994	Promoter analysis of the CL100 gene indicates that an 800-base pair region flanking the transcriptional initiation site is sufficient to confer a transcriptional response to serum and 12-O-tetradecanoylphorbol-13-acetate stimulation.	Tetradecanoylphorbol Acetate	184-220	dual specificity phosphatase 1	Homo sapiens	25-30
8086278-4	1994	Our results show varying effects of TPA and H-7 on zonula adherens and focal contacts, suggesting differences in modulation of both types of adherens junctions by mechanisms partially involving PKC.	Tetradecanoylphorbol Acetate	36-39	proline rich transmembrane protein 2	Homo sapiens	194-197
8308015-5	1994	Tryptic phosphopeptide analysis of ER, using a two-dimensional peptide mapping procedure, revealed similar patterns for ER in cells treated with estradiol, antiestrogens or TPA; with CT+IBMX treatment, the same phosphopeptides were seen, but the relative phosphorylation of the different ER phosphotryptic peptides differed.	Tetradecanoylphorbol Acetate	173-176	estrogen receptor 1	Homo sapiens	120-122
8308015-5	1994	Tryptic phosphopeptide analysis of ER, using a two-dimensional peptide mapping procedure, revealed similar patterns for ER in cells treated with estradiol, antiestrogens or TPA; with CT+IBMX treatment, the same phosphopeptides were seen, but the relative phosphorylation of the different ER phosphotryptic peptides differed.	Tetradecanoylphorbol Acetate	173-176	estrogen receptor 1	Homo sapiens	120-122
8199014-3	1994	Co-stimulation with A23187 plus PMA resulted in an up-regulation of M-CSF mRNA and a down-regulation of IL-6 mRNA.	Tetradecanoylphorbol Acetate	32-35	interleukin 6	Homo sapiens	104-108
8019487-4	1994	The reported bcl-2 up regulation in malignant lymphoid cells was confirmed in haemo- and lymphopoietic progenitor cells as well as in TPA/PHA activated peripheral blood lymphocytes.	Tetradecanoylphorbol Acetate	134-137	BCL2 apoptosis regulator	Homo sapiens	13-18
8141269-5	1994	Stimulation with ionomycin plus phorbol 12-myristate 13-acetate leads to intracellular alkalinization within 90 min, reaching the more alkaline steady-state value of 7.25 within 7-10 h. Proliferation, but not viability, of lymphocytes is dependent on extracellular pH in the range of 6.4-8.0, and this dependence is not due to limiting interleukin-2 elaboration.	Tetradecanoylphorbol Acetate	32-63	interleukin 2	Homo sapiens	336-349
8298141-3	1994	We have previously shown that uPAR is expressed on the plasma membrane of circulating neutrophils, and we now report that stimulation with phorbol myristate acetate (PMA), FMLP, or tumor necrosis factor-alpha results in a rapid increase in the expression of uPAR.	Tetradecanoylphorbol Acetate	139-164	plasminogen activator, urokinase	Homo sapiens	30-34
8298141-3	1994	We have previously shown that uPAR is expressed on the plasma membrane of circulating neutrophils, and we now report that stimulation with phorbol myristate acetate (PMA), FMLP, or tumor necrosis factor-alpha results in a rapid increase in the expression of uPAR.	Tetradecanoylphorbol Acetate	139-164	formyl peptide receptor 1	Homo sapiens	172-176
8298141-3	1994	We have previously shown that uPAR is expressed on the plasma membrane of circulating neutrophils, and we now report that stimulation with phorbol myristate acetate (PMA), FMLP, or tumor necrosis factor-alpha results in a rapid increase in the expression of uPAR.	Tetradecanoylphorbol Acetate	139-164	tumor necrosis factor	Homo sapiens	181-208
8298141-3	1994	We have previously shown that uPAR is expressed on the plasma membrane of circulating neutrophils, and we now report that stimulation with phorbol myristate acetate (PMA), FMLP, or tumor necrosis factor-alpha results in a rapid increase in the expression of uPAR.	Tetradecanoylphorbol Acetate	139-164	plasminogen activator, urokinase	Homo sapiens	258-262
8298141-3	1994	We have previously shown that uPAR is expressed on the plasma membrane of circulating neutrophils, and we now report that stimulation with phorbol myristate acetate (PMA), FMLP, or tumor necrosis factor-alpha results in a rapid increase in the expression of uPAR.	Tetradecanoylphorbol Acetate	166-169	plasminogen activator, urokinase	Homo sapiens	30-34
8298141-3	1994	We have previously shown that uPAR is expressed on the plasma membrane of circulating neutrophils, and we now report that stimulation with phorbol myristate acetate (PMA), FMLP, or tumor necrosis factor-alpha results in a rapid increase in the expression of uPAR.	Tetradecanoylphorbol Acetate	166-169	plasminogen activator, urokinase	Homo sapiens	258-262
8086278-3	1994	The activity of PKC was influenced by administration of TPA (12-O-tetradecanoylphorbol-13-acetate, a specific PKC activator) and H-7 [1-(5-isoquinolinesulphonyl)-2-methylpiperazine, a PKC inhibitor] for various periods of time.	Tetradecanoylphorbol Acetate	56-59	proline rich transmembrane protein 2	Homo sapiens	16-19
8086278-3	1994	The activity of PKC was influenced by administration of TPA (12-O-tetradecanoylphorbol-13-acetate, a specific PKC activator) and H-7 [1-(5-isoquinolinesulphonyl)-2-methylpiperazine, a PKC inhibitor] for various periods of time.	Tetradecanoylphorbol Acetate	61-97	proline rich transmembrane protein 2	Homo sapiens	16-19
8086278-3	1994	The activity of PKC was influenced by administration of TPA (12-O-tetradecanoylphorbol-13-acetate, a specific PKC activator) and H-7 [1-(5-isoquinolinesulphonyl)-2-methylpiperazine, a PKC inhibitor] for various periods of time.	Tetradecanoylphorbol Acetate	61-97	proline rich transmembrane protein 2	Homo sapiens	110-113
8086278-3	1994	The activity of PKC was influenced by administration of TPA (12-O-tetradecanoylphorbol-13-acetate, a specific PKC activator) and H-7 [1-(5-isoquinolinesulphonyl)-2-methylpiperazine, a PKC inhibitor] for various periods of time.	Tetradecanoylphorbol Acetate	61-97	proline rich transmembrane protein 2	Homo sapiens	110-113
8112326-3	1994	Culture of Mono Mac 6 cells for 24 h with phorbol 12-myristate 13-acetate, bacterial lipopolysaccharide and the cytokines interleukin-1 beta and tumour necrosis factor-alpha enhanced mRNA abundance, with the strongest effect (tenfold) being observed with the lipopolysaccharide.	Tetradecanoylphorbol Acetate	42-73	interleukin 1 beta	Homo sapiens	122-173
8313996-1	1994	The nerve growth factor (NGF)-dependent transdifferentiation of adrenal chromaffin cells into sympathetic neurons occurs in two sequential phases: The first phase, in which cells extend neurites and increase proliferation, is mimicked by phorbol myristate acetate (PMA), an activator of protein kinase C. Analogs of cAMP, and forskolin, an activator of adenylate cyclase, antagonize the early effects of both NGF and PMA.	Tetradecanoylphorbol Acetate	265-268	cathelicidin antimicrobial peptide	Homo sapiens	316-370
8180124-0	1994	Analysis of transforming growth factor beta 1 messenger RNA degradation by the transcript-selective, 12-O-tetradecanoylphorbol-13-acetate-regulated ribonuclease system from U937 promonocytes.	Tetradecanoylphorbol Acetate	101-137	transforming growth factor beta 1	Homo sapiens	12-45
8180124-1	1994	Transforming growth factor (TGF) beta 1 mRNA is selectively stabilized during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of U937 promonocytes.	Tetradecanoylphorbol Acetate	78-114	transforming growth factor beta 1	Homo sapiens	0-39
8180124-1	1994	Transforming growth factor (TGF) beta 1 mRNA is selectively stabilized during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of U937 promonocytes.	Tetradecanoylphorbol Acetate	116-119	transforming growth factor beta 1	Homo sapiens	0-39
8180124-5	1994	The studies reported here were designed to localize domains of TGF-beta 1 mRNA required for recognition by this TPA-regulated, transcript-selective RNase system.	Tetradecanoylphorbol Acetate	112-115	transforming growth factor beta 1	Homo sapiens	63-73
8180124-7	1994	The 5" and 3" untranslated regions of TGF-beta 1 mRNA are also required for TPA-mediated inhibition of the transcript-selective RNase system.	Tetradecanoylphorbol Acetate	76-79	transforming growth factor beta 1	Homo sapiens	38-48
8180129-6	1994	AP-1 binding activity was enhanced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and in a temporally dependent manner, with conversion of a high to low mobility band shift occurring after a 12-h exposure to TPA.	Tetradecanoylphorbol Acetate	38-74	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
8180129-6	1994	AP-1 binding activity was enhanced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and in a temporally dependent manner, with conversion of a high to low mobility band shift occurring after a 12-h exposure to TPA.	Tetradecanoylphorbol Acetate	76-79	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
8180129-6	1994	AP-1 binding activity was enhanced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and in a temporally dependent manner, with conversion of a high to low mobility band shift occurring after a 12-h exposure to TPA.	Tetradecanoylphorbol Acetate	207-210	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
8180129-7	1994	After a 72-h exposure, AP-1 binding activity was maximally increased by 1 nM TPA and remained elevated to a similar degree even after treatment with 600 nM TPA.	Tetradecanoylphorbol Acetate	77-80	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	23-27
8180129-7	1994	After a 72-h exposure, AP-1 binding activity was maximally increased by 1 nM TPA and remained elevated to a similar degree even after treatment with 600 nM TPA.	Tetradecanoylphorbol Acetate	156-159	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	23-27
8180129-8	1994	Enhanced AP-1 binding activity was dependent upon continuous exposure to TPA and was not secondary to differentiation.	Tetradecanoylphorbol Acetate	73-76	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	9-13
8180129-9	1994	A 72-h treatment with one nM TPA maximally increased expression of c-jun, krox-24, and jun-B mRNA transcripts.	Tetradecanoylphorbol Acetate	29-32	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	87-92
7905497-4	1994	We report that prolonged exposure of immunologically naive and unstimulated human neonatal CD4 T cells to IL-4 or to IL-4 plus either IL-2 or IL-12 markedly affects their cytokine production on primary stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	219-222	interleukin 4	Homo sapiens	106-110
8193081-10	1994	Stimulation of NHKs with phorbol 12-myristate 13-acetate(PMA) and lipopolysaccharide(LPS) resulted in an increase of IL-8 and decrease of IL-1 alpha in the culture supernatants.	Tetradecanoylphorbol Acetate	25-56	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
8193081-10	1994	Stimulation of NHKs with phorbol 12-myristate 13-acetate(PMA) and lipopolysaccharide(LPS) resulted in an increase of IL-8 and decrease of IL-1 alpha in the culture supernatants.	Tetradecanoylphorbol Acetate	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
8193081-12	1994	Hydrocortisone and cyclosporin A showed similar inhibitory effects on PMA/LPS-increased IL-8 secretion from NHKs but had little effect of restoring IL-1 alpha.	Tetradecanoylphorbol Acetate	70-73	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
8168869-2	1994	The MAP kinase activity was stimulated by growth factors (FGFb, FGFa, EGF, PDGF, and IGF1), by a phorbol ester (TPA) activating-protein kinase C (PKC), by a neuropeptide (endothelin-1), and by a neuromediator (carbachol).	Tetradecanoylphorbol Acetate	112-115	endothelin 1	Rattus norvegicus	171-183
8168869-3	1994	Astrocytes pretreated for 18 h with TPA were still stimulated by growth factors and endothelin, suggesting that down-regulated isoforms of PKC are not involved in MAP kinase activation.	Tetradecanoylphorbol Acetate	36-39	endothelin 1	Rattus norvegicus	84-94
7905497-4	1994	We report that prolonged exposure of immunologically naive and unstimulated human neonatal CD4 T cells to IL-4 or to IL-4 plus either IL-2 or IL-12 markedly affects their cytokine production on primary stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	219-222	CD4 molecule	Homo sapiens	91-94
7905497-4	1994	We report that prolonged exposure of immunologically naive and unstimulated human neonatal CD4 T cells to IL-4 or to IL-4 plus either IL-2 or IL-12 markedly affects their cytokine production on primary stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	219-222	interleukin 4	Homo sapiens	117-121
7905497-4	1994	We report that prolonged exposure of immunologically naive and unstimulated human neonatal CD4 T cells to IL-4 or to IL-4 plus either IL-2 or IL-12 markedly affects their cytokine production on primary stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	219-222	interleukin 2	Homo sapiens	134-138
7905497-7	1994	In response to primary stimulation with PMA and ionomycin, cells primed with IL-4 + IL-2 produce IL-4, IL-5, and IL-10 and the same levels of IL-2 and IFN-gamma as IL-4-primed cells.	Tetradecanoylphorbol Acetate	40-43	interleukin 4	Homo sapiens	77-81
7905497-7	1994	In response to primary stimulation with PMA and ionomycin, cells primed with IL-4 + IL-2 produce IL-4, IL-5, and IL-10 and the same levels of IL-2 and IFN-gamma as IL-4-primed cells.	Tetradecanoylphorbol Acetate	40-43	interleukin 2	Homo sapiens	84-88
8294914-8	1994	Histamine also caused a massive release of arachidonic acid, which occurred in a Ca(2+)- and PMA-sensitive manner, probably through the activation of a cytosolic phospholipase A2, which partly involves coupling to a PTX-sensitive G protein.	Tetradecanoylphorbol Acetate	93-96	cytosolic phospholipase A2	Cricetulus griseus	152-178
7905497-7	1994	In response to primary stimulation with PMA and ionomycin, cells primed with IL-4 + IL-2 produce IL-4, IL-5, and IL-10 and the same levels of IL-2 and IFN-gamma as IL-4-primed cells.	Tetradecanoylphorbol Acetate	40-43	interleukin 4	Homo sapiens	97-101
7905497-7	1994	In response to primary stimulation with PMA and ionomycin, cells primed with IL-4 + IL-2 produce IL-4, IL-5, and IL-10 and the same levels of IL-2 and IFN-gamma as IL-4-primed cells.	Tetradecanoylphorbol Acetate	40-43	interleukin 2	Homo sapiens	142-146
7905497-7	1994	In response to primary stimulation with PMA and ionomycin, cells primed with IL-4 + IL-2 produce IL-4, IL-5, and IL-10 and the same levels of IL-2 and IFN-gamma as IL-4-primed cells.	Tetradecanoylphorbol Acetate	40-43	interferon gamma	Homo sapiens	151-160
7905497-7	1994	In response to primary stimulation with PMA and ionomycin, cells primed with IL-4 + IL-2 produce IL-4, IL-5, and IL-10 and the same levels of IL-2 and IFN-gamma as IL-4-primed cells.	Tetradecanoylphorbol Acetate	40-43	interleukin 4	Homo sapiens	97-101
7905499-6	1994	Stimulation of transfected T cells with the mitogen Con A, anti-CD3 Ab, or PMA plus ionomycin activated the IL2ZH construct in Th1 but not Th2 cells.	Tetradecanoylphorbol Acetate	75-78	negative elongation factor complex member C/D, Th1l	Mus musculus	127-130
7507205-3	1994	DIF DNA binding was activated by colony-stimulating factor 1 in murine macrophages and also during tetradecanoyl phorbol acetate-induced differentiation or IFN-gamma treatment in myeloid U937 cells.	Tetradecanoylphorbol Acetate	99-128	tumor necrosis factor	Mus musculus	0-3
8126384-7	1994	Cycloheximide and actinomycin D completely abolished PMA-stimulated t-PA secretion.	Tetradecanoylphorbol Acetate	53-56	plasminogen activator, tissue type	Homo sapiens	68-72
8186319-6	1994	Treatment with TPA for 48 h induced expression of IL-1 beta mRNA, an effect that was enhanced two fold by LPS.	Tetradecanoylphorbol Acetate	15-18	interleukin 1 beta	Homo sapiens	50-59
8289787-4	1994	Ablation of epidermal growth factor-, tetradecanoyl phorbol acetate-, or anisomycin-stimulated S6 phosphorylation by using the p70/85S6k inhibitor rapamycin has no effect on histone H3 and HMG-like protein phosphorylation or on the induction and superinduction of c-fos and c-jun.	Tetradecanoylphorbol Acetate	38-67	ubiquitin associated and SH3 domain containing B	Homo sapiens	127-136
8286412-0	1994	Site-directed mutagenesis of the synthetic Erythrina trypsin/tissue plasminogen activator (tPA) inhibitor encoding-gene to compare the interaction of Erythrina and soybean trypsin inhibitor with tPA.	Tetradecanoylphorbol Acetate	195-198	kunitz trypsin protease inhibitor	Glycine max	172-189
8202627-1	1994	In human fibroblast cultures TPA increased IL-6 and IL-8 production.	Tetradecanoylphorbol Acetate	29-32	interleukin 6	Homo sapiens	43-47
8202627-1	1994	In human fibroblast cultures TPA increased IL-6 and IL-8 production.	Tetradecanoylphorbol Acetate	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
7506954-2	1994	We investigated the ability of phorbol myristate acetate (PMA) to stimulate the human promyelocytic cell line HL-60 to adhere to fibronectin, either in its undifferentiated state (HL60) or after dimethylsulfoxide-induced differentiation along the granulocytic pathway (dHL60).	Tetradecanoylphorbol Acetate	31-56	fibronectin 1	Homo sapiens	129-140
7506954-2	1994	We investigated the ability of phorbol myristate acetate (PMA) to stimulate the human promyelocytic cell line HL-60 to adhere to fibronectin, either in its undifferentiated state (HL60) or after dimethylsulfoxide-induced differentiation along the granulocytic pathway (dHL60).	Tetradecanoylphorbol Acetate	58-61	fibronectin 1	Homo sapiens	129-140
8297347-6	1994	Phorbol 12-myristate 13-acetate/ionomycin-induced increases in both hNRP mRNA and mitogenesis, as measured by thymidine incorporation, were markedly inhibited, however, in cells treated with an hNRP antisense oligonucleotide.	Tetradecanoylphorbol Acetate	0-31	nucleosome assembly protein 1 like 1	Homo sapiens	68-72
8286746-1	1994	Treatment of human HL-60 leukemic cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with activation of protein kinase C (PKC) and induction of monocytic differentiation.	Tetradecanoylphorbol Acetate	45-81	protein kinase C alpha	Homo sapiens	139-142
8286746-1	1994	Treatment of human HL-60 leukemic cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with activation of protein kinase C (PKC) and induction of monocytic differentiation.	Tetradecanoylphorbol Acetate	83-86	protein kinase C alpha	Homo sapiens	139-142
8286746-5	1994	In order to measure PKC expression associated with the reversal of TPA resistance by ATRA, we exposed HL-525 cells to ATRA and analyzed PKC-mRNA and protein levels.	Tetradecanoylphorbol Acetate	67-70	protein kinase C alpha	Homo sapiens	20-23
8286746-8	1994	These findings are consistent with the hypothesis that ATRA reverses TPA resistance in HL-525 cells by enhancing the expression of PKC.	Tetradecanoylphorbol Acetate	69-72	protein kinase C alpha	Homo sapiens	131-134
8297347-6	1994	Phorbol 12-myristate 13-acetate/ionomycin-induced increases in both hNRP mRNA and mitogenesis, as measured by thymidine incorporation, were markedly inhibited, however, in cells treated with an hNRP antisense oligonucleotide.	Tetradecanoylphorbol Acetate	0-31	nucleosome assembly protein 1 like 1	Homo sapiens	194-198
8297348-6	1994	Prolonged (48 h) exposure of cells to the phorbol ester phorbol 12-myristate 13-acetate (PMA; 100 nM) resulted in a marked decrease in the amounts of PKC-alpha and PKC-epsilon, with no change in levels of PKC-zeta.	Tetradecanoylphorbol Acetate	56-87	protein kinase C alpha	Homo sapiens	150-159
8297348-6	1994	Prolonged (48 h) exposure of cells to the phorbol ester phorbol 12-myristate 13-acetate (PMA; 100 nM) resulted in a marked decrease in the amounts of PKC-alpha and PKC-epsilon, with no change in levels of PKC-zeta.	Tetradecanoylphorbol Acetate	89-92	protein kinase C alpha	Homo sapiens	150-159
8314307-5	1994	On the other hand, treatment of parental and TPA-resistant SK-Mel 173 cells with TPA led to partial down-regulation of PKC alpha in both cell lines.	Tetradecanoylphorbol Acetate	81-84	protein kinase C alpha	Homo sapiens	119-128
8314307-1	1994	In vitro growth of 6 human melanoma-derived cell lines was inhibited markedly by the phorbol-ester tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA), a potent activator of several isoforms of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	114-151	protein kinase C alpha	Homo sapiens	219-222
8314307-6	1994	Total PKC enzyme activity was also greater in TPA-resistant cells than in parental SK-Mel 173 cells.	Tetradecanoylphorbol Acetate	46-49	protein kinase C alpha	Homo sapiens	6-9
8314307-1	1994	In vitro growth of 6 human melanoma-derived cell lines was inhibited markedly by the phorbol-ester tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA), a potent activator of several isoforms of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	153-156	protein kinase C alpha	Homo sapiens	219-222
8314307-7	1994	Our results show that TPA might inhibit the growth of melanoma cells by causing down-regulation of specific isoforms of PKC that are required to maintain the growth of these cells.	Tetradecanoylphorbol Acetate	22-25	protein kinase C alpha	Homo sapiens	120-123
8314307-5	1994	On the other hand, treatment of parental and TPA-resistant SK-Mel 173 cells with TPA led to partial down-regulation of PKC alpha in both cell lines.	Tetradecanoylphorbol Acetate	45-48	protein kinase C alpha	Homo sapiens	119-128
8140272-8	1994	Peritoneal cells incubated with GRP experimented an increase in PKC activity to the same extent of that produced by the PKC activator phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	134-159	gastrin releasing peptide	Mus musculus	32-35
8140272-8	1994	Peritoneal cells incubated with GRP experimented an increase in PKC activity to the same extent of that produced by the PKC activator phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	161-164	gastrin releasing peptide	Mus musculus	32-35
8304411-3	1994	Exposure of IFN-primed macrophages to polyinosinic-polycytidylic acid in the presence of the PKC inhibitors H-7 or sphingosine or after downregulation of PKC with phorbol myristate acetate markedly inhibited Bf synthesis.	Tetradecanoylphorbol Acetate	163-188	interferon alpha 1	Homo sapiens	12-15
7942278-2	1994	Expression of Ha-ras by dexamethasone leads to a transcriptional activation of the fos-CAT construct which was found to be sensitive to the PKC inhibitor ilmofosine (BM41440) and abrogated by PKC depletion following long-term exposure to TPA.	Tetradecanoylphorbol Acetate	238-241	protein kinase C alpha	Homo sapiens	140-143
7942278-2	1994	Expression of Ha-ras by dexamethasone leads to a transcriptional activation of the fos-CAT construct which was found to be sensitive to the PKC inhibitor ilmofosine (BM41440) and abrogated by PKC depletion following long-term exposure to TPA.	Tetradecanoylphorbol Acetate	238-241	protein kinase C alpha	Homo sapiens	192-195
7942278-5	1994	Transcriptional activation of the SRE-FAP-TK-CAT as well as the SRE-TK-CAT constructs by Ha-ras is sensitive to the PKC-inhibitor ilmofosine (BM41440) and blocked by long-term exposure to TPA.	Tetradecanoylphorbol Acetate	188-191	protein kinase C alpha	Homo sapiens	116-119
7942278-6	1994	Long-term exposure to TPA depletes cells of PKC alpha and significantly reduces the PKC epsilon levels.	Tetradecanoylphorbol Acetate	22-25	protein kinase C alpha	Homo sapiens	44-53
8304487-4	1994	The treatment of GEN with 10(-7) M 12-O-tetradecanoylphorbol-13-acetate (TPA) increased the VEGF mRNA abundance fivefold, supporting the idea that VEGF expression is regulated by protein kinase C. [3H]thymidine incorporation into GEN treated with TPA (10(-7) M) was inhibited by neutralizing antibody for VEGF.	Tetradecanoylphorbol Acetate	35-71	vascular endothelial growth factor A	Homo sapiens	92-96
8304487-4	1994	The treatment of GEN with 10(-7) M 12-O-tetradecanoylphorbol-13-acetate (TPA) increased the VEGF mRNA abundance fivefold, supporting the idea that VEGF expression is regulated by protein kinase C. [3H]thymidine incorporation into GEN treated with TPA (10(-7) M) was inhibited by neutralizing antibody for VEGF.	Tetradecanoylphorbol Acetate	35-71	vascular endothelial growth factor A	Homo sapiens	147-151
8304487-4	1994	The treatment of GEN with 10(-7) M 12-O-tetradecanoylphorbol-13-acetate (TPA) increased the VEGF mRNA abundance fivefold, supporting the idea that VEGF expression is regulated by protein kinase C. [3H]thymidine incorporation into GEN treated with TPA (10(-7) M) was inhibited by neutralizing antibody for VEGF.	Tetradecanoylphorbol Acetate	35-71	vascular endothelial growth factor A	Homo sapiens	147-151
8304487-4	1994	The treatment of GEN with 10(-7) M 12-O-tetradecanoylphorbol-13-acetate (TPA) increased the VEGF mRNA abundance fivefold, supporting the idea that VEGF expression is regulated by protein kinase C. [3H]thymidine incorporation into GEN treated with TPA (10(-7) M) was inhibited by neutralizing antibody for VEGF.	Tetradecanoylphorbol Acetate	73-76	vascular endothelial growth factor A	Homo sapiens	92-96
8304487-4	1994	The treatment of GEN with 10(-7) M 12-O-tetradecanoylphorbol-13-acetate (TPA) increased the VEGF mRNA abundance fivefold, supporting the idea that VEGF expression is regulated by protein kinase C. [3H]thymidine incorporation into GEN treated with TPA (10(-7) M) was inhibited by neutralizing antibody for VEGF.	Tetradecanoylphorbol Acetate	73-76	vascular endothelial growth factor A	Homo sapiens	147-151
8304487-4	1994	The treatment of GEN with 10(-7) M 12-O-tetradecanoylphorbol-13-acetate (TPA) increased the VEGF mRNA abundance fivefold, supporting the idea that VEGF expression is regulated by protein kinase C. [3H]thymidine incorporation into GEN treated with TPA (10(-7) M) was inhibited by neutralizing antibody for VEGF.	Tetradecanoylphorbol Acetate	73-76	vascular endothelial growth factor A	Homo sapiens	147-151
8294465-0	1994	Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts.	Tetradecanoylphorbol Acetate	73-104	proline rich transmembrane protein 2	Homo sapiens	27-43
8294465-1	1994	Bryostatin 1 and phorbol 12-myristate 13-acetate (PMA) are both potent activators of protein kinase C (PKC), although in many systems bryostatin 1 induces only a subset of the responses to PMA and blocks those which it does not induce.	Tetradecanoylphorbol Acetate	17-48	proline rich transmembrane protein 2	Homo sapiens	85-101
8294465-1	1994	Bryostatin 1 and phorbol 12-myristate 13-acetate (PMA) are both potent activators of protein kinase C (PKC), although in many systems bryostatin 1 induces only a subset of the responses to PMA and blocks those which it does not induce.	Tetradecanoylphorbol Acetate	17-48	proline rich transmembrane protein 2	Homo sapiens	103-106
8294465-1	1994	Bryostatin 1 and phorbol 12-myristate 13-acetate (PMA) are both potent activators of protein kinase C (PKC), although in many systems bryostatin 1 induces only a subset of the responses to PMA and blocks those which it does not induce.	Tetradecanoylphorbol Acetate	50-53	proline rich transmembrane protein 2	Homo sapiens	85-101
8294465-1	1994	Bryostatin 1 and phorbol 12-myristate 13-acetate (PMA) are both potent activators of protein kinase C (PKC), although in many systems bryostatin 1 induces only a subset of the responses to PMA and blocks those which it does not induce.	Tetradecanoylphorbol Acetate	50-53	proline rich transmembrane protein 2	Homo sapiens	103-106
8304417-2	1994	The ability of bFGF and 12-O-tetradecanoylphorbol-13-acetate (TPA) to stimulate PLD activity was completely abolished in cells pretreated with 400 nM TPA for 48 h to downregulate protein kinase C (PKC).	Tetradecanoylphorbol Acetate	24-60	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	80-83
8304417-2	1994	The ability of bFGF and 12-O-tetradecanoylphorbol-13-acetate (TPA) to stimulate PLD activity was completely abolished in cells pretreated with 400 nM TPA for 48 h to downregulate protein kinase C (PKC).	Tetradecanoylphorbol Acetate	62-65	fibroblast growth factor 2	Homo sapiens	15-19
8304487-4	1994	The treatment of GEN with 10(-7) M 12-O-tetradecanoylphorbol-13-acetate (TPA) increased the VEGF mRNA abundance fivefold, supporting the idea that VEGF expression is regulated by protein kinase C. [3H]thymidine incorporation into GEN treated with TPA (10(-7) M) was inhibited by neutralizing antibody for VEGF.	Tetradecanoylphorbol Acetate	247-250	vascular endothelial growth factor A	Homo sapiens	92-96
8304487-4	1994	The treatment of GEN with 10(-7) M 12-O-tetradecanoylphorbol-13-acetate (TPA) increased the VEGF mRNA abundance fivefold, supporting the idea that VEGF expression is regulated by protein kinase C. [3H]thymidine incorporation into GEN treated with TPA (10(-7) M) was inhibited by neutralizing antibody for VEGF.	Tetradecanoylphorbol Acetate	247-250	vascular endothelial growth factor A	Homo sapiens	147-151
8280102-1	1994	Phospholipase A2 (PLA2) inhibitors suppressed simultaneously, in a dose-dependent manner, the activation of NADPH oxidase and the release of 3H-labelled arachidonic acid ([3H]AA) stimulated by either phorbol 12-myristate 13-acetate (PMA) or opsonized zymosan (OZ) in human neutrophils.	Tetradecanoylphorbol Acetate	200-231	phospholipase A2 group IB	Homo sapiens	0-16
8304487-4	1994	The treatment of GEN with 10(-7) M 12-O-tetradecanoylphorbol-13-acetate (TPA) increased the VEGF mRNA abundance fivefold, supporting the idea that VEGF expression is regulated by protein kinase C. [3H]thymidine incorporation into GEN treated with TPA (10(-7) M) was inhibited by neutralizing antibody for VEGF.	Tetradecanoylphorbol Acetate	247-250	vascular endothelial growth factor A	Homo sapiens	147-151
8304487-6	1994	Its physiological role might be the regulation of GEN proliferation, and the induction of VEGF expression by FBS and TPA suggests its involvement in the response of glomerular capillary endothelial cells to injury in certain pathophysiological states.	Tetradecanoylphorbol Acetate	117-120	vascular endothelial growth factor A	Homo sapiens	90-94
8280102-2	1994	In spite of total inhibition of superoxide production in the presence of the PLA2 inhibitors, 10 microM bromophenacyl bromide (BPB) or 20 microM quinacrine, a maximal phosphorylation of p47 and translocation of p47 and p67 to the neutrophil membranes induced by PMA or OZ was observed.	Tetradecanoylphorbol Acetate	262-265	phospholipase A2 group IB	Homo sapiens	77-81
8304417-2	1994	The ability of bFGF and 12-O-tetradecanoylphorbol-13-acetate (TPA) to stimulate PLD activity was completely abolished in cells pretreated with 400 nM TPA for 48 h to downregulate protein kinase C (PKC).	Tetradecanoylphorbol Acetate	62-65	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	80-83
8304417-2	1994	The ability of bFGF and 12-O-tetradecanoylphorbol-13-acetate (TPA) to stimulate PLD activity was completely abolished in cells pretreated with 400 nM TPA for 48 h to downregulate protein kinase C (PKC).	Tetradecanoylphorbol Acetate	150-153	fibroblast growth factor 2	Homo sapiens	15-19
8304417-2	1994	The ability of bFGF and 12-O-tetradecanoylphorbol-13-acetate (TPA) to stimulate PLD activity was completely abolished in cells pretreated with 400 nM TPA for 48 h to downregulate protein kinase C (PKC).	Tetradecanoylphorbol Acetate	150-153	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	80-83
7864662-8	1994	Treatment with 10 nM TPA, which also induces keratinocyte differentiation, reduced c-myc RNA levels to 70% of control levels during the first 4 h, but thereafter c-myc levels remained approximately constant for a further 20 h. TGF beta (2 ng/ml), which inhibits keratinocyte growth without inducing differentiation, did not alter c-myc RNA levels over a 4-day period.	Tetradecanoylphorbol Acetate	21-24	transforming growth factor beta 1	Homo sapiens	227-235
8280102-1	1994	Phospholipase A2 (PLA2) inhibitors suppressed simultaneously, in a dose-dependent manner, the activation of NADPH oxidase and the release of 3H-labelled arachidonic acid ([3H]AA) stimulated by either phorbol 12-myristate 13-acetate (PMA) or opsonized zymosan (OZ) in human neutrophils.	Tetradecanoylphorbol Acetate	200-231	phospholipase A2 group IB	Homo sapiens	18-22
8280102-1	1994	Phospholipase A2 (PLA2) inhibitors suppressed simultaneously, in a dose-dependent manner, the activation of NADPH oxidase and the release of 3H-labelled arachidonic acid ([3H]AA) stimulated by either phorbol 12-myristate 13-acetate (PMA) or opsonized zymosan (OZ) in human neutrophils.	Tetradecanoylphorbol Acetate	233-236	phospholipase A2 group IB	Homo sapiens	0-16
8280102-1	1994	Phospholipase A2 (PLA2) inhibitors suppressed simultaneously, in a dose-dependent manner, the activation of NADPH oxidase and the release of 3H-labelled arachidonic acid ([3H]AA) stimulated by either phorbol 12-myristate 13-acetate (PMA) or opsonized zymosan (OZ) in human neutrophils.	Tetradecanoylphorbol Acetate	233-236	phospholipase A2 group IB	Homo sapiens	18-22
7905817-0	1994	Modulation of EGF receptor and CD15 (Lewisx) antigen on the cell surface of breast carcinoma cell lines induced by cytokines, retinoic acid, 12-O-tetradecanoylphorbol 13-acetate and 1,25(OH)2-vitamin D3.	Tetradecanoylphorbol Acetate	141-177	epidermal growth factor receptor	Homo sapiens	14-26
8287495-0	1994	12-O-tetradecanoylphorbol 13-acetate stimulates human T-lymphocyte adherence to the fibronectin RGD domain and the laminin IKVAV domain.	Tetradecanoylphorbol Acetate	0-36	fibronectin 1	Homo sapiens	84-95
8287495-8	1994	These data demonstrate that TPA activates T-cell adherence to laminin and to fibronectin via specific sites on each protein and that this adhesion may be associated with integrin phosphorylation.	Tetradecanoylphorbol Acetate	28-31	fibronectin 1	Homo sapiens	77-88
8123597-3	1994	p26 mJUN was able to block both 12-O-tetradecanoylphorbol-13-acetate (TPA) and okadaic acid induced expression of the mouse stromelysin gene in 10Gy5 cells and TPA induced expression of the urokinase-type plasminogen activator gene in PDV cells as determined by Northern analyses.	Tetradecanoylphorbol Acetate	32-68	transmembrane p24 trafficking protein 4	Mus musculus	0-3
8123597-3	1994	p26 mJUN was able to block both 12-O-tetradecanoylphorbol-13-acetate (TPA) and okadaic acid induced expression of the mouse stromelysin gene in 10Gy5 cells and TPA induced expression of the urokinase-type plasminogen activator gene in PDV cells as determined by Northern analyses.	Tetradecanoylphorbol Acetate	70-73	transmembrane p24 trafficking protein 4	Mus musculus	0-3
8123597-3	1994	p26 mJUN was able to block both 12-O-tetradecanoylphorbol-13-acetate (TPA) and okadaic acid induced expression of the mouse stromelysin gene in 10Gy5 cells and TPA induced expression of the urokinase-type plasminogen activator gene in PDV cells as determined by Northern analyses.	Tetradecanoylphorbol Acetate	160-163	transmembrane p24 trafficking protein 4	Mus musculus	0-3
7905817-0	1994	Modulation of EGF receptor and CD15 (Lewisx) antigen on the cell surface of breast carcinoma cell lines induced by cytokines, retinoic acid, 12-O-tetradecanoylphorbol 13-acetate and 1,25(OH)2-vitamin D3.	Tetradecanoylphorbol Acetate	141-177	fucosyltransferase 4	Homo sapiens	31-35
7905817-3	1994	12-O-tetradecanoylphorbol 13-acetate (TPA) induced up-regulation of EGF receptor on MDA-MB-468 cells, and a marginal but significant increase was determined in BT-20 cells and in interferon gamma (IFN-gamma)-treated MDA-MB-468 cells.	Tetradecanoylphorbol Acetate	0-36	epidermal growth factor receptor	Homo sapiens	68-80
7905817-3	1994	12-O-tetradecanoylphorbol 13-acetate (TPA) induced up-regulation of EGF receptor on MDA-MB-468 cells, and a marginal but significant increase was determined in BT-20 cells and in interferon gamma (IFN-gamma)-treated MDA-MB-468 cells.	Tetradecanoylphorbol Acetate	0-36	interferon gamma	Homo sapiens	179-206
7905817-3	1994	12-O-tetradecanoylphorbol 13-acetate (TPA) induced up-regulation of EGF receptor on MDA-MB-468 cells, and a marginal but significant increase was determined in BT-20 cells and in interferon gamma (IFN-gamma)-treated MDA-MB-468 cells.	Tetradecanoylphorbol Acetate	38-41	epidermal growth factor receptor	Homo sapiens	68-80
7905817-3	1994	12-O-tetradecanoylphorbol 13-acetate (TPA) induced up-regulation of EGF receptor on MDA-MB-468 cells, and a marginal but significant increase was determined in BT-20 cells and in interferon gamma (IFN-gamma)-treated MDA-MB-468 cells.	Tetradecanoylphorbol Acetate	38-41	interferon gamma	Homo sapiens	179-206
7905817-4	1994	CD15 (Lewisx) antigen was down-regulated on MDA-MB-468 cells by TNF-alpha, TPA, IL-1 alpha, as well as by IFN-gamma and all-trans-retinoic acid.	Tetradecanoylphorbol Acetate	75-78	fucosyltransferase 4	Homo sapiens	0-4
7505212-7	1994	We also demonstrated that phorbol 12-myristate 13-acetate (PMA) or triggering of the CD28 molecule is an effective helper signal for IL-6 production by anti-CD3-stimulated T cells.	Tetradecanoylphorbol Acetate	26-57	interleukin 6	Homo sapiens	133-137
7505212-7	1994	We also demonstrated that phorbol 12-myristate 13-acetate (PMA) or triggering of the CD28 molecule is an effective helper signal for IL-6 production by anti-CD3-stimulated T cells.	Tetradecanoylphorbol Acetate	59-62	interleukin 6	Homo sapiens	133-137
8003628-2	1994	As incubation of lymphocytes with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) prior to mitogenic stimulation results in decreased levels of IL-2 mRNA, we asked if IL-2 mRNA stability was affected.	Tetradecanoylphorbol Acetate	52-88	interleukin 2	Homo sapiens	157-161
8287610-8	1994	Although secretion of IFN-gamma after stimulation with phorbol myristate acetate (PMA)/Ca was significantly lower in children with atopic dermatitis compared with controls, the percentage of IFN-gamma-producing cells in the stimulated cultures from this group was equivalent to controls.	Tetradecanoylphorbol Acetate	55-80	interferon gamma	Homo sapiens	22-31
8287610-8	1994	Although secretion of IFN-gamma after stimulation with phorbol myristate acetate (PMA)/Ca was significantly lower in children with atopic dermatitis compared with controls, the percentage of IFN-gamma-producing cells in the stimulated cultures from this group was equivalent to controls.	Tetradecanoylphorbol Acetate	82-85	interferon gamma	Homo sapiens	22-31
8003628-2	1994	As incubation of lymphocytes with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) prior to mitogenic stimulation results in decreased levels of IL-2 mRNA, we asked if IL-2 mRNA stability was affected.	Tetradecanoylphorbol Acetate	90-93	interleukin 2	Homo sapiens	157-161
8003628-3	1994	We found that in TPA-treated cells, IL-2 mRNA was degraded more rapidly than in untreated ones whether the mitogenic stimulus was Concanavalin A (Con A), Con A plus TPA, or TPA plus ionomycin.	Tetradecanoylphorbol Acetate	17-20	interleukin 2	Homo sapiens	36-40
8003628-3	1994	We found that in TPA-treated cells, IL-2 mRNA was degraded more rapidly than in untreated ones whether the mitogenic stimulus was Concanavalin A (Con A), Con A plus TPA, or TPA plus ionomycin.	Tetradecanoylphorbol Acetate	165-168	interleukin 2	Homo sapiens	36-40
8003628-3	1994	We found that in TPA-treated cells, IL-2 mRNA was degraded more rapidly than in untreated ones whether the mitogenic stimulus was Concanavalin A (Con A), Con A plus TPA, or TPA plus ionomycin.	Tetradecanoylphorbol Acetate	165-168	interleukin 2	Homo sapiens	36-40
8003628-5	1994	In contrast, when TPA was included as a co-mitogen, i.e. added at the same time as the mitogen, the IL-2 mRNA levels and stability significantly increased.	Tetradecanoylphorbol Acetate	18-21	interleukin 2	Homo sapiens	100-104
8003628-6	1994	Compared to the levels found in Con A stimulated cells, TPA plus Con A increased IL-2 mRNA levels by as much as 20-fold and the half-life by 5-fold.	Tetradecanoylphorbol Acetate	56-59	interleukin 2	Homo sapiens	81-85
8175909-9	1994	In addition, we have demonstrated that the common melanocyte mitogens 12-O-tetradecanoyl phorbol-13-acetate (TPA) and cholera toxin affect basal melanogenesis and modulate the effects of the MSH peptides.	Tetradecanoylphorbol Acetate	70-107	proopiomelanocortin	Homo sapiens	191-194
8281849-6	1994	At the cellular level, 5-aminosalicylic acid inhibited phorbol myristate acetate (100 ng/ml)-activated superoxide generation to 82.3 +/- 9.3%, the formylmethionyl leucyl peptide (10(-5) M) to 61.0 +/- 6.8%, and the NaF (20 mM)-stimulated production to 32.3 +/- 3.2% (mean +/- SD, P &lt; 0.01).	Tetradecanoylphorbol Acetate	55-80	C-X-C motif chemokine ligand 8	Homo sapiens	215-218
7960600-2	1994	Like the phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate (TPA) it directly activates the calcium- and phospholipid-dependent protein kinase C (PKC), thus generating a number of different cellular responses.	Tetradecanoylphorbol Acetate	23-60	plasminogen activator, tissue type	Homo sapiens	62-65
7807282-6	1994	Whereas all activators induced significant IFN-gamma secretion, only ionomycin plus PMA stimulation induced large IL-4 secretion.	Tetradecanoylphorbol Acetate	84-87	interleukin 4	Homo sapiens	114-118
8175909-9	1994	In addition, we have demonstrated that the common melanocyte mitogens 12-O-tetradecanoyl phorbol-13-acetate (TPA) and cholera toxin affect basal melanogenesis and modulate the effects of the MSH peptides.	Tetradecanoylphorbol Acetate	109-112	proopiomelanocortin	Homo sapiens	191-194
7577367-6	1994	C/EBP isoforms inhibited the phorbol 12-myristate 13-acetate (PMA)-stimulated HIV-1 promoter activity in human glioblastoma U138MG and neuroblastoma SHSY5Y cells, but not in HeLa epithelial cells, and this inhibition required the NF-kappa B element.	Tetradecanoylphorbol Acetate	29-60	CCAAT enhancer binding protein alpha	Homo sapiens	0-5
8254739-4	1994	We show by in situ hybridization of mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) that VL30 expression is induced in epidermal keratinocytes but not in dermal fibroblasts.	Tetradecanoylphorbol Acetate	60-96	RIKEN cDNA A130040M12 gene	Mus musculus	108-112
8254739-4	1994	We show by in situ hybridization of mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) that VL30 expression is induced in epidermal keratinocytes but not in dermal fibroblasts.	Tetradecanoylphorbol Acetate	98-101	RIKEN cDNA A130040M12 gene	Mus musculus	108-112
8254739-5	1994	Transient transfections of reporter gene plasmids together with in vitro binding analysis indicate that TPA-induced VL30 transcription specific for keratinocytes is mediated by two cooperating sequence motifs in juxtaposed position.	Tetradecanoylphorbol Acetate	104-107	RIKEN cDNA A130040M12 gene	Mus musculus	116-120
8254739-6	1994	One sequence motif is shown to constitutively bind CREB- and Jun-related proteins in both keratinocytes and fibroblasts, whereas the other is a target for TPA-induced c-Rel/p65(NF-kappa B)-binding activity specifically in keratinocytes.	Tetradecanoylphorbol Acetate	155-158	cAMP responsive element binding protein 1	Mus musculus	51-56
8254739-6	1994	One sequence motif is shown to constitutively bind CREB- and Jun-related proteins in both keratinocytes and fibroblasts, whereas the other is a target for TPA-induced c-Rel/p65(NF-kappa B)-binding activity specifically in keratinocytes.	Tetradecanoylphorbol Acetate	155-158	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	177-187
8107527-2	1994	Our results show that mouse ear inflammation induced by CO, AA or TPA is decreased by topical administration of CGRP, whereas that induced by CA is not affected.	Tetradecanoylphorbol Acetate	66-69	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	112-116
8028395-8	1994	After peripheral blood lymphocyte stimulation, Cu/Zn SOD concentration was higher than levels in unstimulated cells, both in young and old individuals, and particularly using Concanavalin A with respect to anti-CD3 and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	219-244	superoxide dismutase 1	Homo sapiens	53-56
8136303-2	1994	Treatment of MCF-7 cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (10(-7) M) was associated with a time-dependent increase in specific binding of [3H]dexamethasone (34.8 +/- 4.6 fmol/mg protein after 9 h of TPA treatment compared with 16.0 +/- 2.3 fmol/mg protein in control cells) as well as a transient induction in the level of glucocorticoid receptor (GR) mRNA (4- to 8-fold stimulation after 2-3 h, followed by a decline towards the control value after 6 h).	Tetradecanoylphorbol Acetate	48-84	nuclear receptor subfamily 3 group C member 1	Homo sapiens	356-379
8136303-2	1994	Treatment of MCF-7 cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (10(-7) M) was associated with a time-dependent increase in specific binding of [3H]dexamethasone (34.8 +/- 4.6 fmol/mg protein after 9 h of TPA treatment compared with 16.0 +/- 2.3 fmol/mg protein in control cells) as well as a transient induction in the level of glucocorticoid receptor (GR) mRNA (4- to 8-fold stimulation after 2-3 h, followed by a decline towards the control value after 6 h).	Tetradecanoylphorbol Acetate	48-84	nuclear receptor subfamily 3 group C member 1	Homo sapiens	381-383
8136303-2	1994	Treatment of MCF-7 cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (10(-7) M) was associated with a time-dependent increase in specific binding of [3H]dexamethasone (34.8 +/- 4.6 fmol/mg protein after 9 h of TPA treatment compared with 16.0 +/- 2.3 fmol/mg protein in control cells) as well as a transient induction in the level of glucocorticoid receptor (GR) mRNA (4- to 8-fold stimulation after 2-3 h, followed by a decline towards the control value after 6 h).	Tetradecanoylphorbol Acetate	86-89	nuclear receptor subfamily 3 group C member 1	Homo sapiens	356-379
8136303-2	1994	Treatment of MCF-7 cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (10(-7) M) was associated with a time-dependent increase in specific binding of [3H]dexamethasone (34.8 +/- 4.6 fmol/mg protein after 9 h of TPA treatment compared with 16.0 +/- 2.3 fmol/mg protein in control cells) as well as a transient induction in the level of glucocorticoid receptor (GR) mRNA (4- to 8-fold stimulation after 2-3 h, followed by a decline towards the control value after 6 h).	Tetradecanoylphorbol Acetate	86-89	nuclear receptor subfamily 3 group C member 1	Homo sapiens	381-383
8136303-3	1994	In the presence of the transcription inhibitor actinomycin D (AMD) (5.0 micrograms/ml) the TPA-dependent induction of GR mRNA was completely abolished, and GR mRNA showed a gradual decline with a half-life of 2-3 h. In contrast, treatment with TPA and the protein synthesis inhibitor cycloheximide (50 microM) resulted in a superinduction of GR mRNA (&gt; 50-fold after 6 h).	Tetradecanoylphorbol Acetate	91-94	nuclear receptor subfamily 3 group C member 1	Homo sapiens	118-120
8136303-5	1994	We conclude that the increase in GR mRNA in the presence of TPA is dependent on ongoing transcription, whereas the rate by which GR transcripts are degraded, is not altered by TPA.	Tetradecanoylphorbol Acetate	60-63	nuclear receptor subfamily 3 group C member 1	Homo sapiens	33-35
8127002-6	1994	The protein kinase (PKC)-activating phorbor ester, phorbor myristate acetate (PMA), stimulated endothelin-1 secretion and heparin inhibited PMA-stimulated endothelin-1 secretion.	Tetradecanoylphorbol Acetate	78-81	endothelin 1	Rattus norvegicus	95-107
8127002-6	1994	The protein kinase (PKC)-activating phorbor ester, phorbor myristate acetate (PMA), stimulated endothelin-1 secretion and heparin inhibited PMA-stimulated endothelin-1 secretion.	Tetradecanoylphorbol Acetate	78-81	endothelin 1	Rattus norvegicus	155-167
8035664-4	1994	PMNs stimulated with phorbol 12-myristate 13-acetate increased the oxidation rates of CYS and BSA, and they were inhibited by SOD and CAT almost in a similar way to those by HX-XO.	Tetradecanoylphorbol Acetate	21-52	superoxide dismutase 1	Homo sapiens	126-129
8035664-4	1994	PMNs stimulated with phorbol 12-myristate 13-acetate increased the oxidation rates of CYS and BSA, and they were inhibited by SOD and CAT almost in a similar way to those by HX-XO.	Tetradecanoylphorbol Acetate	21-52	catalase	Homo sapiens	134-137
8289471-7	1994	Upon stimulation with the phorbol ester TPA we detected a weak expression of Met/HGF receptor specific transcripts of 9.0 kb in peripheral blood mononuclear cells of a healthy donor.	Tetradecanoylphorbol Acetate	40-43	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	81-93
7904711-3	1994	Long-term 10(-7)M PMA treatment of cells neither affected membrane basal GC activity nor ANP-s-GC activity but partially inhibited ATP enhancement of ANP-s-GC.	Tetradecanoylphorbol Acetate	18-21	natriuretic peptide A	Homo sapiens	150-153
7904711-7	1994	The three- to four-fold ATP enhancement of cell membrane ANP-s-GC was not blocked by 12-hour preincubation of cells with 150 ng/mL PT but was completely blocked if 2-x-10(-7)M PMA was then added for 20 minutes, indicating that acute activation of PKC by PMA does not require a functional "G-type" protein.	Tetradecanoylphorbol Acetate	176-179	natriuretic peptide A	Homo sapiens	57-60
7921926-6	1994	One injection of macrophages cultured either in presence of LPS+TPA or of LPS+TPA+PGE2 resulted in marked slow-down of the tumor growth.	Tetradecanoylphorbol Acetate	78-81	toll-like receptor 4	Mus musculus	74-77
7512195-2	1994	Activation of PKC by 12-O-tetradecanoylphorbol-13-acetate in the CHO-PKC alpha cells inhibited by approximately 75% the: 1) insulin-stimulated increase in antiphosphotyrosine precipitable phosphatidylinositol 3-kinase activity in these cells; 2) insulin-stimulated increase in PI 3-kinase activity associated with insulin receptor substrate-1; and 3) tyrosine phosphorylation of the endogenous substrate, insulin receptor substrate-1.	Tetradecanoylphorbol Acetate	21-57	insulin	Cricetulus griseus	124-131
7512195-2	1994	Activation of PKC by 12-O-tetradecanoylphorbol-13-acetate in the CHO-PKC alpha cells inhibited by approximately 75% the: 1) insulin-stimulated increase in antiphosphotyrosine precipitable phosphatidylinositol 3-kinase activity in these cells; 2) insulin-stimulated increase in PI 3-kinase activity associated with insulin receptor substrate-1; and 3) tyrosine phosphorylation of the endogenous substrate, insulin receptor substrate-1.	Tetradecanoylphorbol Acetate	21-57	insulin	Cricetulus griseus	246-253
8186461-1	1994	Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2) are produced by stimulation with phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) in human T cell leukemia Jurkat cells.	Tetradecanoylphorbol Acetate	146-149	interleukin 2	Homo sapiens	62-75
7577367-6	1994	C/EBP isoforms inhibited the phorbol 12-myristate 13-acetate (PMA)-stimulated HIV-1 promoter activity in human glioblastoma U138MG and neuroblastoma SHSY5Y cells, but not in HeLa epithelial cells, and this inhibition required the NF-kappa B element.	Tetradecanoylphorbol Acetate	29-60	nuclear factor kappa B subunit 1	Homo sapiens	230-240
8186461-1	1994	Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2) are produced by stimulation with phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) in human T cell leukemia Jurkat cells.	Tetradecanoylphorbol Acetate	146-149	interleukin 2	Homo sapiens	77-81
8186461-6	1994	We also found that the active CN partially replaces calcium ionophore in synergy with PMA to induce expression of endogenous GM-CSF and IL-2.	Tetradecanoylphorbol Acetate	86-89	interleukin 2	Homo sapiens	136-140
7577367-6	1994	C/EBP isoforms inhibited the phorbol 12-myristate 13-acetate (PMA)-stimulated HIV-1 promoter activity in human glioblastoma U138MG and neuroblastoma SHSY5Y cells, but not in HeLa epithelial cells, and this inhibition required the NF-kappa B element.	Tetradecanoylphorbol Acetate	62-65	CCAAT enhancer binding protein alpha	Homo sapiens	0-5
7577367-6	1994	C/EBP isoforms inhibited the phorbol 12-myristate 13-acetate (PMA)-stimulated HIV-1 promoter activity in human glioblastoma U138MG and neuroblastoma SHSY5Y cells, but not in HeLa epithelial cells, and this inhibition required the NF-kappa B element.	Tetradecanoylphorbol Acetate	62-65	nuclear factor kappa B subunit 1	Homo sapiens	230-240
7949466-6	1994	Phorbol 12-myristate 13-acetate (PMA) increased the phosphorylation of P-glycoprotein 6-fold and selectively decreased the accumulation of vinblastine in resistant MCF-7/AdrR cells.	Tetradecanoylphorbol Acetate	0-31	ATP binding cassette subfamily B member 1	Homo sapiens	71-85
7949466-6	1994	Phorbol 12-myristate 13-acetate (PMA) increased the phosphorylation of P-glycoprotein 6-fold and selectively decreased the accumulation of vinblastine in resistant MCF-7/AdrR cells.	Tetradecanoylphorbol Acetate	33-36	ATP binding cassette subfamily B member 1	Homo sapiens	71-85
8262983-5	1993	Furthermore, normal and active Fyn stimulated transcription from the IL-2 gene promoter when transfected cells were stimulated by concanavalin A plus 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	150-186	interleukin 2	Homo sapiens	69-73
8127941-5	1994	The TPA treatment induced a 10-fold increase in membrane-associate PKC activity only.	Tetradecanoylphorbol Acetate	4-7	proline rich transmembrane protein 2	Homo sapiens	67-70
7535423-3	1994	Addition of 4 beta-phorbol 12-myristate 13-acetate reduced VIP- but not forskolin-stimulated cAMP response.	Tetradecanoylphorbol Acetate	12-50	vasoactive intestinal polypeptide	Mus musculus	59-62
8253712-5	1993	Platelet-derived growth factor, alpha-thrombin, hydrogen peroxide, phorbol 12-myristate 13-acetate, and ionomycin also induced 3CH134 but to levels lower than angiotensin II.	Tetradecanoylphorbol Acetate	67-98	angiotensinogen	Homo sapiens	159-173
7505022-1	1993	Three different agents, dithiothreitol (DTT), Mn2+, and phorbol ester (TPA), were found to induce HL-60 cell adhesion to fibronectin through distinct mechanisms.	Tetradecanoylphorbol Acetate	71-74	fibronectin 1	Homo sapiens	121-132
7505022-7	1993	TPA-treated HL-60 cells adhere and spread on fibronectin substrates, whereas DTT- and Mn(2+)-treated cells adhere but do not spread.	Tetradecanoylphorbol Acetate	0-3	fibronectin 1	Homo sapiens	45-56
8253712-7	1993	Treatment with both phorbol 12-myristate 13-acetate and ionomycin induced 3CH134 mRNA to levels seen with angiotensin II, indicating that Ca2+ mobilization and protein kinase C activation can act synergistically to induce 3CH134.	Tetradecanoylphorbol Acetate	20-51	angiotensinogen	Homo sapiens	106-120
8267589-6	1993	Activators of protein kinase C, phorbol myristate acetate (PMA) and 1-oleyl-2-acetyl-sn-glycerol (OAG), inhibited cytosolic Ca(2+)-increase completely when induced by IL-8 and by 68-82% in the case of fMLP.	Tetradecanoylphorbol Acetate	32-57	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
8258682-8	1993	They displayed potent cytolytic activity against NK-sensitive targets, and, when stimulated with PMA+ionomycin, secreted IL-3 and IFN-gamma, but not IL-2 or IL-4.	Tetradecanoylphorbol Acetate	97-100	interleukin 3	Mus musculus	121-125
8258682-8	1993	They displayed potent cytolytic activity against NK-sensitive targets, and, when stimulated with PMA+ionomycin, secreted IL-3 and IFN-gamma, but not IL-2 or IL-4.	Tetradecanoylphorbol Acetate	97-100	interferon gamma	Mus musculus	130-139
8267589-6	1993	Activators of protein kinase C, phorbol myristate acetate (PMA) and 1-oleyl-2-acetyl-sn-glycerol (OAG), inhibited cytosolic Ca(2+)-increase completely when induced by IL-8 and by 68-82% in the case of fMLP.	Tetradecanoylphorbol Acetate	32-57	formyl peptide receptor 1	Homo sapiens	201-205
8268245-2	1993	IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner.	Tetradecanoylphorbol Acetate	39-75	TIMP metallopeptidase inhibitor 1	Homo sapiens	182-188
8268245-2	1993	IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner.	Tetradecanoylphorbol Acetate	77-80	TIMP metallopeptidase inhibitor 1	Homo sapiens	182-188
8267589-6	1993	Activators of protein kinase C, phorbol myristate acetate (PMA) and 1-oleyl-2-acetyl-sn-glycerol (OAG), inhibited cytosolic Ca(2+)-increase completely when induced by IL-8 and by 68-82% in the case of fMLP.	Tetradecanoylphorbol Acetate	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	167-171
8267589-6	1993	Activators of protein kinase C, phorbol myristate acetate (PMA) and 1-oleyl-2-acetyl-sn-glycerol (OAG), inhibited cytosolic Ca(2+)-increase completely when induced by IL-8 and by 68-82% in the case of fMLP.	Tetradecanoylphorbol Acetate	59-62	formyl peptide receptor 1	Homo sapiens	201-205
8280080-6	1993	The expression of MMP-3 and MMP-1 was further enhanced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	58-89	matrix metallopeptidase 3	Homo sapiens	18-23
8280066-0	1993	Phorbol 12-myristate 13-acetate-stimulated phosphorylation of erythrocyte membrane skeletal proteins is blocked by calpain inhibitors: possible role of protein kinase M. Human erythrocytes contain cytosolic protein kinase C (PKC) which, when activated by phorbol 12-myristate 13-acetate (PMA), induces the phosphorylation of the membrane skeletal proteins band 4.1, band 4.9 and adducin.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	207-223
8280066-0	1993	Phorbol 12-myristate 13-acetate-stimulated phosphorylation of erythrocyte membrane skeletal proteins is blocked by calpain inhibitors: possible role of protein kinase M. Human erythrocytes contain cytosolic protein kinase C (PKC) which, when activated by phorbol 12-myristate 13-acetate (PMA), induces the phosphorylation of the membrane skeletal proteins band 4.1, band 4.9 and adducin.	Tetradecanoylphorbol Acetate	0-31	proline rich transmembrane protein 2	Homo sapiens	225-228
8280080-6	1993	The expression of MMP-3 and MMP-1 was further enhanced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	91-94	matrix metallopeptidase 3	Homo sapiens	18-23
8128456-1	1993	Human platelets secreted phospholipase A2 in a dose- and time-dependent manner when challenged with thrombin, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), or collagen.	Tetradecanoylphorbol Acetate	110-147	phospholipase A2 group IB	Homo sapiens	25-41
8280080-13	1993	On the other hand, forskolin suppressed the PMA-mediated induction of MMP-1 and MMP-3 in synovial fibroblasts, while it enhanced or did not affect this induction in various types of human endothelial cells.	Tetradecanoylphorbol Acetate	44-47	matrix metallopeptidase 3	Homo sapiens	80-85
8281932-2	1993	In these cells ERK1 activation is induced by two distinct stimuli, insulin and tumor-promoting agent (TPA).	Tetradecanoylphorbol Acetate	102-105	mitogen-activated protein kinase 3	Homo sapiens	15-19
8281932-3	1993	While insulin was found to be more potent than TPA for ERK1 activation, both stimuli produced the same transient activation pattern with a rapid peak (reached within 5 min) followed by a fast decrease within 20 min.	Tetradecanoylphorbol Acetate	47-50	mitogen-activated protein kinase 3	Homo sapiens	55-59
8281932-5	1993	Interestingly, this inhibitor was found to be regulated by insulin and TPA with a profile that is the mirror image of ERK1 activity.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase 3	Homo sapiens	118-122
8281932-9	1993	Interestingly, phosphatase 2A treatment of extracts from 5-min TPA-treated cells (where the ERK1 inhibitor was weak) was able to induce an increase in the ERK1 repressing activity.	Tetradecanoylphorbol Acetate	63-66	mitogen-activated protein kinase 3	Homo sapiens	92-96
8281932-9	1993	Interestingly, phosphatase 2A treatment of extracts from 5-min TPA-treated cells (where the ERK1 inhibitor was weak) was able to induce an increase in the ERK1 repressing activity.	Tetradecanoylphorbol Acetate	63-66	mitogen-activated protein kinase 3	Homo sapiens	155-159
8128456-1	1993	Human platelets secreted phospholipase A2 in a dose- and time-dependent manner when challenged with thrombin, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), or collagen.	Tetradecanoylphorbol Acetate	149-152	phospholipase A2 group IB	Homo sapiens	25-41
8128456-2	1993	Enzyme release was maximal at concentrations of 0.1 units/ml of thrombin, 100 nM TPA, or 2 micrograms/ml of collagen; and complete by 2 min in platelets treated with thrombin or TPA.	Tetradecanoylphorbol Acetate	81-84	coagulation factor II, thrombin	Homo sapiens	166-174
8257426-8	1993	That the phosphorylated p67 protein we identified in immunoprecipitation experiments was p67phox was confirmed by the observation that no phosphorylated band of 67 kDa was immunoprecipitated from the cytosol and membranes of PMA-stimulated neutrophils from a p67phox-deficient chronic granulomatous disease patient.	Tetradecanoylphorbol Acetate	225-228	CD33 molecule	Homo sapiens	24-27
8253535-6	1993	Addition of TIMP (tissue inhibitors of metalloproteinase)-I inhibited TPA-enhanced invasion of Matrigel by only up to 13%.	Tetradecanoylphorbol Acetate	70-73	TIMP metallopeptidase inhibitor 1	Homo sapiens	12-16
8253535-6	1993	Addition of TIMP (tissue inhibitors of metalloproteinase)-I inhibited TPA-enhanced invasion of Matrigel by only up to 13%.	Tetradecanoylphorbol Acetate	70-73	TIMP metallopeptidase inhibitor 1	Homo sapiens	18-56
8267044-6	1993	Interleukin-4 significantly enhanced the stimulatory actions of phorbol 12-myristate 13-acetate, ionomycin, and epidermal growth factor but not interleukin-1 beta on prostaglandin E2 production.	Tetradecanoylphorbol Acetate	64-95	interleukin 4	Homo sapiens	0-13
8165623-6	1993	In vitro studies in blood and seminal plasma showed that heparin stimulated complexation of uPA and tPA with PCI, suggesting that negatively charged glycosaminoglycans in blood vessels and in the reproductive system may regulate PCI reactions with uPA and tPA.	Tetradecanoylphorbol Acetate	100-103	plasminogen activator, urokinase	Homo sapiens	248-251
8165623-6	1993	In vitro studies in blood and seminal plasma showed that heparin stimulated complexation of uPA and tPA with PCI, suggesting that negatively charged glycosaminoglycans in blood vessels and in the reproductive system may regulate PCI reactions with uPA and tPA.	Tetradecanoylphorbol Acetate	256-259	plasminogen activator, urokinase	Homo sapiens	92-95
8269612-6	1993	Mutagenic activation of MeIQx by PMA stimulated cells could be reduced by inhibitors of active oxygen such as mannitol, benzoate, dimethyl sulphoxide, superoxide dismutase and catalase and by inhibition of myeloperoxidase activity.	Tetradecanoylphorbol Acetate	33-36	catalase	Rattus norvegicus	176-184
8162345-3	1993	NHEK PKC activity increased up to 10-fold within the 1st hour of exposure to tetradecanoyl phorbol acetate (TPA), and gradually returned to control values within 72 h. TPA-induced PKC activity was enhanced by pretreatment of cultures with protein and RNA synthesis inhibitors.	Tetradecanoylphorbol Acetate	77-106	proline rich transmembrane protein 2	Homo sapiens	5-8
8258145-6	1993	H47 mAb also enhanced PMA-induced interleukin-2 receptor (IL-2R) expression and IL-2 synthesis, but did not induce a change in intracellular free calcium ([Ca2+]i) of T cells.	Tetradecanoylphorbol Acetate	22-25	interleukin 2	Homo sapiens	58-62
8258149-6	1993	Furthermore, IgD-R are also upregulated by pharmacologically active compounds that increase intracellular cAMP and by PMA/DiOG plus ionomycin, but not by either PMA or ionomycin alone.	Tetradecanoylphorbol Acetate	118-121	immunoglobulin heavy constant delta	Mus musculus	13-16
7694866-10	1993	Treatment with tetradecanoyl phorbol acetate (TPA), a potent activator of protein kinase C (PKC), in combination with IL-7 induced a level of c-myc expression greater than that elicited by either factor alone, suggesting that TPA and IL-7 utilize cooperative signaling pathways to increase c-myc gene expression.	Tetradecanoylphorbol Acetate	15-44	interleukin 7	Homo sapiens	234-238
7694866-10	1993	Treatment with tetradecanoyl phorbol acetate (TPA), a potent activator of protein kinase C (PKC), in combination with IL-7 induced a level of c-myc expression greater than that elicited by either factor alone, suggesting that TPA and IL-7 utilize cooperative signaling pathways to increase c-myc gene expression.	Tetradecanoylphorbol Acetate	46-49	interleukin 7	Homo sapiens	234-238
7694866-10	1993	Treatment with tetradecanoyl phorbol acetate (TPA), a potent activator of protein kinase C (PKC), in combination with IL-7 induced a level of c-myc expression greater than that elicited by either factor alone, suggesting that TPA and IL-7 utilize cooperative signaling pathways to increase c-myc gene expression.	Tetradecanoylphorbol Acetate	226-229	interleukin 7	Homo sapiens	118-122
8258334-8	1993	The involvement of PKC was confirmed by the observations that phorbol 12-myristate 13-acetate (PMA), a direct activator of PKC, induced the expression of the monokine mRNA and that SEB evoked the activation of membrane-associated PKC.	Tetradecanoylphorbol Acetate	62-93	proline rich transmembrane protein 2	Homo sapiens	19-22
8258334-8	1993	The involvement of PKC was confirmed by the observations that phorbol 12-myristate 13-acetate (PMA), a direct activator of PKC, induced the expression of the monokine mRNA and that SEB evoked the activation of membrane-associated PKC.	Tetradecanoylphorbol Acetate	62-93	proline rich transmembrane protein 2	Homo sapiens	123-126
8258334-8	1993	The involvement of PKC was confirmed by the observations that phorbol 12-myristate 13-acetate (PMA), a direct activator of PKC, induced the expression of the monokine mRNA and that SEB evoked the activation of membrane-associated PKC.	Tetradecanoylphorbol Acetate	62-93	proline rich transmembrane protein 2	Homo sapiens	123-126
8258334-8	1993	The involvement of PKC was confirmed by the observations that phorbol 12-myristate 13-acetate (PMA), a direct activator of PKC, induced the expression of the monokine mRNA and that SEB evoked the activation of membrane-associated PKC.	Tetradecanoylphorbol Acetate	95-98	proline rich transmembrane protein 2	Homo sapiens	19-22
8258334-8	1993	The involvement of PKC was confirmed by the observations that phorbol 12-myristate 13-acetate (PMA), a direct activator of PKC, induced the expression of the monokine mRNA and that SEB evoked the activation of membrane-associated PKC.	Tetradecanoylphorbol Acetate	95-98	proline rich transmembrane protein 2	Homo sapiens	123-126
7925494-4	1993	We now report that gap junctions between C9 cells contain at least two junctional proteins, connexin26 (Cx26) and connexin43 (Cx43), and that the TPA-induced changes in IGJC correlate temporally to changes in the state of phosphorylation of Cx43.	Tetradecanoylphorbol Acetate	146-149	gap junction protein, alpha 1	Rattus norvegicus	114-124
7925494-4	1993	We now report that gap junctions between C9 cells contain at least two junctional proteins, connexin26 (Cx26) and connexin43 (Cx43), and that the TPA-induced changes in IGJC correlate temporally to changes in the state of phosphorylation of Cx43.	Tetradecanoylphorbol Acetate	146-149	gap junction protein, alpha 1	Rattus norvegicus	126-130
7925494-4	1993	We now report that gap junctions between C9 cells contain at least two junctional proteins, connexin26 (Cx26) and connexin43 (Cx43), and that the TPA-induced changes in IGJC correlate temporally to changes in the state of phosphorylation of Cx43.	Tetradecanoylphorbol Acetate	146-149	gap junction protein, alpha 1	Rattus norvegicus	241-245
7925494-5	1993	The latter changes were prevented by inhibition of protein kinase C. Phosphoamino acid analysis and two-dimensional tryptic peptide maps of 32P-labeled Cx43 showed that during the TPA-induced phosphorylation at least two of the phosphorylated forms of Cx43 were differentially phosphorylated in seryl residues as compared to control.	Tetradecanoylphorbol Acetate	180-183	gap junction protein, alpha 1	Rattus norvegicus	152-156
7925494-5	1993	The latter changes were prevented by inhibition of protein kinase C. Phosphoamino acid analysis and two-dimensional tryptic peptide maps of 32P-labeled Cx43 showed that during the TPA-induced phosphorylation at least two of the phosphorylated forms of Cx43 were differentially phosphorylated in seryl residues as compared to control.	Tetradecanoylphorbol Acetate	180-183	gap junction protein, alpha 1	Rattus norvegicus	252-256
8258334-8	1993	The involvement of PKC was confirmed by the observations that phorbol 12-myristate 13-acetate (PMA), a direct activator of PKC, induced the expression of the monokine mRNA and that SEB evoked the activation of membrane-associated PKC.	Tetradecanoylphorbol Acetate	95-98	proline rich transmembrane protein 2	Homo sapiens	123-126
8162345-3	1993	NHEK PKC activity increased up to 10-fold within the 1st hour of exposure to tetradecanoyl phorbol acetate (TPA), and gradually returned to control values within 72 h. TPA-induced PKC activity was enhanced by pretreatment of cultures with protein and RNA synthesis inhibitors.	Tetradecanoylphorbol Acetate	77-106	proline rich transmembrane protein 2	Homo sapiens	180-183
8162345-3	1993	NHEK PKC activity increased up to 10-fold within the 1st hour of exposure to tetradecanoyl phorbol acetate (TPA), and gradually returned to control values within 72 h. TPA-induced PKC activity was enhanced by pretreatment of cultures with protein and RNA synthesis inhibitors.	Tetradecanoylphorbol Acetate	108-111	proline rich transmembrane protein 2	Homo sapiens	5-8
8162345-3	1993	NHEK PKC activity increased up to 10-fold within the 1st hour of exposure to tetradecanoyl phorbol acetate (TPA), and gradually returned to control values within 72 h. TPA-induced PKC activity was enhanced by pretreatment of cultures with protein and RNA synthesis inhibitors.	Tetradecanoylphorbol Acetate	108-111	proline rich transmembrane protein 2	Homo sapiens	180-183
8162345-3	1993	NHEK PKC activity increased up to 10-fold within the 1st hour of exposure to tetradecanoyl phorbol acetate (TPA), and gradually returned to control values within 72 h. TPA-induced PKC activity was enhanced by pretreatment of cultures with protein and RNA synthesis inhibitors.	Tetradecanoylphorbol Acetate	168-171	proline rich transmembrane protein 2	Homo sapiens	5-8
8162345-3	1993	NHEK PKC activity increased up to 10-fold within the 1st hour of exposure to tetradecanoyl phorbol acetate (TPA), and gradually returned to control values within 72 h. TPA-induced PKC activity was enhanced by pretreatment of cultures with protein and RNA synthesis inhibitors.	Tetradecanoylphorbol Acetate	168-171	proline rich transmembrane protein 2	Homo sapiens	180-183
8253876-8	1993	These data demonstrate that TPA-stimulated lymphoid cells adhere to type IV collagen and subsequently synthesize and secrete gelatinase B and TIMP-1.	Tetradecanoylphorbol Acetate	28-31	TIMP metallopeptidase inhibitor 1	Homo sapiens	142-148
8300159-5	1993	However, pretreatment with the phorbol ester TPA, which directly activates protein kinase C (PKC), caused a marked increase in mediator release and InsP3 production in the CD45-deficient variant compared to the parental RBL-2H3 cells.	Tetradecanoylphorbol Acetate	45-48	RB transcriptional corepressor like 2	Rattus norvegicus	220-225
8680438-10	1993	We observed that 12-O-tetradecanoylphorbol 13-acetate (TPA) and forskolin increased the basal rate of SgII synthesis.	Tetradecanoylphorbol Acetate	17-53	secretogranin II	Bos taurus	102-106
8680438-10	1993	We observed that 12-O-tetradecanoylphorbol 13-acetate (TPA) and forskolin increased the basal rate of SgII synthesis.	Tetradecanoylphorbol Acetate	55-58	secretogranin II	Bos taurus	102-106
8680438-11	1993	Incubation with both TPA and forskolin was required to obtain an effect comparable to that produced by nicotine or histamine suggesting that these secretagogues recruit both protein kinase C- and cyclic AMP-dependent mechanisms to stimulate SgII synthesis.	Tetradecanoylphorbol Acetate	21-24	secretogranin II	Bos taurus	241-245
8255104-11	1993	Cells exposed to phorbol myristate acetate (PMA) had increased expression of CD11a, CD11b, CD18, CD45RO, and HLA-DR, whereas expression of CD15 and CD30 was markedly decreased.	Tetradecanoylphorbol Acetate	17-42	integrin subunit beta 2	Homo sapiens	91-95
7504152-0	1993	Sustained c-kit expression in a human erythroleukemia cell line (HEL) after megakaryocytic differentiation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	118-154	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	10-15
7504152-0	1993	Sustained c-kit expression in a human erythroleukemia cell line (HEL) after megakaryocytic differentiation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	156-159	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	10-15
7504152-1	1993	Changes in c-kit proto-oncogene expression were examined in a human erythroleukemia cell line, HEL, during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	145-148	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	11-16
7504152-2	1993	When HEL cells were treated with 10(-7) M TPA, glycophorin A expression and hemoglobin synthesis were reduced, while the expression of GP IIb/IIIa was induced in association with the morphological changes.	Tetradecanoylphorbol Acetate	42-45	glycophorin A (MNS blood group)	Homo sapiens	47-60
8246947-7	1993	In contrast, in Swiss 3T3 cells, inhibition of both p21ras activation and TPA-sensitive PKC, but not calcium influx, inhibited EGF-induced ERK2 phosphorylation.	Tetradecanoylphorbol Acetate	74-77	mitogen-activated protein kinase 1	Mus musculus	139-143
8145770-4	1993	We show that selective inhibition of protein kinase C (PKC) and its depletion by prolonged treatment with 12-O-tetradecanoylphorbol-13-acetate lead to the loss of ligand-dependent transcription of an RA-inducible promoter.	Tetradecanoylphorbol Acetate	106-142	protein kinase C alpha	Homo sapiens	55-58
7694875-2	1993	The cells were treated with the phosphodiesterase inhibitor isobutyl-methylxanthine and the tumor promoting phorbol ester, phorbol-12-myristate 13-acetate; activators of the cyclic AMP (cAMP) and protein kinase C (PKC) second messenger pathways, respectively.	Tetradecanoylphorbol Acetate	123-154	cathelicidin antimicrobial peptide	Homo sapiens	174-191
8264555-6	1993	UTP- and alpha-thrombin-induced changes in the levels of IPs, cytosolic Ca2+, and agonist-elicited cAMP accumulation were dramatically inhibited (&gt; 80%) by acute treatment of the cells with the protein kinase C activator 4 beta-phorbol 12-myristate 13-acetate but not with the inactive ester 4 alpha-phorbol 12,13-didecanoate.	Tetradecanoylphorbol Acetate	226-262	coagulation factor II	Mus musculus	15-23
8256116-8	1993	Similar data were obtained with cells transfected with a reporter plasmid containing the PMA-responsive element (containing a putative AP-1 binding site) of the IL-1 beta gene.	Tetradecanoylphorbol Acetate	89-92	interleukin 1 beta	Homo sapiens	161-170
8247003-1	1993	The human monocytic leukemia cell line THP-1 differentiates into macrophage-like cells when treated with a variety of agents, including 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	136-172	GLI family zinc finger 2	Homo sapiens	39-44
8247003-1	1993	The human monocytic leukemia cell line THP-1 differentiates into macrophage-like cells when treated with a variety of agents, including 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	174-177	GLI family zinc finger 2	Homo sapiens	39-44
7693343-6	1993	TGF-beta 2 RNA expression was found to be significantly down-modulated by 24 h of TPA treatment and remained low even at later times.	Tetradecanoylphorbol Acetate	82-85	transforming growth factor, beta 2	Mus musculus	0-10
8250925-2	1993	We report here that nitrite production by phorbol myristate acetate (PMA)-stimulated human polymorphonuclear leukocytes (PMN) is considerably increased by the addition of azide and a further increase occurs when catalase also is added.	Tetradecanoylphorbol Acetate	42-67	catalase	Homo sapiens	212-220
8250925-2	1993	We report here that nitrite production by phorbol myristate acetate (PMA)-stimulated human polymorphonuclear leukocytes (PMN) is considerably increased by the addition of azide and a further increase occurs when catalase also is added.	Tetradecanoylphorbol Acetate	69-72	catalase	Homo sapiens	212-220
7504467-2	1993	T lymphoblast adhesion to ECM proteins stimulated by ionomycin, thapsigargin, or PMA was inhibited by an anti-beta 1 integrin mAb (4B4), confirming the role of beta 1 integrins in regulated T cell-ECM interactions.	Tetradecanoylphorbol Acetate	81-84	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	110-116
8228252-0	1993	Mechanism of release of soluble forms of tumor necrosis factor/lymphotoxin receptors by phorbol myristate acetate-stimulated human THP-1 cells in vitro.	Tetradecanoylphorbol Acetate	88-113	GLI family zinc finger 2	Homo sapiens	131-136
8228256-5	1993	FPR-transfected HL60 cells retained their ability to undergo granulocytic differentiation with dibutyryl cAMP, as determined by FMLP- and PMA-stimulated superoxide production.	Tetradecanoylphorbol Acetate	138-141	formyl peptide receptor 1	Homo sapiens	0-3
8226971-6	1993	Phorbol 12-myristate 13-acetate, thrombin, or antigen caused no phosphorylation of ET-FR but stimulated exclusively fast form phosphorylation of ET-C5aR.	Tetradecanoylphorbol Acetate	0-31	complement C5a receptor 1	Rattus norvegicus	148-152
8226971-9	1993	Of note, ET-C5aR but not ET-FR underwent heterologous desensitization by antigen, phorbol 12-myristate 13-acetate, and thrombin.	Tetradecanoylphorbol Acetate	82-113	complement C5a receptor 1	Rattus norvegicus	12-16
8228252-6	1993	Colchicine at 1 and 10 microM stimulated the production of both soluble TNF/LT receptors, but the PMA-induced release of both soluble TNF/LT receptors was inhibited.	Tetradecanoylphorbol Acetate	98-101	tumor necrosis factor	Homo sapiens	134-137
8278627-7	1993	The study of the mechanism of action of this neuropeptide showed that protein kinase C (PKC) was activated in the presence of VIP concentrations from 10(-10) to 10(-8) M in a similar way to that found with a specific PKC activator such as phorbol myristate acetate (PMA, 50 ng/ml).	Tetradecanoylphorbol Acetate	239-264	vasoactive intestinal peptide	Rattus norvegicus	126-129
8278627-7	1993	The study of the mechanism of action of this neuropeptide showed that protein kinase C (PKC) was activated in the presence of VIP concentrations from 10(-10) to 10(-8) M in a similar way to that found with a specific PKC activator such as phorbol myristate acetate (PMA, 50 ng/ml).	Tetradecanoylphorbol Acetate	266-269	vasoactive intestinal peptide	Rattus norvegicus	126-129
8136266-2	1993	We found that interleukin 4 (IL-4), a T lymphocyte-derived cytokine known to regulate a number of monocyte functions, inhibited the production of TF by monocytes in response to endotoxin and phorbol myristate acetate (PMA) in vitro.	Tetradecanoylphorbol Acetate	191-216	interleukin 4	Homo sapiens	14-27
8217194-8	1993	Dexamethasone inhibited PMA-induced mRNA expression of PGHS-2 and PGD2 production.	Tetradecanoylphorbol Acetate	24-27	prostaglandin-endoperoxide synthase 2	Gallus gallus	55-61
8217193-5	1993	The superoxide production of AM stimulated by PMA was significantly inhibited by SP-A at a concentration of 1 microgram/ml (P &lt; 0.01), and superoxide production stimulated by zymosan was also inhibited by SP-A at a concentration of 10 micrograms/ml (P &lt; 0.05).	Tetradecanoylphorbol Acetate	46-49	surfactant protein A1	Rattus norvegicus	81-85
8217193-5	1993	The superoxide production of AM stimulated by PMA was significantly inhibited by SP-A at a concentration of 1 microgram/ml (P &lt; 0.01), and superoxide production stimulated by zymosan was also inhibited by SP-A at a concentration of 10 micrograms/ml (P &lt; 0.05).	Tetradecanoylphorbol Acetate	46-49	surfactant protein A1	Rattus norvegicus	208-212
7694572-1	1993	We have previously shown that vanadate potentiates the activating effect of phorbol ester (TPA) on cellular phospholipase A2 (PLA2) in a pathway dependent on the formation of reactive oxygen species (ROS).	Tetradecanoylphorbol Acetate	91-94	phospholipase A2 group IB	Homo sapiens	108-124
7694572-1	1993	We have previously shown that vanadate potentiates the activating effect of phorbol ester (TPA) on cellular phospholipase A2 (PLA2) in a pathway dependent on the formation of reactive oxygen species (ROS).	Tetradecanoylphorbol Acetate	91-94	phospholipase A2 group IB	Homo sapiens	126-130
7694572-7	1993	Collectively, the results show that ROS formation induced by TPA in association with vanadate is essential in the modulation of protein tyrosine phosphorylation and PLA2 activity.	Tetradecanoylphorbol Acetate	61-64	phospholipase A2 group IB	Homo sapiens	165-169
8136266-2	1993	We found that interleukin 4 (IL-4), a T lymphocyte-derived cytokine known to regulate a number of monocyte functions, inhibited the production of TF by monocytes in response to endotoxin and phorbol myristate acetate (PMA) in vitro.	Tetradecanoylphorbol Acetate	191-216	interleukin 4	Homo sapiens	29-33
8136266-2	1993	We found that interleukin 4 (IL-4), a T lymphocyte-derived cytokine known to regulate a number of monocyte functions, inhibited the production of TF by monocytes in response to endotoxin and phorbol myristate acetate (PMA) in vitro.	Tetradecanoylphorbol Acetate	218-221	interleukin 4	Homo sapiens	14-27
8136266-2	1993	We found that interleukin 4 (IL-4), a T lymphocyte-derived cytokine known to regulate a number of monocyte functions, inhibited the production of TF by monocytes in response to endotoxin and phorbol myristate acetate (PMA) in vitro.	Tetradecanoylphorbol Acetate	218-221	interleukin 4	Homo sapiens	29-33
8288312-1	1993	The distribution of protein kinase C (PKC) isoforms and phorbol 12-myristate 13-acetate (PMA)-induced activation of PKC in human monocytes was investigated.	Tetradecanoylphorbol Acetate	56-87	proline rich transmembrane protein 2	Homo sapiens	116-119
8242856-2	1993	Short-term treatment (15 min) with TPA, 1 microM, increased protein kinase C (PKC) activity in the particulate fraction of hepatocytes and, concomitantly, decreased the vasopressin (100 nM)-stimulated synthesis of inositol phosphates.	Tetradecanoylphorbol Acetate	35-38	arginine vasopressin	Rattus norvegicus	169-180
8223876-2	1993	The region extending from -317 to +47 relative to the initiation site of IL-2 gene transcription was shown to contain sequences able to respond to CD69 cross-linking, by enhancing by about 100% a phorbol 12-myristate 13-acetate (PMA)-plus-ionomycin stimulation of CAT activity.	Tetradecanoylphorbol Acetate	196-227	interleukin 2	Homo sapiens	73-77
8223876-2	1993	The region extending from -317 to +47 relative to the initiation site of IL-2 gene transcription was shown to contain sequences able to respond to CD69 cross-linking, by enhancing by about 100% a phorbol 12-myristate 13-acetate (PMA)-plus-ionomycin stimulation of CAT activity.	Tetradecanoylphorbol Acetate	229-232	interleukin 2	Homo sapiens	73-77
8404639-4	1993	In K562 cells, this selective junB mRNA induction was synergistically augmented by treatment with 12-O-tetradecanoyl phorbol-13-acetate but not affected by forskolin.	Tetradecanoylphorbol Acetate	98-135	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-34
8224186-6	1993	While PMA-induced growth arrest occurs in L-2 cells which possess PKC alpha and zeta, PMA-induced growth arrest does not occur in L-2/PMA which is deficient in these isoforms.	Tetradecanoylphorbol Acetate	6-9	protein kinase C alpha	Homo sapiens	66-75
8288312-1	1993	The distribution of protein kinase C (PKC) isoforms and phorbol 12-myristate 13-acetate (PMA)-induced activation of PKC in human monocytes was investigated.	Tetradecanoylphorbol Acetate	89-92	proline rich transmembrane protein 2	Homo sapiens	116-119
8288312-6	1993	Following the treatment of monocytes with PMA, the physical translocation of PKC alpha from the cytosol to the membrane occurred over 60 min.	Tetradecanoylphorbol Acetate	42-45	protein kinase C alpha	Homo sapiens	77-86
21573453-5	1993	Induction of proliferin by the tumour promoters butylated hydroxytoluene or TPA was efficiently inhibited at certain concentrations of catalase and superoxide dismutase, but retinoic acid had no effect.	Tetradecanoylphorbol Acetate	76-79	catalase	Mus musculus	135-143
8288312-8	1993	Fura-2 analysis demonstrated that PMA-induced PKC translocation was not accompanied by a net change in cytosolic calcium levels.	Tetradecanoylphorbol Acetate	34-37	proline rich transmembrane protein 2	Homo sapiens	46-49
8143891-1	1993	Intracellular effector systems which utilize PKA and PKC can be pharmacologically activated by forskolin and phorbol 12-myristate 13-acetate (PMA) and appear to be important for regulation of steroidogenesis by cells of the corpus luteum.	Tetradecanoylphorbol Acetate	109-140	proline rich transmembrane protein 2	Homo sapiens	53-56
8228802-5	1993	These IFN-gamma promoter constructs faithfully mirrored expression of the endogenous gene, in that expression required activation both with ionomycin and PMA, was inhibited by cyclosporin A, and was not observed in U937 or THP-1 cells.	Tetradecanoylphorbol Acetate	154-157	interferon gamma	Homo sapiens	6-15
8228332-10	1993	Calcipotriol decreased u-PA activity also in the presence of inducers of u-PA activity like transforming growth factor-beta, epidermal growth factor, and phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	154-185	plasminogen activator, urokinase	Homo sapiens	23-27
8264155-7	1993	Fetal calf serum and 12-o-tetradecanoyl- phorbol-13-acetate (TPA) transiently enhanced VPF/VEGF mRNA expression in cultured human MC.	Tetradecanoylphorbol Acetate	21-59	vascular endothelial growth factor A	Homo sapiens	87-90
8264155-7	1993	Fetal calf serum and 12-o-tetradecanoyl- phorbol-13-acetate (TPA) transiently enhanced VPF/VEGF mRNA expression in cultured human MC.	Tetradecanoylphorbol Acetate	21-59	vascular endothelial growth factor A	Homo sapiens	91-95
8264155-7	1993	Fetal calf serum and 12-o-tetradecanoyl- phorbol-13-acetate (TPA) transiently enhanced VPF/VEGF mRNA expression in cultured human MC.	Tetradecanoylphorbol Acetate	61-64	vascular endothelial growth factor A	Homo sapiens	87-90
8264155-7	1993	Fetal calf serum and 12-o-tetradecanoyl- phorbol-13-acetate (TPA) transiently enhanced VPF/VEGF mRNA expression in cultured human MC.	Tetradecanoylphorbol Acetate	61-64	vascular endothelial growth factor A	Homo sapiens	91-95
8264155-9	1993	Dexamethasone (DEX) inhibited the TPA-induced increase in VPF/VEGF mRNA expression, whereas DEX did not change the basal level.	Tetradecanoylphorbol Acetate	34-37	vascular endothelial growth factor A	Homo sapiens	58-61
8264155-9	1993	Dexamethasone (DEX) inhibited the TPA-induced increase in VPF/VEGF mRNA expression, whereas DEX did not change the basal level.	Tetradecanoylphorbol Acetate	34-37	vascular endothelial growth factor A	Homo sapiens	62-66
8264155-10	1993	The DEX depressed the TPA-induced increase in VPF/VEGF mRNA expression is therefore probably a result of transcriptional control.	Tetradecanoylphorbol Acetate	22-25	vascular endothelial growth factor A	Homo sapiens	46-49
8264155-10	1993	The DEX depressed the TPA-induced increase in VPF/VEGF mRNA expression is therefore probably a result of transcriptional control.	Tetradecanoylphorbol Acetate	22-25	vascular endothelial growth factor A	Homo sapiens	50-54
8264155-12	1993	TPA increased VPF/VEGF protein levels as well as those of VPF/VEGF mRNA in cultured human MC.	Tetradecanoylphorbol Acetate	0-3	vascular endothelial growth factor A	Homo sapiens	14-17
8264155-12	1993	TPA increased VPF/VEGF protein levels as well as those of VPF/VEGF mRNA in cultured human MC.	Tetradecanoylphorbol Acetate	0-3	vascular endothelial growth factor A	Homo sapiens	18-22
8228617-4	1993	On the other hand, a phorbol ester (phorbol myristate acetate, PMA) stimulated TNF-alpha release at 20 h of incubation but not at 7 h. Under nonstimulated culture conditions, 5-10% of all AMs released detectable TNF-alpha PMA (but not LPS) induced a significant increase in the fraction of AMs capable of releasing TNF-alpha (15.1 +/- 1.1% vs. 9.0 +/- 1.6%, PMA vs. control, P &lt; .05).	Tetradecanoylphorbol Acetate	36-61	tumor necrosis factor	Homo sapiens	79-88
8228617-4	1993	On the other hand, a phorbol ester (phorbol myristate acetate, PMA) stimulated TNF-alpha release at 20 h of incubation but not at 7 h. Under nonstimulated culture conditions, 5-10% of all AMs released detectable TNF-alpha PMA (but not LPS) induced a significant increase in the fraction of AMs capable of releasing TNF-alpha (15.1 +/- 1.1% vs. 9.0 +/- 1.6%, PMA vs. control, P &lt; .05).	Tetradecanoylphorbol Acetate	36-61	tumor necrosis factor	Homo sapiens	212-221
8228617-4	1993	On the other hand, a phorbol ester (phorbol myristate acetate, PMA) stimulated TNF-alpha release at 20 h of incubation but not at 7 h. Under nonstimulated culture conditions, 5-10% of all AMs released detectable TNF-alpha PMA (but not LPS) induced a significant increase in the fraction of AMs capable of releasing TNF-alpha (15.1 +/- 1.1% vs. 9.0 +/- 1.6%, PMA vs. control, P &lt; .05).	Tetradecanoylphorbol Acetate	36-61	tumor necrosis factor	Homo sapiens	212-221
8228617-4	1993	On the other hand, a phorbol ester (phorbol myristate acetate, PMA) stimulated TNF-alpha release at 20 h of incubation but not at 7 h. Under nonstimulated culture conditions, 5-10% of all AMs released detectable TNF-alpha PMA (but not LPS) induced a significant increase in the fraction of AMs capable of releasing TNF-alpha (15.1 +/- 1.1% vs. 9.0 +/- 1.6%, PMA vs. control, P &lt; .05).	Tetradecanoylphorbol Acetate	63-66	tumor necrosis factor	Homo sapiens	79-88
8228617-4	1993	On the other hand, a phorbol ester (phorbol myristate acetate, PMA) stimulated TNF-alpha release at 20 h of incubation but not at 7 h. Under nonstimulated culture conditions, 5-10% of all AMs released detectable TNF-alpha PMA (but not LPS) induced a significant increase in the fraction of AMs capable of releasing TNF-alpha (15.1 +/- 1.1% vs. 9.0 +/- 1.6%, PMA vs. control, P &lt; .05).	Tetradecanoylphorbol Acetate	63-66	tumor necrosis factor	Homo sapiens	212-221
8228617-4	1993	On the other hand, a phorbol ester (phorbol myristate acetate, PMA) stimulated TNF-alpha release at 20 h of incubation but not at 7 h. Under nonstimulated culture conditions, 5-10% of all AMs released detectable TNF-alpha PMA (but not LPS) induced a significant increase in the fraction of AMs capable of releasing TNF-alpha (15.1 +/- 1.1% vs. 9.0 +/- 1.6%, PMA vs. control, P &lt; .05).	Tetradecanoylphorbol Acetate	63-66	tumor necrosis factor	Homo sapiens	212-221
8246449-9	1993	Although GH mRNA transcript was markedly changed by dexamethasone and phorbol 12-myristate 13-acetate in vitro, Pit-1 mRNA transcripts were not changed significantly by these secretagogues.	Tetradecanoylphorbol Acetate	70-101	growth hormone 1	Homo sapiens	9-11
8143907-3	1993	This hypothesis has been tested by comparing the site and mode of action of PGF2 alpha, a PGF2 alpha analogue (cloprostenol) and the PKC activator phorbol myristate acetate (4 beta PMA) in human granulosa-lutein cells.	Tetradecanoylphorbol Acetate	147-172	proline rich transmembrane protein 2	Homo sapiens	133-136
8413264-2	1993	Treatment of the transfected cells with various combinations of the inducers lipopolysaccharide, phorbol myristate acetate, and dibutyryl cyclic AMP upregulated the IL-1 beta promoter.	Tetradecanoylphorbol Acetate	97-122	interleukin 1 beta	Homo sapiens	165-174
8143891-1	1993	Intracellular effector systems which utilize PKA and PKC can be pharmacologically activated by forskolin and phorbol 12-myristate 13-acetate (PMA) and appear to be important for regulation of steroidogenesis by cells of the corpus luteum.	Tetradecanoylphorbol Acetate	142-145	proline rich transmembrane protein 2	Homo sapiens	53-56
7691609-3	1993	In this study we observed that the surface expression of CD59 on the cultured EA.hy 926 endothelial cell line can be up-regulated to an approximately threefold higher level after a 72-h stimulation by the protein kinase C inducers phorbol-12-myristate-13 acetate (PMA; 10 nM) and calcium ionophore, A23187 (100 nM).	Tetradecanoylphorbol Acetate	231-262	CD59 molecule (CD59 blood group)	Homo sapiens	57-61
8290785-4	1993	The granulocytes showed a significant deficit in chemotaxis stimulated by serum activated with E. Coli, casein and formyl-methionyl-leucylphenylalanine (fMLP) (p &lt; 0.01) and in superoxide production stimulated by phorbol-myristate-acetate (PMA).	Tetradecanoylphorbol Acetate	216-241	formyl peptide receptor 1	Homo sapiens	153-157
8290785-4	1993	The granulocytes showed a significant deficit in chemotaxis stimulated by serum activated with E. Coli, casein and formyl-methionyl-leucylphenylalanine (fMLP) (p &lt; 0.01) and in superoxide production stimulated by phorbol-myristate-acetate (PMA).	Tetradecanoylphorbol Acetate	243-246	formyl peptide receptor 1	Homo sapiens	153-157
8402688-4	1993	Furthermore, stimulation of one of the N-type clones, SH-SY5Y, with the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, induced differentiation toward a more neuronal-like phenotype and resulted in a 5- to 10-fold elevation in the relative levels of Bcl-2 protein.	Tetradecanoylphorbol Acetate	87-123	BCL2 apoptosis regulator	Homo sapiens	255-260
8405436-1	1993	TPA induces translocation and down-regulation of conventional and new PKC isoforms but not atypical PKC zeta.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	70-73
8405436-4	1993	Exposure of the cells to 100 nM TPA for 10 min resulted in the translocation of conventional PKC alpha (cPKC alpha) and new PKC delta (nPKC delta) and -epsilon from the cytosolic to the membrane fraction, while left atypical PKC zeta (aPKC zeta) unaffected.	Tetradecanoylphorbol Acetate	32-35	protein kinase C alpha	Homo sapiens	93-102
8407934-6	1993	After activation of neutrophils with phorbol 12-myristate 13-acetate or formyl-methionyl-leucyl-phenylalanine, Rac was translocated from the cytosol to the plasma membrane, and this translocation corresponded temporally with the translocation of p47-phox and p67-phox and with the generation of superoxide.	Tetradecanoylphorbol Acetate	37-68	AKT serine/threonine kinase 1	Homo sapiens	111-114
8407934-6	1993	After activation of neutrophils with phorbol 12-myristate 13-acetate or formyl-methionyl-leucyl-phenylalanine, Rac was translocated from the cytosol to the plasma membrane, and this translocation corresponded temporally with the translocation of p47-phox and p67-phox and with the generation of superoxide.	Tetradecanoylphorbol Acetate	37-68	CD33 molecule	Homo sapiens	259-262
8238402-4	1993	In endothelial cells in which PKC had been desensitized to TPA by pretreatment for 24 h, addition of TNF caused overexpression of Mn-SOD.	Tetradecanoylphorbol Acetate	59-62	tumor necrosis factor	Homo sapiens	101-104
8398177-10	1993	TNF also significantly increased proteolysis when neutrophils were concurrently treated with phorbol myristate acetate or N-formylmethionylleucylphenylalanine.	Tetradecanoylphorbol Acetate	93-118	tumor necrosis factor	Homo sapiens	0-3
8104537-10	1993	On preactivating the same cells, using phorbol myristate acetate (PMA)/ionomycin on concanavalin A (ConA) or especially PHA, levels of CD26 were upregulated and the immunotoxin effectively inhibited the ability to provide help for B-cell Ig synthesis while leaving intact the CD4-CD26+ and CD4+CD26- populations; an effect observed both functionally and by phenotype.	Tetradecanoylphorbol Acetate	39-64	CD4 molecule	Homo sapiens	276-279
8287040-2	1993	12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophorin A) and myelocytic (CD11b) antigens in K562-L, but increased the expression of these antigens in K562-H. TPA increased the megakaryocytic (CD61) antigens in both cells.	Tetradecanoylphorbol Acetate	0-37	glycophorin A (MNS blood group)	Homo sapiens	91-104
8287040-2	1993	12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophorin A) and myelocytic (CD11b) antigens in K562-L, but increased the expression of these antigens in K562-H. TPA increased the megakaryocytic (CD61) antigens in both cells.	Tetradecanoylphorbol Acetate	0-37	integrin subunit beta 3	Homo sapiens	241-245
8287040-2	1993	12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophorin A) and myelocytic (CD11b) antigens in K562-L, but increased the expression of these antigens in K562-H. TPA increased the megakaryocytic (CD61) antigens in both cells.	Tetradecanoylphorbol Acetate	39-42	glycophorin A (MNS blood group)	Homo sapiens	91-104
8287040-2	1993	12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophorin A) and myelocytic (CD11b) antigens in K562-L, but increased the expression of these antigens in K562-H. TPA increased the megakaryocytic (CD61) antigens in both cells.	Tetradecanoylphorbol Acetate	39-42	integrin subunit beta 3	Homo sapiens	241-245
8168159-6	1993	Exposing cells to phorbol myristate acetate (PMA) or dibutyryl cyclic AMP (db cAMP) enhanced the secretion of scu-PA and two-chain u-PA, whereas 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7) decreased scu-PA secretion, indicating that it is enhanced by protein kinase C (PKC) as well as by cAMP in NY cells.	Tetradecanoylphorbol Acetate	18-43	plasminogen activator, urokinase	Homo sapiens	112-116
8168159-6	1993	Exposing cells to phorbol myristate acetate (PMA) or dibutyryl cyclic AMP (db cAMP) enhanced the secretion of scu-PA and two-chain u-PA, whereas 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7) decreased scu-PA secretion, indicating that it is enhanced by protein kinase C (PKC) as well as by cAMP in NY cells.	Tetradecanoylphorbol Acetate	45-48	plasminogen activator, urokinase	Homo sapiens	112-116
8104779-2	1993	The criterion for the functional state was NPY production in response to a 24-h exposure to forskolin + phorbol 12-myristate 13-acetate (For + PMA).	Tetradecanoylphorbol Acetate	104-135	neuropeptide Y	Rattus norvegicus	43-46
8162343-3	1993	When human PBMC and U937 cells were stimulated by phytohemagglutinin (PHA) and 12-0-tetradecanoyl-phorbol-13-acetate (TPA), respectively, the cells released significant amounts of TNF-alpha as determined by TNF-alpha-specific enzyme immunoassay.	Tetradecanoylphorbol Acetate	118-121	tumor necrosis factor	Homo sapiens	180-189
8162343-3	1993	When human PBMC and U937 cells were stimulated by phytohemagglutinin (PHA) and 12-0-tetradecanoyl-phorbol-13-acetate (TPA), respectively, the cells released significant amounts of TNF-alpha as determined by TNF-alpha-specific enzyme immunoassay.	Tetradecanoylphorbol Acetate	118-121	tumor necrosis factor	Homo sapiens	207-216
8162343-4	1993	TNF-alpha levels in the culture supernatant of PHA-stimulated human PBMC and TPA-activated U937 cells decreased in a dose-dependent manner when these cells were cultured in the presence of azelastine.	Tetradecanoylphorbol Acetate	77-80	tumor necrosis factor	Homo sapiens	0-9
8162343-6	1993	Moreover, azelastine also inhibited release of TNF-alpha from U937 cells which were already activated by TPA.	Tetradecanoylphorbol Acetate	105-108	tumor necrosis factor	Homo sapiens	47-56
8413306-1	1993	The interleukin-8 promoter is transcriptionally activated by interleukin-1, tumor necrosis factor alpha, phorbol myristate acetate, or hepatitis B virus X protein through a sequence located between positions -91 and -71.	Tetradecanoylphorbol Acetate	105-130	C-X-C motif chemokine ligand 8	Homo sapiens	4-17
8249125-6	1993	However, at therapeutic concentrations (0.1-5 micrograms/ml) vWF release by cells stimulated with thrombin, histamine, PMA, and the calcium ionophore A23187 was enhanced by both CsA and cremophor in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	119-122	von Willebrand factor	Homo sapiens	61-64
8400300-6	1993	When CD11b/CD18 expressing K562 cells were stimulated with phorbol myristate acetate (50 ng/mL) for 24 to 48 hours, these K562 cells formed dense cell:cell aggregates.	Tetradecanoylphorbol Acetate	59-84	integrin subunit beta 2	Homo sapiens	11-15
8216378-2	1993	In the present study we measured the inhibition by 34 compounds, either flavonoids or related substances, of the release of reactive oxygen species by human neutrophils after stimulation by three agents: the bacterial peptide N-fMetLeuPhe (FMLP), the protein kinase C activator phorbol myristate acetate (PMA) or opsonized zymosan (OZ), using two chemiluminescent probes, lucigenin or luminol in the presence or absence of horseradish peroxidase (HRP).	Tetradecanoylphorbol Acetate	278-303	formyl peptide receptor 1	Homo sapiens	240-244
8216378-2	1993	In the present study we measured the inhibition by 34 compounds, either flavonoids or related substances, of the release of reactive oxygen species by human neutrophils after stimulation by three agents: the bacterial peptide N-fMetLeuPhe (FMLP), the protein kinase C activator phorbol myristate acetate (PMA) or opsonized zymosan (OZ), using two chemiluminescent probes, lucigenin or luminol in the presence or absence of horseradish peroxidase (HRP).	Tetradecanoylphorbol Acetate	305-308	formyl peptide receptor 1	Homo sapiens	240-244
8238319-2	1993	Activation of PKC by phorbol 12-myristate 13-acetate (PMA) stimulated tyrosine phosphorylation and activation of p42MAPK to the same extent as AVP.	Tetradecanoylphorbol Acetate	21-52	mitogen-activated protein kinase 1	Homo sapiens	113-120
8238319-2	1993	Activation of PKC by phorbol 12-myristate 13-acetate (PMA) stimulated tyrosine phosphorylation and activation of p42MAPK to the same extent as AVP.	Tetradecanoylphorbol Acetate	54-57	mitogen-activated protein kinase 1	Homo sapiens	113-120
8238319-3	1993	Inhibition of PKC by staurosporine or downregulation of PKC by PMA pretreatment abolished AVP-induced stimulation of p42MAPK.	Tetradecanoylphorbol Acetate	63-66	arginine vasopressin	Homo sapiens	90-93
8238319-3	1993	Inhibition of PKC by staurosporine or downregulation of PKC by PMA pretreatment abolished AVP-induced stimulation of p42MAPK.	Tetradecanoylphorbol Acetate	63-66	mitogen-activated protein kinase 1	Homo sapiens	117-124
8104537-10	1993	On preactivating the same cells, using phorbol myristate acetate (PMA)/ionomycin on concanavalin A (ConA) or especially PHA, levels of CD26 were upregulated and the immunotoxin effectively inhibited the ability to provide help for B-cell Ig synthesis while leaving intact the CD4-CD26+ and CD4+CD26- populations; an effect observed both functionally and by phenotype.	Tetradecanoylphorbol Acetate	39-64	CD4 molecule	Homo sapiens	290-293
8104537-10	1993	On preactivating the same cells, using phorbol myristate acetate (PMA)/ionomycin on concanavalin A (ConA) or especially PHA, levels of CD26 were upregulated and the immunotoxin effectively inhibited the ability to provide help for B-cell Ig synthesis while leaving intact the CD4-CD26+ and CD4+CD26- populations; an effect observed both functionally and by phenotype.	Tetradecanoylphorbol Acetate	66-69	CD4 molecule	Homo sapiens	276-279
8104537-10	1993	On preactivating the same cells, using phorbol myristate acetate (PMA)/ionomycin on concanavalin A (ConA) or especially PHA, levels of CD26 were upregulated and the immunotoxin effectively inhibited the ability to provide help for B-cell Ig synthesis while leaving intact the CD4-CD26+ and CD4+CD26- populations; an effect observed both functionally and by phenotype.	Tetradecanoylphorbol Acetate	66-69	CD4 molecule	Homo sapiens	290-293
8274878-3	1993	Dexamethasone treatment increased the basal, PMA-, PTH-, (PTH + PMA)- and (forskolin + PMA)-sensitive adenylate cyclase while 1,25(OH)2D3 decreased these effects.	Tetradecanoylphorbol Acetate	64-67	parathyroid hormone	Rattus norvegicus	58-61
7691609-3	1993	In this study we observed that the surface expression of CD59 on the cultured EA.hy 926 endothelial cell line can be up-regulated to an approximately threefold higher level after a 72-h stimulation by the protein kinase C inducers phorbol-12-myristate-13 acetate (PMA; 10 nM) and calcium ionophore, A23187 (100 nM).	Tetradecanoylphorbol Acetate	264-267	CD59 molecule (CD59 blood group)	Homo sapiens	57-61
8223588-6	1993	The down-regulation of PKC by long-term treatment with phorbol 12-myristate 13-acetate eliminated zymosan-stimulated arachidonic acid release and eicosanoid synthesis (after 4-6 h treatment).	Tetradecanoylphorbol Acetate	55-86	protein kinase C, alpha	Mus musculus	23-26
8223588-9	1993	After exposure to phorbol 12-myristate 13-acetate, a complete depletion of PKC-beta was observed within 1 h and the complete depletion of PKC-alpha and PKC-delta isotypes was observed within 4 h. In contrast, PKC-epsilon was only partially down-regulated after a 24-h treatment with phorbol 12-myristate 13-acetate and PKC-zeta was not affected at all.	Tetradecanoylphorbol Acetate	18-49	protein kinase C, alpha	Mus musculus	138-147
8223588-9	1993	After exposure to phorbol 12-myristate 13-acetate, a complete depletion of PKC-beta was observed within 1 h and the complete depletion of PKC-alpha and PKC-delta isotypes was observed within 4 h. In contrast, PKC-epsilon was only partially down-regulated after a 24-h treatment with phorbol 12-myristate 13-acetate and PKC-zeta was not affected at all.	Tetradecanoylphorbol Acetate	283-314	protein kinase C, alpha	Mus musculus	138-147
8294141-4	1993	In addition PBMC incubated with LPGAP released interleukin-4 (IL-4) after pulsing with ionomycin and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	101-126	interleukin 4	Homo sapiens	47-60
7903276-4	1993	In the presence of phorbol myristate acetate (PMA), large amounts of IL-2 were induced by both anti-CD3 and anti-CD2 stimulation, which was accompanied by strong concurrent tyrosine phosphorylation of the 42,000 MW ERK and a 100,000 MW protein.	Tetradecanoylphorbol Acetate	19-44	interleukin 2	Homo sapiens	69-73
7903276-4	1993	In the presence of phorbol myristate acetate (PMA), large amounts of IL-2 were induced by both anti-CD3 and anti-CD2 stimulation, which was accompanied by strong concurrent tyrosine phosphorylation of the 42,000 MW ERK and a 100,000 MW protein.	Tetradecanoylphorbol Acetate	19-44	mitogen-activated protein kinase 1	Homo sapiens	215-218
7903276-4	1993	In the presence of phorbol myristate acetate (PMA), large amounts of IL-2 were induced by both anti-CD3 and anti-CD2 stimulation, which was accompanied by strong concurrent tyrosine phosphorylation of the 42,000 MW ERK and a 100,000 MW protein.	Tetradecanoylphorbol Acetate	46-49	interleukin 2	Homo sapiens	69-73
7903276-4	1993	In the presence of phorbol myristate acetate (PMA), large amounts of IL-2 were induced by both anti-CD3 and anti-CD2 stimulation, which was accompanied by strong concurrent tyrosine phosphorylation of the 42,000 MW ERK and a 100,000 MW protein.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 1	Homo sapiens	215-218
8262552-6	1993	TPA-activated U937 cells showed a two-fold increase in the expression of the RGD-dependent integrin receptors alpha 3 and alpha 5, and a reduction in the expression of alpha 4, another fibronectin-specific receptor, whereas the common beta 1 chain was unchanged.	Tetradecanoylphorbol Acetate	0-3	fibronectin 1	Homo sapiens	185-196
7691832-5	1993	Tetradecanoyl phorbol-13-acetate (TPA), forskolin, platelet-derived growth factor, fibroblast growth factor, and serum all induce mac-NOS expression in Swiss 3T3 cells.	Tetradecanoylphorbol Acetate	34-37	nitric oxide synthase 2, inducible	Mus musculus	130-137
7904268-5	1993	High concentrations (10(-7) to 10(-5) M) of phorbol myristate acetate but not of chemotactic peptide induced down-regulation of surface CD18.	Tetradecanoylphorbol Acetate	44-69	integrin subunit beta 2	Homo sapiens	136-140
8406825-5	1993	PMA completely restored IL-6 production and partially that of CSF.	Tetradecanoylphorbol Acetate	0-3	interleukin 6	Mus musculus	24-28
7691832-8	1993	TPA-induced mac-NOS and TIS10/PGS-2 mRNA accumulation patterns are similar.	Tetradecanoylphorbol Acetate	0-3	nitric oxide synthase 2, inducible	Mus musculus	12-19
8376930-1	1993	The phorbol ester phorbol myristate acetate (PMA) induces a rapid downregulation of CD4 from the surface of T cells and lymphocytic cell lines, as well as from CD4-transfected nonlymphoid cells.	Tetradecanoylphorbol Acetate	18-43	CD4 molecule	Homo sapiens	84-87
8408228-4	1993	Different from the stimulations with ATP and TPA, the effect of bradykinin of decreasing the high-affinity EGF binding was transient (a minimum binding at 2.5 min); the reduced EGF binding was, however, sustained for up to 30 min in the presence of calyculin A, a phosphoprotein phosphatase inhibitor.	Tetradecanoylphorbol Acetate	45-48	kininogen 1	Homo sapiens	64-74
8282758-3	1993	This effect of TPA required a persistent activation of PK-C and was accompanied by a slight decrease (30%) in the growth rate.	Tetradecanoylphorbol Acetate	15-18	proline rich transmembrane protein 2	Homo sapiens	55-59
8376930-1	1993	The phorbol ester phorbol myristate acetate (PMA) induces a rapid downregulation of CD4 from the surface of T cells and lymphocytic cell lines, as well as from CD4-transfected nonlymphoid cells.	Tetradecanoylphorbol Acetate	18-43	CD4 molecule	Homo sapiens	160-163
8376930-1	1993	The phorbol ester phorbol myristate acetate (PMA) induces a rapid downregulation of CD4 from the surface of T cells and lymphocytic cell lines, as well as from CD4-transfected nonlymphoid cells.	Tetradecanoylphorbol Acetate	45-48	CD4 molecule	Homo sapiens	84-87
8376930-1	1993	The phorbol ester phorbol myristate acetate (PMA) induces a rapid downregulation of CD4 from the surface of T cells and lymphocytic cell lines, as well as from CD4-transfected nonlymphoid cells.	Tetradecanoylphorbol Acetate	45-48	CD4 molecule	Homo sapiens	160-163
8376930-3	1993	Using HeLa-CD4 or NIH-3T3-CD4 cells, in which the endocytosis of CD4 is not influenced by the protein tyrosine kinase p56lck, we show that PMA enhanced the uptake of CD4, increasing the rate of CD4 endocytosis three to five-fold, and doubling the proportion of CD4 found inside the cells.	Tetradecanoylphorbol Acetate	139-142	CD4 molecule	Homo sapiens	11-14
8376930-3	1993	Using HeLa-CD4 or NIH-3T3-CD4 cells, in which the endocytosis of CD4 is not influenced by the protein tyrosine kinase p56lck, we show that PMA enhanced the uptake of CD4, increasing the rate of CD4 endocytosis three to five-fold, and doubling the proportion of CD4 found inside the cells.	Tetradecanoylphorbol Acetate	139-142	CD4 molecule	Homo sapiens	26-29
8376930-3	1993	Using HeLa-CD4 or NIH-3T3-CD4 cells, in which the endocytosis of CD4 is not influenced by the protein tyrosine kinase p56lck, we show that PMA enhanced the uptake of CD4, increasing the rate of CD4 endocytosis three to five-fold, and doubling the proportion of CD4 found inside the cells.	Tetradecanoylphorbol Acetate	139-142	CD4 molecule	Homo sapiens	26-29
8376930-3	1993	Using HeLa-CD4 or NIH-3T3-CD4 cells, in which the endocytosis of CD4 is not influenced by the protein tyrosine kinase p56lck, we show that PMA enhanced the uptake of CD4, increasing the rate of CD4 endocytosis three to five-fold, and doubling the proportion of CD4 found inside the cells.	Tetradecanoylphorbol Acetate	139-142	CD4 molecule	Homo sapiens	26-29
8376930-3	1993	Using HeLa-CD4 or NIH-3T3-CD4 cells, in which the endocytosis of CD4 is not influenced by the protein tyrosine kinase p56lck, we show that PMA enhanced the uptake of CD4, increasing the rate of CD4 endocytosis three to five-fold, and doubling the proportion of CD4 found inside the cells.	Tetradecanoylphorbol Acetate	139-142	CD4 molecule	Homo sapiens	26-29
8376930-3	1993	Using HeLa-CD4 or NIH-3T3-CD4 cells, in which the endocytosis of CD4 is not influenced by the protein tyrosine kinase p56lck, we show that PMA enhanced the uptake of CD4, increasing the rate of CD4 endocytosis three to five-fold, and doubling the proportion of CD4 found inside the cells.	Tetradecanoylphorbol Acetate	139-142	CD4 molecule	Homo sapiens	26-29
8376930-5	1993	Studies in which clathrin-coated pits were disrupted through the use of hypertonic media indicated that both the constitutive and PMA-induced CD4 uptake occurred through coated vesicles.	Tetradecanoylphorbol Acetate	130-133	CD4 molecule	Homo sapiens	142-145
8376930-8	1993	In lymphoid or p56lck-expressing transfected cells, these effects were preceded by the PMA-induced dissociation of CD4 and p56lck, which released CD4 and made possible increased endocytosis and altered intracellular trafficking.	Tetradecanoylphorbol Acetate	87-90	CD4 molecule	Homo sapiens	115-118
8376930-8	1993	In lymphoid or p56lck-expressing transfected cells, these effects were preceded by the PMA-induced dissociation of CD4 and p56lck, which released CD4 and made possible increased endocytosis and altered intracellular trafficking.	Tetradecanoylphorbol Acetate	87-90	CD4 molecule	Homo sapiens	146-149
8264660-12	1993	To test whether a transcriptional mechanism was involved in the stimulation of BNP mRNA by PMA, cells were treated with the inhibitor actinomycin D (5 micrograms/ml) for 24 h in the presence of PMA.	Tetradecanoylphorbol Acetate	91-94	natriuretic peptide B	Rattus norvegicus	79-82
8264660-3	1993	Addition of 10(-7) M phorbol 12-myristate 13-acetate (PMA) resulted in a 3- to 4-fold increase in immunoreactive BNP (irBNP) secretion 24-48 h after treatment.	Tetradecanoylphorbol Acetate	21-52	natriuretic peptide B	Rattus norvegicus	113-116
8264661-9	1993	Moreover, the DNA binding activity of TTF-2 is inhibited by both A23187 and TPA.	Tetradecanoylphorbol Acetate	76-79	transcription termination factor 2	Rattus norvegicus	38-43
8264660-3	1993	Addition of 10(-7) M phorbol 12-myristate 13-acetate (PMA) resulted in a 3- to 4-fold increase in immunoreactive BNP (irBNP) secretion 24-48 h after treatment.	Tetradecanoylphorbol Acetate	54-57	natriuretic peptide B	Rattus norvegicus	113-116
8264661-10	1993	Heterologous promoter constructs containing four, eight, or 12 tandem repeats of an oligonucleotide that includes the TTF-2 binding site increase their activity in response to TSH, forskolin, and insulin, while the the presence of A23187 or TPA inhibits their activity.	Tetradecanoylphorbol Acetate	241-244	transcription termination factor 2	Rattus norvegicus	118-123
8413215-4	1993	A nuclear complex was induced in phorbol myristate acetate-treated Jurkat T cells which bound specifically to the kappa B site of the IL-8 promoter and was inhibited by addition of purified I kappa B alpha to the reaction mixture.	Tetradecanoylphorbol Acetate	33-58	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
8413215-4	1993	A nuclear complex was induced in phorbol myristate acetate-treated Jurkat T cells which bound specifically to the kappa B site of the IL-8 promoter and was inhibited by addition of purified I kappa B alpha to the reaction mixture.	Tetradecanoylphorbol Acetate	33-58	NFKB inhibitor alpha	Homo sapiens	190-205
8413215-10	1993	Antisense oligonucleotides to RelA, but not NFKB1, inhibited phorbol myristate acetate-induced IL-8 production in Jurkat T lymphocytes.	Tetradecanoylphorbol Acetate	61-86	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
8264664-4	1993	When the TGF beta 1 promoter activity is induced by 12-O-tetradecanoyl phorbol13-acetate (an activator of AP-1-controlled gene transcription), this activity can be strongly repressed by retinoic acid receptor-alpha (RAR alpha), RAR beta, or retinoid X receptor-alpha (RXR alpha) as well as other members of the nuclear receptor family.	Tetradecanoylphorbol Acetate	52-88	transforming growth factor beta 1	Homo sapiens	9-19
8413223-2	1993	Probes representing the -300 region or the NF-kappa B site alone interacted with NF-kappa B proteins present in phorbol myristate acetate-, lipopolysaccharide-, or Sendai virus-induced myeloid cell extracts as well as recombinant NFKB1 (p50) and RelA (p65); furthermore, NF-kappa B protein-DNA complex formation was dissociated in vitro by the addition of recombinant I kappa B alpha.	Tetradecanoylphorbol Acetate	112-137	nuclear factor kappa B subunit 1	Homo sapiens	43-53
8264664-4	1993	When the TGF beta 1 promoter activity is induced by 12-O-tetradecanoyl phorbol13-acetate (an activator of AP-1-controlled gene transcription), this activity can be strongly repressed by retinoic acid receptor-alpha (RAR alpha), RAR beta, or retinoid X receptor-alpha (RXR alpha) as well as other members of the nuclear receptor family.	Tetradecanoylphorbol Acetate	52-88	retinoic acid receptor beta	Homo sapiens	228-236
8413223-2	1993	Probes representing the -300 region or the NF-kappa B site alone interacted with NF-kappa B proteins present in phorbol myristate acetate-, lipopolysaccharide-, or Sendai virus-induced myeloid cell extracts as well as recombinant NFKB1 (p50) and RelA (p65); furthermore, NF-kappa B protein-DNA complex formation was dissociated in vitro by the addition of recombinant I kappa B alpha.	Tetradecanoylphorbol Acetate	112-137	nuclear factor kappa B subunit 1	Homo sapiens	81-91
8413223-2	1993	Probes representing the -300 region or the NF-kappa B site alone interacted with NF-kappa B proteins present in phorbol myristate acetate-, lipopolysaccharide-, or Sendai virus-induced myeloid cell extracts as well as recombinant NFKB1 (p50) and RelA (p65); furthermore, NF-kappa B protein-DNA complex formation was dissociated in vitro by the addition of recombinant I kappa B alpha.	Tetradecanoylphorbol Acetate	112-137	nuclear factor kappa B subunit 1	Homo sapiens	230-235
8413223-2	1993	Probes representing the -300 region or the NF-kappa B site alone interacted with NF-kappa B proteins present in phorbol myristate acetate-, lipopolysaccharide-, or Sendai virus-induced myeloid cell extracts as well as recombinant NFKB1 (p50) and RelA (p65); furthermore, NF-kappa B protein-DNA complex formation was dissociated in vitro by the addition of recombinant I kappa B alpha.	Tetradecanoylphorbol Acetate	112-137	nuclear factor kappa B subunit 1	Homo sapiens	237-240
8105473-3	1993	Unglycosylated mdr1 retains the ability to bind the photoactivatable drug analog [125I]iodoarylazidoprazosin and confers resistance to tetraphenylphosphonium (TPP+) and tetraphenylarsonium (TPA+), known mdr1 substrates.	Tetradecanoylphorbol Acetate	190-193	ATP binding cassette subfamily B member 1	Homo sapiens	15-19
8413223-2	1993	Probes representing the -300 region or the NF-kappa B site alone interacted with NF-kappa B proteins present in phorbol myristate acetate-, lipopolysaccharide-, or Sendai virus-induced myeloid cell extracts as well as recombinant NFKB1 (p50) and RelA (p65); furthermore, NF-kappa B protein-DNA complex formation was dissociated in vitro by the addition of recombinant I kappa B alpha.	Tetradecanoylphorbol Acetate	112-137	nuclear factor kappa B subunit 1	Homo sapiens	81-91
8415663-3	1993	Although both exchangers were stimulated by serum, NHE3 was inhibited by phorbol 12-myristate 13-acetate (PMA), which stimulated NHE1.	Tetradecanoylphorbol Acetate	73-104	solute carrier family 9 member A1	Homo sapiens	129-133
8415663-3	1993	Although both exchangers were stimulated by serum, NHE3 was inhibited by phorbol 12-myristate 13-acetate (PMA), which stimulated NHE1.	Tetradecanoylphorbol Acetate	106-109	solute carrier family 9 member A1	Homo sapiens	129-133
8378087-2	1993	The chimaeric Fos-ER proteins showed estrogen-inducible activation of TRE (TPA-responsive element)-directed transcription and hormone-dependent transformation of fibroblasts.	Tetradecanoylphorbol Acetate	75-78	estrogen receptor 1	Homo sapiens	18-20
8397368-5	1993	In MHE226-CNR cells c-fos mRNA was induced by 12-O-tetradecanoyl phorbol 13-acetate (TPA) and bFGF, both inhibitors of MHE226-infected cell growth.	Tetradecanoylphorbol Acetate	46-83	Fos proto-oncogene, AP-1 transcription factor subunit	Gallus gallus	22-25
8397368-5	1993	In MHE226-CNR cells c-fos mRNA was induced by 12-O-tetradecanoyl phorbol 13-acetate (TPA) and bFGF, both inhibitors of MHE226-infected cell growth.	Tetradecanoylphorbol Acetate	85-88	Fos proto-oncogene, AP-1 transcription factor subunit	Gallus gallus	22-25
8396805-10	1993	The response to the phorbol ester TPA also required a cooperation of M33 and AP1.	Tetradecanoylphorbol Acetate	34-37	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-80
8257866-5	1993	The amount of immunoreactive (ir)-ET-1 secreted from the cells was also increased by TPA and was decreased by TSH.	Tetradecanoylphorbol Acetate	85-88	endothelin 1	Homo sapiens	34-38
8260934-6	1993	The 300-kD form of DNA-PK was only detected in TPA-treated nuclear extracts, raising the possibility that cell differentiation is associated with the down-regulation and/or the inhibition of a protease(s) capable of regulating DNA-PK turnover.	Tetradecanoylphorbol Acetate	47-50	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	19-25
8239270-1	1993	Release of the amyloid precursor protein (APP) of Alzheimer"s disease from Swiss 3T3 fibroblasts was stimulated in a concentration-dependent manner by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	151-182	amyloid beta precursor protein	Homo sapiens	15-40
8239270-3	1993	The effect of PMA was inhibited by the PKC antagonist H-7 in control cells, but not in cells that overexpressed PKC alpha.	Tetradecanoylphorbol Acetate	14-17	protein kinase C alpha	Homo sapiens	39-42
8373383-0	1993	Increment of the cyclin D1 mRNA level in TPA-treated three human myeloid leukemia cell lines: HEL, CMK and HL-60 cells.	Tetradecanoylphorbol Acetate	41-44	C-X-C motif chemokine ligand 9	Homo sapiens	99-102
8373383-3	1993	The similar marked increment of the cyclin D1 mRNA level was observed in other leukemia cell lines, CMK and HL-60 cells, after incubation with TPA.	Tetradecanoylphorbol Acetate	143-146	C-X-C motif chemokine ligand 9	Homo sapiens	100-103
7689566-5	1993	266, 10319-10323), we found that treatment with the phorbol ester, phorbol myristate acetate (PMA), reduced CFTR mRNA levels by approximately 80% with a t 1/2 of approximately 2 h. Chloride secretion, measured as forskolin-induced short circuit current, was also abolished by PMA with a t 1/2 of approximately 2 h. Levels of mature glycosylated CFTR measured by Western blotting also declined to 50 +/- 8% (n = 7) of control after a 12-h PMA treatment.	Tetradecanoylphorbol Acetate	67-92	CF transmembrane conductance regulator	Homo sapiens	108-112
7689566-5	1993	266, 10319-10323), we found that treatment with the phorbol ester, phorbol myristate acetate (PMA), reduced CFTR mRNA levels by approximately 80% with a t 1/2 of approximately 2 h. Chloride secretion, measured as forskolin-induced short circuit current, was also abolished by PMA with a t 1/2 of approximately 2 h. Levels of mature glycosylated CFTR measured by Western blotting also declined to 50 +/- 8% (n = 7) of control after a 12-h PMA treatment.	Tetradecanoylphorbol Acetate	67-92	CF transmembrane conductance regulator	Homo sapiens	345-349
7689566-5	1993	266, 10319-10323), we found that treatment with the phorbol ester, phorbol myristate acetate (PMA), reduced CFTR mRNA levels by approximately 80% with a t 1/2 of approximately 2 h. Chloride secretion, measured as forskolin-induced short circuit current, was also abolished by PMA with a t 1/2 of approximately 2 h. Levels of mature glycosylated CFTR measured by Western blotting also declined to 50 +/- 8% (n = 7) of control after a 12-h PMA treatment.	Tetradecanoylphorbol Acetate	94-97	CF transmembrane conductance regulator	Homo sapiens	108-112
7689566-5	1993	266, 10319-10323), we found that treatment with the phorbol ester, phorbol myristate acetate (PMA), reduced CFTR mRNA levels by approximately 80% with a t 1/2 of approximately 2 h. Chloride secretion, measured as forskolin-induced short circuit current, was also abolished by PMA with a t 1/2 of approximately 2 h. Levels of mature glycosylated CFTR measured by Western blotting also declined to 50 +/- 8% (n = 7) of control after a 12-h PMA treatment.	Tetradecanoylphorbol Acetate	94-97	CF transmembrane conductance regulator	Homo sapiens	345-349
7690250-2	1993	In the present study, inhibition of protein kinase C with calphostin C or stauroporine or prolonged treatment with the phorbol ester TPA decreased phosphorylation of P-glycoprotein, and impaired transport of vinblastine.	Tetradecanoylphorbol Acetate	133-136	ATP binding cassette subfamily B member 1	Homo sapiens	166-180
8396935-0	1993	Interleukin-1 and phorbol myristate acetate modulate the peripheral-type benzodiazepine receptor in lymphocytes and glial cells.	Tetradecanoylphorbol Acetate	18-43	translocator protein	Mus musculus	57-96
8376369-4	1993	However, the cell lines that overexpressed PKC-alpha or -delta had acquired the ability to become mature macrophages 2-6 h after TPA stimulation.	Tetradecanoylphorbol Acetate	129-132	protein kinase C, alpha	Mus musculus	43-52
8376369-6	1993	These results indicate that only these two members of the PKC gene family can participate in TPA-induced myeloid differentiation.	Tetradecanoylphorbol Acetate	93-96	protein kinase C, alpha	Mus musculus	58-61
8395530-4	1993	Pretreatment of the cells with TPA (10(-7) M) abolished the subsequent response to IL-1 beta, TGF-alpha, and EGF and at the same time resulted in &gt; 90% reduction of cytosolic protein kinase C activity.	Tetradecanoylphorbol Acetate	31-34	interleukin 1 beta	Rattus norvegicus	83-92
8396851-5	1993	RESULTS: Significant quantities of interleukin-8 were produced by the tissue, and the data indicate that cervical explants from pregnant and nonpregnant women behave in a similar way when challenged by phorbol myristate acetate but that the postmenopausal cervix loses its capacity for interleukin-8 production.	Tetradecanoylphorbol Acetate	202-227	C-X-C motif chemokine ligand 8	Homo sapiens	35-48
7517736-9	1993	The degradation of the fibrin clot involves the tissue-type plasminogen activator tPA, which like the uPA activates plasminogen to plasmin.	Tetradecanoylphorbol Acetate	82-85	plasminogen activator, urokinase	Homo sapiens	102-105
7517736-13	1993	On the other hand, as for uPA, tPA is inhibited by PAI-1.	Tetradecanoylphorbol Acetate	31-34	plasminogen activator, urokinase	Homo sapiens	26-29
8395912-9	1993	Differentiation induced by protein kinase C activators 12-O-tetradecanoylphorbol 13-acetate and Bryostatin 1 or by all-trans retinoic acid was associated with a decrease in MPO mRNA in all 7 initially positive cell lines studied, even leading to the complete absence of transcripts, but the enzymatic activity of the differentiated cells was only slightly less than that of unstimulated cells.	Tetradecanoylphorbol Acetate	55-91	myeloperoxidase	Homo sapiens	173-176
8260934-6	1993	The 300-kD form of DNA-PK was only detected in TPA-treated nuclear extracts, raising the possibility that cell differentiation is associated with the down-regulation and/or the inhibition of a protease(s) capable of regulating DNA-PK turnover.	Tetradecanoylphorbol Acetate	47-50	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	227-233
8359227-2	1993	A tumor promoter, TPA, induced a megakaryocyte marker, glycoprotein IIb/IIIa (GP IIb/IIIa) or IIIa (GP IIIa), but suppressed erythroid differentiation.	Tetradecanoylphorbol Acetate	18-21	integrin subunit beta 3	Homo sapiens	100-107
8243888-3	1993	Northern analysis and transient transfection assays revealed that TPA co-treatment augmented the RA-induced expression and activation of the RA nuclear receptor-beta (RAR-beta), one early marker of RA response in NT2/D1 cells.	Tetradecanoylphorbol Acetate	66-69	retinoic acid receptor beta	Homo sapiens	167-175
8245177-1	1993	In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels.	Tetradecanoylphorbol Acetate	19-50	interleukin 1 beta	Homo sapiens	94-103
8395398-7	1993	On the other hand, within 1 day of treatment, TPA inhibits the expression of the Id gene, which is a negative regulator of MyoD activity.	Tetradecanoylphorbol Acetate	46-49	myogenic differentiation 1	Homo sapiens	123-127
8395398-10	1993	These data suggest that differentiation of RD cells is likely to depend upon the activity of complexes containing the various members of the MyoD family, which can be regulated by proteins affecting MyoD dimerization such as Id, but also by other mechanisms induced by TPA, such as phosphorylation.	Tetradecanoylphorbol Acetate	269-272	myogenic differentiation 1	Homo sapiens	141-145
8365378-7	1993	Stimulation by interleukin-6 (IL-6; 200 U/ml), epidermal growth factor (4 nM), and estradiol (10(-7) M) was 2- to 3-fold, whereas stimulations by tetradecanoylphorbol-13-acetate (TPA; 80 nM) and IL-1 (10 U/ml) were 2- to 5-fold and 5- to 10-fold, respectively.	Tetradecanoylphorbol Acetate	179-182	interleukin 6	Homo sapiens	15-28
8365378-10	1993	In addition, the effects of both TPA and IL-1 could be reversed by antibody to alpha 1-AT.	Tetradecanoylphorbol Acetate	33-36	serpin family A member 1	Homo sapiens	79-89
8103055-3	1993	Preincubation with the PKC activators phorbol-12-myristate-13-acetate (PMA) (3-300 nM) or 1-oleyl-2-acetyl-glycerol (OAG) (30 microM) significantly attenuated the release of NO and PGI2 from EC stimulated with bradykinin (0.3-30 nM), whereas phorbol-12,13-didecanoate (PDD) (30-300 nM), which does not activate PKC, had no effect.	Tetradecanoylphorbol Acetate	38-69	proline rich transmembrane protein 2	Homo sapiens	23-26
8103055-3	1993	Preincubation with the PKC activators phorbol-12-myristate-13-acetate (PMA) (3-300 nM) or 1-oleyl-2-acetyl-glycerol (OAG) (30 microM) significantly attenuated the release of NO and PGI2 from EC stimulated with bradykinin (0.3-30 nM), whereas phorbol-12,13-didecanoate (PDD) (30-300 nM), which does not activate PKC, had no effect.	Tetradecanoylphorbol Acetate	38-69	proline rich transmembrane protein 2	Homo sapiens	311-314
8103055-3	1993	Preincubation with the PKC activators phorbol-12-myristate-13-acetate (PMA) (3-300 nM) or 1-oleyl-2-acetyl-glycerol (OAG) (30 microM) significantly attenuated the release of NO and PGI2 from EC stimulated with bradykinin (0.3-30 nM), whereas phorbol-12,13-didecanoate (PDD) (30-300 nM), which does not activate PKC, had no effect.	Tetradecanoylphorbol Acetate	71-74	proline rich transmembrane protein 2	Homo sapiens	23-26
8103055-9	1993	As determined by histone phosphorylation, PKC activity was similarly reduced in the cytosol, but increased in the membrane fraction of bovine EC exposed to PMA, whereas bradykinin had no significant effect.	Tetradecanoylphorbol Acetate	156-159	proline rich transmembrane protein 2	Homo sapiens	42-45
8245177-1	1993	In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels.	Tetradecanoylphorbol Acetate	19-50	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
8245177-1	1993	In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels.	Tetradecanoylphorbol Acetate	52-55	interleukin 1 beta	Homo sapiens	94-103
7504706-10	1993	The protein kinase C activator phorbol 12-myristate 13-acetate also induced Egr-1.	Tetradecanoylphorbol Acetate	31-62	early growth response 1	Rattus norvegicus	76-81
7689605-0	1993	Phorbol ester 12-O-tetradecanoylphorbol-13-acetate down-regulates expression of the c-kit proto-oncogene product.	Tetradecanoylphorbol Acetate	14-50	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	84-89
7689605-1	1993	Modulation of expression of the c-kit proto-oncogene product, the receptor for the recently identified stem cell factor, was studied on 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated cultures of CD34+ normal bone marrow progenitor cells, blast cells from patients with primary acute myelogenous leukemia, cells from the leukemia cell lines HEL and MO7E, as well as cultured HMC-1 mast cells.	Tetradecanoylphorbol Acetate	136-172	CD34 molecule	Homo sapiens	202-206
8103067-3	1993	Anti-CD3-activated CD8+ T cells did not express gp39; however, CD8+ T cells activated with PMA/ionomycin expressed gp39.	Tetradecanoylphorbol Acetate	91-94	CD40 ligand	Homo sapiens	115-119
8245177-1	1993	In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels.	Tetradecanoylphorbol Acetate	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
8245177-5	1993	PMA pretreatment of HEp-2 cells abolished PMA-induced IL-6 but the IL-1 effect was not reduced.	Tetradecanoylphorbol Acetate	0-3	interleukin 6	Homo sapiens	54-58
8402575-1	1993	The effect of modulation of protein kinase C (PKC) activity by 12-O-tetradecanoylphorbol-13-acetate (TPA) on cisplatin cytotoxicity was examined in a human osteosarcoma U2-OS cell line and in a U2-OS variant (U2-OS/Pt) selected after continuous exposure to increasing concentrations of cisplatin.	Tetradecanoylphorbol Acetate	63-99	proline rich transmembrane protein 2	Homo sapiens	46-49
8395837-3	1993	ANP also inhibited ET-1-induced translocation of protein kinase C (PKC) and TPA-induced activation of MAP kinase.	Tetradecanoylphorbol Acetate	76-79	endothelin 1	Rattus norvegicus	19-23
7689605-3	1993	Treatment of virtually all cell types with nontoxic concentrations of TPA (10(-9) M) for at least 48 h was associated with down-regulation of synthesis of c-kit transcripts and stem cell factor-receptor surface expression.	Tetradecanoylphorbol Acetate	70-73	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	155-160
7689605-4	1993	Studies on the mechanism of action of TPA utilizing the HEL erythroleukemia line showed that TPA was primarily acting by accelerating the turnover of c-kit RNA most likely through induction of a destabilizing protein.	Tetradecanoylphorbol Acetate	38-41	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	150-155
7689605-4	1993	Studies on the mechanism of action of TPA utilizing the HEL erythroleukemia line showed that TPA was primarily acting by accelerating the turnover of c-kit RNA most likely through induction of a destabilizing protein.	Tetradecanoylphorbol Acetate	93-96	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	150-155
7689605-5	1993	The effect of TPA on c-kit expression levels was independent of TPA-mediated induction of differentiation since other compounds including IFN-gamma, vitamin D3, retinoic acid, arabinofuranosylcytosine, butyric acid, and camptothecin, which also effectively induced differentiation of HEL cells, failed to alter levels of c-kit expression.	Tetradecanoylphorbol Acetate	14-17	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	21-26
8355680-10	1993	2-AP induction did not change mRNA decay rates and differed from the phorbol ester (phorbol myristate acetate)-induced activation of the protein kinase C-NF-kappa B pathway in its time course and in its requirement for new protein synthesis.	Tetradecanoylphorbol Acetate	84-109	nuclear factor kappa B subunit 1	Homo sapiens	154-164
8134164-5	1993	When treated with 12-o-tetradecanoylphorbol 13-acetate, KP-1 cells became tightly adherent, showed the enhanced reactivity for alpha-naphtyl butyrate esterase, and produced several monokines such as IL-1 beta, tumor necrosis factor-alpha, and macrophage colony-stimulating factor.	Tetradecanoylphorbol Acetate	18-54	interleukin 1 beta	Homo sapiens	199-237
8134164-7	1993	Compared with another human monocytic leukemia cell line, THP-1, KP-1 expressed scavenger receptor and accumulated cholesterol ester more rapidly in the presence of 12-o-tetradecanoyl phorbol-13-acetate and acetylated LDL.	Tetradecanoylphorbol Acetate	165-202	GLI family zinc finger 2	Homo sapiens	58-63
8402575-1	1993	The effect of modulation of protein kinase C (PKC) activity by 12-O-tetradecanoylphorbol-13-acetate (TPA) on cisplatin cytotoxicity was examined in a human osteosarcoma U2-OS cell line and in a U2-OS variant (U2-OS/Pt) selected after continuous exposure to increasing concentrations of cisplatin.	Tetradecanoylphorbol Acetate	101-104	proline rich transmembrane protein 2	Homo sapiens	28-44
8402575-1	1993	The effect of modulation of protein kinase C (PKC) activity by 12-O-tetradecanoylphorbol-13-acetate (TPA) on cisplatin cytotoxicity was examined in a human osteosarcoma U2-OS cell line and in a U2-OS variant (U2-OS/Pt) selected after continuous exposure to increasing concentrations of cisplatin.	Tetradecanoylphorbol Acetate	101-104	proline rich transmembrane protein 2	Homo sapiens	46-49
8402575-3	1993	A 24 h exposure of cells to TPA caused a potentiation of cisplatin cytotoxicity in sensitive and in resistant cells; under these conditions, PKC activity was shown to be down-regulated.	Tetradecanoylphorbol Acetate	28-31	proline rich transmembrane protein 2	Homo sapiens	141-144
8102154-8	1993	Using a three-step culture system, we next show that IL-12 induces the maturation of resting naive CD4 T cells into cells producing both IL-2 and IFN-gamma but not IL-4 upon stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	191-194	interferon gamma	Homo sapiens	146-155
8394087-3	1993	Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8.	Tetradecanoylphorbol Acetate	21-52	tumor necrosis factor	Homo sapiens	218-245
8349650-2	1993	A large variety of agents, including growth factors, the tumor promoter phorbol 12-myristate 13-acetate, and the cytokine tumor necrosis factor alpha, initiate signal transduction pathways that converge upon the NF-kappa B-I kappa B complex, resulting in the dissociation of I kappa B and the translocation of NF-kappa B to the nucleus.	Tetradecanoylphorbol Acetate	72-103	nuclear factor kappa B subunit 1	Homo sapiens	212-222
8349650-2	1993	A large variety of agents, including growth factors, the tumor promoter phorbol 12-myristate 13-acetate, and the cytokine tumor necrosis factor alpha, initiate signal transduction pathways that converge upon the NF-kappa B-I kappa B complex, resulting in the dissociation of I kappa B and the translocation of NF-kappa B to the nucleus.	Tetradecanoylphorbol Acetate	72-103	nuclear factor kappa B subunit 1	Homo sapiens	310-320
8349693-2	1993	Previously we reported that phorbol myristate acetate causes an increase in the phosphorylation state of rhodopsin in retinas exposed to a brief flash of light, with the greatest increase in phosphorylation observed at lower (&lt; or = 10%) bleach levels (Newton, A. C., and Williams, D. S. (1991) J. Biol.	Tetradecanoylphorbol Acetate	28-53	rhodopsin	Homo sapiens	105-114
8349693-5	1993	Here we show that phorbol myristate acetate causes a decrease in the phosphorylation of rhodopsin after exposure to levels of illumination that result in maximal bleaching of the visual receptor.	Tetradecanoylphorbol Acetate	18-43	rhodopsin	Homo sapiens	88-97
8393875-1	1993	Phosphorylation of threonine 1336 of the human insulin receptor (HIR) is stimulated by insulin or 4 beta-phorbol 12-myristate 13-acetate in Chinese hamster ovary (CHO) transfectant cells expressing the wild type receptor (CHO/HIR).	Tetradecanoylphorbol Acetate	98-136	insulin	Homo sapiens	47-54
8347169-2	1993	The thrombin-induced expression of PPET-1 mRNA was markedly inhibited by calphostin C, a specific inhibitor of protein kinase C, and phorbol 12-myristate 13-acetate (TPA) induced the expression of PPET-1 mRNA dose-dependently, but 4 alpha-phorbol 12, 13-didecanoate, an inactive enantiomer of phorbol ester, had no effect on the expression of PPET-1 mRNA.	Tetradecanoylphorbol Acetate	133-164	coagulation factor II, thrombin	Homo sapiens	4-12
8347169-2	1993	The thrombin-induced expression of PPET-1 mRNA was markedly inhibited by calphostin C, a specific inhibitor of protein kinase C, and phorbol 12-myristate 13-acetate (TPA) induced the expression of PPET-1 mRNA dose-dependently, but 4 alpha-phorbol 12, 13-didecanoate, an inactive enantiomer of phorbol ester, had no effect on the expression of PPET-1 mRNA.	Tetradecanoylphorbol Acetate	133-164	endothelin 1	Homo sapiens	35-41
8347169-2	1993	The thrombin-induced expression of PPET-1 mRNA was markedly inhibited by calphostin C, a specific inhibitor of protein kinase C, and phorbol 12-myristate 13-acetate (TPA) induced the expression of PPET-1 mRNA dose-dependently, but 4 alpha-phorbol 12, 13-didecanoate, an inactive enantiomer of phorbol ester, had no effect on the expression of PPET-1 mRNA.	Tetradecanoylphorbol Acetate	133-164	plasminogen activator, tissue type	Homo sapiens	166-169
8347169-2	1993	The thrombin-induced expression of PPET-1 mRNA was markedly inhibited by calphostin C, a specific inhibitor of protein kinase C, and phorbol 12-myristate 13-acetate (TPA) induced the expression of PPET-1 mRNA dose-dependently, but 4 alpha-phorbol 12, 13-didecanoate, an inactive enantiomer of phorbol ester, had no effect on the expression of PPET-1 mRNA.	Tetradecanoylphorbol Acetate	133-164	endothelin 1	Homo sapiens	197-203
8347169-2	1993	The thrombin-induced expression of PPET-1 mRNA was markedly inhibited by calphostin C, a specific inhibitor of protein kinase C, and phorbol 12-myristate 13-acetate (TPA) induced the expression of PPET-1 mRNA dose-dependently, but 4 alpha-phorbol 12, 13-didecanoate, an inactive enantiomer of phorbol ester, had no effect on the expression of PPET-1 mRNA.	Tetradecanoylphorbol Acetate	133-164	endothelin 1	Homo sapiens	197-203
8394087-3	1993	Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8.	Tetradecanoylphorbol Acetate	21-52	tumor necrosis factor	Homo sapiens	247-256
8394087-3	1993	Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8.	Tetradecanoylphorbol Acetate	21-52	interleukin 1 beta	Homo sapiens	259-282
8394087-3	1993	Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8.	Tetradecanoylphorbol Acetate	21-52	C-X-C motif chemokine ligand 8	Homo sapiens	287-291
7687899-7	1993	However, incubation with phorbol 12-myristate 13 acetate (PMA), induced a marked increase in MIRL RNA as determined by Northern blot analysis.	Tetradecanoylphorbol Acetate	25-56	CD59 molecule (CD59 blood group)	Homo sapiens	93-97
7687899-7	1993	However, incubation with phorbol 12-myristate 13 acetate (PMA), induced a marked increase in MIRL RNA as determined by Northern blot analysis.	Tetradecanoylphorbol Acetate	58-61	CD59 molecule (CD59 blood group)	Homo sapiens	93-97
8398910-3	1993	It is reported here that IL-6 elevated the junB and c-jun mRNA levels and induced the formation of a novel DNA-protein complex with high sequence specificity to 12-O-tetradecanoylphorbol-13-acetate response element (TRE) oligonucleotides.	Tetradecanoylphorbol Acetate	161-197	interleukin 6	Homo sapiens	25-29
8348742-1	1993	During the phorbol myristate acetate (PMA)-induced differentiation of U937 cells to a macrophage-like phenotype, the levels of the heat shock proteins hsp90, hsp72 and hsp65 increased dramatically to a peak level following 24 h of treatment, and then declined.	Tetradecanoylphorbol Acetate	11-36	heat shock protein family A (Hsp70) member 1A	Homo sapiens	158-163
8348742-1	1993	During the phorbol myristate acetate (PMA)-induced differentiation of U937 cells to a macrophage-like phenotype, the levels of the heat shock proteins hsp90, hsp72 and hsp65 increased dramatically to a peak level following 24 h of treatment, and then declined.	Tetradecanoylphorbol Acetate	38-41	heat shock protein family A (Hsp70) member 1A	Homo sapiens	158-163
8354273-1	1993	Exposure of human breast cancer cells (MCF-7) to tumor promoters such as 12-O-tetradecanoyl phorbol 13-acetate (TPA) for 24 h at concentrations of 1-100 nM resulted in marked inhibition of DNA synthesis but a 3-5-fold increase in the amount of pS2 protein in the medium.	Tetradecanoylphorbol Acetate	73-110	taste 2 receptor member 64 pseudogene	Homo sapiens	244-247
8354273-1	1993	Exposure of human breast cancer cells (MCF-7) to tumor promoters such as 12-O-tetradecanoyl phorbol 13-acetate (TPA) for 24 h at concentrations of 1-100 nM resulted in marked inhibition of DNA synthesis but a 3-5-fold increase in the amount of pS2 protein in the medium.	Tetradecanoylphorbol Acetate	112-115	taste 2 receptor member 64 pseudogene	Homo sapiens	244-247
8354273-4	1993	The increase in the pS2 protein content of the medium by TPA was inhibited by simultaneous addition of cycloheximide, but not by that of actinomycin D.	Tetradecanoylphorbol Acetate	57-60	taste 2 receptor member 64 pseudogene	Homo sapiens	20-23
8354273-5	1993	Northern-blot hybridization analysis showed that the amount of pS2 mRNA was unchanged by treatment of the cells with TPA.	Tetradecanoylphorbol Acetate	117-120	taste 2 receptor member 64 pseudogene	Homo sapiens	63-66
8354273-6	1993	These results indicate that TPA does not induce transcription of the pS2 gene, and suggest that the main effect of TPA results from the induction of translation of pS2 mRNA.	Tetradecanoylphorbol Acetate	115-118	taste 2 receptor member 64 pseudogene	Homo sapiens	164-167
8375736-2	1993	In order to determine whether the cytolytic activity induced by IFN alpha was activated through a pathway involving the activation of PKC, the human ovarian carcinoma cell line Caov-3 was exposed to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	232-235	interferon alpha 1	Homo sapiens	64-73
7693024-4	1993	When the cells were cultured with 12-o-tetradecanoylphorbol-13-acetate (TPA), the expression of TSP was enhanced and vWF was also detected, but not Fbg.	Tetradecanoylphorbol Acetate	72-75	thrombospondin 1	Homo sapiens	96-99
8375736-2	1993	In order to determine whether the cytolytic activity induced by IFN alpha was activated through a pathway involving the activation of PKC, the human ovarian carcinoma cell line Caov-3 was exposed to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	199-230	interferon alpha 1	Homo sapiens	64-73
7693024-4	1993	When the cells were cultured with 12-o-tetradecanoylphorbol-13-acetate (TPA), the expression of TSP was enhanced and vWF was also detected, but not Fbg.	Tetradecanoylphorbol Acetate	34-70	thrombospondin 1	Homo sapiens	96-99
7693024-4	1993	When the cells were cultured with 12-o-tetradecanoylphorbol-13-acetate (TPA), the expression of TSP was enhanced and vWF was also detected, but not Fbg.	Tetradecanoylphorbol Acetate	72-75	von Willebrand factor	Homo sapiens	117-120
7693024-4	1993	When the cells were cultured with 12-o-tetradecanoylphorbol-13-acetate (TPA), the expression of TSP was enhanced and vWF was also detected, but not Fbg.	Tetradecanoylphorbol Acetate	34-70	von Willebrand factor	Homo sapiens	117-120
8227206-5	1993	Analysis by immunoblotting of the PK-C isoforms present in HT-29 M6 cells revealed that the most abundant TPA-sensitive isoform was PK-C epsilon, although low levels of cPK-C were also detected.	Tetradecanoylphorbol Acetate	106-109	proline rich transmembrane protein 2	Homo sapiens	34-38
8406577-3	1993	The augmentation by GL of IL-2 production was also found in spleen cells stimulated with A23187 plus phorbol 12-myristate 13-acetate (PMA), suggesting that GL primarily affects some post-receptor stage of the signal transduction.	Tetradecanoylphorbol Acetate	101-132	interleukin 2	Homo sapiens	26-30
8406577-3	1993	The augmentation by GL of IL-2 production was also found in spleen cells stimulated with A23187 plus phorbol 12-myristate 13-acetate (PMA), suggesting that GL primarily affects some post-receptor stage of the signal transduction.	Tetradecanoylphorbol Acetate	134-137	interleukin 2	Homo sapiens	26-30
8227206-5	1993	Analysis by immunoblotting of the PK-C isoforms present in HT-29 M6 cells revealed that the most abundant TPA-sensitive isoform was PK-C epsilon, although low levels of cPK-C were also detected.	Tetradecanoylphorbol Acetate	106-109	proline rich transmembrane protein 2	Homo sapiens	132-136
8360592-5	1993	While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed.	Tetradecanoylphorbol Acetate	6-31	interleukin 1 beta	Homo sapiens	40-49
8360592-5	1993	While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed.	Tetradecanoylphorbol Acetate	6-31	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
8360592-5	1993	While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed.	Tetradecanoylphorbol Acetate	6-31	interleukin 6	Homo sapiens	96-100
8360592-5	1993	While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed.	Tetradecanoylphorbol Acetate	6-31	interleukin 6	Homo sapiens	229-233
8393086-3	1993	NG-G11 cells expressed GAP-43 mRNA at levels approximately twice that in nontransfected or vector-transfected cells under control conditions and after treatment with dibutyryl cyclic AMP (diBu-cAMP) or 12-O-tetradecanoylphorbol 13-acetate (TPA) plus diBu-cAMP.	Tetradecanoylphorbol Acetate	202-238	growth associated protein 43	Mus musculus	23-29
8344464-7	1993	The protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induces src+ mRNA expression in cultured stage 10+ animal cap ectoderm.	Tetradecanoylphorbol Acetate	37-73	SRC proto-oncogene, non-receptor tyrosine kinase L homeolog	Xenopus laevis	88-92
8393086-3	1993	NG-G11 cells expressed GAP-43 mRNA at levels approximately twice that in nontransfected or vector-transfected cells under control conditions and after treatment with dibutyryl cyclic AMP (diBu-cAMP) or 12-O-tetradecanoylphorbol 13-acetate (TPA) plus diBu-cAMP.	Tetradecanoylphorbol Acetate	240-243	growth associated protein 43	Mus musculus	23-29
8344464-7	1993	The protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induces src+ mRNA expression in cultured stage 10+ animal cap ectoderm.	Tetradecanoylphorbol Acetate	75-78	SRC proto-oncogene, non-receptor tyrosine kinase L homeolog	Xenopus laevis	88-92
8344464-8	1993	This induction is rapid, with src+ mRNA being detected within 1 hr of TPA addition.	Tetradecanoylphorbol Acetate	70-73	SRC proto-oncogene, non-receptor tyrosine kinase L homeolog	Xenopus laevis	30-34
8336714-5	1993	It was found that phorbol myristate acetate, (PMA) which is a potent stimulant of phorbol ester-sensitive PKC isotypes, activates NF-kappa B.	Tetradecanoylphorbol Acetate	18-43	nuclear factor kappa B subunit 1	Homo sapiens	130-140
8344464-9	1993	Only dorsal ectoderm tissue is competent to express src+ mRNA upon TPA treatment, and stage 10+ ectoderm tissue becomes unresponsive to TPA after 4 hr in culture.	Tetradecanoylphorbol Acetate	67-70	SRC proto-oncogene, non-receptor tyrosine kinase L homeolog	Xenopus laevis	52-56
8344464-10	1993	TPA-dependent induction of src+ mRNA in ectoderm tissue is not blocked by cycloheximide and therefore is not dependent on protein synthesis.	Tetradecanoylphorbol Acetate	0-3	SRC proto-oncogene, non-receptor tyrosine kinase L homeolog	Xenopus laevis	27-31
8336714-5	1993	It was found that phorbol myristate acetate, (PMA) which is a potent stimulant of phorbol ester-sensitive PKC isotypes, activates NF-kappa B.	Tetradecanoylphorbol Acetate	46-49	nuclear factor kappa B subunit 1	Homo sapiens	130-140
8233727-11	1993	Considering the low proportion of lymphocytes, stimulation with phorbol myristate acetate in combination with ionomycin resulted in considerable production of the following lymphokines: IL-2, IL-3, IL-4, IL-10, interferon-gamma, tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	64-89	interleukin 2	Homo sapiens	186-190
8233727-11	1993	Considering the low proportion of lymphocytes, stimulation with phorbol myristate acetate in combination with ionomycin resulted in considerable production of the following lymphokines: IL-2, IL-3, IL-4, IL-10, interferon-gamma, tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	64-89	interleukin 4	Homo sapiens	198-202
8233727-11	1993	Considering the low proportion of lymphocytes, stimulation with phorbol myristate acetate in combination with ionomycin resulted in considerable production of the following lymphokines: IL-2, IL-3, IL-4, IL-10, interferon-gamma, tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	64-89	interferon gamma	Homo sapiens	211-256
8346236-4	1993	Three transcripts (xip4, -7, and -12) were induced only by ionizing radiation, and many (i.e., xip1, -2, -3, -5, -6, -8, -9, -10, and -11) were also induced by UV irradiation or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	178-209	aprataxin and PNKP like factor	Homo sapiens	95-137
8210444-6	1993	IL-2 enhanced the stimulatory actions of interleukin-1 (IL-1), epidermal growth factor (EGF), ionomycin, and phorbol 12-myristate 13-acetate (PMA) on PGE2 production by decidual cells.	Tetradecanoylphorbol Acetate	109-140	interleukin 2	Homo sapiens	0-4
8210444-6	1993	IL-2 enhanced the stimulatory actions of interleukin-1 (IL-1), epidermal growth factor (EGF), ionomycin, and phorbol 12-myristate 13-acetate (PMA) on PGE2 production by decidual cells.	Tetradecanoylphorbol Acetate	142-145	interleukin 2	Homo sapiens	0-4
8346015-0	1993	Cytoskeletal reorganization and TPA differently modify AP-1 to induce the urokinase-type plasminogen activator gene in LLC-PK1 cells.	Tetradecanoylphorbol Acetate	32-35	plasminogen activator, urokinase	Sus scrofa	74-110
8340409-5	1993	PMA-induced differentiation and cytostasis lead to a decrease in beta II PKC and increases in alpha and zeta PKC levels.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	73-76
8340409-5	1993	PMA-induced differentiation and cytostasis lead to a decrease in beta II PKC and increases in alpha and zeta PKC levels.	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	109-112
8340409-7	1993	K562 cells overexpressing human alpha PKC grew more slowly and were more sensitive to the cytostatic effects of PMA than control cells, whereas cells overexpressing beta II PKC were less sensitive to PMA.	Tetradecanoylphorbol Acetate	112-115	proline rich transmembrane protein 2	Homo sapiens	38-41
8346015-5	1993	12-O-tetradecanoylphorbol 13-acetate (TPA) induces the uPA gene through the same elements, but additionally utilizes an adjacent PEA3 element and induces c-fos.	Tetradecanoylphorbol Acetate	0-36	plasminogen activator, urokinase	Sus scrofa	55-58
8346015-5	1993	12-O-tetradecanoylphorbol 13-acetate (TPA) induces the uPA gene through the same elements, but additionally utilizes an adjacent PEA3 element and induces c-fos.	Tetradecanoylphorbol Acetate	38-41	plasminogen activator, urokinase	Sus scrofa	55-58
7687618-0	1993	Functionally anergic lpr and gld B220+ T cell receptor (TCR)-alpha/beta+ double-negative T cells express CD28 and respond to costimulation with phorbol myristate acetate and antibodies to CD28 and the TCR.	Tetradecanoylphorbol Acetate	144-169	Fas (TNF receptor superfamily member 6)	Mus musculus	21-24
8393449-13	1993	Stimulation of protein kinase C with phorbol 12-myristate-13-acetate (PMA, 1 microM) enhanced the response to thrombin.	Tetradecanoylphorbol Acetate	37-68	coagulation factor II, thrombin	Homo sapiens	110-118
8393449-13	1993	Stimulation of protein kinase C with phorbol 12-myristate-13-acetate (PMA, 1 microM) enhanced the response to thrombin.	Tetradecanoylphorbol Acetate	70-73	coagulation factor II, thrombin	Homo sapiens	110-118
8321321-1	1993	The kinase Raf-1 can be activated by treatment of cells with mitogens and by the protein kinase C (PKC) activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) (reviewed in refs 1,2).	Tetradecanoylphorbol Acetate	114-151	protein kinase C, alpha	Mus musculus	99-102
8321321-1	1993	The kinase Raf-1 can be activated by treatment of cells with mitogens and by the protein kinase C (PKC) activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) (reviewed in refs 1,2).	Tetradecanoylphorbol Acetate	153-156	protein kinase C, alpha	Mus musculus	99-102
8263960-5	1993	To evaluate the role of PKC in this process, normal coronary rings pretreated for a period of one hour with the phorbol ester, phorbol 12-myristate 13-acetate (PMA, 1 microM), resulted in a similar attenuation (36%) of ET-1 production of inositol phosphates.	Tetradecanoylphorbol Acetate	127-158	endothelin 1	Canis lupus familiaris	219-223
8263960-5	1993	To evaluate the role of PKC in this process, normal coronary rings pretreated for a period of one hour with the phorbol ester, phorbol 12-myristate 13-acetate (PMA, 1 microM), resulted in a similar attenuation (36%) of ET-1 production of inositol phosphates.	Tetradecanoylphorbol Acetate	160-163	endothelin 1	Canis lupus familiaris	219-223
7694073-2	1993	Here we show that PMA induces c-fos with similar kinetics when compared with ACTH (0.5-1 h peak) but reaches only 60% of the maximal ACTH induction and dcAMP is a weak c-fos inducer (15% of ACTH).	Tetradecanoylphorbol Acetate	18-21	proopiomelanocortin	Homo sapiens	133-137
8344313-1	1993	The activation of phospholipase D (PLD) by platelet-derived growth factor (PDGF), prostaglandin F2 alpha and 12-O-tetradecanoylphorbol 13-acetate (TPA) was studied in NIH-3T3 fibroblasts.	Tetradecanoylphorbol Acetate	109-145	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	18-33
8344313-1	1993	The activation of phospholipase D (PLD) by platelet-derived growth factor (PDGF), prostaglandin F2 alpha and 12-O-tetradecanoylphorbol 13-acetate (TPA) was studied in NIH-3T3 fibroblasts.	Tetradecanoylphorbol Acetate	109-145	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	35-38
8344313-1	1993	The activation of phospholipase D (PLD) by platelet-derived growth factor (PDGF), prostaglandin F2 alpha and 12-O-tetradecanoylphorbol 13-acetate (TPA) was studied in NIH-3T3 fibroblasts.	Tetradecanoylphorbol Acetate	147-150	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	18-33
8344313-1	1993	The activation of phospholipase D (PLD) by platelet-derived growth factor (PDGF), prostaglandin F2 alpha and 12-O-tetradecanoylphorbol 13-acetate (TPA) was studied in NIH-3T3 fibroblasts.	Tetradecanoylphorbol Acetate	147-150	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	35-38
8344313-5	1993	In contrast, TPA-induced activation of PLD was sustained for at least 60 min of incubation.	Tetradecanoylphorbol Acetate	13-16	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	39-42
8344313-6	1993	A combination of maximally effective concentrations of PDGF and TPA stimulated PLD activity in a non-additive manner, while the effect of prostaglandin F2 alpha was additional to that of either PDGF or TPA.	Tetradecanoylphorbol Acetate	64-67	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	79-82
8344313-7	1993	The protein kinase inhibitor staurosporine inhibited PLD activation by PDGF or TPA with almost identical dose/response curves.	Tetradecanoylphorbol Acetate	79-82	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	53-56
8344313-9	1993	The specific protein kinase C inhibitor GF109203X (a bisindolylmaleimide) inhibited PLD activation by prostaglandin F2 alpha and PDGF at concentrations higher than those required for inhibition of PLD activation induced by TPA.	Tetradecanoylphorbol Acetate	223-226	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	84-87
7686146-1	1993	Expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in epithelial cells is known to be down-regulated by the action of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	144-169	CF transmembrane conductance regulator	Homo sapiens	18-69
7686146-1	1993	Expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in epithelial cells is known to be down-regulated by the action of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	144-169	CF transmembrane conductance regulator	Homo sapiens	71-75
7686146-1	1993	Expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in epithelial cells is known to be down-regulated by the action of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	171-174	CF transmembrane conductance regulator	Homo sapiens	18-69
7686146-1	1993	Expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in epithelial cells is known to be down-regulated by the action of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	171-174	CF transmembrane conductance regulator	Homo sapiens	71-75
8391998-5	1993	The peptide (100 microM) also inhibited LH and GH exocytosis stimulated by phorbol myristate acetate plus cAMP by more than 45% and 80%, respectively.	Tetradecanoylphorbol Acetate	75-100	growth hormone 1	Homo sapiens	47-49
7694073-2	1993	Here we show that PMA induces c-fos with similar kinetics when compared with ACTH (0.5-1 h peak) but reaches only 60% of the maximal ACTH induction and dcAMP is a weak c-fos inducer (15% of ACTH).	Tetradecanoylphorbol Acetate	18-21	proopiomelanocortin	Homo sapiens	133-137
8232274-8	1993	In addition, we show that like the ANF-R1A, the ANF-R1C guanylyl cyclase activity can be regulated by phosphorylation since preincubation with TPA or FKL attenuates the subsequent stimulation by CNP in cultured cells.	Tetradecanoylphorbol Acetate	143-146	natriuretic peptide A	Homo sapiens	35-38
7686146-3	1993	HT-29 colon epithelial cells and the CFTR-transfected pancreatic cells PLJ-4.7 lost 55-80% of their CFTR protein after 3-6 h of treatment with 100 nM PMA, as analyzed by quantitative Western blotting.	Tetradecanoylphorbol Acetate	150-153	CF transmembrane conductance regulator	Homo sapiens	37-41
7686146-3	1993	HT-29 colon epithelial cells and the CFTR-transfected pancreatic cells PLJ-4.7 lost 55-80% of their CFTR protein after 3-6 h of treatment with 100 nM PMA, as analyzed by quantitative Western blotting.	Tetradecanoylphorbol Acetate	150-153	CF transmembrane conductance regulator	Homo sapiens	100-104
8232274-8	1993	In addition, we show that like the ANF-R1A, the ANF-R1C guanylyl cyclase activity can be regulated by phosphorylation since preincubation with TPA or FKL attenuates the subsequent stimulation by CNP in cultured cells.	Tetradecanoylphorbol Acetate	143-146	natriuretic peptide A	Homo sapiens	48-51
8373725-6	1993	Bradykinin-stimulated release of arachidonic acid was prevented by down-regulating protein kinase C by pretreatment with phorbol 12-myristate 13-acetate and was unaffected by inhibitors of protein synthesis actinomycin D or cycloheximide.	Tetradecanoylphorbol Acetate	121-152	kininogen 1	Homo sapiens	0-10
8100719-4	1993	When stimulated with anti-CD3 and phorbol 12-myristate 13-acetate, purified patient CD8+ T cells exhibited significantly decreased proliferation, c-myc expression, and interleukin-2 (IL-2) production compared with that of normal CD8+ T cells.	Tetradecanoylphorbol Acetate	34-65	interleukin 2	Homo sapiens	168-181
8100719-4	1993	When stimulated with anti-CD3 and phorbol 12-myristate 13-acetate, purified patient CD8+ T cells exhibited significantly decreased proliferation, c-myc expression, and interleukin-2 (IL-2) production compared with that of normal CD8+ T cells.	Tetradecanoylphorbol Acetate	34-65	interleukin 2	Homo sapiens	183-187
7686147-3	1993	However, 12-O-tetradecanoylphorbol-13-acetate and forskolin, which trigger the protein kinase C- and A-dependent signal transduction pathways, respectively, are potent inducers of MUC2 gene expression.	Tetradecanoylphorbol Acetate	9-45	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	180-184
8314805-2	1993	We report here that expression directed by a junB promoter/chloramphenicol acetyltransferase reporter construct (junB/CAT) is induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor in mouse fibroblast 3T6 cells.	Tetradecanoylphorbol Acetate	157-193	catalase	Mus musculus	118-121
8314805-2	1993	We report here that expression directed by a junB promoter/chloramphenicol acetyltransferase reporter construct (junB/CAT) is induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor in mouse fibroblast 3T6 cells.	Tetradecanoylphorbol Acetate	195-198	catalase	Mus musculus	118-121
8319811-3	1993	Bacterial lipopolysaccharide endotoxin (LPS) or phorbol myristate acetate (PMA) alone induced suboptimal expression as assessed by Northern blotting; however, preincubation of cells with PMA followed by endotoxin induced much higher levels of IL-8 mRNA.	Tetradecanoylphorbol Acetate	48-73	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
8319811-3	1993	Bacterial lipopolysaccharide endotoxin (LPS) or phorbol myristate acetate (PMA) alone induced suboptimal expression as assessed by Northern blotting; however, preincubation of cells with PMA followed by endotoxin induced much higher levels of IL-8 mRNA.	Tetradecanoylphorbol Acetate	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
8319811-3	1993	Bacterial lipopolysaccharide endotoxin (LPS) or phorbol myristate acetate (PMA) alone induced suboptimal expression as assessed by Northern blotting; however, preincubation of cells with PMA followed by endotoxin induced much higher levels of IL-8 mRNA.	Tetradecanoylphorbol Acetate	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	243-247
8328965-4	1993	Treatment of THP-1 cells for 1-72 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) led to a stable enzyme activation, which was also found after partial purification of PLA2 from PMA-stimulated THP-1 cells.	Tetradecanoylphorbol Acetate	59-90	GLI family zinc finger 2	Homo sapiens	13-18
8328965-4	1993	Treatment of THP-1 cells for 1-72 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) led to a stable enzyme activation, which was also found after partial purification of PLA2 from PMA-stimulated THP-1 cells.	Tetradecanoylphorbol Acetate	59-90	GLI family zinc finger 2	Homo sapiens	208-213
8328965-4	1993	Treatment of THP-1 cells for 1-72 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) led to a stable enzyme activation, which was also found after partial purification of PLA2 from PMA-stimulated THP-1 cells.	Tetradecanoylphorbol Acetate	92-95	GLI family zinc finger 2	Homo sapiens	13-18
8328965-4	1993	Treatment of THP-1 cells for 1-72 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) led to a stable enzyme activation, which was also found after partial purification of PLA2 from PMA-stimulated THP-1 cells.	Tetradecanoylphorbol Acetate	92-95	GLI family zinc finger 2	Homo sapiens	208-213
8324227-10	1993	In addition, pretreatment of neutrophils with 10 nmol/L phorbol myristate acetate (PMA) resulted in approximately a 50% reduction in the amount of DBP in both the specific granule and plasma-membrane fractions.	Tetradecanoylphorbol Acetate	56-81	D-box binding PAR bZIP transcription factor	Homo sapiens	147-150
8324227-10	1993	In addition, pretreatment of neutrophils with 10 nmol/L phorbol myristate acetate (PMA) resulted in approximately a 50% reduction in the amount of DBP in both the specific granule and plasma-membrane fractions.	Tetradecanoylphorbol Acetate	83-86	D-box binding PAR bZIP transcription factor	Homo sapiens	147-150
8324227-11	1993	Finally, analysis of the cell-free supernates showed that DBP was spontaneously released into the extracellular milieu: moreover, this release was enhanced if the cells were first stimulated with C5a, formyl-norleucyl-leucyl-phenylalanine (fNLP) or PMA.	Tetradecanoylphorbol Acetate	249-252	D-box binding PAR bZIP transcription factor	Homo sapiens	58-61
8398898-8	1993	We conclude that 15 nM TPA treatment of K562 cells initiates effects that simultaneously interfere with the phosphorylation of p160 BCR in BCR-ABL complexes and inactivates the autophosphorylation activity of the full length BCR-ABL protein.	Tetradecanoylphorbol Acetate	23-26	MYB binding protein 1a	Homo sapiens	127-131
7686495-4	1993	When 0.3 ng/ml of phorbol 12-myristate 13-acetate (PMA) was added together with TGF-beta 1, TGF-beta 1 inhibited growth of PC-3 cells (about 50% inhibition), and the growth inhibitory activity of TGF-beta 1 in PC-3U cells was enhanced (more than 90% inhibition).	Tetradecanoylphorbol Acetate	18-49	transforming growth factor beta 1	Homo sapiens	92-102
8149696-6	1993	The role of protein kinase C and protein tyrosine kinases in arginine-vasopressin mitogenicity was assessed by stimulating the cells with arginine-vasopressin in the presence of 12-O-tetradecanoylphorbol 13-acetate and tyrphostin (a tyrosine kinase inhibitor), respectively.	Tetradecanoylphorbol Acetate	178-214	arginine vasopressin	Rattus norvegicus	70-81
8149696-9	1993	The presence of 12-O-tetradecanoylphorbol 13-acetate markedly decreased arginine-vasopressin-induced [3H]thymidine incorporation in fibroblasts from spontaneously hypertensive rats and was without effect in fibroblasts from Wistar-Kyoto rats.	Tetradecanoylphorbol Acetate	16-52	arginine vasopressin	Rattus norvegicus	81-92
7686495-4	1993	When 0.3 ng/ml of phorbol 12-myristate 13-acetate (PMA) was added together with TGF-beta 1, TGF-beta 1 inhibited growth of PC-3 cells (about 50% inhibition), and the growth inhibitory activity of TGF-beta 1 in PC-3U cells was enhanced (more than 90% inhibition).	Tetradecanoylphorbol Acetate	18-49	transforming growth factor beta 1	Homo sapiens	92-102
7686495-4	1993	When 0.3 ng/ml of phorbol 12-myristate 13-acetate (PMA) was added together with TGF-beta 1, TGF-beta 1 inhibited growth of PC-3 cells (about 50% inhibition), and the growth inhibitory activity of TGF-beta 1 in PC-3U cells was enhanced (more than 90% inhibition).	Tetradecanoylphorbol Acetate	51-54	transforming growth factor beta 1	Homo sapiens	92-102
7686495-4	1993	When 0.3 ng/ml of phorbol 12-myristate 13-acetate (PMA) was added together with TGF-beta 1, TGF-beta 1 inhibited growth of PC-3 cells (about 50% inhibition), and the growth inhibitory activity of TGF-beta 1 in PC-3U cells was enhanced (more than 90% inhibition).	Tetradecanoylphorbol Acetate	51-54	transforming growth factor beta 1	Homo sapiens	92-102
7901231-8	1993	Furthermore, stimulation of both CVI patient and normal CD4+ T cells with either ionomycin+phorbol myristate acetate or a combination of immobilized anti-CD3 antibody plus anti-CD28 antibody resulted in a 50-fold increase in IL-2 production compared to stimulation with immobilized anti-CD3 antibody alone, and, under these conditions, CVI and normal CD4+ T cells produced equivalent amounts of IL-2.	Tetradecanoylphorbol Acetate	91-116	CD4 molecule	Homo sapiens	56-59
7901231-8	1993	Furthermore, stimulation of both CVI patient and normal CD4+ T cells with either ionomycin+phorbol myristate acetate or a combination of immobilized anti-CD3 antibody plus anti-CD28 antibody resulted in a 50-fold increase in IL-2 production compared to stimulation with immobilized anti-CD3 antibody alone, and, under these conditions, CVI and normal CD4+ T cells produced equivalent amounts of IL-2.	Tetradecanoylphorbol Acetate	91-116	interleukin 2	Homo sapiens	225-229
8326129-7	1993	Exposure of the fibroblasts to phorbol-12-myristate-13-acetate (PMA) for 24 h, which is known to deplete PKC, also decreased the numbers of base line IL-1 binding sites.	Tetradecanoylphorbol Acetate	31-62	proline rich transmembrane protein 2	Homo sapiens	105-108
8326007-5	1993	Tetradecanoylphorbol-acetate (10(-7) M) mimicked the effects of ANG II and ET-1 on induction of ppET-1 mRNA.	Tetradecanoylphorbol Acetate	0-28	angiotensinogen	Rattus norvegicus	64-70
8326007-5	1993	Tetradecanoylphorbol-acetate (10(-7) M) mimicked the effects of ANG II and ET-1 on induction of ppET-1 mRNA.	Tetradecanoylphorbol Acetate	0-28	endothelin 1	Rattus norvegicus	75-79
8326007-5	1993	Tetradecanoylphorbol-acetate (10(-7) M) mimicked the effects of ANG II and ET-1 on induction of ppET-1 mRNA.	Tetradecanoylphorbol Acetate	0-28	endothelin 1	Rattus norvegicus	96-102
8326129-7	1993	Exposure of the fibroblasts to phorbol-12-myristate-13-acetate (PMA) for 24 h, which is known to deplete PKC, also decreased the numbers of base line IL-1 binding sites.	Tetradecanoylphorbol Acetate	64-67	proline rich transmembrane protein 2	Homo sapiens	105-108
8399068-8	1993	Bryo inhibited the TPA action on NSE and CD10.	Tetradecanoylphorbol Acetate	19-22	membrane metalloendopeptidase	Homo sapiens	41-45
8264851-1	1993	We have previously shown that the abilities of the two native goldfish GnRHs, salmon GnRH (sGnRH) and chicken GnRH II (cGnRH II), to stimulate gonadotropin (GtH) secretion and elevate intracellular Ca2+ levels are mimicked by the protein kinase C (PKC) stimulators, 1,2-dioctanoylglycerol (DiC8) and 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	300-337	mitochondrial ribosomal protein S26	Gallus gallus	110-117
8264851-1	1993	We have previously shown that the abilities of the two native goldfish GnRHs, salmon GnRH (sGnRH) and chicken GnRH II (cGnRH II), to stimulate gonadotropin (GtH) secretion and elevate intracellular Ca2+ levels are mimicked by the protein kinase C (PKC) stimulators, 1,2-dioctanoylglycerol (DiC8) and 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	339-342	mitochondrial ribosomal protein S26	Gallus gallus	110-117
8509396-4	1993	Accumulation of [3H]phosphatidylpropanol in response to platelet-derived growth factor and 12-O-tetradecanoylphorbol-13-acetate was 2-3-fold greater in protein kinase C-alpha-overexpressing SF1.4 cells compared with the vector control cells, SC1.	Tetradecanoylphorbol Acetate	91-127	protein kinase C, alpha	Mus musculus	152-174
8413316-5	1993	Our results show that phorbol 12-myristate 13-acetate (TPA) activates rPRL promoter activity through PKC, and that TPA activation of PKC diminishes the Ras response in a dose-dependent manner.	Tetradecanoylphorbol Acetate	22-53	prolactin	Rattus norvegicus	70-74
8413316-5	1993	Our results show that phorbol 12-myristate 13-acetate (TPA) activates rPRL promoter activity through PKC, and that TPA activation of PKC diminishes the Ras response in a dose-dependent manner.	Tetradecanoylphorbol Acetate	55-58	prolactin	Rattus norvegicus	70-74
8413316-8	1993	Finally, cotransfection of a c-Jun expression vector results in inhibition of basal, TPA, and oncogenic Ras-stimulated activity of the rPRL promoter.	Tetradecanoylphorbol Acetate	85-88	prolactin	Rattus norvegicus	135-139
8389757-8	1993	Other studies further demonstrate that the jun-B and fra-1 genes are induced by TPA in both HL-60/vinc and HL-60/vinc/R cells, whereas c-fos expression is attenuated in the HL-60/vinc line.	Tetradecanoylphorbol Acetate	80-83	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	43-48
8397123-8	1993	In contrast, in the presence of a co-transfected glucocorticoid receptor cDNA expression plasmid, DEX augmented TPA-stimulated CAT expression by approximately 3.1-fold.	Tetradecanoylphorbol Acetate	112-115	nuclear receptor subfamily 3 group C member 1	Homo sapiens	49-72
8323980-4	1993	The phorbol ester, 12-O-tetradeconoylphorbol 13-acetate (TPA), cannot support growth of these cells, is a more effective inducer than insulin of c-fos, c-myc, c-jun, jun-B, Krox-20, Krox 24, fra-1 and JE, and induces fra-1, JE and c-myc with different kinetics from those of insulin.	Tetradecanoylphorbol Acetate	57-60	insulin	Cricetulus griseus	275-282
8323980-7	1993	These results, together with other experiments, demonstrate that [1] the insulin signal is independent of PKC, [2] insulin acts as a weak competence and a strong progression factor, while TPA behaves as a strong competence factor, and [3] the 9-10-h lag is made up of a 3-h period which is independent of protein synthesis, advancing the cells to a post-G(o) state of "competence".	Tetradecanoylphorbol Acetate	188-191	insulin	Cricetulus griseus	73-80
8504157-3	1993	The PLD was shown to be activated by phorbol, 12-myristate, 13-acetate (PMA), calcium ionophore A23187, oxytocin, bombesin and bradykinin, but not by platelet-activating factor (PAF) and epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	72-75	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-7
8504157-8	1993	The PA synthesis caused by the two stimulators was similarly inhibited by staurosporine and by a chronic treatment with PMA (100 nM for 24 h), suggesting that the activation of PLD is linked to the action of protein kinase C. With the cells labeled with radioactive choline and ethanolamine, we found that the amniotic PLD hydrolyzed almost equally phosphatidylcholine and phosphatidylethanolamine.	Tetradecanoylphorbol Acetate	120-123	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	177-180
8504157-8	1993	The PA synthesis caused by the two stimulators was similarly inhibited by staurosporine and by a chronic treatment with PMA (100 nM for 24 h), suggesting that the activation of PLD is linked to the action of protein kinase C. With the cells labeled with radioactive choline and ethanolamine, we found that the amniotic PLD hydrolyzed almost equally phosphatidylcholine and phosphatidylethanolamine.	Tetradecanoylphorbol Acetate	120-123	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	319-322
8396623-3	1993	ACTH enhanced IGF-II mRNA accumulation dose- and time-dependently, maximally four- to sixfold, and this increase was inhibited dose-dependently (0.01-100 micrograms/l) by 12-O-tetradecanoyl phorbol-13-acetate (TPA), a PKC activator.	Tetradecanoylphorbol Acetate	171-208	proopiomelanocortin	Homo sapiens	0-4
7684901-2	1993	(1) The phospholipase A2 blocker p-bromophenacyl bromide (BPB) inhibited the phorbol 12-myristate 13-acetate (PMA)-induced activation of this channel in a concentration-dependent manner (IC50, 4 microM).	Tetradecanoylphorbol Acetate	77-108	phospholipase A2 group IB	Homo sapiens	8-24
7684901-2	1993	(1) The phospholipase A2 blocker p-bromophenacyl bromide (BPB) inhibited the phorbol 12-myristate 13-acetate (PMA)-induced activation of this channel in a concentration-dependent manner (IC50, 4 microM).	Tetradecanoylphorbol Acetate	110-113	phospholipase A2 group IB	Homo sapiens	8-24
8099851-2	1993	Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	171-196	interferon gamma	Homo sapiens	0-16
8099851-2	1993	Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	171-196	interleukin 6	Homo sapiens	37-50
8099851-2	1993	Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	198-201	interferon gamma	Homo sapiens	0-16
8099851-2	1993	Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	198-201	interleukin 6	Homo sapiens	37-50
8500530-0	1993	Induction of CD3 delta epsilon omega by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	40-71	CD3 delta subunit of T-cell receptor complex	Homo sapiens	13-22
8500546-4	1993	Heat shock protein 70 gene was initially down regulated and was induced only after 48 h. The well-differentiated malignant keratinocyte cell line differed in that the c-fos, GADD, SPR1, and IL1-beta genes had several-fold higher induction, but involucrin mRNA was undetectable and fibronectin mRNA was only minimally induced after TPA stimulation.	Tetradecanoylphorbol Acetate	331-334	interleukin 1 beta	Homo sapiens	190-198
8315346-5	1993	Furthermore, under conditions of complete inhibition of PLC by phorbol 12-myristate 13-acetate (PMA), there was no inhibition of PLD, showing that fMLP can activate PLD in the absence of PLC.	Tetradecanoylphorbol Acetate	63-94	formyl peptide receptor 1	Homo sapiens	147-151
8315346-5	1993	Furthermore, under conditions of complete inhibition of PLC by phorbol 12-myristate 13-acetate (PMA), there was no inhibition of PLD, showing that fMLP can activate PLD in the absence of PLC.	Tetradecanoylphorbol Acetate	96-99	formyl peptide receptor 1	Homo sapiens	147-151
8499485-2	1993	Phorbol-12 myristate 13-acetate (PMA) treatment of CMK induced expressions of GPs IIb and IIIa that peaked on the 4th day post-treatment, while treated UT-7 cells showed maximal levels of these GPs during the 6-8th days.	Tetradecanoylphorbol Acetate	0-31	C-X-C motif chemokine ligand 9	Homo sapiens	51-54
8499485-2	1993	Phorbol-12 myristate 13-acetate (PMA) treatment of CMK induced expressions of GPs IIb and IIIa that peaked on the 4th day post-treatment, while treated UT-7 cells showed maximal levels of these GPs during the 6-8th days.	Tetradecanoylphorbol Acetate	33-36	C-X-C motif chemokine ligand 9	Homo sapiens	51-54
8394173-5	1993	Using protein kinase inhibitors, we noticed that while PMA exerted its effect by activating PK-C, IFN gamma operated via activation of calcium/calmodulin-dependent or some other calcium-dependent protein kinases.	Tetradecanoylphorbol Acetate	55-58	proline rich transmembrane protein 2	Homo sapiens	92-96
8394173-5	1993	Using protein kinase inhibitors, we noticed that while PMA exerted its effect by activating PK-C, IFN gamma operated via activation of calcium/calmodulin-dependent or some other calcium-dependent protein kinases.	Tetradecanoylphorbol Acetate	55-58	interferon gamma	Homo sapiens	98-107
8388418-12	1993	The protein kinase C agonist, PMA, did, however, activate ERK-2 in SKW6.4 cells.	Tetradecanoylphorbol Acetate	30-33	mitogen-activated protein kinase 1	Homo sapiens	58-63
8396623-3	1993	ACTH enhanced IGF-II mRNA accumulation dose- and time-dependently, maximally four- to sixfold, and this increase was inhibited dose-dependently (0.01-100 micrograms/l) by 12-O-tetradecanoyl phorbol-13-acetate (TPA), a PKC activator.	Tetradecanoylphorbol Acetate	210-213	proopiomelanocortin	Homo sapiens	0-4
7684371-3	1993	This is mediated via a calcium-dependent pathway, also activated by a phenethyl ester analogue of CCK and calcium ionophores, and by a protein kinase C-dependent cascade, also activated by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	207-243	cholecystokinin	Homo sapiens	98-101
8397329-2	1993	Results showed that PMN in suspension from elderly individuals displayed a phorbol 12-myristate 13-acetate (PMA)-triggered O2- responsiveness which overlapped that seen in the younger counterpart, while a significant decrease of respiratory burst was observed in the presence of formyl-methionyl-leucine-phenylalanine (FMLP).	Tetradecanoylphorbol Acetate	75-106	formyl peptide receptor 1	Homo sapiens	319-323
8397329-2	1993	Results showed that PMN in suspension from elderly individuals displayed a phorbol 12-myristate 13-acetate (PMA)-triggered O2- responsiveness which overlapped that seen in the younger counterpart, while a significant decrease of respiratory burst was observed in the presence of formyl-methionyl-leucine-phenylalanine (FMLP).	Tetradecanoylphorbol Acetate	108-111	formyl peptide receptor 1	Homo sapiens	319-323
8389144-1	1993	Thrombomodulin (TM) antigen and its cofactor activity for thrombin-dependent protein C activation were not detected in the untreated HL-60 human promyelocytic cell line, but appeared in cells cultured with 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3: 10-1,000 nM) or phorbol 12-myristate 13-acetate (PMA: 0.1-10 nM) accompanied by an increase in TM mRNA levels.	Tetradecanoylphorbol Acetate	273-304	coagulation factor II, thrombin	Homo sapiens	58-66
8324074-4	1993	In this study, we examined the effect of cytochalasin B (CB) plus 12-O-tetradecanoylphorbol-13-acetate (TPA) on expression of IL-2 and IL-2R.	Tetradecanoylphorbol Acetate	66-102	interleukin 2	Homo sapiens	126-130
7683925-7	1993	Downregulation of cellular PKC by 18 hours of phorbol myristate acetate (PMA) pretreatment of endothelial cell cultures abolished TNF-mediated extracellular uPA induction.	Tetradecanoylphorbol Acetate	46-71	proline rich transmembrane protein 2	Homo sapiens	27-30
7683925-7	1993	Downregulation of cellular PKC by 18 hours of phorbol myristate acetate (PMA) pretreatment of endothelial cell cultures abolished TNF-mediated extracellular uPA induction.	Tetradecanoylphorbol Acetate	46-71	tumor necrosis factor	Homo sapiens	130-133
7683925-7	1993	Downregulation of cellular PKC by 18 hours of phorbol myristate acetate (PMA) pretreatment of endothelial cell cultures abolished TNF-mediated extracellular uPA induction.	Tetradecanoylphorbol Acetate	46-71	plasminogen activator, urokinase	Homo sapiens	157-160
7683925-7	1993	Downregulation of cellular PKC by 18 hours of phorbol myristate acetate (PMA) pretreatment of endothelial cell cultures abolished TNF-mediated extracellular uPA induction.	Tetradecanoylphorbol Acetate	73-76	proline rich transmembrane protein 2	Homo sapiens	27-30
7683925-7	1993	Downregulation of cellular PKC by 18 hours of phorbol myristate acetate (PMA) pretreatment of endothelial cell cultures abolished TNF-mediated extracellular uPA induction.	Tetradecanoylphorbol Acetate	73-76	tumor necrosis factor	Homo sapiens	130-133
7683925-7	1993	Downregulation of cellular PKC by 18 hours of phorbol myristate acetate (PMA) pretreatment of endothelial cell cultures abolished TNF-mediated extracellular uPA induction.	Tetradecanoylphorbol Acetate	73-76	plasminogen activator, urokinase	Homo sapiens	157-160
7683925-9	1993	Induction of PKC directly with PMA, mezerein, and (-)-octylindolactam V increased endothelial cell levels of extracellular uPA in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	31-34	proline rich transmembrane protein 2	Homo sapiens	13-16
7683925-9	1993	Induction of PKC directly with PMA, mezerein, and (-)-octylindolactam V increased endothelial cell levels of extracellular uPA in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	31-34	plasminogen activator, urokinase	Homo sapiens	123-126
8388385-8	1993	In vivo phosphorylation of KHC and KLCs was demonstrated by immunoprecipitation of [32P]-labeled kinesin from cultured rat hippocampal pyramidal neurons; kinesin phosphorylation was stimulated by 8-chlorophenyl-thio-cAMP or 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	224-260	kinesin family member 5B	Rattus norvegicus	27-30
8503863-5	1993	In experiments in vivo performed on 32P-labelled mesangial cells, the addition of two well-known activators of PKC, namely angiotensin II (AII) and phorbol myristate acetate (PMA), increased preferentially the phosphorylation of annexin I.	Tetradecanoylphorbol Acetate	148-173	annexin A1	Rattus norvegicus	229-238
8503863-5	1993	In experiments in vivo performed on 32P-labelled mesangial cells, the addition of two well-known activators of PKC, namely angiotensin II (AII) and phorbol myristate acetate (PMA), increased preferentially the phosphorylation of annexin I.	Tetradecanoylphorbol Acetate	175-178	annexin A1	Rattus norvegicus	229-238
8324074-4	1993	In this study, we examined the effect of cytochalasin B (CB) plus 12-O-tetradecanoylphorbol-13-acetate (TPA) on expression of IL-2 and IL-2R.	Tetradecanoylphorbol Acetate	104-107	interleukin 2	Homo sapiens	126-130
8481899-3	1993	The human TNF-alpha was about 1000 times more effective than the chemical tumor promoters, okadaic acid and 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	108-144	tumor necrosis factor	Homo sapiens	10-19
8324074-8	1993	In order to determine the percentage of cells that incorporated tritiated thymidine ([3H]dT) in the presence of IL-2 after treatment with CB plus TPA, autoradiography was carried out.	Tetradecanoylphorbol Acetate	146-149	interleukin 2	Homo sapiens	112-116
8389730-0	1993	Contrasting effects of two tumour promoters, phorbol myristate acetate and okadaic acid, on T-cell responses and activation of p42 MAP-kinase/ERK-2.	Tetradecanoylphorbol Acetate	45-70	mitogen-activated protein kinase 1	Homo sapiens	142-147
8485909-2	1993	A strong hybridization signal for the IL-6 probe was observed in mRNA extracted from phytohaemagglutinin (PHA)- and PHA/phorbol myristate acetate (PMA)-stimulated PBMC from most of 12 CVI patients analysed.	Tetradecanoylphorbol Acetate	120-145	interleukin 6	Homo sapiens	38-42
8485909-2	1993	A strong hybridization signal for the IL-6 probe was observed in mRNA extracted from phytohaemagglutinin (PHA)- and PHA/phorbol myristate acetate (PMA)-stimulated PBMC from most of 12 CVI patients analysed.	Tetradecanoylphorbol Acetate	147-150	interleukin 6	Homo sapiens	38-42
8477649-2	1993	To this end, we used 12-O-tetradecanoylphorbol-13-acetate (TPA) as an activator of PKC and a monolayer culture system of immature swine granulosa cells responsive to insulin and lipoprotein under serum-free conditions.	Tetradecanoylphorbol Acetate	59-62	PKC	Sus scrofa	83-86
8477649-10	1993	The results obtained in this in vitro study suggest that the inhibition by TPA at these different sites along the steroidogenic pathway may be similar to that which occurs via hormones that work through the PKC system, such as prostaglandin F2 alpha.	Tetradecanoylphorbol Acetate	75-78	PKC	Sus scrofa	207-210
8349141-1	1993	[Met]-enkephalin or its precursor, pre-[Met]-enkephalin, were exposed to activated oxygen species produced by human phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocytes (PMNs) and then analyzed by high-pressure liquid chromatography (HPLC).	Tetradecanoylphorbol Acetate	116-141	proopiomelanocortin	Homo sapiens	1-16
8349141-1	1993	[Met]-enkephalin or its precursor, pre-[Met]-enkephalin, were exposed to activated oxygen species produced by human phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocytes (PMNs) and then analyzed by high-pressure liquid chromatography (HPLC).	Tetradecanoylphorbol Acetate	143-146	proopiomelanocortin	Homo sapiens	1-16
8349141-1	1993	[Met]-enkephalin or its precursor, pre-[Met]-enkephalin, were exposed to activated oxygen species produced by human phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocytes (PMNs) and then analyzed by high-pressure liquid chromatography (HPLC).	Tetradecanoylphorbol Acetate	143-146	proopiomelanocortin	Homo sapiens	40-55
8349141-5	1993	[Met]-enkephalin, pre-[Met]-enkephalin, and the methionyl-oxidized derivatives suppressed the PMA-induced respiratory burst of PMNs.	Tetradecanoylphorbol Acetate	94-97	proopiomelanocortin	Homo sapiens	1-16
8349141-5	1993	[Met]-enkephalin, pre-[Met]-enkephalin, and the methionyl-oxidized derivatives suppressed the PMA-induced respiratory burst of PMNs.	Tetradecanoylphorbol Acetate	94-97	proopiomelanocortin	Homo sapiens	23-38
8504805-2	1993	Treatment with okadaic acid caused rapid phosphorylation of five proteins with molecular masses of 65, 55, 50, 28 and 15 kDa (p65, p55, p50, p28, p15, respectively) while TPA caused rapid phosphorylation of five proteins with molecular masses of 80, 70, 40, 34 and 28 kDa (p80, p70, p40, p34, p28, respectively).	Tetradecanoylphorbol Acetate	171-174	alpha- and gamma-adaptin binding protein	Mus musculus	288-291
8389730-8	1993	PMA induced a 42,000 MW tyrosine phosphoprotein which co-electrophoresed and co-chromatographed with ERK-2, a p42 MAP-kinase.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 1	Homo sapiens	101-106
7685444-6	1993	After pretreatment with PMA 10(-7) M, the maximum increase in [Ca2+]i induced by AII in hypertensive cells was limited to 108.0 +/- 6.2 nM (p &lt; 0.05 as compared with normotensive cells), whereas the increase in [Ca2+]i in normotensive vSMC remained the same as before: 211.5 +/- 23.4 nM.	Tetradecanoylphorbol Acetate	24-27	angiotensinogen	Rattus norvegicus	81-84
8486772-3	1993	The lymphokine interferon-gamma (IFN) dramatically inhibited the accumulation of apo E in the supernatant of human monocytic THP-1 cells when present during phorbol myristate acetate-induced differentiation.	Tetradecanoylphorbol Acetate	157-182	interferon alpha 1	Homo sapiens	4-37
8486772-3	1993	The lymphokine interferon-gamma (IFN) dramatically inhibited the accumulation of apo E in the supernatant of human monocytic THP-1 cells when present during phorbol myristate acetate-induced differentiation.	Tetradecanoylphorbol Acetate	157-182	apolipoprotein E	Homo sapiens	81-86
8326259-4	1993	PMA, a PKC activator, dose-dependently attenuated the release of prolactin from cultured decidual cells, while a PKC inhibitor, H7, significantly (P &lt; 0.001) diminished the effect of PMA on prolactin release.	Tetradecanoylphorbol Acetate	0-3	prolactin	Homo sapiens	65-74
8326259-4	1993	PMA, a PKC activator, dose-dependently attenuated the release of prolactin from cultured decidual cells, while a PKC inhibitor, H7, significantly (P &lt; 0.001) diminished the effect of PMA on prolactin release.	Tetradecanoylphorbol Acetate	0-3	prolactin	Homo sapiens	193-202
8326259-7	1993	Calcium ionophore A23187, a Ca(2+)-mobilizing agent, also significantly (P &lt; 0.001) attenuated the release of prolactin and potentiated the PMA-induced suppression of prolactin release from decidual cells.	Tetradecanoylphorbol Acetate	143-146	prolactin	Homo sapiens	170-179
7683406-1	1993	CD43, the major sialoglycoprotein of human leukocytes, whose expression is defective in patients with the Wiskott-Aldrich syndrome, was down-regulated by phorbol 12-myristate 13-acetate (PMA) on granulocytes but not on lymphocytes.	Tetradecanoylphorbol Acetate	154-185	sialophorin	Homo sapiens	0-4
7683406-1	1993	CD43, the major sialoglycoprotein of human leukocytes, whose expression is defective in patients with the Wiskott-Aldrich syndrome, was down-regulated by phorbol 12-myristate 13-acetate (PMA) on granulocytes but not on lymphocytes.	Tetradecanoylphorbol Acetate	187-190	sialophorin	Homo sapiens	0-4
7683406-6	1993	Importantly, PMA-induced down-regulation of CD43 on granulocytes was markedly blocked both by the metalloprotease inhibitor 1,10-phenanthroline and by the serine protease inhibitors N alpha-(p-tosyl)-L-lysine chloromethyl ketone and Pefabloc SC, which inhibit two different classes of proteases, thus indicating that the release is proteolytic.	Tetradecanoylphorbol Acetate	13-16	sialophorin	Homo sapiens	44-48
8476858-2	1993	Our results show that differentiation of U937 cells with exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA) induces a temporally delayed (16-24 h) but marked increase in the biosynthesis and secretion of interstitial collagenase and TIMP.	Tetradecanoylphorbol Acetate	69-105	TIMP metallopeptidase inhibitor 1	Homo sapiens	237-241
8476858-2	1993	Our results show that differentiation of U937 cells with exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA) induces a temporally delayed (16-24 h) but marked increase in the biosynthesis and secretion of interstitial collagenase and TIMP.	Tetradecanoylphorbol Acetate	107-110	TIMP metallopeptidase inhibitor 1	Homo sapiens	237-241
8476858-7	1993	However, TPA exposure markedly prolonged the half-life of TIMP mRNA from 4 h to &gt; 20 h. While cycloheximide treatment completely blocked TPA-mediated induction of collagenase mRNA, it only marginally interfered with simultaneously induced TIMP mRNA levels.	Tetradecanoylphorbol Acetate	9-12	TIMP metallopeptidase inhibitor 1	Homo sapiens	58-62
8476858-7	1993	However, TPA exposure markedly prolonged the half-life of TIMP mRNA from 4 h to &gt; 20 h. While cycloheximide treatment completely blocked TPA-mediated induction of collagenase mRNA, it only marginally interfered with simultaneously induced TIMP mRNA levels.	Tetradecanoylphorbol Acetate	9-12	TIMP metallopeptidase inhibitor 1	Homo sapiens	242-246
8476858-7	1993	However, TPA exposure markedly prolonged the half-life of TIMP mRNA from 4 h to &gt; 20 h. While cycloheximide treatment completely blocked TPA-mediated induction of collagenase mRNA, it only marginally interfered with simultaneously induced TIMP mRNA levels.	Tetradecanoylphorbol Acetate	140-143	TIMP metallopeptidase inhibitor 1	Homo sapiens	58-62
8387530-4	1993	Protein kinase C may be involved, since phorbol 12-myristate 13-acetate also induces E-cadherin-mediated aggregation.	Tetradecanoylphorbol Acetate	40-71	cadherin 1	Homo sapiens	85-95
8388009-4	1993	Cultures stimulated with anti-CD3 or with phorbol myristate acetate plus ionophore significantly increased interleukin-4 production, and levels were consistently highest in cells from atopic subjects.	Tetradecanoylphorbol Acetate	42-67	interleukin 4	Homo sapiens	107-120
8473738-5	1993	Similarly, RNA prepared from several B cell lines treated with phorbol myristate acetate (PMA) contained high levels of BL34 mRNA.	Tetradecanoylphorbol Acetate	63-88	regulator of G protein signaling 1	Homo sapiens	120-124
8473738-5	1993	Similarly, RNA prepared from several B cell lines treated with phorbol myristate acetate (PMA) contained high levels of BL34 mRNA.	Tetradecanoylphorbol Acetate	90-93	regulator of G protein signaling 1	Homo sapiens	120-124
8473901-3	1993	Here we show that activation of the cyclic AMP second messenger pathway antagonized the effect of phorbol 12-myristate 13-acetate (PMA) or serum on NGF synthesis, whereas it enhanced that of 1,25(OH)2D3.	Tetradecanoylphorbol Acetate	98-129	nerve growth factor	Homo sapiens	148-151
8473901-3	1993	Here we show that activation of the cyclic AMP second messenger pathway antagonized the effect of phorbol 12-myristate 13-acetate (PMA) or serum on NGF synthesis, whereas it enhanced that of 1,25(OH)2D3.	Tetradecanoylphorbol Acetate	131-134	nerve growth factor	Homo sapiens	148-151
8240934-6	1993	Following incubation with phorbol myristate acetate for 60 min, TNF alpha binding to all cells was decreased.	Tetradecanoylphorbol Acetate	26-51	tumor necrosis factor	Homo sapiens	64-73
7903236-5	1993	After long-term treatment with PMA for 1-5 days, the activities of PKC in cytosolic or membranous fraction almost disappeared, but the tyrosine protein kinase in both subcellular fractions was increased, being most obviously on the third day of culture.	Tetradecanoylphorbol Acetate	31-34	proline rich transmembrane protein 2	Homo sapiens	67-70
8473346-9	1993	Stimulation of the cells with tumor necrosis factor, phorbol 12-myristate 13-acetate, lipopolysaccharide, or interleukin-1 increased mRNA levels for PHS II, and this change correlated well with increased prostacyclin biosynthesis.	Tetradecanoylphorbol Acetate	53-84	prostaglandin-endoperoxide synthase 2	Homo sapiens	149-155
8473351-2	1993	We have established an assay system where overexpression of a specific protein kinase C (PKC) type caused by introduction of the respective cDNA results in the enhancement of a cell response: the transcriptional activation of a set of genes in response to PKC activators such as 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	279-315	protein kinase C alpha	Homo sapiens	89-92
8473351-2	1993	We have established an assay system where overexpression of a specific protein kinase C (PKC) type caused by introduction of the respective cDNA results in the enhancement of a cell response: the transcriptional activation of a set of genes in response to PKC activators such as 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	279-315	protein kinase C alpha	Homo sapiens	256-259
8473351-2	1993	We have established an assay system where overexpression of a specific protein kinase C (PKC) type caused by introduction of the respective cDNA results in the enhancement of a cell response: the transcriptional activation of a set of genes in response to PKC activators such as 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	317-320	protein kinase C alpha	Homo sapiens	89-92
8473351-2	1993	We have established an assay system where overexpression of a specific protein kinase C (PKC) type caused by introduction of the respective cDNA results in the enhancement of a cell response: the transcriptional activation of a set of genes in response to PKC activators such as 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	317-320	protein kinase C alpha	Homo sapiens	256-259
8476858-7	1993	However, TPA exposure markedly prolonged the half-life of TIMP mRNA from 4 h to &gt; 20 h. While cycloheximide treatment completely blocked TPA-mediated induction of collagenase mRNA, it only marginally interfered with simultaneously induced TIMP mRNA levels.	Tetradecanoylphorbol Acetate	140-143	TIMP metallopeptidase inhibitor 1	Homo sapiens	242-246
8507443-4	1993	This same TPA response element appears to be responsible for induction of hANP gene promoter activity by the phorbol ester TPA.	Tetradecanoylphorbol Acetate	10-13	natriuretic peptide A	Homo sapiens	74-78
8385998-2	1993	Treatment of platelets with 200 nM 12-O-tetradecanoylphorbol-13-acetate (PMA) led to 5-fold stimulations of cytosolic MBP and S6 peptide kinase activities within 1 min.	Tetradecanoylphorbol Acetate	35-71	myelin basic protein	Ovis aries	118-121
8385998-2	1993	Treatment of platelets with 200 nM 12-O-tetradecanoylphorbol-13-acetate (PMA) led to 5-fold stimulations of cytosolic MBP and S6 peptide kinase activities within 1 min.	Tetradecanoylphorbol Acetate	73-76	myelin basic protein	Ovis aries	118-121
8385998-3	1993	Immunoblotting analysis of phenyl-Superose-fractionated cytosol from PMA-treated platelets with a panel of mitogen-activated protein (MAP) kinase anti-peptide antibodies revealed that one of the activated MBP kinases was p42mapk.	Tetradecanoylphorbol Acetate	69-72	myelin basic protein	Ovis aries	205-208
8507443-4	1993	This same TPA response element appears to be responsible for induction of hANP gene promoter activity by the phorbol ester TPA.	Tetradecanoylphorbol Acetate	123-126	natriuretic peptide A	Homo sapiens	74-78
8386622-1	1993	In many different cell types treatment with phorbol esters (e.g. 4 beta-phorbol 12-myristate 13-acetate, PMA) leads to the activation of protein-kinase C (PKC) and subsequently to the activation of the activator-protein-1(AP-1)-responsive gene expression.	Tetradecanoylphorbol Acetate	67-103	proline rich transmembrane protein 2	Homo sapiens	137-153
8461467-5	1993	The higher p24 production was obtained when B cells were preactivated for 2 days by phorbol 12-myristate 13-acetate (PMA) before infection and then cultured in the presence of low-molecular weight B-cell growth factor (LMW-BCGF).	Tetradecanoylphorbol Acetate	84-115	transmembrane p24 trafficking protein 2	Homo sapiens	11-14
8461467-5	1993	The higher p24 production was obtained when B cells were preactivated for 2 days by phorbol 12-myristate 13-acetate (PMA) before infection and then cultured in the presence of low-molecular weight B-cell growth factor (LMW-BCGF).	Tetradecanoylphorbol Acetate	117-120	transmembrane p24 trafficking protein 2	Homo sapiens	11-14
8386622-1	1993	In many different cell types treatment with phorbol esters (e.g. 4 beta-phorbol 12-myristate 13-acetate, PMA) leads to the activation of protein-kinase C (PKC) and subsequently to the activation of the activator-protein-1(AP-1)-responsive gene expression.	Tetradecanoylphorbol Acetate	67-103	proline rich transmembrane protein 2	Homo sapiens	155-158
8386622-1	1993	In many different cell types treatment with phorbol esters (e.g. 4 beta-phorbol 12-myristate 13-acetate, PMA) leads to the activation of protein-kinase C (PKC) and subsequently to the activation of the activator-protein-1(AP-1)-responsive gene expression.	Tetradecanoylphorbol Acetate	105-108	proline rich transmembrane protein 2	Homo sapiens	137-153
8386622-1	1993	In many different cell types treatment with phorbol esters (e.g. 4 beta-phorbol 12-myristate 13-acetate, PMA) leads to the activation of protein-kinase C (PKC) and subsequently to the activation of the activator-protein-1(AP-1)-responsive gene expression.	Tetradecanoylphorbol Acetate	105-108	proline rich transmembrane protein 2	Homo sapiens	155-158
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	Tetradecanoylphorbol Acetate	156-159	cathelicidin antimicrobial peptide	Homo sapiens	56-60
8462462-3	1993	Follistatin mRNA was quantitated by slot blot hybridization of total RNA from primary cultures of porcine granulosa cells treated with the phorbol ester phorbol 12-myristate 13-acetate (PMA), an activator of PKC.	Tetradecanoylphorbol Acetate	153-184	proline rich transmembrane protein 2	Homo sapiens	208-211
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	Tetradecanoylphorbol Acetate	156-159	cathelicidin antimicrobial peptide	Homo sapiens	72-76
8462478-1	1993	We and others have previously shown that 12-O-tetracanoylphorbol-13-acetate (TPA), a protein kinase-C (PKC) activator, inhibits TSH-stimulated iodide organification in porcine thyroid cells.	Tetradecanoylphorbol Acetate	77-80	proline rich transmembrane protein 2	Homo sapiens	85-101
8462478-1	1993	We and others have previously shown that 12-O-tetracanoylphorbol-13-acetate (TPA), a protein kinase-C (PKC) activator, inhibits TSH-stimulated iodide organification in porcine thyroid cells.	Tetradecanoylphorbol Acetate	77-80	proline rich transmembrane protein 2	Homo sapiens	103-106
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	Tetradecanoylphorbol Acetate	156-159	cathelicidin antimicrobial peptide	Homo sapiens	72-76
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	Tetradecanoylphorbol Acetate	156-159	interleukin 1 beta	Homo sapiens	168-186
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	Tetradecanoylphorbol Acetate	156-159	interleukin 1 beta	Homo sapiens	187-196
8386622-2	1993	We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60).	Tetradecanoylphorbol Acetate	156-159	GLI family zinc finger 2	Homo sapiens	247-252
8314909-2	1993	12-o-tetradecanoyl 13-phorbol acetate (TPA) differentiated them to macrophage-like cells with induction of MMP-9, and tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) stimulated the production of MMP-9 by TPA-treated cells.	Tetradecanoylphorbol Acetate	39-42	tumor necrosis factor	Homo sapiens	118-145
8384561-2	1993	As detected by reverse transcriptase-polymerase chain reaction, IL-2 mRNA was expressed only after stimulation with the combination of phorbol 12-myristate 13-acetate (PMA) plus ionomycin.	Tetradecanoylphorbol Acetate	135-166	interleukin 2	Homo sapiens	64-68
8384561-2	1993	As detected by reverse transcriptase-polymerase chain reaction, IL-2 mRNA was expressed only after stimulation with the combination of phorbol 12-myristate 13-acetate (PMA) plus ionomycin.	Tetradecanoylphorbol Acetate	168-171	interleukin 2	Homo sapiens	64-68
8098319-9	1993	Pretreatment of the neutrophils with anti-CD11/CD18 antibodies prevented the increase in PMA-stimulated adherence.	Tetradecanoylphorbol Acetate	89-92	integrin subunit beta 2	Homo sapiens	47-51
8098319-10	1993	We conclude that PMA-stimulated adherence to airway epithelial cells is in part dependent on the neutrophil CD11/CD18 adherence complex.	Tetradecanoylphorbol Acetate	17-20	integrin subunit beta 2	Homo sapiens	113-117
8314909-3	1993	TNF alpha also induced the production of MMP-9 by TPA-untreated U937 cells without morphological differentiation.	Tetradecanoylphorbol Acetate	50-53	tumor necrosis factor	Homo sapiens	0-9
7681399-2	1993	Treatment of these cells with human recombinant human tumor necrosis factor (TNF) resulted in an increase in phagocytosis and phorbol myristate acetate-stimulated superoxide anion production at 12 h and growth retardation occurring at 24 h. Moreover, TNF induced a moderate increase of CD14 surface antigen expression, used as a phenotypic marker of monocyte/macrophage differentiation.	Tetradecanoylphorbol Acetate	126-151	tumor necrosis factor	Homo sapiens	54-75
7681399-2	1993	Treatment of these cells with human recombinant human tumor necrosis factor (TNF) resulted in an increase in phagocytosis and phorbol myristate acetate-stimulated superoxide anion production at 12 h and growth retardation occurring at 24 h. Moreover, TNF induced a moderate increase of CD14 surface antigen expression, used as a phenotypic marker of monocyte/macrophage differentiation.	Tetradecanoylphorbol Acetate	126-151	tumor necrosis factor	Homo sapiens	77-80
7681399-2	1993	Treatment of these cells with human recombinant human tumor necrosis factor (TNF) resulted in an increase in phagocytosis and phorbol myristate acetate-stimulated superoxide anion production at 12 h and growth retardation occurring at 24 h. Moreover, TNF induced a moderate increase of CD14 surface antigen expression, used as a phenotypic marker of monocyte/macrophage differentiation.	Tetradecanoylphorbol Acetate	126-151	tumor necrosis factor	Homo sapiens	251-254
8494827-4	1993	Here we show that protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) causes a decrease of both CD4 and CD8 expression at the cell surface level and at the mRNA level in a CD4+ CD8+ T cell line and in freshly isolated thymocytes.	Tetradecanoylphorbol Acetate	55-86	CD4 molecule	Homo sapiens	119-122
8494827-4	1993	Here we show that protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) causes a decrease of both CD4 and CD8 expression at the cell surface level and at the mRNA level in a CD4+ CD8+ T cell line and in freshly isolated thymocytes.	Tetradecanoylphorbol Acetate	55-86	CD4 molecule	Homo sapiens	195-198
8494827-4	1993	Here we show that protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) causes a decrease of both CD4 and CD8 expression at the cell surface level and at the mRNA level in a CD4+ CD8+ T cell line and in freshly isolated thymocytes.	Tetradecanoylphorbol Acetate	88-91	CD4 molecule	Homo sapiens	119-122
8494827-4	1993	Here we show that protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) causes a decrease of both CD4 and CD8 expression at the cell surface level and at the mRNA level in a CD4+ CD8+ T cell line and in freshly isolated thymocytes.	Tetradecanoylphorbol Acetate	88-91	CD4 molecule	Homo sapiens	195-198
8314909-2	1993	12-o-tetradecanoyl 13-phorbol acetate (TPA) differentiated them to macrophage-like cells with induction of MMP-9, and tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) stimulated the production of MMP-9 by TPA-treated cells.	Tetradecanoylphorbol Acetate	39-42	tumor necrosis factor	Homo sapiens	147-156
8455941-5	1993	Moreover, whereas both Tax and phorbol 12-myristate 13-acetate (PMA) are able to efficiently induce the binding of NF-kappa B to the IL-2R alpha kappa B site, PMA is functionally inactive.	Tetradecanoylphorbol Acetate	31-62	nuclear factor kappa B subunit 1	Homo sapiens	115-125
8388998-1	1993	Interaction between protein kinase C (PKC)- and glucocorticoid receptor (GR)-mediated signaling is suggested by the ability of the PKC activating phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to inhibit GR-dependent transcription of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR).	Tetradecanoylphorbol Acetate	160-196	nuclear receptor subfamily 3 group C member 1	Homo sapiens	48-71
8388998-1	1993	Interaction between protein kinase C (PKC)- and glucocorticoid receptor (GR)-mediated signaling is suggested by the ability of the PKC activating phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to inhibit GR-dependent transcription of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR).	Tetradecanoylphorbol Acetate	198-201	nuclear receptor subfamily 3 group C member 1	Homo sapiens	48-71
8391491-5	1993	Whereas induction by epidermal growth factor (EGF) was abolished by cycloheximide and puromycin, increases in PRL mRNA caused by thyrotropin releasing hormone, 12-O-tetradecanoylphorbol 13-acetate, forskolin, or dibutyryl cyclic AMP were unaffected.	Tetradecanoylphorbol Acetate	160-196	prolactin	Rattus norvegicus	110-113
8455941-5	1993	Moreover, whereas both Tax and phorbol 12-myristate 13-acetate (PMA) are able to efficiently induce the binding of NF-kappa B to the IL-2R alpha kappa B site, PMA is functionally inactive.	Tetradecanoylphorbol Acetate	64-67	nuclear factor kappa B subunit 1	Homo sapiens	115-125
8390902-5	1993	The nuclear induction of the Ah receptor by TCDD can be inhibited by phorbol esters such as TPA (Okino et al., 1992), but analysis of nuclear TI-1 and TI-2 shows that TPA can selectively inhibit the appearance of TI-1.	Tetradecanoylphorbol Acetate	92-95	aryl-hydrocarbon receptor	Mus musculus	29-40
8390902-5	1993	The nuclear induction of the Ah receptor by TCDD can be inhibited by phorbol esters such as TPA (Okino et al., 1992), but analysis of nuclear TI-1 and TI-2 shows that TPA can selectively inhibit the appearance of TI-1.	Tetradecanoylphorbol Acetate	167-170	aryl-hydrocarbon receptor	Mus musculus	29-40
8097058-4	1993	This paper shows that IL-4 alone was able to induce aggregation of B-CLL cells and to strongly enhance TPA+BSF-MP6-induced aggregation.	Tetradecanoylphorbol Acetate	103-106	interleukin 4	Homo sapiens	22-26
8449955-9	1993	Treatment of intact astrocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA), which stimulates protein kinase C (PKC), increased the phosphorylation of the more acidic spot (Pb) while decreasing Pa intensity.	Tetradecanoylphorbol Acetate	36-72	proline rich transmembrane protein 2	Homo sapiens	97-113
8461005-3	1993	Both TPA and bryostatin 1 at 10 nM induced a rapid increase in membrane-associated PKC-alpha immunoreactivity which was sustained for 72 hours in TPA-treated cells, but was down-regulated within 24 hours in bryostatin-treated cells.	Tetradecanoylphorbol Acetate	5-8	protein kinase C alpha	Homo sapiens	83-92
8461005-3	1993	Both TPA and bryostatin 1 at 10 nM induced a rapid increase in membrane-associated PKC-alpha immunoreactivity which was sustained for 72 hours in TPA-treated cells, but was down-regulated within 24 hours in bryostatin-treated cells.	Tetradecanoylphorbol Acetate	146-149	protein kinase C alpha	Homo sapiens	83-92
8461005-4	1993	TPA likewise induced a sustained phosphorylation of an 80 kDa PKC substrate whereas in bryostatin-treated cells the 80 kDa substrate was rapidly phosphorylated reaching a maximum at 6 hours followed by a decline to basal level within 48 hours.	Tetradecanoylphorbol Acetate	0-3	protein kinase C alpha	Homo sapiens	62-65
8461005-5	1993	A higher concentration of TPA (300 nM), which results in a less differentiated phenotype, induced down-regulation of PKC-alpha within 24 hours.	Tetradecanoylphorbol Acetate	26-29	protein kinase C alpha	Homo sapiens	117-126
8461005-7	1993	These results suggest that the divergent actions of bryostatin 1 and TPA in SH-SY5Y cells are at least partially due to differential modulation of PKC-alpha but not PKC-epsilon by these two agents.	Tetradecanoylphorbol Acetate	69-72	protein kinase C alpha	Homo sapiens	147-156
8384125-3	1993	Protein kinase C (PKC) is known to couple membrane activity to AChR gene inactivation; myogenin gene transcription was also rapidly blocked by the PKC activator PMA, whereas electrostimulation remained without effect on myogenin gene activity in muscle that was either exposed to the kinase inhibitor staurosporine or chronically treated with PMA to deplete PKC.	Tetradecanoylphorbol Acetate	161-164	cholinergic receptor nicotinic delta subunit	Gallus gallus	63-67
8460491-2	1993	Both infected cells (THP-1/HIV-1IIIB) growing in suspension and uninfected, phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells, which are adherent, showed ultrastructural characteristics of differentiated cells.	Tetradecanoylphorbol Acetate	76-107	GLI family zinc finger 2	Homo sapiens	122-127
8460491-2	1993	Both infected cells (THP-1/HIV-1IIIB) growing in suspension and uninfected, phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells, which are adherent, showed ultrastructural characteristics of differentiated cells.	Tetradecanoylphorbol Acetate	109-112	GLI family zinc finger 2	Homo sapiens	122-127
8449916-1	1993	The tumor promoter phorbol myristate acetate (PMA) directly activates protein kinase C (PKC) and, in human platelets, induces aggregation, release of granular contents, mobilization of intracellular Ca2+ as detected by the photoprotein aequorin, and phosphorylation of the 47-kDa substrate (p47) of PKC.	Tetradecanoylphorbol Acetate	19-44	proline rich transmembrane protein 2	Homo sapiens	70-86
8449916-1	1993	The tumor promoter phorbol myristate acetate (PMA) directly activates protein kinase C (PKC) and, in human platelets, induces aggregation, release of granular contents, mobilization of intracellular Ca2+ as detected by the photoprotein aequorin, and phosphorylation of the 47-kDa substrate (p47) of PKC.	Tetradecanoylphorbol Acetate	19-44	proline rich transmembrane protein 2	Homo sapiens	88-91
8449916-1	1993	The tumor promoter phorbol myristate acetate (PMA) directly activates protein kinase C (PKC) and, in human platelets, induces aggregation, release of granular contents, mobilization of intracellular Ca2+ as detected by the photoprotein aequorin, and phosphorylation of the 47-kDa substrate (p47) of PKC.	Tetradecanoylphorbol Acetate	19-44	proline rich transmembrane protein 2	Homo sapiens	299-302
8449916-1	1993	The tumor promoter phorbol myristate acetate (PMA) directly activates protein kinase C (PKC) and, in human platelets, induces aggregation, release of granular contents, mobilization of intracellular Ca2+ as detected by the photoprotein aequorin, and phosphorylation of the 47-kDa substrate (p47) of PKC.	Tetradecanoylphorbol Acetate	46-49	proline rich transmembrane protein 2	Homo sapiens	70-86
8449916-1	1993	The tumor promoter phorbol myristate acetate (PMA) directly activates protein kinase C (PKC) and, in human platelets, induces aggregation, release of granular contents, mobilization of intracellular Ca2+ as detected by the photoprotein aequorin, and phosphorylation of the 47-kDa substrate (p47) of PKC.	Tetradecanoylphorbol Acetate	46-49	proline rich transmembrane protein 2	Homo sapiens	88-91
8449916-1	1993	The tumor promoter phorbol myristate acetate (PMA) directly activates protein kinase C (PKC) and, in human platelets, induces aggregation, release of granular contents, mobilization of intracellular Ca2+ as detected by the photoprotein aequorin, and phosphorylation of the 47-kDa substrate (p47) of PKC.	Tetradecanoylphorbol Acetate	46-49	proline rich transmembrane protein 2	Homo sapiens	299-302
8449916-2	1993	Whether PKC activation by PMA or other agonists requires translocation of PKC from the cytoplasm to the lipids of the platelet surface membrane, however, is not known.	Tetradecanoylphorbol Acetate	26-29	proline rich transmembrane protein 2	Homo sapiens	8-11
8454038-1	1993	The role of protein tyrosine kinases in the expression of interleukin-1 beta (IL-1 beta) gene in response to phorbol esters (PMA) in THP-1 cell line was investigated.	Tetradecanoylphorbol Acetate	125-128	interleukin 1 beta	Homo sapiens	58-76
8454038-1	1993	The role of protein tyrosine kinases in the expression of interleukin-1 beta (IL-1 beta) gene in response to phorbol esters (PMA) in THP-1 cell line was investigated.	Tetradecanoylphorbol Acetate	125-128	interleukin 1 beta	Homo sapiens	78-87
8449916-2	1993	Whether PKC activation by PMA or other agonists requires translocation of PKC from the cytoplasm to the lipids of the platelet surface membrane, however, is not known.	Tetradecanoylphorbol Acetate	26-29	proline rich transmembrane protein 2	Homo sapiens	74-77
8449955-9	1993	Treatment of intact astrocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA), which stimulates protein kinase C (PKC), increased the phosphorylation of the more acidic spot (Pb) while decreasing Pa intensity.	Tetradecanoylphorbol Acetate	36-72	proline rich transmembrane protein 2	Homo sapiens	115-118
8449916-4	1993	Neither alpha-, beta-, delta-, or zeta-PKC isozymes translocated to the plasma membrane following bryostatin-1, although translocation of both alpha- and beta-PKC isozymes was seen in PMA-stimulated platelets.	Tetradecanoylphorbol Acetate	184-187	proline rich transmembrane protein 2	Homo sapiens	159-162
8454058-1	1993	Phorbol esters such as phorbol 12-myristate,13-acetate (PMA) are potent activators of protein kinase C (PKC), and activate all PKC isozymes except zeta and lambda.	Tetradecanoylphorbol Acetate	56-59	protein kinase C alpha	Homo sapiens	104-107
8454058-1	1993	Phorbol esters such as phorbol 12-myristate,13-acetate (PMA) are potent activators of protein kinase C (PKC), and activate all PKC isozymes except zeta and lambda.	Tetradecanoylphorbol Acetate	56-59	protein kinase C alpha	Homo sapiens	127-130
8449955-9	1993	Treatment of intact astrocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA), which stimulates protein kinase C (PKC), increased the phosphorylation of the more acidic spot (Pb) while decreasing Pa intensity.	Tetradecanoylphorbol Acetate	74-77	proline rich transmembrane protein 2	Homo sapiens	97-113
8449955-9	1993	Treatment of intact astrocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA), which stimulates protein kinase C (PKC), increased the phosphorylation of the more acidic spot (Pb) while decreasing Pa intensity.	Tetradecanoylphorbol Acetate	74-77	proline rich transmembrane protein 2	Homo sapiens	115-118
8460169-3	1993	It is demonstrated here with human T lymphocytes and monocytes that different stimuli, including tumor necrosis factor alpha and phorbol 12-myristate 13-acetate, cause rapid degradation of I kappa B-alpha, with concomitant activation of NF-kappa B, followed by a dramatic increase in I kappa B-alpha mRNA and protein synthesis.	Tetradecanoylphorbol Acetate	129-160	NFKB inhibitor alpha	Homo sapiens	189-204
8460169-3	1993	It is demonstrated here with human T lymphocytes and monocytes that different stimuli, including tumor necrosis factor alpha and phorbol 12-myristate 13-acetate, cause rapid degradation of I kappa B-alpha, with concomitant activation of NF-kappa B, followed by a dramatic increase in I kappa B-alpha mRNA and protein synthesis.	Tetradecanoylphorbol Acetate	129-160	nuclear factor kappa B subunit 1	Homo sapiens	237-247
8460169-3	1993	It is demonstrated here with human T lymphocytes and monocytes that different stimuli, including tumor necrosis factor alpha and phorbol 12-myristate 13-acetate, cause rapid degradation of I kappa B-alpha, with concomitant activation of NF-kappa B, followed by a dramatic increase in I kappa B-alpha mRNA and protein synthesis.	Tetradecanoylphorbol Acetate	129-160	NFKB inhibitor alpha	Homo sapiens	284-299
8444879-0	1993	Human T cell leukemia virus type I Tax and phorbol 12-myristate 13-acetate induce expression of the A20 zinc finger protein by distinct mechanisms involving nuclear factor kappa B.	Tetradecanoylphorbol Acetate	43-74	nuclear factor kappa B subunit 1	Homo sapiens	157-179
8444883-5	1993	On the other hand, PMA and thrombin induced translocation of all four isoenzymes of PKC.	Tetradecanoylphorbol Acetate	19-22	protein kinase C alpha	Homo sapiens	84-87
8444885-4	1993	TPA induction inhibits the binding of the lineage limited transcription factor NF-E2 to this transcriptional control element.	Tetradecanoylphorbol Acetate	0-3	nuclear factor, erythroid 2	Homo sapiens	79-84
7680573-7	1993	The effect of TPA on the activity of the calmodulin-sensitive adenylyl cyclases was not mediated through increases in intracellular free calcium.	Tetradecanoylphorbol Acetate	14-17	calmodulin 1	Homo sapiens	41-51
8444885-8	1993	The divergent effects of hemin and TPA on gene expression in K562 cells are mediated, in part, by their contrasting effects on the transcription factor NF-E2.	Tetradecanoylphorbol Acetate	35-38	nuclear factor, erythroid 2	Homo sapiens	152-157
8443382-0	1993	Downregulation of GATA-1 expression during phorbol myristate acetate-induced megakaryocytic differentiation of human erythroleukemia cells.	Tetradecanoylphorbol Acetate	43-68	GATA binding protein 1	Homo sapiens	18-24
8382972-1	1993	The effects of monocytic/macrophage and granulocytic differentiation induced by phorbol myristate acetate (TPA) and all-trans retinoic acid, respectively, were tested on the induction of apoptosis in human promyelocytic leukemia HL-60 cells treated with topoisomerase I and II inhibitors.	Tetradecanoylphorbol Acetate	80-105	plasminogen activator, tissue type	Homo sapiens	107-110
8384819-2	1993	Doxycycline also efficiently inhibited phorbol myristate acetate-triggered neutrophil-mediated degradation of alpha-1-antitrypsin.	Tetradecanoylphorbol Acetate	39-64	serpin family A member 1	Homo sapiens	110-129
8383965-1	1993	Incubation of human polymorphonuclear leucocytes (PMN) with either the chemotactic factor N-formylmethionyl-leucylphenylalanine (FMLP) or phorbol 12-myristate 13-acetate (PMA) activates a kinase with phosphorylating activity towards a known microtubule-associated protein-2 (MAP) kinase substrate, the epidermal growth factor receptor peptide (T669).	Tetradecanoylphorbol Acetate	138-169	epidermal growth factor receptor	Homo sapiens	302-334
8443382-3	1993	Studies of the molecular mechanism of PMA-induced differentiation in HEL cells showed that when HEL cells are treated with PMA, they dramatically decrease the expression of the erythroid-specific gene glycophorin A at the mRNA level but apparently not at the steady-state protein level.	Tetradecanoylphorbol Acetate	38-41	glycophorin A (MNS blood group)	Homo sapiens	201-214
8453712-8	1993	Treatment of mice promoted with 0.1 microgram of TPA with IFN-gamma (&gt; or = 2500 units) significantly increased the skin"s vascular permeability.	Tetradecanoylphorbol Acetate	49-52	interferon gamma	Mus musculus	58-67
8453712-10	1993	Treatment of TPA-promoted mice with IFN-gamma, and to a lesser extent IFN-beta, weakly potentiated the TPA-dependent induction of epidermal ODC activity.	Tetradecanoylphorbol Acetate	13-16	interferon gamma	Mus musculus	36-45
8453712-10	1993	Treatment of TPA-promoted mice with IFN-gamma, and to a lesser extent IFN-beta, weakly potentiated the TPA-dependent induction of epidermal ODC activity.	Tetradecanoylphorbol Acetate	103-106	interferon gamma	Mus musculus	36-45
8453997-3	1993	Since phorbol 12-myristate 13-acetate, which directly binds and activates protein kinase C (PKC), induced cox expression, we examined the role of PKC as an intracellular mediator of IL-1 activity in human endothelial cells.	Tetradecanoylphorbol Acetate	6-37	protein kinase C alpha	Homo sapiens	92-95
7679999-2	1993	The addition of phorbol 12-myristate 13-acetate (PMA) to Hep 3B cells subsequently grown under hypoxic conditions resulted in a dose-dependent inhibition of hypoxia-induced Epo production by as much as 95 +/- 1% with half-maximal inhibition at 8 ng/mL.	Tetradecanoylphorbol Acetate	16-47	erythropoietin	Homo sapiens	173-176
7679999-2	1993	The addition of phorbol 12-myristate 13-acetate (PMA) to Hep 3B cells subsequently grown under hypoxic conditions resulted in a dose-dependent inhibition of hypoxia-induced Epo production by as much as 95 +/- 1% with half-maximal inhibition at 8 ng/mL.	Tetradecanoylphorbol Acetate	49-52	erythropoietin	Homo sapiens	173-176
7679999-3	1993	By Northern blot analysis, Epo mRNA levels were correspondingly decreased after treatment with PMA.	Tetradecanoylphorbol Acetate	95-98	erythropoietin	Homo sapiens	27-30
7679999-6	1993	The PMA-induced inhibition of hypoxia-induced Epo production was shown to occur as early as 3 hours after PMA addition, suggesting that the initial activation, rather than the subsequent decrease in protein kinase C activity, is of primary importance.	Tetradecanoylphorbol Acetate	4-7	erythropoietin	Homo sapiens	46-49
7679999-6	1993	The PMA-induced inhibition of hypoxia-induced Epo production was shown to occur as early as 3 hours after PMA addition, suggesting that the initial activation, rather than the subsequent decrease in protein kinase C activity, is of primary importance.	Tetradecanoylphorbol Acetate	106-109	erythropoietin	Homo sapiens	46-49
8453990-5	1993	The expression of both PA and PAI activity in the rabbit ligament fibroblasts increased upon addition of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	105-130	plasminogen activator inhibitor 1	Oryctolagus cuniculus	30-33
7679999-7	1993	The relative specificity of the PMA-induced inhibition of Epo production was demonstrated by 1) the finding that overall protein and RNA synthesis were not similarly decreased as measured by 3H-leucine and 3H-uridine pulse labeling studies and 2) the observation that the biologically inactive phorbol ester, 4 alpha-phorbol didecanoate, failed to have any effect on hypoxia-induced Epo production.	Tetradecanoylphorbol Acetate	32-35	erythropoietin	Homo sapiens	58-61
8453990-5	1993	The expression of both PA and PAI activity in the rabbit ligament fibroblasts increased upon addition of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	132-135	plasminogen activator inhibitor 1	Oryctolagus cuniculus	30-33
8441379-7	1993	When ligated to the murine c-fos promoter, however, the proIL-1 beta enhancer was inducible in phorbol myristate acetate-stimulated HeLa cells, suggesting the existence of a proIL-1 beta promoter-proximal requirement for tissue specificity.	Tetradecanoylphorbol Acetate	95-120	interleukin 1 beta	Homo sapiens	56-68
8436909-5	1993	PMA-treated, but not untreated cells, displayed an additional peptide derived from interleukin 1 beta.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Homo sapiens	83-101
8436914-4	1993	There was no induction of nuclear NF-kappa B in B-1 cells stimulated by sIgM crosslinking, although NF-kappa B was stimulated by phorbol myristate acetate and by LPS.	Tetradecanoylphorbol Acetate	129-154	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	100-110
8384238-3	1993	Following pretreatment of human PMNs with recombinant IFN-gamma, superoxide anion release was selectively primed toward the receptor-initiated stimulants f-Met-Leu-Phe (fMLP) and C5a but not toward the transduction-mediated stimulants phorbol myristate acetate and A23187, a calcium ionophore.	Tetradecanoylphorbol Acetate	235-260	interferon gamma	Homo sapiens	54-63
8387158-0	1993	Regulation of 3 beta-hydroxysteroid dehydrogenase and 17 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels by cyclic adenosine 3",5"-monophosphate and phorbol myristate acetate in human choriocarcinoma cells.	Tetradecanoylphorbol Acetate	169-194	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	54-90
8387158-8	1993	When JEG-3 cells were exposed to 8CPTcAMP or PMA, 3 beta HSD-I and 17 beta HSD-II gene transcriptions were increased in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	45-48	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	67-78
8387158-9	1993	Moreover, the combined effects of PMA and 8CPTcAMP on 3 beta HSD-I mRNA levels was additive and synergistic on 17 beta HSD-II mRNA levels.	Tetradecanoylphorbol Acetate	34-37	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	111-122
7679999-7	1993	The relative specificity of the PMA-induced inhibition of Epo production was demonstrated by 1) the finding that overall protein and RNA synthesis were not similarly decreased as measured by 3H-leucine and 3H-uridine pulse labeling studies and 2) the observation that the biologically inactive phorbol ester, 4 alpha-phorbol didecanoate, failed to have any effect on hypoxia-induced Epo production.	Tetradecanoylphorbol Acetate	32-35	erythropoietin	Homo sapiens	383-386
7680355-7	1993	After treatment with phorbol 12-myristate 13-acetate (10(-7) M) for 7 days, there was an increase in the mRNA for CgB and SgII mRNAs in GH and null cell tumors, while dexamethasone treatment for 7 days increased CgA mRNA in GH and null cell adenomas.	Tetradecanoylphorbol Acetate	21-52	chromogranin A	Homo sapiens	212-215
8436606-1	1993	The current study shows that a clonal derivative of the Jurkat cell line up-regulates both the avidity and density of the alpha 6/beta 1 receptor in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	161-192	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	130-136
8436606-1	1993	The current study shows that a clonal derivative of the Jurkat cell line up-regulates both the avidity and density of the alpha 6/beta 1 receptor in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	194-197	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	130-136
8436606-7	1993	The second phase peaks after 48-72 hours of treatment with PMA, is sensitive to cycloheximide, can be blocked by Mabs to the beta 1 and alpha 6 subunits, and is associated with increased expression of the alpha 6 epitope.	Tetradecanoylphorbol Acetate	59-62	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	125-143
8436813-5	1993	PKC alpha and beta existed primarily in the cytosol, translocated to the membrane fraction after 10 minutes of treatment with PMA, and almost completely disappeared within 16 h. A larger fraction of PKC delta and epsilon existed in the membrane fraction compared to PKC alpha or beta, and PKC epsilon translocated to the membrane fraction rapidly.	Tetradecanoylphorbol Acetate	126-129	protein kinase C alpha	Homo sapiens	0-9
8436813-11	1993	Similar PMA-induced translocation responses were observed in murine thymocytes showing that the responses are not unique to PKC isoforms in Jurkat.	Tetradecanoylphorbol Acetate	8-11	proline rich transmembrane protein 2	Homo sapiens	124-127
8441379-7	1993	When ligated to the murine c-fos promoter, however, the proIL-1 beta enhancer was inducible in phorbol myristate acetate-stimulated HeLa cells, suggesting the existence of a proIL-1 beta promoter-proximal requirement for tissue specificity.	Tetradecanoylphorbol Acetate	95-120	interleukin 1 beta	Homo sapiens	174-186
8382693-5	1993	Treatment of these cells with phytohemagglutinin and 12-O-tetradecanoylphorbol-13-acetate in the presence of fetal calf serum resulted in rapid induction of cyclin D2 RNA in early G1 and slower induction of cyclin D3 in late G1.	Tetradecanoylphorbol Acetate	53-89	cyclin D2	Homo sapiens	157-166
8472873-8	1993	Co-treatment with forskolin and TPA resulted in a 6.4-fold induction in its promoter activity, suggesting that two distinct signal transduction pathways, the cAMP-dependent protein kinase-A pathway and diacylglycerol-dependent protein kinase-C pathway, act coordinately to modulate follistatin gene transcription.	Tetradecanoylphorbol Acetate	32-35	follistatin	Rattus norvegicus	282-293
8483478-0	1993	Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	124-155	early growth response 1	Rattus norvegicus	45-50
8483478-8	1993	We have also established that the regulatory region of NGFIA that mediates NGF induction also mediates the induction by serum and phorbol 12-myristate 13-acetate, suggesting that multiple signal transduction pathways must converge on these sequences to regulate the expression of this gene.	Tetradecanoylphorbol Acetate	130-161	early growth response 1	Rattus norvegicus	55-60
8437865-0	1993	Ha-Ras functions downstream from protein kinase C in v-Fps-induced gene expression mediated by TPA response elements.	Tetradecanoylphorbol Acetate	95-98	proline rich transmembrane protein 2	Homo sapiens	33-49
7686304-7	1993	Chloride efflux from colon cancer cells is stimulated by cyclic AMP and vaso-active intestinal peptide (VIP), and can be inhibited by pretreatment of the cells with phorbol myristate acetate, which downregulates the cAMP-regulated chloride efflux mechanism.	Tetradecanoylphorbol Acetate	165-190	vasoactive intestinal peptide	Bos taurus	72-102
7686304-7	1993	Chloride efflux from colon cancer cells is stimulated by cyclic AMP and vaso-active intestinal peptide (VIP), and can be inhibited by pretreatment of the cells with phorbol myristate acetate, which downregulates the cAMP-regulated chloride efflux mechanism.	Tetradecanoylphorbol Acetate	165-190	vasoactive intestinal peptide	Bos taurus	104-107
8352018-2	1993	The results showed that TPA (1-100 ng.ml-1) and lipopolysaccharides (LPS) (1-100 ng.ml-1) induced the release of TNF from PA-primed mouse peritoneal macrophages in dose- and time-dependent manners in vitro, and the effects of TPA and LPS were inhibited by H-7 (12.5-100 mumol.L-1) or quercetin (6.25-25 mumol.L-1) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	24-27	tumor necrosis factor	Mus musculus	113-116
8352018-2	1993	The results showed that TPA (1-100 ng.ml-1) and lipopolysaccharides (LPS) (1-100 ng.ml-1) induced the release of TNF from PA-primed mouse peritoneal macrophages in dose- and time-dependent manners in vitro, and the effects of TPA and LPS were inhibited by H-7 (12.5-100 mumol.L-1) or quercetin (6.25-25 mumol.L-1) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	226-229	tumor necrosis factor	Mus musculus	113-116
8382693-5	1993	Treatment of these cells with phytohemagglutinin and 12-O-tetradecanoylphorbol-13-acetate in the presence of fetal calf serum resulted in rapid induction of cyclin D2 RNA in early G1 and slower induction of cyclin D3 in late G1.	Tetradecanoylphorbol Acetate	53-89	cyclin D3	Homo sapiens	207-216
8440709-7	1993	Exposure of HepG2 cells to phorbol 12-myristate 13-acetate (PMA) or PMA-dexamethasone led to an increase in the 80-kDa IL-6 receptor mRNA and functional receptor protein.	Tetradecanoylphorbol Acetate	27-58	interleukin 6	Homo sapiens	119-123
8440709-7	1993	Exposure of HepG2 cells to phorbol 12-myristate 13-acetate (PMA) or PMA-dexamethasone led to an increase in the 80-kDa IL-6 receptor mRNA and functional receptor protein.	Tetradecanoylphorbol Acetate	60-63	interleukin 6	Homo sapiens	119-123
7679006-3	1993	However, in the presence of optimal concentrations of granulocyte colony-stimulating factor (G-CSF) or interleukin-6 (IL-6), TPA or bryostatin markedly elevated the number of colonies formed from the GM-CFC.	Tetradecanoylphorbol Acetate	125-128	interleukin 6	Homo sapiens	118-122
8440709-8	1993	Whereas treatment of HepG2 cells with PMA led to an increase in the formation of gp80.gp130.IL-6 complexes determined by cross-linking, no corresponding increase in high affinity binding sites was found.	Tetradecanoylphorbol Acetate	38-41	interleukin 6 receptor	Homo sapiens	81-85
8440709-8	1993	Whereas treatment of HepG2 cells with PMA led to an increase in the formation of gp80.gp130.IL-6 complexes determined by cross-linking, no corresponding increase in high affinity binding sites was found.	Tetradecanoylphorbol Acetate	38-41	interleukin 6	Homo sapiens	92-96
8440709-10	1993	Evidence is presented that the 80-kDa IL-6 receptor up-regulation by PMA-dexamethasone is caused by the depletion of protein kinase C since the protein kinase C inhibitor staurosporine mimics the effect of PMA-dexamethasone.	Tetradecanoylphorbol Acetate	69-72	interleukin 6	Homo sapiens	38-42
8094032-10	1993	These results suggest that although PMA-induced ICAM-1 expression is PKC dependent on HS 683 and SK-N-SH cells, the stimulation of ICAM-1 expression by retinoic acid and by IFN-gamma may be due to PKC inactivation at longer time points (24 h), as mimicked by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, staurosporine, or PKC depletion by high doses of PMA.	Tetradecanoylphorbol Acetate	36-39	proline rich transmembrane protein 2	Homo sapiens	69-72
8094032-10	1993	These results suggest that although PMA-induced ICAM-1 expression is PKC dependent on HS 683 and SK-N-SH cells, the stimulation of ICAM-1 expression by retinoic acid and by IFN-gamma may be due to PKC inactivation at longer time points (24 h), as mimicked by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, staurosporine, or PKC depletion by high doses of PMA.	Tetradecanoylphorbol Acetate	36-39	interferon gamma	Homo sapiens	173-182
8094032-10	1993	These results suggest that although PMA-induced ICAM-1 expression is PKC dependent on HS 683 and SK-N-SH cells, the stimulation of ICAM-1 expression by retinoic acid and by IFN-gamma may be due to PKC inactivation at longer time points (24 h), as mimicked by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, staurosporine, or PKC depletion by high doses of PMA.	Tetradecanoylphorbol Acetate	36-39	proline rich transmembrane protein 2	Homo sapiens	197-200
8094032-10	1993	These results suggest that although PMA-induced ICAM-1 expression is PKC dependent on HS 683 and SK-N-SH cells, the stimulation of ICAM-1 expression by retinoic acid and by IFN-gamma may be due to PKC inactivation at longer time points (24 h), as mimicked by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, staurosporine, or PKC depletion by high doses of PMA.	Tetradecanoylphorbol Acetate	36-39	proline rich transmembrane protein 2	Homo sapiens	197-200
7679896-9	1993	The phorbol ester 12-myristate 13-acetate (PMA) as well as the Ca2+ ionophore A23187 both stimulated tyrosine phosphorylation of proteins identical to those phosphorylated by thrombin, suggesting that activation of protein kinase C (PKC) and elevation of the cytosolic Ca2+ concentration alone are sufficient to induce tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	43-46	coagulation factor II	Mus musculus	175-183
8383432-15	1993	Taken together, these data suggest that glucose differentially interferes with activation of PLD but not phospholipase C. And, the fact that PMA-induced activation of PLD is not altered by glucose further suggests that a protein kinase C independent step leading to the activation of PLD may be altered by glucose.	Tetradecanoylphorbol Acetate	141-144	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	93-96
8382476-1	1993	Exposure of cells to phorbol 12-myristate 13-acetate (PMA) has been reported to result in resistance to the acute biological effects of insulin and an associated reduction in insulin-receptor tyrosine kinase activity.	Tetradecanoylphorbol Acetate	21-52	insulin	Homo sapiens	136-143
8382476-1	1993	Exposure of cells to phorbol 12-myristate 13-acetate (PMA) has been reported to result in resistance to the acute biological effects of insulin and an associated reduction in insulin-receptor tyrosine kinase activity.	Tetradecanoylphorbol Acetate	21-52	insulin	Homo sapiens	175-182
8382476-1	1993	Exposure of cells to phorbol 12-myristate 13-acetate (PMA) has been reported to result in resistance to the acute biological effects of insulin and an associated reduction in insulin-receptor tyrosine kinase activity.	Tetradecanoylphorbol Acetate	54-57	insulin	Homo sapiens	136-143
8382476-1	1993	Exposure of cells to phorbol 12-myristate 13-acetate (PMA) has been reported to result in resistance to the acute biological effects of insulin and an associated reduction in insulin-receptor tyrosine kinase activity.	Tetradecanoylphorbol Acetate	54-57	insulin	Homo sapiens	175-182
8382476-4	1993	Acute exposure (30 min) to PMA resulted in a transient decrease of insulin binding which is consistent with a decrease in receptor number.	Tetradecanoylphorbol Acetate	27-30	insulin	Homo sapiens	67-74
8382476-5	1993	Chronic (18 h) exposure to PMA (5 nM) resulted in inhibition of insulin-induced down-regulation of its cognate receptor.	Tetradecanoylphorbol Acetate	27-30	insulin	Homo sapiens	64-71
8382476-9	1993	In summary, PMA inhibited insulin-stimulated receptor down-regulation via activation of PKC.	Tetradecanoylphorbol Acetate	12-15	insulin	Homo sapiens	26-33
8432975-4	1993	After a longer, 20-h treatment with PMA (20 nM), a considerable portion of PKC was still membrane-associated, and the total amount of immunoreactive PKC was not reduced considerably.	Tetradecanoylphorbol Acetate	36-39	protein kinase C alpha	Homo sapiens	75-78
8432975-4	1993	After a longer, 20-h treatment with PMA (20 nM), a considerable portion of PKC was still membrane-associated, and the total amount of immunoreactive PKC was not reduced considerably.	Tetradecanoylphorbol Acetate	36-39	protein kinase C alpha	Homo sapiens	149-152
8432975-9	1993	We propose that Bryo inhibits PMA-induced T cell proliferation by causing rapid degradation of PKC, reflecting a requirement of persistent PKC stimulation (lasting approximately 48 h) for the activation of human T cells and progression through the cell cycle.	Tetradecanoylphorbol Acetate	30-33	protein kinase C alpha	Homo sapiens	95-98
8427707-0	1993	Regulation of interleukin-1ra, interleukin-1 alpha, and interleukin-1 beta production by human alveolar macrophages with phorbol myristate acetate, lipopolysaccharide, and interleukin-4.	Tetradecanoylphorbol Acetate	121-146	interleukin 1 beta	Homo sapiens	56-74
8430950-3	1993	The secretion of TNF alpha and IFN gamma was determined in intact (unstimulated) and phytohemagglutinin/phorbol myristate acetate (PHA + PMA)-stimulated BAL leukocyte cultures and compared with that in control cultures.	Tetradecanoylphorbol Acetate	104-129	tumor necrosis factor	Homo sapiens	17-26
8430950-3	1993	The secretion of TNF alpha and IFN gamma was determined in intact (unstimulated) and phytohemagglutinin/phorbol myristate acetate (PHA + PMA)-stimulated BAL leukocyte cultures and compared with that in control cultures.	Tetradecanoylphorbol Acetate	104-129	interferon gamma	Homo sapiens	31-40
8430950-4	1993	In all patients studied, the background and PHA + PMA-induced secretion of TNF alpha and IFN gamma was significantly (p &lt; 0.001) higher than that in parallel control cultures.	Tetradecanoylphorbol Acetate	50-53	tumor necrosis factor	Homo sapiens	75-84
8430950-4	1993	In all patients studied, the background and PHA + PMA-induced secretion of TNF alpha and IFN gamma was significantly (p &lt; 0.001) higher than that in parallel control cultures.	Tetradecanoylphorbol Acetate	50-53	interferon gamma	Homo sapiens	89-98
8383432-15	1993	Taken together, these data suggest that glucose differentially interferes with activation of PLD but not phospholipase C. And, the fact that PMA-induced activation of PLD is not altered by glucose further suggests that a protein kinase C independent step leading to the activation of PLD may be altered by glucose.	Tetradecanoylphorbol Acetate	141-144	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	167-170
8383432-15	1993	Taken together, these data suggest that glucose differentially interferes with activation of PLD but not phospholipase C. And, the fact that PMA-induced activation of PLD is not altered by glucose further suggests that a protein kinase C independent step leading to the activation of PLD may be altered by glucose.	Tetradecanoylphorbol Acetate	141-144	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	167-170
8435072-12	1993	The positive effect of both alpha MDG and TPA on ODC mRNA expression was suppressed when cells were incubated in hypertonic EBSS--G. From these results it is suggested that the uptake of Na(+)-dependent cotransported sugars increase ODC activity by enhancing ODC gene transcription and that this process may be dependent on cell volume expansion.	Tetradecanoylphorbol Acetate	42-45	ornithine decarboxylase 1	Sus scrofa	49-52
8435086-4	1993	Prior addition of both phorbol 12-myristate 13-acetate (PMA) and sapintoxin A (SAPA) inhibited fMLP-stimulated Mn2+ influx.	Tetradecanoylphorbol Acetate	23-54	formyl peptide receptor 1	Homo sapiens	95-99
8435086-4	1993	Prior addition of both phorbol 12-myristate 13-acetate (PMA) and sapintoxin A (SAPA) inhibited fMLP-stimulated Mn2+ influx.	Tetradecanoylphorbol Acetate	56-59	formyl peptide receptor 1	Homo sapiens	95-99
8435072-12	1993	The positive effect of both alpha MDG and TPA on ODC mRNA expression was suppressed when cells were incubated in hypertonic EBSS--G. From these results it is suggested that the uptake of Na(+)-dependent cotransported sugars increase ODC activity by enhancing ODC gene transcription and that this process may be dependent on cell volume expansion.	Tetradecanoylphorbol Acetate	42-45	ornithine decarboxylase 1	Sus scrofa	233-236
8435072-12	1993	The positive effect of both alpha MDG and TPA on ODC mRNA expression was suppressed when cells were incubated in hypertonic EBSS--G. From these results it is suggested that the uptake of Na(+)-dependent cotransported sugars increase ODC activity by enhancing ODC gene transcription and that this process may be dependent on cell volume expansion.	Tetradecanoylphorbol Acetate	42-45	ornithine decarboxylase 1	Sus scrofa	233-236
8436181-3	1993	Shedding of the gp80 protein was strongly induced by 4 beta-phorbol-12-myristate-13-acetate, indicating that the process was regulated by protein kinase C (PKC).	Tetradecanoylphorbol Acetate	53-91	interleukin 6 receptor	Homo sapiens	16-20
8435086-19	1993	However, when fMLP was only able to evoke a small increase in [Ca2+]i (to a peak of 400 nM), potentiation by PMA was unaffected but potentiation by SAPA and RX was considerably reduced.	Tetradecanoylphorbol Acetate	109-112	formyl peptide receptor 1	Homo sapiens	14-18
7678802-3	1993	Effectiveness of PKC desensitization was confirmed by the fact that after TPA pretreatment, short-term (1-h) exposure to TPA was no longer able to trigger PRL release.	Tetradecanoylphorbol Acetate	121-124	prolactin	Homo sapiens	155-158
7678802-10	1993	In addition, chronic exposure to TPA completely suppressed PRL mRNA inhibition induced by nifedipine, a dihydropyridine antagonist which blocks voltage-dependent Ca2+ channels.	Tetradecanoylphorbol Acetate	33-36	prolactin	Homo sapiens	59-62
7678802-11	1993	TPA desensitization also affected the action of bromocriptine, FK or nifedipine on PRL release measured under the same conditions.	Tetradecanoylphorbol Acetate	0-3	prolactin	Homo sapiens	83-86
8440336-1	1993	The exposure of human peripheral blood mononuclear cells to extremely low frequency pulsed electromagnetic fields (PEMFs) increased both the spontaneous and the PHA- and TPA-induced production of interleukin-1 (IL-1) and IL-6.	Tetradecanoylphorbol Acetate	170-173	interleukin 6	Homo sapiens	221-225
8423347-7	1993	T cell lines generated against Tct proliferated in response to parasite lysate only in the presence of autologous APC and produced IL-2, IL-6, and IFN-gamma but not IL-4 in response to PMA plus ionomycin.	Tetradecanoylphorbol Acetate	185-188	interleukin 2	Homo sapiens	131-135
8428793-1	1993	A comparison of the production of tissue-type plasminogen activator (t-PA) and gelatinases A and B was made at the mRNA and protein levels in human Bowes melanoma cells treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	182-207	plasminogen activator, tissue type	Homo sapiens	34-67
7679371-4	1993	The O2- production induced by substance P was also found to be fivefold higher in exudate cells, while the metabolic response to other stimulants such as concanavalin A (con A), phorbol-myristate acetate (PMA), NaF, and immunocomplexes was not primed.	Tetradecanoylphorbol Acetate	205-208	tachykinin precursor 1	Homo sapiens	30-41
8428793-1	1993	A comparison of the production of tissue-type plasminogen activator (t-PA) and gelatinases A and B was made at the mRNA and protein levels in human Bowes melanoma cells treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	182-207	plasminogen activator, tissue type	Homo sapiens	69-73
8428793-1	1993	A comparison of the production of tissue-type plasminogen activator (t-PA) and gelatinases A and B was made at the mRNA and protein levels in human Bowes melanoma cells treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	209-212	plasminogen activator, tissue type	Homo sapiens	34-67
8423347-7	1993	T cell lines generated against Tct proliferated in response to parasite lysate only in the presence of autologous APC and produced IL-2, IL-6, and IFN-gamma but not IL-4 in response to PMA plus ionomycin.	Tetradecanoylphorbol Acetate	185-188	interferon gamma	Homo sapiens	147-156
8381194-5	1993	TNF-alpha synthesis and secretion was, however, induced to high levels by stimulation of the B-CLL cells with interleukin-2 (IL-2) after activation by 12-O-tetradecanoylphorbol-13-acetate (TPA) or Staphylococcus aureus Cowan strain I (SAC) and B-cell stimulatory factor-MP6 (thioredoxin).	Tetradecanoylphorbol Acetate	151-187	tumor necrosis factor	Rattus norvegicus	0-9
8381194-5	1993	TNF-alpha synthesis and secretion was, however, induced to high levels by stimulation of the B-CLL cells with interleukin-2 (IL-2) after activation by 12-O-tetradecanoylphorbol-13-acetate (TPA) or Staphylococcus aureus Cowan strain I (SAC) and B-cell stimulatory factor-MP6 (thioredoxin).	Tetradecanoylphorbol Acetate	189-192	tumor necrosis factor	Rattus norvegicus	0-9
8381194-6	1993	A moderate increase in TNF-alpha secretion was also induced by TPA or IL-2 alone.	Tetradecanoylphorbol Acetate	63-66	tumor necrosis factor	Rattus norvegicus	23-32
8095076-7	1993	ST also blocked the reduction in PCSA induced by phorbol myristate acetate (PMA, 300 nM).	Tetradecanoylphorbol Acetate	49-74	somatostatin	Rattus norvegicus	0-2
8381194-8	1993	The cell surface expression of TNF-alpha receptors (TNF-R), as determined by binding assay using 125I-labelled recombinant TNF-alpha (rTNF-alpha), was also induced after SAC or TPA activation, but shed receptors (TNF-binding proteins) were only observed after TPA activation.	Tetradecanoylphorbol Acetate	177-180	tumor necrosis factor	Rattus norvegicus	31-40
8095076-7	1993	ST also blocked the reduction in PCSA induced by phorbol myristate acetate (PMA, 300 nM).	Tetradecanoylphorbol Acetate	76-79	somatostatin	Rattus norvegicus	0-2
8381194-8	1993	The cell surface expression of TNF-alpha receptors (TNF-R), as determined by binding assay using 125I-labelled recombinant TNF-alpha (rTNF-alpha), was also induced after SAC or TPA activation, but shed receptors (TNF-binding proteins) were only observed after TPA activation.	Tetradecanoylphorbol Acetate	177-180	tumor necrosis factor	Rattus norvegicus	123-132
8381194-8	1993	The cell surface expression of TNF-alpha receptors (TNF-R), as determined by binding assay using 125I-labelled recombinant TNF-alpha (rTNF-alpha), was also induced after SAC or TPA activation, but shed receptors (TNF-binding proteins) were only observed after TPA activation.	Tetradecanoylphorbol Acetate	177-180	tumor necrosis factor	Rattus norvegicus	134-144
8381194-8	1993	The cell surface expression of TNF-alpha receptors (TNF-R), as determined by binding assay using 125I-labelled recombinant TNF-alpha (rTNF-alpha), was also induced after SAC or TPA activation, but shed receptors (TNF-binding proteins) were only observed after TPA activation.	Tetradecanoylphorbol Acetate	260-263	tumor necrosis factor	Rattus norvegicus	31-40
8381194-8	1993	The cell surface expression of TNF-alpha receptors (TNF-R), as determined by binding assay using 125I-labelled recombinant TNF-alpha (rTNF-alpha), was also induced after SAC or TPA activation, but shed receptors (TNF-binding proteins) were only observed after TPA activation.	Tetradecanoylphorbol Acetate	260-263	tumor necrosis factor	Rattus norvegicus	134-144
8426746-3	1993	Deletion and mutation analysis revealed that three motifs, homologous to the binding sites for AP-1, NF-kappa B, and Sp-1 proteins, contributed positively to induction by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and tumor necrosis factor alpha (TNF alpha).	Tetradecanoylphorbol Acetate	171-208	tumor necrosis factor	Homo sapiens	248-257
8457630-3	1993	Here we report that HUT78 cells can be induced to produce IL-4 either by CD3 stimulation under cross-linking conditions or by soluble CD3 mAbs in the presence of PMA.	Tetradecanoylphorbol Acetate	162-165	interleukin 4	Homo sapiens	58-62
8457632-1	1993	Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro.	Tetradecanoylphorbol Acetate	79-104	interleukin 1 beta	Homo sapiens	150-168
8457632-1	1993	Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro.	Tetradecanoylphorbol Acetate	79-104	interleukin 1 beta	Homo sapiens	170-179
8457632-1	1993	Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro.	Tetradecanoylphorbol Acetate	106-109	interleukin 1 beta	Homo sapiens	150-168
8457632-1	1993	Three different stimuli [lipopolysaccharide (LPS), concanavalin A (Con A), and phorbol myristate acetate (PMA)] all induced production and release of interleukin-1 beta (IL-1 beta) from human monocytes in vitro.	Tetradecanoylphorbol Acetate	106-109	interleukin 1 beta	Homo sapiens	170-179
8457632-6	1993	Challenge with PMA induced low levels of IL-1 beta production with a relatively large percentage released.	Tetradecanoylphorbol Acetate	15-18	interleukin 1 beta	Homo sapiens	41-50
8426742-0	1993	Raf revertant cells resist transformation by non-nuclear oncogenes and are deficient in the induction of early response genes by TPA and serum.	Tetradecanoylphorbol Acetate	129-132	zinc fingers and homeoboxes 2	Mus musculus	0-3
8472854-7	1993	Short-term exposure of both cell types to phorbol myristate acetate (4 beta-PMA) activated PKC, whilst prolonged exposure of human granulosa-lutein cells to 4 beta-PMA led to a &gt; 85% loss of total PKC activity.	Tetradecanoylphorbol Acetate	42-67	proline rich transmembrane protein 2	Homo sapiens	91-94
8472854-7	1993	Short-term exposure of both cell types to phorbol myristate acetate (4 beta-PMA) activated PKC, whilst prolonged exposure of human granulosa-lutein cells to 4 beta-PMA led to a &gt; 85% loss of total PKC activity.	Tetradecanoylphorbol Acetate	42-67	proline rich transmembrane protein 2	Homo sapiens	200-203
8426746-3	1993	Deletion and mutation analysis revealed that three motifs, homologous to the binding sites for AP-1, NF-kappa B, and Sp-1 proteins, contributed positively to induction by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and tumor necrosis factor alpha (TNF alpha).	Tetradecanoylphorbol Acetate	210-213	tumor necrosis factor	Homo sapiens	219-246
8426746-3	1993	Deletion and mutation analysis revealed that three motifs, homologous to the binding sites for AP-1, NF-kappa B, and Sp-1 proteins, contributed positively to induction by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and tumor necrosis factor alpha (TNF alpha).	Tetradecanoylphorbol Acetate	210-213	tumor necrosis factor	Homo sapiens	248-257
8426746-6	1993	Comparison of the findings with those for the promoters of other TPA-inducible matrix metalloproteinases, interstitial collagenase and stromelysin 1, revealed that the signal to the AP-1 sites is common for the TPA-inducibility of the genes but that the signals to the kappa B or Sp-1 sites, which are not present in interstitial collagenase and stromelysin 1 promoters, are the unique determinant for the inducibility of the 92 kDa type IV collagenase gene.	Tetradecanoylphorbol Acetate	65-68	matrix metallopeptidase 3	Homo sapiens	135-148
8426746-6	1993	Comparison of the findings with those for the promoters of other TPA-inducible matrix metalloproteinases, interstitial collagenase and stromelysin 1, revealed that the signal to the AP-1 sites is common for the TPA-inducibility of the genes but that the signals to the kappa B or Sp-1 sites, which are not present in interstitial collagenase and stromelysin 1 promoters, are the unique determinant for the inducibility of the 92 kDa type IV collagenase gene.	Tetradecanoylphorbol Acetate	65-68	matrix metallopeptidase 3	Homo sapiens	346-359
8426746-6	1993	Comparison of the findings with those for the promoters of other TPA-inducible matrix metalloproteinases, interstitial collagenase and stromelysin 1, revealed that the signal to the AP-1 sites is common for the TPA-inducibility of the genes but that the signals to the kappa B or Sp-1 sites, which are not present in interstitial collagenase and stromelysin 1 promoters, are the unique determinant for the inducibility of the 92 kDa type IV collagenase gene.	Tetradecanoylphorbol Acetate	211-214	matrix metallopeptidase 3	Homo sapiens	135-148
8426746-6	1993	Comparison of the findings with those for the promoters of other TPA-inducible matrix metalloproteinases, interstitial collagenase and stromelysin 1, revealed that the signal to the AP-1 sites is common for the TPA-inducibility of the genes but that the signals to the kappa B or Sp-1 sites, which are not present in interstitial collagenase and stromelysin 1 promoters, are the unique determinant for the inducibility of the 92 kDa type IV collagenase gene.	Tetradecanoylphorbol Acetate	211-214	matrix metallopeptidase 3	Homo sapiens	346-359
8380584-2	1993	On the other hand, W-7, a calmodulin (CaM) inhibitor, almost completely suppressed the enhancing activity of TPA, suggesting the involvement of CaM in the enhancement by TPA of carbacyclin-induced cAMP formation.	Tetradecanoylphorbol Acetate	109-112	calmodulin 1	Homo sapiens	26-36
8421910-7	1993	We also observed that the detectable levels of p37 and p50 in the infected MOLT-4 cells were greatly reduced after phorbol ester (TPA) treatment under the condition of which HIV-1 gene expression was increased by about fivefold.	Tetradecanoylphorbol Acetate	130-133	nuclear factor kappa B subunit 1	Homo sapiens	55-58
8380584-2	1993	On the other hand, W-7, a calmodulin (CaM) inhibitor, almost completely suppressed the enhancing activity of TPA, suggesting the involvement of CaM in the enhancement by TPA of carbacyclin-induced cAMP formation.	Tetradecanoylphorbol Acetate	109-112	calmodulin 1	Homo sapiens	38-41
8380584-2	1993	On the other hand, W-7, a calmodulin (CaM) inhibitor, almost completely suppressed the enhancing activity of TPA, suggesting the involvement of CaM in the enhancement by TPA of carbacyclin-induced cAMP formation.	Tetradecanoylphorbol Acetate	109-112	calmodulin 1	Homo sapiens	144-147
8380584-2	1993	On the other hand, W-7, a calmodulin (CaM) inhibitor, almost completely suppressed the enhancing activity of TPA, suggesting the involvement of CaM in the enhancement by TPA of carbacyclin-induced cAMP formation.	Tetradecanoylphorbol Acetate	170-173	calmodulin 1	Homo sapiens	144-147
8380584-3	1993	The enhancing activity of TPA disappeared in TPA-treated cells permeabilized with saponin in the presence of Ca2+, but reconstitution with CaM in the permeable cells resulted in remarkable restoration of the action of TPA.	Tetradecanoylphorbol Acetate	26-29	calmodulin 1	Homo sapiens	139-142
8273591-1	1993	Several protein kinase inhibitors (PKIs) were investigated for their effects on IL-1 beta, TNF alpha and PMA-induced IL-8 production from human umbilical vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	117-121
8381083-5	1993	Inhibitors of phospholipase A2 inhibit the PMA activation of the oxidase.	Tetradecanoylphorbol Acetate	43-46	phospholipase A2 group IB	Homo sapiens	14-30
7682303-4	1993	The data obtained with TPA were tentatively correlated with the amounts of immunoreactive PKC alpha.	Tetradecanoylphorbol Acetate	23-26	protein kinase C alpha	Homo sapiens	90-99
8093247-9	1993	Phosphorylation of P-glycoprotein, the cellular mediator of the MDR phenotype, was increased &gt; 20-fold in the unstimulated MCF-7-MDR cell line and its phosphorylation was further increased 2-fold in response to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	214-245	ATP binding cassette subfamily B member 1	Homo sapiens	19-33
8512018-7	1993	After treatment with PMA and LPS, IL-1 alpha was detected in the culture fluid from two other lines and IL-1 beta in the medium from three lines.	Tetradecanoylphorbol Acetate	21-24	interleukin 1 beta	Homo sapiens	104-113
8273561-5	1993	With the addition of TY 21.6, the binding of PMA-stimulated BAL cells to hVCAM-1 was inhibited by 57 +/- 5%.	Tetradecanoylphorbol Acetate	45-48	vascular cell adhesion molecule 1	Homo sapiens	73-80
8381598-1	1993	After the intravenous injection of recombinant human tumor necrosis factor (TNF)-alpha (6.0 x 10(5) U) into rats, phorbol 12-myristate 13-acetate (PMA)-stimulated superoxide anion (O2-) secretion was enhanced in suspensions of alveolar macrophages (AM phi) compared with saline-treated controls.	Tetradecanoylphorbol Acetate	114-145	tumor necrosis factor	Homo sapiens	53-86
8381598-1	1993	After the intravenous injection of recombinant human tumor necrosis factor (TNF)-alpha (6.0 x 10(5) U) into rats, phorbol 12-myristate 13-acetate (PMA)-stimulated superoxide anion (O2-) secretion was enhanced in suspensions of alveolar macrophages (AM phi) compared with saline-treated controls.	Tetradecanoylphorbol Acetate	147-150	tumor necrosis factor	Homo sapiens	53-86
8430775-2	1993	A 24-h pretreatment of VSM cells with 200 nM phorbol 12-myristate 13-acetate (PMA) completely abolished immunologically reactive PKC activity.	Tetradecanoylphorbol Acetate	45-76	proline rich transmembrane protein 2	Homo sapiens	129-132
8381612-6	1993	However, use of PMA to cause feedback inhibition of D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] formation blocked the effect of ANG II on agonist-stimulated cAMP formation, and the time course for this effect of PMA paralleled its inhibitory effect on Ins(1,4,5)P3 production.	Tetradecanoylphorbol Acetate	16-19	angiotensinogen	Rattus norvegicus	134-140
8381612-6	1993	However, use of PMA to cause feedback inhibition of D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] formation blocked the effect of ANG II on agonist-stimulated cAMP formation, and the time course for this effect of PMA paralleled its inhibitory effect on Ins(1,4,5)P3 production.	Tetradecanoylphorbol Acetate	218-221	angiotensinogen	Rattus norvegicus	134-140
8430775-2	1993	A 24-h pretreatment of VSM cells with 200 nM phorbol 12-myristate 13-acetate (PMA) completely abolished immunologically reactive PKC activity.	Tetradecanoylphorbol Acetate	78-81	proline rich transmembrane protein 2	Homo sapiens	129-132
8430775-4	1993	Similarly, acute activation of PKC by treatment with 200 nM PMA for 10 min had no effect on PDGF-mediated [3H]thymidine incorporation.	Tetradecanoylphorbol Acetate	60-63	proline rich transmembrane protein 2	Homo sapiens	31-34
8417800-12	1993	Furthermore, it appeared that the induction of IL-4 mRNA was dependent on protein synthesis because cycloheximide (CHX) blocked the Con A- and Con A+PMA-induced expression of IL-4 mRNA.	Tetradecanoylphorbol Acetate	149-152	interleukin 4	Homo sapiens	47-51
7678725-0	1993	Regulation of the TNF-alpha receptor in human osteosarcoma cells: role of microtubules and of protein kinase C. The effect of the tumor promoter 4 beta-phorbol 12-myristate 13-acetate and of the phosphatases inhibitor okadaic acid on the binding of tumor necrosis factor-alpha (TNF-alpha) to a human osteogenic sarcoma cell line (Saos-2) was investigated.	Tetradecanoylphorbol Acetate	147-183	tumor necrosis factor	Homo sapiens	18-27
7678725-4	1993	Vinblastine plus PMA was additive in fully preventing TNF binding.	Tetradecanoylphorbol Acetate	17-20	tumor necrosis factor	Homo sapiens	54-57
8285856-11	1993	Relative abundance of different phosphorylated Cx43 forms was increased after 1 h exposure to DDT (10 micrograms) and 30 min exposure to TPA (0.1 microgram/ml).	Tetradecanoylphorbol Acetate	137-140	gap junction protein, alpha 1	Rattus norvegicus	47-51
8417800-12	1993	Furthermore, it appeared that the induction of IL-4 mRNA was dependent on protein synthesis because cycloheximide (CHX) blocked the Con A- and Con A+PMA-induced expression of IL-4 mRNA.	Tetradecanoylphorbol Acetate	149-152	interleukin 4	Homo sapiens	175-179
8425229-6	1993	When a combination of PHA and 12-O-tetradecanoyl-13-O-acetyl phorbol (TPA) was used, a small increase in IL-2 production was observed only in the presence of vinblastine (10 microM).	Tetradecanoylphorbol Acetate	70-73	interleukin 2	Homo sapiens	105-109
8380379-8	1993	FSH, phorbol myristate acetate, and IL-1 alpha augmented Sertoli cell IL-6 secretion in a dose-dependent manner.	Tetradecanoylphorbol Acetate	5-30	interleukin 6	Rattus norvegicus	70-74
8419187-4	1993	After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells.	Tetradecanoylphorbol Acetate	23-54	interleukin 4	Homo sapiens	122-126
8093439-3	1993	However, whereas T cell clones showed enhanced IL-4 production when phorbol 12-myristate 13-acetate (PMA) was used in addition to anti-CD2 and anti-CD28, IL-4 production by fresh T cells was inhibited by the presence of PMA.	Tetradecanoylphorbol Acetate	68-99	interleukin 4	Homo sapiens	47-51
8093439-3	1993	However, whereas T cell clones showed enhanced IL-4 production when phorbol 12-myristate 13-acetate (PMA) was used in addition to anti-CD2 and anti-CD28, IL-4 production by fresh T cells was inhibited by the presence of PMA.	Tetradecanoylphorbol Acetate	68-99	interleukin 4	Homo sapiens	154-158
7678228-3	1993	In addition, mB7 can synergize with phorbol 12-myristate 13-acetate (PMA) to induce T cell activation in an alternative pathway.	Tetradecanoylphorbol Acetate	36-67	CD52 antigen	Mus musculus	13-16
8419187-4	1993	After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells.	Tetradecanoylphorbol Acetate	23-54	interleukin 2	Homo sapiens	209-213
7678228-3	1993	In addition, mB7 can synergize with phorbol 12-myristate 13-acetate (PMA) to induce T cell activation in an alternative pathway.	Tetradecanoylphorbol Acetate	69-72	CD52 antigen	Mus musculus	13-16
8093439-3	1993	However, whereas T cell clones showed enhanced IL-4 production when phorbol 12-myristate 13-acetate (PMA) was used in addition to anti-CD2 and anti-CD28, IL-4 production by fresh T cells was inhibited by the presence of PMA.	Tetradecanoylphorbol Acetate	101-104	interleukin 4	Homo sapiens	47-51
8419187-4	1993	After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells.	Tetradecanoylphorbol Acetate	23-54	interferon gamma	Homo sapiens	243-259
8419187-4	1993	After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells.	Tetradecanoylphorbol Acetate	23-54	interferon gamma	Homo sapiens	261-270
8419187-4	1993	After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells.	Tetradecanoylphorbol Acetate	23-54	CD4 molecule	Homo sapiens	312-315
8419187-4	1993	After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells.	Tetradecanoylphorbol Acetate	56-59	interleukin 4	Homo sapiens	122-126
8419187-4	1993	After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells.	Tetradecanoylphorbol Acetate	56-59	interleukin 2	Homo sapiens	209-213
8419187-4	1993	After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells.	Tetradecanoylphorbol Acetate	56-59	interferon gamma	Homo sapiens	243-259
8419187-4	1993	After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells.	Tetradecanoylphorbol Acetate	56-59	interferon gamma	Homo sapiens	261-270
8419187-4	1993	After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells.	Tetradecanoylphorbol Acetate	56-59	CD4 molecule	Homo sapiens	312-315
7860222-2	1993	The promoter and adjacent regulatory sequences of the 92-kD type IV collagenase have been identified previously and three cis-acting elements homologous to the binding sites for AP-1, NF-KB and SP-1 proteins contributed to induction of the promoter activity by 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumor necrosis factor (TNF-alpha) in HT1080 cells.	Tetradecanoylphorbol Acetate	261-297	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-182
8320080-4	1993	A phorbol-ester (PMA), on the other hand, enhanced only slightly the proportion of PE-IL-2 binding cells.	Tetradecanoylphorbol Acetate	17-20	interleukin 2	Homo sapiens	86-90
8443122-1	1993	Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA).	Tetradecanoylphorbol Acetate	154-157	interleukin 2	Homo sapiens	17-21
8443122-1	1993	Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA).	Tetradecanoylphorbol Acetate	154-157	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
7860222-2	1993	The promoter and adjacent regulatory sequences of the 92-kD type IV collagenase have been identified previously and three cis-acting elements homologous to the binding sites for AP-1, NF-KB and SP-1 proteins contributed to induction of the promoter activity by 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumor necrosis factor (TNF-alpha) in HT1080 cells.	Tetradecanoylphorbol Acetate	261-297	tumor necrosis factor	Homo sapiens	331-340
8443122-1	1993	Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA).	Tetradecanoylphorbol Acetate	154-157	interferon gamma	Homo sapiens	51-67
7860222-2	1993	The promoter and adjacent regulatory sequences of the 92-kD type IV collagenase have been identified previously and three cis-acting elements homologous to the binding sites for AP-1, NF-KB and SP-1 proteins contributed to induction of the promoter activity by 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumor necrosis factor (TNF-alpha) in HT1080 cells.	Tetradecanoylphorbol Acetate	299-302	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-182
7678596-4	1993	Since protein kinase C (PKC) is an important mediator of the effects of TPA, we have investigated the nature of this differential growth response by examining PKC expression and activity in primary cultures of human neonatal melanocytes and metastatic melanoma cell strains.	Tetradecanoylphorbol Acetate	72-75	proline rich transmembrane protein 2	Homo sapiens	6-22
8439651-6	1993	Thrombin and phorbol myristate acetate appeared to stimulate endothelin-1 peptide by activating protein kinase C, because the protein kinase inhibitor 1-(5-isoquinolinyl-sulfonyl)-3-methyl-piperazine abolished the thrombin- and phorbol myristate acetate-induced rise in endothelin-1 but had no effect on basal production.	Tetradecanoylphorbol Acetate	228-253	coagulation factor II	Rattus norvegicus	0-8
8439651-6	1993	Thrombin and phorbol myristate acetate appeared to stimulate endothelin-1 peptide by activating protein kinase C, because the protein kinase inhibitor 1-(5-isoquinolinyl-sulfonyl)-3-methyl-piperazine abolished the thrombin- and phorbol myristate acetate-induced rise in endothelin-1 but had no effect on basal production.	Tetradecanoylphorbol Acetate	228-253	endothelin 1	Rattus norvegicus	61-73
8439651-7	1993	The stimulatory effect of thrombin was also markedly diminished in glomerular epithelial cells that had been depleted of protein kinase C by prolonged preincubation with a high dose of phorbol myristate acetate.	Tetradecanoylphorbol Acetate	185-210	coagulation factor II	Rattus norvegicus	26-34
8439651-5	1993	Transforming growth factor-beta, complement C5b-9, thrombin, and phorbol myristate acetate significantly enhanced endothelin-1 peptide synthesis in glomerular epithelial cells (45, 15, 55, and 25% above basal levels at 24 h, respectively), whereas epidermal growth factor had no effect.	Tetradecanoylphorbol Acetate	65-90	endothelin 1	Rattus norvegicus	114-126
8439651-6	1993	Thrombin and phorbol myristate acetate appeared to stimulate endothelin-1 peptide by activating protein kinase C, because the protein kinase inhibitor 1-(5-isoquinolinyl-sulfonyl)-3-methyl-piperazine abolished the thrombin- and phorbol myristate acetate-induced rise in endothelin-1 but had no effect on basal production.	Tetradecanoylphorbol Acetate	13-38	endothelin 1	Rattus norvegicus	61-73
8439651-6	1993	Thrombin and phorbol myristate acetate appeared to stimulate endothelin-1 peptide by activating protein kinase C, because the protein kinase inhibitor 1-(5-isoquinolinyl-sulfonyl)-3-methyl-piperazine abolished the thrombin- and phorbol myristate acetate-induced rise in endothelin-1 but had no effect on basal production.	Tetradecanoylphorbol Acetate	13-38	coagulation factor II	Rattus norvegicus	214-222
7678596-4	1993	Since protein kinase C (PKC) is an important mediator of the effects of TPA, we have investigated the nature of this differential growth response by examining PKC expression and activity in primary cultures of human neonatal melanocytes and metastatic melanoma cell strains.	Tetradecanoylphorbol Acetate	72-75	proline rich transmembrane protein 2	Homo sapiens	24-27
7678596-10	1993	Furthermore, differential expression of PKC isotypes may explain the different effects of TPA on melanocyte and melanoma cell growth.	Tetradecanoylphorbol Acetate	90-93	proline rich transmembrane protein 2	Homo sapiens	40-43
7907909-5	1993	The long-term increase of TH activity was addressed using the drug reserpine known to modify the secretion of neurotransmitters and the tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	136-165	tyrosine hydroxylase	Homo sapiens	26-28
8382749-9	1993	Addition of a direct activator of protein kinase C, phorbol 12-myristate 13-acetate, led to inhibition of the endothelin-1 evoked phosphoinositide turnover but the rate of desensitization was not affected.	Tetradecanoylphorbol Acetate	52-83	endothelin 1	Rattus norvegicus	110-122
8380863-3	1993	After incubating intact U937 cells with phorbol 12-myristate 13-acetate (PMA, 100 nM) at 22 degrees C for 30 min, the specific binding of 125I-beta-endorphin was maximally reduced by approximately 40%.	Tetradecanoylphorbol Acetate	40-71	proopiomelanocortin	Homo sapiens	143-157
8380829-0	1993	Analysis of the 5"-upstream promoter region of human involucrin gene: activation by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	84-120	involucrin	Homo sapiens	53-63
8380829-3	1993	We have isolated a 5"-upstream region of human involucrin gene and examined its TPA-dependent promoter activity.	Tetradecanoylphorbol Acetate	80-83	involucrin	Homo sapiens	47-57
8423632-1	1993	The physiological importance of protein kinase C during oligodendrocyte progenitor maturation was investigated by analyzing the effects of the protein kinase C activator phorbol 12-myristate 13-acetate (TPA) on the morphology, proliferation, and differentiation of oligodendrocytes at sequential stages of development.	Tetradecanoylphorbol Acetate	170-201	plasminogen activator, tissue type	Homo sapiens	203-206
8380863-3	1993	After incubating intact U937 cells with phorbol 12-myristate 13-acetate (PMA, 100 nM) at 22 degrees C for 30 min, the specific binding of 125I-beta-endorphin was maximally reduced by approximately 40%.	Tetradecanoylphorbol Acetate	73-76	proopiomelanocortin	Homo sapiens	143-157
7907909-5	1993	The long-term increase of TH activity was addressed using the drug reserpine known to modify the secretion of neurotransmitters and the tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	167-170	tyrosine hydroxylase	Homo sapiens	26-28
18475504-4	1993	IL-2 had no effect on neutrophil migration, phagocytosis, deoxyglucose uptake or degranulation, ionocytes demonstrated a greater sensitivity to IL-2 with suppression of monocyte adherence, random and stimulated migration, glucose uptake and hexose monophosphate shunt activity, even after addition of phorbol myristate acetate.	Tetradecanoylphorbol Acetate	301-326	interleukin 2	Homo sapiens	144-148
7679173-1	1993	In this paper we report that differentiation of the human promyelocytic leukemia cell line, HL60, along the myelocytic pathway, induced by retinoic acid (RA), or monocytic pathway, induced by phorbol-myristate acetate (PMA) and gamma interferon (IFN), was accompanied by a significant decline in 1,25-dihydroxycholecalciferol (1,25(OH)2D3) binding (control: 30.3 +/- 3.0 fM/10(6) cells; RA treated: 6.8 + 2.5 fM/10(6) cells; PMA treated: 12.3 +/- 6.7 fM/10(6) cells and IFN treated: 16.0 +/- 5.0 fM/10(6) cells).	Tetradecanoylphorbol Acetate	192-217	interferon alpha 1	Homo sapiens	228-250
7679173-1	1993	In this paper we report that differentiation of the human promyelocytic leukemia cell line, HL60, along the myelocytic pathway, induced by retinoic acid (RA), or monocytic pathway, induced by phorbol-myristate acetate (PMA) and gamma interferon (IFN), was accompanied by a significant decline in 1,25-dihydroxycholecalciferol (1,25(OH)2D3) binding (control: 30.3 +/- 3.0 fM/10(6) cells; RA treated: 6.8 + 2.5 fM/10(6) cells; PMA treated: 12.3 +/- 6.7 fM/10(6) cells and IFN treated: 16.0 +/- 5.0 fM/10(6) cells).	Tetradecanoylphorbol Acetate	192-217	interferon alpha 1	Homo sapiens	246-249
8352882-7	1993	When MEK and HEK cultures were treated with TPA for 3 h, less than 30% of the control level of PKC activity was detected, indicating that TPA-induced downregulation of PKC was similar in MEKs and HEKs.	Tetradecanoylphorbol Acetate	44-47	protein kinase C alpha	Homo sapiens	95-98
8231967-7	1993	Using these TPA-treated cells, it was shown in this report that calcium influx, phospholipase A2 and C activities were important to induce cytotoxic action of leukocidin after binding of leukocidin to specific receptors on the cells.	Tetradecanoylphorbol Acetate	12-15	phospholipase A2 group IB	Homo sapiens	80-96
8352882-7	1993	When MEK and HEK cultures were treated with TPA for 3 h, less than 30% of the control level of PKC activity was detected, indicating that TPA-induced downregulation of PKC was similar in MEKs and HEKs.	Tetradecanoylphorbol Acetate	138-141	protein kinase C alpha	Homo sapiens	168-171
8352882-8	1993	After treatment with TPA, MEK cultures produced a large induction of both c-jun and c-fos mRNA by 60 min, as determined by northern blot analysis, and a large induction of ODC mRNA and enzyme activity by 6 h. TPA treatment of cultured HEKs, however, did not induce ODC activity; in fact, less activity, compared with that of control cultures, was observed.	Tetradecanoylphorbol Acetate	21-24	mitogen-activated protein kinase kinase 7	Homo sapiens	26-29
8352882-1	1993	The goal of this study was to compare the response of mouse epidermal keratinocytes (MEKs) and human epidermal keratinocytes (HEKs) to 12-O-tetradecanoylphorbol-13-acetate (TPA) with respect to the activation and downregulation of protein kinase C (PKC), the expression of c-jun and c-fos, and the expression and induction of ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	135-171	protein kinase C alpha	Homo sapiens	249-252
8352882-6	1993	Activation of partially purified total PKC by TPA was similar in freshly isolated and cultured MEKs and HEKs, indicating that the two species were similar in this regard and that 2 wk of culture did not alter this characteristic.	Tetradecanoylphorbol Acetate	46-49	protein kinase C alpha	Homo sapiens	39-42
8352891-9	1993	Both p53-hybridizing transcripts were downregulated by prolonged 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment (24 h) regardless of the stage of progression.	Tetradecanoylphorbol Acetate	103-106	tumor protein p53	Homo sapiens	5-8
8352882-8	1993	After treatment with TPA, MEK cultures produced a large induction of both c-jun and c-fos mRNA by 60 min, as determined by northern blot analysis, and a large induction of ODC mRNA and enzyme activity by 6 h. TPA treatment of cultured HEKs, however, did not induce ODC activity; in fact, less activity, compared with that of control cultures, was observed.	Tetradecanoylphorbol Acetate	209-212	mitogen-activated protein kinase kinase 7	Homo sapiens	26-29
8352891-10	1993	We conclude from this study that in JB6 variants (1) mutational activation of Ha-ras and inactivation of p53 are unlikely to be involved in preneoplastic progression; (2) increased amounts of p53 protein may be involved in a subset of transformed cells, possibly reflecting a longer half-life, as demonstrated in other systems; and (3) late downregulation of p53 mRNA but not protein expression may be a secondary response in the TPA-mediated signal transduction pathway.	Tetradecanoylphorbol Acetate	430-433	tumor protein p53	Homo sapiens	192-195
8352891-10	1993	We conclude from this study that in JB6 variants (1) mutational activation of Ha-ras and inactivation of p53 are unlikely to be involved in preneoplastic progression; (2) increased amounts of p53 protein may be involved in a subset of transformed cells, possibly reflecting a longer half-life, as demonstrated in other systems; and (3) late downregulation of p53 mRNA but not protein expression may be a secondary response in the TPA-mediated signal transduction pathway.	Tetradecanoylphorbol Acetate	430-433	tumor protein p53	Homo sapiens	192-195
8352882-7	1993	When MEK and HEK cultures were treated with TPA for 3 h, less than 30% of the control level of PKC activity was detected, indicating that TPA-induced downregulation of PKC was similar in MEKs and HEKs.	Tetradecanoylphorbol Acetate	44-47	mitogen-activated protein kinase kinase 7	Homo sapiens	5-8
8352891-9	1993	Both p53-hybridizing transcripts were downregulated by prolonged 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment (24 h) regardless of the stage of progression.	Tetradecanoylphorbol Acetate	65-101	tumor protein p53	Homo sapiens	5-8
7507222-2	1993	The tumor promoting phorbol ester TPA induced a marked up-regulation of protectin in all examined cell lines with the exception of promyelocytic leukemia HL-60, where TPA significantly decreased protectin cell surface expression.	Tetradecanoylphorbol Acetate	34-37	CD59 molecule (CD59 blood group)	Homo sapiens	72-81
7507222-2	1993	The tumor promoting phorbol ester TPA induced a marked up-regulation of protectin in all examined cell lines with the exception of promyelocytic leukemia HL-60, where TPA significantly decreased protectin cell surface expression.	Tetradecanoylphorbol Acetate	34-37	CD59 molecule (CD59 blood group)	Homo sapiens	195-204
7688870-3	1993	PMA-induced increase of the monocyte-associated CD14 antigen was dependent the presence of fetal bovine serum (FBS) in culture medium and partially abolished by calmodulin inhibitor R24571.	Tetradecanoylphorbol Acetate	0-3	calmodulin 1	Homo sapiens	161-171
7507222-2	1993	The tumor promoting phorbol ester TPA induced a marked up-regulation of protectin in all examined cell lines with the exception of promyelocytic leukemia HL-60, where TPA significantly decreased protectin cell surface expression.	Tetradecanoylphorbol Acetate	167-170	CD59 molecule (CD59 blood group)	Homo sapiens	195-204
8289985-4	1993	Calcitriol therapy resulted in significant increases in the phorbol myristate acetate (PMA)-induced secretion of IL-1 and IL-6 (p = 0.04 and 0.03, respectively).	Tetradecanoylphorbol Acetate	60-85	interleukin 6	Homo sapiens	122-126
8289985-4	1993	Calcitriol therapy resulted in significant increases in the phorbol myristate acetate (PMA)-induced secretion of IL-1 and IL-6 (p = 0.04 and 0.03, respectively).	Tetradecanoylphorbol Acetate	87-90	interleukin 6	Homo sapiens	122-126
8054705-7	1993	Phorbol-12-myristate-13-acetate increased the secretion of pro-cathepsin L in 6 of the non-small cell lung cancer cell lines.	Tetradecanoylphorbol Acetate	0-31	cathepsin L	Homo sapiens	63-74
8380916-5	1993	Prolonged treatment with TPA depleted cells of PKC-alpha but not of PKC-zeta.	Tetradecanoylphorbol Acetate	25-28	protein kinase C, alpha	Mus musculus	47-56
7678355-4	1993	Activation of PKC with phorbol myristate acetate (PMA) or mezerein upregulates VCAM-1 expression by TEC dose-dependently.	Tetradecanoylphorbol Acetate	23-48	vascular cell adhesion molecule 1	Homo sapiens	79-85
8396466-0	1993	Phorbol myristate acetate-differentiated THP-1 cells display increased levels of MHC class I and class II mRNA and interferon-gamma-inducible tumoricidal activity.	Tetradecanoylphorbol Acetate	0-25	GLI family zinc finger 2	Homo sapiens	41-46
8396466-0	1993	Phorbol myristate acetate-differentiated THP-1 cells display increased levels of MHC class I and class II mRNA and interferon-gamma-inducible tumoricidal activity.	Tetradecanoylphorbol Acetate	0-25	interferon gamma	Homo sapiens	115-131
8396466-1	1993	The protein kinase C activators phorbol 12-myristate 13-acetate (PMA) and mezerein induce differentiation of human monocytic leukemia (THP-1) cells along the monocyte/macrophage pathway of development.	Tetradecanoylphorbol Acetate	32-63	GLI family zinc finger 2	Homo sapiens	135-140
8396466-1	1993	The protein kinase C activators phorbol 12-myristate 13-acetate (PMA) and mezerein induce differentiation of human monocytic leukemia (THP-1) cells along the monocyte/macrophage pathway of development.	Tetradecanoylphorbol Acetate	65-68	GLI family zinc finger 2	Homo sapiens	135-140
8424125-6	1993	Like 12-O-Tetradecanoly phorbol-13-acetate (TPA), a PK-C activator which also enhances EGF-stimulated growth of MEC, linoleate can phosphorylate a 40-42 KD protein.	Tetradecanoylphorbol Acetate	44-47	proline rich transmembrane protein 2	Homo sapiens	52-56
8424125-6	1993	Like 12-O-Tetradecanoly phorbol-13-acetate (TPA), a PK-C activator which also enhances EGF-stimulated growth of MEC, linoleate can phosphorylate a 40-42 KD protein.	Tetradecanoylphorbol Acetate	44-47	C-C motif chemokine ligand 28	Homo sapiens	112-115
8356391-4	1993	Subcultured synovial fibroblasts, devoid of macrophages, did not produce MMP-9 as judged by zymography and immunolocalisation; but when stimulated with phorbol myristate acetate and interleukin-1 alpha both MMP-9 and MMP-3 were co-expressed.	Tetradecanoylphorbol Acetate	152-177	matrix metallopeptidase 3	Homo sapiens	217-222
8118227-5	1993	TNF-alpha, phorbol ester 12-myristate 13-acetate (PMA), and calcium ionophore (CI) A23817 all inhibited [125I]iodide transport, but high doses of PMA and CI also blocked the inhibitory action of TNF-alpha on [125I]iodide transport.	Tetradecanoylphorbol Acetate	146-149	tumor necrosis factor	Rattus norvegicus	195-204
7678355-4	1993	Activation of PKC with phorbol myristate acetate (PMA) or mezerein upregulates VCAM-1 expression by TEC dose-dependently.	Tetradecanoylphorbol Acetate	50-53	vascular cell adhesion molecule 1	Homo sapiens	79-85
1482376-5	1992	Incubation of Jurkat T cells (1 x 10(6) cells/ml) with a natural thiol antioxidant, alpha-lipoic acid, prior to the stimulation of cells was found to inhibit NF-kappa B activation induced by tumor necrosis factor-alpha (25 ng/ml) or by phorbol 12-myristate 13-acetate (50 ng/ml).	Tetradecanoylphorbol Acetate	236-267	nuclear factor kappa B subunit 1	Homo sapiens	158-168
1482376-5	1992	Incubation of Jurkat T cells (1 x 10(6) cells/ml) with a natural thiol antioxidant, alpha-lipoic acid, prior to the stimulation of cells was found to inhibit NF-kappa B activation induced by tumor necrosis factor-alpha (25 ng/ml) or by phorbol 12-myristate 13-acetate (50 ng/ml).	Tetradecanoylphorbol Acetate	236-267	tumor necrosis factor	Homo sapiens	191-218
1334056-1	1992	Squalene inhibited the effect of tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), such as increased 32Pi incorporation into phospholipids of HeLa cell membrane, induction of Epstein-Barr-virus early antigen in Raji cell and induction of ornithine decarboxylase in mouse skin.	Tetradecanoylphorbol Acetate	86-89	ornithine decarboxylase 1	Homo sapiens	247-270
1338571-3	1992	Treatment of the cells with the phorbol ester, tetradecanoyl phorbol acetate (TPA), resulted in both a loss of the heterogeneity of the pRB species and a significant decrease in the level of pRB phosphorylation.	Tetradecanoylphorbol Acetate	47-76	RB transcriptional corepressor 1	Homo sapiens	136-139
1338571-3	1992	Treatment of the cells with the phorbol ester, tetradecanoyl phorbol acetate (TPA), resulted in both a loss of the heterogeneity of the pRB species and a significant decrease in the level of pRB phosphorylation.	Tetradecanoylphorbol Acetate	47-76	RB transcriptional corepressor 1	Homo sapiens	191-194
1332693-4	1992	Addition of ionomycin in Ca(2+)-containing buffer did not cause a rise in basal pHi; however, addition of the phorbol ester phorbol 12-myristate 13-acetate (PMA) did cause a slowly developing rise in resting pHi of 0.14 +/- 0.02 unit over 4-5 min.	Tetradecanoylphorbol Acetate	124-155	glucose-6-phosphate isomerase	Homo sapiens	208-211
1338571-3	1992	Treatment of the cells with the phorbol ester, tetradecanoyl phorbol acetate (TPA), resulted in both a loss of the heterogeneity of the pRB species and a significant decrease in the level of pRB phosphorylation.	Tetradecanoylphorbol Acetate	78-81	RB transcriptional corepressor 1	Homo sapiens	136-139
1338571-3	1992	Treatment of the cells with the phorbol ester, tetradecanoyl phorbol acetate (TPA), resulted in both a loss of the heterogeneity of the pRB species and a significant decrease in the level of pRB phosphorylation.	Tetradecanoylphorbol Acetate	78-81	RB transcriptional corepressor 1	Homo sapiens	191-194
1338571-6	1992	These results are consistent with a model in which TPA and dibutyryl cAMP dependent pathways can activate pRB by altering its phosphorylation.	Tetradecanoylphorbol Acetate	51-54	RB transcriptional corepressor 1	Homo sapiens	106-109
1332693-4	1992	Addition of ionomycin in Ca(2+)-containing buffer did not cause a rise in basal pHi; however, addition of the phorbol ester phorbol 12-myristate 13-acetate (PMA) did cause a slowly developing rise in resting pHi of 0.14 +/- 0.02 unit over 4-5 min.	Tetradecanoylphorbol Acetate	157-160	glucose-6-phosphate isomerase	Homo sapiens	208-211
1472061-6	1992	Osteopontin synthesis markedly increased by 12-O-tetradecanoylphorbol-13-acetate (TPA) as observed in many osteoblastic cells.	Tetradecanoylphorbol Acetate	44-80	secreted phosphoprotein 1	Rattus norvegicus	0-11
1472895-4	1992	The PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA) suppressed IGF-I secretion in a dose-dependent manner.	Tetradecanoylphorbol Acetate	19-55	insulin-like growth factor 1	Mus musculus	73-78
1472061-6	1992	Osteopontin synthesis markedly increased by 12-O-tetradecanoylphorbol-13-acetate (TPA) as observed in many osteoblastic cells.	Tetradecanoylphorbol Acetate	82-85	secreted phosphoprotein 1	Rattus norvegicus	0-11
1332693-6	1992	In nigericin-pretreated cells, PMA caused a rapid rise in pHi without changing the [Ca2+]i.	Tetradecanoylphorbol Acetate	31-34	glucose-6-phosphate isomerase	Homo sapiens	58-61
1472895-4	1992	The PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA) suppressed IGF-I secretion in a dose-dependent manner.	Tetradecanoylphorbol Acetate	57-60	insulin-like growth factor 1	Mus musculus	73-78
1394183-7	1992	PKC-epsilon displayed a similar sensitivity to TPA-induced down-regulation as did PKC-beta while PKC-alpha was more resistant to this effect.	Tetradecanoylphorbol Acetate	47-50	protein kinase C beta	Homo sapiens	82-90
1472895-10	1992	Exogenous IGF-I recovered the inhibitory effect of TPA on 45Ca-accumulation.	Tetradecanoylphorbol Acetate	51-54	insulin-like growth factor 1	Mus musculus	10-15
1359972-1	1992	In the present article we show that supernatants derived from lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA)-stimulated A-20 B cell lymphoma are able to induce polyclonal immunoglobulin (Ig) secretion by normal B cells in a T-cell-dependent manner.	Tetradecanoylphorbol Acetate	90-121	TNF alpha induced protein 3	Homo sapiens	139-143
1359972-1	1992	In the present article we show that supernatants derived from lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA)-stimulated A-20 B cell lymphoma are able to induce polyclonal immunoglobulin (Ig) secretion by normal B cells in a T-cell-dependent manner.	Tetradecanoylphorbol Acetate	123-126	TNF alpha induced protein 3	Homo sapiens	139-143
1460022-10	1992	However, unlike other neutrophil secondary granule genes, HNG mRNA was detected in HL60 cells induced to monocytic maturation with 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	131-167	neurogranin	Homo sapiens	58-61
1493921-2	1992	IL-5 expression was stimulated by phytohaemagglutinin (PHA), IL-2, phorbol myristate acetate (PMA) or Ionomycin.	Tetradecanoylphorbol Acetate	67-92	interleukin 5	Homo sapiens	0-4
1493921-2	1992	IL-5 expression was stimulated by phytohaemagglutinin (PHA), IL-2, phorbol myristate acetate (PMA) or Ionomycin.	Tetradecanoylphorbol Acetate	94-97	interleukin 5	Homo sapiens	0-4
1493921-5	1992	Dexamethasone at 10(-6) M also profoundly inhibited the IL-5 response to PMA and to IL-2, but the IL-5 response to Ionomycin was not significantly affected.	Tetradecanoylphorbol Acetate	73-76	interleukin 5	Homo sapiens	56-60
1445798-4	1992	junB and fosB were rapidly induced following stimulation with TPA.	Tetradecanoylphorbol Acetate	62-65	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	9-13
1477186-2	1992	The suppressive effect of beta-endorphin is not exercised through a cAMP-dependent mechanism and is also observed when splenic lymphocytes are stimulated with phytohemagglutinin (4 micrograms/ml), anti-CD3 monoclonal antibody, or the Ca2+ ionophore A23187 (250 nM) and phorbol 12-myristate 13-acetate (1 ng/ml).	Tetradecanoylphorbol Acetate	269-300	pro-opiomelanocortin-alpha	Mus musculus	26-40
1445798-6	1992	The expression of fos and jun during T-cell activation was accompanied by increased specific binding of JunB, FosB, and fos-related antigen containing complexes to the TPA responsive element.	Tetradecanoylphorbol Acetate	168-171	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	110-114
1445803-7	1992	These results suggest that the signal transduction pathway that leads to PMA-induced differentiation in the HL-60 cell system requires PKC-beta and/or delta-like PKC for the proper expression of the early response genes, and ultimately the expression of genes that define the mature state.	Tetradecanoylphorbol Acetate	73-76	protein kinase C beta	Homo sapiens	135-143
1405765-5	1992	A third antibody, EOS47, recognizes a 100 kDa molecule that is expressed on the surface of TPA-induced peroxidase positive cells (an enzyme that in avian species is restricted to cells of the eosinophilic lineage).	Tetradecanoylphorbol Acetate	91-94	melanotransferrin	Gallus gallus	18-23
1283312-0	1992	Differential phosphorylation of CK8 and CK18 by 12-O-tetradecanoyl-phorbol-13-acetate in primary cultures of mouse hepatocytes.	Tetradecanoylphorbol Acetate	48-85	keratin 18	Mus musculus	40-44
1283312-3	1992	Treatment of the hepatocytes with 150 nM 12-O-tetradecanoyl-phorbol-13-acetate (TPA) an activator of protein kinase C induced a transient increase in the level of phosphorylation of CK8 but not CK18.	Tetradecanoylphorbol Acetate	41-78	keratin 18	Mus musculus	194-198
1283312-3	1992	Treatment of the hepatocytes with 150 nM 12-O-tetradecanoyl-phorbol-13-acetate (TPA) an activator of protein kinase C induced a transient increase in the level of phosphorylation of CK8 but not CK18.	Tetradecanoylphorbol Acetate	80-83	keratin 18	Mus musculus	194-198
1281302-4	1992	Transcriptional activation of the c-jun, junB and c-fos genes following TPA/serum induction was unaffected and efficient transactivation of AP-1 reporter constructs was demonstrated in these cells.	Tetradecanoylphorbol Acetate	72-75	jun proto-oncogene	Mus musculus	34-39
1290964-3	1992	We found that GM-CSFR beta-subunit mRNA was expressed constitutively in CMK cells and was transiently down-regulated by TPA and IL-6, while the expression of IL-6R mRNA was increased by TPA in association with the differentiation of megakaryocytes.	Tetradecanoylphorbol Acetate	120-123	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	14-21
1290964-3	1992	We found that GM-CSFR beta-subunit mRNA was expressed constitutively in CMK cells and was transiently down-regulated by TPA and IL-6, while the expression of IL-6R mRNA was increased by TPA in association with the differentiation of megakaryocytes.	Tetradecanoylphorbol Acetate	186-189	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	14-21
1423659-4	1992	Phorbol 12-myristate 13-acetate-induced secretion of hHGF from human skin fibroblasts was also suppressed by TGF-beta 1.	Tetradecanoylphorbol Acetate	0-31	hepatocyte growth factor	Homo sapiens	53-57
1290964-4	1992	Furthermore, the TPA-induced down-regulation of GM-CSFR beta-subunit mRNA expression and its recovery were blocked by cycloheximide (CHX), a protein synthesis inhibitor, suggesting that these modulations required de novo protein synthesis.	Tetradecanoylphorbol Acetate	17-20	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	48-55
1362194-10	1992	Monocytic differentiation of the myeloid cell line HL60 by 12-O-tetradecanoylphorbol-13-acetate (TPA) was accompanied by a decrease in reactivity with the antibodies, which could be reversed by neuraminidase digestion.	Tetradecanoylphorbol Acetate	59-95	neuraminidase 1	Homo sapiens	194-207
1362194-10	1992	Monocytic differentiation of the myeloid cell line HL60 by 12-O-tetradecanoylphorbol-13-acetate (TPA) was accompanied by a decrease in reactivity with the antibodies, which could be reversed by neuraminidase digestion.	Tetradecanoylphorbol Acetate	97-100	neuraminidase 1	Homo sapiens	194-207
1326682-5	1992	Superoxide anion (O2-) release by macrophages in response to phorbol myristate acetate was determined by cytochrome c reduction.	Tetradecanoylphorbol Acetate	61-86	cytochrome c	Oryctolagus cuniculus	105-117
1459865-3	1992	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) to link LFA-1 molecules to the cytoskeleton increased the percentage of capped cells, implying a faster and more efficient process of capping.	Tetradecanoylphorbol Acetate	15-51	integrin subunit alpha L	Homo sapiens	66-71
1459865-3	1992	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) to link LFA-1 molecules to the cytoskeleton increased the percentage of capped cells, implying a faster and more efficient process of capping.	Tetradecanoylphorbol Acetate	53-56	integrin subunit alpha L	Homo sapiens	66-71
1437148-4	1992	The tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) is one of the agents able to induce this hyperphosphorylation of Raf in vivo, suggesting that protein kinase C (PKC) may be involved in the activation of c-Raf in particular situations.	Tetradecanoylphorbol Acetate	19-56	zinc fingers and homeoboxes 2	Homo sapiens	128-131
1437148-4	1992	The tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) is one of the agents able to induce this hyperphosphorylation of Raf in vivo, suggesting that protein kinase C (PKC) may be involved in the activation of c-Raf in particular situations.	Tetradecanoylphorbol Acetate	19-56	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	217-222
1437148-4	1992	The tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) is one of the agents able to induce this hyperphosphorylation of Raf in vivo, suggesting that protein kinase C (PKC) may be involved in the activation of c-Raf in particular situations.	Tetradecanoylphorbol Acetate	58-61	zinc fingers and homeoboxes 2	Homo sapiens	128-131
1437148-4	1992	The tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) is one of the agents able to induce this hyperphosphorylation of Raf in vivo, suggesting that protein kinase C (PKC) may be involved in the activation of c-Raf in particular situations.	Tetradecanoylphorbol Acetate	58-61	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	217-222
1437148-6	1992	Direct phosphorylation of the Raf protein with PKC in vitro also enhanced the kinase activity of c-Raf, suggesting that c-Raf acts immediately downstream of PKC in a protein kinase cascade which is triggered by TPA and may lead to transcriptional activation of TPA-inducible genes and tumor promotion.	Tetradecanoylphorbol Acetate	211-214	zinc fingers and homeoboxes 2	Homo sapiens	30-33
1437148-6	1992	Direct phosphorylation of the Raf protein with PKC in vitro also enhanced the kinase activity of c-Raf, suggesting that c-Raf acts immediately downstream of PKC in a protein kinase cascade which is triggered by TPA and may lead to transcriptional activation of TPA-inducible genes and tumor promotion.	Tetradecanoylphorbol Acetate	211-214	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	97-102
1437148-6	1992	Direct phosphorylation of the Raf protein with PKC in vitro also enhanced the kinase activity of c-Raf, suggesting that c-Raf acts immediately downstream of PKC in a protein kinase cascade which is triggered by TPA and may lead to transcriptional activation of TPA-inducible genes and tumor promotion.	Tetradecanoylphorbol Acetate	211-214	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	120-125
1437148-6	1992	Direct phosphorylation of the Raf protein with PKC in vitro also enhanced the kinase activity of c-Raf, suggesting that c-Raf acts immediately downstream of PKC in a protein kinase cascade which is triggered by TPA and may lead to transcriptional activation of TPA-inducible genes and tumor promotion.	Tetradecanoylphorbol Acetate	261-264	zinc fingers and homeoboxes 2	Homo sapiens	30-33
1406718-1	1992	The cell surface expression of the CD32 receptors for the Fc portion of immunoglobulin G (Fc gamma RII) is highly regulated by agents such as phorbol ester (PMA) and cytokines.	Tetradecanoylphorbol Acetate	157-160	Fc gamma receptor IIa	Homo sapiens	35-39
1400499-0	1992	Distal AP-1 binding sites mediate basal level enhancement and TPA induction of the mouse heme oxygenase-1 gene.	Tetradecanoylphorbol Acetate	62-65	jun proto-oncogene	Mus musculus	7-11
1618787-10	1992	Treatment of R6 cells with 12-O-tetradecanoyl phorbol 13-acetate (TPA), resulted in the translocation of all four PKC isozymes to the membrane fraction, and the subsequent down-regulation of cPKC alpha, nPKC zeta, and nPKC delta, nPKC epsilon, however, was only partially down-regulated in response to long-term TPA exposure.	Tetradecanoylphorbol Acetate	27-64	protein kinase C, delta	Rattus norvegicus	114-117
1400499-7	1992	These functions are mediated by the AP-1 binding sites as multiple copies of the region A motif also confer TPA induction and c-Jun/c-Fos transactivation upon a heterologous promoter.	Tetradecanoylphorbol Acetate	108-111	jun proto-oncogene	Mus musculus	36-40
1384479-5	1992	The tumor promoter, tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the stimulatory effect of IL-1 alpha and IL-1 beta on the production of HGF.	Tetradecanoylphorbol Acetate	53-56	hepatocyte growth factor	Homo sapiens	148-151
1437148-6	1992	Direct phosphorylation of the Raf protein with PKC in vitro also enhanced the kinase activity of c-Raf, suggesting that c-Raf acts immediately downstream of PKC in a protein kinase cascade which is triggered by TPA and may lead to transcriptional activation of TPA-inducible genes and tumor promotion.	Tetradecanoylphorbol Acetate	261-264	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	97-102
1437148-6	1992	Direct phosphorylation of the Raf protein with PKC in vitro also enhanced the kinase activity of c-Raf, suggesting that c-Raf acts immediately downstream of PKC in a protein kinase cascade which is triggered by TPA and may lead to transcriptional activation of TPA-inducible genes and tumor promotion.	Tetradecanoylphorbol Acetate	261-264	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	120-125
1618787-10	1992	Treatment of R6 cells with 12-O-tetradecanoyl phorbol 13-acetate (TPA), resulted in the translocation of all four PKC isozymes to the membrane fraction, and the subsequent down-regulation of cPKC alpha, nPKC zeta, and nPKC delta, nPKC epsilon, however, was only partially down-regulated in response to long-term TPA exposure.	Tetradecanoylphorbol Acetate	27-64	protein kinase C, zeta	Rattus norvegicus	203-212
1282723-1	1992	ICAM-1 expression in TEC is stimulated with phorbol 12-myristate 13-acetate (PMA), but not with forskolin, suggesting a role for protein kinase C (PKC) but not for protein kinase A (PKA).	Tetradecanoylphorbol Acetate	44-75	intercellular adhesion molecule 1	Mus musculus	0-6
1618787-10	1992	Treatment of R6 cells with 12-O-tetradecanoyl phorbol 13-acetate (TPA), resulted in the translocation of all four PKC isozymes to the membrane fraction, and the subsequent down-regulation of cPKC alpha, nPKC zeta, and nPKC delta, nPKC epsilon, however, was only partially down-regulated in response to long-term TPA exposure.	Tetradecanoylphorbol Acetate	27-64	protein kinase C, delta	Rattus norvegicus	218-228
1282723-1	1992	ICAM-1 expression in TEC is stimulated with phorbol 12-myristate 13-acetate (PMA), but not with forskolin, suggesting a role for protein kinase C (PKC) but not for protein kinase A (PKA).	Tetradecanoylphorbol Acetate	77-80	intercellular adhesion molecule 1	Mus musculus	0-6
1331679-5	1992	The GLUT1 mRNA level was increased by exposure to 12-O-tetra-decanoyl-phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	90-93	solute carrier family 2 member 1	Bos taurus	4-9
1282723-3	1992	The TNF-alpha-stimulated ICAM-1 expression is resistant however to downregulation of PKC with PMA.	Tetradecanoylphorbol Acetate	94-97	intercellular adhesion molecule 1	Mus musculus	25-31
1618787-10	1992	Treatment of R6 cells with 12-O-tetradecanoyl phorbol 13-acetate (TPA), resulted in the translocation of all four PKC isozymes to the membrane fraction, and the subsequent down-regulation of cPKC alpha, nPKC zeta, and nPKC delta, nPKC epsilon, however, was only partially down-regulated in response to long-term TPA exposure.	Tetradecanoylphorbol Acetate	66-69	protein kinase C, delta	Rattus norvegicus	114-117
1331679-6	1992	Both serum and TPA enhanced cytoplasmic actin and beta-tubulin mRNA levels in cultured cells; the serum effect on cytoskeletal mRNA persisted through at least 24 h of exposure whereas the TPA stimulation was maximal by 2 h of exposure and lost following 8 h. Both serum and TPA increased cytoplasmic actin mRNA levels approximately 2- to 3-fold greater than the increase in beta-tubulin mRNA levels.	Tetradecanoylphorbol Acetate	15-18	actin epsilon 1	Bos taurus	40-45
1331679-6	1992	Both serum and TPA enhanced cytoplasmic actin and beta-tubulin mRNA levels in cultured cells; the serum effect on cytoskeletal mRNA persisted through at least 24 h of exposure whereas the TPA stimulation was maximal by 2 h of exposure and lost following 8 h. Both serum and TPA increased cytoplasmic actin mRNA levels approximately 2- to 3-fold greater than the increase in beta-tubulin mRNA levels.	Tetradecanoylphorbol Acetate	15-18	actin epsilon 1	Bos taurus	300-305
1400474-7	1992	Differential substrate phosphorylation by PS/PMA also occurred for PKC isozymes resolved by hydroxylapatite chromatography and was most dramatic for PKC-alpha, which could no longer phosphorylate histone or GS1-12.	Tetradecanoylphorbol Acetate	45-48	pseudouridine 5'-phosphatase	Homo sapiens	207-213
1618787-10	1992	Treatment of R6 cells with 12-O-tetradecanoyl phorbol 13-acetate (TPA), resulted in the translocation of all four PKC isozymes to the membrane fraction, and the subsequent down-regulation of cPKC alpha, nPKC zeta, and nPKC delta, nPKC epsilon, however, was only partially down-regulated in response to long-term TPA exposure.	Tetradecanoylphorbol Acetate	66-69	protein kinase C, zeta	Rattus norvegicus	203-212
1400474-8	1992	Differential activities of PKC were also observed in synaptosol and in intact synaptosomes where PMA stimulated phosphorylation of MARCKS, but not dephosphin.	Tetradecanoylphorbol Acetate	97-100	myristoylated alanine rich protein kinase C substrate	Homo sapiens	131-137
1331679-6	1992	Both serum and TPA enhanced cytoplasmic actin and beta-tubulin mRNA levels in cultured cells; the serum effect on cytoskeletal mRNA persisted through at least 24 h of exposure whereas the TPA stimulation was maximal by 2 h of exposure and lost following 8 h. Both serum and TPA increased cytoplasmic actin mRNA levels approximately 2- to 3-fold greater than the increase in beta-tubulin mRNA levels.	Tetradecanoylphorbol Acetate	188-191	actin epsilon 1	Bos taurus	300-305
1331679-6	1992	Both serum and TPA enhanced cytoplasmic actin and beta-tubulin mRNA levels in cultured cells; the serum effect on cytoskeletal mRNA persisted through at least 24 h of exposure whereas the TPA stimulation was maximal by 2 h of exposure and lost following 8 h. Both serum and TPA increased cytoplasmic actin mRNA levels approximately 2- to 3-fold greater than the increase in beta-tubulin mRNA levels.	Tetradecanoylphorbol Acetate	188-191	actin epsilon 1	Bos taurus	300-305
1618787-10	1992	Treatment of R6 cells with 12-O-tetradecanoyl phorbol 13-acetate (TPA), resulted in the translocation of all four PKC isozymes to the membrane fraction, and the subsequent down-regulation of cPKC alpha, nPKC zeta, and nPKC delta, nPKC epsilon, however, was only partially down-regulated in response to long-term TPA exposure.	Tetradecanoylphorbol Acetate	66-69	protein kinase C, delta	Rattus norvegicus	218-228
1356818-0	1992	Regulation of transglutaminase 1 gene expression by 12-O-tetradecanoylphorbol-13-acetate, dexamethasone, and retinoic acid in cultured human keratinocytes.	Tetradecanoylphorbol Acetate	52-88	transglutaminase 1	Homo sapiens	14-32
1622389-1	1992	A possible role for protein kinase C. Several agonists of endothelial cell function (thrombin, histamine, dioctanoylglycerol, phorbol 12-myristate 13-acetate, interleukin-1) have previously been shown to enhance the level of phosphorylation of an undefined 29,000-M(r) protein (P29).	Tetradecanoylphorbol Acetate	126-157	SYF2 pre-mRNA splicing factor	Homo sapiens	278-281
1356818-3	1992	Treatment of NHEK with TPA, up to 10 nM, markedly increased the levels of TG1 mRNA in a dose-dependent manner.	Tetradecanoylphorbol Acetate	23-26	transglutaminase 1	Homo sapiens	74-77
1356818-6	1992	The induction of TG1 mRNA expression by TPA was inhibited by 1-(5-isoquinolinylsulfonyl)-2-methyl-piperazine (H-7) and staurosporine.	Tetradecanoylphorbol Acetate	40-43	transglutaminase 1	Homo sapiens	17-20
1356818-9	1992	Moreover, 1 microM of retinoic acid completely inhibited the induction of TG1 mRNA by both TPA and dexamethasone.	Tetradecanoylphorbol Acetate	91-94	transglutaminase 1	Homo sapiens	74-77
1394441-3	1992	After stimulation with phytohemagglutinin (PHA) and phorbol myristate acetate (PMA), Tat transfectants with high Tat expression showed diminished expression of interleukin-2 (IL-2) and the interleukin-2 receptor alpha chain (IL-2R) when compared to untransfected Jurkat cells or Jurkat cell lines transfected with the parent control plasmid.	Tetradecanoylphorbol Acetate	52-77	tyrosine aminotransferase	Homo sapiens	85-88
1394441-3	1992	After stimulation with phytohemagglutinin (PHA) and phorbol myristate acetate (PMA), Tat transfectants with high Tat expression showed diminished expression of interleukin-2 (IL-2) and the interleukin-2 receptor alpha chain (IL-2R) when compared to untransfected Jurkat cells or Jurkat cell lines transfected with the parent control plasmid.	Tetradecanoylphorbol Acetate	52-77	tyrosine aminotransferase	Homo sapiens	113-116
1394441-3	1992	After stimulation with phytohemagglutinin (PHA) and phorbol myristate acetate (PMA), Tat transfectants with high Tat expression showed diminished expression of interleukin-2 (IL-2) and the interleukin-2 receptor alpha chain (IL-2R) when compared to untransfected Jurkat cells or Jurkat cell lines transfected with the parent control plasmid.	Tetradecanoylphorbol Acetate	52-77	interleukin 2 receptor subunit alpha	Homo sapiens	225-230
1354412-4	1992	TPA treatment induced the coexpression of CD22 (mean 49%) and CD11c (mean 48%) and tartrate-resistant acid phosphatase in seven of eight cases.	Tetradecanoylphorbol Acetate	0-3	integrin subunit alpha X	Homo sapiens	62-67
1616052-4	1992	Inhibitory effects of both agents on SP-A gene transcription were readily detected within 6 h after exposure and persisted for 24 h. While TNF-alpha and TPA decreased cellular SP-B mRNA content, transcription of the SP-B gene was not influenced by these agents.	Tetradecanoylphorbol Acetate	153-156	surfactant protein A1	Homo sapiens	37-41
1421058-5	1992	It is known that the secretion of TGF-alpha may be enhanced appreciably by agents such as phorbol 12-myristate 13-acetate (PMA), serum factors and epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	90-121	transforming growth factor alpha	Homo sapiens	34-43
1421058-5	1992	It is known that the secretion of TGF-alpha may be enhanced appreciably by agents such as phorbol 12-myristate 13-acetate (PMA), serum factors and epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	123-126	transforming growth factor alpha	Homo sapiens	34-43
1406637-2	1992	In addition, phorbol esters may promote cell growth by the inhibition of expression of cellular gene products regulated by antiproliferative agents such as interferons (IFN)s. In human diploid fibroblasts, phorbol 12-myristate 13-acetate (PMA) selectively inhibits the IFN-alpha-induced cellular gene ISG54.	Tetradecanoylphorbol Acetate	206-237	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	301-306
1616052-4	1992	Inhibitory effects of both agents on SP-A gene transcription were readily detected within 6 h after exposure and persisted for 24 h. While TNF-alpha and TPA decreased cellular SP-B mRNA content, transcription of the SP-B gene was not influenced by these agents.	Tetradecanoylphorbol Acetate	153-156	surfactant protein B	Homo sapiens	176-180
1358016-5	1992	Neutrophils from 12 cows or bulls exposed to phorbol myristate acetate in vitro increased expression of CD18 by 137 +/- 37% (P = 0.0035).	Tetradecanoylphorbol Acetate	45-70	integrin subunit beta 2	Bos taurus	104-108
1616052-5	1992	In contrast to the inhibitory effects of TPA and TNF-alpha on SP-A and SP-B mRNAs, steady-state mRNA and rate of transcription of human manganese superoxide dismutase (MnSOD) were increased by both agents.	Tetradecanoylphorbol Acetate	41-44	surfactant protein A1	Homo sapiens	62-66
1390239-10	1992	The expression of CD7 remarkably was depressed, while that of CD13 was enhanced after culture with TPA.	Tetradecanoylphorbol Acetate	99-102	alanyl aminopeptidase, membrane	Homo sapiens	62-66
1616052-5	1992	In contrast to the inhibitory effects of TPA and TNF-alpha on SP-A and SP-B mRNAs, steady-state mRNA and rate of transcription of human manganese superoxide dismutase (MnSOD) were increased by both agents.	Tetradecanoylphorbol Acetate	41-44	surfactant protein B	Homo sapiens	71-75
1616052-6	1992	The time course and extent of increased MnSOD gene transcription by TNF-alpha and TPA were distinct.	Tetradecanoylphorbol Acetate	82-85	superoxide dismutase 2	Homo sapiens	40-45
1616052-8	1992	The inhibitory effects of TPA and TNF-alpha on SP-A expression in pulmonary adenocarcinoma cells are associated with the inhibition of SP-A gene transcription.	Tetradecanoylphorbol Acetate	26-29	surfactant protein A1	Homo sapiens	47-51
1355014-1	1992	The effects of several cytokines and phorbol myristate acetate (PMA) on LFA-1 and ICAM-1 expression on a human eosinophilic leukemia cell line, EoL-3, were investigated and compared with those of a human monocytic leukemia cell line, U937.	Tetradecanoylphorbol Acetate	64-67	integrin subunit alpha L	Homo sapiens	72-77
1616052-8	1992	The inhibitory effects of TPA and TNF-alpha on SP-A expression in pulmonary adenocarcinoma cells are associated with the inhibition of SP-A gene transcription.	Tetradecanoylphorbol Acetate	26-29	surfactant protein A1	Homo sapiens	135-139
1378868-11	1992	To examine whether, independent of the protection against LPS, G-CSF treatment still activated neutrophils, it was demonstrated that granulocytes from G-CSF-treated rats were primed for PMA-induced oxidative burst and for ionophore/arachidonic acid-stimulated lipoxygenase product formation.	Tetradecanoylphorbol Acetate	186-189	colony stimulating factor 3	Rattus norvegicus	63-68
1378868-11	1992	To examine whether, independent of the protection against LPS, G-CSF treatment still activated neutrophils, it was demonstrated that granulocytes from G-CSF-treated rats were primed for PMA-induced oxidative burst and for ionophore/arachidonic acid-stimulated lipoxygenase product formation.	Tetradecanoylphorbol Acetate	186-189	colony stimulating factor 3	Rattus norvegicus	151-156
1323434-2	1992	Phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate also increased the MBP kinase activity.	Tetradecanoylphorbol Acetate	0-31	myelin basic protein	Homo sapiens	86-89
1616052-10	1992	Actinomycin D blocked the inhibitory effects of TNF-alpha and TPA on SP-A and SP-B mRNA, supporting a role for posttranscriptional events in the modulation of the expression of the surfactant proteins SP-A and SP-B.	Tetradecanoylphorbol Acetate	62-65	surfactant protein A1	Homo sapiens	69-73
1618855-3	1992	The F52 protein was expressed in Escherichia coli with apparent M(r) 50,000; it was a substrate for PKC and comigrated on two-dimensional electrophoresis with a myristoylated protein whose phosphorylation was stimulated by phorbol 12-myristate 13-acetate in mouse neuroblastoma cells.	Tetradecanoylphorbol Acetate	223-254	MARCKS-like 1	Mus musculus	4-7
1616052-10	1992	Actinomycin D blocked the inhibitory effects of TNF-alpha and TPA on SP-A and SP-B mRNA, supporting a role for posttranscriptional events in the modulation of the expression of the surfactant proteins SP-A and SP-B.	Tetradecanoylphorbol Acetate	62-65	surfactant protein B	Homo sapiens	78-82
1388136-3	1992	TPA-induced T-cell proliferation, expression of interleukin-2 receptor-alpha subunit (IL-2R alpha) and transferrin receptor, CD3 down-regulation and, lastly, the cytosol-to-membrane PKC translocation (determined by an enzymatic assay or by immunoblotting with a cross-reactive anti-PKC peptide antibody) were all facilitated by ionomycin.	Tetradecanoylphorbol Acetate	0-3	interleukin 2 receptor subunit alpha	Homo sapiens	86-97
1616052-10	1992	Actinomycin D blocked the inhibitory effects of TNF-alpha and TPA on SP-A and SP-B mRNA, supporting a role for posttranscriptional events in the modulation of the expression of the surfactant proteins SP-A and SP-B.	Tetradecanoylphorbol Acetate	62-65	surfactant protein A1	Homo sapiens	201-205
1388136-4	1992	Immunoblots with isoenzyme-specific anti-PKC monoclonal antibodies demonstrated expression of immunoreactive PKC alpha, PKC beta and PKC gamma proteins that were translocated to the membrane upon TPA plus ionomycin stimulation.	Tetradecanoylphorbol Acetate	196-199	protein kinase C beta	Homo sapiens	120-128
1388136-6	1992	TPA increased by two- to threefold the expression of PKC beta, but not of PKC alpha or PKC gamma, mRNA within 12 hr of stimulation.	Tetradecanoylphorbol Acetate	0-3	protein kinase C beta	Homo sapiens	53-61
1323434-2	1992	Phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate also increased the MBP kinase activity.	Tetradecanoylphorbol Acetate	33-36	myelin basic protein	Homo sapiens	86-89
1616052-10	1992	Actinomycin D blocked the inhibitory effects of TNF-alpha and TPA on SP-A and SP-B mRNA, supporting a role for posttranscriptional events in the modulation of the expression of the surfactant proteins SP-A and SP-B.	Tetradecanoylphorbol Acetate	62-65	surfactant protein B	Homo sapiens	210-214
1388136-7	1992	Ionomycin synergized with TPA in increasing the expression of PKC alpha and PKC beta mRNA.	Tetradecanoylphorbol Acetate	26-29	protein kinase C beta	Homo sapiens	76-84
1586720-5	1992	When induced toward the mononuclear phagocytic lineage with phorbol 12-myristate 13-acetate (PMA), HL-60 cells exhibited marked suppression of NE gene transcription, declining to 17% of the resting rate within 2 days.	Tetradecanoylphorbol Acetate	60-91	elastase, neutrophil expressed	Homo sapiens	143-145
1618788-7	1992	Furthermore, we demonstrated that overproduction of an exogenous cPKC beta I isoform in these cells (R6-PKC3) altered the TPA-induced down-regulation of nPKC delta and nPKC epsilon.	Tetradecanoylphorbol Acetate	122-125	protein kinase C, delta	Rattus norvegicus	153-163
1616052-1	1992	Tumor necrosis factor-alpha (TNF-alpha) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) decrease the synthesis of surfactant proteins association with decreased SP-A and SP-B mRNA.	Tetradecanoylphorbol Acetate	63-100	surfactant protein A1	Homo sapiens	180-184
1616052-1	1992	Tumor necrosis factor-alpha (TNF-alpha) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) decrease the synthesis of surfactant proteins association with decreased SP-A and SP-B mRNA.	Tetradecanoylphorbol Acetate	63-100	surfactant protein B	Homo sapiens	189-193
1616052-1	1992	Tumor necrosis factor-alpha (TNF-alpha) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) decrease the synthesis of surfactant proteins association with decreased SP-A and SP-B mRNA.	Tetradecanoylphorbol Acetate	102-105	surfactant protein A1	Homo sapiens	180-184
1616052-1	1992	Tumor necrosis factor-alpha (TNF-alpha) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) decrease the synthesis of surfactant proteins association with decreased SP-A and SP-B mRNA.	Tetradecanoylphorbol Acetate	102-105	surfactant protein B	Homo sapiens	189-193
1616052-3	1992	SP-A gene transcription was inhibited by both TNF-alpha and TPA as assessed by nuclear run-on assays.	Tetradecanoylphorbol Acetate	60-63	surfactant protein A1	Homo sapiens	0-4
1331038-6	1992	Treatment of quiescent C2 cells with a tumor promoter, 12-O-tetradecanoylphorbol 13-acetate, transiently induced c-jun and c-fos mRNAs, and temporarily deinduced myoD and myogenin mRNAs just after the expression of the protooncogenes.	Tetradecanoylphorbol Acetate	55-91	jun proto-oncogene	Mus musculus	113-118
1434953-3	1992	PP T cells from aged mice responded synergistically to a protein kinase C (PKC) activator, phorbol myristate acetate (PHA), plus a calcium ionophore, ionomycin, at much lower concentrations than to Con A (P &lt; 0.001); however, the maximal proliferative response still remained nearly at 8/10th of the young (P &lt; 0.01) and higher levels of PMA (but not of ionomycin) were required (P &lt; 0.001).	Tetradecanoylphorbol Acetate	91-116	protein phosphatase 5, catalytic subunit	Mus musculus	0-4
1586720-5	1992	When induced toward the mononuclear phagocytic lineage with phorbol 12-myristate 13-acetate (PMA), HL-60 cells exhibited marked suppression of NE gene transcription, declining to 17% of the resting rate within 2 days.	Tetradecanoylphorbol Acetate	93-96	elastase, neutrophil expressed	Homo sapiens	143-145
1434953-3	1992	PP T cells from aged mice responded synergistically to a protein kinase C (PKC) activator, phorbol myristate acetate (PHA), plus a calcium ionophore, ionomycin, at much lower concentrations than to Con A (P &lt; 0.001); however, the maximal proliferative response still remained nearly at 8/10th of the young (P &lt; 0.01) and higher levels of PMA (but not of ionomycin) were required (P &lt; 0.001).	Tetradecanoylphorbol Acetate	344-347	protein phosphatase 5, catalytic subunit	Mus musculus	0-4
1350981-5	1992	In contrast, CD4+ T cells produced IL-2 when cultured with CD8+ CHO cells and co-stimulated with phorbol myristate acetate (PMA) or mAb to CD3 or CD28.	Tetradecanoylphorbol Acetate	97-122	interleukin-2	Cricetulus griseus	35-39
1320458-6	1992	6 h treatment with PMA induced down-regulation of PKC beta, whereas longer treatment was needed for down-regulation of PKC alpha.	Tetradecanoylphorbol Acetate	19-22	protein kinase C, beta	Mus musculus	50-58
1350981-5	1992	In contrast, CD4+ T cells produced IL-2 when cultured with CD8+ CHO cells and co-stimulated with phorbol myristate acetate (PMA) or mAb to CD3 or CD28.	Tetradecanoylphorbol Acetate	124-127	interleukin-2	Cricetulus griseus	35-39
1643643-4	1992	Dose-response studies revealed that the most effective TPA concentration for stimulation of DNA synthesis and growth of melanocytes (10 ng/ml TPA) also supported a relatively high level of PKC enzyme activity, increased membrane association of the PKC alpha and PKC epsilon isoforms, and led to a high level of phosphorylation of a major PKC substrate, the myristoylated alanine-rich C kinase substrate (MARCKS) protein.	Tetradecanoylphorbol Acetate	55-58	myristoylated alanine rich protein kinase C substrate	Homo sapiens	357-402
1643643-4	1992	Dose-response studies revealed that the most effective TPA concentration for stimulation of DNA synthesis and growth of melanocytes (10 ng/ml TPA) also supported a relatively high level of PKC enzyme activity, increased membrane association of the PKC alpha and PKC epsilon isoforms, and led to a high level of phosphorylation of a major PKC substrate, the myristoylated alanine-rich C kinase substrate (MARCKS) protein.	Tetradecanoylphorbol Acetate	55-58	myristoylated alanine rich protein kinase C substrate	Homo sapiens	404-410
1643643-4	1992	Dose-response studies revealed that the most effective TPA concentration for stimulation of DNA synthesis and growth of melanocytes (10 ng/ml TPA) also supported a relatively high level of PKC enzyme activity, increased membrane association of the PKC alpha and PKC epsilon isoforms, and led to a high level of phosphorylation of a major PKC substrate, the myristoylated alanine-rich C kinase substrate (MARCKS) protein.	Tetradecanoylphorbol Acetate	142-145	myristoylated alanine rich protein kinase C substrate	Homo sapiens	357-402
1643643-4	1992	Dose-response studies revealed that the most effective TPA concentration for stimulation of DNA synthesis and growth of melanocytes (10 ng/ml TPA) also supported a relatively high level of PKC enzyme activity, increased membrane association of the PKC alpha and PKC epsilon isoforms, and led to a high level of phosphorylation of a major PKC substrate, the myristoylated alanine-rich C kinase substrate (MARCKS) protein.	Tetradecanoylphorbol Acetate	142-145	myristoylated alanine rich protein kinase C substrate	Homo sapiens	404-410
1643643-5	1992	Melanocytes incubated for 48 h with TPA at a higher concentration (100 ng/ml TPA) exhibited suboptimal TPA-stimulated DNA synthesis (28% of maximal) and decreased phosphorylation of the MARCKS substrate protein (50% of maximal).	Tetradecanoylphorbol Acetate	36-39	myristoylated alanine rich protein kinase C substrate	Homo sapiens	186-192
1632072-1	1992	Interleukin-2-dependent pathways of lymphocyte activation were investigated in canine peripheral blood lymphocytes (PBL) following stimulation with T-cell mitogens including phytohemagglutinin, phorbol ester (TPA), calcium ionophore (ionomycin), and human recombinant interleukin-2 (hrIL-2).	Tetradecanoylphorbol Acetate	209-212	interleukin 2	Canis lupus familiaris	0-13
1585373-11	1992	In contrast, PMA pretreatment, which depletes PKC, significantly attenuated the latter effect of EGF, suggesting that downregulation by PKC of EGF-induced increases in 45Ca and 210Pb efflux.	Tetradecanoylphorbol Acetate	13-16	epidermal growth factor like 1	Rattus norvegicus	97-100
1603084-4	1992	Treatment of cells in serum-free medium containing 0.25% BSA (MEM + BSA) with the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) decreased IGF-I and increased bFGF mRNA levels in a time- and dose-dependent fashion.	Tetradecanoylphorbol Acetate	112-143	fibroblast growth factor 2	Rattus norvegicus	180-184
1643643-5	1992	Melanocytes incubated for 48 h with TPA at a higher concentration (100 ng/ml TPA) exhibited suboptimal TPA-stimulated DNA synthesis (28% of maximal) and decreased phosphorylation of the MARCKS substrate protein (50% of maximal).	Tetradecanoylphorbol Acetate	77-80	myristoylated alanine rich protein kinase C substrate	Homo sapiens	186-192
1643643-5	1992	Melanocytes incubated for 48 h with TPA at a higher concentration (100 ng/ml TPA) exhibited suboptimal TPA-stimulated DNA synthesis (28% of maximal) and decreased phosphorylation of the MARCKS substrate protein (50% of maximal).	Tetradecanoylphorbol Acetate	77-80	myristoylated alanine rich protein kinase C substrate	Homo sapiens	186-192
1585373-11	1992	In contrast, PMA pretreatment, which depletes PKC, significantly attenuated the latter effect of EGF, suggesting that downregulation by PKC of EGF-induced increases in 45Ca and 210Pb efflux.	Tetradecanoylphorbol Acetate	13-16	epidermal growth factor like 1	Rattus norvegicus	143-146
1314584-4	1992	TPA plus A23187 resulted in phosphorylation of a 14 kDa protein, in addition to hsp27.	Tetradecanoylphorbol Acetate	0-3	heat shock protein family B (small) member 1	Rattus norvegicus	80-85
1352926-3	1992	The chemiluminescence of patient neutrophils activated by C3b-opsonized particles was, consequently, significantly decreased compared with that of control neutrophils, while the respiratory burst assayed by phorbolmyristate acid (PMA) stimulated nitroblue tetrazolium (NBT)-reduction was normal in the patient group.	Tetradecanoylphorbol Acetate	230-233	endogenous retrovirus group K member 3	Homo sapiens	58-61
1451778-3	1992	Pretreatment with phorbol 12-myristate 13-acetate (PMA) caused a down-regulation in hHGF secretion.	Tetradecanoylphorbol Acetate	18-49	hepatocyte growth factor	Homo sapiens	84-88
1451778-3	1992	Pretreatment with phorbol 12-myristate 13-acetate (PMA) caused a down-regulation in hHGF secretion.	Tetradecanoylphorbol Acetate	51-54	hepatocyte growth factor	Homo sapiens	84-88
1451778-4	1992	hHGF secreted by the PMA-treated cells showed a potent hepatocyte growth-promoting activity which was neutralized by an anti-hHGF antiserum.	Tetradecanoylphorbol Acetate	21-24	hepatocyte growth factor	Homo sapiens	0-4
1451778-4	1992	hHGF secreted by the PMA-treated cells showed a potent hepatocyte growth-promoting activity which was neutralized by an anti-hHGF antiserum.	Tetradecanoylphorbol Acetate	21-24	hepatocyte growth factor	Homo sapiens	125-129
1634770-2	1992	To illuminate mechanisms that may couple these events, we examined the expression and function of tetradecanoyl phorbol acetate-response element (TRE)-binding proteins (i.e., activator protein 1, (AP-1)) in the murine B lymphoma cell line BAL-17.7.1 (BAL-17), which models primary B lymphocyte responses in a number of respects.	Tetradecanoylphorbol Acetate	98-127	jun proto-oncogene	Mus musculus	175-194
1644168-1	1992	TPA induces down-regulation of PKC eta but not PKC zeta.	Tetradecanoylphorbol Acetate	0-3	endothelin receptor type A	Mus musculus	35-38
1373777-9	1992	In contrast, phorbol myristate acetate lowered CD14+ mean fluorescence levels.	Tetradecanoylphorbol Acetate	13-38	CD14 molecule	Homo sapiens	47-51
1644168-5	1992	Whereas epidermal PKC eta is completely down-regulated by treatment of mouse skin with TPA or bryostatin 1 for 18 h, PKC zeta is neither translocated by treatment with TPA for 20 min, nor down-regulated by treatment with TPA or bryostatin 1 for 18 h. PKC zeta is activated by phosphatidyl serine alone and does neither respond to Ca2+ nor to TPA.	Tetradecanoylphorbol Acetate	87-90	endothelin receptor type A	Mus musculus	22-25
1333455-3	1992	Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself.	Tetradecanoylphorbol Acetate	36-61	interleukin 2 receptor subunit alpha	Homo sapiens	94-98
1451778-5	1992	These results indicate both that PMA-treated human skin fibroblasts produce biologically active hHGF and the possible involvement of PKC activation in this process.	Tetradecanoylphorbol Acetate	33-36	hepatocyte growth factor	Homo sapiens	96-100
1566818-2	1992	The B lymphoblastoid line JY expresses both LFA-1 and ICAM-1, and intercellular adhesion is enhanced by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which also induced capping of LFA-1, ICAM-1, and human leukocyte antigen.	Tetradecanoylphorbol Acetate	137-168	integrin subunit alpha L	Homo sapiens	44-49
1588792-0	1992	Phorbol myristate acetate-induced expression of high-affinity interleukin 2 receptors and production of interleukin 2 by human acute lymphoblastic leukemia T cells.	Tetradecanoylphorbol Acetate	0-25	interleukin 2 receptor subunit alpha	Homo sapiens	62-85
1566818-2	1992	The B lymphoblastoid line JY expresses both LFA-1 and ICAM-1, and intercellular adhesion is enhanced by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which also induced capping of LFA-1, ICAM-1, and human leukocyte antigen.	Tetradecanoylphorbol Acetate	137-168	integrin subunit alpha L	Homo sapiens	206-211
1566818-2	1992	The B lymphoblastoid line JY expresses both LFA-1 and ICAM-1, and intercellular adhesion is enhanced by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which also induced capping of LFA-1, ICAM-1, and human leukocyte antigen.	Tetradecanoylphorbol Acetate	170-173	integrin subunit alpha L	Homo sapiens	44-49
1333455-3	1992	Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself.	Tetradecanoylphorbol Acetate	36-61	interleukin 2 receptor subunit beta	Homo sapiens	100-113
1333455-3	1992	Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself.	Tetradecanoylphorbol Acetate	36-61	interleukin 2 receptor subunit alpha	Homo sapiens	115-118
1333455-3	1992	Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself.	Tetradecanoylphorbol Acetate	63-66	interleukin 2 receptor subunit alpha	Homo sapiens	94-98
1333455-3	1992	Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself.	Tetradecanoylphorbol Acetate	63-66	interleukin 2 receptor subunit alpha	Homo sapiens	115-118
1566818-2	1992	The B lymphoblastoid line JY expresses both LFA-1 and ICAM-1, and intercellular adhesion is enhanced by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which also induced capping of LFA-1, ICAM-1, and human leukocyte antigen.	Tetradecanoylphorbol Acetate	170-173	integrin subunit alpha L	Homo sapiens	206-211
1588792-1	1992	The effect of phorbol myristate acetate (PMA) on the expression of interleukin 2 receptors (IL-2R), production of IL-2 and IL-2-dependent proliferation of acute lymphoblastic leukemia T cells (T-ALL cells) from 10 patients was studied.	Tetradecanoylphorbol Acetate	41-44	interleukin 2 receptor subunit alpha	Homo sapiens	67-90
1371947-1	1992	The preferential growth of CD3-CD2-CD11a/CD18- thymocytes was obtained by stimulation of CD2-CD3- thymic cells with low doses of PMA (0.5 ng/ml) and subsequent culture in the presence of recombinant interleukin-2 (100 U/ml).	Tetradecanoylphorbol Acetate	129-132	integrin subunit alpha L	Homo sapiens	35-40
1588792-1	1992	The effect of phorbol myristate acetate (PMA) on the expression of interleukin 2 receptors (IL-2R), production of IL-2 and IL-2-dependent proliferation of acute lymphoblastic leukemia T cells (T-ALL cells) from 10 patients was studied.	Tetradecanoylphorbol Acetate	41-44	interleukin 2 receptor subunit alpha	Homo sapiens	92-97
1588792-5	1992	We found that PMA induced the expression of both IL-2R alpha and IL-2R beta chains, as well as IL-2 production by T-ALL cells.	Tetradecanoylphorbol Acetate	14-17	interleukin 2 receptor subunit alpha	Homo sapiens	49-60
1515019-8	1992	However, short-term exposure to TPA markedly reduced glucose-induced steady-state [Ca2+]i, despite potentiating glucose-stimulated insulin release sevenfold, and blocked the [Ca2+]i increase induced by vasopressin.	Tetradecanoylphorbol Acetate	32-35	insulin	Mesocricetus auratus	131-138
1588792-5	1992	We found that PMA induced the expression of both IL-2R alpha and IL-2R beta chains, as well as IL-2 production by T-ALL cells.	Tetradecanoylphorbol Acetate	14-17	interleukin 2 receptor subunit beta	Homo sapiens	65-75
1375869-5	1992	After 50 wk of promotion with 12-O-tetradecanoylphorbol-13-acetate, the pattern of expression of K13 and K1 in SSIN mice was comparable to the pattern observed in outbred SENCAR mice after 10 to 20 wk of promotion with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	30-66	keratin 13	Mus musculus	97-100
1588792-8	1992	In two cases tested high-affinity IL-2R on PMA-treated T-ALL cells could internalize 125I-rIL-2 at 37 degrees C. PMA alone enhanced the spontaneous proliferation of T-ALL cells in three cases, whereas a clear synergy between IL-2 and PMA could be detected in three patients" cells.	Tetradecanoylphorbol Acetate	43-46	interleukin 2 receptor subunit alpha	Homo sapiens	34-39
1375869-5	1992	After 50 wk of promotion with 12-O-tetradecanoylphorbol-13-acetate, the pattern of expression of K13 and K1 in SSIN mice was comparable to the pattern observed in outbred SENCAR mice after 10 to 20 wk of promotion with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	219-255	keratin 13	Mus musculus	97-100
1371954-2	1992	Interestingly, LAM exhibited a down-regulatory effect on the accumulation of mRNAs for IL-2, IL-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-2 receptor alpha (IL-2R alpha) in T cells co-stimulated with phytohaemagglutinin-P (PHA) and 4 beta-phorbol-12-myristyl-13-acetate (PMA).	Tetradecanoylphorbol Acetate	297-300	interleukin 2 receptor subunit alpha	Homo sapiens	183-194
1348695-4	1992	Instead, staurosporine inhibited TPA-induced phosphorylation of p80.	Tetradecanoylphorbol Acetate	33-36	coilin	Homo sapiens	64-67
1545825-7	1992	Reduction of GAP expression to near normal levels restored the ability of the cells to activate p42mapk in response to TPA.	Tetradecanoylphorbol Acetate	119-122	cyclin-dependent kinase 20	Mus musculus	96-99
1371401-2	1992	Hamster cells transfected with and overexpressing mouse mdr1 or mouse mdr3 exhibit high levels of resistance to TPP+ and TPA+ (20-fold) and somewhat lower levels of resistance to TPMP+ and DDP+ (3-12-fold).	Tetradecanoylphorbol Acetate	121-124	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	70-74
1383560-0	1992	AP-1 complex and c-fos transcription are involved in TPA provoked and trans-synaptic inductions of the tyrosine hydroxylase gene: insights into long-term regulatory mechanisms.	Tetradecanoylphorbol Acetate	53-56	tyrosine hydroxylase	Rattus norvegicus	103-123
1348930-5	1992	Furthermore, we have observed that the expression of three HOX 1 genes within B lymphoid lineages is stage-related and that the expression of several of them is switched off during TPA-induced differentiation of Kg1 and U937.	Tetradecanoylphorbol Acetate	181-184	homeobox A cluster	Homo sapiens	59-64
1383560-1	1992	We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis.	Tetradecanoylphorbol Acetate	49-52	tyrosine hydroxylase	Rattus norvegicus	143-163
1383560-1	1992	We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis.	Tetradecanoylphorbol Acetate	49-52	tyrosine hydroxylase	Rattus norvegicus	165-167
1383560-8	1992	Trans-activation experiments with plasmids TRE-TH/TK/CAT and -754/-19 TH/pUC18-CAT in PC12 cells showed an increase in CAT activity in response to TPA that correlates with the previously observed increase in TH transcriptional activity by TPA.	Tetradecanoylphorbol Acetate	147-150	tyrosine hydroxylase	Rattus norvegicus	47-49
1371401-4	1992	Studies with radiolabeled TPP+ and TPA+ demonstrate that increased resistance to cytotoxic concentrations of these lipophilic cations is correlated quantitatively with a decrease in intracellular accumulation in mdr1- and mdr3-transfected cells.	Tetradecanoylphorbol Acetate	35-38	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	222-226
1312392-7	1992	Thus, NGF-induced tyrosine phosphorylation occurs both prior to and following Ras action, and Ras plays a critical role in the NGF- and TPA-induced tyrosine phosphorylation of MAPKs.	Tetradecanoylphorbol Acetate	136-139	nerve growth factor	Rattus norvegicus	6-9
1310679-4	1992	In primary cultures of dog thyrocytes, dedifferentiation of the cells by treatment with epidermal growth factor or 12-O-tetradecanoylphorbol-13-acetate led to decreased TSHr mRNA levels and nearly abolished thyroglobulin and TPO gene expression.	Tetradecanoylphorbol Acetate	115-151	thyroid peroxidase	Canis lupus familiaris	225-228
1383560-8	1992	Trans-activation experiments with plasmids TRE-TH/TK/CAT and -754/-19 TH/pUC18-CAT in PC12 cells showed an increase in CAT activity in response to TPA that correlates with the previously observed increase in TH transcriptional activity by TPA.	Tetradecanoylphorbol Acetate	147-150	tyrosine hydroxylase	Rattus norvegicus	70-72
1383560-8	1992	Trans-activation experiments with plasmids TRE-TH/TK/CAT and -754/-19 TH/pUC18-CAT in PC12 cells showed an increase in CAT activity in response to TPA that correlates with the previously observed increase in TH transcriptional activity by TPA.	Tetradecanoylphorbol Acetate	147-150	tyrosine hydroxylase	Rattus norvegicus	70-72
1383560-8	1992	Trans-activation experiments with plasmids TRE-TH/TK/CAT and -754/-19 TH/pUC18-CAT in PC12 cells showed an increase in CAT activity in response to TPA that correlates with the previously observed increase in TH transcriptional activity by TPA.	Tetradecanoylphorbol Acetate	239-242	tyrosine hydroxylase	Rattus norvegicus	47-49
1383560-8	1992	Trans-activation experiments with plasmids TRE-TH/TK/CAT and -754/-19 TH/pUC18-CAT in PC12 cells showed an increase in CAT activity in response to TPA that correlates with the previously observed increase in TH transcriptional activity by TPA.	Tetradecanoylphorbol Acetate	239-242	tyrosine hydroxylase	Rattus norvegicus	70-72
1383560-8	1992	Trans-activation experiments with plasmids TRE-TH/TK/CAT and -754/-19 TH/pUC18-CAT in PC12 cells showed an increase in CAT activity in response to TPA that correlates with the previously observed increase in TH transcriptional activity by TPA.	Tetradecanoylphorbol Acetate	239-242	tyrosine hydroxylase	Rattus norvegicus	70-72
1504019-3	1992	Following 12-O-tetradecanoylphorbol-13-acetate treatment of adult mouse skin, there was a rapid induction of TGF-beta 1 protein.	Tetradecanoylphorbol Acetate	10-46	transforming growth factor, beta 1	Mus musculus	109-119
1504019-5	1992	Despite ubiquitous induction of TGF-beta 1 protein by 12-O-tetradecanoylphorbol-13-acetate in various mouse strains, we noted strain-specific differences in the quantitative induction of TGF-beta 1 RNA.	Tetradecanoylphorbol Acetate	54-90	transforming growth factor, beta 1	Mus musculus	32-42
1540391-2	1992	The elastase inhibitors, elastatinal, alpha 1-antitrypsin, and MeO-Suc-(Ala)2-Pro-Val-CH2Cl, significantly inhibited xanthine dehydrogenase to oxidase conversion by phorbol myristate acetate-stimulated neutrophils without inhibition of neutrophil adherence to the endothelial cell monolayer.	Tetradecanoylphorbol Acetate	165-190	xanthine dehydrogenase	Homo sapiens	117-139
1735341-7	1992	Moreover, the tumor promoter, tetradecanoylphorbol acetate (TPA), down-regulates the EGF receptor.	Tetradecanoylphorbol Acetate	30-58	epidermal growth factor like 1	Rattus norvegicus	85-88
1311244-6	1992	At variance with TSH, cell incubation with either 8-bromo-cAMP or the protein kinase-C activator 12-O-tetradecanoylphorbol-13-acetate inhibited insulin and IGF-I receptor kinases.	Tetradecanoylphorbol Acetate	97-133	insulin-like growth factor 1 receptor	Rattus norvegicus	156-170
1735341-7	1992	Moreover, the tumor promoter, tetradecanoylphorbol acetate (TPA), down-regulates the EGF receptor.	Tetradecanoylphorbol Acetate	60-63	epidermal growth factor like 1	Rattus norvegicus	85-88
1309506-9	1992	Phosphorylation of connexin43 increased during the first 2 h of TPA treatment.	Tetradecanoylphorbol Acetate	64-67	gap junction protein alpha 1	Bos taurus	19-29
1354270-4	1992	Phorbolmyristate acetate (PMA) stimulated APN but not APA expression after a lag time of 12 hours.	Tetradecanoylphorbol Acetate	0-24	alanyl aminopeptidase, membrane	Homo sapiens	42-45
1354270-4	1992	Phorbolmyristate acetate (PMA) stimulated APN but not APA expression after a lag time of 12 hours.	Tetradecanoylphorbol Acetate	26-29	alanyl aminopeptidase, membrane	Homo sapiens	42-45
1374055-6	1992	In addition, PMN primed in vivo with rh G-CSF released more superoxide anions when stimulated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	99-124	colony stimulating factor 3 (granulocyte)	Mus musculus	40-45
1594601-5	1992	Cotransfection experiments showed that the increase in c-jun expression resulted from elevated activity of the transcription factor AP-1 and was mediated through the phorbol 12-tetradecanoate 13-acetate response element in the c-jun promoter.	Tetradecanoylphorbol Acetate	166-202	jun proto-oncogene	Mus musculus	55-60
1370514-8	1992	Stimulation with Con A also induced very low or no measurable levels of IL-2 and IFN-gamma, whereas activation with TPA and the calcium ionophore A23187 resulted in the production of high levels of IL-4, IL-5, IL-2, and IFN-gamma.	Tetradecanoylphorbol Acetate	116-119	interleukin 5	Homo sapiens	204-208
1310050-0	1992	Synergistic effects of 12-O-tetradecanoylphorbol-13-acetate and dexamethasone on de novo synthesis of histidine decarboxylase in mouse mastocytoma P-815 cells.	Tetradecanoylphorbol Acetate	23-59	histidine decarboxylase	Mus musculus	102-125
1594601-5	1992	Cotransfection experiments showed that the increase in c-jun expression resulted from elevated activity of the transcription factor AP-1 and was mediated through the phorbol 12-tetradecanoate 13-acetate response element in the c-jun promoter.	Tetradecanoylphorbol Acetate	166-202	jun proto-oncogene	Mus musculus	132-136
1322299-6	1992	However, 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibited dye coupling and induced an increase in the amount of phosphorylated forms of Cx43 at the expense of the dephosphorylated form.	Tetradecanoylphorbol Acetate	9-45	gap junction protein alpha 1	Canis lupus familiaris	140-144
1594601-5	1992	Cotransfection experiments showed that the increase in c-jun expression resulted from elevated activity of the transcription factor AP-1 and was mediated through the phorbol 12-tetradecanoate 13-acetate response element in the c-jun promoter.	Tetradecanoylphorbol Acetate	166-202	jun proto-oncogene	Mus musculus	227-232
1317102-4	1992	TPA decreased the high K(+)-stimulated increase in intracellular free calcium ion concentration ([Ca2+]i) from 8.5- to 3.2-fold by 5 min and to 2.0-fold after 18 h without altering the peak [Ca2+]i response to the peptide hormone TRH.	Tetradecanoylphorbol Acetate	0-3	thyrotropin releasing hormone	Rattus norvegicus	230-233
1310051-13	1992	Furthermore, the mechanism underlying the induction of HDC by db cAMP plus A23187 is distinguishable from that in the case of dexamethasone plus TPA, since preexposure to dexamethasone plus TPA for 12 h, for a plateau level to be reached, did not affect the subsequent increase in HDC activity due to db cAMP plus A23187.	Tetradecanoylphorbol Acetate	190-193	histidine decarboxylase	Mus musculus	55-58
1310051-13	1992	Furthermore, the mechanism underlying the induction of HDC by db cAMP plus A23187 is distinguishable from that in the case of dexamethasone plus TPA, since preexposure to dexamethasone plus TPA for 12 h, for a plateau level to be reached, did not affect the subsequent increase in HDC activity due to db cAMP plus A23187.	Tetradecanoylphorbol Acetate	190-193	histidine decarboxylase	Mus musculus	281-284
1322299-6	1992	However, 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibited dye coupling and induced an increase in the amount of phosphorylated forms of Cx43 at the expense of the dephosphorylated form.	Tetradecanoylphorbol Acetate	47-50	gap junction protein alpha 1	Canis lupus familiaris	140-144
1731339-2	1992	We now find that this EpRE is composed of two adjacent 9-base-pair motifs related in sequence to the AP-1 binding site, a transcriptional enhancer originally identified as the phorbol 12-myristate 13-acetate (PMA) response element and known to be regulated by the binding of protein products of c-jun and c-fos genes.	Tetradecanoylphorbol Acetate	176-207	jun proto-oncogene	Mus musculus	295-300
1572907-7	1992	TGF-alpha and the PKC activator tetradecanoyl phorbol 12-myristyl, 13-acetate (TPA) had similar effects on TGF-alpha steady-state mRNA levels, suggesting that PKC activation might be a downstream mediator of TGF-alpha autoinduction.	Tetradecanoylphorbol Acetate	79-82	transforming growth factor alpha	Homo sapiens	107-116
1312489-2	1992	24 h treatment of MDBK cells with TPA resulted in down-regulation of VDR number, with no change in the binding affinity for 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) or approximate molecular weight determined by fast protein liquid chromatography (FPLC).	Tetradecanoylphorbol Acetate	34-37	vitamin D receptor	Bos taurus	69-72
1572907-7	1992	TGF-alpha and the PKC activator tetradecanoyl phorbol 12-myristyl, 13-acetate (TPA) had similar effects on TGF-alpha steady-state mRNA levels, suggesting that PKC activation might be a downstream mediator of TGF-alpha autoinduction.	Tetradecanoylphorbol Acetate	79-82	transforming growth factor alpha	Homo sapiens	107-116
1572907-8	1992	However, down-regulation of more than 90% of keratinocyte PKC activity by bryostatin pretreatment abrogated the induction of TGF-alpha mRNA in response to TPA without affecting the autoinductive response or EGF-stimulated tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	155-158	transforming growth factor alpha	Homo sapiens	125-134
1731339-2	1992	We now find that this EpRE is composed of two adjacent 9-base-pair motifs related in sequence to the AP-1 binding site, a transcriptional enhancer originally identified as the phorbol 12-myristate 13-acetate (PMA) response element and known to be regulated by the binding of protein products of c-jun and c-fos genes.	Tetradecanoylphorbol Acetate	209-212	jun proto-oncogene	Mus musculus	295-300
1309491-2	1992	STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	186-217	interleukin 2 receptor subunit beta	Homo sapiens	72-85
1309491-2	1992	STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	186-217	interleukin 2 receptor subunit alpha	Homo sapiens	87-92
1309491-2	1992	STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	186-217	interleukin 2 receptor subunit alpha	Homo sapiens	93-96
1309491-2	1992	STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	219-222	interleukin 2 receptor subunit beta	Homo sapiens	72-85
1635909-3	1992	A tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) also stimulated hCG release while two non-tumor-promoting compounds, phorbol and 4 alpha-phorbol, failed to stimulate hCG release.	Tetradecanoylphorbol Acetate	33-69	chorionic gonadotropin subunit beta 5	Homo sapiens	92-95
1635909-3	1992	A tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) also stimulated hCG release while two non-tumor-promoting compounds, phorbol and 4 alpha-phorbol, failed to stimulate hCG release.	Tetradecanoylphorbol Acetate	71-74	chorionic gonadotropin subunit beta 5	Homo sapiens	92-95
1309491-2	1992	STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	219-222	interleukin 2 receptor subunit alpha	Homo sapiens	87-92
1312489-5	1992	TPA elicited a significant decrease in membrane-associated protein kinase C (PKC) activity which coincided with the reduction in VDR number and calbindin D-28K.	Tetradecanoylphorbol Acetate	0-3	vitamin D receptor	Bos taurus	129-132
1309491-2	1992	STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	219-222	interleukin 2 receptor subunit alpha	Homo sapiens	93-96
1370479-14	1992	Treatment of human KB epidermoid carcinoma cells with phorbol 12-myristate 13-acetate (PMA) lead to a rapid induction of GCF RNA after 1 h and a decline to lower than control levels after 6 h. Epidermal growth factor receptor mRNAs were not increased by PMA until 2 h after treatment and were at their highest level only after GCF mRNAs were decreased.	Tetradecanoylphorbol Acetate	54-85	GC-rich sequence DNA-binding factor 2	Homo sapiens	121-124
1635909-3	1992	A tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) also stimulated hCG release while two non-tumor-promoting compounds, phorbol and 4 alpha-phorbol, failed to stimulate hCG release.	Tetradecanoylphorbol Acetate	71-74	chorionic gonadotropin subunit beta 5	Homo sapiens	194-197
1370479-14	1992	Treatment of human KB epidermoid carcinoma cells with phorbol 12-myristate 13-acetate (PMA) lead to a rapid induction of GCF RNA after 1 h and a decline to lower than control levels after 6 h. Epidermal growth factor receptor mRNAs were not increased by PMA until 2 h after treatment and were at their highest level only after GCF mRNAs were decreased.	Tetradecanoylphorbol Acetate	54-85	GC-rich sequence DNA-binding factor 2	Homo sapiens	327-330
1617156-8	1992	As expected, activation of cells with phorbol myristate acetate (PMA) resulted in a notable increase in the level of CD69 on all cell lines considered except for the epithelial and fibroblastic types.	Tetradecanoylphorbol Acetate	38-63	CD69 molecule	Homo sapiens	117-121
1370479-14	1992	Treatment of human KB epidermoid carcinoma cells with phorbol 12-myristate 13-acetate (PMA) lead to a rapid induction of GCF RNA after 1 h and a decline to lower than control levels after 6 h. Epidermal growth factor receptor mRNAs were not increased by PMA until 2 h after treatment and were at their highest level only after GCF mRNAs were decreased.	Tetradecanoylphorbol Acetate	87-90	GC-rich sequence DNA-binding factor 2	Homo sapiens	121-124
1617156-8	1992	As expected, activation of cells with phorbol myristate acetate (PMA) resulted in a notable increase in the level of CD69 on all cell lines considered except for the epithelial and fibroblastic types.	Tetradecanoylphorbol Acetate	65-68	CD69 molecule	Homo sapiens	117-121
1370479-14	1992	Treatment of human KB epidermoid carcinoma cells with phorbol 12-myristate 13-acetate (PMA) lead to a rapid induction of GCF RNA after 1 h and a decline to lower than control levels after 6 h. Epidermal growth factor receptor mRNAs were not increased by PMA until 2 h after treatment and were at their highest level only after GCF mRNAs were decreased.	Tetradecanoylphorbol Acetate	87-90	GC-rich sequence DNA-binding factor 2	Homo sapiens	327-330
1591268-3	1992	The set point of control platelets (7.28 +/- 0.01) is shifted rapidly (discernibly less than or equal to 30 s) and markedly to alkaline pHi (7.62 +/- 0.03) by PMA, that activates protein kinase C and is shifted to acidic pHi (7.05 +/- 0.01) by staurosporine, which inhibits protein kinases.	Tetradecanoylphorbol Acetate	159-162	glucose-6-phosphate isomerase	Homo sapiens	136-139
1591268-3	1992	The set point of control platelets (7.28 +/- 0.01) is shifted rapidly (discernibly less than or equal to 30 s) and markedly to alkaline pHi (7.62 +/- 0.03) by PMA, that activates protein kinase C and is shifted to acidic pHi (7.05 +/- 0.01) by staurosporine, which inhibits protein kinases.	Tetradecanoylphorbol Acetate	159-162	glucose-6-phosphate isomerase	Homo sapiens	221-224
1310050-1	1992	12-O-Tetradecanoylphorbol-13-acetate (TPA) markedly enhanced the increase in L-histidine decarboxylase (HDC) activity induced by dexamethasone in mouse mastocytoma P-815 cells, even with a concentration of the latter that had the maximal effect, whereas it induced a rapid and transient increase in HDC activity, which peaked after 3 h in the absence of dexamethasone.	Tetradecanoylphorbol Acetate	0-36	histidine decarboxylase	Mus musculus	77-102
1333409-3	1992	Phosphoprotein phosphatase 2A dephosphorylated eIF-4E isolated from both phorbol 12-myristate 13-acetate- or okadaic acid-treated cells, whereas alkaline and acid phosphatase were relatively ineffective.	Tetradecanoylphorbol Acetate	73-104	eukaryotic translation initiation factor 4E	Homo sapiens	47-53
1307243-4	1992	Co-stimulation with PHA + phorbol myristate acetate in the absence of AC restored both proliferation and CD25 expression in the aged.	Tetradecanoylphorbol Acetate	26-51	interleukin 2 receptor subunit alpha	Homo sapiens	105-109
1310050-1	1992	12-O-Tetradecanoylphorbol-13-acetate (TPA) markedly enhanced the increase in L-histidine decarboxylase (HDC) activity induced by dexamethasone in mouse mastocytoma P-815 cells, even with a concentration of the latter that had the maximal effect, whereas it induced a rapid and transient increase in HDC activity, which peaked after 3 h in the absence of dexamethasone.	Tetradecanoylphorbol Acetate	0-36	histidine decarboxylase	Mus musculus	104-107
1371989-9	1992	The expression of both the 85-kDa protein and CD-14 was drastically reduced during the megakaryocytic differentiation of the HEL cells with TPA.	Tetradecanoylphorbol Acetate	140-143	CD14 molecule	Homo sapiens	46-51
1310050-1	1992	12-O-Tetradecanoylphorbol-13-acetate (TPA) markedly enhanced the increase in L-histidine decarboxylase (HDC) activity induced by dexamethasone in mouse mastocytoma P-815 cells, even with a concentration of the latter that had the maximal effect, whereas it induced a rapid and transient increase in HDC activity, which peaked after 3 h in the absence of dexamethasone.	Tetradecanoylphorbol Acetate	0-36	histidine decarboxylase	Mus musculus	299-302
1543537-3	1992	The nuclear proto-oncogenes c-fos and c-jun are referred to as early response genes because the classical tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces their expression to maximal levels within 2 h after treatment.	Tetradecanoylphorbol Acetate	121-157	jun proto-oncogene	Mus musculus	38-43
1313769-0	1992	Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.	Tetradecanoylphorbol Acetate	8-11	jun proto-oncogene	Mus musculus	46-50
1310050-1	1992	12-O-Tetradecanoylphorbol-13-acetate (TPA) markedly enhanced the increase in L-histidine decarboxylase (HDC) activity induced by dexamethasone in mouse mastocytoma P-815 cells, even with a concentration of the latter that had the maximal effect, whereas it induced a rapid and transient increase in HDC activity, which peaked after 3 h in the absence of dexamethasone.	Tetradecanoylphorbol Acetate	38-41	histidine decarboxylase	Mus musculus	77-102
1543537-3	1992	The nuclear proto-oncogenes c-fos and c-jun are referred to as early response genes because the classical tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces their expression to maximal levels within 2 h after treatment.	Tetradecanoylphorbol Acetate	159-162	jun proto-oncogene	Mus musculus	38-43
1310050-1	1992	12-O-Tetradecanoylphorbol-13-acetate (TPA) markedly enhanced the increase in L-histidine decarboxylase (HDC) activity induced by dexamethasone in mouse mastocytoma P-815 cells, even with a concentration of the latter that had the maximal effect, whereas it induced a rapid and transient increase in HDC activity, which peaked after 3 h in the absence of dexamethasone.	Tetradecanoylphorbol Acetate	38-41	histidine decarboxylase	Mus musculus	104-107
1310050-1	1992	12-O-Tetradecanoylphorbol-13-acetate (TPA) markedly enhanced the increase in L-histidine decarboxylase (HDC) activity induced by dexamethasone in mouse mastocytoma P-815 cells, even with a concentration of the latter that had the maximal effect, whereas it induced a rapid and transient increase in HDC activity, which peaked after 3 h in the absence of dexamethasone.	Tetradecanoylphorbol Acetate	38-41	histidine decarboxylase	Mus musculus	299-302
1310050-2	1992	The synergistic effect of TPA on HDC activity induced by dexamethasone was detected after 4 h, a plateau level being reached by 6 h, which was similar to the time course with dexamethasone alone.	Tetradecanoylphorbol Acetate	26-29	histidine decarboxylase	Mus musculus	33-36
1742484-9	1991	Aphidicolin, a specific inhibitor of DNA polymerase alpha, completely inhibited the differentiation induction of MEG-O1 cells with TPA measured by either GP IIb/IIIa expression or multinuclear cell formation.	Tetradecanoylphorbol Acetate	131-134	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	37-57
1310050-3	1992	TPA enhanced the induction of HDC activity by various glucocorticoids, but had no effect on the induction by dibutyryl cAMP, prostaglandin E2 or sodium butyrate.	Tetradecanoylphorbol Acetate	0-3	histidine decarboxylase	Mus musculus	30-33
1742484-9	1991	Aphidicolin, a specific inhibitor of DNA polymerase alpha, completely inhibited the differentiation induction of MEG-O1 cells with TPA measured by either GP IIb/IIIa expression or multinuclear cell formation.	Tetradecanoylphorbol Acetate	131-134	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	113-116
1742485-3	1991	Upon differentiation induced by phorbol ester (phorbol 12-myristate 13-acetate [PMA]), metabolites via the COX pathway were increased by 100-fold in ML-1 and THP-1 cells, while the LOX products remained barely detectable.	Tetradecanoylphorbol Acetate	47-78	interleukin 17F	Homo sapiens	149-153
1310050-4	1992	Both 1-oleoyl-2-acetylglycerol, a protein kinase C activator, and okadaic acid, a protein phosphatase inhibitor, enhanced the increase in HDC activity induced by dexamethasone, but 4 alpha-phorbol-12,13-didecanoate, an inactive derivative of TPA, did not.	Tetradecanoylphorbol Acetate	242-245	histidine decarboxylase	Mus musculus	138-141
1742485-3	1991	Upon differentiation induced by phorbol ester (phorbol 12-myristate 13-acetate [PMA]), metabolites via the COX pathway were increased by 100-fold in ML-1 and THP-1 cells, while the LOX products remained barely detectable.	Tetradecanoylphorbol Acetate	80-83	interleukin 17F	Homo sapiens	149-153
1560050-1	1992	EL 4-6.1 cells, variants of the murine EL4 thymoma cell line, can be activated by interleukin 1 (IL-1) or phorbol 12-myristate-13-acetate (PMA), or PMA+IL-1 to secrete interleukin 2 (IL-2) and interleukin 4 (IL-4) and to express the IL-2 receptor (IL-2R).	Tetradecanoylphorbol Acetate	139-142	interleukin 1 complex	Mus musculus	152-156
1310050-5	1992	Protein kinase C inhibitors, such as staurosporin, H-7 and K255a, suppressed the increase in HDC activity induced by TPA with or without dexamethasone.	Tetradecanoylphorbol Acetate	117-120	histidine decarboxylase	Mus musculus	93-96
1310050-7	1992	Furthermore, TPA markedly enhanced the accumulation of HDC mRNA due to dexamethasone (5 to 10-fold, from 6 to 12 h after).	Tetradecanoylphorbol Acetate	13-16	histidine decarboxylase	Mus musculus	55-58
1533011-5	1992	TcR-alpha mRNA levels can be dramatically augmented in RS4.2 cells by three distinct mechanisms: in response to treatment with either phorbol myristate acetate (PMA), calcium ionophore (A23187), or cycloheximide (CHX).	Tetradecanoylphorbol Acetate	134-159	T cell receptor alpha constant	Homo sapiens	0-9
1533011-5	1992	TcR-alpha mRNA levels can be dramatically augmented in RS4.2 cells by three distinct mechanisms: in response to treatment with either phorbol myristate acetate (PMA), calcium ionophore (A23187), or cycloheximide (CHX).	Tetradecanoylphorbol Acetate	161-164	T cell receptor alpha constant	Homo sapiens	0-9
1660881-11	1991	However, the 5-HT-induced stimulatory pathway in fibroblasts was blocked selectively by acute (2-min) pretreatment with TPA, an activator of protein kinase C. This action of protein kinase C was potentiated by activation of protein kinase A, indicating that the expression of the stimulatory pathway of the 5-HT1A receptor in LZD-7 cells is modulated by second messengers.	Tetradecanoylphorbol Acetate	120-123	5-hydroxytryptamine receptor 1A	Rattus norvegicus	307-313
1744113-1	1991	The effects of phorbol ester (TPA) and other known stimulators such as tumor necrosis factor (TNF), interleukin-1, and lipopolysaccharide on induction of mRNA for manganese-superoxide dismutase (Mn-SOD) were investigated in various cell lines.	Tetradecanoylphorbol Acetate	30-33	superoxide dismutase 2	Homo sapiens	163-193
1310051-4	1992	Acta 1133, 172-178), we reported that in mastocytoma P-815 cells dexamethasone and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically enhanced the de novo synthesis of L-histidine decarboxylase (HDC).	Tetradecanoylphorbol Acetate	83-119	histidine decarboxylase	Mus musculus	176-201
1744113-2	1991	TPA enhanced Mn-SOD mRNA expression in TNF-resistant cell lines including HeLa cells, in which the other reagents also induced expression of the gene, but did not affect TNF-sensitive cells, in which the other stimulators did not alter expression of the gene.	Tetradecanoylphorbol Acetate	0-3	superoxide dismutase 2	Homo sapiens	13-19
1310051-4	1992	Acta 1133, 172-178), we reported that in mastocytoma P-815 cells dexamethasone and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically enhanced the de novo synthesis of L-histidine decarboxylase (HDC).	Tetradecanoylphorbol Acetate	83-119	histidine decarboxylase	Mus musculus	203-206
1744113-3	1991	HeLa cells which had been desensitized to TPA by pretreatment with TPA for 24 h expressed Mn-SOD mRNA at a slightly higher level than the cells without TPA treatment.	Tetradecanoylphorbol Acetate	42-45	superoxide dismutase 2	Homo sapiens	90-96
1744113-3	1991	HeLa cells which had been desensitized to TPA by pretreatment with TPA for 24 h expressed Mn-SOD mRNA at a slightly higher level than the cells without TPA treatment.	Tetradecanoylphorbol Acetate	67-70	superoxide dismutase 2	Homo sapiens	90-96
1306105-2	1992	We investigated the basal levels of ODC activity in sigmoid and rectal mucosae, and basal and tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced levels of skin ODC activity in individuals with a personal history of colon cancer (n = 9 colon; n = 58 skin), a family history of nonpolyposis hereditary colorectal cancer (n = 49; n = 42), adenomas (n = 16; n = 40), and healthy, family history-negative control subjects (n = 40; n = 79).	Tetradecanoylphorbol Acetate	109-145	ornithine decarboxylase 1	Homo sapiens	169-172
1544233-2	1992	Most BMT recipient T cells detectably expressed the CD69 surface antigen after 24 h of stimulation with either phorbol 12-myristate 13-acetate (PMA) or anti-CD3 MoAb and PMA, thus indicating that PKC activity is sufficient to induce de novo gene expression.	Tetradecanoylphorbol Acetate	111-142	CD69 molecule	Homo sapiens	52-56
1744113-3	1991	HeLa cells which had been desensitized to TPA by pretreatment with TPA for 24 h expressed Mn-SOD mRNA at a slightly higher level than the cells without TPA treatment.	Tetradecanoylphorbol Acetate	67-70	superoxide dismutase 2	Homo sapiens	90-96
1744113-4	1991	TPA-pretreated cells stimulated with TNF, however, expressed Mn-SOD mRNA at about twice the level of TNF-stimulated, TPA-untreated cells.	Tetradecanoylphorbol Acetate	0-3	superoxide dismutase 2	Homo sapiens	61-67
1310051-4	1992	Acta 1133, 172-178), we reported that in mastocytoma P-815 cells dexamethasone and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically enhanced the de novo synthesis of L-histidine decarboxylase (HDC).	Tetradecanoylphorbol Acetate	121-124	histidine decarboxylase	Mus musculus	176-201
1310051-4	1992	Acta 1133, 172-178), we reported that in mastocytoma P-815 cells dexamethasone and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically enhanced the de novo synthesis of L-histidine decarboxylase (HDC).	Tetradecanoylphorbol Acetate	121-124	histidine decarboxylase	Mus musculus	203-206
1726926-4	1991	bFGF enhanced the secretion of IGFBP-2 and, like epidermal growth factor (EGF) and the tumour promoting phorbol ester (TPA), induced the appearance of IGFBP-3.	Tetradecanoylphorbol Acetate	119-122	fibroblast growth factor 2	Ovis aries	0-4
1310051-5	1992	Here we found that Ca2+ acted synergistically with cAMP in the induction of HDC mRNA and HDC activity in mastocytoma P-815 cells, and that the mechanism underlying the enzyme induction by Ca2+ plus cAMP was distinguishable from that by dexamethasone plus TPA.	Tetradecanoylphorbol Acetate	255-258	histidine decarboxylase	Mus musculus	76-79
1544233-2	1992	Most BMT recipient T cells detectably expressed the CD69 surface antigen after 24 h of stimulation with either phorbol 12-myristate 13-acetate (PMA) or anti-CD3 MoAb and PMA, thus indicating that PKC activity is sufficient to induce de novo gene expression.	Tetradecanoylphorbol Acetate	144-147	CD69 molecule	Homo sapiens	52-56
1345807-5	1992	However, treatment of leukocytes with phorbol 12-myristate 13 acetate increased CR3 and CR4 expression on both myeloid cells and a lymphocyte subpopulation.	Tetradecanoylphorbol Acetate	38-69	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	80-83
1545805-7	1992	We also show that although the mitogen and tumor promoter, phorbol 12-myristate-13-acetate, is able to induce phosphorylation of eIF-4E in PC12 cells, the NGF-mediated increase is primarily a protein kinase C-independent response.	Tetradecanoylphorbol Acetate	59-90	eukaryotic translation initiation factor 4E	Rattus norvegicus	129-135
1545805-7	1992	We also show that although the mitogen and tumor promoter, phorbol 12-myristate-13-acetate, is able to induce phosphorylation of eIF-4E in PC12 cells, the NGF-mediated increase is primarily a protein kinase C-independent response.	Tetradecanoylphorbol Acetate	59-90	nerve growth factor	Rattus norvegicus	155-158
1657961-1	1991	Phorbol 12-myristate 13-acetate activates 1-alkyl-2-lyso-sn-glycero-3-phosphate:acetyl-CoA acetyltransferase and dithiothreitol-insensitive 1-alkyl-2-acetyl-sn-glycerol:CDP-choline cholinephosphotransferase.	Tetradecanoylphorbol Acetate	0-31	cut like homeobox 1	Homo sapiens	169-172
1657961-4	1991	In the present study we show that protein kinase C activation by phorbol 12-myristate 13-acetate (PMA) induces PAF production in HUVEC by an increase of both alkyllyso-GP:acetyl-CoA acetyltransferase and DTT-insensitive alkylacetyl-G:CDP-choline choline-phosphotransferase.	Tetradecanoylphorbol Acetate	65-96	cut like homeobox 1	Homo sapiens	234-237
1657961-4	1991	In the present study we show that protein kinase C activation by phorbol 12-myristate 13-acetate (PMA) induces PAF production in HUVEC by an increase of both alkyllyso-GP:acetyl-CoA acetyltransferase and DTT-insensitive alkylacetyl-G:CDP-choline choline-phosphotransferase.	Tetradecanoylphorbol Acetate	98-101	cut like homeobox 1	Homo sapiens	234-237
1345807-5	1992	However, treatment of leukocytes with phorbol 12-myristate 13 acetate increased CR3 and CR4 expression on both myeloid cells and a lymphocyte subpopulation.	Tetradecanoylphorbol Acetate	38-69	teratocarcinoma-derived growth factor 1 pseudogene 4	Homo sapiens	88-91
1657981-2	1991	TPA increased total phosphorylation of the wild-type insulin receptor and inhibited insulin-stimulated autophosphorylation by 32 +/- 10% in HIRc cells.	Tetradecanoylphorbol Acetate	0-3	insulin receptor	Homo sapiens	53-69
1371276-2	1992	Previous experiments have shown that heparin inhibits induction of c-fos and c-myc protooncogene mRNA in rat VSMC stimulated by phorbol 12-myristate 13-acetate (PMA) but not when stimulated by epidermal growth factor (EGF) (Pukac, L. A., Castellot, J. J., Wright, T. C., Caleb, B. L., and Karnovsky, M. J.	Tetradecanoylphorbol Acetate	128-159	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	77-82
1379817-4	1992	Exposure of quiescent Mel-ab cells to the PKC-activating phorbol esters TPA or sapintoxin A at 81 nM for 2 h increased levels of mRNA for six of seven TIS genes examined (twofold to 80-fold increase in steady-state RNA levels for TIS 1, 7, 8, 11, 21, and 28 (c-fos); TIS 10 expression was not affected).	Tetradecanoylphorbol Acetate	72-75	prostaglandin-endoperoxide synthase 2	Mus musculus	267-273
1347251-3	1992	Prolonged treatment of P388/ADR cells with phorbol myristate acetate (PMA), a procedure that is known to down regulate PKC, resulted in the down regulation of total PKC activity and the PKC beta isoform (at the protein level) that was accompanied by the correction of daunorubicin accumulation in P388/ADR cells.	Tetradecanoylphorbol Acetate	43-68	protein kinase C, beta	Mus musculus	186-194
1347251-3	1992	Prolonged treatment of P388/ADR cells with phorbol myristate acetate (PMA), a procedure that is known to down regulate PKC, resulted in the down regulation of total PKC activity and the PKC beta isoform (at the protein level) that was accompanied by the correction of daunorubicin accumulation in P388/ADR cells.	Tetradecanoylphorbol Acetate	70-73	protein kinase C, beta	Mus musculus	186-194
1657981-6	1991	In conclusion, 1) TPA-induced inhibition of insulin receptor tyrosine autophosphorylation was linked to concomitant inhibition of the biological effects of insulin in cells expressing either wild-type or COOH-terminal truncated insulin receptors; and 2) the inhibitory effects of TPA were not dependent upon phosphorylation of COOH-terminal residues and furthermore appeared to be independent of phosphorylation of any insulin receptor serine/threonine residues.	Tetradecanoylphorbol Acetate	18-21	insulin receptor	Homo sapiens	44-60
1657981-6	1991	In conclusion, 1) TPA-induced inhibition of insulin receptor tyrosine autophosphorylation was linked to concomitant inhibition of the biological effects of insulin in cells expressing either wild-type or COOH-terminal truncated insulin receptors; and 2) the inhibitory effects of TPA were not dependent upon phosphorylation of COOH-terminal residues and furthermore appeared to be independent of phosphorylation of any insulin receptor serine/threonine residues.	Tetradecanoylphorbol Acetate	18-21	insulin receptor	Homo sapiens	228-244
1285482-1	1992	Mononuclear cells in peripheral blood secrete immunoreactive hCG (ir-hCG) when they are stimulated in in-vitro culture with the proteinkinase C - activator phorbol-myristat-acetate (TPA).	Tetradecanoylphorbol Acetate	182-185	chorionic gonadotropin subunit beta 5	Homo sapiens	61-64
1939109-0	1991	The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, induces specific transcription by RNA polymerase III in Drosophila Schneider cells.	Tetradecanoylphorbol Acetate	19-55	RNA polymerase III 128kD subunit	Drosophila melanogaster	91-109
1939109-1	1991	We have examined the ability of the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), to regulate RNA polymerase III gene expression in Drosophila.	Tetradecanoylphorbol Acetate	67-103	RNA polymerase III 128kD subunit	Drosophila melanogaster	123-141
1939109-1	1991	We have examined the ability of the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), to regulate RNA polymerase III gene expression in Drosophila.	Tetradecanoylphorbol Acetate	105-108	RNA polymerase III 128kD subunit	Drosophila melanogaster	123-141
1551438-1	1992	The non-mitogenic stimulation of human peripheral blood mononuclear cells (PBMC) with low concentrations of the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) caused a progressive increase in the percent fraction of the cells that were positive for the early activating antigen CD69.	Tetradecanoylphorbol Acetate	126-162	CD69 molecule	Homo sapiens	288-292
1551438-1	1992	The non-mitogenic stimulation of human peripheral blood mononuclear cells (PBMC) with low concentrations of the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) caused a progressive increase in the percent fraction of the cells that were positive for the early activating antigen CD69.	Tetradecanoylphorbol Acetate	164-167	CD69 molecule	Homo sapiens	288-292
1551438-3	1992	A further increase in TPA concentration, while inducing the maximal expression of the levels of CD69 activating surface antigen, both in the presence or in the absence of proliferative activity, did not evoke any additional hightening of pADPRP mRNA levels.	Tetradecanoylphorbol Acetate	22-25	CD69 molecule	Homo sapiens	96-100
1322299-9	1992	Treatments with staurosporine, a protein kinase inhibitor, or okadaic acid, a protein phosphatase inhibitor, either alone or in combination with TPA, indicated that the abundance of the dephosphorylated form of Cx43 in MDCK cells was due to low kinase activity.	Tetradecanoylphorbol Acetate	145-148	gap junction protein alpha 1	Canis lupus familiaris	211-215
1322299-11	1992	These results suggest that neither extracellular Ca2+ nor cell contact is required for basal or TPA-induced phosphorylation of Cx43.	Tetradecanoylphorbol Acetate	96-99	gap junction protein alpha 1	Canis lupus familiaris	127-131
1659231-8	1991	The pHi increase was abolished by 1) blockade of the Na(+)-H+ exchanger by ethyl isopropyl amiloride and 2) inhibition of protein kinase C (PKC) activity via pretreatment with staurosporine or prolonged incubation with 4 beta-phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	221-257	glucose-6-phosphate isomerase	Homo sapiens	4-7
1285482-1	1992	Mononuclear cells in peripheral blood secrete immunoreactive hCG (ir-hCG) when they are stimulated in in-vitro culture with the proteinkinase C - activator phorbol-myristat-acetate (TPA).	Tetradecanoylphorbol Acetate	182-185	chorionic gonadotropin subunit beta 5	Homo sapiens	69-72
1285482-3	1992	Mononuclear cells of pregnant women secrete after TPA stimulation significantly more ir-hCG than mononuclear cells on non-pregnant but fertile women.	Tetradecanoylphorbol Acetate	50-53	chorionic gonadotropin subunit beta 5	Homo sapiens	88-91
1657582-7	1991	In GH3 cells, 1 microM phorbol myristate acetate (PMA), an activator of protein kinase C, inhibited the initial response to TRH by 75 +/- 6% and preexposure to PMA and TRH decreased the rate of PPI hydrolysis by 98 +/- 1% after 60 min.	Tetradecanoylphorbol Acetate	23-48	thyrotropin releasing hormone	Rattus norvegicus	124-127
1662217-9	1991	Tryptic phosphopeptide mapping analysis of the 42- and 44-kDa proteins, respectively, revealed a single major phosphopeptide containing phosphothreonine and phosphotyrosine, which was common to both insulin- and TPA-stimulated phosphoproteins.	Tetradecanoylphorbol Acetate	212-215	insulin	Oryctolagus cuniculus	199-206
1657582-7	1991	In GH3 cells, 1 microM phorbol myristate acetate (PMA), an activator of protein kinase C, inhibited the initial response to TRH by 75 +/- 6% and preexposure to PMA and TRH decreased the rate of PPI hydrolysis by 98 +/- 1% after 60 min.	Tetradecanoylphorbol Acetate	23-48	thyrotropin releasing hormone	Rattus norvegicus	168-171
1657582-7	1991	In GH3 cells, 1 microM phorbol myristate acetate (PMA), an activator of protein kinase C, inhibited the initial response to TRH by 75 +/- 6% and preexposure to PMA and TRH decreased the rate of PPI hydrolysis by 98 +/- 1% after 60 min.	Tetradecanoylphorbol Acetate	50-53	thyrotropin releasing hormone	Rattus norvegicus	124-127
1657582-7	1991	In GH3 cells, 1 microM phorbol myristate acetate (PMA), an activator of protein kinase C, inhibited the initial response to TRH by 75 +/- 6% and preexposure to PMA and TRH decreased the rate of PPI hydrolysis by 98 +/- 1% after 60 min.	Tetradecanoylphorbol Acetate	50-53	thyrotropin releasing hormone	Rattus norvegicus	168-171
1345920-8	1992	Finally, IL-4 production could only be induced by stimulation with PMA and ionomycin in either resting or activated CD31- CD4 cells.	Tetradecanoylphorbol Acetate	67-70	platelet and endothelial cell adhesion molecule 1	Homo sapiens	116-120
1765095-7	1991	12-O-Tetradecanoylphorbol 13-acetate was found to inhibit rapidly and potently the expression of mRNAs coding for the myogenic regulators CMD1 and myogenin.	Tetradecanoylphorbol Acetate	0-36	myogenin	Gallus gallus	147-155
1733630-5	1992	The IL-2R beta chain is constitutively expressed on freshly isolated thymocytes; this expression can be increased in thymocytes activated with Con A in combination with IL-2 or tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	210-213	interleukin 2 receptor subunit beta	Homo sapiens	4-14
1733630-7	1992	The accumulation of IL-2R-beta-specific mRNA is observed in freshly isolated thymocytes and it is increased in thymocytes cultured with rIL-2 alone, with Con A, and further enhanced by the addition of rIL-2 in combination with Con A or with TPA.	Tetradecanoylphorbol Acetate	241-244	interleukin 2 receptor subunit beta	Homo sapiens	20-25
1655898-4	1991	The selective inhibition of ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine biosynthesis, during PMA and ionomycin-induction of B cell cycle progression, inhibits the expression of CK II activity.	Tetradecanoylphorbol Acetate	119-122	ornithine decarboxylase 1	Homo sapiens	28-51
1655898-4	1991	The selective inhibition of ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine biosynthesis, during PMA and ionomycin-induction of B cell cycle progression, inhibits the expression of CK II activity.	Tetradecanoylphorbol Acetate	119-122	ornithine decarboxylase 1	Homo sapiens	53-56
1719463-5	1991	The myc protein synthesized following 1-2 h of anti-immunoglobulin or TPA treatment migrates more slowly in a polyacrylamide gel as a result of increased phosphorylation.	Tetradecanoylphorbol Acetate	70-73	myelocytomatosis oncogene	Mus musculus	4-7
1742484-0	1991	Aphidicolin, an inhibitor of DNA replication, blocks the TPA-induced differentiation of a human megakaryoblastic cell line, MEG-O1.	Tetradecanoylphorbol Acetate	57-60	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	124-127
1719463-9	1991	By 8 h of GaMIg or TPA treatment, a hypophosphorylated form begins to be detectable and significant levels were seen by 15 h. Thus post-translational control of both c-myc and RB expression occurs during the growth arrest of WEHI 231 cells.	Tetradecanoylphorbol Acetate	19-22	myelocytomatosis oncogene	Mus musculus	168-171
1740102-5	1992	We report here that the 150 bp region upstream of the first initiation site of RNA transcribed from the murine germ-line C gamma 1 gene, contains promoter and enhancer elements responsible for basal level transcription and inducibility by anti-Ig phorbol myristate acetate (PMA) and for synergy of these inducers with IL-4 in a surface IgM+ B cell line, L10A6.2 and a surface IgG2a+ B cell line, A20.3.	Tetradecanoylphorbol Acetate	247-272	T cell receptor gamma, constant 1	Mus musculus	121-130
1371491-8	1992	When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha.	Tetradecanoylphorbol Acetate	49-80	interleukin 5	Homo sapiens	206-210
1371491-8	1992	When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha.	Tetradecanoylphorbol Acetate	82-85	interleukin 5	Homo sapiens	206-210
1537597-0	1992	Expression of interleukin-5 and granulocyte-macrophage colony-stimulating factor in human peripheral blood mononuclear cells after activation with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	147-172	interleukin 5	Homo sapiens	14-27
1681733-7	1991	The protein kinase C agonist, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a known stimulator of psoriasiform cutaneous inflammation when applied directly to murine epidermis, strongly induced keratinocyte elaboration of IL-8 mRNA.	Tetradecanoylphorbol Acetate	30-67	chemokine (C-X-C motif) ligand 15	Mus musculus	221-225
1681733-7	1991	The protein kinase C agonist, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a known stimulator of psoriasiform cutaneous inflammation when applied directly to murine epidermis, strongly induced keratinocyte elaboration of IL-8 mRNA.	Tetradecanoylphorbol Acetate	69-72	chemokine (C-X-C motif) ligand 15	Mus musculus	221-225
1742484-1	1991	The commitment process of a human megakaryoblastic cell line (MEG-O1) induced with phorbol ester, TPA, was investigated with special reference to glycoprotein (GP) IIb/IIIa expression, multinuclear formation, and DNA replication.	Tetradecanoylphorbol Acetate	98-101	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	62-65
1742484-2	1991	TPA (10(-7) mol/L) completely inhibited cellular division in MEG-O1, but did not suppress de novo DNA synthesis.	Tetradecanoylphorbol Acetate	0-3	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	61-64
1680163-8	1991	In contrast to VIP and forskolin, 12-O-tetradecanoylphorbol 13-acetate, a phorbol ester known to activate protein kinase C, increased the phosphorylation on a total of three tryptic peptides of TH.	Tetradecanoylphorbol Acetate	34-70	tyrosine hydroxylase	Bos taurus	194-196
1742484-3	1991	Two days" culture with 10(-7) mol/L TPA was sufficient for MEG-O1 cells to initiate an irreversible commitment process.	Tetradecanoylphorbol Acetate	36-39	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	59-62
1742484-8	1991	In TPA-treated cells, the activity of DNA polymerase alpha, a marker for cell growth, remained at the same level as in control cells.	Tetradecanoylphorbol Acetate	3-6	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	38-58
1662913-4	1991	TNF also primed the liver to generate more superoxide anion (2.0 nmol.min-1.g-1) in response to an in vitro challenge with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	123-154	tumor necrosis factor-like	Rattus norvegicus	0-3
1655042-2	1991	Phorbol myristate acetate (PMA) induced PAI-1 in these cells implicating the protein kinase C (PK-C) pathway.	Tetradecanoylphorbol Acetate	0-25	serpin family E member 1	Bos taurus	40-45
1655042-2	1991	Phorbol myristate acetate (PMA) induced PAI-1 in these cells implicating the protein kinase C (PK-C) pathway.	Tetradecanoylphorbol Acetate	27-30	serpin family E member 1	Bos taurus	40-45
1530793-10	1992	In EL-4 cells, IL-1 potentiates PMA-mediated release of IL-2 at suboptimal concentrations of PMA.	Tetradecanoylphorbol Acetate	32-35	interleukin 1 complex	Mus musculus	15-19
1530793-10	1992	In EL-4 cells, IL-1 potentiates PMA-mediated release of IL-2 at suboptimal concentrations of PMA.	Tetradecanoylphorbol Acetate	93-96	interleukin 1 complex	Mus musculus	15-19
1774959-4	1991	On the other hand, the protein kinase C agonist, TPA, strongly activated c-jun expression but poorly promoted expression (transcription) of c-myc in FDC-P1.	Tetradecanoylphorbol Acetate	49-52	jun proto-oncogene	Mus musculus	73-78
1445621-0	1992	Role of activator protein-1 and methylation function in 12-O-tetradecanoylphorbol-13-acetate--mediated inhibition of differentiation of Friend erythroleukemia cells.	Tetradecanoylphorbol Acetate	56-92	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	8-27
1445622-0	1992	12-O-tetradecanoylphorbol-13-acetate--induced levels of AP-1 proteins: a 46-kDa protein immunoprecipitated by anti-fra-1 and induced in promotion-resistant but not promotion-sensitive JB6 cells.	Tetradecanoylphorbol Acetate	0-36	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	56-60
1445622-4	1992	In this investigation, steady-state levels of AP-1 protein components were measured by immunoprecipitating proteins from 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated P+ and P- cells to discern what may limit the AP-1 response.	Tetradecanoylphorbol Acetate	121-157	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	46-50
1445622-4	1992	In this investigation, steady-state levels of AP-1 protein components were measured by immunoprecipitating proteins from 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated P+ and P- cells to discern what may limit the AP-1 response.	Tetradecanoylphorbol Acetate	159-162	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	46-50
1723278-3	1991	The combination of concanavalin A (Con A), tetradecanoylphorbol acetate (TPA), and IL-2 was shown to be the most reliable stimulus for the proliferation of CD3-CD1- thymocytes for up to 15 days in a culture system in vitro.	Tetradecanoylphorbol Acetate	43-71	CD1c molecule	Homo sapiens	160-163
1723278-3	1991	The combination of concanavalin A (Con A), tetradecanoylphorbol acetate (TPA), and IL-2 was shown to be the most reliable stimulus for the proliferation of CD3-CD1- thymocytes for up to 15 days in a culture system in vitro.	Tetradecanoylphorbol Acetate	73-76	CD1c molecule	Homo sapiens	160-163
1445622-4	1992	In this investigation, steady-state levels of AP-1 protein components were measured by immunoprecipitating proteins from 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated P+ and P- cells to discern what may limit the AP-1 response.	Tetradecanoylphorbol Acetate	159-162	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	218-222
1928327-3	1991	Prior exposure to the calmodulin antagonists calmidazolium (3 and 10 microM) and W-7 (10 microM) inhibited contractions to PMA in the presence and absence of extracellular Ca2+, while contractions to norepinephrine and KCl remained relatively unaffected.	Tetradecanoylphorbol Acetate	123-126	calmodulin 1	Rattus norvegicus	22-32
1581617-5	1992	Additional studies showed that P180 was greatly increased in both plasma membranes and endoplasmic reticulum in sensitive cells induced to differentiate in the presence of 12-O-tetradecanoylphorbol13-acetate (TPA).	Tetradecanoylphorbol Acetate	172-207	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	31-35
1581617-5	1992	Additional studies showed that P180 was greatly increased in both plasma membranes and endoplasmic reticulum in sensitive cells induced to differentiate in the presence of 12-O-tetradecanoylphorbol13-acetate (TPA).	Tetradecanoylphorbol Acetate	209-212	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	31-35
1861152-6	1991	Finally, when PC12 cells were rendered PKC-deficient by treatment with 1 muM TPA for 24 h, NGF maintained the ability to induce an increase in NF-M phosphorylation, though not to the level attained in cells which were not PKC-deficient.	Tetradecanoylphorbol Acetate	77-80	nerve growth factor	Rattus norvegicus	91-94
1653025-7	1991	The apparent disappearance of PKC histone-kinase activity induced by TPA was also observed using other substrates (protamine or vinculin).	Tetradecanoylphorbol Acetate	69-72	vinculin	Rattus norvegicus	128-136
1722214-7	1991	Two different sequences involved in mediating TPA-induced transcription of the urokinase plasminogen activator and of the c-jun gene, respectively, competed for proteins with affinity toward the VLX binding site.	Tetradecanoylphorbol Acetate	46-49	jun proto-oncogene	Mus musculus	122-127
1928327-6	1991	These results suggest that 1) the calmodulin antagonists inhibit the development of PMA-induced contraction, at least in part, through inhibition of PKC translocation; 2) the mechanisms of phorbol ester- and agonist-induced translocation of PKC are distinct; 3) the potencies and inhibitory mechanisms of these agents depend on whether the agents are added before or during the contraction; and 4) the selectivity of these agents, as evaluated in enzyme preparations, may not be consistent with their cellular actions.	Tetradecanoylphorbol Acetate	84-87	calmodulin 1	Rattus norvegicus	34-44
1662913-4	1991	TNF also primed the liver to generate more superoxide anion (2.0 nmol.min-1.g-1) in response to an in vitro challenge with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	156-159	tumor necrosis factor-like	Rattus norvegicus	0-3
1662913-5	1991	Kupffer cells are most likely responsible for the superoxide anion production under these conditions, because the isolated Kupffer cells from TNF-infused rats produced increased quantities of superoxide anion (4-8 nmol/10(6) cells) when subsequently treated in vitro with either PMA or opsonized zymosan (control less than 1 nmol/10(6) cells).	Tetradecanoylphorbol Acetate	279-282	tumor necrosis factor-like	Rattus norvegicus	142-145
2061319-8	1991	Although phorbol myristate acetate (PMA), ionomycin, PMA + ionomycin, and 8-bromo-cyclic AMP had no significant effect on the activity, a 5-min preincubation with PMA potentiated the activation of G6PD by PDGF.	Tetradecanoylphorbol Acetate	9-34	glucose-6-phosphate dehydrogenase	Rattus norvegicus	197-201
1678698-6	1991	Potentiation by phorbol 12-myristate 13-acetate of forskolin-stimulated GHRH and SS release was observed.	Tetradecanoylphorbol Acetate	16-47	growth hormone releasing hormone	Rattus norvegicus	72-76
1715315-3	1991	In contrast, aggregate formation by B cells activated with phorbol myristate acetate (PMA) was only partially inhibited by anti-LFA-1 antibody, and those formed in response to PMA plus CD19 antibody were not inhibited at all, suggesting aggregation of activated B cells stimulated with CD19 antibody was LFA-1 independent.	Tetradecanoylphorbol Acetate	59-84	integrin subunit alpha L	Homo sapiens	128-133
1715315-3	1991	In contrast, aggregate formation by B cells activated with phorbol myristate acetate (PMA) was only partially inhibited by anti-LFA-1 antibody, and those formed in response to PMA plus CD19 antibody were not inhibited at all, suggesting aggregation of activated B cells stimulated with CD19 antibody was LFA-1 independent.	Tetradecanoylphorbol Acetate	86-89	integrin subunit alpha L	Homo sapiens	128-133
1656202-6	1991	After phorbol myristate acetate (PMA)-cell stimulation, cytochrome b was mobilized to fractions showing respiratory burst activity and enriched in 5"-nucleotidase activity.	Tetradecanoylphorbol Acetate	33-36	5'-nucleotidase ecto	Homo sapiens	147-162
1836784-7	1991	At Ex-1 the in vitro mitogenic response to concanavalin A, phorbol myristate acetate + ionomycin, phytohemagglutinin, and pokeweed mitogen decreased (P less than 0.05) but returned to levels not different from C at Rec-1.	Tetradecanoylphorbol Acetate	59-84	FERM domain containing 6	Homo sapiens	3-7
2062642-1	1991	cyr61 is an immediate early gene that is transcriptionally activated in 3T3 fibroblasts by serum, platelet-derived growth factor, fibroblast growth factor, and the tumor promoter TPA with kinetics similar to the induction of c-fos.	Tetradecanoylphorbol Acetate	179-182	jun proto-oncogene	Mus musculus	12-27
1725515-5	1991	Triiodothyronine reduced (P less than 0.05) GH release (ng/ml) in response to (1) GRF; (2) the adenylyl cyclase stimulator, forskolin; (3) the cAMP analog and protein kinase A activator, 8-bromo cAMP; and (4) the phorbol ester and protein kinase C activator, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	259-290	growth hormone	Gallus gallus	44-46
1774959-9	1991	In addition, TPA mediated expression of the transfected c-myc gene in FDMT myc.A1 was accompanied by augmented transcription of c-jun and c-fos in response to TPA.	Tetradecanoylphorbol Acetate	13-16	jun proto-oncogene	Mus musculus	128-133
1774959-9	1991	In addition, TPA mediated expression of the transfected c-myc gene in FDMT myc.A1 was accompanied by augmented transcription of c-jun and c-fos in response to TPA.	Tetradecanoylphorbol Acetate	159-162	jun proto-oncogene	Mus musculus	128-133
1652466-4	1991	Interleukin-2 was ineffective in promoting either cell proliferation or enhanced opioid binding, but the effects of IL-1 could be mimicked by phorbol myristate acetate (PMA), suggesting the involvement of tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	142-167	interleukin 1 complex	Mus musculus	116-120
1657981-6	1991	In conclusion, 1) TPA-induced inhibition of insulin receptor tyrosine autophosphorylation was linked to concomitant inhibition of the biological effects of insulin in cells expressing either wild-type or COOH-terminal truncated insulin receptors; and 2) the inhibitory effects of TPA were not dependent upon phosphorylation of COOH-terminal residues and furthermore appeared to be independent of phosphorylation of any insulin receptor serine/threonine residues.	Tetradecanoylphorbol Acetate	280-283	insulin receptor	Homo sapiens	44-60
1889509-7	1991	Addition of PMA at a concentration of 100 ng/ml into the medium caused an increase in the cellular and medium levels of hCG alpha, hCG beta and hCG shortly (3h) after the exposure to PMA.	Tetradecanoylphorbol Acetate	12-15	chorionic gonadotropin subunit beta 5	Homo sapiens	120-123
1889509-7	1991	Addition of PMA at a concentration of 100 ng/ml into the medium caused an increase in the cellular and medium levels of hCG alpha, hCG beta and hCG shortly (3h) after the exposure to PMA.	Tetradecanoylphorbol Acetate	183-186	chorionic gonadotropin subunit beta 5	Homo sapiens	120-123
1652466-4	1991	Interleukin-2 was ineffective in promoting either cell proliferation or enhanced opioid binding, but the effects of IL-1 could be mimicked by phorbol myristate acetate (PMA), suggesting the involvement of tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	169-172	interleukin 1 complex	Mus musculus	116-120
1782669-7	1991	Induction of c-fos and c-myc occurred at both temperatures after the stimulation with FBS, TPA or A23187.	Tetradecanoylphorbol Acetate	91-94	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	23-28
1905019-2	1991	Functional activation of transcriptional factor c-Jun/AP-1 is believed to play an important role in signal transduction of phorbol 12-myristate 13-acetate-induced tumor promotion.	Tetradecanoylphorbol Acetate	123-154	jun proto-oncogene	Mus musculus	48-53
1905019-2	1991	Functional activation of transcriptional factor c-Jun/AP-1 is believed to play an important role in signal transduction of phorbol 12-myristate 13-acetate-induced tumor promotion.	Tetradecanoylphorbol Acetate	123-154	jun proto-oncogene	Mus musculus	54-58
2036974-3	1991	Phorbol esters (phorbol 12-myristate 13-acetate and phorbol 12,13-didecanoate) stimulated PLP secretion at 10(-7)-10(-5) M, whereas forskolin treatment had no effect.	Tetradecanoylphorbol Acetate	16-47	parathyroid hormone like hormone	Homo sapiens	90-93
1893970-9	1991	In contrast, CMK11-5 cells were found to contain mRNA for GPIIb and PF4, and their mRNA levels were increased by the addition of TPA.	Tetradecanoylphorbol Acetate	129-132	platelet factor 4	Homo sapiens	68-71
1723145-0	1991	Thyrotropin-releasing hormone (TRH) and phorbol myristate acetate decrease TRH receptor messenger RNA in rat pituitary GH3 cells: evidence that protein kinase-C mediates the TRH effect.	Tetradecanoylphorbol Acetate	40-65	thyrotropin releasing hormone	Rattus norvegicus	75-78
1723145-0	1991	Thyrotropin-releasing hormone (TRH) and phorbol myristate acetate decrease TRH receptor messenger RNA in rat pituitary GH3 cells: evidence that protein kinase-C mediates the TRH effect.	Tetradecanoylphorbol Acetate	40-65	thyrotropin releasing hormone	Rattus norvegicus	75-78
1723145-4	1991	A maximally effective dose of PMA (1 microM) caused decreases in TRH-R mRNA that were similar in magnitude and time course to those induced by 1 microM TRH.	Tetradecanoylphorbol Acetate	30-33	thyrotropin releasing hormone	Rattus norvegicus	65-68
1712772-1	1991	TIS10 is a primary response gene whose cDNA was cloned as a result of its rapid, superinducible expression in Swiss 3T3 cells in response to 12-O-Tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	141-177	prostaglandin-endoperoxide synthase 2	Mus musculus	0-5
1655042-6	1991	Agents which increase cAMP, (e.g., forskolin and isobutylmethylxanthine) blocked the induction of PAI-1 synthesis by PMA, LPS, TGF beta and TNF alpha suggesting that induction may occur by lowering cAMP.	Tetradecanoylphorbol Acetate	117-120	serpin family E member 1	Bos taurus	98-103
19912806-0	1991	Variation in the composition of the AP1 complex in PC12 cells following induction by NGF and TPA.	Tetradecanoylphorbol Acetate	93-96	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	36-39
19912806-6	1991	The AP1 binding activity can be further induced in all PC12 cells studied by NGF or TPA.	Tetradecanoylphorbol Acetate	84-87	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	4-7
19912806-7	1991	The analysis of c-jun, c-fos, and the fos-related antigens that can constitute the AP1 complex demonstrated compositional variation of this complex by passage in culture and by exposure to NGF or TPA.	Tetradecanoylphorbol Acetate	196-199	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-86
1654122-3	1991	Longer term incubation with TPA caused loss of connexin 43 protein.	Tetradecanoylphorbol Acetate	28-31	gap junction protein alpha 1	Homo sapiens	47-58
2038753-2	1991	Similar to 12-O-tetradecanoylphorbol-13-acetate (TPA), a known tumor promoter, heptachlor induced cell adherence and formation of extended cytoplasmic pseudopodia in ML-1 cells.	Tetradecanoylphorbol Acetate	49-52	interleukin 17F	Homo sapiens	166-170
1712772-9	1991	The TIS10 gene is rapidly and transiently induced by forskolin and serum, as well as by 12-O-tetradecanoylphorbol-13-acetate, in Swiss 3T3 cells.	Tetradecanoylphorbol Acetate	88-124	prostaglandin-endoperoxide synthase 2	Mus musculus	4-9
1829461-7	1991	In contrast to intact cells, purified uPA receptor (isolated from phorbol 12-myristate 13-acetate-stimulated U937 cells) was observed to partially inhibit uPA-catalyzed Plg activation, although activity against low molecular weight substrates was retained.	Tetradecanoylphorbol Acetate	66-97	plasminogen	Homo sapiens	169-172
1903108-11	1991	While the inactive phorbol ester 4 alpha-phorbol 12,13-didecanoate did not modulate the hepatic actions of EGF, activation of protein kinase C by 4 beta-phorbol 12-myristate 13-acetate (70 nM) abolished the ability of EGF to stimulate gluconeogenesis, tricarboxylic acid cycle activity and metabolic flux through the 2-oxoglutarate dehydrogenase complex.	Tetradecanoylphorbol Acetate	148-184	epidermal growth factor like 1	Rattus norvegicus	218-221
1651842-10	1991	Lastly, the phorbol ester phorbol 12-myristate 13-acetate increased the level of the four protooncogene mRNAs, and its effects on c-fos and c-myc were significantly higher than those produced by hCG.	Tetradecanoylphorbol Acetate	26-57	chorionic gonadotropin subunit beta 5	Homo sapiens	195-198
1854615-16	1991	These data indicate that in the post-operative follow-up of breast cancer patients, TPA is the most useful tumour marker and TPA-CA15-3 the most suitable association.	Tetradecanoylphorbol Acetate	125-128	mucin 1, cell surface associated	Homo sapiens	129-135
1936914-6	1991	PMA (25-400 nM) alone and A23187 (250-4000 nM) alone inhibit the stimulatory actions of hCG on T production.	Tetradecanoylphorbol Acetate	0-3	chorionic gonadotropin subunit beta 5	Homo sapiens	88-91
2015601-5	1991	Activators of protein kinase C also afforded protection, and TGF-beta acted synergistically with either phorbol 12-myristate 13-acetate or the calcium ionophore A-23187.	Tetradecanoylphorbol Acetate	104-135	transforming growth factor, beta 1	Mus musculus	61-69
2015601-6	1991	TGF-beta-induced protection against TNF was observed in cells subjected to prolonged treatment with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	100-131	transforming growth factor, beta 1	Mus musculus	0-8
1827482-3	1991	Of 14 phosphoproteins found whose level of phosphorylation was increased (at least fivefold) by anti-CD3 epsilon antibody, 13 also responded to the mixture of PMA and ionomycin.	Tetradecanoylphorbol Acetate	159-162	CD3 antigen, epsilon polypeptide	Mus musculus	101-104
1850355-8	1991	This lack of IGF-I effect is not due to an alteration inherent to the Glut-1 system, since 12-O-tetradecanoyl-phorbol-13-acetate stimulated [3H]dGlc uptake and Glut-1 protein and its mRNA levels.	Tetradecanoylphorbol Acetate	91-128	solute carrier family 2 member 1	Rattus norvegicus	160-166
1714585-5	1991	Furthermore, thapsigargin could synergize with the tumor promoter phorbol 12-myristate 13-acetate to induce c-fos but not c-jun.	Tetradecanoylphorbol Acetate	66-97	jun proto-oncogene	Mus musculus	122-127
1650350-7	1991	In vitro binding studies have demonstrated that the via CD28-induced signal synergizes with either phorbol myristate acetate or anti-CD3 for the induction of a nuclear factor that binds CD28RE and the human immunodeficiency virus (HIV-1) NF-kB motif.	Tetradecanoylphorbol Acetate	99-124	CD28 molecule	Homo sapiens	56-60
1650350-7	1991	In vitro binding studies have demonstrated that the via CD28-induced signal synergizes with either phorbol myristate acetate or anti-CD3 for the induction of a nuclear factor that binds CD28RE and the human immunodeficiency virus (HIV-1) NF-kB motif.	Tetradecanoylphorbol Acetate	99-124	CD28 molecule	Homo sapiens	186-190
2013763-6	1991	Addition of phorbol 12-myristate 13-acetate, a phorbol ester, together with phosphatidylserine, stimulated the phosphorylation of the approximately 20K Mr protein in the hypo-osmotically shocked P2 synaptosomal fraction by fivefold, whereas cyclic AMP, cyclic GMP, and calmodulin did not have any effect on the phosphorylation of this particular protein.	Tetradecanoylphorbol Acetate	12-43	calmodulin 1	Rattus norvegicus	269-279
1901233-6	1991	The IL-9 gene is constitutively expressed in the HTLV-I-transformed human T cells and the expression of IL-9 in these cells can be further induced by 12-O-tetradecanoyl phorbol 13-acetate.	Tetradecanoylphorbol Acetate	150-187	interleukin 9	Homo sapiens	4-8
1907694-5	1991	Phorbol myristate acetate which is known to be protein kinase C (PKC) activator induced IL-2R on monocytes, and PKC inhibitor, H7, inhibited IFN-gamma-induced IL-2R on monocytes in healthy controls.	Tetradecanoylphorbol Acetate	0-25	interleukin 2 receptor subunit alpha	Homo sapiens	88-93
1647880-3	1991	Along this line, we found that CD28 surface expression could be induced within 18 hr on CD3-CD28- thymocytes using very low doses of phorbol-13-myristate-12-acetate (PMA).	Tetradecanoylphorbol Acetate	166-169	CD28 molecule	Homo sapiens	31-35
1647880-3	1991	Along this line, we found that CD28 surface expression could be induced within 18 hr on CD3-CD28- thymocytes using very low doses of phorbol-13-myristate-12-acetate (PMA).	Tetradecanoylphorbol Acetate	166-169	CD28 molecule	Homo sapiens	92-96
1830601-3	1991	For TCR-alpha beta-bearing CD4+8+ and CD4+8low thymocytes that are actively engaged in positive and negative selection processes, negligible to low levels of IL-2 production and cell proliferation were observed in response to TCR:CD3 triggering or to the combined activation of protein kinase C and calcium mobilization mediated by PMA and ionomycin, respectively.	Tetradecanoylphorbol Acetate	332-335	T cell receptor alpha constant	Homo sapiens	4-13
1901233-6	1991	The IL-9 gene is constitutively expressed in the HTLV-I-transformed human T cells and the expression of IL-9 in these cells can be further induced by 12-O-tetradecanoyl phorbol 13-acetate.	Tetradecanoylphorbol Acetate	150-187	interleukin 9	Homo sapiens	104-108
1830601-4	1991	For CD4-8- TCR-alpha beta early thymocytes that have not yet entered the selection process, PMA + ionomycin induced significant cell proliferation but little IL-2 production, in the absence of added IL-1.	Tetradecanoylphorbol Acetate	92-95	T cell receptor alpha constant	Homo sapiens	11-20
2018470-4	1991	The PMA-induced stimulation of both transport and transporter translocation was substantially less than that induced by insulin in this cell line; the PMA-induced increase in plasma-membrane GLUT 1 and GLUT 4 transporter isoforms was only about 40% and 10% respectively of that induced by insulin.	Tetradecanoylphorbol Acetate	151-154	solute carrier family 2 member 4	Homo sapiens	202-208
1711471-2	1991	Recently, however, we were able to show that K13 is aberrantly but constitutively expressed without its normal type II partner K4 also in differentiating parts of 7,12-dimethylbenz(a)anthracene (DMBA/TPA) 12-O-tetradecanoylphorbol-13-acetate-induced squamous cell carcinomas of mouse back skin, whereas its likewise suprabasal expression in papillomas is variable (Nischt et al., Mol.	Tetradecanoylphorbol Acetate	205-241	keratin 13	Mus musculus	45-48
1848559-6	1991	Using the PKC activator phorbol myristate acetate (PMA) as the agonist, we found that activation of the respiratory burst oxidase was associated with translocation of cytosolic p47-phox and p67-phox to the plasma membrane as well as redistribution of p47-phox to the Triton-insoluble cytoskeleton.	Tetradecanoylphorbol Acetate	24-49	neutrophil cytosolic factor 2	Homo sapiens	190-198
1848559-6	1991	Using the PKC activator phorbol myristate acetate (PMA) as the agonist, we found that activation of the respiratory burst oxidase was associated with translocation of cytosolic p47-phox and p67-phox to the plasma membrane as well as redistribution of p47-phox to the Triton-insoluble cytoskeleton.	Tetradecanoylphorbol Acetate	51-54	neutrophil cytosolic factor 2	Homo sapiens	190-198
1907204-10	1991	Stimulation of [32P]-prelabeled fibroblasts with serum, BK, vasopressin, or 12-O-tetradecanoyl phorbol acetate, but not epidermal growth factor or calcium ionophores, resulted in the rapid phosphorylation of MARCKS.	Tetradecanoylphorbol Acetate	76-110	myristoylated alanine rich protein kinase C substrate	Homo sapiens	208-214
1847859-7	1991	In fetal cultures TPA slightly increased P450scc, P450c11, and P450c21 mRNA levels, whereas it decreased P450c17 mRNA.	Tetradecanoylphorbol Acetate	18-21	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	105-112
1886882-6	1991	The transcriptional inhibitor actinomycin D (Act D) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), mimicked the actions of EGF and TGF-alpha.	Tetradecanoylphorbol Acetate	75-112	transforming growth factor alpha	Homo sapiens	152-161
1886882-6	1991	The transcriptional inhibitor actinomycin D (Act D) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), mimicked the actions of EGF and TGF-alpha.	Tetradecanoylphorbol Acetate	114-117	transforming growth factor alpha	Homo sapiens	152-161
1880999-4	1991	The first peak of ODC induction was suppressed by a potent protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	87-123	ornithine decarboxylase 1	Homo sapiens	18-21
2001409-11	1991	The 45Ca2+ influx elicited by Bric 54 exhibited a sensitivity towards inhibition by DIDS and TPA, as well as a dependence on the cation composition of the incubation medium similar to that observed with UEA1.	Tetradecanoylphorbol Acetate	93-96	ATPase phospholipid transporting 8B1	Homo sapiens	30-34
1880999-4	1991	The first peak of ODC induction was suppressed by a potent protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	125-128	ornithine decarboxylase 1	Homo sapiens	18-21
2032553-1	1991	Treatment of neutrophils with phorbol myristate acetate (PMA) increases surface expression of CR3 (iC3b-receptor; CD11b/CD18).	Tetradecanoylphorbol Acetate	30-55	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	94-97
2032553-1	1991	Treatment of neutrophils with phorbol myristate acetate (PMA) increases surface expression of CR3 (iC3b-receptor; CD11b/CD18).	Tetradecanoylphorbol Acetate	57-60	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	94-97
1996318-8	1991	In addition, the 9E3 3" untranslated region increased the response to serum and the tumor promoter phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	99-130	interleukin 8-like 2	Gallus gallus	17-20
2026453-1	1991	The role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied.	Tetradecanoylphorbol Acetate	12-37	interleukin 2 receptor subunit alpha	Homo sapiens	143-165
2026453-1	1991	The role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied.	Tetradecanoylphorbol Acetate	12-37	interleukin 2 receptor subunit alpha	Homo sapiens	167-171
2026453-1	1991	The role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied.	Tetradecanoylphorbol Acetate	39-42	interleukin 2 receptor subunit alpha	Homo sapiens	143-165
2026453-1	1991	The role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied.	Tetradecanoylphorbol Acetate	39-42	interleukin 2 receptor subunit alpha	Homo sapiens	167-171
2067850-2	1991	Depleting cells of protein kinase C (PKC) by prolonged exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA), blocked v-Src-induced TIS10 expression, but had no effect on v-Src-induced Egr-1 gene expression.	Tetradecanoylphorbol Acetate	105-108	prostaglandin-endoperoxide synthase 2	Mus musculus	133-138
2048200-6	1991	Depletion of protein kinase C (PKC) activity from cells by pretreatment of Daudi cells with phorbol.12-myristate 13-acetate (PMA) abolished the G0/G1 arrest induced by both CsA and IFN-alpha.	Tetradecanoylphorbol Acetate	125-128	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	173-176
1997162-4	1991	Phorbol myristate acetate reduced expression of c-myc, c-myb, and heat shock protein 70 and enhanced those of macrophage-colony-stimulating factor and c-fms.	Tetradecanoylphorbol Acetate	0-25	colony stimulating factor 1 receptor	Homo sapiens	151-156
1708205-6	1991	Secretion of ACTH in response to cAMP-independent stimulants such as the protein kinase C activator 12-O-tetradecanoylphorbol-13-acetate or the calcium channel agonist BAY K 8644 were blocked by compound 131 as was the secretory response to 8-bromoadenosine 3",5"-cyclic monophosphate.	Tetradecanoylphorbol Acetate	100-136	pro-opiomelanocortin-alpha	Mus musculus	13-17
2059661-5	1991	First, the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) strongly inhibited PMA-induced activation of NF-kappa B in 70Z/3 cells but had no effect on NF-kappa B activated by IL-1 or LPS.	Tetradecanoylphorbol Acetate	109-112	interleukin 1 complex	Mus musculus	206-210
1850068-3	1991	Cells exposed to the tumor promoting phorbol esters (phorbol 12-myristate 13-acetate, phorbol 12,13-dibutyrate or 4-beta-phorbol 12,13-didecanoate) for 12 h differentially activated PNMT mRNA and ProEnk A mRNA expression.	Tetradecanoylphorbol Acetate	53-84	phenylethanolamine N-methyltransferase	Bos taurus	182-186
1988936-5	1991	Nonetheless, when cells are treated with queuine and 6-TG, they maintain the promyelocytic morphology and are capable of being induced down the monocytic pathway by phorbol 12-myristate 13-acetate as indicated by stabilization of c-fms mRNA and cell adherence.	Tetradecanoylphorbol Acetate	165-196	colony stimulating factor 1 receptor	Homo sapiens	230-235
1824823-7	1991	In response to phorbol myristate acetate, platelet factor 4 and beta-thromboglobulin, which were specifically synthesized in the process of megakaryocyte maturation, dramatically increased in UT-7 cells.	Tetradecanoylphorbol Acetate	15-40	pro-platelet basic protein	Homo sapiens	64-84
2005087-5	1991	In contrast, the induction of TIS1 by NGF and TPA is slight and is only just detectable after stimulation by bFGF, but is strong for carbachol.	Tetradecanoylphorbol Acetate	46-49	fibroblast growth factor 2	Rattus norvegicus	109-113
2005087-7	1991	In keeping with this view, bFGF, and to a lesser degree NGF, can elicit a TIS gene response in PC12 cells in which PK-C has been down-regulated with TPA.	Tetradecanoylphorbol Acetate	149-152	fibroblast growth factor 2	Rattus norvegicus	27-31
2016909-5	1991	Titration curves of a McAb, My7, specific for CD13 on HL60 and TPA-treated HL60 (HL60-TPA) cells, were linear between the 10(-1) and 10(-4) dilutions.	Tetradecanoylphorbol Acetate	63-66	alanyl aminopeptidase, membrane	Homo sapiens	46-50
2007178-5	1991	Acyl coenzyme A:cholesterol acyltransferase activity was increased after TPA-induced differentiation of U-937 cells.	Tetradecanoylphorbol Acetate	73-76	carboxylesterase 1	Homo sapiens	0-43
2070686-6	1991	We demonstrate that PBMC, after stimulation with interleukin 2 or phytohaemagglutinin-P/12-O-tetradecanoylphorbol 13-acetate, secrete significant quantities of latent TGF-beta 1.	Tetradecanoylphorbol Acetate	88-124	transforming growth factor, beta 1	Mus musculus	167-177
2016909-6	1991	A difference in the CD13 expression between HL60 and HL60-TPA cells could be detected by both IPA and flow cytometry using My7 at 10(-1)-10(-3) dilutions.	Tetradecanoylphorbol Acetate	58-61	alanyl aminopeptidase, membrane	Homo sapiens	20-24
2174429-9	1990	The duplication of these actions by TPA suggests that protein kinase C is a mediator of EGF action in hepatocytes.	Tetradecanoylphorbol Acetate	36-39	epidermal growth factor like 1	Rattus norvegicus	88-91
1707000-2	1991	Anti-CD19 antibodies inhibit B cell proliferation in response to anti-Ig plus interleukin 4 (IL4), but enhance the response to mitogenic concentrations of either phorbol 12-myristate 13-acetate (PMA) or Epstein-Barr virus.	Tetradecanoylphorbol Acetate	162-193	CD19 molecule	Homo sapiens	5-9
1707000-2	1991	Anti-CD19 antibodies inhibit B cell proliferation in response to anti-Ig plus interleukin 4 (IL4), but enhance the response to mitogenic concentrations of either phorbol 12-myristate 13-acetate (PMA) or Epstein-Barr virus.	Tetradecanoylphorbol Acetate	195-198	CD19 molecule	Homo sapiens	5-9
2249989-9	1990	Actinomycin D completely blocked the rapid decrease in SP-A and SP-B mRNAs caused by the phorbol ester, consistent with the concept that the inhibitory effect of TPA on the surfactant protein mRNAs required continued gene transcription and was not mediated solely by changes in SP-A or SP-B transcription.	Tetradecanoylphorbol Acetate	162-165	surfactant protein A1	Homo sapiens	55-59
2249989-1	1990	Effects of the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), on expression of pulmonary surfactant proteins, SP-A and SP-B, were determined in a human pulmonary adenocarcinoma cell line (H441-4).	Tetradecanoylphorbol Acetate	69-72	surfactant protein A1	Homo sapiens	123-127
2249989-1	1990	Effects of the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), on expression of pulmonary surfactant proteins, SP-A and SP-B, were determined in a human pulmonary adenocarcinoma cell line (H441-4).	Tetradecanoylphorbol Acetate	69-72	surfactant protein B	Homo sapiens	132-136
2249989-9	1990	Actinomycin D completely blocked the rapid decrease in SP-A and SP-B mRNAs caused by the phorbol ester, consistent with the concept that the inhibitory effect of TPA on the surfactant protein mRNAs required continued gene transcription and was not mediated solely by changes in SP-A or SP-B transcription.	Tetradecanoylphorbol Acetate	162-165	surfactant protein B	Homo sapiens	64-68
2249989-2	1990	TPA decreased cellular SP-A content in association with decreased de novo synthesis of SP-A as assessed by [35S]methionine incorporation.	Tetradecanoylphorbol Acetate	0-3	surfactant protein A1	Homo sapiens	23-27
2249989-2	1990	TPA decreased cellular SP-A content in association with decreased de novo synthesis of SP-A as assessed by [35S]methionine incorporation.	Tetradecanoylphorbol Acetate	0-3	surfactant protein A1	Homo sapiens	87-91
2249989-9	1990	Actinomycin D completely blocked the rapid decrease in SP-A and SP-B mRNAs caused by the phorbol ester, consistent with the concept that the inhibitory effect of TPA on the surfactant protein mRNAs required continued gene transcription and was not mediated solely by changes in SP-A or SP-B transcription.	Tetradecanoylphorbol Acetate	162-165	surfactant protein A1	Homo sapiens	278-282
2249989-6	1990	Inhibitory effects of TPA on SP-A synthesis were associated with concomitant decreases in SP-A mRNA.	Tetradecanoylphorbol Acetate	22-25	surfactant protein A1	Homo sapiens	29-33
2249989-9	1990	Actinomycin D completely blocked the rapid decrease in SP-A and SP-B mRNAs caused by the phorbol ester, consistent with the concept that the inhibitory effect of TPA on the surfactant protein mRNAs required continued gene transcription and was not mediated solely by changes in SP-A or SP-B transcription.	Tetradecanoylphorbol Acetate	162-165	surfactant protein B	Homo sapiens	286-290
2249989-6	1990	Inhibitory effects of TPA on SP-A synthesis were associated with concomitant decreases in SP-A mRNA.	Tetradecanoylphorbol Acetate	22-25	surfactant protein A1	Homo sapiens	90-94
2249989-7	1990	Expression of a distinct surfactant protein, SP-B, was also markedly decreased after exposure to TPA.	Tetradecanoylphorbol Acetate	97-100	surfactant protein B	Homo sapiens	45-49
2011401-2	1991	Treating JURKAT cells with the phorbol ester tetradecanoyl phorbol acetate (TPA) inhibited their proliferation and induced expression of the gene for the interleukin 2 receptor alpha chain (IL2R-alpha), consistent with previous reports.	Tetradecanoylphorbol Acetate	76-79	interleukin 2 receptor subunit alpha	Homo sapiens	190-200
2011401-4	1991	In contrast, accumulation of mRNAs for the C-FOS, C-JUN, and EGR-1 genes increased markedly in TPA-treated cells and preceded the induction of IL2R-alpha mRNA.	Tetradecanoylphorbol Acetate	95-98	interleukin 2 receptor subunit alpha	Homo sapiens	143-153
2249989-8	1990	SP-A and SP-B mRNA contents decreased more rapidly after treatment with TPA than after actinomycin D.	Tetradecanoylphorbol Acetate	72-75	surfactant protein A1	Homo sapiens	0-4
2121513-3	1990	Moreover, the sequential activation of the fos, AP-1, and HO genes was observed during this period, with the maximal transcriptional activities after TPA treatment for 0.5, 1, and 1.5 h, respectively.	Tetradecanoylphorbol Acetate	150-153	jun proto-oncogene	Mus musculus	48-52
2249989-8	1990	SP-A and SP-B mRNA contents decreased more rapidly after treatment with TPA than after actinomycin D.	Tetradecanoylphorbol Acetate	72-75	surfactant protein B	Homo sapiens	9-13
2011401-7	1991	Despite sustained expression of C-MYC, BCL2, or the combination of these protooncogenes, TPA continued to inhibit JURKAT cell growth and to induce IL2R expression.	Tetradecanoylphorbol Acetate	89-92	interleukin 2 receptor subunit alpha	Homo sapiens	147-151
1709049-2	1991	However, whereas CD23 expression is increased by several B cell mitogens, including phorbol 12-myristate 13-acetate, Epstein-Barr virus, anti-immunoglobulin (Ig), and IL-4, surface IgM (sIgM) expression is increased only with IL-4, suggesting that expression of each surface antigen is regulated independently.	Tetradecanoylphorbol Acetate	84-115	Fc epsilon receptor II	Homo sapiens	17-21
1700789-12	1990	Phorbol myristate acetate also stimulated hexose transport as well as expression of the GLUT-1 gene and several immediate-early genes in quiescent 3T3-L1 cells.	Tetradecanoylphorbol Acetate	0-25	jun proto-oncogene	Mus musculus	112-127
2121513-5	1990	As the rat HO gene is known to have a TPA-sensitive element in its promoter region, this gene was suggested to be activated by a fos-AP-1 complex protein.	Tetradecanoylphorbol Acetate	38-41	jun proto-oncogene	Mus musculus	133-137
2026453-4	1991	Radiolabeled IL2 binding assays also demonstrated that PMA induced both high-affinity IL2R (HA-IL2R) and low-affinity IL2R (LA-IL2R) on B-CLL cells, but that A23187 did not.	Tetradecanoylphorbol Acetate	55-58	interleukin 2 receptor subunit alpha	Homo sapiens	86-90
2146363-13	1990	In addition, PHA alone or in combination with PMA induced tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) (but not IL-2) production by CD3- thymocytes.	Tetradecanoylphorbol Acetate	46-49	CD3 antigen, epsilon polypeptide	Mus musculus	160-163
2026453-4	1991	Radiolabeled IL2 binding assays also demonstrated that PMA induced both high-affinity IL2R (HA-IL2R) and low-affinity IL2R (LA-IL2R) on B-CLL cells, but that A23187 did not.	Tetradecanoylphorbol Acetate	55-58	interleukin 2 receptor subunit alpha	Homo sapiens	95-99
2026453-4	1991	Radiolabeled IL2 binding assays also demonstrated that PMA induced both high-affinity IL2R (HA-IL2R) and low-affinity IL2R (LA-IL2R) on B-CLL cells, but that A23187 did not.	Tetradecanoylphorbol Acetate	55-58	interleukin 2 receptor subunit alpha	Homo sapiens	95-99
2213017-4	1990	The protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulates the synthesis of both uPA and PAI-1, resulting in a final increase in the plasmin-generating capacity of neuronal cell cultures.	Tetradecanoylphorbol Acetate	37-73	plasminogen	Homo sapiens	165-172
2255409-0	1990	[CA 15-3 associated with CEA and TPA in the follow-up of breast carcinoma].	Tetradecanoylphorbol Acetate	33-36	mucin 1, cell surface associated	Homo sapiens	1-8
2213017-4	1990	The protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulates the synthesis of both uPA and PAI-1, resulting in a final increase in the plasmin-generating capacity of neuronal cell cultures.	Tetradecanoylphorbol Acetate	75-78	plasminogen	Homo sapiens	165-172
2120207-9	1990	The TPA-induced reduction of [3H]phosphatidylcholine was completely blocked by 50 microM sphingosine and 50 microM H-7, inhibitors of protein kinase C. Both sphingosine and H-7 attenuated IGF-I-mediated reduction of [3H]phosphatidylcholine.	Tetradecanoylphorbol Acetate	4-7	insulin-like growth factor 1	Mus musculus	188-193
2026453-4	1991	Radiolabeled IL2 binding assays also demonstrated that PMA induced both high-affinity IL2R (HA-IL2R) and low-affinity IL2R (LA-IL2R) on B-CLL cells, but that A23187 did not.	Tetradecanoylphorbol Acetate	55-58	interleukin 2 receptor subunit alpha	Homo sapiens	95-99
2026453-5	1991	After treatment with PMA, three of five cases did not respond to IL2 even though they expressed HA-IL2R, suggesting impaired signal transduction.	Tetradecanoylphorbol Acetate	21-24	interleukin 2 receptor subunit alpha	Homo sapiens	99-103
1708162-4	1991	As expected, activation of protein kinase C by TPA increased both CD40 and CD43.	Tetradecanoylphorbol Acetate	47-50	CD40 molecule	Homo sapiens	66-70
1708162-10	1991	Complementation of antigen receptor stimulation with TPA or IL-4 increased CD40 during the first 24 h, whereas up-regulation of CD43 did not occur until 24 to 48 h after stimulation.	Tetradecanoylphorbol Acetate	53-56	CD40 molecule	Homo sapiens	75-79
2255409-1	1990	The serum level measurement of CA 15-3 antigen was evaluated in association with CEA and TPA, during the follow-up in mastectomized patients previously affected by breast cancer: 94 patients with metastases and 319 without apparent disease evolution.	Tetradecanoylphorbol Acetate	89-92	mucin 1, cell surface associated	Homo sapiens	31-38
2283681-8	1990	Down-regulation of PKC by overnight incubation with 0.1 or 1 microM TPA produced the converse effect, namely prolonged Ca2+ entry following stimulation with EGF or TGF-alpha.	Tetradecanoylphorbol Acetate	68-71	transforming growth factor alpha	Homo sapiens	164-173
2283681-13	1990	A431 cells treated with higher concentrations of TPA (5 x 10(-8) M) inhibited not only Ca2+ entry but also Ca2+ release due to EGF/TGF-alpha but had no effect on bradykinin-mediated Ca2+ release, suggesting differences in the regulation of the intracellular stores responsive to these two classes of agonists.	Tetradecanoylphorbol Acetate	49-52	transforming growth factor alpha	Homo sapiens	131-140
2255409-7	1990	Our experience shows that CA 15-3 measurement associated with TPA, during the follow-up of patients affected by breast cancer, may be helpful for increasing the predictivity with respect to those patients most likely to develop recurrent disease.	Tetradecanoylphorbol Acetate	62-65	mucin 1, cell surface associated	Homo sapiens	26-33
1698561-4	1990	CD5 upregulation on TPA-sensitive JM cells appears correlated with inhibition of cell growth, blockage in G1 phase, and phenotypic maturation (downregulation of CD7 and CD1 antigens) and seemed to be related to PKC activation since DiC8 (a PKC activator) mimicked this TPA effect and H7 (a PKC inhibitor) partially reduced it.	Tetradecanoylphorbol Acetate	20-23	CD1c molecule	Homo sapiens	169-172
2170982-1	1990	We have identified a 36-base-pair proximal element (-112 to -77 relative to the AUG translation initiation codon) in the epidermal growth factor receptor 5" region that functions as a promoter; mediates inductive responses to epidermal growth factor, phorbol 12-myristate 13-acetate, and cyclic AMP; and acts in an orientation-independent manner.	Tetradecanoylphorbol Acetate	251-282	C-type lectin domain containing 14A	Homo sapiens	121-155
1845931-4	1991	PMA (12-phorbol 13-myristic acid) also induced Raf-1 phosphorylation in MO7 cells, but the resulting alteration in electrophoretic mobility was different than that observed after GM-CSF or IL-3.	Tetradecanoylphorbol Acetate	0-3	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	47-52
1704321-3	1990	TPA was found to lower basal levels of tyrosinase activity in melanoma cells and to reduce tyrosinase levels in cells treated with either MSH (10(-7) M), dibutyryl cAMP (10(-4) M), isobutylmethylxanthine (IBMX, 10(-4) M), or with the potent MSH analogue, [Nle4,D-phe7]-alpha-MSH.	Tetradecanoylphorbol Acetate	0-3	pro-opiomelanocortin-alpha	Mus musculus	269-278
1985890-4	1991	PKC beta was down-regulated following treatment of thymocytes with phorbol 12-myristate acetate (PMA) (2 x 10(-8) M) or ionomycin (0.4 microM).	Tetradecanoylphorbol Acetate	97-100	protein kinase C, beta	Mus musculus	0-8
1985890-10	1991	PMA treatment left the majority of immunoreactive PKC epsilon intact.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, epsilon	Mus musculus	50-61
2398047-9	1990	Both the p76-kinase-catalyzed phosphorylation of histone III-S and the autophosphorylation of the enzyme could be activated by the phorbol ester TPA (or diacylglycerol) plus phosphatidyl serine, but not by calcium plus phosphatidyl serine.	Tetradecanoylphorbol Acetate	145-148	phospholipase B domain containing 2	Mus musculus	9-12
2398047-11	1990	Like PKC, p76-kinase bound TPA with high affinity (KD = 9.6 nM).	Tetradecanoylphorbol Acetate	27-30	phospholipase B domain containing 2	Mus musculus	10-13
1975240-4	1990	Treatment of U-937 cells with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in the presence of mAb to LFA-1 or ICAM-1 antigens yielded cells free from homotypic adhesions but differentiated as evidenced by their decreased proliferation and enhanced capacity for generation of superoxide anion.	Tetradecanoylphorbol Acetate	48-84	integrin subunit alpha L	Homo sapiens	111-116
1892735-4	1991	On the other hand, direct stimulation of protein kinase C with phorbol myristate acetate (PMA) revealed a subnormal stimulation of beta-glucuronidase exocytosis in CF neutrophils.	Tetradecanoylphorbol Acetate	63-88	glucuronidase beta	Homo sapiens	131-149
1892735-4	1991	On the other hand, direct stimulation of protein kinase C with phorbol myristate acetate (PMA) revealed a subnormal stimulation of beta-glucuronidase exocytosis in CF neutrophils.	Tetradecanoylphorbol Acetate	90-93	glucuronidase beta	Homo sapiens	131-149
2167455-2	1990	This gene and the related cellular genes c-jun, jun B and jun D, encode transactivating (or repressing) DNA-binding proteins that form homo- or heterodimeric (Jun-Jun and Jun-Fos) complexes which recognize the AP-1 consensus sequence TGACTCA, a response element that confers sensitivity to the tumour-promoting phorbol ester TPA.	Tetradecanoylphorbol Acetate	325-328	jun proto-oncogene	Mus musculus	41-46
1663808-6	1991	This region contains conserved consensus sequences for a TPA-responsive element (TRE) and cAMP-responsive element (CRE), suggesting that in addition to regulation by RA receptors other transcription factors regulate RAR beta 2 expression in EC cells.	Tetradecanoylphorbol Acetate	57-60	retinoic acid receptor, beta	Mus musculus	216-224
1663527-2	1991	PMN were stimulated by fMet-Leu-Phe (FMLP) or phorbol myristate acetate (PMA) to elicit chemotaxis, extracellular release of beta-glucuronidase (BGL) and superoxide anion (SOA) production.	Tetradecanoylphorbol Acetate	46-71	glucuronidase beta	Homo sapiens	125-143
1698631-6	1990	Phorbol 12-myristate 13-acetate (PMA) augmented the growth inhibitory effects of anti-CD40 on transfectants.	Tetradecanoylphorbol Acetate	0-31	CD40 molecule	Homo sapiens	86-90
1663527-2	1991	PMN were stimulated by fMet-Leu-Phe (FMLP) or phorbol myristate acetate (PMA) to elicit chemotaxis, extracellular release of beta-glucuronidase (BGL) and superoxide anion (SOA) production.	Tetradecanoylphorbol Acetate	73-76	glucuronidase beta	Homo sapiens	125-143
1663527-2	1991	PMN were stimulated by fMet-Leu-Phe (FMLP) or phorbol myristate acetate (PMA) to elicit chemotaxis, extracellular release of beta-glucuronidase (BGL) and superoxide anion (SOA) production.	Tetradecanoylphorbol Acetate	73-76	glucuronidase beta	Homo sapiens	145-148
1698631-6	1990	Phorbol 12-myristate 13-acetate (PMA) augmented the growth inhibitory effects of anti-CD40 on transfectants.	Tetradecanoylphorbol Acetate	33-36	CD40 molecule	Homo sapiens	86-90
1698631-8	1990	PMA augmented the phosphorylation of CD40 in these cells.	Tetradecanoylphorbol Acetate	0-3	CD40 molecule	Homo sapiens	37-41
1834588-3	1991	The evidence that costimulation with PMA can partially overcome the IL2R defect might allow us to localize the cellular defects and rationally design chemotherapeutic agents corrective for these patients" poor p55kDa-IL2R inducibility.	Tetradecanoylphorbol Acetate	37-40	interleukin 2 receptor subunit alpha	Homo sapiens	68-72
1834588-3	1991	The evidence that costimulation with PMA can partially overcome the IL2R defect might allow us to localize the cellular defects and rationally design chemotherapeutic agents corrective for these patients" poor p55kDa-IL2R inducibility.	Tetradecanoylphorbol Acetate	37-40	interleukin 2 receptor subunit alpha	Homo sapiens	217-221
1698631-9	1990	These results indicate that in spite of the growth inhibitory effect of anti-CD40, the augmentative effect of PMA is conserved in CD40+ transfectants and suggest that the transfectant might be useful for the study of signal transduction mechanism through CD40.	Tetradecanoylphorbol Acetate	110-113	CD40 molecule	Homo sapiens	130-134
1698631-9	1990	These results indicate that in spite of the growth inhibitory effect of anti-CD40, the augmentative effect of PMA is conserved in CD40+ transfectants and suggest that the transfectant might be useful for the study of signal transduction mechanism through CD40.	Tetradecanoylphorbol Acetate	110-113	CD40 molecule	Homo sapiens	130-134
2145219-9	1990	Addition of PMA induces both p70/75 and p50/55 IL2 receptor upregulation, as well as IL2-dependent proliferation.	Tetradecanoylphorbol Acetate	12-15	interleukin 2 receptor subunit beta	Homo sapiens	29-35
2145219-9	1990	Addition of PMA induces both p70/75 and p50/55 IL2 receptor upregulation, as well as IL2-dependent proliferation.	Tetradecanoylphorbol Acetate	12-15	CD40 molecule	Homo sapiens	40-43
1985107-2	1991	Two of the cytosolic NADPH oxidase components, p47-phox and p67-phox, translocate to the plasma membrane in normal neutrophils stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	143-168	neutrophil cytosolic factor 2	Homo sapiens	60-68
2194392-7	1990	When stimulated in vitro by anti-mu and TPA, (phorbol ester) tumor cells showed a decrease in CD21 and Slg and a stronger expression of CD25, T9, T10, and PCA1, with evidence of Ig secretion in four out of the seven cases studied.	Tetradecanoylphorbol Acetate	40-43	prostate cancer associated transcript 1	Homo sapiens	155-159
1985107-2	1991	Two of the cytosolic NADPH oxidase components, p47-phox and p67-phox, translocate to the plasma membrane in normal neutrophils stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	170-173	neutrophil cytosolic factor 2	Homo sapiens	60-68
27463048-6	1991	Immunophenotypic analysis showed that TPA induced further differentiation of REH cells along the B-cell lineage as indicated by significant decrease in the expression of CD10, induction of CD11c and increase in the expression of CD22.	Tetradecanoylphorbol Acetate	38-41	integrin subunit alpha X	Homo sapiens	189-194
1694014-6	1990	Treatment of human myeloid cell lines HL-60 and U937 with phorbol 12-myristate 13-acetate (PMA) increased within 2 h cellular levels of the RNA hybridizable to LD78 cDNA.	Tetradecanoylphorbol Acetate	58-89	C-C motif chemokine ligand 3 like 1	Homo sapiens	160-164
1651431-2	1991	Pretreatment of chondrocytes with TPA (10(-8) M) for 48 h significantly enhanced DNA synthesis, inhibited glycosaminoglycan (GAG) synthesis and inhibited the increase in ornithine decarboxylase (ODC) activity in response to parathyroid hormone (PTH) relative to values in control cultures.	Tetradecanoylphorbol Acetate	34-37	parathyroid hormone	Oryctolagus cuniculus	224-243
1651431-2	1991	Pretreatment of chondrocytes with TPA (10(-8) M) for 48 h significantly enhanced DNA synthesis, inhibited glycosaminoglycan (GAG) synthesis and inhibited the increase in ornithine decarboxylase (ODC) activity in response to parathyroid hormone (PTH) relative to values in control cultures.	Tetradecanoylphorbol Acetate	34-37	parathyroid hormone	Oryctolagus cuniculus	245-248
1651431-3	1991	Addition of elastase (1, 10 and 50 ng/ml) for 24 h partially inhibited the de-differentiated phenotypes induced by TPA such as the decreased synthesis of GAG and decreased response of ODC activity to PTH without affecting the DNA synthesis.	Tetradecanoylphorbol Acetate	115-118	parathyroid hormone	Oryctolagus cuniculus	200-203
1694014-6	1990	Treatment of human myeloid cell lines HL-60 and U937 with phorbol 12-myristate 13-acetate (PMA) increased within 2 h cellular levels of the RNA hybridizable to LD78 cDNA.	Tetradecanoylphorbol Acetate	91-94	C-C motif chemokine ligand 3 like 1	Homo sapiens	160-164
1651431-4	1991	Moreover, elastase significantly increased both the basal level of cyclic AMP and that on PTH treatment of TPA-pretreated cells.	Tetradecanoylphorbol Acetate	107-110	parathyroid hormone	Oryctolagus cuniculus	90-93
2138061-3	1990	FACS-purified B220+/Thy1+ lpr lymph node cells showed little proliferative response to cytokines, even in the presence of PMA, and failed to proliferate in response to stimulation through the CD3/TcR complex.	Tetradecanoylphorbol Acetate	122-125	acyl-CoA synthetase long-chain family member 1	Mus musculus	0-4
1646739-5	1991	Phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, increased Ca2+ inflow at a concentration of 10(-9) to 10(-5) M. The presence of CT (10(-8) M) synergistically enhanced PMA-increased Ca2+ inflow at concentrations of 10(-7) to 10(-5) M. The present results suggest that CT can stimulate the rate of Ca2+ inflow in rat liver cells.	Tetradecanoylphorbol Acetate	0-31	calcitonin-related polypeptide alpha	Rattus norvegicus	153-155
1646739-5	1991	Phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, increased Ca2+ inflow at a concentration of 10(-9) to 10(-5) M. The presence of CT (10(-8) M) synergistically enhanced PMA-increased Ca2+ inflow at concentrations of 10(-7) to 10(-5) M. The present results suggest that CT can stimulate the rate of Ca2+ inflow in rat liver cells.	Tetradecanoylphorbol Acetate	0-31	calcitonin-related polypeptide alpha	Rattus norvegicus	292-294
2138707-0	1990	mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element.	Tetradecanoylphorbol Acetate	84-120	jun proto-oncogene	Mus musculus	17-22
1646739-5	1991	Phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, increased Ca2+ inflow at a concentration of 10(-9) to 10(-5) M. The presence of CT (10(-8) M) synergistically enhanced PMA-increased Ca2+ inflow at concentrations of 10(-7) to 10(-5) M. The present results suggest that CT can stimulate the rate of Ca2+ inflow in rat liver cells.	Tetradecanoylphorbol Acetate	33-36	calcitonin-related polypeptide alpha	Rattus norvegicus	153-155
1646739-5	1991	Phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, increased Ca2+ inflow at a concentration of 10(-9) to 10(-5) M. The presence of CT (10(-8) M) synergistically enhanced PMA-increased Ca2+ inflow at concentrations of 10(-7) to 10(-5) M. The present results suggest that CT can stimulate the rate of Ca2+ inflow in rat liver cells.	Tetradecanoylphorbol Acetate	33-36	calcitonin-related polypeptide alpha	Rattus norvegicus	292-294
1646739-5	1991	Phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, increased Ca2+ inflow at a concentration of 10(-9) to 10(-5) M. The presence of CT (10(-8) M) synergistically enhanced PMA-increased Ca2+ inflow at concentrations of 10(-7) to 10(-5) M. The present results suggest that CT can stimulate the rate of Ca2+ inflow in rat liver cells.	Tetradecanoylphorbol Acetate	192-195	calcitonin-related polypeptide alpha	Rattus norvegicus	153-155
2259391-5	1990	In the presence of the concentration of either phorbol ester (PMA, 0.1 mumol/l, PDB 1 mumol/l), that was supramaximal for increasing the release of noradrenaline, NPY (0.3 mumol/l) significantly inhibited the release of noradrenaline.	Tetradecanoylphorbol Acetate	62-65	neuropeptide Y	Mus musculus	163-166
1724371-2	1991	In this study, we investigated v-Ha-ras-induced papillomas for aberrant expression of type I keratin K13, previously described in 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13- acetate (DMBA/TPA)-induced mouse epidermal tumors.	Tetradecanoylphorbol Acetate	161-198	keratin 13	Mus musculus	101-104
1724371-2	1991	In this study, we investigated v-Ha-ras-induced papillomas for aberrant expression of type I keratin K13, previously described in 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13- acetate (DMBA/TPA)-induced mouse epidermal tumors.	Tetradecanoylphorbol Acetate	205-208	keratin 13	Mus musculus	101-104
1724371-8	1991	Thus, all features of aberrant K13 expression previously described in DMBA/TPA-induced papillomas were shared by v-Ha-ras-induced papillomas.	Tetradecanoylphorbol Acetate	75-78	keratin 13	Mus musculus	31-34
1872950-3	1991	We showed that, although levels of glucose transporter and c-myc mRNAs in Rat-1 cells underwent a transient increase within hours of the addition of serum, epidermal growth factor, or 12-O-tetradecanoylphorbol-13-acetate to quiescent (G0) cells, the levels of glucose transporter and c-myc mRNA otherwise remained constant throughout the normal cell cycle.	Tetradecanoylphorbol Acetate	184-220	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	59-64
1872950-3	1991	We showed that, although levels of glucose transporter and c-myc mRNAs in Rat-1 cells underwent a transient increase within hours of the addition of serum, epidermal growth factor, or 12-O-tetradecanoylphorbol-13-acetate to quiescent (G0) cells, the levels of glucose transporter and c-myc mRNA otherwise remained constant throughout the normal cell cycle.	Tetradecanoylphorbol Acetate	184-220	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	284-289
2158466-5	1990	Activation of protein kinase C by a phorbol ester (12-O-tetradecanoylphorbol 13-acetate) increased progesterone receptor levels to a similar extent as EGF or estradiol.	Tetradecanoylphorbol Acetate	51-87	progesterone receptor	Homo sapiens	99-120
2154379-2	1990	The rate of amiloride-sensitive Na(+)-dependent recovery from cytoplasmic-acid-loading was found to be increased in cells treated with epidermal growth factor (EGF), 8-(4-chlorophenylthio)adenosine 3",5"-monophosphate (ClPhScAMP) or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	233-264	epidermal growth factor like 1	Rattus norvegicus	135-158
1844247-3	1991	Analysis of 32P-labelled phosphoproteins indicates that R6-PKC cells display increased phosphorylation of a 80/87 kDa protein (designated MARCKS), and after treatment with TPA they display a dramatic prolongation in the phosphorylation and in the cytosolic accumulation of this protein.	Tetradecanoylphorbol Acetate	172-175	myristoylated alanine rich protein kinase C substrate	Homo sapiens	138-144
1844247-9	1991	Prolonged treatment of R6 cells with TPA caused total loss of cPKC alpha, nPKC delta and nPKC zeta but only a 60% reduction in nPKC epsilon.	Tetradecanoylphorbol Acetate	37-40	protein kinase C delta	Homo sapiens	74-84
2154379-2	1990	The rate of amiloride-sensitive Na(+)-dependent recovery from cytoplasmic-acid-loading was found to be increased in cells treated with epidermal growth factor (EGF), 8-(4-chlorophenylthio)adenosine 3",5"-monophosphate (ClPhScAMP) or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	233-264	epidermal growth factor like 1	Rattus norvegicus	160-163
2154379-2	1990	The rate of amiloride-sensitive Na(+)-dependent recovery from cytoplasmic-acid-loading was found to be increased in cells treated with epidermal growth factor (EGF), 8-(4-chlorophenylthio)adenosine 3",5"-monophosphate (ClPhScAMP) or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	266-269	epidermal growth factor like 1	Rattus norvegicus	135-158
2268359-1	1990	Interleukin 1 (IL-1) has been shown to potentiate the release of beta-endorphin induced by secretagogues, including corticotropin releasing factor (CRF) and phorbol ester (TPA), in the mouse AtT-20 pituitary tumor cell line (Fagarasan et al., PNAS, 1989, 86, 2070-2073).	Tetradecanoylphorbol Acetate	172-175	interleukin 1 complex	Mus musculus	0-13
2154379-2	1990	The rate of amiloride-sensitive Na(+)-dependent recovery from cytoplasmic-acid-loading was found to be increased in cells treated with epidermal growth factor (EGF), 8-(4-chlorophenylthio)adenosine 3",5"-monophosphate (ClPhScAMP) or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	266-269	epidermal growth factor like 1	Rattus norvegicus	160-163
2268359-1	1990	Interleukin 1 (IL-1) has been shown to potentiate the release of beta-endorphin induced by secretagogues, including corticotropin releasing factor (CRF) and phorbol ester (TPA), in the mouse AtT-20 pituitary tumor cell line (Fagarasan et al., PNAS, 1989, 86, 2070-2073).	Tetradecanoylphorbol Acetate	172-175	interleukin 1 complex	Mus musculus	15-19
2306238-5	1990	Contrastingly, proliferating L6 myogenic cells only expressed aFGF mRNA significantly under TPA treatment.	Tetradecanoylphorbol Acetate	92-95	fibroblast growth factor 1	Bos taurus	62-66
2268359-1	1990	Interleukin 1 (IL-1) has been shown to potentiate the release of beta-endorphin induced by secretagogues, including corticotropin releasing factor (CRF) and phorbol ester (TPA), in the mouse AtT-20 pituitary tumor cell line (Fagarasan et al., PNAS, 1989, 86, 2070-2073).	Tetradecanoylphorbol Acetate	172-175	pro-opiomelanocortin-alpha	Mus musculus	65-79
2268359-4	1990	However, treatment of AtT-20 cells with IL-1 induced the expression of vasopressin-mediated beta-endorphin release; this effect of IL-1 was reduced after depletion of protein kinase C by prolonged treatment with TPA.	Tetradecanoylphorbol Acetate	212-215	interleukin 1 complex	Mus musculus	40-44
2268359-4	1990	However, treatment of AtT-20 cells with IL-1 induced the expression of vasopressin-mediated beta-endorphin release; this effect of IL-1 was reduced after depletion of protein kinase C by prolonged treatment with TPA.	Tetradecanoylphorbol Acetate	212-215	pro-opiomelanocortin-alpha	Mus musculus	92-106
2268359-4	1990	However, treatment of AtT-20 cells with IL-1 induced the expression of vasopressin-mediated beta-endorphin release; this effect of IL-1 was reduced after depletion of protein kinase C by prolonged treatment with TPA.	Tetradecanoylphorbol Acetate	212-215	interleukin 1 complex	Mus musculus	131-135
2159522-6	1990	BF suppressed phorbol myristate acetate (PMA)-induced superoxide formation of polymorphonuclear leukocytes (PMNs), protected hypotonic hemolysis of erythrocyte and inhibited platelet aggregation induced by adenosine diphosphate (ADP) and serum phospholipase A activity.	Tetradecanoylphorbol Acetate	14-39	phospholipase A and acyltransferase 1	Rattus norvegicus	244-259
2174435-8	1990	In comparison, 12-O-tetradecanoylphorbol-13-acetate (50 ng/ml, 8 x 10(-8) M), which also stimulates collagenase expression strongly (greater than 30-fold), elevated TIMP protein and mRNA levels (2- and 3-fold, respectively) and did not affect MMP-2 expression.	Tetradecanoylphorbol Acetate	15-51	matrix metallopeptidase 2	Homo sapiens	243-248
1696526-2	1990	We found that CD1+ cells expressed high levels of CD25 antigen upon triggering with specific monoclonal antibodies (mAbs) (anti-CD3, anti-CD2, anti-CD28) in association with low doses of Phorbol-13-myristate-12-acetate (PMA).	Tetradecanoylphorbol Acetate	220-223	CD1c molecule	Homo sapiens	14-17
1696526-2	1990	We found that CD1+ cells expressed high levels of CD25 antigen upon triggering with specific monoclonal antibodies (mAbs) (anti-CD3, anti-CD2, anti-CD28) in association with low doses of Phorbol-13-myristate-12-acetate (PMA).	Tetradecanoylphorbol Acetate	220-223	interleukin 2 receptor subunit alpha	Homo sapiens	50-54
1966891-4	1990	Addition of PMA, guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S), GTP, or thrombin shifted the Ca2+ dose-response curves for secretion of both 5-HT and beta TG to the left and caused small increases in the maximum secretion observed.	Tetradecanoylphorbol Acetate	12-15	pro-platelet basic protein	Homo sapiens	154-161
2118562-6	1990	TPA-treated monocytes survived in larger numbers in culture for up to 7 weeks and were more pleomorphic and exhibited higher beta-galactosidase activities after 14 days in culture than untreated monocytes.	Tetradecanoylphorbol Acetate	0-3	galactosidase beta 1	Homo sapiens	125-143
2159522-6	1990	BF suppressed phorbol myristate acetate (PMA)-induced superoxide formation of polymorphonuclear leukocytes (PMNs), protected hypotonic hemolysis of erythrocyte and inhibited platelet aggregation induced by adenosine diphosphate (ADP) and serum phospholipase A activity.	Tetradecanoylphorbol Acetate	41-44	phospholipase A and acyltransferase 1	Rattus norvegicus	244-259
2329998-7	1990	The effects of IL-1 were mimicked by the tumor promoter phorbol 12-myristate 13-acetate (PMA) at 1-100 nM, which inhibited CDP and reduced procollagen alpha 1(I) mRNA levels to a similar extent.	Tetradecanoylphorbol Acetate	56-87	interleukin 1 complex	Mus musculus	15-19
1696272-9	1990	Phorbol 12-myristate 13-acetate, a reagent known to affect the degranulation of specific granules, causes the release of immunoreactive-PDI into a post-centrifugation supernatant.	Tetradecanoylphorbol Acetate	0-31	prolyl 4-hydroxylase subunit beta	Homo sapiens	136-139
2115328-0	1990	Murine T-cell differentiation antigen CD8 is a direct substrate of protein kinase C. Murine T cell differentiation antigen CD8 alpha (Lyt-2) is phosphorylated in vivo after phorbol 12-myristate 13-acetate (PMA) treatment of cells.	Tetradecanoylphorbol Acetate	173-204	CD8 antigen, alpha chain	Mus musculus	123-132
2115328-0	1990	Murine T-cell differentiation antigen CD8 is a direct substrate of protein kinase C. Murine T cell differentiation antigen CD8 alpha (Lyt-2) is phosphorylated in vivo after phorbol 12-myristate 13-acetate (PMA) treatment of cells.	Tetradecanoylphorbol Acetate	173-204	CD8 antigen, alpha chain	Mus musculus	134-139
2115328-0	1990	Murine T-cell differentiation antigen CD8 is a direct substrate of protein kinase C. Murine T cell differentiation antigen CD8 alpha (Lyt-2) is phosphorylated in vivo after phorbol 12-myristate 13-acetate (PMA) treatment of cells.	Tetradecanoylphorbol Acetate	206-209	CD8 antigen, alpha chain	Mus musculus	123-132
2176152-6	1990	We show also that RA represses the transcriptional activity of a reporter gene containing a TPA responding AP1 binding site driving the HSV tk promoter.	Tetradecanoylphorbol Acetate	92-95	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	107-110
1712842-6	1990	Administration of TPA (10(-8) mol (kg body weight)-1) in combination with CCK8 resulted in marked attenuation of the CCK8-evoked secretory response.	Tetradecanoylphorbol Acetate	18-21	Body weight QTL 17	Rattus norvegicus	43-52
1712842-8	1990	Simultaneous injection of polymyxin B (10(-8) mol (kg body weight)-1), an inhibitor of protein kinase C, with TPA and CCK8 reversed the inhibitory effect of the phorbol ester on CCK8-induced pancreatic juice flow, total protein output and amylase release.	Tetradecanoylphorbol Acetate	110-113	Body weight QTL 17	Rattus norvegicus	59-68
2115328-0	1990	Murine T-cell differentiation antigen CD8 is a direct substrate of protein kinase C. Murine T cell differentiation antigen CD8 alpha (Lyt-2) is phosphorylated in vivo after phorbol 12-myristate 13-acetate (PMA) treatment of cells.	Tetradecanoylphorbol Acetate	206-209	CD8 antigen, alpha chain	Mus musculus	134-139
2329998-7	1990	The effects of IL-1 were mimicked by the tumor promoter phorbol 12-myristate 13-acetate (PMA) at 1-100 nM, which inhibited CDP and reduced procollagen alpha 1(I) mRNA levels to a similar extent.	Tetradecanoylphorbol Acetate	89-92	interleukin 1 complex	Mus musculus	15-19
2265452-12	1990	In addition, e6MP inhibits TPA-induced monocytic/macrophage differentiation as characterized by stabilization of c-fms mRNA and cellular adherence.	Tetradecanoylphorbol Acetate	27-30	colony stimulating factor 1 receptor	Homo sapiens	113-118
2194589-2	1990	Human neutrophils express high levels of the DREG antigen, whose expression is downregulated after treatment with phorbol myristate acetate, or the chemotactic factors C5a and FMLP.	Tetradecanoylphorbol Acetate	114-139	adhesion G protein-coupled receptor G6	Homo sapiens	45-49
2174781-7	1990	KRDS and RGDS inhibited 4 beta-phorbol-12-myristate-13-acetate (PMA)-induced aggregation and fibrinogen binding, while proteins were normally phosphorylated.	Tetradecanoylphorbol Acetate	24-62	ral guanine nucleotide dissociation stimulator	Homo sapiens	9-13
2174781-7	1990	KRDS and RGDS inhibited 4 beta-phorbol-12-myristate-13-acetate (PMA)-induced aggregation and fibrinogen binding, while proteins were normally phosphorylated.	Tetradecanoylphorbol Acetate	64-67	ral guanine nucleotide dissociation stimulator	Homo sapiens	9-13
2293616-5	1990	Immunoreactive beta-endorphin secretion was found to be stimulated two- to fourfold in the control cells after incubation with corticotropin-releasing factor (10(-7) M), forskolin (10(-6) M), or TPA (10(-7) M) for 4 h. In cells rendered PKC deficient, TPA-stimulated immunoreactive beta-endorphin release was abolished, forskolin-stimulated release was unaffected, and corticotropin-releasing factor-stimulated release was depressed.	Tetradecanoylphorbol Acetate	195-198	pro-opiomelanocortin-alpha	Mus musculus	15-29
1973035-1	1990	We have found that an anti-CD11c monoclonal antibody (MAb) inhibits the respiratory burst induced in phorbol 12-myristate 13-acetate (PMA)-differentiated U937 cells as well as in human peripheral blood monocytes and neutrophils upon cell stimulation with concanavalin A.	Tetradecanoylphorbol Acetate	101-132	integrin subunit alpha X	Homo sapiens	27-32
1973035-1	1990	We have found that an anti-CD11c monoclonal antibody (MAb) inhibits the respiratory burst induced in phorbol 12-myristate 13-acetate (PMA)-differentiated U937 cells as well as in human peripheral blood monocytes and neutrophils upon cell stimulation with concanavalin A.	Tetradecanoylphorbol Acetate	134-137	integrin subunit alpha X	Homo sapiens	27-32
2293616-5	1990	Immunoreactive beta-endorphin secretion was found to be stimulated two- to fourfold in the control cells after incubation with corticotropin-releasing factor (10(-7) M), forskolin (10(-6) M), or TPA (10(-7) M) for 4 h. In cells rendered PKC deficient, TPA-stimulated immunoreactive beta-endorphin release was abolished, forskolin-stimulated release was unaffected, and corticotropin-releasing factor-stimulated release was depressed.	Tetradecanoylphorbol Acetate	252-255	pro-opiomelanocortin-alpha	Mus musculus	15-29
2242429-8	1990	In contrast, the fourth patient, a nonresponder to SAC or TPA/Ca2+, demonstrated increased DNA synthesis at day 3 when cocultured with IL-4 and IL-5.	Tetradecanoylphorbol Acetate	58-61	interleukin 5	Homo sapiens	144-148
2140592-3	1990	Northern blot analysis showed that the c-FMS mRNA levels in THP-1 cells was greatly enhanced during TPA-induced monocytic differentiation.	Tetradecanoylphorbol Acetate	100-103	colony stimulating factor 1 receptor	Homo sapiens	39-44
2161893-7	1990	Similar results were obtained with PMN after up regulation of CR1, CR3, Fc, and FMLPL receptors by incubation at 37 degrees C for 10 min with or without phorbol myristate acetate.	Tetradecanoylphorbol Acetate	153-178	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	62-65
24911002-6	2015	Moreover, both GSK1016790A (GSK) and phorbol myristate acetate and, two widely employed TRPV4 agonists, induced intracellular Ca(2+) signals uniquely in presence of extracellular Ca(2+).	Tetradecanoylphorbol Acetate	37-62	transient receptor potential cation channel subfamily V member 4	Homo sapiens	88-93
1692963-6	1990	The time courses of p42 tyrosine phosphorylation and PK42 activation were similar, reaching maximal levels within 10 min and returning to basal levels within 5 h. Both p42 tyrosine phosphorylation and PK42 activation were stimulated by low concentrations of phorbol esters, and the responses of p42 and PK42 to TPA were abolished by chronic 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	311-314	cyclin-dependent kinase 20	Mus musculus	168-171
1692963-6	1990	The time courses of p42 tyrosine phosphorylation and PK42 activation were similar, reaching maximal levels within 10 min and returning to basal levels within 5 h. Both p42 tyrosine phosphorylation and PK42 activation were stimulated by low concentrations of phorbol esters, and the responses of p42 and PK42 to TPA were abolished by chronic 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	341-377	cyclin-dependent kinase 20	Mus musculus	20-23
1692963-6	1990	The time courses of p42 tyrosine phosphorylation and PK42 activation were similar, reaching maximal levels within 10 min and returning to basal levels within 5 h. Both p42 tyrosine phosphorylation and PK42 activation were stimulated by low concentrations of phorbol esters, and the responses of p42 and PK42 to TPA were abolished by chronic 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	341-377	cyclin-dependent kinase 20	Mus musculus	168-171
1692963-6	1990	The time courses of p42 tyrosine phosphorylation and PK42 activation were similar, reaching maximal levels within 10 min and returning to basal levels within 5 h. Both p42 tyrosine phosphorylation and PK42 activation were stimulated by low concentrations of phorbol esters, and the responses of p42 and PK42 to TPA were abolished by chronic 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	341-377	cyclin-dependent kinase 20	Mus musculus	168-171
1692963-6	1990	The time courses of p42 tyrosine phosphorylation and PK42 activation were similar, reaching maximal levels within 10 min and returning to basal levels within 5 h. Both p42 tyrosine phosphorylation and PK42 activation were stimulated by low concentrations of phorbol esters, and the responses of p42 and PK42 to TPA were abolished by chronic 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	379-382	cyclin-dependent kinase 20	Mus musculus	20-23
1692963-6	1990	The time courses of p42 tyrosine phosphorylation and PK42 activation were similar, reaching maximal levels within 10 min and returning to basal levels within 5 h. Both p42 tyrosine phosphorylation and PK42 activation were stimulated by low concentrations of phorbol esters, and the responses of p42 and PK42 to TPA were abolished by chronic 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	379-382	cyclin-dependent kinase 20	Mus musculus	168-171
1692963-6	1990	The time courses of p42 tyrosine phosphorylation and PK42 activation were similar, reaching maximal levels within 10 min and returning to basal levels within 5 h. Both p42 tyrosine phosphorylation and PK42 activation were stimulated by low concentrations of phorbol esters, and the responses of p42 and PK42 to TPA were abolished by chronic 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	379-382	cyclin-dependent kinase 20	Mus musculus	168-171
2121373-1	1990	In this study, we investigated the biological effects of N-m-KRTLR using as an in vitro model the induction of the IL-2 receptor and IL-2 secretion by Jurkat cells in response to stimulation with 12-O tetradecanoylphorbol-13-acetate (TPA) plus phytohemagglutinin (PHA) and TPA plus OKT3 mAb.	Tetradecanoylphorbol Acetate	196-232	interleukin 2 receptor subunit beta	Homo sapiens	115-128
2121373-2	1990	N-m-KRTLR significantly suppressed induction of the IL-2 receptor on the surface of the Jurkat cells by TPA plus either PHA or OKT3 mAb.	Tetradecanoylphorbol Acetate	104-107	interleukin 2 receptor subunit beta	Homo sapiens	52-65
2170389-5	1990	Addition of the protein kinase C inhibitor staurosporine or down-regulation of protein kinase C by prolonged incubation with phorbol 12-myristate 13-acetate partially reduced the effects of angiotensin II and alpha-thrombin and completely blunted the phorbol 12-myristate 13-acetate-induced stimulation of Na+/K+/Cl- cotransport but did not affect EGF-induced stimulation.	Tetradecanoylphorbol Acetate	125-156	epidermal growth factor like 1	Rattus norvegicus	348-351
2211670-3	1990	Treatment of the cells with TPA stimulated the phosphorylation of serine residues in PLC-beta, but the phosphorylation state of PLC-gamma and PLC-delta was not changed significantly.	Tetradecanoylphorbol Acetate	28-31	phospholipase C, beta 1	Mus musculus	85-93
2283681-5	1990	Low concentrations of TPA (2 x 10(-10) M) had no effect on Ca2+ release due to EGF, TGR-alpha or bradykinin but resulted in a rapid return of [Ca2+]i to baseline levels for EGF or TGF-alpha.	Tetradecanoylphorbol Acetate	22-25	transforming growth factor alpha	Homo sapiens	180-189
1692963-7	1990	Chronic TPA treatment had less effect on serum-induced p42 tyrosine phosphorylation and PK42 activation.	Tetradecanoylphorbol Acetate	8-11	cyclin-dependent kinase 20	Mus musculus	55-58
11452037-8	2001	Furthermore, when human cells were exposed to the PKC activator phorbol 12-myristate 13-acetate, an increase in redox activity was observed that corresponded to an increase in the phosphorylation status of APE/Ref-1.	Tetradecanoylphorbol Acetate	64-95	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	206-209
2356754-0	1990	12-O-tetradecanoylphorbol-13-acetate, a phorbol ester stimulating protein kinase C, inhibits bone resorption in vitro induced by parathyroid hormone and parathyroid hormone-related peptide of malignancy.	Tetradecanoylphorbol Acetate	0-36	parathyroid hormone like hormone	Homo sapiens	153-188
2110452-8	1990	Phorbol 12-myristate 13-acetate (PMA) (0.1-10 microM) also stimulated mucin release strongly, implicating a responsive protein-kinase C-dependent pathway.	Tetradecanoylphorbol Acetate	0-31	LOC100508689	Homo sapiens	70-75
2110452-8	1990	Phorbol 12-myristate 13-acetate (PMA) (0.1-10 microM) also stimulated mucin release strongly, implicating a responsive protein-kinase C-dependent pathway.	Tetradecanoylphorbol Acetate	33-36	LOC100508689	Homo sapiens	70-75
2156582-8	1990	The degree of CD28 aggregation required for activation was investigated by preparing soluble 9.3 x 9.3 conjugates ranging in size from approximately 300 Kd to greater than 1,000 Kd, and comparing their function in T-cell proliferation assays with phorbol-12-myristate-13-acetate (PMA), anti-CD3, or IL-2.	Tetradecanoylphorbol Acetate	247-278	CD28 molecule	Homo sapiens	14-18
2156582-8	1990	The degree of CD28 aggregation required for activation was investigated by preparing soluble 9.3 x 9.3 conjugates ranging in size from approximately 300 Kd to greater than 1,000 Kd, and comparing their function in T-cell proliferation assays with phorbol-12-myristate-13-acetate (PMA), anti-CD3, or IL-2.	Tetradecanoylphorbol Acetate	280-283	CD28 molecule	Homo sapiens	14-18
2156582-10	1990	The inositol phospholipid (InsP) generation and increase in [Ca2+]i after CD28 receptor aggregation appeared to proceed through a pathway different from the CD3/T-cell receptor (TCR) pathway since it was enhanced by pretreatment with PMA, while the InsP and [Ca2+]i signal from crosslinking CD3 was suppressed by PMA.	Tetradecanoylphorbol Acetate	234-237	CD28 molecule	Homo sapiens	74-78
2138707-1	1990	Proto-oncogene products c-Fos and c-Jun form a complex which binds with high affinity to the 12-O-tetradecanoylphorbol-13-acetate (TPA) response DNA element and which stimulates transcription of phorbol ester- inducible genes.	Tetradecanoylphorbol Acetate	93-129	jun proto-oncogene	Mus musculus	34-39
2138707-1	1990	Proto-oncogene products c-Fos and c-Jun form a complex which binds with high affinity to the 12-O-tetradecanoylphorbol-13-acetate (TPA) response DNA element and which stimulates transcription of phorbol ester- inducible genes.	Tetradecanoylphorbol Acetate	131-134	jun proto-oncogene	Mus musculus	34-39
2138707-8	1990	mXBP-c-Jun complexes can coexist with c-Fos-c-Jun complexes and can bind with high affinity to CRE, but not to TPA response DNA element, sequences.	Tetradecanoylphorbol Acetate	111-114	jun proto-oncogene	Mus musculus	5-10
2157204-2	1990	Desensitization of protein kinase C (PKC) by pretreatment with phorbol ester [phorbol 12-tetradecanoate 13-acetate (TPA)] for 8 hr abolished the secretion induced by TPA as well as the enhancement of TPA-induced beta-endorphin release produced by IL-1.	Tetradecanoylphorbol Acetate	78-114	pro-opiomelanocortin-alpha	Mus musculus	212-226
2157204-2	1990	Desensitization of protein kinase C (PKC) by pretreatment with phorbol ester [phorbol 12-tetradecanoate 13-acetate (TPA)] for 8 hr abolished the secretion induced by TPA as well as the enhancement of TPA-induced beta-endorphin release produced by IL-1.	Tetradecanoylphorbol Acetate	78-114	interleukin 1 complex	Mus musculus	247-251
2157204-2	1990	Desensitization of protein kinase C (PKC) by pretreatment with phorbol ester [phorbol 12-tetradecanoate 13-acetate (TPA)] for 8 hr abolished the secretion induced by TPA as well as the enhancement of TPA-induced beta-endorphin release produced by IL-1.	Tetradecanoylphorbol Acetate	116-119	pro-opiomelanocortin-alpha	Mus musculus	212-226
2157204-2	1990	Desensitization of protein kinase C (PKC) by pretreatment with phorbol ester [phorbol 12-tetradecanoate 13-acetate (TPA)] for 8 hr abolished the secretion induced by TPA as well as the enhancement of TPA-induced beta-endorphin release produced by IL-1.	Tetradecanoylphorbol Acetate	116-119	interleukin 1 complex	Mus musculus	247-251
2157204-2	1990	Desensitization of protein kinase C (PKC) by pretreatment with phorbol ester [phorbol 12-tetradecanoate 13-acetate (TPA)] for 8 hr abolished the secretion induced by TPA as well as the enhancement of TPA-induced beta-endorphin release produced by IL-1.	Tetradecanoylphorbol Acetate	166-169	pro-opiomelanocortin-alpha	Mus musculus	212-226
2157204-2	1990	Desensitization of protein kinase C (PKC) by pretreatment with phorbol ester [phorbol 12-tetradecanoate 13-acetate (TPA)] for 8 hr abolished the secretion induced by TPA as well as the enhancement of TPA-induced beta-endorphin release produced by IL-1.	Tetradecanoylphorbol Acetate	166-169	interleukin 1 complex	Mus musculus	247-251
2157204-2	1990	Desensitization of protein kinase C (PKC) by pretreatment with phorbol ester [phorbol 12-tetradecanoate 13-acetate (TPA)] for 8 hr abolished the secretion induced by TPA as well as the enhancement of TPA-induced beta-endorphin release produced by IL-1.	Tetradecanoylphorbol Acetate	166-169	pro-opiomelanocortin-alpha	Mus musculus	212-226
2157204-2	1990	Desensitization of protein kinase C (PKC) by pretreatment with phorbol ester [phorbol 12-tetradecanoate 13-acetate (TPA)] for 8 hr abolished the secretion induced by TPA as well as the enhancement of TPA-induced beta-endorphin release produced by IL-1.	Tetradecanoylphorbol Acetate	166-169	interleukin 1 complex	Mus musculus	247-251
2155264-9	1990	Despite the ability of PMA to induce high density CD28 expression in CD3- cells, CD3- thymocytes did not proliferate in response to PMA plus anti-CD28 mAb, in contrast to unseparated cells.	Tetradecanoylphorbol Acetate	23-26	CD28 molecule	Homo sapiens	50-54
2137493-6	1990	Treatment of mononuclear cells with PMA profoundly inhibited the increase in [Ca2+]i induced by L10.	Tetradecanoylphorbol Acetate	36-39	ribosomal protein L10	Homo sapiens	96-99
2105318-2	1990	Activators of PKC such as phorbol 12-myristate 13-acetate (PMA) or 1-oleoyl 2-acetyl glycerol mimicked the stimulatory effect of NGF and bFGF on SCG10 mRNA levels.	Tetradecanoylphorbol Acetate	26-57	nerve growth factor	Rattus norvegicus	129-132
2105318-2	1990	Activators of PKC such as phorbol 12-myristate 13-acetate (PMA) or 1-oleoyl 2-acetyl glycerol mimicked the stimulatory effect of NGF and bFGF on SCG10 mRNA levels.	Tetradecanoylphorbol Acetate	26-57	fibroblast growth factor 2	Rattus norvegicus	137-141
2105318-2	1990	Activators of PKC such as phorbol 12-myristate 13-acetate (PMA) or 1-oleoyl 2-acetyl glycerol mimicked the stimulatory effect of NGF and bFGF on SCG10 mRNA levels.	Tetradecanoylphorbol Acetate	59-62	nerve growth factor	Rattus norvegicus	129-132
2105318-2	1990	Activators of PKC such as phorbol 12-myristate 13-acetate (PMA) or 1-oleoyl 2-acetyl glycerol mimicked the stimulatory effect of NGF and bFGF on SCG10 mRNA levels.	Tetradecanoylphorbol Acetate	59-62	fibroblast growth factor 2	Rattus norvegicus	137-141
1970448-4	1990	By contrast, one of the panmyeloid antigens, CD13 (MCS-2) antigen was induced on leukemic cells corresponding to early thymocytes in 5 out of 7 cases in TPA-added culture and in 3 cases even in TPA-free culture.	Tetradecanoylphorbol Acetate	153-156	alanyl aminopeptidase, membrane	Homo sapiens	45-49
1970448-4	1990	By contrast, one of the panmyeloid antigens, CD13 (MCS-2) antigen was induced on leukemic cells corresponding to early thymocytes in 5 out of 7 cases in TPA-added culture and in 3 cases even in TPA-free culture.	Tetradecanoylphorbol Acetate	194-197	alanyl aminopeptidase, membrane	Homo sapiens	45-49
2152769-12	1990	12-O-Tetradecanoyl-phorbol-13-acetate also reduced the binding of 125I-TGF-alpha, but not 125I-IGF-I, to PC cells.	Tetradecanoylphorbol Acetate	0-37	transforming growth factor alpha	Homo sapiens	71-80
2272247-1	1990	Using flow cytometry in combination with membrane permeabilization techniques to enhance binding of antibodies with immunoreactive protein within the cytoplasm, we have developed a method to examine the ornithine decarboxylase (ODC) activity present within subpopulations of epidermal cells following acute and chronic exposure to the phorbol ester tumor promoter 12-0-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	402-405	ornithine decarboxylase 1	Homo sapiens	228-231
2272247-2	1990	The method described has the sensitivity to detect basal levels of ODC as well as increases in ODC at early time points following treatment with TPA and has the additional advantage of allowing subpopulation identification and characterization.	Tetradecanoylphorbol Acetate	145-148	ornithine decarboxylase 1	Homo sapiens	95-98
2105228-5	1990	Addition of interleukin 2 (IL-2) to cultures of lymphocytes and UV-irradiated DC restored responsiveness to PMA, suggesting that a decrease in cytokine production was the central event in UV-induced accessory cell inhibition.	Tetradecanoylphorbol Acetate	108-111	interleukin 2	Canis lupus familiaris	12-25
2105228-5	1990	Addition of interleukin 2 (IL-2) to cultures of lymphocytes and UV-irradiated DC restored responsiveness to PMA, suggesting that a decrease in cytokine production was the central event in UV-induced accessory cell inhibition.	Tetradecanoylphorbol Acetate	108-111	interleukin 2	Canis lupus familiaris	27-31
2105228-6	1990	Cyclosporine, known to interfere with IL-2 release and responses, completely blocked both ConA- and PMA-induced lymphocyte proliferation but did not interfere with ConA-triggered cluster formation.	Tetradecanoylphorbol Acetate	100-103	interleukin 2	Canis lupus familiaris	38-42
2178218-3	1990	PMA further augmented the elevation in cAMP accumulation induced by cholera toxin, forskolin, and hCG.	Tetradecanoylphorbol Acetate	0-3	chorionic gonadotropin subunit beta 5	Homo sapiens	98-101
2178218-5	1990	PMA inhibited the increase in 3 beta HSD mRNA levels induced by hCG in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-3	chorionic gonadotropin subunit beta 5	Homo sapiens	64-67
2144778-4	1990	The results also demonstrate that dexamethasone inhibits the appearance of c-fms transcripts associated with TPA treatment.	Tetradecanoylphorbol Acetate	109-112	colony stimulating factor 1 receptor	Homo sapiens	75-80
2144778-6	1990	These findings indicated that TPA increases c-fms expression by a dexamethasone-sensitive posttranscriptional mechanism.	Tetradecanoylphorbol Acetate	30-33	colony stimulating factor 1 receptor	Homo sapiens	44-49
2144778-9	1990	These findings suggested that TPA may regulate certain features of monocytic differentiation, such as c-fms gene expression, through the formation of arachidonic acid metabolites.	Tetradecanoylphorbol Acetate	30-33	colony stimulating factor 1 receptor	Homo sapiens	102-107
2144778-11	1990	However, the cyclooxygenase metabolite, prostaglandin E2, inhibited the TPA-induced increases in c-fms mRNA levels.	Tetradecanoylphorbol Acetate	72-75	colony stimulating factor 1 receptor	Homo sapiens	97-102
2144778-12	1990	Taken together, the results indicate that TPA regulates c-fms gene expression by a dexamethasone-sensitive mechanism and that c-fms mRNA levels are controlled by metabolites of the arachidonic acid pathway.	Tetradecanoylphorbol Acetate	42-45	colony stimulating factor 1 receptor	Homo sapiens	56-61
2168414-4	1990	Furthermore, when thrombin (0.1 unit/ml) or the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) had raised pHi from 7.13 +/- 0.05 to 7.35 +/- 0.07 (n = 30), addition of NaF (2.5-10 mM) rapidly restored pHi to values found before stimulation.	Tetradecanoylphorbol Acetate	100-103	glucose-6-phosphate isomerase	Homo sapiens	116-119
2168414-4	1990	Furthermore, when thrombin (0.1 unit/ml) or the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) had raised pHi from 7.13 +/- 0.05 to 7.35 +/- 0.07 (n = 30), addition of NaF (2.5-10 mM) rapidly restored pHi to values found before stimulation.	Tetradecanoylphorbol Acetate	100-103	glucose-6-phosphate isomerase	Homo sapiens	211-214
2117926-6	1990	The HDC activity increased 1.8-fold when the cells were stimulated by phorbol myristate acetate, which is known to activate protein kinase C, and this increase was blocked by staurosporine, a potent inhibitor of protein kinase C.	Tetradecanoylphorbol Acetate	70-95	histidine decarboxylase	Homo sapiens	4-7
2204504-1	1990	The novel early activation antigen, EA1, has been shown to be induced by mitogens, antigens and the tumour promoter, phorbol myristate acetate (PMA), on human lymphocytes.	Tetradecanoylphorbol Acetate	117-142	CD69 molecule	Homo sapiens	36-39
2204504-1	1990	The novel early activation antigen, EA1, has been shown to be induced by mitogens, antigens and the tumour promoter, phorbol myristate acetate (PMA), on human lymphocytes.	Tetradecanoylphorbol Acetate	144-147	CD69 molecule	Homo sapiens	36-39
2231411-8	1990	Furthermore, melittin-stimulated renin secretion is not produced by inhibition of protein kinase C, since an activator of protein kinase C (12-O-tetradecanoylphorbol 13-acetate, TPA), enhanced rather than antagonized melittin-stimulated renin secretion.	Tetradecanoylphorbol Acetate	178-181	renin	Rattus norvegicus	33-38
2135379-4	1990	In monocyte-derived macrophages, both IFN-alpha and IFN-beta stimulated the phorbol myristate acetate (PMA) induced OB response in the patient group as well as in the blood donor control group.	Tetradecanoylphorbol Acetate	76-101	interferon beta 1	Homo sapiens	52-60
2135379-4	1990	In monocyte-derived macrophages, both IFN-alpha and IFN-beta stimulated the phorbol myristate acetate (PMA) induced OB response in the patient group as well as in the blood donor control group.	Tetradecanoylphorbol Acetate	103-106	interferon beta 1	Homo sapiens	52-60
2163613-9	1990	Furthermore, the effects of insulin and PMA on glucose consumption, lactate production, Fru-2,6-P2 levels and PFK2 activity are additive, and the effect of insulin on Fru-2,6-P2 production is not altered by pre-treatment of the cells with the phorbol ester.	Tetradecanoylphorbol Acetate	40-43	zinc finger and BTB domain containing 22	Homo sapiens	88-91
1692959-3	1990	Although IL-1 induction of the IL-2 promoter in these cells required costimulus with phorbol myristate acetate, the signal induced by IL-1 was qualitatively different.	Tetradecanoylphorbol Acetate	85-110	interleukin 1 complex	Mus musculus	9-13
1692963-6	1990	The time courses of p42 tyrosine phosphorylation and PK42 activation were similar, reaching maximal levels within 10 min and returning to basal levels within 5 h. Both p42 tyrosine phosphorylation and PK42 activation were stimulated by low concentrations of phorbol esters, and the responses of p42 and PK42 to TPA were abolished by chronic 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	311-314	cyclin-dependent kinase 20	Mus musculus	20-23
1692963-6	1990	The time courses of p42 tyrosine phosphorylation and PK42 activation were similar, reaching maximal levels within 10 min and returning to basal levels within 5 h. Both p42 tyrosine phosphorylation and PK42 activation were stimulated by low concentrations of phorbol esters, and the responses of p42 and PK42 to TPA were abolished by chronic 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	311-314	cyclin-dependent kinase 20	Mus musculus	168-171
2141686-6	1990	It was further demonstrated that the M-CSF (or CSF-1) and c-fms antisense oligomers acted synergistically on inhibition of macrophage formation induced by PMA and hrGM-CSF, but had no inhibitory effect on the macrophage formation induced by 1-alpha-25-(OH)2D3.	Tetradecanoylphorbol Acetate	155-158	colony stimulating factor 1 receptor	Homo sapiens	58-63
1970571-6	1990	The basal phosphorylation of P150 observed in 32P-labeled cells was increased 2-fold by phorbol ester (PMA) treatment and reduced 30% by treatment with the isoquinolinsulfonamide H-7.	Tetradecanoylphorbol Acetate	103-106	chromatin assembly factor 1 subunit A	Homo sapiens	29-33
1970571-7	1990	Phosphopeptide maps of partially digested P150, phosphorylated either in vitro with PKC or in intact 32P-labeled control or PMA-stimulated cells, were indistinguishable from one another.	Tetradecanoylphorbol Acetate	124-127	chromatin assembly factor 1 subunit A	Homo sapiens	42-46
1695590-12	1990	These results strongly suggest that the sequence element around the demethylated M1 site is involved in a multi-level control mechanism mediating the selective expression of the K13 gene in internal squamous epithelia and in DMBA/TPA-induced epidermal tumors.	Tetradecanoylphorbol Acetate	230-233	keratin 13	Mus musculus	178-181
2180965-10	1990	H-8, which suppressed ODC induction by forskolin and phorbol myristate acetate, enhanced both N-ras-induced ODC activity and neurite outgrowth.	Tetradecanoylphorbol Acetate	53-78	ornithine decarboxylase 1	Homo sapiens	22-25
2161931-4	1990	Unexpectedly, NGF and phorbol 12-myristate 13-acetate (PMA; 10-1,000 nM) synergistically stimulated the formation of short processes that were apparent within 30 min of NGF addition in 85% of these mutant cells.	Tetradecanoylphorbol Acetate	22-53	nerve growth factor	Rattus norvegicus	169-172
2161931-4	1990	Unexpectedly, NGF and phorbol 12-myristate 13-acetate (PMA; 10-1,000 nM) synergistically stimulated the formation of short processes that were apparent within 30 min of NGF addition in 85% of these mutant cells.	Tetradecanoylphorbol Acetate	55-58	nerve growth factor	Rattus norvegicus	169-172
2200903-2	1990	Treatment of these cells with phorbol 12-O-tetradecanoate 13-acetate (TPA), insulin and concanavalin A (Con A) resulted in transient accumulation of c-myc transcripts within 2 hours.	Tetradecanoylphorbol Acetate	70-73	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	149-154
2316641-6	1990	TPA (a tumor-promoting phorbol ester) and OAG (synthetic diacylglycerol), both potent activators of protein kinase C, imitate the action of EGF in rapidly elevating pHi and stimulating cell growth in thyroid cells.	Tetradecanoylphorbol Acetate	0-3	glucose-6-phosphate isomerase	Homo sapiens	165-168
1974593-3	1990	The ability of the phorbol ester, phorbol 12-myristate 13-acetate (PMA), and the calcium ionophore, A23187, in co-stimulation with PHA, to enhance the IL-2 secretion, IL-2R expression and 3H thymidine incorporation were studied in the PBMC of colorectal cancer patients.	Tetradecanoylphorbol Acetate	34-65	interleukin 2 receptor subunit alpha	Homo sapiens	167-172
1974593-7	1990	A23187 is known to be effective in elevating cytosolic free Ca2+ and PMA is regarded as an activator of protein kinase C. Therefore, we may conclude that the impairment of IL-2 production and IL-2R expression in PHA-stimulated cultures is mainly due to failure of the free Ca2+ release which can be repaired by A23187.	Tetradecanoylphorbol Acetate	69-72	interleukin 2 receptor subunit alpha	Homo sapiens	192-197
2160601-7	1990	beta-Actin gene transcription also was elevated synergistically by forskolin and PMA.	Tetradecanoylphorbol Acetate	81-84	actin, beta	Rattus norvegicus	0-10
2155021-9	1990	In both RES and ELI MOs, stimulation with TPA resulted in a biphasic pHi response: an initial acidification followed by a sustained alkalinization to a new steady-state pHi.	Tetradecanoylphorbol Acetate	42-45	glucose-6-phosphate isomerase	Homo sapiens	69-72
2155021-9	1990	In both RES and ELI MOs, stimulation with TPA resulted in a biphasic pHi response: an initial acidification followed by a sustained alkalinization to a new steady-state pHi.	Tetradecanoylphorbol Acetate	42-45	glucose-6-phosphate isomerase	Homo sapiens	169-172
2155021-11	1990	The new steady-state pHi attained after TPA stimulation was equivalent in RES and ELI MOs (7.28 +/- 0.04 and 7.31 +/- 0.06, respectively), indicating comparable stimulated Na+/H+ antiport activity.	Tetradecanoylphorbol Acetate	40-43	glucose-6-phosphate isomerase	Homo sapiens	21-24
2155021-14	1990	This suggested that the TPA-induced pHi reduction was due in part to acid produced via the respiratory burst, and in part to other acid-generating pathways stimulated by TPA.	Tetradecanoylphorbol Acetate	24-27	glucose-6-phosphate isomerase	Homo sapiens	36-39
2155021-14	1990	This suggested that the TPA-induced pHi reduction was due in part to acid produced via the respiratory burst, and in part to other acid-generating pathways stimulated by TPA.	Tetradecanoylphorbol Acetate	170-173	glucose-6-phosphate isomerase	Homo sapiens	36-39
2323487-4	1990	Chronic exposure of GH3 cells to TPA, which strongly down-regulates protein kinase C activity, completely inhibited acute TPA stimulation of transient expression of a transfected PRL promoter construct ((-187)PRL-CAT), but did not inhibit EGF stimulation of either accumulation of endogenous PRL mRNA or of expression of (-187)PRL-CAT.	Tetradecanoylphorbol Acetate	33-36	epidermal growth factor like 1	Rattus norvegicus	239-242
2150599-5	1990	In the c-jun promoter the 12-0-tetradecanoyl-phorbol-13-acetate (TPA) response element (TRE) mediates this effect.	Tetradecanoylphorbol Acetate	65-68	jun proto-oncogene	Mus musculus	7-12
2153927-1	1990	We have delineated a positive regulatory element in the interleukin-2 receptor alpha-chain gene (IL-2R alpha) between positions -299 and -243 that can potently activate a heterologous (herpesvirus thymidine kinase [tk]) promoter in phorbol myristate acetate (PMA)-induced Jurkat T cells and is functional when cloned in either orientation.	Tetradecanoylphorbol Acetate	232-257	interleukin 2 receptor subunit alpha	Homo sapiens	97-108
2153927-1	1990	We have delineated a positive regulatory element in the interleukin-2 receptor alpha-chain gene (IL-2R alpha) between positions -299 and -243 that can potently activate a heterologous (herpesvirus thymidine kinase [tk]) promoter in phorbol myristate acetate (PMA)-induced Jurkat T cells and is functional when cloned in either orientation.	Tetradecanoylphorbol Acetate	259-262	interleukin 2 receptor subunit alpha	Homo sapiens	97-108
11452037-8	2001	Furthermore, when human cells were exposed to the PKC activator phorbol 12-myristate 13-acetate, an increase in redox activity was observed that corresponded to an increase in the phosphorylation status of APE/Ref-1.	Tetradecanoylphorbol Acetate	64-95	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	210-215
7818761-1	1995	This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain.	Tetradecanoylphorbol Acetate	102-138	jun proto-oncogene	Mus musculus	173-178
1688581-7	1990	The level of PI-PLC-sensitive HUVEC DAF was increased three- to fourfold by overnight treatment of cultures with the protein kinase C activators, PMA (1 to 10 nM), phorbol-12,13-dibutyrate (10 to 100 nM), and teleocidin A (1 to 10 nM) under conditions where cell number, protein, and lactate dehydrogenase remain unchanged.	Tetradecanoylphorbol Acetate	146-149	phospholipase C beta 1	Homo sapiens	13-19
7818761-1	1995	This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain.	Tetradecanoylphorbol Acetate	140-143	jun proto-oncogene	Mus musculus	173-178
2151634-1	1990	The expression of the low-affinity receptor for IgE Fc epsilon RII) in the human monocyte-like U-937 cell line can be upregulated by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and by IgE.	Tetradecanoylphorbol Acetate	151-187	Fc epsilon receptor II	Homo sapiens	52-66
34962379-3	2022	In this article, we have constructed a metal-free porous polyketone (TPA-DPA PPK) with donor-acceptor (D-A) groups with an extensive pi-conjugation by facile Friedel-Crafts acylation reaction between triphenylamine (TPA) and pyridine-2,6-dicarbonyl dichloride (DPA).	Tetradecanoylphorbol Acetate	69-72	kallikrein B1	Homo sapiens	77-80
2151634-1	1990	The expression of the low-affinity receptor for IgE Fc epsilon RII) in the human monocyte-like U-937 cell line can be upregulated by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and by IgE.	Tetradecanoylphorbol Acetate	189-192	Fc epsilon receptor II	Homo sapiens	52-66
2151634-2	1990	TPA induces terminal differentiation of U-937 cells and causes a four- to fivefold increase in the number of Fc epsilon RII.	Tetradecanoylphorbol Acetate	0-3	Fc epsilon receptor II	Homo sapiens	109-123
2151634-4	1990	IgE alone has a modest effect on the expression of Fc epsilon RII (about a 10% increase), while simultaneous treatment of U-937 cells with TPA and IgE has a cooperative effect, causing an eightfold increase in the number of Fc epsilon RII.	Tetradecanoylphorbol Acetate	139-142	Fc epsilon receptor II	Homo sapiens	51-65
2151634-4	1990	IgE alone has a modest effect on the expression of Fc epsilon RII (about a 10% increase), while simultaneous treatment of U-937 cells with TPA and IgE has a cooperative effect, causing an eightfold increase in the number of Fc epsilon RII.	Tetradecanoylphorbol Acetate	139-142	Fc epsilon receptor II	Homo sapiens	224-238
2151634-5	1990	Cycloheximide strongly suppresses the expression of Fc epsilon RII, both in TPA-stimulated and unstimulated cells; this effect can be partly reversed by culturing the cells in the presence of IgE.	Tetradecanoylphorbol Acetate	76-79	Fc epsilon receptor II	Homo sapiens	52-66
34962379-3	2022	In this article, we have constructed a metal-free porous polyketone (TPA-DPA PPK) with donor-acceptor (D-A) groups with an extensive pi-conjugation by facile Friedel-Crafts acylation reaction between triphenylamine (TPA) and pyridine-2,6-dicarbonyl dichloride (DPA).	Tetradecanoylphorbol Acetate	216-219	kallikrein B1	Homo sapiens	77-80
2196473-6	1990	Major induced alterations included down-regulation of CD4 (induced by TPA, and to a lesser extent by IFN-alpha), TPA-induced decrease of cell surface expression of transferrin receptor (unmodified by IFN-alpha) and IFN-alpha induced increase of antigen density (fluorescence intensity) of MHC class I antigen.	Tetradecanoylphorbol Acetate	113-116	MHC class I antigen	Homo sapiens	289-308
34962379-4	2022	TPA-DPA PPK is a metal-free catalyst for visible-light-driven CO2 photoreduction to CH4, which can be used as a solar fuel in the absence of any cocatalyst and sacrificial agent.	Tetradecanoylphorbol Acetate	0-3	kallikrein B1	Homo sapiens	8-11
34650643-12	2021	In a 12-O-tetradecanoylphorbol-13-acetate-induced mouse model, Tat-Trx1 reduced inflammatory damage by inhibiting inflammatory mediator and cytokine production.	Tetradecanoylphorbol Acetate	5-41	tyrosine aminotransferase	Mus musculus	63-66
33819446-12	2021	CD107a expression after induction by PMA and ionomycin did not correlate with other cytotoxicity measures.	Tetradecanoylphorbol Acetate	37-40	lysosomal associated membrane protein 1	Homo sapiens	0-6
2307488-4	1990	In contrast, macrophages from ACM-injected mice only increased their IL-1 production after the first 24-h incubation with PMA, and not after the second 24-h incubation.	Tetradecanoylphorbol Acetate	122-125	interleukin 1 complex	Mus musculus	69-73
34608498-8	2021	Furthermore, downregulation of matriptase suppressed TPA-induced MMP-9 expression and invasiveness via PAR-2/PLCgamma2/PKC/MAPK activation.	Tetradecanoylphorbol Acetate	53-56	F2R like trypsin receptor 1	Homo sapiens	103-108
2210911-5	1990	Northern blot hybridization with a human IL-2R and an IL-2 cDNA showed that bryostatin 1 (bryo 1), like the phorbol ester, PMA, activates the IL-2R gene.	Tetradecanoylphorbol Acetate	123-126	interleukin 2 receptor subunit alpha	Homo sapiens	142-147
28915606-10	2017	Matriptase silencing in the Her2, matriptase, and HAI-1 triple-positive SKBR3 human breast cancer cells enhanced Her2 protein down-regulation induced by a sustained exposure to phorbol 12-myristate 13-acetate (PMA), which down-regulated matriptase protein.	Tetradecanoylphorbol Acetate	177-208	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	50-55
28915606-10	2017	Matriptase silencing in the Her2, matriptase, and HAI-1 triple-positive SKBR3 human breast cancer cells enhanced Her2 protein down-regulation induced by a sustained exposure to phorbol 12-myristate 13-acetate (PMA), which down-regulated matriptase protein.	Tetradecanoylphorbol Acetate	210-213	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	50-55
34608498-8	2021	Furthermore, downregulation of matriptase suppressed TPA-induced MMP-9 expression and invasiveness via PAR-2/PLCgamma2/PKC/MAPK activation.	Tetradecanoylphorbol Acetate	53-56	phospholipase C gamma 2	Homo sapiens	109-118
1703134-3	1990	The anti-MA1 serum recognized gp350/220 in Western blotting to SDS-electrophoresed proteins from 12-O-tetradecanoylphorbol-13-acetate- and n-butyrate-treated B95-8 cells, but anti-MA2 and MA3 sera did not.	Tetradecanoylphorbol Acetate	97-133	PNMA family member 1	Homo sapiens	9-12
34724217-3	2022	Interestingly, 50 mmHg mechanical stressing induced the nuclear localization of NFAT1; but conversely decreased C-Jun and inhibited the expression of CD69 in lymphocytes under lipopolysaccharide or phorbol 12-myristate 13-acetate/ionomycin stimulation.	Tetradecanoylphorbol Acetate	198-229	jun proto-oncogene	Mus musculus	112-117
1688572-3	1990	FK-506 or CsA also inhibited proliferation, IL-2 production, and IL-2R expression in splenic T cells activated with ionomycin + PMA.	Tetradecanoylphorbol Acetate	128-131	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	10-13
22760862-3	2013	The topical treatment of GOH, 30 min prior to TPA (2 microg per 200 microl of acetone) treatment significantly inhibited TPA-induced skin edema, hyperplasia, COX-2 induction and oxidative stress response.	Tetradecanoylphorbol Acetate	121-124	cytochrome c oxidase II, mitochondrial	Mus musculus	158-163
21454541-4	2011	Interestingly, silencing p23 from LNCaP prostate cancer cells using RNAi markedly enhanced PKCdelta-dependent apoptosis and activation of PKCdelta downstream effectors ROCK and JNK by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	184-215	protein kinase C delta	Homo sapiens	138-146
21454541-5	2011	Moreover, translocation of PKCdelta to the plasma membrane by phorbol 12-myristate 13-acetate was enhanced in p23-depleted LNCaP cells.	Tetradecanoylphorbol Acetate	62-93	protein kinase C delta	Homo sapiens	27-35
32140039-4	2020	In the present study, we investigated the effect of eupatilin on phorbol 12-myristate 13-acetate (PMA)-induced MUC5AC and MUC5B expression in human airway epithelial cells.	Tetradecanoylphorbol Acetate	98-101	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	122-127
34724217-3	2022	Interestingly, 50 mmHg mechanical stressing induced the nuclear localization of NFAT1; but conversely decreased C-Jun and inhibited the expression of CD69 in lymphocytes under lipopolysaccharide or phorbol 12-myristate 13-acetate/ionomycin stimulation.	Tetradecanoylphorbol Acetate	198-229	CD69 antigen	Mus musculus	150-154
34437989-11	2021	These data suggest that PMA treatment induces IL1beta and TNF-alpha release and modulation of TNFRI/TNFRII expression promoting RGCs survival after axotomy.	Tetradecanoylphorbol Acetate	24-27	TNF receptor superfamily member 1B	Rattus norvegicus	100-106
34645720-5	2022	ANXA1 and A5 mRNA levels were significantly increased by protein kinase C (PKC) activator (12-O-Tetradecanoylphorbol-13-acetate; TPA), but not by dibutyryl cAMP.	Tetradecanoylphorbol Acetate	91-127	annexin A1	Mus musculus	0-5
14980082-4	2004	We previously showed that treatment of polarized TBA B4-3 cells with the strong protein kinase C (PKC) agonist phorbol 12-myristate-13-acetate (PMA) induced 3-4 days later a transient IFN-gamma mRNA expression and apical IFN-gamma protein secretion.	Tetradecanoylphorbol Acetate	111-142	interferon gamma	Sus scrofa	184-193
14980082-4	2004	We previously showed that treatment of polarized TBA B4-3 cells with the strong protein kinase C (PKC) agonist phorbol 12-myristate-13-acetate (PMA) induced 3-4 days later a transient IFN-gamma mRNA expression and apical IFN-gamma protein secretion.	Tetradecanoylphorbol Acetate	111-142	interferon gamma	Sus scrofa	221-230
14980082-4	2004	We previously showed that treatment of polarized TBA B4-3 cells with the strong protein kinase C (PKC) agonist phorbol 12-myristate-13-acetate (PMA) induced 3-4 days later a transient IFN-gamma mRNA expression and apical IFN-gamma protein secretion.	Tetradecanoylphorbol Acetate	144-147	interferon gamma	Sus scrofa	184-193
14980082-4	2004	We previously showed that treatment of polarized TBA B4-3 cells with the strong protein kinase C (PKC) agonist phorbol 12-myristate-13-acetate (PMA) induced 3-4 days later a transient IFN-gamma mRNA expression and apical IFN-gamma protein secretion.	Tetradecanoylphorbol Acetate	144-147	interferon gamma	Sus scrofa	221-230
14980082-5	2004	In the present paper, we report that after PMA removal, a transient phase of p44/p42 mitogen-activated protein (MAP) kinase activation occurs, followed by a strong downregulation preceding the phase of IFN-gamma expression.	Tetradecanoylphorbol Acetate	43-46	interferon gamma	Sus scrofa	202-211
11801661-5	2002	Although the myeloid cell lines as well as CD14+ cells express MMP-19 without stimulation, its production can be up-regulated by phorbol esters (PMA) or by adhesion.	Tetradecanoylphorbol Acetate	145-148	CD14 molecule	Homo sapiens	43-47
8622862-4	1996	Our data also show that OPN gene expression can be induced by treatment of SR-/- cells with epidermal growth factor (EGF) and 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	126-163	secreted phosphoprotein 1	Mus musculus	24-27
8622862-4	1996	Our data also show that OPN gene expression can be induced by treatment of SR-/- cells with epidermal growth factor (EGF) and 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	165-168	secreted phosphoprotein 1	Mus musculus	24-27
34645720-5	2022	ANXA1 and A5 mRNA levels were significantly increased by protein kinase C (PKC) activator (12-O-Tetradecanoylphorbol-13-acetate; TPA), but not by dibutyryl cAMP.	Tetradecanoylphorbol Acetate	129-132	annexin A1	Mus musculus	0-5
7527355-5	1994	Both cantharidin- and TPA-treated epidermis displayed altered distributions of K1 and K10 with expression only in the outermost cell layers, but the start of their postreplicative expression paralleled that in normal epidermis (18 h for K1 and 24 h for K10 after the last round of DNA synthesis).	Tetradecanoylphorbol Acetate	22-25	endothelin receptor type B modifier 1	Mus musculus	86-89
34645720-7	2022	TPA increased ANXA1 and A5 mRNA expression in a dose-dependent manner (1 nM to 10 muM), while the extent of the increase was much greater in ANXA1.	Tetradecanoylphorbol Acetate	0-3	annexin A1	Mus musculus	14-19
34547515-6	2021	Our study showed that isolation of T cells with the EasySep procedure, followed by activation with PMA/ionomycin, mimicked the psoriatic characteristics in an optimal manner with the production of inflammatory cytokines important in the pathogenesis of psoriasis, as well as increased expression of Ki67, S100A7, elafin and involucrin.	Tetradecanoylphorbol Acetate	99-102	peptidase inhibitor 3	Homo sapiens	313-319
34645720-7	2022	TPA increased ANXA1 and A5 mRNA expression in a dose-dependent manner (1 nM to 10 muM), while the extent of the increase was much greater in ANXA1.	Tetradecanoylphorbol Acetate	0-3	annexin A1	Mus musculus	141-146
34592416-5	2021	The PMA-treated S1P2knockout THP-1 Mphis showed decreases in IL-4/IL-13-induced phosphorylation of Janus-activated kinase (JAK) 1, JAK2, and STAT6 as well as mRNA expression of the M2 marker ARG1 compared with wild-type THP-1 Mphis.	Tetradecanoylphorbol Acetate	4-7	Janus kinase 2	Homo sapiens	131-135
34645720-8	2022	After stimulation with 10 nM or 1 muM TPA, ANXA1 and A5 mRNA levels were increased at 6 h. ANXA1 mRNA levels were higher in the 1 muM TPA than in the 10 nM TPA treatment, whereas 1 muM TPA did not show further stimulation of ANXA5 mRNA compared to 10 nM TPA.	Tetradecanoylphorbol Acetate	38-41	annexin A1	Mus musculus	43-48
34592416-5	2021	The PMA-treated S1P2knockout THP-1 Mphis showed decreases in IL-4/IL-13-induced phosphorylation of Janus-activated kinase (JAK) 1, JAK2, and STAT6 as well as mRNA expression of the M2 marker ARG1 compared with wild-type THP-1 Mphis.	Tetradecanoylphorbol Acetate	4-7	arginase 1	Homo sapiens	191-195
34958593-3	2022	Here, for the first time, we applied a CBT-Cys click condensation reaction to synthesize an acidity-initiated molecular probe (AIM-Probe, Cys(StBu)-Lys(Cy 5.5)-EDA-PMA-CBT), which could self-assemble into nanoparticles (AIM-NP) with self-quenched fluorescence under glutathione (GSH) reduction.	Tetradecanoylphorbol Acetate	164-167	ectodysplasin A	Homo sapiens	160-163
34645720-8	2022	After stimulation with 10 nM or 1 muM TPA, ANXA1 and A5 mRNA levels were increased at 6 h. ANXA1 mRNA levels were higher in the 1 muM TPA than in the 10 nM TPA treatment, whereas 1 muM TPA did not show further stimulation of ANXA5 mRNA compared to 10 nM TPA.	Tetradecanoylphorbol Acetate	38-41	annexin A1	Mus musculus	91-96
34645720-8	2022	After stimulation with 10 nM or 1 muM TPA, ANXA1 and A5 mRNA levels were increased at 6 h. ANXA1 mRNA levels were higher in the 1 muM TPA than in the 10 nM TPA treatment, whereas 1 muM TPA did not show further stimulation of ANXA5 mRNA compared to 10 nM TPA.	Tetradecanoylphorbol Acetate	134-137	annexin A1	Mus musculus	43-48
34645720-8	2022	After stimulation with 10 nM or 1 muM TPA, ANXA1 and A5 mRNA levels were increased at 6 h. ANXA1 mRNA levels were higher in the 1 muM TPA than in the 10 nM TPA treatment, whereas 1 muM TPA did not show further stimulation of ANXA5 mRNA compared to 10 nM TPA.	Tetradecanoylphorbol Acetate	134-137	annexin A1	Mus musculus	91-96
34751824-8	2022	Adam17 knockout decreased matrix metallopeptidase 13 (Mmp13) expression in both in vivo and in vitro experiments, whereas Adam17 activation by phorbol-12-myristate-13-acetate (PMA) increased Mmp13 and decreased aggrecan in mouse primary chondrocytes.	Tetradecanoylphorbol Acetate	143-174	matrix metallopeptidase 13	Mus musculus	191-196
34751824-8	2022	Adam17 knockout decreased matrix metallopeptidase 13 (Mmp13) expression in both in vivo and in vitro experiments, whereas Adam17 activation by phorbol-12-myristate-13-acetate (PMA) increased Mmp13 and decreased aggrecan in mouse primary chondrocytes.	Tetradecanoylphorbol Acetate	176-179	matrix metallopeptidase 13	Mus musculus	191-196
34437989-5	2021	The effect of PMA treatment was assayed on cell viability, caspase 3 activation, TNF-alpha and IL-1beta release and TNF receptor type I (TNFRI) and TNF receptor type II (TNFRII) levels.	Tetradecanoylphorbol Acetate	14-17	caspase 3	Rattus norvegicus	59-68
34437989-5	2021	The effect of PMA treatment was assayed on cell viability, caspase 3 activation, TNF-alpha and IL-1beta release and TNF receptor type I (TNFRI) and TNF receptor type II (TNFRII) levels.	Tetradecanoylphorbol Acetate	14-17	TNF receptor superfamily member 1B	Rattus norvegicus	148-168
34890758-6	2022	In MH-S alveolar macrophages, PMA-induced pro-inflammatory responses, including iNOS, COX-2, MMP-9 and cytokines expressions were reduced by cardamonin.	Tetradecanoylphorbol Acetate	30-33	cytochrome c oxidase II, mitochondrial	Mus musculus	86-91
34890758-6	2022	In MH-S alveolar macrophages, PMA-induced pro-inflammatory responses, including iNOS, COX-2, MMP-9 and cytokines expressions were reduced by cardamonin.	Tetradecanoylphorbol Acetate	30-33	matrix metallopeptidase 9	Mus musculus	93-98
34437989-5	2021	The effect of PMA treatment was assayed on cell viability, caspase 3 activation, TNF-alpha and IL-1beta release and TNF receptor type I (TNFRI) and TNF receptor type II (TNFRII) levels.	Tetradecanoylphorbol Acetate	14-17	TNF receptor superfamily member 1B	Rattus norvegicus	170-176
34645720-8	2022	After stimulation with 10 nM or 1 muM TPA, ANXA1 and A5 mRNA levels were increased at 6 h. ANXA1 mRNA levels were higher in the 1 muM TPA than in the 10 nM TPA treatment, whereas 1 muM TPA did not show further stimulation of ANXA5 mRNA compared to 10 nM TPA.	Tetradecanoylphorbol Acetate	156-159	annexin A1	Mus musculus	43-48
34437989-8	2021	PMA treatment also induces an increase in TNFRII levels while decreasing TNFRI after 24h.	Tetradecanoylphorbol Acetate	0-3	TNF receptor superfamily member 1B	Rattus norvegicus	42-48
34437989-9	2021	PMA also inhibited caspase-3 activation, and decreased ROS production and EthD-1/calcein ratio in retinal cell cultures leading to an increase in cell viability.	Tetradecanoylphorbol Acetate	0-3	caspase 3	Rattus norvegicus	19-28
34645720-8	2022	After stimulation with 10 nM or 1 muM TPA, ANXA1 and A5 mRNA levels were increased at 6 h. ANXA1 mRNA levels were higher in the 1 muM TPA than in the 10 nM TPA treatment, whereas 1 muM TPA did not show further stimulation of ANXA5 mRNA compared to 10 nM TPA.	Tetradecanoylphorbol Acetate	156-159	annexin A1	Mus musculus	91-96
34903321-8	2022	Moreover, the inhibition of aurora kinase A by siRNAs and inhibitors (reversine and VX-680) suppressed TPA-induced cell invasion, migration, and EMT in SW480 human colon cells.	Tetradecanoylphorbol Acetate	103-106	aurora kinase A	Homo sapiens	28-43
34645720-8	2022	After stimulation with 10 nM or 1 muM TPA, ANXA1 and A5 mRNA levels were increased at 6 h. ANXA1 mRNA levels were higher in the 1 muM TPA than in the 10 nM TPA treatment, whereas 1 muM TPA did not show further stimulation of ANXA5 mRNA compared to 10 nM TPA.	Tetradecanoylphorbol Acetate	185-188	annexin A1	Mus musculus	43-48
34645824-0	2021	Phorbol-12-myristate 13-acetate inhibits Nephronectin gene expression via Protein kinase C alpha and c-Jun/c-Fos transcription factors.	Tetradecanoylphorbol Acetate	0-31	jun proto-oncogene	Mus musculus	101-106
34645720-8	2022	After stimulation with 10 nM or 1 muM TPA, ANXA1 and A5 mRNA levels were increased at 6 h. ANXA1 mRNA levels were higher in the 1 muM TPA than in the 10 nM TPA treatment, whereas 1 muM TPA did not show further stimulation of ANXA5 mRNA compared to 10 nM TPA.	Tetradecanoylphorbol Acetate	254-257	annexin A1	Mus musculus	43-48
34248106-7	2021	Trans-palmitoleic acid and eicosapentaenoic acid (TPA and EPA) increased the phosphorylation level of MAPK/ERK1/2 and downregulated ROS generation and Tnfaip3 expression.	Tetradecanoylphorbol Acetate	50-53	TNF alpha induced protein 3	Homo sapiens	151-158
34503410-5	2021	Western blotting was performed to compare the expression levels of MMP-2 in phorbol 12-myristate 13-acetate (PMA)-induced HT-1080 cells.	Tetradecanoylphorbol Acetate	76-107	matrix metallopeptidase 2	Homo sapiens	67-72
34503410-5	2021	Western blotting was performed to compare the expression levels of MMP-2 in phorbol 12-myristate 13-acetate (PMA)-induced HT-1080 cells.	Tetradecanoylphorbol Acetate	109-112	matrix metallopeptidase 2	Homo sapiens	67-72
34529319-5	2021	Functional assays indicated that SNHG14 knockdown obviously hampered phorbol myristate acetate-activated THP-1 (pTHP-1) cell proliferation and proinflammatory cytokines production.	Tetradecanoylphorbol Acetate	69-94	small nucleolar RNA host gene 14	Homo sapiens	33-39
34071980-4	2021	A human monocytic leukemia cell line THP-1 was differentiated to CD14-positive macrophage-like cells by stimulation with PMA (phorbol 12-myristate 13-acetate) but not M1 or M2 types.	Tetradecanoylphorbol Acetate	121-124	CD14 molecule	Homo sapiens	65-69
34780714-5	2022	Although mRNA levels of inflammatory cytokines in skin after topical application of 12-O-tetradecanoylphorbol-13-acetate or imiquimod were comparable between kCYC+/- and wild-type mice, protein levels of inflammatory cytokines such as interleukin (IL)-17A, IL-22, and IL-23 were significantly upregulated in kCYC+/- mice in both models.	Tetradecanoylphorbol Acetate	84-120	interleukin 23, alpha subunit p19	Mus musculus	268-273
34374443-7	2021	APLME suppressed the activities of MMP-2 and MMP-9 in PMA (phorbol myristate acetate)-treated HT1080 cells.	Tetradecanoylphorbol Acetate	59-84	matrix metallopeptidase 2	Homo sapiens	35-40
34071980-4	2021	A human monocytic leukemia cell line THP-1 was differentiated to CD14-positive macrophage-like cells by stimulation with PMA (phorbol 12-myristate 13-acetate) but not M1 or M2 types.	Tetradecanoylphorbol Acetate	126-157	CD14 molecule	Homo sapiens	65-69
34078818-8	2021	Pressure loading that simulates systolic hypertension also reduced phorbol myristate 13-acetate (PMA) (a PKC activator)-induced COX-2 expression and the rapid and transient phosphorylation of ERK.	Tetradecanoylphorbol Acetate	97-100	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	128-133
34171483-9	2021	Integrin alpha6 and beta4 expression was also reduced when alpha2 expression was chemically induced using tetradecanoyl-phorbol-acetate (TPA).	Tetradecanoylphorbol Acetate	106-135	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	20-25
34171483-9	2021	Integrin alpha6 and beta4 expression was also reduced when alpha2 expression was chemically induced using tetradecanoyl-phorbol-acetate (TPA).	Tetradecanoylphorbol Acetate	137-140	immunoglobulin kappa variable 1D-27 (pseudogene)	Homo sapiens	20-25
34554562-7	2021	Lymphocyte viability was measured using a LIVE/DEAD assay, and function was assessed using mixed lymphocyte culture and CD69 expression post-phorbol-12 myristate 13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	174-177	CD69 molecule	Homo sapiens	120-124
34697988-0	2021	EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity.	Tetradecanoylphorbol Acetate	40-43	elongin A	Homo sapiens	0-4
34697988-6	2021	Knockdown of EloA in HEL cell line was shown to impair the phorbol myristate acetate (PMA) induced polyploidization process, which was used extensively to model megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	59-84	elongin A	Homo sapiens	13-17
35608955-4	2022	In contrast, following TCR-independent activation using PMA/ionomycin, neonatal cells demonstrated increased expression of CD69, IL-2 and TNF- alpha and equivalent phosphoERK compared to adult cells.	Tetradecanoylphorbol Acetate	56-59	CD69 molecule	Homo sapiens	123-127
34697988-6	2021	Knockdown of EloA in HEL cell line was shown to impair the phorbol myristate acetate (PMA) induced polyploidization process, which was used extensively to model megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	86-89	elongin A	Homo sapiens	13-17
34697988-10	2021	This study evidenced a positive role of EloA in HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity.	Tetradecanoylphorbol Acetate	74-77	elongin A	Homo sapiens	40-44
34542891-4	2022	Using human granulosa-like KGN cells, we confirmed that forskolin plus phorbol myristate acetate (PMA) which mimic the luteinizing hormone (LH) action induced the expression of WNT5A and cumulus expansion gene HAS2.	Tetradecanoylphorbol Acetate	71-96	hyaluronan synthase 2	Homo sapiens	210-214
34422811-7	2021	Results: Overexpression of lncRNA TPA decreased the expression of E-cadherin, and significantly increased the expression of Vimentin, fibronectin and TGF-beta1 (p < 0.01), and increased the migration rate, migration ability and invasion ability of cell group (P < 0.01).	Tetradecanoylphorbol Acetate	34-37	transforming growth factor, beta 1	Mus musculus	150-159
34344299-6	2021	We also observed that treatments with PMA or A23187 increase the synthesis of Ang1 (from 150 to 250%) in HC and this effect is amplified in T2DM and in all cohorts of HF patients.	Tetradecanoylphorbol Acetate	38-41	angiopoietin 1	Homo sapiens	78-82
35304248-7	2022	Notably, P2ry6 deletion prevented the TPA-induced increase in YAP nuclear accumulation and its downstream gene expression in an MST/LATS1-dependent manner.	Tetradecanoylphorbol Acetate	38-41	yes-associated protein 1	Mus musculus	62-65
34339458-4	2021	We demonstrate that depletion of either YAP or TAZ inhibits the ability of phorbol ester (TPA) treatment, cellular differentiation or the EBV BRLF1 immediate-early (IE) protein to induce lytic EBV reactivation in oral keratinocytes, and show that over-expression of constitutively active forms of YAP and TAZ reactivate lytic EBV infection in conjunction with TEAD family members.	Tetradecanoylphorbol Acetate	90-93	Yes1 associated transcriptional regulator	Homo sapiens	40-43
34542891-4	2022	Using human granulosa-like KGN cells, we confirmed that forskolin plus phorbol myristate acetate (PMA) which mimic the luteinizing hormone (LH) action induced the expression of WNT5A and cumulus expansion gene HAS2.	Tetradecanoylphorbol Acetate	98-101	hyaluronan synthase 2	Homo sapiens	210-214
35304248-7	2022	Notably, P2ry6 deletion prevented the TPA-induced increase in YAP nuclear accumulation and its downstream gene expression in an MST/LATS1-dependent manner.	Tetradecanoylphorbol Acetate	38-41	large tumor suppressor	Mus musculus	132-137
35304248-9	2022	Moreover, mutual promotion of the YAP and beta-catenin signaling pathways was observed in normal skin cells treated with TPA, while P2ry6 deletion could inhibit their crosstalk by regulating MEK1.	Tetradecanoylphorbol Acetate	121-124	yes-associated protein 1	Mus musculus	34-37
34632188-8	2021	In conclusion, 1,4-naphthoquinone is an effective inhibitor of IRAK1 kinases and their mediated inflammatory cytokines production in LPS-stimulated PMA-induced human THP-1 macrophages.	Tetradecanoylphorbol Acetate	148-151	interleukin 1 receptor associated kinase 1	Homo sapiens	63-68
34760627-9	2021	In our recent report, we found that PKCdelta-mediated ROS generation may interfere with the association of RKIP with heat shock protein 60 (HSP60)/MAPK complex via oxidation of HSP60 triggered by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	215-252	protein kinase C delta	Homo sapiens	36-44
35484745-7	2022	These newly generated AuNPs-CIT nanoparticles inhibited PMA-induced activation and nuclear translocation of NF-kappaB p65 in MCF-7 cells.	Tetradecanoylphorbol Acetate	56-59	RELA proto-oncogene, NF-kB subunit	Homo sapiens	108-121
35625931-5	2022	Compared to WT PMNs, Pkm2-deficient (Pkm2-/-) PMNs displayed significantly less capacity for fMLP- or PMA-induced degranulation of secondary and tertiary granules, ROS production, and transfilter migration.	Tetradecanoylphorbol Acetate	102-105	pyruvate kinase, muscle	Mus musculus	21-25
35625931-5	2022	Compared to WT PMNs, Pkm2-deficient (Pkm2-/-) PMNs displayed significantly less capacity for fMLP- or PMA-induced degranulation of secondary and tertiary granules, ROS production, and transfilter migration.	Tetradecanoylphorbol Acetate	102-105	pyruvate kinase, muscle	Mus musculus	37-41
34344445-13	2021	In LP cells, significant induction of Wnt4 and Rankl, and Wnt pathway intermediates Lrp2 and Axin2 (confirmed by qRTPCR) were reversed by TPA and MFP (p < 0.0001).	Tetradecanoylphorbol Acetate	138-141	wingless-type MMTV integration site family, member 4	Mus musculus	38-42
34344445-13	2021	In LP cells, significant induction of Wnt4 and Rankl, and Wnt pathway intermediates Lrp2 and Axin2 (confirmed by qRTPCR) were reversed by TPA and MFP (p < 0.0001).	Tetradecanoylphorbol Acetate	138-141	wingless-type MMTV integration site family, member 4	Mus musculus	58-61
34538821-8	2022	TPA-induced plasmin activity was evaluated in the presence of the alpha-globin chain.	Tetradecanoylphorbol Acetate	0-3	plasminogen	Homo sapiens	12-19
35526705-12	2022	CONCLUSIONS: Combining Mel and Zn supplements with PMA defends against AlCl3-induced AD by modulating GSK-3beta-Wnt/beta-catenin signaling and palliates the associated hepatorenal dysfunction.	Tetradecanoylphorbol Acetate	51-54	glycogen synthase kinase 3 alpha	Rattus norvegicus	102-111
35471587-7	2022	An inducer of keratinocyte differentiation, phorbol 12-myristate 13-acetate (PMA), also diminished TXNIP expression, which was reversed by PKC-delta knockdown.	Tetradecanoylphorbol Acetate	44-75	protein kinase C delta	Homo sapiens	139-148
35471587-7	2022	An inducer of keratinocyte differentiation, phorbol 12-myristate 13-acetate (PMA), also diminished TXNIP expression, which was reversed by PKC-delta knockdown.	Tetradecanoylphorbol Acetate	77-80	protein kinase C delta	Homo sapiens	139-148
35471587-10	2022	Furthermore, PMA-induced PKC-delta phosphorylation, TGF-alpha, and EGF-triggered EGFR phosphorylation were attenuated by TXNIP knockdown.	Tetradecanoylphorbol Acetate	13-16	protein kinase C delta	Homo sapiens	25-34
35513847-9	2022	PBMCs produced high levels of IFN-gamma, IL-4, and IL-17A after stimulation with PMA/Ionomycin and Con A.	Tetradecanoylphorbol Acetate	81-84	interleukin-17A	Ovis aries	51-57
2562123-3	1989	The proto-oncogenes jun B, c-fos, and to a lesser extent jun D were stimulated by increasing the intracellular concentration of cAMP, whereas the TPA stimulation of c-jun and c-myc was inhibited under these conditions.	Tetradecanoylphorbol Acetate	146-149	jun proto-oncogene	Mus musculus	165-170
35471587-10	2022	Furthermore, PMA-induced PKC-delta phosphorylation, TGF-alpha, and EGF-triggered EGFR phosphorylation were attenuated by TXNIP knockdown.	Tetradecanoylphorbol Acetate	13-16	transforming growth factor alpha	Homo sapiens	52-61
35151470-10	2022	Furthermore, following the challenge with PMA, thapsigargin increased NET formation and ROS production, but blocking ORAI1 with 2APB decreased NADPH oxidase activation, ROS production, and NET formation.	Tetradecanoylphorbol Acetate	42-45	ORAI calcium release-activated calcium modulator 1	Bos taurus	117-122
2558432-4	1989	While EGF, basic fibroblast growth factor, insulin, insulin-like growth factor-1, and transforming growth factor beta all decreased cAMP production only, TPA decreased hCG-stimulated cAMP and progesterone production.	Tetradecanoylphorbol Acetate	154-157	chorionic gonadotropin subunit beta 5	Homo sapiens	168-171
35068054-4	2022	Furthermore, PPP2CB deletion did not affect T cell receptor (TCR)-induced T cell activation or cytokine-induced T cell responses; however, it specifically enhanced phorbol myristate acetate (PMA) plus ionomycin-induced T cell activation with increased cellular proliferation, elevated CD69 and CD25 expression, and enhanced cytokines production (IFN-gamma, IL-2 and TNF).	Tetradecanoylphorbol Acetate	164-189	CD69 antigen	Mus musculus	285-289
35047356-10	2022	IOP TPA measures are predictive of cGAT values, adjusted according to anterior chamber depth and corneal astigmatism.	Tetradecanoylphorbol Acetate	4-7	solute carrier family 18 member A1	Homo sapiens	35-39
2558432-6	1989	In addition, EGF, insulin, and TPA, like hCG, elevated mRNA levels of competence oncogenes (c-fos and c-myc), albeit to different extents.	Tetradecanoylphorbol Acetate	31-34	chorionic gonadotropin subunit beta 5	Homo sapiens	41-44
2597139-4	1989	In stirred platelets, total and specific inhibition of PMA-induced aggregation by a fibrinogen-derived peptide (RGDS, i.e. Arg-Gly-Asp-Ser) promoted maximal increases in membrane-associated PKC in the presence of PMA and completely prevented the loss in cellular activity.	Tetradecanoylphorbol Acetate	55-58	ral guanine nucleotide dissociation stimulator	Homo sapiens	112-116
2556264-7	1989	However, in contrast to the TC-II enhanson, the H-2Kb enhanson exhibits a very low activity in HeLa cells, but can be strongly induced by TPA and/or cycloheximide treatments which suggests that its cognate factor is inactivated (repressed) by an inhibitor protein.	Tetradecanoylphorbol Acetate	138-141	transcobalamin 2	Homo sapiens	28-33
2533503-6	1989	Phorbol myristate acetate (PMA) induces Tac antigen expression in RASF but does not lead to proliferation.	Tetradecanoylphorbol Acetate	0-25	interleukin 2 receptor subunit alpha	Homo sapiens	40-51
2597139-4	1989	In stirred platelets, total and specific inhibition of PMA-induced aggregation by a fibrinogen-derived peptide (RGDS, i.e. Arg-Gly-Asp-Ser) promoted maximal increases in membrane-associated PKC in the presence of PMA and completely prevented the loss in cellular activity.	Tetradecanoylphorbol Acetate	213-216	ral guanine nucleotide dissociation stimulator	Homo sapiens	112-116
2790804-0	1989	Independent mechanisms for tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in reduction of epidermal growth factor binding by rat hepatocytes.	Tetradecanoylphorbol Acetate	61-97	epidermal growth factor like 1	Rattus norvegicus	114-137
2533503-6	1989	Phorbol myristate acetate (PMA) induces Tac antigen expression in RASF but does not lead to proliferation.	Tetradecanoylphorbol Acetate	27-30	interleukin 2 receptor subunit alpha	Homo sapiens	40-51
2818583-2	1989	Induction of the expressions of these IL-2R subunits was examined by the protein kinase-C (PK-C) activator (phorbol myristate acetate, PMA) and the calcium ionophore, ionomycine (IM).	Tetradecanoylphorbol Acetate	108-133	interleukin 2 receptor subunit alpha	Homo sapiens	38-43
2481153-7	1989	However, the secreted tPA was composed mostly of an inactive form of tPA.PAI-1 complex, and the PA activity was derived mostly from uPA.	Tetradecanoylphorbol Acetate	22-25	serpin family E member 1	Bos taurus	73-78
2818583-2	1989	Induction of the expressions of these IL-2R subunits was examined by the protein kinase-C (PK-C) activator (phorbol myristate acetate, PMA) and the calcium ionophore, ionomycine (IM).	Tetradecanoylphorbol Acetate	135-138	interleukin 2 receptor subunit alpha	Homo sapiens	38-43
2478272-5	1989	When the cells were treated with a phorbol ester (TPA), the down-regulation of ODC was preceded by a transient increase in the steady-state levels of this RNA.	Tetradecanoylphorbol Acetate	50-53	ornithine decarboxylase 1	Homo sapiens	79-82
2590210-7	1989	At low concentrations, K252a appears to slightly activate further TPA-activated p76-kinase.	Tetradecanoylphorbol Acetate	66-69	phospholipase B domain containing 2	Mus musculus	80-83
2807372-10	1989	Nevertheless, the majority of both purified CD1- and CD3- thymocytes expressed AIM antigen after treatment with PMA.	Tetradecanoylphorbol Acetate	112-115	CD1c molecule	Homo sapiens	44-47
2574679-5	1989	Similarly to plastic-adsorbed antibodies, phorbol myristic acetate (PMA) or a combination of PMA and the calcium ionophore Ionomycin also induces secretion of growth factors without inducing proliferation, but in this case addition of IL 1 is ineffective in inducing AK-8 proliferation.	Tetradecanoylphorbol Acetate	68-71	interleukin 1 complex	Mus musculus	235-239
2684703-5	1989	Simultaneous infusions of ionomycin and PMA resulted in an initial, protein synthesis-independent response followed by the secondary, augmented, protein synthesis-dependent component, which exhibited synergistic interactions between calmodulin and PKC.	Tetradecanoylphorbol Acetate	40-43	calmodulin 1	Rattus norvegicus	233-243
2691880-12	1989	Finally, methimazole and phorbol 12-myristate 13-acetate show different effects on TSH-induced increases in thyroglobulin and thyroid peroxidase mRNA levels.	Tetradecanoylphorbol Acetate	25-56	thyroid peroxidase	Rattus norvegicus	126-144
2777774-2	1989	p31 was also synthesized in response to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	40-76	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	0-3
2777774-2	1989	p31 was also synthesized in response to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	78-81	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	0-3
2501296-12	1989	Similarly, TRH increased incorporation of [3H] serine into sphingomyelin to 145 +/- 8% of control after 3 h. TPA also stimulated these events.	Tetradecanoylphorbol Acetate	109-112	thyrotropin releasing hormone	Rattus norvegicus	11-14
2777774-3	1989	V8 protease digestion of p31 purified from PDGF-, TPA-, and arsenite-treated cells showed identical fragmentation patterns, demonstrating that these agents modulate synthesis of the same (or a highly similar) protein.	Tetradecanoylphorbol Acetate	50-53	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	25-28
2777774-4	1989	TPA-induced p31 synthesis was cell cycle-specific, occurring in density-arrested but not exponentially replicating cells.	Tetradecanoylphorbol Acetate	0-3	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	12-15
2777774-13	1989	Stimulation of p31 synthesis by growth factors, PDGF and fibroblast growth factor; a tumor promoter, TPA; and heavy metal salts suggests that there is overlap in the pathways for mitogenic stimulation and heavy metal stress.	Tetradecanoylphorbol Acetate	101-104	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	15-18
2502025-5	1989	Phosphorylation of pp36 and pp28 were mimicked by the protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA) and the calcium ionophore, ionomycin, respectively.	Tetradecanoylphorbol Acetate	82-118	linker for activation of T cells	Homo sapiens	19-23
2551727-3	1989	The retinoic acid-induced differentiation of HL-60 cells was, but the Bt2cAMP- or PMA-induced one was not, inhibited by prior exposure of the cells to islet-activating protein (IAP), pertussis toxin.	Tetradecanoylphorbol Acetate	82-85	islet amyloid polypeptide	Homo sapiens	177-180
2502025-5	1989	Phosphorylation of pp36 and pp28 were mimicked by the protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA) and the calcium ionophore, ionomycin, respectively.	Tetradecanoylphorbol Acetate	120-123	linker for activation of T cells	Homo sapiens	19-23
2544397-7	1989	Cotreatment of a saturating dose of EGF with phorbol myristate acetate (PMA) or GnRH resulted in additive increases in both tPA enzyme activity and mRNA levels.	Tetradecanoylphorbol Acetate	45-70	epidermal growth factor like 1	Rattus norvegicus	36-39
2790038-7	1989	Chronic exposure to TPA resulted in down-regulation of PKC enzyme activity in both cell lines, and a selective decrease in PKC-beta RNA transcripts in both cell types.	Tetradecanoylphorbol Acetate	20-23	protein kinase C beta	Homo sapiens	123-131
2790038-9	1989	Our results indicate a correlation between the level of PKC-beta expression and the responsiveness of myeloid lineage precursor cells to the differentiative effects of TPA.	Tetradecanoylphorbol Acetate	168-171	protein kinase C beta	Homo sapiens	56-64
35460166-9	2022	As predicted by the in silico analyses, PpT-2 scavenged free radicals in vitro and suppressed the generation of reactive species in PMA-stimulated BV-2 microglia cells.	Tetradecanoylphorbol Acetate	132-135	palmitoyl-protein thioesterase 2	Mus musculus	40-45
2544397-7	1989	Cotreatment of a saturating dose of EGF with phorbol myristate acetate (PMA) or GnRH resulted in additive increases in both tPA enzyme activity and mRNA levels.	Tetradecanoylphorbol Acetate	72-75	epidermal growth factor like 1	Rattus norvegicus	36-39
2547580-0	1989	Induction of type II 5"-deiodinase activity in cultured rat astroglial cells by 12-O-tetradecanoylphorbol-13-acetate: dependence on glucocorticoids.	Tetradecanoylphorbol Acetate	80-116	iodothyronine deiodinase 2	Rattus norvegicus	13-34
2544397-8	1989	In addition, pretreatment with PMA desensitized the cells to subsequent treatment with PMA or GnRH, but did not diminish EGF-induced tPA mRNA, suggesting that EGF acts through a pathway independent of protein kinase-C. Also, extracellular cAMP levels did not increase with EGF treatment in the presence or absence of a phosphodiesterase inhibitor, suggesting the lack of involvement of the protein kinase-A pathway.	Tetradecanoylphorbol Acetate	31-34	epidermal growth factor like 1	Rattus norvegicus	159-162
35230372-9	2022	MUG1 blunted while Lgals3 amplified neutrophil degranulation in response to phorbol 12-myristate 13-acetate or interleukin-1beta, as measured by MMP-9 secretion.	Tetradecanoylphorbol Acetate	76-107	galectin 3	Homo sapiens	19-25
35127555-9	2021	Higher level of CD69, ICOS and PD-1, lower level of CD62L, and decreased IFN-gamma producing after stimulation by PMA and ionomycin were found in gammadeltaT cells from infected mice, compared with naive mice.	Tetradecanoylphorbol Acetate	114-117	CD69 antigen	Mus musculus	16-20
2788076-2	1989	In normal cells, a mixture of hypothalamic hormones induced, like the tumor promoter 12-O-tetradecanoylphorbol-13-acetate, stronger phosphorylation changes than TRH alone.	Tetradecanoylphorbol Acetate	85-121	thyrotropin releasing hormone	Rattus norvegicus	161-164
2544397-8	1989	In addition, pretreatment with PMA desensitized the cells to subsequent treatment with PMA or GnRH, but did not diminish EGF-induced tPA mRNA, suggesting that EGF acts through a pathway independent of protein kinase-C. Also, extracellular cAMP levels did not increase with EGF treatment in the presence or absence of a phosphodiesterase inhibitor, suggesting the lack of involvement of the protein kinase-A pathway.	Tetradecanoylphorbol Acetate	31-34	epidermal growth factor like 1	Rattus norvegicus	159-162
34538821-11	2022	The PLG and alpha-globin chain had interaction kinetics similar to tPA:PLG, and the alpha-globin chain increased tPA-induced plasmin activity.	Tetradecanoylphorbol Acetate	67-70	plasminogen	Homo sapiens	125-132
2544397-8	1989	In addition, pretreatment with PMA desensitized the cells to subsequent treatment with PMA or GnRH, but did not diminish EGF-induced tPA mRNA, suggesting that EGF acts through a pathway independent of protein kinase-C. Also, extracellular cAMP levels did not increase with EGF treatment in the presence or absence of a phosphodiesterase inhibitor, suggesting the lack of involvement of the protein kinase-A pathway.	Tetradecanoylphorbol Acetate	87-90	epidermal growth factor like 1	Rattus norvegicus	159-162
34538821-11	2022	The PLG and alpha-globin chain had interaction kinetics similar to tPA:PLG, and the alpha-globin chain increased tPA-induced plasmin activity.	Tetradecanoylphorbol Acetate	113-116	hemoglobin subunit alpha 2	Homo sapiens	84-96
2544397-8	1989	In addition, pretreatment with PMA desensitized the cells to subsequent treatment with PMA or GnRH, but did not diminish EGF-induced tPA mRNA, suggesting that EGF acts through a pathway independent of protein kinase-C. Also, extracellular cAMP levels did not increase with EGF treatment in the presence or absence of a phosphodiesterase inhibitor, suggesting the lack of involvement of the protein kinase-A pathway.	Tetradecanoylphorbol Acetate	87-90	epidermal growth factor like 1	Rattus norvegicus	159-162
34538821-11	2022	The PLG and alpha-globin chain had interaction kinetics similar to tPA:PLG, and the alpha-globin chain increased tPA-induced plasmin activity.	Tetradecanoylphorbol Acetate	113-116	plasminogen	Homo sapiens	125-132
2769792-2	1989	: Oncogene 1:263-270, 1987) mRNAs in secondary cultures of rat neocortical astrocytes was much greater in response to tetradecanoyl phorbol acetate (TPA) than in response to either epidermal growth factor (EGF) or fibroblast growth factor (FGF).	Tetradecanoylphorbol Acetate	149-152	epidermal growth factor like 1	Rattus norvegicus	206-209
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Tetradecanoylphorbol Acetate	136-139	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	42-46
2474594-2	1989	Treatment with PMA or OAG caused down-regulation of the TCR-CD3 complex, but only PMA, in combination with ionomycin, was capable of stimulating IL-2R expression and proliferation.	Tetradecanoylphorbol Acetate	82-85	interleukin 2 receptor subunit alpha	Homo sapiens	145-150
2769792-6	1989	In contrast, when either EGF or FGF was presented to astrocytes in combination with maximally inducing levels of TPA, the resulting levels of accumulation of TIS mRNAs were at least as great as the sum of the levels induced by the individual mitogens.	Tetradecanoylphorbol Acetate	113-116	epidermal growth factor like 1	Rattus norvegicus	25-28
2528680-1	1989	The turnover of the colony-stimulating factor 1 receptor (CSF-1R), the c-fms proto-oncogene product, is accelerated by ligand binding or by activators of protein kinase C (PKC), such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	204-240	colony stimulating factor 1 receptor	Homo sapiens	20-56
2681516-3	1989	Previous experiments had shown that BMM treated with PMA were stimulated to accumulate LY, but compared with rM-CSF-treated cells, the onset of stimulation in PMA-treated macrophages was slower.	Tetradecanoylphorbol Acetate	159-162	colony stimulating factor 1	Rattus norvegicus	109-115
2681516-4	1989	In further comparisons of rM-CSF- and PMA-stimulated LY accumulation, it was found that rM-CSF-stimulated pinocytosis could be abolished by pretreatment with 0.5 mg/ml trypsin, whereas neither unstimulated nor PMA-stimulated LY accumulation was affected by trypsin pretreatment.	Tetradecanoylphorbol Acetate	38-41	colony stimulating factor 1	Rattus norvegicus	88-94
2528680-1	1989	The turnover of the colony-stimulating factor 1 receptor (CSF-1R), the c-fms proto-oncogene product, is accelerated by ligand binding or by activators of protein kinase C (PKC), such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	204-240	colony stimulating factor 1 receptor	Homo sapiens	58-64
2681516-7	1989	First, rM-CSF-treated cells, like PMA-treated cells, showed extensive ruffling and formation of large phase-bright pinosomes.	Tetradecanoylphorbol Acetate	34-37	colony stimulating factor 1	Rattus norvegicus	7-13
2528680-1	1989	The turnover of the colony-stimulating factor 1 receptor (CSF-1R), the c-fms proto-oncogene product, is accelerated by ligand binding or by activators of protein kinase C (PKC), such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	204-240	colony stimulating factor 1 receptor	Homo sapiens	71-76
2681516-9	1989	Finally, rM-CSF, like PMA, was found to stimulate efflux of LY from cells preloaded with the dye.	Tetradecanoylphorbol Acetate	22-25	colony stimulating factor 1	Rattus norvegicus	9-15
2528680-1	1989	The turnover of the colony-stimulating factor 1 receptor (CSF-1R), the c-fms proto-oncogene product, is accelerated by ligand binding or by activators of protein kinase C (PKC), such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	242-245	colony stimulating factor 1 receptor	Homo sapiens	20-56
2528680-1	1989	The turnover of the colony-stimulating factor 1 receptor (CSF-1R), the c-fms proto-oncogene product, is accelerated by ligand binding or by activators of protein kinase C (PKC), such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	242-245	colony stimulating factor 1 receptor	Homo sapiens	58-64
2528680-1	1989	The turnover of the colony-stimulating factor 1 receptor (CSF-1R), the c-fms proto-oncogene product, is accelerated by ligand binding or by activators of protein kinase C (PKC), such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	242-245	colony stimulating factor 1 receptor	Homo sapiens	71-76
2528680-3	1989	First, in cells in which PKC was downmodulated, CSF-1R reexpressed at the cell surface remained sensitive to ligand but was refractory to TPA-induced degradation.	Tetradecanoylphorbol Acetate	138-141	colony stimulating factor 1 receptor	Homo sapiens	48-54
2530580-6	1989	Activation of phospholipid/Ca2+-dependent protein kinase, protein kinase C, by phorbol 12-myristate 13-acetate (PMA) greatly reduced the number of IL-1 binding sites on 70Z/3.	Tetradecanoylphorbol Acetate	79-110	interleukin 1 complex	Mus musculus	147-151
2540858-7	1989	However, a mixture of hrIL-1 alpha and hrIL-1 beta reproduced the ability of mIL-1 to inhibit the oxidative response to suboptimal doses of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	140-165	interleukin 1 complex	Mus musculus	77-82
2530580-6	1989	Activation of phospholipid/Ca2+-dependent protein kinase, protein kinase C, by phorbol 12-myristate 13-acetate (PMA) greatly reduced the number of IL-1 binding sites on 70Z/3.	Tetradecanoylphorbol Acetate	112-115	interleukin 1 complex	Mus musculus	147-151
2551067-1	1989	The cytoplasmic pH (pHc) of human platelets was lowered to 6.8-7.2 by treatment with various doses of nigericin (K+/H+ ionophore), then these platelets were stimulated with thrombin, arachidonic acid (AA), A23187 or 12-o-tetradecanoylphorbol-13-acetate (TPA), to monitor the pHc changes using a pH-sensitive fluorescent dye, BCECF.	Tetradecanoylphorbol Acetate	216-252	solute carrier family 25 member 3	Homo sapiens	20-23
2551067-1	1989	The cytoplasmic pH (pHc) of human platelets was lowered to 6.8-7.2 by treatment with various doses of nigericin (K+/H+ ionophore), then these platelets were stimulated with thrombin, arachidonic acid (AA), A23187 or 12-o-tetradecanoylphorbol-13-acetate (TPA), to monitor the pHc changes using a pH-sensitive fluorescent dye, BCECF.	Tetradecanoylphorbol Acetate	254-257	solute carrier family 25 member 3	Homo sapiens	20-23
2551067-2	1989	The pHc increased with the stimulation in an amiloride-sensitive manner only when the resting-pHc was lower than a certain value (pHc 6.99 for thrombin-stimulation, 6.95 for AA, 7.04 for A23187 and 6.95 for TPA, n = 3).	Tetradecanoylphorbol Acetate	207-210	solute carrier family 25 member 3	Homo sapiens	4-7
2540858-7	1989	However, a mixture of hrIL-1 alpha and hrIL-1 beta reproduced the ability of mIL-1 to inhibit the oxidative response to suboptimal doses of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	167-170	interleukin 1 complex	Mus musculus	77-82
2504580-4	1989	Truncated c-Jun and JunD proteins containing the C-terminus recognize the same DNA sequences which were defined as the PEA1/AP1 binding sequence or TPA response element (TRE).	Tetradecanoylphorbol Acetate	148-151	jun proto-oncogene	Mus musculus	10-15
2760031-9	1989	During this process PTA1 is also phosphorylated, as it is following platelet activation by the other agonists, collagen, thrombin, and 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	135-171	CD226 molecule	Homo sapiens	20-24
2743312-0	1989	Lack of a role of DNA methylation in tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced synthesis of ornithine decarboxylase messenger RNA in T24 cells.	Tetradecanoylphorbol Acetate	52-88	ornithine decarboxylase 1	Homo sapiens	110-133
2743312-1	1989	Association of alteration in DNA methylation pattern in triggering 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcription of ornithine decarboxylase (ODC) gene in T24 cells was determined.	Tetradecanoylphorbol Acetate	67-103	ornithine decarboxylase 1	Homo sapiens	135-158
2504580-6	1989	Contrary to c-jun and junB transcription, which are strongly stimulated by serum or TPA treatment of quiescent 3T3 cells, junD transcription is not significantly stimulated in these conditions.	Tetradecanoylphorbol Acetate	84-87	jun proto-oncogene	Mus musculus	12-17
2743312-1	1989	Association of alteration in DNA methylation pattern in triggering 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcription of ornithine decarboxylase (ODC) gene in T24 cells was determined.	Tetradecanoylphorbol Acetate	67-103	ornithine decarboxylase 1	Homo sapiens	160-163
2544432-1	1989	Monoclonal antibodies (mAb) against CD3 or CD28 in conjunction with the tumor promoter phorbol 12-myristate 13-acetate (PMA) induce interleukin 2 receptor (IL2R) expression, IL2 production and proliferation in resting T cells.	Tetradecanoylphorbol Acetate	87-118	interleukin 2 receptor subunit alpha	Homo sapiens	156-160
2743312-1	1989	Association of alteration in DNA methylation pattern in triggering 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcription of ornithine decarboxylase (ODC) gene in T24 cells was determined.	Tetradecanoylphorbol Acetate	105-108	ornithine decarboxylase 1	Homo sapiens	135-158
2743312-1	1989	Association of alteration in DNA methylation pattern in triggering 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcription of ornithine decarboxylase (ODC) gene in T24 cells was determined.	Tetradecanoylphorbol Acetate	105-108	ornithine decarboxylase 1	Homo sapiens	160-163
2743312-4	1989	Biophys., 262: 326-336, 1988), TPA treatment of T24 cells, cultured in serum-free medium, resulted in a dramatic (approximately 15-fold) increase in ODC activity which was accompanied by a proportional increase in hybridizable amount of ODC mRNA.	Tetradecanoylphorbol Acetate	31-34	ornithine decarboxylase 1	Homo sapiens	149-152
2743312-4	1989	Biophys., 262: 326-336, 1988), TPA treatment of T24 cells, cultured in serum-free medium, resulted in a dramatic (approximately 15-fold) increase in ODC activity which was accompanied by a proportional increase in hybridizable amount of ODC mRNA.	Tetradecanoylphorbol Acetate	31-34	ornithine decarboxylase 1	Homo sapiens	237-240
2544432-1	1989	Monoclonal antibodies (mAb) against CD3 or CD28 in conjunction with the tumor promoter phorbol 12-myristate 13-acetate (PMA) induce interleukin 2 receptor (IL2R) expression, IL2 production and proliferation in resting T cells.	Tetradecanoylphorbol Acetate	120-123	CD28 molecule	Homo sapiens	43-47
2743312-5	1989	Data from nuclear run-off transcription assay revealed that TPA-induced accumulation of ODC mRNA is the result of increased transcription initiation.	Tetradecanoylphorbol Acetate	60-63	ornithine decarboxylase 1	Homo sapiens	88-91
2743312-6	1989	Since DNA hypomethylation has been proposed to be a mechanism involved in the regulation of transcription of some gene(s), we examined the changes in the methylation patterns in the ODC gene isolated from the vehicle (ethanol)- and TPA-treated T24 cells.	Tetradecanoylphorbol Acetate	232-235	ornithine decarboxylase 1	Homo sapiens	182-185
2544432-1	1989	Monoclonal antibodies (mAb) against CD3 or CD28 in conjunction with the tumor promoter phorbol 12-myristate 13-acetate (PMA) induce interleukin 2 receptor (IL2R) expression, IL2 production and proliferation in resting T cells.	Tetradecanoylphorbol Acetate	120-123	interleukin 2 receptor subunit alpha	Homo sapiens	156-160
2784064-5	1989	In the presence of the phorbol ester TPA, leukemic blasts from two cases differentiated along the B precursor pathway to the [CD2-CD10+CD19+CD20+C mu+slg-] pre-B cell stage.	Tetradecanoylphorbol Acetate	37-40	CD19 molecule	Homo sapiens	135-139
2547940-4	1989	Cells exposed to dexamethasone (10(-6) M) released equal or greater quantities of the lysosomal enzymes, lysozyme and beta-glucuronidase in response to formylmethionyl-leucyl-phenylalanine, serum activated zymosan, and the tumor promoting phorbol diester 12-O-tetradecanoylphorbol-13-acetate compared to controls.	Tetradecanoylphorbol Acetate	255-291	glucuronidase beta	Homo sapiens	118-136
2914963-3	1989	Phorbol 12-myristate 13-acetate (PMA) can activate protein kinase C and induce ornithine decarboxylase in PC12 cells with kinetics which are similar to those of NGF induction, but only to levels about 10-fold lower.	Tetradecanoylphorbol Acetate	33-36	nerve growth factor	Rattus norvegicus	161-164
2736628-6	1989	The inductive capacity of TGF-beta 1 appeared specific since other agents such as phorbol myristate acetate and endotoxin failed to induce fibronectin production.	Tetradecanoylphorbol Acetate	82-107	transforming growth factor, beta 1	Mus musculus	26-36
2722855-0	1989	Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis.	Tetradecanoylphorbol Acetate	85-121	secreted phosphoprotein 1	Mus musculus	0-11
2537468-7	1989	This prolonged induction of jun contrasts with its transient activation by the phorbol ester TPA and provides a physiological example of the ability of jun/AP-1 to stimulate its own transcription.	Tetradecanoylphorbol Acetate	93-96	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	156-160
2548081-3	1989	Identical results were obtained with the human natural killer-like cell line YT, which can be induced to express the interleukin-2 receptor alpha subunit in response to interleukin-1, cyclic AMP, or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	199-230	interleukin 2 receptor subunit alpha	Homo sapiens	117-145
2785992-3	1989	Despite the presence of cycloheximide or anisomycin at concentrations sufficient to block greater than 97% of cellular protein synthesis, phytohemagglutinin and phorbol 12-myristate 13-acetate effectively induced the expression of the IL-2R alpha gene as measured at the mRNA level.	Tetradecanoylphorbol Acetate	161-192	interleukin 2 receptor subunit alpha	Homo sapiens	235-246
2565932-3	1989	Although the latter cells strongly proliferate in response to phorbol myristate acetate (PMA) + ionomycin, DETC, when exposed to interleukin-1 (IL-1), interleukin-3 (IL-3), concanavalin A (ConA), PMA, and ionomycin used either alone or in combination, do not exhibit significant mitotic activity.	Tetradecanoylphorbol Acetate	89-92	interleukin 1 complex	Mus musculus	144-148
2766409-4	1989	Results obtained in this way showed that the double bond at C-2 and C-3 of the flavonoid structure is a prerequisite for anti-tumor-promoting activity, and indicated that activity in this screening assay for inhibitors of TPA-induced ear edema reflects the anti-tumor-promoting effect in two-stage carcinogenesis.	Tetradecanoylphorbol Acetate	222-225	complement component 3	Mus musculus	68-71
2521857-2	1989	We now show that the MDA468 breast cancer cells express the mRNA for the EGF-like molecule, transforming growth factor-alpha (TGF-alpha), and demonstrate that TPA or EGF cause an accumulation of both EGF receptor and TGF-alpha mRNA.	Tetradecanoylphorbol Acetate	159-162	transforming growth factor alpha	Homo sapiens	126-135
2521857-2	1989	We now show that the MDA468 breast cancer cells express the mRNA for the EGF-like molecule, transforming growth factor-alpha (TGF-alpha), and demonstrate that TPA or EGF cause an accumulation of both EGF receptor and TGF-alpha mRNA.	Tetradecanoylphorbol Acetate	159-162	transforming growth factor alpha	Homo sapiens	217-226
2537356-9	1989	Ecto-5"-NT+ T cells responded to lower doses of PMA (1.0 ng/ml) than did ecto-5"-NT- T cells and showed a two- to eight-fold greater rate of [3H]TdR incorporation at 3 to 10 ng of PMA per ml.	Tetradecanoylphorbol Acetate	48-51	5'-nucleotidase ecto	Homo sapiens	0-10
2537356-10	1989	Ecto-5"-NT+ T cells may have a protein kinase C that is more accessible or more easily activated or may utilize an alternate pathway of activation when stimulated with low concentrations of PMA.	Tetradecanoylphorbol Acetate	190-193	5'-nucleotidase ecto	Homo sapiens	0-10
2546062-9	1989	Both 8-CPT-cAMP and EGF were also equally effective in causing a rapid and transient induction of c-fos and c-myc protooncogene mRNA levels when added to growth-arrested H4IIE cells while A23187, N-(Bu)2-cAMP, and 4 beta-phorbol 12-myristate 13-acetate were significantly less effective.	Tetradecanoylphorbol Acetate	216-252	epidermal growth factor like 1	Rattus norvegicus	20-23
2523515-6	1989	The half-life of c-fms transcripts in TPA-induced HL-60 cells was found to be at least 6 h, while inhibition of protein synthesis with cycloheximide (CHX) decreased this half-life to 4 h. Moreover, inhibition of protein synthesis was associated with decreases in c-fms mRNA levels and a block in the induction of c-fms transcripts by TPA.	Tetradecanoylphorbol Acetate	38-41	colony stimulating factor 1 receptor	Homo sapiens	17-22
2523515-6	1989	The half-life of c-fms transcripts in TPA-induced HL-60 cells was found to be at least 6 h, while inhibition of protein synthesis with cycloheximide (CHX) decreased this half-life to 4 h. Moreover, inhibition of protein synthesis was associated with decreases in c-fms mRNA levels and a block in the induction of c-fms transcripts by TPA.	Tetradecanoylphorbol Acetate	38-41	colony stimulating factor 1 receptor	Homo sapiens	263-268
2523515-6	1989	The half-life of c-fms transcripts in TPA-induced HL-60 cells was found to be at least 6 h, while inhibition of protein synthesis with cycloheximide (CHX) decreased this half-life to 4 h. Moreover, inhibition of protein synthesis was associated with decreases in c-fms mRNA levels and a block in the induction of c-fms transcripts by TPA.	Tetradecanoylphorbol Acetate	38-41	colony stimulating factor 1 receptor	Homo sapiens	263-268
2523515-6	1989	The half-life of c-fms transcripts in TPA-induced HL-60 cells was found to be at least 6 h, while inhibition of protein synthesis with cycloheximide (CHX) decreased this half-life to 4 h. Moreover, inhibition of protein synthesis was associated with decreases in c-fms mRNA levels and a block in the induction of c-fms transcripts by TPA.	Tetradecanoylphorbol Acetate	334-337	colony stimulating factor 1 receptor	Homo sapiens	17-22
2523515-8	1989	In contrast to HL-60 cells, c-fms mRNA is constitutively expressed in resting human monocytes and is down-regulated by treatment of these cells with TPA.	Tetradecanoylphorbol Acetate	149-152	colony stimulating factor 1 receptor	Homo sapiens	28-33
2523515-9	1989	Run-on assays demonstrated that TPA-induced downregulation of c-fms mRNA levels in monocytes occurred at the posttranscriptional level.	Tetradecanoylphorbol Acetate	32-35	colony stimulating factor 1 receptor	Homo sapiens	62-67
2650613-4	1989	Intracellular pH (pHi) was increased by TPA treatment; however, while the alkalinization of K-562 cells was dependent on the presence of extracellular Na+, the response of U-937 cells was unaffected by the removal of this cation.	Tetradecanoylphorbol Acetate	40-43	glucose-6-phosphate isomerase	Homo sapiens	18-21
2650613-5	1989	In each cell type the protein kinase C (PKC) inhibitor H-7 largely attenuated the TPA induced increase of pHi.	Tetradecanoylphorbol Acetate	82-85	glucose-6-phosphate isomerase	Homo sapiens	106-109
2535694-6	1989	In contrast, other agents such as phorbol 12-myristate 13-acetate known to induce differentiation in this cell line do cause an increase in pHi.	Tetradecanoylphorbol Acetate	34-65	glucose-6-phosphate isomerase	Homo sapiens	140-143
2522048-1	1989	We have found that approximately 10%-15% of tonsil, but not peripheral blood, T cells express the CD23 antigen following activation with 12-O-tetradecanoylphorbol 13-acetate (TPA), phytohemagglutinin (PHA) or recombinant interleukin 4.	Tetradecanoylphorbol Acetate	137-173	Fc epsilon receptor II	Homo sapiens	98-102
2522048-1	1989	We have found that approximately 10%-15% of tonsil, but not peripheral blood, T cells express the CD23 antigen following activation with 12-O-tetradecanoylphorbol 13-acetate (TPA), phytohemagglutinin (PHA) or recombinant interleukin 4.	Tetradecanoylphorbol Acetate	175-178	Fc epsilon receptor II	Homo sapiens	98-102
2533112-4	1989	Phorbol 12-myristate 13-acetate is more efficacious than insulin in rising Fru-2,6-P2 content and less effective in the stimulation of glycolysis.	Tetradecanoylphorbol Acetate	0-31	zinc finger and BTB domain containing 22	Homo sapiens	75-78
2515163-5	1989	No definite correlation could be made between the inhibition of the ear oedema induced by arachidonic acid (AA), the inhibition of the epidermal ornithine-decarboxylase (ODC) activity induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), and the in-vitro activities of the compounds.	Tetradecanoylphorbol Acetate	195-231	ornithine decarboxylase 1	Homo sapiens	170-173
2515163-5	1989	No definite correlation could be made between the inhibition of the ear oedema induced by arachidonic acid (AA), the inhibition of the epidermal ornithine-decarboxylase (ODC) activity induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), and the in-vitro activities of the compounds.	Tetradecanoylphorbol Acetate	233-236	ornithine decarboxylase 1	Homo sapiens	170-173
2515163-7	1989	As inhibitors of TPA-induced ODC, all 3 compounds exhibited comparable activity.	Tetradecanoylphorbol Acetate	17-20	ornithine decarboxylase 1	Homo sapiens	29-32
2977423-2	1988	Although 12-O-tetradecanoylphorbol-13-acetate (TPA) was capable of replacing IL-1 as an activating stimulus under certain conditions, biologic studies indicated that TPA failed to synergize with Ti-CD3-dependent stimuli under conditions in which IL-1 was clearly active.	Tetradecanoylphorbol Acetate	47-50	interleukin 1 complex	Mus musculus	77-81
3056960-8	1988	Phorbol myristate acetate (PMA)-induced grranulocyte adhesion to HUVE was significantly inhibited by anti-Mo1a and anti-beta, but not by anti-LFA-1a or anti-p150.	Tetradecanoylphorbol Acetate	27-30	chromatin assembly factor 1 subunit A	Homo sapiens	157-161
2547991-0	1989	Loss of responsiveness of an AP1-related factor, PEBP1, to 12-O-tetradecanoylphorbol-13-acetate after transformation of NIH 3T3 cells by the Ha-ras oncogene.	Tetradecanoylphorbol Acetate	59-95	jun proto-oncogene	Mus musculus	29-32
2506075-1	1989	In two-dimensional tryptic phosphopeptide mapping, the beta-subunit of the insulin receptor phosphorylated by 12-O-tetradecanoylphorbol-13-acetate in rat hepatoma cells (H-35) was separated into one phosphothreonine-containing peptide and several phosphoserine-containing peptides.	Tetradecanoylphorbol Acetate	110-146	insulin receptor	Rattus norvegicus	75-91
2787874-7	1989	In conditioned media from LPS-PMA-stimulated macrophages, IL-1 levels were significantly greater than in media from unstimulated macrophages and peaked on Postsurgical Day 3.	Tetradecanoylphorbol Acetate	30-33	interleukin 1 complex	Mus musculus	58-62
2550296-8	1989	Phorbol 12-myristate 13-acetate (10(-7) M), dioctanoylglycerol (10(-4) M) and phospholipase C (100 mU/ml) also stimulated ACTH secretion in these cells by 4.2-, 2.4-, and 3.7-fold, respectively.	Tetradecanoylphorbol Acetate	0-31	pro-opiomelanocortin-alpha	Mus musculus	122-126
2550298-8	1989	The protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) inhibited the stimulatory effects of hCG (76%) and PGF2 alpha (62%) on cAMP and inositol phosphate accumulation, respectively.	Tetradecanoylphorbol Acetate	32-68	chorionic gonadotropin subunit beta 5	Homo sapiens	112-115
2550298-8	1989	The protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) inhibited the stimulatory effects of hCG (76%) and PGF2 alpha (62%) on cAMP and inositol phosphate accumulation, respectively.	Tetradecanoylphorbol Acetate	70-73	chorionic gonadotropin subunit beta 5	Homo sapiens	112-115
2677677-5	1989	When GM-CSF-deprived 32D clone 3 cells were exposed to GM-CSF or to TPA, four TIS mRNAs (TIS7, TIS8, TIS10, and TIS11) were rapidly and transiently induced.	Tetradecanoylphorbol Acetate	68-71	prostaglandin-endoperoxide synthase 2	Mus musculus	101-106
2677677-7	1989	Both GM-CSF and TPA also elicited rapid, transient expression of TIS8 and TIS11 mRNA in postmitotic human neutrophils.	Tetradecanoylphorbol Acetate	16-19	ZFP36 ring finger protein	Homo sapiens	74-79
2787934-3	1989	Exposure of human T cells and some mouse T cells to the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA), an activator of protein kinase C, caused the dissociation of p56lck and CD4.	Tetradecanoylphorbol Acetate	71-108	lymphocyte protein tyrosine kinase	Mus musculus	177-183
2787934-3	1989	Exposure of human T cells and some mouse T cells to the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA), an activator of protein kinase C, caused the dissociation of p56lck and CD4.	Tetradecanoylphorbol Acetate	110-113	lymphocyte protein tyrosine kinase	Mus musculus	177-183
2543699-6	1989	The addition of anti-CD28 to T cells stimulated with PMA plus calcium ionophore induced a 5- to 100-fold increase in IL-2 gene expression and secretion that was resistant to cyclosporine.	Tetradecanoylphorbol Acetate	53-56	CD28 molecule	Homo sapiens	21-25
2543699-7	1989	The CD28 signal was able to increase steady state IL-2 mRNA levels even in cells treated with maximally tolerated amounts of calcium ionophore and PMA.	Tetradecanoylphorbol Acetate	147-150	CD28 molecule	Homo sapiens	4-8
2543699-9	1989	The signal provided by CD28 is distinct from that of CD3 because although anti-CD28 plus PMA-induced proliferation is resistant to cyclosporine, anti-CD3 or anti-CD3 plus PMA-induced IL-2 expression is sensitive.	Tetradecanoylphorbol Acetate	89-92	CD28 molecule	Homo sapiens	23-27
2779549-7	1989	Oncostatin M mRNA of approximately 2 kilobase pairs was detected in phorbol 12-myristate 13-acetate-treated U937 cells and in activated human T cells.	Tetradecanoylphorbol Acetate	68-99	oncostatin M	Homo sapiens	0-12
2544106-9	1989	Incubation with phorbol myristate acetate decreased 125I-EGF binding in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	16-41	epidermal growth factor like 1	Rattus norvegicus	57-60
2785869-5	1989	Lipopolysaccharide (LPS)-triggered release of IL-1 and TNF was determined in culture supernatants of splenic MPs from phorbol ester-sensitive (SENCAR) and resistant (B6C3F1) mice following topical application of 8 micrograms of TPA twice in one week.	Tetradecanoylphorbol Acetate	228-231	interleukin 1 complex	Mus musculus	46-58
2722787-4	1989	Treating intact cells with the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), or with diacylglycerol also causes desensitization of the hCG response.	Tetradecanoylphorbol Acetate	47-84	chorionic gonadotropin subunit beta 5	Homo sapiens	150-153
2722787-4	1989	Treating intact cells with the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), or with diacylglycerol also causes desensitization of the hCG response.	Tetradecanoylphorbol Acetate	86-89	chorionic gonadotropin subunit beta 5	Homo sapiens	150-153
2495278-1	1989	In this study we report that pretreatment of human amniotic (WISH) cells with interferon gamma (IFN-gamma) in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in the down-modulation of epidermal growth factor (EGF) receptors with respect to both receptor number and affinity.	Tetradecanoylphorbol Acetate	126-162	NCK interacting protein with SH3 domain	Homo sapiens	61-65
2495278-1	1989	In this study we report that pretreatment of human amniotic (WISH) cells with interferon gamma (IFN-gamma) in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in the down-modulation of epidermal growth factor (EGF) receptors with respect to both receptor number and affinity.	Tetradecanoylphorbol Acetate	164-167	NCK interacting protein with SH3 domain	Homo sapiens	61-65
2565719-2	1989	The CD11c subunit antigen and mRNA are constitutively expressed in undifferentiated HL-60 promyelocytic leukemia cells, and levels increase markedly with differentiation along the monocyte/macrophage pathway using phorbol myristate acetate.	Tetradecanoylphorbol Acetate	214-239	integrin subunit alpha X	Homo sapiens	4-9
2469910-4	1989	Treatment of the TsF2 producing hybridoma with phorbol myristate acetate (PMA) causes an increase in the level of IL-2 receptor expression in this hybridoma and enhances the effects of IL-2 on the biosynthesis of TsF2.	Tetradecanoylphorbol Acetate	47-72	interleukin 2 receptor subunit beta	Homo sapiens	114-127
2469910-4	1989	Treatment of the TsF2 producing hybridoma with phorbol myristate acetate (PMA) causes an increase in the level of IL-2 receptor expression in this hybridoma and enhances the effects of IL-2 on the biosynthesis of TsF2.	Tetradecanoylphorbol Acetate	74-77	interleukin 2 receptor subunit beta	Homo sapiens	114-127
2844818-2	1988	Here, we show that treatment of choriocarcinoma cells with activators of protein kinase C, such as phorbol myristate acetate (PMA) and dioctanoylglycerol, increases accumulation of the mRNAs for both subunits of hCG by 3-4-fold.	Tetradecanoylphorbol Acetate	99-124	chorionic gonadotropin subunit beta 5	Homo sapiens	212-215
2844818-2	1988	Here, we show that treatment of choriocarcinoma cells with activators of protein kinase C, such as phorbol myristate acetate (PMA) and dioctanoylglycerol, increases accumulation of the mRNAs for both subunits of hCG by 3-4-fold.	Tetradecanoylphorbol Acetate	126-129	chorionic gonadotropin subunit beta 5	Homo sapiens	212-215
3139753-5	1988	TPA and A23187 synergistically induced both IL-2R and c-myc mRNA expression by the lpr Lyt-2- L3T4- T cells, as well as by normal T cells.	Tetradecanoylphorbol Acetate	0-3	CD8 antigen, alpha chain	Mus musculus	87-92
3141549-2	1988	Pretreatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) for 3 h significantly suppressed the rGH release induced by GRF, but not that by 8-bromo-cAMP 20 h later; this suppressive effect of TPA was concentration-dependent from 8 to 160 nmol/l, and complete suppression was observed after pretreatment with 80-160 nmol TPA/l.	Tetradecanoylphorbol Acetate	18-54	growth hormone releasing hormone	Rattus norvegicus	121-124
3141549-2	1988	Pretreatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) for 3 h significantly suppressed the rGH release induced by GRF, but not that by 8-bromo-cAMP 20 h later; this suppressive effect of TPA was concentration-dependent from 8 to 160 nmol/l, and complete suppression was observed after pretreatment with 80-160 nmol TPA/l.	Tetradecanoylphorbol Acetate	56-59	growth hormone releasing hormone	Rattus norvegicus	121-124
3141549-3	1988	Production of cAMP by pituitary cells stimulated with GRF was similarly attenuated in TPA-pretreated cells.	Tetradecanoylphorbol Acetate	86-89	growth hormone releasing hormone	Rattus norvegicus	54-57
3141549-4	1988	The rGH responsiveness to GRF of these cells was fully recovered on prolonged culture (40 h), suggesting that the inhibitory effect of TPA is reversible.	Tetradecanoylphorbol Acetate	135-138	growth hormone releasing hormone	Rattus norvegicus	26-29
3141549-5	1988	In contrast, pretreatment with GRF (5 nmol/l) resulted in suppression of the rGH response to subsequent exposure to GRF (5 nmol/l) or 8-bromo-cAMP (10 mmol/l), but not to TPA.	Tetradecanoylphorbol Acetate	171-174	growth hormone releasing hormone	Rattus norvegicus	31-34
3141549-5	1988	In contrast, pretreatment with GRF (5 nmol/l) resulted in suppression of the rGH response to subsequent exposure to GRF (5 nmol/l) or 8-bromo-cAMP (10 mmol/l), but not to TPA.	Tetradecanoylphorbol Acetate	171-174	growth hormone releasing hormone	Rattus norvegicus	116-119
3141549-6	1988	These observations suggest that pretreatment with TPA modifies the rGH response to GRF at steps before the formation of cAMP.	Tetradecanoylphorbol Acetate	50-53	growth hormone releasing hormone	Rattus norvegicus	83-86
2497279-3	1989	In this paper, we describe the production of BCAF by a human T cell tumor line T687 after phorbol myristate acetate (PMA) stimulation; this production can be potentiated by phytohemagglutinin (PHA).	Tetradecanoylphorbol Acetate	90-115	TNF superfamily member 13b	Homo sapiens	45-49
2497279-3	1989	In this paper, we describe the production of BCAF by a human T cell tumor line T687 after phorbol myristate acetate (PMA) stimulation; this production can be potentiated by phytohemagglutinin (PHA).	Tetradecanoylphorbol Acetate	117-120	TNF superfamily member 13b	Homo sapiens	45-49
2522003-0	1989	Expression of thromboxane A2 receptor in cultured human erythroleukemia cells and its induction by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	99-135	thromboxane A2 receptor	Homo sapiens	14-37
2494663-1	1989	We have investigated the biochemical basis for the activation of interleukin 2 receptor alpha-subunit (IL-2R alpha) gene expression in primary human T lymphocytes by a cytokine (tumor necrosis factor alpha), a T-cell mitogen (phorbol 12-myristate 13-acetate), and the transactivator protein (Tax) from the type I human T-cell leukemia virus.	Tetradecanoylphorbol Acetate	226-257	interleukin 2 receptor subunit alpha	Homo sapiens	103-114
2900008-1	1988	The phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) enhances the effects of TRH on phase II of prolactin secretion as well as on hormone synthesis at both low and high TPA receptor occupancy.	Tetradecanoylphorbol Acetate	18-55	thyrotropin releasing hormone	Rattus norvegicus	86-89
2542017-4	1989	Five of these sites are also recognized by the TPA-activated HeLa cell factors AP-1 and AP-3.	Tetradecanoylphorbol Acetate	47-50	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-92
2900008-1	1988	The phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) enhances the effects of TRH on phase II of prolactin secretion as well as on hormone synthesis at both low and high TPA receptor occupancy.	Tetradecanoylphorbol Acetate	57-60	thyrotropin releasing hormone	Rattus norvegicus	86-89
2900008-2	1988	Furthermore TPA, but not the biologically inactive substance 4 alpha-phorbol 12,13-didecanoate (4 alpha-PDD), stimulates the particulate bound adenylate cyclase with a time course paralleling that of TRH activation.	Tetradecanoylphorbol Acetate	12-15	thyrotropin releasing hormone	Rattus norvegicus	200-203
2925687-4	1989	While TPA and epidermal growth factor treatment of keratinocyte cultures deprived of growth factors both induced TGF-alpha mRNA expression, maximum induction by TPA is 5-fold greater than epidermal growth factor.	Tetradecanoylphorbol Acetate	6-9	transforming growth factor alpha	Homo sapiens	113-122
2925687-6	1989	Under these experimental conditions, TPA increased levels of secreted TGF-alpha protein by 20-fold at 24 h. Concentration dependence and kinetic studies of TGF-alpha expression showed that TPA (greater than or equal to 1 ng/ml) induced accumulation of TGF-alpha mRNA with an optimum concentration of 10 ng/ml.	Tetradecanoylphorbol Acetate	37-40	transforming growth factor alpha	Homo sapiens	70-79
3165309-1	1988	Upon stimulation with a phorbol ester and known tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), the human erythroleukemia K562 cell line, a standard target for human natural killer (NK) cells, shows a significant reduction in expression of transferrin receptors (TfR) and becomes resistant to NK-mediated cytolysis.	Tetradecanoylphorbol Acetate	103-106	transferrin receptor	Homo sapiens	253-274
2492047-6	1989	Ag-mediated activation of cytolysis, lymphokine production, and exocytosis could be mimicked by mAb against the TCR/CD3 complex, or by stimulation with the combination of PMA + calcium ionophore, which appear to bypass the TCR (neither PMA nor calcium ionophore alone induced these functions efficiently in our CD8+ CTL clones).	Tetradecanoylphorbol Acetate	171-174	CD3 antigen, epsilon polypeptide	Mus musculus	116-119
3165309-1	1988	Upon stimulation with a phorbol ester and known tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), the human erythroleukemia K562 cell line, a standard target for human natural killer (NK) cells, shows a significant reduction in expression of transferrin receptors (TfR) and becomes resistant to NK-mediated cytolysis.	Tetradecanoylphorbol Acetate	103-106	transferrin receptor	Homo sapiens	276-279
3165309-6	1988	Based on the properties of phorbol ester induction, it is possible that the NK-target molecule is down-regulated in response to phorbol ester induction in a similar, if not identical manner to that of the TfR; thus, rendering NK-sensitive cells resistant to NK killing, after TPA exposure.	Tetradecanoylphorbol Acetate	276-279	transferrin receptor	Homo sapiens	205-208
3261728-1	1988	A selected clone from an IL-2-dependent human T-cell line was persistently propagated in the presence of phorbol esters with the ability to activate protein kinase C (PKC), such as 12-O-tetradecanoylphorbol-13-acetate (TPA) or phorbol-12,13-dibutylate (PDBu).	Tetradecanoylphorbol Acetate	181-217	protein kinase C beta	Homo sapiens	167-170
3261728-1	1988	A selected clone from an IL-2-dependent human T-cell line was persistently propagated in the presence of phorbol esters with the ability to activate protein kinase C (PKC), such as 12-O-tetradecanoylphorbol-13-acetate (TPA) or phorbol-12,13-dibutylate (PDBu).	Tetradecanoylphorbol Acetate	219-222	protein kinase C beta	Homo sapiens	167-170
2925687-6	1989	Under these experimental conditions, TPA increased levels of secreted TGF-alpha protein by 20-fold at 24 h. Concentration dependence and kinetic studies of TGF-alpha expression showed that TPA (greater than or equal to 1 ng/ml) induced accumulation of TGF-alpha mRNA with an optimum concentration of 10 ng/ml.	Tetradecanoylphorbol Acetate	37-40	transforming growth factor alpha	Homo sapiens	156-165
2925687-6	1989	Under these experimental conditions, TPA increased levels of secreted TGF-alpha protein by 20-fold at 24 h. Concentration dependence and kinetic studies of TGF-alpha expression showed that TPA (greater than or equal to 1 ng/ml) induced accumulation of TGF-alpha mRNA with an optimum concentration of 10 ng/ml.	Tetradecanoylphorbol Acetate	37-40	transforming growth factor alpha	Homo sapiens	156-165
2925687-6	1989	Under these experimental conditions, TPA increased levels of secreted TGF-alpha protein by 20-fold at 24 h. Concentration dependence and kinetic studies of TGF-alpha expression showed that TPA (greater than or equal to 1 ng/ml) induced accumulation of TGF-alpha mRNA with an optimum concentration of 10 ng/ml.	Tetradecanoylphorbol Acetate	189-192	transforming growth factor alpha	Homo sapiens	70-79
2925687-6	1989	Under these experimental conditions, TPA increased levels of secreted TGF-alpha protein by 20-fold at 24 h. Concentration dependence and kinetic studies of TGF-alpha expression showed that TPA (greater than or equal to 1 ng/ml) induced accumulation of TGF-alpha mRNA with an optimum concentration of 10 ng/ml.	Tetradecanoylphorbol Acetate	189-192	transforming growth factor alpha	Homo sapiens	156-165
2925687-6	1989	Under these experimental conditions, TPA increased levels of secreted TGF-alpha protein by 20-fold at 24 h. Concentration dependence and kinetic studies of TGF-alpha expression showed that TPA (greater than or equal to 1 ng/ml) induced accumulation of TGF-alpha mRNA with an optimum concentration of 10 ng/ml.	Tetradecanoylphorbol Acetate	189-192	transforming growth factor alpha	Homo sapiens	156-165
2925687-7	1989	TGF-alpha mRNA expression increased within 1 h following TPA treatment (10 ng/ml) and peaked at 5 h. At 24 h, TPA-treated cultures still expressed elevated levels of TGF-alpha mRNA (1.7-fold).	Tetradecanoylphorbol Acetate	57-60	transforming growth factor alpha	Homo sapiens	0-9
2925687-7	1989	TGF-alpha mRNA expression increased within 1 h following TPA treatment (10 ng/ml) and peaked at 5 h. At 24 h, TPA-treated cultures still expressed elevated levels of TGF-alpha mRNA (1.7-fold).	Tetradecanoylphorbol Acetate	110-113	transforming growth factor alpha	Homo sapiens	0-9
2925687-7	1989	TGF-alpha mRNA expression increased within 1 h following TPA treatment (10 ng/ml) and peaked at 5 h. At 24 h, TPA-treated cultures still expressed elevated levels of TGF-alpha mRNA (1.7-fold).	Tetradecanoylphorbol Acetate	110-113	transforming growth factor alpha	Homo sapiens	166-175
3261728-6	1988	Although activity of PKC was down-regulated, messenger ribonucleic acid (mRNA) of the PKC beta-gene was detected in TPA-Mat cells cultured with PDBu.	Tetradecanoylphorbol Acetate	116-119	protein kinase C beta	Homo sapiens	86-94
3261728-7	1988	Furthermore, the growth of TPA-Mat cells was stimulated not only by phorbol esters but also by nonphorbol ester tumor promoters with the ability to activate PKC.	Tetradecanoylphorbol Acetate	27-30	protein kinase C beta	Homo sapiens	157-160
3261375-2	1988	The current studies show that pretreatment of rat pulmonary artery endothelial cells with tumor necrosis factor increases in a time- and dose-dependent manner their sensitivity to killing by neutrophils stimulated with phorbol myristate acetate or C5a.	Tetradecanoylphorbol Acetate	219-244	tumor necrosis factor-like	Rattus norvegicus	90-111
2523864-1	1989	Recombinant IL-2 (rIL-2) and IL-4 (rIL-4) promote proliferation of human CD4+ T cells activated in the presence of PHA, TPA or OKT-3 monoclonal antibody (MAb), whereas the production of interferon-gamma (IFN) can be induced only by rIL-2.	Tetradecanoylphorbol Acetate	120-123	interleukin 4	Rattus norvegicus	35-40
2925687-9	1989	Prolonged pretreatment (24 h) of keratinocyte cultures with TPA caused marked desensitization of TGF-alpha mRNA expression to repeated stimulation by phorbol ester.	Tetradecanoylphorbol Acetate	60-63	transforming growth factor alpha	Homo sapiens	97-106
2535800-7	1989	The Ca2+ channel blocker verapamil (100 microM) significantly inhibited the GRF response to both forskolin and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	111-142	growth hormone releasing hormone	Rattus norvegicus	76-79
2925687-11	1989	The rate of TGF-alpha mRNA accumulation peaked and declined earlier for 1,2-sn-dioctanoylglycerol compared to TPA.	Tetradecanoylphorbol Acetate	110-113	transforming growth factor alpha	Homo sapiens	12-21
2925687-15	1989	Actinomycin D abrogated transcriptional activation of TGF-alpha mRNA by TPA.	Tetradecanoylphorbol Acetate	72-75	transforming growth factor alpha	Homo sapiens	54-63
2538715-7	1989	The expression of each of these genes, including d-2 (NGF I-A), was also increased by fibroblast growth factor, epidermal growth factor (EGF), phorbol myristate acetate, and in some cases insulin, showing that the regulation of these genes is not unique to NGF.	Tetradecanoylphorbol Acetate	143-168	nerve growth factor	Rattus norvegicus	54-57
2496956-3	1989	We used the phorbol ester/lipopolysaccharide (PMA + LPS) co-induction of IL-1 mRNA and CD13 expression in U937 cells to demonstrate the specificity of the technique.	Tetradecanoylphorbol Acetate	46-49	alanyl aminopeptidase, membrane	Homo sapiens	87-91
2785706-3	1989	In the presence of TPA or antibodies to CDw40, the proportions of CD43+ cells drastically increased.	Tetradecanoylphorbol Acetate	19-22	CD40 molecule	Homo sapiens	40-45
3053708-8	1988	TPA caused rapid and complete translocation of cytosolic protein kinase C to the particulate fraction of pituitary cells, followed by a progressive decrease in total enzyme content to approximately 10% after 6 h. Partial recovery of the cytosolic enzyme (to 20%) occurred after washing and reincubation for 15 h. Such kinase C-depleted cells showed prominent, dose-dependent reductions in the actions of GnRH and TPA on LH release and synthesis in both normal and Ca2+-deficient media.	Tetradecanoylphorbol Acetate	0-3	gonadotropin releasing hormone 1	Homo sapiens	404-408
2914915-2	1989	Following treatment of reticulocytes with phorbol 12-myristate 13-acetate (PMA) for 30 min, stimulation of phosphorylation of both the p25 and p220 subunits was observed (2.5-5-fold).	Tetradecanoylphorbol Acetate	42-73	eukaryotic translation initiation factor 4 gamma 1	Oryctolagus cuniculus	143-147
2914915-2	1989	Following treatment of reticulocytes with phorbol 12-myristate 13-acetate (PMA) for 30 min, stimulation of phosphorylation of both the p25 and p220 subunits was observed (2.5-5-fold).	Tetradecanoylphorbol Acetate	75-78	eukaryotic translation initiation factor 4 gamma 1	Oryctolagus cuniculus	143-147
3048655-5	1988	TPA treatment of HT-29 G+ or G- cells induced early morphological and cytoskeletal alterations: the cells rounded up and lost their stress fibers with the associated caldesmon, alpha-actinin, and vinculin.	Tetradecanoylphorbol Acetate	0-3	vinculin	Homo sapiens	196-204
2522880-4	1989	In the presence of the tumor promoter phorbol 12-myristate 13-acetate IL 1 augments IL 2 secretion and IL 2R expression of EL4 5D3 but not of EL4 D6/76 cells.	Tetradecanoylphorbol Acetate	38-69	interleukin 1 complex	Mus musculus	70-74
2464075-9	1988	The phorbol ester 12-O-tetradecanoyl phorbol acetate was found to reduce intracellular MBP RNA levels.	Tetradecanoylphorbol Acetate	18-52	myelin basic protein	Homo sapiens	87-90
2643508-2	1989	Treatment of dispersed ovine pituitary cells with the PKC activator phorbol 12-myristate-13-acetate (PMA) for 6 h at a dose of 10 nM stimulated the release of 5- to 10-fold more LH than did GnRH at the same dose.	Tetradecanoylphorbol Acetate	68-99	gonadotropin releasing hormone 1	Homo sapiens	190-194
2643508-2	1989	Treatment of dispersed ovine pituitary cells with the PKC activator phorbol 12-myristate-13-acetate (PMA) for 6 h at a dose of 10 nM stimulated the release of 5- to 10-fold more LH than did GnRH at the same dose.	Tetradecanoylphorbol Acetate	101-104	gonadotropin releasing hormone 1	Homo sapiens	190-194
28305429-8	1988	This corresponds to previous experiments which have shown that treatment of ectoderm with phorbol myristate acetate, an activator of protein kinase C and protein kinase C related enzymes, initiates neural differentiation.	Tetradecanoylphorbol Acetate	90-115	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	133-147
2465187-3	1989	Either 10(-9) M EGF or 100 ng/ml TPA stimulated the accumulation of both EGF receptor and TGF-alpha mRNA and staurosporine (50 nM) completely abolished these mRNA accumulations.	Tetradecanoylphorbol Acetate	33-36	transforming growth factor alpha	Homo sapiens	90-99
2466532-5	1989	Phorbol ester (PMA) did not alter SP content but significantly raised CGRP content by 40% in NGF supplemented cultures (P less than 0.001).	Tetradecanoylphorbol Acetate	15-18	calcitonin-related polypeptide alpha	Rattus norvegicus	70-74
2535800-6	1989	In nonpretreated cultures, forskolin (1-100 microM) and the protein kinase C activator phorbol 12-myristate 13-acetate (10 nM-1 microM), stimulated basal GRF release in a dose-dependent fashion.	Tetradecanoylphorbol Acetate	87-118	growth hormone releasing hormone	Rattus norvegicus	154-157
2522048-6	1989	Similarly, SN from a CD23+ L cell transfectant augments the proliferative response of tonsil T cells to both TPA and PHA.	Tetradecanoylphorbol Acetate	109-112	Fc epsilon receptor II	Homo sapiens	21-25
28305429-8	1988	This corresponds to previous experiments which have shown that treatment of ectoderm with phorbol myristate acetate, an activator of protein kinase C and protein kinase C related enzymes, initiates neural differentiation.	Tetradecanoylphorbol Acetate	90-115	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	154-168
2522048-7	1989	The CD23 molecule expressed by TPA-driven T cell blasts appears identical in size to the 45-kDa glycoprotein present on EBVLCL and activated B cells.	Tetradecanoylphorbol Acetate	31-34	Fc epsilon receptor II	Homo sapiens	4-8
2458349-8	1988	When cells were incubated continuously with TRH, there was a recovery of 125I-EGF binding after 24 h. Incubation with the protein kinase C activating phorbol ester TPA caused an immediate (less than 10 min) profound (greater than 85%) decrease in 125I-EGF binding followed by partial recovery at 24 h. Maximally effective doses of TRH and TPA decreased EGF receptor affinity with half-times of 3 min.	Tetradecanoylphorbol Acetate	164-167	thyrotropin releasing hormone	Rattus norvegicus	44-47
2522048-9	1989	The results presented here demonstrate that CD23 is expressed on activated tonsil, but not peripheral blood T cells and plays a role, via the binding of CD23 mAb and CD23+ material, present in EBVLCL and CD23+ transfectant SN, in the regulation of T cell proliferation in response to mitogens such as PHA and TPA.	Tetradecanoylphorbol Acetate	309-312	Fc epsilon receptor II	Homo sapiens	44-48
2522048-9	1989	The results presented here demonstrate that CD23 is expressed on activated tonsil, but not peripheral blood T cells and plays a role, via the binding of CD23 mAb and CD23+ material, present in EBVLCL and CD23+ transfectant SN, in the regulation of T cell proliferation in response to mitogens such as PHA and TPA.	Tetradecanoylphorbol Acetate	309-312	Fc epsilon receptor II	Homo sapiens	153-157
2522048-9	1989	The results presented here demonstrate that CD23 is expressed on activated tonsil, but not peripheral blood T cells and plays a role, via the binding of CD23 mAb and CD23+ material, present in EBVLCL and CD23+ transfectant SN, in the regulation of T cell proliferation in response to mitogens such as PHA and TPA.	Tetradecanoylphorbol Acetate	309-312	Fc epsilon receptor II	Homo sapiens	153-157
2522048-9	1989	The results presented here demonstrate that CD23 is expressed on activated tonsil, but not peripheral blood T cells and plays a role, via the binding of CD23 mAb and CD23+ material, present in EBVLCL and CD23+ transfectant SN, in the regulation of T cell proliferation in response to mitogens such as PHA and TPA.	Tetradecanoylphorbol Acetate	309-312	Fc epsilon receptor II	Homo sapiens	153-157
2458349-8	1988	When cells were incubated continuously with TRH, there was a recovery of 125I-EGF binding after 24 h. Incubation with the protein kinase C activating phorbol ester TPA caused an immediate (less than 10 min) profound (greater than 85%) decrease in 125I-EGF binding followed by partial recovery at 24 h. Maximally effective doses of TRH and TPA decreased EGF receptor affinity with half-times of 3 min.	Tetradecanoylphorbol Acetate	164-167	epidermal growth factor like 1	Rattus norvegicus	78-81
2458349-8	1988	When cells were incubated continuously with TRH, there was a recovery of 125I-EGF binding after 24 h. Incubation with the protein kinase C activating phorbol ester TPA caused an immediate (less than 10 min) profound (greater than 85%) decrease in 125I-EGF binding followed by partial recovery at 24 h. Maximally effective doses of TRH and TPA decreased EGF receptor affinity with half-times of 3 min.	Tetradecanoylphorbol Acetate	164-167	epidermal growth factor like 1	Rattus norvegicus	252-255
2458349-8	1988	When cells were incubated continuously with TRH, there was a recovery of 125I-EGF binding after 24 h. Incubation with the protein kinase C activating phorbol ester TPA caused an immediate (less than 10 min) profound (greater than 85%) decrease in 125I-EGF binding followed by partial recovery at 24 h. Maximally effective doses of TRH and TPA decreased EGF receptor affinity with half-times of 3 min.	Tetradecanoylphorbol Acetate	164-167	thyrotropin releasing hormone	Rattus norvegicus	331-334
2458349-8	1988	When cells were incubated continuously with TRH, there was a recovery of 125I-EGF binding after 24 h. Incubation with the protein kinase C activating phorbol ester TPA caused an immediate (less than 10 min) profound (greater than 85%) decrease in 125I-EGF binding followed by partial recovery at 24 h. Maximally effective doses of TRH and TPA decreased EGF receptor affinity with half-times of 3 min.	Tetradecanoylphorbol Acetate	164-167	epidermal growth factor like 1	Rattus norvegicus	252-255
2458349-8	1988	When cells were incubated continuously with TRH, there was a recovery of 125I-EGF binding after 24 h. Incubation with the protein kinase C activating phorbol ester TPA caused an immediate (less than 10 min) profound (greater than 85%) decrease in 125I-EGF binding followed by partial recovery at 24 h. Maximally effective doses of TRH and TPA decreased EGF receptor affinity with half-times of 3 min.	Tetradecanoylphorbol Acetate	339-342	thyrotropin releasing hormone	Rattus norvegicus	44-47
2478466-6	1989	First, the effects of cAMP on MBP phosphorylation are reversed with exogenous TPA; and second, cAMP inhibits the incorporation of 1-[14C]arachidonate into DAG and specifically inhibits the turnover (as judged by 32PO4 3-incorporation) of phosphatidylinositol.	Tetradecanoylphorbol Acetate	78-81	myelin basic protein	Homo sapiens	30-33
2458349-8	1988	When cells were incubated continuously with TRH, there was a recovery of 125I-EGF binding after 24 h. Incubation with the protein kinase C activating phorbol ester TPA caused an immediate (less than 10 min) profound (greater than 85%) decrease in 125I-EGF binding followed by partial recovery at 24 h. Maximally effective doses of TRH and TPA decreased EGF receptor affinity with half-times of 3 min.	Tetradecanoylphorbol Acetate	339-342	epidermal growth factor like 1	Rattus norvegicus	78-81
2458349-10	1988	GH4C1 cells were incubated with 500 nM TPA for 24 h in order to down-regulate protein kinase C. Protein kinase C depletion was confirmed by immunoblots and the effects of TRH and TPA on 125I-EGF binding were tested.	Tetradecanoylphorbol Acetate	39-42	epidermal growth factor like 1	Rattus norvegicus	191-194
3139753-1	1988	We have previously shown that Lyt-2- L3T4- T cells from the lymph nodes of MRL/lpr/lpr mice could respond to 12-O-tetradecanoylphorbol-2-acetate (TPA) and A23187 by proliferation, IL-2 secretion, and IL-2R (IL-2R) expression.	Tetradecanoylphorbol Acetate	146-149	CD8 antigen, alpha chain	Mus musculus	30-35
2547280-10	1989	In contrast, the phorbol ester, phorbol 12-myristate 13-acetate, produced a biphasic change in the level of choline acetyltransferase activity; with lower doses stimulating and higher doses inhibiting the enzyme activity.	Tetradecanoylphorbol Acetate	32-63	choline acetyltransferase	Mus musculus	108-133
2841099-2	1988	The PKC activator tetradecanoyl-phorbol acetate (TPA) alone induced a time- and concentration-dependent stimulation of the incorporation of [3H]thymidine into the DNA of quiescent FRTL5 cells, an effect anteceded by an increase in the levels of the mRNAs of the proto-oncogene c-myc and associated with a stimulation of cell replication.	Tetradecanoylphorbol Acetate	18-47	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	262-282
2841099-2	1988	The PKC activator tetradecanoyl-phorbol acetate (TPA) alone induced a time- and concentration-dependent stimulation of the incorporation of [3H]thymidine into the DNA of quiescent FRTL5 cells, an effect anteceded by an increase in the levels of the mRNAs of the proto-oncogene c-myc and associated with a stimulation of cell replication.	Tetradecanoylphorbol Acetate	49-52	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	262-282
3264213-6	1988	In addition, inhibition of PKC by the kinase inhibitor, H7, led to the inhibition of EA1 expression induced by TPA and synthetic diacylglycerols.	Tetradecanoylphorbol Acetate	111-114	CD69 molecule	Homo sapiens	85-88
2457516-2	1988	Cells treated for 4 days with the maturation inducer phorbol 12-myristate 13-acetate, were found to increase both the number of cells binding protein HC (76% higher than for untreated cells) and the expression of protein HC receptors.	Tetradecanoylphorbol Acetate	53-84	alpha-1-microglobulin/bikunin precursor	Homo sapiens	142-152
3264362-5	1988	Following activation in vitro with a series of different stimulatory agents including BCGF, phorbol myristate acetate, and anti-human IgM antibody, cultured HCs increased their capability to shed the IL-2R molecules.	Tetradecanoylphorbol Acetate	92-117	interleukin 2 receptor subunit alpha	Homo sapiens	200-205
2457516-2	1988	Cells treated for 4 days with the maturation inducer phorbol 12-myristate 13-acetate, were found to increase both the number of cells binding protein HC (76% higher than for untreated cells) and the expression of protein HC receptors.	Tetradecanoylphorbol Acetate	53-84	alpha-1-microglobulin/bikunin precursor	Homo sapiens	213-223
3265113-3	1988	Levels of hCS-1 gene mRNA and hCS release were increased by thyroid hormone, dexamethasone, a cyclic adenosine monophosphate (cAMP) analogue (8-bromo-cAMP), and phorbol ester, phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	176-207	holocarboxylase synthetase	Homo sapiens	10-13
3265113-3	1988	Levels of hCS-1 gene mRNA and hCS release were increased by thyroid hormone, dexamethasone, a cyclic adenosine monophosphate (cAMP) analogue (8-bromo-cAMP), and phorbol ester, phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	209-212	holocarboxylase synthetase	Homo sapiens	10-13
3165309-1	1988	Upon stimulation with a phorbol ester and known tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), the human erythroleukemia K562 cell line, a standard target for human natural killer (NK) cells, shows a significant reduction in expression of transferrin receptors (TfR) and becomes resistant to NK-mediated cytolysis.	Tetradecanoylphorbol Acetate	65-101	transferrin receptor	Homo sapiens	253-274
2838469-4	1988	The induction of TcR-alpha and -delta mRNA by 12-O-tetradecanoylphorbol-13-acetate occurred at the transcriptional level only whereas cAMP treatment decreased both TcR-alpha gene transcription and the stability of its mRNA.	Tetradecanoylphorbol Acetate	46-82	T cell receptor alpha constant	Homo sapiens	17-26
3165309-1	1988	Upon stimulation with a phorbol ester and known tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), the human erythroleukemia K562 cell line, a standard target for human natural killer (NK) cells, shows a significant reduction in expression of transferrin receptors (TfR) and becomes resistant to NK-mediated cytolysis.	Tetradecanoylphorbol Acetate	65-101	transferrin receptor	Homo sapiens	276-279
3261728-8	1988	These observations suggest that the sustained activation of PKC by the phorbol esters could induce continuous growth of the IL-2-dependent TPA-Mat cells.	Tetradecanoylphorbol Acetate	139-142	protein kinase C beta	Homo sapiens	60-63
3255363-2	1988	Changes in insulin receptor number, affinity and mRNA levels were observed when HL60 cells were induced to differentiate with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or dimethylsulphoxide (DMSO).	Tetradecanoylphorbol Acetate	126-163	insulin receptor	Homo sapiens	11-27
3130982-1	1988	In response to phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA), HL-60 cells differentiate to macrophage-like cells and exhibit the ability to phosphorylate vinculin in vitro.	Tetradecanoylphorbol Acetate	38-74	vinculin	Homo sapiens	174-182
3255363-2	1988	Changes in insulin receptor number, affinity and mRNA levels were observed when HL60 cells were induced to differentiate with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or dimethylsulphoxide (DMSO).	Tetradecanoylphorbol Acetate	165-168	insulin receptor	Homo sapiens	11-27
3255363-3	1988	Total and high-affinity insulin receptor numbers decreased following treatment of HL60 cells with DMSO, whereas total insulin receptor number increased and high-affinity receptor number decreased in cells treated with TPA.	Tetradecanoylphorbol Acetate	218-221	insulin receptor	Homo sapiens	118-134
2906508-4	1988	Ionomycin in combination with the phorbol ester, TPA, mimics the TRH-elicited PRL release, and SRIH partly inhibited this effect.	Tetradecanoylphorbol Acetate	49-52	thyrotropin releasing hormone	Rattus norvegicus	65-68
3130982-1	1988	In response to phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA), HL-60 cells differentiate to macrophage-like cells and exhibit the ability to phosphorylate vinculin in vitro.	Tetradecanoylphorbol Acetate	76-79	vinculin	Homo sapiens	174-182
3130982-8	1988	Coincident with these changes after TPA treatment was a reduction in Ca2+ and phospholipid-independent phosphorylation of vinculin in vitro in extracts from HL-60/ADR cells, whereas HL-60 cells exhibited an elevation of this phosphoprotein.	Tetradecanoylphorbol Acetate	36-39	vinculin	Homo sapiens	122-130
3130982-9	1988	The phosphorylation of vinculin in TPA-treated HL-60 cells or untreated HL-60/ADR cells was blocked by antibodies to protein kinase C.	Tetradecanoylphorbol Acetate	35-38	vinculin	Homo sapiens	23-31
2455575-1	1988	The effect of differentiation induction by a tumor-promoting phorbol diester, 12-O-tetradecanoylphorbol-13-acetate (TPA) on a clonal human megakaryoblastic cell line, MEG-O1s, was investigated, and a prominent response was demonstrated.	Tetradecanoylphorbol Acetate	78-114	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	167-170
3281943-8	1988	12-O-tetradecanoyl phorbol 13-acetate (TPA) also induced beta-actin mRNA, decreased angiotensinogen mRNA, and caused an increase in [3H]methyl thymidine incorporation.	Tetradecanoylphorbol Acetate	0-37	actin, beta	Rattus norvegicus	57-67
2455575-10	1988	beta-TG was also observed in some cytoplasmic granules of TPA-treated cells.	Tetradecanoylphorbol Acetate	58-61	pro-platelet basic protein	Homo sapiens	0-7
2455575-11	1988	TPA remarkably increased the secretion of beta-TG into the culture medium of MEG-01s.	Tetradecanoylphorbol Acetate	0-3	pro-platelet basic protein	Homo sapiens	42-49
2455575-11	1988	TPA remarkably increased the secretion of beta-TG into the culture medium of MEG-01s.	Tetradecanoylphorbol Acetate	0-3	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	77-80
2455575-14	1988	These results indicate that phorbol diester, TPA, can bring about differentiation and maturation of a human megakaryoblastic cell line (MEG-01s) and that MEG-01s cells will provide a useful model for studying megakaryocytic differentiation and numerous megakaryocyte-platelet-specific proteins.	Tetradecanoylphorbol Acetate	45-48	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	136-139
2852964-8	1988	However, at a maximal dose of human chorionic gonadotropin (hCG), PMA inhibited steroid synthesis at 1 and 2 h but had no significant effect at 3 h. Conversely, PMA had an additive effect on cAMP induced steroidogenesis.	Tetradecanoylphorbol Acetate	66-69	hypertrichosis 2 (generalised, congenital)	Homo sapiens	60-63
2852964-8	1988	However, at a maximal dose of human chorionic gonadotropin (hCG), PMA inhibited steroid synthesis at 1 and 2 h but had no significant effect at 3 h. Conversely, PMA had an additive effect on cAMP induced steroidogenesis.	Tetradecanoylphorbol Acetate	161-164	hypertrichosis 2 (generalised, congenital)	Homo sapiens	60-63
3281943-8	1988	12-O-tetradecanoyl phorbol 13-acetate (TPA) also induced beta-actin mRNA, decreased angiotensinogen mRNA, and caused an increase in [3H]methyl thymidine incorporation.	Tetradecanoylphorbol Acetate	39-42	actin, beta	Rattus norvegicus	57-67
2843714-4	1988	Thereafter, O2- release by these cells in response to phorbol myristate acetate (PMA) was determined by cytochrome c reduction.	Tetradecanoylphorbol Acetate	54-79	cytochrome c	Oryctolagus cuniculus	104-116
2843714-4	1988	Thereafter, O2- release by these cells in response to phorbol myristate acetate (PMA) was determined by cytochrome c reduction.	Tetradecanoylphorbol Acetate	81-84	cytochrome c	Oryctolagus cuniculus	104-116
3355171-0	1988	Involvement of protein kinase C in the transcriptional regulation of ornithine decarboxylase gene expression by 12-O-tetradecanoylphorbol-13-acetate in T24 human bladder carcinoma cells.	Tetradecanoylphorbol Acetate	112-148	ornithine decarboxylase 1	Homo sapiens	69-92
2457172-0	1988	Induction of proto-oncogene JUN/AP-1 by serum and TPA.	Tetradecanoylphorbol Acetate	50-53	jun proto-oncogene	Mus musculus	32-36
2457172-7	1988	We report that mouse c-jun gene transcription is rapidly induced by serum and phorbol-ester 12-o-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	131-134	jun proto-oncogene	Mus musculus	21-26
3383778-8	1988	Phorbol myristate acetate (PMA) enhanced mitogenesis stimulated by PRL alone and in the presence of either stimulatory or inhibitory doses of IAP, but PMA did not block IAP inhibition.	Tetradecanoylphorbol Acetate	0-25	Cd47 molecule	Rattus norvegicus	142-145
3383778-8	1988	Phorbol myristate acetate (PMA) enhanced mitogenesis stimulated by PRL alone and in the presence of either stimulatory or inhibitory doses of IAP, but PMA did not block IAP inhibition.	Tetradecanoylphorbol Acetate	27-30	Cd47 molecule	Rattus norvegicus	142-145
3355171-1	1988	We have analyzed the molecular mechanisms involved in ornithine decarboxylase (ODC) induction by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in T24 cells, an easily manipulable human epithelial cell line.	Tetradecanoylphorbol Acetate	116-152	ornithine decarboxylase 1	Homo sapiens	54-77
2835990-8	1988	Furthermore, the findings that increased intracellular cAMP inhibits PMA- or OAG-induced p47 phosphorylation in excess of that due solely to CP/CPK, and that cAMP significantly potentiates the effects of ADP removal and inhibition of cyclooxygenase in blocking p47 phosphorylation suggest that cAMP also exerts non-ADP-mediated inhibitory effects on PKC in intact platelets.	Tetradecanoylphorbol Acetate	69-72	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	144-147
2455658-2	1988	12-O-Tetradecanoyl phorbol-13-acetate (PMA), butyrate, interferon, retinoic acid and 1,25-dihydroxyvitamin D3 all increased pHi.	Tetradecanoylphorbol Acetate	0-37	glucose-6-phosphate isomerase	Homo sapiens	124-127
2455658-2	1988	12-O-Tetradecanoyl phorbol-13-acetate (PMA), butyrate, interferon, retinoic acid and 1,25-dihydroxyvitamin D3 all increased pHi.	Tetradecanoylphorbol Acetate	39-42	glucose-6-phosphate isomerase	Homo sapiens	124-127
3355171-1	1988	We have analyzed the molecular mechanisms involved in ornithine decarboxylase (ODC) induction by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in T24 cells, an easily manipulable human epithelial cell line.	Tetradecanoylphorbol Acetate	116-152	ornithine decarboxylase 1	Homo sapiens	79-82
3355171-1	1988	We have analyzed the molecular mechanisms involved in ornithine decarboxylase (ODC) induction by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in T24 cells, an easily manipulable human epithelial cell line.	Tetradecanoylphorbol Acetate	154-157	ornithine decarboxylase 1	Homo sapiens	54-77
3355171-1	1988	We have analyzed the molecular mechanisms involved in ornithine decarboxylase (ODC) induction by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in T24 cells, an easily manipulable human epithelial cell line.	Tetradecanoylphorbol Acetate	154-157	ornithine decarboxylase 1	Homo sapiens	79-82
3355171-2	1988	The addition of as low as 10(-9)M TPA to T24 cells, cultured in a serum-free medium, resulted in ODC induction, with peak ODC activity occurring at about 6 h after TPA treatment.	Tetradecanoylphorbol Acetate	34-37	ornithine decarboxylase 1	Homo sapiens	97-100
3132714-1	1988	Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells.	Tetradecanoylphorbol Acetate	230-261	interleukin 2 receptor subunit alpha	Homo sapiens	81-92
3132714-1	1988	Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells.	Tetradecanoylphorbol Acetate	230-261	interleukin 2 receptor subunit alpha	Homo sapiens	106-110
3355171-2	1988	The addition of as low as 10(-9)M TPA to T24 cells, cultured in a serum-free medium, resulted in ODC induction, with peak ODC activity occurring at about 6 h after TPA treatment.	Tetradecanoylphorbol Acetate	34-37	ornithine decarboxylase 1	Homo sapiens	122-125
3132714-1	1988	Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells.	Tetradecanoylphorbol Acetate	230-261	interleukin 2 receptor subunit alpha	Homo sapiens	133-138
3355171-3	1988	The induction of ODC activity correlates with the steady-state levels of ODC mRNA increased by TPA in T24 cells.	Tetradecanoylphorbol Acetate	95-98	ornithine decarboxylase 1	Homo sapiens	17-20
3132714-1	1988	Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells.	Tetradecanoylphorbol Acetate	263-266	interleukin 2 receptor subunit alpha	Homo sapiens	81-92
3132714-1	1988	Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells.	Tetradecanoylphorbol Acetate	263-266	interleukin 2 receptor subunit alpha	Homo sapiens	106-110
3262467-2	1988	When stimulated with suboptimal concentrations of ionomycin and phorbol myristate acetate (PMA), the immature subpopulation of Lyt2-,L3T4- (2-4-) thymocytes responded to exogenous, purified IL-1 in a dose-dependent manner.	Tetradecanoylphorbol Acetate	64-89	CD8 antigen, alpha chain	Mus musculus	127-131
3262467-2	1988	When stimulated with suboptimal concentrations of ionomycin and phorbol myristate acetate (PMA), the immature subpopulation of Lyt2-,L3T4- (2-4-) thymocytes responded to exogenous, purified IL-1 in a dose-dependent manner.	Tetradecanoylphorbol Acetate	64-89	interleukin 1 complex	Mus musculus	190-194
3355171-3	1988	The induction of ODC activity correlates with the steady-state levels of ODC mRNA increased by TPA in T24 cells.	Tetradecanoylphorbol Acetate	95-98	ornithine decarboxylase 1	Homo sapiens	73-76
3262467-2	1988	When stimulated with suboptimal concentrations of ionomycin and phorbol myristate acetate (PMA), the immature subpopulation of Lyt2-,L3T4- (2-4-) thymocytes responded to exogenous, purified IL-1 in a dose-dependent manner.	Tetradecanoylphorbol Acetate	91-94	CD8 antigen, alpha chain	Mus musculus	127-131
3262467-2	1988	When stimulated with suboptimal concentrations of ionomycin and phorbol myristate acetate (PMA), the immature subpopulation of Lyt2-,L3T4- (2-4-) thymocytes responded to exogenous, purified IL-1 in a dose-dependent manner.	Tetradecanoylphorbol Acetate	91-94	interleukin 1 complex	Mus musculus	190-194
3132714-1	1988	Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells.	Tetradecanoylphorbol Acetate	263-266	interleukin 2 receptor subunit alpha	Homo sapiens	133-138
3355171-5	1988	Using the DNA-excess filter hybridization technique, we found that increased steady-state levels of ODC mRNA after TPA treatment may be the result of enhanced accumulation of newly synthesized ODC mRNA.	Tetradecanoylphorbol Acetate	115-118	ornithine decarboxylase 1	Homo sapiens	100-103
3355171-5	1988	Using the DNA-excess filter hybridization technique, we found that increased steady-state levels of ODC mRNA after TPA treatment may be the result of enhanced accumulation of newly synthesized ODC mRNA.	Tetradecanoylphorbol Acetate	115-118	ornithine decarboxylase 1	Homo sapiens	193-196
2899354-7	1988	Antibody L180/1, specific for the T11 (CD2) target structure (T11TS) on SE, homologous to the human CD2 ligand LFA-3, abolished the response to SENAGO alone or when combined with PEG or TPA.	Tetradecanoylphorbol Acetate	186-189	CD58 molecule	Homo sapiens	111-116
3355171-6	1988	The magnitude of the induction of ODC activity was proportional to the amount of ODC mRNA synthesis caused by TPA.	Tetradecanoylphorbol Acetate	110-113	ornithine decarboxylase 1	Homo sapiens	34-37
3134022-1	1988	Desensitization of pituitary gonadotropes by exposure to 10 nM gonadotropin-releasing hormone (GnRH) for 6 h severely impaired the luteinizing hormone (LH) response to a second 3-h treatment with GnRH, and reduced the secretory responses to 50 microM arachidonic acid (AA), 100 nM tetradecanoyl phorbol-13-acetate (TPA), and AA + TPA.	Tetradecanoylphorbol Acetate	315-318	gonadotropin releasing hormone 1	Homo sapiens	63-93
3134022-1	1988	Desensitization of pituitary gonadotropes by exposure to 10 nM gonadotropin-releasing hormone (GnRH) for 6 h severely impaired the luteinizing hormone (LH) response to a second 3-h treatment with GnRH, and reduced the secretory responses to 50 microM arachidonic acid (AA), 100 nM tetradecanoyl phorbol-13-acetate (TPA), and AA + TPA.	Tetradecanoylphorbol Acetate	315-318	gonadotropin releasing hormone 1	Homo sapiens	95-99
3134022-1	1988	Desensitization of pituitary gonadotropes by exposure to 10 nM gonadotropin-releasing hormone (GnRH) for 6 h severely impaired the luteinizing hormone (LH) response to a second 3-h treatment with GnRH, and reduced the secretory responses to 50 microM arachidonic acid (AA), 100 nM tetradecanoyl phorbol-13-acetate (TPA), and AA + TPA.	Tetradecanoylphorbol Acetate	315-318	gonadotropin releasing hormone 1	Homo sapiens	196-200
3134022-1	1988	Desensitization of pituitary gonadotropes by exposure to 10 nM gonadotropin-releasing hormone (GnRH) for 6 h severely impaired the luteinizing hormone (LH) response to a second 3-h treatment with GnRH, and reduced the secretory responses to 50 microM arachidonic acid (AA), 100 nM tetradecanoyl phorbol-13-acetate (TPA), and AA + TPA.	Tetradecanoylphorbol Acetate	330-333	gonadotropin releasing hormone 1	Homo sapiens	63-93
3134022-1	1988	Desensitization of pituitary gonadotropes by exposure to 10 nM gonadotropin-releasing hormone (GnRH) for 6 h severely impaired the luteinizing hormone (LH) response to a second 3-h treatment with GnRH, and reduced the secretory responses to 50 microM arachidonic acid (AA), 100 nM tetradecanoyl phorbol-13-acetate (TPA), and AA + TPA.	Tetradecanoylphorbol Acetate	330-333	gonadotropin releasing hormone 1	Homo sapiens	95-99
3134022-1	1988	Desensitization of pituitary gonadotropes by exposure to 10 nM gonadotropin-releasing hormone (GnRH) for 6 h severely impaired the luteinizing hormone (LH) response to a second 3-h treatment with GnRH, and reduced the secretory responses to 50 microM arachidonic acid (AA), 100 nM tetradecanoyl phorbol-13-acetate (TPA), and AA + TPA.	Tetradecanoylphorbol Acetate	330-333	gonadotropin releasing hormone 1	Homo sapiens	196-200
3133229-4	1988	The cell clone can be induced to accumulate substantial amounts of TcR alpha mRNA in response to phorbol myristate acetate (PMA) or calcium ionophore A23187.	Tetradecanoylphorbol Acetate	97-122	T cell receptor alpha constant	Homo sapiens	67-76
3133229-4	1988	The cell clone can be induced to accumulate substantial amounts of TcR alpha mRNA in response to phorbol myristate acetate (PMA) or calcium ionophore A23187.	Tetradecanoylphorbol Acetate	124-127	T cell receptor alpha constant	Homo sapiens	67-76
2453058-1	1988	Transcription factor activator protein 1 (AP1) interacts with the promoter region of a number of genes that are stimulated by growth factors present in serum or by agents such as phorbol 12-myristate 13-acetate (PMA) that partially mimic their action.	Tetradecanoylphorbol Acetate	179-210	jun proto-oncogene	Mus musculus	21-40
2453058-1	1988	Transcription factor activator protein 1 (AP1) interacts with the promoter region of a number of genes that are stimulated by growth factors present in serum or by agents such as phorbol 12-myristate 13-acetate (PMA) that partially mimic their action.	Tetradecanoylphorbol Acetate	179-210	jun proto-oncogene	Mus musculus	42-45
2453058-1	1988	Transcription factor activator protein 1 (AP1) interacts with the promoter region of a number of genes that are stimulated by growth factors present in serum or by agents such as phorbol 12-myristate 13-acetate (PMA) that partially mimic their action.	Tetradecanoylphorbol Acetate	212-215	jun proto-oncogene	Mus musculus	21-40
2453058-1	1988	Transcription factor activator protein 1 (AP1) interacts with the promoter region of a number of genes that are stimulated by growth factors present in serum or by agents such as phorbol 12-myristate 13-acetate (PMA) that partially mimic their action.	Tetradecanoylphorbol Acetate	212-215	jun proto-oncogene	Mus musculus	42-45
2453058-4	1988	A 2- to 3-fold activation was found after treatment with PMA or dibutyryl-cAMP, suggesting that different signal-transducing pathways could activate AP1 factor in these cells.	Tetradecanoylphorbol Acetate	57-60	jun proto-oncogene	Mus musculus	149-152
2452172-1	1988	One of the early events after stimulation of Swiss 3T3 cells with either platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-13-acetate (TPA), diacylglycerol, or several other mitogens is the near stoichiometric phosphorylation at tyrosine and serine of a scarce cytoplasmic protein (p42).	Tetradecanoylphorbol Acetate	112-149	cyclin-dependent kinase 20	Mus musculus	298-301
2452172-6	1988	Secondly, in PKC-deficient cells (cells in which PKC activity was reduced to undetectable levels by prolonged exposure to TPA), PDGF-induced p42 phosphorylation was reduced three- to fourfold.	Tetradecanoylphorbol Acetate	122-125	cyclin-dependent kinase 20	Mus musculus	141-144
3355561-0	1988	Induction of histidine decarboxylase of rat basophilic leukemia (2H3) cells stimulated by higher oligomeric IgE or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	115-140	histidine decarboxylase	Rattus norvegicus	13-36
3355561-2	1988	A similar increase in enzyme activity was observed in cells treated with phorbol myristate acetate (PMA) or oleoyl-acetylglycerol (OAG), which are known activators of protein kinase C. Removal of calcium from medium abolished the increase in HDC activity in response to higher oligomer but not that induced by PMA or OAG, suggesting that the increase in HDC activity may be mediated by protein kinase C. The increase in the HDC activity probably required induction of enzyme synthesis, because it was prevented by cycloheximide.	Tetradecanoylphorbol Acetate	73-98	histidine decarboxylase	Rattus norvegicus	242-245
3355561-2	1988	A similar increase in enzyme activity was observed in cells treated with phorbol myristate acetate (PMA) or oleoyl-acetylglycerol (OAG), which are known activators of protein kinase C. Removal of calcium from medium abolished the increase in HDC activity in response to higher oligomer but not that induced by PMA or OAG, suggesting that the increase in HDC activity may be mediated by protein kinase C. The increase in the HDC activity probably required induction of enzyme synthesis, because it was prevented by cycloheximide.	Tetradecanoylphorbol Acetate	73-98	histidine decarboxylase	Rattus norvegicus	354-357
3355561-2	1988	A similar increase in enzyme activity was observed in cells treated with phorbol myristate acetate (PMA) or oleoyl-acetylglycerol (OAG), which are known activators of protein kinase C. Removal of calcium from medium abolished the increase in HDC activity in response to higher oligomer but not that induced by PMA or OAG, suggesting that the increase in HDC activity may be mediated by protein kinase C. The increase in the HDC activity probably required induction of enzyme synthesis, because it was prevented by cycloheximide.	Tetradecanoylphorbol Acetate	73-98	histidine decarboxylase	Rattus norvegicus	354-357
3355561-2	1988	A similar increase in enzyme activity was observed in cells treated with phorbol myristate acetate (PMA) or oleoyl-acetylglycerol (OAG), which are known activators of protein kinase C. Removal of calcium from medium abolished the increase in HDC activity in response to higher oligomer but not that induced by PMA or OAG, suggesting that the increase in HDC activity may be mediated by protein kinase C. The increase in the HDC activity probably required induction of enzyme synthesis, because it was prevented by cycloheximide.	Tetradecanoylphorbol Acetate	100-103	histidine decarboxylase	Rattus norvegicus	242-245
3355561-2	1988	A similar increase in enzyme activity was observed in cells treated with phorbol myristate acetate (PMA) or oleoyl-acetylglycerol (OAG), which are known activators of protein kinase C. Removal of calcium from medium abolished the increase in HDC activity in response to higher oligomer but not that induced by PMA or OAG, suggesting that the increase in HDC activity may be mediated by protein kinase C. The increase in the HDC activity probably required induction of enzyme synthesis, because it was prevented by cycloheximide.	Tetradecanoylphorbol Acetate	100-103	histidine decarboxylase	Rattus norvegicus	354-357
3355561-2	1988	A similar increase in enzyme activity was observed in cells treated with phorbol myristate acetate (PMA) or oleoyl-acetylglycerol (OAG), which are known activators of protein kinase C. Removal of calcium from medium abolished the increase in HDC activity in response to higher oligomer but not that induced by PMA or OAG, suggesting that the increase in HDC activity may be mediated by protein kinase C. The increase in the HDC activity probably required induction of enzyme synthesis, because it was prevented by cycloheximide.	Tetradecanoylphorbol Acetate	100-103	histidine decarboxylase	Rattus norvegicus	354-357
3355150-3	1988	After mono- or diphosphorylated 20-kDa MLC from thrombin-stimulated platelets was digested with trypsin, the analysis using two-dimensional peptide mapping demonstrated that two different sites were phosphorylated by MLC kinase and protein kinase C, as noted in the case of 12-O-tetradecanoylphorbol-13-acetate-stimulated platelets (M. Naka, et al.	Tetradecanoylphorbol Acetate	274-310	myosin light chain kinase 3	Homo sapiens	217-227
3131167-6	1988	The TRH-stimulated phospholipase C activity was not attenuated following pretreatment with 12-O-tetradecanoylphorbol 3-acetate (TPA) to stimulate protein kinase C activity, and TRH also induced desensitization in the presence of the protein kinase C inhibitor polymyxin B.	Tetradecanoylphorbol Acetate	128-131	thyrotropin releasing hormone	Rattus norvegicus	4-7
3129665-9	1988	TPA-treated cells showed an increased responsiveness to TRH, whereas A23187-treated cells did not.	Tetradecanoylphorbol Acetate	0-3	thyrotropin releasing hormone	Rattus norvegicus	56-59
2450350-4	1988	LMW-BCGF- and anti-CD19-induced [Ca2+]i signals are similar to the sIgM or sIgD-mediated signals in that they are inhibited by prior treatment with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	148-179	CD19 molecule	Homo sapiens	19-23
3422232-8	1988	However, when the HL-60 cells were induced toward the monocytic lineage with phorbol 12-myristate 13-acetate, NE transcripts were lost even though transcripts for interleukin-1 beta were plentiful.	Tetradecanoylphorbol Acetate	77-108	elastase, neutrophil expressed	Homo sapiens	110-112
3345508-1	1988	Ornithine decarboxylase (ODC) and histidine decarboxylase (HDC) activities of rat colon mucosa were induced after intrarectal instillation of 12-o-tetradecanoylphorbol-13-acetate (TPA) and sodium deoxycholate.	Tetradecanoylphorbol Acetate	142-178	histidine decarboxylase	Rattus norvegicus	34-57
3345508-1	1988	Ornithine decarboxylase (ODC) and histidine decarboxylase (HDC) activities of rat colon mucosa were induced after intrarectal instillation of 12-o-tetradecanoylphorbol-13-acetate (TPA) and sodium deoxycholate.	Tetradecanoylphorbol Acetate	142-178	histidine decarboxylase	Rattus norvegicus	59-62
3345508-1	1988	Ornithine decarboxylase (ODC) and histidine decarboxylase (HDC) activities of rat colon mucosa were induced after intrarectal instillation of 12-o-tetradecanoylphorbol-13-acetate (TPA) and sodium deoxycholate.	Tetradecanoylphorbol Acetate	180-183	histidine decarboxylase	Rattus norvegicus	34-57
3345508-1	1988	Ornithine decarboxylase (ODC) and histidine decarboxylase (HDC) activities of rat colon mucosa were induced after intrarectal instillation of 12-o-tetradecanoylphorbol-13-acetate (TPA) and sodium deoxycholate.	Tetradecanoylphorbol Acetate	180-183	histidine decarboxylase	Rattus norvegicus	59-62
3345508-5	1988	These data are the first to show the induction of HDC activity in colon mucosa by TPA and sodium deoxycholate and suggest that the induction of activities in these two enzymes might be one mechanism of their action as cancer promoters.	Tetradecanoylphorbol Acetate	82-85	histidine decarboxylase	Rattus norvegicus	50-53
3422343-6	1988	We show here that when the tumour promoter 12-tetradecanoyl-phorbol-13-acetate (TPA) is applied to the skin of mice, very high levels of TGF-beta messenger RNA are induced in the epidermal cells.	Tetradecanoylphorbol Acetate	43-78	transforming growth factor, beta 1	Mus musculus	137-145
3422343-6	1988	We show here that when the tumour promoter 12-tetradecanoyl-phorbol-13-acetate (TPA) is applied to the skin of mice, very high levels of TGF-beta messenger RNA are induced in the epidermal cells.	Tetradecanoylphorbol Acetate	80-83	transforming growth factor, beta 1	Mus musculus	137-145
3257235-2	1988	Activation of protein kinase C by the phorbol ester, tetradecanoyl phorbol acetate or other phorbol esters increases the levels of the alpha and beta T cell receptor (TcR-alpha, TcR-beta) mRNA, whereas an increase in cytosolic free Ca2+, induced by ionomycin or other Ca2+ ionophores, results in a decrease of alpha and beta TcR mRNA levels.	Tetradecanoylphorbol Acetate	53-82	T cell receptor alpha constant	Homo sapiens	167-176
2452078-5	1988	The effects of bFGF on PRL secretion are potentiated by the addition of estradiol (maximally effective dose 100 pg/ml approximately 10(-10) M) and are further increased by the addition of the phorbol ester, phorbol myristate acetate.	Tetradecanoylphorbol Acetate	207-232	fibroblast growth factor 2	Rattus norvegicus	15-19
2841595-3	1988	SBP-binding activity is increased after treatment of cells with tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	79-115	selenium binding protein 1	Homo sapiens	0-3
2841595-3	1988	SBP-binding activity is increased after treatment of cells with tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	117-120	selenium binding protein 1	Homo sapiens	0-3
2841595-4	1988	The essential increase in a number of metaphases with chromosome endoreduplications in TPA-treated lymphocytes indicates that SBP may be involved in initiation of chromosome replication or in alteration of the mitotic spindle function.	Tetradecanoylphorbol Acetate	87-90	selenium binding protein 1	Homo sapiens	126-129
3125181-2	1988	Incubation of ortho[32P]phosphate-labeled Fao cells with TPA increased the phosphorylation of the insulin receptor 2-fold after 30 min.	Tetradecanoylphorbol Acetate	57-60	insulin receptor	Rattus norvegicus	98-114
3125181-8	1988	TPA treatment also decreased the Km of the insulin receptor for ATP.	Tetradecanoylphorbol Acetate	0-3	insulin receptor	Rattus norvegicus	43-59
3125181-9	1988	Incubation of the insulin receptor purified from TPA-treated cells with alkaline phosphatase decreased the phosphate content of the beta-subunit to the control level and reversed the inhibition, suggesting that the serine phosphorylation of the beta-subunit was responsible for the decreased tyrosine kinase activity.	Tetradecanoylphorbol Acetate	49-52	insulin receptor	Rattus norvegicus	18-34
3125181-10	1988	Our results support the notion that the insulin receptor is a substrate for protein kinase C in the Fao cell and that the increase in serine phosphorylation of the beta-subunit of the receptor produced by TPA treatment inhibited tyrosine kinase activity in vivo and in vitro.	Tetradecanoylphorbol Acetate	205-208	insulin receptor	Rattus norvegicus	40-56
2450126-1	1988	In the present study a unique antibody (NKI-L16) reacting with the alpha-chain of the human leukocyte function-associated Ag-1 (LFA-1) is described, which stimulates homotypic cell-cell interactions in a manner very similar to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in contrast to other anti-LFA-1 mAb which inhibit cell aggregation.	Tetradecanoylphorbol Acetate	227-264	integrin subunit alpha L	Homo sapiens	92-126
2450126-1	1988	In the present study a unique antibody (NKI-L16) reacting with the alpha-chain of the human leukocyte function-associated Ag-1 (LFA-1) is described, which stimulates homotypic cell-cell interactions in a manner very similar to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in contrast to other anti-LFA-1 mAb which inhibit cell aggregation.	Tetradecanoylphorbol Acetate	227-264	integrin subunit alpha L	Homo sapiens	128-133
2450126-1	1988	In the present study a unique antibody (NKI-L16) reacting with the alpha-chain of the human leukocyte function-associated Ag-1 (LFA-1) is described, which stimulates homotypic cell-cell interactions in a manner very similar to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in contrast to other anti-LFA-1 mAb which inhibit cell aggregation.	Tetradecanoylphorbol Acetate	266-269	integrin subunit alpha L	Homo sapiens	92-126
2450126-1	1988	In the present study a unique antibody (NKI-L16) reacting with the alpha-chain of the human leukocyte function-associated Ag-1 (LFA-1) is described, which stimulates homotypic cell-cell interactions in a manner very similar to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in contrast to other anti-LFA-1 mAb which inhibit cell aggregation.	Tetradecanoylphorbol Acetate	266-269	integrin subunit alpha L	Homo sapiens	128-133
2450126-6	1988	It is hypothesized that NKI-L16 or TPA can cause the LFA-1 molecule to convert from an inactive to an active configuration, thereby permitting binding of LFA-1 to its natural ligand.	Tetradecanoylphorbol Acetate	35-38	integrin subunit alpha L	Homo sapiens	53-58
2450126-6	1988	It is hypothesized that NKI-L16 or TPA can cause the LFA-1 molecule to convert from an inactive to an active configuration, thereby permitting binding of LFA-1 to its natural ligand.	Tetradecanoylphorbol Acetate	35-38	integrin subunit alpha L	Homo sapiens	154-159
3371541-6	1988	Levels of SCP2 in the membrane-free supernatant are increased 2-fold already after 2 min incubation with LH and remain elevated for 24 h. The same response occurs with cells preincubated in the presence of cycloheximide for 4 h. SCP2 levels are also 2-fold increased after incubation with dibutyryl cAMP or 4 beta-phorbol 12-myristate 13-acetate (PMA) whereas these compounds stimulate steroid production 5.5- and 2-fold respectively.	Tetradecanoylphorbol Acetate	307-345	sterol carrier protein 2	Rattus norvegicus	10-14
3371541-6	1988	Levels of SCP2 in the membrane-free supernatant are increased 2-fold already after 2 min incubation with LH and remain elevated for 24 h. The same response occurs with cells preincubated in the presence of cycloheximide for 4 h. SCP2 levels are also 2-fold increased after incubation with dibutyryl cAMP or 4 beta-phorbol 12-myristate 13-acetate (PMA) whereas these compounds stimulate steroid production 5.5- and 2-fold respectively.	Tetradecanoylphorbol Acetate	347-350	sterol carrier protein 2	Rattus norvegicus	10-14
2962643-2	1988	This analogue, tPA-Gly275, was very resistant to plasmin (EC 2.4.21.5) cleavage.	Tetradecanoylphorbol Acetate	15-18	plasminogen	Homo sapiens	49-56
2962643-3	1988	It has been used to gain information about the activity of the uncleaved one-chain tPA form, also when plasmin is generated as a result of a plasminogen activation reaction.	Tetradecanoylphorbol Acetate	83-86	plasminogen	Homo sapiens	103-110
3345508-0	1988	Induction of ornithine decarboxylase and histidine decarboxylase activities in rat colon mucosa after application of 12-o-tetradecanoylphorbol-13-acetate (TPA), sodium deoxycholate and indole.	Tetradecanoylphorbol Acetate	117-153	histidine decarboxylase	Rattus norvegicus	41-64
3345508-0	1988	Induction of ornithine decarboxylase and histidine decarboxylase activities in rat colon mucosa after application of 12-o-tetradecanoylphorbol-13-acetate (TPA), sodium deoxycholate and indole.	Tetradecanoylphorbol Acetate	155-158	histidine decarboxylase	Rattus norvegicus	41-64
3122755-1	1988	The addition of either recombinant human interleukin 1 (IL1 alpha) or 12-O-tetradecanoyl phorbol-13-acetate (TPA) to cultured rheumatoid synovial cells (RSC) caused dose-related increases in PGE production and cellular fructose 2,6-bisphosphate (Fru-2,6-P2).	Tetradecanoylphorbol Acetate	70-107	zinc finger and BTB domain containing 22	Homo sapiens	246-249
3122755-3	1988	A close association between increases in PGE production and Fru-2,6-P2 was demonstrated for both IL1- and TPA-stimulated cells.	Tetradecanoylphorbol Acetate	106-109	zinc finger and BTB domain containing 22	Homo sapiens	60-63
2850450-4	1988	It was also found that BB-1 expression decreased on P3HR-1 cells after activation of intracellular EBV genes by treating chemically with tumor-promoting agent (TPA) and n-butyrate, or on Raji cells on superinfection with EBV.	Tetradecanoylphorbol Acetate	160-163	CD80 molecule	Homo sapiens	23-27
3076454-4	1988	In contrast, K13 was consistently expressed in squamous cell carcinomas of the skin induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate (TPA), whereas papillomas obtained by the same two-stage protocol were distinctly heterogeneous with regard to the expression of this keratin.	Tetradecanoylphorbol Acetate	130-166	keratin 13	Mus musculus	13-16
3076454-4	1988	In contrast, K13 was consistently expressed in squamous cell carcinomas of the skin induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate (TPA), whereas papillomas obtained by the same two-stage protocol were distinctly heterogeneous with regard to the expression of this keratin.	Tetradecanoylphorbol Acetate	168-171	keratin 13	Mus musculus	13-16
3065654-3	1988	The increase of MHC class I antigen density (immunofluorescence intensity) induced by a phorbol ester (TPA) in monoblast U 937 lymphoma cell line was observed by immunocytofluorometry as a predominant tendency in several TPA-induction experiments, where a certain variability among individual experiments in TPA-induced MHC class I antigen alterations was observed.	Tetradecanoylphorbol Acetate	103-106	MHC class I antigen	Homo sapiens	16-35
3065654-3	1988	The increase of MHC class I antigen density (immunofluorescence intensity) induced by a phorbol ester (TPA) in monoblast U 937 lymphoma cell line was observed by immunocytofluorometry as a predominant tendency in several TPA-induction experiments, where a certain variability among individual experiments in TPA-induced MHC class I antigen alterations was observed.	Tetradecanoylphorbol Acetate	103-106	MHC class I antigen	Homo sapiens	320-339
3065654-3	1988	The increase of MHC class I antigen density (immunofluorescence intensity) induced by a phorbol ester (TPA) in monoblast U 937 lymphoma cell line was observed by immunocytofluorometry as a predominant tendency in several TPA-induction experiments, where a certain variability among individual experiments in TPA-induced MHC class I antigen alterations was observed.	Tetradecanoylphorbol Acetate	221-224	MHC class I antigen	Homo sapiens	16-35
3065654-3	1988	The increase of MHC class I antigen density (immunofluorescence intensity) induced by a phorbol ester (TPA) in monoblast U 937 lymphoma cell line was observed by immunocytofluorometry as a predominant tendency in several TPA-induction experiments, where a certain variability among individual experiments in TPA-induced MHC class I antigen alterations was observed.	Tetradecanoylphorbol Acetate	221-224	MHC class I antigen	Homo sapiens	16-35
2826275-7	1987	PMA had no effect on basal phosphoinositide or inositol phosphate levels, but attenuated the effects of TRH on these parameters.	Tetradecanoylphorbol Acetate	0-3	thyrotropin releasing hormone	Homo sapiens	104-107
3499217-1	1987	Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine.	Tetradecanoylphorbol Acetate	5-41	epidermal growth factor like 1	Rattus norvegicus	121-144
3499217-1	1987	Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine.	Tetradecanoylphorbol Acetate	5-41	epidermal growth factor like 1	Rattus norvegicus	146-149
3499217-1	1987	Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine.	Tetradecanoylphorbol Acetate	43-46	epidermal growth factor like 1	Rattus norvegicus	121-144
3499217-1	1987	Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine.	Tetradecanoylphorbol Acetate	43-46	epidermal growth factor like 1	Rattus norvegicus	146-149
3499217-5	1987	The binding of EGF was transiently down-regulated by TPA, then restored to control values 6 h later, whereas the binding of this factor was significantly increased at both the 12th and 24th h after PB addition.	Tetradecanoylphorbol Acetate	53-56	epidermal growth factor like 1	Rattus norvegicus	15-18
2856403-2	1987	In these basal conditions, the individual addition of TSH, insulin, insulin-like growth factor-I (IGF-I), phorbol 12-myristate 13-acetate (TPA), alpha 1-adrenergic agents, or A23187, increase c-myc and/or c-fos proto-oncogene expression.	Tetradecanoylphorbol Acetate	106-137	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	192-197
3117787-7	1987	In this study, TPA is shown to activate choline-phosphate cytidylyltransferase (EC 2.7.7.15), the regulatory enzyme of the CDP-choline pathway, by stimulating redistribution of the inactive cytosolic form of the enzyme to the membrane.	Tetradecanoylphorbol Acetate	15-18	cut-like homeobox 1	Rattus norvegicus	123-126
3319626-5	1987	When the cells were plated in the presence of TPA on pFn or on pFn-fragments, containing the cell binding site, all the cells adhered rapidly, spread extensively, organized prominent F-actin stress fibers and typical ventral plaques of vinculin and alpha-actinin.	Tetradecanoylphorbol Acetate	46-49	vinculin	Homo sapiens	236-244
3319626-8	1987	Both adhesion on pFn as well as formation of stress fibers in the presence of TPA could be prevented by the synthetic peptide Arg-Gly-Asp-Ser (RGDS).	Tetradecanoylphorbol Acetate	78-81	ral guanine nucleotide dissociation stimulator	Homo sapiens	143-147
3301843-7	1987	The phorbol ester phorbol 12-myristate 13-acetate (PMA) also induces c-myc and c-fos mRNAs without inducing DNA synthesis.	Tetradecanoylphorbol Acetate	18-49	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	69-74
3301843-7	1987	The phorbol ester phorbol 12-myristate 13-acetate (PMA) also induces c-myc and c-fos mRNAs without inducing DNA synthesis.	Tetradecanoylphorbol Acetate	51-54	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	69-74
3301843-8	1987	However, the mechanism of this induction appears to be different from the insulin-induced induction since pretreatment of cells with PMA blocks only the PMA-mediated, not the insulin-mediated, induction of c-myc and c-fos.	Tetradecanoylphorbol Acetate	133-136	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	206-211
24254684-1	1987	Tumor promoters, such as phorbol myristate acetate (PMA), facilitate carcinogenesis by mechanisms that may involve changes in intracellular Ca(2+) metabolism and distribution of Ca(2+), as well as activation of a Ca(2+)-and phospholipid-dependent protein kinase, referred to as protein kinase C. We compared the actions of PMA on GH3 cloned pituitary cells with those of thyrotropin releasing hormone (TRH), an established Ca(2+)-mobilizing agent.	Tetradecanoylphorbol Acetate	25-50	thyrotropin releasing hormone	Rattus norvegicus	371-400
24254684-1	1987	Tumor promoters, such as phorbol myristate acetate (PMA), facilitate carcinogenesis by mechanisms that may involve changes in intracellular Ca(2+) metabolism and distribution of Ca(2+), as well as activation of a Ca(2+)-and phospholipid-dependent protein kinase, referred to as protein kinase C. We compared the actions of PMA on GH3 cloned pituitary cells with those of thyrotropin releasing hormone (TRH), an established Ca(2+)-mobilizing agent.	Tetradecanoylphorbol Acetate	25-50	thyrotropin releasing hormone	Rattus norvegicus	402-405
24254684-1	1987	Tumor promoters, such as phorbol myristate acetate (PMA), facilitate carcinogenesis by mechanisms that may involve changes in intracellular Ca(2+) metabolism and distribution of Ca(2+), as well as activation of a Ca(2+)-and phospholipid-dependent protein kinase, referred to as protein kinase C. We compared the actions of PMA on GH3 cloned pituitary cells with those of thyrotropin releasing hormone (TRH), an established Ca(2+)-mobilizing agent.	Tetradecanoylphorbol Acetate	52-55	thyrotropin releasing hormone	Rattus norvegicus	371-400
24254684-1	1987	Tumor promoters, such as phorbol myristate acetate (PMA), facilitate carcinogenesis by mechanisms that may involve changes in intracellular Ca(2+) metabolism and distribution of Ca(2+), as well as activation of a Ca(2+)-and phospholipid-dependent protein kinase, referred to as protein kinase C. We compared the actions of PMA on GH3 cloned pituitary cells with those of thyrotropin releasing hormone (TRH), an established Ca(2+)-mobilizing agent.	Tetradecanoylphorbol Acetate	52-55	thyrotropin releasing hormone	Rattus norvegicus	402-405
3115657-4	1987	At low concentrations (0.1 microM), A23187 synergized maximally with PMA to induce proliferation, to increase IL-2R mRNA levels and the expression of membrane IL-2R, and to produce a low but sufficient accumulation of IL-2 mRNA and IL-2 secretion.	Tetradecanoylphorbol Acetate	69-72	interleukin 2 receptor subunit alpha	Homo sapiens	110-115
3115657-4	1987	At low concentrations (0.1 microM), A23187 synergized maximally with PMA to induce proliferation, to increase IL-2R mRNA levels and the expression of membrane IL-2R, and to produce a low but sufficient accumulation of IL-2 mRNA and IL-2 secretion.	Tetradecanoylphorbol Acetate	69-72	interleukin 2 receptor subunit alpha	Homo sapiens	159-164
3494505-8	1987	After removal of TPA, mutant M11 continued to grow while M12 died.	Tetradecanoylphorbol Acetate	17-20	olfactory receptor family 7 subfamily A member 40	Mus musculus	57-60
3494505-9	1987	Growth of M12 cells was TPA concentration dependent.	Tetradecanoylphorbol Acetate	24-27	olfactory receptor family 7 subfamily A member 40	Mus musculus	10-13
3494505-13	1987	After subcloning M12 cells, it was found that several subclones of M12 did not grow in response to TPA but did grow well in L-cell medium.	Tetradecanoylphorbol Acetate	99-102	olfactory receptor family 7 subfamily A member 40	Mus musculus	67-70
3106473-4	1987	In T cells, the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) induced IL 2-R expression and proliferation associated with cytosol-to-membrane PKC translocation.	Tetradecanoylphorbol Acetate	30-67	interleukin 2 receptor subunit beta	Homo sapiens	82-88
3106473-4	1987	In T cells, the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) induced IL 2-R expression and proliferation associated with cytosol-to-membrane PKC translocation.	Tetradecanoylphorbol Acetate	69-72	interleukin 2 receptor subunit beta	Homo sapiens	82-88
3106473-5	1987	A dose of TPA (1 to 4 ng/ml) that induced about 50% of the maximal activation of PKC in the enzymatic assay also induced half-maximal effects on cell proliferation, IL 2-R expression, and PKC redistribution in intact T cells.	Tetradecanoylphorbol Acetate	10-13	interleukin 2 receptor subunit beta	Homo sapiens	165-171
3104328-4	1987	Further, phorbol ester- and diacylglycerol-stimulated LH release, as well as inhibition by PMA of gonadotropin-releasing hormone (GnRH)-stimulated inositol phosphate production, were reduced by pretreatment with PMA.	Tetradecanoylphorbol Acetate	91-94	gonadotropin releasing hormone 1	Homo sapiens	98-128
2953669-6	1987	Expression of both receptors increased in a dose-dependent manner after incubation with f-met-leu-phe or phorbol myristate acetate; however, only CR3 expression was enhanced at very low concentrations of these stimuli.	Tetradecanoylphorbol Acetate	105-130	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	146-149
3102607-3	1987	After stimulation with phorbol myristic acetate (PMA) and interleukin 2, essentially normal levels of surface antigen receptor were expressed by the lpr Lyt-2- L3T4- subpopulation but remained undetectable in the corresponding normal immature thymocyte population.	Tetradecanoylphorbol Acetate	49-52	CD8 antigen, alpha chain	Mus musculus	153-158
3109389-8	1987	These results, together with previous findings which show that secretion can be mimicked by TPA and ionomycin, suggest that TRH-stimulated Na+/H+ exchange plays no part in the acute stimulation of secretion, but that TRH increases the pH-sensitivity of the antiport system during increased synthesis of prolactin and growth hormone.	Tetradecanoylphorbol Acetate	92-95	thyrotropin releasing hormone	Rattus norvegicus	124-127
2948635-7	1987	These results show that the induction of Ad5 E1 genes by TPA does not require their presence on infecting genomes, but suggest that inducibility of integrated, functionally expressed E1 genes can be influenced by factors other than their primary sequence.	Tetradecanoylphorbol Acetate	57-60	Alzheimer disease, familial, type 5	Homo sapiens	41-44
3104061-5	1987	Either accessory cells, RIF or the protein kinase C activator phorbol myristate acetate can substitute for each other and are equally active for the induction of IL 2 responsiveness in high-density Lyt-2+ T cells exposed to Con A.	Tetradecanoylphorbol Acetate	62-87	CD8 antigen, alpha chain	Mus musculus	198-203
3566711-2	1987	Stimulation of platelets by thrombin or 12-O-tetradecanoylphorbol 13-acetate increased pHi by about 0.11 pH unit above the resting value.	Tetradecanoylphorbol Acetate	40-76	glucose-6-phosphate isomerase	Homo sapiens	87-90
2881817-12	1987	On the other hand, when incubated with hCG, TPA inhibited both cAMP and testosterone production; the ED50s of hCG stimulation increased 4- to 10-fold with both parameters.	Tetradecanoylphorbol Acetate	44-47	hypertrichosis 2 (generalised, congenital)	Homo sapiens	39-42
2881817-12	1987	On the other hand, when incubated with hCG, TPA inhibited both cAMP and testosterone production; the ED50s of hCG stimulation increased 4- to 10-fold with both parameters.	Tetradecanoylphorbol Acetate	44-47	hypertrichosis 2 (generalised, congenital)	Homo sapiens	110-113
2946796-2	1986	Rapid induction of a phosphorylated 28 kD/32 kD disulfide-linked early activation antigen (EA 1) by 12-o-tetradecanoyl phorbol-13-acetate, mitogens, and antigens.	Tetradecanoylphorbol Acetate	100-137	CD69 molecule	Homo sapiens	91-95
2946796-3	1986	With human T cells activated by 12-o-tetradecanoyl phorbol-13-acetate (TPA) as immunogen, an IgG2a mAb, early activation antigen 1 (EA 1), was generated against a 60-kD protein with disulfide-linked 28-kD and 32-kD subunits.	Tetradecanoylphorbol Acetate	32-69	CD69 molecule	Homo sapiens	104-136
2946796-3	1986	With human T cells activated by 12-o-tetradecanoyl phorbol-13-acetate (TPA) as immunogen, an IgG2a mAb, early activation antigen 1 (EA 1), was generated against a 60-kD protein with disulfide-linked 28-kD and 32-kD subunits.	Tetradecanoylphorbol Acetate	71-74	CD69 molecule	Homo sapiens	104-136
2946796-7	1986	TPA-activated T cells expressed EA 1 as early as 30 min after activation.	Tetradecanoylphorbol Acetate	0-3	CD69 molecule	Homo sapiens	32-36
2946796-12	1986	TPA-induced EA 1 expression was independent of monocytes.	Tetradecanoylphorbol Acetate	0-3	CD69 molecule	Homo sapiens	12-16
2946796-13	1986	EA 1 expression was slightly delayed in T cells that were isolated without the rosette selection and treated with TPA.	Tetradecanoylphorbol Acetate	114-117	CD69 molecule	Homo sapiens	0-4
2946796-19	1986	B cells activated by TPA or anti-IgM antibody plus B cell growth factor expressed EA 1.	Tetradecanoylphorbol Acetate	21-24	CD69 molecule	Homo sapiens	82-86
2946796-21	1986	Repeated attempts to detect EA 1 on resting and TPA-activated monocytes and granulocytes have not been successful.	Tetradecanoylphorbol Acetate	48-51	CD69 molecule	Homo sapiens	28-32
2431900-1	1986	Expression of the myc and fos genes has been monitored in mouse primary keratinocytes after induction of terminal differentiation by calcium or tetradecanoylphorbol acetate (TPA).	Tetradecanoylphorbol Acetate	144-172	myelocytomatosis oncogene	Mus musculus	18-21
3017998-6	1986	The insulin receptor was found to behave differently in response to phorbol myristate acetate, however, in that only the occupied receptors were stimulated to internalize.	Tetradecanoylphorbol Acetate	68-93	insulin receptor	Homo sapiens	4-20
2948494-3	1986	With increasing times of incubation with PMA (10 s-5 min), the rise in [Ca2+]i induced by thrombin and the TxA2 mimetic, U46619, was increasingly inhibited (90-100% with 5 min incubation) and, correlating with this, thrombin-induced [3H]arachidonate, TxB2 and beta-thromboglobulin (beta TG) release were also inhibited.	Tetradecanoylphorbol Acetate	41-44	pro-platelet basic protein	Homo sapiens	260-280
3461785-0	1986	Dimethylsulfoxide, retinoic acid and 12-O-tetradecanoylphorbol-13-acetate induce a selective decrease in the phosphorylation of P150, a surface membrane phosphoprotein of HL60 cells resistant to adriamycin.	Tetradecanoylphorbol Acetate	37-73	chromatin assembly factor 1 subunit A	Homo sapiens	128-132
3461785-5	1986	Additional studies also show that treatment of resistant cells with TPA results in a major decrease in the in vivo phosphorylation of P150.	Tetradecanoylphorbol Acetate	68-71	chromatin assembly factor 1 subunit A	Homo sapiens	134-138
3487378-4	1986	The expression of Hex I was examined in 87 leukemia-lymphoma cell lines, in 14 B-lymphoblastoid cell lines, in 441 cases of leukemia-lymphoma (specimens containing 80% or more tumor cells), in 22 leukemia cell lines and in 14 cases of leukemia that had been treated with phorbolesters (TPA) for induction of differentiation, and in the mononuclear cell preparations separated from peripheral blood, lymph node, thymus, bone marrow, tonsil, liver, and spleen specimens from normal donors.	Tetradecanoylphorbol Acetate	286-289	hematopoietically expressed homeobox	Homo sapiens	18-21
3487378-9	1986	However, two out of two cases of multiple myeloma were Hex I-positive, and the Hex I expression could be induced by TPA in three of six B-cell chronic lymphocytic leukemia cases.	Tetradecanoylphorbol Acetate	116-119	hematopoietically expressed homeobox	Homo sapiens	79-82
3011686-1	1986	To elucidate the biological mechanisms of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phenotypic changes in HTLV-I virus-infected human T-cell line KH-2Lo cells, inhibitors of TPA-induced ornithine decarboxylase (ODC), protein kinases and calmodulin were examined for their effects on TPA-induced multinucleated cell formation and HTLV-I p19 antigen expression.	Tetradecanoylphorbol Acetate	42-78	ornithine decarboxylase 1	Homo sapiens	195-218
3011686-1	1986	To elucidate the biological mechanisms of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phenotypic changes in HTLV-I virus-infected human T-cell line KH-2Lo cells, inhibitors of TPA-induced ornithine decarboxylase (ODC), protein kinases and calmodulin were examined for their effects on TPA-induced multinucleated cell formation and HTLV-I p19 antigen expression.	Tetradecanoylphorbol Acetate	80-83	ornithine decarboxylase 1	Homo sapiens	195-218
3011686-1	1986	To elucidate the biological mechanisms of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phenotypic changes in HTLV-I virus-infected human T-cell line KH-2Lo cells, inhibitors of TPA-induced ornithine decarboxylase (ODC), protein kinases and calmodulin were examined for their effects on TPA-induced multinucleated cell formation and HTLV-I p19 antigen expression.	Tetradecanoylphorbol Acetate	80-83	ornithine decarboxylase 1	Homo sapiens	220-223
3011686-2	1986	Among the inhibitors of TPA-induced ODC activity, alpha-difluoromethyl ornithine (DFMO), 1,25(OH)2D3 and its analogues, and retinoic acid were tested.	Tetradecanoylphorbol Acetate	24-27	ornithine decarboxylase 1	Homo sapiens	36-39
3011686-6	1986	On the other hand, an inhibitor of ODC, DFMO, the protein kinase inhibitors, the calmodulin inhibitor and retinoic acid suppressed TPA-induced HTLV-I p19 expression but did not suppress multinucleated cell formation.	Tetradecanoylphorbol Acetate	131-134	ornithine decarboxylase 1	Homo sapiens	35-38
3007488-4	1986	TPA induced VL30 expression in the EGF-receptorless NR6 cell line, indicating that neither EGF ligand-receptor binding nor phosphorylation of the EGF receptor was required for induction of VL30 expression.	Tetradecanoylphorbol Acetate	0-3	cytokine receptor-like factor 1	Mus musculus	52-55
2415978-10	1985	Phorbol myristate acetate, a compound which does not stimulate cAMP generation but enhances the release of ACTH in AtT-20 cells, decreased the cytosolic calcium level.	Tetradecanoylphorbol Acetate	0-25	pro-opiomelanocortin-alpha	Mus musculus	107-111
3076326-0	1988	Mechanisms involved in ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate, a potent mouse skin tumor promoter and an activator of protein kinase C. ODC, the first enzyme in mammalian polyamine biosynthesis, is rapidly induced in response to a wide variety of growth stimuli.	Tetradecanoylphorbol Acetate	60-96	ornithine decarboxylase 1	Homo sapiens	171-174
3126073-5	1988	Apart from the synergy of anti-CD28 antibodies with phorbol myristate acetate and anti-CD3 antibodies, we found that anti-CD28 mAb were able to induce T cell mitogenesis in combination with an E rosette-blocking anti-CD2 antibody.	Tetradecanoylphorbol Acetate	52-77	CD28 molecule	Homo sapiens	122-126
3121729-15	1987	mRNA analysis of adult L3T4-/Lyt-2- thymocytes stimulated with A23187 and phorbol myristate acetate confirms that mRNA for both IL-4 and IFN-gamma is induced in adult L3T4-/Lyt-2- thymocytes.	Tetradecanoylphorbol Acetate	74-99	CD8 antigen, alpha chain	Mus musculus	29-34
3121729-15	1987	mRNA analysis of adult L3T4-/Lyt-2- thymocytes stimulated with A23187 and phorbol myristate acetate confirms that mRNA for both IL-4 and IFN-gamma is induced in adult L3T4-/Lyt-2- thymocytes.	Tetradecanoylphorbol Acetate	74-99	CD8 antigen, alpha chain	Mus musculus	173-178
3678602-8	1987	7, 995-1006) that, in the pituitary-derived GH4C1 cells, thyrotropin-releasing hormone or the tumor promoter TPA (12-O-tetradecanoylphorbol-13-acetate) stimulates the phosphorylation of two sets of cytoplasmic proteins related to the regulation of prolactin synthesis and release, respectively.	Tetradecanoylphorbol Acetate	114-150	thyrotropin releasing hormone	Rattus norvegicus	57-86
3878827-1	1985	4 beta-phorbol 12-myristate 13-acetate (PMA), a potent tumor promoter, was found to have a dual effect on interleukin 1-(IL 1) stimulated murine thymocyte cultures.	Tetradecanoylphorbol Acetate	0-38	interleukin 1 complex	Mus musculus	121-125
3878827-1	1985	4 beta-phorbol 12-myristate 13-acetate (PMA), a potent tumor promoter, was found to have a dual effect on interleukin 1-(IL 1) stimulated murine thymocyte cultures.	Tetradecanoylphorbol Acetate	40-43	interleukin 1 complex	Mus musculus	121-125
3355171-6	1988	The magnitude of the induction of ODC activity was proportional to the amount of ODC mRNA synthesis caused by TPA.	Tetradecanoylphorbol Acetate	110-113	ornithine decarboxylase 1	Homo sapiens	81-84
3355171-8	1988	Furthermore, as determined by the "nuclear runoff transcription assay," the rate of transcription of ODC-gene was increased by treatment of T24 cells with TPA.	Tetradecanoylphorbol Acetate	155-158	ornithine decarboxylase 1	Homo sapiens	101-104
3355171-11	1988	Taken together these results indicate that the TPA-increased synthesis of steady-state levels of ODC mRNA in T24 cells may be mediated by protein kinase C and is regulated at the transcriptional level.	Tetradecanoylphorbol Acetate	47-50	ornithine decarboxylase 1	Homo sapiens	97-100
3000458-12	1985	Treatment of 32P-labeled H-35 hepatoma cells with phorbol myristate acetate (PMA) results in a marked increase in serine phosphorylation of the insulin receptor beta subunit.	Tetradecanoylphorbol Acetate	50-75	insulin receptor	Rattus norvegicus	144-160
3162237-5	1988	The suppression of neurite outgrowth by sphingosine was antagonized by the addition of 12-O-tetradecanoylphorbol 13-acetate (TPA), which binds to and directly activates protein kinase C. In the presence of NGF, TPA treatment increased the incidence of neurite outgrowth, and this increase, in turn, was antagonized by sphingosine.	Tetradecanoylphorbol Acetate	87-123	nerve growth factor	Rattus norvegicus	206-209
3000458-12	1985	Treatment of 32P-labeled H-35 hepatoma cells with phorbol myristate acetate (PMA) results in a marked increase in serine phosphorylation of the insulin receptor beta subunit.	Tetradecanoylphorbol Acetate	77-80	insulin receptor	Rattus norvegicus	144-160
3159791-3	1985	In this study, by using radiolabeled Fab fragments of a monoclonal anti-CR1 antibody to tag the receptor and acid elution of surface-bound Fab, we showed that both phorbol myristate acetate and phorbol dibutyrate induced internalization of the C3b receptor; this occurred in a dose- and time-dependent manner in the absence of occupancy of the receptor by ligand.	Tetradecanoylphorbol Acetate	164-189	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	72-75
2830495-2	1987	The binding of monoclonal antibodies to the CD28 antigen on purified T cells does not result in proliferation; however, previous studies have shown that the combination of CD28 stimulation and protein kinase C activation by phorbol myristate acetate (PMA) results in T-cell proliferation that is independent of both accessory cells and activation of the T-cell receptor-CD3 complex.	Tetradecanoylphorbol Acetate	224-249	CD28 molecule	Homo sapiens	44-48
2830495-2	1987	The binding of monoclonal antibodies to the CD28 antigen on purified T cells does not result in proliferation; however, previous studies have shown that the combination of CD28 stimulation and protein kinase C activation by phorbol myristate acetate (PMA) results in T-cell proliferation that is independent of both accessory cells and activation of the T-cell receptor-CD3 complex.	Tetradecanoylphorbol Acetate	251-254	CD28 molecule	Homo sapiens	44-48
3162237-5	1988	The suppression of neurite outgrowth by sphingosine was antagonized by the addition of 12-O-tetradecanoylphorbol 13-acetate (TPA), which binds to and directly activates protein kinase C. In the presence of NGF, TPA treatment increased the incidence of neurite outgrowth, and this increase, in turn, was antagonized by sphingosine.	Tetradecanoylphorbol Acetate	125-128	nerve growth factor	Rattus norvegicus	206-209
2825684-2	1987	Addition of the tumor promoter phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), at concentrations which activate pituitary protein C kinase, to cultured pituitary cells resulted in up-regulation of GnRH receptors (155% at 4 h).	Tetradecanoylphorbol Acetate	45-81	gonadotropin releasing hormone 1	Homo sapiens	207-211
2825684-2	1987	Addition of the tumor promoter phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), at concentrations which activate pituitary protein C kinase, to cultured pituitary cells resulted in up-regulation of GnRH receptors (155% at 4 h).	Tetradecanoylphorbol Acetate	83-86	gonadotropin releasing hormone 1	Homo sapiens	207-211
3162237-5	1988	The suppression of neurite outgrowth by sphingosine was antagonized by the addition of 12-O-tetradecanoylphorbol 13-acetate (TPA), which binds to and directly activates protein kinase C. In the presence of NGF, TPA treatment increased the incidence of neurite outgrowth, and this increase, in turn, was antagonized by sphingosine.	Tetradecanoylphorbol Acetate	211-214	nerve growth factor	Rattus norvegicus	206-209
2825684-3	1987	The stimulatory effect of GnRH on [3H]inositol phosphates (Ins-P) production in myo-[2-3H]inositol prelabeled pituitary cells was not inhibited by prior treatment of the cells with TPA (10(-9)-10(-7) M).	Tetradecanoylphorbol Acetate	181-184	gonadotropin releasing hormone 1	Homo sapiens	26-30
3160693-6	1985	Simultaneous addition of TPA with the ionophore ionomycin (100 nM) reconstituted a TRH-like spike, nadir and plateau of [Ca2+]i.	Tetradecanoylphorbol Acetate	25-28	thyrotropin releasing hormone	Rattus norvegicus	83-86
2825684-4	1987	Higher concentrations of TPA (10(-6)-10(-5) M) inhibited the effect of GnRH on [3H]Ins-P production.	Tetradecanoylphorbol Acetate	25-28	gonadotropin releasing hormone 1	Homo sapiens	71-75
3125181-1	1988	The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the function of the insulin receptor was examined in intact hepatoma cells (Fao) and in solubilized extracts purified by wheat germ agglutinin chromatography.	Tetradecanoylphorbol Acetate	14-50	insulin receptor	Rattus norvegicus	80-96
3156597-4	1985	Phosphorylation of endogenous proteins from HL-60 cells by the enzyme, with or without being further augmented by TPA, was inhibited by CP-46,665-1 as well as by alkyllysophospholipid (an antineoplastic agent).	Tetradecanoylphorbol Acetate	114-117	cytochrome P450 family 46 subfamily A member 1	Homo sapiens	136-147
3125181-1	1988	The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the function of the insulin receptor was examined in intact hepatoma cells (Fao) and in solubilized extracts purified by wheat germ agglutinin chromatography.	Tetradecanoylphorbol Acetate	52-55	insulin receptor	Rattus norvegicus	80-96
2829888-2	1988	(b) phosphorylation of membrane associated vimentin is stimulated in phorbol 12-myristate 13-acetate treated neutrophil membranes, suggesting that vimentin can be a substrate for membrane associated protein kinase C and (c) phorbol 12-myristate 13-acetate also stimulates the phosphorylation of vimentin in 32P-labeled intact neutrophils.	Tetradecanoylphorbol Acetate	69-100	vimentin	Oryctolagus cuniculus	43-51
3155775-1	1985	Phorbol myristate acetate (PMA) has been reported to confer on the C3b receptor (CR1) of neutrophils a capacity for phagocytosis of particles bearing C3b without the involvement of other membrane receptors.	Tetradecanoylphorbol Acetate	0-25	endogenous retrovirus group K member 3	Homo sapiens	67-70
3663711-3	1987	During the activation of neutrophils with serum-opsonised zymosan and the tumour-promoting phorbol diester 12-O-tetradecanoylphorbol 13-acetate, the activity of glyoxalase I increases and the activity of glyoxalase II decreases by 20-40% of their activities in resting cells, in the initial 10 min of the activation period.	Tetradecanoylphorbol Acetate	107-143	hydroxyacylglutathione hydrolase	Homo sapiens	204-217
3155775-1	1985	Phorbol myristate acetate (PMA) has been reported to confer on the C3b receptor (CR1) of neutrophils a capacity for phagocytosis of particles bearing C3b without the involvement of other membrane receptors.	Tetradecanoylphorbol Acetate	0-25	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	81-84
2829888-2	1988	(b) phosphorylation of membrane associated vimentin is stimulated in phorbol 12-myristate 13-acetate treated neutrophil membranes, suggesting that vimentin can be a substrate for membrane associated protein kinase C and (c) phorbol 12-myristate 13-acetate also stimulates the phosphorylation of vimentin in 32P-labeled intact neutrophils.	Tetradecanoylphorbol Acetate	69-100	vimentin	Oryctolagus cuniculus	147-155
2829888-2	1988	(b) phosphorylation of membrane associated vimentin is stimulated in phorbol 12-myristate 13-acetate treated neutrophil membranes, suggesting that vimentin can be a substrate for membrane associated protein kinase C and (c) phorbol 12-myristate 13-acetate also stimulates the phosphorylation of vimentin in 32P-labeled intact neutrophils.	Tetradecanoylphorbol Acetate	69-100	vimentin	Oryctolagus cuniculus	147-155
3970979-0	1985	Comparison of the inhibitory effects of diverse amino acids and amino acid analogs on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in isolated epidermal cells.	Tetradecanoylphorbol Acetate	86-122	ornithine decarboxylase 1	Homo sapiens	131-154
3970979-1	1985	At a concentration of 1.25 mM, 14 amino acids were capable of inhibiting the induction of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) activity by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in isolated epidermal cells.	Tetradecanoylphorbol Acetate	186-222	ornithine decarboxylase 1	Homo sapiens	90-113
2829888-2	1988	(b) phosphorylation of membrane associated vimentin is stimulated in phorbol 12-myristate 13-acetate treated neutrophil membranes, suggesting that vimentin can be a substrate for membrane associated protein kinase C and (c) phorbol 12-myristate 13-acetate also stimulates the phosphorylation of vimentin in 32P-labeled intact neutrophils.	Tetradecanoylphorbol Acetate	224-255	vimentin	Oryctolagus cuniculus	43-51
3970979-1	1985	At a concentration of 1.25 mM, 14 amino acids were capable of inhibiting the induction of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) activity by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in isolated epidermal cells.	Tetradecanoylphorbol Acetate	224-227	ornithine decarboxylase 1	Homo sapiens	90-113
2896538-3	1987	In this system we have found that the cells release GH in response to low concentrations of TPA: the EC50 was 0.23 +/- 0.05 nM (n = 6) and the maximal concentration was 5 nM.	Tetradecanoylphorbol Acetate	92-95	gonadotropin releasing hormone receptor	Rattus norvegicus	52-54
3970979-2	1985	The greatest percentages of inhibition of TPA-induced epidermal ornithine decarboxylase activity were as follows: cysteine, 98%; tryptophan, 74%; methionine, 64%; phenylalanine, 51%; glycine, 44%; asparagine, 43%; glutamic acid, 42%; leucine, 40%; and arginine, 39%.	Tetradecanoylphorbol Acetate	42-45	ornithine decarboxylase 1	Homo sapiens	64-87
2831237-8	1988	Whereas IFN-alpha 2 induced an increase in the activity of 2",5"-oligoadenylate (2-5A) synthetase, the addition of TPA to IFN-alpha 2 caused a significant decrease in the activity of this enzyme.	Tetradecanoylphorbol Acetate	115-118	interferon alpha 2	Homo sapiens	122-133
2981678-1	1985	The mechanism(s) of action of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on rat (r) GH release was studied in primary rat pituitary cell cultures.	Tetradecanoylphorbol Acetate	69-72	gonadotropin releasing hormone receptor	Rattus norvegicus	85-87
2896538-4	1987	However, the maximal TPA-induced GH release was only 34 +/- 5% (n = 7) of the GH released by maximal growth hormone releasing factor (GRF) suggesting TPA releases a subpool of stored GH.	Tetradecanoylphorbol Acetate	21-24	gonadotropin releasing hormone receptor	Rattus norvegicus	33-35
2896538-5	1987	Both somatostatin and insulin-like growth factor I inhibit GH release stimulated by TPA to the same extent as that stimulated by GRF, showing that the normal inhibitory control mechanism of release is not altered.	Tetradecanoylphorbol Acetate	84-87	gonadotropin releasing hormone receptor	Rattus norvegicus	59-61
2896538-6	1987	Incubation in a low calcium medium that totally blocks GRF-stimulated GH release also inhibits TPA-stimulated GH release.	Tetradecanoylphorbol Acetate	95-98	growth hormone releasing hormone	Rattus norvegicus	55-58
2896538-6	1987	Incubation in a low calcium medium that totally blocks GRF-stimulated GH release also inhibits TPA-stimulated GH release.	Tetradecanoylphorbol Acetate	95-98	gonadotropin releasing hormone receptor	Rattus norvegicus	70-72
2896538-7	1987	The calcium channel blockers nifedipine and diltiazem both partly inhibit GRF- and TPA-stimulated GH release, showing some component of the calcium necessary for GH release arises from influx across the cell membrane.	Tetradecanoylphorbol Acetate	83-86	gonadotropin releasing hormone receptor	Rattus norvegicus	98-100
3123107-4	1987	The results demonstrate that following stimulation with PMA and A23187, purified T cells from elderly subjects demonstrate low levels of IL-2 production, IL-2R expression and cell proliferation.	Tetradecanoylphorbol Acetate	56-59	interleukin 2 receptor subunit alpha	Homo sapiens	154-159
2469882-7	1988	TPA induced translocation of [35S]methionine-prelabeled cytosolic 80 kDa PKC to membranes followed by complete degradation of the enzyme (t1/2 = 2 h) without affecting PKC synthesis.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 receptor like 1	Homo sapiens	138-148
3116092-7	1987	In contrast, PMA was able to induce IL-1 production by both C3H/He and C3H/HeJ macrophages without increasing intracellular Ca2+.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 complex	Mus musculus	36-40
2454379-0	1988	Expression of CD 19 antigen on acute monoblastic leukemia cells at diagnosis and after TPA-induced differentiation.	Tetradecanoylphorbol Acetate	87-90	CD19 molecule	Homo sapiens	14-19
3115340-3	1987	Cell incubation with phorbol myristate acetate (PMA) increased the expression of B4 antigen and significantly decreased the proportion of My9+ and IL2-R-bearing cells.	Tetradecanoylphorbol Acetate	21-46	interleukin 2 receptor subunit alpha	Homo sapiens	147-152
3115340-3	1987	Cell incubation with phorbol myristate acetate (PMA) increased the expression of B4 antigen and significantly decreased the proportion of My9+ and IL2-R-bearing cells.	Tetradecanoylphorbol Acetate	48-51	interleukin 2 receptor subunit alpha	Homo sapiens	147-152
3115340-7	1987	PMA-treated blast cells, however, generated B cell colonies in the presence of rIL2, thus suggesting that PMA could induce functional IL2-R on immature leukemic B cells.	Tetradecanoylphorbol Acetate	0-3	interleukin 2 receptor subunit alpha	Homo sapiens	134-139
3115340-7	1987	PMA-treated blast cells, however, generated B cell colonies in the presence of rIL2, thus suggesting that PMA could induce functional IL2-R on immature leukemic B cells.	Tetradecanoylphorbol Acetate	106-109	interleukin 2 receptor subunit alpha	Homo sapiens	134-139
2454379-5	1988	After a 48-hr culture in the presence of TPA, most cells became adherent and lost CD 19 antigen, whereas CD 14 was still expressed with only minimal changes.	Tetradecanoylphorbol Acetate	41-44	CD19 molecule	Homo sapiens	82-87
2971842-2	1988	CD13 expression appeared to be independent of maturation since it could be induced more readily in cultures which did not contain the differentiation promoter 12-O-tetradecanoyl-phorbol 13 acetate (TPA).	Tetradecanoylphorbol Acetate	159-196	alanyl aminopeptidase, membrane	Homo sapiens	0-4
3683847-8	1987	Phorbol 12-myristate 13-acetate had no effect on the pH of cell bodies of growing cells and increased pH of cells deprived of nerve growth factor by less than 0.05 pH units.	Tetradecanoylphorbol Acetate	0-31	nerve growth factor	Rattus norvegicus	126-145
2971842-2	1988	CD13 expression appeared to be independent of maturation since it could be induced more readily in cultures which did not contain the differentiation promoter 12-O-tetradecanoyl-phorbol 13 acetate (TPA).	Tetradecanoylphorbol Acetate	198-201	alanyl aminopeptidase, membrane	Homo sapiens	0-4
2827396-4	1987	Relative to PMN from saline-injected controls, PMN from LPS-treated rabbits released markedly greater amounts of O2- in response to 10 ng/ml phorbol myristate acetate (PMA) as measured by nmol cytochrome C reduced in 20 minutes (40.8 +/- 7.8 for LPS-treated PMN versus 10.1 +/- 1.6 for control, p less than 0.01).	Tetradecanoylphorbol Acetate	141-166	cytochrome c	Oryctolagus cuniculus	193-205
2827396-4	1987	Relative to PMN from saline-injected controls, PMN from LPS-treated rabbits released markedly greater amounts of O2- in response to 10 ng/ml phorbol myristate acetate (PMA) as measured by nmol cytochrome C reduced in 20 minutes (40.8 +/- 7.8 for LPS-treated PMN versus 10.1 +/- 1.6 for control, p less than 0.01).	Tetradecanoylphorbol Acetate	168-171	cytochrome c	Oryctolagus cuniculus	193-205
20501269-2	1988	TPA, forskolin and dibutyryl cAMP significantly increased specific activity of choline acetyltransferase.	Tetradecanoylphorbol Acetate	0-3	choline acetyltransferase	Mus musculus	79-104
2822168-4	1987	Stimulation of these pre-T-ALL cells with 12-0-tetradecanoylphorbol-13-acetate (TPA) induced only CD25 (Tac) antigen but no other T cell antigens.	Tetradecanoylphorbol Acetate	80-83	interleukin 2 receptor subunit alpha	Homo sapiens	98-102
2822168-7	1987	TPA induced the differentiation of the more mature pre-T-ALL cells of this case in vitro, and not only CD25 (Tac) antigen but also CD4 and CD8 antigens appeared on the cell surface.	Tetradecanoylphorbol Acetate	0-3	interleukin 2 receptor subunit alpha	Homo sapiens	103-107
3475147-2	1987	PMA, PDBu and the diacylglycerol, OAG, all caused a dose-dependent and slow (max by 15 min) release of small amounts of lysozyme with much less beta-glucuronidase and no release of cytoplasmic lactate dehydrogenase.	Tetradecanoylphorbol Acetate	0-3	glucuronidase beta	Homo sapiens	144-162
3621192-9	1987	It has also been found that treatment of cells with 12-O-tetradecanoylphorbol-13-acetate followed by [14C]glucosamine labeling results in a selective decrease in the glycosylation of p150 of sensitive and resistant cells.	Tetradecanoylphorbol Acetate	52-88	chromatin assembly factor 1 subunit A	Homo sapiens	183-187
3040449-1	1987	The effect of the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) on cytoplasmic pH (pHi) and H+ extrusion was studied in the human monoblastic cell line U-937.	Tetradecanoylphorbol Acetate	48-84	glucose-6-phosphate isomerase	Homo sapiens	110-113
3040449-1	1987	The effect of the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) on cytoplasmic pH (pHi) and H+ extrusion was studied in the human monoblastic cell line U-937.	Tetradecanoylphorbol Acetate	86-89	glucose-6-phosphate isomerase	Homo sapiens	110-113
3621192-10	1987	TPA has an identical effect on the phosphorylation of p150 in cells resistant to drug.	Tetradecanoylphorbol Acetate	0-3	chromatin assembly factor 1 subunit A	Homo sapiens	54-58
3040449-2	1987	About 2 min after addition of TPA, pHi started to increase and reached a steady state 10-15 min later.	Tetradecanoylphorbol Acetate	30-33	glucose-6-phosphate isomerase	Homo sapiens	35-38
3621459-6	1987	The order of activity, as measured by inhibition of H2O2 formation by TPA-activated PMNs during incubation at 37 degrees C for 30 min, was (in descending order): PtI-1 greater than or equal to PCI-2 greater than PtI-2 greater than COI greater than BBI greater than or equal to TOOI greater than LBI greater than SBTI.	Tetradecanoylphorbol Acetate	70-73	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	162-167
3040449-4	1987	The TPA-induced increase in pHi was independent of the presence of extracellular Na+.	Tetradecanoylphorbol Acetate	4-7	glucose-6-phosphate isomerase	Homo sapiens	28-31
2828340-3	1987	On the other hand, the tumor promoter, tetradecanoyl phorbol acetate (TPA), suppressed the TRH-induced hydrolysis of PIP2.	Tetradecanoylphorbol Acetate	39-68	thyrotropin releasing hormone	Rattus norvegicus	91-94
3495533-5	1987	Both PMA and carbachol promoted the phosphorylation of the ribosomal protein S6 and activated an S6 protein kinase in the normal but not in the protein kinase C-deficient cells.	Tetradecanoylphorbol Acetate	5-8	ribosomal protein S6	Homo sapiens	59-79
2828340-3	1987	On the other hand, the tumor promoter, tetradecanoyl phorbol acetate (TPA), suppressed the TRH-induced hydrolysis of PIP2.	Tetradecanoylphorbol Acetate	70-73	thyrotropin releasing hormone	Rattus norvegicus	91-94
2958480-7	1987	Stimulation of PMN for 25 min with phorbol myristate acetate (PMA) dramatically enhances binding of C3bi-coated particles, and the CR3 on such stimulated cells was observed in clusters containing more than six gold particles.	Tetradecanoylphorbol Acetate	35-60	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	131-134
2881980-1	1987	Incubation of rat pheochromocytoma PC12 cells with 4 beta-phorbol-12 beta-myristate-13 alpha-acetate (PMA), an activator of Ca2+/phospholipid-dependent protein kinase (protein kinase C), or forskolin, an activator of adenylate cyclase, is associated with increased activity and enhanced phosphorylation of tyrosine hydroxylase.	Tetradecanoylphorbol Acetate	102-105	tyrosine hydroxylase	Rattus norvegicus	306-326
2958480-7	1987	Stimulation of PMN for 25 min with phorbol myristate acetate (PMA) dramatically enhances binding of C3bi-coated particles, and the CR3 on such stimulated cells was observed in clusters containing more than six gold particles.	Tetradecanoylphorbol Acetate	62-65	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	131-134
3566738-1	1987	Studies have been carried out on intact human lung fibroblasts (HLF) in situ to investigate the effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the anti-tumor promoter retinoic acid (RA) on ecto-protein kinases.	Tetradecanoylphorbol Acetate	125-161	tripartite motif containing 33	Homo sapiens	218-222
3566738-2	1987	The ecto-kinase reaction of the HLF-cells was cAMP-independent, showed an apparent Km for ATP of 6.99 +/- 0.35 (microM) and was substantially inhibited by TPA and RA.	Tetradecanoylphorbol Acetate	155-158	tripartite motif containing 33	Homo sapiens	4-8
3118114-6	1987	Cross-linking of 125I-labeled IL-2 to TPA activated B cell precursor ALL revealed the 55 kD Tac/CD25 protein and an additional protein of 75 kD.	Tetradecanoylphorbol Acetate	38-41	interleukin 2 receptor subunit alpha	Homo sapiens	96-100
3566738-7	1987	The drop in ecto-kinase activity of HLF-cells in situ caused by TPA, RA and the diacylglycerols was accompanied by an increase in total basal-(Mg++-dependent) protein kinase activity present in extracts of treated cells.	Tetradecanoylphorbol Acetate	64-67	tripartite motif containing 33	Homo sapiens	12-16
3566738-8	1987	The results suggest an important role of ecto-kinase in the response of intact cells to TPA and RA.	Tetradecanoylphorbol Acetate	88-91	tripartite motif containing 33	Homo sapiens	41-45
2957693-3	1987	While the activation of purified quiescent B cells with phorbol 12-myristate 13-acetate led to the induction of 45-kDa CD23 at the surface membrane, the inclusion of IgE increased CD23 expression by a factor of approximately equal to 5.	Tetradecanoylphorbol Acetate	56-87	Fc epsilon receptor II	Homo sapiens	119-123
3469455-5	1987	TPA (10 and 100 nM) decreased the ODC activity of cells, and capsaicin (100 microM) induced ODC by 220%.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase 1	Homo sapiens	34-37
3469455-9	1987	Enhancement of PA activity and decrease in ODC by TPA are found in all three human epithelial cell types.	Tetradecanoylphorbol Acetate	50-53	ornithine decarboxylase 1	Homo sapiens	43-46
3881187-2	1985	High levels of MIF activity were demonstrated in the supernatants of two hybridoma lines, T-CEMA and T-CEMB but not of CEM-WH4 when stimulated with phorbol myristate acetate and phytohemagglutinin.	Tetradecanoylphorbol Acetate	148-173	macrophage migration inhibitory factor	Homo sapiens	15-18
2440878-4	1987	In addition to the alpha, beta, and gamma chains of fibrinogen, other acute phase response mRNAs are induced by 12-O-tetradecanoylphorbol-13-acetate including alpha 2-macroglobulin.	Tetradecanoylphorbol Acetate	112-148	alpha-2-macroglobulin	Rattus norvegicus	159-180
2864293-0	1985	Transglutaminase activity increases in HL60 cells induced to differentiate with retinoic acid and TPA but not with DMSO.	Tetradecanoylphorbol Acetate	98-101	transglutaminase 1	Homo sapiens	0-16
2864293-2	1985	HL60 cells induced to differentiate into monocytes by a phorbol ester tetradecanoylphorbol-12-myristate-13-acetate (TPA) had a greater than 840-fold increase in TGase activity on day 7.	Tetradecanoylphorbol Acetate	116-119	transglutaminase 1	Homo sapiens	161-166
3029093-3	1987	The activation signals provided by PHA and IL1 were replaced by the Ca2+ ionophore, ionomycin, and the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), respectively.	Tetradecanoylphorbol Acetate	156-159	interleukin 1 complex	Mus musculus	43-46
2893506-2	1987	IL-2-R gene expression is induced by pharmacological agents including calcium ions, phorbol esters such as phorbol myristate acetate (PMA) and forskolin (FK), a direct activator of adenylate cyclase.	Tetradecanoylphorbol Acetate	107-132	interleukin 2 receptor subunit alpha	Homo sapiens	0-6
2893506-2	1987	IL-2-R gene expression is induced by pharmacological agents including calcium ions, phorbol esters such as phorbol myristate acetate (PMA) and forskolin (FK), a direct activator of adenylate cyclase.	Tetradecanoylphorbol Acetate	134-137	interleukin 2 receptor subunit alpha	Homo sapiens	0-6
3496927-9	1987	Only cells activated with TPA coexpressed B1 and T1 as well as B5 and IL-2R.	Tetradecanoylphorbol Acetate	26-29	interleukin 2 receptor subunit alpha	Homo sapiens	70-75
6441115-10	1984	Murine thymocytes incubated with PMA for 30 min or with ConA for 4 hr (mitogen-pulsed T-cells) failed to bind the anti-IL-2 receptor antibody AMT-13 and to absorb IL-2 activity present in semipurified IL-2 preparations, but they proliferated vigorously in response to the same IL-2 preparations.	Tetradecanoylphorbol Acetate	33-36	interleukin 2 receptor subunit beta	Homo sapiens	119-132
3624319-1	1987	We compared transferrin receptor (TfR) expression on human peripheral blood lymphocytes (PBL) activated by phorbol myristate acetate (PMA) or L-phytohemagglutinin (LPHA) using two techniques: (1) 125I-iron-saturated transferrin (FeTf) binding, (2) reactivity with monoclonal anti-TfR antibodies--OKT9 and B3/25.	Tetradecanoylphorbol Acetate	107-132	transferrin receptor	Homo sapiens	12-32
6393128-3	1984	PMA (1 microgram/ml) stimulated the phosphorylation of the beta subunit of insulin receptor purified from [32P]phosphate-labeled Fao cells by 1.3-fold in the absence of insulin.	Tetradecanoylphorbol Acetate	0-3	insulin receptor	Rattus norvegicus	75-91
3114599-10	1987	In contrast to the stimulatory effect of A23187, the PMA-induced liberation of neutrophil elastase was attenuated, but not completely abolished, by complexation of extracellular calcium with EDTA.	Tetradecanoylphorbol Acetate	53-56	elastase, neutrophil expressed	Homo sapiens	79-98
3114599-11	1987	Both 10(-4) M verapamil (-43%) and 10(-5) M trifluoperazine (-42%) were able to reduce the PMA-induced release of neutrophil elastase.	Tetradecanoylphorbol Acetate	91-94	elastase, neutrophil expressed	Homo sapiens	114-133
3624319-1	1987	We compared transferrin receptor (TfR) expression on human peripheral blood lymphocytes (PBL) activated by phorbol myristate acetate (PMA) or L-phytohemagglutinin (LPHA) using two techniques: (1) 125I-iron-saturated transferrin (FeTf) binding, (2) reactivity with monoclonal anti-TfR antibodies--OKT9 and B3/25.	Tetradecanoylphorbol Acetate	107-132	transferrin receptor	Homo sapiens	34-37
6430792-5	1984	PMA activation in the presence of cytochalasin B augments the release of lysozyme and initiates the release of beta glucuronidase through recruitment of the azurophilic granule but has no incremental effect on the release of vitamin B12-binding protein and histaminase observed with PMA alone.	Tetradecanoylphorbol Acetate	0-3	glucuronidase beta	Homo sapiens	111-129
3624319-1	1987	We compared transferrin receptor (TfR) expression on human peripheral blood lymphocytes (PBL) activated by phorbol myristate acetate (PMA) or L-phytohemagglutinin (LPHA) using two techniques: (1) 125I-iron-saturated transferrin (FeTf) binding, (2) reactivity with monoclonal anti-TfR antibodies--OKT9 and B3/25.	Tetradecanoylphorbol Acetate	134-137	transferrin receptor	Homo sapiens	12-32
6430792-5	1984	PMA activation in the presence of cytochalasin B augments the release of lysozyme and initiates the release of beta glucuronidase through recruitment of the azurophilic granule but has no incremental effect on the release of vitamin B12-binding protein and histaminase observed with PMA alone.	Tetradecanoylphorbol Acetate	0-3	amine oxidase copper containing 1	Homo sapiens	257-268
3121993-10	1987	In contrast to the stimulatory effect of A23187, the PMA-induced liberation of neutrophil elastase was attenuated, but not completely abolished, by complexation of extracellular calcium with EDTA.	Tetradecanoylphorbol Acetate	53-56	elastase, neutrophil expressed	Homo sapiens	79-98
3624319-1	1987	We compared transferrin receptor (TfR) expression on human peripheral blood lymphocytes (PBL) activated by phorbol myristate acetate (PMA) or L-phytohemagglutinin (LPHA) using two techniques: (1) 125I-iron-saturated transferrin (FeTf) binding, (2) reactivity with monoclonal anti-TfR antibodies--OKT9 and B3/25.	Tetradecanoylphorbol Acetate	134-137	transferrin receptor	Homo sapiens	34-37
3121993-11	1987	Both 10(-4) M verapamil (-43%) and 10(-5) M trifluoperazine (-42%) were able to reduce the PMA-induced release of neutrophil elastase.	Tetradecanoylphorbol Acetate	91-94	elastase, neutrophil expressed	Homo sapiens	114-133
6436129-2	1984	Both TPA and teleocidin B caused a marked increase in the synthesis of two polypeptides with molecular weights of 44 kilodaltons (p44) and 55 kilodaltons (p55).	Tetradecanoylphorbol Acetate	5-8	interferon induced protein 44	Homo sapiens	130-133
3106355-1	1987	Phorbol 12-myristate 13-acetate (PMA) was used to examine the role of insulin receptor phosphorylation in the regulation of insulin receptor internalization in vascular endothelial cells.	Tetradecanoylphorbol Acetate	0-31	insulin receptor	Rattus norvegicus	124-140
6330200-2	1984	We investigated whether cultured acute lymphocytic leukemic T cell lines can be induced to differentiate and express the Tac antigen, a cell surface protein that contains a TCGF-binding site, after exposure to phorbol 12-myristate 13-acetate (PMA) and/or phytohemagglutinin (PHA).	Tetradecanoylphorbol Acetate	210-241	interleukin 2 receptor subunit alpha	Homo sapiens	121-132
3099788-4	1986	TPA elicits similar neopterin and biopterin accumulation kinetics in cell lines such as HL-60, Reh, Jurkat JMN, HeLa and 293, whereby HL-60 and Reh release substantial amounts of these transiently formed pteridines into the medium.	Tetradecanoylphorbol Acetate	0-3	carboxylesterase 1	Homo sapiens	95-98
3099788-4	1986	TPA elicits similar neopterin and biopterin accumulation kinetics in cell lines such as HL-60, Reh, Jurkat JMN, HeLa and 293, whereby HL-60 and Reh release substantial amounts of these transiently formed pteridines into the medium.	Tetradecanoylphorbol Acetate	0-3	carboxylesterase 1	Homo sapiens	144-147
3106355-9	1987	When surfaced-labeled cells were preincubated with PMA at 37 degrees C, the rate of insulin receptor internalization was increased by 3.6 +/- 0.2-fold and 2.1 +/- 0.5-fold at 1 and 5 min of insulin exposure, respectively (ED50 at 16 nM PMA).	Tetradecanoylphorbol Acetate	51-54	insulin receptor	Rattus norvegicus	84-100
3106355-9	1987	When surfaced-labeled cells were preincubated with PMA at 37 degrees C, the rate of insulin receptor internalization was increased by 3.6 +/- 0.2-fold and 2.1 +/- 0.5-fold at 1 and 5 min of insulin exposure, respectively (ED50 at 16 nM PMA).	Tetradecanoylphorbol Acetate	236-239	insulin receptor	Rattus norvegicus	84-100
3100060-6	1986	Il-1 required the simultaneous presence of ionomycin and TPA to have any demonstrable effect on T lymphocytes from spleen and on thymocytes.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 complex	Mus musculus	0-4
6420182-1	1984	3",5"-Dichloro-2,4"-dihydroxybenzanilide, an inhibitor of histidine decarboxylase, inhibited skin tumor promotion induced by 12-O-tetradecanoylphorbol-13-acetate in mice.	Tetradecanoylphorbol Acetate	125-161	histidine decarboxylase	Mus musculus	58-81
2881980-11	1987	However, in cells treated with either PMA or forskolin, there is an increase in the phosphorylation of only one of these peptides derived from tyrosine hydroxylase.	Tetradecanoylphorbol Acetate	38-41	tyrosine hydroxylase	Rattus norvegicus	143-163
3100060-7	1986	However, on EL4 cells which were also partially responsive to TPA alone, Il-1 showed strong synergy with TPA to induce Il-2 secretion and Il-2 receptor expression.	Tetradecanoylphorbol Acetate	62-65	interleukin 1 complex	Mus musculus	73-77
3100060-8	1986	The effect of Il-1 on EL4 cells was dose dependent where increasingly higher concentrations of Il-1 in the presence of a fixed concentration of TPA caused higher percentage of EL4 cells to become Il-2 receptor positive.	Tetradecanoylphorbol Acetate	144-147	interleukin 1 complex	Mus musculus	14-18
3100060-8	1986	The effect of Il-1 on EL4 cells was dose dependent where increasingly higher concentrations of Il-1 in the presence of a fixed concentration of TPA caused higher percentage of EL4 cells to become Il-2 receptor positive.	Tetradecanoylphorbol Acetate	144-147	interleukin 1 complex	Mus musculus	95-99
6315213-2	1983	Application of glycyrrhetinic acid or steviol to mouse skin 1 h before TPA treatment showed a remarkable decrease in TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	117-120	POU domain, class 3, transcription factor 3	Mus musculus	55-61
2881980-14	1987	These results indicate that tyrosine hydroxylase is activated and phosphorylated on different sites in PC12 cells exposed to PMA and forskolin and that phosphorylation of either of these sites is associated with activation of tyrosine hydroxylase.	Tetradecanoylphorbol Acetate	125-128	tyrosine hydroxylase	Rattus norvegicus	28-48
6345005-1	1983	Migration-inhibitory-factor (MIF) activity was detected in culture supernatants of the human T-lymphoblast cell line Mo after stimulation with phytohemagglutinin and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	166-191	macrophage migration inhibitory factor	Homo sapiens	0-27
2881980-14	1987	These results indicate that tyrosine hydroxylase is activated and phosphorylated on different sites in PC12 cells exposed to PMA and forskolin and that phosphorylation of either of these sites is associated with activation of tyrosine hydroxylase.	Tetradecanoylphorbol Acetate	125-128	tyrosine hydroxylase	Rattus norvegicus	226-246
6345005-1	1983	Migration-inhibitory-factor (MIF) activity was detected in culture supernatants of the human T-lymphoblast cell line Mo after stimulation with phytohemagglutinin and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	166-191	macrophage migration inhibitory factor	Homo sapiens	29-32
6345005-2	1983	MIF activity was not detected in unstimulated cultures reconstituted with phytohemagglutinin and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	97-122	macrophage migration inhibitory factor	Homo sapiens	0-3
3033212-2	1987	PMA, but not 4 alpha-phorbol, suppressed muscarinic receptor-mediated cyclic GMP responses in a time-dependent and a concentration-dependent fashion with an IC50 of 68.8 +/- 20.2 nM.	Tetradecanoylphorbol Acetate	0-3	5'-nucleotidase, cytosolic II	Mus musculus	77-80
3533575-8	1986	These findings make a contrast to those reported in fibroblasts, and may be linked to the characteristic response of cultured human keratinocytes to TPA in the proliferation of cells and induction of ornithine decarboxylase.	Tetradecanoylphorbol Acetate	149-152	ornithine decarboxylase 1	Homo sapiens	200-223
3033212-3	1987	The inhibitory effects of PMA on CBC-induced cyclic GMP formation were of a mixed competitive and noncompetitive type, being characterized by a depression of maximal cyclic GMP response to CBC and a significant increase in its EC50.	Tetradecanoylphorbol Acetate	26-29	5'-nucleotidase, cytosolic II	Mus musculus	52-55
3033212-3	1987	The inhibitory effects of PMA on CBC-induced cyclic GMP formation were of a mixed competitive and noncompetitive type, being characterized by a depression of maximal cyclic GMP response to CBC and a significant increase in its EC50.	Tetradecanoylphorbol Acetate	26-29	5'-nucleotidase, cytosolic II	Mus musculus	173-176
3023484-10	1986	Although calcium ionophore (2 X 10(-6) M) caused enzyme release (24.2% release of beta-glucuronidase, 29.4% release of arylsulfatase), this release was inhibited by the addition of TPA.	Tetradecanoylphorbol Acetate	181-184	glucuronidase beta	Homo sapiens	82-100
6828143-4	1983	We now show that treatment of parietal yolk sacs (PYS-2) cells with biologically active 12-O-tetradecanoyl phorbol-13-acetate (TPA) provokes a rapid decrease in cytosolic Ca, PL-PK activity that is accompanied by a significant increase in the amount of Ca, PL-PK activity associated with the plasma membrane fraction.	Tetradecanoylphorbol Acetate	88-125	interleukin-1 receptor-associated kinase 1	Mus musculus	175-180
3033212-4	1987	PMA also significantly reduced [3H]cyclic GMP formation induced by histamine, without affecting the responses elicited either by sodium azide or the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	0-3	5'-nucleotidase, cytosolic II	Mus musculus	42-45
6828143-4	1983	We now show that treatment of parietal yolk sacs (PYS-2) cells with biologically active 12-O-tetradecanoyl phorbol-13-acetate (TPA) provokes a rapid decrease in cytosolic Ca, PL-PK activity that is accompanied by a significant increase in the amount of Ca, PL-PK activity associated with the plasma membrane fraction.	Tetradecanoylphorbol Acetate	88-125	interleukin-1 receptor-associated kinase 1	Mus musculus	257-262
6828143-4	1983	We now show that treatment of parietal yolk sacs (PYS-2) cells with biologically active 12-O-tetradecanoyl phorbol-13-acetate (TPA) provokes a rapid decrease in cytosolic Ca, PL-PK activity that is accompanied by a significant increase in the amount of Ca, PL-PK activity associated with the plasma membrane fraction.	Tetradecanoylphorbol Acetate	127-130	interleukin-1 receptor-associated kinase 1	Mus musculus	175-180
6828143-4	1983	We now show that treatment of parietal yolk sacs (PYS-2) cells with biologically active 12-O-tetradecanoyl phorbol-13-acetate (TPA) provokes a rapid decrease in cytosolic Ca, PL-PK activity that is accompanied by a significant increase in the amount of Ca, PL-PK activity associated with the plasma membrane fraction.	Tetradecanoylphorbol Acetate	127-130	interleukin-1 receptor-associated kinase 1	Mus musculus	257-262
3103602-8	1986	TPA did not impede cyclic AMP generation in response to FSH, cholera toxin or forskolin acutely (within 48 h), but did inhibit the stimulatory effects of 8-bromo cyclic AMP, insulin and oestradiol on progesterone biosynthesis.	Tetradecanoylphorbol Acetate	0-3	insulin	Sus scrofa	174-181
3033212-5	1987	Although the inhibitory effects of PMA on CBC-induced cyclic GMP formation were not reversed by washing, these effects were significantly attenuated by H-7 [1-(5-isoquinolinesulfonyl)-2-methylpiperazine], a protein kinase C inhibitor.	Tetradecanoylphorbol Acetate	35-38	5'-nucleotidase, cytosolic II	Mus musculus	61-64
3033212-7	1987	On the other hand, PMA competed for the specific binding of a labeled phorbol ester in intact cells with a potency similar to that of PMA in inhibiting muscarinic receptor-mediated [3H]cyclic GMP responses.	Tetradecanoylphorbol Acetate	19-22	5'-nucleotidase, cytosolic II	Mus musculus	192-195
3030703-2	1987	Both cholera toxin (CT), which activates adenylate cyclase, and 12-O-tetradecanoyl phorbol-13-acetate (TPA), a protein kinase C activator, stimulated the secretion of hCG in a dose-dependent manner.	Tetradecanoylphorbol Acetate	64-101	hypertrichosis 2 (generalised, congenital)	Homo sapiens	167-170
2428876-4	1986	Phorbol myristate acetate (PMA) stimulation of B chronic lymphocytic leukemia cells dramatically increased p150,95 expression.	Tetradecanoylphorbol Acetate	0-25	chromatin assembly factor 1 subunit A	Homo sapiens	107-111
2428876-4	1986	Phorbol myristate acetate (PMA) stimulation of B chronic lymphocytic leukemia cells dramatically increased p150,95 expression.	Tetradecanoylphorbol Acetate	27-30	chromatin assembly factor 1 subunit A	Homo sapiens	107-111
2948494-3	1986	With increasing times of incubation with PMA (10 s-5 min), the rise in [Ca2+]i induced by thrombin and the TxA2 mimetic, U46619, was increasingly inhibited (90-100% with 5 min incubation) and, correlating with this, thrombin-induced [3H]arachidonate, TxB2 and beta-thromboglobulin (beta TG) release were also inhibited.	Tetradecanoylphorbol Acetate	41-44	pro-platelet basic protein	Homo sapiens	282-289
6404261-1	1983	Lecanoric acid analogues containing benzanilide structure inhibited histidine decarboxylase and arachidonic acid release from the cell membrane phospholipids induced by a tumour promoter, 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	188-224	histidine decarboxylase	Mus musculus	68-91
6604057-2	1983	12-O-Tetradecanoylphorbol-13-acetate (TPA) enhanced cell proliferation of SCC-1 cells in suspension culture.	Tetradecanoylphorbol Acetate	0-36	protein tyrosine phosphatase receptor type J	Homo sapiens	74-79
6604057-2	1983	12-O-Tetradecanoylphorbol-13-acetate (TPA) enhanced cell proliferation of SCC-1 cells in suspension culture.	Tetradecanoylphorbol Acetate	38-41	protein tyrosine phosphatase receptor type J	Homo sapiens	74-79
2948494-7	1986	The results indicate that, while PMA may cause an inhibition of agonist-induced [Ca2+]i mobilization resulting in an inhibition of agonist-induced arachidonate, TxB2 and beta TG release, its effects on agonist-induced 5HT secretion may be complicated by [Ca2+]i-independent synergistic effects of agonist and PMA.	Tetradecanoylphorbol Acetate	33-36	pro-platelet basic protein	Homo sapiens	170-177
3030703-2	1987	Both cholera toxin (CT), which activates adenylate cyclase, and 12-O-tetradecanoyl phorbol-13-acetate (TPA), a protein kinase C activator, stimulated the secretion of hCG in a dose-dependent manner.	Tetradecanoylphorbol Acetate	103-106	hypertrichosis 2 (generalised, congenital)	Homo sapiens	167-170
6751097-8	1982	TPA perturbs the insulin receptor of cultured human lymphocytes in a fashion similar to its effect on the epidermal growth factor receptor of several other cell types.	Tetradecanoylphorbol Acetate	0-3	insulin receptor	Homo sapiens	17-33
6949641-8	1982	Sixty to 70% of the TPA-treated THP-1-O and THP-1-R cells were able to phagocytize yeasts and immunoglobulin G-coated sheep erythrocytes.	Tetradecanoylphorbol Acetate	20-23	Thp1p	Saccharomyces cerevisiae S288C	44-49
3030703-4	1987	When added together, TPA potentiated the effect of CT on hCG secretion (from 16- to 27-fold) and cAMP accumulation (from 36- to 54-fold) in the medium.	Tetradecanoylphorbol Acetate	21-24	hypertrichosis 2 (generalised, congenital)	Homo sapiens	57-60
3030703-5	1987	TPA (1.0 ng/ml) also caused a 2.0-fold increase in basal cAMP production after 72 h. Time-course studies indicated that the effect of TPA on CT-induced cAMP and hCG productions became significant at 45 min and 6 h, respectively, from the beginning of stimulation.	Tetradecanoylphorbol Acetate	0-3	hypertrichosis 2 (generalised, congenital)	Homo sapiens	161-164
3030703-5	1987	TPA (1.0 ng/ml) also caused a 2.0-fold increase in basal cAMP production after 72 h. Time-course studies indicated that the effect of TPA on CT-induced cAMP and hCG productions became significant at 45 min and 6 h, respectively, from the beginning of stimulation.	Tetradecanoylphorbol Acetate	134-137	hypertrichosis 2 (generalised, congenital)	Homo sapiens	161-164
3030703-7	1987	Our results demonstrate that TPA potentiates CT-induced cAMP and hCG production in cultured human choriocarcinoma cells.	Tetradecanoylphorbol Acetate	29-32	hypertrichosis 2 (generalised, congenital)	Homo sapiens	65-68
6947829-4	1982	It was found that after 3 days of TPA treatment, HL-60 cells released PAF following phagocytosis of C3b- and C3d-opsonized yeast spores.	Tetradecanoylphorbol Acetate	34-37	endogenous retrovirus group K member 3	Homo sapiens	100-103
3090144-5	1986	In the presence of either suboptimal levels of phorbol ester (PMA) or Ionomycin, the addition of IL 1 resulted in up to an 80-fold enhancement in the amount of IL 2 secreted.	Tetradecanoylphorbol Acetate	62-65	interleukin 1 complex	Mus musculus	97-101
2821027-7	1987	TPA stimulated cell proliferation slightly but, in contrast to cholera toxin, increased cell rounding and the secretion of neutral proteinase and plasminogen activator.	Tetradecanoylphorbol Acetate	0-3	endogenous retrovirus group K member 21, envelope	Homo sapiens	131-141
2941417-6	1986	These results also provide direct evidence that the in vivo phosphorylation of the IL-2 receptor stimulated by TPA is catalyzed by protein kinase C. The sites phosphorylated in the HLA antigens in vitro by protein kinase C or in vivo after TPA stimulation were also localized to the carboxyl-terminal cytoplasmic domain of the heavy chain by limited proteolysis.	Tetradecanoylphorbol Acetate	111-114	interleukin 2 receptor subunit beta	Homo sapiens	83-96
2941417-6	1986	These results also provide direct evidence that the in vivo phosphorylation of the IL-2 receptor stimulated by TPA is catalyzed by protein kinase C. The sites phosphorylated in the HLA antigens in vitro by protein kinase C or in vivo after TPA stimulation were also localized to the carboxyl-terminal cytoplasmic domain of the heavy chain by limited proteolysis.	Tetradecanoylphorbol Acetate	240-243	interleukin 2 receptor subunit beta	Homo sapiens	83-96
6252258-3	1980	Release of histaminase induced by aggregated IgG, phorbal myristate acetate (PMA), formyl-methionyl-leucyl-phenylalanine (FMLP) and calcium ionophore was not affected by IAA.	Tetradecanoylphorbol Acetate	77-80	amine oxidase copper containing 1	Homo sapiens	11-22
3028794-5	1987	The inhibitory effects of PMA on hCG stimulation of both cAMP and testosterone were due mainly to a decrease of the Vmax without modification of the ED50.	Tetradecanoylphorbol Acetate	26-29	hypertrichosis 2 (generalised, congenital)	Homo sapiens	33-36
6155996-0	1980	Enhancement by 3-isobutyl-1-methylxanthine and cholera toxin of 12-O-tetradecanoylphorbol-13-acetate-stimulated cyclic nucleotide levels and ornithine decarboxylase activity in isolated epidermal cells.	Tetradecanoylphorbol Acetate	64-100	ornithine decarboxylase 1	Homo sapiens	141-164
3087969-6	1986	The pHi increases generated by ConA or TPA are not necessary for expression of mRNA from either gene in response to these mitogens.	Tetradecanoylphorbol Acetate	39-42	glucose-6-phosphate isomerase 1	Mus musculus	4-7
3011802-7	1986	Thyrotropin-releasing hormone (TRH) and guanosine 5"-Q-thiotriphosphate, which stimulate polyphosphoinositide breakdown in permeable cells, were found to be only weak stimulators of PRL release, compared to TPA and exogenous diacylglycerol.	Tetradecanoylphorbol Acetate	207-210	thyrotropin releasing hormone	Rattus norvegicus	0-29
3011802-9	1986	PRL release from TRH-pretreated permeable cells resembled TPA- and OAG-stimulated secretion, with [Ca2+] greater than 0.1 microM potentiating the effect of TRH pretreatment.	Tetradecanoylphorbol Acetate	58-61	thyrotropin releasing hormone	Rattus norvegicus	17-20
3028794-8	1987	The effects of PMA were dose- and time-dependent; however, the concentration of PMA required to induce half-maximal effects on hCG receptors (10 nM) was about one order of magnitude higher than those required to reduce cAMP and testosterone productions.	Tetradecanoylphorbol Acetate	15-18	hypertrichosis 2 (generalised, congenital)	Homo sapiens	127-130
6967316-0	1980	Retinoids block ornithine decarboxylase induction in cells treated with the tumor promotor TPA or the peptide growth hormones, EGF and SGF.	Tetradecanoylphorbol Acetate	91-94	ornithine decarboxylase 1	Homo sapiens	16-39
3028794-9	1987	Further, the inhibitory effects on cAMP and testosterone secretions appeared within the first 3 h, whereas the hCG receptor number remained constant for at least 8 h. It appears therefore, that the main alteration responsible for the steroidogenic refractoriness of PMA-treated Leydig cells is located beyond cAMP formation.	Tetradecanoylphorbol Acetate	266-269	hypertrichosis 2 (generalised, congenital)	Homo sapiens	111-114
2438271-5	1987	Parathyroid hormone (PTH) and dibutyryl cyclic AMP reversed the morphological and histochemical changes caused by a 4-day treatment with teleocidin or aplysiatoxin as well as with TPA, reversal being apparent after 2 days.	Tetradecanoylphorbol Acetate	180-183	parathyroid hormone	Oryctolagus cuniculus	0-19
316362-1	1979	Previous studies indicated that the potent tumor promoter 12--0--tetradecanoyl-phorbol-13-acetate (TPA) enhances transformation of rat embryo cells (2 degrees RE) by a mutant of human Ad5 (H5ts125).	Tetradecanoylphorbol Acetate	99-102	Alzheimer disease, familial, type 5	Homo sapiens	184-187
3082877-2	1986	The recombinant IL-2 receptor in these cells was rapidly phosphorylated in response to phorbol myristate acetate (PMA), but its phosphorylation could not be detected in the absence of PMA or upon addition of human IL-2.	Tetradecanoylphorbol Acetate	87-112	interleukin 2 receptor subunit beta	Homo sapiens	16-29
3082877-2	1986	The recombinant IL-2 receptor in these cells was rapidly phosphorylated in response to phorbol myristate acetate (PMA), but its phosphorylation could not be detected in the absence of PMA or upon addition of human IL-2.	Tetradecanoylphorbol Acetate	114-117	interleukin 2 receptor subunit beta	Homo sapiens	16-29
3082877-2	1986	The recombinant IL-2 receptor in these cells was rapidly phosphorylated in response to phorbol myristate acetate (PMA), but its phosphorylation could not be detected in the absence of PMA or upon addition of human IL-2.	Tetradecanoylphorbol Acetate	184-187	interleukin 2 receptor subunit beta	Homo sapiens	16-29
2438271-5	1987	Parathyroid hormone (PTH) and dibutyryl cyclic AMP reversed the morphological and histochemical changes caused by a 4-day treatment with teleocidin or aplysiatoxin as well as with TPA, reversal being apparent after 2 days.	Tetradecanoylphorbol Acetate	180-183	parathyroid hormone	Oryctolagus cuniculus	21-24
476628-7	1979	TPA also inhibited this alpha-melanocyte-stimulating hormone-induced melanogenesis.	Tetradecanoylphorbol Acetate	0-3	pro-opiomelanocortin-alpha	Mus musculus	24-60
2438271-6	1987	PTH increased intracellular cyclic AMP after 2 min in chondrocytes pretreated with teleocidin or aplysiatoxin as well as with TPA.	Tetradecanoylphorbol Acetate	126-129	parathyroid hormone	Oryctolagus cuniculus	0-3
2438271-7	1987	PTH also increased ornithine decarboxylase [ODC; EC 4.1.1.17] activity in these chondrocytes after 4 h. These results show that retention of responsiveness to PTH is a typical characteristic of chondrocytes dedifferentiated by treatment with TPA-type tumor promoters such as TPA, teleocidin and aplysiatoxin.	Tetradecanoylphorbol Acetate	242-245	parathyroid hormone	Oryctolagus cuniculus	0-3
3513185-2	1986	Stimulation of neutrophils with low concentrations of phorbol 12-myristate 13-acetate (PMA) results in the release into the medium of the membrane-bound proteinase and the concomitant production of oxygen radicals.	Tetradecanoylphorbol Acetate	54-85	endogenous retrovirus group K member 18	Homo sapiens	153-163
2438271-7	1987	PTH also increased ornithine decarboxylase [ODC; EC 4.1.1.17] activity in these chondrocytes after 4 h. These results show that retention of responsiveness to PTH is a typical characteristic of chondrocytes dedifferentiated by treatment with TPA-type tumor promoters such as TPA, teleocidin and aplysiatoxin.	Tetradecanoylphorbol Acetate	242-245	parathyroid hormone	Oryctolagus cuniculus	159-162
3513185-2	1986	Stimulation of neutrophils with low concentrations of phorbol 12-myristate 13-acetate (PMA) results in the release into the medium of the membrane-bound proteinase and the concomitant production of oxygen radicals.	Tetradecanoylphorbol Acetate	87-90	endogenous retrovirus group K member 18	Homo sapiens	153-163
231407-0	1979	Intracellular mediation of lymphokine action: mimicry of migration inhibitory factor (MIF) action by phorbol myristate acetate (PMA) and the ionophore A23187.	Tetradecanoylphorbol Acetate	101-126	macrophage migration inhibitory factor	Homo sapiens	57-84
231407-0	1979	Intracellular mediation of lymphokine action: mimicry of migration inhibitory factor (MIF) action by phorbol myristate acetate (PMA) and the ionophore A23187.	Tetradecanoylphorbol Acetate	101-126	macrophage migration inhibitory factor	Homo sapiens	86-89
2438271-7	1987	PTH also increased ornithine decarboxylase [ODC; EC 4.1.1.17] activity in these chondrocytes after 4 h. These results show that retention of responsiveness to PTH is a typical characteristic of chondrocytes dedifferentiated by treatment with TPA-type tumor promoters such as TPA, teleocidin and aplysiatoxin.	Tetradecanoylphorbol Acetate	275-278	parathyroid hormone	Oryctolagus cuniculus	0-3
231407-0	1979	Intracellular mediation of lymphokine action: mimicry of migration inhibitory factor (MIF) action by phorbol myristate acetate (PMA) and the ionophore A23187.	Tetradecanoylphorbol Acetate	128-131	macrophage migration inhibitory factor	Homo sapiens	57-84
231407-0	1979	Intracellular mediation of lymphokine action: mimicry of migration inhibitory factor (MIF) action by phorbol myristate acetate (PMA) and the ionophore A23187.	Tetradecanoylphorbol Acetate	128-131	macrophage migration inhibitory factor	Homo sapiens	86-89
3007165-4	1986	These studies show that TPA at a final concentration of 5 ng/ml greatly increased Tac antigen expression on a number of sublines of B17.	Tetradecanoylphorbol Acetate	24-27	interleukin 2 receptor subunit alpha	Homo sapiens	82-93
2438271-7	1987	PTH also increased ornithine decarboxylase [ODC; EC 4.1.1.17] activity in these chondrocytes after 4 h. These results show that retention of responsiveness to PTH is a typical characteristic of chondrocytes dedifferentiated by treatment with TPA-type tumor promoters such as TPA, teleocidin and aplysiatoxin.	Tetradecanoylphorbol Acetate	275-278	parathyroid hormone	Oryctolagus cuniculus	159-162
3492534-3	1987	A monoclonal anti-Bp50 antibody could augment the proliferation of B cells activated by anti-IgM, anti-CD20, or 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulation, but was not co-stimulatory with B cell growth factor (BCGF), interleukin 1, or interleukin 2.	Tetradecanoylphorbol Acetate	112-149	BP50	Homo sapiens	18-22
3512424-6	1986	HLA-DP and -DQ antigens were expressed on greater than 90% of the cells in all cases studied after culture of the cells with TPA, and MHC class II specific mRNA transcripts were correspondingly increased.	Tetradecanoylphorbol Acetate	125-128	major histocompatibility complex, class II, DP beta 1	Homo sapiens	0-14
728885-0	1978	Stimulation of the synthesis of the H1 and H3 histone fractions of mouse epidermis by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	86-122	histocompatibility 1	Mus musculus	36-44
3492534-3	1987	A monoclonal anti-Bp50 antibody could augment the proliferation of B cells activated by anti-IgM, anti-CD20, or 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulation, but was not co-stimulatory with B cell growth factor (BCGF), interleukin 1, or interleukin 2.	Tetradecanoylphorbol Acetate	151-154	BP50	Homo sapiens	18-22
3492534-8	1987	Bp50 was found to have several properties in common with HLA class II molecules: both Bp50 and class II were expressed at lower levels on blood B cells than on tonsillar B cells; the expression of both Bp50 and class II was increased after activation of blood B cells with TPA or anti-IgM; and the expression of both Bp50 and class II was increased after activation of non T, non-B acute leukemias with BCGF.	Tetradecanoylphorbol Acetate	273-276	BP50	Homo sapiens	0-4
3006036-4	1986	In addition, progesterone receptor levels are decreased after TPA treatment in the hormone-dependent cell lines MCF-7, T-47-D, and ZR-75-1, whereas the estrogen receptor levels remained unchanged.	Tetradecanoylphorbol Acetate	62-65	progesterone receptor	Homo sapiens	13-34
1158973-4	1975	Beta-glucuronidase was not released in significant amounts from PMN"s exposed to PMA alone, in the absence of stimuli such as zymosan or C5a.	Tetradecanoylphorbol Acetate	81-84	glucuronidase beta	Homo sapiens	0-18
3121190-2	1987	Disappearance of vinculin staining from adhesion plaques is also caused by 12-O-tetradecanoyl-phorbol-13-acetate (TPA; 200-400 nM), though the time course of the disappearance of vinculin staining under these conditions takes longer than in cells exposed to PDGF.	Tetradecanoylphorbol Acetate	75-112	vinculin	Homo sapiens	17-25
1158973-7	1975	Enhancement of lysosomal enzyme (beta-glucuronidase) release by PMA appears to be independent of effects on release of specific granule enzymes (lysozyme), but rather is likely due to PMA-induced elevations of cellular cGMP.	Tetradecanoylphorbol Acetate	64-67	glucuronidase beta	Homo sapiens	33-51
1158973-7	1975	Enhancement of lysosomal enzyme (beta-glucuronidase) release by PMA appears to be independent of effects on release of specific granule enzymes (lysozyme), but rather is likely due to PMA-induced elevations of cellular cGMP.	Tetradecanoylphorbol Acetate	184-187	glucuronidase beta	Homo sapiens	33-51
3762216-5	1986	Phosphorylation of various cell lysate proteins (p18, p21, p29, p34 and p45) were also stimulated by TPA.	Tetradecanoylphorbol Acetate	101-104	nuclear factor, erythroid derived 2	Mus musculus	72-75
3121190-2	1987	Disappearance of vinculin staining from adhesion plaques is also caused by 12-O-tetradecanoyl-phorbol-13-acetate (TPA; 200-400 nM), though the time course of the disappearance of vinculin staining under these conditions takes longer than in cells exposed to PDGF.	Tetradecanoylphorbol Acetate	114-117	vinculin	Homo sapiens	17-25
3930604-2	1985	In the rat liver cells that had been prelabeled with [3H]arachidonic acid, the release of 6-keto-PGF1 alpha and arachidonic acid also was stimulated by the IL 1, and this release was synergistic in the presence of TPA.	Tetradecanoylphorbol Acetate	214-217	interleukin 1 complex	Mus musculus	156-160
33676894-6	2021	Kv1.5, but not Kv1.1, Kv1.2, Kv1.3 or Kv1.4, was uniquely sensitive to PMA treatment.	Tetradecanoylphorbol Acetate	71-74	potassium voltage-gated channel subfamily A member 3	Homo sapiens	29-34
3121190-8	1987	Both PDGF (20 ng/ml) and TPA (100 nM) caused cytosolic alkalinization which occurred after PDGF-induced disruption of vinculin from adhesion plaques, as determined using the pH-sensitive indicator BCECF and Digitized Video Microscopy.	Tetradecanoylphorbol Acetate	25-28	vinculin	Homo sapiens	118-126
3465727-3	1986	Bryostatins 1 and 2 (B1 and B2, respectively) competed for [3H]phorbol 12,13-dibutyrate binding to the protein kinase C complex in intact cells nearly equipotently with TPA.	Tetradecanoylphorbol Acetate	169-172	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	0-30
33129947-12	2021	In an in vitro study, CJT pretreatment suppressed the LPS-induced TNF-alpha secretion in RAW264.7 cells and attenuated the PMA-induced IL-6, IL-8 and MCP-1 secretion in A549 cells.	Tetradecanoylphorbol Acetate	123-126	chemokine (C-X-C motif) ligand 15	Mus musculus	141-145
3465727-7	1986	However, B1 and B2 were only partial agonists because they enhanced prolactin synthesis to a lesser maximal extent than did TPA and, given in combination, they reduced TPA-enhanced prolactin synthesis.	Tetradecanoylphorbol Acetate	168-171	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	9-18
3161611-10	1985	On the other hand, TPA-treated cells exhibited a characteristic pp130 which was antigenically related to the actin binding protein, vinculin.	Tetradecanoylphorbol Acetate	19-22	vinculin	Homo sapiens	132-140
3026433-2	1986	After in-vitro stimulation with various agents including TPA, gamma interferon and colony stimulating factor, the purified blast cells of all cases of AML tested (10 of 10) showed high levels (50-90% cells positive) of IL-2R expression.	Tetradecanoylphorbol Acetate	57-60	interleukin 2 receptor subunit alpha	Homo sapiens	219-224
33333171-4	2021	Interestingly, this fatty acid increased plasma membrane expression of TRPC6 after 24 h of mitogenic stimulation by phorbol-13-myristate-12-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	149-152	transient receptor potential cation channel subfamily C member 6	Homo sapiens	71-76
33307168-4	2021	In this study, we found mtROS generation and phosphorylation of MAPKs were mediated by PKCdelta in HCCs treated with the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	136-173	protein kinase C delta	Homo sapiens	87-95
33307168-4	2021	In this study, we found mtROS generation and phosphorylation of MAPKs were mediated by PKCdelta in HCCs treated with the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	175-178	protein kinase C delta	Homo sapiens	87-95
33307168-9	2021	Moreover, TPA induced opposite phenotypical changes of HCCs, G1 cell cycle arrest, and cell migration, which were prevented by mtROS scavengers and depletion of PKCdelta and HSP60.	Tetradecanoylphorbol Acetate	10-13	protein kinase C delta	Homo sapiens	161-169
3533683-11	1986	The ability of diacylglycerol to mimic the effects of TPA on the insulin receptor supports the concept of diacylglycerols as endogenous phorbol diester analogues even though the sole role of protein kinase C in our system is doubtful.	Tetradecanoylphorbol Acetate	54-57	insulin receptor	Homo sapiens	65-81
33307168-10	2021	Consistently, TPA increased the migration-related genes, hydrogen peroxide inducible clone5, matrix metalloproteinase-1/3, laminingamma2, and suppressed the cell cycle regulator cyclin E1 (CCNE1) via PKCdelta/mtROS/HSP60/MAPK-axis.	Tetradecanoylphorbol Acetate	14-17	protein kinase C delta	Homo sapiens	200-208
33128580-3	2021	Mechanistic investigation revealed that transforming growth factor beta-induced (TGFBI) acts as a potential downstream target of HMGB1 and lentivirus-mediated knockdown of TGFBI expression impaired phorbol-12-myristate-13-acetate (PMA) and all-trans retinoic acid (ATRA)-induced myeloid differentiation of AML cell lines.	Tetradecanoylphorbol Acetate	198-229	high mobility group box 1	Homo sapiens	129-134
33128580-3	2021	Mechanistic investigation revealed that transforming growth factor beta-induced (TGFBI) acts as a potential downstream target of HMGB1 and lentivirus-mediated knockdown of TGFBI expression impaired phorbol-12-myristate-13-acetate (PMA) and all-trans retinoic acid (ATRA)-induced myeloid differentiation of AML cell lines.	Tetradecanoylphorbol Acetate	231-234	high mobility group box 1	Homo sapiens	129-134
2932340-0	1985	Modulation of complement receptors of a human monocyte cell line, U-937, during incubation with phorbol myristate acetate: expression of an iC3b-specific receptor (CR3).	Tetradecanoylphorbol Acetate	96-121	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	164-167
3930277-2	1985	We show here that differentiation induction (with either sodium butyrate, 12-O-tetradecanoyl-phorbol-13-acetate, or teleocidin) or recombinant alpha- or gamma-interferon (IFN) treatment resulted in the augmentation of HLA class-I antigen expression.	Tetradecanoylphorbol Acetate	74-111	MHC class I polypeptide-related sequence A	Homo sapiens	218-237
3537181-9	1986	Treatment of HL-60 cells with phorbol myristate acetate resulted in the appearance of Mac-1 and p150,95 on the cell surface.	Tetradecanoylphorbol Acetate	30-55	chromatin assembly factor 1 subunit A	Homo sapiens	96-100
3929255-6	1985	4 beta-Phorbol 12-myristate 13-acetate (PMA) also stimulates IL-2 receptor mRNA and protein expression by T cells.	Tetradecanoylphorbol Acetate	0-38	interleukin 2 receptor subunit beta	Homo sapiens	61-74
3929255-6	1985	4 beta-Phorbol 12-myristate 13-acetate (PMA) also stimulates IL-2 receptor mRNA and protein expression by T cells.	Tetradecanoylphorbol Acetate	40-43	interleukin 2 receptor subunit beta	Homo sapiens	61-74
3540948-1	1986	A polypeptide termed oncostatin M, which inhibits the replication of A375 melanoma and other human tumor cells, but not normal human fibroblasts, has been isolated from serum-free supernatants of U-937 histiocytic lymphoma cells that have been induced to differentiate into macrophage-like cells following treatment with the phorbol ester phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	339-370	oncostatin M	Homo sapiens	21-33
2996121-7	1985	TPA induced a redistribution of the TfR-pool to the intracellular space as demonstrated by morphology.	Tetradecanoylphorbol Acetate	0-3	transferrin receptor	Homo sapiens	36-39
32281291-11	2020	The correlation between RUNX1 and TGF-beta pathway was analyzed in the PMA-induced megakaryocytic differentiating K562 cells, which exhibit mature megakaryocytic features.	Tetradecanoylphorbol Acetate	71-74	transforming growth factor alpha	Homo sapiens	34-42
32468667-5	2020	The delta TPA values of TAT-(ZnP) 2 and TAT-(ZnP) 3 further increase to 1031 and up to 1496 GM respectively, indicating the effect of incorporated ZnP units on the TPA properties.	Tetradecanoylphorbol Acetate	164-167	tyrosine aminotransferase	Homo sapiens	24-27
2431900-1	1986	Expression of the myc and fos genes has been monitored in mouse primary keratinocytes after induction of terminal differentiation by calcium or tetradecanoylphorbol acetate (TPA).	Tetradecanoylphorbol Acetate	174-177	myelocytomatosis oncogene	Mus musculus	18-21
32468667-5	2020	The delta TPA values of TAT-(ZnP) 2 and TAT-(ZnP) 3 further increase to 1031 and up to 1496 GM respectively, indicating the effect of incorporated ZnP units on the TPA properties.	Tetradecanoylphorbol Acetate	164-167	tyrosine aminotransferase	Homo sapiens	40-43
3160693-8	1985	Concurrent (but not separate) addition of ionomycin and TPA also reconstituted a TRH-like burst of hormone secretion.	Tetradecanoylphorbol Acetate	56-59	thyrotropin releasing hormone	Rattus norvegicus	81-84
3160693-9	1985	These and previous results indicate that activation of protein kinase C by TPA or diacylglycerol (which is elevated by TRH) and a simultaneous spike in [Ca2+]i are required for burst secretion.	Tetradecanoylphorbol Acetate	75-78	thyrotropin releasing hormone	Rattus norvegicus	119-122
2431900-5	1986	In contrast to calcium, TPA-induced differentiation is accompanied by dramatic changes in proto-oncogene expression: marked c-fos induction and considerable although transient decrease in c-myc expression.	Tetradecanoylphorbol Acetate	24-27	myelocytomatosis oncogene	Mus musculus	190-193
3793878-6	1986	Addition of TPA caused no change in [Ca2+]i but a biphasic change in pHi.	Tetradecanoylphorbol Acetate	12-15	glucose-6-phosphate isomerase	Homo sapiens	69-72
3159731-8	1985	Treatment of GH4C1 cells with phorbol myristate acetate also resulted in a shift in protein kinase C distribution, although the response was slower than that produced by TRH.	Tetradecanoylphorbol Acetate	30-55	thyrotropin releasing hormone	Rattus norvegicus	170-173
33182035-4	2020	In phorbol 12-myristate 13-acetate (PMA)-stimulated A549 airway epithelial cells, THCA pretreatment decreased the mRNA expression and secretion of interleukin (IL)-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecules 1 (ICAM-1), and reduced the mRNA expression of matrix metalloproteinase 9 (MMP-9).	Tetradecanoylphorbol Acetate	36-39	chemokine (C-X-C motif) ligand 15	Mus musculus	147-165
33182035-4	2020	In phorbol 12-myristate 13-acetate (PMA)-stimulated A549 airway epithelial cells, THCA pretreatment decreased the mRNA expression and secretion of interleukin (IL)-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecules 1 (ICAM-1), and reduced the mRNA expression of matrix metalloproteinase 9 (MMP-9).	Tetradecanoylphorbol Acetate	36-39	intercellular adhesion molecule 1	Mus musculus	215-249
33182035-4	2020	In phorbol 12-myristate 13-acetate (PMA)-stimulated A549 airway epithelial cells, THCA pretreatment decreased the mRNA expression and secretion of interleukin (IL)-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecules 1 (ICAM-1), and reduced the mRNA expression of matrix metalloproteinase 9 (MMP-9).	Tetradecanoylphorbol Acetate	36-39	intercellular adhesion molecule 1	Mus musculus	251-257
33182035-4	2020	In phorbol 12-myristate 13-acetate (PMA)-stimulated A549 airway epithelial cells, THCA pretreatment decreased the mRNA expression and secretion of interleukin (IL)-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecules 1 (ICAM-1), and reduced the mRNA expression of matrix metalloproteinase 9 (MMP-9).	Tetradecanoylphorbol Acetate	36-39	matrix metallopeptidase 9	Mus musculus	295-321
33182035-4	2020	In phorbol 12-myristate 13-acetate (PMA)-stimulated A549 airway epithelial cells, THCA pretreatment decreased the mRNA expression and secretion of interleukin (IL)-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecules 1 (ICAM-1), and reduced the mRNA expression of matrix metalloproteinase 9 (MMP-9).	Tetradecanoylphorbol Acetate	36-39	matrix metallopeptidase 9	Mus musculus	323-328
2428504-2	1986	We demonstrate here that treatment of murine T cell hybridomas with phorbol 12-myristate 13-acetate results in phosphorylation of p25 and gp21 on serine residues.	Tetradecanoylphorbol Acetate	68-99	spermine binding protein	Mus musculus	130-133
32783140-4	2020	In this study, we demonstrated that treatment with phorbol 12-myristate 13-acetate (PMA, a PKC activator) for 6 h significantly increased ASIC1a protein expression and ASIC currents in NS20Y cells, a neuronal cell line, and in primary cultured mouse cortical neurons.	Tetradecanoylphorbol Acetate	51-82	acid-sensing (proton-gated) ion channel 1	Mus musculus	138-144
32783140-4	2020	In this study, we demonstrated that treatment with phorbol 12-myristate 13-acetate (PMA, a PKC activator) for 6 h significantly increased ASIC1a protein expression and ASIC currents in NS20Y cells, a neuronal cell line, and in primary cultured mouse cortical neurons.	Tetradecanoylphorbol Acetate	51-82	acid-sensing (proton-gated) ion channel 1	Mus musculus	138-142
2989273-3	1985	Exposing cells to 12-O-tetradecanoyl phorbol 13-acetate (TPA) also causes desensitization of the hCG response.	Tetradecanoylphorbol Acetate	18-55	chorionic gonadotropin subunit beta 5	Homo sapiens	97-100
2989273-3	1985	Exposing cells to 12-O-tetradecanoyl phorbol 13-acetate (TPA) also causes desensitization of the hCG response.	Tetradecanoylphorbol Acetate	57-60	chorionic gonadotropin subunit beta 5	Homo sapiens	97-100
3489045-4	1986	When treated with phorbol acetate (TPA), all three cell lines synthesize and express both HLA-DR and -DP molecules, indicating that the structural genes for these molecules remain intact.	Tetradecanoylphorbol Acetate	35-38	major histocompatibility complex, class II, DP beta 1	Homo sapiens	90-104
4006322-1	1985	We report here that the chemotactic peptide, N-formyl-methionyl-leucyl-phenylalanine (FMLP), and the mitogenic phorbol ester, phorbol myristate acetate (PMA) cause a time- and concentration-dependent, selective, extracellular release of N-acetyl-beta-glucosaminidase and lysozyme from freshly isolated, adherent human peripheral blood monocytes.	Tetradecanoylphorbol Acetate	153-156	O-GlcNAcase	Homo sapiens	237-266
32783140-4	2020	In this study, we demonstrated that treatment with phorbol 12-myristate 13-acetate (PMA, a PKC activator) for 6 h significantly increased ASIC1a protein expression and ASIC currents in NS20Y cells, a neuronal cell line, and in primary cultured mouse cortical neurons.	Tetradecanoylphorbol Acetate	84-87	acid-sensing (proton-gated) ion channel 1	Mus musculus	138-144
32783140-4	2020	In this study, we demonstrated that treatment with phorbol 12-myristate 13-acetate (PMA, a PKC activator) for 6 h significantly increased ASIC1a protein expression and ASIC currents in NS20Y cells, a neuronal cell line, and in primary cultured mouse cortical neurons.	Tetradecanoylphorbol Acetate	84-87	acid-sensing (proton-gated) ion channel 1	Mus musculus	138-142
3857122-1	1985	Two recently derived human myeloid leukemia cell lines, ML-1 and ML-2, were induced to differentiate by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) or with retinoic acid for 5 to 12 days.	Tetradecanoylphorbol Acetate	119-155	interleukin 17F	Homo sapiens	56-60
3017734-8	1986	Thus, calcium channel blockade effectively dissociates the effects of tetradecanoylphorbol acetate (TPA) on TFR internalization and phosphorylation.	Tetradecanoylphorbol Acetate	70-98	transferrin receptor	Homo sapiens	108-111
3857122-3	1985	TPA-treated ML-1 and ML-2 cells became firmly surface adhesive with a fibroblastoid morphology, while TPA-treated HL-60 cells adhered as rounded macrophages.	Tetradecanoylphorbol Acetate	0-3	interleukin 17F	Homo sapiens	12-16
3857122-7	1985	The acquisition of surface adhesiveness by TPA-treated ML-1 and ML-2 cells coincided with the appearance of membrane surface proteins of varying molecular weights, ranging between 90,000 and 155,000, which were not labeled in untreated ML-1 and ML-2 cells.	Tetradecanoylphorbol Acetate	43-46	interleukin 17F	Homo sapiens	55-59
3857122-7	1985	The acquisition of surface adhesiveness by TPA-treated ML-1 and ML-2 cells coincided with the appearance of membrane surface proteins of varying molecular weights, ranging between 90,000 and 155,000, which were not labeled in untreated ML-1 and ML-2 cells.	Tetradecanoylphorbol Acetate	43-46	interleukin 17F	Homo sapiens	236-240
3857122-8	1985	These findings and the results obtained by monoclonal antibody staining and FACS analysis indicate that treatment of the myeloid lines ML-1, ML-2, and HL-60 by TPA induced the expression of antigenic and membrane molecular features compatible with a monocytic-macrophage phenotype, while treatment by retinoic acid induced granulocytic differentiation.	Tetradecanoylphorbol Acetate	160-163	interleukin 17F	Homo sapiens	135-139
33019942-8	2021	It was observed that lapachol above 0.5 microM inhibited the activation of MMP-2 and MMP-9 stimulated by PMA.	Tetradecanoylphorbol Acetate	105-108	matrix metallopeptidase 2	Homo sapiens	75-80
33019942-9	2021	In particular, the protein and gene expression levels of MMP-2 stimulated by PMA were remarkably decreased in the presence of lapachol at 1 microM compared with PMA treatment group.	Tetradecanoylphorbol Acetate	77-80	matrix metallopeptidase 2	Homo sapiens	57-62
33019942-9	2021	In particular, the protein and gene expression levels of MMP-2 stimulated by PMA were remarkably decreased in the presence of lapachol at 1 microM compared with PMA treatment group.	Tetradecanoylphorbol Acetate	161-164	matrix metallopeptidase 2	Homo sapiens	57-62
33019942-12	2021	It was also found that the expression level of p65, a part of NF-kB, in nuclei was reduced in the presence of lapachol above 0.5 microM compared with PMA treatment group.	Tetradecanoylphorbol Acetate	150-153	RELA proto-oncogene, NF-kB subunit	Homo sapiens	47-50
3859584-2	1985	Using fasting human volunteers, we report that human epidermal and dermal ODC are consistently induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in a manner similar to that seen in mouse skin.	Tetradecanoylphorbol Acetate	125-161	ornithine decarboxylase 1	Homo sapiens	74-77
3859584-2	1985	Using fasting human volunteers, we report that human epidermal and dermal ODC are consistently induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in a manner similar to that seen in mouse skin.	Tetradecanoylphorbol Acetate	163-166	ornithine decarboxylase 1	Homo sapiens	74-77
3859584-3	1985	There is a marked intersubject variation in TPA-induced epidermal ODC activity levels.	Tetradecanoylphorbol Acetate	44-47	ornithine decarboxylase 1	Homo sapiens	66-69
32597024-8	2020	Relative to control subjects, in TTS patients, BNP suppression of both phorbol myristate acetate and N-formyl-methionyl-leucyl-phenylalanine-induced O2 - release was impaired acutely (P < 0.05 for both); this did not improve over the 3-month recovery period, despite treatment with conventional anti-failure medication in 85% of patients.	Tetradecanoylphorbol Acetate	71-96	natriuretic peptide B	Homo sapiens	47-50
3017734-8	1986	Thus, calcium channel blockade effectively dissociates the effects of tetradecanoylphorbol acetate (TPA) on TFR internalization and phosphorylation.	Tetradecanoylphorbol Acetate	100-103	transferrin receptor	Homo sapiens	108-111
2942536-1	1986	Thrombospondin (TSP) is a multifunctional platelet alpha-granule and extracellular matrix glycoprotein that binds specifically to plasminogen (Plg) via that protein"s lysine-binding site and modulates activation by tissue activator (TPA).	Tetradecanoylphorbol Acetate	233-236	plasminogen	Homo sapiens	143-146
33062701-10	2020	Meanwhile, ALN, PRP, or ALN combined with PRP reversed the inhibiting effect of phorbol myristate acetate (PMA, an NF-kappaB agonist) on cell proliferation and cartilage matrix metabolism.	Tetradecanoylphorbol Acetate	80-105	proline-rich protein 15	Rattus norvegicus	16-19
33062701-10	2020	Meanwhile, ALN, PRP, or ALN combined with PRP reversed the inhibiting effect of phorbol myristate acetate (PMA, an NF-kappaB agonist) on cell proliferation and cartilage matrix metabolism.	Tetradecanoylphorbol Acetate	80-105	proline-rich protein 15	Rattus norvegicus	42-45
3859584-4	1985	Orally administered compounds significantly inhibited TPA-caused human epidermal ODC induction.	Tetradecanoylphorbol Acetate	54-57	ornithine decarboxylase 1	Homo sapiens	81-84
2942536-2	1986	In this study we report that the plasminogen activators, TPA and urokinase, greatly influence the binding of Plg to TSP.	Tetradecanoylphorbol Acetate	57-60	plasminogen	Homo sapiens	109-112
2580209-4	1985	In agreement with a mutual influence between lysoPS and TPA, minimal TPA concentrations enhanced the calcium-dependent histamine release induced by lysoPS in the presence of nerve-growth factor.	Tetradecanoylphorbol Acetate	56-59	nerve growth factor	Rattus norvegicus	174-193
33062701-10	2020	Meanwhile, ALN, PRP, or ALN combined with PRP reversed the inhibiting effect of phorbol myristate acetate (PMA, an NF-kappaB agonist) on cell proliferation and cartilage matrix metabolism.	Tetradecanoylphorbol Acetate	107-110	proline-rich protein 15	Rattus norvegicus	42-45
2942536-8	1986	The increased amount of bound Plg was demonstrated to result in a similar increase in the amount of plasmin generated from the complexes by TPA.	Tetradecanoylphorbol Acetate	140-143	plasminogen	Homo sapiens	30-33
2580209-4	1985	In agreement with a mutual influence between lysoPS and TPA, minimal TPA concentrations enhanced the calcium-dependent histamine release induced by lysoPS in the presence of nerve-growth factor.	Tetradecanoylphorbol Acetate	69-72	nerve growth factor	Rattus norvegicus	174-193
2942536-8	1986	The increased amount of bound Plg was demonstrated to result in a similar increase in the amount of plasmin generated from the complexes by TPA.	Tetradecanoylphorbol Acetate	140-143	plasminogen	Homo sapiens	100-107
32983167-0	2020	In vivo Anti-inflammatory Activity of Lipidated Peptidomimetics Pam-(Lys-betaNspe)6-NH2 and Lau-(Lys-betaNspe)6-NH2 Against PMA-Induced Acute Inflammation.	Tetradecanoylphorbol Acetate	124-127	peptidylglycine alpha-amidating monooxygenase	Mus musculus	64-67
3013443-2	1986	It was found that human HGPRT+/HGPRT- SK-HEP-1 cells only, showed a metabolic cooperation capacity that was inhibited by tumour promoters 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital, and was not inhibited by the non-promoter 4-O-methyl TPA, provided suitable experimental conditions (short exposure times) were used.	Tetradecanoylphorbol Acetate	138-174	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	24-29
32048876-9	2020	These responses to PMA were attenuated by inhibition of mitoKATP or PICK1.	Tetradecanoylphorbol Acetate	19-22	protein interacting with PRKCA 1	Rattus norvegicus	68-73
3920341-10	1985	TPA induced a low level of IL-2 receptor expression in monocyte-depleted T cells, without inducing IL-2 secretion.	Tetradecanoylphorbol Acetate	0-3	interleukin 2 receptor subunit beta	Homo sapiens	27-40
3155775-1	1985	Phorbol myristate acetate (PMA) has been reported to confer on the C3b receptor (CR1) of neutrophils a capacity for phagocytosis of particles bearing C3b without the involvement of other membrane receptors.	Tetradecanoylphorbol Acetate	0-25	endogenous retrovirus group K member 3	Homo sapiens	150-153
3155775-1	1985	Phorbol myristate acetate (PMA) has been reported to confer on the C3b receptor (CR1) of neutrophils a capacity for phagocytosis of particles bearing C3b without the involvement of other membrane receptors.	Tetradecanoylphorbol Acetate	27-30	endogenous retrovirus group K member 3	Homo sapiens	67-70
3155775-1	1985	Phorbol myristate acetate (PMA) has been reported to confer on the C3b receptor (CR1) of neutrophils a capacity for phagocytosis of particles bearing C3b without the involvement of other membrane receptors.	Tetradecanoylphorbol Acetate	27-30	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	81-84
3155775-1	1985	Phorbol myristate acetate (PMA) has been reported to confer on the C3b receptor (CR1) of neutrophils a capacity for phagocytosis of particles bearing C3b without the involvement of other membrane receptors.	Tetradecanoylphorbol Acetate	27-30	endogenous retrovirus group K member 3	Homo sapiens	150-153
3013443-2	1986	It was found that human HGPRT+/HGPRT- SK-HEP-1 cells only, showed a metabolic cooperation capacity that was inhibited by tumour promoters 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital, and was not inhibited by the non-promoter 4-O-methyl TPA, provided suitable experimental conditions (short exposure times) were used.	Tetradecanoylphorbol Acetate	138-174	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	31-36
3970979-7	1985	In contrast, both the amino acids and their analogs increased the rates of proteolysis in isolated epidermal cells, an effect which correlated well with the abilities of these different compounds to inhibit TPA-induced ornithine decarboxylase activity.	Tetradecanoylphorbol Acetate	207-210	ornithine decarboxylase 1	Homo sapiens	219-242
3970979-8	1985	Moreover, both methionine and phenylalanine decreased the half-life and increased the rate of heat denaturation of the TPA-induced enzyme, a result identical to that obtained after treatment with the analogs ethionine and beta-2-thienyl-DL-alanine, respectively.	Tetradecanoylphorbol Acetate	119-122	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	222-228
3013443-2	1986	It was found that human HGPRT+/HGPRT- SK-HEP-1 cells only, showed a metabolic cooperation capacity that was inhibited by tumour promoters 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital, and was not inhibited by the non-promoter 4-O-methyl TPA, provided suitable experimental conditions (short exposure times) were used.	Tetradecanoylphorbol Acetate	176-179	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	24-29
2981678-0	1985	12-O-tetradecanoyl phorbol-13-acetate stimulates rat growth hormone (GH) release through different pathways from that of human pancreatic GH-releasing factor.	Tetradecanoylphorbol Acetate	0-37	gonadotropin releasing hormone receptor	Rattus norvegicus	53-67
2981678-0	1985	12-O-tetradecanoyl phorbol-13-acetate stimulates rat growth hormone (GH) release through different pathways from that of human pancreatic GH-releasing factor.	Tetradecanoylphorbol Acetate	0-37	gonadotropin releasing hormone receptor	Rattus norvegicus	69-71
32373641-8	2020	After 12 h, PMA-induced ROS production decreased, which was sustained until 48 h. The expressions of inflammation markers (IL1alpha, IL1beta, IL6, IL10, TNFalpha, STAT3, TLR4, MMP9, and HP) and eicosanoids (ALOX5, ALOX5AP, and PLA2G4A) were upregulated.	Tetradecanoylphorbol Acetate	12-15	interleukin 1 alpha	Bos taurus	123-131
32373641-8	2020	After 12 h, PMA-induced ROS production decreased, which was sustained until 48 h. The expressions of inflammation markers (IL1alpha, IL1beta, IL6, IL10, TNFalpha, STAT3, TLR4, MMP9, and HP) and eicosanoids (ALOX5, ALOX5AP, and PLA2G4A) were upregulated.	Tetradecanoylphorbol Acetate	12-15	interleukin 1 alpha	Bos taurus	133-140
32373641-8	2020	After 12 h, PMA-induced ROS production decreased, which was sustained until 48 h. The expressions of inflammation markers (IL1alpha, IL1beta, IL6, IL10, TNFalpha, STAT3, TLR4, MMP9, and HP) and eicosanoids (ALOX5, ALOX5AP, and PLA2G4A) were upregulated.	Tetradecanoylphorbol Acetate	12-15	interferon beta-2	Bos taurus	142-145
32373641-8	2020	After 12 h, PMA-induced ROS production decreased, which was sustained until 48 h. The expressions of inflammation markers (IL1alpha, IL1beta, IL6, IL10, TNFalpha, STAT3, TLR4, MMP9, and HP) and eicosanoids (ALOX5, ALOX5AP, and PLA2G4A) were upregulated.	Tetradecanoylphorbol Acetate	12-15	interleukin-10	Bos taurus	147-151
3013443-2	1986	It was found that human HGPRT+/HGPRT- SK-HEP-1 cells only, showed a metabolic cooperation capacity that was inhibited by tumour promoters 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital, and was not inhibited by the non-promoter 4-O-methyl TPA, provided suitable experimental conditions (short exposure times) were used.	Tetradecanoylphorbol Acetate	176-179	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	31-36
32373641-8	2020	After 12 h, PMA-induced ROS production decreased, which was sustained until 48 h. The expressions of inflammation markers (IL1alpha, IL1beta, IL6, IL10, TNFalpha, STAT3, TLR4, MMP9, and HP) and eicosanoids (ALOX5, ALOX5AP, and PLA2G4A) were upregulated.	Tetradecanoylphorbol Acetate	12-15	signal transducer and activator of transcription 3	Bos taurus	163-168
2424873-7	1986	Surface marker analysis revealed that the expression of CD2 to CD7 antigens (and also CD25) may be modified following incubation of the TLC with TPA or sodium butyrate but not with 5-azacytidine.	Tetradecanoylphorbol Acetate	145-148	interleukin 2 receptor subunit alpha	Homo sapiens	86-90
32373641-8	2020	After 12 h, PMA-induced ROS production decreased, which was sustained until 48 h. The expressions of inflammation markers (IL1alpha, IL1beta, IL6, IL10, TNFalpha, STAT3, TLR4, MMP9, and HP) and eicosanoids (ALOX5, ALOX5AP, and PLA2G4A) were upregulated.	Tetradecanoylphorbol Acetate	12-15	matrix metallopeptidase 9	Bos taurus	176-180
2981678-1	1985	The mechanism(s) of action of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on rat (r) GH release was studied in primary rat pituitary cell cultures.	Tetradecanoylphorbol Acetate	30-67	gonadotropin releasing hormone receptor	Rattus norvegicus	85-87
31939617-8	2020	Taken together, these results demonstrated that morin hydrate reduced the metastatic potential in TPA-treated MCF-7 human breast cancer cells via the inhibition of MMPs, uPA and uPAR, and the underlying Akt/GSK-3beta/c-Fos pathway.	Tetradecanoylphorbol Acetate	98-101	glycogen synthase kinase 3 alpha	Homo sapiens	207-216
3015642-0	1986	The protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), inhibits muscarinic (M1) receptor-mediated inositol phosphate release and cyclic GMP formation in murine neuroblastoma cells (clone N1E-115).	Tetradecanoylphorbol Acetate	32-68	5'-nucleotidase, cytosolic II	Mus musculus	157-160
31806018-9	2019	Contrariwise, frequencies of IL-13 mRNA-expressing cells were low even after PMA/ionomycin stimulation and mainly had a CD4-CD8beta- phenotype.	Tetradecanoylphorbol Acetate	77-80	interleukin 13	Gallus gallus	29-34
6083869-9	1984	Monocytic differentiation of the cell line HL60 by 12-O-tetradecanoylphorbol-13-acetate (TPA) and of cell line U 937 by dimethylsulfoxide and TPA was accompanied by a decrease in reactivity with these antibodies, which could be recovered by neuraminidase treatment.	Tetradecanoylphorbol Acetate	142-145	neuraminidase 1	Homo sapiens	241-254
6517531-1	1984	In preparation for experiments to determine the effects of various orally administered compounds on human skin ornithine decarboxylase (ODC) activity, it was observed that intradermal lidocaine hydrochloride inhibited 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced ODC.	Tetradecanoylphorbol Acetate	256-259	ornithine decarboxylase 1	Homo sapiens	136-139
31722779-0	2019	Transduced Tat-CIAPIN1 reduces the inflammatory response on LPS- and TPA-induced damages.	Tetradecanoylphorbol Acetate	69-72	tyrosine aminotransferase	Mus musculus	11-14
3015642-0	1986	The protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), inhibits muscarinic (M1) receptor-mediated inositol phosphate release and cyclic GMP formation in murine neuroblastoma cells (clone N1E-115).	Tetradecanoylphorbol Acetate	70-73	5'-nucleotidase, cytosolic II	Mus musculus	157-160
31722779-6	2019	In a TPA-induced animal model, transduced Tat-CIAPIN1 drastically decreased inflammation damage and inhibited COX-2, iNOS, IL-6, and TNF-alpha expression.	Tetradecanoylphorbol Acetate	5-8	tyrosine aminotransferase	Mus musculus	42-45
3011149-2	1986	Mo cells are a human T cell leukemia virus II-infected T cell line previously shown to secrete large quantities of MIF upon stimulation with phytohemagglutinin and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	164-189	macrophage migration inhibitory factor	Homo sapiens	115-118
31722779-6	2019	In a TPA-induced animal model, transduced Tat-CIAPIN1 drastically decreased inflammation damage and inhibited COX-2, iNOS, IL-6, and TNF-alpha expression.	Tetradecanoylphorbol Acetate	5-8	cytochrome c oxidase II, mitochondrial	Mus musculus	110-115
6149663-2	1984	12-O-tetradecanoyl phorbol-13-acetate (TPA), the most potent phorbol ester, stimulated GH accumulation in the cultured medium in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-37	gonadotropin releasing hormone receptor	Rattus norvegicus	87-89
6149663-2	1984	12-O-tetradecanoyl phorbol-13-acetate (TPA), the most potent phorbol ester, stimulated GH accumulation in the cultured medium in a dose-dependent manner.	Tetradecanoylphorbol Acetate	39-42	gonadotropin releasing hormone receptor	Rattus norvegicus	87-89
6149663-4	1984	A time course study indicated that TPA mainly stimulates release of GH.	Tetradecanoylphorbol Acetate	35-38	gonadotropin releasing hormone receptor	Rattus norvegicus	68-70
6149663-5	1984	The maximal stimulation of GH release by TPA (100 ng/ml) was 3-4-fold over control.	Tetradecanoylphorbol Acetate	41-44	gonadotropin releasing hormone receptor	Rattus norvegicus	27-29
6149663-7	1984	TPA-stimulated GH release was not affected by the presence of indomethacin, an inhibitor of prostaglandin (PG) synthesis, indicating that PG is not involved in the process of TPA-stimulated GH release.	Tetradecanoylphorbol Acetate	0-3	gonadotropin releasing hormone receptor	Rattus norvegicus	15-17
6149663-8	1984	Co++, a competitive antagonist of Ca++, at 2.0 mM completely suppressed the GH release induced by TPA, and this inhibition was partially reversed by the addition of 2.0 mM Ca++.	Tetradecanoylphorbol Acetate	98-101	gonadotropin releasing hormone receptor	Rattus norvegicus	76-78
31563324-4	2019	Both the expression of the differentiation marker CD14 and activation of the mTOR signaling pathway were induced by 1,25(OH)2D3 in phorbol 12-myristate 13-acetate (PMA)-differentiated U937 and THP-1 cells.	Tetradecanoylphorbol Acetate	131-162	CD14 molecule	Homo sapiens	50-54
3011152-5	1986	Induction of Tac antigen, a putative interleukin 2 (IL 2) receptor, was observed in two cases after cultivation with PMA or with a novel lymphokine, adult T cell leukemia-derived factor (ADF).	Tetradecanoylphorbol Acetate	117-120	interleukin 2 receptor subunit alpha	Homo sapiens	13-24
31563324-4	2019	Both the expression of the differentiation marker CD14 and activation of the mTOR signaling pathway were induced by 1,25(OH)2D3 in phorbol 12-myristate 13-acetate (PMA)-differentiated U937 and THP-1 cells.	Tetradecanoylphorbol Acetate	164-167	CD14 molecule	Homo sapiens	50-54
3084562-4	1986	Natural IFN-gamma in the TPA-Con A CM and rIFN-gamma (12.5-500 U/ml) induced major histocompatibility complex-class II antigens (HLA-DR, HLA-DP, and HLA-DQ) and significant lymphocyte adhesion to the EC, whereas rIFN-alpha did not.	Tetradecanoylphorbol Acetate	25-28	major histocompatibility complex, class II, DP beta 1	Homo sapiens	137-143
31361541-5	2019	Furthermore, IL-17A stimulation resulted in mRNA and protein expression of scavenger receptor (LOX-1) in phorbol 12-myristate 13-acetate (PMA)-activated U937 cells.	Tetradecanoylphorbol Acetate	105-136	oxidized low density lipoprotein receptor 1	Homo sapiens	95-100
31361541-5	2019	Furthermore, IL-17A stimulation resulted in mRNA and protein expression of scavenger receptor (LOX-1) in phorbol 12-myristate 13-acetate (PMA)-activated U937 cells.	Tetradecanoylphorbol Acetate	138-141	oxidized low density lipoprotein receptor 1	Homo sapiens	95-100
3008566-7	1986	Moreover, a direct stimulation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) (10(-8)-10(-6) M) also inhibited renin release and increased the calcium permeability of the cell membrane.	Tetradecanoylphorbol Acetate	41-77	renin	Rattus norvegicus	117-122
31636629-8	2019	Transfection with miR-124-5p mimics reduced the number of phagocytic cells as well as the phagocytic activity of phorbol-12-myristate-13-acetate (PMA)-activated THP-1 cells and ex vivo differentiated primary human macrophages.	Tetradecanoylphorbol Acetate	113-144	microRNA 1245a	Homo sapiens	18-28
31636629-8	2019	Transfection with miR-124-5p mimics reduced the number of phagocytic cells as well as the phagocytic activity of phorbol-12-myristate-13-acetate (PMA)-activated THP-1 cells and ex vivo differentiated primary human macrophages.	Tetradecanoylphorbol Acetate	146-149	microRNA 1245a	Homo sapiens	18-28
3008566-7	1986	Moreover, a direct stimulation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) (10(-8)-10(-6) M) also inhibited renin release and increased the calcium permeability of the cell membrane.	Tetradecanoylphorbol Acetate	79-82	renin	Rattus norvegicus	117-122
3005303-3	1986	Insulin receptor of tetradecanoyl-beta-phorbol acetate (TPA)-treated adipocytes was solubilized and partially purified, and its kinase activity was studied in vitro.	Tetradecanoylphorbol Acetate	20-54	insulin receptor	Rattus norvegicus	0-16
31448596-10	2019	Next, we set up a platform for real-time in vivo monitoring of the endogenously produced H2O2 in Caco-2 and MCF-7 cells through spermine-polyamine analogue and phorbol 12-myristate 13-acetate induction in SSAT/PAO gene and protein kinase C, respectively.	Tetradecanoylphorbol Acetate	160-191	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	205-209
31448596-10	2019	Next, we set up a platform for real-time in vivo monitoring of the endogenously produced H2O2 in Caco-2 and MCF-7 cells through spermine-polyamine analogue and phorbol 12-myristate 13-acetate induction in SSAT/PAO gene and protein kinase C, respectively.	Tetradecanoylphorbol Acetate	160-191	spermine oxidase	Homo sapiens	210-213
3005303-3	1986	Insulin receptor of tetradecanoyl-beta-phorbol acetate (TPA)-treated adipocytes was solubilized and partially purified, and its kinase activity was studied in vitro.	Tetradecanoylphorbol Acetate	56-59	insulin receptor	Rattus norvegicus	0-16
3005303-4	1986	We found that insulin (10(-7) M) increased the tyrosine autophosphorylation of the insulin receptor kinase from TPA-treated cells only 3-fold in contrast to a 12-fold stimulation in control cells.	Tetradecanoylphorbol Acetate	112-115	insulin receptor	Rattus norvegicus	83-99
3080229-7	1986	On treatment of quiescent BALB/3T3 cells with 100 ng of 12-O-tetradecanoylphorbol-13-acetate, p90 phosphorylation increased 2-fold in 1 min, reaching a peak in 15 min of 3.4-fold the initial value.	Tetradecanoylphorbol Acetate	56-92	transferrin receptor	Mus musculus	94-97
31053301-3	2019	TPA as an activator of the ERK pathway markedly induced ErbB4 phosphorylation at Thr-674, the conserved common feedback site in the intracellular JM domain, which resulted in the downregulation of tyrosine autophosphorylation.	Tetradecanoylphorbol Acetate	0-3	erb-b2 receptor tyrosine kinase 4	Homo sapiens	56-61
3080229-8	1986	The phosphorylation of p90 increased with increase in the concentrations of 12-O-tetradecanoylphorbol-13-acetate between 0.1 and 10 ng/ml and reached a plateau at 10 ng/ml.	Tetradecanoylphorbol Acetate	76-112	transferrin receptor	Mus musculus	23-26
3077972-11	1986	Ornithine decarboxylase, another enzyme that is rapidly induced by tumor promoters, is inhibited by both cycloheximide and actinomycin D in the presence of TPA (O"Brien, 1976).	Tetradecanoylphorbol Acetate	156-159	ornithine decarboxylase 1	Homo sapiens	0-23
31285782-9	2019	We found that PMA induced tyrosine phosphorylation of protein tyrosine kinases (PTKs), such as focal adhesion kinase (FAK), protein tyrosine kinase 2 (Pyk2), and Src, and increased actin stress fiber formation in a ROS-dependent manner.	Tetradecanoylphorbol Acetate	14-17	protein tyrosine kinase 2	Homo sapiens	95-116
31285782-9	2019	We found that PMA induced tyrosine phosphorylation of protein tyrosine kinases (PTKs), such as focal adhesion kinase (FAK), protein tyrosine kinase 2 (Pyk2), and Src, and increased actin stress fiber formation in a ROS-dependent manner.	Tetradecanoylphorbol Acetate	14-17	protein tyrosine kinase 2	Homo sapiens	118-121
31285782-9	2019	We found that PMA induced tyrosine phosphorylation of protein tyrosine kinases (PTKs), such as focal adhesion kinase (FAK), protein tyrosine kinase 2 (Pyk2), and Src, and increased actin stress fiber formation in a ROS-dependent manner.	Tetradecanoylphorbol Acetate	14-17	protein tyrosine kinase 2	Homo sapiens	124-149
31285782-9	2019	We found that PMA induced tyrosine phosphorylation of protein tyrosine kinases (PTKs), such as focal adhesion kinase (FAK), protein tyrosine kinase 2 (Pyk2), and Src, and increased actin stress fiber formation in a ROS-dependent manner.	Tetradecanoylphorbol Acetate	14-17	protein tyrosine kinase 2	Homo sapiens	151-155
3086629-4	1986	Phorbol 12-myristate 13-acetate (PMA) could induce Tac antigen in all cases.	Tetradecanoylphorbol Acetate	0-31	interleukin 2 receptor subunit alpha	Homo sapiens	51-62
3086629-4	1986	Phorbol 12-myristate 13-acetate (PMA) could induce Tac antigen in all cases.	Tetradecanoylphorbol Acetate	33-36	interleukin 2 receptor subunit alpha	Homo sapiens	51-62
3099098-7	1986	The changes in PK-C activity in TPA + RA-treated cells were accompanied by Ca2+/phospholipid(PL)-dependent phosphorylation in vitro of pp38 which is characteristic of treatment with RA alone, as well as the Ca2+/PL-independent phosphorylation in vitro of pp82 and pp130 (vinculin) which is prevalent in cells treated continuously with TPA alone and is absent in RA-treated cells.	Tetradecanoylphorbol Acetate	32-35	vinculin	Homo sapiens	271-279
30849519-4	2019	Here we show that protein kinase C agonist, phorbol esters (PMA), reduces TTF1 protein levels in time- and dose-dependent manners, without altering TTF1 mRNA levels.	Tetradecanoylphorbol Acetate	60-63	transcription termination factor 1	Homo sapiens	74-78
30849519-5	2019	TTF1 is ubiquitinated and degraded in the proteasome in response to PMA, suggesting that PMA induces TTF1 degradation in the ubiquitin-proteasome system.	Tetradecanoylphorbol Acetate	68-71	transcription termination factor 1	Homo sapiens	0-4
2978964-3	1986	Furthermore, when stimulated with PMA (phorbol-myristate-acetate), the C3b receptor-mediated phagocytosis in cord blood monocytes was enhanced to the same extent as in monocytes from adults.	Tetradecanoylphorbol Acetate	34-37	endogenous retrovirus group K member 3	Homo sapiens	71-74
30849519-5	2019	TTF1 is ubiquitinated and degraded in the proteasome in response to PMA, suggesting that PMA induces TTF1 degradation in the ubiquitin-proteasome system.	Tetradecanoylphorbol Acetate	68-71	transcription termination factor 1	Homo sapiens	101-105
30849519-6	2019	Furthermore, we demonstrate that an E3 ubiquitin ligase, named HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HECW1), targets TTF1 for its ubiquitination and degradation, while downregulation of HECW1 attenuates PMA-induced TTF1 ubiquitination and degradation.	Tetradecanoylphorbol Acetate	230-233	transcription termination factor 1	Homo sapiens	144-148
30849519-6	2019	Furthermore, we demonstrate that an E3 ubiquitin ligase, named HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HECW1), targets TTF1 for its ubiquitination and degradation, while downregulation of HECW1 attenuates PMA-induced TTF1 ubiquitination and degradation.	Tetradecanoylphorbol Acetate	230-233	transcription termination factor 1	Homo sapiens	242-246
30707387-3	2019	After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages.	Tetradecanoylphorbol Acetate	33-64	interleukin 37	Homo sapiens	228-242
30707387-3	2019	After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages.	Tetradecanoylphorbol Acetate	66-69	interleukin 37	Homo sapiens	228-242
2978964-3	1986	Furthermore, when stimulated with PMA (phorbol-myristate-acetate), the C3b receptor-mediated phagocytosis in cord blood monocytes was enhanced to the same extent as in monocytes from adults.	Tetradecanoylphorbol Acetate	39-64	endogenous retrovirus group K member 3	Homo sapiens	71-74
30707387-3	2019	After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages.	Tetradecanoylphorbol Acetate	66-69	interleukin 37	Homo sapiens	244-249
3159792-8	1985	Phorbol myristate acetate (0.1 ng/ml) increased CR1 230% and CR3 265%.	Tetradecanoylphorbol Acetate	0-25	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	48-51
31070650-6	2019	Furthermore, TPA obviously assuaged TNF-alpha-evoked up-regulation of IL-8 and IL-6 expression, down-regulation of occludin and ZO-3 expression, and markedly suppressed the activation and protein expression of NF-kappaB p65.	Tetradecanoylphorbol Acetate	13-16	RELA proto-oncogene, NF-kB subunit	Homo sapiens	220-223
31070650-7	2019	Our results indicated that TPA assuages the TNF-alpha-evoked dysfunction of the intestinal epithelial barrier by inhibiting the NF-kappaB p65-mediated inflammatory response.	Tetradecanoylphorbol Acetate	27-30	RELA proto-oncogene, NF-kB subunit	Homo sapiens	138-141
3159792-8	1985	Phorbol myristate acetate (0.1 ng/ml) increased CR1 230% and CR3 265%.	Tetradecanoylphorbol Acetate	0-25	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	61-64
3161505-3	1985	Simultaneous presence of A23187 and OAG or TPA resulted in a synergistic response that mimicked the full physiological response to gonadotropin releasing hormone (GnRH).	Tetradecanoylphorbol Acetate	43-46	gonadotropin releasing hormone 1	Homo sapiens	131-161
30936203-4	2019	Our results demonstrate that direct activation of PKC via the phorbol ester phorbol 12-myristate 13-acetate (PMA) mimics CXCL12-mediated desensitization, internalization, ubiquitination, and lysosomal trafficking of CXCR4.	Tetradecanoylphorbol Acetate	76-107	C-X-C motif chemokine ligand 12	Homo sapiens	121-127
30936203-4	2019	Our results demonstrate that direct activation of PKC via the phorbol ester phorbol 12-myristate 13-acetate (PMA) mimics CXCL12-mediated desensitization, internalization, ubiquitination, and lysosomal trafficking of CXCR4.	Tetradecanoylphorbol Acetate	109-112	C-X-C motif chemokine ligand 12	Homo sapiens	121-127
3161505-3	1985	Simultaneous presence of A23187 and OAG or TPA resulted in a synergistic response that mimicked the full physiological response to gonadotropin releasing hormone (GnRH).	Tetradecanoylphorbol Acetate	43-46	gonadotropin releasing hormone 1	Homo sapiens	163-167
3859699-0	1985	In vitro induction of human skin ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	79-115	ornithine decarboxylase 1	Homo sapiens	33-56
30668803-7	2019	Inhibition of GJIC by PAHs, similarly to a prototypic GJIC-inhibitor TPA, was mediated via the MAP kinase-Erk1/2 and PKC pathways.	Tetradecanoylphorbol Acetate	69-72	mitogen-activated protein kinase 3	Mus musculus	106-112
3859699-1	1985	A method was developed for the in vitro induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) of ornithine decarboxylase (ODC) activity in human skin punch biopsy samples.	Tetradecanoylphorbol Acetate	53-89	ornithine decarboxylase 1	Homo sapiens	99-122
31010051-3	2019	Upon stimulating IL-32theta-expressing and non-expressing cells with phorbol 12-myristate 13-acetate (PMA), the previous microarray analysis showed that IL-13Ralpha2 and IL-13 mRNA expression were significantly decreased by IL-32theta.	Tetradecanoylphorbol Acetate	69-100	interleukin 13 receptor subunit alpha 2	Homo sapiens	153-165
3859699-1	1985	A method was developed for the in vitro induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) of ornithine decarboxylase (ODC) activity in human skin punch biopsy samples.	Tetradecanoylphorbol Acetate	53-89	ornithine decarboxylase 1	Homo sapiens	124-127
31010051-3	2019	Upon stimulating IL-32theta-expressing and non-expressing cells with phorbol 12-myristate 13-acetate (PMA), the previous microarray analysis showed that IL-13Ralpha2 and IL-13 mRNA expression were significantly decreased by IL-32theta.	Tetradecanoylphorbol Acetate	102-105	interleukin 13 receptor subunit alpha 2	Homo sapiens	153-165
3859699-1	1985	A method was developed for the in vitro induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) of ornithine decarboxylase (ODC) activity in human skin punch biopsy samples.	Tetradecanoylphorbol Acetate	91-94	ornithine decarboxylase 1	Homo sapiens	99-122
3859699-1	1985	A method was developed for the in vitro induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) of ornithine decarboxylase (ODC) activity in human skin punch biopsy samples.	Tetradecanoylphorbol Acetate	91-94	ornithine decarboxylase 1	Homo sapiens	124-127
3859699-2	1985	Addition of TPA to 1 ml serum-free minimum essential medium containing a single 3-mm human skin punch biopsy sample obtained from a surgical specimen resulted in an induction of ODC activity with a peak activity at 5 hours after TPA addition.	Tetradecanoylphorbol Acetate	12-15	ornithine decarboxylase 1	Homo sapiens	178-181
3859699-2	1985	Addition of TPA to 1 ml serum-free minimum essential medium containing a single 3-mm human skin punch biopsy sample obtained from a surgical specimen resulted in an induction of ODC activity with a peak activity at 5 hours after TPA addition.	Tetradecanoylphorbol Acetate	229-232	ornithine decarboxylase 1	Homo sapiens	178-181
30544224-9	2019	In addition, PSEN1-P242LfsX11 mediates cytokine and chemokine expression and prolongs tumor necrosis factor alpha production on the inflammatory processes in THP-1 cells and phorbol-12-myristate-13-acetate-differentiated macrophages in response to lipopolysaccharide stimulation.	Tetradecanoylphorbol Acetate	174-205	presenilin 1	Homo sapiens	13-18
3859699-3	1985	In vitro induction of human epidermal ODC activity was dependent on the TPA concentration in the medium; about a twofold increase in ODC activity was observed 6 hours after the addition of 0.1 microM TPA, and about a fivefold increase in ODC activity was observed with 1 microM TPA.	Tetradecanoylphorbol Acetate	72-75	ornithine decarboxylase 1	Homo sapiens	38-41
3859699-3	1985	In vitro induction of human epidermal ODC activity was dependent on the TPA concentration in the medium; about a twofold increase in ODC activity was observed 6 hours after the addition of 0.1 microM TPA, and about a fivefold increase in ODC activity was observed with 1 microM TPA.	Tetradecanoylphorbol Acetate	72-75	ornithine decarboxylase 1	Homo sapiens	133-136
3859699-3	1985	In vitro induction of human epidermal ODC activity was dependent on the TPA concentration in the medium; about a twofold increase in ODC activity was observed 6 hours after the addition of 0.1 microM TPA, and about a fivefold increase in ODC activity was observed with 1 microM TPA.	Tetradecanoylphorbol Acetate	72-75	ornithine decarboxylase 1	Homo sapiens	133-136
30513386-8	2019	More importantly, in vitro stimulation of lymphocytes agonist PMA augmented phosphorylation level of On-c-Raf in leukocytes detected by western-blot and immunofluorescent.	Tetradecanoylphorbol Acetate	62-65	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	104-109
3859699-3	1985	In vitro induction of human epidermal ODC activity was dependent on the TPA concentration in the medium; about a twofold increase in ODC activity was observed 6 hours after the addition of 0.1 microM TPA, and about a fivefold increase in ODC activity was observed with 1 microM TPA.	Tetradecanoylphorbol Acetate	200-203	ornithine decarboxylase 1	Homo sapiens	38-41
3859699-3	1985	In vitro induction of human epidermal ODC activity was dependent on the TPA concentration in the medium; about a twofold increase in ODC activity was observed 6 hours after the addition of 0.1 microM TPA, and about a fivefold increase in ODC activity was observed with 1 microM TPA.	Tetradecanoylphorbol Acetate	200-203	ornithine decarboxylase 1	Homo sapiens	133-136
30664308-8	2019	Moreover, TPA, an agonist of protein kinase C, induced phosphorylation of fascin and dissociation from actin filaments in lamellipodia.	Tetradecanoylphorbol Acetate	10-13	fascin actin-bundling protein 1	Homo sapiens	74-80
30664308-9	2019	Time series images showed that dissociation of fascin from the actin meshwork was induced by TPA.	Tetradecanoylphorbol Acetate	93-96	fascin actin-bundling protein 1	Homo sapiens	47-53
3859699-3	1985	In vitro induction of human epidermal ODC activity was dependent on the TPA concentration in the medium; about a twofold increase in ODC activity was observed 6 hours after the addition of 0.1 microM TPA, and about a fivefold increase in ODC activity was observed with 1 microM TPA.	Tetradecanoylphorbol Acetate	200-203	ornithine decarboxylase 1	Homo sapiens	133-136
3859699-3	1985	In vitro induction of human epidermal ODC activity was dependent on the TPA concentration in the medium; about a twofold increase in ODC activity was observed 6 hours after the addition of 0.1 microM TPA, and about a fivefold increase in ODC activity was observed with 1 microM TPA.	Tetradecanoylphorbol Acetate	200-203	ornithine decarboxylase 1	Homo sapiens	38-41
3859699-3	1985	In vitro induction of human epidermal ODC activity was dependent on the TPA concentration in the medium; about a twofold increase in ODC activity was observed 6 hours after the addition of 0.1 microM TPA, and about a fivefold increase in ODC activity was observed with 1 microM TPA.	Tetradecanoylphorbol Acetate	200-203	ornithine decarboxylase 1	Homo sapiens	133-136
3859699-3	1985	In vitro induction of human epidermal ODC activity was dependent on the TPA concentration in the medium; about a twofold increase in ODC activity was observed 6 hours after the addition of 0.1 microM TPA, and about a fivefold increase in ODC activity was observed with 1 microM TPA.	Tetradecanoylphorbol Acetate	200-203	ornithine decarboxylase 1	Homo sapiens	133-136
30566262-8	2019	Up-regulation of cytokines (TSLP, IL-4, IL-5, IL-13, RANTES) in human mast cells treated with phorbol 12-myristate 13-acetate and calcium ionophore was also suppressed by boehmite.	Tetradecanoylphorbol Acetate	94-125	interleukin 5	Homo sapiens	40-44
3859699-4	1985	TPA also caused about a fivefold to sixfold increase in ODC activity in 3-mm skin punch biopsy samples from healthy volunteers.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase 1	Homo sapiens	56-59
3859699-5	1985	Human skin punch biopsy samples remained responsive to TPA induction of ODC activity even when stored in serum-free medium at 4 degrees C for 24 hours.	Tetradecanoylphorbol Acetate	55-58	ornithine decarboxylase 1	Homo sapiens	72-75
3859699-6	1985	A similar degree of induction of ODC activity by TPA was observed whether whole unfractionated human epidermis or a soluble epidermal extract was used for ODC assays.	Tetradecanoylphorbol Acetate	49-52	ornithine decarboxylase 1	Homo sapiens	33-36
3859699-6	1985	A similar degree of induction of ODC activity by TPA was observed whether whole unfractionated human epidermis or a soluble epidermal extract was used for ODC assays.	Tetradecanoylphorbol Acetate	49-52	ornithine decarboxylase 1	Homo sapiens	155-158
2986949-3	1985	It is observed that a tumor promoter, phorbol myristate acetate (PMA), binds specifically to the cells (Ka = 5 X 10(8) M-1; 3.9 X 10(11) receptors/mg), reduces (33%) the affinity but not the number of EGF receptors, and stimulates hCG to the same extent as does EGF.	Tetradecanoylphorbol Acetate	38-63	hypertrichosis 2 (generalised, congenital)	Homo sapiens	231-234
30654737-8	2019	The prime plasminogen activators (tissue- and urokinase-type plasminogen activator, tPA and uPA) first occur in cartilaginous fish and phylogenetic analyses confirm that all orthologues identified compose monophyletic groups to their mammalian counterparts.	Tetradecanoylphorbol Acetate	84-87	plasminogen	Homo sapiens	10-21
2986949-3	1985	It is observed that a tumor promoter, phorbol myristate acetate (PMA), binds specifically to the cells (Ka = 5 X 10(8) M-1; 3.9 X 10(11) receptors/mg), reduces (33%) the affinity but not the number of EGF receptors, and stimulates hCG to the same extent as does EGF.	Tetradecanoylphorbol Acetate	65-68	hypertrichosis 2 (generalised, congenital)	Homo sapiens	231-234
2986949-4	1985	The relative potencies of PMA (100%), phorbol dibutyrate (25%), and nonesterified phorbol (no effect) to stimulate hCG parallel their known tumor-promoting activities.	Tetradecanoylphorbol Acetate	26-29	hypertrichosis 2 (generalised, congenital)	Homo sapiens	115-118
30665329-7	2019	PMA dose-dependently upregulated ppNOC mRNA but downregulated NOP mRNA in human peripheral blood leukocytes.	Tetradecanoylphorbol Acetate	0-3	opioid related nociceptin receptor 1	Homo sapiens	62-65
6586291-0	1984	Glycosaminoglycan synthesis during differentiation of HL60/HGPRT-leukemia cells induced by dimethyl sulfoxide and 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	114-150	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	59-64
2986949-8	1985	Nordihydroguairetic acid (a cyclooxygenase and lipoxygenase inhibitor) reduced by 90% basal and EGF- or PMA-stimulated hCG secretion.	Tetradecanoylphorbol Acetate	104-107	hypertrichosis 2 (generalised, congenital)	Homo sapiens	119-122
6586291-5	1984	Treatment of HL60/HGPRT- cultures with dimethyl sulfoxide, which initiates myeloid maturation, or 12-O-tetradecanoylphorbol-13- acetate, which induces the formation of macrophage-like cells, resulted in a 43 and 34% reduction, respectively, of the incorporation of [35S]sulfate into total GAGs at a time when greater than 80% of the cells were morphologically immature and were unable to reduce nitroblue tetrazolium dye.	Tetradecanoylphorbol Acetate	98-135	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	18-23
3918848-3	1985	TRH, K+, VIP, and TPA all caused secretion within 1 min in the perifusion system but the peak response to TRH and depolarization occurred earlier than the peak responses to TPA and VIP.	Tetradecanoylphorbol Acetate	18-21	thyrotropin releasing hormone	Rattus norvegicus	106-109
6328483-3	1984	The intracellular levels of this RNA product were increased 2.5- to 5-fold by exposure of the cells to epidermal growth factor (EGF) and 2- to 3-fold by exposure of the cells to a potent phorbol ester, phorbol 12-myristate 13-acetate, apparently due to regulation at the level of gene transcription.	Tetradecanoylphorbol Acetate	202-233	epidermal growth factor like 1	Rattus norvegicus	103-138
30242126-7	2018	In contrast, elevated basal expression of membrane-bound CD14 in phorbol 12-myristate 13-acetate (PMA)-THP-1 cells, primary monocytes, and primary macrophages may promote CD14-mediated endocytosis and be responsible for the preservation of an endotoxin-tolerized state in the presence of IL-27.	Tetradecanoylphorbol Acetate	65-96	CD14 molecule	Homo sapiens	57-61
30242126-7	2018	In contrast, elevated basal expression of membrane-bound CD14 in phorbol 12-myristate 13-acetate (PMA)-THP-1 cells, primary monocytes, and primary macrophages may promote CD14-mediated endocytosis and be responsible for the preservation of an endotoxin-tolerized state in the presence of IL-27.	Tetradecanoylphorbol Acetate	65-96	CD14 molecule	Homo sapiens	171-175
30242126-7	2018	In contrast, elevated basal expression of membrane-bound CD14 in phorbol 12-myristate 13-acetate (PMA)-THP-1 cells, primary monocytes, and primary macrophages may promote CD14-mediated endocytosis and be responsible for the preservation of an endotoxin-tolerized state in the presence of IL-27.	Tetradecanoylphorbol Acetate	65-96	interleukin 27	Homo sapiens	288-293
30384862-6	2018	Previously, protein kinase C activator phorbol 12-myristate 13-acetate (PMA)-induced increase of mesenchymal stem cell adhesion via activation of focal adhesion kinase (FAK) has been reported.	Tetradecanoylphorbol Acetate	39-70	protein tyrosine kinase 2	Homo sapiens	146-167
3881194-1	1985	The human promyelocytic leukemia line HL-60 when treated with a phorbol diester (TPA) differentiates into cells (HL60-TPA) that respond to human migration inhibitory factor (MIF).	Tetradecanoylphorbol Acetate	81-84	macrophage migration inhibitory factor	Homo sapiens	145-172
30384862-6	2018	Previously, protein kinase C activator phorbol 12-myristate 13-acetate (PMA)-induced increase of mesenchymal stem cell adhesion via activation of focal adhesion kinase (FAK) has been reported.	Tetradecanoylphorbol Acetate	39-70	protein tyrosine kinase 2	Homo sapiens	169-172
30384862-6	2018	Previously, protein kinase C activator phorbol 12-myristate 13-acetate (PMA)-induced increase of mesenchymal stem cell adhesion via activation of focal adhesion kinase (FAK) has been reported.	Tetradecanoylphorbol Acetate	72-75	protein tyrosine kinase 2	Homo sapiens	146-167
30384862-6	2018	Previously, protein kinase C activator phorbol 12-myristate 13-acetate (PMA)-induced increase of mesenchymal stem cell adhesion via activation of focal adhesion kinase (FAK) has been reported.	Tetradecanoylphorbol Acetate	72-75	protein tyrosine kinase 2	Homo sapiens	169-172
3881194-1	1985	The human promyelocytic leukemia line HL-60 when treated with a phorbol diester (TPA) differentiates into cells (HL60-TPA) that respond to human migration inhibitory factor (MIF).	Tetradecanoylphorbol Acetate	81-84	macrophage migration inhibitory factor	Homo sapiens	174-177
6323046-5	1984	The present studies suggest that the C-3, C-20 and C-30 hydroxyl groups of the aplysiatoxins are involved in binding to the specific receptor of TPA.	Tetradecanoylphorbol Acetate	145-148	complement component 3	Mus musculus	37-40
3881194-1	1985	The human promyelocytic leukemia line HL-60 when treated with a phorbol diester (TPA) differentiates into cells (HL60-TPA) that respond to human migration inhibitory factor (MIF).	Tetradecanoylphorbol Acetate	118-121	macrophage migration inhibitory factor	Homo sapiens	145-172
30353147-4	2018	Using our TPA model, we have demonstrated that spontaneous diastolic depolarization observed in atrial myocytes with TBX5-deletion can be explained by altered intracellular calcium handling and suppression of inward-rectifier potassium current (IK1).	Tetradecanoylphorbol Acetate	10-13	IKAROS family zinc finger 1	Homo sapiens	245-248
3881194-1	1985	The human promyelocytic leukemia line HL-60 when treated with a phorbol diester (TPA) differentiates into cells (HL60-TPA) that respond to human migration inhibitory factor (MIF).	Tetradecanoylphorbol Acetate	118-121	macrophage migration inhibitory factor	Homo sapiens	174-177
3881194-2	1985	Unresponsive HL-60 cells became responsive to MIF when preincubated with a glycolipid-enriched preparation extracted from HL60-TPA cells, human monocytes, human macrophage-like (U937) cell line, or with the purified glycolipid receptor for MIF from guinea pig peritoneal macrophages.	Tetradecanoylphorbol Acetate	127-130	macrophage migration inhibitory factor	Homo sapiens	46-49
6421503-5	1984	TPA and teleocidin B also increased ODC activity in LHC-0 medium (a maintenance medium without epidermal growth factor) but caused a decrease of ODC activity in LHC-4 (a growth medium containing epidermal growth factor).	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase 1	Homo sapiens	36-39
3881194-3	1985	Human blood monocytes exhibited an increased response to MIF when preincubated with glycolipids from HL60-TPA and U937 cells but not from HL-60 cells.	Tetradecanoylphorbol Acetate	106-109	macrophage migration inhibitory factor	Homo sapiens	57-60
6421503-5	1984	TPA and teleocidin B also increased ODC activity in LHC-0 medium (a maintenance medium without epidermal growth factor) but caused a decrease of ODC activity in LHC-4 (a growth medium containing epidermal growth factor).	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase 1	Homo sapiens	145-148
30308980-8	2018	This formulation effectively ameliorated TPA-induced hyperplasia, by reducing skin edema, epidermal thickness, MPO activity and COX-2 expression.	Tetradecanoylphorbol Acetate	41-44	cytochrome c oxidase II, mitochondrial	Mus musculus	128-133
3881194-4	1985	Finally, glycolipids from HL60-TPA cells but not from HL-60 cells were able to reversibly bind MIF when covalently coupled to agarose.	Tetradecanoylphorbol Acetate	31-34	macrophage migration inhibitory factor	Homo sapiens	95-98
6421503-6	1984	Finally, TPA and teleocidin B each caused an increase of PA and a decrease of AHH activities in both media.	Tetradecanoylphorbol Acetate	9-12	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	78-81
3881194-5	1985	These studies suggest that TPA induces the differentiation of HL-60 cells into MIF-responsive cells through the expression of a glycolipid receptor for MIF.	Tetradecanoylphorbol Acetate	27-30	macrophage migration inhibitory factor	Homo sapiens	79-82
3881194-5	1985	These studies suggest that TPA induces the differentiation of HL-60 cells into MIF-responsive cells through the expression of a glycolipid receptor for MIF.	Tetradecanoylphorbol Acetate	27-30	macrophage migration inhibitory factor	Homo sapiens	152-155
2986660-4	1985	The tumor-promoting agent 12-O-tetradecanoyl-phorbol-13-acetate (TPA), however, induced in both systems ODC activity, without an effect on the cAMP concentration.	Tetradecanoylphorbol Acetate	26-63	ornithine decarboxylase 1	Homo sapiens	104-107
6717062-7	1984	In all cell lines, exposure to TPA resulted in an approximately two-fold increase in acid phosphatase and beta-glucuronidase activity.	Tetradecanoylphorbol Acetate	31-34	glucuronidase beta	Homo sapiens	106-124
29886054-2	2018	In vitro treatment with IL-18 or ionomycin/PMA successfully stimulated and activated the cells via a significant increase in the expression of CD69, B-Lec, CHIR-AB1 and NK-lysin.	Tetradecanoylphorbol Acetate	43-46	CD69 molecule	Homo sapiens	143-147
2986660-4	1985	The tumor-promoting agent 12-O-tetradecanoyl-phorbol-13-acetate (TPA), however, induced in both systems ODC activity, without an effect on the cAMP concentration.	Tetradecanoylphorbol Acetate	65-68	ornithine decarboxylase 1	Homo sapiens	104-107
29883943-6	2018	To confirm the positive effects on inflammation, TPA (12-O-tetradecanoylphorbol-13-acetate) induced inflammation measured by mouse ear thickness and biopsy punch weight and TPA-induced iNOS, COX-2 mRNA and protein expression were remarkably suppressed by 50 and 100 mg/kg ZPE-LR oral-administration.	Tetradecanoylphorbol Acetate	49-52	cytochrome c oxidase II, mitochondrial	Mus musculus	191-196
6225775-4	1983	Both calcium and phosphatidylserine were required for vinculin phosphorylation by protein kinase C. In addition, both phorbol 12,13-dibutyrate (10 nM) and phorbol 12-myristate 13-acetate (10 nM) stimulated vinculin phosphorylation by protein kinase C at a limiting calcium concentration (10(-6) M).	Tetradecanoylphorbol Acetate	155-186	vinculin	Homo sapiens	54-62
6517947-0	1984	Oxidised glutathione reductase activity in mouse epidermis: TPA induced change and its modulation by vitamin A.	Tetradecanoylphorbol Acetate	60-63	glutathione reductase	Mus musculus	9-30
6225775-4	1983	Both calcium and phosphatidylserine were required for vinculin phosphorylation by protein kinase C. In addition, both phorbol 12,13-dibutyrate (10 nM) and phorbol 12-myristate 13-acetate (10 nM) stimulated vinculin phosphorylation by protein kinase C at a limiting calcium concentration (10(-6) M).	Tetradecanoylphorbol Acetate	155-186	vinculin	Homo sapiens	206-214
29883943-6	2018	To confirm the positive effects on inflammation, TPA (12-O-tetradecanoylphorbol-13-acetate) induced inflammation measured by mouse ear thickness and biopsy punch weight and TPA-induced iNOS, COX-2 mRNA and protein expression were remarkably suppressed by 50 and 100 mg/kg ZPE-LR oral-administration.	Tetradecanoylphorbol Acetate	173-176	cytochrome c oxidase II, mitochondrial	Mus musculus	191-196
29883943-7	2018	In addition, TPA-induced iNOS, COX-2 mRNA level and protein expression were reduced.	Tetradecanoylphorbol Acetate	13-16	cytochrome c oxidase II, mitochondrial	Mus musculus	31-36
30015874-0	2018	P2X7 receptor regulates EMMPRIN and MMP-9 expression through AMPK/MAPK signaling in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	84-87	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	61-65
30015874-7	2018	The present study also demonstrated that 5"-AMP-activated protein kinase (AMPK) was activated by PMA exposure during differentiation from monocytes to macrophages.	Tetradecanoylphorbol Acetate	97-100	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	74-78
6311062-3	1983	A similar loss of binding to and inactivation of human neutrophil elastase was observed on exposure of alpha 1-protease inhibitor to human neutrophils in the presence of a halide and the neutrophil-activating agent, phorbol myristate acetate.	Tetradecanoylphorbol Acetate	216-241	elastase, neutrophil expressed	Homo sapiens	55-74
6517947-1	1984	Single cutaneous application of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) increased epidermal oxidised glutathione reductase activity in adult mouse by almost 100%.	Tetradecanoylphorbol Acetate	32-69	glutathione reductase	Mus musculus	105-126
6517947-1	1984	Single cutaneous application of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) increased epidermal oxidised glutathione reductase activity in adult mouse by almost 100%.	Tetradecanoylphorbol Acetate	71-74	glutathione reductase	Mus musculus	105-126
6334715-8	1984	CSA also blocked lymphokine release from a phorbol myristate acetate-stimulated thymoma cell line, EL-4.	Tetradecanoylphorbol Acetate	43-68	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	0-3
30122755-3	2018	Flow cytometry was used to detect the purity and expansion folds of gammadeltaT cells, and the expression of CD107a on gammadeltaT cells after PMA/ionomycin stimulated.	Tetradecanoylphorbol Acetate	143-146	lysosomal associated membrane protein 1	Homo sapiens	109-115
30122755-8	2018	After being stimulated by PMA/ionomycin, the proportion of CD107a+ gammadeltaT cells increased significantly, reaching 40%-82%.	Tetradecanoylphorbol Acetate	26-29	lysosomal associated membrane protein 1	Homo sapiens	59-65
6407752-2	1983	The relevance of these TPA-induced changes to the mechanism of tumor promotion was investigated using alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ODC.	Tetradecanoylphorbol Acetate	23-26	ornithine decarboxylase 1	Homo sapiens	169-172
6489452-4	1984	), while a change to fresh medium stimulated the ODC to maximum activity after 4-6 h. The activity was not altered by the presence of RA in the fresh medium, but TPA partially inhibited the medium-stimulated ODC activity.	Tetradecanoylphorbol Acetate	162-165	ornithine decarboxylase 1	Homo sapiens	208-211
6298128-5	1983	Prolonged treatment of L12 cells with TPA, a tumor cell promoter, gave rise to L12T cells that synthesize the p53 protein and exhibit a lethal tumor phenotype.	Tetradecanoylphorbol Acetate	38-41	skull development traits QTL 1	Mus musculus	23-26
30058806-6	2018	The expression levels of p-ERK1/2 and p-p38 mitogen-activated protein kinase (MAPK) in the TPA group were 5.3, 4.8, and 5.7 but downregulated to 2.7, 2.9, and 2.3 in the Nob group and 2.4, 2.7, and 1.2 in the 5-HPMF group, respectively ( p &lt;= 0.05).	Tetradecanoylphorbol Acetate	91-94	mitogen-activated protein kinase 3	Mus musculus	27-33
30288224-4	2018	It was indicated that GA, applied topically onto mouse ears, effectively inhibited the TPA-mediated expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner, respectively.	Tetradecanoylphorbol Acetate	87-90	prostaglandin-endoperoxide synthase 2	Mus musculus	158-174
6489452-5	1984	Cells treated for 4 or 8 days with TPA or a combination of TPA and RA had a low ODC activity which could not be induced by fresh medium.	Tetradecanoylphorbol Acetate	35-38	ornithine decarboxylase 1	Homo sapiens	80-83
30288224-4	2018	It was indicated that GA, applied topically onto mouse ears, effectively inhibited the TPA-mediated expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner, respectively.	Tetradecanoylphorbol Acetate	87-90	prostaglandin-endoperoxide synthase 2	Mus musculus	176-181
6489452-5	1984	Cells treated for 4 or 8 days with TPA or a combination of TPA and RA had a low ODC activity which could not be induced by fresh medium.	Tetradecanoylphorbol Acetate	59-62	ornithine decarboxylase 1	Homo sapiens	80-83
6149663-9	1984	Verapamil, a Ca++ channel blocker, reduced TPA-stimulated GH release, and trifluoperazine, an inhibitor of Ca-calmodulin formation, had a similar effect.	Tetradecanoylphorbol Acetate	43-46	gonadotropin releasing hormone receptor	Rattus norvegicus	58-60
6872136-6	1983	The possibility was tested that the increased amount of the protein may have represented increased ornithine decarboxylase activity in response to TPA treatment.	Tetradecanoylphorbol Acetate	147-150	ornithine decarboxylase 1	Homo sapiens	99-122
6149663-10	1984	Somatostatin (SRIF) also inhibited the GH release by TPA.	Tetradecanoylphorbol Acetate	53-56	gonadotropin releasing hormone receptor	Rattus norvegicus	39-41
6149663-11	1984	These observations are compatible with the idea that Ca++ may be involved in the process of TPA-stimulated GH release.	Tetradecanoylphorbol Acetate	92-95	gonadotropin releasing hormone receptor	Rattus norvegicus	107-109
6423277-8	1984	TPA treatment of two cultured villous adenomas, one with infiltrating carcinoma and one with focus of moderately dysplastic cells, in the presence of low serum to decrease the plasmin concentration, demonstrated that only a subpopulation of cells secreted PA. Local areas of the monolayer were morphologically altered by the protease, forming clusters of cells loosely attached to the dish.	Tetradecanoylphorbol Acetate	0-3	plasminogen	Homo sapiens	176-183
6151562-1	1983	The activity of histidine decarboxylase (HDC) increased by a factor of 10 after a single application of 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	104-140	histidine decarboxylase	Mus musculus	16-39
6151562-1	1983	The activity of histidine decarboxylase (HDC) increased by a factor of 10 after a single application of 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	104-140	histidine decarboxylase	Mus musculus	41-44
6151562-1	1983	The activity of histidine decarboxylase (HDC) increased by a factor of 10 after a single application of 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	142-145	histidine decarboxylase	Mus musculus	16-39
6151562-1	1983	The activity of histidine decarboxylase (HDC) increased by a factor of 10 after a single application of 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	142-145	histidine decarboxylase	Mus musculus	41-44
6325215-0	1984	12-O-tetradecanoyl-phorbol-13-acetate-induced ACTH secretion in pituitary tumor cells.	Tetradecanoylphorbol Acetate	0-37	pro-opiomelanocortin-alpha	Mus musculus	46-50
6243065-8	1983	Inspection of Dreiding models showed that the oxygens on C-27, C-3, and C-30 of aplysiatoxin are aligned with the oxygens on C-3, C-4, and C-20 of TPA, respectively.	Tetradecanoylphorbol Acetate	147-150	complement component 3	Mus musculus	63-66
6243065-8	1983	Inspection of Dreiding models showed that the oxygens on C-27, C-3, and C-30 of aplysiatoxin are aligned with the oxygens on C-3, C-4, and C-20 of TPA, respectively.	Tetradecanoylphorbol Acetate	147-150	complement component 3	Mus musculus	72-75
6325215-1	1984	The ability of the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) to stimulate secretion of immunoreactive ACTH from a clonal strain of mouse pituitary tumor cells (AtT-20/D16-16), was investigated.	Tetradecanoylphorbol Acetate	33-70	pro-opiomelanocortin-alpha	Mus musculus	118-122
6325215-1	1984	The ability of the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) to stimulate secretion of immunoreactive ACTH from a clonal strain of mouse pituitary tumor cells (AtT-20/D16-16), was investigated.	Tetradecanoylphorbol Acetate	72-75	pro-opiomelanocortin-alpha	Mus musculus	118-122
6956579-7	1982	In contrast, C3b-opsonized yeast and phorbol 12-myristate 13-acetate (PMA) did not enhance the CL response conspicuosly until days 3-4.	Tetradecanoylphorbol Acetate	70-73	endogenous retrovirus group K member 3	Homo sapiens	13-16
6325215-4	1984	TPA, even at maximally effective concentrations, had an additive effect on ACTH secretion when co-applied with other agonists such as corticotropin releasing factor, vasoactive intestinal peptide, or (1)-isoproterenol.	Tetradecanoylphorbol Acetate	0-3	pro-opiomelanocortin-alpha	Mus musculus	75-79
6325215-5	1984	Secretion of ACTH in response to TPA was reduced by lowering extracellular calcium concentration or in the presence of the calcium channel blocker, nifedipine.	Tetradecanoylphorbol Acetate	33-36	pro-opiomelanocortin-alpha	Mus musculus	13-17
6606672-6	1984	The most consistent change induced by TPA was the appearance of BB-1, a marker of activated B lymphocytes, which was rarely expressed on fresh leukemic cells.	Tetradecanoylphorbol Acetate	38-41	CD80 molecule	Homo sapiens	64-68
6325020-6	1983	Addition of parathyroid hormone (PTH) or dibutyryl cyclic AMP simultaneously with TPA overcame the inhibition caused by TPA.	Tetradecanoylphorbol Acetate	120-123	parathyroid hormone	Oryctolagus cuniculus	12-31
6279298-1	1982	A series of homologous spin-labeled fatty acid analogs of the type 12-O-FASL (n,m)-phorbol-13-acetate [(n,m)PA] of 12-O-tetradecanoylphorbol-13-acetate (TPA) with variable chain length N of the fatty acid moiety and various positions of the nitroxide group were synthesized.	Tetradecanoylphorbol Acetate	115-151	Fas ligand (TNF superfamily, member 6)	Mus musculus	72-76
6190556-2	1983	Synthesis of myosin heavy chain is remarkably inhibited after exposure to 1.6 X 10(-7) M TPA for periods of 9 hr or longer.	Tetradecanoylphorbol Acetate	89-92	myosin, heavy chain 15	Gallus gallus	13-31
6100978-2	1983	TPA, like ACTH, caused an increase in steroid production and a decrease in growth in Y1 cells.	Tetradecanoylphorbol Acetate	0-3	pro-opiomelanocortin-alpha	Mus musculus	10-14
7172413-1	1982	Isolated epidermal cells were incubated with a variety of compounds known to interfere with or alter the ultrastructure of cell surface receptors, and the ability of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) to bind to these cells and induce epidermal ornithine decarboxylase (ODC) activity was investigated.	Tetradecanoylphorbol Acetate	166-203	ornithine decarboxylase 1	Homo sapiens	254-277
6170583-7	1981	IFN produced after stimulation with TPA or mezerein, singly or in combination with phytohemagglutinin, had several properties characteristic of IFN-gamma, e.g., it was largely inactivated by dialysis at pH 2, or after exposure to sodium dodecyl sulfate, whereas it was not neutralized by antibody to IFN-alpha and IFN-beta.	Tetradecanoylphorbol Acetate	36-39	interferon beta 1	Homo sapiens	314-322
6958361-0	1982	Kinetics of appearance of differentiation-associated characteristics in ML-1, a line of human myeloblastic leukemia cells, after treatment with 12-O-tetradecanoylphorbol-13-acetate, dimethyl sulfoxide or 1-beta-D-arabinofuranosylcytosine.	Tetradecanoylphorbol Acetate	144-180	interleukin 17F	Homo sapiens	72-76
7259759-0	1981	Increase in histidine decarboxylase activity in mouse skin after application of the tumor promoter tetradecanoylphorbol acetate.	Tetradecanoylphorbol Acetate	99-127	histidine decarboxylase	Mus musculus	12-35
6960352-0	1982	Increase in histidine decarboxylase activity in skin of genetically mast-cell-deficient W/Wv mice after application of phorbol 12-myristate 13-acetate: evidence for the presence of histamine-producing cells without basophilic granules.	Tetradecanoylphorbol Acetate	119-150	histidine decarboxylase	Mus musculus	12-35
6260353-3	1981	The present study confirms those observations and further documents the induction, by 16 nM phorbol myristate acetate, of 5"-nucleotidase activity, another human macrophage marker enzyme.	Tetradecanoylphorbol Acetate	92-117	5'-nucleotidase ecto	Homo sapiens	122-137
6960352-1	1982	Histidine decarboxylase (HisDCase, EC 4.1.1.22) activity in mouse skin increased by a factor of more than 10 after a single application of phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	139-170	histidine decarboxylase	Mus musculus	0-23
6960352-1	1982	Histidine decarboxylase (HisDCase, EC 4.1.1.22) activity in mouse skin increased by a factor of more than 10 after a single application of phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	139-170	histidine decarboxylase	Mus musculus	25-33
6965103-3	1981	The appearance of an Ad5-specific cytopathic effect (CPE) was also accelerated in infected cultures exposed to TPA, whereas phorbol, 4 alpha-phorbol-12,13-didecanoate and 4-OmeTPA, which are inactive as tumor promoters, were ineffective in inducing this morphological change.	Tetradecanoylphorbol Acetate	111-114	Alzheimer disease, familial, type 5	Homo sapiens	21-24
6965103-4	1981	The acceleration of the CPE seen in TPA-treated Ad5-infected cells was not caused by TPA induction of the protease plasminogen activator, since the protease inhibitors leupeptin and antipain do not inhibit the earlier onset of this CPE and, in contrast, epidermal growth factor, which induces plasminogen activator in HeLa cells, does not induce an earlier CPE.	Tetradecanoylphorbol Acetate	36-39	Alzheimer disease, familial, type 5	Homo sapiens	48-51
7126637-11	1982	Secretion of beta-glucuronidase in response to N-formylmethionylleucylphenylalanine was also diminished by increasing the time of exposure to the initial stimulus of phorbol myristate acetate.	Tetradecanoylphorbol Acetate	166-191	glucuronidase beta	Homo sapiens	13-31
6965103-6	1981	TPA accelerated the appearance of mRNA from all major early regions of Ad5, transiently stimulated the accumulation of region III mRNA, and accelerated the appearance of late Ad5 mRNA.	Tetradecanoylphorbol Acetate	0-3	Alzheimer disease, familial, type 5	Homo sapiens	71-74
6965103-6	1981	TPA accelerated the appearance of mRNA from all major early regions of Ad5, transiently stimulated the accumulation of region III mRNA, and accelerated the appearance of late Ad5 mRNA.	Tetradecanoylphorbol Acetate	0-3	Alzheimer disease, familial, type 5	Homo sapiens	175-178
6965103-7	1981	Thus, TPA altered the temporal program of Ad5 mRNA production and accelerated the appearance of at least some Ad5-specific polypeptides during lytic infection of human cells.	Tetradecanoylphorbol Acetate	6-9	Alzheimer disease, familial, type 5	Homo sapiens	42-45
6965103-7	1981	Thus, TPA altered the temporal program of Ad5 mRNA production and accelerated the appearance of at least some Ad5-specific polypeptides during lytic infection of human cells.	Tetradecanoylphorbol Acetate	6-9	Alzheimer disease, familial, type 5	Homo sapiens	110-113
6965103-8	1981	These effects presumably explain the earlier onset of the Ad5-specific CPE in TPA-treated cells and may have relevance to the effects of TPA on viral gene expression in nonpermissive cells carrying integrated viral deoxyribonucleic acid sequences.	Tetradecanoylphorbol Acetate	78-81	Alzheimer disease, familial, type 5	Homo sapiens	58-61
6965103-8	1981	These effects presumably explain the earlier onset of the Ad5-specific CPE in TPA-treated cells and may have relevance to the effects of TPA on viral gene expression in nonpermissive cells carrying integrated viral deoxyribonucleic acid sequences.	Tetradecanoylphorbol Acetate	137-140	Alzheimer disease, familial, type 5	Homo sapiens	58-61
6283481-6	1982	Addition of crude extracts of cells grown in presence of TPA to the purified DNA polymerase alpha did not inhibit its activity indicating that the observed loss was not due to any specific inhibitor present in TPA treated cells.	Tetradecanoylphorbol Acetate	57-60	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	77-97
6970201-10	1980	TPA blocks the decrease in the number of short microvilli in EGF-treated cells, but not in NGF-treated cells.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor like 1	Rattus norvegicus	61-64
7172413-3	1982	Neuraminidase treatments caused a time- and dose-related release of sialic acid from the cells and enhanced the stimulatory effect of cholera toxin on basal and TPA-induced ODC activities as much as the monosialoganglioside GM1.	Tetradecanoylphorbol Acetate	161-164	neuraminidase 1	Homo sapiens	0-13
7172413-3	1982	Neuraminidase treatments caused a time- and dose-related release of sialic acid from the cells and enhanced the stimulatory effect of cholera toxin on basal and TPA-induced ODC activities as much as the monosialoganglioside GM1.	Tetradecanoylphorbol Acetate	161-164	ornithine decarboxylase 1	Homo sapiens	173-176
6246173-4	1980	The tumor promoter phorbol myristate acetate had no effect on the variation in either cyclic AMP or cyclic GMP, but did appear to reduce the extent of diurnal variation in cyclic GMP/cyclic AMP ratios.	Tetradecanoylphorbol Acetate	19-44	5'-nucleotidase, cytosolic II	Mus musculus	179-182
7172413-8	1982	In addition, the inhibitory effect of retinoic acid on TPA-induced ODC activity remained unaffected by some of the above treatments, suggesting that retinoic acid is unlikely to interfere with TPA interactions at the plasma membrane level.	Tetradecanoylphorbol Acetate	55-58	ornithine decarboxylase 1	Homo sapiens	67-70
6796074-0	1981	Intracellular calcium and skin tumor promotion: calcium regulation of the induction of epidermal ornithine decarboxylase activity by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	152-188	ornithine decarboxylase 1	Homo sapiens	97-120
6169058-2	1980	In a short term cell incubation, TPA and EGF caused an approximately 2-fold increase in the production of alpha-fetoprotein (AFP) and other acid-precipitable materials, while the same concentration of insulin brought a 3-fold increase.	Tetradecanoylphorbol Acetate	33-36	alpha-fetoprotein	Rattus norvegicus	106-123
6169058-2	1980	In a short term cell incubation, TPA and EGF caused an approximately 2-fold increase in the production of alpha-fetoprotein (AFP) and other acid-precipitable materials, while the same concentration of insulin brought a 3-fold increase.	Tetradecanoylphorbol Acetate	33-36	alpha-fetoprotein	Rattus norvegicus	125-128
6272736-10	1981	General activating and cytotoxic effects of TPA were monitored by determining release of lysozyme, beta-glucuronidase and lactate dehydrogenase.	Tetradecanoylphorbol Acetate	44-47	glucuronidase beta	Homo sapiens	99-117
6169058-4	1980	These biological effects of TPA, insulin and EGF appeared to resemble each other, and subsequent hormone binding studies showed that TPA inhibited 125I-EGF binding to its membrane receptors without affecting 125I-insulin binding.	Tetradecanoylphorbol Acetate	133-136	epidermal growth factor like 1	Rattus norvegicus	152-155
6169058-5	1980	Scatchard analysis of TPA effect on EGF binding indicated that TPA altered the affinity of the membrane receptors for EGF without changing the total number of available receptors per cell.	Tetradecanoylphorbol Acetate	22-25	epidermal growth factor like 1	Rattus norvegicus	36-39
6169058-5	1980	Scatchard analysis of TPA effect on EGF binding indicated that TPA altered the affinity of the membrane receptors for EGF without changing the total number of available receptors per cell.	Tetradecanoylphorbol Acetate	22-25	epidermal growth factor like 1	Rattus norvegicus	118-121
6169058-5	1980	Scatchard analysis of TPA effect on EGF binding indicated that TPA altered the affinity of the membrane receptors for EGF without changing the total number of available receptors per cell.	Tetradecanoylphorbol Acetate	63-66	epidermal growth factor like 1	Rattus norvegicus	36-39
6169058-5	1980	Scatchard analysis of TPA effect on EGF binding indicated that TPA altered the affinity of the membrane receptors for EGF without changing the total number of available receptors per cell.	Tetradecanoylphorbol Acetate	63-66	epidermal growth factor like 1	Rattus norvegicus	118-121
6970201-5	1980	Tetradecanoyl-phorbol-acetate (TPA), a potent tumor promoter, blocks the EGF-induced increase in adhesion rate of PC-12 cells, but does not alter the NGF-induced increase in adhesion rate.	Tetradecanoylphorbol Acetate	0-29	epidermal growth factor like 1	Rattus norvegicus	73-76
6970201-5	1980	Tetradecanoyl-phorbol-acetate (TPA), a potent tumor promoter, blocks the EGF-induced increase in adhesion rate of PC-12 cells, but does not alter the NGF-induced increase in adhesion rate.	Tetradecanoylphorbol Acetate	31-34	epidermal growth factor like 1	Rattus norvegicus	73-76
498078-2	1979	The effects of this agent on each cell type were different: (a) in hamster embryo cells, TPA induced ODC but had no effect on DNA synthesis; (b) TPA induced ODC and stimulated DNA synthesis in BALB/c 3T3 mouse cells; (c) it did not induce ODC in human fibroblasts but did stimulate DNA synthesis; and (d) it induced neither ODC nor DNA synthesis in rat embryo fibroblasts.	Tetradecanoylphorbol Acetate	145-148	ornithine decarboxylase 1	Homo sapiens	157-160
6970201-6	1980	TPA shifts the EGF bindings curve to the right for PC-12 cells, but does not alter maximal EGF binding at saturating concentrations of EGF.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor like 1	Rattus norvegicus	15-18
6154532-3	1980	Inducers of the first class, among which were dimethyl sulfoxide and hexamethylene bisacetamide, stimulated ODC activity and were inhibited by dexamethasone and the phorbol diester, 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	182-218	ornithine decarboxylase 1	Homo sapiens	108-111
322507-2	1977	Phorbol myristate acetate (PMA, 2 to 100 ng/ml) and ionophore A23187 (10(-7) to 10(-6) M) cause human neutrophils to release up to 50% of the granule-associated enzyme lysozyme extracellularly without release of beta-glucuronidase or the cytoplasmic enzyme LDH.	Tetradecanoylphorbol Acetate	0-25	glucuronidase beta	Homo sapiens	212-230
649665-1	1978	The potent tumor promoter tetradecanoyl phorbol acetate (TPA) induces early changes in ion movements analogous to those induced by prostaglandins E1 and F 2alpha.	Tetradecanoylphorbol Acetate	26-55	skull morphology 2	Mus musculus	146-161
29632235-5	2018	Chromatin immunoprecipitation studies and electrophoretic mobility shift assay using phorbol 12-myristate 13-acetate (PMA)-treated human erythroleukemia cells revealed RUNX1 binding to RAB1B promoter region RUNX1 consensus sites, and their mutation reduced the promoter activity.	Tetradecanoylphorbol Acetate	85-116	RAB1B, member RAS oncogene family	Homo sapiens	185-190
29632235-5	2018	Chromatin immunoprecipitation studies and electrophoretic mobility shift assay using phorbol 12-myristate 13-acetate (PMA)-treated human erythroleukemia cells revealed RUNX1 binding to RAB1B promoter region RUNX1 consensus sites, and their mutation reduced the promoter activity.	Tetradecanoylphorbol Acetate	118-121	RAB1B, member RAS oncogene family	Homo sapiens	185-190
322507-2	1977	Phorbol myristate acetate (PMA, 2 to 100 ng/ml) and ionophore A23187 (10(-7) to 10(-6) M) cause human neutrophils to release up to 50% of the granule-associated enzyme lysozyme extracellularly without release of beta-glucuronidase or the cytoplasmic enzyme LDH.	Tetradecanoylphorbol Acetate	27-30	glucuronidase beta	Homo sapiens	212-230
34043350-5	2021	Under anaerobic conditions, the direct reduction of these radicals by GSH also occurs with rate constants (kGSH) from 1.8 x 10-4 M-1 s-1 for TPA to 1.0 x 10-2 M-1 s-1 for TGA.	Tetradecanoylphorbol Acetate	141-144	T-box transcription factor 1	Homo sapiens	171-174
33760219-8	2021	BTK inhibitors [ibrutinib (10 microM), CNX-774 (10 microM)] significantly attenuated TPA-induced cell invasion and migration in MCF-7 cells and inhibited the activation of the phospholipase Cgamma2/PKCbeta signaling pathways.	Tetradecanoylphorbol Acetate	85-88	phospholipase C gamma 2	Homo sapiens	176-197
34043988-3	2021	In this study, we evaluated the effect of topically applied Baricitinib, JAK1/2 inhibitor on chronic 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced psoriasis model in mice.	Tetradecanoylphorbol Acetate	101-137	Janus kinase 1	Mus musculus	73-79
29458014-4	2018	Subsequently l-theanine ameliorated TPA-induced erythema, vascular permeability increase, epidermal and dermal hyperplasia, neutrophil infiltration and activation via downregulating the expression of PECAM-1 (a platelet endothelial adhesion molecule-1) in blood vessels and the production of pro-inflammatory cytokines IL-1beta, TNF-alpha, and mediator cyclooxygenase-2 (COX-2), which is mainly expressed in neutrophils.	Tetradecanoylphorbol Acetate	36-39	prostaglandin-endoperoxide synthase 2	Mus musculus	371-376
29462589-5	2018	Lithol Rubine B (LR-B, Pigment Red 57) and its calcium salt (LR-BCA), commonly used cosmetic colorants, potentiated phorbol-12-myristate-13-acetate-induced TSLP production in keratinocytes.	Tetradecanoylphorbol Acetate	116-147	thymic stromal lymphopoietin	Mus musculus	156-160
29535732-7	2018	More importantly, MEK1/2 inhibitors significantly increased the TLR9-mediated IFN-I production blocked in both GEN2.2 cells and primary pDCs upon stimulation of BCR-like or phorbol 12-myristate 13-acetate-induced protein kinase C (PKC) signaling.	Tetradecanoylphorbol Acetate	173-204	toll like receptor 9	Homo sapiens	64-68
33760219-0	2021	Bruton"s agammaglobulinemia tyrosine kinase (Btk) regulates TPA-induced breast cancer cell invasion via PLCgamma2/PKCbeta/NF-kappaB/AP-1-dependent matrix metalloproteinase-9 activation.	Tetradecanoylphorbol Acetate	60-63	phospholipase C gamma 2	Homo sapiens	104-113
33865856-4	2021	We report here that monomeric wild type (WT) mouse SK1 (GFP-mSK1) translocates to the PM of MCF-7L cells stimulated with carbachol or phorbol myristate acetate (PMA), whereas the dimer translocates to the PM in response to sphingosine 1-phosphate (S1P); thus, the equilibrium between monomer and dimer is sensitive to cellular stimulus.	Tetradecanoylphorbol Acetate	134-159	sphingosine kinase 1	Mus musculus	51-54
33865856-4	2021	We report here that monomeric wild type (WT) mouse SK1 (GFP-mSK1) translocates to the PM of MCF-7L cells stimulated with carbachol or phorbol myristate acetate (PMA), whereas the dimer translocates to the PM in response to sphingosine 1-phosphate (S1P); thus, the equilibrium between monomer and dimer is sensitive to cellular stimulus.	Tetradecanoylphorbol Acetate	161-164	sphingosine kinase 1	Mus musculus	51-54
33075145-8	2021	RESULTS: THP-1 monocytes pretreated with PMA (100ng/mL) for 48 h followed by culturing in PMA free media for another 48 h yielded cells with morphological characteristics similar to macrophages with a high percentage of adherence capability and CD-14 expression.	Tetradecanoylphorbol Acetate	41-44	CD14 molecule	Homo sapiens	245-250
33923123-0	2021	Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-Associated NOD2 Mutations.	Tetradecanoylphorbol Acetate	71-96	nucleotide binding oligomerization domain containing 2	Homo sapiens	129-133
33923123-0	2021	Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-Associated NOD2 Mutations.	Tetradecanoylphorbol Acetate	71-96	nucleotide binding oligomerization domain containing 2	Homo sapiens	154-158
33923123-6	2021	RESULTS: Although the production of proinflammatory cytokines was not altered without stimulation, mutant NOD2-expressing THP-1 cells attached persistently to the culture plate after stimulation with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	200-225	nucleotide binding oligomerization domain containing 2	Homo sapiens	106-110
33528492-4	2021	Importantly, we corroborated the pivotal role of C7ORF41 during keratinocyte differentiation by C7ORF41 knockdown or overexpression in TPA-induced Hacat keratinocytes.	Tetradecanoylphorbol Acetate	135-138	maturin, neural progenitor differentiation regulator homolog	Homo sapiens	49-56
33528492-6	2021	Furthermore, we also demonstrated that inhibiting the PKCalpha/ERK signaling pathway reversed the reduction of C7ORF41 in TPA-induced keratinocytes, indicating that C7ORF41 expression could be regulated by upstream PKCalpha/ERK signaling pathway during keratinocyte differentiation.	Tetradecanoylphorbol Acetate	122-125	maturin, neural progenitor differentiation regulator homolog	Homo sapiens	111-118
33528492-6	2021	Furthermore, we also demonstrated that inhibiting the PKCalpha/ERK signaling pathway reversed the reduction of C7ORF41 in TPA-induced keratinocytes, indicating that C7ORF41 expression could be regulated by upstream PKCalpha/ERK signaling pathway during keratinocyte differentiation.	Tetradecanoylphorbol Acetate	122-125	maturin, neural progenitor differentiation regulator homolog	Homo sapiens	165-172
33581408-14	2021	Meanwhile, EP also abolished MAPK ERK1/2 and p38 activation during PMA-induced NET formation.	Tetradecanoylphorbol Acetate	67-70	mitogen-activated protein kinase 3	Mus musculus	34-40
33717069-7	2021	Overexpression of LOC645166 in Jurkat cells down-regulated the IL-23p19 expression and suppressed the JAK2/STAT3 signaling in response to stimulation by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	153-184	Janus kinase 2	Homo sapiens	102-106
33581408-14	2021	Meanwhile, EP also abolished MAPK ERK1/2 and p38 activation during PMA-induced NET formation.	Tetradecanoylphorbol Acetate	67-70	mitogen-activated protein kinase 14	Mus musculus	45-48
33514282-4	2021	Exposure of phorbol-12-myristate-13-acetate (PMA)-differentiated THP1 macrophages to the secretome of CSF conditioned ADSCs downregulated both pro-inflammatory (COX-2, TNFalpha) and anti-inflammatory (SOCS3, IL1RA, TGFbeta) genes in these cells.	Tetradecanoylphorbol Acetate	12-43	suppressor of cytokine signaling 3	Homo sapiens	201-206
33514282-4	2021	Exposure of phorbol-12-myristate-13-acetate (PMA)-differentiated THP1 macrophages to the secretome of CSF conditioned ADSCs downregulated both pro-inflammatory (COX-2, TNFalpha) and anti-inflammatory (SOCS3, IL1RA, TGFbeta) genes in these cells.	Tetradecanoylphorbol Acetate	12-43	transforming growth factor alpha	Homo sapiens	215-222
33514282-4	2021	Exposure of phorbol-12-myristate-13-acetate (PMA)-differentiated THP1 macrophages to the secretome of CSF conditioned ADSCs downregulated both pro-inflammatory (COX-2, TNFalpha) and anti-inflammatory (SOCS3, IL1RA, TGFbeta) genes in these cells.	Tetradecanoylphorbol Acetate	45-48	suppressor of cytokine signaling 3	Homo sapiens	201-206
33514282-4	2021	Exposure of phorbol-12-myristate-13-acetate (PMA)-differentiated THP1 macrophages to the secretome of CSF conditioned ADSCs downregulated both pro-inflammatory (COX-2, TNFalpha) and anti-inflammatory (SOCS3, IL1RA, TGFbeta) genes in these cells.	Tetradecanoylphorbol Acetate	45-48	transforming growth factor alpha	Homo sapiens	215-222
33567927-9	2021	Regression formulas revealed that Delta10  in distal lordosis resulted in Delta10  in TPA, associated with Delta100 mm in SVA or Delta3  in PT; Delta10  in proximal lordosis yielded Delta5  in TPA associated with Delta50 mm in SVA; and finally Delta10  in thoraco-lumbar junction yielded Delta2.5  in TPA associated with Delta25 mm in SVA and no impact on PT correction.	Tetradecanoylphorbol Acetate	86-89	delta like canonical Notch ligand 3	Homo sapiens	129-135
33578967-11	2021	The diterpenoid-induced inhibition of AQP1-4 expression was blocked by phorbol-12-myristate-13-acetate (PMA; agonist of PKC).	Tetradecanoylphorbol Acetate	71-102	aquaporin 1	Mus musculus	38-44
33357882-1	2021	A novel core-shell starch-based nanoparticles (CSS NPs) with a "hard" starch core and a "soft" poly (methyl acrylate) (PMA) shell was prepared and incorporated into a PPC/PLA blend.	Tetradecanoylphorbol Acetate	119-122	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	47-50
33578967-11	2021	The diterpenoid-induced inhibition of AQP1-4 expression was blocked by phorbol-12-myristate-13-acetate (PMA; agonist of PKC).	Tetradecanoylphorbol Acetate	104-107	aquaporin 1	Mus musculus	38-44
33310310-5	2021	RESULTS: The results provide evidence that topical treatment with HPSB significantly inhibits TPA-induced epidermal hyperplasia and leukocyte infiltration through the down-regulation of cyclooxygenase-2 (COX-2), matrix metalloprotein-9 (MMP-9), and ornithine decarboxylase (ODC) protein expression in mouse skin.	Tetradecanoylphorbol Acetate	94-97	prostaglandin-endoperoxide synthase 2	Mus musculus	186-202
33557943-6	2021	By using this antibody as a tool, we showed that protein kinase C (PKC)-mediated Dab2-pSer24 was a conservative signaling event when human platelets were activated by the platelet agonists such as thrombin, collagen, ADP, 12-O-tetradecanoylphorbol-13-acetate, and the thromboxane A2 activator U46619.	Tetradecanoylphorbol Acetate	222-258	DAB adaptor protein 2	Homo sapiens	81-85
33310310-5	2021	RESULTS: The results provide evidence that topical treatment with HPSB significantly inhibits TPA-induced epidermal hyperplasia and leukocyte infiltration through the down-regulation of cyclooxygenase-2 (COX-2), matrix metalloprotein-9 (MMP-9), and ornithine decarboxylase (ODC) protein expression in mouse skin.	Tetradecanoylphorbol Acetate	94-97	prostaglandin-endoperoxide synthase 2	Mus musculus	204-209
33310310-5	2021	RESULTS: The results provide evidence that topical treatment with HPSB significantly inhibits TPA-induced epidermal hyperplasia and leukocyte infiltration through the down-regulation of cyclooxygenase-2 (COX-2), matrix metalloprotein-9 (MMP-9), and ornithine decarboxylase (ODC) protein expression in mouse skin.	Tetradecanoylphorbol Acetate	94-97	matrix metallopeptidase 9	Mus musculus	212-235
33310310-5	2021	RESULTS: The results provide evidence that topical treatment with HPSB significantly inhibits TPA-induced epidermal hyperplasia and leukocyte infiltration through the down-regulation of cyclooxygenase-2 (COX-2), matrix metalloprotein-9 (MMP-9), and ornithine decarboxylase (ODC) protein expression in mouse skin.	Tetradecanoylphorbol Acetate	94-97	matrix metallopeptidase 9	Mus musculus	237-242
33074126-5	2021	An intermitted removal of PMA treatment reduced the mRNA levels of STC1 and TNFalpha but had no noticeable effects on the anti-inflammatory markers.	Tetradecanoylphorbol Acetate	26-29	stanniocalcin 1	Homo sapiens	67-71
33239616-8	2020	Consistently, we find that the CCL3-CCR5 axis suppresses PMA-induced enhancement of MMP-9 expression in macrophages.	Tetradecanoylphorbol Acetate	57-60	matrix metallopeptidase 9	Mus musculus	84-89
33144667-4	2020	Tetracycline-inducible BACH2 expression resulted in suppression of phorbol 12-myristate 13-acetate (PMA)/ionomycin-driven activation of a luciferase reporter containing BACH2/AP-1 target sequences from the mouse Ifng + 18k enhancer.	Tetradecanoylphorbol Acetate	67-98	BTB and CNC homology, basic leucine zipper transcription factor 2	Mus musculus	23-28
33027554-6	2020	Electron exchange between two TPA-TCBD entities in 3 seem to prolong lifetime of the CS state.	Tetradecanoylphorbol Acetate	30-33	citrate synthase	Homo sapiens	85-87
32971088-7	2020	An in vivo study showed that phloretin, applied topically to the dorsal skin of mice, suppressed the 12-O-tetradecanoylphorbol 13-acetate-induced expression of COX-2, a critical molecular target of many chemopreventive, as well as anti-inflammatory agents.	Tetradecanoylphorbol Acetate	101-137	cytochrome c oxidase II, mitochondrial	Mus musculus	160-165
33144667-4	2020	Tetracycline-inducible BACH2 expression resulted in suppression of phorbol 12-myristate 13-acetate (PMA)/ionomycin-driven activation of a luciferase reporter containing BACH2/AP-1 target sequences from the mouse Ifng + 18k enhancer.	Tetradecanoylphorbol Acetate	67-98	BTB and CNC homology, basic leucine zipper transcription factor 2	Mus musculus	169-174
33144667-4	2020	Tetracycline-inducible BACH2 expression resulted in suppression of phorbol 12-myristate 13-acetate (PMA)/ionomycin-driven activation of a luciferase reporter containing BACH2/AP-1 target sequences from the mouse Ifng + 18k enhancer.	Tetradecanoylphorbol Acetate	67-98	jun proto-oncogene	Mus musculus	175-179
32986985-0	2020	Effect of docosahexaenoic acid, phorbol myristate acetate, and insulin on the interaction of the FFA4 (short isoform) receptor with Rab proteins.	Tetradecanoylphorbol Acetate	32-57	RAB11A, member RAS oncogene family	Homo sapiens	132-135
33144667-4	2020	Tetracycline-inducible BACH2 expression resulted in suppression of phorbol 12-myristate 13-acetate (PMA)/ionomycin-driven activation of a luciferase reporter containing BACH2/AP-1 target sequences from the mouse Ifng + 18k enhancer.	Tetradecanoylphorbol Acetate	100-103	BTB and CNC homology, basic leucine zipper transcription factor 2	Mus musculus	23-28
32986985-5	2020	Phorbol myristate acetate, triggered a rapid association with early endosomes (Rab5), slow recycling to the plasma membrane (Rab11), and some receptor degradation (Rab7).	Tetradecanoylphorbol Acetate	0-25	RAB11A, member RAS oncogene family	Homo sapiens	125-130
33144667-4	2020	Tetracycline-inducible BACH2 expression resulted in suppression of phorbol 12-myristate 13-acetate (PMA)/ionomycin-driven activation of a luciferase reporter containing BACH2/AP-1 target sequences from the mouse Ifng + 18k enhancer.	Tetradecanoylphorbol Acetate	100-103	BTB and CNC homology, basic leucine zipper transcription factor 2	Mus musculus	169-174
32986985-5	2020	Phorbol myristate acetate, triggered a rapid association with early endosomes (Rab5), slow recycling to the plasma membrane (Rab11), and some receptor degradation (Rab7).	Tetradecanoylphorbol Acetate	0-25	RAB7B, member RAS oncogene family	Homo sapiens	164-168
33144667-4	2020	Tetracycline-inducible BACH2 expression resulted in suppression of phorbol 12-myristate 13-acetate (PMA)/ionomycin-driven activation of a luciferase reporter containing BACH2/AP-1 target sequences from the mouse Ifng + 18k enhancer.	Tetradecanoylphorbol Acetate	100-103	jun proto-oncogene	Mus musculus	175-179
32468667-4	2020	In particular, the peak TPA cross section of TAT-ZnP (436 GM) is significantly larger than that of the ZnP reference (59 GM).	Tetradecanoylphorbol Acetate	24-27	tyrosine aminotransferase	Homo sapiens	45-48
33178224-13	2020	These MoDC can be matured with PMA and ionomycin as noted by increased CD86 and CD40 expression, increased cytokine secretion (IL-1alpha, IL-10, MIP-1alpha, and IL-17A), a metabolic switch to aerobic glycolysis, and induction of T cell activation and proliferation following maturation.	Tetradecanoylphorbol Acetate	31-34	CD86 molecule	Bos taurus	71-75
32468667-5	2020	The delta TPA values of TAT-(ZnP) 2 and TAT-(ZnP) 3 further increase to 1031 and up to 1496 GM respectively, indicating the effect of incorporated ZnP units on the TPA properties.	Tetradecanoylphorbol Acetate	10-13	tyrosine aminotransferase	Homo sapiens	24-27
32468667-5	2020	The delta TPA values of TAT-(ZnP) 2 and TAT-(ZnP) 3 further increase to 1031 and up to 1496 GM respectively, indicating the effect of incorporated ZnP units on the TPA properties.	Tetradecanoylphorbol Acetate	10-13	tyrosine aminotransferase	Homo sapiens	40-43
32750368-6	2020	Phorbol myristate acetate increased alpha1A-adrenoceptor interaction with Rab5 and Rab9 but did not modify it with Rab7.	Tetradecanoylphorbol Acetate	0-25	adrenoceptor alpha 1A	Homo sapiens	36-56
32818536-9	2020	Phorbol 12-myristate 13-acetate (a PKC activator) administration significantly attenuated enhanced immobility and decreased social interaction time in stressed mice and increased the serotonin turnover.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, beta	Mus musculus	35-38
33154638-10	2020	The AgNPs-CIT were found to be non-toxic to MCF-7 cell-lines and inhibited PMA-induced activation of the NF-kappaBp65, and also the mRNA/protein expression of TNFalpha.	Tetradecanoylphorbol Acetate	75-78	RELA proto-oncogene, NF-kB subunit	Homo sapiens	105-117
32638255-6	2020	To determine the mechanism involved in increasing in the NF-kappaB activity of stimulated THP-1 cells, we examined the effects of PMA and ATRA on the expression of TLR9 (a receptor of ODN2006) in THP-1 cells.	Tetradecanoylphorbol Acetate	130-133	toll like receptor 9	Homo sapiens	164-168
32867392-1	2020	This study tested the hypothesis that MMP-9-/-tPA-/- double knock out (i.e., MTDKO) plays a crucial role in the prognostic outcome after acute myocardial infarction (AMI by ligation of left-coronary-artery) in MTDKO mouse.	Tetradecanoylphorbol Acetate	46-49	matrix metallopeptidase 9	Mus musculus	38-43
32638255-7	2020	PMA treatment significantly enhanced both the intracellular and cell surface expression of TLR9, while ATRA alone showed no effect.	Tetradecanoylphorbol Acetate	0-3	toll like receptor 9	Homo sapiens	91-95
32673443-7	2020	We collected the conditioned medium from lipopolysaccharide-activated phorbol myristate acetate-induced THP1 (M1) cells to stimulate A549 and H1299 cells and observed that THP1-M1 upregulated SOD-2 by secreting TNF-alpha.	Tetradecanoylphorbol Acetate	70-95	superoxide dismutase 2	Homo sapiens	192-197
32580281-5	2020	We explored PKC-dependent regulation of TRPM8 using Phorbol 12-Myristate 13-Acetate to activate this kinase.	Tetradecanoylphorbol Acetate	52-83	transient receptor potential cation channel subfamily M member 8	Homo sapiens	40-45
32780686-0	2020	Role of E2F1/SPHK1 and HSP27 During Irradiation in a PMA-Induced Inflammatory Model.	Tetradecanoylphorbol Acetate	53-56	heat shock protein family B (small) member 2	Homo sapiens	23-28
32505192-9	2020	Subsequently, PMA induced MMP-9 expression via PKCdelta-mediated reactive oxygen species (ROS) generation, extracellular signal-regulated kinase 1/2 (ERK1/2) activation, and then induced c-Fos/AP-1 signaling pathway.	Tetradecanoylphorbol Acetate	14-17	mitogen activated protein kinase 3	Rattus norvegicus	107-148
32505192-9	2020	Subsequently, PMA induced MMP-9 expression via PKCdelta-mediated reactive oxygen species (ROS) generation, extracellular signal-regulated kinase 1/2 (ERK1/2) activation, and then induced c-Fos/AP-1 signaling pathway.	Tetradecanoylphorbol Acetate	14-17	mitogen activated protein kinase 3	Rattus norvegicus	150-156
32505192-9	2020	Subsequently, PMA induced MMP-9 expression via PKCdelta-mediated reactive oxygen species (ROS) generation, extracellular signal-regulated kinase 1/2 (ERK1/2) activation, and then induced c-Fos/AP-1 signaling pathway.	Tetradecanoylphorbol Acetate	14-17	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	193-197
29414524-10	2018	Furthermore, phorbol 12-myristate 13-acetate (PMA) decreased the expressions of GABAA subunits alpha1, gamma2, and delta when administered alone.	Tetradecanoylphorbol Acetate	13-44	crystallin, gamma E	Rattus norvegicus	95-120
32735617-8	2020	Furthermore, similar to TPA-mediated lytic replication of Kaposi"s sarcoma-associated herpesvirus, IL16 deficiency markedly induces Tyr705 STAT3 de-phosphorylation and elevates p21 expression, which can be counteracted by the tyrosine phosphatase inhibitor orthovanadate.	Tetradecanoylphorbol Acetate	24-27	interleukin 16	Homo sapiens	99-103
29414524-10	2018	Furthermore, phorbol 12-myristate 13-acetate (PMA) decreased the expressions of GABAA subunits alpha1, gamma2, and delta when administered alone.	Tetradecanoylphorbol Acetate	46-49	crystallin, gamma E	Rattus norvegicus	95-120
28950390-7	2018	RESULTS: Phorbol myristate acetate (PMA), a SphK2 stimulator, decreased cell death induced by IC50 of DOX (1.1 microM) to around 70% (p&lt;0.01).	Tetradecanoylphorbol Acetate	9-34	sphingosine kinase 2	Homo sapiens	44-49
32223128-3	2020	Briefly, mesoporous silica materials (MSN) loaded with doxorubicin (DOX) and phorbol 12-myristate 13-acetate (PMA) was used as drug carrier and could be specifically opened by nucleolin in HeLa cell.	Tetradecanoylphorbol Acetate	77-108	nucleolin	Homo sapiens	176-185
32521784-0	2020	Glycogen Synthase Kinase-3beta Facilitates Cytokine Production in 12-O-Tetradecanoylphorbol-13-Acetate/Ionomycin-Activated Human CD4+ T Lymphocytes.	Tetradecanoylphorbol Acetate	66-102	glycogen synthase kinase 3 beta	Homo sapiens	0-30
32223128-3	2020	Briefly, mesoporous silica materials (MSN) loaded with doxorubicin (DOX) and phorbol 12-myristate 13-acetate (PMA) was used as drug carrier and could be specifically opened by nucleolin in HeLa cell.	Tetradecanoylphorbol Acetate	110-113	nucleolin	Homo sapiens	176-185
32223128-4	2020	PMA then induce HeLa cell to produce reactive oxygen species (ROS) and realize ECL imaging of nucleolin.	Tetradecanoylphorbol Acetate	0-3	nucleolin	Homo sapiens	94-103
28950390-7	2018	RESULTS: Phorbol myristate acetate (PMA), a SphK2 stimulator, decreased cell death induced by IC50 of DOX (1.1 microM) to around 70% (p&lt;0.01).	Tetradecanoylphorbol Acetate	36-39	sphingosine kinase 2	Homo sapiens	44-49
32423907-5	2020	RNA sequencing of HB SCs isolated from short-term DMBA/TPA-treated skin showed alpha3beta1-dependent expression of the matricellular protein connective tissue growth factor (CCN2), which was confirmed in vitro, where CCN2 promoted colony formation and 3D growth of transformed keratinocytes.	Tetradecanoylphorbol Acetate	55-58	cellular communication network factor 2	Mus musculus	141-172
31938102-5	2018	Furthermore, we employed rat anterior pituitary GH3 cells as the experiment model to demonstrate that PKCdelta activation by PKC agonist (Phorbol-12-myristate-13-acetate, PMA) significantly promoted the proliferation and migration potential of GH3 cells, and these effects could be abolished following PKCdelta inhibition by specific inhibitor Rottlerin.	Tetradecanoylphorbol Acetate	138-169	protein kinase C, delta	Rattus norvegicus	102-110
31938102-5	2018	Furthermore, we employed rat anterior pituitary GH3 cells as the experiment model to demonstrate that PKCdelta activation by PKC agonist (Phorbol-12-myristate-13-acetate, PMA) significantly promoted the proliferation and migration potential of GH3 cells, and these effects could be abolished following PKCdelta inhibition by specific inhibitor Rottlerin.	Tetradecanoylphorbol Acetate	138-169	protein kinase C delta	Homo sapiens	102-105
31938102-5	2018	Furthermore, we employed rat anterior pituitary GH3 cells as the experiment model to demonstrate that PKCdelta activation by PKC agonist (Phorbol-12-myristate-13-acetate, PMA) significantly promoted the proliferation and migration potential of GH3 cells, and these effects could be abolished following PKCdelta inhibition by specific inhibitor Rottlerin.	Tetradecanoylphorbol Acetate	138-169	protein kinase C, delta	Rattus norvegicus	302-310
32113707-4	2020	SB-216763 inhibited agonist- and phorbol myristate acetate (PMA)-mediated alpha1A-AR phosphorylation, reduced oxymetazoline-induced desensitization, and magnified that induced by PMA.	Tetradecanoylphorbol Acetate	33-58	adrenoceptor alpha 1A	Homo sapiens	74-84
32113707-4	2020	SB-216763 inhibited agonist- and phorbol myristate acetate (PMA)-mediated alpha1A-AR phosphorylation, reduced oxymetazoline-induced desensitization, and magnified that induced by PMA.	Tetradecanoylphorbol Acetate	60-63	adrenoceptor alpha 1A	Homo sapiens	74-84
32113707-7	2020	alpha1A-AR with the GSK3 putative target sites mutated to alanine exhibited reduced phosphorylation and internalization in response to agonists and increased PMA-induced desensitization.	Tetradecanoylphorbol Acetate	158-161	adrenoceptor alpha 1A	Homo sapiens	0-10
32423907-5	2020	RNA sequencing of HB SCs isolated from short-term DMBA/TPA-treated skin showed alpha3beta1-dependent expression of the matricellular protein connective tissue growth factor (CCN2), which was confirmed in vitro, where CCN2 promoted colony formation and 3D growth of transformed keratinocytes.	Tetradecanoylphorbol Acetate	55-58	cellular communication network factor 2	Mus musculus	174-178
32423907-5	2020	RNA sequencing of HB SCs isolated from short-term DMBA/TPA-treated skin showed alpha3beta1-dependent expression of the matricellular protein connective tissue growth factor (CCN2), which was confirmed in vitro, where CCN2 promoted colony formation and 3D growth of transformed keratinocytes.	Tetradecanoylphorbol Acetate	55-58	cellular communication network factor 2	Mus musculus	217-221
29267213-6	2017	PA treatment inhibited the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on upregulation of ERK1/2 activation, MMP-2 expression, cellular migration, and invasion of HeLa cells.	Tetradecanoylphorbol Acetate	37-73	matrix metallopeptidase 2	Homo sapiens	118-123
31893611-8	2020	Taken together, our findings indicated that ML attenuated the TPA-stimulated invasion and migration of MCF-7 cells by suppressing the phosphorylation of ERK and its downstream factors, AP-1 and STAT3.	Tetradecanoylphorbol Acetate	62-65	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	185-189
29267213-6	2017	PA treatment inhibited the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on upregulation of ERK1/2 activation, MMP-2 expression, cellular migration, and invasion of HeLa cells.	Tetradecanoylphorbol Acetate	75-78	matrix metallopeptidase 2	Homo sapiens	118-123
33005592-8	2020	P-PD increased TSLP production in keratinocytes (KCMH-1 cells and phorbol 12-myristate 13-acetate-stimulated PAM212 cells).	Tetradecanoylphorbol Acetate	66-97	thymic stromal lymphopoietin	Mus musculus	15-19
32300280-7	2020	Combination of Vincristine with TPA/GSK126, a drug combination shown to induce differentiation of RMS cell lines, is able to partially overcome MYOD1/NOG cells chemoresistance.	Tetradecanoylphorbol Acetate	32-35	noggin	Homo sapiens	150-153
32074974-8	2020	These results present a novel mechanism showing that CTR-GNPs can attenuate the migration and invasion of glioblastoma cells induced by PMA through transcriptional and translational regulation of MMP-2/-9 and PLD1.	Tetradecanoylphorbol Acetate	136-139	matrix metallopeptidase 2	Homo sapiens	196-204
29177329-4	2017	FDPP-TPA nanoparticles (NPs) obtained by re-precipitation exhibit a high molar extinction coefficient (epsilon = 2.13 (+-0.2) x 104 M-1 cm-1), excellent photothermal conversion efficiency (eta = 47%) and favorable singlet oxygen quantum yield (PhiDelta(X) = 40%).	Tetradecanoylphorbol Acetate	5-8	endothelin receptor type A	Homo sapiens	189-192
31979064-4	2020	In BC models, the phorbol ester 12-myristate 13-acetate (PMA)-mediated activation of protein kinase C (PKC) induced a down-regulation of CAXII with a concomitant modulation of other members of the transport metabolon, including CAIX and the sodium bicarbonate cotransporter 3 (NBCn1).	Tetradecanoylphorbol Acetate	57-60	carbonic anhydrase 12	Homo sapiens	137-142
31979064-4	2020	In BC models, the phorbol ester 12-myristate 13-acetate (PMA)-mediated activation of protein kinase C (PKC) induced a down-regulation of CAXII with a concomitant modulation of other members of the transport metabolon, including CAIX and the sodium bicarbonate cotransporter 3 (NBCn1).	Tetradecanoylphorbol Acetate	57-60	carbonic anhydrase 9	Homo sapiens	228-232
31979064-4	2020	In BC models, the phorbol ester 12-myristate 13-acetate (PMA)-mediated activation of protein kinase C (PKC) induced a down-regulation of CAXII with a concomitant modulation of other members of the transport metabolon, including CAIX and the sodium bicarbonate cotransporter 3 (NBCn1).	Tetradecanoylphorbol Acetate	57-60	solute carrier family 4 member 7	Homo sapiens	241-275
28513986-3	2017	Deactivation of the Focal Adhesion Kinase (FAK) by FFA contributes to glucose transport impairment, and could be corrected by chronic treatment with the phorbol ester TPA.	Tetradecanoylphorbol Acetate	167-170	protein tyrosine kinase 2	Homo sapiens	20-41
31939617-0	2020	Inhibition of TPA-induced metastatic potential by morin hydrate in MCF-7 human breast cancer cells via the Akt/GSK-3beta/c-Fos signaling pathway.	Tetradecanoylphorbol Acetate	14-17	glycogen synthase kinase 3 alpha	Homo sapiens	111-120
28513986-3	2017	Deactivation of the Focal Adhesion Kinase (FAK) by FFA contributes to glucose transport impairment, and could be corrected by chronic treatment with the phorbol ester TPA.	Tetradecanoylphorbol Acetate	167-170	protein tyrosine kinase 2	Homo sapiens	43-46
28513986-7	2017	TPA markedly downregulated the expression of PKCalpha, PKCdelta, and PKCepsilon, suggesting that PKCdelta or PKCepsilon activation could contribute to inhibition of glucose transport by FFA.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	55-63
28513986-7	2017	TPA markedly downregulated the expression of PKCalpha, PKCdelta, and PKCepsilon, suggesting that PKCdelta or PKCepsilon activation could contribute to inhibition of glucose transport by FFA.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	97-105
32997559-8	2020	Neutrophil activation using phorbol myristate acetate (PMA) and zymosan dose-dependently caused DAO concentrations to be elevated more than 10-fold at both 22 C and 37 C (both P-values <0.001).	Tetradecanoylphorbol Acetate	28-53	amine oxidase copper containing 1	Homo sapiens	96-99
28513986-8	2017	Rottlerin, a specific PKCdelta inhibitor, improved glucose transport in FFA-exposed cardiomyocytes; and PKCdelta was reduced in the particulate fraction of FFA + TPA-exposed cardiomyocytes.	Tetradecanoylphorbol Acetate	162-165	protein kinase C delta	Homo sapiens	104-112
28993517-6	2017	FoxN1 expression inversely correlated with the fraction of slow cycling and apoptotic cells within the four TPA subsets.	Tetradecanoylphorbol Acetate	108-111	forkhead box N1	Homo sapiens	0-5
31979064-4	2020	In BC models, the phorbol ester 12-myristate 13-acetate (PMA)-mediated activation of protein kinase C (PKC) induced a down-regulation of CAXII with a concomitant modulation of other members of the transport metabolon, including CAIX and the sodium bicarbonate cotransporter 3 (NBCn1).	Tetradecanoylphorbol Acetate	57-60	solute carrier family 4 member 7	Homo sapiens	277-282
32997559-8	2020	Neutrophil activation using phorbol myristate acetate (PMA) and zymosan dose-dependently caused DAO concentrations to be elevated more than 10-fold at both 22 C and 37 C (both P-values <0.001).	Tetradecanoylphorbol Acetate	55-58	amine oxidase copper containing 1	Homo sapiens	96-99
30580605-8	2020	ST8 exhibited significant anti-inflammatory activity against TPA-induced skin inflammation without any skin irritation effect on experimental animals.	Tetradecanoylphorbol Acetate	61-64	Oncogene OVC (ovarian adenocarcinoma oncogene)	Homo sapiens	0-3
31732450-4	2019	We also observed suppressive effects on the expression of CD69, with 30 muM BAY causing 3.55-fold lower expression than PMA/ionomycin (p &lt; 0.001 one-way ANOVA followed by Tukey"s test), and T-bet, with 30 muM BAY causing 1.47-fold lower expression than PMA/ionomycin (p &lt; 0.05, one-way ANOVA test followed by Tukey"s test).	Tetradecanoylphorbol Acetate	120-123	CD69 molecule	Homo sapiens	58-62
31732450-4	2019	We also observed suppressive effects on the expression of CD69, with 30 muM BAY causing 3.55-fold lower expression than PMA/ionomycin (p &lt; 0.001 one-way ANOVA followed by Tukey"s test), and T-bet, with 30 muM BAY causing 1.47-fold lower expression than PMA/ionomycin (p &lt; 0.05, one-way ANOVA test followed by Tukey"s test).	Tetradecanoylphorbol Acetate	256-259	CD69 molecule	Homo sapiens	58-62
29149784-0	2017	Anti-inflammatory Property of beta-D-Mannuronic Acid (M2000) on Expression and Activity of Matrix Metalloproteinase-2 and -9 through CD147 Molecule in Phorbol Myristate Acetate-differentiated THP-1 Cells.	Tetradecanoylphorbol Acetate	151-176	matrix metallopeptidase 2	Homo sapiens	91-124
31561854-7	2019	PMA induced CD14+ differentiation of leukemia cells, whereas HMA induced cell cycle arrest at the G1 phase.	Tetradecanoylphorbol Acetate	0-3	CD14 molecule	Homo sapiens	12-16
31855322-8	2019	In unstimulated and CCL19-treated CD4+ T cells, expression of the GFP latent reporter, increased after further activation of the cells with PHA/phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	144-175	C-C motif chemokine ligand 19	Homo sapiens	20-25
31855322-8	2019	In unstimulated and CCL19-treated CD4+ T cells, expression of the GFP latent reporter, increased after further activation of the cells with PHA/phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	177-180	C-C motif chemokine ligand 19	Homo sapiens	20-25
31264895-12	2019	Neutrophils induced to form neutrophil extracellular traps (NETs) with phorbol myristate acetate (PMA) released high concentrations of PZP in-vitro, and fluorescence microscopy confirmed the presence of PZP in NETs, while fluorescence and electron microscopy localised PZP to the cytoplasm and nuclei of neutrophils.	Tetradecanoylphorbol Acetate	71-96	PZP alpha-2-macroglobulin like	Homo sapiens	135-138
31496351-9	2019	PMA-induced NETosis directly upregulated the TLR9/NF-kappaB pathway in macrophages and subsequently initiated the release of IL-8.	Tetradecanoylphorbol Acetate	0-3	toll like receptor 9	Homo sapiens	45-49
29090275-0	2017	Activation of TPA-response element present in human Lemur Tyrosine Kinase 2 (lmtk2) gene increases its expression.	Tetradecanoylphorbol Acetate	14-17	lemur tyrosine kinase 2	Homo sapiens	52-75
29090275-0	2017	Activation of TPA-response element present in human Lemur Tyrosine Kinase 2 (lmtk2) gene increases its expression.	Tetradecanoylphorbol Acetate	14-17	lemur tyrosine kinase 2	Homo sapiens	77-82
29090275-6	2017	Interestingly, the human lmtk2 gene contains a consensus TPA (12- O-Tetradecanoylphorbol-13-acetate)-responsive element (TRE) in the region preceding its start codon.	Tetradecanoylphorbol Acetate	57-60	lemur tyrosine kinase 2	Homo sapiens	25-30
29090275-6	2017	Interestingly, the human lmtk2 gene contains a consensus TPA (12- O-Tetradecanoylphorbol-13-acetate)-responsive element (TRE) in the region preceding its start codon.	Tetradecanoylphorbol Acetate	62-99	lemur tyrosine kinase 2	Homo sapiens	25-30
29090275-7	2017	The element with the sequence TGAGTCA modulates LMTK2 expression in response to treatment with TPA, a synthetic Protein Kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	95-98	lemur tyrosine kinase 2	Homo sapiens	48-53
29090275-9	2017	We observed that TPA, at low concentrations, increases the promoter activity of LMTK2, which leads to a subsequent increase in the mRNA transcript and protein levels.	Tetradecanoylphorbol Acetate	17-20	lemur tyrosine kinase 2	Homo sapiens	80-85
31206174-5	2019	Further investigation demonstrated that A20 reduces interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha production in CD56bright NK cells after stimulation with monokines or phorbol myristate acetate (PMA)/ionomycin(P/I).	Tetradecanoylphorbol Acetate	184-209	TNF alpha induced protein 3	Homo sapiens	40-43
31206174-5	2019	Further investigation demonstrated that A20 reduces interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha production in CD56bright NK cells after stimulation with monokines or phorbol myristate acetate (PMA)/ionomycin(P/I).	Tetradecanoylphorbol Acetate	211-214	TNF alpha induced protein 3	Homo sapiens	40-43
29090275-11	2017	Thus, our current study has established LMTK2 as a TPA-responsive element-containing gene, which is upregulated downstream of PKC activation.	Tetradecanoylphorbol Acetate	51-54	lemur tyrosine kinase 2	Homo sapiens	40-45
31264895-12	2019	Neutrophils induced to form neutrophil extracellular traps (NETs) with phorbol myristate acetate (PMA) released high concentrations of PZP in-vitro, and fluorescence microscopy confirmed the presence of PZP in NETs, while fluorescence and electron microscopy localised PZP to the cytoplasm and nuclei of neutrophils.	Tetradecanoylphorbol Acetate	98-101	PZP alpha-2-macroglobulin like	Homo sapiens	135-138
28970848-10	2017	CONCLUSION: The results indicated that the inhibitory effects of CFE against TPA-induced MMP-9 expression and MCF-7 cell invasion were dependent on the protein kinase C delta/p38/c-Jun N-terminal kinase/AP-1 pathway.	Tetradecanoylphorbol Acetate	77-80	protein kinase C delta	Homo sapiens	152-174
31264895-12	2019	Neutrophils induced to form neutrophil extracellular traps (NETs) with phorbol myristate acetate (PMA) released high concentrations of PZP in-vitro, and fluorescence microscopy confirmed the presence of PZP in NETs, while fluorescence and electron microscopy localised PZP to the cytoplasm and nuclei of neutrophils.	Tetradecanoylphorbol Acetate	98-101	PZP alpha-2-macroglobulin like	Homo sapiens	203-206
31264895-12	2019	Neutrophils induced to form neutrophil extracellular traps (NETs) with phorbol myristate acetate (PMA) released high concentrations of PZP in-vitro, and fluorescence microscopy confirmed the presence of PZP in NETs, while fluorescence and electron microscopy localised PZP to the cytoplasm and nuclei of neutrophils.	Tetradecanoylphorbol Acetate	98-101	PZP alpha-2-macroglobulin like	Homo sapiens	203-206
31749866-3	2019	The objective of this study was to investigate whether FHx is associated with a higher atherosclerotic burden, measured as carotid total plaque area (TPA) in a population having no traditional RF.	Tetradecanoylphorbol Acetate	150-153	forkhead box J2	Homo sapiens	55-58
27717886-6	2017	Also, TPA-dependent PR activation increases the expression of progesterone-induced blocking factor (PIBF), a known PR target gene.	Tetradecanoylphorbol Acetate	6-9	progesterone immunomodulatory binding factor 1	Homo sapiens	62-98
27717886-6	2017	Also, TPA-dependent PR activation increases the expression of progesterone-induced blocking factor (PIBF), a known PR target gene.	Tetradecanoylphorbol Acetate	6-9	progesterone immunomodulatory binding factor 1	Homo sapiens	100-104
31362059-3	2019	IL-9 secretion was undetectable in CD8+ T cells ex vivo, but could be readily detected following anti-TCR or PMA + ionomycin stimulation, and was higher in breast cancer patients than in healthy controls.	Tetradecanoylphorbol Acetate	109-112	interleukin 9	Homo sapiens	0-4
31749866-6	2019	Compared to 56 matched controls TPA was 86% higher in FHx patients (p < 0.05).	Tetradecanoylphorbol Acetate	32-35	forkhead box J2	Homo sapiens	54-57
28827622-8	2017	In contrast, activation of the PKC protein family by 4beta-phorbol 12-myristate 13-acetate (PMA) did not accelerate collagen gel contraction although it induced long-term cofilin de-phosphorylation, showing the need of a dynamic control of cofilin de-phosphorylation for PDGF-enhanced collagen gel contraction.	Tetradecanoylphorbol Acetate	92-95	cofilin 1	Homo sapiens	171-178
31749866-8	2019	Results: Compared with 44 matched controls, TPA was 77% higher in FHx patients (p < 0.05).	Tetradecanoylphorbol Acetate	44-47	forkhead box J2	Homo sapiens	66-69
31432148-2	2019	Certain 5" upstream regions of the zinc finger protein (ZNF)-encoding genes contain duplicated GGAA motifs, which are frequently found in the TPA-responding gene promoter regions.	Tetradecanoylphorbol Acetate	142-145	zinc finger protein 763	Homo sapiens	35-54
31749866-9	2019	A final analysis using a generalized linear model with TPA progression as the response variable suggests that TPA progresses more rapidly in FHx patients compared to controls.	Tetradecanoylphorbol Acetate	55-58	forkhead box J2	Homo sapiens	141-144
31432148-2	2019	Certain 5" upstream regions of the zinc finger protein (ZNF)-encoding genes contain duplicated GGAA motifs, which are frequently found in the TPA-responding gene promoter regions.	Tetradecanoylphorbol Acetate	142-145	zinc finger protein 763	Homo sapiens	56-59
31749866-9	2019	A final analysis using a generalized linear model with TPA progression as the response variable suggests that TPA progresses more rapidly in FHx patients compared to controls.	Tetradecanoylphorbol Acetate	110-113	forkhead box J2	Homo sapiens	141-144
31749866-10	2019	Conclusions: The FHx was associated with increased TPA burden and progression in the absence of other TRF.	Tetradecanoylphorbol Acetate	51-54	forkhead box J2	Homo sapiens	17-20
28539358-7	2017	Phorbol 12-myristate 13-acetate stimulation of both cell types revealed that PKCepsilon positively regulates beta-catenin expression and stabilization in a glycogen synthase kinase 3beta-independent manner.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, epsilon	Mus musculus	77-87
31351099-8	2019	Consequently, DA significantly reduced the production of NF-kappaB and COX-2 induced proinflammatory cytokine levels on TPA induced ear edema.	Tetradecanoylphorbol Acetate	120-123	cytochrome c oxidase II, mitochondrial	Mus musculus	71-76
28512205-0	2017	Phorbol-12-myristate-13-acetate-mediated stabilization of leukemia inhibitory factor (lif) mRNA: involvement of Nucleolin and PCBP1.	Tetradecanoylphorbol Acetate	0-31	nucleolin	Homo sapiens	112-121
28512205-5	2017	Affinity chromatography followed by western blot and RNA co-immunoprecipitation of PMA-treated U937 extract identified Nucleolin and PCBP1 as two protein trans-factors interacting with lif mRNA, specifically to the proximal non-conventional AU-rich region.	Tetradecanoylphorbol Acetate	83-86	nucleolin	Homo sapiens	119-128
31695569-8	2019	Results: RG products potently inhibited IL-4 expression in phorbol 12-myristate-13-acetate/A23187-stimulated RBL-2H3 cells.	Tetradecanoylphorbol Acetate	59-90	interleukin 4	Rattus norvegicus	40-44
31361289-6	2019	Furthermore, in a tetradecanoylphorbolacetate (TPA)-treated mouse model, AA and IA could effectively attenuate mouse ear edema and pathological damage and reduced levels of cytokines including iNOS, COX-2, TNF-alpha, and IL-1beta.	Tetradecanoylphorbol Acetate	47-50	cytochrome c oxidase II, mitochondrial	Mus musculus	199-204
28512205-6	2017	PMA induced nucleo-cytoplasmic translocation of both Nucleolin and PCBP1.	Tetradecanoylphorbol Acetate	0-3	nucleolin	Homo sapiens	53-62
31390749-8	2019	This carnosine antioxidant activity was accompanied by the attenuation of the PMA-induced Akt phosphorylation, the down-regulation of TNF-alpha and IL-6 mRNAs, and the up-regulation of the expression of the anti-inflammatory mediators IL-4, IL-10, and TGF-beta1.	Tetradecanoylphorbol Acetate	78-81	transforming growth factor, beta 1	Mus musculus	252-261
31016559-2	2019	In response to treatment with Man3-DPPE-coated liposomes (Man3-OMLs), PMA-stimulated human THP-1 cells showed enhanced expression of CD40, CD80 and HLA-DR and secreted significant levels of IL-12p40.	Tetradecanoylphorbol Acetate	70-73	CD40 molecule	Homo sapiens	133-137
28259684-0	2017	Ablation of Ctip2/Bcl11b in Adult Epidermis Enhances TPA/UV-Induced Proliferation and Increases Susceptibility to DMBA/TPA-Induced Epidermal Carcinogenesis.	Tetradecanoylphorbol Acetate	53-56	BAF chromatin remodeling complex subunit BCL11B	Homo sapiens	12-17
28259684-0	2017	Ablation of Ctip2/Bcl11b in Adult Epidermis Enhances TPA/UV-Induced Proliferation and Increases Susceptibility to DMBA/TPA-Induced Epidermal Carcinogenesis.	Tetradecanoylphorbol Acetate	53-56	BAF chromatin remodeling complex subunit BCL11B	Homo sapiens	18-24
28259684-0	2017	Ablation of Ctip2/Bcl11b in Adult Epidermis Enhances TPA/UV-Induced Proliferation and Increases Susceptibility to DMBA/TPA-Induced Epidermal Carcinogenesis.	Tetradecanoylphorbol Acetate	119-122	BAF chromatin remodeling complex subunit BCL11B	Homo sapiens	12-17
28259684-0	2017	Ablation of Ctip2/Bcl11b in Adult Epidermis Enhances TPA/UV-Induced Proliferation and Increases Susceptibility to DMBA/TPA-Induced Epidermal Carcinogenesis.	Tetradecanoylphorbol Acetate	119-122	BAF chromatin remodeling complex subunit BCL11B	Homo sapiens	18-24
31002911-11	2019	In addition, phorbol-12-myristate-13-acetate (PMA, a activator of PKC) markedly attenuated the suppressive effects of propofol on ERK1/2 phosphorylation and NSC proliferation.	Tetradecanoylphorbol Acetate	13-44	mitogen activated protein kinase 3	Rattus norvegicus	130-136
31002911-11	2019	In addition, phorbol-12-myristate-13-acetate (PMA, a activator of PKC) markedly attenuated the suppressive effects of propofol on ERK1/2 phosphorylation and NSC proliferation.	Tetradecanoylphorbol Acetate	46-49	mitogen activated protein kinase 3	Rattus norvegicus	130-136
31216771-7	2019	Biological data revealed that SP6 has a significant protective action against the neurotoxic action of 6-hydroxydopamine (6-OHDA) and H2O2 in a RA/PMA-differentiated SY-SH5Y neuroblastoma cell line that proved to be an effective antioxidant and protective compound.	Tetradecanoylphorbol Acetate	147-150	Sp6 transcription factor	Homo sapiens	30-33
28511091-4	2017	Both free and cell surface rhesus macaque DNGR-1 expressed in vitro could bind to apoptotic/dead cells induced by serum deprivation or freeze-thaw, and to pyroptotic cells stimulated with PMA and LPS.	Tetradecanoylphorbol Acetate	188-191	C-type lectin domain containing 9A	Homo sapiens	42-48
31016559-2	2019	In response to treatment with Man3-DPPE-coated liposomes (Man3-OMLs), PMA-stimulated human THP-1 cells showed enhanced expression of CD40, CD80 and HLA-DR and secreted significant levels of IL-12p40.	Tetradecanoylphorbol Acetate	70-73	CD80 molecule	Homo sapiens	139-143
30219864-6	2019	Nonetheless, overexpression of WT-SMAD7 caused a susceptibility to 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperproliferation through activation of epidermal growth factor (EGF) signaling.	Tetradecanoylphorbol Acetate	67-103	SMAD family member 7	Mus musculus	34-39
28389297-4	2017	Accordingly, in HAP1 FBXO25 knockout cells (FBXO25KO), we observed that upon PMA treatment ERK1/2 was more active than in parental cells.	Tetradecanoylphorbol Acetate	77-80	F-box protein 25	Homo sapiens	21-27
30394679-4	2019	Phorbol esters (PMA) are known to induce de novo PLVAP expression and diaphragm formation.	Tetradecanoylphorbol Acetate	16-19	plasmalemma vesicle associated protein	Homo sapiens	49-54
28013489-1	2017	RSK2 is a serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90RSK; RSKs) family, which regulates cell proliferation and transformation induced by tumor promoters such as epithelial growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate (TPA), and ultraviolet (UV) radiation.	Tetradecanoylphorbol Acetate	222-258	ribosomal protein S6 kinase A3	Homo sapiens	0-4
28013489-1	2017	RSK2 is a serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90RSK; RSKs) family, which regulates cell proliferation and transformation induced by tumor promoters such as epithelial growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate (TPA), and ultraviolet (UV) radiation.	Tetradecanoylphorbol Acetate	260-263	ribosomal protein S6 kinase A3	Homo sapiens	0-4
31199460-0	2019	Characterization of the human E2F4 promoter region and its response to 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	71-107	E2F transcription factor 4	Homo sapiens	30-34
31199460-5	2019	The transfection of this plasmid and deletion/mutation-introduced derivatives into HL-60 cells and a Luc reporter assay showed that duplicated and triplicated GGAA (TTCC) motifs in the E2F4 promoter respond to TPA.	Tetradecanoylphorbol Acetate	210-213	E2F transcription factor 4	Homo sapiens	185-189
30579151-10	2019	In these patients, the tPA-ROTEM results depended on FII, FXII, plasminogen, alpha2-antiplasmin, PAI-1 and TAFI levels.	Tetradecanoylphorbol Acetate	23-26	carboxypeptidase B2	Homo sapiens	107-111
30953781-8	2019	Meanwhile, protein level of H-Ras was also augmented once leukocytes were stimulated with lymphocyte receptor signaling agonist PMA and ionomycin.	Tetradecanoylphorbol Acetate	128-131	GTPase HRas	Oreochromis niloticus	28-33
27927723-11	2017	Prevention of ERK1/2 signaling by using a MEK1 inhibitor caused a marked decreased in phorbol 12-myristate 13-acetate-induced mitochondrial respiration.	Tetradecanoylphorbol Acetate	86-117	mitogen activated protein kinase 3	Rattus norvegicus	14-20
27927723-11	2017	Prevention of ERK1/2 signaling by using a MEK1 inhibitor caused a marked decreased in phorbol 12-myristate 13-acetate-induced mitochondrial respiration.	Tetradecanoylphorbol Acetate	86-117	mitogen activated protein kinase kinase 1	Rattus norvegicus	42-46
30481548-2	2019	We demonstrated that Gal-3 expression was significantly induced by tumor necrosis factor (TNF)-alpha or phorbol 12-myristate 13-acetate in OM-10.1 and ACH-2 cells, which are considered as a model of HIV-1 latently infected cells.	Tetradecanoylphorbol Acetate	104-135	galectin 3	Homo sapiens	21-26
28098879-9	2017	PMA potently stimulated MMP-9 and had a moderate effect on MMP-2.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 2	Homo sapiens	59-64
31151753-8	2019	Either forskolin or phorbol 12 myristate 13-acetate can mimic hCG induction of Kctd11 expression.	Tetradecanoylphorbol Acetate	20-51	hypertrichosis 2 (generalised, congenital)	Homo sapiens	62-65
30645596-4	2019	Phorbol-12-myristate-13-acetate (PMA), a PKCalpha activator, significantly increased the activity and expression of matrix metalloproteinases (MMP) -2 and -9 in human (late outgrowth) EPCs in vitro.	Tetradecanoylphorbol Acetate	0-31	matrix metallopeptidase 2	Homo sapiens	116-157
30967259-6	2019	In both control and HG cultured beta cells, deficiency of Hv1 decreased the glucose- and PMA-induced ROS production.	Tetradecanoylphorbol Acetate	89-92	hydrogen voltage gated channel 1	Homo sapiens	58-61
28061416-6	2017	Furthermore, PKC activation treated with PMA could obviously up-regulate the expression of alpha-SMA and collagen I and the phosphorylation of GSK3beta, while inhibition of PKC significantly reduced GSK3beta activation.	Tetradecanoylphorbol Acetate	41-44	glycogen synthase kinase 3 beta	Homo sapiens	143-151
28286738-4	2017	Treatment with phorbol-12-myristate-13-acetate (PMA), a potent agonist of protein kinase C (PKC) and its downstream effector in the MEK/ERK-dependent pathway, resulted in the activation of mTORC1 signaling and phosphorylation of the upstream regulator tuberous sclerosis 2 (TSC2) in C2C12 myoblasts.	Tetradecanoylphorbol Acetate	15-46	CREB regulated transcription coactivator 1	Mus musculus	189-195
28286738-4	2017	Treatment with phorbol-12-myristate-13-acetate (PMA), a potent agonist of protein kinase C (PKC) and its downstream effector in the MEK/ERK-dependent pathway, resulted in the activation of mTORC1 signaling and phosphorylation of the upstream regulator tuberous sclerosis 2 (TSC2) in C2C12 myoblasts.	Tetradecanoylphorbol Acetate	48-51	CREB regulated transcription coactivator 1	Mus musculus	189-195
30645596-4	2019	Phorbol-12-myristate-13-acetate (PMA), a PKCalpha activator, significantly increased the activity and expression of matrix metalloproteinases (MMP) -2 and -9 in human (late outgrowth) EPCs in vitro.	Tetradecanoylphorbol Acetate	33-36	matrix metallopeptidase 2	Homo sapiens	116-157
28286738-5	2017	PMA-induced activation of mTORC1 signaling was partially prevented by treatment with U0126 (a selective inhibitor of MEK1/2) or BIX-02189 (a selective inhibitor of MEK5) and completely blocked with BIM-I (a selective inhibitor of upstream PKC).	Tetradecanoylphorbol Acetate	0-3	CREB regulated transcription coactivator 1	Mus musculus	26-32
30444039-6	2019	The inhibition of CerK reduced the phorbol 12-myristate 13-acetate-induced translocation of SphK1 to the plasma membrane (PM) and activation of the enzyme in membrane fractions of cells.	Tetradecanoylphorbol Acetate	35-66	ceramide kinase	Homo sapiens	18-22
30645596-11	2019	PMA could activate PKCalpha and promote the angiogenesis capacity of human EPCs via NADPH oxidase-mediated, redox-related, MMP-2 and MMP-9 pathways.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 2	Homo sapiens	123-128
31026389-0	2019	Praeruptorin-B Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Invasion by Targeting AKT/NF-kappaB via Matrix Metalloproteinase-2/-9 Expression in Human Cervical Cancer Cells.	Tetradecanoylphorbol Acetate	24-60	matrix metallopeptidase 2	Homo sapiens	114-143
30921339-7	2019	Phorbol ester 12-O-tetradecanoylphorbol-13-acetate (PMA), a PKC activator, up-regulated FGF23 production.	Tetradecanoylphorbol Acetate	14-50	fibroblast growth factor 23	Rattus norvegicus	88-93
27693558-4	2016	We show that TPA treatment activates MEK1, ERK1/2 and downstream effector AP-1 in wild-type (WT) epidermal cells and mice, but not in cells or mice where Lgr4 is depleted.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase kinase 1	Mus musculus	37-41
27693558-4	2016	We show that TPA treatment activates MEK1, ERK1/2 and downstream effector AP-1 in wild-type (WT) epidermal cells and mice, but not in cells or mice where Lgr4 is depleted.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 3	Mus musculus	43-49
27693558-6	2016	We provide evidences that blocking both MEK1/ERK1/2 and Wnt/beta-catenin pathways prevents TPA-induced increase in the expression of Ccnd1 (cyclin D1), a known Wnt/beta-catenin target gene, and that the activation of MEK1/ERK1/2 pathway lies upstream of Wnt/beta-catenin signal pathway.	Tetradecanoylphorbol Acetate	91-94	mitogen-activated protein kinase kinase 1	Mus musculus	40-44
31026389-4	2019	Western blotting and RT-PCR were performed to investigate the inhibitory effect of Pra-B on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2/-9 (MMP-2/-9) expression in HeLa cells.	Tetradecanoylphorbol Acetate	92-128	matrix metallopeptidase 2	Homo sapiens	143-172
27693558-6	2016	We provide evidences that blocking both MEK1/ERK1/2 and Wnt/beta-catenin pathways prevents TPA-induced increase in the expression of Ccnd1 (cyclin D1), a known Wnt/beta-catenin target gene, and that the activation of MEK1/ERK1/2 pathway lies upstream of Wnt/beta-catenin signal pathway.	Tetradecanoylphorbol Acetate	91-94	mitogen-activated protein kinase 3	Mus musculus	45-51
27693558-6	2016	We provide evidences that blocking both MEK1/ERK1/2 and Wnt/beta-catenin pathways prevents TPA-induced increase in the expression of Ccnd1 (cyclin D1), a known Wnt/beta-catenin target gene, and that the activation of MEK1/ERK1/2 pathway lies upstream of Wnt/beta-catenin signal pathway.	Tetradecanoylphorbol Acetate	91-94	mitogen-activated protein kinase kinase 1	Mus musculus	217-221
31026389-4	2019	Western blotting and RT-PCR were performed to investigate the inhibitory effect of Pra-B on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2/-9 (MMP-2/-9) expression in HeLa cells.	Tetradecanoylphorbol Acetate	92-128	matrix metallopeptidase 2	Homo sapiens	174-182
27693558-6	2016	We provide evidences that blocking both MEK1/ERK1/2 and Wnt/beta-catenin pathways prevents TPA-induced increase in the expression of Ccnd1 (cyclin D1), a known Wnt/beta-catenin target gene, and that the activation of MEK1/ERK1/2 pathway lies upstream of Wnt/beta-catenin signal pathway.	Tetradecanoylphorbol Acetate	91-94	mitogen-activated protein kinase 3	Mus musculus	222-228
31026389-4	2019	Western blotting and RT-PCR were performed to investigate the inhibitory effect of Pra-B on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2/-9 (MMP-2/-9) expression in HeLa cells.	Tetradecanoylphorbol Acetate	130-133	matrix metallopeptidase 2	Homo sapiens	143-172
30921339-7	2019	Phorbol ester 12-O-tetradecanoylphorbol-13-acetate (PMA), a PKC activator, up-regulated FGF23 production.	Tetradecanoylphorbol Acetate	52-55	fibroblast growth factor 23	Rattus norvegicus	88-93
31026389-5	2019	The findings of the luciferase assay confirmed the inhibitory effect of Pra-B on TPA-induced transcriptional activity of MMP2/-9 in HeLa cells.	Tetradecanoylphorbol Acetate	81-84	matrix metallopeptidase 2	Homo sapiens	121-125
31026389-7	2019	Pra-B suppressed TPA-induced mRNA and protein expression and transcriptional activity of MMP-2/-9 in HeLa cells.	Tetradecanoylphorbol Acetate	17-20	matrix metallopeptidase 2	Homo sapiens	89-97
27335373-6	2016	We show that human podocytes express uPA and three Plg receptors: uPAR, tPA, and Plg-RKT.	Tetradecanoylphorbol Acetate	72-75	plasminogen	Homo sapiens	51-54
31026389-9	2019	Cotreatment of HeLa cells with TPA plus Pra-B or LY294002 (a PI3K inhibitor) reduced cell invasion and MMP-2/-9 expression and transcriptional activity.	Tetradecanoylphorbol Acetate	31-34	matrix metallopeptidase 2	Homo sapiens	103-111
31026389-12	2019	CONCLUSION: These results suggested that Pra-B-mediated inhibition of TPA-induced cell metastasis involved the suppression of p-AKT/NF-kappaB via MMP-2/-9 expression in HeLa cells.	Tetradecanoylphorbol Acetate	70-73	matrix metallopeptidase 2	Homo sapiens	146-154
30329215-3	2019	Phorbol 12-myristate 13-acetate activation of LFA-1 caused transient cytosolic domain separation.	Tetradecanoylphorbol Acetate	0-31	integrin subunit alpha L	Homo sapiens	46-51
30588093-0	2018	An individual reference limit of the serum CEA-TPA-CA 15-3 tumor marker panel in the surveillance of asymptomatic women following surgery for primary breast cancer.	Tetradecanoylphorbol Acetate	47-50	mucin 1, cell surface associated	Homo sapiens	51-58
30498366-7	2018	This inhibitory effect was associated with the inhibition of TPA-induced upregulation of proinflammatory cytokines IL-1beta, TNF-alpha, and COX-2.	Tetradecanoylphorbol Acetate	61-64	cytochrome c oxidase II, mitochondrial	Mus musculus	140-145
27586664-7	2016	We describe dye uptake, interpreted as connexin dependent, that is shown to be enhanced with reduced extracellular Ca2+, mechanically responsive, inhibited by TPA, inhibited by EL186 antibodies for Cx43 and sustained for more than 15 min following mechanical stimulation.	Tetradecanoylphorbol Acetate	159-162	gap junction protein alpha 1	Homo sapiens	198-202
29905975-4	2018	Stimulation of immortalized rat cardiomyocytes (H9c2) with phorbol 12-myristate 13-acetate (PMA) resulted in up-regulation of Egr-1 and subsequently of Grk2 mRNA expression, with maximum Grk2 expression (p = 0.008) 5 hr after PMA stimulation and being abolished by actinomycin D, indicating a transcriptional mechanism.	Tetradecanoylphorbol Acetate	59-90	G protein-coupled receptor kinase 2	Rattus norvegicus	152-156
30417074-3	2018	During subsequent perfusion culture, lymphangiogenesis and vascular angiogenesis were induced by addition of phorbol 12-myristate 13-acetate (PMA) and VEGF-C or VEGF-A characterized by podoplanin and Prox-1 expression.	Tetradecanoylphorbol Acetate	109-140	prospero homeobox 1	Homo sapiens	200-206
30288224-6	2018	Moreover, GA significantly inhibited the TPA-mediated activation of extracellular signal-regulated kinase (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K)/Akt, which are upstream of nuclear factor-kB (NF-kappaB).	Tetradecanoylphorbol Acetate	41-44	mitogen-activated protein kinase 3	Mus musculus	107-113
29905975-4	2018	Stimulation of immortalized rat cardiomyocytes (H9c2) with phorbol 12-myristate 13-acetate (PMA) resulted in up-regulation of Egr-1 and subsequently of Grk2 mRNA expression, with maximum Grk2 expression (p = 0.008) 5 hr after PMA stimulation and being abolished by actinomycin D, indicating a transcriptional mechanism.	Tetradecanoylphorbol Acetate	59-90	G protein-coupled receptor kinase 2	Rattus norvegicus	187-191
30144443-6	2018	Western Blot analysis of cell lysate showed a drastic TPA induced increase of COX-2 levels, which was not seen with neither PMSG nor forskolin treatment.	Tetradecanoylphorbol Acetate	54-57	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	78-83
29771377-6	2018	MBNL1 knockdown phenocopies several alternative-splicing changes and strongly impairs PMA differentiation, suggesting functional defects in monocytes from Myotonic Dystrophy patients.	Tetradecanoylphorbol Acetate	86-89	muscleblind like splicing regulator 1	Homo sapiens	0-5
29763855-6	2018	Moreover, we have experimentally stimulated the CD23 phosphorylations in a subset of peripheral blood lymphocytes of healthy controls by phorbol-12-myristate-13-acetate treatment.	Tetradecanoylphorbol Acetate	137-168	Fc epsilon receptor II	Homo sapiens	48-52
30486830-9	2018	Reduced expression of ITGAV and TIMP-1 were identified in DMBA/TPA-induced skin tissues of IL-32gamma mice compared to that in WT mice.	Tetradecanoylphorbol Acetate	63-66	integrin alpha V	Mus musculus	22-27
30402027-8	2018	Tussilagone inhibited PMA-induced phosphorylation and nuclear translocation of nuclear factor kappa B (NF-kappaB) p65.	Tetradecanoylphorbol Acetate	22-25	RELA proto-oncogene, NF-kB subunit	Homo sapiens	114-117
29645357-1	2018	Organometallic half-sandwich IrIII complexes of the type [(eta5 -Cpx )Ir(N^N)Cl]PF6 (Cpx : Cp* or its phenyl Cpxph or biphenyl Cpxbiph derivatives; N^N: triphenylamine (TPA)-substituted bipyridyl ligand groups) were synthesized and characterized.	Tetradecanoylphorbol Acetate	169-172	sperm associated antigen 17	Homo sapiens	80-83
30138774-0	2018	Morphologic TPA (mTPA) and composite risk score for moderate carotid atherosclerotic plaque is strongly associated with HbA1c in diabetes cohort.	Tetradecanoylphorbol Acetate	12-15	hemoglobin subunit alpha 1	Homo sapiens	120-124
30596378-13	2018	CCL11 was produced by CD4+ T cells in PBMC after stimulation with PMA and ionomycin for 4-24 h. After LPS stimulation of PBMC, CCL2, CCL5, and CCL11 production were comparable to culture in medium alone.	Tetradecanoylphorbol Acetate	66-69	eotaxin	Equus caballus	0-5
29466706-8	2018	Finally, rTsEnoA-bound Plg was activated to plasmin in the presence of tPA.	Tetradecanoylphorbol Acetate	71-74	plasminogen	Homo sapiens	23-26
29371085-0	2018	(E)-2-Methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol attenuates PMA-induced inflammatory responses in human monocytic cells through PKCdelta/JNK/AP-1 pathways.	Tetradecanoylphorbol Acetate	71-74	protein kinase C delta	Homo sapiens	139-147
29310423-6	2018	Our results showed that Phloxine O downregulated phorbol 12-myristate 13-acetate-induced production of TSLP in a murine keratinocyte cell line (PAM212).	Tetradecanoylphorbol Acetate	49-80	thymic stromal lymphopoietin	Mus musculus	103-107
29271701-5	2018	Additionally, TPA-induced phosphorylations of extracellular signal-regulated kinases, 90 kDa ribosomal S6 kinase 2, c-Jun N-terminal kinases, and glycogen synthase kinase 3beta were downregulated in the presence of RGO.	Tetradecanoylphorbol Acetate	14-17	glycogen synthase kinase 3 beta	Homo sapiens	116-176
29458014-0	2018	Topical delivery of l-theanine ameliorates TPA-induced acute skin inflammation via downregulating endothelial PECAM-1 and neutrophil infiltration and activation.	Tetradecanoylphorbol Acetate	43-46	platelet/endothelial cell adhesion molecule 1	Mus musculus	110-117
29458014-4	2018	Subsequently l-theanine ameliorated TPA-induced erythema, vascular permeability increase, epidermal and dermal hyperplasia, neutrophil infiltration and activation via downregulating the expression of PECAM-1 (a platelet endothelial adhesion molecule-1) in blood vessels and the production of pro-inflammatory cytokines IL-1beta, TNF-alpha, and mediator cyclooxygenase-2 (COX-2), which is mainly expressed in neutrophils.	Tetradecanoylphorbol Acetate	36-39	platelet/endothelial cell adhesion molecule 1	Mus musculus	200-207
29458014-4	2018	Subsequently l-theanine ameliorated TPA-induced erythema, vascular permeability increase, epidermal and dermal hyperplasia, neutrophil infiltration and activation via downregulating the expression of PECAM-1 (a platelet endothelial adhesion molecule-1) in blood vessels and the production of pro-inflammatory cytokines IL-1beta, TNF-alpha, and mediator cyclooxygenase-2 (COX-2), which is mainly expressed in neutrophils.	Tetradecanoylphorbol Acetate	36-39	prostaglandin-endoperoxide synthase 2	Mus musculus	353-369
30073169-10	2018	In agreement, 80 nM PMA (a PKC activator) mimicked the effect of LPS on the activation of the MEK/ERK/TSC2/mTORC1/S6K pathway, monocyte adhesion to ECV cells and actin cytoskeleton rearrangement.	Tetradecanoylphorbol Acetate	20-23	CREB regulated transcription coactivator 1	Mus musculus	107-113
29842805-4	2018	On the other hand, the dissociation of HDAC1 from the SOD3 promoter region and the enrichment of p300, a histone acetyltransferase (HAT), within that region were observed in TPA-induced THP-1 cells.	Tetradecanoylphorbol Acetate	174-177	E1A binding protein p300	Homo sapiens	97-101
29059167-7	2018	Our data demonstrate for the first time that RhoA is a tumor suppressor in 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol 13-acetate skin carcinogenesis and identify Rho signaling dependent on RhoA and RhoB as a potent driver of tumor progression.	Tetradecanoylphorbol Acetate	106-142	ras homolog family member A	Mus musculus	45-49
29059167-7	2018	Our data demonstrate for the first time that RhoA is a tumor suppressor in 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol 13-acetate skin carcinogenesis and identify Rho signaling dependent on RhoA and RhoB as a potent driver of tumor progression.	Tetradecanoylphorbol Acetate	106-142	ras homolog family member A	Mus musculus	203-207
29059167-7	2018	Our data demonstrate for the first time that RhoA is a tumor suppressor in 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol 13-acetate skin carcinogenesis and identify Rho signaling dependent on RhoA and RhoB as a potent driver of tumor progression.	Tetradecanoylphorbol Acetate	106-142	ras homolog family member B	Mus musculus	212-216
29842805-6	2018	The present results showed that the MEF2A and MEF2D function as mediators for TPA-elicited SOD3 expression by interacting with HDAC or p300.	Tetradecanoylphorbol Acetate	78-81	myocyte enhancer factor 2A	Homo sapiens	36-41
29842805-6	2018	The present results showed that the MEF2A and MEF2D function as mediators for TPA-elicited SOD3 expression by interacting with HDAC or p300.	Tetradecanoylphorbol Acetate	78-81	E1A binding protein p300	Homo sapiens	135-139
29477140-3	2018	We observed that, upon phorbol 12-myristate 13-acetate (PMA) treatment, THP-1 cells differentiated into monocytes by down-regulating Aurora kinase A (AURKA), resulting in a reduction in H3S10 phosphorylation.	Tetradecanoylphorbol Acetate	23-54	aurora kinase A	Homo sapiens	133-148
29146594-5	2018	Here we demonstrate that activation of protein kinase C (PKC) by phorbol myristate acetate, Gq/11-coupled GPCR, or epidermal growth factor receptor stimulation promotes beta-arrestin2 recruitment to unliganded AT1 angiotensin receptor (AT1R).	Tetradecanoylphorbol Acetate	65-90	angiotensin II receptor type 1	Homo sapiens	210-234
29146594-5	2018	Here we demonstrate that activation of protein kinase C (PKC) by phorbol myristate acetate, Gq/11-coupled GPCR, or epidermal growth factor receptor stimulation promotes beta-arrestin2 recruitment to unliganded AT1 angiotensin receptor (AT1R).	Tetradecanoylphorbol Acetate	65-90	angiotensin II receptor type 1	Homo sapiens	236-240
29477140-3	2018	We observed that, upon phorbol 12-myristate 13-acetate (PMA) treatment, THP-1 cells differentiated into monocytes by down-regulating Aurora kinase A (AURKA), resulting in a reduction in H3S10 phosphorylation.	Tetradecanoylphorbol Acetate	23-54	aurora kinase A	Homo sapiens	150-155
29477140-3	2018	We observed that, upon phorbol 12-myristate 13-acetate (PMA) treatment, THP-1 cells differentiated into monocytes by down-regulating Aurora kinase A (AURKA), resulting in a reduction in H3S10 phosphorylation.	Tetradecanoylphorbol Acetate	56-59	aurora kinase A	Homo sapiens	133-148
29477140-3	2018	We observed that, upon phorbol 12-myristate 13-acetate (PMA) treatment, THP-1 cells differentiated into monocytes by down-regulating Aurora kinase A (AURKA), resulting in a reduction in H3S10 phosphorylation.	Tetradecanoylphorbol Acetate	56-59	aurora kinase A	Homo sapiens	150-155
29423390-10	2018	The results showed that TPA-induced skin hyperplasia, epidermal cell proliferation, and cyclooxygenase-2 (COX-2) expression were reduced in HPD group compared to ND group.	Tetradecanoylphorbol Acetate	24-27	prostaglandin-endoperoxide synthase 2	Mus musculus	88-104
29423390-10	2018	The results showed that TPA-induced skin hyperplasia, epidermal cell proliferation, and cyclooxygenase-2 (COX-2) expression were reduced in HPD group compared to ND group.	Tetradecanoylphorbol Acetate	24-27	prostaglandin-endoperoxide synthase 2	Mus musculus	106-111
29723192-6	2018	The induction of TTP following TPA or UVB treatment was attenuated by calcineurin inhibition in keratinocytes, and correspondingly, disruption of calcineurin signaling down-regulated the amounts of TTP in both clinical and H-rasV12-transformed keratinocyte tumor models.	Tetradecanoylphorbol Acetate	31-34	ZFP36 ring finger protein	Homo sapiens	17-20
29723192-6	2018	The induction of TTP following TPA or UVB treatment was attenuated by calcineurin inhibition in keratinocytes, and correspondingly, disruption of calcineurin signaling down-regulated the amounts of TTP in both clinical and H-rasV12-transformed keratinocyte tumor models.	Tetradecanoylphorbol Acetate	31-34	ZFP36 ring finger protein	Homo sapiens	198-201
29115558-7	2018	The results demonstrated that treatment of mice with bryostatin 1 at a 30 microM dose prior to TPA administration significantly (P&lt;0.005) inhibited the TPA-mediated increase in the level of COX-2.	Tetradecanoylphorbol Acetate	155-158	cytochrome c oxidase II, mitochondrial	Mus musculus	193-198
29723216-6	2018	We found that PMA induces the interaction of SLC11A1 with c-Src kinase.	Tetradecanoylphorbol Acetate	14-17	C-terminal Src kinase	Homo sapiens	58-70
29531138-4	2018	In vitro analysis indicated that HMGB1, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-1beta (IL-1beta) were secreted in response to tumor necrosis factor-alpha (TNF-alpha) stimuli in human gingival epithelial cells (HGECs) and human monocytic leukemia cells (THP-1) treated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	308-333	high mobility group box 1	Homo sapiens	33-38
29371085-6	2018	MMPP inhibited PMA-induced membrane translocation of PKCdelta, phosphorylation of JNK, and nuclear translocation of AP-1, resulting in downregulation of cyclooxygenase-2 and chemokine ligand 5 production.	Tetradecanoylphorbol Acetate	15-18	protein kinase C delta	Homo sapiens	53-61
28484266-4	2017	Upon phorbol-myristate acetate or Vitamin D3/granulocyte macrophage colony-stimulating factor (GM-CSF)-driven differentiation, both ADAR1 and ADAR2 enzymes are upregulated, with a concomitant global increase of A-to-I RNA editing.	Tetradecanoylphorbol Acetate	5-30	adenosine deaminase RNA specific B1	Homo sapiens	142-147
29371085-7	2018	These findings indicate that MMPP inhibits inflammatory responses in THP-1 cells by mitigating PMA-induced activation of PKCdelta and JNK and nuclear translocation of AP-1.	Tetradecanoylphorbol Acetate	95-98	protein kinase C delta	Homo sapiens	121-129
26390181-8	2017	Furthermore, Mw strongly suppressed PMA-induced membrane localization of protein kinase C alpha (PKCalpha) since PKCalpha inhibition caused a marked decrease in PMA-induced MMP-9 secretion as well as AKT/ERK-1/2 activation.	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase 3	Mus musculus	204-211
29563383-1	2018	To investigate whether focal adhesion kinase (FAK) can participate in the secretion of matrix metalloproteinase 9 (MMP9) after CD147 stimulation in THP-1 induced macrophages; thus, to explore the potential treatment perspectives for acute coronary syndrome (ACS).Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages.	Tetradecanoylphorbol Acetate	263-294	protein tyrosine kinase 2	Homo sapiens	23-44
26390181-8	2017	Furthermore, Mw strongly suppressed PMA-induced membrane localization of protein kinase C alpha (PKCalpha) since PKCalpha inhibition caused a marked decrease in PMA-induced MMP-9 secretion as well as AKT/ERK-1/2 activation.	Tetradecanoylphorbol Acetate	161-164	matrix metallopeptidase 9	Mus musculus	173-178
29563383-1	2018	To investigate whether focal adhesion kinase (FAK) can participate in the secretion of matrix metalloproteinase 9 (MMP9) after CD147 stimulation in THP-1 induced macrophages; thus, to explore the potential treatment perspectives for acute coronary syndrome (ACS).Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages.	Tetradecanoylphorbol Acetate	263-294	protein tyrosine kinase 2	Homo sapiens	46-49
28966330-3	2017	Activation of PKCalpha and PKCbeta by TPA (12-O-Tetradecanoylphorbol 13-acetate) increased MR proteins and its transcriptional activities in HEK293-MR cells.	Tetradecanoylphorbol Acetate	38-41	protein kinase C, beta	Mus musculus	27-34
28966330-3	2017	Activation of PKCalpha and PKCbeta by TPA (12-O-Tetradecanoylphorbol 13-acetate) increased MR proteins and its transcriptional activities in HEK293-MR cells.	Tetradecanoylphorbol Acetate	43-79	protein kinase C, beta	Mus musculus	27-34
29563383-1	2018	To investigate whether focal adhesion kinase (FAK) can participate in the secretion of matrix metalloproteinase 9 (MMP9) after CD147 stimulation in THP-1 induced macrophages; thus, to explore the potential treatment perspectives for acute coronary syndrome (ACS).Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages.	Tetradecanoylphorbol Acetate	296-299	protein tyrosine kinase 2	Homo sapiens	23-44
29563383-1	2018	To investigate whether focal adhesion kinase (FAK) can participate in the secretion of matrix metalloproteinase 9 (MMP9) after CD147 stimulation in THP-1 induced macrophages; thus, to explore the potential treatment perspectives for acute coronary syndrome (ACS).Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages.	Tetradecanoylphorbol Acetate	296-299	protein tyrosine kinase 2	Homo sapiens	46-49
27942049-8	2016	Moreover, in HEK cells expressing KLHL3 and WNK4, we showed that the activation of protein kinase C by phorbol 12-myristate 13-acetate induces KLHL3S433-P and increases WNK4 levels by abrogating its ubiquitination.	Tetradecanoylphorbol Acetate	103-134	WNK lysine deficient protein kinase 4	Mus musculus	44-48
29269607-6	2018	This compound blocked both Nox organizer 1 (NOXO1)/Nox activator 1 (NOXA1)-dependent and phorbol 12-myristate 13-acetate-stimulated Nox1-mediated ROS production in colon cancer cells.	Tetradecanoylphorbol Acetate	89-120	NADPH oxidase 1	Homo sapiens	132-136
27942049-8	2016	Moreover, in HEK cells expressing KLHL3 and WNK4, we showed that the activation of protein kinase C by phorbol 12-myristate 13-acetate induces KLHL3S433-P and increases WNK4 levels by abrogating its ubiquitination.	Tetradecanoylphorbol Acetate	103-134	WNK lysine deficient protein kinase 4	Mus musculus	169-173
28479361-5	2017	Inhibitory affinity of suramin to OATP2A1 was the highest (IC50,2A1 of 0.17 muM), and its IC50 values to MRP4-mediated PGE2 transport (IC50,MRP4) and PGE2 synthesis in human U-937 cells treated with phorbol 12-myristate 13-acetate (IC50,Syn) were 73.6 and 336.7 times higher than IC50,2A1, respectively.	Tetradecanoylphorbol Acetate	199-230	solute carrier organic anion transporter family member 2A1	Homo sapiens	34-41
28634425-3	2017	Here, we triggered inflammation in HT1080 fibrosarcoma cells with phorbol-12-myristate-13-acetate (PMA), an inducer of COX-2 and of MT1-MMP.	Tetradecanoylphorbol Acetate	66-97	matrix metallopeptidase 14	Homo sapiens	132-139
29207123-7	2018	In conclusion, berberine reduced NLRP3 inflammasone expression by suppressing the activation of the TLR4/Myd88/NF-kappaB signaling pathway in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	142-145	MYD88 innate immune signal transduction adaptor	Homo sapiens	105-110
28634425-3	2017	Here, we triggered inflammation in HT1080 fibrosarcoma cells with phorbol-12-myristate-13-acetate (PMA), an inducer of COX-2 and of MT1-MMP.	Tetradecanoylphorbol Acetate	99-102	matrix metallopeptidase 14	Homo sapiens	132-139
28634425-6	2017	Among the signal-transducing pathways explored, the silencing of MT1-MMP prevented PMA from phosphorylating extracellular signal-regulated kinase, inhibitor of kappaB, and p105 nuclear factor kappaB (NF-kappaB) intermediates.	Tetradecanoylphorbol Acetate	83-86	matrix metallopeptidase 14	Homo sapiens	65-72
27636008-4	2016	METHODS: In vitro toxicity was investigated in human skin melanoma Sk-Mel-28 cells, and skin squamous cell carcinoma was induced in CD1 mice by dimethylbenzanthracene (DMBA) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	178-215	CD1c molecule	Homo sapiens	132-135
30175778-9	2018	RJ and BGPP suppressed phorbol-12-myristate-13-acetate-induced Tyr311 phosphorylation of PKCdelta in HeLa cells.	Tetradecanoylphorbol Acetate	23-54	protein kinase C delta	Homo sapiens	89-97
28123881-0	2016	T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development.	Tetradecanoylphorbol Acetate	59-62	furin (paired basic amino acid cleaving enzyme)	Mus musculus	39-44
27654969-5	2016	Specific inhibitors and mutagenesis studies showed that PKCdelta, JNK1/2, Erk1/2, NF-kappaB, and AP-1 were critical for TPA-induced uPAR expression.	Tetradecanoylphorbol Acetate	120-123	protein kinase C delta	Homo sapiens	56-64
27654969-6	2016	Application of DHA suppressed TPA-induced translocation of PKCdelta, activation of the JNK1/2 and Erk1/2 signaling pathways, and subsequent AP-1 and NF-kappaB transactivation.	Tetradecanoylphorbol Acetate	30-33	protein kinase C delta	Homo sapiens	59-67
28367652-0	2017	Astragaloside IV inhibits PMA-induced EPCR shedding through MAPKs and PKC pathway.	Tetradecanoylphorbol Acetate	26-29	protein C receptor	Homo sapiens	38-42
28277539-3	2017	DMBA/TPA skin carcinogenesis studies in mice have shown that Rac1 is required for chemically induced skin papilloma formation.	Tetradecanoylphorbol Acetate	5-8	Rac family small GTPase 1	Mus musculus	61-65
29057467-6	2018	KEY RESULTS: Vortioxetine significantly reduced the PMA-induced oxidative burst in monocytes and in macrophages (M1 and M2), causing a concomitant shift of macrophages from the M1 to the M2 phenotype, demonstrated by a significant decrease in the expression of the surface marker CD86 and an increase in CD206.	Tetradecanoylphorbol Acetate	52-55	mannose receptor C-type 1	Homo sapiens	304-309
27349720-3	2016	This study aimed to assess the effects of phorbol myristate acetate/ionomycin (PMA/IONO) on the growth and apoptosis of the DLBCL cell line OCI-LY1, and their associations with A20, MALT1 and survivin levels.	Tetradecanoylphorbol Acetate	42-67	MALT1 paracaspase	Homo sapiens	182-187
29178986-0	2018	Thrombolytic fucoidans inhibit the tPA-PAI1 complex, indicating activation of plasma tissue-type plasminogen activator is a mechanism of fucoidan-mediated thrombolysis in a mouse thrombosis model.	Tetradecanoylphorbol Acetate	35-38	plasminogen activator, tissue	Mus musculus	85-118
28097492-9	2017	TRPM2 and TRPV1 currents were increased by the PKC activator, phorbol myristate acetate (PMA), although the currents were decreased by ACA, CPZ, and the PKC inhibitor, bisindolylmaleimide I (BIM).	Tetradecanoylphorbol Acetate	62-87	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	10-15
28097492-9	2017	TRPM2 and TRPV1 currents were increased by the PKC activator, phorbol myristate acetate (PMA), although the currents were decreased by ACA, CPZ, and the PKC inhibitor, bisindolylmaleimide I (BIM).	Tetradecanoylphorbol Acetate	89-92	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	10-15
29296668-5	2017	Prominent among these targets was the mitochondrial carnitine-acylcarnitine translocase SLC25A20, which we show is inhibited in cells by IngMeb and the more stable analogue ingenol disoxate (IngDsx), but not by the canonical PKC agonist 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	237-273	solute carrier family 25 member 20	Homo sapiens	88-96
27452520-6	2017	Application of in vivo stress using the DMBA/TPA skin carcinogenesis protocol revealed that combined inactivation of E2f7/8 enhanced tumorigenesis and accelerated malignant progression.	Tetradecanoylphorbol Acetate	45-48	E2F transcription factor 7	Homo sapiens	117-123
29296668-5	2017	Prominent among these targets was the mitochondrial carnitine-acylcarnitine translocase SLC25A20, which we show is inhibited in cells by IngMeb and the more stable analogue ingenol disoxate (IngDsx), but not by the canonical PKC agonist 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	275-278	solute carrier family 25 member 20	Homo sapiens	88-96
28978712-3	2017	Using highly sensitive tyramide signal amplification, we determined that LANA localizes to the cytoplasm in different cell types undergoing the lytic cycle of replication after de novo primary infection and after spontaneous, tetradecanoyl phorbol acetate-, or open reading frame 50 (ORF50)/replication transactivator (RTA)-induced activation.	Tetradecanoylphorbol Acetate	226-255	LANA	Human gammaherpesvirus 8	73-77
27930810-11	2017	In vitro, preincubation with alamandine dose-dependently abrogated PMA-induced neutrophil degranulation of MMP-9 and MPO.	Tetradecanoylphorbol Acetate	67-70	matrix metallopeptidase 9	Mus musculus	107-112
28804104-0	2017	alpha-Cyperone Inhibits PMA-Induced EPCR Shedding through PKC Pathway.	Tetradecanoylphorbol Acetate	24-27	protein C receptor	Homo sapiens	36-40
27706112-4	2017	METHODS: The expression of TRPV4 in RAW264.7 and phorbol-12-myristate-13-acetate (PMA) induced U937, THP-1 cells was detected by immunofluorescence, and western blot was used to detect the TRPV4 expression before and after PMA induction.	Tetradecanoylphorbol Acetate	49-80	transient receptor potential cation channel subfamily V member 4	Homo sapiens	27-32
27706112-4	2017	METHODS: The expression of TRPV4 in RAW264.7 and phorbol-12-myristate-13-acetate (PMA) induced U937, THP-1 cells was detected by immunofluorescence, and western blot was used to detect the TRPV4 expression before and after PMA induction.	Tetradecanoylphorbol Acetate	82-85	transient receptor potential cation channel subfamily V member 4	Homo sapiens	27-32
27706112-4	2017	METHODS: The expression of TRPV4 in RAW264.7 and phorbol-12-myristate-13-acetate (PMA) induced U937, THP-1 cells was detected by immunofluorescence, and western blot was used to detect the TRPV4 expression before and after PMA induction.	Tetradecanoylphorbol Acetate	82-85	transient receptor potential cation channel subfamily V member 4	Homo sapiens	189-194
28804104-6	2017	To observe the effect, we investigated this issue by detection the effect of alpha-cyperone on phorbol-12-myristate 13-acetate (PMA)-induced EPCR shedding in human umbilical vein endothelial cells (HUVECs).	Tetradecanoylphorbol Acetate	95-126	protein C receptor	Homo sapiens	141-145
28804104-6	2017	To observe the effect, we investigated this issue by detection the effect of alpha-cyperone on phorbol-12-myristate 13-acetate (PMA)-induced EPCR shedding in human umbilical vein endothelial cells (HUVECs).	Tetradecanoylphorbol Acetate	128-131	protein C receptor	Homo sapiens	141-145
28804104-12	2017	Given these results, alpha-cyperone inhibits PMA-induced EPCR shedding through PKC pathway, which will provide an experimental basis for further research on alpha-cyperone.	Tetradecanoylphorbol Acetate	45-48	protein C receptor	Homo sapiens	57-61
28057557-6	2017	The anesthetic-induced depression of ERK1/2 phosphorylation was blocked by 0.1 muM phorbol-12-myristate 13-acetate (an activator of PKC), 50 muM U73122 (an inhibitor of PLC).	Tetradecanoylphorbol Acetate	83-114	mitogen-activated protein kinase 3	Mus musculus	37-43
28842814-11	2017	Activation of PKCgamma by PMA aggravated allodynia and increased the expression of CGRP and c-Fos.	Tetradecanoylphorbol Acetate	26-29	calcitonin-related polypeptide alpha	Rattus norvegicus	83-87
28079139-8	2017	Our findings demonstrate that blood occludin levels correlate well with the extent of BBB damage and thus may serve as a clinically relevant biomarker for evaluating the risk of ICH before tPA administration.	Tetradecanoylphorbol Acetate	189-192	occludin	Homo sapiens	36-44
28926616-4	2017	Here, we report that mTORC1 activation by phorbol 12,13-myristate acetate (PMA) requires both classic, cPKC, and novel PKC (nPKC) isoforms, specifically PKCeta, acting through distinct pathways.	Tetradecanoylphorbol Acetate	75-78	CREB regulated transcription coactivator 1	Mus musculus	21-27
27810601-0	2017	Differential roles of PKC isoforms (PKCs) and Ca2+ in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells.	Tetradecanoylphorbol Acetate	63-94	mitogen-activated protein kinase 14	Mus musculus	116-123
28878626-8	2017	Finally, the expression of a dominant negative version of H-Ras, an upstream activator of ERK1/2, abolishes phorbol 12-myristate 13-acetate (PMA)-mediated down regulation of NET in a manner similar to MKP3.	Tetradecanoylphorbol Acetate	108-139	mitogen activated protein kinase 3	Rattus norvegicus	90-96
27810601-0	2017	Differential roles of PKC isoforms (PKCs) and Ca2+ in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells.	Tetradecanoylphorbol Acetate	96-99	mitogen-activated protein kinase 14	Mus musculus	116-123
27810601-5	2017	Basal, GnRH- and PMA- stimulation of p38MAPK phosphorylation in alphaT3-1 cells is mediated by Ca2+ influx via voltage-gated Ca2+ channels and Ca2+ mobilization, while in the differentiated LbetaT2 gonadotrope cells it is mediated only by Ca2+ mobilization.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase 14	Mus musculus	37-44
28878626-8	2017	Finally, the expression of a dominant negative version of H-Ras, an upstream activator of ERK1/2, abolishes phorbol 12-myristate 13-acetate (PMA)-mediated down regulation of NET in a manner similar to MKP3.	Tetradecanoylphorbol Acetate	141-144	mitogen activated protein kinase 3	Rattus norvegicus	90-96
27780134-4	2016	The four norlignans (1-4) potently inhibited the release of beta-hexosaminidase from immunoglobulin E (IgE)/dinitrophenol-conjugated bovine serum albumin (DNP-BSA)-treated rat basophilic leukemia (RBL)-2H3 and A23187 plus phorbol 12-myristate 13-acetate co-treated isolated rat primary mast cells, as markers of degranulation and histamine release.	Tetradecanoylphorbol Acetate	222-253	O-GlcNAcase	Rattus norvegicus	60-79
28789420-3	2017	In the present study, the effect of KLF5 on phorbol 12-myristate 13-acetate (PMA)-induced apoptosis was investigated in prostate cancer LNCaP cells.	Tetradecanoylphorbol Acetate	44-75	Kruppel like factor 5	Homo sapiens	36-40
28789420-3	2017	In the present study, the effect of KLF5 on phorbol 12-myristate 13-acetate (PMA)-induced apoptosis was investigated in prostate cancer LNCaP cells.	Tetradecanoylphorbol Acetate	77-80	Kruppel like factor 5	Homo sapiens	36-40
27809835-10	2016	Moreover, Anv-polysaccharides strongly inhibited PMA-induced PKCbeta and p47phox translocation to membranes and p47phox phosphorylation on Ser328, a main PKC target.	Tetradecanoylphorbol Acetate	49-52	protein kinase C beta	Homo sapiens	61-68
28789420-6	2017	Knockdown of KLF5 significantly decreased PMA-induced apoptosis, while cell apoptosis was significantly increased following KLF5 overexpression compared with the corresponding control groups.	Tetradecanoylphorbol Acetate	42-45	Kruppel like factor 5	Homo sapiens	13-17
27809835-10	2016	Moreover, Anv-polysaccharides strongly inhibited PMA-induced PKCbeta and p47phox translocation to membranes and p47phox phosphorylation on Ser328, a main PKC target.	Tetradecanoylphorbol Acetate	49-52	protein kinase C beta	Homo sapiens	61-64
28789420-8	2017	Using the control medium from cells treated with PMA, it was demonstrated that KLF5 is required for the control medium to induce apoptosis.	Tetradecanoylphorbol Acetate	49-52	Kruppel like factor 5	Homo sapiens	79-83
28789420-13	2017	Furthermore, KLF5 is essential for activity of the autocrine factor TNFalpha, which is secreted by cells treated with PMA and mediates the function of PMA-induced apoptosis through regulating the activity of JNK signaling pathway.	Tetradecanoylphorbol Acetate	118-121	Kruppel like factor 5	Homo sapiens	13-17
27680589-5	2016	Compound 4 pretreatment resulted in markedly suppression of TPA-induced IL-1beta, IL-6, TNF-alpha, and COX-2, respectively.	Tetradecanoylphorbol Acetate	60-63	cytochrome c oxidase II, mitochondrial	Mus musculus	103-108
28498408-8	2017	However, subsequent re-stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin resulted in enhanced IL-17 production and expression, particularly in CD4+ surface CXCR3 positive cells.	Tetradecanoylphorbol Acetate	40-71	C-X-C motif chemokine receptor 3	Homo sapiens	175-180
27520485-7	2016	At the molecular level, the expression of several key TPA-induced pro-survival and pro-proliferative genes (Bcl2, Cyclin D1, and c-Myc) decreased rapidly after BET inhibition.	Tetradecanoylphorbol Acetate	54-57	cyclin D1	Homo sapiens	114-123
27520485-11	2016	Chromatin immunoprecipitation assays showed that TPA elevated H3K27Ac enrichment in the COX2 promoter region, which is mediated by p300, and Brd4.	Tetradecanoylphorbol Acetate	49-52	E1A binding protein p300	Homo sapiens	131-135
27278128-3	2016	Here we found that a Jurkat subline J.CaM2, initially characterized as LAT deficient, conditionally re-expressed LAT upon the treatment with a protein kinase C activator, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	171-202	calcium/calmodulin dependent protein kinase II beta	Homo sapiens	38-42
27278128-3	2016	Here we found that a Jurkat subline J.CaM2, initially characterized as LAT deficient, conditionally re-expressed LAT upon the treatment with a protein kinase C activator, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	171-202	linker for activation of T cells	Homo sapiens	71-74
27278128-3	2016	Here we found that a Jurkat subline J.CaM2, initially characterized as LAT deficient, conditionally re-expressed LAT upon the treatment with a protein kinase C activator, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	204-207	calcium/calmodulin dependent protein kinase II beta	Homo sapiens	38-42
27278128-3	2016	Here we found that a Jurkat subline J.CaM2, initially characterized as LAT deficient, conditionally re-expressed LAT upon the treatment with a protein kinase C activator, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	204-207	linker for activation of T cells	Homo sapiens	71-74
27278128-7	2016	Mithramycin A, a selective Sp1 DNA-binding inhibitor, abolished LAT expression upon PMA treatment as did calcium ionophore ionomycin (Iono) and valproic acid (VPA), widely used as an anti-epileptic drug.	Tetradecanoylphorbol Acetate	84-87	linker for activation of T cells	Homo sapiens	64-67
28498408-8	2017	However, subsequent re-stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin resulted in enhanced IL-17 production and expression, particularly in CD4+ surface CXCR3 positive cells.	Tetradecanoylphorbol Acetate	73-76	C-X-C motif chemokine receptor 3	Homo sapiens	175-180
28408624-5	2017	Here, by quantifying extracellular DNA or myeloperoxidase, we demonstrate that APC binds human leukocytes and prevents activated platelet supernatant or phorbol 12-myristate 13-acetate (PMA) from inducing NETosis.	Tetradecanoylphorbol Acetate	153-184	APC regulator of WNT signaling pathway	Homo sapiens	79-82
27163855-15	2016	In addition, their anti-metastatic ability was determined through phorbol-12-myristate-13-acetate (PMA)-induced expression of MMP-2 and -9 by Western blotting and gelatin zymography.	Tetradecanoylphorbol Acetate	66-97	matrix metallopeptidase 2	Homo sapiens	126-138
27163855-15	2016	In addition, their anti-metastatic ability was determined through phorbol-12-myristate-13-acetate (PMA)-induced expression of MMP-2 and -9 by Western blotting and gelatin zymography.	Tetradecanoylphorbol Acetate	99-102	matrix metallopeptidase 2	Homo sapiens	126-138
27310149-4	2016	beta-Hexosaminidase release in HMC-1 cells was increased in a concentration-dependent manner, with maximal 6.5- and 8.5-fold increases, by 200 mug/mL 24-epi-7,8-didehydrocimigenol-3-O-xyloside (comp 1) and cimigenol 3-O-beta-d-xyloside (comp 4) compared with those treated with phorbol 12-myristate 13-acetate and A23187 (PMACI), respectively.	Tetradecanoylphorbol Acetate	278-309	O-GlcNAcase	Homo sapiens	0-19
27349859-7	2016	Inhibition of mTORC1 in keratinocytes significantly inhibited their migration in vitro and, in addition, inhibited 12-O-tetradecanoylphorbol-13-acetate-induced proliferation and migration of bulge-region stem cells in vivo.	Tetradecanoylphorbol Acetate	115-151	CREB regulated transcription coactivator 1	Mus musculus	14-20
26912410-4	2016	In the present study we examined PAK2"s role in CCK and TPA-activation of important distal signaling cascades mediating their physiological/pathophysiological effects and analyzed its role in pathophysiological processes important in early pancreatitis.	Tetradecanoylphorbol Acetate	56-59	p21 (RAC1) activated kinase 2	Rattus norvegicus	33-37
28408624-5	2017	Here, by quantifying extracellular DNA or myeloperoxidase, we demonstrate that APC binds human leukocytes and prevents activated platelet supernatant or phorbol 12-myristate 13-acetate (PMA) from inducing NETosis.	Tetradecanoylphorbol Acetate	186-189	APC regulator of WNT signaling pathway	Homo sapiens	79-82
26912410-5	2016	In rat pancreatic acini, PAK2-inhibition by the specific, GP.1.PAK-inhibitor, IPA-3-suppressed cholecystokinin (CCK)/TPA-stimulated activation of focal-adhesion kinases and mitogen-activated protein-kinases.	Tetradecanoylphorbol Acetate	117-120	p21 (RAC1) activated kinase 2	Rattus norvegicus	25-29
26912410-6	2016	PAK2-inhibition reversed the dual stimulatory/inhibitory effect of CCK/TPA on the PI3K/Akt/GSK-3beta pathway.	Tetradecanoylphorbol Acetate	71-74	p21 (RAC1) activated kinase 2	Rattus norvegicus	0-4
28402103-6	2017	We show that C-sep isolated PMNs show higher neutrophil elastase (NE) release following activation by phorbol 12-myristate 13-acetate (PMA) than cells isolated by conventional mucolytic method.	Tetradecanoylphorbol Acetate	102-133	elastase, neutrophil expressed	Homo sapiens	45-64
26912410-6	2016	PAK2-inhibition reversed the dual stimulatory/inhibitory effect of CCK/TPA on the PI3K/Akt/GSK-3beta pathway.	Tetradecanoylphorbol Acetate	71-74	glycogen synthase kinase 3 beta	Rattus norvegicus	91-100
27149996-7	2016	Following stimulation with PMA, human isolated leucocytes, but not mononuclear cells, released enzymatically active PAD, the activity of which was abolished upon pre-incubation of the cells with the glutathione reductase inhibitor 2-AAPA.	Tetradecanoylphorbol Acetate	27-30	glutathione-disulfide reductase	Homo sapiens	199-220
27036017-0	2016	Docosahexaenoic acid inhibits 12-O-tetradecanoylphorbol-13- acetate-induced fascin-1-dependent breast cancer cell migration by suppressing the PKCdelta- and Wnt-1/beta-catenin-mediated pathways.	Tetradecanoylphorbol Acetate	30-67	protein kinase C delta	Homo sapiens	143-162
27353073-8	2016	Topical compd3 penetrates the skin and suppresses phorbol myristate acetate-induced IL-13, IL-22, IL-17F, and IL-23 transcription and calcipotriol-induced thymic stromal lymphopoietin expression in mouse skin.	Tetradecanoylphorbol Acetate	50-75	interleukin 23, alpha subunit p19	Mus musculus	110-115
27156686-3	2016	Also, resveratrol significantly inhibited PMA-induced pro-inflammatory cytokine/chemokine and matrix metalloprotease (MMP-9) production.	Tetradecanoylphorbol Acetate	42-45	matrix metallopeptidase 9	Mus musculus	118-123
27036017-3	2016	TPA dose- and time-dependently increased PKCdelta and STAT3alpha activation and GSK3beta phosphorylation; up-regulated Wnt-1, beta-catenin, and STAT3alpha expression; and increased the nuclear translocation of beta-catenin and STAT3alpha.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	41-49
28402103-6	2017	We show that C-sep isolated PMNs show higher neutrophil elastase (NE) release following activation by phorbol 12-myristate 13-acetate (PMA) than cells isolated by conventional mucolytic method.	Tetradecanoylphorbol Acetate	135-138	elastase, neutrophil expressed	Homo sapiens	45-64
27036017-3	2016	TPA dose- and time-dependently increased PKCdelta and STAT3alpha activation and GSK3beta phosphorylation; up-regulated Wnt-1, beta-catenin, and STAT3alpha expression; and increased the nuclear translocation of beta-catenin and STAT3alpha.	Tetradecanoylphorbol Acetate	0-3	glycogen synthase kinase 3 beta	Homo sapiens	80-88
27036017-9	2016	DHA pretreatment attenuated TPA-induced cell migration, PKCdelta and STAT3alpha activation, GSK3beta phosphorylation, and Wnt-1, beta-catenin, STAT3alpha, and fascin-1 expression.	Tetradecanoylphorbol Acetate	28-31	protein kinase C delta	Homo sapiens	56-64
28656088-11	2017	Phorbol 12-myristate 13-acetate (PMA) treatment increased the cellular expression of AhR.	Tetradecanoylphorbol Acetate	0-31	aryl hydrocarbon receptor	Homo sapiens	85-88
27036017-9	2016	DHA pretreatment attenuated TPA-induced cell migration, PKCdelta and STAT3alpha activation, GSK3beta phosphorylation, and Wnt-1, beta-catenin, STAT3alpha, and fascin-1 expression.	Tetradecanoylphorbol Acetate	28-31	glycogen synthase kinase 3 beta	Homo sapiens	92-100
27036017-10	2016	Our results demonstrated that TPA-induced migration is likely associated with the PKCdelta and Wnt-1 pathways, which lead to STAT3alpha activation, GSK3beta inactivation, and beta-catenin increase and up-regulation of fascin-1 expression.	Tetradecanoylphorbol Acetate	30-33	protein kinase C delta	Homo sapiens	82-90
27036017-10	2016	Our results demonstrated that TPA-induced migration is likely associated with the PKCdelta and Wnt-1 pathways, which lead to STAT3alpha activation, GSK3beta inactivation, and beta-catenin increase and up-regulation of fascin-1 expression.	Tetradecanoylphorbol Acetate	30-33	glycogen synthase kinase 3 beta	Homo sapiens	148-156
27036017-11	2016	Moreover, the anti-metastatic potential of DHA is partly attributed to its suppression of TPA-activated PKCdelta and Wnt-1 signaling.	Tetradecanoylphorbol Acetate	90-93	protein kinase C delta	Homo sapiens	104-112
25753147-6	2016	Additionally, p38delta-null skin and p38delta-null keratinocytes exhibited increased p38alpha activation and signaling in response to acute inflammatory challenges, suggesting a role for p38alpha in stimulating the elevated inflammatory response in p38delta-null skin during the initial phases of the DMBA/TPA treatment compared with similarly treated p38delta(+/+) skin.	Tetradecanoylphorbol Acetate	306-309	mitogen-activated protein kinase 14	Mus musculus	85-93
25753147-6	2016	Additionally, p38delta-null skin and p38delta-null keratinocytes exhibited increased p38alpha activation and signaling in response to acute inflammatory challenges, suggesting a role for p38alpha in stimulating the elevated inflammatory response in p38delta-null skin during the initial phases of the DMBA/TPA treatment compared with similarly treated p38delta(+/+) skin.	Tetradecanoylphorbol Acetate	306-309	mitogen-activated protein kinase 14	Mus musculus	187-195
27179129-7	2016	On the contrary, thrombin dose-dependently prolonged the tPA-PCLT, which was mostly abolished by inhibitors of carboxypeptidase and activated FXIII, suggesting that the prolongation is TAFI- and Factor XIII-dependent.	Tetradecanoylphorbol Acetate	57-60	carboxypeptidase B2	Homo sapiens	185-189
27163640-0	2016	Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells.	Tetradecanoylphorbol Acetate	74-110	free fatty acid receptor 4	Homo sapiens	21-27
28656088-11	2017	Phorbol 12-myristate 13-acetate (PMA) treatment increased the cellular expression of AhR.	Tetradecanoylphorbol Acetate	33-36	aryl hydrocarbon receptor	Homo sapiens	85-88
28186503-4	2017	We found that following 12-O-tetradecanoyl-phorbol-13-acetate (TPA) topical treatment, DLX3 expression is significantly upregulated in the epidermis and keratinocytes from mice overexpressing PKCalpha by transgenic targeting (K5-PKCalpha), resulting in cell cycle block and terminal differentiation.	Tetradecanoylphorbol Acetate	24-61	distal-less homeobox 3	Mus musculus	87-91
28186503-4	2017	We found that following 12-O-tetradecanoyl-phorbol-13-acetate (TPA) topical treatment, DLX3 expression is significantly upregulated in the epidermis and keratinocytes from mice overexpressing PKCalpha by transgenic targeting (K5-PKCalpha), resulting in cell cycle block and terminal differentiation.	Tetradecanoylphorbol Acetate	63-66	distal-less homeobox 3	Mus musculus	87-91
27320605-2	2016	The expression of inhibitory receptors that interact with HLA-G, immunoglobulin-like transcript 2 (ILT2), ILT4, and KIR2DL4 (CD158d) on in vitro-generated macrophages obtained from peripheral blood mononuclear cells and the phorbol 12-myristate 13-acetate (PMA)-activated THP-1 cells were examined by flow cytometry.	Tetradecanoylphorbol Acetate	224-255	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	125-131
27032751-3	2016	Phorbol 12-myristate 13-acetate (PMA), which is a common protein kinase C (PKC) activator, was shown to promote the post-translational processing and nuclear translocation of SREBP-2 in hepatic cells in the current study.	Tetradecanoylphorbol Acetate	0-31	protein kinase C beta	Homo sapiens	75-78
28186503-6	2017	Of particular significance, transcriptional activation of epidermal barrier, antimicrobial peptide and cytokine genes is significantly increased in DLX3cKO skin and further increased by TPA-dependent PKC activation.	Tetradecanoylphorbol Acetate	186-189	distal-less homeobox 3	Mus musculus	148-155
27032751-3	2016	Phorbol 12-myristate 13-acetate (PMA), which is a common protein kinase C (PKC) activator, was shown to promote the post-translational processing and nuclear translocation of SREBP-2 in hepatic cells in the current study.	Tetradecanoylphorbol Acetate	33-36	protein kinase C beta	Homo sapiens	75-78
28322318-0	2017	12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT.	Tetradecanoylphorbol Acetate	0-36	Yes1 associated transcriptional regulator	Homo sapiens	100-103
28322318-0	2017	12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT.	Tetradecanoylphorbol Acetate	38-41	Yes1 associated transcriptional regulator	Homo sapiens	100-103
26923189-4	2016	In whole-cell configuration, the application of phorbol 12-myristate 13-acetate (PMA), a PKC activator, potentiated CaV2.3 currents by ~two-fold.	Tetradecanoylphorbol Acetate	48-79	caveolin 2	Danio rerio	116-120
26923189-4	2016	In whole-cell configuration, the application of phorbol 12-myristate 13-acetate (PMA), a PKC activator, potentiated CaV2.3 currents by ~two-fold.	Tetradecanoylphorbol Acetate	81-84	caveolin 2	Danio rerio	116-120
27216037-7	2016	The interaction is enhanced by the PKC activator TPA and seems to be independent of PKCdelta catalytic activity since the PKC kinase inhibitor GF109203X did not inhibit the interaction.	Tetradecanoylphorbol Acetate	49-52	protein kinase C delta	Homo sapiens	35-38
28322318-2	2017	However, we found that TPA inhibits transformative phenotypes in liver cancer cells via the translocation of YAP from the nucleus, where it functions as a transcriptional co-factor, to the cytoplasm.	Tetradecanoylphorbol Acetate	23-26	Yes1 associated transcriptional regulator	Homo sapiens	109-112
28322318-4	2017	The inhibitory effects of TPA on YAP were AMOT dependent.	Tetradecanoylphorbol Acetate	26-29	Yes1 associated transcriptional regulator	Homo sapiens	33-36
28322318-6	2017	Importantly, the depletion of YAP and AMOT blocked the TPA-reduced transformative phenotypes.	Tetradecanoylphorbol Acetate	55-58	Yes1 associated transcriptional regulator	Homo sapiens	30-33
26797128-7	2016	Expression of a phosphodefective AMPKalpha2 mutant (S491A) prevented the PMA-induced reduction in AMPK activity.	Tetradecanoylphorbol Acetate	73-76	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	33-43
28322318-7	2017	In sum, TPA has been established as an anti-tumorigenic drug in liver cancer cells via YAP and AMOT.	Tetradecanoylphorbol Acetate	8-11	Yes1 associated transcriptional regulator	Homo sapiens	87-90
26797128-7	2016	Expression of a phosphodefective AMPKalpha2 mutant (S491A) prevented the PMA-induced reduction in AMPK activity.	Tetradecanoylphorbol Acetate	73-76	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	33-37
28098862-5	2017	Phorbol 12-myristate 13-acetate (PMA), which is a Rac1 activator, significantly enhanced the expression levels of MMP-2, -3, -9 and -19 proteins, whereas the results of rhein and Rac1 inhibitor NSC23766 were just the opposite.	Tetradecanoylphorbol Acetate	0-31	matrix metallopeptidase 2	Homo sapiens	114-135
26785427-4	2016	On the basis of a tiny chemical modification in TPA-BZP, a green-light donor-acceptor molecule, we designed and synthesized CzP-BZP with this efficeient combination of high PL efficiency of eta(PL) = 75% in the solid state and maximal exciton utilization efficiency up to 48% (especially, the internal quantum efficiency of eta(IQE) = 35% substantially exceed 25% of spin statistics limit) in OLED.	Tetradecanoylphorbol Acetate	48-51	endothelin receptor type A	Homo sapiens	190-193
26950613-8	2016	Furthermore, TGN reduced iNOS and COX-2 expression in a 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation mouse model.	Tetradecanoylphorbol Acetate	56-92	prostaglandin-endoperoxide synthase 2	Mus musculus	34-39
26785427-4	2016	On the basis of a tiny chemical modification in TPA-BZP, a green-light donor-acceptor molecule, we designed and synthesized CzP-BZP with this efficeient combination of high PL efficiency of eta(PL) = 75% in the solid state and maximal exciton utilization efficiency up to 48% (especially, the internal quantum efficiency of eta(IQE) = 35% substantially exceed 25% of spin statistics limit) in OLED.	Tetradecanoylphorbol Acetate	48-51	endothelin receptor type A	Homo sapiens	324-327
27320605-2	2016	The expression of inhibitory receptors that interact with HLA-G, immunoglobulin-like transcript 2 (ILT2), ILT4, and KIR2DL4 (CD158d) on in vitro-generated macrophages obtained from peripheral blood mononuclear cells and the phorbol 12-myristate 13-acetate (PMA)-activated THP-1 cells were examined by flow cytometry.	Tetradecanoylphorbol Acetate	257-260	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	125-131
28098862-5	2017	Phorbol 12-myristate 13-acetate (PMA), which is a Rac1 activator, significantly enhanced the expression levels of MMP-2, -3, -9 and -19 proteins, whereas the results of rhein and Rac1 inhibitor NSC23766 were just the opposite.	Tetradecanoylphorbol Acetate	33-36	matrix metallopeptidase 2	Homo sapiens	114-135
28351321-6	2017	We demonstrate that temsirolimus and torin 1 effectively reduced the constitutive as well as phorbol-myristate-acetate/oncostatin-M-induced expression of mesenchymal markers (fibronectin, vimentin, and YKL40) and neural stem cell markers (Sox2, Oct4, nestin, and mushashi1).	Tetradecanoylphorbol Acetate	93-118	oncostatin M	Homo sapiens	119-131
26531064-3	2016	Here, we show that the receptor-interacting protein kinase (RIPK)-1-stabilizers necrostatin-1 or necrostatin-1s and the mixed lineage kinase domain-like (MLKL)-inhibitor necrosulfonamide prevent monosodium urate (MSU) crystal- or PMA-induced NET formation in human and mouse neutrophils.	Tetradecanoylphorbol Acetate	230-233	mixed lineage kinase domain like pseudokinase	Homo sapiens	120-152
26786889-4	2016	We found that nicotine significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced TSLP expression in BALB/c mice and the mouse keratinocyte cell line PAM212.	Tetradecanoylphorbol Acetate	47-83	thymic stromal lymphopoietin	Mus musculus	98-102
28351321-6	2017	We demonstrate that temsirolimus and torin 1 effectively reduced the constitutive as well as phorbol-myristate-acetate/oncostatin-M-induced expression of mesenchymal markers (fibronectin, vimentin, and YKL40) and neural stem cell markers (Sox2, Oct4, nestin, and mushashi1).	Tetradecanoylphorbol Acetate	93-118	chitinase 3 like 1	Homo sapiens	202-207
26786889-4	2016	We found that nicotine significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced TSLP expression in BALB/c mice and the mouse keratinocyte cell line PAM212.	Tetradecanoylphorbol Acetate	85-88	thymic stromal lymphopoietin	Mus musculus	98-102
26531064-3	2016	Here, we show that the receptor-interacting protein kinase (RIPK)-1-stabilizers necrostatin-1 or necrostatin-1s and the mixed lineage kinase domain-like (MLKL)-inhibitor necrosulfonamide prevent monosodium urate (MSU) crystal- or PMA-induced NET formation in human and mouse neutrophils.	Tetradecanoylphorbol Acetate	230-233	mixed lineage kinase domain like pseudokinase	Homo sapiens	154-158
27939168-11	2017	Consistent with the phospho-ERM level, electric resistance measurements showed that the S331A mutation of TIMAP resulted in faster recovery from the PMA treatment.	Tetradecanoylphorbol Acetate	149-152	protein phosphatase 1 regulatory subunit 16B	Homo sapiens	106-111
26531064-5	2016	Moreover, neutrophils of chronic granulomatous disease patients are shown to lack PMA-induced MLKL phosphorylation.	Tetradecanoylphorbol Acetate	82-85	mixed lineage kinase domain like pseudokinase	Homo sapiens	94-98
27610138-0	2016	tPA-MMP-9 Axis Plays a Pivotal Role in Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and Ischemic Region for Angiogenesis.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Mus musculus	4-9
26399567-6	2016	Nucleolin was identified as one of the proteins in the RNP complex of GCRE-1 with PMA-treated U937 cytosolic extracts by oligo-dT affinity chromatography of poly-adenylated GCRE-1.	Tetradecanoylphorbol Acetate	82-85	nucleolin	Homo sapiens	0-9
28055194-2	2017	This work presents an example of that adding nonredox metal ions as Lewis acid can enhance dioxygen activation by oxidovanadium(IV) complex, [VIV(O)Cl(TPA)]PF6 (where TPA is tris-[(2-pyridy)methyl]amine), which leads to efficient hydrogen abstraction at ambient temperature, whereas, in the absence of a Lewis acid, the catalytic hydrogen abstraction of the oxidovanadium(IV) complex is very sluggish.	Tetradecanoylphorbol Acetate	151-154	sperm associated antigen 17	Homo sapiens	156-159
26874672-6	2016	Suplatast also suppressed ionomycin/phorbol-12-myristate-13-acetate-induced upregulation of IL-2 gene expression in Jurkat cells, in which calcineurin (CN)/nuclear factor of activated T-cells (NFAT) signaling is known to be involved.	Tetradecanoylphorbol Acetate	36-67	nuclear factor of activated T-cells 5	Rattus norvegicus	193-197
27610138-3	2016	In groups 1 and 4, by post-CLI 18 h and day 14, circulating EPC (C-kit+/CD31+, Sca-1+/KDR+) levels were highest in CLI-tPA subgroup.	Tetradecanoylphorbol Acetate	119-122	kinase insert domain protein receptor	Mus musculus	79-90
27610138-8	2016	In conclusion, tPA-MMP-9 axis plays a crucial role in EPC mobilization and angiogenesis in experimental CLI.	Tetradecanoylphorbol Acetate	15-18	matrix metallopeptidase 9	Mus musculus	19-24
26345246-3	2015	It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	143-146	prostaglandin-endoperoxide synthase 2	Mus musculus	245-261
26345246-3	2015	It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	143-146	prostaglandin-endoperoxide synthase 2	Mus musculus	263-268
26580203-6	2015	We also show that in keratinocytes the PMA-stimulated phosphorylation of beta4-T1736 primarily is mediated by PKD2 activation downstream of PKCdelta.	Tetradecanoylphorbol Acetate	39-42	tubulin beta 3 class III	Homo sapiens	73-78
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	73-109	Kruppel like factor 15	Homo sapiens	213-218
26580203-6	2015	We also show that in keratinocytes the PMA-stimulated phosphorylation of beta4-T1736 primarily is mediated by PKD2 activation downstream of PKCdelta.	Tetradecanoylphorbol Acetate	39-42	protein kinase C delta	Homo sapiens	140-148
26217011-7	2015	Tetradecanoyl phorbol acetate (TPA)-induced CD44 cleavage requires dephosphorylation of ICD serine 291, while induced neuregulin release depends on the phosphorylation of several NRG1-ICD serines, in part mediated by protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	0-29	neuregulin 1	Homo sapiens	179-183
26217011-7	2015	Tetradecanoyl phorbol acetate (TPA)-induced CD44 cleavage requires dephosphorylation of ICD serine 291, while induced neuregulin release depends on the phosphorylation of several NRG1-ICD serines, in part mediated by protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	0-29	protein kinase C delta	Homo sapiens	217-238
26217011-7	2015	Tetradecanoyl phorbol acetate (TPA)-induced CD44 cleavage requires dephosphorylation of ICD serine 291, while induced neuregulin release depends on the phosphorylation of several NRG1-ICD serines, in part mediated by protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	0-29	protein kinase C delta	Homo sapiens	240-248
26217011-7	2015	Tetradecanoyl phorbol acetate (TPA)-induced CD44 cleavage requires dephosphorylation of ICD serine 291, while induced neuregulin release depends on the phosphorylation of several NRG1-ICD serines, in part mediated by protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	31-34	neuregulin 1	Homo sapiens	179-183
26217011-7	2015	Tetradecanoyl phorbol acetate (TPA)-induced CD44 cleavage requires dephosphorylation of ICD serine 291, while induced neuregulin release depends on the phosphorylation of several NRG1-ICD serines, in part mediated by protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	31-34	protein kinase C delta	Homo sapiens	217-238
26217011-7	2015	Tetradecanoyl phorbol acetate (TPA)-induced CD44 cleavage requires dephosphorylation of ICD serine 291, while induced neuregulin release depends on the phosphorylation of several NRG1-ICD serines, in part mediated by protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	31-34	protein kinase C delta	Homo sapiens	240-248
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	73-109	retinoid X receptor beta	Homo sapiens	233-240
26391399-6	2015	A pull-down assay revealed that (-)-maackiain disrupted the interaction of Hsp90 with PKCdelta, resulting in the suppression of phorbol 12-myristate 13-acetate (PMA)-induced up-regulation of H1R gene expression in HeLa cells.	Tetradecanoylphorbol Acetate	161-164	protein kinase C delta	Homo sapiens	86-94
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	111-114	Kruppel like factor 15	Homo sapiens	213-218
26391399-10	2015	The underlying mechanism of the suppression of PMA-induced up-regulation of H1R gene expression by (-)-maackiain and Hsp90 inhibitors is the inhibition of PKCdelta activation through the disruption of Hsp90-PKCdelta interaction.	Tetradecanoylphorbol Acetate	47-50	protein kinase C delta	Homo sapiens	155-163
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	Tetradecanoylphorbol Acetate	56-59	cytochrome c oxidase II, mitochondrial	Mus musculus	121-126
26391399-10	2015	The underlying mechanism of the suppression of PMA-induced up-regulation of H1R gene expression by (-)-maackiain and Hsp90 inhibitors is the inhibition of PKCdelta activation through the disruption of Hsp90-PKCdelta interaction.	Tetradecanoylphorbol Acetate	47-50	protein kinase C delta	Homo sapiens	207-215
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase 14	Mus musculus	144-152
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	111-114	retinoid X receptor beta	Homo sapiens	233-240
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	Tetradecanoylphorbol Acetate	56-59	jun proto-oncogene	Mus musculus	154-159
26100520-7	2015	Furthermore, NF-kappaB, Egr-1, and AP-1 DNA binding activities after TPA treatment were dramatically decreased by the combination of ursolic acid + resveratrol.	Tetradecanoylphorbol Acetate	69-72	jun proto-oncogene	Mus musculus	35-39
29098164-8	2017	We found that MISP, KLF10, KLF15, PPP1R18, and RXRbeta proteins could strongly respond to TPA stimulation and activate LCN2 transcriptional expression.	Tetradecanoylphorbol Acetate	90-93	Kruppel like factor 15	Homo sapiens	27-32
29098164-8	2017	We found that MISP, KLF10, KLF15, PPP1R18, and RXRbeta proteins could strongly respond to TPA stimulation and activate LCN2 transcriptional expression.	Tetradecanoylphorbol Acetate	90-93	retinoid X receptor beta	Homo sapiens	47-54
26314448-6	2015	The washed platelets were incubated with PDI inhibitor before stimulation with different stimulin, PMA, dibucaine or collagen, and then GPIbalpha was cleaved and ROS levels were elevated more than that in the controls.	Tetradecanoylphorbol Acetate	99-102	prolyl 4-hydroxylase subunit beta	Homo sapiens	41-44
26183538-7	2015	Simultaneous treatment of zymosan and PMA enhanced the nuclear translocation of NF-kappaB subunits, p50 and p65, mediating the increase of TNF-alpha production.	Tetradecanoylphorbol Acetate	38-41	RELA proto-oncogene, NF-kB subunit	Homo sapiens	108-111
28812431-8	2017	In the HEK293 cell line stably expressing hTRPV1, curcumin (1, 3 microm) inhibited phorbol myristate acetate-induced upregulation of membrane TRPV1.	Tetradecanoylphorbol Acetate	83-108	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-48
26222492-0	2015	"Slow" Voltage-Dependent Inactivation of CaV2.2 Calcium Channels Is Modulated by the PKC Activator Phorbol 12-Myristate 13-Acetate (PMA).	Tetradecanoylphorbol Acetate	99-130	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	41-47
26222492-0	2015	"Slow" Voltage-Dependent Inactivation of CaV2.2 Calcium Channels Is Modulated by the PKC Activator Phorbol 12-Myristate 13-Acetate (PMA).	Tetradecanoylphorbol Acetate	132-135	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	41-47
26220523-7	2015	On the mechanism, the phosphorylation mediated by LK6 and Mnk2a is controlled through ERK signal pathway by phorbolmyristate acetate (PMA) avtivation and PD98059 inhibition.	Tetradecanoylphorbol Acetate	108-132	Lk6 kinase	Drosophila melanogaster	50-53
26220523-7	2015	On the mechanism, the phosphorylation mediated by LK6 and Mnk2a is controlled through ERK signal pathway by phorbolmyristate acetate (PMA) avtivation and PD98059 inhibition.	Tetradecanoylphorbol Acetate	134-137	Lk6 kinase	Drosophila melanogaster	50-53
28812431-8	2017	In the HEK293 cell line stably expressing hTRPV1, curcumin (1, 3 microm) inhibited phorbol myristate acetate-induced upregulation of membrane TRPV1.	Tetradecanoylphorbol Acetate	83-108	transient receptor potential cation channel subfamily V member 1	Homo sapiens	43-48
26176694-7	2015	The levels of cleaved caspase-3, cleaved PARP (the substrate of caspase-3) and caspase-9 (the modulator of the caspase-3), which had increased following IR injury, were significantly inhibited by NSP in both wild type and tPA-/- mice.	Tetradecanoylphorbol Acetate	222-225	caspase 9	Mus musculus	79-88
28119748-5	2017	METHODS: Effects of MF and budesonide (BUD) on the phorbol-12-myristate-13-acetate (PMA)-induction of mucin and TNF-alpha in human airway epithelial cells (NCI-H292) were investigated in the present study.	Tetradecanoylphorbol Acetate	51-82	LOC100508689	Homo sapiens	102-107
25700266-12	2015	Treatments with forskolin, phorbol 12-myristate 13-acetate, or phorbol 12-myristate 13-acetate + forskolin could also stimulate Timp1 messenger RNA expression.	Tetradecanoylphorbol Acetate	27-58	metalloproteinase inhibitor 1	Capra hircus	128-133
25818598-0	2015	Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-kappaB and MAPK activation in macrophages and TPA-induced ear edema in mice.	Tetradecanoylphorbol Acetate	118-121	tyrosine aminotransferase	Mus musculus	0-3
25818598-6	2015	Furthermore, Tat-CBR1 protein inhibited inflammatory responses in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation when applied topically.	Tetradecanoylphorbol Acetate	66-102	tyrosine aminotransferase	Mus musculus	13-16
25700266-12	2015	Treatments with forskolin, phorbol 12-myristate 13-acetate, or phorbol 12-myristate 13-acetate + forskolin could also stimulate Timp1 messenger RNA expression.	Tetradecanoylphorbol Acetate	63-94	metalloproteinase inhibitor 1	Capra hircus	128-133
28119748-5	2017	METHODS: Effects of MF and budesonide (BUD) on the phorbol-12-myristate-13-acetate (PMA)-induction of mucin and TNF-alpha in human airway epithelial cells (NCI-H292) were investigated in the present study.	Tetradecanoylphorbol Acetate	84-87	LOC100508689	Homo sapiens	102-107
25818598-6	2015	Furthermore, Tat-CBR1 protein inhibited inflammatory responses in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation when applied topically.	Tetradecanoylphorbol Acetate	104-107	tyrosine aminotransferase	Mus musculus	13-16
27910925-9	2016	In addition, PMA-induced p21Cip1/WAF1 expression, CD14-positive cell labeling intensity and ERK1/2 phosphorylation were markedly inhibited when protein kinase C-delta (PKCdelta) was knocked down.	Tetradecanoylphorbol Acetate	13-16	CD14 molecule	Homo sapiens	50-54
27910925-9	2016	In addition, PMA-induced p21Cip1/WAF1 expression, CD14-positive cell labeling intensity and ERK1/2 phosphorylation were markedly inhibited when protein kinase C-delta (PKCdelta) was knocked down.	Tetradecanoylphorbol Acetate	13-16	protein kinase C delta	Homo sapiens	168-176
27552115-6	2016	The effect of HGF on extracellular trap cell death (ETosis) that mediates cytolytic degranulation was also investigated; however, immobilized IgG- or phorbol myristate acetate-induced ETosis was only minimally attenuated by HGF.	Tetradecanoylphorbol Acetate	150-175	hepatocyte growth factor	Homo sapiens	224-227
25937317-4	2015	The binding interaction initiates a structural adjustment to the bound Plg that facilitates cleavage by proteases (plasminogen activators tPA and uPA) that activate Plg to the active serine protease plasmin.	Tetradecanoylphorbol Acetate	138-141	plasminogen	Homo sapiens	71-74
25937317-4	2015	The binding interaction initiates a structural adjustment to the bound Plg that facilitates cleavage by proteases (plasminogen activators tPA and uPA) that activate Plg to the active serine protease plasmin.	Tetradecanoylphorbol Acetate	138-141	plasminogen	Homo sapiens	165-168
25937317-4	2015	The binding interaction initiates a structural adjustment to the bound Plg that facilitates cleavage by proteases (plasminogen activators tPA and uPA) that activate Plg to the active serine protease plasmin.	Tetradecanoylphorbol Acetate	138-141	plasminogen	Homo sapiens	115-122
26021873-9	2015	The conditioned medium (CM) from HepG2 cells that overexpressed miR-26a reduced the migration ability of THP-1 cells stimulated by phorbol myristate acetate (PMA) increased expression of interleukin (IL)-12b or IL-23 mRNA and decreased expression of chemokine (C-C motif) ligand (CCL)22, CCL17, and IL-10 mRNA, in comparison to the medium from the parental HepG2 cells.	Tetradecanoylphorbol Acetate	131-156	microRNA 26a-1	Homo sapiens	64-71
25689620-7	2015	When the SF were stimulated with phorbol 12-myristate 13-acetate, a protein kinase C activator that bypasses the membranal receptors, galectin-3 knockdown no longer influenced IL-6 secretion.	Tetradecanoylphorbol Acetate	33-64	galectin 3	Homo sapiens	134-144
27676154-0	2016	Phorbol-12-myristate-13-acetate (PMA) mediated transcriptional regulation of Oncostatin-M.	Tetradecanoylphorbol Acetate	0-31	oncostatin M	Homo sapiens	77-89
25463304-3	2015	In the present study, we demonstrated that the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), down-regulated the expression of the AKR1B10 gene in the human lung cancer cell line, A549.	Tetradecanoylphorbol Acetate	62-99	aldo-keto reductase family 1 member B10	Homo sapiens	144-151
25463304-3	2015	In the present study, we demonstrated that the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), down-regulated the expression of the AKR1B10 gene in the human lung cancer cell line, A549.	Tetradecanoylphorbol Acetate	101-104	aldo-keto reductase family 1 member B10	Homo sapiens	144-151
25463304-4	2015	The treatment of A549 cells with TPA for 24h significantly reduced the mRNA levels, protein levels, and promoter activity of AKR1B10 as well as the growth of A549 cells.	Tetradecanoylphorbol Acetate	33-36	aldo-keto reductase family 1 member B10	Homo sapiens	125-132
25615590-9	2015	At a cellular level, FSAP increased cell survival and decreased apoptosis in primary cortical neurons and astrocytes exposed to tPA/NMDA excitotoxicity or oxygen glucose deprivation (OGD)/reoxygenation, respectively.	Tetradecanoylphorbol Acetate	128-131	hyaluronic acid binding protein 2	Mus musculus	21-25
27676154-0	2016	Phorbol-12-myristate-13-acetate (PMA) mediated transcriptional regulation of Oncostatin-M.	Tetradecanoylphorbol Acetate	33-36	oncostatin M	Homo sapiens	77-89
25463304-5	2015	TPA induced the phosphorylation of the MAP kinase, ERK, and U0126, an inhibitor of the MAP kinase kinase, MEK1, blocked the down-regulation of AKR1B10 by TPA, indicating that the MAP kinase ERK plays a role in regulating the expression of AKR1B10.	Tetradecanoylphorbol Acetate	0-3	aldo-keto reductase family 1 member B10	Homo sapiens	143-150
25463304-5	2015	TPA induced the phosphorylation of the MAP kinase, ERK, and U0126, an inhibitor of the MAP kinase kinase, MEK1, blocked the down-regulation of AKR1B10 by TPA, indicating that the MAP kinase ERK plays a role in regulating the expression of AKR1B10.	Tetradecanoylphorbol Acetate	0-3	aldo-keto reductase family 1 member B10	Homo sapiens	239-246
25463304-5	2015	TPA induced the phosphorylation of the MAP kinase, ERK, and U0126, an inhibitor of the MAP kinase kinase, MEK1, blocked the down-regulation of AKR1B10 by TPA, indicating that the MAP kinase ERK plays a role in regulating the expression of AKR1B10.	Tetradecanoylphorbol Acetate	154-157	aldo-keto reductase family 1 member B10	Homo sapiens	143-150
25463304-5	2015	TPA induced the phosphorylation of the MAP kinase, ERK, and U0126, an inhibitor of the MAP kinase kinase, MEK1, blocked the down-regulation of AKR1B10 by TPA, indicating that the MAP kinase ERK plays a role in regulating the expression of AKR1B10.	Tetradecanoylphorbol Acetate	154-157	aldo-keto reductase family 1 member B10	Homo sapiens	239-246
25463304-8	2015	These results suggested that the ERK/c-Jun signaling pathway may play an important role in the TPA-triggered down-regulation of AKR1B10 gene expression.	Tetradecanoylphorbol Acetate	95-98	aldo-keto reductase family 1 member B10	Homo sapiens	128-135
25668240-5	2015	In addition, enhanced Yap1 nuclear localization was also evident in 7,12-dimethylbenzanthracene/12-O-tetradecanoyl-phorbol-13-acetate-induced tumors from Er/+ skin.	Tetradecanoylphorbol Acetate	96-133	yes-associated protein 1	Mus musculus	22-26
26079427-4	2015	p38gamma/delta deletion reduced TPA-induced epidermal hyperproliferation and inflammation; it inhibited expression of proinflammatory cytokines and chemokines in keratinocytes in vitro and in whole skin in vivo, resulting in decreased neutrophil recruitment to skin.	Tetradecanoylphorbol Acetate	32-35	mitogen-activated protein kinase 12	Homo sapiens	0-8
24249517-2	2015	With a tumor promotion model, the JB6 Cl41.5a cell line, we have shown that suppressing 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced OPN expression markedly inhibits TPA-induced colony formation in soft agar, an assay indicative of tumorigenic transformation.	Tetradecanoylphorbol Acetate	88-124	secreted phosphoprotein 1	Mus musculus	139-142
24249517-2	2015	With a tumor promotion model, the JB6 Cl41.5a cell line, we have shown that suppressing 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced OPN expression markedly inhibits TPA-induced colony formation in soft agar, an assay indicative of tumorigenic transformation.	Tetradecanoylphorbol Acetate	126-129	secreted phosphoprotein 1	Mus musculus	139-142
24249517-2	2015	With a tumor promotion model, the JB6 Cl41.5a cell line, we have shown that suppressing 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced OPN expression markedly inhibits TPA-induced colony formation in soft agar, an assay indicative of tumorigenic transformation.	Tetradecanoylphorbol Acetate	172-175	secreted phosphoprotein 1	Mus musculus	139-142
25744030-5	2015	Furthermore, megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of PDGFRbeta and NRP-1 protein expression, complex formation between PDGFRs and NRP-1, PDGFRalphabeta heterodimer complexes, and an increase in PDGF-BB-binding activity.	Tetradecanoylphorbol Acetate	80-105	neuropilin 1	Homo sapiens	171-176
25744030-5	2015	Furthermore, megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of PDGFRbeta and NRP-1 protein expression, complex formation between PDGFRs and NRP-1, PDGFRalphabeta heterodimer complexes, and an increase in PDGF-BB-binding activity.	Tetradecanoylphorbol Acetate	80-105	neuropilin 1	Homo sapiens	234-239
25463482-6	2015	Treatment with phorbol 12-myristate 13-acetate, a commonly used inducer of megakaryopoiesis, reciprocally regulates the expressions of LPA2 and LPA3.	Tetradecanoylphorbol Acetate	15-46	lysophosphatidic acid receptor 3	Homo sapiens	144-148
25973018-12	2015	BCG induced HMGB1, IL-6, IL-10 and TNF-alpha production effectively in PMA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	71-74	high mobility group box 1	Homo sapiens	12-17
25079913-3	2015	CCK (0.3, 100 nM) and TPA (1 muM) activated SFK and altered the activation of FAK proteins (PYK2, p125(FAK)), adaptor proteins (p130(CAS), paxillin), MAPK (p42/44, JNK, p38), Shc, PKC (PKD, MARCKS), Akt but not GSK3-beta.	Tetradecanoylphorbol Acetate	22-25	paxillin	Rattus norvegicus	139-147
25079913-3	2015	CCK (0.3, 100 nM) and TPA (1 muM) activated SFK and altered the activation of FAK proteins (PYK2, p125(FAK)), adaptor proteins (p130(CAS), paxillin), MAPK (p42/44, JNK, p38), Shc, PKC (PKD, MARCKS), Akt but not GSK3-beta.	Tetradecanoylphorbol Acetate	22-25	mitogen activated protein kinase 14	Rattus norvegicus	169-172
25079913-3	2015	CCK (0.3, 100 nM) and TPA (1 muM) activated SFK and altered the activation of FAK proteins (PYK2, p125(FAK)), adaptor proteins (p130(CAS), paxillin), MAPK (p42/44, JNK, p38), Shc, PKC (PKD, MARCKS), Akt but not GSK3-beta.	Tetradecanoylphorbol Acetate	22-25	glycogen synthase kinase 3 beta	Rattus norvegicus	211-220
25370943-5	2015	In vitro, B7-H3 expression was upregulated at both the mRNA and protein levels in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 cells cocultured with HepG2 cells in a Transwell system.	Tetradecanoylphorbol Acetate	82-113	CD276 molecule	Homo sapiens	10-15
25370943-5	2015	In vitro, B7-H3 expression was upregulated at both the mRNA and protein levels in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 cells cocultured with HepG2 cells in a Transwell system.	Tetradecanoylphorbol Acetate	115-118	CD276 molecule	Homo sapiens	10-15
25374129-7	2014	RESULTS: Pretreatment with piceatannol attenuated TPA-induced expression of COX-2 and inducible nitric oxide synthase (iNOS) in mouse skin.	Tetradecanoylphorbol Acetate	50-53	prostaglandin-endoperoxide synthase 2	Mus musculus	76-81
25374129-10	2014	In addition, piceatannol decreased TPA-induced expression of c-Fos and the DNA binding of AP-1.	Tetradecanoylphorbol Acetate	35-38	jun proto-oncogene	Mus musculus	90-94
25374129-11	2014	CONCLUSION: Piceatannol inhibits TPA-induced COX-2 and iNOS expression by blocking the activation of NF-kappaB and AP-1 via suppression of the IKKbeta activity and phosphorylation of MAP kinases, which provides a mechanistic basis of its anti-inflammatory effects in mouse skin.	Tetradecanoylphorbol Acetate	33-36	prostaglandin-endoperoxide synthase 2	Mus musculus	45-50
25374129-11	2014	CONCLUSION: Piceatannol inhibits TPA-induced COX-2 and iNOS expression by blocking the activation of NF-kappaB and AP-1 via suppression of the IKKbeta activity and phosphorylation of MAP kinases, which provides a mechanistic basis of its anti-inflammatory effects in mouse skin.	Tetradecanoylphorbol Acetate	33-36	jun proto-oncogene	Mus musculus	115-119
25479224-9	2014	In the nasal epithelial cells of patients with allergic rhinitis, EGCG significantly decreased phorbol 12-myristate 13-acetate (PMA)-induced MUC5B and MMP-9 expression.	Tetradecanoylphorbol Acetate	95-126	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	141-146
25479224-9	2014	In the nasal epithelial cells of patients with allergic rhinitis, EGCG significantly decreased phorbol 12-myristate 13-acetate (PMA)-induced MUC5B and MMP-9 expression.	Tetradecanoylphorbol Acetate	128-131	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	141-146
25045136-7	2014	The revealed defect-mediated TS-TPA process can boost efficiency of harvesting solar energy in GaNP NWs, beneficial for applications of this novel material system in third-generation photovoltaic devices.	Tetradecanoylphorbol Acetate	32-35	minichromosome maintenance complex component 3 associated protein	Homo sapiens	95-99
25063587-1	2014	UNLABELLED: Pharmacologic and global gene deletion studies demonstrate that cyclooxygenase-2 (PTGS2/COX-2) plays a critical role in DMBA/TPA-induced skin tumor induction.	Tetradecanoylphorbol Acetate	137-140	prostaglandin-endoperoxide synthase 2	Mus musculus	76-92
25063587-1	2014	UNLABELLED: Pharmacologic and global gene deletion studies demonstrate that cyclooxygenase-2 (PTGS2/COX-2) plays a critical role in DMBA/TPA-induced skin tumor induction.	Tetradecanoylphorbol Acetate	137-140	prostaglandin-endoperoxide synthase 2	Mus musculus	94-99
25063587-1	2014	UNLABELLED: Pharmacologic and global gene deletion studies demonstrate that cyclooxygenase-2 (PTGS2/COX-2) plays a critical role in DMBA/TPA-induced skin tumor induction.	Tetradecanoylphorbol Acetate	137-140	cytochrome c oxidase II, mitochondrial	Mus musculus	100-105
25063587-3	2014	Here, cell type-specific Cox-2 gene deletion reveals a vital role for skin epithelial cell COX-2 expression in DMBA/TPA tumor induction.	Tetradecanoylphorbol Acetate	116-119	cytochrome c oxidase II, mitochondrial	Mus musculus	25-30
25063587-3	2014	Here, cell type-specific Cox-2 gene deletion reveals a vital role for skin epithelial cell COX-2 expression in DMBA/TPA tumor induction.	Tetradecanoylphorbol Acetate	116-119	cytochrome c oxidase II, mitochondrial	Mus musculus	91-96
25063587-7	2014	Lipidomics analysis of skin and tumors from DMBA/TPA-treated mice suggests that the prostaglandins PGE2 and PGF2alpha are likely candidates for the epithelial cell COX-2-dependent eicosanoids that mediate tumor progression.	Tetradecanoylphorbol Acetate	49-52	cytochrome c oxidase II, mitochondrial	Mus musculus	164-169
25225290-10	2014	PMA-induced Erk phosphorylation was reduced by ErbB2 inhibitor lapatinib, as well as by knockdown of PKC-delta but not that of PKC-alpha.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	101-110
25260594-8	2014	Further investigation disclosed that the AP-1 activator TPA-induced MMP9 activity and the TPA-promoted migration and invasion of hepatoma cells were significantly attenuated by miR-101 but were enhanced by miR-101 inhibitor.	Tetradecanoylphorbol Acetate	90-93	microRNA 101a	Mus musculus	206-213
25174977-5	2014	Colostral T-cells (n=13) responded to stimulation with PMA/ionomycin with a significantly higher magnitude of IL-17 (p=0.037) and similar IFN-gamma concentrations (p=0.305), while IL-4 (p=0.0002) and IL-10 (p=0.0002) production was decreased compared to PBMC.	Tetradecanoylphorbol Acetate	55-58	interleukin 17A	Equus caballus	110-115
25174977-5	2014	Colostral T-cells (n=13) responded to stimulation with PMA/ionomycin with a significantly higher magnitude of IL-17 (p=0.037) and similar IFN-gamma concentrations (p=0.305), while IL-4 (p=0.0002) and IL-10 (p=0.0002) production was decreased compared to PBMC.	Tetradecanoylphorbol Acetate	55-58	interferon gamma	Equus caballus	138-147
25174977-5	2014	Colostral T-cells (n=13) responded to stimulation with PMA/ionomycin with a significantly higher magnitude of IL-17 (p=0.037) and similar IFN-gamma concentrations (p=0.305), while IL-4 (p=0.0002) and IL-10 (p=0.0002) production was decreased compared to PBMC.	Tetradecanoylphorbol Acetate	55-58	interleukin 10	Equus caballus	200-205
25137020-14	2014	Only metastatic PC3 cells specifically upregulated Etn release in response to TPA treatment.	Tetradecanoylphorbol Acetate	78-81	keratin 6A	Homo sapiens	16-19
25137020-18	2014	CONCLUSIONS: Only the metastatic basal PC3 cell line specifically increased the release of Etn on TPA treatment most probably by PKC activation of PLD1 and increased turnover of EtnPGs.	Tetradecanoylphorbol Acetate	98-101	keratin 6A	Homo sapiens	39-42
25317077-10	2014	MMP-2 activation induced by TPA or Concanavalin A (Con A) was not inhibited by beta1 integrin siRNA knockdown.	Tetradecanoylphorbol Acetate	28-31	matrix metallopeptidase 2	Homo sapiens	0-5
24909729-4	2014	In A549 cells, phorbol 12-myristate 13-acetate (PMA) treatment induced upregulation of COX-2 and MRP4 together, but not other MRP transporters.	Tetradecanoylphorbol Acetate	15-46	prostaglandin-endoperoxide synthase 2	Mus musculus	87-92
24909729-4	2014	In A549 cells, phorbol 12-myristate 13-acetate (PMA) treatment induced upregulation of COX-2 and MRP4 together, but not other MRP transporters.	Tetradecanoylphorbol Acetate	15-46	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	97-101
24909729-4	2014	In A549 cells, phorbol 12-myristate 13-acetate (PMA) treatment induced upregulation of COX-2 and MRP4 together, but not other MRP transporters.	Tetradecanoylphorbol Acetate	48-51	prostaglandin-endoperoxide synthase 2	Mus musculus	87-92
24909729-4	2014	In A549 cells, phorbol 12-myristate 13-acetate (PMA) treatment induced upregulation of COX-2 and MRP4 together, but not other MRP transporters.	Tetradecanoylphorbol Acetate	48-51	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	97-101
24909729-7	2014	Additionally, PMA-treatment increased extracellular PGE2 levels, likely due to increased MRP4 function.	Tetradecanoylphorbol Acetate	14-17	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	89-93
25172501-9	2014	MIF specifically triggered the chemotaxis of NKT cells via CD74 and CXCR2, and the resulting depletion of NKT cells abolished TPA-induced skin inflammation.	Tetradecanoylphorbol Acetate	126-129	macrophage migration inhibitory factor	Homo sapiens	0-3
25172501-10	2014	In TPA-induced skin inflammation, MIF is released from damaged keratinocytes and then triggers the chemotaxis of CD74(+)CXCR2(+) NKT cells for IFN-gamma production.	Tetradecanoylphorbol Acetate	3-6	macrophage migration inhibitory factor	Homo sapiens	34-37
25172501-10	2014	In TPA-induced skin inflammation, MIF is released from damaged keratinocytes and then triggers the chemotaxis of CD74(+)CXCR2(+) NKT cells for IFN-gamma production.	Tetradecanoylphorbol Acetate	3-6	CD74 molecule	Homo sapiens	113-117
25172501-10	2014	In TPA-induced skin inflammation, MIF is released from damaged keratinocytes and then triggers the chemotaxis of CD74(+)CXCR2(+) NKT cells for IFN-gamma production.	Tetradecanoylphorbol Acetate	3-6	C-X-C motif chemokine receptor 2	Homo sapiens	120-125
24742714-10	2014	The above findings, taken together, suggest that genistein inhibits TPA-induced COX-2 expression in MCF10A cells by blocking ERK-mediated phosphorylation of p65 and its subsequent interaction with CBP and TBP.	Tetradecanoylphorbol Acetate	68-71	RELA proto-oncogene, NF-kB subunit	Homo sapiens	157-160
25241044-8	2014	Furthermore, curcumin reversed PMA stimulated PKC activation and suppressed the chronic activation of AMPK, which in turn reduced the expression of MMP-9, MMP-13 and EMMPRIN.	Tetradecanoylphorbol Acetate	31-34	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	102-106
25003971-6	2014	PMA (10(-8) M), a PKC activator, increased Cu(I)-ATPase activity by 60%, whereas calphostin C and U73122 (PKC and PLC inhibitors, respectively) decreased the activity by 40%.	Tetradecanoylphorbol Acetate	0-3	dynein axonemal heavy chain 8	Homo sapiens	43-55
25095870-4	2014	METHODS AND RESULTS: Because Gal-3 is involved in monocyte-to-macrophage transition, we used fresh isolated monocytes and the in vitro model of macrophage differentiation of THP-1 cells stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	202-227	galectin 3	Homo sapiens	29-34
25095870-4	2014	METHODS AND RESULTS: Because Gal-3 is involved in monocyte-to-macrophage transition, we used fresh isolated monocytes and the in vitro model of macrophage differentiation of THP-1 cells stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	229-232	galectin 3	Homo sapiens	29-34
24780839-8	2014	In conclusion, PMA exerted its anti-cancer effects via the activation of pro-apoptotic JNK/p53 and inhibition of pro-proliferative E2F1/AR in prostate cancer cells including CRPC cells.	Tetradecanoylphorbol Acetate	15-18	E2F transcription factor 1 L homeolog	Xenopus laevis	131-135
25013928-5	2014	Mice with epidermal deletion of Meis1 developed significantly fewer DMBA/TPA-induced benign and malignant tumors compared with wild-type mice, suggesting that Meis1 plays a role in both tumor development and malignant progression.	Tetradecanoylphorbol Acetate	73-76	Meis homeobox 1	Mus musculus	32-37
25013928-5	2014	Mice with epidermal deletion of Meis1 developed significantly fewer DMBA/TPA-induced benign and malignant tumors compared with wild-type mice, suggesting that Meis1 plays a role in both tumor development and malignant progression.	Tetradecanoylphorbol Acetate	73-76	Meis homeobox 1	Mus musculus	159-164
24861944-3	2014	In this study, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, induced mitochondrial hyperpolarization and reactive oxygen species generation and also increased mitochondrial translocation of APE1/Ref-1.	Tetradecanoylphorbol Acetate	15-46	apurinic/apyrimidinic endonuclease 1	Mus musculus	222-227
24861944-3	2014	In this study, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, induced mitochondrial hyperpolarization and reactive oxygen species generation and also increased mitochondrial translocation of APE1/Ref-1.	Tetradecanoylphorbol Acetate	48-51	apurinic/apyrimidinic endonuclease 1	Mus musculus	222-227
24571310-4	2014	In vitro gene transfection studies showed that BMI1 inhibited cell myeloid and erythroid differentiation induced by 12-O-tetradecanoyl phorbol-13-acetate (TPA) and histone deacetylase inhibitor sodium butyrate respectively.	Tetradecanoylphorbol Acetate	116-153	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	47-51
24571310-4	2014	In vitro gene transfection studies showed that BMI1 inhibited cell myeloid and erythroid differentiation induced by 12-O-tetradecanoyl phorbol-13-acetate (TPA) and histone deacetylase inhibitor sodium butyrate respectively.	Tetradecanoylphorbol Acetate	155-158	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	47-51
24659803-5	2014	We then investigated tescalcin and CSN activity in human erythroleukemia HEL and promyelocytic leukemia K562 cells and find that phorbol 12-myristate 13-acetate (PMA)-induced differentiation, resulting in the upregulation of tescalcin, coincides with reduced deneddylation of cullin-1 (Cul1) and stabilization of p27(Kip1) - molecular events that are associated with CSN activity.	Tetradecanoylphorbol Acetate	129-160	cullin 1	Homo sapiens	276-284
24659803-5	2014	We then investigated tescalcin and CSN activity in human erythroleukemia HEL and promyelocytic leukemia K562 cells and find that phorbol 12-myristate 13-acetate (PMA)-induced differentiation, resulting in the upregulation of tescalcin, coincides with reduced deneddylation of cullin-1 (Cul1) and stabilization of p27(Kip1) - molecular events that are associated with CSN activity.	Tetradecanoylphorbol Acetate	129-160	cullin 1	Homo sapiens	286-290
24659803-5	2014	We then investigated tescalcin and CSN activity in human erythroleukemia HEL and promyelocytic leukemia K562 cells and find that phorbol 12-myristate 13-acetate (PMA)-induced differentiation, resulting in the upregulation of tescalcin, coincides with reduced deneddylation of cullin-1 (Cul1) and stabilization of p27(Kip1) - molecular events that are associated with CSN activity.	Tetradecanoylphorbol Acetate	162-165	cullin 1	Homo sapiens	276-284
24659803-5	2014	We then investigated tescalcin and CSN activity in human erythroleukemia HEL and promyelocytic leukemia K562 cells and find that phorbol 12-myristate 13-acetate (PMA)-induced differentiation, resulting in the upregulation of tescalcin, coincides with reduced deneddylation of cullin-1 (Cul1) and stabilization of p27(Kip1) - molecular events that are associated with CSN activity.	Tetradecanoylphorbol Acetate	162-165	cullin 1	Homo sapiens	286-290
24334270-8	2014	TPA also inhibited the TGF-beta1-induced apoptosis of Huh7 cells, stimulating the degradation of the PDCD4-protein.	Tetradecanoylphorbol Acetate	0-3	programmed cell death 4	Homo sapiens	101-106
25682767-2	2015	It was suggested that the interleukin-23 (IL-23)/IL-17A cytokine axis played a critical role in the pathogenesis of 12-O-tetradecanoyl phorbol 12-myristate 13-acetate (TPA)-induced K14-VEGF transgenic psoriasis-like mice model.	Tetradecanoylphorbol Acetate	168-171	interleukin 23, alpha subunit p19	Mus musculus	26-40
25682767-2	2015	It was suggested that the interleukin-23 (IL-23)/IL-17A cytokine axis played a critical role in the pathogenesis of 12-O-tetradecanoyl phorbol 12-myristate 13-acetate (TPA)-induced K14-VEGF transgenic psoriasis-like mice model.	Tetradecanoylphorbol Acetate	168-171	interleukin 23, alpha subunit p19	Mus musculus	42-47
25804527-4	2015	TPA increased skin cholesterol levels by inducing de novo synthesis and up-take only in Tm7sf2(+/+) mouse, confirming that the gene maintains cholesterol homeostasis under stress conditions.	Tetradecanoylphorbol Acetate	0-3	transmembrane 7 superfamily member 2	Mus musculus	88-94
25804527-5	2015	Cholesterol sulfate, one of the major players in skin permeability, was doubled by TPA treatment in the skin of wild-type animals but this response was lost in Tm7sf2(-/-) mice.	Tetradecanoylphorbol Acetate	83-86	transmembrane 7 superfamily member 2	Mus musculus	160-166
25501546-5	2015	Short-term treatment with TPA, which is known to activate PKC, was inhibited by VIP pretreatment, while PKC degradation via long-term treatment with TPA mimicked the protective actions of VIP.	Tetradecanoylphorbol Acetate	26-29	protein kinase C, epsilon	Mus musculus	58-61
25501546-5	2015	Short-term treatment with TPA, which is known to activate PKC, was inhibited by VIP pretreatment, while PKC degradation via long-term treatment with TPA mimicked the protective actions of VIP.	Tetradecanoylphorbol Acetate	149-152	protein kinase C, epsilon	Mus musculus	104-107
25453494-6	2015	Moreover, kaempferol repressed phorbol-12-myristate-13-acetate (PMA)-induced MMP-9 expression and activity through suppressing the translocation of protein kinase Cdelta (PKCdelta) and MAPK signaling pathway.	Tetradecanoylphorbol Acetate	31-62	protein kinase C delta	Homo sapiens	148-180
25453494-6	2015	Moreover, kaempferol repressed phorbol-12-myristate-13-acetate (PMA)-induced MMP-9 expression and activity through suppressing the translocation of protein kinase Cdelta (PKCdelta) and MAPK signaling pathway.	Tetradecanoylphorbol Acetate	64-67	protein kinase C delta	Homo sapiens	148-180
25380627-0	2015	Role of GPR120 in cell motile activity induced by 12-O-tetradecanoylphorbol-13-acetate in liver epithelial WB-F344 cells.	Tetradecanoylphorbol Acetate	50-86	free fatty acid receptor 4	Rattus norvegicus	8-14
25380627-3	2015	In this study, we assessed the role of GPR120 in the cell motile activity induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat liver epithelial WB-F344 cells.	Tetradecanoylphorbol Acetate	85-121	free fatty acid receptor 4	Rattus norvegicus	39-45
25380627-3	2015	In this study, we assessed the role of GPR120 in the cell motile activity induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat liver epithelial WB-F344 cells.	Tetradecanoylphorbol Acetate	123-126	free fatty acid receptor 4	Rattus norvegicus	39-45
25380627-4	2015	Cells were treated with TPA at a concentration of 5 nM for 72 h. The expression level of the Gpr120 gene was measured by quantitative real-time RT-PCR analysis.	Tetradecanoylphorbol Acetate	24-27	free fatty acid receptor 4	Rattus norvegicus	93-99
25380627-5	2015	Cells treated with TPA showed the elevated Gpr120 expression, in comparison with untreated cells.	Tetradecanoylphorbol Acetate	19-22	free fatty acid receptor 4	Rattus norvegicus	43-49
25380627-8	2015	The cell motile activity induced by TPA was significantly suppressed by GPR120 knockdown.	Tetradecanoylphorbol Acetate	36-39	free fatty acid receptor 4	Rattus norvegicus	72-78
25380627-9	2015	These results suggest that GPR120 plays an important role in the cell motile activity induced by TPA in WB-F344 cells.	Tetradecanoylphorbol Acetate	97-100	free fatty acid receptor 4	Rattus norvegicus	27-33
25330109-6	2015	An additional H3-derived bait containing the nonhydrolyzable phospho-serine mimic phosphonomethylen-alanine (Pma) at S10 recruited several isoforms of the 14-3-3 family and blocked the recruitment of HAT1 and RBBP7 to the unmodified H3-tail.	Tetradecanoylphorbol Acetate	109-112	histone acetyltransferase 1	Homo sapiens	200-204
27057553-5	2015	MSU crystals, PMA, and H2O2 induced the release of S100A8, S100A9, and S100A12 homodimers, as well as S100A8/A9 heterodimer.	Tetradecanoylphorbol Acetate	14-17	S100 calcium binding protein A8	Homo sapiens	51-57
27057553-5	2015	MSU crystals, PMA, and H2O2 induced the release of S100A8, S100A9, and S100A12 homodimers, as well as S100A8/A9 heterodimer.	Tetradecanoylphorbol Acetate	14-17	S100 calcium binding protein A8	Homo sapiens	102-108
25543044-6	2014	OBJECTIVE: The aim of the present study was to investigate whether crude ethanolic extracts of Zingiber cassumunar (CEZE) suppress phorbol12-myristate 13-acetate (PMA)-induced mucin production and gene expression in human airway epithelial cells and if so, to examine whether the suppression of mucin gene expression is mediated via the mitogen-activated protein kinase (MAPK) signal transduction pathways.	Tetradecanoylphorbol Acetate	131-161	LOC100508689	Homo sapiens	176-181
25543044-6	2014	OBJECTIVE: The aim of the present study was to investigate whether crude ethanolic extracts of Zingiber cassumunar (CEZE) suppress phorbol12-myristate 13-acetate (PMA)-induced mucin production and gene expression in human airway epithelial cells and if so, to examine whether the suppression of mucin gene expression is mediated via the mitogen-activated protein kinase (MAPK) signal transduction pathways.	Tetradecanoylphorbol Acetate	163-166	LOC100508689	Homo sapiens	176-181
25241246-0	2014	Down-regulation of MAPK/NF-kappaB signaling underlies anti-inflammatory response induced by transduced PEP-1-Prx2 proteins in LPS-induced Raw 264.7 and TPA-induced mouse ear edema model.	Tetradecanoylphorbol Acetate	152-155	peroxiredoxin 2	Mus musculus	109-113
25241246-7	2014	Transduced PEP-1-Prx2 suppressed intracellular ROS accumulation and inhibited the activity of MAPKs and NF-kappaB signaling that led to the suppression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and cytokines in LPS-induced Raw 264.7 cells and TPA-induced mouse ear edema model.	Tetradecanoylphorbol Acetate	269-272	peroxiredoxin 2	Mus musculus	17-21
25260594-8	2014	Further investigation disclosed that the AP-1 activator TPA-induced MMP9 activity and the TPA-promoted migration and invasion of hepatoma cells were significantly attenuated by miR-101 but were enhanced by miR-101 inhibitor.	Tetradecanoylphorbol Acetate	56-59	microRNA 101a	Mus musculus	177-184
25260594-8	2014	Further investigation disclosed that the AP-1 activator TPA-induced MMP9 activity and the TPA-promoted migration and invasion of hepatoma cells were significantly attenuated by miR-101 but were enhanced by miR-101 inhibitor.	Tetradecanoylphorbol Acetate	56-59	microRNA 101a	Mus musculus	206-213
25260594-8	2014	Further investigation disclosed that the AP-1 activator TPA-induced MMP9 activity and the TPA-promoted migration and invasion of hepatoma cells were significantly attenuated by miR-101 but were enhanced by miR-101 inhibitor.	Tetradecanoylphorbol Acetate	90-93	microRNA 101a	Mus musculus	177-184
25115801-3	2014	In neutrophils isolated from 20 healthy subjects, we assessed the effect of BNP on the "neutrophil burst" (O2 (-) production and MPO release) stimulated by phorbol myristate acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (fMLP), respectively.	Tetradecanoylphorbol Acetate	156-181	natriuretic peptide B	Homo sapiens	76-79
25178676-5	2014	We demonstrated that IL-32alpha interacts with protein kinase C (PKC)delta and PKCe in a phorbol 12-myristate 13-acetate (PMA) dependent way, and that PKCe regulates the interaction of IL-32alpha with PLZF.	Tetradecanoylphorbol Acetate	89-120	protein kinase C delta	Homo sapiens	65-74
25178676-5	2014	We demonstrated that IL-32alpha interacts with protein kinase C (PKC)delta and PKCe in a phorbol 12-myristate 13-acetate (PMA) dependent way, and that PKCe regulates the interaction of IL-32alpha with PLZF.	Tetradecanoylphorbol Acetate	122-125	protein kinase C delta	Homo sapiens	65-74
25000305-2	2014	The synthesis and secretion of MMP-9 can be stimulated by a variety of stimuli, including cytokines and phorbol 12-myristate 13-acetate (PMA), during various pathological processes, such as tumor invasion, atherosclerosis, inflammation, and rheumatoid arthritis, whereas MMP-2 is usually expressed constitutively.	Tetradecanoylphorbol Acetate	137-140	matrix metallopeptidase 2	Homo sapiens	271-276
24801891-5	2014	Phorbol myristate acetate-stimulated whole blood interleukin (IL)-4, IL-5, IL-10, IL-12, IL-13, IL-17A, IL-17F, IL-22, and interferon-gamma secretory responses were analyzed for associations comparing participants with allergic vs nonallergic asthma phenotypes with those without asthma.	Tetradecanoylphorbol Acetate	0-25	interleukin 5	Homo sapiens	69-73
24801891-5	2014	Phorbol myristate acetate-stimulated whole blood interleukin (IL)-4, IL-5, IL-10, IL-12, IL-13, IL-17A, IL-17F, IL-22, and interferon-gamma secretory responses were analyzed for associations comparing participants with allergic vs nonallergic asthma phenotypes with those without asthma.	Tetradecanoylphorbol Acetate	0-25	interleukin 17F	Homo sapiens	104-110
24962779-6	2014	In a DMBA/TPA-induced mouse skin tumor model, inhibition of Rac1 activity and depletion of CD11b+Gr1+ cells resulted in significant tumor formation.	Tetradecanoylphorbol Acetate	10-13	Rac family small GTPase 1	Mus musculus	60-64
23852815-9	2014	All tested compounds decreased TPA-induced c-jun mRNA levels in skin.	Tetradecanoylphorbol Acetate	31-34	jun proto-oncogene	Mus musculus	43-48
23852815-10	2014	DES, FA, and RU24858, but not RU24782, were also able to reverse TPA-induced increases in the mRNA levels of COX-2 and iNOS.	Tetradecanoylphorbol Acetate	65-68	cytochrome c oxidase II, mitochondrial	Mus musculus	109-114
24843010-5	2014	The exacerbated TPA response could be normalised by blocking TSLP or the immunoreceptor NKG2D but not CD4+ T cells.	Tetradecanoylphorbol Acetate	16-19	thymic stromal lymphopoietin	Mus musculus	61-65
24843010-5	2014	The exacerbated TPA response could be normalised by blocking TSLP or the immunoreceptor NKG2D but not CD4+ T cells.	Tetradecanoylphorbol Acetate	16-19	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	88-93
24378536-4	2014	The co-incubation of PMA with visfatin-induced CD36 expression with a concomitant increase in the phagocytosis of latex beads compared with PMA alone treatment.	Tetradecanoylphorbol Acetate	21-24	nicotinamide phosphoribosyltransferase	Homo sapiens	30-38
24406248-7	2014	Additional differentiation inducers, phorbol 12-myristate 13-acetate and dimethyl sulfoxide, also triggered GSK-3beta-dependent apoptosis.	Tetradecanoylphorbol Acetate	37-68	glycogen synthase kinase 3 beta	Homo sapiens	108-117
24519900-5	2014	The data obtained with O(6) -methylguanine-DNA methyltransferase (MGMT) overexpressing mice in which papillomas were induced by a single topical treatment with N-methyl-N-nitrosourea (MNU) followed by promotion with 12-O-tetradecanoylphorbol-13-acetate are reported.	Tetradecanoylphorbol Acetate	216-252	O-6-methylguanine-DNA methyltransferase	Mus musculus	23-64
24523905-4	2014	Here we show that phorbol 12-myristate 13-acetate (PMA) and cytokines increased p300 histone acetyltransferase activity to a higher magnitude (&gt; 2 fold) in quiescent fibroblasts than in proliferative fibroblasts.	Tetradecanoylphorbol Acetate	18-49	E1A binding protein p300	Homo sapiens	80-84
24523905-4	2014	Here we show that phorbol 12-myristate 13-acetate (PMA) and cytokines increased p300 histone acetyltransferase activity to a higher magnitude (&gt; 2 fold) in quiescent fibroblasts than in proliferative fibroblasts.	Tetradecanoylphorbol Acetate	51-54	E1A binding protein p300	Homo sapiens	80-84
24523905-8	2014	Silencing of tryptophan hydroxylase-1 or hydroxyindole O-methyltransferase in proliferative fibroblasts with siRNA resulted in elevation of PMA-induced p300 histone acetyltransferase activity to the level of that in quiescent fibroblasts, which was rescued by addition of 5-hydroxytryptophan or 5-methoxytryptophan.	Tetradecanoylphorbol Acetate	140-143	E1A binding protein p300	Homo sapiens	152-156
27599715-2	2016	We here report that stimulation of lung epithelial A549 tumor cells with phorbol-12-myristate-13-acetate (PMA) leads to the downregulation of the surface expressed mature form of ADAM17 without affecting ADAM10 expression.	Tetradecanoylphorbol Acetate	73-104	ADAM metallopeptidase domain 10	Homo sapiens	204-210
24439526-0	2014	Histone deacetylase inhibitor- and PMA-induced upregulation of PMCA4b enhances Ca2+ clearance from MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	35-38	ATPase plasma membrane Ca2+ transporting 4	Homo sapiens	63-69
24060215-4	2014	The results were as follows: (1) aqueous extract of Liriope Tuber stimulated basal mucin production and did not inhibit but increased PMA-induced mucin production; (2) ophiopogonin D and spicatoside A stimulated basal mucin production and did not inhibit but increased PMA-induced mucin production; (3) two compounds increased PMA-induced mucin secretion.	Tetradecanoylphorbol Acetate	134-137	LOC100508689	Homo sapiens	146-151
27599715-2	2016	We here report that stimulation of lung epithelial A549 tumor cells with phorbol-12-myristate-13-acetate (PMA) leads to the downregulation of the surface expressed mature form of ADAM17 without affecting ADAM10 expression.	Tetradecanoylphorbol Acetate	106-109	ADAM metallopeptidase domain 10	Homo sapiens	204-210
24060215-4	2014	The results were as follows: (1) aqueous extract of Liriope Tuber stimulated basal mucin production and did not inhibit but increased PMA-induced mucin production; (2) ophiopogonin D and spicatoside A stimulated basal mucin production and did not inhibit but increased PMA-induced mucin production; (3) two compounds increased PMA-induced mucin secretion.	Tetradecanoylphorbol Acetate	134-137	LOC100508689	Homo sapiens	146-151
24060215-4	2014	The results were as follows: (1) aqueous extract of Liriope Tuber stimulated basal mucin production and did not inhibit but increased PMA-induced mucin production; (2) ophiopogonin D and spicatoside A stimulated basal mucin production and did not inhibit but increased PMA-induced mucin production; (3) two compounds increased PMA-induced mucin secretion.	Tetradecanoylphorbol Acetate	134-137	LOC100508689	Homo sapiens	146-151
24060215-4	2014	The results were as follows: (1) aqueous extract of Liriope Tuber stimulated basal mucin production and did not inhibit but increased PMA-induced mucin production; (2) ophiopogonin D and spicatoside A stimulated basal mucin production and did not inhibit but increased PMA-induced mucin production; (3) two compounds increased PMA-induced mucin secretion.	Tetradecanoylphorbol Acetate	134-137	LOC100508689	Homo sapiens	146-151
24383758-8	2014	In further experiments, the micro(mu)-plasmin-KD1L17R-KT complex inhibited urokinase-induced plasminogen activation on phorbol-12-myristate-13-acetate-stimulated U937 monocyte-like cells, whereas the mu-plasmin-KD1L17R-VT complex failed to inhibit this process.	Tetradecanoylphorbol Acetate	119-150	plasminogen	Homo sapiens	38-45
24383758-8	2014	In further experiments, the micro(mu)-plasmin-KD1L17R-KT complex inhibited urokinase-induced plasminogen activation on phorbol-12-myristate-13-acetate-stimulated U937 monocyte-like cells, whereas the mu-plasmin-KD1L17R-VT complex failed to inhibit this process.	Tetradecanoylphorbol Acetate	119-150	plasminogen	Homo sapiens	93-100
27374227-8	2016	Inhibition of ERK/MAPK pathway with PD98059 potently blocked N2a cell neurite outgrowth, whereas phorbol 12-myristate 13-acetate-induced ERK activation rescued defects in neurite outgrowth and cell death induced by Malat1 depletion.	Tetradecanoylphorbol Acetate	97-128	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	215-221
24380573-0	2014	Naturally occurring phenolic acids modulate TPA-induced activation of EGFR, AP-1, and STATs in mouse epidermis.	Tetradecanoylphorbol Acetate	44-47	jun proto-oncogene	Mus musculus	76-80
24380573-2	2014	In this study we investigated the possible interference of naturally occurring phenolic acids with EGFR, activator protein-1 (AP-1), and signal transducers and activators of transcription (STATs) pathways activated by topical application of tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Balb/c mice epidermis.	Tetradecanoylphorbol Acetate	256-292	jun proto-oncogene	Mus musculus	105-124
27777559-11	2016	Conclusion: Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	113-116	MYD88 innate immune signal transduction adaptor	Homo sapiens	75-80
24353864-0	2013	Effect of Epigallocatechin-3-Gallate on PMA-Induced MUC5B Expression in Human Airway Epithelial Cells.	Tetradecanoylphorbol Acetate	40-43	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	52-57
24353864-1	2013	OBJECTIVES: Among the inflammatory mediators, phorbol 12-myristate 13-acetate (PMA) is associated with the regulation of MUC5B expression in the airway epithelial cells.	Tetradecanoylphorbol Acetate	46-77	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	121-126
24196830-9	2014	Combinations of metformin and rapamycin were more effective at blocking epidermal mTORC1 signaling induced by TPA consistent with the greater inhibitory effect on skin tumor promotion.	Tetradecanoylphorbol Acetate	110-113	CREB regulated transcription coactivator 1	Mus musculus	82-88
27409664-6	2016	Furthermore, downregulation of CTBP1 by miR-644a upregulates wild type- or mutant-p53 which acts as a "molecular switch" between G1-arrest and apoptosis by inducing cyclin-dependent kinase inhibitor 1 (p21, CDKN1A, CIP1) or pro-apoptotic phorbol-12-myristate-13-acetate-induced protein 1 (Noxa, PMAIP1), respectively.	Tetradecanoylphorbol Acetate	238-269	C-terminal binding protein 1	Homo sapiens	31-36
24190483-6	2014	Osteosarcoma and rhabdomyosarcoma showed bands corresponding to MMP-2 and -9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	123-154	matrix metallopeptidase 2	Homo sapiens	64-76
24353864-1	2013	OBJECTIVES: Among the inflammatory mediators, phorbol 12-myristate 13-acetate (PMA) is associated with the regulation of MUC5B expression in the airway epithelial cells.	Tetradecanoylphorbol Acetate	79-82	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	121-126
24353864-10	2013	In addition, SB203580 and MMP-9 I (MMP-9 inhibitor) significantly decreased PMA-induced MUC5B expression.	Tetradecanoylphorbol Acetate	76-79	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	88-93
24190483-6	2014	Osteosarcoma and rhabdomyosarcoma showed bands corresponding to MMP-2 and -9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	156-159	matrix metallopeptidase 2	Homo sapiens	64-76
27426034-4	2016	The phenomenon could be mimicked by either transfecting a mutant form of ANXA1 with its serine 27 residue converted to aspartic acid, S27D, or by using the PKC agonist, phorbol 12-myristate 13-acetate (PMA) in these microglial cells.	Tetradecanoylphorbol Acetate	202-205	annexin A1	Mus musculus	73-78
23792458-3	2014	Mice lacking epidermal Cd151 developed fewer and smaller tumors than wild-type mice after treatment with 7,12-dimethylbenzanthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	140-176	CD151 antigen	Mus musculus	23-28
23792458-3	2014	Mice lacking epidermal Cd151 developed fewer and smaller tumors than wild-type mice after treatment with 7,12-dimethylbenzanthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	178-181	CD151 antigen	Mus musculus	23-28
23792458-4	2014	Furthermore, Cd151-null epidermis showed a reduced hyperproliferative response to short-term treatment with TPA as compared with wild-type skin, whereas epidermal turnover was increased.	Tetradecanoylphorbol Acetate	108-111	CD151 antigen	Mus musculus	13-18
24085323-5	2013	Fibrosarcoma, chondrosarcoma, liposarcoma and synovial sarcoma showed bands corresponding to MMP-2 and MMP-9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	155-186	matrix metallopeptidase 2	Homo sapiens	93-98
24085323-5	2013	Fibrosarcoma, chondrosarcoma, liposarcoma and synovial sarcoma showed bands corresponding to MMP-2 and MMP-9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	188-191	matrix metallopeptidase 2	Homo sapiens	93-98
27364328-7	2016	mCherry/GFP ratio imaging of phorbol-12-myristate-13-acetate-stimulated N-CISSOR-expressing HEK293T cells enabled to monitor rapid ectodomain shedding of NRG1 at the subcellular level.	Tetradecanoylphorbol Acetate	29-60	neuregulin 1	Homo sapiens	154-158
24205091-8	2013	AE-BCT also dramatically suppressed PMA-induced MMP-9 activity and expression by blocking NF-kappaB activation and ERK phosphorylation.	Tetradecanoylphorbol Acetate	36-39	matrix metallopeptidase 9	Mus musculus	48-53
23792458-6	2014	We suggest that DMBA-initiated keratinocytes lacking Cd151 leave their niches in the epidermis and hair follicles in response to TPA treatment and subsequently are lost by differentiation.	Tetradecanoylphorbol Acetate	129-132	CD151 antigen	Mus musculus	53-58
23792458-9	2014	We thus identify CD151 as a critical factor in TPA-dependent skin carcinogenesis.	Tetradecanoylphorbol Acetate	47-50	CD151 antigen	Mus musculus	17-22
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	prostaglandin-endoperoxide synthase 2	Mus musculus	255-271
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	prostaglandin-endoperoxide synthase 2	Mus musculus	273-278
23983093-6	2014	These findings first demonstrate that flavonoid-rich A. communis may exert potent anti-inflammatory activity through modulation of COX-2 in TPA-activated skin and tumor tissues.	Tetradecanoylphorbol Acetate	140-143	prostaglandin-endoperoxide synthase 2	Mus musculus	131-136
23940030-6	2013	In addition, FBXO25 overexpression suppressed induction of two ELK-1 target genes, c-fos and egr-1, in response to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	115-146	F-box protein 25	Homo sapiens	13-19
27330189-3	2016	Squamous tumors also erupted spontaneously on the skin of MT-HGF mice that were promoted by wounding or the application of 12-O-tetradecanoylphorbol 13-acetate, an activator of protein kinase C. Carcinogen-initiated tumors had Ras mutations, but spontaneous tumors did not.	Tetradecanoylphorbol Acetate	123-159	hepatocyte growth factor	Homo sapiens	61-64
24023832-7	2013	Phorbol 12-myristate 13-acetate (PMA), the most commonly used phorbol ester, binds to and activates protein kinase C (PKC), causing a wide range of effects in cells and tissues.	Tetradecanoylphorbol Acetate	0-31	protein kinase C delta	Homo sapiens	118-121
24023832-7	2013	Phorbol 12-myristate 13-acetate (PMA), the most commonly used phorbol ester, binds to and activates protein kinase C (PKC), causing a wide range of effects in cells and tissues.	Tetradecanoylphorbol Acetate	33-36	protein kinase C delta	Homo sapiens	118-121
23835587-8	2013	DMBA/TPA application resulted in significant increases in c-jun and p50, which were reversed by a number of different treatments.	Tetradecanoylphorbol Acetate	5-8	jun proto-oncogene	Mus musculus	58-63
23835587-8	2013	DMBA/TPA application resulted in significant increases in c-jun and p50, which were reversed by a number of different treatments.	Tetradecanoylphorbol Acetate	5-8	dynactin 2	Mus musculus	68-71
23835587-9	2013	DMBA/TPA treatment also strongly increased mRNA levels of inflammation markers COX-2 and IL-6.	Tetradecanoylphorbol Acetate	5-8	cytochrome c oxidase II, mitochondrial	Mus musculus	79-84
23988002-7	2013	Patients with this condition form normal blood clots that are quickly lysed by unopposed tPA-activated plasmin.	Tetradecanoylphorbol Acetate	89-92	plasminogen	Homo sapiens	103-110
23715155-6	2013	Both one-photon absorption (OPA) in Ag2S and two-photon absorption (TPA) in graphene played important roles in RSA processes of the G/Ag2S/PMMA organic glasses.	Tetradecanoylphorbol Acetate	68-71	angiotensin II receptor type 1	Homo sapiens	134-138
23424156-11	2013	TLC and phorbol myristate acetate increased cytosolic pMARCKS and decreased PM-MARCKS in HuH-NTCP cells.	Tetradecanoylphorbol Acetate	8-33	myristoylated alanine rich protein kinase C substrate	Homo sapiens	55-61
23644754-8	2013	We observed that NKL.Foxp3 cells inhibited the proliferation and activation of phorbol-12-myristate-13-acetate/ionomycin-stimulated hPBMCs; furthermore, NKL.Foxp3 cells significantly suppressed the delayed-type hypersensitivity response, which was induced by anti-CD3 monoclonal antibody-activated hPBMCs.	Tetradecanoylphorbol Acetate	79-110	forkhead box P3	Homo sapiens	21-26
23644754-8	2013	We observed that NKL.Foxp3 cells inhibited the proliferation and activation of phorbol-12-myristate-13-acetate/ionomycin-stimulated hPBMCs; furthermore, NKL.Foxp3 cells significantly suppressed the delayed-type hypersensitivity response, which was induced by anti-CD3 monoclonal antibody-activated hPBMCs.	Tetradecanoylphorbol Acetate	79-110	forkhead box P3	Homo sapiens	157-162
23385063-5	2013	Notably, AcEGCG not only inhibited the expression of p53, p21, c-Myc, cyclin B, p-CDK1 and Cdc25A but also restored the activation of extracellular signal-regulated kinase 1/2 (ERK1/2), which decreased DMBA/TPA-induced increases in tumor proliferation and mitotic index.	Tetradecanoylphorbol Acetate	207-210	mitogen-activated protein kinase 3	Mus musculus	134-175
23429041-4	2013	DHA dose-dependently decreased PMA-induced COX-2 expression and PGE2 production, as well as COX-2 promoter-driven luciferase activity.	Tetradecanoylphorbol Acetate	31-34	cytochrome c oxidase II, mitochondrial	Mus musculus	43-48
23429041-6	2013	DHA also remarkably reduced PMA-induced p65, C/EBPbeta, c-jun and CREB nuclear translocation.	Tetradecanoylphorbol Acetate	28-31	jun proto-oncogene	Mus musculus	56-61
23429041-7	2013	Furthermore, DHA evidently inhibited PMA-induced phosphorylation of AKT and the MAP Kinases, such as ERK, JNK and p38.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 14	Mus musculus	114-117
23563849-11	2013	MSTO-211H showed two bands, an intense band corresponding to MMP-2 and a faint band corresponding to MMP-9; MMP-9 was enhanced significantly with PMA treatment.	Tetradecanoylphorbol Acetate	146-149	matrix metallopeptidase 2	Homo sapiens	61-66
23708096-2	2013	Topical application of LicE (0.5-2 mg) effectively inhibited TPA-induced (1) ear edema formation; (2) phosphorylation of stress-activated protein kinase/c-Jun-N-terminal kinase (SAPK/JNK), c-Jun, and extracellular signal regulated kinase 1/2; and (3) expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins in mouse skin.	Tetradecanoylphorbol Acetate	61-64	mitogen-activated protein kinase 3	Mus musculus	200-241
23708096-2	2013	Topical application of LicE (0.5-2 mg) effectively inhibited TPA-induced (1) ear edema formation; (2) phosphorylation of stress-activated protein kinase/c-Jun-N-terminal kinase (SAPK/JNK), c-Jun, and extracellular signal regulated kinase 1/2; and (3) expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins in mouse skin.	Tetradecanoylphorbol Acetate	61-64	cytochrome c oxidase II, mitochondrial	Mus musculus	308-330
23114726-7	2013	The treatment of specific inhibitor for ERK (U0126) to MCF-7 cells could inhibit TPA-induced MMP-2/MMP-9 and phospho-ERK along with an inhibition on cell invasion and migration.	Tetradecanoylphorbol Acetate	81-84	matrix metallopeptidase 2	Homo sapiens	93-98
23377348-8	2013	MARCKS translocated rapidly from plasma membrane to cytoplasm, whereas HSP70 was observed in the cytoplasm and appeared to associate with MARCKS after PMA exposure.	Tetradecanoylphorbol Acetate	151-154	myristoylated alanine rich protein kinase C substrate	Homo sapiens	138-144
23594483-0	2013	4-Methylumbelliferone inhibits the phosphorylation of hyaluronan synthase 2 induced by 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	87-124	hyaluronan synthase 2	Homo sapiens	54-75
23333628-3	2013	Recently, we demonstrated that histamine or phorbol-12-myristate-13-acetate (PMA) stimulation induced the up-regulation of H1R gene expression through the protein kinase Cdelta (PKCdelta)/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells expressing H1R endogenously.	Tetradecanoylphorbol Acetate	44-75	protein kinase C delta	Homo sapiens	155-176
23333628-3	2013	Recently, we demonstrated that histamine or phorbol-12-myristate-13-acetate (PMA) stimulation induced the up-regulation of H1R gene expression through the protein kinase Cdelta (PKCdelta)/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells expressing H1R endogenously.	Tetradecanoylphorbol Acetate	44-75	protein kinase C delta	Homo sapiens	178-186
23333628-3	2013	Recently, we demonstrated that histamine or phorbol-12-myristate-13-acetate (PMA) stimulation induced the up-regulation of H1R gene expression through the protein kinase Cdelta (PKCdelta)/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells expressing H1R endogenously.	Tetradecanoylphorbol Acetate	77-80	protein kinase C delta	Homo sapiens	155-176
23333628-3	2013	Recently, we demonstrated that histamine or phorbol-12-myristate-13-acetate (PMA) stimulation induced the up-regulation of H1R gene expression through the protein kinase Cdelta (PKCdelta)/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells expressing H1R endogenously.	Tetradecanoylphorbol Acetate	77-80	protein kinase C delta	Homo sapiens	178-186
23440225-3	2013	Activation of PKC by phorbol 12-myristate 13-acetate (PMA) causes activation of extracellular signal-regulated kinase (ERK) and promotes the formation of new spines in cultured hippocampal neurons.	Tetradecanoylphorbol Acetate	21-52	protein kinase C delta	Homo sapiens	14-17
23440225-3	2013	Activation of PKC by phorbol 12-myristate 13-acetate (PMA) causes activation of extracellular signal-regulated kinase (ERK) and promotes the formation of new spines in cultured hippocampal neurons.	Tetradecanoylphorbol Acetate	54-57	protein kinase C delta	Homo sapiens	14-17
23440225-4	2013	The purpose of this study was to examine which PKC isoforms are responsible for the PMA-induced augmentation of long-term potentiation (LTP) in the CA1 stratum radiatum of the hippocampus in vitro and verify that this facilitation requires NMDAR activation.	Tetradecanoylphorbol Acetate	84-87	protein kinase C delta	Homo sapiens	47-50
23440225-6	2013	Facilitation of LTP by PMA (200 nM) was blocked by the nonspecific PKC inhibitor, Ro 31-8220 (10microM); the selective PKCdelta inhibitor, rottlerin (1microM); and the PKCepsilon inhibitor, TAT-epsilonV1-2 peptide (500 nM).	Tetradecanoylphorbol Acetate	23-26	protein kinase C delta	Homo sapiens	67-70
23440225-6	2013	Facilitation of LTP by PMA (200 nM) was blocked by the nonspecific PKC inhibitor, Ro 31-8220 (10microM); the selective PKCdelta inhibitor, rottlerin (1microM); and the PKCepsilon inhibitor, TAT-epsilonV1-2 peptide (500 nM).	Tetradecanoylphorbol Acetate	23-26	protein kinase C delta	Homo sapiens	119-127
23563532-4	2013	The TPA-induced mice ear edema model, indicated that treating with the GGS extract inhibited the expression levels of such inflammatory mediators as cyclooxygenase-2 and inducible nitric oxide synthase.	Tetradecanoylphorbol Acetate	4-7	prostaglandin-endoperoxide synthase 2	Mus musculus	149-201
23530644-6	2013	To elucidate the mechanisms underlying the antiinflammatory and antitumor promotion activity of the Y-grape juice, the effect of Y-grape juice on cyclooxygenase-2 (COX-2) activity in mouse ear treated with TPA was studied.	Tetradecanoylphorbol Acetate	206-209	prostaglandin-endoperoxide synthase 2	Mus musculus	146-162
23530644-7	2013	Both topical and oral application of the Y-grape juice inhibited the TPA-induced increase in COX-2 activity.	Tetradecanoylphorbol Acetate	69-72	prostaglandin-endoperoxide synthase 2	Mus musculus	93-98
23457529-10	2013	Additionally, in vivo experiments confirmed that COX-2 and COX-2 downstream factors were elevated in TPA-treated Tpl2(-/-) skin, as well as in papillomas from Tpl2(-/-) mice.	Tetradecanoylphorbol Acetate	101-104	prostaglandin-endoperoxide synthase 2	Mus musculus	49-54
23457529-10	2013	Additionally, in vivo experiments confirmed that COX-2 and COX-2 downstream factors were elevated in TPA-treated Tpl2(-/-) skin, as well as in papillomas from Tpl2(-/-) mice.	Tetradecanoylphorbol Acetate	101-104	prostaglandin-endoperoxide synthase 2	Mus musculus	59-64
22782996-6	2012	Follow-up studies revealed that Tnf, Nfkb1, Il22, Il1b, Cxcl1, Cxcl2 and Cxcl5 mRNAs were highly expressed in epidermis of DBA/2 compared with C57BL/6 mice at 24h following treatment with TPA.	Tetradecanoylphorbol Acetate	188-191	chemokine (C-X-C motif) ligand 5	Mus musculus	73-78
22713854-3	2012	hCG or forskolin+PMA induced the transient increase in Runx1, Ptgs2, and Tnfaip6 expression, while the expression of Runx2 continued to increase until 48 h. The knockdown of the agonist-stimulated Runx2 expression increased Runx1, Ptgs2, and Tnfaip6 expression and PGE(2) levels in luteinizing granulosa cells.	Tetradecanoylphorbol Acetate	17-20	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	62-67
22713854-3	2012	hCG or forskolin+PMA induced the transient increase in Runx1, Ptgs2, and Tnfaip6 expression, while the expression of Runx2 continued to increase until 48 h. The knockdown of the agonist-stimulated Runx2 expression increased Runx1, Ptgs2, and Tnfaip6 expression and PGE(2) levels in luteinizing granulosa cells.	Tetradecanoylphorbol Acetate	17-20	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	231-236
22773863-3	2012	TPA (3 mug per ear) induced acute skin inflammation in the ears of C57BL/6 mice, including edema, infiltration of granulocytes but not T cells, and IFN-gamma receptor 1-mediated deregulation of intercellular adhesion molecule 1 (CD54).	Tetradecanoylphorbol Acetate	0-3	interferon gamma receptor 1	Mus musculus	148-168
22773863-3	2012	TPA (3 mug per ear) induced acute skin inflammation in the ears of C57BL/6 mice, including edema, infiltration of granulocytes but not T cells, and IFN-gamma receptor 1-mediated deregulation of intercellular adhesion molecule 1 (CD54).	Tetradecanoylphorbol Acetate	0-3	intercellular adhesion molecule 1	Mus musculus	194-227
24399942-6	2013	A PKC delta/theta inhibitor antagonized PMA-induced reduction of ethanol excitation.	Tetradecanoylphorbol Acetate	40-43	protein kinase C delta	Homo sapiens	2-5
23957209-1	2013	UNLABELLED: Superoxide production by Nox1, a member of the Nox family NAPDH oxidases, requires expression of its regulatory soluble proteins Noxo1 (Nox organizer 1) and Noxa1 (Nox activator 1) and is markedly enhanced upon cell stimulation with phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	245-276	NADPH oxidase 1	Homo sapiens	37-41
23957209-4	2013	Among them, Thr341 in Noxo1 is directly phosphorylated by PKC in vitro, and alanine substitution for this residue reduces not only PMA-induced Noxo1 phosphorylation but also PMA-dependent enhancement of Nox1-catalyzed superoxide production.	Tetradecanoylphorbol Acetate	131-134	NADPH oxidase 1	Homo sapiens	203-207
23957209-4	2013	Among them, Thr341 in Noxo1 is directly phosphorylated by PKC in vitro, and alanine substitution for this residue reduces not only PMA-induced Noxo1 phosphorylation but also PMA-dependent enhancement of Nox1-catalyzed superoxide production.	Tetradecanoylphorbol Acetate	174-177	NADPH oxidase 1	Homo sapiens	203-207
23770196-7	2013	Furthermore, topical application of PEP-1-SIRT2 to 12-O-tetradecanoylphorbol 13-acetate-treated mouse ears markedly inhibited expression levels of COX-2 and proinflammatory cytokines as well as the activation of NF-kappaB and MAPKs.	Tetradecanoylphorbol Acetate	51-87	cytochrome c oxidase II, mitochondrial	Mus musculus	147-152
23913682-5	2013	12-O-Tetradecanoylphorbol-13-acetate induced the expression of both KLF5 and mPGES1 in dosage- and time-dependent manners.	Tetradecanoylphorbol Acetate	0-36	Kruppel like factor 5	Homo sapiens	68-72
23913682-6	2013	The induction of KLF5 was essential for 12-O-tetradecanoylphorbol-13-acetate to induce mPGES1 expression.	Tetradecanoylphorbol Acetate	40-76	Kruppel like factor 5	Homo sapiens	17-21
23773897-4	2013	Phorbol 12-myristate 13-acetate (PMA) strongly suppressed proliferation of Res-HL60, downregulated CD14, and affected mRNA expression.	Tetradecanoylphorbol Acetate	0-31	CD14 molecule	Homo sapiens	99-103
23773897-4	2013	Phorbol 12-myristate 13-acetate (PMA) strongly suppressed proliferation of Res-HL60, downregulated CD14, and affected mRNA expression.	Tetradecanoylphorbol Acetate	33-36	CD14 molecule	Homo sapiens	99-103
23936765-1	2013	RSK2 is a p90 ribosomal S6 kinase family (p90(RSK)) member regulating cell proliferation and transformation induced by tumor promoters such as epithelial growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	178-214	ribosomal protein S6 kinase A3	Homo sapiens	0-4
23936765-1	2013	RSK2 is a p90 ribosomal S6 kinase family (p90(RSK)) member regulating cell proliferation and transformation induced by tumor promoters such as epithelial growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	178-214	ribosomal protein S6 kinase A3	Homo sapiens	42-50
23584792-10	2013	Forskolin (FSK)/phorbol 12-myristate 13-acetate (PMA), to mimic PGE(2), resulted in a further significant increase in PII activity with all CRTCs, with CRTC2 and CRTC3 having greater effects.	Tetradecanoylphorbol Acetate	16-47	CREB regulated transcription coactivator 3	Homo sapiens	162-167
23584792-10	2013	Forskolin (FSK)/phorbol 12-myristate 13-acetate (PMA), to mimic PGE(2), resulted in a further significant increase in PII activity with all CRTCs, with CRTC2 and CRTC3 having greater effects.	Tetradecanoylphorbol Acetate	49-52	CREB regulated transcription coactivator 3	Homo sapiens	162-167
23584792-12	2013	Moreover, gene silencing of CRTC2 and CRTC3 significantly reduced the FSK/PMA-mediated stimulation of aromatase activity.	Tetradecanoylphorbol Acetate	74-77	CREB regulated transcription coactivator 3	Homo sapiens	38-43
23869208-7	2013	CD14(hi) and CD14(lo) M1- and M2-like MPhis were generated in vitro from the THP-1 monocyte cell line by differentiation with PMA and vitamin D3, respectively.	Tetradecanoylphorbol Acetate	126-129	CD14 molecule	Homo sapiens	0-4
24152847-10	2013	The protein kinase C activators phorbol diester (PMA) and bryostatin 1 (Bryo1) stimulated basophils to rapidly release a large amount of Ang1.	Tetradecanoylphorbol Acetate	49-52	angiopoietin 1	Homo sapiens	137-141
23566487-2	2013	The obtained data showed that starvation (24-96 h), exposure to 10nM TPA, and low concentrations (0.05-1 muM) of As2O3 significantly (3-5 times) upregulated Paju cell STC-1 RNA and stabilized the mitochondrial membrane potential (MMP).	Tetradecanoylphorbol Acetate	69-72	stanniocalcin 1	Homo sapiens	167-172
23399806-8	2013	Interestingly, GOH also inhibited TPA induced altered activity of p38MAPK.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 14	Mus musculus	66-73
23399806-9	2013	Further, TPA induced altered expression of NF-kappaB (p65) and COX-2 was also attenuated by GOH.	Tetradecanoylphorbol Acetate	9-12	cytochrome c oxidase II, mitochondrial	Mus musculus	63-68
24265865-5	2013	Therefore, we investigated the involvement of 12-O-Tetradecanoylphorbol 13-acetate in the expression of OPG in MG-63 osteosarcoma cells.	Tetradecanoylphorbol Acetate	46-82	TNF receptor superfamily member 11b	Homo sapiens	104-107
24265865-8	2013	12-O-Tetradecanoylphorbol 13-acetate also induced OPG and Tgase-2 expression.	Tetradecanoylphorbol Acetate	0-36	TNF receptor superfamily member 11b	Homo sapiens	50-53
24265865-15	2013	All together, OPG and Tgase-2 is induced by IL-1beta or TPA in MG-63 cells and Tgase-2 is involved in OPG expression in MG-63 cells.	Tetradecanoylphorbol Acetate	56-59	TNF receptor superfamily member 11b	Homo sapiens	14-17
23708096-2	2013	Topical application of LicE (0.5-2 mg) effectively inhibited TPA-induced (1) ear edema formation; (2) phosphorylation of stress-activated protein kinase/c-Jun-N-terminal kinase (SAPK/JNK), c-Jun, and extracellular signal regulated kinase 1/2; and (3) expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins in mouse skin.	Tetradecanoylphorbol Acetate	61-64	jun proto-oncogene	Mus musculus	153-158
23708096-2	2013	Topical application of LicE (0.5-2 mg) effectively inhibited TPA-induced (1) ear edema formation; (2) phosphorylation of stress-activated protein kinase/c-Jun-N-terminal kinase (SAPK/JNK), c-Jun, and extracellular signal regulated kinase 1/2; and (3) expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins in mouse skin.	Tetradecanoylphorbol Acetate	61-64	jun proto-oncogene	Mus musculus	189-194
23675462-5	2013	Here, we demonstrate that both MSK1 and MSK2, regulate the phorbol ester 12-O-tetradecanoylphorbol-13-acetate induced expression of the breast cancer marker gene, trefoil factor 1 (TFF1), by phosphorylating H3S10 at its 5" regulatory regions.	Tetradecanoylphorbol Acetate	73-109	ribosomal protein S6 kinase A5	Homo sapiens	31-35
23525112-3	2013	Inhibition of NF-kappaB reversed both H2O2- and phorbol 12-myristate 13-acetate (PMA)-induced decrease in TRPC6 protein expression.	Tetradecanoylphorbol Acetate	48-79	transient receptor potential cation channel subfamily C member 6	Homo sapiens	106-111
23525112-3	2013	Inhibition of NF-kappaB reversed both H2O2- and phorbol 12-myristate 13-acetate (PMA)-induced decrease in TRPC6 protein expression.	Tetradecanoylphorbol Acetate	81-84	transient receptor potential cation channel subfamily C member 6	Homo sapiens	106-111
23525112-11	2013	Moreover, PMA treatment increased the association of p65 with histone deacetylase (HDAC) and decreased histone acetylation at the TRPC6 promoter.	Tetradecanoylphorbol Acetate	10-13	RELA proto-oncogene, NF-kB subunit	Homo sapiens	53-56
23525112-11	2013	Moreover, PMA treatment increased the association of p65 with histone deacetylase (HDAC) and decreased histone acetylation at the TRPC6 promoter.	Tetradecanoylphorbol Acetate	10-13	transient receptor potential cation channel subfamily C member 6	Homo sapiens	130-135
23288142-6	2013	TPA-induced activation of ERK1, Akt, and PKCdelta was attenuated by DHA, whereas LA attenuated only ERK1 activation.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	41-49
22773863-3	2012	TPA (3 mug per ear) induced acute skin inflammation in the ears of C57BL/6 mice, including edema, infiltration of granulocytes but not T cells, and IFN-gamma receptor 1-mediated deregulation of intercellular adhesion molecule 1 (CD54).	Tetradecanoylphorbol Acetate	0-3	intercellular adhesion molecule 1	Mus musculus	229-233
22841871-5	2012	Pretreatment with PBPs 1-3 decreased TPA-induced translocation of PKC isozymes (alpha, beta, eta, gamma, epsilon) from cytosol to membrane, whereas PBPs 4 and 5 were less effective.	Tetradecanoylphorbol Acetate	37-40	endothelin receptor type A	Mus musculus	88-91
22623726-5	2012	Here, we demonstrate by live-cell imaging analysis that treatment of cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) induces endocytosis of subdomains of connexin43 gap junctions.	Tetradecanoylphorbol Acetate	80-116	gap junction protein alpha 1	Homo sapiens	160-170
27163640-7	2016	The cell motile activity of A375 cells treated with TPA was markedly increased by GPR120 knockdown.	Tetradecanoylphorbol Acetate	52-55	free fatty acid receptor 4	Homo sapiens	82-88
22623726-5	2012	Here, we demonstrate by live-cell imaging analysis that treatment of cells with 12-O-tetradecanoylphorbol 13-acetate (TPA) induces endocytosis of subdomains of connexin43 gap junctions.	Tetradecanoylphorbol Acetate	118-121	gap junction protein alpha 1	Homo sapiens	160-170
22623726-7	2012	The HECT E3 ubiquitin ligase smad ubiquitination regulatory factor-2 (Smurf2) was found to be recruited to connexin43 gap junctions in response to TPA treatment.	Tetradecanoylphorbol Acetate	147-150	gap junction protein alpha 1	Homo sapiens	107-117
27163640-9	2016	The long-term TPA treatment induced the high cell motile activity and elevated GPR120 and GPR40 expressions.	Tetradecanoylphorbol Acetate	14-17	free fatty acid receptor 4	Homo sapiens	79-85
27163640-10	2016	The high cell motile activity of A375 cells stimulated by the long-term TPA treatment was enhanced by GPR120 knockdown.	Tetradecanoylphorbol Acetate	72-75	free fatty acid receptor 4	Homo sapiens	102-108
27163640-11	2016	These results suggest that GPR120 negatively and GPR40 positively regulate cell motile activities induce by TPA in melanoma cells.	Tetradecanoylphorbol Acetate	108-111	free fatty acid receptor 4	Homo sapiens	27-33
22584576-11	2012	Only SFHFKSGSL, in PKCdelta-transfected phorbol 12-myristate 13-acetate-stimulated cells, caused membrane blebbing and cell loss.	Tetradecanoylphorbol Acetate	40-71	protein kinase C delta	Homo sapiens	19-27
27313511-4	2016	These cells exposed 1-4 days to low levels of H2O2 or to the protein kinase C (PKC) activator, phorbol-12-Myristate-13-Acetate (PMA) increased the expression of specific OL differentiation markers: the specific nuclear factor Olig-2, and Myelin Basic Protein (MBP), which was processed and accumulated selectively in membranes.	Tetradecanoylphorbol Acetate	95-126	oligodendrocyte transcription factor 2	Homo sapiens	226-232
22570253-8	2012	These CD137+PD-1High CD8+ T cells, persisted in irradiated AT-3 tumors, expressed Tim-3, granzyme B and Ki67 and produced IFN-gamma ex vivo in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin stimulation.	Tetradecanoylphorbol Acetate	155-186	interferon gamma	Sus scrofa	122-131
27313511-4	2016	These cells exposed 1-4 days to low levels of H2O2 or to the protein kinase C (PKC) activator, phorbol-12-Myristate-13-Acetate (PMA) increased the expression of specific OL differentiation markers: the specific nuclear factor Olig-2, and Myelin Basic Protein (MBP), which was processed and accumulated selectively in membranes.	Tetradecanoylphorbol Acetate	95-126	myelin basic protein	Homo sapiens	238-258
22716246-8	2012	Although the skin of Mgat5(-/-) mice appeared normal, epidermal hyperplasia and proliferation of keratinocytes induced by the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) were downregulated in these mutants.	Tetradecanoylphorbol Acetate	140-177	mannoside acetylglucosaminyltransferase 5	Mus musculus	21-26
27313511-4	2016	These cells exposed 1-4 days to low levels of H2O2 or to the protein kinase C (PKC) activator, phorbol-12-Myristate-13-Acetate (PMA) increased the expression of specific OL differentiation markers: the specific nuclear factor Olig-2, and Myelin Basic Protein (MBP), which was processed and accumulated selectively in membranes.	Tetradecanoylphorbol Acetate	95-126	myelin basic protein	Homo sapiens	260-263
22542552-6	2012	In addition, piperine inhibited PMA-induced NF-kappaB, C/EBP and c-Jun nuclear translocation.	Tetradecanoylphorbol Acetate	32-35	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	55-60
27313511-4	2016	These cells exposed 1-4 days to low levels of H2O2 or to the protein kinase C (PKC) activator, phorbol-12-Myristate-13-Acetate (PMA) increased the expression of specific OL differentiation markers: the specific nuclear factor Olig-2, and Myelin Basic Protein (MBP), which was processed and accumulated selectively in membranes.	Tetradecanoylphorbol Acetate	128-131	oligodendrocyte transcription factor 2	Homo sapiens	226-232
22542552-6	2012	In addition, piperine inhibited PMA-induced NF-kappaB, C/EBP and c-Jun nuclear translocation.	Tetradecanoylphorbol Acetate	32-35	jun proto-oncogene	Mus musculus	65-70
27313511-4	2016	These cells exposed 1-4 days to low levels of H2O2 or to the protein kinase C (PKC) activator, phorbol-12-Myristate-13-Acetate (PMA) increased the expression of specific OL differentiation markers: the specific nuclear factor Olig-2, and Myelin Basic Protein (MBP), which was processed and accumulated selectively in membranes.	Tetradecanoylphorbol Acetate	128-131	myelin basic protein	Homo sapiens	238-258
27313511-4	2016	These cells exposed 1-4 days to low levels of H2O2 or to the protein kinase C (PKC) activator, phorbol-12-Myristate-13-Acetate (PMA) increased the expression of specific OL differentiation markers: the specific nuclear factor Olig-2, and Myelin Basic Protein (MBP), which was processed and accumulated selectively in membranes.	Tetradecanoylphorbol Acetate	128-131	myelin basic protein	Homo sapiens	260-263
27258267-6	2016	Additionally, phorbol 12-myristate 13-acetate-induced macrophage differentiation of TLR10 knockdown cells was not affected in the knockdown cells.	Tetradecanoylphorbol Acetate	14-45	toll like receptor 10	Homo sapiens	84-89
22249765-5	2012	We show that MBP redistributes to distinct "membrane-ruffled" regions of the plasma membrane where it co-localizes with actin and tubulin, and with the SH3-domain-containing proteins cortactin and ZO-1, when stimulated with PMA, a potent activator of the protein kinase C pathway.	Tetradecanoylphorbol Acetate	224-227	myelin basic protein	Homo sapiens	13-16
21480396-8	2012	Both UVR and TPA treatment stimulated PKCepsilon-Stat3 interaction, Stat3Ser727 phosphorylation and Stat3-regulated gene COX-2 expression.	Tetradecanoylphorbol Acetate	13-16	cytochrome c oxidase II, mitochondrial	Mus musculus	121-126
27105502-8	2016	The in vitro study showed that MALT1 inhibitors decreased production of IL-1beta/IL-18 in phorbol myristate acetate-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	90-115	MALT1 paracaspase	Homo sapiens	31-36
21480396-11	2012	UVR or TPA-stimulated Stat3Ser727 phosphorylation accompanied interaction of PKCepsilon with ERK1/2 in intact mouse skin in vivo.	Tetradecanoylphorbol Acetate	7-10	protein kinase C, epsilon	Mus musculus	77-87
21480396-11	2012	UVR or TPA-stimulated Stat3Ser727 phosphorylation accompanied interaction of PKCepsilon with ERK1/2 in intact mouse skin in vivo.	Tetradecanoylphorbol Acetate	7-10	mitogen-activated protein kinase 3	Mus musculus	93-99
21480396-12	2012	Deletion of PKCepsilon in wild-type mice attenuated both TPA and UVR-induced expression of phosphoforms of ERK1/2 and Stat3Ser727.	Tetradecanoylphorbol Acetate	57-60	protein kinase C, epsilon	Mus musculus	12-22
21480396-13	2012	These results indicate that PKCepsilon integrates with ERK1/2 to mediate both TPA and UVR-induced epidermal Stat3Ser727 phosphorylation.	Tetradecanoylphorbol Acetate	78-81	protein kinase C, epsilon	Mus musculus	28-38
27054518-9	2016	Phorbol 12-myristate 13-acetate and phorbol 12,13-dibutyrate blocked the relaxation partially and so did the inhibition of heme oxygenase-1.	Tetradecanoylphorbol Acetate	0-31	heme oxygenase 1	Bos taurus	123-139
21480396-13	2012	These results indicate that PKCepsilon integrates with ERK1/2 to mediate both TPA and UVR-induced epidermal Stat3Ser727 phosphorylation.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 3	Mus musculus	55-61
21895511-8	2012	TNF-alpha treatment promoted NF-kappaB p65 binding to the M-CSF promoter in phorbol 12-myristate 13-acetate (PMA) treated U937 cells chronically infected with HIV-1 (U1 cells), but not in PMA treated uninfected U937 cells, suggesting that the presence of HIV-1 increases the NF-kappaB response.	Tetradecanoylphorbol Acetate	76-107	RELA proto-oncogene, NF-kB subunit	Homo sapiens	39-42
24054007-10	2013	Compared with the control group, the relative expression levels of FAK and p-FAK proteins in the PMA group (0.52 +- 0.06 and 0.51 +- 0.06) were significantly elevated, and those of the DMS group (0.20 +- 0.03 and 0.09 +- 0.02) were significantly decreased.	Tetradecanoylphorbol Acetate	97-100	protein tyrosine kinase 2	Homo sapiens	67-70
24054007-10	2013	Compared with the control group, the relative expression levels of FAK and p-FAK proteins in the PMA group (0.52 +- 0.06 and 0.51 +- 0.06) were significantly elevated, and those of the DMS group (0.20 +- 0.03 and 0.09 +- 0.02) were significantly decreased.	Tetradecanoylphorbol Acetate	97-100	protein tyrosine kinase 2	Homo sapiens	77-80
23430113-10	2013	Reconstitution of PKCdelta in patient-derived EBV-transformed B-cell lines partially restored phorbol-12-myristate-13-acetate-induced cell death.	Tetradecanoylphorbol Acetate	94-125	protein kinase C delta	Homo sapiens	18-26
22975515-7	2012	The bell-shaped curve of the AKR1C3 expression by 9,10-PQ resembled that caused by phorbol 12-myristate 13-acetate, a differentiation inducer.	Tetradecanoylphorbol Acetate	83-114	aldo-keto reductase family 1 member C3	Homo sapiens	29-35
26786102-5	2016	We show that androgen signaling suppresses TPA-induced c-Fos expression through repressing a PKC/MEK/ERK/ELK-1 signaling pathway.	Tetradecanoylphorbol Acetate	43-46	protein kinase C delta	Homo sapiens	93-96
23377348-4	2013	The results indicate that HSP70 interaction with MARCKS is enhanced after exposure of the cells to the protein kinase C activator/mucin secretagogue, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	150-181	myristoylated alanine rich protein kinase C substrate	Homo sapiens	49-55
23377348-4	2013	The results indicate that HSP70 interaction with MARCKS is enhanced after exposure of the cells to the protein kinase C activator/mucin secretagogue, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	150-181	LOC100508689	Homo sapiens	130-135
26840563-7	2016	50-75 kD were decreased in HepG2 treated with HGF or two other ROS generators, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and phenazine methosulfate.	Tetradecanoylphorbol Acetate	79-116	hepatocyte growth factor	Homo sapiens	46-49
23377348-4	2013	The results indicate that HSP70 interaction with MARCKS is enhanced after exposure of the cells to the protein kinase C activator/mucin secretagogue, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	183-186	myristoylated alanine rich protein kinase C substrate	Homo sapiens	49-55
23377348-4	2013	The results indicate that HSP70 interaction with MARCKS is enhanced after exposure of the cells to the protein kinase C activator/mucin secretagogue, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	183-186	LOC100508689	Homo sapiens	130-135
23377348-5	2013	Pretreatment of NHBEs with MAL3-101 attenuated in a concentration-dependent manner PMA-stimulated mucin secretion and interactions among HSP70, MARCKS, and CSP.	Tetradecanoylphorbol Acetate	83-86	LOC100508689	Homo sapiens	98-103
23377348-5	2013	Pretreatment of NHBEs with MAL3-101 attenuated in a concentration-dependent manner PMA-stimulated mucin secretion and interactions among HSP70, MARCKS, and CSP.	Tetradecanoylphorbol Acetate	83-86	myristoylated alanine rich protein kinase C substrate	Homo sapiens	144-150
21951556-4	2012	The expression of ULBP1 was not induced by inhibitors of nuclear factor-kappaB, phosphatidylinositol 3 kinase, and MAPK, but was induced by inhibitors of PKC, and the induction of ULBP1 expression with EGFR inhibitors was prevented by treatment with PMA in colon cancer cells.	Tetradecanoylphorbol Acetate	250-253	UL16 binding protein 1	Homo sapiens	18-23
21951556-4	2012	The expression of ULBP1 was not induced by inhibitors of nuclear factor-kappaB, phosphatidylinositol 3 kinase, and MAPK, but was induced by inhibitors of PKC, and the induction of ULBP1 expression with EGFR inhibitors was prevented by treatment with PMA in colon cancer cells.	Tetradecanoylphorbol Acetate	250-253	UL16 binding protein 1	Homo sapiens	180-185
23258984-6	2012	TGSs and individual GSs also significantly decreased MMP-2 and MMP-9 reporter gene activities in the presence of phorbol 12-myristate 13-acetate (PMA), the MMP inducer.	Tetradecanoylphorbol Acetate	113-144	matrix metallopeptidase 9	Mus musculus	63-68
23258984-6	2012	TGSs and individual GSs also significantly decreased MMP-2 and MMP-9 reporter gene activities in the presence of phorbol 12-myristate 13-acetate (PMA), the MMP inducer.	Tetradecanoylphorbol Acetate	146-149	matrix metallopeptidase 9	Mus musculus	63-68
26840563-7	2016	50-75 kD were decreased in HepG2 treated with HGF or two other ROS generators, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and phenazine methosulfate.	Tetradecanoylphorbol Acetate	118-121	hepatocyte growth factor	Homo sapiens	46-49
26929603-0	2016	Andrographolide suppresses thymic stromal lymphopoietin in phorbol myristate acetate/calcium ionophore A23187-activated mast cells and 2,4-dinitrofluorobenzene-induced atopic dermatitis-like mice model.	Tetradecanoylphorbol Acetate	59-84	thymic stromal lymphopoietin	Mus musculus	27-55
21947138-7	2012	In both cell lines, zymography demonstrated a band             corresponding to MMP-2 in normal cells and MMP-9 with phorbol 12-myristate 13-acetate             treatment.	Tetradecanoylphorbol Acetate	117-148	matrix metallopeptidase 2	Homo sapiens	80-85
23271308-6	2013	While for TPA dyes, the longer conjugate bridges generate the larger oscillator strength and light harvesting efficiency, and the TPAR1 and TPAR4 have larger free energy change for electron injection and dye regeneration.	Tetradecanoylphorbol Acetate	10-13	C-X-C motif chemokine ligand 12	Homo sapiens	130-135
23408313-4	2013	The application of PG significantly inhibited the nuclear translocation of p65, a subunit of nuclear factor-kappaB (NF-kappaB) and phosphorylation of p65 (Ser536) in TPA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	166-169	RELA proto-oncogene, NF-kB subunit	Homo sapiens	75-78
23408313-4	2013	The application of PG significantly inhibited the nuclear translocation of p65, a subunit of nuclear factor-kappaB (NF-kappaB) and phosphorylation of p65 (Ser536) in TPA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	166-169	RELA proto-oncogene, NF-kB subunit	Homo sapiens	150-153
23300872-6	2012	The amino acid sequence of CST1 exhibits structural features similar to those found in other serine proteases, including human tissue-type (tPA), urokinase (uPA), and vampire bat (DSPAalpha1) plasminogen activators.	Tetradecanoylphorbol Acetate	140-143	cystatin SN	Homo sapiens	27-31
26848699-5	2016	Although Snail family factors have been linked to inflammation via interactions with the cyclooxygenase-2 (COX-2) pathway, a pathway that also plays an important role in skin carcinogenesis, transient TPA induction of Slug and Snail appeared unrelated to COX-2 expression.	Tetradecanoylphorbol Acetate	201-204	prostaglandin-endoperoxide synthase 2	Mus musculus	107-112
26848699-5	2016	Although Snail family factors have been linked to inflammation via interactions with the cyclooxygenase-2 (COX-2) pathway, a pathway that also plays an important role in skin carcinogenesis, transient TPA induction of Slug and Snail appeared unrelated to COX-2 expression.	Tetradecanoylphorbol Acetate	201-204	prostaglandin-endoperoxide synthase 2	Mus musculus	255-260
26546672-7	2016	The present study uses MS-based methods to identify PKCdelta phosphorylation at Thr(50) and Ser(645) (in resting and PMA-treated cardiomyocytes) as well as Thr(37), Thr(38), Ser(130), Thr(164), Thr(211), Thr(215), Ser(218), Thr(295), Ser(299) and Thr(656) (as sites that increase with PMA).	Tetradecanoylphorbol Acetate	117-120	protein kinase C delta	Homo sapiens	52-60
22189182-10	2011	RESULTS: BrD1 remarkably suppressed TPA-induced vascular permeability and edema in skin.	Tetradecanoylphorbol Acetate	36-39	bromodomain containing 1	Mus musculus	9-13
22189182-11	2011	At the biochemical level, BrD1 inhibited TPA-induced expression of cyclooxygenase-2, inducible nitric oxide synthase and matrix metalloproteinase-9, the key indicators of cutaneous inflammation.	Tetradecanoylphorbol Acetate	41-44	bromodomain containing 1	Mus musculus	26-30
22189182-11	2011	At the biochemical level, BrD1 inhibited TPA-induced expression of cyclooxygenase-2, inducible nitric oxide synthase and matrix metalloproteinase-9, the key indicators of cutaneous inflammation.	Tetradecanoylphorbol Acetate	41-44	prostaglandin-endoperoxide synthase 2	Mus musculus	67-83
22189182-11	2011	At the biochemical level, BrD1 inhibited TPA-induced expression of cyclooxygenase-2, inducible nitric oxide synthase and matrix metalloproteinase-9, the key indicators of cutaneous inflammation.	Tetradecanoylphorbol Acetate	41-44	matrix metallopeptidase 9	Mus musculus	121-147
23452562-7	2013	Functional analyses revealed that splenic NKp46high NK cells produced much higher levels of Interferon-gamma and Tumor Necrosis Factor-alpha upon stimulation with cytokines or phorbol-12-myristate-13-acetate/Ionomycin compared to the other two subsets.	Tetradecanoylphorbol Acetate	176-207	interferon gamma	Sus scrofa	92-140
26796274-3	2016	When MCF-7 cells were treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) for up to 3 weeks, the effect of TPA on Wnt signaling pathway was dramatically different depending on the exposure time.	Tetradecanoylphorbol Acetate	35-71	Wnt family member 3A	Homo sapiens	118-121
23269677-3	2013	The studies herein demonstrate that the human meprin alpha transcript is bound and stabilized by Hu antigen R at baseline, and that treatment with the inflammatory stimulus phorbol 12-myristate 13-acetate downregulates meprin alpha expression by inducing tristetraprolin.	Tetradecanoylphorbol Acetate	173-204	ZFP36 ring finger protein	Homo sapiens	255-270
26796274-3	2016	When MCF-7 cells were treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) for up to 3 weeks, the effect of TPA on Wnt signaling pathway was dramatically different depending on the exposure time.	Tetradecanoylphorbol Acetate	73-76	Wnt family member 3A	Homo sapiens	118-121
26796274-3	2016	When MCF-7 cells were treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) for up to 3 weeks, the effect of TPA on Wnt signaling pathway was dramatically different depending on the exposure time.	Tetradecanoylphorbol Acetate	111-114	Wnt family member 3A	Homo sapiens	118-121
26796274-4	2016	The short term exposure (3 days) of MCF-7 cells to TPA exhibited significant induction of Wnt5a expression, along with the enhanced expression of PKC-alpha, to promote cell migration, which suggested that activation of noncanonical Wnt signaling pathway is associated with PKC-alpha.	Tetradecanoylphorbol Acetate	51-54	Wnt family member 3A	Homo sapiens	90-93
23002036-7	2013	Chromatin immunoprecipitation assays were used to identify a 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element (TRE-III) responsible for c-Jun-mediated transcriptional activation of Gipr.	Tetradecanoylphorbol Acetate	61-97	jun proto-oncogene	Mus musculus	147-152
26796274-5	2016	However, the chronic exposure (3 weeks) of cells to TPA completely suppressed Wnt5a expression and the expression of PKC-eta and PKC-delta, whereas the expression of Wnt3a and PKC-theta were up-regulated to activate the canonical Wnt signaling pathway.	Tetradecanoylphorbol Acetate	52-55	Wnt family member 3A	Homo sapiens	78-81
23002036-7	2013	Chromatin immunoprecipitation assays were used to identify a 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element (TRE-III) responsible for c-Jun-mediated transcriptional activation of Gipr.	Tetradecanoylphorbol Acetate	99-102	jun proto-oncogene	Mus musculus	147-152
23333628-9	2013	Quercetin also inhibited histamine- or PMA-induced phosphorylation of Tyr(311) of PKCdelta and translocation of PKCdelta to the Golgi.	Tetradecanoylphorbol Acetate	39-42	protein kinase C delta	Homo sapiens	82-90
26743816-10	2016	Pre-treatment of the osteoblasts with staurosporine prevented the increase in CCN2 expression by induced by LPA, and the activation of PKC by phorbol 12-myristate 13-acetate (PMA) enhanced CCN2 expression, indicating that the PKC pathway is involved in the LPA-induced increase in CCN2 expression.	Tetradecanoylphorbol Acetate	142-173	cellular communication network factor 2	Mus musculus	189-193
23333628-9	2013	Quercetin also inhibited histamine- or PMA-induced phosphorylation of Tyr(311) of PKCdelta and translocation of PKCdelta to the Golgi.	Tetradecanoylphorbol Acetate	39-42	protein kinase C delta	Homo sapiens	112-120
26743816-10	2016	Pre-treatment of the osteoblasts with staurosporine prevented the increase in CCN2 expression by induced by LPA, and the activation of PKC by phorbol 12-myristate 13-acetate (PMA) enhanced CCN2 expression, indicating that the PKC pathway is involved in the LPA-induced increase in CCN2 expression.	Tetradecanoylphorbol Acetate	142-173	cellular communication network factor 2	Mus musculus	189-193
26743816-10	2016	Pre-treatment of the osteoblasts with staurosporine prevented the increase in CCN2 expression by induced by LPA, and the activation of PKC by phorbol 12-myristate 13-acetate (PMA) enhanced CCN2 expression, indicating that the PKC pathway is involved in the LPA-induced increase in CCN2 expression.	Tetradecanoylphorbol Acetate	175-178	cellular communication network factor 2	Mus musculus	189-193
23513714-0	2013	Chemopreventive effect of sarcophine-diol on NOR-1-induced TPA-promoted skin carcinogenesis in female HOS:HR-1 mice.	Tetradecanoylphorbol Acetate	59-62	nuclear receptor subfamily 4, group A, member 3	Mus musculus	45-50
26743816-10	2016	Pre-treatment of the osteoblasts with staurosporine prevented the increase in CCN2 expression by induced by LPA, and the activation of PKC by phorbol 12-myristate 13-acetate (PMA) enhanced CCN2 expression, indicating that the PKC pathway is involved in the LPA-induced increase in CCN2 expression.	Tetradecanoylphorbol Acetate	175-178	cellular communication network factor 2	Mus musculus	189-193
26586620-5	2016	We investigated this issue by monitoring the effects of polyozellin on phorbol-12-myristate 13-acetate (PMA)-, tumor necrosis factor (TNF)-alpha-, interleukin (IL)-1beta-induced EPCR shedding in human umbilical vein endothelial cells (HUVECs), and cecal ligation and puncture (CLP)-mediated EPCR shedding in mice and underlying mechanism.	Tetradecanoylphorbol Acetate	71-102	protein C receptor	Homo sapiens	178-182
23216019-5	2013	Antigen receptor-induced inhibition of Ets-1 mRNA can be mimicked by phorbol myristate acetate (PMA) and/or ionomycin.	Tetradecanoylphorbol Acetate	69-94	E26 avian leukemia oncogene 1, 5' domain	Mus musculus	39-44
23216019-5	2013	Antigen receptor-induced inhibition of Ets-1 mRNA can be mimicked by phorbol myristate acetate (PMA) and/or ionomycin.	Tetradecanoylphorbol Acetate	96-99	E26 avian leukemia oncogene 1, 5' domain	Mus musculus	39-44
23216019-6	2013	PMA but not ionomycin-induced inhibition of Ets-1 expression is rescued by the inhibitors of protein kinase C and MEK.	Tetradecanoylphorbol Acetate	0-3	midkine	Mus musculus	114-117
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	41-72	ATP binding cassette subfamily C member 3	Homo sapiens	204-208
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	74-77	ATP binding cassette subfamily C member 3	Homo sapiens	204-208
26475020-5	2015	During phorbol myristate acetate (PMA)-activation of HDLECs, miR-132 is induced in a CREB-dependent manner and inhibition of miR-132 results in increased AGO2 expression.	Tetradecanoylphorbol Acetate	7-32	microRNA 132	Homo sapiens	61-68
23010891-7	2013	Injection of phorbol 12-myristate 13 acetate, an activator of PKC, before cardioplegic ischemia induced translocation of PKC-delta and -epsilon isoforms to membrane fraction, nuclear accumulation of Nrf2, and conferred cardioprotection similar to IPC.	Tetradecanoylphorbol Acetate	13-44	protein kinase C gamma type	Oryctolagus cuniculus	121-143
26475020-5	2015	During phorbol myristate acetate (PMA)-activation of HDLECs, miR-132 is induced in a CREB-dependent manner and inhibition of miR-132 results in increased AGO2 expression.	Tetradecanoylphorbol Acetate	7-32	microRNA 132	Homo sapiens	125-132
23383050-4	2013	We demonstrate simultaneous measurement of miR155 and CD69 in 12-O-tetradecanoylphorbol 13-acetate (PMA) and Ionomycin stimulated Jurkat cells.	Tetradecanoylphorbol Acetate	62-98	CD69 molecule	Homo sapiens	54-58
26475020-5	2015	During phorbol myristate acetate (PMA)-activation of HDLECs, miR-132 is induced in a CREB-dependent manner and inhibition of miR-132 results in increased AGO2 expression.	Tetradecanoylphorbol Acetate	34-37	microRNA 132	Homo sapiens	61-68
23383050-4	2013	We demonstrate simultaneous measurement of miR155 and CD69 in 12-O-tetradecanoylphorbol 13-acetate (PMA) and Ionomycin stimulated Jurkat cells.	Tetradecanoylphorbol Acetate	100-103	CD69 molecule	Homo sapiens	54-58
26475020-5	2015	During phorbol myristate acetate (PMA)-activation of HDLECs, miR-132 is induced in a CREB-dependent manner and inhibition of miR-132 results in increased AGO2 expression.	Tetradecanoylphorbol Acetate	34-37	microRNA 132	Homo sapiens	125-132
26404773-8	2015	In contrast, activation of the PKC system by phorbol 12-myristate 13-acetate (PMA) exerted inhibitory actions on TRPC6 and suppressed its expression.	Tetradecanoylphorbol Acetate	45-76	transient receptor potential cation channel subfamily C member 6	Homo sapiens	113-118
23216989-7	2012	In contrast, PMA-induced THP-1 differentiation toward monocytic cells expressed CD11b+, and CD14+, but not CD123, and revealed exclusively IL-12 expression while stimulated by dengue-2.	Tetradecanoylphorbol Acetate	13-16	CD14 molecule	Homo sapiens	92-96
23216989-7	2012	In contrast, PMA-induced THP-1 differentiation toward monocytic cells expressed CD11b+, and CD14+, but not CD123, and revealed exclusively IL-12 expression while stimulated by dengue-2.	Tetradecanoylphorbol Acetate	13-16	interleukin 3 receptor subunit alpha	Homo sapiens	107-112
26404773-8	2015	In contrast, activation of the PKC system by phorbol 12-myristate 13-acetate (PMA) exerted inhibitory actions on TRPC6 and suppressed its expression.	Tetradecanoylphorbol Acetate	78-81	transient receptor potential cation channel subfamily C member 6	Homo sapiens	113-118
26404773-9	2015	Importantly, PMA treatment markedly down-regulated the expression levels of PKCalpha, PKCbeta, and PKCeta reflecting their activation.	Tetradecanoylphorbol Acetate	13-16	protein kinase C beta	Homo sapiens	86-93
22986104-3	2012	TPA induced the expression of critical events of tumorigenesis like ornithine decarboxylase, cyclooxygenase-2, interleukin-6 and pSTAT3 in mouse skin after 5h of application, whereas expression of transglutaminase2 was decreased at this time point.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	93-109
26498639-11	2015	The levels of MMP-2, MMP-9, E-cad and integrin beta1 in the TPA-induced A549 cells changed markedly, compared with the untreated cells.	Tetradecanoylphorbol Acetate	60-63	matrix metallopeptidase 2	Homo sapiens	14-19
22842666-5	2012	Moreover, pterostilbene markedly suppressed TPA-induced activation of extracellular signal-regulated kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt, which are upstream of NFkappaB and activator protein 1 (AP-1).	Tetradecanoylphorbol Acetate	44-47	mitogen-activated protein kinase 3	Mus musculus	70-116
22842666-5	2012	Moreover, pterostilbene markedly suppressed TPA-induced activation of extracellular signal-regulated kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt, which are upstream of NFkappaB and activator protein 1 (AP-1).	Tetradecanoylphorbol Acetate	44-47	mitogen-activated protein kinase 14	Mus musculus	118-121
22842666-5	2012	Moreover, pterostilbene markedly suppressed TPA-induced activation of extracellular signal-regulated kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt, which are upstream of NFkappaB and activator protein 1 (AP-1).	Tetradecanoylphorbol Acetate	44-47	jun proto-oncogene	Mus musculus	278-297
22842666-5	2012	Moreover, pterostilbene markedly suppressed TPA-induced activation of extracellular signal-regulated kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt, which are upstream of NFkappaB and activator protein 1 (AP-1).	Tetradecanoylphorbol Acetate	44-47	jun proto-oncogene	Mus musculus	299-303
26608825-5	2015	In HT1080 cells, TSG101 depletion increased both baseline and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion through enhancing MMP-9 mRNA expression, but did not affect the expression or activation of MMP-2.	Tetradecanoylphorbol Acetate	95-98	matrix metallopeptidase 2	Homo sapiens	216-221
26486958-9	2015	Transcript destabilization by TTP was nullified upon cellular activation by TPA/A23187, an effect dependent on MEK1/2 activity.	Tetradecanoylphorbol Acetate	76-79	ZFP36 ring finger protein	Homo sapiens	30-33
22549474-10	2012	Patients with active lupus had higher nitrated T cell PKCdelta levels than did controls, which correlated directly with disease activity, and antinitrotyrosine immunoprecipitations demonstrated that nitrated PKCdelta, but not unmodified PKCdelta, was refractory to PMA-stimulated T(505)  phosphorylation, similar to PKCdelta in peroxynitrite-treated cells.	Tetradecanoylphorbol Acetate	265-268	protein kinase C delta	Homo sapiens	208-216
22549474-10	2012	Patients with active lupus had higher nitrated T cell PKCdelta levels than did controls, which correlated directly with disease activity, and antinitrotyrosine immunoprecipitations demonstrated that nitrated PKCdelta, but not unmodified PKCdelta, was refractory to PMA-stimulated T(505)  phosphorylation, similar to PKCdelta in peroxynitrite-treated cells.	Tetradecanoylphorbol Acetate	265-268	protein kinase C delta	Homo sapiens	208-216
22549474-10	2012	Patients with active lupus had higher nitrated T cell PKCdelta levels than did controls, which correlated directly with disease activity, and antinitrotyrosine immunoprecipitations demonstrated that nitrated PKCdelta, but not unmodified PKCdelta, was refractory to PMA-stimulated T(505)  phosphorylation, similar to PKCdelta in peroxynitrite-treated cells.	Tetradecanoylphorbol Acetate	265-268	protein kinase C delta	Homo sapiens	208-216
22623726-9	2012	Smurf2 depletion also counteracted the TPA-induced endocytosis and degradation of connexin43.	Tetradecanoylphorbol Acetate	39-42	gap junction protein alpha 1	Homo sapiens	82-92
26473723-3	2015	Phorbol myristate acetate markedly inhibited LPA1- and LPA3-mediated effect, whereas that mediated by LPA2 was only partially diminished; the actions of the phorbol ester were inhibited by bisindolylmaleimide I and by overnight incubation with the protein kinase C activator, which leads to down regulation of this protein kinase.	Tetradecanoylphorbol Acetate	0-25	lysophosphatidic acid receptor 3	Homo sapiens	55-59
22643241-3	2012	Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed.	Tetradecanoylphorbol Acetate	31-62	protein kinase C delta	Homo sapiens	17-20
22643241-3	2012	Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed.	Tetradecanoylphorbol Acetate	31-62	progesterone receptor	Homo sapiens	335-356
26438830-4	2015	In murine bone marrow-derived macrophages and murine embryonic fibroblasts stimulated with their cognate growth factors or with phorbol myristate acetate, activation of mTORC1 required an Akt-independent vesicular pathway of amino acid delivery into endolysosomes, mediated by the actin cytoskeleton.	Tetradecanoylphorbol Acetate	128-153	CREB regulated transcription coactivator 1	Mus musculus	169-175
22643241-3	2012	Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed.	Tetradecanoylphorbol Acetate	31-62	C-X-C motif chemokine ligand 12	Homo sapiens	361-367
22643241-3	2012	Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed.	Tetradecanoylphorbol Acetate	64-67	protein kinase C delta	Homo sapiens	17-20
22643241-3	2012	Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed.	Tetradecanoylphorbol Acetate	64-67	progesterone receptor	Homo sapiens	335-356
22643241-3	2012	Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed.	Tetradecanoylphorbol Acetate	64-67	C-X-C motif chemokine ligand 12	Homo sapiens	361-367
25979836-5	2015	PAK2 was activated by some pancreatic growth-factors [EGF, PDGF, bFGF], by secretagogues activating phospholipase-C (PLC) [CCK, carbachol, bombesin] and by post-receptor stimulants activating PKC [TPA], but not agents only mobilizing cellular calcium or increasing cyclic AMP.	Tetradecanoylphorbol Acetate	197-200	p21 (RAC1) activated kinase 2	Rattus norvegicus	0-4
22583821-10	2012	A 8-10-fold greater PMA-induced increase in CNP transcript in SMC than in HAEC suggests that smooth muscle cells could be selectively targeted for CNP up-regulation by PKC-alpha- and PKC-delta-activators.	Tetradecanoylphorbol Acetate	20-23	protein kinase C delta	Homo sapiens	183-192
26268522-11	2015	When phorbol 12-myristate 13-acetate (PMA)/Ionomycin was washed out from the cell culture after 6 h stimulation, Treg induction continued for at least 96 h of cell culture, contradicting the hypothesis that removal of the stimulus results in significant decrease of IFNgamma- and IFNgamma+ CD4+CD25+Foxp3+CD127- Treg due to loss of Foxp3 expression.	Tetradecanoylphorbol Acetate	5-36	forkhead box P3	Homo sapiens	299-304
22318307-3	2012	We found that D-limonene (50 and 100 mg/kg body weight) treatments to the mouse skin significantly reduced the TPA-induced (a) edema and hyperplasia (p &lt; 0.001); (b) expression of cyclooxygenase-2; (c) ornithine decarboxylase activity (p &lt; 0.001); and (d) [(3)H] thymidine incorporation into DNA (p &lt; 0.001).	Tetradecanoylphorbol Acetate	111-114	prostaglandin-endoperoxide synthase 2	Mus musculus	183-199
22562304-5	2012	Moreover, TPA-induced Ser(16) Pin1 phosphorylation as well as RSK2 phosphorylation was considerably profound in RSK(+/+) MEFs but not in RSK(-/-) MEFs.	Tetradecanoylphorbol Acetate	10-13	ribosomal protein S6 kinase A3	Homo sapiens	112-115
26268522-11	2015	When phorbol 12-myristate 13-acetate (PMA)/Ionomycin was washed out from the cell culture after 6 h stimulation, Treg induction continued for at least 96 h of cell culture, contradicting the hypothesis that removal of the stimulus results in significant decrease of IFNgamma- and IFNgamma+ CD4+CD25+Foxp3+CD127- Treg due to loss of Foxp3 expression.	Tetradecanoylphorbol Acetate	5-36	forkhead box P3	Homo sapiens	332-337
26268522-11	2015	When phorbol 12-myristate 13-acetate (PMA)/Ionomycin was washed out from the cell culture after 6 h stimulation, Treg induction continued for at least 96 h of cell culture, contradicting the hypothesis that removal of the stimulus results in significant decrease of IFNgamma- and IFNgamma+ CD4+CD25+Foxp3+CD127- Treg due to loss of Foxp3 expression.	Tetradecanoylphorbol Acetate	38-41	forkhead box P3	Homo sapiens	299-304
26268522-11	2015	When phorbol 12-myristate 13-acetate (PMA)/Ionomycin was washed out from the cell culture after 6 h stimulation, Treg induction continued for at least 96 h of cell culture, contradicting the hypothesis that removal of the stimulus results in significant decrease of IFNgamma- and IFNgamma+ CD4+CD25+Foxp3+CD127- Treg due to loss of Foxp3 expression.	Tetradecanoylphorbol Acetate	38-41	forkhead box P3	Homo sapiens	332-337
21989206-8	2011	KEY FINDINGS: Transduced PEP-1-CypA protein markedly inhibited lipopolysaccharide- and 12-O-tetradecanoyl phorbol-13-acetate-induced expression levels of COX-2 as well as pro-inflammatory cytokine levels in vitro and in vivo.	Tetradecanoylphorbol Acetate	87-124	prostaglandin-endoperoxide synthase 2	Mus musculus	154-159
27774419-3	2016	The in vivo anti-inflammatory activity of selected samples showing promising COX-2 inhibition was assessed using carrageenan and Phorbol Myristate Acetate (PMA) induced mice edema animal model.	Tetradecanoylphorbol Acetate	129-154	cytochrome c oxidase II, mitochondrial	Mus musculus	77-82
21864583-3	2011	In this study, we examined the functional roles of mouse Zac1 (mZac1) in HeLa cells treated with 12-O-tetradecanoylphorbol-13-acetate (PMA), a potent Activator protein 1 (AP-1) activator.	Tetradecanoylphorbol Acetate	97-133	pleiomorphic adenoma gene-like 1	Mus musculus	57-61
21864583-3	2011	In this study, we examined the functional roles of mouse Zac1 (mZac1) in HeLa cells treated with 12-O-tetradecanoylphorbol-13-acetate (PMA), a potent Activator protein 1 (AP-1) activator.	Tetradecanoylphorbol Acetate	97-133	pleiomorphic adenoma gene-like 1	Mus musculus	63-68
22562304-7	2012	Overall, these results indicate that Pin1 plays a critical role in TPA-induced tumorigenesis plausibly via physical interaction with RSK2 and reciprocal phosphorylation, therefore suggesting a potential therapeutic target for cancer treatment.	Tetradecanoylphorbol Acetate	67-70	ribosomal protein S6 kinase A3	Homo sapiens	133-137
22597534-7	2012	Deletion and mutation analysis of human LOX-1 promoter-luciferase constructs transfected into HAEC with an androgen receptor (AR) expression plasmid revealed that the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (TRE; nucleotides -60/-53) contributed to the inhibitory effects of DHT on TNFalpha-induced LOX-1 expression.	Tetradecanoylphorbol Acetate	167-203	oxidized low density lipoprotein receptor 1	Homo sapiens	40-45
22597534-7	2012	Deletion and mutation analysis of human LOX-1 promoter-luciferase constructs transfected into HAEC with an androgen receptor (AR) expression plasmid revealed that the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (TRE; nucleotides -60/-53) contributed to the inhibitory effects of DHT on TNFalpha-induced LOX-1 expression.	Tetradecanoylphorbol Acetate	167-203	oxidized low density lipoprotein receptor 1	Homo sapiens	319-324
22597534-8	2012	Chromatin immunoprecipitation (ChIP) and re-ChIP assays revealed that TNFalpha- and TPA-dependent enrichment of p65 and phosphorylated c-Jun in the TRE chromatin region was inhibited by DHT-AR.	Tetradecanoylphorbol Acetate	84-87	transcription factor Jun	Oryctolagus cuniculus	135-140
21864583-3	2011	In this study, we examined the functional roles of mouse Zac1 (mZac1) in HeLa cells treated with 12-O-tetradecanoylphorbol-13-acetate (PMA), a potent Activator protein 1 (AP-1) activator.	Tetradecanoylphorbol Acetate	135-138	pleiomorphic adenoma gene-like 1	Mus musculus	57-61
21864583-3	2011	In this study, we examined the functional roles of mouse Zac1 (mZac1) in HeLa cells treated with 12-O-tetradecanoylphorbol-13-acetate (PMA), a potent Activator protein 1 (AP-1) activator.	Tetradecanoylphorbol Acetate	135-138	pleiomorphic adenoma gene-like 1	Mus musculus	63-68
27774419-3	2016	The in vivo anti-inflammatory activity of selected samples showing promising COX-2 inhibition was assessed using carrageenan and Phorbol Myristate Acetate (PMA) induced mice edema animal model.	Tetradecanoylphorbol Acetate	156-159	cytochrome c oxidase II, mitochondrial	Mus musculus	77-82
22542552-0	2012	Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-kappaB, C/EBP and AP-1 signaling pathways in murine macrophages.	Tetradecanoylphorbol Acetate	18-21	prostaglandin-endoperoxide synthase 2	Mus musculus	30-46
22542552-0	2012	Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-kappaB, C/EBP and AP-1 signaling pathways in murine macrophages.	Tetradecanoylphorbol Acetate	18-21	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	92-97
26116564-8	2015	Treatment of HT29 and Caco-2 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced an invasive phenotype response along with corresponding increases in ROS production and NOX2 and MMP-7 expression as well as reduced AMPK phosphorylation, which resemble basal conditions of highly invasive human colon cancer cells (SW620 and HCT116).	Tetradecanoylphorbol Acetate	40-76	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	224-228
22542552-0	2012	Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-kappaB, C/EBP and AP-1 signaling pathways in murine macrophages.	Tetradecanoylphorbol Acetate	18-21	jun proto-oncogene	Mus musculus	102-106
22542552-3	2012	In the present study, we investigated the inhibitory effects of piperine on phorbol 12-myristate 13-acetate (PMA)-induced cyclooxygenase-2 (COX-2) gene expression and analyzed the molecular mechanism of its activity in murine RAW 264.7 macrophages.	Tetradecanoylphorbol Acetate	76-107	prostaglandin-endoperoxide synthase 2	Mus musculus	122-138
22232712-0	2011	The Effect of Doxycycline on PMA-Induced MUC5B Expression via MMP-9 and p38 in NCI-H292 Cells.	Tetradecanoylphorbol Acetate	29-32	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	41-46
26116564-8	2015	Treatment of HT29 and Caco-2 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced an invasive phenotype response along with corresponding increases in ROS production and NOX2 and MMP-7 expression as well as reduced AMPK phosphorylation, which resemble basal conditions of highly invasive human colon cancer cells (SW620 and HCT116).	Tetradecanoylphorbol Acetate	78-81	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	224-228
22232712-4	2011	Phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, is known to stimulate the expression of MMP and mucin genes in the airway and intestinal epithelial cells.	Tetradecanoylphorbol Acetate	0-31	LOC100508689	Homo sapiens	117-122
22232712-4	2011	Phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, is known to stimulate the expression of MMP and mucin genes in the airway and intestinal epithelial cells.	Tetradecanoylphorbol Acetate	33-36	LOC100508689	Homo sapiens	117-122
22232712-5	2011	Therefore, the effects and signal pathways of doxycycline on PMA-induced MUC5B expression dependent MMP-9 in human airway epithelial cells were investigated.	Tetradecanoylphorbol Acetate	61-64	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	73-78
22232712-9	2011	Doxycycline inhibited PMA-induced MUC5B expression, and PMA-induced MMP-9 mRNA expression and protein activity.	Tetradecanoylphorbol Acetate	22-25	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	34-39
22542552-3	2012	In the present study, we investigated the inhibitory effects of piperine on phorbol 12-myristate 13-acetate (PMA)-induced cyclooxygenase-2 (COX-2) gene expression and analyzed the molecular mechanism of its activity in murine RAW 264.7 macrophages.	Tetradecanoylphorbol Acetate	76-107	prostaglandin-endoperoxide synthase 2	Mus musculus	140-145
22542552-3	2012	In the present study, we investigated the inhibitory effects of piperine on phorbol 12-myristate 13-acetate (PMA)-induced cyclooxygenase-2 (COX-2) gene expression and analyzed the molecular mechanism of its activity in murine RAW 264.7 macrophages.	Tetradecanoylphorbol Acetate	109-112	prostaglandin-endoperoxide synthase 2	Mus musculus	122-138
22542552-3	2012	In the present study, we investigated the inhibitory effects of piperine on phorbol 12-myristate 13-acetate (PMA)-induced cyclooxygenase-2 (COX-2) gene expression and analyzed the molecular mechanism of its activity in murine RAW 264.7 macrophages.	Tetradecanoylphorbol Acetate	109-112	prostaglandin-endoperoxide synthase 2	Mus musculus	140-145
22542552-4	2012	Piperine dose-dependently decreased PMA-induced COX-2 expression and PGE(2) production, as well as COX-2 promoter-driven luciferase activity.	Tetradecanoylphorbol Acetate	36-39	prostaglandin-endoperoxide synthase 2	Mus musculus	48-53
22232712-11	2011	CONCLUSION: The results of this study suggest that doxycycline inhibited PMA-induced MUC5B mRNA expression and protein production through the MMP-9 and p38 pathways in human NCI-H292 airway epithelial cells.	Tetradecanoylphorbol Acetate	73-76	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	85-90
26116564-12	2015	TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors.	Tetradecanoylphorbol Acetate	0-3	neutrophil cytosolic factor 2	Homo sapiens	189-196
26116564-12	2015	TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors.	Tetradecanoylphorbol Acetate	126-129	neutrophil cytosolic factor 2	Homo sapiens	189-196
26137162-7	2015	It has been established that signal transduction pathways and cytokines, including those activated by phorbol 12-myristate 13-acetate (PMA), regulate the expression of MMPs.	Tetradecanoylphorbol Acetate	102-133	matrix metallopeptidase 2	Homo sapiens	168-172
21890374-2	2011	In T-cells, IRF-4 expression is induced by T-cell receptor (TCR) cross-linking or treatment with phorbol-12-myristate-13-acetate (PMA)/Ionomycin, and IRF-4 is thought to be a critical factor for various functions of T-cells.	Tetradecanoylphorbol Acetate	97-128	interferon regulatory factor 4	Homo sapiens	12-17
21890374-2	2011	In T-cells, IRF-4 expression is induced by T-cell receptor (TCR) cross-linking or treatment with phorbol-12-myristate-13-acetate (PMA)/Ionomycin, and IRF-4 is thought to be a critical factor for various functions of T-cells.	Tetradecanoylphorbol Acetate	130-133	interferon regulatory factor 4	Homo sapiens	12-17
21964610-7	2011	Histopathological findings of tumors found in PAT/TPA treated mice showed that these tumors were of squamous cell carcinoma type and similar to those found in the positive control group (DMBA/TPA) along with significant increase of lipid peroxidation and decrease in free sulfydryls, catalase, superoxide dismutase and glutathione reductase activities.	Tetradecanoylphorbol Acetate	50-53	glutathione reductase	Mus musculus	319-340
22732221-3	2012	Also, application of Tat-ANX1 protein significantly inhibited nuclear translocation of nuclear factor-kappa B (NF-kappa B) and phosphorylation of p38 and extracellular signalregulated kinase (ERK) mitogen-activated protein kinase (MAPK) in TPA-treated mice ears.	Tetradecanoylphorbol Acetate	240-243	annexin A1	Mus musculus	25-29
22732221-4	2012	The results indicate that Tat-ANX1 protein inhibits the inflammatory response by blocking NF-kappa B and MAPK activation in TPA-induced mice ears.	Tetradecanoylphorbol Acetate	124-127	annexin A1	Mus musculus	30-34
26137162-7	2015	It has been established that signal transduction pathways and cytokines, including those activated by phorbol 12-myristate 13-acetate (PMA), regulate the expression of MMPs.	Tetradecanoylphorbol Acetate	135-138	matrix metallopeptidase 2	Homo sapiens	168-172
26137162-8	2015	The aim of the present study was to analyze the expression patterns of MMP-2, MMP-9 and MMP-9 dimer in normal human cells from a number of tissues treated with PMA.	Tetradecanoylphorbol Acetate	160-163	matrix metallopeptidase 2	Homo sapiens	71-76
22426323-4	2012	A PKC inhibitory study indicated that PMA-induced stimulation of MCT4 expression can be mediated through a novel PKC isoform, especially PKCdelta.	Tetradecanoylphorbol Acetate	38-41	protein kinase C delta	Homo sapiens	2-5
25677823-9	2015	Indeed, QRFP-43 attenuated phorbol 12-myristate 13-acetate-induced lipolysis and ISO-induced extracellular signal-regulated and Src kinases by 28, 37 and 48%, respectively.	Tetradecanoylphorbol Acetate	27-58	pyroglutamylated RFamide peptide	Homo sapiens	8-12
22426323-4	2012	A PKC inhibitory study indicated that PMA-induced stimulation of MCT4 expression can be mediated through a novel PKC isoform, especially PKCdelta.	Tetradecanoylphorbol Acetate	38-41	protein kinase C delta	Homo sapiens	113-116
22426323-4	2012	A PKC inhibitory study indicated that PMA-induced stimulation of MCT4 expression can be mediated through a novel PKC isoform, especially PKCdelta.	Tetradecanoylphorbol Acetate	38-41	protein kinase C delta	Homo sapiens	137-145
22311708-1	2012	SOCS-3 gene induction by cAMP-elevating agents or the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), in primary HUVECs was found to require PKCeta- and PKCepsilon-dependent extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	88-119	suppressor of cytokine signaling 3	Homo sapiens	0-6
22311708-1	2012	SOCS-3 gene induction by cAMP-elevating agents or the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), in primary HUVECs was found to require PKCeta- and PKCepsilon-dependent extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	121-124	suppressor of cytokine signaling 3	Homo sapiens	0-6
22403260-4	2012	CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment.	Tetradecanoylphorbol Acetate	70-95	integrin subunit alpha L	Homo sapiens	15-20
21784060-3	2011	In this study, we show that p67phox is constitutively phosphorylated in resting human neutrophils and that neutrophil stimulation with PMA further enhanced this phosphorylation.	Tetradecanoylphorbol Acetate	135-138	neutrophil cytosolic factor 2	Homo sapiens	28-35
21730054-16	2011	These results suggest the involvement of the PKCdelta/ERK/poly(ADP-ribose) polymerase-1 signaling pathway in histamine- or PMA-induced up-regulation of H1R gene expression in HeLa cells.	Tetradecanoylphorbol Acetate	123-126	protein kinase C delta	Homo sapiens	45-53
25725289-6	2015	Direct activation of PKC with PMA or indirect activation with the adenosine A1 receptor agonist 2-chloro-N(6)-cyclopentyladenosine (CCPA) led to significant increases in [(3)H]NBMPR binding and [(3)H]2-chloroadenosine uptake in WT-hENT1 transfected cells.	Tetradecanoylphorbol Acetate	30-33	protein kinase C delta	Homo sapiens	21-24
21673231-8	2011	In addition, TPA treatment also induced PKM2 whereas PKM1 expression was suppressed in mouse skin epidermal tissues in vivo.	Tetradecanoylphorbol Acetate	13-16	pyruvate kinase, muscle	Mus musculus	40-44
21804018-6	2011	In PKCdelta wild-type overexpressing THP1 cells, IRAK1 kinase activity and IL-1beta production were significantly augmented, whereas recombinant inactive PKCdelta and PKCdelta small interfering RNA significantly inhibited basal and PMA-induced IRAK1 activation and IL-1beta production.	Tetradecanoylphorbol Acetate	232-235	protein kinase C delta	Homo sapiens	154-162
21804018-6	2011	In PKCdelta wild-type overexpressing THP1 cells, IRAK1 kinase activity and IL-1beta production were significantly augmented, whereas recombinant inactive PKCdelta and PKCdelta small interfering RNA significantly inhibited basal and PMA-induced IRAK1 activation and IL-1beta production.	Tetradecanoylphorbol Acetate	232-235	protein kinase C delta	Homo sapiens	154-162
21804018-8	2011	IRAK1/4 inhibitors, their small interfering RNAs, and JNK inhibitor also attenuated PMA-induced IL-1beta production.	Tetradecanoylphorbol Acetate	84-87	interleukin 1 receptor associated kinase 1	Homo sapiens	0-5
22403260-4	2012	CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment.	Tetradecanoylphorbol Acetate	97-100	integrin subunit alpha L	Homo sapiens	15-20
22389501-6	2012	Phorbol myristate acetate, a known stimulator of NF-kappaB, increased the levels of GRK5 in myocytes whereas treatment of cells with N-acetyl cysteine, a known inhibitor of NF-kappaB, or with SC 514, an inhibitor of IkappaB kinase 2 decreased GRK5.	Tetradecanoylphorbol Acetate	0-25	G protein-coupled receptor kinase 5	Mus musculus	84-88
22389501-6	2012	Phorbol myristate acetate, a known stimulator of NF-kappaB, increased the levels of GRK5 in myocytes whereas treatment of cells with N-acetyl cysteine, a known inhibitor of NF-kappaB, or with SC 514, an inhibitor of IkappaB kinase 2 decreased GRK5.	Tetradecanoylphorbol Acetate	0-25	G protein-coupled receptor kinase 5	Mus musculus	243-247
21526343-0	2011	SP1 suppresses phorbol 12-myristate 13-acetate induced up-regulation of human regucalcin expression in liver cancer cells.	Tetradecanoylphorbol Acetate	15-46	regucalcin	Homo sapiens	78-88
25725289-7	2015	The PKC inhibitor Go6983 blocked these effects of both PMA and CCPA, and the CCPA-mediated increase was also blocked by the A1 adenosine receptor antagonist DPCPX.	Tetradecanoylphorbol Acetate	55-58	protein kinase C delta	Homo sapiens	4-7
25725289-10	2015	Immunocytochemical analysis and cell surface biotinylation assays showed that activation of PKC with PMA, but not CCPA, led to a significant increase in the plasma membrane localization of hENT1.	Tetradecanoylphorbol Acetate	101-104	protein kinase C delta	Homo sapiens	92-95
25725289-10	2015	Immunocytochemical analysis and cell surface biotinylation assays showed that activation of PKC with PMA, but not CCPA, led to a significant increase in the plasma membrane localization of hENT1.	Tetradecanoylphorbol Acetate	101-104	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	189-194
21659537-6	2011	Previous work indicated that mTORC1 activation by the phorbol ester PMA (phorbol 12-myristate 13-acetate) depends upon PKCs and may involve MEK.	Tetradecanoylphorbol Acetate	73-104	CREB regulated transcription coactivator 1	Mus musculus	29-35
25912851-9	2015	alpha-Asarone increased the expression levels of MMP-2 and MMP-9 stimulated by phenazine methosulfate (PMS) and phorbol 12-myristate 13-acetate (PMA) in HT1080.	Tetradecanoylphorbol Acetate	112-143	matrix metallopeptidase 2	Homo sapiens	49-54
21665893-9	2011	In summary, our data indicate that PKD1 is activated and downregulated by PMA through a PKC-dependent ubiquitin-proteasome degradation pathway, and the activation of PKD1 or PKD2 counteracts PMA-induced apoptosis by promoting downstream ERK1/2 and NF-kappaB activities in LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	74-77	protein kinase C delta	Homo sapiens	88-91
21381080-6	2011	The upregulation of Cldn18 by TPA in human pancreatic cancer cell lines was prevented by inhibitors of PKCdelta, PKCepsilon, and PKCalpha, whereas the upregulation of Cldn18 by TPA in hTERT-HPDE cells was prevented by inhibitors of PKCdelta, PKCtheta, and PKCalpha.	Tetradecanoylphorbol Acetate	177-180	claudin 18	Homo sapiens	167-173
21381080-7	2011	Furthermore, a CpG island was identified within the coding sequence of the Cldn18 gene and treatment with the demethylating agent 5-azadeoxycytidine enhanced upregulation of Cldn18 by TPA in HPAF-II and HPAC, but not hTERT-HPDE cells.	Tetradecanoylphorbol Acetate	184-187	claudin 18	Homo sapiens	75-81
21381080-7	2011	Furthermore, a CpG island was identified within the coding sequence of the Cldn18 gene and treatment with the demethylating agent 5-azadeoxycytidine enhanced upregulation of Cldn18 by TPA in HPAF-II and HPAC, but not hTERT-HPDE cells.	Tetradecanoylphorbol Acetate	184-187	claudin 18	Homo sapiens	174-180
22482411-7	2012	RT-PCR, Western blot and Dot blot were performed to detect the expression of syndecan-1 before and after stimulation of phorbol 12-myristate 13-acetate (PMA) for 15 min.	Tetradecanoylphorbol Acetate	120-151	syndecan 1	Mus musculus	77-87
22482411-7	2012	RT-PCR, Western blot and Dot blot were performed to detect the expression of syndecan-1 before and after stimulation of phorbol 12-myristate 13-acetate (PMA) for 15 min.	Tetradecanoylphorbol Acetate	153-156	syndecan 1	Mus musculus	77-87
25912851-9	2015	alpha-Asarone increased the expression levels of MMP-2 and MMP-9 stimulated by phenazine methosulfate (PMS) and phorbol 12-myristate 13-acetate (PMA) in HT1080.	Tetradecanoylphorbol Acetate	145-148	matrix metallopeptidase 2	Homo sapiens	49-54
25652588-4	2015	We show here that activation or overexpression of constitutively active merlin or downregulation of ERMs inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced [as well as serum, hepatocyte growth factor (HGF), or platelet-derived growth factor (PDGF)] CD44 cleavage by the metalloprotease ADAM10, whereas overexpressed ERM proteins promoted cleavage.	Tetradecanoylphorbol Acetate	115-151	ADAM metallopeptidase domain 10	Homo sapiens	296-302
24213313-11	2012	MMP-2 and MMP-9 activities were further modulated by phorbol 12-myristate 13-acetate (PMA) induction and inhibited by NM.	Tetradecanoylphorbol Acetate	53-84	matrix metallopeptidase 2	Homo sapiens	0-5
24213313-11	2012	MMP-2 and MMP-9 activities were further modulated by phorbol 12-myristate 13-acetate (PMA) induction and inhibited by NM.	Tetradecanoylphorbol Acetate	86-89	matrix metallopeptidase 2	Homo sapiens	0-5
21895511-8	2012	TNF-alpha treatment promoted NF-kappaB p65 binding to the M-CSF promoter in phorbol 12-myristate 13-acetate (PMA) treated U937 cells chronically infected with HIV-1 (U1 cells), but not in PMA treated uninfected U937 cells, suggesting that the presence of HIV-1 increases the NF-kappaB response.	Tetradecanoylphorbol Acetate	109-112	RELA proto-oncogene, NF-kB subunit	Homo sapiens	39-42
21045076-7	2011	Differentiated HL60 cells were stimulated with phorbol-12-myristate-7-acetate (PMA) after inhibition of SOD2 by small interfering RNA followed by respiratory burst assessment using flow cytometry.	Tetradecanoylphorbol Acetate	79-82	superoxide dismutase 2	Homo sapiens	104-108
21045076-10	2011	Inhibition of SOD2 reduced the PMA-induced respiratory burst and IL1A, IL-1R1, IL-1R2 and IL8RA gene expression in neutrophil-differentiated HL60 cells.	Tetradecanoylphorbol Acetate	31-34	superoxide dismutase 2	Homo sapiens	14-18
21045076-10	2011	Inhibition of SOD2 reduced the PMA-induced respiratory burst and IL1A, IL-1R1, IL-1R2 and IL8RA gene expression in neutrophil-differentiated HL60 cells.	Tetradecanoylphorbol Acetate	31-34	interleukin 1 receptor type 2	Homo sapiens	79-85
25652588-4	2015	We show here that activation or overexpression of constitutively active merlin or downregulation of ERMs inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced [as well as serum, hepatocyte growth factor (HGF), or platelet-derived growth factor (PDGF)] CD44 cleavage by the metalloprotease ADAM10, whereas overexpressed ERM proteins promoted cleavage.	Tetradecanoylphorbol Acetate	153-156	hepatocyte growth factor	Homo sapiens	185-209
25652588-4	2015	We show here that activation or overexpression of constitutively active merlin or downregulation of ERMs inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced [as well as serum, hepatocyte growth factor (HGF), or platelet-derived growth factor (PDGF)] CD44 cleavage by the metalloprotease ADAM10, whereas overexpressed ERM proteins promoted cleavage.	Tetradecanoylphorbol Acetate	153-156	hepatocyte growth factor	Homo sapiens	211-214
21268127-10	2011	While TPA highly induced COX-2 in WT mice, COX-2 expression in the BK5.EP1 mice did not change after TPA treatment; PGE(2) levels were likewise affected.	Tetradecanoylphorbol Acetate	6-9	prostaglandin-endoperoxide synthase 2	Mus musculus	25-30
22075471-6	2012	The fundamental subunits of membrane CYBB and cytosolic NCF2 were markedly upregulated after phorbol-12-myristate-13-acetate (PMA) treatment, as detected by quantitative real-time PCR, Western blotting, and immunohistochemistry.	Tetradecanoylphorbol Acetate	93-124	cytochrome b-245, beta polypeptide	Mus musculus	37-41
22075471-6	2012	The fundamental subunits of membrane CYBB and cytosolic NCF2 were markedly upregulated after phorbol-12-myristate-13-acetate (PMA) treatment, as detected by quantitative real-time PCR, Western blotting, and immunohistochemistry.	Tetradecanoylphorbol Acetate	126-129	cytochrome b-245, beta polypeptide	Mus musculus	37-41
21539301-5	2011	Compounds 1-8 were found to rescue Pdcd4 from TPA-induced degradation with EC50 concentrations that ranged from 1.3 to 4.9 muM.	Tetradecanoylphorbol Acetate	46-49	programmed cell death 4	Homo sapiens	35-40
25652588-4	2015	We show here that activation or overexpression of constitutively active merlin or downregulation of ERMs inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced [as well as serum, hepatocyte growth factor (HGF), or platelet-derived growth factor (PDGF)] CD44 cleavage by the metalloprotease ADAM10, whereas overexpressed ERM proteins promoted cleavage.	Tetradecanoylphorbol Acetate	153-156	ADAM metallopeptidase domain 10	Homo sapiens	296-302
25908095-6	2015	Conversely, MAPK/p38 inactivation or REGgamma deletion prevents the increase of cyclinD1 and c-Myc by TPA.	Tetradecanoylphorbol Acetate	102-105	cyclin D1	Homo sapiens	80-88
25514083-5	2015	Silencing or inhibition of PKCalpha and PKCdelta blocked PR phosphorylation and degradation induced by TPA.	Tetradecanoylphorbol Acetate	103-106	protein kinase C delta	Homo sapiens	40-48
25668518-5	2015	PMA, a pharmacologic NADPH oxidase activator, induced ER stress in dHL60 cells as monitored by IRE-1 and PERK pathway activation, and this was independent of calcium signaling.	Tetradecanoylphorbol Acetate	0-3	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	95-100
21438497-4	2011	12-O-Tetradecanolylphorbol-13-acetate (TPA) was applied to the ears of CD-1 mice to induce inflammation (edema), which was accompanied by increases in a series of biomarkers.	Tetradecanoylphorbol Acetate	39-42	CD1d1 molecule	Rattus norvegicus	71-75
25698902-4	2015	Furthermore, the results of gelatin zymography and reverse transcriptase polymerase chain reaction (RT-PCR) assays showed that galangin reduced the TPA-induced enzyme activity of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in HepG2 cells; moreover, the messenger RNA level was downregulated.	Tetradecanoylphorbol Acetate	148-151	matrix metallopeptidase 2	Homo sapiens	179-205
21454668-6	2011	MMP-9 transcription was decreased in phorbol 12-myristate 13-acetate-stimulated THP-1 macrophages to an extent similar to that induced by the peroxisome proliferator-activated receptor-gamma agonist Rosiglitazone.	Tetradecanoylphorbol Acetate	37-68	matrix metallopeptidase 9	Mus musculus	0-5
25698902-4	2015	Furthermore, the results of gelatin zymography and reverse transcriptase polymerase chain reaction (RT-PCR) assays showed that galangin reduced the TPA-induced enzyme activity of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in HepG2 cells; moreover, the messenger RNA level was downregulated.	Tetradecanoylphorbol Acetate	148-151	matrix metallopeptidase 2	Homo sapiens	207-212
25698902-5	2015	We also observed through a Western blotting assay that galangin strongly inhibited the TPA-induced protein expressions of protein kinase Calpha (PKCalpha), protein kinase Cdelta (PKCdelta), phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2), the phospho-inhibitor of kappaBalpha (phospho-IkappaBalpha), c-Fos, c-Jun, and nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	87-90	protein kinase C delta	Homo sapiens	156-177
25698902-5	2015	We also observed through a Western blotting assay that galangin strongly inhibited the TPA-induced protein expressions of protein kinase Calpha (PKCalpha), protein kinase Cdelta (PKCdelta), phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2), the phospho-inhibitor of kappaBalpha (phospho-IkappaBalpha), c-Fos, c-Jun, and nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	87-90	protein kinase C delta	Homo sapiens	179-187
21499124-5	2011	Treatment with phorbol 12-myristate 13-acetate restored the EGFR inhibitor-induced ULBP1 transcription.	Tetradecanoylphorbol Acetate	15-46	UL16 binding protein 1	Homo sapiens	83-88
26078803-4	2015	Moreover, exposure of human monocytic THP-1 cells differentiated with phorbol 12-myristate 13-acetate to 10 muM HNE, and to light density lipoprotein modified with HNE (HNE-LDL) or by copper-catalyzed oxidation (oxLDL), but not to native LDL, stimulated the formation of HNE adducts with HSP60, as detected by immunoprecipitation and western blot, well over basal levels.	Tetradecanoylphorbol Acetate	70-101	elastase, neutrophil expressed	Homo sapiens	112-115
21499124-6	2011	Binding activity to ULBP1 promoter region of AP-2alpha, which suggested as suppressor of expression of ULBP1, was decreased by treatment with EGFR inhibitors, and restored by pretreatment with phorbol 12-myristate 13-acetate in A549 and SW-900.	Tetradecanoylphorbol Acetate	193-224	UL16 binding protein 1	Homo sapiens	20-25
21089054-7	2011	Further, we found that acteoside decreased the PMA-induced influx of Ca(2+) and repressed PMA-induced calmodulin-dependent protein kinase (CaMK) phosphorylation.	Tetradecanoylphorbol Acetate	90-93	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	139-143
21089054-9	2011	CONCLUSION: Acteoside inhibited PMA-induced invasion and migration of human fibrosarcoma cells via Ca(2+) -dependent CaMK/ERK and JNK/NF-kappaB-signaling pathways.	Tetradecanoylphorbol Acetate	32-35	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	117-121
25489104-6	2014	The most up-regulated gene on DUSP5 loss encodes SerpinB2, an inhibitor of extracellular urokinase plasminogen activator and deletion of DUSP5 acts synergistically with mutant HRas(Q61L) and TPA to activate ERK-dependent SerpinB2 expression at the transcriptional level.	Tetradecanoylphorbol Acetate	191-194	serine (or cysteine) peptidase inhibitor, clade B, member 2	Mus musculus	49-57
25489104-7	2014	SerpinB2 has previously been implicated as a mediator of DMBA/TPA-induced skin carcinogenesis.	Tetradecanoylphorbol Acetate	62-65	serine (or cysteine) peptidase inhibitor, clade B, member 2	Mus musculus	0-8
21480506-8	2011	Moreover, significant increases in the protein levels analyzed by ELISA of c-Jun, p65, and p53 were observed in the skin of DMBA/TPA treated mice, whereas mice treated with 2 and DMBA/TPA had a similar expression of these transcription factors than the control mice.	Tetradecanoylphorbol Acetate	129-132	jun proto-oncogene	Mus musculus	75-80
25359883-2	2014	It forms a complex with both focal adhesion kinase (FAK, also known as PTK2) and Src in SCC cells derived from skin carcinomas induced by administration of the chemical DMBA followed by TPA (the DMBA/TPA model).	Tetradecanoylphorbol Acetate	186-189	protein tyrosine kinase 2	Homo sapiens	29-50
21480506-8	2011	Moreover, significant increases in the protein levels analyzed by ELISA of c-Jun, p65, and p53 were observed in the skin of DMBA/TPA treated mice, whereas mice treated with 2 and DMBA/TPA had a similar expression of these transcription factors than the control mice.	Tetradecanoylphorbol Acetate	184-187	jun proto-oncogene	Mus musculus	75-80
21303260-3	2011	Topical application of 5 nmol of TPA to mouse ears markedly increased the ear weight, expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein, and phosphorylation of the inhibitor of kappaB (IkappaB) alpha, AKT, and extracellular signal-regulated protein kinase (ERK) 1/2 and reduced IkappaBalpha protein levels.	Tetradecanoylphorbol Acetate	33-36	mitogen-activated protein kinase 3	Mus musculus	252-307
21292826-6	2011	The SRF site alone is sufficient for induction by GnRH, whereas induction by 12-tetradecanoylphorbol-13-acetate (TPA) requires both the ELK1 and SRF sites.	Tetradecanoylphorbol Acetate	113-116	serum response factor	Mus musculus	145-148
25359883-2	2014	It forms a complex with both focal adhesion kinase (FAK, also known as PTK2) and Src in SCC cells derived from skin carcinomas induced by administration of the chemical DMBA followed by TPA (the DMBA/TPA model).	Tetradecanoylphorbol Acetate	186-189	protein tyrosine kinase 2	Homo sapiens	52-55
25359883-2	2014	It forms a complex with both focal adhesion kinase (FAK, also known as PTK2) and Src in SCC cells derived from skin carcinomas induced by administration of the chemical DMBA followed by TPA (the DMBA/TPA model).	Tetradecanoylphorbol Acetate	186-189	protein tyrosine kinase 2	Homo sapiens	71-75
21324306-5	2011	In a mouse edema model, PEP-1-catalase inhibited the increased expressions of inflammatory mediators and cytokines such as cyclooxygenase-2, inducible nitric oxide synthase, interleukin-6 and -1beta, and tumor necrosis factor-alpha induced by TPA.	Tetradecanoylphorbol Acetate	243-246	prostaglandin-endoperoxide synthase 2	Mus musculus	123-172
25359883-2	2014	It forms a complex with both focal adhesion kinase (FAK, also known as PTK2) and Src in SCC cells derived from skin carcinomas induced by administration of the chemical DMBA followed by TPA (the DMBA/TPA model).	Tetradecanoylphorbol Acetate	200-203	protein tyrosine kinase 2	Homo sapiens	29-50
25359883-2	2014	It forms a complex with both focal adhesion kinase (FAK, also known as PTK2) and Src in SCC cells derived from skin carcinomas induced by administration of the chemical DMBA followed by TPA (the DMBA/TPA model).	Tetradecanoylphorbol Acetate	200-203	protein tyrosine kinase 2	Homo sapiens	52-55
25359883-2	2014	It forms a complex with both focal adhesion kinase (FAK, also known as PTK2) and Src in SCC cells derived from skin carcinomas induced by administration of the chemical DMBA followed by TPA (the DMBA/TPA model).	Tetradecanoylphorbol Acetate	200-203	protein tyrosine kinase 2	Homo sapiens	71-75
25540590-9	2014	TPA also induced an early, marked phosphorylation/translocation of p65 (NF-kappaB), whereas NaF induced slower, less pronounced effects on p65.	Tetradecanoylphorbol Acetate	0-3	RELA proto-oncogene, NF-kB subunit	Homo sapiens	67-70
21121973-10	2011	Protein kinase C activation by phorbol 12-myristate 13-acetate also caused an ERK1/2-dependent increase in the serine 31 phosphorylation of tyrosine hydroxylase but, in contrast to the nicotinic response, was not accompanied by an increase in enzyme activity.	Tetradecanoylphorbol Acetate	31-62	mitogen-activated protein kinase 3	Bos taurus	78-84
21044683-4	2011	We previously showed that, in neonatal rat cardiac myocytes, endothelin-1 and phorbol 12-myristate 13-acetate (PMA) powerfully and rapidly (maximal at ~5 min) activate ERK1/2.	Tetradecanoylphorbol Acetate	78-109	mitogen activated protein kinase 1	Rattus norvegicus	168-174
25540590-10	2014	The CXCL8 responses by TPA and NaF were reduced by p65-siRNA.	Tetradecanoylphorbol Acetate	23-26	RELA proto-oncogene, NF-kB subunit	Homo sapiens	51-54
21044683-4	2011	We previously showed that, in neonatal rat cardiac myocytes, endothelin-1 and phorbol 12-myristate 13-acetate (PMA) powerfully and rapidly (maximal at ~5 min) activate ERK1/2.	Tetradecanoylphorbol Acetate	111-114	mitogen activated protein kinase 1	Rattus norvegicus	168-174
25520561-4	2014	We found that all cavin-1, -2 and -3 transcripts were expressed and that treatment with phorbol 12-myristate 13-acetate (PMA), which is known to prime cell migration and proliferation, specifically upregulated cavin-3 gene and protein expression.	Tetradecanoylphorbol Acetate	88-119	caveolae associated protein 1	Homo sapiens	18-36
21044683-10	2011	Monophosphothreonyl ERK1/2 represented maximally ~30% of total ERK1/2 activity after stimulation with endothelin-1 or PMA, and their k(cat) values were estimated to be minimally ~30% of the dually-phosphorylated species.	Tetradecanoylphorbol Acetate	118-121	mitogen activated protein kinase 1	Rattus norvegicus	20-26
21044683-10	2011	Monophosphothreonyl ERK1/2 represented maximally ~30% of total ERK1/2 activity after stimulation with endothelin-1 or PMA, and their k(cat) values were estimated to be minimally ~30% of the dually-phosphorylated species.	Tetradecanoylphorbol Acetate	118-121	mitogen activated protein kinase 1	Rattus norvegicus	63-69
21062642-2	2011	In HEK293 and Jurkat cells, the Ca2(+) release and Ca2(+) uptake stimulated by several different activators were attenuated by activation of PKC with phorbol myristate acetate (PMA) or 1-oleoyl-2-acetyl-sn-glycerol (OAG) and potentiated by PKC inhibition with Go6983 or knockdown of PKCalpha or PKCbeta using shRNA.	Tetradecanoylphorbol Acetate	150-175	protein kinase C beta	Homo sapiens	295-302
21062642-2	2011	In HEK293 and Jurkat cells, the Ca2(+) release and Ca2(+) uptake stimulated by several different activators were attenuated by activation of PKC with phorbol myristate acetate (PMA) or 1-oleoyl-2-acetyl-sn-glycerol (OAG) and potentiated by PKC inhibition with Go6983 or knockdown of PKCalpha or PKCbeta using shRNA.	Tetradecanoylphorbol Acetate	177-180	protein kinase C beta	Homo sapiens	295-302
25520561-4	2014	We found that all cavin-1, -2 and -3 transcripts were expressed and that treatment with phorbol 12-myristate 13-acetate (PMA), which is known to prime cell migration and proliferation, specifically upregulated cavin-3 gene and protein expression.	Tetradecanoylphorbol Acetate	121-124	caveolae associated protein 1	Homo sapiens	18-36
25297509-8	2014	Primary-cultured skin keratinocytes from CKO mice also showed reduced expression of these cytokines and weak activation of Rap1 compared with those from control mice after the TPA treatment.	Tetradecanoylphorbol Acetate	176-179	RAS-related protein 1a	Mus musculus	123-127
21129147-7	2011	METHODS/RESULTS: Chromatin immunoprecipitation and gel-shift assays with phorbol 12-myristate 13-acetate-treated human erythroleukemia (HEL) cells revealed RUNX1 binding to RUNX1 consensus sites at -1774/-1769 and -157/-152 on the PF4 promoter.	Tetradecanoylphorbol Acetate	73-104	platelet factor 4	Homo sapiens	231-234
22178385-5	2012	In reconstituted phox-competent K562 cells, siRNA-mediated suppression of Prdx6 resulted in decreased NADPH oxidase activity in response to formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	188-213	peroxiredoxin 6	Homo sapiens	74-79
22178385-5	2012	In reconstituted phox-competent K562 cells, siRNA-mediated suppression of Prdx6 resulted in decreased NADPH oxidase activity in response to formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	215-218	peroxiredoxin 6	Homo sapiens	74-79
22178385-6	2012	In neutrophils stimulated with PMA, Prdx6 translocated to plasma membrane as demonstrated by Western blot and confocal microscopy.	Tetradecanoylphorbol Acetate	31-34	peroxiredoxin 6	Homo sapiens	36-41
22188018-12	2012	In agreement, the phosphomimetic mutant, Rab11 S177D, retains transferrin at the ERC in the absence of phorbol-12-myristate-13-acetate stimulus.	Tetradecanoylphorbol Acetate	103-134	RAB11A, member RAS oncogene family	Homo sapiens	41-46
22109886-6	2012	The effects of GHRH/ghrelin were completely mimicked by forskolin (adenylate cyclase activator) and phorbol 12-myristate 13-acetate (protein kinase C activator), respectively, indicating the regulation of receptor subtype levels by GHRH and ghrelin involved distinct signaling pathways.	Tetradecanoylphorbol Acetate	100-131	somatoliberin	Papio anubis	15-19
22109886-6	2012	The effects of GHRH/ghrelin were completely mimicked by forskolin (adenylate cyclase activator) and phorbol 12-myristate 13-acetate (protein kinase C activator), respectively, indicating the regulation of receptor subtype levels by GHRH and ghrelin involved distinct signaling pathways.	Tetradecanoylphorbol Acetate	100-131	somatoliberin	Papio anubis	232-236
22002060-4	2011	Activation of protein kinase C with phorbol 12-myristate 13-acetate resulted in phosphorylation of endogenous MT1-MMP at Thr(567) in vivo.	Tetradecanoylphorbol Acetate	36-67	matrix metallopeptidase 14	Homo sapiens	110-117
22210038-2	2011	Heat-inactivated LP (heated at 60 C for 30 min) potently inhibited the expression of TNF-alpha and IL-4 as well as the activation of their transcription factors, NF-kappaB and c-jun, in phorbol 12"-myristate 13"-acetate-stimulated RBL-2H3 cells.	Tetradecanoylphorbol Acetate	186-219	jun proto-oncogene	Mus musculus	176-181
22001392-5	2011	We first demonstrate that AP-1 activation by 12-O-tetradecanoylphorbol-13-acetate induces PTPROt expression with concurrent recruitment of c-fos and c-jun to its promoter.	Tetradecanoylphorbol Acetate	45-81	jun proto-oncogene	Mus musculus	26-30
22001392-5	2011	We first demonstrate that AP-1 activation by 12-O-tetradecanoylphorbol-13-acetate induces PTPROt expression with concurrent recruitment of c-fos and c-jun to its promoter.	Tetradecanoylphorbol Acetate	45-81	jun proto-oncogene	Mus musculus	149-154
22160590-6	2011	In HPAC cells treated with TPA, downregulation of claudin-1 and mislocalization of claudin-4 and occludin around the nuclei were observed, together with a decrease in the numbers of tight junction strands and an increase in phosphorylation of claudin-4.	Tetradecanoylphorbol Acetate	27-30	occludin	Homo sapiens	97-105
22346774-0	2011	NDRG2 Promotes GATA-1 Expression through Regulation of the JAK2/STAT Pathway in PMA-stimulated U937 Cells.	Tetradecanoylphorbol Acetate	80-83	Janus kinase 2	Homo sapiens	59-63
21400615-4	2011	Western blot analysis revealed that 5"-NIO inhibited activities of Raf-1 (S338), MEK1/2, ERK1/2, JNK, and c-Jun induced by EGF or TPA, respectively, whereas it did not affect autophosphorylation of epidermal growth factor receptor (EGFR) induced by EGF or TPA.	Tetradecanoylphorbol Acetate	130-133	mitogen-activated protein kinase kinase 1	Mus musculus	81-87
21400615-4	2011	Western blot analysis revealed that 5"-NIO inhibited activities of Raf-1 (S338), MEK1/2, ERK1/2, JNK, and c-Jun induced by EGF or TPA, respectively, whereas it did not affect autophosphorylation of epidermal growth factor receptor (EGFR) induced by EGF or TPA.	Tetradecanoylphorbol Acetate	130-133	mitogen-activated protein kinase 3	Mus musculus	89-95
21400615-4	2011	Western blot analysis revealed that 5"-NIO inhibited activities of Raf-1 (S338), MEK1/2, ERK1/2, JNK, and c-Jun induced by EGF or TPA, respectively, whereas it did not affect autophosphorylation of epidermal growth factor receptor (EGFR) induced by EGF or TPA.	Tetradecanoylphorbol Acetate	130-133	jun proto-oncogene	Mus musculus	106-111
21400615-5	2011	In addition, 5"-NIO exerted strong inhibitory effects on the EGF- or TPA-induced c-fos or c-jun transcriptional activity, and thereby inhibited the associated activator protein-1 (AP-1) transactivation activity induced by EGF or TPA.	Tetradecanoylphorbol Acetate	69-72	jun proto-oncogene	Mus musculus	90-95
21400615-5	2011	In addition, 5"-NIO exerted strong inhibitory effects on the EGF- or TPA-induced c-fos or c-jun transcriptional activity, and thereby inhibited the associated activator protein-1 (AP-1) transactivation activity induced by EGF or TPA.	Tetradecanoylphorbol Acetate	69-72	jun proto-oncogene	Mus musculus	159-178
21400615-5	2011	In addition, 5"-NIO exerted strong inhibitory effects on the EGF- or TPA-induced c-fos or c-jun transcriptional activity, and thereby inhibited the associated activator protein-1 (AP-1) transactivation activity induced by EGF or TPA.	Tetradecanoylphorbol Acetate	69-72	jun proto-oncogene	Mus musculus	180-184
21400615-5	2011	In addition, 5"-NIO exerted strong inhibitory effects on the EGF- or TPA-induced c-fos or c-jun transcriptional activity, and thereby inhibited the associated activator protein-1 (AP-1) transactivation activity induced by EGF or TPA.	Tetradecanoylphorbol Acetate	229-232	jun proto-oncogene	Mus musculus	159-178
21400615-5	2011	In addition, 5"-NIO exerted strong inhibitory effects on the EGF- or TPA-induced c-fos or c-jun transcriptional activity, and thereby inhibited the associated activator protein-1 (AP-1) transactivation activity induced by EGF or TPA.	Tetradecanoylphorbol Acetate	229-232	jun proto-oncogene	Mus musculus	180-184
22009531-6	2011	Exposure to DMBA and TPA activated p53 and decreased MnSOD expression via p53-mediated suppression of Sp1 binding to the MnSOD promoter in normal-appearing skin and benign papillomas.	Tetradecanoylphorbol Acetate	21-24	superoxide dismutase 2	Homo sapiens	53-58
22009531-6	2011	Exposure to DMBA and TPA activated p53 and decreased MnSOD expression via p53-mediated suppression of Sp1 binding to the MnSOD promoter in normal-appearing skin and benign papillomas.	Tetradecanoylphorbol Acetate	21-24	superoxide dismutase 2	Homo sapiens	121-126
21165949-7	2011	The expression of ST3Gal I and II was mildly induced by phorbol-12-myristate-13-acetate (PMA), and PMA-induced expression of ST3Gal I and ST3Gal II was inhibited by NF-kappaB decoy oligodeoxynucleotides (ODN) but not by AP-1 decoy ODN.	Tetradecanoylphorbol Acetate	56-87	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	138-147
21165949-7	2011	The expression of ST3Gal I and II was mildly induced by phorbol-12-myristate-13-acetate (PMA), and PMA-induced expression of ST3Gal I and ST3Gal II was inhibited by NF-kappaB decoy oligodeoxynucleotides (ODN) but not by AP-1 decoy ODN.	Tetradecanoylphorbol Acetate	99-102	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	138-147
24114993-1	2014	In this study, we examined the impact of rapamycin on mTORC1 signaling during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced keratinocyte proliferation and skin tumor promotion in both wild-type (FVB/N) and BK5.Akt(WT) mice.	Tetradecanoylphorbol Acetate	78-114	CREB regulated transcription coactivator 1	Mus musculus	54-60
24114993-1	2014	In this study, we examined the impact of rapamycin on mTORC1 signaling during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced keratinocyte proliferation and skin tumor promotion in both wild-type (FVB/N) and BK5.Akt(WT) mice.	Tetradecanoylphorbol Acetate	116-119	CREB regulated transcription coactivator 1	Mus musculus	54-60
24114993-2	2014	TPA activated mTORC1 signaling in a time-dependent manner in cultured primary mouse keratinocytes and a mouse keratinocyte cell line.	Tetradecanoylphorbol Acetate	0-3	CREB regulated transcription coactivator 1	Mus musculus	14-20
24114993-3	2014	Early activation (15-30 min) of mTORC1 signaling induced by TPA was mediated in part by PKC activation, whereas later activation (2-4 h) was mediated by activation of EGFR and Akt.	Tetradecanoylphorbol Acetate	60-63	CREB regulated transcription coactivator 1	Mus musculus	32-38
24114993-5	2014	Targeting mTORC1 with rapamycin effectively inhibited TPA-induced epidermal hyperplasia and hyperproliferation as well as tumor promotion in a dose-dependent manner in both wild-type and BK5.Akt(WT) mice.	Tetradecanoylphorbol Acetate	54-57	CREB regulated transcription coactivator 1	Mus musculus	10-16
25022544-7	2014	To determine the role of PKC activation in the effects of DPP-4 inhibitors, cells were treated with PMA- which blocked the effect of DPP-4 inhibitors on NLRP3 and IL-1beta as well as TLR4 and GLP-1R.	Tetradecanoylphorbol Acetate	100-103	glucagon like peptide 1 receptor	Homo sapiens	192-198
25172501-7	2014	Treatment with the MIF antagonist (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester considerably attenuated TPA-induced ear swelling, leukocyte infiltration, epidermal cell proliferation, and dermal angiogenesis.	Tetradecanoylphorbol Acetate	133-136	macrophage migration inhibitory factor	Homo sapiens	19-22
25038525-7	2014	TPA enhanced the frequency and size of lumen formation and correlated with a robust increase in phosphorylation of p42/p44 Erk kinase, while S1P and SDF did not.	Tetradecanoylphorbol Acetate	0-3	proteasome 26S subunit, ATPase 6	Homo sapiens	115-118
25143809-4	2014	In the present study, we show that heterochromatin 1 gamma (HP1gamma) plays a negative role in TPA-induced c-Jun and c-Fos expression.	Tetradecanoylphorbol Acetate	95-98	chromobox 3	Homo sapiens	60-68
25143809-5	2014	We show that TPA-induced Akt1 directly phosphorylates HP1gamma, abrogates its suppressive function and increases the interaction between histone H3 and 14-3-3epsilon.	Tetradecanoylphorbol Acetate	13-16	chromobox 3	Homo sapiens	54-62
24654232-8	2014	Stimulation of control SSM with phorbol 12-myristate 13-acetate (PMA), a PKC activator, increased both calcium tolerance and mitochondrial Cx43 phosphorylation at S262 and S368.	Tetradecanoylphorbol Acetate	32-63	gap junction protein alpha 1	Homo sapiens	139-143
24654232-8	2014	Stimulation of control SSM with phorbol 12-myristate 13-acetate (PMA), a PKC activator, increased both calcium tolerance and mitochondrial Cx43 phosphorylation at S262 and S368.	Tetradecanoylphorbol Acetate	65-68	gap junction protein alpha 1	Homo sapiens	139-143
24732112-5	2014	Furthermore, the effect of the extracts, EUG and IMT, was studied on phorbol-12-myristate-13-acetate (PMA) induced monocyte to macrophage differentiation and gene expression of CD14, TLR2 and TLR4.	Tetradecanoylphorbol Acetate	102-105	CD14 molecule	Homo sapiens	177-181
24732112-10	2014	In addition, they showed significant inhibition on PMA induced monocyte to macrophage differentiation and the gene expression of CD14, TLR2 and TLR4 markers.	Tetradecanoylphorbol Acetate	51-54	CD14 molecule	Homo sapiens	129-133
24744737-8	2014	Moreover, TPA induced the phosphorylation of MARCKS, which is a membrane-substrate of PKC, resulting in the translocation of phosphorylated MARCKS to the perinuclear region, suggesting that TPA induces macropinocytosis via gammaPKC activation.	Tetradecanoylphorbol Acetate	10-13	myristoylated alanine rich protein kinase C substrate	Homo sapiens	45-51
24744737-8	2014	Moreover, TPA induced the phosphorylation of MARCKS, which is a membrane-substrate of PKC, resulting in the translocation of phosphorylated MARCKS to the perinuclear region, suggesting that TPA induces macropinocytosis via gammaPKC activation.	Tetradecanoylphorbol Acetate	10-13	myristoylated alanine rich protein kinase C substrate	Homo sapiens	140-146
24744737-8	2014	Moreover, TPA induced the phosphorylation of MARCKS, which is a membrane-substrate of PKC, resulting in the translocation of phosphorylated MARCKS to the perinuclear region, suggesting that TPA induces macropinocytosis via gammaPKC activation.	Tetradecanoylphorbol Acetate	190-193	myristoylated alanine rich protein kinase C substrate	Homo sapiens	45-51
24744737-8	2014	Moreover, TPA induced the phosphorylation of MARCKS, which is a membrane-substrate of PKC, resulting in the translocation of phosphorylated MARCKS to the perinuclear region, suggesting that TPA induces macropinocytosis via gammaPKC activation.	Tetradecanoylphorbol Acetate	190-193	myristoylated alanine rich protein kinase C substrate	Homo sapiens	140-146
24515436-5	2014	Ankrd1 deletion enhanced both basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP13 promoter activity; conversely, Ankrd1 overexpression in control cells decreased PMA-induced MMP13 promoter activity.	Tetradecanoylphorbol Acetate	40-71	matrix metallopeptidase 13	Mus musculus	86-91
24515436-5	2014	Ankrd1 deletion enhanced both basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP13 promoter activity; conversely, Ankrd1 overexpression in control cells decreased PMA-induced MMP13 promoter activity.	Tetradecanoylphorbol Acetate	73-76	matrix metallopeptidase 13	Mus musculus	86-91
24515436-5	2014	Ankrd1 deletion enhanced both basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP13 promoter activity; conversely, Ankrd1 overexpression in control cells decreased PMA-induced MMP13 promoter activity.	Tetradecanoylphorbol Acetate	172-175	matrix metallopeptidase 13	Mus musculus	184-189
24495782-8	2014	The results showed that HHStecs expressed PAR2, which was up regulated by activation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	90-115	F2R like trypsin receptor 1	Homo sapiens	42-46
24495782-8	2014	The results showed that HHStecs expressed PAR2, which was up regulated by activation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	117-120	F2R like trypsin receptor 1	Homo sapiens	42-46
24495782-10	2014	Exposure to PMA induced HHStec apoptosis, which was significantly inhibited by activation of PAR2.	Tetradecanoylphorbol Acetate	12-15	F2R like trypsin receptor 1	Homo sapiens	93-97
24258363-4	2014	In addition, the MSE inhibitory effect on upstream of NFkappaB was found to involve the transcriptional effects of MAPK signaling as indicated by strong suppression on TPA-induced activation of extracellular signal regulate kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt.	Tetradecanoylphorbol Acetate	168-171	mitogen-activated protein kinase 3	Mus musculus	194-239
24258363-4	2014	In addition, the MSE inhibitory effect on upstream of NFkappaB was found to involve the transcriptional effects of MAPK signaling as indicated by strong suppression on TPA-induced activation of extracellular signal regulate kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt.	Tetradecanoylphorbol Acetate	168-171	mitogen-activated protein kinase 14	Mus musculus	241-244
24297175-8	2014	Arginine vasopressin (100 and 500 pm) and the PKC activator phorbol 12-myristate 13-acetate (1 nm) each inhibited human (h) Kv7.5 and hKv7.4/7.5, but not hKv7.4 channels expressed in A7r5 cells.	Tetradecanoylphorbol Acetate	60-91	potassium voltage-gated channel subfamily Q member 5	Homo sapiens	124-129
24094605-2	2014	OBJECTIVE: To evaluate the impact of alterations in fibrin structure mediated by constitutive carboxypeptidase activity on the function of fibrin as a template for tissue plasminogen activator-(tPA) induced plasminogen activation and its susceptibility to digestion by plasmin.	Tetradecanoylphorbol Acetate	194-197	plasminogen	Homo sapiens	171-178
24067898-10	2013	Immunohistochemistry confirmed higher MMP9 staining in 12-O-tetradecanoylphorbol-13-acetate-treated skin from Tpl2 (-/-) mice and grafted tumors formed from v-ras(Ha) retrovirus-infected Tpl2 (-/-) keratinocytes.	Tetradecanoylphorbol Acetate	55-91	matrix metallopeptidase 9	Mus musculus	38-42
24008507-7	2013	Similar to the inhibitory effects shown in MDA-MB-231 cells, we observed that DSW treatment resulted in the inhibition of TPA-induced migration and MMP-9 activity with a concomitant decrease in mRNA levels of MMP-9, TGF-beta, Wnt5a and Wnt3a.	Tetradecanoylphorbol Acetate	122-125	Wnt family member 3A	Homo sapiens	236-241
23900236-10	2013	U-2OS osteosarcoma cells showed strong bands corresponding to inactive MMP-2 and MMP-9 and faint bands corresponding to active MMP-2 and MMP-9 dimer; PMA treatment enhanced MMP-9 and MMP-9 dimer activity.	Tetradecanoylphorbol Acetate	150-153	matrix metallopeptidase 2	Homo sapiens	71-76
23900236-10	2013	U-2OS osteosarcoma cells showed strong bands corresponding to inactive MMP-2 and MMP-9 and faint bands corresponding to active MMP-2 and MMP-9 dimer; PMA treatment enhanced MMP-9 and MMP-9 dimer activity.	Tetradecanoylphorbol Acetate	150-153	matrix metallopeptidase 2	Homo sapiens	127-132
23900415-8	2013	Inhibition of activin signaling during PKC stimulation through silencing of the inhibin betaA-subunit or blocking of the activin type I receptor opposed the PMA-induced downregulation of CYP17A1 expression and P450c17 function.	Tetradecanoylphorbol Acetate	157-160	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	187-194
23900415-8	2013	Inhibition of activin signaling during PKC stimulation through silencing of the inhibin betaA-subunit or blocking of the activin type I receptor opposed the PMA-induced downregulation of CYP17A1 expression and P450c17 function.	Tetradecanoylphorbol Acetate	157-160	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	210-217
23911786-3	2013	Pretreatment of female HR-1 hairless mouse skin with TQ attenuated 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of cyclooxygenase-2 (COX-2).	Tetradecanoylphorbol Acetate	67-103	prostaglandin-endoperoxide synthase 2	Mus musculus	132-148
23911786-3	2013	Pretreatment of female HR-1 hairless mouse skin with TQ attenuated 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of cyclooxygenase-2 (COX-2).	Tetradecanoylphorbol Acetate	67-103	prostaglandin-endoperoxide synthase 2	Mus musculus	150-155
23911786-3	2013	Pretreatment of female HR-1 hairless mouse skin with TQ attenuated 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of cyclooxygenase-2 (COX-2).	Tetradecanoylphorbol Acetate	105-108	prostaglandin-endoperoxide synthase 2	Mus musculus	132-148
23911786-3	2013	Pretreatment of female HR-1 hairless mouse skin with TQ attenuated 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of cyclooxygenase-2 (COX-2).	Tetradecanoylphorbol Acetate	105-108	prostaglandin-endoperoxide synthase 2	Mus musculus	150-155
23911786-7	2013	Taken together, the inhibitory effects of TQ on TPA-induced COX-2 expression and NF-kappaB activation, and its ability to induce the expression of cytoprotective proteins provide a mechanistic basis of anti-inflammatory and antioxidative effects of TQ in hairless mouse skin.	Tetradecanoylphorbol Acetate	48-51	prostaglandin-endoperoxide synthase 2	Mus musculus	60-65
23939428-10	2013	Using RNA interference technology, we also found that down-regulated Skp2 reduced the phosphorylation level of MEK1 and significantly reversed TPA-induced nuclear export of PPARgamma in MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	143-146	S-phase kinase associated protein 2	Homo sapiens	69-73
23603832-4	2013	With phorbol myristate acetate, lipopolysaccharide or Staphylococcus aureus Prx2 dimer increased from &lt;5% to up to 100% depending on neutrophil number and incubation time.	Tetradecanoylphorbol Acetate	5-30	peroxiredoxin 2	Mus musculus	76-80
23612789-4	2013	By monitoring surface-labeled DAT in transfected dopamine neurons from embryonic rat mesencephalic cultures, we find distinct sorting and fates of internalized DAT after amphetamine or PMA treatment.	Tetradecanoylphorbol Acetate	185-188	solute carrier family 6 member 3	Rattus norvegicus	30-33
23612789-4	2013	By monitoring surface-labeled DAT in transfected dopamine neurons from embryonic rat mesencephalic cultures, we find distinct sorting and fates of internalized DAT after amphetamine or PMA treatment.	Tetradecanoylphorbol Acetate	185-188	solute carrier family 6 member 3	Rattus norvegicus	160-163
23612789-5	2013	Although both drugs promote DAT internalization above constitutive endocytosis in dopamine neurons, PMA induces ubiquitination of DAT and leads to accumulation of DAT on LAMP1-positive endosomes.	Tetradecanoylphorbol Acetate	100-103	solute carrier family 6 member 3	Rattus norvegicus	130-133
23612789-5	2013	Although both drugs promote DAT internalization above constitutive endocytosis in dopamine neurons, PMA induces ubiquitination of DAT and leads to accumulation of DAT on LAMP1-positive endosomes.	Tetradecanoylphorbol Acetate	100-103	solute carrier family 6 member 3	Rattus norvegicus	130-133
23578765-2	2013	Using the Hv1 inhibitor Zn(2+), we found that the PMA-induced respiratory burst of human neutrophils is inhibited when assessed as extracellular production of O2(-) and H2O2, in accordance with literature studies, but, surprisingly, unaffected when measured as oxygen consumption or total (extracellular plus intracellular) H2O2 production.	Tetradecanoylphorbol Acetate	50-53	hydrogen voltage gated channel 1	Homo sapiens	10-13
23769052-14	2013	In contrast, CD4(+) CD25(+) FoxP3(+) CD127(-) Treg are inducible by PMA/ionomycin and PHA stimulation.	Tetradecanoylphorbol Acetate	68-71	forkhead box P3	Homo sapiens	28-33
23114726-0	2013	Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 breast adenocarcinoma cells invasion/migration by alpha-tomatine through activating PKCalpha/ERK/NF-kappaB-dependent MMP-2/MMP-9 expressions.	Tetradecanoylphorbol Acetate	15-51	matrix metallopeptidase 2	Homo sapiens	183-188
21264284-9	2011	Furthermore, PMA treatment of CIB1 overexpressing cells led to increased ploidy compared to PMA treated control cells.	Tetradecanoylphorbol Acetate	13-16	calcium and integrin binding 1	Homo sapiens	30-34
23335792-4	2013	phorbol 12-myristate 13-acetate-activated THP-1 macrophages were transfected with negative control or MyD88 small interfering (si)RNA.	Tetradecanoylphorbol Acetate	0-31	MYD88 innate immune signal transduction adaptor	Homo sapiens	102-107
21264284-9	2011	Furthermore, PMA treatment of CIB1 overexpressing cells led to increased ploidy compared to PMA treated control cells.	Tetradecanoylphorbol Acetate	92-95	calcium and integrin binding 1	Homo sapiens	30-34
21720001-9	2011	Moreover, a synthetic analog of diacylglycerol (DG), phorbol 12-myristate 13 acetate (TPA; 10(-7) M), potentiated PDGF-induced ERK2 phosphorylation, while ionomycin had no effect (10(-6) M).	Tetradecanoylphorbol Acetate	53-84	mitogen activated protein kinase 1	Rattus norvegicus	127-131
23223576-8	2013	Exogenously added diacylglycerol or phorbol 12-myristate 13-acetate, known activators of PKC, leads to rpS6 phosphorylation in a rapamycin-dependent manner.	Tetradecanoylphorbol Acetate	36-67	ribosomal protein S6	Mus musculus	103-107
21720001-9	2011	Moreover, a synthetic analog of diacylglycerol (DG), phorbol 12-myristate 13 acetate (TPA; 10(-7) M), potentiated PDGF-induced ERK2 phosphorylation, while ionomycin had no effect (10(-6) M).	Tetradecanoylphorbol Acetate	86-89	mitogen activated protein kinase 1	Rattus norvegicus	127-131
23392873-8	2013	Activation of PKC by phorbol 12-myristate-13-acetate (1 muM) reduced TauT activity by 18% (p &lt; 0.05).	Tetradecanoylphorbol Acetate	21-52	solute carrier family 6 member 6	Homo sapiens	69-73
21963497-5	2011	A fluorescein isothiocyanate (FITC)-conjugated PI polyamide to CTGF permeated cell membranes and accumulated in the nuclei of cultured human mesangial cells (HMCs) and remained there for 48 h. The PI polyamide to hCTGF significantly decreased phorbol 12-myristate acetate (PMA)- or transforming growth factor-beta1 (TGF-beta1)-stimulated luciferase activity of the hCTGF promoter in cultured HMCs.	Tetradecanoylphorbol Acetate	273-276	cellular communication network factor 2	Homo sapiens	63-67
21646795-8	2011	Tr1 cells were defined as CD4+CD25+ T cells that predominantly produce IL-10 when costimulated with phorbol myristate acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	100-125	taste 1 receptor member 1	Homo sapiens	0-3
23128164-5	2013	To assess the morphological modification and expression of LH/CG-R Delta9 in human macrophages after hCG exposure, the present study examined phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells, a human monocyte-macrophage cell line.	Tetradecanoylphorbol Acetate	175-178	chorionic gonadotropin subunit beta 5	Homo sapiens	62-64
21646795-8	2011	Tr1 cells were defined as CD4+CD25+ T cells that predominantly produce IL-10 when costimulated with phorbol myristate acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	127-130	taste 1 receptor member 1	Homo sapiens	0-3
21077177-4	2011	Recently, the reduction of Cu/Zn-SOD and the induction of Mn-SOD by TPA in leukemic cells have been reported; however, the regulation of EC-SOD by TPA remains poorly understood.	Tetradecanoylphorbol Acetate	68-71	superoxide dismutase 2	Homo sapiens	58-64
21869566-3	2011	When cells were incubated with sodium nitroprusside (SNP), phorbol 12-myristate 13-acetate, forskolin, lipopolysaccharide, or interferon-gamma, only SNP inhibited NT5E activity in a time- and concentration-dependent manner (IC(50) = 1.2 microM).	Tetradecanoylphorbol Acetate	59-90	5'-nucleotidase ecto	Homo sapiens	163-167
23128164-6	2013	hCG induced transient vacuole formation in PMA-treated THP-1 cells, morphologically mimicking Hofbauer cells.	Tetradecanoylphorbol Acetate	43-46	chorionic gonadotropin subunit beta 5	Homo sapiens	0-3
23128164-7	2013	Immunocytochemistry showed that PMA-treated THP-1 cells incorporated hCG but not luteinizing hormone or follicle-stimulating hormone.	Tetradecanoylphorbol Acetate	32-35	chorionic gonadotropin subunit beta 5	Homo sapiens	69-72
21131601-5	2011	With low-dose phorbol 12-myristate 13-acetate (PMA) or anti-IgM treatment, TGF-beta sensitivity was restored by stabilizing TbetaRII expression and sustaining TGF-beta signaling.	Tetradecanoylphorbol Acetate	14-45	transforming growth factor beta receptor 2	Homo sapiens	124-132
21131601-5	2011	With low-dose phorbol 12-myristate 13-acetate (PMA) or anti-IgM treatment, TGF-beta sensitivity was restored by stabilizing TbetaRII expression and sustaining TGF-beta signaling.	Tetradecanoylphorbol Acetate	47-50	transforming growth factor beta receptor 2	Homo sapiens	124-132
23128164-8	2013	Western blotting analyses demonstrated that PMA-treated THP-1 cells expressed an immunoreactive 60-kDa protein, designated as endogenous LH/CG-R Delta9.	Tetradecanoylphorbol Acetate	44-47	chorionic gonadotropin subunit beta 5	Homo sapiens	140-142
23711861-8	2013	Furthermore, the ex vivo production of interleukin (IL)-5 by PBMCs in response to both mite allergen and ionomycin/PMA decreased significantly.	Tetradecanoylphorbol Acetate	115-118	interleukin 5	Homo sapiens	39-57
21151895-4	2010	Combination therapy with tPA plus cilostazol prevented development of hemorrhagic transformation, reduced brain edema, prevented endothelial injury via reduction MMP-9 activity, and prevented the blood-brain barrier opening by inhibiting decreased claudin-5 expression.	Tetradecanoylphorbol Acetate	25-28	matrix metallopeptidase 9	Mus musculus	162-167
21187486-9	2010	CONCLUSION: Consistent with these findings, the inhibition of PKC prevented PTHrP-induced activation of ERK1/2, whereas 12-O-tetradecanoylphorbol-13-acetate (TPA), a stimulator of PKC, up-regulated the PTHrP-induced activation of ERK1/2.	Tetradecanoylphorbol Acetate	120-156	parathyroid hormone like hormone	Homo sapiens	202-207
21187486-9	2010	CONCLUSION: Consistent with these findings, the inhibition of PKC prevented PTHrP-induced activation of ERK1/2, whereas 12-O-tetradecanoylphorbol-13-acetate (TPA), a stimulator of PKC, up-regulated the PTHrP-induced activation of ERK1/2.	Tetradecanoylphorbol Acetate	158-161	parathyroid hormone like hormone	Homo sapiens	202-207
20966433-6	2010	We used quantitative polymerase chain reaction, western blotting, and immunohistochemistry to verify induction of Gsta4 in mouse epidermis following TPA treatment and biochemical assays to associate Gsta4 activity with tumor promotion susceptibility.	Tetradecanoylphorbol Acetate	149-152	glutathione S-transferase, alpha 4	Mus musculus	114-119
20966433-10	2010	Gsta4 maps to Psl1.2 and was highly induced (mRNA and protein) in the epidermis of resistant C57BL/6 mice compared with that of sensitive DBA/2 mice following treatment with TPA.	Tetradecanoylphorbol Acetate	174-177	glutathione S-transferase, alpha 4	Mus musculus	0-5
20966433-11	2010	Gsta4 activity levels were also higher in the epidermis of C57BL/6 mice following treatment with TPA.	Tetradecanoylphorbol Acetate	97-100	glutathione S-transferase, alpha 4	Mus musculus	0-5
20966433-12	2010	Gsta4-deficient mice (C57BL/6.Gsta4(-/-) mice) were more sensitive to TPA skin tumor promotion (0.8 tumors per mouse vs 0.4 tumors per mouse in wild-type controls; difference = 0.4 tumors per mouse; 95% confidence interval = 0.1 to 0.7, P = .007).	Tetradecanoylphorbol Acetate	70-73	glutathione S-transferase, alpha 4	Mus musculus	0-5
23451083-15	2013	Both telmisartan and candesartan did not inhibit TPA-induced EGFR phosphorylation, and telmisartan, but not candesartan, inhibited TPA-induced nuclear translocation of HB-EGF-CTF after knockdown of AT1R.	Tetradecanoylphorbol Acetate	131-134	angiotensin II receptor type 1	Homo sapiens	198-202
20810567-7	2010	Interestingly, PKCalpha, PKCbetaII, and PKCepsilon translocation to the plasma membrane was more pronounced and more prolonged in phorbol-12-myristate-13-acetate (PMA) than in GnRH-treated cells.	Tetradecanoylphorbol Acetate	130-161	protein kinase C, epsilon	Mus musculus	40-50
20810567-7	2010	Interestingly, PKCalpha, PKCbetaII, and PKCepsilon translocation to the plasma membrane was more pronounced and more prolonged in phorbol-12-myristate-13-acetate (PMA) than in GnRH-treated cells.	Tetradecanoylphorbol Acetate	163-166	protein kinase C, epsilon	Mus musculus	40-50
22981962-0	2012	Soy isoflavones (daidzein &amp; genistein) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cutaneous inflammation via modulation of COX-2 and NF-kappaB in Swiss albino mice.	Tetradecanoylphorbol Acetate	51-87	cytochrome c oxidase II, mitochondrial	Mus musculus	143-148
20652762-0	2010	Alpha-mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells.	Tetradecanoylphorbol Acetate	27-58	protein tyrosine kinase 2	Homo sapiens	116-119
20652762-1	2010	The purpose of this study is to investigate the anti-metastatic effect of alpha-mangostin on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in A549 human lung adenocarcinoma cells.	Tetradecanoylphorbol Acetate	93-124	matrix metallopeptidase 2	Homo sapiens	139-165
20652762-1	2010	The purpose of this study is to investigate the anti-metastatic effect of alpha-mangostin on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in A549 human lung adenocarcinoma cells.	Tetradecanoylphorbol Acetate	93-124	matrix metallopeptidase 2	Homo sapiens	167-172
20652762-1	2010	The purpose of this study is to investigate the anti-metastatic effect of alpha-mangostin on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in A549 human lung adenocarcinoma cells.	Tetradecanoylphorbol Acetate	126-129	matrix metallopeptidase 2	Homo sapiens	139-165
22981962-0	2012	Soy isoflavones (daidzein &amp; genistein) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cutaneous inflammation via modulation of COX-2 and NF-kappaB in Swiss albino mice.	Tetradecanoylphorbol Acetate	89-92	cytochrome c oxidase II, mitochondrial	Mus musculus	143-148
22981962-10	2012	Thus, our results suggest that inhibitory effect of SIF on TPA-induced cutaneous inflammation includes inhibition of proinflammatory cytokines, attenuation of oxidative stress, activation of NF-kappaB and expression of COX-2.	Tetradecanoylphorbol Acetate	59-62	cytochrome c oxidase II, mitochondrial	Mus musculus	219-224
23105093-6	2012	Both supershift and ChIP assays revealed the presence of the AP-1 component c-JUN at the PED/PEA-15 promoter upon 12-O-tetradecanoylphorbol-13-acetate stimulation of the cells.	Tetradecanoylphorbol Acetate	114-150	jun proto-oncogene	Mus musculus	76-81
20607724-4	2010	12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed expression of pdcd4 mRNA in human monocytic cell lines (U937, THP-1).	Tetradecanoylphorbol Acetate	0-36	programmed cell death 4	Homo sapiens	68-73
20607724-4	2010	12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed expression of pdcd4 mRNA in human monocytic cell lines (U937, THP-1).	Tetradecanoylphorbol Acetate	38-41	programmed cell death 4	Homo sapiens	68-73
20607724-8	2010	Consistently, in MCF7 mammary carcinoma cells, conditioned medium from TPA-differentiated/activated U937 cells suppressed pdcd4 mRNA.	Tetradecanoylphorbol Acetate	71-74	programmed cell death 4	Homo sapiens	122-127
23105093-6	2012	Both supershift and ChIP assays revealed the presence of the AP-1 component c-JUN at the PED/PEA-15 promoter upon 12-O-tetradecanoylphorbol-13-acetate stimulation of the cells.	Tetradecanoylphorbol Acetate	114-150	preimplantation embryo development	Mus musculus	89-92
23847772-2	2012	The plasmin-activating cascade, in which urokinase (uPA) and tissue-type (tPA) plasminogen activators convert plasminogen to the broad-spectrum protease plasmin, appears to serve a protective, Abeta-clearing, role in the central nervous system.	Tetradecanoylphorbol Acetate	74-77	plasminogen	Homo sapiens	4-11
20203291-4	2010	This binding was enhanced by exposing the cells to phorbol-12-myristate-13-acetate, an activator of protein kinase C and stimulator of mucin secretion.	Tetradecanoylphorbol Acetate	51-82	LOC100508689	Homo sapiens	135-140
23847772-2	2012	The plasmin-activating cascade, in which urokinase (uPA) and tissue-type (tPA) plasminogen activators convert plasminogen to the broad-spectrum protease plasmin, appears to serve a protective, Abeta-clearing, role in the central nervous system.	Tetradecanoylphorbol Acetate	74-77	plasminogen	Homo sapiens	79-86
20445555-5	2010	PKC-delta knockdown reduces TPA-activated involucrin promoter activity, nuclear activator protein-1 factor accumulation and binding to DNA, and cell morphology change.	Tetradecanoylphorbol Acetate	28-31	protein kinase C delta	Homo sapiens	0-9
22736020-9	2012	FOXP3+ mucosal CD4+ T cells from both IBD and control specimens were able to make IL-17A in vitro after phorbol myristate acetate (PMA) and ionomycin stimulation, but these cells did not preferentially express Deltaexon2.	Tetradecanoylphorbol Acetate	104-129	forkhead box P3	Homo sapiens	0-5
22736020-9	2012	FOXP3+ mucosal CD4+ T cells from both IBD and control specimens were able to make IL-17A in vitro after phorbol myristate acetate (PMA) and ionomycin stimulation, but these cells did not preferentially express Deltaexon2.	Tetradecanoylphorbol Acetate	131-134	forkhead box P3	Homo sapiens	0-5
21474293-2	2012	We hypothesized that minocycline induced MMP-2 and MMP-9 inhibition can be enhanced by aspirin (through its COX and tPA inhibitory action) and this combination can reduce cardiovascular dysfunction of diabetes.	Tetradecanoylphorbol Acetate	116-119	matrix metallopeptidase 2	Rattus norvegicus	41-46
22940786-5	2012	To test whether the cellular level of HA is             elevated by the induction of HDC in Jurkat cells treated with TPA, the peak corresponding             to authentic HA in the cell lysate was fractioned and its molecular weight determined             by matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight             mass spectrometry.	Tetradecanoylphorbol Acetate	118-121	histidine decarboxylase	Homo sapiens	85-88
22940786-6	2012	The results of this study show that the HA level is increased             by the induction of HDC expression by TPA in Jurkat cells.	Tetradecanoylphorbol Acetate	112-115	histidine decarboxylase	Homo sapiens	94-97
22827975-2	2012	Using the 12-dimethylbenz(alpha)anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA) two-stage model of skin carcinogenesis, we found that Emilin1(-/-) mice presented an accelerated formation, a higher incidence, and the development of a larger number of tumors compared with their wild-type littermates.	Tetradecanoylphorbol Acetate	43-79	elastin microfibril interfacer 1	Mus musculus	145-152
22977714-0	2012	Phorbol 12-Myristate 13-Acetate Induces MUC16 Expression via PKCdelta and p38 in Human Airway Epithelial Cells.	Tetradecanoylphorbol Acetate	0-31	protein kinase C delta	Homo sapiens	61-69
22977714-1	2012	OBJECTIVES: Phorbol 12-myristate 13-acetate (PMA) is widely used as a protein kinase C (PKC) activator, PKC is involved in the secretion of mucins.	Tetradecanoylphorbol Acetate	12-43	protein kinase C delta	Homo sapiens	88-91
22977714-1	2012	OBJECTIVES: Phorbol 12-myristate 13-acetate (PMA) is widely used as a protein kinase C (PKC) activator, PKC is involved in the secretion of mucins.	Tetradecanoylphorbol Acetate	12-43	protein kinase C delta	Homo sapiens	104-107
22977714-1	2012	OBJECTIVES: Phorbol 12-myristate 13-acetate (PMA) is widely used as a protein kinase C (PKC) activator, PKC is involved in the secretion of mucins.	Tetradecanoylphorbol Acetate	45-48	protein kinase C delta	Homo sapiens	88-91
22977714-1	2012	OBJECTIVES: Phorbol 12-myristate 13-acetate (PMA) is widely used as a protein kinase C (PKC) activator, PKC is involved in the secretion of mucins.	Tetradecanoylphorbol Acetate	45-48	protein kinase C delta	Homo sapiens	104-107
22609779-3	2012	The inhibitory effect of AAPE at 2mug/ml on MMP-2 activity was increased in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	92-117	matrix metallopeptidase 2	Homo sapiens	44-49
22609779-3	2012	The inhibitory effect of AAPE at 2mug/ml on MMP-2 activity was increased in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	119-122	matrix metallopeptidase 2	Homo sapiens	44-49
22488409-2	2012	Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	79-110	haptoglobin-related protein	Homo sapiens	21-24
22488409-2	2012	Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	112-115	haptoglobin-related protein	Homo sapiens	21-24
22710295-3	2012	AIM OF THE STUDY: The present study aims to investigate the anti-inflammatory effect of aqueous extract of Rhizoma Polygonati (ERP) in a mouse model of inflammation induced by 12-O-tetradecanoylphorbol-acetate (TPA).	Tetradecanoylphorbol Acetate	176-209	ELK3, member of ETS oncogene family	Mus musculus	127-130
22710295-3	2012	AIM OF THE STUDY: The present study aims to investigate the anti-inflammatory effect of aqueous extract of Rhizoma Polygonati (ERP) in a mouse model of inflammation induced by 12-O-tetradecanoylphorbol-acetate (TPA).	Tetradecanoylphorbol Acetate	211-214	ELK3, member of ETS oncogene family	Mus musculus	127-130
22710295-6	2012	RESULTS: The results showed that ERP significantly decreased the ear thickness and MPO activity in mouse model of inflammation induced by TPA.	Tetradecanoylphorbol Acetate	138-141	ELK3, member of ETS oncogene family	Mus musculus	33-36
22710295-8	2012	CONCLUSIONS: These results indicate that ERP has potential anti-inflammatory effect on TPA-induced inflammatory in mice, and the anti-inflammatory effect may be mediated, at least in part, by inhibiting the mRNA expression of a panel of inflammatory mediators including iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6.	Tetradecanoylphorbol Acetate	87-90	ELK3, member of ETS oncogene family	Mus musculus	41-44
22562304-0	2012	TPA-induced cell transformation provokes a complex formation between Pin1 and 90 kDa ribosomal protein S6 kinase 2.	Tetradecanoylphorbol Acetate	0-3	ribosomal protein S6 kinase A3	Homo sapiens	85-114
22614916-5	2012	Upregulated Rap1GAP in NB4 and HL-60 cells promoted             cell differentiation induced by ATRA or TPA compared to the empty vector control             cells.	Tetradecanoylphorbol Acetate	104-107	RAP1 GTPase activating protein	Homo sapiens	12-19
22732221-1	2012	We examined that the protective effects of ANX1 on 12-O-tetradecanoylphorbol- 13-acetate (TPA)-induced skin inflammation in animal models using a Tat-ANX1 protein.	Tetradecanoylphorbol Acetate	51-88	annexin A1	Mus musculus	43-47
22770404-9	2012	Similarly, when ADAM10 was suppressed by short hairpin RNA, CD16b shedding was decreased after stimulation with ionomycin; when ADAM17 was suppressed by short hairpin RNA, CD16b shedding was decreased after stimulation with PMA.	Tetradecanoylphorbol Acetate	224-227	Fc gamma receptor IIIb	Homo sapiens	172-177
21480396-0	2012	Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase Cepsilon with Stat3 involve integration with ERK1/2.	Tetradecanoylphorbol Acetate	26-62	mitogen-activated protein kinase 3	Mus musculus	162-168
21480396-8	2012	Both UVR and TPA treatment stimulated PKCepsilon-Stat3 interaction, Stat3Ser727 phosphorylation and Stat3-regulated gene COX-2 expression.	Tetradecanoylphorbol Acetate	13-16	protein kinase C, epsilon	Mus musculus	38-48
22181070-3	2012	Pretreatment with phloretin on the dorsal skin of mice inhibited TPA-induced COX-2 expression in a dose-dependent manner.	Tetradecanoylphorbol Acetate	65-68	prostaglandin-endoperoxide synthase 2	Mus musculus	77-82
22181070-6	2012	In addition, phloretin inhibited the phosphorylation as well as the catalytic activity of extracellular signal-regulated kinase (ERK), which was previously found to activate NF-kappaB and induce COX-2 expression in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	215-218	prostaglandin-endoperoxide synthase 2	Mus musculus	195-200
22052014-5	2012	We show that, in response to PMA, PKCdelta, a member of novel PKC isozymes, and MEK-ERK1/2 pathway of mitogen-activated protein kinases stimulate the NHE2 expression in C2BBe1 intestinal epithelial cells.	Tetradecanoylphorbol Acetate	29-32	protein kinase C delta	Homo sapiens	34-42
22052014-5	2012	We show that, in response to PMA, PKCdelta, a member of novel PKC isozymes, and MEK-ERK1/2 pathway of mitogen-activated protein kinases stimulate the NHE2 expression in C2BBe1 intestinal epithelial cells.	Tetradecanoylphorbol Acetate	29-32	protein kinase C delta	Homo sapiens	34-37
22052014-6	2012	PMA rapidly and transiently induced activation of PKCdelta.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	50-58
22052014-8	2012	In addition, blockade of PKCdelta by rottlerin, a PKCdelta-specific inhibitor, and ERK1/2 by U0126, a MEK-ERK inhibitor, abrogated PMA-induced Egr-1 expression.	Tetradecanoylphorbol Acetate	131-134	protein kinase C delta	Homo sapiens	25-33
22052014-8	2012	In addition, blockade of PKCdelta by rottlerin, a PKCdelta-specific inhibitor, and ERK1/2 by U0126, a MEK-ERK inhibitor, abrogated PMA-induced Egr-1 expression.	Tetradecanoylphorbol Acetate	131-134	protein kinase C delta	Homo sapiens	50-58
23092297-10	2012	The cell death sensitising effect of atorvastatin was apparently mediated by down modulation of PKCbeta activity, because it was reproduced by the specific PKCbeta inhibitor LY317615 and prevented by the PKC activator phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	218-249	protein kinase C beta	Homo sapiens	96-103
23092297-10	2012	The cell death sensitising effect of atorvastatin was apparently mediated by down modulation of PKCbeta activity, because it was reproduced by the specific PKCbeta inhibitor LY317615 and prevented by the PKC activator phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	218-249	protein kinase C beta	Homo sapiens	96-99
23092297-10	2012	The cell death sensitising effect of atorvastatin was apparently mediated by down modulation of PKCbeta activity, because it was reproduced by the specific PKCbeta inhibitor LY317615 and prevented by the PKC activator phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	251-254	protein kinase C beta	Homo sapiens	96-103
23092297-10	2012	The cell death sensitising effect of atorvastatin was apparently mediated by down modulation of PKCbeta activity, because it was reproduced by the specific PKCbeta inhibitor LY317615 and prevented by the PKC activator phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	251-254	protein kinase C beta	Homo sapiens	96-99
22685674-3	2012	We have found that TPA-induced differentiation of ML-1 cells was accompanied by the upregulation of TLR1, TLR2, TLR4, and CD14 expression at both the mRNA and protein levels.	Tetradecanoylphorbol Acetate	19-22	CD14 molecule	Homo sapiens	122-126
22011436-8	2012	Moreover, norepinephrine release and AT1 receptor expression were increased by the nitric oxide (NO) synthase inhibitor N(G)-methyl-L-arginine and the protein kinase C activator phorbol myristate acetate.	Tetradecanoylphorbol Acetate	178-203	angiotensin II receptor, type 1a	Rattus norvegicus	37-40
22879913-3	2012	Although it has been widely noted that interferon-beta (IFNbeta) downregulates both the basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression at the transcriptional level, the molecular mechanism of this repression is poorly understood.	Tetradecanoylphorbol Acetate	98-129	interferon beta 1	Homo sapiens	39-54
21992606-9	2011	Virus could be recovered from CCL19-treated infected CD4+ T-cells following mitogen stimulation (with PHA and phorbyl myristate acetate (PMA)) as well as TNFalpha, IL-7, prostratin and vorinostat.	Tetradecanoylphorbol Acetate	137-140	C-C motif chemokine ligand 19	Homo sapiens	30-35
22879913-3	2012	Although it has been widely noted that interferon-beta (IFNbeta) downregulates both the basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression at the transcriptional level, the molecular mechanism of this repression is poorly understood.	Tetradecanoylphorbol Acetate	98-129	interferon beta 1	Homo sapiens	56-63
22879913-3	2012	Although it has been widely noted that interferon-beta (IFNbeta) downregulates both the basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression at the transcriptional level, the molecular mechanism of this repression is poorly understood.	Tetradecanoylphorbol Acetate	131-134	interferon beta 1	Homo sapiens	39-54
22879913-3	2012	Although it has been widely noted that interferon-beta (IFNbeta) downregulates both the basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression at the transcriptional level, the molecular mechanism of this repression is poorly understood.	Tetradecanoylphorbol Acetate	131-134	interferon beta 1	Homo sapiens	56-63
21832145-7	2011	CLDN18 variant 2 mRNA was expressed and was similarly upregulated by phorbol 12-myristate 13-acetate (PMA) treatment in pancreatic cancer cell lines and in a gastric cancer cell line.	Tetradecanoylphorbol Acetate	69-100	claudin 18	Homo sapiens	0-6
22870256-5	2012	This induction of Plk2 expression was mimicked by both forskolin and phorbol 12 myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	69-100	polo-like kinase 2	Rattus norvegicus	18-22
21832145-7	2011	CLDN18 variant 2 mRNA was expressed and was similarly upregulated by phorbol 12-myristate 13-acetate (PMA) treatment in pancreatic cancer cell lines and in a gastric cancer cell line.	Tetradecanoylphorbol Acetate	102-105	claudin 18	Homo sapiens	0-6
21730054-8	2011	Histamine or PMA stimulation resulted in PKCdelta phosphorylation at Tyr(311) and Thr(505).	Tetradecanoylphorbol Acetate	13-16	protein kinase C delta	Homo sapiens	41-49
21730054-11	2011	Histamine or PMA caused translocation PKCdelta from the cytosol to the Golgi.	Tetradecanoylphorbol Acetate	13-16	protein kinase C delta	Homo sapiens	38-46
22870256-5	2012	This induction of Plk2 expression was mimicked by both forskolin and phorbol 12 myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	102-105	polo-like kinase 2	Rattus norvegicus	18-22
23209876-6	2012	Ku86 was responsible for DNA binding and poly(ADP-ribosyl)ated in response to phorbol-12-myristate-13-acetate stimulation, inducing its dissociation from region B1 that is crucial for promoter activity.	Tetradecanoylphorbol Acetate	78-109	X-ray repair cross complementing 5	Homo sapiens	0-4
21468691-3	2011	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) gradually up-regulated the expression of ASK1 mRNA and protein, and subsequently enhanced its catalytic activity in MCF-7 cells.	Tetradecanoylphorbol Acetate	23-54	protein kinase C delta	Homo sapiens	14-17
21468691-3	2011	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) gradually up-regulated the expression of ASK1 mRNA and protein, and subsequently enhanced its catalytic activity in MCF-7 cells.	Tetradecanoylphorbol Acetate	56-59	protein kinase C delta	Homo sapiens	14-17
21842414-6	2011	On the other hand, TPA-induced phosphorylation of integrin signaling components including focal adhesion kinase (FAK), Src (Tyr416) and paxillin (Tyr31 and Ser178) can be prevented by PKC inhibitor Bisindolylmaleimides (BIS) and antioxidant dithiotheritol (DTT).	Tetradecanoylphorbol Acetate	19-22	protein tyrosine kinase 2	Homo sapiens	90-111
21804018-5	2011	Rottlerin, a PKCdelta-specific inhibitor, significantly reduced PMA-induced IL-1beta production as well as CD11b, TLR2 expression, and IRAK1-JNK activation.	Tetradecanoylphorbol Acetate	64-67	protein kinase C delta	Homo sapiens	13-21
21842414-6	2011	On the other hand, TPA-induced phosphorylation of integrin signaling components including focal adhesion kinase (FAK), Src (Tyr416) and paxillin (Tyr31 and Ser178) can be prevented by PKC inhibitor Bisindolylmaleimides (BIS) and antioxidant dithiotheritol (DTT).	Tetradecanoylphorbol Acetate	19-22	protein tyrosine kinase 2	Homo sapiens	113-116
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	43-79	superoxide dismutase 2	Homo sapiens	94-124
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	43-79	superoxide dismutase 2	Homo sapiens	126-131
21871883-5	2011	In this study we investigated the effect of A771726, the active metabolite of leflunomide, on expression of CD147 and on the gelatinolytic activity of MMP-2 and MMP-9 in phorbol myristate acetate (PMA) differentiated THP-1 cells.	Tetradecanoylphorbol Acetate	170-195	matrix metallopeptidase 2	Homo sapiens	151-156
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	81-84	superoxide dismutase 2	Homo sapiens	94-124
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	81-84	superoxide dismutase 2	Homo sapiens	126-131
21705328-1	2011	12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors.	Tetradecanoylphorbol Acetate	0-36	superoxide dismutase 2	Homo sapiens	104-134
21705328-1	2011	12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors.	Tetradecanoylphorbol Acetate	0-36	superoxide dismutase 2	Homo sapiens	136-141
21705328-1	2011	12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors.	Tetradecanoylphorbol Acetate	38-41	superoxide dismutase 2	Homo sapiens	104-134
21705328-1	2011	12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors.	Tetradecanoylphorbol Acetate	38-41	superoxide dismutase 2	Homo sapiens	136-141
21705328-2	2011	In this study, we showed that MnSOD protein expression was elevated in response to TPA or TNF-alpha, but not to hydrogen peroxide treatment.	Tetradecanoylphorbol Acetate	83-86	superoxide dismutase 2	Homo sapiens	30-35
21705328-4	2011	Small interfering RNA (siRNA) experiments indicated that knocking down the NADPH oxidase components e.g. Rac1, p22(phox), p67(phox), and NOXO1 in A549 cells impaired TPA-induced MnSOD expression.	Tetradecanoylphorbol Acetate	166-169	superoxide dismutase 2	Homo sapiens	178-183
21705328-5	2011	To identify the PKC isozyme involved, we used a sod2 gene response reporter plasmid, pSODLUC-3340-I2E-C, capable of sensing the effect of TNF-alpha and TPA, to monitor the effects of PKC isozyme-specific inhibitors and siRNA-induced knockdown of specific PKC isozyme.	Tetradecanoylphorbol Acetate	152-155	superoxide dismutase 2	Homo sapiens	48-52
21903576-5	2011	SSeCKS-null mouse embryo fibroblasts displayed increased relative basal and phorbol ester (phorbol 12-myristate 13-acetate)-induced PKC activity but were defective in phorbol 12-myristate 13-acetate-induced actin cytoskeletal reorganization and cell shape change; these responses could be rescued by the forced expression of full-length SSeCKS but not by an SSeCKS variant deleted of its PKC-binding domains.	Tetradecanoylphorbol Acetate	91-122	A kinase (PRKA) anchor protein (gravin) 12	Mus musculus	0-6
21705328-6	2011	Our data indicate that TPA-induced MnSOD expression was independent of p53 and most likely mediated by PKC-alpha-, and -epsilon-dependent signaling pathways.	Tetradecanoylphorbol Acetate	23-26	superoxide dismutase 2	Homo sapiens	35-40
21705328-7	2011	Furthermore, siRNA-induced knock-down of CREB and Forkhead box class O (FOXO) 3a led to a reduction in TPA-induced MnSOD gene expression.	Tetradecanoylphorbol Acetate	103-106	superoxide dismutase 2	Homo sapiens	115-120
21705328-8	2011	Together, our results revealed that TPA up-regulates, in part, two PKC-dependent transcriptional pathways to induce MnSOD expression.	Tetradecanoylphorbol Acetate	36-39	superoxide dismutase 2	Homo sapiens	116-121
21903576-5	2011	SSeCKS-null mouse embryo fibroblasts displayed increased relative basal and phorbol ester (phorbol 12-myristate 13-acetate)-induced PKC activity but were defective in phorbol 12-myristate 13-acetate-induced actin cytoskeletal reorganization and cell shape change; these responses could be rescued by the forced expression of full-length SSeCKS but not by an SSeCKS variant deleted of its PKC-binding domains.	Tetradecanoylphorbol Acetate	167-198	A kinase (PRKA) anchor protein (gravin) 12	Mus musculus	0-6
21871959-7	2011	The results showed that the treatment of c-CA and t-CA dose-dependently reduced the PMA-induced MMP-2 and -9 activities but without significant effect on the adhesive activity of cells.	Tetradecanoylphorbol Acetate	84-87	matrix metallopeptidase 2	Homo sapiens	96-108
21647562-4	2011	Tumoral promyelocytes in which Vav1 was negatively modulated were induced to differentiate into monocytes/macrophages with phorbol-12-myristate-13-acetate (PMA) and monitored for their maturation-related properties.	Tetradecanoylphorbol Acetate	156-159	vav guanine nucleotide exchange factor 1	Homo sapiens	31-35
21734098-9	2011	In addition, AGE-BSA or suppression of NRP1 both reduced the phosphorylation of focal adhesion kinase (FAK) and Erk1/2 in PMA-stimulated differentiated podocytes.	Tetradecanoylphorbol Acetate	122-125	mitogen-activated protein kinase 3	Mus musculus	112-118
21647562-6	2011	Confocal analysis revealed that Vav1 may synergize with actin in modulating nuclear morphology of PMA-treated adherent cells.	Tetradecanoylphorbol Acetate	98-101	vav guanine nucleotide exchange factor 1	Homo sapiens	32-36
21939515-1	2011	Phorbol ester (TPA) treatment of human U937 myeloid leukemia cells is associated with increasing adherence and monocyte-like maturation whereby the role of beta2 integrin-mediated attachment for subsequent growth properties and the differentiation program remains unclear.	Tetradecanoylphorbol Acetate	15-18	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	156-161
21558273-6	2011	PMA-induced inhibition of proliferation was attenuated in C/EBPbeta-short cells.	Tetradecanoylphorbol Acetate	0-3	CCAAT enhancer binding protein beta	Homo sapiens	58-67
21646541-3	2011	In response to the 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate mouse skin carcinogenesis protocol, miR-21-null mice showed a significant reduction in papilloma formation compared with wild-type mice.	Tetradecanoylphorbol Acetate	57-93	microRNA 21a	Mus musculus	130-136
21939515-6	2011	Western blot analysis revealed differences in the expression levels and altered phosphorylation patterns of Pyk-2, pp60src and p42/p44 MAP kinases between pMTH1-U937 and asCD11b-U937 following TPA exposure which was also substantiated by Pyk-2 immunoprecipitation.	Tetradecanoylphorbol Acetate	193-196	interferon induced protein 44	Homo sapiens	131-134
21467074-5	2011	Phorbol 12-myristate 13-acetate (PMA), which stimulates PKCs, induced p66shc phosphorylation and this was inhibited by a selective PKCbetaII inhibitor.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, beta	Mus musculus	131-140
21478148-6	2011	12-O-tetradecanoylphorbol-13-acetate activation of p42/p44 MAPK drives Bim ubiquitination in mouse embryonic fibroblast cells and is associated with an increased interaction between TRIM2 and Bim.	Tetradecanoylphorbol Acetate	0-36	erythrocyte membrane protein band 4.2	Mus musculus	51-54
21478148-6	2011	12-O-tetradecanoylphorbol-13-acetate activation of p42/p44 MAPK drives Bim ubiquitination in mouse embryonic fibroblast cells and is associated with an increased interaction between TRIM2 and Bim.	Tetradecanoylphorbol Acetate	0-36	mitogen-activated protein kinase 3	Mus musculus	55-63
21478148-6	2011	12-O-tetradecanoylphorbol-13-acetate activation of p42/p44 MAPK drives Bim ubiquitination in mouse embryonic fibroblast cells and is associated with an increased interaction between TRIM2 and Bim.	Tetradecanoylphorbol Acetate	0-36	tripartite motif-containing 2	Mus musculus	182-187
21467074-5	2011	Phorbol 12-myristate 13-acetate (PMA), which stimulates PKCs, induced p66shc phosphorylation and this was inhibited by a selective PKCbetaII inhibitor.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, beta	Mus musculus	131-140
21631112-5	2011	Similarly, in the murine ear edema model, 12-O-tetradecanoylphorbol-13-acetate-induced inflammation was inhibited by mogrosides by down-regulating COX-2 and IL-6 and up-regulating PARP1, BCL2l1, TRP53, MAPK9, and PPARdelta gene expression.	Tetradecanoylphorbol Acetate	42-78	cytochrome c oxidase II, mitochondrial	Mus musculus	147-152
21042803-8	2011	Western blot analyses revealed that EC and EGCG prevented down-regulation of Cx26 and Cx43 proteins in HaCaT cells treated with PMA.	Tetradecanoylphorbol Acetate	128-131	gap junction protein alpha 1	Homo sapiens	86-90
21042803-9	2011	Immunocytochemistry showed decreased expression and abnormal location of Cx26 and Cx43 in HaCaT cells when treated with PMA, and EC and EGCG inhibited its effect.	Tetradecanoylphorbol Acetate	120-123	gap junction protein alpha 1	Homo sapiens	82-86
21542090-1	2011	Phorbol 12-myristate 13-acetate (PMA) and bryostatin 1 are both potent protein kinase C (PKC) activators.	Tetradecanoylphorbol Acetate	0-31	protein kinase C delta	Homo sapiens	89-92
21542090-1	2011	Phorbol 12-myristate 13-acetate (PMA) and bryostatin 1 are both potent protein kinase C (PKC) activators.	Tetradecanoylphorbol Acetate	33-36	protein kinase C delta	Homo sapiens	89-92
21631112-5	2011	Similarly, in the murine ear edema model, 12-O-tetradecanoylphorbol-13-acetate-induced inflammation was inhibited by mogrosides by down-regulating COX-2 and IL-6 and up-regulating PARP1, BCL2l1, TRP53, MAPK9, and PPARdelta gene expression.	Tetradecanoylphorbol Acetate	42-78	BCL2-like 1	Mus musculus	187-193
21657219-4	2011	The first oxidation potential is localized to the TPA unit when, for example, EDGs are placed at R(1) with EWGs at R(2) (e.g., the TPA( +)/TPA(0) and Ru(III)/Ru(II) redox couples appear at +0.98 and +1.27 V vs NHE, respectively, when R(1) = -OMe and R(2) = -CF(3)).	Tetradecanoylphorbol Acetate	50-53	solute carrier family 9 member C1	Homo sapiens	210-213
21657219-5	2011	This situation is reversed when R(3) = EDG and R(1) = -H: TPA-based and metal-centered oxidation waves occur at +1.20 and +1.11 V vs NHE, respectively.	Tetradecanoylphorbol Acetate	58-61	solute carrier family 9 member C1	Homo sapiens	133-136
21336470-0	2011	Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	93-129	mitogen-activated protein kinase 14	Mus musculus	8-11
21733825-2	2011	During the process of skin tumor promotion induced by treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), activation of epidermal Akt occurs as well as several downstream effectors of Akt, including the activation of mTORC1.	Tetradecanoylphorbol Acetate	125-128	CREB regulated transcription coactivator 1	Mus musculus	242-248
21336470-9	2011	Although the p38alpha isoform is important, our data also demonstrate an important role of the p38beta and/or delta isoforms in the regulation of TPA-induced skin inflammation.	Tetradecanoylphorbol Acetate	146-149	mitogen-activated protein kinase 14	Mus musculus	13-21
21733825-4	2011	Rapamycin blocked TPA-induced activation of mTORC1 as well as several downstream targets.	Tetradecanoylphorbol Acetate	18-21	CREB regulated transcription coactivator 1	Mus musculus	44-50
21191110-7	2011	Also, supplementation with phorbol 12-myristate 13-acetate (PMA) stimulated IFNT mRNA levels to the same extent as with FGF2.	Tetradecanoylphorbol Acetate	27-58	interferon tau-2	Bos taurus	76-80
21381080-2	2011	The stomach isoform of Cldn18, Cldn18a2 is regulated via a PKC/MAPK/AP-1-dependent pathway in PKC activator 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated gastric cancer cells.	Tetradecanoylphorbol Acetate	108-144	claudin 18	Homo sapiens	23-29
21191110-7	2011	Also, supplementation with phorbol 12-myristate 13-acetate (PMA) stimulated IFNT mRNA levels to the same extent as with FGF2.	Tetradecanoylphorbol Acetate	60-63	interferon tau-2	Bos taurus	76-80
21381080-2	2011	The stomach isoform of Cldn18, Cldn18a2 is regulated via a PKC/MAPK/AP-1-dependent pathway in PKC activator 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated gastric cancer cells.	Tetradecanoylphorbol Acetate	146-149	claudin 18	Homo sapiens	23-29
21381080-5	2011	In all human pancreatic cancer cell lines and hTERT-HPDE cells, Cldn18 mRNA indicated as Cldn18a2 was markedly induced by TPA and in well- or moderately differentiated human pancreatic cancer cells HPAF-II and HPAC and hTERT-HPDE cells, the protein was also strongly increased.	Tetradecanoylphorbol Acetate	122-125	claudin 18	Homo sapiens	64-70
21381080-6	2011	The upregulation of Cldn18 by TPA in human pancreatic cancer cell lines was prevented by inhibitors of PKCdelta, PKCepsilon, and PKCalpha, whereas the upregulation of Cldn18 by TPA in hTERT-HPDE cells was prevented by inhibitors of PKCdelta, PKCtheta, and PKCalpha.	Tetradecanoylphorbol Acetate	30-33	claudin 18	Homo sapiens	20-26
21381080-6	2011	The upregulation of Cldn18 by TPA in human pancreatic cancer cell lines was prevented by inhibitors of PKCdelta, PKCepsilon, and PKCalpha, whereas the upregulation of Cldn18 by TPA in hTERT-HPDE cells was prevented by inhibitors of PKCdelta, PKCtheta, and PKCalpha.	Tetradecanoylphorbol Acetate	30-33	protein kinase C delta	Homo sapiens	103-111
21523377-8	2011	RESULTS: In HCEC culture medium, sIL-6R release was increased significantly (P &lt; 0.01) by adding PMA and this increased release of sIL-6R was inhibited significantly by adding TAPI-1, indicating the participation of ectodomain shedding in sIL-6R production.	Tetradecanoylphorbol Acetate	100-103	STIL centriolar assembly protein	Homo sapiens	33-36
21381080-6	2011	The upregulation of Cldn18 by TPA in human pancreatic cancer cell lines was prevented by inhibitors of PKCdelta, PKCepsilon, and PKCalpha, whereas the upregulation of Cldn18 by TPA in hTERT-HPDE cells was prevented by inhibitors of PKCdelta, PKCtheta, and PKCalpha.	Tetradecanoylphorbol Acetate	30-33	protein kinase C delta	Homo sapiens	232-240
21089054-0	2011	Acteoside inhibits PMA-induced matrix metalloproteinase-9 expression via CaMK/ERK- and JNK/NF-kappaB-dependent signaling.	Tetradecanoylphorbol Acetate	19-22	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	73-77
21612443-0	2011	Neutrophil gelatinase-associated lipocalin in gastric carcinoma cells and its induction by TPA are controlled by C/EBPbeta.	Tetradecanoylphorbol Acetate	91-94	CCAAT enhancer binding protein beta	Homo sapiens	113-122
21295103-5	2011	The mechanism revealed that wogonin significantly inhibited the expression and activity of both endogenous and phorbol-12-myristate-13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) potentially associating with the suppression of translocation of protein kinase C (PKC) delta and phosphorylation of extracellular signal-regulated kinase (ERK1/2).	Tetradecanoylphorbol Acetate	111-142	protein kinase C delta	Homo sapiens	257-285
21295103-5	2011	The mechanism revealed that wogonin significantly inhibited the expression and activity of both endogenous and phorbol-12-myristate-13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) potentially associating with the suppression of translocation of protein kinase C (PKC) delta and phosphorylation of extracellular signal-regulated kinase (ERK1/2).	Tetradecanoylphorbol Acetate	144-147	protein kinase C delta	Homo sapiens	257-285
21612443-8	2011	We identified the -110 to -79 sequence segment upstream from the transcription initiation site of NGAL as a TPA responsive element (TRE) and confirmed that C/EBPbeta was able to bind to the -87 to -79 segment.	Tetradecanoylphorbol Acetate	108-111	CCAAT enhancer binding protein beta	Homo sapiens	156-165
21612443-10	2011	These results suggest that NGAL is overexpressed in gastric cancer, the binding of C/EBPbeta to the TRE of its gene promoter mediates its TPA-induced overexpression in gastric carcinoma cells.	Tetradecanoylphorbol Acetate	138-141	CCAAT enhancer binding protein beta	Homo sapiens	83-92
21216846-4	2011	p-HPEA-EDA inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation of extracellular signal-regulated kinases 1/2 and p90RSK in JB6 Cl41 cells, resulting in the inhibition of cell proliferation, activator protein-1 transactivation and cell transformation promoted by TPA.	Tetradecanoylphorbol Acetate	21-57	ectodysplasin A	Homo sapiens	7-10
21557328-7	2011	TPA as a cotreatment did not inhibit TGFalpha-stimulated ERK oscillations but qualitatively altered TGFalpha-dependent ERK oscillation characteristics (amplitude, time-period).	Tetradecanoylphorbol Acetate	0-3	transforming growth factor alpha	Homo sapiens	100-108
21217772-5	2011	In Jurkat leukaemic T cells as well as in primary human T cells, tetradecanoylphorbolacetate/ionomycin- and CD3/CD28-induced RelB degradation were impaired by a GSK-3beta-specific pharmacological inhibitor, an ectopically expressed dominant-negative GSK-3beta mutant and by small-interfering RNA-mediated silencing of GSK-3beta expression.	Tetradecanoylphorbol Acetate	65-92	glycogen synthase kinase 3 beta	Homo sapiens	161-170
21346238-5	2011	Treatment with anti-IL-12/23p40 or anti-IL-23p19 Abs greatly inhibited 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia in the ears of K5.Stat3C mice, whereas the inhibitory effect of an anti-IL-17A Ab was relatively less prominent.	Tetradecanoylphorbol Acetate	71-107	interleukin 23, alpha subunit p19	Mus musculus	40-48
21292826-6	2011	The SRF site alone is sufficient for induction by GnRH, whereas induction by 12-tetradecanoylphorbol-13-acetate (TPA) requires both the ELK1 and SRF sites.	Tetradecanoylphorbol Acetate	77-111	serum response factor	Mus musculus	145-148
21292288-3	2011	BSL also potently inhibited the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced protein levels of nitrotyrosine and COX-2 in mouse skin with dermatitis.	Tetradecanoylphorbol Acetate	32-68	prostaglandin-endoperoxide synthase 2	Mus musculus	119-124
21292288-3	2011	BSL also potently inhibited the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced protein levels of nitrotyrosine and COX-2 in mouse skin with dermatitis.	Tetradecanoylphorbol Acetate	70-73	prostaglandin-endoperoxide synthase 2	Mus musculus	119-124
21217772-5	2011	In Jurkat leukaemic T cells as well as in primary human T cells, tetradecanoylphorbolacetate/ionomycin- and CD3/CD28-induced RelB degradation were impaired by a GSK-3beta-specific pharmacological inhibitor, an ectopically expressed dominant-negative GSK-3beta mutant and by small-interfering RNA-mediated silencing of GSK-3beta expression.	Tetradecanoylphorbol Acetate	65-92	glycogen synthase kinase 3 beta	Homo sapiens	250-259
21217772-5	2011	In Jurkat leukaemic T cells as well as in primary human T cells, tetradecanoylphorbolacetate/ionomycin- and CD3/CD28-induced RelB degradation were impaired by a GSK-3beta-specific pharmacological inhibitor, an ectopically expressed dominant-negative GSK-3beta mutant and by small-interfering RNA-mediated silencing of GSK-3beta expression.	Tetradecanoylphorbol Acetate	65-92	glycogen synthase kinase 3 beta	Homo sapiens	250-259
21499124-6	2011	Binding activity to ULBP1 promoter region of AP-2alpha, which suggested as suppressor of expression of ULBP1, was decreased by treatment with EGFR inhibitors, and restored by pretreatment with phorbol 12-myristate 13-acetate in A549 and SW-900.	Tetradecanoylphorbol Acetate	193-224	UL16 binding protein 1	Homo sapiens	103-108
21300803-8	2011	Furthermore, we showed that PMA can induce the proximal (GT/AC)(n) repeat sequence to convert to the Z-DNA structure in the SLC11A1 gene promoter, and depletion of BRG1 resulted in a significant decrease of Z-DNA formation.	Tetradecanoylphorbol Acetate	28-31	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	164-168
21288900-8	2011	Using protease inhibitors, ionomycin and phorbol myristate acetate stimulation, small interfering RNA knockdown, and site-directed mutagenesis, we found that ADAM10 was primarily responsible for shedding corin in its juxtamembrane region to release the ~180-kDa fragment, corresponding to the near-entire extracellular region.	Tetradecanoylphorbol Acetate	41-66	ADAM metallopeptidase domain 10	Homo sapiens	158-164
21216846-4	2011	p-HPEA-EDA inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation of extracellular signal-regulated kinases 1/2 and p90RSK in JB6 Cl41 cells, resulting in the inhibition of cell proliferation, activator protein-1 transactivation and cell transformation promoted by TPA.	Tetradecanoylphorbol Acetate	59-62	ectodysplasin A	Homo sapiens	7-10
21216846-4	2011	p-HPEA-EDA inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation of extracellular signal-regulated kinases 1/2 and p90RSK in JB6 Cl41 cells, resulting in the inhibition of cell proliferation, activator protein-1 transactivation and cell transformation promoted by TPA.	Tetradecanoylphorbol Acetate	287-290	ectodysplasin A	Homo sapiens	7-10
21262967-3	2011	Generation of reactive oxygen species (ROS) in response to angiotensin II (Ang II) or phorbol 12-myristate 13-acetate was markedly reduced in perfused lungs and isolated PMVEC from Prdx6 null mice.	Tetradecanoylphorbol Acetate	86-117	peroxiredoxin 6	Mus musculus	181-186
21238464-6	2011	KEY FINDINGS: It was observed that resveratrol exhibited not only antioxidant effects on lipid peroxidation and DNA oxidation but also inhibitory effects on the expression of MMP-2 and 9 in HT1080 cells stimulated with either phorbol myristate acetate or phenazine methosulfate.	Tetradecanoylphorbol Acetate	226-251	matrix metallopeptidase 2	Homo sapiens	175-180
21133648-9	2011	Important, IRF5 was upregulated by the protein kinase C agonist 12-O-tetradecanoyl-phorbol-13-acetate in BCBL1 PEL cells and interaction with vIRF3 was observed at the endogenous p21 promoter in response to 12-O-tetradecanoyl-phorbol-13-acetate, suggesting that these 2 proteins cooperate in the regulation of lytic cycle-induced G1 arrest, which is an important early step for the reactivation of KSHV.	Tetradecanoylphorbol Acetate	64-101	interferon regulatory factor 5	Homo sapiens	11-15
21133891-4	2011	EXPERIMENTAL APPROACH: COS-7 cells in which OATP1A2 was overexpressed were treated with the PKC-specific activator (phorbol 12-myristate 13-acetate; PMA) and the PKC-specific inhibitor (Go6976).	Tetradecanoylphorbol Acetate	116-147	solute carrier organic anion transporter family member 1A2	Homo sapiens	44-51
21133891-4	2011	EXPERIMENTAL APPROACH: COS-7 cells in which OATP1A2 was overexpressed were treated with the PKC-specific activator (phorbol 12-myristate 13-acetate; PMA) and the PKC-specific inhibitor (Go6976).	Tetradecanoylphorbol Acetate	149-152	solute carrier organic anion transporter family member 1A2	Homo sapiens	44-51
21133891-7	2011	PMA (0.1 microM) decreased the V(max) of oestrone-3-sulphate uptake and decreased the cell surface expression of OATP1A2 immunoreactive protein; these effects of PMA were prevented by the PKC specific inhibitor Go6976.	Tetradecanoylphorbol Acetate	0-3	solute carrier organic anion transporter family member 1A2	Homo sapiens	113-120
21133891-7	2011	PMA (0.1 microM) decreased the V(max) of oestrone-3-sulphate uptake and decreased the cell surface expression of OATP1A2 immunoreactive protein; these effects of PMA were prevented by the PKC specific inhibitor Go6976.	Tetradecanoylphorbol Acetate	162-165	solute carrier organic anion transporter family member 1A2	Homo sapiens	113-120
21133648-9	2011	Important, IRF5 was upregulated by the protein kinase C agonist 12-O-tetradecanoyl-phorbol-13-acetate in BCBL1 PEL cells and interaction with vIRF3 was observed at the endogenous p21 promoter in response to 12-O-tetradecanoyl-phorbol-13-acetate, suggesting that these 2 proteins cooperate in the regulation of lytic cycle-induced G1 arrest, which is an important early step for the reactivation of KSHV.	Tetradecanoylphorbol Acetate	207-244	interferon regulatory factor 5	Homo sapiens	11-15
21303260-3	2011	Topical application of 5 nmol of TPA to mouse ears markedly increased the ear weight, expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein, and phosphorylation of the inhibitor of kappaB (IkappaB) alpha, AKT, and extracellular signal-regulated protein kinase (ERK) 1/2 and reduced IkappaBalpha protein levels.	Tetradecanoylphorbol Acetate	33-36	cytochrome c oxidase II, mitochondrial	Mus musculus	147-169
20885446-6	2011	Further analysis suggests that hVps34/14-3-3 association is a phorbol-12-myristate-13-acetate-dependent phosphorylated mechanism promoting a strong inhibition of the hVps34 lipid kinase activity, proteins kinase C being the likely kinase involved in phosphorylation and 14-3-3 binding of hVps34 under physiological conditions.	Tetradecanoylphorbol Acetate	62-93	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	31-37
21314333-4	2011	The myeloperoxidase activity in TPA-treated skin from MSK1/2 knockout mice was significantly elevated compared with wild-type mice.	Tetradecanoylphorbol Acetate	32-35	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	54-60
20885446-6	2011	Further analysis suggests that hVps34/14-3-3 association is a phorbol-12-myristate-13-acetate-dependent phosphorylated mechanism promoting a strong inhibition of the hVps34 lipid kinase activity, proteins kinase C being the likely kinase involved in phosphorylation and 14-3-3 binding of hVps34 under physiological conditions.	Tetradecanoylphorbol Acetate	62-93	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	166-172
21282553-10	2011	Furthermore, protein kinase C activation with phorbol 12-myristate 13-acetate increased renin expression to the same extent as Ang II.	Tetradecanoylphorbol Acetate	46-77	renin	Rattus norvegicus	88-93
20885446-6	2011	Further analysis suggests that hVps34/14-3-3 association is a phorbol-12-myristate-13-acetate-dependent phosphorylated mechanism promoting a strong inhibition of the hVps34 lipid kinase activity, proteins kinase C being the likely kinase involved in phosphorylation and 14-3-3 binding of hVps34 under physiological conditions.	Tetradecanoylphorbol Acetate	62-93	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	166-172
21068752-5	2011	Short-term phorbol-12-myristate-13-acetate (TPA) treatment or inhibition of phosphatidylinositol-3 kinase signaling in proliferative keratinocytes suppressed TRIP transcription.	Tetradecanoylphorbol Acetate	11-42	TRAF interacting protein	Homo sapiens	158-162
20687122-8	2011	The gap junction connexin43 likely involved in the communication between the two cell types, because 12-O-tetradecanoylphorbol 13-acetate (TPA) could partially block cellular crosstalk.	Tetradecanoylphorbol Acetate	101-137	gap junction protein alpha 1	Homo sapiens	17-27
21068752-5	2011	Short-term phorbol-12-myristate-13-acetate (TPA) treatment or inhibition of phosphatidylinositol-3 kinase signaling in proliferative keratinocytes suppressed TRIP transcription.	Tetradecanoylphorbol Acetate	44-47	TRAF interacting protein	Homo sapiens	158-162
20687122-8	2011	The gap junction connexin43 likely involved in the communication between the two cell types, because 12-O-tetradecanoylphorbol 13-acetate (TPA) could partially block cellular crosstalk.	Tetradecanoylphorbol Acetate	139-142	gap junction protein alpha 1	Homo sapiens	17-27
20626007-1	2011	In this study, phorbol-12-myristate-13-acetate (PMA) at low concentrations (&lt;10 nM; L-PMA) induces the differentiation of CD14(+) monocytes into monocyte-derived macrophages (MDMs) while PMA at high concentrations (&gt;100 nM; H-PMA) causes the apoptosis of these cells.	Tetradecanoylphorbol Acetate	15-46	CD14 molecule	Homo sapiens	125-129
21441980-6	2011	We found that treatment of human neuroblastoma-derived Kelly cells with phorbol 12-myristate 13-acetate (PMA) resulted in a fast, strong and long-lasting suppression of hASH1 synthesis.	Tetradecanoylphorbol Acetate	72-103	achaete-scute family bHLH transcription factor 1	Homo sapiens	169-174
21441980-6	2011	We found that treatment of human neuroblastoma-derived Kelly cells with phorbol 12-myristate 13-acetate (PMA) resulted in a fast, strong and long-lasting suppression of hASH1 synthesis.	Tetradecanoylphorbol Acetate	105-108	achaete-scute family bHLH transcription factor 1	Homo sapiens	169-174
20626007-1	2011	In this study, phorbol-12-myristate-13-acetate (PMA) at low concentrations (&lt;10 nM; L-PMA) induces the differentiation of CD14(+) monocytes into monocyte-derived macrophages (MDMs) while PMA at high concentrations (&gt;100 nM; H-PMA) causes the apoptosis of these cells.	Tetradecanoylphorbol Acetate	48-51	CD14 molecule	Homo sapiens	125-129
20626007-1	2011	In this study, phorbol-12-myristate-13-acetate (PMA) at low concentrations (&lt;10 nM; L-PMA) induces the differentiation of CD14(+) monocytes into monocyte-derived macrophages (MDMs) while PMA at high concentrations (&gt;100 nM; H-PMA) causes the apoptosis of these cells.	Tetradecanoylphorbol Acetate	89-92	CD14 molecule	Homo sapiens	125-129
21216234-5	2011	In megakaryoblastic cell line Dami, the membrane protein expression of LAIR-1 is up-regulated significantly when cells are treated with phorbol ester phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	150-181	leukocyte associated immunoglobulin like receptor 1	Homo sapiens	71-77
20626007-1	2011	In this study, phorbol-12-myristate-13-acetate (PMA) at low concentrations (&lt;10 nM; L-PMA) induces the differentiation of CD14(+) monocytes into monocyte-derived macrophages (MDMs) while PMA at high concentrations (&gt;100 nM; H-PMA) causes the apoptosis of these cells.	Tetradecanoylphorbol Acetate	89-92	CD14 molecule	Homo sapiens	125-129
21216234-5	2011	In megakaryoblastic cell line Dami, the membrane protein expression of LAIR-1 is up-regulated significantly when cells are treated with phorbol ester phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	183-186	leukocyte associated immunoglobulin like receptor 1	Homo sapiens	71-77
21542454-9	2011	Tumors obtained in DMBA/TPA group were associated with enhanced expression of NF-kappaB and AP-1 when compared to the control counterparts.	Tetradecanoylphorbol Acetate	24-27	jun proto-oncogene	Mus musculus	92-96
20953574-5	2011	Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1.	Tetradecanoylphorbol Acetate	95-126	RAB7B, member RAS oncogene family	Homo sapiens	22-27
20953574-5	2011	Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1.	Tetradecanoylphorbol Acetate	128-131	RAB7B, member RAS oncogene family	Homo sapiens	22-27
20953574-9	2011	In Rab7b-silenced cells, PMA-induced activation of NF-kappaB, IL-6 production, and megakaryocytic differentiation are impaired.	Tetradecanoylphorbol Acetate	25-28	RAB7B, member RAS oncogene family	Homo sapiens	3-8
21039753-12	2011	The results of the present study suggest that artemisinin inhibits EMMPRIN and MMP-9 expression and activity by suppressing the PKCdelta/ERK/p38 cascade in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	156-159	protein kinase C delta	Homo sapiens	128-136
20708645-5	2010	Phorbol ester (PMA)- and insulin-induced degradation of PKCdelta were abrogated by proteasome inhibition.	Tetradecanoylphorbol Acetate	15-18	protein kinase C delta	Homo sapiens	56-64
21649590-9	2011	In the active group median percent decrease of Lp(a) level was 23% (from 84+/-40 to 67+/-25 mg/dl after 6 weeks and up to 65+/-37 mg/dl after 6 months of treatment, p&lt;0.01); LDL-C, TG, tPA/PAI-1, and Lp-PL-2 mass levels decreased by 25, 20, 25, and 32%, respectively; HDL-C increased by 16% (p&lt;0.05 vs baseline, respectively).	Tetradecanoylphorbol Acetate	188-191	lipoprotein(a)	Homo sapiens	47-52
20976134-7	2010	Moreover, uncoupling protein 2 (UCP2), a potential suppressor of ROS in mitochondria, is important for TPA-induced cell transformation in JB6 cells.	Tetradecanoylphorbol Acetate	103-106	uncoupling protein 2	Homo sapiens	10-30
20976134-7	2010	Moreover, uncoupling protein 2 (UCP2), a potential suppressor of ROS in mitochondria, is important for TPA-induced cell transformation in JB6 cells.	Tetradecanoylphorbol Acetate	103-106	uncoupling protein 2	Homo sapiens	32-36
20976134-8	2010	UCP2 knock down cells showed enhanced p53 mitochondrial translocation, and were less prone to form colonies in soft agar after TPA treatment.	Tetradecanoylphorbol Acetate	127-130	uncoupling protein 2	Homo sapiens	0-4
22257230-2	2011	Together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI-1, PAI-2, PAI-3 and protease nexin), it forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing to the invasive growth and angiogenesis of malignant tumours.	Tetradecanoylphorbol Acetate	53-56	serpin family A member 5	Homo sapiens	98-103
20213532-3	2010	If activation of p44/42 is required for TBT-induced decreases of lytic function, then activation of p44/42 to similar extents by pharmacological agents such as phorbol 12-myristate 13-acetate (PMA) should mimic to some extent changes induced in NK cells with TBT exposures.	Tetradecanoylphorbol Acetate	160-191	interferon induced protein 44	Homo sapiens	17-20
21028875-2	2010	TPA inhibited GJIC in a dose-dependent and reversible manner and was associated with connexin 43 phosphorylation.	Tetradecanoylphorbol Acetate	0-3	gap junction protein alpha 1	Homo sapiens	85-96
21028875-3	2010	Pretreatment of 20 muM c9,t11-CLA for 24 h prior to 60 nM TPA for 1 h prevented the inhibition of GJIC by reducing the phosphorylation of connexin 43 via suppressing extracellular signal-regulated kinases (ERK1/2) activation.	Tetradecanoylphorbol Acetate	58-61	gap junction protein alpha 1	Homo sapiens	138-149
20213532-3	2010	If activation of p44/42 is required for TBT-induced decreases of lytic function, then activation of p44/42 to similar extents by pharmacological agents such as phorbol 12-myristate 13-acetate (PMA) should mimic to some extent changes induced in NK cells with TBT exposures.	Tetradecanoylphorbol Acetate	160-191	interferon induced protein 44	Homo sapiens	100-103
20213532-3	2010	If activation of p44/42 is required for TBT-induced decreases of lytic function, then activation of p44/42 to similar extents by pharmacological agents such as phorbol 12-myristate 13-acetate (PMA) should mimic to some extent changes induced in NK cells with TBT exposures.	Tetradecanoylphorbol Acetate	193-196	interferon induced protein 44	Homo sapiens	100-103
20213532-6	2010	Western blot analysis showed that a 1-h exposure to 5 nM PMA caused a sixfold increase in phospho-p44/42 levels.	Tetradecanoylphorbol Acetate	57-60	interferon induced protein 44	Homo sapiens	98-101
20688835-2	2010	Our previous studies revealed that PLCepsilon gene-knockout (PLCepsilon(-/-)) mice exhibit marked resistance to tumor formation in two-stage skin chemical carcinogenesis using 7,12-dimethylbenz(a)anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate as a promoter.	Tetradecanoylphorbol Acetate	227-263	phospholipase C, epsilon 1	Mus musculus	35-45
20973493-1	2010	Bridging the triindole core and triarylboryl acceptor by an ethenylene linker at the 3,8,13- or 2,7,12-position, the resultant 3-BET and 2-BET show two-photon absorption (TPA) cross sections of delta = 2100 and 2500 GM (at 810 nm by femtosecond pulses in THF), respectively.	Tetradecanoylphorbol Acetate	171-174	delta/notch like EGF repeat containing	Homo sapiens	129-132
20973493-1	2010	Bridging the triindole core and triarylboryl acceptor by an ethenylene linker at the 3,8,13- or 2,7,12-position, the resultant 3-BET and 2-BET show two-photon absorption (TPA) cross sections of delta = 2100 and 2500 GM (at 810 nm by femtosecond pulses in THF), respectively.	Tetradecanoylphorbol Acetate	171-174	delta/notch like EGF repeat containing	Homo sapiens	139-142
20688835-2	2010	Our previous studies revealed that PLCepsilon gene-knockout (PLCepsilon(-/-)) mice exhibit marked resistance to tumor formation in two-stage skin chemical carcinogenesis using 7,12-dimethylbenz(a)anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate as a promoter.	Tetradecanoylphorbol Acetate	227-263	phospholipase C, epsilon 1	Mus musculus	61-71
20826794-5	2010	However, pretreatment with the protein kinase C activator 4beta-phorbol 12-myristate 13-acetate (PMA) resulted in a significantly sensitized propofol-induced activation of TRPV1 in DRG neurons as well as in HEK293t cells.	Tetradecanoylphorbol Acetate	58-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	172-177
20688835-3	2010	In this model, PLCepsilon functions in tumor promotion through augmentation of 12-O-tetradecanoylphorbol-13-acetate-induced inflammation.	Tetradecanoylphorbol Acetate	79-115	phospholipase C, epsilon 1	Mus musculus	15-25
20826794-5	2010	However, pretreatment with the protein kinase C activator 4beta-phorbol 12-myristate 13-acetate (PMA) resulted in a significantly sensitized propofol-induced activation of TRPV1 in DRG neurons as well as in HEK293t cells.	Tetradecanoylphorbol Acetate	97-100	transient receptor potential cation channel subfamily V member 1	Homo sapiens	172-177
20688835-7	2010	However, UVB-induced skin inflammation was greatly suppressed in PLCepsilon(-/-) mice, as observed with 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, implying that PLCepsilon"s role in the suppression of UVB-induced tumorigenesis is not mediated by inflammation.	Tetradecanoylphorbol Acetate	104-140	phospholipase C, epsilon 1	Mus musculus	65-75
20458747-4	2010	Activation of NF-kappaB protein p65 nuclear translocation and IkappaBalpha protein phosphorylation with increased NF-kappaB-directed luciferase activity by TPA were observed, and these were blocked by the PD98059 and IkB inhibitor BAY117082 accompanied by reducing migration and MMP-9 activity induced by TPA in GBM8401 cells.	Tetradecanoylphorbol Acetate	156-159	RELA proto-oncogene, NF-kB subunit	Homo sapiens	32-35
20688835-7	2010	However, UVB-induced skin inflammation was greatly suppressed in PLCepsilon(-/-) mice, as observed with 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, implying that PLCepsilon"s role in the suppression of UVB-induced tumorigenesis is not mediated by inflammation.	Tetradecanoylphorbol Acetate	104-140	phospholipase C, epsilon 1	Mus musculus	177-187
20458747-4	2010	Activation of NF-kappaB protein p65 nuclear translocation and IkappaBalpha protein phosphorylation with increased NF-kappaB-directed luciferase activity by TPA were observed, and these were blocked by the PD98059 and IkB inhibitor BAY117082 accompanied by reducing migration and MMP-9 activity induced by TPA in GBM8401 cells.	Tetradecanoylphorbol Acetate	305-308	RELA proto-oncogene, NF-kB subunit	Homo sapiens	32-35
20731354-4	2010	Topical application of TPA to ears of CD-1 mice induced inflammation accompanied with substantial increase in TNF-alpha, IL-1beta, IL-6, LTB4, and PGE2 levels and an elevation in intercellular adhesion molecule-1 (ICAM-1) gene expressions in ear skin tissues.	Tetradecanoylphorbol Acetate	23-26	intercellular adhesion molecule 1	Mus musculus	179-212
20731354-4	2010	Topical application of TPA to ears of CD-1 mice induced inflammation accompanied with substantial increase in TNF-alpha, IL-1beta, IL-6, LTB4, and PGE2 levels and an elevation in intercellular adhesion molecule-1 (ICAM-1) gene expressions in ear skin tissues.	Tetradecanoylphorbol Acetate	23-26	intercellular adhesion molecule 1	Mus musculus	214-220
20883105-3	2010	To understand the role that p44/42 activation plays in TBT-induced loss of NK cell function, this study investigated how selective activation of p44/42 by phorbol 12-myristate 13-acetate (PMA) affects NK cells.	Tetradecanoylphorbol Acetate	155-186	interferon induced protein 44	Homo sapiens	145-148
20471435-4	2010	However, the mechanisms of TPA action on PDCD4 expression remain to be elucidated.	Tetradecanoylphorbol Acetate	27-30	programmed cell death 4	Homo sapiens	41-46
20883105-3	2010	To understand the role that p44/42 activation plays in TBT-induced loss of NK cell function, this study investigated how selective activation of p44/42 by phorbol 12-myristate 13-acetate (PMA) affects NK cells.	Tetradecanoylphorbol Acetate	188-191	interferon induced protein 44	Homo sapiens	145-148
20471435-7	2010	The treatment of the human hepatoma cell line, Huh7 with TPA suppressed PDCD4 protein expression and TGF-beta1 failed to increase the PDCD4 protein expression.	Tetradecanoylphorbol Acetate	57-60	programmed cell death 4	Homo sapiens	72-77
20709134-3	2010	Topical application of the vector markedly inhibited TPA-induced expression levels of cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines.	Tetradecanoylphorbol Acetate	53-56	prostaglandin-endoperoxide synthase 2	Mus musculus	86-102
20709134-3	2010	Topical application of the vector markedly inhibited TPA-induced expression levels of cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines.	Tetradecanoylphorbol Acetate	53-56	prostaglandin-endoperoxide synthase 2	Mus musculus	104-109
20471435-11	2010	The down-regulation of PDCD4 by TPA was restored by treatment with the proteasome inhibitor MG132.	Tetradecanoylphorbol Acetate	32-35	programmed cell death 4	Homo sapiens	23-28
20652762-0	2010	Alpha-mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells.	Tetradecanoylphorbol Acetate	27-58	matrix metallopeptidase 2	Homo sapiens	67-72
20660715-6	2010	Inhibitors of EGFR/MEK signaling suppressed TPA/capsaicin-induced COX-2 expression in TRPV1/KO cells, indicating that activation of EGFR and its downstream signaling is involved in COX-2 elevation.	Tetradecanoylphorbol Acetate	44-47	prostaglandin-endoperoxide synthase 2	Mus musculus	66-71
20660715-6	2010	Inhibitors of EGFR/MEK signaling suppressed TPA/capsaicin-induced COX-2 expression in TRPV1/KO cells, indicating that activation of EGFR and its downstream signaling is involved in COX-2 elevation.	Tetradecanoylphorbol Acetate	44-47	prostaglandin-endoperoxide synthase 2	Mus musculus	181-186
20660715-7	2010	Capsaicin induced a further induction of TPA-increased COX-2 expression in EGFR/WT cells, but not in EGFR/KO cells.	Tetradecanoylphorbol Acetate	41-44	prostaglandin-endoperoxide synthase 2	Mus musculus	55-60
20336681-6	2010	Moreover, 6-shogaol markedly suppressed TPA-induced activation of extracellular signal-regulate kinase1/2, p38 mitogen-activated protein kinase, JNK1/2, and phosphatidylinositol 3-kinase/Akt, which are upstream of nuclear factor-kappaB and AP-1.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 14	Mus musculus	107-110
20336681-3	2010	We demonstrate that topical application of 6-shogaol more effectively inhibited 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated transcription of iNOS and COX-2 mRNA expression in mouse skin than curcumin and 6-gingerol.	Tetradecanoylphorbol Acetate	80-116	prostaglandin-endoperoxide synthase 2	Mus musculus	160-165
20336681-3	2010	We demonstrate that topical application of 6-shogaol more effectively inhibited 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated transcription of iNOS and COX-2 mRNA expression in mouse skin than curcumin and 6-gingerol.	Tetradecanoylphorbol Acetate	118-121	prostaglandin-endoperoxide synthase 2	Mus musculus	160-165
20566751-7	2010	Furthermore, a PKC-delta inhibitor, rottlerin, prevented up-regulation of claudin-7, occludin, ZO-1, and ZO-2 by TPA.	Tetradecanoylphorbol Acetate	113-116	claudin 7	Homo sapiens	74-83
20516369-7	2010	Moreover, bryostatin 1 prevented PMA-induced PKCdelta peripheral translocation.	Tetradecanoylphorbol Acetate	33-36	protein kinase C delta	Homo sapiens	45-53
20566751-7	2010	Furthermore, a PKC-delta inhibitor, rottlerin, prevented up-regulation of claudin-7, occludin, ZO-1, and ZO-2 by TPA.	Tetradecanoylphorbol Acetate	113-116	occludin	Homo sapiens	85-93
20566751-7	2010	Furthermore, a PKC-delta inhibitor, rottlerin, prevented up-regulation of claudin-7, occludin, ZO-1, and ZO-2 by TPA.	Tetradecanoylphorbol Acetate	113-116	tight junction protein 2	Homo sapiens	105-109
20566751-9	2010	Treatment with small interfering RNAs of ELF3 prevented up-regulation of claudin-7 by TPA.	Tetradecanoylphorbol Acetate	86-89	claudin 7	Homo sapiens	73-82
20508956-8	2010	Most of the syncytia were viable and expressed CD25 and IL-2 in response to activation by phorbol myristate acetate (PMA) and ionomicyn.	Tetradecanoylphorbol Acetate	90-115	interleukin 2 receptor subunit alpha	Homo sapiens	47-51
20669099-12	2010	PMA-induced cell death occurred if the phospho-NF-kappaB/p65 was prohibited from entering the nucleus in PKC delta positive cells.	Tetradecanoylphorbol Acetate	0-3	RELA proto-oncogene, NF-kB subunit	Homo sapiens	57-60
20508956-8	2010	Most of the syncytia were viable and expressed CD25 and IL-2 in response to activation by phorbol myristate acetate (PMA) and ionomicyn.	Tetradecanoylphorbol Acetate	117-120	interleukin 2 receptor subunit alpha	Homo sapiens	47-51
20669099-12	2010	PMA-induced cell death occurred if the phospho-NF-kappaB/p65 was prohibited from entering the nucleus in PKC delta positive cells.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	105-114
20152819-8	2010	Furthermore, DHA strongly repressed the PMA-induced phosphorylation of Raf/ERK and JNK, which are dependent on the PKCalpha pathway.	Tetradecanoylphorbol Acetate	40-43	zinc fingers and homeoboxes 2	Homo sapiens	71-74
20298789-12	2010	PMA stimulation elicited a significant upregulation of IRF4 expression.	Tetradecanoylphorbol Acetate	0-3	interferon regulatory factor 4	Homo sapiens	55-59
20566912-6	2010	In addition, we evaluated the effect of 4 physiologically relevant agents, including retinoic acid, interleukin 1beta, phorbol 12-myristate 13-acetate (PMA), and dexamethasone, on the expression of MUC4 and MUC16 in HNPE cells at the gene and protein levels.	Tetradecanoylphorbol Acetate	119-150	mucin 4, cell surface associated	Homo sapiens	198-202
20237492-1	2010	Recently, we identified an AP-1-dependent target gene in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated mouse back skin, which encodes a retroviral-like aspartic proteinase (Taps/Asprv1).	Tetradecanoylphorbol Acetate	57-93	aspartic peptidase, retroviral-like 1	Mus musculus	183-189
20237492-1	2010	Recently, we identified an AP-1-dependent target gene in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated mouse back skin, which encodes a retroviral-like aspartic proteinase (Taps/Asprv1).	Tetradecanoylphorbol Acetate	95-98	aspartic peptidase, retroviral-like 1	Mus musculus	183-189
20566912-6	2010	In addition, we evaluated the effect of 4 physiologically relevant agents, including retinoic acid, interleukin 1beta, phorbol 12-myristate 13-acetate (PMA), and dexamethasone, on the expression of MUC4 and MUC16 in HNPE cells at the gene and protein levels.	Tetradecanoylphorbol Acetate	152-155	mucin 4, cell surface associated	Homo sapiens	198-202
20237492-6	2010	A hypergranulosum-like phenotype with increased numbers of Filaggrin-positive keratinocytes was also observed in UBC-Taps mice after administration of TPA.	Tetradecanoylphorbol Acetate	151-154	filaggrin	Mus musculus	59-68
20172950-3	2010	Surprisingly, TGFbeta1+/- mice had fewer number and incidence of benign papillomas, reduced epidermal and tumor cell proliferation and reduced epidermal TGFbeta1 and nuclear p-Smad2 localization in response to the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) compared with TGFbeta1+/+ mice.	Tetradecanoylphorbol Acetate	229-265	transforming growth factor, beta 1	Mus musculus	14-22
20478695-12	2010	TPA, a potent activator of protein kinase C, increased Blimp1 mRNA but not CYP1A1.	Tetradecanoylphorbol Acetate	0-3	PR domain containing 1, with ZNF domain	Mus musculus	55-61
20033927-5	2010	Surprisingly, PKC activation using phorbol 12-myristate 13-acetate (PMA) also resulted in inhibition of osteogenesis, although we observed that inhibition was more pronounced at low than at high concentrations of PMA.	Tetradecanoylphorbol Acetate	35-66	protein kinase C delta	Homo sapiens	14-17
20033927-5	2010	Surprisingly, PKC activation using phorbol 12-myristate 13-acetate (PMA) also resulted in inhibition of osteogenesis, although we observed that inhibition was more pronounced at low than at high concentrations of PMA.	Tetradecanoylphorbol Acetate	68-71	protein kinase C delta	Homo sapiens	14-17
20033927-5	2010	Surprisingly, PKC activation using phorbol 12-myristate 13-acetate (PMA) also resulted in inhibition of osteogenesis, although we observed that inhibition was more pronounced at low than at high concentrations of PMA.	Tetradecanoylphorbol Acetate	213-216	protein kinase C delta	Homo sapiens	14-17
20564344-5	2010	DIM inhibited the TPA-induced increases in the expression of cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), chemokine (C-X-C motif) ligand (CXCL) 5, and interleukin (IL)-6 in mouse skin.	Tetradecanoylphorbol Acetate	18-21	cytochrome c oxidase II, mitochondrial	Mus musculus	61-83
20335173-4	2010	Epidermal growth factor or the phorbol ester phorbol 12-myristate 13-acetate caused rapid phosphorylation of beta2-chimaerin on Ser(169) located in the SH2-C1 domain linker region via protein kinase Cdelta, which retained beta2-chimaerin in the cytosol and prevented its C1 domain-mediated translocation to membranes.	Tetradecanoylphorbol Acetate	45-76	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	109-114
20564344-5	2010	DIM inhibited the TPA-induced increases in the expression of cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), chemokine (C-X-C motif) ligand (CXCL) 5, and interleukin (IL)-6 in mouse skin.	Tetradecanoylphorbol Acetate	18-21	chemokine (C-X-C motif) ligand 5	Mus musculus	136-164
20564344-7	2010	Furthermore, DIM reduced TPA-induced increases in the activity of extracellular signal regulated protein kinase (ERK)-1/2 and IkappaB kinase (IKK).	Tetradecanoylphorbol Acetate	25-28	mitogen-activated protein kinase 3	Mus musculus	66-121
20669099-3	2010	MATERIAL AND METHODS: The activation of NF-kappaB by PKC alpha and PKC delta was assessed by Western blotting after the stimulation with Phorbol 12- Myristate 13-Acetate (PMA).	Tetradecanoylphorbol Acetate	137-169	protein kinase C delta	Homo sapiens	67-76
20669099-3	2010	MATERIAL AND METHODS: The activation of NF-kappaB by PKC alpha and PKC delta was assessed by Western blotting after the stimulation with Phorbol 12- Myristate 13-Acetate (PMA).	Tetradecanoylphorbol Acetate	171-174	protein kinase C delta	Homo sapiens	67-76
20669099-5	2010	RESULTS: PMA induced the phosphorylation of NF-kappaB/p65 by PKC alpha.	Tetradecanoylphorbol Acetate	9-12	RELA proto-oncogene, NF-kB subunit	Homo sapiens	54-57
20152819-4	2010	DHA reduced PMA-induced activation of MMP-9 and MMP-2 and further inhibited cell invasion and migration.	Tetradecanoylphorbol Acetate	12-15	matrix metallopeptidase 2	Homo sapiens	48-53
20335173-4	2010	Epidermal growth factor or the phorbol ester phorbol 12-myristate 13-acetate caused rapid phosphorylation of beta2-chimaerin on Ser(169) located in the SH2-C1 domain linker region via protein kinase Cdelta, which retained beta2-chimaerin in the cytosol and prevented its C1 domain-mediated translocation to membranes.	Tetradecanoylphorbol Acetate	45-76	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	222-227
20302858-6	2010	Among these human DNA helicase genes, XPB, RecQL5, and RTEL promoters were activated during TPA-induced HL-60 cell differentiation.	Tetradecanoylphorbol Acetate	92-95	RecQ like helicase 5	Homo sapiens	43-49
20302858-6	2010	Among these human DNA helicase genes, XPB, RecQL5, and RTEL promoters were activated during TPA-induced HL-60 cell differentiation.	Tetradecanoylphorbol Acetate	92-95	regulator of telomere elongation helicase 1	Homo sapiens	55-59
20383193-3	2010	Using mice with a keratinocyte-restricted deletion of the Rac1 gene, we found that Rac1 is essential for DMBA/TPA-induced skin tumor formation.	Tetradecanoylphorbol Acetate	110-113	Rac family small GTPase 1	Mus musculus	58-62
20302858-10	2010	TPA-induced response of 44-bp in the RTEL promoter was attenuated by co-transfection of the PU.1 expression vector.	Tetradecanoylphorbol Acetate	0-3	regulator of telomere elongation helicase 1	Homo sapiens	37-41
20383193-3	2010	Using mice with a keratinocyte-restricted deletion of the Rac1 gene, we found that Rac1 is essential for DMBA/TPA-induced skin tumor formation.	Tetradecanoylphorbol Acetate	110-113	Rac family small GTPase 1	Mus musculus	83-87
20459780-7	2010	PMA/ionomycin stimulation induced a stronger up-regulation of T cell activation than of B cell activation with dominance toward a Th1 response, including IL2, CD69 and TNFRSF9 (tumor necrosis factor receptor superfamily, member 9) genes.	Tetradecanoylphorbol Acetate	0-3	CD69 molecule	Sus scrofa	159-163
20188714-8	2010	Furthermore, glycitein suppresses PMA-induced phosphorylation of three types of MAP kinases, which are upstream signaling molecules in MMP gene expressions and NF-kappaB and AP-1 activities in glioma cells.	Tetradecanoylphorbol Acetate	34-37	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	174-178
20232358-1	2010	Dietary energy restriction (DER, 40% calorie reduction from fat and carbohydrate) inhibited mouse skin carcinogenesis and decreased 12-O-tetradecanoyl-13-phorbol acetate (TPA)-induced activator protein-1 (AP-1):DNA binding previously.	Tetradecanoylphorbol Acetate	171-174	jun proto-oncogene	Mus musculus	205-209
20232358-3	2010	TPA significantly increased c-jun, jun B, c-fos, fra-1, and fra-2 and decreased jun D within 3-6 h after treatment.	Tetradecanoylphorbol Acetate	0-3	jun proto-oncogene	Mus musculus	28-33
20232358-4	2010	AP-1:DNA binding reached a maximum 2.5-fold induction over controls 4 h after TPA treatment and antibodies to jun B, jun D, and fra-2 in the EMSA binding reaction resulted in supershifts in both acetone- and TPA-treated mice 1-6 h after treatment.	Tetradecanoylphorbol Acetate	78-81	jun proto-oncogene	Mus musculus	0-4
20232358-4	2010	AP-1:DNA binding reached a maximum 2.5-fold induction over controls 4 h after TPA treatment and antibodies to jun B, jun D, and fra-2 in the EMSA binding reaction resulted in supershifts in both acetone- and TPA-treated mice 1-6 h after treatment.	Tetradecanoylphorbol Acetate	208-211	jun proto-oncogene	Mus musculus	0-4
20232358-8	2010	While sham animals treated with either acetone or TPA contained jun B, jun D, and fra-2 proteins in the AP-1:DNA complex by supershift analysis, fra-2 was no longer seen in adx DER animals.	Tetradecanoylphorbol Acetate	50-53	jun proto-oncogene	Mus musculus	104-108
20056911-5	2010	Phorbol-12-myristate-13 acetate (PMA) upregulates MMP-14 mRNA via protein kinase C-extracellular signal-regulated kinase pathways, and enhanced soluble Tie-2 production in an MMP-14-dependent manner, resulting in a reduction of cellular fTie-2.	Tetradecanoylphorbol Acetate	0-31	matrix metallopeptidase 14	Homo sapiens	175-181
20299489-9	2010	Taken together, the results show that PMA activates the MEK-ERK pathway and strongly induces miRNA-34a expression, which in turn inhibits cell proliferation by repressing the expression of MEK1.	Tetradecanoylphorbol Acetate	38-41	microRNA 34a	Homo sapiens	93-102
20056911-5	2010	Phorbol-12-myristate-13 acetate (PMA) upregulates MMP-14 mRNA via protein kinase C-extracellular signal-regulated kinase pathways, and enhanced soluble Tie-2 production in an MMP-14-dependent manner, resulting in a reduction of cellular fTie-2.	Tetradecanoylphorbol Acetate	33-36	matrix metallopeptidase 14	Homo sapiens	50-56
20056911-5	2010	Phorbol-12-myristate-13 acetate (PMA) upregulates MMP-14 mRNA via protein kinase C-extracellular signal-regulated kinase pathways, and enhanced soluble Tie-2 production in an MMP-14-dependent manner, resulting in a reduction of cellular fTie-2.	Tetradecanoylphorbol Acetate	33-36	TEK receptor tyrosine kinase	Homo sapiens	152-157
20381601-3	2010	Expression of IL-18 was investigated after exposure of murine keratinocytes PAM212 to pro-inflammatory stimuli, allergen TNCB (Trinitrichlorobenzen), LPS (lipopolysaccharide) or PMA (phorbol myristate acetate).	Tetradecanoylphorbol Acetate	178-181	interleukin 18	Mus musculus	14-19
20381601-3	2010	Expression of IL-18 was investigated after exposure of murine keratinocytes PAM212 to pro-inflammatory stimuli, allergen TNCB (Trinitrichlorobenzen), LPS (lipopolysaccharide) or PMA (phorbol myristate acetate).	Tetradecanoylphorbol Acetate	183-208	interleukin 18	Mus musculus	14-19
20056911-5	2010	Phorbol-12-myristate-13 acetate (PMA) upregulates MMP-14 mRNA via protein kinase C-extracellular signal-regulated kinase pathways, and enhanced soluble Tie-2 production in an MMP-14-dependent manner, resulting in a reduction of cellular fTie-2.	Tetradecanoylphorbol Acetate	33-36	matrix metallopeptidase 14	Homo sapiens	175-181
20218615-2	2010	Herein, we report the investigation of the inhibitory effects of magnolol on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	77-113	prostaglandin-endoperoxide synthase 2	Mus musculus	185-201
20163138-6	2010	In contrast, chimera Nox4/2, consisting of the Nox4 TM and Nox2 DH domains, exhibited PMA-dependent activation that required coexpression of regulatory subunits.	Tetradecanoylphorbol Acetate	86-89	NADPH oxidase 4	Homo sapiens	47-51
20218615-2	2010	Herein, we report the investigation of the inhibitory effects of magnolol on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	77-113	prostaglandin-endoperoxide synthase 2	Mus musculus	203-208
20218615-2	2010	Herein, we report the investigation of the inhibitory effects of magnolol on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	115-118	prostaglandin-endoperoxide synthase 2	Mus musculus	185-201
20218615-2	2010	Herein, we report the investigation of the inhibitory effects of magnolol on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	115-118	prostaglandin-endoperoxide synthase 2	Mus musculus	203-208
20218615-3	2010	We found that the topical application of magnolol effectively inhibited the transcriptional activation of iNOS and COX-2 mRNA and proteins in mouse skin stimulated by TPA.	Tetradecanoylphorbol Acetate	167-170	prostaglandin-endoperoxide synthase 2	Mus musculus	115-120
20179211-4	2010	DATS significantly attenuated the DNA binding of activator protein-1 (AP-1), one of the transcription factors that regulate COX-2 expression, in TPA-stimulated mouse skin.	Tetradecanoylphorbol Acetate	145-148	jun proto-oncogene	Mus musculus	49-68
20179211-4	2010	DATS significantly attenuated the DNA binding of activator protein-1 (AP-1), one of the transcription factors that regulate COX-2 expression, in TPA-stimulated mouse skin.	Tetradecanoylphorbol Acetate	145-148	jun proto-oncogene	Mus musculus	70-74
20179211-5	2010	DATS also diminished TPA-induced expression of c-Jun and c-Fos, the principal components of AP-1, and blunted the activation of c-Jun NH(2)-terminal kinase (JNK) and Akt.	Tetradecanoylphorbol Acetate	21-24	jun proto-oncogene	Mus musculus	47-52
20179211-5	2010	DATS also diminished TPA-induced expression of c-Jun and c-Fos, the principal components of AP-1, and blunted the activation of c-Jun NH(2)-terminal kinase (JNK) and Akt.	Tetradecanoylphorbol Acetate	21-24	jun proto-oncogene	Mus musculus	92-96
20179211-7	2010	The JNK or Akt kinase assay, taking c-Jun fusion protein as a substrate, revealed that TPA induced JNK- or Akt-mediated c-Jun phosphorylation in mouse skin, which was significantly attenuated by DATS or respective pharmacologic inhibitors.	Tetradecanoylphorbol Acetate	87-90	jun proto-oncogene	Mus musculus	36-41
20414189-3	2010	We obtained precise quantitative and qualitative measures for the production of interferon gamma (INF-) and interleukin (IL) -2 in both CD4+ and CD8+ T cells from the rhesus macaque PBMC stimulated with PMA plus ionomycin (PMA+I).	Tetradecanoylphorbol Acetate	203-206	interleukin 2	Macaca mulatta	80-127
20179211-7	2010	The JNK or Akt kinase assay, taking c-Jun fusion protein as a substrate, revealed that TPA induced JNK- or Akt-mediated c-Jun phosphorylation in mouse skin, which was significantly attenuated by DATS or respective pharmacologic inhibitors.	Tetradecanoylphorbol Acetate	87-90	jun proto-oncogene	Mus musculus	120-125
20414189-3	2010	We obtained precise quantitative and qualitative measures for the production of interferon gamma (INF-) and interleukin (IL) -2 in both CD4+ and CD8+ T cells from the rhesus macaque PBMC stimulated with PMA plus ionomycin (PMA+I).	Tetradecanoylphorbol Acetate	223-226	interleukin 2	Macaca mulatta	80-127
20179211-9	2010	Taken together, the inhibitory effects of DATS on TPA-induced AP-1 activation and COX-2 expression through modulation of JNK or Akt signaling may partly account for its antitumor-promoting effect on mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	50-53	jun proto-oncogene	Mus musculus	62-66
20492173-0	2010	alpha-Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells.	Tetradecanoylphorbol Acetate	54-57	matrix metallopeptidase 2	Homo sapiens	67-72
20082322-7	2010	While the proliferative response to phorbol-12-myristate-13-acetate (TPA) did not differ among the genotypes, sdc-1 null mice had an enhanced inflammatory response and retained higher levels of total TGFbeta1 within their skin after TPA treatment.	Tetradecanoylphorbol Acetate	233-236	syndecan 1	Mus musculus	110-115
20492173-1	2010	This study first investigates the anti-metastatic effect of alpha-mangostin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in human breast adenocarcinoma cells, MCF-7.	Tetradecanoylphorbol Acetate	79-115	matrix metallopeptidase 2	Homo sapiens	130-156
20492173-1	2010	This study first investigates the anti-metastatic effect of alpha-mangostin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in human breast adenocarcinoma cells, MCF-7.	Tetradecanoylphorbol Acetate	79-115	matrix metallopeptidase 2	Homo sapiens	158-163
19406475-3	2010	On the other hand, in H9 cells TPA activates the LTR by two consecutive mechanisms; the first depends on PKCeta activity and is exerted through the 21 bp repeats of the LTR, whereas the second is analogous to that observed in Jurkat cells, except that it is antagonized by PKCdelta.	Tetradecanoylphorbol Acetate	31-34	protein kinase C delta	Homo sapiens	273-281
20152816-6	2010	The use of various inhibitors specific for PKC isoforms demonstrated that the novel PKC-theta/delta isoforms mediate the PMA effects.	Tetradecanoylphorbol Acetate	121-124	protein kinase C delta	Homo sapiens	43-46
19995395-4	2010	When placed in culture, NOTCH2 activity was spontaneously decreased in 25 out of 31 CLL cases (81%) within 24 h. DNA-bound N2(IC) complexes could be maintained by the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) or by gamma-interferon (IFN-gamma), two CLL characteristic inducers of CD23 expression.	Tetradecanoylphorbol Acetate	200-231	protein kinase C delta	Homo sapiens	185-188
19995395-5	2010	Inhibition of PKC-delta by RNA interference or by rottlerin antagonised PMA-induced NOTCH2 activation and also suppressed NOTCH2 activity in CLL cases with constitutively activated NOTCH2 signalling.	Tetradecanoylphorbol Acetate	72-75	protein kinase C delta	Homo sapiens	14-23
20624010-9	2010	Consistent with previous reports phorbol 12-myristate 13-acetate (PMA; 300 nM) induced phosphorylation of VASP at Ser(157), but not Ser(239), which was blocked by general protein kinase C (PKC) inhibitors, Ro31-8220 and Bisindolylmaleimide I (BIM-1), and Go6976, an inhibitor of conventional PKC isoforms.	Tetradecanoylphorbol Acetate	33-64	vasodilator stimulated phosphoprotein	Homo sapiens	106-110
20624010-9	2010	Consistent with previous reports phorbol 12-myristate 13-acetate (PMA; 300 nM) induced phosphorylation of VASP at Ser(157), but not Ser(239), which was blocked by general protein kinase C (PKC) inhibitors, Ro31-8220 and Bisindolylmaleimide I (BIM-1), and Go6976, an inhibitor of conventional PKC isoforms.	Tetradecanoylphorbol Acetate	66-69	vasodilator stimulated phosphoprotein	Homo sapiens	106-110
20178722-9	2010	RESULTS: At baseline, respiratory burst of PMA-stimulated monocytes was higher in patients with IgAN as compared to that in healthy subjects (p = 0.002).	Tetradecanoylphorbol Acetate	43-46	IGAN1	Homo sapiens	96-100
19895572-7	2010	PMA-induced translocation of conventional PKC (cPKC) isozymes (alpha, beta and gamma), but decreased the expression of PKC-delta, which plays an important role in CD98-induced homotypic aggregation.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	119-128
20139271-5	2010	Stimulation with PMA/ionomycin caused splenic CD4(+)PD-1(+) T cells to secrete high levels of IFN-gamma, IL-10, low levels of TNF-alpha, faint levels of IL-2, IL-21, and no IL-4, IL-17.	Tetradecanoylphorbol Acetate	17-20	interferon gamma	Sus scrofa	94-103
20139271-5	2010	Stimulation with PMA/ionomycin caused splenic CD4(+)PD-1(+) T cells to secrete high levels of IFN-gamma, IL-10, low levels of TNF-alpha, faint levels of IL-2, IL-21, and no IL-4, IL-17.	Tetradecanoylphorbol Acetate	17-20	tumor necrosis factor	Sus scrofa	126-135
20139271-5	2010	Stimulation with PMA/ionomycin caused splenic CD4(+)PD-1(+) T cells to secrete high levels of IFN-gamma, IL-10, low levels of TNF-alpha, faint levels of IL-2, IL-21, and no IL-4, IL-17.	Tetradecanoylphorbol Acetate	17-20	interleukin 21	Sus scrofa	159-164
19759192-6	2009	Analysis of the skin 6 h after TPA treatment showed that the TPA-induced promotion of skin edema, inflammatory leukocyte infiltration, COX-2 expression and PGE(2) production was significantly lower in the skin of the IL-12-KO mice than their wild-type counterparts.	Tetradecanoylphorbol Acetate	61-64	prostaglandin-endoperoxide synthase 2	Mus musculus	135-140
20044140-4	2010	Macrophage migration induced by phorbol 12-myristate 13-acetate (PMA) is significantly attenuated in IRAK-1(-/-) macrophages as compared to wild type macrophages.	Tetradecanoylphorbol Acetate	32-63	interleukin 1 receptor associated kinase 1	Homo sapiens	101-107
20044140-4	2010	Macrophage migration induced by phorbol 12-myristate 13-acetate (PMA) is significantly attenuated in IRAK-1(-/-) macrophages as compared to wild type macrophages.	Tetradecanoylphorbol Acetate	65-68	interleukin 1 receptor associated kinase 1	Homo sapiens	101-107
19841537-2	2009	The annexin A2 complex (termed "A2") is the cell surface coreceptor for plasminogen and TPA and accelerates the catalytic activation of plasmin, the major fibrinolytic agent in mammals.	Tetradecanoylphorbol Acetate	88-91	G protein-coupled receptor 162	Mus musculus	31-35
19768635-0	2010	Plumbagin inhibits TPA-induced MMP-2 and u-PA expressions by reducing binding activities of NF-kappaB and AP-1 via ERK signaling pathway in A549 human lung cancer cells.	Tetradecanoylphorbol Acetate	19-22	matrix metallopeptidase 2	Homo sapiens	31-36
19768635-6	2010	Further, the treatment of specific inhibitor for ERK (U0126) to A549 cells could inhibit TPA-induced MMP-2 and u-PA expressions along with an inhibition on cell invasion and migration.	Tetradecanoylphorbol Acetate	89-92	matrix metallopeptidase 2	Homo sapiens	101-106
19907102-4	2009	PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p&lt;0.05) in THP-1 cells.	Tetradecanoylphorbol Acetate	0-3	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	39-44
19907102-4	2009	PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p&lt;0.05) in THP-1 cells.	Tetradecanoylphorbol Acetate	146-149	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	39-44
19559082-7	2009	These results indicated that BaP induced NCF1/p47(phox) expression and subsequently enhanced superoxide anion production in PMA-treated human macrophages, in an AhR-dependent manner; such an NCF1/NADPH oxidase regulation by polycyclic aromatic hydrocarbons may participate in deleterious effects toward human health triggered by these environmental contaminants, including atherosclerosis and smoking-related diseases.	Tetradecanoylphorbol Acetate	124-127	aryl hydrocarbon receptor	Homo sapiens	161-164
19901084-5	2010	The target constructs were responsive to Pdcd4 degrading conditions (e.g., TPA, p70(S6K1) overactivation), whereas the off-target constructs remained stable.	Tetradecanoylphorbol Acetate	75-78	programmed cell death 4	Homo sapiens	41-46
19901084-8	2010	Among the hits were inhibitors of previously identified critical signaling events for TPA-induced Pdcd4 degradation.	Tetradecanoylphorbol Acetate	86-89	programmed cell death 4	Homo sapiens	98-103
20492175-7	2010	Further, the treatment of specific inhibitor for JNK (SP600125) to A549 cells could inhibit TPA-induced MMP-2 and u-PA expressions along with an inhibition on cell invasion and migration.	Tetradecanoylphorbol Acetate	92-95	matrix metallopeptidase 2	Homo sapiens	104-109
20492175-8	2010	Taken together, these results suggest the antimetastatic effects of acacetin on the TPA-induced A549 cells might be by reducing MMP-2 and u-PA expressions through inhibiting phosphorylation of JNK and reducing NF-kappaB and AP-1 binding activities.	Tetradecanoylphorbol Acetate	84-87	matrix metallopeptidase 2	Homo sapiens	128-133
19420016-0	2009	Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	28-31	protein kinase C delta	Homo sapiens	106-114
19366707-3	2009	Here, we demonstrate that overexpression of NPM (nucleophosmin) significantly suppresses 12-O-tetradecanoylphorbol 13-acetate (TPA)-mediated apoptosis, in part, by blocking the mitochondrial localization of p53.	Tetradecanoylphorbol Acetate	89-125	nucleophosmin 1	Homo sapiens	44-47
19759552-4	2010	The highest-ranked upregulated gene was miR-203, whose expression was significantly upregulated in response to calcium and other inducers of keratinocyte differentiation such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and vitamin D(3).	Tetradecanoylphorbol Acetate	178-214	microRNA 203a	Homo sapiens	40-47
19759552-4	2010	The highest-ranked upregulated gene was miR-203, whose expression was significantly upregulated in response to calcium and other inducers of keratinocyte differentiation such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and vitamin D(3).	Tetradecanoylphorbol Acetate	216-219	microRNA 203a	Homo sapiens	40-47
19366707-3	2009	Here, we demonstrate that overexpression of NPM (nucleophosmin) significantly suppresses 12-O-tetradecanoylphorbol 13-acetate (TPA)-mediated apoptosis, in part, by blocking the mitochondrial localization of p53.	Tetradecanoylphorbol Acetate	89-125	nucleophosmin 1	Homo sapiens	49-62
19148928-3	2009	The phorbol myristate acetate-dependent effects of the material chemistry on cell activation and degradation were evaluated by adding reactive oxygen species scavengers, catalase plus superoxide dismutase to MDM and assaying possible markers of MDM activation: esterase activity, acid phosphatase activity, and high molecular weight group box 1 protein (HMGB1).	Tetradecanoylphorbol Acetate	4-29	high mobility group box 1	Homo sapiens	354-359
19366707-3	2009	Here, we demonstrate that overexpression of NPM (nucleophosmin) significantly suppresses 12-O-tetradecanoylphorbol 13-acetate (TPA)-mediated apoptosis, in part, by blocking the mitochondrial localization of p53.	Tetradecanoylphorbol Acetate	127-130	nucleophosmin 1	Homo sapiens	44-47
19148928-6	2009	Secretion of HMGB1 from MDM on HDI431 was higher than MDI; however only secretion from MDM on HDI was inhibited by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	115-140	high mobility group box 1	Homo sapiens	13-18
19366707-3	2009	Here, we demonstrate that overexpression of NPM (nucleophosmin) significantly suppresses 12-O-tetradecanoylphorbol 13-acetate (TPA)-mediated apoptosis, in part, by blocking the mitochondrial localization of p53.	Tetradecanoylphorbol Acetate	127-130	nucleophosmin 1	Homo sapiens	49-62
19148928-7	2009	In MDM on HDI, catalase plus superoxide dismutase reduced intracellular HMGB1 levels +/- phorbol myristate acetate; whereas, catalase, superoxide dismutase plus phorbol myristate acetate increased intracellular HMGB1 in MDM on MDI, suggesting that esterase and HMGB1 are more specific markers of activation than acid phosphatase.	Tetradecanoylphorbol Acetate	161-186	high mobility group box 1	Homo sapiens	211-216
19148928-7	2009	In MDM on HDI, catalase plus superoxide dismutase reduced intracellular HMGB1 levels +/- phorbol myristate acetate; whereas, catalase, superoxide dismutase plus phorbol myristate acetate increased intracellular HMGB1 in MDM on MDI, suggesting that esterase and HMGB1 are more specific markers of activation than acid phosphatase.	Tetradecanoylphorbol Acetate	161-186	high mobility group box 1	Homo sapiens	211-216
19366707-6	2009	The suppressive effect of NPM on p53 mitochondrial localization is also observed in TPA-treated primary epithelial cells and in JB6 cells treated with doxorubicin.	Tetradecanoylphorbol Acetate	84-87	nucleophosmin 1	Homo sapiens	26-29
19366707-10	2009	Furthermore, suppression of NPM in tumor cells with a high constitutive level of NPM results in p53 translocation to mitochondria and enhances TPA-mediated apoptosis.	Tetradecanoylphorbol Acetate	143-146	nucleophosmin 1	Homo sapiens	28-31
19366707-10	2009	Furthermore, suppression of NPM in tumor cells with a high constitutive level of NPM results in p53 translocation to mitochondria and enhances TPA-mediated apoptosis.	Tetradecanoylphorbol Acetate	143-146	nucleophosmin 1	Homo sapiens	81-84
19919521-8	2009	By contrast, only a treatment with PMA (80 nM) induced Ang1 release.	Tetradecanoylphorbol Acetate	35-38	angiopoietin 1	Homo sapiens	55-59
19470241-4	2009	The activity and protein expression of ODC in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced colon cancer cells was inhibited by the extract.	Tetradecanoylphorbol Acetate	46-82	ornithine decarboxylase 1	Homo sapiens	39-42
19760383-7	2009	BITC also inhibited ear edema formation and the protein expression of iNOS and COX-2 in mouse skin treated with TPA.	Tetradecanoylphorbol Acetate	112-115	cytochrome c oxidase II, mitochondrial	Mus musculus	79-84
19855090-3	2009	In contrast, we show here that in these and other cells, IGF-IR overexpression reduced the constitutive and phorbol 12-myristate 13-acetate (PMA)-inducible expression of three protein kinase C (PKC)-regulated metalloproteinases, MMP-3, MMP-9, and MMP-13, in cultured cells as well as in vivo in sc tumors.	Tetradecanoylphorbol Acetate	108-139	matrix metallopeptidase 9	Mus musculus	236-241
19855090-3	2009	In contrast, we show here that in these and other cells, IGF-IR overexpression reduced the constitutive and phorbol 12-myristate 13-acetate (PMA)-inducible expression of three protein kinase C (PKC)-regulated metalloproteinases, MMP-3, MMP-9, and MMP-13, in cultured cells as well as in vivo in sc tumors.	Tetradecanoylphorbol Acetate	108-139	matrix metallopeptidase 13	Mus musculus	247-253
19855090-3	2009	In contrast, we show here that in these and other cells, IGF-IR overexpression reduced the constitutive and phorbol 12-myristate 13-acetate (PMA)-inducible expression of three protein kinase C (PKC)-regulated metalloproteinases, MMP-3, MMP-9, and MMP-13, in cultured cells as well as in vivo in sc tumors.	Tetradecanoylphorbol Acetate	141-144	matrix metallopeptidase 9	Mus musculus	236-241
19855090-3	2009	In contrast, we show here that in these and other cells, IGF-IR overexpression reduced the constitutive and phorbol 12-myristate 13-acetate (PMA)-inducible expression of three protein kinase C (PKC)-regulated metalloproteinases, MMP-3, MMP-9, and MMP-13, in cultured cells as well as in vivo in sc tumors.	Tetradecanoylphorbol Acetate	141-144	matrix metallopeptidase 13	Mus musculus	247-253
19470241-4	2009	The activity and protein expression of ODC in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced colon cancer cells was inhibited by the extract.	Tetradecanoylphorbol Acetate	84-87	ornithine decarboxylase 1	Homo sapiens	39-42
19466848-2	2009	Diamond transforms to a mechanically stable cubic structure (P4(1)32) at 2.5 TPa and 300 K. At 4000 K and 2 TPa, simple cubic carbon SC1 (Pm-3m) is obtained from cubic diamond.	Tetradecanoylphorbol Acetate	108-111	transcription factor 19	Homo sapiens	133-136
19887558-5	2009	Cotreatment with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, dramatically inhibited the HDACi-mediated increase in FADD recruitment and sensitization to TRAIL-induced apoptosis and both of these were reversed by PKC inhibitors.	Tetradecanoylphorbol Acetate	17-48	protein kinase C beta	Homo sapiens	76-79
19887558-5	2009	Cotreatment with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, dramatically inhibited the HDACi-mediated increase in FADD recruitment and sensitization to TRAIL-induced apoptosis and both of these were reversed by PKC inhibitors.	Tetradecanoylphorbol Acetate	17-48	protein kinase C beta	Homo sapiens	243-246
19887558-5	2009	Cotreatment with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, dramatically inhibited the HDACi-mediated increase in FADD recruitment and sensitization to TRAIL-induced apoptosis and both of these were reversed by PKC inhibitors.	Tetradecanoylphorbol Acetate	50-53	protein kinase C beta	Homo sapiens	76-79
19887558-5	2009	Cotreatment with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, dramatically inhibited the HDACi-mediated increase in FADD recruitment and sensitization to TRAIL-induced apoptosis and both of these were reversed by PKC inhibitors.	Tetradecanoylphorbol Acetate	50-53	protein kinase C beta	Homo sapiens	243-246
19435896-1	2009	Our previous findings indicated that RSK2 plays a critical role in proliferation and cell transformation induced by tumor promoters, such as epidermal growth factor or 12-O-tetradecanoylphorbol-13-acetate, and that kaempferol, a natural compound found in edible plants, selectively inhibits RSK2 activity.	Tetradecanoylphorbol Acetate	168-204	ribosomal protein S6 kinase A3	Homo sapiens	37-41
19279008-3	2009	Inhibition of ceramide formation by fumonisin B1 or down-regulation of PKCdelta potentiated PMA-induced activation of p38 in human breast cancer MCF-7 cells.	Tetradecanoylphorbol Acetate	92-95	protein kinase C delta	Homo sapiens	71-79
19693770-3	2009	To further investigate the correlation between MMP-2 and protein kinase C alpha (PKC alpha), the expression of MMP-2 in the 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated organotypic culture of decidual tissue was determined.	Tetradecanoylphorbol Acetate	124-160	matrix metallopeptidase 2	Rattus norvegicus	111-116
19693770-3	2009	To further investigate the correlation between MMP-2 and protein kinase C alpha (PKC alpha), the expression of MMP-2 in the 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated organotypic culture of decidual tissue was determined.	Tetradecanoylphorbol Acetate	162-165	matrix metallopeptidase 2	Rattus norvegicus	111-116
19340542-9	2009	Treatment with the ERK1/2 inhibitor, PD98059 (10 microM), or the p38 MAPK-specific inhibitor, SB203580 (10 microM), greatly inhibited the E2-induced ER increase, while the protein kinase C (PKC) activator TPA (1 microM) enhanced it.	Tetradecanoylphorbol Acetate	205-208	mitogen-activated protein kinase 3	Mus musculus	19-25
19693770-4	2009	The results showed that the active form of MMP-2 was significantly increased in the TPA-treated cultures.	Tetradecanoylphorbol Acetate	84-87	matrix metallopeptidase 2	Rattus norvegicus	43-48
19693770-6	2009	In addition, TPA also reversed the MMP-2 expression after by progesterone pretreatment in the primary decidual cells.	Tetradecanoylphorbol Acetate	13-16	matrix metallopeptidase 2	Rattus norvegicus	35-40
19340542-9	2009	Treatment with the ERK1/2 inhibitor, PD98059 (10 microM), or the p38 MAPK-specific inhibitor, SB203580 (10 microM), greatly inhibited the E2-induced ER increase, while the protein kinase C (PKC) activator TPA (1 microM) enhanced it.	Tetradecanoylphorbol Acetate	205-208	mitogen-activated protein kinase 14	Mus musculus	65-68
19232538-2	2009	Induction of THP-1 monocyte differentiation by phorbol 12-myristate 13-acetate (PMA) markedly increased SVCT2 mRNA, protein, and function.	Tetradecanoylphorbol Acetate	47-78	solute carrier family 23 member 2	Homo sapiens	104-109
19661060-4	2009	TRPV4 channel activation and serine phosphorylation were enhanced by exposure to the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate or by application of bradykinin, which activates PKC via a G-protein-coupled mechanism.	Tetradecanoylphorbol Acetate	118-149	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
19232538-2	2009	Induction of THP-1 monocyte differentiation by phorbol 12-myristate 13-acetate (PMA) markedly increased SVCT2 mRNA, protein, and function.	Tetradecanoylphorbol Acetate	80-83	solute carrier family 23 member 2	Homo sapiens	104-109
19666776-1	2009	The proenzyme single-chain urokinase plasminogen activator (scuPA) more effectively resolved intrapleural loculations in rabbits with tetracycline (TCN)-induced loculation than a range of clinical doses of two-chain uPA (Abbokinase) and demonstrated a trend toward greater efficacy than single-chain tPA (Activase) (Idell S et al., Exp Lung Res 33: 419, 2007.).	Tetradecanoylphorbol Acetate	300-303	urokinase-type plasminogen activator	Oryctolagus cuniculus	62-65
19232538-3	2009	When ascorbate was present during PMA-induced differentiation, the increase in SVCT2 protein expression was inhibited, but differentiation was enhanced.	Tetradecanoylphorbol Acetate	34-37	solute carrier family 23 member 2	Homo sapiens	79-84
19232538-4	2009	PMA-induced SVCT2 protein expression was blocked by inhibitors of protein kinase C (PKC), with most of the affect due to the PKCbetaI and betaII isoforms.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 23 member 2	Homo sapiens	12-17
19232538-8	2009	In conclusion, PMA-induced monocyte-macrophage differentiation is enhanced by ascorbate and associated with increased expression and function of the SVCT2 protein through a pathway involving sustained activation of PKCbetaI/II, MAP kinase, NADPH oxidase, and NF-kappaB.	Tetradecanoylphorbol Acetate	15-18	solute carrier family 23 member 2	Homo sapiens	149-154
19176526-6	2009	In contrast, phorbol 12-myristate 13-acetate induced low amplitude calcium oscillations, slower translocation of cPLA(2)alpha to Golgi, and much less AA release, which were blocked by chelating extracellular calcium.	Tetradecanoylphorbol Acetate	13-44	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	113-125
19420332-3	2009	Changes of expression of MMP-2 and MMP-9 of fibroblasts after the simulation of a standard PKC activator, 2-O-tetradecanoyl-phorbol-13-acetate (TPA), were studied.	Tetradecanoylphorbol Acetate	144-147	matrix metallopeptidase 2	Homo sapiens	25-30
19420332-7	2009	TPA stimulated the expression of MMP-2 and MMP-9 by pterygium fibroblasts isolated from early-stage specimens in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 2	Homo sapiens	33-38
19309000-8	2009	Bcl-x(L)-deficient mice were more resistant than wild-type controls to skin tumor development with delayed onset and reduced number of tumors using either UVB or the DMBA/TPA two-stage regimen.	Tetradecanoylphorbol Acetate	171-174	BCL2-like 1	Mus musculus	0-8
19414379-1	2009	During 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of human promyelocytic leukemia HL-60 cells toward maturing monocytes/macrophages, asparagine synthetase (ASNS) mRNA expression declined time and dose-dependently.	Tetradecanoylphorbol Acetate	7-43	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	157-178
19414379-1	2009	During 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of human promyelocytic leukemia HL-60 cells toward maturing monocytes/macrophages, asparagine synthetase (ASNS) mRNA expression declined time and dose-dependently.	Tetradecanoylphorbol Acetate	7-43	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	180-184
19414379-1	2009	During 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of human promyelocytic leukemia HL-60 cells toward maturing monocytes/macrophages, asparagine synthetase (ASNS) mRNA expression declined time and dose-dependently.	Tetradecanoylphorbol Acetate	45-48	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	157-178
19414379-1	2009	During 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of human promyelocytic leukemia HL-60 cells toward maturing monocytes/macrophages, asparagine synthetase (ASNS) mRNA expression declined time and dose-dependently.	Tetradecanoylphorbol Acetate	45-48	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	180-184
19467228-5	2009	EPCR shedding was also induced by phorbol 12-myristate 13-acetate, ionomycin, anisomycin, thiol oxidants or alkylators, thrombin, and disruptors of lipid rafts.	Tetradecanoylphorbol Acetate	34-65	protein C receptor	Homo sapiens	0-4
19414379-4	2009	These data suggest the possible involvement of MEK1/2 MAPK in the inhibitory effect of TPA on ASNS mRNA expression and that the induction of the down-regulation of ASNS (via MEK1/2 activation) may be a new strategy for the treatment of leukemia blast cells.	Tetradecanoylphorbol Acetate	87-90	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	94-98
19302816-6	2009	After treatment of these two cell types with phorbol 12-myristate 13-acetate (PMA) for 48 h, cells with reduced Nm23-H1 expression had a higher percentage of 8N ploidy and higher expression of CD41 than K562 cells overexpressing Nm23-H1.	Tetradecanoylphorbol Acetate	45-76	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	112-119
19701239-7	2009	BIMI (a PKC inhibitor) prevented the effects of PMA (a PKC activator) on the KCNQ4 current, indicating that PKC may be involved in the regulation of KCNQ4 expressed in the Xenopus oocyte system.	Tetradecanoylphorbol Acetate	48-51	potassium voltage-gated channel subfamily Q member 4	Homo sapiens	77-82
19701239-7	2009	BIMI (a PKC inhibitor) prevented the effects of PMA (a PKC activator) on the KCNQ4 current, indicating that PKC may be involved in the regulation of KCNQ4 expressed in the Xenopus oocyte system.	Tetradecanoylphorbol Acetate	48-51	potassium voltage-gated channel subfamily Q member 4	Homo sapiens	149-154
19302816-6	2009	After treatment of these two cell types with phorbol 12-myristate 13-acetate (PMA) for 48 h, cells with reduced Nm23-H1 expression had a higher percentage of 8N ploidy and higher expression of CD41 than K562 cells overexpressing Nm23-H1.	Tetradecanoylphorbol Acetate	45-76	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	229-236
19302816-6	2009	After treatment of these two cell types with phorbol 12-myristate 13-acetate (PMA) for 48 h, cells with reduced Nm23-H1 expression had a higher percentage of 8N ploidy and higher expression of CD41 than K562 cells overexpressing Nm23-H1.	Tetradecanoylphorbol Acetate	78-81	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	112-119
19413996-3	2009	The results showed that, whereas the PKC activator phorbol-12-myristate-13-acetate (PMA) activated every PKC tested except aPKC, coleon U had no effect on aPKC and cPKCs.	Tetradecanoylphorbol Acetate	51-82	protein kinase C delta	Homo sapiens	37-40
19302816-6	2009	After treatment of these two cell types with phorbol 12-myristate 13-acetate (PMA) for 48 h, cells with reduced Nm23-H1 expression had a higher percentage of 8N ploidy and higher expression of CD41 than K562 cells overexpressing Nm23-H1.	Tetradecanoylphorbol Acetate	78-81	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	229-236
19413996-3	2009	The results showed that, whereas the PKC activator phorbol-12-myristate-13-acetate (PMA) activated every PKC tested except aPKC, coleon U had no effect on aPKC and cPKCs.	Tetradecanoylphorbol Acetate	51-82	protein kinase C delta	Homo sapiens	105-108
19413996-3	2009	The results showed that, whereas the PKC activator phorbol-12-myristate-13-acetate (PMA) activated every PKC tested except aPKC, coleon U had no effect on aPKC and cPKCs.	Tetradecanoylphorbol Acetate	84-87	protein kinase C delta	Homo sapiens	37-40
19136660-3	2009	When the human erythroleukemia (HEL) cell line is induced to differentiate with 12-O-tetradecanoylphorbol 13-acetate, overexpression of MKL1 results in an increased number of megakaryocytes with a concurrent increase in ploidy.	Tetradecanoylphorbol Acetate	80-116	myocardin related transcription factor A	Homo sapiens	136-140
19413996-3	2009	The results showed that, whereas the PKC activator phorbol-12-myristate-13-acetate (PMA) activated every PKC tested except aPKC, coleon U had no effect on aPKC and cPKCs.	Tetradecanoylphorbol Acetate	84-87	protein kinase C delta	Homo sapiens	105-108
19507195-4	2009	The results showed that PAB dose-dependently suppressed human T lymphocyte proliferation, IL-2 production and CD25 expression induced by co-stimulation of PMA plus ionomycin or of anti-OKT-3 plus anti-CD28.	Tetradecanoylphorbol Acetate	155-158	interleukin 2 receptor subunit alpha	Homo sapiens	110-114
19195490-4	2009	We also designed a chimera that had an additional N-terminal TPA leader sequence (pTPA.GPI-PA63) with an aim to target GPI-PA63 to ER where new CD1 molecules are synthesized.	Tetradecanoylphorbol Acetate	61-64	glucose-6-phosphate isomerase	Homo sapiens	87-90
19409374-5	2009	Moreover, the genetic blockage of iNOS signaling inhibited the TPA-induced ERK and p38 activation resulting in reduced COX-2 upregulation.	Tetradecanoylphorbol Acetate	63-66	mitogen-activated protein kinase 14	Mus musculus	83-86
19409374-5	2009	Moreover, the genetic blockage of iNOS signaling inhibited the TPA-induced ERK and p38 activation resulting in reduced COX-2 upregulation.	Tetradecanoylphorbol Acetate	63-66	cytochrome c oxidase II, mitochondrial	Mus musculus	119-124
19617683-1	2009	We have identified two polymorphs of the molecular complex [(TPA)Fe((III))(TCC)]PF(6) [TPA = tris(2-pyridylmethyl)amine and TCC = 3,4,5,6-tetrachlorocatecholate dianion]: one is monoclinic and the other is orthorhombic.	Tetradecanoylphorbol Acetate	61-64	sperm associated antigen 17	Homo sapiens	80-85
19335688-5	2009	Furthermore, the enhanced expression of CD208 in the perinuclear lesions of IFN-gamma-/TPA-stimulated keratinocytes was observed in vitro.	Tetradecanoylphorbol Acetate	87-90	lysosomal associated membrane protein 3	Homo sapiens	40-45
19458037-2	2009	We previously demonstrated that phospholipase C (PLC)epsilon, an effector of Ras and Rap small GTPases, plays a crucial role in two-stage skin chemical carcinogenesis using 12-O-tetradecanoyl-phorbor-13-acetate (TPA) as a promoter through augmentation of TPA-induced inflammation.	Tetradecanoylphorbol Acetate	255-258	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	49-52
18756441-2	2009	We have recently shown that treatment of LNCaP cells with phorbol 12-myristate 13-acetate (PMA) leads to a PKCdelta-mediated autocrine release of death factors, including the cytokines TNFalpha and TRAIL, and that conditioned medium (CM) collected from PMA-treated LNCaP cells promotes the activation of the extrinsic apoptotic cascade.	Tetradecanoylphorbol Acetate	58-89	protein kinase C delta	Homo sapiens	107-115
18756441-2	2009	We have recently shown that treatment of LNCaP cells with phorbol 12-myristate 13-acetate (PMA) leads to a PKCdelta-mediated autocrine release of death factors, including the cytokines TNFalpha and TRAIL, and that conditioned medium (CM) collected from PMA-treated LNCaP cells promotes the activation of the extrinsic apoptotic cascade.	Tetradecanoylphorbol Acetate	91-94	protein kinase C delta	Homo sapiens	107-115
19633700-4	2009	PKC activator phorbol-12-myristate-13-acetate (PMA, 100 nmol/L) was also used in this study.	Tetradecanoylphorbol Acetate	14-45	protein kinase C, delta	Rattus norvegicus	0-3
19212645-3	2009	Cytokines and signal transduction pathways, including those activated by phorbol 12-myristate 13-acetate (PMA), regulate the expression of MMPs.	Tetradecanoylphorbol Acetate	73-104	matrix metallopeptidase 2	Homo sapiens	139-143
19212645-3	2009	Cytokines and signal transduction pathways, including those activated by phorbol 12-myristate 13-acetate (PMA), regulate the expression of MMPs.	Tetradecanoylphorbol Acetate	106-109	matrix metallopeptidase 2	Homo sapiens	139-143
19164581-4	2009	After exposure of cells to the AP-1 agonist 12-O-tetradecanoylphorbol-13-acetate (TPA), CRTC1 is recruited to AP-1 target gene promoters and associates with c-Jun and c-Fos to activate transcription.	Tetradecanoylphorbol Acetate	44-80	CREB regulated transcription coactivator 1	Homo sapiens	88-93
19372459-2	2009	METHODS AND RESULTS: Effects of selected cytokines and growth factors on megakaryocyte expression of FcgammaRIIa were assessed with phorbol 12-myristate 13-acetate (PMA)-differentiated human erythroleukemia (HEL) cells and with thrombopoietin-differentiated CD34 stem cells and compared with those obtained with myelocytic cell lines and a monocytic cell lines.	Tetradecanoylphorbol Acetate	132-163	Fc gamma receptor IIa	Homo sapiens	101-112
19372459-2	2009	METHODS AND RESULTS: Effects of selected cytokines and growth factors on megakaryocyte expression of FcgammaRIIa were assessed with phorbol 12-myristate 13-acetate (PMA)-differentiated human erythroleukemia (HEL) cells and with thrombopoietin-differentiated CD34 stem cells and compared with those obtained with myelocytic cell lines and a monocytic cell lines.	Tetradecanoylphorbol Acetate	165-168	Fc gamma receptor IIa	Homo sapiens	101-112
19181503-0	2009	Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	19-22	zinc fingers and homeoboxes 2	Homo sapiens	90-93
19164581-4	2009	After exposure of cells to the AP-1 agonist 12-O-tetradecanoylphorbol-13-acetate (TPA), CRTC1 is recruited to AP-1 target gene promoters and associates with c-Jun and c-Fos to activate transcription.	Tetradecanoylphorbol Acetate	82-85	CREB regulated transcription coactivator 1	Homo sapiens	88-93
19432991-8	2009	The counter-regulated genes have been clustered into functional categories and bioinformatic analysis has identified the B-Raf/Mek/Erk branch of the MAP kinase pathway as one containing several genes whose upregulation by TPA is blocked by ATRA.	Tetradecanoylphorbol Acetate	222-225	midkine	Mus musculus	127-130
19135902-5	2009	The transferrin receptor 1(TfR-1; CD71), whose surface expression is downregulated during TPA-mediated HL-60 cell differentiation, has been identified as a target of the TPA-induced miRNA miR-320.	Tetradecanoylphorbol Acetate	90-93	transferrin receptor	Homo sapiens	27-32
19135902-5	2009	The transferrin receptor 1(TfR-1; CD71), whose surface expression is downregulated during TPA-mediated HL-60 cell differentiation, has been identified as a target of the TPA-induced miRNA miR-320.	Tetradecanoylphorbol Acetate	90-93	transferrin receptor	Homo sapiens	34-38
19140803-3	2009	Incubation of isolated rat alveolar type II cells (AECII) with PMA, a PKC (protein kinase C) agonist, had no effect on Prdx6 expression but led to approximately 75% increase in aiPLA(2) activity that was abolished by pretreatment of cells with the MAPK (mitogen-activated protein kinase) inhibitors, SB202190 or PD98059.	Tetradecanoylphorbol Acetate	63-66	peroxiredoxin 6	Rattus norvegicus	177-185
19135902-5	2009	The transferrin receptor 1(TfR-1; CD71), whose surface expression is downregulated during TPA-mediated HL-60 cell differentiation, has been identified as a target of the TPA-induced miRNA miR-320.	Tetradecanoylphorbol Acetate	170-173	transferrin receptor	Homo sapiens	27-32
19135902-5	2009	The transferrin receptor 1(TfR-1; CD71), whose surface expression is downregulated during TPA-mediated HL-60 cell differentiation, has been identified as a target of the TPA-induced miRNA miR-320.	Tetradecanoylphorbol Acetate	170-173	transferrin receptor	Homo sapiens	34-38
19135902-7	2009	CONCLUSION: TPA induces the expression of several miRNAs in HL-60 cells, one such miRNA (miR-320) contributes to downregulation of TfR-1 surface expression characteristically seen during HL-60 monocytic differentiation.	Tetradecanoylphorbol Acetate	12-15	transferrin receptor	Homo sapiens	131-136
19033444-7	2009	Analysis of the channel function demonstrated a crucial role of the N-terminal tyrosine residue in the activation of TRPV4 by heat, mechanical (shear) stress, hypotonic cell swelling, and phorbol 12-myristate 13-acetate, but not in the activation by synthetic ligand 4alpha-phorbol 12,13-didecanoate.	Tetradecanoylphorbol Acetate	188-219	transient receptor potential cation channel subfamily V member 4	Homo sapiens	117-122
19383924-3	2009	In this study, we examined the requirement for Mek1 and Mek2 in skin neoplasia using the two-step 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA) skin carcinogenesis model.	Tetradecanoylphorbol Acetate	129-165	mitogen-activated protein kinase kinase 1	Mus musculus	47-51
19383924-4	2009	Mice lacking epidermal Mek1 protein develop fewer papillomas than both wild-type and Mek2-null mice following DMBA/TPA treatment.	Tetradecanoylphorbol Acetate	115-118	mitogen-activated protein kinase kinase 1	Mus musculus	23-27
19220020-10	2009	HEK293 cells harboring the PDP1 siRNA construct also displayed a marked decrease in the extent of PMA-initiated conversion of cellular PSDP to PSMP.	Tetradecanoylphorbol Acetate	98-101	microseminoprotein, prostate associated	Homo sapiens	143-147
19033444-8	2009	Furthermore, the response of TRPV4 to phorbol 12-myristate 13-acetate was SFK-dependent.	Tetradecanoylphorbol Acetate	38-69	transient receptor potential cation channel subfamily V member 4	Homo sapiens	29-34
18848748-3	2009	Pretreatment of mouse skin with oligonol significantly inhibited TPA-induced expression of cyclooxygenase-2 (COX-2).	Tetradecanoylphorbol Acetate	65-68	prostaglandin-endoperoxide synthase 2	Mus musculus	91-107
19019167-10	2009	Epidermal growth factor (50 ng/mL) and phorbol 12-myristate 13-acetate (10(-7) mol/L) stimulated the secretion of soluble EMMPRIN and increased the MMP-2 activity, although these agents did not increase the level of EMMPRIN mRNA.	Tetradecanoylphorbol Acetate	39-70	matrix metallopeptidase 2	Homo sapiens	148-153
18848748-3	2009	Pretreatment of mouse skin with oligonol significantly inhibited TPA-induced expression of cyclooxygenase-2 (COX-2).	Tetradecanoylphorbol Acetate	65-68	prostaglandin-endoperoxide synthase 2	Mus musculus	109-114
18848748-5	2009	Moreover, oligonol suppressed TPA-induced DNA binding of CCAAT/enhancer-binding protein (C/EBP) in mouse skin.	Tetradecanoylphorbol Acetate	30-33	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	57-87
19252277-0	2009	Gene expression analysis during platelet-like particle production in phorbol myristate acetate-treated MEG-01 cells.	Tetradecanoylphorbol Acetate	69-94	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	103-106
18848748-5	2009	Moreover, oligonol suppressed TPA-induced DNA binding of CCAAT/enhancer-binding protein (C/EBP) in mouse skin.	Tetradecanoylphorbol Acetate	30-33	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	89-94
18848748-7	2009	Moreover, p38 MAP kinase inhibitor SB203580, but not the MEK inhibitor U0126, negated TPA-induced DNA binding of C/EBP.	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase 14	Mus musculus	10-13
18848748-7	2009	Moreover, p38 MAP kinase inhibitor SB203580, but not the MEK inhibitor U0126, negated TPA-induced DNA binding of C/EBP.	Tetradecanoylphorbol Acetate	86-89	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	113-118
19364320-2	2009	The expression of CD69 molecules on the surface of T-cells depended only on the presence of phorbol myristate acetate, occurred at [Ca2+]e higher than 0.2 mM, and did not require the presence of ionomycin.	Tetradecanoylphorbol Acetate	92-117	CD69 molecule	Homo sapiens	18-22
18848748-10	2009	Taken together, the above findings suggest that oligonol inhibits TPA-induced COX-2 expression by blocking the activation of NF-kappaB and C/EBP via modulation of MAP kinases and suppresses chemically induced mouse skin tumorigenesis.	Tetradecanoylphorbol Acetate	66-69	prostaglandin-endoperoxide synthase 2	Mus musculus	78-83
18848748-10	2009	Taken together, the above findings suggest that oligonol inhibits TPA-induced COX-2 expression by blocking the activation of NF-kappaB and C/EBP via modulation of MAP kinases and suppresses chemically induced mouse skin tumorigenesis.	Tetradecanoylphorbol Acetate	66-69	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	139-144
18931473-3	2009	In the present study, focusing mainly on PKC epsilon, the mechanisms underlying the proteasome-dependent downregulation of GnRH-activated PKC epsilon and TPA-sensitive PKC alpha and epsilon isoenzymes were investigated in alphaT3-1 gonadotrope cells.	Tetradecanoylphorbol Acetate	154-157	protein kinase C, epsilon	Mus musculus	41-52
19155301-9	2009	Finally, we show that OPN is expressed in senescent stroma within preneoplastic lesions that arise following 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate treatment of mice, suggesting that stromal-derived OPN-mediated signaling events affect neoplastic progression.	Tetradecanoylphorbol Acetate	140-176	secreted phosphoprotein 1	Mus musculus	22-25
18950637-1	2008	The ubiquitous activating transcription factor (ATF) 7 binds as a homodimer to the cAMP response element/TPA response element motifs present in the promoters of its target genes.	Tetradecanoylphorbol Acetate	105-108	activating transcription factor 7	Homo sapiens	15-54
18929613-8	2008	In addition, we performed experiments with the rat hepatic stellate cell line HSC-T6 in which we induced the expression of MMP-2 and alpha-SMA with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	148-179	matrix metallopeptidase 2	Rattus norvegicus	123-128
18818290-8	2009	Furthermore, both insulin-induced GLP-1 release and secretion in response to glucose-dependent insulinotropic peptide and phorbol-12-myristate-13-acetate were significantly attenuated.	Tetradecanoylphorbol Acetate	122-153	glucagon	Mus musculus	34-39
18929613-8	2008	In addition, we performed experiments with the rat hepatic stellate cell line HSC-T6 in which we induced the expression of MMP-2 and alpha-SMA with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	181-184	matrix metallopeptidase 2	Rattus norvegicus	123-128
18930149-5	2009	Consistently, the totality of striatal neurons responded to capsaicin (10 nM or 10 microM) after prevention of desensitization of TRPV1 channels with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	187-218	transient receptor potential cation channel subfamily V member 1	Homo sapiens	130-135
18981301-4	2008	METHODS AND RESULTS: The differentiation of human primary monocytes or the monocytic THP-1 cell line into monocyte-derived macrophages was induced by phorbol 12-myristate 13-acetate (PMA; 0.1 mmol/L), a potent activator of PKC.	Tetradecanoylphorbol Acetate	183-186	protein kinase C beta	Homo sapiens	223-226
18930149-5	2009	Consistently, the totality of striatal neurons responded to capsaicin (10 nM or 10 microM) after prevention of desensitization of TRPV1 channels with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	220-223	transient receptor potential cation channel subfamily V member 1	Homo sapiens	130-135
18930149-7	2009	The effects of capsaicin and of PMA were absent after pharmacological or genetic inactivation of TRPV1 channels.	Tetradecanoylphorbol Acetate	32-35	transient receptor potential cation channel subfamily V member 1	Homo sapiens	97-102
18755854-3	2008	MA-10 mouse Leydig tumor cells treated with an activator of PRKCC, phorbol 12-myristate 13-acetate (PMA), demonstrated increases in the expression of the STAR and CYP11A1 proteins and progesterone synthesis, which coincided with the expression and phosphorylation of JUN (P-JUN).	Tetradecanoylphorbol Acetate	67-98	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	163-170
18755854-3	2008	MA-10 mouse Leydig tumor cells treated with an activator of PRKCC, phorbol 12-myristate 13-acetate (PMA), demonstrated increases in the expression of the STAR and CYP11A1 proteins and progesterone synthesis, which coincided with the expression and phosphorylation of JUN (P-JUN).	Tetradecanoylphorbol Acetate	100-103	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	163-170
18755689-6	2008	Phorbol 12-myristate 13-acetate overcame the inhibitory effect of P2Y12 receptor blockade on PKC activation but not on Rap1b activation and platelet aggregation.	Tetradecanoylphorbol Acetate	0-31	purinergic receptor P2Y12	Homo sapiens	66-71
18703509-4	2008	Overexpression of constitutively active PKD or PKD activation by treatment with phorbol 12-myristate 13-acetate results in phosphorylation of two serine residues (Ser5 and Ser87) in a form of Bit1 that is confined to the cytoplasm and concomitantly increases the apoptotic activity of cytoplasmic Bit1.	Tetradecanoylphorbol Acetate	80-111	peptidyl-tRNA hydrolase 2	Homo sapiens	192-196
18703509-4	2008	Overexpression of constitutively active PKD or PKD activation by treatment with phorbol 12-myristate 13-acetate results in phosphorylation of two serine residues (Ser5 and Ser87) in a form of Bit1 that is confined to the cytoplasm and concomitantly increases the apoptotic activity of cytoplasmic Bit1.	Tetradecanoylphorbol Acetate	80-111	peptidyl-tRNA hydrolase 2	Homo sapiens	297-301
18581203-4	2008	AVP also activated extracellular signal-regulated kinase 1/2 (ERK1/2) as assessed by MBP phosphotransferase activity (5.1 +/- 0.6 fold over basal level, P &lt; or = 0.05) and Western blot analysis, and effects were mimicked by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but abolished by inhibiting cellular PKC through chronic PMA incubation.	Tetradecanoylphorbol Acetate	261-292	mitogen activated protein kinase 3	Rattus norvegicus	19-60
18581203-4	2008	AVP also activated extracellular signal-regulated kinase 1/2 (ERK1/2) as assessed by MBP phosphotransferase activity (5.1 +/- 0.6 fold over basal level, P &lt; or = 0.05) and Western blot analysis, and effects were mimicked by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but abolished by inhibiting cellular PKC through chronic PMA incubation.	Tetradecanoylphorbol Acetate	261-292	mitogen activated protein kinase 3	Rattus norvegicus	62-68
18581203-4	2008	AVP also activated extracellular signal-regulated kinase 1/2 (ERK1/2) as assessed by MBP phosphotransferase activity (5.1 +/- 0.6 fold over basal level, P &lt; or = 0.05) and Western blot analysis, and effects were mimicked by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but abolished by inhibiting cellular PKC through chronic PMA incubation.	Tetradecanoylphorbol Acetate	294-297	mitogen activated protein kinase 3	Rattus norvegicus	19-60
18581203-4	2008	AVP also activated extracellular signal-regulated kinase 1/2 (ERK1/2) as assessed by MBP phosphotransferase activity (5.1 +/- 0.6 fold over basal level, P &lt; or = 0.05) and Western blot analysis, and effects were mimicked by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but abolished by inhibiting cellular PKC through chronic PMA incubation.	Tetradecanoylphorbol Acetate	294-297	mitogen activated protein kinase 3	Rattus norvegicus	62-68
18499341-2	2008	In this study, we found that CKS reduced 12-O-tetradecanoylphorbol-13-acetate (PMA)-enhanced Matrix metalloproteinases (MMP)-9 and MMP-2 activation in a dose-dependant manner and further inhibited HT-1080 cell invasion and migration.	Tetradecanoylphorbol Acetate	41-77	matrix metallopeptidase 2	Homo sapiens	131-136
18499341-2	2008	In this study, we found that CKS reduced 12-O-tetradecanoylphorbol-13-acetate (PMA)-enhanced Matrix metalloproteinases (MMP)-9 and MMP-2 activation in a dose-dependant manner and further inhibited HT-1080 cell invasion and migration.	Tetradecanoylphorbol Acetate	79-82	matrix metallopeptidase 2	Homo sapiens	131-136
18635599-7	2008	We show that lipid rafts are required for enterocyte migration, that IFN displaces Cx43 from lipid rafts, and that the phorbol ester phorbol 12-myristate 13-acetate (PMA) restores Cx43 to lipid rafts after treatment with IFN in a protein kinase C-dependent manner.	Tetradecanoylphorbol Acetate	133-164	gap junction protein alpha 1	Homo sapiens	180-184
18635599-7	2008	We show that lipid rafts are required for enterocyte migration, that IFN displaces Cx43 from lipid rafts, and that the phorbol ester phorbol 12-myristate 13-acetate (PMA) restores Cx43 to lipid rafts after treatment with IFN in a protein kinase C-dependent manner.	Tetradecanoylphorbol Acetate	166-169	gap junction protein alpha 1	Homo sapiens	180-184
18668201-5	2008	ERalpha and ERbeta interact with NFAT3 independently of the NFAT agonists phorbol myristate acetate (PMA) and ionomycin, and ERalpha is recruited to an NFAT3 target gene promoter.	Tetradecanoylphorbol Acetate	101-104	estrogen receptor 2	Homo sapiens	12-18
18583709-8	2008	Moreover, silencing of cardiomyocyte Hsp25 allowed phorbol 12-myristate 13-acetate to elicit a significant phosphorylation of PKCdelta, an appreciable association between PKCdelta and PKD, and a vigorous activation of PKD.	Tetradecanoylphorbol Acetate	51-82	protein kinase C delta	Homo sapiens	126-134
18583709-8	2008	Moreover, silencing of cardiomyocyte Hsp25 allowed phorbol 12-myristate 13-acetate to elicit a significant phosphorylation of PKCdelta, an appreciable association between PKCdelta and PKD, and a vigorous activation of PKD.	Tetradecanoylphorbol Acetate	51-82	protein kinase C delta	Homo sapiens	171-179
18602101-3	2008	We find here that morphological activation of endothelial cells by phorbol 12-myristate 13-acetate (PMA) resulted in membrane-type 1 matrix metalloproteinase (MT1-MMP) -mediated solubilization of latent TGF-beta complexes from the ECM by proteolytic processing of LTBP-1.	Tetradecanoylphorbol Acetate	67-98	matrix metallopeptidase 14	Homo sapiens	117-157
18602101-3	2008	We find here that morphological activation of endothelial cells by phorbol 12-myristate 13-acetate (PMA) resulted in membrane-type 1 matrix metalloproteinase (MT1-MMP) -mediated solubilization of latent TGF-beta complexes from the ECM by proteolytic processing of LTBP-1.	Tetradecanoylphorbol Acetate	67-98	matrix metallopeptidase 14	Homo sapiens	159-166
18602101-3	2008	We find here that morphological activation of endothelial cells by phorbol 12-myristate 13-acetate (PMA) resulted in membrane-type 1 matrix metalloproteinase (MT1-MMP) -mediated solubilization of latent TGF-beta complexes from the ECM by proteolytic processing of LTBP-1.	Tetradecanoylphorbol Acetate	100-103	matrix metallopeptidase 14	Homo sapiens	117-157
18602101-3	2008	We find here that morphological activation of endothelial cells by phorbol 12-myristate 13-acetate (PMA) resulted in membrane-type 1 matrix metalloproteinase (MT1-MMP) -mediated solubilization of latent TGF-beta complexes from the ECM by proteolytic processing of LTBP-1.	Tetradecanoylphorbol Acetate	100-103	matrix metallopeptidase 14	Homo sapiens	159-166
18534633-0	2008	Hemin inhibits cyclooxygenase-2 expression through nuclear factor-kappa B activation and ornithine decarboxylase expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin.	Tetradecanoylphorbol Acetate	127-163	prostaglandin-endoperoxide synthase 2	Mus musculus	15-31
18436431-9	2008	Furthermore, combined knockdown of PKCdelta and epsilon revealed an increased inhibitory effect on PMA-stimulated NF-kappaB-dependent transcription suggesting that PMA-induced NF-kappaB-dependent transcription is driven by novel PKC isoforms, particularly PKCdelta and epsilon.	Tetradecanoylphorbol Acetate	99-102	protein kinase C delta	Homo sapiens	35-43
18436431-9	2008	Furthermore, combined knockdown of PKCdelta and epsilon revealed an increased inhibitory effect on PMA-stimulated NF-kappaB-dependent transcription suggesting that PMA-induced NF-kappaB-dependent transcription is driven by novel PKC isoforms, particularly PKCdelta and epsilon.	Tetradecanoylphorbol Acetate	99-102	protein kinase C delta	Homo sapiens	35-38
18436431-9	2008	Furthermore, combined knockdown of PKCdelta and epsilon revealed an increased inhibitory effect on PMA-stimulated NF-kappaB-dependent transcription suggesting that PMA-induced NF-kappaB-dependent transcription is driven by novel PKC isoforms, particularly PKCdelta and epsilon.	Tetradecanoylphorbol Acetate	99-102	protein kinase C delta	Homo sapiens	256-264
18436431-9	2008	Furthermore, combined knockdown of PKCdelta and epsilon revealed an increased inhibitory effect on PMA-stimulated NF-kappaB-dependent transcription suggesting that PMA-induced NF-kappaB-dependent transcription is driven by novel PKC isoforms, particularly PKCdelta and epsilon.	Tetradecanoylphorbol Acetate	164-167	protein kinase C delta	Homo sapiens	35-43
18436431-9	2008	Furthermore, combined knockdown of PKCdelta and epsilon revealed an increased inhibitory effect on PMA-stimulated NF-kappaB-dependent transcription suggesting that PMA-induced NF-kappaB-dependent transcription is driven by novel PKC isoforms, particularly PKCdelta and epsilon.	Tetradecanoylphorbol Acetate	164-167	protein kinase C delta	Homo sapiens	35-38
18436431-9	2008	Furthermore, combined knockdown of PKCdelta and epsilon revealed an increased inhibitory effect on PMA-stimulated NF-kappaB-dependent transcription suggesting that PMA-induced NF-kappaB-dependent transcription is driven by novel PKC isoforms, particularly PKCdelta and epsilon.	Tetradecanoylphorbol Acetate	164-167	protein kinase C delta	Homo sapiens	256-264
18177935-10	2008	Therefore, we suggest that ODC inhibits the TNF-alpha-elevated MMP-9 activation via NF-kappaB as TPA-induced macrophage-like differentiation and this interrupting mechanism may provide a new conceivable resolution why leukemia is poorly differentiated besides atypical growth.	Tetradecanoylphorbol Acetate	97-100	ornithine decarboxylase 1	Homo sapiens	27-30
18560723-9	2008	AVP induced an activation of ERK1/2, which could be mimicked by the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA, 30 nmol/L, 5 min), but abolished by depletion of PKC via chronic PMA incubation (2.5 mumol/L, 24 h).	Tetradecanoylphorbol Acetate	102-133	mitogen activated protein kinase 3	Rattus norvegicus	29-35
18560723-9	2008	AVP induced an activation of ERK1/2, which could be mimicked by the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA, 30 nmol/L, 5 min), but abolished by depletion of PKC via chronic PMA incubation (2.5 mumol/L, 24 h).	Tetradecanoylphorbol Acetate	135-138	mitogen activated protein kinase 3	Rattus norvegicus	29-35
18477648-6	2008	In contrast, though curcumin (10 mumol) alone did not alter the basal activity/levels, its pre-treatment decreased the TPA-induced translocation of PKC isozymes (alpha, beta, gamma, epsilon, eta), resulting in appropriate alterations in activity.	Tetradecanoylphorbol Acetate	119-122	endothelin receptor type A	Mus musculus	162-194
18172602-3	2008	In this work, we used the patch-clamp technique to study the effect of phorbol 12-myristate 13-acetate (PMA), a general PKC activator, on the electrical conductance of exogenous Cx43Hc expressed in tsA201 cells.	Tetradecanoylphorbol Acetate	71-102	gap junction protein alpha 1	Homo sapiens	178-182
18172602-3	2008	In this work, we used the patch-clamp technique to study the effect of phorbol 12-myristate 13-acetate (PMA), a general PKC activator, on the electrical conductance of exogenous Cx43Hc expressed in tsA201 cells.	Tetradecanoylphorbol Acetate	104-107	gap junction protein alpha 1	Homo sapiens	178-182
18172602-6	2008	It is interesting to note that intracellular diffusion of epsilon V1-2 (0.1 microM), an epsilon PKC-specific inhibitor peptide, completely antagonized PMA-induced current inhibition.	Tetradecanoylphorbol Acetate	151-154	immunoglobulin lambda variable 2-8	Homo sapiens	66-70
18420182-1	2008	Protein kinase C (PKC) is implicated in the potentiation of Ca v 2.3 currents by acetyl-beta-methylcholine (MCh), a muscarinic M1 receptor agonist or phorbol-12-myristate, 13-acetate (PMA).	Tetradecanoylphorbol Acetate	184-187	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	60-68
18420182-7	2008	PMA-induced potentiation of Ca v 2.3 currents was inhibited by CG533 53, a PKC betaII antagonist, betaIIV5.3, a peptide translocation inhibitor of PKC betaII or PKC betaII siRNA.	Tetradecanoylphorbol Acetate	0-3	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	28-36
18420182-11	2008	Our results implicate PKC alpha in the potentiation of Ca v 2.3 currents by MCh and PKC betaII and epsilon in the potentiation of Ca v 2.3 currents by PMA.	Tetradecanoylphorbol Acetate	151-154	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	55-63
18420182-11	2008	Our results implicate PKC alpha in the potentiation of Ca v 2.3 currents by MCh and PKC betaII and epsilon in the potentiation of Ca v 2.3 currents by PMA.	Tetradecanoylphorbol Acetate	151-154	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	130-138
18059331-2	2008	Deletion of the p19/Arf or p53 tumor suppressor genes accelerates malignant progression and metastatic spread of 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced squamous cell carcinomas, providing a model system to address mechanisms of metastasis.	Tetradecanoylphorbol Acetate	151-188	interleukin 23, alpha subunit p19	Mus musculus	16-19
18059331-2	2008	Deletion of the p19/Arf or p53 tumor suppressor genes accelerates malignant progression and metastatic spread of 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced squamous cell carcinomas, providing a model system to address mechanisms of metastasis.	Tetradecanoylphorbol Acetate	190-193	interleukin 23, alpha subunit p19	Mus musculus	16-19
18223028-5	2008	In this study, we demonstrate the presence of ACE2 as an ectoenzyme and reveal that ACE2 undergoes phorbol-12-myristate-13-acetate-inducible ectodomain shedding from the membrane.	Tetradecanoylphorbol Acetate	99-130	angiotensin converting enzyme 2	Homo sapiens	46-50
18223028-5	2008	In this study, we demonstrate the presence of ACE2 as an ectoenzyme and reveal that ACE2 undergoes phorbol-12-myristate-13-acetate-inducible ectodomain shedding from the membrane.	Tetradecanoylphorbol Acetate	99-130	angiotensin converting enzyme 2	Homo sapiens	84-88
18325701-7	2008	RESULTS: HcFs inhibited the expression of IL-4 and IL-5 in response to phorbol 12-myristate 13-acetate (PMA) and calcium ionophore (CaI) in Jurkat T cells and the human mast cell line, HMC-1.	Tetradecanoylphorbol Acetate	71-102	interleukin 5	Homo sapiens	51-55
18325701-7	2008	RESULTS: HcFs inhibited the expression of IL-4 and IL-5 in response to phorbol 12-myristate 13-acetate (PMA) and calcium ionophore (CaI) in Jurkat T cells and the human mast cell line, HMC-1.	Tetradecanoylphorbol Acetate	104-107	interleukin 5	Homo sapiens	51-55
18291120-3	2008	Treatment of human umbilical vein endothelial cells (HUVEC) and HUVEC-derived EA.hy 926 endothelial cells with phorbol 12-myristate 13-acetate (PMA) or phorbol 12,13-dibutyrate led to a PKC-dependent biphasic expression of the gp91phox homolog Nox4.	Tetradecanoylphorbol Acetate	111-142	NADPH oxidase 4	Homo sapiens	244-248
18223161-9	2008	Phorbol 12-myristate 13-acetate (PMA) significantly increased ERK1/2 phosphorylation and Na-K-ATPase activity.	Tetradecanoylphorbol Acetate	0-31	mitogen activated protein kinase 3	Rattus norvegicus	62-68
18223161-9	2008	Phorbol 12-myristate 13-acetate (PMA) significantly increased ERK1/2 phosphorylation and Na-K-ATPase activity.	Tetradecanoylphorbol Acetate	33-36	mitogen activated protein kinase 3	Rattus norvegicus	62-68
18178962-8	2008	We found that PKAc, which is maintained in an inactive form by binding to IkappaBalpha and NF-kappaB in resting cells, was activated by PMA-induced signaling and could phosphorylate p65.	Tetradecanoylphorbol Acetate	136-139	RELA proto-oncogene, NF-kB subunit	Homo sapiens	182-185
18061278-9	2008	All three anti-IL-10 mAbs detected a positive population in PMA stimulated lymphocytes which was absent in the medium controls.	Tetradecanoylphorbol Acetate	60-63	interleukin 10	Equus caballus	15-20
18061278-12	2008	Double staining with IL-4 or interferon-gamma (IFN-gamma) indicated that PMA and ionomycin stimulation induced 80% IL-10(+)/IFN-gamma(+) lymphocytes, while only 5% IL-10(+)/IL-4(+) cells were observed.	Tetradecanoylphorbol Acetate	73-76	interferon gamma	Equus caballus	29-45
18061278-12	2008	Double staining with IL-4 or interferon-gamma (IFN-gamma) indicated that PMA and ionomycin stimulation induced 80% IL-10(+)/IFN-gamma(+) lymphocytes, while only 5% IL-10(+)/IL-4(+) cells were observed.	Tetradecanoylphorbol Acetate	73-76	interferon gamma	Equus caballus	47-56
18061278-12	2008	Double staining with IL-4 or interferon-gamma (IFN-gamma) indicated that PMA and ionomycin stimulation induced 80% IL-10(+)/IFN-gamma(+) lymphocytes, while only 5% IL-10(+)/IL-4(+) cells were observed.	Tetradecanoylphorbol Acetate	73-76	interleukin 10	Equus caballus	115-120
18061278-12	2008	Double staining with IL-4 or interferon-gamma (IFN-gamma) indicated that PMA and ionomycin stimulation induced 80% IL-10(+)/IFN-gamma(+) lymphocytes, while only 5% IL-10(+)/IL-4(+) cells were observed.	Tetradecanoylphorbol Acetate	73-76	interferon gamma	Equus caballus	124-133
18061278-12	2008	Double staining with IL-4 or interferon-gamma (IFN-gamma) indicated that PMA and ionomycin stimulation induced 80% IL-10(+)/IFN-gamma(+) lymphocytes, while only 5% IL-10(+)/IL-4(+) cells were observed.	Tetradecanoylphorbol Acetate	73-76	interleukin 10	Equus caballus	164-169
18167130-4	2008	The phosphorylation of ERK(1/2) and p38 MAPK was regulated by upregulated protein kinase C beta (PKC beta) in HCC cells through the integrated use of PKC beta RNA interference, the PKC beta specific inhibitor enzastaurin and a PKC activator phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	241-272	protein kinase C beta	Homo sapiens	74-95
18167130-4	2008	The phosphorylation of ERK(1/2) and p38 MAPK was regulated by upregulated protein kinase C beta (PKC beta) in HCC cells through the integrated use of PKC beta RNA interference, the PKC beta specific inhibitor enzastaurin and a PKC activator phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	241-272	protein kinase C beta	Homo sapiens	97-105
18167130-4	2008	The phosphorylation of ERK(1/2) and p38 MAPK was regulated by upregulated protein kinase C beta (PKC beta) in HCC cells through the integrated use of PKC beta RNA interference, the PKC beta specific inhibitor enzastaurin and a PKC activator phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	241-272	protein kinase C beta	Homo sapiens	150-158
18167130-4	2008	The phosphorylation of ERK(1/2) and p38 MAPK was regulated by upregulated protein kinase C beta (PKC beta) in HCC cells through the integrated use of PKC beta RNA interference, the PKC beta specific inhibitor enzastaurin and a PKC activator phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	241-272	protein kinase C beta	Homo sapiens	150-158
18167130-4	2008	The phosphorylation of ERK(1/2) and p38 MAPK was regulated by upregulated protein kinase C beta (PKC beta) in HCC cells through the integrated use of PKC beta RNA interference, the PKC beta specific inhibitor enzastaurin and a PKC activator phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	241-272	protein kinase C beta	Homo sapiens	97-100
17965265-6	2008	PHME inhibited 60% of the fraction of 12-O-tetradecanoylphorbol-13-acetate-induced newly synthesized HDC in human HMC-1 cells at 200 microM and was also inhibitory in cell extracts.	Tetradecanoylphorbol Acetate	38-74	histidine decarboxylase	Homo sapiens	101-104
17924856-0	2008	PMA induces stabilization of oncostatin M mRNA in human lymphoma U937 cells.	Tetradecanoylphorbol Acetate	0-3	oncostatin M	Homo sapiens	29-41
18070609-4	2008	By contrast, phosphorylation of p65 at serine 276, which enhances the transcriptional activity of NF-kappaB, was up-regulated by TPA and was reduced by simultaneous exposure to LPS.	Tetradecanoylphorbol Acetate	129-132	RELA proto-oncogene, NF-kB subunit	Homo sapiens	32-35
18174253-6	2008	Moreover, treatment with 12(S)-hydroxyeicosatetraenoic acid (HETE), a metabolite of p12-LOX, enhanced TPA-induced neoplastic transformation either in the presence or absence of baicalein.	Tetradecanoylphorbol Acetate	102-105	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	84-91
17825416-4	2008	BAFF TVs were expressed in peripheral blood mononuclear cells (PBMC) of nearly all the individuals studied, decreasing in level when PBMC were activated by PMA and ionomycin.	Tetradecanoylphorbol Acetate	156-159	TNF superfamily member 13b	Homo sapiens	0-4
18024961-2	2008	An RasGRP4-defective variant of the human MC line HMC-1 was used to create stable clones expressing green fluorescent protein-labeled RasGRP4 for monitoring the movement of this protein inside MCs after exposure to phorbol 12-myristate 13-acetate (PMA), and for evaluating the protein"s ability to control gene expression.	Tetradecanoylphorbol Acetate	215-246	RAS guanyl releasing protein 4	Homo sapiens	134-141
18024961-2	2008	An RasGRP4-defective variant of the human MC line HMC-1 was used to create stable clones expressing green fluorescent protein-labeled RasGRP4 for monitoring the movement of this protein inside MCs after exposure to phorbol 12-myristate 13-acetate (PMA), and for evaluating the protein"s ability to control gene expression.	Tetradecanoylphorbol Acetate	248-251	RAS guanyl releasing protein 4	Homo sapiens	3-10
18024961-2	2008	An RasGRP4-defective variant of the human MC line HMC-1 was used to create stable clones expressing green fluorescent protein-labeled RasGRP4 for monitoring the movement of this protein inside MCs after exposure to phorbol 12-myristate 13-acetate (PMA), and for evaluating the protein"s ability to control gene expression.	Tetradecanoylphorbol Acetate	248-251	RAS guanyl releasing protein 4	Homo sapiens	134-141
17803461-2	2008	Here we found that PMA and H2O2 also induced the interaction of DGKgamma with beta2-chimaerin.	Tetradecanoylphorbol Acetate	19-22	diacylglycerol kinase gamma	Homo sapiens	64-72
17803461-2	2008	Here we found that PMA and H2O2 also induced the interaction of DGKgamma with beta2-chimaerin.	Tetradecanoylphorbol Acetate	19-22	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	78-83
18172297-5	2008	Here, we show that PLC epsilon(-/-) mice exhibit resistance to TPA-induced skin inflammation as assessed by reduction in edema, granulocyte infiltration, and expression of a proinflammatory cytokine, interleukin-1 alpha (IL-1 alpha).	Tetradecanoylphorbol Acetate	63-66	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	19-22
18172297-7	2008	In dermal fibroblast primary culture, TPA can induce activation of the PLC epsilon lipase activity, which leads to the induction of IL-1 alpha expression.	Tetradecanoylphorbol Acetate	38-41	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	71-74
18172297-8	2008	Experiments using small interfering RNA-mediated knockdown indicate that this activation is mediated by Rap1, which is activated by a TPA-responsive guanine nucleotide exchange factor RasGRP3.	Tetradecanoylphorbol Acetate	134-137	RAS-related protein 1a	Mus musculus	104-108
18172297-9	2008	Moreover, TPA-induced activation of Rap1 and PLC epsilon is inhibited by a PKC inhibitor GF109203X, indicating a crucial role of PKC in signaling from TPA to PLC epsilon.	Tetradecanoylphorbol Acetate	10-13	RAS-related protein 1a	Mus musculus	36-40
18172297-9	2008	Moreover, TPA-induced activation of Rap1 and PLC epsilon is inhibited by a PKC inhibitor GF109203X, indicating a crucial role of PKC in signaling from TPA to PLC epsilon.	Tetradecanoylphorbol Acetate	10-13	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	45-48
18172297-9	2008	Moreover, TPA-induced activation of Rap1 and PLC epsilon is inhibited by a PKC inhibitor GF109203X, indicating a crucial role of PKC in signaling from TPA to PLC epsilon.	Tetradecanoylphorbol Acetate	10-13	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	158-161
18172297-9	2008	Moreover, TPA-induced activation of Rap1 and PLC epsilon is inhibited by a PKC inhibitor GF109203X, indicating a crucial role of PKC in signaling from TPA to PLC epsilon.	Tetradecanoylphorbol Acetate	151-154	RAS-related protein 1a	Mus musculus	36-40
18172297-9	2008	Moreover, TPA-induced activation of Rap1 and PLC epsilon is inhibited by a PKC inhibitor GF109203X, indicating a crucial role of PKC in signaling from TPA to PLC epsilon.	Tetradecanoylphorbol Acetate	151-154	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	45-48
18172297-10	2008	These results imply that two TPA targets, RasGRP3 and PKC, are involved in TPA-induced inflammation through PLC epsilon activation, leading to tumor promotion.	Tetradecanoylphorbol Acetate	29-32	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	108-111
18172297-10	2008	These results imply that two TPA targets, RasGRP3 and PKC, are involved in TPA-induced inflammation through PLC epsilon activation, leading to tumor promotion.	Tetradecanoylphorbol Acetate	75-78	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	108-111
18692180-3	2008	Inhibition of PKC pathway, by chemical inhibitors or after PMA treatment, abolishes both IL-10 and TNF-alpha production.	Tetradecanoylphorbol Acetate	59-62	protein kinase C delta	Homo sapiens	14-17
18055557-4	2007	Phorbol-12-myristate-13-acetate (PMA)-induced mucin hypersecretion was significantly attenuated by rottlerin, a PKC delta-selective inhibitor.	Tetradecanoylphorbol Acetate	0-31	LOC100508689	Homo sapiens	46-51
18055557-4	2007	Phorbol-12-myristate-13-acetate (PMA)-induced mucin hypersecretion was significantly attenuated by rottlerin, a PKC delta-selective inhibitor.	Tetradecanoylphorbol Acetate	0-31	protein kinase C delta	Homo sapiens	112-121
18055557-4	2007	Phorbol-12-myristate-13-acetate (PMA)-induced mucin hypersecretion was significantly attenuated by rottlerin, a PKC delta-selective inhibitor.	Tetradecanoylphorbol Acetate	33-36	LOC100508689	Homo sapiens	46-51
18055557-4	2007	Phorbol-12-myristate-13-acetate (PMA)-induced mucin hypersecretion was significantly attenuated by rottlerin, a PKC delta-selective inhibitor.	Tetradecanoylphorbol Acetate	33-36	protein kinase C delta	Homo sapiens	112-121
17581112-4	2007	We found that the stimulation of cell motility induced by PKC (protein kinase C) activators, PMA and DPhT (diphenyltin), was inhibited significantly in the HEK-TrxR15 and HEK-TrxR11 cells compared with control cells.	Tetradecanoylphorbol Acetate	93-96	protein kinase C delta	Homo sapiens	58-61
17652337-0	2007	Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate represses sod2 induction in vivo: the negative role of p50.	Tetradecanoylphorbol Acetate	20-56	superoxide dismutase 2	Homo sapiens	67-71
17652337-1	2007	It is well documented that the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can activate manganese superoxide dismutase (MnSOD) expression.	Tetradecanoylphorbol Acetate	46-82	superoxide dismutase 2	Homo sapiens	102-132
17652337-1	2007	It is well documented that the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can activate manganese superoxide dismutase (MnSOD) expression.	Tetradecanoylphorbol Acetate	46-82	superoxide dismutase 2	Homo sapiens	134-139
17652337-1	2007	It is well documented that the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can activate manganese superoxide dismutase (MnSOD) expression.	Tetradecanoylphorbol Acetate	84-87	superoxide dismutase 2	Homo sapiens	102-132
17652337-1	2007	It is well documented that the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can activate manganese superoxide dismutase (MnSOD) expression.	Tetradecanoylphorbol Acetate	84-87	superoxide dismutase 2	Homo sapiens	134-139
17652337-3	2007	We generated transgenic mice expressing human MnSOD promoter- and enhancer-driven luciferase reporter gene and used a non-invasive imaging system to investigate the effects of TPA on MnSOD expression in vivo.	Tetradecanoylphorbol Acetate	176-179	superoxide dismutase 2	Homo sapiens	183-188
17652337-4	2007	Our data indicate that TPA initially activates MnSOD expression, but this positive effect declines after repeated applications.	Tetradecanoylphorbol Acetate	23-26	superoxide dismutase 2	Homo sapiens	47-52
17652337-6	2007	Using chromatin immunoprecipitation coupled to Western analysis of the transcription factors known to be essential for the constitutive and TPA-induced transcription of MnSOD, we found that TPA treatment leads to both activation and inactivation of MnSOD gene transcription.	Tetradecanoylphorbol Acetate	140-143	superoxide dismutase 2	Homo sapiens	169-174
17652337-6	2007	Using chromatin immunoprecipitation coupled to Western analysis of the transcription factors known to be essential for the constitutive and TPA-induced transcription of MnSOD, we found that TPA treatment leads to both activation and inactivation of MnSOD gene transcription.	Tetradecanoylphorbol Acetate	140-143	superoxide dismutase 2	Homo sapiens	249-254
17652337-6	2007	Using chromatin immunoprecipitation coupled to Western analysis of the transcription factors known to be essential for the constitutive and TPA-induced transcription of MnSOD, we found that TPA treatment leads to both activation and inactivation of MnSOD gene transcription.	Tetradecanoylphorbol Acetate	190-193	superoxide dismutase 2	Homo sapiens	169-174
19418353-6	2009	PMA induced the translocation of c-jun and p65 to the nucleus; however, IPE inhibited their nuclear translocations induced by PMA in HepG2 cells.	Tetradecanoylphorbol Acetate	0-3	RELA proto-oncogene, NF-kB subunit	Homo sapiens	43-46
17652337-6	2007	Using chromatin immunoprecipitation coupled to Western analysis of the transcription factors known to be essential for the constitutive and TPA-induced transcription of MnSOD, we found that TPA treatment leads to both activation and inactivation of MnSOD gene transcription.	Tetradecanoylphorbol Acetate	190-193	superoxide dismutase 2	Homo sapiens	249-254
17652337-7	2007	During the activation phase, the levels of p50, p65, specificity protein 1 (Sp1) and nucleophosmin (NPM) increase after TPA treatments.	Tetradecanoylphorbol Acetate	120-123	nucleophosmin 1	Homo sapiens	85-98
17652337-7	2007	During the activation phase, the levels of p50, p65, specificity protein 1 (Sp1) and nucleophosmin (NPM) increase after TPA treatments.	Tetradecanoylphorbol Acetate	120-123	nucleophosmin 1	Homo sapiens	100-103
17652337-8	2007	Sustained treatments with TPA lead to further increase of p50 but not p65, Sp1 or NPM, suggesting that excess p50 may have inhibitory effects leading to the suppression of MnSOD.	Tetradecanoylphorbol Acetate	26-29	superoxide dismutase 2	Homo sapiens	172-177
17652337-10	2007	These findings identify p50 as having a negative effect on MnSOD induction upon repeated applications of TPA and provide an insight into a cause for the reduction of MnSOD expression during early stages of skin carcinogenesis.	Tetradecanoylphorbol Acetate	105-108	superoxide dismutase 2	Homo sapiens	59-64
17976640-4	2007	All agonist treatments resulted in S2248 phosphorylation of mTOR and T389 and S421/T424 phosphorylation of S6K1, however only ET-1 and TPA-stimulated mTOR/S6K1 activation was abolished with infection of a dominant negative adenoviral c-Raf (DN-Raf) construct.	Tetradecanoylphorbol Acetate	135-138	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	234-239
19077250-12	2008	TPA induced phosphorylation of the PKC substrate myristoylated alanine-rich C kinase substrate (MARCKS) which was suppressed by the PKC inhibitors.	Tetradecanoylphorbol Acetate	0-3	myristoylated alanine rich protein kinase C substrate	Homo sapiens	96-102
19139002-6	2008	The activation of activator protein-1 and nuclear factor-kappaB induced by TPA was dose dependently inhibited by delphinidin treatment.	Tetradecanoylphorbol Acetate	75-78	jun proto-oncogene	Mus musculus	18-37
17976640-4	2007	All agonist treatments resulted in S2248 phosphorylation of mTOR and T389 and S421/T424 phosphorylation of S6K1, however only ET-1 and TPA-stimulated mTOR/S6K1 activation was abolished with infection of a dominant negative adenoviral c-Raf (DN-Raf) construct.	Tetradecanoylphorbol Acetate	135-138	zinc fingers and homeoboxes 2	Homo sapiens	236-239
19134409-5	2008	RESULTS: Compared with the control group, the expression of p-PKCalpha and ERK1/2, p-ERK1/2 protein increased, the expression of cyclinD1, P21(cip1) protein increased correspondingly (the A value % control was 2.10 +/- 0.29, 1.67 +/- 0.19, 2.20 +/- 0.27, 1.99 +/- 0.22 and 3.11 +/- 0.29 respectively; q value was 9.87, 7.06, 10.57, 11.10 and 20.33 respectively; all P &lt; 0.05) in PMA treated group, and cells proliferation [the percentage of cells in S phase was (30.3 +/- 2.4)%, A(490) value was 0.80 +/- 0.06] enhanced significantly compared with those [the percentage of cells in S phase was (13.9 +/- 2.6)%, A(490) value was 0.41 +/- 0.04] of the control group (q = 6.07, 12.63; all P &lt; 0.05).	Tetradecanoylphorbol Acetate	382-385	cyclin D1	Homo sapiens	129-137
17600309-1	2007	We previously showed that the MUC5B gene expression was elevated by phorbol 12-myristate 13-acetate (PMA) through an epidermal growth factor receptor-independent Ras/MEKK1/JNK and P38 signaling-based transcriptional mechanism.	Tetradecanoylphorbol Acetate	68-99	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	30-35
19134409-6	2008	In PMA and PKCalpha-asODN treated group, the level of p-PKCalpha decreased, the expression of ERK1/2, p-ERK1/2 and the expression of cyclinD1, P21(cip1) decreased correspondingly (the A value % control was 1.23 +/- 0.19, 1.34 +/- 0.18, 1.52 +/- 0.20, 1.45 +/- 0.18 and 1.49 +/- 0.18 respectively; q value was 7.49, 3.58, 5.97, 6.06 and 15.65 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (21.2 +/- 2.8)%, A(490) value was 0.51 +/- 0.04; q = 6.07, 12.63; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	gap junction protein alpha 1	Homo sapiens	54-64
19134409-6	2008	In PMA and PKCalpha-asODN treated group, the level of p-PKCalpha decreased, the expression of ERK1/2, p-ERK1/2 and the expression of cyclinD1, P21(cip1) decreased correspondingly (the A value % control was 1.23 +/- 0.19, 1.34 +/- 0.18, 1.52 +/- 0.20, 1.45 +/- 0.18 and 1.49 +/- 0.18 respectively; q value was 7.49, 3.58, 5.97, 6.06 and 15.65 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (21.2 +/- 2.8)%, A(490) value was 0.51 +/- 0.04; q = 6.07, 12.63; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	cyclin D1	Homo sapiens	133-141
17600309-1	2007	We previously showed that the MUC5B gene expression was elevated by phorbol 12-myristate 13-acetate (PMA) through an epidermal growth factor receptor-independent Ras/MEKK1/JNK and P38 signaling-based transcriptional mechanism.	Tetradecanoylphorbol Acetate	68-99	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	166-171
19134409-7	2008	In PMA and U0126 treated group, the level of p-PKCalpha had no significant change (A value was1.99 +/- 0.18, q = 0.94, P &gt; 0.05), but the levels of ERK1/2, p-ERK1/2 decreased, the expression of cyclinD1, P21(cip1) reduced (the A value % control was 0.95 +/- 0.21, 1.15 +/- 0.19, 1.37 +/- 0.15 and 1.96 +/- 0.21 respectively; q value was 7.79, 9.16, 6.92 and 11.16 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (22.0 +/- 3.2)%, A(490) value was 0.49 +/- 0.03; q = 5.51, 13.45; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	gap junction protein alpha 1	Homo sapiens	45-55
19134409-7	2008	In PMA and U0126 treated group, the level of p-PKCalpha had no significant change (A value was1.99 +/- 0.18, q = 0.94, P &gt; 0.05), but the levels of ERK1/2, p-ERK1/2 decreased, the expression of cyclinD1, P21(cip1) reduced (the A value % control was 0.95 +/- 0.21, 1.15 +/- 0.19, 1.37 +/- 0.15 and 1.96 +/- 0.21 respectively; q value was 7.79, 9.16, 6.92 and 11.16 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (22.0 +/- 3.2)%, A(490) value was 0.49 +/- 0.03; q = 5.51, 13.45; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	cyclin D1	Homo sapiens	197-205
17600309-1	2007	We previously showed that the MUC5B gene expression was elevated by phorbol 12-myristate 13-acetate (PMA) through an epidermal growth factor receptor-independent Ras/MEKK1/JNK and P38 signaling-based transcriptional mechanism.	Tetradecanoylphorbol Acetate	101-104	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	30-35
17600309-1	2007	We previously showed that the MUC5B gene expression was elevated by phorbol 12-myristate 13-acetate (PMA) through an epidermal growth factor receptor-independent Ras/MEKK1/JNK and P38 signaling-based transcriptional mechanism.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	166-171
17566060-8	2007	Ref-1 depletion also inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced anchorage-independent growth of JB6P+ by 40% and reduced the colony numbers of JB6P+/H2O2 and JB6P+/Cd cells.	Tetradecanoylphorbol Acetate	31-67	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	0-5
18768137-5	2008	MARCKS phosphorylation is switched on by treatment with PKC agonist PMA (Phorbol 12-Myristate 13-Acetate).	Tetradecanoylphorbol Acetate	68-71	myristoylated alanine rich protein kinase C substrate	Homo sapiens	0-6
18768137-5	2008	MARCKS phosphorylation is switched on by treatment with PKC agonist PMA (Phorbol 12-Myristate 13-Acetate).	Tetradecanoylphorbol Acetate	73-104	myristoylated alanine rich protein kinase C substrate	Homo sapiens	0-6
18541361-0	2008	Phorbol 12-myristate 13-acetate inhibits FRO anaplastic human thyroid cancer cell proliferation by inducing cell cycle arrest in G1/S phase: evidence for an effect mediated by PKCdelta.	Tetradecanoylphorbol Acetate	0-31	protein kinase C delta	Homo sapiens	176-184
17566060-8	2007	Ref-1 depletion also inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced anchorage-independent growth of JB6P+ by 40% and reduced the colony numbers of JB6P+/H2O2 and JB6P+/Cd cells.	Tetradecanoylphorbol Acetate	69-72	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	0-5
17407154-0	2007	The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells.	Tetradecanoylphorbol Acetate	127-130	transferrin receptor	Homo sapiens	4-24
18541361-9	2008	PKCdelta small interfering RNA attenuated the PMA-induced antiproliferative effect and prevented the upregulation of p21Waf1/Cip1 and p27Kip1.	Tetradecanoylphorbol Acetate	46-49	protein kinase C delta	Homo sapiens	0-8
17407154-4	2007	TPA increased targeting of CD81 and CD9P-1 into exosomes but strongly reduced the localization of the TfR in these vesicles.	Tetradecanoylphorbol Acetate	0-3	transferrin receptor	Homo sapiens	102-105
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	190-193	protein kinase C delta	Homo sapiens	37-46
17869664-8	2007	The estimated brachytherapy doses delivered to the APA as a percentage of the presumed 500-cGy fraction size to the TPA were 35.2% (176.6 +/- 59.0 cGy) on the right and 30.0% (150.2 +/- 42.9 cGy) on the left.	Tetradecanoylphorbol Acetate	116-119	glutamyl aminopeptidase	Homo sapiens	51-54
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	190-193	protein kinase C delta	Homo sapiens	37-40
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	190-193	protein kinase C delta	Homo sapiens	324-332
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	216-219	protein kinase C delta	Homo sapiens	37-46
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	216-219	protein kinase C delta	Homo sapiens	37-40
18404451-5	2007	Moreover, the PKC activator phorbol 12-myristate 13-acetate increased P2X(3) (but not P2X(2)) receptor-mediated currents.	Tetradecanoylphorbol Acetate	28-59	purinergic receptor P2X 3	Homo sapiens	70-76
18663158-5	2008	Here we report that caveolin-dependent internalization is involved in PKC-epsilon-mediated inhibition of vascular K(ATP) channels (Kir6.1 and SUR2B) by phorbol 12-myristate 13-acetate or angiotensin II in human embryonic kidney 293 cells and human dermal vascular smooth muscle cells.	Tetradecanoylphorbol Acetate	152-183	ATPase phospholipid transporting 8A2	Homo sapiens	116-119
17603012-6	2007	PMA enhanced the release of soluble IL-13Ralpha2, and metalloprotease inhibitors inhibited this release.	Tetradecanoylphorbol Acetate	0-3	interleukin 13 receptor subunit alpha 2	Homo sapiens	36-48
18690846-4	2008	The tumor promoter phorbol 12-myristate 13-acetate (PMA) enhanced the expression of 4Ig-hB7H3 in FEMX-I (melanoma), MA11 (breast cancer), and OHS (osteosarcoma) cells, suggesting that 4Ig-hB7H3 may be implicated in tumorigenesis.	Tetradecanoylphorbol Acetate	19-50	CD276 molecule	Homo sapiens	184-193
18690846-4	2008	The tumor promoter phorbol 12-myristate 13-acetate (PMA) enhanced the expression of 4Ig-hB7H3 in FEMX-I (melanoma), MA11 (breast cancer), and OHS (osteosarcoma) cells, suggesting that 4Ig-hB7H3 may be implicated in tumorigenesis.	Tetradecanoylphorbol Acetate	52-55	CD276 molecule	Homo sapiens	84-93
18690846-4	2008	The tumor promoter phorbol 12-myristate 13-acetate (PMA) enhanced the expression of 4Ig-hB7H3 in FEMX-I (melanoma), MA11 (breast cancer), and OHS (osteosarcoma) cells, suggesting that 4Ig-hB7H3 may be implicated in tumorigenesis.	Tetradecanoylphorbol Acetate	52-55	CD276 molecule	Homo sapiens	184-193
18425496-7	2008	We found that TPA promoted NF-kappaB nuclear translocation and the DNA binding of p65 dimers through PKC activation.	Tetradecanoylphorbol Acetate	14-17	RELA proto-oncogene, NF-kB subunit	Homo sapiens	82-85
17696950-4	2007	Following stimulation with PMA plus ionomycin, a reduced percentage of CD40L expression in T lymphocytes and a diminished expression of CD40 molecules in neutrophils were observed on leukocytes from these patients.	Tetradecanoylphorbol Acetate	27-30	CD40 molecule	Homo sapiens	71-75
18425496-11	2008	Subsequent experiments suggested that TPA contributed to this synergism by increasing the pool of free p65 which Tax could link to CBP and elevate, thereby, the amount of a p65-Tax-CBP ternary complex that could bind to NF-kappaB-responsive promoters and stimulate their expression.	Tetradecanoylphorbol Acetate	38-41	RELA proto-oncogene, NF-kB subunit	Homo sapiens	103-106
18425496-11	2008	Subsequent experiments suggested that TPA contributed to this synergism by increasing the pool of free p65 which Tax could link to CBP and elevate, thereby, the amount of a p65-Tax-CBP ternary complex that could bind to NF-kappaB-responsive promoters and stimulate their expression.	Tetradecanoylphorbol Acetate	38-41	RELA proto-oncogene, NF-kB subunit	Homo sapiens	173-176
17429438-4	2007	Epithelial carcinoma HeLa cells, which exclusively express Nox2, showed dramatically increased activation of NADPH oxidase by phorbol 12-myristate 13-acetate after S100A8/A9 gene transfection.	Tetradecanoylphorbol Acetate	126-157	S100 calcium binding protein A8	Homo sapiens	164-170
18384648-6	2008	12-O-tetradecanoylphorbol-13-actate (TPA), a direct activator of protein kinase C (PKC), stimulated the phosphorylation of HSP27 at Ser82, but not Ser15 in a time-dependent manner.	Tetradecanoylphorbol Acetate	37-40	heat shock protein family B (small) member 1	Rattus norvegicus	123-128
18384648-7	2008	Prostaglandin (PG) E(1) or PGE(2) which activates the adenylyl cyclase-cAMP system as well as forskolin and dibutyryl-cAMP, suppressed the TPA-induced phosphorylation of HSP27.	Tetradecanoylphorbol Acetate	139-142	heat shock protein family B (small) member 1	Rattus norvegicus	170-175
20219246-5	2010	We provide evidence that NUP98-PHF23, through its PHD domain, impairs TPA-induced differentiation of K562 cells.	Tetradecanoylphorbol Acetate	70-73	nucleoporin 98 and 96 precursor	Homo sapiens	25-30
20219246-5	2010	We provide evidence that NUP98-PHF23, through its PHD domain, impairs TPA-induced differentiation of K562 cells.	Tetradecanoylphorbol Acetate	70-73	PHD finger protein 23	Homo sapiens	31-36
17286201-8	2007	We demonstrate that PI 3-K signaling pathway suppresses PMA-induced expression of p21WAF1/Cip1 in human leukemia cells, and that this effect is partly mediated by PKC zeta.	Tetradecanoylphorbol Acetate	56-59	peptidase inhibitor 3	Homo sapiens	20-24
20479004-6	2010	Pin1(-/-) mouse embryonic fibroblasts showed lower 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MEK1/2 phosphorylation than Pin1(+/+) mouse embryonic fibroblasts.	Tetradecanoylphorbol Acetate	51-87	mitogen-activated protein kinase kinase 1	Mus musculus	102-108
20479004-6	2010	Pin1(-/-) mouse embryonic fibroblasts showed lower 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MEK1/2 phosphorylation than Pin1(+/+) mouse embryonic fibroblasts.	Tetradecanoylphorbol Acetate	89-92	mitogen-activated protein kinase kinase 1	Mus musculus	102-108
20479004-8	2010	Moreover, PD98059, a specific inhibitor of MEK1/2, and juglone, a potent Pin1 inhibitor, significantly suppressed the TPA-induced expression of E2F-4 as well as Egr-1 transcription factors, which control LC-3 gene expression.	Tetradecanoylphorbol Acetate	118-121	E2F transcription factor 4	Homo sapiens	144-149
17673262-3	2007	12-O-tetradecanoylphorbol-13-acetate (TPA) and 1-oleoyl-2-acetylglycerol, direct activators of protein kinase C (PKC), markedly strengthened the phosphorylation of HSP27.	Tetradecanoylphorbol Acetate	0-36	protein kinase C delta	Homo sapiens	113-116
20460381-10	2010	Preincubation of NCMs, with 10 nm extracellular concentrations of the mitochondrially targeted PKCdelta-dF(1)F(0) interaction inhibitor, decreased 100 nm 4beta-phorbol 12-myristate 13-acetate (4beta-PMA)-induced co-immunoprecipitation of PKCdelta with dF(1)F(0) by 50 +/- 15% and abolished the 30 nm 4beta-PMA-induced inhibition of F(1)F(0)-ATPase activity.	Tetradecanoylphorbol Acetate	154-191	protein kinase C delta	Homo sapiens	95-103
20460381-10	2010	Preincubation of NCMs, with 10 nm extracellular concentrations of the mitochondrially targeted PKCdelta-dF(1)F(0) interaction inhibitor, decreased 100 nm 4beta-phorbol 12-myristate 13-acetate (4beta-PMA)-induced co-immunoprecipitation of PKCdelta with dF(1)F(0) by 50 +/- 15% and abolished the 30 nm 4beta-PMA-induced inhibition of F(1)F(0)-ATPase activity.	Tetradecanoylphorbol Acetate	193-202	protein kinase C delta	Homo sapiens	95-103
20460381-10	2010	Preincubation of NCMs, with 10 nm extracellular concentrations of the mitochondrially targeted PKCdelta-dF(1)F(0) interaction inhibitor, decreased 100 nm 4beta-phorbol 12-myristate 13-acetate (4beta-PMA)-induced co-immunoprecipitation of PKCdelta with dF(1)F(0) by 50 +/- 15% and abolished the 30 nm 4beta-PMA-induced inhibition of F(1)F(0)-ATPase activity.	Tetradecanoylphorbol Acetate	300-309	protein kinase C delta	Homo sapiens	95-103
18419763-3	2008	In the present study, we found that expressions of MMP-1, -3, -8 and -9 were significantly induced by single or combined treatment of immunostimulants lipopolysaccharide (LPS) or phorbol myristate acetate (PMA) in primary cultured microglia and BV2 microglial cells.	Tetradecanoylphorbol Acetate	179-204	matrix metallopeptidase 13	Mus musculus	51-71
18419763-3	2008	In the present study, we found that expressions of MMP-1, -3, -8 and -9 were significantly induced by single or combined treatment of immunostimulants lipopolysaccharide (LPS) or phorbol myristate acetate (PMA) in primary cultured microglia and BV2 microglial cells.	Tetradecanoylphorbol Acetate	206-209	matrix metallopeptidase 13	Mus musculus	51-71
18400024-6	2008	Most PBP fractions decreased TPA-induced cell proliferation by decreasing activation of signalling kinases (c-Jun N-terminal protein kinase, extracellular signal-regulated protein kinase, p38 protein kinase and Akt), transcription factors (activator protein-1 and nuclear factor kappa B) and inflammatory protein (cyclooxygenase 2).	Tetradecanoylphorbol Acetate	29-32	mitogen-activated protein kinase 14	Mus musculus	188-191
17360811-7	2007	Treatment of mouse embryo fibroblast with PI3K inhibitors blocked PMA-directed colocalization between AFAP-110 and cSrc and subsequent cSrc activation.	Tetradecanoylphorbol Acetate	66-69	actin filament associated protein 1	Mus musculus	102-110
18400024-6	2008	Most PBP fractions decreased TPA-induced cell proliferation by decreasing activation of signalling kinases (c-Jun N-terminal protein kinase, extracellular signal-regulated protein kinase, p38 protein kinase and Akt), transcription factors (activator protein-1 and nuclear factor kappa B) and inflammatory protein (cyclooxygenase 2).	Tetradecanoylphorbol Acetate	29-32	jun proto-oncogene	Mus musculus	240-286
18400024-6	2008	Most PBP fractions decreased TPA-induced cell proliferation by decreasing activation of signalling kinases (c-Jun N-terminal protein kinase, extracellular signal-regulated protein kinase, p38 protein kinase and Akt), transcription factors (activator protein-1 and nuclear factor kappa B) and inflammatory protein (cyclooxygenase 2).	Tetradecanoylphorbol Acetate	29-32	prostaglandin-endoperoxide synthase 2	Mus musculus	314-330
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	126-157	protein kinase C beta	Homo sapiens	40-47
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	126-157	protein kinase C beta	Homo sapiens	62-69
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	126-157	interleukin 2 receptor subunit alpha	Homo sapiens	101-106
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	126-157	interleukin 2 receptor subunit alpha	Homo sapiens	107-111
17360811-11	2007	Thus PI3K activity is required for PMA-induced colocalization between AFAP-110 and cSrc and subsequent cSrc activation, and this signaling pathway promotes cell migration.	Tetradecanoylphorbol Acetate	35-38	actin filament associated protein 1	Mus musculus	70-78
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	126-157	protein kinase C beta	Homo sapiens	62-69
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	159-162	protein kinase C beta	Homo sapiens	40-47
17674818-7	2007	TPA enhanced lipid peroxidation with reduction in the level of catalase, glutathione, glutathione peroxidase, glutathione reductase and glutathione-s-transferase.	Tetradecanoylphorbol Acetate	0-3	glutathione reductase	Mus musculus	110-131
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	159-162	protein kinase C beta	Homo sapiens	62-69
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	159-162	interleukin 2 receptor subunit alpha	Homo sapiens	101-106
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	159-162	interleukin 2 receptor subunit alpha	Homo sapiens	107-111
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	159-162	protein kinase C beta	Homo sapiens	62-69
19943262-3	2010	Bergamottin reduced phorbol-12-myristate-13-acetate (PMA)-induced activation of MMP-9 and MMP-2 and further inhibited cell invasion and migration.	Tetradecanoylphorbol Acetate	20-51	matrix metallopeptidase 2	Homo sapiens	90-95
17210245-1	2007	We have previously reported that protein kinase C gamma (PKC-gamma) is activated by phorbol-12-myristate-13-acetate (TPA) and that this causes PKC-gamma translocation to membranes and phosphorylation of the gap junction protein, connexin 43 (Cx43).	Tetradecanoylphorbol Acetate	84-115	gap junction protein alpha 1	Homo sapiens	229-240
19943262-3	2010	Bergamottin reduced phorbol-12-myristate-13-acetate (PMA)-induced activation of MMP-9 and MMP-2 and further inhibited cell invasion and migration.	Tetradecanoylphorbol Acetate	53-56	matrix metallopeptidase 2	Homo sapiens	90-95
20469933-10	2010	MEK1/2, c-Jun, and STAT3 knockdown also reduced basal as well as PMA-induced Tspo mRNA levels in NIH-3T3 cells.	Tetradecanoylphorbol Acetate	65-68	mitogen-activated protein kinase kinase 1	Mus musculus	0-6
20469933-10	2010	MEK1/2, c-Jun, and STAT3 knockdown also reduced basal as well as PMA-induced Tspo mRNA levels in NIH-3T3 cells.	Tetradecanoylphorbol Acetate	65-68	jun proto-oncogene	Mus musculus	8-13
17210245-1	2007	We have previously reported that protein kinase C gamma (PKC-gamma) is activated by phorbol-12-myristate-13-acetate (TPA) and that this causes PKC-gamma translocation to membranes and phosphorylation of the gap junction protein, connexin 43 (Cx43).	Tetradecanoylphorbol Acetate	84-115	gap junction protein alpha 1	Homo sapiens	242-246
17210245-1	2007	We have previously reported that protein kinase C gamma (PKC-gamma) is activated by phorbol-12-myristate-13-acetate (TPA) and that this causes PKC-gamma translocation to membranes and phosphorylation of the gap junction protein, connexin 43 (Cx43).	Tetradecanoylphorbol Acetate	117-120	gap junction protein alpha 1	Homo sapiens	229-240
17210245-1	2007	We have previously reported that protein kinase C gamma (PKC-gamma) is activated by phorbol-12-myristate-13-acetate (TPA) and that this causes PKC-gamma translocation to membranes and phosphorylation of the gap junction protein, connexin 43 (Cx43).	Tetradecanoylphorbol Acetate	117-120	gap junction protein alpha 1	Homo sapiens	242-246
20351306-6	2010	Microvascular endothelial cells from lung, heart, intestine, and skin as well as endothelial cells from pulmonary artery constitutively secreted FVIII and released it after treatment with phorbol-myristate acetate and epinephrine.	Tetradecanoylphorbol Acetate	188-213	coagulation factor VIII	Homo sapiens	145-150
17394101-4	2007	Deerberry fruit extracts also blocked TPA- or UVB-induced phosphorylation of ERKs and MEK 1/2, two upstream regulators of AP-1 and inhibited proliferation of human leukemia HL-60 cancer cells and human lung epithelial cancer A549 cells and induced apoptosis of HL-60 cells.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase kinase 2	Homo sapiens	86-93
20172950-3	2010	Surprisingly, TGFbeta1+/- mice had fewer number and incidence of benign papillomas, reduced epidermal and tumor cell proliferation and reduced epidermal TGFbeta1 and nuclear p-Smad2 localization in response to the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) compared with TGFbeta1+/+ mice.	Tetradecanoylphorbol Acetate	267-270	transforming growth factor, beta 1	Mus musculus	14-22
20172950-4	2010	Maximal TPA activation of protein kinase C (PKCalpha) as measured by activity assays and activation of target genes and induction of cornified envelopes correlated with TGFbeta1 gene dosage in keratinocytes and addition of exogenous TGFbeta1 restored the cornification defect in TGFbeta1+/- keratinocytes.	Tetradecanoylphorbol Acetate	8-11	transforming growth factor, beta 1	Mus musculus	169-177
20172950-4	2010	Maximal TPA activation of protein kinase C (PKCalpha) as measured by activity assays and activation of target genes and induction of cornified envelopes correlated with TGFbeta1 gene dosage in keratinocytes and addition of exogenous TGFbeta1 restored the cornification defect in TGFbeta1+/- keratinocytes.	Tetradecanoylphorbol Acetate	8-11	transforming growth factor, beta 1	Mus musculus	233-241
20172950-4	2010	Maximal TPA activation of protein kinase C (PKCalpha) as measured by activity assays and activation of target genes and induction of cornified envelopes correlated with TGFbeta1 gene dosage in keratinocytes and addition of exogenous TGFbeta1 restored the cornification defect in TGFbeta1+/- keratinocytes.	Tetradecanoylphorbol Acetate	8-11	transforming growth factor, beta 1	Mus musculus	233-241
20172950-5	2010	Similarly, inhibition of ALK5-suppressed TPA-mediated PKCalpha activation suggesting that physiological levels of TGFbeta1 are required for maximal activation of PKC-dependent mitogenic responses.	Tetradecanoylphorbol Acetate	41-44	transforming growth factor, beta 1	Mus musculus	114-122
17299772-4	2007	Tissue type plasminogen activator (tPA) is a well-known extracellular serine protease and is involved in the modification of the extracellular matrix, which leads to neuroplastic changes such as long-term potentiation in the hippocampus.	Tetradecanoylphorbol Acetate	35-38	kallikrein 1-related peptidase C8	Rattus norvegicus	70-85
20172950-6	2010	Paradoxically, the TPA-induced inflammatory response was greater in TGFbeta1+/- skin, but TGFbeta1+/+ papillomas had more tumor infiltrating myeloperoxidase-positive cells and pro-inflammatory gene expression was elevated in v-ras(Ha)-transduced TGFbeta1+/+ but not TGFbeta1+/- keratinocytes.	Tetradecanoylphorbol Acetate	19-22	transforming growth factor, beta 1	Mus musculus	68-76
20172950-8	2010	Despite this differential proliferative and inflammatory response to TPA and enhanced papilloma formation in the TGFbeta1+/+ mice, the frequency of malignant conversion was reduced compared with TGFbeta1+/- mice.	Tetradecanoylphorbol Acetate	69-72	transforming growth factor, beta 1	Mus musculus	113-121
17303575-2	2007	Previous studies showed that treatment of MCF-7 mammary carcinoma cells with the potent protein kinase C (PKC) agonist, phorbol 12-myristate 13-acetate (PMA), induces a transient drop in sphingomyelin concomitant with an increase in cellular ceramide levels (Becker, K. P., Kitatani, K., Idkowiak-Baldys, J., Bielawski, J., and Hannun, Y.	Tetradecanoylphorbol Acetate	120-151	protein kinase C delta	Homo sapiens	106-109
20406988-5	2010	Interestingly, the association of Cx43 with Cav-1 was found to be reduced after TPA and EGF treatment.	Tetradecanoylphorbol Acetate	80-83	gap junction protein alpha 1	Homo sapiens	34-38
20444294-7	2010	Two miRNAs, miR-101, and miR-29c, were shown to be significantly down regulated in human hepatoma tissues and induced over 4-fold in HepG2 cells under TPA treatment.	Tetradecanoylphorbol Acetate	151-154	microRNA 29c	Homo sapiens	25-32
20444294-10	2010	Since induction kinetics of miR-101 by TPA was much faster than miR-29c suggests that the induction of miR-101 may be the primary response of TPA treatment.	Tetradecanoylphorbol Acetate	142-145	microRNA 29c	Homo sapiens	64-71
20426528-10	2010	The activation of PKC alpha with phorbol myristate acetate (PMA), a PKC activator, up-regulated cyclin D1 expression and increased the proliferation of passively sensitized HASMCs.	Tetradecanoylphorbol Acetate	33-58	cyclin D1	Homo sapiens	96-105
20426528-10	2010	The activation of PKC alpha with phorbol myristate acetate (PMA), a PKC activator, up-regulated cyclin D1 expression and increased the proliferation of passively sensitized HASMCs.	Tetradecanoylphorbol Acetate	60-63	cyclin D1	Homo sapiens	96-105
20426528-12	2010	In addition, the authors showed that transfection with antisense cyclin D1 abolished PMA-induced G1/S progression and HASMC proliferation.	Tetradecanoylphorbol Acetate	85-88	cyclin D1	Homo sapiens	65-74
17303575-2	2007	Previous studies showed that treatment of MCF-7 mammary carcinoma cells with the potent protein kinase C (PKC) agonist, phorbol 12-myristate 13-acetate (PMA), induces a transient drop in sphingomyelin concomitant with an increase in cellular ceramide levels (Becker, K. P., Kitatani, K., Idkowiak-Baldys, J., Bielawski, J., and Hannun, Y.	Tetradecanoylphorbol Acetate	153-156	protein kinase C delta	Homo sapiens	106-109
17151144-7	2007	Indeed, the PKC-delta-selective inhibitor rottlerin significantly blocked PMA-induced inhibition of Slc26a6 activity.	Tetradecanoylphorbol Acetate	74-77	solute carrier family 26, member 6	Mus musculus	100-107
20213728-0	2010	CARM1 activates myogenin gene via PCAF in the early differentiation of TPA-induced rhabdomyosarcoma-derived cells.	Tetradecanoylphorbol Acetate	71-74	myogenin	Homo sapiens	16-24
20213728-0	2010	CARM1 activates myogenin gene via PCAF in the early differentiation of TPA-induced rhabdomyosarcoma-derived cells.	Tetradecanoylphorbol Acetate	71-74	lysine acetyltransferase 2B	Homo sapiens	34-38
20213728-3	2010	Here, we show that CARM1 can be recruited to the promoter of myogenin gene to enhance its transcriptional activation via PCAF at the early stage of TPA-induced RD cell differentiation.	Tetradecanoylphorbol Acetate	148-151	myogenin	Homo sapiens	61-69
20213728-3	2010	Here, we show that CARM1 can be recruited to the promoter of myogenin gene to enhance its transcriptional activation via PCAF at the early stage of TPA-induced RD cell differentiation.	Tetradecanoylphorbol Acetate	148-151	lysine acetyltransferase 2B	Homo sapiens	121-125
20213728-4	2010	By adding adenosine dialdehyde, AdOx, to inhibit the PRMT in RD cells, the TPA-induced recruiting of p300, PCAF and the Brg1 at the myogenin promoter is abolished and myogenic differentiation is blocked.	Tetradecanoylphorbol Acetate	75-78	E1A binding protein p300	Homo sapiens	101-105
20213728-4	2010	By adding adenosine dialdehyde, AdOx, to inhibit the PRMT in RD cells, the TPA-induced recruiting of p300, PCAF and the Brg1 at the myogenin promoter is abolished and myogenic differentiation is blocked.	Tetradecanoylphorbol Acetate	75-78	lysine acetyltransferase 2B	Homo sapiens	107-111
20213728-4	2010	By adding adenosine dialdehyde, AdOx, to inhibit the PRMT in RD cells, the TPA-induced recruiting of p300, PCAF and the Brg1 at the myogenin promoter is abolished and myogenic differentiation is blocked.	Tetradecanoylphorbol Acetate	75-78	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	120-124
20213728-4	2010	By adding adenosine dialdehyde, AdOx, to inhibit the PRMT in RD cells, the TPA-induced recruiting of p300, PCAF and the Brg1 at the myogenin promoter is abolished and myogenic differentiation is blocked.	Tetradecanoylphorbol Acetate	75-78	myogenin	Homo sapiens	132-140
20213728-6	2010	We suggest that the physical interaction of CARM1 and PCAF is likely pivotal for the activation of PCAF in the downstream of CARM1 pathway for inducing myogenin under TPA-induced differentiation.	Tetradecanoylphorbol Acetate	167-170	lysine acetyltransferase 2B	Homo sapiens	54-58
20213728-6	2010	We suggest that the physical interaction of CARM1 and PCAF is likely pivotal for the activation of PCAF in the downstream of CARM1 pathway for inducing myogenin under TPA-induced differentiation.	Tetradecanoylphorbol Acetate	167-170	lysine acetyltransferase 2B	Homo sapiens	99-103
20213728-6	2010	We suggest that the physical interaction of CARM1 and PCAF is likely pivotal for the activation of PCAF in the downstream of CARM1 pathway for inducing myogenin under TPA-induced differentiation.	Tetradecanoylphorbol Acetate	167-170	myogenin	Homo sapiens	152-160
20056911-5	2010	Phorbol-12-myristate-13 acetate (PMA) upregulates MMP-14 mRNA via protein kinase C-extracellular signal-regulated kinase pathways, and enhanced soluble Tie-2 production in an MMP-14-dependent manner, resulting in a reduction of cellular fTie-2.	Tetradecanoylphorbol Acetate	0-31	matrix metallopeptidase 14	Homo sapiens	50-56
17430640-2	2007	In this study, we show that ergolide suppresses the DNA binding activity of NF-kappaB and nuclear translocation of NF-kappaB p65 subunit, leading to the inhibition of NF-kappaB-dependent gene transcription in 12-O-tetradecanoylphorbol 13acetate (TPA)-stimulated HeLa cells.	Tetradecanoylphorbol Acetate	209-244	RELA proto-oncogene, NF-kB subunit	Homo sapiens	115-128
20163138-1	2010	NADPH oxidase 4 (Nox4) is constitutively active, while Nox2 requires the cytosolic regulatory subunits p47(phox) and p67(phox) and activated Rac with activation by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	164-195	NADPH oxidase 4	Homo sapiens	0-15
20163138-6	2010	In contrast, chimera Nox4/2, consisting of the Nox4 TM and Nox2 DH domains, exhibited PMA-dependent activation that required coexpression of regulatory subunits.	Tetradecanoylphorbol Acetate	86-89	NADPH oxidase 4	Homo sapiens	21-25
17430640-2	2007	In this study, we show that ergolide suppresses the DNA binding activity of NF-kappaB and nuclear translocation of NF-kappaB p65 subunit, leading to the inhibition of NF-kappaB-dependent gene transcription in 12-O-tetradecanoylphorbol 13acetate (TPA)-stimulated HeLa cells.	Tetradecanoylphorbol Acetate	246-249	RELA proto-oncogene, NF-kB subunit	Homo sapiens	115-128
17493330-5	2007	The aim of this study was to investigate the expression of MtF, transferrin receptor 1 (TfR1) and ferritin (Fn) mRNAs in K562 leukemic cells during TPA-induced cell differentiation and to explore the interrelationship between the expression levels of these iron metabolism-related molecules.	Tetradecanoylphorbol Acetate	148-151	transferrin receptor	Homo sapiens	64-86
20047593-6	2010	Using a confocal microscopic analysis of CCA cell lines that had been stimulated with the PKC activator, 12-0-tetradecanoyl phorbol-13-acetate (TPA), MARCKS was found to be translocated from the plasma membrane to the perinuclear area.	Tetradecanoylphorbol Acetate	144-147	myristoylated alanine rich protein kinase C substrate	Homo sapiens	150-156
20047593-9	2010	Interestingly, after TPA stimulation, the CCA cell line-depleted MARCKS showed a decrease in migration and invasion activity.	Tetradecanoylphorbol Acetate	21-24	myristoylated alanine rich protein kinase C substrate	Homo sapiens	65-71
20047593-11	2010	After TPA stimulation, PKC phosphorylates MARCKS leading to cell migration or invasion.	Tetradecanoylphorbol Acetate	6-9	myristoylated alanine rich protein kinase C substrate	Homo sapiens	42-48
17493330-5	2007	The aim of this study was to investigate the expression of MtF, transferrin receptor 1 (TfR1) and ferritin (Fn) mRNAs in K562 leukemic cells during TPA-induced cell differentiation and to explore the interrelationship between the expression levels of these iron metabolism-related molecules.	Tetradecanoylphorbol Acetate	148-151	transferrin receptor	Homo sapiens	88-92
20080871-3	2010	Immunohistochemistry and Western blot experiments in 4B cells revealed time-dependent nuclear translocation of TORC1,TORC 2, and TORC3 by forskolin [but not by the phorbol ester, phorbol 12-myristate 13-acetate (PMA)] in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	212-215	CREB regulated transcription coactivator 1	Homo sapiens	111-116
17493330-12	2007	After 5 days of induced cell differentiation, expression levels of MtF and TfR1 mRNA were just 50.3% and 68.2% of that before TPA treatment.	Tetradecanoylphorbol Acetate	126-129	transferrin receptor	Homo sapiens	75-79
20080871-3	2010	Immunohistochemistry and Western blot experiments in 4B cells revealed time-dependent nuclear translocation of TORC1,TORC 2, and TORC3 by forskolin [but not by the phorbol ester, phorbol 12-myristate 13-acetate (PMA)] in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	212-215	CREB regulated transcription coactivator 3	Homo sapiens	129-134
19952305-1	2010	Chemical coupling to carrier red blood cells (RBCs) converts tissue type plasminogen activator (tPA) from a problematic therapeutic into a safe agent for thromboprophylaxis.	Tetradecanoylphorbol Acetate	96-99	plasminogen activator, tissue	Mus musculus	61-94
17227770-7	2007	At variance, the proteasome inhibitor lactacystin mimicked TPA action on PED/PEA-15 intracellular accumulation and reverted the effects of PKC-zeta and CaMK inhibition.	Tetradecanoylphorbol Acetate	59-62	OCA2 melanosomal transmembrane protein	Homo sapiens	73-76
20053986-2	2010	To bind to its target AP-1/12-O-tetradecanoylphorbol-13-acetate-responsive element or cAMP-responsive element DNA sequences in gene promoters and exert its transcriptional part, c-Fos must heterodimerize with other bZip proteins, its best studied partners being the Jun proteins (c-Jun, JunB, and JunD).	Tetradecanoylphorbol Acetate	27-63	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	297-301
17227770-9	2007	PED/PEA-15 ubiquitinylation was reduced by TPA and PKC-zeta overexpression and increased by KN-93 and PKC-zeta block.	Tetradecanoylphorbol Acetate	43-46	OCA2 melanosomal transmembrane protein	Homo sapiens	0-3
17227770-10	2007	Furthermore, in HEK293 cells expressing PED(S116G), TPA failed to prevent ubiquitin-dependent degradation of the protein.	Tetradecanoylphorbol Acetate	52-55	OCA2 melanosomal transmembrane protein	Homo sapiens	40-43
20037153-7	2010	Stimulation by phorbol myristate acetate enhanced WT channel gating, and this effect was reversed by treatment with the PKC inhibitor GF109203X.	Tetradecanoylphorbol Acetate	15-40	protein kinase C delta	Homo sapiens	120-123
17227770-12	2007	Taken together, our results indicate that TPA increases PED/PEA-15 expression at the post-translational level by inducing phosphorylation at serine 116 and preventing ubiquitinylation and proteosomal degradation.	Tetradecanoylphorbol Acetate	42-45	OCA2 melanosomal transmembrane protein	Homo sapiens	56-59
17258194-4	2007	Western blot analysis revealed that alpha-amyrin dose-dependently inhibited TPA-induced COX-2 expression in the mouse skin.	Tetradecanoylphorbol Acetate	76-79	cytochrome c oxidase II, mitochondrial	Mus musculus	88-93
19917606-9	2010	Finally, rat adrenal medullary endothelial cells transfected with (S730A)VACM-1/cul5 cDNA and treated with phorbol 12-myristate 13-acetate (10 and 100 nm) to induce PKC activity grew significantly faster than the control cells.	Tetradecanoylphorbol Acetate	107-138	cullin 5	Rattus norvegicus	73-79
17210122-0	2007	Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation.	Tetradecanoylphorbol Acetate	31-34	protein kinase C delta	Homo sapiens	90-98
19917606-9	2010	Finally, rat adrenal medullary endothelial cells transfected with (S730A)VACM-1/cul5 cDNA and treated with phorbol 12-myristate 13-acetate (10 and 100 nm) to induce PKC activity grew significantly faster than the control cells.	Tetradecanoylphorbol Acetate	107-138	cullin 5	Rattus norvegicus	80-84
17332533-8	2007	In intact AR4-2J cells metabolically labelled with (32)Pi, we showed that phorbol-12-myristate-13-acetate (PMA) and Ca(2+) mobilizing agonists cause the phosphorylation of IP(3)R-2.	Tetradecanoylphorbol Acetate	74-105	inositol 1,4,5-trisphosphate receptor, type 2	Rattus norvegicus	172-180
20407607-2	2010	We hypothesized that minocycline induced MMP-2 and MMP-9 inhibition can be enhanced by aspirin, a non-selective COX and tPA inhibitor and this combination can reduce progression of diabetic retinopathy.	Tetradecanoylphorbol Acetate	120-123	matrix metallopeptidase 2	Rattus norvegicus	41-46
19922761-5	2010	PVAE inhibited PMA-induced NF-kappaB nuclear translocation, which is upstream of PMA-induced MMP-9 expression and invasion.	Tetradecanoylphorbol Acetate	15-18	matrix metallopeptidase 9	Mus musculus	93-98
19922761-7	2010	PVAE repressed the PMA-induced phosphorylation of ERK1/2, which is upstream signaling molecules in MMP-9 expression.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase 3	Mus musculus	50-56
19922761-7	2010	PVAE repressed the PMA-induced phosphorylation of ERK1/2, which is upstream signaling molecules in MMP-9 expression.	Tetradecanoylphorbol Acetate	19-22	matrix metallopeptidase 9	Mus musculus	99-104
17332533-8	2007	In intact AR4-2J cells metabolically labelled with (32)Pi, we showed that phorbol-12-myristate-13-acetate (PMA) and Ca(2+) mobilizing agonists cause the phosphorylation of IP(3)R-2.	Tetradecanoylphorbol Acetate	107-110	inositol 1,4,5-trisphosphate receptor, type 2	Rattus norvegicus	172-180
18445064-7	2008	While both PMA-treated or untreated THP-1 cells could uptake hCG into their cytoplasms, hCG degradation and excretion of its byproducts only progressed in PMA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	11-14	chorionic gonadotropin subunit beta 5	Homo sapiens	61-64
17052756-6	2007	Furthermore, a CaMKII inhibitor, KN93, and CaMKII siRNA substantially reduce Bcl10 phosphorylation induced by phorbol myristate acetate/ionomycin.	Tetradecanoylphorbol Acetate	110-135	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	15-21
18445064-7	2008	While both PMA-treated or untreated THP-1 cells could uptake hCG into their cytoplasms, hCG degradation and excretion of its byproducts only progressed in PMA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	155-158	chorionic gonadotropin subunit beta 5	Homo sapiens	61-64
18445064-7	2008	While both PMA-treated or untreated THP-1 cells could uptake hCG into their cytoplasms, hCG degradation and excretion of its byproducts only progressed in PMA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	155-158	chorionic gonadotropin subunit beta 5	Homo sapiens	88-91
17052756-6	2007	Furthermore, a CaMKII inhibitor, KN93, and CaMKII siRNA substantially reduce Bcl10 phosphorylation induced by phorbol myristate acetate/ionomycin.	Tetradecanoylphorbol Acetate	110-135	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	43-49
17052756-6	2007	Furthermore, a CaMKII inhibitor, KN93, and CaMKII siRNA substantially reduce Bcl10 phosphorylation induced by phorbol myristate acetate/ionomycin.	Tetradecanoylphorbol Acetate	110-135	BCL10 immune signaling adaptor	Homo sapiens	77-82
18483242-5	2008	The studies presented herein show that, in MCF-7 breast and ECC-1 endocervical cancer cells, the stimulation of aryl hydrocarbon receptor (AHR) activity, in combination with IL-1beta or phorbol 12-myristate 13-acetate (PMA) treatment, results in a marked synergistic induction of IL-6 levels over what is seen without AHR activation.	Tetradecanoylphorbol Acetate	219-222	aryl hydrocarbon receptor	Homo sapiens	112-137
18483242-5	2008	The studies presented herein show that, in MCF-7 breast and ECC-1 endocervical cancer cells, the stimulation of aryl hydrocarbon receptor (AHR) activity, in combination with IL-1beta or phorbol 12-myristate 13-acetate (PMA) treatment, results in a marked synergistic induction of IL-6 levels over what is seen without AHR activation.	Tetradecanoylphorbol Acetate	219-222	aryl hydrocarbon receptor	Homo sapiens	139-142
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	95-98	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	142-160
18483250-6	2008	Western blot analyses of epidermal extracts revealed reduced activation of both the epidermal growth factor and IGF-I receptors in response to TPA treatment in LID mice.	Tetradecanoylphorbol Acetate	143-146	insulin-like growth factor 1	Mus musculus	112-117
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	95-98	keratin 16	Homo sapiens	162-172
18407667-9	2008	Interestingly, vimentin, the IF characteristic of leukocytes, is one of the major proteins recognized by SP-A in protein extracts of U937 cells after PMA-induced differentiation of this monocytic cell line.	Tetradecanoylphorbol Acetate	150-153	surfactant protein A1	Homo sapiens	105-109
19995913-7	2010	Substitution of the carboxyl terminus was sufficient for converting Nox4 into a phorbol myristate acetate (PMA)-inducible phenotype, while Nox2-based chimeras never gained constitutive activity.	Tetradecanoylphorbol Acetate	80-105	NADPH oxidase 4	Homo sapiens	68-72
19995913-7	2010	Substitution of the carboxyl terminus was sufficient for converting Nox4 into a phorbol myristate acetate (PMA)-inducible phenotype, while Nox2-based chimeras never gained constitutive activity.	Tetradecanoylphorbol Acetate	107-110	NADPH oxidase 4	Homo sapiens	68-72
17088249-5	2007	Similar to the other ABINs, ABIN-3 binds to A20 and inhibits NF-kappaB activation induced by tumor necrosis factor, interleukin-1, and 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	135-171	TNFAIP3 interacting protein 3	Homo sapiens	28-34
20004474-13	2010	Chemical inhibition of TGase II by cystamine exerted negative effect on Balb/c mouse model of phorbol myristate acetate (PMA)-induced atopic dermatitis.	Tetradecanoylphorbol Acetate	94-119	transglutaminase 2	Rattus norvegicus	23-31
20004474-13	2010	Chemical inhibition of TGase II by cystamine exerted negative effect on Balb/c mouse model of phorbol myristate acetate (PMA)-induced atopic dermatitis.	Tetradecanoylphorbol Acetate	121-124	transglutaminase 2	Rattus norvegicus	23-31
17200207-5	2007	In a transmembrane invasion assay, phorbol-12-myristate-13-acetate (100 nmol/L) increased the number of invaded HP75 cells, a process that was attenuated by PKC inhibitors, MMP-9 antibody, PKC-alpha siRNA, or PKC-delta siRNA.	Tetradecanoylphorbol Acetate	35-66	protein kinase C delta	Homo sapiens	209-218
17202682-5	2007	In addition, asiatic acid inhibited the TPA-induced generation of nitric oxide (NO) and expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), which are known to play important roles in tumor growth, especially in the promotion stage.	Tetradecanoylphorbol Acetate	40-43	prostaglandin-endoperoxide synthase 2	Mus musculus	135-151
20026373-0	2010	Naturally occurring phenolic acids inhibit 12-O-tetradecanoylphorbol-13-acetate induced NF-kappaB, iNOS and COX-2 activation in mouse epidermis.	Tetradecanoylphorbol Acetate	43-79	cytochrome c oxidase II, mitochondrial	Mus musculus	108-113
18466703-4	2008	Equine IFN-gamma was detected by ELISA in culture medium of the peripheral blood mononuclear cells (PBMCs) stimulated with ConA or PMA/Ionomycin.	Tetradecanoylphorbol Acetate	131-134	interferon gamma	Equus caballus	7-16
17202682-5	2007	In addition, asiatic acid inhibited the TPA-induced generation of nitric oxide (NO) and expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), which are known to play important roles in tumor growth, especially in the promotion stage.	Tetradecanoylphorbol Acetate	40-43	prostaglandin-endoperoxide synthase 2	Mus musculus	153-158
20026244-8	2010	Treatment of alpha-synuclein increased the phosphorylation of ERK1/2 and the inhibition of ERK1/2 reversed the changes in MMP-9 and tPA activity.	Tetradecanoylphorbol Acetate	132-135	mitogen activated protein kinase 3	Rattus norvegicus	91-97
17438848-6	2007	The percentage of cells of active AP-1, IL-5 protein in supernatants of allergic rhinitis T lymphocytes stimulated with PMA and curcumin were significantly lower than those of allergic rhinitis T lymphocytes stimulated with PMA (P &lt; 0.01); but significantly higher than those of allergic rhinitis T lymphocytes stimulated without PMA and those of deflection of nasal septum T lymphocytes stimulated.	Tetradecanoylphorbol Acetate	120-123	interleukin 5	Homo sapiens	40-44
20043876-6	2010	Using mass spectrometry, we report now that TRPV4 is phosphorylated on serine 824 by the PKC-activating phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	104-135	transient receptor potential cation channel subfamily V member 4	Homo sapiens	44-49
18160398-3	2008	Thus, conditional expression of PAK1 dominant-positive mutants enhanced, whereas dominant-negative mutants inhibited, NADPH oxidase-mediated superoxide generation following formyl-methionyl-leucylphenylalanine or phorbol 12-myristate 13-acetate stimulation.	Tetradecanoylphorbol Acetate	213-244	p21 (RAC1) activated kinase 1	Homo sapiens	32-36
18354023-7	2008	Consistent with this, phorbol 12-myristate 13-acetate, a PKC activator, mimicked the HCRT-induced potentiation.	Tetradecanoylphorbol Acetate	22-53	hypocretin neuropeptide precursor	Homo sapiens	85-89
16823786-5	2006	Phorbol 12-myristate 13-acetate (PMA) (100 ng/ml) was used to stimulate PKC, and genistein (10 microM) and lavendustin A (1 microM) as unspecific TyrK inhibitors.	Tetradecanoylphorbol Acetate	0-31	protein kinase C delta	Homo sapiens	72-75
18164693-5	2008	Topical application on mice ears of Tat-SOD also suppressed TPA-induced expression of proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 as well as cyclooxygenase-2 (COX-2) and production of PGE(2).	Tetradecanoylphorbol Acetate	60-63	prostaglandin-endoperoxide synthase 2	Mus musculus	161-177
18164693-5	2008	Topical application on mice ears of Tat-SOD also suppressed TPA-induced expression of proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 as well as cyclooxygenase-2 (COX-2) and production of PGE(2).	Tetradecanoylphorbol Acetate	60-63	prostaglandin-endoperoxide synthase 2	Mus musculus	179-184
19914607-4	2010	The results show that phorbol 12-myristate 13-acetate (PMA) treatment (with or without ionomycin) and serum starvation (s/s) induced sustained ERK1/2 activation in murine thymocytes.	Tetradecanoylphorbol Acetate	22-53	mitogen-activated protein kinase 3	Mus musculus	143-149
19914607-4	2010	The results show that phorbol 12-myristate 13-acetate (PMA) treatment (with or without ionomycin) and serum starvation (s/s) induced sustained ERK1/2 activation in murine thymocytes.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 3	Mus musculus	143-149
19914607-5	2010	Importantly, pharmacological treatment of thymocytes with the MEK inhibitor UO126 revealed that PMA-induced ERK1/2 activation was proapoptotic, whereas serum starvation-induced ERK1/2 activation inhibited apoptosis and promoted cell survival.	Tetradecanoylphorbol Acetate	96-99	midkine	Mus musculus	62-65
19914607-5	2010	Importantly, pharmacological treatment of thymocytes with the MEK inhibitor UO126 revealed that PMA-induced ERK1/2 activation was proapoptotic, whereas serum starvation-induced ERK1/2 activation inhibited apoptosis and promoted cell survival.	Tetradecanoylphorbol Acetate	96-99	mitogen-activated protein kinase 3	Mus musculus	108-114
16823786-5	2006	Phorbol 12-myristate 13-acetate (PMA) (100 ng/ml) was used to stimulate PKC, and genistein (10 microM) and lavendustin A (1 microM) as unspecific TyrK inhibitors.	Tetradecanoylphorbol Acetate	33-36	protein kinase C delta	Homo sapiens	72-75
20798497-1	2010	BACKGROUND: In this report, we explored the role of PKCalpha and PKCe as mediators of phorbol 12-myristate13-acetate (PMA)-induced proliferation in pituitary tumor GH3B6 cells, and determined if the ERK1/2 and Akt pathways were activated.	Tetradecanoylphorbol Acetate	118-121	mitogen activated protein kinase 3	Rattus norvegicus	199-205
20798497-5	2010	RESULTS: Incubation with PMA for 15 min stimulated PKCalpha and PKCe activation, which was correlated with the phosphorylation of ERK1/2 but not Akt.	Tetradecanoylphorbol Acetate	25-28	mitogen activated protein kinase 3	Rattus norvegicus	130-136
17891173-5	2008	In this study, we examined the role of Rab13 and JRAB/MICAL-L2 in the scattering of Madin-Darby canine kidney (MDCK) cells in response to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	138-174	RAB13, member RAS oncogene family	Canis lupus familiaris	39-44
17160708-2	2006	ROS generation may be induced intracellularly, in either NADPH oxidase- or mitochondria-dependent manner, by growth factors and cytokines (such as TGFbeta and HGF) and tumor promoters (such as TPA) capable of triggering cell adhesion, EMT and migration.	Tetradecanoylphorbol Acetate	193-196	hepatocyte growth factor	Homo sapiens	159-162
17891173-5	2008	In this study, we examined the role of Rab13 and JRAB/MICAL-L2 in the scattering of Madin-Darby canine kidney (MDCK) cells in response to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	138-174	MICAL like 2	Canis lupus familiaris	54-62
17891173-5	2008	In this study, we examined the role of Rab13 and JRAB/MICAL-L2 in the scattering of Madin-Darby canine kidney (MDCK) cells in response to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	176-179	MICAL like 2	Canis lupus familiaris	54-62
17891173-6	2008	Knockdown of Rab13 in canine MDCK cells suppressed the TPA-induced scattering, and this phenotype was restored by re-expression of human Rab13.	Tetradecanoylphorbol Acetate	55-58	RAB13, member RAS oncogene family	Canis lupus familiaris	13-18
17891173-7	2008	During TPA-induced MDCK cell scattering, Rab13 was transiently activated and returned to its basal level, and both Rab13 and JRAB/MICAL-L2 were colocalized with F-actin at cell-cell contact sites and then accumulated at emerging lamellipodial structures.	Tetradecanoylphorbol Acetate	7-10	RAB13, member RAS oncogene family	Canis lupus familiaris	41-46
17891173-7	2008	During TPA-induced MDCK cell scattering, Rab13 was transiently activated and returned to its basal level, and both Rab13 and JRAB/MICAL-L2 were colocalized with F-actin at cell-cell contact sites and then accumulated at emerging lamellipodial structures.	Tetradecanoylphorbol Acetate	7-10	RAB13, member RAS oncogene family	Canis lupus familiaris	115-120
17891173-7	2008	During TPA-induced MDCK cell scattering, Rab13 was transiently activated and returned to its basal level, and both Rab13 and JRAB/MICAL-L2 were colocalized with F-actin at cell-cell contact sites and then accumulated at emerging lamellipodial structures.	Tetradecanoylphorbol Acetate	7-10	MICAL like 2	Canis lupus familiaris	130-138
17891173-8	2008	TPA-induced MDCK cell scattering was also inhibited by knockdown of canine JRAB/MICAL-L2 and rescued by re-expression of mouse JRAB/MICAL-L2.	Tetradecanoylphorbol Acetate	0-3	MICAL like 2	Canis lupus familiaris	80-88
20798497-7	2010	In addition, the pretreatment with the inhibitor of ERK1/2 (PD98059) prevented the mitogenic activity induced by treatment with PMA for 15 min.	Tetradecanoylphorbol Acetate	128-131	mitogen activated protein kinase 3	Rattus norvegicus	52-58
20492173-1	2010	This study first investigates the anti-metastatic effect of alpha-mangostin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in human breast adenocarcinoma cells, MCF-7.	Tetradecanoylphorbol Acetate	117-120	matrix metallopeptidase 2	Homo sapiens	130-156
20492173-1	2010	This study first investigates the anti-metastatic effect of alpha-mangostin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in human breast adenocarcinoma cells, MCF-7.	Tetradecanoylphorbol Acetate	117-120	matrix metallopeptidase 2	Homo sapiens	158-163
20492173-3	2010	Data also showed alpha-mangostin could inhibit the activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) involved in the downregulation the enzyme activities, protein, and messenger RNA levels of MMP-2 and MMP-9 induced by TPA.	Tetradecanoylphorbol Acetate	238-241	matrix metallopeptidase 2	Homo sapiens	211-216
20492173-6	2010	Further, the treatment of specific inhibitor for ERK (U0126) to MCF-7 cells could inhibit TPA-induced MMP-2 and MMP-9 expressions along with an inhibition on cell invasion and migration.	Tetradecanoylphorbol Acetate	90-93	matrix metallopeptidase 2	Homo sapiens	102-107
20492175-0	2010	Acacetin inhibits TPA-induced MMP-2 and u-PA expressions of human lung cancer cells through inactivating JNK signaling pathway and reducing binding activities of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	18-21	matrix metallopeptidase 2	Homo sapiens	30-35
20492175-4	2010	Data also showed acacetin could inhibit phosphorylation of c-Jun N-terminal kinase 1 and 2 (JNK1/2) involved in the down-regulating protein expressions and transcriptions of matrix metalloproteinase-2 (MMP-2) and urokinase-type plasminogen activator (u-PA) induced by TPA.	Tetradecanoylphorbol Acetate	268-271	matrix metallopeptidase 2	Homo sapiens	174-200
20492175-4	2010	Data also showed acacetin could inhibit phosphorylation of c-Jun N-terminal kinase 1 and 2 (JNK1/2) involved in the down-regulating protein expressions and transcriptions of matrix metalloproteinase-2 (MMP-2) and urokinase-type plasminogen activator (u-PA) induced by TPA.	Tetradecanoylphorbol Acetate	268-271	matrix metallopeptidase 2	Homo sapiens	202-207
17116247-2	2006	Differently, we observed that CEA-TPA-CA15.3 (carcinoembryonic (CEA) tissue polypeptide (TPA) and cancer associated 115D8/DF3 (CA15.3) antigens) panel permits early detection and treatment for most relapsing patients.	Tetradecanoylphorbol Acetate	34-37	mucin 1, cell surface associated	Homo sapiens	38-44
19626033-6	2010	Unexpectedly, topical treatment of K14-RIP4 mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced dramatic, neutrophilic inflammation, an effect that was independent of tumor necrosis factor type 1 receptor (TNFR1/p55) function.	Tetradecanoylphorbol Acetate	54-90	receptor-interacting serine-threonine kinase 4	Mus musculus	39-43
19626033-6	2010	Unexpectedly, topical treatment of K14-RIP4 mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced dramatic, neutrophilic inflammation, an effect that was independent of tumor necrosis factor type 1 receptor (TNFR1/p55) function.	Tetradecanoylphorbol Acetate	92-95	receptor-interacting serine-threonine kinase 4	Mus musculus	39-43
18261747-1	2008	In the course of a project aimed to clarify the molecular mechanisms by which phorbol 12-myristate 13-acetate (PMA)-activated forms of protein kinase C (PKC) promote growth arrest in an MCF-7 cell line, we found that the PKCdelta inhibitor Rottlerin was able by itself to block cell proliferation.	Tetradecanoylphorbol Acetate	78-109	protein kinase C delta	Homo sapiens	153-156
19857463-3	2009	The megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of NRP-1 mRNA and protein expression and by an increase in VEGF-binding activity, which was mainly mediated by VEGFR-2.	Tetradecanoylphorbol Acetate	71-96	neuropilin 1	Homo sapiens	148-153
18261747-1	2008	In the course of a project aimed to clarify the molecular mechanisms by which phorbol 12-myristate 13-acetate (PMA)-activated forms of protein kinase C (PKC) promote growth arrest in an MCF-7 cell line, we found that the PKCdelta inhibitor Rottlerin was able by itself to block cell proliferation.	Tetradecanoylphorbol Acetate	78-109	protein kinase C delta	Homo sapiens	221-229
17116247-2	2006	Differently, we observed that CEA-TPA-CA15.3 (carcinoembryonic (CEA) tissue polypeptide (TPA) and cancer associated 115D8/DF3 (CA15.3) antigens) panel permits early detection and treatment for most relapsing patients.	Tetradecanoylphorbol Acetate	89-92	mucin 1, cell surface associated	Homo sapiens	38-44
18261747-1	2008	In the course of a project aimed to clarify the molecular mechanisms by which phorbol 12-myristate 13-acetate (PMA)-activated forms of protein kinase C (PKC) promote growth arrest in an MCF-7 cell line, we found that the PKCdelta inhibitor Rottlerin was able by itself to block cell proliferation.	Tetradecanoylphorbol Acetate	111-114	protein kinase C delta	Homo sapiens	153-156
19857463-3	2009	The megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of NRP-1 mRNA and protein expression and by an increase in VEGF-binding activity, which was mainly mediated by VEGFR-2.	Tetradecanoylphorbol Acetate	98-101	neuropilin 1	Homo sapiens	148-153
18261747-1	2008	In the course of a project aimed to clarify the molecular mechanisms by which phorbol 12-myristate 13-acetate (PMA)-activated forms of protein kinase C (PKC) promote growth arrest in an MCF-7 cell line, we found that the PKCdelta inhibitor Rottlerin was able by itself to block cell proliferation.	Tetradecanoylphorbol Acetate	111-114	protein kinase C delta	Homo sapiens	221-229
19715751-2	2009	In a previous study, we reported that silibinin suppresses TPA-induced MMP-9 expression through the Raf/MEK/ERK pathway.	Tetradecanoylphorbol Acetate	59-62	zinc fingers and homeoboxes 2	Homo sapiens	100-103
18174170-3	2008	Moreover, NIH3T3 cells expressing the 4 CRUs of Ahnak showed enhanced c-Raf, MEK, and Erk phosphorylation in response to phorbol 12-myristate 13-acetate (PMA) compared with parental cells.	Tetradecanoylphorbol Acetate	121-152	midkine	Mus musculus	77-80
17116247-10	2006	Sensitivity of CEA-TPA-CA15.3 panel was 74% (14 of 19 recurrences).	Tetradecanoylphorbol Acetate	19-22	mucin 1, cell surface associated	Homo sapiens	23-29
16949567-1	2006	The extracellular serine protease, plasmin, is activated from its precursor, plasminogen (Plg), by the urokinase-type and tissue-type Plg activators (uPA and tPA respectively).	Tetradecanoylphorbol Acetate	158-161	plasminogen	Mus musculus	77-88
18174170-3	2008	Moreover, NIH3T3 cells expressing the 4 CRUs of Ahnak showed enhanced c-Raf, MEK, and Erk phosphorylation in response to phorbol 12-myristate 13-acetate (PMA) compared with parental cells.	Tetradecanoylphorbol Acetate	154-157	midkine	Mus musculus	77-80
19017354-5	2009	In K562 cells, expression of miR-223 was down-regulated during haemin-induced erythroid differentiation but up-regulated during phorbol myristate acetate (PMA)-induced megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	128-153	microRNA 223	Homo sapiens	29-36
19017354-5	2009	In K562 cells, expression of miR-223 was down-regulated during haemin-induced erythroid differentiation but up-regulated during phorbol myristate acetate (PMA)-induced megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	155-158	microRNA 223	Homo sapiens	29-36
16949567-1	2006	The extracellular serine protease, plasmin, is activated from its precursor, plasminogen (Plg), by the urokinase-type and tissue-type Plg activators (uPA and tPA respectively).	Tetradecanoylphorbol Acetate	158-161	plasminogen	Mus musculus	90-93
17162651-6	2006	Zymography demonstrated in vitro secretion of MMP-2 by uninduced human lung carcinoma cells and both MMP-2 and -9 by phorbol 12-mysristate 13-acetate (PMA) (200 ng/mL)-treated cells.	Tetradecanoylphorbol Acetate	151-154	matrix metallopeptidase 2	Homo sapiens	46-51
19633291-3	2009	Our data further reveal that TPA activates transcription of TBX2 through activating MSK1, which leads to an increase in phosphorylated histone H3 and the recruitment of Sp1 to the TBX2 gene.	Tetradecanoylphorbol Acetate	29-32	ribosomal protein S6 kinase A5	Homo sapiens	84-88
19633291-4	2009	In addition, TPA was shown to activate MSK1 in a PKC-dependent and MAPK-independent manner.	Tetradecanoylphorbol Acetate	13-16	ribosomal protein S6 kinase A5	Homo sapiens	39-43
17162651-6	2006	Zymography demonstrated in vitro secretion of MMP-2 by uninduced human lung carcinoma cells and both MMP-2 and -9 by phorbol 12-mysristate 13-acetate (PMA) (200 ng/mL)-treated cells.	Tetradecanoylphorbol Acetate	151-154	matrix metallopeptidase 2	Homo sapiens	101-113
16914136-3	2006	In the presence of 10 muM A23187, 100 nM phorbol myristate acetate (PMA) and 1 mM H(2)O(2) synergistically stimulated arachidonic acid release from L929 cells and C12-cPLA(2)alpha cells, and to a much lesser extent from C12 cells.	Tetradecanoylphorbol Acetate	41-66	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	167-179
19596270-7	2009	Pro-IL-33 was expressed by stimulating human epithelial cells with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	67-98	interleukin 33	Homo sapiens	4-9
16914136-3	2006	In the presence of 10 muM A23187, 100 nM phorbol myristate acetate (PMA) and 1 mM H(2)O(2) synergistically stimulated arachidonic acid release from L929 cells and C12-cPLA(2)alpha cells, and to a much lesser extent from C12 cells.	Tetradecanoylphorbol Acetate	68-71	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	167-179
19343040-6	2009	The phosphorylation of this residue is operated by the protein kinase C (PKC), as S193 phosphorylation is markedly increased by treatment with 12-O-tetradecanoylphorbol-13-acetate and decreased by inhibition of PKCalpha and PKCbeta.	Tetradecanoylphorbol Acetate	143-179	protein kinase C beta	Homo sapiens	224-231
16720310-5	2006	The gene coding for CRH-R1 generates multiple isoforms through a process modulated by UVR, cyclic adenosine monophosphate (cAMP) and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	133-164	corticotropin releasing hormone receptor 1	Homo sapiens	20-26
19525381-9	2009	Western blotting showed that CCPA, phenylisopropyladenosine, and phorbol 12-myristate 13-acetate in the rat heart increased the PKC-epsilon co-IP with RACK2 by 186, 49, and &gt;1,000%, respectively.	Tetradecanoylphorbol Acetate	65-96	protein kinase C, epsilon	Mus musculus	128-139
16846840-10	2006	Our data suggest that one of the mechanisms by which HIV-1 gp120 up-regulates the MOR in TPA-differentiated HL-60 cells is through autocrine/paracrine actions of TNF-alpha via the TNFR-II receptor.	Tetradecanoylphorbol Acetate	89-92	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	59-64
19723084-1	2009	The topical application of TPA (12-O-tetradecanoylphorbol-13-acetate) to animal skin or direct treatment of TPA to cell cultures leads to inflammatory responses by enhancing cyclooxygenase 2 (COX-2) expression, and specific COX-2 inhibitors counteract this kind of inflammatory response.	Tetradecanoylphorbol Acetate	27-30	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	174-190
16804093-5	2006	These results were paralleled in human platelets, in which PMA reduced subsequent ADP-induced P2Y1 and P2Y12 receptor signaling.	Tetradecanoylphorbol Acetate	59-62	purinergic receptor P2Y12	Homo sapiens	103-108
19723084-1	2009	The topical application of TPA (12-O-tetradecanoylphorbol-13-acetate) to animal skin or direct treatment of TPA to cell cultures leads to inflammatory responses by enhancing cyclooxygenase 2 (COX-2) expression, and specific COX-2 inhibitors counteract this kind of inflammatory response.	Tetradecanoylphorbol Acetate	27-30	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	192-197
19723084-1	2009	The topical application of TPA (12-O-tetradecanoylphorbol-13-acetate) to animal skin or direct treatment of TPA to cell cultures leads to inflammatory responses by enhancing cyclooxygenase 2 (COX-2) expression, and specific COX-2 inhibitors counteract this kind of inflammatory response.	Tetradecanoylphorbol Acetate	27-30	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	224-229
19723084-1	2009	The topical application of TPA (12-O-tetradecanoylphorbol-13-acetate) to animal skin or direct treatment of TPA to cell cultures leads to inflammatory responses by enhancing cyclooxygenase 2 (COX-2) expression, and specific COX-2 inhibitors counteract this kind of inflammatory response.	Tetradecanoylphorbol Acetate	32-68	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	174-190
19723084-1	2009	The topical application of TPA (12-O-tetradecanoylphorbol-13-acetate) to animal skin or direct treatment of TPA to cell cultures leads to inflammatory responses by enhancing cyclooxygenase 2 (COX-2) expression, and specific COX-2 inhibitors counteract this kind of inflammatory response.	Tetradecanoylphorbol Acetate	32-68	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	192-197
16911517-6	2006	On the other hand, cell stimulation with phorbol 12-myristate 13-acetate (PMA), an activator of Nox1-3, facilitates membrane translocation of Noxo1gamma; as a result, Noxo1gamma is equivalent to Noxo1beta in Nox1 activation in PMA-stimulated cells.	Tetradecanoylphorbol Acetate	41-72	NADPH oxidase 1	Homo sapiens	96-102
19723084-1	2009	The topical application of TPA (12-O-tetradecanoylphorbol-13-acetate) to animal skin or direct treatment of TPA to cell cultures leads to inflammatory responses by enhancing cyclooxygenase 2 (COX-2) expression, and specific COX-2 inhibitors counteract this kind of inflammatory response.	Tetradecanoylphorbol Acetate	32-68	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	224-229
19723084-1	2009	The topical application of TPA (12-O-tetradecanoylphorbol-13-acetate) to animal skin or direct treatment of TPA to cell cultures leads to inflammatory responses by enhancing cyclooxygenase 2 (COX-2) expression, and specific COX-2 inhibitors counteract this kind of inflammatory response.	Tetradecanoylphorbol Acetate	108-111	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	174-190
19723084-1	2009	The topical application of TPA (12-O-tetradecanoylphorbol-13-acetate) to animal skin or direct treatment of TPA to cell cultures leads to inflammatory responses by enhancing cyclooxygenase 2 (COX-2) expression, and specific COX-2 inhibitors counteract this kind of inflammatory response.	Tetradecanoylphorbol Acetate	108-111	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	192-197
19723084-1	2009	The topical application of TPA (12-O-tetradecanoylphorbol-13-acetate) to animal skin or direct treatment of TPA to cell cultures leads to inflammatory responses by enhancing cyclooxygenase 2 (COX-2) expression, and specific COX-2 inhibitors counteract this kind of inflammatory response.	Tetradecanoylphorbol Acetate	108-111	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	224-229
19723105-0	2009	Effects of cotreatment of 12-O-tetradecanoylphorbol-13-acetate and H2O2 on apoptotic regulation via AMP-activated protein kinase-cyclooxygenase-2 signals.	Tetradecanoylphorbol Acetate	26-62	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	100-128
19723105-8	2009	The present findings suggest that both COX-2 stimulators (TPA and H(2)O(2)) might have differential effects on COX-2 and AMPK regulation and further apoptotic regulation.	Tetradecanoylphorbol Acetate	58-61	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	121-125
19458037-2	2009	We previously demonstrated that phospholipase C (PLC)epsilon, an effector of Ras and Rap small GTPases, plays a crucial role in two-stage skin chemical carcinogenesis using 12-O-tetradecanoyl-phorbor-13-acetate (TPA) as a promoter through augmentation of TPA-induced inflammation.	Tetradecanoylphorbol Acetate	212-215	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	49-52
16911517-6	2006	On the other hand, cell stimulation with phorbol 12-myristate 13-acetate (PMA), an activator of Nox1-3, facilitates membrane translocation of Noxo1gamma; as a result, Noxo1gamma is equivalent to Noxo1beta in Nox1 activation in PMA-stimulated cells.	Tetradecanoylphorbol Acetate	41-72	NADPH oxidase 1	Homo sapiens	96-100
16911517-6	2006	On the other hand, cell stimulation with phorbol 12-myristate 13-acetate (PMA), an activator of Nox1-3, facilitates membrane translocation of Noxo1gamma; as a result, Noxo1gamma is equivalent to Noxo1beta in Nox1 activation in PMA-stimulated cells.	Tetradecanoylphorbol Acetate	74-77	NADPH oxidase 1	Homo sapiens	96-102
19470390-5	2009	KEY FINDINGS: Farnesol at both the low doses significantly reduced the TPA-induced skin edema, hyperplasia, expression of COX-2 and oxidative stress response.	Tetradecanoylphorbol Acetate	71-74	prostaglandin-endoperoxide synthase 2	Mus musculus	122-127
16911517-6	2006	On the other hand, cell stimulation with phorbol 12-myristate 13-acetate (PMA), an activator of Nox1-3, facilitates membrane translocation of Noxo1gamma; as a result, Noxo1gamma is equivalent to Noxo1beta in Nox1 activation in PMA-stimulated cells.	Tetradecanoylphorbol Acetate	74-77	NADPH oxidase 1	Homo sapiens	96-100
19420016-7	2009	Treatment with the protein kinase C (PKC)delta inhibitor rottlerin caused a marked decrease in PMA-induced MMP-9 secretion and cell invasion, as well as ERK/AP-1 activation, and KPS-A reduced PMA-induced membrane localization of PKCdelta.	Tetradecanoylphorbol Acetate	95-98	protein kinase C delta	Homo sapiens	37-46
16679718-4	2006	Fas and caspase-3 mRNA expression was inhibited by 8br-cAMP and PMA but was increased by A23187 (P&lt;0.05).	Tetradecanoylphorbol Acetate	64-67	caspase 3	Bos taurus	8-17
19420016-7	2009	Treatment with the protein kinase C (PKC)delta inhibitor rottlerin caused a marked decrease in PMA-induced MMP-9 secretion and cell invasion, as well as ERK/AP-1 activation, and KPS-A reduced PMA-induced membrane localization of PKCdelta.	Tetradecanoylphorbol Acetate	95-98	protein kinase C delta	Homo sapiens	229-237
19420016-7	2009	Treatment with the protein kinase C (PKC)delta inhibitor rottlerin caused a marked decrease in PMA-induced MMP-9 secretion and cell invasion, as well as ERK/AP-1 activation, and KPS-A reduced PMA-induced membrane localization of PKCdelta.	Tetradecanoylphorbol Acetate	192-195	protein kinase C delta	Homo sapiens	37-46
19420016-7	2009	Treatment with the protein kinase C (PKC)delta inhibitor rottlerin caused a marked decrease in PMA-induced MMP-9 secretion and cell invasion, as well as ERK/AP-1 activation, and KPS-A reduced PMA-induced membrane localization of PKCdelta.	Tetradecanoylphorbol Acetate	192-195	protein kinase C delta	Homo sapiens	229-237
19420016-9	2009	These results suggest that KPS-A inhibits PMA-induced invasion by reducing MMP-9 activation, mainly via the PI3K/Akt/NF-kappaB and PKCdelta/ERK/AP-1 pathways in MCF-7 cells and blocks tumor growth and MMP-9-mediated invasiveness in mice with breast carcinoma.	Tetradecanoylphorbol Acetate	42-45	protein kinase C delta	Homo sapiens	131-139
16169661-0	2006	Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	78-81	zinc fingers and homeoboxes 2	Homo sapiens	39-42
19542437-6	2009	By contrast, the transcript of IL-27EBI3 was induced in the iNKT cells upon stimulation with PMA plus ionomycin in vitro and with alpha-GalCer treatment in vivo, suggesting that IL-27 (p28/EBI3) could be produced by iNKT cells in an activation-dependent manner.	Tetradecanoylphorbol Acetate	93-96	glutathione S-transferase omega 1	Mus musculus	185-188
16910781-4	2006	12-O-Tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C and an inducer of NFkappaB and AP-1, protected the cells.	Tetradecanoylphorbol Acetate	0-36	jun proto-oncogene	Mus musculus	108-112
16910781-4	2006	12-O-Tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C and an inducer of NFkappaB and AP-1, protected the cells.	Tetradecanoylphorbol Acetate	38-41	jun proto-oncogene	Mus musculus	108-112
16669786-5	2006	Despite this robust interaction, analysis of the PMA-induced proteasome-dependent degradation of PKCdelta in different RCC (renal cell carcinoma) lines (RCC4, UMRC2 and 786 O) shows that there is no correlation between the degradation of PKCdelta and the presence of active pVHL.	Tetradecanoylphorbol Acetate	49-52	protein kinase C delta	Homo sapiens	97-105
19609061-5	2009	The expression of the Th2-inducing cytokine thymic stromal lymphopoietin (TSLP) mRNA was also increased by TPA.	Tetradecanoylphorbol Acetate	107-110	thymic stromal lymphopoietin	Mus musculus	44-72
19609061-5	2009	The expression of the Th2-inducing cytokine thymic stromal lymphopoietin (TSLP) mRNA was also increased by TPA.	Tetradecanoylphorbol Acetate	107-110	thymic stromal lymphopoietin	Mus musculus	74-78
19366211-5	2009	A T141D substitution markedly increases basal lipid-independent PKCdelta activity; the PKCdelta-T141D mutant is only slightly further stimulated in vitro by PMA treatment, suggesting that Thr(141) phosphorylation relieves autoinhibitory constraints that limit PKCdelta activity.	Tetradecanoylphorbol Acetate	157-160	protein kinase C delta	Homo sapiens	87-95
19366211-5	2009	A T141D substitution markedly increases basal lipid-independent PKCdelta activity; the PKCdelta-T141D mutant is only slightly further stimulated in vitro by PMA treatment, suggesting that Thr(141) phosphorylation relieves autoinhibitory constraints that limit PKCdelta activity.	Tetradecanoylphorbol Acetate	157-160	protein kinase C delta	Homo sapiens	87-95
16669786-5	2006	Despite this robust interaction, analysis of the PMA-induced proteasome-dependent degradation of PKCdelta in different RCC (renal cell carcinoma) lines (RCC4, UMRC2 and 786 O) shows that there is no correlation between the degradation of PKCdelta and the presence of active pVHL.	Tetradecanoylphorbol Acetate	49-52	solute carrier family 49 member 4	Homo sapiens	153-157
16474181-3	2006	In the present study, we found that topically applied resveratrol significantly inhibited COX-2 expression induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	137-173	prostaglandin-endoperoxide synthase 2	Mus musculus	90-95
16474181-3	2006	In the present study, we found that topically applied resveratrol significantly inhibited COX-2 expression induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	175-178	prostaglandin-endoperoxide synthase 2	Mus musculus	90-95
16474181-7	2006	To get further insights into the molecular basis of NF-kappaB inactivation by resveratrol, we examined the role of IkappaB kinase (IKK) in mediating TPA-induced activation of NF-kappaB and COX-2 expression.	Tetradecanoylphorbol Acetate	149-152	prostaglandin-endoperoxide synthase 2	Mus musculus	189-194
19235605-4	2009	Cell treatment with phorbol 12-myristate 13-acetate (PMA) plus ionomycin or the CD3 mAb OKT3 plus intercellular cell adhesion molecule-1 (ICAM-1) at 37 degrees C for 6 h induced a dramatic increase in CD25, CD69 and MEM148 epitope exposure.	Tetradecanoylphorbol Acetate	20-51	CD69 antigen	Mus musculus	207-211
16474181-9	2006	Topical application of Bay 11-7082 also abrogated TPA-induced NF-kappaB activation and COX-2 expression, supporting the involvement of IKK in TPA-induced COX-2 expression.	Tetradecanoylphorbol Acetate	50-53	prostaglandin-endoperoxide synthase 2	Mus musculus	87-92
16474181-9	2006	Topical application of Bay 11-7082 also abrogated TPA-induced NF-kappaB activation and COX-2 expression, supporting the involvement of IKK in TPA-induced COX-2 expression.	Tetradecanoylphorbol Acetate	50-53	prostaglandin-endoperoxide synthase 2	Mus musculus	154-159
16474181-9	2006	Topical application of Bay 11-7082 also abrogated TPA-induced NF-kappaB activation and COX-2 expression, supporting the involvement of IKK in TPA-induced COX-2 expression.	Tetradecanoylphorbol Acetate	142-145	prostaglandin-endoperoxide synthase 2	Mus musculus	154-159
16636047-6	2006	In U937 cells exposed to TPA, these proteolytic events can be inhibited by expression of a caspase-8 dominant negative mutant or the cowpox virus CrmA caspase inhibitor.	Tetradecanoylphorbol Acetate	25-28	caspase 8	Homo sapiens	91-100
19181503-10	2009	Taken together, we suggest that the inhibition of TPA-induced MMP-9 and VEGF expression by silibinin is mediated by the suppression of the Raf/MEK/ERK pathway in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	50-53	zinc fingers and homeoboxes 2	Homo sapiens	139-142
18089565-3	2008	In this study, we show that phorbol ester (PMA)-induced internalization of the LPA(1) receptor requires clathrin AP-2 complexes, protein kinase C, and a distal dileucine motif (amino acids 352 and 353) in the cytoplasmic tail but not beta-arrestin.	Tetradecanoylphorbol Acetate	43-46	transcription factor AP-2, alpha	Mus musculus	113-117
16373587-5	2006	PKC activation by 12-O-tetradecanoylphorbol 13-acetate treatment increased serine phosphorylation of FAK and FRNK.	Tetradecanoylphorbol Acetate	18-54	protein tyrosine kinase 2	Homo sapiens	101-104
18089565-7	2008	Evidence for the beta-arrestin independence of PMA-induced internalization of LPA 1 comes from the observations that beta-arrestin2-GFP is not recruited to the plasma membrane upon PMA treatment and that LPA 1 is readily internalized in beta-arrestin1/2 knock-out mouse embryonic fibroblasts.	Tetradecanoylphorbol Acetate	47-50	arrestin, beta 1	Mus musculus	237-251
19375915-5	2009	Apparently, phorbol myristate acetate (PMA) stimulated expressions of ERK, JNK and p38 were altered in the presence of potent tumour inducer, phorbol myristate acetate QAGlc, suggesting their suppression also contributes to QAGlc-mediated inhibition of MMP-9 and MMP-2.	Tetradecanoylphorbol Acetate	12-37	matrix metallopeptidase 2	Homo sapiens	263-268
19375915-5	2009	Apparently, phorbol myristate acetate (PMA) stimulated expressions of ERK, JNK and p38 were altered in the presence of potent tumour inducer, phorbol myristate acetate QAGlc, suggesting their suppression also contributes to QAGlc-mediated inhibition of MMP-9 and MMP-2.	Tetradecanoylphorbol Acetate	39-42	matrix metallopeptidase 2	Homo sapiens	263-268
19375915-5	2009	Apparently, phorbol myristate acetate (PMA) stimulated expressions of ERK, JNK and p38 were altered in the presence of potent tumour inducer, phorbol myristate acetate QAGlc, suggesting their suppression also contributes to QAGlc-mediated inhibition of MMP-9 and MMP-2.	Tetradecanoylphorbol Acetate	142-167	matrix metallopeptidase 2	Homo sapiens	263-268
16740738-6	2006	Importantly, knockdown of paxillin inhibited EGF- or TPA-induced c-Jun phosphorylation at Ser(63) and Ser(73).	Tetradecanoylphorbol Acetate	53-56	jun proto-oncogene	Mus musculus	65-70
19279011-7	2009	Glucosylceramide levels declined after treatment of MCF-7 cells with a potent PKC activator, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	93-124	protein kinase C delta	Homo sapiens	78-81
18198130-0	2008	Induction of proline-rich tyrosine kinase2 (Pyk2) through C/EBPbeta is involved in PMA-induced monocyte differentiation.	Tetradecanoylphorbol Acetate	83-86	CCAAT enhancer binding protein beta	Homo sapiens	58-67
16776680-11	2006	Alginic acid also inhibited HDC expression and activity on the phorbol myristate acetate (PMA)+A23187-stimulated human mast cell line, HMC-1 cells.	Tetradecanoylphorbol Acetate	63-88	histidine decarboxylase	Homo sapiens	28-31
18053801-3	2008	VPA inhibited HGF production in fibroblasts induced by epidermal growth factor (EGF), platelet-derived growth factor, basic fibroblast growth factor, phorbol 12-myristate 13-acetate (PMA) and prostaglandin E(2) without any appreciable cytotoxic effect.	Tetradecanoylphorbol Acetate	150-181	hepatocyte growth factor	Homo sapiens	14-17
19279011-7	2009	Glucosylceramide levels declined after treatment of MCF-7 cells with a potent PKC activator, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	126-129	protein kinase C delta	Homo sapiens	78-81
16776680-11	2006	Alginic acid also inhibited HDC expression and activity on the phorbol myristate acetate (PMA)+A23187-stimulated human mast cell line, HMC-1 cells.	Tetradecanoylphorbol Acetate	90-93	histidine decarboxylase	Homo sapiens	28-31
19168130-6	2009	Following induction of PKCepsilonA/E-expression by doxycycline for 24 h and additional short-term treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), PKCepsilonA/E translocated to the plasma membrane and increased phosphorylation of MARCKS(S152/156).	Tetradecanoylphorbol Acetate	113-149	myristoylated alanine rich protein kinase C substrate	Homo sapiens	240-246
18053806-6	2008	MEK kinase assay using myelin basic protein (MBP) revealed that TPA-augmented MEK activity in HT-1080 cells and that the augmented MEK activity was diminished by nobiletin treatment.	Tetradecanoylphorbol Acetate	64-67	myelin basic protein	Homo sapiens	23-43
18053806-6	2008	MEK kinase assay using myelin basic protein (MBP) revealed that TPA-augmented MEK activity in HT-1080 cells and that the augmented MEK activity was diminished by nobiletin treatment.	Tetradecanoylphorbol Acetate	64-67	myelin basic protein	Homo sapiens	45-48
19168130-7	2009	Treatment with doxycycline/TPA or TPA alone increased phosphorylations of Elk-1(S383), PDK1(S241), Rb(S807/S811), PKCdelta(T505), p38MAPK(T180/Y182), MEK1/2(S217/S221) and ERK2(T185/T187).	Tetradecanoylphorbol Acetate	27-30	protein kinase C delta	Homo sapiens	114-127
16859115-11	2006	PMA could enhance the effects of NGF.	Tetradecanoylphorbol Acetate	0-3	nerve growth factor	Rattus norvegicus	33-36
19168130-7	2009	Treatment with doxycycline/TPA or TPA alone increased phosphorylations of Elk-1(S383), PDK1(S241), Rb(S807/S811), PKCdelta(T505), p38MAPK(T180/Y182), MEK1/2(S217/S221) and ERK2(T185/T187).	Tetradecanoylphorbol Acetate	34-37	protein kinase C delta	Homo sapiens	114-127
19168130-8	2009	MARCKS was not phosphorylated after treatment with TPA alone, demonstrating that in this system it is phosphorylated only by PKCepsilon localized to the plasma membrane but not by PKCalpha or delta, the other TPA-responsive PKC isozymes in HeLa cells.	Tetradecanoylphorbol Acetate	51-54	myristoylated alanine rich protein kinase C substrate	Homo sapiens	0-6
19168130-8	2009	MARCKS was not phosphorylated after treatment with TPA alone, demonstrating that in this system it is phosphorylated only by PKCepsilon localized to the plasma membrane but not by PKCalpha or delta, the other TPA-responsive PKC isozymes in HeLa cells.	Tetradecanoylphorbol Acetate	209-212	myristoylated alanine rich protein kinase C substrate	Homo sapiens	0-6
19130490-7	2009	Using pharmacological inhibitors and small interfering (si)RNA we found that PKCdelta is indispensably involved in the TPA-triggered MMP-9 expression.	Tetradecanoylphorbol Acetate	119-122	protein kinase C delta	Homo sapiens	77-85
19130490-8	2009	Concomitantly, the TPA-evoked increase in total PKC activity was strongly attenuated in the lysates from NO-treated MCF-7 cells, thus suggesting that NO attenuates TPA-triggered MMP-9 mainly through a direct inhibition of PKCdelta.	Tetradecanoylphorbol Acetate	19-22	protein kinase C delta	Homo sapiens	48-51
19130490-8	2009	Concomitantly, the TPA-evoked increase in total PKC activity was strongly attenuated in the lysates from NO-treated MCF-7 cells, thus suggesting that NO attenuates TPA-triggered MMP-9 mainly through a direct inhibition of PKCdelta.	Tetradecanoylphorbol Acetate	19-22	protein kinase C delta	Homo sapiens	222-230
19130490-8	2009	Concomitantly, the TPA-evoked increase in total PKC activity was strongly attenuated in the lysates from NO-treated MCF-7 cells, thus suggesting that NO attenuates TPA-triggered MMP-9 mainly through a direct inhibition of PKCdelta.	Tetradecanoylphorbol Acetate	164-167	protein kinase C delta	Homo sapiens	48-51
19130490-8	2009	Concomitantly, the TPA-evoked increase in total PKC activity was strongly attenuated in the lysates from NO-treated MCF-7 cells, thus suggesting that NO attenuates TPA-triggered MMP-9 mainly through a direct inhibition of PKCdelta.	Tetradecanoylphorbol Acetate	164-167	protein kinase C delta	Homo sapiens	222-230
19289499-5	2009	The newly identified kappaB site in the BECN1 promoter specifically interacts with p65 both in vitro and in living Jurkat cells upon phorbol myristate acetate (PMA)-ionomycin stimulation, where p65 induction is coupled to BECN1 upregulation and autophagy induction.	Tetradecanoylphorbol Acetate	133-158	RELA proto-oncogene, NF-kB subunit	Homo sapiens	83-86
19289499-5	2009	The newly identified kappaB site in the BECN1 promoter specifically interacts with p65 both in vitro and in living Jurkat cells upon phorbol myristate acetate (PMA)-ionomycin stimulation, where p65 induction is coupled to BECN1 upregulation and autophagy induction.	Tetradecanoylphorbol Acetate	133-158	RELA proto-oncogene, NF-kB subunit	Homo sapiens	194-197
19289499-5	2009	The newly identified kappaB site in the BECN1 promoter specifically interacts with p65 both in vitro and in living Jurkat cells upon phorbol myristate acetate (PMA)-ionomycin stimulation, where p65 induction is coupled to BECN1 upregulation and autophagy induction.	Tetradecanoylphorbol Acetate	160-163	RELA proto-oncogene, NF-kB subunit	Homo sapiens	83-86
19289499-5	2009	The newly identified kappaB site in the BECN1 promoter specifically interacts with p65 both in vitro and in living Jurkat cells upon phorbol myristate acetate (PMA)-ionomycin stimulation, where p65 induction is coupled to BECN1 upregulation and autophagy induction.	Tetradecanoylphorbol Acetate	160-163	RELA proto-oncogene, NF-kB subunit	Homo sapiens	194-197
19360311-2	2009	Expression of MMPs is highly regulated by cytokines and signal transducation pathways, including those activated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	116-147	matrix metallopeptidase 2	Homo sapiens	14-18
19360311-2	2009	Expression of MMPs is highly regulated by cytokines and signal transducation pathways, including those activated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	149-152	matrix metallopeptidase 2	Homo sapiens	14-18
19258009-3	2009	The tumor-promoting phorbol ester TPA strongly inhibits Cx43 gap junction channels.	Tetradecanoylphorbol Acetate	34-37	gap junction protein alpha 1	Homo sapiens	56-60
19258009-4	2009	In this study we have investigated mechanisms involved in TPA-induced phosphorylation of Cx43 and inhibition of gap junction channels.	Tetradecanoylphorbol Acetate	58-61	gap junction protein alpha 1	Homo sapiens	89-93
19258009-6	2009	The data suggest that PKC-induced activation of MAP kinase partly involves Src-independent trans-activation of the EGF receptor, and that TPA-induced shift in SDS-PAGE gel mobility of Cx43 is caused by MAP kinase phosphorylation, whereas phosphorylation of S368 by PKC does not alter gel migration of Cx43.	Tetradecanoylphorbol Acetate	138-141	gap junction protein alpha 1	Homo sapiens	184-188
19258009-6	2009	The data suggest that PKC-induced activation of MAP kinase partly involves Src-independent trans-activation of the EGF receptor, and that TPA-induced shift in SDS-PAGE gel mobility of Cx43 is caused by MAP kinase phosphorylation, whereas phosphorylation of S368 by PKC does not alter gel migration of Cx43.	Tetradecanoylphorbol Acetate	138-141	gap junction protein alpha 1	Homo sapiens	301-305
19233874-2	2009	JDP2 binds TPA response element and cyclic AMP response element located within various promoters.	Tetradecanoylphorbol Acetate	11-14	Jun dimerization protein 2	Mus musculus	0-4
19187225-6	2009	In addition, E2A deficiency-linked BCR signaling controls the mimicked pre-mature B-cell apoptosis by PMA/ionomycin through elevated survivin plus inhibitor of apoptosis 2 levels, and reduced caspase-3 and caspase-8 activities, resulting in increased amounts of ICAD (inhibitor of caspase-activated DNase), compared with those in the presence of E2A, followed by reduction of DNA fragmentation.	Tetradecanoylphorbol Acetate	102-105	baculoviral IAP repeat containing 5	Gallus gallus	133-141
19258426-5	2009	Pretreatment with NSC 676914 is here shown to repress 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IkappaB-alpha phosphorylation and translocation of p65/50 to the nucleus but not the processing of p52 from p100, suggesting the inhibition of NF-kappaB regulator IKKbeta rather than IKKalpha.	Tetradecanoylphorbol Acetate	54-90	RELA proto-oncogene, NF-kB subunit	Homo sapiens	156-159
19258426-5	2009	Pretreatment with NSC 676914 is here shown to repress 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IkappaB-alpha phosphorylation and translocation of p65/50 to the nucleus but not the processing of p52 from p100, suggesting the inhibition of NF-kappaB regulator IKKbeta rather than IKKalpha.	Tetradecanoylphorbol Acetate	92-95	RELA proto-oncogene, NF-kB subunit	Homo sapiens	156-159
18987998-7	2009	In contrast, PKC activator phorbol-12-myristate-13-acetate reduced OCIL expression in short term but induced OCIL mRNA in long term.	Tetradecanoylphorbol Acetate	27-58	C-type lectin domain family 2, member D	Rattus norvegicus	67-71
18987998-7	2009	In contrast, PKC activator phorbol-12-myristate-13-acetate reduced OCIL expression in short term but induced OCIL mRNA in long term.	Tetradecanoylphorbol Acetate	27-58	C-type lectin domain family 2, member D	Rattus norvegicus	109-113
18820286-3	2008	We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin.	Tetradecanoylphorbol Acetate	71-107	cytochrome c oxidase II, mitochondrial	Mus musculus	182-204
18820286-3	2008	We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin.	Tetradecanoylphorbol Acetate	109-112	cytochrome c oxidase II, mitochondrial	Mus musculus	182-204
18820286-7	2008	Moreover, DDMN suppressed TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, phosphatidylinositol 3-kinase/Akt and protein kinase C that are upstream of NF-kappaB and activator protien-1.	Tetradecanoylphorbol Acetate	26-29	mitogen-activated protein kinase 3	Mus musculus	52-93
18820286-7	2008	Moreover, DDMN suppressed TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, phosphatidylinositol 3-kinase/Akt and protein kinase C that are upstream of NF-kappaB and activator protien-1.	Tetradecanoylphorbol Acetate	26-29	mitogen-activated protein kinase 14	Mus musculus	95-98
18719353-6	2008	Dominant-negative RhoA and Rac1 (but not Cdc42Hs) inhibited the TPA-Ras synergy by blocking the Ras-Rho-SRF signaling pathway.	Tetradecanoylphorbol Acetate	64-67	ras homolog family member A	Mus musculus	18-22
18719353-6	2008	Dominant-negative RhoA and Rac1 (but not Cdc42Hs) inhibited the TPA-Ras synergy by blocking the Ras-Rho-SRF signaling pathway.	Tetradecanoylphorbol Acetate	64-67	Rac family small GTPase 1	Mus musculus	27-31
18719353-6	2008	Dominant-negative RhoA and Rac1 (but not Cdc42Hs) inhibited the TPA-Ras synergy by blocking the Ras-Rho-SRF signaling pathway.	Tetradecanoylphorbol Acetate	64-67	serum response factor	Mus musculus	104-107
18719353-8	2008	These results suggest that the activation of two distinct pathways such as Ras-Raf-ERK-TCF pathway and Rho-SRF pathway are responsible for the induction of c-fos by TPA and Ras in mitogenic signaling pathways.	Tetradecanoylphorbol Acetate	165-168	serum response factor	Mus musculus	107-110
19011111-4	2008	Here, we demonstrate that Par-1b is also regulated by another arm of the PKC pathway, one that involves novel PKCs (nPKC) and protein kinase D. Treatment of cells with the PKC activator phorbol-12-myristate-13-acetate (PMA) potently stimulated phosphorylation of Par-1b on serine 400 (S400), a residue that is conserved in all 4 mammalian Par-1 kinases as well as the fly ortholog.	Tetradecanoylphorbol Acetate	186-217	microtubule affinity regulating kinase 2	Homo sapiens	26-32
19011111-4	2008	Here, we demonstrate that Par-1b is also regulated by another arm of the PKC pathway, one that involves novel PKCs (nPKC) and protein kinase D. Treatment of cells with the PKC activator phorbol-12-myristate-13-acetate (PMA) potently stimulated phosphorylation of Par-1b on serine 400 (S400), a residue that is conserved in all 4 mammalian Par-1 kinases as well as the fly ortholog.	Tetradecanoylphorbol Acetate	186-217	microtubule affinity regulating kinase 2	Homo sapiens	263-269
19011111-4	2008	Here, we demonstrate that Par-1b is also regulated by another arm of the PKC pathway, one that involves novel PKCs (nPKC) and protein kinase D. Treatment of cells with the PKC activator phorbol-12-myristate-13-acetate (PMA) potently stimulated phosphorylation of Par-1b on serine 400 (S400), a residue that is conserved in all 4 mammalian Par-1 kinases as well as the fly ortholog.	Tetradecanoylphorbol Acetate	186-217	microtubule affinity regulating kinase 2	Homo sapiens	26-31
19011111-4	2008	Here, we demonstrate that Par-1b is also regulated by another arm of the PKC pathway, one that involves novel PKCs (nPKC) and protein kinase D. Treatment of cells with the PKC activator phorbol-12-myristate-13-acetate (PMA) potently stimulated phosphorylation of Par-1b on serine 400 (S400), a residue that is conserved in all 4 mammalian Par-1 kinases as well as the fly ortholog.	Tetradecanoylphorbol Acetate	219-222	microtubule affinity regulating kinase 2	Homo sapiens	26-32
19011111-4	2008	Here, we demonstrate that Par-1b is also regulated by another arm of the PKC pathway, one that involves novel PKCs (nPKC) and protein kinase D. Treatment of cells with the PKC activator phorbol-12-myristate-13-acetate (PMA) potently stimulated phosphorylation of Par-1b on serine 400 (S400), a residue that is conserved in all 4 mammalian Par-1 kinases as well as the fly ortholog.	Tetradecanoylphorbol Acetate	219-222	microtubule affinity regulating kinase 2	Homo sapiens	26-31
18638544-6	2008	The PKC activator phorbol 12-myristate 13-acetate could increase Nox activity in pulmonary and mesenteric arteries.	Tetradecanoylphorbol Acetate	18-49	protein kinase C, epsilon	Mus musculus	4-7
18755856-6	2008	Furthermore, phorbol 12-myristate 13-acetate , a PKC activator, induces the phosphorylation of endogenous FXR in HepG2 cells and PKCalpha phosphorylates in vitro FXR in its DNA-binding domain on S135 and S154.	Tetradecanoylphorbol Acetate	13-44	nuclear receptor subfamily 1 group H member 4	Homo sapiens	106-109
18755856-6	2008	Furthermore, phorbol 12-myristate 13-acetate , a PKC activator, induces the phosphorylation of endogenous FXR in HepG2 cells and PKCalpha phosphorylates in vitro FXR in its DNA-binding domain on S135 and S154.	Tetradecanoylphorbol Acetate	13-44	nuclear receptor subfamily 1 group H member 4	Homo sapiens	162-165
18800802-3	2008	TPA was topically applied to the shaven backs of ICR mice with or without CS (1 or 2 mg) for 4 h. The results demonstrated that CS suppressed TPA-induced edema and reduced the expression of cyclooxygenase-2, vascular cell adhesion molecule-1, and Akt signaling in mouse skin.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	190-206
18799680-4	2008	In dorsal root ganglia (DRG) neurons of Nox1(+/Y), pretreatment with chemical mediators bradykinin, serotonin, or phorbol 12-myristate 13-acetate (PMA) augmented the capsaicin-induced calcium increase, whereas this increase was significantly attenuated in DRG neurons of Nox1(-/Y).	Tetradecanoylphorbol Acetate	114-145	NADPH oxidase 1	Mus musculus	40-44
18799680-4	2008	In dorsal root ganglia (DRG) neurons of Nox1(+/Y), pretreatment with chemical mediators bradykinin, serotonin, or phorbol 12-myristate 13-acetate (PMA) augmented the capsaicin-induced calcium increase, whereas this increase was significantly attenuated in DRG neurons of Nox1(-/Y).	Tetradecanoylphorbol Acetate	114-145	NADPH oxidase 1	Mus musculus	271-279
18799680-4	2008	In dorsal root ganglia (DRG) neurons of Nox1(+/Y), pretreatment with chemical mediators bradykinin, serotonin, or phorbol 12-myristate 13-acetate (PMA) augmented the capsaicin-induced calcium increase, whereas this increase was significantly attenuated in DRG neurons of Nox1(-/Y).	Tetradecanoylphorbol Acetate	147-150	NADPH oxidase 1	Mus musculus	271-279
18799680-5	2008	Concomitantly, PMA-induced translocation of PKCepsilon was markedly perturbed in Nox1(-/Y) or Nox1(+/Y) DRG neurons treated with ROS-scavenging agents.	Tetradecanoylphorbol Acetate	15-18	protein kinase C, epsilon	Mus musculus	44-54
18799680-5	2008	Concomitantly, PMA-induced translocation of PKCepsilon was markedly perturbed in Nox1(-/Y) or Nox1(+/Y) DRG neurons treated with ROS-scavenging agents.	Tetradecanoylphorbol Acetate	15-18	NADPH oxidase 1	Mus musculus	81-85
18799680-5	2008	Concomitantly, PMA-induced translocation of PKCepsilon was markedly perturbed in Nox1(-/Y) or Nox1(+/Y) DRG neurons treated with ROS-scavenging agents.	Tetradecanoylphorbol Acetate	15-18	NADPH oxidase 1	Mus musculus	94-98
18713832-7	2008	AMPA plus PMA induced a decrease in surface GluR2 for more than 2 hours.	Tetradecanoylphorbol Acetate	10-13	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	44-49
18713832-9	2008	Furthermore, PMA plus arachidonic acid caused the prolonged internalization of GluR2 without activating AMPA receptors.	Tetradecanoylphorbol Acetate	13-16	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	79-84
18628248-4	2008	Application of QUE significantly suppressed TPA-induced activation of the PKCdelta/ERK/AP-1-signaling cascade.	Tetradecanoylphorbol Acetate	44-47	protein kinase C delta	Homo sapiens	74-82
18550790-1	2008	In resident mouse peritoneal macrophages, group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) mediates arachidonic acid (AA) release and eicosanoid production in response to diverse agonists such as A23187, phorbol myristate acetate, zymosan, and the enterotoxin, okadaic acid (OA).	Tetradecanoylphorbol Acetate	209-234	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	82-94
18690222-5	2008	Mice doubly deficient in MSK1 and MSK2 were hypersensitive to lipopolysaccharide-induced endotoxic shock and showed prolonged inflammation in a model of toxic contact eczema induced by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	185-216	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	25-29
18048355-4	2008	Here, we show that Kidins220, which is a substrate of PKD proteins in neuroendocrine cells, is localized in the ends of the processes of BON cells, similar to the expression pattern of NT vesicles, and translocates to the membrane and large vesicle-like structures formed in response to phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	287-318	kinase D interacting substrate 220	Homo sapiens	19-28
18048355-5	2008	The short hairpin RNA targeting Kidins220 inhibits NT secretion in parental BON cells or BON cells stably expressing the gastrin-releasing peptide receptor treated with either phorbol 12-myristate 13-acetate or bombesin, respectively.	Tetradecanoylphorbol Acetate	176-207	kinase D interacting substrate 220	Homo sapiens	32-41
17803461-5	2008	The beta2-chimaerin translocation from the cytoplasm to the plasma membrane caused by PMA plus H2O2 was further enhanced by the expression of DGKgamma.	Tetradecanoylphorbol Acetate	86-89	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	4-9
17803461-5	2008	The beta2-chimaerin translocation from the cytoplasm to the plasma membrane caused by PMA plus H2O2 was further enhanced by the expression of DGKgamma.	Tetradecanoylphorbol Acetate	86-89	diacylglycerol kinase gamma	Homo sapiens	142-150
18234971-1	2008	Cyclooxygenase-2 (COX-2) is reported to be one of the early-response gene products induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	132-135	prostaglandin-endoperoxide synthase 2	Mus musculus	0-16
18234971-1	2008	Cyclooxygenase-2 (COX-2) is reported to be one of the early-response gene products induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	132-135	prostaglandin-endoperoxide synthase 2	Mus musculus	18-23
18234971-2	2008	However, the relevance of COX-2 in TPA-induced cell transformation and the underlying mechanisms remains to be explored.	Tetradecanoylphorbol Acetate	35-38	prostaglandin-endoperoxide synthase 2	Mus musculus	26-31
18234971-3	2008	Initially, we verified COX-2 induction after TPA treatment in mouse embryonic fibroblasts (MEF) and mouse epidermal cells Cl 41.	Tetradecanoylphorbol Acetate	45-48	prostaglandin-endoperoxide synthase 2	Mus musculus	23-28
18234971-4	2008	More importantly, introduction of COX-2 small interfering RNA in MEFs or Cl 41 cells suppressed the cell transformation caused by TPA treatment.	Tetradecanoylphorbol Acetate	130-133	prostaglandin-endoperoxide synthase 2	Mus musculus	34-39
18234971-5	2008	This inhibition could be reversed by overexpression of human full-length COX-2, indicating that COX-2 is at least one of the critical molecules involved in TPA-induced cell transformation.	Tetradecanoylphorbol Acetate	156-159	prostaglandin-endoperoxide synthase 2	Mus musculus	73-78
18234971-5	2008	This inhibition could be reversed by overexpression of human full-length COX-2, indicating that COX-2 is at least one of the critical molecules involved in TPA-induced cell transformation.	Tetradecanoylphorbol Acetate	156-159	prostaglandin-endoperoxide synthase 2	Mus musculus	96-101
18234971-6	2008	We further showed that TPA-promoted cell cycle progression was partially suppressed by COX-2 small interfering RNA, indicating that COX-2 also participated in TPA-associated cell cycle progression.	Tetradecanoylphorbol Acetate	23-26	prostaglandin-endoperoxide synthase 2	Mus musculus	87-92
18234971-6	2008	We further showed that TPA-promoted cell cycle progression was partially suppressed by COX-2 small interfering RNA, indicating that COX-2 also participated in TPA-associated cell cycle progression.	Tetradecanoylphorbol Acetate	23-26	prostaglandin-endoperoxide synthase 2	Mus musculus	132-137
18234971-6	2008	We further showed that TPA-promoted cell cycle progression was partially suppressed by COX-2 small interfering RNA, indicating that COX-2 also participated in TPA-associated cell cycle progression.	Tetradecanoylphorbol Acetate	159-162	prostaglandin-endoperoxide synthase 2	Mus musculus	87-92
18234971-6	2008	We further showed that TPA-promoted cell cycle progression was partially suppressed by COX-2 small interfering RNA, indicating that COX-2 also participated in TPA-associated cell cycle progression.	Tetradecanoylphorbol Acetate	159-162	prostaglandin-endoperoxide synthase 2	Mus musculus	132-137
18234971-8	2008	Furthermore, inhibition of c-Jun/activator protein 1 pathway or JNKs/c-Jun pathway by overexpression of dominant negative mutants of c-Jun, or MKK4 and MKK7 together, resulted in impairment of COX-2 induction, suggesting that JNK1/c-Jun/activator protein 1 pathway is involved in TPA-associated COX-2 induction.	Tetradecanoylphorbol Acetate	280-283	prostaglandin-endoperoxide synthase 2	Mus musculus	193-198
18234971-11	2008	Our results show that JNK1-associated COX-2 induction is implicated in TPA-associated cell transformation and cell cycle progression.	Tetradecanoylphorbol Acetate	71-74	prostaglandin-endoperoxide synthase 2	Mus musculus	38-43
17880928-8	2007	Furthermore, Rh2 significantly repressed the PMA-mediated activation of p38 MAPK, ERK and JNK, which are upstream modulators of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	45-48	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	142-146
17962218-2	2007	Herein, we report the first investigation of the inhibitory effects of 5-OH-HxMF on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	122-125	prostaglandin-endoperoxide synthase 2	Mus musculus	210-215
17962218-3	2007	We found that the topical application of 5-OH-HxMF can effectively inhibit the transcriptional activation of iNOS and COX-2 mRNA and protein in mouse skin stimulated by TPA.	Tetradecanoylphorbol Acetate	169-172	prostaglandin-endoperoxide synthase 2	Mus musculus	118-123
17962218-6	2007	Moreover, 5-OH-HxMF can suppress TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt, which are upstream of NF-kappaB.	Tetradecanoylphorbol Acetate	33-36	mitogen-activated protein kinase 3	Mus musculus	59-100
17962218-6	2007	Moreover, 5-OH-HxMF can suppress TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt, which are upstream of NF-kappaB.	Tetradecanoylphorbol Acetate	33-36	mitogen-activated protein kinase 14	Mus musculus	102-105
18056199-7	2007	Although TPA enhances the TRAIL-receptor 1 (DR4) level, sensitization of prostate cancer cells seems to be more dependent on TRAIL-receptor 2 (DR5) than TRAIL-receptor 1 levels.	Tetradecanoylphorbol Acetate	9-12	TNF receptor superfamily member 10a	Homo sapiens	26-42
18056199-7	2007	Although TPA enhances the TRAIL-receptor 1 (DR4) level, sensitization of prostate cancer cells seems to be more dependent on TRAIL-receptor 2 (DR5) than TRAIL-receptor 1 levels.	Tetradecanoylphorbol Acetate	9-12	TNF receptor superfamily member 10a	Homo sapiens	44-47
18098040-1	2007	Our previous studies showed that protein kinase Cepsilon (PKCepsilon) verexpression in mouse skin resulted in metastatic squamous cell carcinoma (SCC) elicited by single 7,12-dimethylbenz(a)anthracene (DMBA)-initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promotion in the absence of preceding papilloma formation as is typically observed in wild type mice.	Tetradecanoylphorbol Acetate	223-259	protein kinase C, epsilon	Mus musculus	33-56
18098040-1	2007	Our previous studies showed that protein kinase Cepsilon (PKCepsilon) verexpression in mouse skin resulted in metastatic squamous cell carcinoma (SCC) elicited by single 7,12-dimethylbenz(a)anthracene (DMBA)-initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promotion in the absence of preceding papilloma formation as is typically observed in wild type mice.	Tetradecanoylphorbol Acetate	223-259	protein kinase C, epsilon	Mus musculus	58-68
18098040-1	2007	Our previous studies showed that protein kinase Cepsilon (PKCepsilon) verexpression in mouse skin resulted in metastatic squamous cell carcinoma (SCC) elicited by single 7,12-dimethylbenz(a)anthracene (DMBA)-initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promotion in the absence of preceding papilloma formation as is typically observed in wild type mice.	Tetradecanoylphorbol Acetate	261-264	protein kinase C, epsilon	Mus musculus	33-56
18098040-1	2007	Our previous studies showed that protein kinase Cepsilon (PKCepsilon) verexpression in mouse skin resulted in metastatic squamous cell carcinoma (SCC) elicited by single 7,12-dimethylbenz(a)anthracene (DMBA)-initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promotion in the absence of preceding papilloma formation as is typically observed in wild type mice.	Tetradecanoylphorbol Acetate	261-264	protein kinase C, epsilon	Mus musculus	58-68
17675337-1	2007	Previous studies have shown that keratin 6 (K6)-spermidine/spermine N1-acetyltransferase (SSAT) transgenic mice, which modestly over-express SSAT in the skin, are more sensitive to tumor induction by a two-stage tumorigenesis protocol using initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	314-350	spermidine/spermine N1-acetyl transferase 1	Mus musculus	90-94
17675337-1	2007	Previous studies have shown that keratin 6 (K6)-spermidine/spermine N1-acetyltransferase (SSAT) transgenic mice, which modestly over-express SSAT in the skin, are more sensitive to tumor induction by a two-stage tumorigenesis protocol using initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	352-355	spermidine/spermine N1-acetyl transferase 1	Mus musculus	90-94
17277233-4	2007	We found that EP2 knockout mice had reduced cyclooxygenase-2 (COX-2) expression after 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment compared with wild-type (WT) mice.	Tetradecanoylphorbol Acetate	86-122	prostaglandin-endoperoxide synthase 2	Mus musculus	62-67
17277233-4	2007	We found that EP2 knockout mice had reduced cyclooxygenase-2 (COX-2) expression after 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment compared with wild-type (WT) mice.	Tetradecanoylphorbol Acetate	124-127	prostaglandin-endoperoxide synthase 2	Mus musculus	62-67
17277233-5	2007	Further, primary keratinocytes from EP2 transgenic mice had increased COX-2 expression after either TPA or PGE2 treatment and COX-2 expression was blocked by 10 microM SQ 22,536, an adenylate cyclase inhibitor.	Tetradecanoylphorbol Acetate	100-103	prostaglandin-endoperoxide synthase 2	Mus musculus	70-75
17786281-3	2007	These effects were blocked by a tyrosine kinase inhibitor (PP2) or Src small interfering RNA (siRNA), indicating that Src was involved in the PMA-induced activation of Cas/Crk/Rac1 signaling pathway.	Tetradecanoylphorbol Acetate	142-145	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	59-62
17786281-8	2007	We demonstrated that PMA induced phosphorylation of Crk, and this phosphorylation was blocked by PP2 or Src siRNA.	Tetradecanoylphorbol Acetate	21-24	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	97-100
17616647-4	2007	nPKCdelta in SPOC1 cells was tyrosine phosphorylated by exposure to purinergic agonist (ATPgammaS) or PMA, actions that were blocked by the Src kinase inhibitor, PP1.	Tetradecanoylphorbol Acetate	102-105	protein kinase C, delta	Rattus norvegicus	0-9
17586481-4	2007	METHODS: RSK2 capacity to phosphorylate a synthetic CREB-peptide in basal and PMA-stimulated conditions was evaluated in lymphoblasts from 3 patients with RSK2 mutations and normal controls.	Tetradecanoylphorbol Acetate	78-81	ribosomal protein S6 kinase A3	Homo sapiens	9-13
17846509-4	2007	The suppression of mesenchymal cell proliferation induced by TGF-beta 3 and ADAM 10 morpholino antisense oligonucleotides was reversed by activation of ADAM 10 with phorbol 12-myristate 13-acetate (PMA) or knockdown of Notch-1 with siRNA.	Tetradecanoylphorbol Acetate	165-196	ADAM metallopeptidase domain 10	Gallus gallus	76-83
17846509-4	2007	The suppression of mesenchymal cell proliferation induced by TGF-beta 3 and ADAM 10 morpholino antisense oligonucleotides was reversed by activation of ADAM 10 with phorbol 12-myristate 13-acetate (PMA) or knockdown of Notch-1 with siRNA.	Tetradecanoylphorbol Acetate	165-196	ADAM metallopeptidase domain 10	Gallus gallus	152-159
17699780-11	2007	Overexpression of wild-type (WT) and S9A mutant GSK3beta in JB6 P+ cells suppressed EGF and TPA-mediated anchorage-independent growth in soft agar and tumorigenicity in nude mice.	Tetradecanoylphorbol Acetate	92-95	glycogen synthase kinase 3 beta	Homo sapiens	48-56
17636002-2	2007	We now show that Cl(-) intracellular channel 4 (CLIC4) expression is increased in both mouse and human keratinocytes undergoing differentiation induced by Ca(2+), serum and the protein kinase C (PKC)-activator, 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	211-248	protein kinase C delta	Homo sapiens	195-198
17636002-2	2007	We now show that Cl(-) intracellular channel 4 (CLIC4) expression is increased in both mouse and human keratinocytes undergoing differentiation induced by Ca(2+), serum and the protein kinase C (PKC)-activator, 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	250-253	protein kinase C delta	Homo sapiens	195-198
17553897-6	2007	In human TPA-differentiated HL-60 cells, which are macrophage-like cells, LPS-induced MOR mRNA up-regulation was greater in gp120-pretreated cells than in vehicle-pretreated cells.	Tetradecanoylphorbol Acetate	9-12	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	124-129
17507007-3	2007	Furthermore, FPP-3 reduced MMP-2 expression at protein and mRNA levels, and suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced expression of MT1-MMP without changing tissue inhibitors of metalloproteinase (TIMP)-2 level.	Tetradecanoylphorbol Acetate	87-123	matrix metallopeptidase 14	Homo sapiens	153-160
17507007-3	2007	Furthermore, FPP-3 reduced MMP-2 expression at protein and mRNA levels, and suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced expression of MT1-MMP without changing tissue inhibitors of metalloproteinase (TIMP)-2 level.	Tetradecanoylphorbol Acetate	125-128	matrix metallopeptidase 14	Homo sapiens	153-160
17234724-8	2007	Activation of AP-1 in skin was detected as early as 2 weeks following Cum-OOH or TPA exposure.	Tetradecanoylphorbol Acetate	81-84	jun proto-oncogene	Mus musculus	14-18
17638522-4	2007	Although tPA, another form of plasminogen activators (PAs), partially compensated the lose of PAs activities, uPA mRNA and protein were significantly reduced as demonstrated by real-time reverse transcription PCR and a chromogenic assay, after the treatment of Sertoli cells with uPA specific TFOs at a concentration of 330 nM.	Tetradecanoylphorbol Acetate	9-12	plasminogen activator, urokinase	Rattus norvegicus	280-283
17468105-0	2007	Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cells.	Tetradecanoylphorbol Acetate	78-114	lysine acetyltransferase 2B	Homo sapiens	26-30
17468105-0	2007	Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cells.	Tetradecanoylphorbol Acetate	78-114	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	35-39
17468105-0	2007	Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cells.	Tetradecanoylphorbol Acetate	78-114	myogenin	Homo sapiens	55-63
17468105-4	2007	By using quantitative real-time-based chromatin immunoprecipitation and real-time reverse transcription-PCR-based promoter activity assays, we examined the activation mechanism of the myogenin gene during TPA-induced differentiation of the RD cells.	Tetradecanoylphorbol Acetate	205-208	myogenin	Homo sapiens	184-192
17468105-7	2007	In addition, we have found that the p38 mitogen-activated protein kinase is required for BRG1 recruitment in TPA-mediated myogenin induction.	Tetradecanoylphorbol Acetate	109-112	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	89-93
17468105-7	2007	In addition, we have found that the p38 mitogen-activated protein kinase is required for BRG1 recruitment in TPA-mediated myogenin induction.	Tetradecanoylphorbol Acetate	109-112	myogenin	Homo sapiens	122-130
17468105-8	2007	We propose that there are two distinct activation steps for the induction of myogenin in TPA-induced early differentiation of RD cells: 1) an early step that requires PCAF activity to acetylate core histones and MyoD to initiate myogenin gene expression, and 2) a later step that requires p38-dependent activity of the SWI/SNF remodeling complex to provide an open conformation for the induction of myogenin.	Tetradecanoylphorbol Acetate	89-92	myogenin	Homo sapiens	77-85
17468105-8	2007	We propose that there are two distinct activation steps for the induction of myogenin in TPA-induced early differentiation of RD cells: 1) an early step that requires PCAF activity to acetylate core histones and MyoD to initiate myogenin gene expression, and 2) a later step that requires p38-dependent activity of the SWI/SNF remodeling complex to provide an open conformation for the induction of myogenin.	Tetradecanoylphorbol Acetate	89-92	lysine acetyltransferase 2B	Homo sapiens	167-171
17468105-8	2007	We propose that there are two distinct activation steps for the induction of myogenin in TPA-induced early differentiation of RD cells: 1) an early step that requires PCAF activity to acetylate core histones and MyoD to initiate myogenin gene expression, and 2) a later step that requires p38-dependent activity of the SWI/SNF remodeling complex to provide an open conformation for the induction of myogenin.	Tetradecanoylphorbol Acetate	89-92	myogenin	Homo sapiens	229-237
17468105-8	2007	We propose that there are two distinct activation steps for the induction of myogenin in TPA-induced early differentiation of RD cells: 1) an early step that requires PCAF activity to acetylate core histones and MyoD to initiate myogenin gene expression, and 2) a later step that requires p38-dependent activity of the SWI/SNF remodeling complex to provide an open conformation for the induction of myogenin.	Tetradecanoylphorbol Acetate	89-92	myogenin	Homo sapiens	229-237
17234720-0	2007	Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B.	Tetradecanoylphorbol Acetate	23-59	prostaglandin-endoperoxide synthase 2	Mus musculus	182-234
17234720-5	2007	To further elucidate the molecular mechanisms underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling molecules controlling these proteins were explored in mouse skin.	Tetradecanoylphorbol Acetate	126-129	prostaglandin-endoperoxide synthase 2	Mus musculus	201-206
17234720-6	2007	The pre-treatment with xanthorrhizol inhibited the expression of ODC, iNOS and COX-2 proteins and nuclear factor-kappaB (NF-kappaB) activation in both mouse skin with TPA-induced acute inflammation and DMBA-initiated mouse skin promoted by TPA for 19 weeks.	Tetradecanoylphorbol Acetate	167-170	prostaglandin-endoperoxide synthase 2	Mus musculus	79-84
18675280-6	2008	Furthermore, the expression of CYP2J2 mRNA increased when the human monocytic cell line THP-1 cells and human monocytes were stimulated with phorbol 12-myristate 13-acetate and macrophage-colony stimulating factor in combination with granulocyte/macrophage-colony stimulating factor, respectively.	Tetradecanoylphorbol Acetate	141-172	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	31-37
18690846-4	2008	The tumor promoter phorbol 12-myristate 13-acetate (PMA) enhanced the expression of 4Ig-hB7H3 in FEMX-I (melanoma), MA11 (breast cancer), and OHS (osteosarcoma) cells, suggesting that 4Ig-hB7H3 may be implicated in tumorigenesis.	Tetradecanoylphorbol Acetate	19-50	CD276 molecule	Homo sapiens	84-93
18477669-3	2008	In primary human nasal epithelial cells, treatment with TPA led not only to activation of phosphorylation of PKC, myristoylated alanine-rich C kinase substrate, and mitogen-activated protein kinase but also expression of novel PKC-delta, PKC-theta, and PKC-epsilon.	Tetradecanoylphorbol Acetate	56-59	myristoylated alanine rich protein kinase C substrate	Homo sapiens	114-159
18477669-3	2008	In primary human nasal epithelial cells, treatment with TPA led not only to activation of phosphorylation of PKC, myristoylated alanine-rich C kinase substrate, and mitogen-activated protein kinase but also expression of novel PKC-delta, PKC-theta, and PKC-epsilon.	Tetradecanoylphorbol Acetate	56-59	protein kinase C delta	Homo sapiens	227-236
18477669-4	2008	Treatment with TPA increased transepithelial electrical resistance, with tight junction barrier function more than 4-fold that of the control, together with up-regulation of tight junction proteins, occludin, zona occludens (ZO)-1, ZO-2 and claudin-1 at the transcriptional level.	Tetradecanoylphorbol Acetate	15-18	occludin	Homo sapiens	199-207
18477669-4	2008	Treatment with TPA increased transepithelial electrical resistance, with tight junction barrier function more than 4-fold that of the control, together with up-regulation of tight junction proteins, occludin, zona occludens (ZO)-1, ZO-2 and claudin-1 at the transcriptional level.	Tetradecanoylphorbol Acetate	15-18	tight junction protein 2	Homo sapiens	232-236
18477669-8	2008	The knockdown of GATA-3 using RNA interference resulted in inhibition of up-regulation of ZO-1 and ZO-2 by treatment with TPA.	Tetradecanoylphorbol Acetate	122-125	tight junction protein 2	Homo sapiens	99-103
18534633-8	2008	In addition, hemin suppressed the TPA-induced activation of extracellular signal-regulated protein kinase (ERK) and p38 MAPK in a dose-dependent manner.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase 14	Mus musculus	116-119
18534633-9	2008	Taken together, hemin inhibited TPA-induced COX-2 expression by altering NF-kappaB signaling pathway via ERK and p38 MAPK, as well as TPA-induced ODC expression in mouse skin.	Tetradecanoylphorbol Acetate	32-35	cytochrome c oxidase II, mitochondrial	Mus musculus	44-49
18534633-9	2008	Taken together, hemin inhibited TPA-induced COX-2 expression by altering NF-kappaB signaling pathway via ERK and p38 MAPK, as well as TPA-induced ODC expression in mouse skin.	Tetradecanoylphorbol Acetate	32-35	mitogen-activated protein kinase 14	Mus musculus	113-121
18331597-3	2008	We found that staphylokinase (SAK), a well-known Plg activator of bacterial origin, inhibits Plg activation mediated by endogenous tPA and uPA.	Tetradecanoylphorbol Acetate	131-134	plasminogen	Homo sapiens	49-52
18331597-3	2008	We found that staphylokinase (SAK), a well-known Plg activator of bacterial origin, inhibits Plg activation mediated by endogenous tPA and uPA.	Tetradecanoylphorbol Acetate	131-134	plasminogen	Homo sapiens	93-96
18331597-4	2008	Furthermore, mixture of SAK with tPA led to a significantly reduced Plg-dependent fibrinolysis.	Tetradecanoylphorbol Acetate	33-36	plasminogen	Homo sapiens	68-71
18331597-7	2008	Finally, we show that NH2-terminal residues of SAK are important for the inhibitory effect of SAK on tPA- and uPA-mediated Plg activation.	Tetradecanoylphorbol Acetate	101-104	plasminogen	Homo sapiens	123-126
18331597-8	2008	In conclusion, SAK reduces tPA/uPA-mediated Plg activation by means of SAK.Plg complex formation, consequently downregulating tPA/uPA-induced fibrinolysis.	Tetradecanoylphorbol Acetate	27-30	plasminogen	Homo sapiens	44-47
18331597-8	2008	In conclusion, SAK reduces tPA/uPA-mediated Plg activation by means of SAK.Plg complex formation, consequently downregulating tPA/uPA-induced fibrinolysis.	Tetradecanoylphorbol Acetate	27-30	plasminogen	Homo sapiens	75-78
18331597-8	2008	In conclusion, SAK reduces tPA/uPA-mediated Plg activation by means of SAK.Plg complex formation, consequently downregulating tPA/uPA-induced fibrinolysis.	Tetradecanoylphorbol Acetate	126-129	plasminogen	Homo sapiens	44-47
18331597-8	2008	In conclusion, SAK reduces tPA/uPA-mediated Plg activation by means of SAK.Plg complex formation, consequently downregulating tPA/uPA-induced fibrinolysis.	Tetradecanoylphorbol Acetate	126-129	plasminogen	Homo sapiens	75-78
18491380-9	2008	The protein synthesis inhibitor cycloheximide completely inhibited upregulation of HGF mRNA induced by maleic acid but superinduced HGF mRNA expression upregulated by 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	167-203	hepatocyte growth factor	Homo sapiens	132-135
16698017-2	2006	In this study, we examined the effects of five selected food phytochemicals on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced LOX-1 mRNA expression in THP-1 human monocyte-like cells.	Tetradecanoylphorbol Acetate	79-115	oxidized low density lipoprotein receptor 1	Homo sapiens	130-135
18645411-5	2008	AVP also activated extracellular signal-regulated kinase 1/2 (erk1/2), a response mimicked by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but abolished by depleting cellular PKC through chronic PMA incubation.	Tetradecanoylphorbol Acetate	128-159	mitogen activated protein kinase 3	Rattus norvegicus	19-60
18645411-5	2008	AVP also activated extracellular signal-regulated kinase 1/2 (erk1/2), a response mimicked by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but abolished by depleting cellular PKC through chronic PMA incubation.	Tetradecanoylphorbol Acetate	128-159	mitogen activated protein kinase 3	Rattus norvegicus	62-68
18645411-5	2008	AVP also activated extracellular signal-regulated kinase 1/2 (erk1/2), a response mimicked by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but abolished by depleting cellular PKC through chronic PMA incubation.	Tetradecanoylphorbol Acetate	161-164	mitogen activated protein kinase 3	Rattus norvegicus	19-60
18645411-5	2008	AVP also activated extracellular signal-regulated kinase 1/2 (erk1/2), a response mimicked by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but abolished by depleting cellular PKC through chronic PMA incubation.	Tetradecanoylphorbol Acetate	161-164	mitogen activated protein kinase 3	Rattus norvegicus	62-68
17570212-8	2007	No such differences were seen in peripheral blood, but stimulation with phorbol myristate acetate and ionomycin and, to a lesser extent, stimulation via NKG2D reduced the CCR9 expression on blood T cells.	Tetradecanoylphorbol Acetate	72-97	C-C motif chemokine receptor 9	Homo sapiens	171-175
16698017-2	2006	In this study, we examined the effects of five selected food phytochemicals on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced LOX-1 mRNA expression in THP-1 human monocyte-like cells.	Tetradecanoylphorbol Acetate	117-120	oxidized low density lipoprotein receptor 1	Homo sapiens	130-135
18425423-7	2008	Significant increase in the protein levels of c-jun, p65, and p53 by ELISA were observed in DMBA/TPA treated mice tumors whereas less expression was observed in LA and LAM treated tumors.	Tetradecanoylphorbol Acetate	97-100	jun proto-oncogene	Mus musculus	46-51
16380208-7	2006	Inhibitor of Ca2+-dependent PKC isozymes specifically abolished PMA-induced TRPM8 desensitization.	Tetradecanoylphorbol Acetate	64-67	transient receptor potential cation channel subfamily M member 8	Homo sapiens	76-81
19688047-6	2008	RESULTS: The pharmacological PKC activator phorbol-12-myristate-13-acetate (PMA) and platelet-derived growth factor (PDGF) were able to induce the activation of Raf-1 kinase in the v-H-ras-transformed NIH3T3 fibroblasts.	Tetradecanoylphorbol Acetate	43-74	protein kinase C, epsilon	Mus musculus	29-32
19688047-6	2008	RESULTS: The pharmacological PKC activator phorbol-12-myristate-13-acetate (PMA) and platelet-derived growth factor (PDGF) were able to induce the activation of Raf-1 kinase in the v-H-ras-transformed NIH3T3 fibroblasts.	Tetradecanoylphorbol Acetate	76-79	protein kinase C, epsilon	Mus musculus	29-32
17449225-5	2007	Furthermore, phorbol 12-myristate 13-acetate (PMA) or ionomycin alone could efficiently induce BTLA protein expression on CD4+ and CD8+ T cells, while CsA significantly suppressed BTLA expression in this system.	Tetradecanoylphorbol Acetate	13-44	B and T lymphocyte associated	Mus musculus	95-99
17449225-5	2007	Furthermore, phorbol 12-myristate 13-acetate (PMA) or ionomycin alone could efficiently induce BTLA protein expression on CD4+ and CD8+ T cells, while CsA significantly suppressed BTLA expression in this system.	Tetradecanoylphorbol Acetate	46-49	B and T lymphocyte associated	Mus musculus	95-99
17449225-5	2007	Furthermore, phorbol 12-myristate 13-acetate (PMA) or ionomycin alone could efficiently induce BTLA protein expression on CD4+ and CD8+ T cells, while CsA significantly suppressed BTLA expression in this system.	Tetradecanoylphorbol Acetate	46-49	B and T lymphocyte associated	Mus musculus	180-184
16565508-3	2006	Here, we report the cloning of a novel cDNA sequence, from mouse back skin, that is induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and codes for a hitherto unknown aspartic proteinase-like protein (Taps).	Tetradecanoylphorbol Acetate	151-154	aspartic peptidase, retroviral-like 1	Mus musculus	223-227
17448503-2	2007	The protein level of nucleophosmin/B23 (NPM/B23), a nucleolar protein, was substantially decreased upon TPA treatment.	Tetradecanoylphorbol Acetate	104-107	nucleophosmin 1	Homo sapiens	40-47
17448503-3	2007	In this study, we found that the proteasome inhibitors blocked the decrease of NPM/B23 protein in response to TPA, suggesting the proteasomes were involved in the downregulation of NPM/B23 upon megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	110-113	nucleophosmin 1	Homo sapiens	79-86
18483269-7	2008	Overexpression of wild-type PKD3 in LNCaP cells blocked phorbol 12-myristate 13-acetate (PMA)-induced apoptosis in association with inhibition of PMA-induced down-regulation of Akt activity, and prolonged extracellular signal-regulated kinase (ERK)1/2 activation.	Tetradecanoylphorbol Acetate	56-87	protein kinase D3	Homo sapiens	28-32
18483269-7	2008	Overexpression of wild-type PKD3 in LNCaP cells blocked phorbol 12-myristate 13-acetate (PMA)-induced apoptosis in association with inhibition of PMA-induced down-regulation of Akt activity, and prolonged extracellular signal-regulated kinase (ERK)1/2 activation.	Tetradecanoylphorbol Acetate	89-92	protein kinase D3	Homo sapiens	28-32
17448503-3	2007	In this study, we found that the proteasome inhibitors blocked the decrease of NPM/B23 protein in response to TPA, suggesting the proteasomes were involved in the downregulation of NPM/B23 upon megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	110-113	nucleophosmin 1	Homo sapiens	79-82
16361709-3	2006	We examined the regulation of PKCdelta in cardiac myocytes by endothelin-1 (Gq protein-coupled receptor agonist) and platelet-derived growth factor (receptor tyrosine kinase agonist) in comparison with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	235-238	protein kinase C delta	Homo sapiens	30-38
17448503-4	2007	To investigate the signaling pathway in the downregulation of NPM/B23 during early TPA-induced megakaryocytic differentiation of K562 cells, K562 cells were treated with TPA in the presence of the PKC isozyme-selective inhibitors, GF109203X and Go 6976, or MEK1 inhibitor, PD98059.	Tetradecanoylphorbol Acetate	83-86	nucleophosmin 1	Homo sapiens	62-69
17448503-4	2007	To investigate the signaling pathway in the downregulation of NPM/B23 during early TPA-induced megakaryocytic differentiation of K562 cells, K562 cells were treated with TPA in the presence of the PKC isozyme-selective inhibitors, GF109203X and Go 6976, or MEK1 inhibitor, PD98059.	Tetradecanoylphorbol Acetate	170-173	nucleophosmin 1	Homo sapiens	62-69
17448503-5	2007	The decrease of NPM/B23 protein in the TPA-treated K562 cells was blocked by GF109203X but not by Go 6976, suggesting the involvement of novel PKCs in the downregulation of NPM/B23 during TPA-induced megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	39-42	nucleophosmin 1	Homo sapiens	16-23
17448503-5	2007	The decrease of NPM/B23 protein in the TPA-treated K562 cells was blocked by GF109203X but not by Go 6976, suggesting the involvement of novel PKCs in the downregulation of NPM/B23 during TPA-induced megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	39-42	nucleophosmin 1	Homo sapiens	16-19
17448503-5	2007	The decrease of NPM/B23 protein in the TPA-treated K562 cells was blocked by GF109203X but not by Go 6976, suggesting the involvement of novel PKCs in the downregulation of NPM/B23 during TPA-induced megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	188-191	nucleophosmin 1	Homo sapiens	16-23
17448503-5	2007	The decrease of NPM/B23 protein in the TPA-treated K562 cells was blocked by GF109203X but not by Go 6976, suggesting the involvement of novel PKCs in the downregulation of NPM/B23 during TPA-induced megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	188-191	nucleophosmin 1	Homo sapiens	16-19
18594782-3	2008	RESULTS: Activation of endothelial protein kinase C (PKC) by either phorbol myristate acetate (PMA) or bryostatin-1 (a potent PKC delta and epsilon activator) completely abolished neutrophil migration mediated by either endothelial TNF-alpha stimulation or LTB4.	Tetradecanoylphorbol Acetate	68-93	protein kinase C delta	Homo sapiens	126-135
18594783-3	2008	MATERIALS AND METHODS: The expression of TTP in J774 macrophages was induced by a combination of LPS and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	105-130	ZFP36 ring finger protein	Homo sapiens	41-44
18594783-3	2008	MATERIALS AND METHODS: The expression of TTP in J774 macrophages was induced by a combination of LPS and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	132-135	ZFP36 ring finger protein	Homo sapiens	41-44
18594783-6	2008	RESULTS: cPKC inhibitors RO318220, GO6976, LY333531 and CGP53353 inhibited LPS and PMA-induced expression of TTP protein and mRNA.	Tetradecanoylphorbol Acetate	83-86	ZFP36 ring finger protein	Homo sapiens	109-112
17448503-6	2007	The application of MEK1 inhibitor PD98059 upon TPA treatment blocked the TPA-induced decrease of NPM/B23 protein and aborted the megakaryocytic differentiation but not to break through the cell growth arrest.	Tetradecanoylphorbol Acetate	47-50	nucleophosmin 1	Homo sapiens	97-104
17448503-6	2007	The application of MEK1 inhibitor PD98059 upon TPA treatment blocked the TPA-induced decrease of NPM/B23 protein and aborted the megakaryocytic differentiation but not to break through the cell growth arrest.	Tetradecanoylphorbol Acetate	73-76	nucleophosmin 1	Homo sapiens	97-104
17448503-7	2007	Unlike NPM/B23, the degradation of nucleolin in the TPA-treated K562 cells could not be blocked by PD98059 while the TPA-induced megakaryocytic differentiation was abrogated.	Tetradecanoylphorbol Acetate	52-55	nucleolin	Homo sapiens	35-44
18296509-7	2008	Microinjecting eggs with mutant-unphosphorylatable MARCKS reduced the intensity of 12-O-tetradecanoylphorbol 13-acetate or ionomycin-induced CGE by 50%, indicating that phosphorylation of MARCKS by novel and/or conventional PKCs (n/cPKCs) is a pivotal event associated with CGE.	Tetradecanoylphorbol Acetate	83-119	myristoylated alanine rich protein kinase C substrate	Homo sapiens	51-57
18296509-7	2008	Microinjecting eggs with mutant-unphosphorylatable MARCKS reduced the intensity of 12-O-tetradecanoylphorbol 13-acetate or ionomycin-induced CGE by 50%, indicating that phosphorylation of MARCKS by novel and/or conventional PKCs (n/cPKCs) is a pivotal event associated with CGE.	Tetradecanoylphorbol Acetate	83-119	myristoylated alanine rich protein kinase C substrate	Homo sapiens	188-194
16184549-2	2006	We have shown recently that PMA-induced death of C4-2 cells, androgen hypersensitive derivatives of LNCaP cells, requires both PKCdelta and a redundant pathway that includes PKCs alpha and epsilon.	Tetradecanoylphorbol Acetate	28-31	protein kinase C delta	Homo sapiens	127-135
16236821-3	2006	In the course of studies exploring PKC-delta phosphorylation mechanisms in cardiomyocytes, we have demonstrated that a BD Transduction Laboratories anti-PKC-delta MAb (generally viewed as an anti-PKC-delta protein antibody) recognizes PKC-delta in resting, but not in PMA-treated, cardiomyocytes.	Tetradecanoylphorbol Acetate	268-271	protein kinase C delta	Homo sapiens	35-44
18204848-6	2008	In the present study, we sought to determine whether the cytokine interleukin-1alpha (IL-1alpha) and its regulator transforming growth factor beta1 (TGF-beta1), which are both commonly present in skin wounds, influence tPA production in cultured murine epidermal keratinocytes.	Tetradecanoylphorbol Acetate	219-222	transforming growth factor, beta 1	Mus musculus	115-147
18204848-6	2008	In the present study, we sought to determine whether the cytokine interleukin-1alpha (IL-1alpha) and its regulator transforming growth factor beta1 (TGF-beta1), which are both commonly present in skin wounds, influence tPA production in cultured murine epidermal keratinocytes.	Tetradecanoylphorbol Acetate	219-222	transforming growth factor, beta 1	Mus musculus	149-158
18204848-10	2008	However, treatment of keratinocytes with TGF-beta1 partially inhibited IL-1alpha induced expression of tPA mRNA in dose dependent manners and the maximal inhibition was seen at 60 ng/ml.	Tetradecanoylphorbol Acetate	103-106	transforming growth factor, beta 1	Mus musculus	41-50
18204848-11	2008	Our findings could explain tPA generation in wound epidermis is at least partially controlled by changes in local IL-1alpha activity, and will contribute to our understanding the physiological effects of IL-1alpha and TGF-beta1 as well as their interaction of with the PA system during skin wound healing.	Tetradecanoylphorbol Acetate	27-30	transforming growth factor, beta 1	Mus musculus	218-227
17448503-9	2007	Taken together, our results indicated that novel PKC-MAPK pathway was required for the decrease of NPM/B23 during TPA-induced megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	114-117	nucleophosmin 1	Homo sapiens	99-106
17114644-0	2007	Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms.	Tetradecanoylphorbol Acetate	24-27	zinc fingers and homeoboxes 2	Homo sapiens	96-99
17114644-6	2007	In addition, ascofuranone suppressed PMA-induced phosphorylation of Ras, Raf, MEK and extracellular signal-regulated kinase (ERK), upstream factors involved in AP-1activation, whereas the phosphorylation of p38 and JNK/mitogen-activated protein kinase was not affected by ascofuranone, suggesting that the primary target of ascofuranone for suppression of the AP-1 induction is present in upstream of ERK signaling pathway.	Tetradecanoylphorbol Acetate	37-40	zinc fingers and homeoboxes 2	Homo sapiens	73-76
17386407-1	2007	In this study, we investigated the involvement of mast cells in the regulation of matrix metalloproteinase-9 (MMP-9) in 12-O-tetradecanoylphorbolacetate (TPA)-induced inflammation, using mast cell-deficient (W/W(v)) mice and control (+/+) mice.	Tetradecanoylphorbol Acetate	120-152	matrix metallopeptidase 9	Mus musculus	82-108
17386407-1	2007	In this study, we investigated the involvement of mast cells in the regulation of matrix metalloproteinase-9 (MMP-9) in 12-O-tetradecanoylphorbolacetate (TPA)-induced inflammation, using mast cell-deficient (W/W(v)) mice and control (+/+) mice.	Tetradecanoylphorbol Acetate	120-152	matrix metallopeptidase 9	Mus musculus	110-115
16542154-4	2006	In this study we succeeded in purifying human plasma ADA2 and demonstrate the extracellular secretion of ADA2 from human peripheral blood monocytes stimulated with phorbol 12-myristate 13-acetate and calcium ionophore.	Tetradecanoylphorbol Acetate	164-195	adenosine deaminase 2	Homo sapiens	105-109
17386407-1	2007	In this study, we investigated the involvement of mast cells in the regulation of matrix metalloproteinase-9 (MMP-9) in 12-O-tetradecanoylphorbolacetate (TPA)-induced inflammation, using mast cell-deficient (W/W(v)) mice and control (+/+) mice.	Tetradecanoylphorbol Acetate	154-157	matrix metallopeptidase 9	Mus musculus	82-108
17386407-1	2007	In this study, we investigated the involvement of mast cells in the regulation of matrix metalloproteinase-9 (MMP-9) in 12-O-tetradecanoylphorbolacetate (TPA)-induced inflammation, using mast cell-deficient (W/W(v)) mice and control (+/+) mice.	Tetradecanoylphorbol Acetate	154-157	matrix metallopeptidase 9	Mus musculus	110-115
17386407-2	2007	Topical application of TPA to the ears induced acute inflammation, accompanied by mast cell degranulation in +/+ mice, which peaked at 6-12 h. There was no significant difference in ear thickness between the groups until 12 h, but the swelling was greater in W/W(v) mice than +/+ mice at 24-36 h. Western blot analysis revealed that TPA-induced marked increases in levels of proMMP-9 and tissue inhibitor of metalloproteinases-1 (TIMP-1), which existed as complexes with proMMP-9.	Tetradecanoylphorbol Acetate	23-26	matrix metallopeptidase 9	Mus musculus	375-383
17386407-2	2007	Topical application of TPA to the ears induced acute inflammation, accompanied by mast cell degranulation in +/+ mice, which peaked at 6-12 h. There was no significant difference in ear thickness between the groups until 12 h, but the swelling was greater in W/W(v) mice than +/+ mice at 24-36 h. Western blot analysis revealed that TPA-induced marked increases in levels of proMMP-9 and tissue inhibitor of metalloproteinases-1 (TIMP-1), which existed as complexes with proMMP-9.	Tetradecanoylphorbol Acetate	23-26	matrix metallopeptidase 9	Mus musculus	471-479
17301838-0	2007	Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.	Tetradecanoylphorbol Acetate	33-36	retinoid X receptor alpha	Mus musculus	105-130
17207890-12	2007	Immunoblotting experiments showed that TPA was more potent than TNF-alpha to induce in a PKCalpha/beta dependent manner the p44/p42 mitogen-activated protein kinases (MAPK) signaling cascade which controls AP-1 activity.	Tetradecanoylphorbol Acetate	39-42	interferon induced protein 44	Homo sapiens	124-127
18381464-3	2008	Here, we report that MSK1 is involved in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced or epidermal growth factor (EGF)-induced neoplastic transformation of JB6 Cl41 cells.	Tetradecanoylphorbol Acetate	41-77	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	21-25
18381464-3	2008	Here, we report that MSK1 is involved in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced or epidermal growth factor (EGF)-induced neoplastic transformation of JB6 Cl41 cells.	Tetradecanoylphorbol Acetate	79-82	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	21-25
18381464-4	2008	H89, a potent inhibitor of MSK1, strongly suppressed TPA-induced or EGF-induced cell transformation.	Tetradecanoylphorbol Acetate	53-56	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	27-31
18381464-5	2008	When cells overexpressing wild-type MSK1 were treated with TPA or EGF, colony formation increased substantially compared with untreated cells or cells that did not overexpress MSK1.	Tetradecanoylphorbol Acetate	59-62	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	36-40
18381464-5	2008	When cells overexpressing wild-type MSK1 were treated with TPA or EGF, colony formation increased substantially compared with untreated cells or cells that did not overexpress MSK1.	Tetradecanoylphorbol Acetate	59-62	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	176-180
18381464-7	2008	Introduction of small interfering RNA-MSK1 into JB6 Cl41 cells resulted in suppressed TPA-induced or EGF-induced cell transformation.	Tetradecanoylphorbol Acetate	86-89	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	38-42
18381464-9	2008	In wild-type MSK1-overexpressing cells, activator protein (AP-1) activation increased after TPA or EGF stimulation, whereas AP-1 activation decreased in both MSK1 dominant-negative mutants and in MSK1 knockdown cells.	Tetradecanoylphorbol Acetate	92-95	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	13-17
18381464-10	2008	Moreover, TPA-induced or EGF-induced phosphorylation of histone H3 at Ser(10) was increased in wild-type cells but the induced phosphorylation was abolished in MSK1 dominant-negative mutant or MSK1 knockdown cells.	Tetradecanoylphorbol Acetate	10-13	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	160-164
18381464-10	2008	Moreover, TPA-induced or EGF-induced phosphorylation of histone H3 at Ser(10) was increased in wild-type cells but the induced phosphorylation was abolished in MSK1 dominant-negative mutant or MSK1 knockdown cells.	Tetradecanoylphorbol Acetate	10-13	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	193-197
18403643-6	2008	Reappearance of full-length cyclin E and CUX1 could be induced upon the treatment of MV4;11 cells with the differentiation inducer phorbol 12-myristate 13-acetate or, unexpectedly, following overexpression of a short recombinant CUX1 protein.	Tetradecanoylphorbol Acetate	131-162	cut like homeobox 1	Homo sapiens	41-45
17207890-12	2007	Immunoblotting experiments showed that TPA was more potent than TNF-alpha to induce in a PKCalpha/beta dependent manner the p44/p42 mitogen-activated protein kinases (MAPK) signaling cascade which controls AP-1 activity.	Tetradecanoylphorbol Acetate	39-42	proteasome 26S subunit, ATPase 6	Homo sapiens	128-131
16244358-9	2006	Interestingly, TPA potentiated BPDE-induced activation of ERKs whereas p38 MAPK activation was significantly inhibited by TPA, suggesting that inhibition of p38 MAPK is involved in p53 attenuation by TPA.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 14	Mus musculus	157-160
16244358-9	2006	Interestingly, TPA potentiated BPDE-induced activation of ERKs whereas p38 MAPK activation was significantly inhibited by TPA, suggesting that inhibition of p38 MAPK is involved in p53 attenuation by TPA.	Tetradecanoylphorbol Acetate	122-125	mitogen-activated protein kinase 14	Mus musculus	71-74
18328512-4	2008	CJH7-2 also potently inhibits COX-2 enzymatic activity (IC(50)=5 microg/mL) and TPA-induced COX-2 protein expression in mouse skin (1mg/200 microL/site).	Tetradecanoylphorbol Acetate	80-83	cytochrome c oxidase II, mitochondrial	Mus musculus	92-97
16244358-9	2006	Interestingly, TPA potentiated BPDE-induced activation of ERKs whereas p38 MAPK activation was significantly inhibited by TPA, suggesting that inhibition of p38 MAPK is involved in p53 attenuation by TPA.	Tetradecanoylphorbol Acetate	122-125	mitogen-activated protein kinase 14	Mus musculus	157-160
16244358-9	2006	Interestingly, TPA potentiated BPDE-induced activation of ERKs whereas p38 MAPK activation was significantly inhibited by TPA, suggesting that inhibition of p38 MAPK is involved in p53 attenuation by TPA.	Tetradecanoylphorbol Acetate	122-125	mitogen-activated protein kinase 14	Mus musculus	71-74
17510310-4	2007	Using RNA interference, we have reduced the expression of COX-2 in the highly malignant breast cancer cell line MDA-MB-231 below detectable levels in response to interleukin-1 beta or 12-O-tetradecanoylphorbol-13-acetate treatment.	Tetradecanoylphorbol Acetate	184-220	cytochrome c oxidase II, mitochondrial	Mus musculus	58-63
16244358-9	2006	Interestingly, TPA potentiated BPDE-induced activation of ERKs whereas p38 MAPK activation was significantly inhibited by TPA, suggesting that inhibition of p38 MAPK is involved in p53 attenuation by TPA.	Tetradecanoylphorbol Acetate	122-125	mitogen-activated protein kinase 14	Mus musculus	157-160
16510567-7	2006	Proteolytic shedding of both NKG2D ligands MICA and ULBP2 by tumor cells was strongly enhanced after phorbol 12-myristate 13-acetate treatment and paralleled by a markedly reduced susceptibility to NKG2D-mediated cytotoxicity.	Tetradecanoylphorbol Acetate	101-132	killer cell lectin like receptor K1	Homo sapiens	29-34
17440073-0	2007	SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation.	Tetradecanoylphorbol Acetate	97-133	ring finger protein 7	Mus musculus	9-13
17440073-0	2007	SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation.	Tetradecanoylphorbol Acetate	97-133	jun proto-oncogene	Mus musculus	25-44
17440073-0	2007	SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation.	Tetradecanoylphorbol Acetate	97-133	jun proto-oncogene	Mus musculus	66-71
17440073-7	2007	TPA-mediated SAG induction was significantly reduced in JB6-Cl.41 cells overexpressing a dominant-negative c-Jun, indicating a requirement of c-Jun/AP-1.	Tetradecanoylphorbol Acetate	0-3	jun proto-oncogene	Mus musculus	107-112
17942973-10	2008	Furthermore, stimulation of the endogenous NF45-NF90 complex in Jurkat cells by phorbol myristate acetate + ionomycin up-regulated the SP-10 promoter activity in plasmid-based assays.	Tetradecanoylphorbol Acetate	80-105	interleukin enhancer binding factor 2	Homo sapiens	43-52
17942973-10	2008	Furthermore, stimulation of the endogenous NF45-NF90 complex in Jurkat cells by phorbol myristate acetate + ionomycin up-regulated the SP-10 promoter activity in plasmid-based assays.	Tetradecanoylphorbol Acetate	80-105	acrosomal vesicle protein 1	Homo sapiens	135-140
18070609-5	2008	Functional studies with Gal4-p65 constructs revealed that serine 276 is crucial to confer LPS-dependent repression of TPA-mediated induction of p65 transactivation.	Tetradecanoylphorbol Acetate	118-121	RELA proto-oncogene, NF-kB subunit	Homo sapiens	29-32
18070609-5	2008	Functional studies with Gal4-p65 constructs revealed that serine 276 is crucial to confer LPS-dependent repression of TPA-mediated induction of p65 transactivation.	Tetradecanoylphorbol Acetate	118-121	RELA proto-oncogene, NF-kB subunit	Homo sapiens	144-147
18070609-7	2008	In summary, LPS-dependent inhibition of Prx I gene activation by TPA in monocytes is regulated via a pathway that involves phosphorylation of the NF-kappaB subunit p65 at serine 276.	Tetradecanoylphorbol Acetate	65-68	RELA proto-oncogene, NF-kB subunit	Homo sapiens	164-167
17440073-7	2007	TPA-mediated SAG induction was significantly reduced in JB6-Cl.41 cells overexpressing a dominant-negative c-Jun, indicating a requirement of c-Jun/AP-1.	Tetradecanoylphorbol Acetate	0-3	jun proto-oncogene	Mus musculus	142-147
17440073-7	2007	TPA-mediated SAG induction was significantly reduced in JB6-Cl.41 cells overexpressing a dominant-negative c-Jun, indicating a requirement of c-Jun/AP-1.	Tetradecanoylphorbol Acetate	0-3	jun proto-oncogene	Mus musculus	148-152
16510567-7	2006	Proteolytic shedding of both NKG2D ligands MICA and ULBP2 by tumor cells was strongly enhanced after phorbol 12-myristate 13-acetate treatment and paralleled by a markedly reduced susceptibility to NKG2D-mediated cytotoxicity.	Tetradecanoylphorbol Acetate	101-132	MHC class I polypeptide-related sequence A	Homo sapiens	43-47
17440073-9	2007	When overexpressed, SAG remarkably reduced both basal and TPA-induced c-Jun levels, whereas SAG small interfering RNA (siRNA) silencing increased substantially the levels of both basal and TPA-induced c-Jun.	Tetradecanoylphorbol Acetate	58-61	jun proto-oncogene	Mus musculus	70-75
17440073-9	2007	When overexpressed, SAG remarkably reduced both basal and TPA-induced c-Jun levels, whereas SAG small interfering RNA (siRNA) silencing increased substantially the levels of both basal and TPA-induced c-Jun.	Tetradecanoylphorbol Acetate	189-192	jun proto-oncogene	Mus musculus	201-206
18024961-2	2008	An RasGRP4-defective variant of the human MC line HMC-1 was used to create stable clones expressing green fluorescent protein-labeled RasGRP4 for monitoring the movement of this protein inside MCs after exposure to phorbol 12-myristate 13-acetate (PMA), and for evaluating the protein"s ability to control gene expression.	Tetradecanoylphorbol Acetate	215-246	RAS guanyl releasing protein 4	Homo sapiens	3-10
18257749-2	2008	2 Inhibitors of this kinase (PP2 and Src Inhibitor II) decreased ( approximately 50-75%) noradrenaline- (NA) and phorbol myristate acetate-mediated receptor phosphorylation.	Tetradecanoylphorbol Acetate	113-138	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	29-32
18234971-0	2008	A JNK1/AP-1-dependent, COX-2 induction is implicated in 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation through regulating cell cycle progression.	Tetradecanoylphorbol Acetate	56-92	jun proto-oncogene	Mus musculus	7-11
18234971-0	2008	A JNK1/AP-1-dependent, COX-2 induction is implicated in 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation through regulating cell cycle progression.	Tetradecanoylphorbol Acetate	56-92	prostaglandin-endoperoxide synthase 2	Mus musculus	23-28
16601289-6	2006	In addition, the activation of ERK1/2 by GnRH-I or II was mimicked by phorbol-12-myristate 13-acetate, a PKC activator.	Tetradecanoylphorbol Acetate	70-101	gonadotropin releasing hormone 1	Homo sapiens	41-45
18234971-1	2008	Cyclooxygenase-2 (COX-2) is reported to be one of the early-response gene products induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	94-130	prostaglandin-endoperoxide synthase 2	Mus musculus	0-16
18234971-1	2008	Cyclooxygenase-2 (COX-2) is reported to be one of the early-response gene products induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	94-130	prostaglandin-endoperoxide synthase 2	Mus musculus	18-23
16553792-5	2006	Prior administration of PD98059 also antagonized the enhancing effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator that also causes ERK activation, on SGK phosphorylation and cAMP response element binding protein (CREB) phosphorylation.	Tetradecanoylphorbol Acetate	73-109	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	182-185
18199973-9	2007	PMA treatment in the subconjunctival fibroblasts elicited phosphorylation of SAPKs, including c-jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAPK).	Tetradecanoylphorbol Acetate	0-3	mitogen activated protein kinase 14	Rattus norvegicus	128-131
17962218-2	2007	Herein, we report the first investigation of the inhibitory effects of 5-OH-HxMF on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	84-120	prostaglandin-endoperoxide synthase 2	Mus musculus	192-208
17962218-2	2007	Herein, we report the first investigation of the inhibitory effects of 5-OH-HxMF on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	84-120	prostaglandin-endoperoxide synthase 2	Mus musculus	210-215
17350626-7	2007	Both the IL-6 synthesis and the phosphorylation of p44/p42 MAP kinase stimulated by 12-O-tetradecanoylphorbol 13-acetate (TPA), a direct activator of PKC, were markedly suppressed by EGCG.	Tetradecanoylphorbol Acetate	84-120	mitogen-activated protein kinase 3	Mus musculus	51-54
17350626-7	2007	Both the IL-6 synthesis and the phosphorylation of p44/p42 MAP kinase stimulated by 12-O-tetradecanoylphorbol 13-acetate (TPA), a direct activator of PKC, were markedly suppressed by EGCG.	Tetradecanoylphorbol Acetate	84-120	cyclin-dependent kinase 20	Mus musculus	55-58
17350626-7	2007	Both the IL-6 synthesis and the phosphorylation of p44/p42 MAP kinase stimulated by 12-O-tetradecanoylphorbol 13-acetate (TPA), a direct activator of PKC, were markedly suppressed by EGCG.	Tetradecanoylphorbol Acetate	122-125	mitogen-activated protein kinase 3	Mus musculus	51-54
17350626-7	2007	Both the IL-6 synthesis and the phosphorylation of p44/p42 MAP kinase stimulated by 12-O-tetradecanoylphorbol 13-acetate (TPA), a direct activator of PKC, were markedly suppressed by EGCG.	Tetradecanoylphorbol Acetate	122-125	cyclin-dependent kinase 20	Mus musculus	55-58
17350626-8	2007	The phosphorylation of MEK1/2 and Raf-1 induced by ET-1 or TPA were also inhibited by EGCG.	Tetradecanoylphorbol Acetate	59-62	mitogen-activated protein kinase kinase 1	Mus musculus	23-29
17962218-2	2007	Herein, we report the first investigation of the inhibitory effects of 5-OH-HxMF on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse skin.	Tetradecanoylphorbol Acetate	122-125	prostaglandin-endoperoxide synthase 2	Mus musculus	192-208
16553792-5	2006	Prior administration of PD98059 also antagonized the enhancing effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator that also causes ERK activation, on SGK phosphorylation and cAMP response element binding protein (CREB) phosphorylation.	Tetradecanoylphorbol Acetate	111-114	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	182-185
16553792-6	2006	Moreover, TPA-induced SGK phosphorylation and CREB phosphorylation was abolished by prior SGKS78A mutant DNA transfection.	Tetradecanoylphorbol Acetate	10-13	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	22-25
16698439-7	2006	T lymphocytes present in PBMCs and isolated CD4+ T lymphocytes stimulated with phorbol-12-myristate-13-acetate and ionomycin also induced MICA expression as assessed by Western blot, but only low levels were expressed at the cell surface.	Tetradecanoylphorbol Acetate	79-110	MHC class I polypeptide-related sequence A	Homo sapiens	138-142
17919561-9	2007	PMA-stimulated MAPK activity was completely inhibited by the EGF receptor inhibitor AG1478 (10(-7)M).	Tetradecanoylphorbol Acetate	0-3	mitogen activated protein kinase 3	Rattus norvegicus	15-19
17119118-4	2007	In accordance with this, activated neutrophils coreleased ARG1 and gelatinase to the extracellular environment on stimulation with phorbol-12-myristate 13-acetate (PMA), formyl-methionyl-leucyl-phenylalanine (fMLP), or tumor necrosis factor alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	131-162	arginase 1	Homo sapiens	58-62
17119118-4	2007	In accordance with this, activated neutrophils coreleased ARG1 and gelatinase to the extracellular environment on stimulation with phorbol-12-myristate 13-acetate (PMA), formyl-methionyl-leucyl-phenylalanine (fMLP), or tumor necrosis factor alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	164-167	arginase 1	Homo sapiens	58-62
16476973-7	2006	Some of the important genes that were overexpressed during the S phase of the cell cycle compared with the G0/1 phase of TPA-induced BCBL-1 cells are v-myb myeloblastosis (MYBL2), protein kinase-membrane associated tyrosine/threonine 1 (PKMYT1), ribonucleotide reductase M1 polypeptide (RRM1) and peroxisome proliferator-activated receptors delta (PPARD).	Tetradecanoylphorbol Acetate	121-124	ribonucleotide reductase catalytic subunit M1	Homo sapiens	246-285
17420607-2	2007	In the present study, we used differentiated Caco-2 cells as a model of the human small intestine to evaluate the suppressive effects of 16 traditional food items selected from Okinawa on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced LOX-1 mRNA expression in THP-1 human monocyte-like cells.	Tetradecanoylphorbol Acetate	188-224	oxidized low density lipoprotein receptor 1	Homo sapiens	239-244
17895316-9	2007	TPA also led to complete inhibition of CYP17.	Tetradecanoylphorbol Acetate	0-3	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	39-44
17583568-4	2007	62: 2516, 2002) that these mice, referred to as keratin 14 (K14).COX2 mice, were unexpectedly very resistant to 12-O-tetradecanoylphorbol 13-acetate (TPA) tumor promotion.	Tetradecanoylphorbol Acetate	112-148	cytochrome c oxidase II, mitochondrial	Mus musculus	65-69
16476973-7	2006	Some of the important genes that were overexpressed during the S phase of the cell cycle compared with the G0/1 phase of TPA-induced BCBL-1 cells are v-myb myeloblastosis (MYBL2), protein kinase-membrane associated tyrosine/threonine 1 (PKMYT1), ribonucleotide reductase M1 polypeptide (RRM1) and peroxisome proliferator-activated receptors delta (PPARD).	Tetradecanoylphorbol Acetate	121-124	ribonucleotide reductase catalytic subunit M1	Homo sapiens	287-291
16528250-5	2006	High glucose, angiotensin II, phorbol 12-myristate 13-acetate and transforming growth factor-beta 1 (TGF-beta1) stimulated OPN mRNA expression in IRPTCs in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	30-61	secreted phosphoprotein 1	Rattus norvegicus	123-126
17692050-7	2007	The cell growth rate decreased and exposure to PMA induced peculiar morphological changes in cells expressing S910A, with respect to wild-type FAK, suggesting a role for Ser910 in these processes.	Tetradecanoylphorbol Acetate	47-50	protein tyrosine kinase 2	Homo sapiens	143-146
16293641-5	2006	The E2-induced recruitment of c-Fos to a 12-O-tetradecanoylphorbol-13-acetate response element site in the PR promoter was significantly reduced in the presence of ERbeta, whereas only a slight reduction in the recruitment of c-Fos to the pS2 promoter was observed.	Tetradecanoylphorbol Acetate	41-77	progesterone receptor	Homo sapiens	107-109
17724030-4	2007	Here we report that equol inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic transformation of JB6 P+ mouse epidermal cells by targeting the MEK/ERK/p90RSK/activator protein-1 signaling pathway.	Tetradecanoylphorbol Acetate	35-71	midkine	Mus musculus	161-164
17724030-4	2007	Here we report that equol inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic transformation of JB6 P+ mouse epidermal cells by targeting the MEK/ERK/p90RSK/activator protein-1 signaling pathway.	Tetradecanoylphorbol Acetate	35-71	Eph receptor B2	Mus musculus	165-168
17071627-0	2007	Methylseleninic acid inhibits PMA-stimulated pro-MMP-2 activation mediated by MT1-MMP expression and further tumor invasion through suppression of NF-kappaB activation.	Tetradecanoylphorbol Acetate	30-33	matrix metallopeptidase 2	Homo sapiens	49-54
17071627-0	2007	Methylseleninic acid inhibits PMA-stimulated pro-MMP-2 activation mediated by MT1-MMP expression and further tumor invasion through suppression of NF-kappaB activation.	Tetradecanoylphorbol Acetate	30-33	matrix metallopeptidase 14	Homo sapiens	78-85
17071627-4	2007	In this study, we demonstrate that MSeA suppresses pro-MMP-2 activation in a dose-dependent manner induced by 12-O-tetradecanoylphorbol-13-acetate (PMA), and further decreases the invasiveness of HT1080 tumor cells.	Tetradecanoylphorbol Acetate	110-146	matrix metallopeptidase 2	Homo sapiens	55-60
17724030-4	2007	Here we report that equol inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic transformation of JB6 P+ mouse epidermal cells by targeting the MEK/ERK/p90RSK/activator protein-1 signaling pathway.	Tetradecanoylphorbol Acetate	73-76	midkine	Mus musculus	161-164
17724030-4	2007	Here we report that equol inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic transformation of JB6 P+ mouse epidermal cells by targeting the MEK/ERK/p90RSK/activator protein-1 signaling pathway.	Tetradecanoylphorbol Acetate	73-76	Eph receptor B2	Mus musculus	165-168
16293641-5	2006	The E2-induced recruitment of c-Fos to a 12-O-tetradecanoylphorbol-13-acetate response element site in the PR promoter was significantly reduced in the presence of ERbeta, whereas only a slight reduction in the recruitment of c-Fos to the pS2 promoter was observed.	Tetradecanoylphorbol Acetate	41-77	estrogen receptor 2	Homo sapiens	164-170
17284251-4	2007	While by the treatment with a tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), GFP-SUMO-1 located homogeneously in nuclei.	Tetradecanoylphorbol Acetate	45-81	small ubiquitin like modifier 1	Homo sapiens	93-99
16525579-4	2006	The rabbit myxoma viral serpin, Serp-1 inhibits urokinase- and tissue-type plasminogen activators (uPA and tPA), plasmin and factor Xa in vitro and exhibits remarkable anti-inflammatory activity in various animal models.	Tetradecanoylphorbol Acetate	107-110	stress-associated endoplasmic reticulum protein 1	Oryctolagus cuniculus	32-38
17284251-5	2007	When K562/GFP-SUMO-1 cells were treated with TPA plus MIT, GFP-SUMO-1 foci became larger and apoptosis was induced more than with MIT alone.	Tetradecanoylphorbol Acetate	45-48	small ubiquitin like modifier 1	Homo sapiens	14-20
17284251-5	2007	When K562/GFP-SUMO-1 cells were treated with TPA plus MIT, GFP-SUMO-1 foci became larger and apoptosis was induced more than with MIT alone.	Tetradecanoylphorbol Acetate	45-48	small ubiquitin like modifier 1	Homo sapiens	63-69
17284251-6	2007	The apoptosis induced by TPA plus MIT was prevented by blockage of GFP-SUMO-1 foci by small interfering RNA (siRNA) against SUMO-1.	Tetradecanoylphorbol Acetate	25-28	small ubiquitin like modifier 1	Homo sapiens	71-77
17284251-6	2007	The apoptosis induced by TPA plus MIT was prevented by blockage of GFP-SUMO-1 foci by small interfering RNA (siRNA) against SUMO-1.	Tetradecanoylphorbol Acetate	25-28	small ubiquitin like modifier 1	Homo sapiens	124-130
17670745-5	2007	Chromatin immunoprecipitation assays indicated that BAD is localized at the 12-O-tetradecanoylphorbol-13-acetate-response element (TRE) and cAMP-response element (CRE) in the cyclin D1 promoter.	Tetradecanoylphorbol Acetate	76-112	cyclin D1	Homo sapiens	175-184
16478713-3	2006	Under improved selection conditions using a TPA-responsive element (TRE) as a bait DNA, known interactors c-fos and c-jun were simultaneously enriched about 100-fold from a model library (a 1:1:20 000 mixture of c-fos, c-jun and gst genes) after one round of selection.	Tetradecanoylphorbol Acetate	44-47	jun proto-oncogene	Mus musculus	116-121
17635916-5	2007	Upon stimulation of HeLa cells by tumor promoter phorbol 12-myristate 13-acetate, a serine residue in a novel and putative nuclear export signal, identified for the first time, in SPHK2 was phosphorylated followed by SPHK2 export from the nucleus.	Tetradecanoylphorbol Acetate	49-80	sphingosine kinase 2	Homo sapiens	180-185
17635916-5	2007	Upon stimulation of HeLa cells by tumor promoter phorbol 12-myristate 13-acetate, a serine residue in a novel and putative nuclear export signal, identified for the first time, in SPHK2 was phosphorylated followed by SPHK2 export from the nucleus.	Tetradecanoylphorbol Acetate	49-80	sphingosine kinase 2	Homo sapiens	217-222
17635916-7	2007	Moreover, down-regulation of PKDs through RNA interference resulted in the attenuation of both basal and phorbol 12-myristate 13-acetate-induced phosphorylation, which was followed by the accumulation of SPHK2 in the nucleus in a manner rescued by PKD over-expression.	Tetradecanoylphorbol Acetate	105-136	sphingosine kinase 2	Homo sapiens	204-209
17400803-6	2007	Inhibition of ERK1/2 activity by U0126 decreased PMA-treated StAR expression but increased dbcAMP/hCG-mediated StAR and P-StAR; however, progesterone levels were attenuated.	Tetradecanoylphorbol Acetate	49-52	mitogen-activated protein kinase 3	Mus musculus	14-20
16452183-6	2006	On comparison with all previous HK1.ras carcinomas, such TPA-induced carcinomas expressed atypical retention of keratin K1 and lack of K13, a unique marker profile exhibited by TPA-induced K14.cre/PTEN(flx/flx) papillomas that also lacked endogenous c-ras(Ha) activation.	Tetradecanoylphorbol Acetate	57-60	keratin 13	Mus musculus	135-138
17453942-7	2007	Pretreatment with 10 and 100 ng/ml TPA decreased GJIC by 80% as compared to controls and increased Cx43 phosphorylation as assessed by immunoblotting.	Tetradecanoylphorbol Acetate	35-38	gap junction protein alpha 1	Canis lupus familiaris	99-103
17453942-8	2007	Pretreatment of cells with GF109203X and Go6976, partially restored TPA-inhibited GJIC by 40% and 60%, respectively, and reduced C x 43 phosphorylation.	Tetradecanoylphorbol Acetate	68-71	gap junction protein alpha 1	Canis lupus familiaris	129-135
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	62-93	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	142-160
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	62-93	keratin 16	Homo sapiens	162-172
16950795-3	2007	Topical application of 9Z,11E-CLA caused significant inhibition of COX-2 expression at 6 h induced by 10 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) in HR-1 mouse skin.	Tetradecanoylphorbol Acetate	110-146	prostaglandin-endoperoxide synthase 2	Mus musculus	67-72
17846172-3	2007	After AP-1 inactivation, epidermal proliferation induced by 7,12-dimethylbenz(a)-anthracene/12-O-tetradecanoylphorbol-13-acetate at the early stage of carcinogenesis was substantially inhibited.	Tetradecanoylphorbol Acetate	92-128	jun proto-oncogene	Mus musculus	6-10
18062235-5	2007	ODC activity induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) was inhibited by 33% and 39% with 3 and 4 mg/ml of COS, respectively.	Tetradecanoylphorbol Acetate	24-60	ornithine decarboxylase 1	Homo sapiens	0-3
18062235-5	2007	ODC activity induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) was inhibited by 33% and 39% with 3 and 4 mg/ml of COS, respectively.	Tetradecanoylphorbol Acetate	62-65	ornithine decarboxylase 1	Homo sapiens	0-3
15899518-6	2006	The physiological process of B cell activation induced by (1) either the cross-linking of the B cell receptor (BCR) or CD40, (2) treatment with LPS, or PMA plus ionomycin, induces TNFalpha mRNA splicing in vitro.	Tetradecanoylphorbol Acetate	152-155	CD40 antigen	Mus musculus	119-123
17538947-4	2007	It was further shown the Raf/Mek/Erk branch of mitogen-activated protein (MAP) kinase pathway contains a disproportionate number of oppositely regulated genes, thereby implicating it as one of the key pathways involved in tumor promotion by TPA, that is blocked by ATRA.	Tetradecanoylphorbol Acetate	241-244	midkine	Mus musculus	29-32
17583567-3	2007	PKC is a major intracellular receptor for 12-O-tetradecanoylphorbol-13-acetate (TPA) and is also activated by a variety of stress factors including ultraviolet radiation (UVR).	Tetradecanoylphorbol Acetate	42-78	protein kinase C, epsilon	Mus musculus	0-3
17583567-3	2007	PKC is a major intracellular receptor for 12-O-tetradecanoylphorbol-13-acetate (TPA) and is also activated by a variety of stress factors including ultraviolet radiation (UVR).	Tetradecanoylphorbol Acetate	80-83	protein kinase C, epsilon	Mus musculus	0-3
17583567-6	2007	PKCepsilon overexpressing transgenic mice, when treated either with TPA or exposed to UVR, elicit similar responses such as inhibition of apoptosis, promotion of cell survival, and development of SCC.	Tetradecanoylphorbol Acetate	68-71	protein kinase C, epsilon	Mus musculus	0-10
17583567-7	2007	PKCepsilon overexpression increases Stat3 activation after either TPA treatment or UVR exposure.	Tetradecanoylphorbol Acetate	66-69	protein kinase C, epsilon	Mus musculus	0-10
16950795-3	2007	Topical application of 9Z,11E-CLA caused significant inhibition of COX-2 expression at 6 h induced by 10 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) in HR-1 mouse skin.	Tetradecanoylphorbol Acetate	148-151	prostaglandin-endoperoxide synthase 2	Mus musculus	67-72
16950795-4	2007	Since NF-kappaB is known to regulate COX-2 gene expression, we determined the effect of 9Z,11E-CLA on TPA-induced activation of this transcription factor.	Tetradecanoylphorbol Acetate	102-105	prostaglandin-endoperoxide synthase 2	Mus musculus	37-42
16950795-6	2007	In addition, 9Z,11E-CLA attenuated TPA-induced phosphorylation of extracellular signal-regulated protein kinase, p38 mitogen-activated protein kinase and Akt.	Tetradecanoylphorbol Acetate	35-38	mitogen-activated protein kinase 14	Mus musculus	113-116
16950795-9	2007	Co-treatment of mouse skin with the IKKbeta-specific inhibitor SC-514 (1 micromol) attenuated TPA-induced activation of Akt and NF-kappaB, and also the expression of COX-2 in hairless mouse skin.	Tetradecanoylphorbol Acetate	94-97	prostaglandin-endoperoxide synthase 2	Mus musculus	166-171
16950795-10	2007	Taken together, 9Z,11E-CLA inhibits NF-kappaB driven-COX-2 expression by blocking the IKK and PI3K-Akt signaling in TPA-treated hairless mouse skin in vivo, which may account for its previously reported anti-tumor promoting effects.	Tetradecanoylphorbol Acetate	116-119	prostaglandin-endoperoxide synthase 2	Mus musculus	53-58
17673262-3	2007	12-O-tetradecanoylphorbol-13-acetate (TPA) and 1-oleoyl-2-acetylglycerol, direct activators of protein kinase C (PKC), markedly strengthened the phosphorylation of HSP27.	Tetradecanoylphorbol Acetate	38-41	protein kinase C delta	Homo sapiens	113-116
17673262-4	2007	Bisindorylmaleimide I, an inhibitor of PKC, suppressed the TPA-induced levels of HSP27 phosphorylation in addition to its basal levels.	Tetradecanoylphorbol Acetate	59-62	protein kinase C delta	Homo sapiens	39-42
16380122-9	2006	Hirsutenone blocked the TPA-induced DNA binding of nuclear factor kappa B (NF-kappaB) and translocation of p65, the functionally active NF-kappaB subunit, to the nucleus.	Tetradecanoylphorbol Acetate	24-27	RELA proto-oncogene, NF-kB subunit	Homo sapiens	107-110
16052516-6	2006	Pretreatment with the PKCdelta-selective inhibitor rottlerin or transfection with PKCdelta siRNA inhibited PMA-induced FLIP expression, which identifies a role for PKCdelta in FLIP induction.	Tetradecanoylphorbol Acetate	107-110	protein kinase C delta	Homo sapiens	22-30
17372274-4	2007	Topical application of humulone (10 mumol) significantly inhibited TPA-induced epidermal COX-2 expression.	Tetradecanoylphorbol Acetate	67-70	prostaglandin-endoperoxide synthase 2	Mus musculus	89-94
17372274-5	2007	Humulone also diminished TPA-induced DNA binding of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1).	Tetradecanoylphorbol Acetate	25-28	jun proto-oncogene	Mus musculus	90-109
17372274-5	2007	Humulone also diminished TPA-induced DNA binding of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1).	Tetradecanoylphorbol Acetate	25-28	jun proto-oncogene	Mus musculus	111-115
17228877-4	2007	In addition, the compound inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity with human bladder carcinoma cells (T24 cells), and TPA-induced nuclear factor-kappa B (NF-kappaB) activity with human hepatocellular liver carcinoma cells (HepG2 cells).	Tetradecanoylphorbol Acetate	35-71	ornithine decarboxylase 1	Homo sapiens	86-109
17228877-4	2007	In addition, the compound inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity with human bladder carcinoma cells (T24 cells), and TPA-induced nuclear factor-kappa B (NF-kappaB) activity with human hepatocellular liver carcinoma cells (HepG2 cells).	Tetradecanoylphorbol Acetate	35-71	ornithine decarboxylase 1	Homo sapiens	111-114
17228877-4	2007	In addition, the compound inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity with human bladder carcinoma cells (T24 cells), and TPA-induced nuclear factor-kappa B (NF-kappaB) activity with human hepatocellular liver carcinoma cells (HepG2 cells).	Tetradecanoylphorbol Acetate	73-76	ornithine decarboxylase 1	Homo sapiens	86-109
17228877-4	2007	In addition, the compound inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity with human bladder carcinoma cells (T24 cells), and TPA-induced nuclear factor-kappa B (NF-kappaB) activity with human hepatocellular liver carcinoma cells (HepG2 cells).	Tetradecanoylphorbol Acetate	73-76	ornithine decarboxylase 1	Homo sapiens	111-114
17228877-4	2007	In addition, the compound inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity with human bladder carcinoma cells (T24 cells), and TPA-induced nuclear factor-kappa B (NF-kappaB) activity with human hepatocellular liver carcinoma cells (HepG2 cells).	Tetradecanoylphorbol Acetate	177-180	ornithine decarboxylase 1	Homo sapiens	111-114
16951133-6	2007	Finally, in contrast to the massive effects of high doses of PMA (300 nM) on mucin secretion from goblet cells, phorbol ester stimulated a small (27.1 +/- 7% of the ATPgammaS control peak), brief rise in Ca(i)(2+).	Tetradecanoylphorbol Acetate	61-64	LOC100508689	Homo sapiens	77-82
17404063-3	2007	Our previous study revealed that EGCG inhibited expression of COX-2 and activation of mitogen-activated protein kinases (MAPKs) in mouse skin stimulated with a prototype tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	185-221	prostaglandin-endoperoxide synthase 2	Mus musculus	62-67
17404063-8	2007	Pretreatment with U0126 and SB203580, pharmacological inhibitors of ERK and p38 MAPK, respectively, showed that SB203580, but not U0126, attenuated TPA-induced CREB DNA binding in mouse skin.	Tetradecanoylphorbol Acetate	148-151	mitogen-activated protein kinase 14	Mus musculus	76-84
17404063-9	2007	Taken together, EGCG inhibited TPA-induced DNA binding of NF-kappaB and CREB by blocking activation of p38 MAPK, which may provide a molecular basis of COX-2 inhibition by EGCG in mouse skin in vivo.	Tetradecanoylphorbol Acetate	31-34	mitogen-activated protein kinase 14	Mus musculus	103-111
17404063-9	2007	Taken together, EGCG inhibited TPA-induced DNA binding of NF-kappaB and CREB by blocking activation of p38 MAPK, which may provide a molecular basis of COX-2 inhibition by EGCG in mouse skin in vivo.	Tetradecanoylphorbol Acetate	31-34	prostaglandin-endoperoxide synthase 2	Mus musculus	152-157
17541281-7	2007	Pharmacologically, IL-9 production was induced by ionomycin (IOM) alone, and enhanced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	89-120	interleukin 9	Homo sapiens	19-23
17541281-7	2007	Pharmacologically, IL-9 production was induced by ionomycin (IOM) alone, and enhanced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	122-125	interleukin 9	Homo sapiens	19-23
16979371-7	2007	Truncated H2A proteins in THP-1 cells were transiently increased in amount by short-term treatment with phorbol 12-myristate 13-acetate or all-trans-retinoic acid, both of which induce macrophage-like differentiation.	Tetradecanoylphorbol Acetate	104-135	H2A clustered histone 18	Homo sapiens	10-13
17848742-8	2007	Zymography demonstrated secretion of MMP-2 by untreated human testis cancer cells and MMP-9 with PMA induction.	Tetradecanoylphorbol Acetate	97-100	matrix metallopeptidase 2	Homo sapiens	37-42
17143503-0	2007	Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-gamma and 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	133-169	prostaglandin-endoperoxide synthase 2	Mus musculus	53-69
17097050-3	2006	Inhibition of AMPK by compound C, a specific inhibitor of AMPK or small interfering RNA of AMPKalpha1 suppressed IL-2 production in Jurkat T cells and peripheral blood lymphocytes stimulated with PMA plus ionomycin (PMA/Io) or with monoclonal anti-CD3 plus anti-CD28.	Tetradecanoylphorbol Acetate	196-199	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	14-18
17097050-3	2006	Inhibition of AMPK by compound C, a specific inhibitor of AMPK or small interfering RNA of AMPKalpha1 suppressed IL-2 production in Jurkat T cells and peripheral blood lymphocytes stimulated with PMA plus ionomycin (PMA/Io) or with monoclonal anti-CD3 plus anti-CD28.	Tetradecanoylphorbol Acetate	196-199	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	91-101
17097050-3	2006	Inhibition of AMPK by compound C, a specific inhibitor of AMPK or small interfering RNA of AMPKalpha1 suppressed IL-2 production in Jurkat T cells and peripheral blood lymphocytes stimulated with PMA plus ionomycin (PMA/Io) or with monoclonal anti-CD3 plus anti-CD28.	Tetradecanoylphorbol Acetate	216-219	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	14-18
17097050-3	2006	Inhibition of AMPK by compound C, a specific inhibitor of AMPK or small interfering RNA of AMPKalpha1 suppressed IL-2 production in Jurkat T cells and peripheral blood lymphocytes stimulated with PMA plus ionomycin (PMA/Io) or with monoclonal anti-CD3 plus anti-CD28.	Tetradecanoylphorbol Acetate	216-219	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	91-101
17097050-4	2006	We then showed that AMPK inhibition reduced PMA/Io-induced IL-2 mRNA expression and IL-2 promoter activation.	Tetradecanoylphorbol Acetate	44-47	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	20-24
17199943-12	2006	But eosinophils cultured with PMA + MA, IFN-gamma, IL-5 or GM-CSF expressed CD69 strongly.	Tetradecanoylphorbol Acetate	30-33	CD69 antigen	Mus musculus	76-80
16956982-7	2006	Agonist (oxytocin) or phorbol 12-myristate 13-acetate-induced activation of PKC led to phosphorylation of both CRH-R1 variants.	Tetradecanoylphorbol Acetate	22-53	corticotropin releasing hormone receptor 1	Homo sapiens	111-117
17116247-11	2006	Eight of the 14 recurrences early detected with CEA-TPA-CA15.3 presented as a single lesion (oligometastatic disease) (5) or were confined to bony skeleton (3) (26% and 16% respectively of the 19 relapses).	Tetradecanoylphorbol Acetate	52-55	mucin 1, cell surface associated	Homo sapiens	56-62
17116247-14	2006	Overall, CEA-TPA-CA15.3 panel is more accurate than MCA-CA15.3 association and can "early" detect a few relapsed patients with limited metastatic disease and more favourable prognosis.	Tetradecanoylphorbol Acetate	13-16	mucin 1, cell surface associated	Homo sapiens	17-23
17108111-3	2006	In this study, we explore how the status of p53 affects the immediate response gene activating transcription factor 3 (ATF3) in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-protein kinase C (PKC) pathway.	Tetradecanoylphorbol Acetate	132-168	transcription factor 3	Homo sapiens	95-117
17108111-3	2006	In this study, we explore how the status of p53 affects the immediate response gene activating transcription factor 3 (ATF3) in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-protein kinase C (PKC) pathway.	Tetradecanoylphorbol Acetate	170-173	transcription factor 3	Homo sapiens	95-117
17108111-6	2006	Mutagenesis analysis of the ATF3 promoter identified the regulatory motifs cyclic AMP-responsive element binding protein/ATF and MEF2 as being responsible for the TPA-induced activation of ATF3.	Tetradecanoylphorbol Acetate	163-166	myocyte enhancer factor 2A	Homo sapiens	129-133
17106266-5	2006	We now present the evidence that induction of oxidative stress in human peripheral blood leukocytes by phorbol myristate acetate (PMA) was associated with intense phosphorylation of histone H2AX and with ATM activation, seen already 60 min after exposure to PMA.	Tetradecanoylphorbol Acetate	103-128	H2A.X variant histone	Homo sapiens	190-194
17106266-5	2006	We now present the evidence that induction of oxidative stress in human peripheral blood leukocytes by phorbol myristate acetate (PMA) was associated with intense phosphorylation of histone H2AX and with ATM activation, seen already 60 min after exposure to PMA.	Tetradecanoylphorbol Acetate	130-133	H2A.X variant histone	Homo sapiens	190-194
16949178-7	2006	PMA treatment of HDMECs on a fibrin matrix stimulated MT1-MMP synthesis, indicating that this protease is involved in PMA-induced angiogenesis.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 14	Homo sapiens	54-61
17056501-1	2006	Increased levels of macrophage migration inhibitory factor (MIF) in serum, sputum, and bronchioalveolar lavage fluid (BALF) from asthmatic patients and time/dose-dependent expression of MIF in eosinophils in response to phorbol myristate acetate suggest the participation of MIF in airway inflammation.	Tetradecanoylphorbol Acetate	220-245	macrophage migration inhibitory factor	Homo sapiens	20-58
17056501-1	2006	Increased levels of macrophage migration inhibitory factor (MIF) in serum, sputum, and bronchioalveolar lavage fluid (BALF) from asthmatic patients and time/dose-dependent expression of MIF in eosinophils in response to phorbol myristate acetate suggest the participation of MIF in airway inflammation.	Tetradecanoylphorbol Acetate	220-245	macrophage migration inhibitory factor	Homo sapiens	186-189
17056501-1	2006	Increased levels of macrophage migration inhibitory factor (MIF) in serum, sputum, and bronchioalveolar lavage fluid (BALF) from asthmatic patients and time/dose-dependent expression of MIF in eosinophils in response to phorbol myristate acetate suggest the participation of MIF in airway inflammation.	Tetradecanoylphorbol Acetate	220-245	macrophage migration inhibitory factor	Homo sapiens	186-189
17034213-8	2006	The organic light-emitting diodes (OLEDs) with OXD and TPA showed green emission with electroluminescence (EL) quantum efficiencies of eta(EL) approximately 10(-2)%, while very weak EL efficiency of eta(EL) approximately 10(-5)% was observed with PYR.	Tetradecanoylphorbol Acetate	55-58	endothelin receptor type A	Homo sapiens	135-138
17034213-8	2006	The organic light-emitting diodes (OLEDs) with OXD and TPA showed green emission with electroluminescence (EL) quantum efficiencies of eta(EL) approximately 10(-2)%, while very weak EL efficiency of eta(EL) approximately 10(-5)% was observed with PYR.	Tetradecanoylphorbol Acetate	55-58	endothelin receptor type A	Homo sapiens	199-202
17015678-4	2006	Our results indicate that expression of TIM-2 significantly impairs the induction of NFAT and AP-1 transcriptional reporters by not only TCR ligation but also by the pharmacological stimuli PMA and ionomycin.	Tetradecanoylphorbol Acetate	190-193	T cell immunoglobulin and mucin domain containing 2	Mus musculus	40-45
16844724-8	2006	LPS and phorbol 12-myristate 13-acetate suppressed MMP-9 secretion in transitional cells, whereas LPS and concanavalin A stimulated MMP-9 secretion in mature B cells.	Tetradecanoylphorbol Acetate	8-39	matrix metallopeptidase 9	Mus musculus	51-56
16705353-11	2006	When HUVEC were stimulated with phorbol 12-myristate 13-acetate (PMA) secretion of pro MMP-2 was not increased, but the activation of pro MMP-2 into lower molecular forms increased, irrespective of culturing in LG, HG or CML-BSA.	Tetradecanoylphorbol Acetate	32-63	matrix metallopeptidase 2	Homo sapiens	87-92
16705353-11	2006	When HUVEC were stimulated with phorbol 12-myristate 13-acetate (PMA) secretion of pro MMP-2 was not increased, but the activation of pro MMP-2 into lower molecular forms increased, irrespective of culturing in LG, HG or CML-BSA.	Tetradecanoylphorbol Acetate	65-68	matrix metallopeptidase 2	Homo sapiens	87-92
18489265-5	2006	Melanocytes treated with phorbol 12-myristate 13-acetate (PMA) express TrkA and TrkB, but not TrkC.	Tetradecanoylphorbol Acetate	25-56	neurotrophic receptor tyrosine kinase 1	Homo sapiens	71-75
18489265-5	2006	Melanocytes treated with phorbol 12-myristate 13-acetate (PMA) express TrkA and TrkB, but not TrkC.	Tetradecanoylphorbol Acetate	25-56	neurotrophic receptor tyrosine kinase 2	Homo sapiens	80-84
18489265-5	2006	Melanocytes treated with phorbol 12-myristate 13-acetate (PMA) express TrkA and TrkB, but not TrkC.	Tetradecanoylphorbol Acetate	58-61	neurotrophic receptor tyrosine kinase 1	Homo sapiens	71-75
18489265-5	2006	Melanocytes treated with phorbol 12-myristate 13-acetate (PMA) express TrkA and TrkB, but not TrkC.	Tetradecanoylphorbol Acetate	58-61	neurotrophic receptor tyrosine kinase 2	Homo sapiens	80-84
16720572-7	2006	Activation of PKCepsilon by phorbol 12-myristate 13-acetate or H(2)O(2) resulted in mitoK(ATP)-independent inhibition of MPT opening, whereas activation of PKCepsilon by PKG or the specific PKCepsilon agonist psiepsilon receptor for activated C kinase caused mitoK(ATP)-dependent inhibition of MPT opening.	Tetradecanoylphorbol Acetate	28-59	ATPase phospholipid transporting 8A2	Homo sapiens	84-94
17372274-10	2007	The roles of extracellular signal-regulated protein kinase-1/2 and p38 MAPK in TPA-induced activation of NF-kappaB in mouse skin had been defined in our previous studies.	Tetradecanoylphorbol Acetate	79-82	mitogen-activated protein kinase 14	Mus musculus	67-75
17372274-11	2007	The present study revealed that topical application of SP600125, a pharmacological inhibitor of c-Jun-N-terminal kinase (JNK), abrogated the activation of AP-1 and the expression of COX-2 in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	191-194	jun proto-oncogene	Mus musculus	155-159
17372274-11	2007	The present study revealed that topical application of SP600125, a pharmacological inhibitor of c-Jun-N-terminal kinase (JNK), abrogated the activation of AP-1 and the expression of COX-2 in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	191-194	prostaglandin-endoperoxide synthase 2	Mus musculus	182-187
17372274-12	2007	Taken together, humulone suppressed TPA-induced activation of NF-kappaB and AP-1 and subsequent expression of COX-2 by blocking upstream kinases IKK and JNK, respectively, which may account for its antitumor-promoting effects on mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	36-39	jun proto-oncogene	Mus musculus	76-80
17372274-12	2007	Taken together, humulone suppressed TPA-induced activation of NF-kappaB and AP-1 and subsequent expression of COX-2 by blocking upstream kinases IKK and JNK, respectively, which may account for its antitumor-promoting effects on mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	36-39	prostaglandin-endoperoxide synthase 2	Mus musculus	110-115
17822058-9	2007	In this clone, the FRT-neo*-IRES-tPA gene was integrated at a transcription-active, DHFR-mediated, gene-amplifiable locus in the chromosomes.	Tetradecanoylphorbol Acetate	33-36	dihydrofolate reductase	Cricetulus griseus	84-88
17395152-5	2007	Short period activation of protein kinase C (PKC) by phorbol 12-myristate, 13-acetate (PMA) and alpha-adrenergic receptor agonist, phenylephrine (PE), downregulated sodium-dependent succinate transport presumably via hNaDC-3.	Tetradecanoylphorbol Acetate	87-90	solute carrier family 13 member 3	Homo sapiens	217-224
17395152-6	2007	The inhibition by PMA was partially prevented by cytochalasin D, suggesting that PKC reduces the hNaDC-3 activity, at least in part, by increased endocytosis.	Tetradecanoylphorbol Acetate	18-21	solute carrier family 13 member 3	Homo sapiens	97-104
17355247-10	2007	Moreover, leptin enhanced the expression of CD69 and CD25 on CD4(+) and CD8(+) cells after stimulation with PMA-ionomycin.	Tetradecanoylphorbol Acetate	108-111	CD69 molecule	Homo sapiens	44-48
17355247-10	2007	Moreover, leptin enhanced the expression of CD69 and CD25 on CD4(+) and CD8(+) cells after stimulation with PMA-ionomycin.	Tetradecanoylphorbol Acetate	108-111	interleukin 2 receptor subunit alpha	Homo sapiens	53-57
17452290-6	2007	Interestingly, the PMA-induced CREB phosphorylation was also blocked by a calcium/calmodulin-dependent protein kinase inhibitor KN93 and the two mitogen-activated protein kinase (MAPK) kinase inhibitors PD98059 and U0126, but not by a p38 MAPK inhibitor SB203580.	Tetradecanoylphorbol Acetate	19-22	mitogen activated protein kinase 3	Rattus norvegicus	179-183
17624242-12	2007	Phorbol-12-myristate-13-acetate (PMA), an activator of PKCs, rapidly increased ERK1/2 activation.	Tetradecanoylphorbol Acetate	0-31	mitogen activated protein kinase 3	Rattus norvegicus	79-85
17624242-12	2007	Phorbol-12-myristate-13-acetate (PMA), an activator of PKCs, rapidly increased ERK1/2 activation.	Tetradecanoylphorbol Acetate	33-36	mitogen activated protein kinase 3	Rattus norvegicus	79-85
17227770-2	2007	Exposure of untransfected C5N keratinocytes and transfected HEK293 cells to phorbol esters (12-O-tetradecanoylphorbol-13-acetate (TPA)) increased PED/PEA-15 cellular content and enhanced its phosphorylation at serine 116 in a time-dependent fashion.	Tetradecanoylphorbol Acetate	92-128	OCA2 melanosomal transmembrane protein	Homo sapiens	146-149
17227770-2	2007	Exposure of untransfected C5N keratinocytes and transfected HEK293 cells to phorbol esters (12-O-tetradecanoylphorbol-13-acetate (TPA)) increased PED/PEA-15 cellular content and enhanced its phosphorylation at serine 116 in a time-dependent fashion.	Tetradecanoylphorbol Acetate	130-133	OCA2 melanosomal transmembrane protein	Homo sapiens	146-149
17227757-19	2007	The potential biological relevance of the hBVR activation of PKC betaII was suggested by the finding that in cells transfected with the PKC betaII, hBVR augmented phorbol myristate acetate-mediated c-fos expression, and infection with sihBVR attenuated the response.	Tetradecanoylphorbol Acetate	163-188	biliverdin reductase A	Homo sapiens	42-46
17227757-19	2007	The potential biological relevance of the hBVR activation of PKC betaII was suggested by the finding that in cells transfected with the PKC betaII, hBVR augmented phorbol myristate acetate-mediated c-fos expression, and infection with sihBVR attenuated the response.	Tetradecanoylphorbol Acetate	163-188	biliverdin reductase A	Homo sapiens	148-152
17227757-20	2007	Also, in cells overexpressing hBVR and PKC betaII, as well as in untransfected cells, upon treatment with phorbol myristate acetate, the PKC translocated to the plasma membrane and co-localized with hBVR.	Tetradecanoylphorbol Acetate	106-131	biliverdin reductase A	Homo sapiens	30-34
17227757-20	2007	Also, in cells overexpressing hBVR and PKC betaII, as well as in untransfected cells, upon treatment with phorbol myristate acetate, the PKC translocated to the plasma membrane and co-localized with hBVR.	Tetradecanoylphorbol Acetate	106-131	biliverdin reductase A	Homo sapiens	199-203
17188004-2	2007	In the present study, we investigated the pH-dependence of phorbol myristate acetate (PMA)-induced PMN spreading.	Tetradecanoylphorbol Acetate	59-84	glucose-6-phosphate isomerase	Homo sapiens	42-44
17188004-2	2007	In the present study, we investigated the pH-dependence of phorbol myristate acetate (PMA)-induced PMN spreading.	Tetradecanoylphorbol Acetate	86-89	glucose-6-phosphate isomerase	Homo sapiens	42-44
17276885-11	2007	Furthermore, tyrosine kinase inhibitor, tyrphostin, inhibited the histamine mediated phosphorylation of STAT6 when stimulated with PMA+ionomycin.	Tetradecanoylphorbol Acetate	131-134	signal transducer and activator of transcription 6	Mus musculus	104-109
17464217-0	2007	PMA activates Stat3 in the Jak/Stat pathway and induces SOCS5 in rat brain astrocytes.	Tetradecanoylphorbol Acetate	0-3	suppressor of cytokine signaling 5	Rattus norvegicus	56-61
17013814-10	2007	The reduced burst effectiveness of GPI-defective granulocytes was maintained after treatment with phorbol 12-myristate 13-acetate, a pharmacological stimulus able to extensively recruit and to trigger intracellular protein kinase C (PKC).	Tetradecanoylphorbol Acetate	98-129	glucose-6-phosphate isomerase	Homo sapiens	35-38
17086551-2	2007	After activation of protein kinase C (PKC) with phorbol esters (PMA) or glutamate, the content of PKC and of proteins highly enriched (GAP43, Fyn, and PrP(c)) or not (MARCKS) in DRM was followed.	Tetradecanoylphorbol Acetate	64-67	growth associated protein 43	Rattus norvegicus	135-140
17155946-4	2007	Phorbol-12-myristate 13-acetate (PMA)-stimulated EPCR shedding is reduced by approximately 50% in HEK293 cells transfected with human EPCR cDNA and by 60% in human umbilical vein endothelial cells after transfection of TACE small interfering RNA (siRNA) into these cells.	Tetradecanoylphorbol Acetate	0-31	protein C receptor	Homo sapiens	49-53
17155946-4	2007	Phorbol-12-myristate 13-acetate (PMA)-stimulated EPCR shedding is reduced by approximately 50% in HEK293 cells transfected with human EPCR cDNA and by 60% in human umbilical vein endothelial cells after transfection of TACE small interfering RNA (siRNA) into these cells.	Tetradecanoylphorbol Acetate	0-31	protein C receptor	Homo sapiens	134-138
17155946-4	2007	Phorbol-12-myristate 13-acetate (PMA)-stimulated EPCR shedding is reduced by approximately 50% in HEK293 cells transfected with human EPCR cDNA and by 60% in human umbilical vein endothelial cells after transfection of TACE small interfering RNA (siRNA) into these cells.	Tetradecanoylphorbol Acetate	33-36	protein C receptor	Homo sapiens	49-53
17155946-4	2007	Phorbol-12-myristate 13-acetate (PMA)-stimulated EPCR shedding is reduced by approximately 50% in HEK293 cells transfected with human EPCR cDNA and by 60% in human umbilical vein endothelial cells after transfection of TACE small interfering RNA (siRNA) into these cells.	Tetradecanoylphorbol Acetate	33-36	protein C receptor	Homo sapiens	134-138
17112475-8	2007	Both Cox-2a and Cox-2b expression are inducible in the kidney when fish are exposed to tetradecanoylphorbol acetate.	Tetradecanoylphorbol Acetate	87-115	prostaglandin-endoperoxide synthase 2a	Danio rerio	5-11
17200179-0	2007	Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	186-217	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	149-157
17200179-2	2007	In this study, we show that phorbol 12-myristate 13-acetate (PMA) is a potent stimulator for MUC5B gene expression under air-liquid interface conditions in three airway epithelial cell systems: primary cultures of normal human bronchial epithelial cells, the immortalized normal bronchial epithelial cell line HBE1, and the human lung adenocarcinoma cell line A549.	Tetradecanoylphorbol Acetate	28-59	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	93-98
17200179-2	2007	In this study, we show that phorbol 12-myristate 13-acetate (PMA) is a potent stimulator for MUC5B gene expression under air-liquid interface conditions in three airway epithelial cell systems: primary cultures of normal human bronchial epithelial cells, the immortalized normal bronchial epithelial cell line HBE1, and the human lung adenocarcinoma cell line A549.	Tetradecanoylphorbol Acetate	28-59	hemoglobin subunit epsilon 1	Homo sapiens	310-314
17200179-2	2007	In this study, we show that phorbol 12-myristate 13-acetate (PMA) is a potent stimulator for MUC5B gene expression under air-liquid interface conditions in three airway epithelial cell systems: primary cultures of normal human bronchial epithelial cells, the immortalized normal bronchial epithelial cell line HBE1, and the human lung adenocarcinoma cell line A549.	Tetradecanoylphorbol Acetate	61-64	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	93-98
17200179-2	2007	In this study, we show that phorbol 12-myristate 13-acetate (PMA) is a potent stimulator for MUC5B gene expression under air-liquid interface conditions in three airway epithelial cell systems: primary cultures of normal human bronchial epithelial cells, the immortalized normal bronchial epithelial cell line HBE1, and the human lung adenocarcinoma cell line A549.	Tetradecanoylphorbol Acetate	61-64	hemoglobin subunit epsilon 1	Homo sapiens	310-314
17200179-5	2007	Regarding downstream transduction, PMA-induced MUC5B expression was sensitive to inhibitors and dominant-negative expression of signaling molecules involved in Ras/mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase1-mediated c-Jun N-terminal kinase and p38 pathways.	Tetradecanoylphorbol Acetate	35-38	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	47-52
17200179-7	2007	These results demonstrate for the first time that PMA-stimulated MUC5AC and MUC5B expressions are regulated through distinctive epidermal growth factor receptor/extracellular regulated kinase-dependent and -independent signaling pathways.	Tetradecanoylphorbol Acetate	50-53	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	76-81
17203971-1	2007	Exposure of murine skin to tumor-promoting agents such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA) causes up-regulation of cyclooxygenase-2 (COX-2) and increased prostaglandin (PG) synthesis.	Tetradecanoylphorbol Acetate	58-95	prostaglandin-endoperoxide synthase 2	Mus musculus	126-142
17203971-1	2007	Exposure of murine skin to tumor-promoting agents such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA) causes up-regulation of cyclooxygenase-2 (COX-2) and increased prostaglandin (PG) synthesis.	Tetradecanoylphorbol Acetate	58-95	prostaglandin-endoperoxide synthase 2	Mus musculus	144-149
17203971-1	2007	Exposure of murine skin to tumor-promoting agents such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA) causes up-regulation of cyclooxygenase-2 (COX-2) and increased prostaglandin (PG) synthesis.	Tetradecanoylphorbol Acetate	97-100	prostaglandin-endoperoxide synthase 2	Mus musculus	126-142
17203971-1	2007	Exposure of murine skin to tumor-promoting agents such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA) causes up-regulation of cyclooxygenase-2 (COX-2) and increased prostaglandin (PG) synthesis.	Tetradecanoylphorbol Acetate	97-100	prostaglandin-endoperoxide synthase 2	Mus musculus	144-149
17203971-3	2007	However, we previously demonstrated that K14.COX-2 transgenic (TG) mice that overexpressed COX-2 in the epidermis were unexpectedly resistant to tumor development under the classical 7,12-dimethylbenz[a]anthracene-TPA protocol.	Tetradecanoylphorbol Acetate	214-217	prostaglandin-endoperoxide synthase 2	Mus musculus	45-50
17203971-3	2007	However, we previously demonstrated that K14.COX-2 transgenic (TG) mice that overexpressed COX-2 in the epidermis were unexpectedly resistant to tumor development under the classical 7,12-dimethylbenz[a]anthracene-TPA protocol.	Tetradecanoylphorbol Acetate	214-217	prostaglandin-endoperoxide synthase 2	Mus musculus	91-96
17143503-3	2007	In the present study, we found that 6-MITC suppressed the expression of cyclooxygenase-2 (COX-2) induced by lipopolysaccharide (LPS), interferon-gamma (IFN-gamma), but did not suppress that induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), in murine macrophage RAW264.	Tetradecanoylphorbol Acetate	201-237	prostaglandin-endoperoxide synthase 2	Mus musculus	90-95
17143503-3	2007	In the present study, we found that 6-MITC suppressed the expression of cyclooxygenase-2 (COX-2) induced by lipopolysaccharide (LPS), interferon-gamma (IFN-gamma), but did not suppress that induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), in murine macrophage RAW264.	Tetradecanoylphorbol Acetate	239-242	prostaglandin-endoperoxide synthase 2	Mus musculus	90-95
17143503-7	2007	Finally, TPA stimulated the activation of CREB and AP-1, but 6-MITC did not block TPA-induced COX-2 expression.	Tetradecanoylphorbol Acetate	9-12	jun proto-oncogene	Mus musculus	51-55
17143503-8	2007	These results suggest that LPS, IFN-gamma and TPA regulate COX-2 expression through different mechanisms, and 6-MITC acts as a potent inhibitor of COX-2 expression induced by LPS or IFN-gamma.	Tetradecanoylphorbol Acetate	46-49	prostaglandin-endoperoxide synthase 2	Mus musculus	59-64
17178875-8	2006	Functional studies revealed that, notably, androgens modulate phorbol 12-myristate 13-acetate (PMA)-induced apoptosis in LNCaP cells, an effect that is dependent on PKCdelta.	Tetradecanoylphorbol Acetate	62-93	protein kinase C delta	Homo sapiens	165-173
17178875-8	2006	Functional studies revealed that, notably, androgens modulate phorbol 12-myristate 13-acetate (PMA)-induced apoptosis in LNCaP cells, an effect that is dependent on PKCdelta.	Tetradecanoylphorbol Acetate	95-98	protein kinase C delta	Homo sapiens	165-173
17106253-9	2006	Dot blot indicated that Bicyclol inhibited mRNA expressions of H-ras, c-myc and PKCalpha genes by TPA-stimulation.	Tetradecanoylphorbol Acetate	98-101	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	70-75
17229087-8	2006	In contrast, phorbol 12-myristate 13-acetate and ionophore treatment caused robust induction of COX-2 and PGE(2) in both genotypes.	Tetradecanoylphorbol Acetate	13-44	cytochrome c oxidase II, mitochondrial	Mus musculus	96-101
16999939-4	2006	We have attempted to unravel the signal transduction pathways involved in elevated COX-2 expression in mouse skin stimulated with a prototype tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and its modulation by resveratrol, a phytoalexin known to exert potential chemopreventive effects.	Tetradecanoylphorbol Acetate	157-193	prostaglandin-endoperoxide synthase 2	Mus musculus	83-88
16999939-4	2006	We have attempted to unravel the signal transduction pathways involved in elevated COX-2 expression in mouse skin stimulated with a prototype tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and its modulation by resveratrol, a phytoalexin known to exert potential chemopreventive effects.	Tetradecanoylphorbol Acetate	195-198	prostaglandin-endoperoxide synthase 2	Mus musculus	83-88
16999939-5	2006	Our study revealed that topical application of TPA induced COX-2 expression in mouse skin via activation of nuclear factor-kappaB (NF-kappaB), which is regulated by upstream IkappaB kinase (IKK) or differentially by mitogen-activated protein (MAP) kinases.	Tetradecanoylphorbol Acetate	47-50	prostaglandin-endoperoxide synthase 2	Mus musculus	59-64
16999939-6	2006	Besides NF-kappaB, the p38 MAP kinase-mediated activation of activator protein-1 (AP-1) has also been attributed to TPA-induced COX-2 expression in mouse skin.	Tetradecanoylphorbol Acetate	116-119	mitogen-activated protein kinase 14	Mus musculus	23-26
16999939-6	2006	Besides NF-kappaB, the p38 MAP kinase-mediated activation of activator protein-1 (AP-1) has also been attributed to TPA-induced COX-2 expression in mouse skin.	Tetradecanoylphorbol Acetate	116-119	jun proto-oncogene	Mus musculus	61-80
16999939-6	2006	Besides NF-kappaB, the p38 MAP kinase-mediated activation of activator protein-1 (AP-1) has also been attributed to TPA-induced COX-2 expression in mouse skin.	Tetradecanoylphorbol Acetate	116-119	jun proto-oncogene	Mus musculus	82-86
16999939-6	2006	Besides NF-kappaB, the p38 MAP kinase-mediated activation of activator protein-1 (AP-1) has also been attributed to TPA-induced COX-2 expression in mouse skin.	Tetradecanoylphorbol Acetate	116-119	prostaglandin-endoperoxide synthase 2	Mus musculus	128-133
16999939-7	2006	Among the MAP kinases, extracellular signal-regulated protein kinase (ERK) and p38 MAP kinase have been shown to regulate TPA-induced NF-kappaB activation, while p38 MAP kinase and c-Jun-N-terminal kinase are preferentially involved in TPA-induced activation of AP-1 in mouse skin in vivo.	Tetradecanoylphorbol Acetate	122-125	mitogen-activated protein kinase 14	Mus musculus	79-82
16999939-7	2006	Among the MAP kinases, extracellular signal-regulated protein kinase (ERK) and p38 MAP kinase have been shown to regulate TPA-induced NF-kappaB activation, while p38 MAP kinase and c-Jun-N-terminal kinase are preferentially involved in TPA-induced activation of AP-1 in mouse skin in vivo.	Tetradecanoylphorbol Acetate	122-125	jun proto-oncogene	Mus musculus	262-266
16999939-7	2006	Among the MAP kinases, extracellular signal-regulated protein kinase (ERK) and p38 MAP kinase have been shown to regulate TPA-induced NF-kappaB activation, while p38 MAP kinase and c-Jun-N-terminal kinase are preferentially involved in TPA-induced activation of AP-1 in mouse skin in vivo.	Tetradecanoylphorbol Acetate	236-239	mitogen-activated protein kinase 14	Mus musculus	79-82
16999939-7	2006	Among the MAP kinases, extracellular signal-regulated protein kinase (ERK) and p38 MAP kinase have been shown to regulate TPA-induced NF-kappaB activation, while p38 MAP kinase and c-Jun-N-terminal kinase are preferentially involved in TPA-induced activation of AP-1 in mouse skin in vivo.	Tetradecanoylphorbol Acetate	236-239	mitogen-activated protein kinase 14	Mus musculus	162-165
16999939-8	2006	This commentary focuses on resveratrol modulation of intracellular signaling pathways involved in aberrant COX-2 expression in TPA-stimulated mouse skin to delineate molecular mechanisms underlying antitumor promoting effects of resveratrol.	Tetradecanoylphorbol Acetate	127-130	prostaglandin-endoperoxide synthase 2	Mus musculus	107-112
17010316-1	2006	Recently we demonstrated that PP2 (4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine), a potent and selective inhibitor of the Src-family tyrosine kinase, markedly enhanced Ras-independent activation of Raf-1 by the combination of phorbol myristate acetate (PMA) and hydrogen peroxide (H(2)O(2)).	Tetradecanoylphorbol Acetate	246-271	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	30-33
17010316-1	2006	Recently we demonstrated that PP2 (4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine), a potent and selective inhibitor of the Src-family tyrosine kinase, markedly enhanced Ras-independent activation of Raf-1 by the combination of phorbol myristate acetate (PMA) and hydrogen peroxide (H(2)O(2)).	Tetradecanoylphorbol Acetate	273-276	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	30-33
16996475-8	2006	Analyses of PKC isoforms suggest that CREB phosphorylation is mediated by PKC epsilon translocating into nucleus only with TPA stimulation.	Tetradecanoylphorbol Acetate	123-126	protein kinase C, epsilon	Mus musculus	74-85
16950780-5	2006	In this study, we showed that mutation to arginines of the four corresponding sites in the C1b domain of PKCdelta abolished its high potency for phorbol 12,13-dibutyrate in vitro, with only marginal remaining activity for phorbol 12-myristate 13-acetate in vivo.	Tetradecanoylphorbol Acetate	222-253	protein kinase C delta	Homo sapiens	105-113
16475165-0	2006	Knockdown of NFAT3 blocked TPA-induced COX-2 and iNOS expression, and enhanced cell transformation in Cl41 cells.	Tetradecanoylphorbol Acetate	27-30	prostaglandin-endoperoxide synthase 2	Mus musculus	39-44
16475165-8	2006	At the same time, TPA-induced expression of both COX-2 and inducible nitric oxide synthase (iNOS) were blocked.	Tetradecanoylphorbol Acetate	18-21	prostaglandin-endoperoxide synthase 2	Mus musculus	49-54
17047069-6	2006	In HT-29 colon cancer cells, carcinogenic agent 12-O-tetradecanoylphorbol-13-acetate (TPA) activated extracellular signal-regulated kinase (ERK) that led to COX-2 expression and selenium blocked the TPA-induced ERK and COX-2 activation via AMPK.	Tetradecanoylphorbol Acetate	48-84	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	240-244
17047069-6	2006	In HT-29 colon cancer cells, carcinogenic agent 12-O-tetradecanoylphorbol-13-acetate (TPA) activated extracellular signal-regulated kinase (ERK) that led to COX-2 expression and selenium blocked the TPA-induced ERK and COX-2 activation via AMPK.	Tetradecanoylphorbol Acetate	86-89	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	240-244
16969515-7	2006	Furthermore, it showed that AT inhibited the TPA-induced expression of COX-2 protein and ornithine decarboxylase (ODC) activity in epidermis.	Tetradecanoylphorbol Acetate	45-48	cytochrome c oxidase II, mitochondrial	Mus musculus	71-76
16337085-8	2006	NaBu prevented the TPA-induced GJIC inhibition via ERK1/2 inactivation whilst TSA restored the H(2)O(2)-induced GJIC inhibition and Cx43 hyperphosphorylation by preventing p38 MAP kinase.	Tetradecanoylphorbol Acetate	19-22	mitogen activated protein kinase 3	Rattus norvegicus	51-57
16835219-3	2006	In contrast to other cellular sialidases Neu2, Neu3, and Neu4, whose expression either remains unchanged or is down-regulated, Neu1 mRNA, protein and activity are specifically increased during the phorbol 12-myristate 13-acetate-induced differentiation, consistent with a significant induction of the transcriptional activity of the Neu1 gene promoter.	Tetradecanoylphorbol Acetate	197-228	neuraminidase 1	Homo sapiens	127-131
16835219-3	2006	In contrast to other cellular sialidases Neu2, Neu3, and Neu4, whose expression either remains unchanged or is down-regulated, Neu1 mRNA, protein and activity are specifically increased during the phorbol 12-myristate 13-acetate-induced differentiation, consistent with a significant induction of the transcriptional activity of the Neu1 gene promoter.	Tetradecanoylphorbol Acetate	197-228	neuraminidase 1	Homo sapiens	333-337
16939222-4	2006	Following an acute exposure (i.e., within 2 to 6 h) to PMA (50 nM), a mitogenic effect was observed on WISP-2/CCN5-positive breast tumor cell lines, including MCF-7, ZR-75-1 and SKBR-3 cells, and induction of WISP-2/CCN5 mRNA expression paralleled the observed mitogenic proliferation.	Tetradecanoylphorbol Acetate	55-58	cellular communication network factor 5	Homo sapiens	103-109
16939222-4	2006	Following an acute exposure (i.e., within 2 to 6 h) to PMA (50 nM), a mitogenic effect was observed on WISP-2/CCN5-positive breast tumor cell lines, including MCF-7, ZR-75-1 and SKBR-3 cells, and induction of WISP-2/CCN5 mRNA expression paralleled the observed mitogenic proliferation.	Tetradecanoylphorbol Acetate	55-58	cellular communication network factor 5	Homo sapiens	110-114
16939222-4	2006	Following an acute exposure (i.e., within 2 to 6 h) to PMA (50 nM), a mitogenic effect was observed on WISP-2/CCN5-positive breast tumor cell lines, including MCF-7, ZR-75-1 and SKBR-3 cells, and induction of WISP-2/CCN5 mRNA expression paralleled the observed mitogenic proliferation.	Tetradecanoylphorbol Acetate	55-58	cellular communication network factor 5	Homo sapiens	209-215
16939222-4	2006	Following an acute exposure (i.e., within 2 to 6 h) to PMA (50 nM), a mitogenic effect was observed on WISP-2/CCN5-positive breast tumor cell lines, including MCF-7, ZR-75-1 and SKBR-3 cells, and induction of WISP-2/CCN5 mRNA expression paralleled the observed mitogenic proliferation.	Tetradecanoylphorbol Acetate	55-58	cellular communication network factor 5	Homo sapiens	216-220
16912315-8	2006	First, ectopic M2L expression hampered ERK2 phosphorylation induced by exposure to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	83-108	hypothetical protein	Vaccinia virus	15-18
16740634-10	2006	Using ChIP assays and immunoprecipitation, we further demonstrated that p53 interacts with Sp1 to suppress both the constitutive and 12-O-tetradecanoylphorbol-13-acetate-stimulated expression of the MnSOD gene.	Tetradecanoylphorbol Acetate	133-169	superoxide dismutase 2	Homo sapiens	199-204
16704976-1	2006	Voltage-gated calcium channels (Ca(v)) 2.2 currents are potentiated by phorbol-12-myristate, 13-acetate (PMA), whereas Ca(v) 2.3 currents are increased by both PMA and acetyl-beta-methylcholine (MCh).	Tetradecanoylphorbol Acetate	160-163	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	119-128
16849550-3	2006	We report here that deletion of EphA2 in mouse led to markedly enhanced susceptibility to 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA) two-stage skin carcinogenesis.	Tetradecanoylphorbol Acetate	121-157	Eph receptor A2	Mus musculus	32-37
16849558-5	2006	Osteopontin is minimally expressed in normal epidermis, but on treatment with TPA its expression is highly induced.	Tetradecanoylphorbol Acetate	78-81	secreted phosphoprotein 1	Mus musculus	0-11
16849558-7	2006	Epidermis from osteopontin-null and WT mice treated with TPA thrice or with DMBA followed by TPA for 11 weeks showed a similar increase in epidermal hyperplasia, suggesting that osteopontin does not mediate TPA-induced cell proliferation.	Tetradecanoylphorbol Acetate	57-60	secreted phosphoprotein 1	Mus musculus	178-189
16849558-7	2006	Epidermis from osteopontin-null and WT mice treated with TPA thrice or with DMBA followed by TPA for 11 weeks showed a similar increase in epidermal hyperplasia, suggesting that osteopontin does not mediate TPA-induced cell proliferation.	Tetradecanoylphorbol Acetate	93-96	secreted phosphoprotein 1	Mus musculus	178-189
16849558-7	2006	Epidermis from osteopontin-null and WT mice treated with TPA thrice or with DMBA followed by TPA for 11 weeks showed a similar increase in epidermal hyperplasia, suggesting that osteopontin does not mediate TPA-induced cell proliferation.	Tetradecanoylphorbol Acetate	93-96	secreted phosphoprotein 1	Mus musculus	178-189
16052516-6	2006	Pretreatment with the PKCdelta-selective inhibitor rottlerin or transfection with PKCdelta siRNA inhibited PMA-induced FLIP expression, which identifies a role for PKCdelta in FLIP induction.	Tetradecanoylphorbol Acetate	107-110	protein kinase C delta	Homo sapiens	82-90
16849575-9	2006	We conclude that the differential effect on cellular proliferation induced by bryostatin 1 compared with PMA reflects the differential suppression of PKCdelta.	Tetradecanoylphorbol Acetate	105-108	protein kinase C delta	Homo sapiens	150-158
16052516-6	2006	Pretreatment with the PKCdelta-selective inhibitor rottlerin or transfection with PKCdelta siRNA inhibited PMA-induced FLIP expression, which identifies a role for PKCdelta in FLIP induction.	Tetradecanoylphorbol Acetate	107-110	protein kinase C delta	Homo sapiens	82-90
16504566-7	2006	We observed that a rapid and detectable decrease in Raf-1 protein levels was induced by methylglyoxal, which was accelerated by treating with a Raf-1 activator, phorbol-12-myristate-13-acetate, and by expressing active forms of Raf-1 and Ras.	Tetradecanoylphorbol Acetate	161-192	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	52-57
16491121-3	2006	Interaction between Smad6 and PrKX was also confirmed in human myeloid HL-60 cells following their phorbol 12-myristate 13-acetate (PMA)-induced differentiation into macrophages.	Tetradecanoylphorbol Acetate	99-130	protein kinase X-linked	Homo sapiens	30-34
16491121-3	2006	Interaction between Smad6 and PrKX was also confirmed in human myeloid HL-60 cells following their phorbol 12-myristate 13-acetate (PMA)-induced differentiation into macrophages.	Tetradecanoylphorbol Acetate	132-135	protein kinase X-linked	Homo sapiens	30-34
16504566-8	2006	Moreover, immunoprecipitation and immunoblotting assays showed that co-treatment of cells with methylglyoxal and phorbol-12-myristate-13-acetate caused dramatic ubiquitination in both total intracellular proteins and Raf-1.	Tetradecanoylphorbol Acetate	113-144	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	217-222
16809777-3	2006	The ectodomain cleavage of Pref-1 is markedly enhanced by phorbol 12-myristate 13-acetate in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	58-89	delta like non-canonical Notch ligand 1	Mus musculus	27-33
16950644-11	2006	In addition, rottlerin, a specific inhibitor of PKC-delta, can reverse the suppression of adipogenesis mediated by 12-O-tetradecanoyl-phorbol-13-acetate, transforming growth factor-beta1, and epidermal growth factor.	Tetradecanoylphorbol Acetate	115-152	protein kinase C delta	Homo sapiens	48-57
17329956-6	2006	Thus, cyclin D1 and p21Waf1 expressions are considered to be induced via PKC and extracellular signal-regulated kinase/mitogen-activated protein kinase (MAPK/ERK) pathways in TPA-treated HL60 cells.	Tetradecanoylphorbol Acetate	175-178	cyclin D1	Homo sapiens	6-15
16564619-3	2006	Here, using both Ca2+-imaging and patch-clamp methods, we show that PMA-induced activation of PKCepsilon is essential for increased sensitivity of desensitized TRPV1.	Tetradecanoylphorbol Acetate	68-71	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	160-165
16713561-4	2006	Cyld-/- tumors and keratinocytes treated with 12-O-tetradecanoylphorbol-13 acetate (TPA) or UV light are hyperproliferative and have elevated cyclin D1 levels.	Tetradecanoylphorbol Acetate	46-82	CYLD lysine 63 deubiquitinase	Mus musculus	0-4
16713561-4	2006	Cyld-/- tumors and keratinocytes treated with 12-O-tetradecanoylphorbol-13 acetate (TPA) or UV light are hyperproliferative and have elevated cyclin D1 levels.	Tetradecanoylphorbol Acetate	84-87	CYLD lysine 63 deubiquitinase	Mus musculus	0-4
16437695-7	2005	Phorbol myristate acetate (PMA) -- stimulated neutrophilsproduced less reactive oxidants in liver cirrhosis patients than in healthy subjects (MIF of R123: 42.7+/-14.6 vs 50.2+/-13.3, P&lt;0.01).	Tetradecanoylphorbol Acetate	0-25	macrophage migration inhibitory factor	Homo sapiens	143-146
16713561-6	2006	In Cyld+/+ keratinocytes, TPA or UV light triggers the translocation of Cyld from the cytoplasm to the perinuclear region, where Cyld binds and deubiquitinates Bcl-3, thereby preventing nuclear accumulation of Bcl-3 and p50/Bcl-3- or p52/Bcl-3-dependent proliferation.	Tetradecanoylphorbol Acetate	26-29	CYLD lysine 63 deubiquitinase	Mus musculus	3-7
16713561-6	2006	In Cyld+/+ keratinocytes, TPA or UV light triggers the translocation of Cyld from the cytoplasm to the perinuclear region, where Cyld binds and deubiquitinates Bcl-3, thereby preventing nuclear accumulation of Bcl-3 and p50/Bcl-3- or p52/Bcl-3-dependent proliferation.	Tetradecanoylphorbol Acetate	26-29	CYLD lysine 63 deubiquitinase	Mus musculus	72-76
16713561-6	2006	In Cyld+/+ keratinocytes, TPA or UV light triggers the translocation of Cyld from the cytoplasm to the perinuclear region, where Cyld binds and deubiquitinates Bcl-3, thereby preventing nuclear accumulation of Bcl-3 and p50/Bcl-3- or p52/Bcl-3-dependent proliferation.	Tetradecanoylphorbol Acetate	26-29	CYLD lysine 63 deubiquitinase	Mus musculus	72-76
16437695-7	2005	Phorbol myristate acetate (PMA) -- stimulated neutrophilsproduced less reactive oxidants in liver cirrhosis patients than in healthy subjects (MIF of R123: 42.7+/-14.6 vs 50.2+/-13.3, P&lt;0.01).	Tetradecanoylphorbol Acetate	27-30	macrophage migration inhibitory factor	Homo sapiens	143-146
16236821-3	2006	In the course of studies exploring PKC-delta phosphorylation mechanisms in cardiomyocytes, we have demonstrated that a BD Transduction Laboratories anti-PKC-delta MAb (generally viewed as an anti-PKC-delta protein antibody) recognizes PKC-delta in resting, but not in PMA-treated, cardiomyocytes.	Tetradecanoylphorbol Acetate	268-271	protein kinase C delta	Homo sapiens	153-162
16236821-3	2006	In the course of studies exploring PKC-delta phosphorylation mechanisms in cardiomyocytes, we have demonstrated that a BD Transduction Laboratories anti-PKC-delta MAb (generally viewed as an anti-PKC-delta protein antibody) recognizes PKC-delta in resting, but not in PMA-treated, cardiomyocytes.	Tetradecanoylphorbol Acetate	268-271	protein kinase C delta	Homo sapiens	153-162
16437695-9	2005	sVCAM-1, sICAM-1, sE-selectin concentrations correlated negatively with the oxygen free radical production (MIF of R123) in neutrophils after PMA stimulation in liver cirrhosis patients (r-0.45, P&lt;0.05; r-0.41, P&lt;0.05; r-0.39, P&lt;0.05, respectively).	Tetradecanoylphorbol Acetate	142-145	macrophage migration inhibitory factor	Homo sapiens	108-111
16236821-3	2006	In the course of studies exploring PKC-delta phosphorylation mechanisms in cardiomyocytes, we have demonstrated that a BD Transduction Laboratories anti-PKC-delta MAb (generally viewed as an anti-PKC-delta protein antibody) recognizes PKC-delta in resting, but not in PMA-treated, cardiomyocytes.	Tetradecanoylphorbol Acetate	268-271	protein kinase C delta	Homo sapiens	153-162
16236821-4	2006	The observations that PKC-delta immunoreactivity is preserved when cultures are treated with PMA in the presence of a the PKC inhibitor GF-109203X and that PKC-delta immunoreactivity is restored by in vitro acid phosphatase treatment indicate that the epitope recognized by the BD Transduction Laboratories anti-PKC-delta MAb is masked by phosphorylation.	Tetradecanoylphorbol Acetate	93-96	protein kinase C delta	Homo sapiens	22-31
16351709-7	2005	Furthermore, the TPA-mediated post-transcriptional mechanism of p21WAF1-enhanced expression in RD cells is due to activation of the MEK/ERK pathway, as shown by transfections with constitutively active MEK1 or MEK2, which induces p21WAF1 expression, and with ERK1 and ERK2 siRNA, which prevents p21WAF1 expression.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase kinase 2	Homo sapiens	210-214
16236821-4	2006	The observations that PKC-delta immunoreactivity is preserved when cultures are treated with PMA in the presence of a the PKC inhibitor GF-109203X and that PKC-delta immunoreactivity is restored by in vitro acid phosphatase treatment indicate that the epitope recognized by the BD Transduction Laboratories anti-PKC-delta MAb is masked by phosphorylation.	Tetradecanoylphorbol Acetate	93-96	protein kinase C delta	Homo sapiens	22-25
16244358-14	2006	Overall, our data suggest that abrogation of BPDE-induced p53 response and of NFkappaB activation by TPA is mediated by impairment of the signaling pathway involving p38 MAPK.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase 14	Mus musculus	166-174
16351709-9	2005	Similarly, myogenin and MyoD expression is induced both by U0126 and TPA and is prevented by p38 inhibition.	Tetradecanoylphorbol Acetate	69-72	myogenin	Homo sapiens	11-19
16293250-2	2005	Costimulation of Jurkat cells with 12-O-tetradecanoylphorbol-13-acetate and A23187 leads to a rapid phosphorylation of TAK1 and TAK1-binding protein 1 (TAB1), critical for TAK1 activation.	Tetradecanoylphorbol Acetate	35-71	TGF-beta activated kinase 1 (MAP3K7) binding protein 1	Homo sapiens	128-150
16673205-7	2006	Minodronate inhibited Raf-1, MEK1/2 and p44/p42 MAP kinase phosphorylation induced by TPA.	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase 3	Mus musculus	40-43
16673205-7	2006	Minodronate inhibited Raf-1, MEK1/2 and p44/p42 MAP kinase phosphorylation induced by TPA.	Tetradecanoylphorbol Acetate	86-89	cyclin-dependent kinase 20	Mus musculus	44-47
16324151-5	2005	The nuclear fraction of HUVECs exhibits an NAD(P)H-dependent superoxide-producing activity in a manner dependent on Nox4, which activity can be enhanced upon cell stimulation with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	180-211	NADPH oxidase 4	Homo sapiens	116-120
16455999-4	2006	The inhibitory effect of PMA was abolished by pretreatment of cells with specific PKC inhibitor GF109203X, suggesting that the PKC pathway negatively regulates Akt activation.	Tetradecanoylphorbol Acetate	25-28	protein kinase C delta	Homo sapiens	82-85
16455999-4	2006	The inhibitory effect of PMA was abolished by pretreatment of cells with specific PKC inhibitor GF109203X, suggesting that the PKC pathway negatively regulates Akt activation.	Tetradecanoylphorbol Acetate	25-28	protein kinase C delta	Homo sapiens	127-130
16338928-8	2006	TPA also attenuated IGF-1 and epidermal growth factor-induced phospho-Ser-473-Akt, reduced Akt kinase activity, and blocked IGF-1 protection from UVC-induced apoptosis.	Tetradecanoylphorbol Acetate	0-3	insulin-like growth factor 1	Mus musculus	20-25
16338928-8	2006	TPA also attenuated IGF-1 and epidermal growth factor-induced phospho-Ser-473-Akt, reduced Akt kinase activity, and blocked IGF-1 protection from UVC-induced apoptosis.	Tetradecanoylphorbol Acetate	0-3	insulin-like growth factor 1	Mus musculus	124-129
16271356-3	2005	Applied in concentrations of 5-25 nM, PMA induced a fast and lasting decrease of the transepithelial electrical resistance (TER), which could be blocked by rottlerin, indicating the involvement of PKCdelta in signal transduction.	Tetradecanoylphorbol Acetate	38-41	protein kinase C delta	Homo sapiens	197-205
16278664-6	2005	Using CHO-M2 cells defective in shedding, we demonstrated that the basal CA IX ectodomain release does not require a functional TNFalpha-converting enzyme (TACE/ADAM17), whereas the activation of CA IX shedding by both phorbol-12-myristate-13-acetate and pervanadate is TACE-dependent.	Tetradecanoylphorbol Acetate	219-250	carbonic anhydrase 9	Homo sapiens	73-78
16170341-5	2006	Here, we show that amino-acid depletion completely blocks insulin- and TPA-induced Rheb activation.	Tetradecanoylphorbol Acetate	71-74	Ras homolog, mTORC1 binding	Homo sapiens	83-87
16278664-6	2005	Using CHO-M2 cells defective in shedding, we demonstrated that the basal CA IX ectodomain release does not require a functional TNFalpha-converting enzyme (TACE/ADAM17), whereas the activation of CA IX shedding by both phorbol-12-myristate-13-acetate and pervanadate is TACE-dependent.	Tetradecanoylphorbol Acetate	219-250	carbonic anhydrase 9	Homo sapiens	196-201
16534736-0	2006	Inhibitory effects of ginsenoside-Rb1 on activation of the 12-O-tetradecanoylphorbol 13-acetate-induced cyclooxygenase-2 promoter.	Tetradecanoylphorbol Acetate	59-95	RB transcriptional corepressor 1	Homo sapiens	34-37
16306704-0	2005	Phorbol myristate acetate induces neutrophil death through activation of p38 mitogen-activated protein kinase that requires endogenous reactive oxygen species other than HOCl.	Tetradecanoylphorbol Acetate	0-25	mitogen-activated protein kinase 14	Mus musculus	73-76
16534736-1	2006	We studied the inhibitory effects of ginsenoside-Rb1 (1) on 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced transcriptional activation of the cyclooxygenase-2 (COX-2) promoter.	Tetradecanoylphorbol Acetate	60-96	RB transcriptional corepressor 1	Homo sapiens	49-52
16424000-7	2006	The proapoptotic activity of PKCdelta coupled with its ability to suppress TPA-induced expression of proinflammatory cytokines, COX-2 expression, and the phosphorylation of Akt and p38 may play roles in the suppression of TPA-promoted development of SCC.	Tetradecanoylphorbol Acetate	75-78	prostaglandin-endoperoxide synthase 2	Mus musculus	128-133
16424000-7	2006	The proapoptotic activity of PKCdelta coupled with its ability to suppress TPA-induced expression of proinflammatory cytokines, COX-2 expression, and the phosphorylation of Akt and p38 may play roles in the suppression of TPA-promoted development of SCC.	Tetradecanoylphorbol Acetate	75-78	mitogen-activated protein kinase 14	Mus musculus	181-184
17329956-0	2006	PKC pathway and ERK/MAPK pathway are required for induction of cyclin D1 and p21Waf1 during 12-o-tetradecanoylphorbol 13-acetate-induced differentiation of myeloleukemia cells.	Tetradecanoylphorbol Acetate	92-128	cyclin D1	Homo sapiens	63-72
17329956-1	2006	Treatment of human promyelocytic leukemia cell HL60 with 12-o-tetradecanoylphorbol 13-acetate (TPA) induces growth arrest, differentiation towards the monocyte/macrophage lineage, and expression of cell cycle-regulating genes cyclin D1 and p21Waf1.	Tetradecanoylphorbol Acetate	57-93	cyclin D1	Homo sapiens	226-235
16901728-6	2006	Notably, a high-affinity conformation of LFA-1 is mobile on resting cells but immobile on phorbol-12-myristate-13-acetate-activated cells.	Tetradecanoylphorbol Acetate	90-121	integrin subunit alpha L	Homo sapiens	41-46
16939918-6	2006	Similarly, the phosphorylation of PKC and P44/42 MAPKs was correlated with the liver function, and highly enhanced PKC and P44/42 MAPKs activity was observed in IP and IR+PMA groups, but decreased activity in IR and IP+CHE groups.	Tetradecanoylphorbol Acetate	171-174	mitogen activated protein kinase 3	Rattus norvegicus	123-126
16849558-10	2006	These studies are the first to show that induction of the matricellular protein osteopontin facilitates DMBA/TPA-induced cutaneous carcinogenesis most likely through prevention of apoptosis.	Tetradecanoylphorbol Acetate	109-112	secreted phosphoprotein 1	Mus musculus	80-91
17329956-1	2006	Treatment of human promyelocytic leukemia cell HL60 with 12-o-tetradecanoylphorbol 13-acetate (TPA) induces growth arrest, differentiation towards the monocyte/macrophage lineage, and expression of cell cycle-regulating genes cyclin D1 and p21Waf1.	Tetradecanoylphorbol Acetate	95-98	cyclin D1	Homo sapiens	226-235
17329956-3	2006	Secondly, we demonstrated the signal transduction pathways of cyclin D1 and p21Waf1 expressions in TPA-treated HL60 cells.	Tetradecanoylphorbol Acetate	99-102	cyclin D1	Homo sapiens	62-71
16849575-2	2006	Although bryostatin 1, like phorbol 12-myristate 13-acetate (PMA), is a potent activator of protein kinase C (PKC), it induces only a subset of those responses induced by PMA and antagonizes others.	Tetradecanoylphorbol Acetate	61-64	protein kinase C delta	Homo sapiens	110-113
16306704-4	2005	Of note, p38 mitogen-activated protein kinase was activated by phorbol 12-myristate 13-acetate in normal and myeloperoxidase-deficient neutrophils lacking production of HOCl, whereas no activation was observed in NADPH oxidase-deficient neutrophils.	Tetradecanoylphorbol Acetate	63-94	mitogen-activated protein kinase 14	Mus musculus	9-12
17329956-4	2006	Induction of cyclin D1 expression in TPA-treated HL60 cells was inhibited with protein kinase C (PKC) inhibitor bisindolylmaleimide I and mitogen activated protein kinase kinase (MEK) inhibitor PD98059.	Tetradecanoylphorbol Acetate	37-40	cyclin D1	Homo sapiens	13-22
16277019-9	2005	Binding of activator protein-1 (AP-1) to the 12-tetradecanoylphorbol-13-acetate-responsive element (TRE) sequence in LPS-stimulated cells was inhibited by bis-FA at 1 microM and dehydrodiisoeugenol at 0.1 microM, but not by the parent monomers isoeugenol and ferulic acid.	Tetradecanoylphorbol Acetate	45-79	jun proto-oncogene	Mus musculus	11-30
16618699-5	2006	Pretreatment of JB6 cells with C3G inhibited UVB- and TPA-induced transactivation of NF-kappaB and AP-1 and expression of cyclooxygenase-2 and tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	54-57	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	99-103
16289105-2	2005	The results showed that saikosaponin-d potently suppressed both early (CD69) and late (CD71) expressions of mouse T cells stimulated with Con A or PMA.	Tetradecanoylphorbol Acetate	147-150	transferrin receptor	Mus musculus	87-91
16277019-9	2005	Binding of activator protein-1 (AP-1) to the 12-tetradecanoylphorbol-13-acetate-responsive element (TRE) sequence in LPS-stimulated cells was inhibited by bis-FA at 1 microM and dehydrodiisoeugenol at 0.1 microM, but not by the parent monomers isoeugenol and ferulic acid.	Tetradecanoylphorbol Acetate	45-79	jun proto-oncogene	Mus musculus	32-36
16044159-7	2005	The induction of both Caspase-3 and apoptosis by TPA were four-fold inhibited in the skin of the Tg(ped/pea-15) compared to the nontransgenic mice, accompanied by a similarly sized reduction in TPA-induced JNK and p38 stimulation and by constitutive induction of cytoplasmic ERK activity in the transgenics.	Tetradecanoylphorbol Acetate	49-52	mitogen-activated protein kinase 14	Mus musculus	214-217
16274672-6	2005	The effects of CNTF were mimicked by the PKC activator PMA and prevented by the PKC-inhibitor chelerythrine.	Tetradecanoylphorbol Acetate	55-58	ciliary neurotrophic factor	Mus musculus	15-19
16368122-5	2006	Arsenic/TPA treatment resulted in increased expression of alpha-fetoprotein, k-ras, c-myc, estrogen receptor-alpha, cyclin D1, cdk2na, plasminogen activator inhibitor-1, cytokeratin-8, cytokeratin-18, glutathione S-transferases and insulin-like growth factor binding proteins in liver and liver tumors from both male and female mice.	Tetradecanoylphorbol Acetate	8-11	keratin 18	Mus musculus	185-199
16368122-6	2006	Arsenic/TPA also decreased the expression of BRCA1, betaine-homocysteine methyltransferase, CYP7B1, CYP2F2 and insulin-like growth factor-1 in normal and cancerous livers.	Tetradecanoylphorbol Acetate	8-11	insulin-like growth factor 1	Mus musculus	111-139
16373587-5	2006	PKC activation by 12-O-tetradecanoylphorbol 13-acetate treatment increased serine phosphorylation of FAK and FRNK.	Tetradecanoylphorbol Acetate	18-54	protein tyrosine kinase 2	Homo sapiens	109-113
16099885-4	2005	Phorbol 12-myristate 13-acetate (PMA)-stimulated PMNs adhered and migrated well and equally on the TSP-4 variants.	Tetradecanoylphorbol Acetate	0-31	thrombospondin 4	Homo sapiens	99-104
16055435-3	2005	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) in early G1 phase impaired progression of lung adenocarcinoma cells into S phase, an effect that was completely abolished by specific depletion of PKCdelta, but not PKCalpha.	Tetradecanoylphorbol Acetate	23-54	protein kinase C delta	Homo sapiens	208-216
16055435-3	2005	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) in early G1 phase impaired progression of lung adenocarcinoma cells into S phase, an effect that was completely abolished by specific depletion of PKCdelta, but not PKCalpha.	Tetradecanoylphorbol Acetate	56-59	protein kinase C delta	Homo sapiens	208-216
16702541-7	2006	In normal F1 mouse skin, the Tgfb1SPR allele is expressed at higher levels than the Tgfb1NIH allele, and this differential is accentuated by phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	141-172	transforming growth factor, beta 1	Mus musculus	29-34
16041399-5	2005	Immunohistochemical studies of mouse skin demonstrated that TPA-induced COX-2 expression was significantly inhibited by ethyl caffeate with a superior effect to that of celecoxib, a nonsteroidal anti-inflammatory drug.	Tetradecanoylphorbol Acetate	60-63	cytochrome c oxidase II, mitochondrial	Mus musculus	72-77
16099885-4	2005	Phorbol 12-myristate 13-acetate (PMA)-stimulated PMNs adhered and migrated well and equally on the TSP-4 variants.	Tetradecanoylphorbol Acetate	33-36	thrombospondin 4	Homo sapiens	99-104
16044405-9	2005	Three genes, Gsta4, Nmes1 (MGC58382), and Serpinb2, located within promotion susceptibility loci Psl1 (chr 9), Psl2 (chr 2), and Psl3 (chr 1), respectively, were identified in this analysis as potential candidates for modifiers of susceptibility to skin tumor promotion by TPA.	Tetradecanoylphorbol Acetate	273-276	glutathione S-transferase, alpha 4	Mus musculus	13-18
16044405-9	2005	Three genes, Gsta4, Nmes1 (MGC58382), and Serpinb2, located within promotion susceptibility loci Psl1 (chr 9), Psl2 (chr 2), and Psl3 (chr 1), respectively, were identified in this analysis as potential candidates for modifiers of susceptibility to skin tumor promotion by TPA.	Tetradecanoylphorbol Acetate	273-276	serine (or cysteine) peptidase inhibitor, clade B, member 2	Mus musculus	42-50
15994005-4	2006	Immunoblot analysis demonstrated that bicyclol exhibited a remarkable reversing effect on TPA-induced cPKC-alpha and phosphor-ERK1/2 expressions.	Tetradecanoylphorbol Acetate	90-93	mitogen activated protein kinase 3	Rattus norvegicus	126-132
16061224-3	2005	Western blot analysis revealed that conditioned medium from 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated, megakaryocytic differentiating K562 cells upregulated DAB2 expression.	Tetradecanoylphorbol Acetate	60-96	DAB adaptor protein 2	Homo sapiens	166-170
16343552-4	2006	TPA induced an increased expression and activity of the ubiquitin-proteasome pathway, as evidenced by an increased functional activity, and increased expression of the 20S proteasome alpha-subunits, the 19S subunits MSS1 and p42, as well as the ubiquitin conjugating enzyme E2(14k), also with a maximal effect at a concentration of 25 nM and with a 3 h incubation time.	Tetradecanoylphorbol Acetate	0-3	DNA segment, 20S	Mus musculus	168-171
16343552-4	2006	TPA induced an increased expression and activity of the ubiquitin-proteasome pathway, as evidenced by an increased functional activity, and increased expression of the 20S proteasome alpha-subunits, the 19S subunits MSS1 and p42, as well as the ubiquitin conjugating enzyme E2(14k), also with a maximal effect at a concentration of 25 nM and with a 3 h incubation time.	Tetradecanoylphorbol Acetate	0-3	cyclin-dependent kinase 20	Mus musculus	225-228
16224818-4	2005	Recombinant MIF counter-regulated in a dose-dependent fashion dexamethasone inhibition of TNF and IL-8 production by RAW 264.7 macrophages and U-937 promonocytes stimulated with lipopolysaccharides (LPS) or with LPS plus phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	221-252	macrophage migration inhibitory factor	Homo sapiens	12-15
15927450-7	2005	At low concentration of phorbol 12-myristate 13-acetate (PMA), the plasma membrane translocations of the C1a and C1ab mutants are significantly impaired, reflecting an important role of C1a in this process.	Tetradecanoylphorbol Acetate	24-55	endogenous retrovirus group K member 1	Homo sapiens	105-108
15927450-7	2005	At low concentration of phorbol 12-myristate 13-acetate (PMA), the plasma membrane translocations of the C1a and C1ab mutants are significantly impaired, reflecting an important role of C1a in this process.	Tetradecanoylphorbol Acetate	24-55	endogenous retrovirus group K member 1	Homo sapiens	113-116
16651411-9	2006	In the presence of TPA, whereas ERalpha was not bound to the promoter, a strong association of acetylated and/or phospho-H3, MSK1, and c-Jun was observed.	Tetradecanoylphorbol Acetate	19-22	ribosomal protein S6 kinase A5	Homo sapiens	125-129
15927450-7	2005	At low concentration of phorbol 12-myristate 13-acetate (PMA), the plasma membrane translocations of the C1a and C1ab mutants are significantly impaired, reflecting an important role of C1a in this process.	Tetradecanoylphorbol Acetate	57-60	endogenous retrovirus group K member 1	Homo sapiens	105-108
16061224-3	2005	Western blot analysis revealed that conditioned medium from 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated, megakaryocytic differentiating K562 cells upregulated DAB2 expression.	Tetradecanoylphorbol Acetate	98-101	DAB adaptor protein 2	Homo sapiens	166-170
15927450-7	2005	At low concentration of phorbol 12-myristate 13-acetate (PMA), the plasma membrane translocations of the C1a and C1ab mutants are significantly impaired, reflecting an important role of C1a in this process.	Tetradecanoylphorbol Acetate	57-60	endogenous retrovirus group K member 1	Homo sapiens	113-116
16061224-4	2005	DAB2 induction and megakaryocytic differentiation was abrogated when cells were co-treated with the PDGF receptor inhibitor STI571 or when the conditioned medium was derived from TPA-plus STI571-treated cells.	Tetradecanoylphorbol Acetate	179-182	DAB adaptor protein 2	Homo sapiens	0-4
15831706-5	2005	Sema3A dose-dependently inhibited activation of integrin alphaIIbbeta3 by all agonists examined including adenosine diphosphate (ADP), thrombin, convulxin, phorbol 12-myristate 13-acetate, and A23187.	Tetradecanoylphorbol Acetate	156-187	semaphorin 3A	Homo sapiens	0-6
16202869-9	2005	The difference between the current measured during flow of buffer and the ECL co-reactant TPA was three orders of magnitude, indicating that DNA assembled on the surface comprised sufficient ruthenium to generate a measurable signal.	Tetradecanoylphorbol Acetate	90-93	C-C motif chemokine ligand 21	Homo sapiens	74-77
16111532-4	2005	TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64.	Tetradecanoylphorbol Acetate	0-3	integrin subunit alpha X	Homo sapiens	70-75
16111532-4	2005	TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64.	Tetradecanoylphorbol Acetate	0-3	transferrin receptor	Homo sapiens	156-160
15917399-5	2005	Depletion of PKC by phorbol-12-myristate-13-acetate (10 microM) blocked SP-induced IkappaBalpha and p65 phosphorylation and IL-8 production.	Tetradecanoylphorbol Acetate	20-51	protein kinase C delta	Homo sapiens	13-16
15917399-5	2005	Depletion of PKC by phorbol-12-myristate-13-acetate (10 microM) blocked SP-induced IkappaBalpha and p65 phosphorylation and IL-8 production.	Tetradecanoylphorbol Acetate	20-51	RELA proto-oncogene, NF-kB subunit	Homo sapiens	100-103
15975933-3	2005	In U937/PR3, stably transfected with PRCRSV/PR3 to overexpress PR3, PMA-induced p21 expression was significantly decreased as compared with control U937, and this phenomenon was reversed in the presence of the serine proteinase inhibitor, pefabloc.	Tetradecanoylphorbol Acetate	68-71	proteinase 3	Homo sapiens	8-11
15975933-3	2005	In U937/PR3, stably transfected with PRCRSV/PR3 to overexpress PR3, PMA-induced p21 expression was significantly decreased as compared with control U937, and this phenomenon was reversed in the presence of the serine proteinase inhibitor, pefabloc.	Tetradecanoylphorbol Acetate	68-71	proteinase 3	Homo sapiens	44-47
15975933-3	2005	In U937/PR3, stably transfected with PRCRSV/PR3 to overexpress PR3, PMA-induced p21 expression was significantly decreased as compared with control U937, and this phenomenon was reversed in the presence of the serine proteinase inhibitor, pefabloc.	Tetradecanoylphorbol Acetate	68-71	proteinase 3	Homo sapiens	44-47
16061658-5	2005	Stimulation of ErbB-4-expressing cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) results in the proteolytic cleavage of its cytoplasmic domain and translocation of this domain to the nucleus.	Tetradecanoylphorbol Acetate	44-80	erb-b2 receptor tyrosine kinase 4	Homo sapiens	15-21
16061658-5	2005	Stimulation of ErbB-4-expressing cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) results in the proteolytic cleavage of its cytoplasmic domain and translocation of this domain to the nucleus.	Tetradecanoylphorbol Acetate	82-85	erb-b2 receptor tyrosine kinase 4	Homo sapiens	15-21
16061658-7	2005	Coexpression of WWOX and ErbB-4 in HeLa cells followed by treatment with TPA results in the retention of ErbB-4 in the cytoplasm.	Tetradecanoylphorbol Acetate	73-76	erb-b2 receptor tyrosine kinase 4	Homo sapiens	105-111
15916759-4	2005	Activation of neutrophils with PMA, fmet-leu-phe, or TNFalpha known to increase the membrane expression of PR3 did not affect the amount of PR3 in rafts.	Tetradecanoylphorbol Acetate	31-34	proteinase 3	Homo sapiens	107-110
15729714-5	2005	On the other hand, monensin, a Na+/H+ ionophore mimicking NHE activation, and phorbol 12-myristate 13-acetate (PMA), which stimulates NHE, significantly increased the pHi and decreased the drug accumulation in HT29 cells to values similar to those observed in control HT29-dx cells.	Tetradecanoylphorbol Acetate	78-109	solute carrier family 9 member C1	Homo sapiens	134-137
15729714-5	2005	On the other hand, monensin, a Na+/H+ ionophore mimicking NHE activation, and phorbol 12-myristate 13-acetate (PMA), which stimulates NHE, significantly increased the pHi and decreased the drug accumulation in HT29 cells to values similar to those observed in control HT29-dx cells.	Tetradecanoylphorbol Acetate	78-109	glucose-6-phosphate isomerase	Homo sapiens	167-170
15729714-5	2005	On the other hand, monensin, a Na+/H+ ionophore mimicking NHE activation, and phorbol 12-myristate 13-acetate (PMA), which stimulates NHE, significantly increased the pHi and decreased the drug accumulation in HT29 cells to values similar to those observed in control HT29-dx cells.	Tetradecanoylphorbol Acetate	111-114	solute carrier family 9 member C1	Homo sapiens	134-137
15729714-5	2005	On the other hand, monensin, a Na+/H+ ionophore mimicking NHE activation, and phorbol 12-myristate 13-acetate (PMA), which stimulates NHE, significantly increased the pHi and decreased the drug accumulation in HT29 cells to values similar to those observed in control HT29-dx cells.	Tetradecanoylphorbol Acetate	111-114	glucose-6-phosphate isomerase	Homo sapiens	167-170
15824731-5	2005	By using 12-O-tetradecanoylphorbol-13-acetate (TPA), Bryostatin1 and Rottlerin, we show that active PKCdelta is a proproliferative factor in estrogen-dependent breast cancer cells.	Tetradecanoylphorbol Acetate	9-45	protein kinase C delta	Homo sapiens	100-108
15910743-2	2005	AICAR inhibited IL-2 production in Jurkat T cells and peripheral blood lymphocytes activated with PMA plus ionomycin (PMA/Io) or with monoclonal anti-CD3 plus anti-CD28.	Tetradecanoylphorbol Acetate	98-101	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	0-5
15910743-2	2005	AICAR inhibited IL-2 production in Jurkat T cells and peripheral blood lymphocytes activated with PMA plus ionomycin (PMA/Io) or with monoclonal anti-CD3 plus anti-CD28.	Tetradecanoylphorbol Acetate	118-121	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	0-5
15910743-4	2005	We then showed that AICAR inhibited PMA/Io-induced IL-2 mRNA expression and IL-2 promoter activation.	Tetradecanoylphorbol Acetate	36-39	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	20-25
15910743-6	2005	Finally, we found that AICAR inhibited PMA/Io-induced phosphorylation of GSK-3 but not phosphorylation of ERK1/2, p38, and JNK.	Tetradecanoylphorbol Acetate	39-42	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	23-28
15949478-5	2005	METHODS AND RESULTS: Downregulation of PKC by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis, the activation of MAPK, and the expression of c-myc, demonstrating the involvement of PMA-sensitive PKC isoforms in growth factor-induced proliferation and the MAPK pathway.	Tetradecanoylphorbol Acetate	46-77	protein kinase C delta	Homo sapiens	39-42
15949478-5	2005	METHODS AND RESULTS: Downregulation of PKC by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis, the activation of MAPK, and the expression of c-myc, demonstrating the involvement of PMA-sensitive PKC isoforms in growth factor-induced proliferation and the MAPK pathway.	Tetradecanoylphorbol Acetate	46-77	protein kinase C delta	Homo sapiens	222-225
15949478-5	2005	METHODS AND RESULTS: Downregulation of PKC by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis, the activation of MAPK, and the expression of c-myc, demonstrating the involvement of PMA-sensitive PKC isoforms in growth factor-induced proliferation and the MAPK pathway.	Tetradecanoylphorbol Acetate	79-82	protein kinase C delta	Homo sapiens	39-42
15949478-5	2005	METHODS AND RESULTS: Downregulation of PKC by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis, the activation of MAPK, and the expression of c-myc, demonstrating the involvement of PMA-sensitive PKC isoforms in growth factor-induced proliferation and the MAPK pathway.	Tetradecanoylphorbol Acetate	79-82	protein kinase C delta	Homo sapiens	222-225
15889157-5	2005	Stimulation of Jurkat T cells with PMA/ionomycin upregulated the PTHrP P3 promoter by a previously characterized Ets binding site and also induced protein/DNA complex formation identical to that observed in RV-ATL cells.	Tetradecanoylphorbol Acetate	35-38	parathyroid hormone like hormone	Homo sapiens	65-70
15889157-6	2005	Further, we provide evidence that cotransfection with Ets-1 and constitutively active Mek-1 in HTLV-1-negative transformed T cells with stimulation by PMA/ionomycin not only resulted in a robust induction of PTHrP P3 but also formed a complex with ETS-1/P3 EBS similar to that in ATLL cells.	Tetradecanoylphorbol Acetate	151-154	parathyroid hormone like hormone	Homo sapiens	208-213
16342423-8	2005	In H9c2 cells, coincubation with PMA lead to an increase in the rate of the IGF1 receptor activation, and this may further implicate a role for PKC in regulating the IGF1R.	Tetradecanoylphorbol Acetate	33-36	insulin-like growth factor 1 receptor	Rattus norvegicus	76-89
16342423-8	2005	In H9c2 cells, coincubation with PMA lead to an increase in the rate of the IGF1 receptor activation, and this may further implicate a role for PKC in regulating the IGF1R.	Tetradecanoylphorbol Acetate	33-36	insulin-like growth factor 1 receptor	Rattus norvegicus	166-171
15878157-9	2005	TPA-induced activation of ERK and PKCdelta was dependent on the expression of EGFR although the intrinsic kinase activity of EGFR was not required.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	34-42
15878157-10	2005	In contrast, TPA-induced phosphorylation of p38 MAPK, JNKs and other PKC isoforms was independent of EGFR.	Tetradecanoylphorbol Acetate	13-16	protein kinase C delta	Homo sapiens	69-72
15878157-11	2005	Ethanol selectively inhibited TPA-induced phosphorylation of ERK and PKCdelta, and modestly suppressed TPA-stimulated AP-1 activation in B82L and B82M721 cells.	Tetradecanoylphorbol Acetate	30-33	protein kinase C delta	Homo sapiens	69-77
15689183-2	2005	In the present study, we found that PMA activates cPLA2 by a Rac-p38 kinase-dependent pathway.	Tetradecanoylphorbol Acetate	36-39	mitogen activated protein kinase 14	Rattus norvegicus	65-68
15689183-4	2005	In another experiment to understand the signalling mechanism by which the Rac-p38 kinase cascade mediates cPLA2 activation in response to PMA, we observed that PMA-induced cPLA2 translocation to the perinuclear region is completely inhibited by the expression of Rac1N17 or treatment with SB203580 (inhibitor of p38 kinase), suggesting that Rac-p38 kinase cascade acts in this instance by mediating the translocation of cPLA2.	Tetradecanoylphorbol Acetate	138-141	mitogen activated protein kinase 14	Rattus norvegicus	78-81
15922088-8	2005	The TPA-induced phosphorylations of Raf-1, MEK1/2 and p44/p42 MAP kinase were inhibited by tiludronate.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase kinase 1	Mus musculus	43-49
15922088-8	2005	The TPA-induced phosphorylations of Raf-1, MEK1/2 and p44/p42 MAP kinase were inhibited by tiludronate.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase 3	Mus musculus	54-57
15922088-8	2005	The TPA-induced phosphorylations of Raf-1, MEK1/2 and p44/p42 MAP kinase were inhibited by tiludronate.	Tetradecanoylphorbol Acetate	4-7	cyclin-dependent kinase 20	Mus musculus	58-61
15878350-8	2005	In co-transfection/co-precipitation studies, PMA treatment stimulated EBP50 oligomerization.	Tetradecanoylphorbol Acetate	45-48	SLC9A3 regulator 1	Homo sapiens	70-75
15625302-1	2005	We have previously demonstrated that constant 20 mmHg extracellular pressure increases serum-opsonized latex bead phagocytosis by phorbol 12-myristate 13-acetate (PMA)- differentiated THP-1 macrophages in part by inhibiting focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	163-166	protein tyrosine kinase 2	Homo sapiens	224-245
15625302-1	2005	We have previously demonstrated that constant 20 mmHg extracellular pressure increases serum-opsonized latex bead phagocytosis by phorbol 12-myristate 13-acetate (PMA)- differentiated THP-1 macrophages in part by inhibiting focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	163-166	protein tyrosine kinase 2	Homo sapiens	247-250
15862717-4	2005	Our recent studies demonstrated that overexpression of MnSOD reduced tumor incidence in the two-stage 7,12-dimethylbenz(a)-anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) skin carcinogenesis model.	Tetradecanoylphorbol Acetate	141-177	superoxide dismutase 2	Homo sapiens	55-60
15862717-4	2005	Our recent studies demonstrated that overexpression of MnSOD reduced tumor incidence in the two-stage 7,12-dimethylbenz(a)-anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) skin carcinogenesis model.	Tetradecanoylphorbol Acetate	179-182	superoxide dismutase 2	Homo sapiens	55-60
15808414-7	2005	When tested in an ex vivo whole-blood stimulation system using PMA/Ionomycin the intracellular MIF content doubled in CD3+ T-lymphocytes and increased threefold in CD14+ macrophages.	Tetradecanoylphorbol Acetate	63-66	macrophage migration inhibitory factor	Homo sapiens	95-98
15808414-7	2005	When tested in an ex vivo whole-blood stimulation system using PMA/Ionomycin the intracellular MIF content doubled in CD3+ T-lymphocytes and increased threefold in CD14+ macrophages.	Tetradecanoylphorbol Acetate	63-66	CD14 molecule	Homo sapiens	164-168
15826073-5	2005	Pretreatment of JB6 P+ mouse epidermal cells with lingonberry extracts produced a dose-dependent inhibition on the activation of activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) induced by either 12-O-tetradecanoylphorbol-13-acetate (TPA) or ultraviolet-B (UVB).	Tetradecanoylphorbol Acetate	212-248	jun proto-oncogene	Mus musculus	129-148
15826073-5	2005	Pretreatment of JB6 P+ mouse epidermal cells with lingonberry extracts produced a dose-dependent inhibition on the activation of activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) induced by either 12-O-tetradecanoylphorbol-13-acetate (TPA) or ultraviolet-B (UVB).	Tetradecanoylphorbol Acetate	212-248	jun proto-oncogene	Mus musculus	150-154
15826073-5	2005	Pretreatment of JB6 P+ mouse epidermal cells with lingonberry extracts produced a dose-dependent inhibition on the activation of activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) induced by either 12-O-tetradecanoylphorbol-13-acetate (TPA) or ultraviolet-B (UVB).	Tetradecanoylphorbol Acetate	250-253	jun proto-oncogene	Mus musculus	129-148
15826073-5	2005	Pretreatment of JB6 P+ mouse epidermal cells with lingonberry extracts produced a dose-dependent inhibition on the activation of activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) induced by either 12-O-tetradecanoylphorbol-13-acetate (TPA) or ultraviolet-B (UVB).	Tetradecanoylphorbol Acetate	250-253	jun proto-oncogene	Mus musculus	150-154
16614396-6	2006	The levels of COX-2 expression induced in mouse skin after 4-h treatment with topical TPA (10 nmol) was also diminished significantly by pretreating CP (40 or 200 mg/kg) for 30 min.	Tetradecanoylphorbol Acetate	86-89	cytochrome c oxidase II, mitochondrial	Mus musculus	14-19
16614396-8	2006	Moreover, phosphorylation of p38 mitogen-activated protein kinase in ICR mouse skin, measured 4 h after TPA treatment, was suppressed by oral pretreatment of CP (40 or 200 mg/kg).	Tetradecanoylphorbol Acetate	104-107	mitogen-activated protein kinase 14	Mus musculus	29-32
16328454-6	2006	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) mimicked the effects of m1 receptor activation by inhibiting Kir2.1 currents.	Tetradecanoylphorbol Acetate	31-62	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	130-136
16328454-6	2006	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) mimicked the effects of m1 receptor activation by inhibiting Kir2.1 currents.	Tetradecanoylphorbol Acetate	64-67	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	130-136
16365892-6	2006	Similar to PGF2alpha, phorbol 12-myristate 13-acetate (PMA) also increased importin beta protein.	Tetradecanoylphorbol Acetate	22-53	karyopherin subunit beta 1	Rattus norvegicus	75-88
16365892-6	2006	Similar to PGF2alpha, phorbol 12-myristate 13-acetate (PMA) also increased importin beta protein.	Tetradecanoylphorbol Acetate	55-58	karyopherin subunit beta 1	Rattus norvegicus	75-88
16480936-6	2006	In the process of Glu-Plasminogen activation, we found an increase in plasmin generation both at fibrin and cellular surface level as a function of the concentration of beta2GPI added, suggesting an important role as a cofactor in the trimolecular complex beta2GPI-Plasminogen-tPA.	Tetradecanoylphorbol Acetate	277-280	plasminogen	Homo sapiens	70-77
16374778-6	2006	PMA, which mimics diacylglycerol (DAG) as an activator of cPKC, novel-PKC (nPKC), and non-PKC DAG-driven molecule(s), produced a dose-dependent dual effect on phagocytosis by CR3/MAC-1 and SRAI/II, i.e., augmentation at low concentrations and inhibition at high concentrations.	Tetradecanoylphorbol Acetate	0-3	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	175-178
16374778-7	2006	Inhibition of phagocytosis by CR3/MAC-1 was enhanced by combining inhibiting concentrations of PMA with PKC inhibitors Go-6976 or Ro-318220, suggesting inhibition by PMA/DAG-driven non-PKC molecule(s).	Tetradecanoylphorbol Acetate	95-98	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	30-33
16525710-10	2006	The administration of 12-O-tetradecanoyl phorbol 13-acetate also induced changes in the sub-cellular localization of beta2-chimaerin, which was not affected by a presence of the PKC inhibitor (GF109203X).	Tetradecanoylphorbol Acetate	22-59	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	117-122
16646678-3	2006	In NPA cells, activation of wild-type (WT) PKCdelta with phorbol 12-myristate 13-acetate (PMA) induced an arrest in cell growth at G(1) phase, which was itself inhibited by the PKCdelta inhibitor rottlerin.	Tetradecanoylphorbol Acetate	57-88	protein kinase C delta	Homo sapiens	43-51
16646678-3	2006	In NPA cells, activation of wild-type (WT) PKCdelta with phorbol 12-myristate 13-acetate (PMA) induced an arrest in cell growth at G(1) phase, which was itself inhibited by the PKCdelta inhibitor rottlerin.	Tetradecanoylphorbol Acetate	57-88	protein kinase C delta	Homo sapiens	177-185
16646678-3	2006	In NPA cells, activation of wild-type (WT) PKCdelta with phorbol 12-myristate 13-acetate (PMA) induced an arrest in cell growth at G(1) phase, which was itself inhibited by the PKCdelta inhibitor rottlerin.	Tetradecanoylphorbol Acetate	90-93	protein kinase C delta	Homo sapiens	43-51
16646678-3	2006	In NPA cells, activation of wild-type (WT) PKCdelta with phorbol 12-myristate 13-acetate (PMA) induced an arrest in cell growth at G(1) phase, which was itself inhibited by the PKCdelta inhibitor rottlerin.	Tetradecanoylphorbol Acetate	90-93	protein kinase C delta	Homo sapiens	177-185
16529737-7	2006	Bradykinin transiently activated the p42/p44 MAP kinase pathway, whereas PMA-induced activation of p42/p44 mitogen activated protein (MAP) kinase was sustained.	Tetradecanoylphorbol Acetate	73-76	erythrocyte membrane protein band 4.2	Bos taurus	99-102
16596993-3	2006	Additionally, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC activity decreased significantly in cells exposed to the extract in concentrations of 160 microg/mL (p&lt;0.05), 200 microg/mL (p&lt;0.005), and 240 microg/mL (p&lt;0.005).	Tetradecanoylphorbol Acetate	14-50	ornithine decarboxylase 1	Homo sapiens	65-68
16596993-3	2006	Additionally, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC activity decreased significantly in cells exposed to the extract in concentrations of 160 microg/mL (p&lt;0.05), 200 microg/mL (p&lt;0.005), and 240 microg/mL (p&lt;0.005).	Tetradecanoylphorbol Acetate	52-55	ornithine decarboxylase 1	Homo sapiens	65-68
16510590-6	2006	ERK1(-/-) mice are resistant to development of skin papillomas induced by 7,12-dimethylbenz(a)anthracene (DMBA) and promoted by TPA.	Tetradecanoylphorbol Acetate	128-131	mitogen-activated protein kinase 3	Mus musculus	0-4
16455237-4	2006	Conversely, PMA induced a marked increase of MT1-MMP and MMP-9.	Tetradecanoylphorbol Acetate	12-15	matrix metallopeptidase 14	Homo sapiens	45-52
16449321-9	2006	Using in vitro matrix degradation assays, we demonstrated that PMA-induced podosomes are endowed with proteolytic activities involving MT1-MMP-mediated activation of MMP2.	Tetradecanoylphorbol Acetate	63-66	matrix metallopeptidase 14	Homo sapiens	135-142
16449321-9	2006	Using in vitro matrix degradation assays, we demonstrated that PMA-induced podosomes are endowed with proteolytic activities involving MT1-MMP-mediated activation of MMP2.	Tetradecanoylphorbol Acetate	63-66	matrix metallopeptidase 2	Homo sapiens	166-170
16373364-11	2006	Ets1 binding to the proximal promoter region, demonstrated by chromatin immunoprecipitation, was stimulated by PMA/cAMP.	Tetradecanoylphorbol Acetate	111-114	E26 avian leukemia oncogene 1, 5' domain	Mus musculus	0-4
16534736-1	2006	We studied the inhibitory effects of ginsenoside-Rb1 (1) on 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced transcriptional activation of the cyclooxygenase-2 (COX-2) promoter.	Tetradecanoylphorbol Acetate	98-101	RB transcriptional corepressor 1	Homo sapiens	49-52
16534736-3	2006	Ginsenoside-Rb1 at 100 microM inhibited TPA-induced transcriptional activation of the COX-2 promoter.	Tetradecanoylphorbol Acetate	40-43	RB transcriptional corepressor 1	Homo sapiens	12-15
16534736-7	2006	In conclusion, ginsenoside-Rb1 inhibits TPA-induced COX-2 promoter activity through the nuclear factor interleukin-6 binding site and not through the nuclear factor-kappaB or cAMP-responsive elements.	Tetradecanoylphorbol Acetate	40-43	RB transcriptional corepressor 1	Homo sapiens	27-30
16143405-7	2006	Upon activation with PMA and ionomycin, the purified CD4+CCR4+ T lymphocytes produced IL-4 and no IFN-gamma.	Tetradecanoylphorbol Acetate	21-24	C-C motif chemokine receptor 4	Homo sapiens	57-61
19771276-9	2006	Pretreatment with celecoxib attenuated DNA binding of transcription factor (C/EBP) in the TPA-stimulated mouse skin.	Tetradecanoylphorbol Acetate	90-93	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	18-74
19771276-9	2006	Pretreatment with celecoxib attenuated DNA binding of transcription factor (C/EBP) in the TPA-stimulated mouse skin.	Tetradecanoylphorbol Acetate	90-93	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	76-81
16716806-0	2006	Se-methylselenocysteine enhances PMA-mediated CD11c expression via phospholipase D1 activation in U937 cells.	Tetradecanoylphorbol Acetate	33-36	integrin subunit alpha X	Homo sapiens	46-51
16716806-3	2006	During phorbol myristate acetate (PMA)-induced differentiation of U937 cells, we found that the mRNA expression of CD11c was increased.	Tetradecanoylphorbol Acetate	7-32	integrin subunit alpha X	Homo sapiens	115-120
16716806-3	2006	During phorbol myristate acetate (PMA)-induced differentiation of U937 cells, we found that the mRNA expression of CD11c was increased.	Tetradecanoylphorbol Acetate	34-37	integrin subunit alpha X	Homo sapiens	115-120
16601352-10	2006	The incubation of purified basophils with A23187 plus PMA significantly enhanced CD40 ligand expression, and the presence of luteolin again had an inhibitory effect.	Tetradecanoylphorbol Acetate	54-57	CD40 molecule	Homo sapiens	81-85
16365389-4	2006	Furthermore, tissue-specific junB knockout mice respond to 12-O-tetradecanoyl-phorbol-13-acetate, a potent AP-1 activator, with markedly increased and sustained epidermal RAE-1epsilon expression.	Tetradecanoylphorbol Acetate	59-96	jun proto-oncogene	Mus musculus	107-111
16720925-11	2006	All the inhibitors tested without and with PMA showed a dose-dependent decrease in both MMP-2 and -9 expression.	Tetradecanoylphorbol Acetate	43-46	matrix metallopeptidase 2	Homo sapiens	88-100
16339753-4	2005	Flow cytometry analysis of CD61 indicated that phorbol myristate acetate (PMA) (16 nM) stimulated megakaryocytic commitment of K562 cells was increased (3- to 4-fold) following exposure to Tat (1-100 ng/ml).	Tetradecanoylphorbol Acetate	47-72	tyrosine aminotransferase	Homo sapiens	189-192
16339753-4	2005	Flow cytometry analysis of CD61 indicated that phorbol myristate acetate (PMA) (16 nM) stimulated megakaryocytic commitment of K562 cells was increased (3- to 4-fold) following exposure to Tat (1-100 ng/ml).	Tetradecanoylphorbol Acetate	74-77	tyrosine aminotransferase	Homo sapiens	189-192
16265694-8	2005	PD-1-positive SS salivary lymphocytes expressed IL-10 intracellularly upon PMA/ionomycin stimulation.	Tetradecanoylphorbol Acetate	75-78	programmed cell death 1	Homo sapiens	0-4
16192383-6	2005	Similar camphor-activated TRPV1-like currents were observed in isolated rat DRG neurons and were strongly potentiated after activation of protein kinase C with phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	160-191	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-31
16156648-5	2005	We found that replacing syndecan-1 juxtamembrane amino acid residues A243-S-Q-S-L247 with human CD4 amino acid residues can completely block PMA-induced syndecan-1 ectodomain shedding.	Tetradecanoylphorbol Acetate	141-144	syndecan 1	Homo sapiens	24-34
16156648-5	2005	We found that replacing syndecan-1 juxtamembrane amino acid residues A243-S-Q-S-L247 with human CD4 amino acid residues can completely block PMA-induced syndecan-1 ectodomain shedding.	Tetradecanoylphorbol Acetate	141-144	syndecan 1	Mus musculus	153-163
16156648-6	2005	Furthermore, using liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS), we identified the proteolytic cleavage site of syndecan-1 as amino acids A243 and S244, generated by constitutive and PMA-induced shedding from murine NMuMG cells.	Tetradecanoylphorbol Acetate	214-217	syndecan 1	Mus musculus	143-153
16005434-2	2005	Hormones and phorbol esters (PMA) inhibit NPR-B in calcium and protein kinase c-dependent manners, respectively.	Tetradecanoylphorbol Acetate	29-32	natriuretic peptide receptor 2	Homo sapiens	42-47
16156860-8	2005	Sustained CDK2 catalytic activity, typically associated with megakaryocyte endomitosis, was dramatically decreased in TPA-stimulated Evi1-expressing HEL cells because of significantly reduced levels of cyclin A.	Tetradecanoylphorbol Acetate	118-121	cyclin dependent kinase 2	Homo sapiens	10-14
16259378-5	2005	Mg2+ efflux in KCl medium by K+/Mg2+ antiport via the unspecific choline exchanger was not significantly reduced in SHR and was equally affected by PMA and staurosporine in WKY and SHR.	Tetradecanoylphorbol Acetate	148-151	mucin 7, secreted	Homo sapiens	0-3
16099101-4	2005	injection of PMA (16-1600 pmol/paw), but not its inactive analogue alpha-PMA, produced a long-lasting overt nociception (up to 45 min), as well as the activation of PKCalpha and PKCepsilon isoforms in treated paws.	Tetradecanoylphorbol Acetate	13-16	protein kinase C, epsilon	Mus musculus	178-188
15861394-8	2005	Further, inhibition of the AP-1 transcriptional complex by [6]-Gingerol, or by the ectopic expression of JDP2, blocked TGF-beta1-induced EMT and conversely, stimulation of AP-1 by 12-O-tetradecanoylphorbol 13-acetate (TPA) substituted for EGF in the induction of EMT by TGF-beta1 in cells containing normal Ras.	Tetradecanoylphorbol Acetate	180-216	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-31
15861394-8	2005	Further, inhibition of the AP-1 transcriptional complex by [6]-Gingerol, or by the ectopic expression of JDP2, blocked TGF-beta1-induced EMT and conversely, stimulation of AP-1 by 12-O-tetradecanoylphorbol 13-acetate (TPA) substituted for EGF in the induction of EMT by TGF-beta1 in cells containing normal Ras.	Tetradecanoylphorbol Acetate	180-216	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-176
15861394-8	2005	Further, inhibition of the AP-1 transcriptional complex by [6]-Gingerol, or by the ectopic expression of JDP2, blocked TGF-beta1-induced EMT and conversely, stimulation of AP-1 by 12-O-tetradecanoylphorbol 13-acetate (TPA) substituted for EGF in the induction of EMT by TGF-beta1 in cells containing normal Ras.	Tetradecanoylphorbol Acetate	218-221	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-31
15861394-9	2005	The presence of oncogenic Ras, the treatment of cells with EGF, or the treatment of cells with TPA to activate AP-1, potentiated TGF-beta1-induced Smad-dependent transcription, an effect that was attenuated by the inhibition of MAPKs and AP-1.	Tetradecanoylphorbol Acetate	95-98	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	111-115
15861394-9	2005	The presence of oncogenic Ras, the treatment of cells with EGF, or the treatment of cells with TPA to activate AP-1, potentiated TGF-beta1-induced Smad-dependent transcription, an effect that was attenuated by the inhibition of MAPKs and AP-1.	Tetradecanoylphorbol Acetate	95-98	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	238-242
15917220-4	2005	FBI-1 enhanced NF-kappaB-mediated transcription of E-selectin genes in HeLa cells upon phorbol 12-myristate 13-acetate stimulation and overcame gene repression by IkappaB alpha or IkappaB beta.	Tetradecanoylphorbol Acetate	87-118	zinc finger and BTB domain containing 7A	Homo sapiens	0-5
15824731-5	2005	By using 12-O-tetradecanoylphorbol-13-acetate (TPA), Bryostatin1 and Rottlerin, we show that active PKCdelta is a proproliferative factor in estrogen-dependent breast cancer cells.	Tetradecanoylphorbol Acetate	47-50	protein kinase C delta	Homo sapiens	100-108
15824731-6	2005	Furthermore, activation of PKCdelta by TPA resulted in activation and nuclear translocation of ERalpha and in an increase of ER-dependent reporter gene expression.	Tetradecanoylphorbol Acetate	39-42	protein kinase C delta	Homo sapiens	27-35
15824731-7	2005	Transfection and expression of the regulatory domain RDdelta of PKCdelta, which is inhibitory to PKCdelta, inhibited the TPA-induced ERalpha activation and translocation.	Tetradecanoylphorbol Acetate	121-124	protein kinase C delta	Homo sapiens	64-72
15824731-7	2005	Transfection and expression of the regulatory domain RDdelta of PKCdelta, which is inhibitory to PKCdelta, inhibited the TPA-induced ERalpha activation and translocation.	Tetradecanoylphorbol Acetate	121-124	protein kinase C delta	Homo sapiens	97-105
15972968-5	2005	Moreover, dexamethasone, which is a potent inhibitor of AP-1-mediated transactivation that exhibits anti-inflammatory and anti-tumor promoting activities, inhibited TPA-induced expression of Rab11a.	Tetradecanoylphorbol Acetate	165-168	jun proto-oncogene	Mus musculus	56-60
15785969-6	2005	The expression of a large fraction of the 80 EBV genes was found to be activated after TPA treatment with a noticeable increase of 19 and 21 fold, respectively in BSLF1 and BBLF4.	Tetradecanoylphorbol Acetate	87-90	helicase-primase helicase subunit	Human gammaherpesvirus 4	173-178
15790882-10	2005	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element.	Tetradecanoylphorbol Acetate	15-51	inversin	Homo sapiens	99-103
15790882-10	2005	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element.	Tetradecanoylphorbol Acetate	15-51	inversin	Homo sapiens	206-210
15790882-10	2005	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element.	Tetradecanoylphorbol Acetate	53-56	inversin	Homo sapiens	99-103
15790882-10	2005	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element.	Tetradecanoylphorbol Acetate	53-56	inversin	Homo sapiens	206-210
15777839-4	2005	Cholera toxin-induced activation of cAMP responsive element (CRE)-binding protein (CREB) was enhanced by pretreating cells with ATRA for 24 h. In contrast, HGF production induced by epidermal growth factor (EGF) or phorbol 12-myristate 13-acetate (PMA) was potently inhibited by ATRA.	Tetradecanoylphorbol Acetate	215-246	hepatocyte growth factor	Homo sapiens	156-159
15777839-4	2005	Cholera toxin-induced activation of cAMP responsive element (CRE)-binding protein (CREB) was enhanced by pretreating cells with ATRA for 24 h. In contrast, HGF production induced by epidermal growth factor (EGF) or phorbol 12-myristate 13-acetate (PMA) was potently inhibited by ATRA.	Tetradecanoylphorbol Acetate	248-251	hepatocyte growth factor	Homo sapiens	156-159
15972968-6	2005	Within the Rab11a gene promoter, we identified a functional AP-1 binding element that exhibited elevated c-Fos binding activity after TPA treatment of keratinocytes.	Tetradecanoylphorbol Acetate	134-137	jun proto-oncogene	Mus musculus	60-64
15840578-0	2005	Role of alpha1 2.3 subunit I-II linker sites in the enhancement of Ca(v) 2.3 current by phorbol 12-myristate 13-acetate and acetyl-beta-methylcholine.	Tetradecanoylphorbol Acetate	88-119	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	67-76
15622522-6	2005	TPA induced loss of function concomitant with a dislocation of ZO-1 and occludin could be prevented by inhibition of MEK1 by PD98059.	Tetradecanoylphorbol Acetate	0-3	occludin	Homo sapiens	72-80
15632134-6	2005	The activity of PKCalpha and downstream signaling kinases is enhanced, and expression of cyclooxygenase-2 (COX-2) is significantly greater, in PPARbeta-null mouse skin in response to TPA compared with wild-type mouse skin.	Tetradecanoylphorbol Acetate	183-186	prostaglandin-endoperoxide synthase 2	Mus musculus	89-105
15632134-6	2005	The activity of PKCalpha and downstream signaling kinases is enhanced, and expression of cyclooxygenase-2 (COX-2) is significantly greater, in PPARbeta-null mouse skin in response to TPA compared with wild-type mouse skin.	Tetradecanoylphorbol Acetate	183-186	prostaglandin-endoperoxide synthase 2	Mus musculus	107-112
15632134-7	2005	Inhibition of PKCalpha or COX-2 reduced cell proliferation in TPA-treated PPARbeta-null keratinocytes in a dose-dependent manner, whereas it only slightly influenced cell proliferation in wild-type keratinocytes.	Tetradecanoylphorbol Acetate	62-65	prostaglandin-endoperoxide synthase 2	Mus musculus	26-31
15618223-5	2005	PMA-induced phosphorylation of the EGFR at Tyr(1068) was blocked by bisindolylmaleimide (BIM), a PKC inhibitor, and rottlerin, a PKCdelta-specific inhibitor.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	97-100
15618223-5	2005	PMA-induced phosphorylation of the EGFR at Tyr(1068) was blocked by bisindolylmaleimide (BIM), a PKC inhibitor, and rottlerin, a PKCdelta-specific inhibitor.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	129-137
15811935-9	2005	Treatment of cells with the protein kinase C activator 12-O-tetradecanoylphorbol-13-acetate increased the phosphorylated species of Cx43 and correspondingly inhibited GJIC.	Tetradecanoylphorbol Acetate	55-91	gap junction protein alpha 1	Homo sapiens	132-136
16117614-5	2005	To explain the apoptotic effects of SNL glycoprotein, we investigated its effects on 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated protein kinase C (PKC) alpha activity and DNA-binding activity of nuclear factor (NF) kappaB in HT-29 cells, using western blot analysis and electrophoretic mobility shift assays.	Tetradecanoylphorbol Acetate	85-121	fascin actin-bundling protein 1	Homo sapiens	36-39
16117614-5	2005	To explain the apoptotic effects of SNL glycoprotein, we investigated its effects on 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated protein kinase C (PKC) alpha activity and DNA-binding activity of nuclear factor (NF) kappaB in HT-29 cells, using western blot analysis and electrophoretic mobility shift assays.	Tetradecanoylphorbol Acetate	123-126	fascin actin-bundling protein 1	Homo sapiens	36-39
16117614-6	2005	Results from these experiments showed that SNL glycoprotein has remarkable inhibitory effects on the activities of TPA (100 nM)-stimulated PKCalpha and NF-kappaB in HT-29 cells.	Tetradecanoylphorbol Acetate	115-118	fascin actin-bundling protein 1	Homo sapiens	43-46
15840578-1	2005	Potentiation of Ca(v) 2.3 currents by phorbol 12-myristate 13-acetate (PMA) or acetyl-beta-methylcholine (MCh) may be due to protein kinase C (PKC)-mediated phosphorylation of the alpha1 2.3 subunit.	Tetradecanoylphorbol Acetate	38-69	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	16-25
15840578-1	2005	Potentiation of Ca(v) 2.3 currents by phorbol 12-myristate 13-acetate (PMA) or acetyl-beta-methylcholine (MCh) may be due to protein kinase C (PKC)-mediated phosphorylation of the alpha1 2.3 subunit.	Tetradecanoylphorbol Acetate	71-74	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	16-25
15824103-2	2005	The activity of other Nox enzymes such as gp91(phox)/Nox2 and Nox1 is known to absolutely require both an organizer protein (p47(phox) or Noxo1) andanactivatorprotein (p67(phox) or Noxa1); for the p47(phox)-dependent activation of these oxidases, treatment of cells with stimulants such as phorbol 12-myristate 13-acetate is also indispensable.	Tetradecanoylphorbol Acetate	290-321	cytochrome b-245, beta polypeptide	Mus musculus	53-57
15924239-8	2005	The protein kinase C activator phorbol 12-myristate 13-acetate and the cAMP-elevating compounds forskolin/3-isobutyl-1-methylxanthine, 8-Br-cAMP and PGE2 stimulated TRPV5 activity in GFP-TRPV5-MDCK cells by 121+/-7, 79+/-5, 55+/-4 and 61+/-7%, respectively.	Tetradecanoylphorbol Acetate	31-62	transient receptor potential cation channel subfamily V member 5	Canis lupus familiaris	165-170
15924239-8	2005	The protein kinase C activator phorbol 12-myristate 13-acetate and the cAMP-elevating compounds forskolin/3-isobutyl-1-methylxanthine, 8-Br-cAMP and PGE2 stimulated TRPV5 activity in GFP-TRPV5-MDCK cells by 121+/-7, 79+/-5, 55+/-4 and 61+/-7%, respectively.	Tetradecanoylphorbol Acetate	31-62	transient receptor potential cation channel subfamily V member 5	Canis lupus familiaris	187-192
15649406-1	2005	The effects of activating endogenous protein kinase C (PKC) on cell proliferation and the cell cycle were investigated by treating the breast cancer cell line SKBR-3 with phorbol 12-myristate 13 acetate (PMA).	Tetradecanoylphorbol Acetate	171-202	protein kinase C delta	Homo sapiens	55-58
15824103-2	2005	The activity of other Nox enzymes such as gp91(phox)/Nox2 and Nox1 is known to absolutely require both an organizer protein (p47(phox) or Noxo1) andanactivatorprotein (p67(phox) or Noxa1); for the p47(phox)-dependent activation of these oxidases, treatment of cells with stimulants such as phorbol 12-myristate 13-acetate is also indispensable.	Tetradecanoylphorbol Acetate	290-321	NADPH oxidase 1	Mus musculus	62-66
15649406-1	2005	The effects of activating endogenous protein kinase C (PKC) on cell proliferation and the cell cycle were investigated by treating the breast cancer cell line SKBR-3 with phorbol 12-myristate 13 acetate (PMA).	Tetradecanoylphorbol Acetate	204-207	protein kinase C delta	Homo sapiens	55-58
15843397-5	2005	In addition, we observed haplotypic variation in response to dibutyl cyclic AMP and tetradecanoyl phorbol acetate that enhances the levels of SDF-1 transcripts probably through activation of transcription factors.	Tetradecanoylphorbol Acetate	84-113	C-X-C motif chemokine ligand 12	Homo sapiens	142-147
15649406-6	2005	Downstream of PKC, PMA treatment inhibited extracellular signal-regulated kinase mitogen-activated protein kinase phosphorylation, up-regulated c-jun NH(2)-terminal kinase phosphorylation, and inhibited retinoblastoma (Rb) phosphorylation.	Tetradecanoylphorbol Acetate	19-22	protein kinase C delta	Homo sapiens	14-17
15649406-6	2005	Downstream of PKC, PMA treatment inhibited extracellular signal-regulated kinase mitogen-activated protein kinase phosphorylation, up-regulated c-jun NH(2)-terminal kinase phosphorylation, and inhibited retinoblastoma (Rb) phosphorylation.	Tetradecanoylphorbol Acetate	19-22	RB transcriptional corepressor 1	Homo sapiens	203-217
15649406-6	2005	Downstream of PKC, PMA treatment inhibited extracellular signal-regulated kinase mitogen-activated protein kinase phosphorylation, up-regulated c-jun NH(2)-terminal kinase phosphorylation, and inhibited retinoblastoma (Rb) phosphorylation.	Tetradecanoylphorbol Acetate	19-22	RB transcriptional corepressor 1	Homo sapiens	219-221
15738002-8	2005	Salicylate inhibited RSK in vivo and blocked the activity of RSK2 purified from cells stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	100-131	ribosomal protein S6 kinase A3	Homo sapiens	61-65
15738002-8	2005	Salicylate inhibited RSK in vivo and blocked the activity of RSK2 purified from cells stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	133-136	ribosomal protein S6 kinase A3	Homo sapiens	61-65
15738002-9	2005	Mutation of the RSK-phosphorylation site (T266A) of C/EBPbeta abrogated PMA-stimulated C/EBPbeta binding activity.	Tetradecanoylphorbol Acetate	72-75	ribosomal protein S6 kinase A3	Homo sapiens	16-19
15738002-9	2005	Mutation of the RSK-phosphorylation site (T266A) of C/EBPbeta abrogated PMA-stimulated C/EBPbeta binding activity.	Tetradecanoylphorbol Acetate	72-75	CCAAT enhancer binding protein beta	Homo sapiens	52-61
15738002-9	2005	Mutation of the RSK-phosphorylation site (T266A) of C/EBPbeta abrogated PMA-stimulated C/EBPbeta binding activity.	Tetradecanoylphorbol Acetate	72-75	CCAAT enhancer binding protein beta	Homo sapiens	87-96
15743775-9	2005	Stimulation of TE671 cells with 12-O-tetradecanoylphorbol-13-acetate or transfection with protein kinase Calpha expression vector induced phosphorylation of Hes-1, inhibition of DNA binding of Hes-1 to the N-box, and activation of the AP-2beta function to up-regulate L-PGDS gene expression.	Tetradecanoylphorbol Acetate	32-68	hes family bHLH transcription factor 1	Homo sapiens	157-162
15634742-4	2005	Exposure of mCT12 cells to EGF, ATP, PMA, and DBHQ caused an increase in phosphorylation of p42/p44 (extracellular signal-regulated kinase; ERK1/2).	Tetradecanoylphorbol Acetate	37-40	cyclin-dependent kinase 20	Mus musculus	92-95
15634742-4	2005	Exposure of mCT12 cells to EGF, ATP, PMA, and DBHQ caused an increase in phosphorylation of p42/p44 (extracellular signal-regulated kinase; ERK1/2).	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 3	Mus musculus	96-99
15455341-8	2005	We also found that topical application of PFE resulted in inhibition of TPA-induced phosphorylation of ERK1/2, p38 and JNK1/2, as well as activation of NF-kappaB and IKKalpha and phosphorylation and degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 3	Mus musculus	103-109
15455341-8	2005	We also found that topical application of PFE resulted in inhibition of TPA-induced phosphorylation of ERK1/2, p38 and JNK1/2, as well as activation of NF-kappaB and IKKalpha and phosphorylation and degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 14	Mus musculus	111-114
15634742-4	2005	Exposure of mCT12 cells to EGF, ATP, PMA, and DBHQ caused an increase in phosphorylation of p42/p44 (extracellular signal-regulated kinase; ERK1/2).	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase 3	Mus musculus	140-146
15916720-6	2005	The Phosphoinositide-3-kinase (PI3K)-specific inhibitor Wortmannin inhibited the upregulation of these markers whereas 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced a rapid and FceRI-independent upregulation within 1-2 min.	Tetradecanoylphorbol Acetate	119-156	Fc epsilon receptor Ia	Homo sapiens	183-188
15743775-9	2005	Stimulation of TE671 cells with 12-O-tetradecanoylphorbol-13-acetate or transfection with protein kinase Calpha expression vector induced phosphorylation of Hes-1, inhibition of DNA binding of Hes-1 to the N-box, and activation of the AP-2beta function to up-regulate L-PGDS gene expression.	Tetradecanoylphorbol Acetate	32-68	hes family bHLH transcription factor 1	Homo sapiens	193-198
15802798-3	2005	UDCA did not induce HGF production in human dermal fibroblasts, but it potently inhibited phorbol-12-myristate-13-acetate (PMA)- and cholera-toxin-induced HGF production without affecting cell viability.	Tetradecanoylphorbol Acetate	90-121	hepatocyte growth factor	Homo sapiens	155-158
15836772-0	2005	Recruitment of E-cadherin associated with alpha- and beta-catenins and p120ctn to the nectin-based cell-cell adhesion sites by the action of 12-O-tetradecanoylphorbol-13-acetate in MDCK cells.	Tetradecanoylphorbol Acetate	141-177	cadherin 1	Canis lupus familiaris	15-25
15640347-8	2005	Furthermore, the PKCdelta/PKC inhibitor rottlerin prevented the effects induced by phorbol 12-myristate 13-acetate and human neutrophil elastase, suggesting that PKCdelta and PKC are involved in Duox1 activation.	Tetradecanoylphorbol Acetate	83-114	protein kinase C delta	Homo sapiens	17-25
15640347-8	2005	Furthermore, the PKCdelta/PKC inhibitor rottlerin prevented the effects induced by phorbol 12-myristate 13-acetate and human neutrophil elastase, suggesting that PKCdelta and PKC are involved in Duox1 activation.	Tetradecanoylphorbol Acetate	83-114	protein kinase C delta	Homo sapiens	162-170
15836772-6	2005	We showed here that GFP-E-cadherin, which did not trans-interact due to 2 microm Ca(2+) but associated with alpha- and beta-catenins and p120(ctn), was recruited to the nectin-based cell-cell adhesion sites by the action of TPA.	Tetradecanoylphorbol Acetate	224-227	cadherin 1	Canis lupus familiaris	24-34
15640347-8	2005	Furthermore, the PKCdelta/PKC inhibitor rottlerin prevented the effects induced by phorbol 12-myristate 13-acetate and human neutrophil elastase, suggesting that PKCdelta and PKC are involved in Duox1 activation.	Tetradecanoylphorbol Acetate	83-114	protein kinase C delta	Homo sapiens	17-20
15802798-3	2005	UDCA did not induce HGF production in human dermal fibroblasts, but it potently inhibited phorbol-12-myristate-13-acetate (PMA)- and cholera-toxin-induced HGF production without affecting cell viability.	Tetradecanoylphorbol Acetate	123-126	hepatocyte growth factor	Homo sapiens	155-158
15640347-8	2005	Furthermore, the PKCdelta/PKC inhibitor rottlerin prevented the effects induced by phorbol 12-myristate 13-acetate and human neutrophil elastase, suggesting that PKCdelta and PKC are involved in Duox1 activation.	Tetradecanoylphorbol Acetate	83-114	dual oxidase 1	Homo sapiens	195-200
15836772-7	2005	The nectin inhibitors, which inhibited the trans-interaction of nectin, inhibited the recruitment of GFP-E-cadherin and their associating catenins by the action of TPA.	Tetradecanoylphorbol Acetate	164-167	cadherin 1	Canis lupus familiaris	105-115
15836772-8	2005	Microbeads coated with the extracellular fragment of nectin recruited not only cellular nectin but also GFP-E-cadherin and their associating catenins by the action of TPA.	Tetradecanoylphorbol Acetate	167-170	cadherin 1	Canis lupus familiaris	108-118
15762890-4	2005	In addition, T cell proliferation and cytokine secretion after stimulation with anti-CD3 and anti-CD28 and intracellular cytokine production after stimulation with phorbol myristate acetate (PMA)-ionomycin was determined.	Tetradecanoylphorbol Acetate	191-194	CD28 molecule	Homo sapiens	98-102
15836772-9	2005	These results indicate that when the TJ-like structure is formed by the action of TPA, non-trans-interacting E-cadherin and its associating catenins are recruited to the nectin-based cell-cell adhesion sites and that the trans-interaction of E-cadherin is not essential for the formation of TJs.	Tetradecanoylphorbol Acetate	82-85	cadherin 1	Canis lupus familiaris	109-119
15836772-9	2005	These results indicate that when the TJ-like structure is formed by the action of TPA, non-trans-interacting E-cadherin and its associating catenins are recruited to the nectin-based cell-cell adhesion sites and that the trans-interaction of E-cadherin is not essential for the formation of TJs.	Tetradecanoylphorbol Acetate	82-85	cadherin 1	Canis lupus familiaris	242-252
15735738-4	2005	In our present study, topical application of [6]-gingerol inhibited COX-2 expression in mouse skin stimulated with a prototype tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	142-178	prostaglandin-endoperoxide synthase 2	Mus musculus	68-73
15735738-4	2005	In our present study, topical application of [6]-gingerol inhibited COX-2 expression in mouse skin stimulated with a prototype tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	180-183	prostaglandin-endoperoxide synthase 2	Mus musculus	68-73
15735738-9	2005	Moreover, [6]-gingerol prevented TPA-induced phosphorylation and catalytic activity of p38 mitogen-activated protein (MAP) kinase that regulates COX-2 expression in mouse skin.	Tetradecanoylphorbol Acetate	33-36	mitogen-activated protein kinase 14	Mus musculus	87-90
15735738-9	2005	Moreover, [6]-gingerol prevented TPA-induced phosphorylation and catalytic activity of p38 mitogen-activated protein (MAP) kinase that regulates COX-2 expression in mouse skin.	Tetradecanoylphorbol Acetate	33-36	prostaglandin-endoperoxide synthase 2	Mus musculus	145-150
15735738-10	2005	The p38 MAP kinase inhibitor SB203580 attenuated NF-kappaB activation and subsequent COX-2 induction in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	104-107	mitogen-activated protein kinase 14	Mus musculus	4-7
15735738-10	2005	The p38 MAP kinase inhibitor SB203580 attenuated NF-kappaB activation and subsequent COX-2 induction in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	104-107	prostaglandin-endoperoxide synthase 2	Mus musculus	85-90
15631452-2	2005	Furthermore, effects of glutathione, cytochrome P450 reductase/NADPH, and diaphorase/NADH are relatively small on the fluorescing process of probe 3 with X = Y = F, which is useful to detect O2-* released from neutrophils stimulated by phorbol myristate acetate with satisfactory sensitivity.	Tetradecanoylphorbol Acetate	236-261	dihydrolipoamide dehydrogenase	Homo sapiens	37-84
15470083-4	2005	Phorbol 12-myristate 13-acetate also potentiated cyclic AMP accumulation in cells expressing endogenous AC6, including Chinese hamster ovary cells and differentiated Cath.a differentiated cells.	Tetradecanoylphorbol Acetate	0-31	adenylate cyclase 6	Homo sapiens	104-107
15841177-4	2005	Mice deficient in MMP-9 were resistant to experimental BP, while mice deficient in Plg and both tissue Plg activator (tPA) and urokinase Plg activator (uPA) showed delayed and less intense blister formation induced by antibodies to BP180.	Tetradecanoylphorbol Acetate	118-121	plasminogen	Mus musculus	103-106
15789612-4	2005	PGE2 increased both the PMA-induced cell adhesion and MMP-9 production via EP2/EP4 receptors while it had no effect on the induced TNF-alpha release.	Tetradecanoylphorbol Acetate	24-27	prostaglandin E receptor 2	Homo sapiens	75-78
15735738-11	2005	Taken together, our data suggest that [6]-gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-kappaB signaling pathway.	Tetradecanoylphorbol Acetate	60-63	prostaglandin-endoperoxide synthase 2	Mus musculus	72-77
15735738-11	2005	Taken together, our data suggest that [6]-gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-kappaB signaling pathway.	Tetradecanoylphorbol Acetate	60-63	mitogen-activated protein kinase 14	Mus musculus	127-130
15841177-4	2005	Mice deficient in MMP-9 were resistant to experimental BP, while mice deficient in Plg and both tissue Plg activator (tPA) and urokinase Plg activator (uPA) showed delayed and less intense blister formation induced by antibodies to BP180.	Tetradecanoylphorbol Acetate	118-121	plasminogen	Mus musculus	103-106
15857213-3	2005	With respect to cytotoxicity, we investigated whether purified SNL glycoprotein is able to regulate protein kinase C (PKC) alpha activation and nuclear factor (NF)- kappaB activities in 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced tumor promotion, and whether it has an apoptosis-inducing effect in MCF-7 cells using western blot analysis.	Tetradecanoylphorbol Acetate	186-222	fascin actin-bundling protein 1	Homo sapiens	63-66
15857213-3	2005	With respect to cytotoxicity, we investigated whether purified SNL glycoprotein is able to regulate protein kinase C (PKC) alpha activation and nuclear factor (NF)- kappaB activities in 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced tumor promotion, and whether it has an apoptosis-inducing effect in MCF-7 cells using western blot analysis.	Tetradecanoylphorbol Acetate	224-227	fascin actin-bundling protein 1	Homo sapiens	63-66
15857213-7	2005	In fact, SNL glycoprotein interfered with PKCalpha membrane translocation and inhibited NF-kappaB (p50) protein activity in MCF-7 cells stimulated with TPA (61.68 ng/mL, 100 nM) dose-dependently.	Tetradecanoylphorbol Acetate	152-155	fascin actin-bundling protein 1	Homo sapiens	9-12
16243773-4	2005	A single application of TPA resulted in extensive infiltration of polymorphonuclear neutrophils (PMNs) into the epidermis at 24 h after TPA treatment in PKCepsilon Tg mice while wild-type (WT) mouse skin showed focal infiltration by PMNs.	Tetradecanoylphorbol Acetate	24-27	protein kinase C, epsilon	Mus musculus	153-163
16243773-6	2005	Since the first TPA treatment to DMBA-initiated PKCepsilon Tg mouse skin led to epidermal destruction analogous to skin abrasion, we propose the papilloma-independent phenotype may be explained by death of initiated interfollicular cells originally destined to become papillomas.	Tetradecanoylphorbol Acetate	16-19	protein kinase C, epsilon	Mus musculus	48-58
15761973-1	2005	AIM: To investigate the differential phosphorylation and activation of p38 in hepatocytes by pro-apoptotic Transforming Growth Factor-beta1 (TGF-beta1), pro-survival factors Epidermal Growth Factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) and the potential mechanisms.	Tetradecanoylphorbol Acetate	208-244	mitogen-activated protein kinase 14	Mus musculus	71-74
15823616-7	2005	THP-1 cells expressed exon 9-deleted LH/CG receptor after treatment with PMA.	Tetradecanoylphorbol Acetate	73-76	chorionic gonadotropin subunit beta 5	Homo sapiens	40-42
15823616-11	2005	In the cell cytosol, the ratio of beta-CF and hCG concentrations (beta-CF/hCG) was significantly higher in the PMA-treated cells than in non-PMA-treated cells; however, it did not differ between the PMA-treated cells transfected with exon 9-deleted receptor and those transfected with vector alone.	Tetradecanoylphorbol Acetate	111-114	chorionic gonadotropin subunit beta 5	Homo sapiens	46-49
15823616-11	2005	In the cell cytosol, the ratio of beta-CF and hCG concentrations (beta-CF/hCG) was significantly higher in the PMA-treated cells than in non-PMA-treated cells; however, it did not differ between the PMA-treated cells transfected with exon 9-deleted receptor and those transfected with vector alone.	Tetradecanoylphorbol Acetate	111-114	chorionic gonadotropin subunit beta 5	Homo sapiens	74-77
15823616-11	2005	In the cell cytosol, the ratio of beta-CF and hCG concentrations (beta-CF/hCG) was significantly higher in the PMA-treated cells than in non-PMA-treated cells; however, it did not differ between the PMA-treated cells transfected with exon 9-deleted receptor and those transfected with vector alone.	Tetradecanoylphorbol Acetate	141-144	chorionic gonadotropin subunit beta 5	Homo sapiens	46-49
15761973-1	2005	AIM: To investigate the differential phosphorylation and activation of p38 in hepatocytes by pro-apoptotic Transforming Growth Factor-beta1 (TGF-beta1), pro-survival factors Epidermal Growth Factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) and the potential mechanisms.	Tetradecanoylphorbol Acetate	246-249	mitogen-activated protein kinase 14	Mus musculus	71-74
15623535-4	2005	Small interfering RNA (siRNA) to MARCKS significantly inhibited, whereas overexpression of wild-type MARCKS significantly increased PMA-mediated NT secretion.	Tetradecanoylphorbol Acetate	132-135	myristoylated alanine rich protein kinase C substrate	Homo sapiens	101-107
15761973-6	2005	TPA and EGF also blocked apoptosis induced by TGF-beta1.	Tetradecanoylphorbol Acetate	0-3	transforming growth factor, beta 1	Mus musculus	46-55
15623535-5	2005	Endogenous MARCKS and green fluorescent protein-tagged wild-type MARCKS were translocated from membrane to cytosol upon PMA treatment, further confirming MARCKS activation.	Tetradecanoylphorbol Acetate	120-123	myristoylated alanine rich protein kinase C substrate	Homo sapiens	11-17
15761973-8	2005	The results showed SB202190 had no effect on TGF-beta1-induced phosphorylation of p38, but effectively inhibited both EGF and TPA-induced phosphorylation of p38.	Tetradecanoylphorbol Acetate	126-129	mitogen-activated protein kinase 14	Mus musculus	157-160
15623535-5	2005	Endogenous MARCKS and green fluorescent protein-tagged wild-type MARCKS were translocated from membrane to cytosol upon PMA treatment, further confirming MARCKS activation.	Tetradecanoylphorbol Acetate	120-123	myristoylated alanine rich protein kinase C substrate	Homo sapiens	65-71
15623535-5	2005	Endogenous MARCKS and green fluorescent protein-tagged wild-type MARCKS were translocated from membrane to cytosol upon PMA treatment, further confirming MARCKS activation.	Tetradecanoylphorbol Acetate	120-123	myristoylated alanine rich protein kinase C substrate	Homo sapiens	65-71
15761973-9	2005	CONCLUSION: Pro-apoptotic TGF-beta1, anti-apoptotic TPA and EGF induce the phosphorylation of p38 through different mechanisms that can be distinguished by SB202190.	Tetradecanoylphorbol Acetate	52-55	mitogen-activated protein kinase 14	Mus musculus	94-97
15761973-10	2005	The data suggest that TPA and EGF-induced p38 phosphorylation is through an autophosphorylation-dependent mechanism.	Tetradecanoylphorbol Acetate	22-25	mitogen-activated protein kinase 14	Mus musculus	42-45
15710363-8	2005	Treatment with PMA also abolished the ligand-dependent interaction between PXR and the steroid receptor co-activator 1 protein (SRC1).	Tetradecanoylphorbol Acetate	15-18	nuclear receptor coactivator 1	Homo sapiens	87-118
15710363-8	2005	Treatment with PMA also abolished the ligand-dependent interaction between PXR and the steroid receptor co-activator 1 protein (SRC1).	Tetradecanoylphorbol Acetate	15-18	nuclear receptor coactivator 1	Homo sapiens	128-132
15567061-4	2005	PMA-induced activation of Ras and Raf-1 was inhibited by Ro 31-8220 and manumycin A.	Tetradecanoylphorbol Acetate	0-3	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
15567061-0	2005	Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways.	Tetradecanoylphorbol Acetate	0-31	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	117-122
15567061-8	2005	Taken together, these results indicate that PMA might activate PKC to elicit activation of the Ras/Raf-1/ERK1/2 pathway, which in turn initiates NF-kappaB activation, and finally induces COX-2 expression and PGE2 release in A549 cells.	Tetradecanoylphorbol Acetate	44-47	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	99-104
15567061-2	2005	PMA-induced COX-2 expression was attenuated by PKC inhibitors (Go 6976 and Ro 31-8220), a Ras inhibitor (manumycin A), a Raf-1 inhibitor (GW 5074), a MEK inhibitor (PD 098059), and an NF-kappaB inhibitor (PDTC), but not by a tyrosine kinase inhibitor (genistein) or a p38 MAPK inhibitor (SB 203580).	Tetradecanoylphorbol Acetate	0-3	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	121-126
15703821-10	2005	In a phosphorylation study using the HLF HCC cell line, MARCKS was displaced from the plasma membrane to the cytosol following the activation of protein kinase C (PKC) by phorbol 12-myristrate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	205-208	myristoylated alanine rich protein kinase C substrate	Homo sapiens	56-62
15389569-7	2005	When primary cultured hepatocytes were treated with tetradecanoylphorbol acetate (TPA) to induce T654-phosphorylation of EGFR, we found colocalization of a fraction of EGFR with EEA1, downregulation of EGF-mediated EGFR autophosphorylation, altered ligand-induced intracellular sorting of EGFR, and increased mitogenic signaling through the EGFR-Ras-Raf-ERK pathway.	Tetradecanoylphorbol Acetate	52-80	early endosome antigen 1	Homo sapiens	178-182
15389569-7	2005	When primary cultured hepatocytes were treated with tetradecanoylphorbol acetate (TPA) to induce T654-phosphorylation of EGFR, we found colocalization of a fraction of EGFR with EEA1, downregulation of EGF-mediated EGFR autophosphorylation, altered ligand-induced intracellular sorting of EGFR, and increased mitogenic signaling through the EGFR-Ras-Raf-ERK pathway.	Tetradecanoylphorbol Acetate	82-85	early endosome antigen 1	Homo sapiens	178-182
15537826-9	2005	However, inhibition of PLD-mediated signal generation had only a small effect on TPA-elicited ERK-1/2 phosphorylation (activation), whereas inhibition of ERK-1/2 did not affect PLD activation, suggesting that these two pathways likely operate largely in parallel.	Tetradecanoylphorbol Acetate	81-84	mitogen-activated protein kinase 3	Mus musculus	94-101
15805733-4	2005	In the neuronal stem cell-derived cells, pretreatments with p38 MAP kinase inhibitor, SB203580, and MEK inhibitor, PD98059, could protect GJIC against TPA-induced inhibition of GJIC.	Tetradecanoylphorbol Acetate	151-154	mitogen activated protein kinase 14	Rattus norvegicus	60-63
15611126-8	2005	Investigation of PMA-induced events required for LNCaP and C4-2 apoptosis revealed that p38 activation is dependent on PKCdelta, whereas induction of retinoblastoma protein hypophosphorylation requires both PKC signaling pathways and is downstream of p38 activation in the PKCdelta pathway.	Tetradecanoylphorbol Acetate	17-20	protein kinase C delta	Homo sapiens	273-281
15611126-5	2005	Partial knockdown of PKCdelta inhibited PMA-induced C4-2 cell death almost completely, whereas near-complete knockdown of PKCalpha had no effect.	Tetradecanoylphorbol Acetate	40-43	protein kinase C delta	Homo sapiens	21-29
15611126-6	2005	Knockdown of PKCepsilon alone had no effect, but simultaneous knockdown of both PKCalpha and PKCepsilon in C4-2 cells that continued to express normal levels of PKCdelta inhibited PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	180-183	protein kinase C delta	Homo sapiens	161-169
15579900-6	2005	Expression of TLR3 was positively regulated by the influenza A virus and by dsRNA but not by other inflammatory mediators, including bacterial lipopolysaccharide, the cytokines tumor necrosis factor-alpha and interleukin (IL)-1beta, and the protein kinase C activator phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	268-299	toll like receptor 3	Homo sapiens	14-18
15611126-7	2005	Thus, our data indicate that there is an absolute requirement for PKCdelta in PMA-induced C4-2 apoptosis but that the functions of PKCalpha and PKCepsilon in apoptosis induction are redundant, such that either one (but not both) is required.	Tetradecanoylphorbol Acetate	78-81	protein kinase C delta	Homo sapiens	66-74
15675951-4	2005	This down-regulation depended on multiple regulatory elements in the promoter of MMP-9 including KRE-M9 (which we have recently identified), and a classical 12-o-tetradecanoyl-phorbol-13-acetate-responsive element.	Tetradecanoylphorbol Acetate	157-194	matrix metallopeptidase 9	Mus musculus	81-86
15684480-4	2005	HGF production induced by phorbol 12-myristate 13-acetate (PMA) was potently inhibited by tryptanthrin without any appreciable cytotoxic effect.	Tetradecanoylphorbol Acetate	26-57	hepatocyte growth factor	Homo sapiens	0-3
15684480-4	2005	HGF production induced by phorbol 12-myristate 13-acetate (PMA) was potently inhibited by tryptanthrin without any appreciable cytotoxic effect.	Tetradecanoylphorbol Acetate	59-62	hepatocyte growth factor	Homo sapiens	0-3
15533987-3	2005	On the other hand, phorbol 12-myristate 13-acetate (PMA) inhibits OAG-mediated TRPC3 channel activation, suggesting that phosphorylation of TRPC3 by protein kinase C is a mechanism of receptor-mediated negative feedback.	Tetradecanoylphorbol Acetate	19-50	transient receptor potential cation channel subfamily C member 3	Homo sapiens	79-84
15680335-18	2005	5-Hydroxydecanoate (5-HD), the blocker of mK(ATP) channels, increased both Psi(m) and [Ca2+]m. Phorbol 12-myristate-13-acetate (PMA) mimicked the effects of diazoxide.	Tetradecanoylphorbol Acetate	95-126	ATPase phospholipid transporting 8A2	Homo sapiens	45-48
15533987-3	2005	On the other hand, phorbol 12-myristate 13-acetate (PMA) inhibits OAG-mediated TRPC3 channel activation, suggesting that phosphorylation of TRPC3 by protein kinase C is a mechanism of receptor-mediated negative feedback.	Tetradecanoylphorbol Acetate	19-50	transient receptor potential cation channel subfamily C member 3	Homo sapiens	140-145
15680335-18	2005	5-Hydroxydecanoate (5-HD), the blocker of mK(ATP) channels, increased both Psi(m) and [Ca2+]m. Phorbol 12-myristate-13-acetate (PMA) mimicked the effects of diazoxide.	Tetradecanoylphorbol Acetate	128-131	ATPase phospholipid transporting 8A2	Homo sapiens	45-48
15533987-3	2005	On the other hand, phorbol 12-myristate 13-acetate (PMA) inhibits OAG-mediated TRPC3 channel activation, suggesting that phosphorylation of TRPC3 by protein kinase C is a mechanism of receptor-mediated negative feedback.	Tetradecanoylphorbol Acetate	52-55	transient receptor potential cation channel subfamily C member 3	Homo sapiens	79-84
15533987-3	2005	On the other hand, phorbol 12-myristate 13-acetate (PMA) inhibits OAG-mediated TRPC3 channel activation, suggesting that phosphorylation of TRPC3 by protein kinase C is a mechanism of receptor-mediated negative feedback.	Tetradecanoylphorbol Acetate	52-55	transient receptor potential cation channel subfamily C member 3	Homo sapiens	140-145
15390308-9	2005	Functionally, exposure to 33 nM 12-O-tetradecanoyl phorbol mirystate-13-acetate (TPA) induced DOR-1 cell differentiation with appearance of cytoplasmic extensions.	Tetradecanoylphorbol Acetate	81-84	opioid receptor delta 1	Homo sapiens	94-99
15498788-8	2005	Topical application of IH-901 onto shaven backs of female ICR mice led to the inhibition of TPA-induced expression of COX-2 and production of prostaglandin E(2).	Tetradecanoylphorbol Acetate	92-95	prostaglandin-endoperoxide synthase 2	Mus musculus	118-123
15498788-15	2005	Taken together, these findings suggest that IH-901 exerts anti-inflammatory effects by inhibiting TPA-induced COX-2 expression, which may contribute to its antitumor-promoting effects on mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	98-101	prostaglandin-endoperoxide synthase 2	Mus musculus	110-115
15639337-9	2005	While TPA-induced activation of nuclear factor-(kappa)B remained unaffected by both extracts, they inhibited TPA-induced activation of activator protein-1 (AP-1) and attenuated the expression of its key component c-Fos.	Tetradecanoylphorbol Acetate	6-9	jun proto-oncogene	Mus musculus	135-154
15713899-6	2005	In 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated COLO 205 cells, an increase in MMP-2 protein expression and enzyme activity, as well as of protein kinase C (PKC) alpha protein translocation, extracellular signal-regulated kinase (ERK) 1/2 protein phosphorylation, and c-Jun protein expression was observed.	Tetradecanoylphorbol Acetate	3-39	matrix metallopeptidase 2	Homo sapiens	88-93
15713899-6	2005	In 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated COLO 205 cells, an increase in MMP-2 protein expression and enzyme activity, as well as of protein kinase C (PKC) alpha protein translocation, extracellular signal-regulated kinase (ERK) 1/2 protein phosphorylation, and c-Jun protein expression was observed.	Tetradecanoylphorbol Acetate	41-44	matrix metallopeptidase 2	Homo sapiens	88-93
15639337-9	2005	While TPA-induced activation of nuclear factor-(kappa)B remained unaffected by both extracts, they inhibited TPA-induced activation of activator protein-1 (AP-1) and attenuated the expression of its key component c-Fos.	Tetradecanoylphorbol Acetate	6-9	jun proto-oncogene	Mus musculus	156-160
15713899-8	2005	Addition of myricetin but not myricitrin suppressed TPA-induced MMP-2 protein expression in COLO 205 cells by blocking the TPA-induced events, including translocation of PKCalpha from cytosol to membrane, phosphorylation of ERK1/2 protein, and induction of c-Jun protein expression.	Tetradecanoylphorbol Acetate	52-55	matrix metallopeptidase 2	Homo sapiens	64-69
15639337-9	2005	While TPA-induced activation of nuclear factor-(kappa)B remained unaffected by both extracts, they inhibited TPA-induced activation of activator protein-1 (AP-1) and attenuated the expression of its key component c-Fos.	Tetradecanoylphorbol Acetate	109-112	jun proto-oncogene	Mus musculus	135-154
15713899-9	2005	Addition of PD98059 or GF-109203X significantly enhanced the inhibitory effect of myricetin on MMP-2 enzyme activity induced by TPA.	Tetradecanoylphorbol Acetate	128-131	matrix metallopeptidase 2	Homo sapiens	95-100
15713899-11	2005	Results of the present study indicate that myricetin significantly blocked both endogenous and TPA-induced MMP-2 enzyme activity by inhibiting its protein expression and enzyme activity.	Tetradecanoylphorbol Acetate	95-98	matrix metallopeptidase 2	Homo sapiens	107-112
15639337-6	2005	In the present study, we investigated the effects of methanolic extracts of CB and DC on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 expression in mouse skin.	Tetradecanoylphorbol Acetate	89-125	cytochrome c oxidase II, mitochondrial	Mus musculus	140-145
15639337-6	2005	In the present study, we investigated the effects of methanolic extracts of CB and DC on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 expression in mouse skin.	Tetradecanoylphorbol Acetate	127-130	cytochrome c oxidase II, mitochondrial	Mus musculus	140-145
15639337-9	2005	While TPA-induced activation of nuclear factor-(kappa)B remained unaffected by both extracts, they inhibited TPA-induced activation of activator protein-1 (AP-1) and attenuated the expression of its key component c-Fos.	Tetradecanoylphorbol Acetate	109-112	jun proto-oncogene	Mus musculus	156-160
15639337-7	2005	Topical application of both extracts inhibited TPA-induced COX-2 expression.	Tetradecanoylphorbol Acetate	47-50	cytochrome c oxidase II, mitochondrial	Mus musculus	59-64
15639337-8	2005	As an underlying mechanism of COX-2 inhibition, these extracts diminished TPA-stimulated catalytic activity of extracellular signal-regulated protein kinase (ERK), which is known to regulate the activation of eukaryotic transcription factors mediating COX-2 induction.	Tetradecanoylphorbol Acetate	74-77	cytochrome c oxidase II, mitochondrial	Mus musculus	30-35
15513920-8	2005	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate blunted VR1 desensitization, and this effect was reversible in the presence of the PKC inhibitor bisindolylmaleimide I.	Tetradecanoylphorbol Acetate	37-68	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	77-80
15639337-8	2005	As an underlying mechanism of COX-2 inhibition, these extracts diminished TPA-stimulated catalytic activity of extracellular signal-regulated protein kinase (ERK), which is known to regulate the activation of eukaryotic transcription factors mediating COX-2 induction.	Tetradecanoylphorbol Acetate	74-77	cytochrome c oxidase II, mitochondrial	Mus musculus	252-257
15561096-7	2005	We show that coincubation of TPA with the protein synthesis inhibitor cycloheximide or the transcription inhibitor actinomycin D results in synergistic enhancement of the level of activated ERK1/2.	Tetradecanoylphorbol Acetate	29-32	mitogen activated protein kinase 3	Rattus norvegicus	190-196
16273125-2	2005	Activation of platelets by thrombin or phorbol 12-myristate 13-acetate (PMA), a PKC activator, initiated a rapid rise in the activity of Na(+)/H(+) exchanger and secretion of 5-HT.	Tetradecanoylphorbol Acetate	39-70	solute carrier family 9 member C1	Homo sapiens	137-157
15659291-3	2005	Pretreatment with resiniferatoxin [200 microg/kg, subcutaneous (s.c.)] blocked the PMA-induced nociceptive behaviour, suggesting that vanilloid VR1 receptor-expressing primary sensory neurons play a major role in this response.	Tetradecanoylphorbol Acetate	83-86	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	144-147
16273125-2	2005	Activation of platelets by thrombin or phorbol 12-myristate 13-acetate (PMA), a PKC activator, initiated a rapid rise in the activity of Na(+)/H(+) exchanger and secretion of 5-HT.	Tetradecanoylphorbol Acetate	72-75	solute carrier family 9 member C1	Homo sapiens	137-157
15574370-8	2005	The carboxyl-terminal lysines of S100A10 bind tPA and plasminogen resulting in the stimulation of tPA-dependent plasmin production.	Tetradecanoylphorbol Acetate	98-101	plasminogen	Homo sapiens	54-61
16273125-3	2005	Both thrombin- and PMA-evoked activation of Na(+)/H(+) exchanger was less pronounced in the presence of ethyl-isopropyl-amiloride (EIPA), an NHE inhibitor, and by GF 109203X, a PKC inhibitor.	Tetradecanoylphorbol Acetate	19-22	solute carrier family 9 member C1	Homo sapiens	44-64
16273125-3	2005	Both thrombin- and PMA-evoked activation of Na(+)/H(+) exchanger was less pronounced in the presence of ethyl-isopropyl-amiloride (EIPA), an NHE inhibitor, and by GF 109203X, a PKC inhibitor.	Tetradecanoylphorbol Acetate	19-22	solute carrier family 9 member C1	Homo sapiens	141-144
15632005-2	2005	We reported that FVB/N transgenic mouse lines that overexpress (8- or 18-fold) PKC-epsilon protein in basal epidermal cells and cells of the hair follicle develop papilloma-independent squamous cell carcinoma (SCC) elicited by 7,12-dimethylbenz(a)anthracene initiation and 12-O-tetradecanoylphorbol-13-acetate-promotion or by repeated ultraviolet radiation exposures.	Tetradecanoylphorbol Acetate	273-309	protein kinase C, epsilon	Mus musculus	79-90
15589400-4	2005	As a result, it was found that wogonin (10-100 microM) clearly down-regulated COX-2 expression from NIH/3T3 cells treated with 12-O-tetradecanoylphorbol 13-acetate, interleukin-1beta or tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	127-163	prostaglandin-endoperoxide synthase 2	Mus musculus	78-83
18095109-6	2005	Moreover, antisense oligonucleotides and curcumin inhibited phorbol-12-myristate-13-acetate (PMA)-induced RelA/NF-kappaB expression or activation (or both), down-regulated u-PA expression, and reduced the migration and invasive potentials of T98G glioma cells.	Tetradecanoylphorbol Acetate	60-91	RELA proto-oncogene, NF-kB subunit	Homo sapiens	106-110
16243773-1	2005	Protein kinase C epsilon (PKCepsilon) overexpressing transgenic (PKCepsilon Tg) mice develop papilloma-independent squamous cell carcinomas (SCC) elicited by 7,12-dimethylbenz[a]anthracene (DMBA) tumor initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA) tumor promotion.	Tetradecanoylphorbol Acetate	217-253	protein kinase C, epsilon	Mus musculus	26-36
16243773-1	2005	Protein kinase C epsilon (PKCepsilon) overexpressing transgenic (PKCepsilon Tg) mice develop papilloma-independent squamous cell carcinomas (SCC) elicited by 7,12-dimethylbenz[a]anthracene (DMBA) tumor initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA) tumor promotion.	Tetradecanoylphorbol Acetate	217-253	protein kinase C, epsilon	Mus musculus	65-75
16243773-1	2005	Protein kinase C epsilon (PKCepsilon) overexpressing transgenic (PKCepsilon Tg) mice develop papilloma-independent squamous cell carcinomas (SCC) elicited by 7,12-dimethylbenz[a]anthracene (DMBA) tumor initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA) tumor promotion.	Tetradecanoylphorbol Acetate	255-258	protein kinase C, epsilon	Mus musculus	26-36
18095109-6	2005	Moreover, antisense oligonucleotides and curcumin inhibited phorbol-12-myristate-13-acetate (PMA)-induced RelA/NF-kappaB expression or activation (or both), down-regulated u-PA expression, and reduced the migration and invasive potentials of T98G glioma cells.	Tetradecanoylphorbol Acetate	93-96	RELA proto-oncogene, NF-kB subunit	Homo sapiens	106-110
16243773-1	2005	Protein kinase C epsilon (PKCepsilon) overexpressing transgenic (PKCepsilon Tg) mice develop papilloma-independent squamous cell carcinomas (SCC) elicited by 7,12-dimethylbenz[a]anthracene (DMBA) tumor initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA) tumor promotion.	Tetradecanoylphorbol Acetate	255-258	protein kinase C, epsilon	Mus musculus	65-75
16116958-6	2005	58+/-1 626.57) and the expression of IL-5 mRNA (0.8300+/-0.0294) in T lymphocytes stimulated with PMA were significantly higher than these in blank control (20888.47 +/- 1103.56 and 0.3050 +/- 0.0208, respectively, P&lt; 0.01), while the indexes (23219.83 +/- 1024.86 and 0.3425 +/- 0.0171 respectively) of T lymphocytes stimulated with PMA and AP-1 decoy ODNs were significantly inhibited, as compared with group B (P&lt; 0.01).	Tetradecanoylphorbol Acetate	98-101	interleukin 5	Homo sapiens	37-41
15541342-4	2004	IL-1alpha, IL-1beta, and TNF-alpha alone had minimal stimulating effects on HGF production in human dermal fibroblasts, but they strongly inhibited production of HGF induced by cholera toxin, 8-bromo-cAMP, EGF, and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	215-246	hepatocyte growth factor	Homo sapiens	162-165
15541342-5	2004	Moreover, although the high level of HGF production in MRC-5 cells was enhanced by PMA and less markedly by IL-1beta, HGF production in MRC-5 cells treated with PMA plus IL-1beta was less than that in the cells treated with PMA alone.	Tetradecanoylphorbol Acetate	83-86	hepatocyte growth factor	Homo sapiens	37-40
15541342-5	2004	Moreover, although the high level of HGF production in MRC-5 cells was enhanced by PMA and less markedly by IL-1beta, HGF production in MRC-5 cells treated with PMA plus IL-1beta was less than that in the cells treated with PMA alone.	Tetradecanoylphorbol Acetate	161-164	hepatocyte growth factor	Homo sapiens	118-121
16116958-6	2005	58+/-1 626.57) and the expression of IL-5 mRNA (0.8300+/-0.0294) in T lymphocytes stimulated with PMA were significantly higher than these in blank control (20888.47 +/- 1103.56 and 0.3050 +/- 0.0208, respectively, P&lt; 0.01), while the indexes (23219.83 +/- 1024.86 and 0.3425 +/- 0.0171 respectively) of T lymphocytes stimulated with PMA and AP-1 decoy ODNs were significantly inhibited, as compared with group B (P&lt; 0.01).	Tetradecanoylphorbol Acetate	98-101	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	345-349
15458367-4	2005	PKCepsilon transgenic mice were observed to be highly sensitive to the development of papilloma-independent metastatic squamous cell carcinoma (mSCC) elicited either by repeated exposure to UVR or by the 7,12-Dimethylbenzanthracene-TPA tumor promotion protocol.	Tetradecanoylphorbol Acetate	232-235	protein kinase C, epsilon	Mus musculus	0-10
15330761-9	2004	Western blot analysis indicated the presence of several PKC isoforms in the VA-13 cell line; however, PMA pre-treatment specifically down-regulated alpha and betaI, suggesting a role for one or more of these proteins in SOD2 induction.	Tetradecanoylphorbol Acetate	102-105	superoxide dismutase 2	Homo sapiens	220-224
15672459-10	2005	Using this approach, we identified two proteins, syndecan-4 and hepatoma-derived growth factor, whose abundances increased in media of cells treated with PMA.	Tetradecanoylphorbol Acetate	154-157	syndecan 4	Homo sapiens	49-94
15456774-9	2004	Furthermore, 7E4 abrogated LFA-1/ICAM-1 adhesion of phorbol 12-myristate 13-acetate-treated MOLT-4 cells.	Tetradecanoylphorbol Acetate	52-83	integrin subunit alpha L	Homo sapiens	27-32
15330761-2	2004	Using the VA-13 cell line, we studied the regulation of SOD2 upon treatment with PMA.	Tetradecanoylphorbol Acetate	81-84	superoxide dismutase 2	Homo sapiens	56-60
15659805-2	2004	Several reports suggest that activation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) plays a key role in the disrupted GJIC by hydrogen peroxide, 12-O-tetradecanoylphorbol-13-acetate, and quinones in rat liver epithelial cells.	Tetradecanoylphorbol Acetate	168-204	mitogen activated protein kinase 3	Rattus norvegicus	99-105
15490242-11	2004	Non-adherent cells could be activated with phorbol 12-myristate 13-acetate after flow over any mucin or combination of mucins.	Tetradecanoylphorbol Acetate	43-74	LOC100508689	Homo sapiens	95-100
15308560-5	2004	Cell differentiation with ATRA and PMA, but not with vitamin D3 or DMSO, results in phosphorylation of protein kinase Cdelta (PKCdelta), and the PKCdelta-specific inhibitor rottlerin nearly eliminates the ATRA- and PMA-induced expression of PLSCR1, while ectopic expression of a constitutively active form of PKCdelta directly increases PLSCR1 expression.	Tetradecanoylphorbol Acetate	35-38	protein kinase C delta	Homo sapiens	103-124
15465640-2	2004	We isolated a glycoprotein (150 kDa) from SNL and tested its effect on the modulation of transcriptional factors (NF-kappa B and AP-1) and iNO production in TPA induced-MCF-7 cells, which are part of the human breast cancer cell line, without estrogen receptors.	Tetradecanoylphorbol Acetate	157-160	fascin actin-bundling protein 1	Homo sapiens	42-45
15504748-6	2004	The cAMP production by PMA, but not histamine, was significantly reversed by Ro 31-8220 (1 microM) and the selective inhibitor of the novel PKCdelta, rottlerin (1-3 microM), but not the selective inhibitor of the classical PKC isoforms, Go 6976 (0.01-0.1 microM).	Tetradecanoylphorbol Acetate	23-26	protein kinase C delta	Homo sapiens	140-148
15666830-7	2004	Taken together these results suggest that TPA inhibits the AII-dependent activation of CYP11B2 via the p44/42 MAPK signaling pathway leading to an increase of the level of nuclear JunB.	Tetradecanoylphorbol Acetate	42-45	interferon induced protein 44	Homo sapiens	103-106
15604236-5	2004	PLCepsilon(-/-) mice exhibit delayed onset and markedly reduced incidence of skin squamous tumors induced by initiation with 7,12-dimethylbenz(a)anthracene followed by promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	183-219	phospholipase C, epsilon 1	Mus musculus	0-10
15604236-5	2004	PLCepsilon(-/-) mice exhibit delayed onset and markedly reduced incidence of skin squamous tumors induced by initiation with 7,12-dimethylbenz(a)anthracene followed by promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	221-224	phospholipase C, epsilon 1	Mus musculus	0-10
15308560-0	2004	Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation.	Tetradecanoylphorbol Acetate	49-74	protein kinase C delta	Homo sapiens	0-21
15539760-4	2004	In transient and stable clones of C12 cells expressing cPLA2alpha, Ca2+ ionophore A23187 and phorbol myristate acetate (PMA) stimulated AA release within 90 min, although no response to TNFalpha was observed within 6 h. These results suggest that C12 cells may lack the components necessary for TNFalpha-induced AA release, in addition to cPLA2alpha.	Tetradecanoylphorbol Acetate	93-118	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	55-65
15308560-5	2004	Cell differentiation with ATRA and PMA, but not with vitamin D3 or DMSO, results in phosphorylation of protein kinase Cdelta (PKCdelta), and the PKCdelta-specific inhibitor rottlerin nearly eliminates the ATRA- and PMA-induced expression of PLSCR1, while ectopic expression of a constitutively active form of PKCdelta directly increases PLSCR1 expression.	Tetradecanoylphorbol Acetate	35-38	protein kinase C delta	Homo sapiens	126-134
15539760-4	2004	In transient and stable clones of C12 cells expressing cPLA2alpha, Ca2+ ionophore A23187 and phorbol myristate acetate (PMA) stimulated AA release within 90 min, although no response to TNFalpha was observed within 6 h. These results suggest that C12 cells may lack the components necessary for TNFalpha-induced AA release, in addition to cPLA2alpha.	Tetradecanoylphorbol Acetate	93-118	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	339-349
15539760-4	2004	In transient and stable clones of C12 cells expressing cPLA2alpha, Ca2+ ionophore A23187 and phorbol myristate acetate (PMA) stimulated AA release within 90 min, although no response to TNFalpha was observed within 6 h. These results suggest that C12 cells may lack the components necessary for TNFalpha-induced AA release, in addition to cPLA2alpha.	Tetradecanoylphorbol Acetate	120-123	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	55-65
15541021-4	2004	Addition of 12-O-tetradecanoyl-phorbol-13-acetate (10 ng/ml) to the culture medium caused an increase of production of MMP-2 and MMP-9 by cultured uveal melanocytes, and also stimulated the transcription of MMP-2 and MMP-9 of these cells.	Tetradecanoylphorbol Acetate	12-49	matrix metallopeptidase 2	Homo sapiens	207-212
15308560-5	2004	Cell differentiation with ATRA and PMA, but not with vitamin D3 or DMSO, results in phosphorylation of protein kinase Cdelta (PKCdelta), and the PKCdelta-specific inhibitor rottlerin nearly eliminates the ATRA- and PMA-induced expression of PLSCR1, while ectopic expression of a constitutively active form of PKCdelta directly increases PLSCR1 expression.	Tetradecanoylphorbol Acetate	35-38	protein kinase C delta	Homo sapiens	145-153
15465640-5	2004	Results in this experiment showed that SNL glycoprotein inhibits 12-O-Tetra decanoylphorbol-13-acetate (TPA; 100 nM)-induced DNA-binding activities of NF-kappaB and AP-1, and enhances NO production in MCF-7 cells.	Tetradecanoylphorbol Acetate	104-107	fascin actin-bundling protein 1	Homo sapiens	39-42
15465640-6	2004	That is, our results indicated that SNL glycoprotein has the capacity to modulate the TPA-induced DNA-binding activities of transcription factors and NO production, which play a critical role with respect to cytotoxicity in MCF-7 cells.	Tetradecanoylphorbol Acetate	86-89	fascin actin-bundling protein 1	Homo sapiens	36-39
15465640-7	2004	Therefore, SNL glycoprotein might be one of the agents that blocks TPA-mediated signal responses in tumor cells.	Tetradecanoylphorbol Acetate	67-70	fascin actin-bundling protein 1	Homo sapiens	11-14
15539760-4	2004	In transient and stable clones of C12 cells expressing cPLA2alpha, Ca2+ ionophore A23187 and phorbol myristate acetate (PMA) stimulated AA release within 90 min, although no response to TNFalpha was observed within 6 h. These results suggest that C12 cells may lack the components necessary for TNFalpha-induced AA release, in addition to cPLA2alpha.	Tetradecanoylphorbol Acetate	120-123	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	339-349
15539760-6	2004	However, PMA-induced AA release from C12 cells expressing mutant cPLA2alpha S505A (mutation of Ser505 to Ala), which is not phosphorylated by ERK1/2, was similar to that from L929 cells and C12 cells expressing wild-type cPLA2alpha.	Tetradecanoylphorbol Acetate	9-12	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	65-70
15539760-6	2004	However, PMA-induced AA release from C12 cells expressing mutant cPLA2alpha S505A (mutation of Ser505 to Ala), which is not phosphorylated by ERK1/2, was similar to that from L929 cells and C12 cells expressing wild-type cPLA2alpha.	Tetradecanoylphorbol Acetate	9-12	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	65-75
15308560-5	2004	Cell differentiation with ATRA and PMA, but not with vitamin D3 or DMSO, results in phosphorylation of protein kinase Cdelta (PKCdelta), and the PKCdelta-specific inhibitor rottlerin nearly eliminates the ATRA- and PMA-induced expression of PLSCR1, while ectopic expression of a constitutively active form of PKCdelta directly increases PLSCR1 expression.	Tetradecanoylphorbol Acetate	35-38	protein kinase C delta	Homo sapiens	145-153
15308560-5	2004	Cell differentiation with ATRA and PMA, but not with vitamin D3 or DMSO, results in phosphorylation of protein kinase Cdelta (PKCdelta), and the PKCdelta-specific inhibitor rottlerin nearly eliminates the ATRA- and PMA-induced expression of PLSCR1, while ectopic expression of a constitutively active form of PKCdelta directly increases PLSCR1 expression.	Tetradecanoylphorbol Acetate	215-218	protein kinase C delta	Homo sapiens	103-124
15308560-5	2004	Cell differentiation with ATRA and PMA, but not with vitamin D3 or DMSO, results in phosphorylation of protein kinase Cdelta (PKCdelta), and the PKCdelta-specific inhibitor rottlerin nearly eliminates the ATRA- and PMA-induced expression of PLSCR1, while ectopic expression of a constitutively active form of PKCdelta directly increases PLSCR1 expression.	Tetradecanoylphorbol Acetate	215-218	protein kinase C delta	Homo sapiens	126-134
15520189-4	2004	Further analysis revealed that Smad3 knockout mice were resistant to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced epidermal hyperproliferation.	Tetradecanoylphorbol Acetate	69-105	SMAD family member 3	Mus musculus	31-36
15520189-4	2004	Further analysis revealed that Smad3 knockout mice were resistant to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced epidermal hyperproliferation.	Tetradecanoylphorbol Acetate	107-110	SMAD family member 3	Mus musculus	31-36
15308560-5	2004	Cell differentiation with ATRA and PMA, but not with vitamin D3 or DMSO, results in phosphorylation of protein kinase Cdelta (PKCdelta), and the PKCdelta-specific inhibitor rottlerin nearly eliminates the ATRA- and PMA-induced expression of PLSCR1, while ectopic expression of a constitutively active form of PKCdelta directly increases PLSCR1 expression.	Tetradecanoylphorbol Acetate	215-218	protein kinase C delta	Homo sapiens	145-153
15520189-5	2004	Concurrently, increased apoptosis was observed in TPA-treated Smad3(-/-) skin and papillomas when compared with those of wild-type mice.	Tetradecanoylphorbol Acetate	50-53	SMAD family member 3	Mus musculus	62-67
15308560-5	2004	Cell differentiation with ATRA and PMA, but not with vitamin D3 or DMSO, results in phosphorylation of protein kinase Cdelta (PKCdelta), and the PKCdelta-specific inhibitor rottlerin nearly eliminates the ATRA- and PMA-induced expression of PLSCR1, while ectopic expression of a constitutively active form of PKCdelta directly increases PLSCR1 expression.	Tetradecanoylphorbol Acetate	215-218	protein kinase C delta	Homo sapiens	145-153
15520189-6	2004	Expression levels of activator protein-1 family members (c-jun, junB, junD, and c-fos) and transforming growth factor (TGF)-alpha were significantly lower in TPA-treated Smad3(-/-) skin, cultured keratinocytes, and papillomas, as compared with Smad3(+/+) controls.	Tetradecanoylphorbol Acetate	158-161	jun proto-oncogene	Mus musculus	57-62
15231488-9	2004	Phorbol myristate acetate also stimulated mucin secretion in a calphostin C-sensitive manner.	Tetradecanoylphorbol Acetate	0-25	LOC100508689	Homo sapiens	42-47
15520189-6	2004	Expression levels of activator protein-1 family members (c-jun, junB, junD, and c-fos) and transforming growth factor (TGF)-alpha were significantly lower in TPA-treated Smad3(-/-) skin, cultured keratinocytes, and papillomas, as compared with Smad3(+/+) controls.	Tetradecanoylphorbol Acetate	158-161	SMAD family member 3	Mus musculus	170-175
15349752-4	2004	For experimentally induced tumor promotion, we investigated whether the SNL glycoprotein was able to regulate the activity of protein kinase C alpha (PKCalpha), the DNA binding activation of nuclear factor-kappa B (NF-kappaB), the activity of NF-kappaB protein, and the production of nitric oxide (NO) in HCT-116 cells stimulated with 12-O-tetradecanoylphorbol 13-acetate (TPA) using electrophoretic mobility shift assays (EMSA), Western blot analysis, and NO assays.	Tetradecanoylphorbol Acetate	335-371	fascin actin-bundling protein 1	Homo sapiens	72-75
15520189-6	2004	Expression levels of activator protein-1 family members (c-jun, junB, junD, and c-fos) and transforming growth factor (TGF)-alpha were significantly lower in TPA-treated Smad3(-/-) skin, cultured keratinocytes, and papillomas, as compared with Smad3(+/+) controls.	Tetradecanoylphorbol Acetate	158-161	SMAD family member 3	Mus musculus	244-249
15520189-9	2004	Given that TGF-beta1 is a well-documented TPA-responsive gene and also has a potent chemotactic effect on macrophages, our study suggests that Smad3 may be required for TPA-mediated tumor promotion through inducing TGF-beta1-responsive genes, which are required for tumor promotion, and through mediating TGF-beta1-induced macrophage infiltration.	Tetradecanoylphorbol Acetate	42-45	transforming growth factor, beta 1	Mus musculus	11-20
15520189-9	2004	Given that TGF-beta1 is a well-documented TPA-responsive gene and also has a potent chemotactic effect on macrophages, our study suggests that Smad3 may be required for TPA-mediated tumor promotion through inducing TGF-beta1-responsive genes, which are required for tumor promotion, and through mediating TGF-beta1-induced macrophage infiltration.	Tetradecanoylphorbol Acetate	42-45	SMAD family member 3	Mus musculus	143-148
15520189-9	2004	Given that TGF-beta1 is a well-documented TPA-responsive gene and also has a potent chemotactic effect on macrophages, our study suggests that Smad3 may be required for TPA-mediated tumor promotion through inducing TGF-beta1-responsive genes, which are required for tumor promotion, and through mediating TGF-beta1-induced macrophage infiltration.	Tetradecanoylphorbol Acetate	169-172	transforming growth factor, beta 1	Mus musculus	11-20
15520189-9	2004	Given that TGF-beta1 is a well-documented TPA-responsive gene and also has a potent chemotactic effect on macrophages, our study suggests that Smad3 may be required for TPA-mediated tumor promotion through inducing TGF-beta1-responsive genes, which are required for tumor promotion, and through mediating TGF-beta1-induced macrophage infiltration.	Tetradecanoylphorbol Acetate	169-172	SMAD family member 3	Mus musculus	143-148
15666819-3	2004	To this end we isolated marmoset and rhesus adrenocortical cells, and treated the cells with known regulators of P450c17 expression for 48 h. P450c17 protein increased with Forskolin (F) treatment, but was marginally inhibited by AII (A) and TPA (T) alone.	Tetradecanoylphorbol Acetate	242-245	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	142-149
15666830-2	2004	Here we report that TPA increased the level of phospho-p44/42 MAPK but AII did not.	Tetradecanoylphorbol Acetate	20-23	interferon induced protein 44	Homo sapiens	55-58
15280379-9	2004	Knockdown of Eve-1 by small interfering RNA in HT1080 cells reduced the shedding of proHB-EGF induced by angiotensin II and 12-O-tetradecanoylphorbol-13-acetate, as well as the shedding of pro-transforming growth factor-alpha, promphiregulin, and proepiregulin by 12-O-tetradecanoylphorbol-13-acetate, suggesting that Eve-1 plays a role in positively regulating the activity of ADAMs in the signaling of EGFR-ligand shedding.	Tetradecanoylphorbol Acetate	124-160	SH3 domain containing 19	Homo sapiens	13-18
15280379-9	2004	Knockdown of Eve-1 by small interfering RNA in HT1080 cells reduced the shedding of proHB-EGF induced by angiotensin II and 12-O-tetradecanoylphorbol-13-acetate, as well as the shedding of pro-transforming growth factor-alpha, promphiregulin, and proepiregulin by 12-O-tetradecanoylphorbol-13-acetate, suggesting that Eve-1 plays a role in positively regulating the activity of ADAMs in the signaling of EGFR-ligand shedding.	Tetradecanoylphorbol Acetate	264-300	SH3 domain containing 19	Homo sapiens	13-18
15379562-2	2004	Lp(a) may interfere with tPA-mediated plasminogen activation in fibrinolysis, thereby generating a hypercoaguable state in vivo.	Tetradecanoylphorbol Acetate	25-28	lipoprotein(a)	Homo sapiens	0-5
15379562-9	2004	Differential binding kinetics between Glu(1)-/Lys(78)-plasminogen and apo(a) may explain why Lp(a) is a stronger inhibitor of tPA-mediated Glu(1)-plasminogen activation compared to Lys(78)-plasminogen activation.	Tetradecanoylphorbol Acetate	126-129	lipoprotein(a)	Homo sapiens	93-98
15374947-6	2004	Furthermore, TGF-beta-mediated suppression of immune cell function was exaggerated in Ahsg-/- animals, as shown by inhibition of macrophage activation and reduction in 12-O-tetradecanoylphorbol 13-acetate-induced cutaneous inflammation.	Tetradecanoylphorbol Acetate	168-204	transforming growth factor, beta 1	Mus musculus	13-21
15286717-7	2004	U251MG cells expressed IL-8 receptors CXCR-1 and -2, and Matrigel invasion assay revealed that CsA attenuated A23187/PMA-dependent stimulation of invasive potential, probably by inhibiting IL-8 production.	Tetradecanoylphorbol Acetate	117-120	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	95-98
15342368-5	2004	The benzo(a)pyrene + TPA also showed increase in tumor incidence in NQO2-/- mice but to a less extent than DMBA.	Tetradecanoylphorbol Acetate	21-24	N-ribosyldihydronicotinamide quinone reductase 2	Mus musculus	68-72
15322235-7	2004	Down-regulation of PKC by prolonged treatment with 1 microM 12-O-tetradecanoylphorbol-13 acetate for 24 h inhibited the potentiating action of bFGF.	Tetradecanoylphorbol Acetate	60-96	fibroblast growth factor 2	Rattus norvegicus	143-147
15194008-7	2004	Moreover, emodin inhibited TPA-induced degradation of inhibitor of kappaBalpha, nuclear translocation of p65, and NF-kappaB DNA-binding activity.	Tetradecanoylphorbol Acetate	27-30	RELA proto-oncogene, NF-kB subunit	Homo sapiens	105-108
15184054-7	2004	Unstimulated peripheral blood mononuclear cells were shown to secrete Grx1, but upon 12-O-tetradecanoylphorbol-13-acetate activation, the secretion of Grx1 was strongly suppressed.	Tetradecanoylphorbol Acetate	85-121	glutaredoxin	Homo sapiens	151-155
15232218-2	2004	In the present study we showed that expression of RANK was strongly induced by phorbol-12-myristate-13-acetate (PMA) during monocyte differentiation of U937 cells, and was enhanced by concomitant treatment with vitamin D3.	Tetradecanoylphorbol Acetate	79-110	TNF receptor superfamily member 11a	Homo sapiens	50-54
15232218-2	2004	In the present study we showed that expression of RANK was strongly induced by phorbol-12-myristate-13-acetate (PMA) during monocyte differentiation of U937 cells, and was enhanced by concomitant treatment with vitamin D3.	Tetradecanoylphorbol Acetate	112-115	TNF receptor superfamily member 11a	Homo sapiens	50-54
15481789-4	2004	Administration of 12-o-tetradecanoyl- phorbol-13-acetate (TPA) increased the release of MMP-9 but not of MMP-2.	Tetradecanoylphorbol Acetate	58-61	matrix metallopeptidase 2	Homo sapiens	105-110
15067002-5	2004	When PLD1 or PLD2 was introduced into those cells by an adenoviral gene-transfer technique, both PLD1 and PLD2 were activated by TPA.	Tetradecanoylphorbol Acetate	129-132	phospholipase D1	Mus musculus	5-9
15067002-5	2004	When PLD1 or PLD2 was introduced into those cells by an adenoviral gene-transfer technique, both PLD1 and PLD2 were activated by TPA.	Tetradecanoylphorbol Acetate	129-132	phospholipase D1	Mus musculus	97-101
15067002-8	2004	The effects of TPA on the down-regulation of basal or alpha-melanocyte-stimulating hormone-enhanced melanogenesis were almost completely blocked by expressing a lipase activity-negative mutant, LN-PLD2, but not by LN-PLD1.	Tetradecanoylphorbol Acetate	15-18	pro-opiomelanocortin-alpha	Mus musculus	54-90
15067002-8	2004	The effects of TPA on the down-regulation of basal or alpha-melanocyte-stimulating hormone-enhanced melanogenesis were almost completely blocked by expressing a lipase activity-negative mutant, LN-PLD2, but not by LN-PLD1.	Tetradecanoylphorbol Acetate	15-18	phospholipase D1	Mus musculus	217-221
15147830-2	2004	Treatment with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) (16.2 nM) or interferon-gamma (IFN-gamma) (100 U/ml) induced phosphorylation of p44/42 MAPK.	Tetradecanoylphorbol Acetate	52-88	interferon induced protein 44	Homo sapiens	175-178
15209417-3	2004	A defined pattern of PS1 expression was observed during differentiation with both RA and the phorbol ester TPA.	Tetradecanoylphorbol Acetate	107-110	presenilin 1	Homo sapiens	21-24
15209417-5	2004	TPA gave an earlier and longer lasting increase in full-length PS1 levels.	Tetradecanoylphorbol Acetate	0-3	presenilin 1	Homo sapiens	63-66
15209417-9	2004	Increases in PS1 expression upon treatment with RA and TPA were blocked by treatment with cycloheximide, indicating a role of de-novo protein synthesis in this effect.	Tetradecanoylphorbol Acetate	55-58	presenilin 1	Homo sapiens	13-16
14729583-6	2004	In the same animal model, TPA treatment resulted in rapid activation via phosphorylation of extracellular signal-regulated protein kinase (ERK)1/2 and p38 MAP kinase, which are upstream of AP-1 in mouse skin.	Tetradecanoylphorbol Acetate	26-29	mitogen-activated protein kinase 3	Mus musculus	92-146
14729583-6	2004	In the same animal model, TPA treatment resulted in rapid activation via phosphorylation of extracellular signal-regulated protein kinase (ERK)1/2 and p38 MAP kinase, which are upstream of AP-1 in mouse skin.	Tetradecanoylphorbol Acetate	26-29	mitogen-activated protein kinase 14	Mus musculus	151-154
14729583-6	2004	In the same animal model, TPA treatment resulted in rapid activation via phosphorylation of extracellular signal-regulated protein kinase (ERK)1/2 and p38 MAP kinase, which are upstream of AP-1 in mouse skin.	Tetradecanoylphorbol Acetate	26-29	jun proto-oncogene	Mus musculus	189-193
14729583-7	2004	In order to clarify the roles of p38 and ERK in TPA-induced AP-1 activation, we utilized the pharmacologic inhibitors of these enzymes.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 14	Mus musculus	33-36
14729583-7	2004	In order to clarify the roles of p38 and ERK in TPA-induced AP-1 activation, we utilized the pharmacologic inhibitors of these enzymes.	Tetradecanoylphorbol Acetate	48-51	jun proto-oncogene	Mus musculus	60-64
14729583-8	2004	The p38 inhibitor SB203580 blocked TPA-mediated AP-1 activation, while the MEK1/2 inhibitor U0126 was not inhibitory despite suppression of c-Fos expression in mouse skin.	Tetradecanoylphorbol Acetate	35-38	mitogen-activated protein kinase 14	Mus musculus	4-7
14729583-8	2004	The p38 inhibitor SB203580 blocked TPA-mediated AP-1 activation, while the MEK1/2 inhibitor U0126 was not inhibitory despite suppression of c-Fos expression in mouse skin.	Tetradecanoylphorbol Acetate	35-38	jun proto-oncogene	Mus musculus	48-52
14711835-7	2004	PTD-p65-P1 suppressed NF-kappaB activation induced by lipopolysaccharide, interleukin-1, okadaic acid, phorbol 12-myristate 13-acetate, H(2)O(2), and cigarette smoke condensate as well as that induced by TNF.	Tetradecanoylphorbol Acetate	103-134	RELA proto-oncogene, NF-kB subunit	Homo sapiens	4-7
15037572-9	2004	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased nuclear AP1 factor level and binding to the hINV gene AP1-1 response element.	Tetradecanoylphorbol Acetate	15-51	inversin	Homo sapiens	99-103
15037572-9	2004	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased nuclear AP1 factor level and binding to the hINV gene AP1-1 response element.	Tetradecanoylphorbol Acetate	15-51	inversin	Homo sapiens	207-211
15037572-9	2004	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased nuclear AP1 factor level and binding to the hINV gene AP1-1 response element.	Tetradecanoylphorbol Acetate	53-56	inversin	Homo sapiens	99-103
15037572-9	2004	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased nuclear AP1 factor level and binding to the hINV gene AP1-1 response element.	Tetradecanoylphorbol Acetate	53-56	inversin	Homo sapiens	207-211
15037572-10	2004	Expression of the endogenous hINV gene is also increased by TPA treatment.	Tetradecanoylphorbol Acetate	60-63	inversin	Homo sapiens	29-33
15041417-0	2004	Phorbol myristate acetate induces changes on F-actin and vinculin content in immature rat Sertoli cells.	Tetradecanoylphorbol Acetate	0-25	vinculin	Rattus norvegicus	57-65
15041417-2	2004	It has been well established that long-term exposure to the tumor promoter phorbol myristate acetate (PMA) affects Sertoli cell morphology, as well as F-actin and vinculin organization in vitro.	Tetradecanoylphorbol Acetate	75-100	vinculin	Rattus norvegicus	163-171
15041417-3	2004	To analyze in a quantitative manner the F-actin and vinculin content of rat immature Sertoli cells in vitro in response to PMA exposure, cytoskeletal fractions were prepared following extraction with Triton X-100.	Tetradecanoylphorbol Acetate	123-126	vinculin	Rattus norvegicus	52-60
14670076-9	2004	In addition, rat embryo fibroblasts overexpressing syndecan-4 exhibited a slowed down-regulation of PKC-alpha in response either to a prolonged treatment with PMA or to maintaining cells in suspension culture.	Tetradecanoylphorbol Acetate	159-162	syndecan 4	Rattus norvegicus	51-61
14633657-2	2004	In the present work, we assessed the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on expression of iNOS and COX-2 in mouse skin.	Tetradecanoylphorbol Acetate	48-84	prostaglandin-endoperoxide synthase 2	Mus musculus	117-122
14633657-2	2004	In the present work, we assessed the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on expression of iNOS and COX-2 in mouse skin.	Tetradecanoylphorbol Acetate	86-89	prostaglandin-endoperoxide synthase 2	Mus musculus	117-122
14633657-3	2004	Topical application to the dorsal skin of female ICR mice of 10 nmol TPA led to maximal induction of iNOS and COX-2 protein expression at approximately 2 and 4 h, respectively.	Tetradecanoylphorbol Acetate	69-72	prostaglandin-endoperoxide synthase 2	Mus musculus	110-115
14633657-5	2004	Pretreatment with a more specific iNOS inhibitor, N(G)-nitro-l-arginine-methyl ester, also suppressed TPA-induced COX-2 expression.	Tetradecanoylphorbol Acetate	102-105	prostaglandin-endoperoxide synthase 2	Mus musculus	114-119
15107555-1	2004	A pig interleukin-21 (IL-21) cDNA was successfully cloned and sequenced from porcine peripheral blood lymphocytes (PBL) stimulated with 10 microg/ml concanavalin A (ConA), 10 microg/ml phytohemagglutinin P (PHA), 50 ng/ml phorbol 12-myristate 13-acetate (PMA), and 0.5 microg/ml anti-porcine CD3 antibody for 48 hr.	Tetradecanoylphorbol Acetate	222-253	interleukin 21	Sus scrofa	6-20
15107555-1	2004	A pig interleukin-21 (IL-21) cDNA was successfully cloned and sequenced from porcine peripheral blood lymphocytes (PBL) stimulated with 10 microg/ml concanavalin A (ConA), 10 microg/ml phytohemagglutinin P (PHA), 50 ng/ml phorbol 12-myristate 13-acetate (PMA), and 0.5 microg/ml anti-porcine CD3 antibody for 48 hr.	Tetradecanoylphorbol Acetate	222-253	interleukin 21	Sus scrofa	22-27
15107555-1	2004	A pig interleukin-21 (IL-21) cDNA was successfully cloned and sequenced from porcine peripheral blood lymphocytes (PBL) stimulated with 10 microg/ml concanavalin A (ConA), 10 microg/ml phytohemagglutinin P (PHA), 50 ng/ml phorbol 12-myristate 13-acetate (PMA), and 0.5 microg/ml anti-porcine CD3 antibody for 48 hr.	Tetradecanoylphorbol Acetate	255-258	interleukin 21	Sus scrofa	6-20
15107555-1	2004	A pig interleukin-21 (IL-21) cDNA was successfully cloned and sequenced from porcine peripheral blood lymphocytes (PBL) stimulated with 10 microg/ml concanavalin A (ConA), 10 microg/ml phytohemagglutinin P (PHA), 50 ng/ml phorbol 12-myristate 13-acetate (PMA), and 0.5 microg/ml anti-porcine CD3 antibody for 48 hr.	Tetradecanoylphorbol Acetate	255-258	interleukin 21	Sus scrofa	22-27
14699063-5	2004	Knockdown of either Rac1 or IQGAP1 accelerated the 12-O-tetradecanoylphorbol-13-acetate-induced cell-cell dissociation.	Tetradecanoylphorbol Acetate	51-87	Rac family small GTPase 1	Canis lupus familiaris	20-24
14967736-7	2004	Electrophoretic mobility shift assay revealed that fenofibrate significantly decreased the ET-1-stimulated or phorbol 12-myristate 13-acetate-stimulated AP-1 DNA binding activity, and the nuclear extract probe complex was supershifted by anti-c-Jun antibody.	Tetradecanoylphorbol Acetate	110-141	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	153-157
14977846-8	2004	E7820 reduced integrin alpha2 expression on a megakaryocytic cell line, Dami cells, induced by phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	95-126	integrin subunit alpha 2	Homo sapiens	14-29
14627710-2	2004	JDP2 can bind 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive element and cAMP-responsive element DNA response elements, resulting in the inhibition of transcription.	Tetradecanoylphorbol Acetate	14-50	Jun dimerization protein 2	Mus musculus	0-4
14627710-2	2004	JDP2 can bind 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive element and cAMP-responsive element DNA response elements, resulting in the inhibition of transcription.	Tetradecanoylphorbol Acetate	52-55	Jun dimerization protein 2	Mus musculus	0-4
14741711-5	2004	Furthermore, PP2, a specific inhibitor of Src-family tyrosine kinases (PTKs), was found to inhibit both pervanadate-induced reverse translocation and tyrosine phosphorylation of PMA-stimulated PKCbetaII, suggesting that these two pervanadate-induced responses are mediated by Src-family PTKs.	Tetradecanoylphorbol Acetate	178-181	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	13-16
13679307-3	2004	Our goal was to reveal isoform-specific PKC activity in the microvascular endothelium in response to phorbol 12-myristate 13-acetate (PMA) and diacylglycerol (DAG).	Tetradecanoylphorbol Acetate	101-132	protein kinase C delta	Homo sapiens	40-43
13679307-3	2004	Our goal was to reveal isoform-specific PKC activity in the microvascular endothelium in response to phorbol 12-myristate 13-acetate (PMA) and diacylglycerol (DAG).	Tetradecanoylphorbol Acetate	134-137	protein kinase C delta	Homo sapiens	40-43
14725904-9	2004	Furthermore, long-term preincubation with bryostatin-1 or TPA, both of which are known to down-regulate PKC protein levels, likewise inhibited treosulfan-induced apoptosis.	Tetradecanoylphorbol Acetate	58-61	protein kinase C delta	Homo sapiens	104-107
14527959-7	2003	Pretreatment with the PKC delta-selective inhibitor rottlerin or transfection with an antisense PKC delta oligonucleotide inhibited PMA-induced cIAP-2 expression, whereas cotransfection with a PKC delta plasmid induced cIAP-2 promoter activity, which, taken together, identifies a role for PKC delta in cIAP-2 induction.	Tetradecanoylphorbol Acetate	132-135	protein kinase C delta	Homo sapiens	22-31
14527959-7	2003	Pretreatment with the PKC delta-selective inhibitor rottlerin or transfection with an antisense PKC delta oligonucleotide inhibited PMA-induced cIAP-2 expression, whereas cotransfection with a PKC delta plasmid induced cIAP-2 promoter activity, which, taken together, identifies a role for PKC delta in cIAP-2 induction.	Tetradecanoylphorbol Acetate	132-135	protein kinase C delta	Homo sapiens	96-105
14527959-7	2003	Pretreatment with the PKC delta-selective inhibitor rottlerin or transfection with an antisense PKC delta oligonucleotide inhibited PMA-induced cIAP-2 expression, whereas cotransfection with a PKC delta plasmid induced cIAP-2 promoter activity, which, taken together, identifies a role for PKC delta in cIAP-2 induction.	Tetradecanoylphorbol Acetate	132-135	protein kinase C delta	Homo sapiens	96-105
14527959-7	2003	Pretreatment with the PKC delta-selective inhibitor rottlerin or transfection with an antisense PKC delta oligonucleotide inhibited PMA-induced cIAP-2 expression, whereas cotransfection with a PKC delta plasmid induced cIAP-2 promoter activity, which, taken together, identifies a role for PKC delta in cIAP-2 induction.	Tetradecanoylphorbol Acetate	132-135	protein kinase C delta	Homo sapiens	96-105
14522966-5	2003	Activation of ERK1/2 by pretreatment with phorbol 12-myristate 13-acetate or forced expression of ERK1/2 attenuated phytosphingosine-induced caspase-8 activation.	Tetradecanoylphorbol Acetate	42-73	caspase 8	Homo sapiens	141-150
14580393-9	2003	Further GAS with tPA-activated plasminogen bound on their surface penetrated through Transwell-grown pharyngeal cells in significantly higher numbers.	Tetradecanoylphorbol Acetate	17-20	plasminogen	Homo sapiens	31-42
14623285-6	2003	Taken together, our data suggest that the synergistic activation of Raf-1 kinase in response to PMA and H(2)O(2) occurs via mechanisms that involve an interaction of Raf-1 kinase and PKC-epsilon, along with a transient phosphorylation of both Raf-1 kinase and PKC.	Tetradecanoylphorbol Acetate	96-99	protein kinase C, epsilon	Mus musculus	183-194
14623285-6	2003	Taken together, our data suggest that the synergistic activation of Raf-1 kinase in response to PMA and H(2)O(2) occurs via mechanisms that involve an interaction of Raf-1 kinase and PKC-epsilon, along with a transient phosphorylation of both Raf-1 kinase and PKC.	Tetradecanoylphorbol Acetate	96-99	protein kinase C, epsilon	Mus musculus	183-186
14522138-4	2003	Treatment with phorbol myristate acetate (PMA) induces respiratory burst in HTC cells and the secretion of matrix metalloproteinase (MMP) into culture medium.	Tetradecanoylphorbol Acetate	15-40	matrix metallopeptidase 2	Homo sapiens	133-136
14522138-4	2003	Treatment with phorbol myristate acetate (PMA) induces respiratory burst in HTC cells and the secretion of matrix metalloproteinase (MMP) into culture medium.	Tetradecanoylphorbol Acetate	42-45	matrix metallopeptidase 2	Homo sapiens	133-136
14565935-5	2003	Thus, whereas CsA and FK506 strongly enhanced TCR- and phorbol myristate acetate-induced LAT expression in T cells, rapamycin effectively inhibited activation-induced LAT expression.	Tetradecanoylphorbol Acetate	55-80	linker for activation of T cells	Homo sapiens	89-92
14708597-8	2003	The constitutive expression of MMP-19 was upregulated with phorbol myristate acetate and downregulated with retinoic acid and dexamethasone.	Tetradecanoylphorbol Acetate	59-84	matrix metallopeptidase 19	Homo sapiens	31-37
14559850-2	2003	We reported that FVB/N transgenic mice that overexpress ( approximately 18-fold) PKCepsilon protein in basal epidermal cells and cells of the hair follicle develop papilloma-independent metastatic squamous cell carcinoma (mSCC) elicited by 7,12-dimethylbenz(a)anthracene-initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promotion protocol.	Tetradecanoylphorbol Acetate	286-322	protein kinase C, epsilon	Mus musculus	81-91
14559850-2	2003	We reported that FVB/N transgenic mice that overexpress ( approximately 18-fold) PKCepsilon protein in basal epidermal cells and cells of the hair follicle develop papilloma-independent metastatic squamous cell carcinoma (mSCC) elicited by 7,12-dimethylbenz(a)anthracene-initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promotion protocol.	Tetradecanoylphorbol Acetate	324-327	protein kinase C, epsilon	Mus musculus	81-91
14559850-3	2003	We now present that PKCepsilon transgenic mice elicit elevated serum tumor necrosis factor (TNF)alpha levels during skin tumor promotion by TPA, and this increase may be linked to the development of mSCC.	Tetradecanoylphorbol Acetate	140-143	protein kinase C, epsilon	Mus musculus	20-30
14559850-4	2003	A single topical application of TPA (5 nmol) to the skin, as early as 2.5 h after treatment, resulted in a significant (P &lt; 0.01) increase (2-fold) in epidermal TNFalpha and more than a 6-fold increase in ectodomain shedding of TNFalpha into the serum of PKCepsilon transgenic mice relative to their wild-type littermates.	Tetradecanoylphorbol Acetate	32-35	protein kinase C, epsilon	Mus musculus	258-268
14559850-5	2003	Furthermore, this TPA-stimulated TNFalpha shedding was proportional to the level of expression of PKCepsilon in the epidermis.	Tetradecanoylphorbol Acetate	18-21	protein kinase C, epsilon	Mus musculus	98-108
14559850-6	2003	Using the TNF-alpha converting enzyme (TACE) inhibitor, TAPI-1, TPA-stimulated TNFalpha shedding could be completely prevented in PKCepsilon transgenic mice and isolated keratinocytes.	Tetradecanoylphorbol Acetate	64-67	protein kinase C, epsilon	Mus musculus	130-140
14559850-7	2003	These results indicate that PKCepsilon signal transduction pathways to TPA-stimulated TNFalpha ectodomain shedding are mediated by TACE, a transmembrane metalloprotease.	Tetradecanoylphorbol Acetate	71-74	protein kinase C, epsilon	Mus musculus	28-38
14559850-8	2003	Using the superoxide dismutase mimetic CuDIPs and the glutathione reductase mimetic ebselen, TPA-stimulated TNFalpha shedding from PKCepsilon transgenic mice could be completely attenuated, implying the role of reactive oxygen species.	Tetradecanoylphorbol Acetate	93-96	protein kinase C, epsilon	Mus musculus	131-141
14559850-11	2003	Taken together, these results indicate that: (a) PKCepsilon activation is an initial signal in TPA-induced shedding of TNFalpha from epidermal keratinocytes; (b) PKCepsilon-mediated signals to TACE are possibly mediated through reactive oxygen species; and (c) TPA-induced TNFalpha shedding may play a role in the development of mSCC in PKCepsilon transgenic mice.	Tetradecanoylphorbol Acetate	95-98	protein kinase C, epsilon	Mus musculus	49-59
15292277-2	2004	Here, we show that SHP expression increases during monocytic differentiaton with exposure HL-60 leukemia cells to a 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, whose treatment induced the SHP promoter activity dependent on c-Jun expression, which is well known to be involved in the commitment step in the TPA-induced differentiation of HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	116-152	nuclear receptor subfamily 0 group B member 2	Homo sapiens	19-22
15292277-2	2004	Here, we show that SHP expression increases during monocytic differentiaton with exposure HL-60 leukemia cells to a 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, whose treatment induced the SHP promoter activity dependent on c-Jun expression, which is well known to be involved in the commitment step in the TPA-induced differentiation of HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	116-152	nuclear receptor subfamily 0 group B member 2	Homo sapiens	205-208
15292277-2	2004	Here, we show that SHP expression increases during monocytic differentiaton with exposure HL-60 leukemia cells to a 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, whose treatment induced the SHP promoter activity dependent on c-Jun expression, which is well known to be involved in the commitment step in the TPA-induced differentiation of HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	154-157	nuclear receptor subfamily 0 group B member 2	Homo sapiens	19-22
15292277-2	2004	Here, we show that SHP expression increases during monocytic differentiaton with exposure HL-60 leukemia cells to a 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, whose treatment induced the SHP promoter activity dependent on c-Jun expression, which is well known to be involved in the commitment step in the TPA-induced differentiation of HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	154-157	nuclear receptor subfamily 0 group B member 2	Homo sapiens	205-208
15292277-2	2004	Here, we show that SHP expression increases during monocytic differentiaton with exposure HL-60 leukemia cells to a 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, whose treatment induced the SHP promoter activity dependent on c-Jun expression, which is well known to be involved in the commitment step in the TPA-induced differentiation of HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	323-326	nuclear receptor subfamily 0 group B member 2	Homo sapiens	19-22
15292277-2	2004	Here, we show that SHP expression increases during monocytic differentiaton with exposure HL-60 leukemia cells to a 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, whose treatment induced the SHP promoter activity dependent on c-Jun expression, which is well known to be involved in the commitment step in the TPA-induced differentiation of HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	323-326	nuclear receptor subfamily 0 group B member 2	Homo sapiens	205-208
15292277-4	2004	Electrophoretic mobility shift assays using oligonucleotides derived from the SHP promoter reveal that c-Jun exhibit TPA-induced DNA binding, providing a mechanism for the transcriptional activation of SHP gene expression.	Tetradecanoylphorbol Acetate	117-120	nuclear receptor subfamily 0 group B member 2	Homo sapiens	78-81
15292277-4	2004	Electrophoretic mobility shift assays using oligonucleotides derived from the SHP promoter reveal that c-Jun exhibit TPA-induced DNA binding, providing a mechanism for the transcriptional activation of SHP gene expression.	Tetradecanoylphorbol Acetate	117-120	nuclear receptor subfamily 0 group B member 2	Homo sapiens	202-205
15292277-5	2004	It was also found that overexpression of SHP and c-Jun greatly facilitated monocytic differentiation by TPA and surprisingly, that expression of SHP or c-Jun alone was sufficient to make cells differentiate into functionally mature monocytes, but silencing of SHP and c-Jun by RNA interference diminished the TPA-induced monocytic differentiation.	Tetradecanoylphorbol Acetate	104-107	nuclear receptor subfamily 0 group B member 2	Homo sapiens	41-44
15292277-5	2004	It was also found that overexpression of SHP and c-Jun greatly facilitated monocytic differentiation by TPA and surprisingly, that expression of SHP or c-Jun alone was sufficient to make cells differentiate into functionally mature monocytes, but silencing of SHP and c-Jun by RNA interference diminished the TPA-induced monocytic differentiation.	Tetradecanoylphorbol Acetate	309-312	nuclear receptor subfamily 0 group B member 2	Homo sapiens	41-44
15482487-4	2004	Here, we report that K10(-/-) mice treated with 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) developed far less papillomas than wild-type mice.	Tetradecanoylphorbol Acetate	86-122	keratin 10	Mus musculus	21-24
15482487-4	2004	Here, we report that K10(-/-) mice treated with 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) developed far less papillomas than wild-type mice.	Tetradecanoylphorbol Acetate	124-127	keratin 10	Mus musculus	21-24
15488737-3	2004	In addition, we showed that this induction is mediated by the PKC pathway: in the presence of Ro 31-8220, an inhibitor of all PKC isozymes, or after 48 h of PMA treatment, Tat protein becomes unable to stimulate IL-10 production.	Tetradecanoylphorbol Acetate	157-160	tyrosine aminotransferase	Homo sapiens	172-175
15557817-6	2004	Phorbol 12-myristate 13-acetate (PMA), which is known to activate PKC, stimulated PLD activity significantly more in the core protein-transformed cells, in comparison with that of the control cells.	Tetradecanoylphorbol Acetate	0-31	protein kinase C delta	Homo sapiens	66-69
15373836-0	2004	Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4 beta-phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	118-156	mitogen activated protein kinase 3	Rattus norvegicus	40-86
15215246-4	2004	Transmembrane IL-15Ralpha is constitutively converted into its soluble form by proteolytic cleavage that involves tumor necrosis factor-alpha-converting enzyme (TACE), and this process is further enhanced by phorbol 12-myristate 13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	208-239	interleukin 15 receptor, alpha chain	Mus musculus	14-25
15215246-4	2004	Transmembrane IL-15Ralpha is constitutively converted into its soluble form by proteolytic cleavage that involves tumor necrosis factor-alpha-converting enzyme (TACE), and this process is further enhanced by phorbol 12-myristate 13-acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	241-244	interleukin 15 receptor, alpha chain	Mus musculus	14-25
15385801-9	2004	Interestingly, an additive inhibition between B1 and tacrolimus (FK506) was found in the CD69 expression stimulated by PMA/CD28 and PMA/ionomycin.	Tetradecanoylphorbol Acetate	119-122	Cd28 molecule	Rattus norvegicus	123-127
15313406-4	2004	Our results provide evidence for a differential effect of chemopreventive agents such as beta-lapachone, emodin, sanguinarine and capsaicin, which significantly inhibit reporter gene expression as well as TNFalpha- and TPA-induced binding of AP-1 and NF-kappaB, whereas trans-anethole and silymarin do not produce any inhibitory effect.	Tetradecanoylphorbol Acetate	219-222	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	242-246
15302583-8	2004	In summary, TPA-induced TIS21 mRNA expression is mediated by PKC-delta, and TIS21 induces G2/M arrest and cell death by inhibiting cyclin B1-Cdc2 binding and the kinase activity through its binding to Cdc2.	Tetradecanoylphorbol Acetate	12-15	protein kinase C delta	Homo sapiens	61-70
15331751-1	2004	TPA (12-O-tetradecanoylphorbol-13-acetate), a well-known activator of protein kinase C (PKC), can experimentally induce reactivation of Kaposi"s sarcoma-associated herpesvirus (KSHV) in certain latently infected cells.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	88-91
15331751-1	2004	TPA (12-O-tetradecanoylphorbol-13-acetate), a well-known activator of protein kinase C (PKC), can experimentally induce reactivation of Kaposi"s sarcoma-associated herpesvirus (KSHV) in certain latently infected cells.	Tetradecanoylphorbol Acetate	5-41	protein kinase C delta	Homo sapiens	88-91
15331751-2	2004	We selectively blocked the activity of PKC isoforms by using GF 109203X or rottlerin and demonstrated that this inhibition largely decreased lytic KSHV reactivation by TPA.	Tetradecanoylphorbol Acetate	168-171	protein kinase C delta	Homo sapiens	39-42
15331751-3	2004	Translocation of the PKCdelta isoform was evident shortly after TPA stimulation.	Tetradecanoylphorbol Acetate	64-67	protein kinase C delta	Homo sapiens	21-29
15460057-11	2004	During the regenerated course, PMA can promote the expression of NGF mRNA and the number of axons after injury.	Tetradecanoylphorbol Acetate	31-34	nerve growth factor	Rattus norvegicus	65-68
15328001-2	2004	AMPK activated with either 5"-aminoimidazole-4-carboxamide ribonucleoside (AICAR) or with 5"-AMP significantly attenuated both phorbol 12-myristate 13-acetate (PMA) and formyl methionyl leucyl phenylalanine-stimulated superoxide anion O2- release by human neutrophils, consistently with a reduced translocation to the cell membrane and phosphorylation of a cytosolic component of NADPH oxidase, namely p47phox.	Tetradecanoylphorbol Acetate	127-158	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-4
15328001-2	2004	AMPK activated with either 5"-aminoimidazole-4-carboxamide ribonucleoside (AICAR) or with 5"-AMP significantly attenuated both phorbol 12-myristate 13-acetate (PMA) and formyl methionyl leucyl phenylalanine-stimulated superoxide anion O2- release by human neutrophils, consistently with a reduced translocation to the cell membrane and phosphorylation of a cytosolic component of NADPH oxidase, namely p47phox.	Tetradecanoylphorbol Acetate	127-158	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	75-80
15328001-2	2004	AMPK activated with either 5"-aminoimidazole-4-carboxamide ribonucleoside (AICAR) or with 5"-AMP significantly attenuated both phorbol 12-myristate 13-acetate (PMA) and formyl methionyl leucyl phenylalanine-stimulated superoxide anion O2- release by human neutrophils, consistently with a reduced translocation to the cell membrane and phosphorylation of a cytosolic component of NADPH oxidase, namely p47phox.	Tetradecanoylphorbol Acetate	160-163	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-4
15328001-2	2004	AMPK activated with either 5"-aminoimidazole-4-carboxamide ribonucleoside (AICAR) or with 5"-AMP significantly attenuated both phorbol 12-myristate 13-acetate (PMA) and formyl methionyl leucyl phenylalanine-stimulated superoxide anion O2- release by human neutrophils, consistently with a reduced translocation to the cell membrane and phosphorylation of a cytosolic component of NADPH oxidase, namely p47phox.	Tetradecanoylphorbol Acetate	160-163	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	75-80
15328001-4	2004	Furthermore, AICAR also strongly reduced PMA-dependent H2O2 release, and induced the phosphorylation of c-jun N-terminal kinase 1 (p46), p38 mitogen-activated protein kinase and extracellular signal-regulated kinase.	Tetradecanoylphorbol Acetate	41-44	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	13-18
15212812-5	2004	PD98059 inhibited PGE2 production stimulated by PMA as well as Cd, indicating that activation of PKC by ERK1/2 MAPK was necessary for Cd-stimulated PGE2 production.	Tetradecanoylphorbol Acetate	48-51	mitogen-activated protein kinase 3	Mus musculus	104-110
15087429-5	2004	Forskolin (FSK), an adenylate cyclase inducer, 8-bromo-cAMP, a cAMP analog, and phorbol myristate acetate, a PKC activator, increased E4bp4 mRNA levels, whereas ionomycin, a calcium ionophore, had no effect.	Tetradecanoylphorbol Acetate	80-105	nuclear factor, interleukin 3, regulated	Mus musculus	134-139
15155804-3	2004	We investigated the function of PV1 within these diaphragms and their regulation and found that treatment of endothelial cells in culture with phorbol myristate acetate (PMA) led to upregulation of PV1.	Tetradecanoylphorbol Acetate	143-168	plasmalemma vesicle associated protein	Homo sapiens	32-35
15155804-3	2004	We investigated the function of PV1 within these diaphragms and their regulation and found that treatment of endothelial cells in culture with phorbol myristate acetate (PMA) led to upregulation of PV1.	Tetradecanoylphorbol Acetate	143-168	plasmalemma vesicle associated protein	Homo sapiens	198-201
15155804-3	2004	We investigated the function of PV1 within these diaphragms and their regulation and found that treatment of endothelial cells in culture with phorbol myristate acetate (PMA) led to upregulation of PV1.	Tetradecanoylphorbol Acetate	170-173	plasmalemma vesicle associated protein	Homo sapiens	32-35
15155804-3	2004	We investigated the function of PV1 within these diaphragms and their regulation and found that treatment of endothelial cells in culture with phorbol myristate acetate (PMA) led to upregulation of PV1.	Tetradecanoylphorbol Acetate	170-173	plasmalemma vesicle associated protein	Homo sapiens	198-201
15282324-3	2004	We report here that CCND1 promoter activation by estrogens in human breast cancer cells is mediated by recruitment of a c-Jun/c-Fos/estrogen receptor alpha complex to the tetradecanoyl phorbol acetate-responsive element of the gene, together with Oct-1 to a site immediately adjacent.	Tetradecanoylphorbol Acetate	171-200	cyclin D1	Homo sapiens	20-25
15184881-4	2004	However, in cultured prostate cancer cells, the REPS2-p65 interaction is triggered upon stimulation with phorbol ester (PMA).	Tetradecanoylphorbol Acetate	120-123	RELA proto-oncogene, NF-kB subunit	Homo sapiens	54-57
15210597-5	2004	Phorbol 12-myristate 13-acetate, a potent activator of PKC, mimicked the effect of high glucose on VCAM-1 expression.	Tetradecanoylphorbol Acetate	0-31	protein kinase C beta	Homo sapiens	55-58
15087454-2	2004	We have reported that NF-kappaB is essential but not sufficient for the synergistic induction of MnSOD by phorbol 12-myristate 13-acetate and cytokines.	Tetradecanoylphorbol Acetate	106-137	superoxide dismutase 2	Homo sapiens	97-102
15087454-10	2004	These results identify NPM as a partner of the NF-kappaB transcription complex in the induction of MnSOD by phorbol 12-myristate 13-acetate and cytokines.	Tetradecanoylphorbol Acetate	108-139	nucleophosmin 1	Homo sapiens	23-26
15087454-10	2004	These results identify NPM as a partner of the NF-kappaB transcription complex in the induction of MnSOD by phorbol 12-myristate 13-acetate and cytokines.	Tetradecanoylphorbol Acetate	108-139	superoxide dismutase 2	Homo sapiens	99-104
15242943-8	2004	As already described for more conventional techniques, we showed that certain genes, such as those for CD40, gamma interferon, interleukin 2 (IL-2), the IL-2 receptor, and tumor necrosis factor alpha, were upregulated in PMA-Iono-stimulated PBMCs.	Tetradecanoylphorbol Acetate	221-224	CD40 molecule	Sus scrofa	103-107
15280448-3	2004	Our results demonstrate that IL-10 significantly inhibited MMP-2 transcription and protein expression induced by a phorbol ester, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	130-161	matrix metallopeptidase 2	Homo sapiens	59-64
15075332-1	2004	Previous studies indicated that treatment of cells with 12-O-tetradecanoylphorbol-13-acetate induced phosphorylation of Ser-985 at the juxtamembrane of c-Met, the receptor tyrosine kinase for hepatocyte growth factor (HGF), and this was associated with decreased tyrosine phosphorylation of c-Met.	Tetradecanoylphorbol Acetate	56-92	hepatocyte growth factor	Homo sapiens	192-216
15075332-1	2004	Previous studies indicated that treatment of cells with 12-O-tetradecanoylphorbol-13-acetate induced phosphorylation of Ser-985 at the juxtamembrane of c-Met, the receptor tyrosine kinase for hepatocyte growth factor (HGF), and this was associated with decreased tyrosine phosphorylation of c-Met.	Tetradecanoylphorbol Acetate	56-92	hepatocyte growth factor	Homo sapiens	218-221
15195298-4	2004	In all compounds, we find a strongly TPA-active A(g) state (either 2A(g) or 3A(g)) in the low-energy region, as well as a higher lying TPA-active state (mA(g)) at close to twice the energy of the lowest lying one-photon allowed state; the smaller energy detuning in the mA(g) states results in very large TPA cross sections delta.	Tetradecanoylphorbol Acetate	37-40	myelin-associated glycoprotein	Mus musculus	48-52
15195298-4	2004	In all compounds, we find a strongly TPA-active A(g) state (either 2A(g) or 3A(g)) in the low-energy region, as well as a higher lying TPA-active state (mA(g)) at close to twice the energy of the lowest lying one-photon allowed state; the smaller energy detuning in the mA(g) states results in very large TPA cross sections delta.	Tetradecanoylphorbol Acetate	135-138	myelin-associated glycoprotein	Mus musculus	153-158
15195298-4	2004	In all compounds, we find a strongly TPA-active A(g) state (either 2A(g) or 3A(g)) in the low-energy region, as well as a higher lying TPA-active state (mA(g)) at close to twice the energy of the lowest lying one-photon allowed state; the smaller energy detuning in the mA(g) states results in very large TPA cross sections delta.	Tetradecanoylphorbol Acetate	135-138	myelin-associated glycoprotein	Mus musculus	153-158
14976056-7	2004	Stored Ang-2 has a long half-life of more than 18 hours and can be secreted within minutes of stimulation (eg, by phorbol 12-myristate 13-acetate [PMA], thrombin, and histamine).	Tetradecanoylphorbol Acetate	114-145	angiopoietin 2	Homo sapiens	7-12
14976056-7	2004	Stored Ang-2 has a long half-life of more than 18 hours and can be secreted within minutes of stimulation (eg, by phorbol 12-myristate 13-acetate [PMA], thrombin, and histamine).	Tetradecanoylphorbol Acetate	147-150	angiopoietin 2	Homo sapiens	7-12
15527172-2	2004	Exposure of resting and phorbol-12-myristate-13-acetate (PMA) stimulated human neutrophils to potassium humate resulted in a decreased expression of CR3 by activated, but not resting cells, in a dose-related way.	Tetradecanoylphorbol Acetate	24-55	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	149-152
15527172-2	2004	Exposure of resting and phorbol-12-myristate-13-acetate (PMA) stimulated human neutrophils to potassium humate resulted in a decreased expression of CR3 by activated, but not resting cells, in a dose-related way.	Tetradecanoylphorbol Acetate	57-60	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	149-152
15527172-3	2004	Humate also inhibited the adhesion of PMA-stimulated neutrophils to a baby hamster kidney cell line expressing ICAM1 (the CR3 ligand) (BHK331-7).	Tetradecanoylphorbol Acetate	38-41	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	122-125
15169840-6	2004	PKC inhibition by chelerythrine chloride and myristoylated PKC pseudosubstrate, as well as PKC downregulation by PMA strongly reduce cytoskeleton-dependent ALCAM-mediated adhesion.	Tetradecanoylphorbol Acetate	113-116	activated leukocyte cell adhesion molecule	Homo sapiens	156-161
15118344-3	2004	YS 51 also showed synergistic effects on the induction of Mn-SOD mRNA with phorbol-12-myristate-13-acetate (TPA) and/or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	75-106	superoxide dismutase 2	Homo sapiens	58-64
15118344-3	2004	YS 51 also showed synergistic effects on the induction of Mn-SOD mRNA with phorbol-12-myristate-13-acetate (TPA) and/or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	108-111	superoxide dismutase 2	Homo sapiens	58-64
14978034-8	2004	Furthermore, co-treatment of AhR-deficient cells that expressed AhRY9F and a DRE-driven luciferase construct with phorbol 12-myristate 13-acetate and TCDD resulted in a 30% increase in luciferase activity compared with AhRY9F treated with TCDD alone.	Tetradecanoylphorbol Acetate	114-145	aryl hydrocarbon receptor	Homo sapiens	29-32
15115382-4	2004	A k(app) value in the 10(3) M(-1) s(-1) range for uPA was obtained, together with a selectivity index higher than 240 toward other trypsin-like proteases such as tPA, thrombin, plasmin, and FXa.	Tetradecanoylphorbol Acetate	162-165	plasminogen	Homo sapiens	177-184
14729583-4	2004	In another study, celecoxib attenuated the DNA binding activity of activator protein 1 (AP-1) through suppression of c-Jun and c-Fos expression in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	147-150	jun proto-oncogene	Mus musculus	67-86
14729583-4	2004	In another study, celecoxib attenuated the DNA binding activity of activator protein 1 (AP-1) through suppression of c-Jun and c-Fos expression in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	147-150	jun proto-oncogene	Mus musculus	88-92
14729583-4	2004	In another study, celecoxib attenuated the DNA binding activity of activator protein 1 (AP-1) through suppression of c-Jun and c-Fos expression in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	147-150	jun proto-oncogene	Mus musculus	117-122
14769799-4	2004	Phorbol 12-myristate 13-acetate (PMA)-stimulated but not resting neutrophils dissolved fibrin clots, and this activity was not only uPA- and Plg-dependent but also alpha(M)beta(2)-dependent.	Tetradecanoylphorbol Acetate	0-31	plasminogen	Homo sapiens	141-144
14769799-4	2004	Phorbol 12-myristate 13-acetate (PMA)-stimulated but not resting neutrophils dissolved fibrin clots, and this activity was not only uPA- and Plg-dependent but also alpha(M)beta(2)-dependent.	Tetradecanoylphorbol Acetate	33-36	plasminogen	Homo sapiens	141-144
15033458-3	2004	These regulations of I-Smads by TPA were suppressed by one PKC inhibitor (Go6983), but not by another (Go6976).	Tetradecanoylphorbol Acetate	32-35	protein kinase C delta	Homo sapiens	59-62
15081539-6	2004	Treating Pyst2-L transfected cells with known activators of the MAPK signaling cascade such as TPA or stimulating them by serum, it was demonstrated that the up regulation of phospho-Erk1/2, caused by these activators, was only partially suppressed by the over expression of the Pyst2-L phosphatase in these cells.	Tetradecanoylphorbol Acetate	95-98	dual specificity phosphatase 7	Homo sapiens	9-14
15081539-7	2004	These results together with our previous ones showing that the TPA-induced up regulation of Pyst2-L mRNA was only partially inhibited by the use of a specific Mek1/2 inhibitor, lead us to ask whether the Pyst2-L phosphatase has a monogamous relationship with the Erk2 protein.	Tetradecanoylphorbol Acetate	63-66	dual specificity phosphatase 7	Homo sapiens	92-97
15081539-7	2004	These results together with our previous ones showing that the TPA-induced up regulation of Pyst2-L mRNA was only partially inhibited by the use of a specific Mek1/2 inhibitor, lead us to ask whether the Pyst2-L phosphatase has a monogamous relationship with the Erk2 protein.	Tetradecanoylphorbol Acetate	63-66	dual specificity phosphatase 7	Homo sapiens	204-209
14711820-6	2004	We then identified a Sp1 binding site located -77 to -68 from the ATG that is a TPA-responsive element (TRE) of the promoter and that Sp1, Sp2, and Sp3 proteins bind to the TRE.	Tetradecanoylphorbol Acetate	80-83	trans-acting transcription factor 3	Mus musculus	148-151
14711820-8	2004	These data suggest that increased binding of Sp1, Sp2, and Sp3 to the TRE of the 8S-LOX promoter is a mechanism by which TPA induces 8S-LOX expression in keratinocytes.	Tetradecanoylphorbol Acetate	121-124	trans-acting transcription factor 3	Mus musculus	59-62
14630807-5	2004	In contrast, p300 was detectable in nucleus and its binding to a COX-2 promoter probe was enhanced by phorbol 12-myristate 13-acetate (PMA), interleukin-1 beta(IL-1 beta), or lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	102-133	E1A binding protein p300	Homo sapiens	13-17
14630807-5	2004	In contrast, p300 was detectable in nucleus and its binding to a COX-2 promoter probe was enhanced by phorbol 12-myristate 13-acetate (PMA), interleukin-1 beta(IL-1 beta), or lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	135-138	E1A binding protein p300	Homo sapiens	13-17
14679188-7	2004	In contrast, phorbol ester (PMA) treatment produced sustained increase in ACE mRNA and activity.	Tetradecanoylphorbol Acetate	28-31	angiotensin I converting enzyme	Bos taurus	74-77
14871478-3	2004	Increased basal oxidative stress in Ttpa(-/-) mice was documented by increased plasma lipid peroxidation, and superoxide production by bone marrow-derived neutrophils stimulated in vitro with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	192-223	tocopherol (alpha) transfer protein	Mus musculus	36-40
15005710-5	2004	Surprisingly, the c-Fos induced by the YXXQ-signal alone was localized to the cytoplasm, from which it translocated into the nucleus following TPA (12-O-tetradecanoyl-phorbol 13-acetate) treatment in a MEK/Erk-dependent manner.	Tetradecanoylphorbol Acetate	143-146	midkine	Mus musculus	202-205
15005710-5	2004	Surprisingly, the c-Fos induced by the YXXQ-signal alone was localized to the cytoplasm, from which it translocated into the nucleus following TPA (12-O-tetradecanoyl-phorbol 13-acetate) treatment in a MEK/Erk-dependent manner.	Tetradecanoylphorbol Acetate	148-185	midkine	Mus musculus	202-205
14757441-5	2004	Furthermore, when HL-60 myeloid leukemic cells were differentiated with phorbol ester (TPA), PBK/TOPK protein expression was strongly down-regulated by 24 h. Under these same conditions, phosphorylated c-Myc was rapidly down-regulated (by 4 h), while the levels of cyclin D1 and phosphorylated p38 were constant.	Tetradecanoylphorbol Acetate	87-90	cyclin D1	Homo sapiens	265-274
14630706-5	2004	In this study, we show that topical application of SC-560 (a COX-1 selective inhibitor) or celecoxib (COX-2 selective) to TPA-treated wild-type skin caused fivefold increases in the number of basal keratinocytes expressing the early differentiation marker keratin 1 (K1).	Tetradecanoylphorbol Acetate	122-125	cytochrome c oxidase II, mitochondrial	Mus musculus	102-107
14673171-4	2004	We report here that ATF-3, JunB, and BRG-1 (the ATPase subunit of the 2-MDa human chromatin remodeling machine SWI/SNF) are recruited to the 3" boundary of nuc-1 following phorbol myristate acetate stimulation in Jurkat T cells.	Tetradecanoylphorbol Acetate	172-197	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	37-42
14673177-2	2004	In response to phorbol 12-myristate 13-acetate (PMA), the CSF-1 receptor is subject to proteolytic processing.	Tetradecanoylphorbol Acetate	15-46	colony stimulating factor 1 receptor	Homo sapiens	58-72
14673177-2	2004	In response to phorbol 12-myristate 13-acetate (PMA), the CSF-1 receptor is subject to proteolytic processing.	Tetradecanoylphorbol Acetate	48-51	colony stimulating factor 1 receptor	Homo sapiens	58-72
14575865-2	2003	In this study, we show that PAK1 can be stimulated by carbachol, lysophosphatidic acid (LPA), epidermal growth factor (EGF), and phorbol 12-myristate 13-acetate (PMA) by multiple independent and overlapping pathways.	Tetradecanoylphorbol Acetate	129-160	p21 (RAC1) activated kinase 1	Homo sapiens	28-32
14575865-2	2003	In this study, we show that PAK1 can be stimulated by carbachol, lysophosphatidic acid (LPA), epidermal growth factor (EGF), and phorbol 12-myristate 13-acetate (PMA) by multiple independent and overlapping pathways.	Tetradecanoylphorbol Acetate	162-165	p21 (RAC1) activated kinase 1	Homo sapiens	28-32
14563393-11	2003	These changes in the expression of Cx43 induced by OBC were similar to those induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a tumor promoter.	Tetradecanoylphorbol Acetate	126-129	gap junction protein alpha 1	Homo sapiens	35-39
12921950-6	2003	Surprisingly, cyclin D1 expression was upregulated after induction by TPA, TNFalpha with IFNgamma or BA.	Tetradecanoylphorbol Acetate	70-73	cyclin D1	Homo sapiens	14-23
14559850-11	2003	Taken together, these results indicate that: (a) PKCepsilon activation is an initial signal in TPA-induced shedding of TNFalpha from epidermal keratinocytes; (b) PKCepsilon-mediated signals to TACE are possibly mediated through reactive oxygen species; and (c) TPA-induced TNFalpha shedding may play a role in the development of mSCC in PKCepsilon transgenic mice.	Tetradecanoylphorbol Acetate	95-98	protein kinase C, epsilon	Mus musculus	162-172
14559850-11	2003	Taken together, these results indicate that: (a) PKCepsilon activation is an initial signal in TPA-induced shedding of TNFalpha from epidermal keratinocytes; (b) PKCepsilon-mediated signals to TACE are possibly mediated through reactive oxygen species; and (c) TPA-induced TNFalpha shedding may play a role in the development of mSCC in PKCepsilon transgenic mice.	Tetradecanoylphorbol Acetate	95-98	protein kinase C, epsilon	Mus musculus	162-172
14559850-11	2003	Taken together, these results indicate that: (a) PKCepsilon activation is an initial signal in TPA-induced shedding of TNFalpha from epidermal keratinocytes; (b) PKCepsilon-mediated signals to TACE are possibly mediated through reactive oxygen species; and (c) TPA-induced TNFalpha shedding may play a role in the development of mSCC in PKCepsilon transgenic mice.	Tetradecanoylphorbol Acetate	261-264	protein kinase C, epsilon	Mus musculus	49-59
14559850-11	2003	Taken together, these results indicate that: (a) PKCepsilon activation is an initial signal in TPA-induced shedding of TNFalpha from epidermal keratinocytes; (b) PKCepsilon-mediated signals to TACE are possibly mediated through reactive oxygen species; and (c) TPA-induced TNFalpha shedding may play a role in the development of mSCC in PKCepsilon transgenic mice.	Tetradecanoylphorbol Acetate	261-264	protein kinase C, epsilon	Mus musculus	162-172
14559850-11	2003	Taken together, these results indicate that: (a) PKCepsilon activation is an initial signal in TPA-induced shedding of TNFalpha from epidermal keratinocytes; (b) PKCepsilon-mediated signals to TACE are possibly mediated through reactive oxygen species; and (c) TPA-induced TNFalpha shedding may play a role in the development of mSCC in PKCepsilon transgenic mice.	Tetradecanoylphorbol Acetate	261-264	protein kinase C, epsilon	Mus musculus	162-172
12959990-12	2003	Taking a step further to dissect the possible regulatory pathways involved, with the aid of phorbol 12-myristate 13-acetate or ionomycin, additive effects on STC gene expression were observed.	Tetradecanoylphorbol Acetate	92-123	stanniocalcin 1	Homo sapiens	158-161
12860017-5	2003	Besides the staurosporines, also 12-O-tetradecanoyl phorbol acetate (TPA) and tumor necrosis factor-alpha (TNFalpha) strongly increased the IL-8 and MCP-1 secretion of NB-4 cells.	Tetradecanoylphorbol Acetate	33-67	chemokine (C-X-C motif) ligand 15	Mus musculus	140-144
12860017-5	2003	Besides the staurosporines, also 12-O-tetradecanoyl phorbol acetate (TPA) and tumor necrosis factor-alpha (TNFalpha) strongly increased the IL-8 and MCP-1 secretion of NB-4 cells.	Tetradecanoylphorbol Acetate	69-72	chemokine (C-X-C motif) ligand 15	Mus musculus	140-144
12921950-9	2003	Quantitative RT-PCR showed as much as a 288-fold increase of cyclin D1 specific mRNA after a 24h induction by TPA.	Tetradecanoylphorbol Acetate	110-113	cyclin D1	Homo sapiens	61-70
15349752-4	2004	For experimentally induced tumor promotion, we investigated whether the SNL glycoprotein was able to regulate the activity of protein kinase C alpha (PKCalpha), the DNA binding activation of nuclear factor-kappa B (NF-kappaB), the activity of NF-kappaB protein, and the production of nitric oxide (NO) in HCT-116 cells stimulated with 12-O-tetradecanoylphorbol 13-acetate (TPA) using electrophoretic mobility shift assays (EMSA), Western blot analysis, and NO assays.	Tetradecanoylphorbol Acetate	373-376	fascin actin-bundling protein 1	Homo sapiens	72-75
12947046-3	2003	Interestingly, the same cis-acting motif was also found to be important for both the basal activity and phorbol 12-myristate 13-acetate responsiveness of the GnRHR promoter.	Tetradecanoylphorbol Acetate	104-135	gonadotropin releasing hormone receptor	Homo sapiens	158-163
15349752-5	2004	As expected, SNL glycoprotein dose-dependently inhibited PKCalpha translocation, NF-kappaB DNA binding activity, NF-kappaB protein activity and NO production in HCT-116 cells stimulated with TPA (61.68 ng/ml, 100 nM).	Tetradecanoylphorbol Acetate	191-194	fascin actin-bundling protein 1	Homo sapiens	13-16
14503869-3	2003	This study addresses the contribution of the C1A and C1B domains in the regulation of protein kinase C"s membrane interaction using bisfunctional (dimeric) phorbol myristate acetate (PMA) molecules.	Tetradecanoylphorbol Acetate	156-181	endogenous retrovirus group K member 1	Homo sapiens	45-48
14503869-3	2003	This study addresses the contribution of the C1A and C1B domains in the regulation of protein kinase C"s membrane interaction using bisfunctional (dimeric) phorbol myristate acetate (PMA) molecules.	Tetradecanoylphorbol Acetate	183-186	endogenous retrovirus group K member 1	Homo sapiens	45-48
15541021-1	2004	The purpose of the present study was to investigate the expression of matrix metalloproteinase (MMP)-2 and MMP-9 by cultured human uveal melanocytes, and to test the effects of 12-O-tetradecanoyl-phorbol-13-acetate on the expression of these MMPs.	Tetradecanoylphorbol Acetate	177-214	matrix metallopeptidase 2	Homo sapiens	242-246
12960059-8	2003	The phase 2 response was eliminated by removing extracellular free Ca2+, by verapamil, a voltage-gated Ca2+ channel blocker, or by 24-h pretreatment with phorbol 12-myristate 13-acetate, down-regulating protein kinase C. In isolated (denervated) heart, GHRP have a direct cardiotropic, without chronotropic, effect.	Tetradecanoylphorbol Acetate	154-185	growth hormone secretagogue receptor	Rattus norvegicus	253-257
15541021-4	2004	Addition of 12-O-tetradecanoyl-phorbol-13-acetate (10 ng/ml) to the culture medium caused an increase of production of MMP-2 and MMP-9 by cultured uveal melanocytes, and also stimulated the transcription of MMP-2 and MMP-9 of these cells.	Tetradecanoylphorbol Acetate	12-49	matrix metallopeptidase 2	Homo sapiens	119-124
15556684-3	2004	Using enzyme-linked immunosorbent assay, we measured unstimulated and concanavalin A/phorbol myristate acetate-stimulated production of interleukin-4 (IL-4), IL-5, IL-10, IL-13 and interferon- gamma (IFN-gamma) by decidual explants from 59 healthy women delivered by unlabored cesarean section and from corresponding CBMCs in 39 of the 59.	Tetradecanoylphorbol Acetate	85-110	interleukin 5	Homo sapiens	158-162
12824067-7	2003	In addition, the 17 kDa protein levels in THP-1 cells were transiently increased, concomitant with a decrease in the 23 kDa ubiquitinated H2A, by treatment with phorbol 12-myristate 13-acetate or all-trans-retinoic acid, both of which induce differentiation.	Tetradecanoylphorbol Acetate	161-192	H2A clustered histone 18	Homo sapiens	138-141
12972299-6	2003	Furthermore, we have analyzed the expression of versican isoforms in SK-mel-3.44 and SK-mel-1.36-1-5 cells induced to differentiate by TPA treatment.	Tetradecanoylphorbol Acetate	135-138	versican	Homo sapiens	48-56
12923217-3	2003	Activation of protein kinase C (PKC) by perfusion of hearts with phorbol-12-myristate-13-acetate (PMA) or endothelin-1 (ET-1) inhibited the maximum ATPase rate by up to 25 % and increased the Ca2+ sensitivity of ATPase activity and of isometric tension by up to 0.15 pCa units.	Tetradecanoylphorbol Acetate	65-96	dynein, axonemal, heavy chain 8	Mus musculus	148-154
12923217-3	2003	Activation of protein kinase C (PKC) by perfusion of hearts with phorbol-12-myristate-13-acetate (PMA) or endothelin-1 (ET-1) inhibited the maximum ATPase rate by up to 25 % and increased the Ca2+ sensitivity of ATPase activity and of isometric tension by up to 0.15 pCa units.	Tetradecanoylphorbol Acetate	65-96	dynein, axonemal, heavy chain 8	Mus musculus	212-218
12923217-3	2003	Activation of protein kinase C (PKC) by perfusion of hearts with phorbol-12-myristate-13-acetate (PMA) or endothelin-1 (ET-1) inhibited the maximum ATPase rate by up to 25 % and increased the Ca2+ sensitivity of ATPase activity and of isometric tension by up to 0.15 pCa units.	Tetradecanoylphorbol Acetate	98-101	dynein, axonemal, heavy chain 8	Mus musculus	148-154
15539760-0	2004	Expression of cytosolic phospholipase A2 alpha in murine C12 cells, a variant of L929 cells, induces arachidonic acid release in response to phorbol myristate acetate and Ca2+ ionophores, but not to tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	141-166	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	14-40
12923217-3	2003	Activation of protein kinase C (PKC) by perfusion of hearts with phorbol-12-myristate-13-acetate (PMA) or endothelin-1 (ET-1) inhibited the maximum ATPase rate by up to 25 % and increased the Ca2+ sensitivity of ATPase activity and of isometric tension by up to 0.15 pCa units.	Tetradecanoylphorbol Acetate	98-101	dynein, axonemal, heavy chain 8	Mus musculus	212-218
15501252-9	2004	These data suggest that structural elements responsible for COX-1 and COX-2 inhibition do not correlate well with those responsible for inhibiting COX-2 and iNOS gene expression, but elements capable of inhibiting COX-2 and iNOS gene expression also contribute to inhibition of TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	278-281	cytochrome c oxidase II, mitochondrial	Mus musculus	70-75
14573767-6	2003	The activation of T cells by PMA/ionomycin resulted in a marked enhancement of the binding activities to the NF-AT site that was significantly inhibited by the addition of PPAR-gamma ligands.	Tetradecanoylphorbol Acetate	29-32	peroxisome proliferator activated receptor gamma	Mus musculus	172-182
14529724-5	2003	The MEK1/2 inhibitor also suppressed declustering of the ionotropic glutamate receptor subunit 2/3 (GluR2/3) induced by TPA and co-application of high potassium and glutamate, even though phosphorylation of Ser880 of GluR2/3 was not inhibited significantly in the presence of PD98059.	Tetradecanoylphorbol Acetate	120-123	glutamate ionotropic receptor AMPA type subunit 3	Homo sapiens	68-98
14529724-5	2003	The MEK1/2 inhibitor also suppressed declustering of the ionotropic glutamate receptor subunit 2/3 (GluR2/3) induced by TPA and co-application of high potassium and glutamate, even though phosphorylation of Ser880 of GluR2/3 was not inhibited significantly in the presence of PD98059.	Tetradecanoylphorbol Acetate	120-123	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	100-107
14529724-5	2003	The MEK1/2 inhibitor also suppressed declustering of the ionotropic glutamate receptor subunit 2/3 (GluR2/3) induced by TPA and co-application of high potassium and glutamate, even though phosphorylation of Ser880 of GluR2/3 was not inhibited significantly in the presence of PD98059.	Tetradecanoylphorbol Acetate	120-123	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	217-224
14529724-6	2003	These results suggest that ERK1/2 plays an essential role in TPA-induced depression via regulation of GluR2/3 declustering at the synapse.	Tetradecanoylphorbol Acetate	61-64	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	102-107
12874194-8	2003	Both high Pi and phorbol myristate acetate increased the phosphorylation of the NAD(P)H oxidase subunit p47phox.	Tetradecanoylphorbol Acetate	17-42	neutrophil cytosolic factor 1	Rattus norvegicus	104-111
15557817-6	2004	Phorbol 12-myristate 13-acetate (PMA), which is known to activate PKC, stimulated PLD activity significantly more in the core protein-transformed cells, in comparison with that of the control cells.	Tetradecanoylphorbol Acetate	33-36	protein kinase C delta	Homo sapiens	66-69
12791692-3	2003	In addition, using a specific antibody directed to the extracellular N-terminal domain of the 5-HT3A receptor, treatment with the PKC activator, 4 beta-phorbol 12-myristate 13-acetate (PMA), significantly increased surface immunofluorescence.	Tetradecanoylphorbol Acetate	147-183	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	94-100
12791692-6	2003	PMA potentiation is unlikely to occur via direct phosphorylation of the 5-HT3A receptor protein since the potentiation was not affected by point mutation of each of the putative sites for PKC phosphorylation.	Tetradecanoylphorbol Acetate	0-3	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	72-78
15557817-7	2004	PLD activity assay using PKC isozyme-specific inhibitor and PKC translocation experiment showed that PKC-delta was mainly involved in the PMA- induced PLD activation in the core-transformed cells.	Tetradecanoylphorbol Acetate	138-141	protein kinase C delta	Homo sapiens	25-28
12791692-7	2003	However, preapplication of phalloidin, which stabilizes the actin polymerization, significantly inhibited PMA potentiation of 5-HT-activated responses in both N1E-115 cells and oocytes expressing 5-HT3A receptors.	Tetradecanoylphorbol Acetate	106-109	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	196-202
12904296-4	2003	In contrast, syndecan-1 shedding induced by 12-O-tetradecanoylphorbol-13-acetate treatment was inhibited by BB-94 but not by either TIMP-1 or TIMP-2.	Tetradecanoylphorbol Acetate	44-80	syndecan 1	Homo sapiens	13-23
12791692-8	2003	On the other hand, latrunculin-A, which destabilizes actin cytoskeleton, enhanced the PMA potentiation of 5-HT3A receptors.	Tetradecanoylphorbol Acetate	86-89	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	106-112
15557817-7	2004	PLD activity assay using PKC isozyme-specific inhibitor and PKC translocation experiment showed that PKC-delta was mainly involved in the PMA- induced PLD activation in the core-transformed cells.	Tetradecanoylphorbol Acetate	138-141	protein kinase C delta	Homo sapiens	60-63
15557817-7	2004	PLD activity assay using PKC isozyme-specific inhibitor and PKC translocation experiment showed that PKC-delta was mainly involved in the PMA- induced PLD activation in the core-transformed cells.	Tetradecanoylphorbol Acetate	138-141	protein kinase C delta	Homo sapiens	101-110
15492267-3	2004	This negative regulation was established by showing that the PMA-induced macrophage phenotype, but not PMA-associated replication arrest, was abrogated (a) by replenishing the PMA-evoked decrease in cellular spermine levels with this polyamine from an exogenous source and (b) by blocking PMA-induced expression of the polyamine catabolic enzyme N(1)-spermidine/spermine acetyltransferase (SSAT) with antisense oligonucleotides in the presence of low substrate level.	Tetradecanoylphorbol Acetate	61-64	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	346-388
12898704-5	2003	Although PMA increased phosphorylation in all three major MAP kinase pathways (ERK, p38 MAP kinase, and JNK), only inhibition of the ERK pathway by the MEK/ERK inhibitor U0126 (0.1-10 microM) significantly reduced MMP-9 upregulation, even when treatment was delayed for 4 h after PMA exposure.	Tetradecanoylphorbol Acetate	9-12	mitogen activated protein kinase 14	Rattus norvegicus	84-87
14523239-5	2003	We then tested the ability of the PKC-activating phorbol 12-myristate 13-acetate (PMA) to potentiate capsaicin-induced currents and to directly gate TRPV1.	Tetradecanoylphorbol Acetate	49-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	149-154
14523239-5	2003	We then tested the ability of the PKC-activating phorbol 12-myristate 13-acetate (PMA) to potentiate capsaicin-induced currents and to directly gate TRPV1.	Tetradecanoylphorbol Acetate	82-85	transient receptor potential cation channel subfamily V member 1	Homo sapiens	149-154
12890670-8	2003	Furthermore, activation of PKC alpha by phorbol 12-myristate 13-acetate inhibited the activity of wild-type DGK zeta, but not DGK zeta S/D, in human embryonic kidney 293 cells.	Tetradecanoylphorbol Acetate	40-71	diacylglycerol kinase zeta	Homo sapiens	108-116
12865435-7	2003	Interestingly, we further found that caspases-8 and -10 are the initiator caspases in PMA-induced apoptosis and a ROCK-dependent enhancement of specific complex formation between the Fas-associated death domain (FADD) and pro-caspase-10 in pro-apoptotic cells.	Tetradecanoylphorbol Acetate	86-89	caspase 8	Homo sapiens	37-55
12865435-7	2003	Interestingly, we further found that caspases-8 and -10 are the initiator caspases in PMA-induced apoptosis and a ROCK-dependent enhancement of specific complex formation between the Fas-associated death domain (FADD) and pro-caspase-10 in pro-apoptotic cells.	Tetradecanoylphorbol Acetate	86-89	caspase 8	Homo sapiens	37-45
15492267-3	2004	This negative regulation was established by showing that the PMA-induced macrophage phenotype, but not PMA-associated replication arrest, was abrogated (a) by replenishing the PMA-evoked decrease in cellular spermine levels with this polyamine from an exogenous source and (b) by blocking PMA-induced expression of the polyamine catabolic enzyme N(1)-spermidine/spermine acetyltransferase (SSAT) with antisense oligonucleotides in the presence of low substrate level.	Tetradecanoylphorbol Acetate	61-64	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	390-394
15492267-4	2004	The PMA-evoked reduction in cellular spermine appears to result from an increase in the activity of SSAT and a decrease in the activity of ornithine decarboxylase, the polyamine biosynthetic enzyme.	Tetradecanoylphorbol Acetate	4-7	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	100-104
12865435-8	2003	In summary, these results revealed that, following PMA treatment, the upregulation of the RhoA/ROCK pathway contributes to a cellular context that switches-on myosin-mediated contraction, which provides a mechanism for triggering apoptotic induction mediated by caspase-8 and -10.	Tetradecanoylphorbol Acetate	51-54	caspase 8	Homo sapiens	262-279
12807903-1	2003	The ErbB-4 receptor protein-tyrosine kinase is proteolytically processed by membrane proteases in response to the ligand or 12-O-tetradecanoylphorbol-13-acetate stimulation resulting in the cytoplasmic fragment translocating to the cell nucleus.	Tetradecanoylphorbol Acetate	124-160	erb-b2 receptor tyrosine kinase 4	Homo sapiens	4-10
14520467-0	2003	Involvement of nucleophosmin/B23 in TPA-induced megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	36-39	nucleophosmin 1	Homo sapiens	15-28
14520467-0	2003	Involvement of nucleophosmin/B23 in TPA-induced megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	36-39	nucleophosmin 1	Homo sapiens	29-32
14520467-2	2003	The steady-state level of nucleophosmin/B23 mRNA decreased during the TPA-induced differentiation.	Tetradecanoylphorbol Acetate	70-73	nucleophosmin 1	Homo sapiens	26-39
14520467-2	2003	The steady-state level of nucleophosmin/B23 mRNA decreased during the TPA-induced differentiation.	Tetradecanoylphorbol Acetate	70-73	nucleophosmin 1	Homo sapiens	40-43
14520467-3	2003	There was also decrease in the level of cellular nucleophosmin/B23 protein and appearance of its degraded product (25 kDa) during the TPA-induced differentiation.	Tetradecanoylphorbol Acetate	134-137	nucleophosmin 1	Homo sapiens	49-62
14520467-3	2003	There was also decrease in the level of cellular nucleophosmin/B23 protein and appearance of its degraded product (25 kDa) during the TPA-induced differentiation.	Tetradecanoylphorbol Acetate	134-137	nucleophosmin 1	Homo sapiens	63-66
14520467-7	2003	Our results indicate that nucleophosmin/B23 plays an important role in TPA-induced differentiation of K562 cells and the amino acids 244-294 at C-terminal of nucleophosmin/B23 could be an important site for regulation of cellular response to differentiation.	Tetradecanoylphorbol Acetate	71-74	nucleophosmin 1	Homo sapiens	26-39
14520467-7	2003	Our results indicate that nucleophosmin/B23 plays an important role in TPA-induced differentiation of K562 cells and the amino acids 244-294 at C-terminal of nucleophosmin/B23 could be an important site for regulation of cellular response to differentiation.	Tetradecanoylphorbol Acetate	71-74	nucleophosmin 1	Homo sapiens	40-43
12807917-7	2003	Furthermore, Kv1.3 stimulation by Fas ligand was prevented by chronic stimulation of protein kinase C with 20 nm phorbol 12-myristate 13-acetate during Fas ligand treatment, which also blocks apoptosis.	Tetradecanoylphorbol Acetate	113-144	potassium voltage-gated channel subfamily A member 3	Homo sapiens	13-18
14520467-7	2003	Our results indicate that nucleophosmin/B23 plays an important role in TPA-induced differentiation of K562 cells and the amino acids 244-294 at C-terminal of nucleophosmin/B23 could be an important site for regulation of cellular response to differentiation.	Tetradecanoylphorbol Acetate	71-74	nucleophosmin 1	Homo sapiens	172-175
12881422-3	2003	However, the phorbol ester (TPA) and EGF-induced phosphorylation of Ser63 and Ser73 is mediated by ERK1/ERK2, as well as JNK1/JNK2, in fibroblasts from wild-type mice and by ERK1/ERK2 alone in fibroblasts from JNK-deficient mice.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 3	Mus musculus	99-103
15492267-4	2004	The PMA-evoked reduction in cellular spermine appears to result from an increase in the activity of SSAT and a decrease in the activity of ornithine decarboxylase, the polyamine biosynthetic enzyme.	Tetradecanoylphorbol Acetate	4-7	ornithine decarboxylase 1	Homo sapiens	139-162
12881422-3	2003	However, the phorbol ester (TPA) and EGF-induced phosphorylation of Ser63 and Ser73 is mediated by ERK1/ERK2, as well as JNK1/JNK2, in fibroblasts from wild-type mice and by ERK1/ERK2 alone in fibroblasts from JNK-deficient mice.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 3	Mus musculus	174-178
15450404-4	2004	Cytotoxicity, TPA-induced ornithine decarboxylase (ODC) and quinone reductase (QR) activities were evaluated in vitro using HepG2 cells.	Tetradecanoylphorbol Acetate	14-17	ornithine decarboxylase 1	Homo sapiens	26-49
12730223-6	2003	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate stimulated PYK2 phosphorylation and MMP-13 production.	Tetradecanoylphorbol Acetate	37-68	protein kinase C delta	Homo sapiens	22-25
12869563-7	2003	When the m80 ErbB-4 fragment is generated by cell treatment with heregulin or 12-O-tetradecanoylphorbol-13-acetate, the fragment associates with intact ErbB-2.	Tetradecanoylphorbol Acetate	78-114	erb-b2 receptor tyrosine kinase 4	Homo sapiens	13-19
14559850-0	2003	Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.	Tetradecanoylphorbol Acetate	37-73	protein kinase C, epsilon	Mus musculus	0-23
14559850-0	2003	Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.	Tetradecanoylphorbol Acetate	37-73	protein kinase C, epsilon	Mus musculus	191-214
15450404-4	2004	Cytotoxicity, TPA-induced ornithine decarboxylase (ODC) and quinone reductase (QR) activities were evaluated in vitro using HepG2 cells.	Tetradecanoylphorbol Acetate	14-17	ornithine decarboxylase 1	Homo sapiens	51-54
14519120-0	2003	PKCdelta-dependent cleavage and nuclear translocation of annexin A1 by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	71-102	protein kinase C delta	Homo sapiens	0-8
15450404-8	2004	The greatest inhibition (82%) of TPA-induced ODC activity was shown by Q, with 25 microM (IC50 = 11.90 microM).	Tetradecanoylphorbol Acetate	33-36	ornithine decarboxylase 1	Homo sapiens	45-48
14519120-6	2003	The PMA-induced nuclear translocation of ANX-1 was inhibited by the protein kinase C (PKC)delta-specific inhibitor rottlerin, indicating that PKCdelta plays a role in nuclear translocation of the cleaved ANX-1.	Tetradecanoylphorbol Acetate	4-7	protein kinase C delta	Homo sapiens	142-150
12960243-7	2003	The serine protease inhibitor phenylmethylsulfonyl fluoride (PMSF) augmented membrane expression of PR3 in unactivated and PMA-stimulated neutrophils.	Tetradecanoylphorbol Acetate	123-126	proteinase 3	Homo sapiens	100-103
12829841-10	2003	In tetradecanoyl phorbol acetate-treated PEL cells, loss of LANA expression correlated temporally with loss of detectable beta-catenin.	Tetradecanoylphorbol Acetate	3-32	LANA	Human gammaherpesvirus 8	60-64
15342368-3	2004	The dorsal skin of NQO2-deficient mice was exposed to 7,12-dimethylbenz(a)anthracene (DMBA) or benzo(a)pyrene alone (complete carcinogen) or with 12-O-tetradecanoylphorbol-13-acetate (TPA) (initiation/promotion model) to determine the in vivo role of NQO2 in chemical carcinogenesis.	Tetradecanoylphorbol Acetate	146-182	N-ribosyldihydronicotinamide quinone reductase 2	Mus musculus	19-23
15342368-4	2004	The NQO2-/- mice showed significantly increased tumor frequency with DMBA + TPA when compared with their wild-type littermates.	Tetradecanoylphorbol Acetate	76-79	N-ribosyldihydronicotinamide quinone reductase 2	Mus musculus	4-8
12951045-5	2003	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), which directly stimulates protein kinase C (PKC) activity, completely prevented WISP-2 mRNA induction by E2, whereas it increased pS2 mRNA expression more dramatically than maximum stimulation by E2.	Tetradecanoylphorbol Acetate	15-51	cellular communication network factor 5	Homo sapiens	139-145
12951045-5	2003	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), which directly stimulates protein kinase C (PKC) activity, completely prevented WISP-2 mRNA induction by E2, whereas it increased pS2 mRNA expression more dramatically than maximum stimulation by E2.	Tetradecanoylphorbol Acetate	53-56	cellular communication network factor 5	Homo sapiens	139-145
15314085-6	2004	Moreover, the PKC activator phorbol 12-myristate 13-acetate (PMA) together with bFGF and dbcAMP led to a significant increase in phospho-ERK1/ERK2 levels, and the percentage of beta-tubulin III-positive cells that expressed tyrosine hydroxylase increased by 3.5-fold.	Tetradecanoylphorbol Acetate	28-59	fibroblast growth factor 2	Rattus norvegicus	80-84
12826681-2	2003	Several authors have described how 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of cells results in an increase of Src activity, but the mechanism of the PKC-mediated Src activation is unknown.	Tetradecanoylphorbol Acetate	73-76	protein kinase C, delta	Rattus norvegicus	164-167
12857855-7	2003	Finally, although tPA(-/-) mice are normally resistant to excitotoxin-induced neurodegeneration, disruption of the endogenous laminin layer by laminin-1 or anti-laminin gamma1 antibody renders the tPA(-/-) hippocampal neurons sensitive to kainate.	Tetradecanoylphorbol Acetate	197-200	laminin, gamma 1	Mus musculus	161-175
15314085-6	2004	Moreover, the PKC activator phorbol 12-myristate 13-acetate (PMA) together with bFGF and dbcAMP led to a significant increase in phospho-ERK1/ERK2 levels, and the percentage of beta-tubulin III-positive cells that expressed tyrosine hydroxylase increased by 3.5-fold.	Tetradecanoylphorbol Acetate	28-59	mitogen activated protein kinase 3	Rattus norvegicus	137-141
12844482-4	2003	In the present work, we assessed the effects of curcumin on 12-O- tetradecanoylphorbol-13-acetate (TPA)-induced expression of cyclooxygenase-2 (COX-2) in female ICR mouse skin.	Tetradecanoylphorbol Acetate	60-97	prostaglandin-endoperoxide synthase 2	Mus musculus	126-142
12844482-4	2003	In the present work, we assessed the effects of curcumin on 12-O- tetradecanoylphorbol-13-acetate (TPA)-induced expression of cyclooxygenase-2 (COX-2) in female ICR mouse skin.	Tetradecanoylphorbol Acetate	60-97	prostaglandin-endoperoxide synthase 2	Mus musculus	144-149
15314085-6	2004	Moreover, the PKC activator phorbol 12-myristate 13-acetate (PMA) together with bFGF and dbcAMP led to a significant increase in phospho-ERK1/ERK2 levels, and the percentage of beta-tubulin III-positive cells that expressed tyrosine hydroxylase increased by 3.5-fold.	Tetradecanoylphorbol Acetate	28-59	mitogen activated protein kinase 1	Rattus norvegicus	142-146
12844482-4	2003	In the present work, we assessed the effects of curcumin on 12-O- tetradecanoylphorbol-13-acetate (TPA)-induced expression of cyclooxygenase-2 (COX-2) in female ICR mouse skin.	Tetradecanoylphorbol Acetate	99-102	prostaglandin-endoperoxide synthase 2	Mus musculus	126-142
12844482-4	2003	In the present work, we assessed the effects of curcumin on 12-O- tetradecanoylphorbol-13-acetate (TPA)-induced expression of cyclooxygenase-2 (COX-2) in female ICR mouse skin.	Tetradecanoylphorbol Acetate	99-102	prostaglandin-endoperoxide synthase 2	Mus musculus	144-149
12767686-7	2003	Furthermore, PGF(2alpha) (but not PGE(2)) clearly reduced the inhibition of TPA-induced promotion by NS-398, an isozyme-specific inhibitor of cyclooxygenase-2.	Tetradecanoylphorbol Acetate	76-79	prostaglandin-endoperoxide synthase 2	Mus musculus	142-158
15314085-6	2004	Moreover, the PKC activator phorbol 12-myristate 13-acetate (PMA) together with bFGF and dbcAMP led to a significant increase in phospho-ERK1/ERK2 levels, and the percentage of beta-tubulin III-positive cells that expressed tyrosine hydroxylase increased by 3.5-fold.	Tetradecanoylphorbol Acetate	61-64	fibroblast growth factor 2	Rattus norvegicus	80-84
12844482-5	2003	Topical application of the dorsal skin of female ICR mice with 10 nmol TPA led to maximal induction of cox-2 mRNA and protein expression at approximately 1 and 4 h, respectively.	Tetradecanoylphorbol Acetate	71-74	prostaglandin-endoperoxide synthase 2	Mus musculus	103-108
12844482-7	2003	Immunohistochemical analysis of TPA-treated mouse skin revealed enhanced expression of COX-2 localized primarily in epidermal layer, which was markedly suppressed by curcumin pre-treatment.	Tetradecanoylphorbol Acetate	32-35	prostaglandin-endoperoxide synthase 2	Mus musculus	87-92
15314085-6	2004	Moreover, the PKC activator phorbol 12-myristate 13-acetate (PMA) together with bFGF and dbcAMP led to a significant increase in phospho-ERK1/ERK2 levels, and the percentage of beta-tubulin III-positive cells that expressed tyrosine hydroxylase increased by 3.5-fold.	Tetradecanoylphorbol Acetate	61-64	mitogen activated protein kinase 3	Rattus norvegicus	137-141
12844482-9	2003	TPA treatment resulted in rapid activation via phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and p38 mitogen-activated protein (MAP) kinases, which are upstream of NF-kappaB.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Mus musculus	66-112
12810623-1	2003	The role of 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated polyamine biosynthesis in the development of metastatic squamous cell carcinoma (mSCC) in protein kinase C epsilon (PKC epsilon) transgenic mice was determined.	Tetradecanoylphorbol Acetate	12-48	protein kinase C, epsilon	Mus musculus	156-180
12844482-9	2003	TPA treatment resulted in rapid activation via phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and p38 mitogen-activated protein (MAP) kinases, which are upstream of NF-kappaB.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 14	Mus musculus	117-120
15314085-6	2004	Moreover, the PKC activator phorbol 12-myristate 13-acetate (PMA) together with bFGF and dbcAMP led to a significant increase in phospho-ERK1/ERK2 levels, and the percentage of beta-tubulin III-positive cells that expressed tyrosine hydroxylase increased by 3.5-fold.	Tetradecanoylphorbol Acetate	61-64	mitogen activated protein kinase 1	Rattus norvegicus	142-146
12810623-1	2003	The role of 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated polyamine biosynthesis in the development of metastatic squamous cell carcinoma (mSCC) in protein kinase C epsilon (PKC epsilon) transgenic mice was determined.	Tetradecanoylphorbol Acetate	50-53	protein kinase C, epsilon	Mus musculus	156-180
12810623-1	2003	The role of 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated polyamine biosynthesis in the development of metastatic squamous cell carcinoma (mSCC) in protein kinase C epsilon (PKC epsilon) transgenic mice was determined.	Tetradecanoylphorbol Acetate	50-53	protein kinase C, epsilon	Mus musculus	182-193
15314085-7	2004	PMA also promoted the phosphorylation of the cyclic AMP response element binding protein that might contribute to the increase in tyrosine hydroxylase-positive cells observed in bFGF+dbcAMP+PMA-treated cultures.	Tetradecanoylphorbol Acetate	0-3	fibroblast growth factor 2	Rattus norvegicus	178-182
12810623-2	2003	TPA treatment induced epidermal ornithine decarboxylase (ODC) activity and putrescine levels approximately 3-4-fold more in PKC epsilon transgenic mice than their wild-type littermates.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, epsilon	Mus musculus	124-135
12810623-6	2003	These results indicate that TPA-induced ODC activity and the resultant accumulation of putrescine in PKC epsilon transgenic mice are linked to growth and maintenance of hair follicles, and the development of mSCC.	Tetradecanoylphorbol Acetate	28-31	protein kinase C, epsilon	Mus musculus	101-112
12915572-6	2003	Furthermore, chromatin immunoprecipitation assay results showed that the endogenous C/EBPalpha, RTA, and RAP proteins all associate with RTA promoter sequences in tetradecanoyl phorbol acetate-induced primary effusion lymphoma (PEL) cells.	Tetradecanoylphorbol Acetate	163-192	RNA binding fox-1 homolog 2	Homo sapiens	96-99
12915572-6	2003	Furthermore, chromatin immunoprecipitation assay results showed that the endogenous C/EBPalpha, RTA, and RAP proteins all associate with RTA promoter sequences in tetradecanoyl phorbol acetate-induced primary effusion lymphoma (PEL) cells.	Tetradecanoylphorbol Acetate	163-192	RNA binding fox-1 homolog 2	Homo sapiens	137-140
15460057-0	2004	[Expression of nerve growth factor mRNA and nerve regeneration after discontinuous injection of phorbol-12-myristate-13-acetate into silicone chamber].	Tetradecanoylphorbol Acetate	96-127	nerve growth factor	Rattus norvegicus	15-34
15358156-3	2004	Here we report that phorbol 12-myristate 13-acetate (PMA) up-regulates cPLA(2)alpha in A549 airway epithelium cells, and that this effect is sensitive to rottlerin, a potent inhibitor of protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	20-51	protein kinase C delta	Homo sapiens	187-208
12871219-2	2003	Both peripheral blood mononuclear cells (PBMC) and primary human T cells display similar patterns of IL-5 expression when stimulated with both phorbol-12-myristate 13-acetate and phytohaemagglutinin.	Tetradecanoylphorbol Acetate	143-174	interleukin 5	Homo sapiens	101-105
15358156-3	2004	Here we report that phorbol 12-myristate 13-acetate (PMA) up-regulates cPLA(2)alpha in A549 airway epithelium cells, and that this effect is sensitive to rottlerin, a potent inhibitor of protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	20-51	protein kinase C delta	Homo sapiens	210-218
12851698-0	2003	NAMI-A inhibits the PMA-induced ODC gene expression in ECV304 cells: involvement of PKC/Raf/Mek/ERK signalling pathway.	Tetradecanoylphorbol Acetate	20-23	ornithine decarboxylase 1	Homo sapiens	32-35
12851698-0	2003	NAMI-A inhibits the PMA-induced ODC gene expression in ECV304 cells: involvement of PKC/Raf/Mek/ERK signalling pathway.	Tetradecanoylphorbol Acetate	20-23	zinc fingers and homeoboxes 2	Homo sapiens	88-91
12682854-7	2003	Further analyses disclosed that the 12- o-tetradecanoylphorbol-13-acetate (TPA)-responsive element (TRE), T2 (-272 to -278), in cystatin A promoter is critical for the regulation by 1,25(OH)(2)D3.	Tetradecanoylphorbol Acetate	36-73	cystatin A	Homo sapiens	128-138
12682854-7	2003	Further analyses disclosed that the 12- o-tetradecanoylphorbol-13-acetate (TPA)-responsive element (TRE), T2 (-272 to -278), in cystatin A promoter is critical for the regulation by 1,25(OH)(2)D3.	Tetradecanoylphorbol Acetate	75-78	cystatin A	Homo sapiens	128-138
15358156-3	2004	Here we report that phorbol 12-myristate 13-acetate (PMA) up-regulates cPLA(2)alpha in A549 airway epithelium cells, and that this effect is sensitive to rottlerin, a potent inhibitor of protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	53-56	protein kinase C delta	Homo sapiens	187-208
15358156-3	2004	Here we report that phorbol 12-myristate 13-acetate (PMA) up-regulates cPLA(2)alpha in A549 airway epithelium cells, and that this effect is sensitive to rottlerin, a potent inhibitor of protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	53-56	protein kinase C delta	Homo sapiens	210-218
12761575-2	2003	12-O-tetradecanoylphorbol-13-acetate induces apoptosis in SK-N-BE(2) neuroblastoma cells overexpressing PKCdelta or PKCtheta, but not PKC epsilon.	Tetradecanoylphorbol Acetate	0-36	protein kinase C delta	Homo sapiens	104-112
12829741-6	2003	Additionally, the protein kinase C (PKC) delta-selective blocker, rottlerin, inhibited PMA-stimulated depolarization, indicating that PKCdelta was involved in regulating depolarization associated with eosinophil NADPH oxidase activity.	Tetradecanoylphorbol Acetate	87-90	protein kinase C delta	Homo sapiens	36-39
15245430-6	2004	Treatment with PPAR-gamma activators also reduced the cutaneous inflammatory response that is induced by phorbol 12-myristate-13-acetate, a model of irritant contact dermatitis and oxazolone, a model of allergic contact dermatitis.	Tetradecanoylphorbol Acetate	105-136	peroxisome proliferator activated receptor gamma	Mus musculus	15-25
12829741-6	2003	Additionally, the protein kinase C (PKC) delta-selective blocker, rottlerin, inhibited PMA-stimulated depolarization, indicating that PKCdelta was involved in regulating depolarization associated with eosinophil NADPH oxidase activity.	Tetradecanoylphorbol Acetate	87-90	protein kinase C delta	Homo sapiens	134-142
12734388-3	2003	Direct activation of PKC by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA) or 1,2-dioctanoyl-sn-glycerol (DOG) desensitized CRF1 receptors in Y79 cells, reducing the maximum for CRF- (but not forskolin)-stimulated cAMP accumulation by 56.3 +/- 1.2% and 40.4 +/- 2.1%, respectively (p &lt; 0.001).	Tetradecanoylphorbol Acetate	61-92	corticotropin releasing hormone receptor 1	Homo sapiens	148-152
12734388-3	2003	Direct activation of PKC by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA) or 1,2-dioctanoyl-sn-glycerol (DOG) desensitized CRF1 receptors in Y79 cells, reducing the maximum for CRF- (but not forskolin)-stimulated cAMP accumulation by 56.3 +/- 1.2% and 40.4 +/- 2.1%, respectively (p &lt; 0.001).	Tetradecanoylphorbol Acetate	94-97	corticotropin releasing hormone receptor 1	Homo sapiens	148-152
12734388-6	2003	When alpha and beta isoforms of PKC were down-regulated 80 to 90% by a 48-h PMA exposure, PMA-induced CRF1 receptor desensitization was abolished.	Tetradecanoylphorbol Acetate	76-79	corticotropin releasing hormone receptor 1	Homo sapiens	102-106
12755693-7	2003	By examination of furin reconstituted LoVo cells we were able to exclude the possibility that PMA modulates furin activity.	Tetradecanoylphorbol Acetate	94-97	furin, paired basic amino acid cleaving enzyme	Homo sapiens	108-113
12755693-8	2003	Moreover, the PMA dependent decrease of the mature enzyme form is specific for TACE, as the amount of mature ADAM10 was unaffected in PMA-treated HEK293 and SH-SY5Y cells.	Tetradecanoylphorbol Acetate	14-17	ADAM metallopeptidase domain 10	Homo sapiens	109-115
15138267-2	2004	The signal link between the BCR and CREB activation depends on a phorbol ester (phorbol 12-myristate 13-acetate)-sensitive protein kinase C (PKC) activity and not protein kinase A or calmodulin kinase; however, the identity and role of the PKC(s) activity has not been elucidated.	Tetradecanoylphorbol Acetate	80-111	protein kinase C delta	Homo sapiens	141-144
12881712-5	2003	The expression of the death adapter FADD and caspase-8 was required for Fas-induced FOXO3a cleavage, but activation of survival pathways by overexpression of FLICE-inhibitory protein or phorbol myristate acetate treatment prevented it.	Tetradecanoylphorbol Acetate	186-211	caspase 8	Homo sapiens	45-54
15117942-6	2004	Furthermore, we found that treatment with both ionomycin and phorbol 12-myristate 13-acetate ensured efficient nuclear anchorage with the recruitment of NFAT1 into the SUMO-1 bodies, whereas treatment with ionomycin alone induced nuclear translocation of NFAT1 but not recruitment into the SUMO-1 bodies.	Tetradecanoylphorbol Acetate	61-92	small ubiquitin like modifier 1	Homo sapiens	168-174
12788080-10	2003	PMA pretreatment to deplete PKC inhibited PMA-induced, but not PTH-induced, NOR-1 mRNA.	Tetradecanoylphorbol Acetate	0-3	nuclear receptor subfamily 4, group A, member 3	Mus musculus	76-81
12697837-1	2003	Phorbol esters such as 12-O-tetradeconylphorbol-13-acetate (TPA) activate protein kinase C, increase Connexin43 (Cx43) phosphorylation, and decrease cell-cell communication via gap junctions in many cell types.	Tetradecanoylphorbol Acetate	60-63	gap junction protein alpha 1	Homo sapiens	101-111
12697837-1	2003	Phorbol esters such as 12-O-tetradeconylphorbol-13-acetate (TPA) activate protein kinase C, increase Connexin43 (Cx43) phosphorylation, and decrease cell-cell communication via gap junctions in many cell types.	Tetradecanoylphorbol Acetate	60-63	gap junction protein alpha 1	Homo sapiens	113-117
12697837-4	2003	We show that this antibody detects Cx43 only when it is phosphorylated at S368 and, consistent with previous results, TPA treatment causes a dramatic increase in phosphorylation at S368.	Tetradecanoylphorbol Acetate	118-121	gap junction protein alpha 1	Homo sapiens	35-39
12734401-2	2003	In this report, we investigated the mechanisms by which phorbol myristate acetate (PMA) promotes LFA-1-dependent cell adhesion.	Tetradecanoylphorbol Acetate	56-81	integrin subunit alpha L	Homo sapiens	97-102
12734401-2	2003	In this report, we investigated the mechanisms by which phorbol myristate acetate (PMA) promotes LFA-1-dependent cell adhesion.	Tetradecanoylphorbol Acetate	83-86	integrin subunit alpha L	Homo sapiens	97-102
15117942-6	2004	Furthermore, we found that treatment with both ionomycin and phorbol 12-myristate 13-acetate ensured efficient nuclear anchorage with the recruitment of NFAT1 into the SUMO-1 bodies, whereas treatment with ionomycin alone induced nuclear translocation of NFAT1 but not recruitment into the SUMO-1 bodies.	Tetradecanoylphorbol Acetate	61-92	small ubiquitin like modifier 1	Homo sapiens	290-296
15117942-7	2004	Our results suggest that the recruitment of NFAT1 into SUMO-1 bodies may be required for the progressive transcriptional activity of NFAT1 upon co-stimulation with ionomycin and phorbol 12-myristate 13-acetate, whereas anergic transcription stimulated by ionomycin alone may occur without recruitment into the SUMO-1 bodies.	Tetradecanoylphorbol Acetate	178-209	small ubiquitin like modifier 1	Homo sapiens	55-61
15028631-4	2004	Cells were incubated on semipermeable membranes in 20% or 2% O(2) with or without the tumor promoter phorbol 12-myristate 13-acetate, which activates matrix metalloproteinase-2 and -9 in endothelial cells.	Tetradecanoylphorbol Acetate	101-132	matrix metallopeptidase 2	Homo sapiens	150-183
12745250-5	2003	Further indication that oxidation regulates Grx-1 expression was noted by the positive effect of phorbol 12-myristate 13-acetate, a known inducer of redox-sensitive AP-1 transcription factor.	Tetradecanoylphorbol Acetate	97-128	glutaredoxin	Homo sapiens	44-49
12787062-5	2003	TH gene transcription rate increased from four- to eight-fold in control cells after treatment with either 50 mM KCl or TPA.	Tetradecanoylphorbol Acetate	120-123	tyrosine hydroxylase	Rattus norvegicus	0-2
12787062-8	2003	Stimulation of TH gene promoter activity, which was observed in control cell lines treated with either 50 mm KCl or TPA was also dramatically inhibited in the c-Fos-deficient cells.	Tetradecanoylphorbol Acetate	116-119	tyrosine hydroxylase	Rattus norvegicus	15-17
12646569-4	2003	Protein kinase activators (cAMP, forskolin, or phorbol-12-myristate-13-acetate) markedly increased GSTA4-4 targeting to mitochondria, whereas kinase inhibitors caused its retention in the cytosol.	Tetradecanoylphorbol Acetate	47-78	glutathione S-transferase, alpha 4	Mus musculus	99-106
15499968-8	2004	TNFalpha mRNA expression was increased after 15 min exposure to FB1 or the PKC activator, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	90-121	tumor necrosis factor	Sus scrofa	0-8
12522006-1	2003	Monocytic differentiation of 32DPKCdelta cells in response to activation of protein kinase C delta (PKCdelta) by phorbol 12-myristate 13-acetate (PMA) was inhibited by exogenous CCAAT/enhancer binding protein alpha-estradiol receptor (C/EBPalpha-ER), which impeded morphologic maturation and induction of macrosialin mRNA.	Tetradecanoylphorbol Acetate	113-144	protein kinase C delta	Homo sapiens	76-98
12522006-1	2003	Monocytic differentiation of 32DPKCdelta cells in response to activation of protein kinase C delta (PKCdelta) by phorbol 12-myristate 13-acetate (PMA) was inhibited by exogenous CCAAT/enhancer binding protein alpha-estradiol receptor (C/EBPalpha-ER), which impeded morphologic maturation and induction of macrosialin mRNA.	Tetradecanoylphorbol Acetate	113-144	protein kinase C delta	Homo sapiens	32-40
12522006-1	2003	Monocytic differentiation of 32DPKCdelta cells in response to activation of protein kinase C delta (PKCdelta) by phorbol 12-myristate 13-acetate (PMA) was inhibited by exogenous CCAAT/enhancer binding protein alpha-estradiol receptor (C/EBPalpha-ER), which impeded morphologic maturation and induction of macrosialin mRNA.	Tetradecanoylphorbol Acetate	146-149	protein kinase C delta	Homo sapiens	76-98
12790799-10	2003	Thus, FFA/PMA-induced activation of novel PKC isoforms can inhibit glucose/IGF-I-mediated beta-cell mitogenesis, in part by decreasing PKB activation, despite an upregulation of Erk1/2.	Tetradecanoylphorbol Acetate	10-13	mitogen activated protein kinase 3	Rattus norvegicus	178-184
15242943-8	2004	As already described for more conventional techniques, we showed that certain genes, such as those for CD40, gamma interferon, interleukin 2 (IL-2), the IL-2 receptor, and tumor necrosis factor alpha, were upregulated in PMA-Iono-stimulated PBMCs.	Tetradecanoylphorbol Acetate	221-224	tumor necrosis factor	Sus scrofa	153-199
12745093-2	2003	We found that phorbol-12-myristate-13-acetate (PMA)-stimulated invasion of the hepatocellular carcinoma (HCC) SNU-387 and SNU-398 cells and that PMA induced the secretion of MMP-9 in the cells, but did not induce the secretion of MMP-2.	Tetradecanoylphorbol Acetate	14-45	matrix metallopeptidase 2	Homo sapiens	230-235
15122579-6	2004	Further, it diminished TPA-induced cyclooxygenase-2 protein expression and phosphorylation of extracellular signal-regulated kinase 1/2, while pretreatment(s), in either the priming or activation stage or both, reduced double TPA application-induced hydrogen peroxide formation and edema induction by 29% to 86%, respectively.	Tetradecanoylphorbol Acetate	23-26	prostaglandin-endoperoxide synthase 2	Mus musculus	35-51
12745093-2	2003	We found that phorbol-12-myristate-13-acetate (PMA)-stimulated invasion of the hepatocellular carcinoma (HCC) SNU-387 and SNU-398 cells and that PMA induced the secretion of MMP-9 in the cells, but did not induce the secretion of MMP-2.	Tetradecanoylphorbol Acetate	47-50	matrix metallopeptidase 2	Homo sapiens	230-235
12730016-0	2003	Atypical mechanisms regulate the PMA-induced expression of IFN-gamma in a porcine trophectoderm cell line.	Tetradecanoylphorbol Acetate	33-36	interferon gamma	Sus scrofa	59-68
12730016-5	2003	We found that treatment of polarized TBA B4-3 cells with the strong PKC agonist PMA induced, 3-4 days later, a transient IFN-gamma mRNA expression and vectorial IFN-gamma protein secretion.	Tetradecanoylphorbol Acetate	80-83	interferon gamma	Sus scrofa	121-130
12730016-5	2003	We found that treatment of polarized TBA B4-3 cells with the strong PKC agonist PMA induced, 3-4 days later, a transient IFN-gamma mRNA expression and vectorial IFN-gamma protein secretion.	Tetradecanoylphorbol Acetate	80-83	interferon gamma	Sus scrofa	161-170
12730016-8	2003	In addition, we found that although PMA alone can induce IFN-gamma secretion, the calcium ionophore A23187 synergizes with PMA for induction.	Tetradecanoylphorbol Acetate	36-39	interferon gamma	Sus scrofa	57-66
15122579-6	2004	Further, it diminished TPA-induced cyclooxygenase-2 protein expression and phosphorylation of extracellular signal-regulated kinase 1/2, while pretreatment(s), in either the priming or activation stage or both, reduced double TPA application-induced hydrogen peroxide formation and edema induction by 29% to 86%, respectively.	Tetradecanoylphorbol Acetate	23-26	mitogen-activated protein kinase 3	Mus musculus	94-135
12707358-2	2003	A protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or a Src kinase inhibitor (PP2) attenuated TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 promoter activity.	Tetradecanoylphorbol Acetate	166-202	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	136-139
12737946-12	2003	The CD69 protein is induced by TPA in thymocytes and is a type II transmembrane signaling molecule in hematopoietic cells.	Tetradecanoylphorbol Acetate	31-34	CD69 molecule	Homo sapiens	4-8
12707358-2	2003	A protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or a Src kinase inhibitor (PP2) attenuated TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 promoter activity.	Tetradecanoylphorbol Acetate	204-207	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	136-139
12694376-5	2003	Both wound-healing and Boyden migration assays showed that TPA treatment promoted neuronal migration of GT1 cells; however, cotreatment of TPA with safingol or rottlerin (a PKC delta-selective inhibitor) clearly blocked this TPA effect, indicating that both PKC alpha and PKC delta may be positive regulators of neuronal migration.	Tetradecanoylphorbol Acetate	139-142	protein kinase C delta	Homo sapiens	173-182
15232218-4	2004	Interestingly, rottlerin, a selective inhibitor of PKCdelta, reduced PMA-induced RANK expression while having no effect on CD11b expression.	Tetradecanoylphorbol Acetate	69-72	protein kinase C delta	Homo sapiens	51-59
12652654-2	2003	The ability of phorbol myristyl acetate (PMA), a protein kinase C activator that has been reported to increase macrophage spreading and carcinoma cell motility, to rescue these hck(-/-)fgr(-/-) defects was tested.	Tetradecanoylphorbol Acetate	41-44	FGR proto-oncogene, Src family tyrosine kinase	Mus musculus	185-188
12652654-3	2003	Although PMA-treated wild-type and hck(-/-)fgr(-/-) macrophages exhibited a similar flattened, spread phenotype, PMA did not rescue the hck(-/-)fgr(-/-) macrophage migration defect.	Tetradecanoylphorbol Acetate	9-12	FGR proto-oncogene, Src family tyrosine kinase	Mus musculus	43-46
15232218-4	2004	Interestingly, rottlerin, a selective inhibitor of PKCdelta, reduced PMA-induced RANK expression while having no effect on CD11b expression.	Tetradecanoylphorbol Acetate	69-72	TNF receptor superfamily member 11a	Homo sapiens	81-85
15232218-5	2004	However overexpression of wild type PKCdelta, or a kinase-inactive mutant, did not affect PMA-induction of RANK, suggesting that rottlerin inhibits PMA-induced expression of RANK via a PKCdelta-independent mechanism.	Tetradecanoylphorbol Acetate	148-151	TNF receptor superfamily member 11a	Homo sapiens	174-178
12694376-5	2003	Both wound-healing and Boyden migration assays showed that TPA treatment promoted neuronal migration of GT1 cells; however, cotreatment of TPA with safingol or rottlerin (a PKC delta-selective inhibitor) clearly blocked this TPA effect, indicating that both PKC alpha and PKC delta may be positive regulators of neuronal migration.	Tetradecanoylphorbol Acetate	139-142	protein kinase C delta	Homo sapiens	272-281
12694376-7	2003	Among the PKC downstream signal molecules, p130Cas, a mediator of cell migration, and its kinase, focal adhesion kinase (FAK), increased following TPA treatment; phosphorylation of p130Cas was induced in a PKC alpha-dependent manner.	Tetradecanoylphorbol Acetate	147-150	protein tyrosine kinase 2	Homo sapiens	98-119
15232218-6	2004	Rottlerin also inhibited PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38MAPK), and the p38 MAPK inhibitor SB203580 inhibited induction of RANK.	Tetradecanoylphorbol Acetate	25-28	TNF receptor superfamily member 11a	Homo sapiens	163-167
12694376-7	2003	Among the PKC downstream signal molecules, p130Cas, a mediator of cell migration, and its kinase, focal adhesion kinase (FAK), increased following TPA treatment; phosphorylation of p130Cas was induced in a PKC alpha-dependent manner.	Tetradecanoylphorbol Acetate	147-150	protein tyrosine kinase 2	Homo sapiens	121-124
12842447-5	2003	Clodronate also downregulated the PMA-induced expression of MT1-MMP mRNA and protein production in human MG-63 osteosarcoma cells, as evidenced by Northern analysis and fluorescent immunohistochemistry.	Tetradecanoylphorbol Acetate	34-37	matrix metallopeptidase 14	Homo sapiens	60-67
15144907-7	2004	In acute promyelocytic leukemia (APL) HL-60 and NB4 cell lines, Rab7b expression is upregulated after phorbol myristate acetate (PMA)-induced monocytic differentiation.	Tetradecanoylphorbol Acetate	102-127	RAB7B, member RAS oncogene family	Homo sapiens	64-69
12694198-4	2003	In order to examine the function of tetranectin, a kinetic analysis of the tPA-catalysed plasminogen activation was performed.	Tetradecanoylphorbol Acetate	75-78	C-type lectin domain family 3 member B	Homo sapiens	36-47
12647293-3	2003	We observed a PMA-stimulated intact cell phosphorylation of Galpha(15) in COS7 cells transfected with Galpha(15) and protein kinase Calpha (PKCalpha), and phosphorylation of endogenous Galpha(16) in HL60 cells.	Tetradecanoylphorbol Acetate	14-17	G protein subunit alpha 15	Homo sapiens	185-195
15144907-7	2004	In acute promyelocytic leukemia (APL) HL-60 and NB4 cell lines, Rab7b expression is upregulated after phorbol myristate acetate (PMA)-induced monocytic differentiation.	Tetradecanoylphorbol Acetate	129-132	RAB7B, member RAS oncogene family	Homo sapiens	64-69
12694198-5	2003	The kinetic parameters of the tetranectin-stimulated enhancement of tPA were comparable to fibrinogen fragments, which are so far the best inducer of tPA-catalysed plasminogen activation.	Tetradecanoylphorbol Acetate	68-71	C-type lectin domain family 3 member B	Homo sapiens	30-41
12694198-5	2003	The kinetic parameters of the tetranectin-stimulated enhancement of tPA were comparable to fibrinogen fragments, which are so far the best inducer of tPA-catalysed plasminogen activation.	Tetradecanoylphorbol Acetate	150-153	C-type lectin domain family 3 member B	Homo sapiens	30-41
15158761-4	2004	TPA preferentially increased the transcription of cyclooxygenase (COX)-2 in MDCK cells, whereas the expression of LOXs was almost negligible.	Tetradecanoylphorbol Acetate	0-3	cytochrome c oxidase subunit II	Canis lupus familiaris	50-72
12694198-6	2003	The enhanced activation was suggested to be caused by tetranectin"s ability to bind and accumulate tPA in an active conformation.	Tetradecanoylphorbol Acetate	99-102	C-type lectin domain family 3 member B	Homo sapiens	54-65
12702576-2	2003	Microarray analysis revealed overexpression of the Scca2 gene in the 12-O-tetradecanoylphorbol-13-acetate-treated skin of Car-S mice, or line phenotypically selected for high susceptibility to two-stage skin carcinogenesis, as compared with 12-O-tetradecanoylphorbol-13-acetate-treated skin of Car-R mice, which is resistant.	Tetradecanoylphorbol Acetate	69-105	serine (or cysteine) peptidase inhibitor, clade B, member 3C	Mus musculus	51-56
12702576-2	2003	Microarray analysis revealed overexpression of the Scca2 gene in the 12-O-tetradecanoylphorbol-13-acetate-treated skin of Car-S mice, or line phenotypically selected for high susceptibility to two-stage skin carcinogenesis, as compared with 12-O-tetradecanoylphorbol-13-acetate-treated skin of Car-R mice, which is resistant.	Tetradecanoylphorbol Acetate	241-277	serine (or cysteine) peptidase inhibitor, clade B, member 3C	Mus musculus	51-56
15158761-7	2004	Calcium ionophore A23187 was markedly effective to attenuate the TPA-induced apoptosis, indicating that elevated endogenous prostaglandins (PGs) served as survival factors through not only the activation of phospholipase A(2) by A23187 but also the induction of COX-2 by TPA.	Tetradecanoylphorbol Acetate	65-68	cytochrome c oxidase subunit II	Canis lupus familiaris	262-267
12841345-6	2003	LDL and lipoprotein(a) [Lp(a)], another lipoprotein risk factor for CHD, reduced the generation of tPA from EC.	Tetradecanoylphorbol Acetate	99-102	lipoprotein(a)	Homo sapiens	8-22
12841345-6	2003	LDL and lipoprotein(a) [Lp(a)], another lipoprotein risk factor for CHD, reduced the generation of tPA from EC.	Tetradecanoylphorbol Acetate	99-102	lipoprotein(a)	Homo sapiens	24-29
15161746-9	2004	In addition, PMA-induced phosphorylation of JNK and ERK1/2 are preserved, whereas p38 MAPK pathways are impaired in skeletal muscle from ob/ob mice.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 3	Mus musculus	52-58
12766328-2	2003	Using the immortalized GnRH-producing GT1 cell line, we found that activation of protein kinase C (PKC) with 12-O-tetradecanoylphorbol-13-acetate induces morphological and functional differentiation of these neurons.	Tetradecanoylphorbol Acetate	109-145	gonadotropin releasing hormone 1	Homo sapiens	23-27
12670492-7	2003	Phorbol 12-myristate 13-acetate down-regulated the expression of both CYP2D25 and CYP27A1 as well as the 25-hydroxylase activity of the hepatocytes.	Tetradecanoylphorbol Acetate	0-31	cytochrome P450 family 27 subfamily A member 1	Sus scrofa	82-89
12632075-0	2003	Rhein inhibits TPA-induced activator protein-1 activation and cell transformation by blocking the JNK-dependent pathway.	Tetradecanoylphorbol Acetate	15-18	jun proto-oncogene	Mus musculus	27-46
12645577-2	2003	TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ICAM-1 promoter activity was inhibited by a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2).	Tetradecanoylphorbol Acetate	14-50	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	262-265
12645577-2	2003	TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ICAM-1 promoter activity was inhibited by a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2).	Tetradecanoylphorbol Acetate	52-55	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	262-265
15010455-2	2004	In this report, we have investigated the involvement of the second intracellular loop of the neuronal glycine transporter 2 (GLYT2) on the protein conformational equilibrium and the regulation by 4alpha-phorbol 12 myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	236-239	solute carrier family 6 member 5	Homo sapiens	102-123
12493778-4	2003	We have found MEKK1 to be necessary for uPA up-regulation in response to treatment with phorbol 12-myristate 13-acetate or basic fibroblast growth factor.	Tetradecanoylphorbol Acetate	88-119	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	14-19
15010455-2	2004	In this report, we have investigated the involvement of the second intracellular loop of the neuronal glycine transporter 2 (GLYT2) on the protein conformational equilibrium and the regulation by 4alpha-phorbol 12 myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	236-239	solute carrier family 6 member 5	Homo sapiens	125-130
15064752-4	2004	Previous studies have established that expression of a dominant-negative c-Jun (TAM67) inhibits phorbol 12-tetradecanoyl-13-acetate (TPA)-induced AP-1 transactivation as well as transformation in mouse epidermal JB6/P+ cells and tumor promotion in mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	133-136	jun proto-oncogene	Mus musculus	73-78
12586343-7	2003	Phorbol-12-myristate-13-acetate significantly reduced the induction of apoptosis, inhibiting caspase 3 cleavage, Bax accumulation, Bcl-xL down-regulation as well as restoring cell viability.	Tetradecanoylphorbol Acetate	0-31	caspase 3	Rattus norvegicus	93-102
12586343-7	2003	Phorbol-12-myristate-13-acetate significantly reduced the induction of apoptosis, inhibiting caspase 3 cleavage, Bax accumulation, Bcl-xL down-regulation as well as restoring cell viability.	Tetradecanoylphorbol Acetate	0-31	Bcl2-like 1	Rattus norvegicus	131-137
12612445-2	2003	Expression of the NP95 gene, which was previously found to be the gene of a murine nuclear protein associated with cell proliferation, was increased in the cultures treated by 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and orthovanadate.	Tetradecanoylphorbol Acetate	176-212	ubiquitin-like, containing PHD and RING finger domains, 1	Mus musculus	18-22
12612445-2	2003	Expression of the NP95 gene, which was previously found to be the gene of a murine nuclear protein associated with cell proliferation, was increased in the cultures treated by 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and orthovanadate.	Tetradecanoylphorbol Acetate	214-217	ubiquitin-like, containing PHD and RING finger domains, 1	Mus musculus	18-22
15121014-14	2004	IPA, TPA, and DPA produced 2- to 6-fold increases in COX-2 expression.	Tetradecanoylphorbol Acetate	5-8	cytochrome c oxidase II, mitochondrial	Mus musculus	53-58
12577308-3	2003	In this study, it was demonstrated that the tumor promoter, TPA (12-O-tetradecanoylphorbol-13-acetate) significantly up-regulated NRP1 mRNA levels by increasing its gene transcription rate in a manner dependent on de novo protein synthesis.	Tetradecanoylphorbol Acetate	60-63	neuropilin 1	Homo sapiens	130-134
12577308-3	2003	In this study, it was demonstrated that the tumor promoter, TPA (12-O-tetradecanoylphorbol-13-acetate) significantly up-regulated NRP1 mRNA levels by increasing its gene transcription rate in a manner dependent on de novo protein synthesis.	Tetradecanoylphorbol Acetate	65-101	neuropilin 1	Homo sapiens	130-134
12577308-5	2003	Promoter-reporter gene transfection experiments using deletion and point mutations demonstrated that two Sp1 elements are major contributors to both the constitutive and TPA-induced activity of the NRP1 promoter.	Tetradecanoylphorbol Acetate	170-173	neuropilin 1	Homo sapiens	198-202
12577308-7	2003	Further mutational analysis revealed that an AP-1, and a CCAAT box also contributed to NRP1 constitutive and TPA-induced promoter activity.	Tetradecanoylphorbol Acetate	109-112	neuropilin 1	Homo sapiens	87-91
12581266-8	2003	After controlling for age, both PAI-1 and tPA-PAI-1 showed significant negative correlations with HDL-cholesterol, and positive correlations with triglycerides, WHR, HbA1 and fibrinogen.	Tetradecanoylphorbol Acetate	42-45	hemoglobin subunit alpha 1	Homo sapiens	166-170
12427758-6	2003	Either the depletion of protein kinase C (PKC) by prolonged treatment with phorbol 12-myristate 13-acetate or the inhibition of PKC by the specific inhibitor H7 attenuated the H(2)O(2)-induced activation of JNK1 and apoptosis in control cells but not in the GnT-III transfectants.	Tetradecanoylphorbol Acetate	75-106	protein kinase C delta	Homo sapiens	42-45
12644307-5	2003	Raf-1 and B-Raf, but not A-Raf, were activated by EGF (10 ng/ml) and the pharmacological protein kinase C (PKC) activator phorbol myristate acetate (PMA, 20 nM).	Tetradecanoylphorbol Acetate	122-147	RAF1	Bos taurus	0-5
15140465-8	2004	We also confirmed (using forskolin (20 microM) and phorbol 12-myristate 13-acetate (TPA) (100 nM)) that adenylate cyclase and protein kinase C participate in the downstream signaling responsible for the stimulation of BDNF synthesis, whereas in the regulation of NGF synthesis only the participation of protein kinase C was confirmed.	Tetradecanoylphorbol Acetate	84-87	nerve growth factor	Rattus norvegicus	263-266
12644307-5	2003	Raf-1 and B-Raf, but not A-Raf, were activated by EGF (10 ng/ml) and the pharmacological protein kinase C (PKC) activator phorbol myristate acetate (PMA, 20 nM).	Tetradecanoylphorbol Acetate	122-147	B-Raf proto-oncogene, serine/threonine kinase	Bos taurus	10-15
12644307-5	2003	Raf-1 and B-Raf, but not A-Raf, were activated by EGF (10 ng/ml) and the pharmacological protein kinase C (PKC) activator phorbol myristate acetate (PMA, 20 nM).	Tetradecanoylphorbol Acetate	149-152	RAF1	Bos taurus	0-5
12644307-5	2003	Raf-1 and B-Raf, but not A-Raf, were activated by EGF (10 ng/ml) and the pharmacological protein kinase C (PKC) activator phorbol myristate acetate (PMA, 20 nM).	Tetradecanoylphorbol Acetate	149-152	B-Raf proto-oncogene, serine/threonine kinase	Bos taurus	10-15
12451591-5	2003	Treatment of neutrophils with agents that selectively activate PKC [4beta-phorbol 12-myristate 13-acetate (PMA) ] or cellular Ca(2+) (ionophore A23187) also triggered dephosphorylation of cofilin.	Tetradecanoylphorbol Acetate	68-105	cofilin 1	Homo sapiens	188-195
12451591-5	2003	Treatment of neutrophils with agents that selectively activate PKC [4beta-phorbol 12-myristate 13-acetate (PMA) ] or cellular Ca(2+) (ionophore A23187) also triggered dephosphorylation of cofilin.	Tetradecanoylphorbol Acetate	107-110	cofilin 1	Homo sapiens	188-195
12496186-5	2003	Reverse transcription-PCR and Western blot analysis demonstrated that the human mast cells (HMC-1) express CCL20 mRNA and are able to produce a significant amount (32.4 ng/ml) of CCL20 protein following stimulation by calcium ionophore and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	240-265	C-C motif chemokine ligand 20	Homo sapiens	179-184
14970215-5	2004	Phorbol 12-myristate 13-acetate (PMA) promotes PKC delta translocation to membranes and phosphorylation at Tyr(311).	Tetradecanoylphorbol Acetate	0-31	protein kinase C delta	Homo sapiens	47-56
12469196-1	2003	In the present study, phorbol 12-myristate 13-acetate (PMA) was found to increase secretion of matrix metalloproteinase (MMP)-9 and in vitro invasion in bovine capillary endothelial (BCE) cells, which were blocked by specific inhibitors of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	22-53	matrix metallopeptidase 9	Bos taurus	95-127
12469196-1	2003	In the present study, phorbol 12-myristate 13-acetate (PMA) was found to increase secretion of matrix metalloproteinase (MMP)-9 and in vitro invasion in bovine capillary endothelial (BCE) cells, which were blocked by specific inhibitors of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	55-58	matrix metallopeptidase 9	Bos taurus	95-127
12669231-9	2003	The expression of CD14 and MPO in HL-60 leukemia cells overexpressing GMPR2 clearly increased after induction by TPA.	Tetradecanoylphorbol Acetate	113-116	CD14 molecule	Homo sapiens	18-22
12628505-6	2003	In another experiment, Rg(3) pretreatment abrogated the expression of cyclooxygenase-2 in TPA-stimulated mouse skin.	Tetradecanoylphorbol Acetate	90-93	prostaglandin-endoperoxide synthase 2	Mus musculus	70-86
14970215-5	2004	Phorbol 12-myristate 13-acetate (PMA) promotes PKC delta translocation to membranes and phosphorylation at Tyr(311).	Tetradecanoylphorbol Acetate	33-36	protein kinase C delta	Homo sapiens	47-56
12480917-7	2002	MT1-MMP function at the cell surface was also accelerated by treatment of cells with cytochalasin D, an inhibitor of actin filaments, PMA, a stimulator of protein kinase C, and bafilomycin A(1), an inhibitor of lysosome/endosome function.	Tetradecanoylphorbol Acetate	134-137	matrix metallopeptidase 14	Homo sapiens	0-7
15063796-1	2004	In mouse epidermis in vivo, the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) increases gene expression of matrix metalloproteinase-13 (MMP-13), an enzyme implicated in carcinogenesis.	Tetradecanoylphorbol Acetate	47-83	matrix metallopeptidase 13	Mus musculus	119-146
15063796-1	2004	In mouse epidermis in vivo, the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) increases gene expression of matrix metalloproteinase-13 (MMP-13), an enzyme implicated in carcinogenesis.	Tetradecanoylphorbol Acetate	47-83	matrix metallopeptidase 13	Mus musculus	148-154
15063796-1	2004	In mouse epidermis in vivo, the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) increases gene expression of matrix metalloproteinase-13 (MMP-13), an enzyme implicated in carcinogenesis.	Tetradecanoylphorbol Acetate	85-88	matrix metallopeptidase 13	Mus musculus	119-146
15063796-1	2004	In mouse epidermis in vivo, the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) increases gene expression of matrix metalloproteinase-13 (MMP-13), an enzyme implicated in carcinogenesis.	Tetradecanoylphorbol Acetate	85-88	matrix metallopeptidase 13	Mus musculus	148-154
12446786-2	2002	Conditional expression of C/EBPalpha triggers neutrophilic differentiation, and C/EBPalpha can block 12-O-tetradecanoylphorbol-13-acetate-induced monocytic differentiation of bipotential myeloid cells.	Tetradecanoylphorbol Acetate	101-137	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	80-90
12543062-0	2003	Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.	Tetradecanoylphorbol Acetate	61-64	nuclear receptor subfamily 4, group A, member 3	Mus musculus	47-52
15063796-2	2004	Here we used a keratinocyte cell line (308) derived from initiated mouse skin to investigate TPA-induced MMP-13 gene expression.	Tetradecanoylphorbol Acetate	93-96	matrix metallopeptidase 13	Mus musculus	105-111
15063796-3	2004	Use of a pharmacological inhibitor (U0126) demonstrated that extracellular signal regulated kinase (ERK) plays a major role in TPA-induced MMP-13 gene expression.	Tetradecanoylphorbol Acetate	127-130	matrix metallopeptidase 13	Mus musculus	139-145
15063796-6	2004	TPA stimulated ERK-dependent increases in c-Fos protein and the c-Fos content of AP-1 complexes.	Tetradecanoylphorbol Acetate	0-3	jun proto-oncogene	Mus musculus	81-85
14694601-3	2002	RESULTS: Western-blot analyses of SiO2- and phorbol 12-myristate 13-acetate(TPA)-treated CCL-64 cells showed the same phosphorylation states of Cx43 as the control group.	Tetradecanoylphorbol Acetate	44-75	gap junction protein alpha 1	Homo sapiens	144-148
15063796-7	2004	MMP-13 promoter studies indicated that TPA requires AP-1, but not Runx, to induce MMP-13 gene expression.	Tetradecanoylphorbol Acetate	39-42	matrix metallopeptidase 13	Mus musculus	0-6
14694601-3	2002	RESULTS: Western-blot analyses of SiO2- and phorbol 12-myristate 13-acetate(TPA)-treated CCL-64 cells showed the same phosphorylation states of Cx43 as the control group.	Tetradecanoylphorbol Acetate	76-79	gap junction protein alpha 1	Homo sapiens	144-148
15063796-7	2004	MMP-13 promoter studies indicated that TPA requires AP-1, but not Runx, to induce MMP-13 gene expression.	Tetradecanoylphorbol Acetate	39-42	jun proto-oncogene	Mus musculus	52-56
15063796-7	2004	MMP-13 promoter studies indicated that TPA requires AP-1, but not Runx, to induce MMP-13 gene expression.	Tetradecanoylphorbol Acetate	39-42	matrix metallopeptidase 13	Mus musculus	82-88
14705967-8	2004	While proMBP overexpression led to the formation of a covalent proMBP-PAPP-A complex and reduced the migration of PAPP-A on SDS/PAGE, TPA treatment dose- and time-dependently increased the conversion of a approximately 470 kDa PAPP-A form (PAPP-A470) to a approximately 400 kDa PAPP-A form (PAPP-A400).	Tetradecanoylphorbol Acetate	134-137	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	6-12
12359735-6	2002	In vivo phosphorylation studies using (32)P(i)-labeled mesangial cells revealed that TPA, PDGF, angiotensin II, and ATP trigger an increased phosphorylation of the neutral ceramidase, which is blocked by the broad spectrum PKC inhibitor Ro-31 8220 but not by CGP 41251, which has a preferential action on Ca(2+)-dependent isoforms, thus suggesting the involvement of a Ca(2+)-independent PKC isoform.	Tetradecanoylphorbol Acetate	85-88	N-acylsphingosine amidohydrolase 2	Rattus norvegicus	164-182
12228223-8	2002	Differentiation of cultured primary epidermal keratinocytes with 0.12 mm Ca(2+) or 12-O-tetradecanoylphorbol-13-acetate treatment resulted in the induction of suprabasin.	Tetradecanoylphorbol Acetate	83-119	suprabasin	Mus musculus	159-169
14705967-8	2004	While proMBP overexpression led to the formation of a covalent proMBP-PAPP-A complex and reduced the migration of PAPP-A on SDS/PAGE, TPA treatment dose- and time-dependently increased the conversion of a approximately 470 kDa PAPP-A form (PAPP-A470) to a approximately 400 kDa PAPP-A form (PAPP-A400).	Tetradecanoylphorbol Acetate	134-137	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	63-69
12376314-7	2002	Therefore, stimulation of insulin secretion by PMA, and presumably by endogenous diacylglycerol, involves the activation of PKC isoforms delta and/or mu, and also PKC-alpha.	Tetradecanoylphorbol Acetate	47-50	protein kinase C delta	Homo sapiens	124-142
14705967-8	2004	While proMBP overexpression led to the formation of a covalent proMBP-PAPP-A complex and reduced the migration of PAPP-A on SDS/PAGE, TPA treatment dose- and time-dependently increased the conversion of a approximately 470 kDa PAPP-A form (PAPP-A470) to a approximately 400 kDa PAPP-A form (PAPP-A400).	Tetradecanoylphorbol Acetate	134-137	pappalysin 1	Homo sapiens	70-76
14705967-8	2004	While proMBP overexpression led to the formation of a covalent proMBP-PAPP-A complex and reduced the migration of PAPP-A on SDS/PAGE, TPA treatment dose- and time-dependently increased the conversion of a approximately 470 kDa PAPP-A form (PAPP-A470) to a approximately 400 kDa PAPP-A form (PAPP-A400).	Tetradecanoylphorbol Acetate	134-137	pappalysin 1	Homo sapiens	114-120
14705967-8	2004	While proMBP overexpression led to the formation of a covalent proMBP-PAPP-A complex and reduced the migration of PAPP-A on SDS/PAGE, TPA treatment dose- and time-dependently increased the conversion of a approximately 470 kDa PAPP-A form (PAPP-A470) to a approximately 400 kDa PAPP-A form (PAPP-A400).	Tetradecanoylphorbol Acetate	134-137	pappalysin 1	Homo sapiens	114-120
14705967-8	2004	While proMBP overexpression led to the formation of a covalent proMBP-PAPP-A complex and reduced the migration of PAPP-A on SDS/PAGE, TPA treatment dose- and time-dependently increased the conversion of a approximately 470 kDa PAPP-A form (PAPP-A470) to a approximately 400 kDa PAPP-A form (PAPP-A400).	Tetradecanoylphorbol Acetate	134-137	pappalysin 1	Homo sapiens	114-120
12414636-5	2002	Up-regulation of integrin alpha2 by phorbol 12-myristate 13-acetate abrogated the inhibitory effect of E7820 on tube formation within type I collagen gel, whereas addition of antibody against integrin alpha2 canceled the phorbol 12-myristate 13-acetate effect.	Tetradecanoylphorbol Acetate	36-67	integrin subunit alpha 2	Homo sapiens	17-32
12414636-5	2002	Up-regulation of integrin alpha2 by phorbol 12-myristate 13-acetate abrogated the inhibitory effect of E7820 on tube formation within type I collagen gel, whereas addition of antibody against integrin alpha2 canceled the phorbol 12-myristate 13-acetate effect.	Tetradecanoylphorbol Acetate	221-252	integrin subunit alpha 2	Homo sapiens	17-32
12414636-5	2002	Up-regulation of integrin alpha2 by phorbol 12-myristate 13-acetate abrogated the inhibitory effect of E7820 on tube formation within type I collagen gel, whereas addition of antibody against integrin alpha2 canceled the phorbol 12-myristate 13-acetate effect.	Tetradecanoylphorbol Acetate	221-252	integrin subunit alpha 2	Homo sapiens	192-207
12082101-3	2002	In the present study, we found that the exposure of myeloblastic leukemia ML-1 cells to UV light (UVC) caused a significant increase in junD mRNA expression within 5 min that persisted for a period of 3 h. The activation of protein kinase C (PKC) with 12-O-tetradecaoylphorbol-13-acetate (TPA) also induced increases in junD expression similar to those of UV irradiation.	Tetradecanoylphorbol Acetate	289-292	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-140
14705967-11	2004	These data suggest that a novel mechanism, namely conversion of PAPP-A470 to the less-active PAPP-A400, could account for the TPA-induced suppression of PAPP-A activity.	Tetradecanoylphorbol Acetate	126-129	pappalysin 1	Homo sapiens	64-70
12082101-4	2002	In addition, UV irradiation- and TPA-induced increases in junD expression were completely abolished by GF-109203X, a PKC-specific inhibitor.	Tetradecanoylphorbol Acetate	33-36	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-62
14705967-11	2004	These data suggest that a novel mechanism, namely conversion of PAPP-A470 to the less-active PAPP-A400, could account for the TPA-induced suppression of PAPP-A activity.	Tetradecanoylphorbol Acetate	126-129	pappalysin 1	Homo sapiens	93-99
12082101-8	2002	The overexpression of MEK1 enhanced substantially junD expression in response to UV or TPA.	Tetradecanoylphorbol Acetate	87-90	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-54
12082101-9	2002	In contrast, the suppression of Erk activation with PD98059, a specific inhibitor of MEK1, inhibited UV- and TPA-induced junD mRNA expression, UV-induced increases in caspase-3 activities, and cell death.	Tetradecanoylphorbol Acetate	109-112	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	121-125
15034076-9	2004	Stimulation of T cells from nonpregnant females with PMA/ionomycin resulted in IkappaBalpha degradation, p65 translocation, and subsequent production of the Th1 cytokines IFN-gamma and IL-2.	Tetradecanoylphorbol Acetate	53-56	RELA proto-oncogene, NF-kB subunit	Homo sapiens	105-108
12181747-4	2002	In Jurkat cells, TPA strongly activated ERK and inhibited the IR-induced caspase-8/Bid cleavage and the loss of DeltaPsi(m).	Tetradecanoylphorbol Acetate	17-20	caspase 8	Homo sapiens	73-82
15047839-0	2004	Early activation of the Kaposi"s sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway.	Tetradecanoylphorbol Acetate	99-128	RNA binding fox-1 homolog 2	Homo sapiens	64-67
12009309-2	2002	Although TPA-induced OPN expression in JB6 cells has been suggested to involve protein kinase C (PKC), the PKC isoforms and the downstream pathway mediating OPN expression have not been extensively studied.	Tetradecanoylphorbol Acetate	9-12	protein kinase C delta	Homo sapiens	97-100
12009309-3	2002	METHODS: Using the JB6 cell model, we determined the involvement of PKC isoforms, mitogen-activated protein kinase kinase (MAPK kinase/MEK) and MAPK in TPA-induced OPN expression using inhibitors specific to PKC isoforms and MEK and performing Northern blot analyses.	Tetradecanoylphorbol Acetate	152-155	protein kinase C delta	Homo sapiens	68-71
12009309-3	2002	METHODS: Using the JB6 cell model, we determined the involvement of PKC isoforms, mitogen-activated protein kinase kinase (MAPK kinase/MEK) and MAPK in TPA-induced OPN expression using inhibitors specific to PKC isoforms and MEK and performing Northern blot analyses.	Tetradecanoylphorbol Acetate	152-155	protein kinase C delta	Homo sapiens	208-211
15047839-3	2004	The cellular CCAAT/enhancer-binding protein alpha (C/EBP alpha) is induced in TPA-treated PEL cells and contributes to transactivation of the promoters for all of these genes through both direct binding and cooperative interactions with RTA and RAP targeted to upstream C/EBP sites.	Tetradecanoylphorbol Acetate	78-81	RNA binding fox-1 homolog 2	Homo sapiens	237-240
12009309-6	2002	TPA induction of OPN expression in JB6 cells is mediated through PKC epsilon and PKC delta, which also mediated the phosphorylation of MAPK.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	81-90
12009309-9	2002	CONCLUSION: TPA-induced steady-state OPN mRNA expression in mouse JB6 cells involves the activation of MAPK mediated through PKC epsilon and/or PKC delta.	Tetradecanoylphorbol Acetate	12-15	secreted phosphoprotein 1	Mus musculus	37-40
15047839-4	2004	However, little is known about how RTA expression is triggered initially at the earliest stages after TPA induction when the C/EBP alpha levels are still limited.	Tetradecanoylphorbol Acetate	102-105	RNA binding fox-1 homolog 2	Homo sapiens	35-38
12009309-9	2002	CONCLUSION: TPA-induced steady-state OPN mRNA expression in mouse JB6 cells involves the activation of MAPK mediated through PKC epsilon and/or PKC delta.	Tetradecanoylphorbol Acetate	12-15	protein kinase C delta	Homo sapiens	144-153
15047839-5	2004	Treatment with TPA proved to significantly induce both AP1 DNA-binding activity and levels of activated phosphorylated cJUN in PEL cells and ectopic expression of cJUN-plus-cFOS-induced RTA protein expression in PEL cells.	Tetradecanoylphorbol Acetate	15-18	RNA binding fox-1 homolog 2	Homo sapiens	186-189
15047839-6	2004	Cotransfected cJUN plus cFOS or TPA treatment transactivated the KSHV RTA, RAP, and MTA promoters in an AP1-binding site-dependent manner in all three promoters.	Tetradecanoylphorbol Acetate	32-35	RNA binding fox-1 homolog 2	Homo sapiens	70-73
15144607-7	2004	(3) There was a positive correlation between the positive rate of nucleolar staining for NF-kappaB p65, the relative expression of VEGF protein and the percentage of G(2)/M phases of cell cycle in hypoxia PMA group (r = 0.587 - 0.710, P &lt; 0.05, respectively).	Tetradecanoylphorbol Acetate	205-208	RELA proto-oncogene, NF-kB subunit	Homo sapiens	99-102
12211438-9	2002	The direct PKC stimulator 12-O-tetradecanoylphorbol-13-acetate (PMA) did not induce RANKL mRNA in MS1 cells, but it did up-regulate OPG mRNA and also antagonized osteoclast formation induced by PTH(1-34) in both MS1/spleen cocultures and normal bone marrow cultures.	Tetradecanoylphorbol Acetate	26-62	parathyroid hormone	Mus musculus	194-197
12211438-9	2002	The direct PKC stimulator 12-O-tetradecanoylphorbol-13-acetate (PMA) did not induce RANKL mRNA in MS1 cells, but it did up-regulate OPG mRNA and also antagonized osteoclast formation induced by PTH(1-34) in both MS1/spleen cocultures and normal bone marrow cultures.	Tetradecanoylphorbol Acetate	64-67	parathyroid hormone	Mus musculus	194-197
14699137-3	2004	We report here that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate prevents DNA damage-induced up-regulation of p53 by down-regulating PKC delta.	Tetradecanoylphorbol Acetate	54-90	protein kinase C delta	Homo sapiens	159-168
12072430-8	2002	We further show that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases BCSG1 mRNA expression and up-regulates BCSG1 promoter activity through the intronic AP1 sites.	Tetradecanoylphorbol Acetate	21-57	synuclein gamma	Homo sapiens	74-79
12072430-8	2002	We further show that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases BCSG1 mRNA expression and up-regulates BCSG1 promoter activity through the intronic AP1 sites.	Tetradecanoylphorbol Acetate	21-57	synuclein gamma	Homo sapiens	113-118
12072430-8	2002	We further show that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases BCSG1 mRNA expression and up-regulates BCSG1 promoter activity through the intronic AP1 sites.	Tetradecanoylphorbol Acetate	59-62	synuclein gamma	Homo sapiens	74-79
12072430-8	2002	We further show that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases BCSG1 mRNA expression and up-regulates BCSG1 promoter activity through the intronic AP1 sites.	Tetradecanoylphorbol Acetate	59-62	synuclein gamma	Homo sapiens	113-118
12072430-9	2002	The effect of TPA on BCSG1 transcription is also demonstrated under in vivo conditions in intact cells by using chromatin immunoprecipitation assays that show the TPA-induced binding of c-Jun to the chromatin region encompassing the intronic AP1 sites.	Tetradecanoylphorbol Acetate	14-17	synuclein gamma	Homo sapiens	21-26
12072430-9	2002	The effect of TPA on BCSG1 transcription is also demonstrated under in vivo conditions in intact cells by using chromatin immunoprecipitation assays that show the TPA-induced binding of c-Jun to the chromatin region encompassing the intronic AP1 sites.	Tetradecanoylphorbol Acetate	163-166	synuclein gamma	Homo sapiens	21-26
14661062-0	2004	Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction.	Tetradecanoylphorbol Acetate	21-46	protein kinase C delta	Homo sapiens	115-124
12052829-3	2002	In this work, we have identified 12-O-tetradecanoylphorbol-13-acetate (TPA)- and growth factor-induced serine/threonine phosphorylation sites in p52(Shc) and p66(Shc).	Tetradecanoylphorbol Acetate	33-69	similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52)	Rattus norvegicus	145-148
12052829-3	2002	In this work, we have identified 12-O-tetradecanoylphorbol-13-acetate (TPA)- and growth factor-induced serine/threonine phosphorylation sites in p52(Shc) and p66(Shc).	Tetradecanoylphorbol Acetate	71-74	similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52)	Rattus norvegicus	145-148
12052829-4	2002	Among them, Ser(29) in p52(Shc) (equivalent to Ser(138) in p66(Shc)) was phosphorylated only after TPA stimulation.	Tetradecanoylphorbol Acetate	99-102	similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52)	Rattus norvegicus	23-26
14661062-7	2004	Resveratrol inhibited PMA-mediated activation of c-Jun N-terminal kinase (JNK) and protein kinase C (PKC)-delta activation.	Tetradecanoylphorbol Acetate	22-25	protein kinase C delta	Homo sapiens	83-111
14661063-6	2004	TPA-induced c-Jun expression was transient in TNFR1-/- and TNFR2-/- compared to wt epidermis and this was reflected by reduced induction of the AP-1-responsive genes granulocyte/macrophage-colony stimulating factor, matrix metalloproteinase-9 and matrix metalloproteinase-3.	Tetradecanoylphorbol Acetate	0-3	jun proto-oncogene	Mus musculus	12-17
12180971-1	2002	Our laboratory showed that bikunin, a Kunitz-type protease inhibitor, suppresses 4beta-phorbol 12-myristate 13-acetate (PMA)- or tumor necrosis factor-alpha (TNFalpha)-induced urokinase-type plasminogen activator (uPA) expression in different cell types.	Tetradecanoylphorbol Acetate	81-118	alpha-1-microglobulin/bikunin precursor	Homo sapiens	27-34
15104238-4	2004	High glucose (20 mM) and phorbol-myristate-acetate (PMA)-induced endothelial hyperpermeability was almost abolished by 150 nM HA and partially reduced by 30 nM PKC beta inhibitor (LY379196).	Tetradecanoylphorbol Acetate	25-50	protein kinase C beta	Homo sapiens	160-168
12180971-1	2002	Our laboratory showed that bikunin, a Kunitz-type protease inhibitor, suppresses 4beta-phorbol 12-myristate 13-acetate (PMA)- or tumor necrosis factor-alpha (TNFalpha)-induced urokinase-type plasminogen activator (uPA) expression in different cell types.	Tetradecanoylphorbol Acetate	120-123	alpha-1-microglobulin/bikunin precursor	Homo sapiens	27-34
15104238-4	2004	High glucose (20 mM) and phorbol-myristate-acetate (PMA)-induced endothelial hyperpermeability was almost abolished by 150 nM HA and partially reduced by 30 nM PKC beta inhibitor (LY379196).	Tetradecanoylphorbol Acetate	52-55	protein kinase C beta	Homo sapiens	160-168
14647238-9	2004	In gene reporter experiments, HPR stimulated AP-1 transcriptional activity and potentiated the AP-1 activity induced by 12-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	120-154	haptoglobin-related protein	Homo sapiens	30-33
12184631-1	2002	Here, we demonstrate the possible involvement of oxidative stress in altered CD13/aminopeptidase N (APN) expression during myeloid cell differentiation induced by TPA.	Tetradecanoylphorbol Acetate	163-166	alanyl aminopeptidase, membrane	Homo sapiens	77-81
12184631-1	2002	Here, we demonstrate the possible involvement of oxidative stress in altered CD13/aminopeptidase N (APN) expression during myeloid cell differentiation induced by TPA.	Tetradecanoylphorbol Acetate	163-166	alanyl aminopeptidase, membrane	Homo sapiens	82-98
12184631-1	2002	Here, we demonstrate the possible involvement of oxidative stress in altered CD13/aminopeptidase N (APN) expression during myeloid cell differentiation induced by TPA.	Tetradecanoylphorbol Acetate	163-166	alanyl aminopeptidase, membrane	Homo sapiens	100-103
12184631-3	2002	When the cells were treated with TPA, CD13/APN expression was up-regulated with increased intracellular peroxides and a morphological change into macrophage-like cells.	Tetradecanoylphorbol Acetate	33-36	alanyl aminopeptidase, membrane	Homo sapiens	38-42
12184631-3	2002	When the cells were treated with TPA, CD13/APN expression was up-regulated with increased intracellular peroxides and a morphological change into macrophage-like cells.	Tetradecanoylphorbol Acetate	33-36	alanyl aminopeptidase, membrane	Homo sapiens	43-46
14978237-2	2004	The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2.	Tetradecanoylphorbol Acetate	171-174	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	315-318
12184631-7	2002	These results indicate that the change in intracellular redox state could be involved in the up-regulation of CD13/APN expression during TPA-induced differentiation of HL-60 cells, suggesting that TNFalpha may serve as, at least, one of the signals stimulated by TPA.	Tetradecanoylphorbol Acetate	137-140	alanyl aminopeptidase, membrane	Homo sapiens	110-114
12184631-7	2002	These results indicate that the change in intracellular redox state could be involved in the up-regulation of CD13/APN expression during TPA-induced differentiation of HL-60 cells, suggesting that TNFalpha may serve as, at least, one of the signals stimulated by TPA.	Tetradecanoylphorbol Acetate	137-140	alanyl aminopeptidase, membrane	Homo sapiens	115-118
14981400-9	2004	Exposure to TPA for 5 and 30 minutes induced translocation of PKC alpha and PKC delta, respectively.	Tetradecanoylphorbol Acetate	12-15	protein kinase C delta	Homo sapiens	76-85
12184631-7	2002	These results indicate that the change in intracellular redox state could be involved in the up-regulation of CD13/APN expression during TPA-induced differentiation of HL-60 cells, suggesting that TNFalpha may serve as, at least, one of the signals stimulated by TPA.	Tetradecanoylphorbol Acetate	263-266	alanyl aminopeptidase, membrane	Homo sapiens	110-114
14514518-5	2004	Forskolin (10 microM), a stimulator of adenylate cyclase and an activator of cAMP, opened BKCa channels in single FHR PASMC, which were blocked by the PKC activators phorbol 12-myristate 13-acetate (100 nM) and thymeleatoxin (100 nM).	Tetradecanoylphorbol Acetate	166-197	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	90-94
12176659-6	2002	AT1 desensitisation was demonstrated with respect to the Ca(2+) response after subsequent exposure of cells to Ang II and also after pretreatment for 25 min with 1000 nM phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	170-201	angiotensin II receptor type 1	Homo sapiens	0-3
12441351-6	2003	MUC1 release was stimulated by phorbol 12-myristate 13-acetate and was markedly inhibited by the synthetic peptide hydroxamate metalloprotease inhibitor, tumor necrosis factor-alpha protease inhibitor (TAPI), as well as by an endogenous inhibitor of matrix metalloproteases, tissue inhibitor of metalloproteases (TIMP)-3.	Tetradecanoylphorbol Acetate	31-62	mucin 1, cell surface associated	Homo sapiens	0-4
15630166-4	2004	Topical application of [6]-gingerol inhibited phorbol 12-myristate 13-acetate -induced COX-2 expression.	Tetradecanoylphorbol Acetate	46-77	prostaglandin-endoperoxide synthase 2	Mus musculus	87-92
12126964-5	2002	6 h of phorbol 12-myristate 13-acetate (PMA) stimulation caused a decrease of AT(1)-mRNA level.	Tetradecanoylphorbol Acetate	7-38	angiotensin II receptor, type 1a	Rattus norvegicus	78-83
12126964-5	2002	6 h of phorbol 12-myristate 13-acetate (PMA) stimulation caused a decrease of AT(1)-mRNA level.	Tetradecanoylphorbol Acetate	40-43	angiotensin II receptor, type 1a	Rattus norvegicus	78-83
15630167-3	2004	Since an abnormally elevated level of cyclooxygenase-2 (COX-2) has been implicated in carcinogenesis, we investigated the effect of resveratrol on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 expression in mouse skin.	Tetradecanoylphorbol Acetate	147-183	prostaglandin-endoperoxide synthase 2	Mus musculus	198-203
15630167-4	2004	Pretreatment of dorsal skin of female ICR mice with resveratrol inhibited TPA-induced COX-2 expression in a dose dependent manner.	Tetradecanoylphorbol Acetate	74-77	prostaglandin-endoperoxide synthase 2	Mus musculus	86-91
15630167-5	2004	To elucidate the molecular mechanism underlying COX-2 inhibition by resveratrol, we examined its effect on TPA-induced activation of mitogen-activated protein kinases (MAPK) and transcription factors which regulate COX-2 expression.	Tetradecanoylphorbol Acetate	107-110	prostaglandin-endoperoxide synthase 2	Mus musculus	215-220
12567182-11	2003	Intercellular communication is inhibited by TPA and can be restored by proteasome inhibitors, probably by preventing loss of Cx43 from the plasma membrane following treatment with TPA.	Tetradecanoylphorbol Acetate	44-47	gap junction protein alpha 1	Homo sapiens	125-129
15630167-7	2004	In addition, resveratrol prevented TPA-induced DNA binding of activator protein-1 (AP-1).	Tetradecanoylphorbol Acetate	35-38	jun proto-oncogene	Mus musculus	62-81
12567182-11	2003	Intercellular communication is inhibited by TPA and can be restored by proteasome inhibitors, probably by preventing loss of Cx43 from the plasma membrane following treatment with TPA.	Tetradecanoylphorbol Acetate	180-183	gap junction protein alpha 1	Homo sapiens	125-129
12097169-4	2002	In this study, we examined the expression of PACE4 and furin during the differentiation of megakaryoblastic cell lines, Dami and HEL cells, induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	151-182	furin, paired basic amino acid cleaving enzyme	Homo sapiens	55-60
12097169-4	2002	In this study, we examined the expression of PACE4 and furin during the differentiation of megakaryoblastic cell lines, Dami and HEL cells, induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	184-187	furin, paired basic amino acid cleaving enzyme	Homo sapiens	55-60
15630167-7	2004	In addition, resveratrol prevented TPA-induced DNA binding of activator protein-1 (AP-1).	Tetradecanoylphorbol Acetate	35-38	jun proto-oncogene	Mus musculus	83-87
12433930-8	2003	We demonstrated that c-Fos, c-Jun, and JunD are involved in TPA inhibitory effect due to their ability to bind TRE-ALAS, evidenced by supershift analysis and their capacity to repress promoter activity in transfection assays.	Tetradecanoylphorbol Acetate	60-63	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-43
15327748-5	2004	Treatment with a potent PKC activator, phorbol-12-myristate-13-acetate (PMA), augmented GADD153 mRNA in Jurkat cells in the presence of hydrogen peroxide, although PMA alone induced GADD153 mRNA marginally.	Tetradecanoylphorbol Acetate	39-70	protein kinase C delta	Homo sapiens	24-27
12433930-9	2003	Repression of ALAS promoter activity by TPA treatment or Fos/Jun overexpression was largely relieved when CRE protein-binding protein or p300 was ectopically expressed.	Tetradecanoylphorbol Acetate	40-43	E1A binding protein p300	Homo sapiens	137-141
12433932-4	2003	However, in the present study we found that both piroxicam, a general COX inhibitor, and NS-398, a COX-2 selective inhibitor, effectively suppressed the activation of transcription factor activator protein 1 (AP-1) induced by ultraviolet B (UVB) or 12-O-tetradecanoylphorbol-13-acetate in mouse epidermal JB6 cells.	Tetradecanoylphorbol Acetate	249-285	jun proto-oncogene	Mus musculus	188-207
12134900-6	2002	In addition, PMA-induced downregulation of TIMP-1 and TIMP-2 secretion and upregulation of the membrane type I MMP, a major activator of MMP-2 on the cell surface, were reversed by SB203580 in these cells; the PMA-induced increase of invasion in vitro decreased when SB203580 was added to the top compartment of a modified Boyden chamber; and the inhibitor also reduced the MMP secretion and PMA-induced in vitro invasion in various glioma cell lines.	Tetradecanoylphorbol Acetate	13-16	matrix metallopeptidase 2	Homo sapiens	137-142
12134900-6	2002	In addition, PMA-induced downregulation of TIMP-1 and TIMP-2 secretion and upregulation of the membrane type I MMP, a major activator of MMP-2 on the cell surface, were reversed by SB203580 in these cells; the PMA-induced increase of invasion in vitro decreased when SB203580 was added to the top compartment of a modified Boyden chamber; and the inhibitor also reduced the MMP secretion and PMA-induced in vitro invasion in various glioma cell lines.	Tetradecanoylphorbol Acetate	13-16	matrix metallopeptidase 2	Homo sapiens	111-114
12137745-7	2002	PMA also induced phosphorylation of p44/p42 extracellular signal-regulated kinases (ERK) 1 and 2.	Tetradecanoylphorbol Acetate	0-3	interferon induced protein 44	Homo sapiens	36-39
12433932-4	2003	However, in the present study we found that both piroxicam, a general COX inhibitor, and NS-398, a COX-2 selective inhibitor, effectively suppressed the activation of transcription factor activator protein 1 (AP-1) induced by ultraviolet B (UVB) or 12-O-tetradecanoylphorbol-13-acetate in mouse epidermal JB6 cells.	Tetradecanoylphorbol Acetate	249-285	jun proto-oncogene	Mus musculus	209-213
15327748-5	2004	Treatment with a potent PKC activator, phorbol-12-myristate-13-acetate (PMA), augmented GADD153 mRNA in Jurkat cells in the presence of hydrogen peroxide, although PMA alone induced GADD153 mRNA marginally.	Tetradecanoylphorbol Acetate	72-75	protein kinase C delta	Homo sapiens	24-27
11940578-6	2002	Dominant negative c-Raf expression or a MEK1/2 inhibitor (U0126) treatment showed a profound blocking effect only on the TPA-stimulated phosphorylation of S6K1 and mTOR.	Tetradecanoylphorbol Acetate	121-124	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	18-23
15015228-2	2004	Activated TAFI (TAFIa) reduces a generation of plasmin because it cleaves off the carboxy-terminal lysine residues from partially degraded fibrin and thereby abrogates the fibrin cofactor function in the tPA-mediated catalysis of plasminogen to plasmin.	Tetradecanoylphorbol Acetate	204-207	plasminogen	Homo sapiens	47-54
12075356-4	2002	Here we show that such Tiam1(-/-) mice are resistant to the development of Ras-induced skin tumours initiated with 7,12-dimethylbenzanthracene and promoted with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	161-197	T cell lymphoma invasion and metastasis 1	Mus musculus	23-28
12191496-3	2002	Here we report that secretion and expression of HGF in U87 astrocytoma is increased by a PKC activator, PMA, an effect which is abolished by a PKC inhibitor, Go6976, specific for PKCalpha and PKCbeta1.	Tetradecanoylphorbol Acetate	104-107	hepatocyte growth factor	Homo sapiens	48-51
12527890-0	2003	Differential requirement of EGF receptor and its tyrosine kinase for AP-1 transactivation induced by EGF and TPA.	Tetradecanoylphorbol Acetate	109-112	jun proto-oncogene	Mus musculus	69-73
12527890-2	2003	It is thought that the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 activity is because of the activation of the PKC/MAPK/AP-1 pathway, although the detailed molecular mechanism has not been fully characterized.	Tetradecanoylphorbol Acetate	23-59	jun proto-oncogene	Mus musculus	74-78
12527890-2	2003	It is thought that the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 activity is because of the activation of the PKC/MAPK/AP-1 pathway, although the detailed molecular mechanism has not been fully characterized.	Tetradecanoylphorbol Acetate	23-59	jun proto-oncogene	Mus musculus	133-137
12527890-2	2003	It is thought that the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 activity is because of the activation of the PKC/MAPK/AP-1 pathway, although the detailed molecular mechanism has not been fully characterized.	Tetradecanoylphorbol Acetate	61-64	jun proto-oncogene	Mus musculus	74-78
12527890-2	2003	It is thought that the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 activity is because of the activation of the PKC/MAPK/AP-1 pathway, although the detailed molecular mechanism has not been fully characterized.	Tetradecanoylphorbol Acetate	61-64	jun proto-oncogene	Mus musculus	133-137
12527890-4	2003	Currently, little is known about whether EGFR or its tyrosine kinase is necessary for TPA-induced AP-1 activation.	Tetradecanoylphorbol Acetate	86-89	jun proto-oncogene	Mus musculus	98-102
12039887-13	2002	PMA phosphorylated both p38 and p44/42 MAPK.	Tetradecanoylphorbol Acetate	0-3	interferon induced protein 44	Homo sapiens	32-35
14527959-6	2003	Inhibitors of the Ca2+-independent, novel PKC isoforms, but not inhibitors of MAPK, PI3-kinase, or PKA, blocked PMA-stimulated cIAP-2 mRNA expression, suggesting a role of PKC in PMA-mediated cIAP-2 induction.	Tetradecanoylphorbol Acetate	112-115	protein kinase C delta	Homo sapiens	42-45
14527959-6	2003	Inhibitors of the Ca2+-independent, novel PKC isoforms, but not inhibitors of MAPK, PI3-kinase, or PKA, blocked PMA-stimulated cIAP-2 mRNA expression, suggesting a role of PKC in PMA-mediated cIAP-2 induction.	Tetradecanoylphorbol Acetate	112-115	protein kinase C delta	Homo sapiens	172-175
12023366-6	2002	We found that incubation with low concentrations of crocidolite asbestos (0.5-1.25 microg/cm(2)) resulted in an increase in nuclear Ref-1 protein after 5 min, with a persistent elevation in protein up to 24 h. Additionally, an increase in nuclear Ref-1 could be induced by treating the cells with an oxidant-generating stimulus (iron loading plus PMA) and inhibited by diphenyleneiodonium chloride, an inhibitor of NADPH oxidase.	Tetradecanoylphorbol Acetate	347-350	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	132-137
12960165-6	2003	The p38 MAPK inhibitor SB202190 and overexpression of dominant negative mutants of MAPK kinase 4 (MKK4), MKK6, and p38 inhibited the TPA-dependent induction of Prx I gene transcription.	Tetradecanoylphorbol Acetate	133-136	mitogen activated protein kinase 14	Rattus norvegicus	4-7
12297018-3	2002	In this study, we have found that curcumin inhibits the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced nuclear factor kB (NF-kappaB) activation by preventing the degradation of the inhibitory protein IkBalpa; and the subsequent translocation of the p65 subunit in cultured human promyelocytic leukemia (HL-60) cells.	Tetradecanoylphorbol Acetate	56-92	RELA proto-oncogene, NF-kB subunit	Homo sapiens	253-256
12297018-3	2002	In this study, we have found that curcumin inhibits the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced nuclear factor kB (NF-kappaB) activation by preventing the degradation of the inhibitory protein IkBalpa; and the subsequent translocation of the p65 subunit in cultured human promyelocytic leukemia (HL-60) cells.	Tetradecanoylphorbol Acetate	94-97	RELA proto-oncogene, NF-kB subunit	Homo sapiens	253-256
12054499-4	2002	Signaling cascade studies indicated that both FGF-2 and TPA induced Ras activation, c-Raf phosphorylation, mitogen-activated protein kinase/ERK kinase (MEK(1/2)) phosphorylation, and extracellular signal-regulated kinase (ERK(1/2)) phosphorylation.	Tetradecanoylphorbol Acetate	56-59	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	84-89
12054499-6	2002	A pan-protein kinase C (PKC) inhibitor, GF109203X, was found to totally abolish the FGF-2- and TPA-induced MMP-9 secretion and ERK(1/2) phosphorylation.	Tetradecanoylphorbol Acetate	95-98	protein kinase C delta	Homo sapiens	24-27
12527890-6	2003	We demonstrated that the TPA or epidermal growth factor (EGF) induced AP-1 activation in the B82L cells that express wild-type EGFR, but not in the B82 cell, whereas autophosphorylation at tyrosine(1173) of EGFR in B82L cells was only induced by EGF, but not TPA.	Tetradecanoylphorbol Acetate	25-28	jun proto-oncogene	Mus musculus	70-74
12527890-7	2003	The expression of tyrosine kinase-deficient EGFR (mutation at Lys-721) (B82M721) resulted in deficiency of AP-1 induction in cellular response to EGF, while TPA treatment led to fully AP-1 activation.	Tetradecanoylphorbol Acetate	157-160	jun proto-oncogene	Mus musculus	184-188
12527890-9	2003	Based on these results, we conclude that TPA-induced AP-1 activation requires the basal level-EGFR protein, but not EGFR tyrosine kinase and EGFR autophosphorylation at tyrosine(1173), whereas both EGFR tyrosine kinase and EGFR autophosphorylation at Y(1173) play a critical role in EGF-induced AP-1 activation.	Tetradecanoylphorbol Acetate	41-44	jun proto-oncogene	Mus musculus	53-57
12527890-9	2003	Based on these results, we conclude that TPA-induced AP-1 activation requires the basal level-EGFR protein, but not EGFR tyrosine kinase and EGFR autophosphorylation at tyrosine(1173), whereas both EGFR tyrosine kinase and EGFR autophosphorylation at Y(1173) play a critical role in EGF-induced AP-1 activation.	Tetradecanoylphorbol Acetate	41-44	jun proto-oncogene	Mus musculus	295-299
12908596-0	2003	Finding of TRE (TPA responsive element) in the sequence of human taurine transporter promoter.	Tetradecanoylphorbol Acetate	16-19	solute carrier family 6 member 6	Homo sapiens	65-84
12054499-7	2002	Use of isoform-specific PKC inhibitors such as Rotllerin and Go6976 suggested, moreover, that the PKC-delta isoform is a likely component of FGF-2 and TPA trophic signaling.	Tetradecanoylphorbol Acetate	151-154	protein kinase C delta	Homo sapiens	24-27
12054499-7	2002	Use of isoform-specific PKC inhibitors such as Rotllerin and Go6976 suggested, moreover, that the PKC-delta isoform is a likely component of FGF-2 and TPA trophic signaling.	Tetradecanoylphorbol Acetate	151-154	protein kinase C delta	Homo sapiens	98-107
12054499-8	2002	These results demonstrated that FGF-2 and TPA induce MMP-9 secretion in MCF-7 cells mainly through PKC-dependent activation of the Ras/ERK(1/2) signaling pathway.	Tetradecanoylphorbol Acetate	42-45	protein kinase C delta	Homo sapiens	99-102
12082627-5	2002	The AP-1 activator phorbol 12-myristate 13-acetate (TPA) enhanced the binding of this DR4 AP-1 binding site to protein(s) in a nuclear extract from TPA-treated cells, increased luciferase activity of a reporter construct containing this site and induced DR4 expression at the transcription level.	Tetradecanoylphorbol Acetate	19-50	TNF receptor superfamily member 10a	Homo sapiens	86-89
11825899-4	2002	A CCAAT/enhancer-binding protein (C/EBP) binding site located at +22 to +30 was bound by C/EBP beta in a TPA-dependent manner and was solely responsible for the TPA responsiveness.	Tetradecanoylphorbol Acetate	105-108	CCAAT enhancer binding protein beta	Homo sapiens	89-99
12813560-12	2003	We also showed that TPA and Cal C treatment had an influence on the subcellular distribution of syndecan-4, but there was no influence on myoblast differentiation.	Tetradecanoylphorbol Acetate	20-23	syndecan 4	Homo sapiens	96-106
12960165-6	2003	The p38 MAPK inhibitor SB202190 and overexpression of dominant negative mutants of MAPK kinase 4 (MKK4), MKK6, and p38 inhibited the TPA-dependent induction of Prx I gene transcription.	Tetradecanoylphorbol Acetate	133-136	mitogen activated protein kinase 14	Rattus norvegicus	115-118
12813560-13	2003	We speculated that the reason for changes after TPA treatment was the interactions with activated PKC alpha, which provoked syndecan-4/PKC alpha complex translocation to integrins.	Tetradecanoylphorbol Acetate	48-51	syndecan 4	Homo sapiens	124-134
12960172-9	2003	Interestingly, ALX overexpression strongly inhibited RE/AP activation in response to anti-CD28/phorbol 12-myristate 13-acetate (PMA) stimulation but had minimal effect when anti-TCR/PMA was used.	Tetradecanoylphorbol Acetate	95-126	hematopoietic SH2 domain containing	Homo sapiens	15-18
11994512-3	2002	Rather, Fas activation reduces the PMA-stimulated expression and aggregation of beta2 integrins responsible for endothelial adhesion.	Tetradecanoylphorbol Acetate	35-38	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	80-85
11994512-5	2002	Western blot and immunofluorescence studies indicated that 1 h of Fas activation is required to reduce PMA-stimulated translocation of PKCdelta to the membrane and adhesion.	Tetradecanoylphorbol Acetate	103-106	protein kinase C delta	Homo sapiens	135-143
11994512-6	2002	Rottlerin, a PKCdelta inhibitor, also reduced PMA-induced PKCdelta translocation and adhesion.	Tetradecanoylphorbol Acetate	46-49	protein kinase C delta	Homo sapiens	13-21
11994512-6	2002	Rottlerin, a PKCdelta inhibitor, also reduced PMA-induced PKCdelta translocation and adhesion.	Tetradecanoylphorbol Acetate	46-49	protein kinase C delta	Homo sapiens	58-66
12479852-4	2003	Prolonged exposure to 8Br-cAMP increased the phorbol 12-myristate 13-acetate (TPA)-stimulated superoxide generation and CD14 expression that characterize the differentiation phenotype, which was blocked by MEK-1 inhibitor.	Tetradecanoylphorbol Acetate	45-76	CD14 molecule	Homo sapiens	120-124
12960172-9	2003	Interestingly, ALX overexpression strongly inhibited RE/AP activation in response to anti-CD28/phorbol 12-myristate 13-acetate (PMA) stimulation but had minimal effect when anti-TCR/PMA was used.	Tetradecanoylphorbol Acetate	128-131	hematopoietic SH2 domain containing	Homo sapiens	15-18
12920112-3	2003	Pre-treatment with 12-O-tetradecanoylphorbol-13-acetate (PMA) led to inhibition of TRAIL-induced apoptosis in HeLa cells, which was characterized by a reduction in phosphatidylserine (PS) externalization, decreased caspase-8 processing, and incomplete maturation and activation of caspase-3.	Tetradecanoylphorbol Acetate	19-55	caspase 8	Homo sapiens	215-224
12058964-4	2002	TPA stimulated MMP-1, -9 and TIMP-1 mRNA expression in both cell lines.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 19	Homo sapiens	15-24
12920112-3	2003	Pre-treatment with 12-O-tetradecanoylphorbol-13-acetate (PMA) led to inhibition of TRAIL-induced apoptosis in HeLa cells, which was characterized by a reduction in phosphatidylserine (PS) externalization, decreased caspase-8 processing, and incomplete maturation and activation of caspase-3.	Tetradecanoylphorbol Acetate	57-60	caspase 8	Homo sapiens	215-224
12479852-4	2003	Prolonged exposure to 8Br-cAMP increased the phorbol 12-myristate 13-acetate (TPA)-stimulated superoxide generation and CD14 expression that characterize the differentiation phenotype, which was blocked by MEK-1 inhibitor.	Tetradecanoylphorbol Acetate	78-81	CD14 molecule	Homo sapiens	120-124
14596936-2	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced PLD1 activation was suppressed by the introduction of PKCdelta as well as its kinase-negative mutant in MeWo cells, which contain PKCalpha but lack PKCbeta.	Tetradecanoylphorbol Acetate	0-36	protein kinase C delta	Homo sapiens	105-113
11909979-4	2002	The knockout of both MSK1 and MSK2 resulted in a 50% reduction in c-fos and junB gene transcription in response to anisomycin or UV-C radiation but only a small reduction in response to tetradecanoyl phorbol acetate or epidermal growth factor in fibroblasts.	Tetradecanoylphorbol Acetate	186-215	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	21-25
14596936-2	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced PLD1 activation was suppressed by the introduction of PKCdelta as well as its kinase-negative mutant in MeWo cells, which contain PKCalpha but lack PKCbeta.	Tetradecanoylphorbol Acetate	0-36	protein kinase C beta	Homo sapiens	199-206
12616721-3	2003	The DNA binding activity of AP-1 proteins to a concensus DNA regulatory binding element known as TRE (TPA Responsive Element) is used as an in vitro assay for AP-1 activity in the nucleus of skin cells.	Tetradecanoylphorbol Acetate	102-105	jun proto-oncogene	Mus musculus	28-32
14596936-2	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced PLD1 activation was suppressed by the introduction of PKCdelta as well as its kinase-negative mutant in MeWo cells, which contain PKCalpha but lack PKCbeta.	Tetradecanoylphorbol Acetate	38-41	protein kinase C delta	Homo sapiens	105-113
12616721-3	2003	The DNA binding activity of AP-1 proteins to a concensus DNA regulatory binding element known as TRE (TPA Responsive Element) is used as an in vitro assay for AP-1 activity in the nucleus of skin cells.	Tetradecanoylphorbol Acetate	102-105	jun proto-oncogene	Mus musculus	159-163
11960370-1	2002	Treatment of fibroblasts with the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), specifically inhibits fibroblast growth factor-2 (FGF-2) induced proliferation.	Tetradecanoylphorbol Acetate	49-86	fibroblast growth factor 2	Rattus norvegicus	116-142
14596936-2	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced PLD1 activation was suppressed by the introduction of PKCdelta as well as its kinase-negative mutant in MeWo cells, which contain PKCalpha but lack PKCbeta.	Tetradecanoylphorbol Acetate	38-41	protein kinase C beta	Homo sapiens	199-206
11960370-1	2002	Treatment of fibroblasts with the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), specifically inhibits fibroblast growth factor-2 (FGF-2) induced proliferation.	Tetradecanoylphorbol Acetate	49-86	fibroblast growth factor 2	Rattus norvegicus	144-149
11960370-1	2002	Treatment of fibroblasts with the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), specifically inhibits fibroblast growth factor-2 (FGF-2) induced proliferation.	Tetradecanoylphorbol Acetate	88-91	fibroblast growth factor 2	Rattus norvegicus	116-142
14596936-5	2003	In cells overexpressing PKCdelta in addition to PKCalpha and PLD1, TPA treatment increased the association of PKCdelta and PLD1, while it attenuated the association of PKCalpha and PLD1.	Tetradecanoylphorbol Acetate	67-70	protein kinase C delta	Homo sapiens	24-32
11960370-1	2002	Treatment of fibroblasts with the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), specifically inhibits fibroblast growth factor-2 (FGF-2) induced proliferation.	Tetradecanoylphorbol Acetate	88-91	fibroblast growth factor 2	Rattus norvegicus	144-149
12444985-0	2002	Activation of transcription of the human presenilin 1 gene by 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	62-98	presenilin 1	Homo sapiens	41-53
12444985-4	2002	To gain further insight into the regulation of the gene we have examined the regulation of PS1 by 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	98-134	presenilin 1	Homo sapiens	91-94
11960370-2	2002	TPA treatment has little or no effect on FGF receptor activation but specifically inhibits the activation of p38 MAPK but not other downstream signaling pathways implicated in cell proliferation.	Tetradecanoylphorbol Acetate	0-3	mitogen activated protein kinase 14	Rattus norvegicus	109-112
14596936-5	2003	In cells overexpressing PKCdelta in addition to PKCalpha and PLD1, TPA treatment increased the association of PKCdelta and PLD1, while it attenuated the association of PKCalpha and PLD1.	Tetradecanoylphorbol Acetate	67-70	protein kinase C delta	Homo sapiens	110-118
11960370-4	2002	The effect of TPA on both p38 MAPK activation and cell proliferation can be reversed by treatment with the PKC inhibitor Go6983.	Tetradecanoylphorbol Acetate	14-17	mitogen activated protein kinase 14	Rattus norvegicus	26-29
12444985-4	2002	To gain further insight into the regulation of the gene we have examined the regulation of PS1 by 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	136-139	presenilin 1	Homo sapiens	91-94
12444985-5	2002	SK-N-SH neuronal cells were treated with 0.2 micro m TPA for 30 min to 24 h and the level of expression of the endogenous PS1 gene was measured by Northern blot analysis.	Tetradecanoylphorbol Acetate	53-56	presenilin 1	Homo sapiens	122-125
11960370-5	2002	The TPA-mediated inhibition of p38 MAPK activation requires phosphatase activity and is at least partially mediated by ERKs since it is reduced by treatment with the MEK inhibitor PD98059.	Tetradecanoylphorbol Acetate	4-7	mitogen activated protein kinase 14	Rattus norvegicus	31-34
14596936-6	2003	These results indicate that PKCdelta inhibits TPA-induced PLD1 activation mediated by PKCalpha through the association with PLD1.	Tetradecanoylphorbol Acetate	46-49	protein kinase C delta	Homo sapiens	28-36
11914583-1	2002	The functional role of mitogen-activated protein kinase (MAPK) signaling and c-Jun induction in phorbol 12-myristate 13-acetate (PMA)-induced human 12(S)-lipoxygenase gene expression was studied in human epidermoid carcinoma A431 cells.	Tetradecanoylphorbol Acetate	96-127	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	148-166
11914583-1	2002	The functional role of mitogen-activated protein kinase (MAPK) signaling and c-Jun induction in phorbol 12-myristate 13-acetate (PMA)-induced human 12(S)-lipoxygenase gene expression was studied in human epidermoid carcinoma A431 cells.	Tetradecanoylphorbol Acetate	129-132	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	148-166
11914583-3	2002	Treatment of cells with PD98059, which is an inhibitor of mitogen-activated protein kinase kinase (MEK), decreased the PMA-induced expression of 12(S)-lipoxygenase.	Tetradecanoylphorbol Acetate	119-122	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	145-163
12444985-6	2002	A two- to threefold increase in the level of PS1 mRNA appeared 4-8 h after the addition of TPA.	Tetradecanoylphorbol Acetate	91-94	presenilin 1	Homo sapiens	45-48
12444985-8	2002	Consistently, TPA also increased the level of PS1 protein.	Tetradecanoylphorbol Acetate	14-17	presenilin 1	Homo sapiens	46-49
12444985-10	2002	Next we tested the effect of TPA on the expression of the PS1 promoter by transfecting fusion genes including various fragments of the PS1 promoter linked to a CAT reporter into SK-N-SH cells.	Tetradecanoylphorbol Acetate	29-32	presenilin 1	Homo sapiens	58-61
12919959-5	2003	Concomitantly, TPA markedly stimulates early and persistent OPN expression and secretion for at least 4 days (the time required for these cells to begin to acquire the transformed phenotype) and increases cells" adhesion to OPN.	Tetradecanoylphorbol Acetate	15-18	secreted phosphoprotein 1	Mus musculus	60-63
12444985-14	2002	Thus TPA appears to activate the transcription of the PS1 gene by a mechanism which does not require these elements.	Tetradecanoylphorbol Acetate	5-8	presenilin 1	Homo sapiens	54-57
11893774-8	2002	The AP-1 activator, phorbol 12-myristate 13-acetate, inhibited the HL promoter by greater than 50%.	Tetradecanoylphorbol Acetate	20-51	lipase C, hepatic type	Homo sapiens	67-69
12919959-5	2003	Concomitantly, TPA markedly stimulates early and persistent OPN expression and secretion for at least 4 days (the time required for these cells to begin to acquire the transformed phenotype) and increases cells" adhesion to OPN.	Tetradecanoylphorbol Acetate	15-18	secreted phosphoprotein 1	Mus musculus	224-227
12472895-2	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced neurite outgrowth and growth cone formation, effects that were blocked by GF 109203X (a PKC inhibitor), safingolTM(a PKCalpha-selective inhibitor), but not by rottlerinTM (a PKCdelta-selective inhibitor), indicating that PKCalpha may be selectively involved in neurite outgrowth and cytoskeletal changes of filamentous actin and beta-tubulin.	Tetradecanoylphorbol Acetate	0-36	protein kinase C delta	Homo sapiens	225-233
11751871-3	2002	Further analysis demonstrated that serum or 12-O-tetradecanoylphorbol-13-acetate activation of several immediate early genes including fos, fosB, junB, and egr1 was inhibited by Wnt signaling.	Tetradecanoylphorbol Acetate	44-80	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-144
12472895-2	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced neurite outgrowth and growth cone formation, effects that were blocked by GF 109203X (a PKC inhibitor), safingolTM(a PKCalpha-selective inhibitor), but not by rottlerinTM (a PKCdelta-selective inhibitor), indicating that PKCalpha may be selectively involved in neurite outgrowth and cytoskeletal changes of filamentous actin and beta-tubulin.	Tetradecanoylphorbol Acetate	38-41	protein kinase C delta	Homo sapiens	225-233
12919959-6	2003	Here, we demonstrated that dexamethasone, a synthetic analog of glucocorticoid, known to inhibit tumor promotion in vivo, not only suppressed TPA-induced OPN mRNA expression and inhibited tumorigenic transformation of JB6 Cl41.5a cells (as previously shown in JB6 Cl22 and Cl41 cells), but also that the addition of OPN partially restored dexamethasone suppression of TPA-induced cell transformation.	Tetradecanoylphorbol Acetate	142-145	secreted phosphoprotein 1	Mus musculus	154-157
12472895-4	2002	TPA treatment induced relocalization of PKCalpha-EGFP to growth cones and cell-cell adhesion sites, PKCgamma-EGFP to the nucleus, and PKCdelta-EGFP to the membrane ruffle, respectively.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	134-142
11850819-9	2002	Specific inhibition of JNK by expression of the JNK Inhibitory Protein (JIP) dramatically inhibited both TPA- and TG-induced apoptosis.	Tetradecanoylphorbol Acetate	105-108	SMAD family member 4	Homo sapiens	48-70
12919959-9	2003	Furthermore, antisense OPN expressing JB6 clones suppressed TPA-induced OPN synthesis and secretion and inhibited TPA-induced anchorage-independent growth, which was partially rescued by the addition of OPN.	Tetradecanoylphorbol Acetate	60-63	secreted phosphoprotein 1	Mus musculus	23-26
11850819-9	2002	Specific inhibition of JNK by expression of the JNK Inhibitory Protein (JIP) dramatically inhibited both TPA- and TG-induced apoptosis.	Tetradecanoylphorbol Acetate	105-108	SMAD family member 4	Homo sapiens	72-75
12359735-5	2002	Moreover, the NO-induced degradation is reversed by the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), and also by the physiological PKC activators platelet-derived growth factor-BB (PDGF), angiotensin II and ATP, resulting in a normalization of neutral ceramidase protein as well as activity.	Tetradecanoylphorbol Acetate	90-126	N-acylsphingosine amidohydrolase 2	Rattus norvegicus	277-295
12359735-5	2002	Moreover, the NO-induced degradation is reversed by the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), and also by the physiological PKC activators platelet-derived growth factor-BB (PDGF), angiotensin II and ATP, resulting in a normalization of neutral ceramidase protein as well as activity.	Tetradecanoylphorbol Acetate	128-131	N-acylsphingosine amidohydrolase 2	Rattus norvegicus	277-295
12919959-9	2003	Furthermore, antisense OPN expressing JB6 clones suppressed TPA-induced OPN synthesis and secretion and inhibited TPA-induced anchorage-independent growth, which was partially rescued by the addition of OPN.	Tetradecanoylphorbol Acetate	60-63	secreted phosphoprotein 1	Mus musculus	72-75
11795874-6	2002	Overexpression of PKCepsilon, but not PKCdelta, was found to potentiate PMA-induced growth inhibition.	Tetradecanoylphorbol Acetate	72-75	protein kinase C, epsilon	Mus musculus	18-28
12919959-9	2003	Furthermore, antisense OPN expressing JB6 clones suppressed TPA-induced OPN synthesis and secretion and inhibited TPA-induced anchorage-independent growth, which was partially rescued by the addition of OPN.	Tetradecanoylphorbol Acetate	60-63	secreted phosphoprotein 1	Mus musculus	72-75
12244094-3	2002	Maximal binding of the Raf kinase domain to MEK1 and its kinase activity are achieved upon phosphorylation of the region (338)SSYY(341) in response to 4beta-12-O-tetradecanoylphorbol-13-acetate (TPA), or mutation of Y340Y341 to aspartic acids.	Tetradecanoylphorbol Acetate	195-198	zinc fingers and homeoboxes 2	Homo sapiens	23-26
12919959-9	2003	Furthermore, antisense OPN expressing JB6 clones suppressed TPA-induced OPN synthesis and secretion and inhibited TPA-induced anchorage-independent growth, which was partially rescued by the addition of OPN.	Tetradecanoylphorbol Acetate	114-117	secreted phosphoprotein 1	Mus musculus	23-26
14612503-6	2003	In addition, apoptosis mediated by combined DHT/TPA treatment was abrogated by overexpression of the NFkappaB subunit p65 in LNCaP-p65 cells, suggesting that NFkappaB may play an important role in regulating the effects of androgen/AR and TPA on apoptosis.	Tetradecanoylphorbol Acetate	48-51	RELA proto-oncogene, NF-kB subunit	Homo sapiens	118-121
11738249-5	2002	Consistent with the porcine data, pretreatment with PACAP or with phorbol ester [phorbol myristate acetate (PMA)] significantly suppressed NIC-induced intracellular Ca(2+) transients and catecholamine secretion in rat chromaffin cells.	Tetradecanoylphorbol Acetate	81-106	adenylate cyclase activating polypeptide 1	Rattus norvegicus	52-57
11738249-5	2002	Consistent with the porcine data, pretreatment with PACAP or with phorbol ester [phorbol myristate acetate (PMA)] significantly suppressed NIC-induced intracellular Ca(2+) transients and catecholamine secretion in rat chromaffin cells.	Tetradecanoylphorbol Acetate	108-111	adenylate cyclase activating polypeptide 1	Rattus norvegicus	52-57
12415120-6	2002	We also show that treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA) can lead to an increase in transcription from the IP, and that Bet protein expression abrogates this effect.	Tetradecanoylphorbol Acetate	51-82	delta/notch like EGF repeat containing	Homo sapiens	152-155
12415120-6	2002	We also show that treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA) can lead to an increase in transcription from the IP, and that Bet protein expression abrogates this effect.	Tetradecanoylphorbol Acetate	84-87	delta/notch like EGF repeat containing	Homo sapiens	152-155
14612503-6	2003	In addition, apoptosis mediated by combined DHT/TPA treatment was abrogated by overexpression of the NFkappaB subunit p65 in LNCaP-p65 cells, suggesting that NFkappaB may play an important role in regulating the effects of androgen/AR and TPA on apoptosis.	Tetradecanoylphorbol Acetate	48-51	RELA proto-oncogene, NF-kB subunit	Homo sapiens	131-134
11779130-5	2002	We further show that phorbol myristate acetate, an activator of protein kinase C, activated the secretion of OPG.	Tetradecanoylphorbol Acetate	21-46	TNF receptor superfamily member 11b	Homo sapiens	109-112
14612503-6	2003	In addition, apoptosis mediated by combined DHT/TPA treatment was abrogated by overexpression of the NFkappaB subunit p65 in LNCaP-p65 cells, suggesting that NFkappaB may play an important role in regulating the effects of androgen/AR and TPA on apoptosis.	Tetradecanoylphorbol Acetate	239-242	RELA proto-oncogene, NF-kB subunit	Homo sapiens	118-121
11779130-7	2002	In addition, OPG promoter stably integrated into an osteoblast cell line was activated by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	90-115	TNF receptor superfamily member 11b	Homo sapiens	13-16
14724758-6	2003	Whereas the PKC activators phorbol-12-myristate-13-acetate (PMA) and sn-1,2-dioctanoyl glycerol (DOG) increased alpha-methyl glucose (AMG) uptake expressed by hSGLT1 alone as described earlier, PMA and DOG decreased AMG uptake mediated by hSGLT1 when hRS1 was co-expressed.	Tetradecanoylphorbol Acetate	27-58	retinoschisin 1	Homo sapiens	251-255
14724758-6	2003	Whereas the PKC activators phorbol-12-myristate-13-acetate (PMA) and sn-1,2-dioctanoyl glycerol (DOG) increased alpha-methyl glucose (AMG) uptake expressed by hSGLT1 alone as described earlier, PMA and DOG decreased AMG uptake mediated by hSGLT1 when hRS1 was co-expressed.	Tetradecanoylphorbol Acetate	60-63	retinoschisin 1	Homo sapiens	251-255
11779197-3	2002	Agents that activate Ca(2+)-dependent PKC [phorbol-12-myristate-13-acetate (PMA) and bryostatin 1] increased the level of ER cholesterol; inhibitors such as staurosporine and calphostin C decreased it.	Tetradecanoylphorbol Acetate	43-74	protein kinase C delta	Homo sapiens	38-41
14564357-12	2003	The AID gene expression in the patient was induced by phorbol myristate acetate and TGF-beta.	Tetradecanoylphorbol Acetate	54-79	activation induced cytidine deaminase	Homo sapiens	4-7
11779197-3	2002	Agents that activate Ca(2+)-dependent PKC [phorbol-12-myristate-13-acetate (PMA) and bryostatin 1] increased the level of ER cholesterol; inhibitors such as staurosporine and calphostin C decreased it.	Tetradecanoylphorbol Acetate	76-79	protein kinase C delta	Homo sapiens	38-41
12377207-5	2002	VEGF-induced Akt activation was prevented by down-regulation of PKC induced by prolonged pretreatment with the phorbol ester, PMA.	Tetradecanoylphorbol Acetate	126-129	protein kinase C delta	Homo sapiens	64-67
12960243-4	2003	Immunoprecipitation experiments using plasma membranes of phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils revealed coimmunoprecipitation of PR3 with CD11b/CD18, indicating their location in the same complex.	Tetradecanoylphorbol Acetate	58-89	proteinase 3	Homo sapiens	153-156
12244571-8	2002	Moreover, the RGPR-p117 mRNA expression in H4-II-E cells was stimulated in the presence of dibutyryl cAMP, PMA, insulin, 17beta-estradiol, or serum in culture medium.	Tetradecanoylphorbol Acetate	107-110	SEC16 homolog B, endoplasmic reticulum export factor	Rattus norvegicus	14-23
12960243-4	2003	Immunoprecipitation experiments using plasma membranes of phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils revealed coimmunoprecipitation of PR3 with CD11b/CD18, indicating their location in the same complex.	Tetradecanoylphorbol Acetate	91-94	proteinase 3	Homo sapiens	153-156
14500826-4	2003	Here we show that the increase of protein level following PKC activation by phorbol ester (TPA) treatment parallels that of hMSH2 mRNA.	Tetradecanoylphorbol Acetate	91-94	mutS homolog 2	Homo sapiens	124-129
12090568-5	2002	GM-CSF receptor (GM-CSFR) was down-regulated by GM-CSF or phorbol 12-myristate 13-acetate in both of the normal controls and SLE patients, while this change was more remarkable in the latter.	Tetradecanoylphorbol Acetate	58-89	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	0-15
14500826-5	2003	Our results support the view that the hMSH2 gene is prone to transcriptional regulation upon TPA induction, and that AP-1 is a factor implicated in the transactivation.	Tetradecanoylphorbol Acetate	93-96	mutS homolog 2	Homo sapiens	38-43
12090568-5	2002	GM-CSF receptor (GM-CSFR) was down-regulated by GM-CSF or phorbol 12-myristate 13-acetate in both of the normal controls and SLE patients, while this change was more remarkable in the latter.	Tetradecanoylphorbol Acetate	58-89	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	17-25
14500826-6	2003	When losing the AP-1-dependent hMSH2 promoter activity, either by mutating the AP-1 binding sites of the hMSH2 promoter or by using a dominant negative c-Jun factor, the hMSH2 overexpression induced by TPA is abolished both in vitro and in vivo.	Tetradecanoylphorbol Acetate	202-205	mutS homolog 2	Homo sapiens	31-36
12090568-6	2002	In the presence of 1-(5-isoquinolinsulfonyl)-2-methylpiperazine, an inhibitor of protein kinase C, the PMA-induced down-regulation of GM-CSFR was reversed in the normal controls but not in SLE.	Tetradecanoylphorbol Acetate	103-106	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	134-141
14500826-6	2003	When losing the AP-1-dependent hMSH2 promoter activity, either by mutating the AP-1 binding sites of the hMSH2 promoter or by using a dominant negative c-Jun factor, the hMSH2 overexpression induced by TPA is abolished both in vitro and in vivo.	Tetradecanoylphorbol Acetate	202-205	mutS homolog 2	Homo sapiens	105-110
14500826-6	2003	When losing the AP-1-dependent hMSH2 promoter activity, either by mutating the AP-1 binding sites of the hMSH2 promoter or by using a dominant negative c-Jun factor, the hMSH2 overexpression induced by TPA is abolished both in vitro and in vivo.	Tetradecanoylphorbol Acetate	202-205	mutS homolog 2	Homo sapiens	105-110
12220559-5	2002	Activation of PKC with intracaudate injection of 12-O-tetradecanoylphorbol-13-acetate (TPA) mimicked DHPG actions in facilitating the phosphorylation of CREB, Elk-1, and ERK1/2.	Tetradecanoylphorbol Acetate	49-85	ETS transcription factor ELK1	Rattus norvegicus	159-164
12941843-5	2003	Furthermore, the incubation of HCT116 or RKO with phorbol myristate acetate for 16 h, which down-regulated the expression of novel PKC isoforms, also did not influence sensitivity to TRAIL either in the absence or presence of rottlerin.	Tetradecanoylphorbol Acetate	50-75	protein kinase C delta	Homo sapiens	131-134
12220559-5	2002	Activation of PKC with intracaudate injection of 12-O-tetradecanoylphorbol-13-acetate (TPA) mimicked DHPG actions in facilitating the phosphorylation of CREB, Elk-1, and ERK1/2.	Tetradecanoylphorbol Acetate	49-85	mitogen activated protein kinase 3	Rattus norvegicus	170-176
12220559-5	2002	Activation of PKC with intracaudate injection of 12-O-tetradecanoylphorbol-13-acetate (TPA) mimicked DHPG actions in facilitating the phosphorylation of CREB, Elk-1, and ERK1/2.	Tetradecanoylphorbol Acetate	87-90	ETS transcription factor ELK1	Rattus norvegicus	159-164
12220559-5	2002	Activation of PKC with intracaudate injection of 12-O-tetradecanoylphorbol-13-acetate (TPA) mimicked DHPG actions in facilitating the phosphorylation of CREB, Elk-1, and ERK1/2.	Tetradecanoylphorbol Acetate	87-90	mitogen activated protein kinase 3	Rattus norvegicus	170-176
12220559-6	2002	Blockade of N-methyl-D-aspartate (NMDA) glutamate receptors with the non-competitive antagonist MK801 or the competitive antagonist AP5 attenuated TPA-induced CREB, Elk-1, and ERK1/2 phosphorylation.	Tetradecanoylphorbol Acetate	147-150	mitogen activated protein kinase 3	Rattus norvegicus	176-182
12794177-8	2003	Both phorbol-12-myristate-13-acetate (PMA), which activates PKC and, in turn, ERK, and caffeine, which increases intracellular Ca2+ without eliciting contraction, increased HSL activity.	Tetradecanoylphorbol Acetate	5-36	lipase E, hormone sensitive type	Rattus norvegicus	173-176
12794177-8	2003	Both phorbol-12-myristate-13-acetate (PMA), which activates PKC and, in turn, ERK, and caffeine, which increases intracellular Ca2+ without eliciting contraction, increased HSL activity.	Tetradecanoylphorbol Acetate	38-41	lipase E, hormone sensitive type	Rattus norvegicus	173-176
12588704-11	2003	PMA activates cPKCalpha and nPKCdelta at high affinity and stimulates a lower affinity PKC-independent pathway that leads to mucin secretion.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, delta	Rattus norvegicus	15-18
12702734-7	2003	Western blot analysis demonstrated that both PMA treatment and incubation with the myristoylated PKCbetaC2-4 pseudosubstrate resulted in more glucose transporter (GLUT)-1 but not GLUT-4 at the plasma membrane.	Tetradecanoylphorbol Acetate	45-48	solute carrier family 2 member 4	Homo sapiens	179-185
12485900-5	2002	These ginsenosides also suppressed expression of cyclooxygenase-2 (COX-2) and activation of NF-kappaB in the TPA-treated dorsal skin of mice.	Tetradecanoylphorbol Acetate	109-112	prostaglandin-endoperoxide synthase 2	Mus musculus	49-65
12485900-5	2002	These ginsenosides also suppressed expression of cyclooxygenase-2 (COX-2) and activation of NF-kappaB in the TPA-treated dorsal skin of mice.	Tetradecanoylphorbol Acetate	109-112	prostaglandin-endoperoxide synthase 2	Mus musculus	67-72
12171923-9	2002	JDP2 potentiated and synergized with 12-O-tetradecanoylphorbol-13-acetate to induce muscle cell differentiation of RD cells.	Tetradecanoylphorbol Acetate	37-73	Jun dimerization protein 2	Mus musculus	0-4
12876631-2	2003	The recently described thrombin-activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis by cleaving of the C-terminal lysine residues from fibrin, thereby inhibiting tPA mediated plasminogen activation.	Tetradecanoylphorbol Acetate	176-179	carboxypeptidase B2	Homo sapiens	23-66
12372429-4	2002	E1 and E2 contain a phorbol 12-O-tetradecanoate-13-acetate (TPA)-responsive element (TRE) and TRE-like element, respectively.	Tetradecanoylphorbol Acetate	60-63	skull morphology 2	Mus musculus	0-8
12209884-3	2002	TPA-induced mitogen activated protein kinases (MAPK) phosphorylation, ornithine decarboxylase (ODC), c-Jun, and cyclooxygenase 2 (COX-2) protein expressions in a time-dependent manner, and the maximal inductive time point is at 1 h for MAPK phosphorylation and 6 h for others.	Tetradecanoylphorbol Acetate	0-3	jun proto-oncogene	Mus musculus	101-106
12209884-3	2002	TPA-induced mitogen activated protein kinases (MAPK) phosphorylation, ornithine decarboxylase (ODC), c-Jun, and cyclooxygenase 2 (COX-2) protein expressions in a time-dependent manner, and the maximal inductive time point is at 1 h for MAPK phosphorylation and 6 h for others.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	112-128
11679632-2	2001	After binding of its ligand heregulin (HRG) or activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA), the ErbB-4 ectodomain is cleaved by a metalloprotease.	Tetradecanoylphorbol Acetate	87-123	erb-b2 receptor tyrosine kinase 4	Homo sapiens	135-141
12876631-2	2003	The recently described thrombin-activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis by cleaving of the C-terminal lysine residues from fibrin, thereby inhibiting tPA mediated plasminogen activation.	Tetradecanoylphorbol Acetate	176-179	carboxypeptidase B2	Homo sapiens	68-72
12209884-3	2002	TPA-induced mitogen activated protein kinases (MAPK) phosphorylation, ornithine decarboxylase (ODC), c-Jun, and cyclooxygenase 2 (COX-2) protein expressions in a time-dependent manner, and the maximal inductive time point is at 1 h for MAPK phosphorylation and 6 h for others.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	130-135
12209884-4	2002	Flavanone, 2"-OH flavanone, 4"-OH flavanone, 6-OH flavanone showed the dose-dependent inhibition on TPA-stimulated MAPK phosphorylation, COX-2, ODC, c-Jun protein expressions.	Tetradecanoylphorbol Acetate	100-103	prostaglandin-endoperoxide synthase 2	Mus musculus	137-142
12788225-2	2003	Treatment with phorbol 12-myristate 13-acetate (PMA) increased significantly the level of expression of galectin-3 in THP-1 cells.	Tetradecanoylphorbol Acetate	15-46	galectin 3	Homo sapiens	104-114
12209884-4	2002	Flavanone, 2"-OH flavanone, 4"-OH flavanone, 6-OH flavanone showed the dose-dependent inhibition on TPA-stimulated MAPK phosphorylation, COX-2, ODC, c-Jun protein expressions.	Tetradecanoylphorbol Acetate	100-103	jun proto-oncogene	Mus musculus	149-154
12209884-7	2002	And, PD98059, a specific inhibitor of ERKs, inhibited TPA-induced MAPK phosphorylation, accompanied by decreasing COX-2, c-Jun, and ODC protein expression, and showed dose-dependent inhibition on TPA-induced proliferation in cells.	Tetradecanoylphorbol Acetate	54-57	prostaglandin-endoperoxide synthase 2	Mus musculus	114-119
12209884-7	2002	And, PD98059, a specific inhibitor of ERKs, inhibited TPA-induced MAPK phosphorylation, accompanied by decreasing COX-2, c-Jun, and ODC protein expression, and showed dose-dependent inhibition on TPA-induced proliferation in cells.	Tetradecanoylphorbol Acetate	54-57	jun proto-oncogene	Mus musculus	121-126
12209884-8	2002	These results demonstrated that PGE(2) is an important mediator in TPA-induced proliferation, and MAPK phosphorylation was located at the upstream of COX-2, c-Jun, and ODC gene expressions in TPA-induced responses.	Tetradecanoylphorbol Acetate	192-195	prostaglandin-endoperoxide synthase 2	Mus musculus	150-155
12209884-8	2002	These results demonstrated that PGE(2) is an important mediator in TPA-induced proliferation, and MAPK phosphorylation was located at the upstream of COX-2, c-Jun, and ODC gene expressions in TPA-induced responses.	Tetradecanoylphorbol Acetate	192-195	jun proto-oncogene	Mus musculus	157-162
12209884-9	2002	Furthermore, flavanone, 2"-OH flavanone, 4"-OH flavanone, 6-OH flavanone (100 microM) suppressed TPA-induced colony formation associated with blocking MAPK phosphorylation, ODC, c-Jun, and COX-2 proteins expression.	Tetradecanoylphorbol Acetate	97-100	jun proto-oncogene	Mus musculus	178-183
11701442-6	2001	Forskolin reduced the p38 MAP kinase phosphorylation induced by ET-1 or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	72-108	mitogen-activated protein kinase 14	Mus musculus	22-25
11701442-6	2001	Forskolin reduced the p38 MAP kinase phosphorylation induced by ET-1 or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	110-113	mitogen-activated protein kinase 14	Mus musculus	22-25
11701442-8	2001	In addition, the phosphorylation of p38 MAP kinase induced by ET-1 or TPA was suppressed by PGE(1).	Tetradecanoylphorbol Acetate	70-73	mitogen-activated protein kinase 14	Mus musculus	36-39
12209884-9	2002	Furthermore, flavanone, 2"-OH flavanone, 4"-OH flavanone, 6-OH flavanone (100 microM) suppressed TPA-induced colony formation associated with blocking MAPK phosphorylation, ODC, c-Jun, and COX-2 proteins expression.	Tetradecanoylphorbol Acetate	97-100	prostaglandin-endoperoxide synthase 2	Mus musculus	189-194
12788225-2	2003	Treatment with phorbol 12-myristate 13-acetate (PMA) increased significantly the level of expression of galectin-3 in THP-1 cells.	Tetradecanoylphorbol Acetate	48-51	galectin 3	Homo sapiens	104-114
11606483-10	2001	We suggest that a polymorphism of CRH-R1 expression is related to anatomic location, skin physiological or pathologic status, specific cell type, and external stress (UV), and that cAMP-dependent pathways and TPA may regulate CRH-R1.	Tetradecanoylphorbol Acetate	209-212	corticotropin releasing hormone receptor 1	Homo sapiens	34-40
12788225-3	2003	PMA-induced galectin-3 overexpression was blocked by: protein kinase C inhibitors staurosporine, calphostin C, and apigenin; tyrosine-specific protein kinase inhibitors genistein and tyrphostin A25; PD 98059, a selective inhibitor of mitogen-activated protein kinase (MAPK) kinase 1 (MEK1 or MKK1); and SB 203580, a specific inhibitor of p38 MAPK.	Tetradecanoylphorbol Acetate	0-3	galectin 3	Homo sapiens	12-22
11606483-10	2001	We suggest that a polymorphism of CRH-R1 expression is related to anatomic location, skin physiological or pathologic status, specific cell type, and external stress (UV), and that cAMP-dependent pathways and TPA may regulate CRH-R1.	Tetradecanoylphorbol Acetate	209-212	corticotropin releasing hormone receptor 1	Homo sapiens	226-232
11592942-6	2001	Complement and phorbol 12-myristate 13-acetate (PMA) both stimulated COX-2 promoter activity.	Tetradecanoylphorbol Acetate	15-46	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	69-74
11592942-6	2001	Complement and phorbol 12-myristate 13-acetate (PMA) both stimulated COX-2 promoter activity.	Tetradecanoylphorbol Acetate	48-51	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	69-74
12423237-2	2002	In primary murine astrocytes, phorbol myristate acetate (PMA) and ATP stimulated phosphorylation of ERK1/2 and cPLA2 as well as evoked AA release.	Tetradecanoylphorbol Acetate	30-55	mitogen-activated protein kinase 3	Mus musculus	100-106
12423237-2	2002	In primary murine astrocytes, phorbol myristate acetate (PMA) and ATP stimulated phosphorylation of ERK1/2 and cPLA2 as well as evoked AA release.	Tetradecanoylphorbol Acetate	30-55	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	111-116
12423237-2	2002	In primary murine astrocytes, phorbol myristate acetate (PMA) and ATP stimulated phosphorylation of ERK1/2 and cPLA2 as well as evoked AA release.	Tetradecanoylphorbol Acetate	57-60	mitogen-activated protein kinase 3	Mus musculus	100-106
12423237-2	2002	In primary murine astrocytes, phorbol myristate acetate (PMA) and ATP stimulated phosphorylation of ERK1/2 and cPLA2 as well as evoked AA release.	Tetradecanoylphorbol Acetate	57-60	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	111-116
12749866-8	2003	Furthermore, overexpression of PKC delta in HL-CR cells potentiated C2-ceramide- and TPA-induced apoptosis and growth inhibition.	Tetradecanoylphorbol Acetate	85-88	protein kinase C delta	Homo sapiens	31-40
11731334-2	2001	PMA/Ionomycin treatment caused significant time-dependent increases in mobile lipid and in oil red O-positive lipid droplets that were accompanied by lymphocyte proliferation and increases in activation antigens, CD25, CD69 and CD71.	Tetradecanoylphorbol Acetate	0-3	transferrin receptor	Homo sapiens	228-232
11591175-0	2001	p21(WAF1) is associated with CDK2 and CDK4 protein during HL-60 cell differentiation by TPA treatment.	Tetradecanoylphorbol Acetate	88-91	cyclin dependent kinase 2	Homo sapiens	29-33
12749866-9	2003	These results suggest a role for ceramide in apoptosis and differentiation in HL-60 cells, and also suggest that PKC delta might be involved in ceramide- and TPA-induced apoptosis.	Tetradecanoylphorbol Acetate	158-161	protein kinase C delta	Homo sapiens	113-122
11591175-0	2001	p21(WAF1) is associated with CDK2 and CDK4 protein during HL-60 cell differentiation by TPA treatment.	Tetradecanoylphorbol Acetate	88-91	cyclin dependent kinase 4	Homo sapiens	38-42
11591175-4	2001	pRb is dephosphorylated in the presence of p21-CDK2/4 complexes, and the Rb-E2F1 complex increases after TPA treatment, whereas the Rb-HDAC1 complex decreases slightly.	Tetradecanoylphorbol Acetate	105-108	RB transcriptional corepressor 1	Homo sapiens	0-3
12234954-4	2002	METHODS AND RESULTS: In whole-cell patch-clamp experiments with isolated human atrial cardiomyocytes, the IK1 was reduced by 41% when the nonspecific activator of PKC phorbol 12 myristate 13-acetate (PMA; 100 nmol/L) was applied.	Tetradecanoylphorbol Acetate	200-203	potassium calcium-activated channel subfamily N member 4	Homo sapiens	106-109
12773514-6	2003	Also, Lck and Fyn as well as MEK1/ERK and p38 MAPK were found to regulate MICA expression in anti-CD28/phorbol 12-myristate 13-acetate-stimulated T cells.	Tetradecanoylphorbol Acetate	103-134	MHC class I polypeptide-related sequence A	Homo sapiens	74-78
12048182-5	2002	Phorbol 12-myristate 13-acetate, a differentiation-inducing stimulus, potently activates the Ras-Raf-MEK-ERK pathway but only weakly activates PI3K/Akt and does not trigger the cross-talk.	Tetradecanoylphorbol Acetate	0-31	zinc fingers and homeoboxes 2	Homo sapiens	97-100
11557296-10	2001	In contrast, PMA-induced activation of beta 2 integrin-dependent adhesion and respiratory burst activity are wortmannin and LY294002 insensitive.	Tetradecanoylphorbol Acetate	13-16	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	39-45
12773514-6	2003	Also, Lck and Fyn as well as MEK1/ERK and p38 MAPK were found to regulate MICA expression in anti-CD28/phorbol 12-myristate 13-acetate-stimulated T cells.	Tetradecanoylphorbol Acetate	103-134	CD28 molecule	Homo sapiens	98-102
12187329-9	2002	Expression of the beta(2)-integrin CD11c that is induced during TPA-mediated differentiation remained unaltered after exposure to SC-10 and was partly reduced after treatment with FTT.	Tetradecanoylphorbol Acetate	64-67	integrin subunit alpha X	Homo sapiens	35-40
12214859-4	2002	In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kappaB through inhibition of IkappaB alpha degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells.	Tetradecanoylphorbol Acetate	61-64	RELA proto-oncogene, NF-kB subunit	Homo sapiens	200-203
11432850-4	2001	Phorbol 12-myristate 13-acetate, guanosine 5"-3-O- (thio)triphosphate (GTP gamma S), or FMLP stimulated a similar diphenylene iodonium-sensitive diaphorase activity pattern in neutrophils and in differentiated parent PLB-985 cells.	Tetradecanoylphorbol Acetate	0-31	dihydrolipoamide dehydrogenase	Homo sapiens	145-155
12646577-17	2003	Incadronate markedly enhanced the phosphorylation of Raf-1, MEK1/2, and p44/p42 MAPK induced by PGF2 alpha or 12-O-tetradecanoylphorbol-13-acetate, a PKC activator.	Tetradecanoylphorbol Acetate	110-146	mitogen-activated protein kinase kinase 1	Mus musculus	60-66
12646577-17	2003	Incadronate markedly enhanced the phosphorylation of Raf-1, MEK1/2, and p44/p42 MAPK induced by PGF2 alpha or 12-O-tetradecanoylphorbol-13-acetate, a PKC activator.	Tetradecanoylphorbol Acetate	110-146	mitogen-activated protein kinase 3	Mus musculus	72-75
11477572-14	2001	TPA-induced ODC activity and the resultant accumulation of polyamines may play different roles (e.g., induction of apoptosis vs. proliferation) in the pathways leading to the induction of cancer in PKC alpha, PKC delta and PKC epsilon transgenic mice.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, epsilon	Mus musculus	223-234
12522006-1	2003	Monocytic differentiation of 32DPKCdelta cells in response to activation of protein kinase C delta (PKCdelta) by phorbol 12-myristate 13-acetate (PMA) was inhibited by exogenous CCAAT/enhancer binding protein alpha-estradiol receptor (C/EBPalpha-ER), which impeded morphologic maturation and induction of macrosialin mRNA.	Tetradecanoylphorbol Acetate	146-149	protein kinase C delta	Homo sapiens	32-40
12801911-6	2003	Also, nuclear translocation of ERK induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by SB 239063, which does not associate with c-Raf and is highly selective for p38 MAP kinase.	Tetradecanoylphorbol Acetate	46-83	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	148-153
11692164-11	2001	Also, neither simultaneous nor Ang II pre-stimulation, suggested to induce gene expression of the MAP kinase phosphatase 1, modulated phorbol myristate acetate-stimulated ERK1/ERK2 activation in AT2R-transduced pFib, in AT2R-transduced human umbilical vein endothelial cells, and in PC12W cells.	Tetradecanoylphorbol Acetate	134-159	angiotensin II receptor, type 2	Rattus norvegicus	195-199
12801911-6	2003	Also, nuclear translocation of ERK induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was inhibited by SB 239063, which does not associate with c-Raf and is highly selective for p38 MAP kinase.	Tetradecanoylphorbol Acetate	85-88	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	148-153
12694376-5	2003	Both wound-healing and Boyden migration assays showed that TPA treatment promoted neuronal migration of GT1 cells; however, cotreatment of TPA with safingol or rottlerin (a PKC delta-selective inhibitor) clearly blocked this TPA effect, indicating that both PKC alpha and PKC delta may be positive regulators of neuronal migration.	Tetradecanoylphorbol Acetate	59-62	protein kinase C delta	Homo sapiens	272-281
11578113-6	2001	Western-blot analysis revealed that the induction of COX-2 protein by TPA was inhibited by compound 9 in parallel with the inhibition of PGE2 production.	Tetradecanoylphorbol Acetate	70-73	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	53-58
11485567-4	2001	Here we provide evidence that PMA-induced IL-6Ralpha shedding is controlled by a metalloproteinase and by protein kinase C (PKC) isoenzymes that do not require Ca(2+) for their activation.	Tetradecanoylphorbol Acetate	30-33	protein kinase C delta	Homo sapiens	124-127
12694376-5	2003	Both wound-healing and Boyden migration assays showed that TPA treatment promoted neuronal migration of GT1 cells; however, cotreatment of TPA with safingol or rottlerin (a PKC delta-selective inhibitor) clearly blocked this TPA effect, indicating that both PKC alpha and PKC delta may be positive regulators of neuronal migration.	Tetradecanoylphorbol Acetate	139-142	protein kinase C delta	Homo sapiens	173-182
11485567-7	2001	Treatment with PMA induces an increase in PKC-delta phosphorylation in its active loop.	Tetradecanoylphorbol Acetate	15-18	protein kinase C delta	Homo sapiens	42-51
12694376-5	2003	Both wound-healing and Boyden migration assays showed that TPA treatment promoted neuronal migration of GT1 cells; however, cotreatment of TPA with safingol or rottlerin (a PKC delta-selective inhibitor) clearly blocked this TPA effect, indicating that both PKC alpha and PKC delta may be positive regulators of neuronal migration.	Tetradecanoylphorbol Acetate	139-142	protein kinase C delta	Homo sapiens	272-281
11485567-8	2001	In addition, by using rottlerin, a specific inhibitor of PKC-delta, we demonstrate that PKC-delta is involved in the PMA-induced shedding of IL-6Ralpha.	Tetradecanoylphorbol Acetate	117-120	protein kinase C delta	Homo sapiens	57-66
11485567-8	2001	In addition, by using rottlerin, a specific inhibitor of PKC-delta, we demonstrate that PKC-delta is involved in the PMA-induced shedding of IL-6Ralpha.	Tetradecanoylphorbol Acetate	117-120	protein kinase C delta	Homo sapiens	88-97
12748306-11	2003	cV1q also reduced TPA-stimulated expression of matrix metalloproteinase 9 and granulocyte macrophage colony-stimulating factor, proteins that are differentially regulated in wt and TNF-alpha(-/-) epidermis.	Tetradecanoylphorbol Acetate	18-21	matrix metallopeptidase 9	Mus musculus	47-73
11485567-11	2001	Taken together, these results suggest that the PMA-induced shedding of IL-6Ralpha is mediated by a PKC isoenzyme network.	Tetradecanoylphorbol Acetate	47-50	protein kinase C delta	Homo sapiens	99-102
12684620-6	2003	Furthermore, sericin treatment significantly suppressed the elevation in 4-HNE level and elevated expressions of c-fos, c-myc and cyclooxygenase-2 (COX-2) in normal epidermis induced by double application of TPA.	Tetradecanoylphorbol Acetate	208-211	prostaglandin-endoperoxide synthase 2	Mus musculus	148-153
11358964-5	2001	Down-regulation of PKC epsilon protein levels by antisense oligodeoxyribonucleotides blocks MAPK activation in response to PMA stimulation, demonstrating that PKC epsilon activity is required for MAPK activation by PMA.	Tetradecanoylphorbol Acetate	123-126	protein kinase C, epsilon	Mus musculus	19-30
11358964-5	2001	Down-regulation of PKC epsilon protein levels by antisense oligodeoxyribonucleotides blocks MAPK activation in response to PMA stimulation, demonstrating that PKC epsilon activity is required for MAPK activation by PMA.	Tetradecanoylphorbol Acetate	123-126	protein kinase C, epsilon	Mus musculus	159-170
12647303-12	2003	Treatment with phorbol 12-myristate-13-acetate (PMA), under conditions that caused downregulation of protein kinase Calpha (PKCalpha), decreased nuclear FGF-2.	Tetradecanoylphorbol Acetate	15-46	fibroblast growth factor 2	Cricetulus griseus	153-158
12647303-12	2003	Treatment with phorbol 12-myristate-13-acetate (PMA), under conditions that caused downregulation of protein kinase Calpha (PKCalpha), decreased nuclear FGF-2.	Tetradecanoylphorbol Acetate	48-51	fibroblast growth factor 2	Cricetulus griseus	153-158
11454555-7	2001	Exposure to the phorbol ester phorbol 12-myristate 13-acetate (PMA; 50 ng/ml) resulted in a 30% increase in zymographic gelatinase activity and a 63% increase in MMP-2 content (P &lt; 0.05), suggesting that protein kinase C activation may be an intracellular mechanism for MMP induction.	Tetradecanoylphorbol Acetate	30-61	matrix metallopeptidase 2	Homo sapiens	162-167
12551925-4	2003	RKIP Ser-153 phosphorylation by PKC either in vitro or in response to 12-O-tetradecanoylphorbol-13-acetate or epidermal growth factor causes release of RKIP from Raf-1, whereas mutant RKIP (S153V or S153E) remains bound.	Tetradecanoylphorbol Acetate	70-106	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	162-167
11454555-7	2001	Exposure to the phorbol ester phorbol 12-myristate 13-acetate (PMA; 50 ng/ml) resulted in a 30% increase in zymographic gelatinase activity and a 63% increase in MMP-2 content (P &lt; 0.05), suggesting that protein kinase C activation may be an intracellular mechanism for MMP induction.	Tetradecanoylphorbol Acetate	63-66	matrix metallopeptidase 2	Homo sapiens	162-167
11509337-7	2001	We found that after a 24-h incubation with GM-CSF, AP-1 DNA binding was significantly increased in both unstimulated, interleukin (IL)-13, and phorbol myristate acetate (PMA)-stimulated alveolar macrophages and that there was a corresponding increase in Ref-1 protein by Western blot analysis in the PMA-stimulated group.	Tetradecanoylphorbol Acetate	143-168	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	254-259
12670703-1	2003	Several treatments which regulate tyrosine hydroxylase (TH) transcription, such as stress in vivo, or 12-O-tetradecanoylphorbol-13-acetate (TPA) in cell culture, induce both Egr1 and AP1 factors.	Tetradecanoylphorbol Acetate	102-138	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	183-186
11509337-7	2001	We found that after a 24-h incubation with GM-CSF, AP-1 DNA binding was significantly increased in both unstimulated, interleukin (IL)-13, and phorbol myristate acetate (PMA)-stimulated alveolar macrophages and that there was a corresponding increase in Ref-1 protein by Western blot analysis in the PMA-stimulated group.	Tetradecanoylphorbol Acetate	170-173	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	254-259
11529866-5	2001	In addition, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, stimulated a marked loss of cell surface syndecan-1 from each of the cell lines and this was associated with a corresponding increase in soluble syndecan-1.	Tetradecanoylphorbol Acetate	13-44	syndecan 1	Homo sapiens	127-137
12670703-1	2003	Several treatments which regulate tyrosine hydroxylase (TH) transcription, such as stress in vivo, or 12-O-tetradecanoylphorbol-13-acetate (TPA) in cell culture, induce both Egr1 and AP1 factors.	Tetradecanoylphorbol Acetate	140-143	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	183-186
11529866-5	2001	In addition, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, stimulated a marked loss of cell surface syndecan-1 from each of the cell lines and this was associated with a corresponding increase in soluble syndecan-1.	Tetradecanoylphorbol Acetate	13-44	syndecan 1	Homo sapiens	231-241
12670703-6	2003	Electrophoretic mobility shift assays with nuclear extracts from TPA treated cells were used to identify the composition of the factors which bound the AP1/Ebox motif and whether there is competition with factors which bind the Sp1/Egr1 motif.	Tetradecanoylphorbol Acetate	65-68	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	152-155
11529866-5	2001	In addition, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, stimulated a marked loss of cell surface syndecan-1 from each of the cell lines and this was associated with a corresponding increase in soluble syndecan-1.	Tetradecanoylphorbol Acetate	46-49	syndecan 1	Homo sapiens	127-137
11529866-5	2001	In addition, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, stimulated a marked loss of cell surface syndecan-1 from each of the cell lines and this was associated with a corresponding increase in soluble syndecan-1.	Tetradecanoylphorbol Acetate	46-49	syndecan 1	Homo sapiens	231-241
11526432-2	2001	The present studies demonstrate that TPA targets SAPK to mitochondria by a mechanism dependent on activation of protein kinase C (PKC) beta.	Tetradecanoylphorbol Acetate	37-40	protein kinase C beta	Homo sapiens	112-139
12670703-9	2003	Fra-2 was a major component of the complex after 2-4 h TPA.	Tetradecanoylphorbol Acetate	55-58	FOS like 2, AP-1 transcription factor subunit	Rattus norvegicus	0-5
12616538-4	2003	Here we demonstrate that PECAM-1 expression is dramatically up regulated upon phorbol myristate acetate (PMA) or transforming growth factor (TGF)-beta1-mediated differentiation of leukemic HEL and U937 cells.	Tetradecanoylphorbol Acetate	78-103	platelet and endothelial cell adhesion molecule 1	Homo sapiens	25-32
11476900-4	2001	Here we report that DP cells that were treated with PMA and ionomycin up-regulated bcl-2 and down-regulated CD1 expression.	Tetradecanoylphorbol Acetate	52-55	CD1c molecule	Homo sapiens	108-111
11466413-3	2001	The formation of PICK1-PKCalpha complexes is strongly induced by TPA, and PICK1-PKCalpha complexes are cotargeted with PICK1-GluR2 complexes to spines, where GluR2 is found to be phosphorylated by PKC on serine 880.	Tetradecanoylphorbol Acetate	65-68	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	125-130
12616538-4	2003	Here we demonstrate that PECAM-1 expression is dramatically up regulated upon phorbol myristate acetate (PMA) or transforming growth factor (TGF)-beta1-mediated differentiation of leukemic HEL and U937 cells.	Tetradecanoylphorbol Acetate	105-108	platelet and endothelial cell adhesion molecule 1	Homo sapiens	25-32
11466413-3	2001	The formation of PICK1-PKCalpha complexes is strongly induced by TPA, and PICK1-PKCalpha complexes are cotargeted with PICK1-GluR2 complexes to spines, where GluR2 is found to be phosphorylated by PKC on serine 880.	Tetradecanoylphorbol Acetate	65-68	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	158-163
12646629-4	2003	A suboptimal concentration of ionomycin in the presence of PMA fully activates Tgfb1(-/-) thymocytes, whereas the inhibitors of Ca(2+) influx and calcineurin, EGTA and FK506, eliminate the hyperresponsiveness.	Tetradecanoylphorbol Acetate	59-62	transforming growth factor, beta 1	Mus musculus	79-84
11462044-6	2001	Moreover, the ORF59 protein, a DNA replication-associated protein of HHV-8, was expressed in such HUVECs in the presence of TPA stimulation.	Tetradecanoylphorbol Acetate	124-127	ORF59	Human gammaherpesvirus 8	14-19
12629514-6	2003	Furthermore, we showed that PS1 is redistributed to ruffling areas of the plasma membrane similarly to CD44 after TPA treatment, supporting our biochemical observation that PS1 is involved in the intramembranous cleavage of CD44.	Tetradecanoylphorbol Acetate	114-117	presenilin 1	Homo sapiens	173-176
11309389-8	2001	The GH concentration dependence for inhibition of PMA-induced GHR proteolysis paralleled that for its promotion of receptor dimerization (as monitored by formation of GHR disulfide linkage).	Tetradecanoylphorbol Acetate	50-53	growth hormone receptor	Oryctolagus cuniculus	62-65
11309389-8	2001	The GH concentration dependence for inhibition of PMA-induced GHR proteolysis paralleled that for its promotion of receptor dimerization (as monitored by formation of GHR disulfide linkage).	Tetradecanoylphorbol Acetate	50-53	growth hormone receptor	Oryctolagus cuniculus	167-170
11309389-10	2001	Our data suggest that GH inhibits PMA-induced GHR proteolysis and GHBP shedding by inducing GHR dimerization and that this effect does not appear to be related to GH site 1 binding, GHR internalization, or GHR signaling.	Tetradecanoylphorbol Acetate	34-37	growth hormone receptor	Oryctolagus cuniculus	46-49
11309389-10	2001	Our data suggest that GH inhibits PMA-induced GHR proteolysis and GHBP shedding by inducing GHR dimerization and that this effect does not appear to be related to GH site 1 binding, GHR internalization, or GHR signaling.	Tetradecanoylphorbol Acetate	34-37	growth hormone receptor	Oryctolagus cuniculus	92-95
12663516-5	2003	Benign papillomas that arose on the skin of CkMGMT transgenic mice upon initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) expressed higher levels of MGMT than papillomas that appeared on DMBA/TPA treated non-transgenic NMRI mice.	Tetradecanoylphorbol Acetate	143-179	O-6-methylguanine-DNA methyltransferase	Mus musculus	46-50
11309389-10	2001	Our data suggest that GH inhibits PMA-induced GHR proteolysis and GHBP shedding by inducing GHR dimerization and that this effect does not appear to be related to GH site 1 binding, GHR internalization, or GHR signaling.	Tetradecanoylphorbol Acetate	34-37	growth hormone receptor	Oryctolagus cuniculus	92-95
11309389-10	2001	Our data suggest that GH inhibits PMA-induced GHR proteolysis and GHBP shedding by inducing GHR dimerization and that this effect does not appear to be related to GH site 1 binding, GHR internalization, or GHR signaling.	Tetradecanoylphorbol Acetate	34-37	growth hormone receptor	Oryctolagus cuniculus	92-95
11500965-3	2001	Since PKC can activate extracellular signal regulated kinases (ERKs) and these also downregulate GJIC, we hypothesized that the inhibition of GJIC by TPA involved ERKs.	Tetradecanoylphorbol Acetate	150-153	mitogen activated protein kinase 3	Rattus norvegicus	63-67
11500965-3	2001	Since PKC can activate extracellular signal regulated kinases (ERKs) and these also downregulate GJIC, we hypothesized that the inhibition of GJIC by TPA involved ERKs.	Tetradecanoylphorbol Acetate	150-153	mitogen activated protein kinase 3	Rattus norvegicus	163-167
12536201-7	2003	RNAi for c-raf gene blocked the appearance of the monocytic differentiation induced by treatment with TPA.	Tetradecanoylphorbol Acetate	102-105	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	9-14
11500965-4	2001	TPA treatment (10 ng/ml for 30 min) of WB-F344 rat liver epithelial cells strongly activated p42 and p44 ERK-1 and -2, blocked gap junction-mediated fluorescent dye-coupling, and induced connexin43 hyperphosphorylation and gap junction internalization.	Tetradecanoylphorbol Acetate	0-3	mitogen activated protein kinase 3	Rattus norvegicus	101-117
11500965-6	2001	These data suggest that ERKs are activated by PKC in response to TPA treatment and are downstream mediators of the gap junction effects of the phorbol ester.	Tetradecanoylphorbol Acetate	65-68	mitogen activated protein kinase 3	Rattus norvegicus	24-28
12566297-8	2003	Again, DMBA/PMA-induced tumor formation was less (71% versus 89%) and significantly delayed (P = 0.02) in K14-survivin p53+/- animals compared with p53+/- non-Tgs.	Tetradecanoylphorbol Acetate	12-15	baculoviral IAP repeat-containing 5	Mus musculus	110-118
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	54-85	involucrin	Mus musculus	186-196
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	54-85	involucrin	Mus musculus	186-189
12020766-4	2002	Phosphorylation of ERK1/2 was mimicked by the protein kinase C (PKC) activator phorbol 12-myristate acetate (PMA), but was not altered either by PKC inhibitor GF109203X or by down-regulation of PKC.	Tetradecanoylphorbol Acetate	109-112	mitogen activated protein kinase 3	Rattus norvegicus	19-25
12138138-7	2002	Phorbol-12-myristate-13-acetate (3 to 60 ng/ml) increased MMP-9 expression in both MC types (3- to 4.5-fold), but the level in ROP MC never reached that in B6SLJ MC.	Tetradecanoylphorbol Acetate	0-31	matrix metallopeptidase 9	Mus musculus	58-63
12526024-8	2003	Basal expression of SNAP-25 was also modified by the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate, but not by Go6976, a PKC-alpha inhibitor, suggesting that the Ca(2+)-insensitive PKC-epsilon isoform control basal expression of SNAP-25 in these cells.	Tetradecanoylphorbol Acetate	87-118	synaptosome associated protein 25	Bos taurus	20-27
12130708-4	2002	Furthermore, depletion of PKC by 12-O-tetradecanoylphorbol-13-acetate exposure (48 h, 1 microM) also prevented OFQ/N-mediated mu and ORL1 desensitization.	Tetradecanoylphorbol Acetate	33-69	opioid related nociceptin receptor 1	Homo sapiens	133-137
11389717-1	2001	4beta-Phorbol 12-myristate 13-acetate (TPA) increases the number of colonies resistant to methotrexate (MTX), mainly by amplification of the dihydrofolate reductase (dhfr) locus.	Tetradecanoylphorbol Acetate	0-37	dihydrofolate reductase	Cricetulus griseus	141-164
11389717-1	2001	4beta-Phorbol 12-myristate 13-acetate (TPA) increases the number of colonies resistant to methotrexate (MTX), mainly by amplification of the dihydrofolate reductase (dhfr) locus.	Tetradecanoylphorbol Acetate	0-37	dihydrofolate reductase	Cricetulus griseus	166-170
11389717-1	2001	4beta-Phorbol 12-myristate 13-acetate (TPA) increases the number of colonies resistant to methotrexate (MTX), mainly by amplification of the dihydrofolate reductase (dhfr) locus.	Tetradecanoylphorbol Acetate	39-42	dihydrofolate reductase	Cricetulus griseus	141-164
11389717-1	2001	4beta-Phorbol 12-myristate 13-acetate (TPA) increases the number of colonies resistant to methotrexate (MTX), mainly by amplification of the dihydrofolate reductase (dhfr) locus.	Tetradecanoylphorbol Acetate	39-42	dihydrofolate reductase	Cricetulus griseus	166-170
11389717-4	2001	TPA incubation increased the expression and activity of DHFR.	Tetradecanoylphorbol Acetate	0-3	dihydrofolate reductase	Cricetulus griseus	56-60
12446705-2	2003	In immortalized hypothalamic GnRH neurons (GT1-7 cells), which also express GnRH receptors, GnRH, epidermal growth factor (EGF), and phorbol 12-myristate 13-acetate (PMA) caused marked phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	133-164	mitogen-activated protein kinase 3	Mus musculus	204-210
11389717-13	2001	We conclude that one mechanism by which TPA enhances MTX resistance, mainly by gene amplification, is through an increase in Sp1 expression which leads to DHFR activation.	Tetradecanoylphorbol Acetate	40-43	dihydrofolate reductase	Cricetulus griseus	155-159
12465042-6	2003	In addition, activation of PKC by phorbol myristoyl acetate (PMA) activated Erk1/2 with concomitant increase in MMP-9 production.	Tetradecanoylphorbol Acetate	61-64	mitogen activated protein kinase 3	Rattus norvegicus	76-82
11407309-4	2001	TPA painting induced CD4+Tr cells in C3H/He (H-2k), C3H/HeN (H-2k), DBA/2 (H-2d) and AKR/N (H-2k) mice, but not in C57BL/6 (H-2b), C57BL/10 (H-2b), BALB/c (H-2d) and A/J (H-2a).	Tetradecanoylphorbol Acetate	0-3	histocompatibility 2, D region	Mus musculus	75-79
11407309-4	2001	TPA painting induced CD4+Tr cells in C3H/He (H-2k), C3H/HeN (H-2k), DBA/2 (H-2d) and AKR/N (H-2k) mice, but not in C57BL/6 (H-2b), C57BL/10 (H-2b), BALB/c (H-2d) and A/J (H-2a).	Tetradecanoylphorbol Acetate	0-3	histocompatibility 2, D region	Mus musculus	156-160
12202228-7	2002	The results implied that in LPS+PMA-stimulated monocyte/macrophages, the endogenous NF-IL6 could act via a site-independent pathway in upregulation of HIV-1 transcription.	Tetradecanoylphorbol Acetate	32-35	CCAAT enhancer binding protein beta	Homo sapiens	84-90
12101411-6	2002	A marked delay in TPA-induced intracellular translocation and downregulation of PKC alpha was observed in TNF-alpha(-/-) epidermis, which correlated with the deregulated TPA-induced AP-1 activation and c-Jun expression.	Tetradecanoylphorbol Acetate	18-21	jun proto-oncogene	Mus musculus	202-207
11278846-2	2001	This study demonstrates that sodium salicylate at a therapeutic concentration suppressed COX-2 gene transcription induced by phorbol 12-myristate 13-acetate and interleukin 1beta by inhibiting the binding of CCAAT/enhancer-binding protein beta to its promoter region of COX-2.	Tetradecanoylphorbol Acetate	125-156	CCAAT enhancer binding protein beta	Homo sapiens	208-243
12445732-7	2002	When activated with phorbol myristate acetate (10 ng/ml), sheep leukocytes showed a marked increase in CD11b expression and a decrease in L-selectin.	Tetradecanoylphorbol Acetate	20-45	integrin alpha-M	Ovis aries	103-108
11333365-6	2001	Further in vitro study showed that NAMDA potentiated phorbol-12 myristate-13 acetate (PMA)-induced c-Fos expression, AP1 binding activity, and late gene expression determined by chloramphenicol acetyltransferase (CAT) activity from AP1 containing tyrosine hydroxylase promoter-CAT fusion gene in SK-N-BE(2)C neurons.	Tetradecanoylphorbol Acetate	53-84	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-120
12111824-5	2002	The primary structure of the human BGT-1 protein predicts two putative phosphorylation sites for the Ca(2+)/diacylglicerol-dependent protein kinase (PKC), and treatment of U373 MG cells with the PKC activator phorbol 12-myristate-13-acetate (TPA) led to a concentration- and time-dependent decrease in [(3)H]GABA uptake.	Tetradecanoylphorbol Acetate	209-240	solute carrier family 6 member 12	Homo sapiens	35-40
12111824-5	2002	The primary structure of the human BGT-1 protein predicts two putative phosphorylation sites for the Ca(2+)/diacylglicerol-dependent protein kinase (PKC), and treatment of U373 MG cells with the PKC activator phorbol 12-myristate-13-acetate (TPA) led to a concentration- and time-dependent decrease in [(3)H]GABA uptake.	Tetradecanoylphorbol Acetate	242-245	solute carrier family 6 member 12	Homo sapiens	35-40
11333365-6	2001	Further in vitro study showed that NAMDA potentiated phorbol-12 myristate-13 acetate (PMA)-induced c-Fos expression, AP1 binding activity, and late gene expression determined by chloramphenicol acetyltransferase (CAT) activity from AP1 containing tyrosine hydroxylase promoter-CAT fusion gene in SK-N-BE(2)C neurons.	Tetradecanoylphorbol Acetate	53-84	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	232-235
12468040-2	2002	SH-SY5Y cells express the intracellular factors activated through the receptors of the TGFbeta superfamily members, Smad1 and Smad4, as in basal conditions or after differentiation with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or retinoic acid (RA).	Tetradecanoylphorbol Acetate	186-223	SMAD family member 1	Homo sapiens	116-121
11333365-6	2001	Further in vitro study showed that NAMDA potentiated phorbol-12 myristate-13 acetate (PMA)-induced c-Fos expression, AP1 binding activity, and late gene expression determined by chloramphenicol acetyltransferase (CAT) activity from AP1 containing tyrosine hydroxylase promoter-CAT fusion gene in SK-N-BE(2)C neurons.	Tetradecanoylphorbol Acetate	86-89	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-120
11333365-6	2001	Further in vitro study showed that NAMDA potentiated phorbol-12 myristate-13 acetate (PMA)-induced c-Fos expression, AP1 binding activity, and late gene expression determined by chloramphenicol acetyltransferase (CAT) activity from AP1 containing tyrosine hydroxylase promoter-CAT fusion gene in SK-N-BE(2)C neurons.	Tetradecanoylphorbol Acetate	86-89	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	232-235
11956220-10	2002	Co-transfection of the MAO B promoter with dominant negative forms of Ras, Raf-1, MEKK1, MEK1, MEK3, MEK7, ERK2, JNK1, and p38/RK inhibit the PMA-dependent activation of the MAO B promoter.	Tetradecanoylphorbol Acetate	142-145	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	75-80
11956220-10	2002	Co-transfection of the MAO B promoter with dominant negative forms of Ras, Raf-1, MEKK1, MEK1, MEK3, MEK7, ERK2, JNK1, and p38/RK inhibit the PMA-dependent activation of the MAO B promoter.	Tetradecanoylphorbol Acetate	142-145	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	82-87
12468040-2	2002	SH-SY5Y cells express the intracellular factors activated through the receptors of the TGFbeta superfamily members, Smad1 and Smad4, as in basal conditions or after differentiation with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or retinoic acid (RA).	Tetradecanoylphorbol Acetate	186-223	SMAD family member 4	Homo sapiens	126-131
12093473-5	2002	The zymosan-induced increase in iPLA2 activity was suppressed by pretreatment with 4beta-phorbol 12-myristate 13-acetate for 10 hr, by which PKCalpha and PKCdelta, but not PKCbeta and PKCepsilon, were depleted, and by Go6976, a PKCalpha inhibitor, but not rottlerin, a PKCdelta inhibitor.	Tetradecanoylphorbol Acetate	83-120	protein kinase C, beta	Mus musculus	172-179
12093473-5	2002	The zymosan-induced increase in iPLA2 activity was suppressed by pretreatment with 4beta-phorbol 12-myristate 13-acetate for 10 hr, by which PKCalpha and PKCdelta, but not PKCbeta and PKCepsilon, were depleted, and by Go6976, a PKCalpha inhibitor, but not rottlerin, a PKCdelta inhibitor.	Tetradecanoylphorbol Acetate	83-120	protein kinase C, epsilon	Mus musculus	184-194
11319768-9	2001	Interestingly, only TPA led to a coordinated increase in the levels of GDNF, GFR alpha-1 and GFR alpha-2 mRNAs.	Tetradecanoylphorbol Acetate	20-23	glial cell derived neurotrophic factor	Rattus norvegicus	71-75
12468040-2	2002	SH-SY5Y cells express the intracellular factors activated through the receptors of the TGFbeta superfamily members, Smad1 and Smad4, as in basal conditions or after differentiation with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or retinoic acid (RA).	Tetradecanoylphorbol Acetate	225-228	SMAD family member 1	Homo sapiens	116-121
11359422-0	2001	IL-5 priming of the PMA-induced oxidative metabolism of human eosinophils from allergic and normal subjects during a pollen season.	Tetradecanoylphorbol Acetate	20-23	interleukin 5	Homo sapiens	0-4
12468040-2	2002	SH-SY5Y cells express the intracellular factors activated through the receptors of the TGFbeta superfamily members, Smad1 and Smad4, as in basal conditions or after differentiation with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or retinoic acid (RA).	Tetradecanoylphorbol Acetate	225-228	SMAD family member 4	Homo sapiens	126-131
11359422-8	2001	IL-5 reduced the total PMA CL response both in control and patients" cells (P = 0.012 and 0.0054 resp.), whereas it primed it in terms of the t(1/2)rise of the curves, in both groups (P = 0.012 and 0.0015 resp.).	Tetradecanoylphorbol Acetate	23-26	interleukin 5	Homo sapiens	0-4
11359422-12	2001	Interleukin-5 primes equally the PMA-induced oxidative metabolism of human eosinophils from healthy or allergic subjects.	Tetradecanoylphorbol Acetate	33-36	interleukin 5	Homo sapiens	0-13
12468040-3	2002	TGF-beta1 and BMP-2 induce differentiation in SH-SY5Y cells by different pathways: the effect of TGF-beta1 is potentiated by TPA and the effect of BMP-2 is blocked by RA.	Tetradecanoylphorbol Acetate	125-128	bone morphogenetic protein 2	Homo sapiens	14-19
11359422-13	2001	The mechanism of IL-5 priming after PMA stimulation of oxygen radical production is MEK independent.	Tetradecanoylphorbol Acetate	36-39	interleukin 5	Homo sapiens	17-21
12585691-12	2002	Phorbol myristate acetate (PMA), but not alpha-PMA, reduced in more than 85% the number of L-[3H]-vesamicol-specific binding sites in chicken retina, confirming that activation of PKC can influence vesamicol binding to chicken VAChT.	Tetradecanoylphorbol Acetate	0-25	solute carrier family 18 member A3	Gallus gallus	227-232
12769655-1	2002	Proteolytic degradation of fibrin (fibrinolysis) is mediated by plasminogen and its activators, tissue-type plasminogen activator (tPA(1)) and urokinase (uPA).	Tetradecanoylphorbol Acetate	131-134	plasminogen activator, tissue	Mus musculus	96-129
12585691-12	2002	Phorbol myristate acetate (PMA), but not alpha-PMA, reduced in more than 85% the number of L-[3H]-vesamicol-specific binding sites in chicken retina, confirming that activation of PKC can influence vesamicol binding to chicken VAChT.	Tetradecanoylphorbol Acetate	27-30	solute carrier family 18 member A3	Gallus gallus	227-232
11310852-1	2001	Apolipoprotein C-II (apoC-II), which is known to activate lipoprotein lipase (LPL), was identified by ordered differential display (ODD)-polymerase chain reaction (PCR) as a cDNA fragment exhibiting a distinct increase in expression during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of promonocytic U937 cells into monocytes and macrophages.	Tetradecanoylphorbol Acetate	240-276	apolipoprotein C2	Homo sapiens	0-19
12113473-3	2002	The full-length KLF5 functions as a transactivator in HepG2 cells, and the stimulation of cells with 12-0-tetradecanoylphorbol-13-acetate (TPA) can modulate its transcriptional activity.	Tetradecanoylphorbol Acetate	139-142	Kruppel like factor 5	Homo sapiens	16-20
12430000-5	2002	Levels of expression of two genes, human flavoprotein subunit of complex II and JKTBP, were downregulated by TPA, and expression of two genes, human golgin p245 and bcl-xL, was upregulated.	Tetradecanoylphorbol Acetate	109-112	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	41-75
12113473-4	2002	Overexpression of KLF5 leads to an increase in the TPA response from VLTRE, a TPA-inducible enhancer element that shows keratinocyte specificity with respect to Rel/NF-kappaB binding.	Tetradecanoylphorbol Acetate	51-54	Kruppel like factor 5	Homo sapiens	18-22
12113473-4	2002	Overexpression of KLF5 leads to an increase in the TPA response from VLTRE, a TPA-inducible enhancer element that shows keratinocyte specificity with respect to Rel/NF-kappaB binding.	Tetradecanoylphorbol Acetate	78-81	Kruppel like factor 5	Homo sapiens	18-22
11310852-1	2001	Apolipoprotein C-II (apoC-II), which is known to activate lipoprotein lipase (LPL), was identified by ordered differential display (ODD)-polymerase chain reaction (PCR) as a cDNA fragment exhibiting a distinct increase in expression during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of promonocytic U937 cells into monocytes and macrophages.	Tetradecanoylphorbol Acetate	240-276	apolipoprotein C2	Homo sapiens	21-28
11310852-1	2001	Apolipoprotein C-II (apoC-II), which is known to activate lipoprotein lipase (LPL), was identified by ordered differential display (ODD)-polymerase chain reaction (PCR) as a cDNA fragment exhibiting a distinct increase in expression during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of promonocytic U937 cells into monocytes and macrophages.	Tetradecanoylphorbol Acetate	278-281	apolipoprotein C2	Homo sapiens	0-19
11310852-1	2001	Apolipoprotein C-II (apoC-II), which is known to activate lipoprotein lipase (LPL), was identified by ordered differential display (ODD)-polymerase chain reaction (PCR) as a cDNA fragment exhibiting a distinct increase in expression during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of promonocytic U937 cells into monocytes and macrophages.	Tetradecanoylphorbol Acetate	278-281	apolipoprotein C2	Homo sapiens	21-28
11310852-2	2001	The amount of apoC-II mRNA expression detectable in U937 cells significantly increased and reached a maximum 24-48 h after treatment with 32 nM TPA.	Tetradecanoylphorbol Acetate	144-147	apolipoprotein C2	Homo sapiens	14-21
12113473-9	2002	Considering the TPA-responsiveness and expression pattern, we propose that KLF5 like another member of its family KLF4/GKLF may play an important role in skin morphogenesis and carcinogenesis potentially via its interaction with NF-kappaB factors.	Tetradecanoylphorbol Acetate	16-19	Kruppel like factor 5	Homo sapiens	75-79
12454035-7	2002	Phorbol 12-myristate 13-acetate (PMA) caused PKC-alpha, -betaI, and - epsilon, initially present in the cytoplasm, to be translocated to the membrane and nuclear subcellular fractions and PKC-delta to be depleted from the cytoskeleton.	Tetradecanoylphorbol Acetate	0-31	protein kinase C delta	Homo sapiens	188-197
11310852-5	2001	Although apoC-II mRNA expression was markedly up-regulated during the induced differentiation of HL-60 cells into monocytes and macrophages with 32 nM TPA, such expression was not induced during the differentiation of HL-60 cells into granulocytes with 1.25% dimethyl sulfoxide.	Tetradecanoylphorbol Acetate	151-154	apolipoprotein C2	Homo sapiens	9-16
12454035-7	2002	Phorbol 12-myristate 13-acetate (PMA) caused PKC-alpha, -betaI, and - epsilon, initially present in the cytoplasm, to be translocated to the membrane and nuclear subcellular fractions and PKC-delta to be depleted from the cytoskeleton.	Tetradecanoylphorbol Acetate	33-36	protein kinase C delta	Homo sapiens	188-197
12112313-3	2002	Expression of dominant-negative c-jun (TAM67) in the mouse skin protects mice from 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced papillomagenesis without blocking mitogen-induced hyperproliferation.	Tetradecanoylphorbol Acetate	121-157	jun proto-oncogene	Mus musculus	32-37
12485318-9	2002	All the patient groups expressed (spontaneously and following stimulation with phorbol myristate acetate and ionomycin together with mite-extract proteins) greater amounts of CD69 and CD54 than did control subjects.	Tetradecanoylphorbol Acetate	79-104	CD69 molecule	Homo sapiens	175-179
12112313-3	2002	Expression of dominant-negative c-jun (TAM67) in the mouse skin protects mice from 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced papillomagenesis without blocking mitogen-induced hyperproliferation.	Tetradecanoylphorbol Acetate	159-162	jun proto-oncogene	Mus musculus	32-37
12054499-0	2002	FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway.	Tetradecanoylphorbol Acetate	10-13	protein kinase C delta	Homo sapiens	81-84
12054499-2	2002	Here, we investigated the effect of fibroblast growth factor-2 (FGF-2) and 12-O-tetradecanoylphorbol-13-acetate (TPA) on the secretion of type IV collagenases (MMP-2, MMP-9) in breast cancer MCF-7 cells.	Tetradecanoylphorbol Acetate	75-111	matrix metallopeptidase 2	Homo sapiens	160-165
11259631-7	2001	Topical 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment of K5-PKC alpha mice resulted in a 5-fold increase in epidermal COX-2 induction and a 2- to 3-fold increase in prostaglandin (PG) E(2) levels above that observed in TPA-treated wild-type mice.	Tetradecanoylphorbol Acetate	8-44	prostaglandin-endoperoxide synthase 2	Mus musculus	125-130
11259631-7	2001	Topical 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment of K5-PKC alpha mice resulted in a 5-fold increase in epidermal COX-2 induction and a 2- to 3-fold increase in prostaglandin (PG) E(2) levels above that observed in TPA-treated wild-type mice.	Tetradecanoylphorbol Acetate	46-49	prostaglandin-endoperoxide synthase 2	Mus musculus	125-130
11259631-8	2001	PD 98059, GF-109203X, or H7 could block cyclooxygenase-2 (COX-2) induction by TPA.	Tetradecanoylphorbol Acetate	78-81	prostaglandin-endoperoxide synthase 2	Mus musculus	40-56
11259631-8	2001	PD 98059, GF-109203X, or H7 could block cyclooxygenase-2 (COX-2) induction by TPA.	Tetradecanoylphorbol Acetate	78-81	prostaglandin-endoperoxide synthase 2	Mus musculus	58-63
11259631-10	2001	TPA-induced COX-2 expression was similar in C/EBP beta nullizygous and wild-type mice.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	12-17
11124968-2	2001	Here we report that CD45 negatively regulates monocyte differentiation by inhibiting phorbol 12-myristate 13-acetate (PMA)-dependent activation of protein kinase C (PKC) delta.	Tetradecanoylphorbol Acetate	85-116	protein kinase C delta	Homo sapiens	147-175
11124968-2	2001	Here we report that CD45 negatively regulates monocyte differentiation by inhibiting phorbol 12-myristate 13-acetate (PMA)-dependent activation of protein kinase C (PKC) delta.	Tetradecanoylphorbol Acetate	118-121	protein kinase C delta	Homo sapiens	147-175
12381534-10	2002	Addition of PKC-alpha inhibitor Go-6976 at a nanomolar concentration, other PKC inhibitors Go-6983 and GF-109203X, or PKC-delta-specific inhibitor rottlerin significantly inhibited PMA-mediated NT release.	Tetradecanoylphorbol Acetate	181-184	protein kinase C delta	Homo sapiens	118-127
11124968-4	2001	In addition, reduction in CD45 expression caused the duration of peak PMA-induced MEK and extracellular signal-regulated kinase (ERK) 1/2 activity to increase from 5 min to 30 min while leading to a 4-fold increase in PMA-dependent PKCdelta activation.	Tetradecanoylphorbol Acetate	70-73	protein kinase C delta	Homo sapiens	232-240
11124968-4	2001	In addition, reduction in CD45 expression caused the duration of peak PMA-induced MEK and extracellular signal-regulated kinase (ERK) 1/2 activity to increase from 5 min to 30 min while leading to a 4-fold increase in PMA-dependent PKCdelta activation.	Tetradecanoylphorbol Acetate	218-221	protein kinase C delta	Homo sapiens	232-240
11124968-6	2001	Finally, inhibitors of MEK (PD98059) and PKCdelta (rottlerin) completely blocked PMA-induced monocytic cell differentiation.	Tetradecanoylphorbol Acetate	81-84	protein kinase C delta	Homo sapiens	41-49
12384442-8	2002	The PMA-promoted calcium influx was also inhibited by omega-agatoxin-TK, a calcium channel blocker specific for Ca(v)2.1 channels.	Tetradecanoylphorbol Acetate	4-7	immunoglobulin lambda variable 3-1	Homo sapiens	112-120
11289135-7	2001	FP accelerated PMA-mediated dephosphorylation of the retinoblastoma protein (pRb), an event followed by pRb cleavage culminating in the complete loss of underphosphorylated pRb (approximately Mr 110,000) by 24 h. Finally, gel shift analysis revealed that coadministration of FP with PMA for 8 h led to diminished E2F/pRb binding compared to the effects of PMA alone.	Tetradecanoylphorbol Acetate	15-18	RB transcriptional corepressor 1	Homo sapiens	77-80
11880362-8	2002	In addition, diacylglycerol, a physiological PKC agonist, induced a significant increase in hMSH2 expression, whereas chelerythrine or calphostin C, two PKC inhibitors, significantly decreased TPA-induced hMSH2 expression.	Tetradecanoylphorbol Acetate	193-196	mutS homolog 2	Homo sapiens	92-97
11880362-8	2002	In addition, diacylglycerol, a physiological PKC agonist, induced a significant increase in hMSH2 expression, whereas chelerythrine or calphostin C, two PKC inhibitors, significantly decreased TPA-induced hMSH2 expression.	Tetradecanoylphorbol Acetate	193-196	mutS homolog 2	Homo sapiens	205-210
11877397-4	2002	Using promoter analysis in combination with electrophoretic mobility shift assays, we have demonstrated that an NFkappaB site located next to the TATA box, binds p50 and p65 heterodimer and is required for the induction of the IRF-7 gene by TPA and TNFalpha.	Tetradecanoylphorbol Acetate	241-244	RELA proto-oncogene, NF-kB subunit	Homo sapiens	170-173
11069897-2	2001	Bach1 forms a heterodimer with MafK, a member of the small Maf protein family (MafF, MafG, and MafK), which recognizes the NF-E2/Maf recognition element, a cis-regulatory motif containing a 12-O-tetradecanoylphorbol-13-acetate-responsive element.	Tetradecanoylphorbol Acetate	190-226	MAF bZIP transcription factor K	Homo sapiens	31-35
12082627-5	2002	The AP-1 activator phorbol 12-myristate 13-acetate (TPA) enhanced the binding of this DR4 AP-1 binding site to protein(s) in a nuclear extract from TPA-treated cells, increased luciferase activity of a reporter construct containing this site and induced DR4 expression at the transcription level.	Tetradecanoylphorbol Acetate	19-50	TNF receptor superfamily member 10a	Homo sapiens	254-257
12419948-1	2002	The effect of activins A, AB, and B on hepatocyte growth factor (HGF) synthesis stimulated by 12-O-tetradecanoylphorbol beta-acetate (TPA) was studied in MRC-5 human lung fibroblasts.	Tetradecanoylphorbol Acetate	134-137	hepatocyte growth factor	Homo sapiens	39-63
12082627-5	2002	The AP-1 activator phorbol 12-myristate 13-acetate (TPA) enhanced the binding of this DR4 AP-1 binding site to protein(s) in a nuclear extract from TPA-treated cells, increased luciferase activity of a reporter construct containing this site and induced DR4 expression at the transcription level.	Tetradecanoylphorbol Acetate	52-55	TNF receptor superfamily member 10a	Homo sapiens	86-89
12082627-5	2002	The AP-1 activator phorbol 12-myristate 13-acetate (TPA) enhanced the binding of this DR4 AP-1 binding site to protein(s) in a nuclear extract from TPA-treated cells, increased luciferase activity of a reporter construct containing this site and induced DR4 expression at the transcription level.	Tetradecanoylphorbol Acetate	52-55	TNF receptor superfamily member 10a	Homo sapiens	254-257
12082627-5	2002	The AP-1 activator phorbol 12-myristate 13-acetate (TPA) enhanced the binding of this DR4 AP-1 binding site to protein(s) in a nuclear extract from TPA-treated cells, increased luciferase activity of a reporter construct containing this site and induced DR4 expression at the transcription level.	Tetradecanoylphorbol Acetate	148-151	TNF receptor superfamily member 10a	Homo sapiens	86-89
12082627-5	2002	The AP-1 activator phorbol 12-myristate 13-acetate (TPA) enhanced the binding of this DR4 AP-1 binding site to protein(s) in a nuclear extract from TPA-treated cells, increased luciferase activity of a reporter construct containing this site and induced DR4 expression at the transcription level.	Tetradecanoylphorbol Acetate	148-151	TNF receptor superfamily member 10a	Homo sapiens	254-257
12082637-4	2002	A RNase-protection analysis showed that PMA stimulated the expression of several known anti-apoptotic genes (TRAF1, TRAF4, c-IAP-1, c-IAP-2, Bfl-1, Bcl-xl).	Tetradecanoylphorbol Acetate	40-43	TNF receptor associated factor 4	Homo sapiens	116-121
12082637-4	2002	A RNase-protection analysis showed that PMA stimulated the expression of several known anti-apoptotic genes (TRAF1, TRAF4, c-IAP-1, c-IAP-2, Bfl-1, Bcl-xl).	Tetradecanoylphorbol Acetate	40-43	baculoviral IAP repeat containing 2	Homo sapiens	123-130
11825899-4	2002	A CCAAT/enhancer-binding protein (C/EBP) binding site located at +22 to +30 was bound by C/EBP beta in a TPA-dependent manner and was solely responsible for the TPA responsiveness.	Tetradecanoylphorbol Acetate	161-164	CCAAT enhancer binding protein beta	Homo sapiens	89-99
11825899-5	2002	This increase in C/EBP beta activity occurs through transcriptional and posttranslational regulation, and the latter is mediated by activation of p90 ribosomal S6 kinase (RSK): co-expression of dominant negative RSK abolished the TPA-responsive and C/EBP beta-dependent transactivation.	Tetradecanoylphorbol Acetate	230-233	CCAAT enhancer binding protein beta	Homo sapiens	17-27
11825899-5	2002	This increase in C/EBP beta activity occurs through transcriptional and posttranslational regulation, and the latter is mediated by activation of p90 ribosomal S6 kinase (RSK): co-expression of dominant negative RSK abolished the TPA-responsive and C/EBP beta-dependent transactivation.	Tetradecanoylphorbol Acetate	230-233	CCAAT enhancer binding protein beta	Homo sapiens	249-259
11825899-6	2002	Also, TPA-responsive activation of GAL4-C/EBP beta chimera required the Ser residue known as the RSK target.	Tetradecanoylphorbol Acetate	6-9	CCAAT enhancer binding protein beta	Homo sapiens	40-50
11825899-10	2002	These observations suggest that the increase of C/EBP beta binding to the C/EBP site, which is in part mediated via activation of RSK, can primarily explain the TPA responsiveness of the IGF-I gene promoter.	Tetradecanoylphorbol Acetate	161-164	CCAAT enhancer binding protein beta	Homo sapiens	48-58
11956069-5	2002	The subsequent confirmation of the altered expression levels of the selected genes by semiquantitative reverse transcription-PCR demonstrated that overexpression of the antisense ING1 stimulated expression of 14 genes, which included cyclin B1, 12-O-tetradecanoylphorbol-13-acetate-inducible sequence 11, proto-oncogene DEK, and osteopontin, whereas we have detected transcriptional repression of 5 genes, including TPT1.	Tetradecanoylphorbol Acetate	245-281	secreted phosphoprotein 1	Mus musculus	329-340
11920638-3	2002	We show that a prolonged OHT treatment (for up to 7 days) led to a progressive increase in the level of phosphorylated p44/42 mitogen activated kinase (MAP kinase) induced by 10(-7) M TPA stimulation, without any significant change in the protein level.	Tetradecanoylphorbol Acetate	184-187	interferon induced protein 44	Homo sapiens	119-122
11988854-5	2002	Down-regulation of COX-2 by ginkgetin was also proved in the dorsal skin of ICR mouse treated by 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	97-133	cytochrome c oxidase II, mitochondrial	Mus musculus	19-24
11988854-5	2002	Down-regulation of COX-2 by ginkgetin was also proved in the dorsal skin of ICR mouse treated by 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	135-138	cytochrome c oxidase II, mitochondrial	Mus musculus	19-24
11799119-1	2002	The phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent stimulator of Erk, leads to the phosphorylation of 4E-BP1 and its dissociation from eIF4E.	Tetradecanoylphorbol Acetate	19-55	eukaryotic translation initiation factor 4E	Homo sapiens	156-161
11799119-1	2002	The phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent stimulator of Erk, leads to the phosphorylation of 4E-BP1 and its dissociation from eIF4E.	Tetradecanoylphorbol Acetate	57-60	eukaryotic translation initiation factor 4E	Homo sapiens	156-161
11777908-1	2002	We previously found that bikunin (bik), a Kunitz-type protease inhibitor, suppresses phorbol ester (PMA)-stimulated expression of urokinase-type plasminogen activator (uPA).	Tetradecanoylphorbol Acetate	100-103	alpha-1-microglobulin/bikunin precursor	Homo sapiens	25-32
11777908-1	2002	We previously found that bikunin (bik), a Kunitz-type protease inhibitor, suppresses phorbol ester (PMA)-stimulated expression of urokinase-type plasminogen activator (uPA).	Tetradecanoylphorbol Acetate	100-103	alpha-1-microglobulin/bikunin precursor	Homo sapiens	25-28
11857454-6	2002	Treatment of the cells with TPA increased p38 MAPK expression in cells from both control and endotoxin treated animals.	Tetradecanoylphorbol Acetate	28-31	mitogen activated protein kinase 14	Rattus norvegicus	42-45
11744714-8	2002	12-O-Tetradecanoyl phorbol 13-acetate (16 nm), a PKC activator, reproduced the effects of gp160 in untreated cells.	Tetradecanoylphorbol Acetate	0-37	glutamyl aminopeptidase	Homo sapiens	90-95
11853160-8	2002	ICAM-1 expression on CD4 T cells greatly increased following growth in 10 week-BALB/c mice receiving TPA than 6-week-old mice, however, a slight increase in growth occurred in 6-to-10-week-old animals in which TPA was absent.	Tetradecanoylphorbol Acetate	101-104	intercellular adhesion molecule 1	Mus musculus	0-6
11853160-8	2002	ICAM-1 expression on CD4 T cells greatly increased following growth in 10 week-BALB/c mice receiving TPA than 6-week-old mice, however, a slight increase in growth occurred in 6-to-10-week-old animals in which TPA was absent.	Tetradecanoylphorbol Acetate	210-213	intercellular adhesion molecule 1	Mus musculus	0-6
11872645-4	2002	K6-SSAT transgenic mice showed a 10-fold increase in the number of epidermal tumors that developed in response to a single application of 400 nmol of the tumor initiator 7,12-dimethylbenz[a]anthracene followed by twice weekly applications of 17 nmol of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate for 19 weeks.	Tetradecanoylphorbol Acetate	272-308	spermidine/spermine N1-acetyl transferase 1	Mus musculus	3-7
11772950-4	2002	Angiostatin blocked chemotaxis of neutrophils to CXCR2 chemokine receptor agonists (IL-8, MIP-2, and GROalpha), formyl-Met-Leu-Phe (fMLP), and 12-O-tetradecanoylphorbol 13-acetate, and repressed fMLP-induced mitochondrial activity.	Tetradecanoylphorbol Acetate	143-179	plasminogen	Mus musculus	0-11
11809859-4	2002	In C9 cells, phorbol-12-myristate-13-acetate (PMA) caused much greater phosphorylation of Pyk2 and ERK than the Ca(2+) ionophore ionomycin, and the effects of PMA and Ang II were abolished in PKC-depleted cells.	Tetradecanoylphorbol Acetate	13-44	protein kinase C delta	Homo sapiens	192-195
11809859-4	2002	In C9 cells, phorbol-12-myristate-13-acetate (PMA) caused much greater phosphorylation of Pyk2 and ERK than the Ca(2+) ionophore ionomycin, and the effects of PMA and Ang II were abolished in PKC-depleted cells.	Tetradecanoylphorbol Acetate	46-49	protein kinase C delta	Homo sapiens	192-195
12191614-7	2002	In contrast, phorbol 12-myristate 13-acetate-induced phosphorylation of MARCKS was scarcely inhibited by H-1152P.	Tetradecanoylphorbol Acetate	13-44	myristoylated alanine rich protein kinase C substrate	Homo sapiens	72-78
11795874-7	2002	Overexpression of a kinase-inactive dominant-negative mutant of PKCepsilon (K437R) decreased the growth inhibitory effect of PMA and also blocked the PMA-induced increase in the level of p21(Cip1) protein.	Tetradecanoylphorbol Acetate	125-128	protein kinase C, epsilon	Mus musculus	64-74
11584014-6	2002	Using PKC inhibitors and dominant negative PKC isoforms, we found that both PKCalpha and PKCdelta mediated the apoptotic effect of PMA, whereas only PKCalpha was involved in the effect of the DAG-lactone.	Tetradecanoylphorbol Acetate	131-134	protein kinase C delta	Homo sapiens	89-97
11782362-3	2002	In this study, we used inhibitors of Rsk-2 and MSK1 to decide which of these kinases was responsible for the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation of H3 in 10T(1/2) and Ciras-3 (H-ras-transformed 10T(1/2)) mouse fibroblasts.	Tetradecanoylphorbol Acetate	109-145	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	47-51
11782362-3	2002	In this study, we used inhibitors of Rsk-2 and MSK1 to decide which of these kinases was responsible for the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation of H3 in 10T(1/2) and Ciras-3 (H-ras-transformed 10T(1/2)) mouse fibroblasts.	Tetradecanoylphorbol Acetate	147-150	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	47-51
11782362-6	2002	H89, a potent MSK1 inhibitor, prevented TPA induction of H3 phosphorylation and diminished the TPA-induced expression of the c-fos and urokinase plasminogen activator genes.	Tetradecanoylphorbol Acetate	40-43	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	14-18
11782362-6	2002	H89, a potent MSK1 inhibitor, prevented TPA induction of H3 phosphorylation and diminished the TPA-induced expression of the c-fos and urokinase plasminogen activator genes.	Tetradecanoylphorbol Acetate	95-98	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	14-18
11968002-5	2002	However, the p44/p42 MAP kinase phosphorylation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a direct activator of PKC, or NaF, a direct activator of GTP-binding protein, was not affected by l-CAZ.	Tetradecanoylphorbol Acetate	59-95	mitogen-activated protein kinase 3	Mus musculus	13-16
11968002-5	2002	However, the p44/p42 MAP kinase phosphorylation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a direct activator of PKC, or NaF, a direct activator of GTP-binding protein, was not affected by l-CAZ.	Tetradecanoylphorbol Acetate	59-95	cyclin-dependent kinase 20	Mus musculus	17-20
11968002-5	2002	However, the p44/p42 MAP kinase phosphorylation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a direct activator of PKC, or NaF, a direct activator of GTP-binding protein, was not affected by l-CAZ.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 3	Mus musculus	13-16
11968002-5	2002	However, the p44/p42 MAP kinase phosphorylation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a direct activator of PKC, or NaF, a direct activator of GTP-binding protein, was not affected by l-CAZ.	Tetradecanoylphorbol Acetate	97-100	cyclin-dependent kinase 20	Mus musculus	17-20
12210744-6	2002	After 16 h incubation with OA plus phorbol 12-myristate 13-acetate (PMA), PKC delta staining on the lipid droplet surface was not seen, whereas the accumulation of lipid droplets was unaffected.	Tetradecanoylphorbol Acetate	35-66	protein kinase C delta	Homo sapiens	74-83
12086399-7	2002	These findings suggest that diarylheptanoids contained in Alpinia oxyphylla down-regulate COX-2 and iNOS expression through suppression of NF-kappaB activation in the TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	167-170	prostaglandin-endoperoxide synthase 2	Mus musculus	90-95
12448787-1	2002	The effects of phorbol 12-myristate, 13-acetate (PMA) on 5-hydroxytryptamine (5-HT)-evoked ion currents in the mouse 5-HT3A receptor were examined.	Tetradecanoylphorbol Acetate	49-52	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	117-123
12448787-2	2002	Perfusion with PMA caused a concentration dependent potentiation of 5-HT mediated currents and increased both potency and efficacy of 5-HT at the 5-HT3A receptor expressed in Xenopus oocytes.	Tetradecanoylphorbol Acetate	15-18	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	146-152
12448787-5	2002	Mutation of tyrosine 458 in the 5-HT3A receptor lacking intracellular serines and threonines reduced the PMA-induced potentiation of 5-HT evoked currents by approximately 55%.	Tetradecanoylphorbol Acetate	105-108	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	32-38
11779640-7	2001	The 12-O-tetradecanoylphorbol 13-acetate-induced monocytic differentiation of U937, which also resulted in growth arrest, down-regulated the expression of ZF5128 mRNA.	Tetradecanoylphorbol Acetate	4-40	zinc finger protein 324	Homo sapiens	155-161
11704537-6	2001	Secretion of SP-B and SP-C was stimulated three- to fivefold by terbutaline, 5"-(N-ethylcarboxyamido)adenosine, ATP, 12-O-tetradecanoylphorbol 13-acetate, and ionomycin.	Tetradecanoylphorbol Acetate	117-153	surfactant protein B	Rattus norvegicus	13-17
11748375-11	2001	Expression of cyclooxygenase-2 (COX-2) in TPA-stimulated mouse skin was markedly suppressed by Rg3 pretreatment.	Tetradecanoylphorbol Acetate	42-45	prostaglandin-endoperoxide synthase 2	Mus musculus	14-30
11748375-11	2001	Expression of cyclooxygenase-2 (COX-2) in TPA-stimulated mouse skin was markedly suppressed by Rg3 pretreatment.	Tetradecanoylphorbol Acetate	42-45	prostaglandin-endoperoxide synthase 2	Mus musculus	32-37
11746831-1	2001	The human myeloid HL-60 cell line and its cell variant HL-525 were used to study signaling events leading to apoptosis induction by phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC) enzymes.	Tetradecanoylphorbol Acetate	132-163	protein kinase C beta	Homo sapiens	205-208
11746831-1	2001	The human myeloid HL-60 cell line and its cell variant HL-525 were used to study signaling events leading to apoptosis induction by phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC) enzymes.	Tetradecanoylphorbol Acetate	165-168	protein kinase C beta	Homo sapiens	205-208
11746831-4	2001	By using this vector and specific neutralizing monoclonal antibodies (mAbs), it was established that PMA-induced apoptosis also called for an interaction between cell-surface alpha(5)beta(1)-integrin and its deposited ligand fibronectin (FN), which is downstream of PKC-beta activation.	Tetradecanoylphorbol Acetate	101-104	protein kinase C beta	Homo sapiens	266-274
11719466-10	2001	Taken together, this study shows that a PKC-epsilon-Raf-1-MEK-ERK-AP1 signaling cascade acts on a 12-O-tetradecanoylphorbol-13-acetate response element-like element to mediate hypoxia-induced GRP78 expression in human gastric cancer cells.	Tetradecanoylphorbol Acetate	98-134	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	52-57
11684327-2	2001	We show that the apoptosis of nerve growth factor (NGF)-deprived rat sympathetic neurons is delayed for about 24 h by treatment with O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	168-171	nerve growth factor	Rattus norvegicus	30-49
11684327-2	2001	We show that the apoptosis of nerve growth factor (NGF)-deprived rat sympathetic neurons is delayed for about 24 h by treatment with O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	168-171	nerve growth factor	Rattus norvegicus	51-54
11600418-5	2001	The mRNA levels of the NHE isoforms in Caco-2 cells were initially measured by a semiquantitative RT-PCR technique in response to PKC downregulation by long-term exposure to 1 microM 12-O-tetradecanoylphorbol-13-acetate (TPA) for 24 h. PKC downregulation resulted in an approximately 60% increase in the mRNA level for NHE3, but not for NHE1 or NHE2.	Tetradecanoylphorbol Acetate	183-219	solute carrier family 9 member C1	Homo sapiens	23-26
11600418-5	2001	The mRNA levels of the NHE isoforms in Caco-2 cells were initially measured by a semiquantitative RT-PCR technique in response to PKC downregulation by long-term exposure to 1 microM 12-O-tetradecanoylphorbol-13-acetate (TPA) for 24 h. PKC downregulation resulted in an approximately 60% increase in the mRNA level for NHE3, but not for NHE1 or NHE2.	Tetradecanoylphorbol Acetate	221-224	solute carrier family 9 member C1	Homo sapiens	23-26
11600418-7	2001	Consistent with the mRNA results, our data showed that amiloride-sensitive (22)Na(+) uptake was increased after incubation of Caco-2 cells with 1 microM TPA for 24 h. To elucidate the role of PKC-alpha, an isoform downregulated by TPA, the relative abundance of NHE isoform mRNA levels and the apical NHE activity were assessed in Caco-2 cells over- and underexpressing PKC-alpha.	Tetradecanoylphorbol Acetate	153-156	solute carrier family 9 member C1	Homo sapiens	262-265
11600418-7	2001	Consistent with the mRNA results, our data showed that amiloride-sensitive (22)Na(+) uptake was increased after incubation of Caco-2 cells with 1 microM TPA for 24 h. To elucidate the role of PKC-alpha, an isoform downregulated by TPA, the relative abundance of NHE isoform mRNA levels and the apical NHE activity were assessed in Caco-2 cells over- and underexpressing PKC-alpha.	Tetradecanoylphorbol Acetate	153-156	solute carrier family 9 member C1	Homo sapiens	301-304
11594749-1	2001	Interleukin-1 (IL-1) regulation of tPA in hepatocytes was studied in mouse hepatocyte line AML12.	Tetradecanoylphorbol Acetate	35-38	interleukin 1 complex	Mus musculus	0-13
11594749-1	2001	Interleukin-1 (IL-1) regulation of tPA in hepatocytes was studied in mouse hepatocyte line AML12.	Tetradecanoylphorbol Acetate	35-38	interleukin 1 complex	Mus musculus	15-19
11594749-2	2001	IL-1 induced transient accumulation of tPA mRNA as high as threefold by 2 h after the start of treatment.	Tetradecanoylphorbol Acetate	39-42	interleukin 1 complex	Mus musculus	0-4
11594749-7	2001	These results revealed that low-density lipoprotein receptor-related protein (LRP), which is known to be a receptor for tPA and to be blocked by RAP, was up-regulated by IL-1.	Tetradecanoylphorbol Acetate	120-123	interleukin 1 complex	Mus musculus	170-174
11448964-7	2001	mAbs generated against the MT1-MMP catalytic domain are shown to inhibit MT1-MMP enzymatic activity and to impair both phorbol 12-myristate 13-acetate-induced endothelial migration and invasion of collagen and fibrin gels.	Tetradecanoylphorbol Acetate	119-150	matrix metallopeptidase 14	Homo sapiens	27-34
11553022-8	2001	Incubation with phorbol 12-myristate 13-acetate, the PKC activator, enhanced the increase in Mn-SOD gene expression in response to transient hypoxia.	Tetradecanoylphorbol Acetate	16-47	superoxide dismutase 2	Homo sapiens	93-99
11532864-1	2001	The aim of this study was to determine the effects of 40% dietary energy restriction (DER) relative to ad libitum feeding on AP-1-DNA binding and expression of c-Jun protein and c-jun mRNA in SENCAR mouse skin treated with acetone or 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	234-270	jun proto-oncogene	Mus musculus	160-165
11532864-1	2001	The aim of this study was to determine the effects of 40% dietary energy restriction (DER) relative to ad libitum feeding on AP-1-DNA binding and expression of c-Jun protein and c-jun mRNA in SENCAR mouse skin treated with acetone or 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	272-275	jun proto-oncogene	Mus musculus	160-165
11532864-3	2001	AP-1-DNA binding, measured by electrophoretic mobility shift assay, showed that TPA treatment for 4 h increased AP-1-DNA binding by 2-fold over acetone controls (P &lt; 0.05) and that DER reduced basal and TPA-induced AP-1-DNA binding in comparison with ad libitum fed groups in sham-operated mice (P &lt; 0.05).	Tetradecanoylphorbol Acetate	80-83	jun proto-oncogene	Mus musculus	0-4
11532864-3	2001	AP-1-DNA binding, measured by electrophoretic mobility shift assay, showed that TPA treatment for 4 h increased AP-1-DNA binding by 2-fold over acetone controls (P &lt; 0.05) and that DER reduced basal and TPA-induced AP-1-DNA binding in comparison with ad libitum fed groups in sham-operated mice (P &lt; 0.05).	Tetradecanoylphorbol Acetate	80-83	jun proto-oncogene	Mus musculus	112-116
11532864-3	2001	AP-1-DNA binding, measured by electrophoretic mobility shift assay, showed that TPA treatment for 4 h increased AP-1-DNA binding by 2-fold over acetone controls (P &lt; 0.05) and that DER reduced basal and TPA-induced AP-1-DNA binding in comparison with ad libitum fed groups in sham-operated mice (P &lt; 0.05).	Tetradecanoylphorbol Acetate	80-83	jun proto-oncogene	Mus musculus	112-116
11532864-3	2001	AP-1-DNA binding, measured by electrophoretic mobility shift assay, showed that TPA treatment for 4 h increased AP-1-DNA binding by 2-fold over acetone controls (P &lt; 0.05) and that DER reduced basal and TPA-induced AP-1-DNA binding in comparison with ad libitum fed groups in sham-operated mice (P &lt; 0.05).	Tetradecanoylphorbol Acetate	206-209	jun proto-oncogene	Mus musculus	0-4
11532864-4	2001	TPA treatment increased c-Jun protein levels in control fed mice (4-fold) and in DER mice (2-fold) over basal levels 4 h post-treatment (P &lt; 0.05).	Tetradecanoylphorbol Acetate	0-3	jun proto-oncogene	Mus musculus	24-29
11532864-6	2001	TPA induction of c-jun mRNA was also reduced by DER compared with ad libitum fed mice (P &lt; 0.05).	Tetradecanoylphorbol Acetate	0-3	jun proto-oncogene	Mus musculus	17-22
11500047-2	2001	Here we showed that in cultured human vascular smooth muscle cells (SMC), the PKC stimulator phorbol 12-myristate 13-acetate (PMA) inhibited [(3)H]thymidine incorporation in response to the growth factor PDGF associated with downregulation of PDGFbeta (but not alpha) receptors, which was recovered to normal level after PKC was depleted.	Tetradecanoylphorbol Acetate	93-124	protein kinase C beta	Homo sapiens	78-81
11500047-2	2001	Here we showed that in cultured human vascular smooth muscle cells (SMC), the PKC stimulator phorbol 12-myristate 13-acetate (PMA) inhibited [(3)H]thymidine incorporation in response to the growth factor PDGF associated with downregulation of PDGFbeta (but not alpha) receptors, which was recovered to normal level after PKC was depleted.	Tetradecanoylphorbol Acetate	93-124	protein kinase C beta	Homo sapiens	321-324
11500047-2	2001	Here we showed that in cultured human vascular smooth muscle cells (SMC), the PKC stimulator phorbol 12-myristate 13-acetate (PMA) inhibited [(3)H]thymidine incorporation in response to the growth factor PDGF associated with downregulation of PDGFbeta (but not alpha) receptors, which was recovered to normal level after PKC was depleted.	Tetradecanoylphorbol Acetate	126-129	protein kinase C beta	Homo sapiens	78-81
11500047-2	2001	Here we showed that in cultured human vascular smooth muscle cells (SMC), the PKC stimulator phorbol 12-myristate 13-acetate (PMA) inhibited [(3)H]thymidine incorporation in response to the growth factor PDGF associated with downregulation of PDGFbeta (but not alpha) receptors, which was recovered to normal level after PKC was depleted.	Tetradecanoylphorbol Acetate	126-129	protein kinase C beta	Homo sapiens	321-324
11507057-6	2001	TPA increased activator protein-1 (AP-1) binding activity within 6 h in nontransgenic mice, but increased AP-1 binding activity was delayed in the transgenic mice.	Tetradecanoylphorbol Acetate	0-3	jun proto-oncogene	Mus musculus	14-33
11507057-6	2001	TPA increased activator protein-1 (AP-1) binding activity within 6 h in nontransgenic mice, but increased AP-1 binding activity was delayed in the transgenic mice.	Tetradecanoylphorbol Acetate	0-3	jun proto-oncogene	Mus musculus	35-39
11502282-0	2001	Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix.	Tetradecanoylphorbol Acetate	14-17	prostaglandin-endoperoxide synthase 2	Mus musculus	26-42
11502282-2	2001	Here, in order to find in vivo effects, inhibition by wogonin of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 expression and anti-inflammatory activity in vivo were investigated.	Tetradecanoylphorbol Acetate	65-101	prostaglandin-endoperoxide synthase 2	Mus musculus	116-132
11502282-2	2001	Here, in order to find in vivo effects, inhibition by wogonin of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 expression and anti-inflammatory activity in vivo were investigated.	Tetradecanoylphorbol Acetate	103-106	prostaglandin-endoperoxide synthase 2	Mus musculus	116-132
11443060-4	2001	Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) caused significant increases in APLP2 shedding.	Tetradecanoylphorbol Acetate	40-71	amyloid beta precursor like protein 2	Homo sapiens	110-115
11443060-4	2001	Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) caused significant increases in APLP2 shedding.	Tetradecanoylphorbol Acetate	73-76	amyloid beta precursor like protein 2	Homo sapiens	110-115
11443064-5	2001	PKC delta was activated by PMA but did not translocate.	Tetradecanoylphorbol Acetate	27-30	protein kinase C delta	Homo sapiens	0-9
11560779-0	2001	TPA-activated transcription of the human MnSOD gene: role of transcription factors Sp-1 and Egr-1.	Tetradecanoylphorbol Acetate	0-3	superoxide dismutase 2	Homo sapiens	41-46
11560779-6	2001	We also found that the basal promoter is responsive to 12-O-tetradecanoylphorbol-13-acetate (TPA)-activated hMnSOD transcription in the human hepatocarcinoma cell line HepG2.	Tetradecanoylphorbol Acetate	55-91	superoxide dismutase 2	Homo sapiens	108-114
11560779-6	2001	We also found that the basal promoter is responsive to 12-O-tetradecanoylphorbol-13-acetate (TPA)-activated hMnSOD transcription in the human hepatocarcinoma cell line HepG2.	Tetradecanoylphorbol Acetate	93-96	superoxide dismutase 2	Homo sapiens	108-114
11560779-7	2001	The contributions of these binding sites and the roles of the transcription factors Egr-1, AP-2, and Sp1 in the activation of hMnSOD transcription by TPA were investigated by site-directed mutation analysis, Western blotting, and overexpression of transcription factors.	Tetradecanoylphorbol Acetate	150-153	superoxide dismutase 2	Homo sapiens	126-132
11560779-8	2001	The results showed that Sp1 plays a positive role for both basal and TPA-activated hMnSOD transcription, whereas overexpression of Egr-1 has a negative role in the basal promoter activity without any effect on TPA-mediated activation of hMnSOD transcription.	Tetradecanoylphorbol Acetate	69-72	superoxide dismutase 2	Homo sapiens	83-89
11592732-7	2001	Furthermore, we observed that DHA significantly inhibited PMA-induced translocation of two PKC isoforms, PKC alpha and PKC epsilon, from cytosol to plasma membrane.	Tetradecanoylphorbol Acetate	58-61	protein kinase C, epsilon	Mus musculus	119-130
11472441-3	2001	We have now investigated the effect of metalloproteinase inhibitors and a serine proteinase inhibitor on the shedding of Fc gamma RIIIb induced by phorbol 12-myristate 13-acetate (PMA) or cytochalasin B (cyto B) + N-formyl-methionyl-leucyl-phenylalanine (fMLP).	Tetradecanoylphorbol Acetate	147-178	Fc gamma receptor IIIb	Homo sapiens	121-135
11069897-2	2001	Bach1 forms a heterodimer with MafK, a member of the small Maf protein family (MafF, MafG, and MafK), which recognizes the NF-E2/Maf recognition element, a cis-regulatory motif containing a 12-O-tetradecanoylphorbol-13-acetate-responsive element.	Tetradecanoylphorbol Acetate	190-226	MAF bZIP transcription factor K	Homo sapiens	95-99
11487146-7	2001	The present results suggested that TNF-alpha stimulates PA activity via an enhancement of tPA gene expression in HDP cells and MMP-2 activity, and further that tPA-activated TNF-alpha stimulated MMP-9.	Tetradecanoylphorbol Acetate	160-163	matrix metallopeptidase 2	Homo sapiens	127-132
11238722-1	2001	Tyrosine hydroxylase (TH) gene promoter activity is increased in PC12 cells that are treated with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	117-153	tyrosine hydroxylase	Rattus norvegicus	0-20
11238722-1	2001	Tyrosine hydroxylase (TH) gene promoter activity is increased in PC12 cells that are treated with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	117-153	tyrosine hydroxylase	Rattus norvegicus	22-24
11238722-1	2001	Tyrosine hydroxylase (TH) gene promoter activity is increased in PC12 cells that are treated with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	155-158	tyrosine hydroxylase	Rattus norvegicus	0-20
11238950-5	2001	We also found that the Rac1-GTP level decreased after stimulation with TPA and that the Rac1-IQGAP1 complexes decreased, while the IQGAP1-beta-catenin complexes increased during action of TPA.	Tetradecanoylphorbol Acetate	188-191	Rac family small GTPase 1	Canis lupus familiaris	23-27
11238950-5	2001	We also found that the Rac1-GTP level decreased after stimulation with TPA and that the Rac1-IQGAP1 complexes decreased, while the IQGAP1-beta-catenin complexes increased during action of TPA.	Tetradecanoylphorbol Acetate	188-191	Rac family small GTPase 1	Canis lupus familiaris	88-92
11238950-6	2001	Constitutively active Rac1 and IQGAP1 carboxyl terminus, a putative dominant-negative mutant of IQGAP1, inhibited the disappearance of alpha-catenin from sites of cell-cell contact induced by TPA.	Tetradecanoylphorbol Acetate	192-195	Rac family small GTPase 1	Canis lupus familiaris	22-26
11169763-9	2001	Treatment with tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), which phosphorylates fascin and decreases its affinity for actin, resulted in loss of all actin bundles from growth cones.	Tetradecanoylphorbol Acetate	30-66	fascin actin-bundling protein 1	Homo sapiens	95-101
11169763-9	2001	Treatment with tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), which phosphorylates fascin and decreases its affinity for actin, resulted in loss of all actin bundles from growth cones.	Tetradecanoylphorbol Acetate	68-71	fascin actin-bundling protein 1	Homo sapiens	95-101
11158244-7	2001	PMA treatment also produced an increase in the phosphorylation of serine 890 on the NR1 subunit, a known PKC site, at 5 min with phosphorylation returning to near basal levels by 10 min while tyrosine phosphorylation of NR2A and NR2B was sustained for up to 15 min.	Tetradecanoylphorbol Acetate	0-3	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	84-87
11139333-5	2001	LTD(4)-induced Ca(2+) signaling was significantly suppressed in cells pretreated with TPA for 15 min and was abolished when the pretreatment was prolonged to 2 h. Immunoblot analysis revealed that the reduction in the LTD(4)-induced calcium signal coincided with a reduction in the cellular content of PKCepsilon and, to a limited extent, PKCdelta.	Tetradecanoylphorbol Acetate	86-89	protein kinase C delta	Homo sapiens	339-347
12064598-2	2001	Stimulation of cardiomyocytes with phorbol 12-myristate 13-acetate (PMA) increased the fraction of the slower migrating (&gt; or = 45 kDa) and more extensively phosphorylated Cx43 species.	Tetradecanoylphorbol Acetate	35-66	gap junction protein alpha 1	Homo sapiens	175-179
12064598-2	2001	Stimulation of cardiomyocytes with phorbol 12-myristate 13-acetate (PMA) increased the fraction of the slower migrating (&gt; or = 45 kDa) and more extensively phosphorylated Cx43 species.	Tetradecanoylphorbol Acetate	68-71	gap junction protein alpha 1	Homo sapiens	175-179
12064598-4	2001	Selective inhibition of PKCE significantly decreased baseline levels of Cx43 phosphorylation and the PMA-induced accumulation of &gt; or = 45 kDa Cx43.	Tetradecanoylphorbol Acetate	101-104	gap junction protein alpha 1	Homo sapiens	146-150
11149424-0	2001	Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition.	Tetradecanoylphorbol Acetate	85-121	zinc finger protein 148	Mus musculus	221-227
11042219-5	2000	The results also demonstrate that TPA-induced ROS production is required for activation of the MEK kinase-1 (MEKK-1)--&gt; SAPK pathway.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	95-107
11042219-5	2000	The results also demonstrate that TPA-induced ROS production is required for activation of the MEK kinase-1 (MEKK-1)--&gt; SAPK pathway.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	109-115
11175257-4	2000	Analysis of PKC isoform expression by immunoblot shows that TPA-induced downregulation of PKC alpha and PKC delta is delayed in cells pre-treated with calpeptin, and that this correlates with an increase of these isoforms in the membrane fraction of cells.	Tetradecanoylphorbol Acetate	60-63	protein kinase C delta	Homo sapiens	104-113
11175257-6	2000	Expression of constitutively activated PKC alpha or PKC delta, but not kinase negative mutants of these isoforms, or constitutively activated PKC epsilon, induces apoptosis in salivary acinar cells, suggesting a role for these isoforms in TPA-induced apoptosis.	Tetradecanoylphorbol Acetate	239-242	protein kinase C delta	Homo sapiens	52-61
11125308-4	2000	However, following stimulation with lipopolysaccharide or phorbol myristate acetate/calcium ionophore, peritoneal cells from H2(b) mice synthesised significantly more IL-1 beta, TNF-alpha, TNFR and IFN-gamma protein and IFN-gamma mRNA than cells from congenic H2(k) or H2(d) mice.	Tetradecanoylphorbol Acetate	58-83	histocompatibility 2, D region	Mus musculus	269-274
11161966-5	2000	TPA markedly enhanced expression of all three IGFBPs produced by SK-N-SH cells.	Tetradecanoylphorbol Acetate	0-3	insulin like growth factor binding protein 2	Homo sapiens	46-52
11089555-16	2000	When PKCdelta levels were reduced by pretreatment with 500 nM TPA, neither bFGF nor 10 nM TPA suppressed apoptosis.	Tetradecanoylphorbol Acetate	62-65	protein kinase C delta	Homo sapiens	5-13
11056390-3	2000	When human polymorphonuclear leukocytes (PMNs) were stimulated with phorbol myristate acetate (PMA), p40(phox) was translocated to the membrane along with p67(phox), and not was released into the cytosol.	Tetradecanoylphorbol Acetate	68-93	interleukin 9	Homo sapiens	159-163
11056390-3	2000	When human polymorphonuclear leukocytes (PMNs) were stimulated with phorbol myristate acetate (PMA), p40(phox) was translocated to the membrane along with p67(phox), and not was released into the cytosol.	Tetradecanoylphorbol Acetate	95-98	interleukin 9	Homo sapiens	101-104
11056390-3	2000	When human polymorphonuclear leukocytes (PMNs) were stimulated with phorbol myristate acetate (PMA), p40(phox) was translocated to the membrane along with p67(phox), and not was released into the cytosol.	Tetradecanoylphorbol Acetate	95-98	interleukin 9	Homo sapiens	105-109
11056390-3	2000	When human polymorphonuclear leukocytes (PMNs) were stimulated with phorbol myristate acetate (PMA), p40(phox) was translocated to the membrane along with p67(phox), and not was released into the cytosol.	Tetradecanoylphorbol Acetate	95-98	interleukin 9	Homo sapiens	159-163
10915802-4	2000	Here, we show that phorbol 12-myristate 13-acetate, a direct activator of PKC, causes the dephosphorylation and desensitization of NPR-B.	Tetradecanoylphorbol Acetate	19-50	natriuretic peptide receptor 2	Homo sapiens	131-136
11054542-19	2000	Retinoic acid compounds and the phorbol ester, PMA were found to stimulate BMP-2 and, to a lesser degree, BMP-4.	Tetradecanoylphorbol Acetate	47-50	bone morphogenetic protein 2	Homo sapiens	75-80
11054542-19	2000	Retinoic acid compounds and the phorbol ester, PMA were found to stimulate BMP-2 and, to a lesser degree, BMP-4.	Tetradecanoylphorbol Acetate	47-50	bone morphogenetic protein 4	Homo sapiens	106-111
11054542-20	2000	The combination of all trans-RA and PMA caused a synergistic increase in BMP-2 promoter activity and endogenous mRNA.	Tetradecanoylphorbol Acetate	36-39	bone morphogenetic protein 2	Homo sapiens	73-78
11014215-7	2000	In addition, the GnRHa- and TPA-mediated decrease in the human GnRHR promoter activity was reversed by a specific protein kinase C (PKC) inhibitor, GF109203X, or depletion of PKC by TPA pretreatment.	Tetradecanoylphorbol Acetate	28-31	gonadotropin releasing hormone receptor	Homo sapiens	63-68
11014215-7	2000	In addition, the GnRHa- and TPA-mediated decrease in the human GnRHR promoter activity was reversed by a specific protein kinase C (PKC) inhibitor, GF109203X, or depletion of PKC by TPA pretreatment.	Tetradecanoylphorbol Acetate	182-185	gonadotropin releasing hormone receptor	Homo sapiens	63-68
10908559-7	2000	The ability of Id-1 to postpone, but not prevent, senescence may be related to partial inhibition of p16 expression, as the Id-1-overexpressing cultures displayed a decreased capacity for 12-O-tetradecanoylphorbol-13-acetate-mediated p16 induction.	Tetradecanoylphorbol Acetate	188-224	inhibitor of DNA binding 1, HLH protein	Homo sapiens	124-128
10960082-8	2000	In addition, PKC-depleted astrocyte cultures by overnight treatment with PMA no longer responded to PMA or IL-1.	Tetradecanoylphorbol Acetate	73-76	interleukin 1 complex	Mus musculus	107-111
10978779-3	2000	We found that the expression of trkA was dramatically induced by the two megakaryocyte lineage inducers sodium butyrate (NaBut) and phorbol 12-myristate 13-acetate (PMA), but not by the two erythrocyte lineage inducers hemin or 1-beta-D-arabinofuranosyl cytosine (Ara-C).	Tetradecanoylphorbol Acetate	132-163	neurotrophic receptor tyrosine kinase 1	Homo sapiens	32-36
10978779-3	2000	We found that the expression of trkA was dramatically induced by the two megakaryocyte lineage inducers sodium butyrate (NaBut) and phorbol 12-myristate 13-acetate (PMA), but not by the two erythrocyte lineage inducers hemin or 1-beta-D-arabinofuranosyl cytosine (Ara-C).	Tetradecanoylphorbol Acetate	165-168	neurotrophic receptor tyrosine kinase 1	Homo sapiens	32-36
10953055-6	2000	PTx also inhibited ERK1/2 activation in response to the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) as well as activation of c-Raf-1 by EGF and CCK.	Tetradecanoylphorbol Acetate	70-106	mitogen activated protein kinase 3	Rattus norvegicus	19-25
10953055-6	2000	PTx also inhibited ERK1/2 activation in response to the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) as well as activation of c-Raf-1 by EGF and CCK.	Tetradecanoylphorbol Acetate	108-111	mitogen activated protein kinase 3	Rattus norvegicus	19-25
10985305-4	2000	Stimulation of these cells with anti-CD28 antibody, and either phorbol 12-myristate 13-acetate (PMA) or anti-CD3, activates signal transduction pathways and results in IL-2 production and IL-2 receptor alpha-chain (CD25) expression.	Tetradecanoylphorbol Acetate	63-94	interleukin 2 receptor subunit alpha	Homo sapiens	215-219
10985305-4	2000	Stimulation of these cells with anti-CD28 antibody, and either phorbol 12-myristate 13-acetate (PMA) or anti-CD3, activates signal transduction pathways and results in IL-2 production and IL-2 receptor alpha-chain (CD25) expression.	Tetradecanoylphorbol Acetate	96-99	interleukin 2 receptor subunit alpha	Homo sapiens	215-219
11041200-2	2000	TPA-induced PKC activation resulted in dephosphorylation of pRb and subsequently induced ML-1 differentiation based on morphological changes and CD14 expression.	Tetradecanoylphorbol Acetate	0-3	RB transcriptional corepressor 1	Homo sapiens	60-63
11041200-2	2000	TPA-induced PKC activation resulted in dephosphorylation of pRb and subsequently induced ML-1 differentiation based on morphological changes and CD14 expression.	Tetradecanoylphorbol Acetate	0-3	CD14 molecule	Homo sapiens	145-149
11041200-4	2000	Preinhibition of PP-1 and PP-2a activities with 1-100 nM okadaic acid dose-dependently blunted the decrease in the phosphorylation status of pRb obtained with TPA and overrode cell cycle arrest.	Tetradecanoylphorbol Acetate	159-162	RB transcriptional corepressor 1	Homo sapiens	141-144
10947162-8	2000	Protein kinase C activation with PMA or indolactam restored ERK 1/2 activation and TNF secretion.	Tetradecanoylphorbol Acetate	33-36	mitogen-activated protein kinase 3	Mus musculus	60-67
10806212-4	2000	Both cell lines expressed an array of conventional (alpha, betaI, betaII, and gamma) and novel (theta and epsilon) PKC isozymes that can be activated by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	153-178	protein kinase C delta	Homo sapiens	115-118
10806212-4	2000	Both cell lines expressed an array of conventional (alpha, betaI, betaII, and gamma) and novel (theta and epsilon) PKC isozymes that can be activated by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	180-183	protein kinase C delta	Homo sapiens	115-118
10914330-2	2000	The phorbol ester TPA reduced SP-A1 and SP-A2 promoter activity to approximately 35% to 45% compared to that of control cells.	Tetradecanoylphorbol Acetate	18-21	surfactant protein A1	Homo sapiens	30-35
10914330-3	2000	The inhibitory effect of TPA was significantly reduced upon removal of the region +64/+394 relative to the SP-A1 transcription start site.	Tetradecanoylphorbol Acetate	25-28	surfactant protein A1	Homo sapiens	107-112
10914330-4	2000	Using NCI-H441 nuclear proteins, electromobility shift assay analysis showed that the intron region +309/+329 of SP-A1 and the corresponding region of SP-A2 formed sequence-specific DNA/protein complexes that were induced by TPA exposure.	Tetradecanoylphorbol Acetate	225-228	surfactant protein A1	Homo sapiens	113-118
10914330-5	2000	The region +318/+324 of SP-A1 contains sequences similar to a consensus AP-1 binding site, TGACTGA (TCACTGA for SP-A2), which when mutated (TGAGAGT) prevented the formation of the TPA-induced DNA/protein complex.	Tetradecanoylphorbol Acetate	180-183	surfactant protein A1	Homo sapiens	24-29
10859385-4	2000	We show that although a single BRRF1 mRNA species is induced by 12-O-tetradecanoylphorbol 13-acetate/sodium butyrate in several EBV-infected B cell lines, in Akata cells treated with anti-IgG two BRRF1 mRNAs can be detected.	Tetradecanoylphorbol Acetate	64-100	protein G49	Human gammaherpesvirus 4	31-36
10940738-6	2000	VIP and PACAP38 activation of ERK2 was blocked by the protein kinase A inhibitor H89, whereas the protein kinase C inhibitor GF109203X, or prior PMA-induced depletion of the protein kinases C, failed to inhibit VIP and PACAP38 activation of ERK2.	Tetradecanoylphorbol Acetate	145-148	mitogen activated protein kinase 1	Rattus norvegicus	30-34
10867029-4	2000	Arachidonic acid release and eicosanoid production induced by stimuli that do (A23187, zymosan) or do not (phorbol myristate acetate (PMA), okadaic acid) mobilize calcium were quantitatively suppressed in cPLA(2)-deficient mouse peritoneal macrophages.	Tetradecanoylphorbol Acetate	107-132	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	205-212
10816429-9	2000	In contrast, phosphatidylinositol 3-kinase (PI 3-kinase) and protein kinase B (PKB) activation by insulin and HGF is strong and sustained, whereas it is weak and transient with EGF and absent in the presence of TSH or PMA.	Tetradecanoylphorbol Acetate	218-221	AKT serine/threonine kinase 2	Canis lupus familiaris	61-77
10816429-9	2000	In contrast, phosphatidylinositol 3-kinase (PI 3-kinase) and protein kinase B (PKB) activation by insulin and HGF is strong and sustained, whereas it is weak and transient with EGF and absent in the presence of TSH or PMA.	Tetradecanoylphorbol Acetate	218-221	AKT serine/threonine kinase 2	Canis lupus familiaris	79-82
10825394-6	2000	Immunoblot analysis revealed that TPA induced prolonged hyperphosphorylation of Raf-1 and activation of extracellular-regulated/mitogen-activated protein kinases 1 and 2 in untransfected LNCaP cells, as did bryostatin 1 in PKCalpha-overexpressing cells.	Tetradecanoylphorbol Acetate	34-37	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	80-85
10849366-8	2000	The levels of c-Myc and Mad1 mRNAs and proteins increased within 3 h of anti-mu stimulation, and the levels were further enhanced by TPA.	Tetradecanoylphorbol Acetate	133-136	MAX dimerization protein 1	Homo sapiens	24-28
10849366-9	2000	Furthermore, the expressions of both c-Myc and Mad1 were reduced by forskolin, which also inhibited the anti-mu + TPA driven growth and differentiation of the B lymphocytes.	Tetradecanoylphorbol Acetate	114-117	MAX dimerization protein 1	Homo sapiens	47-51
10753934-1	2000	Stimulation of serum-starved human embryonic kidney (HEK) 293 cells with either the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), or insulin resulted in increases in the phosphorylation of 4E-BP1 and p70 S6 kinase, eIF4F assembly, and protein synthesis.	Tetradecanoylphorbol Acetate	99-135	eukaryotic translation initiation factor 4E	Homo sapiens	228-233
10753934-1	2000	Stimulation of serum-starved human embryonic kidney (HEK) 293 cells with either the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), or insulin resulted in increases in the phosphorylation of 4E-BP1 and p70 S6 kinase, eIF4F assembly, and protein synthesis.	Tetradecanoylphorbol Acetate	137-140	eukaryotic translation initiation factor 4E	Homo sapiens	228-233
10775036-5	2000	PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1.	Tetradecanoylphorbol Acetate	0-3	interferon induced protein 44	Homo sapiens	79-82
10775036-5	2000	PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1.	Tetradecanoylphorbol Acetate	175-178	interferon induced protein 44	Homo sapiens	79-82
10715515-3	2000	CD40 expression was higher on cord blood B cells compared to adult B cells after stimulation with PMA and ionomycin, but similar on adult and cord blood B cells activated by CD3-stimulated T cells.	Tetradecanoylphorbol Acetate	98-101	CD40 molecule	Homo sapiens	0-4
10770494-8	2000	Direct activation of PKC by phorbol myristate acetate, however, was not sufficient to promote induction of relaxin mRNA expression.	Tetradecanoylphorbol Acetate	28-53	protein kinase C, delta	Rattus norvegicus	21-24
10749124-6	2000	Treatment of BK5.IGF-1 transgenic mice with multiple topical applications of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, in the absence of tumor initiation led to the development of additional skin papillomas.	Tetradecanoylphorbol Acetate	96-132	insulin-like growth factor 1	Mus musculus	17-22
10713460-6	2000	The TPA-induced monocytic differentiation of U937, which also resulted in growth arrest, abruptly downregulated the expression of 3-PGDH.	Tetradecanoylphorbol Acetate	4-7	phosphoglycerate dehydrogenase	Homo sapiens	130-136
10713460-7	2000	Removal of TPA restored cell growth through the retrodifferentiation process and subsequent expression of 3-PGDH.	Tetradecanoylphorbol Acetate	11-14	phosphoglycerate dehydrogenase	Homo sapiens	106-112
10712588-4	2000	Co-treatment of cells with okadaic acid and the protein kinase C activator, phorbol 12-myristate 13-acetate, exerted an additive effect on p100 RasGAP induction.	Tetradecanoylphorbol Acetate	76-107	RAS p21 protein activator 1	Homo sapiens	144-150
10688643-2	2000	We found that the phorbol myristate acetate (PMA)-responsive protein kinase C (PKC) isotypes (alpha, betaI, betaII, and delta) or phosphatidylinositol-3-OH kinase (PI 3-kinase) itself activated LFA-1 to bind ICAM-1.	Tetradecanoylphorbol Acetate	18-43	integrin subunit alpha L	Homo sapiens	194-199
10688643-2	2000	We found that the phorbol myristate acetate (PMA)-responsive protein kinase C (PKC) isotypes (alpha, betaI, betaII, and delta) or phosphatidylinositol-3-OH kinase (PI 3-kinase) itself activated LFA-1 to bind ICAM-1.	Tetradecanoylphorbol Acetate	45-48	integrin subunit alpha L	Homo sapiens	194-199
10683529-4	2000	Western blot analysis with an antibody specific for phosphorylated ERK1/2 revealed that PMA, but not dBcAMP, induced phosphorylation of ERK1/2 in a time- and concentration-dependent manner.	Tetradecanoylphorbol Acetate	88-91	mitogen activated protein kinase 3	Rattus norvegicus	67-73
10683529-4	2000	Western blot analysis with an antibody specific for phosphorylated ERK1/2 revealed that PMA, but not dBcAMP, induced phosphorylation of ERK1/2 in a time- and concentration-dependent manner.	Tetradecanoylphorbol Acetate	88-91	mitogen activated protein kinase 3	Rattus norvegicus	136-142
10660591-6	2000	The time course of gastrin- and CCK-mediated ICER induction is rapid and transient, similar to forskolin- and phorbol 12-myristate 13-acetate-induced ICER expression.	Tetradecanoylphorbol Acetate	110-141	cAMP responsive element modulator	Rattus norvegicus	150-154
11263267-5	2000	In contrary, 65% or 75% EGF- or tetradecanoylphorbol acetate (TDPA, formally called PMA)--stimulated CCDPK activity and 38% or 42% [3H]thymidine incorporation treated by PDBU were inhibited, respectively.	Tetradecanoylphorbol Acetate	32-60	calcium/calmodulin-dependent protein kinase IV	Rattus norvegicus	101-106
11263267-5	2000	In contrary, 65% or 75% EGF- or tetradecanoylphorbol acetate (TDPA, formally called PMA)--stimulated CCDPK activity and 38% or 42% [3H]thymidine incorporation treated by PDBU were inhibited, respectively.	Tetradecanoylphorbol Acetate	62-66	calcium/calmodulin-dependent protein kinase IV	Rattus norvegicus	101-106
11263267-5	2000	In contrary, 65% or 75% EGF- or tetradecanoylphorbol acetate (TDPA, formally called PMA)--stimulated CCDPK activity and 38% or 42% [3H]thymidine incorporation treated by PDBU were inhibited, respectively.	Tetradecanoylphorbol Acetate	84-87	calcium/calmodulin-dependent protein kinase IV	Rattus norvegicus	101-106
10669635-0	2000	Inducible expression of manganese superoxide dismutase by phorbol 12-myristate 13-acetate is mediated by Sp1 in endothelial cells.	Tetradecanoylphorbol Acetate	58-89	superoxide dismutase [Mn], mitochondrial	Bos taurus	24-54
10669635-3	2000	In calf pulmonary artery endothelial cells, phorbol 12-myristate 13-acetate (PMA) gradually increased Mn-SOD mRNA levels, with a peak at 6 to 12 hours after stimulation.	Tetradecanoylphorbol Acetate	44-75	superoxide dismutase [Mn], mitochondrial	Bos taurus	102-108
10669635-3	2000	In calf pulmonary artery endothelial cells, phorbol 12-myristate 13-acetate (PMA) gradually increased Mn-SOD mRNA levels, with a peak at 6 to 12 hours after stimulation.	Tetradecanoylphorbol Acetate	77-80	superoxide dismutase [Mn], mitochondrial	Bos taurus	102-108
10711350-14	2000	Thapsigargin (30 nM) and TPA (30 nM) increased the levels of HDC mRNA at 4 h, but PD98059 suppressed both the thapsigargin- and TPA-induced increases in the HDC mRNA level.	Tetradecanoylphorbol Acetate	25-28	histidine decarboxylase	Mus musculus	61-64
10711350-14	2000	Thapsigargin (30 nM) and TPA (30 nM) increased the levels of HDC mRNA at 4 h, but PD98059 suppressed both the thapsigargin- and TPA-induced increases in the HDC mRNA level.	Tetradecanoylphorbol Acetate	25-28	histidine decarboxylase	Mus musculus	157-160
10711350-14	2000	Thapsigargin (30 nM) and TPA (30 nM) increased the levels of HDC mRNA at 4 h, but PD98059 suppressed both the thapsigargin- and TPA-induced increases in the HDC mRNA level.	Tetradecanoylphorbol Acetate	128-131	histidine decarboxylase	Mus musculus	157-160
10711350-16	2000	These findings indicate that thapsigargin and TPA induce histamine production in RAW 264.7 cells by increasing the level of HDC mRNA, and that both the thapsigargin- and TPA-induced histamine production are regulated largely by p44/p42 MAP kinase and partially by p38 MAP kinase.	Tetradecanoylphorbol Acetate	46-49	histidine decarboxylase	Mus musculus	124-127
10711350-16	2000	These findings indicate that thapsigargin and TPA induce histamine production in RAW 264.7 cells by increasing the level of HDC mRNA, and that both the thapsigargin- and TPA-induced histamine production are regulated largely by p44/p42 MAP kinase and partially by p38 MAP kinase.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 3	Mus musculus	228-231
10711350-16	2000	These findings indicate that thapsigargin and TPA induce histamine production in RAW 264.7 cells by increasing the level of HDC mRNA, and that both the thapsigargin- and TPA-induced histamine production are regulated largely by p44/p42 MAP kinase and partially by p38 MAP kinase.	Tetradecanoylphorbol Acetate	46-49	cyclin-dependent kinase 20	Mus musculus	232-235
10711350-16	2000	These findings indicate that thapsigargin and TPA induce histamine production in RAW 264.7 cells by increasing the level of HDC mRNA, and that both the thapsigargin- and TPA-induced histamine production are regulated largely by p44/p42 MAP kinase and partially by p38 MAP kinase.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 14	Mus musculus	264-267
10711350-16	2000	These findings indicate that thapsigargin and TPA induce histamine production in RAW 264.7 cells by increasing the level of HDC mRNA, and that both the thapsigargin- and TPA-induced histamine production are regulated largely by p44/p42 MAP kinase and partially by p38 MAP kinase.	Tetradecanoylphorbol Acetate	170-173	histidine decarboxylase	Mus musculus	124-127
10711350-16	2000	These findings indicate that thapsigargin and TPA induce histamine production in RAW 264.7 cells by increasing the level of HDC mRNA, and that both the thapsigargin- and TPA-induced histamine production are regulated largely by p44/p42 MAP kinase and partially by p38 MAP kinase.	Tetradecanoylphorbol Acetate	170-173	mitogen-activated protein kinase 3	Mus musculus	228-231
10711350-16	2000	These findings indicate that thapsigargin and TPA induce histamine production in RAW 264.7 cells by increasing the level of HDC mRNA, and that both the thapsigargin- and TPA-induced histamine production are regulated largely by p44/p42 MAP kinase and partially by p38 MAP kinase.	Tetradecanoylphorbol Acetate	170-173	cyclin-dependent kinase 20	Mus musculus	232-235
10711350-16	2000	These findings indicate that thapsigargin and TPA induce histamine production in RAW 264.7 cells by increasing the level of HDC mRNA, and that both the thapsigargin- and TPA-induced histamine production are regulated largely by p44/p42 MAP kinase and partially by p38 MAP kinase.	Tetradecanoylphorbol Acetate	170-173	mitogen-activated protein kinase 14	Mus musculus	264-267
10679825-4	2000	Parathyroid hormone further inhibited transgene activity and collagen synthesis in the presence of phorbol myristate acetate.	Tetradecanoylphorbol Acetate	99-124	parathyroid hormone	Mus musculus	0-19
10646500-7	2000	The level of PACAP mRNA peaked 3 h after stimulation and gradually returned to basal levels by 48 h. PC12 cells are known to express predominantly the hop isoform of the PAC1 receptor, which positively couples to both adenylate cyclase and phospholipase C. To determine the role of the cyclic AMP and protein kinase C pathways in PACAP gene expression, the effects of forskolin and phorbol 12-myristate 13-acetate (PMA) were then examined.	Tetradecanoylphorbol Acetate	382-413	adenylate cyclase activating polypeptide 1	Rattus norvegicus	13-18
10646501-6	2000	MMP-2 expression was constitutive and remained unchanged at both the mRNA and protein levels in response to RA, tumor necrosis factor-alpha (TNFalpha), or phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	155-186	matrix metallopeptidase 2	Homo sapiens	0-5
10949579-1	2000	Generation of the serine proteinase plasmin from the extracellular zymogen plasminogen can be catalyzed by either of two other serine proteinases, the urokinase- and tissue-type plasminogen activators (uPA and tPA).	Tetradecanoylphorbol Acetate	210-213	plasminogen	Homo sapiens	36-43
11787589-10	2000	When we added phorbol myristyl acetate (PMA) to the cell line, secretion of nitric oxide (NO) was increased 4-fold and the TAUT activity was decreased 5-fold.	Tetradecanoylphorbol Acetate	40-43	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	Mus musculus	123-127
11787589-11	2000	However, the addition of N-nitro L-arginine methyl ester (L-NAME), an inducible NO synthase (iNOS) inhibitor, to the PMA-treated cells induced recovery of TAUT activity.	Tetradecanoylphorbol Acetate	117-120	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	Mus musculus	155-159
11216470-6	2000	In the present study, we found that topical application of TPA onto dorsal skin of female ICR mice resulted in marked activation of epidermal NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	59-62	jun proto-oncogene	Mus musculus	156-160
10757128-1	2000	The study of tumor promotion in rodent carcinogenesis using chemical tumor promoters has revealed various tumor promotion pathways, such as the 12-O-tetradecanoylphorbol-13-acetate (TPA) pathway mediated through activation of protein kinase C, and the okadaic acid pathway mediated through inhibition of protein phosphatases 1 and 2A (PP-1 and PP-2A).	Tetradecanoylphorbol Acetate	182-185	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	331-333
10757128-1	2000	The study of tumor promotion in rodent carcinogenesis using chemical tumor promoters has revealed various tumor promotion pathways, such as the 12-O-tetradecanoylphorbol-13-acetate (TPA) pathway mediated through activation of protein kinase C, and the okadaic acid pathway mediated through inhibition of protein phosphatases 1 and 2A (PP-1 and PP-2A).	Tetradecanoylphorbol Acetate	182-185	protein phosphatase 1 catalytic subunit gamma	Mus musculus	335-339
10757128-1	2000	The study of tumor promotion in rodent carcinogenesis using chemical tumor promoters has revealed various tumor promotion pathways, such as the 12-O-tetradecanoylphorbol-13-acetate (TPA) pathway mediated through activation of protein kinase C, and the okadaic acid pathway mediated through inhibition of protein phosphatases 1 and 2A (PP-1 and PP-2A).	Tetradecanoylphorbol Acetate	182-185	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	344-349
10757128-2	2000	We previously demonstrated that application of TPA and okadaic acid induced tumor necrosis factor-alpha (TNF-alpha) gene expression in mouse skin, but that tautomycin, which is an inhibitor of PP-1 and PP-2A and not a tumor promoter on mouse skin, did not.	Tetradecanoylphorbol Acetate	47-50	protein phosphatase 1 catalytic subunit gamma	Mus musculus	193-197
10757128-2	2000	We previously demonstrated that application of TPA and okadaic acid induced tumor necrosis factor-alpha (TNF-alpha) gene expression in mouse skin, but that tautomycin, which is an inhibitor of PP-1 and PP-2A and not a tumor promoter on mouse skin, did not.	Tetradecanoylphorbol Acetate	47-50	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	202-207
11472441-3	2001	We have now investigated the effect of metalloproteinase inhibitors and a serine proteinase inhibitor on the shedding of Fc gamma RIIIb induced by phorbol 12-myristate 13-acetate (PMA) or cytochalasin B (cyto B) + N-formyl-methionyl-leucyl-phenylalanine (fMLP).	Tetradecanoylphorbol Acetate	180-183	Fc gamma receptor IIIb	Homo sapiens	121-135
11304541-3	2001	U937 cells are shown to respond to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce expression of histone acetylases p300 and p300/CBP-associated factor (PCAF).	Tetradecanoylphorbol Acetate	49-85	E1A binding protein p300	Homo sapiens	135-139
11304541-3	2001	U937 cells are shown to respond to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce expression of histone acetylases p300 and p300/CBP-associated factor (PCAF).	Tetradecanoylphorbol Acetate	49-85	lysine acetyltransferase 2B	Homo sapiens	144-170
11304541-3	2001	U937 cells are shown to respond to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce expression of histone acetylases p300 and p300/CBP-associated factor (PCAF).	Tetradecanoylphorbol Acetate	49-85	lysine acetyltransferase 2B	Homo sapiens	172-176
11304541-3	2001	U937 cells are shown to respond to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce expression of histone acetylases p300 and p300/CBP-associated factor (PCAF).	Tetradecanoylphorbol Acetate	87-90	E1A binding protein p300	Homo sapiens	135-139
11304541-3	2001	U937 cells are shown to respond to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce expression of histone acetylases p300 and p300/CBP-associated factor (PCAF).	Tetradecanoylphorbol Acetate	87-90	lysine acetyltransferase 2B	Homo sapiens	144-170
11304541-3	2001	U937 cells are shown to respond to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce expression of histone acetylases p300 and p300/CBP-associated factor (PCAF).	Tetradecanoylphorbol Acetate	87-90	lysine acetyltransferase 2B	Homo sapiens	172-176
11304541-5	2001	Interestingly, full-length IRF-2 in TPA-treated U937 cells occurred as a complex with p300 as well as PCAF and was itself acetylated.	Tetradecanoylphorbol Acetate	36-39	E1A binding protein p300	Homo sapiens	86-90
11304541-5	2001	Interestingly, full-length IRF-2 in TPA-treated U937 cells occurred as a complex with p300 as well as PCAF and was itself acetylated.	Tetradecanoylphorbol Acetate	36-39	lysine acetyltransferase 2B	Homo sapiens	102-106
11368535-7	2001	TPA, Con-A, and Vitrogen resulted in the up-regulation of MMP-2 in S2-020.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 2	Homo sapiens	58-63
11368535-11	2001	CONCLUSION: These data suggest that, while MMP-2 and MMP-9 are not constitutively expressed in pancreatic carcinoma cell lines, they may be up-regulated by TPA, Con-A, and Vitrogen.	Tetradecanoylphorbol Acetate	156-159	matrix metallopeptidase 2	Homo sapiens	43-48
11311487-5	2001	Immunostaining of connexin 43 (Cx43) protein in WB cells indicated that TPA caused a loss of Cx43 protein from the cell membranes.	Tetradecanoylphorbol Acetate	72-75	gap junction protein alpha 1	Homo sapiens	18-29
11311487-5	2001	Immunostaining of connexin 43 (Cx43) protein in WB cells indicated that TPA caused a loss of Cx43 protein from the cell membranes.	Tetradecanoylphorbol Acetate	72-75	gap junction protein alpha 1	Homo sapiens	31-35
11311487-5	2001	Immunostaining of connexin 43 (Cx43) protein in WB cells indicated that TPA caused a loss of Cx43 protein from the cell membranes.	Tetradecanoylphorbol Acetate	72-75	gap junction protein alpha 1	Homo sapiens	93-97
10607728-3	2000	A differential inhibition was found with N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide, a selective inhibitor of the cyclooxygenase isoenzyme COX-2: the promoting effect of TPA, but not that of TCDD, was abolished.	Tetradecanoylphorbol Acetate	179-182	cytochrome c oxidase II, mitochondrial	Mus musculus	148-153
12419948-1	2002	The effect of activins A, AB, and B on hepatocyte growth factor (HGF) synthesis stimulated by 12-O-tetradecanoylphorbol beta-acetate (TPA) was studied in MRC-5 human lung fibroblasts.	Tetradecanoylphorbol Acetate	134-137	hepatocyte growth factor	Homo sapiens	65-68
12419948-2	2002	Activins A, AB, and B inhibited the increase in HGF secretion induced by TPA in different dose-dependent manners and potencies.	Tetradecanoylphorbol Acetate	73-76	hepatocyte growth factor	Homo sapiens	48-51
11311487-8	2001	The inhibition of GJIC by TPA in WB cells was correlated with the hyperphosphorylation of Cx43 as measured by mobility shifts of the western blot bands of Cx43.	Tetradecanoylphorbol Acetate	26-29	gap junction protein alpha 1	Homo sapiens	90-94
12354113-9	2002	Indeed, in primary T-cells and Jurkat cells stimulated with the NF-kappaB inducers TNF or phorbol 12-myristate 13-acetate (PMA), TRAF4-mRNA was rapidly up-regulated.	Tetradecanoylphorbol Acetate	90-121	TNF receptor associated factor 4	Homo sapiens	129-134
11311487-8	2001	The inhibition of GJIC by TPA in WB cells was correlated with the hyperphosphorylation of Cx43 as measured by mobility shifts of the western blot bands of Cx43.	Tetradecanoylphorbol Acetate	26-29	gap junction protein alpha 1	Homo sapiens	155-159
11311487-9	2001	TPA induced hyperphosphorylation of Cx43 protein, while GeO(2) appeared to partially block this hyperphosphorylation.	Tetradecanoylphorbol Acetate	0-3	gap junction protein alpha 1	Homo sapiens	36-40
11327693-2	2001	We found that PMA-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) increased its binding with Tob that exerts an anti-proliferative effect through the binding with ErbB-2.	Tetradecanoylphorbol Acetate	14-17	myristoylated alanine rich protein kinase C substrate	Homo sapiens	45-90
11327693-2	2001	We found that PMA-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) increased its binding with Tob that exerts an anti-proliferative effect through the binding with ErbB-2.	Tetradecanoylphorbol Acetate	14-17	myristoylated alanine rich protein kinase C substrate	Homo sapiens	92-98
12354113-9	2002	Indeed, in primary T-cells and Jurkat cells stimulated with the NF-kappaB inducers TNF or phorbol 12-myristate 13-acetate (PMA), TRAF4-mRNA was rapidly up-regulated.	Tetradecanoylphorbol Acetate	123-126	TNF receptor associated factor 4	Homo sapiens	129-134
12114511-4	2002	A requirement for PKC betaII for phagocytosis was demonstrated collectively by phorbol 12-myristate 13-acetate-induced depletion of PKC betaII, by dose-response to PKC inhibitor Ro-32-0432, and by use of PKC betaII myristoylated peptide as a blocker.	Tetradecanoylphorbol Acetate	79-110	protein kinase C, beta	Mus musculus	18-21
11301042-10	2001	On the other hand, BisA and PMA both promoted PKC-dependent activation of Erk 1 and 2 in this system.	Tetradecanoylphorbol Acetate	28-31	mitogen activated protein kinase 3	Rattus norvegicus	74-85
11380624-5	2001	Similarly, TPA-induced PLD activation was reduced in Btk deficient cells, but unaffected in Lyn deficient cells.	Tetradecanoylphorbol Acetate	11-14	Bruton tyrosine kinase	Gallus gallus	53-56
12218129-2	2002	IRF-4 expression is tightly regulated in resting primary T cells and is transiently induced at the mRNA and protein levels after activation by Ag-mimetic stimuli such as TCR cross-linking or treatment with phorbol ester and calcium ionophore (PMA/ionomycin).	Tetradecanoylphorbol Acetate	243-246	interferon regulatory factor 4	Homo sapiens	0-5
11380624-6	2001	Finally, in cells deficient in the PLC-gamma2, one of the phosphorylated substrates regulated by Syk and Btk, TPA-induced PLD activation, as well as phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis was remarkably reduced.	Tetradecanoylphorbol Acetate	110-113	Bruton tyrosine kinase	Gallus gallus	105-108
11380624-7	2001	CONCLUSIONS: We demonstrated that the Syk, Btk and PLC-gamma2 pathways are required for TPA-induced PLD activation in DT40 cells.	Tetradecanoylphorbol Acetate	88-91	Bruton tyrosine kinase	Gallus gallus	43-46
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	95-120	ATP binding cassette subfamily C member 8	Homo sapiens	203-207
12077118-0	2002	Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.	Tetradecanoylphorbol Acetate	0-31	LOC100508689	Homo sapiens	82-87
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	95-120	ATP binding cassette subfamily C member 8	Homo sapiens	255-259
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	122-125	ATP binding cassette subfamily C member 8	Homo sapiens	203-207
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	122-125	ATP binding cassette subfamily C member 8	Homo sapiens	255-259
11329379-7	2001	Also, the PKC inhibitor GF109203X abolished both the LTD(4)- and the TPA-induced dissociation of vinculin from alpha-catenin.	Tetradecanoylphorbol Acetate	69-72	vinculin	Homo sapiens	97-105
12213569-7	2002	Distinct from serum factors and the tumor promoter TPA-induced MAPKs, which resulted in transcriptional activation of ELK or c-JUN, TCDD-stimulated MAPKs were critical for the induction of AHR-dependent gene transcription and CYP1A1 expression.	Tetradecanoylphorbol Acetate	51-54	aryl hydrocarbon receptor	Homo sapiens	189-192
12176893-5	2002	When PBMCs were stimulated with phorbol myristate acetate/ionomycin or with anti-CD3/anti-CD28, the accumulation of LTalpha both at mRNA and protein levels was markedly inhibited by CsA.	Tetradecanoylphorbol Acetate	32-57	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	182-185
11264247-11	2001	Pretreatment with PMA for 24 h, preincubation with a PKC inhibitor staurosporine or the tyrosine kinase inhibitors, genistein and herbimycin A for 1 h, substantially reduced [(3)H]-thymidine incorporation and p42/p44 MAPK phosphorylation induced by OX-LDL.	Tetradecanoylphorbol Acetate	18-21	mitogen activated protein kinase 3	Rattus norvegicus	213-221
11262186-7	2001	The activity of two protein tyrosine kinases, Src and FAK, was shown to be necessary and sufficient for TPA-induced Cas phosphorylation.	Tetradecanoylphorbol Acetate	104-107	protein tyrosine kinase 2	Homo sapiens	54-57
12204819-6	2002	A concentration of &gt; 0.2 nM TPA or 0.12 ng/mL (0.02 nM) EGF produced a significant increase in transformation response as well as in extracellular signal-regulated protein kinase (ERK), SRE, or AP-1 activation.	Tetradecanoylphorbol Acetate	31-34	jun proto-oncogene	Mus musculus	197-201
11124936-5	2001	In 32D cells, Rap1 was also activated by phorbol 12-myristate 13-acetate and ionomycin, which also enhanced cell adhesion to fibronectin, whereas, an inhibitor of phospholipase C, inhibited both cytokine-induced activation of Rap1 and cell adhesion.	Tetradecanoylphorbol Acetate	41-72	RAS-related protein 1a	Mus musculus	14-18
12204819-9	2002	These findings suggest that the signaling pathway leading to the activation of ERK, TCF, and AP-1 proteins constitutes a major factor determining the risk of tumor promotion by TPA or EGF.	Tetradecanoylphorbol Acetate	177-180	jun proto-oncogene	Mus musculus	93-97
11124936-5	2001	In 32D cells, Rap1 was also activated by phorbol 12-myristate 13-acetate and ionomycin, which also enhanced cell adhesion to fibronectin, whereas, an inhibitor of phospholipase C, inhibited both cytokine-induced activation of Rap1 and cell adhesion.	Tetradecanoylphorbol Acetate	41-72	RAS-related protein 1a	Mus musculus	226-230
12225365-2	2002	Phorbol 12-myristate 13-acetate (PMA) caused time- and concentration-dependent adhesion of AML cells to plated bovine serum albumin (BSA), which was blocked by anti-CD11b or anti-CD18 monoclonal antibodies (mAb) directed against beta2-integrin.	Tetradecanoylphorbol Acetate	0-31	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	229-234
11134023-4	2001	This defective inside-out integrin activation is only restricted to beta(2) integrins, since beta(1) integrins expressed in K562 readily respond to activation signals, such as phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	176-207	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	68-75
12225365-2	2002	Phorbol 12-myristate 13-acetate (PMA) caused time- and concentration-dependent adhesion of AML cells to plated bovine serum albumin (BSA), which was blocked by anti-CD11b or anti-CD18 monoclonal antibodies (mAb) directed against beta2-integrin.	Tetradecanoylphorbol Acetate	33-36	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	229-234
12204112-1	2002	Bach2 is an oxidative stress-regulated transcription factor and functions as a repressor of gene expression directed by the TPA-response element, the Maf recognition element, and the antioxidant responsive element.	Tetradecanoylphorbol Acetate	124-127	BTB and CNC homology, basic leucine zipper transcription factor 2	Mus musculus	0-5
12242039-4	2002	CgA promoter reporter plasmid experiments showed that gastrin, epidermal growth factor, and phorbol 12-myristate 13-acetate, induce upregulation of CgA after 24 h. By RT-PCR, it was found that AR42J expresses all of the five subtypes of the somatostatin (SST) receptor (SSTR) family, except SSTR4.	Tetradecanoylphorbol Acetate	92-123	chromogranin A	Rattus norvegicus	0-3
11282561-4	2001	In contrast, in peritoneal macrophages from ovalbumin-sensitized rats (sPM), IL-4 decreased cPLA2, 5-LO and FLAP expression and PMA-challenged eicosanoid production.	Tetradecanoylphorbol Acetate	128-131	interleukin 4	Rattus norvegicus	77-81
12242039-4	2002	CgA promoter reporter plasmid experiments showed that gastrin, epidermal growth factor, and phorbol 12-myristate 13-acetate, induce upregulation of CgA after 24 h. By RT-PCR, it was found that AR42J expresses all of the five subtypes of the somatostatin (SST) receptor (SSTR) family, except SSTR4.	Tetradecanoylphorbol Acetate	92-123	chromogranin A	Rattus norvegicus	148-151
11287749-2	2001	However, when cells are in suspension or in the presence of cytochalasin D which disrupts the intracellular network of actin microfilaments, TPA loses its ability to stimulate tyrosine phosphorylation of FAK and paxillin but it still activates mitogen-activated protein kinase (MAPK) and induces PKC translocation from cytosol to the membrane in HepG2 cells.	Tetradecanoylphorbol Acetate	141-144	protein tyrosine kinase 2	Homo sapiens	204-207
12110540-4	2002	Phorbol 12-myristrate 13-acetate (PMA) activated PKC-alpha and exogenous PKC-delta but not atypical PKC-lambda/zeta.	Tetradecanoylphorbol Acetate	34-37	protein kinase C delta	Homo sapiens	73-82
11287749-4	2001	Our findings suggest that TPA-induced tyrosine phosphorylation of FAK and paxillin in human hepatoma cells is PKC dependent and requires the integrity of the cell cytoskeleton but is uncoupled to the signal transduction pathway of PKC leading to the translocation of PKC and MAPK activation.	Tetradecanoylphorbol Acetate	26-29	protein tyrosine kinase 2	Homo sapiens	66-69
12115530-6	2002	TPA-stimulated expression of epidermal COX-2 and iNOS was also mitigated by topical application of the same extract.	Tetradecanoylphorbol Acetate	0-3	cytochrome c oxidase II, mitochondrial	Mus musculus	39-44
12115530-7	2002	Moreover, DA-9601 abrogated the TPA-mediated activation of NF-kappa B/Rel and AP-1 in mouse epidermis.	Tetradecanoylphorbol Acetate	32-35	jun proto-oncogene	Mus musculus	78-82
11238569-4	2001	Moreover, the NK cells from MS in remission produced much larger amounts of IL-5 than did those from controls after stimulation with phorbol myristate acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	133-158	interleukin 5	Homo sapiens	76-80
12126624-10	2002	Cells treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), known to stimulate production of H(2)O(2), showed higher levels of LEDGF mRNA.	Tetradecanoylphorbol Acetate	19-56	PC4 and SFRS1 interacting protein 1	Homo sapiens	131-136
11238569-4	2001	Moreover, the NK cells from MS in remission produced much larger amounts of IL-5 than did those from controls after stimulation with phorbol myristate acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	160-163	interleukin 5	Homo sapiens	76-80
12126624-10	2002	Cells treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), known to stimulate production of H(2)O(2), showed higher levels of LEDGF mRNA.	Tetradecanoylphorbol Acetate	58-61	PC4 and SFRS1 interacting protein 1	Homo sapiens	131-136
11267936-5	2001	Upon differentiation-induction with 12-O-tetradecanoylphorbol-13-acetate (TPA), in TTC549, showing an expression of TGF-alpha but not EGF initially, de novo expression of EGF mRNA appeared abruptly on day 2 of TPA treatment.	Tetradecanoylphorbol Acetate	36-72	transforming growth factor alpha	Homo sapiens	116-125
11267936-5	2001	Upon differentiation-induction with 12-O-tetradecanoylphorbol-13-acetate (TPA), in TTC549, showing an expression of TGF-alpha but not EGF initially, de novo expression of EGF mRNA appeared abruptly on day 2 of TPA treatment.	Tetradecanoylphorbol Acetate	74-77	transforming growth factor alpha	Homo sapiens	116-125
11267936-5	2001	Upon differentiation-induction with 12-O-tetradecanoylphorbol-13-acetate (TPA), in TTC549, showing an expression of TGF-alpha but not EGF initially, de novo expression of EGF mRNA appeared abruptly on day 2 of TPA treatment.	Tetradecanoylphorbol Acetate	210-213	transforming growth factor alpha	Homo sapiens	116-125
12070036-6	2002	These granules are positive for the matrix enzyme gelatinase and the membrane subunit of the vacuolar H(+)/ATPase and can be recruited for exocytosis by treatment of neutrophils with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	183-208	dynein axonemal heavy chain 8	Homo sapiens	36-113
11238950-5	2001	We also found that the Rac1-GTP level decreased after stimulation with TPA and that the Rac1-IQGAP1 complexes decreased, while the IQGAP1-beta-catenin complexes increased during action of TPA.	Tetradecanoylphorbol Acetate	71-74	Rac family small GTPase 1	Canis lupus familiaris	23-27
12453641-10	2002	The present study focused on the glypican-1, syndecan-1 and syndecan-4 mRNA expression and regulation under PKC activation by the phorbol myristate acetate (PMA) in 10-30 day-old Sertoli cells.	Tetradecanoylphorbol Acetate	130-155	syndecan 4	Rattus norvegicus	60-70
11215534-7	2001	In the presence of the alpha1A-adrenoceptor antagonist WB 4101 (0.1 micromol/l), which per se suppressed ventricular fibrillation to 17%, both DOG and PMA increased the occurrence of ventricular fibrillation to 73% and 75%, respectively, whereas the inactive phorbol ester 4alpha-phorbol 12,13-didecanoate (4alpha-PDD, 10 nmol/l) revealed no proarrhythmic effect.	Tetradecanoylphorbol Acetate	151-154	adrenoceptor alpha 1A	Canis lupus familiaris	23-43
12453641-10	2002	The present study focused on the glypican-1, syndecan-1 and syndecan-4 mRNA expression and regulation under PKC activation by the phorbol myristate acetate (PMA) in 10-30 day-old Sertoli cells.	Tetradecanoylphorbol Acetate	157-160	syndecan 4	Rattus norvegicus	60-70
11221892-5	2001	Although it had no manifest impact on cellularity or differentiation of skin or hair follicles, PAI-2 overexpression rendered the mice highly susceptible to skin carcinogenesis induced by a single application of 7,12-dimethylbenz(a)anthracene (initiation) followed by twice weekly applications of 12-O-tetradecanoylphorbol-13-acetate [TPA (promotion)].	Tetradecanoylphorbol Acetate	297-333	serine (or cysteine) peptidase inhibitor, clade B, member 2	Mus musculus	96-101
11221892-5	2001	Although it had no manifest impact on cellularity or differentiation of skin or hair follicles, PAI-2 overexpression rendered the mice highly susceptible to skin carcinogenesis induced by a single application of 7,12-dimethylbenz(a)anthracene (initiation) followed by twice weekly applications of 12-O-tetradecanoylphorbol-13-acetate [TPA (promotion)].	Tetradecanoylphorbol Acetate	335-338	serine (or cysteine) peptidase inhibitor, clade B, member 2	Mus musculus	96-101
12110618-9	2002	Inhibition of carbachol-induced acid secretion by TPA was accompanied by a decrease in CaMKII activity.	Tetradecanoylphorbol Acetate	50-53	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	87-93
11257453-4	2001	In contrast, 12-O-tetradecanoylphorbol-13-acetate (TPA) had no effect on the amount of Ras-GTP but led to a smaller activation of Raf-1.	Tetradecanoylphorbol Acetate	13-49	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	130-135
11257453-4	2001	In contrast, 12-O-tetradecanoylphorbol-13-acetate (TPA) had no effect on the amount of Ras-GTP but led to a smaller activation of Raf-1.	Tetradecanoylphorbol Acetate	51-54	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	130-135
10601319-1	1999	Transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA induced by a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was examined to identify the responsive transcriptional regulator.	Tetradecanoylphorbol Acetate	108-144	superoxide dismutase 2	Homo sapiens	68-73
10601319-1	1999	Transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA induced by a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was examined to identify the responsive transcriptional regulator.	Tetradecanoylphorbol Acetate	146-149	superoxide dismutase 2	Homo sapiens	36-66
10601319-1	1999	Transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA induced by a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was examined to identify the responsive transcriptional regulator.	Tetradecanoylphorbol Acetate	146-149	superoxide dismutase 2	Homo sapiens	68-73
10601319-4	1999	The region between -1292 and -1202 contains a cAMP-responsive element-like sequence, TGACGTCT, which we identified as the manganese superoxide dismutase TPA-responsive element, MSTRE.	Tetradecanoylphorbol Acetate	153-156	superoxide dismutase 2	Homo sapiens	122-152
10601319-8	1999	These results led us to conclude that the human MnSOD gene having the promoter construct used in this study is induced by TPA via activation of a CREB-1/ATF-1-like factor and not via either NF-kappaB or AP-1.	Tetradecanoylphorbol Acetate	122-125	superoxide dismutase 2	Homo sapiens	48-53
11257453-7	2001	The results identify Raf-1 as a target for both TPA- and NGF-induced signals in differentiating SH-SY5Y/TrkA cells and demonstrate that signalling to Raf-1 was mediated via distinct mechanisms.	Tetradecanoylphorbol Acetate	48-51	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	21-26
11257453-7	2001	The results identify Raf-1 as a target for both TPA- and NGF-induced signals in differentiating SH-SY5Y/TrkA cells and demonstrate that signalling to Raf-1 was mediated via distinct mechanisms.	Tetradecanoylphorbol Acetate	48-51	neurotrophic receptor tyrosine kinase 1	Homo sapiens	104-108
10601326-8	1999	Treatment of luteinized rat granulosa cells with phorbol myristate acetate, a known activator of PKC, promoted a 7-fold increase in HSP-27 phosphorylation by PKC delta.	Tetradecanoylphorbol Acetate	49-74	heat shock protein family B (small) member 1	Rattus norvegicus	132-138
12110618-11	2002	The stimulation of basal acid secretion by TPA was biphasic with a peak at a very low concentration (10 pM), resulting in an activation of the calcium-sensor CaMKII.	Tetradecanoylphorbol Acetate	43-46	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	158-164
12110618-13	2002	The TPA-induced increase of H(+) secretion was sensitive to the cell-permeable Ca(2+)-chelator BAPTA/AM, Ro 31-8220, and the CaMKII-inhibitor KN-62, but not to Go 6976.	Tetradecanoylphorbol Acetate	4-7	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	125-131
12429947-3	2002	Instead, administration of UCN-01 with PMA led to a marked increase in mitochondrial injury (e.g, cytochrome c release), activation of caspases-3 and -8, Bid cleavage, PARP degradation, and apoptosis, accompanied by a substantial reduction in viability and clonogenic survival.	Tetradecanoylphorbol Acetate	39-42	collagen type XI alpha 2 chain	Homo sapiens	168-172
11159838-5	2001	In addition, pretreatment with a PKC activator, phorbol-12-myristate 13-acetate, potentiated GnRH-induced MAPK activation.	Tetradecanoylphorbol Acetate	48-79	gonadotropin releasing hormone 1	Homo sapiens	93-97
12061815-8	2002	SB/PMA treatment also triggered a decline in the S and G(2)M populations, and dephosphorylation of p34(cdc2).	Tetradecanoylphorbol Acetate	3-6	alpha and gamma adaptin binding protein	Homo sapiens	99-102
11223466-4	2001	NGF mRNA was significantly up-regulated by phorbol ester (12-O-tetradecanoylphorbol 13-acetate, TPA) and gamma-amino-n-butyric acid (GABA) but not by hydrocortisone.	Tetradecanoylphorbol Acetate	58-94	nerve growth factor	Rattus norvegicus	0-3
10572244-9	1999	PGF(2alpha) and TPA stimulated p42/p44 mitogen-activated protein (MAP) kinase.	Tetradecanoylphorbol Acetate	16-19	cyclin-dependent kinase 20	Mus musculus	31-34
10572244-9	1999	PGF(2alpha) and TPA stimulated p42/p44 mitogen-activated protein (MAP) kinase.	Tetradecanoylphorbol Acetate	16-19	mitogen-activated protein kinase 3	Mus musculus	35-38
11223466-4	2001	NGF mRNA was significantly up-regulated by phorbol ester (12-O-tetradecanoylphorbol 13-acetate, TPA) and gamma-amino-n-butyric acid (GABA) but not by hydrocortisone.	Tetradecanoylphorbol Acetate	96-99	nerve growth factor	Rattus norvegicus	0-3
11940578-3	2002	To explore the importance of the c-Raf/MAPK kinase (MEK)/MAPK pathway, we stimulated adult feline cardiomyocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA), insulin, or forskolin to activate PKC, phosphatidylinositol-3-OH kinase, or protein kinase A (PKA), respectively.	Tetradecanoylphorbol Acetate	118-154	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	33-38
10600776-7	1999	PMA induced membrane-to-cytosol redistribution of the F-actin cross-linking protein myristoylated alanine-rich C kinase substrate (MARCKS).	Tetradecanoylphorbol Acetate	0-3	myristoylated alanine rich protein kinase C substrate	Homo sapiens	131-137
11923289-2	2002	We show here that the oxidative stress-responsive transcription factor Bach2 is a generic inhibitor of gene expression directed by the 12-O-tetradecanoylphorbol-13-acetate response element, the Maf recognition element, and the antioxidant-responsive element.	Tetradecanoylphorbol Acetate	135-171	BTB and CNC homology, basic leucine zipper transcription factor 2	Mus musculus	71-76
10683762-0	1999	ERK/MAPK pathway is required for changes of cyclin D1 and B1 during phorbol 12-myristate 13-acetate-induced differentiation of K562 cells.	Tetradecanoylphorbol Acetate	68-99	cyclin D1	Homo sapiens	44-60
10683762-3	1999	The concentrations of cyclin D1 and p21Waf1/Cip1 were dramatically increased, whereas those of cyclin B1 and cdc2 were decreased, by PMA treatment.	Tetradecanoylphorbol Acetate	133-136	cyclin D1	Homo sapiens	22-31
10683762-6	1999	Thus, it is demonstrated here that the PMA-mediated changes of cyclin D1 and B1 are the result of a persistent increase in extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) activity.	Tetradecanoylphorbol Acetate	39-42	cyclin D1	Homo sapiens	63-72
10618645-4	1999	Exploratory studies confirmed the anti-PKC effects of CalC, as equal molar concentrations of CalC blocked the PMA-induced translocation of PKC-alpha from the cytosolic to the membrane fraction.	Tetradecanoylphorbol Acetate	110-113	mitochondrial calcium uptake 1	Homo sapiens	54-58
11032837-8	2001	Phorbol myristate acetate-induced differentiation of HL-60 cells led to the parallel appearance of cib-type activity and hCNT3 mRNA.	Tetradecanoylphorbol Acetate	0-25	calcium and integrin binding 1	Homo sapiens	99-102
11032837-8	2001	Phorbol myristate acetate-induced differentiation of HL-60 cells led to the parallel appearance of cib-type activity and hCNT3 mRNA.	Tetradecanoylphorbol Acetate	0-25	solute carrier family 28 member 3	Homo sapiens	121-126
10618645-4	1999	Exploratory studies confirmed the anti-PKC effects of CalC, as equal molar concentrations of CalC blocked the PMA-induced translocation of PKC-alpha from the cytosolic to the membrane fraction.	Tetradecanoylphorbol Acetate	110-113	mitochondrial calcium uptake 1	Homo sapiens	93-97
11032837-10	2001	The hCNT3 gene mapped to chromosome 9q22.2 and included an upstream phorbol myristate acetate response element.	Tetradecanoylphorbol Acetate	68-93	solute carrier family 28 member 3	Homo sapiens	4-9
12039800-10	2002	Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate reduced junctional conductance in cells expressing Cx43, Cx45, or both connexins, but it reduced the extent of neurobiotin transfer only in HeLa-Cx43(His)(6) and HeLa-Cx43(His)(6)/Cx45 cells but not in the HeLa-Cx45 cells.	Tetradecanoylphorbol Acetate	46-82	gap junction protein alpha 1	Homo sapiens	134-138
12039800-10	2002	Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate reduced junctional conductance in cells expressing Cx43, Cx45, or both connexins, but it reduced the extent of neurobiotin transfer only in HeLa-Cx43(His)(6) and HeLa-Cx43(His)(6)/Cx45 cells but not in the HeLa-Cx45 cells.	Tetradecanoylphorbol Acetate	46-82	gap junction protein alpha 1	Homo sapiens	228-232
10567579-10	1999	Mitochondrial inhibitors, rotenone and antimycin A, reduced TPA-induced cell death in PKCdelta-overexpressing keratinocytes.	Tetradecanoylphorbol Acetate	60-63	protein kinase C delta	Homo sapiens	86-94
12039800-10	2002	Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate reduced junctional conductance in cells expressing Cx43, Cx45, or both connexins, but it reduced the extent of neurobiotin transfer only in HeLa-Cx43(His)(6) and HeLa-Cx43(His)(6)/Cx45 cells but not in the HeLa-Cx45 cells.	Tetradecanoylphorbol Acetate	46-82	gap junction protein alpha 1	Homo sapiens	228-232
11032829-4	2001	The alpha- and beta-UTR forms represent the major Gli1 transcripts expressed in mouse tissues, whereas the gamma-UTR is present at relatively low levels but is markedly induced in mouse skin treated with 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	204-240	GLI-Kruppel family member GLI1	Mus musculus	50-54
12032821-3	2002	In the present study, we report that reduction of MnSOD by heterozygous knockout of the MnSOD gene (Sod2 -/+, MnSOD KO) increased the levels of oxidative damage proteins and the activity of AP-1 following TPA treatment.	Tetradecanoylphorbol Acetate	205-208	jun proto-oncogene	Mus musculus	190-194
10569809-0	1999	Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion.	Tetradecanoylphorbol Acetate	70-106	prostaglandin-endoperoxide synthase 2	Mus musculus	170-186
12032821-12	2002	Taken together, these results suggest that: (1) MnSOD deficiency enhanced TPA-induced oxidative stress and AP-1 and p53 levels, consistent with the increase in both proliferation and apoptosis events in the MnSOD KO mice, and (2) increased apoptosis may negate increased proliferation in the MnSOD deficient mice during an early stage of tumor development.	Tetradecanoylphorbol Acetate	74-77	jun proto-oncogene	Mus musculus	107-111
11145836-4	2001	The IL-1H transcripts were stimulated by phorbol ester (PMA) in human cell lines (A431, THP-1 and KG-1) and peripheral blood mononuclear cells (HPBMC) and dendritic cells (NHDC).	Tetradecanoylphorbol Acetate	56-59	interleukin 37	Homo sapiens	4-9
11880362-7	2002	Second, treatment of U937 cells with TPA significantly increased (3-5-fold) hMSH2 expression and, to a lesser extent, hMSH6 and hPMS2 expression, correlated to a restoration of MMR function.	Tetradecanoylphorbol Acetate	37-40	mutS homolog 2	Homo sapiens	76-81
11988078-8	2002	The cirazoline-stimulated (alpha(1)-adrenergic) CREB phosphorylation was inhibited by a desensitizing pretreatment with PMA, demonstrating that the alpha(1)-stimulation was mediated via protein kinase C activation; neither Src nor extracellular-signal-regulated kinases 1 and 2 activation was involved in the signalling process.	Tetradecanoylphorbol Acetate	120-123	mitogen-activated protein kinase 3	Mus musculus	231-277
11231886-4	2001	Topical application of curcumin was reported to inhibit TPA-induced c-fos, c-jun and c-myc gene expression in mouse skin.	Tetradecanoylphorbol Acetate	56-59	jun proto-oncogene	Mus musculus	75-80
11231886-8	2001	CONCLUSIONS: Whereas earlier work demonstrated that topical application of curcumin to mouse skin inhibited TPA-induced expression of c-fos, c-jun and c-myc oncogenes, our results are the first to show that orally consumed curcumin significantly inhibited DMBA- and TPA-induced ras and fos gene expression in mouse skin.	Tetradecanoylphorbol Acetate	108-111	jun proto-oncogene	Mus musculus	141-146
10535756-1	1999	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can induce expression of many immediate-early genes, such as c-fos and c-jun.	Tetradecanoylphorbol Acetate	19-55	jun proto-oncogene	Mus musculus	133-138
10535756-1	1999	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can induce expression of many immediate-early genes, such as c-fos and c-jun.	Tetradecanoylphorbol Acetate	57-60	jun proto-oncogene	Mus musculus	133-138
10634965-3	1999	METHODS: Basal, concanavalin A (Con A)-, and phorbol-12-myristate-13-acetate (PMA)-stimulated lymphocyte PC-1, aminopeptidase N (APN), and dipeptidylpeptidase IV (DPP IV) activities were determined in 16 patients with Type 2 diabetes before and after 3 months of metformin treatment.	Tetradecanoylphorbol Acetate	45-76	alanyl aminopeptidase, membrane	Homo sapiens	111-127
10634965-3	1999	METHODS: Basal, concanavalin A (Con A)-, and phorbol-12-myristate-13-acetate (PMA)-stimulated lymphocyte PC-1, aminopeptidase N (APN), and dipeptidylpeptidase IV (DPP IV) activities were determined in 16 patients with Type 2 diabetes before and after 3 months of metformin treatment.	Tetradecanoylphorbol Acetate	45-76	alanyl aminopeptidase, membrane	Homo sapiens	129-132
10634965-3	1999	METHODS: Basal, concanavalin A (Con A)-, and phorbol-12-myristate-13-acetate (PMA)-stimulated lymphocyte PC-1, aminopeptidase N (APN), and dipeptidylpeptidase IV (DPP IV) activities were determined in 16 patients with Type 2 diabetes before and after 3 months of metformin treatment.	Tetradecanoylphorbol Acetate	78-81	alanyl aminopeptidase, membrane	Homo sapiens	129-132
12148241-1	2002	By means of cryo-scanning electron microscopy (cryo-SEM) and fluorescent techniques, evidence is provided on how 12-O-tetradecanoylphorbol-13-acetate (TPA) affects Sertoli cell morphology and F-actin and vinculin organization in vitro.	Tetradecanoylphorbol Acetate	113-149	vinculin	Homo sapiens	204-212
10523856-3	1999	Downstream of protein kinase C (PKC), the effects of TPA are often mediated by the Raf-1/MEK/ERK mitogen-activated protein kinase (MAPK) cascade, and Raf-1 has been implicated in MDR1 induction by serum and mitogens.	Tetradecanoylphorbol Acetate	53-56	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	83-88
10523856-3	1999	Downstream of protein kinase C (PKC), the effects of TPA are often mediated by the Raf-1/MEK/ERK mitogen-activated protein kinase (MAPK) cascade, and Raf-1 has been implicated in MDR1 induction by serum and mitogens.	Tetradecanoylphorbol Acetate	53-56	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	150-155
10523856-8	1999	TPA also activated the Raf1/MEK/ERK cascade and activated another MAPK member, p38, but not JNK.	Tetradecanoylphorbol Acetate	0-3	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	23-27
11824471-8	2001	Activation of PKC by phorbol ester (PMA) resulted in a decrease in ECM protein deposition and an increase in MMP-2 secretion.	Tetradecanoylphorbol Acetate	36-39	matrix metallopeptidase 2	Rattus norvegicus	109-114
10512355-8	1999	In contrast, TPA translocated GLUT1 and GLUT3 without affecting GLUT4.	Tetradecanoylphorbol Acetate	13-16	solute carrier family 2 member 1	Rattus norvegicus	30-35
12148241-1	2002	By means of cryo-scanning electron microscopy (cryo-SEM) and fluorescent techniques, evidence is provided on how 12-O-tetradecanoylphorbol-13-acetate (TPA) affects Sertoli cell morphology and F-actin and vinculin organization in vitro.	Tetradecanoylphorbol Acetate	151-154	vinculin	Homo sapiens	204-212
11824476-9	2001	Activation of PKC by phorbol ester (PMA) resulted in a decrease in ECM protein deposition and an increase in MMP-2 secretion.	Tetradecanoylphorbol Acetate	36-39	matrix metallopeptidase 2	Rattus norvegicus	109-114
12148241-6	2002	Thus, the reorganization of actin and vinculin and subsequent changes in cell morphology seem to be brought about by TPA affecting not only actin but also the protein vinculin which interacts with actin.	Tetradecanoylphorbol Acetate	117-120	vinculin	Homo sapiens	38-46
10506935-7	1999	In this review, we present a two-dimensional motility assay as a cohort migration model, in which human colorectal carcinoma cells move outwards from the cell islands mainly as localized coherent sheets of cells when stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) or hepatocyte growth factor/scatter factor (HGF/SF).	Tetradecanoylphorbol Acetate	233-269	hepatocyte growth factor	Homo sapiens	320-326
12148241-6	2002	Thus, the reorganization of actin and vinculin and subsequent changes in cell morphology seem to be brought about by TPA affecting not only actin but also the protein vinculin which interacts with actin.	Tetradecanoylphorbol Acetate	117-120	vinculin	Homo sapiens	167-175
10506935-9	1999	This localized modulation of cell-cell adhesion at the lower portion of the cells is associated with increased tyrosine phosphorylation of the E-cadherin-catenin complex in TPA-induced cohort migration and with reduced alpha-catenin complexed with E-cadherin in HGF/SF-induced cohort migration.	Tetradecanoylphorbol Acetate	173-176	hepatocyte growth factor	Homo sapiens	262-268
11104682-5	2000	In view of the slower kinetics of PMA-induced RGS16 expression and the tight correlation between TNFalpha and RGS16 mRNA induction among the cell lines studied, we suggest that activation of PKC up-regulates RGS16 via TNFalpha.	Tetradecanoylphorbol Acetate	34-37	regulator of G protein signaling 16	Homo sapiens	46-51
10504298-7	1999	Compared to TPA-treated wild-type mice, the epidermis of TPA-treated K5-PKCalpha mice displayed increased expression of cyclooxygenase-2 (COX-2), the neutrophil chemotactic factor macrophage inflammatory protein-2 (MIP-2) mRNA and the proinflammatory cytokine TNFalpha mRNA but not IL-6 or IL-1alpha mRNA.	Tetradecanoylphorbol Acetate	57-60	prostaglandin-endoperoxide synthase 2	Mus musculus	120-136
11980644-3	2002	Inhibition of the histone acetyltransferase activity of CREB- binding protein (CBP)/p300 blocked the induction of COX-2 by PMA.	Tetradecanoylphorbol Acetate	123-126	E1A binding protein p300	Homo sapiens	84-88
10504298-7	1999	Compared to TPA-treated wild-type mice, the epidermis of TPA-treated K5-PKCalpha mice displayed increased expression of cyclooxygenase-2 (COX-2), the neutrophil chemotactic factor macrophage inflammatory protein-2 (MIP-2) mRNA and the proinflammatory cytokine TNFalpha mRNA but not IL-6 or IL-1alpha mRNA.	Tetradecanoylphorbol Acetate	57-60	prostaglandin-endoperoxide synthase 2	Mus musculus	138-143
11120776-6	2000	MBL binding to polymorphonuclear leukocytes (PMNs) was associated positively with changes in CR1 expression induced by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	119-144	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	93-96
11961080-5	2002	The IC(50) for IL-5 and IL-13 in TPA/ionomycin-stimulated peripheral blood mononuclear cells (PBMC) is 0.7 +/- 0.1 and 0.5 +/- 0.1 microM, respectively, whereas the IC(50) for IFN-gamma is 2.0 +/- 0.4 microM.	Tetradecanoylphorbol Acetate	33-36	interleukin 5	Homo sapiens	15-19
10995778-8	2000	Induction of SAA by phorbol 12-myristate 13-acetate, a known agonist of protein kinase C (PKC), suggested a potential role of the PKC signaling pathway in the activation process.	Tetradecanoylphorbol Acetate	20-51	protein kinase C beta	Homo sapiens	90-93
10471314-4	1999	We show that 13-8300 can detect several phosphorylated species of connexin43 in Western blots after stimulation of two fibroblast cell systems with fresh growth medium, 12-O-tetradecanoyl phorbol-13-acetate, pervanadate, or permolybdate.	Tetradecanoylphorbol Acetate	169-206	gap junction protein alpha 1	Homo sapiens	66-76
10469622-0	1999	Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters.	Tetradecanoylphorbol Acetate	91-94	peroxiredoxin 5	Mus musculus	26-47
10469622-2	1999	The specific activity of thioredoxin and thioredoxin reductase in extracts from normal epidermis increased by 40 and 50%, respectively, after single or multiple application of TPA.	Tetradecanoylphorbol Acetate	176-179	peroxiredoxin 5	Mus musculus	41-62
10995778-8	2000	Induction of SAA by phorbol 12-myristate 13-acetate, a known agonist of protein kinase C (PKC), suggested a potential role of the PKC signaling pathway in the activation process.	Tetradecanoylphorbol Acetate	20-51	protein kinase C beta	Homo sapiens	130-133
12069074-3	2002	When a human myelomonocytic cell line U937 was treated with phorbol 12-myristate 13-acetate for 3 days, the LPS-induced MAIL expression was much potentiated in parallel with an increase in TLR4 expression.	Tetradecanoylphorbol Acetate	60-91	NFKB inhibitor zeta	Homo sapiens	120-124
11156386-5	2000	Epiregulin existed as highly glycosylated membrane-bound forms, and TPA rapidly induced ectodomain shedding of epiregulin.	Tetradecanoylphorbol Acetate	68-71	epiregulin	Homo sapiens	111-121
10469622-8	1999	Induction of thioredoxin, thioredoxin reductase and glutaredoxin activities by TPA and calcium ionophores may play a general role in the epigenetic mechanism of tumor promotion via thiol redox control mechanisms.	Tetradecanoylphorbol Acetate	79-82	peroxiredoxin 5	Mus musculus	26-47
10464057-5	1999	Following stimulation with PMA, a decrease in the proportion of PMN expressing CD69 at high levels was observed in elderly compared with young subjects (young, 55.3%; elderly, 43.9%; P=0.01).	Tetradecanoylphorbol Acetate	27-30	CD69 molecule	Homo sapiens	79-83
11779859-4	2002	Overexpression of a glutathione S-transferase/MT1-MMP fusion protein containing the transmembrane and cytoplasmic domains of MT1-MMP inhibited the phorbol 12-myristate 13-acetate-induced autocatalytic cleavage of endogenous MT1-MMP to the 43-kDa species, but not proMMP-2 activation.	Tetradecanoylphorbol Acetate	147-178	matrix metallopeptidase 14	Homo sapiens	46-53
11779859-4	2002	Overexpression of a glutathione S-transferase/MT1-MMP fusion protein containing the transmembrane and cytoplasmic domains of MT1-MMP inhibited the phorbol 12-myristate 13-acetate-induced autocatalytic cleavage of endogenous MT1-MMP to the 43-kDa species, but not proMMP-2 activation.	Tetradecanoylphorbol Acetate	147-178	matrix metallopeptidase 14	Homo sapiens	125-132
10412048-9	1999	12-O-Tetradecanoylphorbol-13-acetate, an activator of PKC, attenuated the phosphorylation of p38 MAP kinase by bFGF, but did not affect the A23187-induced phosphorylation.	Tetradecanoylphorbol Acetate	0-36	mitogen-activated protein kinase 14	Mus musculus	93-96
11779859-4	2002	Overexpression of a glutathione S-transferase/MT1-MMP fusion protein containing the transmembrane and cytoplasmic domains of MT1-MMP inhibited the phorbol 12-myristate 13-acetate-induced autocatalytic cleavage of endogenous MT1-MMP to the 43-kDa species, but not proMMP-2 activation.	Tetradecanoylphorbol Acetate	147-178	matrix metallopeptidase 14	Homo sapiens	125-132
10412048-9	1999	12-O-Tetradecanoylphorbol-13-acetate, an activator of PKC, attenuated the phosphorylation of p38 MAP kinase by bFGF, but did not affect the A23187-induced phosphorylation.	Tetradecanoylphorbol Acetate	0-36	fibroblast growth factor 2	Mus musculus	111-115
12058867-6	2002	1alpha25(OH)2D3 interfered with RA inhibition of the TPA-response element binding activity of AP-1 in the cytokine-treated cells.	Tetradecanoylphorbol Acetate	53-56	jun proto-oncogene	Mus musculus	94-98
10461889-4	1999	ET-induced COX2 mRNA expression was suppressed by 5 microg/ml actinomycin D, 30 microM BAPTA/AM, inhibitors of protein kinase C (1-100 nM staurosporin and 100 microM H-7), 2 microM dexamethasone, and prolonged treatment with 100 nM phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	232-263	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	11-15
11167759-4	2000	We report high expression of CTAP III in mature human bone marrow (BM) MKs and megakaryoblast cell lines following differentiation induction with phorbol ester 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	185-188	pro-platelet basic protein	Homo sapiens	29-37
11118039-3	2000	Western analysis showed that expression of NEP and protein kinase Cdelta (PKCdelta) correlated with PC cell sensitivity to TPA-induced growth arrest and apoptosis in LNCaP cells and in TSU-Prl cells expressing an inducible wild-type NEP protein.	Tetradecanoylphorbol Acetate	123-126	protein kinase C delta	Homo sapiens	51-72
11118039-3	2000	Western analysis showed that expression of NEP and protein kinase Cdelta (PKCdelta) correlated with PC cell sensitivity to TPA-induced growth arrest and apoptosis in LNCaP cells and in TSU-Prl cells expressing an inducible wild-type NEP protein.	Tetradecanoylphorbol Acetate	123-126	protein kinase C delta	Homo sapiens	74-82
11118039-4	2000	Inhibition of NEP enzyme activity using the specific NEP inhibitor CGS24592, or inhibition of PKCdelta using Rottlerin at concentrations that inhibit PKCdelta but not PKCalpha, significantly inhibited TPA-induced growth inhibition and cell death.	Tetradecanoylphorbol Acetate	201-204	protein kinase C delta	Homo sapiens	94-102
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	0-3	midkine	Mus musculus	24-27
11118039-4	2000	Inhibition of NEP enzyme activity using the specific NEP inhibitor CGS24592, or inhibition of PKCdelta using Rottlerin at concentrations that inhibit PKCdelta but not PKCalpha, significantly inhibited TPA-induced growth inhibition and cell death.	Tetradecanoylphorbol Acetate	201-204	protein kinase C delta	Homo sapiens	150-158
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	260-263	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	202-206
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	381-384	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	202-206
11108278-5	2000	High levels of glucose (i.e. 25 mM) and phorbol 12-myristate 13-acetate (PMA; 10(-7) M) increased the secretion of IR-rANG and cellular ANG messenger RNA as well as phosphorylation of p38 MAPK in IRPTCs.	Tetradecanoylphorbol Acetate	40-71	mitogen activated protein kinase 14	Rattus norvegicus	184-192
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	0-3	midkine	Mus musculus	94-97
11108278-5	2000	High levels of glucose (i.e. 25 mM) and phorbol 12-myristate 13-acetate (PMA; 10(-7) M) increased the secretion of IR-rANG and cellular ANG messenger RNA as well as phosphorylation of p38 MAPK in IRPTCs.	Tetradecanoylphorbol Acetate	73-76	mitogen activated protein kinase 14	Rattus norvegicus	184-192
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	0-3	midkine	Mus musculus	94-97
10446305-3	1999	In the present study, the transport of succinate in Xenopus oocytes expressing NaDC-1 was inhibited up to 95% by two activators of protein kinase C, phorbol 12-myristate, 13-acetate (PMA) and sn-1, 2-dioctanoylglycerol (DOG).	Tetradecanoylphorbol Acetate	183-186	solute carrier family 13 member 2L homeolog	Xenopus laevis	79-85
10446305-5	1999	The inhibition of NaDC-1 transport by PMA was dose-dependent, and could be prevented by incubation of the oocytes with staurosporine.	Tetradecanoylphorbol Acetate	38-41	solute carrier family 13 member 2L homeolog	Xenopus laevis	18-24
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	41-44	midkine	Mus musculus	24-27
11094104-4	2000	RESULTS: Pretreatment of T cells with IFN-beta potentiates the production of IL-10 when they interact with adult human microglia, human fetal microglia, or U937 cells treated with phorbol-12-myristate-13-acetate (PMA) and IFN-gamma.	Tetradecanoylphorbol Acetate	180-211	interferon beta 1	Homo sapiens	38-46
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	41-44	midkine	Mus musculus	94-97
10580739-8	1999	Both tetradecanoyl phorbol acetate (TPA), and forskolin increased PTH-rP mRNA levels and the PTH-rP production in amnion cells, and the effect of TPA was much greater than that of forskolin.	Tetradecanoylphorbol Acetate	5-34	parathyroid hormone like hormone	Homo sapiens	66-72
10580739-8	1999	Both tetradecanoyl phorbol acetate (TPA), and forskolin increased PTH-rP mRNA levels and the PTH-rP production in amnion cells, and the effect of TPA was much greater than that of forskolin.	Tetradecanoylphorbol Acetate	5-34	parathyroid hormone like hormone	Homo sapiens	93-99
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	41-44	midkine	Mus musculus	94-97
10580739-8	1999	Both tetradecanoyl phorbol acetate (TPA), and forskolin increased PTH-rP mRNA levels and the PTH-rP production in amnion cells, and the effect of TPA was much greater than that of forskolin.	Tetradecanoylphorbol Acetate	36-39	parathyroid hormone like hormone	Homo sapiens	66-72
10580739-8	1999	Both tetradecanoyl phorbol acetate (TPA), and forskolin increased PTH-rP mRNA levels and the PTH-rP production in amnion cells, and the effect of TPA was much greater than that of forskolin.	Tetradecanoylphorbol Acetate	36-39	parathyroid hormone like hormone	Homo sapiens	93-99
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	41-44	midkine	Mus musculus	24-27
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	41-44	midkine	Mus musculus	94-97
11020456-7	2000	The stimulating effect of okadaic acid on HGF production was synergistic with that of phorbol 12-myristate 13-acetate (PMA) and epidermal growth factor (EGF), whereas it was additive to the effect of cholera toxin.	Tetradecanoylphorbol Acetate	119-122	hepatocyte growth factor	Homo sapiens	42-45
11841924-4	2002	PMA also phosphorylated MEK and ERK, and PMA-induced GATA-4 phosphorylation was blocked by an MEK inhibitor, PD98059, suggesting that PMA phosphorylates GATA-4 via the MEK-ERK pathway.	Tetradecanoylphorbol Acetate	41-44	midkine	Mus musculus	94-97
10452527-2	1999	However, direct stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) results in increased Na+,K+-ATPase.	Tetradecanoylphorbol Acetate	38-69	protein kinase C beta	Homo sapiens	31-34
10452527-2	1999	However, direct stimulation of PKC by phorbol 12-myristate 13-acetate (PMA) results in increased Na+,K+-ATPase.	Tetradecanoylphorbol Acetate	71-74	protein kinase C beta	Homo sapiens	31-34
11882609-8	2002	Stimulation of PKC by other means, such as phorbol-12-myristate-13-acetate or carbachol, also resulted in the redistribution of fluorescence in a manner similar to that observed for angiotensin II.	Tetradecanoylphorbol Acetate	43-74	protein kinase C beta	Homo sapiens	15-18
10452527-6	1999	Thus, PMA-dependent stimulation of Na+,K+-ATPase is mediated by activation of PKC-beta, whereas inhibition by DA requires activation of PKC-zeta.	Tetradecanoylphorbol Acetate	6-9	protein kinase C beta	Homo sapiens	78-86
10397721-4	1999	PTP-RO mRNA and protein expression are upregulated upon phorbol 12-myristate 13-acetate (PMA) treatment of the megakaryocytic cell lines CMS, CMK, and Dami.	Tetradecanoylphorbol Acetate	56-87	protein tyrosine phosphatase receptor type U	Homo sapiens	0-6
10397721-4	1999	PTP-RO mRNA and protein expression are upregulated upon phorbol 12-myristate 13-acetate (PMA) treatment of the megakaryocytic cell lines CMS, CMK, and Dami.	Tetradecanoylphorbol Acetate	89-92	protein tyrosine phosphatase receptor type U	Homo sapiens	0-6
11056390-3	2000	When human polymorphonuclear leukocytes (PMNs) were stimulated with phorbol myristate acetate (PMA), p40(phox) was translocated to the membrane along with p67(phox), and not was released into the cytosol.	Tetradecanoylphorbol Acetate	68-93	interleukin 9	Homo sapiens	101-104
11056390-3	2000	When human polymorphonuclear leukocytes (PMNs) were stimulated with phorbol myristate acetate (PMA), p40(phox) was translocated to the membrane along with p67(phox), and not was released into the cytosol.	Tetradecanoylphorbol Acetate	68-93	interleukin 9	Homo sapiens	105-109
11138725-5	2000	Furthermore, TAS-301 inhibited PDGF-induced activation of protein kinase C (PKC) and the phorbol 12-myristate 13-acetate-mediated induction of activator protein 1 (AP-1) in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	89-120	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	143-162
11801529-0	2002	Expression of toll-like receptors 2 and 4 and CD14 during differentiation of HL-60 cells induced by phorbol 12-myristate 13-acetate and 1 alpha, 25-dihydroxy-vitamin D(3).	Tetradecanoylphorbol Acetate	100-131	CD14 molecule	Homo sapiens	46-50
11138725-5	2000	Furthermore, TAS-301 inhibited PDGF-induced activation of protein kinase C (PKC) and the phorbol 12-myristate 13-acetate-mediated induction of activator protein 1 (AP-1) in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	89-120	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	164-168
12611484-6	2002	Collagen and phorbol ester (PMA)-evoked vesiculation was diminished in the presence of 5-(N-ethyl-N-isopropyl amiloride) (EIPA, inhibitor of NHE) or GF 109203X (inhibitor of protein kinase C).	Tetradecanoylphorbol Acetate	28-31	solute carrier family 9 member C1	Homo sapiens	141-144
11063344-8	2000	In CD28-independent activation models (e.g., stimulation with phorbol myristate acetate plus ionomycin), however, cytokine secretion was not inhibited.	Tetradecanoylphorbol Acetate	62-87	CD28 molecule	Homo sapiens	3-7
12201673-7	2002	Furthermore, both compounds inhibited the TPA-induced expression of cyclooxygenase-2 at both transcriptional and translational levels.	Tetradecanoylphorbol Acetate	42-45	prostaglandin-endoperoxide synthase 2	Mus musculus	68-84
11043541-0	2000	12-O-tetradecanoyl-phorbol-13-acetate down-regulates the Huntingtin promoter at Sp1 sites.	Tetradecanoylphorbol Acetate	0-37	huntingtin	Homo sapiens	57-67
11728381-0	2001	Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated CYP1A1 and CYP1B1 induction by 12-O-tetradecanoylphorbol-13-acetate: role of transforming growth factor beta and mitogen-activated protein kinases.	Tetradecanoylphorbol Acetate	98-134	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	78-84
10993214-4	2000	Although translocation of p47phox and p67phox to the membrane fraction by PMA-stimulation of intact and GCSF-treated neutrophils occurred in parallel with O2- production, that of CB-treated neutrophils by PMA-stimulation was not always proportional to O2- production.	Tetradecanoylphorbol Acetate	74-77	neutrophil cytosolic factor 2	Homo sapiens	38-45
10993217-3	2000	The dissociation constants (Kd"s) of TPA to PDI, histone H1 and PKCalpha were determined to be 1.03 x 10(-6) M, 5.70 x 10(-7) M, and 4.00 x 10(-7) m, respectively, by the surface plasmon resonance (SPR) method.	Tetradecanoylphorbol Acetate	37-40	prolyl 4-hydroxylase subunit beta	Homo sapiens	44-47
11728381-3	2001	Exposure of the immortalized human breast epithelial cell line MCF10A-Neo to TPA at the time of, or up to 12 hr prior to, the addition of TCDD strongly suppressed the transcriptional activation of CYP1A1 and CYP1B1 (IC(50) approximately 0.5 nM).	Tetradecanoylphorbol Acetate	77-80	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	208-214
10993217-4	2000	TPA moderately inhibited PDI activity assessed in terms of reactivation of denatured RNase A.	Tetradecanoylphorbol Acetate	0-3	prolyl 4-hydroxylase subunit beta	Homo sapiens	25-28
11707282-4	2001	On the other hand, PKCbeta inhibition suppressed the TPA-stimulated increase in neuropeptide Y mRNA, activation of neuropeptide Y gene promoter elements, and phosphorylation of Erk1/2.	Tetradecanoylphorbol Acetate	53-56	protein kinase C beta	Homo sapiens	19-26
10938388-0	2000	Phorbol 12-myristate 13-acetate induces alteration in mucin gene expression and biological properties of colon cancer cells.	Tetradecanoylphorbol Acetate	0-31	LOC100508689	Homo sapiens	54-59
11602666-5	2001	In contrast, the PKC activator phorbol-12-myristate-13-acetate (PMA) suppressed the uptake mediated by rat oatp1 and oatp2 in a concentration- and time-dependent manner.	Tetradecanoylphorbol Acetate	31-62	solute carrier organic anion transporter family, member 1a4	Rattus norvegicus	117-122
11602666-5	2001	In contrast, the PKC activator phorbol-12-myristate-13-acetate (PMA) suppressed the uptake mediated by rat oatp1 and oatp2 in a concentration- and time-dependent manner.	Tetradecanoylphorbol Acetate	64-67	solute carrier organic anion transporter family, member 1a4	Rattus norvegicus	117-122
11595128-3	2001	Coincident with the increased sensitivity of MCF-7 cells to be growth arrested by the protein kinase C (PKC) activator PMA, PMA induced 9-fold higher levels of the cyclin dependent kinase (Cdk) inhibitor p21(WAF1/GIP1) in MCF-7 compared to MDA-MB 231 cells.	Tetradecanoylphorbol Acetate	119-122	protein kinase C delta	Homo sapiens	104-107
11000026-1	2000	An ethyl acetate-soluble extract of the combined leaves and twigs of Thuja occidentalis was found to inhibit 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) in cultured mouse epidermal ME 308 cells.	Tetradecanoylphorbol Acetate	109-145	ornithine decarboxylase 1	Homo sapiens	160-183
11000026-1	2000	An ethyl acetate-soluble extract of the combined leaves and twigs of Thuja occidentalis was found to inhibit 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) in cultured mouse epidermal ME 308 cells.	Tetradecanoylphorbol Acetate	147-150	ornithine decarboxylase 1	Homo sapiens	160-183
11502742-4	2001	Phorbol 12-myristate 13-acetate and 1,2-dioctanoylglycerol induced the rapid phosphorylation of occludin in Madin-Darby canine kidney cells cultured in low extracellular calcium medium with a concomitant translocation of occludin to the regions of cell-cell contact.	Tetradecanoylphorbol Acetate	0-31	occludin	Canis lupus familiaris	96-104
11020242-4	2000	Transgenic mice that constitutively express interstitial collagenase within the epidermis of the skin have an increased susceptibility to tumorigenesis and produced tumors at lower doses of TPA as compared with wild-type mice.	Tetradecanoylphorbol Acetate	190-193	matrix metallopeptidase 13	Mus musculus	44-68
11502742-4	2001	Phorbol 12-myristate 13-acetate and 1,2-dioctanoylglycerol induced the rapid phosphorylation of occludin in Madin-Darby canine kidney cells cultured in low extracellular calcium medium with a concomitant translocation of occludin to the regions of cell-cell contact.	Tetradecanoylphorbol Acetate	0-31	occludin	Canis lupus familiaris	221-229
10951587-4	2000	Moreover, stable overexpression of PKCbeta in TUR cells reconstituted sensitivity to TPA-induced cytochrome c release and activation of caspase-3.	Tetradecanoylphorbol Acetate	85-88	protein kinase C beta	Homo sapiens	35-42
11706946-3	2001	Treatment of the SCC-25 and HSC-3 cells with phorbol 12-myristate 13-acetate (10 nmol/L) up-regulated MMP-20 mRNA and protein expression by up to 1.6-fold, but transforming growth factor beta (10 ng/mL) had no effect.	Tetradecanoylphorbol Acetate	45-76	matrix metallopeptidase 20	Homo sapiens	102-108
10951587-7	2000	These findings demonstrate that TPA induces cytochrome c release by a PKCbeta-dependent mechanism and that activation of caspase-mediated signaling is required for induction of the differentiated monocytic phenotype.	Tetradecanoylphorbol Acetate	32-35	protein kinase C beta	Homo sapiens	70-77
10926560-6	2000	The Ras inhibitor farnesyltransferase inhibitor III (100 microM for 3 h) completely abolished PMA-induced Raf-1 activation.	Tetradecanoylphorbol Acetate	94-97	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	106-111
11451947-2	2001	We previously reported that a potent protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate, increases human cystatin A expression by the activation of AP-1 proteins.	Tetradecanoylphorbol Acetate	65-101	cystatin A	Homo sapiens	119-129
10947068-6	2000	Furthermore, inhibition of TNF-alpha/beta and IL-1alpha/beta, together with CD40 ligand, failed to inhibit EC activation by resting T cells and only inhibited the response to PMA- and ionomycin-activated T cells by 40 +/- 18%.	Tetradecanoylphorbol Acetate	175-178	CD40 molecule	Homo sapiens	76-80
10922477-1	2000	Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130.	Tetradecanoylphorbol Acetate	90-93	suppressor of cytokine signaling 3	Homo sapiens	305-339
11477066-7	2001	In intact or permeabilized cells MARCKS phosphorylation increased upon stimulation with 10(-7) m phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	97-128	myristoylated alanine rich protein kinase C substrate	Homo sapiens	33-39
11423533-9	2001	Finally, both transient transfection analysis and gel mobility shift assay revealed that the AhRR gene is up-regulated by a p65/p50 heterodimer that binds to the NF-kappaB site when the cells has been exposed to 12-O-tetradecanoylphorbol-13-acetate, and this inducible expression was further enhanced by cotreatment of 12-O-tetradecanoylphorbol-13-acetate and 3-methylcholanthrene.	Tetradecanoylphorbol Acetate	212-248	aryl hydrocarbon receptor repressor	Homo sapiens	93-97
10892866-10	2000	Cells exposed to PMA (10 nM, 1 hour) yielded an additional band corresponding to a 44-kDa form of phosphorylated connexin43 and showed a decrease in the intensity of the band corresponding to the nonphosphorylated protein and an increase in the intensity of the 47-kDa band.	Tetradecanoylphorbol Acetate	17-20	gap junction protein alpha 1	Bos taurus	113-123
11423533-9	2001	Finally, both transient transfection analysis and gel mobility shift assay revealed that the AhRR gene is up-regulated by a p65/p50 heterodimer that binds to the NF-kappaB site when the cells has been exposed to 12-O-tetradecanoylphorbol-13-acetate, and this inducible expression was further enhanced by cotreatment of 12-O-tetradecanoylphorbol-13-acetate and 3-methylcholanthrene.	Tetradecanoylphorbol Acetate	212-248	RELA proto-oncogene, NF-kB subunit	Homo sapiens	124-127
10866321-5	2000	In a transient transfection assay, all three RAR subtypes, RARalpha, RARbeta, and RARgamma, could effectively inhibit phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity and the activity of oncogenes c-Jun and c-Fos on AP-1 containing reporter genes in the presence of retinoic acid (RA).	Tetradecanoylphorbol Acetate	132-168	retinoic acid receptor gamma	Homo sapiens	82-90
11423533-9	2001	Finally, both transient transfection analysis and gel mobility shift assay revealed that the AhRR gene is up-regulated by a p65/p50 heterodimer that binds to the NF-kappaB site when the cells has been exposed to 12-O-tetradecanoylphorbol-13-acetate, and this inducible expression was further enhanced by cotreatment of 12-O-tetradecanoylphorbol-13-acetate and 3-methylcholanthrene.	Tetradecanoylphorbol Acetate	319-355	aryl hydrocarbon receptor repressor	Homo sapiens	93-97
11423533-9	2001	Finally, both transient transfection analysis and gel mobility shift assay revealed that the AhRR gene is up-regulated by a p65/p50 heterodimer that binds to the NF-kappaB site when the cells has been exposed to 12-O-tetradecanoylphorbol-13-acetate, and this inducible expression was further enhanced by cotreatment of 12-O-tetradecanoylphorbol-13-acetate and 3-methylcholanthrene.	Tetradecanoylphorbol Acetate	319-355	RELA proto-oncogene, NF-kB subunit	Homo sapiens	124-127
11443050-3	2001	In neutrophilic HL60 cells, the PKC activator phorbol myristate acetate (PMA) activates multiple PKC isotypes, PKC-alpha, PKC-beta, and PKC-delta, and inhibits ligand-initiated mobilization of intracellular Ca(2+) and uptake of extracellular Ca(2+).	Tetradecanoylphorbol Acetate	46-71	protein kinase C beta	Homo sapiens	122-130
10871059-6	2000	Interestingly, TCRalpha synthesis was differentially induced by phorbol myristate acetate treatment in CEM and CEM.NK(R) cells and TCRalpha proteins synthesized in CEM.NK(R) cells showed reduced survival compared to those made in CEM cells.	Tetradecanoylphorbol Acetate	64-89	T cell receptor alpha constant	Homo sapiens	15-23
10871059-6	2000	Interestingly, TCRalpha synthesis was differentially induced by phorbol myristate acetate treatment in CEM and CEM.NK(R) cells and TCRalpha proteins synthesized in CEM.NK(R) cells showed reduced survival compared to those made in CEM cells.	Tetradecanoylphorbol Acetate	64-89	T cell receptor alpha constant	Homo sapiens	131-139
11443050-3	2001	In neutrophilic HL60 cells, the PKC activator phorbol myristate acetate (PMA) activates multiple PKC isotypes, PKC-alpha, PKC-beta, and PKC-delta, and inhibits ligand-initiated mobilization of intracellular Ca(2+) and uptake of extracellular Ca(2+).	Tetradecanoylphorbol Acetate	46-71	protein kinase C delta	Homo sapiens	136-145
11443050-3	2001	In neutrophilic HL60 cells, the PKC activator phorbol myristate acetate (PMA) activates multiple PKC isotypes, PKC-alpha, PKC-beta, and PKC-delta, and inhibits ligand-initiated mobilization of intracellular Ca(2+) and uptake of extracellular Ca(2+).	Tetradecanoylphorbol Acetate	73-76	protein kinase C beta	Homo sapiens	122-130
11443050-3	2001	In neutrophilic HL60 cells, the PKC activator phorbol myristate acetate (PMA) activates multiple PKC isotypes, PKC-alpha, PKC-beta, and PKC-delta, and inhibits ligand-initiated mobilization of intracellular Ca(2+) and uptake of extracellular Ca(2+).	Tetradecanoylphorbol Acetate	73-76	protein kinase C delta	Homo sapiens	136-145
11424089-7	2001	Moreover, inhibiting the PKCdelta activation, either pharmacologically with phorbol 12-myristate 13-acetate or with bisindolymaleimide II or genetically by transient transfection of a dominant negative PKCdelta, significantly inhibited the transcriptional activation of HSF and HIF-1 by hypoxia.	Tetradecanoylphorbol Acetate	76-107	protein kinase C delta	Homo sapiens	25-33
10754199-5	2000	In mouse fibroblast cells, momordin I suppressed the AP-1 activity induced by phorbol 12-myristate 13-acetate (PMA), as well as blocked the de novo synthesis of AP-1 protein.	Tetradecanoylphorbol Acetate	78-109	jun proto-oncogene	Mus musculus	53-57
11438978-2	2001	The TPA-responsive element plays an important role in the trans-synaptically-induced transcription of the TH gene in the AM, whereas it does not appear to be involved in the SCG (Trocme et al.	Tetradecanoylphorbol Acetate	4-7	tyrosine hydroxylase	Rattus norvegicus	106-108
10754199-5	2000	In mouse fibroblast cells, momordin I suppressed the AP-1 activity induced by phorbol 12-myristate 13-acetate (PMA), as well as blocked the de novo synthesis of AP-1 protein.	Tetradecanoylphorbol Acetate	111-114	jun proto-oncogene	Mus musculus	53-57
10749687-7	2000	Furthermore, PMA-induced Pyk2 (and FAK) tyrosine phosphorylation was also observed when platelets adhered to immobilized fibrinogen.	Tetradecanoylphorbol Acetate	13-16	protein tyrosine kinase 2	Homo sapiens	35-38
11437382-2	2001	Here we reported that the expression of DAB2, a putative adaptor protein in cell signaling, was induced at the protein and mRNA levels upon 12-O-tetradecanoylphorbol-13-acetate-mediated megakaryocyte differentiation of human chronic myeloid leukemic K562 cells.	Tetradecanoylphorbol Acetate	140-176	DAB adaptor protein 2	Homo sapiens	40-44
10760470-5	2000	In addition, we found that the hLysoPLA I can be up-regulated by phorbol 12-myristate 13-acetate (PMA) stimulation, a process in which phospholipase A(2) is activated and lysophospholipids are generated in WISH cells.	Tetradecanoylphorbol Acetate	65-96	NCK interacting protein with SH3 domain	Homo sapiens	206-210
10760470-5	2000	In addition, we found that the hLysoPLA I can be up-regulated by phorbol 12-myristate 13-acetate (PMA) stimulation, a process in which phospholipase A(2) is activated and lysophospholipids are generated in WISH cells.	Tetradecanoylphorbol Acetate	98-101	NCK interacting protein with SH3 domain	Homo sapiens	206-210
11404234-4	2001	Treatment with phorbol ester [12-O-tetradecanoyl-phorbol-13-acetate (TPA) 100 nM], an activator of protein kinase C, significantly enhanced 1,25(OH)2D3-induced OPN mRNA and transcription but had no effect on VDR or on 24(OH)ase mRNA or transcription.	Tetradecanoylphorbol Acetate	30-67	secreted phosphoprotein 1	Rattus norvegicus	160-163
10753712-2	2000	Western blot analysis in PEL cell lines (TY-1 and BCBL-1) revealed that the expression of these proteins, except ORF73 (LANA), was induced by tetradecanoylphorbol acetate (TPA) treatment, indicating that these proteins are lytic proteins.	Tetradecanoylphorbol Acetate	142-170	LANA	Human gammaherpesvirus 8	113-118
10753712-2	2000	Western blot analysis in PEL cell lines (TY-1 and BCBL-1) revealed that the expression of these proteins, except ORF73 (LANA), was induced by tetradecanoylphorbol acetate (TPA) treatment, indicating that these proteins are lytic proteins.	Tetradecanoylphorbol Acetate	172-175	LANA	Human gammaherpesvirus 8	113-118
11404234-4	2001	Treatment with phorbol ester [12-O-tetradecanoyl-phorbol-13-acetate (TPA) 100 nM], an activator of protein kinase C, significantly enhanced 1,25(OH)2D3-induced OPN mRNA and transcription but had no effect on VDR or on 24(OH)ase mRNA or transcription.	Tetradecanoylphorbol Acetate	69-72	secreted phosphoprotein 1	Rattus norvegicus	160-163
11404234-5	2001	Studies using OPN promoter constructs indicate that TPA-enhanced OPN transcription is mediated by an effect on the OPN promoter separate from an effect on VDR.	Tetradecanoylphorbol Acetate	52-55	secreted phosphoprotein 1	Rattus norvegicus	14-17
11404234-5	2001	Studies using OPN promoter constructs indicate that TPA-enhanced OPN transcription is mediated by an effect on the OPN promoter separate from an effect on VDR.	Tetradecanoylphorbol Acetate	52-55	secreted phosphoprotein 1	Rattus norvegicus	65-68
11404234-5	2001	Studies using OPN promoter constructs indicate that TPA-enhanced OPN transcription is mediated by an effect on the OPN promoter separate from an effect on VDR.	Tetradecanoylphorbol Acetate	52-55	secreted phosphoprotein 1	Rattus norvegicus	65-68
11435619-9	2001	The observed receptor-induced stimulation of CaV1.3 channels could be mimicked by phorbol-12-myristate-13-acetate and was sensitive to inhibitors of protein kinases, but not to the phosphoinositol-3-kinase-inhibitor wortmannin, pointing to serine/threonine kinase-dependent regulation.	Tetradecanoylphorbol Acetate	82-113	calcium channel, voltage-dependent, L type, alpha 1D subunit L homeolog	Xenopus laevis	45-51
11396952-2	2001	Phorbor 12-tetradecanoate 13-acetate (TPA) with simultaneous addition of Bay K8644 mimicking ghrelin action caused a significant inhibition of the luciferase activity through the ghrelin receptor gene upstream proximal to -669 but not to -608 base pairs (bp).	Tetradecanoylphorbol Acetate	38-41	growth hormone secretagogue receptor	Homo sapiens	179-195
11396952-5	2001	These results suggest that both TPA/Bay K8644 and glucocorticoid downregulate human ghrelin receptor gene expression through the transcriptional mechanism involving some nuclear factors.	Tetradecanoylphorbol Acetate	32-35	growth hormone secretagogue receptor	Homo sapiens	84-100
10395944-2	1999	We previously reported that hPTP-J mRNA was detected significantly in Jurkat T lymphoma cells and its expression was completely down-regulated by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	146-171	protein tyrosine phosphatase receptor type U	Homo sapiens	28-34
11517513-4	2001	Interleukin (IL)-5 production by PBMCs stimulated with the combination of phorbol myristate acetate and ionomycin were reduced significantly 6 or 12 weeks after the treatment with supratast tosilate.	Tetradecanoylphorbol Acetate	74-99	interleukin 5	Homo sapiens	0-18
10409167-4	1999	Selective secretion of mucin glycoforms did not result from differences in receptor distribution, since cholinergic stimulation was found to increase intracellular free calcium in all cells and selective secretion was also observed when the cells were directly stimulated with the protein kinase C activator phorbol myristate acetate.	Tetradecanoylphorbol Acetate	308-333	LOC100508689	Homo sapiens	23-28
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	87-90	involucrin	Mus musculus	186-196
10447762-10	1999	Treatment with either A23187 or PMA caused electromobility changes of paxillin that were mainly a result of serine/threonine phosphorylation.	Tetradecanoylphorbol Acetate	32-35	paxillin	Rattus norvegicus	70-78
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	87-90	involucrin	Mus musculus	186-189
11401916-8	2001	The TPA-induced ODC activity in 3-mm skin biopsies was significantly lowered by 80 and 67% at the two dose levels.	Tetradecanoylphorbol Acetate	4-7	ornithine decarboxylase 1	Homo sapiens	16-19
10340932-13	1999	Rat alveolar macrophages were found to produce a low constitutive level of MMP-2 (72-kD gelatinase A) that was only modestly upregulated following stimulation with phorbol myristate acetate, bacterial lipopolysaccharide, or immunoglobulin A-containing immune complexes.	Tetradecanoylphorbol Acetate	164-189	matrix metallopeptidase 2	Rattus norvegicus	75-80
10339499-6	1999	In contrast, TPA + IFN-gamma costimulation neither increased the expression of Mad1 or other mad/mnt family genes nor altered heterodimerization or DNA-binding activity of Mad1.	Tetradecanoylphorbol Acetate	13-16	MAX dimerization protein 1	Homo sapiens	79-83
10339499-6	1999	In contrast, TPA + IFN-gamma costimulation neither increased the expression of Mad1 or other mad/mnt family genes nor altered heterodimerization or DNA-binding activity of Mad1.	Tetradecanoylphorbol Acetate	13-16	MAX dimerization protein 1	Homo sapiens	172-176
11401916-12	2001	TPA-induced ODC activity appears to be a relevant intermediate biological assay.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase 1	Homo sapiens	12-15
11398142-6	2001	Furthermore, when the cells were exposed to phorbol myristate acetate (PMA), it resulted in a reduction in ET(A) and ET(B) receptor binding sites by 41% and 34%, respectively, suggesting the involvement of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	44-69	endothelin receptor type B	Rattus norvegicus	117-122
10403539-0	1999	A diacetylenic spiroketal enol ether epoxide, AL-1, from Artemisia lactiflora inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion possibly by suppression of oxidative stress.	Tetradecanoylphorbol Acetate	87-123	ephrin A5	Mus musculus	46-50
10403539-3	1999	In a double TPA application system in mouse skin, double pretreatments of AL-1 (810 nmol) significantly suppressed double TPA application-induced H2O2 generation.	Tetradecanoylphorbol Acetate	12-15	ephrin A5	Mus musculus	74-78
10403539-3	1999	In a double TPA application system in mouse skin, double pretreatments of AL-1 (810 nmol) significantly suppressed double TPA application-induced H2O2 generation.	Tetradecanoylphorbol Acetate	122-125	ephrin A5	Mus musculus	74-78
10403539-4	1999	Pretreatment of AL-1 only before the second TPA treatment was sufficient to inhibit, while only with first treatment was not.	Tetradecanoylphorbol Acetate	44-47	ephrin A5	Mus musculus	16-20
10403539-5	1999	From these results we concluded that AL-1 is a specific inhibitor of the activation phase in H2O2 production induced by double TPA treatments.	Tetradecanoylphorbol Acetate	127-130	ephrin A5	Mus musculus	37-41
11398142-6	2001	Furthermore, when the cells were exposed to phorbol myristate acetate (PMA), it resulted in a reduction in ET(A) and ET(B) receptor binding sites by 41% and 34%, respectively, suggesting the involvement of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	71-74	endothelin receptor type B	Rattus norvegicus	117-122
10342885-6	1999	D3 induction by TPA was blocked by GF 109203X, an inhibitor of protein kinase C. In addition, the effects of TPA and bFGF were partially prevented by PD 98059, a specific inhibitor of MEK and the Erk signaling cascade.	Tetradecanoylphorbol Acetate	16-19	fibroblast growth factor 2	Rattus norvegicus	117-121
11423971-5	2001	Although Gem expression is rare in epithelial and hematopoietic cancer cell lines, constitutive Gem levels were detected in several neuroblastoma cell lines and could be further induced as much as 10-fold following treatment with PMA or the acetylcholine muscarinic agonist, carbachol.	Tetradecanoylphorbol Acetate	230-233	GTP binding protein (gene overexpressed in skeletal muscle)	Mus musculus	9-12
11423971-5	2001	Although Gem expression is rare in epithelial and hematopoietic cancer cell lines, constitutive Gem levels were detected in several neuroblastoma cell lines and could be further induced as much as 10-fold following treatment with PMA or the acetylcholine muscarinic agonist, carbachol.	Tetradecanoylphorbol Acetate	230-233	GTP binding protein (gene overexpressed in skeletal muscle)	Mus musculus	96-99
10424449-6	1999	GRX mRNA also increased in U937 cells differentiated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	56-87	glutaredoxin	Homo sapiens	0-3
11358830-0	2001	Organ-specific activation of activator protein-1 in transgenic mice by 12-o-tetradecanoylphorbol-13-acetate with different administration methods.	Tetradecanoylphorbol Acetate	71-107	jun proto-oncogene	Mus musculus	29-48
10424449-6	1999	GRX mRNA also increased in U937 cells differentiated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	89-92	glutaredoxin	Homo sapiens	0-3
11358830-5	2001	injection), we analyzed TPA-stimulated activator protein-1 (AP-1) activity in various organs (liver, kidney, brain, lung, spleen, heart, stomach, colon, esophagus, and skin) from transgenic mice expressing the AP-1 luciferase reporter gene.	Tetradecanoylphorbol Acetate	24-27	jun proto-oncogene	Mus musculus	39-58
10447727-3	1999	NK cells express CD69 after activation by different stimuli such as phorbol 12-myristate 13-acetate (PMA), interleukin (IL)-2, IL-12, interferon-alpha (IFN-alpha) or anti-CD16 monoclonal antibodies (mAbs).	Tetradecanoylphorbol Acetate	68-99	CD69 molecule	Homo sapiens	17-21
11358830-5	2001	injection), we analyzed TPA-stimulated activator protein-1 (AP-1) activity in various organs (liver, kidney, brain, lung, spleen, heart, stomach, colon, esophagus, and skin) from transgenic mice expressing the AP-1 luciferase reporter gene.	Tetradecanoylphorbol Acetate	24-27	jun proto-oncogene	Mus musculus	60-64
11358830-6	2001	Topical application of TPA by painting the skin on the back of mice raised AP-1 activity 122.6-fold, and the highest peak of AP-1 activity was at 12 h after administration of TPA.	Tetradecanoylphorbol Acetate	23-26	jun proto-oncogene	Mus musculus	75-79
10331498-7	1999	Furthermore, TALL-1 expression is dramatically down-regulated by phorbol myristate acetate/ionomycin.	Tetradecanoylphorbol Acetate	65-90	TNF superfamily member 13b	Homo sapiens	13-19
11358830-6	2001	Topical application of TPA by painting the skin on the back of mice raised AP-1 activity 122.6-fold, and the highest peak of AP-1 activity was at 12 h after administration of TPA.	Tetradecanoylphorbol Acetate	23-26	jun proto-oncogene	Mus musculus	125-129
10331502-6	1999	In addition, the inhibitory effect of PMA prevented anti-CD3-epsilon-stimulated DOR expression.	Tetradecanoylphorbol Acetate	38-41	CD3 antigen, epsilon polypeptide	Mus musculus	57-60
11358830-6	2001	Topical application of TPA by painting the skin on the back of mice raised AP-1 activity 122.6-fold, and the highest peak of AP-1 activity was at 12 h after administration of TPA.	Tetradecanoylphorbol Acetate	175-178	jun proto-oncogene	Mus musculus	125-129
11358830-7	2001	Drinking water containing TPA caused a 25.8-fold induction of AP-1 activity in the skin, whereas gavage feeding with TPA caused a 34.2-fold induction of AP-1 in the skin.	Tetradecanoylphorbol Acetate	26-29	jun proto-oncogene	Mus musculus	62-66
11358830-7	2001	Drinking water containing TPA caused a 25.8-fold induction of AP-1 activity in the skin, whereas gavage feeding with TPA caused a 34.2-fold induction of AP-1 in the skin.	Tetradecanoylphorbol Acetate	117-120	jun proto-oncogene	Mus musculus	153-157
10434531-4	1999	Our data show increased Cx 43 protein expression in Aroclor 1254 and TPA-treated cultures compared to controls, decreased Cx 43 protein level in those exposed to B[a]P, while Cx 43 gene expression (Cx 43 mRNA) was unaffected by the treatments.	Tetradecanoylphorbol Acetate	69-72	gap junction protein alpha 1	Homo sapiens	24-29
10411313-2	1999	TPA did not have any effect per se, but blunted the effect of PACAP-27 on both NPR-A density and NPR-A mRNA.	Tetradecanoylphorbol Acetate	0-3	adenylate cyclase activating polypeptide 1	Homo sapiens	62-67
11358830-9	2001	injection of TPA induced a 49.56-fold or 20.4-fold increase in AP-1 activity in the skin, respectively.	Tetradecanoylphorbol Acetate	13-16	jun proto-oncogene	Mus musculus	63-67
11358830-10	2001	The highest peaks of AP-1 activity in the skin were at 12 h after drinking, feeding, or injection of TPA.	Tetradecanoylphorbol Acetate	101-104	jun proto-oncogene	Mus musculus	21-25
10188728-4	1999	Short-term incubation with PMA induced a marked shift of isoforms alpha, betaI, betaII, gamma and eta to the particulate fraction.	Tetradecanoylphorbol Acetate	27-30	endothelin receptor type A	Rattus norvegicus	74-77
11358830-12	2001	injection of TPA raised AP-1 activity 13.9-fold, drinking TPA raised AP-1 activity 8.4-fold, and painting with TPA caused a 2.4-fold induction of AP-1 activity.	Tetradecanoylphorbol Acetate	13-16	jun proto-oncogene	Mus musculus	24-28
10188728-5	1999	Long-term incubation with PMA (0.1 microM, 6 hr) resulted in significant reduction of expression of conventional PKCs alpha, betaI, betaII and gamma and of the novel PKC eta to 10% to 26% of controls.	Tetradecanoylphorbol Acetate	26-29	endothelin receptor type A	Rattus norvegicus	126-129
11358830-12	2001	injection of TPA raised AP-1 activity 13.9-fold, drinking TPA raised AP-1 activity 8.4-fold, and painting with TPA caused a 2.4-fold induction of AP-1 activity.	Tetradecanoylphorbol Acetate	58-61	jun proto-oncogene	Mus musculus	69-73
10563991-6	1999	By in vitro kinase assay using myelin basic protein (MBP) as a PKC-specific substrate, we found that TPA treatment was able to increase PKC kinase activity by detection of phosphorylated MBP protein and TF-3 showed strongest inhibitory effect on its phosphorylation while EGCG was shown to be less effective.	Tetradecanoylphorbol Acetate	101-104	myelin basic protein	Mus musculus	31-51
11358830-12	2001	injection of TPA raised AP-1 activity 13.9-fold, drinking TPA raised AP-1 activity 8.4-fold, and painting with TPA caused a 2.4-fold induction of AP-1 activity.	Tetradecanoylphorbol Acetate	58-61	jun proto-oncogene	Mus musculus	69-73
10563991-6	1999	By in vitro kinase assay using myelin basic protein (MBP) as a PKC-specific substrate, we found that TPA treatment was able to increase PKC kinase activity by detection of phosphorylated MBP protein and TF-3 showed strongest inhibitory effect on its phosphorylation while EGCG was shown to be less effective.	Tetradecanoylphorbol Acetate	101-104	myelin basic protein	Mus musculus	53-56
10563991-6	1999	By in vitro kinase assay using myelin basic protein (MBP) as a PKC-specific substrate, we found that TPA treatment was able to increase PKC kinase activity by detection of phosphorylated MBP protein and TF-3 showed strongest inhibitory effect on its phosphorylation while EGCG was shown to be less effective.	Tetradecanoylphorbol Acetate	101-104	myelin basic protein	Mus musculus	187-190
11358830-12	2001	injection of TPA raised AP-1 activity 13.9-fold, drinking TPA raised AP-1 activity 8.4-fold, and painting with TPA caused a 2.4-fold induction of AP-1 activity.	Tetradecanoylphorbol Acetate	58-61	jun proto-oncogene	Mus musculus	69-73
10563991-7	1999	We also analyzed the AP-1 binding activity by electrophoretic mobility shift assay and c-Jun gene expression by northern blot and western blot, the results showed that TF-3 is the most potent inhibitor on TPA-induced AP-1 binding activity and c-Jun gene expression among these five tea polyphenols.	Tetradecanoylphorbol Acetate	205-208	jun proto-oncogene	Mus musculus	87-92
11358830-12	2001	injection of TPA raised AP-1 activity 13.9-fold, drinking TPA raised AP-1 activity 8.4-fold, and painting with TPA caused a 2.4-fold induction of AP-1 activity.	Tetradecanoylphorbol Acetate	58-61	jun proto-oncogene	Mus musculus	69-73
10563991-7	1999	We also analyzed the AP-1 binding activity by electrophoretic mobility shift assay and c-Jun gene expression by northern blot and western blot, the results showed that TF-3 is the most potent inhibitor on TPA-induced AP-1 binding activity and c-Jun gene expression among these five tea polyphenols.	Tetradecanoylphorbol Acetate	205-208	jun proto-oncogene	Mus musculus	217-221
11358830-14	2001	injection of TPA raised AP-1 activity 3.9-fold, drinking TPA induced a 1.2-fold increase in AP-1 activity, but painting with TPA had no effect.	Tetradecanoylphorbol Acetate	13-16	jun proto-oncogene	Mus musculus	24-28
10563991-7	1999	We also analyzed the AP-1 binding activity by electrophoretic mobility shift assay and c-Jun gene expression by northern blot and western blot, the results showed that TF-3 is the most potent inhibitor on TPA-induced AP-1 binding activity and c-Jun gene expression among these five tea polyphenols.	Tetradecanoylphorbol Acetate	205-208	jun proto-oncogene	Mus musculus	243-248
11358830-14	2001	injection of TPA raised AP-1 activity 3.9-fold, drinking TPA induced a 1.2-fold increase in AP-1 activity, but painting with TPA had no effect.	Tetradecanoylphorbol Acetate	57-60	jun proto-oncogene	Mus musculus	92-96
11358830-14	2001	injection of TPA raised AP-1 activity 3.9-fold, drinking TPA induced a 1.2-fold increase in AP-1 activity, but painting with TPA had no effect.	Tetradecanoylphorbol Acetate	57-60	jun proto-oncogene	Mus musculus	92-96
11358830-20	2001	These results indicate that the skin is the most sensitive organ to TPA induction of AP-1 activity.	Tetradecanoylphorbol Acetate	68-71	jun proto-oncogene	Mus musculus	85-89
11358830-21	2001	The data suggest that the organ-specific, tumor-promoting effect of TPA may be through AP-1 activation and phosphorylation of ERKs and p38 kinase.	Tetradecanoylphorbol Acetate	68-71	jun proto-oncogene	Mus musculus	87-91
10201899-4	1999	However, p38 MAPK is activated strongly and synergistically by either CD3/CD28 coligation or PMA/Ca2+ ionophore stimulation, which mimics TCR-CD3/CD28-mediated signaling.	Tetradecanoylphorbol Acetate	93-96	mitogen-activated protein kinase 14	Mus musculus	9-17
10201899-4	1999	However, p38 MAPK is activated strongly and synergistically by either CD3/CD28 coligation or PMA/Ca2+ ionophore stimulation, which mimics TCR-CD3/CD28-mediated signaling.	Tetradecanoylphorbol Acetate	93-96	CD3 antigen, epsilon polypeptide	Mus musculus	142-145
11465111-4	2001	The phorbol 12-myristate 13-acetate-augmented expression of CD28 on these cells can be blocked by actinomycin D, an RNA transcription inhibitor, and staurosporin, a protein kinase inhibitor.	Tetradecanoylphorbol Acetate	4-35	CD28 molecule	Homo sapiens	60-64
10222789-3	1999	We reviewed in this paper the functional analysis of gene promoter of Huntington disease gene so far reported and introduced our own data on the effect of db-cAMP and TPA on the promoter activity of Huntington disease (HD) gene and DRPLA gene.	Tetradecanoylphorbol Acetate	167-170	atrophin 1	Homo sapiens	232-237
10222789-4	1999	Db-cAMP and TPA activated DRPLA gene promoter but didn"t activate HD gene promoter.	Tetradecanoylphorbol Acetate	12-15	atrophin 1	Homo sapiens	26-31
11312276-3	2001	Using an immortalized hippocampal cell line that is particularly sensitive to oxidative stress, I show that activation of PKC by the phorbol ester tetradecanoylphorbol acetate (TPA) inhibits cell death via the stimulation of a complex protein phosphorylation pathway.	Tetradecanoylphorbol Acetate	177-180	protein kinase C delta	Homo sapiens	122-125
11312276-4	2001	TPA treatment leads to the rapid activation of extracellular signal-regulated kinase (ERK) and c-Jun NH2-terminal kinase (JNK), the inactivation of p38 mitogen-activated protein kinase (MAPK), and the downregulation of PKCdelta.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	219-227
10085090-6	1999	Phorbol 12-myristate 13-acetate activation of differentiated HL-60 granulocytic cells generated an oxidative burst that was sufficient to efficiently oxidize exogenous S100A8 within 10 min, and results implicate involvement of the myeloperoxidase system.	Tetradecanoylphorbol Acetate	0-31	S100 calcium binding protein A8	Homo sapiens	168-174
11285196-1	2001	Ongoing studies in our laboratory have demonstrated that dietary energy restriction (DER) inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 transcription factor binding to DNA in the epidermis of SENCAR mice.	Tetradecanoylphorbol Acetate	100-136	jun proto-oncogene	Mus musculus	151-155
10079079-1	1999	We previously observed that IFN gamma-inducible expression of the human MHC class II, HLA-DR alpha, gene was enhanced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) only in human monocytic leukemia THP-1 cells, but not in HeLa cells.	Tetradecanoylphorbol Acetate	136-172	major histocompatibility complex, class II, DR alpha	Homo sapiens	86-98
10079079-1	1999	We previously observed that IFN gamma-inducible expression of the human MHC class II, HLA-DR alpha, gene was enhanced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) only in human monocytic leukemia THP-1 cells, but not in HeLa cells.	Tetradecanoylphorbol Acetate	174-177	major histocompatibility complex, class II, DR alpha	Homo sapiens	86-98
11285196-1	2001	Ongoing studies in our laboratory have demonstrated that dietary energy restriction (DER) inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 transcription factor binding to DNA in the epidermis of SENCAR mice.	Tetradecanoylphorbol Acetate	138-141	jun proto-oncogene	Mus musculus	151-155
10193662-2	1999	TPA also increased the levels of mRNA for cyclooxygenase-2 and inducible nitric oxide synthase, suggesting that the increase in the production of prostaglandin E2 and nitric oxide is due to the increase in the levels of mRNA for cyclooxygenase-2 and inducible nitric oxide synthase, respectively.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	42-94
11285196-7	2001	The TPA-induced ERK activity in AL mice was accompanied by increased phosphorylation of ERK1 and ERK2 (P&lt; 0.05), which was abrogated in DER mice.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase 3	Mus musculus	88-92
10193662-2	1999	TPA also increased the levels of mRNA for cyclooxygenase-2 and inducible nitric oxide synthase, suggesting that the increase in the production of prostaglandin E2 and nitric oxide is due to the increase in the levels of mRNA for cyclooxygenase-2 and inducible nitric oxide synthase, respectively.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	229-281
11285196-12	2001	Taken together, our results indicated for the first time that DER blocked the TPA stimulation of ERK activity and suggested that the inhibition of TPA-induced AP-1 activity by DER is likely through inhibition of ERK but not JNK or p38 kinase pathway.	Tetradecanoylphorbol Acetate	78-81	jun proto-oncogene	Mus musculus	159-163
10217536-11	1999	In accordance with these effects of MAFP, PKC activator phorbol 12-myristate 13-acetate (PMA) increased PGE2 release and caused activation of PKCbeta, ERKs and p38 MAPK.	Tetradecanoylphorbol Acetate	56-87	mitogen-activated protein kinase 14	Mus musculus	160-168
10217536-11	1999	In accordance with these effects of MAFP, PKC activator phorbol 12-myristate 13-acetate (PMA) increased PGE2 release and caused activation of PKCbeta, ERKs and p38 MAPK.	Tetradecanoylphorbol Acetate	89-92	mitogen-activated protein kinase 14	Mus musculus	160-168
11285196-12	2001	Taken together, our results indicated for the first time that DER blocked the TPA stimulation of ERK activity and suggested that the inhibition of TPA-induced AP-1 activity by DER is likely through inhibition of ERK but not JNK or p38 kinase pathway.	Tetradecanoylphorbol Acetate	147-150	jun proto-oncogene	Mus musculus	159-163
11285196-12	2001	Taken together, our results indicated for the first time that DER blocked the TPA stimulation of ERK activity and suggested that the inhibition of TPA-induced AP-1 activity by DER is likely through inhibition of ERK but not JNK or p38 kinase pathway.	Tetradecanoylphorbol Acetate	147-150	mitogen-activated protein kinase 14	Mus musculus	231-234
11254678-4	2001	PMA also induces accumulation of cyclin D3-cdk4 complexes in B-2 cells; however, these complexes do not phosphorylate pRb.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase 4	Homo sapiens	43-47
10224665-4	1999	Rac-GTP enhances phosphorylation of LIMK1 and cofilin, which leads to accumulation of F-actin, while Rac-GDP and PMA reduce these effects.	Tetradecanoylphorbol Acetate	113-116	LIM domain kinase 1	Homo sapiens	36-41
11254678-5	2001	Thus, PMA is sufficient to induce synthesis and assembly of cyclin D3-cdk4 complexes in B-1 and B-2 cells; however, PMA triggers cyclin D3-cdk4 activation only in B-1 cells.	Tetradecanoylphorbol Acetate	6-9	cyclin dependent kinase 4	Homo sapiens	70-74
11254678-5	2001	Thus, PMA is sufficient to induce synthesis and assembly of cyclin D3-cdk4 complexes in B-1 and B-2 cells; however, PMA triggers cyclin D3-cdk4 activation only in B-1 cells.	Tetradecanoylphorbol Acetate	116-119	cyclin dependent kinase 4	Homo sapiens	139-143
11313860-5	2001	Furthermore, thymocytes and splenic T cells from lck-Mad1 transgenic mice display a profound proliferative defect in response to activation with either PMA/Ionomycin or immobilized anti-CD3/CD28 antibody.	Tetradecanoylphorbol Acetate	152-155	lymphocyte protein tyrosine kinase	Mus musculus	49-52
10024677-2	1999	TGF-alpha secretion into culture supernatants became measurable when TPA 0.5 microM was added.	Tetradecanoylphorbol Acetate	69-72	transforming growth factor alpha	Homo sapiens	0-9
10102471-13	1999	In conclusion, we propose that the pathway PKCbeta-MEK-MAPK p42 is a potential linear route for PAI-1 synthesis leading to morphological changes and adherence linked to PMA-induced differentiation in HL-60 cells.	Tetradecanoylphorbol Acetate	169-172	protein kinase C beta	Homo sapiens	43-50
11298136-9	2001	The results obtained during a three year period in the proliferation assays show an impaired PMA (phorbol myristate acetate) activation in specific T lymphocyte activation pathways (CD69, CD26, CD28, CD3, PHA, PWM and Con A mediated) but not in others (CD2, ionomycin, and Ig surface receptor).	Tetradecanoylphorbol Acetate	98-123	CD69 molecule	Homo sapiens	182-186
11601238-5	1999	PMA, a PKC activator, also induced the expression of TF activity in BAEC.	Tetradecanoylphorbol Acetate	0-3	LOC101909187	Bos taurus	53-55
9933619-6	1999	When exposed to TPA, the grafted skin of wild type and TGF-beta1 knockout mice underwent a hyperplastic response similar to that of normal mouse skin.	Tetradecanoylphorbol Acetate	16-19	transforming growth factor, beta 1	Mus musculus	55-64
11298136-9	2001	The results obtained during a three year period in the proliferation assays show an impaired PMA (phorbol myristate acetate) activation in specific T lymphocyte activation pathways (CD69, CD26, CD28, CD3, PHA, PWM and Con A mediated) but not in others (CD2, ionomycin, and Ig surface receptor).	Tetradecanoylphorbol Acetate	98-123	CD28 molecule	Homo sapiens	194-198
9933619-8	1999	Analysis of cultured keratinocytes treated with purified TGF-beta isoforms revealed that TGF-beta3 plays a direct and specific function in protecting keratinocytes against TPA-induced cell death.	Tetradecanoylphorbol Acetate	172-175	transforming growth factor, beta 1	Mus musculus	57-65
11181529-5	2001	We now demonstrate that PMA-induced hydroxamate (IC3)-inhibitable GHR proteolysis and GHBP shedding were also detected in murine 3T3-F442A and 3T3-L1 preadipocytes and in Chinese hamster ovary (CHO) cells stably expressing rabbit GHR (rbGHR), although the degree of GHBP shedding was much smaller for murine GHR than for rabbit or human GHRs.	Tetradecanoylphorbol Acetate	24-27	olfactory receptor family 4 subfamily C member 58	Mus musculus	49-52
10426567-0	1999	Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway.	Tetradecanoylphorbol Acetate	260-291	pancreatic and duodenal homeobox 1	Homo sapiens	168-207
10426567-0	1999	Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway.	Tetradecanoylphorbol Acetate	260-291	pancreatic and duodenal homeobox 1	Homo sapiens	209-214
10426567-0	1999	Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway.	Tetradecanoylphorbol Acetate	293-296	pancreatic and duodenal homeobox 1	Homo sapiens	168-207
10426567-0	1999	Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway.	Tetradecanoylphorbol Acetate	293-296	pancreatic and duodenal homeobox 1	Homo sapiens	209-214
11181529-5	2001	We now demonstrate that PMA-induced hydroxamate (IC3)-inhibitable GHR proteolysis and GHBP shedding were also detected in murine 3T3-F442A and 3T3-L1 preadipocytes and in Chinese hamster ovary (CHO) cells stably expressing rabbit GHR (rbGHR), although the degree of GHBP shedding was much smaller for murine GHR than for rabbit or human GHRs.	Tetradecanoylphorbol Acetate	24-27	growth hormone receptor	Oryctolagus cuniculus	230-233
11287749-1	2001	Treatment of cultured human hepatoma HepG2 cells with the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), results in an increase in tyrosine phosphorylation of several proteins, including the focal adhesion kinase (FAK) and paxillin using anti-phosphotyrosine Western blotting and immunoprecipitation.	Tetradecanoylphorbol Acetate	92-128	protein tyrosine kinase 2	Homo sapiens	222-243
11287749-1	2001	Treatment of cultured human hepatoma HepG2 cells with the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), results in an increase in tyrosine phosphorylation of several proteins, including the focal adhesion kinase (FAK) and paxillin using anti-phosphotyrosine Western blotting and immunoprecipitation.	Tetradecanoylphorbol Acetate	92-128	protein tyrosine kinase 2	Homo sapiens	245-248
9915850-4	1999	In the presence of phorbol 12-myristate 13-acetate, both CHO-CD80 and CHO-CD86, like anti-CD28 mAb, were capable of stimulating cytokine production from both human peripheral T cells and Jurkat T cells.	Tetradecanoylphorbol Acetate	19-50	CD28 molecule	Homo sapiens	90-94
11287749-1	2001	Treatment of cultured human hepatoma HepG2 cells with the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), results in an increase in tyrosine phosphorylation of several proteins, including the focal adhesion kinase (FAK) and paxillin using anti-phosphotyrosine Western blotting and immunoprecipitation.	Tetradecanoylphorbol Acetate	130-133	protein tyrosine kinase 2	Homo sapiens	222-243
11287749-1	2001	Treatment of cultured human hepatoma HepG2 cells with the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), results in an increase in tyrosine phosphorylation of several proteins, including the focal adhesion kinase (FAK) and paxillin using anti-phosphotyrosine Western blotting and immunoprecipitation.	Tetradecanoylphorbol Acetate	130-133	protein tyrosine kinase 2	Homo sapiens	245-248
10753712-3	2000	Immunofluorescence assay in primary PEL cells derived from pericardial effusion and PEL cell lines with and without TPA treatment revealed that primary PEL cells exhibited the same expression pattern as noninduced PEL cell lines, and the treatment changed localization of K8, ORF59, and ORF65 proteins.	Tetradecanoylphorbol Acetate	116-119	ORF59	Human gammaherpesvirus 8	276-281
11238722-1	2001	Tyrosine hydroxylase (TH) gene promoter activity is increased in PC12 cells that are treated with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	155-158	tyrosine hydroxylase	Rattus norvegicus	22-24
9927065-7	1999	Immunofluorescence for beta-galactosidase demonstrated that TPA caused a significant increase in the percentage of beta-galactosidase-positive areas in 12:1 and 4:1 mixtures.	Tetradecanoylphorbol Acetate	60-63	galactosidase beta 1	Homo sapiens	115-133
11238722-2	2001	Mutagenesis of either the cAMP responsive element (CRE) or the activator protein-1 element (AP1) within the TH gene proximal promoter leads to a dramatic inhibition of the TPA response.	Tetradecanoylphorbol Acetate	172-175	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-82
11238722-2	2001	Mutagenesis of either the cAMP responsive element (CRE) or the activator protein-1 element (AP1) within the TH gene proximal promoter leads to a dramatic inhibition of the TPA response.	Tetradecanoylphorbol Acetate	172-175	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-95
10718345-6	2000	Resveratrol treatment caused a significant impairment of cyclooxygenase-2 (COX-2) induction stimulated by LPS and PMA or by O2- or H2O2 exposure.	Tetradecanoylphorbol Acetate	114-117	prostaglandin-endoperoxide synthase 2	Mus musculus	57-73
9886845-2	1999	A luciferase reporter gene was constructed downstream from either a promoter for the mouse vas deferens protein, or a trimerized 12-O-tetradecanoyl phorbol-13-acetate-response element site whose transcriptions are activated by androgen and 12-O-tetradecanoyl phorbol-13-acetate, a potent AP-1 activator.	Tetradecanoylphorbol Acetate	129-166	jun proto-oncogene	Mus musculus	288-292
10718345-6	2000	Resveratrol treatment caused a significant impairment of cyclooxygenase-2 (COX-2) induction stimulated by LPS and PMA or by O2- or H2O2 exposure.	Tetradecanoylphorbol Acetate	114-117	prostaglandin-endoperoxide synthase 2	Mus musculus	75-80
11238722-2	2001	Mutagenesis of either the cAMP responsive element (CRE) or the activator protein-1 element (AP1) within the TH gene proximal promoter leads to a dramatic inhibition of the TPA response.	Tetradecanoylphorbol Acetate	172-175	tyrosine hydroxylase	Rattus norvegicus	108-110
9886855-4	1999	Phorbol myristate acetate (10(-6) M) also increased a 6-kb mRNA at 6 h. By immunofluorescence microscopy, Flup increased perinuclear staining for FGF-2 protein at 6 h and nuclear labeling at 24 h. Immunogold labeling of calvariae revealed that treatment with Flup for 3 h caused a transition of FGF expression from matrix to cells and an increase in cytoplasmic labeling for FGF-2 protein in periosteal cells and in osteoblasts.	Tetradecanoylphorbol Acetate	0-25	fibroblast growth factor 2	Rattus norvegicus	146-151
11238722-3	2001	The TH CRE and TH AP1 sites are also independently responsive to TPA in minimal promoter constructs.	Tetradecanoylphorbol Acetate	65-68	tyrosine hydroxylase	Rattus norvegicus	4-6
9886855-4	1999	Phorbol myristate acetate (10(-6) M) also increased a 6-kb mRNA at 6 h. By immunofluorescence microscopy, Flup increased perinuclear staining for FGF-2 protein at 6 h and nuclear labeling at 24 h. Immunogold labeling of calvariae revealed that treatment with Flup for 3 h caused a transition of FGF expression from matrix to cells and an increase in cytoplasmic labeling for FGF-2 protein in periosteal cells and in osteoblasts.	Tetradecanoylphorbol Acetate	0-25	fibroblast growth factor 2	Rattus norvegicus	375-380
10713064-6	2000	Overexpression of PKCdelta markedly enhanced the apoptotic effect of phorbol 12-myristate 13-acetate in LNCaP cells.	Tetradecanoylphorbol Acetate	69-100	protein kinase C delta	Homo sapiens	18-26
11238722-3	2001	The TH CRE and TH AP1 sites are also independently responsive to TPA in minimal promoter constructs.	Tetradecanoylphorbol Acetate	65-68	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	18-21
9886389-5	1999	Similar to PMA treatment, which abolished both CXCR4 receptor expression and the chemotactic response of Jurkat cells to SDF-1, anti-CD3 Ab treatment reduced cell surface expression of CXCR4 to 65% of the control value, an effect that was blocked by protein kinase C inhibitors.	Tetradecanoylphorbol Acetate	11-14	C-X-C motif chemokine ligand 12	Homo sapiens	121-126
11238722-5	2001	In CREB-deficient cells, the response of the full TH gene proximal promoter or the independent response of the TH CRE by itself to TPA is inhibited.	Tetradecanoylphorbol Acetate	131-134	tyrosine hydroxylase	Rattus norvegicus	111-113
11238722-6	2001	The TPA-inducibility of TH mRNA is also blocked in CREB-deficient cells.	Tetradecanoylphorbol Acetate	4-7	tyrosine hydroxylase	Rattus norvegicus	24-26
10499870-4	1999	Although BNP showed itself no stimulatory potential on superoxide anion release in PMN, it enhanced significantly the stimulatory potential of cell stimuli such as fMLP or phorbol 12-myristate 13-acetate (PMA) in PMN.	Tetradecanoylphorbol Acetate	172-203	natriuretic peptide B	Homo sapiens	9-12
10499870-4	1999	Although BNP showed itself no stimulatory potential on superoxide anion release in PMN, it enhanced significantly the stimulatory potential of cell stimuli such as fMLP or phorbol 12-myristate 13-acetate (PMA) in PMN.	Tetradecanoylphorbol Acetate	205-208	natriuretic peptide B	Homo sapiens	9-12
10693967-4	2000	Stimulation of Na+,K(+)-ATPase activity by Ang II was dependent on protein kinase C (PKC) activation because PKC antagonists abolished the inducing effect of Ang II and the PKC activator phorbol 12-myristate 13-acetate enhanced transporter activity.	Tetradecanoylphorbol Acetate	187-218	protein kinase C, delta	Rattus norvegicus	85-88
10693967-4	2000	Stimulation of Na+,K(+)-ATPase activity by Ang II was dependent on protein kinase C (PKC) activation because PKC antagonists abolished the inducing effect of Ang II and the PKC activator phorbol 12-myristate 13-acetate enhanced transporter activity.	Tetradecanoylphorbol Acetate	187-218	protein kinase C, delta	Rattus norvegicus	109-112
11238722-7	2001	Expression of the PKA inhibitor protein, PKI, also inhibits the independent response of the TH CRE to TPA.	Tetradecanoylphorbol Acetate	102-105	tyrosine hydroxylase	Rattus norvegicus	92-94
9858570-7	1999	The functional role of MEKK-1 in TPA-induced SAPK activity was further supported by the demonstration that the expression of a dominant negative MEKK-1 mutant abrogated this response.	Tetradecanoylphorbol Acetate	33-36	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	23-29
11238722-8	2001	Our results support the hypothesis that TPA stimulates the TH gene promoter via signaling pathways that activate either the TH AP1 or TH CRE sites.	Tetradecanoylphorbol Acetate	40-43	tyrosine hydroxylase	Rattus norvegicus	59-61
9858570-7	1999	The functional role of MEKK-1 in TPA-induced SAPK activity was further supported by the demonstration that the expression of a dominant negative MEKK-1 mutant abrogated this response.	Tetradecanoylphorbol Acetate	33-36	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	145-151
9858570-8	1999	These findings indicate that PKCbeta activation is necessary for activation of the MEKK-1--&gt;SEK1--&gt;SAPK cascade in the TPA response of myeloid leukemia cells.	Tetradecanoylphorbol Acetate	125-128	protein kinase C beta	Homo sapiens	29-36
11238722-8	2001	Our results support the hypothesis that TPA stimulates the TH gene promoter via signaling pathways that activate either the TH AP1 or TH CRE sites.	Tetradecanoylphorbol Acetate	40-43	tyrosine hydroxylase	Rattus norvegicus	124-126
9858570-8	1999	These findings indicate that PKCbeta activation is necessary for activation of the MEKK-1--&gt;SEK1--&gt;SAPK cascade in the TPA response of myeloid leukemia cells.	Tetradecanoylphorbol Acetate	125-128	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	83-89
10693967-4	2000	Stimulation of Na+,K(+)-ATPase activity by Ang II was dependent on protein kinase C (PKC) activation because PKC antagonists abolished the inducing effect of Ang II and the PKC activator phorbol 12-myristate 13-acetate enhanced transporter activity.	Tetradecanoylphorbol Acetate	187-218	protein kinase C, delta	Rattus norvegicus	109-112
11238722-8	2001	Our results support the hypothesis that TPA stimulates the TH gene promoter via signaling pathways that activate either the TH AP1 or TH CRE sites.	Tetradecanoylphorbol Acetate	40-43	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	127-130
11238722-8	2001	Our results support the hypothesis that TPA stimulates the TH gene promoter via signaling pathways that activate either the TH AP1 or TH CRE sites.	Tetradecanoylphorbol Acetate	40-43	tyrosine hydroxylase	Rattus norvegicus	124-126
10681599-8	2000	The influence of phorbol 12-myristate 13-acetate on both EPCR release and inhibition of protein C activation are enhanced by microtubule disruption with nocodazole.	Tetradecanoylphorbol Acetate	17-48	protein C receptor	Homo sapiens	57-61
9857183-0	1998	A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.	Tetradecanoylphorbol Acetate	85-88	protein kinase C delta	Homo sapiens	60-68
11170182-5	2001	Pretreatment with Gly-Arg-Gly-Asp-Ser peptide inhibited the SSC increasing action of 12-o-tetradecanoyl-phorbol-13-acetate (TPA, 0.5 microM) plus fibronectin, but not that of TPA plus laminin.	Tetradecanoylphorbol Acetate	124-127	fibronectin 1 S homeolog	Xenopus laevis	146-157
9857183-2	1998	One such protein is the heparin-binding EGF-like growth factor (HB-EGF) that exists in a membrane-anchored form which is converted to a soluble form upon cell stimulation with TPA, an activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	176-179	protein kinase C delta	Homo sapiens	215-218
9857183-4	1998	Furthermore, the presence of constitutively active PKCdelta or MDC9 results in the shedding of the ectodomain of proHB-EGF, whereas MDC9 mutants lacking the metalloprotease domain, as well as kinase-negative PKCdelta, suppress the TPA-induced shedding of the ectodomain.	Tetradecanoylphorbol Acetate	231-234	protein kinase C delta	Homo sapiens	51-59
10381133-2	1998	Application of TPA to mouse skin induces oxidative stress, as evidenced by numerous biochemical responses, including significant generation of H2O2 and enhanced levels of myeloperoxidase and oxidized glutathione reductase activities and decreases in glutathione levels and superoxide dismutase activity.	Tetradecanoylphorbol Acetate	15-18	glutathione reductase	Mus musculus	200-221
10381133-3	1998	TPA treatment also elevates the expression of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), c-myc, c-fos, c-jun, transforming growth factor-beta1 (TGF-beta1) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	72-88
10381133-3	1998	TPA treatment also elevates the expression of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), c-myc, c-fos, c-jun, transforming growth factor-beta1 (TGF-beta1) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	0-3	cytochrome c oxidase II, mitochondrial	Mus musculus	90-95
10679258-3	2000	We show that the activities of both ERK-1 and ERK-2 are upregulated in this model in response to TPA.	Tetradecanoylphorbol Acetate	97-100	mitogen-activated protein kinase 3	Mus musculus	36-41
11170182-7	2001	High concentration of TPA (5 microM) markedly increased the SSC frequency by itself and occluded the SSC increasing action of fibronectin.	Tetradecanoylphorbol Acetate	22-25	fibronectin 1 S homeolog	Xenopus laevis	126-137
10381133-3	1998	TPA treatment also elevates the expression of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), c-myc, c-fos, c-jun, transforming growth factor-beta1 (TGF-beta1) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	0-3	jun proto-oncogene	Mus musculus	112-117
10381133-3	1998	TPA treatment also elevates the expression of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), c-myc, c-fos, c-jun, transforming growth factor-beta1 (TGF-beta1) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	0-3	transforming growth factor, beta 1	Mus musculus	119-151
11170182-8	2001	Very low concentration of TPA (0.05 microM) markedly enhanced the SSC frequency when the cells were plated onto fibronectin- or laminin-coated substratum for 1 day.	Tetradecanoylphorbol Acetate	26-29	fibronectin 1 S homeolog	Xenopus laevis	112-124
10381133-3	1998	TPA treatment also elevates the expression of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), c-myc, c-fos, c-jun, transforming growth factor-beta1 (TGF-beta1) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	0-3	transforming growth factor, beta 1	Mus musculus	153-162
10676642-14	2000	However, carcinomas developed rapidly in the T7-PKCepsilon mice treated with 7, 12-dimethylbenz[a]anthracene and TPA.	Tetradecanoylphorbol Acetate	113-116	protein kinase C, epsilon	Mus musculus	48-58
10381133-6	1998	As judged by reverse transcriptase-polymerase chain reaction (RT-PCR), TPA-induced increases in the expression of c-fos and TGF-beta1 were selectively inhibited.	Tetradecanoylphorbol Acetate	71-74	transforming growth factor, beta 1	Mus musculus	124-133
9884090-5	1998	Treatment of cells with staurosporine and Ro 31-8220 inhibited the PMA-induced potentiation of both AA release and cyclic AMP accumulation, while Go 6976 (an inhibitor of classical PKC isoforms) and LY 379196 (a specific inhibitor of PKCbeta) inhibited the AA response but failed to affect the enhancement of the cyclic AMP response by PMA.	Tetradecanoylphorbol Acetate	67-70	protein kinase C, beta	Mus musculus	234-241
9885901-5	1998	By contrast, phorbol myristate acetate (PMA) and/or ionomycin-induced apoptosis had much slower kinetics, were preceded by an early increase of NF-kappaB/RelA-p50, AP-1 and NUR-77 activities, and were insensitive to proteasome inhibition.	Tetradecanoylphorbol Acetate	13-38	RELA proto-oncogene, NF-kB subunit	Homo sapiens	154-158
10646501-6	2000	MMP-2 expression was constitutive and remained unchanged at both the mRNA and protein levels in response to RA, tumor necrosis factor-alpha (TNFalpha), or phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	188-191	matrix metallopeptidase 2	Homo sapiens	0-5
10644756-7	2000	The inhibitory effect of PDGF on GH-induced tyrosyl phosphorylation of JAK2 and GHR is abolished by depletion of 4beta-phorbol 12-myristate 13-acetate (PMA)-sensitive PKCs with chronic PMA treatment and is severely inhibited by GF109203X, an inhibitor of PKCs.	Tetradecanoylphorbol Acetate	113-150	Janus kinase 2	Homo sapiens	71-75
9885901-5	1998	By contrast, phorbol myristate acetate (PMA) and/or ionomycin-induced apoptosis had much slower kinetics, were preceded by an early increase of NF-kappaB/RelA-p50, AP-1 and NUR-77 activities, and were insensitive to proteasome inhibition.	Tetradecanoylphorbol Acetate	40-43	RELA proto-oncogene, NF-kB subunit	Homo sapiens	154-158
11062238-6	2001	Furthermore, RhoB inhibited decrease in the cellular amount of IkappaBalpha after genotoxic stress as well as after tumor necrosis factor alpha and 12-O-tetradecanoylphorbol acetate treatment.	Tetradecanoylphorbol Acetate	148-181	ras homolog family member B	Homo sapiens	13-17
9840290-5	1998	Tumor necrosis factor alpha (TFNalpha)-, interleukin 6 (IL-6)-, and phorbol myristate acid (PMA)-induced HIV-1 expression, as determined by reverse transcriptase (RT) assay, was significantly inhibited in cells transduced with pLXSN-D8SFv-Rev, compared with cells transduced with pLXSN.	Tetradecanoylphorbol Acetate	92-95	Rev	Human immunodeficiency virus 1	239-242
10644756-7	2000	The inhibitory effect of PDGF on GH-induced tyrosyl phosphorylation of JAK2 and GHR is abolished by depletion of 4beta-phorbol 12-myristate 13-acetate (PMA)-sensitive PKCs with chronic PMA treatment and is severely inhibited by GF109203X, an inhibitor of PKCs.	Tetradecanoylphorbol Acetate	152-155	Janus kinase 2	Homo sapiens	71-75
10644756-7	2000	The inhibitory effect of PDGF on GH-induced tyrosyl phosphorylation of JAK2 and GHR is abolished by depletion of 4beta-phorbol 12-myristate 13-acetate (PMA)-sensitive PKCs with chronic PMA treatment and is severely inhibited by GF109203X, an inhibitor of PKCs.	Tetradecanoylphorbol Acetate	185-188	Janus kinase 2	Homo sapiens	71-75
11221859-7	2001	However, within 15-20 weeks of 12-O-tetradecanoylphorbol-13-acetate promotion, 40% of T7-PKCepsilon mice developed at least one carcinoma compared with 7% of the wild-type mice.	Tetradecanoylphorbol Acetate	31-67	protein kinase C, epsilon	Mus musculus	89-99
11436980-0	2001	Effects of calmodulin antagonist (W-7) on phorbol ester (PMA)-induced contractile response in isolated rat aorta.	Tetradecanoylphorbol Acetate	57-60	calmodulin 1	Rattus norvegicus	11-21
12749772-8	2000	An L-selectin cytoplasmic tail deletion mutant (344del.15) expressed in L1.2 pre-B cells was down-modulated by PMA or sulfatides, but not Dreg 200.	Tetradecanoylphorbol Acetate	111-114	LINE1 retrotransposable element 1	Homo sapiens	72-76
10022774-6	1998	The suppression by TPA preincubation of the rhFSH-induced cAMP synthesis was completely abolished by the protein kinase C (PKC) inhibitor staurosporine (STR).	Tetradecanoylphorbol Acetate	19-22	protein kinase C beta	Homo sapiens	123-126
12539551-4	2001	The expression of IL-4 and IL-5 mRNA and protein of asthmatic T lymphocytes stimulated with PMA was significantly higher than that of asthmatic T lymphocytes stimulated without PMA respectively (P &lt; 0.01) and that of normal T lymphocytes stimulated with PMA respectively (P &lt; 0.01).	Tetradecanoylphorbol Acetate	92-95	interleukin 5	Homo sapiens	27-31
12539551-4	2001	The expression of IL-4 and IL-5 mRNA and protein of asthmatic T lymphocytes stimulated with PMA was significantly higher than that of asthmatic T lymphocytes stimulated without PMA respectively (P &lt; 0.01) and that of normal T lymphocytes stimulated with PMA respectively (P &lt; 0.01).	Tetradecanoylphorbol Acetate	177-180	interleukin 5	Homo sapiens	27-31
12539551-4	2001	The expression of IL-4 and IL-5 mRNA and protein of asthmatic T lymphocytes stimulated with PMA was significantly higher than that of asthmatic T lymphocytes stimulated without PMA respectively (P &lt; 0.01) and that of normal T lymphocytes stimulated with PMA respectively (P &lt; 0.01).	Tetradecanoylphorbol Acetate	177-180	interleukin 5	Homo sapiens	27-31
9813014-5	1998	Interestingly, human immunodeficiency virus type 1 Tat, which affects endothelial functions, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate and culture on fibrin gels, which promote endothelial differentiation in vitro, all down-regulate EDF-1 expression both at the RNA and protein levels.	Tetradecanoylphorbol Acetate	115-151	endothelial differentiation related factor 1	Homo sapiens	250-255
10632964-4	2000	Ovine US caused dose-dependent inhibition of lymphocyte proliferation induced by phorbol myristol acetate (PMA), an activator of protein kinase C. The PHA-induced increase in CD25 expression was inhibited in peripheral blood mononuclear leukocytes (PBML) by OvUS.	Tetradecanoylphorbol Acetate	107-110	interleukin 2 receptor subunit alpha	Homo sapiens	175-179
12539551-5	2001	The expression of IL-4 and IL-5 mRNA and protein of asthmatic T lymphocytes stimulated with PMA and Ro31-8220 was significantly lower than that of asthmatic T lymphocytes stimulated only with PMA respectively (P &lt; 0.01).	Tetradecanoylphorbol Acetate	92-95	interleukin 5	Homo sapiens	27-31
11169207-5	2001	However, the incubation of cells expressing human or rabbit pIgR with pIgA induces a comparable IP3 production, and pIgR-transcytosis of either species is accelerated by the protein kinase C (PKC)-activator phorbol myristate acetate.	Tetradecanoylphorbol Acetate	207-232	polymeric immunoglobulin receptor	Oryctolagus cuniculus	60-64
10601254-6	1999	Immunofluorescence data demonstrate that PMA addition to hematopoietic cells induces the translocation of Smad3 to the nucleus.	Tetradecanoylphorbol Acetate	41-44	SMAD family member 3	Homo sapiens	106-111
10572244-10	1999	PD98059, an inhibitor of the upstream kinase that activates p42/p44 MAP kinase, suppressed the induction of HSP27 stimulated by PGF(2alpha) or TPA.	Tetradecanoylphorbol Acetate	143-146	cyclin-dependent kinase 20	Mus musculus	60-63
10572244-10	1999	PD98059, an inhibitor of the upstream kinase that activates p42/p44 MAP kinase, suppressed the induction of HSP27 stimulated by PGF(2alpha) or TPA.	Tetradecanoylphorbol Acetate	143-146	mitogen-activated protein kinase 3	Mus musculus	64-78
9804763-3	1998	In a previous paper, we reported that p40(phox) undergoes phosphorylation on multiple sites upon stimulation of the NADPH oxidase by either phorbol 12-myristate 13-acetate or by formyl peptide with a time course that is strongly correlated with that of superoxide production (Fuchs, A., Bouin, A. P., Rabilloud, T., and Vignais, P. V. (1997) Eur.	Tetradecanoylphorbol Acetate	140-171	interleukin 9	Homo sapiens	38-41
9804846-8	1998	Tyrosine phosphorylation of PKCdelta in response to phorbol 12-myristate 13-acetate and platelet-derived growth factor occurred only in chimeras which contained the PKCdelta regulatory domain.	Tetradecanoylphorbol Acetate	52-83	protein kinase C delta	Homo sapiens	28-36
9804846-8	1998	Tyrosine phosphorylation of PKCdelta in response to phorbol 12-myristate 13-acetate and platelet-derived growth factor occurred only in chimeras which contained the PKCdelta regulatory domain.	Tetradecanoylphorbol Acetate	52-83	protein kinase C delta	Homo sapiens	165-173
9794433-6	1998	4) In PMA-stimulated B cells from an X91+ CGD patient in which p22phox was normally expressed and gp91phox was present but lacked five amino acids, translocation of p47phox to the membranes was unaffected, but p67phox and p40phox were poorly translocated, and the production of O2- was greatly reduced with respect to that by normal B cells.	Tetradecanoylphorbol Acetate	6-9	neutrophil cytosolic factor 2	Homo sapiens	210-217
10614787-5	1999	In HMC-1 cells, bacterial internalization was stimulated by protein kinase C (PKC) activation [short-term phorbol myristate acetate (PMA) treatment] and dramatically decreased by PKC inhibitors or PKC depletion (long-term PMA treatment).	Tetradecanoylphorbol Acetate	106-131	protein kinase C delta	Homo sapiens	78-81
10614787-5	1999	In HMC-1 cells, bacterial internalization was stimulated by protein kinase C (PKC) activation [short-term phorbol myristate acetate (PMA) treatment] and dramatically decreased by PKC inhibitors or PKC depletion (long-term PMA treatment).	Tetradecanoylphorbol Acetate	133-136	protein kinase C delta	Homo sapiens	78-81
11169207-5	2001	However, the incubation of cells expressing human or rabbit pIgR with pIgA induces a comparable IP3 production, and pIgR-transcytosis of either species is accelerated by the protein kinase C (PKC)-activator phorbol myristate acetate.	Tetradecanoylphorbol Acetate	207-232	polymeric immunoglobulin receptor	Oryctolagus cuniculus	116-120
11102578-6	2000	On the other hand, chronic application of phorbol-12-myristate-13-acetate (1 microM) inhibited the effect of bFGF on neuronal survival, without inhibiting the other bFGF actions.	Tetradecanoylphorbol Acetate	42-73	fibroblast growth factor 2	Rattus norvegicus	109-113
10567579-5	1999	Activation of PKCdelta by 12-O-tetradecanoylphorbol-13-acetate (TPA) at a nanomolar concentration was lethal to normal and neoplastic mouse and human keratinocytes overexpressing PKCdelta.	Tetradecanoylphorbol Acetate	26-62	protein kinase C delta	Homo sapiens	179-187
10567579-5	1999	Activation of PKCdelta by 12-O-tetradecanoylphorbol-13-acetate (TPA) at a nanomolar concentration was lethal to normal and neoplastic mouse and human keratinocytes overexpressing PKCdelta.	Tetradecanoylphorbol Acetate	64-67	protein kinase C delta	Homo sapiens	179-187
9773783-3	1998	In the present study, the effect of UUF on basal and calcitriol-induced membrane bound CD14 expression of monocytes activated by phorbol 12-myristate 13-acetate was evaluated.	Tetradecanoylphorbol Acetate	129-160	CD14 molecule	Homo sapiens	87-91
9794231-1	1998	We have uniformly examined the regulatory steps required by oncogenic Ras, Src, EGF and phorbol 12-myristate 13-acetate (PMA) to activate Raf-1.	Tetradecanoylphorbol Acetate	88-119	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	138-143
9794231-1	1998	We have uniformly examined the regulatory steps required by oncogenic Ras, Src, EGF and phorbol 12-myristate 13-acetate (PMA) to activate Raf-1.	Tetradecanoylphorbol Acetate	121-124	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	138-143
9733728-8	1998	Co-transfection of the hINV promoter with dominant negative forms of Ras, MEKK1, MEK1, MEK7, MEK3, p38/RK, and c-Jun inhibit the TPA-dependent increase.	Tetradecanoylphorbol Acetate	129-132	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	74-79
10567579-8	1999	Subcellular fractionation indicated that PKCdelta translocated to a mitochondrial enriched fraction after TPA activation, and this finding was confirmed by confocal microscopy of cells expressing a transfected PKCdelta-green fluorescent protein fusion protein.	Tetradecanoylphorbol Acetate	106-109	protein kinase C delta	Homo sapiens	41-49
11078718-3	2000	Both TNF-alpha and the PKC-activator phorbol 12-myristate 13-acetate triggered phosphorylation of p60TNFR.	Tetradecanoylphorbol Acetate	37-68	protein kinase C delta	Homo sapiens	23-26
10569809-9	1999	Western immunoblot analysis showed that the observed effect of silymarin on COX activity was due to inhibition of TPA-inducible COX-2 with no change in constitutive COX-1 protein levels.	Tetradecanoylphorbol Acetate	114-117	cytochrome c oxidase II, mitochondrial	Mus musculus	128-133
10597286-2	1999	HGF/SF or a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced disruption of cell-cell adhesion, which was accompanied by endocytosis of both E-cadherin and c-Met.	Tetradecanoylphorbol Acetate	27-63	cadherin 1	Canis lupus familiaris	158-168
10597286-2	1999	HGF/SF or a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced disruption of cell-cell adhesion, which was accompanied by endocytosis of both E-cadherin and c-Met.	Tetradecanoylphorbol Acetate	27-63	MET proto-oncogene, receptor tyrosine kinase	Canis lupus familiaris	173-178
10597286-2	1999	HGF/SF or a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced disruption of cell-cell adhesion, which was accompanied by endocytosis of both E-cadherin and c-Met.	Tetradecanoylphorbol Acetate	65-68	cadherin 1	Canis lupus familiaris	158-168
9716492-8	1998	In HT-1080 cells, MT1-MMP was further processed to an inactive, 43 kDa cell surface form when overexpressed, or when the cells were treated with PMA.	Tetradecanoylphorbol Acetate	145-148	matrix metallopeptidase 14	Homo sapiens	18-25
11096038-7	2000	Regarding the increased expression on in vitro stimulation with phorbol myristate acetate, blunted upregulation was obtained during dialysis using Excebrane membranes for CD11c and CD45 expression on granulocytes and CD14 expression on monocytes.	Tetradecanoylphorbol Acetate	64-89	integrin subunit alpha X	Homo sapiens	171-176
10367403-1	1998	The tetradecanoyl phorbol acetate (TPA)-inducible sequence 11 (TIS11) family of early-response proteins consists of at least five members.	Tetradecanoylphorbol Acetate	4-33	ZFP36 ring finger protein	Homo sapiens	63-68
10367403-1	1998	The tetradecanoyl phorbol acetate (TPA)-inducible sequence 11 (TIS11) family of early-response proteins consists of at least five members.	Tetradecanoylphorbol Acetate	35-38	ZFP36 ring finger protein	Homo sapiens	63-68
10597286-2	1999	HGF/SF or a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced disruption of cell-cell adhesion, which was accompanied by endocytosis of both E-cadherin and c-Met.	Tetradecanoylphorbol Acetate	65-68	MET proto-oncogene, receptor tyrosine kinase	Canis lupus familiaris	173-178
10597286-7	1999	In these cell lines, the HGF- or TPA-induced coendocytosis of E-cadherin and c-Met was inhibited, but the coendocytosis of E-cadherin and c-Met in response to reduction of medium Ca2+ was not affected.	Tetradecanoylphorbol Acetate	33-36	cadherin 1	Canis lupus familiaris	62-72
10597286-7	1999	In these cell lines, the HGF- or TPA-induced coendocytosis of E-cadherin and c-Met was inhibited, but the coendocytosis of E-cadherin and c-Met in response to reduction of medium Ca2+ was not affected.	Tetradecanoylphorbol Acetate	33-36	MET proto-oncogene, receptor tyrosine kinase	Canis lupus familiaris	77-82
10597286-7	1999	In these cell lines, the HGF- or TPA-induced coendocytosis of E-cadherin and c-Met was inhibited, but the coendocytosis of E-cadherin and c-Met in response to reduction of medium Ca2+ was not affected.	Tetradecanoylphorbol Acetate	33-36	cadherin 1	Canis lupus familiaris	123-133
10597286-7	1999	In these cell lines, the HGF- or TPA-induced coendocytosis of E-cadherin and c-Met was inhibited, but the coendocytosis of E-cadherin and c-Met in response to reduction of medium Ca2+ was not affected.	Tetradecanoylphorbol Acetate	33-36	MET proto-oncogene, receptor tyrosine kinase	Canis lupus familiaris	138-143
10597286-9	1999	These results suggest that disruption of cell-cell adhesion is involved in the HGF- or TPA-induced coendocytosis of E-cadherin and c-Met in MDCK cells, and that the Rho and Rab family members indirectly regulate this coendocytosis.	Tetradecanoylphorbol Acetate	87-90	cadherin 1	Canis lupus familiaris	116-126
10597286-9	1999	These results suggest that disruption of cell-cell adhesion is involved in the HGF- or TPA-induced coendocytosis of E-cadherin and c-Met in MDCK cells, and that the Rho and Rab family members indirectly regulate this coendocytosis.	Tetradecanoylphorbol Acetate	87-90	MET proto-oncogene, receptor tyrosine kinase	Canis lupus familiaris	131-136
9720718-4	1998	These double CD7 and myeloid antigen (CD13 and/or CD33) positive progenitors tend to lose their CD7 expression, while retaining their myeloid characteristics, after in vitro culture with the differentiation-inducing agent phorbol ester (TPA).	Tetradecanoylphorbol Acetate	237-240	alanyl aminopeptidase, membrane	Homo sapiens	38-42
9685416-6	1998	Hence, the pervanadate and 12-O-tetradecanoylphorbol-13-acetate-induced proteolytic cleavage of ErbB-4 seem to proceed by different mechanisms, although both require metalloprotease activity.	Tetradecanoylphorbol Acetate	27-63	erb-b2 receptor tyrosine kinase 4	Homo sapiens	96-102
11096038-7	2000	Regarding the increased expression on in vitro stimulation with phorbol myristate acetate, blunted upregulation was obtained during dialysis using Excebrane membranes for CD11c and CD45 expression on granulocytes and CD14 expression on monocytes.	Tetradecanoylphorbol Acetate	64-89	CD14 molecule	Homo sapiens	217-221
11106549-7	2000	We also induced skin tumors in the mice with the MMP-9 reporter transgene with 7, 12-dimethylbenz[a]anthracene (DMBA) treatment followed by phorbol 12 myristate 13-acetate (TPA).	Tetradecanoylphorbol Acetate	140-171	matrix metallopeptidase 9	Mus musculus	49-54
9825917-5	1998	Phorbol 12-myristate 13-acetate, which binds to the site on PKCdelta to which the endogenous activator sn-1,2-diacylglycerol binds, also increased the tyrosine phosphorylation of PKCdelta.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, delta	Rattus norvegicus	60-68
10558995-6	1999	In p44 MAPK-/- thymocytes, proliferation in response to activation with a monoclonal antibody to the T cell receptor in the presence of phorbol myristate acetate was severely reduced even though activation of p42 MAPK was more sustained in these cells.	Tetradecanoylphorbol Acetate	136-161	mitogen-activated protein kinase 3	Mus musculus	3-6
9825917-5	1998	Phorbol 12-myristate 13-acetate, which binds to the site on PKCdelta to which the endogenous activator sn-1,2-diacylglycerol binds, also increased the tyrosine phosphorylation of PKCdelta.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, delta	Rattus norvegicus	179-187
11108241-10	2000	Corresponding to the induced shedding of GHBP from Null/R + T cells, PMA treatment caused a significant loss of immunoblottable GHR in Null/R+T, but not in Null/R cells.	Tetradecanoylphorbol Acetate	69-72	growth hormone receptor	Oryctolagus cuniculus	128-131
9683525-7	1998	Examination of the levels of cyclins A and B1 demonstrated that the levels of these cyclins were not limiting for entrance into M. However, the addition of TPA blocked the increase in p34(cdc2)/cyclin B1 kinase activity.	Tetradecanoylphorbol Acetate	156-159	alpha and gamma adaptin binding protein	Homo sapiens	184-187
9683525-8	1998	In cells treated with TPA, most p34(cdc2) was found in the slowly migrating forms on Western blots, which contained increased levels of phosphotyrosine.	Tetradecanoylphorbol Acetate	22-25	alpha and gamma adaptin binding protein	Homo sapiens	32-35
10545405-0	1999	Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis.	Tetradecanoylphorbol Acetate	130-133	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	36-41
11125308-3	2000	Concanavalin A or phorbol myristate acetate/calcium ionophore/anti-CD3 stimulation of spleen cells from H2(b) congenic mice induced less IL-1, IL-2, IFN-gamma and MIF mRNA and/or protein than the equivalent cells from H2(d) mice.	Tetradecanoylphorbol Acetate	18-43	interleukin 1 complex	Mus musculus	137-141
10674883-6	1999	Here, we demonstrate the effects of steroids/thyroids/retinoids and of activators of protein kinase A (forskolin, Forsk) and C (12-O-tetradecanoylphorbol-13-acetate, TPA), on growth and expression of c-erbB and RARs in MCF-7 breast cancer cells, which contain high levels of RAR-alpha and -gamma, and which express significant amounts of c-erbB-2 and -3.	Tetradecanoylphorbol Acetate	128-164	arginyl-tRNA synthetase 1	Homo sapiens	211-215
11125308-3	2000	Concanavalin A or phorbol myristate acetate/calcium ionophore/anti-CD3 stimulation of spleen cells from H2(b) congenic mice induced less IL-1, IL-2, IFN-gamma and MIF mRNA and/or protein than the equivalent cells from H2(d) mice.	Tetradecanoylphorbol Acetate	18-43	histocompatibility 2, D region	Mus musculus	218-223
9648920-4	1998	Down-regulation of PKC-isoforms by 12-O-tetradecanoylphorbol-13-acetate or pretreatment with the PKC inhibitor calphostin C, completely blocked PDGF action on GJC and Cx43.	Tetradecanoylphorbol Acetate	35-71	gap junction protein alpha 1	Homo sapiens	167-171
11152283-13	2000	Deletion mutagenesis demonstrated the importance of the 12-O-tetradecanoylphorbol-13-acetate response elements within the c-jun promoter for basal and NGF-mediated transcriptional induction.	Tetradecanoylphorbol Acetate	56-92	nerve growth factor	Rattus norvegicus	151-154
9685743-4	1998	Treatments with concanavalin A (Con A) and a phorbor ester (TPA) enhanced the MT1-MMP expression, but only Con A stimulated the proGelA activation in many cell lines.	Tetradecanoylphorbol Acetate	60-63	matrix metallopeptidase 14	Homo sapiens	78-85
10532946-3	1999	BTEB2 mRNA expression is rapidly and persistently induced in SMCs by phorbol 12-myristate 13-acetate (PMA) and basic fibroblast growth factor.	Tetradecanoylphorbol Acetate	69-100	Kruppel like factor 5	Homo sapiens	0-5
11087878-8	2000	Incubation of granule cells with both dibutyryl-cAMP (dbcAMP) and phorbol 12-myristate 13-acetate (PMA) mimicked the inhibitory effect of PACAP on caspase-3.	Tetradecanoylphorbol Acetate	66-97	adenylate cyclase activating polypeptide 1	Rattus norvegicus	138-143
10508860-7	1999	By monitoring fluorescent recombinant protein and by gel mobility shift assays, PS1 was shown to accelerate the translocation of QM from the cytoplasm to the nucleus and to thereby suppress the binding of c-Jun homodimer to 12-O-tetradecanoylphorbol-13- acetate (TPA)-responsive element (TRE).	Tetradecanoylphorbol Acetate	224-261	presenilin 1	Homo sapiens	80-83
10508860-7	1999	By monitoring fluorescent recombinant protein and by gel mobility shift assays, PS1 was shown to accelerate the translocation of QM from the cytoplasm to the nucleus and to thereby suppress the binding of c-Jun homodimer to 12-O-tetradecanoylphorbol-13- acetate (TPA)-responsive element (TRE).	Tetradecanoylphorbol Acetate	263-266	presenilin 1	Homo sapiens	80-83
9651321-1	1998	The 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive element-2 site (-272 to -278) on cystatin A gene is critical for TPA-dependent regulation.	Tetradecanoylphorbol Acetate	4-40	cystatin A	Homo sapiens	91-101
9651321-1	1998	The 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive element-2 site (-272 to -278) on cystatin A gene is critical for TPA-dependent regulation.	Tetradecanoylphorbol Acetate	42-45	cystatin A	Homo sapiens	91-101
9651321-1	1998	The 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive element-2 site (-272 to -278) on cystatin A gene is critical for TPA-dependent regulation.	Tetradecanoylphorbol Acetate	123-126	cystatin A	Homo sapiens	91-101
10514413-4	1999	In this study, we show that NAB2 is rapidly and transiently expressed in vascular smooth muscle cells (VSMC) in response to the model agonist phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	142-173	NGFI-A binding protein 2	Homo sapiens	28-32
11087878-8	2000	Incubation of granule cells with both dibutyryl-cAMP (dbcAMP) and phorbol 12-myristate 13-acetate (PMA) mimicked the inhibitory effect of PACAP on caspase-3.	Tetradecanoylphorbol Acetate	66-97	caspase 3	Rattus norvegicus	147-156
10514413-4	1999	In this study, we show that NAB2 is rapidly and transiently expressed in vascular smooth muscle cells (VSMC) in response to the model agonist phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	175-178	NGFI-A binding protein 2	Homo sapiens	28-32
9665805-4	1998	Upon induction by TPA of an inflammatory epidermal hyperplasia (regenerative hyperplasia) the number of PGHS-2-expressing keratinocytes scattered throughout the basal but not the suprabasal compartment of the interfollicular epidermis was found to be increased while PGHS-1 expression remained unchanged.	Tetradecanoylphorbol Acetate	18-21	prostaglandin-endoperoxide synthase 2	Mus musculus	104-110
9665805-5	1998	PGHS-2 immunoreactivity in paraffin sections from TPA-treated skin showed a nuclear in some and a perinuclear and cytoplasmic localization in other keratinocytes.	Tetradecanoylphorbol Acetate	50-53	prostaglandin-endoperoxide synthase 2	Mus musculus	0-6
11087878-8	2000	Incubation of granule cells with both dibutyryl-cAMP (dbcAMP) and phorbol 12-myristate 13-acetate (PMA) mimicked the inhibitory effect of PACAP on caspase-3.	Tetradecanoylphorbol Acetate	99-102	adenylate cyclase activating polypeptide 1	Rattus norvegicus	138-143
10091935-5	1998	TPA-treated B16F1 cells showed enhanced release of basic FGF (bFGF) and vascular endothelial growth factor (VEGF) and increased angiogenic capacity and lung colony formation in vivo.	Tetradecanoylphorbol Acetate	0-3	fibroblast growth factor 2	Mus musculus	51-60
10493914-2	1999	The alpha(2A)AR-mediated inhibition of forskolin-stimulated cAMP accumulation was completely ablated by CTX pretreatment only after additional treatment with PMA.	Tetradecanoylphorbol Acetate	158-161	adrenoceptor alpha 2A	Rattus norvegicus	4-15
10091935-5	1998	TPA-treated B16F1 cells showed enhanced release of basic FGF (bFGF) and vascular endothelial growth factor (VEGF) and increased angiogenic capacity and lung colony formation in vivo.	Tetradecanoylphorbol Acetate	0-3	fibroblast growth factor 2	Mus musculus	62-66
11087878-8	2000	Incubation of granule cells with both dibutyryl-cAMP (dbcAMP) and phorbol 12-myristate 13-acetate (PMA) mimicked the inhibitory effect of PACAP on caspase-3.	Tetradecanoylphorbol Acetate	99-102	caspase 3	Rattus norvegicus	147-156
10091935-7	1998	However, both cell lines showed an induction of VEGF as well as bFGF expression by TPA treatment suggesting that in BL6 cells antagonistic factors, inhibiting the angiogenic and metastatic capacity, are induced by this treatment.	Tetradecanoylphorbol Acetate	83-86	fibroblast growth factor 2	Mus musculus	64-68
11089555-10	2000	The phorbol ester TPA, an activator of protein kinase C (PKC), blocked apoptosis due to serum deprivation.	Tetradecanoylphorbol Acetate	18-21	protein kinase C delta	Homo sapiens	57-60
9733598-12	1998	CONCLUSION: IM inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice.	Tetradecanoylphorbol Acetate	64-67	fibroblast growth factor 2	Mus musculus	24-28
11089555-14	2000	Of these PKC isoforms, only PKCdelta has been shown to be activated by TPA.	Tetradecanoylphorbol Acetate	71-74	protein kinase C delta	Homo sapiens	9-12
11089555-14	2000	Of these PKC isoforms, only PKCdelta has been shown to be activated by TPA.	Tetradecanoylphorbol Acetate	71-74	protein kinase C delta	Homo sapiens	28-36
11069028-8	2000	Moreover, the differentiation status of these Raf-responsive cells was more immature upon Raf activation as culture with the differentiation-inducing agent phorbol 12 myristate 13-acetate (PMA) and beta-estradiol resulted in decreased levels of the CD11b and CD18 integrin molecules on the cell surface.	Tetradecanoylphorbol Acetate	156-187	zinc fingers and homeoboxes 2	Homo sapiens	46-49
9632690-8	1998	These hydrophobic residues appeared to be required for the binding of 14-3-3zeta to distinct activation states of Raf-1 because mutations V176D, L216D, L220D, and L227D reduced the interaction of 14-3-3zeta with Raf-1 from both phorbol 12-myristate 13-acetate-stimulated and unstimulated Jurkat T cells.	Tetradecanoylphorbol Acetate	228-259	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	114-119
11069028-8	2000	Moreover, the differentiation status of these Raf-responsive cells was more immature upon Raf activation as culture with the differentiation-inducing agent phorbol 12 myristate 13-acetate (PMA) and beta-estradiol resulted in decreased levels of the CD11b and CD18 integrin molecules on the cell surface.	Tetradecanoylphorbol Acetate	156-187	zinc fingers and homeoboxes 2	Homo sapiens	90-93
9636365-3	1998	The LTR-mediated synergy induced by cholera toxin (Ctx), a potent activator of the cAMP-dependent PKA pathway, and the PKC activator phorbol 12-myristate 13-acetate (PMA) was abrogated by a PKC-beta-specific inhibitor (LY333531).	Tetradecanoylphorbol Acetate	133-164	protein kinase C beta	Homo sapiens	190-198
11069028-8	2000	Moreover, the differentiation status of these Raf-responsive cells was more immature upon Raf activation as culture with the differentiation-inducing agent phorbol 12 myristate 13-acetate (PMA) and beta-estradiol resulted in decreased levels of the CD11b and CD18 integrin molecules on the cell surface.	Tetradecanoylphorbol Acetate	189-192	zinc fingers and homeoboxes 2	Homo sapiens	46-49
9601059-2	1998	Previously we showed that stimulation of phosphatidylcholine (PtdCho) synthesis by PMA in SK-N-MC human neuroblastoma cells required overexpression of MARCKS, whereas PKCalpha alone was insufficient.	Tetradecanoylphorbol Acetate	83-86	myristoylated alanine rich protein kinase C substrate	Homo sapiens	151-157
11069028-8	2000	Moreover, the differentiation status of these Raf-responsive cells was more immature upon Raf activation as culture with the differentiation-inducing agent phorbol 12 myristate 13-acetate (PMA) and beta-estradiol resulted in decreased levels of the CD11b and CD18 integrin molecules on the cell surface.	Tetradecanoylphorbol Acetate	189-192	zinc fingers and homeoboxes 2	Homo sapiens	90-93
10918063-3	2000	PKC inhibitor ablated PMA-stimulated expression of endogenous SPRR1B and reporter gene expression driven by SPRR1B promoter.	Tetradecanoylphorbol Acetate	22-25	protein kinase C delta	Homo sapiens	0-3
9579785-4	1998	The effect of PACAP on cell survival was mimicked by dibutyryladenosine 3",5"-cyclic-monophosphate but not phorbol 12-myristate 13-acetate suggesting that only the adenylyl cyclase pathway is involved in the neurotrophic activity of PACAP.	Tetradecanoylphorbol Acetate	107-138	adenylate cyclase activating polypeptide 1	Rattus norvegicus	14-19
9600091-2	1998	When plasmids containing a different length of the bovine GAL-promoter fused to luciferase were transfected into the human neuroblastoma cell line (SK-N-SH subclone SH-SY5Y), a PMA-responsive element was identified in the promoter-region -68 to -46 base pairs (bp).	Tetradecanoylphorbol Acetate	177-180	galanin and GMAP prepropeptide	Bos taurus	58-61
10918063-14	2000	Together, these results suggest that a PKCdelta/Ras/MEKK1/MKK1-dependent/AP-1 pathway regulates the PMA-inducible expression of the SPRR1B in tracheobronchial epithelial cells.	Tetradecanoylphorbol Acetate	100-103	protein kinase C delta	Homo sapiens	39-47
10918063-14	2000	Together, these results suggest that a PKCdelta/Ras/MEKK1/MKK1-dependent/AP-1 pathway regulates the PMA-inducible expression of the SPRR1B in tracheobronchial epithelial cells.	Tetradecanoylphorbol Acetate	100-103	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	52-57
9564040-5	1998	In control cells, Ang II and TPA produced minimal increases in Ras-GTP level and Raf kinase activity.	Tetradecanoylphorbol Acetate	29-32	zinc fingers and homeoboxes 2	Homo sapiens	81-84
11004668-7	2000	In contrast, the total amount and distribution of PKC beta2 remained almost unchanged with 10(-8) M PMA up to 21 hr.	Tetradecanoylphorbol Acetate	100-103	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	54-59
9603453-6	1998	Restimulation with the protein kinase C activator phorbol 12-myristate 13-acetate and the calcium ionophore ionomycin or an agonistic anti-CD3 monoclonal antibody induced significant up-regulation of surface TRAIL and CD95L in CD3+, TCRalphabeta cells with CD4+ or CD8+ phenotype.	Tetradecanoylphorbol Acetate	50-81	Fas ligand (TNF superfamily, member 6)	Mus musculus	218-223
11012779-7	2000	Enhancement of cytokine production was also observed in GM-CSF-treated macrophages after stimulation by phorbol 12-myristate 13-acetate (PMA), thus indicating that GM-CSF affects both CD14-dependent and -independent cytokine production.	Tetradecanoylphorbol Acetate	104-135	CD14 molecule	Homo sapiens	184-188
9553058-2	1998	We have identified a distal IL-2 enhancer regulated by the Raf-MEK-ERK signaling pathway, which can be induced by TPA/ionomycin treatment.	Tetradecanoylphorbol Acetate	114-117	zinc fingers and homeoboxes 2	Homo sapiens	59-62
9553058-7	1998	Furthermore, the JNK/SAPK signaling pathway cooperates with the Raf-MEK-ERK cascade in TPA/ionomycin-induced DSE activity.	Tetradecanoylphorbol Acetate	87-90	zinc fingers and homeoboxes 2	Homo sapiens	64-67
9599013-5	1998	Furthermore, 1,25-D3 also abolishes the induction of tenascin-C by serum or the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate.	Tetradecanoylphorbol Acetate	95-132	tenascin C	Mus musculus	53-63
11012779-7	2000	Enhancement of cytokine production was also observed in GM-CSF-treated macrophages after stimulation by phorbol 12-myristate 13-acetate (PMA), thus indicating that GM-CSF affects both CD14-dependent and -independent cytokine production.	Tetradecanoylphorbol Acetate	137-140	CD14 molecule	Homo sapiens	184-188
9745617-9	1998	TPA also strongly induced cyclin D1 expression in P+ (but not in P-) JB6 cells, but this induction started prior to the expression of cyclin A and cyclin B1.	Tetradecanoylphorbol Acetate	0-3	cyclin D1	Homo sapiens	26-35
9528965-6	1998	Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate was sufficient to activate both MAPK and raf-1 kinase.	Tetradecanoylphorbol Acetate	40-71	RAF1	Bos taurus	113-118
11061546-15	2000	In agreement with the semiquantitative RT-PCR results, Western blot analysis detected a decrease in ERalpha and ERbeta proteins levels in hGLCs after treatment with hCG (10 IU/mL), GnRH (0.1 micromol/L), 8-bromo-cAMP (1 mmol/L), forskolin (10 micromol/L), or phorbol 12-myristate 13 acetate (10 micromol/L).	Tetradecanoylphorbol Acetate	259-290	estrogen receptor 2	Homo sapiens	112-118
9628324-9	1998	Dexamethasone and phorbol ester (TPA) specifically reduced the AFP mRNA level without affecting that of DBP.	Tetradecanoylphorbol Acetate	33-36	alpha-fetoprotein	Rattus norvegicus	63-66
11036825-3	2000	METHODS: CD69 expression on lymphocytes was assessed by flow cytometry after incubation with different cytokines, chemokines, phorbol myristate acetate, or calcium ionophore in the presence or absence of CSA, MTX, or both.	Tetradecanoylphorbol Acetate	126-151	CD69 molecule	Homo sapiens	9-13
9535217-9	1998	PMA and okadaic acid induced an increase in HSF1 phosphorylation in both vector- and HSP-70 cDNA-transfected cells, although levels of phosphorylated HSF1 in HSP-70 cDNA-transfected cells were lower than those in vector-transfected cells.	Tetradecanoylphorbol Acetate	0-3	heat shock transcription factor 1	Homo sapiens	44-48
11018520-2	2000	However, their activators (extracellular signal related kinase (ERK)1/ERK2) were stimulated normally in mitogen- and stress-activated protein kinase (MSK)1-/- and wild type cells in response to tetradecanoylphorbol acetate (TPA) and epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	194-222	mitogen-activated protein kinase 3	Mus musculus	27-69
9525279-4	1998	ICAM-1 protein was localized to epidermal keratinocytes and vascular endothelium in TPA-treated skin and to proliferating papilloma cells.	Tetradecanoylphorbol Acetate	84-87	intercellular adhesion molecule 1	Mus musculus	0-6
11018520-2	2000	However, their activators (extracellular signal related kinase (ERK)1/ERK2) were stimulated normally in mitogen- and stress-activated protein kinase (MSK)1-/- and wild type cells in response to tetradecanoylphorbol acetate (TPA) and epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	194-222	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	150-155
9525279-7	1998	In addition, injection of either anti-ICAM-1 adhesion molecule antibody alone (P &lt; 0.004) or in combination with anti-beta2 integrin antibody (P &lt; 0.001) significantly inhibited TPA-induced production of 7,8-dihydroxy-2"-deoxyguanosine (8-OHdG) immunoreactive proteins by epidermal keratinocytes.	Tetradecanoylphorbol Acetate	184-187	intercellular adhesion molecule 1	Mus musculus	38-44
9525279-8	1998	Beta2 integrin/ICAM-1 adhesion molecules work in concert to regulate migration, retention and functional activation of leukocytes within the dermis during TPA-induced skin inflammation and within stromal tissue of papillomas that form during multi-stage carcinogenesis.	Tetradecanoylphorbol Acetate	155-158	intercellular adhesion molecule 1	Mus musculus	15-21
11018520-2	2000	However, their activators (extracellular signal related kinase (ERK)1/ERK2) were stimulated normally in mitogen- and stress-activated protein kinase (MSK)1-/- and wild type cells in response to tetradecanoylphorbol acetate (TPA) and epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	224-227	mitogen-activated protein kinase 3	Mus musculus	27-69
11018520-3	2000	TPA and EGF induced the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser-133 and ATF1 at Ser-63 in wild type cells and this was abolished by inhibition of the mitogen-activated protein kinase cascade.	Tetradecanoylphorbol Acetate	0-3	activating transcription factor 1	Mus musculus	111-115
10374432-7	1998	Cocultured with CD 80 transfected human breast carcinoma cell line MDA-453, anti-CD3 induced T cells proliferation and cytokine production were significantly increased in the presence of A23187 and PMA, but not with parental MDA-453.	Tetradecanoylphorbol Acetate	198-201	CD80 molecule	Homo sapiens	16-21
11018520-4	2000	In contrast, the TPA- and EGF-induced phosphorylation of CREB/ATF1 was barely detectable in MSK1-/- cells.	Tetradecanoylphorbol Acetate	17-20	activating transcription factor 1	Mus musculus	62-66
11018520-4	2000	In contrast, the TPA- and EGF-induced phosphorylation of CREB/ATF1 was barely detectable in MSK1-/- cells.	Tetradecanoylphorbol Acetate	17-20	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	92-96
11018469-2	2000	Phorbol myristoyl acetate (PMA) strongly stimulated phosphatidylcholine (PtdCho)-specific phospholipase D (PLD) activity in the C3H/10T1/2 Cl8 parental cell line, but not in Cl8 HAbetaC2-1 cells, indicating that full PLD activity in PMA-treated Cl8 cells is dependent on a functional interaction of alpha/betaPKC with RACK1.	Tetradecanoylphorbol Acetate	27-30	Receptor of activated protein kinase C 1	Drosophila melanogaster	318-323
9500517-10	1998	Enzymatically active as well as PMSF-blocked conventionally purified proteinase 3 interfered with phorbol myristate acetate-induced superoxide release.	Tetradecanoylphorbol Acetate	98-123	proteinase 3	Homo sapiens	69-81
11018469-8	2000	The present study shows: (1) PMA-stimulated PLD activity is dependent on a functional interaction between alpha/betaPKC and RACK1 in C3H/10T1/2 Cl8 fibroblasts; and (2) inhibition of PLD activity and PtdH formation did not reduce the cellular uptake and incorporation of labelled choline into PtdCho, indicating that these processes are not directly regulated by PtdCho-PLD activity in PMA-treated C3H/10T1/2 Cl8 fibroblasts.	Tetradecanoylphorbol Acetate	29-32	Receptor of activated protein kinase C 1	Drosophila melanogaster	124-129
11018470-2	2000	In SK-N-MC human neuroblastoma cells, phorbol ester (TPA) activation of PLD was enhanced by overexpressing myristoylated alanine-rich C kinase substrate (MARCKS).	Tetradecanoylphorbol Acetate	53-56	myristoylated alanine rich protein kinase C substrate	Homo sapiens	107-152
9548589-9	1998	The cPLA2 was activated by TPA, and appeared to be responsible for the majority of the specific release of AA observed in mouse keratinocytes treated with TPA.	Tetradecanoylphorbol Acetate	155-158	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	4-9
11018470-2	2000	In SK-N-MC human neuroblastoma cells, phorbol ester (TPA) activation of PLD was enhanced by overexpressing myristoylated alanine-rich C kinase substrate (MARCKS).	Tetradecanoylphorbol Acetate	53-56	myristoylated alanine rich protein kinase C substrate	Homo sapiens	154-160
10933732-6	2000	The vIRF-3 mRNA levels in BCBL-1 cells were increased upon 12-O-tetradecanoylphorbol-13-acetate treatment, with kinetics of expression similar to those of the early immediate genes.	Tetradecanoylphorbol Acetate	59-95	vIRF-3	Human gammaherpesvirus 8	4-10
9511724-8	1998	Long-term treatment with either the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) or bryostatin 1 inhibited levels of Dsg1 and Dsg3, but not Dsg2 in NHEKs and HaCaT cells.	Tetradecanoylphorbol Acetate	50-86	desmoglein 3	Homo sapiens	138-142
10944458-9	2000	Both hypoxia and phorbol-myristate-acetate enhanced Ang-2 mRNA levels in HEECs.	Tetradecanoylphorbol Acetate	17-42	angiopoietin 2	Homo sapiens	52-57
9511724-8	1998	Long-term treatment with either the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) or bryostatin 1 inhibited levels of Dsg1 and Dsg3, but not Dsg2 in NHEKs and HaCaT cells.	Tetradecanoylphorbol Acetate	50-86	desmoglein 2	Homo sapiens	152-156
9511724-8	1998	Long-term treatment with either the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) or bryostatin 1 inhibited levels of Dsg1 and Dsg3, but not Dsg2 in NHEKs and HaCaT cells.	Tetradecanoylphorbol Acetate	88-91	desmoglein 3	Homo sapiens	138-142
9511724-9	1998	Chronic TPA also decreased Dsg1 and Dsg3 mRNA levels in NHEKs, further supporting a role for PKC activation in the expression of the suprabasal Dsg1 and Dsg3.	Tetradecanoylphorbol Acetate	8-11	desmoglein 3	Homo sapiens	36-40
9511724-9	1998	Chronic TPA also decreased Dsg1 and Dsg3 mRNA levels in NHEKs, further supporting a role for PKC activation in the expression of the suprabasal Dsg1 and Dsg3.	Tetradecanoylphorbol Acetate	8-11	desmoglein 3	Homo sapiens	153-157
9446569-3	1998	MAP (ERK2) kinase activity (quantified by substrate phosphorylation) was increased by UTP, ATP, phorbol 12-myristate 13-acetate, ionomycin, and growth factors.	Tetradecanoylphorbol Acetate	96-127	mitogen activated protein kinase 1	Rattus norvegicus	5-9
10933807-3	2000	We have shown previously that phorbol ester (PMA) stimulation of endogenous PKC leads to activation of Na(+),K(+)-ATPase in cultured proximal tubule cells (OK cells) expressing the rodent Na(+), K(+)-ATPase alpha-subunit.	Tetradecanoylphorbol Acetate	45-48	protein kinase C beta	Homo sapiens	76-79
9473629-7	1998	Receptor binding studies using the OTR antagonist 125I-labeled ornithine vasotocin, and Western blot analyses of OTRs in MCF7 cells, showed that PMA and forskolin also increased the density of endogenous human oxytocin receptors.	Tetradecanoylphorbol Acetate	145-148	oxytocin receptor	Homo sapiens	35-38
10933807-8	2000	PMA treatment led to phosphorylation of the alpha-subunit by stimulation of PKC-beta, and the extent of this phosphorylation was greatly reduced in the S11A and S18A mutants.	Tetradecanoylphorbol Acetate	0-3	protein kinase C beta	Homo sapiens	76-84
9472709-5	1998	These results indicate that the inhibitory actions of TPA and PB on GJIC are cell-specific rather than connexin-specific and that TPA inhibits connexin43 and connexin32-mediated GJIC through a protein kinase C-dependent mechanism.	Tetradecanoylphorbol Acetate	130-133	gap junction protein, beta 1	Rattus norvegicus	158-168
10816571-9	2000	In addition, 12-O-tetradecanoylphorbol-13-acetate treatment of human umbilical vein endothelial cell stimulates the nuclear translocation of EDF-1.	Tetradecanoylphorbol Acetate	13-49	endothelial differentiation related factor 1	Homo sapiens	141-146
9515165-5	1998	Moreover, the PKC-activating phorbol ester, phorbol-12-myristate, 13-acetate (PMA) caused an increase in PDE-4 activity, similar to that observed in cells challenged with anti-CD3 monoclonal antibodies and which was not additive with cochallenge using anti-CD3 antibodies.	Tetradecanoylphorbol Acetate	78-81	CD3 antigen, epsilon polypeptide	Mus musculus	176-179
9515165-5	1998	Moreover, the PKC-activating phorbol ester, phorbol-12-myristate, 13-acetate (PMA) caused an increase in PDE-4 activity, similar to that observed in cells challenged with anti-CD3 monoclonal antibodies and which was not additive with cochallenge using anti-CD3 antibodies.	Tetradecanoylphorbol Acetate	78-81	CD3 antigen, epsilon polypeptide	Mus musculus	257-260
10911375-9	2000	In vitro studies of the proband"s purified fibrinogen revealed markedly abnormal thrombin-catalyzed polymerization and delayed fibrin clot lysis by tPA-activated plasmin.	Tetradecanoylphorbol Acetate	148-151	plasminogen	Homo sapiens	162-169
9472478-8	1998	One microM isoproterenol and 5 microM forskolin induced phosphorylation of connexin43, as did 16 nanomolar TPA.	Tetradecanoylphorbol Acetate	107-110	gap junction protein alpha 1	Homo sapiens	75-85
10930293-9	2000	These observations demonstrate that, C/EBPbeta and c-Jun contribute to the regulation of the TNF-alpha gene in normal macrophages following treatment with PMA.	Tetradecanoylphorbol Acetate	155-158	CCAAT enhancer binding protein beta	Homo sapiens	37-46
9472737-7	1998	Activation of PKC by phorbol 12-myristate 13-acetate (20 nM) decreased I(IsK) (gerbil: by 62 +/- 10%; rat: by 72 +/- 6%) in perforated-patch whole-cell recordings while the inactive analog, 4alphaPMA, had no effect.	Tetradecanoylphorbol Acetate	21-52	potassium voltage-gated channel subfamily E regulatory subunit 1	Rattus norvegicus	73-76
10818086-2	2000	The present studies demonstrate that the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induces translocation of protein kinase C (PKC) delta from the cytoplasm to mitochondria.	Tetradecanoylphorbol Acetate	55-91	protein kinase C delta	Homo sapiens	123-151
10818086-2	2000	The present studies demonstrate that the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induces translocation of protein kinase C (PKC) delta from the cytoplasm to mitochondria.	Tetradecanoylphorbol Acetate	93-96	protein kinase C delta	Homo sapiens	123-151
9443943-6	1998	The protein kinase C (PKC) inhibitor GF109203X enhanced the glutamate-induced current, and the PKC activator phorbol-12-myristate-13-acetate inhibited this current in the oocytes expressing mGluR5, but these compounds had little effect on mGluR1 function.	Tetradecanoylphorbol Acetate	109-140	glutamate receptor, ionotropic, kainate 1	Mus musculus	190-196
10818086-4	2000	The functional significance of this event is further supported by the demonstration that PKCdelta translocation is required for TPA-induced apoptosis.	Tetradecanoylphorbol Acetate	128-131	protein kinase C delta	Homo sapiens	89-97
10884368-9	2000	PMA-induced ROS generation was comparable in aortae from wild-type and eNOS(-/-) mice, but was attenuated in segments from gp91phox(-/-) mice.	Tetradecanoylphorbol Acetate	0-3	cytochrome b-245, beta polypeptide	Mus musculus	123-131
9425264-3	1997	The PGD synthase activity and the mRNA level of these cells increased 2.5 approximately 4.5- and 1.7 approximately 4.5-fold respectively when treated with 12-O-tetradecanoyl-phorbol-13-acetate at 0.1 microM for 72 h, indicating that the enzyme was inducible.	Tetradecanoylphorbol Acetate	155-192	phosphoglycerate dehydrogenase	Homo sapiens	4-7
9503684-5	1997	Furthermore, the frequency of T cells which produced IL-4, IL-5 and IFN-gamma stimulated with phorbol myristate acetate and ionomycin increased and reduced in parallel with MFI of EG2-positive cells.	Tetradecanoylphorbol Acetate	94-119	interleukin 5	Homo sapiens	59-63
10886243-7	2000	In accordance with this, CD80 and phorbol myristate acetate (PMA) (without anti-CD3 or calcium ionophore) were sufficient to induce production of IL-5 and IL-13, but not of IL-4.	Tetradecanoylphorbol Acetate	34-59	interleukin 5	Homo sapiens	146-150
9417811-6	1997	Exposure of osteoblasts to a high dose of phorbol myristoyl acetate (PMA) to deplete PKC activity abolished CGRP-mediated TNF-alpha suppression.	Tetradecanoylphorbol Acetate	69-72	calcitonin-related polypeptide alpha	Rattus norvegicus	108-112
10886243-7	2000	In accordance with this, CD80 and phorbol myristate acetate (PMA) (without anti-CD3 or calcium ionophore) were sufficient to induce production of IL-5 and IL-13, but not of IL-4.	Tetradecanoylphorbol Acetate	61-64	interleukin 5	Homo sapiens	146-150
10843688-4	2000	Porcine B7-1 was present on the surface of both B and T cells following stimulation with PMA/ionomycin.	Tetradecanoylphorbol Acetate	89-92	CD80 molecule	Homo sapiens	8-12
9405121-6	1997	Addition of SRIF reduced the GH release responses to two activators of PKC (100 microM dioctanoyl glycerol and 100 nM tetradecanoyl phorbol acetate) and to two ionophores (10 microM A23187 and 10 microM ionomycin).	Tetradecanoylphorbol Acetate	118-147	somatostatin 1	Gallus gallus	12-16
10871841-6	2000	TPA-induced MEK1/2 and Raf-1 phosphorylation were reduced in these cells.	Tetradecanoylphorbol Acetate	0-3	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	23-28
10871841-7	2000	The TPA-enhanced active Ras, and its association with Raf-1, were reduced.	Tetradecanoylphorbol Acetate	4-7	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	54-59
9497487-5	1997	Preincubation with two different PKC inhibitors, one specific for classical isotypes (alpha and beta I) Go6976, and one which inhibits both classical and non-classical isotypes, GF109203X, caused a complete block in cytoplasmic IL-2 accumulation when naive CD4 T cells were stimulated in the presence of CD2+CD28+phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	312-338	protein kinase C beta	Homo sapiens	33-36
10866046-5	2000	Activation of PKC by 12-O-tetradecanoyl-phorbol 13-acetate (TPA) caused a shift of both insulin granules and MLCK to the cell periphery, which was not reproduced by the adenylate cyclase activator, forskolin.	Tetradecanoylphorbol Acetate	21-58	myosin light chain kinase 3	Mus musculus	109-113
9497487-5	1997	Preincubation with two different PKC inhibitors, one specific for classical isotypes (alpha and beta I) Go6976, and one which inhibits both classical and non-classical isotypes, GF109203X, caused a complete block in cytoplasmic IL-2 accumulation when naive CD4 T cells were stimulated in the presence of CD2+CD28+phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	340-343	protein kinase C beta	Homo sapiens	33-36
10866046-5	2000	Activation of PKC by 12-O-tetradecanoyl-phorbol 13-acetate (TPA) caused a shift of both insulin granules and MLCK to the cell periphery, which was not reproduced by the adenylate cyclase activator, forskolin.	Tetradecanoylphorbol Acetate	60-63	myosin light chain kinase 3	Mus musculus	109-113
21528341-5	1997	More specifically, we observed: (a) increased secretion and/or activation of gelatinases A (MMP-2) and B (MMP-9) after exposure of 8 cell lines to 10(-6) M TPA; (b) increased activation of interstitial collagenase (MMP-1) caseinolysis after stimulation of 3 cancer cell lines with 10(-7) M TPA; and (c) increased activation of MMP-2 after exposure of 2 cell lines to 0.5 mM H3O2.	Tetradecanoylphorbol Acetate	156-159	matrix metallopeptidase 2	Homo sapiens	92-97
10866046-7	2000	Costimulation of the beta-cell by TPA and forskolin induced drastic translocation of insulin granules and MLCK to the cell periphery, resulting in enormous potentiation of insulin release.	Tetradecanoylphorbol Acetate	34-37	myosin light chain kinase 3	Mus musculus	106-110
21528341-5	1997	More specifically, we observed: (a) increased secretion and/or activation of gelatinases A (MMP-2) and B (MMP-9) after exposure of 8 cell lines to 10(-6) M TPA; (b) increased activation of interstitial collagenase (MMP-1) caseinolysis after stimulation of 3 cancer cell lines with 10(-7) M TPA; and (c) increased activation of MMP-2 after exposure of 2 cell lines to 0.5 mM H3O2.	Tetradecanoylphorbol Acetate	156-159	matrix metallopeptidase 2	Homo sapiens	327-332
11026574-9	2000	The results of transfections with either the K19 gene promoter or the heterologous thymidine kinase promoter and constructs containing mutated or deleted portions of the enhancer region show that the K19 ERE is responsible for the E2-dependent transactivation of the keratin 19 gene and for the synergism that is observed between E2 and TPA with both ER alpha and ER beta.	Tetradecanoylphorbol Acetate	337-340	keratin 19	Homo sapiens	200-203
9498574-5	1997	Pretreatment with tumor necrosis factor (TNF) or phorbol ester (TPA), which increases the Mn-SOD level, prevented the apoptosis.	Tetradecanoylphorbol Acetate	64-67	superoxide dismutase 2	Homo sapiens	90-96
11026574-9	2000	The results of transfections with either the K19 gene promoter or the heterologous thymidine kinase promoter and constructs containing mutated or deleted portions of the enhancer region show that the K19 ERE is responsible for the E2-dependent transactivation of the keratin 19 gene and for the synergism that is observed between E2 and TPA with both ER alpha and ER beta.	Tetradecanoylphorbol Acetate	337-340	keratin 19	Homo sapiens	267-277
10547001-0	1999	Evidence from studies with N-ethyl-maleimide and 12-O-tetradecanoylphorbol-13-acetate that AP-1 and CREB are involved in the glucocorticoid activation of TRH gene expression in hypothalamic cultures.	Tetradecanoylphorbol Acetate	49-85	thyrotropin releasing hormone	Rattus norvegicus	154-157
10779414-5	2000	Accordingly, the PKC activator phorbol myristate acetate up-regulated LAT expression.	Tetradecanoylphorbol Acetate	31-56	linker for activation of T cells	Homo sapiens	70-73
10547001-2	1999	NEM decreased while TPA increased TRH levels in rat hypothalamic culture, changes similar to their effects on CREB and Fos/Jun proteins in the AtT20 cell line.	Tetradecanoylphorbol Acetate	20-23	thyrotropin releasing hormone	Rattus norvegicus	34-37
10596452-9	1999	All these agents and phorbol myristate acetate (PMA) induce alpha 1b-adrenoceptor phosphorylation.	Tetradecanoylphorbol Acetate	48-51	adrenoceptor alpha 1B	Rattus norvegicus	60-81
9375654-12	1997	Furthermore, the mTAUT activity was not inhibited by the inactive phorbol ester 4alpha-phorbol 12,13-didecanoate but was inhibited significantly by the active phorbol ester phorbol 12-myristate 13-acetate, which was both concentration and time dependent.	Tetradecanoylphorbol Acetate	173-204	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	Mus musculus	17-22
10842315-1	2000	The tumor promoter phorbol 13-myristate 12-acetate (PMA), the best characterized protein kinase C agonist, frequently regulates gene expression via activation of Fos/Jun (AP-1) complexes.	Tetradecanoylphorbol Acetate	52-55	jun proto-oncogene	Mus musculus	171-175
9417865-4	1997	Consistent with macrophage specificity, HC gp-39 expression is also induced upon selective stimulation of the pluripotent promyelocytic leukemia cell line HL-60 toward the monocyte/macrophage lineage with vitamin D3 or phorbol 12-myristate 13-acetate (PMA), while treatments stimulating granulocyte and eosinophilic pathways do not induce expression.	Tetradecanoylphorbol Acetate	219-250	chitinase 3 like 1	Homo sapiens	40-48
9417865-4	1997	Consistent with macrophage specificity, HC gp-39 expression is also induced upon selective stimulation of the pluripotent promyelocytic leukemia cell line HL-60 toward the monocyte/macrophage lineage with vitamin D3 or phorbol 12-myristate 13-acetate (PMA), while treatments stimulating granulocyte and eosinophilic pathways do not induce expression.	Tetradecanoylphorbol Acetate	252-255	chitinase 3 like 1	Homo sapiens	40-48
9417865-5	1997	Furthermore, HC gp-39 expression levels correlate with the degree of morphological differentiation induced by PMA and vitamin D3 treatments.	Tetradecanoylphorbol Acetate	110-113	chitinase 3 like 1	Homo sapiens	13-21
10615432-7	1999	RESULTS: Epithelioid SMC, but not swirling SMC, secreted MMP-2 in response to uPA and tPA.	Tetradecanoylphorbol Acetate	86-89	matrix metallopeptidase 2	Rattus norvegicus	57-62
10522802-6	1999	PEP 1261 was also observed to inhibit the levels of H2O2, O2*-, MPO and lysosomal enzymes (p &lt; 0.05) as compared to PMA stimulated control rat neutrophils and neutrophils from arthritic rats.	Tetradecanoylphorbol Acetate	119-122	prolyl endopeptidase	Homo sapiens	0-3
10744726-5	2000	Moreover, we show that the sequence specific to the HER4 JM-a juxtamembrane region is sufficient to confer susceptibility to phorbol 12-myristate 13-acetate-induced cleavage of the HER2 receptor.	Tetradecanoylphorbol Acetate	125-156	erb-b2 receptor tyrosine kinase 4	Homo sapiens	52-56
10455189-10	1999	Phorbol 12-myristate 13-acetate also induced HEF1 tyrosine phosphorylation, and the protein kinase C inhibitor calphostin C completely inhibited both calcitonin- and phorbol 12-myristate 13-acetate-stimulated HEF1 phosphorylation.	Tetradecanoylphorbol Acetate	0-31	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	45-49
9393876-4	1997	In C3H 10T1/2 cells, p38/RK and its downstream kinase MAPKAP K-2 are activated by all stimuli used with the exception of TPA.	Tetradecanoylphorbol Acetate	121-124	mitogen-activated protein kinase 14	Mus musculus	21-24
9345026-5	1997	During the PMA-induced differentiation, cyclin E-associated cdk2 activity drops markedly.	Tetradecanoylphorbol Acetate	11-14	cyclin dependent kinase 2	Homo sapiens	60-64
9345026-6	1997	Furthermore, the amount of p27(Kip1) protein associated with cyclin E/cdk2 greatly increases 24 to 72 hours after PMA treatment.	Tetradecanoylphorbol Acetate	114-117	cyclin dependent kinase 2	Homo sapiens	70-74
10753198-7	2000	More detailed comparison of the responsiveness of SL2/sprd and SL5/sprd at Fl5 showed that these two inbred strains differed in their sensitivity to TPA-induced epidermal hyperplasia and that the dose of TPA required to produce a tumor response in SL5/sprd in comparison with that in SL2/sprd was 4-20 times higher.	Tetradecanoylphorbol Acetate	149-152	matrix metallopeptidase 10	Mus musculus	50-53
9420139-3	1997	METHODS AND RESULTS: We studied the effect of interleukin 7 (IL-7) on the expression of CD23 in normal PBT cells stimulated with PMA + Ca2.	Tetradecanoylphorbol Acetate	129-132	Fc epsilon receptor II	Homo sapiens	88-92
9367627-8	1997	Ca(2+)-independent PKC isoforms, rather than PKC alpha or beta, may thus be involved in PMA-induced cofilin dephosphorylation.	Tetradecanoylphorbol Acetate	88-91	cofilin 1	Homo sapiens	100-107
9367627-12	1997	Phosphatases 1 and/or 2A may thus control cofilin phosphorylation in resting cells and contribute to PMA-induced cofilin dephosphorylation.	Tetradecanoylphorbol Acetate	101-104	cofilin 1	Homo sapiens	113-120
9392422-11	1997	Based on a close kinetic correlation between PKC alpha translocation and ERK activation, and the effects of specific inhibitors, these findings suggest that translocation/activation of PKC alpha, and subsequent activation of the Raf-1/MEK/ERK MAPK cascade, represent key events in the transcriptional induction of LDL receptor gene by TPA in HepG2 cells.	Tetradecanoylphorbol Acetate	335-338	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	229-234
9367861-1	1997	Mobile lipid levels, IL-2R alpha expression and proliferation increased after treatment with PMA and ionomycin.	Tetradecanoylphorbol Acetate	93-96	interleukin 2 receptor subunit alpha	Homo sapiens	21-32
9367861-2	1997	PMA or ionomycin stimulation alone induced increased IL-2R alpha expression but not proliferation.	Tetradecanoylphorbol Acetate	0-3	interleukin 2 receptor subunit alpha	Homo sapiens	53-64
10455189-10	1999	Phorbol 12-myristate 13-acetate also induced HEF1 tyrosine phosphorylation, and the protein kinase C inhibitor calphostin C completely inhibited both calcitonin- and phorbol 12-myristate 13-acetate-stimulated HEF1 phosphorylation.	Tetradecanoylphorbol Acetate	0-31	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	209-213
10455189-10	1999	Phorbol 12-myristate 13-acetate also induced HEF1 tyrosine phosphorylation, and the protein kinase C inhibitor calphostin C completely inhibited both calcitonin- and phorbol 12-myristate 13-acetate-stimulated HEF1 phosphorylation.	Tetradecanoylphorbol Acetate	166-197	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	45-49
10455189-10	1999	Phorbol 12-myristate 13-acetate also induced HEF1 tyrosine phosphorylation, and the protein kinase C inhibitor calphostin C completely inhibited both calcitonin- and phorbol 12-myristate 13-acetate-stimulated HEF1 phosphorylation.	Tetradecanoylphorbol Acetate	166-197	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	209-213
10792503-3	2000	Activation of the human monoblastic leukaemia cell line, U937, by phorbol 12-myristate 13-acetate (PMA) increased the expression of CD14/CD86, and cytokine production.	Tetradecanoylphorbol Acetate	66-97	CD14 molecule	Homo sapiens	132-136
9341140-0	1997	Gastrin and phorbol 12-myristate 13-acetate regulate the human histidine decarboxylase promoter through Raf-dependent activation of extracellular signal-regulated kinase-related signaling pathways in gastric cancer cells.	Tetradecanoylphorbol Acetate	12-43	histidine decarboxylase	Homo sapiens	63-86
9341140-0	1997	Gastrin and phorbol 12-myristate 13-acetate regulate the human histidine decarboxylase promoter through Raf-dependent activation of extracellular signal-regulated kinase-related signaling pathways in gastric cancer cells.	Tetradecanoylphorbol Acetate	12-43	zinc fingers and homeoboxes 2	Homo sapiens	104-107
9341140-3	1997	Gastrin and phorbol 12-myristate 13-acetate (PMA) treatment of AGS-B cells was found to increase the phosphorylation of tyrosine residues of extracellular signal-regulated kinases (ERKs) 1 and 2 and increase ERK activity as determined by the in vitro phosphorylation of myelin basic protein.	Tetradecanoylphorbol Acetate	12-43	myelin basic protein	Homo sapiens	270-290
10792503-3	2000	Activation of the human monoblastic leukaemia cell line, U937, by phorbol 12-myristate 13-acetate (PMA) increased the expression of CD14/CD86, and cytokine production.	Tetradecanoylphorbol Acetate	66-97	CD86 molecule	Homo sapiens	137-141
9341140-3	1997	Gastrin and phorbol 12-myristate 13-acetate (PMA) treatment of AGS-B cells was found to increase the phosphorylation of tyrosine residues of extracellular signal-regulated kinases (ERKs) 1 and 2 and increase ERK activity as determined by the in vitro phosphorylation of myelin basic protein.	Tetradecanoylphorbol Acetate	45-48	myelin basic protein	Homo sapiens	270-290
10432309-5	1999	Our simulations show that there are significant differences in structure between the TpA step (where p=phosphate) and the ApA and ApT steps, where a large roll into the major groove at the TpA step appears to be an important factor in widening the minor groove at this position.	Tetradecanoylphorbol Acetate	189-192	glutamyl aminopeptidase	Homo sapiens	122-125
10792503-4	2000	PMA stimulation also increased the expression of both pro-caspase-8 and pro-caspase-3 in U937, but not apoptosis or intracellular caspase-3 activity.	Tetradecanoylphorbol Acetate	0-3	caspase 8	Homo sapiens	58-67
10792503-5	2000	PMA also increased the expression of X-chromosome-linked inhibitor of apoptosis protein (XIAP) in U937, suggesting an inhibitory action for XIAP on the caspase cascade in PMA-stimulated U937.	Tetradecanoylphorbol Acetate	0-3	caspase 8	Homo sapiens	152-159
9359417-11	1997	Cytochalasin D, but not colchicine, completely inhibited CCK-8- and PMA-induced p125(FAK) and paxillin phosphorylation.	Tetradecanoylphorbol Acetate	68-71	paxillin	Rattus norvegicus	94-102
10792503-7	2000	When a potent NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), was added to U937 cell culture in the presence of PMA, apoptosis was triggered by activation of caspase-3, which was induced by caspase-8 activation.	Tetradecanoylphorbol Acetate	121-124	caspase 8	Homo sapiens	199-208
9334853-2	1997	Naive CD4+CD45RA+ T-cells from human cord blood expressed CDw127 (IL-7R) at higher levels than adult CD4+ CD45RA+ T-cells and produced IL-2 and a small amount of IFN-gamma upon stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	194-197	interleukin 7 receptor	Homo sapiens	58-64
9334853-2	1997	Naive CD4+CD45RA+ T-cells from human cord blood expressed CDw127 (IL-7R) at higher levels than adult CD4+ CD45RA+ T-cells and produced IL-2 and a small amount of IFN-gamma upon stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	194-197	interleukin 7 receptor	Homo sapiens	66-71
10449779-6	1999	TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3.	Tetradecanoylphorbol Acetate	25-61	jun proto-oncogene	Mus musculus	123-127
10449779-6	1999	TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3.	Tetradecanoylphorbol Acetate	25-61	jun proto-oncogene	Mus musculus	152-156
10449779-6	1999	TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3.	Tetradecanoylphorbol Acetate	25-61	jun proto-oncogene	Mus musculus	152-156
9326269-7	1997	In contrast, the TPA-induced translocation of PKC epsilon was maintained after 3-6 h of treatment, and almost complete down-regulation occurred only after a 24-h treatment.	Tetradecanoylphorbol Acetate	17-20	protein kinase C, epsilon	Mus musculus	46-57
10792503-9	2000	The inhibitors of caspase-8 and caspase-3 mostly inhibited apoptosis of U937 treated with PMA in the presence of PDTC.	Tetradecanoylphorbol Acetate	90-93	caspase 8	Homo sapiens	18-27
9326269-8	1997	The observed TPA-induced inhibition of UTP- or ATP-stimulated phosphoinositide hydrolysis, therefore, correlated well with the extent of translocation of PKC epsilon.	Tetradecanoylphorbol Acetate	13-16	protein kinase C, epsilon	Mus musculus	154-165
10449779-6	1999	TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3.	Tetradecanoylphorbol Acetate	25-61	matrix metallopeptidase 13	Mus musculus	242-255
10449779-6	1999	TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3.	Tetradecanoylphorbol Acetate	63-66	jun proto-oncogene	Mus musculus	123-127
10449779-6	1999	TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3.	Tetradecanoylphorbol Acetate	63-66	jun proto-oncogene	Mus musculus	152-156
10449779-6	1999	TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3.	Tetradecanoylphorbol Acetate	63-66	jun proto-oncogene	Mus musculus	152-156
9299557-5	1997	However, A20 mutants that no longer associated with 14-3-3 proteins could still fully inhibit NF-kappaB activation induced by tumor necrosis factor, interleukin-1beta or phorbol 12-myristate 13-acetate, thus excluding a crucial role for 14-3-3 interaction in this A20 function.	Tetradecanoylphorbol Acetate	170-201	TNF alpha induced protein 3	Homo sapiens	9-12
9395008-1	1997	The purpose of this study is to elucidate the effect of interleukin-7 (IL-7) and soluble CD23 (sCD23) on Phorbol12 Myristate13 Acetate (PMA) activated CD4+ TCR alpha beta+ cells of HIV-1 infected subjects.	Tetradecanoylphorbol Acetate	105-134	Fc epsilon receptor II	Homo sapiens	89-93
10737590-2	2000	Treatment of NG108-15 cells with TPA (100 nM) for 48 h increased delta-opioid receptor mRNA levels, whereas different concentrations of forskolin induced a transient down-regulation of mRNA 5 h after treatment, followed by increased mRNA levels after 48 h. Reporter gene assays in transiently transfected NG108-15 cells in combination with electrophoretic mobility shift assays indicate that the increase of delta-opioid receptor mRNA after stimulation with TPA is mediated by transcription factor AP-1, which binds 355 bp upstream of the start codon within the gene promoter.	Tetradecanoylphorbol Acetate	33-36	jun proto-oncogene	Mus musculus	498-502
9395008-1	1997	The purpose of this study is to elucidate the effect of interleukin-7 (IL-7) and soluble CD23 (sCD23) on Phorbol12 Myristate13 Acetate (PMA) activated CD4+ TCR alpha beta+ cells of HIV-1 infected subjects.	Tetradecanoylphorbol Acetate	136-139	Fc epsilon receptor II	Homo sapiens	89-93
9315102-2	1997	Here, we have analysed AP-1 transcriptional activity in mouse keratinocytes treated with calcium and 12-O-tetradecanoyl phorbol-13-acetate (TPA), two agents that induce terminal differentiation of keratinocytes with different phenotypic consequences.	Tetradecanoylphorbol Acetate	101-138	jun proto-oncogene	Mus musculus	23-27
9315102-2	1997	Here, we have analysed AP-1 transcriptional activity in mouse keratinocytes treated with calcium and 12-O-tetradecanoyl phorbol-13-acetate (TPA), two agents that induce terminal differentiation of keratinocytes with different phenotypic consequences.	Tetradecanoylphorbol Acetate	140-143	jun proto-oncogene	Mus musculus	23-27
9315102-5	1997	In contrast, AP-1 reporter activity was increased in keratinocytes treated with TPA.	Tetradecanoylphorbol Acetate	80-83	jun proto-oncogene	Mus musculus	13-17
9315102-7	1997	Analysis of AP-1 protein expression in calcium- and TPA-treated keratinocytes demonstrated that only TPA increased the expression of c-Jun, while Jun B and Jun D were induced by both of these agents.	Tetradecanoylphorbol Acetate	101-104	jun proto-oncogene	Mus musculus	133-138
9299393-2	1997	The infectivity of HIV-1 from the cells stimulated with phorbol 12-myristate 13-acetate (PMA) was suppressed by pretreatment with N-myristoyl glycinal diethylacetal (N-Myr-GOA), a potent N-myristoylation inhibitor, and the blockage of myristoylation resulted in accumulation of immature gag precursors.	Tetradecanoylphorbol Acetate	56-87	Pr55(Gag)	Human immunodeficiency virus 1	287-290
9299393-2	1997	The infectivity of HIV-1 from the cells stimulated with phorbol 12-myristate 13-acetate (PMA) was suppressed by pretreatment with N-myristoyl glycinal diethylacetal (N-Myr-GOA), a potent N-myristoylation inhibitor, and the blockage of myristoylation resulted in accumulation of immature gag precursors.	Tetradecanoylphorbol Acetate	89-92	Pr55(Gag)	Human immunodeficiency virus 1	287-290
9300077-7	1997	The specificity of an inhibitory effect was confirmed by GnRH receptor-independent stimulation with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate or basic fibroblast growth factor.	Tetradecanoylphorbol Acetate	118-154	gonadotropin releasing hormone receptor	Homo sapiens	57-70
9276439-4	1997	An almost similar pattern of nuclear p42/44 MAP kinase stimulation is seen with TPA.	Tetradecanoylphorbol Acetate	80-83	cyclin-dependent kinase 20	Mus musculus	37-40
9271313-7	1997	CsA and FK506 strongly inhibited cellular IL-5 mRNA expression in response to phytohemagglutinin (PHA), or to phorbol myristate acetate (PMA), and/or calcium ionophore.	Tetradecanoylphorbol Acetate	110-135	interleukin 5	Homo sapiens	42-46
9271313-7	1997	CsA and FK506 strongly inhibited cellular IL-5 mRNA expression in response to phytohemagglutinin (PHA), or to phorbol myristate acetate (PMA), and/or calcium ionophore.	Tetradecanoylphorbol Acetate	137-140	interleukin 5	Homo sapiens	42-46
9257805-8	1997	In leukemic granulocytic HL60 and NB4 cells, downregulation of G alpha16 proteins was an early event (8 hours) in the process of neutrophil differentiation; in contrast, expression of G alpha16 proteins remained high during normal monocytic differentiation and in HL60 cells differentiating into monocytes with phorbol myristate acetate (PMA) or gamma-interferon (IFNgamma).	Tetradecanoylphorbol Acetate	311-336	G protein subunit alpha 15	Homo sapiens	63-72
9276765-0	1997	Effect of topically applied cyclooxygenase-2-selective inhibitors on arachidonic acid- and tetradecanoylphorbol acetate-induced dermal inflammation in the mouse.	Tetradecanoylphorbol Acetate	91-119	prostaglandin-endoperoxide synthase 2	Mus musculus	28-44
9276765-7	1997	The TPA-induced increase in 6-keto-PGF1 alpha was greatly inhibited by all COX-2 inhibitors while LTB4 was potentiated by both flosulide and L-745,337.	Tetradecanoylphorbol Acetate	4-7	prostaglandin-endoperoxide synthase 2	Mus musculus	75-80
9263207-4	1997	To study the role of sauvagine, cAMP, TRH and phorbol 12-myristate 13-acetate (PMA) in the regulation of POMC biosynthesis, the degree of incorporation of radioactive amino acids into the POMC protein was determined after treatment of the neurointermediate lobes with these secretagogues.	Tetradecanoylphorbol Acetate	79-82	proopiomelanocortin L homeolog	Xenopus laevis	105-109
9221921-5	1997	Incubation of cultures with the PKC activator, phorbol-12-myristate-13-acetate (PMA; 100 nM), caused temporal changes in AT2 receptor mRNA levels similar to those observed with NGF.	Tetradecanoylphorbol Acetate	47-78	angiotensin II receptor, type 2	Rattus norvegicus	121-124
9221921-5	1997	Incubation of cultures with the PKC activator, phorbol-12-myristate-13-acetate (PMA; 100 nM), caused temporal changes in AT2 receptor mRNA levels similar to those observed with NGF.	Tetradecanoylphorbol Acetate	80-83	angiotensin II receptor, type 2	Rattus norvegicus	121-124
9247594-5	1997	Indeed, we found that the expression of endothelial VAP-1 could be up-regulated in human tonsillar tissue with interleukin (IL)-1, IL-4, tumor necrosis factor (TNF-alpha), interferon (IFN)-gamma and lipopolysaccharide, whereas histamine, thrombin, dibutyryl cAMP, N-formyl-Met-Leu-Phe (fMLP) and phorbol 12-myristate 13-acetate (PMA) had no effect.	Tetradecanoylphorbol Acetate	296-327	amine oxidase copper containing 3	Homo sapiens	52-57
9254887-4	1997	Cotransfection of K14TAM67 with luciferase plasmid reporter DNAs produced inhibition of basal and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 and NF kappa B activity but had no effect on p53-dependent transcriptional activity.	Tetradecanoylphorbol Acetate	98-134	jun proto-oncogene	Mus musculus	149-153
9254887-4	1997	Cotransfection of K14TAM67 with luciferase plasmid reporter DNAs produced inhibition of basal and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 and NF kappa B activity but had no effect on p53-dependent transcriptional activity.	Tetradecanoylphorbol Acetate	136-139	jun proto-oncogene	Mus musculus	149-153
9254887-6	1997	This suggests that blocking TPA-induced AP-1- or NF kappa B-regulated gene expression by TAM67 inhibits TPA-induced progression.	Tetradecanoylphorbol Acetate	28-31	jun proto-oncogene	Mus musculus	40-44
9254887-6	1997	This suggests that blocking TPA-induced AP-1- or NF kappa B-regulated gene expression by TAM67 inhibits TPA-induced progression.	Tetradecanoylphorbol Acetate	104-107	jun proto-oncogene	Mus musculus	40-44
9254887-10	1997	These results suggest that the action of the dominant negative jun mutant on AP-1 and NF kappa B gene regulation results in complex alterations in the levels of downstream effector genes, such as the metalloproteinases, that effect TPA-induced cellular invasion.	Tetradecanoylphorbol Acetate	232-235	jun proto-oncogene	Mus musculus	77-81
9253802-4	1997	The acceleration of tPA-induced plasmin generation in the presence of low concentration of L-arginine, along with augmentation of in vitro fibrinogenolysis have been documented.	Tetradecanoylphorbol Acetate	20-23	plasminogen	Homo sapiens	32-39
9225005-10	1997	Furthermore, in vitro phosphorylation of p36-38 occurred in lysates of cells that were treated for 24 hr with PMA, but not in lysates of bryostatin-treated cells.	Tetradecanoylphorbol Acetate	110-113	linker for activation of T cells	Homo sapiens	41-47
9268491-5	1997	Similarly, when CBRH-7919 rat liver cancer cells were treated with phorbol 12-myristate 13-acetate, a proliferation stimulator of the cells, gamma-GT and Ca2+-dependent activities of PC-PLC and the expression of alpha-fetoprotein increased significantly.	Tetradecanoylphorbol Acetate	67-98	alpha-fetoprotein	Rattus norvegicus	212-229
9436464-7	1997	Although anti-CD28 costimulated naive T-cells treated with phorbol myristate acetate (PMA) instead of anti-CD3 mAb, a combination of PMA plus anti-CD9 mAb could not induce T-cell activation.	Tetradecanoylphorbol Acetate	59-84	CD28 molecule	Homo sapiens	14-18
9436464-7	1997	Although anti-CD28 costimulated naive T-cells treated with phorbol myristate acetate (PMA) instead of anti-CD3 mAb, a combination of PMA plus anti-CD9 mAb could not induce T-cell activation.	Tetradecanoylphorbol Acetate	86-89	CD28 molecule	Homo sapiens	14-18
9220345-10	1997	Acute or chronic exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA) or treatment with Ro-31-8220 showed that the stimulation of PI hydrolysis by PE, but not ET-1 or BK, was inhibited by activation of PKC.	Tetradecanoylphorbol Acetate	29-65	protein kinase C, delta	Rattus norvegicus	204-207
9220345-10	1997	Acute or chronic exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA) or treatment with Ro-31-8220 showed that the stimulation of PI hydrolysis by PE, but not ET-1 or BK, was inhibited by activation of PKC.	Tetradecanoylphorbol Acetate	67-70	protein kinase C, delta	Rattus norvegicus	204-207
9154841-4	1997	The appearance of transformed phenotypes induced by TPA in these cells correlated not with activation but rather with depletion of expressed PKC isoforms.	Tetradecanoylphorbol Acetate	52-55	protein kinase C, delta	Rattus norvegicus	141-144
9153199-4	1997	The PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA), but not the Ca2+ ionophore ionomycin, mimicked the rapid effect of GnRH-A upon PKCepsilon mRNA elevation.	Tetradecanoylphorbol Acetate	18-54	protein kinase C, epsilon	Mus musculus	141-151
9153199-4	1997	The PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA), but not the Ca2+ ionophore ionomycin, mimicked the rapid effect of GnRH-A upon PKCepsilon mRNA elevation.	Tetradecanoylphorbol Acetate	56-59	protein kinase C, epsilon	Mus musculus	141-151
9153199-9	1997	Western blot analysis revealed that GnRH-A and TPA stimulated (within 5 min) the activation and some degradation of PKCdelta and PKCepsilon.	Tetradecanoylphorbol Acetate	47-50	protein kinase C, epsilon	Mus musculus	129-139
9115222-3	1997	Here we demonstrate that PAF or phorbol 12-myristate 13-acetate (PMA) pretreatment inhibited wild type PAFR-induced PLC-mediated responses by approximately 90%, whereas these responses to the phosphorylation-deficient mPAFR were inhibited by approximately 50%, despite normal G protein coupling, suggesting a distal inhibitory locus.	Tetradecanoylphorbol Acetate	32-63	platelet activating factor receptor	Homo sapiens	103-107
9115222-3	1997	Here we demonstrate that PAF or phorbol 12-myristate 13-acetate (PMA) pretreatment inhibited wild type PAFR-induced PLC-mediated responses by approximately 90%, whereas these responses to the phosphorylation-deficient mPAFR were inhibited by approximately 50%, despite normal G protein coupling, suggesting a distal inhibitory locus.	Tetradecanoylphorbol Acetate	65-68	platelet activating factor receptor	Homo sapiens	103-107
9115222-4	1997	PAF and PMA, as well as a membrane permeable cyclic AMP analog, stimulated phosphorylation of PLCbeta3.	Tetradecanoylphorbol Acetate	8-11	phospholipase C beta 3	Homo sapiens	94-102
9115222-5	1997	A protein kinase C (PKC) inhibitor blocked phosphorylation of PLCbeta3 stimulated by PAF and PMA but not by cAMP.	Tetradecanoylphorbol Acetate	93-96	phospholipase C beta 3	Homo sapiens	62-70
9144344-6	1997	Human PTHrP(7-34) amide, at 10 nM, and 1 microM phorbol-12-myristate-13-acetate also significantly decreased DNA synthesis in human osteoblast-like cells.	Tetradecanoylphorbol Acetate	48-79	parathyroid hormone like hormone	Homo sapiens	6-11
9175723-9	1997	In coculture with hepatocytes, PMNs exposed to either flutamide, fmlp, or PMA alone caused a significant increase in release of alanine aminotransferase.	Tetradecanoylphorbol Acetate	74-77	glutamic--pyruvic transaminase	Homo sapiens	128-152
9142914-1	1997	The histidine decarboxylase (HDC) gene is regulated transcriptionally by gastrin and phorbol 12-myristate 13-acetate (PMA) through a protein kinase C (PKC)-related pathway.	Tetradecanoylphorbol Acetate	85-116	histidine decarboxylase	Homo sapiens	4-27
9142914-1	1997	The histidine decarboxylase (HDC) gene is regulated transcriptionally by gastrin and phorbol 12-myristate 13-acetate (PMA) through a protein kinase C (PKC)-related pathway.	Tetradecanoylphorbol Acetate	85-116	histidine decarboxylase	Homo sapiens	29-32
9142914-1	1997	The histidine decarboxylase (HDC) gene is regulated transcriptionally by gastrin and phorbol 12-myristate 13-acetate (PMA) through a protein kinase C (PKC)-related pathway.	Tetradecanoylphorbol Acetate	118-121	histidine decarboxylase	Homo sapiens	4-27
9142914-1	1997	The histidine decarboxylase (HDC) gene is regulated transcriptionally by gastrin and phorbol 12-myristate 13-acetate (PMA) through a protein kinase C (PKC)-related pathway.	Tetradecanoylphorbol Acetate	118-121	histidine decarboxylase	Homo sapiens	29-32
9147290-1	1997	GT1-7 cells respond to treatment with the phorbol ester, phorbol 12-myristate 13-acetate (PMA), with an inhibition of transcription of the proGnRH gene and decreases in GnRH mRNA levels.	Tetradecanoylphorbol Acetate	57-88	retinoic acid induced 1	Mus musculus	0-3
9247650-3	1997	We observed that LFA-1-expressing K562 cannot bind to intercellular adhesion molecule 1-coated surfaces when stimulated by phorbol 12-myristate 13-acetate (PMA), whereas the LFA-1-activating antibody KIM185 markedly enhanced adhesion.	Tetradecanoylphorbol Acetate	123-154	integrin subunit alpha L	Homo sapiens	17-22
10449779-6	1999	TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3.	Tetradecanoylphorbol Acetate	63-66	matrix metallopeptidase 13	Mus musculus	242-255
10449779-6	1999	TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3.	Tetradecanoylphorbol Acetate	68-104	jun proto-oncogene	Mus musculus	123-127
10449779-6	1999	TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3.	Tetradecanoylphorbol Acetate	68-104	jun proto-oncogene	Mus musculus	152-156
10449779-6	1999	TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3.	Tetradecanoylphorbol Acetate	68-104	jun proto-oncogene	Mus musculus	152-156
10482923-3	1999	Here, we have investigated the particular protein kinase C (PKC) isoform(s) responsible for the inhibition of P2Y1 and P2Y2 receptor-evoked inositol phosphate (IP) formation by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	177-208	purinergic receptor P2Y1	Bos taurus	110-114
10430658-10	1999	However, in vivo phosphorylation analysis showed that the TPA treatment reduced the phosphorylation levels of occludin, while the prolonged Ca(2+) starvation completely dephosphorylated the two occludin bands.	Tetradecanoylphorbol Acetate	58-61	occludin	Canis lupus familiaris	110-118
10397633-1	1999	Cellular distribution and activation by phorbol myristate acetate (PMA) of classical (alpha, betaI, betaII,gamma), novel (delta, epsilon, theta, eta), and atypical (zeta, iota) protein kinase C (PKC) isoforms were studied in cultured rat neonatal microglial and astroglial cells by Western blot analysis.	Tetradecanoylphorbol Acetate	67-70	endothelin receptor type A	Rattus norvegicus	60-63
10406459-0	1999	A dominant role for the Raf-MEK pathway in forskolin, 12-O-tetradecanoyl-phorbol acetate, and platelet-derived growth factor-induced CREB (cAMP-responsive element-binding protein) activation, uncoupled from serine 133 phosphorylation in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	54-88	midkine	Mus musculus	28-31
11360653-0	1999	[Phorbol-12-myristate-13-acetate and interferon-gamma synergistic induction of B7-1 expression in ovary carcinoma cells and immunological value].	Tetradecanoylphorbol Acetate	1-32	CD80 molecule	Homo sapiens	79-83
11360653-6	1999	The synergistic effect of PMA combined with IFN-gamma in the induction of B7-1 expression can be anatagonised by H7 [1-(5-isoquinolinesulfonyl)-2-methyl-Piperazine dihydrochloride].	Tetradecanoylphorbol Acetate	26-29	CD80 molecule	Homo sapiens	74-78
10366782-5	1999	Western blot analysis revealed that the induction of COX-2 by TPA or thapsigargin was inhibited by the two compounds in parallel with the inhibition of prostaglandin E2 production.	Tetradecanoylphorbol Acetate	62-65	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	53-58
10381170-6	1999	Expression of Tax, in addition to stimulation with phorbol myristate acetate and ionomycin, increased formation of the NRF1 complex in a gel-mobility shift assay, indicating that Tax association with NRF1 in vivo facilitates its DNA binding.	Tetradecanoylphorbol Acetate	51-76	nuclear respiratory factor 1	Homo sapiens	119-123
10381170-6	1999	Expression of Tax, in addition to stimulation with phorbol myristate acetate and ionomycin, increased formation of the NRF1 complex in a gel-mobility shift assay, indicating that Tax association with NRF1 in vivo facilitates its DNA binding.	Tetradecanoylphorbol Acetate	51-76	nuclear respiratory factor 1	Homo sapiens	200-204
10427686-7	1999	The CDO mRNA level in HepG2 cells was decreased after 2 h and reached a minimum 6 h-8 h after a phorbol 12-myristate 13-acetate (PMA) treatment, and then gradually returned to the basal level.	Tetradecanoylphorbol Acetate	96-127	cysteine dioxygenase type 1	Rattus norvegicus	4-7
10427686-7	1999	The CDO mRNA level in HepG2 cells was decreased after 2 h and reached a minimum 6 h-8 h after a phorbol 12-myristate 13-acetate (PMA) treatment, and then gradually returned to the basal level.	Tetradecanoylphorbol Acetate	129-132	cysteine dioxygenase type 1	Rattus norvegicus	4-7
10365914-7	1999	Analysis of the IGF-1 receptor (IGF-1r) and epidermal growth factor (EGFr) in the epidermis of TPA-treated HK1.IGF-1 transgenic and non-transgenic mice revealed that both receptors were activated (hyperphosphorylated on tyrosine residues), and the level of activation was higher in transgenic mice.	Tetradecanoylphorbol Acetate	95-98	insulin-like growth factor 1	Mus musculus	16-21
10208981-4	1999	TPA stimulated the secretion of HGF by ESC in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-3	hepatocyte growth factor	Homo sapiens	32-35
10208981-5	1999	TPA also induced the transcription of HGF mRNA by ESC.	Tetradecanoylphorbol Acetate	0-3	hepatocyte growth factor	Homo sapiens	38-41
10208981-7	1999	TPA-stimulated production of HGF was partially inhibited by the addition of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine or sphingosine.	Tetradecanoylphorbol Acetate	0-3	hepatocyte growth factor	Homo sapiens	29-32
10410383-1	1999	Topical application of TPA to a murine ear induced an edema that was accompanied by eicosanoid biosynthesis and an early enhancement of prostaglandin H synthase 2 (PGHS-2) expression.	Tetradecanoylphorbol Acetate	23-26	prostaglandin-endoperoxide synthase 2	Mus musculus	136-162
10410383-1	1999	Topical application of TPA to a murine ear induced an edema that was accompanied by eicosanoid biosynthesis and an early enhancement of prostaglandin H synthase 2 (PGHS-2) expression.	Tetradecanoylphorbol Acetate	23-26	prostaglandin-endoperoxide synthase 2	Mus musculus	164-170
10410383-2	1999	PGHS-2 induction may be correlated with the time-course of TPA-induced edema formation.	Tetradecanoylphorbol Acetate	59-62	prostaglandin-endoperoxide synthase 2	Mus musculus	0-6
10410383-8	1999	This study suggests that AA release and/or subsequent metabolism by PGHS may be involved in the induction of PGHS-2 expression in murine TPA- and AA-induced ear oedema.	Tetradecanoylphorbol Acetate	137-140	prostaglandin-endoperoxide synthase 2	Mus musculus	109-115
10206975-5	1999	When the N-terminal region of Kir2.3 was replaced with that of Kir2.1, another member in the Kir2 family that is insensitive to PMA, the chimerical channel lost its PMA sensitivity.	Tetradecanoylphorbol Acetate	128-131	potassium inwardly rectifying channel subfamily J member 2 L homeolog	Xenopus laevis	63-69
10209029-5	1999	Phosphorylated alpha-adducin accumulated in the membrane ruffling area of Madin-Darby canine kidney (MDCK) epithelial cells and the leading edge of scattering cells during the action of tetradecanoylphorbol-13-acetate (TPA) or hepatocyte growth factor (HGF).	Tetradecanoylphorbol Acetate	219-222	adducin 1	Canis lupus familiaris	15-28
10209306-0	1999	Continuous phosphorylation of GAP-43 and MARCKS by long-term TPA treatment in SK-N-SH human neuroblastoma cells.	Tetradecanoylphorbol Acetate	61-64	myristoylated alanine rich protein kinase C substrate	Homo sapiens	41-47
10209306-3	1999	Cells were treated with 70 nM TPA for 15 min, 17 or 72 h. Phosphorylation of MARCKS and GAP-43 was elevated throughout 72 h of TPA.	Tetradecanoylphorbol Acetate	30-33	myristoylated alanine rich protein kinase C substrate	Homo sapiens	77-83
10209306-3	1999	Cells were treated with 70 nM TPA for 15 min, 17 or 72 h. Phosphorylation of MARCKS and GAP-43 was elevated throughout 72 h of TPA.	Tetradecanoylphorbol Acetate	127-130	myristoylated alanine rich protein kinase C substrate	Homo sapiens	77-83
10209306-4	1999	The magnitude and peptidic sites of phosphorylation in GAP-43 and MARCKS were similar after all TPA treatments.	Tetradecanoylphorbol Acetate	96-99	myristoylated alanine rich protein kinase C substrate	Homo sapiens	66-72
10221543-5	1999	Both p42/p44 MAP kinase activation and IL-6 synthesis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C-activating phorbol ester, were reduced by PD98059.	Tetradecanoylphorbol Acetate	65-101	cyclin-dependent kinase 20	Mus musculus	5-8
10221543-5	1999	Both p42/p44 MAP kinase activation and IL-6 synthesis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C-activating phorbol ester, were reduced by PD98059.	Tetradecanoylphorbol Acetate	65-101	mitogen-activated protein kinase 3	Mus musculus	9-12
10221543-5	1999	Both p42/p44 MAP kinase activation and IL-6 synthesis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C-activating phorbol ester, were reduced by PD98059.	Tetradecanoylphorbol Acetate	103-106	cyclin-dependent kinase 20	Mus musculus	5-8
10221543-5	1999	Both p42/p44 MAP kinase activation and IL-6 synthesis induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C-activating phorbol ester, were reduced by PD98059.	Tetradecanoylphorbol Acetate	103-106	mitogen-activated protein kinase 3	Mus musculus	9-12
10098498-11	1999	AVP and TPA, but not A23187, induced an increase in activity and tyrosine phosphorylation of p42 MAPK, together with a molecular weight shift, consistent with phosphorylation, of cytosolic PLA2.	Tetradecanoylphorbol Acetate	8-11	mitogen activated protein kinase 1	Rattus norvegicus	93-101
10098498-12	1999	AVP- or TPA-induced activation and tyrosine phosphorylation of p42 MAPK were completely blocked by down-regulation of PKCalpha, betaI, epsilon, and delta, but still occurred, together with the cytosolic PLA2 mobility shift, in the absence of external Ca2+.	Tetradecanoylphorbol Acetate	8-11	mitogen activated protein kinase 1	Rattus norvegicus	63-71
10085148-3	1999	Treatment of neonatal cardiac myocytes with the hypertrophic agonist 12-O-tetradecanoylphorbol-13-acetate or phenylephrine increased expression of Glut1 mRNA relative to Glut4 mRNA.	Tetradecanoylphorbol Acetate	69-105	solute carrier family 2 member 4	Homo sapiens	170-175
10085148-5	1999	Stimulation of the cells with 12-O-tetradecanoylphorbol-13-acetate or phenylephrine induced transcription from the Glut1 promoter, which was inhibited by cotransfection with the mitogen-activated protein kinase phosphatases CL100 and MKP-3.	Tetradecanoylphorbol Acetate	30-66	dual specificity phosphatase 6	Homo sapiens	234-239
10037704-9	1999	C/EBPbeta and C/EBPdelta inhibit both TPA- and C/EBPalpha-dependent promoter activation, indicating functional differences among C/EBP family members.	Tetradecanoylphorbol Acetate	38-41	CCAAT enhancer binding protein beta	Homo sapiens	0-9
10051531-5	1999	Marked or slight activation, respectively, of p44/42 MAPK or p38 was also seen after 10-min treatment with 12-O-tetradecanoylphorbol-13-acetate, but c-Jun NH2-terminal kinase activation did not occur.	Tetradecanoylphorbol Acetate	107-143	interferon induced protein 44	Homo sapiens	46-49
9931304-1	1999	Phosphorylation of p67phox was shown to increase two- to three-fold upon stimulation by PMA, N-formylmethionyl-leucylphenylalanine or serum-opsonized zymosan.	Tetradecanoylphorbol Acetate	88-91	neutrophil cytosolic factor 2	Homo sapiens	19-26
9990043-6	1999	Treatment of polyps with the ks1-inducing phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in reduced binding of nuclear proteins to the ks1 cis regulatory region.	Tetradecanoylphorbol Acetate	56-92	zinc finger protein 382	Homo sapiens	29-32
9990043-6	1999	Treatment of polyps with the ks1-inducing phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in reduced binding of nuclear proteins to the ks1 cis regulatory region.	Tetradecanoylphorbol Acetate	56-92	zinc finger protein 382	Homo sapiens	154-157
9990043-6	1999	Treatment of polyps with the ks1-inducing phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in reduced binding of nuclear proteins to the ks1 cis regulatory region.	Tetradecanoylphorbol Acetate	94-97	zinc finger protein 382	Homo sapiens	29-32
9990043-6	1999	Treatment of polyps with the ks1-inducing phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in reduced binding of nuclear proteins to the ks1 cis regulatory region.	Tetradecanoylphorbol Acetate	94-97	zinc finger protein 382	Homo sapiens	154-157
10064335-6	1999	Induction of AP-1 by the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is essential to tumor promotion.	Tetradecanoylphorbol Acetate	54-90	jun proto-oncogene	Mus musculus	13-17
10064335-6	1999	Induction of AP-1 by the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is essential to tumor promotion.	Tetradecanoylphorbol Acetate	92-95	jun proto-oncogene	Mus musculus	13-17
10064335-12	1999	We propose that this results in attenuation in the induction of the AP-1 transcription factor by TPA.	Tetradecanoylphorbol Acetate	97-100	jun proto-oncogene	Mus musculus	68-72
10064335-13	1999	Because AP-1 induction by TPA is obligatory for mouse skin promotion, we propose this as an essential component of the mechanism of DER prevention of mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	26-29	jun proto-oncogene	Mus musculus	8-12
9891065-8	1999	TPA-induced activation of the SRE was partially inhibited by dominant negative c-Raf, ERK1, or ERK2, and constitutively active mutants of PKC-alpha and PKC-epsilon activated the transactivation domain of Elk-1.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 3	Mus musculus	86-90
9891065-8	1999	TPA-induced activation of the SRE was partially inhibited by dominant negative c-Raf, ERK1, or ERK2, and constitutively active mutants of PKC-alpha and PKC-epsilon activated the transactivation domain of Elk-1.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, epsilon	Mus musculus	152-163
9891065-9	1999	TPA-induced activation of the SRE was also partially inhibited by a dominant-negative MEKK1.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 1	Mus musculus	86-91
9891065-10	1999	Furthermore, TPA treatment of serum-starved NIH 3T3 cells led to phosphorylation of SEK1, and constitutively active mutants of PKC-alpha and PKC-epsilon activated the transactivation domain of c-Jun, a major substrate of JNK.	Tetradecanoylphorbol Acetate	13-16	protein kinase C, epsilon	Mus musculus	141-152
9891065-10	1999	Furthermore, TPA treatment of serum-starved NIH 3T3 cells led to phosphorylation of SEK1, and constitutively active mutants of PKC-alpha and PKC-epsilon activated the transactivation domain of c-Jun, a major substrate of JNK.	Tetradecanoylphorbol Acetate	13-16	jun proto-oncogene	Mus musculus	193-198
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	CD19 molecule	Homo sapiens	210-214
9927065-7	1999	Immunofluorescence for beta-galactosidase demonstrated that TPA caused a significant increase in the percentage of beta-galactosidase-positive areas in 12:1 and 4:1 mixtures.	Tetradecanoylphorbol Acetate	60-63	galactosidase beta 1	Homo sapiens	23-41
9873047-5	1999	In HeLa cells, transiently expressed epitope-tagged RLPK can be strongly induced by epidermal growth factor, serum, and phorbol 12-myristate 13-acetate, but only moderately up-regulated by tumor necrosis factor-alpha and other stress-related stimuli.	Tetradecanoylphorbol Acetate	120-151	ribosomal protein S6 kinase A5	Homo sapiens	52-56
10226573-0	1999	A novel protein (p10) induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and other hyperplasiogenic tumor-promoting and non-promoting agents in murine epidermis.	Tetradecanoylphorbol Acetate	33-70	S100 calcium binding protein A10 (calpactin)	Mus musculus	17-20
10226573-0	1999	A novel protein (p10) induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and other hyperplasiogenic tumor-promoting and non-promoting agents in murine epidermis.	Tetradecanoylphorbol Acetate	72-75	S100 calcium binding protein A10 (calpactin)	Mus musculus	17-20
9179864-4	1997	The proDYN mRNA level began to increase 1 h, then reached and remained at a peak 3-6 h after stimulation by forskolin or PMA.	Tetradecanoylphorbol Acetate	121-124	prodynorphin	Rattus norvegicus	4-10
9179864-5	1997	proDYN mRNA levels in forskolin treated cells decreased slightly from their peak after 9 h of treatment, whereas the level of proDYN mRNA returned to the basal level in PMA-treated cells.	Tetradecanoylphorbol Acetate	169-172	prodynorphin	Rattus norvegicus	126-132
9179864-9	1997	Calcium influx through both L- and N-type calcium channels and Ca2+/calmodulin-dependent protein kinase II appear to be involved in the increase of proDYN mRNA levels induced by either forskolin or PMA.	Tetradecanoylphorbol Acetate	198-201	prodynorphin	Rattus norvegicus	148-154
9107303-10	1997	After activation with phorbol myristate acetate and ionomycin, the half-life of IL-5 mRNA was 2.6 h in HSB-2 cells and 4.0 h in T cells prepared from human blood.	Tetradecanoylphorbol Acetate	22-47	interleukin 5	Homo sapiens	80-84
9087164-3	1997	We show here that LFA-1-mediated adhesion of TAM2D2 T-cell hybridoma cells to ICAM-1 can in fact be induced by direct activation of G-proteins using AIF-4, to the same extent as by using PMA or Mn2+.	Tetradecanoylphorbol Acetate	187-190	intercellular adhesion molecule 1	Mus musculus	78-84
9045724-7	1997	Analysis of the levels of mRNA and protein derived from various 3" UTR deletion mutants indicated that all mutants were translated effectively and that differences in gene expression in response to TPA were attributable to changes in GAP-43 mRNA stability.	Tetradecanoylphorbol Acetate	198-201	growth associated protein 43	Rattus norvegicus	234-240
9099897-9	1997	Treatment of LNCaP and PC-3 cells with the phorbol ester 12-O-tetradecanoylphorbol (TPA) caused the same effect on mAAT activity and mRNA level as prolactin.	Tetradecanoylphorbol Acetate	84-87	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	115-119
10702271-7	2000	Activation of Pyk2 via the muscarinic and nicotinic receptors using carbachol or via intracellular Ca(2+) rise using ionomycin/phorbol myristate acetate promoted survival in the absence of IL-7.	Tetradecanoylphorbol Acetate	127-152	PTK2 protein tyrosine kinase 2 beta	Mus musculus	14-18
9119069-2	1997	Using luciferase assays with rat 3Y1 cells, we found that Rac1 is integrated downstream of Ras in the TRE (TPA response element) activation pathway.	Tetradecanoylphorbol Acetate	107-110	Rac family small GTPase 1	Rattus norvegicus	58-62
9067514-4	1997	This phenomenon was observed after ligation of CD28 combined with anti-CD3 or phorbol myristate acetate (PMA), but also after allogeneic stimulation and after activation by CD40 and anti-CD3.	Tetradecanoylphorbol Acetate	78-103	CD28 molecule	Homo sapiens	47-51
10529599-5	1999	RESULTS: Mean fluorescent intensity (MFI) of CR3 and LFA1-beta stimulated by PMA and ionomycin was significantly higher than that of the unstimulated control.	Tetradecanoylphorbol Acetate	77-80	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	45-48
9067514-4	1997	This phenomenon was observed after ligation of CD28 combined with anti-CD3 or phorbol myristate acetate (PMA), but also after allogeneic stimulation and after activation by CD40 and anti-CD3.	Tetradecanoylphorbol Acetate	105-108	CD28 molecule	Homo sapiens	47-51
10708478-2	2000	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), acting via its cellular receptor protein kinase C(PKC), induces these cells to acquire a monocytic phenotype.	Tetradecanoylphorbol Acetate	18-54	protein kinase C beta	Homo sapiens	112-115
9066513-5	1997	When endothelial cell were incubated with neutrophils stimulated by fMLP or phorbol myristate acetate, the amount of elastase in the medium and endothelial cell damage was further enhanced.	Tetradecanoylphorbol Acetate	76-101	elastase, neutrophil expressed	Homo sapiens	117-125
10529599-5	1999	RESULTS: Mean fluorescent intensity (MFI) of CR3 and LFA1-beta stimulated by PMA and ionomycin was significantly higher than that of the unstimulated control.	Tetradecanoylphorbol Acetate	77-80	integrin subunit alpha L	Homo sapiens	53-57
9858570-3	1999	In contrast, TPA-resistant TUR and HL-525 cell variants deficient in PKCbeta failed to respond to activators of PKC with the induction of SAPK.	Tetradecanoylphorbol Acetate	13-16	protein kinase C beta	Homo sapiens	69-76
9858570-3	1999	In contrast, TPA-resistant TUR and HL-525 cell variants deficient in PKCbeta failed to respond to activators of PKC with the induction of SAPK.	Tetradecanoylphorbol Acetate	13-16	protein kinase C beta	Homo sapiens	69-72
9858570-4	1999	A direct role for PKCbeta in TPA-induced SAPK activity in TUR and HL-525 cells that stably express PKCbeta was confirmed.	Tetradecanoylphorbol Acetate	29-32	protein kinase C beta	Homo sapiens	18-25
9858570-4	1999	A direct role for PKCbeta in TPA-induced SAPK activity in TUR and HL-525 cells that stably express PKCbeta was confirmed.	Tetradecanoylphorbol Acetate	29-32	protein kinase C beta	Homo sapiens	99-106
9858570-5	1999	We showed that TPA induced the association of PKCbeta with MEK kinase 1 (MEKK-1), an upstream effector of the SAPK/ERK kinase 1 (SEK1)--&gt;SAPK cascade.	Tetradecanoylphorbol Acetate	15-18	protein kinase C beta	Homo sapiens	46-53
9858570-5	1999	We showed that TPA induced the association of PKCbeta with MEK kinase 1 (MEKK-1), an upstream effector of the SAPK/ERK kinase 1 (SEK1)--&gt;SAPK cascade.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	59-71
9306153-0	1997	Ouabain effects on activated lymphocytes: augmentation of CD25 expression on TPA-stimulated cells and of CD69 on PHA-and TPA-stimulated cells.	Tetradecanoylphorbol Acetate	77-80	interleukin 2 receptor subunit alpha	Homo sapiens	58-62
9306153-0	1997	Ouabain effects on activated lymphocytes: augmentation of CD25 expression on TPA-stimulated cells and of CD69 on PHA-and TPA-stimulated cells.	Tetradecanoylphorbol Acetate	121-124	CD69 molecule	Homo sapiens	105-109
9306153-4	1997	Conversely, cultures activated by TPA and OUA showed an increased expression of CD25.	Tetradecanoylphorbol Acetate	34-37	interleukin 2 receptor subunit alpha	Homo sapiens	80-84
9858570-5	1999	We showed that TPA induced the association of PKCbeta with MEK kinase 1 (MEKK-1), an upstream effector of the SAPK/ERK kinase 1 (SEK1)--&gt;SAPK cascade.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	73-79
10708478-2	2000	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), acting via its cellular receptor protein kinase C(PKC), induces these cells to acquire a monocytic phenotype.	Tetradecanoylphorbol Acetate	56-59	protein kinase C beta	Homo sapiens	112-115
10851292-3	1999	Prolactin and 12-O-tetra-decanoylphorbol 13-acetate (TPA) increased the mAAT mRNA level twofold to fourfold.	Tetradecanoylphorbol Acetate	53-56	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	72-76
10708478-6	2000	Thus, the present studies provide strong evidence that the beta isoform of PKC plays a critical role in TPA-induced HL60 monocytic differentiation.	Tetradecanoylphorbol Acetate	104-107	protein kinase C beta	Homo sapiens	75-78
10851292-5	1999	The effects of both prolactin and TPA on mAAT mRNA were eliminated by downregulation of PKC.	Tetradecanoylphorbol Acetate	34-37	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	41-45
10692485-7	2000	In contrast, RGS2 mRNA was rapidly and dose dependently increased (395 +/- 24% peak, 45 min) by Ang II but returned to baseline level by 6 to 8 h. Phorbol-12-myristate-13-acetate, a PKC activator, robustly increased RGS2.	Tetradecanoylphorbol Acetate	147-178	regulator of G protein signaling 2	Homo sapiens	13-17
10851292-7	1999	The 59 untranslated region of the precursor form (pmAAT) of the mAAT gene contains five sequences that are homologous to the consensus TPA response elements (TRE).	Tetradecanoylphorbol Acetate	135-138	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	51-55
10851292-12	1999	Moreover, because both prolactin and TPA induced PKC activity, and because the effects of prolactin and TPA were eliminated when PKC was downregulated, we postulate that the prolactin effect on mAAT expression is mediated via the diacylglycerol PKC signal transduction pathway in rat lateral prostate and human prostate cancer cells.	Tetradecanoylphorbol Acetate	104-107	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	194-198
9188092-0	1997	Phorbol 12-myristate 13-acetate down-regulates Na,K-ATPase independent of its protein kinase C site: decrease in basolateral cell surface area.	Tetradecanoylphorbol Acetate	0-31	ATPase Na+/K+ transporting subunit alpha 1 L homeolog	Xenopus laevis	50-58
9095665-4	1997	IL-5 production by activated T-lymphocytes which are known to play a major role in chronic GVHD was upregulated when stimulated by PMA + ionomycin.	Tetradecanoylphorbol Acetate	131-134	interleukin 5	Homo sapiens	0-4
10692485-7	2000	In contrast, RGS2 mRNA was rapidly and dose dependently increased (395 +/- 24% peak, 45 min) by Ang II but returned to baseline level by 6 to 8 h. Phorbol-12-myristate-13-acetate, a PKC activator, robustly increased RGS2.	Tetradecanoylphorbol Acetate	147-178	regulator of G protein signaling 2	Homo sapiens	216-220
10579584-6	1999	Phorbol-12-myristate-13-acetate blocked the induction of p38 mitogen-activated protein kinase activity and specific inhibition of this kinase by SB 203580 attenuated serum deprivation-induced apoptosis.	Tetradecanoylphorbol Acetate	0-31	mitogen-activated protein kinase 14	Mus musculus	57-60
10692485-10	2000	Actinomycin D treatment inhibited both Ang II- and phorbol-12-myristate-13-acetate-stimulated RGS2 up-regulation, suggesting activation of transcription by these agonists.	Tetradecanoylphorbol Acetate	51-82	regulator of G protein signaling 2	Homo sapiens	94-98
9013627-2	1997	COX-2 is known to be induced by cytokines and the skin tumor promoter 12-tetradecanoylphorbol-13-myristate (TPA).	Tetradecanoylphorbol Acetate	108-111	prostaglandin-endoperoxide synthase 2	Mus musculus	0-5
10367292-8	1999	In tPA, 50 and 100 ng/mL bFGF increased PGI2 production from 1.98 +/- 0.14 to 3.5 +/- 1.05 and 3.96 +/- 0.46 (p &lt; 0.02).	Tetradecanoylphorbol Acetate	3-6	fibroblast growth factor 2	Ovis aries	25-29
10723268-4	2000	Furthermore, auranofin did not affect the COX-1 protein level, but inhibited the TPA-induced expression of COX-2 protein.	Tetradecanoylphorbol Acetate	81-84	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	107-112
10367292-11	1999	We conclude that PGI2 production is augmented by bFGF in UA, pPA and tPA, by VEGF in UA, and by EGF in tPA during ovine pregnancy.	Tetradecanoylphorbol Acetate	69-72	fibroblast growth factor 2	Ovis aries	49-53
9003008-9	1997	Moreover, the phorbol ester phorbol 12-myristate 13-acetate mimicked most of the effects of AngII in BAC and decreased both AT2-binding sites and mRNA on PC12W cells, indicating that the hormonal regulation of both AT1 and AT2 receptors is mediated through protein kinase C activation.	Tetradecanoylphorbol Acetate	28-59	angiotensin II receptor, type 1a	Rattus norvegicus	215-218
9003008-9	1997	Moreover, the phorbol ester phorbol 12-myristate 13-acetate mimicked most of the effects of AngII in BAC and decreased both AT2-binding sites and mRNA on PC12W cells, indicating that the hormonal regulation of both AT1 and AT2 receptors is mediated through protein kinase C activation.	Tetradecanoylphorbol Acetate	28-59	angiotensin II receptor, type 2	Rattus norvegicus	223-226
10723268-5	2000	Therefore, it was suggested that auranofin inhibited PGE2 production by inhibiting the COX-2 protein induction in TPA-stimulated macrophages.	Tetradecanoylphorbol Acetate	114-117	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	87-92
9190210-6	1997	Elf-1 has less effect in conjunction with PMA/ionomycin, but by itself activates the promoter 12-fold.	Tetradecanoylphorbol Acetate	42-45	E74 like ETS transcription factor 1	Homo sapiens	0-5
9067628-7	1997	We report here that erythropoietin, inositolphosphate-glycan, and 12-O-tetradecanoyl-phorbol-13-acetate activated only the p44 form (erk-1) of MAP kinase and the Raf-1 protein.	Tetradecanoylphorbol Acetate	66-103	interferon induced protein 44	Homo sapiens	123-126
9067628-7	1997	We report here that erythropoietin, inositolphosphate-glycan, and 12-O-tetradecanoyl-phorbol-13-acetate activated only the p44 form (erk-1) of MAP kinase and the Raf-1 protein.	Tetradecanoylphorbol Acetate	66-103	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	162-167
9885948-4	1998	Treatment of transfected cells with 0.1 microM 12-O-tetradecanoylphorbol 13-acetate (TPA) elicited a 5-6-fold increase in TH gene proximal promoter activity.	Tetradecanoylphorbol Acetate	47-83	tyrosine hydroxylase	Rattus norvegicus	122-124
10723268-9	2000	Auranofin (10 microM) strongly inhibited the production of PGE2 and NO, and the induction of COX-2 protein and NOS protein by TPA.	Tetradecanoylphorbol Acetate	126-129	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	93-98
9885948-4	1998	Treatment of transfected cells with 0.1 microM 12-O-tetradecanoylphorbol 13-acetate (TPA) elicited a 5-6-fold increase in TH gene proximal promoter activity.	Tetradecanoylphorbol Acetate	85-88	tyrosine hydroxylase	Rattus norvegicus	122-124
9885948-5	1998	Mutagenesis of the THCRE2 sequence diminished TPA-responsiveness of the TH gene promoter by approximately 50%.	Tetradecanoylphorbol Acetate	46-49	tyrosine hydroxylase	Rattus norvegicus	19-21
10699922-1	2000	Using isoenzyme-specific antibodies, we have performed an immunoblot analysis of the PKC isoenzyme pattern during the course of TPA-induced tumor promotion in the epidermis of NMRI mice.	Tetradecanoylphorbol Acetate	128-131	protein kinase C, beta	Mus musculus	85-88
9885948-6	1998	Minimal promoter constructs driven by a single copy of the region of the TH gene that encodes the THCRE2 (from -117 to -59) were also responsive to TPA.	Tetradecanoylphorbol Acetate	148-151	tyrosine hydroxylase	Rattus norvegicus	73-75
9852137-10	1998	Down-regulation of PKC by prolonged treatment with phorbol 12-myristate 13-acetate (PMA) also inhibited induction of MnSOD by anticancer drugs, indicating an important role of PKC in MnSOD signaling by these agents.	Tetradecanoylphorbol Acetate	51-82	superoxide dismutase 2	Homo sapiens	117-122
9852137-10	1998	Down-regulation of PKC by prolonged treatment with phorbol 12-myristate 13-acetate (PMA) also inhibited induction of MnSOD by anticancer drugs, indicating an important role of PKC in MnSOD signaling by these agents.	Tetradecanoylphorbol Acetate	51-82	superoxide dismutase 2	Homo sapiens	183-188
9852137-10	1998	Down-regulation of PKC by prolonged treatment with phorbol 12-myristate 13-acetate (PMA) also inhibited induction of MnSOD by anticancer drugs, indicating an important role of PKC in MnSOD signaling by these agents.	Tetradecanoylphorbol Acetate	84-87	superoxide dismutase 2	Homo sapiens	117-122
9852137-10	1998	Down-regulation of PKC by prolonged treatment with phorbol 12-myristate 13-acetate (PMA) also inhibited induction of MnSOD by anticancer drugs, indicating an important role of PKC in MnSOD signaling by these agents.	Tetradecanoylphorbol Acetate	84-87	superoxide dismutase 2	Homo sapiens	183-188
9088892-7	1997	Induction of fibronectin expression was also obtained using the PKC-activating phorbolester Phorbol-12-myristat-13-acetat (PMA) which mimicks glucose-induced PKC activation.	Tetradecanoylphorbol Acetate	123-126	protein kinase C delta	Homo sapiens	64-67
9088892-7	1997	Induction of fibronectin expression was also obtained using the PKC-activating phorbolester Phorbol-12-myristat-13-acetat (PMA) which mimicks glucose-induced PKC activation.	Tetradecanoylphorbol Acetate	123-126	protein kinase C delta	Homo sapiens	158-161
9015756-6	1997	The expression of c-src, c-fms, and macrophage colony stimulating factor (M-CSF) was induced by TPA treatment; however, TPA-induced M-CSF gene transcription was attenuated by the subsequent addition of 1,25-(OH)2D3.	Tetradecanoylphorbol Acetate	96-99	colony stimulating factor 1 receptor	Homo sapiens	25-30
9015756-6	1997	The expression of c-src, c-fms, and macrophage colony stimulating factor (M-CSF) was induced by TPA treatment; however, TPA-induced M-CSF gene transcription was attenuated by the subsequent addition of 1,25-(OH)2D3.	Tetradecanoylphorbol Acetate	120-123	colony stimulating factor 1 receptor	Homo sapiens	25-30
9010457-2	1997	In this model, L-10 cells moved outward from the cell islands mainly as a localized coherent sheet of cells when stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	129-165	ribosomal protein L10	Homo sapiens	15-19
9010457-2	1997	In this model, L-10 cells moved outward from the cell islands mainly as a localized coherent sheet of cells when stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	167-170	ribosomal protein L10	Homo sapiens	15-19
9885438-5	1998	On the other hand, TNF selectively induced tyrosine phosphorylation of p42, and PMA selectively induced that of p44 and p42.	Tetradecanoylphorbol Acetate	80-83	interferon induced protein 44	Homo sapiens	112-115
10699922-3	2000	The immune signals of all TPA-sensitive PKC isoforms were moderately and reversibly attenuated upon a single TPA treatment.	Tetradecanoylphorbol Acetate	26-29	protein kinase C, beta	Mus musculus	40-43
9837745-4	1998	These B cells expressed p40 and p35 mRNA, and phorbol myristate acetate (PMA) stimulation strongly enhanced p40 and p70 production.	Tetradecanoylphorbol Acetate	46-71	interleukin 9	Homo sapiens	108-111
10699922-3	2000	The immune signals of all TPA-sensitive PKC isoforms were moderately and reversibly attenuated upon a single TPA treatment.	Tetradecanoylphorbol Acetate	109-112	protein kinase C, beta	Mus musculus	40-43
9837745-4	1998	These B cells expressed p40 and p35 mRNA, and phorbol myristate acetate (PMA) stimulation strongly enhanced p40 and p70 production.	Tetradecanoylphorbol Acetate	73-76	interleukin 9	Homo sapiens	108-111
10699922-6	2000	Specific PKC activity (related to tissue weight) was 40-50% lower in TPA-treated as compared with control epidermis whereby no clearcut difference was found between single and chronic TPA treatment.	Tetradecanoylphorbol Acetate	69-72	protein kinase C, beta	Mus musculus	9-12
9290125-6	1997	In addition to PKC activation, active oxygen species production, and c-jun induction, our data suggest that TPA treatment induces cellular transformation by other unknown routes, because some tested compounds have an inhibitory effect on TPA-induced transformation but have no or a slight inhibitory effect on PKC activation, active oxygen species production, and c-jun induction.	Tetradecanoylphorbol Acetate	108-111	jun proto-oncogene	Mus musculus	69-74
9290125-6	1997	In addition to PKC activation, active oxygen species production, and c-jun induction, our data suggest that TPA treatment induces cellular transformation by other unknown routes, because some tested compounds have an inhibitory effect on TPA-induced transformation but have no or a slight inhibitory effect on PKC activation, active oxygen species production, and c-jun induction.	Tetradecanoylphorbol Acetate	108-111	jun proto-oncogene	Mus musculus	364-369
9812903-8	1998	Phorbol esters (TPA, 50 ng/mL) stimulated MMP-9 activity by 50%, and fluvastatin inhibited this enhanced activity up to 50% in both mouse and human macrophages.	Tetradecanoylphorbol Acetate	16-19	matrix metallopeptidase 9	Mus musculus	42-47
10662601-4	2000	Electrophoretic mobility shift assay (EMSA) revealed that VT modulated AP-1 binding activity in a concentration- and time-dependent manner when using a synchronous model in which VT was added concurrently with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) to EL-4 cells.	Tetradecanoylphorbol Acetate	210-241	jun proto-oncogene	Mus musculus	71-75
8977246-5	1996	In contrast, treatment with phorbol 12,13-myristic acetate (PMA) led to a reduction in steady-state levels and activity of both betaARK and GRK6.	Tetradecanoylphorbol Acetate	60-63	G protein-coupled receptor kinase 6	Homo sapiens	140-144
8977246-7	1996	In contrast, PMA and calcium ionophore treatment significantly elevated GRK6 protein levels, while decreasing betaARK expression.	Tetradecanoylphorbol Acetate	13-16	G protein-coupled receptor kinase 6	Homo sapiens	72-76
8955209-1	1996	We have analyzed the induction of the receptor for the anaphylatoxic peptide C3a (C3aR) by the immunomodulator IFN-gamma, the phorbol ester PMA, and dibutyryl cAMP (Bt2cAMP) in comparison with the C5a receptor (C5aR, CD88).	Tetradecanoylphorbol Acetate	140-143	complement C3a receptor 1	Homo sapiens	82-86
10662601-4	2000	Electrophoretic mobility shift assay (EMSA) revealed that VT modulated AP-1 binding activity in a concentration- and time-dependent manner when using a synchronous model in which VT was added concurrently with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) to EL-4 cells.	Tetradecanoylphorbol Acetate	243-246	jun proto-oncogene	Mus musculus	71-75
8955209-4	1996	In contrast, PMA did not increase specific 125I-hC3a binding, and actually antagonized C3aR induction by IFN-gamma.	Tetradecanoylphorbol Acetate	13-16	complement C3a receptor 1	Homo sapiens	87-91
10711350-6	2000	alpha-Fluoromethylhistidine, a suicide substrate of L-histidine decarboxylase (HDC), suppressed the thapsigargin (30 nM)- and TPA (30 nM)-induced histamine production.	Tetradecanoylphorbol Acetate	126-129	histidine decarboxylase	Mus musculus	52-77
9798919-3	1998	A twofold increase in content of tPA mRNA was observed with bFGF but not with TGF-beta1.	Tetradecanoylphorbol Acetate	33-36	fibroblast growth factor 2	Rattus norvegicus	60-64
10711350-6	2000	alpha-Fluoromethylhistidine, a suicide substrate of L-histidine decarboxylase (HDC), suppressed the thapsigargin (30 nM)- and TPA (30 nM)-induced histamine production.	Tetradecanoylphorbol Acetate	126-129	histidine decarboxylase	Mus musculus	79-82
8943287-7	1996	Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA; &gt;8 h) reduced IRS-1 content and down-regulated the novel PKC-delta isoform.	Tetradecanoylphorbol Acetate	20-56	protein kinase C delta	Homo sapiens	123-132
8943287-7	1996	Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA; &gt;8 h) reduced IRS-1 content and down-regulated the novel PKC-delta isoform.	Tetradecanoylphorbol Acetate	58-61	protein kinase C delta	Homo sapiens	123-132
9914781-2	1998	TPA-induced inhibition of DNA synthesis was augmented by overexpression of the eta and delta isoforms, but rescued by the dominant-negative and antisense eta isoforms.	Tetradecanoylphorbol Acetate	0-3	endothelin receptor type A	Mus musculus	79-82
8943287-8	1996	Bryostatin 1 inhibited TPA-induced depletion of both IRS-1 and PKC-delta expression in MCF-7 cells.	Tetradecanoylphorbol Acetate	23-26	protein kinase C delta	Homo sapiens	63-72
9914781-2	1998	TPA-induced inhibition of DNA synthesis was augmented by overexpression of the eta and delta isoforms, but rescued by the dominant-negative and antisense eta isoforms.	Tetradecanoylphorbol Acetate	0-3	endothelin receptor type A	Mus musculus	154-157
10711350-8	2000	Both thapsigargin (30 nM) and TPA (30 nM) induced phosphorylation of p44/p42 MAP kinase and p38 MAP kinase.	Tetradecanoylphorbol Acetate	30-33	mitogen-activated protein kinase 3	Mus musculus	69-72
10711350-8	2000	Both thapsigargin (30 nM) and TPA (30 nM) induced phosphorylation of p44/p42 MAP kinase and p38 MAP kinase.	Tetradecanoylphorbol Acetate	30-33	cyclin-dependent kinase 20	Mus musculus	73-76
10711350-8	2000	Both thapsigargin (30 nM) and TPA (30 nM) induced phosphorylation of p44/p42 MAP kinase and p38 MAP kinase.	Tetradecanoylphorbol Acetate	30-33	mitogen-activated protein kinase 14	Mus musculus	92-95
10711350-10	2000	PD98059, a specific inhibitor of MEK-1 which phosphorylates p44/p42 MAP kinase, strongly suppressed both the thapsigargin (30 nM)- and TPA (30 nM)-induced histamine production, whereas SB203580, a specific inhibitor of p38 MAP kinase, inhibited them only partially.	Tetradecanoylphorbol Acetate	135-138	mitogen-activated protein kinase kinase 1	Mus musculus	33-38
9822802-7	1998	Incubation with a cAMP analogue (8-bromo-cAMP, 8Br-cAMP) or with a PKC activator (12-O-tetradecanoylphorbol-13-acetate, TPA) increased TRH mRNA levels after 1 and 2 h, respectively.	Tetradecanoylphorbol Acetate	82-118	thyrotropin releasing hormone	Homo sapiens	135-138
9822802-10	1998	The stimulatory effect of 10(-7) M TPA on TRH mRNA levels was additive to that of dexamethasone; in contrast, coincubation with 10(-3) M 8-Br-cAMP and dexamethasone diminished the stimulatory effect of both drugs.	Tetradecanoylphorbol Acetate	35-38	thyrotropin releasing hormone	Homo sapiens	42-45
8938103-4	1996	The results demonstrate that cytoplasmic CD23 level was significantly augmented by costimulation with PMA + Ca2 plus IL-7 (1000 U/ml).	Tetradecanoylphorbol Acetate	102-105	Fc epsilon receptor II	Homo sapiens	41-45
10711350-10	2000	PD98059, a specific inhibitor of MEK-1 which phosphorylates p44/p42 MAP kinase, strongly suppressed both the thapsigargin (30 nM)- and TPA (30 nM)-induced histamine production, whereas SB203580, a specific inhibitor of p38 MAP kinase, inhibited them only partially.	Tetradecanoylphorbol Acetate	135-138	mitogen-activated protein kinase 3	Mus musculus	60-63
10711350-10	2000	PD98059, a specific inhibitor of MEK-1 which phosphorylates p44/p42 MAP kinase, strongly suppressed both the thapsigargin (30 nM)- and TPA (30 nM)-induced histamine production, whereas SB203580, a specific inhibitor of p38 MAP kinase, inhibited them only partially.	Tetradecanoylphorbol Acetate	135-138	cyclin-dependent kinase 20	Mus musculus	64-67
10711350-10	2000	PD98059, a specific inhibitor of MEK-1 which phosphorylates p44/p42 MAP kinase, strongly suppressed both the thapsigargin (30 nM)- and TPA (30 nM)-induced histamine production, whereas SB203580, a specific inhibitor of p38 MAP kinase, inhibited them only partially.	Tetradecanoylphorbol Acetate	135-138	mitogen-activated protein kinase 14	Mus musculus	219-222
8989914-4	1996	Northern analysis of mRNA isolated from cultures treated with TPA (1 microgram/mL) showed that a single treatment of TPA produced a sevenfold increase in PGHS-2 mRNA by 1 h that decreased by 6 h after treatment.	Tetradecanoylphorbol Acetate	62-65	prostaglandin-endoperoxide synthase 2	Mus musculus	154-160
10711350-12	2000	The other MEK-1 inhibitor, U-0126, also inhibited both the thapsigargin- and TPA-induced histamine production in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	77-80	mitogen-activated protein kinase kinase 1	Mus musculus	10-15
8989914-4	1996	Northern analysis of mRNA isolated from cultures treated with TPA (1 microgram/mL) showed that a single treatment of TPA produced a sevenfold increase in PGHS-2 mRNA by 1 h that decreased by 6 h after treatment.	Tetradecanoylphorbol Acetate	117-120	prostaglandin-endoperoxide synthase 2	Mus musculus	154-160
9834970-5	1998	Pyridaben is the most potent of the four inhibitors not only for NADH: ubiquinone oxidoreductase activity (bovine heart enzyme) and TPA-induced ornithine decarboxylase activity and mRNA steady state level but also for TPA-induced reactive oxygen species.	Tetradecanoylphorbol Acetate	132-135	ornithine decarboxylase 1	Homo sapiens	144-167
8989914-5	1996	PGHS-2 protein levels were elevated threefold by 3 h and remained elevated through 9 h. Downregulation of PKC with a second TPA treatment 15 h after the first resulted in diminished induction of PGHS-2 expression.	Tetradecanoylphorbol Acetate	124-127	prostaglandin-endoperoxide synthase 2	Mus musculus	0-6
8989914-5	1996	PGHS-2 protein levels were elevated threefold by 3 h and remained elevated through 9 h. Downregulation of PKC with a second TPA treatment 15 h after the first resulted in diminished induction of PGHS-2 expression.	Tetradecanoylphorbol Acetate	124-127	prostaglandin-endoperoxide synthase 2	Mus musculus	195-201
10679579-3	2000	Two phorbol esters, 4-beta-phorbol 12-myristate-13-acetate (PMA) and 4-beta-phorbol 12,13-dibutyrate (PDBu); the cGMP-dependent PK activators sodium nitroprusside (SNP) and S-nitrosoglutathione (SNOG); and the PP inhibitor okadaic acid (OA) reduced the amplitude of the GABA-induced currents, whilst the PK inhibitor staurosporine potentiated it.	Tetradecanoylphorbol Acetate	60-63	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	128-130
8939915-6	1996	Clostridium botulinum C3 exoenzyme completely inhibited both EP3 agonist- and TPA-induced neurite retraction when microinjected into the cells, indicating that the morphological effect of the EP3B receptor is dependent on Rho activity.	Tetradecanoylphorbol Acetate	78-81	prostaglandin E receptor 3	Rattus norvegicus	192-196
8939949-8	1996	COX-2 synthesis was induced by PMA (100 nM) or serum stimulation in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	31-34	cytochrome c oxidase II, mitochondrial	Mus musculus	0-5
10640752-4	2000	We found that surface expression and promoter activity of PECAM-1 in myeloid cells are regulated by modulators of NF-kappa B, including TNF-alpha, PMA, and pyrrolidine dithiocarbamate.	Tetradecanoylphorbol Acetate	147-150	platelet and endothelial cell adhesion molecule 1	Homo sapiens	58-65
9756922-5	1998	However, transcript and enzyme activity levels of core 2 GlcNAc-transferase (C2GnT) were significantly down-regulated during TPA treatment.	Tetradecanoylphorbol Acetate	125-128	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	50-75
9756922-5	1998	However, transcript and enzyme activity levels of core 2 GlcNAc-transferase (C2GnT) were significantly down-regulated during TPA treatment.	Tetradecanoylphorbol Acetate	125-128	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	77-82
8895335-4	1996	In contrast, 12-O-tetradecanoyl-13-phorbol-acetate (TPA) and epidermal growth factor, which induce proliferation and dedifferentiation of those cells by activation of the protein kinase C and the protein tyrosine kinase cascade, respectively, lead to a weaker expression of NGFI-B mRNA.	Tetradecanoylphorbol Acetate	52-55	nuclear receptor subfamily 4 group A member 1	Canis lupus familiaris	274-280
9756922-6	1998	Following transfection and constitutive expression of full-length exogenous C2GnT transcript, C2GnT enzyme activities were maintained at high levels even after TPA treatment and down-regulation of cell surface sLex antigen expression by TPA was completely abolished.	Tetradecanoylphorbol Acetate	160-163	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	76-81
10784405-2	2000	In the present study, we report that the expression of trkA was also induced by several other differentiation inducers, including 1alpha, 25-dihydroxyvitamin D3 (Vit D3), 1-beta-D-arabinofuranosyl cytosine (Ara-C), sodium butyrate (NaBut), and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	244-275	neurotrophic receptor tyrosine kinase 1	Homo sapiens	55-59
9756922-6	1998	Following transfection and constitutive expression of full-length exogenous C2GnT transcript, C2GnT enzyme activities were maintained at high levels even after TPA treatment and down-regulation of cell surface sLex antigen expression by TPA was completely abolished.	Tetradecanoylphorbol Acetate	160-163	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	94-99
9756922-6	1998	Following transfection and constitutive expression of full-length exogenous C2GnT transcript, C2GnT enzyme activities were maintained at high levels even after TPA treatment and down-regulation of cell surface sLex antigen expression by TPA was completely abolished.	Tetradecanoylphorbol Acetate	237-240	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	76-81
9756922-6	1998	Following transfection and constitutive expression of full-length exogenous C2GnT transcript, C2GnT enzyme activities were maintained at high levels even after TPA treatment and down-regulation of cell surface sLex antigen expression by TPA was completely abolished.	Tetradecanoylphorbol Acetate	237-240	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	94-99
9024981-1	1996	The effects of phorbol 12-myristate 13-acetate (PMA) on the activities of phospholipase D (PLD3), mitogen-activated protein kinase (ERK), and c-Jun N-terminal kinase (JNK) were studied in Jurkat, a human T cell line, and EL4, a murine T-cell line.	Tetradecanoylphorbol Acetate	48-51	phospholipase D family member 3	Homo sapiens	91-95
8930166-5	1996	Our pharmacological study suggests that, in neutrophil-like HL-60 cells, the signaling pathways leading to PMA-stimulated O2- generation appear to involve PKC, MAPK, phospholipase A2, arachidonic acid, PSP 1 and 2a and PTP.	Tetradecanoylphorbol Acetate	107-110	protein tyrosine phosphatase receptor type U	Homo sapiens	219-222
10784405-2	2000	In the present study, we report that the expression of trkA was also induced by several other differentiation inducers, including 1alpha, 25-dihydroxyvitamin D3 (Vit D3), 1-beta-D-arabinofuranosyl cytosine (Ara-C), sodium butyrate (NaBut), and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	277-280	neurotrophic receptor tyrosine kinase 1	Homo sapiens	55-59
8824276-3	1996	In the present study, we examined the effects of phorbol 12-myristate 13-acetate, a potent PKC activator, on the ligand-induced transcriptional activation of the CYP1A1 gene and cellular function of the AhR in human HepG2 101L cells.	Tetradecanoylphorbol Acetate	49-80	aryl hydrocarbon receptor	Homo sapiens	203-206
9763144-4	1998	PMA pretreatment of calvariae greatly blocked IL-6 mRNA induction by a subsequent dose of PMA and decreased induction by PTH and forskolin to a much lesser extent.	Tetradecanoylphorbol Acetate	0-3	parathyroid hormone	Mus musculus	121-124
10784405-3	2000	Interestingly, RA in combination with NaBut or PMA synergistically induced cellular differentiation as well as the expression of trkA in KG-1 cells.	Tetradecanoylphorbol Acetate	47-50	neurotrophic receptor tyrosine kinase 1	Homo sapiens	129-133
10636851-1	2000	Human involucrin (hINV) mRNA level and promoter activity increase when keratinocytes are treated with the differentiating agent, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	129-165	inversin	Homo sapiens	18-22
9877207-6	1998	ERalpha/E2 also induced a two-fold potentiation of TPA-mediated expression of beta-galactosidase under the control of TREs in HeLa cells but not in HEK-293 cells.	Tetradecanoylphorbol Acetate	51-54	galactosidase beta 1	Homo sapiens	78-96
9733711-5	1998	Northern blot analysis showed that phorbol 12-myristate 13-acetate increased the expression of Hs-CUL-3 mRNA in a concentration- and time-dependent manner, and this increase was inhibited by sodium salicylate.	Tetradecanoylphorbol Acetate	35-66	cullin 3	Homo sapiens	95-103
8873607-6	1996	TPA of skeletal SR at low and high Ca demonstrates that C12E8 induces aggregation of ATPase monomers and small oligomers.	Tetradecanoylphorbol Acetate	0-3	dynein axonemal heavy chain 8	Homo sapiens	85-91
8873607-9	1996	Thus the TPA results provide a simple physical explanation for the functional effects: C12E8 inhibits the ATPase when it aggregates the enzyme (skeletal SR at high and low Ca; cardiac SR at high Ca), and the detergent activates when it dissociates ATPase oligomers (cardiac SR at low Ca).	Tetradecanoylphorbol Acetate	9-12	dynein axonemal heavy chain 8	Homo sapiens	106-112
8873607-9	1996	Thus the TPA results provide a simple physical explanation for the functional effects: C12E8 inhibits the ATPase when it aggregates the enzyme (skeletal SR at high and low Ca; cardiac SR at high Ca), and the detergent activates when it dissociates ATPase oligomers (cardiac SR at low Ca).	Tetradecanoylphorbol Acetate	9-12	dynein axonemal heavy chain 8	Homo sapiens	248-254
8894616-6	1996	Human lymphocytes when pre-treated with 10 ng/ml TPA had a 3 times higher spontaneous natural killer activity against K562 cells and an increased expression of CD69.	Tetradecanoylphorbol Acetate	49-52	CD69 molecule	Homo sapiens	160-164
9733767-1	1998	The 173-base pair proximal promoter of SPRR1A is necessary and sufficient for regulated expression in primary keratinocytes induced to differentiate either by increasing extracellular calcium or by 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	198-234	small proline rich protein 1A	Homo sapiens	39-45
9733767-1	1998	The 173-base pair proximal promoter of SPRR1A is necessary and sufficient for regulated expression in primary keratinocytes induced to differentiate either by increasing extracellular calcium or by 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	236-239	small proline rich protein 1A	Homo sapiens	39-45
10636851-1	2000	Human involucrin (hINV) mRNA level and promoter activity increase when keratinocytes are treated with the differentiating agent, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	167-170	inversin	Homo sapiens	18-22
8890958-0	1996	Localization of the 12-O-tetradecanoylphorbol-13-acetate response of the human ornithine decarboxylase promoter to the TATA box.	Tetradecanoylphorbol Acetate	20-56	ornithine decarboxylase 1	Homo sapiens	79-102
8890958-1	1996	In a previous study, we narrowed the region of the human ornithine decarboxylase (ODC) promoter responsive to 12-O-tetradecanoylphorbol-13-acetate (TPA) to nt -42 to +54 around the transcription initiation site (Kim YJ, Pan H, Verma AK, Mol Carcinog 10:169-179, 1994).	Tetradecanoylphorbol Acetate	110-146	ornithine decarboxylase 1	Homo sapiens	57-80
10636851-10	2000	Synergistic promoter activation (&gt;/=100-fold) is observed when PKCepsilon- or -eta-transfected cells are treated with TPA.	Tetradecanoylphorbol Acetate	121-124	endothelin receptor type A	Homo sapiens	82-85
8890958-1	1996	In a previous study, we narrowed the region of the human ornithine decarboxylase (ODC) promoter responsive to 12-O-tetradecanoylphorbol-13-acetate (TPA) to nt -42 to +54 around the transcription initiation site (Kim YJ, Pan H, Verma AK, Mol Carcinog 10:169-179, 1994).	Tetradecanoylphorbol Acetate	110-146	ornithine decarboxylase 1	Homo sapiens	82-85
8890958-1	1996	In a previous study, we narrowed the region of the human ornithine decarboxylase (ODC) promoter responsive to 12-O-tetradecanoylphorbol-13-acetate (TPA) to nt -42 to +54 around the transcription initiation site (Kim YJ, Pan H, Verma AK, Mol Carcinog 10:169-179, 1994).	Tetradecanoylphorbol Acetate	148-151	ornithine decarboxylase 1	Homo sapiens	57-80
10644517-4	2000	Further studies show that NaCl-inducible ERK1 and ERK2 (ERK1/2) activation is a consequence of cPKC and nPKC activation, because either downregulation with 12-O-tetradecanoylphorbol 13-acetate or selective inhibition of cPKC and nPKC by GF-109203X and rottlerin largely inhibited the stimulation of ERK1/2 phosphorylation by NaCl.	Tetradecanoylphorbol Acetate	156-192	mitogen-activated protein kinase 3	Mus musculus	41-45
8890958-1	1996	In a previous study, we narrowed the region of the human ornithine decarboxylase (ODC) promoter responsive to 12-O-tetradecanoylphorbol-13-acetate (TPA) to nt -42 to +54 around the transcription initiation site (Kim YJ, Pan H, Verma AK, Mol Carcinog 10:169-179, 1994).	Tetradecanoylphorbol Acetate	148-151	ornithine decarboxylase 1	Homo sapiens	82-85
8890958-2	1996	Here we report defining the role of the TATA box in TPA-induced transcription from the -42/+54 ODC promoter fragment.	Tetradecanoylphorbol Acetate	52-55	ornithine decarboxylase 1	Homo sapiens	95-98
8890958-3	1996	A transversion mutation at the third position of the TATA box (TATAAGT--&gt;TAAAAGT) reduced TPA responsiveness of the reporter construct -42/+54 ODC-Luc by 49%.	Tetradecanoylphorbol Acetate	93-96	ornithine decarboxylase 1	Homo sapiens	146-149
8890958-10	1996	These results indicate that TPA modulation of the general transcription machinery may play a role in the TPA-activated transcription of the human ODC promoter.	Tetradecanoylphorbol Acetate	28-31	ornithine decarboxylase 1	Homo sapiens	146-149
8890958-10	1996	These results indicate that TPA modulation of the general transcription machinery may play a role in the TPA-activated transcription of the human ODC promoter.	Tetradecanoylphorbol Acetate	105-108	ornithine decarboxylase 1	Homo sapiens	146-149
9739170-5	1998	However, genistein did not alter the amylase release stimulated by TPA but inhibited TPA-stimulated p125FAK and paxillin tyrosine phosphorylation by 70%.	Tetradecanoylphorbol Acetate	85-88	paxillin	Rattus norvegicus	112-120
9724043-5	1998	Raf-1 and B-Raf, but not A-Raf, were activated by PGF2alpha (1 microM) and the pharmacological PKC activator phorbol myristate acetate (PMA, 20 nM).	Tetradecanoylphorbol Acetate	109-134	RAF1	Bos taurus	0-5
9724043-5	1998	Raf-1 and B-Raf, but not A-Raf, were activated by PGF2alpha (1 microM) and the pharmacological PKC activator phorbol myristate acetate (PMA, 20 nM).	Tetradecanoylphorbol Acetate	109-134	B-Raf proto-oncogene, serine/threonine kinase	Bos taurus	10-15
8864900-3	1996	Stimulation of [3H]thymidine incorporation (TDR) into DNA by bFGF was determined in the presence of phorbol myristate acetate of (PMA) to down-regulate the protein kinase C (PKC) pathway, genistein, an inhibitor of tyrosine kinase and H-7, a PKC inhibitor, bFGF 10(-8) M and PMA 10(-7) M increased TDR by 242 and 245%, respectively.	Tetradecanoylphorbol Acetate	100-125	fibroblast growth factor 2	Rattus norvegicus	61-65
11268405-5	2000	Moreover, PMA + ionomycin, which mimic the proliferative signal of anti-CD3, inhibited the expression of DOR mRNA.	Tetradecanoylphorbol Acetate	10-13	CD3 antigen, epsilon polypeptide	Mus musculus	72-75
8864900-3	1996	Stimulation of [3H]thymidine incorporation (TDR) into DNA by bFGF was determined in the presence of phorbol myristate acetate of (PMA) to down-regulate the protein kinase C (PKC) pathway, genistein, an inhibitor of tyrosine kinase and H-7, a PKC inhibitor, bFGF 10(-8) M and PMA 10(-7) M increased TDR by 242 and 245%, respectively.	Tetradecanoylphorbol Acetate	130-133	fibroblast growth factor 2	Rattus norvegicus	61-65
8864900-8	1996	A 24 h pretreatment with PMA at 10(-7) M inhibited the mitogenic response, tyrosine phosphorylation of MAPK, and induction of c-fos mRNA subsequent to the addition of PMA, but not bFGF.	Tetradecanoylphorbol Acetate	25-28	fibroblast growth factor 2	Rattus norvegicus	180-184
8702932-7	1996	C/EBPalpha activation was synergistic with phorbol 12-myristate 13-acetate and forskolin, activators of protein kinases C and A, respectively.	Tetradecanoylphorbol Acetate	43-74	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	0-10
9724043-5	1998	Raf-1 and B-Raf, but not A-Raf, were activated by PGF2alpha (1 microM) and the pharmacological PKC activator phorbol myristate acetate (PMA, 20 nM).	Tetradecanoylphorbol Acetate	136-139	RAF1	Bos taurus	0-5
9724043-5	1998	Raf-1 and B-Raf, but not A-Raf, were activated by PGF2alpha (1 microM) and the pharmacological PKC activator phorbol myristate acetate (PMA, 20 nM).	Tetradecanoylphorbol Acetate	136-139	B-Raf proto-oncogene, serine/threonine kinase	Bos taurus	10-15
9724043-9	1998	Additionally, both PGF2alpha (1 microM) and PMA (20 nM) stimulated phosphorylation of Raf-1, MEK1, and p42mapk in 32P-labeled cells.	Tetradecanoylphorbol Acetate	44-47	RAF1	Bos taurus	86-91
9724043-9	1998	Additionally, both PGF2alpha (1 microM) and PMA (20 nM) stimulated phosphorylation of Raf-1, MEK1, and p42mapk in 32P-labeled cells.	Tetradecanoylphorbol Acetate	44-47	erythrocyte membrane protein band 4.2	Bos taurus	103-106
9706865-5	1998	Treatment with TPA, which suppressed ERalpha mRNA levels, caused a greater than fourfold elevation of AhR mRNA and protein levels, whereas treatment with TCDD caused a decrease in AhR protein but no change in ERalpha or AhR mRNA levels.	Tetradecanoylphorbol Acetate	15-18	aryl hydrocarbon receptor	Homo sapiens	102-105
9706865-6	1998	In MCF-7 cells treated with TPA prior to treatment with TCDD, the AhR mRNA level was elevated, the ERalpha mRNA level remained suppressed, and the ratio of CYP1B1 to CYP1A1 mRNA was increased compared with treatment with TCDD alone.	Tetradecanoylphorbol Acetate	28-31	aryl hydrocarbon receptor	Homo sapiens	66-69
9706865-6	1998	In MCF-7 cells treated with TPA prior to treatment with TCDD, the AhR mRNA level was elevated, the ERalpha mRNA level remained suppressed, and the ratio of CYP1B1 to CYP1A1 mRNA was increased compared with treatment with TCDD alone.	Tetradecanoylphorbol Acetate	28-31	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	156-162
8702551-8	1996	The effect of Mn-SOD overexpression on IL-1alpha expression can be overcome by treatment with the protein kinase C activator, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	126-157	superoxide dismutase 2	Homo sapiens	14-20
10630309-4	2000	Phorbol 12-myristate 13-acetate and all-trans-retinoic acid, which induce differentiation in U-937 cells, up-regulated CD11b (MAC1 alpha-integrin) and CD82 and down-regulated CD71 (transferrin receptor) in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	0-31	transferrin receptor	Homo sapiens	175-179
8770045-7	1996	Finally, cholesterol 7 alpha-hydroxylase mRNA was repressed &gt; 75% by phorbol 12-myristate 13-acetate (100 nM for 3 h), a nonselective activator of PKC isoforms.	Tetradecanoylphorbol Acetate	72-103	protein kinase C, delta	Rattus norvegicus	150-153
10630309-4	2000	Phorbol 12-myristate 13-acetate and all-trans-retinoic acid, which induce differentiation in U-937 cells, up-regulated CD11b (MAC1 alpha-integrin) and CD82 and down-regulated CD71 (transferrin receptor) in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	0-31	transferrin receptor	Homo sapiens	181-201
8757771-8	1996	Moreover, for two of these isozymes (betaII and eta), the localization differs after phorbol 12-myristate 13-acetate treatment as compared with collagen treatment.	Tetradecanoylphorbol Acetate	85-116	endothelin receptor type A	Homo sapiens	38-41
10890505-0	2000	Hydroquinone inhibits PMA-induced activation of NFkappaB in primary human CD19+ B lymphocytes.	Tetradecanoylphorbol Acetate	22-25	CD19 molecule	Homo sapiens	74-78
8906122-1	1996	It has already been clarified that peripheral blood T-lymphocytes which had been activated with phorbol 12-myristate 13-acetate (PMA) acquired the ability to bind to human gingival fibroblasts (HGF) and that the adherence was mediated by VLA integrins.	Tetradecanoylphorbol Acetate	96-127	hepatocyte growth factor	Homo sapiens	194-197
8906122-1	1996	It has already been clarified that peripheral blood T-lymphocytes which had been activated with phorbol 12-myristate 13-acetate (PMA) acquired the ability to bind to human gingival fibroblasts (HGF) and that the adherence was mediated by VLA integrins.	Tetradecanoylphorbol Acetate	129-132	hepatocyte growth factor	Homo sapiens	194-197
9766436-6	1998	PGHS-2-catalyzed prostaglandin synthesis stimulated by the phorbol ester 12-O-tetradecanoylphorbol-13 acetate (TPA) in mouse epidermis in vivo was dose-dependently suppressed by topical administration of SC-58125, a specific PGHS-2 inhibitor.	Tetradecanoylphorbol Acetate	111-114	prostaglandin-endoperoxide synthase 2	Mus musculus	0-6
9766436-6	1998	PGHS-2-catalyzed prostaglandin synthesis stimulated by the phorbol ester 12-O-tetradecanoylphorbol-13 acetate (TPA) in mouse epidermis in vivo was dose-dependently suppressed by topical administration of SC-58125, a specific PGHS-2 inhibitor.	Tetradecanoylphorbol Acetate	111-114	prostaglandin-endoperoxide synthase 2	Mus musculus	225-231
9714250-3	1998	A 23 bp region in the promoter, from nucleotide -38 to -16, was identified as necessary for regulating the expression of BcLF1, i.e. the promoter activity is activated by 12-O-tetradecanoylphorbol 13-acetate but is repressed by phosphonoacetic acid.	Tetradecanoylphorbol Acetate	171-207	translin	Homo sapiens	121-126
8707424-8	1996	Using TPA, the expression of ERV3 env was detected as 9- and 3.5-kb transcripts by Northern blotting, as mRNA by in situ hybridization and as a cytoplasmic 65-kDa protein by immunofluorescence and Western blots.	Tetradecanoylphorbol Acetate	6-9	endogenous retrovirus group 3 member 1, envelope	Homo sapiens	29-33
10890505-6	2000	In this study, we demonstrate that 1-10 micromol/L HQ inhibits PMA/ionomycin-induced activation of NFkappaB in primary human CD19+ B cells.	Tetradecanoylphorbol Acetate	63-66	CD19 molecule	Homo sapiens	125-129
11448065-6	2000	Finally, PMA-induced MMP-9 expression and capillary formation were inhibited by the MEKK-specific inhibitor PD98059.	Tetradecanoylphorbol Acetate	9-12	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	84-88
8663100-7	1996	The MAPK and NHE activities induced by PMA were inhibited by staurosporine, a potent inhibitor for protein kinase C (PKC), and by MAPK kinase (MEK) inhibitor, PD98059, but were not affected by the tyrosine kinase inhibitor genistein.	Tetradecanoylphorbol Acetate	39-42	solute carrier family 9 member C1	Homo sapiens	13-16
8663147-5	1996	This work also shows that activated TAFI down-regulates tPA-induced fibrinolysis half-maximally at a concentration of 1.0 nM in a system of purified components.	Tetradecanoylphorbol Acetate	56-59	carboxypeptidase B2	Homo sapiens	36-40
9717725-1	1998	Stimulation with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore ionomycin increased native low density lipoprotein (LDL) receptor gene expression in the human leukemic T cell line Jurkat when cells were cultured in the absence of sterols and also increased nuclear accumulation of sterol regulatory element binding protein (SREBP)-1.	Tetradecanoylphorbol Acetate	17-48	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	298-339
9717725-1	1998	Stimulation with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore ionomycin increased native low density lipoprotein (LDL) receptor gene expression in the human leukemic T cell line Jurkat when cells were cultured in the absence of sterols and also increased nuclear accumulation of sterol regulatory element binding protein (SREBP)-1.	Tetradecanoylphorbol Acetate	17-48	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	341-346
8760139-3	1996	Treatment of type II cells with 80 nM phorbol 12-myristate 13-acetate (PMA) increased the resting pHi in a time-dependent manner.	Tetradecanoylphorbol Acetate	38-69	glucose-6-phosphate isomerase	Homo sapiens	98-101
9717725-1	1998	Stimulation with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore ionomycin increased native low density lipoprotein (LDL) receptor gene expression in the human leukemic T cell line Jurkat when cells were cultured in the absence of sterols and also increased nuclear accumulation of sterol regulatory element binding protein (SREBP)-1.	Tetradecanoylphorbol Acetate	50-53	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	298-339
8760139-3	1996	Treatment of type II cells with 80 nM phorbol 12-myristate 13-acetate (PMA) increased the resting pHi in a time-dependent manner.	Tetradecanoylphorbol Acetate	71-74	glucose-6-phosphate isomerase	Homo sapiens	98-101
10601319-0	1999	Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate.	Tetradecanoylphorbol Acetate	88-116	superoxide dismutase 2	Homo sapiens	40-70
8694751-13	1996	Exposure of cells to phorbol 12-myristate 13-acetate for 24 h inhibited subsequent activation of p42/p44-MAPK by BK suggesting participation of nPKC (and possibly cPKC) isoforms in the activation process.	Tetradecanoylphorbol Acetate	21-52	mitogen activated protein kinase 3	Rattus norvegicus	101-104
8694751-13	1996	Exposure of cells to phorbol 12-myristate 13-acetate for 24 h inhibited subsequent activation of p42/p44-MAPK by BK suggesting participation of nPKC (and possibly cPKC) isoforms in the activation process.	Tetradecanoylphorbol Acetate	21-52	mitogen activated protein kinase 3	Rattus norvegicus	105-109
9717725-1	1998	Stimulation with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore ionomycin increased native low density lipoprotein (LDL) receptor gene expression in the human leukemic T cell line Jurkat when cells were cultured in the absence of sterols and also increased nuclear accumulation of sterol regulatory element binding protein (SREBP)-1.	Tetradecanoylphorbol Acetate	50-53	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	341-346
10601319-1	1999	Transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA induced by a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was examined to identify the responsive transcriptional regulator.	Tetradecanoylphorbol Acetate	108-144	superoxide dismutase 2	Homo sapiens	36-66
9841266-5	1998	Phorbol myristate acetate, PMA, which activates protein kinase C, PKC, activates p38 MAP kinase.	Tetradecanoylphorbol Acetate	0-25	mitogen activated protein kinase 14	Rattus norvegicus	81-84
9841266-5	1998	Phorbol myristate acetate, PMA, which activates protein kinase C, PKC, activates p38 MAP kinase.	Tetradecanoylphorbol Acetate	27-30	mitogen activated protein kinase 14	Rattus norvegicus	81-84
8663012-6	1996	Since B-Raf contains a cysteine-rich domain originally found in protein kinase C as a domain responsible for interaction with phosphatidylserine (PS) and diacylglycerol or 12-O-tetradecanoylphorbol-13-acetate, we have examined here the effect of these compounds on the Ki-Ras-, Ha-Ras-, and Rap1B-induced activation of bovine brain B-Raf.	Tetradecanoylphorbol Acetate	172-208	B-Raf proto-oncogene, serine/threonine kinase	Bos taurus	6-11
10585882-9	1999	PMA had no effect on the activity of sphingomyelinase in either untreated or alpha-depleted cytosol but significantly increased the activity of sphingomyelinase when added to cytosol depleted of PKC delta.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	195-204
8662934-1	1996	Transcriptional regulation of the human histidine decarboxylase (HDC) gene by gastrin and the phorbol ester phorbol 12-myristate 13-acetate (PMA) was studied using transient transfection of human HDC promoter-luciferase constructs in a human gastric carcinoma cell line (AGS-B) that expresses the human cholecystokinin-B/gastrin receptor.	Tetradecanoylphorbol Acetate	141-144	histidine decarboxylase	Homo sapiens	40-63
8662934-1	1996	Transcriptional regulation of the human histidine decarboxylase (HDC) gene by gastrin and the phorbol ester phorbol 12-myristate 13-acetate (PMA) was studied using transient transfection of human HDC promoter-luciferase constructs in a human gastric carcinoma cell line (AGS-B) that expresses the human cholecystokinin-B/gastrin receptor.	Tetradecanoylphorbol Acetate	141-144	histidine decarboxylase	Homo sapiens	65-68
8654580-3	1996	The Fos and Jun components of AP1 were induced rapidly and transiently in PC12 cells following the addition of phorbol ester (phorbol 12-myristate 13-acetate, PMA).	Tetradecanoylphorbol Acetate	126-157	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-33
8654580-3	1996	The Fos and Jun components of AP1 were induced rapidly and transiently in PC12 cells following the addition of phorbol ester (phorbol 12-myristate 13-acetate, PMA).	Tetradecanoylphorbol Acetate	159-162	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-33
9680096-2	1998	Progressive decreases in the steady-state levels of the mRNAs for thymidylate synthase, topoisomerase II, and hypoxanthine guanine phosphoribosyltransferase occurred following exposure to TPA or vitamin D3.	Tetradecanoylphorbol Acetate	188-191	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	110-156
10585882-10	1999	Moreover, PMA inhibited the effect of 1,25(OH)(2)D(3) on sphingomyelinase activation but the inhibitory effect was abolished by prior depletion of PKC delta from the cytosol.	Tetradecanoylphorbol Acetate	10-13	protein kinase C delta	Homo sapiens	147-156
8662792-3	1996	Phorbol 12-myristate 13-acetate (PMA) treatment induced the in vitro phosphorylation of CD28 on threonine as detected in immune complex kinase assays.	Tetradecanoylphorbol Acetate	0-31	CD28 molecule	Homo sapiens	88-92
9688899-7	1998	Furthermore, stimulation of endothelial cells with histamine or phorbol myristate acetate (PMA) enhanced tyrosine phosphorylation of paxillin and pp125FAK, which was blocked by the tyrosine kinase inhibitor damnacanthal.	Tetradecanoylphorbol Acetate	64-89	protein tyrosine kinase 2	Homo sapiens	146-154
10600794-9	1999	ET-1 or TPA induced the phosphorylation of p38 MAP kinase.	Tetradecanoylphorbol Acetate	8-11	mitogen-activated protein kinase 14	Mus musculus	43-46
9688899-7	1998	Furthermore, stimulation of endothelial cells with histamine or phorbol myristate acetate (PMA) enhanced tyrosine phosphorylation of paxillin and pp125FAK, which was blocked by the tyrosine kinase inhibitor damnacanthal.	Tetradecanoylphorbol Acetate	91-94	protein tyrosine kinase 2	Homo sapiens	146-154
8662792-3	1996	Phorbol 12-myristate 13-acetate (PMA) treatment induced the in vitro phosphorylation of CD28 on threonine as detected in immune complex kinase assays.	Tetradecanoylphorbol Acetate	33-36	CD28 molecule	Homo sapiens	88-92
8805854-5	1996	Phorbol myristate acetate (PMA) induced macrophage-like differentiation and up-regulated the gamma c chain mRNA expression in THP-1 cells.	Tetradecanoylphorbol Acetate	27-30	interleukin 2 receptor subunit gamma	Homo sapiens	93-100
10602019-8	1999	These results suggest that the T cell stimulation via anti-CD3 cross-linking or phorbol myristate acetate treatment up-regulates CD82 expression, leading to the colocalization of CD82 and LFA-1, and results in enhanced interaction between LFA-1 and ICAM-1.	Tetradecanoylphorbol Acetate	80-105	integrin subunit alpha L	Homo sapiens	188-193
8703801-4	1996	When differentiation of MEG-01 was induced by 100 nm 12-O-tetradecanoyl-phorbol-13-acetate (TPA), rapid translocation from cytosol to membrane fraction and down-regulation of PKC alpha, -epsilon and -theta was observed in 1-2h.	Tetradecanoylphorbol Acetate	53-90	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	24-27
8703801-4	1996	When differentiation of MEG-01 was induced by 100 nm 12-O-tetradecanoyl-phorbol-13-acetate (TPA), rapid translocation from cytosol to membrane fraction and down-regulation of PKC alpha, -epsilon and -theta was observed in 1-2h.	Tetradecanoylphorbol Acetate	92-95	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	24-27
9703914-5	1998	In fact, in the high metastatic BL6 cells the long-term treatment for 24 hours with TPA, with no c-PKC activation or the inhibition with Go6976 as well as with BIM, induced an increased NF-kB and AP1 DNA-binding activity.	Tetradecanoylphorbol Acetate	84-87	jun proto-oncogene	Mus musculus	196-199
9703914-6	1998	In contrast, in the low metastatic B16F1 cells the short-term treatment with TPA, induced the activation of c-PKCs isoforms, and enhanced NF-kB and AP1 DNA-binding activity.	Tetradecanoylphorbol Acetate	77-80	jun proto-oncogene	Mus musculus	148-151
9658190-4	1998	Chemical inhibition of either MAPK or MAPK kinase blocked the response of a transfected chromogranin A promoter to nicotine or protein kinase C activation [by phorbol-12-myristate-13-acetate (PMA)], although nicotine-evoked catecholamine secretion was unaffected.	Tetradecanoylphorbol Acetate	159-190	chromogranin A	Rattus norvegicus	88-102
9658190-4	1998	Chemical inhibition of either MAPK or MAPK kinase blocked the response of a transfected chromogranin A promoter to nicotine or protein kinase C activation [by phorbol-12-myristate-13-acetate (PMA)], although nicotine-evoked catecholamine secretion was unaffected.	Tetradecanoylphorbol Acetate	192-195	chromogranin A	Rattus norvegicus	88-102
9658190-6	1998	Cotransfection of MAPK pathway dominant negative mutants (for Raf, MAPK, or CREB kinase) blocked nicotinic or PMA activation of chromogranin A, although a dominant negative Ras mutant was without effect.	Tetradecanoylphorbol Acetate	110-113	chromogranin A	Rattus norvegicus	128-142
8762106-11	1996	Short pretreatment of the cells with the phorbol ester, 4-beta-phorbol-12-beta-myristate-13-alpha-acetate (PMA), an activator of PKC, reduced the GLP-1(7-36)amide-evoked increase in [Ca2+]i by 75%.	Tetradecanoylphorbol Acetate	107-110	glucagon	Mus musculus	146-151
10602019-8	1999	These results suggest that the T cell stimulation via anti-CD3 cross-linking or phorbol myristate acetate treatment up-regulates CD82 expression, leading to the colocalization of CD82 and LFA-1, and results in enhanced interaction between LFA-1 and ICAM-1.	Tetradecanoylphorbol Acetate	80-105	integrin subunit alpha L	Homo sapiens	239-244
8780891-8	1996	A high concentration of TPA (1.6 microM) down regulated PKC-alpha and PKC-beta I almost completely and PKC-epsilon partially in wild-type SH-SY5Y and SH-SY5Y/trk cells.	Tetradecanoylphorbol Acetate	24-27	neurotrophic receptor tyrosine kinase 1	Homo sapiens	158-161
8780895-11	1996	Reverse transcription-PCR and Western blot analyses revealed that untreated THP-1 cells contain HGF transcript and protein, and that HGF expression is inducible by addition of the differentiation agents such as 12-O-tetradecanoylphorbol-13 acetate or IL-6 plus TNF-alpha.	Tetradecanoylphorbol Acetate	211-247	hepatocyte growth factor	Homo sapiens	133-136
9099936-10	1996	Both spontaneous and up-regulated expression of ICAM-1, LFA-3 and VCAM-1 by IFN-gamma, IL-1beta or 12-o-tetradecanoyl phorbol 13-acetate (TPA) were markedly suppressed by clarithromycin in a dose-dependent manner at concentrations between 0.1 and 10 microg/ml.	Tetradecanoylphorbol Acetate	99-136	CD58 molecule	Homo sapiens	56-61
9099936-10	1996	Both spontaneous and up-regulated expression of ICAM-1, LFA-3 and VCAM-1 by IFN-gamma, IL-1beta or 12-o-tetradecanoyl phorbol 13-acetate (TPA) were markedly suppressed by clarithromycin in a dose-dependent manner at concentrations between 0.1 and 10 microg/ml.	Tetradecanoylphorbol Acetate	138-141	CD58 molecule	Homo sapiens	56-61
9658190-8	1998	Point mutations of the chromogranin A CRE suggested that this element was necessary in cis for stimulation by nicotine, PMA, or chemical activation of the MAPK pathway.	Tetradecanoylphorbol Acetate	120-123	chromogranin A	Rattus norvegicus	23-37
10619397-6	1999	Treatment by forskolin or 12-O-tetradecanoylphorbol-13-acetate (TPA) caused a 1.5- and 10-fold increase, respectively, in SgII mRNA levels in SH-SY5Y cells but not in AtT-20 cells.	Tetradecanoylphorbol Acetate	26-62	secretogranin II	Homo sapiens	122-126
8682655-2	1996	Macrophage activation was achieved by cell incubation with phorbol myristate acetate (PMA) for 24 h at 37 degrees C, and was determined as: a) PMA concentration-dependent increment in the release of beta-glucuronidase, b) decrement in the procoagulant activity, and c) increment in the release of superoxides from the cells.	Tetradecanoylphorbol Acetate	59-84	glucuronidase beta	Homo sapiens	199-217
10619397-6	1999	Treatment by forskolin or 12-O-tetradecanoylphorbol-13-acetate (TPA) caused a 1.5- and 10-fold increase, respectively, in SgII mRNA levels in SH-SY5Y cells but not in AtT-20 cells.	Tetradecanoylphorbol Acetate	64-67	secretogranin II	Homo sapiens	122-126
8682655-2	1996	Macrophage activation was achieved by cell incubation with phorbol myristate acetate (PMA) for 24 h at 37 degrees C, and was determined as: a) PMA concentration-dependent increment in the release of beta-glucuronidase, b) decrement in the procoagulant activity, and c) increment in the release of superoxides from the cells.	Tetradecanoylphorbol Acetate	86-89	glucuronidase beta	Homo sapiens	199-217
8682655-2	1996	Macrophage activation was achieved by cell incubation with phorbol myristate acetate (PMA) for 24 h at 37 degrees C, and was determined as: a) PMA concentration-dependent increment in the release of beta-glucuronidase, b) decrement in the procoagulant activity, and c) increment in the release of superoxides from the cells.	Tetradecanoylphorbol Acetate	143-146	glucuronidase beta	Homo sapiens	199-217
10619397-11	1999	Forskolin and TPA stimulated the activity of a SgII-luciferase fusion gene in SH-SY5Y but not in AtT-20 cells.	Tetradecanoylphorbol Acetate	14-17	secretogranin II	Homo sapiens	47-51
8632179-7	1996	Relative to IL-1 beta, the greater increases in PGE2 production and cyclooxygenase activity caused by TPA correlated with a greater induction of PGHS-2 mRNA.	Tetradecanoylphorbol Acetate	102-105	prostaglandin-endoperoxide synthase 2	Mus musculus	145-151
9647744-2	1998	The data show that the classical PKC isoenzymes, alpha and beta, were activated by TPA and at a time prior to NADPH oxidase complex assembly.	Tetradecanoylphorbol Acetate	83-86	protein kinase C beta	Homo sapiens	33-36
10597271-2	1999	We found that TPA treatment of HC11 cells induced a transient cell cycle arrest in G0/G1.	Tetradecanoylphorbol Acetate	14-17	heterochromatin, Chr 11	Mus musculus	31-35
9601066-0	1998	Overlapping antioxidant response element and PMA response element sequences mediate basal and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase catalytic subunit gene.	Tetradecanoylphorbol Acetate	45-48	glutamate-cysteine ligase catalytic subunit	Homo sapiens	146-179
8632179-8	1996	Furthermore NS-398, a specific inhibitor of cyclooxygenase-2, blocked &gt; 80% of the cyclooxygenase activity in TPA-treated astrocytes.	Tetradecanoylphorbol Acetate	113-116	prostaglandin-endoperoxide synthase 2	Mus musculus	44-60
10597271-4	1999	Indeed, derivatives of the HC11 cell line that inducibly overexpress an exogenous PKC alpha or ectopic PKC beta 1 exhibited more marked growth inhibition by TPA than control cells.	Tetradecanoylphorbol Acetate	157-160	heterochromatin, Chr 11	Mus musculus	27-31
8648429-6	1996	Lipopolysaccharide- and PMA-activated macrophages from mice fed the trimyristin diet had significantly greater levels of MacMARCKS than LPS- and PMA-activated macrophages of mice fed the safflower oil-containing diet.	Tetradecanoylphorbol Acetate	24-27	MARCKS-like 1	Mus musculus	121-130
10597271-6	1999	The transient arrest of HC11 cells following treatment with TPA was associated with marked induction of both p21cip1 mRNA and protein.	Tetradecanoylphorbol Acetate	60-63	heterochromatin, Chr 11	Mus musculus	24-28
8648726-3	1996	Previous work identified four related elements (ZIA, ZIB, ZIC, and ZID) and a cyclic AMP response element binding-AP-1 element (ZII) that are involved in the induction of the BZLF1 promoter (Zp) by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (E. Flemington and S. H. Speck, J. Virol.	Tetradecanoylphorbol Acetate	216-252	Zic family member 1	Homo sapiens	58-61
8648726-3	1996	Previous work identified four related elements (ZIA, ZIB, ZIC, and ZID) and a cyclic AMP response element binding-AP-1 element (ZII) that are involved in the induction of the BZLF1 promoter (Zp) by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (E. Flemington and S. H. Speck, J. Virol.	Tetradecanoylphorbol Acetate	254-257	Zic family member 1	Homo sapiens	58-61
9602173-3	1998	We report here that the human junD promoter is repressed by serum and TPA.	Tetradecanoylphorbol Acetate	70-73	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-34
9602173-6	1998	We found that c-Fos, a bZip protein known to be induced by serum and TPA, is sufficient to antagonize the JunD function.	Tetradecanoylphorbol Acetate	69-72	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-110
10551823-5	1999	Stimulation of neutrophil-like HL-60 cells with phorbol 12-myristate 13-acetate led to the secretion of S100A8/A9 protein complex, which carried the released arachidonic acid.	Tetradecanoylphorbol Acetate	48-79	S100 calcium binding protein A8	Homo sapiens	104-110
9615391-8	1998	In addition, bryostatin 1 was less effective than PMA in dephosphorylating pRb, modifying E2F complexes, and downregulating c-Myc.	Tetradecanoylphorbol Acetate	50-53	RB transcriptional corepressor 1	Homo sapiens	75-78
9615391-9	1998	Co-administration of bryostatin 1 with PMA antagonized the latter"s differentiation-inducing capacity and anti-proliferative effects, actions that were accompanied by a reduction in PMA-mediated p21CIP1/WAF1 induction, CDK2 inhibition, pRb dephosphorylation, and c-Myc downregulation.	Tetradecanoylphorbol Acetate	39-42	cyclin dependent kinase 2	Homo sapiens	219-223
9615391-9	1998	Co-administration of bryostatin 1 with PMA antagonized the latter"s differentiation-inducing capacity and anti-proliferative effects, actions that were accompanied by a reduction in PMA-mediated p21CIP1/WAF1 induction, CDK2 inhibition, pRb dephosphorylation, and c-Myc downregulation.	Tetradecanoylphorbol Acetate	39-42	RB transcriptional corepressor 1	Homo sapiens	236-239
9603471-4	1998	In contrast, the phorbol 12-myristate 13-acetate (PMA)-induced IL-10 production and CD69 expression, and the ionomycin plus PMA-induced IL-2 production are not affected.	Tetradecanoylphorbol Acetate	17-48	CD69 molecule	Homo sapiens	84-88
9603471-4	1998	In contrast, the phorbol 12-myristate 13-acetate (PMA)-induced IL-10 production and CD69 expression, and the ionomycin plus PMA-induced IL-2 production are not affected.	Tetradecanoylphorbol Acetate	50-53	CD69 molecule	Homo sapiens	84-88
8648726-7	1996	Cloning of individual ZI domains upstream of a minimal promoter demonstrated that the ZIA, ZIC, and ZID domains, but not the ZIB domain, are TPA responsive.	Tetradecanoylphorbol Acetate	141-144	Zic family member 1	Homo sapiens	91-94
8648726-12	1996	Functional analyses of the ZIC domain revealed that the 5" region of this domain is largely responsible for mediating TPA induction.	Tetradecanoylphorbol Acetate	118-121	Zic family member 1	Homo sapiens	27-30
8648726-15	1996	These data provide a direct demonstration of TPA induction mediated by the ZIA, ZIC, and ZID domains and also provide the first evidence that the ZI domains exhibit distinct functional characteristics.	Tetradecanoylphorbol Acetate	45-48	Zic family member 1	Homo sapiens	80-83
8621897-4	1996	When up-regulation of Fas lytic function was induced by PMA and ionomycin, EGTA blocked both activation of lytic function and expression of Fas ligand detected by FACS analysis.	Tetradecanoylphorbol Acetate	56-59	acyl-CoA synthetase long-chain family member 1	Mus musculus	163-167
10542228-4	1999	This study delineates the functional significance of DOC-2/DAB2 protein phosphorylation and demonstrates that in vivo activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) induces DOC-2/DAB2 phosphorylation, including a serine residue at position 24.	Tetradecanoylphorbol Acetate	158-194	DAB adaptor protein 2	Homo sapiens	59-63
8626698-9	1996	A causal link between PKC beta overexpression and ERK3 activation was established because 12-O-tetradecanoylphorbol-13-acetate treatment down-regulated both PKC and ERK3 activities in both PKC beta 1 transfectants.	Tetradecanoylphorbol Acetate	90-126	protein kinase C, beta	Mus musculus	22-30
8626698-9	1996	A causal link between PKC beta overexpression and ERK3 activation was established because 12-O-tetradecanoylphorbol-13-acetate treatment down-regulated both PKC and ERK3 activities in both PKC beta 1 transfectants.	Tetradecanoylphorbol Acetate	90-126	mitogen-activated protein kinase 6	Mus musculus	50-54
8626698-9	1996	A causal link between PKC beta overexpression and ERK3 activation was established because 12-O-tetradecanoylphorbol-13-acetate treatment down-regulated both PKC and ERK3 activities in both PKC beta 1 transfectants.	Tetradecanoylphorbol Acetate	90-126	mitogen-activated protein kinase 6	Mus musculus	165-169
8626698-9	1996	A causal link between PKC beta overexpression and ERK3 activation was established because 12-O-tetradecanoylphorbol-13-acetate treatment down-regulated both PKC and ERK3 activities in both PKC beta 1 transfectants.	Tetradecanoylphorbol Acetate	90-126	protein kinase C, beta	Mus musculus	189-197
8963726-10	1996	The phorbol ester TPA induced a rearrangement of PKC delta and a translocation of PKC alpha and epsilon to the nucleus.	Tetradecanoylphorbol Acetate	18-21	protein kinase C delta	Homo sapiens	49-58
9572272-3	1998	TPA treatment in the presence of serum induced NPY transcription in both wild-type SH-SY5Y (SH-SY5Y/wt) and SH-SY5Y/trk cells.	Tetradecanoylphorbol Acetate	0-3	neurotrophic receptor tyrosine kinase 1	Homo sapiens	116-119
10542228-4	1999	This study delineates the functional significance of DOC-2/DAB2 protein phosphorylation and demonstrates that in vivo activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) induces DOC-2/DAB2 phosphorylation, including a serine residue at position 24.	Tetradecanoylphorbol Acetate	158-194	protein kinase C delta	Homo sapiens	150-153
9572272-5	1998	Suppression of TPA-induced NPY transcription was obtained by expression of a dominant negative Jun protein, selective protein kinase C inhibition, or introduction of a mutated TRE, whereas NGF-induced NPY transcription was inhibited to a lesser degree.	Tetradecanoylphorbol Acetate	15-18	trehalase	Homo sapiens	176-179
8613475-4	1996	TPA treatment of HT1080 cells induced the expression of interstitial collagenase (MMP-1) and increased the expression of gelatinase B (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), and MT-MMP, a membrane-bound activator of progelatinase A (proMMP-2), while MMP-2 and TIMP-2 expression were decreased.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 14	Homo sapiens	198-204
8613475-4	1996	TPA treatment of HT1080 cells induced the expression of interstitial collagenase (MMP-1) and increased the expression of gelatinase B (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), and MT-MMP, a membrane-bound activator of progelatinase A (proMMP-2), while MMP-2 and TIMP-2 expression were decreased.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 2	Homo sapiens	236-251
10542228-4	1999	This study delineates the functional significance of DOC-2/DAB2 protein phosphorylation and demonstrates that in vivo activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) induces DOC-2/DAB2 phosphorylation, including a serine residue at position 24.	Tetradecanoylphorbol Acetate	158-194	DAB adaptor protein 2	Homo sapiens	209-214
8613475-4	1996	TPA treatment of HT1080 cells induced the expression of interstitial collagenase (MMP-1) and increased the expression of gelatinase B (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), and MT-MMP, a membrane-bound activator of progelatinase A (proMMP-2), while MMP-2 and TIMP-2 expression were decreased.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 2	Homo sapiens	256-261
8613475-5	1996	Increased MT-MMP expression by TPA treatment was associated with increased activation of proMMP-2.	Tetradecanoylphorbol Acetate	31-34	matrix metallopeptidase 14	Homo sapiens	10-16
10542228-4	1999	This study delineates the functional significance of DOC-2/DAB2 protein phosphorylation and demonstrates that in vivo activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) induces DOC-2/DAB2 phosphorylation, including a serine residue at position 24.	Tetradecanoylphorbol Acetate	158-194	DAB adaptor protein 2	Homo sapiens	215-219
9563629-8	1998	Treatment with all 3 PKC inhibitors caused marked reduction in TF expression of cells stimulated with LPS alone or with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	120-145	LOC101909187	Bos taurus	63-65
10542228-4	1999	This study delineates the functional significance of DOC-2/DAB2 protein phosphorylation and demonstrates that in vivo activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) induces DOC-2/DAB2 phosphorylation, including a serine residue at position 24.	Tetradecanoylphorbol Acetate	196-199	protein kinase C delta	Homo sapiens	150-153
8622882-7	1996	Gel shift assays demonstrated the mobility pattern of TPA-responsive element (TRE) binding complex with AP-1 derived from H-ras transfectants migrated faster than those from Balb-Neo1, v-myc and H-ras/v-myc.	Tetradecanoylphorbol Acetate	54-57	jun proto-oncogene	Mus musculus	104-108
10542228-4	1999	This study delineates the functional significance of DOC-2/DAB2 protein phosphorylation and demonstrates that in vivo activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) induces DOC-2/DAB2 phosphorylation, including a serine residue at position 24.	Tetradecanoylphorbol Acetate	196-199	DAB adaptor protein 2	Homo sapiens	209-214
10542228-4	1999	This study delineates the functional significance of DOC-2/DAB2 protein phosphorylation and demonstrates that in vivo activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) induces DOC-2/DAB2 phosphorylation, including a serine residue at position 24.	Tetradecanoylphorbol Acetate	196-199	DAB adaptor protein 2	Homo sapiens	215-219
9546316-5	1998	HDC activity was increased from 52.1+/-0.4 (mean+/-standard deviation) to 154+/-6.9, or 105.6+/-6.2 pmol/min/mg protein (n = 3), 4 hours after stimulation with PMA (10 ng/mL) or ionomycin (10[-6] M).	Tetradecanoylphorbol Acetate	160-163	histidine decarboxylase	Homo sapiens	0-3
8797807-2	1996	Preincubation of the wild type-STaR (wt-STaR) transfectant with 1 microM PMA caused additional STa-mediated guanylyl cyclase (GC) activation compared to control, whereas the mS1029A- and C delta 1029-transfected cells did not show a similar enhanced GC activation by PMA.	Tetradecanoylphorbol Acetate	73-76	guanylate cyclase 2C	Homo sapiens	31-35
10542228-8	1999	Since expression of wild-type DOC-2/DAB2, but not the S24A mutant, inhibited TPA-induced AP-1 activity in prostatic epithelial cells, phosphorylation of Ser(24) appears to play a critical role in modulating TPA-induced AP-1 activity.	Tetradecanoylphorbol Acetate	77-80	DAB adaptor protein 2	Homo sapiens	30-35
8797807-2	1996	Preincubation of the wild type-STaR (wt-STaR) transfectant with 1 microM PMA caused additional STa-mediated guanylyl cyclase (GC) activation compared to control, whereas the mS1029A- and C delta 1029-transfected cells did not show a similar enhanced GC activation by PMA.	Tetradecanoylphorbol Acetate	73-76	guanylate cyclase 2C	Homo sapiens	40-44
8928801-7	1996	In addition, the PMA-induced inhibition of CPT-I was not potentiated by thapsigargin, BHQ, or A-23187.	Tetradecanoylphorbol Acetate	17-20	carnitine palmitoyltransferase 1B	Rattus norvegicus	43-48
9546316-7	1998	The population of HMC-1 cells containing HDC protein was increased after stimulation with either PMA or ionomycin as evaluated by immunocytochemical analysis with anti-HDC antibody as a marker.	Tetradecanoylphorbol Acetate	97-100	histidine decarboxylase	Homo sapiens	41-44
9546316-7	1998	The population of HMC-1 cells containing HDC protein was increased after stimulation with either PMA or ionomycin as evaluated by immunocytochemical analysis with anti-HDC antibody as a marker.	Tetradecanoylphorbol Acetate	97-100	histidine decarboxylase	Homo sapiens	168-171
8635212-7	1996	Pretreatment with phorbol 12-myristate 13-acetate (PMA) to downregulate protein kinase C (PKC) attenuates thrombin- and TRAP-dependent activation of MAPK, although small and equivalent effects of thrombin and TRAP to stimulate MAPK persist in PMA-pretreated cells.	Tetradecanoylphorbol Acetate	18-49	tudor domain containing 7	Rattus norvegicus	120-124
10542228-8	1999	Since expression of wild-type DOC-2/DAB2, but not the S24A mutant, inhibited TPA-induced AP-1 activity in prostatic epithelial cells, phosphorylation of Ser(24) appears to play a critical role in modulating TPA-induced AP-1 activity.	Tetradecanoylphorbol Acetate	77-80	DAB adaptor protein 2	Homo sapiens	36-40
8635212-7	1996	Pretreatment with phorbol 12-myristate 13-acetate (PMA) to downregulate protein kinase C (PKC) attenuates thrombin- and TRAP-dependent activation of MAPK, although small and equivalent effects of thrombin and TRAP to stimulate MAPK persist in PMA-pretreated cells.	Tetradecanoylphorbol Acetate	18-49	tudor domain containing 7	Rattus norvegicus	209-213
10518804-3	1999	In these primary human cells, CsA significantly inhibited PMA/ionomycin-mediated and ionomycin-mediated activation of the MAPK kinase MKK6, as well as its downstream kinases SAPK2a (p38alpha) and MAPKAP-K2.	Tetradecanoylphorbol Acetate	58-61	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	30-33
8635212-7	1996	Pretreatment with phorbol 12-myristate 13-acetate (PMA) to downregulate protein kinase C (PKC) attenuates thrombin- and TRAP-dependent activation of MAPK, although small and equivalent effects of thrombin and TRAP to stimulate MAPK persist in PMA-pretreated cells.	Tetradecanoylphorbol Acetate	51-54	tudor domain containing 7	Rattus norvegicus	120-124
8635212-7	1996	Pretreatment with phorbol 12-myristate 13-acetate (PMA) to downregulate protein kinase C (PKC) attenuates thrombin- and TRAP-dependent activation of MAPK, although small and equivalent effects of thrombin and TRAP to stimulate MAPK persist in PMA-pretreated cells.	Tetradecanoylphorbol Acetate	51-54	tudor domain containing 7	Rattus norvegicus	209-213
8635230-7	1996	This is blocked by both phorbol 12-myristate 13-acetate (PMA) pretreatment to downregulate PKC and the PKC inhibitor chelerythrine, arguing that PKCepsilon plays a critical role in endothelin receptor-dependent increases in intracellular calcium.	Tetradecanoylphorbol Acetate	24-55	protein kinase C, epsilon	Mus musculus	145-155
8635230-7	1996	This is blocked by both phorbol 12-myristate 13-acetate (PMA) pretreatment to downregulate PKC and the PKC inhibitor chelerythrine, arguing that PKCepsilon plays a critical role in endothelin receptor-dependent increases in intracellular calcium.	Tetradecanoylphorbol Acetate	57-60	protein kinase C, epsilon	Mus musculus	145-155
9529167-8	1998	The tyrosine kinase inhibitor reduced the Ang II- and phorbol 12-myristate 13-acetate-induced KDR mRNA increases by 35+/-8% and 44+/-26%, respectively.	Tetradecanoylphorbol Acetate	54-85	kinase insert domain receptor	Bos taurus	94-97
9640246-6	1998	T-cell proliferation mediated through CD6/CD28 was only partially blocked by the immunosuppressive drug, cyclosporin A (CsA), whereas anti-CD28-induced T-cell proliferation in the presence of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was unaffected.	Tetradecanoylphorbol Acetate	211-247	CD28 molecule	Homo sapiens	139-143
9640246-6	1998	T-cell proliferation mediated through CD6/CD28 was only partially blocked by the immunosuppressive drug, cyclosporin A (CsA), whereas anti-CD28-induced T-cell proliferation in the presence of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was unaffected.	Tetradecanoylphorbol Acetate	249-252	CD28 molecule	Homo sapiens	139-143
10518804-4	1999	PMA/ionomycin treatment also mediated activation of SAPK1 (JNKs) which was inhibited by CsA.	Tetradecanoylphorbol Acetate	0-3	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	88-91
9651816-10	1998	Although the addition of 12-o-tetradecanoylphorbol-13-acetate (TPA) singly to the incubation medium had no effect on either Mn-, or Cu,Zn-SOD activity, it significantly augmented the IFN-gamma-dependent induction of Mn-SOD activity by anti-Fas antibody or by TNF-alpha.	Tetradecanoylphorbol Acetate	25-61	superoxide dismutase 2	Homo sapiens	216-222
8689410-14	1996	When cells were simultaneously treated with 1 mumol/L PMA and ionomycin together for 1 hour, the increase in HSP-70 and HSF1 mRNAs reached a greater level than the level stimulated by either drug alone.	Tetradecanoylphorbol Acetate	54-57	heat shock transcription factor 1	Homo sapiens	120-124
9651816-10	1998	Although the addition of 12-o-tetradecanoylphorbol-13-acetate (TPA) singly to the incubation medium had no effect on either Mn-, or Cu,Zn-SOD activity, it significantly augmented the IFN-gamma-dependent induction of Mn-SOD activity by anti-Fas antibody or by TNF-alpha.	Tetradecanoylphorbol Acetate	63-66	superoxide dismutase 2	Homo sapiens	216-222
10599999-1	1999	In the present study, exposure of human peripheral blood mononuclear cells (PBMC) to phorbol 12-myristate 13-acetate (PMA) was found to elicit the expression of CD14 on lymphocytes.	Tetradecanoylphorbol Acetate	85-116	CD14 molecule	Homo sapiens	161-165
9651816-11	1998	The protein kinase C inhibitor, 1-(5-isoquinoline-sulfonyl)-2-methyl piperazine dihydrochloride (H-7), significantly inhibited the TPA-dependent increase in Mn-SOD activity.	Tetradecanoylphorbol Acetate	131-134	superoxide dismutase 2	Homo sapiens	157-163
9480828-2	1998	In this study, the effects of PKC-activating phorbol myristate acetate (PMA) on Ras-dependent activation of transcription from the ets/AP-1 Ras-responsive promoter element were examined in human T cells.	Tetradecanoylphorbol Acetate	72-75	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	135-139
8689410-15	1996	CONCLUSIONS: These results indicate that both PMA and ionomycin stimulate HSF1, but not HSF2, translocation and synthesis leading to the HSP-70 expression and that their effects are Ca(2+)-dependent.	Tetradecanoylphorbol Acetate	46-49	heat shock transcription factor 1	Homo sapiens	74-78
9156516-12	1996	Co-incubation with PMA (100 nM) further enhanced the ACTH response to CRH-41 and forskolin; the effects were simply additive.	Tetradecanoylphorbol Acetate	19-22	pro-opiomelanocortin-alpha	Mus musculus	53-57
10599999-1	1999	In the present study, exposure of human peripheral blood mononuclear cells (PBMC) to phorbol 12-myristate 13-acetate (PMA) was found to elicit the expression of CD14 on lymphocytes.	Tetradecanoylphorbol Acetate	118-121	CD14 molecule	Homo sapiens	161-165
10599999-3	1999	Within two days of exposure of PBMC to PMA, up to 30% of the lymphocytes reacted with the 63D3 anti-CD14 mAb, though not with the LeuM3 and My4 anti-CD14 mAbs.	Tetradecanoylphorbol Acetate	39-42	CD14 molecule	Homo sapiens	100-104
8642843-2	1996	Phorbol esters which differentially activate PKC isoenzymes in vitro were used to induce differentiation and apoptosis in U937 cells; TPA and Dopp activate all U937 PKC isoenzymes, except PKC-zeta and Doppa activate only PKC-beta l. At concentrations of Doppa below 50 nM, only PKC-beta l was activated by 2 min and apoptosis was induced, but there was no differentiation of cells towards monocytes.	Tetradecanoylphorbol Acetate	134-137	protein kinase C beta	Homo sapiens	45-48
8642843-2	1996	Phorbol esters which differentially activate PKC isoenzymes in vitro were used to induce differentiation and apoptosis in U937 cells; TPA and Dopp activate all U937 PKC isoenzymes, except PKC-zeta and Doppa activate only PKC-beta l. At concentrations of Doppa below 50 nM, only PKC-beta l was activated by 2 min and apoptosis was induced, but there was no differentiation of cells towards monocytes.	Tetradecanoylphorbol Acetate	134-137	protein kinase C beta	Homo sapiens	165-168
8642843-2	1996	Phorbol esters which differentially activate PKC isoenzymes in vitro were used to induce differentiation and apoptosis in U937 cells; TPA and Dopp activate all U937 PKC isoenzymes, except PKC-zeta and Doppa activate only PKC-beta l. At concentrations of Doppa below 50 nM, only PKC-beta l was activated by 2 min and apoptosis was induced, but there was no differentiation of cells towards monocytes.	Tetradecanoylphorbol Acetate	134-137	protein kinase C beta	Homo sapiens	221-229
8642843-2	1996	Phorbol esters which differentially activate PKC isoenzymes in vitro were used to induce differentiation and apoptosis in U937 cells; TPA and Dopp activate all U937 PKC isoenzymes, except PKC-zeta and Doppa activate only PKC-beta l. At concentrations of Doppa below 50 nM, only PKC-beta l was activated by 2 min and apoptosis was induced, but there was no differentiation of cells towards monocytes.	Tetradecanoylphorbol Acetate	134-137	protein kinase C beta	Homo sapiens	278-286
9506849-7	1998	Cell exposure to difluoromethylornithine, an irreversible inhibitor of ODC enzyme, dramatically antagonised both serum- and phorbol 12-myristate 13-acetate (PMA)-stimulated DNA synthesis.	Tetradecanoylphorbol Acetate	124-155	ornithine decarboxylase 1	Homo sapiens	71-74
9506849-7	1998	Cell exposure to difluoromethylornithine, an irreversible inhibitor of ODC enzyme, dramatically antagonised both serum- and phorbol 12-myristate 13-acetate (PMA)-stimulated DNA synthesis.	Tetradecanoylphorbol Acetate	157-160	ornithine decarboxylase 1	Homo sapiens	71-74
10523655-1	1999	Downregulation of protein kinase C delta (PKC delta) by treatment with the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) transforms cells that overexpress the non-receptor class tyrosine kinase c-Src (Z. Lu et al., Mol.	Tetradecanoylphorbol Acetate	105-141	protein kinase C delta	Homo sapiens	18-40
8657115-6	1996	Moreover, PMA caused the dephosphorylation of Tyk2 but not of Jak1, which was activated by IFN.	Tetradecanoylphorbol Acetate	10-13	tyrosine kinase 2	Homo sapiens	46-50
10523655-1	1999	Downregulation of protein kinase C delta (PKC delta) by treatment with the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) transforms cells that overexpress the non-receptor class tyrosine kinase c-Src (Z. Lu et al., Mol.	Tetradecanoylphorbol Acetate	105-141	protein kinase C delta	Homo sapiens	42-51
8737382-5	1996	Phorbol-12-myristate-13-acetate (PMA) also strongly induced ODC activity in a transient manner, and additively to the effect of IGF-1.	Tetradecanoylphorbol Acetate	0-31	ornithine decarboxylase 1	Homo sapiens	60-63
10523655-1	1999	Downregulation of protein kinase C delta (PKC delta) by treatment with the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) transforms cells that overexpress the non-receptor class tyrosine kinase c-Src (Z. Lu et al., Mol.	Tetradecanoylphorbol Acetate	143-146	protein kinase C delta	Homo sapiens	18-40
8737382-5	1996	Phorbol-12-myristate-13-acetate (PMA) also strongly induced ODC activity in a transient manner, and additively to the effect of IGF-1.	Tetradecanoylphorbol Acetate	33-36	ornithine decarboxylase 1	Homo sapiens	60-63
9452447-7	1998	Phorbol 12-myristate 13-acetate, an agonist of PKC, mimics glucose-induced inhibition of IL-1 release.	Tetradecanoylphorbol Acetate	0-31	interleukin 1 complex	Mus musculus	89-93
10523655-1	1999	Downregulation of protein kinase C delta (PKC delta) by treatment with the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) transforms cells that overexpress the non-receptor class tyrosine kinase c-Src (Z. Lu et al., Mol.	Tetradecanoylphorbol Acetate	143-146	protein kinase C delta	Homo sapiens	42-51
8636154-3	1996	We have investigated changes in activity and expression of both IRP1 and IRP2 during phorbol 12-myristate 13-acetate (PMA)-induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	85-116	aconitase 1	Homo sapiens	64-68
8636154-3	1996	We have investigated changes in activity and expression of both IRP1 and IRP2 during phorbol 12-myristate 13-acetate (PMA)-induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	118-121	aconitase 1	Homo sapiens	64-68
10523861-1	1999	Activator protein 1 (AP-1) transactivation and ornithine decarboxylase (ODC) activity have been established as essential downstream effectors of mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	175-211	jun proto-oncogene	Mus musculus	0-19
9583193-4	1998	The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor alpha chain (IL-2R/CD25) was significantly suppressed; however, the addition of phorbol 12-myristate 13-acetate or ionomycin caused a remarkable recovery of CD25 expression.	Tetradecanoylphorbol Acetate	158-189	interleukin 2 receptor subunit alpha	Homo sapiens	91-96
10523861-1	1999	Activator protein 1 (AP-1) transactivation and ornithine decarboxylase (ODC) activity have been established as essential downstream effectors of mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	175-211	jun proto-oncogene	Mus musculus	21-25
9583193-4	1998	The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor alpha chain (IL-2R/CD25) was significantly suppressed; however, the addition of phorbol 12-myristate 13-acetate or ionomycin caused a remarkable recovery of CD25 expression.	Tetradecanoylphorbol Acetate	158-189	interleukin 2 receptor subunit alpha	Homo sapiens	97-101
9583193-4	1998	The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor alpha chain (IL-2R/CD25) was significantly suppressed; however, the addition of phorbol 12-myristate 13-acetate or ionomycin caused a remarkable recovery of CD25 expression.	Tetradecanoylphorbol Acetate	158-189	interleukin 2 receptor subunit alpha	Homo sapiens	235-239
8621459-2	1996	hSOS1 was phosphorylated in cells stimulated with EGF or phorbol 12-myristate 13-acetate or following co-transfection with activated Ras or Raf.	Tetradecanoylphorbol Acetate	57-88	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	0-5
10516232-5	1999	In contrast, when insulin secretion was stimulated by the cholinergic agonist carbachol (100 micromol/l) or the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (1 micromol/l), both of which activate protein kinase C, leptin was without effect.	Tetradecanoylphorbol Acetate	126-162	leptin	Rattus norvegicus	220-226
8612636-4	1996	Treatment of the cells with phorbol 12-myristate 13-acetate (PMA) for 24 h resulted in a gradual decrease in the expression of the TfR mRNA.	Tetradecanoylphorbol Acetate	28-59	transferrin receptor	Homo sapiens	131-134
8612636-4	1996	Treatment of the cells with phorbol 12-myristate 13-acetate (PMA) for 24 h resulted in a gradual decrease in the expression of the TfR mRNA.	Tetradecanoylphorbol Acetate	61-64	transferrin receptor	Homo sapiens	131-134
9476903-7	1998	The combination of 12-O-tetradecanoyl-phorbol-11-acetate (TPA) and terbutaline stimulated secretion of [3H]phosphatidylcholine ([3H]PC), SP-A, and lysozyme, but not SP-D.	Tetradecanoylphorbol Acetate	58-61	surfactant protein D	Rattus norvegicus	165-169
9486215-2	1998	The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) inhibit expression of surfactant-associated proteins A and B (SP-A and SP-B), both important for normal surfactant function.	Tetradecanoylphorbol Acetate	91-128	surfactant protein A1	Homo sapiens	197-201
9486215-2	1998	The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) inhibit expression of surfactant-associated proteins A and B (SP-A and SP-B), both important for normal surfactant function.	Tetradecanoylphorbol Acetate	91-128	surfactant protein B	Homo sapiens	206-210
9486215-2	1998	The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) inhibit expression of surfactant-associated proteins A and B (SP-A and SP-B), both important for normal surfactant function.	Tetradecanoylphorbol Acetate	130-133	surfactant protein A1	Homo sapiens	197-201
8612636-8	1996	Our results showed that the binding of nuclear extracts to the TfR gene promoter region containing the TRE-like sequence was increased in PMA-treated cells.	Tetradecanoylphorbol Acetate	138-141	transferrin receptor	Homo sapiens	63-66
10519505-9	1999	Both ERKs were also activated by 4beta-phorbol 12-myristate 13-acetate, an activator of protein kinase C, and fluoroaluminate (AlF4-), respectively, but procaine did not affect ERK activation induced by these two substances.	Tetradecanoylphorbol Acetate	33-70	mitogen activated protein kinase 3	Rattus norvegicus	5-9
8600152-0	1996	Phorbol 12-myristate 13-acetate enhances nm23 gene expression in murine melanocytes but not in syngeneic B16-BL6 melanoma variants.	Tetradecanoylphorbol Acetate	0-31	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	41-45
10670749-9	1999	In the culture of synovial cells from RA and OA, PTHrP was produced in RA more than OA after phorbol 12-mysistate 13-acetate (TPA) stimulation.	Tetradecanoylphorbol Acetate	126-129	parathyroid hormone like hormone	Homo sapiens	49-54
8600152-7	1996	Expression of nm23 decreased about 2-fold when phorbol 12-myristate 13-acetate (PMA) was removed from Mel-ab cells, which induces these cells to become quiescent.	Tetradecanoylphorbol Acetate	47-78	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	14-18
8600152-7	1996	Expression of nm23 decreased about 2-fold when phorbol 12-myristate 13-acetate (PMA) was removed from Mel-ab cells, which induces these cells to become quiescent.	Tetradecanoylphorbol Acetate	80-83	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	14-18
8779927-6	1996	This effect is not specific to PI3K, since aggregation of phospholipase C-gamma 1 to the activated bFGF receptor is also decreased by PMA treatment.	Tetradecanoylphorbol Acetate	134-137	fibroblast growth factor 2	Rattus norvegicus	99-103
9486215-2	1998	The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) inhibit expression of surfactant-associated proteins A and B (SP-A and SP-B), both important for normal surfactant function.	Tetradecanoylphorbol Acetate	130-133	surfactant protein B	Homo sapiens	206-210
9519716-7	1998	Leptin (50 ng/ml) significantly inhibited insulin secretion induced by the phorbol ester phorbol 12-myristate 13-acetate (TPA) in the presence of Ca2+ but not in the absence of Ca2+.	Tetradecanoylphorbol Acetate	89-120	leptin	Rattus norvegicus	0-6
9519716-7	1998	Leptin (50 ng/ml) significantly inhibited insulin secretion induced by the phorbol ester phorbol 12-myristate 13-acetate (TPA) in the presence of Ca2+ but not in the absence of Ca2+.	Tetradecanoylphorbol Acetate	122-125	leptin	Rattus norvegicus	0-6
9519716-8	1998	Because TPA is known to activate protein kinase C (PKC), these present results suggest that leptin, at a physiological concentration, suppresses the second phase of insulin secretion by reducing activity of the Ca2+-dependent PKC isoform.	Tetradecanoylphorbol Acetate	8-11	leptin	Rattus norvegicus	92-98
10540223-10	1999	In subcellular fractions, Rac2 was found to translocate, along with p47phox and p67phox, from cytosol to plasma membrane-associated fractions following phorbol myristate acetate stimulation, while RhoGDI remained within cytosolic fractions.	Tetradecanoylphorbol Acetate	152-177	neutrophil cytosolic factor 2	Homo sapiens	80-87
9557948-8	1998	Combined with PMA, PGE2 can overcome the decrease induced by PMA of the CD3 expression and partially reduced the disappearance of the CD4 molecule.	Tetradecanoylphorbol Acetate	14-17	CD3 antigen, epsilon polypeptide	Mus musculus	72-75
8596491-6	1996	These results suggest that TPA, an activator of PKC, has a stimulatory effect on GRH-induced cAMP production and that, finally, TRH- and CRH-induced PKC activation may cause greater secretion of GH by enhancement of cAMP production in human GH-hypersecreting adenoma cells.	Tetradecanoylphorbol Acetate	27-30	gonadotropin releasing hormone 1	Homo sapiens	81-84
8596491-6	1996	These results suggest that TPA, an activator of PKC, has a stimulatory effect on GRH-induced cAMP production and that, finally, TRH- and CRH-induced PKC activation may cause greater secretion of GH by enhancement of cAMP production in human GH-hypersecreting adenoma cells.	Tetradecanoylphorbol Acetate	27-30	thyrotropin releasing hormone	Homo sapiens	128-131
8579606-5	1996	The suppressive effect of CT on hydroperoxide production was reversed by further addition of H7 or by pretreatment with phorbol 12-myristate 13-acetate for 24 h. These results suggest that CT prevents CCl4-induced oxyradical production and cellular damage through activation of protein kinase C in hepatocytes.	Tetradecanoylphorbol Acetate	120-151	calcitonin-related polypeptide alpha	Rattus norvegicus	26-28
10603431-3	1999	As a result, tPA activity was significantly increased in CA1-CA4 and the dentate gyrus after TMT injection.	Tetradecanoylphorbol Acetate	13-16	carbonic anhydrase 4	Mus musculus	61-64
9162439-4	1996	In red cell from NT, PMA-induced activation of PKC reduced K(m) for H(+) of NHE but it did not affect V(max) and K(m) for Na(+).	Tetradecanoylphorbol Acetate	21-24	solute carrier family 9 member C1	Homo sapiens	76-79
9427759-8	1998	This differential effect of D-type cyclins on v-Myb and c-Myb might help to explain the mechanism underlying the oncogenic activity of v-Myb, which appears to be a stronger transcriptional activator following the TPA-induced differentiation of transformed monoblasts when cyclin D1 and D2 are down-regulated.	Tetradecanoylphorbol Acetate	213-216	cyclin D1	Homo sapiens	272-281
10482348-8	1999	Thus, the results show that the effects of TPA and NGF on PKC isoforms are not coincident in synaptosomes, the 6 isoform being activated and not down-regulated by both treatments, whereas the gamma isoform is only down-regulated in the case of TPA, but presents sustained translocation with NGF, indicating that PKC isoform-specific degradation pathways exist in synaptic terminals.	Tetradecanoylphorbol Acetate	244-247	nerve growth factor	Rattus norvegicus	51-54
9651115-2	1998	We found that DNA synthesis was stimulated by 10 microM 8BrcAMP, and 1 microM Sp-cDBIMPS, two cAMP analogs, and also by 1 microM phorbol 12-myristate 13-acetate (PMA) and 100 microM 1,2-dioctanoyl-sn-glycerol, two PKC activators, and 10 nM [Cys23] human (h)PTHrP (24-35) amide in rabbit proximal tubule cells (PTC).	Tetradecanoylphorbol Acetate	129-160	parathyroid hormone like hormone	Homo sapiens	257-262
9651115-2	1998	We found that DNA synthesis was stimulated by 10 microM 8BrcAMP, and 1 microM Sp-cDBIMPS, two cAMP analogs, and also by 1 microM phorbol 12-myristate 13-acetate (PMA) and 100 microM 1,2-dioctanoyl-sn-glycerol, two PKC activators, and 10 nM [Cys23] human (h)PTHrP (24-35) amide in rabbit proximal tubule cells (PTC).	Tetradecanoylphorbol Acetate	162-165	parathyroid hormone like hormone	Homo sapiens	257-262
9704334-10	1998	Phorbol 12-myristate 13-acetate (PMA, 2 or 5 nM) protected CCE cells against apoptosis induced by the introduction of TGF-beta 1 and withdrawal of aFGF, bFGF or VEGF, while H7 (50 microM), but not HA1004 (50 microM), abrogated the protective effect of PMA on CCE apoptosis.	Tetradecanoylphorbol Acetate	0-31	transforming growth factor, beta 1	Mus musculus	118-128
8717538-6	1996	As already known, PTH in the presence of supramaximal concentrations of transforming growth factor-beta (TGF-beta) stimulated osteoblast growth; under these same conditions, AC/PKA agonists reproduced the stimulatory effect of PTH(1-34), whereas PMA became inhibitory.	Tetradecanoylphorbol Acetate	246-249	parathyroid hormone	Mus musculus	18-21
8717538-6	1996	As already known, PTH in the presence of supramaximal concentrations of transforming growth factor-beta (TGF-beta) stimulated osteoblast growth; under these same conditions, AC/PKA agonists reproduced the stimulatory effect of PTH(1-34), whereas PMA became inhibitory.	Tetradecanoylphorbol Acetate	246-249	parathyroid hormone	Mus musculus	227-230
8616950-3	1996	Similar to PMNL, monocytes obtained from IgA nephropathy (IgAN) seemed to be primed both non-specifically and specifically, as increased O2- generation was observed to N-formyl methionyl leucyl phenylalanine (FMLP) and phorbol myristate acetate (PMA), as well as IgA aggregates stimulants, respectively.	Tetradecanoylphorbol Acetate	219-244	IGAN1	Homo sapiens	41-56
8616950-3	1996	Similar to PMNL, monocytes obtained from IgA nephropathy (IgAN) seemed to be primed both non-specifically and specifically, as increased O2- generation was observed to N-formyl methionyl leucyl phenylalanine (FMLP) and phorbol myristate acetate (PMA), as well as IgA aggregates stimulants, respectively.	Tetradecanoylphorbol Acetate	219-244	IGAN1	Homo sapiens	58-62
8616950-3	1996	Similar to PMNL, monocytes obtained from IgA nephropathy (IgAN) seemed to be primed both non-specifically and specifically, as increased O2- generation was observed to N-formyl methionyl leucyl phenylalanine (FMLP) and phorbol myristate acetate (PMA), as well as IgA aggregates stimulants, respectively.	Tetradecanoylphorbol Acetate	246-249	IGAN1	Homo sapiens	41-56
8616950-3	1996	Similar to PMNL, monocytes obtained from IgA nephropathy (IgAN) seemed to be primed both non-specifically and specifically, as increased O2- generation was observed to N-formyl methionyl leucyl phenylalanine (FMLP) and phorbol myristate acetate (PMA), as well as IgA aggregates stimulants, respectively.	Tetradecanoylphorbol Acetate	246-249	IGAN1	Homo sapiens	58-62
9704334-10	1998	Phorbol 12-myristate 13-acetate (PMA, 2 or 5 nM) protected CCE cells against apoptosis induced by the introduction of TGF-beta 1 and withdrawal of aFGF, bFGF or VEGF, while H7 (50 microM), but not HA1004 (50 microM), abrogated the protective effect of PMA on CCE apoptosis.	Tetradecanoylphorbol Acetate	0-31	fibroblast growth factor 2	Mus musculus	153-157
9704334-10	1998	Phorbol 12-myristate 13-acetate (PMA, 2 or 5 nM) protected CCE cells against apoptosis induced by the introduction of TGF-beta 1 and withdrawal of aFGF, bFGF or VEGF, while H7 (50 microM), but not HA1004 (50 microM), abrogated the protective effect of PMA on CCE apoptosis.	Tetradecanoylphorbol Acetate	33-36	transforming growth factor, beta 1	Mus musculus	118-128
10479670-12	1999	Incubation of ECs with phorbol ester (PMA) significantly enhanced the secretion of TFPI and increased its activity on the cell surface, probably by preventing invagination of caveolae.	Tetradecanoylphorbol Acetate	38-41	tissue factor pathway inhibitor	Homo sapiens	83-87
9848099-6	1998	Furthermore, zymographic analysis revealed that noncytotoxic concentrations (&lt; 10 microM) of TAC-101 inhibited TPA-induced production of urokinase-type plasminogen activator (u-PA) and matrix metalloproteinase (MMP)-9 from tumor cells, which is considered to be associated with their invasive and metastatic potentials.	Tetradecanoylphorbol Acetate	114-117	matrix metallopeptidase 9	Mus musculus	188-220
8695223-6	1996	Treatment of NIH 3T3 cells with 100 ng/ml TPA and 10, 50 and 100 microM apigenin resulted in 50, 80 and 100% suppression of TPA-induced C-JUN expression, respectively.	Tetradecanoylphorbol Acetate	42-45	jun proto-oncogene	Mus musculus	136-141
8695223-6	1996	Treatment of NIH 3T3 cells with 100 ng/ml TPA and 10, 50 and 100 microM apigenin resulted in 50, 80 and 100% suppression of TPA-induced C-JUN expression, respectively.	Tetradecanoylphorbol Acetate	124-127	jun proto-oncogene	Mus musculus	136-141
10479670-13	1999	Heparin-stimulated release of TFPI decreased significantly in the presence of PMA to a level that was 2.	Tetradecanoylphorbol Acetate	78-81	tissue factor pathway inhibitor	Homo sapiens	30-34
10596452-9	1999	All these agents and phorbol myristate acetate (PMA) induce alpha 1b-adrenoceptor phosphorylation.	Tetradecanoylphorbol Acetate	21-46	adrenoceptor alpha 1B	Rattus norvegicus	60-81
8551219-7	1996	Despite these structural similarities, differences are seen in the way phorbol myristate acetate, interleukin 1, TNF, and various metabolic inhibitors influence the cellular responsiveness to CD40, p55TNFR, and Fas-mediated killing.	Tetradecanoylphorbol Acetate	71-96	CD40 molecule	Homo sapiens	192-196
10491144-5	1999	Our data show that transcription of pol beta mRNA is induced by Ca2+ and that CsA significantly inhibits PMA/ionomycin- and ionomycin-mediated upregulation of both pol beta mRNA and Pol beta protein.	Tetradecanoylphorbol Acetate	105-108	DNA polymerase beta	Homo sapiens	36-44
8824897-4	1995	(Bu)2cAMP, AII, K+, BAYK8644 (a calcium channel agonist) and TPA are all shown to induce StAR.	Tetradecanoylphorbol Acetate	61-64	steroidogenic acute regulatory protein	Homo sapiens	89-93
8530489-5	1995	The presence of EGFRvIII suppresses activation of p42 and p44 MAP kinases by phorbol 12-myristate 13-acetate (PMA) and serum; however, MEK activation by PMA is not suppressed by EGFRvIII.	Tetradecanoylphorbol Acetate	77-108	interferon induced protein 44	Homo sapiens	58-61
9407126-1	1997	Bryostatin 1 (Bryo) has been shown to induce biphasic dose-response curves for down-regulating protein kinase Cdelta (PKCdelta) as well as for protecting PKCdelta from down-regulation induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	195-226	protein kinase C delta	Homo sapiens	154-162
9434740-6	1997	Induction of the MnSOD mRNA by phorbol-12-myristate-13-acetate (PMA) was only slightly diminished in the presence of PDTC, which in contrast virtually eliminated induction of the NF kappa B-dependent transcript I kappa B-alpha by PMA.	Tetradecanoylphorbol Acetate	31-62	superoxide dismutase 2	Homo sapiens	17-22
9434740-6	1997	Induction of the MnSOD mRNA by phorbol-12-myristate-13-acetate (PMA) was only slightly diminished in the presence of PDTC, which in contrast virtually eliminated induction of the NF kappa B-dependent transcript I kappa B-alpha by PMA.	Tetradecanoylphorbol Acetate	64-67	superoxide dismutase 2	Homo sapiens	17-22
9434740-10	1997	In vitro DNA binding studies confirmed strong AP-1 activation under conditions where NF kappa B is blocked but the MnSOD transcript is strongly induced (e.g., PMA treatment in the presence of PDTC).	Tetradecanoylphorbol Acetate	159-162	superoxide dismutase 2	Homo sapiens	115-120
8530489-5	1995	The presence of EGFRvIII suppresses activation of p42 and p44 MAP kinases by phorbol 12-myristate 13-acetate (PMA) and serum; however, MEK activation by PMA is not suppressed by EGFRvIII.	Tetradecanoylphorbol Acetate	110-113	interferon induced protein 44	Homo sapiens	58-61
10491144-5	1999	Our data show that transcription of pol beta mRNA is induced by Ca2+ and that CsA significantly inhibits PMA/ionomycin- and ionomycin-mediated upregulation of both pol beta mRNA and Pol beta protein.	Tetradecanoylphorbol Acetate	105-108	DNA polymerase beta	Homo sapiens	164-172
10491144-5	1999	Our data show that transcription of pol beta mRNA is induced by Ca2+ and that CsA significantly inhibits PMA/ionomycin- and ionomycin-mediated upregulation of both pol beta mRNA and Pol beta protein.	Tetradecanoylphorbol Acetate	105-108	DNA polymerase beta	Homo sapiens	182-190
9434623-3	1997	In addition, the signal for collagenase expression in response to phorbol-12 myristate-13 acetate (PMA) or to agents which alter cell shape in early passage fibroblast cultures is routed extracellularly to an autocrine cytokine intermediate, IL-1 alpha.	Tetradecanoylphorbol Acetate	66-97	interleukin-1 alpha	Oryctolagus cuniculus	242-252
9434623-3	1997	In addition, the signal for collagenase expression in response to phorbol-12 myristate-13 acetate (PMA) or to agents which alter cell shape in early passage fibroblast cultures is routed extracellularly to an autocrine cytokine intermediate, IL-1 alpha.	Tetradecanoylphorbol Acetate	99-102	interleukin-1 alpha	Oryctolagus cuniculus	242-252
10454561-5	1999	In the present study, we demonstrate that expression of TD-IkappaBalpha blocked phorbol myristate acetate-phytohemagglutinin or tumor necrosis factor alpha-induced IkappaBalpha gene transcription and abolished NF-kappaB DNA binding activity, due to the continued cytoplasmic sequestration of RelA(p65) by TD-IkappaBalpha.	Tetradecanoylphorbol Acetate	80-105	RELA proto-oncogene, NF-kB subunit	Homo sapiens	292-296
7493642-5	1995	We had previously observed that the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), which profoundly alters cell shape, markedly suppresses ODC biosynthesis in NHEK solely at posttranscriptional/protein synthesis levels.	Tetradecanoylphorbol Acetate	50-86	ornithine decarboxylase 1	Homo sapiens	150-153
7493642-5	1995	We had previously observed that the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), which profoundly alters cell shape, markedly suppresses ODC biosynthesis in NHEK solely at posttranscriptional/protein synthesis levels.	Tetradecanoylphorbol Acetate	88-91	ornithine decarboxylase 1	Homo sapiens	150-153
7493642-7	1995	Immunolocalization of ODC showed a perinuclear/nuclear distribution in untreated NHEK and a more diffuse pattern after TPA treatment that was apparent within 15-30 min.	Tetradecanoylphorbol Acetate	119-122	ornithine decarboxylase 1	Homo sapiens	22-25
7493642-8	1995	Changes in ODC enzyme activity are not significant until 60 min after TPA treatment.	Tetradecanoylphorbol Acetate	70-73	ornithine decarboxylase 1	Homo sapiens	11-14
9426245-7	1997	On the other hand, the gene expression of GDNF in C6 glioma cells was transiently induced by treatment with phorbol myristate acetate (PMA), but not by forskolin.	Tetradecanoylphorbol Acetate	108-133	glial cell line derived neurotrophic factor	Mus musculus	42-46
9426245-7	1997	On the other hand, the gene expression of GDNF in C6 glioma cells was transiently induced by treatment with phorbol myristate acetate (PMA), but not by forskolin.	Tetradecanoylphorbol Acetate	135-138	glial cell line derived neurotrophic factor	Mus musculus	42-46
10454561-5	1999	In the present study, we demonstrate that expression of TD-IkappaBalpha blocked phorbol myristate acetate-phytohemagglutinin or tumor necrosis factor alpha-induced IkappaBalpha gene transcription and abolished NF-kappaB DNA binding activity, due to the continued cytoplasmic sequestration of RelA(p65) by TD-IkappaBalpha.	Tetradecanoylphorbol Acetate	80-105	RELA proto-oncogene, NF-kB subunit	Homo sapiens	297-300
8566027-1	1995	As shown previously, a given cytotoxic T lymphocyte (CTL) clone (KB5.C20) could be induced to express the Fas ligand (FasL) by either T cell receptor (TCR) engagement or phorbol 12-myristate 13-acetate (PMA)/ionomycin stimulation.	Tetradecanoylphorbol Acetate	170-201	Fas ligand	Rattus norvegicus	106-116
10419544-3	1999	Membranes isolated from erythrocytes pretreated with 4beta-phorbol-12beta-myristate-13alpha-acetate (PMA) exhibited a decreased capacity for Galpha(11)-mediated activation of purified, reconstituted PLC-beta1.	Tetradecanoylphorbol Acetate	101-104	guanine nucleotide-binding protein subunit alpha-11	Meleagris gallopavo	141-151
8566027-1	1995	As shown previously, a given cytotoxic T lymphocyte (CTL) clone (KB5.C20) could be induced to express the Fas ligand (FasL) by either T cell receptor (TCR) engagement or phorbol 12-myristate 13-acetate (PMA)/ionomycin stimulation.	Tetradecanoylphorbol Acetate	170-201	Fas ligand	Rattus norvegicus	118-122
8566027-1	1995	As shown previously, a given cytotoxic T lymphocyte (CTL) clone (KB5.C20) could be induced to express the Fas ligand (FasL) by either T cell receptor (TCR) engagement or phorbol 12-myristate 13-acetate (PMA)/ionomycin stimulation.	Tetradecanoylphorbol Acetate	203-206	Fas ligand	Rattus norvegicus	106-116
8566027-1	1995	As shown previously, a given cytotoxic T lymphocyte (CTL) clone (KB5.C20) could be induced to express the Fas ligand (FasL) by either T cell receptor (TCR) engagement or phorbol 12-myristate 13-acetate (PMA)/ionomycin stimulation.	Tetradecanoylphorbol Acetate	203-206	Fas ligand	Rattus norvegicus	118-122
8848016-2	1995	In C6 glioma cells, short term (10 min) treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) results in a dose-dependent translocation of PKC alpha, PKC delta and PKC theta.	Tetradecanoylphorbol Acetate	55-92	protein kinase C delta	Homo sapiens	155-164
8848016-2	1995	In C6 glioma cells, short term (10 min) treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) results in a dose-dependent translocation of PKC alpha, PKC delta and PKC theta.	Tetradecanoylphorbol Acetate	94-97	protein kinase C delta	Homo sapiens	155-164
8848016-3	1995	Long term (24 hr) treatment with appropriate doses of TPA results in the complete down-regulation of PKC delta but not of PKC alpha PKC theta.	Tetradecanoylphorbol Acetate	54-57	protein kinase C delta	Homo sapiens	101-110
8848016-8	1995	We have shown that the Na(+)-H+ exchanger in C6 glioma cells can be stimulated by TPA-induced PKC activation and, for the first time, that PKC delta is involved in the activation of this antiporter.	Tetradecanoylphorbol Acetate	82-85	protein kinase C delta	Homo sapiens	139-148
7492301-7	1995	In addition, regulated mucin secretion by LS180 cells was studied in response to carbachol, phorbol 12-myristate 13-acetate and A23187.	Tetradecanoylphorbol Acetate	92-123	LOC100508689	Homo sapiens	23-28
7592840-5	1995	In contrast, TPA produced a sustained activation of A-Raf and only transiently activated c-Raf.	Tetradecanoylphorbol Acetate	13-16	A-Raf proto-oncogene, serine/threonine kinase	Rattus norvegicus	52-57
7592840-5	1995	In contrast, TPA produced a sustained activation of A-Raf and only transiently activated c-Raf.	Tetradecanoylphorbol Acetate	13-16	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	89-94
7592840-7	1995	TPA and ET1 were the most potent activators of c-Raf and A-Raf.	Tetradecanoylphorbol Acetate	0-3	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	47-52
7592840-7	1995	TPA and ET1 were the most potent activators of c-Raf and A-Raf.	Tetradecanoylphorbol Acetate	0-3	A-Raf proto-oncogene, serine/threonine kinase	Rattus norvegicus	57-62
7586191-5	1995	Skin hyperplasia induced by one topical application of TPA was accompanied by hyperexpression of both Cx26 and Cx43.	Tetradecanoylphorbol Acetate	55-58	gap junction protein, alpha 3	Mus musculus	111-115
8589452-3	1995	The current study investigates the mechanisms regulating the association of syndecan-4 with focal contacts based upon its immunolocalization with vinculin in quiescent, serum-stimulated, and 12-0-tetradecanoylphorbol 13-acetate (TPA)-induced cultures.	Tetradecanoylphorbol Acetate	229-232	syndecan 4	Homo sapiens	76-86
8589452-5	1995	However, activation of protein kinase C by TPA or serum induces the active recruitment of syndecan-4 into focal contacts.	Tetradecanoylphorbol Acetate	43-46	syndecan 4	Homo sapiens	90-100
7559652-12	1995	Prior down-regulation of signaling by 12-O-tetradecanoylphorbol-13-acetate and serum pretreatment reduced UV-stimulated rhoB expression.	Tetradecanoylphorbol Acetate	38-74	ras homolog family member B	Mus musculus	120-124
7554401-5	1995	Importantly, the levels of mRNA encoding c-myc, IL-2R alpha, IL-2 and IFN-gamma were markedly decreased in patient lymphocytes stimulated with PMA+ionomycin as compared to control lymphocytes.	Tetradecanoylphorbol Acetate	143-146	interleukin 2 receptor subunit alpha	Homo sapiens	48-59
7556527-3	1995	CD13 antigen was induced in all 10 cases of precursor-B ALL after culture with BCGF, with weaker expression seen in cells incubated with TPA or in medium alone.	Tetradecanoylphorbol Acetate	137-140	alanyl aminopeptidase, membrane	Homo sapiens	0-4
8568921-7	1995	In contrast, low concentrations of phorbol myristoyl acetate (PMA) or bryostatin, which activate protein kinase C activity, enhanced the staurosporine- or NGF-induced neurite extension.	Tetradecanoylphorbol Acetate	62-65	nerve growth factor	Rattus norvegicus	155-158
8572580-6	1995	TPA could also enhance the activity of asparagine synthetase within 24 h at concentrations of more than 10 nM.	Tetradecanoylphorbol Acetate	0-3	asparagine synthetase	Mus musculus	39-60
8519690-13	1995	Both aFGF and basic FGF (bFGF) promoted concentration-dependent enhancement of TPA-pretreated T5 cell thymidine incorporation, and the effects of combined TPA and either aFGF or bFGF treatment were additive.	Tetradecanoylphorbol Acetate	79-82	fibroblast growth factor 2	Rattus norvegicus	14-23
8519690-13	1995	Both aFGF and basic FGF (bFGF) promoted concentration-dependent enhancement of TPA-pretreated T5 cell thymidine incorporation, and the effects of combined TPA and either aFGF or bFGF treatment were additive.	Tetradecanoylphorbol Acetate	79-82	fibroblast growth factor 2	Rattus norvegicus	25-29
7649093-11	1995	The effect of GHRH on GHF-1 mRNA levels could be mimicked by direct activators of second messenger signaling systems such as forskolin (10(-5) M) or the phorbol ester tumor promoter tetradecanoyl phorbol acetate (TPA) (10(-6) M).	Tetradecanoylphorbol Acetate	213-216	growth hormone releasing hormone	Rattus norvegicus	14-18
7480087-0	1995	EGF and TPA stimulate de novo synthesis of PGHS-1 and PGHS-2 through different signal transduction pathways.	Tetradecanoylphorbol Acetate	8-11	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	43-49
7480087-0	1995	EGF and TPA stimulate de novo synthesis of PGHS-1 and PGHS-2 through different signal transduction pathways.	Tetradecanoylphorbol Acetate	8-11	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	54-60
7480087-1	1995	Epidermal growth factor (EGF) as well as phorbol 12-myristate 13-acetate (TPA) stimulate de novo synthesis of PGHS (prostaglandin H synthase)-1 and PGHS-2 mRNA, resulting in increased production of PGE2 in rat tracheal epithelial cells (RTE, EGV-6 cells).	Tetradecanoylphorbol Acetate	41-72	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	148-154
7662698-4	1995	Heavy staining with the antibody for autophosphorylated CaMK II was observed in the cytoplasm of chief cells treated with carbamylcholine chloride or ionomycin, but only light staining was seen in cells treated with TPA or forskolin.	Tetradecanoylphorbol Acetate	216-219	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	56-63
7635577-1	1995	The secretion of TGF-alpha was enhanced by phorbol 12-myristate 13-acetate (PMA), indicating the possible role of protein kinase C (PKC) in the formation of mature TGF-alpha.	Tetradecanoylphorbol Acetate	43-74	transforming growth factor alpha	Homo sapiens	17-26
7635577-1	1995	The secretion of TGF-alpha was enhanced by phorbol 12-myristate 13-acetate (PMA), indicating the possible role of protein kinase C (PKC) in the formation of mature TGF-alpha.	Tetradecanoylphorbol Acetate	76-79	transforming growth factor alpha	Homo sapiens	17-26
7635577-1	1995	The secretion of TGF-alpha was enhanced by phorbol 12-myristate 13-acetate (PMA), indicating the possible role of protein kinase C (PKC) in the formation of mature TGF-alpha.	Tetradecanoylphorbol Acetate	76-79	protein kinase C beta	Homo sapiens	132-135
7635577-1	1995	The secretion of TGF-alpha was enhanced by phorbol 12-myristate 13-acetate (PMA), indicating the possible role of protein kinase C (PKC) in the formation of mature TGF-alpha.	Tetradecanoylphorbol Acetate	76-79	transforming growth factor alpha	Homo sapiens	164-173
7635577-7	1995	Calphostin C, an inhibitor of PKC, reduced the enzyme activity and significantly inhibited the PMA-induced secretion of TGF-alpha by both cell lines.	Tetradecanoylphorbol Acetate	95-98	protein kinase C beta	Homo sapiens	30-33
7635577-7	1995	Calphostin C, an inhibitor of PKC, reduced the enzyme activity and significantly inhibited the PMA-induced secretion of TGF-alpha by both cell lines.	Tetradecanoylphorbol Acetate	95-98	transforming growth factor alpha	Homo sapiens	120-129
7645620-8	1995	Interleukin-4 at 10 ng/ml and phorbol 12-myristate 13-acetate at 10(-7) mol/L significantly increased the secretion of parathyroid hormone-related peptide by human umbilical vein endothelial cells (p &lt; 0.05).	Tetradecanoylphorbol Acetate	30-61	parathyroid hormone like hormone	Homo sapiens	119-154
8535398-4	1995	Serotonin-induced cyclic GMP formation was completely inhibited by pretreatment with 100 nM 12-o-tetradecanoylphorbol 13-acetate (TPA), although that induced by ANP was only partially inhibited and the effects were blocked by pretreatment with staurosporin.	Tetradecanoylphorbol Acetate	92-128	5'-nucleotidase, cytosolic II	Mus musculus	25-28
8535398-4	1995	Serotonin-induced cyclic GMP formation was completely inhibited by pretreatment with 100 nM 12-o-tetradecanoylphorbol 13-acetate (TPA), although that induced by ANP was only partially inhibited and the effects were blocked by pretreatment with staurosporin.	Tetradecanoylphorbol Acetate	130-133	5'-nucleotidase, cytosolic II	Mus musculus	25-28
21552848-5	1995	Enhancement of AP-1 activity by TPA increased the formation of anchorage independent colonies by tumorigenic RT101 cells.	Tetradecanoylphorbol Acetate	32-35	jun proto-oncogene	Mus musculus	15-19
9388261-8	1997	The binding of (p65)2 and/or c-Rel/p65 to the A2 probe was also detected from 12-o-tetradecanoylphorbol 13-acetate-stimulated HeLa, HOS, and A172 cells in which expression of MCP-1 mRNA was elevated.	Tetradecanoylphorbol Acetate	78-114	RELA proto-oncogene, NF-kB subunit	Homo sapiens	16-19
9388261-8	1997	The binding of (p65)2 and/or c-Rel/p65 to the A2 probe was also detected from 12-o-tetradecanoylphorbol 13-acetate-stimulated HeLa, HOS, and A172 cells in which expression of MCP-1 mRNA was elevated.	Tetradecanoylphorbol Acetate	78-114	RELA proto-oncogene, NF-kB subunit	Homo sapiens	35-38
9461041-3	1997	In 1% fetal calf serum (FCS), 20% of HL-60/MCSFR4D2 cells exhibited adherence after treatment with 0.5 ng/ml PMA for 48 h, 60% exhibited adherence after treatment with 1.0 ng/ml PMA and 80% exhibited adherence after treatment with 5.0 ng/ml PMA, while HL-60 cells exhibited only a slight response.	Tetradecanoylphorbol Acetate	109-112	colony stimulating factor 1 receptor	Homo sapiens	43-48
9461041-4	1997	Furthermore, antisense PTP1C oligonucleotides decreased the PMA-induced adherence of HL-60/MCSFR4D2 cells.	Tetradecanoylphorbol Acetate	60-63	colony stimulating factor 1 receptor	Homo sapiens	91-96
9432015-3	1997	Using RT-PCR, IL-5 mRNA was expressed by BMEC after stimulation (12 h) with lipopolysaccharide (LPS), IL-1, IL-2 and phorbol myristate acetate (PMA), but not by resting BMEC, after stimulation with TNF-alpha or interferon (IFN)-gamma.	Tetradecanoylphorbol Acetate	117-142	interleukin 5	Homo sapiens	14-18
9432015-3	1997	Using RT-PCR, IL-5 mRNA was expressed by BMEC after stimulation (12 h) with lipopolysaccharide (LPS), IL-1, IL-2 and phorbol myristate acetate (PMA), but not by resting BMEC, after stimulation with TNF-alpha or interferon (IFN)-gamma.	Tetradecanoylphorbol Acetate	144-147	interleukin 5	Homo sapiens	14-18
9428793-8	1997	In cells that have been preincubated to lower mRNA levels, there is a transient increase in G0S2 mRNA, peaking between 1-2 h, in response to Concanavalin-A (ConA), or to the combination of phorbol ester (TPA), and the calcium ionophore, ionomycin.	Tetradecanoylphorbol Acetate	204-207	G0/G1 switch 2	Homo sapiens	92-96
9497498-3	1997	Murine mast cells were found to adhere to both mLN and hLN and to merosin, not only following exposure to phorbol 12-myristate 13-acetate (PMA), but also after Fc epsilon RI aggregation or addition of stem cell factor (SCF).	Tetradecanoylphorbol Acetate	106-137	myoregulin	Mus musculus	47-50
9497498-3	1997	Murine mast cells were found to adhere to both mLN and hLN and to merosin, not only following exposure to phorbol 12-myristate 13-acetate (PMA), but also after Fc epsilon RI aggregation or addition of stem cell factor (SCF).	Tetradecanoylphorbol Acetate	106-137	laminin, alpha 2	Mus musculus	66-73
9497498-3	1997	Murine mast cells were found to adhere to both mLN and hLN and to merosin, not only following exposure to phorbol 12-myristate 13-acetate (PMA), but also after Fc epsilon RI aggregation or addition of stem cell factor (SCF).	Tetradecanoylphorbol Acetate	139-142	myoregulin	Mus musculus	47-50
9497498-3	1997	Murine mast cells were found to adhere to both mLN and hLN and to merosin, not only following exposure to phorbol 12-myristate 13-acetate (PMA), but also after Fc epsilon RI aggregation or addition of stem cell factor (SCF).	Tetradecanoylphorbol Acetate	139-142	laminin, alpha 2	Mus musculus	66-73
9353351-8	1997	The regulatory domain of PKCepsilon enhanced cell growth in the absence or presence of phorbol 12-myristate 13-acetate (PMA), and, in the presence of PMA, all chimeras with the PKCepsilon regulatory domain also gave rise to colonies in soft agar; the role of the catalytic domain of PKCepsilon was evident in the PMA-treated cells that overexpressed the PKC chimera containing the delta regulatory and the epsilon catalytic domains (PKCdelta/epsilon).	Tetradecanoylphorbol Acetate	87-118	protein kinase C, epsilon	Mus musculus	25-35
9353351-9	1997	The important contribution of the PKCepsilon catalytic domain to the growth of PKCdelta/epsilon-expressing cells was also evident in terms of a significantly increased saturation density in the presence of PMA, their formation of foci upon PMA treatment, and the induction of anchorage-independent growth.	Tetradecanoylphorbol Acetate	206-209	protein kinase C, epsilon	Mus musculus	34-44
9345026-4	1997	In contrast, the level of cyclin E protein remains unchanged and in a complex with cdk2 during the entire course of PMA treatment.	Tetradecanoylphorbol Acetate	116-119	cyclin dependent kinase 2	Homo sapiens	83-87
9395207-8	1997	Furthermore, zymographyic analysis showed that TPA treatment of BALB/3T3 cells induced secretion of gelatinase B and stromelysin-1 into the culture medium.	Tetradecanoylphorbol Acetate	47-50	matrix metallopeptidase 9	Mus musculus	100-112
9420139-0	1997	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol 12myristate 13acetate activated CD4+ CD23+ T-cell subset.	Tetradecanoylphorbol Acetate	87-116	Fc epsilon receptor II	Homo sapiens	132-136
9348199-4	1997	We also found that treatment of L6 myotubes with 5 microM tetradecanoyl phorbol-13-acetate (TPA) for 24 h led to 80-100% losses of all DAG-dependent PKCs (alpha, beta1, beta2, delta, epsilon) and TPA-stimulated glucose transport (2-deoxyglucose uptake); in contrast, there was full retention of PKC-zeta, as well as insulin-stimulated glucose transport and translocation of GLUT4 and GLUT1 to the plasma membrane.	Tetradecanoylphorbol Acetate	92-95	solute carrier family 2 member 1	Rattus norvegicus	384-389
12386374-1	1997	That mammalian DNA polymerase-beta (beta-pol) gene transcription is upregulated by activated ras and also by phorbol ester (TPA) treatment suggests the involvement of protein kinase C in the gene expression control for this DNA repair enzyme.	Tetradecanoylphorbol Acetate	124-127	DNA polymerase beta	Homo sapiens	15-34
9367839-5	1997	Although HGF did not detectably influence the proliferation or morphology of HMC-1 cells, HGF inhibited the cells" ability to release tumor necrosis factor-alpha (TNF-alpha) in response to stimulation with PMA and the calcium ionophore, A23187.	Tetradecanoylphorbol Acetate	206-209	hepatocyte growth factor	Homo sapiens	90-93
9341140-6	1997	Interruption of the ERK-related pathway using expression vectors for kinase-deficient ERKs or an ERK-specific phosphatase (PAC-1) blocked gastrin- and PMA-stimulated HDC promoter activity.	Tetradecanoylphorbol Acetate	151-154	histidine decarboxylase	Homo sapiens	166-169
9349751-6	1997	In addition, PMA inhibited hCG- and CRH-stimulated steroidogenesis in MA-10 cells and CRH-stimulated steroidogenesis in primary Leydig cells, suggesting that activation of the protein kinase C pathway can influence protein kinase A stimulated steroidogenesis.	Tetradecanoylphorbol Acetate	13-16	hypertrichosis 2 (generalised, congenital)	Homo sapiens	27-31
9278304-2	1997	Engagement of the CD28 receptor by soluble anti-CD28 mAb in conjunction with phorbol ester (PMA) induces the production of cytokines and the proliferation of resting T cells via signal transduction pathways independent of the TCR.	Tetradecanoylphorbol Acetate	92-95	CD28 molecule	Homo sapiens	18-22
9252399-3	1997	Responsiveness to 12-O-tetradecanoylphorbol-13-acetate (TPA) localized to the SP-B proximal promoter (-140/-65 bp) and specifically to binding sites for TTF-1 and HNF3, which act as cell-specific enhancers of SP-B expression.	Tetradecanoylphorbol Acetate	18-54	surfactant protein B	Homo sapiens	78-82
9252399-3	1997	Responsiveness to 12-O-tetradecanoylphorbol-13-acetate (TPA) localized to the SP-B proximal promoter (-140/-65 bp) and specifically to binding sites for TTF-1 and HNF3, which act as cell-specific enhancers of SP-B expression.	Tetradecanoylphorbol Acetate	18-54	surfactant protein B	Homo sapiens	209-213
9252399-3	1997	Responsiveness to 12-O-tetradecanoylphorbol-13-acetate (TPA) localized to the SP-B proximal promoter (-140/-65 bp) and specifically to binding sites for TTF-1 and HNF3, which act as cell-specific enhancers of SP-B expression.	Tetradecanoylphorbol Acetate	56-59	surfactant protein B	Homo sapiens	78-82
9252399-3	1997	Responsiveness to 12-O-tetradecanoylphorbol-13-acetate (TPA) localized to the SP-B proximal promoter (-140/-65 bp) and specifically to binding sites for TTF-1 and HNF3, which act as cell-specific enhancers of SP-B expression.	Tetradecanoylphorbol Acetate	56-59	surfactant protein B	Homo sapiens	209-213
9294011-1	1997	Phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) activate protein kinase C and have been previously shown to down-regulate surfactant proteins SP-A and SP-B in H441 adenocarcinoma cells.	Tetradecanoylphorbol Acetate	23-59	surfactant protein A1	Homo sapiens	160-164
9294011-1	1997	Phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) activate protein kinase C and have been previously shown to down-regulate surfactant proteins SP-A and SP-B in H441 adenocarcinoma cells.	Tetradecanoylphorbol Acetate	23-59	surfactant protein B	Homo sapiens	169-173
9294011-1	1997	Phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) activate protein kinase C and have been previously shown to down-regulate surfactant proteins SP-A and SP-B in H441 adenocarcinoma cells.	Tetradecanoylphorbol Acetate	61-64	surfactant protein A1	Homo sapiens	160-164
9294011-1	1997	Phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) activate protein kinase C and have been previously shown to down-regulate surfactant proteins SP-A and SP-B in H441 adenocarcinoma cells.	Tetradecanoylphorbol Acetate	61-64	surfactant protein B	Homo sapiens	169-173
9294011-3	1997	In H441 cells, TPA (10 nM) treatment for 24 h decreased SP-A mRNA content to approximately 5% of control cells, with half-maximal effect at approximately 0.5 nM, and reduced SP-A gene transcription rate to 28% of control after 8 h exposure.	Tetradecanoylphorbol Acetate	15-18	surfactant protein A1	Homo sapiens	56-60
9294011-3	1997	In H441 cells, TPA (10 nM) treatment for 24 h decreased SP-A mRNA content to approximately 5% of control cells, with half-maximal effect at approximately 0.5 nM, and reduced SP-A gene transcription rate to 28% of control after 8 h exposure.	Tetradecanoylphorbol Acetate	15-18	surfactant protein A1	Homo sapiens	174-178
9294011-4	1997	In cells cultured in the presence of dexamethasone, which increases the low basal level of SP-B expression, TPA decreased both SP-B mRNA content (approximately 8% of control) and rate of transcription (7% of control).	Tetradecanoylphorbol Acetate	108-111	surfactant protein B	Homo sapiens	91-95
9294011-4	1997	In cells cultured in the presence of dexamethasone, which increases the low basal level of SP-B expression, TPA decreased both SP-B mRNA content (approximately 8% of control) and rate of transcription (7% of control).	Tetradecanoylphorbol Acetate	108-111	surfactant protein B	Homo sapiens	127-131
9294011-5	1997	In cultured human fetal lung explants, TPA decreased SP-A and SP-B protein and mRNA in a time- and dose-dependent fashion, with half-maximal effect on mRNAs at approximately 3 nM and approximately 50% inhibition after 24 h of exposure, and similarly reduced SP-A and SP-B gene transcription (approximately 55% of control at 8-24 h).	Tetradecanoylphorbol Acetate	39-42	surfactant protein A1	Homo sapiens	53-57
9294011-5	1997	In cultured human fetal lung explants, TPA decreased SP-A and SP-B protein and mRNA in a time- and dose-dependent fashion, with half-maximal effect on mRNAs at approximately 3 nM and approximately 50% inhibition after 24 h of exposure, and similarly reduced SP-A and SP-B gene transcription (approximately 55% of control at 8-24 h).	Tetradecanoylphorbol Acetate	39-42	surfactant protein B	Homo sapiens	62-66
9294011-5	1997	In cultured human fetal lung explants, TPA decreased SP-A and SP-B protein and mRNA in a time- and dose-dependent fashion, with half-maximal effect on mRNAs at approximately 3 nM and approximately 50% inhibition after 24 h of exposure, and similarly reduced SP-A and SP-B gene transcription (approximately 55% of control at 8-24 h).	Tetradecanoylphorbol Acetate	39-42	surfactant protein A1	Homo sapiens	258-262
9294011-5	1997	In cultured human fetal lung explants, TPA decreased SP-A and SP-B protein and mRNA in a time- and dose-dependent fashion, with half-maximal effect on mRNAs at approximately 3 nM and approximately 50% inhibition after 24 h of exposure, and similarly reduced SP-A and SP-B gene transcription (approximately 55% of control at 8-24 h).	Tetradecanoylphorbol Acetate	39-42	surfactant protein B	Homo sapiens	267-271
9294011-6	1997	We conclude that TPA acts primarily at the level of gene transcription to down-regulate both SP-A and SP-B in H441 and fetal lung cells, and we speculate that inflammatory and other agents that act through PKC may modulate expression of the surfactant proteins and alter surfactant function in vivo.	Tetradecanoylphorbol Acetate	17-20	surfactant protein A1	Homo sapiens	93-97
9294011-6	1997	We conclude that TPA acts primarily at the level of gene transcription to down-regulate both SP-A and SP-B in H441 and fetal lung cells, and we speculate that inflammatory and other agents that act through PKC may modulate expression of the surfactant proteins and alter surfactant function in vivo.	Tetradecanoylphorbol Acetate	17-20	surfactant protein B	Homo sapiens	102-106
9241060-5	1997	Luteal ROS responses to PMA were quenched by returning bovine erythrocytes to purified luteal cells, or by exogenous catalase or superoxide dismutase.	Tetradecanoylphorbol Acetate	24-27	catalase	Bos taurus	117-125
9283699-10	1997	Staurosporine (64 nM) and TPA (49 nM) enhanced the level of CINC-3 mRNA time-dependently, but had no effect on GAPDH mRNA levels.	Tetradecanoylphorbol Acetate	26-29	C-X-C motif chemokine ligand 2	Rattus norvegicus	60-66
9283699-15	1997	Both the staurosporine- and the TPA-induced increase in CINC-3 mRNA levels were suppressed by H-7 and genistein.	Tetradecanoylphorbol Acetate	32-35	C-X-C motif chemokine ligand 2	Rattus norvegicus	56-62
9276765-11	1997	TPA-induced MPO increase was decreased by all COX-2 inhibitors.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	46-51
9244202-3	1997	METHODS AND RESULTS: Cultured NM were treated with phorbol-12-myristate-13-acetate (PMA), a compound that decreases endogenous SERCA2 expression and results in prolongation of EC-associated Ca2+ transients.	Tetradecanoylphorbol Acetate	51-82	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	127-133
9244202-3	1997	METHODS AND RESULTS: Cultured NM were treated with phorbol-12-myristate-13-acetate (PMA), a compound that decreases endogenous SERCA2 expression and results in prolongation of EC-associated Ca2+ transients.	Tetradecanoylphorbol Acetate	84-87	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	127-133
7476996-3	1995	By each method, the half-life of relatively short-lived LDH A mRNA was increased 5- to 7-fold in 8- (4-chloro-phenylthio) cAMP or forskolin-treated and about 3-fold in 12-0-tetradecanoylphorbol-13- acetate (TPA) or dioctanoylglycerol-treated cells.	Tetradecanoylphorbol Acetate	207-210	lactate dehydrogenase A	Rattus norvegicus	56-59
7476996-4	1995	Forskolin acted synergistically with TPA to prolong LDH A mRNA half-life from 55 min to more than 20 h. The relatively rapid basal decay rate of LDH A mRNA was also considerably slowed in the presence of the protein phosphatase inhibitor okadaic acid, suggesting a functional role for protein phosphorylation in the stabilization process.	Tetradecanoylphorbol Acetate	37-40	lactate dehydrogenase A	Rattus norvegicus	52-57
7476996-4	1995	Forskolin acted synergistically with TPA to prolong LDH A mRNA half-life from 55 min to more than 20 h. The relatively rapid basal decay rate of LDH A mRNA was also considerably slowed in the presence of the protein phosphatase inhibitor okadaic acid, suggesting a functional role for protein phosphorylation in the stabilization process.	Tetradecanoylphorbol Acetate	37-40	lactate dehydrogenase A	Rattus norvegicus	145-150
7675040-2	1995	IL-1 synergistically enhances the stimulatory effect of TPA on AP-1-mediated gene expression in this cell line.	Tetradecanoylphorbol Acetate	56-59	interleukin 1 complex	Mus musculus	0-4
7675040-4	1995	We found that IL-1 + TPA-treated cells contain significantly higher Jun B protein levels than cells treated with TPA alone.	Tetradecanoylphorbol Acetate	21-24	interleukin 1 complex	Mus musculus	14-18
7675040-4	1995	We found that IL-1 + TPA-treated cells contain significantly higher Jun B protein levels than cells treated with TPA alone.	Tetradecanoylphorbol Acetate	113-116	interleukin 1 complex	Mus musculus	14-18
7675040-9	1995	Thus, the stimulation of AP-1-mediated gene expression by IL-1 in EL4 cells is due to the promotion of Jun B protein accumulation that, in turn, facilitates Jun B heterodimerization with TPA-induced Fra-1 protein, thereby forming an active AP-1 complex.	Tetradecanoylphorbol Acetate	187-190	interleukin 1 complex	Mus musculus	58-62
7547506-2	1995	Prolonged treatment of RD cells with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induces growth arrest and myogenic differentiation as shown by the accumulation of alpha-actin and myosin light and heavy chains, without affecting the expression of MyoD and myogenin.	Tetradecanoylphorbol Acetate	74-110	myogenin	Homo sapiens	292-300
7642751-7	1995	In isolated microglia, mRNA(IL-3) was increased upon treatment with LPS, PHA, with the cytokines IL-1 or TNF-alpha, with retinoic acid, dbcAMP or the phorbol ester TPA.	Tetradecanoylphorbol Acetate	164-167	interleukin 3	Rattus norvegicus	28-32
7543177-2	1995	We observed that phorbol 12-myristate 13-acetate (PMA) arrested HIMeg-1 growth and induced expression of monocytic surface antigens CD11c and CD14, but not the megakaryocytic surface antigen CD14a.	Tetradecanoylphorbol Acetate	17-48	integrin subunit alpha X	Homo sapiens	132-137
7543177-2	1995	We observed that phorbol 12-myristate 13-acetate (PMA) arrested HIMeg-1 growth and induced expression of monocytic surface antigens CD11c and CD14, but not the megakaryocytic surface antigen CD14a.	Tetradecanoylphorbol Acetate	17-48	CD14 molecule	Homo sapiens	142-146
7543177-2	1995	We observed that phorbol 12-myristate 13-acetate (PMA) arrested HIMeg-1 growth and induced expression of monocytic surface antigens CD11c and CD14, but not the megakaryocytic surface antigen CD14a.	Tetradecanoylphorbol Acetate	50-53	integrin subunit alpha X	Homo sapiens	132-137
7543177-2	1995	We observed that phorbol 12-myristate 13-acetate (PMA) arrested HIMeg-1 growth and induced expression of monocytic surface antigens CD11c and CD14, but not the megakaryocytic surface antigen CD14a.	Tetradecanoylphorbol Acetate	50-53	CD14 molecule	Homo sapiens	142-146
10399964-3	1999	We have previously presented an in vitro two-dimensional cohort migration model, in which highly metastatic variant L-10 cells of human rectal adenocarcinoma cell line RCM-1 moved as coherent cell sheets when stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) or hepatocyte growth factor/scatter factor (HGF/SF).	Tetradecanoylphorbol Acetate	225-261	hepatocyte growth factor	Homo sapiens	312-318
7797589-8	1995	Treatment of WT transfected cells with 12-O-tetradecanoyl-phorbol-13-acetate or 8-bromo-cAMP increased insulin receptor phosphorylation by 3-fold.	Tetradecanoylphorbol Acetate	39-76	insulin receptor	Mus musculus	103-119
9274933-2	1997	Varying amounts of prostaglandin E2 were induced in WISH cells using either interleukin-1beta, tumor necrosis factor-alpha or phorbol 12-myristate 13-acetate, alone or in combination, or with okadaic acid as stimulants.	Tetradecanoylphorbol Acetate	126-157	NCK interacting protein with SH3 domain	Homo sapiens	52-56
10399964-4	1999	Pericellular deposition of EDA-containing fibronectin (EDA+FN) was essential for TPA-induced cohort migration.	Tetradecanoylphorbol Acetate	81-84	ectodysplasin A	Homo sapiens	27-30
10399964-4	1999	Pericellular deposition of EDA-containing fibronectin (EDA+FN) was essential for TPA-induced cohort migration.	Tetradecanoylphorbol Acetate	81-84	ectodysplasin A	Homo sapiens	55-61
7626451-9	1995	These results indicate that NF-IL6 is one of the nuclear factors which participate in TPA-mediated transcriptional enhancement of CYP 19 gene expression.	Tetradecanoylphorbol Acetate	86-89	CCAAT enhancer binding protein beta	Homo sapiens	28-34
10400659-6	1999	Moreover, depletion of protein kinase C activity by prolonged treatment with phorbol 12-myristate 13-acetate significantly inhibited the hypoxic induction of A2AR.	Tetradecanoylphorbol Acetate	77-108	adenosine A2a receptor	Rattus norvegicus	158-162
7784060-2	1995	Moreover, several clonal lines of preneoplastic JB6 cells derived from Balb/c mouse epidermal cultures (Colburn et al., 1978, 1979), upon treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA), become irreversibly oncogenic and concomitantly synthesize OPN at elevated levels (Smith and Denhardt, 1989).	Tetradecanoylphorbol Acetate	153-190	secreted phosphoprotein 1	Mus musculus	257-260
7784060-4	1995	We transfected TPA-promotable JB6 c141.5a cells with an expression vector containing mouse OPN cDNA in antisense orientation under transcriptional control of dexamethasone-inducible MMTV-LTR promoter.	Tetradecanoylphorbol Acetate	15-18	secreted phosphoprotein 1	Mus musculus	91-94
9301678-5	1997	Expression of the c-myc gene was down-regulated and c-jun and c-fms transcripts increased following exposure to 5-500 nM TPA.	Tetradecanoylphorbol Acetate	121-124	colony stimulating factor 1 receptor	Homo sapiens	62-67
9301678-6	1997	In contrast, exposure to 0.5 nM TPA decreased c-myc expression and increased c-jun transcripts only transiently between 4 and 8 h while little if any effect was detectable on c-fms mRNA expression and subsequent differentiation.	Tetradecanoylphorbol Acetate	32-35	colony stimulating factor 1 receptor	Homo sapiens	175-180
9199305-2	1997	Although IL-2Rbeta is constitutively expressed by lymphocytes, its expression can be further induced by a number of stimuli, including phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	135-166	interleukin 2 receptor subunit beta	Homo sapiens	9-18
9199305-2	1997	Although IL-2Rbeta is constitutively expressed by lymphocytes, its expression can be further induced by a number of stimuli, including phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	168-171	interleukin 2 receptor subunit beta	Homo sapiens	9-18
9207176-4	1997	Treatment of LAK cells with PMA caused a disappearance of cytotoxicity against Fas L5178Y tumor cells, while cytotoxicity against Fas+ transfectants was not affected by PMA treatment.	Tetradecanoylphorbol Acetate	28-31	Fas ligand (TNF superfamily, member 6)	Mus musculus	79-84
9192835-6	1997	Phorbol 12-myristate 13-acetate and 12(S)-hydroxyeicosatetraenoic acid, two activators of protein kinase C, stimulated adhesion of melanoma cells to immobilized fibronectin and PAC-1, a mAb to alphaIIb beta3.	Tetradecanoylphorbol Acetate	0-31	dual specificity phosphatase 2	Homo sapiens	177-182
9192835-8	1997	Phorbol 12-myristate 13-acetate-stimulated adhesion of WM 983B cells to PAC-1 was completely blocked by an RGD peptide, thus providing evidence that tumor cell adhesion to PAC-1 is mediated via the alphaIIb beta3 integrin but not the Fc receptor.	Tetradecanoylphorbol Acetate	0-31	dual specificity phosphatase 2	Homo sapiens	72-77
9192835-8	1997	Phorbol 12-myristate 13-acetate-stimulated adhesion of WM 983B cells to PAC-1 was completely blocked by an RGD peptide, thus providing evidence that tumor cell adhesion to PAC-1 is mediated via the alphaIIb beta3 integrin but not the Fc receptor.	Tetradecanoylphorbol Acetate	0-31	dual specificity phosphatase 2	Homo sapiens	172-177
9182576-6	1997	Thrombin and the phorbol ester, phorbol 12-myristate 13-acetate, also increased p125(FAK) tyrosine phosphorylation in HUVECs.	Tetradecanoylphorbol Acetate	32-63	protein tyrosine kinase 2	Homo sapiens	85-88
9196026-4	1997	While the expression of the TGM1 gene is markedly affected by the calcium concentration of the medium, all trans retinoic acid, vitamin D3, and TPA treatment, the expression of the RABGGTA gene was unaffected by these reagents.	Tetradecanoylphorbol Acetate	144-147	transglutaminase 1	Homo sapiens	28-32
9166410-11	1997	Addition of an antibody against the extracellular part of desmoglein-2 blocked the TPA effect, too.	Tetradecanoylphorbol Acetate	83-86	desmoglein 2	Homo sapiens	58-70
9166836-3	1997	By contrast, induction of cytoplasmic maturation, as judged by beta-thromboglobulin production and platelet factor 4 expression, was more prominent in TPA-treated cells than in nocodazole-treated cells.	Tetradecanoylphorbol Acetate	151-154	pro-platelet basic protein	Homo sapiens	63-83
9159159-5	1997	The results showed that the SR11302, an AP-1 inhibition-specific retinoid, and other AP-1 inhibitors such as trans-retinoic acid and fluocinolone acetonide, markedly inhibit both 12-O-tetradecanoylphorbol-13-acetate-induced papilloma formation and AP-1 activation in 7,12-dimethyl benz(a)anthracene-initiated mouse skin (P &lt; 0.05).	Tetradecanoylphorbol Acetate	179-215	jun proto-oncogene	Mus musculus	40-44
9159159-5	1997	The results showed that the SR11302, an AP-1 inhibition-specific retinoid, and other AP-1 inhibitors such as trans-retinoic acid and fluocinolone acetonide, markedly inhibit both 12-O-tetradecanoylphorbol-13-acetate-induced papilloma formation and AP-1 activation in 7,12-dimethyl benz(a)anthracene-initiated mouse skin (P &lt; 0.05).	Tetradecanoylphorbol Acetate	179-215	jun proto-oncogene	Mus musculus	85-89
9159159-5	1997	The results showed that the SR11302, an AP-1 inhibition-specific retinoid, and other AP-1 inhibitors such as trans-retinoic acid and fluocinolone acetonide, markedly inhibit both 12-O-tetradecanoylphorbol-13-acetate-induced papilloma formation and AP-1 activation in 7,12-dimethyl benz(a)anthracene-initiated mouse skin (P &lt; 0.05).	Tetradecanoylphorbol Acetate	179-215	jun proto-oncogene	Mus musculus	85-89
9129045-9	1997	Protein kinase C (PKC) activation with 100 nmol/L TPA (12-O-tetradecanoylphorbol 13-acetate) or incubation with interleukin-4 (10 ng/mL) prevented either dexamethasone- or fludarabine-induced proteolysis of PARP.	Tetradecanoylphorbol Acetate	50-53	collagen type XI alpha 2 chain	Homo sapiens	207-211
9129045-9	1997	Protein kinase C (PKC) activation with 100 nmol/L TPA (12-O-tetradecanoylphorbol 13-acetate) or incubation with interleukin-4 (10 ng/mL) prevented either dexamethasone- or fludarabine-induced proteolysis of PARP.	Tetradecanoylphorbol Acetate	55-91	collagen type XI alpha 2 chain	Homo sapiens	207-211
9174164-1	1997	RGS1 and RGS2 are members of a new class of regulators of G-protein signaling identified by their selective mRNA expression either in phorbol ester (TPA)-stimulated human B lymphocytes (RGS1/1R20/BL34) or in blood mononuclear cells treated with the T-cell lectin concanavalin A (ConA) and cycloheximide (RGS2/G0S8).	Tetradecanoylphorbol Acetate	149-152	regulator of G protein signaling 2	Homo sapiens	9-13
9163569-5	1997	Western blot analysis demonstrated that auranofin inhibited the induction of cyclooxygenase 2 by TPA, thapsigargin or A23187 at 4 and 20 h. The level of cyclooxygenase 1 did not change by treatment with these stimulators in the presence or absence of auranofin.	Tetradecanoylphorbol Acetate	97-100	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	77-93
9250823-2	1997	Exposure of Farage cells, derived from a human B-cell lymphoma, to phorbol 12-myristate 13-acetate (PMA) down-regulated CD21 and CD23 expression, while interleukin 4 (IL4) inhibited the expression of CD21 but augmented CD23 expression.	Tetradecanoylphorbol Acetate	67-98	Fc epsilon receptor II	Homo sapiens	129-133
9250823-2	1997	Exposure of Farage cells, derived from a human B-cell lymphoma, to phorbol 12-myristate 13-acetate (PMA) down-regulated CD21 and CD23 expression, while interleukin 4 (IL4) inhibited the expression of CD21 but augmented CD23 expression.	Tetradecanoylphorbol Acetate	67-98	Fc epsilon receptor II	Homo sapiens	219-223
9250823-2	1997	Exposure of Farage cells, derived from a human B-cell lymphoma, to phorbol 12-myristate 13-acetate (PMA) down-regulated CD21 and CD23 expression, while interleukin 4 (IL4) inhibited the expression of CD21 but augmented CD23 expression.	Tetradecanoylphorbol Acetate	100-103	Fc epsilon receptor II	Homo sapiens	129-133
9250823-2	1997	Exposure of Farage cells, derived from a human B-cell lymphoma, to phorbol 12-myristate 13-acetate (PMA) down-regulated CD21 and CD23 expression, while interleukin 4 (IL4) inhibited the expression of CD21 but augmented CD23 expression.	Tetradecanoylphorbol Acetate	100-103	Fc epsilon receptor II	Homo sapiens	219-223
9160089-7	1997	Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis.	Tetradecanoylphorbol Acetate	0-25	integrin subunit alpha L	Homo sapiens	84-89
9175633-5	1997	Tetradecanoyl phorbol acetate (TPA) and okadaic acid caused a striking increase in the levels of PTH-rP mRNAs, much greater than that evoked by forskolin, dibutyryl cAMP, or transforming growth factor-beta (TGF-beta).	Tetradecanoylphorbol Acetate	0-29	parathyroid hormone like hormone	Homo sapiens	97-103
9175633-5	1997	Tetradecanoyl phorbol acetate (TPA) and okadaic acid caused a striking increase in the levels of PTH-rP mRNAs, much greater than that evoked by forskolin, dibutyryl cAMP, or transforming growth factor-beta (TGF-beta).	Tetradecanoylphorbol Acetate	31-34	parathyroid hormone like hormone	Homo sapiens	97-103
9135074-6	1997	Adult HK1.IGF-1 mice developed spontaneous tumors following treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) alone and exhibited an exaggerated epidermal proliferative response following treatment with the tumor promoter compared to non transgenic littermates.	Tetradecanoylphorbol Acetate	75-111	insulin-like growth factor 1	Mus musculus	10-15
9135074-6	1997	Adult HK1.IGF-1 mice developed spontaneous tumors following treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) alone and exhibited an exaggerated epidermal proliferative response following treatment with the tumor promoter compared to non transgenic littermates.	Tetradecanoylphorbol Acetate	113-116	insulin-like growth factor 1	Mus musculus	10-15
9141617-4	1997	We observed a time-dependent upregulation of hPD-1 mRNA and protein levels in Jurkat cells during phorbol ester (12-O-tetradecanoylphorbol 13-acetate, TPA)-induced differentiation.	Tetradecanoylphorbol Acetate	113-149	programmed cell death 1	Homo sapiens	45-50
9141617-4	1997	We observed a time-dependent upregulation of hPD-1 mRNA and protein levels in Jurkat cells during phorbol ester (12-O-tetradecanoylphorbol 13-acetate, TPA)-induced differentiation.	Tetradecanoylphorbol Acetate	151-154	programmed cell death 1	Homo sapiens	45-50
9141617-6	1997	Additionally, TPA stimulation of Jurkat cells induces tyrosine phosphorylation of hPD-1, putatively on its cytoplasmic tail signal transduction motif.	Tetradecanoylphorbol Acetate	14-17	programmed cell death 1	Homo sapiens	82-87
9075730-3	1997	GnRH-a and TPA apparently activated mainly the MAPK isoform ERK1, as revealed by Mono-Q fast protein liquid chromatography followed by Western blotting as well as by gel kinase assay.	Tetradecanoylphorbol Acetate	11-14	mitogen-activated protein kinase 3	Mus musculus	60-64
9176109-6	1997	Using immunocytochemistry, PKC theta, delta and eta had distinct patterns of redistribution following activation by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	116-141	endothelin receptor type A	Homo sapiens	33-36
9176109-6	1997	Using immunocytochemistry, PKC theta, delta and eta had distinct patterns of redistribution following activation by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	143-146	endothelin receptor type A	Homo sapiens	33-36
9150350-4	1997	Stimulation with TPA or LPS induced changes in morphology and gene expression, especially an increase in the level of the differentiation marker CD14 and the production of monocyte-related cytokines.	Tetradecanoylphorbol Acetate	17-20	CD14 molecule	Homo sapiens	145-149
9106470-4	1997	In contrast, the PMA-inhibitory effect on GnRH cytoplasmic mRNA levels was significantly reduced or inhibited in the presence of cycloheximide or RNA synthesis inhibitors given within 4 h of PMA, suggesting a protein/RNA synthesis-dependent mechanism for the regulation of GnRH mRNA levels by PMA.	Tetradecanoylphorbol Acetate	17-20	gonadotropin releasing hormone 1	Homo sapiens	42-46
9106470-4	1997	In contrast, the PMA-inhibitory effect on GnRH cytoplasmic mRNA levels was significantly reduced or inhibited in the presence of cycloheximide or RNA synthesis inhibitors given within 4 h of PMA, suggesting a protein/RNA synthesis-dependent mechanism for the regulation of GnRH mRNA levels by PMA.	Tetradecanoylphorbol Acetate	17-20	gonadotropin releasing hormone 1	Homo sapiens	273-277
9045715-7	1997	The activity of the recombinant enzyme regarding substrate phosphorylation, autophosphorylation, and dependence on activation by 12-O-tetradecanoylphorbol-13-acetate as well as the Km values for two substrates are comparable to those of recombinant PKCdelta expressed in baculovirus-infected insect cells.	Tetradecanoylphorbol Acetate	129-165	protein kinase C, delta	Rattus norvegicus	249-257
9067545-4	1997	Compared with the parental and vector-transfected (gpt) control cells, MnSOD-overexpressing cells had a slower growth rate and their ability to form colonies in soft agar was significantly decreased in response to 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	214-250	superoxide dismutase 2	Homo sapiens	71-76
9067545-4	1997	Compared with the parental and vector-transfected (gpt) control cells, MnSOD-overexpressing cells had a slower growth rate and their ability to form colonies in soft agar was significantly decreased in response to 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	252-255	superoxide dismutase 2	Homo sapiens	71-76
9067545-6	1997	Overexpression of MnSOD led to a significant decrease in c-jun and c-fos expression in response to treatment with TPA or the oxidant promoter superoxide.	Tetradecanoylphorbol Acetate	114-117	superoxide dismutase 2	Homo sapiens	18-23
9041261-5	1997	By contrast, ionomycin and phorbol-12-myristate 13-acetate increased mucin secretion by 292% +/- 48% and 134% +/- 19% over basal level, respectively.	Tetradecanoylphorbol Acetate	27-58	LOC100508689	Homo sapiens	69-74
9040943-3	1997	In this study, we investigated the physiological relevance of MDR1 gene regulation by NF-IL6 in response to PMA (phorbol 12-myristate 13-acetate)-induced differentiation.	Tetradecanoylphorbol Acetate	108-111	CCAAT enhancer binding protein beta	Homo sapiens	86-92
9040943-3	1997	In this study, we investigated the physiological relevance of MDR1 gene regulation by NF-IL6 in response to PMA (phorbol 12-myristate 13-acetate)-induced differentiation.	Tetradecanoylphorbol Acetate	113-144	CCAAT enhancer binding protein beta	Homo sapiens	86-92
9040944-3	1997	The subcellular localization of PKCs is identical in wt and resistant cells with the exception of PKC beta 2, which no longer colocalizes with microtubules in the TPA-resistant cell lines.	Tetradecanoylphorbol Acetate	163-166	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	102-108
9040945-1	1997	Phorbol ester-induced beta 2-integrin transport to the cell surface is defective in cloned 12-O-tetradecanoylphorbol-13-acetate (TPA)-resistant U937 cell variants.	Tetradecanoylphorbol Acetate	91-127	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	22-28
9040945-1	1997	Phorbol ester-induced beta 2-integrin transport to the cell surface is defective in cloned 12-O-tetradecanoylphorbol-13-acetate (TPA)-resistant U937 cell variants.	Tetradecanoylphorbol Acetate	129-132	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	22-28
9040945-4	1997	Diminished protein kinase C (PKC) beta 2 association with microtubules correlated with the loss of heat-soluble microtubule-associated PKC-binding proteins and the loss of TPA-inducible reorganization of the microtubule cytoskeleton in the resistant U937 variants.	Tetradecanoylphorbol Acetate	172-175	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	34-40
9040945-8	1997	Results from these studies suggest that TPA-induced microtubule reorganization is a prerequisite for integrin vesicle translocation in U937 cells and that vesicle translocation to the plasma membrane may be a prerequisite for the transcriptional activation of cd11b and cd11c integrin genes in the early stages of monocyte differentiation.	Tetradecanoylphorbol Acetate	40-43	integrin subunit alpha X	Homo sapiens	270-275
9052740-6	1997	The apoptotic response to the anti-CD40 mAb M3, but not M2, was enhanced by PMA and dibutyryl cyclic adenosine monophosphate (db-cAMP), which also increased mRNA levels and surface expression of CD40/CD95.	Tetradecanoylphorbol Acetate	76-79	CD40 molecule	Homo sapiens	35-39
9045910-6	1997	Pre-incubation of CD4+ T lymphocytes in the presence of anti-CD4 mAb or gp160 inhibits the activation of JNK in response to phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	124-155	glutamyl aminopeptidase	Homo sapiens	72-77
9143936-3	1997	LoVo-Dx cells, became resistant to LAK cells and ATP after 48 h pretreatment with Phorbol 12-Myristate-13-Acetate (PMA), while 48 h pretreatment with verapamil in parallel sensitized LoVo cells to LAK cells and to ATP as well.	Tetradecanoylphorbol Acetate	115-118	ADP ribosylation factor like GTPase 4C	Homo sapiens	35-38
8999958-3	1997	Ceramide-induced apoptosis was reported to be blocked by 12-O-tetradecanoylphorbol 13-acetate, a protein kinase C (PKC) activator, but its mechanism remained unclear.	Tetradecanoylphorbol Acetate	57-93	protein kinase C delta	Homo sapiens	115-118
8995230-4	1997	TPA treatment of L epsilon delta, cells that overexpressed the PKC-epsilon delta chimera, induced a dramatically increased cell volume, surface adherence, surface expression of Mac-1 and Mac-3, lysozyme production, and phagocytosis.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, epsilon	Mus musculus	63-74
8995230-7	1997	A PKC inhibitor directed toward the catalytic domain of PKC, GF109203X, and a selective inhibitor of PKC-delta, Rottlerin, blocked the TPA-induced differentiation of PKC-epsilon delta-overexpressing 32D cells.	Tetradecanoylphorbol Acetate	135-138	protein kinase C, epsilon	Mus musculus	166-177
8977403-9	1997	In contrast, phorbol 12-myristate 13-acetate inhibited basal as well as hCG- and 8-bromo-cAMP-induced FP receptor mRNA expression and binding of the radiolabeled ligand.	Tetradecanoylphorbol Acetate	13-44	hypertrichosis 2 (generalised, congenital)	Homo sapiens	72-75
9218534-6	1997	Since the co-expression with a dominant negative c-Fos abolished the responsiveness to TPA, we conclude that activated transcription of the DRA gene depends on interactions between the X2 box and NF-X2, which contains c-Fos.	Tetradecanoylphorbol Acetate	87-90	nuclear transcription factor, X-box binding 1	Homo sapiens	185-201
9591190-4	1997	It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU).	Tetradecanoylphorbol Acetate	16-52	jun proto-oncogene	Mus musculus	217-222
9591190-4	1997	It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU).	Tetradecanoylphorbol Acetate	54-57	jun proto-oncogene	Mus musculus	217-222
8978751-8	1997	Selective down-regulation of PKC subtypes by prolonged exposure to phorbol 12,13-dibutyrate (100 nM) attenuated the TPA-induced enhancement of NA release and the translocation of MARCKS over an interval similar to that of down-regulation of PKC-alpha (but not -epsilon or -zeta).	Tetradecanoylphorbol Acetate	116-119	myristoylated alanine rich protein kinase C substrate	Homo sapiens	179-185
8978751-9	1997	Thus, we have demonstrated a strong correlation between the translocation of MARCKS and the enhancement of NA release from SH-SY5Y cells due to the TPA-induced activation of PKC-alpha.	Tetradecanoylphorbol Acetate	148-151	myristoylated alanine rich protein kinase C substrate	Homo sapiens	77-83
9022811-3	1997	AP-1 DNA binding to the jun 12-O-tetradecanoylphorbol-13-acetate-response element (TGACATCA) as determined by gel shift analysis was strongly induced by OA (100 ng/mL) at 6 and 12 h. Preincubation of nuclear extracts with anti-c-jun antibody demonstrated that c-jun was a major component of the DNA-bound AP-1 complex induced by OA in 308 cells.	Tetradecanoylphorbol Acetate	28-64	jun proto-oncogene	Mus musculus	0-4
9022811-3	1997	AP-1 DNA binding to the jun 12-O-tetradecanoylphorbol-13-acetate-response element (TGACATCA) as determined by gel shift analysis was strongly induced by OA (100 ng/mL) at 6 and 12 h. Preincubation of nuclear extracts with anti-c-jun antibody demonstrated that c-jun was a major component of the DNA-bound AP-1 complex induced by OA in 308 cells.	Tetradecanoylphorbol Acetate	28-64	jun proto-oncogene	Mus musculus	227-232
9022811-3	1997	AP-1 DNA binding to the jun 12-O-tetradecanoylphorbol-13-acetate-response element (TGACATCA) as determined by gel shift analysis was strongly induced by OA (100 ng/mL) at 6 and 12 h. Preincubation of nuclear extracts with anti-c-jun antibody demonstrated that c-jun was a major component of the DNA-bound AP-1 complex induced by OA in 308 cells.	Tetradecanoylphorbol Acetate	28-64	jun proto-oncogene	Mus musculus	260-265
9022811-3	1997	AP-1 DNA binding to the jun 12-O-tetradecanoylphorbol-13-acetate-response element (TGACATCA) as determined by gel shift analysis was strongly induced by OA (100 ng/mL) at 6 and 12 h. Preincubation of nuclear extracts with anti-c-jun antibody demonstrated that c-jun was a major component of the DNA-bound AP-1 complex induced by OA in 308 cells.	Tetradecanoylphorbol Acetate	28-64	jun proto-oncogene	Mus musculus	305-309
8988173-6	1997	Mutagenesis of an AP2 DNA-binding site within a p21 promoter-luciferase reporter inhibited its activation by either AP2 transfection or TPA stimulation.	Tetradecanoylphorbol Acetate	136-139	transcription factor AP-2, alpha	Mus musculus	18-21
11173634-2	1997	Previously, we have shown, that PMA pretreatment reduced etoposide-(ETO) but enhanced staurosporine- (STA) -induced apoptosis in HT58 cells.	Tetradecanoylphorbol Acetate	32-35	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	68-71
11173634-4	1997	The sensitivity of HT58 cells to ETO- or STA-induced apoptosis is influenced diversely with PMA pre- or posttreatment.	Tetradecanoylphorbol Acetate	92-95	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	33-37
9633822-3	1997	FGF-2 and TPA respectively caused 2.5- and 3.0-fold reductions in antisense-FGF-2 transfectant doubling-time.	Tetradecanoylphorbol Acetate	10-13	fibroblast growth factor 2	Rattus norvegicus	76-81
9633822-4	1997	Culture of antisense-FGF-2 transfectants in medium containing both FGF-2 and TPA further reduced their doubling time; however, this effect was not statistically different from that achieved by TPA treatment alone.	Tetradecanoylphorbol Acetate	77-80	fibroblast growth factor 2	Rattus norvegicus	21-26
8955178-5	1996	IL-7R -/- T cells were also significantly less responsive to alloantigen as well as to receptor-independent stimuli such as PMA and ionomycin.	Tetradecanoylphorbol Acetate	124-127	interleukin 7 receptor	Mus musculus	0-5
8973627-4	1996	The CD4+CD7- subpopulation was found to secrete significantly higher levels of IL-5 compared with the CD4+CD7- subset upon stimulation with ionomycin/phorbol myristate acetate (PMA) plus anti-CD28 MoAbs.	Tetradecanoylphorbol Acetate	150-175	interleukin 5	Homo sapiens	79-83
8973627-4	1996	The CD4+CD7- subpopulation was found to secrete significantly higher levels of IL-5 compared with the CD4+CD7- subset upon stimulation with ionomycin/phorbol myristate acetate (PMA) plus anti-CD28 MoAbs.	Tetradecanoylphorbol Acetate	177-180	interleukin 5	Homo sapiens	79-83
8989917-6	1996	Suppression of TPA (100 ng/mL)-induced c-jun and c-fos gene expression was also observed in the mouse fibroblast cells pretreated with crocetin (30, 60, and 120 microM).	Tetradecanoylphorbol Acetate	15-18	jun proto-oncogene	Mus musculus	39-44
8895766-9	1996	A protein kinase C activator, phorbol 12-myristate 13-acetate, increased the adhesion of PC-3 cells to PAC-1, a mAb specific to the high-affinity state of alphaIIb(beta)3, by more than 80-fold.	Tetradecanoylphorbol Acetate	30-61	dual specificity phosphatase 2	Homo sapiens	103-108
8930166-2	1996	The following agents inhibited phorbol 12-myristate 13-acetate-stimulated O2- generation significantly in the all-trans retinoic acid-treated HL-60 cells (expressed as percentage of control, P &lt; .05): 1) PKC inhibitors: staurosporine (100 nM, 3 +/- 1%); Ro 31-8220 (1 microM, 3 +/- 2%); sphingosine (100 microM, 15 +/- 7%); 2) PSP 1 and 2a inhibitors, okadaic acid (10 microM, 35 +/- 1%); calyculin A (10 microM, 73 +/- 1%); 3) MAPK inhibitor: SB-203580 (100 microM, 62 +/- 1%); 4) PTP inhibitors: phenylarsine oxide (1 microM, 12 +/- 9%); diamide (1 mM, 21 +/- 11%); and 5) secretory phospholipase A2 inhibitors: manoalide (1 microM, 24 +/- 10%); scalaradial (1 microM, 11 +/- 4%).	Tetradecanoylphorbol Acetate	31-62	protein tyrosine phosphatase receptor type U	Homo sapiens	485-488
8912706-0	1996	Phorbol 12-myristate 13-acetate inhibits epidermal growth factor signalling in human keratinocytes, leading to decreased ornithine decarboxylase activity.	Tetradecanoylphorbol Acetate	0-31	ornithine decarboxylase 1	Homo sapiens	121-144
8912706-7	1996	In this report, 10(-10) M-10(-7) M PMA induced ODC mRNA and enzyme synthesis at 7 h, but did not significantly induce ODC activity and inhibited the EGF induction of ODC activity.	Tetradecanoylphorbol Acetate	35-38	ornithine decarboxylase 1	Homo sapiens	47-50
8912706-12	1996	Additionally, PMA inhibited the induction of ODC by EGF through decreased EGF binding, possibly mediated by PKC activation.	Tetradecanoylphorbol Acetate	14-17	ornithine decarboxylase 1	Homo sapiens	45-48
8823487-8	1996	This study indicates that the comeasurement of CA 15-3 with TPA or MCA with TPA is justifiable in monitoring breast cancer patients postoperatively.	Tetradecanoylphorbol Acetate	60-63	mucin 1, cell surface associated	Homo sapiens	47-54
8823487-8	1996	This study indicates that the comeasurement of CA 15-3 with TPA or MCA with TPA is justifiable in monitoring breast cancer patients postoperatively.	Tetradecanoylphorbol Acetate	76-79	mucin 1, cell surface associated	Homo sapiens	47-54
8828483-7	1996	Phorbol myristate acetate, an activator of protein kinase C, mimicked the effects of bFGF and TGF alpha.	Tetradecanoylphorbol Acetate	0-25	fibroblast growth factor 2	Rattus norvegicus	85-89
8828483-8	1996	Interestingly, long term (24-h) pretreatment with phorbol myristate acetate resulted in a severe loss of responsiveness to bFGF or TGF alpha.	Tetradecanoylphorbol Acetate	50-75	fibroblast growth factor 2	Rattus norvegicus	123-127
7774647-3	1995	Phorbol 12-myristate 13-acetate, A23187 and N6, 2"-O-dibutyryl-adenosine 3":5"-cyclic monophosphate co-stimulation of EL4 cells transfected with the human IL-5/luciferase reporter gene construct resulted in maximal induction of the luciferase gene.	Tetradecanoylphorbol Acetate	0-31	interleukin 5	Homo sapiens	155-159
7730337-7	1995	The expression of a Ng/RC3-luciferase fusion construct (-1508/+256) in transfected 293 cells was stimulated by phorbol 12-myristate 13-acetate (PMA), but not by cAMP, arachidonic acid, vitamin D, retinoic acid, or thyroxines T3 and T4.	Tetradecanoylphorbol Acetate	111-142	neurogranin	Homo sapiens	23-26
7730337-7	1995	The expression of a Ng/RC3-luciferase fusion construct (-1508/+256) in transfected 293 cells was stimulated by phorbol 12-myristate 13-acetate (PMA), but not by cAMP, arachidonic acid, vitamin D, retinoic acid, or thyroxines T3 and T4.	Tetradecanoylphorbol Acetate	144-147	neurogranin	Homo sapiens	23-26
7774812-7	1995	Whereas T beta RI levels remained relatively constant, T beta RII expression was strongly induced in TPA-treated skins, prior to the induction of the growth inhibitory response to TGF-beta 1, and its level of expression correlated with growth sensitivity to TGF-beta 1 in vivo and in vitro.	Tetradecanoylphorbol Acetate	101-104	transforming growth factor, beta 1	Mus musculus	180-190
7774812-7	1995	Whereas T beta RI levels remained relatively constant, T beta RII expression was strongly induced in TPA-treated skins, prior to the induction of the growth inhibitory response to TGF-beta 1, and its level of expression correlated with growth sensitivity to TGF-beta 1 in vivo and in vitro.	Tetradecanoylphorbol Acetate	101-104	transforming growth factor, beta 1	Mus musculus	258-268
7739574-3	1995	We investigated the regulation of the CD11c gene in the promyeloblastic leukemic cell line, HL60, following differentiation along the monocytic pathway with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	157-188	integrin subunit alpha X	Homo sapiens	38-43
7739574-3	1995	We investigated the regulation of the CD11c gene in the promyeloblastic leukemic cell line, HL60, following differentiation along the monocytic pathway with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	190-193	integrin subunit alpha X	Homo sapiens	38-43
7876543-1	1995	We have shown previously that a 52-kDa phosphoprotein (p52) co-precipitated with Ig receptor (IgR)-associated MB-1 protein was inducibly phosphorylated by the stimulation with 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	176-213	immunoglobulin (CD79A) binding protein 1	Mus musculus	55-58
7534073-5	1995	However, when protein kinase C (PKC) was either inhibited by the PKC inhibitor GF 109203X or depleted by a prolonged TPA treatment, the stimulation of MBP phosphorylation by EGF was strongly inhibited.	Tetradecanoylphorbol Acetate	117-120	myelin basic protein	Homo sapiens	151-154
7532590-5	1995	However, a strong phosphorylation of the CD18-chain by preexposure to phorbol myristate acetate (PMA) coincided with an abolishment of both the beta 2-integrin-induced Ca2+ signal and the protein tyrosine phosphorylations.	Tetradecanoylphorbol Acetate	70-95	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	144-150
7776154-4	1995	The PA produced by Gin-1 cells was determined to be urokinase PA (uPA), as preincubation of Gin-1 conditioned medium with anti-uPA antiserum completely inhibited the PA activity while that with anti-tPA antiserum had no inhibitory effect.	Tetradecanoylphorbol Acetate	199-202	gypsy retrotransposon integrase 1	Homo sapiens	19-24
7854777-0	1995	Humulon, a bitter in the hop, inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.	Tetradecanoylphorbol Acetate	58-94	tetratricopeptide repeat domain 26	Mus musculus	25-28
7830075-1	1995	Correlation between translocation and down-regulation of conventional protein kinase C alpha (cPKC alpha) and new PKC delta (nPKC delta) induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) at different time courses (5 min, 30 min, 1 h, 3 h, 6 h, 10 h, 17 h, and 24 h) was studied in C6 glioma cells.	Tetradecanoylphorbol Acetate	148-184	protein kinase C delta	Homo sapiens	114-123
7830075-1	1995	Correlation between translocation and down-regulation of conventional protein kinase C alpha (cPKC alpha) and new PKC delta (nPKC delta) induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) at different time courses (5 min, 30 min, 1 h, 3 h, 6 h, 10 h, 17 h, and 24 h) was studied in C6 glioma cells.	Tetradecanoylphorbol Acetate	148-184	protein kinase C delta	Homo sapiens	125-135
7830075-1	1995	Correlation between translocation and down-regulation of conventional protein kinase C alpha (cPKC alpha) and new PKC delta (nPKC delta) induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) at different time courses (5 min, 30 min, 1 h, 3 h, 6 h, 10 h, 17 h, and 24 h) was studied in C6 glioma cells.	Tetradecanoylphorbol Acetate	186-189	protein kinase C delta	Homo sapiens	114-123
7830075-1	1995	Correlation between translocation and down-regulation of conventional protein kinase C alpha (cPKC alpha) and new PKC delta (nPKC delta) induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) at different time courses (5 min, 30 min, 1 h, 3 h, 6 h, 10 h, 17 h, and 24 h) was studied in C6 glioma cells.	Tetradecanoylphorbol Acetate	186-189	protein kinase C delta	Homo sapiens	125-135
7830075-2	1995	From the dose-dependent translocations of these two isoforms by 10-min treatment with TPA (1, 3, 10, 30, 100, 300, and 1,000 nM), we found that cPKC alpha was translocated by 3-1,000 nM and nPKC delta was translocated by 10-1,000 nM TPA.	Tetradecanoylphorbol Acetate	86-89	protein kinase C delta	Homo sapiens	190-200
7869773-4	1995	Stimulation with phorbol 12-myristate 13-acetate (PMA) dramatically increased the expression of megakaryocyte-related markers such as HPL-3, J15, Pit-1, Y2/51 and AN51 in MEG-A2 cells.	Tetradecanoylphorbol Acetate	17-48	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	171-174
7695161-2	1995	Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes.	Tetradecanoylphorbol Acetate	29-54	integrin subunit alpha L	Homo sapiens	131-136
7695161-2	1995	Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes.	Tetradecanoylphorbol Acetate	29-54	integrin subunit alpha X	Homo sapiens	145-150
7695161-2	1995	Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes.	Tetradecanoylphorbol Acetate	56-59	integrin subunit alpha L	Homo sapiens	131-136
7695161-2	1995	Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes.	Tetradecanoylphorbol Acetate	56-59	integrin subunit alpha X	Homo sapiens	145-150
7695161-8	1995	The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 also showed inhibitory effects on the increase in intracellular fluorescence intensity of the endothelial cells exposed to PMA-stimulated leukocytes.	Tetradecanoylphorbol Acetate	188-191	integrin subunit alpha L	Homo sapiens	34-39
7704836-1	1995	Expression of CD18 on bovine neutrophils in response to stimulation by zymosan activated serum (ZAS) and phorbol myristate acetate (PMA) and the effects of monoclonal antibodies (MAB) recognizing CD18 or bovine neutrophil surface antigens (S2G8 and S5F8G10) on adherence, chemotactic responses and phagocytosis of bovine neutrophils were evaluated.	Tetradecanoylphorbol Acetate	105-130	integrin subunit beta 2	Bos taurus	14-18
8777434-5	1995	All trans-retinoic acid (RA) abolished the transformation of the 43C line and TPA-treated RELcJ1 cells, suggesting that RA could decrease AP1 activity in these cells despite c-fos or c-jun overexpression.	Tetradecanoylphorbol Acetate	78-81	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	138-141
7889145-10	1995	Treatment with phorbol 12-myristate 13-acetate, a PKC activator, increased MARCKS phosphorylation approximately 4-fold.	Tetradecanoylphorbol Acetate	15-46	myristoylated alanine rich protein kinase C substrate	Homo sapiens	75-81
7718506-6	1995	It has to be noted that perturbation of the same 150 kDa surface molecule with BB18 mAb exerts no effect on CD2 and CD3 induced proliferations, while inducing a strong lymphocyte proliferation in the presence of submitogenic concentrations of phorbol myristate acetate.	Tetradecanoylphorbol Acetate	243-268	semaphorin 4D	Homo sapiens	79-83
7537746-10	1995	However, compared to angiotensin II stimulation, a smaller, delayed increase in paxillin tyrosine phosphorylation was observed following direct protein kinase C activation by the phorbol ester phorbol 12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	193-224	paxillin	Rattus norvegicus	80-88
7796933-6	1995	Consistently, ionomycin plus low doses of TPA solely reproduced the potent effect of TRH on c-fos transcripts.	Tetradecanoylphorbol Acetate	42-45	thyrotropin releasing hormone	Rattus norvegicus	85-88
7796933-7	1995	Data collected from TRH and TPA down-regulated cells indicated that TRH probably recruits TPA-dependent PKC isoforms for stimulating c-fos but not jun B transcripts.	Tetradecanoylphorbol Acetate	28-31	thyrotropin releasing hormone	Rattus norvegicus	68-71
7796933-7	1995	Data collected from TRH and TPA down-regulated cells indicated that TRH probably recruits TPA-dependent PKC isoforms for stimulating c-fos but not jun B transcripts.	Tetradecanoylphorbol Acetate	90-93	thyrotropin releasing hormone	Rattus norvegicus	68-71
7802642-2	1994	By primer extension analysis to discriminate two transcripts, we found that the levels of PAFR transcript 1 (leukocyte-type), but not PAFR transcript 2 (tissue-type), are upregulated by PAF as well as by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the human stomach cancer cell line (JR-St cells) which expresses both functional PAFR transcript 1 and PAFR transcript 2 endogenously.	Tetradecanoylphorbol Acetate	204-240	platelet activating factor receptor	Homo sapiens	90-94
7802642-2	1994	By primer extension analysis to discriminate two transcripts, we found that the levels of PAFR transcript 1 (leukocyte-type), but not PAFR transcript 2 (tissue-type), are upregulated by PAF as well as by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the human stomach cancer cell line (JR-St cells) which expresses both functional PAFR transcript 1 and PAFR transcript 2 endogenously.	Tetradecanoylphorbol Acetate	242-245	platelet activating factor receptor	Homo sapiens	90-94
7527042-6	1994	The activation of Raf-1 kinase and MAP kinase is inhibited by phorbol 12-myristate 13-acetate pretreatment in the presence of calphostin C or H-7.	Tetradecanoylphorbol Acetate	62-93	Raf-1 proto-oncogene, serine/threonine kinase	Canis lupus familiaris	18-23
7528111-7	1994	In the papillary dermis, however, RPA was more potent than TPA in inducing vascularization and tenascin expression.	Tetradecanoylphorbol Acetate	59-62	tenascin C	Mus musculus	95-103
8001237-4	1994	Fifteen minutes following topical treatment with a tumor promoting dose of TPA (3.4 nmol), the activities of PKC beta and PKC gamma decreased in the epidermal cytosol to 30% and 50% of control values, respectively, while these activities were increased in the epidermal particulate fraction by approximately 50%.	Tetradecanoylphorbol Acetate	75-78	protein kinase C, beta	Mus musculus	109-117
8001237-7	1994	Immunoblotting analyses of PKC isozyme protein levels after TPA treatment followed the changes in activity for cytosolic PKC alpha, PKC beta and PKC gamma.	Tetradecanoylphorbol Acetate	60-63	protein kinase C, beta	Mus musculus	132-140
7704445-4	1994	Protein kinase C (PKC) depletion induced by a pretreatment with 1 microM PMA for 24 h abolished spontaneous Ca2+ transients and the action of GnRH on [Ca2+]i and Ca2+ channels.	Tetradecanoylphorbol Acetate	73-76	gonadotropin releasing hormone 1	Homo sapiens	142-146
7954373-0	1994	Curcumin inhibits TPA induced expression of c-fos, c-jun and c-myc proto-oncogenes messenger RNAs in mouse skin.	Tetradecanoylphorbol Acetate	18-21	jun proto-oncogene	Mus musculus	51-56
7954373-7	1994	In the present studies, we investigated the effect of curcumin on the expression of c-fos, c-jun and c-myc oncogenes in TPA-treated mouse skin in CD-1 mice.	Tetradecanoylphorbol Acetate	120-123	jun proto-oncogene	Mus musculus	91-96
7954373-8	1994	A 30-nmol dose of TPA increased the levels of mRNAs for c-fos, c-jun and c-myc oncogenes by 2-3-fold compared with control.	Tetradecanoylphorbol Acetate	18-21	jun proto-oncogene	Mus musculus	63-68
7954373-11	1994	A dose of 10 mumol of curcumin was found to inhibit 90% TPA-induced expression of c-fos and c-jun, and 60% of c-myc.	Tetradecanoylphorbol Acetate	56-59	jun proto-oncogene	Mus musculus	92-97
7963537-5	1994	Both the direct increase in intracellular Ca2+ with calcium ionophore and the activation of protein kinase C (PKC) with PMA induced tyrosine phosphorylation of paxillin.	Tetradecanoylphorbol Acetate	120-123	paxillin	Rattus norvegicus	160-168
7525098-1	1994	The type I keratin K13, normally restricted to suprabasal cells of internal stratified epithelia, is aberrantly expressed in 7,12-dimethylbenz[a]anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate-induced murine epidermal tumors and constitutes an early marker of malignant progression.	Tetradecanoylphorbol Acetate	163-200	keratin 13	Mus musculus	19-22
7531490-2	1994	Although p56lck is thought to be a specific T-cell marker, we found that LSTRA cells can be induced to differentiate towards macrophages or granulocytes by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate or the cyclic nucleotide analogue, dibutyryl cAMP, respectively.	Tetradecanoylphorbol Acetate	175-211	lymphocyte protein tyrosine kinase	Mus musculus	9-15
7531490-7	1994	Thus, while 12-O-tetradecanoylphorbol-13-acetate treatment caused the cells to produce higher molecular weight forms of p56lck, dibutyryl cAMP treatment resulted in increased expression of total p56lck mRNA as well as the more mature type II p56lck mRNA transcript.	Tetradecanoylphorbol Acetate	12-48	lymphocyte protein tyrosine kinase	Mus musculus	120-126
7936644-0	1994	Signalling from TPA to MAP kinase requires protein kinase C, raf and MEK: reconstitution of the signalling pathway in vitro.	Tetradecanoylphorbol Acetate	16-19	zinc fingers and homeoboxes 2	Homo sapiens	61-64
7936644-4	1994	Using recombinant proteins and in vitro phosphorylation reactions we identified the components in the signal transduction pathway from TPA to MAPkinase and we show that the activation of MAPkinase by TPA requires the presence of protein kinase C, c-raf and the MAPkinase activator MEK.	Tetradecanoylphorbol Acetate	135-138	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	247-252
7936644-4	1994	Using recombinant proteins and in vitro phosphorylation reactions we identified the components in the signal transduction pathway from TPA to MAPkinase and we show that the activation of MAPkinase by TPA requires the presence of protein kinase C, c-raf and the MAPkinase activator MEK.	Tetradecanoylphorbol Acetate	200-203	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	247-252
7524087-3	1994	The level of constitutive expression attained in the transgenic mice exceeded the peak level of ICAM-1 expression induced on nontransgenic mouse keratinocytes in vitro by optimal combinations of interferon gamma and tumor necrosis factor alpha or in vivo by proinflammatory stimuli such as phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	290-321	intercellular adhesion molecule 1	Mus musculus	96-102
7889109-4	1994	When phorbol 12-myristate 13-acetate (PMA) was added to cultures, hCG secretion was increased dose-dependently, but cell proliferation and 3H-thymidine uptake were not affected.	Tetradecanoylphorbol Acetate	5-36	chorionic gonadotropin subunit beta 5	Homo sapiens	66-69
7889109-4	1994	When phorbol 12-myristate 13-acetate (PMA) was added to cultures, hCG secretion was increased dose-dependently, but cell proliferation and 3H-thymidine uptake were not affected.	Tetradecanoylphorbol Acetate	38-41	chorionic gonadotropin subunit beta 5	Homo sapiens	66-69
7523138-2	1994	While the biochemical signaling events following CD28 stimulation are still poorly defined, monoclonal antibodies (mAb) directed against CD28 have been shown to transduce a variety of early signals that are different in the presence of cross-linking antibody or the presence of phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	278-309	CD28 molecule	Homo sapiens	137-141
7523138-2	1994	While the biochemical signaling events following CD28 stimulation are still poorly defined, monoclonal antibodies (mAb) directed against CD28 have been shown to transduce a variety of early signals that are different in the presence of cross-linking antibody or the presence of phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	311-314	CD28 molecule	Homo sapiens	137-141
8816498-9	1996	Finally, disruption of the Raf-1-MEK-MAPK signalling pathway by GA prevents both the PMA-induced proliferative response and PMA-induced activation of a MAPK-sensitive nuclear transcription factor.	Tetradecanoylphorbol Acetate	85-88	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	27-32
8816498-9	1996	Finally, disruption of the Raf-1-MEK-MAPK signalling pathway by GA prevents both the PMA-induced proliferative response and PMA-induced activation of a MAPK-sensitive nuclear transcription factor.	Tetradecanoylphorbol Acetate	85-88	midkine	Mus musculus	33-36
8816498-9	1996	Finally, disruption of the Raf-1-MEK-MAPK signalling pathway by GA prevents both the PMA-induced proliferative response and PMA-induced activation of a MAPK-sensitive nuclear transcription factor.	Tetradecanoylphorbol Acetate	124-127	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	27-32
8816498-9	1996	Finally, disruption of the Raf-1-MEK-MAPK signalling pathway by GA prevents both the PMA-induced proliferative response and PMA-induced activation of a MAPK-sensitive nuclear transcription factor.	Tetradecanoylphorbol Acetate	124-127	midkine	Mus musculus	33-36
8863815-1	1996	Gastrin-releasing peptide and other bombesin-like peptides stimulate secretion, cell proliferation, and smooth muscle contraction via a family of G protein-coupled receptors that activate phospholipase C. Second messenger formation by one of these receptors, called BR1, is rapidly desensitized after treatment of cells with either agonists or the protein kinase C activator 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	375-411	chemokine (C-X-C motif) ligand 11	Mus musculus	266-269
8863815-1	1996	Gastrin-releasing peptide and other bombesin-like peptides stimulate secretion, cell proliferation, and smooth muscle contraction via a family of G protein-coupled receptors that activate phospholipase C. Second messenger formation by one of these receptors, called BR1, is rapidly desensitized after treatment of cells with either agonists or the protein kinase C activator 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	413-416	chemokine (C-X-C motif) ligand 11	Mus musculus	266-269
8863815-12	1996	The differential specificity of the antibody for various phosphorylated forms of BR1 demonstrates that agonist-induced and TPA-induced phosphorylations of the receptor occur at distinct sites.	Tetradecanoylphorbol Acetate	123-126	chemokine (C-X-C motif) ligand 11	Mus musculus	81-84
7523141-4	1994	We demonstrate that both the TcR+ and TcR- clones were able to express the Fas ligand after stimulation with phorbol 12-myristate 13-acetate (PMA)/ionomycin, and that TcR engagement of the KB5.C20 clone by means of antigen-bearing cells or of its anticlonotypic mAb (Desire-1), which leads to Ca(2+)-dependent, presumably perforin-based, cytotoxicity, was also able to induce Fas-based cytotoxicity.	Tetradecanoylphorbol Acetate	109-140	Fas ligand	Rattus norvegicus	75-85
7523141-4	1994	We demonstrate that both the TcR+ and TcR- clones were able to express the Fas ligand after stimulation with phorbol 12-myristate 13-acetate (PMA)/ionomycin, and that TcR engagement of the KB5.C20 clone by means of antigen-bearing cells or of its anticlonotypic mAb (Desire-1), which leads to Ca(2+)-dependent, presumably perforin-based, cytotoxicity, was also able to induce Fas-based cytotoxicity.	Tetradecanoylphorbol Acetate	142-145	Fas ligand	Rattus norvegicus	75-85
10411901-7	1999	Induction of the TGFbeta1 transgene expression also caused epidermal resistance to phorbol 12-myristate 13-acetate-induced hyperplasia, with a reduction in both epidermal thickness and BrdUrd labeling compared with those in controls.	Tetradecanoylphorbol Acetate	83-114	transforming growth factor, beta 1	Mus musculus	17-25
7835952-5	1994	In four of five patients studied, phorbol myristate acetate (PMA) stimulation of PBMC induced them to produce more IL-5 mRNA than four healthy subjects.	Tetradecanoylphorbol Acetate	34-59	interleukin 5	Homo sapiens	115-119
7835952-5	1994	In four of five patients studied, phorbol myristate acetate (PMA) stimulation of PBMC induced them to produce more IL-5 mRNA than four healthy subjects.	Tetradecanoylphorbol Acetate	61-64	interleukin 5	Homo sapiens	115-119
8891115-6	1996	Anti-PKC beta antibody significantly inhibited PMA-induced HIV-1 production, whereas antibodies against PKC alpha and gamma had no significant effect.	Tetradecanoylphorbol Acetate	47-50	protein kinase C beta	Homo sapiens	5-13
8891115-7	1996	Furthermore, anti-PKC beta antibody inhibited PMA-induced activation of NF-kappa B and HIV-1 LTR.	Tetradecanoylphorbol Acetate	46-49	protein kinase C beta	Homo sapiens	18-26
7522246-6	1994	The culture supernatants of HK cells had costimulatory activity on the proliferation of anti-mu- or anti-CD40-activated B cells, and the activity dramatically increased after 12-O-tetradecanoylphorbol 13-acetate stimulation.	Tetradecanoylphorbol Acetate	175-211	CD40 molecule	Homo sapiens	105-109
10567948-8	1999	In RT-PCR experiments, tissue type PA (tPA) mRNA levels in both aged hGF and rGF were higher than in young cells, whereas plasminogen activator inhibitor 1 (PAI-1) mRNA remained unchanged and urotype PA (uPA) mRNA was not detected.	Tetradecanoylphorbol Acetate	39-42	hepatocyte growth factor	Homo sapiens	69-72
7935389-1	1994	The cytoplasmic Raf-1 kinase is essential for mitogenic signalling by growth factors, which couple to tyrosine kinases, and by tumor-promoting phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate, which activate protein kinase C (PKC).	Tetradecanoylphorbol Acetate	166-202	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	16-21
8836045-4	1996	Investigation into the intracellular mechanisms of PACAP action revealed that the increase in L-channel currents was blocked by calphostin C and bisindolylmaleimide IV [protein kinase C (PKC) inhibitors] and mimicked by 4 beta-phorbol 12-myristate 13-acetate (PMA), an activator of PKC.	Tetradecanoylphorbol Acetate	260-263	adenylate cyclase activating polypeptide 1	Rattus norvegicus	51-56
8943781-7	1996	As shown by the treatment with phorbol-myristate-acetate in vitamin D-differentiated monocytic leukemia THP1 cells, steroid synthesis and inactivation are regulated differentially by the protein kinase C pathway: an increase in aromatase is accompanied by a decrease in 17 beta-HSD IV mRNA levels.	Tetradecanoylphorbol Acetate	31-56	hydroxysteroid 17-beta dehydrogenase 4	Homo sapiens	270-284
10400418-5	1999	In comparison, the stimulation of Raf-1 by phorbol ester (TPA) activates the MAPK pathway, causes MAPK-dependent p21WAF1/CIP1 induction, Rb dephosphorylation and growth arrest without Bcl-2 phosphorylation or apoptosis.	Tetradecanoylphorbol Acetate	58-61	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
8083194-5	1994	Expression of PGHS protein was regulated correspondingly; whereas PGHS-1 protein was constitutively expressed, PGHS-2 protein was virtually absent in unstimulated cells, but could increasingly be induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), 5-HT, or fetal calf serum.	Tetradecanoylphorbol Acetate	225-261	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	111-117
8083194-5	1994	Expression of PGHS protein was regulated correspondingly; whereas PGHS-1 protein was constitutively expressed, PGHS-2 protein was virtually absent in unstimulated cells, but could increasingly be induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), 5-HT, or fetal calf serum.	Tetradecanoylphorbol Acetate	263-266	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	111-117
8083194-8	1994	Induction of PGHS-2 mRNA by 5-HT was dependent on protein kinase C. Down-regulation of the enzyme by prolonged incubation with TPA abolished 5-HT-induced PGHS-2 mRNA expression.	Tetradecanoylphorbol Acetate	127-130	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	13-19
8899553-6	1996	Ecto-5"-nucleotidase activity increased 15 min after the onset of an exposure to either methoxamine or PMA.	Tetradecanoylphorbol Acetate	103-106	5' nucleotidase, ecto	Rattus norvegicus	0-20
8083194-8	1994	Induction of PGHS-2 mRNA by 5-HT was dependent on protein kinase C. Down-regulation of the enzyme by prolonged incubation with TPA abolished 5-HT-induced PGHS-2 mRNA expression.	Tetradecanoylphorbol Acetate	127-130	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	154-160
10373683-9	1999	In one-stage treatment (5 h-24 h), only the promoter TPA induces ODC activity, while other carcinogens do not increase this activity.	Tetradecanoylphorbol Acetate	53-56	ornithine decarboxylase 1	Homo sapiens	65-68
8083194-9	1994	Short time activation of protein kinase C by TPA induced PGHS-2 mRNA expression.	Tetradecanoylphorbol Acetate	45-48	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	57-63
8083194-10	1994	On the other hand, TPA given immediately before 5-HT decreased the 5-HT-induced PGHS-2 mRNA expression, indicating a negative feedback.	Tetradecanoylphorbol Acetate	19-22	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	80-86
7812608-2	1994	The mouse AtT-20/D16-16 anterior pituitary tumour cell line was used as a model system for the study of phorbol 12-myristate 13-acetate (PMA)-mediated enhancement of calcium-evoked adrenocorticotrophin (ACTH) secretion.	Tetradecanoylphorbol Acetate	104-135	pro-opiomelanocortin-alpha	Mus musculus	203-207
8899553-7	1996	Adenosine release during hypoxia and reperfusion was augmented in the methoxamine- and PMA-pretreated cardiomyocytes compared with the untreated cardiomyocytes, which was inhibited by alpha, beta-methyleneadenosine 5"-diphosphate (AOPCP), an inhibitor of ecto-5"-nucleotidase.	Tetradecanoylphorbol Acetate	87-90	5' nucleotidase, ecto	Rattus norvegicus	255-275
10373683-10	1999	Using the two-stage exposure protocol (1 h xenobiotic/5 h TPA), all carcinogens both genotoxic and non-genotoxic, are able to stimulate ODC activity above the level obtained with TPA alone.	Tetradecanoylphorbol Acetate	58-61	ornithine decarboxylase 1	Homo sapiens	136-139
7812608-2	1994	The mouse AtT-20/D16-16 anterior pituitary tumour cell line was used as a model system for the study of phorbol 12-myristate 13-acetate (PMA)-mediated enhancement of calcium-evoked adrenocorticotrophin (ACTH) secretion.	Tetradecanoylphorbol Acetate	137-140	pro-opiomelanocortin-alpha	Mus musculus	203-207
7812608-8	1994	Calcium stimulated ACTH secretion from electrically-permeabilized cells over the concentration-range of 10(-7) M to 10(-5) M. PMA (10(-7) M) enhanced the amount of ACTH secreted at every concentration of calcium investigated.	Tetradecanoylphorbol Acetate	126-129	pro-opiomelanocortin-alpha	Mus musculus	19-23
10373683-10	1999	Using the two-stage exposure protocol (1 h xenobiotic/5 h TPA), all carcinogens both genotoxic and non-genotoxic, are able to stimulate ODC activity above the level obtained with TPA alone.	Tetradecanoylphorbol Acetate	179-182	ornithine decarboxylase 1	Homo sapiens	136-139
7812608-8	1994	Calcium stimulated ACTH secretion from electrically-permeabilized cells over the concentration-range of 10(-7) M to 10(-5) M. PMA (10(-7) M) enhanced the amount of ACTH secreted at every concentration of calcium investigated.	Tetradecanoylphorbol Acetate	126-129	pro-opiomelanocortin-alpha	Mus musculus	164-168
8876673-5	1996	Compared with parental cotransport-deficient cells, transfected clones expressing the exogenous NKCC1 gene responded like typical BALB/c 3T3 cells to 12-O-tetradecanoylphorbol-13-acetate: loop diuretic-sensitive 86Rb+ flux was inhibited, cell volume was decreased, and cell growth was stimulated.	Tetradecanoylphorbol Acetate	150-186	solute carrier family 12, member 2	Mus musculus	96-101
7812608-9	1994	The PKC inhibitor, chelerythrine (10(-5) M) blocked the PMA (10(-7) M)-evoked enhancement of calcium (10(-5) M)-stimulated ACTH secretion but did not alter significantly the calcium (10(-5) M)-evoked secretion itself.	Tetradecanoylphorbol Acetate	56-59	pro-opiomelanocortin-alpha	Mus musculus	123-127
10362531-1	1999	Activation of the neutrophil NADPH oxidase by either the bacterial peptide fMLP or phorbol myristate acetate (PMA) is partially suppressed by SB 203580, a specific inhibitor of the MAP kinase family member, SAPK2/p38.	Tetradecanoylphorbol Acetate	83-108	mitogen-activated protein kinase 11	Homo sapiens	207-212
7812608-16	1994	Chelerythrine (10-s M) blocked the PMA (10-7 M)-evoked enhancement of GTP-gamma-S (10-4 M)-stimulated ACTH secretion but did not significantly alter GTP-gamma-S(10-4 M)-evoked secretion itself.	Tetradecanoylphorbol Acetate	35-38	pro-opiomelanocortin-alpha	Mus musculus	102-106
7812608-21	1994	PMA, unlike adenosine 3":5"-cyclic monophosphate (cyclic AMP) (Guild, 1991), can stimulate ACTH secretion from permeabilized cells in the absence of added calcium and guanine nucleotides which suggests that PMA and cyclic AMP are acting through distinct mechanisms at this post calcium site of action.	Tetradecanoylphorbol Acetate	0-3	pro-opiomelanocortin-alpha	Mus musculus	91-95
8880976-4	1996	[Ca2+]i signalling of neutrophils from control heifers and a heifer with BLAD stimulated with phorbol myristate acetate via an 11b/CD18-independent pathway showed no transient phase, and the subsequent increase in [Ca2+]i was almost identical in neutrophils from affected and control heifers.	Tetradecanoylphorbol Acetate	94-119	integrin subunit beta 2	Bos taurus	131-135
8687492-11	1996	H7 (30 microM) completely inhibited PMA-induced translocations of PKC delta and epsilon, whereas it only partially blocked the translocations of PKC alpha and beta.	Tetradecanoylphorbol Acetate	36-39	protein kinase C delta	Homo sapiens	66-75
10362531-1	1999	Activation of the neutrophil NADPH oxidase by either the bacterial peptide fMLP or phorbol myristate acetate (PMA) is partially suppressed by SB 203580, a specific inhibitor of the MAP kinase family member, SAPK2/p38.	Tetradecanoylphorbol Acetate	110-113	mitogen-activated protein kinase 11	Homo sapiens	207-212
8663346-14	1996	These data suggest that distinct pathways mediate the effects of GH, DEX, and PMA on GHR number in the plasma membrane.	Tetradecanoylphorbol Acetate	78-81	growth hormone receptor	Cricetulus griseus	85-88
7956827-5	1994	Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol-13-acetate (TPA) causes a rapid increase in the level of ks1 mRNA in head-specific epithelial cells and also induces ectopic ks1 expression in cells of the gastric region.	Tetradecanoylphorbol Acetate	46-82	zinc finger protein 382	Homo sapiens	129-132
10421059-3	1999	A single topical application of 12-O-tetradecanoyl-phorbol 13-acetate induced epidermal hyperplasia and simultaneously induced an extensive increase in neuropsin mRNA in the suprabasal cells.	Tetradecanoylphorbol Acetate	32-69	opsin 5	Mus musculus	152-161
7956827-5	1994	Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol-13-acetate (TPA) causes a rapid increase in the level of ks1 mRNA in head-specific epithelial cells and also induces ectopic ks1 expression in cells of the gastric region.	Tetradecanoylphorbol Acetate	46-82	zinc finger protein 382	Homo sapiens	197-200
7956827-5	1994	Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol-13-acetate (TPA) causes a rapid increase in the level of ks1 mRNA in head-specific epithelial cells and also induces ectopic ks1 expression in cells of the gastric region.	Tetradecanoylphorbol Acetate	84-87	zinc finger protein 382	Homo sapiens	129-132
7956827-5	1994	Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol-13-acetate (TPA) causes a rapid increase in the level of ks1 mRNA in head-specific epithelial cells and also induces ectopic ks1 expression in cells of the gastric region.	Tetradecanoylphorbol Acetate	84-87	zinc finger protein 382	Homo sapiens	197-200
8083760-6	1994	Treatment with either TGF alpha or its structural homolog, epidermal growth factor (EGF), increased TGF alpha mRNA levels within 8 hr of exposure; the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was similarly effective.	Tetradecanoylphorbol Acetate	165-202	transforming growth factor alpha	Homo sapiens	22-31
8083760-6	1994	Treatment with either TGF alpha or its structural homolog, epidermal growth factor (EGF), increased TGF alpha mRNA levels within 8 hr of exposure; the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was similarly effective.	Tetradecanoylphorbol Acetate	204-207	transforming growth factor alpha	Homo sapiens	22-31
8083760-6	1994	Treatment with either TGF alpha or its structural homolog, epidermal growth factor (EGF), increased TGF alpha mRNA levels within 8 hr of exposure; the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was similarly effective.	Tetradecanoylphorbol Acetate	204-207	transforming growth factor alpha	Homo sapiens	100-109
8702428-3	1996	In this study, we examined the effect of RA on expression of IL-1 beta and IL-ra in phorbol-myristate-acetate (PMA)-activated human monocytes.	Tetradecanoylphorbol Acetate	84-109	interleukin 7 receptor	Homo sapiens	75-80
8702428-3	1996	In this study, we examined the effect of RA on expression of IL-1 beta and IL-ra in phorbol-myristate-acetate (PMA)-activated human monocytes.	Tetradecanoylphorbol Acetate	111-114	interleukin 7 receptor	Homo sapiens	75-80
8688322-5	1996	The addition of phorbol-12-myristate-13-acetate to the medium significantly increased PTHrP secretion from the cells.	Tetradecanoylphorbol Acetate	16-47	parathyroid hormone like hormone	Homo sapiens	86-91
10352098-9	1999	In KPDXM cells, PTHrP was not detected in culture media under basal experimental conditions, and barely detectable amounts were present in cell extracts of TPA-treated cells, although the mRNA levels increased substantially in response to TPA.	Tetradecanoylphorbol Acetate	239-242	parathyroid hormone like hormone	Homo sapiens	16-21
7969791-6	1994	Phorbol-12-myristate-13-acetate (PMA; 10(-6) M), a protein kinase C (PKC) activator, diminished PPII activity to 61% or initial values with an ED50 of 2.2 x 10(-8) M. Maximal effects of PMA and TRH were not additive.	Tetradecanoylphorbol Acetate	0-31	thyrotropin releasing hormone	Homo sapiens	194-197
7969791-6	1994	Phorbol-12-myristate-13-acetate (PMA; 10(-6) M), a protein kinase C (PKC) activator, diminished PPII activity to 61% or initial values with an ED50 of 2.2 x 10(-8) M. Maximal effects of PMA and TRH were not additive.	Tetradecanoylphorbol Acetate	33-36	thyrotropin releasing hormone	Homo sapiens	194-197
8756339-8	1996	The activity of the rat MPG promoter was found to be inducible by the tumor promoter TPA and UV light, but not to a significant extent by methylating agents and ionizing radiation.	Tetradecanoylphorbol Acetate	85-88	N-methylpurine-DNA glycosylase	Rattus norvegicus	24-27
8058309-4	1994	Similar down-regulation of nm23-H1 mRNA was also observed in the induced differentiation of the promyelocytic leukemia line HL-60 by TPA, or DMSO into monocyte-macrophage lineage or granulocytes, respectively.	Tetradecanoylphorbol Acetate	133-136	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	27-34
10380899-5	1999	This indicates that accompanying activation of LFA-1, TPA induces the polyubiquitination of the membrane proteins, which are rapidly degraded by proteasomes.	Tetradecanoylphorbol Acetate	54-57	integrin subunit alpha L	Homo sapiens	47-52
8093097-0	1994	Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C. Cyclosporin A (CsA) has been reported to inhibit phorbol myristate acetate (PMA)-induced superoxide anion (O2-) formation in human neutrophils and murine macrophages.	Tetradecanoylphorbol Acetate	215-240	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	181-184
10380902-2	1999	Because many SNARE proteins appear to be common mediators of exocytosis, we examined phorbol myristate acetate-stimulated expression of CD11b and CD69 on polymorphonuclear leukocytes (PMN) from Type 2 diabetic subjects with hypertension and microalbuminuria (D-htma), hypertension only (D-ht) or uncomplicated (D-uc), and normal controls (NC) by flow cytometry.	Tetradecanoylphorbol Acetate	85-110	CD69 molecule	Homo sapiens	146-150
8093097-0	1994	Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C. Cyclosporin A (CsA) has been reported to inhibit phorbol myristate acetate (PMA)-induced superoxide anion (O2-) formation in human neutrophils and murine macrophages.	Tetradecanoylphorbol Acetate	242-245	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	181-184
8668145-1	1996	12-O-Tetradecanoylphorbol-13-acetate (TPA) stimulation of PU-34 cells, a primate bone marrow stromal cell line, resulted in a prolonged elevation of interleukin-11 (IL-11) mRNA, which can be inhibited by protein synthesis inhibitors.	Tetradecanoylphorbol Acetate	0-36	LOC102118349	Macaca fascicularis	149-163
8668145-1	1996	12-O-Tetradecanoylphorbol-13-acetate (TPA) stimulation of PU-34 cells, a primate bone marrow stromal cell line, resulted in a prolonged elevation of interleukin-11 (IL-11) mRNA, which can be inhibited by protein synthesis inhibitors.	Tetradecanoylphorbol Acetate	0-36	LOC102118349	Macaca fascicularis	165-170
10365914-3	1999	HK1.IGF1 transgenic mice, which overexpress IGF-1 in epidermis via the human keratin 1 promoter, were previously shown to be hypersensitive to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	167-203	insulin-like growth factor 1	Mus musculus	4-8
8668145-1	1996	12-O-Tetradecanoylphorbol-13-acetate (TPA) stimulation of PU-34 cells, a primate bone marrow stromal cell line, resulted in a prolonged elevation of interleukin-11 (IL-11) mRNA, which can be inhibited by protein synthesis inhibitors.	Tetradecanoylphorbol Acetate	38-41	LOC102118349	Macaca fascicularis	149-163
8668145-1	1996	12-O-Tetradecanoylphorbol-13-acetate (TPA) stimulation of PU-34 cells, a primate bone marrow stromal cell line, resulted in a prolonged elevation of interleukin-11 (IL-11) mRNA, which can be inhibited by protein synthesis inhibitors.	Tetradecanoylphorbol Acetate	38-41	LOC102118349	Macaca fascicularis	165-170
8668145-3	1996	Inhibition of PKC activity by calphostin C generated an IL-11 mRNA degradation intermediate in TPA-stimulated PU-34 cells.	Tetradecanoylphorbol Acetate	95-98	LOC102118349	Macaca fascicularis	56-61
8063765-10	1994	Furthermore, RA inhibited activator protein-1 binding to 12-O-tetradecanoylphorbol 13-acetate-response element (TRE) in the cells treated with TNF-alpha, suggesting that RA acts as a potent negative regulator for activator protein-1 binding activity to TRE in the osteoblastic cells.	Tetradecanoylphorbol Acetate	57-93	jun proto-oncogene	Mus musculus	26-45
8063765-10	1994	Furthermore, RA inhibited activator protein-1 binding to 12-O-tetradecanoylphorbol 13-acetate-response element (TRE) in the cells treated with TNF-alpha, suggesting that RA acts as a potent negative regulator for activator protein-1 binding activity to TRE in the osteoblastic cells.	Tetradecanoylphorbol Acetate	57-93	jun proto-oncogene	Mus musculus	213-232
8668145-7	1996	Our study suggests that multiple regions within the IL-11 mRNA are involved in TPA-stimulated IL-11 mRNA stabilization, possibly through a unique RNA folding conformation involving interactions of various RNA sequences within the IL-11 mRNA molecule.	Tetradecanoylphorbol Acetate	79-82	LOC102118349	Macaca fascicularis	52-57
10365914-3	1999	HK1.IGF1 transgenic mice, which overexpress IGF-1 in epidermis via the human keratin 1 promoter, were previously shown to be hypersensitive to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	167-203	insulin-like growth factor 1	Mus musculus	44-49
8668145-7	1996	Our study suggests that multiple regions within the IL-11 mRNA are involved in TPA-stimulated IL-11 mRNA stabilization, possibly through a unique RNA folding conformation involving interactions of various RNA sequences within the IL-11 mRNA molecule.	Tetradecanoylphorbol Acetate	79-82	LOC102118349	Macaca fascicularis	94-99
8668145-7	1996	Our study suggests that multiple regions within the IL-11 mRNA are involved in TPA-stimulated IL-11 mRNA stabilization, possibly through a unique RNA folding conformation involving interactions of various RNA sequences within the IL-11 mRNA molecule.	Tetradecanoylphorbol Acetate	79-82	LOC102118349	Macaca fascicularis	94-99
7805772-2	1994	Effects of endothelin ETA receptor stimulation were mimicked by application of PMA (4-beta-phorbol 12-myristate 13-acetate; 0.1 microM) or intracellular injection of CaCl2 (estimated concentration of 1 microM).	Tetradecanoylphorbol Acetate	79-82	endothelin receptor type A	Rattus norvegicus	22-25
7805772-2	1994	Effects of endothelin ETA receptor stimulation were mimicked by application of PMA (4-beta-phorbol 12-myristate 13-acetate; 0.1 microM) or intracellular injection of CaCl2 (estimated concentration of 1 microM).	Tetradecanoylphorbol Acetate	84-122	endothelin receptor type A	Rattus norvegicus	22-25
10365914-3	1999	HK1.IGF1 transgenic mice, which overexpress IGF-1 in epidermis via the human keratin 1 promoter, were previously shown to be hypersensitive to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	167-203	keratin 1	Homo sapiens	77-86
7915087-4	1994	In THP-1 macrophages, histamine inhibited 4 beta-phorbol 12-myristate 13-acetate (PMA)-induced H2O2 formation via the activation of H2 receptors.	Tetradecanoylphorbol Acetate	44-80	histamine receptor H2	Homo sapiens	132-144
7915087-4	1994	In THP-1 macrophages, histamine inhibited 4 beta-phorbol 12-myristate 13-acetate (PMA)-induced H2O2 formation via the activation of H2 receptors.	Tetradecanoylphorbol Acetate	82-85	histamine receptor H2	Homo sapiens	132-144
10365914-3	1999	HK1.IGF1 transgenic mice, which overexpress IGF-1 in epidermis via the human keratin 1 promoter, were previously shown to be hypersensitive to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	205-208	insulin-like growth factor 1	Mus musculus	4-8
10365914-3	1999	HK1.IGF1 transgenic mice, which overexpress IGF-1 in epidermis via the human keratin 1 promoter, were previously shown to be hypersensitive to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	205-208	insulin-like growth factor 1	Mus musculus	44-49
10329716-6	1999	Mutation of Ser302 decreased the level of phosphorylation of exogenously expressed K protein in phorbol 12-myristate 13-acetate-treated COS cells, suggesting that Ser302 is also a site for PKC-mediated phosphorylation in vivo.	Tetradecanoylphorbol Acetate	96-127	protein kinase C delta	Homo sapiens	189-192
8045498-5	1994	Interleukin-1 beta and phorbol myristate acetate were also shown to induce in a dose-dependent fashion a threefold to fivefold increase of interleukin-6 production as measured by enzyme-linked immunosorbent assay in human primary biliary duct epithelium cultures, when compared with hepatocyte growth factor, epidermal growth factor, insulin-like growth factor, phytohemagglutinin, tumor necrosis factor-alpha or platelet-derived growth factor.	Tetradecanoylphorbol Acetate	23-48	hepatocyte growth factor	Homo sapiens	283-307
8035193-2	1994	We found that the protein kinase C activator phorbol 12-myristate 13-acetate administered intracerebroventricularly transiently increased AAAD activity by 30-50% over control values within approximately 30 min in the striatum and midbrain of the mouse.	Tetradecanoylphorbol Acetate	45-76	dopa decarboxylase	Mus musculus	138-142
8692823-5	1996	This mutation impaired Tat responsiveness of the LTR in transient transfection assays, and the measured defect was complemented in cells that had been treated with tetradecanoyl phorbol acetate or tumor necrosis factor type alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	164-193	tyrosine aminotransferase	Homo sapiens	23-26
8690086-2	1996	In T84 human epithelia] cells 12-O-tetradecanoyl phorbol 13-acetate (TPA) caused persistent translocation of PKC delta to the membrane compartment and a 400% increase of PKC delta-mRNA after 24 h. In contrast, PKC alpha protein was completely downregulated and its mRNA was decreased to 60% of control levels after 24 h. This is the first report of PKC delta-mRNA upregulation by TPA which was previously only shown for PKCbeta.	Tetradecanoylphorbol Acetate	30-67	protein kinase C delta	Homo sapiens	109-118
8690086-2	1996	In T84 human epithelia] cells 12-O-tetradecanoyl phorbol 13-acetate (TPA) caused persistent translocation of PKC delta to the membrane compartment and a 400% increase of PKC delta-mRNA after 24 h. In contrast, PKC alpha protein was completely downregulated and its mRNA was decreased to 60% of control levels after 24 h. This is the first report of PKC delta-mRNA upregulation by TPA which was previously only shown for PKCbeta.	Tetradecanoylphorbol Acetate	30-67	protein kinase C delta	Homo sapiens	170-179
8690086-2	1996	In T84 human epithelia] cells 12-O-tetradecanoyl phorbol 13-acetate (TPA) caused persistent translocation of PKC delta to the membrane compartment and a 400% increase of PKC delta-mRNA after 24 h. In contrast, PKC alpha protein was completely downregulated and its mRNA was decreased to 60% of control levels after 24 h. This is the first report of PKC delta-mRNA upregulation by TPA which was previously only shown for PKCbeta.	Tetradecanoylphorbol Acetate	30-67	protein kinase C delta	Homo sapiens	170-179
8690086-2	1996	In T84 human epithelia] cells 12-O-tetradecanoyl phorbol 13-acetate (TPA) caused persistent translocation of PKC delta to the membrane compartment and a 400% increase of PKC delta-mRNA after 24 h. In contrast, PKC alpha protein was completely downregulated and its mRNA was decreased to 60% of control levels after 24 h. This is the first report of PKC delta-mRNA upregulation by TPA which was previously only shown for PKCbeta.	Tetradecanoylphorbol Acetate	30-67	protein kinase C beta	Homo sapiens	420-427
10202185-6	1999	Phorbol 12-myristate 13-acetate (TPA) treatment of PC for 15, 30 and 60 sec decreased significantly cytosolic PKC-alpha and increased membrane-associated PKC-alpha.	Tetradecanoylphorbol Acetate	0-31	protein kinase C alpha type	Oryctolagus cuniculus	110-119
8690086-2	1996	In T84 human epithelia] cells 12-O-tetradecanoyl phorbol 13-acetate (TPA) caused persistent translocation of PKC delta to the membrane compartment and a 400% increase of PKC delta-mRNA after 24 h. In contrast, PKC alpha protein was completely downregulated and its mRNA was decreased to 60% of control levels after 24 h. This is the first report of PKC delta-mRNA upregulation by TPA which was previously only shown for PKCbeta.	Tetradecanoylphorbol Acetate	69-72	protein kinase C delta	Homo sapiens	109-118
8690086-2	1996	In T84 human epithelia] cells 12-O-tetradecanoyl phorbol 13-acetate (TPA) caused persistent translocation of PKC delta to the membrane compartment and a 400% increase of PKC delta-mRNA after 24 h. In contrast, PKC alpha protein was completely downregulated and its mRNA was decreased to 60% of control levels after 24 h. This is the first report of PKC delta-mRNA upregulation by TPA which was previously only shown for PKCbeta.	Tetradecanoylphorbol Acetate	69-72	protein kinase C delta	Homo sapiens	170-179
8690086-2	1996	In T84 human epithelia] cells 12-O-tetradecanoyl phorbol 13-acetate (TPA) caused persistent translocation of PKC delta to the membrane compartment and a 400% increase of PKC delta-mRNA after 24 h. In contrast, PKC alpha protein was completely downregulated and its mRNA was decreased to 60% of control levels after 24 h. This is the first report of PKC delta-mRNA upregulation by TPA which was previously only shown for PKCbeta.	Tetradecanoylphorbol Acetate	69-72	protein kinase C delta	Homo sapiens	170-179
8690086-2	1996	In T84 human epithelia] cells 12-O-tetradecanoyl phorbol 13-acetate (TPA) caused persistent translocation of PKC delta to the membrane compartment and a 400% increase of PKC delta-mRNA after 24 h. In contrast, PKC alpha protein was completely downregulated and its mRNA was decreased to 60% of control levels after 24 h. This is the first report of PKC delta-mRNA upregulation by TPA which was previously only shown for PKCbeta.	Tetradecanoylphorbol Acetate	69-72	protein kinase C beta	Homo sapiens	420-427
8663019-15	1996	The demonstration that inhibition of TPA-induced PA formation inhibits Raf-1 translocation in MDCK cells (Ghosh, S., Strum, J. C., Sciorra, V. A., Daniel, L. W. , and Bell, R. M. (1996) J. Biol.	Tetradecanoylphorbol Acetate	37-40	Raf-1 proto-oncogene, serine/threonine kinase	Canis lupus familiaris	71-76
8964847-15	1996	These effects of AII cotreatment on expression of P450c17 and P450scc were reproduced by cotreatment with TPA (10 nmol/L), suggesting the involvement of protein kinase C in these attenuative responses.	Tetradecanoylphorbol Acetate	106-109	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	50-57
8037686-1	1994	We have reported that the phorbol ester phorbol 12-myristate 13-acetate (PMA) enhances the expression of manganese superoxide dismutase (Mn-SOD) mRNA [Fujii and Taniguchi (1991) J. Biol.	Tetradecanoylphorbol Acetate	40-71	superoxide dismutase 2	Homo sapiens	105-135
8037686-1	1994	We have reported that the phorbol ester phorbol 12-myristate 13-acetate (PMA) enhances the expression of manganese superoxide dismutase (Mn-SOD) mRNA [Fujii and Taniguchi (1991) J. Biol.	Tetradecanoylphorbol Acetate	40-71	superoxide dismutase 2	Homo sapiens	137-143
8037686-1	1994	We have reported that the phorbol ester phorbol 12-myristate 13-acetate (PMA) enhances the expression of manganese superoxide dismutase (Mn-SOD) mRNA [Fujii and Taniguchi (1991) J. Biol.	Tetradecanoylphorbol Acetate	73-76	superoxide dismutase 2	Homo sapiens	105-135
8037686-1	1994	We have reported that the phorbol ester phorbol 12-myristate 13-acetate (PMA) enhances the expression of manganese superoxide dismutase (Mn-SOD) mRNA [Fujii and Taniguchi (1991) J. Biol.	Tetradecanoylphorbol Acetate	73-76	superoxide dismutase 2	Homo sapiens	137-143
7517212-7	1994	Flow cytometry showed a TPA-induced increase in HLA-DR expression, and Northern blot analysis showed induction of expression of CD18, c-fos, and human neutrophil gelatinase (HNG).	Tetradecanoylphorbol Acetate	24-27	neurogranin	Homo sapiens	174-177
7517212-9	1994	This again parallels our findings in TPA-induced HL60 cells, which retain the ability to express HNG.	Tetradecanoylphorbol Acetate	37-40	neurogranin	Homo sapiens	97-100
7981979-4	1994	Acute treatment with PMA resulted in translocation of the PKC-alpha from the cytosol to the membrane fraction in both cell types.	Tetradecanoylphorbol Acetate	21-24	protein kinase C alpha type	Oryctolagus cuniculus	58-67
7981979-5	1994	Prolonged exposure of the villus cells to PMA resulted in a significant progressive decrement in PKC-alpha, suggesting down regulation.	Tetradecanoylphorbol Acetate	42-45	protein kinase C alpha type	Oryctolagus cuniculus	97-106
10202185-6	1999	Phorbol 12-myristate 13-acetate (TPA) treatment of PC for 15, 30 and 60 sec decreased significantly cytosolic PKC-alpha and increased membrane-associated PKC-alpha.	Tetradecanoylphorbol Acetate	0-31	protein kinase C alpha type	Oryctolagus cuniculus	154-163
8632179-6	1996	TPA, basic fibroblast growth factor, and the proinflammatory factors tumor necrosis factor alpha and lipopolysaccharide, but not interleukin-6, also stimulated PGHS-2 mRNA expression.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	160-166
10202185-6	1999	Phorbol 12-myristate 13-acetate (TPA) treatment of PC for 15, 30 and 60 sec decreased significantly cytosolic PKC-alpha and increased membrane-associated PKC-alpha.	Tetradecanoylphorbol Acetate	33-36	protein kinase C alpha type	Oryctolagus cuniculus	110-119
7983166-4	1994	These included: (i) a dramatic decrease in the expression of cyclin A, cyclin B and cdk2, and surprisingly an up-regulation of cyclin D1 in TPA-induced macrophage-like cells; (ii) a down-regulation of cyclin E in retinoic acid-induced granulocytic cells; and (iii) a decreased abundance of cyclin D1 and D2, but high levels of cyclin A, B and E RNA in DMSO-induced granulocytic cells.	Tetradecanoylphorbol Acetate	140-143	cyclin D1	Homo sapiens	127-136
10202185-6	1999	Phorbol 12-myristate 13-acetate (TPA) treatment of PC for 15, 30 and 60 sec decreased significantly cytosolic PKC-alpha and increased membrane-associated PKC-alpha.	Tetradecanoylphorbol Acetate	33-36	protein kinase C alpha type	Oryctolagus cuniculus	154-163
7983166-4	1994	These included: (i) a dramatic decrease in the expression of cyclin A, cyclin B and cdk2, and surprisingly an up-regulation of cyclin D1 in TPA-induced macrophage-like cells; (ii) a down-regulation of cyclin E in retinoic acid-induced granulocytic cells; and (iii) a decreased abundance of cyclin D1 and D2, but high levels of cyclin A, B and E RNA in DMSO-induced granulocytic cells.	Tetradecanoylphorbol Acetate	140-143	cyclin D1	Homo sapiens	290-299
8793856-4	1996	Reverse transcription-polymerase chain reaction (RT-PCR) analysis was performed to estimate the c-jun and c-fos mRNA contents in GnRH-, forskolin- (cAMP activator) and tetradecanoyl phorbol acetate- (TPA; protein kinase C activator) treated primary cultures of porcine anterior pituitary cells.	Tetradecanoylphorbol Acetate	200-203	gonadotropin releasing hormone 1	Homo sapiens	129-133
10202185-8	1999	Comparison of the dose-response curves between TPA-induced hydrogen (H+) secretion, as measured by aminopyrine (AP) uptake, and the membrane-associated PKC-alpha suggests that translocation of PKC-alpha is not involved in the H+ secretory process in PC.	Tetradecanoylphorbol Acetate	47-50	protein kinase C alpha type	Oryctolagus cuniculus	193-202
10199818-1	1999	The cloned epithelial cell-specific Na+/H+ exchanger (NHE) isoform NHE2 is stimulated by fibroblast growth factor (FGF), phorbol 12-myristate 13-acetate (PMA), okadaic acid (OA), and fetal bovine serum (FBS) through a change in maximal velocity of the transporter.	Tetradecanoylphorbol Acetate	121-152	solute carrier family 9 member C1	Homo sapiens	36-52
8732677-3	1996	All of the K6-TGF beta 1 transgenic lines studied showed attenuation of the basal keratinocyte proliferative response to 12-O-tetradecanoylphorbol-13-acetate as a consequence of inducible TGF beta 1 gene expression.	Tetradecanoylphorbol Acetate	121-157	transforming growth factor, beta 1	Mus musculus	14-24
7999678-4	1994	Using an enzyme immuno assay, HGF immunoreactivities were not detected in conditioned media of DPC that were either non-treated or treated with TGF-beta, but were detected in conditioned media of DPC treated with IL1-alpha, TNF-alpha and TPA.	Tetradecanoylphorbol Acetate	238-241	hepatocyte growth factor	Homo sapiens	30-33
7912755-6	1994	On liquid culture with or without 5 x 10(-9) M 12-O-tetradecanoylphorbol-13-acetate (TPA) for 3 days, the blasts formed aggregates of proliferating and elongating cells on the wall of the flasks with a decline in CD34, numerous dendritic processes appeared on the cells and there was strong positivity for ATPase/ADPase, but no other changes in phenotype.	Tetradecanoylphorbol Acetate	47-83	dynein axonemal heavy chain 8	Homo sapiens	306-312
7912755-6	1994	On liquid culture with or without 5 x 10(-9) M 12-O-tetradecanoylphorbol-13-acetate (TPA) for 3 days, the blasts formed aggregates of proliferating and elongating cells on the wall of the flasks with a decline in CD34, numerous dendritic processes appeared on the cells and there was strong positivity for ATPase/ADPase, but no other changes in phenotype.	Tetradecanoylphorbol Acetate	85-88	dynein axonemal heavy chain 8	Homo sapiens	306-312
8195229-2	1994	Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	290-326	insulin receptor	Homo sapiens	233-249
10199818-1	1999	The cloned epithelial cell-specific Na+/H+ exchanger (NHE) isoform NHE2 is stimulated by fibroblast growth factor (FGF), phorbol 12-myristate 13-acetate (PMA), okadaic acid (OA), and fetal bovine serum (FBS) through a change in maximal velocity of the transporter.	Tetradecanoylphorbol Acetate	121-152	solute carrier family 9 member C1	Homo sapiens	54-57
8195229-2	1994	Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	328-331	insulin receptor	Homo sapiens	233-249
8195229-3	1994	Moreover, we show that overexpression of MAPK in CHO-HIR cells resulted in enhanced hyperphosphorylation of Raf-1, MAPKK, and mammalian homolog of son of sevenless (mSos) after insulin or TPA stimulation as compared with parental cells.	Tetradecanoylphorbol Acetate	188-191	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	108-113
8195229-5	1994	These results suggest that 1) signals initiated by insulin and TPA converge on Raf-1 and activate its MAPKKK activity and 2) Raf-1, MAPKK, and mSos not only lie upstream of MAPK but also are phosphorylated by MAPK, directly or indirectly, and at least Raf-1 kinase activity might be down-regulated by this feedback mechanism.	Tetradecanoylphorbol Acetate	63-66	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	79-84
8708540-6	1996	Both PACAP- and VIP-stimulated cAMP accumulation were potentiated by 4 beta-phorbol 12-myristate 13-acetate, an activator of protein kinase C. Two PACAP antagonists, PACAP 6-27 (3 x 10(-6) M) and PACAP 6-38 (3 x 10(-6) M), blocked PACAP- and VIP-stimulated cAMP accumulation.	Tetradecanoylphorbol Acetate	69-107	adenylate cyclase activating polypeptide 1	Rattus norvegicus	5-10
8708540-6	1996	Both PACAP- and VIP-stimulated cAMP accumulation were potentiated by 4 beta-phorbol 12-myristate 13-acetate, an activator of protein kinase C. Two PACAP antagonists, PACAP 6-27 (3 x 10(-6) M) and PACAP 6-38 (3 x 10(-6) M), blocked PACAP- and VIP-stimulated cAMP accumulation.	Tetradecanoylphorbol Acetate	69-107	adenylate cyclase activating polypeptide 1	Rattus norvegicus	147-152
8708540-6	1996	Both PACAP- and VIP-stimulated cAMP accumulation were potentiated by 4 beta-phorbol 12-myristate 13-acetate, an activator of protein kinase C. Two PACAP antagonists, PACAP 6-27 (3 x 10(-6) M) and PACAP 6-38 (3 x 10(-6) M), blocked PACAP- and VIP-stimulated cAMP accumulation.	Tetradecanoylphorbol Acetate	69-107	adenylate cyclase activating polypeptide 1	Rattus norvegicus	147-152
8194473-6	1994	The effect of AII on AT1-R mRNA levels was fully reproduced by the combination of calcium ionophore (A23187) and phorbol ester (12-O-tetradecanoylphorbol 13-acetate), suggesting that AII action was through protein kinase-C and possibly other Ca(2+)-sensitive protein kinases.	Tetradecanoylphorbol Acetate	128-164	angiotensin II receptor type 1	Homo sapiens	21-26
10199818-1	1999	The cloned epithelial cell-specific Na+/H+ exchanger (NHE) isoform NHE2 is stimulated by fibroblast growth factor (FGF), phorbol 12-myristate 13-acetate (PMA), okadaic acid (OA), and fetal bovine serum (FBS) through a change in maximal velocity of the transporter.	Tetradecanoylphorbol Acetate	154-157	solute carrier family 9 member C1	Homo sapiens	36-52
10199818-1	1999	The cloned epithelial cell-specific Na+/H+ exchanger (NHE) isoform NHE2 is stimulated by fibroblast growth factor (FGF), phorbol 12-myristate 13-acetate (PMA), okadaic acid (OA), and fetal bovine serum (FBS) through a change in maximal velocity of the transporter.	Tetradecanoylphorbol Acetate	154-157	solute carrier family 9 member C1	Homo sapiens	54-57
8195119-9	1994	The protein kinase C activator phorbol 12-myristate 13-acetate modulates DAO receptor number by 35% and total histamine degradative uptake by &gt; 2-fold.	Tetradecanoylphorbol Acetate	31-62	amine oxidase copper containing 1	Homo sapiens	73-76
8708540-6	1996	Both PACAP- and VIP-stimulated cAMP accumulation were potentiated by 4 beta-phorbol 12-myristate 13-acetate, an activator of protein kinase C. Two PACAP antagonists, PACAP 6-27 (3 x 10(-6) M) and PACAP 6-38 (3 x 10(-6) M), blocked PACAP- and VIP-stimulated cAMP accumulation.	Tetradecanoylphorbol Acetate	69-107	adenylate cyclase activating polypeptide 1	Rattus norvegicus	147-152
10082136-7	1999	Furthermore, pretreatment with hydrogen peroxide (H2O2), a potent MAPK activator but inefficient GJC/Cx43 modulator, abrogated PDGF- or TPA-induced disruption of GJC.	Tetradecanoylphorbol Acetate	136-139	gap junction protein alpha 1	Homo sapiens	101-105
8708540-6	1996	Both PACAP- and VIP-stimulated cAMP accumulation were potentiated by 4 beta-phorbol 12-myristate 13-acetate, an activator of protein kinase C. Two PACAP antagonists, PACAP 6-27 (3 x 10(-6) M) and PACAP 6-38 (3 x 10(-6) M), blocked PACAP- and VIP-stimulated cAMP accumulation.	Tetradecanoylphorbol Acetate	69-107	adenylate cyclase activating polypeptide 1	Rattus norvegicus	147-152
8612686-5	1996	Stimulation of hyperproliferation by 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a transient increase of gas2 protein content concomitantly with the time of maximal cell renewal.	Tetradecanoylphorbol Acetate	37-73	growth arrest specific 2	Mus musculus	116-120
7914436-4	1994	The protein kinase C (PKC) activator phorbol myristate acetate (PMA) triggered both IL-3 and IL-5 mRNA expression, whereby IL-5 and IL-3 mRNA expression was observed after 9 and 3 h treatment, respectively.	Tetradecanoylphorbol Acetate	37-62	interleukin 5	Homo sapiens	93-97
7914436-4	1994	The protein kinase C (PKC) activator phorbol myristate acetate (PMA) triggered both IL-3 and IL-5 mRNA expression, whereby IL-5 and IL-3 mRNA expression was observed after 9 and 3 h treatment, respectively.	Tetradecanoylphorbol Acetate	37-62	interleukin 5	Homo sapiens	123-127
7914436-4	1994	The protein kinase C (PKC) activator phorbol myristate acetate (PMA) triggered both IL-3 and IL-5 mRNA expression, whereby IL-5 and IL-3 mRNA expression was observed after 9 and 3 h treatment, respectively.	Tetradecanoylphorbol Acetate	64-67	interleukin 5	Homo sapiens	93-97
7914436-4	1994	The protein kinase C (PKC) activator phorbol myristate acetate (PMA) triggered both IL-3 and IL-5 mRNA expression, whereby IL-5 and IL-3 mRNA expression was observed after 9 and 3 h treatment, respectively.	Tetradecanoylphorbol Acetate	64-67	interleukin 5	Homo sapiens	123-127
8612686-5	1996	Stimulation of hyperproliferation by 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a transient increase of gas2 protein content concomitantly with the time of maximal cell renewal.	Tetradecanoylphorbol Acetate	75-78	growth arrest specific 2	Mus musculus	116-120
10082136-8	1999	While a 5 min H2O2 pretreatment abolished both PDGF- and TPA-induced Cx43 phosphorylation and GJC blockade, a simultaneous H2O2 treatment interfered only with GJC closure but not with the phosphorylation of Cx43 induced by PDGF and TPA.	Tetradecanoylphorbol Acetate	57-60	gap junction protein alpha 1	Homo sapiens	69-73
10082136-8	1999	While a 5 min H2O2 pretreatment abolished both PDGF- and TPA-induced Cx43 phosphorylation and GJC blockade, a simultaneous H2O2 treatment interfered only with GJC closure but not with the phosphorylation of Cx43 induced by PDGF and TPA.	Tetradecanoylphorbol Acetate	57-60	gap junction protein alpha 1	Homo sapiens	207-211
8626531-5	1996	PMA inhibited the histone H1 kinase activity of Cdk2, which increased from about 9 h, whereas PMA did not inhibit the pRb kinase activities of cyclin D-associated kinase(s) and Cdk4, detectable from 0-3 h. These results suggested that the PMA-induced inhibition of pRb phosphorylation is not mediated by suppressing cyclin D-associated kinase(s) including Cdk4, but involves the suppression of Cdk2 activity that results from the reduced expression of cyclins E and A.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase 2	Homo sapiens	48-52
8626533-5	1996	Treatment of adult cardiocytes with either 0.1 microM insulin or 0.1 microM phorbol 12-myristate 13-acetate increased eIF-4E phosphorylation to 23 and 64%, respectively, but these increases were not blocked by 2,3-butanedione monoxime.	Tetradecanoylphorbol Acetate	76-107	eukaryotic translation initiation factor 4E	Canis lupus familiaris	118-124
8167157-6	1994	The release of CCK-LI from STC-1 cells was stimulated by dibutyryl cAMP, forskolin, KCl, A23187, 4 beta-phorbol 12-myristate 13-acetate and luminal stimulants, e.g., sodium oleate, L-tryptophan, camostat and plaunotol.	Tetradecanoylphorbol Acetate	99-135	stanniocalcin 1	Mus musculus	27-32
8149484-4	1994	To determine the effects of overexpression of PKC alpha K and PKC delta K on the AP-1-mediated TPA-inducible genes, we transfected into COS cells the PKC alpha K or PKC delta K expression plasmids with collagenase chloramphenicol acetyltransferase (CAT) reporter construct containing one TPA responsive element (TRE), or a construct containing five synthetic TRE linked to a thymidine kinase promoter.	Tetradecanoylphorbol Acetate	95-98	protein kinase C delta	Homo sapiens	62-71
8149484-8	1994	Overexpression of full-length PKC delta in COS cells also increased the activity of the CAT construct with TRE after TPA treatment.	Tetradecanoylphorbol Acetate	117-120	protein kinase C delta	Homo sapiens	30-39
8149484-10	1994	Cotransfection of PKC alpha K or PKC delta K expression plasmids with a TPA-inducible ODC luc construct (-72/+130-ODC-luc) into HeLa cells resulted in an increased luc activity.	Tetradecanoylphorbol Acetate	72-75	protein kinase C delta	Homo sapiens	33-42
8149484-10	1994	Cotransfection of PKC alpha K or PKC delta K expression plasmids with a TPA-inducible ODC luc construct (-72/+130-ODC-luc) into HeLa cells resulted in an increased luc activity.	Tetradecanoylphorbol Acetate	72-75	ornithine decarboxylase 1	Homo sapiens	86-89
8626548-1	1996	Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells.	Tetradecanoylphorbol Acetate	58-94	Raf-1 proto-oncogene, serine/threonine kinase	Canis lupus familiaris	49-54
8149484-10	1994	Cotransfection of PKC alpha K or PKC delta K expression plasmids with a TPA-inducible ODC luc construct (-72/+130-ODC-luc) into HeLa cells resulted in an increased luc activity.	Tetradecanoylphorbol Acetate	72-75	ornithine decarboxylase 1	Homo sapiens	114-117
10200990-4	1999	METHODS: We measured type I collagen synthesis in murine mesangial cells exposed to estradiol, phorbol 12-myristate 13-acetate (an activator of AP-1), or curcumin (an inhibitor of AP-1).	Tetradecanoylphorbol Acetate	95-126	jun proto-oncogene	Mus musculus	144-148
8149484-11	1994	These results indicate that both PKC alpha (calcium dependent) and PKC delta (calcium independent) may mediate the transcription of TPA-inducible genes through both AP-1 and non-AP-1 sequences.	Tetradecanoylphorbol Acetate	132-135	protein kinase C delta	Homo sapiens	67-76
8018594-4	1994	In contrast, in cells stimulated with phorbol myristate acetate (PMA)/A23187, PGE2 enhanced the production of IL-4 and IL-5, and only partially inhibited the production of other cytokines.	Tetradecanoylphorbol Acetate	38-63	interleukin 5	Homo sapiens	119-123
8018594-4	1994	In contrast, in cells stimulated with phorbol myristate acetate (PMA)/A23187, PGE2 enhanced the production of IL-4 and IL-5, and only partially inhibited the production of other cytokines.	Tetradecanoylphorbol Acetate	65-68	interleukin 5	Homo sapiens	119-123
8071985-9	1994	While TPA treatment induced phosphorylation of connexin43 in these cells, it reduced the expression of connexin45.	Tetradecanoylphorbol Acetate	6-9	gap junction protein alpha 1	Homo sapiens	47-57
8626548-11	1996	RafC did not bind phosphatidyl alcohols; also, inhibition of PA formation in Madin-Darby canine kidney cells by treatment with 1% ethanol significantly reduced the translocation of Raf-1 from the cytosol to the membrane following stimulation with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	247-283	Raf-1 proto-oncogene, serine/threonine kinase	Canis lupus familiaris	181-186
8797807-0	1996	The significance of Ser1029 of the heat-stable enterotoxin receptor (STaR): relation of STa-mediated guanylyl cyclase activation and signaling by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	146-171	guanylate cyclase 2C	Homo sapiens	35-67
10066763-8	1999	Treatment with PKCepsilon antisense oligonucleotides decreased the PMA-induced activation of Na/Pi uptake.	Tetradecanoylphorbol Acetate	67-70	protein kinase C, epsilon	Mus musculus	15-25
8797807-0	1996	The significance of Ser1029 of the heat-stable enterotoxin receptor (STaR): relation of STa-mediated guanylyl cyclase activation and signaling by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	146-171	guanylate cyclase 2C	Homo sapiens	69-73
8642652-10	1996	The observed Raf-1-GABP synergism presumably involves phosphorylation of GABP subunits, as treatment of cells with Raf-1 kinase activators serum and 12-O-tetradecanoylphorbol-13-acetate increases phosphorylation of GABP in vivo.	Tetradecanoylphorbol Acetate	149-185	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	13-18
7914348-4	1994	We find that activation of the second messenger pathway leading from protein kinase C to the transcription factor AP-1 by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) impairs induction of the TAT gene both by glucocorticoid hormones and cAMP.	Tetradecanoylphorbol Acetate	140-177	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	114-118
7914348-4	1994	We find that activation of the second messenger pathway leading from protein kinase C to the transcription factor AP-1 by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) impairs induction of the TAT gene both by glucocorticoid hormones and cAMP.	Tetradecanoylphorbol Acetate	179-182	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	114-118
10193662-4	1999	The orally active chrysotherapeutic agent auranofin, at 3 and 10 microM, inhibited the TPA-stimulated production of prostaglandin E2 and nitric oxide, and suppressed the TPA-induced increase in the levels of mRNA for cyclooxygenase-2 and inducible nitric oxide synthase.	Tetradecanoylphorbol Acetate	87-90	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	217-269
8642652-10	1996	The observed Raf-1-GABP synergism presumably involves phosphorylation of GABP subunits, as treatment of cells with Raf-1 kinase activators serum and 12-O-tetradecanoylphorbol-13-acetate increases phosphorylation of GABP in vivo.	Tetradecanoylphorbol Acetate	149-185	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	115-120
10193662-4	1999	The orally active chrysotherapeutic agent auranofin, at 3 and 10 microM, inhibited the TPA-stimulated production of prostaglandin E2 and nitric oxide, and suppressed the TPA-induced increase in the levels of mRNA for cyclooxygenase-2 and inducible nitric oxide synthase.	Tetradecanoylphorbol Acetate	170-173	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	217-269
8631823-1	1996	The B-lymphoblastoid cell line JY undergoes homotypic aggregation in a lymphocyte function-associated antigen-1 (LFA-1)-mediated, intracellular adhesion molecule-1 (ICAM-1)-dependent manner when stimulated with phorbol 12-myristate 13-acetate or anti-LFA-1 antibodies.	Tetradecanoylphorbol Acetate	211-242	integrin subunit alpha L	Homo sapiens	71-111
8631823-1	1996	The B-lymphoblastoid cell line JY undergoes homotypic aggregation in a lymphocyte function-associated antigen-1 (LFA-1)-mediated, intracellular adhesion molecule-1 (ICAM-1)-dependent manner when stimulated with phorbol 12-myristate 13-acetate or anti-LFA-1 antibodies.	Tetradecanoylphorbol Acetate	211-242	integrin subunit alpha L	Homo sapiens	113-118
8134128-6	1994	In contrast to these two genes the expression of mad was induced upon differentiation in the three cell lines by TPA, retinoic acid, vitamin D3, dimethyl sulfoxide, and interferon-gamma and remained elevated for at least 3 days.	Tetradecanoylphorbol Acetate	113-116	MAX dimerization protein 1	Homo sapiens	49-52
8134128-7	1994	A kinetic analysis showed that the induction of mad in U-937 in response to TPA was rapid (15 min) and at least in part transcriptional, reminiscent of immediate early genes.	Tetradecanoylphorbol Acetate	76-79	MAX dimerization protein 1	Homo sapiens	48-51
8631823-5	1996	p130cas phosphorylation was rapidly reversible upon disengagement of the LFA-1-ICAM-1 complex and required cell adhesion since binding of phorbol 12-myristate 13-acetate-stimulated JY cells to purified ICAM-1 or cross-linking of either LFA-1 or ICAM-1 was not sufficient to induce phosphorylation of p130cas.	Tetradecanoylphorbol Acetate	138-169	integrin subunit alpha L	Homo sapiens	73-78
10193662-5	1999	These findings indicate that the inhibition by auranofin of the TPA-stimulated production of prostaglandin E2 and nitric oxide is due to the decrease in the levels of mRNA for cyclooxygenase-2 and inducible nitric oxide synthase, respectively, and the interaction of the production between prostaglandin E2 and nitric oxide may partly be involved in the mechanism for the inhibition by auranofin of the production of both prostaglandin E2 and nitric oxide.	Tetradecanoylphorbol Acetate	64-67	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	176-228
8631823-5	1996	p130cas phosphorylation was rapidly reversible upon disengagement of the LFA-1-ICAM-1 complex and required cell adhesion since binding of phorbol 12-myristate 13-acetate-stimulated JY cells to purified ICAM-1 or cross-linking of either LFA-1 or ICAM-1 was not sufficient to induce phosphorylation of p130cas.	Tetradecanoylphorbol Acetate	138-169	integrin subunit alpha L	Homo sapiens	236-241
8147862-3	1994	The peptide stimulated Pi uptake dose-dependently at the range of 10(-11)-10(-7) M. Activation of protein kinase C (PKC) by 12-O-Tetradecanoyl phorbol-13-acetate (TPA) also increased Pi uptake in time- and dose-dependent manners similar to PTHrP.	Tetradecanoylphorbol Acetate	124-161	parathyroid hormone like hormone	Homo sapiens	240-245
8147862-6	1994	The PTHrP-induced increase in Pi uptake was strongly inhibited by pretreating cells with PKC inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride (H-7) (50 microM), and by down-regulating PKC with a prolonged TPA pretreatment.	Tetradecanoylphorbol Acetate	231-234	parathyroid hormone like hormone	Homo sapiens	4-9
9873060-1	1999	Previously, we reported that in papilloma-producing 308 mouse keratinocytes, the tumor promoter okadaic acid, a serine-threonine phosphatase inhibitor, increased binding of activator protein 1 (AP-1) to a consensus 12-O-tetradecanoylphorbol-13-acetate-responsive element (Rosenberger, S. F., and Bowden, G. T. (1996) Oncogene 12, 2301-2308).	Tetradecanoylphorbol Acetate	215-251	jun proto-oncogene	Mus musculus	173-192
8186193-6	1994	Of the utmost interest is the finding that a proliferative response to CD28 mAb and phorbol myristate acetate stimulation is exclusively obtained in the CD28+BB27+ cell subset, whereas the CD28+BB27- subset fails to proliferate.	Tetradecanoylphorbol Acetate	84-109	CD28 molecule	Homo sapiens	153-157
8186193-6	1994	Of the utmost interest is the finding that a proliferative response to CD28 mAb and phorbol myristate acetate stimulation is exclusively obtained in the CD28+BB27+ cell subset, whereas the CD28+BB27- subset fails to proliferate.	Tetradecanoylphorbol Acetate	84-109	CD28 molecule	Homo sapiens	153-157
8120094-10	1994	A mutant pIgR in which serines 664 and 726, the major sites of phosphorylation, are replaced by alanine is stimulated to transcytose by PMA, suggesting that phosphorylation of pIgR at these sites is not required for the effect of PMA.	Tetradecanoylphorbol Acetate	136-139	polymeric immunoglobulin receptor	Canis lupus familiaris	9-13
8120094-10	1994	A mutant pIgR in which serines 664 and 726, the major sites of phosphorylation, are replaced by alanine is stimulated to transcytose by PMA, suggesting that phosphorylation of pIgR at these sites is not required for the effect of PMA.	Tetradecanoylphorbol Acetate	136-139	polymeric immunoglobulin receptor	Canis lupus familiaris	176-180
8613198-3	1996	The state of growth arrest by serum deprivation was associated with increased expression of the AT2 receptor, which was markedly suppressed by exposure to the active phorbol ester 12-O-tetradecanoylphorbol 13-acetate and the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	180-216	angiotensin II receptor, type 2	Rattus norvegicus	96-99
9873060-1	1999	Previously, we reported that in papilloma-producing 308 mouse keratinocytes, the tumor promoter okadaic acid, a serine-threonine phosphatase inhibitor, increased binding of activator protein 1 (AP-1) to a consensus 12-O-tetradecanoylphorbol-13-acetate-responsive element (Rosenberger, S. F., and Bowden, G. T. (1996) Oncogene 12, 2301-2308).	Tetradecanoylphorbol Acetate	215-251	jun proto-oncogene	Mus musculus	194-198
8734475-5	1996	Prolonged exposure to TPA reduced the subsequent GH response to TPA equally in neonates and adults, but differentially affected the GH response to GHRH; TPA exposure reduced the GH response to GHRH in neonates, but not in adults.	Tetradecanoylphorbol Acetate	22-25	growth hormone releasing hormone	Rattus norvegicus	147-151
10370867-9	1999	As judged by the reverse transcriptase-polymerase chain reaction, resveratrol selectively inhibited TPA-induced expression of c-fos and transforming growth factor-beta 1 (TGF-beta 1), but did not affect other TPA-induced gene products including COX-1, COX-2, c-myc, c-jun, and tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	100-103	transforming growth factor, beta 1	Mus musculus	136-169
8635483-9	1996	Antisense oligonucleotides to c-fos and c-jun strongly inhibited the induction of stromelysin mRNA in primary cells treated with PMA, but was only weakly active against message induction in HIG-82 cells.	Tetradecanoylphorbol Acetate	129-132	transcription factor Jun	Oryctolagus cuniculus	40-45
7509863-6	1994	Of these three agonists, only TPA stimulated phosphorylation of MARCKS (225% of control), a specific substrate of PKC.	Tetradecanoylphorbol Acetate	30-33	myristoylated alanine rich protein kinase C substrate	Homo sapiens	64-70
10370867-9	1999	As judged by the reverse transcriptase-polymerase chain reaction, resveratrol selectively inhibited TPA-induced expression of c-fos and transforming growth factor-beta 1 (TGF-beta 1), but did not affect other TPA-induced gene products including COX-1, COX-2, c-myc, c-jun, and tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	100-103	transforming growth factor, beta 1	Mus musculus	171-181
8655632-3	1996	In sharp contrast, when cells were first treated with 1 microM TPA at 37 degrees C for 24 h or with 5 microM sphingosine at 37 degrees C for 30 min to down-regulate cellular PKC, the heat induction on kinase FA/GSK-3 alpha was found to be reversely promoted up to approximately 250% of control level, demonstrating that kinase FA/GSK-3 alpha may not represent a constitutively active/mitogen-inactivated protein kinase as previously conceived.	Tetradecanoylphorbol Acetate	63-66	glycogen synthase kinase 3 alpha	Homo sapiens	211-222
8655632-3	1996	In sharp contrast, when cells were first treated with 1 microM TPA at 37 degrees C for 24 h or with 5 microM sphingosine at 37 degrees C for 30 min to down-regulate cellular PKC, the heat induction on kinase FA/GSK-3 alpha was found to be reversely promoted up to approximately 250% of control level, demonstrating that kinase FA/GSK-3 alpha may not represent a constitutively active/mitogen-inactivated protein kinase as previously conceived.	Tetradecanoylphorbol Acetate	63-66	glycogen synthase kinase 3 alpha	Homo sapiens	330-341
10370867-9	1999	As judged by the reverse transcriptase-polymerase chain reaction, resveratrol selectively inhibited TPA-induced expression of c-fos and transforming growth factor-beta 1 (TGF-beta 1), but did not affect other TPA-induced gene products including COX-1, COX-2, c-myc, c-jun, and tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	100-103	cytochrome c oxidase II, mitochondrial	Mus musculus	252-257
8655632-4	1996	Taken together, the results provide initial evidence that TPA/sphingosine and okadaic acid could reversibly modulate the heat induction on kinase FA/GSK-3 alpha in A431 cells, suggesting that phosphorylation/dephosphorylation mechanisms are involved in the regulation of the heat-shock induction of kinase FA/GSK-3 alpha, representing a new mode of signal transduction for the regulation of this multisubstrate protein kinase and a new mode of signaling pathway modulating the heat-induction process.	Tetradecanoylphorbol Acetate	58-61	glycogen synthase kinase 3 alpha	Homo sapiens	149-160
8655632-4	1996	Taken together, the results provide initial evidence that TPA/sphingosine and okadaic acid could reversibly modulate the heat induction on kinase FA/GSK-3 alpha in A431 cells, suggesting that phosphorylation/dephosphorylation mechanisms are involved in the regulation of the heat-shock induction of kinase FA/GSK-3 alpha, representing a new mode of signal transduction for the regulation of this multisubstrate protein kinase and a new mode of signaling pathway modulating the heat-induction process.	Tetradecanoylphorbol Acetate	58-61	glycogen synthase kinase 3 alpha	Homo sapiens	309-320
8206322-6	1994	A significant dose-dependent increase in tPA activity was observed in the GH-treated cells.	Tetradecanoylphorbol Acetate	41-44	gonadotropin releasing hormone receptor	Rattus norvegicus	74-76
8206322-7	1994	This effect was exerted at the mRNA level and the use of cycloheximide, a protein synthesis inhibitor, suggested that GH did not require any other intermediary protein for inducing tPA-mRNA.	Tetradecanoylphorbol Acetate	181-184	gonadotropin releasing hormone receptor	Rattus norvegicus	118-120
10370867-9	1999	As judged by the reverse transcriptase-polymerase chain reaction, resveratrol selectively inhibited TPA-induced expression of c-fos and transforming growth factor-beta 1 (TGF-beta 1), but did not affect other TPA-induced gene products including COX-1, COX-2, c-myc, c-jun, and tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	100-103	jun proto-oncogene	Mus musculus	266-271
8313375-6	1994	Of interest was the finding that 12-O-tetradecanoylphorbol-13-acetate induction of other cellular genes known to be regulated by AP-1 was not inhibited in the benign tumor cells expressing v-jun.	Tetradecanoylphorbol Acetate	33-69	jun proto-oncogene	Mus musculus	129-133
9869604-8	1999	Long-term exposure of cells to phorbol myristate acetate caused the depletion of PKC-delta and -gamma and prevented also IGF-I-induced cell motility.	Tetradecanoylphorbol Acetate	31-56	protein kinase C delta	Homo sapiens	81-101
7507827-10	1994	Similarly, pretreatment with TPA, but not cAMP or Bay K, prevented subsequent stimulation by GnRH.	Tetradecanoylphorbol Acetate	29-32	gonadotropin releasing hormone 1	Homo sapiens	93-97
8780171-0	1996	Activation of human umbilical vein endothelial cell progelatinase A by phorbol myristate acetate: a protein kinase C-dependent mechanism involving a membrane-type matrix metalloproteinase.	Tetradecanoylphorbol Acetate	71-96	matrix metallopeptidase 2	Homo sapiens	52-67
10529599-3	1999	We measured here beta1 and beta2 integrin on eosinophils stimulated by phorbol-12-myristate-13-acetate (PMA)/ionomycin to evaluate eosinophil activation in vitro using whole blood.	Tetradecanoylphorbol Acetate	71-102	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	27-32
8780171-0	1996	Activation of human umbilical vein endothelial cell progelatinase A by phorbol myristate acetate: a protein kinase C-dependent mechanism involving a membrane-type matrix metalloproteinase.	Tetradecanoylphorbol Acetate	71-96	matrix metallopeptidase 14	Homo sapiens	149-187
9857003-2	1998	A peak of elevated PTP activity was detected in whole cell lysates after 15-20 min of treatment of the cells with high KCl, glucose, or TPA, which did not appear upon treatment with control compounds.	Tetradecanoylphorbol Acetate	136-139	protein tyrosine phosphatase receptor type U	Homo sapiens	19-22
8692437-2	1996	The technical efficacy of fibrinolysis, defined as the clot volume lysed per unit time, was found to be optimal with r-tissue plasminogen activator (TPA) activated lys-plasminogen (= plasmin).	Tetradecanoylphorbol Acetate	149-152	plasminogen	Homo sapiens	126-133
9833769-2	1998	In this model, L-10 cells moved as coherent cell sheets when stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA), and we called this type of movement "cohort migration".	Tetradecanoylphorbol Acetate	77-113	ribosomal protein L10	Homo sapiens	15-19
8825421-2	1996	In sharp contrast, down-regulation of PKC by 0.05 microM calphostin C (IC50, approximately 0.05 microM for inhibiting PKC in cells) or by tumor promoter phorbol ester TPA was found to have stimulatory effect on the cellular activity of kinase FA/GSK-3 alpha, when processed under identical conditions.	Tetradecanoylphorbol Acetate	167-170	glycogen synthase kinase 3 alpha	Homo sapiens	246-257
8825422-5	1996	The phorbol ester, phorbol 12-myristate 13-acetate (PMA), produced a transient association of PKC delta with the beta cell cytoskeleton along with sustained decreases in cytosolic enzyme and transient increases in membrane enzyme.	Tetradecanoylphorbol Acetate	19-50	protein kinase C delta	Homo sapiens	94-103
8825422-5	1996	The phorbol ester, phorbol 12-myristate 13-acetate (PMA), produced a transient association of PKC delta with the beta cell cytoskeleton along with sustained decreases in cytosolic enzyme and transient increases in membrane enzyme.	Tetradecanoylphorbol Acetate	52-55	protein kinase C delta	Homo sapiens	94-103
8522995-6	1996	Activation of the ATPase was reversed by phorbol 12-myristate 13-acetate, an activator of protein kinase C, indicating that activation of Na+,K(+)-ATPase is due to decreased phosphorylation by protein kinase C. W-7 or cyclosporin, both inhibitors of calcineurin, prevented the activation of Na+,K(+)-ATPase by glutamate.	Tetradecanoylphorbol Acetate	41-72	dynein axonemal heavy chain 8	Homo sapiens	18-24
8522995-6	1996	Activation of the ATPase was reversed by phorbol 12-myristate 13-acetate, an activator of protein kinase C, indicating that activation of Na+,K(+)-ATPase is due to decreased phosphorylation by protein kinase C. W-7 or cyclosporin, both inhibitors of calcineurin, prevented the activation of Na+,K(+)-ATPase by glutamate.	Tetradecanoylphorbol Acetate	41-72	dynein axonemal heavy chain 8	Homo sapiens	147-153
8522995-6	1996	Activation of the ATPase was reversed by phorbol 12-myristate 13-acetate, an activator of protein kinase C, indicating that activation of Na+,K(+)-ATPase is due to decreased phosphorylation by protein kinase C. W-7 or cyclosporin, both inhibitors of calcineurin, prevented the activation of Na+,K(+)-ATPase by glutamate.	Tetradecanoylphorbol Acetate	41-72	dynein axonemal heavy chain 8	Homo sapiens	147-153
8602120-7	1996	However, a ligand for protein kinase C (PKC), phorbol 12-myristate 13-acetate, was effective in augmenting the action of intrauterine EGF, or forskolin, for initiation of implantation.	Tetradecanoylphorbol Acetate	46-77	epidermal growth factor like 1	Rattus norvegicus	134-137
12237684-1	1996	The change of GnT III activity paralleled that of membranous PKC (m-PKC) when the cells were treated with PMA, but not with that of cytosolic PKC (c-PKC).	Tetradecanoylphorbol Acetate	106-109	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	14-21
8618876-5	1995	PTP epsilon-cytoplasmic mRNA is the product of a delayed early response gene in NIH 3T3 fibroblasts, and its transcription is regulated through a pathway that requires protein kinase C. The human homologue of PTP epsilon-cytoplasmic has also been cloned and is strongly up-regulated in the early stages of phorbol 12-tetradecanoate 13-acetate-induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	306-342	protein tyrosine phosphatase receptor type U	Homo sapiens	0-3
8618876-5	1995	PTP epsilon-cytoplasmic mRNA is the product of a delayed early response gene in NIH 3T3 fibroblasts, and its transcription is regulated through a pathway that requires protein kinase C. The human homologue of PTP epsilon-cytoplasmic has also been cloned and is strongly up-regulated in the early stages of phorbol 12-tetradecanoate 13-acetate-induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	306-342	protein tyrosine phosphatase receptor type U	Homo sapiens	209-212
8848234-1	1995	We examined age-related changes in composition of transcription factor, activator protein-1 (AP-1) which binds to TPA responsive element (TRE) in the non-stimulated rat brain, using electrophoretic mobility-shift assay with immunodepletion/supershift assay.	Tetradecanoylphorbol Acetate	114-117	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	72-91
8848234-1	1995	We examined age-related changes in composition of transcription factor, activator protein-1 (AP-1) which binds to TPA responsive element (TRE) in the non-stimulated rat brain, using electrophoretic mobility-shift assay with immunodepletion/supershift assay.	Tetradecanoylphorbol Acetate	114-117	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	93-97
8632663-4	1995	Consistent with these findings, MC3 cells treated with TPA showed an increased expression of GATA-1, but not GATA-3 transcripts, whereas those without TPA treatment expressed only the GATA-2 transcript.	Tetradecanoylphorbol Acetate	55-58	GATA binding protein 2	Homo sapiens	184-190
8521972-3	1995	After treatment with phorbol myristate acetate (PMA), only the Fc gamma RIIa molecules capable of mediating rapid endocytosis of immune complexes exhibited a reduced lateral diffusion coefficient with respect to untreated controls.	Tetradecanoylphorbol Acetate	21-46	Fc gamma receptor IIa	Homo sapiens	63-76
8521972-3	1995	After treatment with phorbol myristate acetate (PMA), only the Fc gamma RIIa molecules capable of mediating rapid endocytosis of immune complexes exhibited a reduced lateral diffusion coefficient with respect to untreated controls.	Tetradecanoylphorbol Acetate	48-51	Fc gamma receptor IIa	Homo sapiens	63-76
7478524-4	1995	Unlike known TPA-resistant cells whose resistance is mainly due to lack or down modulation of protein kinase C (PKC), UT16 cells showed TPA-induced activation of PKC, Raf-1, and ERK/MAP kinases similar to the parental U937 cells.	Tetradecanoylphorbol Acetate	136-139	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	167-172
7478524-7	1995	Among UT16 cells, most of TPA-inducible PTPase genes, PTP-1C, PTP-MEG2, P19-PTP, HPTP epsilon, and PTP-U1, did not respond to TPA.	Tetradecanoylphorbol Acetate	26-29	protein tyrosine phosphatase receptor type D	Homo sapiens	81-85
7594459-3	1995	These activated T cells produced IL-2, IL-4, IL-5, and IFN-gamma upon stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	87-90	interleukin 5	Homo sapiens	45-49
7576692-7	1995	CGRP secretion was stimulated in a concentration-dependent fashion by phorbol myristate acetate, but it was not affected by forskolin, capsaicin, bradykinin, or nicotine.	Tetradecanoylphorbol Acetate	70-95	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
8589651-6	1995	The increases in GLUT-1 mRNA level in response to vanadate and TPA were paralleled bh much smaller increases in immunoreactive GLUT-1 protein level, whereas okadaic acid treatment markedly elevated GLUT-1 protein without a concomitant change in GLUT-1 mRNA levels.	Tetradecanoylphorbol Acetate	63-66	solute carrier family 2 member 1	Rattus norvegicus	17-23
7585518-8	1995	ET-18-OCH3 markedly inhibits TPA-induced NF-kappa B activation, as measured by HIV long terminal repeat-directed expression of beta-galactosidase.	Tetradecanoylphorbol Acetate	29-32	galactosidase beta 1	Homo sapiens	127-145
7588214-4	1995	We found that PMA-stimulated DNA synthesis was associated with increments in tyrosine phosphorylation of p44mapk (ERK1) and p42mapk (ERK2) and activation of Raf-1, MKK, and MAPK in these cells.	Tetradecanoylphorbol Acetate	14-17	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	157-162
7589260-0	1995	Inhibition of the melanoma cell cycle and regulation at the G1/S transition by 12-O-tetradecanoylphorbol-13-acetate (TPA) by modulation of CDK2 activity.	Tetradecanoylphorbol Acetate	79-115	cyclin dependent kinase 2	Homo sapiens	139-143
7589260-0	1995	Inhibition of the melanoma cell cycle and regulation at the G1/S transition by 12-O-tetradecanoylphorbol-13-acetate (TPA) by modulation of CDK2 activity.	Tetradecanoylphorbol Acetate	117-120	cyclin dependent kinase 2	Homo sapiens	139-143
7589260-3	1995	To investigate the mechanism by which TPA arrests melanoma cell growth at the G1/S transition we have examined its effects on the levels of cyclins and cyclin dependent kinases (CDKs) and activation of CDK2 kinase activity.	Tetradecanoylphorbol Acetate	38-41	cyclin dependent kinase 2	Homo sapiens	202-206
7589260-5	1995	When TPA was added in G1, it inhibited the mobility shift of CDK2 reflecting a change in phosphorylation state.	Tetradecanoylphorbol Acetate	5-8	cyclin dependent kinase 2	Homo sapiens	61-65
7589260-8	1995	Treatment with TPA during G1 caused a three to four fold increase in cyclin D1 mRNA expression, but blocked the increase in the expression of cyclin A and cyclin B mRNAs later in the cell cycle.	Tetradecanoylphorbol Acetate	15-18	cyclin D1	Homo sapiens	69-78
7559616-9	1995	In the present experiments calmodulin prevented MARCKS phosphorylation by TPA-stimulated PKCs in glioma cell lysates, and this blockade was lifted by a calmodulin antagonist, the calmodulin-binding domain peptide.	Tetradecanoylphorbol Acetate	74-77	calmodulin 1	Rattus norvegicus	27-37
7559616-9	1995	In the present experiments calmodulin prevented MARCKS phosphorylation by TPA-stimulated PKCs in glioma cell lysates, and this blockade was lifted by a calmodulin antagonist, the calmodulin-binding domain peptide.	Tetradecanoylphorbol Acetate	74-77	calmodulin 1	Rattus norvegicus	152-162
7559616-9	1995	In the present experiments calmodulin prevented MARCKS phosphorylation by TPA-stimulated PKCs in glioma cell lysates, and this blockade was lifted by a calmodulin antagonist, the calmodulin-binding domain peptide.	Tetradecanoylphorbol Acetate	74-77	calmodulin 1	Rattus norvegicus	152-162
7951545-4	1994	Immunoblot analysis of PKC during treatment with ACTH or TPA showed that PKC beta translocated from cytosol to membrane.	Tetradecanoylphorbol Acetate	57-60	protein kinase C beta	Homo sapiens	73-81
7951545-6	1994	It appeared that TPA-induced cortisol secretion mimicked ACTH-induced cortisol secretion, and that PKC beta translocated from cytosol to membrane on stimulation by both ACTH and TPA.	Tetradecanoylphorbol Acetate	178-181	protein kinase C beta	Homo sapiens	99-107
8113389-3	1994	A 4.5-kb mRNA, which hybridizes to the mouse cyclooxygenase-2 cDNA probe, is elevated 18-fold within 30 min after TGF alpha or TPA treatment.	Tetradecanoylphorbol Acetate	127-130	prostaglandin-endoperoxide synthase 2	Mus musculus	45-61
7508390-7	1994	Phorbol 12-myristate 13-acetate had an inhibitory effect on brush-border enzyme synthesis, in particular on sucrase-isomaltase, and blocked the forskolin-induced biosynthesis of lactase-phlorizin hydrolase.	Tetradecanoylphorbol Acetate	0-31	lactase	Homo sapiens	178-205
8286746-2	1994	An HL-60 variant cell line, termed HL-525, derived from long-term exposure to TPA (Homma et al, Proc Natl Acad Sci USA 83: 7316, 1986) is resistant to TPA-induced differentiation and displays decreased PKC beta expression compared with the HL-60 parent line.	Tetradecanoylphorbol Acetate	78-81	protein kinase C beta	Homo sapiens	202-210
8286746-4	1994	Whereas treatment of HL-525 cells with ATRA or TPA alone had no effect on features of monocytic differentiation, these agents in combination resulted in cellular adhesion, nonspecific esterase staining, and induction of the c-fms (monocyte growth factor receptor) gene.	Tetradecanoylphorbol Acetate	47-50	colony stimulating factor 1 receptor	Homo sapiens	224-229
9833769-2	1998	In this model, L-10 cells moved as coherent cell sheets when stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA), and we called this type of movement "cohort migration".	Tetradecanoylphorbol Acetate	115-118	ribosomal protein L10	Homo sapiens	15-19
8314307-4	1994	Immunoblotting experiments revealed that in parental SK-Mel 173 cells PKC beta was rapidly down-regulated to below detectable levels after treatment for 48 hr with TPA, but that in TPA-resistant variant clones there was negligible down-regulation of PKC beta by TPA.	Tetradecanoylphorbol Acetate	164-167	protein kinase C beta	Homo sapiens	70-78
9833769-7	1998	In this HGF/SF-induced migration, localized release from cell-cell adhesion was induced only at the lower portion of the cells, allowing them to extend leading lamellae, whereas close cell-cell contacts remained at the upper portion of the cells, as seen in TPA-induced cohort migration.	Tetradecanoylphorbol Acetate	258-261	hepatocyte growth factor	Homo sapiens	8-14
9837861-8	1998	Since TPA induces differentiation in human breast cancer cells and up-regulates MnSOD gene in HeLa cells, MnSOD expression and AP-1 and NF-kappaB activity were measured under TPA treatment.	Tetradecanoylphorbol Acetate	6-9	superoxide dismutase 2	Homo sapiens	80-85
8288641-1	1994	Treatment of human myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C (PKC), is associated with induction of monocytic differentiation.	Tetradecanoylphorbol Acetate	47-83	protein kinase C beta	Homo sapiens	125-128
9837861-9	1998	The results showed that TPA induced endogenous MnSOD expression and inhibited both AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	24-27	superoxide dismutase 2	Homo sapiens	47-52
8288641-1	1994	Treatment of human myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C (PKC), is associated with induction of monocytic differentiation.	Tetradecanoylphorbol Acetate	85-88	protein kinase C beta	Homo sapiens	125-128
8288641-3	1994	The results demonstrate that Raf-1 is activated during TPA-induced monocytic differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	55-58	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	29-34
8288641-7	1994	Treatment of HL-60, but not HL-525, cells with TPA was associated with increased MAP kinase activity as determined by phosphorylation of myelin basic protein and the c-Jun Y peptide.	Tetradecanoylphorbol Acetate	47-50	myelin basic protein	Homo sapiens	137-157
8288641-11	1994	The results also demonstrate that retinoic acid-treated HL-525 cells respond to TPA with activation of Raf-1 and MAP kinase, as well as induction of monocytic differentiation.	Tetradecanoylphorbol Acetate	80-83	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	103-108
8288641-12	1994	Taken together, the results indicate that activation of Raf-1/MAP kinase signaling is associated with monocytic differentiation and that stimulation of serine/threonine protein phosphorylation by TPA or okadaic acid is sufficient for reversal of the leukemic HL-60 phenotype.	Tetradecanoylphorbol Acetate	196-199	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	56-61
9824772-3	1998	We report that T-lymphocytes up-regulate the expression of occludin, a major component of the tight junction in response to stimulation with phorbol ester (PMA) + calcium ionophore, CD3 antibody or T-cell receptor (TCR) antibody.	Tetradecanoylphorbol Acetate	156-159	occludin	Homo sapiens	59-67
7913331-9	1994	Moreover, class II costimulation potentiated CD28-mAb-induced T cell sensitivity to protein kinase C activation by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	115-146	CD28 molecule	Homo sapiens	45-49
9808756-6	1998	Phosphorylation of MARCKS was increased about eightfold by the treatment of the cells with phorbol 12-myristate 13-acetate, a protein kinase C activator.	Tetradecanoylphorbol Acetate	91-122	myristoylated alanine rich protein kinase C substrate	Homo sapiens	19-25
8283142-10	1994	By contrast, TPA treatment resulted in a twofold decrease of CD14 cell surface staining with no significant change in sCD14, while CD14 mRNA was transiently down-regulated.	Tetradecanoylphorbol Acetate	13-16	CD14 molecule	Homo sapiens	61-65
9804846-9	1998	Cells transfected with a PKCdelta mutant (PKCdelta5), in which the five putative tyrosine phosphorylation sites were mutated to phenylalanine, showed markedly diminished tyrosine phosphorylation in response to phorbol 12-myristate 13-acetate and platelet-derived growth factor and normal levels of GS.	Tetradecanoylphorbol Acetate	210-241	protein kinase C delta	Homo sapiens	25-33
7507197-6	1994	TPA, AZA and DAG decreased desmin in the cytoplasmic and cytoskeletal fractions.	Tetradecanoylphorbol Acetate	0-3	desmin	Gallus gallus	27-33
9804854-4	1998	alpha-ENaC down-regulation could also be seen in cells treated with 12-O-tetradecanoyl-1-phorbol-13-acetate (TPA), indicating that the repression of steady-state alpha-ENaC mRNA level was dependent upon the activity of protein kinase C, the target of TPA, as well.	Tetradecanoylphorbol Acetate	109-112	sodium channel epithelial 1 subunit alpha	Rattus norvegicus	0-10
7512195-2	1994	Activation of PKC by 12-O-tetradecanoylphorbol-13-acetate in the CHO-PKC alpha cells inhibited by approximately 75% the: 1) insulin-stimulated increase in antiphosphotyrosine precipitable phosphatidylinositol 3-kinase activity in these cells; 2) insulin-stimulated increase in PI 3-kinase activity associated with insulin receptor substrate-1; and 3) tyrosine phosphorylation of the endogenous substrate, insulin receptor substrate-1.	Tetradecanoylphorbol Acetate	21-57	insulin receptor substrate 1	Cricetulus griseus	405-433
8264601-11	1994	Together, these results indicate that the TPA response in Drosophila cells stimulates specific transcription of RNA polymerase III genes by increasing the activity of the limiting transcription component, TFIIIB, and thereby increasing the number of functional transcription complexes.	Tetradecanoylphorbol Acetate	42-45	RNA polymerase III 128kD subunit	Drosophila melanogaster	112-130
9804854-4	1998	alpha-ENaC down-regulation could also be seen in cells treated with 12-O-tetradecanoyl-1-phorbol-13-acetate (TPA), indicating that the repression of steady-state alpha-ENaC mRNA level was dependent upon the activity of protein kinase C, the target of TPA, as well.	Tetradecanoylphorbol Acetate	109-112	sodium channel epithelial 1 subunit alpha	Rattus norvegicus	162-172
8165623-3	1993	93% of the uPA and 17% of the tPA antigen in seminal plasma was in complex with PCI and, when complexation was inhibited by collecting semen into an 1,10-phenanthrolinium solution, 33% of the uPA and 7% of the tPA was complexed to PCI.	Tetradecanoylphorbol Acetate	30-33	serpin family A member 5	Homo sapiens	80-83
9804854-4	1998	alpha-ENaC down-regulation could also be seen in cells treated with 12-O-tetradecanoyl-1-phorbol-13-acetate (TPA), indicating that the repression of steady-state alpha-ENaC mRNA level was dependent upon the activity of protein kinase C, the target of TPA, as well.	Tetradecanoylphorbol Acetate	251-254	sodium channel epithelial 1 subunit alpha	Rattus norvegicus	0-10
8165623-5	1993	In purified system, complexation of uPA and tPA to PCI paralleled the inhibition of the enzymes.	Tetradecanoylphorbol Acetate	44-47	serpin family A member 5	Homo sapiens	51-54
9804854-4	1998	alpha-ENaC down-regulation could also be seen in cells treated with 12-O-tetradecanoyl-1-phorbol-13-acetate (TPA), indicating that the repression of steady-state alpha-ENaC mRNA level was dependent upon the activity of protein kinase C, the target of TPA, as well.	Tetradecanoylphorbol Acetate	251-254	sodium channel epithelial 1 subunit alpha	Rattus norvegicus	162-172
8165623-6	1993	In vitro studies in blood and seminal plasma showed that heparin stimulated complexation of uPA and tPA with PCI, suggesting that negatively charged glycosaminoglycans in blood vessels and in the reproductive system may regulate PCI reactions with uPA and tPA.	Tetradecanoylphorbol Acetate	100-103	serpin family A member 5	Homo sapiens	109-112
7559616-10	1995	But, physiologically more significant, pretreating intact glioma cells with a cell-permeable calmodulin antagonist, calmidazolium, prevented ionomycin from blocking MARCKS phosphorylation by PKCs in unstimulated and TPA-stimulated cells.	Tetradecanoylphorbol Acetate	216-219	calmodulin 1	Rattus norvegicus	93-103
8165623-6	1993	In vitro studies in blood and seminal plasma showed that heparin stimulated complexation of uPA and tPA with PCI, suggesting that negatively charged glycosaminoglycans in blood vessels and in the reproductive system may regulate PCI reactions with uPA and tPA.	Tetradecanoylphorbol Acetate	100-103	serpin family A member 5	Homo sapiens	229-232
7559663-12	1995	The effects of TPA appear to be mediated by activation of protein kinase C since the protein kinase C inhibitors, H-7 and bryostatin, block the effects of TPA on estradiol induction of progesterone receptor.	Tetradecanoylphorbol Acetate	15-18	progesterone receptor	Homo sapiens	185-206
9804854-5	1998	Pretreatment of cells with a specific inhibitor of the ERK kinase pathway, PD 98059, markedly abolished the down-regulation of alpha-ENaC expression, consistent with the hypothesis that the ERK kinase-signaling pathway is involved in TPA-mediated repression.	Tetradecanoylphorbol Acetate	234-237	sodium channel epithelial 1 subunit alpha	Rattus norvegicus	127-137
7559663-12	1995	The effects of TPA appear to be mediated by activation of protein kinase C since the protein kinase C inhibitors, H-7 and bryostatin, block the effects of TPA on estradiol induction of progesterone receptor.	Tetradecanoylphorbol Acetate	155-158	progesterone receptor	Homo sapiens	185-206
8165623-6	1993	In vitro studies in blood and seminal plasma showed that heparin stimulated complexation of uPA and tPA with PCI, suggesting that negatively charged glycosaminoglycans in blood vessels and in the reproductive system may regulate PCI reactions with uPA and tPA.	Tetradecanoylphorbol Acetate	256-259	serpin family A member 5	Homo sapiens	109-112
8165623-7	1993	These results suggest that PCI is a physiologic regulator of uPA and tPA in male reproductive tissues and raises questions about a potential role of PCI in human fertility and in uPA-dependent cell invasiveness.	Tetradecanoylphorbol Acetate	69-72	serpin family A member 5	Homo sapiens	27-30
9788877-6	1998	Furthermore, the potentiating effect of TPA on the heat-induced stress response requires an intact heat shock element in the hsp70 promoter, indicating that PKC-responsive pathways are able to modulate the activity of HSF1.	Tetradecanoylphorbol Acetate	40-43	heat shock transcription factor 1	Homo sapiens	218-222
8245000-6	1993	PGHS-2 mRNA was induced at 2 h in serum-free cells by transforming growth factor-beta (TGF-beta), phorbol 12-myristate 13-acetate, and, to a lesser extent, by forskolin.	Tetradecanoylphorbol Acetate	98-129	prostaglandin-endoperoxide synthase 2	Mus musculus	0-6
8257426-2	1993	Evidence has been accumulated that in phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, the translocation to the plasma membrane of the cytosolic components p47phox and p67phox and the phosphorylation of p47phox are essential steps in activation of NADPH oxidase.	Tetradecanoylphorbol Acetate	38-69	neutrophil cytosolic factor 2	Homo sapiens	181-188
7552526-2	1995	Available plasmin, required for MMP zymogen activation, is regulated by plasminogen activators (uPA, tPA) and plasminogen activator inhibitors (PAI-1, PAI-2).	Tetradecanoylphorbol Acetate	101-104	plasminogen	Homo sapiens	10-17
7665567-5	1995	Transient expression of CD69 promoter-based reporter gene constructs in K562 cells indicated that the proximal promoter region spanning positions -78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate-inducible transcription of the CD69 gene.	Tetradecanoylphorbol Acetate	216-247	CD69 molecule	Homo sapiens	24-28
7665567-5	1995	Transient expression of CD69 promoter-based reporter gene constructs in K562 cells indicated that the proximal promoter region spanning positions -78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate-inducible transcription of the CD69 gene.	Tetradecanoylphorbol Acetate	216-247	CD69 molecule	Homo sapiens	279-283
9756942-3	1998	B cell activators such as phorbol 12-myristate 13-acetate and lipopolysaccharide (LPS) up-regulate both concentrative transport systems but down-regulate the equilibrative es-type transporter, which correlates with lower hENT1 mRNA levels.	Tetradecanoylphorbol Acetate	26-57	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	221-226
8114616-12	1993	Amphetamine (10 microM) significantly increased phosphorylation of a 53 kDa band that migrated with authentic neuromodulin in the synaptosomes by 22% while 500 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) increased neuromodulin phosphorylation by 45%.	Tetradecanoylphorbol Acetate	163-199	growth associated protein 43	Rattus norvegicus	216-228
8258145-6	1993	H47 mAb also enhanced PMA-induced interleukin-2 receptor (IL-2R) expression and IL-2 synthesis, but did not induce a change in intracellular free calcium ([Ca2+]i) of T cells.	Tetradecanoylphorbol Acetate	22-25	interleukin 2 receptor subunit alpha	Homo sapiens	34-56
9796636-9	1998	In addition to the biological markers of TPA-induced ODC activity in skin biopsies and urinary polyamine levels, we measured urinary 11-dehydrothromboxane B2, a specific metabolite of thromboxane A2.	Tetradecanoylphorbol Acetate	41-44	ornithine decarboxylase 1	Homo sapiens	53-56
8258145-6	1993	H47 mAb also enhanced PMA-induced interleukin-2 receptor (IL-2R) expression and IL-2 synthesis, but did not induce a change in intracellular free calcium ([Ca2+]i) of T cells.	Tetradecanoylphorbol Acetate	22-25	interleukin 2 receptor subunit alpha	Homo sapiens	58-63
8258334-8	1993	The involvement of PKC was confirmed by the observations that phorbol 12-myristate 13-acetate (PMA), a direct activator of PKC, induced the expression of the monokine mRNA and that SEB evoked the activation of membrane-associated PKC.	Tetradecanoylphorbol Acetate	62-93	SET binding protein 1	Homo sapiens	181-184
8258334-8	1993	The involvement of PKC was confirmed by the observations that phorbol 12-myristate 13-acetate (PMA), a direct activator of PKC, induced the expression of the monokine mRNA and that SEB evoked the activation of membrane-associated PKC.	Tetradecanoylphorbol Acetate	95-98	SET binding protein 1	Homo sapiens	181-184
7545713-12	1995	However, IL-13 also directly inhibited monokine secretion, because it blocked PMA-induced, CD14-independent TNF-alpha release.	Tetradecanoylphorbol Acetate	78-81	CD14 molecule	Homo sapiens	91-95
9796636-15	1998	Comparing the 6-month measurements with pretreatment, DFMO/PXM or DFMO significantly reduced TPA-induced ODC levels (Ps, 0.03 and 0.05).	Tetradecanoylphorbol Acetate	93-96	ornithine decarboxylase 1	Homo sapiens	105-108
7553596-2	1995	The c-Fos protein is inducible by TPA and thus is associated with c-Jun to result in an increased AP-1 activity in mouse fibroblast cells.	Tetradecanoylphorbol Acetate	34-37	jun proto-oncogene	Mus musculus	66-71
8119663-6	1993	Pretreatment with 10(-6) M phorbol 12-myristate 13-acetate, which downregulated PKC, significantly blocked the inhibition of DNA synthesis by PTHrP.	Tetradecanoylphorbol Acetate	27-58	parathyroid hormone like hormone	Homo sapiens	142-147
9738001-6	1998	The further expression of IRS-1 in 3Y1-GLUT4myc-IR cells led to stimulation of glycogen synthesis but not to glucose uptake or GLUT4myc translocation in response to insulin, although NaF or phorbol 12-myristate 13-acetate did trigger GLUT4myc translocation in the cells.	Tetradecanoylphorbol Acetate	190-221	insulin receptor	Rattus norvegicus	26-28
7500834-7	1995	The treatment of cells with either NGF or bFGF resulted in a higher degree of stimulation in the basal level of promoter activity than when cells were treated with either PMA, IL-1 or RA.	Tetradecanoylphorbol Acetate	171-174	fibroblast growth factor 2	Rattus norvegicus	42-46
8253856-3	1993	Measurements of M phi pHi and superoxide (O2-) production in response to stimulation with 12-O-tetradecanoyl phorbol 13-acetate (TPA) were made at physiological or acidic extracellular pH (pHo) levels.	Tetradecanoylphorbol Acetate	90-127	glucose-6-phosphate isomerase 1	Mus musculus	18-21
9791726-3	1998	In the present study it is shown that 12-O-tetradecanoylphorbol-13-acetate (TPA) and EGF induce similar phosphorylation pattern of the gap junction protein connexin43 (Cx43) in K7 cells, although their effects on GJIC are opposite.	Tetradecanoylphorbol Acetate	38-74	gap junction protein alpha 1	Homo sapiens	156-166
8224186-6	1993	While PMA-induced growth arrest occurs in L-2 cells which possess PKC alpha and zeta, PMA-induced growth arrest does not occur in L-2/PMA which is deficient in these isoforms.	Tetradecanoylphorbol Acetate	6-9	immunoglobulin kappa variable 3-15	Homo sapiens	42-45
7559765-4	1995	By labeling surface-exposed pIgR in live neuronal cells, we now show (a) internalization of the receptor from the dendritic plasma membrane to the dendritic early endosomes, (b) redistribution of the receptor from the dendritic to the axonal domain, (c) inhibition of this movement by brefeldin A (BFA) and (d) stimulation by the activation of protein kinase C (PKC) via phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	371-396	polymeric immunoglobulin receptor	Canis lupus familiaris	28-32
7559765-4	1995	By labeling surface-exposed pIgR in live neuronal cells, we now show (a) internalization of the receptor from the dendritic plasma membrane to the dendritic early endosomes, (b) redistribution of the receptor from the dendritic to the axonal domain, (c) inhibition of this movement by brefeldin A (BFA) and (d) stimulation by the activation of protein kinase C (PKC) via phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	398-401	polymeric immunoglobulin receptor	Canis lupus familiaris	28-32
7480087-1	1995	Epidermal growth factor (EGF) as well as phorbol 12-myristate 13-acetate (TPA) stimulate de novo synthesis of PGHS (prostaglandin H synthase)-1 and PGHS-2 mRNA, resulting in increased production of PGE2 in rat tracheal epithelial cells (RTE, EGV-6 cells).	Tetradecanoylphorbol Acetate	74-77	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	148-154
8114760-6	1993	phorbol-12-myristate-13-acetate closely mimics these inductive effects of ACTH.	Tetradecanoylphorbol Acetate	0-31	pro-opiomelanocortin-alpha	Mus musculus	74-78
9791726-3	1998	In the present study it is shown that 12-O-tetradecanoylphorbol-13-acetate (TPA) and EGF induce similar phosphorylation pattern of the gap junction protein connexin43 (Cx43) in K7 cells, although their effects on GJIC are opposite.	Tetradecanoylphorbol Acetate	38-74	gap junction protein alpha 1	Homo sapiens	168-172
7642554-2	1995	Within minutes of phorbol 12-myristate 13-acetate treatment, epidermal growth factor receptor and HER2 tyrosine phosphorylation was decreased, while platelet-derived growth factor receptor and insulin receptor autophosphorylation was upregulated.	Tetradecanoylphorbol Acetate	18-49	insulin receptor	Mus musculus	193-209
7593331-2	1995	To characterize in more detail the relationships between kinase activity and junction organization, we have studied the effects of the protein kinase C agonist phorbol myristate acetate (PMA) on the intracellular localization of cingulin, E-cadherin, desmoplakin and actin microfilaments in confluent MDCK monolayers.	Tetradecanoylphorbol Acetate	160-185	cingulin	Canis lupus familiaris	229-237
8405436-4	1993	Exposure of the cells to 100 nM TPA for 10 min resulted in the translocation of conventional PKC alpha (cPKC alpha) and new PKC delta (nPKC delta) and -epsilon from the cytosolic to the membrane fraction, while left atypical PKC zeta (aPKC zeta) unaffected.	Tetradecanoylphorbol Acetate	32-35	protein kinase C delta	Homo sapiens	124-159
8405436-7	1993	After treatment of the cells with 1 microM TPA for 17 h, cPKC alpha, nPKC delta and nPKC epsilon were almost completely down-regulated, whereas aPKC zeta was still unaffected.	Tetradecanoylphorbol Acetate	43-46	protein kinase C delta	Homo sapiens	69-79
9791726-3	1998	In the present study it is shown that 12-O-tetradecanoylphorbol-13-acetate (TPA) and EGF induce similar phosphorylation pattern of the gap junction protein connexin43 (Cx43) in K7 cells, although their effects on GJIC are opposite.	Tetradecanoylphorbol Acetate	76-79	gap junction protein alpha 1	Homo sapiens	156-166
9791726-3	1998	In the present study it is shown that 12-O-tetradecanoylphorbol-13-acetate (TPA) and EGF induce similar phosphorylation pattern of the gap junction protein connexin43 (Cx43) in K7 cells, although their effects on GJIC are opposite.	Tetradecanoylphorbol Acetate	76-79	gap junction protein alpha 1	Homo sapiens	168-172
8238402-2	1993	The Mn-SOD in human endothelial cells was markedly induced by the cytokines tumor necrosis factor (TNF), interleukin-1, and lipopolysaccharide as well as by phorbol esters [12-O-tetradecanoylphorbol 13-acetate (TPA)].	Tetradecanoylphorbol Acetate	173-209	superoxide dismutase 2	Homo sapiens	4-10
8238402-2	1993	The Mn-SOD in human endothelial cells was markedly induced by the cytokines tumor necrosis factor (TNF), interleukin-1, and lipopolysaccharide as well as by phorbol esters [12-O-tetradecanoylphorbol 13-acetate (TPA)].	Tetradecanoylphorbol Acetate	211-214	superoxide dismutase 2	Homo sapiens	4-10
9785042-4	1998	The secretion of hCG is activated by the PKC-activator TPA.	Tetradecanoylphorbol Acetate	55-58	hypertrichosis 2 (generalised, congenital)	Homo sapiens	17-20
8413215-10	1993	Antisense oligonucleotides to RelA, but not NFKB1, inhibited phorbol myristate acetate-induced IL-8 production in Jurkat T lymphocytes.	Tetradecanoylphorbol Acetate	61-86	RELA proto-oncogene, NF-kB subunit	Homo sapiens	30-34
8413220-4	1993	The region downstream of -363 is critical for basal and phorbol myristate acetate-inducible IL-2R beta promoter activity and contains at least three enhancer-like regions.	Tetradecanoylphorbol Acetate	56-81	interleukin 2 receptor subunit beta	Homo sapiens	92-102
8413220-8	1993	We conclude that this Ets binding site plays a key role in regulating basal and phorbol myristate acetate-inducible IL-2R beta promoter activity and may also contribute to tissue-specific expression of the IL-2R beta gene.	Tetradecanoylphorbol Acetate	80-105	interleukin 2 receptor subunit beta	Homo sapiens	116-126
8413220-8	1993	We conclude that this Ets binding site plays a key role in regulating basal and phorbol myristate acetate-inducible IL-2R beta promoter activity and may also contribute to tissue-specific expression of the IL-2R beta gene.	Tetradecanoylphorbol Acetate	80-105	interleukin 2 receptor subunit beta	Homo sapiens	206-216
8413223-2	1993	Probes representing the -300 region or the NF-kappa B site alone interacted with NF-kappa B proteins present in phorbol myristate acetate-, lipopolysaccharide-, or Sendai virus-induced myeloid cell extracts as well as recombinant NFKB1 (p50) and RelA (p65); furthermore, NF-kappa B protein-DNA complex formation was dissociated in vitro by the addition of recombinant I kappa B alpha.	Tetradecanoylphorbol Acetate	112-137	RELA proto-oncogene, NF-kB subunit	Homo sapiens	246-250
8413223-2	1993	Probes representing the -300 region or the NF-kappa B site alone interacted with NF-kappa B proteins present in phorbol myristate acetate-, lipopolysaccharide-, or Sendai virus-induced myeloid cell extracts as well as recombinant NFKB1 (p50) and RelA (p65); furthermore, NF-kappa B protein-DNA complex formation was dissociated in vitro by the addition of recombinant I kappa B alpha.	Tetradecanoylphorbol Acetate	112-137	RELA proto-oncogene, NF-kB subunit	Homo sapiens	252-255
9785042-5	1998	TPA induces hCG release into the medium, thus causing a decrease in intracellular hCG content.	Tetradecanoylphorbol Acetate	0-3	hypertrichosis 2 (generalised, congenital)	Homo sapiens	12-15
9785042-5	1998	TPA induces hCG release into the medium, thus causing a decrease in intracellular hCG content.	Tetradecanoylphorbol Acetate	0-3	hypertrichosis 2 (generalised, congenital)	Homo sapiens	82-85
9706865-0	1998	12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	0-36	aryl hydrocarbon receptor	Homo sapiens	53-64
8214084-3	1993	When PMN were coincubated with PMA (10 ng/ml) for 4 h in Earle"s salt solution, endothelial ACE activity was decreased by 87%.	Tetradecanoylphorbol Acetate	31-34	angiotensin I converting enzyme	Bos taurus	92-95
9706865-0	1998	12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	0-36	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	91-97
7604037-8	1995	In addition, both the tumor promoter okadaic acid (which inhibits protein phosphatases 1 and 2A) and phorbol ester (phorbol 12-tetradecanoate 13-acetate) stimulate phosphorylation of p33, p54, and low molecular mass histones.	Tetradecanoylphorbol Acetate	116-152	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	188-191
8362987-0	1993	Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA.	Tetradecanoylphorbol Acetate	77-80	hepatocyte growth factor	Homo sapiens	14-38
9706014-10	1998	The effects of TRH were mimicked by direct pharmacological activation of protein kinase C (PKC) with beta-phorbol 12-myristate, 13-acetate (PMA).	Tetradecanoylphorbol Acetate	140-143	thyrotropin releasing hormone	Homo sapiens	15-18
7517736-9	1993	The degradation of the fibrin clot involves the tissue-type plasminogen activator tPA, which like the uPA activates plasminogen to plasmin.	Tetradecanoylphorbol Acetate	82-85	plasminogen	Homo sapiens	60-67
7631795-5	1995	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulated both AP-1 binding and transcriptional activity in GH3 cells and the somatostatin analogue octreotide inhibited this response by 40-70%.	Tetradecanoylphorbol Acetate	18-54	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	77-81
7631795-5	1995	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulated both AP-1 binding and transcriptional activity in GH3 cells and the somatostatin analogue octreotide inhibited this response by 40-70%.	Tetradecanoylphorbol Acetate	56-59	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	77-81
9744821-1	1998	Synovial fibroblasts from patients with osteoarthritis in culture produced parathyroid hormone-related peptide (PTHrP) on treatment with phorbol ester (TPA) in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	152-155	parathyroid hormone like hormone	Homo sapiens	75-110
7547506-2	1995	Prolonged treatment of RD cells with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induces growth arrest and myogenic differentiation as shown by the accumulation of alpha-actin and myosin light and heavy chains, without affecting the expression of MyoD and myogenin.	Tetradecanoylphorbol Acetate	112-115	myogenin	Homo sapiens	292-300
7547506-10	1995	We propose that TPA-induced differentiation in RD cells is mediated by the transient activation of PKC alpha, which activates some of the intracellular events that are necessary for MyoD and myogenin transacting activity and for the induction of terminal differentiation of RD cells.	Tetradecanoylphorbol Acetate	16-19	myogenin	Homo sapiens	191-199
8370693-2	1993	Trophoblasts produced hCG in response to rIL-6 as well as to 8-bromo cAMP (8-Br-cAMP), 12-O-tetradecanoyl phorbol-13-acetate (TPA), and calcium ionophore A23187.	Tetradecanoylphorbol Acetate	126-129	glycoprotein hormones, alpha polypeptide	Homo sapiens	22-25
8393875-1	1993	Phosphorylation of threonine 1336 of the human insulin receptor (HIR) is stimulated by insulin or 4 beta-phorbol 12-myristate 13-acetate in Chinese hamster ovary (CHO) transfectant cells expressing the wild type receptor (CHO/HIR).	Tetradecanoylphorbol Acetate	98-136	insulin receptor	Homo sapiens	47-63
9744821-1	1998	Synovial fibroblasts from patients with osteoarthritis in culture produced parathyroid hormone-related peptide (PTHrP) on treatment with phorbol ester (TPA) in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	152-155	parathyroid hormone like hormone	Homo sapiens	112-117
9677316-3	1998	Maximal activation occurred at 15-30 min, but was still detectable after 2 h. Both ERK1 and ERK2 were activated 16-fold by 0.1 mM H2O2 with a similar time course to the SAPKs/JNKs, and this was comparable with their activation by 1 microM PMA, the most powerful activator of ERKs that we have so far identified in these cells.	Tetradecanoylphorbol Acetate	239-242	mitogen activated protein kinase 3	Rattus norvegicus	83-87
8241569-5	1993	EGF in the presence or absence of chronic TPA treatment stimulated marked increases in Cx43 phosphorylation on numerous sites as determined by two-dimensional tryptic phosphopeptide mapping.	Tetradecanoylphorbol Acetate	42-45	gap junction protein alpha 1	Homo sapiens	87-91
8340406-5	1993	When R6-PKC3 cells were treated with the phorbol ester phorbol 12-myristate 13-acetate (PMA) for 30 min, staining with fim-1 or anti-PKC beta 1 revealed a dramatic translocation of PKC to the cell periphery.	Tetradecanoylphorbol Acetate	55-86	FIM1	Homo sapiens	119-124
8340406-5	1993	When R6-PKC3 cells were treated with the phorbol ester phorbol 12-myristate 13-acetate (PMA) for 30 min, staining with fim-1 or anti-PKC beta 1 revealed a dramatic translocation of PKC to the cell periphery.	Tetradecanoylphorbol Acetate	88-91	FIM1	Homo sapiens	119-124
7602115-8	1995	Curcumin markedly inhibited AP-1 binding activity to 12-tetradecanoyl phorbol-13-acetate-responsive element (TRE) in the cytokine-treated cells.	Tetradecanoylphorbol Acetate	53-88	jun proto-oncogene	Mus musculus	28-32
7623773-5	1995	With TPA treatment of the cells for various times (10 min, 90 min, 3 hr, 6 hr, or 24 hr), translocation of PKC-alpha and PKC-delta from the cytosol to the membrane was seen after 10- or 90-min treatment and restoration to basal levels in the membrane fraction was seen after 3-hr treatment.	Tetradecanoylphorbol Acetate	5-8	protein kinase C delta	Homo sapiens	121-130
9677316-3	1998	Maximal activation occurred at 15-30 min, but was still detectable after 2 h. Both ERK1 and ERK2 were activated 16-fold by 0.1 mM H2O2 with a similar time course to the SAPKs/JNKs, and this was comparable with their activation by 1 microM PMA, the most powerful activator of ERKs that we have so far identified in these cells.	Tetradecanoylphorbol Acetate	239-242	mitogen activated protein kinase 1	Rattus norvegicus	92-96
7623773-10	1995	After 10- or 90-min TPA treatment, AIF4(-)--but not Ca2+ ionophore-induced PI hydrolysis was inhibited, whereas [3H]BK binding was unaffected, indicating that the site of action of PKC-alpha and PKC-delta in the BK receptor/G protein/PLC pathway is after the receptor and before PLC, i.e., the G protein.	Tetradecanoylphorbol Acetate	20-23	protein kinase C delta	Homo sapiens	195-204
7686158-6	1993	Insulin, guanosine 5"-O-(3-thiotriphosphate), guanylyl imidodiphosphate, NaF, and phorbol 12-myristate 13-acetate also induced the translocation of GLUT4myc in Chinese hamster ovary cells coexpressing the human insulin receptor.	Tetradecanoylphorbol Acetate	82-113	insulin receptor	Homo sapiens	211-227
7623773-14	1995	The increase in AIF4(-)-induced PI hydrolysis after 24-hr TPA treatment was also inhibited by cycloheximide, indicating that new synthesis of BK receptors and G proteins was required after down-regulation of PKC-alpha and PKC-delta.	Tetradecanoylphorbol Acetate	58-61	protein kinase C delta	Homo sapiens	222-231
9679146-3	1998	This report presents the first evidence that phosphorylation of the MARCKS-related domain modifies in vitro and in vivo activities of adducin involving actin and spectrin, and we demonstrate that adducin is a prominent in vivo substrate for PKC or other phorbol 12-myristate 13-acetate (PMA)-activated kinases in multiple cell types, including neurons.	Tetradecanoylphorbol Acetate	254-285	myristoylated alanine rich protein kinase C substrate	Homo sapiens	68-74
7758124-11	1995	Phytohemagglutinin and phorbol 12-myristate 13-acetate induced a transient increase in the percentage of SUP-T1 cells expressing CR1, compared to cells cultured in media alone.	Tetradecanoylphorbol Acetate	23-54	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	129-132
8352523-3	1993	The results showed that TPA down-modulated the constitutive expression of c-myc, c-myb, and c-fms, mRNA to low but still detectable levels.	Tetradecanoylphorbol Acetate	24-27	colony stimulating factor 1 receptor	Homo sapiens	92-97
9679146-3	1998	This report presents the first evidence that phosphorylation of the MARCKS-related domain modifies in vitro and in vivo activities of adducin involving actin and spectrin, and we demonstrate that adducin is a prominent in vivo substrate for PKC or other phorbol 12-myristate 13-acetate (PMA)-activated kinases in multiple cell types, including neurons.	Tetradecanoylphorbol Acetate	287-290	myristoylated alanine rich protein kinase C substrate	Homo sapiens	68-74
7744871-8	1995	The results indicate that the specific binding of ATF3/Jun and a previously uncharacterized factor account for signal-specific transcription in response to EGF or an activated Ha-ras gene in a cell type in which the cooperative action of an activated Ha-ras gene and 12-O-tetradecanoylphorbol-13-acetate cause tumor growth.	Tetradecanoylphorbol Acetate	267-303	activating transcription factor 3	Mus musculus	50-54
9681997-4	1998	After treatment with phorbol 12-myristate 13-acetate (PMA), hsp70-overexpressing cells (HL-60/hsp70) underwent rapid growth arrest and plastic adherence and expressed more CD14 than parental HL-60 or empty vector-transformed cells (HL-60/puro).	Tetradecanoylphorbol Acetate	21-52	CD14 molecule	Homo sapiens	172-176
8234033-7	1993	Thyrotropin-releasing hormone (1 microM) still increased [3H]DA release even after preincubation with PMA (500 nM) for 24 h, but PMA (100 nM) did not under the same conditions.	Tetradecanoylphorbol Acetate	102-105	thyrotropin releasing hormone	Rattus norvegicus	0-29
9682002-6	1998	Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression.	Tetradecanoylphorbol Acetate	172-175	interleukin 2 receptor subunit alpha	Homo sapiens	232-236
7761103-9	1995	The negative effect on Src kinase activity upon FGFR stimulation was mimicked by activation of PKC in FGFR-1/PAE or CCL 39 cells using phorbol 12-myristate 13-acetate (PMA) and Src was phosphorylated in vitro by purified recombinant PKC alpha.	Tetradecanoylphorbol Acetate	135-166	proto-oncogene tyrosine-protein kinase Src	Cricetulus griseus	23-26
7761103-9	1995	The negative effect on Src kinase activity upon FGFR stimulation was mimicked by activation of PKC in FGFR-1/PAE or CCL 39 cells using phorbol 12-myristate 13-acetate (PMA) and Src was phosphorylated in vitro by purified recombinant PKC alpha.	Tetradecanoylphorbol Acetate	168-171	proto-oncogene tyrosine-protein kinase Src	Cricetulus griseus	23-26
9682002-6	1998	Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression.	Tetradecanoylphorbol Acetate	172-175	CD69 molecule	Homo sapiens	241-245
8505313-3	1993	The immune complex phosphatase assay using the antibody demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) and a vitamin D metabolite increased the PTP activity of immunoprecipitated PTP1C to 230 and 150% of control, respectively.	Tetradecanoylphorbol Acetate	74-110	protein tyrosine phosphatase receptor type U	Homo sapiens	158-161
8505313-3	1993	The immune complex phosphatase assay using the antibody demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) and a vitamin D metabolite increased the PTP activity of immunoprecipitated PTP1C to 230 and 150% of control, respectively.	Tetradecanoylphorbol Acetate	112-115	protein tyrosine phosphatase receptor type U	Homo sapiens	158-161
8505313-9	1993	These results suggest that (i) two subtypes of PTP1C may exist and function in various cell types, and (ii) TPA stimulates the PTP activity of PTP1C by increasing the transcription rate of PTP1C gene expression.	Tetradecanoylphorbol Acetate	108-111	protein tyrosine phosphatase receptor type U	Homo sapiens	47-50
7744791-7	1995	Moreover, although phorbol 12-myristate 13-acetate stimulated both the stable translocation of p47phox and p67phox and sustained NADPH oxidase activity, it did not stimulate p21rac2 translocation.	Tetradecanoylphorbol Acetate	19-50	neutrophil cytosolic factor 2	Homo sapiens	107-114
9662163-8	1998	K- and TNK-tPA, at concentrations as high as 10 microg/ml of blood, caused plasminogen activation that was controlled by the natural plasmin inhibitors, and, thus, no proteolytic degradation of plasma fibrinogen (fibrinogenolysis).	Tetradecanoylphorbol Acetate	11-14	plasminogen	Homo sapiens	75-82
8359866-1	1993	CD8 (Ly-2) expression was suppressed in purified murine CD4-CD8+ thymocytes at the mRNA level upon continuous stimulation with PMA and ionomycin in the presence of rIL-2.	Tetradecanoylphorbol Acetate	127-130	CD8 antigen, alpha chain	Mus musculus	5-9
9720223-0	1998	Stimulation by histamine of TPA-dependent hepatocyte growth factor production in promyelocytic leukemia HL-60 cells.	Tetradecanoylphorbol Acetate	28-31	hepatocyte growth factor	Homo sapiens	42-66
8504805-2	1993	Treatment with okadaic acid caused rapid phosphorylation of five proteins with molecular masses of 65, 55, 50, 28 and 15 kDa (p65, p55, p50, p28, p15, respectively) while TPA caused rapid phosphorylation of five proteins with molecular masses of 80, 70, 40, 34 and 28 kDa (p80, p70, p40, p34, p28, respectively).	Tetradecanoylphorbol Acetate	171-174	interleukin 2 receptor, beta chain	Mus musculus	278-281
8504805-2	1993	Treatment with okadaic acid caused rapid phosphorylation of five proteins with molecular masses of 65, 55, 50, 28 and 15 kDa (p65, p55, p50, p28, p15, respectively) while TPA caused rapid phosphorylation of five proteins with molecular masses of 80, 70, 40, 34 and 28 kDa (p80, p70, p40, p34, p28, respectively).	Tetradecanoylphorbol Acetate	171-174	glutathione S-transferase omega 1	Mus musculus	293-296
8504805-3	1993	In the present study, we examined p28, a common target protein of okadaic acid and TPA.	Tetradecanoylphorbol Acetate	83-86	glutathione S-transferase omega 1	Mus musculus	34-37
7492943-6	1995	Treatment of both cells with TPA for 10 min resulted in the translocation of PKC alpha, PKC delta and PKC epsilon to the membrane fraction.	Tetradecanoylphorbol Acetate	29-32	protein kinase C, epsilon	Mus musculus	102-113
7492943-9	1995	In this condition, the translocation of cPKC alpha, nPKC delta and nPKC epsilon induced by TPA still occurred, however, that of cPKC alpha was reduced more than in the normal condition.	Tetradecanoylphorbol Acetate	91-94	protein kinase C, epsilon	Mus musculus	67-79
7492943-10	1995	After long-term treatment (17 h) with TPA, cPKC alpha, nPKC delta and nPKC epsilon were down-regulated both in the cytosol and membrane.	Tetradecanoylphorbol Acetate	38-41	protein kinase C, epsilon	Mus musculus	70-82
8504805-4	1993	The phosphorylation of p28 increased depending on time of exposure and doses of okadaic acid and TPA.	Tetradecanoylphorbol Acetate	97-100	glutathione S-transferase omega 1	Mus musculus	23-26
9720223-6	1998	12-o-Tetradecanoylphorbol-13-acetate (TPA) markedly stimulated HGF production and release from the cells; the maximal amount of HGF was released at a concentration of 3 ng/ml of TPA.	Tetradecanoylphorbol Acetate	0-36	hepatocyte growth factor	Homo sapiens	63-66
9720223-6	1998	12-o-Tetradecanoylphorbol-13-acetate (TPA) markedly stimulated HGF production and release from the cells; the maximal amount of HGF was released at a concentration of 3 ng/ml of TPA.	Tetradecanoylphorbol Acetate	0-36	hepatocyte growth factor	Homo sapiens	128-131
7766308-1	1995	Tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) induce neoplastic transformation, elevated c-jun protein expression, and activator protein-1 (AP-1)-dependent gene expression in JB6 mouse epidermal cells sensitive to tumor promoters (clone 415a P+ cells).	Tetradecanoylphorbol Acetate	24-60	jun proto-oncogene	Mus musculus	144-149
8320275-3	1993	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a tumour promoter and modulator of PKC activity, decreased PRLR binding activity in all cell lines examined.	Tetradecanoylphorbol Acetate	15-51	prolactin receptor	Homo sapiens	118-122
9720223-6	1998	12-o-Tetradecanoylphorbol-13-acetate (TPA) markedly stimulated HGF production and release from the cells; the maximal amount of HGF was released at a concentration of 3 ng/ml of TPA.	Tetradecanoylphorbol Acetate	38-41	hepatocyte growth factor	Homo sapiens	63-66
8320275-3	1993	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a tumour promoter and modulator of PKC activity, decreased PRLR binding activity in all cell lines examined.	Tetradecanoylphorbol Acetate	53-56	prolactin receptor	Homo sapiens	118-122
7766308-1	1995	Tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) induce neoplastic transformation, elevated c-jun protein expression, and activator protein-1 (AP-1)-dependent gene expression in JB6 mouse epidermal cells sensitive to tumor promoters (clone 415a P+ cells).	Tetradecanoylphorbol Acetate	24-60	jun proto-oncogene	Mus musculus	174-193
7766308-1	1995	Tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) induce neoplastic transformation, elevated c-jun protein expression, and activator protein-1 (AP-1)-dependent gene expression in JB6 mouse epidermal cells sensitive to tumor promoters (clone 415a P+ cells).	Tetradecanoylphorbol Acetate	24-60	jun proto-oncogene	Mus musculus	195-199
8320275-4	1993	In MCF-7 cells, 10 nM TPA caused a 70% loss of PRLR mRNA after 12 h, paralleled 3 h later by a comparable loss of cell surface PRLR.	Tetradecanoylphorbol Acetate	22-25	prolactin receptor	Homo sapiens	47-51
7766308-1	1995	Tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) induce neoplastic transformation, elevated c-jun protein expression, and activator protein-1 (AP-1)-dependent gene expression in JB6 mouse epidermal cells sensitive to tumor promoters (clone 415a P+ cells).	Tetradecanoylphorbol Acetate	62-65	jun proto-oncogene	Mus musculus	144-149
8320275-4	1993	In MCF-7 cells, 10 nM TPA caused a 70% loss of PRLR mRNA after 12 h, paralleled 3 h later by a comparable loss of cell surface PRLR.	Tetradecanoylphorbol Acetate	22-25	prolactin receptor	Homo sapiens	127-131
9720223-6	1998	12-o-Tetradecanoylphorbol-13-acetate (TPA) markedly stimulated HGF production and release from the cells; the maximal amount of HGF was released at a concentration of 3 ng/ml of TPA.	Tetradecanoylphorbol Acetate	38-41	hepatocyte growth factor	Homo sapiens	128-131
8320275-7	1993	No change in the stability of PRLR mRNA was observed during 24 h of TPA treatment and TPA reduced the rate of PRLR gene transcription within 3 h of treatment.	Tetradecanoylphorbol Acetate	86-89	prolactin receptor	Homo sapiens	110-114
7766308-1	1995	Tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) induce neoplastic transformation, elevated c-jun protein expression, and activator protein-1 (AP-1)-dependent gene expression in JB6 mouse epidermal cells sensitive to tumor promoters (clone 415a P+ cells).	Tetradecanoylphorbol Acetate	62-65	jun proto-oncogene	Mus musculus	174-193
7766308-1	1995	Tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) induce neoplastic transformation, elevated c-jun protein expression, and activator protein-1 (AP-1)-dependent gene expression in JB6 mouse epidermal cells sensitive to tumor promoters (clone 415a P+ cells).	Tetradecanoylphorbol Acetate	62-65	jun proto-oncogene	Mus musculus	195-199
8482723-10	1993	Staurosporine inhibited both basal and a TPA-induced phosphorylation of an endogenous 80kDa PKC substrate (p80), and also blocked c-fos proto-oncogene mRNA expression induced by the phorbol ester.	Tetradecanoylphorbol Acetate	41-44	coilin	Homo sapiens	107-110
9720223-6	1998	12-o-Tetradecanoylphorbol-13-acetate (TPA) markedly stimulated HGF production and release from the cells; the maximal amount of HGF was released at a concentration of 3 ng/ml of TPA.	Tetradecanoylphorbol Acetate	178-181	hepatocyte growth factor	Homo sapiens	63-66
9720223-6	1998	12-o-Tetradecanoylphorbol-13-acetate (TPA) markedly stimulated HGF production and release from the cells; the maximal amount of HGF was released at a concentration of 3 ng/ml of TPA.	Tetradecanoylphorbol Acetate	178-181	hepatocyte growth factor	Homo sapiens	128-131
9720223-7	1998	Histamine significantly stimulated the TPA-induced HGF production and release in these cells, depending on incubation time and its dose.	Tetradecanoylphorbol Acetate	39-42	hepatocyte growth factor	Homo sapiens	51-54
7682222-3	1993	At quiescence, the cdc2 gene expression can be reinduced with serum or with other mitogens such as insulin or 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	110-147	cyclin-dependent kinase 1	Mus musculus	19-23
9637721-5	1998	Stimulation of human eosinophils with phorbol myristate acetate in vitro yielded significant release of MIF protein.	Tetradecanoylphorbol Acetate	38-63	macrophage migration inhibitory factor	Homo sapiens	104-107
7682222-3	1993	At quiescence, the cdc2 gene expression can be reinduced with serum or with other mitogens such as insulin or 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	149-152	cyclin-dependent kinase 1	Mus musculus	19-23
8384844-3	1993	Employing Northern blotting, a sandwich enzyme-linked immunosorbent assay and immunocytochemical analysis we determined MRP8/MRP14 mRNA and protein levels, which were found to be elevated after VD3 and reduced after TPA treatment.	Tetradecanoylphorbol Acetate	216-219	S100 calcium binding protein A8	Homo sapiens	120-124
8452879-4	1993	Incubation of splenic T-cells with concanavalin A, phorbol myristate acetate or the ionophore A23187 lead to a similar increase of beta 4 transcript during the S-phase.	Tetradecanoylphorbol Acetate	51-76	tubulin beta 3 class III	Homo sapiens	131-137
8095029-3	1993	Overnight pretreatment of hepatocytes with TPA, which is known to downregulate protein kinase C, abolished the TPA and reduced the EGF-mediated inhibition of PEPCK gene expression.	Tetradecanoylphorbol Acetate	43-46	epidermal growth factor like 1	Rattus norvegicus	131-134
8444879-5	1993	Transient transfection studies demonstrated that stimulation of A20 transcription by TNF, phorbol 12-myristate 13-acetate (PMA), and Tax was mediated by two kappa B elements within the A20 promoter.	Tetradecanoylphorbol Acetate	90-121	TNF alpha induced protein 3	Homo sapiens	64-67
8444879-5	1993	Transient transfection studies demonstrated that stimulation of A20 transcription by TNF, phorbol 12-myristate 13-acetate (PMA), and Tax was mediated by two kappa B elements within the A20 promoter.	Tetradecanoylphorbol Acetate	90-121	TNF alpha induced protein 3	Homo sapiens	185-188
8444879-5	1993	Transient transfection studies demonstrated that stimulation of A20 transcription by TNF, phorbol 12-myristate 13-acetate (PMA), and Tax was mediated by two kappa B elements within the A20 promoter.	Tetradecanoylphorbol Acetate	123-126	TNF alpha induced protein 3	Homo sapiens	64-67
8444879-5	1993	Transient transfection studies demonstrated that stimulation of A20 transcription by TNF, phorbol 12-myristate 13-acetate (PMA), and Tax was mediated by two kappa B elements within the A20 promoter.	Tetradecanoylphorbol Acetate	123-126	TNF alpha induced protein 3	Homo sapiens	185-188
8095460-4	1993	Unlike the anti-TCR antibody, phorbol 12-myristate 13-acetate--a direct activator of PKC--induced the expression of CD 69 on all thymocytes.	Tetradecanoylphorbol Acetate	30-61	CD69 molecule	Homo sapiens	116-121
8436593-3	1993	The NGF-mediated increase in GAP-43 mRNA levels and neurite outgrowth was mimicked by the phorbol ester TPA, but not by dibutyryl cAMP or the calcium ionophore A12783.	Tetradecanoylphorbol Acetate	104-107	nerve growth factor	Rattus norvegicus	4-7
8436593-3	1993	The NGF-mediated increase in GAP-43 mRNA levels and neurite outgrowth was mimicked by the phorbol ester TPA, but not by dibutyryl cAMP or the calcium ionophore A12783.	Tetradecanoylphorbol Acetate	104-107	growth associated protein 43	Rattus norvegicus	29-35
8436593-4	1993	Downregulation of protein kinase C (PKC) by high doses of phorbol esters or selective PKC inhibitors prevented the induction of this mRNA by NGF, suggesting that NGF and TPA act through a common PKC-dependent pathway.	Tetradecanoylphorbol Acetate	170-173	nerve growth factor	Rattus norvegicus	141-144
8483478-0	1993	Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	124-155	nerve growth factor	Rattus norvegicus	0-19
8483478-8	1993	We have also established that the regulatory region of NGFIA that mediates NGF induction also mediates the induction by serum and phorbol 12-myristate 13-acetate, suggesting that multiple signal transduction pathways must converge on these sequences to regulate the expression of this gene.	Tetradecanoylphorbol Acetate	130-161	nerve growth factor	Rattus norvegicus	55-58
8440710-6	1993	Like CRE-BP1, CRE-BPa binds to CRE with higher affinity than to the 12-O-tetradecanoylphorbol-13-acetate response element as a homodimer or a CRE-BPa/c-Jun or CRE-BPa/CRE-BP1 heterodimer.	Tetradecanoylphorbol Acetate	68-104	cAMP responsive element binding protein 5	Homo sapiens	14-21
7678813-11	1993	TPA also increased the expression of GP IIb/IIIa, fibronectin and factor VIII:RAg.	Tetradecanoylphorbol Acetate	0-3	coagulation factor VIII	Mus musculus	66-77
7682535-10	1993	In the presence of a submitogenic dose of the protein kinase C (PKC) activating agent phorbol 12-myristate 13-acetate (PMA), co-stimulation with anti-CD5 or anti-CD28 increased CD69 expression above that induced by PMA alone.	Tetradecanoylphorbol Acetate	86-117	CD28 molecule	Homo sapiens	162-166
7682535-10	1993	In the presence of a submitogenic dose of the protein kinase C (PKC) activating agent phorbol 12-myristate 13-acetate (PMA), co-stimulation with anti-CD5 or anti-CD28 increased CD69 expression above that induced by PMA alone.	Tetradecanoylphorbol Acetate	86-117	CD69 molecule	Homo sapiens	177-181
7682535-10	1993	In the presence of a submitogenic dose of the protein kinase C (PKC) activating agent phorbol 12-myristate 13-acetate (PMA), co-stimulation with anti-CD5 or anti-CD28 increased CD69 expression above that induced by PMA alone.	Tetradecanoylphorbol Acetate	119-122	CD28 molecule	Homo sapiens	162-166
7682535-10	1993	In the presence of a submitogenic dose of the protein kinase C (PKC) activating agent phorbol 12-myristate 13-acetate (PMA), co-stimulation with anti-CD5 or anti-CD28 increased CD69 expression above that induced by PMA alone.	Tetradecanoylphorbol Acetate	119-122	CD69 molecule	Homo sapiens	177-181
8389378-9	1993	Interestingly, cyclin D1 expression is stimulated by the protein kinase C activator TPA, but suppressed by dibutyryl-cAMP and the adenylate cyclase inducer forskolin, pointing to multiple regulatory pathways controlling cyclin D1 expression.	Tetradecanoylphorbol Acetate	84-87	cyclin D1	Homo sapiens	15-24
8425225-4	1993	PKC activators (PMA, diacylglycerol, indolactam) were effective inducers of CD23 gene expression, whereas calcium ionophores were not.	Tetradecanoylphorbol Acetate	16-19	Fc epsilon receptor II	Homo sapiens	76-80
8111971-9	1993	Treatment of oocytes with phorbol 12-myristate 13-acetate, an activator of protein kinase C, for 30 min prior to the addition of 1-MA resulted in the inhibition of 1-MA-induced phosphorylation of eIF-4E, translational activation, and germinal vesicle breakdown.	Tetradecanoylphorbol Acetate	26-57	eukaryotic translation initiation factor 4E	Homo sapiens	196-202
8352882-1	1993	The goal of this study was to compare the response of mouse epidermal keratinocytes (MEKs) and human epidermal keratinocytes (HEKs) to 12-O-tetradecanoylphorbol-13-acetate (TPA) with respect to the activation and downregulation of protein kinase C (PKC), the expression of c-jun and c-fos, and the expression and induction of ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	135-171	ornithine decarboxylase 1	Homo sapiens	326-349
8352882-1	1993	The goal of this study was to compare the response of mouse epidermal keratinocytes (MEKs) and human epidermal keratinocytes (HEKs) to 12-O-tetradecanoylphorbol-13-acetate (TPA) with respect to the activation and downregulation of protein kinase C (PKC), the expression of c-jun and c-fos, and the expression and induction of ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	135-171	ornithine decarboxylase 1	Homo sapiens	351-354
8397795-9	1993	c-fos and c-jun proteins synthesized in vitro could bind to the DNA fragment containing this sequence, but the binding was weaker than to the TPA-responsive element (TGACTCA).	Tetradecanoylphorbol Acetate	142-145	jun proto-oncogene	Mus musculus	10-15
7602783-6	1995	The expression of the second isozyme, Mn-SOD localized at mitochondrial matrix, is regulated in a complex manner by many stimulants such as interleukin-1, -6, tumor necrosis factor, lipopolysaccharide, and tumor promoters phorbol ester (TPA) and okadaic acid.	Tetradecanoylphorbol Acetate	237-240	interleukin 16	Homo sapiens	140-157
7537266-1	1995	The effects of a phorbol ester (TPA) and of members of the Jun and Fos oncoprotein family on the activity of the rat alpha-fetoprotein (AFP) promoter were checked by using transient expression experiments in HepG2 hepatoma cells.	Tetradecanoylphorbol Acetate	32-35	alpha-fetoprotein	Rattus norvegicus	117-134
7537266-1	1995	The effects of a phorbol ester (TPA) and of members of the Jun and Fos oncoprotein family on the activity of the rat alpha-fetoprotein (AFP) promoter were checked by using transient expression experiments in HepG2 hepatoma cells.	Tetradecanoylphorbol Acetate	32-35	alpha-fetoprotein	Rattus norvegicus	136-139
7537266-2	1995	TPA blocked the activity of the rat AFP promoter in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-3	alpha-fetoprotein	Rattus norvegicus	36-39
7794805-7	1995	Expression of gadd45 was induced by TPA in PKC-zeta but not parental cells and occurred as a primary response to TPA and prior to the onset of cell death.	Tetradecanoylphorbol Acetate	36-39	growth arrest and DNA damage inducible alpha	Homo sapiens	14-20
7794805-7	1995	Expression of gadd45 was induced by TPA in PKC-zeta but not parental cells and occurred as a primary response to TPA and prior to the onset of cell death.	Tetradecanoylphorbol Acetate	113-116	growth arrest and DNA damage inducible alpha	Homo sapiens	14-20
7540972-0	1995	Topical application of 12-O-tetradecanoylphorbol-13-acetate induces dyssynchronous expression of keratins K1 and K10 in mouse epidermis.	Tetradecanoylphorbol Acetate	23-59	endothelin receptor type B modifier 1	Mus musculus	113-116
7540972-3	1995	The effect of TPA on the separate expression of the maturation-associated keratins K1 and K10 was studied by immunohistochemistry in an unperturbed replicative keratinocyte population of hairless mice epidermis in relation to changes in the cell cycle time during regeneration.	Tetradecanoylphorbol Acetate	14-17	endothelin receptor type B modifier 1	Mus musculus	90-93
7540972-9	1995	How TPA induces such dyssynchrony in K1 and K10 regulation remains unknown.	Tetradecanoylphorbol Acetate	4-7	endothelin receptor type B modifier 1	Mus musculus	44-47
7536860-7	1995	The response to the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate stimulation of the phosphorylation of CK 8 and CK 18 was also elicited in contrast to control hepatocytes.	Tetradecanoylphorbol Acetate	35-72	keratin 18	Mus musculus	120-125
7534298-3	1995	Raf-BXB is activated by engaging the antigen receptor-CD3 complex, or treating cells with phorbol myristate acetate or okadaic acid.	Tetradecanoylphorbol Acetate	90-115	zinc fingers and homeoboxes 2	Homo sapiens	0-3
7534298-4	1995	Increasing intracellular cAMP inhibits Raf-1 activation stimulated by phorbol myristate acetate, but not the activation of Raf-BXB.	Tetradecanoylphorbol Acetate	70-95	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	39-44
7534298-4	1995	Increasing intracellular cAMP inhibits Raf-1 activation stimulated by phorbol myristate acetate, but not the activation of Raf-BXB.	Tetradecanoylphorbol Acetate	70-95	zinc fingers and homeoboxes 2	Homo sapiens	39-42
7890493-5	1995	Phorbol-12-myristate 13-acetate (PMA) stimulates gelatinase B mRNA and protein synthesis by corneal cells, which is similar to its effect on the other MMPs.	Tetradecanoylphorbol Acetate	0-31	matrix metalloproteinase-9	Oryctolagus cuniculus	49-61
7890493-5	1995	Phorbol-12-myristate 13-acetate (PMA) stimulates gelatinase B mRNA and protein synthesis by corneal cells, which is similar to its effect on the other MMPs.	Tetradecanoylphorbol Acetate	33-36	matrix metalloproteinase-9	Oryctolagus cuniculus	49-61
7785462-6	1995	Both forskolin, a protein kinase A activator, and phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, have previously been shown to induce PGHS-2 mRNA in MC3T3-E1 cells, but in the present study only PMA induced PGHS-2 expression in Py1a cells.	Tetradecanoylphorbol Acetate	50-81	prostaglandin-endoperoxide synthase 2	Mus musculus	162-168
7785462-6	1995	Both forskolin, a protein kinase A activator, and phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, have previously been shown to induce PGHS-2 mRNA in MC3T3-E1 cells, but in the present study only PMA induced PGHS-2 expression in Py1a cells.	Tetradecanoylphorbol Acetate	50-81	prostaglandin-endoperoxide synthase 2	Mus musculus	235-241
7785462-7	1995	The induction of PGHS-2 mRNA in Py1a cells by PGs was inhibited by chelerythrine, a PKC inhibitor, and blocked by 24 h of pretreatment with PMA.	Tetradecanoylphorbol Acetate	140-143	prostaglandin-endoperoxide synthase 2	Mus musculus	17-23
7758843-0	1995	Transcriptional regulation of the lactate dehydrogenase A subunit gene by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	92-128	lactate dehydrogenase A	Rattus norvegicus	34-57
7758843-3	1995	Activators of protein kinase C, such as tetradecanoylphorbol acetate (TPA) and dioctanoylglycerol (DG), caused a 3-4-fold accumulation of LDH A subunit mRNA in rat C6 glioma cells.	Tetradecanoylphorbol Acetate	40-68	lactate dehydrogenase A	Rattus norvegicus	138-143
7758843-3	1995	Activators of protein kinase C, such as tetradecanoylphorbol acetate (TPA) and dioctanoylglycerol (DG), caused a 3-4-fold accumulation of LDH A subunit mRNA in rat C6 glioma cells.	Tetradecanoylphorbol Acetate	70-73	lactate dehydrogenase A	Rattus norvegicus	138-143
7758843-4	1995	The specific protein kinase C inhibitor bisindolylmaleimide GF 109203X prevented the TPA-induced increase of LDH A subunit mRNA.	Tetradecanoylphorbol Acetate	85-88	lactate dehydrogenase A	Rattus norvegicus	109-114
7829270-4	1995	Both DNFB and TPA caused marked induction of ODC, c-fos and c-jun mRNA.	Tetradecanoylphorbol Acetate	14-17	jun proto-oncogene	Mus musculus	60-65
7873388-5	1995	In contrast, phorbol esters (PMA) up-regulate both CD23 isoforms in the malignant B cells and specifically increases type B in normal B cells.	Tetradecanoylphorbol Acetate	29-32	Fc epsilon receptor II	Homo sapiens	51-55
16695971-6	1995	Cells treated with HGF, DMSO, or TPA were also positive for cMET.Conclusions-These data suggest that HGF induced partial monocytic differentiation in HL60 cells.	Tetradecanoylphorbol Acetate	33-36	hepatocyte growth factor	Homo sapiens	101-104
7608139-7	1995	As dibutyryl cyclicAMP (dbcAMP) and tetradecanoylphorbol 13-acetate (TPA), but not Ca(2+)-ionophore A23187 stimulated HGF production in skin fibroblasts, activation of protein kinase-A and protein kinase-C may be coupled to the stimulation of HGF production.	Tetradecanoylphorbol Acetate	69-72	hepatocyte growth factor	Homo sapiens	118-121
7608139-8	1995	Simultaneous addition of PGE1 and TPA or dbcAMP and TPA led to a synergistic enhancement of HGF production, whereas the simultaneous addition of PGE1 and dbcAMP failed to additively enhance HGF production.	Tetradecanoylphorbol Acetate	34-37	hepatocyte growth factor	Homo sapiens	92-95
7608139-8	1995	Simultaneous addition of PGE1 and TPA or dbcAMP and TPA led to a synergistic enhancement of HGF production, whereas the simultaneous addition of PGE1 and dbcAMP failed to additively enhance HGF production.	Tetradecanoylphorbol Acetate	34-37	hepatocyte growth factor	Homo sapiens	190-193
7608139-8	1995	Simultaneous addition of PGE1 and TPA or dbcAMP and TPA led to a synergistic enhancement of HGF production, whereas the simultaneous addition of PGE1 and dbcAMP failed to additively enhance HGF production.	Tetradecanoylphorbol Acetate	52-55	hepatocyte growth factor	Homo sapiens	92-95
7776965-2	1995	Recently, we showed that human CG (hCG)- or phorbol ester- [phorbol 12-myristate-13-acetate (PMA)] stimulation of cells transfected with the LH/CG receptor induced rapid LH/CG receptor phosphorylation and a reduced cAMP response upon reexposure to hCG.	Tetradecanoylphorbol Acetate	93-96	chorionic gonadotropin subunit beta 5	Homo sapiens	31-33
7776965-2	1995	Recently, we showed that human CG (hCG)- or phorbol ester- [phorbol 12-myristate-13-acetate (PMA)] stimulation of cells transfected with the LH/CG receptor induced rapid LH/CG receptor phosphorylation and a reduced cAMP response upon reexposure to hCG.	Tetradecanoylphorbol Acetate	93-96	chorionic gonadotropin subunit beta 5	Homo sapiens	248-251
7870033-5	1995	After translocation, PKC-alpha, -delta, -eta, and -epsilon were down-regulated; the down-regulation of PKC-epsilon contrasts with its retention after phorbol-12-myristate-13-acetate or bryostatin treatment.	Tetradecanoylphorbol Acetate	150-181	protein kinase C, epsilon	Mus musculus	103-114
9637721-6	1998	For example, eosinophils stimulated with phorbol myristate acetate (100 nM, 8 h, 37 degreesC) released 1,539+/-435 pg/10(6) cells of MIF, whereas unstimulated cells released barely detectable levels (&lt; 142 pg/10(6) cells, mean+/-SEM, n = 8).	Tetradecanoylphorbol Acetate	41-66	macrophage migration inhibitory factor	Homo sapiens	133-136
9626657-6	1998	Coexpression of dominant negative and constitutively active forms of CDC42, Rac1, Ras, MEKK1, and MEK1 with JNK indicated that JNK activation by GnRH and TPA is mediated by CDC42 and MEKK1.	Tetradecanoylphorbol Acetate	154-157	cell division cycle 42	Mus musculus	69-74
9626657-6	1998	Coexpression of dominant negative and constitutively active forms of CDC42, Rac1, Ras, MEKK1, and MEK1 with JNK indicated that JNK activation by GnRH and TPA is mediated by CDC42 and MEKK1.	Tetradecanoylphorbol Acetate	154-157	Rac family small GTPase 1	Mus musculus	76-80
9626657-6	1998	Coexpression of dominant negative and constitutively active forms of CDC42, Rac1, Ras, MEKK1, and MEK1 with JNK indicated that JNK activation by GnRH and TPA is mediated by CDC42 and MEKK1.	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase kinase 1	Mus musculus	87-92
9626657-6	1998	Coexpression of dominant negative and constitutively active forms of CDC42, Rac1, Ras, MEKK1, and MEK1 with JNK indicated that JNK activation by GnRH and TPA is mediated by CDC42 and MEKK1.	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase kinase 1	Mus musculus	98-102
9626657-6	1998	Coexpression of dominant negative and constitutively active forms of CDC42, Rac1, Ras, MEKK1, and MEK1 with JNK indicated that JNK activation by GnRH and TPA is mediated by CDC42 and MEKK1.	Tetradecanoylphorbol Acetate	154-157	cell division cycle 42	Mus musculus	173-178
9626657-6	1998	Coexpression of dominant negative and constitutively active forms of CDC42, Rac1, Ras, MEKK1, and MEK1 with JNK indicated that JNK activation by GnRH and TPA is mediated by CDC42 and MEKK1.	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase kinase 1	Mus musculus	183-188
9575800-7	1998	However, protein kinase C (PKC) levels were downregulated in TPA-treated cells but not in alpha qQ209L-expressing cells, suggesting that the regulation of PKC by G alpha q may be different from regulation by TPA.	Tetradecanoylphorbol Acetate	61-64	protein kinase C delta	Homo sapiens	27-30
9575800-7	1998	However, protein kinase C (PKC) levels were downregulated in TPA-treated cells but not in alpha qQ209L-expressing cells, suggesting that the regulation of PKC by G alpha q may be different from regulation by TPA.	Tetradecanoylphorbol Acetate	61-64	protein kinase C delta	Homo sapiens	155-158
9561912-10	1998	More significantly, they express constitutively the c-fms (the receptor of the macrophage growth factor) and, under TPA stimulation, are able to modulate the expression of this receptor and its ligand, as well as TNF-alpha and IL-1.	Tetradecanoylphorbol Acetate	116-119	colony stimulating factor 1 receptor	Homo sapiens	52-57
9525598-8	1998	Moreover, we found that active Raf transactivates the HIV(NL4-3) LTR in A3.01 T lymphocytes and that dominant negative Raf (C4) blocked 12-O-tetradecanoylphorbol-13-acetate induced transactivation.	Tetradecanoylphorbol Acetate	136-172	zinc fingers and homeoboxes 2	Homo sapiens	31-34
7814423-8	1995	Here we investigate possible molecular mechanisms underlying the reciprocal effects of PKC alpha and PKC beta I. Overexpression of both isoforms enhanced 12-O-tetradecanoyl phorbol-13 acetate-induced expression of the growth regulatory genes c-jun, c-myc, and collagenase and enhanced feedback inhibition of epidermal growth factor receptor binding and cellular levels of diacylglycerol.	Tetradecanoylphorbol Acetate	154-191	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	249-254
7818548-2	1995	In contrast to TPA response element (TRE), where overexpression of a variety of PKC isozymes results in enhanced activation by TPA, activation of NF-kappa B by TPA is not enhanced by overexpression of PKC isozymes such as cPKC alpha, nPKC delta, or nPKC theta.	Tetradecanoylphorbol Acetate	127-130	protein kinase C, delta	Rattus norvegicus	80-83
7818548-2	1995	In contrast to TPA response element (TRE), where overexpression of a variety of PKC isozymes results in enhanced activation by TPA, activation of NF-kappa B by TPA is not enhanced by overexpression of PKC isozymes such as cPKC alpha, nPKC delta, or nPKC theta.	Tetradecanoylphorbol Acetate	127-130	protein kinase C, delta	Rattus norvegicus	80-83
8657015-0	1995	Expression of 18.6/CD23 antigen on human lymphoid progenitor cell lines and phorbol 12-myristate 13-acetate (PMA)-induced microglia-shaped cells.	Tetradecanoylphorbol Acetate	76-107	Fc epsilon receptor II	Homo sapiens	19-31
7659180-2	1995	Staurosporine, a protein kinase inhibitor with broad profile of inhibitory activity on diverse protein kinases, but not CGP 41,251 substantially inhibited the TPA-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1, CD54) and to a lesser extent also its ligand CD11a.	Tetradecanoylphorbol Acetate	159-162	integrin subunit alpha L	Homo sapiens	276-281
7796938-3	1995	Using pig granulosa cells cultured in vitro, we studied the effects of protein kinase C activation by tetradecanoylphorbol acetate (TPA) on IGF I mRNA level.	Tetradecanoylphorbol Acetate	102-130	insulin like growth factor 1	Sus scrofa	140-145
7796938-3	1995	Using pig granulosa cells cultured in vitro, we studied the effects of protein kinase C activation by tetradecanoylphorbol acetate (TPA) on IGF I mRNA level.	Tetradecanoylphorbol Acetate	132-135	insulin like growth factor 1	Sus scrofa	140-145
7816604-3	1994	We show that TPA has a direct stimulatory action on the promoter and further that this is mediated by the AP-1 transcription factor.	Tetradecanoylphorbol Acetate	13-16	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-110
7983040-4	1994	Addition of the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted also in a rapid (30 min) and selective increase in PKC beta, but not PKC alpha, mRNA levels.	Tetradecanoylphorbol Acetate	30-66	protein kinase C, beta	Mus musculus	133-141
7983040-4	1994	Addition of the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted also in a rapid (30 min) and selective increase in PKC beta, but not PKC alpha, mRNA levels.	Tetradecanoylphorbol Acetate	68-71	protein kinase C, beta	Mus musculus	133-141
7983040-9	1994	In contrast the effect of TPA on PKC beta mRNA levels was reduced by BAPTA and abolished by removal of Ca2+.	Tetradecanoylphorbol Acetate	26-29	protein kinase C, beta	Mus musculus	33-41
7955154-3	1994	Therefore, we examined whether this recombinant channel was also modulated by protein kinase C activation by investigating the effects of the diacylglycerol analogue phorbol 12-myristate 13-acetate (PMA) on Kv1.4 K+ current expressed in Xenopus oocytes.	Tetradecanoylphorbol Acetate	166-197	potassium voltage-gated channel subfamily A member 4 S homeolog	Xenopus laevis	207-212
7955154-3	1994	Therefore, we examined whether this recombinant channel was also modulated by protein kinase C activation by investigating the effects of the diacylglycerol analogue phorbol 12-myristate 13-acetate (PMA) on Kv1.4 K+ current expressed in Xenopus oocytes.	Tetradecanoylphorbol Acetate	199-202	potassium voltage-gated channel subfamily A member 4 S homeolog	Xenopus laevis	207-212
7982471-0	1994	Molecular cloning of TPAR1, a gene whose expression is repressed by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	87-123	chemokine (C-X-C motif) ligand 12	Mus musculus	21-26
7982471-1	1994	We previously isolated a partial cDNA sequence, termed TPAR1 (TPA repressed gene 1), from a cDNA library constructed from C3H10T1/2 mouse embryo fibroblasts treated with TPA, using a differential screening procedure.	Tetradecanoylphorbol Acetate	55-58	chemokine (C-X-C motif) ligand 12	Mus musculus	62-82
7890813-3	1994	Conversely, when cells were chronically treated with 1 microM TPA at 37 degrees C for 24 h and processed under identical conditions, kinase FA/GSK-3 alpha was found to be rephosphorylated on tyrosine residue and reactivated to approximately 130% of the original control level.	Tetradecanoylphorbol Acetate	62-65	glycogen synthase kinase 3 alpha	Homo sapiens	143-154
7890813-4	1994	Taken together, the results provide initial evidence that the phosphotyrosine content and cellular activity of kinase FA/GSK-3 alpha can be modulated in a reversible manner by short-term and long-term exposure of A431 cells to TPA.	Tetradecanoylphorbol Acetate	227-230	glycogen synthase kinase 3 alpha	Homo sapiens	121-132
7948021-3	1994	The effect of dithiothreitol is opposite to that observed for the Ref-1-mediated binding of Fos/Jun to the ARE or to the related 12-O-tetradecanoyl phorbol-13-acetate responsive element (TRE).	Tetradecanoylphorbol Acetate	129-166	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	66-71
7961875-10	1994	In addition, both HL-60 and HL-60/R-CP cells underwent cell differentiation in response to 12-O-tetradecanoylphorbol-13-acetate, retinoic acid, and dimethyl sulfoxide, resulting in proliferation arrest as well as a remarkable decrease in the c-myc mRNA levels.	Tetradecanoylphorbol Acetate	91-127	opsin 1, long wave sensitive	Homo sapiens	28-38
7954413-6	1994	Fifty-two chemicals were classified as highly positive compounds when examined for their ability to inhibit TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	108-111	ornithine decarboxylase 1	Homo sapiens	120-123
7981246-9	1994	Both activation of glycerophosphate dehydrogenase and stimulation of insulin-dependent 2-deoxyglucose uptake induced by hormones/IBMX were enhanced in protein kinase C-depleted cells exposed to phorbol 12-myristate 13-acetate (PMA), and attenuated in IAP-treated cells.	Tetradecanoylphorbol Acetate	194-225	glycerol-3-phosphate dehydrogenase 1	Homo sapiens	19-49
7981246-9	1994	Both activation of glycerophosphate dehydrogenase and stimulation of insulin-dependent 2-deoxyglucose uptake induced by hormones/IBMX were enhanced in protein kinase C-depleted cells exposed to phorbol 12-myristate 13-acetate (PMA), and attenuated in IAP-treated cells.	Tetradecanoylphorbol Acetate	227-230	glycerol-3-phosphate dehydrogenase 1	Homo sapiens	19-49
7981246-10	1994	The level of a 32P-labeled 52 kDa protein in plasma membrane fractions immunoprecipitated by anti-PI-PLC antiserum was increased by PMA stimulation, abolished in PMA-treated cells, and increased in IAP-treated cells.	Tetradecanoylphorbol Acetate	132-135	phospholipase C beta 1	Homo sapiens	98-104
7981246-10	1994	The level of a 32P-labeled 52 kDa protein in plasma membrane fractions immunoprecipitated by anti-PI-PLC antiserum was increased by PMA stimulation, abolished in PMA-treated cells, and increased in IAP-treated cells.	Tetradecanoylphorbol Acetate	162-165	phospholipase C beta 1	Homo sapiens	98-104
7534491-9	1994	Pretreatment with a high dose of phorbol 12-myristate 13-acetate (PMA), which causes down-regulation in protein kinase C (PKC) activity and PMA-induced HGF secretion, did not reduce the effects of the growth factors on HGF mRNA expression and HGF secretion, but rather enhanced them.	Tetradecanoylphorbol Acetate	33-64	hepatocyte growth factor	Homo sapiens	152-155
7534491-9	1994	Pretreatment with a high dose of phorbol 12-myristate 13-acetate (PMA), which causes down-regulation in protein kinase C (PKC) activity and PMA-induced HGF secretion, did not reduce the effects of the growth factors on HGF mRNA expression and HGF secretion, but rather enhanced them.	Tetradecanoylphorbol Acetate	66-69	hepatocyte growth factor	Homo sapiens	152-155
7931322-6	1994	The reduction in MARCKS protein levels was maximal following 24 h of PMA exposure.	Tetradecanoylphorbol Acetate	69-72	myristoylated alanine rich protein kinase C substrate	Homo sapiens	17-23
7931322-10	1994	Addition of the PKC inhibitor GF109203X blocked the down-regulation of MARCKS protein in PMA-treated cultures but not in retinoic acid-treated cells.	Tetradecanoylphorbol Acetate	89-92	myristoylated alanine rich protein kinase C substrate	Homo sapiens	71-77
7963658-4	1994	We have found that in cultured human keratinocytes, TPA cases a marked decrease in ornithine decarboxylase enzyme activity (50-90%), with no detectable effect on ornithine decarboxylase mRNA levels.	Tetradecanoylphorbol Acetate	52-55	ornithine decarboxylase 1	Homo sapiens	83-106
7963658-5	1994	TPA decreased steady-state levels of ornithine decarboxylase immunoreactive protein (approximately 50-67%), accounting for the 50-90% suppression of ornithine decarboxylase activity levels, as well as decreasing new synthesis of ornithine decarboxylase protein (48-50%).	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase 1	Homo sapiens	37-60
7963658-5	1994	TPA decreased steady-state levels of ornithine decarboxylase immunoreactive protein (approximately 50-67%), accounting for the 50-90% suppression of ornithine decarboxylase activity levels, as well as decreasing new synthesis of ornithine decarboxylase protein (48-50%).	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase 1	Homo sapiens	149-172
7963658-5	1994	TPA decreased steady-state levels of ornithine decarboxylase immunoreactive protein (approximately 50-67%), accounting for the 50-90% suppression of ornithine decarboxylase activity levels, as well as decreasing new synthesis of ornithine decarboxylase protein (48-50%).	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase 1	Homo sapiens	149-172
7963658-7	1994	Also, prolonged treatment of keratinocytes with phorbol esters abolished the suppression of ornithine decarboxylase activity by TPA.	Tetradecanoylphorbol Acetate	128-131	ornithine decarboxylase 1	Homo sapiens	92-115
7929360-5	1994	On the other hand, epidermal growth factor causes a prolonged activation of Raf-1 kinase and ERK activity and a smaller, more transient activation of JNK, whereas the phorbol ester phorbol 12-myristate 13-acetate causes a small stimulation of Raf-1 kinase and a pronounced stimulation of ERK activity.	Tetradecanoylphorbol Acetate	181-212	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	243-248
7929360-7	1994	The kinetics of Raf-1, ERK, and JNK induction by epidermal growth factor, phorbol 12-myristate 13-acetate, or TNF alpha indicate distinct mechanisms of activation in human fibroblasts.	Tetradecanoylphorbol Acetate	74-105	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	16-21
7869421-3	1994	The exposure to MC and/or PMA caused a rapid increase in c-fos mRNA content, which was immediately followed by an increase in c-jun mRNA, prior to NGF mRNA elevation.	Tetradecanoylphorbol Acetate	26-29	jun proto-oncogene	Mus musculus	126-131
7919377-0	1994	Regulation of intercellular adhesion molecule-1 gene expression involves multiple mRNA stabilization mechanisms: effects of interferon-gamma and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	145-170	intercellular adhesion molecule 1	Mus musculus	14-47
7919377-2	1994	Interferon-gamma (IFN-gamma) and phorbol myristate acetate (PMA) are known to increase the expression of ICAM-1 on many cell types.	Tetradecanoylphorbol Acetate	33-58	intercellular adhesion molecule 1	Mus musculus	105-111
7919377-2	1994	Interferon-gamma (IFN-gamma) and phorbol myristate acetate (PMA) are known to increase the expression of ICAM-1 on many cell types.	Tetradecanoylphorbol Acetate	60-63	intercellular adhesion molecule 1	Mus musculus	105-111
7919377-10	1994	However, unlike IFN-gamma, PMA treatment only increased the level of the full-length, but not of the truncated, ICAM-1 mRNA.	Tetradecanoylphorbol Acetate	27-30	intercellular adhesion molecule 1	Mus musculus	112-118
7815740-2	1994	When growth-arrested MC were stimulated with 100 nM phorbol myristate acetate (PMA) for 24 hours, an increased expression of smooth muscle alpha-actin and vimentin was detected by immunocytochemistry.	Tetradecanoylphorbol Acetate	52-77	vimentin	Rattus norvegicus	155-163
7815740-2	1994	When growth-arrested MC were stimulated with 100 nM phorbol myristate acetate (PMA) for 24 hours, an increased expression of smooth muscle alpha-actin and vimentin was detected by immunocytochemistry.	Tetradecanoylphorbol Acetate	79-82	vimentin	Rattus norvegicus	155-163
8089151-2	1994	Treatment of A7r5 cells with vasopressin, phorbol ester (PMA), or serum resulted in activation of two MAPKs, Erk-1 and Erk-2.	Tetradecanoylphorbol Acetate	57-60	mitogen activated protein kinase 3	Rattus norvegicus	109-114
8089151-2	1994	Treatment of A7r5 cells with vasopressin, phorbol ester (PMA), or serum resulted in activation of two MAPKs, Erk-1 and Erk-2.	Tetradecanoylphorbol Acetate	57-60	mitogen activated protein kinase 1	Rattus norvegicus	119-124
8083228-1	1994	The requirement for protein kinase C (PKC)-beta in phorbol 12-myristate 13-acetate (PMA)-induced macrophage differentiation of human HL-60 promyelocytic leukemia cells was studied by using the variant HL-525, which is deficient in PKC-beta and is resistant to PMA-induced differentiation.	Tetradecanoylphorbol Acetate	51-82	protein kinase C beta	Homo sapiens	20-47
8083228-1	1994	The requirement for protein kinase C (PKC)-beta in phorbol 12-myristate 13-acetate (PMA)-induced macrophage differentiation of human HL-60 promyelocytic leukemia cells was studied by using the variant HL-525, which is deficient in PKC-beta and is resistant to PMA-induced differentiation.	Tetradecanoylphorbol Acetate	84-87	protein kinase C beta	Homo sapiens	20-47
8083228-6	1994	Therefore, we can conclude that PKC-beta is one of the essential elements in the PMA-induced signal transduction pathway which leads to macrophage differentiation in HL-60 cells and perhaps in other related cell types.	Tetradecanoylphorbol Acetate	81-84	protein kinase C beta	Homo sapiens	32-40
9525598-8	1998	Moreover, we found that active Raf transactivates the HIV(NL4-3) LTR in A3.01 T lymphocytes and that dominant negative Raf (C4) blocked 12-O-tetradecanoylphorbol-13-acetate induced transactivation.	Tetradecanoylphorbol Acetate	136-172	zinc fingers and homeoboxes 2	Homo sapiens	119-122
9495248-0	1998	PMA-induced reduction in invasiveness is associated with hyperphosphorylation of MARCKS and talin in invasive bladder cancer cells.	Tetradecanoylphorbol Acetate	0-3	myristoylated alanine rich protein kinase C substrate	Homo sapiens	81-87
9555062-3	1998	Both AP-1 and ENKCRE-2 DNA binding activities were markedly increased at 1-4 h by PMA treatment and these PMA-induced responses were inhibited by pre-treatment with CHX, showing that the increase of proENK mRNA level was well correlated with the AP-1 and ENKCRE-2 DNA binding activities.	Tetradecanoylphorbol Acetate	82-85	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	5-9
7888303-5	1994	PKC activation by phorbol ester TPA increased the effect of EGF alone as well as the oxysterol potentiating effect, whereas PKC down-regulation strongly decreased both of these effects, showing that both are dependent on PKC activity.	Tetradecanoylphorbol Acetate	32-35	epidermal growth factor like 1	Rattus norvegicus	60-63
8093097-1	1994	We found that CsA inhibited O2- formation in HL-60 cells induced by PMA (30 nM) and phorbol dibutyrate (200 nM) with a half-maximal effect at 1 and 0.75 microM, respectively.	Tetradecanoylphorbol Acetate	68-71	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	14-17
9555062-3	1998	Both AP-1 and ENKCRE-2 DNA binding activities were markedly increased at 1-4 h by PMA treatment and these PMA-induced responses were inhibited by pre-treatment with CHX, showing that the increase of proENK mRNA level was well correlated with the AP-1 and ENKCRE-2 DNA binding activities.	Tetradecanoylphorbol Acetate	82-85	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	246-250
8068015-0	1994	Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells.	Tetradecanoylphorbol Acetate	23-54	solute carrier family 2 member 1	Rattus norvegicus	96-101
9555062-3	1998	Both AP-1 and ENKCRE-2 DNA binding activities were markedly increased at 1-4 h by PMA treatment and these PMA-induced responses were inhibited by pre-treatment with CHX, showing that the increase of proENK mRNA level was well correlated with the AP-1 and ENKCRE-2 DNA binding activities.	Tetradecanoylphorbol Acetate	106-109	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	5-9
8067455-4	1994	However, stimulation of protein kinase C with phorbol 12-myristate 13-acetate (PMA) resulted in greater ACTH release and greater inhibition by DEX in sheep AP cells.	Tetradecanoylphorbol Acetate	46-77	pro-opiomelanocortin-alpha	Mus musculus	104-108
9555062-3	1998	Both AP-1 and ENKCRE-2 DNA binding activities were markedly increased at 1-4 h by PMA treatment and these PMA-induced responses were inhibited by pre-treatment with CHX, showing that the increase of proENK mRNA level was well correlated with the AP-1 and ENKCRE-2 DNA binding activities.	Tetradecanoylphorbol Acetate	106-109	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	246-250
8067455-4	1994	However, stimulation of protein kinase C with phorbol 12-myristate 13-acetate (PMA) resulted in greater ACTH release and greater inhibition by DEX in sheep AP cells.	Tetradecanoylphorbol Acetate	79-82	pro-opiomelanocortin-alpha	Mus musculus	104-108
8067455-7	1994	Whereas NIF also inhibited PMA-induced ACTH secretion in AtT-20 cells, it did not in sheep AP cells.	Tetradecanoylphorbol Acetate	27-30	pro-opiomelanocortin-alpha	Mus musculus	39-43
9506439-3	1998	We previously demonstrated that involucrin promoter activity is stimulated by TPA in cultured fetal rat skin keratinocytes.	Tetradecanoylphorbol Acetate	78-81	involucrin	Rattus norvegicus	32-42
9506439-7	1998	Transfection of the CAT-involucrin promoter expression vector with PKC-alpha or PKC-eta expression vectors resulted in a significant increase in the TPA-dependent involucrin promoter activity.	Tetradecanoylphorbol Acetate	149-152	involucrin	Rattus norvegicus	24-34
9506439-7	1998	Transfection of the CAT-involucrin promoter expression vector with PKC-alpha or PKC-eta expression vectors resulted in a significant increase in the TPA-dependent involucrin promoter activity.	Tetradecanoylphorbol Acetate	149-152	endothelin receptor type A	Homo sapiens	84-87
7519126-5	1994	Expression of the introduced ICAM-1 and/or LFA-3 by transfected cells enhanced their ability to bind LAK-T cells; the LFA-1/ICAM-1-mediated binding was not further enhanced by activation with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	192-223	intercellular adhesion molecule 1	Mus musculus	29-35
9506439-7	1998	Transfection of the CAT-involucrin promoter expression vector with PKC-alpha or PKC-eta expression vectors resulted in a significant increase in the TPA-dependent involucrin promoter activity.	Tetradecanoylphorbol Acetate	149-152	involucrin	Rattus norvegicus	163-173
9506439-12	1998	Both the basal and the TPA-stimulated involucrin promoter activities were suppressed by deleting the AP1-1 site (-119 to -113) that is the most proximal to the transcription start site.	Tetradecanoylphorbol Acetate	23-26	involucrin	Rattus norvegicus	38-48
9506439-14	1998	Gel retardation analyses disclosed that TPA stimulated the specific DNA binding of the nuclear protein(s) of control, PKC-alpha, or PKC-eta-transfected SVHK cells, but not of PKC-gamma-transfected cells.	Tetradecanoylphorbol Acetate	40-43	endothelin receptor type A	Homo sapiens	5-8
7530592-6	1994	The potentiation by insulin of NE-induced tone was not altered by endothelium removal and could be mimicked by phorbol-12-myristate-13-acetate (PMA, 0.1 microM).	Tetradecanoylphorbol Acetate	111-142	insulin	Oryctolagus cuniculus	20-27
9506439-16	1998	These results indicate that PKC, specifically PKC-alpha and PKC-eta, mediates the TPA-dependent activation of involucrin gene expression of SVHK cells.	Tetradecanoylphorbol Acetate	82-85	endothelin receptor type A	Homo sapiens	64-67
7518388-3	1994	The agonist-induced expression of PRGs was mimicked by activation of protein kinase-C with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which acted additively with GnRH at low concentrations of both stimuli.	Tetradecanoylphorbol Acetate	109-140	gonadotropin releasing hormone 1	Homo sapiens	176-180
9506439-16	1998	These results indicate that PKC, specifically PKC-alpha and PKC-eta, mediates the TPA-dependent activation of involucrin gene expression of SVHK cells.	Tetradecanoylphorbol Acetate	82-85	involucrin	Rattus norvegicus	110-120
9506439-17	1998	PKC-gamma, which is not present in keratinocytes, also induces involucrin gene expression in a TPA-independent manner, when introduced into SVHK cells.	Tetradecanoylphorbol Acetate	95-98	involucrin	Rattus norvegicus	63-73
9548589-9	1998	The cPLA2 was activated by TPA, and appeared to be responsible for the majority of the specific release of AA observed in mouse keratinocytes treated with TPA.	Tetradecanoylphorbol Acetate	27-30	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	4-9
7518388-3	1994	The agonist-induced expression of PRGs was mimicked by activation of protein kinase-C with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which acted additively with GnRH at low concentrations of both stimuli.	Tetradecanoylphorbol Acetate	142-145	gonadotropin releasing hormone 1	Homo sapiens	176-180
9486128-5	1998	In contrast, prior activation of PKC with TPA produced desensitization to thrombin and histamine, indicating heterologous PAR-1 desensitization.	Tetradecanoylphorbol Acetate	42-45	protein kinase C beta	Homo sapiens	33-36
7518388-4	1994	Depletion of cellular protein kinase-C by prior treatment with PMA reduced GnRH- and PMA-induced expression of PRGs.	Tetradecanoylphorbol Acetate	63-66	gonadotropin releasing hormone 1	Homo sapiens	75-79
9486128-7	1998	Depletion of PKC beta isozymes (PKC beta I and PKC beta II) by transducing cells with antisense cDNA of PKC beta I prevented the TPA-induced decrease in cell surface PAR-1 expression and restored approximately 60% of the cytosolic Ca2+ signal in response to thrombin.	Tetradecanoylphorbol Acetate	129-132	protein kinase C beta	Homo sapiens	13-21
9486128-7	1998	Depletion of PKC beta isozymes (PKC beta I and PKC beta II) by transducing cells with antisense cDNA of PKC beta I prevented the TPA-induced decrease in cell surface PAR-1 expression and restored approximately 60% of the cytosolic Ca2+ signal in response to thrombin.	Tetradecanoylphorbol Acetate	129-132	protein kinase C beta	Homo sapiens	32-40
9486128-7	1998	Depletion of PKC beta isozymes (PKC beta I and PKC beta II) by transducing cells with antisense cDNA of PKC beta I prevented the TPA-induced decrease in cell surface PAR-1 expression and restored approximately 60% of the cytosolic Ca2+ signal in response to thrombin.	Tetradecanoylphorbol Acetate	129-132	protein kinase C beta	Homo sapiens	32-40
9437048-0	1998	Phorbol myristate acetate downregulates the binding sites for colony-stimulating factor-1 on osteoclasts isolated from rats.	Tetradecanoylphorbol Acetate	0-25	colony stimulating factor 1	Rattus norvegicus	62-89
8056031-4	1994	Stimulation of IL-2R alpha+ and IL-2R alpha- immature thymocytes with phorbol 12-myristate 13-acetate and calcium ionophore induces synthesis of IL-2R alpha and IL-2R beta mRNA.	Tetradecanoylphorbol Acetate	70-101	interleukin 2 receptor, beta chain	Mus musculus	161-171
8035171-4	1994	The action of IL-1 was not mediated by PKC because treatment of cells with maximal concentrations of both IL-1 and TPA gave an additive increase in NGF mRNA content and NGF secretion, and because down-regulating PKC activity failed to inhibit the stimulatory effects of IL-1.	Tetradecanoylphorbol Acetate	115-118	nerve growth factor	Rattus norvegicus	148-151
8035171-4	1994	The action of IL-1 was not mediated by PKC because treatment of cells with maximal concentrations of both IL-1 and TPA gave an additive increase in NGF mRNA content and NGF secretion, and because down-regulating PKC activity failed to inhibit the stimulatory effects of IL-1.	Tetradecanoylphorbol Acetate	115-118	nerve growth factor	Rattus norvegicus	169-172
9437048-2	1998	We tested whether phorbol myristate acetate (PMA), a phorbol ester activating protein kinase C, modulates the number of binding sites for CSF-1 on isolated rat osteoclasts.	Tetradecanoylphorbol Acetate	18-43	colony stimulating factor 1	Rattus norvegicus	138-143
9437048-2	1998	We tested whether phorbol myristate acetate (PMA), a phorbol ester activating protein kinase C, modulates the number of binding sites for CSF-1 on isolated rat osteoclasts.	Tetradecanoylphorbol Acetate	45-48	colony stimulating factor 1	Rattus norvegicus	138-143
8048538-0	1994	3"-untranslated region of SP-B mRNA mediates inhibitory effects of TPA and TNF-alpha on SP-B expression.	Tetradecanoylphorbol Acetate	67-70	surfactant protein B	Homo sapiens	26-30
9437048-3	1998	PMA decreased binding of CSF-1 to osteoclasts within 60 minutes.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 1	Rattus norvegicus	25-30
8048538-0	1994	3"-untranslated region of SP-B mRNA mediates inhibitory effects of TPA and TNF-alpha on SP-B expression.	Tetradecanoylphorbol Acetate	67-70	surfactant protein B	Homo sapiens	88-92
8048538-4	1994	Inhibitory effects of TPA and TNF-alpha on SP-B mRNA expression in vitro were mediated by decreased SP-B mRNA stability rather than by decreased rate of SP-B gene transcription.	Tetradecanoylphorbol Acetate	22-25	surfactant protein B	Homo sapiens	43-47
9437048-8	1998	Antiserum against CSF-1, which was added to osteoclasts contaminated with other cells, mainly osteoblasts, partially inhibited the effect of PMA, but the antiserum had no effect in pure osteoclasts.	Tetradecanoylphorbol Acetate	141-144	colony stimulating factor 1	Rattus norvegicus	18-23
8048538-4	1994	Inhibitory effects of TPA and TNF-alpha on SP-B mRNA expression in vitro were mediated by decreased SP-B mRNA stability rather than by decreased rate of SP-B gene transcription.	Tetradecanoylphorbol Acetate	22-25	surfactant protein B	Homo sapiens	100-104
9437048-13	1998	The CSF-1 binding sites on osteoclasts recovered within 4 hours after removal of PMA, and cycloheximide, an inhibitor of protein synthesis, inhibited the recovery.	Tetradecanoylphorbol Acetate	81-84	colony stimulating factor 1	Rattus norvegicus	4-9
8048538-4	1994	Inhibitory effects of TPA and TNF-alpha on SP-B mRNA expression in vitro were mediated by decreased SP-B mRNA stability rather than by decreased rate of SP-B gene transcription.	Tetradecanoylphorbol Acetate	22-25	surfactant protein B	Homo sapiens	100-104
8048538-6	1994	The mRNAs and cellular growth hormone protein generated from the chimeric TKGH(SP-B2.0) and TKGH(SP-B.837) genes were each inhibited by approximately 50% by TPA and TNF-alpha.	Tetradecanoylphorbol Acetate	157-160	surfactant protein B	Homo sapiens	79-83
9435274-11	1998	In contrast to the native (Jurkat) lymphocyte Kv1.3 channel that is fully inhibited by PKA and PKC, the addition of TPA resulted in 34.6 +/- 7.3% and 38.7 +/- 9.4% inhibition of the full-length and the truncated channels, respectively, 8-BrcAMP induced a 39.4 +/- 5.4% inhibition of the full-length channel but had no effect (8.6 +/- 8.3%) on the truncated channel.	Tetradecanoylphorbol Acetate	116-119	potassium voltage-gated channel subfamily A member 3	Homo sapiens	46-51
8048538-8	1994	The inhibition of steady-state hGH-SP-B mRNA by TPA and TNF-alpha was mediated by a cis-active element located in the 3-UTR region of SP-B mRNA.	Tetradecanoylphorbol Acetate	48-51	surfactant protein B	Homo sapiens	35-39
8048538-8	1994	The inhibition of steady-state hGH-SP-B mRNA by TPA and TNF-alpha was mediated by a cis-active element located in the 3-UTR region of SP-B mRNA.	Tetradecanoylphorbol Acetate	48-51	surfactant protein B	Homo sapiens	134-138
9467942-4	1998	Moreover, all lines that expressed chimeras were capable of anchorage-independent growth in the presence of TPA, which indicated that both the regulatory and catalytic domains of PKC-epsilon could independently induce NIH3T3 transformation, although the combination of both domains, as found in PKC-epsilon, was the most active form.	Tetradecanoylphorbol Acetate	108-111	protein kinase C, epsilon	Mus musculus	179-190
8014008-7	1994	Treatment of HCT 116 and GEO cells with a phorbol ester (TPA) resulted in a 4-fold increase in TGF-alpha in the conditioned media of both cell types.	Tetradecanoylphorbol Acetate	57-60	transforming growth factor alpha	Homo sapiens	95-104
8014008-8	1994	The TPA-induced release of TGF-alpha was blocked by an inhibitor of elastase-like enzymes.	Tetradecanoylphorbol Acetate	4-7	transforming growth factor alpha	Homo sapiens	27-36
8014008-11	1994	The presence of an elastase-like activity in detergent extracts and the ability of an elastase inhibitor to block the TPA-induced secretion of TGF-alpha suggests that PKC and an elastase-like enzyme are involved in the processing and secretion of TGF-alpha by human colon carcinoma cell lines.	Tetradecanoylphorbol Acetate	118-121	transforming growth factor alpha	Homo sapiens	143-152
8014008-11	1994	The presence of an elastase-like activity in detergent extracts and the ability of an elastase inhibitor to block the TPA-induced secretion of TGF-alpha suggests that PKC and an elastase-like enzyme are involved in the processing and secretion of TGF-alpha by human colon carcinoma cell lines.	Tetradecanoylphorbol Acetate	118-121	transforming growth factor alpha	Homo sapiens	247-256
10452822-4	1998	GnT-V and alpha1,6 Fuc T declined, while GnT-III was elevated after induction by 0.1 micromol/l PMA for 3 days.	Tetradecanoylphorbol Acetate	96-99	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	41-48
9455888-3	1998	The highest EA-D levels in viable cells occurred in Raji cells treated with both TPA and n-butyrate and untreated X50-7 cells.	Tetradecanoylphorbol Acetate	81-84	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	12-16
7516337-5	1994	It was possible, however, to activate Raf-1, MEK-1, and p42MAPK in J.CaM1 cells during treatment with the phorbol ester phorbol 12-myristate 13-acetate, which activates protein kinase C (PKC).	Tetradecanoylphorbol Acetate	120-151	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	38-43
9455888-4	1998	TPA and n-butyrate acted synergistically to induce latent EBV, resulting in increased levels of EA-D production in Raji cells and cell death in X50-7 cells.	Tetradecanoylphorbol Acetate	0-3	collagen like tail subunit of asymmetric acetylcholinesterase	Homo sapiens	96-100
7516899-3	1994	The tyrosine phosphorylation of PKC delta is restricted to the activated state of the enzyme, i.e. it occurs only in the presence of an activator, such as TPA or bryostatin.	Tetradecanoylphorbol Acetate	155-158	protein kinase C delta	Homo sapiens	32-41
9704334-10	1998	Phorbol 12-myristate 13-acetate (PMA, 2 or 5 nM) protected CCE cells against apoptosis induced by the introduction of TGF-beta 1 and withdrawal of aFGF, bFGF or VEGF, while H7 (50 microM), but not HA1004 (50 microM), abrogated the protective effect of PMA on CCE apoptosis.	Tetradecanoylphorbol Acetate	33-36	fibroblast growth factor 2	Mus musculus	153-157
9778689-4	1998	Transient (up to 24 h) treatment of HL-60 or K562 leukemia cells with phorbol 12-myristate 13-acetate (TPA) resulted in increased steady-state level of LRP (lung resistance-related protein) mRNA and protein.	Tetradecanoylphorbol Acetate	70-101	major vault protein	Homo sapiens	152-155
7522299-7	1994	NGF also increased PKC activity in cell extracts in a similar way to phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	69-94	nerve growth factor	Rattus norvegicus	0-3
9778689-4	1998	Transient (up to 24 h) treatment of HL-60 or K562 leukemia cells with phorbol 12-myristate 13-acetate (TPA) resulted in increased steady-state level of LRP (lung resistance-related protein) mRNA and protein.	Tetradecanoylphorbol Acetate	70-101	major vault protein	Homo sapiens	157-188
9778689-4	1998	Transient (up to 24 h) treatment of HL-60 or K562 leukemia cells with phorbol 12-myristate 13-acetate (TPA) resulted in increased steady-state level of LRP (lung resistance-related protein) mRNA and protein.	Tetradecanoylphorbol Acetate	103-106	major vault protein	Homo sapiens	152-155
8194480-8	1994	Phorbol 12-myristate 13-acetate at 1 microM increased PDGF-A mRNA after 2-6 h and PDGF-AA polypeptide levels after 24 h by 2-fold.	Tetradecanoylphorbol Acetate	0-31	platelet derived growth factor subunit A	Rattus norvegicus	54-60
9778689-4	1998	Transient (up to 24 h) treatment of HL-60 or K562 leukemia cells with phorbol 12-myristate 13-acetate (TPA) resulted in increased steady-state level of LRP (lung resistance-related protein) mRNA and protein.	Tetradecanoylphorbol Acetate	103-106	major vault protein	Homo sapiens	157-188
9778689-8	1998	In HL-60 cells, the LRP activation by TPA or Ara C was sustained for at least 23 days after withdrawal of inducing agents.	Tetradecanoylphorbol Acetate	38-41	major vault protein	Homo sapiens	20-23
9778689-9	1998	bis-Indolylmaleimide I, a potent PKC inhibitor, attenuated TPA-induced LRP activation.	Tetradecanoylphorbol Acetate	59-62	major vault protein	Homo sapiens	71-74
8189216-5	1994	In addition, nuclear run-on assay indicated an increase in the transcription of AT1 receptor mRNA in WKY rat brain neurons treated with either PMA or forskolin.	Tetradecanoylphorbol Acetate	143-146	angiotensin II receptor, type 1a	Rattus norvegicus	80-83
10063971-7	1998	We also explored the PKC mechanism(s) responsible for the synergism of TPA and gemcitabine, and determined that treatment with 10 nM TPA for 24 h in BG-1 cells: 1) downregulated PKCdelta and PKCalpha, without affecting PKCepsilon, 2) did not affect cell cycle distribution into S phase.	Tetradecanoylphorbol Acetate	133-136	protein kinase C delta	Homo sapiens	178-186
8189216-6	1994	Both PMA and forskolin also stimulate levels of AT1 receptor mRNA in neuronal cultures from brain of the SH rat.	Tetradecanoylphorbol Acetate	5-8	angiotensin II receptor, type 1a	Rattus norvegicus	48-51
10223619-6	1998	TPA-treated PC Cl 3 cells are unable to trap iodide and the expression levels of thyroglobulin, TSH receptor, and TPO genes are drastically reduced by TPA treatment.	Tetradecanoylphorbol Acetate	0-3	thyroid peroxidase	Rattus norvegicus	114-117
10223619-6	1998	TPA-treated PC Cl 3 cells are unable to trap iodide and the expression levels of thyroglobulin, TSH receptor, and TPO genes are drastically reduced by TPA treatment.	Tetradecanoylphorbol Acetate	151-154	thyroid peroxidase	Rattus norvegicus	114-117
7948425-6	1994	In the IL-1-responsive cell line OA strongly synergized with phorbol myristate acetate (PMA) and IL-1.	Tetradecanoylphorbol Acetate	61-86	interleukin 1 complex	Mus musculus	7-11
7948425-6	1994	In the IL-1-responsive cell line OA strongly synergized with phorbol myristate acetate (PMA) and IL-1.	Tetradecanoylphorbol Acetate	88-91	interleukin 1 complex	Mus musculus	7-11
12168042-1	1998	hIL-5 cDNA was amplified through reverse transcription-polymerase chain reaction from peripheral blood lymphocytes induced with PMA and calcium ionophore A23187.	Tetradecanoylphorbol Acetate	128-131	interleukin 5	Homo sapiens	0-5
7948425-7	1994	In the IL-1-nonresponsive cell line OA synergized with PMA but not with IL-1.	Tetradecanoylphorbol Acetate	55-58	interleukin 1 complex	Mus musculus	7-11
8197564-8	1994	Incubation experiments revealed a simultaneous in vitro release of VIP and PP with a significant increase by either carbachol or phorbol myristate acetate but not by theophylline or caerulein.	Tetradecanoylphorbol Acetate	129-154	pancreatic polypeptide	Homo sapiens	75-77
9388190-3	1997	Further analysis revealed that TPA treatment induced, dependently on protein kinase C, the mobility shift of p66(shc) in SDS-polyacrylamide gel electrophoresis, which could be prevented by treatment of the Shc immunoprecipitate with serine/threonine-specific protein phosphatase 1 (PP1) or 2A (PP2A).	Tetradecanoylphorbol Acetate	31-34	protein phosphatase 1 catalytic subunit gamma	Mus musculus	282-285
8203529-8	1994	The tumor promotor phorbol 12-myristate 13-acetate (PMA) stimulated recovery rate from acid load and also increased resting pHi.	Tetradecanoylphorbol Acetate	19-50	glucose-6-phosphate isomerase	Homo sapiens	124-127
8203529-8	1994	The tumor promotor phorbol 12-myristate 13-acetate (PMA) stimulated recovery rate from acid load and also increased resting pHi.	Tetradecanoylphorbol Acetate	52-55	glucose-6-phosphate isomerase	Homo sapiens	124-127
9388190-3	1997	Further analysis revealed that TPA treatment induced, dependently on protein kinase C, the mobility shift of p66(shc) in SDS-polyacrylamide gel electrophoresis, which could be prevented by treatment of the Shc immunoprecipitate with serine/threonine-specific protein phosphatase 1 (PP1) or 2A (PP2A).	Tetradecanoylphorbol Acetate	31-34	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	294-298
9388190-5	1997	Like growth factor-induced Shc phosphorylation, which leads to the association of Shc with Grb2, TPA also induced this association, but, correspondingly to the above results, the TPA-induced association was disrupted by in vitro treatment of the Shc immunoprecipitate with PP1.	Tetradecanoylphorbol Acetate	97-100	protein phosphatase 1 catalytic subunit gamma	Mus musculus	273-276
9388190-5	1997	Like growth factor-induced Shc phosphorylation, which leads to the association of Shc with Grb2, TPA also induced this association, but, correspondingly to the above results, the TPA-induced association was disrupted by in vitro treatment of the Shc immunoprecipitate with PP1.	Tetradecanoylphorbol Acetate	179-182	protein phosphatase 1 catalytic subunit gamma	Mus musculus	273-276
9419420-7	1997	Treatment with Epo or 12-O-tetradecanoyl-phorbol-13-acetate (TPA) up-regulated expression of GATA-2 and Bcl-xL, and these elevations were inhibited by inhibitors of protein kinase C (PKC), H7 and H8.	Tetradecanoylphorbol Acetate	22-59	GATA binding protein 2	Homo sapiens	93-99
8156901-5	1994	The secretion of GLP-1 over a 2-h incubation period amounted to 1.4 +/- 0.3% of the total GLP-1 cell content and was significantly increased by 10 microM forskolin and 100 nM 12-O-tetradecanoylphorbol 13-acetate to 206% and 574% of control values, respectively.	Tetradecanoylphorbol Acetate	175-211	glucagon	Mus musculus	17-22
9419420-7	1997	Treatment with Epo or 12-O-tetradecanoyl-phorbol-13-acetate (TPA) up-regulated expression of GATA-2 and Bcl-xL, and these elevations were inhibited by inhibitors of protein kinase C (PKC), H7 and H8.	Tetradecanoylphorbol Acetate	61-64	GATA binding protein 2	Homo sapiens	93-99
8175715-5	1994	The sequence at position -52 to -40 (mLF-CRE) of the gene conferred transcriptional activation in the presence of forskolin, cyclic AMP, and 12-O-tetradecanoylphorbol-13-acetate in transiently transfected human endometrium carcinoma RL95-2 cells, whereas the region at -80 to -60 responded to EGF/TGF-alpha stimulation.	Tetradecanoylphorbol Acetate	141-177	transforming growth factor alpha	Homo sapiens	297-306
9419424-7	1997	We also found that DNA polymerase delta, replication factor C, and proliferating cell nuclear antigen are absent in cells that are induced to differentiate in response to 12-O-tetradecanoyl phorbol-13-acetate treatment but are present in actively cycling cells.	Tetradecanoylphorbol Acetate	171-208	DNA polymerase delta 1, catalytic subunit	Homo sapiens	19-39
7908894-5	1994	The relative levels of MRP in K562/TPA were the same as in K562.	Tetradecanoylphorbol Acetate	35-38	ATP binding cassette subfamily C member 3	Homo sapiens	23-26
9369943-5	1997	Under certain conditions, PD 098059 can completely block the PMA-induced activation of the p42ERK as monitored by immunoprecipitation kinase assay by using the substrate myelin basic protein.	Tetradecanoylphorbol Acetate	61-64	myelin basic protein	Homo sapiens	170-190
9452362-1	1997	Activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) increased steady-state levels of mRNA encoding the major histocompatibility complex (MHC) class II antigen I-A beta and the class II antigen-associated invariant chain (Ii, CD74) in A20 B lymphoma cells and in normal mouse B cells.	Tetradecanoylphorbol Acetate	40-76	CD74 molecule	Homo sapiens	256-260
8150544-2	1994	The response of c-jun was elicited by the protein kinase-C activators TPA and A23187 in ESb but not in Eb cells.	Tetradecanoylphorbol Acetate	70-73	jun proto-oncogene	Mus musculus	16-21
9452362-1	1997	Activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) increased steady-state levels of mRNA encoding the major histocompatibility complex (MHC) class II antigen I-A beta and the class II antigen-associated invariant chain (Ii, CD74) in A20 B lymphoma cells and in normal mouse B cells.	Tetradecanoylphorbol Acetate	78-81	CD74 molecule	Homo sapiens	256-260
8014197-7	1994	Contrary to 3T3 fibroblasts, where ras-p21 is functionally dependent for its mitogenic activity on TPA- and staurosporine-sensitive PKC isoforms, in Xenopus oocytes, induction of GVBD by ras-p21 was independent of PKC, while PLC-induced GVBD was sensitive to PKC inhibition.	Tetradecanoylphorbol Acetate	99-102	cyclin-dependent kinase inhibitor 1A L homeolog	Xenopus laevis	39-42
9863191-8	1997	However, the TFPI activities in the PMA group and the A23187 + PMA group were markedly higher than those in the control group and the A23187 group (P &lt; 0.01).	Tetradecanoylphorbol Acetate	36-39	tissue factor pathway inhibitor	Homo sapiens	13-17
7518008-4	1994	The effects on MBP gene expression modulated by TPA and cAMP involve altered DNA-protein interactions in the 5" end of the MBP promoter.	Tetradecanoylphorbol Acetate	48-51	myelin basic protein	Homo sapiens	15-18
7518008-4	1994	The effects on MBP gene expression modulated by TPA and cAMP involve altered DNA-protein interactions in the 5" end of the MBP promoter.	Tetradecanoylphorbol Acetate	48-51	myelin basic protein	Homo sapiens	123-126
9863191-8	1997	However, the TFPI activities in the PMA group and the A23187 + PMA group were markedly higher than those in the control group and the A23187 group (P &lt; 0.01).	Tetradecanoylphorbol Acetate	63-66	tissue factor pathway inhibitor	Homo sapiens	13-17
8139561-10	1994	Stimulation with tetradecanoyl phorbol acetate (TPA) resulted in the nuclear translocation of both NF-kappa B and c-Rel-p65 (RelA) in HeLa cells and of NF-kappa B in HepG2 cells but had no effect on either complex in K562 cells.	Tetradecanoylphorbol Acetate	17-46	RELA proto-oncogene, NF-kB subunit	Homo sapiens	120-123
9368070-1	1997	Phosphorylation of alphaB-crystallin, a member of the hsp27 family, in human glioma (U373 MG) cells was stimulated by exposure of the cells to various stimuli, which included heat, arsenite, phorbol 12-myristate 13-acetate (PMA), okadaic acid, H2O2, anisomycin, and high concentrations of NaCl or sorbitol, but not in response to agents that elevated intracellular levels of cyclic AMP.	Tetradecanoylphorbol Acetate	191-222	crystallin, alpha B	Rattus norvegicus	19-36
8139561-10	1994	Stimulation with tetradecanoyl phorbol acetate (TPA) resulted in the nuclear translocation of both NF-kappa B and c-Rel-p65 (RelA) in HeLa cells and of NF-kappa B in HepG2 cells but had no effect on either complex in K562 cells.	Tetradecanoylphorbol Acetate	17-46	RELA proto-oncogene, NF-kB subunit	Homo sapiens	125-129
8139561-10	1994	Stimulation with tetradecanoyl phorbol acetate (TPA) resulted in the nuclear translocation of both NF-kappa B and c-Rel-p65 (RelA) in HeLa cells and of NF-kappa B in HepG2 cells but had no effect on either complex in K562 cells.	Tetradecanoylphorbol Acetate	48-51	RELA proto-oncogene, NF-kB subunit	Homo sapiens	120-123
8139561-10	1994	Stimulation with tetradecanoyl phorbol acetate (TPA) resulted in the nuclear translocation of both NF-kappa B and c-Rel-p65 (RelA) in HeLa cells and of NF-kappa B in HepG2 cells but had no effect on either complex in K562 cells.	Tetradecanoylphorbol Acetate	48-51	RELA proto-oncogene, NF-kB subunit	Homo sapiens	125-129
8139561-11	1994	In addition, TPA stimulation of HepG2 cells induced the expression of a cytosolic latent c-Rel-p65 (RelA) complex which, however, was not translocated to the nucleus.	Tetradecanoylphorbol Acetate	13-16	RELA proto-oncogene, NF-kB subunit	Homo sapiens	95-98
9368070-1	1997	Phosphorylation of alphaB-crystallin, a member of the hsp27 family, in human glioma (U373 MG) cells was stimulated by exposure of the cells to various stimuli, which included heat, arsenite, phorbol 12-myristate 13-acetate (PMA), okadaic acid, H2O2, anisomycin, and high concentrations of NaCl or sorbitol, but not in response to agents that elevated intracellular levels of cyclic AMP.	Tetradecanoylphorbol Acetate	224-227	crystallin, alpha B	Rattus norvegicus	19-36
8139561-11	1994	In addition, TPA stimulation of HepG2 cells induced the expression of a cytosolic latent c-Rel-p65 (RelA) complex which, however, was not translocated to the nucleus.	Tetradecanoylphorbol Acetate	13-16	RELA proto-oncogene, NF-kB subunit	Homo sapiens	100-104
9368070-7	1997	The PMA-induced phosphorylation was selectively suppressed by an inhibitor of p44 MAP kinase kinase, PD98059.	Tetradecanoylphorbol Acetate	4-7	interferon induced protein 44	Homo sapiens	78-81
8148055-8	1994	Immunohistochemical staining of tissue sections of normal and TPA-treated skin revealed the presence of extracellular TGF-beta 1 protein in the dermis and intracellular TGF-beta 1 protein in the epidermis, especially in the suprabasal layers.	Tetradecanoylphorbol Acetate	62-65	transforming growth factor, beta 1	Mus musculus	118-128
8148055-8	1994	Immunohistochemical staining of tissue sections of normal and TPA-treated skin revealed the presence of extracellular TGF-beta 1 protein in the dermis and intracellular TGF-beta 1 protein in the epidermis, especially in the suprabasal layers.	Tetradecanoylphorbol Acetate	62-65	transforming growth factor, beta 1	Mus musculus	169-179
9388466-3	1997	Either the depletion of PKC by prolonged treatment of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) or the inhibition of PKC by a selective PKC inhibitor, UCN-01-ME, attenuated UVC-activation of ERK1/2, keeping the activation of JNK1/2 intact.	Tetradecanoylphorbol Acetate	65-101	mitogen-activated protein kinase 3	Mus musculus	203-209
9360988-4	1997	A C/EBP-binding site within the CD11c promoter (CEBP-80) is bound by CEBPalpha in undifferentiated U937 cells and by C/EBPalpha- and C/EBPbeta-containing dimers in phorbol 12-myristate 13-acetate-differentiating cells, and its disruption decreased the CD11c promoter activity in a cell type-dependent manner.	Tetradecanoylphorbol Acetate	164-195	integrin subunit alpha X	Homo sapiens	32-37
9360988-4	1997	A C/EBP-binding site within the CD11c promoter (CEBP-80) is bound by CEBPalpha in undifferentiated U937 cells and by C/EBPalpha- and C/EBPbeta-containing dimers in phorbol 12-myristate 13-acetate-differentiating cells, and its disruption decreased the CD11c promoter activity in a cell type-dependent manner.	Tetradecanoylphorbol Acetate	164-195	integrin subunit alpha X	Homo sapiens	252-257
9348306-5	1997	In contrast, PMA-induced ruffling was not inhibited by expression of Rac1 N17, but was blocked by expression of Cdc42 N17, indicating that cytoskeletal inhibition by these constructs was nonoverlapping.	Tetradecanoylphorbol Acetate	13-16	cell division cycle 42	Homo sapiens	112-117
8144881-0	1994	Identification of a 52-kDa molecule (p52) coprecipitated with the Ig receptor-related MB-1 protein that is inducibly phosphorylated by the stimulation with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	156-181	similar to Mitochondrial processing peptidase beta subunit, mitochondrial precursor (Beta-MPP; P-52)	Rattus norvegicus	37-40
7510523-5	1994	However, 8-Br-cAMP and TPA acted synergistically to induce PGE2 production equal to that of IL-1.	Tetradecanoylphorbol Acetate	23-26	interleukin 1 complex	Mus musculus	92-96
9374733-5	1997	Phorbol 12-myristate 13-acetate (PMA)-stimulated p47phox phosphorylation was negligibly affected by 25 or 100 microM t-BOOH.	Tetradecanoylphorbol Acetate	0-31	neutrophil cytosolic factor 1	Rattus norvegicus	49-56
8125975-2	1994	Following anti-IgM antibody and phorbol 12-myristate 13-acetate (PMA) stimulation, we demonstrate the activation of Ras, Raf-1, and MAPK/ERK kinase (MEK), all of which are thought to participate in an important signaling cascade that leads to MAPK activation.	Tetradecanoylphorbol Acetate	32-63	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	121-126
8125975-2	1994	Following anti-IgM antibody and phorbol 12-myristate 13-acetate (PMA) stimulation, we demonstrate the activation of Ras, Raf-1, and MAPK/ERK kinase (MEK), all of which are thought to participate in an important signaling cascade that leads to MAPK activation.	Tetradecanoylphorbol Acetate	65-68	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	121-126
9374733-5	1997	Phorbol 12-myristate 13-acetate (PMA)-stimulated p47phox phosphorylation was negligibly affected by 25 or 100 microM t-BOOH.	Tetradecanoylphorbol Acetate	33-36	neutrophil cytosolic factor 1	Rattus norvegicus	49-56
9409458-10	1997	In vitro stimulation by IL-1 beta, TNF alpha or phorbol 12-myristate 13-acetate induced an increase in total CD44 messenger RNA in HGF but not change in overall patterns of CD44 isoform expression.	Tetradecanoylphorbol Acetate	48-79	hepatocyte growth factor	Homo sapiens	131-134
7912405-12	1994	Similarly sphingosine treatment or preincubation with PMA, which reduce protein kinase C (PKC) activity and attenuate the induction of TH mRNA by PMA or the hormone, angiotensin II, did not affect the induction by veratridine.	Tetradecanoylphorbol Acetate	54-57	tyrosine hydroxylase	Bos taurus	135-137
8018556-7	1994	(a) Only PKC-alpha and PKC-epsilon are down-regulated by 12-O-tetradecanoylphorbol-13-acetate whereas PKC-delta and PKC-zeta are not.	Tetradecanoylphorbol Acetate	57-93	protein kinase C, epsilon	Mus musculus	23-34
7517692-5	1994	After stimulation by TPA for 3 days, only the appearance of CD25 (Tac antigen) was detected by immunofluorescence and flow cytometry.	Tetradecanoylphorbol Acetate	21-24	interleukin 2 receptor subunit alpha	Homo sapiens	60-64
7517692-5	1994	After stimulation by TPA for 3 days, only the appearance of CD25 (Tac antigen) was detected by immunofluorescence and flow cytometry.	Tetradecanoylphorbol Acetate	21-24	interleukin 2 receptor subunit alpha	Homo sapiens	66-77
7510294-2	1994	12-O-Tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C, decreased the secretion of immunoreactive IGF-I into the medium, whereas dibutyryl cAMP (Bt2cAMP) augmented the secretion.	Tetradecanoylphorbol Acetate	0-36	insulin-like growth factor 1	Mus musculus	120-125
7510294-2	1994	12-O-Tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C, decreased the secretion of immunoreactive IGF-I into the medium, whereas dibutyryl cAMP (Bt2cAMP) augmented the secretion.	Tetradecanoylphorbol Acetate	38-41	insulin-like growth factor 1	Mus musculus	120-125
8120094-1	1994	We observed that phorbol myristate acetate (PMA) stimulates transcytosis of the polymeric immunoglobulin receptor (pIgR) in MDCK cells.	Tetradecanoylphorbol Acetate	17-42	polymeric immunoglobulin receptor	Canis lupus familiaris	80-113
8120094-1	1994	We observed that phorbol myristate acetate (PMA) stimulates transcytosis of the polymeric immunoglobulin receptor (pIgR) in MDCK cells.	Tetradecanoylphorbol Acetate	17-42	polymeric immunoglobulin receptor	Canis lupus familiaris	115-119
8120094-1	1994	We observed that phorbol myristate acetate (PMA) stimulates transcytosis of the polymeric immunoglobulin receptor (pIgR) in MDCK cells.	Tetradecanoylphorbol Acetate	44-47	polymeric immunoglobulin receptor	Canis lupus familiaris	80-113
8120094-1	1994	We observed that phorbol myristate acetate (PMA) stimulates transcytosis of the polymeric immunoglobulin receptor (pIgR) in MDCK cells.	Tetradecanoylphorbol Acetate	44-47	polymeric immunoglobulin receptor	Canis lupus familiaris	115-119
7906937-6	1994	The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 showed almost complete inhibition of the increase in intracellular peroxide levels of the endothelial cells exposed to PMA-stimulated leukocytes.	Tetradecanoylphorbol Acetate	184-187	integrin subunit alpha L	Homo sapiens	34-39
8308000-8	1994	Expression of PKC beta in PET cells can be restored by exposing them to dihydroxyvitamin D3, and this treatment restores the ability of subsequently added 12-deoxyphorbol 13-phenylacetate 20-acetate or TPA to induce immediate cell adherence and growth arrest of PET cells.	Tetradecanoylphorbol Acetate	202-205	protein kinase C beta	Homo sapiens	14-22
8206872-5	1994	Phorbol myristate acetate (PMA) and 1-oleoyl-2-acetyl-sn-glycerol induced the release of lactoferrin alone at concentrations of Ca2+ below 0.5 microM while they induced the release of both beta-glucuronidase and lactoferrin at higher Ca2+ concentrations, indicating that the degranulation induced by PA10 is not mediated by diacylglycerol which might be formed from PA.	Tetradecanoylphorbol Acetate	0-25	glucuronidase beta	Homo sapiens	189-207
8206872-5	1994	Phorbol myristate acetate (PMA) and 1-oleoyl-2-acetyl-sn-glycerol induced the release of lactoferrin alone at concentrations of Ca2+ below 0.5 microM while they induced the release of both beta-glucuronidase and lactoferrin at higher Ca2+ concentrations, indicating that the degranulation induced by PA10 is not mediated by diacylglycerol which might be formed from PA.	Tetradecanoylphorbol Acetate	27-30	glucuronidase beta	Homo sapiens	189-207
8294465-4	1994	Bryostatin 1 was markedly more potent than PMA for translocating PKC delta but showed a biphasic dose-response curve for down-regulating this isozyme.	Tetradecanoylphorbol Acetate	43-46	protein kinase C delta	Homo sapiens	65-74
8206753-4	1994	In T cells stimulated with purified phytohemagglutinin (PHA-p) and 4 beta-phorbol 12-myristate 13-acetate (PMA) addition of DM to the cultures resulted in a 60% reduction in IL-2R alpha and a 30% reduction in IL-2R beta membrane expression compared to T cells cultured in the absence of DM (p &lt; 0.01).	Tetradecanoylphorbol Acetate	67-105	interleukin 2 receptor subunit alpha	Homo sapiens	174-185
8206753-4	1994	In T cells stimulated with purified phytohemagglutinin (PHA-p) and 4 beta-phorbol 12-myristate 13-acetate (PMA) addition of DM to the cultures resulted in a 60% reduction in IL-2R alpha and a 30% reduction in IL-2R beta membrane expression compared to T cells cultured in the absence of DM (p &lt; 0.01).	Tetradecanoylphorbol Acetate	107-110	interleukin 2 receptor subunit alpha	Homo sapiens	174-185
8206753-4	1994	In T cells stimulated with purified phytohemagglutinin (PHA-p) and 4 beta-phorbol 12-myristate 13-acetate (PMA) addition of DM to the cultures resulted in a 60% reduction in IL-2R alpha and a 30% reduction in IL-2R beta membrane expression compared to T cells cultured in the absence of DM (p &lt; 0.01).	Tetradecanoylphorbol Acetate	107-110	interleukin 2 receptor subunit beta	Homo sapiens	209-219
8270871-3	1994	Stimulation of human neutrophils with PMA greatly increased O2(-)-generating activity and caused considerable translocation of the cytosolic components p47phox and p67phox.	Tetradecanoylphorbol Acetate	38-41	neutrophil cytosolic factor 2	Homo sapiens	164-171
7512195-2	1994	Activation of PKC by 12-O-tetradecanoylphorbol-13-acetate in the CHO-PKC alpha cells inhibited by approximately 75% the: 1) insulin-stimulated increase in antiphosphotyrosine precipitable phosphatidylinositol 3-kinase activity in these cells; 2) insulin-stimulated increase in PI 3-kinase activity associated with insulin receptor substrate-1; and 3) tyrosine phosphorylation of the endogenous substrate, insulin receptor substrate-1.	Tetradecanoylphorbol Acetate	21-57	insulin receptor substrate 1	Cricetulus griseus	314-342
8264601-0	1994	Induction of Drosophila RNA polymerase III gene expression by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is mediated by transcription factor IIIB.	Tetradecanoylphorbol Acetate	118-121	RNA polymerase III 128kD subunit	Drosophila melanogaster	24-42
7841543-5	1994	Northern blot analysis demonstrated that androgen induction of human glandular kallikrein-1 (hKLK2) mRNA was repressed by TPA in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	122-125	kallikrein 1	Homo sapiens	69-91
7743322-4	1994	PMA (10 ng/ml) increased CD32w expression while protein kinase C inhibitors H-7 and staurosporine but not the protein kinase A inhibitor H-9 reversed the effect of hypoxemia on phagocytosis and receptor expression.	Tetradecanoylphorbol Acetate	0-3	Fc gamma receptor IIa	Homo sapiens	25-29
8253775-7	1993	The rapidity and the protein synthesis-independent nature of TPA-induced T-AP1 activation suggests that this complex is involved in the earliest stages of T-cell activation.	Tetradecanoylphorbol Acetate	61-64	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-78
8253535-1	1993	We previously found that the enhanced activity to invade Matrigel upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) was one of the major properties of a highly metastatic variant (L-10) of a human rectal adenocarcinoma cell line RCM-1.	Tetradecanoylphorbol Acetate	88-124	ribosomal protein L10	Homo sapiens	195-199
8253535-1	1993	We previously found that the enhanced activity to invade Matrigel upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) was one of the major properties of a highly metastatic variant (L-10) of a human rectal adenocarcinoma cell line RCM-1.	Tetradecanoylphorbol Acetate	126-129	ribosomal protein L10	Homo sapiens	195-199
8253535-4	1993	TPA markedly enhanced both haptotactic response to type-IV collagen and motility on tissue-culture glass substrate of L-10 cells in a dose-response manner quite similar to that of TPA-enhanced invasion of Matrigel.	Tetradecanoylphorbol Acetate	0-3	ribosomal protein L10	Homo sapiens	118-122
8253535-7	1993	Thus, TPA treatment of L-10 cells enhanced invasion of Matrigel in association with augmentation of cell motility but did not enhance metalloproteinase activity.	Tetradecanoylphorbol Acetate	6-9	ribosomal protein L10	Homo sapiens	23-27
8306878-1	1993	Protease Nexin-1 (PN-1) also known as Glia-Derived Nexin (GDN) inhibits the activity of several serine proteases including thrombin, tissue (tPA)- and urokinase (uPA)-type plasminogen activators.	Tetradecanoylphorbol Acetate	141-144	serine (or cysteine) peptidase inhibitor, clade E, member 2	Mus musculus	0-16
8306878-1	1993	Protease Nexin-1 (PN-1) also known as Glia-Derived Nexin (GDN) inhibits the activity of several serine proteases including thrombin, tissue (tPA)- and urokinase (uPA)-type plasminogen activators.	Tetradecanoylphorbol Acetate	141-144	serine (or cysteine) peptidase inhibitor, clade E, member 2	Mus musculus	18-22
8306878-1	1993	Protease Nexin-1 (PN-1) also known as Glia-Derived Nexin (GDN) inhibits the activity of several serine proteases including thrombin, tissue (tPA)- and urokinase (uPA)-type plasminogen activators.	Tetradecanoylphorbol Acetate	141-144	serine (or cysteine) peptidase inhibitor, clade E, member 2	Mus musculus	38-56
8306878-1	1993	Protease Nexin-1 (PN-1) also known as Glia-Derived Nexin (GDN) inhibits the activity of several serine proteases including thrombin, tissue (tPA)- and urokinase (uPA)-type plasminogen activators.	Tetradecanoylphorbol Acetate	141-144	serine (or cysteine) peptidase inhibitor, clade E, member 2	Mus musculus	58-61
8306878-5	1993	In the embryonic spinal cord, PN-1 expression occurs in cells lining the neural canal that are different from the cells previously shown to express tPA.	Tetradecanoylphorbol Acetate	148-151	serine (or cysteine) peptidase inhibitor, clade E, member 2	Mus musculus	30-34
7504676-6	1993	Priming neutrophils with 1 nM PMA, a low concentration that did not influence the F-actin content per se, increased the magnitude of the beta 2 integrin-induced response but had no effect on the kinetics (199% after 30 s and 169% after 300 s).	Tetradecanoylphorbol Acetate	30-33	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	137-143
7504676-7	1993	Removal of extracellular Ca2+ only marginally affected the beta 2 integrin-induced F-actin response for cells that were pretreated with PMA whereas the response for nonprimed cells was reduced by half.	Tetradecanoylphorbol Acetate	136-139	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	59-65
8250869-0	1993	Enhanced expression of the mouse L-histidine decarboxylase gene with a combination of dexamethasone and 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	104-140	histidine decarboxylase	Mus musculus	33-58
8250869-1	1993	We previously reported that the induction of L-histidine decarboxylase (HDC) in mouse mastocytoma cells was synergistically potentiated with a combination of dexamethasone and 12-O-tetradecanoylphorbol-13-acetate (TPA) [Biochim.	Tetradecanoylphorbol Acetate	176-212	histidine decarboxylase	Mus musculus	45-70
8250869-1	1993	We previously reported that the induction of L-histidine decarboxylase (HDC) in mouse mastocytoma cells was synergistically potentiated with a combination of dexamethasone and 12-O-tetradecanoylphorbol-13-acetate (TPA) [Biochim.	Tetradecanoylphorbol Acetate	176-212	histidine decarboxylase	Mus musculus	72-75
8250869-1	1993	We previously reported that the induction of L-histidine decarboxylase (HDC) in mouse mastocytoma cells was synergistically potentiated with a combination of dexamethasone and 12-O-tetradecanoylphorbol-13-acetate (TPA) [Biochim.	Tetradecanoylphorbol Acetate	214-217	histidine decarboxylase	Mus musculus	45-70
8250869-1	1993	We previously reported that the induction of L-histidine decarboxylase (HDC) in mouse mastocytoma cells was synergistically potentiated with a combination of dexamethasone and 12-O-tetradecanoylphorbol-13-acetate (TPA) [Biochim.	Tetradecanoylphorbol Acetate	214-217	histidine decarboxylase	Mus musculus	72-75
8250869-7	1993	With mastocytoma cells transiently transfected with 5" deletion constructs of HDC-CAT fusion gene, it was found that the sequence from -267 to -43 is essential for the regulatory elements(s) involved in the increased transcription of the HDC gene with dexamethasone and TPA.	Tetradecanoylphorbol Acetate	270-273	histidine decarboxylase	Mus musculus	78-81
8250869-7	1993	With mastocytoma cells transiently transfected with 5" deletion constructs of HDC-CAT fusion gene, it was found that the sequence from -267 to -43 is essential for the regulatory elements(s) involved in the increased transcription of the HDC gene with dexamethasone and TPA.	Tetradecanoylphorbol Acetate	270-273	histidine decarboxylase	Mus musculus	238-241
8238525-6	1993	Stimulation of Caco-2 cell monolayers with phorbol myristate acetate or with the combination of carbachol and monolein was also associated with phosphorylation of the MARCKS protein, an endogenous substrate of PKC.	Tetradecanoylphorbol Acetate	43-68	myristoylated alanine rich protein kinase C substrate	Homo sapiens	167-173
8242759-1	1993	The expression of CD23 on human tonsillar B cells is increased following treatment with interleukin 4 (IL-4) or 12-O-tetradecanoylphorbol 13-acetate (TPA), while that of surface immunoglobulins (sIgs) is increased by IL-4 but decreased by TPA.	Tetradecanoylphorbol Acetate	112-148	Fc epsilon receptor II	Homo sapiens	18-22
8242759-1	1993	The expression of CD23 on human tonsillar B cells is increased following treatment with interleukin 4 (IL-4) or 12-O-tetradecanoylphorbol 13-acetate (TPA), while that of surface immunoglobulins (sIgs) is increased by IL-4 but decreased by TPA.	Tetradecanoylphorbol Acetate	150-153	Fc epsilon receptor II	Homo sapiens	18-22
8242759-1	1993	The expression of CD23 on human tonsillar B cells is increased following treatment with interleukin 4 (IL-4) or 12-O-tetradecanoylphorbol 13-acetate (TPA), while that of surface immunoglobulins (sIgs) is increased by IL-4 but decreased by TPA.	Tetradecanoylphorbol Acetate	239-242	Fc epsilon receptor II	Homo sapiens	18-22
8242759-7	1993	In comparison, the up-regulation of CD23 by IL-4 and TPA was only partially blocked by these PKC inhibitors.	Tetradecanoylphorbol Acetate	53-56	Fc epsilon receptor II	Homo sapiens	36-40
8242759-8	1993	TK inhibitors, such as herbimycin A and genistein, decreased both the IL-4- and TPA-induced CD23 expression by 50-80%, but had modest effects on sIgs expression.	Tetradecanoylphorbol Acetate	80-83	Fc epsilon receptor II	Homo sapiens	92-96
8223435-6	1993	Also TPA-induced, p21ras-independent, activation of raf-1 kinase and ERK2 is inhibited by cAMP.	Tetradecanoylphorbol Acetate	5-8	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	52-57
8223435-6	1993	Also TPA-induced, p21ras-independent, activation of raf-1 kinase and ERK2 is inhibited by cAMP.	Tetradecanoylphorbol Acetate	5-8	mitogen activated protein kinase 1	Rattus norvegicus	69-73
8223446-5	1993	This increase in Raf-1 expression allowed antibodies to CD3 and to CD28 to stimulate IL2 production in the absence of phorbol myristate acetate (PMA) and enhanced IL2 production stimulated by these antibodies in the presence of PMA.	Tetradecanoylphorbol Acetate	118-143	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	17-22
8223446-5	1993	This increase in Raf-1 expression allowed antibodies to CD3 and to CD28 to stimulate IL2 production in the absence of phorbol myristate acetate (PMA) and enhanced IL2 production stimulated by these antibodies in the presence of PMA.	Tetradecanoylphorbol Acetate	118-143	CD28 molecule	Homo sapiens	67-71
8223446-5	1993	This increase in Raf-1 expression allowed antibodies to CD3 and to CD28 to stimulate IL2 production in the absence of phorbol myristate acetate (PMA) and enhanced IL2 production stimulated by these antibodies in the presence of PMA.	Tetradecanoylphorbol Acetate	145-148	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	17-22
8223876-2	1993	The region extending from -317 to +47 relative to the initiation site of IL-2 gene transcription was shown to contain sequences able to respond to CD69 cross-linking, by enhancing by about 100% a phorbol 12-myristate 13-acetate (PMA)-plus-ionomycin stimulation of CAT activity.	Tetradecanoylphorbol Acetate	196-227	CD69 molecule	Homo sapiens	147-151
8223876-2	1993	The region extending from -317 to +47 relative to the initiation site of IL-2 gene transcription was shown to contain sequences able to respond to CD69 cross-linking, by enhancing by about 100% a phorbol 12-myristate 13-acetate (PMA)-plus-ionomycin stimulation of CAT activity.	Tetradecanoylphorbol Acetate	229-232	CD69 molecule	Homo sapiens	147-151
7903158-8	1993	Stimulation with anti-CD28 mAb in conjunction with phorbol myristate acetate and ionomycin promotes cell cycling in the CD2- subset of CD4-CD8- T cells, and results in a slight induction of CD2 levels during the course of the culture period.	Tetradecanoylphorbol Acetate	51-76	CD2 antigen	Mus musculus	22-25
7903158-8	1993	Stimulation with anti-CD28 mAb in conjunction with phorbol myristate acetate and ionomycin promotes cell cycling in the CD2- subset of CD4-CD8- T cells, and results in a slight induction of CD2 levels during the course of the culture period.	Tetradecanoylphorbol Acetate	51-76	CD2 antigen	Mus musculus	120-123
8249125-6	1993	However, at therapeutic concentrations (0.1-5 micrograms/ml) vWF release by cells stimulated with thrombin, histamine, PMA, and the calcium ionophore A23187 was enhanced by both CsA and cremophor in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	119-122	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	178-181
8223588-9	1993	After exposure to phorbol 12-myristate 13-acetate, a complete depletion of PKC-beta was observed within 1 h and the complete depletion of PKC-alpha and PKC-delta isotypes was observed within 4 h. In contrast, PKC-epsilon was only partially down-regulated after a 24-h treatment with phorbol 12-myristate 13-acetate and PKC-zeta was not affected at all.	Tetradecanoylphorbol Acetate	18-49	protein kinase C, beta	Mus musculus	75-83
8223588-9	1993	After exposure to phorbol 12-myristate 13-acetate, a complete depletion of PKC-beta was observed within 1 h and the complete depletion of PKC-alpha and PKC-delta isotypes was observed within 4 h. In contrast, PKC-epsilon was only partially down-regulated after a 24-h treatment with phorbol 12-myristate 13-acetate and PKC-zeta was not affected at all.	Tetradecanoylphorbol Acetate	18-49	protein kinase C, epsilon	Mus musculus	209-220
8276128-4	1993	Secretion of granzyme A by LAK cells was triggered by 12-O-tetradecanoylphorbol 13-acetate and the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	54-90	granzyme A	Homo sapiens	13-23
8297418-7	1993	Immunohistochemical analysis indicated that the abnormal neurites in the areas of denervation and PMA administration were positive with antisynaptophysin and antigrowth-associated protein 43 (GAP-43), with an increased APP immunoreactivity surrounding them.	Tetradecanoylphorbol Acetate	98-101	growth associated protein 43	Rattus norvegicus	192-198
8373383-0	1993	Increment of the cyclin D1 mRNA level in TPA-treated three human myeloid leukemia cell lines: HEL, CMK and HL-60 cells.	Tetradecanoylphorbol Acetate	41-44	cyclin D1	Homo sapiens	17-26
8373383-2	1993	Unexpectedly, the cyclin D1 mRNA level markedly increased in the HEL cells when the cells were growth-arrested by TPA, while the amounts of cyclin E and A mRNAs decreased to an almost undetectable level in HEL cells after incubation with TPA.	Tetradecanoylphorbol Acetate	114-117	cyclin D1	Homo sapiens	18-27
8373383-3	1993	The similar marked increment of the cyclin D1 mRNA level was observed in other leukemia cell lines, CMK and HL-60 cells, after incubation with TPA.	Tetradecanoylphorbol Acetate	143-146	cyclin D1	Homo sapiens	36-45
8396935-4	1993	Phorbol myristate acetate (PMA), another activator of EL4.NOB-1 cells, had an opposite effect to IL-1 in that it increased binding site expression dramatically suggesting different mechanisms of action for these two effectors.	Tetradecanoylphorbol Acetate	0-25	interleukin 1 complex	Mus musculus	97-101
8081876-3	1993	EGF-induced phosphorylation and communication inhibition were retained in cells pretreated with phorbol 12-myristate 13-acetate (PMA) to deplete protein kinase C. These results show that the EGF inhibition of communication is tightly linked to protein kinase C-independent phosphorylation of Cx43.	Tetradecanoylphorbol Acetate	96-127	gap junction protein alpha 1	Homo sapiens	292-296
8081876-3	1993	EGF-induced phosphorylation and communication inhibition were retained in cells pretreated with phorbol 12-myristate 13-acetate (PMA) to deplete protein kinase C. These results show that the EGF inhibition of communication is tightly linked to protein kinase C-independent phosphorylation of Cx43.	Tetradecanoylphorbol Acetate	129-132	gap junction protein alpha 1	Homo sapiens	292-296
8359233-10	1993	Taken together, our results suggest the existence of a labile mRNA regulatory protein or proteins, whose actions include destabilization of both c-fms and CSF-1 transcripts after inhibition of TPA-induced monocytic differentiation by dex or CsA.	Tetradecanoylphorbol Acetate	193-196	colony stimulating factor 1 receptor	Homo sapiens	145-150
8344255-1	1993	The trans-acting factor AP-1 is a heterodimeric complex composed of c-Jun and c-Fos family proteins which bind and regulate genes containing a TPA responsive enhancer element.	Tetradecanoylphorbol Acetate	143-146	jun proto-oncogene	Mus musculus	24-28
8344255-1	1993	The trans-acting factor AP-1 is a heterodimeric complex composed of c-Jun and c-Fos family proteins which bind and regulate genes containing a TPA responsive enhancer element.	Tetradecanoylphorbol Acetate	143-146	jun proto-oncogene	Mus musculus	68-73
8101106-7	1993	Furthermore, the p65 antisense oligomer effectively abolished an upregulation of CD11b that was produced by formyl-met-leu-phe and TPA.	Tetradecanoylphorbol Acetate	131-134	RELA proto-oncogene, NF-kB subunit	Homo sapiens	17-20
8325838-4	1993	Time- and calcium-dependent vesiculation of platelets in response to ADP, collagen, thrombin, phorbol myristate acetate, and the thrombin peptide SFLLRN were dramatically inhibited, in a concentration-dependent manner, by monoclonal antibodies to GPIIb-IIIa (A2A9, 7E3, PAC1) and RGDS.	Tetradecanoylphorbol Acetate	94-119	dual specificity phosphatase 2	Homo sapiens	270-274
8325838-4	1993	Time- and calcium-dependent vesiculation of platelets in response to ADP, collagen, thrombin, phorbol myristate acetate, and the thrombin peptide SFLLRN were dramatically inhibited, in a concentration-dependent manner, by monoclonal antibodies to GPIIb-IIIa (A2A9, 7E3, PAC1) and RGDS.	Tetradecanoylphorbol Acetate	94-119	ral guanine nucleotide dissociation stimulator	Homo sapiens	280-284
8392062-2	1993	J774 cells responded to either phorbol 12-myristate 13-acetate (PMA) or LPS by the transient increase in the expression levels of c-jun and junB mRNA, but not of junD mRNA.	Tetradecanoylphorbol Acetate	31-62	jun proto-oncogene	Mus musculus	130-135
8392062-2	1993	J774 cells responded to either phorbol 12-myristate 13-acetate (PMA) or LPS by the transient increase in the expression levels of c-jun and junB mRNA, but not of junD mRNA.	Tetradecanoylphorbol Acetate	64-67	jun proto-oncogene	Mus musculus	130-135
8325942-9	1993	In cells that were pretreated with E2 (50 nM) for 48 h before treatment (18 h) with ET-1, TNF alpha, tetradecanoylphorbol acetate, and TGF beta 1, the production of PTH-rP was greater than that in cells not pretreated with estrogen.	Tetradecanoylphorbol Acetate	101-129	parathyroid hormone like hormone	Homo sapiens	165-171
8410828-3	1993	Exposure to PMA over 48 h resulted in a significant increase in MMP-1 activity but only a modest and nonsignificant increase in MMP-2 activity.	Tetradecanoylphorbol Acetate	12-15	matrix metallopeptidase 2	Homo sapiens	128-133
8389756-8	1993	Treatment with 4 beta-phorbol 12-myristate 13-acetate of cells transfected with the type 2 enzyme cDNA resulted in a 2-fold increase of the hCG-stimulated cAMP accumulation and a complete suppression of the Q205LGi2-alpha inhibition of the type 2 adenylyl cyclase.	Tetradecanoylphorbol Acetate	15-53	hypertrichosis 2 (generalised, congenital)	Homo sapiens	140-143
1335700-3	1992	When PMA was incubated together with PMN (PMN/EC = 1.25:1 or 2.5 x 10(5) neutrophils/ml) for 4 h in Earle"s salts, a PMA dose-dependent decrease in ACE activity was observed.	Tetradecanoylphorbol Acetate	5-8	angiotensin-converting enzyme	Oryctolagus cuniculus	148-151
1335700-7	1992	Inhibition of ACE occurred as early as 1 h after incubation (PMA 10 ng/ml, PMN/EC = 1.25:1).	Tetradecanoylphorbol Acetate	61-64	angiotensin-converting enzyme	Oryctolagus cuniculus	14-17
1332852-6	1992	The increase in both 80K protein phosphorylation and hPL release in response to apoAI was prevented by pretreatment of the cells with the PKC inhibitor staurosporine (10 microM) or by down-regulation of PKC after extended preincubation of the cells with 16 microM PMA.	Tetradecanoylphorbol Acetate	264-267	galectin 1	Homo sapiens	53-56
1333514-11	1992	Despite the absence of increased plasma membrane protein kinase C activity up to 4 hours after interleukin 1, pretreatment of human umbilical vein endothelium monolayers with staurosporine or phorbol myristate acetate (18 hours) to reduce protein kinase C activities, significantly attenuated the interleukin 1-stimulated prostanoid responses at 16 hours but not at 4 hours.	Tetradecanoylphorbol Acetate	192-217	interleukin 1 alpha	Homo sapiens	297-310
1333514-12	1992	Furthermore, short (5 minute) pretreatment with phorbol myristate acetate dramatically augmented interleukin 1-mediated prostacyclin responses in synergistic fashion, suggesting that protein kinase C may modulate interleukin 1 signal transducing pathways.	Tetradecanoylphorbol Acetate	48-73	interleukin 1 alpha	Homo sapiens	97-110
1333514-12	1992	Furthermore, short (5 minute) pretreatment with phorbol myristate acetate dramatically augmented interleukin 1-mediated prostacyclin responses in synergistic fashion, suggesting that protein kinase C may modulate interleukin 1 signal transducing pathways.	Tetradecanoylphorbol Acetate	48-73	interleukin 1 alpha	Homo sapiens	213-226
1336558-5	1992	Serum as well as 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulated NGF and all 4 BDNF mRNAs in L929 cells.	Tetradecanoylphorbol Acetate	17-54	brain derived neurotrophic factor	Mus musculus	86-90
1336558-5	1992	Serum as well as 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulated NGF and all 4 BDNF mRNAs in L929 cells.	Tetradecanoylphorbol Acetate	56-59	brain derived neurotrophic factor	Mus musculus	86-90
1454064-4	1992	Treatment of immature lymphocytes with TPA caused the specific and rapid elimination of steady-state RAG-1 and RAG-2 RNA.	Tetradecanoylphorbol Acetate	39-42	recombination activating 1	Homo sapiens	101-106
1454064-4	1992	Treatment of immature lymphocytes with TPA caused the specific and rapid elimination of steady-state RAG-1 and RAG-2 RNA.	Tetradecanoylphorbol Acetate	39-42	recombination activating 2	Homo sapiens	111-116
1454064-5	1992	Nuclear run-on assays showed that TPA completely repressed the transcription of RAG-1 within 30 min.	Tetradecanoylphorbol Acetate	34-37	recombination activating 1	Homo sapiens	80-85
1454064-6	1992	In addition to repressing the transcription of RAG-1, TPA treatment caused the rapid and specific degradation of RAG-1 transcripts by decreasing the apparent half-life of RAG-1 mRNA more than two-fold.	Tetradecanoylphorbol Acetate	54-57	recombination activating 1	Homo sapiens	47-52
1454064-6	1992	In addition to repressing the transcription of RAG-1, TPA treatment caused the rapid and specific degradation of RAG-1 transcripts by decreasing the apparent half-life of RAG-1 mRNA more than two-fold.	Tetradecanoylphorbol Acetate	54-57	recombination activating 1	Homo sapiens	113-118
1454064-6	1992	In addition to repressing the transcription of RAG-1, TPA treatment caused the rapid and specific degradation of RAG-1 transcripts by decreasing the apparent half-life of RAG-1 mRNA more than two-fold.	Tetradecanoylphorbol Acetate	54-57	recombination activating 1	Homo sapiens	113-118
1454064-8	1992	A labile transcriptional repressor, separate from the TPA-associated repression of transcription, was also active in cells transcribing RAG-1 and RAG-2 RNA.	Tetradecanoylphorbol Acetate	54-57	recombination activating 1	Homo sapiens	136-141
1454064-8	1992	A labile transcriptional repressor, separate from the TPA-associated repression of transcription, was also active in cells transcribing RAG-1 and RAG-2 RNA.	Tetradecanoylphorbol Acetate	54-57	recombination activating 2	Homo sapiens	146-151
1454064-9	1992	After depletion of this labile repressor by cycloheximide treatment, steady-state RAG-1 and RAG-2 RNA levels, and their transcription rates, were elevated four- to six-fold; but were still susceptible to elimination by TPA treatment.	Tetradecanoylphorbol Acetate	219-222	recombination activating 1	Homo sapiens	82-87
1454064-9	1992	After depletion of this labile repressor by cycloheximide treatment, steady-state RAG-1 and RAG-2 RNA levels, and their transcription rates, were elevated four- to six-fold; but were still susceptible to elimination by TPA treatment.	Tetradecanoylphorbol Acetate	219-222	recombination activating 2	Homo sapiens	92-97
1280163-0	1992	A lymphocyte-specific protein tyrosine kinase, p56lck, regulates the PMA-induced internalization of CD4.	Tetradecanoylphorbol Acetate	69-72	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	47-53
1358967-8	1992	In functional assays, IL-4 production could only be induced in CD45RA-CD27- CD4 clones by stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	107-110	CD27 molecule	Homo sapiens	70-74
1443103-0	1992	Interaction of TPA and ultraviolet B radiation in regulation of ODC gene expression in rat keratinocytes.	Tetradecanoylphorbol Acetate	15-18	ornithine decarboxylase 1	Rattus norvegicus	64-67
1443103-2	1992	To define the interaction of UVB and phorbol esters in the control of keratinocyte gene expression, we have studied the effects of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and UVB on the regulation of ornithine decarboxylase (ODC) gene expression in a rat keratinocyte cell line.	Tetradecanoylphorbol Acetate	149-185	ornithine decarboxylase 1	Rattus norvegicus	221-244
1443103-3	1992	Both UVB and TPA alone increased ODC activity and induced the expression of the ODC gene.	Tetradecanoylphorbol Acetate	13-16	ornithine decarboxylase 1	Rattus norvegicus	33-36
1443103-3	1992	Both UVB and TPA alone increased ODC activity and induced the expression of the ODC gene.	Tetradecanoylphorbol Acetate	13-16	ornithine decarboxylase 1	Rattus norvegicus	80-83
1443103-4	1992	The combination of UVB and TPA produced a further increment in ODC gene expression at 12 h, but UVB markedly attenuated the TPA induction of ODC mRNA transcripts at 3 h. Protein synthesis inhibition with cycloheximide also induced ODC mRNA transcripts, but did not eliminate the further induction of ODC gene expression by UVB or TPA.	Tetradecanoylphorbol Acetate	27-30	ornithine decarboxylase 1	Rattus norvegicus	63-66
1443103-4	1992	The combination of UVB and TPA produced a further increment in ODC gene expression at 12 h, but UVB markedly attenuated the TPA induction of ODC mRNA transcripts at 3 h. Protein synthesis inhibition with cycloheximide also induced ODC mRNA transcripts, but did not eliminate the further induction of ODC gene expression by UVB or TPA.	Tetradecanoylphorbol Acetate	124-127	ornithine decarboxylase 1	Rattus norvegicus	141-144
1443103-4	1992	The combination of UVB and TPA produced a further increment in ODC gene expression at 12 h, but UVB markedly attenuated the TPA induction of ODC mRNA transcripts at 3 h. Protein synthesis inhibition with cycloheximide also induced ODC mRNA transcripts, but did not eliminate the further induction of ODC gene expression by UVB or TPA.	Tetradecanoylphorbol Acetate	124-127	ornithine decarboxylase 1	Rattus norvegicus	141-144
1443103-4	1992	The combination of UVB and TPA produced a further increment in ODC gene expression at 12 h, but UVB markedly attenuated the TPA induction of ODC mRNA transcripts at 3 h. Protein synthesis inhibition with cycloheximide also induced ODC mRNA transcripts, but did not eliminate the further induction of ODC gene expression by UVB or TPA.	Tetradecanoylphorbol Acetate	124-127	ornithine decarboxylase 1	Rattus norvegicus	141-144
1443103-4	1992	The combination of UVB and TPA produced a further increment in ODC gene expression at 12 h, but UVB markedly attenuated the TPA induction of ODC mRNA transcripts at 3 h. Protein synthesis inhibition with cycloheximide also induced ODC mRNA transcripts, but did not eliminate the further induction of ODC gene expression by UVB or TPA.	Tetradecanoylphorbol Acetate	124-127	ornithine decarboxylase 1	Rattus norvegicus	141-144
1443103-4	1992	The combination of UVB and TPA produced a further increment in ODC gene expression at 12 h, but UVB markedly attenuated the TPA induction of ODC mRNA transcripts at 3 h. Protein synthesis inhibition with cycloheximide also induced ODC mRNA transcripts, but did not eliminate the further induction of ODC gene expression by UVB or TPA.	Tetradecanoylphorbol Acetate	124-127	ornithine decarboxylase 1	Rattus norvegicus	141-144
1443103-4	1992	The combination of UVB and TPA produced a further increment in ODC gene expression at 12 h, but UVB markedly attenuated the TPA induction of ODC mRNA transcripts at 3 h. Protein synthesis inhibition with cycloheximide also induced ODC mRNA transcripts, but did not eliminate the further induction of ODC gene expression by UVB or TPA.	Tetradecanoylphorbol Acetate	124-127	ornithine decarboxylase 1	Rattus norvegicus	141-144
1443149-6	1992	Treatment of quiescent cultures with PMA induced a maximal 400% increase in ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	37-40	ornithine decarboxylase 1	Rattus norvegicus	76-99
1443149-6	1992	Treatment of quiescent cultures with PMA induced a maximal 400% increase in ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	37-40	ornithine decarboxylase 1	Rattus norvegicus	101-104
1443885-6	1992	Both lung macrophages and blood neutrophils from animals exposed to aerosolized GM-CSF exhibited an augmented respiratory burst in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	143-168	colony stimulating factor 2	Homo sapiens	80-86
1283312-0	1992	Differential phosphorylation of CK8 and CK18 by 12-O-tetradecanoyl-phorbol-13-acetate in primary cultures of mouse hepatocytes.	Tetradecanoylphorbol Acetate	48-85	keratin 8	Mus musculus	32-35
1283312-3	1992	Treatment of the hepatocytes with 150 nM 12-O-tetradecanoyl-phorbol-13-acetate (TPA) an activator of protein kinase C induced a transient increase in the level of phosphorylation of CK8 but not CK18.	Tetradecanoylphorbol Acetate	41-78	keratin 8	Mus musculus	182-185
1283312-3	1992	Treatment of the hepatocytes with 150 nM 12-O-tetradecanoyl-phorbol-13-acetate (TPA) an activator of protein kinase C induced a transient increase in the level of phosphorylation of CK8 but not CK18.	Tetradecanoylphorbol Acetate	80-83	keratin 8	Mus musculus	182-185
1283312-4	1992	This effect was maximal after 15 min of TPA treatment and was maintained for up to 3 h. After 22 h of treatment with TPA, which down-regulates protein kinase C, CK8 phosphorylation was returned to the basal level.	Tetradecanoylphorbol Acetate	40-43	keratin 8	Mus musculus	161-164
1283312-4	1992	This effect was maximal after 15 min of TPA treatment and was maintained for up to 3 h. After 22 h of treatment with TPA, which down-regulates protein kinase C, CK8 phosphorylation was returned to the basal level.	Tetradecanoylphorbol Acetate	117-120	keratin 8	Mus musculus	161-164
1283312-6	1992	Indirect immunofluorescence microscopy with a monoclonal antibody to CK8 indicated that while the addition of TPA induced the formation of granular cytokeratin aggregates in some hepatocytes, in most hepatocytes no major changes in the intermediate filament network were observed.	Tetradecanoylphorbol Acetate	110-113	keratin 8	Mus musculus	69-72
1472905-3	1992	This report describes the sequential changes in the expression of four proto-oncogenes, c-fos, c-myc, c-sis and H-ras in DMEC following PMA exposure.	Tetradecanoylphorbol Acetate	136-139	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	95-100
1472905-3	1992	This report describes the sequential changes in the expression of four proto-oncogenes, c-fos, c-myc, c-sis and H-ras in DMEC following PMA exposure.	Tetradecanoylphorbol Acetate	136-139	HRas proto-oncogene, GTPase	Homo sapiens	112-117
8333537-1	1993	T84 adenocarcinoma cells were stimulated to secrete mucin by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and Ca2+ ionophores A23187 and ionomycin.	Tetradecanoylphorbol Acetate	79-110	LOC100508689	Homo sapiens	52-57
8333537-1	1993	T84 adenocarcinoma cells were stimulated to secrete mucin by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and Ca2+ ionophores A23187 and ionomycin.	Tetradecanoylphorbol Acetate	112-115	LOC100508689	Homo sapiens	52-57
1425916-8	1992	Rather, PMA blocked the IL-3 effect on C5a-induced LTC4 synthesis.	Tetradecanoylphorbol Acetate	8-11	interleukin 3	Homo sapiens	24-28
8502244-1	1993	The cell surface expression of the CD32 receptors for the Fc portion of immunoglobulin G (Fc gamma RII-CD32) is regulated by agents such as phorbol esters (PMA) and cytokines.	Tetradecanoylphorbol Acetate	156-159	Fc gamma receptor IIa	Homo sapiens	35-39
8502244-1	1993	The cell surface expression of the CD32 receptors for the Fc portion of immunoglobulin G (Fc gamma RII-CD32) is regulated by agents such as phorbol esters (PMA) and cytokines.	Tetradecanoylphorbol Acetate	156-159	Fc gamma receptor IIa	Homo sapiens	103-107
9377579-0	1997	Re-expression of elafin in 21MT2 breast carcinomas by phorbol 12-myristate 13-acetate is mediated by the Ap1 site in the elafin promoter.	Tetradecanoylphorbol Acetate	54-85	peptidase inhibitor 3	Homo sapiens	17-23
1331121-11	1992	We have taken advantage of the different sensitivities of phospholipases A2 and C(s) to PMA, EGTA, and pertussis toxin to dissociate phospholipase A2 and C activities.	Tetradecanoylphorbol Acetate	88-91	phospholipase A2 group IB	Rattus norvegicus	133-149
9377579-4	1997	By deletion analysis and mutagenesis, we have identified the Ap1 site in the promoter as the cis element mediating transcriptional activation of elafin in 70N normal breast cells and its induction by phorbol 12-myristate 13-acetate (PMA) in 21MT2 breast tumors.	Tetradecanoylphorbol Acetate	233-236	peptidase inhibitor 3	Homo sapiens	145-151
9316415-5	1997	Treatment with PMA for 30 min increased PKC activity in subcellular fractions and induced a redistribution of PKC-beta II and -delta to a particulate fraction.	Tetradecanoylphorbol Acetate	15-18	protein kinase C delta	Homo sapiens	110-132
1357034-8	1992	Ocular cells were also stimulated with PMA and shown to produce IL-1.	Tetradecanoylphorbol Acetate	39-42	interleukin 1 alpha	Homo sapiens	64-68
8478959-4	1993	PURPOSE: A randomized phase I study of DFMO was conducted to determine the lowest daily oral dose that can achieve at least 50% inhibition of ODC activity induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in human skin, with minimal clinical toxicity (grade 1 or lower; Eastern Cooperative Oncology Group [ECOG]).	Tetradecanoylphorbol Acetate	166-202	ornithine decarboxylase 1	Homo sapiens	142-145
8478959-4	1993	PURPOSE: A randomized phase I study of DFMO was conducted to determine the lowest daily oral dose that can achieve at least 50% inhibition of ODC activity induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in human skin, with minimal clinical toxicity (grade 1 or lower; Eastern Cooperative Oncology Group [ECOG]).	Tetradecanoylphorbol Acetate	204-207	ornithine decarboxylase 1	Homo sapiens	142-145
8478959-10	1993	To evaluate the effectiveness of DFMO in reducing TPA-induced ODC activity, we calculated the percent change from pretreatment ODC levels in skin biopsy specimens and the percentage of subjects with at least a 50% reduction in ODC levels.	Tetradecanoylphorbol Acetate	50-53	ornithine decarboxylase 1	Homo sapiens	62-65
1337129-4	1992	ULN suppressed formylmethionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA)-induced superoxide production from polymorphonuclear leukocytes (PMNs) as measured by the cytochrome c assay.	Tetradecanoylphorbol Acetate	63-88	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	0-3
1337129-4	1992	ULN suppressed formylmethionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA)-induced superoxide production from polymorphonuclear leukocytes (PMNs) as measured by the cytochrome c assay.	Tetradecanoylphorbol Acetate	90-93	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	0-3
9262511-3	1997	We have previously shown in myelomonocytic HL-60 cells that phorbol myristate acetate (PMA) upregulates c-fms mRNA expression.	Tetradecanoylphorbol Acetate	60-85	colony stimulating factor 1 receptor	Homo sapiens	104-109
8509141-5	1993	Activation of peripheral blood T cells with phytohaemagglutinin (PHA), or phorbol myristate acetate (PMA) and calcium ionophore (CaI) led to a decrease in the proportion of CMRF-35+ T lymphocytes.	Tetradecanoylphorbol Acetate	74-99	CD300c molecule	Homo sapiens	173-180
9262511-3	1997	We have previously shown in myelomonocytic HL-60 cells that phorbol myristate acetate (PMA) upregulates c-fms mRNA expression.	Tetradecanoylphorbol Acetate	87-90	colony stimulating factor 1 receptor	Homo sapiens	104-109
8473314-2	1993	Basal gag protein phosphorylation was inhibited up to 75% with the PKC inhibitor, H-7, and stimulated 3-4-fold with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	116-147	Pr55(Gag)	Human immunodeficiency virus 1	6-9
1417981-3	1992	We also demonstrated that this glucocorticoid inhibits TPA-induced increases in expression of the EGR-1 early response gene.	Tetradecanoylphorbol Acetate	55-58	early growth response 1	Homo sapiens	98-103
9299372-8	1997	Furthermore, FSK and TPA synergistically activated Raf-1.	Tetradecanoylphorbol Acetate	21-24	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	51-56
1384479-5	1992	The tumor promoter, tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the stimulatory effect of IL-1 alpha and IL-1 beta on the production of HGF.	Tetradecanoylphorbol Acetate	53-56	interleukin 1 alpha	Homo sapiens	102-112
7681399-2	1993	Treatment of these cells with human recombinant human tumor necrosis factor (TNF) resulted in an increase in phagocytosis and phorbol myristate acetate-stimulated superoxide anion production at 12 h and growth retardation occurring at 24 h. Moreover, TNF induced a moderate increase of CD14 surface antigen expression, used as a phenotypic marker of monocyte/macrophage differentiation.	Tetradecanoylphorbol Acetate	126-151	CD14 molecule	Homo sapiens	286-290
8495968-11	1993	However, the levels of IL-4 mRNA, detected in ionomycin and PMA-stimulated splenocytes using a quantitative polymerase chain reaction (PCR) procedure, were three- to fourfold higher in ricin and antigen immunized animals as compared with control animals.	Tetradecanoylphorbol Acetate	60-63	interleukin 4	Rattus norvegicus	23-27
9328432-3	1997	The PA2.26 protein was also expressed in basal-like cells of differentiated papillomas and carcinomas generated in mice treated with DMBA and TPA.	Tetradecanoylphorbol Acetate	142-145	podoplanin	Homo sapiens	4-10
1357974-5	1992	The expression of TM in MS-1 cells was increased markedly when these cells were induced by 12-0-tetradecanyl phorbol 13-acetate (TPA) to differentiate.	Tetradecanoylphorbol Acetate	129-132	thrombomodulin	Homo sapiens	18-20
9270030-8	1997	Supershift electrophoresis mobility shift assay revealed that Jun B and c-Jun were absent from the AP-1/DNA complex following TNF-alpha but present following TPA treatment.	Tetradecanoylphorbol Acetate	158-161	jun proto-oncogene	Mus musculus	72-77
1424560-2	1992	Lymphocytes from cats &gt; or = 20 weeks old released significantly more interleukin 2 than those obtained from these cats at earlier ages when stimulated with calcium ionophore A23187 and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	189-214	interleukin 2	Felis catus	73-86
1327718-4	1992	In transfected COS-1 cells, TRH and phorbol 12-myristate 13-acetate (PMA) caused increases in the level of TRH-R mRNA.	Tetradecanoylphorbol Acetate	36-67	thyrotropin releasing hormone receptor	Rattus norvegicus	107-112
8462673-6	1993	TPA strongly induced PGHS-2 protein and also increased the amount of PGHS-1 protein.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	21-27
8384125-3	1993	Protein kinase C (PKC) is known to couple membrane activity to AChR gene inactivation; myogenin gene transcription was also rapidly blocked by the PKC activator PMA, whereas electrostimulation remained without effect on myogenin gene activity in muscle that was either exposed to the kinase inhibitor staurosporine or chronically treated with PMA to deplete PKC.	Tetradecanoylphorbol Acetate	161-164	myogenin	Gallus gallus	87-95
8384125-3	1993	Protein kinase C (PKC) is known to couple membrane activity to AChR gene inactivation; myogenin gene transcription was also rapidly blocked by the PKC activator PMA, whereas electrostimulation remained without effect on myogenin gene activity in muscle that was either exposed to the kinase inhibitor staurosporine or chronically treated with PMA to deplete PKC.	Tetradecanoylphorbol Acetate	343-346	myogenin	Gallus gallus	87-95
1327718-4	1992	In transfected COS-1 cells, TRH and phorbol 12-myristate 13-acetate (PMA) caused increases in the level of TRH-R mRNA.	Tetradecanoylphorbol Acetate	69-72	thyrotropin releasing hormone receptor	Rattus norvegicus	107-112
9266828-4	1997	When over-expressed by transient transfection, SMRT inhibits MMP-1 promoter activity induced by interleukin-1 (IL-1), phorbol phorbol myristate acetate (PMA) or v-Src.	Tetradecanoylphorbol Acetate	153-156	nuclear receptor corepressor 2	Homo sapiens	47-51
1517222-5	1992	The HL-60 myeloblast leukemia cell line expressed higher LTC4 synthase levels when differentiated into either neutrophil-like or macrophage-like cells by growth in the presence of dimethyl sulfoxide or phorbol 12-myristate 13-acetate (respectively), but reached a specific activity comparable only to undifferentiated U937 cells.	Tetradecanoylphorbol Acetate	202-233	leukotriene C4 synthase	Homo sapiens	57-70
1333725-3	1992	An increase of phorbol-myristate-acetate- and formyl-methionyl-leucyl-phenylalanine-stimulated superoxide production of monocytes cultured with interleukin-3 compared to control cells was detected first after 24 h of monocyte culture.	Tetradecanoylphorbol Acetate	15-40	interleukin 3	Homo sapiens	144-157
1417179-8	1992	The tumor-promoting phorbol ester (phorbol 12-myristate 13-acetate [PMA]), known to induce jun and fos gene expression, caused increases in jun-B and fos-B that preceded the decrease in albumin mRNA levels at 24 hours.	Tetradecanoylphorbol Acetate	35-66	FBJ osteosarcoma oncogene	Mus musculus	99-102
1417179-8	1992	The tumor-promoting phorbol ester (phorbol 12-myristate 13-acetate [PMA]), known to induce jun and fos gene expression, caused increases in jun-B and fos-B that preceded the decrease in albumin mRNA levels at 24 hours.	Tetradecanoylphorbol Acetate	35-66	jun B proto-oncogene	Mus musculus	140-145
1417179-8	1992	The tumor-promoting phorbol ester (phorbol 12-myristate 13-acetate [PMA]), known to induce jun and fos gene expression, caused increases in jun-B and fos-B that preceded the decrease in albumin mRNA levels at 24 hours.	Tetradecanoylphorbol Acetate	35-66	FBJ osteosarcoma oncogene	Mus musculus	150-153
1417179-8	1992	The tumor-promoting phorbol ester (phorbol 12-myristate 13-acetate [PMA]), known to induce jun and fos gene expression, caused increases in jun-B and fos-B that preceded the decrease in albumin mRNA levels at 24 hours.	Tetradecanoylphorbol Acetate	68-71	FBJ osteosarcoma oncogene	Mus musculus	99-102
8334226-2	1993	In T lymphocytes all genes: platelet basic protein (PBP); platelet factor 4 (PF-4); IL-8/NAP-1; IP-10; GRO; pAT464 and pAT744 were induced by stimulation with phytohemagglutinin and phorbol 12-myristate 13-acetate (PHA/PMA).	Tetradecanoylphorbol Acetate	182-213	pro-platelet basic protein	Homo sapiens	28-50
7680355-7	1993	After treatment with phorbol 12-myristate 13-acetate (10(-7) M) for 7 days, there was an increase in the mRNA for CgB and SgII mRNAs in GH and null cell tumors, while dexamethasone treatment for 7 days increased CgA mRNA in GH and null cell adenomas.	Tetradecanoylphorbol Acetate	21-52	chromogranin B	Homo sapiens	114-117
7680355-7	1993	After treatment with phorbol 12-myristate 13-acetate (10(-7) M) for 7 days, there was an increase in the mRNA for CgB and SgII mRNAs in GH and null cell tumors, while dexamethasone treatment for 7 days increased CgA mRNA in GH and null cell adenomas.	Tetradecanoylphorbol Acetate	21-52	secretogranin II	Homo sapiens	122-126
8436813-7	1993	Consistent with this, overnight treatment with PMA caused down-regulation of both PKC delta and epsilon, but to a lesser degree than was observed with PKC beta.	Tetradecanoylphorbol Acetate	47-50	protein kinase C delta	Homo sapiens	82-91
8436813-7	1993	Consistent with this, overnight treatment with PMA caused down-regulation of both PKC delta and epsilon, but to a lesser degree than was observed with PKC beta.	Tetradecanoylphorbol Acetate	47-50	protein kinase C beta	Homo sapiens	151-159
8381095-4	1993	PMA or PE also increased MBP kinase (4- or 2.5-fold, respectively).	Tetradecanoylphorbol Acetate	0-3	myelin basic protein	Homo sapiens	25-28
8425569-3	1993	Exposure of the TcR-alpha mRNA negative subclones to phorbol 12-myristate 13-acetate (PMA) was followed by 2- to 3-fold increase of transcription, indicating that PMA acts on a transcriptional level.	Tetradecanoylphorbol Acetate	53-84	T cell receptor alpha constant	Homo sapiens	16-25
1417179-8	1992	The tumor-promoting phorbol ester (phorbol 12-myristate 13-acetate [PMA]), known to induce jun and fos gene expression, caused increases in jun-B and fos-B that preceded the decrease in albumin mRNA levels at 24 hours.	Tetradecanoylphorbol Acetate	68-71	jun B proto-oncogene	Mus musculus	140-145
1417179-8	1992	The tumor-promoting phorbol ester (phorbol 12-myristate 13-acetate [PMA]), known to induce jun and fos gene expression, caused increases in jun-B and fos-B that preceded the decrease in albumin mRNA levels at 24 hours.	Tetradecanoylphorbol Acetate	68-71	FBJ osteosarcoma oncogene	Mus musculus	150-153
8425569-3	1993	Exposure of the TcR-alpha mRNA negative subclones to phorbol 12-myristate 13-acetate (PMA) was followed by 2- to 3-fold increase of transcription, indicating that PMA acts on a transcriptional level.	Tetradecanoylphorbol Acetate	86-89	T cell receptor alpha constant	Homo sapiens	16-25
9234795-5	1997	Thus, the specific competitive inhibitor of class I/II PKC, 1-O-hexadecyl-2-O-methyl-rac-glycerol (AMG), prevented only the action of PMA and LPS on HUVEC.	Tetradecanoylphorbol Acetate	134-137	amelogenin X-linked	Homo sapiens	99-102
8423794-5	1993	This effect is not observed when oocytes are incubated with phorbol myristate acetate or progesterone, both of which utilize a ras p21-independent pathway for oocyte activation.	Tetradecanoylphorbol Acetate	60-85	cyclin-dependent kinase inhibitor 1A L homeolog	Xenopus laevis	131-134
1419487-1	1992	The addition of granulocyte-macrophage colony-stimulating factor (GM-CSF) to human peripheral blood neutrophils primes phospholipase D (PLD) to subsequent stimulation by N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	220-245	colony stimulating factor 2	Homo sapiens	16-64
1419487-1	1992	The addition of granulocyte-macrophage colony-stimulating factor (GM-CSF) to human peripheral blood neutrophils primes phospholipase D (PLD) to subsequent stimulation by N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	220-245	colony stimulating factor 2	Homo sapiens	66-72
1419487-1	1992	The addition of granulocyte-macrophage colony-stimulating factor (GM-CSF) to human peripheral blood neutrophils primes phospholipase D (PLD) to subsequent stimulation by N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	247-250	colony stimulating factor 2	Homo sapiens	16-64
1419487-1	1992	The addition of granulocyte-macrophage colony-stimulating factor (GM-CSF) to human peripheral blood neutrophils primes phospholipase D (PLD) to subsequent stimulation by N-formyl-methionyl-leucyl-phenylalanine (fMLP) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	247-250	colony stimulating factor 2	Homo sapiens	66-72
8380829-2	1993	Although the formation of the cornified envelope is induced by tumor-promoting phorbol esters, the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the involucrin gene expression remains unknown.	Tetradecanoylphorbol Acetate	109-145	involucrin	Rattus norvegicus	159-169
9247295-5	1997	pp125FAK tyrosine phosphorylation was stimulated by bombesin and mimicked by PKC activation with the tumor-promotor phorbol 12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	116-147	protein tyrosine kinase 2	Homo sapiens	0-8
8380829-2	1993	Although the formation of the cornified envelope is induced by tumor-promoting phorbol esters, the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the involucrin gene expression remains unknown.	Tetradecanoylphorbol Acetate	147-150	involucrin	Rattus norvegicus	159-169
8380829-13	1993	These results indicate that involucrin gene expression is positively controlled by TPA through the activation of the protein kinase C/TRE system.	Tetradecanoylphorbol Acetate	83-86	involucrin	Rattus norvegicus	28-38
1380924-3	1992	c-fos mRNA was induced severalfold by 12-O-tetradecanoylphorbol-13-acetate (TPA) in both 10T1/2 and Cl 16.	Tetradecanoylphorbol Acetate	38-74	FBJ osteosarcoma oncogene	Mus musculus	0-5
1380924-3	1992	c-fos mRNA was induced severalfold by 12-O-tetradecanoylphorbol-13-acetate (TPA) in both 10T1/2 and Cl 16.	Tetradecanoylphorbol Acetate	76-79	FBJ osteosarcoma oncogene	Mus musculus	0-5
1380924-4	1992	Down-regulation of protein kinase C (PKC) activity by TPA pretreatment inhibited PDGF-stimulated c-fos mRNA expression in Cl 16 cells but did not affect this induction in the 10T1/2 cells.	Tetradecanoylphorbol Acetate	54-57	FBJ osteosarcoma oncogene	Mus musculus	97-102
7681292-5	1993	Previous studies have suggested that the induction of K13 in mouse skin is related to the mutation of the Ha-ras gene by the initiating agent DMBA, a mutation consistently found in murine DMBA/TPA-induced tumors and rarely found in human skin tumors.	Tetradecanoylphorbol Acetate	193-196	keratin 13	Mus musculus	54-57
9247295-5	1997	pp125FAK tyrosine phosphorylation was stimulated by bombesin and mimicked by PKC activation with the tumor-promotor phorbol 12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	149-152	protein tyrosine kinase 2	Homo sapiens	0-8
1323817-4	1992	Addition of platelet-derived growth factor (PDGF), 12-O-tetradecanoyl phorbol 13-acetate (TPA) or dibutyryl cyclic AMP (Bt2cAMP) to the control NIH3T3 cells stimulated c-fos-luciferase expression.	Tetradecanoylphorbol Acetate	51-88	FBJ osteosarcoma oncogene	Mus musculus	168-173
9272635-2	1997	The protein kinase C (PKC)-activating tumor promoters mezerein and phorbol 12-myristate 13-acetate (PMA), but not the inactive phorbol ester analog 4alpha-PMA, caused a pronounced decrease of myelin basic protein (MBP) content and 2",3"-cyclic nucleotide 3"-phosphohydrolase (CNP) activity.	Tetradecanoylphorbol Acetate	67-98	myelin basic protein	Homo sapiens	192-212
9272635-2	1997	The protein kinase C (PKC)-activating tumor promoters mezerein and phorbol 12-myristate 13-acetate (PMA), but not the inactive phorbol ester analog 4alpha-PMA, caused a pronounced decrease of myelin basic protein (MBP) content and 2",3"-cyclic nucleotide 3"-phosphohydrolase (CNP) activity.	Tetradecanoylphorbol Acetate	67-98	myelin basic protein	Homo sapiens	214-217
9272635-2	1997	The protein kinase C (PKC)-activating tumor promoters mezerein and phorbol 12-myristate 13-acetate (PMA), but not the inactive phorbol ester analog 4alpha-PMA, caused a pronounced decrease of myelin basic protein (MBP) content and 2",3"-cyclic nucleotide 3"-phosphohydrolase (CNP) activity.	Tetradecanoylphorbol Acetate	100-103	myelin basic protein	Homo sapiens	192-212
1322696-8	1992	HLA aggregation measured by FPR, FCET, and TPA was blocked by beta 2-microglobulin, b2m, added to the liposomes.	Tetradecanoylphorbol Acetate	43-46	beta-2-microglobulin	Homo sapiens	62-82
9272635-2	1997	The protein kinase C (PKC)-activating tumor promoters mezerein and phorbol 12-myristate 13-acetate (PMA), but not the inactive phorbol ester analog 4alpha-PMA, caused a pronounced decrease of myelin basic protein (MBP) content and 2",3"-cyclic nucleotide 3"-phosphohydrolase (CNP) activity.	Tetradecanoylphorbol Acetate	100-103	myelin basic protein	Homo sapiens	214-217
9201982-6	1997	Further, ligand blotting of glycoproteins isolated from phorbol 12-myristate 13-acetate-treated THP-1 cells or from transfected HepG2 and Chinese hamster ovary cells also provided evidence of increased binding of HDL3 to HB2.	Tetradecanoylphorbol Acetate	56-87	keratin 82	Homo sapiens	221-224
1502168-5	1992	Here we demonstrate that p56lck slows the rate of phorbol 12-myristate 13-acetate-induced internalization of CD4 in a manner that depends on a physical association between p56lck and CD4.	Tetradecanoylphorbol Acetate	50-81	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-31
9218873-8	1997	This TRE bound TPA induced specific nuclear complexes in vitro containing junD, c-jun, c-fos, and fra2 but not cAMP-responsive element binding/activating transcription factor family proteins.	Tetradecanoylphorbol Acetate	15-18	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-78
1502168-5	1992	Here we demonstrate that p56lck slows the rate of phorbol 12-myristate 13-acetate-induced internalization of CD4 in a manner that depends on a physical association between p56lck and CD4.	Tetradecanoylphorbol Acetate	50-81	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	172-178
9204988-6	1997	Activation of the cells with phorbol-12 myristate 13-acetate (PMA) up-regulates the expression of the CD69 activation antigen and down-regulates the CD117 molecule.	Tetradecanoylphorbol Acetate	29-60	CD69 molecule	Homo sapiens	102-106
9204988-6	1997	Activation of the cells with phorbol-12 myristate 13-acetate (PMA) up-regulates the expression of the CD69 activation antigen and down-regulates the CD117 molecule.	Tetradecanoylphorbol Acetate	62-65	CD69 molecule	Homo sapiens	102-106
9223624-5	1997	Phorbol 12-myristate 13-acetate (TPA) was found to enhance TSP-1 mRNA level whereas a protein kinase C inhibitor, H7, was shown to block the induction.	Tetradecanoylphorbol Acetate	0-31	thrombospondin 1	Rattus norvegicus	59-64
1526661-2	1992	Macrophage activation was accomplished by exposing inflammatory rat peritoneal macrophages to 10 units of IFN gamma for 72 h. IFN gamma treatment caused a four to fivefold increase in phorbol myristate acetate (PMA)-triggered H2O2 production, but Fc receptor phagocytic function was unaltered.	Tetradecanoylphorbol Acetate	211-214	interferon gamma	Rattus norvegicus	126-135
1526661-2	1992	Macrophage activation was accomplished by exposing inflammatory rat peritoneal macrophages to 10 units of IFN gamma for 72 h. IFN gamma treatment caused a four to fivefold increase in phorbol myristate acetate (PMA)-triggered H2O2 production, but Fc receptor phagocytic function was unaltered.	Tetradecanoylphorbol Acetate	184-209	interferon gamma	Rattus norvegicus	106-115
1526661-2	1992	Macrophage activation was accomplished by exposing inflammatory rat peritoneal macrophages to 10 units of IFN gamma for 72 h. IFN gamma treatment caused a four to fivefold increase in phorbol myristate acetate (PMA)-triggered H2O2 production, but Fc receptor phagocytic function was unaltered.	Tetradecanoylphorbol Acetate	184-209	interferon gamma	Rattus norvegicus	126-135
1526661-2	1992	Macrophage activation was accomplished by exposing inflammatory rat peritoneal macrophages to 10 units of IFN gamma for 72 h. IFN gamma treatment caused a four to fivefold increase in phorbol myristate acetate (PMA)-triggered H2O2 production, but Fc receptor phagocytic function was unaltered.	Tetradecanoylphorbol Acetate	211-214	interferon gamma	Rattus norvegicus	106-115
9223624-5	1997	Phorbol 12-myristate 13-acetate (TPA) was found to enhance TSP-1 mRNA level whereas a protein kinase C inhibitor, H7, was shown to block the induction.	Tetradecanoylphorbol Acetate	33-36	thrombospondin 1	Rattus norvegicus	59-64
9182808-13	1997	Our results indicate that keratolinin is identical with cystatin A, a cysteine proteinase inhibitor, and its expression is positively regulated by Ca2+, TPA, and forskolin.	Tetradecanoylphorbol Acetate	153-156	cystatin A	Homo sapiens	56-66
9178828-6	1997	These inhibitory effects of TPA and DG were antagonized by inhibitors of PKC such as H-7 and staurosporin, and by amiloride, an inhibitor of Na+/H+ antiporter.	Tetradecanoylphorbol Acetate	28-31	protein kinase C beta	Homo sapiens	73-76
1321269-1	1992	The Epstein-Barr virus BZLF1 protein that can induce the lytic cycle in latently infected cells is a transcription factor partially homologous to Fos and binds not only the canonical TPA (tetradecanoyl phorbol acetate)-responsive element (TRE) site but also sequences deviating from the TRE consensus sequence.	Tetradecanoylphorbol Acetate	183-186	protein Zta	Human gammaherpesvirus 4	23-28
1321269-1	1992	The Epstein-Barr virus BZLF1 protein that can induce the lytic cycle in latently infected cells is a transcription factor partially homologous to Fos and binds not only the canonical TPA (tetradecanoyl phorbol acetate)-responsive element (TRE) site but also sequences deviating from the TRE consensus sequence.	Tetradecanoylphorbol Acetate	188-217	protein Zta	Human gammaherpesvirus 4	23-28
9160089-7	1997	Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis.	Tetradecanoylphorbol Acetate	0-25	integrin subunit alpha X	Homo sapiens	98-103
1497680-3	1992	EROD activities in normal and TPA-treated epidermis paralleled steady state P450 CYP1A1 mRNA content.	Tetradecanoylphorbol Acetate	30-33	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	81-87
1497680-7	1992	These studies suggest that PKC participates in the processes associated with Cyp1a-1 induction and that TPA effects Cyp1a-1 induction through its down-regulation of PKC.	Tetradecanoylphorbol Acetate	104-107	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	116-123
9160089-7	1997	Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis.	Tetradecanoylphorbol Acetate	27-30	integrin subunit alpha L	Homo sapiens	84-89
9160089-7	1997	Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis.	Tetradecanoylphorbol Acetate	27-30	integrin subunit alpha X	Homo sapiens	98-103
1627333-9	1992	In contrast, phorbol 12-myristate 13-acetate (PMA) stimulated the level of spr1 mRNA by 3- to 8-fold.	Tetradecanoylphorbol Acetate	13-44	psoriasis susceptibility 1 candidate 2	Homo sapiens	75-79
9108029-7	1997	Phorbol 12-myristate 13 acetate efficiently translocated TRX into the HeLa cell nucleus where Ref-1 preexists.	Tetradecanoylphorbol Acetate	0-31	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	94-99
1627333-9	1992	In contrast, phorbol 12-myristate 13-acetate (PMA) stimulated the level of spr1 mRNA by 3- to 8-fold.	Tetradecanoylphorbol Acetate	46-49	psoriasis susceptibility 1 candidate 2	Homo sapiens	75-79
9108029-8	1997	This process seems to be essential for AP-1 activation by redox modification because co-overexpression of TRX and Ref-1 in COS-7 cells potentiated AP-1 activity only after TRX was transported into the nucleus by phorbol 12-myristate 13 acetate treatment.	Tetradecanoylphorbol Acetate	212-243	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	114-119
1344659-6	1992	GM-CSF mRNA was expressed by the A375 melanoma line only after induction with PMA.	Tetradecanoylphorbol Acetate	78-81	colony stimulating factor 2	Homo sapiens	0-6
9139854-7	1997	This is paralleled by the induction of several proteinase genes such as t-PA, urokinase, and pro-cathepsins B and L. Contrary to activated PKC, Fos in this system seems to be unable to initiate terminal squamous-cell differentiation, as assessed by the production of cornified envelopes.	Tetradecanoylphorbol Acetate	72-76	endogenous retrovirus group K member 18	Homo sapiens	47-57
1378017-6	1992	The binding of GMP-140 to primed T cells is not influenced by preactivation with phorbol 12-myristate 13-acetate, is almost completely abolished by pretreatment of T cells with neuraminidase or trypsin, and is also strongly inhibited by EDTA, the soluble sulfated glycans dextran sulfate, fucoidan, and heparin, but not by chondroitin sulfates.	Tetradecanoylphorbol Acetate	81-112	selectin P	Homo sapiens	15-22
9101090-4	1997	Treatment of HL-60 cells with retinoic acid/DMSO (granulocytic) or phorbol 12-myristate 13-acetate (monocytic) results in apoptosis and in down-regulation of APE expression at both the RNA and protein levels.	Tetradecanoylphorbol Acetate	67-98	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	158-161
1388136-4	1992	Immunoblots with isoenzyme-specific anti-PKC monoclonal antibodies demonstrated expression of immunoreactive PKC alpha, PKC beta and PKC gamma proteins that were translocated to the membrane upon TPA plus ionomycin stimulation.	Tetradecanoylphorbol Acetate	196-199	protein kinase C gamma	Homo sapiens	133-142
1323305-5	1992	Moreover, TPA can stimulate the expression of either a CRE- or an SRE-driven beta-galactosidase reporter gene in such embryos.	Tetradecanoylphorbol Acetate	10-13	galactosidase, beta 1	Mus musculus	77-95
9156339-7	1997	Further studies showed that inhibition of TPA-induced endothelial cell morphogenesis by oxLDL is correlated with suppression of the protein kinase C (PKC) and ETS1/AP1 activities.	Tetradecanoylphorbol Acetate	42-45	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	164-167
9156339-8	1997	The results indicated that the inhibition of endothelial cell morphogenesis by oxLDL is probably mediated through inhibition of the TPA-activated PKC pathway and its subsequent suppression of the ETS1/AP1 activity.	Tetradecanoylphorbol Acetate	132-135	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	201-204
1535685-1	1992	Rat 6 fibroblasts that overproduce protein kinase C beta 1 (R6-PKC3 cells) are hypersensitive to complete transformation by the T24 H-ras oncogene; yet T24 H-ras-transformed R6-PKC3 cells are killed when exposed to 12-O-tetradecanoylphorbol-13-acetate (TPA) (W.-L. W. Hsiao, G. M. Housey, M. D. Johnson, and I.	Tetradecanoylphorbol Acetate	253-256	HRas proto-oncogene, GTPase	Homo sapiens	156-161
9101367-3	1997	Collagenase-1 gene expression was rapidly induced several-fold above control both by a phorbol ester, 12-o-tetradecanoyl phorbol 13 acetate, and interleukin-1 beta (IL-1 beta) in HIG-82 synoviocytes.	Tetradecanoylphorbol Acetate	102-139	interstitial collagenase	Oryctolagus cuniculus	0-13
1535685-6	1992	Treatment of an R6-PKC3 subclone that harbors a T24 H-ras gene under the control of an inducible mouse metallothionein I promoter with ZnSO4 and TPA is extremely cytocidal.	Tetradecanoylphorbol Acetate	145-148	HRas proto-oncogene, GTPase	Homo sapiens	52-57
9101367-9	1997	Collagenase-1 mRNA levels in TPA-stimulated cells were reduced to baseline levels in the pCMV.C alpha but not in the mutated C-alpha-transfected cells.	Tetradecanoylphorbol Acetate	29-32	interstitial collagenase	Oryctolagus cuniculus	0-13
9147290-1	1997	GT1-7 cells respond to treatment with the phorbol ester, phorbol 12-myristate 13-acetate (PMA), with an inhibition of transcription of the proGnRH gene and decreases in GnRH mRNA levels.	Tetradecanoylphorbol Acetate	90-93	retinoic acid induced 1	Mus musculus	0-3
1320009-2	1992	In contrast to the transient induction of the Egr-1 gene by serum or phorbol 12-myristate 13-acetate, these phosphatase inhibitors stimulated a sustained induction of the Egr-1 gene.	Tetradecanoylphorbol Acetate	69-100	early growth response 1	Homo sapiens	46-51
1320009-9	1992	Simultaneous treatment of cells with TPA and okadaic acid synergistically induced Egr-1 gene expression, and H7 strongly inhibits this induction.	Tetradecanoylphorbol Acetate	37-40	early growth response 1	Homo sapiens	82-87
9247650-3	1997	We observed that LFA-1-expressing K562 cannot bind to intercellular adhesion molecule 1-coated surfaces when stimulated by phorbol 12-myristate 13-acetate (PMA), whereas the LFA-1-activating antibody KIM185 markedly enhanced adhesion.	Tetradecanoylphorbol Acetate	156-159	integrin subunit alpha L	Homo sapiens	17-22
9045713-4	1997	This TPA-mediated enhancement can initially be detected as an accelerated acquisition of DNA binding and transcriptional activity of HSF1 resulting in elevated Hsp70 protein concentrations.	Tetradecanoylphorbol Acetate	5-8	heat shock transcription factor 1	Homo sapiens	133-137
9045713-5	1997	In the presence of TPA, the attenuation of HSF1 DNA binding activity during continuous exposure to heat shock occurs more rapidly and in concert with the appearance of newly synthesized Hsp70, which supports earlier studies on the autoregulatory role of Hsp70 in deactivation of HSF1.	Tetradecanoylphorbol Acetate	19-22	heat shock transcription factor 1	Homo sapiens	43-47
1381849-8	1992	These correlations were also found for AT III except active PAI-1 and tPA-PAI-1 complexes, but the correlations with acute phase reactants were stronger for HC II than AT III.	Tetradecanoylphorbol Acetate	70-73	serpin family E member 1	Homo sapiens	74-79
9045713-5	1997	In the presence of TPA, the attenuation of HSF1 DNA binding activity during continuous exposure to heat shock occurs more rapidly and in concert with the appearance of newly synthesized Hsp70, which supports earlier studies on the autoregulatory role of Hsp70 in deactivation of HSF1.	Tetradecanoylphorbol Acetate	19-22	heat shock transcription factor 1	Homo sapiens	279-283
9045713-6	1997	During heat stress, a correlation between the hyperphosphorylation of HSF1 and its transcriptional activity was observed, in both the presence and the absence of TPA.	Tetradecanoylphorbol Acetate	162-165	heat shock transcription factor 1	Homo sapiens	70-74
9111583-4	1997	When stimulated with anti-CD3 mAb plus phorbol 12-myristate 13-acetate (PMA), CD25 expression was clearly restored in certain cases of ALL.	Tetradecanoylphorbol Acetate	39-70	interleukin 2 receptor subunit alpha	Homo sapiens	78-82
1315505-7	1992	IL-1-induced CSF-1 production was not suppressed by the protein kinase C (PKC) inhibitor, H7, under conditions in which 12-O-tetradecanoylphorbol-13-acetate-induced CSF-1 production was completely abolished.	Tetradecanoylphorbol Acetate	120-156	interleukin 1 alpha	Homo sapiens	0-4
1315505-7	1992	IL-1-induced CSF-1 production was not suppressed by the protein kinase C (PKC) inhibitor, H7, under conditions in which 12-O-tetradecanoylphorbol-13-acetate-induced CSF-1 production was completely abolished.	Tetradecanoylphorbol Acetate	120-156	colony stimulating factor 1	Homo sapiens	13-18
1315505-7	1992	IL-1-induced CSF-1 production was not suppressed by the protein kinase C (PKC) inhibitor, H7, under conditions in which 12-O-tetradecanoylphorbol-13-acetate-induced CSF-1 production was completely abolished.	Tetradecanoylphorbol Acetate	120-156	colony stimulating factor 1	Homo sapiens	165-170
1315776-10	1992	Third, the two amiloride derivatives 5-(N,N-hexamethylene) and 5-(N-ethyl-N-isopropyl)amiloride that specifically block the function of the Na+/H+ antiport also revert the protective effect of GM-CSF, IL-3, and TPA on MO7-E cells.	Tetradecanoylphorbol Acetate	211-214	colony stimulating factor 2	Homo sapiens	193-199
9111583-4	1997	When stimulated with anti-CD3 mAb plus phorbol 12-myristate 13-acetate (PMA), CD25 expression was clearly restored in certain cases of ALL.	Tetradecanoylphorbol Acetate	72-75	interleukin 2 receptor subunit alpha	Homo sapiens	78-82
9037095-6	1997	The intermediate role of protein kinase C (PKC) in this process was indicated by the ability of phorbol 12-myristate 13-acetate to induce time- and dose-dependent increases in PEt and diacylglycerol, but not inositol trisphosphate, and by reduction of GnRH-induced PEt accumulation in PKC-depleted cells.	Tetradecanoylphorbol Acetate	96-127	gonadotropin releasing hormone 1	Homo sapiens	252-256
1584230-7	1992	Furthermore, we found Egr-1 expression could be achieved by direct activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) circumventing the classical sIg activated phosphatidylinositol signal transduction pathway.	Tetradecanoylphorbol Acetate	107-138	early growth response 1	Mus musculus	22-27
1584230-7	1992	Furthermore, we found Egr-1 expression could be achieved by direct activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) circumventing the classical sIg activated phosphatidylinositol signal transduction pathway.	Tetradecanoylphorbol Acetate	140-143	early growth response 1	Mus musculus	22-27
9013627-11	1997	In summary, the strong induction of COX-2 expression by PPs, thapsigargin, and okadaic acid suggests a possible role for COX-2 in the growth regulatory activity of these non-TPA-type tumor promoters.	Tetradecanoylphorbol Acetate	174-177	prostaglandin-endoperoxide synthase 2	Mus musculus	36-41
9070223-4	1997	Moreover, hPTP-J gene expression was down-regulated after Jurkat cells were stimulated by either PMA or calcium ionophore.	Tetradecanoylphorbol Acetate	97-100	protein tyrosine phosphatase receptor type U	Homo sapiens	10-16
1603084-4	1992	Treatment of cells in serum-free medium containing 0.25% BSA (MEM + BSA) with the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) decreased IGF-I and increased bFGF mRNA levels in a time- and dose-dependent fashion.	Tetradecanoylphorbol Acetate	112-143	insulin-like growth factor 1	Rattus norvegicus	160-165
9081220-4	1997	We found that TPA, ATA, and IGF-1 increased the degree of phosphorylation of a 27-kDa protein in a dose- and time-dependent manner in CHX-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	14-17	immunoglobulin kappa variable 3-20	Homo sapiens	77-81
1313698-5	1992	The synergistic effect between PMA and dibutyryl cAMP was further verified by SDS-PAGE followed by immunoblotting using a monoclonal antibody against the PAI-2.	Tetradecanoylphorbol Acetate	31-34	serpin family B member 2	Homo sapiens	154-159
9157598-3	1997	Differentiation of MEG-01 cells induced by 100 nM 12-O-tetradecanoylphorbol-13-acetate revealed the considerable increases in mRNA expression of rap1B, rab3B, rab4, ram and ran whereas the levels of rap2B, rhoA and rac1 decreased.	Tetradecanoylphorbol Acetate	50-86	RAP1B, member of RAS oncogene family	Homo sapiens	145-150
1558843-2	1992	Phorbol myristate acetate (PMA), a known activator of protein kinase C, induces a three to four-fold increase in t-PA and PAI-1 release over a period of 24 h, whereas cell-associated t-PA and PAI-1 levels remain relatively stable.	Tetradecanoylphorbol Acetate	0-25	serpin family E member 1	Homo sapiens	122-127
1558843-2	1992	Phorbol myristate acetate (PMA), a known activator of protein kinase C, induces a three to four-fold increase in t-PA and PAI-1 release over a period of 24 h, whereas cell-associated t-PA and PAI-1 levels remain relatively stable.	Tetradecanoylphorbol Acetate	27-30	serpin family E member 1	Homo sapiens	122-127
8999940-0	1997	Activation of 12-O-tetradecanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinases.	Tetradecanoylphorbol Acetate	14-50	interleukin 5	Homo sapiens	122-135
1558843-2	1992	Phorbol myristate acetate (PMA), a known activator of protein kinase C, induces a three to four-fold increase in t-PA and PAI-1 release over a period of 24 h, whereas cell-associated t-PA and PAI-1 levels remain relatively stable.	Tetradecanoylphorbol Acetate	27-30	serpin family E member 1	Homo sapiens	192-197
1558852-9	1992	Using monoclonal antibodies to neutralize IL-2 and block IL-2 receptors we showed that 1,25(OH)2D3 enhanced the IL-2-independent component of the A23187- and TPA-induced mitogenesis.	Tetradecanoylphorbol Acetate	158-161	interleukin 2	Mus musculus	42-46
1558852-9	1992	Using monoclonal antibodies to neutralize IL-2 and block IL-2 receptors we showed that 1,25(OH)2D3 enhanced the IL-2-independent component of the A23187- and TPA-induced mitogenesis.	Tetradecanoylphorbol Acetate	158-161	interleukin 2	Mus musculus	57-61
1558852-9	1992	Using monoclonal antibodies to neutralize IL-2 and block IL-2 receptors we showed that 1,25(OH)2D3 enhanced the IL-2-independent component of the A23187- and TPA-induced mitogenesis.	Tetradecanoylphorbol Acetate	158-161	interleukin 2	Mus musculus	57-61
8999940-5	1997	We show that IL-5 activates TPA response element (TRE)-dependent transcription in transfection experiments.	Tetradecanoylphorbol Acetate	28-31	interleukin 5	Homo sapiens	13-17
8995416-6	1997	However, the interaction of TLN with LFA-1 on HL-60 cells was divalent cation-independent and phorbol 12-myristate 13-acetate stimulation-independent.	Tetradecanoylphorbol Acetate	94-125	intercellular adhesion molecule 5	Homo sapiens	28-31
1371947-1	1992	The preferential growth of CD3-CD2-CD11a/CD18- thymocytes was obtained by stimulation of CD2-CD3- thymic cells with low doses of PMA (0.5 ng/ml) and subsequent culture in the presence of recombinant interleukin-2 (100 U/ml).	Tetradecanoylphorbol Acetate	129-132	CD2 molecule	Homo sapiens	31-34
1371947-1	1992	The preferential growth of CD3-CD2-CD11a/CD18- thymocytes was obtained by stimulation of CD2-CD3- thymic cells with low doses of PMA (0.5 ng/ml) and subsequent culture in the presence of recombinant interleukin-2 (100 U/ml).	Tetradecanoylphorbol Acetate	129-132	CD2 molecule	Homo sapiens	89-92
8995416-6	1997	However, the interaction of TLN with LFA-1 on HL-60 cells was divalent cation-independent and phorbol 12-myristate 13-acetate stimulation-independent.	Tetradecanoylphorbol Acetate	94-125	integrin subunit alpha L	Homo sapiens	37-42
1313435-1	1992	Neutrophils stimulated with 4 beta-phorbol 12-myristate 13-acetate (PMA) release large quantities of superoxide (O2-) and exhibit phosphorylation of two proteins with molecular masses of 47(p47) and 49 kDa (p49).	Tetradecanoylphorbol Acetate	28-66	pleckstrin	Homo sapiens	190-193
1313435-1	1992	Neutrophils stimulated with 4 beta-phorbol 12-myristate 13-acetate (PMA) release large quantities of superoxide (O2-) and exhibit phosphorylation of two proteins with molecular masses of 47(p47) and 49 kDa (p49).	Tetradecanoylphorbol Acetate	68-71	pleckstrin	Homo sapiens	190-193
9038873-1	1997	The phorbol ester, phorbol 12-myristate 13-acetate (PMA), induces mucin secretion in the colonic tumor cell line T84 in a Ca(2+)-independent manner.	Tetradecanoylphorbol Acetate	19-50	LOC100508689	Homo sapiens	66-71
1554749-2	1992	While phorbol esters such as phorbol 12-myristate 13-acetate (PMA) are thought to induce the transcription of these genes by activating protein kinase C (PKC), the signal transduction pathway(s) mediating the effects of EGF and serum are still unclear.	Tetradecanoylphorbol Acetate	62-65	epidermal growth factor	Mus musculus	220-223
9038873-1	1997	The phorbol ester, phorbol 12-myristate 13-acetate (PMA), induces mucin secretion in the colonic tumor cell line T84 in a Ca(2+)-independent manner.	Tetradecanoylphorbol Acetate	52-55	LOC100508689	Homo sapiens	66-71
1312373-3	1992	Analysis of the subcellular fractionation of unstimulated cells by Western blotting of isopycnic sucrose density gradient fractions with anti-Rap1 peptide antibodies indicated that Rap1A colocalized with cytochrome b in the plasma membrane as well as in the specific granule membranes and that it was translocated, along with cytochrome b, to the plasma membrane when the cells were stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	399-424	RAP1A, member of RAS oncogene family	Homo sapiens	181-186
9218534-4	1997	In sharp contrast, in B cells treated with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), strong interactions between the X2 box and NF-X2 containing c-Fos were observed.	Tetradecanoylphorbol Acetate	61-97	nuclear transcription factor, X-box binding 1	Homo sapiens	148-153
1312373-3	1992	Analysis of the subcellular fractionation of unstimulated cells by Western blotting of isopycnic sucrose density gradient fractions with anti-Rap1 peptide antibodies indicated that Rap1A colocalized with cytochrome b in the plasma membrane as well as in the specific granule membranes and that it was translocated, along with cytochrome b, to the plasma membrane when the cells were stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	426-429	RAP1A, member of RAS oncogene family	Homo sapiens	181-186
9218534-4	1997	In sharp contrast, in B cells treated with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), strong interactions between the X2 box and NF-X2 containing c-Fos were observed.	Tetradecanoylphorbol Acetate	99-102	nuclear transcription factor, X-box binding 1	Homo sapiens	148-153
1322517-0	1992	Dual effects of endothelin-1 on neurite outgrowth induced by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	61-97	endothelin 1	Gallus gallus	16-28
8978709-3	1997	PKC agonists [phorbol 12-myristate 13-acetate (PMA), phorbol 12,13-dibutyrate, and mezerein] also decreased alpha 2A-AR mRNA levels in a time- and concentration-dependent fashion.	Tetradecanoylphorbol Acetate	14-45	adrenoceptor alpha 2A	Rattus norvegicus	108-119
1322517-2	1992	Treatment of ganglia explants with 100 pM ET-1 did not affect neuronal development, but when added together with 12-O-tetradecanoylphorbol-13-acetate (TPA) a synergistic stimulation of neurite outgrowth was observed.	Tetradecanoylphorbol Acetate	151-154	endothelin 1	Gallus gallus	42-46
1322517-3	1992	In contrast, 10 nM ET-1 inhibited TPA-induced neurite outgrowth.	Tetradecanoylphorbol Acetate	34-37	endothelin 1	Gallus gallus	19-23
8978709-3	1997	PKC agonists [phorbol 12-myristate 13-acetate (PMA), phorbol 12,13-dibutyrate, and mezerein] also decreased alpha 2A-AR mRNA levels in a time- and concentration-dependent fashion.	Tetradecanoylphorbol Acetate	47-50	adrenoceptor alpha 2A	Rattus norvegicus	108-119
1372331-4	1992	SP synergized with phorbol 12-myristate 13-acetate (PMA) in a dose-dependent manner to induce IL-2 production.	Tetradecanoylphorbol Acetate	19-50	interleukin 2	Mus musculus	94-98
8978751-5	1997	Subcellular fractionation studies also showed that the myristoylated alanine-rich C-kinase substrate (MARCKS), a major neuronal PKC substrate that has been implicated in the mechanism of neurotransmitter release, translocated from membranes to cytosol in response to an 8-min TPA treatment.	Tetradecanoylphorbol Acetate	276-279	myristoylated alanine rich protein kinase C substrate	Homo sapiens	102-108
1372331-4	1992	SP synergized with phorbol 12-myristate 13-acetate (PMA) in a dose-dependent manner to induce IL-2 production.	Tetradecanoylphorbol Acetate	52-55	interleukin 2	Mus musculus	94-98
8978751-7	1997	The ability of TPA to enhance NA release and to cause the translocation and phosphorylation of MARCKS was inhibited by the PKC inhibitor Ro 31-8220 (10 microM).	Tetradecanoylphorbol Acetate	15-18	myristoylated alanine rich protein kinase C substrate	Homo sapiens	95-101
1545825-4	1992	In this paper, we report that overexpression of GAP blocks the phorbol ester (tetradecanoyl phorbol acetate [TPA])-induced activation of p42 mitogen-activated protein kinase (p42mapk), c-fos expression, and DNA synthesis.	Tetradecanoylphorbol Acetate	109-112	FBJ osteosarcoma oncogene	Mus musculus	185-190
8972184-3	1997	Deletion of the Raf zinc finger and replacement with a homologous zinc finger from protein kinase C gamma (PKC gamma) (to give gamma/Raf) also abrogates EGF-induced activation but enables a vigorous phorbol myristate acetate (PMA)-induced activation.	Tetradecanoylphorbol Acetate	199-224	zinc fingers and homeoboxes 2	Homo sapiens	133-136
1373232-2	1992	Because granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) play critical roles in the production of neutrophils from marrow precursors, we assessed the ability of leukocytes from neonates and adults to produce GM-CSF, G-CSF, and, for comparison, macrophage colony-stimulating factor (M-CSF) after stimulation with concanavalin A +/- phorbol myristate acetate [blood mononuclear cells (MC) and T lymphocytes] or lipopolysaccharide (monocytes).	Tetradecanoylphorbol Acetate	390-415	colony stimulating factor 3	Homo sapiens	109-114
8972184-3	1997	Deletion of the Raf zinc finger and replacement with a homologous zinc finger from protein kinase C gamma (PKC gamma) (to give gamma/Raf) also abrogates EGF-induced activation but enables a vigorous phorbol myristate acetate (PMA)-induced activation.	Tetradecanoylphorbol Acetate	226-229	zinc fingers and homeoboxes 2	Homo sapiens	133-136
9633822-6	1997	In contrast to the results for antisense-FGF-2 transfectants, culture of antisense-FGF-1 transfectants in medium containing both FGF-2 and TPA caused a 2.6-fold reduction in transfectant doubling-time that was significantly greater than that caused by independent treatment with either FGF-2 or TPA.	Tetradecanoylphorbol Acetate	295-298	fibroblast growth factor 2	Rattus norvegicus	129-134
1311927-3	1992	In CMK cells N-sam/flg transcript level was enhanced by the culture with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	73-109	filaggrin	Homo sapiens	19-22
1311927-3	1992	In CMK cells N-sam/flg transcript level was enhanced by the culture with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	111-114	filaggrin	Homo sapiens	19-22
9633822-6	1997	In contrast to the results for antisense-FGF-2 transfectants, culture of antisense-FGF-1 transfectants in medium containing both FGF-2 and TPA caused a 2.6-fold reduction in transfectant doubling-time that was significantly greater than that caused by independent treatment with either FGF-2 or TPA.	Tetradecanoylphorbol Acetate	295-298	fibroblast growth factor 2	Rattus norvegicus	129-134
9443649-4	1997	However, when phorbol myristate acetate (PMA)-activated T lymphocytes, which express lymphocyte function-associated antigen-1 (LFA-1), were cocultured with tumor cells, attachment of S20 increased twofold (60 +/- 11.9%) but AS6 showed no change (32 +/- 11%).	Tetradecanoylphorbol Acetate	14-39	integrin subunit alpha L	Homo sapiens	85-125
1311563-13	1992	Phorbol myristate acetate (PMA) induced the expression of tissue-factor activity and decreased thrombomodulin activity at the endothelial-cell surface.	Tetradecanoylphorbol Acetate	0-25	coagulation factor III, tissue factor	Homo sapiens	58-71
1311563-13	1992	Phorbol myristate acetate (PMA) induced the expression of tissue-factor activity and decreased thrombomodulin activity at the endothelial-cell surface.	Tetradecanoylphorbol Acetate	27-30	coagulation factor III, tissue factor	Homo sapiens	58-71
9443649-4	1997	However, when phorbol myristate acetate (PMA)-activated T lymphocytes, which express lymphocyte function-associated antigen-1 (LFA-1), were cocultured with tumor cells, attachment of S20 increased twofold (60 +/- 11.9%) but AS6 showed no change (32 +/- 11%).	Tetradecanoylphorbol Acetate	14-39	integrin subunit alpha L	Homo sapiens	127-132
1540155-1	1992	Four tumor promoters, i.e. PB, TPA, NAF, and DDT, added singly to a calcium-deprived synthetic medium, elicited early and late mitogenic effects and concurrent surges of nuclear poly(ADP-ribose) polymerase (pADPRP) activity in primary neonatal rat hepatocytes mutagenized with an intra-uterine dose of DMN.	Tetradecanoylphorbol Acetate	31-34	poly (ADP-ribose) polymerase 1	Rattus norvegicus	178-205
9443649-4	1997	However, when phorbol myristate acetate (PMA)-activated T lymphocytes, which express lymphocyte function-associated antigen-1 (LFA-1), were cocultured with tumor cells, attachment of S20 increased twofold (60 +/- 11.9%) but AS6 showed no change (32 +/- 11%).	Tetradecanoylphorbol Acetate	41-44	integrin subunit alpha L	Homo sapiens	85-125
1539618-1	1992	Exposure of human polymorphonuclear neutrophils to phorbol 12-myristate 13-acetate (PMA) results in a 70-75% reduction in the specific binding of 125I-granulocyte-macrophage colony-stimulating factor (GM-CSF) to its receptors.	Tetradecanoylphorbol Acetate	51-82	colony stimulating factor 2	Homo sapiens	146-199
9443649-4	1997	However, when phorbol myristate acetate (PMA)-activated T lymphocytes, which express lymphocyte function-associated antigen-1 (LFA-1), were cocultured with tumor cells, attachment of S20 increased twofold (60 +/- 11.9%) but AS6 showed no change (32 +/- 11%).	Tetradecanoylphorbol Acetate	41-44	integrin subunit alpha L	Homo sapiens	127-132
1539618-1	1992	Exposure of human polymorphonuclear neutrophils to phorbol 12-myristate 13-acetate (PMA) results in a 70-75% reduction in the specific binding of 125I-granulocyte-macrophage colony-stimulating factor (GM-CSF) to its receptors.	Tetradecanoylphorbol Acetate	51-82	colony stimulating factor 2	Homo sapiens	201-207
8977243-7	1996	In the progenitor K562 cell line, cells ectopically expressing functional FLP1 differentiated normally to megakaryocytes after induction with tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	142-171	protein tyrosine phosphatase, non-receptor type 18	Mus musculus	74-78
1539618-1	1992	Exposure of human polymorphonuclear neutrophils to phorbol 12-myristate 13-acetate (PMA) results in a 70-75% reduction in the specific binding of 125I-granulocyte-macrophage colony-stimulating factor (GM-CSF) to its receptors.	Tetradecanoylphorbol Acetate	84-87	colony stimulating factor 2	Homo sapiens	146-199
1539618-1	1992	Exposure of human polymorphonuclear neutrophils to phorbol 12-myristate 13-acetate (PMA) results in a 70-75% reduction in the specific binding of 125I-granulocyte-macrophage colony-stimulating factor (GM-CSF) to its receptors.	Tetradecanoylphorbol Acetate	84-87	colony stimulating factor 2	Homo sapiens	201-207
8977243-7	1996	In the progenitor K562 cell line, cells ectopically expressing functional FLP1 differentiated normally to megakaryocytes after induction with tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	173-176	protein tyrosine phosphatase, non-receptor type 18	Mus musculus	74-78
8977243-8	1996	In contrast, when K562 transfectants expressing an inactive mutant FLP1 protein were treated with TPA, the characteristic cell spreading and substrate adhesion that accompany megakaryocytic differentiation did not occur.	Tetradecanoylphorbol Acetate	98-101	protein tyrosine phosphatase, non-receptor type 18	Mus musculus	67-71
8980110-9	1996	In Raji cells, PLCgamma2 mRNA is expressed at low levels with a half life greater than 4 h. After treatment with serum, TPA, retinoic acid, or with 5-azacytidine increased levels of PLCgamma2 mRNA were induced in B-cells.	Tetradecanoylphorbol Acetate	120-123	phospholipase C gamma 2	Homo sapiens	15-24
1739124-9	1992	In contrast, phorbol 12-myristate 13-acetate (PMA) was a less potent inducer of MCSF gene expression and iron-oxidized low-density lipoproteins (ox-LDL) did not increase consistently MCSF mRNA or the synthesis and secretion of immunoreactive protein.	Tetradecanoylphorbol Acetate	13-44	colony stimulating factor 1	Homo sapiens	80-84
1739124-9	1992	In contrast, phorbol 12-myristate 13-acetate (PMA) was a less potent inducer of MCSF gene expression and iron-oxidized low-density lipoproteins (ox-LDL) did not increase consistently MCSF mRNA or the synthesis and secretion of immunoreactive protein.	Tetradecanoylphorbol Acetate	46-49	colony stimulating factor 1	Homo sapiens	80-84
1734031-4	1992	Incubation of wounded monolayers with either purified bovine uPA or agents able to induce PA activity, such as phorbol myristate acetate (PMA), vanadate, or bFGF, resulted in enhanced migration of cells (28-50%).	Tetradecanoylphorbol Acetate	138-141	plasminogen activator, urokinase	Bos taurus	61-64
8980110-9	1996	In Raji cells, PLCgamma2 mRNA is expressed at low levels with a half life greater than 4 h. After treatment with serum, TPA, retinoic acid, or with 5-azacytidine increased levels of PLCgamma2 mRNA were induced in B-cells.	Tetradecanoylphorbol Acetate	120-123	phospholipase C gamma 2	Homo sapiens	182-191
8940368-4	1996	The effect of PTH was maximal at 1 h and decreased almost to control levels by 6 h. Phorbol myristate acetate (PMA), forskolin, and 8-bromo-cAMP increased PGHS-2 mRNA levels, whereas ionomycin had no effect.	Tetradecanoylphorbol Acetate	84-109	prostaglandin-endoperoxide synthase 2	Mus musculus	155-161
1371192-2	1992	It is demonstrated that the binding of IgG2a and IgG2b but not IgG1 and IgG3 augments the biosynthesis of C3 both in the presence and in the absence of the phorbol ester, phorbol myristate acetate in the case of both cell types.	Tetradecanoylphorbol Acetate	171-196	immunoglobulin heavy variable V1-9	Mus musculus	39-44
8940368-4	1996	The effect of PTH was maximal at 1 h and decreased almost to control levels by 6 h. Phorbol myristate acetate (PMA), forskolin, and 8-bromo-cAMP increased PGHS-2 mRNA levels, whereas ionomycin had no effect.	Tetradecanoylphorbol Acetate	111-114	prostaglandin-endoperoxide synthase 2	Mus musculus	155-161
8940368-6	1996	Pretreatment of cells with 0.1 microM PMA for 16 h blocked the induction of PGHS-2 mRNA levels by PMA, but did not alter the effects of PTH and forskolin.	Tetradecanoylphorbol Acetate	38-41	prostaglandin-endoperoxide synthase 2	Mus musculus	76-82
1730737-3	1992	Staurosporin treatment hardly affected the TNF-alpha-induced increase in mRNA for the p51 subunit of NF-kappa B but interfered with any phorbol ester (PMA)-induced increase in p51 mRNA.	Tetradecanoylphorbol Acetate	151-154	tumor protein p63	Homo sapiens	176-179
8977313-8	1996	However, activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) mimicked the effects of IFN-alpha2.	Tetradecanoylphorbol Acetate	49-80	interferon alpha 2	Homo sapiens	111-121
1731339-2	1992	We now find that this EpRE is composed of two adjacent 9-base-pair motifs related in sequence to the AP-1 binding site, a transcriptional enhancer originally identified as the phorbol 12-myristate 13-acetate (PMA) response element and known to be regulated by the binding of protein products of c-jun and c-fos genes.	Tetradecanoylphorbol Acetate	176-207	FBJ osteosarcoma oncogene	Mus musculus	305-310
1731339-2	1992	We now find that this EpRE is composed of two adjacent 9-base-pair motifs related in sequence to the AP-1 binding site, a transcriptional enhancer originally identified as the phorbol 12-myristate 13-acetate (PMA) response element and known to be regulated by the binding of protein products of c-jun and c-fos genes.	Tetradecanoylphorbol Acetate	209-212	FBJ osteosarcoma oncogene	Mus musculus	305-310
8977313-8	1996	However, activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) mimicked the effects of IFN-alpha2.	Tetradecanoylphorbol Acetate	82-85	interferon alpha 2	Homo sapiens	111-121
9022291-2	1996	The aim of the present study was to evaluate the influence of 12-O-tetradecanoylphorbol 13-acetate (TPA)--a potent ODC inducer on antiproliferative and apoptotic effects of TGF-beta 1 in L1210 leukemic cells.	Tetradecanoylphorbol Acetate	62-98	transforming growth factor, beta 1	Mus musculus	173-183
1733233-7	1992	Phorbol myristate acetate enhanced MRP-14 mRNA levels to a greater extent than MRP-8 mRNA levels, suggesting differential regulation of MRP gene expression by protein kinase C. The 1,25-(OH)2D3-induced relative increase in MRP mRNA levels was not changed by a 1,000-fold reduction in extracellular [Ca2+].	Tetradecanoylphorbol Acetate	0-25	MARCKS like 1	Homo sapiens	35-38
1312200-5	1992	Treatment of the C6 cells with phorbol 12-myristate 13-acetate caused a 13-fold increase in c-fos expression 0.5 h after administration and a decrease in proenkephalin mRNA.	Tetradecanoylphorbol Acetate	31-62	proenkephalin	Rattus norvegicus	154-167
9022291-2	1996	The aim of the present study was to evaluate the influence of 12-O-tetradecanoylphorbol 13-acetate (TPA)--a potent ODC inducer on antiproliferative and apoptotic effects of TGF-beta 1 in L1210 leukemic cells.	Tetradecanoylphorbol Acetate	100-103	transforming growth factor, beta 1	Mus musculus	173-183
1370255-7	1992	Incubation of CD20+ B cells with phorbol myristate acetate (PMA) for 72 hr increased the frequency of CD5 expressing B cells by more than threefold.	Tetradecanoylphorbol Acetate	33-58	CD5 molecule	Homo sapiens	102-105
9022291-10	1996	Administration of TPA simultaneously with TGF-beta 1 significantly reduced antiproliferative, apoptotic and necrotic effects of TGF-beta 1, and prevented its inhibitory action of ODC expression and activity.	Tetradecanoylphorbol Acetate	18-21	transforming growth factor, beta 1	Mus musculus	128-138
1370255-7	1992	Incubation of CD20+ B cells with phorbol myristate acetate (PMA) for 72 hr increased the frequency of CD5 expressing B cells by more than threefold.	Tetradecanoylphorbol Acetate	60-63	CD5 molecule	Homo sapiens	102-105
9022291-11	1996	It is concluded that: down-regulation of ODC expression may be one of the early events associated with TGF-beta 1-evoked suppression of growth and apoptosis; ODC is involved in the mechanism of protective action of TPA on TGF-beta 1-related growth inhibition of L1210 leukemic cells.	Tetradecanoylphorbol Acetate	215-218	transforming growth factor, beta 1	Mus musculus	103-113
9022291-11	1996	It is concluded that: down-regulation of ODC expression may be one of the early events associated with TGF-beta 1-evoked suppression of growth and apoptosis; ODC is involved in the mechanism of protective action of TPA on TGF-beta 1-related growth inhibition of L1210 leukemic cells.	Tetradecanoylphorbol Acetate	215-218	transforming growth factor, beta 1	Mus musculus	222-232
1727061-4	1992	The expression of both urokinase and the PAI-1-like molecule by U373 cells could be modulated by phorbol myristate acetate or by inflammatory mediators such as interferon-gamma and interleukin-1.	Tetradecanoylphorbol Acetate	97-122	serpin family E member 1	Homo sapiens	41-46
8973715-6	1996	Although addition of phorbol 12-myristate 13-acetate (TPA) had no effect on pHi in unstimulated conditions, the pHi recovery from an acid load was enhanced by exposure to TPA.	Tetradecanoylphorbol Acetate	171-174	glucose-6-phosphate isomerase	Homo sapiens	112-115
1389229-7	1992	By contrast, the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) prolonged survival of FDC-P1 cells on its own and potentiated the response to IFN-gamma or IL-4, although the combination of stimuli did not support long-term growth.	Tetradecanoylphorbol Acetate	44-75	interleukin 4	Mus musculus	173-177
1389229-7	1992	By contrast, the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) prolonged survival of FDC-P1 cells on its own and potentiated the response to IFN-gamma or IL-4, although the combination of stimuli did not support long-term growth.	Tetradecanoylphorbol Acetate	77-80	interleukin 4	Mus musculus	173-177
8969886-8	1996	PMA, on the other hand, induces equally well c-fos, c-jun and c-myc.	Tetradecanoylphorbol Acetate	0-3	jun proto-oncogene	Mus musculus	52-57
1517537-9	1992	The highest modulation of c-fos and c-myc was observed with TPA.	Tetradecanoylphorbol Acetate	60-63	FBJ osteosarcoma oncogene	Mus musculus	26-31
8948021-6	1996	Proper crosslinking of TCR together with CD4, CD8, or LFA-1 inhibits the death, and its inhibitory activity is mimicked by proper combinations of ionomycin, a calcium ionophore, and phorbol myristate acetate (PMA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	182-207	integrin subunit alpha L	Homo sapiens	54-59
1531644-3	1992	In contrast, in the presence of phorbol myristate acetate (PMA), the expression of IFN-gamma was decreased whereas the IL-4 message was dramatically enhanced.	Tetradecanoylphorbol Acetate	32-57	interleukin 4	Mus musculus	119-123
1531644-3	1992	In contrast, in the presence of phorbol myristate acetate (PMA), the expression of IFN-gamma was decreased whereas the IL-4 message was dramatically enhanced.	Tetradecanoylphorbol Acetate	59-62	interleukin 4	Mus musculus	119-123
8824244-7	1996	Among the protein knase C isoforms tested, protein kinase C beta, delta, and epsilon were most effective in promoting phosphorylation of Galpha12 and Galpha13 in a phorbol 12-myristate 13-acetate-dependent manner.	Tetradecanoylphorbol Acetate	164-195	protein kinase C beta	Homo sapiens	43-84
8892973-4	1996	Hydrocortisone also inhibited the basal secretion of uPA, as did interleukin-1beta and phorbol myristate acetate, both of which increase uPA levels in other cell systems.	Tetradecanoylphorbol Acetate	87-112	plasminogen activator, urokinase	Rattus norvegicus	137-140
1531763-2	1992	High in vitro growth ability was observed in response to recombinant human IL-2 (rIL-2) and human rIL-7, both in the absence of any co-mitogen and in combination with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	200-203	interleukin 2	Rattus norvegicus	81-86
8857945-5	1996	Moreover, in the human promyelocytic cell line HL-60, c-TRK expression was inducible by differentiation induction with tetradecanoyl-phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	153-156	neurotrophic receptor tyrosine kinase 1	Homo sapiens	56-59
1564939-4	1992	Changes in the levels of two phosphorylated forms of p19 were assessed in HL-60 promyelocytic cells and a variant HL-60 cell line which stopped growing and differentiated in response to TPA and were compared to changes seen in HL-60 variant lines which merely growth arrested when treated with TPA.	Tetradecanoylphorbol Acetate	294-297	interleukin 23 subunit alpha	Homo sapiens	53-56
1564939-5	1992	In lines which either did or did not differentiate, in response to TPA, the p19 protein was rapidly and transiently phosphorylated.	Tetradecanoylphorbol Acetate	67-70	interleukin 23 subunit alpha	Homo sapiens	76-79
1480044-1	1992	Human neutrophil collagenase (HNC) has been purified from extracts of fresh and outdated buffy coats and from the exudates of phorbol myristate acetate-stimulated neutrophils.	Tetradecanoylphorbol Acetate	126-151	matrix metallopeptidase 8	Homo sapiens	6-28
8863847-9	1996	When cells were pretreated with 12-O-tetradecanoyl-phorbol-13-acetate for 24 hr and subsequently challenged with ATP, Raf-1 activation and 42-kDa as well as 44-kDa MAPK tyrosine phosphorylation failed to be induced.	Tetradecanoylphorbol Acetate	32-69	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	118-123
1445622-5	1992	Whereas the AP-1 proteins junB, junD, and fosB did not show differential basal or TPA-inducible levels in P+ and P- cells, a 46-kDa species precipitated by anti-fra-1 antibody was TPA-inducible in P- cells but not in P+ cells, and c-jun protein was present at higher levels in TPA-treated and untreated P+ cells than in P- cells.	Tetradecanoylphorbol Acetate	180-183	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	161-166
1530879-0	1992	Altered expression of protein kinase C, lck, and CD45 in a 12-O-tetradecanoylphorbol-13-acetate-dependent leukemic T-cell variant that expresses a high level of interleukin-2 receptor.	Tetradecanoylphorbol Acetate	59-95	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	40-43
9121495-5	1996	TPA stimulation of the human GnRH gene is mediated by a consensus AP-1 site located at -402 to -396 bp, TGACTCA, which specifically binds c-fos and c-jun in Gn11 and NLT cells and recombinant c-jun in gel mobility shift studies.	Tetradecanoylphorbol Acetate	0-3	gonadotropin releasing hormone 1	Homo sapiens	29-33
1543537-3	1992	The nuclear proto-oncogenes c-fos and c-jun are referred to as early response genes because the classical tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces their expression to maximal levels within 2 h after treatment.	Tetradecanoylphorbol Acetate	121-157	FBJ osteosarcoma oncogene	Mus musculus	28-33
1543537-3	1992	The nuclear proto-oncogenes c-fos and c-jun are referred to as early response genes because the classical tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces their expression to maximal levels within 2 h after treatment.	Tetradecanoylphorbol Acetate	159-162	FBJ osteosarcoma oncogene	Mus musculus	28-33
1450490-4	1992	Thus, treatment of cells with TPA results in a reduction in the levels of c-myb and c-myc mRNA, while the expression of c-fos, c-jun, and junB is greatly enhanced.	Tetradecanoylphorbol Acetate	30-33	MYB proto-oncogene, transcription factor	Homo sapiens	74-79
1450490-4	1992	Thus, treatment of cells with TPA results in a reduction in the levels of c-myb and c-myc mRNA, while the expression of c-fos, c-jun, and junB is greatly enhanced.	Tetradecanoylphorbol Acetate	30-33	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	84-89
8804438-15	1996	PMA, an activator of PKC, dramatically decreased pH(i) but did not impair the spreading of neutrophils.	Tetradecanoylphorbol Acetate	0-3	glucose-6-phosphate isomerase	Homo sapiens	49-54
1279891-3	1992	Treatment with Bt2cAMP and TPA markedly increased the number of cells immunoreactive to VIP, PHM, neuropeptide Y, Met-enkephalin, substance P and tyrosine hydroxylase and also the contents of VIP and Met-enkephalin in the culture medium.	Tetradecanoylphorbol Acetate	27-30	neuropeptide Y	Homo sapiens	98-112
1748684-11	1991	Treatment of the cells with 12-O-tetradecanoylphorbol-13-acetate also increases pp80 but not pp96 phosphorylation, suggesting that erythropoietin triggers a protein kinase C-dependent pathway to pp80 and a protein kinase C-independent pathway to pp96.	Tetradecanoylphorbol Acetate	28-64	erythropoietin	Mus musculus	131-145
1743296-2	1991	Previous work has suggested that the activation of protein kinase C by TPA contributes to the decrease in c-myc expression during differentiation of these cells.	Tetradecanoylphorbol Acetate	71-74	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	106-111
1743296-3	1991	The present studies demonstrate that the decline in c-myc mRNA levels following exposure of HL-60 cells to TPA is preceded by an increase in expression of this gene.	Tetradecanoylphorbol Acetate	107-110	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	52-57
1744113-8	1991	The other can be activated by stimulation with TNF, interleukin-1, or lipopolysaccharide and in which a protein factor that can be induced by TPA treatment is involved.	Tetradecanoylphorbol Acetate	142-145	interleukin 1 alpha	Homo sapiens	52-65
1659532-4	1991	When cells were incubated with agents that elevate cAMP and TRH or phorbol 12-myristate 13-acetate, the decrease in TRH-R mRNA was greater than with either agent alone.	Tetradecanoylphorbol Acetate	67-98	thyrotropin releasing hormone receptor	Rattus norvegicus	116-121
1721021-5	1991	Prior activation with phorbol 12-myristate 13-acetate (PMA) significantly increased the ability of T cells to up-regulate endothelial ICAM-1 and also induced the expression of both ELAM-1 and VCAM-1.	Tetradecanoylphorbol Acetate	22-53	selectin E	Homo sapiens	181-187
1721021-5	1991	Prior activation with phorbol 12-myristate 13-acetate (PMA) significantly increased the ability of T cells to up-regulate endothelial ICAM-1 and also induced the expression of both ELAM-1 and VCAM-1.	Tetradecanoylphorbol Acetate	55-58	selectin E	Homo sapiens	181-187
1658006-3	1991	Exposure of a macrophage cell line (RAW264.7) to either fucoidan or phorbol myristate acetate (PMA) stimulates the secretion of uPA, whereas calcium ionophore or dibutyryl cyclic AMP had no effect.	Tetradecanoylphorbol Acetate	68-93	plasminogen activator, urokinase	Mus musculus	128-131
1658006-3	1991	Exposure of a macrophage cell line (RAW264.7) to either fucoidan or phorbol myristate acetate (PMA) stimulates the secretion of uPA, whereas calcium ionophore or dibutyryl cyclic AMP had no effect.	Tetradecanoylphorbol Acetate	95-98	plasminogen activator, urokinase	Mus musculus	128-131
1657961-4	1991	In the present study we show that protein kinase C activation by phorbol 12-myristate 13-acetate (PMA) induces PAF production in HUVEC by an increase of both alkyllyso-GP:acetyl-CoA acetyltransferase and DTT-insensitive alkylacetyl-G:CDP-choline choline-phosphotransferase.	Tetradecanoylphorbol Acetate	65-96	PCNA clamp associated factor	Homo sapiens	111-114
1657961-4	1991	In the present study we show that protein kinase C activation by phorbol 12-myristate 13-acetate (PMA) induces PAF production in HUVEC by an increase of both alkyllyso-GP:acetyl-CoA acetyltransferase and DTT-insensitive alkylacetyl-G:CDP-choline choline-phosphotransferase.	Tetradecanoylphorbol Acetate	98-101	PCNA clamp associated factor	Homo sapiens	111-114
1939160-3	1991	Activation of p21ras was not observed when the cells were stimulated with the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and pretreatment with TPA for 16 h, sufficient to down-regulate PKC activity, did not abolish p21ras activation by insulin.	Tetradecanoylphorbol Acetate	131-134	HRas proto-oncogene, GTPase	Homo sapiens	14-20
1939160-3	1991	Activation of p21ras was not observed when the cells were stimulated with the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and pretreatment with TPA for 16 h, sufficient to down-regulate PKC activity, did not abolish p21ras activation by insulin.	Tetradecanoylphorbol Acetate	131-134	H3 histone pseudogene 16	Homo sapiens	14-17
1939160-3	1991	Activation of p21ras was not observed when the cells were stimulated with the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and pretreatment with TPA for 16 h, sufficient to down-regulate PKC activity, did not abolish p21ras activation by insulin.	Tetradecanoylphorbol Acetate	158-161	HRas proto-oncogene, GTPase	Homo sapiens	14-20
1939160-3	1991	Activation of p21ras was not observed when the cells were stimulated with the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and pretreatment with TPA for 16 h, sufficient to down-regulate PKC activity, did not abolish p21ras activation by insulin.	Tetradecanoylphorbol Acetate	158-161	H3 histone pseudogene 16	Homo sapiens	14-17
1915667-3	1991	In this paper we show that epidermal growth factor (EGF)- and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced expression of the c-fos and c-jun protooncogenes is decreased in microgravity, while no effect of gravity changes was observed on A23187- and forskolin-induced expression of these genes.	Tetradecanoylphorbol Acetate	101-104	epidermal growth factor	Homo sapiens	27-50
1915667-3	1991	In this paper we show that epidermal growth factor (EGF)- and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced expression of the c-fos and c-jun protooncogenes is decreased in microgravity, while no effect of gravity changes was observed on A23187- and forskolin-induced expression of these genes.	Tetradecanoylphorbol Acetate	101-104	epidermal growth factor	Homo sapiens	52-55
1663075-6	1991	PMA priming, which has been reported to up-regulate scavenger receptor expression in THP-1 cells, significantly enhanced IL-1 production by fucoidan and poly I.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 alpha	Homo sapiens	121-125
1803346-7	1991	In EGF-treated cells, staurosporine and TPA, but not H-7, decreased DNA synthesis.	Tetradecanoylphorbol Acetate	40-43	epidermal growth factor	Mus musculus	3-6
1913657-0	1991	Prostratin, a nonpromoting phorbol ester, inhibits induction by phorbol 12-myristate 13-acetate of ornithine decarboxylase, edema, and hyperplasia in CD-1 mouse skin.	Tetradecanoylphorbol Acetate	64-95	CD1 antigen complex	Mus musculus	150-154
1913657-1	1991	Pretreatment of CD-1 mouse skin with prostratin (12-deoxyphorbol 13-acetate) inhibited biological response to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	110-141	CD1 antigen complex	Mus musculus	16-20
1680700-6	1991	When concanavalin A (Con A)-activated spleen cells were restimulated with Con A and phorbol 12-myristate 13-acetate (PMA), higher levels of IL2, IL4 and IL5 mRNA were induced, as detected both by increased frequencies of positive cells, and by more mRNA per cell.	Tetradecanoylphorbol Acetate	84-115	interleukin 2	Mus musculus	140-143
1680700-6	1991	When concanavalin A (Con A)-activated spleen cells were restimulated with Con A and phorbol 12-myristate 13-acetate (PMA), higher levels of IL2, IL4 and IL5 mRNA were induced, as detected both by increased frequencies of positive cells, and by more mRNA per cell.	Tetradecanoylphorbol Acetate	84-115	interleukin 4	Mus musculus	145-148
1680700-6	1991	When concanavalin A (Con A)-activated spleen cells were restimulated with Con A and phorbol 12-myristate 13-acetate (PMA), higher levels of IL2, IL4 and IL5 mRNA were induced, as detected both by increased frequencies of positive cells, and by more mRNA per cell.	Tetradecanoylphorbol Acetate	84-115	interleukin 5	Mus musculus	153-156
1680700-6	1991	When concanavalin A (Con A)-activated spleen cells were restimulated with Con A and phorbol 12-myristate 13-acetate (PMA), higher levels of IL2, IL4 and IL5 mRNA were induced, as detected both by increased frequencies of positive cells, and by more mRNA per cell.	Tetradecanoylphorbol Acetate	117-120	interleukin 2	Mus musculus	140-143
1680700-6	1991	When concanavalin A (Con A)-activated spleen cells were restimulated with Con A and phorbol 12-myristate 13-acetate (PMA), higher levels of IL2, IL4 and IL5 mRNA were induced, as detected both by increased frequencies of positive cells, and by more mRNA per cell.	Tetradecanoylphorbol Acetate	117-120	interleukin 5	Mus musculus	153-156
1939349-14	1991	In a manner identical to the serum-containing cultures (Wu and Byus (1984] the addition of TPA and exogenous ornithine to the serum-free cells caused a dose-dependent increase in intracellular putrescine (up to 5-fold) and a concomitant decrease in ODC activity in comparison to stimulation with TPA alone.	Tetradecanoylphorbol Acetate	91-94	ornithine decarboxylase 1	Rattus norvegicus	249-252
1660595-8	1991	Addition of 0.1-1 mumol/l phorbol 12-myristate 13-acetate (TPA) had little effect on pHi within 10 min; however, exposure to TPA for 120 min resulted in a significant rise in pHi.	Tetradecanoylphorbol Acetate	26-57	glucose-6-phosphate isomerase	Rattus norvegicus	175-178
1660595-8	1991	Addition of 0.1-1 mumol/l phorbol 12-myristate 13-acetate (TPA) had little effect on pHi within 10 min; however, exposure to TPA for 120 min resulted in a significant rise in pHi.	Tetradecanoylphorbol Acetate	59-62	glucose-6-phosphate isomerase	Rattus norvegicus	175-178
1660595-8	1991	Addition of 0.1-1 mumol/l phorbol 12-myristate 13-acetate (TPA) had little effect on pHi within 10 min; however, exposure to TPA for 120 min resulted in a significant rise in pHi.	Tetradecanoylphorbol Acetate	125-128	glucose-6-phosphate isomerase	Rattus norvegicus	85-88
1660595-8	1991	Addition of 0.1-1 mumol/l phorbol 12-myristate 13-acetate (TPA) had little effect on pHi within 10 min; however, exposure to TPA for 120 min resulted in a significant rise in pHi.	Tetradecanoylphorbol Acetate	125-128	glucose-6-phosphate isomerase	Rattus norvegicus	175-178
1833864-10	1991	The production of IL-2 by PMA-ionomycin stimulated T cells was not inhibited by discodermolide; however, the percentage of IL-2 receptor-bearing cells as measured by immunofluorescence with 7D4 antibody, specific for the 55-kDa chain (p55) comprising the murine IL-2 receptor, was reduced.	Tetradecanoylphorbol Acetate	26-29	interleukin 2	Mus musculus	18-22
1861152-4	1991	Further, an increase in calcium/phospholipid-dependent kinase (PKC) activity resulting from the treatment of PC12 cells with NGF and TPA was observed concomitant with the increased phosphorylation of NF-M.	Tetradecanoylphorbol Acetate	133-136	neurofilament medium chain	Rattus norvegicus	200-204
1861152-6	1991	Finally, when PC12 cells were rendered PKC-deficient by treatment with 1 muM TPA for 24 h, NGF maintained the ability to induce an increase in NF-M phosphorylation, though not to the level attained in cells which were not PKC-deficient.	Tetradecanoylphorbol Acetate	77-80	neurofilament medium chain	Rattus norvegicus	143-147
1861152-7	1991	These data suggest that NGF with or without TPA stimulates NF-M phosphorylation as a result of a complex series of events which include PKC-independent and PKC-dependent pathways.	Tetradecanoylphorbol Acetate	44-47	neurofilament medium chain	Rattus norvegicus	59-63
8781490-10	1996	In vitro, initiation of differentiation of the human megakaryoblastic cell line CHRF-288-11 with phorbol 12-myristate 13-acetate leads to a very strong upregulation of rDEP-1 transcripts.	Tetradecanoylphorbol Acetate	97-128	protein tyrosine phosphatase, receptor type, J	Rattus norvegicus	168-174
1916899-2	1991	BMCMC required activation by phorbol myristate acetate (PMA) to adhere to fibronectin, whereas MCP-5 displayed spontaneous adherence.	Tetradecanoylphorbol Acetate	56-59	fibronectin 1	Mus musculus	74-85
8836045-4	1996	Investigation into the intracellular mechanisms of PACAP action revealed that the increase in L-channel currents was blocked by calphostin C and bisindolylmaleimide IV [protein kinase C (PKC) inhibitors] and mimicked by 4 beta-phorbol 12-myristate 13-acetate (PMA), an activator of PKC.	Tetradecanoylphorbol Acetate	222-258	adenylate cyclase activating polypeptide 1	Rattus norvegicus	51-56
1713680-7	1991	Phorbol 12-myristate 13-acetate, a known activator of protein kinase C (PKC), weakly induces NF-kappa B-like activity, ELAM-1 mRNA, and ELAM-1 surface expression in HUVEC.	Tetradecanoylphorbol Acetate	0-31	selectin E	Homo sapiens	119-125
1713680-7	1991	Phorbol 12-myristate 13-acetate, a known activator of protein kinase C (PKC), weakly induces NF-kappa B-like activity, ELAM-1 mRNA, and ELAM-1 surface expression in HUVEC.	Tetradecanoylphorbol Acetate	0-31	selectin E	Homo sapiens	136-142
8947589-7	1996	The differentiation of HL-60 cells induced by all-trans retinoic acid, dimethyl sulfoxide or phorbol-12-myristate 13-acetate was also enhanced by ethacrynic acid with increasing NBT-reducing and lysozyme activities and the expression of CD11b or CD14 surface antigen.	Tetradecanoylphorbol Acetate	93-124	CD14 molecule	Homo sapiens	246-250
8795721-5	1996	Mo-CM and serum starvation increased the expression while TPA treatment down-regulated the expression of Fc epsilon RI-alpha chain.	Tetradecanoylphorbol Acetate	58-61	Fc epsilon receptor Ia	Homo sapiens	105-130
1650198-6	1991	The effect of TPA on PLC-PI seems quite specific since no internalization was induced by TPA on transmembrane phosphatidylcholine-preferring PLC expression.	Tetradecanoylphorbol Acetate	14-17	heparan sulfate proteoglycan 2	Homo sapiens	21-24
1650198-6	1991	The effect of TPA on PLC-PI seems quite specific since no internalization was induced by TPA on transmembrane phosphatidylcholine-preferring PLC expression.	Tetradecanoylphorbol Acetate	14-17	heparan sulfate proteoglycan 2	Homo sapiens	141-144
1650198-7	1991	These results show that TPA can translocate the membrane-bound PLC-PI, probably by PKC activation.	Tetradecanoylphorbol Acetate	24-27	heparan sulfate proteoglycan 2	Homo sapiens	63-66
8896174-0	1996	A novel monoclonal antibody mNI-58A against the alpha-chain of leukocyte function-associated antigen-1 (LFA-1) blocks the homotypic cell aggregation and actively regulates morphological changes in the phorbol myristate acetate (PMA)-activated human monocyte-like cell line, U937.	Tetradecanoylphorbol Acetate	201-226	integrin subunit alpha L	Homo sapiens	63-102
1677566-3	1991	Particularly, stimulation of the TPA response element by active c-erbB-2 was prominent.	Tetradecanoylphorbol Acetate	33-36	erb-b2 receptor tyrosine kinase 2	Mus musculus	64-72
8896174-0	1996	A novel monoclonal antibody mNI-58A against the alpha-chain of leukocyte function-associated antigen-1 (LFA-1) blocks the homotypic cell aggregation and actively regulates morphological changes in the phorbol myristate acetate (PMA)-activated human monocyte-like cell line, U937.	Tetradecanoylphorbol Acetate	201-226	integrin subunit alpha L	Homo sapiens	104-109
1677566-5	1991	Transactivation of the TPA response element was also observed in a cell line that stably expresses active c-erbB-2.	Tetradecanoylphorbol Acetate	23-26	erb-b2 receptor tyrosine kinase 2	Mus musculus	106-114
8896174-0	1996	A novel monoclonal antibody mNI-58A against the alpha-chain of leukocyte function-associated antigen-1 (LFA-1) blocks the homotypic cell aggregation and actively regulates morphological changes in the phorbol myristate acetate (PMA)-activated human monocyte-like cell line, U937.	Tetradecanoylphorbol Acetate	228-231	integrin subunit alpha L	Homo sapiens	63-102
1677566-6	1991	The active c-erbB-2-induced transactivation of the TPA response element was partially prevented either by down-regulation of protein kinase C or by the protein kinase C inhibitor H7.	Tetradecanoylphorbol Acetate	51-54	erb-b2 receptor tyrosine kinase 2	Mus musculus	11-19
8896174-0	1996	A novel monoclonal antibody mNI-58A against the alpha-chain of leukocyte function-associated antigen-1 (LFA-1) blocks the homotypic cell aggregation and actively regulates morphological changes in the phorbol myristate acetate (PMA)-activated human monocyte-like cell line, U937.	Tetradecanoylphorbol Acetate	228-231	integrin subunit alpha L	Homo sapiens	104-109
1650454-1	1991	Gene transcription rates and mRNA levels of plasminogen activator inhibitor type 2 (PAI-2) are markedly induced by the tumor promoting agent phorbol 12-myristate 13-acetate (PMA) in human HT1080 fibrosarcoma cells.	Tetradecanoylphorbol Acetate	141-172	serpin family B member 2	Homo sapiens	44-82
1650454-1	1991	Gene transcription rates and mRNA levels of plasminogen activator inhibitor type 2 (PAI-2) are markedly induced by the tumor promoting agent phorbol 12-myristate 13-acetate (PMA) in human HT1080 fibrosarcoma cells.	Tetradecanoylphorbol Acetate	141-172	serpin family B member 2	Homo sapiens	84-89
1650454-1	1991	Gene transcription rates and mRNA levels of plasminogen activator inhibitor type 2 (PAI-2) are markedly induced by the tumor promoting agent phorbol 12-myristate 13-acetate (PMA) in human HT1080 fibrosarcoma cells.	Tetradecanoylphorbol Acetate	174-177	serpin family B member 2	Homo sapiens	44-82
8806458-2	1996	Fifty percent of the cofilin in the resting state was phosphorylated and dephosphorylation occurred after activation by fMLP or TPA.	Tetradecanoylphorbol Acetate	128-131	cofilin 1	Homo sapiens	21-28
1650454-1	1991	Gene transcription rates and mRNA levels of plasminogen activator inhibitor type 2 (PAI-2) are markedly induced by the tumor promoting agent phorbol 12-myristate 13-acetate (PMA) in human HT1080 fibrosarcoma cells.	Tetradecanoylphorbol Acetate	174-177	serpin family B member 2	Homo sapiens	84-89
8806458-9	1996	Reactivation of these cells with TPA resulted in the dephosphorylation of cofilin; fMLP activation did not lead to dephosphorylation.	Tetradecanoylphorbol Acetate	33-36	cofilin 1	Homo sapiens	74-81
2061327-2	1991	Previously, valyl-tRNA synthetase and the alpha, beta, and delta subunits of EF-1 were shown to be phosphorylated in reticulocytes in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	146-177	valine--tRNA ligase	Oryctolagus cuniculus	12-33
8806458-11	1996	Thus, we conclude that the dephosphorylation of cofilin is differently regulated depending on either fMLP or TPA activation.	Tetradecanoylphorbol Acetate	109-112	cofilin 1	Homo sapiens	48-55
2061327-2	1991	Previously, valyl-tRNA synthetase and the alpha, beta, and delta subunits of EF-1 were shown to be phosphorylated in reticulocytes in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	179-182	valine--tRNA ligase	Oryctolagus cuniculus	12-33
8702563-1	1996	Treatment of mesangial cells with either phorbol 12-myristate 13-acetate (PMA) or interleukin-1beta induces an increase in laminin B2 chain mRNA levels.	Tetradecanoylphorbol Acetate	41-72	laminin subunit gamma 1	Homo sapiens	123-139
8702563-1	1996	Treatment of mesangial cells with either phorbol 12-myristate 13-acetate (PMA) or interleukin-1beta induces an increase in laminin B2 chain mRNA levels.	Tetradecanoylphorbol Acetate	74-77	laminin subunit gamma 1	Homo sapiens	123-139
8702564-2	1996	125I-Heregulin binding to NIH 3T3 cells overexpressing the ErbB-4 receptor is rapidly decreased by 12-O-tetradecanoylphorbol-13-acetate (TPA) pretreatment.	Tetradecanoylphorbol Acetate	99-135	neuregulin 1	Mus musculus	5-14
2044931-7	1991	Phorbol myristate acetate was found to be a strong inducer of Leu-8 messenger RNA in Leu-8-positive lymphocytes; however, phorbol myristate acetate did not induce membrane Leu-8 expression or Leu-8 messenger RNA in lamina propria lymphocytes.	Tetradecanoylphorbol Acetate	0-25	selectin L	Homo sapiens	62-67
2044931-7	1991	Phorbol myristate acetate was found to be a strong inducer of Leu-8 messenger RNA in Leu-8-positive lymphocytes; however, phorbol myristate acetate did not induce membrane Leu-8 expression or Leu-8 messenger RNA in lamina propria lymphocytes.	Tetradecanoylphorbol Acetate	0-25	selectin L	Homo sapiens	85-90
8702564-2	1996	125I-Heregulin binding to NIH 3T3 cells overexpressing the ErbB-4 receptor is rapidly decreased by 12-O-tetradecanoylphorbol-13-acetate (TPA) pretreatment.	Tetradecanoylphorbol Acetate	137-140	neuregulin 1	Mus musculus	5-14
2044931-7	1991	Phorbol myristate acetate was found to be a strong inducer of Leu-8 messenger RNA in Leu-8-positive lymphocytes; however, phorbol myristate acetate did not induce membrane Leu-8 expression or Leu-8 messenger RNA in lamina propria lymphocytes.	Tetradecanoylphorbol Acetate	0-25	selectin L	Homo sapiens	85-90
8906362-7	1996	Using a chloramphenicol-acetyl transferase (CAT) assay, we identified a TPA sensitive domain within the promoter of the COL1A2 gene.	Tetradecanoylphorbol Acetate	72-75	collagen, type I, alpha 2	Mus musculus	120-126
2044931-7	1991	Phorbol myristate acetate was found to be a strong inducer of Leu-8 messenger RNA in Leu-8-positive lymphocytes; however, phorbol myristate acetate did not induce membrane Leu-8 expression or Leu-8 messenger RNA in lamina propria lymphocytes.	Tetradecanoylphorbol Acetate	0-25	selectin L	Homo sapiens	85-90
1830593-1	1991	Human granulocyte-macrophage colony-stimulating factor (GM-CSF) (0.1 nM) down-modulates its receptor in IL-3/GM-CSF dependent M-07e cells, in KG-1 cells and normal granulocytes, whereas phorbol esters 12-O-tetradecanoylphorbol-13-acetate (TPA) (2 nM) down-modulates the GM-CSF receptor in M-07e cells and granulocytes but not in KG-1 cells.	Tetradecanoylphorbol Acetate	201-237	colony stimulating factor 2	Homo sapiens	6-54
1830593-1	1991	Human granulocyte-macrophage colony-stimulating factor (GM-CSF) (0.1 nM) down-modulates its receptor in IL-3/GM-CSF dependent M-07e cells, in KG-1 cells and normal granulocytes, whereas phorbol esters 12-O-tetradecanoylphorbol-13-acetate (TPA) (2 nM) down-modulates the GM-CSF receptor in M-07e cells and granulocytes but not in KG-1 cells.	Tetradecanoylphorbol Acetate	201-237	colony stimulating factor 2	Homo sapiens	56-62
8871052-6	1996	In three out of nine clones tested, the stimulation with anti-CD2/CD28/phorbol myristate acetate (PMA) induced a shift of the IFN-gamma/IL-4 ratio towards a Th2-type cytokine profile.	Tetradecanoylphorbol Acetate	71-96	CD28 molecule	Homo sapiens	66-70
1830593-1	1991	Human granulocyte-macrophage colony-stimulating factor (GM-CSF) (0.1 nM) down-modulates its receptor in IL-3/GM-CSF dependent M-07e cells, in KG-1 cells and normal granulocytes, whereas phorbol esters 12-O-tetradecanoylphorbol-13-acetate (TPA) (2 nM) down-modulates the GM-CSF receptor in M-07e cells and granulocytes but not in KG-1 cells.	Tetradecanoylphorbol Acetate	239-242	colony stimulating factor 2	Homo sapiens	6-54
1830593-1	1991	Human granulocyte-macrophage colony-stimulating factor (GM-CSF) (0.1 nM) down-modulates its receptor in IL-3/GM-CSF dependent M-07e cells, in KG-1 cells and normal granulocytes, whereas phorbol esters 12-O-tetradecanoylphorbol-13-acetate (TPA) (2 nM) down-modulates the GM-CSF receptor in M-07e cells and granulocytes but not in KG-1 cells.	Tetradecanoylphorbol Acetate	239-242	colony stimulating factor 2	Homo sapiens	56-62
8871052-6	1996	In three out of nine clones tested, the stimulation with anti-CD2/CD28/phorbol myristate acetate (PMA) induced a shift of the IFN-gamma/IL-4 ratio towards a Th2-type cytokine profile.	Tetradecanoylphorbol Acetate	98-101	CD28 molecule	Homo sapiens	66-70
8663346-8	1996	DEX and PMA also decrease GH-induced tyrosyl phosphorylation of GHR and JAK2 with a magnitude and time course correlating with that of inhibition of GH binding.	Tetradecanoylphorbol Acetate	8-11	growth hormone receptor	Cricetulus griseus	64-67
1830593-5	1991	Moreover, unlike TPA, GM-CSF was still able to down-modulate its receptor in cells where PKC was inhibited by 1-(5-isoquinolonesulphonyl)-2-methylpiperazine (H7) and staurosporine or in cells where PKC was exhausted by prolonged incubation with 1 microM TPA.	Tetradecanoylphorbol Acetate	254-257	colony stimulating factor 2	Homo sapiens	22-28
8706726-5	1996	Induction of MT-MMP-1 by phorbol 12-myristate 13-acetate (PMA) required protein synthesis as shown by cycloheximide inhibition.	Tetradecanoylphorbol Acetate	25-56	matrix metallopeptidase 14	Homo sapiens	13-21
8706726-5	1996	Induction of MT-MMP-1 by phorbol 12-myristate 13-acetate (PMA) required protein synthesis as shown by cycloheximide inhibition.	Tetradecanoylphorbol Acetate	58-61	matrix metallopeptidase 14	Homo sapiens	13-21
1920533-1	1991	The phorbol ester 12-O-tetradecanoyl-acetate (TPA) induced prominent and transient changes in the organization of the cytoskeleton in cultured amoeboid microglial cells including redistribution of actin toward the center of the cells and in the subplasmalemmal region, appearance of fine actin filaments, retraction of microtubules (MT), and rearrangement of intermediate filaments (IF) containing vimentin.	Tetradecanoylphorbol Acetate	46-49	vimentin	Homo sapiens	398-406
1920533-6	1991	Using this antibody, rearrangement of IF involving vimentin phosphorylation was detected within 15 to 60 min of treatment with 50 nM TPA and consisted in the appearance of intense perinuclear fluorescent label.	Tetradecanoylphorbol Acetate	133-136	vimentin	Homo sapiens	51-59
1920533-8	1991	Immunochemical analysis of nonionic detergent-soluble and -insoluble extracts from untreated and TPA-treated cells revealed no differences in vimentin solubility suggesting that TPA induced vimentin phosphorylation does not result in notable vimentin filament disassembly.	Tetradecanoylphorbol Acetate	97-100	vimentin	Homo sapiens	190-198
1920533-8	1991	Immunochemical analysis of nonionic detergent-soluble and -insoluble extracts from untreated and TPA-treated cells revealed no differences in vimentin solubility suggesting that TPA induced vimentin phosphorylation does not result in notable vimentin filament disassembly.	Tetradecanoylphorbol Acetate	97-100	vimentin	Homo sapiens	190-198
1920533-8	1991	Immunochemical analysis of nonionic detergent-soluble and -insoluble extracts from untreated and TPA-treated cells revealed no differences in vimentin solubility suggesting that TPA induced vimentin phosphorylation does not result in notable vimentin filament disassembly.	Tetradecanoylphorbol Acetate	178-181	vimentin	Homo sapiens	190-198
8660925-1	1996	The subcellular localization of protein kinase C (PKC)-delta was determined in HL60 cells differentiated toward monocytes/macrophages by treatment with TPA.	Tetradecanoylphorbol Acetate	152-155	protein kinase C delta	Homo sapiens	32-60
1920533-8	1991	Immunochemical analysis of nonionic detergent-soluble and -insoluble extracts from untreated and TPA-treated cells revealed no differences in vimentin solubility suggesting that TPA induced vimentin phosphorylation does not result in notable vimentin filament disassembly.	Tetradecanoylphorbol Acetate	178-181	vimentin	Homo sapiens	190-198
1920533-9	1991	However the extent of vimentin degradation was more prominent in TPA-treated cultures indicating a higher sensitivity of vimentin to proteolytic degradation.	Tetradecanoylphorbol Acetate	65-68	vimentin	Homo sapiens	22-30
8662934-0	1996	The human histidine decarboxylase promoter is regulated by gastrin and phorbol 12-myristate 13-acetate through a downstream cis-acting element.	Tetradecanoylphorbol Acetate	71-102	histidine decarboxylase	Homo sapiens	10-33
1920533-9	1991	However the extent of vimentin degradation was more prominent in TPA-treated cultures indicating a higher sensitivity of vimentin to proteolytic degradation.	Tetradecanoylphorbol Acetate	65-68	vimentin	Homo sapiens	121-129
8662934-1	1996	Transcriptional regulation of the human histidine decarboxylase (HDC) gene by gastrin and the phorbol ester phorbol 12-myristate 13-acetate (PMA) was studied using transient transfection of human HDC promoter-luciferase constructs in a human gastric carcinoma cell line (AGS-B) that expresses the human cholecystokinin-B/gastrin receptor.	Tetradecanoylphorbol Acetate	108-139	histidine decarboxylase	Homo sapiens	40-63
8662934-1	1996	Transcriptional regulation of the human histidine decarboxylase (HDC) gene by gastrin and the phorbol ester phorbol 12-myristate 13-acetate (PMA) was studied using transient transfection of human HDC promoter-luciferase constructs in a human gastric carcinoma cell line (AGS-B) that expresses the human cholecystokinin-B/gastrin receptor.	Tetradecanoylphorbol Acetate	108-139	histidine decarboxylase	Homo sapiens	65-68
2050694-4	1991	The valyl-tRNA synthetase.EF-1 complex has been purified by gel filtration and tRNA-Sepharose chromatography from 32P-labeled rabbit reticulocytes stimulated by phorbol 12-myristate 13-acetate (PMA) and compared to the complex purified from control cells.	Tetradecanoylphorbol Acetate	161-192	valine--tRNA ligase	Oryctolagus cuniculus	4-25
8662746-4	1996	Tyrosine phosphorylation of Raf-1 is induced by FcgammaRI activation and not by PMA (1 microg/ml), N-formyl-Met-Leu-Phe (1 microM), calcium ionophore (1 microM), thrombin (0.05 unit/ml), FcgammaRII, or FcgammaRIII stimulation.	Tetradecanoylphorbol Acetate	80-83	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	28-33
2050694-4	1991	The valyl-tRNA synthetase.EF-1 complex has been purified by gel filtration and tRNA-Sepharose chromatography from 32P-labeled rabbit reticulocytes stimulated by phorbol 12-myristate 13-acetate (PMA) and compared to the complex purified from control cells.	Tetradecanoylphorbol Acetate	194-197	valine--tRNA ligase	Oryctolagus cuniculus	4-25
8649769-2	1996	Okadaic acid increased AP-1 binding to a consensus TPA responsive element (TRE) within 2 h; maximum stimulation was observed at 6 h followed by a gradual decrease to basal levels within 24 h. Jun B, Jun D and Fos B proteins were identified as the major components of the AP-1 complex binding to the TRE element at 6 h. Inhibition of transcription with actinomycin D and inhibition of protein synthesis with cycloheximide abrogated the okadaic acid effect on AP-1 DNA binding, indicating that transcription and translation are required for okadaic acid increased TRE binding activity.	Tetradecanoylphorbol Acetate	51-54	jun proto-oncogene	Mus musculus	23-27
1904062-1	1991	The phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate [TPA) or phorbol 12-myristate 13-acetate), directly activates the calcium- and phospholipid-dependent protein kinase C (protein kinase C), which, in turn, generates a number of cellular responses.	Tetradecanoylphorbol Acetate	34-70	plasminogen activator, tissue type	Rattus norvegicus	72-75
8805854-5	1996	Phorbol myristate acetate (PMA) induced macrophage-like differentiation and up-regulated the gamma c chain mRNA expression in THP-1 cells.	Tetradecanoylphorbol Acetate	0-25	interleukin 2 receptor subunit gamma	Homo sapiens	93-100
8649402-6	1996	PAC-1 transcription induced by phorbol myristate acetate stimulation and the expression of the v-ras or v-raf oncogene is mediated via the E-box motif and an AP-2-related site and coincides with increased binding activity of the constitutive 53-kDa E-box-binding protein and induced binding of AP-2.	Tetradecanoylphorbol Acetate	31-56	transcription factor AP-2, alpha	Mus musculus	158-162
2052598-7	1991	Similarly, lysates made from eggs treated with phorbol 12-myristate 13-acetate support sperm chromatin decondensation in vitro and yet retain high MPF activity, measured either as the ability to induce meiotic resumption in oocytes or as histone H1 kinase activity.	Tetradecanoylphorbol Acetate	47-78	cyclin-dependent kinase 1 S homeolog	Xenopus laevis	147-150
2052609-2	1991	When Jurkat cells or their Nef-2-expressing transformants are treated with phorbol 12-myristate 13-acetate (PMA) plus either phytohemagglutinin (PHA) or antibodies against CD3 epsilon, T-cell receptor beta chain, or CD2, there is a prompt increase in interleukin 2 (IL-2) mRNA and intracellular calcium and in the IL-2 receptor alpha chain on the cell surface.	Tetradecanoylphorbol Acetate	75-106	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	172-211
8649402-6	1996	PAC-1 transcription induced by phorbol myristate acetate stimulation and the expression of the v-ras or v-raf oncogene is mediated via the E-box motif and an AP-2-related site and coincides with increased binding activity of the constitutive 53-kDa E-box-binding protein and induced binding of AP-2.	Tetradecanoylphorbol Acetate	31-56	transcription factor AP-2, alpha	Mus musculus	294-298
8649405-6	1996	In vivo genomic footprinting revealed that Sp1 contacts the CD11c promoter within the regions -69 to -63 and -116 to -105 in phorbol 12-myristate 13-acetate-differentiated HL60 cells but not in undifferentiated HL60 cells or in Molt4 or HeLa cells.	Tetradecanoylphorbol Acetate	125-156	integrin subunit alpha X	Homo sapiens	60-65
8647875-2	1996	We have found that human fascin is phosphorylated in vivo upon treatment with 12-O-tetradecanoylphorbol-13-acetate, a tumor promoter.	Tetradecanoylphorbol Acetate	78-114	fascin actin-bundling protein 1	Homo sapiens	25-31
1710933-6	1991	Brief exposure of EC to PMA strongly inhibits thrombin-induced [Ca2+]i rise, acetyltransferase activation and PAF production, suggesting that, in addition to the positive forward action, PKC provides a negative feedback control over membrane signalling pathways involved in the thrombin effect on EC.	Tetradecanoylphorbol Acetate	24-27	PCNA clamp associated factor	Homo sapiens	110-113
1711295-4	1991	Attachment of phorbol 12-myristate, 13-acetate (PMA)-stimulated W256 cells to endothelial monolayers was increased 1.8 +/- 0.1-fold and damage (3H-2-deoxyglucose release from labeled endothelium) 1.4 +/- 0.1-fold after 4-hour pretreatment of the endothelium with 10 ng/ml recombinant human interleukin-1 alpha (rIL-1 alpha).	Tetradecanoylphorbol Acetate	48-51	interleukin 1 alpha	Homo sapiens	290-309
8647875-8	1996	These results suggest that phosphorylation of fascin plays a role in actin reorganization after treatment with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	111-147	fascin actin-bundling protein 1	Homo sapiens	46-52
1673981-11	1991	Stimulation of T cells with ionomycin and PMA greatly increased the expression of CD2 and CD44 without increasing the number of molecules associated with the cytoskeleton.	Tetradecanoylphorbol Acetate	42-45	CD2 molecule	Homo sapiens	82-85
8625537-9	1996	Similar but transient inhibition of most T-cell products (IL-2, IL-3, IL-4, IL-5, IL-10, TNF-beta and GM-CSF) was noted in the PMA/ionomycin-containing cultures.	Tetradecanoylphorbol Acetate	127-130	interleukin 5	Homo sapiens	76-80
8621804-1	1996	Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed.	Tetradecanoylphorbol Acetate	172-175	integrin subunit alpha L	Homo sapiens	79-118
1828153-7	1991	Ang II (10(9) - 10(-8) M) and a protein kinase C activator, phorbol 12-myristate 13-acetate (PMA, 10(-8) M) rapidly induced c-fos as well as c-Jun and Jun-B mRNA expression in RASM cells.	Tetradecanoylphorbol Acetate	60-91	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	151-156
1828153-7	1991	Ang II (10(9) - 10(-8) M) and a protein kinase C activator, phorbol 12-myristate 13-acetate (PMA, 10(-8) M) rapidly induced c-fos as well as c-Jun and Jun-B mRNA expression in RASM cells.	Tetradecanoylphorbol Acetate	93-96	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	151-156
8621804-1	1996	Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed.	Tetradecanoylphorbol Acetate	172-175	integrin subunit alpha L	Homo sapiens	120-125
8621804-1	1996	Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed.	Tetradecanoylphorbol Acetate	177-208	integrin subunit alpha L	Homo sapiens	79-118
1673843-7	1991	Low responses to anti-CD2 were corrected to normal by the coaddition of a submitogenic amount of phorbol myristate acetate (1 ng/ml).	Tetradecanoylphorbol Acetate	97-122	CD2 molecule	Homo sapiens	22-25
8621804-1	1996	Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed.	Tetradecanoylphorbol Acetate	177-208	integrin subunit alpha L	Homo sapiens	120-125
8780027-6	1996	Stimulation of oligodendrocyte progenitors with the growth factors PDGF and basic fibroblast growth factor and a protein kinase C-activating tumor promoter, phorbol 12-myristate 13-acetate, resulted in a rapid activation of p42mapk (ERK2) and, to a lesser extent, p44mapk (ERK1).	Tetradecanoylphorbol Acetate	157-188	mitogen activated protein kinase 1	Rattus norvegicus	224-231
2040659-2	1991	We investigated ODC mRNA accumulation in cells treated with either insulin or 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	78-115	ornithine decarboxylase 1	Rattus norvegicus	16-19
2040659-2	1991	We investigated ODC mRNA accumulation in cells treated with either insulin or 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	117-120	ornithine decarboxylase 1	Rattus norvegicus	16-19
8780027-6	1996	Stimulation of oligodendrocyte progenitors with the growth factors PDGF and basic fibroblast growth factor and a protein kinase C-activating tumor promoter, phorbol 12-myristate 13-acetate, resulted in a rapid activation of p42mapk (ERK2) and, to a lesser extent, p44mapk (ERK1).	Tetradecanoylphorbol Acetate	157-188	mitogen activated protein kinase 1	Rattus norvegicus	233-237
2040659-3	1991	Both agents caused rapid accumulation of ODC mRNA: for TPA, it was maximal 3 hr after treatment (4-6-fold greater than control cells) and returned quickly to control levels; for insulin, it was significantly longer, continuing to increase for at least 6 hr.	Tetradecanoylphorbol Acetate	55-58	ornithine decarboxylase 1	Rattus norvegicus	41-44
8780027-6	1996	Stimulation of oligodendrocyte progenitors with the growth factors PDGF and basic fibroblast growth factor and a protein kinase C-activating tumor promoter, phorbol 12-myristate 13-acetate, resulted in a rapid activation of p42mapk (ERK2) and, to a lesser extent, p44mapk (ERK1).	Tetradecanoylphorbol Acetate	157-188	mitogen activated protein kinase 3	Rattus norvegicus	264-271
2040659-4	1991	Simultaneous treatment with TPA and insulin led to additive effects on ODC mRNA.	Tetradecanoylphorbol Acetate	28-31	ornithine decarboxylase 1	Rattus norvegicus	71-74
2040659-5	1991	Induction of ODC by TPA was blocked by down-regulation or inhibition of protein kinase C (PKC), consistent with a PKC-mediated mechanism.	Tetradecanoylphorbol Acetate	20-23	ornithine decarboxylase 1	Rattus norvegicus	13-16
8780027-6	1996	Stimulation of oligodendrocyte progenitors with the growth factors PDGF and basic fibroblast growth factor and a protein kinase C-activating tumor promoter, phorbol 12-myristate 13-acetate, resulted in a rapid activation of p42mapk (ERK2) and, to a lesser extent, p44mapk (ERK1).	Tetradecanoylphorbol Acetate	157-188	mitogen activated protein kinase 3	Rattus norvegicus	273-277
2040659-9	1991	These results suggest that although insulin and TPA share some common cytoplasmic signalling pathways, their effects on phosphorylation of nuclear proteins and transcription of ODC may be mediated by distinct factors.	Tetradecanoylphorbol Acetate	48-51	ornithine decarboxylase 1	Rattus norvegicus	177-180
8629998-2	1996	We report that MIII (but not OLT) is a nontoxic inhibitor of long terminal repeat (LTR)-driven expression of beta-galactosidase in phorbol-12-myristate-13-acetate (PMA)-stimulated and unstimulated 293.27.2 cells (ED50 = 14 +/- 1 and 41 +/- 4 microM, respectively).	Tetradecanoylphorbol Acetate	131-162	galactosidase beta 1	Homo sapiens	109-127
1707932-5	1991	Moreover, the PKC inhibitor staurosporine can block PMA-induced endothelial leukocyte adhesion molecule 1 expression at 4 h, but does not inhibit the actions of TNF.	Tetradecanoylphorbol Acetate	52-55	selectin E	Homo sapiens	64-105
8629998-2	1996	We report that MIII (but not OLT) is a nontoxic inhibitor of long terminal repeat (LTR)-driven expression of beta-galactosidase in phorbol-12-myristate-13-acetate (PMA)-stimulated and unstimulated 293.27.2 cells (ED50 = 14 +/- 1 and 41 +/- 4 microM, respectively).	Tetradecanoylphorbol Acetate	164-167	galactosidase beta 1	Homo sapiens	109-127
8622872-3	1996	TPA induced p21 in ML1, K562 and HL60 leukemia cells, whereas OA induced p21 in SW480 and GM4723 carcinoma cells as well as in leukemic cells.	Tetradecanoylphorbol Acetate	0-3	interleukin 17F	Homo sapiens	19-22
2013762-0	1991	Phorbol myristate acetate and 8-bromo-cyclic AMP-induced phosphorylation of glial fibrillary acidic protein and vimentin in astrocytes: comparison of phosphorylation sites.	Tetradecanoylphorbol Acetate	0-25	vimentin	Homo sapiens	112-120
8928729-8	1996	Pretreatment of the cells with calmodulin antagonists W-13 or calmidazolium, prevented the PMA-induced inhibition of taurine uptake.	Tetradecanoylphorbol Acetate	91-94	calmodulin 1	Rattus norvegicus	31-41
2013762-4	1991	Treatment with PMA increased 32P incorporation into all the peptide fragments that were phosphorylated by 8-BR on both vimentin and GFAP; however, PMA also stimulated phosphorylation of additional fragments of both proteins.	Tetradecanoylphorbol Acetate	15-18	vimentin	Homo sapiens	119-127
8928792-7	1996	Time-course studies revealed maximal activation of the HDC promoter after 12-36 h. Direct stimulation of protein kinase C (PKC) with the phorbol ester phorbol 12-myristate 13-acetate (PMA) substantially elevated rat HDC promoter activity, whereas induction of Ca2+ -dependent signaling pathways with thapsigargin was without effect.	Tetradecanoylphorbol Acetate	151-182	histidine decarboxylase	Rattus norvegicus	55-58
1850101-7	1991	After both 1 and 24 h, tyrphostin was a less effective inhibitor of tyrosine kinase activity than the potent tumor promoter 12-O-tetradecanoyl phorbol-13-acetate, which almost completely blocked EGF receptor autophosphorylation.	Tetradecanoylphorbol Acetate	124-161	epidermal growth factor	Homo sapiens	195-198
8928792-7	1996	Time-course studies revealed maximal activation of the HDC promoter after 12-36 h. Direct stimulation of protein kinase C (PKC) with the phorbol ester phorbol 12-myristate 13-acetate (PMA) substantially elevated rat HDC promoter activity, whereas induction of Ca2+ -dependent signaling pathways with thapsigargin was without effect.	Tetradecanoylphorbol Acetate	151-182	histidine decarboxylase	Rattus norvegicus	216-219
8928792-7	1996	Time-course studies revealed maximal activation of the HDC promoter after 12-36 h. Direct stimulation of protein kinase C (PKC) with the phorbol ester phorbol 12-myristate 13-acetate (PMA) substantially elevated rat HDC promoter activity, whereas induction of Ca2+ -dependent signaling pathways with thapsigargin was without effect.	Tetradecanoylphorbol Acetate	184-187	histidine decarboxylase	Rattus norvegicus	55-58
1905005-3	1991	We found that H-ras has the unique ability to inhibit c-fos induction by TPA.	Tetradecanoylphorbol Acetate	73-76	HRas proto-oncogene, GTPase	Homo sapiens	14-19
8928792-7	1996	Time-course studies revealed maximal activation of the HDC promoter after 12-36 h. Direct stimulation of protein kinase C (PKC) with the phorbol ester phorbol 12-myristate 13-acetate (PMA) substantially elevated rat HDC promoter activity, whereas induction of Ca2+ -dependent signaling pathways with thapsigargin was without effect.	Tetradecanoylphorbol Acetate	184-187	histidine decarboxylase	Rattus norvegicus	216-219
8630101-8	1996	In rabbit articular chondrocyte cultures, administration of transforming growth factor beta 1 (TGF beta 1) and bone morphogenetic protein 2 increased SPARC levels at 24-48 hours, whereas interleukin-lbeta (IL-1 beta), IL-1 alpha, tumor necrosis factor alpha, lipopolysaccharide, phorbol myristate acetate, basic fibroblast growth factor, and dexamethasone decreased SPARC levels at 24-72 hours.	Tetradecanoylphorbol Acetate	279-304	bone morphogenetic protein 2	Oryctolagus cuniculus	111-139
8625496-2	1996	Although numerous works have extensively investigated the induction mechanisms of c-jun by UV, hydrogen peroxide or 12-O-tetradecanoylphorbol-13-acetate, the mechanism induced by alkylating agents has received little attention.	Tetradecanoylphorbol Acetate	116-152	jun proto-oncogene	Mus musculus	82-87
1849761-4	1991	Exposure to the phorbol ester phorbol 12-myristate 13-acetate (TPA) caused enhancement of granulocyte-macrophage colony-stimulating factor (GM-CSF) message level in lung cancer cells and in control fibroblasts but elevated levels persisted far longer in the tumor cells.	Tetradecanoylphorbol Acetate	30-61	colony stimulating factor 2	Homo sapiens	90-138
1849761-4	1991	Exposure to the phorbol ester phorbol 12-myristate 13-acetate (TPA) caused enhancement of granulocyte-macrophage colony-stimulating factor (GM-CSF) message level in lung cancer cells and in control fibroblasts but elevated levels persisted far longer in the tumor cells.	Tetradecanoylphorbol Acetate	30-61	colony stimulating factor 2	Homo sapiens	140-146
1849761-4	1991	Exposure to the phorbol ester phorbol 12-myristate 13-acetate (TPA) caused enhancement of granulocyte-macrophage colony-stimulating factor (GM-CSF) message level in lung cancer cells and in control fibroblasts but elevated levels persisted far longer in the tumor cells.	Tetradecanoylphorbol Acetate	63-66	colony stimulating factor 2	Homo sapiens	90-138
8618024-5	1996	The activity of the eta isoform also remained unchanged after the 12-O-tetradecanoyl-phorbol-13-acetate treatment, as judged by binding ATP analog, autophosphorylation, and phosphorylation of an exogenous substrate.	Tetradecanoylphorbol Acetate	66-103	endothelin receptor type A	Homo sapiens	20-23
1849761-4	1991	Exposure to the phorbol ester phorbol 12-myristate 13-acetate (TPA) caused enhancement of granulocyte-macrophage colony-stimulating factor (GM-CSF) message level in lung cancer cells and in control fibroblasts but elevated levels persisted far longer in the tumor cells.	Tetradecanoylphorbol Acetate	63-66	colony stimulating factor 2	Homo sapiens	140-146
8771559-9	1996	In protein kinase C-downregulated cells pretreated with PMA for 24 h, the stimulatory effect of PACAP on TH and DBH gene expression was diminished.	Tetradecanoylphorbol Acetate	56-59	adenylate cyclase activating polypeptide 1	Homo sapiens	96-101
1661233-7	1991	The potent GnRH antagonist [Ac-D-p-Cl-Phe1.2, D-Trp3, D-Lys6, D-Ala10]GnRH, which completely inhibited GnRHa-stimulated LH release with ID50 of 6.8 nM, also reduced maximum TPA-stimulated LH release by about 50%.	Tetradecanoylphorbol Acetate	173-176	gonadotropin releasing hormone 1	Rattus norvegicus	11-15
1661233-7	1991	The potent GnRH antagonist [Ac-D-p-Cl-Phe1.2, D-Trp3, D-Lys6, D-Ala10]GnRH, which completely inhibited GnRHa-stimulated LH release with ID50 of 6.8 nM, also reduced maximum TPA-stimulated LH release by about 50%.	Tetradecanoylphorbol Acetate	173-176	gonadotropin releasing hormone 1	Rattus norvegicus	70-74
1661233-10	1991	Furthermore, the partial inhibition of TPA-stimulated LH release by a GnRH antagonist suggests that the pathway(s), specifically connected with LH release in the diverse effects of C kinase, might be locked by the continuous receptor inactivation by antagonist and indicates the complicated pathways which diverge from the receptor and converge into specific cellular response.	Tetradecanoylphorbol Acetate	39-42	gonadotropin releasing hormone 1	Rattus norvegicus	70-74
8631809-5	1996	In transient transfection assays, both multicopy NFAT- and IL-2 promoter-beta-galactosidase reporter gene constructs could be activated by phorbol 12-myristate 13-acetate (PMA)/alpha-CD28 stimulation, and this activation was resistant to CsA.	Tetradecanoylphorbol Acetate	139-170	galactosidase beta 1	Homo sapiens	73-91
1651030-10	1991	In a similar fashion, superoxide generation and secretion of elastase and lysozyme in response to zymosan and phorbol myristate acetate were substantially higher than in the control dog.	Tetradecanoylphorbol Acetate	110-135	lysozyme	Canis lupus familiaris	74-82
8631809-5	1996	In transient transfection assays, both multicopy NFAT- and IL-2 promoter-beta-galactosidase reporter gene constructs could be activated by phorbol 12-myristate 13-acetate (PMA)/alpha-CD28 stimulation, and this activation was resistant to CsA.	Tetradecanoylphorbol Acetate	139-170	CD28 molecule	Homo sapiens	183-187
1848559-6	1991	Using the PKC activator phorbol myristate acetate (PMA) as the agonist, we found that activation of the respiratory burst oxidase was associated with translocation of cytosolic p47-phox and p67-phox to the plasma membrane as well as redistribution of p47-phox to the Triton-insoluble cytoskeleton.	Tetradecanoylphorbol Acetate	24-49	pleckstrin	Homo sapiens	177-180
8631809-5	1996	In transient transfection assays, both multicopy NFAT- and IL-2 promoter-beta-galactosidase reporter gene constructs could be activated by phorbol 12-myristate 13-acetate (PMA)/alpha-CD28 stimulation, and this activation was resistant to CsA.	Tetradecanoylphorbol Acetate	172-175	galactosidase beta 1	Homo sapiens	73-91
1848559-6	1991	Using the PKC activator phorbol myristate acetate (PMA) as the agonist, we found that activation of the respiratory burst oxidase was associated with translocation of cytosolic p47-phox and p67-phox to the plasma membrane as well as redistribution of p47-phox to the Triton-insoluble cytoskeleton.	Tetradecanoylphorbol Acetate	51-54	pleckstrin	Homo sapiens	177-180
8631809-5	1996	In transient transfection assays, both multicopy NFAT- and IL-2 promoter-beta-galactosidase reporter gene constructs could be activated by phorbol 12-myristate 13-acetate (PMA)/alpha-CD28 stimulation, and this activation was resistant to CsA.	Tetradecanoylphorbol Acetate	172-175	CD28 molecule	Homo sapiens	183-187
8621441-5	1996	The activity of Raf-1, measured by immune complex kinase assay, revealed that platelet-derived growth factor and phorbol 12-myristate 13-acetate both stimulated Raf-1 activity, while thrombin and endothelin did not appreciably stimulate Raf-1.	Tetradecanoylphorbol Acetate	113-144	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	16-21
8621441-5	1996	The activity of Raf-1, measured by immune complex kinase assay, revealed that platelet-derived growth factor and phorbol 12-myristate 13-acetate both stimulated Raf-1 activity, while thrombin and endothelin did not appreciably stimulate Raf-1.	Tetradecanoylphorbol Acetate	113-144	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	161-166
8621441-5	1996	The activity of Raf-1, measured by immune complex kinase assay, revealed that platelet-derived growth factor and phorbol 12-myristate 13-acetate both stimulated Raf-1 activity, while thrombin and endothelin did not appreciably stimulate Raf-1.	Tetradecanoylphorbol Acetate	113-144	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	161-166
8601464-3	1996	PMA did not induce liberation of [3H]AA although it induced beta-TG release and aggregation; preincubation with PMA did not modify significantly the amounts of [3H]AA and beta-TG released by thrombin or AlF4-.	Tetradecanoylphorbol Acetate	0-3	pro-platelet basic protein	Homo sapiens	60-67
8703583-7	1996	In addition, FLG 29.1 cells released in the conditioned medium IGFBP-2 and IGFBP-4, whose expression was increased by TPA treatment as demonstrated by ligand and immunoblot analyses.	Tetradecanoylphorbol Acetate	118-121	insulin like growth factor binding protein 2	Homo sapiens	63-70
8605944-4	1996	Flow cytometric analysis revealed that FasL is expressed on the surface of B cells upon stimulation with either lipopolysaccharide or phorbol 12-myristate 13-acetate/ionomycin.	Tetradecanoylphorbol Acetate	134-165	Fas ligand (TNF superfamily, member 6)	Mus musculus	39-43
8671615-5	1996	We have previously shown that proper cross-linking of TCR-CD3 with LFA-1, CD4 or CD8 inhibited glucocorticoid-induced thymocyte apoptosis in vitro, and that a proper combination of the calcium ionophore, ionomycin and the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), mimicked the inhibitory effect.	Tetradecanoylphorbol Acetate	256-287	CD3 antigen, epsilon polypeptide	Mus musculus	58-61
8597533-8	1996	The peaks of Cx26 and Cx43 expression and Cx31.1 inhibition appeared 12 h after TPA application and 24 h after OA and chrysarobin application.	Tetradecanoylphorbol Acetate	80-83	gap junction protein, alpha 3	Mus musculus	22-26
8562972-0	1996	TPA-induced arrest of erythroid differentiation is coupled with downregulation of GATA-1 and upregulation of GATA-2 in an erythroid cell line SAM-1.	Tetradecanoylphorbol Acetate	0-3	GATA binding protein 2	Homo sapiens	109-115
8562972-4	1996	In this report, we performed specific and quantitative measurements of GATA-1 and GATA-2 protein in a new erythroid cell line, SAM-1, after treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	155-191	GATA binding protein 2	Homo sapiens	82-88
8562972-4	1996	In this report, we performed specific and quantitative measurements of GATA-1 and GATA-2 protein in a new erythroid cell line, SAM-1, after treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	193-196	GATA binding protein 2	Homo sapiens	82-88
8562972-5	1996	On the basis of these measurements, we show that TPA-induced arrest of erythroid differentiation is coupled with the upregulation of GATA-2 protein, as well as the downregulation of GATA-1 protein.	Tetradecanoylphorbol Acetate	49-52	GATA binding protein 2	Homo sapiens	133-139
8633191-4	1996	The expression of the IL-2R by lymphocytes was also resistant to NDGA concentrations that effectively blocked the mitogenic effects of TPA or bryostatin, but could be inhibited by higher concentrations of NDGA (IC50 = 8 microM).	Tetradecanoylphorbol Acetate	135-138	interleukin 2 receptor subunit alpha	Homo sapiens	22-27
8579606-5	1996	The suppressive effect of CT on hydroperoxide production was reversed by further addition of H7 or by pretreatment with phorbol 12-myristate 13-acetate for 24 h. These results suggest that CT prevents CCl4-induced oxyradical production and cellular damage through activation of protein kinase C in hepatocytes.	Tetradecanoylphorbol Acetate	120-151	calcitonin-related polypeptide alpha	Rattus norvegicus	189-191
8579615-7	1996	ACAT is expressed in mouse macrophages as a approximately 3.6 kB transcript and the expression is upregulated in human THP-1 cells treated with PMA.	Tetradecanoylphorbol Acetate	144-147	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	0-4
1472015-8	1992	The present report describes the induction of LTC4 synthase activity during differentiation of human erythroleukemia (HEL) cells by the protein kinase C stimulator 12-O-tetradecanoyl phorbol 13-acetate (TPA), ligands of the steroid-thyroid hormone receptor superfamily: all-trans-retinoic acid (RA) and 1 alpha, 25-dihydroxy-vitamin D3 and in addition dimethylsulfoxide (DMSO).	Tetradecanoylphorbol Acetate	164-201	leukotriene C4 synthase	Homo sapiens	46-59
1472015-8	1992	The present report describes the induction of LTC4 synthase activity during differentiation of human erythroleukemia (HEL) cells by the protein kinase C stimulator 12-O-tetradecanoyl phorbol 13-acetate (TPA), ligands of the steroid-thyroid hormone receptor superfamily: all-trans-retinoic acid (RA) and 1 alpha, 25-dihydroxy-vitamin D3 and in addition dimethylsulfoxide (DMSO).	Tetradecanoylphorbol Acetate	203-206	leukotriene C4 synthase	Homo sapiens	46-59
8602119-4	1996	Chronic ethanol exposure also increased the in situ phosphorylation of MARCKS in permeabilized astrocytes both in the absence or presence of the PKC activator, phorbol 12 -myristate 13 -acetate (PMA).	Tetradecanoylphorbol Acetate	160-193	myristoylated alanine rich protein kinase C substrate	Homo sapiens	71-77
8602119-4	1996	Chronic ethanol exposure also increased the in situ phosphorylation of MARCKS in permeabilized astrocytes both in the absence or presence of the PKC activator, phorbol 12 -myristate 13 -acetate (PMA).	Tetradecanoylphorbol Acetate	195-198	myristoylated alanine rich protein kinase C substrate	Homo sapiens	71-77
21594328-1	1996	The effects of genistein, a soybean isoflavone, on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced expression of c-fos and c-jun in CD-1 mouse skin have been investigated.	Tetradecanoylphorbol Acetate	51-88	jun proto-oncogene	Mus musculus	127-132
1292682-5	1992	PMA induced a monophasic slow and sustained increase in pHi.	Tetradecanoylphorbol Acetate	0-3	glucose-6-phosphate isomerase	Rattus norvegicus	56-59
21594328-1	1996	The effects of genistein, a soybean isoflavone, on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced expression of c-fos and c-jun in CD-1 mouse skin have been investigated.	Tetradecanoylphorbol Acetate	90-93	jun proto-oncogene	Mus musculus	127-132
21594328-2	1996	A promoting dose (8.5 mu mol) of TPA significantly increases transcript levels of c-fos, and 2.7 and 3.2 kb c-jun mRNA in mouse skin by 7.0-, 3.2-, and 1.7-fold, respectively.	Tetradecanoylphorbol Acetate	33-36	jun proto-oncogene	Mus musculus	108-113
21594328-5	1996	Genistein exhibited only a weak suppressive effect on TPA-induced c-jun mRNA expression.	Tetradecanoylphorbol Acetate	54-57	jun proto-oncogene	Mus musculus	66-71
8530417-6	1995	In vitro run-off transcription assays indicated that transcription of the prodynorphin gene was increased both in nuclei isolated from phorbol ester-treated myocytes and in nuclei isolated from control cells and then exposed to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	228-259	prodynorphin	Rattus norvegicus	74-86
1446598-2	1992	Dose-response and time-course studies revealed that TPA (10(-8) M) acutely increased GnRH secretion 3-fold at 3-6 h, which then declined to baseline at 24 h, while it progressively decreased GnRH mRNA levels by 50% and 70% at 6 and 24 h, respectively.	Tetradecanoylphorbol Acetate	52-55	gonadotropin releasing hormone 1	Mus musculus	85-89
1446598-2	1992	Dose-response and time-course studies revealed that TPA (10(-8) M) acutely increased GnRH secretion 3-fold at 3-6 h, which then declined to baseline at 24 h, while it progressively decreased GnRH mRNA levels by 50% and 70% at 6 and 24 h, respectively.	Tetradecanoylphorbol Acetate	52-55	gonadotropin releasing hormone 1	Mus musculus	191-195
1446598-4	1992	This brief exposure to TPA also resulted in a decrease (60%) in GnRH mRNA levels at 6 h, with a 1.5- to 2-fold increase in GnRH secretion compared to control values, suggesting that activation of PKC decreases the pretranslational expression of GnRH while increasing GnRH secretion.	Tetradecanoylphorbol Acetate	23-26	gonadotropin releasing hormone 1	Mus musculus	64-68
1446598-4	1992	This brief exposure to TPA also resulted in a decrease (60%) in GnRH mRNA levels at 6 h, with a 1.5- to 2-fold increase in GnRH secretion compared to control values, suggesting that activation of PKC decreases the pretranslational expression of GnRH while increasing GnRH secretion.	Tetradecanoylphorbol Acetate	23-26	gonadotropin releasing hormone 1	Mus musculus	123-127
1446598-4	1992	This brief exposure to TPA also resulted in a decrease (60%) in GnRH mRNA levels at 6 h, with a 1.5- to 2-fold increase in GnRH secretion compared to control values, suggesting that activation of PKC decreases the pretranslational expression of GnRH while increasing GnRH secretion.	Tetradecanoylphorbol Acetate	23-26	gonadotropin releasing hormone 1	Mus musculus	123-127
8830308-4	1995	Levels of TRH mRNA were raised after the first hour of dBcAMP or 2 h of TPA treatment and were still increased at 24 h. These results suggest a neural regulation of TRH biosynthesis.	Tetradecanoylphorbol Acetate	72-75	thyrotropin releasing hormone	Rattus norvegicus	10-13
8830308-4	1995	Levels of TRH mRNA were raised after the first hour of dBcAMP or 2 h of TPA treatment and were still increased at 24 h. These results suggest a neural regulation of TRH biosynthesis.	Tetradecanoylphorbol Acetate	72-75	thyrotropin releasing hormone	Rattus norvegicus	165-168
1446598-4	1992	This brief exposure to TPA also resulted in a decrease (60%) in GnRH mRNA levels at 6 h, with a 1.5- to 2-fold increase in GnRH secretion compared to control values, suggesting that activation of PKC decreases the pretranslational expression of GnRH while increasing GnRH secretion.	Tetradecanoylphorbol Acetate	23-26	gonadotropin releasing hormone 1	Mus musculus	123-127
1446598-7	1992	We conclude that TPA, by activating the PKC pathway, acutely increases GnRH secretion, but dramatically decreases GnRH gene expression.	Tetradecanoylphorbol Acetate	17-20	gonadotropin releasing hormone 1	Mus musculus	71-75
7594491-7	1995	PMA-induced pulmonary edema (lung wet:dry ratio increased from 8.8 +/- 0.7 to 18.8 +/- 4.4) was inhibited by NIF (10.0 +/- 1.0).	Tetradecanoylphorbol Acetate	0-3	S100 calcium binding protein A8	Homo sapiens	109-112
1446598-7	1992	We conclude that TPA, by activating the PKC pathway, acutely increases GnRH secretion, but dramatically decreases GnRH gene expression.	Tetradecanoylphorbol Acetate	17-20	gonadotropin releasing hormone 1	Mus musculus	114-118
7594491-10	1995	Moreover, NIF prevented PMA-induced neutrophil adhesion to fibrinogen, a CD11b/CD18-dependent event, but produced a smaller decrease in adherence to endothelial cells, which also involves CD11a/CD18 integrins.	Tetradecanoylphorbol Acetate	24-27	S100 calcium binding protein A8	Homo sapiens	10-13
8521477-6	1995	Mice lacking COX-2 have normal inflammatory responses to treatments with tetradecanoyl phorbol acetate or with arachidonic acid.	Tetradecanoylphorbol Acetate	73-102	prostaglandin-endoperoxide synthase 2	Mus musculus	13-18
1281302-4	1992	Transcriptional activation of the c-jun, junB and c-fos genes following TPA/serum induction was unaffected and efficient transactivation of AP-1 reporter constructs was demonstrated in these cells.	Tetradecanoylphorbol Acetate	72-75	jun B proto-oncogene	Mus musculus	41-45
1281302-4	1992	Transcriptional activation of the c-jun, junB and c-fos genes following TPA/serum induction was unaffected and efficient transactivation of AP-1 reporter constructs was demonstrated in these cells.	Tetradecanoylphorbol Acetate	72-75	FBJ osteosarcoma oncogene	Mus musculus	50-55
8595373-14	1995	In addition the effect of CD28 co-stimulation on IL-2 mRNA stabilisation was demonstrated by the maintenance of a high frequency of IL-2 expressing CD4 T cells and an elevated level of mRNA per cell for prolonged period after PMA+Io stimulation.	Tetradecanoylphorbol Acetate	226-229	CD28 molecule	Homo sapiens	26-30
7589260-9	1995	TPA caused a small increase in levels of cyclin D1 and had little effect on cyclin E, suggesting these G1 cyclins were not limiting.	Tetradecanoylphorbol Acetate	0-3	cyclin D1	Homo sapiens	41-50
1429733-6	1992	PMA-stimulated exocytosis was inhibited by staurosporine or a PKC pseudosubstrate antagonist peptide, but was not affected by GDP.	Tetradecanoylphorbol Acetate	0-3	protein kinase C gamma	Homo sapiens	62-65
7589260-13	1995	These results demonstrate that TPA blocks the G1/S transition in Demel melanoma cells in late G1 by mechanisms which regulate phosphorylation and activation of the CDK2 kinase.	Tetradecanoylphorbol Acetate	31-34	cyclin dependent kinase 2	Homo sapiens	164-168
7591091-3	1995	To investigate the mechanisms accounting for the impaired responses to gamma interferon, a model system for examining overall changes in protein tyrosine phosphorylation, activation of Jak1 and Jak2 and phosphorylation of Stat1 was developed in phorbol 12-myristate 13-acetate-differentiated U-937 cells.	Tetradecanoylphorbol Acetate	245-276	Janus kinase 2	Homo sapiens	194-198
1445344-5	1992	IGF-I and EGF stimulated the transcriptional activity dependent on the phorbol 12-myristate 13-acetate-responsive element (TRE) to the same extent, when measured by the chloramphenicol acetyl transferase activity of a transiently transfected multiple TRE construct.	Tetradecanoylphorbol Acetate	71-102	epidermal growth factor	Homo sapiens	10-13
8750787-6	1995	In mastocytoma cells, we demonstrated that the induction of HDC activity and HDC mRNA synergistically occurred upon treatment with dexamethasone + TPA, and also with cAMP + Ca2+.	Tetradecanoylphorbol Acetate	147-150	histidine decarboxylase	Mus musculus	60-63
1332686-5	1992	Whereas preincubation with PMA completely eliminated PMA-induced PAI-1 synthesis and secretion in both CCL64 and BSC-1 cells, this treatment had no effect on TGF-beta- and EGF-induced PAI-1 levels.	Tetradecanoylphorbol Acetate	27-30	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	65-70
1385002-0	1992	Non-promoting 12-deoxyphorbol 13-esters as potent inhibitors of phorbol 12-myristate 13-acetate-induced acute and chronic biological responses in CD-1 mouse skin.	Tetradecanoylphorbol Acetate	64-95	CD1 antigen complex	Mus musculus	146-150
8750787-6	1995	In mastocytoma cells, we demonstrated that the induction of HDC activity and HDC mRNA synergistically occurred upon treatment with dexamethasone + TPA, and also with cAMP + Ca2+.	Tetradecanoylphorbol Acetate	147-150	histidine decarboxylase	Mus musculus	77-80
1385002-1	1992	In previous experiments, pretreatment of CD-1 mouse skin with prostratin (12-deoxyphorbol 13-acetate) inhibited hyperplasia, induction of ornithine decarboxylase and edema in response to acute treatment with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	208-239	CD1 antigen complex	Mus musculus	41-45
1385002-1	1992	In previous experiments, pretreatment of CD-1 mouse skin with prostratin (12-deoxyphorbol 13-acetate) inhibited hyperplasia, induction of ornithine decarboxylase and edema in response to acute treatment with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	241-244	CD1 antigen complex	Mus musculus	41-45
8575515-6	1995	IS2 and IS3 showed topical anti-inflammatory activity against the TPA-induced ear inflammation in mice, with similar effects on oedema and a higher inhibition of IS3 on leukocyte migration, estimated as myeloperoxidase activity in supernatants of ear homogenates.	Tetradecanoylphorbol Acetate	66-69	chromodomain helicase DNA binding protein 7	Homo sapiens	8-11
1292632-3	1992	After stimulation with phorbol myristate acetate LC express RNA for interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta) and produce proteins but do not secrete them at detectable levels.	Tetradecanoylphorbol Acetate	23-48	interleukin 1 alpha	Homo sapiens	68-87
1292632-3	1992	After stimulation with phorbol myristate acetate LC express RNA for interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta) and produce proteins but do not secrete them at detectable levels.	Tetradecanoylphorbol Acetate	23-48	interleukin 1 alpha	Homo sapiens	89-99
7579389-5	1995	Downregulation of protein kinase C (PKC) by chronic exposure of stromal cells to the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA; 400 nmol/L) did not effect c-jun expression induced by arachidonate.	Tetradecanoylphorbol Acetate	138-141	jun proto-oncogene	Mus musculus	170-175
1337986-3	1992	Our data show a definite downregulation of IL-6R and gp130 expression by TPA in U266 and BMNH at both mRNA and cell surface protein levels.	Tetradecanoylphorbol Acetate	73-76	interleukin 6 cytokine family signal transducer	Homo sapiens	53-58
7579389-6	1995	Moreover, pretreatment of cells with the PKC inhibitor, calphostin C (1 mumol/L), caused a marked decrease of c-jun expression induced by TPA, but had no influence on c-jun expression induced by arachidonate.	Tetradecanoylphorbol Acetate	138-141	jun proto-oncogene	Mus musculus	110-115
7560079-10	1995	TPA-treated MCF-7-PKC-alpha cells expressed gadd-45 which occurred before the onset of apoptosis.	Tetradecanoylphorbol Acetate	0-3	growth arrest and DNA damage inducible alpha	Homo sapiens	44-51
8572580-4	1995	12-O-tetradecanoylphorbol-13-acetate (TPA), a direct activator of protein kinase C (PKC), elevated dose and time dependently the level of asparagine synthetase mRNA even in Eagle"s minimum essential medium with alpha modification (MEM alpha) that contains protein-constituting 20 amino acids and is supplemented with 3.3 mM asparagine.	Tetradecanoylphorbol Acetate	0-36	asparagine synthetase	Mus musculus	138-159
1474095-1	1992	Products of cyclooxygenase activity have been proposed to mediate the pulmonary hypertension and increased microvascular permeability associated with phorbol myristate acetate- (PMA) induced acute lung injury.	Tetradecanoylphorbol Acetate	150-175	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	12-26
8572580-4	1995	12-O-tetradecanoylphorbol-13-acetate (TPA), a direct activator of protein kinase C (PKC), elevated dose and time dependently the level of asparagine synthetase mRNA even in Eagle"s minimum essential medium with alpha modification (MEM alpha) that contains protein-constituting 20 amino acids and is supplemented with 3.3 mM asparagine.	Tetradecanoylphorbol Acetate	38-41	asparagine synthetase	Mus musculus	138-159
1474095-1	1992	Products of cyclooxygenase activity have been proposed to mediate the pulmonary hypertension and increased microvascular permeability associated with phorbol myristate acetate- (PMA) induced acute lung injury.	Tetradecanoylphorbol Acetate	178-181	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	12-26
7641182-2	1995	Both bryostatin 1 and PMA induced inhibition of cyclin-dependent kinase 2 (cdk2) activity.	Tetradecanoylphorbol Acetate	22-25	cyclin dependent kinase 2	Homo sapiens	48-73
1474095-7	1992	Both the selective Tx synthase inhibitor, OKY-046 (7 x 10(-4) M, n = 6), and the cyclooxygenase inhibitor, indomethacin (10(-4) M, n = 7), prevented the PMA-induced increase in TxB2, but neither compound attenuated the PMA-induced increase in Kfc.	Tetradecanoylphorbol Acetate	153-156	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	81-95
1331177-4	1992	In the mouse AT-20 pituitary tumor cell line, IL-2 mRNA expression was detected after stimulation with corticotropin-releasing hormone or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	138-163	interleukin 2	Mus musculus	46-50
7641182-2	1995	Both bryostatin 1 and PMA induced inhibition of cyclin-dependent kinase 2 (cdk2) activity.	Tetradecanoylphorbol Acetate	22-25	cyclin dependent kinase 2	Homo sapiens	75-79
1402691-10	1992	Comparison of the predicted amino acid sequence of 8.1.1 with proteins in the National Biomedical Research Foundation (NBRF) data base showed that gp38 is very closely related to the early response protein OTS-8 obtained from a cDNA library of tumor promoting agent (TPA)-induced murine osteoblastic cell line, MC3T3-E1.	Tetradecanoylphorbol Acetate	267-270	podoplanin	Mus musculus	147-151
7641182-5	1995	The level of growth inhibition induced by these two compounds correlated with the degree of cdk2 dephosphorylation as follows: bryostatin 1, 60%; PMA, 100%.	Tetradecanoylphorbol Acetate	146-149	cyclin dependent kinase 2	Homo sapiens	92-96
1402691-10	1992	Comparison of the predicted amino acid sequence of 8.1.1 with proteins in the National Biomedical Research Foundation (NBRF) data base showed that gp38 is very closely related to the early response protein OTS-8 obtained from a cDNA library of tumor promoting agent (TPA)-induced murine osteoblastic cell line, MC3T3-E1.	Tetradecanoylphorbol Acetate	267-270	podoplanin	Mus musculus	206-211
7657697-5	1995	When 12-o-tetradecanoyl phorbol acetate was added to muscle cell cultures to induce the sequential disassembly of thin and thick filaments, transglutaminase was strictly colocalized with the myosin thick filaments even in the myosacs, of which most of the thin filaments were disrupted.	Tetradecanoylphorbol Acetate	5-39	myosin, heavy chain 15	Gallus gallus	191-197
20732162-6	1992	D), respectively, indicated that the induction of ODC by TPA was totally dependent on protein synthesis and was also dependent on transcriptional events.	Tetradecanoylphorbol Acetate	57-60	ornithine decarboxylase 1	Rattus norvegicus	50-53
2005129-10	1991	Endogenous protein kinase C activity in macrophages was depleted by treatment with 12-O-tetradecanoylphorbol-13-acetate for 24 h. GM-CSF increased Egr-1 mRNA in protein kinase C-depleted macrophages, whereas the stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate on Egr-1 was blocked.	Tetradecanoylphorbol Acetate	234-270	early growth response 1	Mus musculus	147-152
20732162-7	1992	Sphingosine and H-7 (1-(5-isoquinolinyl-sulphonyl)-2-methylpiperazine) inhibited the induction of ODC by TPA indicating the involvement of protein kinase C (PK-C) in this process.	Tetradecanoylphorbol Acetate	105-108	ornithine decarboxylase 1	Rattus norvegicus	98-101
7654720-11	1995	In addition, 8-Br-cAMP and phorbol myristate acetate were found to increase SCPx promoter activity in a host cell-specific manner.	Tetradecanoylphorbol Acetate	27-52	sterol carrier protein 2	Homo sapiens	76-80
20732162-8	1992	Pre-incubation of the hepatocytes with TPA, a procedure which down-regulates PK-C, decreased the induction of ODC by a subsequent new exposure to TPA, but had no effect on the induction of ODC caused by asparagine in this system.	Tetradecanoylphorbol Acetate	39-42	ornithine decarboxylase 1	Rattus norvegicus	110-113
20732162-8	1992	Pre-incubation of the hepatocytes with TPA, a procedure which down-regulates PK-C, decreased the induction of ODC by a subsequent new exposure to TPA, but had no effect on the induction of ODC caused by asparagine in this system.	Tetradecanoylphorbol Acetate	146-149	ornithine decarboxylase 1	Rattus norvegicus	110-113
2001450-8	1991	Costimulation of Jurkat cells with both phorbol myristate acetate and PHA caused both a transient increase in IL-3 gene transcription, which is dependent on new protein synthesis, and also a transient increase in mRNA stability.	Tetradecanoylphorbol Acetate	40-65	interleukin 3	Homo sapiens	110-114
7583274-4	1995	Subsequently, we determined that treatment (24 h) of the neurons with either dibutyryl cAMP (1 mM) or phorbol 12-myristate 13-acetate (2 microM) increased CGRP mRNA content 2.2 +/- 0.4 (n = 6, p &lt; 0.03) and 3.0 +/- 0.6-fold (n = 6, P &lt; 0.02) respectively, while secreted iCGRP levels were increased 1.8 +/- 0.2 (n = 14, P &lt; 0.005) and 4.5 +/- 1.0 (n = 14, P &lt; 0.001)-fold over control levels.	Tetradecanoylphorbol Acetate	102-133	calcitonin-related polypeptide alpha	Rattus norvegicus	155-159
1900938-6	1991	Inhibition of protein kinase C activity by prolonged stimulation with phorbol 12-myristate 13-acetate or the protein kinase inhibitor H7 prior to irradiation attenuated the increase in EGR1 and JUN transcripts.	Tetradecanoylphorbol Acetate	70-101	early growth response 1	Homo sapiens	185-189
1280321-2	1992	In bovine adrenal zona glomerulosa cells, TPA (phorbol ester) induces a marked inhibition of the ANF-stimulated cGMP accumulation as well as of the membrane ANF-sensitive guanylate cyclase catalytic activity without any change in the binding capacity or affinity for 125I-ANF.	Tetradecanoylphorbol Acetate	42-45	natriuretic peptide A	Bos taurus	97-100
1280321-2	1992	In bovine adrenal zona glomerulosa cells, TPA (phorbol ester) induces a marked inhibition of the ANF-stimulated cGMP accumulation as well as of the membrane ANF-sensitive guanylate cyclase catalytic activity without any change in the binding capacity or affinity for 125I-ANF.	Tetradecanoylphorbol Acetate	42-45	natriuretic peptide A	Bos taurus	157-160
1280321-2	1992	In bovine adrenal zona glomerulosa cells, TPA (phorbol ester) induces a marked inhibition of the ANF-stimulated cGMP accumulation as well as of the membrane ANF-sensitive guanylate cyclase catalytic activity without any change in the binding capacity or affinity for 125I-ANF.	Tetradecanoylphorbol Acetate	42-45	natriuretic peptide A	Bos taurus	157-160
2001346-5	1991	Optimal stimulation of LPL mRNA occurred when dexamethasone was added 24 h after induction with PMA.	Tetradecanoylphorbol Acetate	96-99	lipoprotein lipase	Homo sapiens	23-26
7608202-3	1995	Receptor-dependent activation of NFAT was mimicked by the combination of the protein kinase C activator phorbol myristate acetate and the calcium ionophore ionomycin.	Tetradecanoylphorbol Acetate	104-129	nuclear factor of activated T-cells 5	Rattus norvegicus	33-37
2009973-4	1991	The action of these proteins to induce M-CSF transcript levels was dependent on synthesis of new proteins and was not mediated by protein kinase C (PKC) stimulation as depletion of cellular PKC pools by prolonged exposure of fibroblasts to phorbolester TPA did not prevent factor induced synthesis of M-CSF transcripts.	Tetradecanoylphorbol Acetate	253-256	colony stimulating factor 1	Homo sapiens	39-44
1327097-13	1992	Other SMC mitogens (epidermal growth factor, transforming growth factor-beta 1, basic fibroblast growth factor, platelet-derived growth factor, and phorbol 12-myristate 13-acetate) increased u-PAR expression on SMCs six- to 20-fold while concomitantly increasing Kd four- to 10-fold.	Tetradecanoylphorbol Acetate	148-179	plasminogen activator, urokinase receptor	Homo sapiens	191-196
7619067-2	1995	Acute inflammation and epidermal hyperplasia, (hyperplastic transformation), as evoked in adult mouse skin in vivo by wounding or by the phorbol ester phorbol 12-myristate 13-acetate (PMA), resulted in a transient induction of PGHS-2 expression while PGHS-1 remained unchanged.	Tetradecanoylphorbol Acetate	151-182	prostaglandin-endoperoxide synthase 2	Mus musculus	227-233
1991328-7	1991	A comparison of the inhibitory effects of anti-beta 2m MoAb on activation by different stimuli revealed that PWM and MLC responses were much more sensitive to inhibition followed by, in order of decreasing inhibition, Con A, PHA, ionomycin alone, and PMA/ionomycin.	Tetradecanoylphorbol Acetate	251-254	beta-2-microglobulin	Homo sapiens	47-54
11537644-11	1992	These observations demonstrate that gravity affects specific components in the EGF-induced signal transduction circuitry, in particular the protein kinase C pathway which is common to EGF and TPA activated intracellular signalling.	Tetradecanoylphorbol Acetate	192-195	epidermal growth factor	Homo sapiens	79-82
7795236-9	1995	Cyclin D1 expression alone was not sufficient to induce polyploidy, but in conjunction with PMA-induced differentiation, polyploidization was slightly enhanced.	Tetradecanoylphorbol Acetate	92-95	cyclin D1	Homo sapiens	0-9
2001419-2	1991	12-O-Tetradecanoyl phorbol 13-acetate (TPA) doubled ionomycin-induced PLA2 activity, assessed by [3H]arachidonate release.	Tetradecanoylphorbol Acetate	0-37	phospholipase A2 group IB	Rattus norvegicus	70-74
2001419-2	1991	12-O-Tetradecanoyl phorbol 13-acetate (TPA) doubled ionomycin-induced PLA2 activity, assessed by [3H]arachidonate release.	Tetradecanoylphorbol Acetate	39-42	phospholipase A2 group IB	Rattus norvegicus	70-74
7606799-4	1995	Phorbol ester (PMA), a direct activator of PKC, provoked LHRH production and cell surface expression of CD69 and IL-2R molecules by T cells, but not IL-2 synthesis.	Tetradecanoylphorbol Acetate	15-18	gonadotropin releasing hormone 1	Homo sapiens	57-61
1330924-6	1992	Priming concentrations of PAF also augmented the adherence of neutrophils to endothelium in the presence of the soluble agonists A23187, phorbol myristate acetate, and FMLP.	Tetradecanoylphorbol Acetate	137-162	PCNA clamp associated factor	Homo sapiens	26-29
7606799-4	1995	Phorbol ester (PMA), a direct activator of PKC, provoked LHRH production and cell surface expression of CD69 and IL-2R molecules by T cells, but not IL-2 synthesis.	Tetradecanoylphorbol Acetate	15-18	CD69 molecule	Homo sapiens	104-108
7606799-4	1995	Phorbol ester (PMA), a direct activator of PKC, provoked LHRH production and cell surface expression of CD69 and IL-2R molecules by T cells, but not IL-2 synthesis.	Tetradecanoylphorbol Acetate	15-18	interleukin 2 receptor subunit alpha	Homo sapiens	113-118
1334710-3	1992	By combining SAC, or the phorbol ester TPA, with IL-2 and the conditioned medium of a T-cell hybridoma (BSF-MP6), we could strongly enhance the Trx expression.	Tetradecanoylphorbol Acetate	39-42	thioredoxin	Homo sapiens	144-147
1846746-3	1991	4 beta-phorbol 12-myristate 13-acetate (PMA) and 1,2-dioctanoyl-sn-glycerol, which directly activate PKC, stimulated the synthesis of PAF.	Tetradecanoylphorbol Acetate	0-38	PCNA clamp associated factor	Homo sapiens	134-137
7545455-12	1995	Phorbol ester (TPA) enhanced the IL-3R mRNA expression in KMT2.	Tetradecanoylphorbol Acetate	15-18	interleukin 3 receptor subunit alpha	Homo sapiens	33-38
1725105-0	1991	The main serum protease inhibitors; alpha-1-proteinase inhibitor and alpha-2-macroglobulin inhibit H2O2 release from human polymorphonuclear leukocytes stimulated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	168-193	alpha-2-macroglobulin	Homo sapiens	69-90
1406654-4	1992	We have found that overexpression of transforming growth factor alpha (TGF-alpha) in the basal epidermal layer of transgenic mice yielded papillomas directly upon wounding or 12-O-tetradecanoylphorbol-13-acetate treatment without the need for an initiator.	Tetradecanoylphorbol Acetate	175-211	transforming growth factor alpha	Mus musculus	37-69
1406654-4	1992	We have found that overexpression of transforming growth factor alpha (TGF-alpha) in the basal epidermal layer of transgenic mice yielded papillomas directly upon wounding or 12-O-tetradecanoylphorbol-13-acetate treatment without the need for an initiator.	Tetradecanoylphorbol Acetate	175-211	transforming growth factor alpha	Mus musculus	71-80
7791790-6	1995	Cotransfection experiments revealed that both hGATA-4 and phorbol-12-myristate-13-acetate (PMA)-A23187 stimulation are necessary for IL-5 promoter activation.	Tetradecanoylphorbol Acetate	58-89	interleukin 5	Homo sapiens	133-137
1280905-4	1992	The activation of protein kinase C was attained with the phorbol esther 12-O-tetradecanoylphorbol-13-acetate, protein kinase A was activated by increasing cAMP levels with forskolin or rolipram, and the phosphatase activity was inhibited with okadaic acid (OA), which inhibits phosphatases type 1 and 2A.	Tetradecanoylphorbol Acetate	72-108	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	110-126
1850068-3	1991	Cells exposed to the tumor promoting phorbol esters (phorbol 12-myristate 13-acetate, phorbol 12,13-dibutyrate or 4-beta-phorbol 12,13-didecanoate) for 12 h differentially activated PNMT mRNA and ProEnk A mRNA expression.	Tetradecanoylphorbol Acetate	53-84	proenkephalin	Bos taurus	196-204
1892733-2	1991	Protein kinase C activators PMA 4-phorbol 12-myristate 13-acetate and DiC8 (1,2-dioctanoyl-sn-glycerol) also increased arachidonic acid release, but the time course observed with PMA was different from that of IL-1.	Tetradecanoylphorbol Acetate	28-31	interleukin 1 alpha	Homo sapiens	210-214
1892733-3	1991	When cultures were treated with PMA for 16-24 h to down regulate protein kinase C, the ability of IL-1 to increase arachidonic acid release persisted to the same extent as in nontreated cultures.	Tetradecanoylphorbol Acetate	32-35	interleukin 1 alpha	Homo sapiens	98-102
7791790-6	1995	Cotransfection experiments revealed that both hGATA-4 and phorbol-12-myristate-13-acetate (PMA)-A23187 stimulation are necessary for IL-5 promoter activation.	Tetradecanoylphorbol Acetate	91-94	interleukin 5	Homo sapiens	133-137
2007096-3	1991	In this report, we show that transient expression of the PKC gamma isoenzyme can trans-activate a murine VL30 enhancer element in a pattern similar to that of the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	192-228	protein kinase C, gamma	Mus musculus	57-66
32370452-8	1992	Phorbol 12-myristate 13-acetate (PMA) stimulated NCAM mRNA expression in 5 of 6 tumors.	Tetradecanoylphorbol Acetate	0-31	neural cell adhesion molecule 1	Homo sapiens	49-53
7775485-8	1995	In addition, sequences upstream of the inducible start site, which contains a TPA-responsive element, mediates TPA inducibility through AP1 (or an AP1-like) transcription factor.	Tetradecanoylphorbol Acetate	78-81	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-139
32370452-8	1992	Phorbol 12-myristate 13-acetate (PMA) stimulated NCAM mRNA expression in 5 of 6 tumors.	Tetradecanoylphorbol Acetate	33-36	neural cell adhesion molecule 1	Homo sapiens	49-53
1723284-2	1991	Stably transfected lymphoid clones expressing antisense RNA were tested for their ability to synthesize GM-CSF in response to stimulation with phorbol 12-myristate 13-acetate (TPA) and ionomycin.	Tetradecanoylphorbol Acetate	143-174	colony stimulating factor 2	Homo sapiens	104-110
1723284-2	1991	Stably transfected lymphoid clones expressing antisense RNA were tested for their ability to synthesize GM-CSF in response to stimulation with phorbol 12-myristate 13-acetate (TPA) and ionomycin.	Tetradecanoylphorbol Acetate	176-179	colony stimulating factor 2	Homo sapiens	104-110
7775485-8	1995	In addition, sequences upstream of the inducible start site, which contains a TPA-responsive element, mediates TPA inducibility through AP1 (or an AP1-like) transcription factor.	Tetradecanoylphorbol Acetate	78-81	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	147-155
7775485-8	1995	In addition, sequences upstream of the inducible start site, which contains a TPA-responsive element, mediates TPA inducibility through AP1 (or an AP1-like) transcription factor.	Tetradecanoylphorbol Acetate	111-114	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-139
1705636-5	1991	G-CSF induced TPA- and FMLP-stimulated NBT reduction in the presence of 100 nM RA, but GM-CSF induced only TPA-stimulated NBT reduction.	Tetradecanoylphorbol Acetate	14-17	colony stimulating factor 3	Homo sapiens	0-5
1331038-6	1992	Treatment of quiescent C2 cells with a tumor promoter, 12-O-tetradecanoylphorbol 13-acetate, transiently induced c-jun and c-fos mRNAs, and temporarily deinduced myoD and myogenin mRNAs just after the expression of the protooncogenes.	Tetradecanoylphorbol Acetate	55-91	FBJ osteosarcoma oncogene	Mus musculus	123-128
7775485-8	1995	In addition, sequences upstream of the inducible start site, which contains a TPA-responsive element, mediates TPA inducibility through AP1 (or an AP1-like) transcription factor.	Tetradecanoylphorbol Acetate	111-114	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	147-155
1331038-6	1992	Treatment of quiescent C2 cells with a tumor promoter, 12-O-tetradecanoylphorbol 13-acetate, transiently induced c-jun and c-fos mRNAs, and temporarily deinduced myoD and myogenin mRNAs just after the expression of the protooncogenes.	Tetradecanoylphorbol Acetate	55-91	myogenic differentiation 1	Mus musculus	162-166
1331038-6	1992	Treatment of quiescent C2 cells with a tumor promoter, 12-O-tetradecanoylphorbol 13-acetate, transiently induced c-jun and c-fos mRNAs, and temporarily deinduced myoD and myogenin mRNAs just after the expression of the protooncogenes.	Tetradecanoylphorbol Acetate	55-91	myogenin	Mus musculus	171-179
1705636-5	1991	G-CSF induced TPA- and FMLP-stimulated NBT reduction in the presence of 100 nM RA, but GM-CSF induced only TPA-stimulated NBT reduction.	Tetradecanoylphorbol Acetate	107-110	colony stimulating factor 2	Homo sapiens	87-93
7645378-6	1995	However, the addition of phorbol 12-myristate 13-acetate (PMA) caused the significant recovery of CD25 expression.	Tetradecanoylphorbol Acetate	25-56	interleukin 2 receptor subunit alpha	Homo sapiens	98-102
2009135-6	1991	A single topical application of TPA or chrysarobin induced elevated levels of transforming growth factor-alpha (TGF-alpha) mRNA at 6 h or 15-24 h, respectively.	Tetradecanoylphorbol Acetate	32-35	transforming growth factor alpha	Mus musculus	78-110
2009135-6	1991	A single topical application of TPA or chrysarobin induced elevated levels of transforming growth factor-alpha (TGF-alpha) mRNA at 6 h or 15-24 h, respectively.	Tetradecanoylphorbol Acetate	32-35	transforming growth factor alpha	Mus musculus	112-121
1323817-5	1992	Transfection of the smg p21 cDNAs inhibited the activated ras p21-, PDGF- or TPA-stimulated c-fos-luciferase expression, but did not inhibit the activated c-raf-1 kinase- or Bt2cAMP-stimulated reaction.	Tetradecanoylphorbol Acetate	77-80	FBJ osteosarcoma oncogene	Mus musculus	92-97
1643643-4	1992	Dose-response studies revealed that the most effective TPA concentration for stimulation of DNA synthesis and growth of melanocytes (10 ng/ml TPA) also supported a relatively high level of PKC enzyme activity, increased membrane association of the PKC alpha and PKC epsilon isoforms, and led to a high level of phosphorylation of a major PKC substrate, the myristoylated alanine-rich C kinase substrate (MARCKS) protein.	Tetradecanoylphorbol Acetate	55-58	protein kinase C epsilon	Homo sapiens	262-273
1643643-4	1992	Dose-response studies revealed that the most effective TPA concentration for stimulation of DNA synthesis and growth of melanocytes (10 ng/ml TPA) also supported a relatively high level of PKC enzyme activity, increased membrane association of the PKC alpha and PKC epsilon isoforms, and led to a high level of phosphorylation of a major PKC substrate, the myristoylated alanine-rich C kinase substrate (MARCKS) protein.	Tetradecanoylphorbol Acetate	142-145	protein kinase C epsilon	Homo sapiens	262-273
1643643-6	1992	Furthermore, treatment of melanocytes with 100 ng/ml TPA for 48 h resulted in a marked decrease in total PKC enzyme activity and the loss of expression of the PKC alpha and PKC epsilon isoforms in both the cytosol and membrane-bound fractions, when examined by immunoblot analysis.	Tetradecanoylphorbol Acetate	53-56	protein kinase C epsilon	Homo sapiens	173-184
2009135-7	1991	Elevated levels of a TGF-alpha precursor (21 kDa) were subsequently observed in cytosol and membrane preparations after single and multiple applications of TPA or chrysarobin.	Tetradecanoylphorbol Acetate	156-159	transforming growth factor alpha	Mus musculus	21-30
7645378-6	1995	However, the addition of phorbol 12-myristate 13-acetate (PMA) caused the significant recovery of CD25 expression.	Tetradecanoylphorbol Acetate	58-61	interleukin 2 receptor subunit alpha	Homo sapiens	98-102
7537734-6	1995	When wild type and S180A/S204A double mutant RPTP alpha S were transiently expressed in 293 human embryonic kidney cells, TPA stimulated phosphorylation of wild type but not of double mutant RPTP alpha.	Tetradecanoylphorbol Acetate	122-125	protein tyrosine phosphatase receptor type A	Homo sapiens	45-55
1701670-2	1990	Most circulating human neutrophils express the Leu-8 molecule, and activation of neutrophils with phorbol myristate acetate causes a rapid decline in Leu-8 membrane fluorescence staining within 15 minutes.	Tetradecanoylphorbol Acetate	98-123	selectin L	Homo sapiens	47-52
1701670-2	1990	Most circulating human neutrophils express the Leu-8 molecule, and activation of neutrophils with phorbol myristate acetate causes a rapid decline in Leu-8 membrane fluorescence staining within 15 minutes.	Tetradecanoylphorbol Acetate	98-123	selectin L	Homo sapiens	150-155
1386358-9	1992	Immunoprecipitation of surface-labeled proteins by an anti-fibronectin receptor (integrin) antibody showed that PMA-treated cultures had more fibronectin receptor protein than untreated cultures 6 days post-induction.	Tetradecanoylphorbol Acetate	112-115	fibronectin 1	Mus musculus	59-70
1386358-9	1992	Immunoprecipitation of surface-labeled proteins by an anti-fibronectin receptor (integrin) antibody showed that PMA-treated cultures had more fibronectin receptor protein than untreated cultures 6 days post-induction.	Tetradecanoylphorbol Acetate	112-115	fibronectin 1	Mus musculus	142-153
1386358-10	1992	As a result, cultures of committed MELC treated with PMA remained attached to fibronectin-coated plates, whereas non-PMA-treated cells were released into the culture medium.	Tetradecanoylphorbol Acetate	53-56	fibronectin 1	Mus musculus	78-89
7737978-8	1995	The TPA-induced decrease in 125I-MGSA binding is accompanied by enhanced degradation of the IL-8RB, as indicated by Western blot analysis and pulse-chase experiments, suggesting a potential role for PKC as a negative regulator of the IL-8RB.	Tetradecanoylphorbol Acetate	4-7	C-X-C motif chemokine receptor 2	Homo sapiens	92-98
2123448-7	1990	Chronic preincubation with the phorbol ester phorbol 12-myristate 13-acetate interfered with the induction of c-fos by GH, suggesting that diacylglycerol and protein kinase C are involved in this effect of GH.	Tetradecanoylphorbol Acetate	45-76	FBJ osteosarcoma oncogene	Mus musculus	110-115
7737978-8	1995	The TPA-induced decrease in 125I-MGSA binding is accompanied by enhanced degradation of the IL-8RB, as indicated by Western blot analysis and pulse-chase experiments, suggesting a potential role for PKC as a negative regulator of the IL-8RB.	Tetradecanoylphorbol Acetate	4-7	C-X-C motif chemokine receptor 2	Homo sapiens	234-240
7542077-2	1995	Stimuli delivered by the combination of phorbol ester (PMA) and CA2+ ionophore (ionomycin) induced marked IL-5 production by PBMCs obtained from atopic as well as nonatopic asthmatics.	Tetradecanoylphorbol Acetate	55-58	interleukin 5	Homo sapiens	106-110
1700789-12	1990	Phorbol myristate acetate also stimulated hexose transport as well as expression of the GLUT-1 gene and several immediate-early genes in quiescent 3T3-L1 cells.	Tetradecanoylphorbol Acetate	0-25	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	88-94
1390335-0	1992	12-O-tetradecanoylphorbol-13-acetate induces transient cell cycle arrest in G1 and G2 in metastatic melanoma cells: inhibition of phosphorylation of p34cdc2.	Tetradecanoylphorbol Acetate	0-36	cyclin dependent kinase 1	Homo sapiens	149-156
1390335-4	1992	In addition, TPA induced a pronounced morphological change, which peaked by 1 h and gradually subsided over 24 h. In populations of cells synchronized in G1 using lovastatin, (a) addition of TPA blocked the onset of DNA synthesis up to the end of G1; (b) the lag between addition of the drug and onset of DNA synthesis was less than 30 min; and (c) addition of TPA at the end of G1 prevented the increased phosphorylation of p34cdc2, as determined by immunoprecipitation.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase 1	Homo sapiens	425-432
1390335-4	1992	In addition, TPA induced a pronounced morphological change, which peaked by 1 h and gradually subsided over 24 h. In populations of cells synchronized in G1 using lovastatin, (a) addition of TPA blocked the onset of DNA synthesis up to the end of G1; (b) the lag between addition of the drug and onset of DNA synthesis was less than 30 min; and (c) addition of TPA at the end of G1 prevented the increased phosphorylation of p34cdc2, as determined by immunoprecipitation.	Tetradecanoylphorbol Acetate	191-194	cyclin dependent kinase 1	Homo sapiens	425-432
1390335-4	1992	In addition, TPA induced a pronounced morphological change, which peaked by 1 h and gradually subsided over 24 h. In populations of cells synchronized in G1 using lovastatin, (a) addition of TPA blocked the onset of DNA synthesis up to the end of G1; (b) the lag between addition of the drug and onset of DNA synthesis was less than 30 min; and (c) addition of TPA at the end of G1 prevented the increased phosphorylation of p34cdc2, as determined by immunoprecipitation.	Tetradecanoylphorbol Acetate	191-194	cyclin dependent kinase 1	Homo sapiens	425-432
2244911-8	1990	Prolonged exposure of HUVEC to phorbol myristate acetate down-regulated PKC activity and inhibited subsequent ICAM-1 up-regulation by this agent and by IL-1.	Tetradecanoylphorbol Acetate	31-56	interleukin 1 alpha	Homo sapiens	152-156
7722494-4	1995	This potentiation appears to involve protein kinase C (PKC) because alpha 1-adrenergic activation is known to translocate PKC and the PACAP-stimulated cyclic AMP accumulation was potentiated ninefold by a PKC activator, 4 beta-phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	222-258	adenylate cyclase activating polypeptide 1	Rattus norvegicus	134-139
7722494-4	1995	This potentiation appears to involve protein kinase C (PKC) because alpha 1-adrenergic activation is known to translocate PKC and the PACAP-stimulated cyclic AMP accumulation was potentiated ninefold by a PKC activator, 4 beta-phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	260-263	adenylate cyclase activating polypeptide 1	Rattus norvegicus	134-139
2246237-1	1990	A 10-50-fold, biphasic increase in the rate of 32Pi labeling of eIF-4E was closely correlated with the induction of protein and glycoprotein biosynthesis when resting murine splenic B lymphocytes (B cells) were activated by bacterial lipopolysaccharide or the combination of phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	275-306	eukaryotic translation initiation factor 4E	Mus musculus	64-70
1365641-12	1992	In contrast, retinoic acid strongly increased phorbol myristate acetate-induced MCP-1 expression and potentiated the effects of IL-1 and LPS.	Tetradecanoylphorbol Acetate	46-71	C-C motif chemokine ligand 2	Homo sapiens	80-85
7722494-5	1995	Phenylephrine and PMA also potentiated the PACAP-stimulated MT accumulation.	Tetradecanoylphorbol Acetate	18-21	adenylate cyclase activating polypeptide 1	Rattus norvegicus	43-48
7624029-4	1995	Both PACAP 27 and PACAP 38 are able to stimulate proliferation of adult rat chromaffin cells in vitro, either alone or in conjunction with PMA, an activator of protein kinase C. BrdU-labelled nuclei are observed in both epinephrine and norepinephrine cells, and proliferation of both cell types is stimulated by the same concentrations of PACAP that elicit secretion of catecholamines.	Tetradecanoylphorbol Acetate	139-142	adenylate cyclase activating polypeptide 1	Rattus norvegicus	18-23
1379255-4	1992	Phorbol 12-myristate 13-acetate (PMA) stimulated IGFBP-1 production in a time- and dose-dependent manner, with maximal stimulation occurring at 10-100 nmol/L.	Tetradecanoylphorbol Acetate	0-31	insulin like growth factor binding protein 1	Homo sapiens	49-56
1379255-4	1992	Phorbol 12-myristate 13-acetate (PMA) stimulated IGFBP-1 production in a time- and dose-dependent manner, with maximal stimulation occurring at 10-100 nmol/L.	Tetradecanoylphorbol Acetate	33-36	insulin like growth factor binding protein 1	Homo sapiens	49-56
2246268-7	1990	In the cytosol of phorbol myristate acetate-activated neutrophils eight distinct p47 phosphoproteins were present.	Tetradecanoylphorbol Acetate	18-43	pleckstrin	Homo sapiens	81-84
2213017-4	1990	The protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulates the synthesis of both uPA and PAI-1, resulting in a final increase in the plasmin-generating capacity of neuronal cell cultures.	Tetradecanoylphorbol Acetate	37-73	serpin family E member 1	Homo sapiens	121-126
2213017-4	1990	The protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulates the synthesis of both uPA and PAI-1, resulting in a final increase in the plasmin-generating capacity of neuronal cell cultures.	Tetradecanoylphorbol Acetate	75-78	serpin family E member 1	Homo sapiens	121-126
1511786-6	1992	The PKC agonist PMA (phorbol 12-myristate 13-acetate, 10(-6) M) produced a small rise in basal [Ca2+]i and abolished the GnRH calcium response.	Tetradecanoylphorbol Acetate	16-19	gonadotropin releasing hormone 1	Mus musculus	121-125
7624029-4	1995	Both PACAP 27 and PACAP 38 are able to stimulate proliferation of adult rat chromaffin cells in vitro, either alone or in conjunction with PMA, an activator of protein kinase C. BrdU-labelled nuclei are observed in both epinephrine and norepinephrine cells, and proliferation of both cell types is stimulated by the same concentrations of PACAP that elicit secretion of catecholamines.	Tetradecanoylphorbol Acetate	139-142	adenylate cyclase activating polypeptide 1	Rattus norvegicus	18-23
1511786-6	1992	The PKC agonist PMA (phorbol 12-myristate 13-acetate, 10(-6) M) produced a small rise in basal [Ca2+]i and abolished the GnRH calcium response.	Tetradecanoylphorbol Acetate	21-52	gonadotropin releasing hormone 1	Mus musculus	121-125
2267130-2	1990	Op18 is phosphorylated upon treatment of lymphoid cells with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	61-86	stathmin 1	Homo sapiens	0-4
7697853-6	1995	These increases in ecto-5"-nucleotidase activity were inhibited by GF109203X, an inhibitor of protein kinase C, and mimicked by phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C. The increase in ecto-5"-nucleotidase was not prevented by cycloheximide.	Tetradecanoylphorbol Acetate	128-159	5' nucleotidase, ecto	Rattus norvegicus	19-39
2281080-4	1990	The phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate (TPA), an activator of protein kinase C, also increased both S6 phosphorylation in intact acini and soluble S6 kinase activity.	Tetradecanoylphorbol Acetate	18-55	ribosomal protein S6 kinase B1	Rattus norvegicus	164-173
2281080-4	1990	The phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate (TPA), an activator of protein kinase C, also increased both S6 phosphorylation in intact acini and soluble S6 kinase activity.	Tetradecanoylphorbol Acetate	57-60	ribosomal protein S6 kinase B1	Rattus norvegicus	164-173
7697853-6	1995	These increases in ecto-5"-nucleotidase activity were inhibited by GF109203X, an inhibitor of protein kinase C, and mimicked by phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C. The increase in ecto-5"-nucleotidase was not prevented by cycloheximide.	Tetradecanoylphorbol Acetate	128-159	5' nucleotidase, ecto	Rattus norvegicus	217-237
1637804-5	1992	Tropoelastin mRNA levels decreased greater than 10-fold in response to TPA, and this downregulation was paralleled by a decline in the secretion of tropoelastin protein into the culture medium.	Tetradecanoylphorbol Acetate	71-74	elastin	Bos taurus	0-12
7697853-6	1995	These increases in ecto-5"-nucleotidase activity were inhibited by GF109203X, an inhibitor of protein kinase C, and mimicked by phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C. The increase in ecto-5"-nucleotidase was not prevented by cycloheximide.	Tetradecanoylphorbol Acetate	161-164	5' nucleotidase, ecto	Rattus norvegicus	19-39
1637804-7	1992	As indicated by actinomycin D experiments, the half-life of tropoelastin mRNA in control cells was about 20 h, but exposure to TPA resulted in an accelerated decay of the tropoelastin transcript (t1/2 = 2.2 h).	Tetradecanoylphorbol Acetate	127-130	elastin	Bos taurus	171-183
1699760-1	1990	This work shows that tumor promoter agents (TPA) induce the post-translational modification of the human lymphocyte surface CD5 antigen (Tp67) in several cellular types.	Tetradecanoylphorbol Acetate	44-47	CD5 molecule	Homo sapiens	124-127
7697853-6	1995	These increases in ecto-5"-nucleotidase activity were inhibited by GF109203X, an inhibitor of protein kinase C, and mimicked by phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C. The increase in ecto-5"-nucleotidase was not prevented by cycloheximide.	Tetradecanoylphorbol Acetate	161-164	5' nucleotidase, ecto	Rattus norvegicus	217-237
1699760-5	1990	Phosphatase digestion of CD5 immunoprecipitates reverted the TPA-mediated mobility changes showing its dependence on phosphorylation.	Tetradecanoylphorbol Acetate	61-64	CD5 molecule	Homo sapiens	25-28
7697853-7	1995	When ecto-5"-nucleotidase activity increased, adenosine release was augmented in methoxamine- and PMA-treated cardiomyocytes (1299 +/- 252% and 1372 +/- 149%, respectively) compared with the untreated group (578 +/- 26%).	Tetradecanoylphorbol Acetate	98-101	5' nucleotidase, ecto	Rattus norvegicus	5-25
1699760-6	1990	Neuraminidase digestion of intact cells revealed that the target of the TPA effects are surface-expressed CD5 molecules.	Tetradecanoylphorbol Acetate	72-75	CD5 molecule	Homo sapiens	106-109
1636737-7	1992	Phorbol 12-myristate 13-acetate was also found to activate S6 kinase, and 24 h of pretreatment to deplete protein kinase C inhibited subsequent S6 kinase activation by a high concentration (10(-6) M) of angiotensin II.	Tetradecanoylphorbol Acetate	0-31	ribosomal protein S6 kinase B1	Rattus norvegicus	59-68
1699760-7	1990	In conclusion, we suggest that the heterogeneity in the electrophoretic mobility induced by TPA could reflect some structural and/or functional differences within CD5 molecules.	Tetradecanoylphorbol Acetate	92-95	CD5 molecule	Homo sapiens	163-166
1636737-7	1992	Phorbol 12-myristate 13-acetate was also found to activate S6 kinase, and 24 h of pretreatment to deplete protein kinase C inhibited subsequent S6 kinase activation by a high concentration (10(-6) M) of angiotensin II.	Tetradecanoylphorbol Acetate	0-31	ribosomal protein S6 kinase B1	Rattus norvegicus	144-153
7718627-7	1995	Down-regulation of protein kinase C (PKC) activity by TPA pretreatment repressed the bFGF induction of TIS1 but had little effect on the bFGF-stimulated expression of TIS8.	Tetradecanoylphorbol Acetate	54-57	fibroblast growth factor 2	Mus musculus	85-89
1698561-0	1990	Quantitative analysis of CD5 antigen modulation by 12-O-tetradecanoylphorbol-13-acetate in T-lymphoblastic leukemia cells: individual response patterns and their relationships with both maturation and protein kinase C content.	Tetradecanoylphorbol Acetate	51-87	CD5 molecule	Homo sapiens	25-28
1698561-3	1990	CD5 expression was found 6- to 17-fold increased by TPA in a dose-dependent manner on phenotypically mature T-cells (Jurkat, JM, and T-CLL) while T-cells from earlier stages of differentiation (CEM III, CEM 95, and CEM 44) were found unresponsive.	Tetradecanoylphorbol Acetate	52-55	CD5 molecule	Homo sapiens	0-3
7717978-5	1995	The tumour promoter and protein kinase C agonist, phorbol 12-myristate 13-acetate (PMA), also activated Raf-1, MEK-1, and MAP kinase in Ramos cells, but did not induce tyrosine phosphorylation of Shc or Shc/Grb2 association.	Tetradecanoylphorbol Acetate	50-81	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	104-109
1698561-4	1990	CD5 upregulation on TPA-sensitive JM cells appears correlated with inhibition of cell growth, blockage in G1 phase, and phenotypic maturation (downregulation of CD7 and CD1 antigens) and seemed to be related to PKC activation since DiC8 (a PKC activator) mimicked this TPA effect and H7 (a PKC inhibitor) partially reduced it.	Tetradecanoylphorbol Acetate	20-23	CD5 molecule	Homo sapiens	0-3
7717978-5	1995	The tumour promoter and protein kinase C agonist, phorbol 12-myristate 13-acetate (PMA), also activated Raf-1, MEK-1, and MAP kinase in Ramos cells, but did not induce tyrosine phosphorylation of Shc or Shc/Grb2 association.	Tetradecanoylphorbol Acetate	83-86	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	104-109
7532590-5	1995	However, a strong phosphorylation of the CD18-chain by preexposure to phorbol myristate acetate (PMA) coincided with an abolishment of both the beta 2-integrin-induced Ca2+ signal and the protein tyrosine phosphorylations.	Tetradecanoylphorbol Acetate	97-100	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	144-150
7757328-12	1995	In vitro after stimulation with TPA or IFN-gamma, the mivit/mivit epidermal cells expressed significantly lesser amounts of ICAM-1 than the C57BL/6 epidermal cells.	Tetradecanoylphorbol Acetate	32-35	intercellular adhesion molecule 1	Mus musculus	124-130
2169338-5	1990	Specifically, TPA increased interstitial collagenase mRNA levels in each cell line and decreased type IV collagenase mRNA levels in control fibroblasts and the tumorigenic cell lines, HT-1080 and A2058.	Tetradecanoylphorbol Acetate	14-17	matrix metallopeptidase 1	Homo sapiens	28-52
7829884-6	1995	Stimulation of microvascular endothelial cells with basic fibroblast growth factor or phorbol 12-myristate 13-acetate, agents previously shown to induce endothelial cell migration in vitro, resulted in a marked decrease in cell-surface expression of the beta 4 integrin chain, associated with a decrease in beta 4 mRNA.	Tetradecanoylphorbol Acetate	86-117	tubulin beta 3 class III	Homo sapiens	254-260
1976463-2	1990	Unlike resting CD4+ normal T lymphocytes that can be activated only by a two-signal stimulation, T-CLL cells proliferated and released IL-2 in response to a pair of anti-CD2 monoclonal antibodies (MoAbs) or concanavalin A (Con A) in the absence of both accessory cells (AC) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	278-303	CD2 molecule	Homo sapiens	170-173
2283681-6	1990	Addition of the PKC inhibitor staurosporine (1 and 10 nM) completely inhibited the action of TPA on EGF-induced [Ca2+]i changes.	Tetradecanoylphorbol Acetate	93-96	epidermal growth factor	Homo sapiens	100-103
2283681-8	1990	Down-regulation of PKC by overnight incubation with 0.1 or 1 microM TPA produced the converse effect, namely prolonged Ca2+ entry following stimulation with EGF or TGF-alpha.	Tetradecanoylphorbol Acetate	68-71	epidermal growth factor	Homo sapiens	157-160
2283681-13	1990	A431 cells treated with higher concentrations of TPA (5 x 10(-8) M) inhibited not only Ca2+ entry but also Ca2+ release due to EGF/TGF-alpha but had no effect on bradykinin-mediated Ca2+ release, suggesting differences in the regulation of the intracellular stores responsive to these two classes of agonists.	Tetradecanoylphorbol Acetate	49-52	epidermal growth factor	Homo sapiens	127-130
7829884-6	1995	Stimulation of microvascular endothelial cells with basic fibroblast growth factor or phorbol 12-myristate 13-acetate, agents previously shown to induce endothelial cell migration in vitro, resulted in a marked decrease in cell-surface expression of the beta 4 integrin chain, associated with a decrease in beta 4 mRNA.	Tetradecanoylphorbol Acetate	86-117	tubulin beta 3 class III	Homo sapiens	307-313
7835696-5	1995	Electrophoretic mobility shift assays and mutational analyses suggest that the promoter site is bound by nuclear protein complexes containing cAMP-independent members of the ATF/CREB family of proteins and c-Jun, and are functionally distinct from the AP1-related TPA-response element (TRE) binding activity.	Tetradecanoylphorbol Acetate	264-267	glial cell line derived neurotrophic factor	Mus musculus	174-177
2204815-3	1990	Each site in the IL-2 enhancer that bound Oct-1 in vitro was also required to achieve a maximal transcriptional response to TPA plus PHA in vivo.	Tetradecanoylphorbol Acetate	124-127	POU class 2 homeobox 1	Homo sapiens	42-47
7835696-5	1995	Electrophoretic mobility shift assays and mutational analyses suggest that the promoter site is bound by nuclear protein complexes containing cAMP-independent members of the ATF/CREB family of proteins and c-Jun, and are functionally distinct from the AP1-related TPA-response element (TRE) binding activity.	Tetradecanoylphorbol Acetate	264-267	jun proto-oncogene	Mus musculus	206-211
7826379-6	1995	The autophosphorylation of PKC delta with GTP does not differ from that with ATP regarding its activation by TPA or bryostatin, its inhibition by staurosporine, the type of phosphorylated amino acids (serine and threonine) and the mode of reaction (intrapeptide reaction).	Tetradecanoylphorbol Acetate	109-112	protein kinase C delta	Homo sapiens	27-36
2401358-6	1990	TPA-treatment of these cels is accompanied by a rapid, selective and complete loss of lipid-dependent activity of the cytosol, thus benefiting co-migrating lipid independent activity, with no membrane fraction recovery or PKM formation.	Tetradecanoylphorbol Acetate	0-3	pyruvate kinase M1/2	Homo sapiens	222-225
7818548-1	1995	In order to examine whether PKC is involved in the activation of NF-kappa B by TPA, we overexpressed a variety of PKC isozymes in rat 3Y1 fibroblasts and monitored the expression of the co-transfected reporter NF-kappa B gene.	Tetradecanoylphorbol Acetate	79-82	protein kinase C, delta	Rattus norvegicus	28-31
1982981-3	1990	GF induced the lymphocyte proliferation in combination with phorbol ester (PMA) or anti-CD2 monoclonal antibodies (mAb) with PMA.	Tetradecanoylphorbol Acetate	125-128	CD2 molecule	Homo sapiens	88-91
7818548-2	1995	In contrast to TPA response element (TRE), where overexpression of a variety of PKC isozymes results in enhanced activation by TPA, activation of NF-kappa B by TPA is not enhanced by overexpression of PKC isozymes such as cPKC alpha, nPKC delta, or nPKC theta.	Tetradecanoylphorbol Acetate	15-18	protein kinase C, delta	Rattus norvegicus	80-83
1696526-2	1990	We found that CD1+ cells expressed high levels of CD25 antigen upon triggering with specific monoclonal antibodies (mAbs) (anti-CD3, anti-CD2, anti-CD28) in association with low doses of Phorbol-13-myristate-12-acetate (PMA).	Tetradecanoylphorbol Acetate	220-223	CD2 molecule	Homo sapiens	50-53
7843222-8	1995	PMA-induced PKC activation for a 1-h period resulted in a translocation of PKC delta from resting cytoplasmic/nuclear staining to a cytoplasmic aggregate.	Tetradecanoylphorbol Acetate	0-3	protein kinase C delta	Homo sapiens	75-84
2401043-5	1990	In contrast, TPA caused a rapid inhibition of EGF binding, primarily due to a loss of high-affinity receptors.	Tetradecanoylphorbol Acetate	13-16	epidermal growth factor	Mus musculus	46-49
7818763-6	1995	Repeated applications of TPA resulted in stationary hyperplasia and downregulation of PGHS-2 expression and prostaglandin levels, suggesting that the epidermis had adapted to the TPA stimulus.	Tetradecanoylphorbol Acetate	25-28	prostaglandin-endoperoxide synthase 2	Mus musculus	86-92
2401043-6	1990	The mechanism by which chrysarobin inhibited the binding of EGF to its receptor involved neither direct activation nor membrane translocation of epidermal protein kinase C, whereas the rapid decrease in EGF binding induced by TPA was consistent with its ability to activate protein kinase C. Structure-activity relationships for EGF binding inhibition by anthrones revealed that inhibition was inversely proportional to chain length at the C10-position, which correlated closely with oxidation rate and skin tumor-promoting activity.	Tetradecanoylphorbol Acetate	226-229	epidermal growth factor	Mus musculus	203-206
2401043-6	1990	The mechanism by which chrysarobin inhibited the binding of EGF to its receptor involved neither direct activation nor membrane translocation of epidermal protein kinase C, whereas the rapid decrease in EGF binding induced by TPA was consistent with its ability to activate protein kinase C. Structure-activity relationships for EGF binding inhibition by anthrones revealed that inhibition was inversely proportional to chain length at the C10-position, which correlated closely with oxidation rate and skin tumor-promoting activity.	Tetradecanoylphorbol Acetate	226-229	epidermal growth factor	Mus musculus	203-206
7799956-10	1995	Phorbol 12-myristate 13-acetate pretreatment led to the sustained activation of the Raf-1 kinase but not that of MEK and MAPK.	Tetradecanoylphorbol Acetate	0-31	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	84-89
7828883-7	1994	This region is highly conserved in the TIS11 family of immediate early genes, which in mammalian cells are rapidly and transiently induced in response to 12-O-tetradecanoyl phorbol-13-acetate (TPA) and to mitogens such as epidermal growth factor and fibroblast growth factor.	Tetradecanoylphorbol Acetate	154-191	ZFP36 ring finger protein	Homo sapiens	39-44
2201557-7	1990	In contrast, after 2 h of exposure to 8 nM PMA, a statistically significant increase (p less than 0.001) in c-myc and beta-actin mRNA expression was observed, whereas FV mRNA expression appeared to be unchanged (p = 0.207).	Tetradecanoylphorbol Acetate	43-46	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	108-113
7828883-7	1994	This region is highly conserved in the TIS11 family of immediate early genes, which in mammalian cells are rapidly and transiently induced in response to 12-O-tetradecanoyl phorbol-13-acetate (TPA) and to mitogens such as epidermal growth factor and fibroblast growth factor.	Tetradecanoylphorbol Acetate	193-196	ZFP36 ring finger protein	Homo sapiens	39-44
7527398-2	1994	In cell-free extracts made from gingival fibroblasts treated with platelet-derived growth factor or HepG2 hepatoma cells stimulated with phorbol myristate acetate, MBP and Thr669 kinase were both elevated 4-fold, and ERK1 and ERK2 were tyrosine-phosphorylated.	Tetradecanoylphorbol Acetate	137-162	myelin basic protein	Homo sapiens	164-167
2216454-2	1990	p53 mRNA levels in mouse fibroblasts can be elevated in response to TPA and to serum stimulation.	Tetradecanoylphorbol Acetate	68-71	transformation related protein 53, pseudogene	Mus musculus	0-3
7982907-7	1994	We showed that CD28 signaling, distinct from other stimuli such as phorbol 12-myristate 13-acetate, IL-1, and tumor necrosis factor-alpha, caused a sustained down-regulation of the inhibitor I kappa B alpha in Jurkat T cells.	Tetradecanoylphorbol Acetate	67-98	CD28 molecule	Homo sapiens	15-19
1700492-3	1990	The enhancement of TM expression caused by Bt2cAMP was inhibited by incubation with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	84-115	thrombomodulin	Homo sapiens	19-21
7982915-0	1994	Interferon-gamma- and phorbol myristate acetate-responsive elements involved in intercellular adhesion molecule-1 mRNA stabilization.	Tetradecanoylphorbol Acetate	22-47	intercellular adhesion molecule 1	Mus musculus	80-113
7982915-1	1994	Treatment of cells with interferon (IFN)-gamma or phorbol myristate acetate (PMA) induces up-regulation of the level of intercellular adhesion molecule-1 (ICAM-1; CD54) mRNA by stabilization of an otherwise labile mRNA.	Tetradecanoylphorbol Acetate	50-75	intercellular adhesion molecule 1	Mus musculus	120-153
1701695-6	1990	The EGF-dependent growth stimulation in ER11 cells was inhibited by 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	68-104	epidermal growth factor	Homo sapiens	4-7
7982915-1	1994	Treatment of cells with interferon (IFN)-gamma or phorbol myristate acetate (PMA) induces up-regulation of the level of intercellular adhesion molecule-1 (ICAM-1; CD54) mRNA by stabilization of an otherwise labile mRNA.	Tetradecanoylphorbol Acetate	50-75	intercellular adhesion molecule 1	Mus musculus	155-161
7982915-1	1994	Treatment of cells with interferon (IFN)-gamma or phorbol myristate acetate (PMA) induces up-regulation of the level of intercellular adhesion molecule-1 (ICAM-1; CD54) mRNA by stabilization of an otherwise labile mRNA.	Tetradecanoylphorbol Acetate	50-75	intercellular adhesion molecule 1	Mus musculus	163-167
1701695-6	1990	The EGF-dependent growth stimulation in ER11 cells was inhibited by 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	106-109	epidermal growth factor	Homo sapiens	4-7
7982915-1	1994	Treatment of cells with interferon (IFN)-gamma or phorbol myristate acetate (PMA) induces up-regulation of the level of intercellular adhesion molecule-1 (ICAM-1; CD54) mRNA by stabilization of an otherwise labile mRNA.	Tetradecanoylphorbol Acetate	77-80	intercellular adhesion molecule 1	Mus musculus	120-153
1701695-7	1990	Exposure of NA and ER11 cells to TPA for 30 h resulted in the down-regulation of protein kinase C. In these protein kinase C-deficient cells, EGF was able to activate autophosphorylation of the EGF receptor.	Tetradecanoylphorbol Acetate	33-36	epidermal growth factor	Homo sapiens	142-145
1701695-7	1990	Exposure of NA and ER11 cells to TPA for 30 h resulted in the down-regulation of protein kinase C. In these protein kinase C-deficient cells, EGF was able to activate autophosphorylation of the EGF receptor.	Tetradecanoylphorbol Acetate	33-36	epidermal growth factor	Homo sapiens	194-197
7982915-1	1994	Treatment of cells with interferon (IFN)-gamma or phorbol myristate acetate (PMA) induces up-regulation of the level of intercellular adhesion molecule-1 (ICAM-1; CD54) mRNA by stabilization of an otherwise labile mRNA.	Tetradecanoylphorbol Acetate	77-80	intercellular adhesion molecule 1	Mus musculus	155-161
7982915-1	1994	Treatment of cells with interferon (IFN)-gamma or phorbol myristate acetate (PMA) induces up-regulation of the level of intercellular adhesion molecule-1 (ICAM-1; CD54) mRNA by stabilization of an otherwise labile mRNA.	Tetradecanoylphorbol Acetate	77-80	intercellular adhesion molecule 1	Mus musculus	163-167
7982915-4	1994	In contrast, PMA-induced accumulation of ICAM-1 mRNA required the 3"-untranslated region (UTR).	Tetradecanoylphorbol Acetate	13-16	intercellular adhesion molecule 1	Mus musculus	41-47
7995178-2	1994	An MLCK inhibitor, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine (ML-9), significantly inhibited both the basal pepsinogen secretion and the secretion by carbamylcholine chloride (carbachol) or ionomycin without affecting intracellular free Ca2+ concentration ([Ca2+]i), but not by 12-O-tetradecanoylphorbol-13- acetate (TPA) or forskolin.	Tetradecanoylphorbol Acetate	298-335	myosin light chain kinase 3	Homo sapiens	3-7
2278886-0	1990	Murine c-rel transcription is rapidly induced in T-cells and fibroblasts by mitogenic agents and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	115-151	reticuloendotheliosis oncogene	Mus musculus	7-12
2278886-3	1990	In quiescent fibroblasts, c-rel expression is maximally induced by serum or 12-O-tetradecanoylphorbol-13-acetate within 60 min and is superinduced in serum-stimulated fibroblasts by cycloheximide.	Tetradecanoylphorbol Acetate	76-112	reticuloendotheliosis oncogene	Mus musculus	26-31
2278886-4	1990	In T-cells, although 12-O-tetradecanoylphorbol-13-acetate and concanavalin A both rapidly activate c-rel expression, the kinetics of induction mediated by these agents differs markedly.	Tetradecanoylphorbol Acetate	21-57	reticuloendotheliosis oncogene	Mus musculus	99-104
7995178-2	1994	An MLCK inhibitor, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine (ML-9), significantly inhibited both the basal pepsinogen secretion and the secretion by carbamylcholine chloride (carbachol) or ionomycin without affecting intracellular free Ca2+ concentration ([Ca2+]i), but not by 12-O-tetradecanoylphorbol-13- acetate (TPA) or forskolin.	Tetradecanoylphorbol Acetate	337-340	myosin light chain kinase 3	Homo sapiens	3-7
7886022-3	1994	Inhibin and hCG secretion were stimulated by dexamethasone (0.2 microM), GnRH (5-25 microM), calcium ionophore A23187 (0.2-1 microM), phorbol-12-myristate-13-acetate (22 nM) and epinephrine (1 microM), with increasing response over successive 24-h treatment periods.	Tetradecanoylphorbol Acetate	134-165	chorionic gonadotropin subunit beta 5	Homo sapiens	12-15
1697562-2	1990	Active tumour promoter agents (TPA), such as phorbol ester analogues [phorbol 12-myristate 13-acetate (PMA), phorbol 12, 13-dibutyrate (PBu2)] and mezerein, were able to increase the expression of CD5 on the cell surface of all T-cell lines), as deduced from immunofluorescence and immunoprecipitation analysis.	Tetradecanoylphorbol Acetate	70-101	CD5 molecule	Homo sapiens	197-200
1697562-3	1990	The TPA-induced CD5 up-regulation occurred in a dose-and time-dependent manner and was dependent on protein and RNA synthesis.	Tetradecanoylphorbol Acetate	4-7	CD5 molecule	Homo sapiens	16-19
2115120-5	1990	Cotransfection experiments using separate v-src and neo plasmids revealed a decrease in the number of G418-resistant colonies when transfections of TNR9 cells occurred in the presence of the src-containing plasmid, suggesting a growth inhibitory effect of v-src on 3T3-TNR9 cells, as has also been found for TPA itself.	Tetradecanoylphorbol Acetate	308-311	Rous sarcoma oncogene	Mus musculus	191-194
7961810-4	1994	Basal activity of the gelatinase B promoter in fibroblasts is lower than a collagenase promotor of 1800 base pairs, but activity of both promotors is similarly stimulated by treatment of transfected cells with phorbol 12-myristate 13-acetate, and stimulation is enhanced by co-treatment with transforming growth factor-beta.	Tetradecanoylphorbol Acetate	210-241	matrix metalloproteinase-9	Oryctolagus cuniculus	22-34
2115120-5	1990	Cotransfection experiments using separate v-src and neo plasmids revealed a decrease in the number of G418-resistant colonies when transfections of TNR9 cells occurred in the presence of the src-containing plasmid, suggesting a growth inhibitory effect of v-src on 3T3-TNR9 cells, as has also been found for TPA itself.	Tetradecanoylphorbol Acetate	308-311	Rous sarcoma oncogene	Mus musculus	191-194
7868377-7	1994	Moreover, PKC beta mRNA decreased following treatment with SAC while, on the contrary, it increased following TPA, anti-HLA class II (1.35) mAb, or mitogenic anti-IgM treatment.	Tetradecanoylphorbol Acetate	110-113	protein kinase C beta	Homo sapiens	10-18
2165070-8	1990	In the first pattern, the GM-CSF receptor of neutrophils was rapidly down-regulated by GM-CSF itself, by phorbol myristate acetate (PMA), and by the calcium ionophore A23187, and it was not competed for by IL-3 (class I receptor).	Tetradecanoylphorbol Acetate	105-130	colony stimulating factor 2	Homo sapiens	26-32
2165070-8	1990	In the first pattern, the GM-CSF receptor of neutrophils was rapidly down-regulated by GM-CSF itself, by phorbol myristate acetate (PMA), and by the calcium ionophore A23187, and it was not competed for by IL-3 (class I receptor).	Tetradecanoylphorbol Acetate	132-135	colony stimulating factor 2	Homo sapiens	26-32
2117475-4	1990	In contrast, PAI-1 production was not influenced by diC8, whereas phorbol 12-myristate 13-acetate (PMA) or thrombin stimulated both, tPA and PAI-1 production by HUVEC.	Tetradecanoylphorbol Acetate	66-97	serpin family E member 1	Homo sapiens	141-146
2117475-4	1990	In contrast, PAI-1 production was not influenced by diC8, whereas phorbol 12-myristate 13-acetate (PMA) or thrombin stimulated both, tPA and PAI-1 production by HUVEC.	Tetradecanoylphorbol Acetate	99-102	serpin family E member 1	Homo sapiens	141-146
7963658-3	1994	Therefore, to elucidate pathways that TPA activates in cultured human skin cells, we have examined the levels at which TPA regulates ornithine decarboxylase gene expression in two immortalized human epidermal keratinocyte cell lines, and in normal neonatal keratinocytes.	Tetradecanoylphorbol Acetate	119-122	ornithine decarboxylase 1	Homo sapiens	133-156
2177633-10	1990	5B10 mRNA levels were higher in cells treated with 7,12-dimethylbenzanthracene and 12-O-tetradecanoylphorbol-13-acetate than in their normal counterparts, suggesting a role in tumorigenesis.	Tetradecanoylphorbol Acetate	83-119	S100 calcium binding protein A6 (calcyclin)	Mus musculus	0-4
7969070-2	1994	We report here that in primary mouse keratinocytes PMA caused translocation of PKC-epsilon to the Triton X-100-soluble fraction with an approximately 2-order of magnitude higher potency, compared with translocation of PKC-alpha and PKC-delta.	Tetradecanoylphorbol Acetate	51-54	protein kinase C, epsilon	Mus musculus	79-90
7853145-5	1994	In mastocytoma cells, we demonstrated that the induction of HDC activity and HDC mRNA synergistically occurred on treatment with dexamethasone+TPA, and also cAMP+Ca2+.	Tetradecanoylphorbol Acetate	143-146	histidine decarboxylase	Mus musculus	60-63
2161347-4	1990	After TPA and EGF, the time courses of stimulation of c-fos and c-myc were the same as those for mitogenically stimulated fibroblasts.	Tetradecanoylphorbol Acetate	6-9	MYC proto-oncogene, bHLH transcription factor	Canis lupus familiaris	64-69
7853145-5	1994	In mastocytoma cells, we demonstrated that the induction of HDC activity and HDC mRNA synergistically occurred on treatment with dexamethasone+TPA, and also cAMP+Ca2+.	Tetradecanoylphorbol Acetate	143-146	histidine decarboxylase	Mus musculus	77-80
2178224-5	1990	In addition, we show that IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate transiently induce c-jun and c-fos expression and that retinoic acid inhibits IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate induction of c-fos, but not c-jun.	Tetradecanoylphorbol Acetate	160-197	interleukin 1 alpha	Homo sapiens	26-30
7853145-8	1994	With mastocytoma cells transiently transfected with 5" deletion constructs of HDC-CAT fusion gene, it was found that the sequences from -132 to -53 and -267 to -53 are essential for the regulatory elements involved in the increased transcription of the HDC gene with dexamethasone+TPA and cAMP+Ca2+, respectively.	Tetradecanoylphorbol Acetate	281-284	histidine decarboxylase	Homo sapiens	78-81
7853145-8	1994	With mastocytoma cells transiently transfected with 5" deletion constructs of HDC-CAT fusion gene, it was found that the sequences from -132 to -53 and -267 to -53 are essential for the regulatory elements involved in the increased transcription of the HDC gene with dexamethasone+TPA and cAMP+Ca2+, respectively.	Tetradecanoylphorbol Acetate	281-284	histidine decarboxylase	Mus musculus	253-256
7929127-9	1994	ET-PAFR was also phosphorylated by phorbol 12-myristate 13-acetate (PMA) and dibutyryl cyclic AMP.	Tetradecanoylphorbol Acetate	35-66	platelet-activating factor receptor	Rattus norvegicus	3-7
2119527-5	1990	Phorbol myristate acetate also induced release of t-PA and vWF, though with a different time course; DDAVP was inactive.	Tetradecanoylphorbol Acetate	0-25	plasminogen activator, tissue type	Rattus norvegicus	50-54
7929127-9	1994	ET-PAFR was also phosphorylated by phorbol 12-myristate 13-acetate (PMA) and dibutyryl cyclic AMP.	Tetradecanoylphorbol Acetate	68-71	platelet-activating factor receptor	Rattus norvegicus	3-7
7945263-1	1994	Phorbol 12-myristate 13-acetate (PMA)-stimulated phosphorylation of the human insulin receptor (IR) was characterized and compared in two cell types of different lineage: normal rat kidney epithelial (NRK) cells and Chinese hamster ovary (CHO) fibroblasts.	Tetradecanoylphorbol Acetate	0-31	insulin receptor	Homo sapiens	78-99
7945263-1	1994	Phorbol 12-myristate 13-acetate (PMA)-stimulated phosphorylation of the human insulin receptor (IR) was characterized and compared in two cell types of different lineage: normal rat kidney epithelial (NRK) cells and Chinese hamster ovary (CHO) fibroblasts.	Tetradecanoylphorbol Acetate	33-36	insulin receptor	Homo sapiens	78-99
2161846-5	1990	Stimulation of U937 cells with phorbol 12-myristate 13-acetate was accompanied by a further reduction in receptor-bound uPA inhibition by PAI-1 and PAI-2 to 1.7 x 10(6) and 1.1 x 10(5) M-1 s-1, respectively.	Tetradecanoylphorbol Acetate	31-62	serpin family E member 1	Homo sapiens	138-143
7945263-4	1994	Tryptic phosphopeptide analysis by Tricine/SDS/PAGE revealed significant differences in the PMA-stimulated phosphorylation of the IR in these two cell types.	Tetradecanoylphorbol Acetate	92-95	insulin receptor	Homo sapiens	130-132
2161846-5	1990	Stimulation of U937 cells with phorbol 12-myristate 13-acetate was accompanied by a further reduction in receptor-bound uPA inhibition by PAI-1 and PAI-2 to 1.7 x 10(6) and 1.1 x 10(5) M-1 s-1, respectively.	Tetradecanoylphorbol Acetate	31-62	serpin family B member 2	Homo sapiens	148-153
7945263-9	1994	These results demonstrate that PMA-stimulated phosphorylation of the IR can exhibit significant differences when expressed in different cell types, and that Ser1315 is a major PMA-stimulated phosphorylation site on the human IR.	Tetradecanoylphorbol Acetate	31-34	insulin receptor	Homo sapiens	69-71
7945263-9	1994	These results demonstrate that PMA-stimulated phosphorylation of the IR can exhibit significant differences when expressed in different cell types, and that Ser1315 is a major PMA-stimulated phosphorylation site on the human IR.	Tetradecanoylphorbol Acetate	31-34	insulin receptor	Homo sapiens	225-227
7945263-9	1994	These results demonstrate that PMA-stimulated phosphorylation of the IR can exhibit significant differences when expressed in different cell types, and that Ser1315 is a major PMA-stimulated phosphorylation site on the human IR.	Tetradecanoylphorbol Acetate	176-179	insulin receptor	Homo sapiens	225-227
2115416-4	1990	The production of hydrogen peroxide by phorbol myristate acetate-stimulated peritoneal macrophages of M. avium-infected mice was higher in C57BL/6 and BALB/c mice than in CD-1, DBA/2 and C3H/He animals.	Tetradecanoylphorbol Acetate	39-64	CD1 antigen complex	Mus musculus	171-175
1321047-3	1992	However, PMA-treated foetal cells exhibited a marked stimulation in fructose 2,6-bisphosphate concentration and in PFK-2 activity as well as in the content of hexose phosphates, while no response was found in the case of adult hepatocytes.	Tetradecanoylphorbol Acetate	9-12	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	115-120
7955078-9	1994	Topical application of 5 nmol TPA to the backs of CD-1 mice once a day for 5 days caused epidermal hyperplasia and the levels of c-Jun were increased in the suprabasal layer of the epidermis and in the muscle layer of the dermis.	Tetradecanoylphorbol Acetate	30-33	jun proto-oncogene	Mus musculus	129-134
1427596-10	1992	However, this effect of EGF was counteracted by the pretreatment with TPA or H-7.	Tetradecanoylphorbol Acetate	70-73	epidermal growth factor	Homo sapiens	24-27
2113537-12	1990	However, thrombin-stimulated (1 U/ml) PAF production was enhanced 2.6-fold by preincubation with 100 nM PMA.	Tetradecanoylphorbol Acetate	104-107	PCNA clamp associated factor	Homo sapiens	38-41
7923875-2	1994	Upon stimulation with allergen or anti-CD3+ phorbol myristate acetate (PMA) IL-4 was released with or without IL-5, while no (or extremely low concentrations of) IL-2 and interferon-gamma (IFN-gamma) were detectable.	Tetradecanoylphorbol Acetate	44-69	interleukin 5	Homo sapiens	110-114
2113537-13	1990	The protein kinase C inhibitors H-7 and staurosporine ablated the enhancing effect of PMA on thrombin-stimulated PGI2 and PAF biosynthesis.	Tetradecanoylphorbol Acetate	86-89	PCNA clamp associated factor	Homo sapiens	122-125
1535685-1	1992	Rat 6 fibroblasts that overproduce protein kinase C beta 1 (R6-PKC3 cells) are hypersensitive to complete transformation by the T24 H-ras oncogene; yet T24 H-ras-transformed R6-PKC3 cells are killed when exposed to 12-O-tetradecanoylphorbol-13-acetate (TPA) (W.-L. W. Hsiao, G. M. Housey, M. D. Johnson, and I.	Tetradecanoylphorbol Acetate	215-251	HRas proto-oncogene, GTPase	Homo sapiens	156-161
7923875-2	1994	Upon stimulation with allergen or anti-CD3+ phorbol myristate acetate (PMA) IL-4 was released with or without IL-5, while no (or extremely low concentrations of) IL-2 and interferon-gamma (IFN-gamma) were detectable.	Tetradecanoylphorbol Acetate	71-74	interleukin 5	Homo sapiens	110-114
2111009-0	1990	The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein.	Tetradecanoylphorbol Acetate	14-17	early growth response 2	Homo sapiens	67-71
7929831-2	1994	We now report that melanocyte stimulation with phorbol 12-tetra decanoate 13-acetate (TPA), previously reported to induce p75 NGF receptor, also induces trk in melanocytes, and TPA effect is further potentiated by the presence of keratinocytes in culture.	Tetradecanoylphorbol Acetate	86-89	neurotrophic receptor tyrosine kinase 1	Homo sapiens	153-156
1694132-4	1990	Treatment with direct activators of protein kinase C (PKC), the phorbol ester phorbol 12-myristate 13-acetate (PMA) or the natural agent bryostatin 1 (Bryo), caused increased CD5 mRNA expression after 8-16 h of incubation.	Tetradecanoylphorbol Acetate	78-109	CD5 molecule	Homo sapiens	175-178
1596565-4	1992	When cultured human umbilical vein endothelial cells were stimulated (in 10% fetal bovine serum) with phorbol myristate acetate (PMA), endotoxin, interleukin-1, or tumor necrosis factor-alpha, the TF mRNA increased approximately 7- to 10-fold within 2 to 4 hours.	Tetradecanoylphorbol Acetate	102-127	coagulation factor III, tissue factor	Homo sapiens	197-199
1694132-4	1990	Treatment with direct activators of protein kinase C (PKC), the phorbol ester phorbol 12-myristate 13-acetate (PMA) or the natural agent bryostatin 1 (Bryo), caused increased CD5 mRNA expression after 8-16 h of incubation.	Tetradecanoylphorbol Acetate	111-114	CD5 molecule	Homo sapiens	175-178
7916295-3	1994	We observed that phorbol 12-myristate 13-acetate, Mn2+, cross-linking of CD3 or activating antibodies against LFA-1 enhanced LFA-1-mediated T cell adhesion to ICAM-2 and -3, although to a lesser extent than to ICAM-1.	Tetradecanoylphorbol Acetate	17-48	integrin subunit alpha L	Homo sapiens	125-130
1534243-5	1992	Recently, an IL-1 receptor antagonist (IRAP) has been isolated, purified, and cloned from peripheral blood monocytes (PBM) stimulated with either adherent IgG (adhIgG) lipopolysaccharide (LPS), or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	197-222	interleukin 1 receptor antagonist	Homo sapiens	13-37
7531203-9	1994	Ultraviolet radiation induced a small increase in MARCKS protein phosphorylation but this effect was inhibited by pretreatment for 24 hours with 500 nM TPA, which had no effect on ultraviolet-induced melanogenesis.	Tetradecanoylphorbol Acetate	152-155	myristoylated alanine rich protein kinase C substrate	Homo sapiens	50-56
1534243-5	1992	Recently, an IL-1 receptor antagonist (IRAP) has been isolated, purified, and cloned from peripheral blood monocytes (PBM) stimulated with either adherent IgG (adhIgG) lipopolysaccharide (LPS), or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	197-222	interleukin 1 receptor antagonist	Homo sapiens	39-43
2158424-15	1990	GH secretion in response to other secretagogues, such as 12-O-tetradecanoyl-phorbol-13-acetate, forskolin, cholera toxin, and 8-bromo-cAMP, was also suppressed after activin-A pretreatment.	Tetradecanoylphorbol Acetate	57-94	inhibin subunit beta A	Rattus norvegicus	166-175
1378917-9	1992	Following exposure to TPA the 50-55 kD species was reduced over 48-72 h while the level of the p33-37 CD20 protein was increased.	Tetradecanoylphorbol Acetate	22-25	inhibitor of growth family member 1	Homo sapiens	95-98
7804156-7	1994	Phorbol 12-myristate 13-acetate, which has been shown to activate IP3 5"-phosphatase through protein kinase C, stimulates the increase in cytoskeletal actin.	Tetradecanoylphorbol Acetate	0-31	actin alpha 2, smooth muscle	Sus scrofa	151-156
1971316-4	1990	However, after stimulation of the T cells with the combination of phorbol-12-myristate-13-acetate (PMA) and ionomycin to bypass CD3, 3 out of 6 old mice still exhibited 2-fold lower proliferative responses than T cells from young mice; IL-2 production by the CD4+ T cells was lower in all old mice tested.	Tetradecanoylphorbol Acetate	66-97	interleukin 2	Mus musculus	236-240
7519584-9	1994	Finally, studies with FAPlow leptomeningeal fibroblasts revealed that transforming growth factor-beta, 12-O-tetradecanoyl phorbol-13-acetate and retinoids can upregulate FAP expression, whereas serum and several other factors had no or little effect on FAP levels.	Tetradecanoylphorbol Acetate	103-140	fibroblast activation protein alpha	Homo sapiens	22-25
1971316-4	1990	However, after stimulation of the T cells with the combination of phorbol-12-myristate-13-acetate (PMA) and ionomycin to bypass CD3, 3 out of 6 old mice still exhibited 2-fold lower proliferative responses than T cells from young mice; IL-2 production by the CD4+ T cells was lower in all old mice tested.	Tetradecanoylphorbol Acetate	99-102	interleukin 2	Mus musculus	236-240
1375459-1	1992	Neutrophil adherence to endothelium is partially mediated by the expression of endothelial leukocyte adhesion molecule-1 (ELAM-1) on endothelial cells activated by agents such as lipopolysaccharide (LPS) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	208-233	selectin E	Homo sapiens	79-120
1375459-1	1992	Neutrophil adherence to endothelium is partially mediated by the expression of endothelial leukocyte adhesion molecule-1 (ELAM-1) on endothelial cells activated by agents such as lipopolysaccharide (LPS) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	208-233	selectin E	Homo sapiens	122-128
1375459-1	1992	Neutrophil adherence to endothelium is partially mediated by the expression of endothelial leukocyte adhesion molecule-1 (ELAM-1) on endothelial cells activated by agents such as lipopolysaccharide (LPS) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	235-238	selectin E	Homo sapiens	79-120
1375459-1	1992	Neutrophil adherence to endothelium is partially mediated by the expression of endothelial leukocyte adhesion molecule-1 (ELAM-1) on endothelial cells activated by agents such as lipopolysaccharide (LPS) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	235-238	selectin E	Homo sapiens	122-128
7519584-9	1994	Finally, studies with FAPlow leptomeningeal fibroblasts revealed that transforming growth factor-beta, 12-O-tetradecanoyl phorbol-13-acetate and retinoids can upregulate FAP expression, whereas serum and several other factors had no or little effect on FAP levels.	Tetradecanoylphorbol Acetate	103-140	fibroblast activation protein alpha	Homo sapiens	170-173
2351153-3	1990	In this study, we show by both, hybridization analysis of RNA and immunoblotting that an enhanced expression of the intermediate filament (IF) subunit proteins vimentin, lamin A and lamin C accompanied the TPA-induced differentiation process.	Tetradecanoylphorbol Acetate	206-209	vimentin	Homo sapiens	160-168
7519620-13	1994	Also other activators of beta 2 integrins such as phorbol-12-myristate 13-acetate (PMA), and formyl methionyl-leucyl-phenylalanine (FMLP), induced activation of p58fgr kinase activity.	Tetradecanoylphorbol Acetate	50-81	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	25-31
7519620-13	1994	Also other activators of beta 2 integrins such as phorbol-12-myristate 13-acetate (PMA), and formyl methionyl-leucyl-phenylalanine (FMLP), induced activation of p58fgr kinase activity.	Tetradecanoylphorbol Acetate	83-86	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	25-31
2160828-4	1990	The change in pHi in response to IGF-I was mimicked by phorbol 12-myristate 13-acetate (PMA; 100 nmol/l), an activator of thyroid cell proliferation.	Tetradecanoylphorbol Acetate	55-86	glucose-6-phosphate isomerase	Rattus norvegicus	14-17
1316727-7	1992	Ceruloplasmin that was present in the BALF and serum samples had functional oxidase activity, and purified human ceruloplasmin inhibited hydroxyl radical formation by phorbol myristate acetate (PMA)-stimulated neutrophils.	Tetradecanoylphorbol Acetate	167-192	ceruloplasmin	Homo sapiens	0-13
1316727-7	1992	Ceruloplasmin that was present in the BALF and serum samples had functional oxidase activity, and purified human ceruloplasmin inhibited hydroxyl radical formation by phorbol myristate acetate (PMA)-stimulated neutrophils.	Tetradecanoylphorbol Acetate	167-192	ceruloplasmin	Homo sapiens	113-126
1316727-7	1992	Ceruloplasmin that was present in the BALF and serum samples had functional oxidase activity, and purified human ceruloplasmin inhibited hydroxyl radical formation by phorbol myristate acetate (PMA)-stimulated neutrophils.	Tetradecanoylphorbol Acetate	194-197	ceruloplasmin	Homo sapiens	0-13
2160828-4	1990	The change in pHi in response to IGF-I was mimicked by phorbol 12-myristate 13-acetate (PMA; 100 nmol/l), an activator of thyroid cell proliferation.	Tetradecanoylphorbol Acetate	55-86	insulin-like growth factor 1	Rattus norvegicus	33-38
2160828-4	1990	The change in pHi in response to IGF-I was mimicked by phorbol 12-myristate 13-acetate (PMA; 100 nmol/l), an activator of thyroid cell proliferation.	Tetradecanoylphorbol Acetate	88-91	glucose-6-phosphate isomerase	Rattus norvegicus	14-17
2160828-4	1990	The change in pHi in response to IGF-I was mimicked by phorbol 12-myristate 13-acetate (PMA; 100 nmol/l), an activator of thyroid cell proliferation.	Tetradecanoylphorbol Acetate	88-91	insulin-like growth factor 1	Rattus norvegicus	33-38
8035171-2	1994	Treatment of astrocytes with interleukin-1 beta (IL-1) or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased NGF mRNA content by six- to 10-fold, followed in time by increases in cell content and cell secretion of NGF.	Tetradecanoylphorbol Acetate	95-131	nerve growth factor	Rattus norvegicus	148-151
2138707-1	1990	Proto-oncogene products c-Fos and c-Jun form a complex which binds with high affinity to the 12-O-tetradecanoylphorbol-13-acetate (TPA) response DNA element and which stimulates transcription of phorbol ester- inducible genes.	Tetradecanoylphorbol Acetate	131-134	FBJ osteosarcoma oncogene	Mus musculus	24-29
8035171-2	1994	Treatment of astrocytes with interleukin-1 beta (IL-1) or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased NGF mRNA content by six- to 10-fold, followed in time by increases in cell content and cell secretion of NGF.	Tetradecanoylphorbol Acetate	95-131	nerve growth factor	Rattus norvegicus	253-256
1316727-7	1992	Ceruloplasmin that was present in the BALF and serum samples had functional oxidase activity, and purified human ceruloplasmin inhibited hydroxyl radical formation by phorbol myristate acetate (PMA)-stimulated neutrophils.	Tetradecanoylphorbol Acetate	194-197	ceruloplasmin	Homo sapiens	113-126
8035171-2	1994	Treatment of astrocytes with interleukin-1 beta (IL-1) or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased NGF mRNA content by six- to 10-fold, followed in time by increases in cell content and cell secretion of NGF.	Tetradecanoylphorbol Acetate	133-136	nerve growth factor	Rattus norvegicus	148-151
2108162-5	1990	Phorbol myristate acetate (PMA), as well as 1-oleoyl-2-acetylglycerol, also enhanced PLA2 activity.	Tetradecanoylphorbol Acetate	0-25	phospholipase A2 group IB	Rattus norvegicus	85-89
8035171-2	1994	Treatment of astrocytes with interleukin-1 beta (IL-1) or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased NGF mRNA content by six- to 10-fold, followed in time by increases in cell content and cell secretion of NGF.	Tetradecanoylphorbol Acetate	133-136	nerve growth factor	Rattus norvegicus	253-256
2108162-5	1990	Phorbol myristate acetate (PMA), as well as 1-oleoyl-2-acetylglycerol, also enhanced PLA2 activity.	Tetradecanoylphorbol Acetate	27-30	phospholipase A2 group IB	Rattus norvegicus	85-89
8035171-3	1994	Dexamethasone potently inhibited the effects of IL-1 and TPA on astroglial cell NGF expression.	Tetradecanoylphorbol Acetate	57-60	nerve growth factor	Rattus norvegicus	80-83
2108162-9	1990	Down-regulation of protein kinase C by pretreatment with PMA resulted in loss of the PMA-induced, but not the EGF-induced, enhancement in PLA2 activity.	Tetradecanoylphorbol Acetate	57-60	phospholipase A2 group IB	Rattus norvegicus	138-142
8034037-2	1994	We show that a binding sequence for the transcription factor IRF-1 is contained in the first intron of the human ODC gene (from nt +2711 to nt +2722) and we demonstrate that the level of expression of IRF-1 increases in human macrophages and in the human promonocytic cell line, U937, previously differentiated in monocytes/macrophages by phorbol myristate acetate (PMA), after 2 h of IFN gamma stimulation.	Tetradecanoylphorbol Acetate	339-364	ornithine decarboxylase 1	Homo sapiens	113-116
1398515-3	1992	On activation with 12-O-tetradecanoylphorbol-13-acetate (TPA) these cells express the CD3 antigen and the T cell receptor alpha beta (TCR alpha beta) on the cell surface.	Tetradecanoylphorbol Acetate	19-55	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	134-137
1398515-3	1992	On activation with 12-O-tetradecanoylphorbol-13-acetate (TPA) these cells express the CD3 antigen and the T cell receptor alpha beta (TCR alpha beta) on the cell surface.	Tetradecanoylphorbol Acetate	57-60	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	134-137
2159354-1	1990	The present work describes the ability of Met- and Leu-enkephalin to modulate the superoxide anion (O2-) release from unstimulated human polymorphonuclear cells (PMN) and from PMN stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	196-221	prodynorphin	Homo sapiens	51-65
8027056-8	1994	In addition, both TPA and IL-1 alpha caused increases not only in the phosphorylation of c-Jun and c-Fos protein but also in the transactivating activity of AP-1 nuclear transcription factor.	Tetradecanoylphorbol Acetate	18-21	jun proto-oncogene	Mus musculus	89-94
2159354-1	1990	The present work describes the ability of Met- and Leu-enkephalin to modulate the superoxide anion (O2-) release from unstimulated human polymorphonuclear cells (PMN) and from PMN stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	223-226	prodynorphin	Homo sapiens	51-65
1398515-5	1992	Supernatants of TPA-stimulated Co cells contained the cytokines IL2, IL3, IL4 and IL8, whereas these cytokines were not detected in the supernatants of untreated cells.	Tetradecanoylphorbol Acetate	16-19	interleukin 3	Homo sapiens	69-72
1398515-6	1992	Different subclones of the Co cell line differed in their response to TPA with respect to the induced CD3 and TCR expression.	Tetradecanoylphorbol Acetate	70-73	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	110-113
7818986-8	1994	Phosphatidylserine and phorbol 12-myristate 13-acetate (PMA)-dependent KP-10 phosphorylating activity was immunoprecipitated by anti-PKC eta and zeta antibodies, but not by antiPKC alpha antibody.	Tetradecanoylphorbol Acetate	56-59	endothelin receptor type A	Mus musculus	49-52
1631796-3	1992	Cells down-regulated for the tissue factor response to TPA responded essentially normally to endotoxin and interleukin-1 with regard to tissue factor synthesis.	Tetradecanoylphorbol Acetate	55-58	coagulation factor III, tissue factor	Homo sapiens	29-42
1631796-3	1992	Cells down-regulated for the tissue factor response to TPA responded essentially normally to endotoxin and interleukin-1 with regard to tissue factor synthesis.	Tetradecanoylphorbol Acetate	55-58	coagulation factor III, tissue factor	Homo sapiens	136-149
2188740-4	1990	In the presence of a tumor promoter (TPA), the HEL cells maintained their heterogenous vimentin immunoreactivity, but some cells showed large bundles of cytoplasmic vimentin fibrils.	Tetradecanoylphorbol Acetate	37-40	vimentin	Homo sapiens	87-95
2188740-4	1990	In the presence of a tumor promoter (TPA), the HEL cells maintained their heterogenous vimentin immunoreactivity, but some cells showed large bundles of cytoplasmic vimentin fibrils.	Tetradecanoylphorbol Acetate	37-40	vimentin	Homo sapiens	165-173
7913440-0	1994	Enhanced production of pituitary adenylate-cyclase-activating polypeptide by 1, N6-dibutyryladenosine 3",5"-monophosphate, phorbol 12-myristate 13-acetate and by the polypeptide itself in human neuroblastoma cells, IMR-32.	Tetradecanoylphorbol Acetate	123-154	adenylate cyclase activating polypeptide 1	Homo sapiens	23-73
1968888-4	1990	In each case, however, stimulation of neutrophils with phorbol ester (PMA) abolished CD11/CD18-independent adherence to LPS-pretreated HEC (less than 5% adherence).	Tetradecanoylphorbol Acetate	70-73	lymphotoxin beta receptor	Homo sapiens	90-94
2307845-9	1990	THP-1 cells express low levels of an abnormally sized mRNA for PAI-2 and demonstrate a regulatory defect whereby steady state levels of PAI-2 mRNA are markedly reduced upon stimulation with PMA or LPS.	Tetradecanoylphorbol Acetate	190-193	serpin family B member 2	Homo sapiens	63-68
2307845-9	1990	THP-1 cells express low levels of an abnormally sized mRNA for PAI-2 and demonstrate a regulatory defect whereby steady state levels of PAI-2 mRNA are markedly reduced upon stimulation with PMA or LPS.	Tetradecanoylphorbol Acetate	190-193	serpin family B member 2	Homo sapiens	136-141
1531944-5	1992	In vitro stimulation of T cells with concanavalin A or calcium ionophore and phorbol myristate acetate (PMA) for 1-4 hr caused a marked (7- to 12-fold) increase in lymphocyte adhesion to unstimulated and IFN-gamma- or LPS-treated EC.	Tetradecanoylphorbol Acetate	77-102	interferon gamma	Rattus norvegicus	204-213
1531944-5	1992	In vitro stimulation of T cells with concanavalin A or calcium ionophore and phorbol myristate acetate (PMA) for 1-4 hr caused a marked (7- to 12-fold) increase in lymphocyte adhesion to unstimulated and IFN-gamma- or LPS-treated EC.	Tetradecanoylphorbol Acetate	104-107	interferon gamma	Rattus norvegicus	204-213
1372239-4	1992	IL-1 alpha amplified the effect of phorbol myristate acetate to increase the VIP content of chromaffin cells, but antagonized phorbol ester-induced elevation of neurotensin levels.	Tetradecanoylphorbol Acetate	35-60	interleukin 1 alpha	Homo sapiens	0-10
8043198-0	1994	Non-AP-1 tumor promoter 12-O-tetradecanoylphorbol-13-acetate-responsive sequences in the human ornithine decarboxylase gene.	Tetradecanoylphorbol Acetate	24-60	ornithine decarboxylase 1	Homo sapiens	95-118
2157034-2	1990	Their superoxide production at rest and following stimulation with either serum-treated zymosan (STZ) or phorbol myristate acetate (PMA) was measured by cytochrome-c reduction.	Tetradecanoylphorbol Acetate	105-130	cytochrome c, somatic	Equus caballus	153-165
2157034-2	1990	Their superoxide production at rest and following stimulation with either serum-treated zymosan (STZ) or phorbol myristate acetate (PMA) was measured by cytochrome-c reduction.	Tetradecanoylphorbol Acetate	132-135	cytochrome c, somatic	Equus caballus	153-165
8043198-1	1994	To define the mechanisms of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcription of the ornithine decarboxylase (ODC) gene, we isolated a genomic clone (hODC41B) of ODC from a human leukocyte genomic DNA library.	Tetradecanoylphorbol Acetate	28-64	ornithine decarboxylase 1	Homo sapiens	100-123
2157034-5	1990	The maximum inhibition of the cytochrome-c reduction by superoxide dismutase (Palosein) was 83.6% (STZ stimulation) and 72.1% (PMA stimulation).	Tetradecanoylphorbol Acetate	127-130	cytochrome c, somatic	Equus caballus	30-42
1317350-2	1992	Phorbol myristate acetate (PMA), calcium ionophore, plasma-activated zymosan, concanavalin A and recombinant human anaphylatoxin C5a induced the release of varying amounts of EPO.	Tetradecanoylphorbol Acetate	0-25	eosinophil peroxidase	Cavia porcellus	175-178
8043198-1	1994	To define the mechanisms of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcription of the ornithine decarboxylase (ODC) gene, we isolated a genomic clone (hODC41B) of ODC from a human leukocyte genomic DNA library.	Tetradecanoylphorbol Acetate	28-64	ornithine decarboxylase 1	Homo sapiens	125-128
1317350-2	1992	Phorbol myristate acetate (PMA), calcium ionophore, plasma-activated zymosan, concanavalin A and recombinant human anaphylatoxin C5a induced the release of varying amounts of EPO.	Tetradecanoylphorbol Acetate	27-30	eosinophil peroxidase	Cavia porcellus	175-178
8043198-1	1994	To define the mechanisms of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcription of the ornithine decarboxylase (ODC) gene, we isolated a genomic clone (hODC41B) of ODC from a human leukocyte genomic DNA library.	Tetradecanoylphorbol Acetate	28-64	ornithine decarboxylase 1	Homo sapiens	166-169
8043198-1	1994	To define the mechanisms of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcription of the ornithine decarboxylase (ODC) gene, we isolated a genomic clone (hODC41B) of ODC from a human leukocyte genomic DNA library.	Tetradecanoylphorbol Acetate	66-69	ornithine decarboxylase 1	Homo sapiens	100-123
1312371-2	1992	Among growth factors studied, granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage-CSF (M-CSF), and interleukin-3 (IL-3) primed human monocytes and enhanced O2- release stimulated by the receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A), but not by phorbol myristate acetate, which bypasses the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	318-343	colony stimulating factor 2	Homo sapiens	30-78
1312371-2	1992	Among growth factors studied, granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage-CSF (M-CSF), and interleukin-3 (IL-3) primed human monocytes and enhanced O2- release stimulated by the receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A), but not by phorbol myristate acetate, which bypasses the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	318-343	interleukin 3	Homo sapiens	117-130
2107492-5	1990	Further, we show here that although EGF- and TPA-stimulated induction of c-fos is abolished by 2-aminopurine, the appearance of TRE-binding activity in nuclear extracts of stimulated cells is unaffected, suggesting that EGF- and TPA-stimulated induction of TRE-binding activity utilises existing proteins and is not dependent on fresh c-FOS synthesis.	Tetradecanoylphorbol Acetate	45-48	epidermal growth factor	Homo sapiens	220-223
1312371-2	1992	Among growth factors studied, granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage-CSF (M-CSF), and interleukin-3 (IL-3) primed human monocytes and enhanced O2- release stimulated by the receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A), but not by phorbol myristate acetate, which bypasses the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	318-343	interleukin 3	Homo sapiens	132-136
8043198-1	1994	To define the mechanisms of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcription of the ornithine decarboxylase (ODC) gene, we isolated a genomic clone (hODC41B) of ODC from a human leukocyte genomic DNA library.	Tetradecanoylphorbol Acetate	66-69	ornithine decarboxylase 1	Homo sapiens	125-128
2111050-8	1990	This plasma clot test reflects the ability of free tPA to bind to fibrin (the amount of which depends on the level of tPA and PAI-1), and may be useful in the diagnosis of a hypofibrinolytic state.	Tetradecanoylphorbol Acetate	51-54	serpin family E member 1	Homo sapiens	126-131
8043198-1	1994	To define the mechanisms of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transcription of the ornithine decarboxylase (ODC) gene, we isolated a genomic clone (hODC41B) of ODC from a human leukocyte genomic DNA library.	Tetradecanoylphorbol Acetate	66-69	ornithine decarboxylase 1	Homo sapiens	166-169
2105318-2	1990	Activators of PKC such as phorbol 12-myristate 13-acetate (PMA) or 1-oleoyl 2-acetyl glycerol mimicked the stimulatory effect of NGF and bFGF on SCG10 mRNA levels.	Tetradecanoylphorbol Acetate	26-57	stathmin 2	Rattus norvegicus	145-150
8043198-9	1994	The TPA induction from the construct -72 ODC CAT was threefold to sevenfold, and the TPA inducibility of the same fragment was about ninefold to 30-fold with the luciferase reporter gene.	Tetradecanoylphorbol Acetate	4-7	ornithine decarboxylase 1	Homo sapiens	41-44
2105318-2	1990	Activators of PKC such as phorbol 12-myristate 13-acetate (PMA) or 1-oleoyl 2-acetyl glycerol mimicked the stimulatory effect of NGF and bFGF on SCG10 mRNA levels.	Tetradecanoylphorbol Acetate	59-62	stathmin 2	Rattus norvegicus	145-150
1371717-5	1992	However, the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a direct activator of PKC, showed a time- and dose-dependent repression of the androgen regulation of PSA glycoprotein and mRNA.	Tetradecanoylphorbol Acetate	27-64	kallikrein related peptidase 3	Homo sapiens	174-177
1371717-5	1992	However, the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a direct activator of PKC, showed a time- and dose-dependent repression of the androgen regulation of PSA glycoprotein and mRNA.	Tetradecanoylphorbol Acetate	66-69	kallikrein related peptidase 3	Homo sapiens	174-177
1371717-7	1992	Staurosporine, a PKC inhibitor, blocked the TPA-mediated repression of the androgenic stimulation of PSA glycoprotein.	Tetradecanoylphorbol Acetate	44-47	kallikrein related peptidase 3	Homo sapiens	101-104
8043198-10	1994	Further deletion analysis revealed TPA-responsive sequences in ODC nt -42 to +54.	Tetradecanoylphorbol Acetate	35-38	ornithine decarboxylase 1	Homo sapiens	63-66
2305865-7	1990	Phosphorylation of p83 also occurs when a T84 cell extract is incubated with purified protein kinase C and when intact cells are exposed to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	140-165	Rho related BTB domain containing 2	Homo sapiens	19-22
7515882-7	1994	Insulin and TPA also stimulated MAPK (&gt; 2-fold increase over basal, with myelin basic protein as a substrate).	Tetradecanoylphorbol Acetate	12-15	myelin basic protein	Homo sapiens	76-96
8205621-1	1994	T lymphocyte activation and interleukin-2 (IL-2) production require at least two signals, generated by phorbol ester (TPA) and Ca2+ ionophore or costimulation of the T cell receptor (TCR) and the CD28 auxiliary receptor.	Tetradecanoylphorbol Acetate	118-121	CD28 molecule	Homo sapiens	196-200
2106323-4	1990	Treatment of cell cultures with phenobarbital or 3,4,3",4"-tetrachlorobiphenyl (enzyme inducers and tumor promoters in vivo) or with 12-O-tetradecanoylphorbol-13-acetate (the classical skin tumor promoter) further increased EGF-stimulated DNA synthesis.	Tetradecanoylphorbol Acetate	133-169	epidermal growth factor	Mus musculus	224-227
7514999-6	1994	In addition, follistatin (25 ng/ml) inhibited hCG secretion in response to phorbol 12-myristate 13-acetate (100 nM) by 90.3%.	Tetradecanoylphorbol Acetate	75-106	glycoprotein hormones, alpha polypeptide	Homo sapiens	46-49
1531455-4	1992	In DBA/2 mice there was no age-related difference in IL-2 production with anti-CD3 mAb activation alone, whereas when the same cell population was activated with anti-CD3 mAb and TPA an age-associated decrease in IL-2 production occurred.	Tetradecanoylphorbol Acetate	179-182	interleukin 2	Mus musculus	213-217
1531455-6	1992	After addition of TPA, however, there was an age-related decrease in IL-4 production.	Tetradecanoylphorbol Acetate	18-21	interleukin 4	Mus musculus	69-73
8189216-2	1994	Treatment of WKY rat brain cultures with a phorbol ester, phorbol 12-myristate 13-acetate (PMA), causes a time- and dose-dependent increase in the levels of an approximately 2.3-kb AT1 receptor mRNA transcript.	Tetradecanoylphorbol Acetate	58-89	angiotensin II receptor, type 1a	Rattus norvegicus	181-184
2336792-8	1990	It was observed that coincubation of PMA with PAF, or A23187 resulted in an inhibition of beta-glucuronidase secretion and an enhancement of myeloperoxidase secretion, respectively.	Tetradecanoylphorbol Acetate	37-40	myeloperoxidase	Bos taurus	141-156
8189216-2	1994	Treatment of WKY rat brain cultures with a phorbol ester, phorbol 12-myristate 13-acetate (PMA), causes a time- and dose-dependent increase in the levels of an approximately 2.3-kb AT1 receptor mRNA transcript.	Tetradecanoylphorbol Acetate	91-94	angiotensin II receptor, type 1a	Rattus norvegicus	181-184
1541284-9	1992	The priming effect of GM-CSF could be mimicked by phorbol myristate acetate (PMA; 1 nM) and no additive or synergistic effect was found on leukotriene biosynthesis by simultaneous pretreatment with PMA and GM-CSF and stimulation with either fMLP or ionomycin.	Tetradecanoylphorbol Acetate	50-75	colony stimulating factor 2	Homo sapiens	22-28
7909823-6	1994	Primed cells are enriched in CD45R0hi and CD31- cells, and upon stimulation with PMA+ ionomycin they release significant amounts of IL-2, IFN-gamma, IL-4, IL-5, and IL-10.	Tetradecanoylphorbol Acetate	81-84	platelet and endothelial cell adhesion molecule 1	Homo sapiens	42-46
1541284-9	1992	The priming effect of GM-CSF could be mimicked by phorbol myristate acetate (PMA; 1 nM) and no additive or synergistic effect was found on leukotriene biosynthesis by simultaneous pretreatment with PMA and GM-CSF and stimulation with either fMLP or ionomycin.	Tetradecanoylphorbol Acetate	77-80	colony stimulating factor 2	Homo sapiens	22-28
2297525-6	1990	Peroxisomal beta-oxidation was increased about 2-fold in the peroxisome-enriched fraction of TPA-treated rats while the catalase and urate oxidase activities were only marginally affected.	Tetradecanoylphorbol Acetate	93-96	urate oxidase	Rattus norvegicus	133-146
7909823-6	1994	Primed cells are enriched in CD45R0hi and CD31- cells, and upon stimulation with PMA+ ionomycin they release significant amounts of IL-2, IFN-gamma, IL-4, IL-5, and IL-10.	Tetradecanoylphorbol Acetate	81-84	interleukin 5	Homo sapiens	155-159
1545152-5	1992	PMA-stimulated CMK lines synthesized low levels of TNF-alpha and IL-6, and higher levels of GM-CSF, IL-1 beta, and IL-1 alpha protein.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 2	Homo sapiens	92-98
8174639-9	1994	Production of hHGF in both cell strains was remarkably stimulated by treatment with 10 nM PMA.	Tetradecanoylphorbol Acetate	90-93	hepatocyte growth factor	Homo sapiens	14-18
1545152-5	1992	PMA-stimulated CMK lines synthesized low levels of TNF-alpha and IL-6, and higher levels of GM-CSF, IL-1 beta, and IL-1 alpha protein.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 alpha	Homo sapiens	115-125
2295806-3	1990	Although the populations of CTMC acted on by TPA and IL-4 seemed to be close to each other, the velocity of colony growth induced by the simultaneous stimulation of the combination of TPA and IL-4 was faster than that induced by either TPA or IL-4 in the presence of IL-3.	Tetradecanoylphorbol Acetate	184-187	interleukin 3	Homo sapiens	267-271
2295806-5	1990	These results suggest that TPA and IL-4 act on the proliferation of CTMC synergistically with IL-3 via a different pathway.	Tetradecanoylphorbol Acetate	27-30	interleukin 3	Homo sapiens	94-98
8182143-4	1994	In PMA-stimulated neutrophils and in a cell-free translocation assay with neutrophil membranes and cytosol, the association of the cytosolic proteins p47-phox and p67-phox with the membrane fraction of the patient was strongly disturbed.	Tetradecanoylphorbol Acetate	3-6	neutrophil cytosolic factor 2	Homo sapiens	163-171
1350054-2	1992	Incubation of NPLC cells with 100 nM 12-O-tetradecanoyl phorbol 13-acetate (TPA), a phorbol ester that activates protein kinase-C, resulted in a rapid (1-h) and prolonged (72-h) increase in CRH mRNA levels, with the maximum increase of 16-fold observed at 24 h. In addition, TPA treatment increased the size of CRH mRNA by approximately 100 nucleotides.	Tetradecanoylphorbol Acetate	37-74	corticotropin releasing hormone	Homo sapiens	190-193
8152801-2	1994	We examined c-ski expression in four different myeloid cell lines which can be induced to differentiate by exposure to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	119-150	SKI proto-oncogene	Gallus gallus	12-17
1350054-2	1992	Incubation of NPLC cells with 100 nM 12-O-tetradecanoyl phorbol 13-acetate (TPA), a phorbol ester that activates protein kinase-C, resulted in a rapid (1-h) and prolonged (72-h) increase in CRH mRNA levels, with the maximum increase of 16-fold observed at 24 h. In addition, TPA treatment increased the size of CRH mRNA by approximately 100 nucleotides.	Tetradecanoylphorbol Acetate	37-74	corticotropin releasing hormone	Homo sapiens	311-314
1350054-2	1992	Incubation of NPLC cells with 100 nM 12-O-tetradecanoyl phorbol 13-acetate (TPA), a phorbol ester that activates protein kinase-C, resulted in a rapid (1-h) and prolonged (72-h) increase in CRH mRNA levels, with the maximum increase of 16-fold observed at 24 h. In addition, TPA treatment increased the size of CRH mRNA by approximately 100 nucleotides.	Tetradecanoylphorbol Acetate	76-79	corticotropin releasing hormone	Homo sapiens	190-193
1350054-2	1992	Incubation of NPLC cells with 100 nM 12-O-tetradecanoyl phorbol 13-acetate (TPA), a phorbol ester that activates protein kinase-C, resulted in a rapid (1-h) and prolonged (72-h) increase in CRH mRNA levels, with the maximum increase of 16-fold observed at 24 h. In addition, TPA treatment increased the size of CRH mRNA by approximately 100 nucleotides.	Tetradecanoylphorbol Acetate	76-79	corticotropin releasing hormone	Homo sapiens	311-314
1350054-3	1992	This size increase, which was blocked by protein synthesis inhibitors, occurred within 1 h of TPA addition and lasted at least 8 h, with a return toward the baseline size by 24 h. Structural analysis of CRH mRNA revealed two poly(A) addition sites and, as found in human placenta, multiple transcription start sites.	Tetradecanoylphorbol Acetate	94-97	corticotropin releasing hormone	Homo sapiens	203-206
1350054-5	1992	The ability of TPA to increase CRH mRNA levels in NPLC cells suggests that the protein kinase-C second messenger pathway may be involved in the physiological regulation of CRH gene expression.	Tetradecanoylphorbol Acetate	15-18	corticotropin releasing hormone	Homo sapiens	31-34
1350054-5	1992	The ability of TPA to increase CRH mRNA levels in NPLC cells suggests that the protein kinase-C second messenger pathway may be involved in the physiological regulation of CRH gene expression.	Tetradecanoylphorbol Acetate	15-18	corticotropin releasing hormone	Homo sapiens	172-175
1317072-12	1992	The activities of beta-glucuronidase, acid phosphatase, and alkaline phosphatase were minimal in PMN supernatants when using LPS and PMA as stimuli.	Tetradecanoylphorbol Acetate	133-136	glucuronidase beta	Equus caballus	18-36
1740409-2	1992	TF activity in both monocytes and endothelial cells is regulated by various cytokines and mitogens, including the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	147-178	coagulation factor III, tissue factor	Homo sapiens	0-2
1740409-2	1992	TF activity in both monocytes and endothelial cells is regulated by various cytokines and mitogens, including the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	180-183	coagulation factor III, tissue factor	Homo sapiens	0-2
1740409-4	1992	The cytoplasmic domains of both rat and human TF were rapidly phosphorylated after cells were treated with 10-100 nM PMA.	Tetradecanoylphorbol Acetate	117-120	coagulation factor III, tissue factor	Homo sapiens	46-48
1540207-1	1992	Chemical modifications of Leu-enkephalin by phorbol myristate acetate-stimulated polymorphonuclear leukocytes.	Tetradecanoylphorbol Acetate	44-69	prodynorphin	Homo sapiens	26-40
1540207-2	1992	When L-tyrosyl-glycyl-L-phenylalanyl-L-leucine (Leu-enkephalin) is exposed to the activated oxygen species produced by phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocytes (PMNs), hydroxylation of the phenylalanyl residue in position 4 of the peptide occurs, producing hydroxy-phenylalanyl derivatives which are identified by HPLC analysis and mass spectrometry.	Tetradecanoylphorbol Acetate	119-144	prodynorphin	Homo sapiens	48-62
1540207-2	1992	When L-tyrosyl-glycyl-L-phenylalanyl-L-leucine (Leu-enkephalin) is exposed to the activated oxygen species produced by phorbol myristate acetate (PMA)-stimulated polymorphonuclear leukocytes (PMNs), hydroxylation of the phenylalanyl residue in position 4 of the peptide occurs, producing hydroxy-phenylalanyl derivatives which are identified by HPLC analysis and mass spectrometry.	Tetradecanoylphorbol Acetate	146-149	prodynorphin	Homo sapiens	48-62
1733720-9	1992	Addition of ionomycin or 12-O-tetradecanoyl-phorbol-13-acetate separately to acidified cells had only modest effects on pHi; however, addition of 12-O-tetradecanoyl-phorbol-13-acetate and ionomycin together increased pHi markedly.	Tetradecanoylphorbol Acetate	25-62	glucose-6-phosphate isomerase	Rattus norvegicus	217-220
1733720-9	1992	Addition of ionomycin or 12-O-tetradecanoyl-phorbol-13-acetate separately to acidified cells had only modest effects on pHi; however, addition of 12-O-tetradecanoyl-phorbol-13-acetate and ionomycin together increased pHi markedly.	Tetradecanoylphorbol Acetate	146-183	glucose-6-phosphate isomerase	Rattus norvegicus	217-220
1319513-1	1992	We investigated the effect of phorbol myristate acetate (PMA), dexamethasone (Dex) and reagents which raise intracellular cyclic AMP, on the production of plasminogen activator inhibitor type-2 (PAI-2) in human promyelocytic leukemia cell line, PL-21 and on the production of urinary type plasminogen activator (u-PA) in human pre-B cell lymphoma cell line, RC-K8.	Tetradecanoylphorbol Acetate	30-55	serpin family B member 2	Homo sapiens	155-193
1319513-1	1992	We investigated the effect of phorbol myristate acetate (PMA), dexamethasone (Dex) and reagents which raise intracellular cyclic AMP, on the production of plasminogen activator inhibitor type-2 (PAI-2) in human promyelocytic leukemia cell line, PL-21 and on the production of urinary type plasminogen activator (u-PA) in human pre-B cell lymphoma cell line, RC-K8.	Tetradecanoylphorbol Acetate	30-55	serpin family B member 2	Homo sapiens	195-200
1346232-7	1992	(iii) Addition of a mitogen (namely, phorbol 12-myristate 13-acetate) to serum-starved KRC-7 cells in culture induces an increase of p67 and thus increases protein synthesis.	Tetradecanoylphorbol Acetate	37-68	methionyl aminopeptidase 2	Rattus norvegicus	133-136
1730652-4	1992	A prolonged treatment (18 h) of LAK cells with 12-O-tetradecanoylphorbol-13-acetate resulted in the loss of both PKC and LAK cell activity.	Tetradecanoylphorbol Acetate	47-83	alpha-kinase 1	Mus musculus	32-35
1730652-4	1992	A prolonged treatment (18 h) of LAK cells with 12-O-tetradecanoylphorbol-13-acetate resulted in the loss of both PKC and LAK cell activity.	Tetradecanoylphorbol Acetate	47-83	alpha-kinase 1	Mus musculus	121-124
1733573-7	1992	Chronic treatment of CD-1 murine epidermis with TPA appeared to cause the expansion of an intermediate sized cell subpopulation that was not apparent with EPP or mezerein.	Tetradecanoylphorbol Acetate	48-51	CD1 antigen complex	Mus musculus	21-25
1559263-7	1992	Activation with phorbol-myristate-acetate, which is a strong stimulus for aggregation but produces only a slight release in the granular content, resulted in the association of only a negligible amount of vinculin with the cytoskeletal fraction.	Tetradecanoylphorbol Acetate	16-41	vinculin	Bos taurus	205-213
1733630-7	1992	The accumulation of IL-2R-beta-specific mRNA is observed in freshly isolated thymocytes and it is increased in thymocytes cultured with rIL-2 alone, with Con A, and further enhanced by the addition of rIL-2 in combination with Con A or with TPA.	Tetradecanoylphorbol Acetate	241-244	interleukin 2	Rattus norvegicus	136-141
1733630-7	1992	The accumulation of IL-2R-beta-specific mRNA is observed in freshly isolated thymocytes and it is increased in thymocytes cultured with rIL-2 alone, with Con A, and further enhanced by the addition of rIL-2 in combination with Con A or with TPA.	Tetradecanoylphorbol Acetate	241-244	interleukin 2	Rattus norvegicus	201-206
1555524-0	1992	Dose, time and route dependency of the induction of rat hepatic ornithine decarboxylase by 12-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	91-125	ornithine decarboxylase 1	Rattus norvegicus	64-87
1555524-1	1992	Ornithine decarboxylase (ODC) activity, the rate limiting enzyme in polyamine biosynthesis, was determined after 12-O-tetradecanoylphorbol 13-acetate (TPA) administration to female Sprague-Dawley rats.	Tetradecanoylphorbol Acetate	113-149	ornithine decarboxylase 1	Rattus norvegicus	0-23
1555524-1	1992	Ornithine decarboxylase (ODC) activity, the rate limiting enzyme in polyamine biosynthesis, was determined after 12-O-tetradecanoylphorbol 13-acetate (TPA) administration to female Sprague-Dawley rats.	Tetradecanoylphorbol Acetate	113-149	ornithine decarboxylase 1	Rattus norvegicus	25-28
1555524-1	1992	Ornithine decarboxylase (ODC) activity, the rate limiting enzyme in polyamine biosynthesis, was determined after 12-O-tetradecanoylphorbol 13-acetate (TPA) administration to female Sprague-Dawley rats.	Tetradecanoylphorbol Acetate	151-154	ornithine decarboxylase 1	Rattus norvegicus	0-23
1555524-1	1992	Ornithine decarboxylase (ODC) activity, the rate limiting enzyme in polyamine biosynthesis, was determined after 12-O-tetradecanoylphorbol 13-acetate (TPA) administration to female Sprague-Dawley rats.	Tetradecanoylphorbol Acetate	151-154	ornithine decarboxylase 1	Rattus norvegicus	25-28
1555524-3	1992	The most effective dose for ODC induction by the intraperitoneal route was 40 ug TPA/kg which caused 3-5 fold ODC induction.	Tetradecanoylphorbol Acetate	81-84	ornithine decarboxylase 1	Rattus norvegicus	28-31
1555524-3	1992	The most effective dose for ODC induction by the intraperitoneal route was 40 ug TPA/kg which caused 3-5 fold ODC induction.	Tetradecanoylphorbol Acetate	81-84	ornithine decarboxylase 1	Rattus norvegicus	110-113
1555524-4	1992	Maximal ODC induction occurred in a narrow time band 5 hours after TPA administration.	Tetradecanoylphorbol Acetate	67-70	ornithine decarboxylase 1	Rattus norvegicus	8-11
1740102-5	1992	We report here that the 150 bp region upstream of the first initiation site of RNA transcribed from the murine germ-line C gamma 1 gene, contains promoter and enhancer elements responsible for basal level transcription and inducibility by anti-Ig phorbol myristate acetate (PMA) and for synergy of these inducers with IL-4 in a surface IgM+ B cell line, L10A6.2 and a surface IgG2a+ B cell line, A20.3.	Tetradecanoylphorbol Acetate	247-272	interleukin 4	Mus musculus	318-322
1617227-4	1992	We characterized the early effects of phorbol-12-myristate-13-acetate (TPA) on the attachment and spreading of rat aortic endothelial cells (RAEC) to purified extracellular matrix proteins by analyzing the distribution of fibronectin integrin receptors and the organization of cytoskeleton microfilaments during RAEC spreading on four different extracellular matrix peptides (i.e., Collagen Types I and IV, fibronectin and laminin).	Tetradecanoylphorbol Acetate	38-69	plasminogen activator, tissue type	Rattus norvegicus	71-74
1537597-0	1992	Expression of interleukin-5 and granulocyte-macrophage colony-stimulating factor in human peripheral blood mononuclear cells after activation with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	147-172	colony stimulating factor 2	Homo sapiens	32-80
1371694-3	1992	We now report that four mAbs independently produced against human umbilical vein endothelial cells (HUVECs), chronic myelogenous leukemia in blast crisis, or U-937 pro-monocytic cells stimulated with phorbol myristate acetate also react with endoglin.	Tetradecanoylphorbol Acetate	200-225	endoglin	Homo sapiens	242-250
1284126-9	1992	TPA-mediated stimulation of MMP-1 was similar to that of MMP-3 and MMP-9.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 1	Homo sapiens	28-33
1284126-14	1992	This activity was maximal at 6 h. An association was observed between AP-1 binding activity and increased expression of MMP-1, MMP-3 and MMP-9, which possess TPA-responsive elements (TRE).	Tetradecanoylphorbol Acetate	158-161	matrix metallopeptidase 1	Homo sapiens	120-125
1284126-15	1992	TPA-sensitive MMPs and TIMP-1 were variably stimulated by biologically relevant cytokines, such as IL-1 and TNF-alpha.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 1	Homo sapiens	14-18
1284126-15	1992	TPA-sensitive MMPs and TIMP-1 were variably stimulated by biologically relevant cytokines, such as IL-1 and TNF-alpha.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 alpha	Homo sapiens	99-103
1309813-7	1992	These results indicate that FLG 29.1 cells may represent an osteoclast committed cell population, which upon induction with TPA acquire some morphological, phenotypical, and functional features of differentiated osteoclasts.	Tetradecanoylphorbol Acetate	124-127	filaggrin	Homo sapiens	28-31
1530793-10	1992	In EL-4 cells, IL-1 potentiates PMA-mediated release of IL-2 at suboptimal concentrations of PMA.	Tetradecanoylphorbol Acetate	32-35	interleukin 2	Mus musculus	56-60
1530793-10	1992	In EL-4 cells, IL-1 potentiates PMA-mediated release of IL-2 at suboptimal concentrations of PMA.	Tetradecanoylphorbol Acetate	93-96	interleukin 2	Mus musculus	56-60
1530793-11	1992	Linoleic acid also augmented PMA-induced IL-2 release from the EL-4 cells.	Tetradecanoylphorbol Acetate	29-32	interleukin 2	Mus musculus	41-45
1727435-4	1992	In intact striatal neurons grown in primary culture, the cyclic AMP-increasing drug forskolin and the protein kinase C-activating agent 12-O-tetradecanoylphorbol 13-acetate (TPA) induced a potent phosphorylation of stathmin.	Tetradecanoylphorbol Acetate	136-172	stathmin 1	Homo sapiens	215-223
1727435-4	1992	In intact striatal neurons grown in primary culture, the cyclic AMP-increasing drug forskolin and the protein kinase C-activating agent 12-O-tetradecanoylphorbol 13-acetate (TPA) induced a potent phosphorylation of stathmin.	Tetradecanoylphorbol Acetate	174-177	stathmin 1	Homo sapiens	215-223
1532844-1	1992	We studied changes in the three types of Fc gamma receptor (FcR) on the THP-1 human monocytic leukemia cells, after incubation with the phorbol ester, PMA, which has been shown to alter the expression of several genes in these cells.	Tetradecanoylphorbol Acetate	151-154	Fc gamma receptor Ia	Homo sapiens	41-58
1532844-1	1992	We studied changes in the three types of Fc gamma receptor (FcR) on the THP-1 human monocytic leukemia cells, after incubation with the phorbol ester, PMA, which has been shown to alter the expression of several genes in these cells.	Tetradecanoylphorbol Acetate	151-154	Fc gamma receptor Ia	Homo sapiens	60-63
1532844-7	1992	In order to further delineate the mechanism by which PMA induces alterations in FcR expression, we treated cells with stimulators of protein kinase C, of Ca2+ calmodulin-dependent kinase, and of protein kinase A.	Tetradecanoylphorbol Acetate	53-56	Fc gamma receptor Ia	Homo sapiens	80-83
1564939-2	1992	Phosphorylation of p19 occurs when the growth of cells is affected by 12-O-tetradecanoylphorbol-13-acetate (TPA) and it has been proposed that increased phosphorylation of p19 relates to the cessation of cell growth.	Tetradecanoylphorbol Acetate	70-106	interleukin 23 subunit alpha	Homo sapiens	19-22
1564939-2	1992	Phosphorylation of p19 occurs when the growth of cells is affected by 12-O-tetradecanoylphorbol-13-acetate (TPA) and it has been proposed that increased phosphorylation of p19 relates to the cessation of cell growth.	Tetradecanoylphorbol Acetate	108-111	interleukin 23 subunit alpha	Homo sapiens	19-22
1564939-2	1992	Phosphorylation of p19 occurs when the growth of cells is affected by 12-O-tetradecanoylphorbol-13-acetate (TPA) and it has been proposed that increased phosphorylation of p19 relates to the cessation of cell growth.	Tetradecanoylphorbol Acetate	108-111	interleukin 23 subunit alpha	Homo sapiens	172-175
1564939-4	1992	Changes in the levels of two phosphorylated forms of p19 were assessed in HL-60 promyelocytic cells and a variant HL-60 cell line which stopped growing and differentiated in response to TPA and were compared to changes seen in HL-60 variant lines which merely growth arrested when treated with TPA.	Tetradecanoylphorbol Acetate	186-189	interleukin 23 subunit alpha	Homo sapiens	53-56
1445622-0	1992	12-O-tetradecanoylphorbol-13-acetate--induced levels of AP-1 proteins: a 46-kDa protein immunoprecipitated by anti-fra-1 and induced in promotion-resistant but not promotion-sensitive JB6 cells.	Tetradecanoylphorbol Acetate	0-36	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	115-120
1445622-5	1992	Whereas the AP-1 proteins junB, junD, and fosB did not show differential basal or TPA-inducible levels in P+ and P- cells, a 46-kDa species precipitated by anti-fra-1 antibody was TPA-inducible in P- cells but not in P+ cells, and c-jun protein was present at higher levels in TPA-treated and untreated P+ cells than in P- cells.	Tetradecanoylphorbol Acetate	180-183	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	161-166
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	Tetradecanoylphorbol Acetate	87-90	interleukin 1 alpha	Homo sapiens	144-154
1661292-3	1991	Dibutyryl cAMP, 8-bromo-cAMP, forskolin, cholera toxin, PGE1, and PGE2 synergized with PMA or LPS to increase the accumulation in cell lines of IL-1 alpha mRNA by up to 50-fold and that of IL-1 beta mRNA by 10- to 20-fold compared to LPS or PMA alone.	Tetradecanoylphorbol Acetate	241-244	interleukin 1 alpha	Homo sapiens	144-154
1774959-8	1991	Augmented TPA dependent vector derived c-myc expression was accompanied by enhanced mitogenesis of the cell line FDMT myc.A1 compared with FDC-P1.	Tetradecanoylphorbol Acetate	10-13	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	39-44
1774959-6	1991	However, stable transfection of FDC-P1 with a c-myc expression vector driven by a human methallothionein IIA promoter containing the TPA responsive element (TRE), led to a cell clone, FDMT myc.A1, in which TPA mediated selective transcription of the transfected TRE driven c-myc vector and down-regulated expression of the endogenous c-myc gene.	Tetradecanoylphorbol Acetate	206-209	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	46-51
1774959-9	1991	In addition, TPA mediated expression of the transfected c-myc gene in FDMT myc.A1 was accompanied by augmented transcription of c-jun and c-fos in response to TPA.	Tetradecanoylphorbol Acetate	13-16	FBJ osteosarcoma oncogene	Mus musculus	138-143
1774959-9	1991	In addition, TPA mediated expression of the transfected c-myc gene in FDMT myc.A1 was accompanied by augmented transcription of c-jun and c-fos in response to TPA.	Tetradecanoylphorbol Acetate	159-162	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	56-61
1774959-9	1991	In addition, TPA mediated expression of the transfected c-myc gene in FDMT myc.A1 was accompanied by augmented transcription of c-jun and c-fos in response to TPA.	Tetradecanoylphorbol Acetate	159-162	FBJ osteosarcoma oncogene	Mus musculus	138-143
1819706-4	1991	Paf, from 1 x 10(-5) M to 10(-6) M, decreased B cell proliferation induced by both phorbol myristate acetate (PMA) and anti-IgM antibodies (anti-IgM Ab).	Tetradecanoylphorbol Acetate	83-108	PCNA clamp associated factor	Homo sapiens	0-3
1819706-4	1991	Paf, from 1 x 10(-5) M to 10(-6) M, decreased B cell proliferation induced by both phorbol myristate acetate (PMA) and anti-IgM antibodies (anti-IgM Ab).	Tetradecanoylphorbol Acetate	110-113	PCNA clamp associated factor	Homo sapiens	0-3
1812965-6	1991	Chimeric molecules bearing the cytoplasmic domain of CD4 and the extracellular domain of either the low-density lipoprotein receptor or a major histocompatibility complex (MHC) class I molecule were both internalized in response to phorbol 12-myristate 13-acetate and were subsequently degraded, indicating that the cytoplasmic tail of CD4 contains all the information required for both processes.	Tetradecanoylphorbol Acetate	232-263	low density lipoprotein receptor	Homo sapiens	100-132
1658006-7	1991	In addition, fucoidan-induced uPA activity was detected in conditioned media in as little as 15 min, whereas PMA-induced uPA activity did not increase until 2 h. In addition to stimulating macrophage secretion of uPA, fucoidan bound uPA and had a small stimulatory affect on uPA activity.	Tetradecanoylphorbol Acetate	109-112	plasminogen activator, urokinase	Mus musculus	121-124
1658006-7	1991	In addition, fucoidan-induced uPA activity was detected in conditioned media in as little as 15 min, whereas PMA-induced uPA activity did not increase until 2 h. In addition to stimulating macrophage secretion of uPA, fucoidan bound uPA and had a small stimulatory affect on uPA activity.	Tetradecanoylphorbol Acetate	109-112	plasminogen activator, urokinase	Mus musculus	121-124
1658006-7	1991	In addition, fucoidan-induced uPA activity was detected in conditioned media in as little as 15 min, whereas PMA-induced uPA activity did not increase until 2 h. In addition to stimulating macrophage secretion of uPA, fucoidan bound uPA and had a small stimulatory affect on uPA activity.	Tetradecanoylphorbol Acetate	109-112	plasminogen activator, urokinase	Mus musculus	121-124
1658006-7	1991	In addition, fucoidan-induced uPA activity was detected in conditioned media in as little as 15 min, whereas PMA-induced uPA activity did not increase until 2 h. In addition to stimulating macrophage secretion of uPA, fucoidan bound uPA and had a small stimulatory affect on uPA activity.	Tetradecanoylphorbol Acetate	109-112	plasminogen activator, urokinase	Mus musculus	121-124
1742331-2	1991	In normal B lymphocytes and lymphocytes from five patients with B-CLL, TPA stimulation increased lymphocyte fructose 2,6-bisphosphate (fructose 2,6-P2) content and activity of 6-phosphofructo 2-kinase (PFK-2), which is the enzyme that catalyzes the synthesis of fructose 2,6-P2.	Tetradecanoylphorbol Acetate	71-74	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	202-207
1742333-0	1991	Modulation of synovial fibroblast plasminogen activator and plasminogen activator inhibitor production by protein kinase C. Phorbol myristate acetate (PMA) added to human synovial fibroblast cultures caused a dose-dependent increase in the production of plasminogen activator inhibitor-type 1 (PAI-1).	Tetradecanoylphorbol Acetate	124-149	serpin family E member 1	Homo sapiens	254-292
1742333-0	1991	Modulation of synovial fibroblast plasminogen activator and plasminogen activator inhibitor production by protein kinase C. Phorbol myristate acetate (PMA) added to human synovial fibroblast cultures caused a dose-dependent increase in the production of plasminogen activator inhibitor-type 1 (PAI-1).	Tetradecanoylphorbol Acetate	124-149	serpin family E member 1	Homo sapiens	294-299
1742333-0	1991	Modulation of synovial fibroblast plasminogen activator and plasminogen activator inhibitor production by protein kinase C. Phorbol myristate acetate (PMA) added to human synovial fibroblast cultures caused a dose-dependent increase in the production of plasminogen activator inhibitor-type 1 (PAI-1).	Tetradecanoylphorbol Acetate	151-154	serpin family E member 1	Homo sapiens	254-292
1742333-0	1991	Modulation of synovial fibroblast plasminogen activator and plasminogen activator inhibitor production by protein kinase C. Phorbol myristate acetate (PMA) added to human synovial fibroblast cultures caused a dose-dependent increase in the production of plasminogen activator inhibitor-type 1 (PAI-1).	Tetradecanoylphorbol Acetate	151-154	serpin family E member 1	Homo sapiens	294-299
1742333-1	1991	In addition, PMA inhibited endogenous and interleukin-1 (IL-1) induced plasminogen activator (PA) activity, while increasing mRNA PAI-1 levels.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 alpha	Homo sapiens	42-55
1742333-1	1991	In addition, PMA inhibited endogenous and interleukin-1 (IL-1) induced plasminogen activator (PA) activity, while increasing mRNA PAI-1 levels.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 alpha	Homo sapiens	57-61
1742333-1	1991	In addition, PMA inhibited endogenous and interleukin-1 (IL-1) induced plasminogen activator (PA) activity, while increasing mRNA PAI-1 levels.	Tetradecanoylphorbol Acetate	13-16	serpin family E member 1	Homo sapiens	130-135
1657576-12	1991	Treatment of pituitary cell cultures with PMA (8-16 h) also stimulated the synthesis of GnRH receptors, although to a lesser extent than that observed after GnRH treatment.	Tetradecanoylphorbol Acetate	42-45	gonadotropin releasing hormone 1	Rattus norvegicus	88-92
1717079-3	1991	However, expression of TF can be induced in these cells in response to stimulation by diverse inflammatory mediators such as interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), lipopolysaccharide (LPS), and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	228-259	coagulation factor III, tissue factor	Homo sapiens	23-25
1717079-3	1991	However, expression of TF can be induced in these cells in response to stimulation by diverse inflammatory mediators such as interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), lipopolysaccharide (LPS), and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	261-264	coagulation factor III, tissue factor	Homo sapiens	23-25
1725834-5	1991	Concentrations of free plasminogen activator inhibitor (PAI-1) and complex of tPA-PAI-1 decreased from 8:30 to 16:30.	Tetradecanoylphorbol Acetate	78-81	serpin family E member 1	Homo sapiens	82-87
1655758-5	1991	In contrast, under the same experimental conditions PMA treatment blocked completely the PAF-induced inositol phosphates formation in cells prelabeled with [3H]inositol.	Tetradecanoylphorbol Acetate	52-55	PCNA clamp associated factor	Homo sapiens	89-92
1655758-6	1991	Thus, PMA treatment demonstrates that phospholipase D activation can occur independently from phosphoinositide-specific phospholipase C activation during PAF stimulation in U937 cells.	Tetradecanoylphorbol Acetate	6-9	PCNA clamp associated factor	Homo sapiens	154-157
1909967-8	1991	The serum-induced expression of c-fos gene was abolished by DMSO treatment of MEF while the phorbol 12-myristate 13-acetate-induced expression of fos gene was not, indicating that the PMA signaling pathway was refractory to DMSO.	Tetradecanoylphorbol Acetate	184-187	FBJ osteosarcoma oncogene	Mus musculus	32-37
1909967-8	1991	The serum-induced expression of c-fos gene was abolished by DMSO treatment of MEF while the phorbol 12-myristate 13-acetate-induced expression of fos gene was not, indicating that the PMA signaling pathway was refractory to DMSO.	Tetradecanoylphorbol Acetate	184-187	FBJ osteosarcoma oncogene	Mus musculus	34-37
1939341-3	1991	These findings were associated with a block in appearance of the monocytic phenotype, including inhibition of TPA-induced increases in lamin A, lamin C, and vimentin transcripts.	Tetradecanoylphorbol Acetate	110-113	vimentin	Homo sapiens	157-165
1723145-4	1991	A maximally effective dose of PMA (1 microM) caused decreases in TRH-R mRNA that were similar in magnitude and time course to those induced by 1 microM TRH.	Tetradecanoylphorbol Acetate	30-33	thyrotropin releasing hormone receptor	Rattus norvegicus	65-70
1661435-1	1991	Interstitial collagenase either obtained from human neutrophils by phorbol myristate acetate (PMA) induced degranulation or isolated from human gingival crevicular fluid was found to be activated by addition of an oxidative agent, hypochlorous acid (HOCl).	Tetradecanoylphorbol Acetate	67-92	matrix metallopeptidase 1	Homo sapiens	0-24
1661435-1	1991	Interstitial collagenase either obtained from human neutrophils by phorbol myristate acetate (PMA) induced degranulation or isolated from human gingival crevicular fluid was found to be activated by addition of an oxidative agent, hypochlorous acid (HOCl).	Tetradecanoylphorbol Acetate	94-97	matrix metallopeptidase 1	Homo sapiens	0-24
1930203-4	1991	Moreover treatment of HL-60 promyelocytic leukemia cells with DMSO or PMA which induced terminal differentiation resulted in a decrease in the level of Op18 RNA and protein.	Tetradecanoylphorbol Acetate	70-73	stathmin 1	Homo sapiens	152-156
2169292-3	1990	Downmodulation of EGF receptors by 12-O-tetradecanoylphorbol 13-acetate (TPA) is also observed.	Tetradecanoylphorbol Acetate	35-71	epidermal growth factor	Homo sapiens	18-21
2169292-3	1990	Downmodulation of EGF receptors by 12-O-tetradecanoylphorbol 13-acetate (TPA) is also observed.	Tetradecanoylphorbol Acetate	73-76	epidermal growth factor	Homo sapiens	18-21
2092039-7	1990	The presence of IL-2 in the supernatants of splenocytes from GM-1/P (1mg/Kg, i.v., ,day-1) treated mice stimulated with Con A or Con A plus TPA for 48 hrs was evaluated by proliferation of an IL-2 dependent CTLL cell line.	Tetradecanoylphorbol Acetate	140-143	interleukin 2	Mus musculus	16-20
2092039-8	1990	GM-1/P by itself was unable to stimulate IL-2 production; however it markedly increased IL-2 production induced by Con A or Con A plus TPA.	Tetradecanoylphorbol Acetate	135-138	interleukin 2	Mus musculus	88-92
1966814-3	1990	Although a relatively weak direct oxidative agonist, PAF markedly enhances O2- release evoked by phorbol myristate acetate (PMA) and the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP), increasing the maximal rate of O2- production by a calcium-dependent mechanism.	Tetradecanoylphorbol Acetate	97-122	PCNA clamp associated factor	Homo sapiens	53-56
1966814-3	1990	Although a relatively weak direct oxidative agonist, PAF markedly enhances O2- release evoked by phorbol myristate acetate (PMA) and the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP), increasing the maximal rate of O2- production by a calcium-dependent mechanism.	Tetradecanoylphorbol Acetate	124-127	PCNA clamp associated factor	Homo sapiens	53-56
2153304-7	1990	Phorbol 12-myristate 13-acetate, bryostatin-1, and 1,2-dioctanoylglycerol were found to induce rapid down-regulation of the GM-CSF receptor in neutrophils, monocytes, and partially purified myeloid progenitor cells, suggesting that this effect may be at least partially mediated by protein kinase C. These data suggest that certain activators of neutrophil function may negatively regulate their biological effects by inducing down-regulation of the GM-CSF receptor.	Tetradecanoylphorbol Acetate	0-31	colony stimulating factor 2	Homo sapiens	124-130
2153304-7	1990	Phorbol 12-myristate 13-acetate, bryostatin-1, and 1,2-dioctanoylglycerol were found to induce rapid down-regulation of the GM-CSF receptor in neutrophils, monocytes, and partially purified myeloid progenitor cells, suggesting that this effect may be at least partially mediated by protein kinase C. These data suggest that certain activators of neutrophil function may negatively regulate their biological effects by inducing down-regulation of the GM-CSF receptor.	Tetradecanoylphorbol Acetate	0-31	colony stimulating factor 2	Homo sapiens	450-456
33801658-7	2021	RESULTS: The two sphingosine-1-phosphate receptors (S1PRs) expressed in peritoneal B cell subsets S1P1 and S1P4 are differentially regulated upon stimulation with the TLR4 agonist LPS, but not upon PMA/ionomycin or B cell receptor (BCR) crosslinking.	Tetradecanoylphorbol Acetate	198-201	toll like receptor 4	Homo sapiens	167-171
33237422-8	2021	PMA induced the MAPK pathway in HeLa cells through the activation of ERK, CREB, and RSK1.	Tetradecanoylphorbol Acetate	0-3	ribosomal protein S6 kinase A1	Homo sapiens	84-88
33824670-11	2020	There was a modest increase in PPARalpha activity at low concentration of tPA.	Tetradecanoylphorbol Acetate	74-77	peroxisome proliferator activated receptor alpha	Homo sapiens	31-40
32140039-0	2020	Eupatilin downregulates phorbol 12-myristate 13-acetate-induced MUC5AC expression via inhibition of p38/ERK/JNK MAPKs signal pathway in human airway epithelial cells.	Tetradecanoylphorbol Acetate	24-55	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	64-70
32140039-4	2020	In the present study, we investigated the effect of eupatilin on phorbol 12-myristate 13-acetate (PMA)-induced MUC5AC and MUC5B expression in human airway epithelial cells.	Tetradecanoylphorbol Acetate	65-96	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	111-117
32140039-4	2020	In the present study, we investigated the effect of eupatilin on phorbol 12-myristate 13-acetate (PMA)-induced MUC5AC and MUC5B expression in human airway epithelial cells.	Tetradecanoylphorbol Acetate	98-101	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	111-117
19577457-3	2010	Among these compounds diversin (IC(50): 7.7) exhibited the strongest inhibitory effect and was selected to examine its effects on in vivo two-stage mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) as initiator and TPA as promoter.	Tetradecanoylphorbol Acetate	240-243	ankyrin repeat domain 6	Mus musculus	22-30
12754413-6	2003	In PMA- treated cells, the level of hOGG1 protein was lowered, even though the DNA nicking activity was elevated, in a manner similar to the changes in serum- deprived HL-60 cells.	Tetradecanoylphorbol Acetate	3-6	8-oxoguanine DNA glycosylase	Homo sapiens	36-41
34735035-4	2022	By encapsulating the pyridinium hemicyanine dye DSM with a large two-photon absorption (TPA) cross-section in NIR-II window into the porphyrin-based HOF, the resultant DSM@n-HOF-6 exhibits significant two-photon NIR-II-excited Fluorescence Resonance Energy Transfer (FRET) to generate singlet oxygen ( 1 O 2 ) for Abeta oxidation.	Tetradecanoylphorbol Acetate	88-91	amyloid beta (A4) precursor protein	Mus musculus	314-319
34619426-8	2021	RESULTS: Stimulations of whole blood and spleen samples with phorbol 12-myristate 13-acetate/ionomycin (PMA/I) at post-injury day 1 were associated with significant decreases in IFN-gamma-positive cells/million in injured animals.	Tetradecanoylphorbol Acetate	61-92	interferon gamma	Rattus norvegicus	178-187
34619426-8	2021	RESULTS: Stimulations of whole blood and spleen samples with phorbol 12-myristate 13-acetate/ionomycin (PMA/I) at post-injury day 1 were associated with significant decreases in IFN-gamma-positive cells/million in injured animals.	Tetradecanoylphorbol Acetate	104-107	interferon gamma	Rattus norvegicus	178-187
34592416-5	2021	The PMA-treated S1P2knockout THP-1 Mphis showed decreases in IL-4/IL-13-induced phosphorylation of Janus-activated kinase (JAK) 1, JAK2, and STAT6 as well as mRNA expression of the M2 marker ARG1 compared with wild-type THP-1 Mphis.	Tetradecanoylphorbol Acetate	4-7	signal transducer and activator of transcription 6	Homo sapiens	141-146
34592416-6	2021	Pretreatment of PMA-treated THP-1 Mphis with the S1P2 antagonist JTE-013, the Rho inhibitor Rhosin or the Rho kinase inhibitor Y27632 inhibited the IL-4/IL-13-induced increase in STAT6 phosphorylation.	Tetradecanoylphorbol Acetate	16-19	sphingosine-1-phosphate receptor 2	Homo sapiens	49-53
34592416-6	2021	Pretreatment of PMA-treated THP-1 Mphis with the S1P2 antagonist JTE-013, the Rho inhibitor Rhosin or the Rho kinase inhibitor Y27632 inhibited the IL-4/IL-13-induced increase in STAT6 phosphorylation.	Tetradecanoylphorbol Acetate	16-19	signal transducer and activator of transcription 6	Homo sapiens	179-184
34645824-0	2021	Phorbol-12-myristate 13-acetate inhibits Nephronectin gene expression via Protein kinase C alpha and c-Jun/c-Fos transcription factors.	Tetradecanoylphorbol Acetate	0-31	nephronectin	Mus musculus	41-53
34645824-0	2021	Phorbol-12-myristate 13-acetate inhibits Nephronectin gene expression via Protein kinase C alpha and c-Jun/c-Fos transcription factors.	Tetradecanoylphorbol Acetate	0-31	FBJ osteosarcoma oncogene	Mus musculus	107-112
34645824-2	2021	A search for factors that regulate Npnt gene expression in osteoblasts revealed that phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), had a strong effect to suppress that expression.	Tetradecanoylphorbol Acetate	85-116	nephronectin	Mus musculus	35-39
34645824-2	2021	A search for factors that regulate Npnt gene expression in osteoblasts revealed that phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), had a strong effect to suppress that expression.	Tetradecanoylphorbol Acetate	118-121	nephronectin	Mus musculus	35-39
34671340-5	2021	As a functional outcome, immobilized FH and FHR-1 inhibited PMA-induced NET formation, but increased the adherence and IL-8 production of neutrophils.	Tetradecanoylphorbol Acetate	60-63	complement factor H related 1	Homo sapiens	44-49
34439220-4	2021	Upon treatment with lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA), LNX1 expression levels increased.	Tetradecanoylphorbol Acetate	49-80	ligand of numb-protein X 1	Homo sapiens	88-92
34439220-4	2021	Upon treatment with lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA), LNX1 expression levels increased.	Tetradecanoylphorbol Acetate	82-85	ligand of numb-protein X 1	Homo sapiens	88-92
34422811-0	2021	Study of lncRNA TPA in Promoting Invasion and Metastasis of Breast Cancer Mediated by TGF-beta Signaling Pathway.	Tetradecanoylphorbol Acetate	16-19	transforming growth factor alpha	Mus musculus	86-94
34422811-7	2021	Results: Overexpression of lncRNA TPA decreased the expression of E-cadherin, and significantly increased the expression of Vimentin, fibronectin and TGF-beta1 (p < 0.01), and increased the migration rate, migration ability and invasion ability of cell group (P < 0.01).	Tetradecanoylphorbol Acetate	34-37	fibronectin 1	Mus musculus	134-145
34422811-9	2021	Conclusion: LncRNA TPA affects the occurrence of breast cancer EMT through TGF-beta signaling pathway, and then promotes the invasion and metastasis of breast cancer.	Tetradecanoylphorbol Acetate	19-22	transforming growth factor alpha	Mus musculus	75-83
34249397-9	2021	However, CBD treatment has no changes in gene expression including beta-catenin, but the decreased beta-catenin expression by testosterone or PMA was restored by CBD pretreatment, suggesting that potential regulatory effect on alopecia induction of testosterone and PMA.	Tetradecanoylphorbol Acetate	142-145	catenin beta 1	Homo sapiens	99-111
34249397-9	2021	However, CBD treatment has no changes in gene expression including beta-catenin, but the decreased beta-catenin expression by testosterone or PMA was restored by CBD pretreatment, suggesting that potential regulatory effect on alopecia induction of testosterone and PMA.	Tetradecanoylphorbol Acetate	266-269	catenin beta 1	Homo sapiens	99-111
34248948-6	2021	Furthermore, a Syk inhibitor attenuated NETs, that activated by phorbol myristate acetate (PMA; a NETs activator) or lipopolysaccharide (LPS; a potent inflammatory stimulator), more prominently in Fcgr2b-/- neutrophils than the WT cells as determined by dsDNA, PAD4 and MPO.	Tetradecanoylphorbol Acetate	64-89	MMTV LTR integration site 4	Mus musculus	261-265
35489137-5	2022	For in vitro experiments, SphK1 in human SH-SY5Y neuroblastoma cells was activated using SphK1-specific activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	114-145	sphingosine kinase 1	Homo sapiens	26-31
35489137-5	2022	For in vitro experiments, SphK1 in human SH-SY5Y neuroblastoma cells was activated using SphK1-specific activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	114-145	sphingosine kinase 1	Homo sapiens	89-94
35489137-5	2022	For in vitro experiments, SphK1 in human SH-SY5Y neuroblastoma cells was activated using SphK1-specific activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	147-150	sphingosine kinase 1	Homo sapiens	26-31
35489137-5	2022	For in vitro experiments, SphK1 in human SH-SY5Y neuroblastoma cells was activated using SphK1-specific activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	147-150	sphingosine kinase 1	Homo sapiens	89-94
35594938-4	2022	Moreover, cytokine secretion assays also presented that DDP-1 can promote cytokine production of TNF-alpha and IL-6 in THP-1 macrophage stimulated by PMA.	Tetradecanoylphorbol Acetate	150-153	translocase of inner mitochondrial membrane 8A	Homo sapiens	56-61
35513847-9	2022	PBMCs produced high levels of IFN-gamma, IL-4, and IL-17A after stimulation with PMA/Ionomycin and Con A.	Tetradecanoylphorbol Acetate	81-84	interferon gamma	Ovis aries	30-39
35612375-4	2022	In this study, we found that pro-inflammatory cytokines-IL-1beta, IL-6 and TNFalpha showed greater induction in phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells than in THP-1 cells.	Tetradecanoylphorbol Acetate	112-143	interleukin 1 alpha	Homo sapiens	56-64
35612375-4	2022	In this study, we found that pro-inflammatory cytokines-IL-1beta, IL-6 and TNFalpha showed greater induction in phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells than in THP-1 cells.	Tetradecanoylphorbol Acetate	145-148	interleukin 1 alpha	Homo sapiens	56-64
35123783-9	2022	The BHB treatment with or without PMA treatment decreased protein abundance of Cit-H3 and PAD4 (arginine deiminase 4) and increased neutrophil elastase.	Tetradecanoylphorbol Acetate	34-37	elastase, neutrophil expressed	Bos taurus	132-151
35222701-9	2022	PMA treatment inhibited the proliferation of LPS-induced hPDLSCs transfected with Ov-HMBOX1, which was reversed by transfection with si-CXCL10.	Tetradecanoylphorbol Acetate	0-3	homeobox containing 1	Homo sapiens	85-91
35401828-4	2022	Furthermore, conditional PINCH-1 knockout mouse and carcinogen (7, 12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA))-induced skin cancer model were employed to determine the function of PINCH-1 in regulation of IGF-1R expression and skin carcinogenesis in vivo.	Tetradecanoylphorbol Acetate	141-144	LIM and senescent cell antigen-like domains 1	Mus musculus	216-223
35401828-9	2022	Using a mouse model of DMBA/TPA-induced skin cancer, we show that the levels of both PINCH-1 and IGF-1R were significantly increased in response to treatment with the carcinogens.	Tetradecanoylphorbol Acetate	28-31	LIM and senescent cell antigen-like domains 1	Mus musculus	85-92
35140721-6	2022	Moreover, the 3D culture system was more suitable for the observation of neutrophil extracellular traps (NETs) stimulated by the classical stimulation phorbol ester (PMA), and other damage associated molecular patterns (DAMPs) such as Lipopolysaccharide (LPS)/ATP, interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha) than the 2D culture system.	Tetradecanoylphorbol Acetate	166-169	interleukin 1 alpha	Homo sapiens	285-293
2557227-7	1989	Both alpha- and beta-adrenergic agonists and the tumor promoter 12-O-tetradecanoylphorbol-13-acetate caused a rapid, transient increase in the steady-state level of c-fos mRNA.	Tetradecanoylphorbol Acetate	64-100	FBJ osteosarcoma oncogene	Mus musculus	165-170
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Tetradecanoylphorbol Acetate	136-139	fibronectin 1	Rattus norvegicus	62-73
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Tetradecanoylphorbol Acetate	136-139	fibronectin 1	Rattus norvegicus	186-197
2685108-6	1989	TPA and TGF-beta act both as inducers and inhibitors of NEC1 secretion, depending on the target cell.	Tetradecanoylphorbol Acetate	0-3	proprotein convertase subtilisin/kexin type 1	Homo sapiens	56-60
2530225-0	1989	Phosphorylation of the major leukocyte surface sialoglycoprotein, leukosialin, is increased by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	95-126	LOC105369247	Homo sapiens	66-77
2553162-1	1989	Recombinant human granulocyte colony-stimulating factor (rhG-CSF) enhanced superoxide release and membrane depolarization in parallel in human granulocytes stimulated by the receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine and wheat germ agglutinin, but not by the Ca2+ ionophore ionomycin and phorbol myristate acetate, which bypass the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	313-338	colony stimulating factor 3	Homo sapiens	18-55
2553162-1	1989	Recombinant human granulocyte colony-stimulating factor (rhG-CSF) enhanced superoxide release and membrane depolarization in parallel in human granulocytes stimulated by the receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine and wheat germ agglutinin, but not by the Ca2+ ionophore ionomycin and phorbol myristate acetate, which bypass the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	313-338	colony stimulating factor 2	Homo sapiens	61-64
2478302-6	1989	The requirement for TcR crosslinking in triggering both secretion of granules and secretion of IFN from CTL was pharmacologically reproduced by the synergistic action of PMA, a protein kinase C activator, and the Ca2+ ionophore A23187.	Tetradecanoylphorbol Acetate	170-173	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	20-23
2790819-3	1989	We report here that pretreatment of CD-1 mice with resiniferatoxin blocked the early (3 h) erythema and edema (6 h) in response to phorbol 12-myristate 13-acetate (PMA), whereas the edema at later times (12-24 h) was only partially blocked.	Tetradecanoylphorbol Acetate	131-162	CD1 antigen complex	Mus musculus	36-40
2790819-3	1989	We report here that pretreatment of CD-1 mice with resiniferatoxin blocked the early (3 h) erythema and edema (6 h) in response to phorbol 12-myristate 13-acetate (PMA), whereas the edema at later times (12-24 h) was only partially blocked.	Tetradecanoylphorbol Acetate	164-167	CD1 antigen complex	Mus musculus	36-40
2531721-3	1989	TPA reduces the level of expression of CD20, CD21, mIg and CD45RA and increases CD45RO binding, thereby minimizing the phenotypic heterogeneity of the CLL clones and causing them to converge towards one end of the natural range.	Tetradecanoylphorbol Acetate	0-3	chemokine (C-X-C motif) ligand 9	Mus musculus	51-54
2513479-1	1989	The zif268 gene, which encodes a protein with three typical zinc finger sequences, is induced in mouse 3T3 cells by serum, phorbol 12-myristate 13-acetate platelet-derived growth factor, and fibroblast growth factor.	Tetradecanoylphorbol Acetate	123-154	early growth response 1	Mus musculus	4-10
2676015-5	1989	On stimulation of BMCs with phorbol myristate acetate (PMA) and phytohemagglutinin or PMA and the calcium ionophore ionomycin, approximately 5% expressed GM-CSF mRNA and approximately 1% IL-3 mRNA.	Tetradecanoylphorbol Acetate	28-53	interleukin 3	Homo sapiens	187-191
2676015-5	1989	On stimulation of BMCs with phorbol myristate acetate (PMA) and phytohemagglutinin or PMA and the calcium ionophore ionomycin, approximately 5% expressed GM-CSF mRNA and approximately 1% IL-3 mRNA.	Tetradecanoylphorbol Acetate	55-58	colony stimulating factor 2	Homo sapiens	154-160
2676015-5	1989	On stimulation of BMCs with phorbol myristate acetate (PMA) and phytohemagglutinin or PMA and the calcium ionophore ionomycin, approximately 5% expressed GM-CSF mRNA and approximately 1% IL-3 mRNA.	Tetradecanoylphorbol Acetate	55-58	interleukin 3	Homo sapiens	187-191
2797820-0	1989	Characterization of TIS7, a gene induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	82-111	interferon-related developmental regulator 1	Mus musculus	20-24
2675833-1	1989	In neonatal rat islet cells prelabelled with [14C-methyl] choline, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate rapidly activated a phospholipase D-like mechanism as suggested by the accumulation in cells and medium of choline (but not of phosphorylcholine or glycerophosphorylcholine, markers for phospholipase C and phospholipase A2 action on phosphatidylcholine).	Tetradecanoylphorbol Acetate	85-121	phospholipase A2 group IB	Rattus norvegicus	328-344
2551205-11	1989	We conclude that repeated exposure of rabbits to PMA results in lung injury manifested as depressed pulmonary ACE activity and pulmonary artery hypertension.	Tetradecanoylphorbol Acetate	49-52	angiotensin-converting enzyme	Oryctolagus cuniculus	110-113
2668657-2	1989	The NFS/N1.H7 cell line was strictly dependent upon IL-3 for growth, and the cell line could be activated by phorbol esters (PMA) to augment IL-3 dependent proliferation, but when pKC was downregulated, diminished IL-3 proliferative response resulted.	Tetradecanoylphorbol Acetate	125-128	interleukin 3	Homo sapiens	141-145
2668657-2	1989	The NFS/N1.H7 cell line was strictly dependent upon IL-3 for growth, and the cell line could be activated by phorbol esters (PMA) to augment IL-3 dependent proliferation, but when pKC was downregulated, diminished IL-3 proliferative response resulted.	Tetradecanoylphorbol Acetate	125-128	interleukin 3	Homo sapiens	141-145
2547385-3	1989	Phorbol myristate acetate (PMA) appeared to attenuate PAF- but not FMLP-induced arachidonate metabolism.	Tetradecanoylphorbol Acetate	0-25	PCNA clamp associated factor	Homo sapiens	54-57
2547385-3	1989	Phorbol myristate acetate (PMA) appeared to attenuate PAF- but not FMLP-induced arachidonate metabolism.	Tetradecanoylphorbol Acetate	27-30	PCNA clamp associated factor	Homo sapiens	54-57
1655537-3	1991	This TPA-induced activity induces the threonine and tyrosine phosphorylation of p42 in extracts from unstimulated cells.	Tetradecanoylphorbol Acetate	5-8	cyclin dependent kinase 20	Homo sapiens	80-83
1655729-2	1991	We report that the protein kinase C activating phorbol ester, phorbol 12-myristate-13-acetate (PMA), causes a different induction of the two PAI-1 mRNA species in the human hepatoma cell line, HepG2.	Tetradecanoylphorbol Acetate	62-93	serpin family E member 1	Homo sapiens	141-146
1655729-2	1991	We report that the protein kinase C activating phorbol ester, phorbol 12-myristate-13-acetate (PMA), causes a different induction of the two PAI-1 mRNA species in the human hepatoma cell line, HepG2.	Tetradecanoylphorbol Acetate	95-98	serpin family E member 1	Homo sapiens	141-146
1917916-2	1991	Pretreatment of intact retinas with phorbol myristate acetate markedly increased the light-dependent phosphorylation of rhodopsin, with the greatest effects observed at lower light levels.	Tetradecanoylphorbol Acetate	36-61	rhodopsin	Bos taurus	120-129
1917916-3	1991	Phorbol myristate acetate treatment did not affect rhodopsin phosphorylation in retinas not exposed to light, suggesting that protein kinase C modulates the phosphorylation state of rhodopsin in a light-dependent manner.	Tetradecanoylphorbol Acetate	0-25	rhodopsin	Bos taurus	182-191
1714585-5	1991	Furthermore, thapsigargin could synergize with the tumor promoter phorbol 12-myristate 13-acetate to induce c-fos but not c-jun.	Tetradecanoylphorbol Acetate	66-97	FBJ osteosarcoma oncogene	Mus musculus	108-113
8152801-2	1994	We examined c-ski expression in four different myeloid cell lines which can be induced to differentiate by exposure to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	152-155	SKI proto-oncogene	Gallus gallus	12-17
2545809-1	1989	Granulocyte-macrophage colony-stimulating factor, GM-CSF, potentiates superoxide generation produced by human neutrophils stimulated with fMet-Leu-Phe and platelet-activating factor, PAF, but not by phorbol 12-myristate 13-acetate (PMA) or opsonized zymosan.	Tetradecanoylphorbol Acetate	199-230	colony stimulating factor 2	Homo sapiens	50-56
2545809-1	1989	Granulocyte-macrophage colony-stimulating factor, GM-CSF, potentiates superoxide generation produced by human neutrophils stimulated with fMet-Leu-Phe and platelet-activating factor, PAF, but not by phorbol 12-myristate 13-acetate (PMA) or opsonized zymosan.	Tetradecanoylphorbol Acetate	232-235	colony stimulating factor 2	Homo sapiens	0-48
2545809-1	1989	Granulocyte-macrophage colony-stimulating factor, GM-CSF, potentiates superoxide generation produced by human neutrophils stimulated with fMet-Leu-Phe and platelet-activating factor, PAF, but not by phorbol 12-myristate 13-acetate (PMA) or opsonized zymosan.	Tetradecanoylphorbol Acetate	232-235	colony stimulating factor 2	Homo sapiens	50-56
1654833-1	1991	We obtained a Ca(2+)-independent but 12-O-tetradecanoyl phorbol ester (TPA).phospholipid-activated protein kinase from rat embryo fibroblast 3Y1 cells by succeeding steps of DEAE-cellulose, H-9 affinity, and hydroxylapatite chromatography.	Tetradecanoylphorbol Acetate	71-74	G protein-coupled receptor 50	Rattus norvegicus	174-193
8166683-2	1994	It was found that the extent of TPA-induced phosphorylation of MARCKS was not significantly different between young and old IMR-90 fibroblasts.	Tetradecanoylphorbol Acetate	32-35	myristoylated alanine rich protein kinase C substrate	Homo sapiens	63-69
2500450-4	1989	Maximal amounts of PAI-1 mRNA and secretion of PAI-1 polypeptides were observed after 24 hr of TPA treatment and PAI-1 persisted at elevated levels for several days.	Tetradecanoylphorbol Acetate	95-98	serpin family E member 1	Homo sapiens	47-52
8157661-0	1994	Interleukin 1 alpha mediates collagenase synthesis stimulated by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	65-96	interleukin-1 alpha	Oryctolagus cuniculus	0-19
2684368-2	1989	Adult T-cell Leukemia cell lines MT-1, MT-2, KH-2 and MT-2 stimulated by phorbol 12-myristate 13-acetate (PMA) were used as target cells in immunofluorescence microscopy (IF) examination with positive rates as 0.20% (2/965), 0.62% (6/965), 0.20% (2/965) and 0.51 (5/965) respectively.	Tetradecanoylphorbol Acetate	73-104	metallothionein 2A	Homo sapiens	39-43
2684368-2	1989	Adult T-cell Leukemia cell lines MT-1, MT-2, KH-2 and MT-2 stimulated by phorbol 12-myristate 13-acetate (PMA) were used as target cells in immunofluorescence microscopy (IF) examination with positive rates as 0.20% (2/965), 0.62% (6/965), 0.20% (2/965) and 0.51 (5/965) respectively.	Tetradecanoylphorbol Acetate	73-104	metallothionein 2A	Homo sapiens	54-58
2684368-2	1989	Adult T-cell Leukemia cell lines MT-1, MT-2, KH-2 and MT-2 stimulated by phorbol 12-myristate 13-acetate (PMA) were used as target cells in immunofluorescence microscopy (IF) examination with positive rates as 0.20% (2/965), 0.62% (6/965), 0.20% (2/965) and 0.51 (5/965) respectively.	Tetradecanoylphorbol Acetate	106-109	metallothionein 2A	Homo sapiens	39-43
2684368-2	1989	Adult T-cell Leukemia cell lines MT-1, MT-2, KH-2 and MT-2 stimulated by phorbol 12-myristate 13-acetate (PMA) were used as target cells in immunofluorescence microscopy (IF) examination with positive rates as 0.20% (2/965), 0.62% (6/965), 0.20% (2/965) and 0.51 (5/965) respectively.	Tetradecanoylphorbol Acetate	106-109	metallothionein 2A	Homo sapiens	54-58
1831130-1	1991	Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens.	Tetradecanoylphorbol Acetate	89-120	interleukin 2	Mus musculus	160-173
1831130-1	1991	Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens.	Tetradecanoylphorbol Acetate	89-120	interleukin 2	Mus musculus	175-178
1831130-1	1991	Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens.	Tetradecanoylphorbol Acetate	89-120	interleukin 4	Mus musculus	211-214
1831130-1	1991	Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens.	Tetradecanoylphorbol Acetate	89-120	interleukin 5	Mus musculus	219-222
1831130-1	1991	Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens.	Tetradecanoylphorbol Acetate	122-125	interleukin 2	Mus musculus	160-173
1831130-1	1991	Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens.	Tetradecanoylphorbol Acetate	122-125	interleukin 2	Mus musculus	175-178
8157661-8	1994	These results indicate that constitutive and PMA-stimulated expression of collagenase is regulated through an IL-1 alpha intermediate.	Tetradecanoylphorbol Acetate	45-48	interleukin-1 alpha	Oryctolagus cuniculus	110-120
1831130-1	1991	Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens.	Tetradecanoylphorbol Acetate	122-125	interleukin 4	Mus musculus	211-214
1831130-1	1991	Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens.	Tetradecanoylphorbol Acetate	122-125	interleukin 5	Mus musculus	219-222
2524528-5	1989	However, CKS-17-BSA inhibited production of IL-2 by murine thymoma cells treated with IL-1 or with 12-O-tetradecanoyl phorbol-13 acetate.	Tetradecanoylphorbol Acetate	99-136	interleukin 2	Mus musculus	44-48
8138592-3	1994	Although TGF-beta alone has no effect on prostaglandin production in Swiss 3T3 cells, we find that TGF-beta augments the ability of tetradecanoyl phorbol acetate (TPA) or serum to stimulate PGE2 production.	Tetradecanoylphorbol Acetate	132-161	transforming growth factor, beta 1	Mus musculus	99-107
2744462-5	1989	Repression is dependent on the glucocorticoid receptor, which binds to the PLF promoter in a region that includes the AP-1 site, and the 31-bp phorbol ester 12-O-tetra decanoylphorbol-13-acetate (TPA)-inducible region is sufficient to mediate glucocorticoid repression.	Tetradecanoylphorbol Acetate	196-199	prolactin family 2, subfamily c, member 2	Mus musculus	75-78
1907374-5	1991	However, the cells retained viability and functional potential because stimulation with phorbol 12-myristate 13-acetate and ionomycin bypassed the block in receptor-mediated signaling and induced IL-2 receptor expression and proliferation of the anergic cells.	Tetradecanoylphorbol Acetate	88-119	interleukin 2	Mus musculus	196-200
8138592-3	1994	Although TGF-beta alone has no effect on prostaglandin production in Swiss 3T3 cells, we find that TGF-beta augments the ability of tetradecanoyl phorbol acetate (TPA) or serum to stimulate PGE2 production.	Tetradecanoylphorbol Acetate	163-166	transforming growth factor, beta 1	Mus musculus	99-107
1771617-2	1991	Differentiation-linked expression of PAI-2 was investigated by adding cell-differentiation promoting agents [such as phorbol myristate acetate (PMA), retinoic acid (RA), dexamethasone (Dex), and recombinant cytokines, including tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), granulocyte-colony stimulating factor (G-CSF), and interleukin-6 (IL-6)] into the culture medium of PL-21 cells.	Tetradecanoylphorbol Acetate	117-142	serpin family B member 2	Homo sapiens	37-42
2470733-4	1989	For each agonist tested (histamine, thrombin, phorbol 12-myristate 13-acetate, and the calcium ionophore A23187) a dose-dependent redistribution of GMP-140 to the endothelial surface was observed which closely paralleled the dose-dependent secretion of vWF into the cell supernatant.	Tetradecanoylphorbol Acetate	46-77	selectin P	Homo sapiens	148-155
8138592-9	1994	TPA-induced accumulation of unspliced TIS10/PGS-2 transcript is augmented by TGF-beta, suggesting that this cytokine exerts its effect on expression of the TIS10/PGS-2 gene by transcriptional regulation.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	38-43
8138592-9	1994	TPA-induced accumulation of unspliced TIS10/PGS-2 transcript is augmented by TGF-beta, suggesting that this cytokine exerts its effect on expression of the TIS10/PGS-2 gene by transcriptional regulation.	Tetradecanoylphorbol Acetate	0-3	decorin	Mus musculus	44-49
2565932-4	1989	Recombinant interleukin 2 (rIL-2), albeit ineffective by itself, leads to vigorous proliferation of DETC when used with either ConA or PMA + ionomycin + IL-1.	Tetradecanoylphorbol Acetate	135-138	interleukin 2	Mus musculus	12-25
1771617-2	1991	Differentiation-linked expression of PAI-2 was investigated by adding cell-differentiation promoting agents [such as phorbol myristate acetate (PMA), retinoic acid (RA), dexamethasone (Dex), and recombinant cytokines, including tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), granulocyte-colony stimulating factor (G-CSF), and interleukin-6 (IL-6)] into the culture medium of PL-21 cells.	Tetradecanoylphorbol Acetate	144-147	serpin family B member 2	Homo sapiens	37-42
2565932-4	1989	Recombinant interleukin 2 (rIL-2), albeit ineffective by itself, leads to vigorous proliferation of DETC when used with either ConA or PMA + ionomycin + IL-1.	Tetradecanoylphorbol Acetate	135-138	interleukin 2	Rattus norvegicus	27-32
8138592-9	1994	TPA-induced accumulation of unspliced TIS10/PGS-2 transcript is augmented by TGF-beta, suggesting that this cytokine exerts its effect on expression of the TIS10/PGS-2 gene by transcriptional regulation.	Tetradecanoylphorbol Acetate	0-3	transforming growth factor, beta 1	Mus musculus	77-85
1771617-6	1991	PAI activity both in the culture medium and in the cell lysate increased approximately 70-fold after exposure to PMA.	Tetradecanoylphorbol Acetate	113-116	serpin family E member 1	Homo sapiens	0-3
8138592-9	1994	TPA-induced accumulation of unspliced TIS10/PGS-2 transcript is augmented by TGF-beta, suggesting that this cytokine exerts its effect on expression of the TIS10/PGS-2 gene by transcriptional regulation.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	156-161
8138592-9	1994	TPA-induced accumulation of unspliced TIS10/PGS-2 transcript is augmented by TGF-beta, suggesting that this cytokine exerts its effect on expression of the TIS10/PGS-2 gene by transcriptional regulation.	Tetradecanoylphorbol Acetate	0-3	decorin	Mus musculus	162-167
2787474-10	1989	(v) In T cells treated with phytohemagglutinin, tetradecanoylphorbol acetate, and cyclosporin A, the modulation of lck expression was associated primarily with changes in levels of type II transcripts.	Tetradecanoylphorbol Acetate	48-76	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	115-118
1713461-6	1991	S6 kinase activation by 12-O-tetradecanoylphorbol 13 acetate was also strongly impaired by treating cells with BCNU whereas activation by 8-bromo-cyclic AMP was slightly reduced.	Tetradecanoylphorbol Acetate	24-60	ribosomal protein S6 kinase B1	Rattus norvegicus	0-9
8138592-10	1994	TGF-beta also augments TPA-induced prostaglandin production, TIS10/PGS-2 antigen accumulation, and TIS10/PGS-2 message induction in primary cultures of mouse embryo fibroblasts.	Tetradecanoylphorbol Acetate	23-26	transforming growth factor, beta 1	Mus musculus	0-8
2521857-1	1989	We have previously reported that both 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) can stimulate the synthesis rate of EGF receptors.	Tetradecanoylphorbol Acetate	38-74	epidermal growth factor	Homo sapiens	151-154
8183247-5	1994	Expression in several cell lines in culture reveals that rapid TRH-R desensitization by TRH and phorbol 12-myristate 13-acetate is cell type specific.	Tetradecanoylphorbol Acetate	96-127	thyrotropin releasing hormone	Homo sapiens	63-66
2521857-1	1989	We have previously reported that both 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) can stimulate the synthesis rate of EGF receptors.	Tetradecanoylphorbol Acetate	76-79	epidermal growth factor	Homo sapiens	151-154
2521857-2	1989	We now show that the MDA468 breast cancer cells express the mRNA for the EGF-like molecule, transforming growth factor-alpha (TGF-alpha), and demonstrate that TPA or EGF cause an accumulation of both EGF receptor and TGF-alpha mRNA.	Tetradecanoylphorbol Acetate	159-162	epidermal growth factor	Homo sapiens	73-76
2521857-3	1989	The levels of EGF receptor mRNA paralleled our earlier protein data, with peak accumulations of 2-3-fold with 10(-9) M EGF and 3-5-fold with 100 ng/ml TPA seen between 6 and 8 h. A 7-fold accumulation of TGF-alpha mRNA was seen following 4 h of treatment with TPA, and a 2-fold accumulation was seen after 8 h with EGF.	Tetradecanoylphorbol Acetate	151-154	epidermal growth factor	Homo sapiens	14-17
2521857-3	1989	The levels of EGF receptor mRNA paralleled our earlier protein data, with peak accumulations of 2-3-fold with 10(-9) M EGF and 3-5-fold with 100 ng/ml TPA seen between 6 and 8 h. A 7-fold accumulation of TGF-alpha mRNA was seen following 4 h of treatment with TPA, and a 2-fold accumulation was seen after 8 h with EGF.	Tetradecanoylphorbol Acetate	260-263	epidermal growth factor	Homo sapiens	14-17
1903411-3	1991	In the present report we have studied various agents that, like TPA, act as partial or complete mitogens for G0 PBL and have determined their effect on phosphorylation of prosolin and on DNA synthesis in rapidly proliferating (IL-2-dependent) human PBL.	Tetradecanoylphorbol Acetate	64-67	stathmin 1	Homo sapiens	171-179
1903411-4	1991	Agents that activate the TCR (OKT3 and PHA), as well as agents that by-pass the receptor but activate biochemical pathways associated with TCR activation (TPA and Ca2(+)-ionophore), all produced rapid phosphorylation of prosolin and prompt down-regulation of DNA synthesis.	Tetradecanoylphorbol Acetate	155-158	stathmin 1	Homo sapiens	220-228
7510863-8	1994	TPA cannot induce the progression phenotype in B1/PKC-AZA cells, but it can reversibly induce an increase in the transcriptional rate and steady-state mRNA levels of PKC beta 1 and c-jun and it increases AP-1 DNA-binding.	Tetradecanoylphorbol Acetate	0-3	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	47-57
2067850-2	1991	Depleting cells of protein kinase C (PKC) by prolonged exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA), blocked v-Src-induced TIS10 expression, but had no effect on v-Src-induced Egr-1 gene expression.	Tetradecanoylphorbol Acetate	105-108	Rous sarcoma oncogene	Mus musculus	121-124
2494003-5	1989	The epidermal ODC activity was increased rapidly following a single application of RRME, and the level of its activation was in proportion to the doses used, although the promoting effect of RRME was weaker than that of 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	220-257	ornithine decarboxylase 1	Rattus norvegicus	14-17
8142369-5	1994	The two phases of FSH beta mRNA elevation induced by GnRH could be mimicked by TPA, while the decrease at 6 h was mimicked by ionomycin.	Tetradecanoylphorbol Acetate	79-82	follicle stimulating hormone subunit beta	Rattus norvegicus	18-26
2468505-3	1989	However, after stimulation with phorbol myristate acetate and phytohemagglutinin, M-, G-, GM- and multi-CSF mRNA became detectable in PBMC, resulting in the secretion of the respective proteins.	Tetradecanoylphorbol Acetate	32-57	interleukin 3	Homo sapiens	98-107
2047762-1	1991	The production and mRNA expression of IL-1 alpha and IL-1 beta by human monocytes was examined after two different stimuli, a protein kinase C (PKC) activator phorbol myristate acetate (PMA) and bacterial lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	159-184	interleukin 1 alpha	Homo sapiens	38-48
2047762-1	1991	The production and mRNA expression of IL-1 alpha and IL-1 beta by human monocytes was examined after two different stimuli, a protein kinase C (PKC) activator phorbol myristate acetate (PMA) and bacterial lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	186-189	interleukin 1 alpha	Homo sapiens	38-48
8078506-0	1994	Changes of G1 cyclins, cdk2, and cyclin A during the differentiation of HL60 cells induced by TPA.	Tetradecanoylphorbol Acetate	94-97	cyclin dependent kinase 2	Homo sapiens	23-27
2785919-5	1989	Furthermore, in normal human peripheral blood mononuclear cells, the expression of ADF mRNA was enhanced by mitogens or phorbol myristate acetate, suggesting a possible involvement of ADF in the lymphocyte activation.	Tetradecanoylphorbol Acetate	120-145	thioredoxin	Homo sapiens	83-86
2785919-5	1989	Furthermore, in normal human peripheral blood mononuclear cells, the expression of ADF mRNA was enhanced by mitogens or phorbol myristate acetate, suggesting a possible involvement of ADF in the lymphocyte activation.	Tetradecanoylphorbol Acetate	120-145	thioredoxin	Homo sapiens	184-187
8078506-5	1994	TPA-treated cells accumulated in G1 phase within 24 h and most of the cells were arrested in this phase at 36 h. The expression of cyclins and cdk2 was studied by Northern blot hybridization of the reverse-transcription polymerase chain reaction (RT-PCR).	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase 2	Homo sapiens	143-147
8078506-9	1994	In contrast, the expression of cyclin D1 mRNA was induced by TPA, while its expression in control cells was undetectable by Northern blot hybridization throughout the cell cycle.	Tetradecanoylphorbol Acetate	61-64	cyclin D1	Homo sapiens	31-40
1903479-4	1991	In human lung fibroblasts and in human umbilical vein endothelial cells, LIF was constitutively expressed and its accumulation was increased in a time-dependent manner following treatment with the phorbol ester TPA and in the presence of the two immediate response cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1-beta.	Tetradecanoylphorbol Acetate	211-214	LIF interleukin 6 family cytokine	Homo sapiens	73-76
8141770-3	1994	Activation of superoxide production by phorbol 12-myristate 13-acetate or formylmethionyl-leucyl-phenylalanine in whole cells, and by SDS in the cell-free assay, led to the dissociation of some of the p21rac2 from rhoGDI and its movement to the plasma membrane together with p47phox and p67phox.	Tetradecanoylphorbol Acetate	39-70	neutrophil cytosolic factor 2	Homo sapiens	287-294
2922288-3	1989	A series of Bal 31 deletions of the human vimentin promoter are used to show that a sequence residing at -700 is responsible for the serum, and also TPA inducibility of this gene.	Tetradecanoylphorbol Acetate	149-152	vimentin	Homo sapiens	42-50
2922288-6	1989	Further deletions and the use of synthetic oligonucleotides demonstrate that a 24-mer containing two AP-1/jun binding sites confer both serum and TPA inducibility upon the human vimentin gene.	Tetradecanoylphorbol Acetate	146-149	vimentin	Homo sapiens	178-186
1870266-2	1991	PAI activity both in the culture medium and in the cell lysate increased approximately 70-fold after exposure to PMA.	Tetradecanoylphorbol Acetate	113-116	serpin family E member 1	Homo sapiens	0-3
8123649-2	1994	At 1 mumol/L, Lp(a) inhibited constitutive TPA secretion by 50% and phorbol myristate acetate- and histamine-enhanced TPA secretion by 40%.	Tetradecanoylphorbol Acetate	68-93	lipoprotein(a)	Homo sapiens	14-19
1850360-8	1991	The pattern of IL2-induced phosphorylation was different from that found following addition of phorbol 12-myristate 13-acetate (PMA) to the cells.	Tetradecanoylphorbol Acetate	128-131	interleukin 2	Mus musculus	15-18
2492204-4	1989	In parallel with these results both TPA and 12(S)-HETE [but not 12(R)-HETE] enhance tumor cell adhesion to endothelial cells, subendothelial matrix and fibronectin, but not to type IV collagen.	Tetradecanoylphorbol Acetate	36-39	fibronectin 1	Mus musculus	152-163
2492204-7	1989	In contrast, a lipoxygenase product of linoleic acid, 13(S)-hydroxyoctadecadienoic acid, inhibited TPA and 12(S)-HETE-enhanced tumor cell adhesion to endothelial cells, subendothelial matrix, and fibronectin.	Tetradecanoylphorbol Acetate	99-102	fibronectin 1	Mus musculus	196-207
8106362-10	1994	In addition to the distinct effects of 1,25-(OH)2-D3 and TPA on PKC isozyme patterns, 1,25-(OH)2-D3 up-regulates both the vitamin D receptor and calbindin D-28K, whereas TPA down-regulates the expression of both proteins.	Tetradecanoylphorbol Acetate	170-173	vitamin D receptor	Bos taurus	122-140
2643439-6	1989	Exposure of human umbilical vein endothelial cells to bradykinin, thrombin or interleukin-1 resulted in negligible release of either hexosaminidase or lactate dehydrogenase (LDH), in contrast to phorbol myristate acetate, which caused a parallel, dose-dependent release of both enzymes.	Tetradecanoylphorbol Acetate	195-220	interleukin 1 alpha	Homo sapiens	78-91
1707036-4	1991	Addition of fetuin or epidermal growth factor (EGF) to incubates with serum-deprived cells increased the ability of TPA to affect growth, but addition of platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-beta) or retinoic acid (RA) was without effect.	Tetradecanoylphorbol Acetate	116-119	epidermal growth factor	Homo sapiens	22-45
1707036-4	1991	Addition of fetuin or epidermal growth factor (EGF) to incubates with serum-deprived cells increased the ability of TPA to affect growth, but addition of platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-beta) or retinoic acid (RA) was without effect.	Tetradecanoylphorbol Acetate	116-119	epidermal growth factor	Homo sapiens	47-50
7905497-7	1994	In response to primary stimulation with PMA and ionomycin, cells primed with IL-4 + IL-2 produce IL-4, IL-5, and IL-10 and the same levels of IL-2 and IFN-gamma as IL-4-primed cells.	Tetradecanoylphorbol Acetate	40-43	interleukin 5	Homo sapiens	103-107
2011401-3	1991	In unstimulated proliferating JURKAT cells, high levels of C-MYC, N-RAS, and BCL2 mRNAs were found that diminished rapidly following TPA-induced cessation of growth.	Tetradecanoylphorbol Acetate	133-136	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	59-64
2467815-3	1989	IL 4 inhibits both the spontaneous and the phorbol myristate acetate (PMA)-induced hyperexpression of CD5 on tonsil B cells.	Tetradecanoylphorbol Acetate	43-68	CD5 molecule	Homo sapiens	102-105
2467815-3	1989	IL 4 inhibits both the spontaneous and the phorbol myristate acetate (PMA)-induced hyperexpression of CD5 on tonsil B cells.	Tetradecanoylphorbol Acetate	70-73	CD5 molecule	Homo sapiens	102-105
2011401-4	1991	In contrast, accumulation of mRNAs for the C-FOS, C-JUN, and EGR-1 genes increased markedly in TPA-treated cells and preceded the induction of IL2R-alpha mRNA.	Tetradecanoylphorbol Acetate	95-98	early growth response 1	Homo sapiens	61-66
2467815-4	1989	In contrast, IL 4 only suppresses the PMA-induced hyperexpression of CD5 on B-CLL, whereas the spontaneous CD5 expression is essentially unaffected.	Tetradecanoylphorbol Acetate	38-41	CD5 molecule	Homo sapiens	69-72
8142009-4	1994	In nuclear protein extracts of 308, AP-1 sequence-specific binding to an oligonucleotide containing a single high-affinity AP-1 binding site was induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate, as determined by gel shift analysis.	Tetradecanoylphorbol Acetate	175-211	jun proto-oncogene	Mus musculus	36-40
2011401-8	1991	Thus, although C-MYC and BCL2 proto-oncogene expression correlated with proliferation in TPA-treated JURKAT cells, continuous over-expression of even the combination of these oncogenes was insufficient for abrogating the effects of TPA in these leukemic T cells.	Tetradecanoylphorbol Acetate	89-92	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	15-20
8142009-4	1994	In nuclear protein extracts of 308, AP-1 sequence-specific binding to an oligonucleotide containing a single high-affinity AP-1 binding site was induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate, as determined by gel shift analysis.	Tetradecanoylphorbol Acetate	175-211	jun proto-oncogene	Mus musculus	123-127
1705899-3	1991	This inhibitor selectively blocks the mRNA expression of the proto-oncogene c-myc in response to the phorbol ester, PMA.	Tetradecanoylphorbol Acetate	116-119	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	61-81
1708123-2	1991	JunB expression is modulated by a wide variety of extracellular stimuli, such as serum, growth factors, phorbol esters (TPA) and activators of protein kinase A (PKA).	Tetradecanoylphorbol Acetate	120-123	jun B proto-oncogene	Mus musculus	0-4
2462935-4	1989	Only 12-O-tetradecanoylphorbol-13-acetate (TPA) induced CD5 expression on highly purified splenic B cells, whereas anti-immunoglobulin (anti-Ig), Epstein-Barr virus, anti-CD20, recombinant interleukin-1 (rIL-1), rIL-2, rIL-4, recombinant interferon-gamma (rINF-gamma), and B-cell growth factor all failed to induce CD5 expression.	Tetradecanoylphorbol Acetate	5-41	CD5 molecule	Homo sapiens	56-59
2462935-4	1989	Only 12-O-tetradecanoylphorbol-13-acetate (TPA) induced CD5 expression on highly purified splenic B cells, whereas anti-immunoglobulin (anti-Ig), Epstein-Barr virus, anti-CD20, recombinant interleukin-1 (rIL-1), rIL-2, rIL-4, recombinant interferon-gamma (rINF-gamma), and B-cell growth factor all failed to induce CD5 expression.	Tetradecanoylphorbol Acetate	43-46	CD5 molecule	Homo sapiens	56-59
8290598-5	1994	The block to surface immunoglobulin crosslinking-induced permissivity in cells expressing wild-type LMP2 could be bypassed by raising intracellular free calcium levels with an ionophore and by activating protein kinase C with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	226-257	proteasome 20S subunit beta 9	Homo sapiens	100-104
2576219-5	1989	Stimulation of lymphokine synthesis by phorbol myristate acetate (PMA) and the Ca2+ ionophore ionomycin, or by ionomycin alone, mimicked the TCR-dependent response.	Tetradecanoylphorbol Acetate	39-64	T cell receptor alpha variable 6-3	Mus musculus	141-144
7514078-5	1994	Stimulation with phorbol 12-myristate 13-acetate (PMA), however, gave rise to large, plastic adherent cells which also showed strong homotypic adhesion, expressed CD62L at minimal levels and CD11c at comparably highest levels and altogether mimicked the large cell variant of EF B cells.	Tetradecanoylphorbol Acetate	17-48	integrin subunit alpha X	Homo sapiens	191-196
2576219-5	1989	Stimulation of lymphokine synthesis by phorbol myristate acetate (PMA) and the Ca2+ ionophore ionomycin, or by ionomycin alone, mimicked the TCR-dependent response.	Tetradecanoylphorbol Acetate	66-69	T cell receptor alpha variable 6-3	Mus musculus	141-144
1708123-4	1991	Here we show that the junB promoter is activated by serum, TPA, and activated PKA.	Tetradecanoylphorbol Acetate	59-62	jun B proto-oncogene	Mus musculus	22-26
1900439-4	1991	Addition of TPA or DiC8 immediately after glycerol shock resulted in a 5-7-fold increase in the number of cells expressing beta-galactosidase as well as a concomitant increase in the total amount of beta-galactosidase activity in the population during periods of transient and stable expression.	Tetradecanoylphorbol Acetate	12-15	galactosidase, beta 1	Mus musculus	123-141
1900439-4	1991	Addition of TPA or DiC8 immediately after glycerol shock resulted in a 5-7-fold increase in the number of cells expressing beta-galactosidase as well as a concomitant increase in the total amount of beta-galactosidase activity in the population during periods of transient and stable expression.	Tetradecanoylphorbol Acetate	12-15	galactosidase, beta 1	Mus musculus	199-217
2613862-4	1989	EGF also stimulated phosphorylation of an Mr 80,000 protein whose pI, phosphopeptide map, and phosphoamino acid pattern were identical to those of an Mr 80,000 protein phosphorylated in response to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	198-229	epidermal growth factor	Mus musculus	0-3
7514078-5	1994	Stimulation with phorbol 12-myristate 13-acetate (PMA), however, gave rise to large, plastic adherent cells which also showed strong homotypic adhesion, expressed CD62L at minimal levels and CD11c at comparably highest levels and altogether mimicked the large cell variant of EF B cells.	Tetradecanoylphorbol Acetate	50-53	integrin subunit alpha X	Homo sapiens	191-196
8257426-2	1993	Evidence has been accumulated that in phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, the translocation to the plasma membrane of the cytosolic components p47phox and p67phox and the phosphorylation of p47phox are essential steps in activation of NADPH oxidase.	Tetradecanoylphorbol Acetate	71-74	neutrophil cytosolic factor 2	Homo sapiens	181-188
8257426-8	1993	That the phosphorylated p67 protein we identified in immunoprecipitation experiments was p67phox was confirmed by the observation that no phosphorylated band of 67 kDa was immunoprecipitated from the cytosol and membranes of PMA-stimulated neutrophils from a p67phox-deficient chronic granulomatous disease patient.	Tetradecanoylphorbol Acetate	225-228	neutrophil cytosolic factor 2	Homo sapiens	89-96
2615469-3	1989	In TPA-treated cells, the activities of anabolic enzymes, TdR kinase (TK; EC 2.7.1.21) and thymidylate synthase (TS; EC 2.1.1.45), declined to 15% and 18% of those of untreated cells by 96 h. Incorporation of 3H-TdR and 3H-deoxyuridine also decreased in parallel with decline in enzyme activities.	Tetradecanoylphorbol Acetate	3-6	thymidylate synthetase	Homo sapiens	91-111
1703047-3	1991	FK506 partially suppressed IL-1 alpha release, from macrophage-like U937 cells stimulated with phorbol myristate acetate and from human monocytes and alveolar macrophages activated with lipopolysaccharide, in a dose-dependent manner.	Tetradecanoylphorbol Acetate	95-120	interleukin 1 alpha	Homo sapiens	27-37
7907262-3	1993	bFGF reduced neuron damage caused by the PKC-activating phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), glutamate and ischaemia-like culture conditions.	Tetradecanoylphorbol Acetate	108-111	fibroblast growth factor 2	Rattus norvegicus	0-4
7907262-5	1993	Moreover, bFGF prevented the loss of PKC occurring after prolonged exposure to TPA or ischaemia-like conditions.	Tetradecanoylphorbol Acetate	79-82	fibroblast growth factor 2	Rattus norvegicus	10-14
1671835-1	1991	The ability of CD4+ T cells from CBA/Rij mice to produce interleukin (IL) 2 after stimulation with anti-CD3, concanavalin A, or the combination of phorbol 12-myristate 13-acetate and ionomycin declines during aging.	Tetradecanoylphorbol Acetate	147-178	interleukin 2	Mus musculus	57-75
2478147-1	1989	Proto-oncogene c-fos is induced by many types of cellular stimuli, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), serum (fetal bovine), calcium ionophore A23187, and dibutyryl cAMP (But2cAMP).	Tetradecanoylphorbol Acetate	75-111	Fos proto-oncogene, AP-1 transcription factor subunit	Bos taurus	0-20
8255104-11	1993	Cells exposed to phorbol myristate acetate (PMA) had increased expression of CD11a, CD11b, CD18, CD45RO, and HLA-DR, whereas expression of CD15 and CD30 was markedly decreased.	Tetradecanoylphorbol Acetate	17-42	integrin subunit alpha L	Homo sapiens	77-82
2478147-1	1989	Proto-oncogene c-fos is induced by many types of cellular stimuli, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), serum (fetal bovine), calcium ionophore A23187, and dibutyryl cAMP (But2cAMP).	Tetradecanoylphorbol Acetate	113-116	Fos proto-oncogene, AP-1 transcription factor subunit	Bos taurus	0-20
1845931-4	1991	PMA (12-phorbol 13-myristic acid) also induced Raf-1 phosphorylation in MO7 cells, but the resulting alteration in electrophoretic mobility was different than that observed after GM-CSF or IL-3.	Tetradecanoylphorbol Acetate	0-3	interleukin 3	Homo sapiens	189-193
8218368-4	1993	The PMA-induced decrease in the O2.- production may be related to the inactivation of NADPH-producing enzymes such as glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase that we have found with age.	Tetradecanoylphorbol Acetate	4-7	glucose-6-phosphate dehydrogenase	Rattus norvegicus	118-151
1985780-6	1991	Upon 12-O-tetradecanoylphorbol-13-acetate treatment, a protracted down-regulation of the immunodetectable alpha-PKC as well as constitutively high levels of c-fos mRNA were observed when oncogenic Ha-ras was expressed.	Tetradecanoylphorbol Acetate	5-41	FBJ osteosarcoma oncogene	Mus musculus	157-162
1985944-4	1991	However, using a peptide substrate corresponding to residues 720-737 of protein kinase C-epsilon, Ca2(+)-, phospholipid-, and diacylglycerol-dependent kinase activity was reduced only modestly after exposure to TPA.	Tetradecanoylphorbol Acetate	211-214	protein kinase C epsilon	Homo sapiens	72-96
2473448-6	1989	Depolarization-induced LH-RH release also did not occur in the presence of 10(-4) or 10(-6) M norepinephrine, 10(-7) M 12-O-tetradecanoylphorbol-13-acetate (TPA, PMA), 10(-5) M forskolin or in female rats.	Tetradecanoylphorbol Acetate	157-160	gonadotropin releasing hormone 1	Rattus norvegicus	23-28
2473448-6	1989	Depolarization-induced LH-RH release also did not occur in the presence of 10(-4) or 10(-6) M norepinephrine, 10(-7) M 12-O-tetradecanoylphorbol-13-acetate (TPA, PMA), 10(-5) M forskolin or in female rats.	Tetradecanoylphorbol Acetate	162-165	gonadotropin releasing hormone 1	Rattus norvegicus	23-28
2629775-2	1989	The phorbol ester (TPA) also triggered a rapid increase in S6 kinase activity.	Tetradecanoylphorbol Acetate	19-22	ribosomal protein S6 kinase B1	Rattus norvegicus	59-68
7693343-0	1993	Transforming growth factor beta 1 induction is associated with transforming growth factors beta 2 and beta 3 down-modulation in 12-O-tetradecanoylphorbol-13-acetate-induced skin hyperplasia.	Tetradecanoylphorbol Acetate	128-164	transforming growth factor, beta 1	Mus musculus	0-33
2973375-7	1988	The simultaneous addition of 3-ABA (10(-4) mol/l) not only fully checked the mitogenic effects of TPA, but even suppressed about two-thirds of the TPA-elicited nuclear incorporation of [3H]NAD by the permeabilized hepatocytes, thus showing that a significant curtailment of the TPA-activated ADPRT did occur is association with the abatement of the mitogenic effects of TPA by this inhibitor.	Tetradecanoylphorbol Acetate	147-150	poly (ADP-ribose) polymerase 1	Rattus norvegicus	292-297
2973375-7	1988	The simultaneous addition of 3-ABA (10(-4) mol/l) not only fully checked the mitogenic effects of TPA, but even suppressed about two-thirds of the TPA-elicited nuclear incorporation of [3H]NAD by the permeabilized hepatocytes, thus showing that a significant curtailment of the TPA-activated ADPRT did occur is association with the abatement of the mitogenic effects of TPA by this inhibitor.	Tetradecanoylphorbol Acetate	147-150	poly (ADP-ribose) polymerase 1	Rattus norvegicus	292-297
1985944-7	1991	The immunoreactive 76-kDa protein observed after TPA treatment comigrated on DEAE chromatography with the kinase activity phosphorylating the protein kinase C-epsilon peptide and had an elution profile similar to protein kinase C derived from untreated cells.	Tetradecanoylphorbol Acetate	49-52	protein kinase C epsilon	Homo sapiens	142-166
7693343-1	1993	Acute treatment of mouse skin with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces marked epidermal hyperplasia, which is well evident by 24 h and maximal by 48-72 h. These effects are associated with the early induction of transforming growth factor (TGF) beta 1 expression in the epidermis.	Tetradecanoylphorbol Acetate	54-90	transforming growth factor, beta 1	Mus musculus	246-285
2973375-7	1988	The simultaneous addition of 3-ABA (10(-4) mol/l) not only fully checked the mitogenic effects of TPA, but even suppressed about two-thirds of the TPA-elicited nuclear incorporation of [3H]NAD by the permeabilized hepatocytes, thus showing that a significant curtailment of the TPA-activated ADPRT did occur is association with the abatement of the mitogenic effects of TPA by this inhibitor.	Tetradecanoylphorbol Acetate	147-150	poly (ADP-ribose) polymerase 1	Rattus norvegicus	292-297
1985972-4	1991	The study of EGF binding to only low affinity receptors was performed with cells pretreated with the phorbol ester phorbol 12-myristate 13-acetate, which induces a conversion of high affinity receptors to low affinity receptors.	Tetradecanoylphorbol Acetate	115-146	epidermal growth factor	Homo sapiens	13-16
7693343-1	1993	Acute treatment of mouse skin with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces marked epidermal hyperplasia, which is well evident by 24 h and maximal by 48-72 h. These effects are associated with the early induction of transforming growth factor (TGF) beta 1 expression in the epidermis.	Tetradecanoylphorbol Acetate	92-95	transforming growth factor, beta 1	Mus musculus	246-285
7693343-7	1993	Thus, differential control of the 3 TGF-beta isoforms appears to be a likely determinant of normal skin homeostasis and could be at least partially responsible for TPA-induced skin hyperplasia.	Tetradecanoylphorbol Acetate	164-167	transforming growth factor, beta 1	Mus musculus	36-44
8288312-7	1993	PMA-induced translocation of PKC-beta was difficult to detect by Western blot.	Tetradecanoylphorbol Acetate	0-3	protein kinase C beta	Homo sapiens	29-37
1987282-5	1991	In TPA-induced differentiation of HL-60 cells, both fyn and lyn genes, but not fgr gene, were expressed.	Tetradecanoylphorbol Acetate	3-6	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	52-55
3191568-4	1988	Single or multiple application (2 X/week for 4 weeks) of 1, 2 or 5 nmol of TPA to the skin of CD-1 mice produced a dose-dependent increase in the number of epidermal non-cornified cell layers, epidermal thickness, leukocyte infiltration and intracellular edema.	Tetradecanoylphorbol Acetate	75-78	CD1 antigen complex	Mus musculus	94-98
8402696-5	1993	In contrast, both hL-31 transcripts and protein were detected at 8 h after addition of 17 nM 12-O-tetradecanoylphorbol-13-acetate and reached maximal levels at 24 h. Addition of actinomycin D along with 12-O-tetradecanoylphorbol-13-acetate blocked accumulation of hL-31 mRNA.	Tetradecanoylphorbol Acetate	93-129	galectin 3	Homo sapiens	18-23
3191568-10	1988	CD-1 mice were initiated with 200 nmol 7,12-dimethylbenz[a]anthracene and then treated with 1 nmol TPA or 2.5 mumol sn-1,2-didecanoylglycerol twice a week for 28 weeks.	Tetradecanoylphorbol Acetate	99-102	CD1 antigen complex	Mus musculus	0-4
8402696-5	1993	In contrast, both hL-31 transcripts and protein were detected at 8 h after addition of 17 nM 12-O-tetradecanoylphorbol-13-acetate and reached maximal levels at 24 h. Addition of actinomycin D along with 12-O-tetradecanoylphorbol-13-acetate blocked accumulation of hL-31 mRNA.	Tetradecanoylphorbol Acetate	203-239	galectin 3	Homo sapiens	18-23
3192624-1	1988	We have shown that platelet-activating factor (PAF), a weak primary stimulus for neutrophil superoxide generation, synergistically enhances neutrophil oxidative responses to the tumor promoter phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	193-218	PCNA clamp associated factor	Homo sapiens	19-45
1877391-5	1991	In addition to the clear difference between cPKC and nPKC, functional diversity among conventional PKCs has also been demonstrated; PKC gamma differs in its competence to mediate the signal toward transcriptional activation through TPA-responsive cis-acting elements from cPKC alpha and nPKC epsilon.	Tetradecanoylphorbol Acetate	232-235	protein kinase C gamma	Homo sapiens	132-141
8402696-6	1993	In contrast, addition of actinomycin D to 12-O-tetradecanoylphorbol-13-acetate-treated HL-60 cells that had already accumulated high levels of hL-31 mRNA did not cause significant reduction in RNA levels until 6-8 h had elapsed.	Tetradecanoylphorbol Acetate	42-78	galectin 3	Homo sapiens	143-148
3192624-1	1988	We have shown that platelet-activating factor (PAF), a weak primary stimulus for neutrophil superoxide generation, synergistically enhances neutrophil oxidative responses to the tumor promoter phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	193-218	PCNA clamp associated factor	Homo sapiens	47-50
3192624-1	1988	We have shown that platelet-activating factor (PAF), a weak primary stimulus for neutrophil superoxide generation, synergistically enhances neutrophil oxidative responses to the tumor promoter phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	220-223	PCNA clamp associated factor	Homo sapiens	19-45
7691832-8	1993	TPA-induced mac-NOS and TIS10/PGS-2 mRNA accumulation patterns are similar.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	24-29
3192624-1	1988	We have shown that platelet-activating factor (PAF), a weak primary stimulus for neutrophil superoxide generation, synergistically enhances neutrophil oxidative responses to the tumor promoter phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	220-223	PCNA clamp associated factor	Homo sapiens	47-50
3192624-2	1988	Since PMA is known to cause cytosol-to-membrane shift of calcium-activated, phospholipid-dependent protein kinase (protein kinase c, PKC) in human neutrophils, we investigated the role of PAF in modifying PMA-induced PKC activation/translocation.	Tetradecanoylphorbol Acetate	6-9	PCNA clamp associated factor	Homo sapiens	188-191
3192624-5	1988	However, in the presence of PAF and PMA, total particulate protein kinase activity increased markedly over that detected in the presence of PMA alone (144 +/- 9 pmoles 32P/10(7)PMN/minute in cells treated with 20 ng/ml PMA compared to 267 +/- 24 pmoles 32P in cells exposed to PMA and 10(-6)M PAF).	Tetradecanoylphorbol Acetate	36-39	PCNA clamp associated factor	Homo sapiens	293-296
3192624-5	1988	However, in the presence of PAF and PMA, total particulate protein kinase activity increased markedly over that detected in the presence of PMA alone (144 +/- 9 pmoles 32P/10(7)PMN/minute in cells treated with 20 ng/ml PMA compared to 267 +/- 24 pmoles 32P in cells exposed to PMA and 10(-6)M PAF).	Tetradecanoylphorbol Acetate	140-143	PCNA clamp associated factor	Homo sapiens	28-31
3192624-5	1988	However, in the presence of PAF and PMA, total particulate protein kinase activity increased markedly over that detected in the presence of PMA alone (144 +/- 9 pmoles 32P/10(7)PMN/minute in cells treated with 20 ng/ml PMA compared to 267 +/- 24 pmoles 32P in cells exposed to PMA and 10(-6)M PAF).	Tetradecanoylphorbol Acetate	140-143	PCNA clamp associated factor	Homo sapiens	28-31
1772973-2	1991	The lines used were: IM-9, a human lymphoblastoid B-cell line that spontaneously produces IgG; EL-4, a murine T-cell line that produces interleukin-2 (IL-2) on stimulation with phorbol myristate acetate; and CTLL-2, an IL-2-dependent murine T-cell line.	Tetradecanoylphorbol Acetate	177-202	interleukin 2	Mus musculus	151-155
7691832-8	1993	TPA-induced mac-NOS and TIS10/PGS-2 mRNA accumulation patterns are similar.	Tetradecanoylphorbol Acetate	0-3	decorin	Mus musculus	30-35
8359233-3	1993	The present studies demonstrate that dexamethasone (dex) and cyclosporin A (CsA) resulted in inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced monocytic differentiation of HL60 cells, as well as TPA induction of c-fms and CSF-1 transcripts.	Tetradecanoylphorbol Acetate	145-148	colony stimulating factor 1 receptor	Homo sapiens	227-232
3141409-2	1988	Arginine vasopressin (AVP) and phorbol myristate acetate (PMA) both stimulated PLA2 activity as assayed by the release of free arachidonic acid from exogenously added [14C]arachidonyl-phosphatidylcholine.	Tetradecanoylphorbol Acetate	31-56	phospholipase A2 group IB	Rattus norvegicus	79-83
3141409-2	1988	Arginine vasopressin (AVP) and phorbol myristate acetate (PMA) both stimulated PLA2 activity as assayed by the release of free arachidonic acid from exogenously added [14C]arachidonyl-phosphatidylcholine.	Tetradecanoylphorbol Acetate	58-61	phospholipase A2 group IB	Rattus norvegicus	79-83
8359233-6	1993	Measurements of c-fms transcript half-life confirmed post-transcriptional regulation of c-fms transcript levels after the addition of dex or CsA to TPA, both of which resulted in a decrease in c-fms mRNA half-life.	Tetradecanoylphorbol Acetate	148-151	colony stimulating factor 1 receptor	Homo sapiens	16-21
8359233-6	1993	Measurements of c-fms transcript half-life confirmed post-transcriptional regulation of c-fms transcript levels after the addition of dex or CsA to TPA, both of which resulted in a decrease in c-fms mRNA half-life.	Tetradecanoylphorbol Acetate	148-151	colony stimulating factor 1 receptor	Homo sapiens	88-93
1652433-12	1991	While the mechanism of TGF beta action is not clear, A-II probably is acting through protein kinase C. Indeed the protein kinase C activating phorbol ester, TPA, mimicked the inhibitory effects of A-II on 3 beta HSD and P450(17 alpha).	Tetradecanoylphorbol Acetate	157-160	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	Bos taurus	205-215
8359233-6	1993	Measurements of c-fms transcript half-life confirmed post-transcriptional regulation of c-fms transcript levels after the addition of dex or CsA to TPA, both of which resulted in a decrease in c-fms mRNA half-life.	Tetradecanoylphorbol Acetate	148-151	colony stimulating factor 1 receptor	Homo sapiens	88-93
8359233-7	1993	Others have suggested that TPA results in the stabilization of c-fms mRNA in HL60 cells through induction of a labile mRNA stabilizing protein.	Tetradecanoylphorbol Acetate	27-30	colony stimulating factor 1 receptor	Homo sapiens	63-68
8357831-5	1993	While the previously reported mechanisms about the regulation of CSF-1 expression in TPA-treated-monocytes (Horiguchi, J., Sariban, E. and Kufe, D. (1988) Mol.	Tetradecanoylphorbol Acetate	85-88	colony stimulating factor 1	Rattus norvegicus	65-70
1706346-6	1991	Prolonged pretreatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) also prevented the induction of immediate early growth factor-regulated genes in response to neu activation.	Tetradecanoylphorbol Acetate	28-65	erb-b2 receptor tyrosine kinase 2	Mus musculus	165-168
1706346-6	1991	Prolonged pretreatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) also prevented the induction of immediate early growth factor-regulated genes in response to neu activation.	Tetradecanoylphorbol Acetate	67-70	erb-b2 receptor tyrosine kinase 2	Mus musculus	165-168
1985107-2	1991	Two of the cytosolic NADPH oxidase components, p47-phox and p67-phox, translocate to the plasma membrane in normal neutrophils stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	143-168	pleckstrin	Homo sapiens	47-50
1985107-2	1991	Two of the cytosolic NADPH oxidase components, p47-phox and p67-phox, translocate to the plasma membrane in normal neutrophils stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	170-173	pleckstrin	Homo sapiens	47-50
1713637-6	1991	In contrast, IL-1 beta, TNF, and TPA equally stimulated increased levels of M-CSF, GM-CSF, IL-1 beta and IL-6 RNAs.	Tetradecanoylphorbol Acetate	33-36	colony stimulating factor 1	Homo sapiens	76-81
2847543-8	1988	Furthermore the phorbol ester derivative, 12-O-tetradecanoyl phorbol-13-acetate, dramatically stimulated gastrin release (10 times the basal value).	Tetradecanoylphorbol Acetate	42-79	gastrin	Homo sapiens	105-112
3169138-1	1988	The induction of differentiation in SH-SY5Y human neuroblastoma cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is accompanied by a rapid and a transient expression of c-fos mRNA and a down-regulation of c-myc mRNA.	Tetradecanoylphorbol Acetate	75-111	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	210-215
3169138-1	1988	The induction of differentiation in SH-SY5Y human neuroblastoma cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is accompanied by a rapid and a transient expression of c-fos mRNA and a down-regulation of c-myc mRNA.	Tetradecanoylphorbol Acetate	113-116	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	210-215
1713637-6	1991	In contrast, IL-1 beta, TNF, and TPA equally stimulated increased levels of M-CSF, GM-CSF, IL-1 beta and IL-6 RNAs.	Tetradecanoylphorbol Acetate	33-36	colony stimulating factor 2	Homo sapiens	83-89
8102559-15	1993	TPA-activated B-CLL cells showed a 1.2- to 13-fold increased expression of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), lymphocyte function-associated antigen (LFA)-1, and LFA-3, whereas expression of HLA class II molecules increased up to 5 times.	Tetradecanoylphorbol Acetate	0-3	integrin subunit alpha L	Homo sapiens	142-188
1656316-2	1991	Acute treatment (30 min) with forskolin (10(-5) M) or phorbol 12 myristate 13 acetate (10(-7) M) resulted, respectively, in a two- and seven-fold increase in methionine-enkephalin secretion.	Tetradecanoylphorbol Acetate	54-85	proenkephalin	Rattus norvegicus	169-179
3171588-0	1988	Properties of the 12-O-tetradecanoylphorbol-13-acetate-stimulated S6 kinase from rat astroglial cells.	Tetradecanoylphorbol Acetate	18-54	ribosomal protein S6 kinase B1	Rattus norvegicus	66-75
3171588-1	1988	The S6 kinase activity of astroglial cells in primary culture stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) has been studied.	Tetradecanoylphorbol Acetate	76-112	ribosomal protein S6 kinase B1	Rattus norvegicus	4-13
3171588-1	1988	The S6 kinase activity of astroglial cells in primary culture stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) has been studied.	Tetradecanoylphorbol Acetate	114-117	ribosomal protein S6 kinase B1	Rattus norvegicus	4-13
3171588-10	1988	The TPA-stimulated S6 kinase resembles the insulin-, fibroblast growth factor- and cyclic AMP-stimulated enzymes, suggesting that several pathways might activate the same entity.	Tetradecanoylphorbol Acetate	4-7	ribosomal protein S6 kinase B1	Rattus norvegicus	19-28
1656316-3	1991	Chronic treatment with forskolin or phorbol 12 myristate 13 acetate (24 h) induced a 100% increase in methionine-enkephalin content (forskolin) and on the other hand a 50% decrease in methionine-enkephalin (phorbol 12 myristate 13 acetate).	Tetradecanoylphorbol Acetate	36-67	proenkephalin	Rattus norvegicus	113-123
1656316-3	1991	Chronic treatment with forskolin or phorbol 12 myristate 13 acetate (24 h) induced a 100% increase in methionine-enkephalin content (forskolin) and on the other hand a 50% decrease in methionine-enkephalin (phorbol 12 myristate 13 acetate).	Tetradecanoylphorbol Acetate	36-67	proenkephalin	Rattus norvegicus	195-205
8102559-15	1993	TPA-activated B-CLL cells showed a 1.2- to 13-fold increased expression of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), lymphocyte function-associated antigen (LFA)-1, and LFA-3, whereas expression of HLA class II molecules increased up to 5 times.	Tetradecanoylphorbol Acetate	0-3	CD58 molecule	Homo sapiens	194-199
8394339-3	1993	A construct containing -118/-101 base pairs of CYP11A sequence retains the same degree of stimulation by forskolin and inhibition by co-treatment with phorbol 12-myristate 13-acetate as larger constructs.	Tetradecanoylphorbol Acetate	151-182	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	47-53
1656316-6	1991	However, after stimulation with phorbol 12 myristate 13 acetate, the more potent methionine-enkephalin secretagogue, increased peptide synthesis is not sufficient to replenish methionine-enkephalin intracellular stores.	Tetradecanoylphorbol Acetate	32-63	proenkephalin	Rattus norvegicus	92-102
1844247-9	1991	Prolonged treatment of R6 cells with TPA caused total loss of cPKC alpha, nPKC delta and nPKC zeta but only a 60% reduction in nPKC epsilon.	Tetradecanoylphorbol Acetate	37-40	protein kinase C epsilon	Homo sapiens	127-139
3062367-2	1988	When human lymphocytic CEM cells were treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), the level of the ets-2 protein was quickly elevated 5- to 20-fold.	Tetradecanoylphorbol Acetate	70-106	ETS proto-oncogene 2, transcription factor	Homo sapiens	131-136
3062367-2	1988	When human lymphocytic CEM cells were treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), the level of the ets-2 protein was quickly elevated 5- to 20-fold.	Tetradecanoylphorbol Acetate	108-111	ETS proto-oncogene 2, transcription factor	Homo sapiens	131-136
3062367-4	1988	The increase in the ets-2 protein was due to stabilization of the protein, because the protein had a half-life of more than 2 h in the presence of TPA and the ets-2 mRNA level did not increase significantly upon TPA treatment.	Tetradecanoylphorbol Acetate	147-150	ETS proto-oncogene 2, transcription factor	Homo sapiens	20-25
3062367-4	1988	The increase in the ets-2 protein was due to stabilization of the protein, because the protein had a half-life of more than 2 h in the presence of TPA and the ets-2 mRNA level did not increase significantly upon TPA treatment.	Tetradecanoylphorbol Acetate	212-215	ETS proto-oncogene 2, transcription factor	Homo sapiens	20-25
8345183-13	1993	In constrast, both splenic T cells and unseparated lymph node cells showed enhanced binding to merosin after PMA stimulation.	Tetradecanoylphorbol Acetate	109-112	laminin, alpha 2	Mus musculus	95-102
3062367-5	1988	The protein synthesis inhibitor cycloheximide enhanced the effect of TPA on the ets-2 protein and could itself slow turnover of the protein.	Tetradecanoylphorbol Acetate	69-72	ETS proto-oncogene 2, transcription factor	Homo sapiens	80-85
3265112-1	1988	We have performed a comparative study of the regulation by glucocorticoids and phorbol 12-myristate 13-acetate (PMA) of the production of type 1 plasminogen activator inhibitor (PAI-1) by 12 human cell lines.	Tetradecanoylphorbol Acetate	79-110	serpin family E member 1	Homo sapiens	178-183
2124239-3	1990	To examine the role of protein kinase C (PKC) in IL-1-mediated PGE2 production, we treated cells with PMA, which stimulated PGE2 production suggesting a positive role for PKC activation in the regulation of PGE2 synthesis.	Tetradecanoylphorbol Acetate	102-105	interleukin 1 alpha	Homo sapiens	49-53
8394087-3	1993	Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8.	Tetradecanoylphorbol Acetate	21-52	integrin subunit alpha L	Homo sapiens	152-157
3265112-1	1988	We have performed a comparative study of the regulation by glucocorticoids and phorbol 12-myristate 13-acetate (PMA) of the production of type 1 plasminogen activator inhibitor (PAI-1) by 12 human cell lines.	Tetradecanoylphorbol Acetate	112-115	serpin family E member 1	Homo sapiens	178-183
3265112-7	1988	In addition, PMA-induced differentiation of the monocyte cell line U937 and the promyelocytic cell line HL-60 into macrophage-like cells was found to be correlated with an up to 100-fold increase in PAI-1 accumulation.	Tetradecanoylphorbol Acetate	13-16	serpin family E member 1	Homo sapiens	199-204
8398907-4	1993	The finding that these cells also fail to exhibit adherence or induction of the tumor necrosis factor and c-fms genes further supports their resistance to TPA-induced differentiation.	Tetradecanoylphorbol Acetate	155-158	colony stimulating factor 1 receptor	Homo sapiens	106-111
2133249-5	1990	tPA/PAI-1 complex levels were lower than tPA levels, suggesting the presence of other inhibitors.	Tetradecanoylphorbol Acetate	0-3	serpin family E member 1	Homo sapiens	4-9
8324215-9	1993	Complete release of platelet clusterin occurred at optimal doses of A23187, phorbol myristate acetate (PMA), and thrombin.	Tetradecanoylphorbol Acetate	76-101	clusterin	Homo sapiens	29-38
1701347-6	1990	Analysis at the mRNA level revealed that both N-myc and HLA class I RNA steady-state levels could be modulated by several substances, including recombinant gamma-interferon, phorbol myristate acetate, dibutyryl cyclic AMP, and epithelial growth factor and were not necessarily linked.	Tetradecanoylphorbol Acetate	174-199	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	46-51
2851595-6	1988	Potentiation of the action of EGF by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA), indicates that activation of protein kinase C and an influx of Ca2+ share a common mechanism for initiating DNA synthesis.	Tetradecanoylphorbol Acetate	56-93	epidermal growth factor	Homo sapiens	30-33
2851595-6	1988	Potentiation of the action of EGF by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA), indicates that activation of protein kinase C and an influx of Ca2+ share a common mechanism for initiating DNA synthesis.	Tetradecanoylphorbol Acetate	95-98	epidermal growth factor	Homo sapiens	30-33
8324215-9	1993	Complete release of platelet clusterin occurred at optimal doses of A23187, phorbol myristate acetate (PMA), and thrombin.	Tetradecanoylphorbol Acetate	103-106	clusterin	Homo sapiens	29-38
8391878-0	1993	Regulation of release of hepatocyte growth factor from human promyelocytic leukemia cells, HL-60, by 1,25-dihydroxyvitamin D3, 12-O-tetradecanoylphorbol 13-acetate, and dibutyryl cyclic adenosine monophosphate.	Tetradecanoylphorbol Acetate	127-163	hepatocyte growth factor	Homo sapiens	25-49
3139757-3	1988	Elevated H2O2 release in response to PMA was observed in resident macrophages after a 48-h incubation with IFN-gamma, TNF-alpha, TNF-beta, or CSF-GM.	Tetradecanoylphorbol Acetate	37-40	lymphotoxin A	Mus musculus	129-137
2174010-7	1990	On the contrary, P20 and P47 phosphorylation induced by 50 nM of 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C, was significantly decreased in the DM-A group.	Tetradecanoylphorbol Acetate	65-101	pleckstrin	Homo sapiens	25-28
2174010-7	1990	On the contrary, P20 and P47 phosphorylation induced by 50 nM of 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C, was significantly decreased in the DM-A group.	Tetradecanoylphorbol Acetate	65-101	major histocompatibility complex, class II, DM alpha	Homo sapiens	172-176
1979333-6	1990	Since defective anti-CD2-induced mitogenesis could be reversed by phorbol myristate acetate, but not calcium ionophore A23187, it is probably correlated with impaired protein kinase C activation.	Tetradecanoylphorbol Acetate	66-91	CD2 molecule	Homo sapiens	21-24
3152600-8	1988	The extent and kinetics of c-myc oncoprotein induction have been determined following phorbol ester, 12-O tetradecanoylphorbol 13 acetate (TPA) and interferon-gamma (IFN-gamma) exposure of both HL-60 and Daudi cells.	Tetradecanoylphorbol Acetate	101-137	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	27-32
3152600-8	1988	The extent and kinetics of c-myc oncoprotein induction have been determined following phorbol ester, 12-O tetradecanoylphorbol 13 acetate (TPA) and interferon-gamma (IFN-gamma) exposure of both HL-60 and Daudi cells.	Tetradecanoylphorbol Acetate	139-142	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	27-32
3152600-9	1988	TPA produced a gradual reduction in the level of c-myc protein and arrested the cells in G0/G1 phase in HL-60 cells.	Tetradecanoylphorbol Acetate	0-3	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	49-54
8391878-1	1993	Hepatocyte growth factor (HGF) secreted from human promyelocytic leukemia cell line, HL-60, is indistinguishable from HGF in human plasma and its release is significantly stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), a differentiation-inducer of HL-60 cells into monocytes/macrophages (Nishino T et al: Biochem Biophys Res Commun 181:323, 1991).	Tetradecanoylphorbol Acetate	185-221	hepatocyte growth factor	Homo sapiens	0-24
8391878-1	1993	Hepatocyte growth factor (HGF) secreted from human promyelocytic leukemia cell line, HL-60, is indistinguishable from HGF in human plasma and its release is significantly stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), a differentiation-inducer of HL-60 cells into monocytes/macrophages (Nishino T et al: Biochem Biophys Res Commun 181:323, 1991).	Tetradecanoylphorbol Acetate	185-221	hepatocyte growth factor	Homo sapiens	26-29
8391878-1	1993	Hepatocyte growth factor (HGF) secreted from human promyelocytic leukemia cell line, HL-60, is indistinguishable from HGF in human plasma and its release is significantly stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), a differentiation-inducer of HL-60 cells into monocytes/macrophages (Nishino T et al: Biochem Biophys Res Commun 181:323, 1991).	Tetradecanoylphorbol Acetate	185-221	hepatocyte growth factor	Homo sapiens	118-121
2901964-6	1988	We also report here that cAMP does inhibit the CD2-induced proliferation in a dose-dependent manner while the proliferation generated independently of DG and IP production by a combination of Ca2+ ionophore A23187 and 12-O-tetradecanoylphorbol 13-acetate is not affected.	Tetradecanoylphorbol Acetate	218-254	CD2 molecule	Homo sapiens	47-50
2242424-7	1990	In another patient with myelofibrosis and defective aggregation, PAC1 failed to bind to adenosine diphosphate-stimulated platelets, but did bind when protein kinase C was directly activated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	195-220	ADCYAP receptor type I	Homo sapiens	65-69
8391878-1	1993	Hepatocyte growth factor (HGF) secreted from human promyelocytic leukemia cell line, HL-60, is indistinguishable from HGF in human plasma and its release is significantly stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), a differentiation-inducer of HL-60 cells into monocytes/macrophages (Nishino T et al: Biochem Biophys Res Commun 181:323, 1991).	Tetradecanoylphorbol Acetate	223-226	hepatocyte growth factor	Homo sapiens	0-24
8391878-1	1993	Hepatocyte growth factor (HGF) secreted from human promyelocytic leukemia cell line, HL-60, is indistinguishable from HGF in human plasma and its release is significantly stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), a differentiation-inducer of HL-60 cells into monocytes/macrophages (Nishino T et al: Biochem Biophys Res Commun 181:323, 1991).	Tetradecanoylphorbol Acetate	223-226	hepatocyte growth factor	Homo sapiens	26-29
3139787-1	1988	We have reported that human interferon-gamma (IFN-gamma) genomic DNA is expressed after transfection into a mouse T-lymphoblastoid cell line and expression can be enhanced by both interleukin 2 (IL2) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	231-234	interleukin 2	Mus musculus	180-193
3139787-1	1988	We have reported that human interferon-gamma (IFN-gamma) genomic DNA is expressed after transfection into a mouse T-lymphoblastoid cell line and expression can be enhanced by both interleukin 2 (IL2) and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	231-234	interleukin 2	Mus musculus	195-198
8391878-2	1993	TPA stimulated HGF release from the cells through an activation of C-kinase, but not through a formation of reactive oxygen species.	Tetradecanoylphorbol Acetate	0-3	hepatocyte growth factor	Homo sapiens	15-18
1977836-12	1990	In summary, we have identified two CD18-independent mechanisms of monocyte adherence to HUVE; a PMA-sensitive mechanism mediating basal adherence and a PMA-insensitive mechanism involved in binding to E-LAMs.	Tetradecanoylphorbol Acetate	96-99	lymphotoxin beta receptor	Homo sapiens	35-39
8391878-4	1993	1,25-Dihydroxyvitamin D3, another monocyte/macrophage-inducer, abated either TPA- or dbcAMP-stimulated synthesis and release of HGF in a dose-dependent manner probably via its nuclear receptor as reflected by vitamin D analog study.	Tetradecanoylphorbol Acetate	77-80	hepatocyte growth factor	Homo sapiens	128-131
8508699-5	1993	Activation of protein kinase C by phorbol 12-myristate 13-acetate, on the other hand, increased mucin secretion by a compound exocytotic pathway.	Tetradecanoylphorbol Acetate	34-65	LOC100508689	Homo sapiens	96-101
2173584-6	1990	The results thus indicate that, in GH4C1 cells, hyperosmotic stress in combination with TRH or TPA can activate Na+/H+ exchange at resting pHi levels.	Tetradecanoylphorbol Acetate	95-98	glucose-6-phosphate isomerase	Rattus norvegicus	139-142
2463477-5	1988	Both G- and GM-CSF mRNA concentrations coordinately increased after exposure of the cells to TNF alpha (greater than or equal to 5 ng/ml), 12-O-tetradecanoylphorbol 13-acetate (TPA) (greater than or equal to 5 x 10(-10) M), or cycloheximide (20 micrograms/ml).	Tetradecanoylphorbol Acetate	139-175	colony stimulating factor 2	Homo sapiens	12-18
2463477-5	1988	Both G- and GM-CSF mRNA concentrations coordinately increased after exposure of the cells to TNF alpha (greater than or equal to 5 ng/ml), 12-O-tetradecanoylphorbol 13-acetate (TPA) (greater than or equal to 5 x 10(-10) M), or cycloheximide (20 micrograms/ml).	Tetradecanoylphorbol Acetate	177-180	colony stimulating factor 2	Homo sapiens	12-18
2463477-6	1988	Both TNF alpha and TPA increased levels of G- and GM-CSF mRNA in the absence of new protein synthesis.	Tetradecanoylphorbol Acetate	19-22	colony stimulating factor 2	Homo sapiens	50-56
2463477-7	1988	Transcriptional run-on studies demonstrated that fibroblasts constitutively transcribed GM-CSF, and transcription was enhanced 3.0-fold by TNF alpha and 2.5-fold by TPA and was unchanged by cycloheximide.	Tetradecanoylphorbol Acetate	165-168	colony stimulating factor 2	Homo sapiens	88-94
8101652-6	1993	Furthermore, we have observed that the expression of three HOX 1 genes within B lymphoid lineages is stage-related and that the expression of several of them is switched off during TPA-induced differentiation of KG1 and U937 cells.	Tetradecanoylphorbol Acetate	181-184	homeobox A cluster	Homo sapiens	59-64
2899916-7	1988	Both 8-BrcAMP and TPA stimulated gastrin release in a dose-dependent fashion.	Tetradecanoylphorbol Acetate	18-21	gastrin	Homo sapiens	33-40
1700699-5	1990	Treatment of AML 193 cells with phorbol myristate acetate resulted in serine phosphorylation of p68; however, p140 was not phosphorylated on tyrosine.	Tetradecanoylphorbol Acetate	32-57	DNA polymerase delta 3, accessory subunit	Homo sapiens	96-99
1700699-6	1990	Depletion of protein kinase C isoenzymes with high concentrations of phorbol myristate acetate resulted in p68 phosphorylation, which was not further increased by IL 3 or GM-CSF.	Tetradecanoylphorbol Acetate	69-94	DNA polymerase delta 3, accessory subunit	Homo sapiens	107-110
2121048-4	1990	Actinomycin D and cycloheximide blocked the PMA-stimulated COX activity but not AA release.	Tetradecanoylphorbol Acetate	44-47	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	59-62
2838469-4	1988	The induction of TcR-alpha and -delta mRNA by 12-O-tetradecanoylphorbol-13-acetate occurred at the transcriptional level only whereas cAMP treatment decreased both TcR-alpha gene transcription and the stability of its mRNA.	Tetradecanoylphorbol Acetate	46-82	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	17-20
8503930-1	1993	The effect of transforming growth factor-beta (TGF-beta) on the endogenous protein phosphorylation caused by phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC), was examined in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	109-140	transforming growth factor, beta 1	Mus musculus	47-55
8503930-1	1993	The effect of transforming growth factor-beta (TGF-beta) on the endogenous protein phosphorylation caused by phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC), was examined in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	142-145	transforming growth factor, beta 1	Mus musculus	47-55
3142093-5	1988	Cells that were induced with PMA but not with RA or DMF also produced an inhibitor to UK that was identified as PAI-2, the plasminogen activator inhibitor that is produced by monocytes.	Tetradecanoylphorbol Acetate	29-32	serpin family B member 2	Homo sapiens	112-117
8503930-3	1993	TGF-beta strongly suppressed the PMA-stimulated phosphorylation of these three proteins.	Tetradecanoylphorbol Acetate	33-36	transforming growth factor, beta 1	Mus musculus	0-8
8486654-3	1993	A single 1.3-kilobase macrosialin transcript was detected in both untreated and phorbol 12-myristate 13-acetate-stimulated RAW cells.	Tetradecanoylphorbol Acetate	80-111	CD68 antigen	Mus musculus	22-33
2171499-3	1990	Both the Ca2+ ionophore ionomycin and the tumour promotor tetradecanoylphorbol acetate (TPA), added shortly before EGF, inhibit EGF receptor protein tyrosine kinase activity in intact cells.	Tetradecanoylphorbol Acetate	58-86	epidermal growth factor	Homo sapiens	115-118
2171499-3	1990	Both the Ca2+ ionophore ionomycin and the tumour promotor tetradecanoylphorbol acetate (TPA), added shortly before EGF, inhibit EGF receptor protein tyrosine kinase activity in intact cells.	Tetradecanoylphorbol Acetate	88-91	epidermal growth factor	Homo sapiens	115-118
8324074-0	1993	Induction of interleukin-2 receptor alpha-chain gene expression by cytochalasin B and 12-O-tetradecanoylphorbol-13-acetate in T lymphocytes.	Tetradecanoylphorbol Acetate	86-122	interleukin 2 receptor subunit alpha	Homo sapiens	13-41
8324074-4	1993	In this study, we examined the effect of cytochalasin B (CB) plus 12-O-tetradecanoylphorbol-13-acetate (TPA) on expression of IL-2 and IL-2R.	Tetradecanoylphorbol Acetate	66-102	interleukin 2 receptor subunit alpha	Homo sapiens	135-140
2133217-5	1990	Phorbol myristate acetate can inhibit as well as induce tissue factor activity in monocytes, whereas phorbol myristate acetate only induces the expression of tissue factor in endothelial cells.	Tetradecanoylphorbol Acetate	0-25	coagulation factor III, tissue factor	Homo sapiens	56-69
8324074-4	1993	In this study, we examined the effect of cytochalasin B (CB) plus 12-O-tetradecanoylphorbol-13-acetate (TPA) on expression of IL-2 and IL-2R.	Tetradecanoylphorbol Acetate	104-107	interleukin 2 receptor subunit alpha	Homo sapiens	135-140
2133217-5	1990	Phorbol myristate acetate can inhibit as well as induce tissue factor activity in monocytes, whereas phorbol myristate acetate only induces the expression of tissue factor in endothelial cells.	Tetradecanoylphorbol Acetate	101-126	coagulation factor III, tissue factor	Homo sapiens	158-171
8324074-7	1993	Unlike the cells treated individually with CB or TPA, cells treated with CB plus TPA accumulated IL-2R mRNA at all the times examined.	Tetradecanoylphorbol Acetate	81-84	interleukin 2 receptor subunit alpha	Homo sapiens	97-102
2283681-5	1990	Low concentrations of TPA (2 x 10(-10) M) had no effect on Ca2+ release due to EGF, TGR-alpha or bradykinin but resulted in a rapid return of [Ca2+]i to baseline levels for EGF or TGF-alpha.	Tetradecanoylphorbol Acetate	22-25	epidermal growth factor	Homo sapiens	173-176
8389299-9	1993	Prior incubation of Hep G2 cells with LDL in the presence of PMA led to a 2.3-fold increase of intracellular cholesteryl esters and a 9.1-fold increase in acyl-CoA:cholesterol-acyltransferase (ACAT) activity.	Tetradecanoylphorbol Acetate	61-64	sterol O-acyltransferase 1	Homo sapiens	155-191
2118993-5	1990	However, the induction of fos, jun, and myc by EGF and TPA was not significantly inhibited in this cell line.	Tetradecanoylphorbol Acetate	55-58	FBJ osteosarcoma oncogene	Mus musculus	26-29
8389299-9	1993	Prior incubation of Hep G2 cells with LDL in the presence of PMA led to a 2.3-fold increase of intracellular cholesteryl esters and a 9.1-fold increase in acyl-CoA:cholesterol-acyltransferase (ACAT) activity.	Tetradecanoylphorbol Acetate	61-64	sterol O-acyltransferase 1	Homo sapiens	193-197
8477800-5	1993	We found that CD69 is induced on NK cells not only by IL-2 and IFN-alpha but also by activation of the CD16 pathway, the interaction with NK target cells and the direct activation of PKC by phorbol 12-myristate 13-acetate (PMA), indicating that CD69 induction is associated to different NK activation pathways.	Tetradecanoylphorbol Acetate	190-221	CD69 molecule	Homo sapiens	14-18
2241900-1	1990	Short-term treatment of rat basophilic leukaemia (RBL-2H3) cells with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) activates protein kinase C (PKC) and results in the inhibition of the IgE-dependent formation of inositol phosphates, but in the potentiation of serotonin secretion.	Tetradecanoylphorbol Acetate	88-124	plasminogen activator, tissue type	Rattus norvegicus	126-129
8477800-5	1993	We found that CD69 is induced on NK cells not only by IL-2 and IFN-alpha but also by activation of the CD16 pathway, the interaction with NK target cells and the direct activation of PKC by phorbol 12-myristate 13-acetate (PMA), indicating that CD69 induction is associated to different NK activation pathways.	Tetradecanoylphorbol Acetate	223-226	CD69 molecule	Homo sapiens	14-18
8477800-6	1993	The treatment with the PKC inhibitor staurosporine abolished the induction of CD69 induced by PMA or K562.	Tetradecanoylphorbol Acetate	94-97	CD69 molecule	Homo sapiens	78-82
2168226-3	1990	Concentrations of H7 and H8 that inhibited the 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulated upregulation of CD11b expression and activation of the respiratory burst, both augmented the effects of GM-CSF.	Tetradecanoylphorbol Acetate	47-84	colony stimulating factor 2	Homo sapiens	206-212
2168226-3	1990	Concentrations of H7 and H8 that inhibited the 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulated upregulation of CD11b expression and activation of the respiratory burst, both augmented the effects of GM-CSF.	Tetradecanoylphorbol Acetate	86-89	colony stimulating factor 2	Homo sapiens	206-212
8455941-5	1993	Moreover, whereas both Tax and phorbol 12-myristate 13-acetate (PMA) are able to efficiently induce the binding of NF-kappa B to the IL-2R alpha kappa B site, PMA is functionally inactive.	Tetradecanoylphorbol Acetate	31-62	interleukin 2 receptor subunit alpha	Homo sapiens	133-144
8455941-5	1993	Moreover, whereas both Tax and phorbol 12-myristate 13-acetate (PMA) are able to efficiently induce the binding of NF-kappa B to the IL-2R alpha kappa B site, PMA is functionally inactive.	Tetradecanoylphorbol Acetate	64-67	interleukin 2 receptor subunit alpha	Homo sapiens	133-144
8449903-8	1993	Dexamethasone blocked both the TPA- and serum-induced appearance of TIS10/PGS-2 antigen.	Tetradecanoylphorbol Acetate	31-34	prostaglandin-endoperoxide synthase 2	Mus musculus	68-73
2206949-3	1990	Phorbol 12-tetradecanoate-13-acetate (TPA) and the TPA-type tumour promoters, aplysiatoxin and debromoaplysiatoxin, inhibited the growth of the two parental cell lines, K562 and PC-9.	Tetradecanoylphorbol Acetate	0-36	proprotein convertase subtilisin/kexin type 9	Homo sapiens	178-182
2206949-3	1990	Phorbol 12-tetradecanoate-13-acetate (TPA) and the TPA-type tumour promoters, aplysiatoxin and debromoaplysiatoxin, inhibited the growth of the two parental cell lines, K562 and PC-9.	Tetradecanoylphorbol Acetate	38-41	proprotein convertase subtilisin/kexin type 9	Homo sapiens	178-182
8449903-8	1993	Dexamethasone blocked both the TPA- and serum-induced appearance of TIS10/PGS-2 antigen.	Tetradecanoylphorbol Acetate	31-34	decorin	Mus musculus	74-79
8444879-0	1993	Human T cell leukemia virus type I Tax and phorbol 12-myristate 13-acetate induce expression of the A20 zinc finger protein by distinct mechanisms involving nuclear factor kappa B.	Tetradecanoylphorbol Acetate	43-74	TNF alpha induced protein 3	Homo sapiens	100-103
8439961-4	1993	Exposure of UT-7 to the tumor promoter, phorbol myristate acetate (PMA), resulted in the appearance of mature megakaryocytic properties, including the expression of platelet factor 4 and beta-thromboglobulin.	Tetradecanoylphorbol Acetate	40-65	pro-platelet basic protein	Homo sapiens	187-207
8439961-4	1993	Exposure of UT-7 to the tumor promoter, phorbol myristate acetate (PMA), resulted in the appearance of mature megakaryocytic properties, including the expression of platelet factor 4 and beta-thromboglobulin.	Tetradecanoylphorbol Acetate	67-70	pro-platelet basic protein	Homo sapiens	187-207
2167156-5	1990	A high level of expression of interstitial collagenase message was found in human A2058 melanoma cells by Northern blot analysis, and this level was slightly increased by phorbol ester (phorbol myristate acetate) stimulation.	Tetradecanoylphorbol Acetate	186-211	matrix metallopeptidase 1	Homo sapiens	30-54
8436593-5	1993	In mRNA decay studies, phorbol esters caused a selective 6-fold increase in the half-life of the GAP-43 mRNA, which accounts for most of the induction of this mRNA by TPA.	Tetradecanoylphorbol Acetate	167-170	growth associated protein 43	Rattus norvegicus	97-103
8436593-7	1993	In contrast, the rates of degradation and the levels of the GAP-43 mRNA in control and TPA-treated cells were not affected by cycloheximide treatment.	Tetradecanoylphorbol Acetate	87-90	growth associated protein 43	Rattus norvegicus	60-66
8380584-4	1993	On the other hand, TPA treatment induced the phosphorylation and translocation of myristoylated alanine-rich C kinase substrate (MARCKS) from the membrane to the cytosol.	Tetradecanoylphorbol Acetate	19-22	myristoylated alanine rich protein kinase C substrate	Homo sapiens	82-127
2201751-2	1990	This cDNA was used to clone cDNAs for human homologues of MIP-2 from a library prepared from phorbol myristate acetate-treated and LPS-stimulated U937 cells.	Tetradecanoylphorbol Acetate	93-118	C-X-C motif chemokine ligand 2	Homo sapiens	58-63
8380584-4	1993	On the other hand, TPA treatment induced the phosphorylation and translocation of myristoylated alanine-rich C kinase substrate (MARCKS) from the membrane to the cytosol.	Tetradecanoylphorbol Acetate	19-22	myristoylated alanine rich protein kinase C substrate	Homo sapiens	129-135
8381593-8	1993	At 6 h of treatment, both TPA- and 8-BrcAMP-treated cultures showed markedly elevated levels of connexin43, whereas at 24 h, the level of connexin43 in TPA-treated cultures had returned to control levels.	Tetradecanoylphorbol Acetate	26-29	gap junction protein alpha 1	Homo sapiens	96-106
2143806-1	1990	The products of the Jun and Fos proto-oncogenes form a heterodimer that binds to and activates transcription from 12-O-tetradecanoylphorbol-13-acetate-responsive promoter elements (TGACTCA) and AP-1-binding sites (TGACATCA).	Tetradecanoylphorbol Acetate	114-150	FBJ osteosarcoma oncogene	Mus musculus	28-31
8381593-8	1993	At 6 h of treatment, both TPA- and 8-BrcAMP-treated cultures showed markedly elevated levels of connexin43, whereas at 24 h, the level of connexin43 in TPA-treated cultures had returned to control levels.	Tetradecanoylphorbol Acetate	152-155	gap junction protein alpha 1	Homo sapiens	138-148
8419187-4	1993	After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells.	Tetradecanoylphorbol Acetate	23-54	interleukin 5	Homo sapiens	156-160
8419187-4	1993	After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells.	Tetradecanoylphorbol Acetate	56-59	interleukin 5	Homo sapiens	156-160
2117917-3	1990	We report here that the protein kinase C inhibitor staurosporine enhanced the IL-1 alpha-induced increase in [Fru(2,6)P2] and PGE production by RSC, whereas in similar concentrations (3-30 nM) this inhibitor decreased the TPA-induced stimulation of these parameters.	Tetradecanoylphorbol Acetate	222-225	interleukin 1 alpha	Homo sapiens	78-88
8499771-0	1993	CD23/Fc epsilon RII expression on phytohemagglutinin-A- or phorbol-12myristate-13acetate-Ca(2+)-activated human tonsil T cells.	Tetradecanoylphorbol Acetate	59-88	Fc epsilon receptor II	Homo sapiens	0-4
2170797-8	1990	In vitro perfusion of hypothalamic fragments with PMA and/or FKN stimulated LHRH release as well as LHRH mRNA.	Tetradecanoylphorbol Acetate	50-53	gonadotropin releasing hormone 1	Rattus norvegicus	76-80
2170797-8	1990	In vitro perfusion of hypothalamic fragments with PMA and/or FKN stimulated LHRH release as well as LHRH mRNA.	Tetradecanoylphorbol Acetate	50-53	gonadotropin releasing hormone 1	Rattus norvegicus	100-104
8499771-0	1993	CD23/Fc epsilon RII expression on phytohemagglutinin-A- or phorbol-12myristate-13acetate-Ca(2+)-activated human tonsil T cells.	Tetradecanoylphorbol Acetate	59-88	Fc epsilon receptor II	Homo sapiens	5-19
2170797-9	1990	The combined infusion of FKN and PMA did not produce an additive effect on the LHRH mRNA levels, but it was effective in synergistically increasing LHRH secretion in vitro.	Tetradecanoylphorbol Acetate	33-36	gonadotropin releasing hormone 1	Rattus norvegicus	148-152
7678596-0	1993	Protein kinase C beta expression in melanoma cells and melanocytes: differential expression correlates with biological responses to 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	132-168	protein kinase C beta	Homo sapiens	0-21
2151793-1	1990	Treatment of the AML-193 leukemic cell line with phorbol myristate acetate (PMA) resulted in the loss of their ability to proliferate in response to GM-CSF or IL-3.	Tetradecanoylphorbol Acetate	49-74	colony stimulating factor 2	Homo sapiens	149-155
2151793-1	1990	Treatment of the AML-193 leukemic cell line with phorbol myristate acetate (PMA) resulted in the loss of their ability to proliferate in response to GM-CSF or IL-3.	Tetradecanoylphorbol Acetate	49-74	interleukin 3	Homo sapiens	159-163
2151793-1	1990	Treatment of the AML-193 leukemic cell line with phorbol myristate acetate (PMA) resulted in the loss of their ability to proliferate in response to GM-CSF or IL-3.	Tetradecanoylphorbol Acetate	76-79	colony stimulating factor 2	Homo sapiens	149-155
2151793-1	1990	Treatment of the AML-193 leukemic cell line with phorbol myristate acetate (PMA) resulted in the loss of their ability to proliferate in response to GM-CSF or IL-3.	Tetradecanoylphorbol Acetate	76-79	interleukin 3	Homo sapiens	159-163
2142181-0	1990	Human granulocyte-macrophage colony-stimulating factor plus phorbol myristate acetate stimulate a promyelocytic cell line to produce an IL-1 inhibitor.	Tetradecanoylphorbol Acetate	60-85	interleukin 1 receptor antagonist	Homo sapiens	136-150
1971610-4	1990	Forskolin, A23187, and beta-phorbol 12 myristate 13-acetate stimulated basal gastrin secretion from cultured human G cells in a concentration-dependent fashion.	Tetradecanoylphorbol Acetate	23-59	gastrin	Homo sapiens	77-84
1693617-3	1990	The mechanism of TF induction in human umbilical vein endothelial cells (HUVEC) was investigated in response to LPS and phorbol 12-myristate 13-O-acetate (PMA).	Tetradecanoylphorbol Acetate	155-158	coagulation factor III, tissue factor	Homo sapiens	17-19
1693617-4	1990	Northern blot analysis of total RNA from HUVEC showed a rapid rise in TF mRNA levels which was maximal at 2 h and had fallen to low levels by 6 h following both LPS (10 micrograms/ml) and PMA (10 ng/ml) stimulation.	Tetradecanoylphorbol Acetate	188-191	coagulation factor III, tissue factor	Homo sapiens	70-72
2351106-1	1990	Using primary cultures of dispersed rat fetal hypothalami, we studied the effect of forskolin and the phorbol ester 12-o-tetradecanoyl phorbol 13-acetate, activators of protein kinase A and C, respectively, on corticotropin-releasing hormone (CRH) regulation.	Tetradecanoylphorbol Acetate	116-153	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	169-191
1692959-3	1990	Although IL-1 induction of the IL-2 promoter in these cells required costimulus with phorbol myristate acetate, the signal induced by IL-1 was qualitatively different.	Tetradecanoylphorbol Acetate	85-110	interleukin 2	Mus musculus	31-35
2141686-6	1990	It was further demonstrated that the M-CSF (or CSF-1) and c-fms antisense oligomers acted synergistically on inhibition of macrophage formation induced by PMA and hrGM-CSF, but had no inhibitory effect on the macrophage formation induced by 1-alpha-25-(OH)2D3.	Tetradecanoylphorbol Acetate	155-158	colony stimulating factor 1	Homo sapiens	37-42
2141686-6	1990	It was further demonstrated that the M-CSF (or CSF-1) and c-fms antisense oligomers acted synergistically on inhibition of macrophage formation induced by PMA and hrGM-CSF, but had no inhibitory effect on the macrophage formation induced by 1-alpha-25-(OH)2D3.	Tetradecanoylphorbol Acetate	155-158	colony stimulating factor 1	Homo sapiens	47-52
2359619-0	1990	Analysis of the sites in p56lck whose phosphorylation is induced by tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	68-97	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	25-31
2359619-3	1990	We show here that treatment of Jurkat cells with 12-O-tetradecanoyl phorbol-13-acetate also induces threonine phosphorylation of p56lck.	Tetradecanoylphorbol Acetate	49-86	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	129-135
2359619-4	1990	Chymotryptic mapping shows that at least three sites in p56lck undergo phosphorylation in TPA-treated Jurkat cells.	Tetradecanoylphorbol Acetate	90-93	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	56-62
1692028-5	1990	Upon exposure to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), the amount of both vimentin and cytokeratin appeared to be greatly increased within 3 days and was found both in dispersed cytoplasmic fibrils, in large spherical, eccentric aggregates, as well as in cytoplasmic fibrils in cells spreading on fibronectin.	Tetradecanoylphorbol Acetate	35-71	vimentin	Homo sapiens	98-106
1692028-5	1990	Upon exposure to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), the amount of both vimentin and cytokeratin appeared to be greatly increased within 3 days and was found both in dispersed cytoplasmic fibrils, in large spherical, eccentric aggregates, as well as in cytoplasmic fibrils in cells spreading on fibronectin.	Tetradecanoylphorbol Acetate	73-76	vimentin	Homo sapiens	98-106
2182714-4	1990	In our study, it is shown that stimulation of lymphocytes with activators of protein kinase C (PKC), such as PMA or 1-oleoyl 2-acetyl-glycerol, results in the nearly complete loss of surface expression of gp90 within 1 h. Pretreatment of the cells with H-7 or staurosporine, PKC inhibitors, but not HA1004, a general protein kinase inhibitor, prevents the loss of gp90MEL-14.	Tetradecanoylphorbol Acetate	109-112	galectin 3 binding protein	Homo sapiens	205-209
2182714-4	1990	In our study, it is shown that stimulation of lymphocytes with activators of protein kinase C (PKC), such as PMA or 1-oleoyl 2-acetyl-glycerol, results in the nearly complete loss of surface expression of gp90 within 1 h. Pretreatment of the cells with H-7 or staurosporine, PKC inhibitors, but not HA1004, a general protein kinase inhibitor, prevents the loss of gp90MEL-14.	Tetradecanoylphorbol Acetate	109-112	galectin 3 binding protein	Homo sapiens	364-374
1691263-5	1990	The induction of T cell PFP mRNA via CD3, using OKT-3 mAb, was less rapid but greater than that caused by IL-2; however, a combination of PMA and ionomycin, which bypasses crosslinking of the TCR/CD3 complex, could not mimic this increase in PFP mRNA levels in T cells.	Tetradecanoylphorbol Acetate	138-141	perforin 1	Homo sapiens	24-27
1691263-5	1990	The induction of T cell PFP mRNA via CD3, using OKT-3 mAb, was less rapid but greater than that caused by IL-2; however, a combination of PMA and ionomycin, which bypasses crosslinking of the TCR/CD3 complex, could not mimic this increase in PFP mRNA levels in T cells.	Tetradecanoylphorbol Acetate	138-141	perforin 1	Homo sapiens	242-245
2127692-1	1990	We show that in the human T lymphoblastic tumor cell line Molt4 c-myc mRNA and protein expression is down-regulated after exposure to dimethyl sulfoxide, to phorbol myristate acetate, or to the calcium ionophore A23187, which raises the intracellular calcium concentration.	Tetradecanoylphorbol Acetate	157-182	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	64-69
2107490-6	1990	Transcription of the fos, fra-1 and fra-2 genes was induced by phorbol ester (TPA) stimulation of U937 human monocytic cells.	Tetradecanoylphorbol Acetate	78-81	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	26-31
2107490-7	1990	On TPA stimulation, the transcriptions of fos, fra-1 and fra-2 were detectable after 30, 60 and 120 min and maximum after 60, 90 and 240 min, respectively.	Tetradecanoylphorbol Acetate	3-6	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	47-52
2107492-0	1990	2-Aminopurine abolishes EGF- and TPA-stimulated pp33 phosphorylation and c-fos induction without affecting the activation of protein kinase C. Epidermal Growth Factor (EGF) and Tetradecanoyl Phorbol Acetate (TPA) initiate signalling cascades in C3H 10T1/2 fibroblasts by primarily activating distinct protein kinases, the EGF receptor tyrosine kinase and protein kinase C respectively; there is no signal crossover at the initiation of signalling.	Tetradecanoylphorbol Acetate	33-36	epidermal growth factor	Homo sapiens	143-166
2107492-0	1990	2-Aminopurine abolishes EGF- and TPA-stimulated pp33 phosphorylation and c-fos induction without affecting the activation of protein kinase C. Epidermal Growth Factor (EGF) and Tetradecanoyl Phorbol Acetate (TPA) initiate signalling cascades in C3H 10T1/2 fibroblasts by primarily activating distinct protein kinases, the EGF receptor tyrosine kinase and protein kinase C respectively; there is no signal crossover at the initiation of signalling.	Tetradecanoylphorbol Acetate	33-36	epidermal growth factor	Homo sapiens	168-171
2107492-0	1990	2-Aminopurine abolishes EGF- and TPA-stimulated pp33 phosphorylation and c-fos induction without affecting the activation of protein kinase C. Epidermal Growth Factor (EGF) and Tetradecanoyl Phorbol Acetate (TPA) initiate signalling cascades in C3H 10T1/2 fibroblasts by primarily activating distinct protein kinases, the EGF receptor tyrosine kinase and protein kinase C respectively; there is no signal crossover at the initiation of signalling.	Tetradecanoylphorbol Acetate	33-36	epidermal growth factor	Homo sapiens	168-171
2107492-0	1990	2-Aminopurine abolishes EGF- and TPA-stimulated pp33 phosphorylation and c-fos induction without affecting the activation of protein kinase C. Epidermal Growth Factor (EGF) and Tetradecanoyl Phorbol Acetate (TPA) initiate signalling cascades in C3H 10T1/2 fibroblasts by primarily activating distinct protein kinases, the EGF receptor tyrosine kinase and protein kinase C respectively; there is no signal crossover at the initiation of signalling.	Tetradecanoylphorbol Acetate	33-36	ret proto-oncogene	Homo sapiens	326-350
2107492-0	1990	2-Aminopurine abolishes EGF- and TPA-stimulated pp33 phosphorylation and c-fos induction without affecting the activation of protein kinase C. Epidermal Growth Factor (EGF) and Tetradecanoyl Phorbol Acetate (TPA) initiate signalling cascades in C3H 10T1/2 fibroblasts by primarily activating distinct protein kinases, the EGF receptor tyrosine kinase and protein kinase C respectively; there is no signal crossover at the initiation of signalling.	Tetradecanoylphorbol Acetate	177-206	epidermal growth factor	Homo sapiens	24-27
2107492-0	1990	2-Aminopurine abolishes EGF- and TPA-stimulated pp33 phosphorylation and c-fos induction without affecting the activation of protein kinase C. Epidermal Growth Factor (EGF) and Tetradecanoyl Phorbol Acetate (TPA) initiate signalling cascades in C3H 10T1/2 fibroblasts by primarily activating distinct protein kinases, the EGF receptor tyrosine kinase and protein kinase C respectively; there is no signal crossover at the initiation of signalling.	Tetradecanoylphorbol Acetate	208-211	epidermal growth factor	Homo sapiens	24-27
2107492-0	1990	2-Aminopurine abolishes EGF- and TPA-stimulated pp33 phosphorylation and c-fos induction without affecting the activation of protein kinase C. Epidermal Growth Factor (EGF) and Tetradecanoyl Phorbol Acetate (TPA) initiate signalling cascades in C3H 10T1/2 fibroblasts by primarily activating distinct protein kinases, the EGF receptor tyrosine kinase and protein kinase C respectively; there is no signal crossover at the initiation of signalling.	Tetradecanoylphorbol Acetate	208-211	epidermal growth factor	Homo sapiens	143-166
2154454-6	1990	When neutrophils, monocytes, or MDM were stimulated with phorbol 12-myristate 13-acetate or opsonized zymosan in the presence of exogenous iron, catalase-inhibitable PBN/.OCH3 was the sole nitroxide detected.	Tetradecanoylphorbol Acetate	57-88	secreted LY6/PLAUR domain containing 1	Homo sapiens	32-35
2310382-12	1990	Pretreatment of platelets with forskolin or phorbol 12-myristate 13-acetate (PMA) decreased cathepsin G binding by approx.	Tetradecanoylphorbol Acetate	44-75	cathepsin G	Homo sapiens	92-103
2310382-12	1990	Pretreatment of platelets with forskolin or phorbol 12-myristate 13-acetate (PMA) decreased cathepsin G binding by approx.	Tetradecanoylphorbol Acetate	77-80	cathepsin G	Homo sapiens	92-103
1967276-5	1990	When murine T lymphocytes were treated with PI-PLC and then stimulated with either Con A, the calcium ionophore A23187 and PMA, or an anti-CD3 mAb, the response to Con A stimulation was inhibited by 90%, whereas the responses to ionophore and PMA or anti-CD3 were not affected.	Tetradecanoylphorbol Acetate	123-126	protein disulfide isomerase associated 3	Mus musculus	44-50
1967276-5	1990	When murine T lymphocytes were treated with PI-PLC and then stimulated with either Con A, the calcium ionophore A23187 and PMA, or an anti-CD3 mAb, the response to Con A stimulation was inhibited by 90%, whereas the responses to ionophore and PMA or anti-CD3 were not affected.	Tetradecanoylphorbol Acetate	243-246	protein disulfide isomerase associated 3	Mus musculus	44-50
2295643-2	1990	Previous experiments had demonstrated that cathepsin G is actively produced by the promonocytic U937 cell line, and that 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of these cells toward macrophages resulted in a reduction of cathepsin G activity.	Tetradecanoylphorbol Acetate	121-157	cathepsin G	Homo sapiens	43-54
2295643-2	1990	Previous experiments had demonstrated that cathepsin G is actively produced by the promonocytic U937 cell line, and that 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of these cells toward macrophages resulted in a reduction of cathepsin G activity.	Tetradecanoylphorbol Acetate	121-157	cathepsin G	Homo sapiens	249-260
2295643-2	1990	Previous experiments had demonstrated that cathepsin G is actively produced by the promonocytic U937 cell line, and that 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of these cells toward macrophages resulted in a reduction of cathepsin G activity.	Tetradecanoylphorbol Acetate	159-162	cathepsin G	Homo sapiens	43-54
2295643-2	1990	Previous experiments had demonstrated that cathepsin G is actively produced by the promonocytic U937 cell line, and that 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of these cells toward macrophages resulted in a reduction of cathepsin G activity.	Tetradecanoylphorbol Acetate	159-162	cathepsin G	Homo sapiens	249-260
2153119-9	1990	Concomitantly, SOC I activity appeared in the plasma membranes of PMA-treated cells.	Tetradecanoylphorbol Acetate	66-69	UBX domain protein 11	Homo sapiens	15-20
2295614-9	1990	Following stimulation of intact neutrophils with phorbol 12-myristate 13-acetate complete loss of native cytosolic kinase activity was observed, with recovery of approximately 30% of the original activity as a cytosolic Ca+/phospholipid independent form, presumably PKM.	Tetradecanoylphorbol Acetate	49-80	pyruvate kinase M1/2	Homo sapiens	266-269
1966814-5	1990	In search of a mechanism for oxidative priming by PAF, we investigated the role of PAF in modifying PMA-induced activation/translocation of protein kinase C (PKC) in human neutrophils.	Tetradecanoylphorbol Acetate	100-103	PCNA clamp associated factor	Homo sapiens	83-86
1966814-6	1990	In the presence of PAF and PMA both PKC and calcium-, phospholipid-independent protein kinase activities in particulate fractions increase markedly over activities detected in the presence of PMA alone.	Tetradecanoylphorbol Acetate	192-195	PCNA clamp associated factor	Homo sapiens	19-22
2133285-10	1990	PBM primed with PAF respond by secreting TNF to both phorbol myristate acetate and concanavalin A but respond poorly to PAF, LPS, or IFN-gamma.	Tetradecanoylphorbol Acetate	53-78	PCNA clamp associated factor	Homo sapiens	16-19
2134691-8	1990	In contrast, pretreatment of the animals with the tumor promoter tetradecanoyl phorbol acetate (TPA) led to the formation of sizeable amounts of non-cytochrome P-450-dependent adducts following coincident administration of (+)-BP-7,8-diol with a second dose of TPA.	Tetradecanoylphorbol Acetate	65-94	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	149-165
2134691-8	1990	In contrast, pretreatment of the animals with the tumor promoter tetradecanoyl phorbol acetate (TPA) led to the formation of sizeable amounts of non-cytochrome P-450-dependent adducts following coincident administration of (+)-BP-7,8-diol with a second dose of TPA.	Tetradecanoylphorbol Acetate	96-99	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	149-165
20702194-1	1990	Certain sublines of EL-4 thymoma cells can be stimulated to produce interleukin-2 (IL-2) by the mitogens phorbol-12-myristate-13-acetate and concanavalin A. EL-4 cells were cultured under conditions found to be most effective for stimulating the release of IL-2 into the culture medium.	Tetradecanoylphorbol Acetate	105-136	interleukin 2	Mus musculus	68-81
20702194-1	1990	Certain sublines of EL-4 thymoma cells can be stimulated to produce interleukin-2 (IL-2) by the mitogens phorbol-12-myristate-13-acetate and concanavalin A. EL-4 cells were cultured under conditions found to be most effective for stimulating the release of IL-2 into the culture medium.	Tetradecanoylphorbol Acetate	105-136	interleukin 2	Mus musculus	83-87
33772987-3	2021	We performed a systematic review and meta-analysis of the efficacy and safety of IV tPA compared with normal saline, placebo, or no treatment in patients with WUS using imaging-based treatment algorithms.	Tetradecanoylphorbol Acetate	84-87	DnaJ heat shock protein family (Hsp40) member C22	Homo sapiens	159-162
33772987-5	2021	We included controlled trials (randomized or nonrandomized), observational cohort studies (prospective or retrospective), and single-arm studies in which adults with WUS were administered IV tPA after MR- or CT-based imaging.	Tetradecanoylphorbol Acetate	191-194	DnaJ heat shock protein family (Hsp40) member C22	Homo sapiens	166-169
11222479-3	2001	This study investigates the effect of interferon (IFN)-gamma on VLDL receptor expression in phorbol-12-myristate-13-acetate (PMA)-treated THP-1, HL-60 macrophages, and human monocyte-derived macrophages.	Tetradecanoylphorbol Acetate	92-123	very low density lipoprotein receptor	Homo sapiens	64-77
11222479-3	2001	This study investigates the effect of interferon (IFN)-gamma on VLDL receptor expression in phorbol-12-myristate-13-acetate (PMA)-treated THP-1, HL-60 macrophages, and human monocyte-derived macrophages.	Tetradecanoylphorbol Acetate	125-128	very low density lipoprotein receptor	Homo sapiens	64-77
11222479-7	2001	In THP-1 macrophages, VLDL receptor protein expression decreased at 2 days after PMA treatment but increased at 3 days and increased up to 5 days.	Tetradecanoylphorbol Acetate	81-84	very low density lipoprotein receptor	Homo sapiens	22-35
8570188-4	1995	Transient transfection of MAPK phosphatase-1 (MKP-1), a protein phosphatase which preferentially dephosphorylates and inactivates MAPK, inhibited the functional effects of both PMA and the constitutively active MEK1 mutants.	Tetradecanoylphorbol Acetate	177-180	mitogen-activated protein kinase kinase 1	Homo sapiens	211-215
7527355-1	1994	The tumour promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) causes changes in epidermal protein expression, especially in the major differentiation products keratins K1 and K10.	Tetradecanoylphorbol Acetate	20-57	keratin 1	Mus musculus	170-180
7527355-1	1994	The tumour promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) causes changes in epidermal protein expression, especially in the major differentiation products keratins K1 and K10.	Tetradecanoylphorbol Acetate	59-62	keratin 1	Mus musculus	170-180
7527355-5	1994	Both cantharidin- and TPA-treated epidermis displayed altered distributions of K1 and K10 with expression only in the outermost cell layers, but the start of their postreplicative expression paralleled that in normal epidermis (18 h for K1 and 24 h for K10 after the last round of DNA synthesis).	Tetradecanoylphorbol Acetate	22-25	keratin 1	Mus musculus	79-89
7527355-5	1994	Both cantharidin- and TPA-treated epidermis displayed altered distributions of K1 and K10 with expression only in the outermost cell layers, but the start of their postreplicative expression paralleled that in normal epidermis (18 h for K1 and 24 h for K10 after the last round of DNA synthesis).	Tetradecanoylphorbol Acetate	22-25	keratin 1	Mus musculus	237-246
34903321-6	2022	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) changed the expression levels of EMT markers, increasing alpha-SMA, vimentin, and MMP-9 expression and decreasing E-cadherin expression, with changes in cell morphology.	Tetradecanoylphorbol Acetate	15-51	vimentin	Homo sapiens	126-134
34903321-6	2022	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) changed the expression levels of EMT markers, increasing alpha-SMA, vimentin, and MMP-9 expression and decreasing E-cadherin expression, with changes in cell morphology.	Tetradecanoylphorbol Acetate	53-56	vimentin	Homo sapiens	126-134
34903321-9	2022	Inhibition of aurora kinase A blocked TPA-induced vimentin and MMP-9 expression, and decreased E-cadherin expression.	Tetradecanoylphorbol Acetate	38-41	vimentin	Homo sapiens	50-58
34780714-5	2022	Although mRNA levels of inflammatory cytokines in skin after topical application of 12-O-tetradecanoylphorbol-13-acetate or imiquimod were comparable between kCYC+/- and wild-type mice, protein levels of inflammatory cytokines such as interleukin (IL)-17A, IL-22, and IL-23 were significantly upregulated in kCYC+/- mice in both models.	Tetradecanoylphorbol Acetate	84-120	interleukin 22	Mus musculus	257-262
3390175-0	1988	Effect of tumor promoting phorbol ester TPA on epidermal protein synthesis: stimulation of an elongation factor 2 phosphatase activity by TPA in vivo.	Tetradecanoylphorbol Acetate	40-43	eukaryotic translation elongation factor 2	Mus musculus	94-113
3390175-0	1988	Effect of tumor promoting phorbol ester TPA on epidermal protein synthesis: stimulation of an elongation factor 2 phosphatase activity by TPA in vivo.	Tetradecanoylphorbol Acetate	138-141	eukaryotic translation elongation factor 2	Mus musculus	94-113
3390175-1	1988	Topical application of the phorbol ester TPA to mouse skin causes an increase in the amount of elongation factor 2 (EF-2), a factor in eukaryotic protein synthesis, in the epidermal cytosol (2- to 3-fold) and particulate fraction (7-fold).	Tetradecanoylphorbol Acetate	41-44	eukaryotic translation elongation factor 2	Mus musculus	95-114
3390175-1	1988	Topical application of the phorbol ester TPA to mouse skin causes an increase in the amount of elongation factor 2 (EF-2), a factor in eukaryotic protein synthesis, in the epidermal cytosol (2- to 3-fold) and particulate fraction (7-fold).	Tetradecanoylphorbol Acetate	41-44	eukaryotic translation elongation factor 2	Mus musculus	116-120
3390175-2	1988	Furthermore, as a consequence of this TPA treatment the activity of an epidermal EF-2 phosphatase is stimulated.	Tetradecanoylphorbol Acetate	38-41	eukaryotic translation elongation factor 2	Mus musculus	81-85
3390175-5	1988	Both of the TPA-induced effects result in an increase in unphosphorylated, i.e. active EF-2 and can be suppressed by cyclosporine A.	Tetradecanoylphorbol Acetate	12-15	eukaryotic translation elongation factor 2	Mus musculus	87-91
2835990-3	1988	Inhibition of these functional activities paralleled a decrease in the PMA-induced phosphorylation of the Mr 47,000 substrate (p47) of PKC by pre-incubation of platelets with dibutyryl cAMP.	Tetradecanoylphorbol Acetate	71-74	pleckstrin	Homo sapiens	127-130
2835990-5	1988	The ADP scavenger creatine phosphate/creatine phosphokinase (CP/CPK) and the cyclooxygenase inhibitor indomethacin also diminished the aggregation and p47 phosphorylation responses to PMA or OAG.	Tetradecanoylphorbol Acetate	184-187	pleckstrin	Homo sapiens	151-154
2835990-8	1988	Furthermore, the findings that increased intracellular cAMP inhibits PMA- or OAG-induced p47 phosphorylation in excess of that due solely to CP/CPK, and that cAMP significantly potentiates the effects of ADP removal and inhibition of cyclooxygenase in blocking p47 phosphorylation suggest that cAMP also exerts non-ADP-mediated inhibitory effects on PKC in intact platelets.	Tetradecanoylphorbol Acetate	69-72	pleckstrin	Homo sapiens	89-92
2835990-8	1988	Furthermore, the findings that increased intracellular cAMP inhibits PMA- or OAG-induced p47 phosphorylation in excess of that due solely to CP/CPK, and that cAMP significantly potentiates the effects of ADP removal and inhibition of cyclooxygenase in blocking p47 phosphorylation suggest that cAMP also exerts non-ADP-mediated inhibitory effects on PKC in intact platelets.	Tetradecanoylphorbol Acetate	69-72	pleckstrin	Homo sapiens	261-264
3131020-0	1988	Partial restoration of Con A-induced proliferation, IL-2 receptor expression, and IL-2 synthesis in aged murine lymphocytes by phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	127-152	interleukin 2	Mus musculus	82-86
3136317-1	1988	The tumor promoter phorbol ester (TPA) modulates the binding affinity and the mitogenic capacity of the epidermal growth factor (EGF) receptor.	Tetradecanoylphorbol Acetate	34-37	epidermal growth factor receptor	Mus musculus	104-142
3136317-2	1988	Moreover, TPA-induced kinase C phosphorylation occurs mainly on Thr-654 of the EGF receptor, suggesting that the phosphorylation state of this residue regulates ligand-binding affinity and kinase activity of the EGF receptor.	Tetradecanoylphorbol Acetate	10-13	epidermal growth factor	Mus musculus	79-82
3136317-2	1988	Moreover, TPA-induced kinase C phosphorylation occurs mainly on Thr-654 of the EGF receptor, suggesting that the phosphorylation state of this residue regulates ligand-binding affinity and kinase activity of the EGF receptor.	Tetradecanoylphorbol Acetate	10-13	epidermal growth factor	Mus musculus	212-215
3136317-6	1988	The addition of TPA to NIH 3T3 cells expressing a wild-type human EGF receptor blocked the mitogenic capacity of EGF.	Tetradecanoylphorbol Acetate	16-19	epidermal growth factor	Mus musculus	66-69
3136317-6	1988	The addition of TPA to NIH 3T3 cells expressing a wild-type human EGF receptor blocked the mitogenic capacity of EGF.	Tetradecanoylphorbol Acetate	16-19	epidermal growth factor	Homo sapiens	113-116
3136317-8	1988	In the latter cells, EGF was able to stimulate DNA synthesis even in the presence of inhibitory concentrations of TPA.	Tetradecanoylphorbol Acetate	114-117	epidermal growth factor	Mus musculus	21-24
2899354-7	1988	Antibody L180/1, specific for the T11 (CD2) target structure (T11TS) on SE, homologous to the human CD2 ligand LFA-3, abolished the response to SENAGO alone or when combined with PEG or TPA.	Tetradecanoylphorbol Acetate	186-189	CD2 molecule	Homo sapiens	34-37
2899354-7	1988	Antibody L180/1, specific for the T11 (CD2) target structure (T11TS) on SE, homologous to the human CD2 ligand LFA-3, abolished the response to SENAGO alone or when combined with PEG or TPA.	Tetradecanoylphorbol Acetate	186-189	CD2 molecule	Homo sapiens	39-42
3360806-2	1988	When 32P-labeled human neutrophils were activated by exposure to phorbol myristate acetate, three 48-kDa proteins (designated pp48/6.8, pp48/7.3, and pp48/7.8, from their isoelectric points) were found to have become labeled.	Tetradecanoylphorbol Acetate	65-90	synaptotagmin binding cytoplasmic RNA interacting protein	Homo sapiens	126-134
2454190-1	1988	Pairs of monoclonal antibodies (mAb) defining epitopes T 11.1 and T 11.2 on the CD 2 molecule are mitogenic for purified human T cells in the presence of a submitogenic dose of 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	177-213	CD2 molecule	Homo sapiens	80-84
2454190-1	1988	Pairs of monoclonal antibodies (mAb) defining epitopes T 11.1 and T 11.2 on the CD 2 molecule are mitogenic for purified human T cells in the presence of a submitogenic dose of 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	215-218	CD2 molecule	Homo sapiens	80-84
3259583-3	1988	Using fibroblastic cells depleted of protein kinase C by chronic treatment with the tumor promoter tetradecanoyl phorbol acetate (TPA), we now show that protein kinase C is required for the tyrosine phosphorylation of the 42-kD protein, even when epidermal growth factor (EGF), whose receptor is a tyrosine-specific protein kinase, provides the initial stimulus.	Tetradecanoylphorbol Acetate	99-128	epidermal growth factor	Homo sapiens	247-270
3259583-3	1988	Using fibroblastic cells depleted of protein kinase C by chronic treatment with the tumor promoter tetradecanoyl phorbol acetate (TPA), we now show that protein kinase C is required for the tyrosine phosphorylation of the 42-kD protein, even when epidermal growth factor (EGF), whose receptor is a tyrosine-specific protein kinase, provides the initial stimulus.	Tetradecanoylphorbol Acetate	99-128	epidermal growth factor	Homo sapiens	272-275
3259583-3	1988	Using fibroblastic cells depleted of protein kinase C by chronic treatment with the tumor promoter tetradecanoyl phorbol acetate (TPA), we now show that protein kinase C is required for the tyrosine phosphorylation of the 42-kD protein, even when epidermal growth factor (EGF), whose receptor is a tyrosine-specific protein kinase, provides the initial stimulus.	Tetradecanoylphorbol Acetate	130-133	epidermal growth factor	Homo sapiens	247-270
3259583-3	1988	Using fibroblastic cells depleted of protein kinase C by chronic treatment with the tumor promoter tetradecanoyl phorbol acetate (TPA), we now show that protein kinase C is required for the tyrosine phosphorylation of the 42-kD protein, even when epidermal growth factor (EGF), whose receptor is a tyrosine-specific protein kinase, provides the initial stimulus.	Tetradecanoylphorbol Acetate	130-133	epidermal growth factor	Homo sapiens	272-275
3411820-3	1988	Specific binding of [3H]12-O-tetradecanoylphorbol-13-acetate (TPA) to the particulate fraction of the epidermis of C57BL/6 mice gave a similar dissociation constant (Kd) and a maximal number of binding sites (Bmax) to those of CD-1 mice.	Tetradecanoylphorbol Acetate	62-65	CD1 antigen complex	Mus musculus	227-231
3411820-7	1988	At any doses of TPA, TPA-induced epidermal ODC activity of C57BL/6 mice was always higher than those of SENCAR and CD-1 mice.	Tetradecanoylphorbol Acetate	16-19	CD1 antigen complex	Mus musculus	115-119
3411820-9	1988	These results indicate that the mechanism of the difference in susceptibility of C57BL/6, CD-1 and SENCAR mice to the tumor-promoting action TPA resides in a step distal to or other than the protein kinase C activation and ODC induction.	Tetradecanoylphorbol Acetate	141-144	CD1 antigen complex	Mus musculus	81-94
3260332-1	1988	Following TPA-induced depletion of protein kinase C activity, EGF stimulation of VL30 transcription and accumulation was unaffected while TPA effects were inhibited, implying that EGF and TPA act by separable pathways.	Tetradecanoylphorbol Acetate	10-13	epidermal growth factor	Homo sapiens	180-183
2842906-2	1988	Concanavalin A (Con A) has been found to increase pHi from 7.16 +/- 0.02 to 7.30 +/- 0.02 during the first minutes after addition; the phorbol ester TPA raised pHi to 7.25 +/- 0.02.	Tetradecanoylphorbol Acetate	149-152	glucose-6-phosphate isomerase	Rattus norvegicus	160-163
2842906-3	1988	The Con A- and TPA-induced rise of pHi is due to activation of Na+/H+ exchange since it was abolished by amiloride, an inhibitor of Na+/H+ antiport, or in a low-Na+ medium.	Tetradecanoylphorbol Acetate	15-18	glucose-6-phosphate isomerase	Rattus norvegicus	35-38
2842906-4	1988	The elevation of intracellular cAMP level, decrease of cellular ATP, or the lowering of the temperature from 37 degrees down to 25 degrees C inhibited the pHi rise induced by Con A or TPA.	Tetradecanoylphorbol Acetate	184-187	glucose-6-phosphate isomerase	Rattus norvegicus	155-158
3353368-2	1988	PMA induces translocation of [35S]methionine-prelabeled cytosolic protein kinase C to membranes, followed by complete degradation of the enzyme (t1/2, 2 hr).	Tetradecanoylphorbol Acetate	0-3	CD5 molecule	Homo sapiens	145-152
3342399-2	1988	Promotion-sensitive (P+) JB6 cell variants, from which activated pro-1 and pro-2 were cloned, respond to 12-O-tetradecanoylphorbol-13-acetate (TPA) and various nonphorbol tumor promoters with anchorage-independent transformation that is irreversible 60-80% of the time.	Tetradecanoylphorbol Acetate	105-141	lamin A/C	Homo sapiens	65-70
3342399-2	1988	Promotion-sensitive (P+) JB6 cell variants, from which activated pro-1 and pro-2 were cloned, respond to 12-O-tetradecanoylphorbol-13-acetate (TPA) and various nonphorbol tumor promoters with anchorage-independent transformation that is irreversible 60-80% of the time.	Tetradecanoylphorbol Acetate	143-146	lamin A/C	Homo sapiens	65-70
3342399-10	1988	Finally, assay of the sensitivity of P+ pro-1 and pro-2 transfectants to transformation by TPA at various concentrations showed that transfection with pro-1 or pro-2 conferred about equal responses that were somewhat lower than those observed with parental P+ controls.	Tetradecanoylphorbol Acetate	91-94	lamin A/C	Homo sapiens	40-45
3342399-10	1988	Finally, assay of the sensitivity of P+ pro-1 and pro-2 transfectants to transformation by TPA at various concentrations showed that transfection with pro-1 or pro-2 conferred about equal responses that were somewhat lower than those observed with parental P+ controls.	Tetradecanoylphorbol Acetate	91-94	lamin A/C	Homo sapiens	151-156
2828363-2	1988	The generation of platelet-activating factor (PAF) in response to complement-coated zymosan particles, ionophore A23187 and 12-O-tetradecanoylphorbol 13-acetate (TPA) was studied in human polymorphonuclear leukocytes (PMN).	Tetradecanoylphorbol Acetate	124-160	PCNA clamp associated factor	Homo sapiens	18-44
2828363-2	1988	The generation of platelet-activating factor (PAF) in response to complement-coated zymosan particles, ionophore A23187 and 12-O-tetradecanoylphorbol 13-acetate (TPA) was studied in human polymorphonuclear leukocytes (PMN).	Tetradecanoylphorbol Acetate	124-160	PCNA clamp associated factor	Homo sapiens	46-49
2828363-2	1988	The generation of platelet-activating factor (PAF) in response to complement-coated zymosan particles, ionophore A23187 and 12-O-tetradecanoylphorbol 13-acetate (TPA) was studied in human polymorphonuclear leukocytes (PMN).	Tetradecanoylphorbol Acetate	162-165	PCNA clamp associated factor	Homo sapiens	18-44
2828363-2	1988	The generation of platelet-activating factor (PAF) in response to complement-coated zymosan particles, ionophore A23187 and 12-O-tetradecanoylphorbol 13-acetate (TPA) was studied in human polymorphonuclear leukocytes (PMN).	Tetradecanoylphorbol Acetate	162-165	PCNA clamp associated factor	Homo sapiens	46-49
2828363-3	1988	TPA was an active stimulator of PAF biosynthesis but showed a time course more protracted than that observed in response to other secretagogues.	Tetradecanoylphorbol Acetate	0-3	PCNA clamp associated factor	Homo sapiens	32-35
2893824-11	1988	The expression of TRF/IL-5 mRNA in B151K12 was augmented by the stimulation with PMA plus calcium ionophore.	Tetradecanoylphorbol Acetate	81-84	interleukin 5	Mus musculus	22-26
3422230-1	1988	Treatment of human promyelocytic leukemia cells (HL-60) with phorbol 12-myristate 13-acetate or phorbol 12,13-dibutyrate (PDBu) caused a rapid decrease in transcription of the c-myc protooncogene.	Tetradecanoylphorbol Acetate	61-92	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	176-181
34521919-4	2021	Conversely, the activation of peripheral blood T cells upon PMA/ionomycin stimulation remarkably upregulated KCTD15 and, simultaneously, pIKK-beta and pIKB-alpha.	Tetradecanoylphorbol Acetate	60-63	potassium channel tetramerization domain containing 15	Homo sapiens	109-115
34578957-3	2021	TPA (5 muM) significantly induced cytotoxicity of NHDF, where a robust increase in the interleukin (IL)-1beta mRNA among the various pro-inflammatory cytokines.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 alpha	Homo sapiens	87-109
34578957-4	2021	The skin fibroblastic cytotoxicity and IL-1beta expression induced by TPA were significantly ameliorated by a treatment with 100 nM of kaempferol.	Tetradecanoylphorbol Acetate	70-73	interleukin 1 alpha	Homo sapiens	39-47
34578957-6	2021	Interestingly, we found that kaempferol inhibited the phosphorylation of nuclear factor-kappa B (NF-kappaB) and the inhibitor NF-kappaB (IkappaBalpha), which are necessary for the expression of cleaved caspase-3 and the IL-1beta secretion in TPA-treated NHDF.	Tetradecanoylphorbol Acetate	242-245	interleukin 1 alpha	Homo sapiens	220-228
3257396-10	1988	HH1 (CD37) was expressed by the majority of the cells before TPA treatment and decreased to almost undetectable levels within 24 hours.	Tetradecanoylphorbol Acetate	61-64	CD37 molecule	Homo sapiens	5-9
7678013-3	1993	TPA and 1-oleoyl-2-acetylglycerol also rapidly repress K1 and K10 mRNA expression when added to differentiating keratinocyte cultures already expressing these markers.	Tetradecanoylphorbol Acetate	0-3	endothelin receptor type B modifier 1	Mus musculus	62-65
3257396-13	1988	Taken together these results and previous work on the induction of the protooncogene c-myc and c-fos suggest that this B-CLL clone represents GO cells that undergo differentiation without concomitant proliferation when exposed to TPA.	Tetradecanoylphorbol Acetate	230-233	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	85-90
3345508-0	1988	Induction of ornithine decarboxylase and histidine decarboxylase activities in rat colon mucosa after application of 12-o-tetradecanoylphorbol-13-acetate (TPA), sodium deoxycholate and indole.	Tetradecanoylphorbol Acetate	117-153	ornithine decarboxylase 1	Rattus norvegicus	13-36
3345508-0	1988	Induction of ornithine decarboxylase and histidine decarboxylase activities in rat colon mucosa after application of 12-o-tetradecanoylphorbol-13-acetate (TPA), sodium deoxycholate and indole.	Tetradecanoylphorbol Acetate	155-158	ornithine decarboxylase 1	Rattus norvegicus	13-36
34344445-13	2021	In LP cells, significant induction of Wnt4 and Rankl, and Wnt pathway intermediates Lrp2 and Axin2 (confirmed by qRTPCR) were reversed by TPA and MFP (p < 0.0001).	Tetradecanoylphorbol Acetate	138-141	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	47-52
34344445-13	2021	In LP cells, significant induction of Wnt4 and Rankl, and Wnt pathway intermediates Lrp2 and Axin2 (confirmed by qRTPCR) were reversed by TPA and MFP (p < 0.0001).	Tetradecanoylphorbol Acetate	138-141	low density lipoprotein receptor-related protein 2	Mus musculus	84-88
8352882-8	1993	After treatment with TPA, MEK cultures produced a large induction of both c-jun and c-fos mRNA by 60 min, as determined by northern blot analysis, and a large induction of ODC mRNA and enzyme activity by 6 h. TPA treatment of cultured HEKs, however, did not induce ODC activity; in fact, less activity, compared with that of control cultures, was observed.	Tetradecanoylphorbol Acetate	21-24	ornithine decarboxylase 1	Homo sapiens	172-175
34344445-13	2021	In LP cells, significant induction of Wnt4 and Rankl, and Wnt pathway intermediates Lrp2 and Axin2 (confirmed by qRTPCR) were reversed by TPA and MFP (p < 0.0001).	Tetradecanoylphorbol Acetate	138-141	axin 2	Mus musculus	93-98
3257967-10	1988	Various compounds including interleukin 1, dexamethasone, and phorbol myristate acetate were found to selectively influence the cellular production of one PAI without concomitantly affecting the production of the other, suggesting that the synthesis of these inhibitors is not coordinately regulated.	Tetradecanoylphorbol Acetate	62-87	serpin family E member 1	Homo sapiens	155-158
8352882-8	1993	After treatment with TPA, MEK cultures produced a large induction of both c-jun and c-fos mRNA by 60 min, as determined by northern blot analysis, and a large induction of ODC mRNA and enzyme activity by 6 h. TPA treatment of cultured HEKs, however, did not induce ODC activity; in fact, less activity, compared with that of control cultures, was observed.	Tetradecanoylphorbol Acetate	21-24	ornithine decarboxylase 1	Homo sapiens	265-268
8352882-8	1993	After treatment with TPA, MEK cultures produced a large induction of both c-jun and c-fos mRNA by 60 min, as determined by northern blot analysis, and a large induction of ODC mRNA and enzyme activity by 6 h. TPA treatment of cultured HEKs, however, did not induce ODC activity; in fact, less activity, compared with that of control cultures, was observed.	Tetradecanoylphorbol Acetate	209-212	ornithine decarboxylase 1	Homo sapiens	172-175
34252035-8	2021	PMA also significantly increased NMDAR activity of spinal dorsal horn neurons and the amount of alpha2delta-1-bound GluN1 protein complexes in spinal cord synaptosomes in wild-type mice, but not in alpha2delta-1 knockout mice.	Tetradecanoylphorbol Acetate	0-3	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	116-121
8352882-8	1993	After treatment with TPA, MEK cultures produced a large induction of both c-jun and c-fos mRNA by 60 min, as determined by northern blot analysis, and a large induction of ODC mRNA and enzyme activity by 6 h. TPA treatment of cultured HEKs, however, did not induce ODC activity; in fact, less activity, compared with that of control cultures, was observed.	Tetradecanoylphorbol Acetate	209-212	ornithine decarboxylase 1	Homo sapiens	265-268
3125392-4	1988	p33 phosphorylation is not stimulated by another lymphokine, IL4, nor by TPA or calcium ionophore alone, which are unable to stimulate growth by themselves, and is independent of serum.	Tetradecanoylphorbol Acetate	73-76	lymphotoxin B	Mus musculus	0-3
8352882-11	1993	This suggests that the lack of ODC induction by TPA in HEKs is probably due to species differences in downstream steps in PKC signal transduction.	Tetradecanoylphorbol Acetate	48-51	ornithine decarboxylase 1	Homo sapiens	31-34
34249397-0	2021	Regulatory Effect of Cannabidiol (CBD) on Decreased beta-Catenin Expression in Alopecia Models by Testosterone and PMA Treatment in Dermal Papilla Cells.	Tetradecanoylphorbol Acetate	115-118	catenin beta 1	Homo sapiens	52-64
34249397-7	2021	Consistently, beta-catenin expression was decreased in testosterone or PMA treated dermal papilla cells, suggesting that those treatments are referred as a model on molecular mechanism of alopecia using dermal papilla cells.	Tetradecanoylphorbol Acetate	71-74	catenin beta 1	Homo sapiens	14-26
1458488-3	1992	LIF mRNA expression was enhanced by interleukin 2 or 12-O-tetradecanoylphorbol-13-acetate in MT-2 cells.	Tetradecanoylphorbol Acetate	53-89	LIF interleukin 6 family cytokine	Homo sapiens	0-3
35526705-12	2022	CONCLUSIONS: Combining Mel and Zn supplements with PMA defends against AlCl3-induced AD by modulating GSK-3beta-Wnt/beta-catenin signaling and palliates the associated hepatorenal dysfunction.	Tetradecanoylphorbol Acetate	51-54	catenin beta 1	Rattus norvegicus	116-128
35453810-3	2022	A nonsignificant difference was seen in the CTLA-4 expression on CD3+ T cells compared to the healthy control at basal level and after stimulation with PMA/ionomycin.	Tetradecanoylphorbol Acetate	152-155	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	44-50
35410218-8	2022	Western blot analysis showed that Phorbol-12-Myristate-13-Acetate (TPA) increased B7-H4 expression in a concentration-dependent manner and that rottlerin abrogated the TPA-induced increase in B7-H4 expression.	Tetradecanoylphorbol Acetate	34-65	V-set domain containing T cell activation inhibitor 1	Mus musculus	82-87
35410218-8	2022	Western blot analysis showed that Phorbol-12-Myristate-13-Acetate (TPA) increased B7-H4 expression in a concentration-dependent manner and that rottlerin abrogated the TPA-induced increase in B7-H4 expression.	Tetradecanoylphorbol Acetate	34-65	V-set domain containing T cell activation inhibitor 1	Mus musculus	192-197
35410218-8	2022	Western blot analysis showed that Phorbol-12-Myristate-13-Acetate (TPA) increased B7-H4 expression in a concentration-dependent manner and that rottlerin abrogated the TPA-induced increase in B7-H4 expression.	Tetradecanoylphorbol Acetate	67-70	V-set domain containing T cell activation inhibitor 1	Mus musculus	82-87
35410218-8	2022	Western blot analysis showed that Phorbol-12-Myristate-13-Acetate (TPA) increased B7-H4 expression in a concentration-dependent manner and that rottlerin abrogated the TPA-induced increase in B7-H4 expression.	Tetradecanoylphorbol Acetate	168-171	V-set domain containing T cell activation inhibitor 1	Mus musculus	192-197
35193580-6	2022	CD98hc expression and proliferation rate of NE6 were up regulated by low dose H2O2 treatment and long term TPA treatment.	Tetradecanoylphorbol Acetate	107-110	solute carrier family 3 member 2	Homo sapiens	0-6
35166073-4	2022	METHODS: IL-17A production from 5 sorted peripheral blood cell populations, namely MAITs, gammadelta T-cells, CD4+T-cells, CD8+T-cells and neutrophils was evaluated pre- and post-stimulation with PMA, the calcium ionophore A23187 and beta1,3 glucan.	Tetradecanoylphorbol Acetate	196-199	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	234-241
35068054-4	2022	Furthermore, PPP2CB deletion did not affect T cell receptor (TCR)-induced T cell activation or cytokine-induced T cell responses; however, it specifically enhanced phorbol myristate acetate (PMA) plus ionomycin-induced T cell activation with increased cellular proliferation, elevated CD69 and CD25 expression, and enhanced cytokines production (IFN-gamma, IL-2 and TNF).	Tetradecanoylphorbol Acetate	164-189	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	Mus musculus	13-19
35068054-4	2022	Furthermore, PPP2CB deletion did not affect T cell receptor (TCR)-induced T cell activation or cytokine-induced T cell responses; however, it specifically enhanced phorbol myristate acetate (PMA) plus ionomycin-induced T cell activation with increased cellular proliferation, elevated CD69 and CD25 expression, and enhanced cytokines production (IFN-gamma, IL-2 and TNF).	Tetradecanoylphorbol Acetate	164-189	interleukin 2	Mus musculus	357-361
35068054-4	2022	Furthermore, PPP2CB deletion did not affect T cell receptor (TCR)-induced T cell activation or cytokine-induced T cell responses; however, it specifically enhanced phorbol myristate acetate (PMA) plus ionomycin-induced T cell activation with increased cellular proliferation, elevated CD69 and CD25 expression, and enhanced cytokines production (IFN-gamma, IL-2 and TNF).	Tetradecanoylphorbol Acetate	191-194	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	Mus musculus	13-19
2513320-3	1989	Among them, the HSB2 cell line turned out to be the only one secreting significant HILDA activity (200-400 units/ml) after activation with 50 nM phorbol myristate acetate.	Tetradecanoylphorbol Acetate	145-170	LIF interleukin 6 family cytokine	Homo sapiens	83-88
2513320-5	1989	One of them (2B3) was found to secrete 1,000-5,000 units/ml of HILDA after phorbol myristate acetate activation in the presence of 10% fetal calf serum and 200-500 units/ml in serum-free conditions.	Tetradecanoylphorbol Acetate	75-100	LIF interleukin 6 family cytokine	Homo sapiens	63-68
2555368-1	1989	Modulation of tissue factor, plasminogen activator inhibitors, and thrombomodulin by phorbol 12-myristate 13-acetate and tumor necrosis factor.	Tetradecanoylphorbol Acetate	85-116	coagulation factor III, tissue factor	Homo sapiens	14-27
2555368-1	1989	Modulation of tissue factor, plasminogen activator inhibitors, and thrombomodulin by phorbol 12-myristate 13-acetate and tumor necrosis factor.	Tetradecanoylphorbol Acetate	85-116	thrombomodulin	Homo sapiens	67-81
2637248-1	1989	Tumor promoting phorbol esters, 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol-12,13-dibutyrate (PDBu), significantly enhanced the growth of human gastric cancer cell line TMK-1, whilst activating protein kinase C. The time course of 125I-epidermal growth factor (EGF) binding to TMK-1 cells after TPA treatment showed a decrease in the number of EGF receptors on TMK-1 cells within 3 hr.	Tetradecanoylphorbol Acetate	32-68	epidermal growth factor	Homo sapiens	242-270
2637248-1	1989	Tumor promoting phorbol esters, 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol-12,13-dibutyrate (PDBu), significantly enhanced the growth of human gastric cancer cell line TMK-1, whilst activating protein kinase C. The time course of 125I-epidermal growth factor (EGF) binding to TMK-1 cells after TPA treatment showed a decrease in the number of EGF receptors on TMK-1 cells within 3 hr.	Tetradecanoylphorbol Acetate	32-68	epidermal growth factor	Homo sapiens	272-275
2637248-1	1989	Tumor promoting phorbol esters, 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol-12,13-dibutyrate (PDBu), significantly enhanced the growth of human gastric cancer cell line TMK-1, whilst activating protein kinase C. The time course of 125I-epidermal growth factor (EGF) binding to TMK-1 cells after TPA treatment showed a decrease in the number of EGF receptors on TMK-1 cells within 3 hr.	Tetradecanoylphorbol Acetate	32-68	epidermal growth factor	Homo sapiens	355-358
2637248-1	1989	Tumor promoting phorbol esters, 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol-12,13-dibutyrate (PDBu), significantly enhanced the growth of human gastric cancer cell line TMK-1, whilst activating protein kinase C. The time course of 125I-epidermal growth factor (EGF) binding to TMK-1 cells after TPA treatment showed a decrease in the number of EGF receptors on TMK-1 cells within 3 hr.	Tetradecanoylphorbol Acetate	70-73	epidermal growth factor	Homo sapiens	242-270
2637248-1	1989	Tumor promoting phorbol esters, 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol-12,13-dibutyrate (PDBu), significantly enhanced the growth of human gastric cancer cell line TMK-1, whilst activating protein kinase C. The time course of 125I-epidermal growth factor (EGF) binding to TMK-1 cells after TPA treatment showed a decrease in the number of EGF receptors on TMK-1 cells within 3 hr.	Tetradecanoylphorbol Acetate	70-73	epidermal growth factor	Homo sapiens	272-275
2637248-1	1989	Tumor promoting phorbol esters, 12-O-tetradecanoylphorbol-13-acetate (TPA) and phorbol-12,13-dibutyrate (PDBu), significantly enhanced the growth of human gastric cancer cell line TMK-1, whilst activating protein kinase C. The time course of 125I-epidermal growth factor (EGF) binding to TMK-1 cells after TPA treatment showed a decrease in the number of EGF receptors on TMK-1 cells within 3 hr.	Tetradecanoylphorbol Acetate	70-73	epidermal growth factor	Homo sapiens	355-358
2637248-2	1989	Autophosphorylation of EGF receptor decreased in accordance with the decrease of EGF binding by TPA treatment.	Tetradecanoylphorbol Acetate	96-99	epidermal growth factor	Homo sapiens	23-26
2637248-2	1989	Autophosphorylation of EGF receptor decreased in accordance with the decrease of EGF binding by TPA treatment.	Tetradecanoylphorbol Acetate	96-99	epidermal growth factor	Homo sapiens	81-84
2637248-3	1989	Scatchard plot analysis of TMK-1 cells after TPA treatment showed that high affinity EGF receptor disappeared at 3hr but the number of EGF receptors increased at 24 hr.	Tetradecanoylphorbol Acetate	45-48	epidermal growth factor	Homo sapiens	85-88
2533931-5	1989	Northern blot analyses demonstrated that TPA induced increased levels of fos, myc, phorbin, and ODC RNAs in control K16MV7 and K22MV7 cells, with maximum induction occurring at about 0.5, 1, 8, and 8 h, respectively.	Tetradecanoylphorbol Acetate	41-44	ornithine decarboxylase 1	Rattus norvegicus	96-99
2533931-6	1989	In K16PKC-4 and K22PKC-2 cells, TPA induction of phorbin and ODC RNAs was markedly enhanced, but this was not the case for myc and fos RNAs.	Tetradecanoylphorbol Acetate	32-35	ornithine decarboxylase 1	Rattus norvegicus	61-64
2555384-9	1989	Incorporation of [35S]methionine into immunoreactive IGFBP-1, as detected by sodium dodecyl sulfate-polyacrylamide electrophoresis and fluorography, was also increased by TPA.	Tetradecanoylphorbol Acetate	171-174	insulin like growth factor binding protein 1	Homo sapiens	53-60
2555384-10	1989	This suggests that TPA accelerated the synthesis of IGFBP-1.	Tetradecanoylphorbol Acetate	19-22	insulin like growth factor binding protein 1	Homo sapiens	52-59
2481153-7	1989	However, the secreted tPA was composed mostly of an inactive form of tPA.PAI-1 complex, and the PA activity was derived mostly from uPA.	Tetradecanoylphorbol Acetate	22-25	plasminogen activator, urokinase	Bos taurus	132-135
2601687-1	1989	12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	0-36	epidermal growth factor	Mus musculus	96-124
2601687-1	1989	12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	0-36	epidermal growth factor	Mus musculus	126-129
2601687-1	1989	12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	38-41	epidermal growth factor	Mus musculus	96-124
2601687-1	1989	12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	38-41	epidermal growth factor	Mus musculus	126-129
2601687-2	1989	TPA (30 nM)-caused ODC induction was almost completely blocked by 30 microM H-7 [1-(5-isoquinolinylsulfonyl)-2-methylpiperazine], a well known protein kinase C inhibitor, but the same concentration of H-7 failed to restore the 125I-EGF binding suppressed by TPA (10 nM).	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor	Mus musculus	232-235
2601687-3	1989	On the other hand, sphingosine, another protein kinase C inhibitor, blocked not only TPA-caused ODC induction but also TPA-caused suppression of 125I-EGF binding.	Tetradecanoylphorbol Acetate	119-122	epidermal growth factor	Mus musculus	150-153
2633049-1	1989	As judged by Western blot analysis, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBU) induce the rapid and dose-dependent appearance of slower mobility CD5 molecular forms from peripheral blood mononuclear cell (PBMC) and thymus cell lysates.	Tetradecanoylphorbol Acetate	36-67	CD5 molecule	Homo sapiens	176-179
2633049-1	1989	As judged by Western blot analysis, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBU) induce the rapid and dose-dependent appearance of slower mobility CD5 molecular forms from peripheral blood mononuclear cell (PBMC) and thymus cell lysates.	Tetradecanoylphorbol Acetate	69-72	CD5 molecule	Homo sapiens	176-179
2679916-8	1989	In addition, exposure of cells to 12-O-tetradecanoylphorbol 13-acetate did not alter stability of M-CSF mRNA but markedly prolonged the stability of GM-CSF mRNA.	Tetradecanoylphorbol Acetate	34-70	colony stimulating factor 2	Homo sapiens	149-155
2555220-0	1989	A type 2A protein phosphatase dephosphorylates the elongation factor 2 and is stimulated by the phorbol ester TPA in mouse epidermis in vivo.	Tetradecanoylphorbol Acetate	110-113	eukaryotic translation elongation factor 2	Mus musculus	51-70
2555220-1	1989	Mouse epidermal cytosol contains a protein phosphatase with Mr 38,000, which dephosphorylates the elongation factor 2 (EF-2) of protein biosynthesis and is stimulated after topical application of TPA to mouse skin [(1988) Biochem.	Tetradecanoylphorbol Acetate	196-199	eukaryotic translation elongation factor 2	Mus musculus	98-117
2555220-1	1989	Mouse epidermal cytosol contains a protein phosphatase with Mr 38,000, which dephosphorylates the elongation factor 2 (EF-2) of protein biosynthesis and is stimulated after topical application of TPA to mouse skin [(1988) Biochem.	Tetradecanoylphorbol Acetate	196-199	eukaryotic translation elongation factor 2	Mus musculus	119-123
2555220-10	1989	These data indicate that the TPA-stimulated EF-2 phosphatase in epidermal cytosol is a type 2A protein phosphatase.	Tetradecanoylphorbol Acetate	29-32	eukaryotic translation elongation factor 2	Mus musculus	44-48
2555224-6	1989	In membranes from TPA-treated platelets, the receptors were in the low-affinity state and no further decrease in affinity was induced by Gpp(NH)p. Our data suggest that activation of protein kinase C in platelets blocks the hormonal inhibition of adenylate cyclase by interfering with the receptor-Gi interaction.	Tetradecanoylphorbol Acetate	18-21	hydroxycarboxylic acid receptor 3	Homo sapiens	298-300
2516715-3	1989	All three interferons and TPA enhanced the expression of the Mr 180,000 carcinoembryonic antigen (CEA) and CEA-related TAA recognized by monoclonal antibody B1.1 in both T47D and MCF-7 human breast carcinoma cell lines.	Tetradecanoylphorbol Acetate	26-29	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	72-96
2516715-3	1989	All three interferons and TPA enhanced the expression of the Mr 180,000 carcinoembryonic antigen (CEA) and CEA-related TAA recognized by monoclonal antibody B1.1 in both T47D and MCF-7 human breast carcinoma cell lines.	Tetradecanoylphorbol Acetate	26-29	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	98-101
2516715-3	1989	All three interferons and TPA enhanced the expression of the Mr 180,000 carcinoembryonic antigen (CEA) and CEA-related TAA recognized by monoclonal antibody B1.1 in both T47D and MCF-7 human breast carcinoma cell lines.	Tetradecanoylphorbol Acetate	26-29	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	107-110
2516715-5	1989	In general, IFN-gamma was more effective than IFN-alpha, IFN-beta or TPA in augmenting the expression of TAA, CEA and BCA-225, and HLA-DR expression in T47D and MCF-7 cells.	Tetradecanoylphorbol Acetate	69-72	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	110-113
2574679-5	1989	Similarly to plastic-adsorbed antibodies, phorbol myristic acetate (PMA) or a combination of PMA and the calcium ionophore Ionomycin also induces secretion of growth factors without inducing proliferation, but in this case addition of IL 1 is ineffective in inducing AK-8 proliferation.	Tetradecanoylphorbol Acetate	68-71	adenylate kinase 8	Mus musculus	267-271
2613691-7	1989	Addition of phorbol 12-myristate 13-acetate (PMA) to the culture inhibited IL5-mediated differentiative responses.	Tetradecanoylphorbol Acetate	12-43	interleukin 5	Mus musculus	75-78
2613691-7	1989	Addition of phorbol 12-myristate 13-acetate (PMA) to the culture inhibited IL5-mediated differentiative responses.	Tetradecanoylphorbol Acetate	45-48	interleukin 5	Mus musculus	75-78
28305485-5	1989	The uPA mRNA is first detected in cephalic mesenchyme at E8.5 when tPA mRNA is already widely distributed in tissues derived from ectoderm and mesoderm; later, the uPA mRNA transcripts were found throughout most mesodermic tissues, (b) Each gene presents a different pattern of expression.	Tetradecanoylphorbol Acetate	67-70	plasminogen activator, urokinase	Mus musculus	4-7
2676015-5	1989	On stimulation of BMCs with phorbol myristate acetate (PMA) and phytohemagglutinin or PMA and the calcium ionophore ionomycin, approximately 5% expressed GM-CSF mRNA and approximately 1% IL-3 mRNA.	Tetradecanoylphorbol Acetate	28-53	colony stimulating factor 2	Homo sapiens	154-160
2670202-7	1989	In this paper, we show that exposing phorbol ester-sensitive (S) HL-60 cells to TPA caused the disappearance of the c-myc protein antigen (detected on Western blots) in 4 h, whereas TPA had no effect on the c-myc protein content of PET cells.	Tetradecanoylphorbol Acetate	80-83	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	116-121
2670202-7	1989	In this paper, we show that exposing phorbol ester-sensitive (S) HL-60 cells to TPA caused the disappearance of the c-myc protein antigen (detected on Western blots) in 4 h, whereas TPA had no effect on the c-myc protein content of PET cells.	Tetradecanoylphorbol Acetate	80-83	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	207-212
2670202-11	1989	TPA induced the down-regulation of c-myc mRNA in S cells to a greater extent than in PET cells.	Tetradecanoylphorbol Acetate	0-3	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	35-40
2509225-0	1989	Reduced induction of c-fos but not of c-myc expressions in a nontumorigenic revertant R1 of Ej-ras-transformed NIH/3T3 cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	138-174	FBJ osteosarcoma oncogene	Mus musculus	21-26
2509225-1	1989	It has been reported that both c-fos and c-myc mRNAs are induced in NIH/3T3 cells after 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	88-124	FBJ osteosarcoma oncogene	Mus musculus	31-36
2509225-1	1989	It has been reported that both c-fos and c-myc mRNAs are induced in NIH/3T3 cells after 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	126-129	FBJ osteosarcoma oncogene	Mus musculus	31-36
2509225-2	1989	We have studied the effect of TPA on the expression of c-fos and c-myc in EJ-ras-transformed NIH/3T3 and its nontumorigenic flat revertant R1 cells.	Tetradecanoylphorbol Acetate	30-33	FBJ osteosarcoma oncogene	Mus musculus	55-60
2509225-3	1989	Although TPA treatment induces c-myc mRNA, as in the case of NIH/3T3 cells, the induced level of c-fos mRNA is greatly reduced not only in slow-growing EJ-ras-transformed NIH/3T3 but also in quiescent R1 cells.	Tetradecanoylphorbol Acetate	9-12	FBJ osteosarcoma oncogene	Mus musculus	97-102
2509225-5	1989	These observations suggest that the pathway from TPA to c-fos gene is different from that to c-myc gene and that the former pathway is down-regulated in association not with the transformed phenotype, but with EJ-ras expression, and it is possible that this reduced induction of c-fos is not specific to TPA.	Tetradecanoylphorbol Acetate	49-52	FBJ osteosarcoma oncogene	Mus musculus	56-61
2509225-5	1989	These observations suggest that the pathway from TPA to c-fos gene is different from that to c-myc gene and that the former pathway is down-regulated in association not with the transformed phenotype, but with EJ-ras expression, and it is possible that this reduced induction of c-fos is not specific to TPA.	Tetradecanoylphorbol Acetate	49-52	FBJ osteosarcoma oncogene	Mus musculus	279-284
2509225-5	1989	These observations suggest that the pathway from TPA to c-fos gene is different from that to c-myc gene and that the former pathway is down-regulated in association not with the transformed phenotype, but with EJ-ras expression, and it is possible that this reduced induction of c-fos is not specific to TPA.	Tetradecanoylphorbol Acetate	304-307	FBJ osteosarcoma oncogene	Mus musculus	56-61
2674282-4	1989	Our results demonstrate that the phorbol diester, 12-O-tetradecanoylphorbol 13-acetate, can stimulate GM-CSF transcription via sequences located within 53 bp upstream of the GM-CSF cap site.	Tetradecanoylphorbol Acetate	50-86	colony stimulating factor 2	Homo sapiens	102-108
2674282-4	1989	Our results demonstrate that the phorbol diester, 12-O-tetradecanoylphorbol 13-acetate, can stimulate GM-CSF transcription via sequences located within 53 bp upstream of the GM-CSF cap site.	Tetradecanoylphorbol Acetate	50-86	colony stimulating factor 2	Homo sapiens	174-180
2504306-5	1989	PMA also induces secretion of the two inhibitors of plasminogen activator: plasminogen activator inhibitor 1 (PAI-1) and plasminogen activator inhibitor 2 (PAI-2).	Tetradecanoylphorbol Acetate	0-3	serpin family E member 1	Homo sapiens	75-108
2504306-5	1989	PMA also induces secretion of the two inhibitors of plasminogen activator: plasminogen activator inhibitor 1 (PAI-1) and plasminogen activator inhibitor 2 (PAI-2).	Tetradecanoylphorbol Acetate	0-3	serpin family E member 1	Homo sapiens	110-115
2504306-5	1989	PMA also induces secretion of the two inhibitors of plasminogen activator: plasminogen activator inhibitor 1 (PAI-1) and plasminogen activator inhibitor 2 (PAI-2).	Tetradecanoylphorbol Acetate	0-3	serpin family B member 2	Homo sapiens	121-154
2504306-5	1989	PMA also induces secretion of the two inhibitors of plasminogen activator: plasminogen activator inhibitor 1 (PAI-1) and plasminogen activator inhibitor 2 (PAI-2).	Tetradecanoylphorbol Acetate	0-3	serpin family B member 2	Homo sapiens	156-161
2547873-2	1989	This study examined the ability of four neutral proteases: cathepsin G, elastase, chymotrypsin, and trypsin, to modify PMN superoxide response to FMLP, PMA, and arachidonate.	Tetradecanoylphorbol Acetate	152-155	cathepsin G	Homo sapiens	59-80
2588913-5	1989	However, in the case of 7402 cells, while the number of receptors, like 7721 cells, remained unchanged, the affinity of EGF receptors displayed a time dependent modulation after PMA treatment.	Tetradecanoylphorbol Acetate	178-181	epidermal growth factor	Homo sapiens	120-123
2483473-5	1989	TSH stimulates cAMP production in thyroid cells, calf serum acts through ill-defined pathways to stimulate growth, and TPA is known to activate protein kinase C. Bovine calf serum and TSH acted synergistically to induce ornithine decarboxylase activity.	Tetradecanoylphorbol Acetate	119-122	ornithine decarboxylase 1	Rattus norvegicus	220-243
2483473-10	1989	Difluoromethylornithine, a specific inhibitor of ornithine decarboxylase, inhibited growth induced by both TPA and TSH in putrescine-free medium.	Tetradecanoylphorbol Acetate	107-110	ornithine decarboxylase 1	Rattus norvegicus	49-72
2760060-6	1989	The BCP stimulation of c-fos and c-myc messages was inhibited 60 and 90%, respectively, in TPA-pretreated, protein kinase C-down-regulated cells.	Tetradecanoylphorbol Acetate	91-94	FBJ osteosarcoma oncogene	Mus musculus	23-28
2568381-6	1989	Pretreatment of rabbits with anti-CD18 and anti-ICAM-1 but not anti-CD11a mAb inhibited by greater than 60% neutrophil migration into PMA-induced inflamed rabbit lungs.	Tetradecanoylphorbol Acetate	134-137	ICAM-1	Oryctolagus cuniculus	48-54
2677677-5	1989	When GM-CSF-deprived 32D clone 3 cells were exposed to GM-CSF or to TPA, four TIS mRNAs (TIS7, TIS8, TIS10, and TIS11) were rapidly and transiently induced.	Tetradecanoylphorbol Acetate	68-71	interferon-related developmental regulator 1	Mus musculus	89-93
2677677-5	1989	When GM-CSF-deprived 32D clone 3 cells were exposed to GM-CSF or to TPA, four TIS mRNAs (TIS7, TIS8, TIS10, and TIS11) were rapidly and transiently induced.	Tetradecanoylphorbol Acetate	68-71	early growth response 1	Mus musculus	95-99
2677677-7	1989	Both GM-CSF and TPA also elicited rapid, transient expression of TIS8 and TIS11 mRNA in postmitotic human neutrophils.	Tetradecanoylphorbol Acetate	16-19	early growth response 1	Homo sapiens	65-69
2548188-0	1989	Phorbol 12-myristate 13-acetate inhibits binding of leukotriene B4 and platelet-activating factor and the responses they induce in neutrophils: site of action.	Tetradecanoylphorbol Acetate	0-31	PCNA clamp associated factor	Homo sapiens	71-97
2548188-3	1989	Incubation of human neutrophils with the tumor copromoter phorbol 12-myristate 13-acetate (PMA) for 3 min prior to the addition of the stimulus inhibits all these responses produced by PAF.	Tetradecanoylphorbol Acetate	58-89	PCNA clamp associated factor	Homo sapiens	185-188
2548188-3	1989	Incubation of human neutrophils with the tumor copromoter phorbol 12-myristate 13-acetate (PMA) for 3 min prior to the addition of the stimulus inhibits all these responses produced by PAF.	Tetradecanoylphorbol Acetate	91-94	PCNA clamp associated factor	Homo sapiens	185-188
2548188-7	1989	The binding of either PAF or leukotriene B4 to intact cells is inhibited by PMA.	Tetradecanoylphorbol Acetate	76-79	PCNA clamp associated factor	Homo sapiens	22-25
2551669-2	1989	Here we demonstrate that the normal c-myc allele can be induced in BL cells by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	79-115	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	36-41
2551669-2	1989	Here we demonstrate that the normal c-myc allele can be induced in BL cells by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	117-120	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	36-41
2551669-3	1989	TPA did activate the normal c-myc alleles in Raji(P207), BL36, P3HR1, Jijoye and LY91 cells, but not in Raji(DE88), BL41, BL67, LY47 and KK124 cells.	Tetradecanoylphorbol Acetate	0-3	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	28-33
2551669-4	1989	C-myc RNA derived from the normal allele appeared 6 h after treatment with TPA and showed the characteristic preferential usage of the second promoter.	Tetradecanoylphorbol Acetate	75-78	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
2551669-8	1989	Expression of the translocated c-myc alleles was also affected by TPA; however, only if cycloheximide was simultaneously present.	Tetradecanoylphorbol Acetate	66-69	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	31-36
2551669-9	1989	TPA plus cycloheximide induced a rapid decrease of c-myc RNA derived from the translocated allele within 6 h, whereas cycloheximide alone led to abolition of c-myc RNA after 16-24 h. This rapid decline of c-myc RNA was observed in Raji and BL41 cells, but not in three cell lines with variant t(2;8) and t(8;22) translocations.	Tetradecanoylphorbol Acetate	0-3	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	51-56
2551669-9	1989	TPA plus cycloheximide induced a rapid decrease of c-myc RNA derived from the translocated allele within 6 h, whereas cycloheximide alone led to abolition of c-myc RNA after 16-24 h. This rapid decline of c-myc RNA was observed in Raji and BL41 cells, but not in three cell lines with variant t(2;8) and t(8;22) translocations.	Tetradecanoylphorbol Acetate	0-3	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	158-163
2551669-9	1989	TPA plus cycloheximide induced a rapid decrease of c-myc RNA derived from the translocated allele within 6 h, whereas cycloheximide alone led to abolition of c-myc RNA after 16-24 h. This rapid decline of c-myc RNA was observed in Raji and BL41 cells, but not in three cell lines with variant t(2;8) and t(8;22) translocations.	Tetradecanoylphorbol Acetate	0-3	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	158-163
2500119-0	1989	Indomethacin shifts the peak of c-fos, egr-1, and c-myc gene expression in confluent fibroblasts induced by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	108-133	FBJ osteosarcoma oncogene	Mus musculus	32-37
2500119-0	1989	Indomethacin shifts the peak of c-fos, egr-1, and c-myc gene expression in confluent fibroblasts induced by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	108-133	early growth response 1	Mus musculus	39-44
2552771-0	1989	Chondrocyte activation by interleukin-1: synergism with fibroblast growth factor and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	85-110	interleukin 1 alpha	Homo sapiens	26-39
2472158-2	1989	The ability to mount an oxidative burst (OB) in response to medium, zymosan and phorbol myristate acetate (PMA) was assessed in human blood monocytes cultured for 1 day (MO) and monocyte-derived macrophages cultured for 10 days (MDM).	Tetradecanoylphorbol Acetate	107-110	secreted LY6/PLAUR domain containing 1	Homo sapiens	229-232
2474754-1	1989	The product of the c-src proto-oncogene, pp60c-src, is phosphorylated at Ser-17 by cyclic AMP-dependent protein kinase A and at Ser-12 by calcium-phospholipid-dependent protein kinase C (when stimulated by 12-O-tetradecanoyl phorbol acetate).	Tetradecanoylphorbol Acetate	206-240	Rous sarcoma oncogene	Mus musculus	21-24
2474754-1	1989	The product of the c-src proto-oncogene, pp60c-src, is phosphorylated at Ser-17 by cyclic AMP-dependent protein kinase A and at Ser-12 by calcium-phospholipid-dependent protein kinase C (when stimulated by 12-O-tetradecanoyl phorbol acetate).	Tetradecanoylphorbol Acetate	206-240	Rous sarcoma oncogene	Mus musculus	41-50
2765502-2	1989	Induction of LPL in THP-1 cells appears to be mediated by PKC since it was affected by both phorbol 12-myristate 13-acetate (PMA) and a diacylglycerol analogue.	Tetradecanoylphorbol Acetate	92-123	lipoprotein lipase	Homo sapiens	13-16
2765502-2	1989	Induction of LPL in THP-1 cells appears to be mediated by PKC since it was affected by both phorbol 12-myristate 13-acetate (PMA) and a diacylglycerol analogue.	Tetradecanoylphorbol Acetate	125-128	lipoprotein lipase	Homo sapiens	13-16
2706740-4	1989	The maximal velocities for TPA-stimulated epidermal PKC activity in CD-1, DBA/2 and C57BL/6 were 0.28, 0.29 and 0.27 nmol PO4-histone/mg 10(5)g protein/min, respectively.	Tetradecanoylphorbol Acetate	27-30	CD1 antigen complex	Mus musculus	68-72
2706740-5	1989	TPA-stimulated epidermal PKC from CD-1, DBA/2 and C57BL/6 had similar theoretical Vmax values and the apparent concentrations of TPA yielding half-maximal stimulation of PKC were also similar.	Tetradecanoylphorbol Acetate	0-3	CD1 antigen complex	Mus musculus	34-38
2706740-10	1989	After topical treatment with TPA, C57BL/6 demonstrated an unexpected 2- and 4-fold increase in ODC activity over CD-1 and DBA/2 mice.	Tetradecanoylphorbol Acetate	29-32	CD1 antigen complex	Mus musculus	113-117
2472277-4	1989	More recently CD5 has been found to be present on human B lymphocytes following in vitro activation with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	105-130	CD5 molecule	Homo sapiens	14-17
2666557-5	1989	Chronic exposure to 12-0-tetradecanoylphorbol-13-acetate (TPA), which inhibits insulin release in the human fetal pancreas, caused an 85% drop in IGF-II production, which was reversed when TPA was removed.	Tetradecanoylphorbol Acetate	58-61	insulin like growth factor 2	Homo sapiens	146-152
2666557-5	1989	Chronic exposure to 12-0-tetradecanoylphorbol-13-acetate (TPA), which inhibits insulin release in the human fetal pancreas, caused an 85% drop in IGF-II production, which was reversed when TPA was removed.	Tetradecanoylphorbol Acetate	189-192	insulin like growth factor 2	Homo sapiens	146-152
2495278-1	1989	In this study we report that pretreatment of human amniotic (WISH) cells with interferon gamma (IFN-gamma) in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in the down-modulation of epidermal growth factor (EGF) receptors with respect to both receptor number and affinity.	Tetradecanoylphorbol Acetate	126-162	epidermal growth factor	Homo sapiens	204-227
2495278-1	1989	In this study we report that pretreatment of human amniotic (WISH) cells with interferon gamma (IFN-gamma) in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in the down-modulation of epidermal growth factor (EGF) receptors with respect to both receptor number and affinity.	Tetradecanoylphorbol Acetate	126-162	epidermal growth factor	Homo sapiens	229-232
2495278-1	1989	In this study we report that pretreatment of human amniotic (WISH) cells with interferon gamma (IFN-gamma) in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in the down-modulation of epidermal growth factor (EGF) receptors with respect to both receptor number and affinity.	Tetradecanoylphorbol Acetate	164-167	epidermal growth factor	Homo sapiens	204-227
2495278-1	1989	In this study we report that pretreatment of human amniotic (WISH) cells with interferon gamma (IFN-gamma) in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in the down-modulation of epidermal growth factor (EGF) receptors with respect to both receptor number and affinity.	Tetradecanoylphorbol Acetate	164-167	epidermal growth factor	Homo sapiens	229-232
2495278-3	1989	Pretreatment with IFN-gamma for 24 h enhanced the TPA-induced inhibition of EGF binding whereas IFN-gamma alone had no effect on binding.	Tetradecanoylphorbol Acetate	50-53	epidermal growth factor	Homo sapiens	76-79
2784463-6	1989	In addition, we show that the PMA-induced modification of p56lck proceeds via a mechanism distinct from conventional protein kinase C activation.	Tetradecanoylphorbol Acetate	30-33	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	58-64
2522906-7	1989	Although both H-2-positive and -negative subclones expressed CD3 antigen and produced IL-2 after activation with the phorbol ester TPA, only the H-2-positive cell clones produced IL-2 and expressed IL-2 receptor after anti-CD3 antibody induction.	Tetradecanoylphorbol Acetate	131-134	interleukin 2	Mus musculus	86-90
2468125-4	1989	Differentiated BC3H-1 monocytes showed an approximate twofold elevation in the [32P] content of pp60c-src following stimulation with insulin or TPA for 20 min, with no detectable change in the level of immunoprecipitable c-src protein.	Tetradecanoylphorbol Acetate	144-147	Rous sarcoma oncogene	Mus musculus	96-105
2468125-8	1989	In cells exposed to high concentrations of TPA for 16 h to deplete PK-C activity, insulin, but not TPA, stimulated phosphorylation of pp60c-src.	Tetradecanoylphorbol Acetate	43-46	Rous sarcoma oncogene	Mus musculus	134-143
2919678-5	1989	In contrast, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate and the synthetic diacylglycerol 1-oleoyl-2-acetyl-sn-glycerol inhibited both aminopyrine uptake and membrane inositol phospholipid turnover in parietal cells induced by carbachol and gastrin.	Tetradecanoylphorbol Acetate	31-67	gastrin	Homo sapiens	252-259
2522880-4	1989	In the presence of the tumor promoter phorbol 12-myristate 13-acetate IL 1 augments IL 2 secretion and IL 2R expression of EL4 5D3 but not of EL4 D6/76 cells.	Tetradecanoylphorbol Acetate	38-69	interleukin 2	Mus musculus	84-88
2537321-3	1989	Phorbol myristate acetate (PMA), an inducer of U937 cell differentiation to macrophage-like cells, elicits a time- and concentration-dependent increase in the number of uPAR molecules as shown by binding, cross-linking, and immunoprecipitation studies.	Tetradecanoylphorbol Acetate	0-25	plasminogen activator, urokinase receptor	Homo sapiens	169-173
2537321-3	1989	Phorbol myristate acetate (PMA), an inducer of U937 cell differentiation to macrophage-like cells, elicits a time- and concentration-dependent increase in the number of uPAR molecules as shown by binding, cross-linking, and immunoprecipitation studies.	Tetradecanoylphorbol Acetate	27-30	plasminogen activator, urokinase receptor	Homo sapiens	169-173
2537325-4	1989	PT inhibition of IL-3-stimulated proliferation could be overcome by using the Ca++ ionophore A23187 in conjunction with TPA.	Tetradecanoylphorbol Acetate	120-123	interleukin 3	Homo sapiens	17-21
2465548-8	1989	Although constitutive levels of IL-1 biological activity and protein are significant in these cultures, IL-1 levels increase when either PMA or retinoic acid alone are added to cultures.	Tetradecanoylphorbol Acetate	137-140	interleukin 1 alpha	Homo sapiens	104-108
2465548-9	1989	IL-1 does not increase when PMA and retinoic acid are added simultaneously to cultures; nor is it induced when extracellular Ca2+ concentrations are raised to 2 mM.	Tetradecanoylphorbol Acetate	28-31	interleukin 1 alpha	Homo sapiens	0-4
2642389-0	1989	Stimulation of a calcium-dependent actin nucleation activity by phorbol 12-myristate 13-acetate in rabbit macrophage cytoskeletons.	Tetradecanoylphorbol Acetate	64-95	actin	Oryctolagus cuniculus	35-40
2642389-3	1989	Cytoskeletons prepared from macrophages treated with phorbol 12-myristate 13-acetate for 20-30 s before permeabilization, markedly stimulated (300% of control) the rate of actin assembly, and this increment was completely cytochalasin-sensitive, indicating that exposure to phorbol leads to formation of free barbed ends.	Tetradecanoylphorbol Acetate	53-84	actin	Oryctolagus cuniculus	172-177
2523864-1	1989	Recombinant IL-2 (rIL-2) and IL-4 (rIL-4) promote proliferation of human CD4+ T cells activated in the presence of PHA, TPA or OKT-3 monoclonal antibody (MAb), whereas the production of interferon-gamma (IFN) can be induced only by rIL-2.	Tetradecanoylphorbol Acetate	120-123	interleukin 2	Rattus norvegicus	18-23
2783435-6	1989	PMA could induce CD4 and CD8 phosphorylation in both CD3L and CD3H fractions.	Tetradecanoylphorbol Acetate	0-3	CD247 molecule	Homo sapiens	62-66
2912135-4	1989	The protein kinase C inhibitor sphingosine inhibited aggregation and p47 phosphorylation caused by PMA or DAG alone or with thrombin, but the [Ca2+]i rise in response to the first agonist was not affected.	Tetradecanoylphorbol Acetate	99-102	inhibitor of growth family member 1	Homo sapiens	69-72
2462935-7	1989	In vitro studies of dual-fluorochrome-sorted, TPA-stimulated splenic B cells demonstrated significantly greater tritiated thymidine incorporation and Ig secretion by the CD20+ CD5- cells than by the CD20+ CD5+ subset.	Tetradecanoylphorbol Acetate	46-49	CD5 molecule	Homo sapiens	176-179
2462935-7	1989	In vitro studies of dual-fluorochrome-sorted, TPA-stimulated splenic B cells demonstrated significantly greater tritiated thymidine incorporation and Ig secretion by the CD20+ CD5- cells than by the CD20+ CD5+ subset.	Tetradecanoylphorbol Acetate	46-49	CD5 molecule	Homo sapiens	205-208
2462935-8	1989	These phenotypic and functional studies are consistent with the notion that TPA-induced CD5+ B cells are a subset of in vitro activated B lymphocytes.	Tetradecanoylphorbol Acetate	76-79	CD5 molecule	Homo sapiens	88-91
2621323-1	1989	The ability of EL-4 thymoma cells to produce interleukin-2 (IL-2) following exposure to phorbol-12-myristate 13-acetate (PMA) and Concanavalin A (Con A) has been studied in vitro using medium containing either 10% or 1% fetal calf serum (FCS).	Tetradecanoylphorbol Acetate	88-119	interleukin 2	Mus musculus	45-58
2621323-1	1989	The ability of EL-4 thymoma cells to produce interleukin-2 (IL-2) following exposure to phorbol-12-myristate 13-acetate (PMA) and Concanavalin A (Con A) has been studied in vitro using medium containing either 10% or 1% fetal calf serum (FCS).	Tetradecanoylphorbol Acetate	88-119	interleukin 2	Mus musculus	60-64
2621323-1	1989	The ability of EL-4 thymoma cells to produce interleukin-2 (IL-2) following exposure to phorbol-12-myristate 13-acetate (PMA) and Concanavalin A (Con A) has been studied in vitro using medium containing either 10% or 1% fetal calf serum (FCS).	Tetradecanoylphorbol Acetate	121-124	interleukin 2	Mus musculus	45-58
2621323-1	1989	The ability of EL-4 thymoma cells to produce interleukin-2 (IL-2) following exposure to phorbol-12-myristate 13-acetate (PMA) and Concanavalin A (Con A) has been studied in vitro using medium containing either 10% or 1% fetal calf serum (FCS).	Tetradecanoylphorbol Acetate	121-124	interleukin 2	Mus musculus	60-64
2659507-3	1989	The BM B cells required two signals for GM-CSF production: LPS and a tumor promoting phorbol ester (TPA).	Tetradecanoylphorbol Acetate	100-103	colony stimulating factor 2	Homo sapiens	40-46
3192624-11	1988	These results suggest that PAF enhances PMA-induced particulate PKC activity by a calcium-dependent mechanism.	Tetradecanoylphorbol Acetate	40-43	PCNA clamp associated factor	Homo sapiens	27-30
3192624-12	1988	The enhancing effect of PAF may be directly involved in the mechanism whereby the phospholipid "primes" neutrophils for augmented oxidative responses to PMA.	Tetradecanoylphorbol Acetate	153-156	PCNA clamp associated factor	Homo sapiens	24-27
3264402-7	1988	Similar to its effect on wild-type receptors, phorbol 12-myristate 13-acetate abolished the mutant-receptor high-affinity binding sites for EGF.	Tetradecanoylphorbol Acetate	46-77	epidermal growth factor	Mus musculus	140-143
2460462-2	1988	Phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), partially mimics the stimulatory effect of IL-6 but reduces that effect of IL-1.	Tetradecanoylphorbol Acetate	15-51	interleukin 1 alpha	Homo sapiens	134-138
2460462-2	1988	Phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), partially mimics the stimulatory effect of IL-6 but reduces that effect of IL-1.	Tetradecanoylphorbol Acetate	53-56	interleukin 1 alpha	Homo sapiens	134-138
2460462-4	1988	These regulatory properties of TPA are also manifested in HepG2 cells transiently transfected with an indicator gene construct carrying the IL-1/IL-6 regulatory enhancer element of the rat alpha 1-acid glycoprotein gene.	Tetradecanoylphorbol Acetate	31-34	interleukin 1 alpha	Homo sapiens	140-144
2460462-5	1988	IL-6 and IL-1 act independently of TPA-inducible kinase C, and of changes in intracellular Ca2+ concentrations.	Tetradecanoylphorbol Acetate	35-38	interleukin 1 alpha	Homo sapiens	9-13
3056746-0	1988	Phorbol ester-responsive H-ras1 gene promoter contains multiple TPA-inducible/AP-1-binding consensus sequence elements.	Tetradecanoylphorbol Acetate	64-67	HRas proto-oncogene, GTPase	Homo sapiens	25-31
3056746-6	1988	We have noted four motifs in the H-ras1 promoter region which resemble TPA-inducible and AP-1-binding consensus sequences.	Tetradecanoylphorbol Acetate	71-74	HRas proto-oncogene, GTPase	Homo sapiens	33-39
2847729-6	1988	PAF was however distinguished by its potent capacity to stimulate O2- and H2O2 production even at late stages of macrophage maturation (18 days), at which time both PMA and zymosan lacked significant effect.	Tetradecanoylphorbol Acetate	165-168	PCNA clamp associated factor	Homo sapiens	0-3
3068231-9	1988	We investigated the effect of 8-Br-cAMP on PMA-induced c-fos and c-myc mRNA levels.	Tetradecanoylphorbol Acetate	43-46	FBJ osteosarcoma oncogene	Mus musculus	55-60
3262641-7	1988	This was not due solely to a property of the 145-2C11 antibody, because both TPA and the F23.1 anti-TCR mAb also provoked a faster modulation of the TCR in lpr DN LNC.	Tetradecanoylphorbol Acetate	77-80	T cell receptor alpha variable 6-3	Mus musculus	149-152
3053165-4	1988	These two pathways, which can be activated by phorbol myristate acetate (PMA) and ionomycin respectively, appear to play complementary roles in the transcriptional induction of c-myc gene expression by the antigen receptor complex.	Tetradecanoylphorbol Acetate	46-71	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	177-182
3053165-4	1988	These two pathways, which can be activated by phorbol myristate acetate (PMA) and ionomycin respectively, appear to play complementary roles in the transcriptional induction of c-myc gene expression by the antigen receptor complex.	Tetradecanoylphorbol Acetate	73-76	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	177-182
3261760-3	1988	Subsequent to PMA-induced modulation of the TCR/CD3 complex, increases in the mRNA levels of both the TCR-alpha and -beta genes were observed reaching a maximum 12 h after stimulation.	Tetradecanoylphorbol Acetate	14-17	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	44-47
3261760-3	1988	Subsequent to PMA-induced modulation of the TCR/CD3 complex, increases in the mRNA levels of both the TCR-alpha and -beta genes were observed reaching a maximum 12 h after stimulation.	Tetradecanoylphorbol Acetate	14-17	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	102-105
3139993-8	1988	Like GnRH, the protein kinase C activator phorbol myristate acetate also induced tPA mRNA in granulosa cells.	Tetradecanoylphorbol Acetate	42-67	gonadotropin releasing hormone 1	Rattus norvegicus	5-9
3139993-8	1988	Like GnRH, the protein kinase C activator phorbol myristate acetate also induced tPA mRNA in granulosa cells.	Tetradecanoylphorbol Acetate	42-67	plasminogen activator, tissue type	Rattus norvegicus	81-84
3265471-5	1988	Phorbol myristate acetate stimulation of resting T cells resulted in a 20-fold increase in steady-state 4F2HC mRNA levels which was mediated by removal of this block to transcription elongation.	Tetradecanoylphorbol Acetate	0-25	solute carrier family 3 member 2	Homo sapiens	104-109
3265471-6	1988	The phorbol myristate acetate-induced increase in 4F2HC gene expression is distinct from previously described AP-1-mediated, phorbol ester-induced gene expression in that it requires new protein synthesis.	Tetradecanoylphorbol Acetate	4-29	solute carrier family 3 member 2	Homo sapiens	50-55
3258574-4	1988	TPA to a variable degree also potentiates IL-2-stimulated growth of Nb2 cells when cultured in medium containing serum but has no effect on cells grown in serum-free medium.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Rattus norvegicus	42-46
3122755-5	1988	When IL1 was added together with human recombinant interferon-gamma (IFN-gamma), the resulting Fru-2,6-P2 level was synergistically increased, whilst the combination of IFN-gamma and TPA produced only an additive increase.	Tetradecanoylphorbol Acetate	183-186	interleukin 1 alpha	Homo sapiens	5-8
3257239-2	1988	It was found that these thymocytes proliferated extensively when cultured in the presence of IL-4 + phorbol myristate acetate without apparent differentiation to Lyt-2+ or L3T4+ cells.	Tetradecanoylphorbol Acetate	100-125	interleukin 4	Mus musculus	93-97
2838694-4	1988	Glucocorticoids having also been described as PLA2-inhibitors, their inhibitory effect on TPA-induced secretions could thus be related to their anti-PLA2 activity.	Tetradecanoylphorbol Acetate	90-93	phospholipase A2 group IB	Rattus norvegicus	46-50
2838694-4	1988	Glucocorticoids having also been described as PLA2-inhibitors, their inhibitory effect on TPA-induced secretions could thus be related to their anti-PLA2 activity.	Tetradecanoylphorbol Acetate	90-93	phospholipase A2 group IB	Rattus norvegicus	149-153
2838694-6	1988	Since in our model, EGF-induced PGE2 secretion is also inhibited by dexamethasone, these results suggest that a lipocortin-like protein could be present in pituitary cells and involved in the effect of TPA and EGF on PGE2, and, at least partly, on ACTH release.	Tetradecanoylphorbol Acetate	202-205	epidermal growth factor	Rattus norvegicus	20-23
3127645-4	1988	The tumor promoter tetradecanoyl phorbol acetate (TPA) was found to selectively induce the transcription of c-myc without observable effect on the transcription of the other oncogenes studied, and without inducing cell division.	Tetradecanoylphorbol Acetate	19-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	108-113
3127645-4	1988	The tumor promoter tetradecanoyl phorbol acetate (TPA) was found to selectively induce the transcription of c-myc without observable effect on the transcription of the other oncogenes studied, and without inducing cell division.	Tetradecanoylphorbol Acetate	50-53	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	108-113
3076452-5	1988	A tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) also augmented anchorage-independent growth of ras-transformed cells and induced morphological changes in monolayer cultures without altering the expression of the ras gene or phosphorylation of the p21ras protein.	Tetradecanoylphorbol Acetate	56-59	HRas proto-oncogene, GTPase	Rattus norvegicus	260-266
3124260-3	1988	The presence of a submitogenic concentration of the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) enormously enhanced the mitogenic activity of Datura lectin.	Tetradecanoylphorbol Acetate	66-103	LTL	Solanum lycopersicum	163-169
3124260-3	1988	The presence of a submitogenic concentration of the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) enormously enhanced the mitogenic activity of Datura lectin.	Tetradecanoylphorbol Acetate	105-108	LTL	Solanum lycopersicum	163-169
3500949-8	1987	Treatment of hepatocytes for 30-180 s with 1 micrograms/ml phorbol 12-myristate 13-acetate prior to the addition of EGF blocked the EGF-stimulated production of Ins(1,4,5)P3 and the increase in [Ca2+]i.	Tetradecanoylphorbol Acetate	59-90	epidermal growth factor	Rattus norvegicus	132-135
2824456-13	1987	Reversal of the inhibition of PAF and LTB4 accumulation occurred in parallel, was concentration-dependent, and was complete by approximately 3 x 10(-8) M PMA.	Tetradecanoylphorbol Acetate	154-157	PCNA clamp associated factor	Homo sapiens	30-33
3499220-4	1987	The action of EGF was antagonized by 12-O-tetradecanoylphorbol-13-acetate, which did not inhibit dexamethasone binding significantly, and by concanavalin A.	Tetradecanoylphorbol Acetate	37-73	epidermal growth factor	Homo sapiens	14-17
3499220-7	1987	The effect of EGF on dexamethasone-inhibited cell growth also was antagonized by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	81-117	epidermal growth factor	Homo sapiens	14-17
3501397-3	1987	The results showed that strong first stage and second stage tumor promoters such as TPA, PDBu, PRA, MEZ and APL are also strong stimulators of IL 1 and H2O2 generation, whereas weak tumor promoters exhibited a low, if any, effect at all.	Tetradecanoylphorbol Acetate	84-87	interleukin 1 alpha	Homo sapiens	143-156
3117882-1	1987	A B cell lymphoma A20.2J and splenic B cells produced an active material to support the proliferation of an interleukin 2 (IL-2)-dependent T cell line, CTLL-2, by stimulation with both calcium ionophore A23187 and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	214-239	interleukin 2	Mus musculus	108-121
3117882-1	1987	A B cell lymphoma A20.2J and splenic B cells produced an active material to support the proliferation of an interleukin 2 (IL-2)-dependent T cell line, CTLL-2, by stimulation with both calcium ionophore A23187 and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	214-239	interleukin 2	Mus musculus	123-127
3117882-1	1987	A B cell lymphoma A20.2J and splenic B cells produced an active material to support the proliferation of an interleukin 2 (IL-2)-dependent T cell line, CTLL-2, by stimulation with both calcium ionophore A23187 and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	241-244	interleukin 2	Mus musculus	108-121
3117882-1	1987	A B cell lymphoma A20.2J and splenic B cells produced an active material to support the proliferation of an interleukin 2 (IL-2)-dependent T cell line, CTLL-2, by stimulation with both calcium ionophore A23187 and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	241-244	interleukin 2	Mus musculus	123-127
3119352-7	1987	We found that calcium ionophore, PMA and OAG stimulation enhanced the expression of c-fos mRNA, but IFN-gamma treatment did not.	Tetradecanoylphorbol Acetate	33-36	FBJ osteosarcoma oncogene	Mus musculus	84-89
2821315-6	1987	The TPA-induced as well as the RA- and cAMP-induced decreases in the RNAs hybridizable to pFT27 were regulated at the transcriptional level, whereas similar decreases in the RNAs hybridizable to pFT43 and pFT60 were regulated at the post-transcriptional level.	Tetradecanoylphorbol Acetate	4-7	transmembrane protein 165	Mus musculus	90-95
3632701-0	1987	Transient induction of ornithine decarboxylase mRNA in rat hepatoma cells treated with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	87-123	ornithine decarboxylase 1	Rattus norvegicus	23-46
3632701-1	1987	The contribution of changes in mRNA levels to the induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat H35 hepatoma cells was analyzed by Northern blot and quantitative dot blot hybridization.	Tetradecanoylphorbol Acetate	96-132	ornithine decarboxylase 1	Rattus norvegicus	63-86
3632701-1	1987	The contribution of changes in mRNA levels to the induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat H35 hepatoma cells was analyzed by Northern blot and quantitative dot blot hybridization.	Tetradecanoylphorbol Acetate	96-132	ornithine decarboxylase 1	Rattus norvegicus	88-91
3632701-1	1987	The contribution of changes in mRNA levels to the induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat H35 hepatoma cells was analyzed by Northern blot and quantitative dot blot hybridization.	Tetradecanoylphorbol Acetate	134-137	ornithine decarboxylase 1	Rattus norvegicus	63-86
3632701-1	1987	The contribution of changes in mRNA levels to the induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat H35 hepatoma cells was analyzed by Northern blot and quantitative dot blot hybridization.	Tetradecanoylphorbol Acetate	134-137	ornithine decarboxylase 1	Rattus norvegicus	88-91
3632701-2	1987	ODC mRNA accumulated rapidly in TPA-treated cultures.	Tetradecanoylphorbol Acetate	32-35	ornithine decarboxylase 1	Rattus norvegicus	0-3
3632701-4	1987	The TPA dose-response for ODC message accumulation was half-maximal at approximately 0.18 microM TPA.	Tetradecanoylphorbol Acetate	4-7	ornithine decarboxylase 1	Rattus norvegicus	26-29
3632701-4	1987	The TPA dose-response for ODC message accumulation was half-maximal at approximately 0.18 microM TPA.	Tetradecanoylphorbol Acetate	97-100	ornithine decarboxylase 1	Rattus norvegicus	26-29
3632701-5	1987	The increase was completely blocked by actinomycin D, suggesting that TPA stimulates the transcription of ODC genes.	Tetradecanoylphorbol Acetate	70-73	ornithine decarboxylase 1	Rattus norvegicus	106-109
2887282-0	1987	Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter.	Tetradecanoylphorbol Acetate	84-120	epidermal growth factor receptor	Mus musculus	31-63
2887282-1	1987	Previous results have established that 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters can alter the properties of the epidermal growth factor (EGF) receptor through activation of protein kinase C. In order to determine whether other, non-TPA-type tumor promoters might similarly influence growth-mediating receptors, we investigated the effect of palytoxin on EGF binding in Swiss 3T3 fibroblasts and human epidermal carcinoma (A431) cells.	Tetradecanoylphorbol Acetate	39-75	epidermal growth factor receptor	Mus musculus	135-173
2887282-1	1987	Previous results have established that 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters can alter the properties of the epidermal growth factor (EGF) receptor through activation of protein kinase C. In order to determine whether other, non-TPA-type tumor promoters might similarly influence growth-mediating receptors, we investigated the effect of palytoxin on EGF binding in Swiss 3T3 fibroblasts and human epidermal carcinoma (A431) cells.	Tetradecanoylphorbol Acetate	77-80	epidermal growth factor receptor	Mus musculus	135-173
3115797-3	1987	The phorbol ester TPA and the adenylate cyclase activator forskolin reduced the c-myc RNA, levels and after 3 days of treatment a proportion of the cells accumulated in G1.	Tetradecanoylphorbol Acetate	18-21	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	80-85
3654756-16	1987	TPA reversibly blocks incorporation of [35S]methionine into myofibrillar alpha-actin, MHC, myosin light chains 1 and 2, the tropomyosins, and troponin C. It does not block the synthesis of beta- or gamma-actins, the nonmyofibrillar MHC or light chains, tubulin, vimentin, desmin, or most household molecules.	Tetradecanoylphorbol Acetate	0-3	myosin light chain 1	Homo sapiens	91-118
3654756-16	1987	TPA reversibly blocks incorporation of [35S]methionine into myofibrillar alpha-actin, MHC, myosin light chains 1 and 2, the tropomyosins, and troponin C. It does not block the synthesis of beta- or gamma-actins, the nonmyofibrillar MHC or light chains, tubulin, vimentin, desmin, or most household molecules.	Tetradecanoylphorbol Acetate	0-3	vimentin	Homo sapiens	262-270
3654756-16	1987	TPA reversibly blocks incorporation of [35S]methionine into myofibrillar alpha-actin, MHC, myosin light chains 1 and 2, the tropomyosins, and troponin C. It does not block the synthesis of beta- or gamma-actins, the nonmyofibrillar MHC or light chains, tubulin, vimentin, desmin, or most household molecules.	Tetradecanoylphorbol Acetate	0-3	desmin	Homo sapiens	272-278
2957433-11	1987	Checking the state of activation of rIFN-gamma-activated macrophages on the basis of two commonly used criteria for macrophage activation showed that rIFN-gamma-activated macrophages inhibited the intracellular replication of Toxoplasma gondii and displayed enhanced O2 consumption and H2O2 release after stimulation with phorbol myristate acetate compared with macrophages from normal CBA and C57BL/10 mice.	Tetradecanoylphorbol Acetate	322-347	interferon gamma	Rattus norvegicus	36-46
2957433-11	1987	Checking the state of activation of rIFN-gamma-activated macrophages on the basis of two commonly used criteria for macrophage activation showed that rIFN-gamma-activated macrophages inhibited the intracellular replication of Toxoplasma gondii and displayed enhanced O2 consumption and H2O2 release after stimulation with phorbol myristate acetate compared with macrophages from normal CBA and C57BL/10 mice.	Tetradecanoylphorbol Acetate	322-347	interferon gamma	Rattus norvegicus	150-160
3114254-6	1987	The GnRH effect was mimicked by the calcium- and phospholipid-dependent protein kinase C activator, phorbol myristate acetate.	Tetradecanoylphorbol Acetate	100-125	gonadotropin releasing hormone 1	Rattus norvegicus	4-8
3111768-15	1987	In contrast to lectins and anti-CD3 mAb phorbol-12-myristate-13-acetate (PMA) induced on its own a modest proliferative response which was greatly enhanced by r-h IL-1 independent of the addition of monocytes.	Tetradecanoylphorbol Acetate	40-71	interleukin 1 alpha	Homo sapiens	163-167
3111768-15	1987	In contrast to lectins and anti-CD3 mAb phorbol-12-myristate-13-acetate (PMA) induced on its own a modest proliferative response which was greatly enhanced by r-h IL-1 independent of the addition of monocytes.	Tetradecanoylphorbol Acetate	73-76	interleukin 1 alpha	Homo sapiens	163-167
2957212-8	1987	In Ichikawa cells, however, PMA induced surface expression of a mature T3/TCR complex.	Tetradecanoylphorbol Acetate	28-31	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	74-77
3497177-6	1987	Cultured human keratinocytes contain detectable amounts of IL-1 alpha and beta mRNA and protein in the absence of apparent stimulation; these levels could be significantly enhanced 6 h after exposure to 10 ng/ml of 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	215-252	interleukin 1 alpha	Homo sapiens	59-69
3497177-6	1987	Cultured human keratinocytes contain detectable amounts of IL-1 alpha and beta mRNA and protein in the absence of apparent stimulation; these levels could be significantly enhanced 6 h after exposure to 10 ng/ml of 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	254-257	interleukin 1 alpha	Homo sapiens	59-69
3297204-13	1987	On the other hand, a concentration of phorbol myristate acetate (TPA) that evokes full platelet aggregation and secretion induced maximal PAC1 and S12 binding.	Tetradecanoylphorbol Acetate	38-63	ADCYAP receptor type I	Homo sapiens	138-142
3297204-13	1987	On the other hand, a concentration of phorbol myristate acetate (TPA) that evokes full platelet aggregation and secretion induced maximal PAC1 and S12 binding.	Tetradecanoylphorbol Acetate	65-68	ADCYAP receptor type I	Homo sapiens	138-142
2438334-1	1987	Cross-linking of cell surface Ly-6C molecules with the 6C3 rat monoclonal antibody (MAb) followed by anti-rat immunoglobulin antibody acts in concert with phorbol myristate acetate (PMA) as a potent mitogenic stimulus for normal T cells.	Tetradecanoylphorbol Acetate	155-180	lymphocyte antigen 6 complex, locus C1	Mus musculus	30-35
2438334-1	1987	Cross-linking of cell surface Ly-6C molecules with the 6C3 rat monoclonal antibody (MAb) followed by anti-rat immunoglobulin antibody acts in concert with phorbol myristate acetate (PMA) as a potent mitogenic stimulus for normal T cells.	Tetradecanoylphorbol Acetate	182-185	lymphocyte antigen 6 complex, locus C1	Mus musculus	30-35
3498001-1	1987	12-O-Tetradecanoylphorbol 13-acetate (TPA) is a potent tumour promoter and shows several biological activities of epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	0-36	epidermal growth factor	Homo sapiens	114-137
3498001-1	1987	12-O-Tetradecanoylphorbol 13-acetate (TPA) is a potent tumour promoter and shows several biological activities of epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	38-41	epidermal growth factor	Homo sapiens	114-137
3110603-8	1987	Phosphorylation of the c-fos protein, but not the v-fos protein, can be stimulated at least fivefold in vivo by the addition of either 12-tetradecanoyl-phorbol-13-acetate or serum.	Tetradecanoylphorbol Acetate	135-170	FBJ osteosarcoma oncogene	Mus musculus	23-28
3110603-8	1987	Phosphorylation of the c-fos protein, but not the v-fos protein, can be stimulated at least fivefold in vivo by the addition of either 12-tetradecanoyl-phorbol-13-acetate or serum.	Tetradecanoylphorbol Acetate	135-170	FBJ osteosarcoma oncogene	Mus musculus	25-28
3032312-6	1987	It could be demonstrated that the r.GM-CSF, as well as the UBC-CM, induce an activation of the neutrophil respiratory burst without any cofactors such as f-MLP, PMA, or zymosan.	Tetradecanoylphorbol Acetate	161-164	colony stimulating factor 2	Homo sapiens	36-42
3494622-5	1987	Prolonged treatment of the cells with TPA, which causes a selective decrease in protein kinase C activity, partially inhibited the induction of c-fos and c-myc gene expression by bombesin, similar to what has been observed with PDGF.	Tetradecanoylphorbol Acetate	38-41	FBJ osteosarcoma oncogene	Mus musculus	144-149
3106489-8	1987	CD5-stimulated calcium mobilization also differed from CD3 in that the CD5 response was inhibited by pretreatment with phorbol myristate acetate, whereas the CD3 response was not, suggesting that depletion of protein kinase C causes an uncoupling of signal transduction between CD5 and calcium channels.	Tetradecanoylphorbol Acetate	119-144	CD5 molecule	Homo sapiens	0-3
3106489-8	1987	CD5-stimulated calcium mobilization also differed from CD3 in that the CD5 response was inhibited by pretreatment with phorbol myristate acetate, whereas the CD3 response was not, suggesting that depletion of protein kinase C causes an uncoupling of signal transduction between CD5 and calcium channels.	Tetradecanoylphorbol Acetate	119-144	CD5 molecule	Homo sapiens	71-74
3106489-8	1987	CD5-stimulated calcium mobilization also differed from CD3 in that the CD5 response was inhibited by pretreatment with phorbol myristate acetate, whereas the CD3 response was not, suggesting that depletion of protein kinase C causes an uncoupling of signal transduction between CD5 and calcium channels.	Tetradecanoylphorbol Acetate	119-144	CD5 molecule	Homo sapiens	71-74
2435803-3	1987	Expression of the 15TD3 antigen and vimentin was induced simultaneously in some EBV genome-positive cell lines either by EBV superinfection or by 12-0-tetradecanoyl-1-phorbol-13-acetate (TPA) and n-butyrate treatment.	Tetradecanoylphorbol Acetate	187-190	vimentin	Homo sapiens	36-44
3104333-14	1987	Our results suggest that the stimulation of phospholipase A2 activity by TPA occurs via activation of protein kinase C by TPA.	Tetradecanoylphorbol Acetate	73-76	phospholipase A2 group IB	Canis lupus familiaris	44-60
3104333-14	1987	Our results suggest that the stimulation of phospholipase A2 activity by TPA occurs via activation of protein kinase C by TPA.	Tetradecanoylphorbol Acetate	122-125	phospholipase A2 group IB	Canis lupus familiaris	44-60
3106083-3	1987	On the other hand, TPA was effective only at dosages greater than 10(-6)M. These results suggest that the stimulatory effect of LHRH on arachidonic acid release is coupled more tightly to a Ca2+-dependent rather than a protein kinase C-mediated pathway.	Tetradecanoylphorbol Acetate	19-22	gonadotropin releasing hormone 1	Rattus norvegicus	128-132
3109389-2	1987	TRH, which was minimally effective at around 10(-9) M, and TPA, 100 nM, produced very small elevations in pHi of about 0.05 pH units from the normal basal resting pHi of GH4C1 cells of around 7.05.	Tetradecanoylphorbol Acetate	59-62	glucose-6-phosphate isomerase	Rattus norvegicus	106-109
3109389-2	1987	TRH, which was minimally effective at around 10(-9) M, and TPA, 100 nM, produced very small elevations in pHi of about 0.05 pH units from the normal basal resting pHi of GH4C1 cells of around 7.05.	Tetradecanoylphorbol Acetate	59-62	glucose-6-phosphate isomerase	Rattus norvegicus	163-166
2433285-6	1987	The EGF-dependent increases in both inositol triphosphate production and phosphatidylinositol 4-monophosphate levels were inhibited by pretreatment of the cells with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	166-202	epidermal growth factor	Homo sapiens	4-7
2948635-5	1987	Nuclear run-on assays showed that E1 transcription, as well as transcription of c-fos, c-myc, and beta-actin was stimulated in 293 cells within 30 min of TPA exposure and returned to basal levels by 60 min.	Tetradecanoylphorbol Acetate	154-157	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	87-92
3104061-5	1987	Either accessory cells, RIF or the protein kinase C activator phorbol myristate acetate can substitute for each other and are equally active for the induction of IL 2 responsiveness in high-density Lyt-2+ T cells exposed to Con A.	Tetradecanoylphorbol Acetate	62-87	interleukin 2	Mus musculus	162-166
3802391-0	1987	Inhibition by indomethacin and 5,8,11,14-eicosatetraynoic acid of the induction of rat hepatic ornithine decarboxylase by the tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in vivo.	Tetradecanoylphorbol Acetate	160-196	ornithine decarboxylase 1	Rattus norvegicus	95-118
3802391-1	1987	The involvement of arachidonate metabolism in the induction of rat hepatic ornithine decarboxylase (ODC) activity by the tumor promoters 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) was investigated.	Tetradecanoylphorbol Acetate	137-173	ornithine decarboxylase 1	Rattus norvegicus	75-98
3802391-1	1987	The involvement of arachidonate metabolism in the induction of rat hepatic ornithine decarboxylase (ODC) activity by the tumor promoters 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) was investigated.	Tetradecanoylphorbol Acetate	137-173	ornithine decarboxylase 1	Rattus norvegicus	100-103
3802391-1	1987	The involvement of arachidonate metabolism in the induction of rat hepatic ornithine decarboxylase (ODC) activity by the tumor promoters 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) was investigated.	Tetradecanoylphorbol Acetate	175-178	ornithine decarboxylase 1	Rattus norvegicus	75-98
3802391-1	1987	The involvement of arachidonate metabolism in the induction of rat hepatic ornithine decarboxylase (ODC) activity by the tumor promoters 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) was investigated.	Tetradecanoylphorbol Acetate	175-178	ornithine decarboxylase 1	Rattus norvegicus	100-103
3802391-3	1987	Both inhibitors were more potent inhibitors of PB induction than TPA induction of ODC.	Tetradecanoylphorbol Acetate	65-68	ornithine decarboxylase 1	Rattus norvegicus	82-85
3311846-1	1987	Endothelial cell activation by endotoxin (LPS), tumor necrosis factor (TNF), Interleukin-1-alpha, beta (IL-1-alpha, beta) and phorbolesters (TPA) results in increased monocyte adhesion.	Tetradecanoylphorbol Acetate	141-144	interleukin 1 alpha	Homo sapiens	104-114
3311846-3	1987	Monoclonal antibody (4D10), raised against 24 h LPS-stimulated endothelial cells detects an endothelial cell-specific activation antigen at Mr 81,000 that is induced by LPS, TNF, IL-1-alpha, beta and TPA (within 6 h about 100% positive cells).	Tetradecanoylphorbol Acetate	200-203	interferon regulatory factor 6	Homo sapiens	48-51
2891591-0	1987	Dipeptidyl peptidase IV activity in cells of T-lymphoid origin is decreased in cultures with 12-0-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	131-134	dipeptidyl peptidase 4	Homo sapiens	0-23
2891591-2	1987	It has been attempted to induce DPP IV activity in DPP IV negative T-lymphoid leukaemias by 12-o-tetradecanoylphrobol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	130-133	dipeptidyl peptidase 4	Homo sapiens	32-38
2891591-2	1987	It has been attempted to induce DPP IV activity in DPP IV negative T-lymphoid leukaemias by 12-o-tetradecanoylphrobol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	130-133	dipeptidyl peptidase 4	Homo sapiens	51-57
2891591-4	1987	The percentage of DPP IV positive lymphocytes from blood donors remained unchanged in control and HPCM cultures, but decreased significantly in TPA cultures.	Tetradecanoylphorbol Acetate	144-147	dipeptidyl peptidase 4	Homo sapiens	18-24
2891591-5	1987	Leukemic cells from three DPP IV positive cases of acute T-lymphoblastic leukaemia (T-ALL) reacted to the TPA treatment in a similar manner.	Tetradecanoylphorbol Acetate	106-109	dipeptidyl peptidase 4	Homo sapiens	26-32
3110173-6	1987	Cells prelabeled with 3H-choline released choline, choline phosphate and CDP-choline upon TPA but not upon A 23187 treatment.	Tetradecanoylphorbol Acetate	90-93	cut-like homeobox 1	Mus musculus	73-76
3769135-1	1986	12-O-Tetradecanoylphorbol-13 acetate (TPA) or various acylglycerols were applied topically to CD-1 mice, and biochemical changes associated with tumor promotion in the epidermis were examined.	Tetradecanoylphorbol Acetate	0-36	CD1 antigen complex	Mus musculus	94-98
3095338-1	1986	12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter, acts similarly to growth factors by selectively increasing the rate of production of the secreted proteins, mitogen regulated protein (MRP) and major excreted protein (MEP) by murine 3T3 cells.	Tetradecanoylphorbol Acetate	0-36	cathepsin L	Mus musculus	213-235
3095338-1	1986	12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter, acts similarly to growth factors by selectively increasing the rate of production of the secreted proteins, mitogen regulated protein (MRP) and major excreted protein (MEP) by murine 3T3 cells.	Tetradecanoylphorbol Acetate	0-36	cathepsin L	Mus musculus	237-240
3095338-1	1986	12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter, acts similarly to growth factors by selectively increasing the rate of production of the secreted proteins, mitogen regulated protein (MRP) and major excreted protein (MEP) by murine 3T3 cells.	Tetradecanoylphorbol Acetate	38-41	cathepsin L	Mus musculus	213-235
3095338-1	1986	12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter, acts similarly to growth factors by selectively increasing the rate of production of the secreted proteins, mitogen regulated protein (MRP) and major excreted protein (MEP) by murine 3T3 cells.	Tetradecanoylphorbol Acetate	38-41	cathepsin L	Mus musculus	237-240
3095338-9	1986	In summary, the ability to TPA and teleocidin to increase the rate of production of MRP and MEP correlated with the ability of these tumor promoters to stimulate DNA synthesis in quiescent 3T3 and TNR-9 cells.	Tetradecanoylphorbol Acetate	27-30	cathepsin L	Mus musculus	92-95
3022291-7	1986	Serum and the phorbol ester tumor promoter phorbol 12-myristate 13-acetate also enhanced c-myc expression in cardiac myocyte cultures.	Tetradecanoylphorbol Acetate	43-74	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	89-94
3758353-2	1986	When phorbol 12-myristate 13-acetate (PMA) was added to washed platelet suspensions 10 s prior to either thrombin or ADP, it caused a dose-dependent inhibition of shape change correlated with decreased myosin association with the cytoskeleton and with inhibition of the calcium transient measured in fura-2-loaded platelets.	Tetradecanoylphorbol Acetate	5-36	myosin heavy chain 14	Homo sapiens	202-208
3758353-2	1986	When phorbol 12-myristate 13-acetate (PMA) was added to washed platelet suspensions 10 s prior to either thrombin or ADP, it caused a dose-dependent inhibition of shape change correlated with decreased myosin association with the cytoskeleton and with inhibition of the calcium transient measured in fura-2-loaded platelets.	Tetradecanoylphorbol Acetate	38-41	myosin heavy chain 14	Homo sapiens	202-208
3093371-2	1986	Induction of IL-2 receptor (IL-2R), IL-2 production and subsequent de novo DNA synthesis in MRL/l mice by the tumour-promoting phorbol ester 12-o-tetradecanoyl phorbol 13-acetate (TPA) and calcium ionophore (A23187) were examined.	Tetradecanoylphorbol Acetate	141-178	interleukin 2	Mus musculus	13-17
3747550-2	1986	In the hairless rat skin, ornithine decarboxylase activity was induced by ten successive strippings with cellotape and by topical application of 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	145-182	ornithine decarboxylase 1	Rattus norvegicus	26-49
3015918-5	1986	This is inhibited when TPA-treated cells are exposed to EGF.	Tetradecanoylphorbol Acetate	23-26	epidermal growth factor	Homo sapiens	56-59
3015918-10	1986	Indeed, we find that 12-O-tetradecanoylphorbol-13-acetate, added 10 min after EGF, further increases threonine 654 phosphorylation and induces the loss of tyrosine phosphate from A431 cell EGF receptors.	Tetradecanoylphorbol Acetate	21-57	epidermal growth factor	Homo sapiens	78-81
3015918-10	1986	Indeed, we find that 12-O-tetradecanoylphorbol-13-acetate, added 10 min after EGF, further increases threonine 654 phosphorylation and induces the loss of tyrosine phosphate from A431 cell EGF receptors.	Tetradecanoylphorbol Acetate	21-57	epidermal growth factor	Homo sapiens	189-192
3015383-2	1986	EGF or TPA induced a 4- to 6-fold increase in the phosphorylation of pp17 and a 2- to 4-fold increase in the phosphorylation of pp27, pp34, and pp80 within 15 min after treatment of subconfluent A431 cells.	Tetradecanoylphorbol Acetate	7-10	stathmin 1	Homo sapiens	69-73
3093404-5	1986	Addition of a calcium ionophore (A23187) to cultures containing TPA plus PRL increased ornithine decarboxylase above PRL alone or PRL plus TPA but inhibited proliferation compared to the PRL plus TPA regimen.	Tetradecanoylphorbol Acetate	64-67	ornithine decarboxylase 1	Rattus norvegicus	87-110
3011686-1	1986	To elucidate the biological mechanisms of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phenotypic changes in HTLV-I virus-infected human T-cell line KH-2Lo cells, inhibitors of TPA-induced ornithine decarboxylase (ODC), protein kinases and calmodulin were examined for their effects on TPA-induced multinucleated cell formation and HTLV-I p19 antigen expression.	Tetradecanoylphorbol Acetate	80-83	interleukin 23 subunit alpha	Homo sapiens	345-348
3011686-5	1986	1,25(OH)2D3 and its active analogues inhibited both TPA-induced HTLV-I p19 antigen expression and multinucleated cell formation after 4 days of culture with TPA.	Tetradecanoylphorbol Acetate	52-55	interleukin 23 subunit alpha	Homo sapiens	71-74
3011686-6	1986	On the other hand, an inhibitor of ODC, DFMO, the protein kinase inhibitors, the calmodulin inhibitor and retinoic acid suppressed TPA-induced HTLV-I p19 expression but did not suppress multinucleated cell formation.	Tetradecanoylphorbol Acetate	131-134	interleukin 23 subunit alpha	Homo sapiens	150-153
3458169-1	1986	The effect of phorbol 12-myristate 13-acetate (PMA) on diacylglycerol lipase activity was examined in rat serum, tissue, and cellular preparations by using di[14C]oleoylglycerol, [3H]palmitoylacetylglycerol, and membrane-resident phospholipase C-generated diacylglycerols as substrates.	Tetradecanoylphorbol Acetate	14-45	lipase G, endothelial type	Rattus norvegicus	70-76
3458169-1	1986	The effect of phorbol 12-myristate 13-acetate (PMA) on diacylglycerol lipase activity was examined in rat serum, tissue, and cellular preparations by using di[14C]oleoylglycerol, [3H]palmitoylacetylglycerol, and membrane-resident phospholipase C-generated diacylglycerols as substrates.	Tetradecanoylphorbol Acetate	47-50	lipase G, endothelial type	Rattus norvegicus	70-76
3458169-6	1986	PMA was likewise inhibitory when assayed in an intramembrane enzyme-substrate milieu in which diacylglycerols were generated, in situ, by treatment of [3H]palmitate-labeled cell homogenates with phospholipase C. Collectively, these data demonstrate that PMA, which is now thought to act by mimicry of diacylglycerols, can inhibit the action of diacylglycerol lipase.	Tetradecanoylphorbol Acetate	0-3	lipase G, endothelial type	Rattus norvegicus	202-208
3006836-4	1986	Mean percentage of enhancement by 10(-5) mol/L of PAF was 297% +/- 35% (n = 9) of control responses to FMLP and 185% +/- 16% (n = 3) of control responses to PMA.	Tetradecanoylphorbol Acetate	157-160	PCNA clamp associated factor	Homo sapiens	50-53
2427445-1	1986	The thymic leukemia cell line EL4 has been shown to produce the lymphokine Interleukin-2 (IL-2) following stimulation with phorbol ester (PMA).	Tetradecanoylphorbol Acetate	138-141	interleukin 2	Mus musculus	75-88
2427445-1	1986	The thymic leukemia cell line EL4 has been shown to produce the lymphokine Interleukin-2 (IL-2) following stimulation with phorbol ester (PMA).	Tetradecanoylphorbol Acetate	138-141	interleukin 2	Mus musculus	90-94
3958045-2	1986	In urokinase-producing human carcinoma cells (A1251), a 20-40-fold increase in urokinase mRNA level is obtained after treatment with 10 nM phorbol myristate acetate (PMA), a smaller effect (two- to fourfold) with 2 ng/ml platelet-derived growth factor (PDGF) and no effect with epidermal growth factor (EGF) (up to 50 nM).	Tetradecanoylphorbol Acetate	139-164	epidermal growth factor	Homo sapiens	278-301
3958045-2	1986	In urokinase-producing human carcinoma cells (A1251), a 20-40-fold increase in urokinase mRNA level is obtained after treatment with 10 nM phorbol myristate acetate (PMA), a smaller effect (two- to fourfold) with 2 ng/ml platelet-derived growth factor (PDGF) and no effect with epidermal growth factor (EGF) (up to 50 nM).	Tetradecanoylphorbol Acetate	139-164	epidermal growth factor	Homo sapiens	303-306
3958045-2	1986	In urokinase-producing human carcinoma cells (A1251), a 20-40-fold increase in urokinase mRNA level is obtained after treatment with 10 nM phorbol myristate acetate (PMA), a smaller effect (two- to fourfold) with 2 ng/ml platelet-derived growth factor (PDGF) and no effect with epidermal growth factor (EGF) (up to 50 nM).	Tetradecanoylphorbol Acetate	166-169	epidermal growth factor	Homo sapiens	278-301
3958045-2	1986	In urokinase-producing human carcinoma cells (A1251), a 20-40-fold increase in urokinase mRNA level is obtained after treatment with 10 nM phorbol myristate acetate (PMA), a smaller effect (two- to fourfold) with 2 ng/ml platelet-derived growth factor (PDGF) and no effect with epidermal growth factor (EGF) (up to 50 nM).	Tetradecanoylphorbol Acetate	166-169	epidermal growth factor	Homo sapiens	303-306
3005408-2	1986	Specifically, the pharmacologic PKC activator phorbol myristate acetate mimics the biologic effects of mIg cross-linking ligands, and cross-linking of membrane Ig (mIg) induces polyphosphoinositide hydrolysis generating diacylglycerol, a potent activator of PKC.	Tetradecanoylphorbol Acetate	46-71	chemokine (C-X-C motif) ligand 9	Mus musculus	103-106
3005408-2	1986	Specifically, the pharmacologic PKC activator phorbol myristate acetate mimics the biologic effects of mIg cross-linking ligands, and cross-linking of membrane Ig (mIg) induces polyphosphoinositide hydrolysis generating diacylglycerol, a potent activator of PKC.	Tetradecanoylphorbol Acetate	46-71	chemokine (C-X-C motif) ligand 9	Mus musculus	104-106
3511049-1	1986	Malignant transformation of mouse cells by a variety of agents or treatment with the tumor promoter 12-O-tetradecanoylphorbol 13-acetate or platelet-derived growth factor results in increased synthesis and secretion of a 39,000-dalton protein termed major excreted protein (MEP).	Tetradecanoylphorbol Acetate	100-136	cathepsin L	Mus musculus	250-272
3511049-1	1986	Malignant transformation of mouse cells by a variety of agents or treatment with the tumor promoter 12-O-tetradecanoylphorbol 13-acetate or platelet-derived growth factor results in increased synthesis and secretion of a 39,000-dalton protein termed major excreted protein (MEP).	Tetradecanoylphorbol Acetate	100-136	cathepsin L	Mus musculus	274-277
3000588-6	1986	In fact, TPA appeared to inhibit the mitogenic effects of EGF.	Tetradecanoylphorbol Acetate	9-12	epidermal growth factor	Canis lupus familiaris	58-61
3083761-9	1986	The antigen-exogenous IL2-driven pathway of HILDA production by clones was bypassed by use of either PMA or calcium ionophore (CaI) alone or associated in the culture.	Tetradecanoylphorbol Acetate	101-104	LIF interleukin 6 family cytokine	Homo sapiens	44-49
2868750-2	1986	TPA is a potent tumour promoter and treatment with this compound of the two cell lines induced peroxisomal fatty acid beta-oxidation, carnitine acetyltransferase, palmitoyl-CoA hydrolase, and catalase activities after 240 h of treatment.	Tetradecanoylphorbol Acetate	0-3	carnitine acetyltransferase	Mus musculus	134-161
3081352-2	1986	The combination of phorbol myristate acetate (PMA), ionomycin and recombinant interleukin 2 (IL2) is both sufficient and necessary to induce growth of about 1/6.2 (range 1/3-1/9) and 1/4.3 (range 1/2-1/7) immature thymocytes from adult and fetal mice, respectively, in serum-free cultures.	Tetradecanoylphorbol Acetate	19-44	interleukin 2	Mus musculus	93-96
3079612-6	1986	The (Ca++)i response cannot be induced by activation of protein kinase C (PKC) with phorbol diesters (e.g., PMA) or synthetic diacylglycerol (DAG), suggesting that this response precedes the PKC activation.	Tetradecanoylphorbol Acetate	108-111	carbonic anhydrase 1	Mus musculus	5-11
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Tetradecanoylphorbol Acetate	58-61	complement C4A (Rodgers blood group)	Homo sapiens	70-73
2939645-0	1986	Transformation-related cellular protein p53: increased level in untransformed rat cells following treatment with the tumorpromoter, tetradecanoylphorbol-acetate.	Tetradecanoylphorbol Acetate	132-160	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	40-43
2939645-1	1986	12-O-Tetradecanoylphorbol-13-acetate (TPA, 100 ng ml-1), a tumor promoting phorbol ester, is able to induce enhanced levels of the transformation-associated cellular antigen p53 in normal rat 2 cells which had not been previously initiated by a carcinogen.	Tetradecanoylphorbol Acetate	0-36	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	174-177
2939645-1	1986	12-O-Tetradecanoylphorbol-13-acetate (TPA, 100 ng ml-1), a tumor promoting phorbol ester, is able to induce enhanced levels of the transformation-associated cellular antigen p53 in normal rat 2 cells which had not been previously initiated by a carcinogen.	Tetradecanoylphorbol Acetate	38-41	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	174-177
3932087-6	1985	Exposure of myeloblasts to CSF induced increased triatiated thymidine (3H-TdR) incorporation within a few hours, while TPA did not induce 3H-TdR incorporation by itself and was inhibitory to CSF-induced 3H-TdR uptake.	Tetradecanoylphorbol Acetate	119-122	colony stimulating factor 2	Homo sapiens	191-194
3875657-1	1985	BSF-1 was partially purified from serum-free culture supernatants of cells of the EL-4 thymoma line, which had been induced 48 hr earlier with 4 beta-phorbol-12 beta-myristate-12 alpha-acetate (PMA).	Tetradecanoylphorbol Acetate	194-197	interleukin 4	Mus musculus	0-5
4028331-5	1985	Pre-exposure of cells to PMA increased the recovery of both post-PMA-treated and non-treated HGPRT- cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	25-28	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	93-98
3876342-11	1985	Furthermore, the degree of TPA-induced CSF-1-receptor down-regulation is closely associated with the number of available phorbol ester receptors present on PEM at the time of treatment.	Tetradecanoylphorbol Acetate	27-30	colony stimulating factor 1 receptor	Mus musculus	39-53
3876342-13	1985	A 72-hr incubation time at 37 degrees C was needed for PEM to lose their refractoriness and again become fully sensitive to TPA-induced CSF-1-receptor down-regulation.	Tetradecanoylphorbol Acetate	124-127	colony stimulating factor 1 receptor	Mus musculus	136-150
3159791-3	1985	In this study, by using radiolabeled Fab fragments of a monoclonal anti-CR1 antibody to tag the receptor and acid elution of surface-bound Fab, we showed that both phorbol myristate acetate and phorbol dibutyrate induced internalization of the C3b receptor; this occurred in a dose- and time-dependent manner in the absence of occupancy of the receptor by ligand.	Tetradecanoylphorbol Acetate	164-189	FA complementation group B	Homo sapiens	37-40
3159791-3	1985	In this study, by using radiolabeled Fab fragments of a monoclonal anti-CR1 antibody to tag the receptor and acid elution of surface-bound Fab, we showed that both phorbol myristate acetate and phorbol dibutyrate induced internalization of the C3b receptor; this occurred in a dose- and time-dependent manner in the absence of occupancy of the receptor by ligand.	Tetradecanoylphorbol Acetate	164-189	FA complementation group B	Homo sapiens	139-142
3921556-2	1985	12-O-Tetradecanoylphorbol-13-acetate (TPA) induces ODC activity in these cells in a dose-and time-dependent manner.	Tetradecanoylphorbol Acetate	0-36	ornithine decarboxylase 1	Rattus norvegicus	51-54
3921556-2	1985	12-O-Tetradecanoylphorbol-13-acetate (TPA) induces ODC activity in these cells in a dose-and time-dependent manner.	Tetradecanoylphorbol Acetate	38-41	ornithine decarboxylase 1	Rattus norvegicus	51-54
3921556-10	1985	The induction of ODC by TPA as well as by phospholipase C is inhibited by retinoids.	Tetradecanoylphorbol Acetate	24-27	ornithine decarboxylase 1	Rattus norvegicus	17-20
3872909-9	1985	It was also found that 12-O-tetradecanoyl-phorbol 13-acetate (TPA) switched 23A4 cells and normal lymphocytes to the selective formation of N-glycosylated IgE-binding factor, and induced the release of GIF from the cells.	Tetradecanoylphorbol Acetate	23-60	cobalamin binding intrinsic factor	Homo sapiens	202-205
3872909-9	1985	It was also found that 12-O-tetradecanoyl-phorbol 13-acetate (TPA) switched 23A4 cells and normal lymphocytes to the selective formation of N-glycosylated IgE-binding factor, and induced the release of GIF from the cells.	Tetradecanoylphorbol Acetate	62-65	cobalamin binding intrinsic factor	Homo sapiens	202-205
3979448-2	1985	The development of functional Fc receptors (FcR) during induced differentiation with the tumor promoter, phorbol myristate acetate (PMA), was studied in the murine tumor cell line, P388.	Tetradecanoylphorbol Acetate	105-130	Fc receptor	Mus musculus	30-42
3979448-2	1985	The development of functional Fc receptors (FcR) during induced differentiation with the tumor promoter, phorbol myristate acetate (PMA), was studied in the murine tumor cell line, P388.	Tetradecanoylphorbol Acetate	105-130	Fc receptor	Mus musculus	44-47
3979448-2	1985	The development of functional Fc receptors (FcR) during induced differentiation with the tumor promoter, phorbol myristate acetate (PMA), was studied in the murine tumor cell line, P388.	Tetradecanoylphorbol Acetate	132-135	Fc receptor	Mus musculus	30-42
3979448-3	1985	PMA induced the appearance of FcR on the membranes of P388 cells as indicated by the binding of IgG-coated sheep red blood cells (IgG-SRBC).	Tetradecanoylphorbol Acetate	0-3	Fc receptor	Mus musculus	30-33
3838316-3	1985	There was approximately a 10-fold induction of vimentin biosynthesis following TPA treatment.	Tetradecanoylphorbol Acetate	79-82	vimentin	Homo sapiens	47-55
3838316-7	1985	A time course showed that vimentin mRNA activity was detectably elevated as early as 3 h after TPA treatment and reached a maximum by 12 h then the level decreased.	Tetradecanoylphorbol Acetate	95-98	vimentin	Homo sapiens	26-34
3838316-11	1985	These results are consistent with the induction of vimentin and actin gene transcription by TPA in K562 cells.	Tetradecanoylphorbol Acetate	92-95	vimentin	Homo sapiens	51-59
2578312-3	1985	Five days after the addition of either 180 mM dimethyl sulfoxide or 60 nM 12-O-tetradecanoylphorbol-13-acetate to HL-60 cultures, transcription of the c-myc gene was markedly reduced when compared with control cultures.	Tetradecanoylphorbol Acetate	74-110	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	151-156
3265471-7	1988	Treatment of resting T cells with ionomycin plus PMA resulted in a 60-fold increase in 4F2HC mRNA levels.	Tetradecanoylphorbol Acetate	49-52	solute carrier family 3 member 2	Homo sapiens	87-92
3265472-3	1988	However, in monocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA), CSF-1 mRNA was increased by 3 h and reached maximal levels by 12 h of drug exposure.	Tetradecanoylphorbol Acetate	35-71	colony stimulating factor 1	Homo sapiens	79-84
3265472-3	1988	However, in monocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA), CSF-1 mRNA was increased by 3 h and reached maximal levels by 12 h of drug exposure.	Tetradecanoylphorbol Acetate	73-76	colony stimulating factor 1	Homo sapiens	79-84
3265472-4	1988	When nuclear run-on assays were used, CSF-1 gene transcription was also at low or undetectable levels in resting monocytes but was activated after TPA exposure.	Tetradecanoylphorbol Acetate	147-150	colony stimulating factor 1	Homo sapiens	38-43
3265472-5	1988	TPA-treated monocytes exposed to actinomycin D further demonstrated that the half-life of the CSF-1 mRNA is 0.9 h. The results also demonstrated that the protein synthesis inhibitor, cycloheximide (CHX), increases CSF-1 mRNA levels in both resting and TPA-treated monocytes.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 1	Homo sapiens	94-99
3265472-5	1988	TPA-treated monocytes exposed to actinomycin D further demonstrated that the half-life of the CSF-1 mRNA is 0.9 h. The results also demonstrated that the protein synthesis inhibitor, cycloheximide (CHX), increases CSF-1 mRNA levels in both resting and TPA-treated monocytes.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 1	Homo sapiens	214-219
3265472-5	1988	TPA-treated monocytes exposed to actinomycin D further demonstrated that the half-life of the CSF-1 mRNA is 0.9 h. The results also demonstrated that the protein synthesis inhibitor, cycloheximide (CHX), increases CSF-1 mRNA levels in both resting and TPA-treated monocytes.	Tetradecanoylphorbol Acetate	252-255	colony stimulating factor 1	Homo sapiens	94-99
3390816-6	1988	The stimulated ODC activity in the cultured cells that followed treatment with a phorbol ester tumor promoter (12-O-tetradecanoylphorbol-13-acetate) was further potentiated by prior exposure to the same low energy electromagnetic field.	Tetradecanoylphorbol Acetate	111-147	ornithine decarboxylase 1	Rattus norvegicus	15-18
3390816-9	1988	Chinese hamster ovary cells exposed to the radio frequency field for 1 h also responded to subsequent treatment with 12-O-tetradecanoylphorbol-13-acetate by exhibiting a further increase in ODC activity.	Tetradecanoylphorbol Acetate	117-153	ornithine decarboxylase 1	Rattus norvegicus	190-193
2839040-7	1988	The diacylglycerol analogue, phorbol 12-myristate 13-acetate, increased both pHi and [3H]thymidine incorporation, and amiloride reduced both indexes.	Tetradecanoylphorbol Acetate	29-60	glucose-6-phosphate isomerase	Rattus norvegicus	77-80
3138977-9	1988	Treatment of the cells with 12-O-tetradecanoylphorbol 13-acetate completely abolishes the response to EGF and to sub-optimal doses of bradykinin, suggesting a negative-feedback function of protein kinase C. Pretreatment of the cells with pertussis toxin has no effect on inositol phosphate formation induced by either EGF or bradykinin.	Tetradecanoylphorbol Acetate	28-64	epidermal growth factor	Homo sapiens	102-105
3138977-9	1988	Treatment of the cells with 12-O-tetradecanoylphorbol 13-acetate completely abolishes the response to EGF and to sub-optimal doses of bradykinin, suggesting a negative-feedback function of protein kinase C. Pretreatment of the cells with pertussis toxin has no effect on inositol phosphate formation induced by either EGF or bradykinin.	Tetradecanoylphorbol Acetate	28-64	epidermal growth factor	Homo sapiens	318-321
3259577-13	1988	12-O-Tetradecanoylphorbol-13-acetate (TPA), an exogenous activator of Ca2+/phospholipid-dependent protein kinase (protein kinase C), causes a dramatic, but transient, inhibition of the EGF-stimulated formation of inositol phosphates.	Tetradecanoylphorbol Acetate	0-36	epidermal growth factor	Homo sapiens	185-188
3259577-13	1988	12-O-Tetradecanoylphorbol-13-acetate (TPA), an exogenous activator of Ca2+/phospholipid-dependent protein kinase (protein kinase C), causes a dramatic, but transient, inhibition of the EGF-stimulated formation of inositol phosphates.	Tetradecanoylphorbol Acetate	38-41	epidermal growth factor	Homo sapiens	185-188
1458488-3	1992	LIF mRNA expression was enhanced by interleukin 2 or 12-O-tetradecanoylphorbol-13-acetate in MT-2 cells.	Tetradecanoylphorbol Acetate	53-89	metallothionein 2A	Homo sapiens	93-97
1285021-4	1992	L2 cells produced tPA, which production was stimulated by retinoic acid, phorbol myristate acetate, butyrate and cAMP; serum factors blunted their response, whereas in the synthetic serum substituting medium Ultraculture and with cocktail Ultroser the action of tPA stimulators was enhanced.	Tetradecanoylphorbol Acetate	73-98	plasminogen activator, tissue type	Rattus norvegicus	18-21
3132170-1	1988	Casein-elicited mouse peritoneal macrophages cultured in the presence of phorbol 12-myristate 13-acetate (PMA) express u-PA.	Tetradecanoylphorbol Acetate	73-104	plasminogen activator, urokinase	Mus musculus	119-123
3132170-1	1988	Casein-elicited mouse peritoneal macrophages cultured in the presence of phorbol 12-myristate 13-acetate (PMA) express u-PA.	Tetradecanoylphorbol Acetate	106-109	plasminogen activator, urokinase	Mus musculus	119-123
3258542-8	1988	It was also determined that the phorbol ester 12-O-tetradecanoylphorbol-13-acetate reduces EGF binding to the high affinity receptors of A-431R-1 cells; whereas, transforming growth factor type beta did not significantly affect EGF binding.	Tetradecanoylphorbol Acetate	46-82	epidermal growth factor	Homo sapiens	91-94
1280205-3	1992	The addition of 10(-7) M 4 beta-phorbol 12-myristate 13-acetate (PMA) to HEC-50 and HEC-1B cells resulted in changes in cell morphology, growth inhibition, activation of PKC, and an increase in expression of IGFBP-1.	Tetradecanoylphorbol Acetate	25-63	insulin like growth factor binding protein 1	Homo sapiens	208-215
1280205-3	1992	The addition of 10(-7) M 4 beta-phorbol 12-myristate 13-acetate (PMA) to HEC-50 and HEC-1B cells resulted in changes in cell morphology, growth inhibition, activation of PKC, and an increase in expression of IGFBP-1.	Tetradecanoylphorbol Acetate	65-68	insulin like growth factor binding protein 1	Homo sapiens	208-215
3282677-1	1988	Memory lymphocytic choriomeningitis virus (LCMV)-immune cytotoxic T-lymphocyte precursors (CTLp) can be stimulated to proliferate and to mediate specific cytotoxic activity following incubation with phorbol myristate acetate (PMA), calcium ionophore (CaI), and interleukin 2 (IL-2).	Tetradecanoylphorbol Acetate	199-224	interleukin 2	Mus musculus	276-280
3918270-6	1985	However, either one in combination with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), which is structurally related to 1,2-diacylglycerol, induces in lymphoid cell populations the expression of receptors for interleukin-2 (IL-2), the secretion of IL-2 and cell proliferation as measured by 3H-thymidine uptake.	Tetradecanoylphorbol Acetate	58-94	interleukin 2	Mus musculus	224-237
1333046-0	1992	Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP.	Tetradecanoylphorbol Acetate	62-87	NCK adaptor protein 1	Homo sapiens	19-22
3918270-6	1985	However, either one in combination with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), which is structurally related to 1,2-diacylglycerol, induces in lymphoid cell populations the expression of receptors for interleukin-2 (IL-2), the secretion of IL-2 and cell proliferation as measured by 3H-thymidine uptake.	Tetradecanoylphorbol Acetate	58-94	interleukin 2	Mus musculus	239-243
3918270-6	1985	However, either one in combination with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), which is structurally related to 1,2-diacylglycerol, induces in lymphoid cell populations the expression of receptors for interleukin-2 (IL-2), the secretion of IL-2 and cell proliferation as measured by 3H-thymidine uptake.	Tetradecanoylphorbol Acetate	58-94	interleukin 2	Mus musculus	263-267
3918270-6	1985	However, either one in combination with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), which is structurally related to 1,2-diacylglycerol, induces in lymphoid cell populations the expression of receptors for interleukin-2 (IL-2), the secretion of IL-2 and cell proliferation as measured by 3H-thymidine uptake.	Tetradecanoylphorbol Acetate	96-99	interleukin 2	Mus musculus	224-237
3918270-6	1985	However, either one in combination with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), which is structurally related to 1,2-diacylglycerol, induces in lymphoid cell populations the expression of receptors for interleukin-2 (IL-2), the secretion of IL-2 and cell proliferation as measured by 3H-thymidine uptake.	Tetradecanoylphorbol Acetate	96-99	interleukin 2	Mus musculus	239-243
3918270-6	1985	However, either one in combination with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), which is structurally related to 1,2-diacylglycerol, induces in lymphoid cell populations the expression of receptors for interleukin-2 (IL-2), the secretion of IL-2 and cell proliferation as measured by 3H-thymidine uptake.	Tetradecanoylphorbol Acetate	96-99	interleukin 2	Mus musculus	263-267
3365842-1	1988	Hyperplasiogenic and tumor-promoting phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate or 12-O-retinoylphorbol-13-acetate induce the sequential transient expression of the proto-oncogenes c-fos and c-myc and the ornithine decarboxylase gene in mouse skin in vivo.	Tetradecanoylphorbol Acetate	60-96	FBJ osteosarcoma oncogene	Mus musculus	198-203
1333046-7	1992	The phosphorylation of Nck was also enhanced following treatment of A431 cells with phorbol 12-myristate 13-acetate or forskolin.	Tetradecanoylphorbol Acetate	84-115	NCK adaptor protein 1	Homo sapiens	23-26
1429660-4	1992	Cytosolic S6 kinase activity was stimulated by stretch/relaxation, angiotensin II, epidermal growth factor, or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	111-142	ribosomal protein S6 kinase B1	Rattus norvegicus	10-19
3130394-3	1988	Treatment of HuVEC with interleukin 1, tumor necrosis factor (TNF), bacterial endotoxin, and 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in time and dose-dependent increases of adhesiveness for basophils.	Tetradecanoylphorbol Acetate	93-129	interleukin 1 alpha	Homo sapiens	24-60
3130394-3	1988	Treatment of HuVEC with interleukin 1, tumor necrosis factor (TNF), bacterial endotoxin, and 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in time and dose-dependent increases of adhesiveness for basophils.	Tetradecanoylphorbol Acetate	131-134	interleukin 1 alpha	Homo sapiens	24-60
3967339-2	1985	The addition of 10(-8) M 12-O-tetradecanoylphorbol-13-acetate (TPA) to promotable clones caused a 2-fold enhancement of the FN release over solvent control.	Tetradecanoylphorbol Acetate	25-61	fibronectin 1	Mus musculus	124-126
3967339-2	1985	The addition of 10(-8) M 12-O-tetradecanoylphorbol-13-acetate (TPA) to promotable clones caused a 2-fold enhancement of the FN release over solvent control.	Tetradecanoylphorbol Acetate	63-66	fibronectin 1	Mus musculus	124-126
3967339-5	1985	The vitamin A derivative retinoic acid (RA) antagonized the TPA-caused FN-release in promotable clones.	Tetradecanoylphorbol Acetate	60-63	fibronectin 1	Mus musculus	71-73
3260332-0	1988	Independent transcriptional regulation of a single VL30 element by epidermal growth factor and activators of protein kinase C. A single VL30 element present in the RVL-3 cell line was transcriptionally induced by both epidermal growth factor (EGF) and the protein kinase C (pkC) activators 12-O-tetradecanoylphorbol-13-acetate (TPA) and sn-1,2-dioctanoylglycerol within 5 min of stimulation.	Tetradecanoylphorbol Acetate	290-326	epidermal growth factor	Homo sapiens	67-90
1429660-5	1992	The increased S6 kinase activity was detectable within 30 min after initiation of stretch/relaxation and was blocked by either inhibitors of protein kinase C or prior down-regulation of protein kinase C following prolonged incubation with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	239-270	ribosomal protein S6 kinase B1	Rattus norvegicus	14-23
3260332-0	1988	Independent transcriptional regulation of a single VL30 element by epidermal growth factor and activators of protein kinase C. A single VL30 element present in the RVL-3 cell line was transcriptionally induced by both epidermal growth factor (EGF) and the protein kinase C (pkC) activators 12-O-tetradecanoylphorbol-13-acetate (TPA) and sn-1,2-dioctanoylglycerol within 5 min of stimulation.	Tetradecanoylphorbol Acetate	290-326	epidermal growth factor	Homo sapiens	218-241
1385152-6	1992	CD5+ B cells could be stimulated for DNA synthesis by mitogenic concentrations of Staphylococcus aureus, Cowan I strain (SAC), insolubilized anti-IgM antibodies, immobilized anti-CD40 antibodies and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	199-230	CD5 molecule	Homo sapiens	0-3
3260332-0	1988	Independent transcriptional regulation of a single VL30 element by epidermal growth factor and activators of protein kinase C. A single VL30 element present in the RVL-3 cell line was transcriptionally induced by both epidermal growth factor (EGF) and the protein kinase C (pkC) activators 12-O-tetradecanoylphorbol-13-acetate (TPA) and sn-1,2-dioctanoylglycerol within 5 min of stimulation.	Tetradecanoylphorbol Acetate	290-326	epidermal growth factor	Homo sapiens	243-246
3260332-0	1988	Independent transcriptional regulation of a single VL30 element by epidermal growth factor and activators of protein kinase C. A single VL30 element present in the RVL-3 cell line was transcriptionally induced by both epidermal growth factor (EGF) and the protein kinase C (pkC) activators 12-O-tetradecanoylphorbol-13-acetate (TPA) and sn-1,2-dioctanoylglycerol within 5 min of stimulation.	Tetradecanoylphorbol Acetate	328-331	epidermal growth factor	Homo sapiens	67-90
3260332-0	1988	Independent transcriptional regulation of a single VL30 element by epidermal growth factor and activators of protein kinase C. A single VL30 element present in the RVL-3 cell line was transcriptionally induced by both epidermal growth factor (EGF) and the protein kinase C (pkC) activators 12-O-tetradecanoylphorbol-13-acetate (TPA) and sn-1,2-dioctanoylglycerol within 5 min of stimulation.	Tetradecanoylphorbol Acetate	328-331	epidermal growth factor	Homo sapiens	218-241
3260332-0	1988	Independent transcriptional regulation of a single VL30 element by epidermal growth factor and activators of protein kinase C. A single VL30 element present in the RVL-3 cell line was transcriptionally induced by both epidermal growth factor (EGF) and the protein kinase C (pkC) activators 12-O-tetradecanoylphorbol-13-acetate (TPA) and sn-1,2-dioctanoylglycerol within 5 min of stimulation.	Tetradecanoylphorbol Acetate	328-331	epidermal growth factor	Homo sapiens	243-246
3863149-6	1985	We found that TPA treatment leads to a de novo induction of two cytoskeletal proteins, vimentin and actin.	Tetradecanoylphorbol Acetate	14-17	vimentin	Homo sapiens	87-95
6441115-10	1984	Murine thymocytes incubated with PMA for 30 min or with ConA for 4 hr (mitogen-pulsed T-cells) failed to bind the anti-IL-2 receptor antibody AMT-13 and to absorb IL-2 activity present in semipurified IL-2 preparations, but they proliferated vigorously in response to the same IL-2 preparations.	Tetradecanoylphorbol Acetate	33-36	interleukin 2	Mus musculus	119-123
6441115-10	1984	Murine thymocytes incubated with PMA for 30 min or with ConA for 4 hr (mitogen-pulsed T-cells) failed to bind the anti-IL-2 receptor antibody AMT-13 and to absorb IL-2 activity present in semipurified IL-2 preparations, but they proliferated vigorously in response to the same IL-2 preparations.	Tetradecanoylphorbol Acetate	33-36	interleukin 2	Mus musculus	163-167
6441115-10	1984	Murine thymocytes incubated with PMA for 30 min or with ConA for 4 hr (mitogen-pulsed T-cells) failed to bind the anti-IL-2 receptor antibody AMT-13 and to absorb IL-2 activity present in semipurified IL-2 preparations, but they proliferated vigorously in response to the same IL-2 preparations.	Tetradecanoylphorbol Acetate	33-36	interleukin 2	Mus musculus	163-167
1385152-6	1992	CD5+ B cells could be stimulated for DNA synthesis by mitogenic concentrations of Staphylococcus aureus, Cowan I strain (SAC), insolubilized anti-IgM antibodies, immobilized anti-CD40 antibodies and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	232-235	CD5 molecule	Homo sapiens	0-3
20732162-3	1992	The tumour-promoting phorbol ester 12-O-tetradecanoyl-13-acetate (TPA) induced ODC by several hundred percent in this system.	Tetradecanoylphorbol Acetate	66-69	ornithine decarboxylase 1	Rattus norvegicus	79-82
6208480-10	1984	Treatment of cells with TPA before addition of EGF inhibited all three of these EGF-dependent responses.	Tetradecanoylphorbol Acetate	24-27	epidermal growth factor	Homo sapiens	80-83
1400509-5	1992	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) led to significant but transient enhancement of the incorporation of [32P]orthophosphate into Rex protein.	Tetradecanoylphorbol Acetate	24-60	p27	Human T-cell leukemia virus type I	161-164
6436129-2	1984	Both TPA and teleocidin B caused a marked increase in the synthesis of two polypeptides with molecular weights of 44 kilodaltons (p44) and 55 kilodaltons (p55).	Tetradecanoylphorbol Acetate	5-8	H3 histone pseudogene 44	Homo sapiens	155-158
3041347-0	1988	Post-translational alterations of the tyrosine kinase p56lck in response to activators of protein kinase C. We have found in different human cells of lymphoid and non-lymphoid origin that the 56 kilodalton (kDa) lck protein is rapidly converted to a product migrating at approximately 60 kDa (designated p60lck) in response to the phorbol ester 4 alpha-phorbol 12 beta-myristate (PMA) as well as the diacylglycerol analogue 1,2-dioctanoyl-sn-glycerol (diC8).	Tetradecanoylphorbol Acetate	380-383	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	54-60
3041347-0	1988	Post-translational alterations of the tyrosine kinase p56lck in response to activators of protein kinase C. We have found in different human cells of lymphoid and non-lymphoid origin that the 56 kilodalton (kDa) lck protein is rapidly converted to a product migrating at approximately 60 kDa (designated p60lck) in response to the phorbol ester 4 alpha-phorbol 12 beta-myristate (PMA) as well as the diacylglycerol analogue 1,2-dioctanoyl-sn-glycerol (diC8).	Tetradecanoylphorbol Acetate	380-383	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	57-60
1400509-5	1992	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) led to significant but transient enhancement of the incorporation of [32P]orthophosphate into Rex protein.	Tetradecanoylphorbol Acetate	62-65	p27	Human T-cell leukemia virus type I	161-164
1400509-6	1992	N-terminal truncation of Rex protein abolished TPA-dependent phosphorylation.	Tetradecanoylphorbol Acetate	47-50	p27	Human T-cell leukemia virus type I	25-28
3345591-4	1988	With TPA present, accumulation of 32P-labeled FN at the cell layer of HLF was much slower than under control conditions.	Tetradecanoylphorbol Acetate	5-8	HLF transcription factor, PAR bZIP family member	Homo sapiens	70-73
1417981-8	1992	Taken together, these findings suggest that the activated glucocorticoid receptor inhibits signaling pathways which include expression of the EGR-1 and NF-kappa B genes and that such effects may contribute to a block in TPA-induced monocytic differentiation.	Tetradecanoylphorbol Acetate	220-223	early growth response 1	Homo sapiens	142-147
3345591-7	1988	We investigated the ability of FN from normal and TPA-treated cells to bind to normal HLF monolayers.	Tetradecanoylphorbol Acetate	50-53	HLF transcription factor, PAR bZIP family member	Homo sapiens	86-89
6611555-9	1984	IL-2 production by the patient"s phytohemagglutin-stimulated PBMC was severely deficient but was corrected by the addition of phorbol 12-myristate 13-acetate, suggesting a defective response to IL-1.	Tetradecanoylphorbol Acetate	126-157	interleukin 1 alpha	Homo sapiens	194-198
1394183-4	1992	After an acute exposure to tetradecanoyl-13-phorbol acetate (TPA), PKC-epsilon translocated to the particulate fraction.	Tetradecanoylphorbol Acetate	61-64	protein kinase C epsilon	Homo sapiens	67-78
6330113-1	1984	4 beta-Phorbol 12 beta-myristate 13 alpha-acetate (PMA) markedly inhibited the binding of low concentrations (less than 10(-9 m) of 125I-epidermal growth factor (EGF) to A431 human epidermoid carcinoma cells.	Tetradecanoylphorbol Acetate	51-54	epidermal growth factor	Homo sapiens	132-160
1394183-6	1992	Longer exposures to TPA decreased PKC-epsilon in both cellular fractions.	Tetradecanoylphorbol Acetate	20-23	protein kinase C epsilon	Homo sapiens	34-45
6330113-1	1984	4 beta-Phorbol 12 beta-myristate 13 alpha-acetate (PMA) markedly inhibited the binding of low concentrations (less than 10(-9 m) of 125I-epidermal growth factor (EGF) to A431 human epidermoid carcinoma cells.	Tetradecanoylphorbol Acetate	51-54	epidermal growth factor	Homo sapiens	162-165
2449430-3	1988	Treatment of quiescent cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA) to down-regulate protein kinase C inhibited TPA-stimulated c-myc expression but did not affect the PDGF-modulated process.	Tetradecanoylphorbol Acetate	34-71	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	137-142
1394183-7	1992	PKC-epsilon displayed a similar sensitivity to TPA-induced down-regulation as did PKC-beta while PKC-alpha was more resistant to this effect.	Tetradecanoylphorbol Acetate	47-50	protein kinase C epsilon	Homo sapiens	0-11
2449430-3	1988	Treatment of quiescent cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA) to down-regulate protein kinase C inhibited TPA-stimulated c-myc expression but did not affect the PDGF-modulated process.	Tetradecanoylphorbol Acetate	73-76	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	137-142
2449430-3	1988	Treatment of quiescent cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA) to down-regulate protein kinase C inhibited TPA-stimulated c-myc expression but did not affect the PDGF-modulated process.	Tetradecanoylphorbol Acetate	122-125	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	137-142
6330113-4	1984	In order to examine this action of PMA on the EGF receptor, the receptor phosphorylation state was evaluated in A431 cells that had been incubated with [32P]phosphate for 3 h prior to the addition of PMA.	Tetradecanoylphorbol Acetate	35-38	epidermal growth factor	Homo sapiens	46-49
1394183-8	1992	After a 72-h exposure to 0.1 nM TPA, increases in the alpha and beta isoforms but not in PKC-epsilon were observed.	Tetradecanoylphorbol Acetate	32-35	protein kinase C epsilon	Homo sapiens	89-100
6744241-4	1984	With anthralin a slow decrease of ODC back to control level is observed approximately within 22 h. In contrast, ODC induction mediated by other tumor promoters like TPA and PB decreased to control levels within 4-6 hours.	Tetradecanoylphorbol Acetate	165-168	ornithine decarboxylase 1	Rattus norvegicus	112-115
1408831-1	1992	Glutathione Transferase P (GST-P) gene expression is dominantly regulated by an upstream enhancer (GPEI) consisting of a dyad of palindromically oriented imperfect TPA (12-O-tetradecanoyl-phorbol-13-acetate)-responsive elements (TRE).	Tetradecanoylphorbol Acetate	164-167	glutathione S-transferase pi 1	Homo sapiens	27-32
6325057-2	1984	The addition of bacterial lipopolysaccharides (LPS), quartz silica particles, zymosan, or phorbol myristate acetate (PMA) enhanced 3 to 50 times the overall production and 25 to 2000 times the release of IL-1.	Tetradecanoylphorbol Acetate	90-115	interleukin 1 alpha	Homo sapiens	204-208
1408831-1	1992	Glutathione Transferase P (GST-P) gene expression is dominantly regulated by an upstream enhancer (GPEI) consisting of a dyad of palindromically oriented imperfect TPA (12-O-tetradecanoyl-phorbol-13-acetate)-responsive elements (TRE).	Tetradecanoylphorbol Acetate	169-206	glutathione S-transferase pi 1	Homo sapiens	27-32
6325057-2	1984	The addition of bacterial lipopolysaccharides (LPS), quartz silica particles, zymosan, or phorbol myristate acetate (PMA) enhanced 3 to 50 times the overall production and 25 to 2000 times the release of IL-1.	Tetradecanoylphorbol Acetate	117-120	interleukin 1 alpha	Homo sapiens	204-208
1280321-3	1992	However, we have demonstrated a significant 32P incorporation in the ANF-R1 receptor of the TPA-treated cells.	Tetradecanoylphorbol Acetate	92-95	natriuretic peptide A	Bos taurus	69-72
6607119-5	1984	Similarly, after treatment of 3T3 cells with the tumor-promoter phorbol myristate acetate, which induces a transformation-like phenotype, the cells no longer respond to PDGF as a chemoattractant but retain their migratory response to fibronectin.	Tetradecanoylphorbol Acetate	64-89	fibronectin 1	Mus musculus	234-245
1280321-4	1992	The effect of TPA on the zona glomerulosa ANF-R1 receptors was abolished by calphostin C, a specific protein kinase C inhibitor.	Tetradecanoylphorbol Acetate	14-17	natriuretic peptide A	Bos taurus	42-45
6607129-5	1984	In this study, TH2.52, a subclone of B-cell hybridomas between M12.4.1 B lymphoma of BALB/c mice and normal B cells of C57BL/6 (B6) mice was treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) and the differentiative effect of TPA was examined.	Tetradecanoylphorbol Acetate	154-190	heart and neural crest derivatives expressed 2	Mus musculus	15-18
6607129-6	1984	TPA treatment inhibited the spontaneous proliferation of TH2.52 and induced significant IgM secretion by the hybrid.	Tetradecanoylphorbol Acetate	0-3	heart and neural crest derivatives expressed 2	Mus musculus	57-60
6607129-9	1984	In addition, the differentiative response of TH2.52 to TPA was completely blocked by retinoic acid (RA).	Tetradecanoylphorbol Acetate	55-58	heart and neural crest derivatives expressed 2	Mus musculus	45-48
11537644-4	1992	In addition, we have investigated signalling pathways as induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), forskolin, and A23187 that bypass the EGF receptor, but mimic the partial activation of signal transduction pathways.	Tetradecanoylphorbol Acetate	68-104	epidermal growth factor	Homo sapiens	150-153
6607129-10	1984	Moreover, TH2.52 cells treated with TPA were demonstrated to decrease the expression of Iab, Iad molecules as well as IgM molecules on the cell membrane by analyses of flow microfluorometry (FMF) and quantitative absorption tests.	Tetradecanoylphorbol Acetate	36-39	heart and neural crest derivatives expressed 2	Mus musculus	10-13
6607129-12	1984	The result clearly demonstrates that TH2.52 cells can be induced to differentiate into IgM-secreting cells after treatment with TPA, followed by the decrease in the expression of B-cell surface antigens on the cell membrane.	Tetradecanoylphorbol Acetate	128-131	heart and neural crest derivatives expressed 2	Mus musculus	37-40
1394140-6	1992	The effect of CGP 41251 was reversible, since its removal led to a normal expression of c-fos mRNA in response to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	114-145	FBJ osteosarcoma oncogene	Mus musculus	88-93
6724225-5	1984	TPA showed more potent induction of ODC activity than deoxycholate, although the maximal induction was greater in the case of deoxycholate treatment.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase 1	Rattus norvegicus	36-39
1395096-4	1992	Sequential immunoprecipitation studies with the MoAb 44G4, which recognizes the O- and N-glycosylated homodimer endoglin, showed that both MoAbs recognize the same molecule on HUVE and phorbol myristate acetate (PMA)-stimulated U937 cells.	Tetradecanoylphorbol Acetate	185-210	endoglin	Homo sapiens	112-120
6335128-0	1984	Interleukin 2-dependent T cell line acquires responsiveness to phorbol myristate acetate and lipopolysaccharide in the course of long-term culture.	Tetradecanoylphorbol Acetate	63-88	interleukin 2	Mus musculus	0-13
1445798-2	1992	We previously found that a chloramphenicol acetyltransferase reporter gene driven by the collagenase TPA responsive element was expressed upon stimulation of T-cells by TPA and that this expression was enhanced when IL-1 was added as a costimulant; IL-1 alone had no effect on TPA responsive element-chloramphenicol acetyltransferase expression.	Tetradecanoylphorbol Acetate	101-104	interleukin 1 alpha	Homo sapiens	216-220
6335128-1	1984	We have observed that CT6 cell line, a murine interleukin 2 (IL 2)-dependent T cell line, was highly responsive to phorbol myristate acetate (PMA) and to a lesser extent but significantly responsive to lipopolysaccharide (LPS) in the short-term proliferation assay.	Tetradecanoylphorbol Acetate	115-140	interleukin 2	Mus musculus	46-59
6335128-1	1984	We have observed that CT6 cell line, a murine interleukin 2 (IL 2)-dependent T cell line, was highly responsive to phorbol myristate acetate (PMA) and to a lesser extent but significantly responsive to lipopolysaccharide (LPS) in the short-term proliferation assay.	Tetradecanoylphorbol Acetate	115-140	interleukin 2	Mus musculus	61-65
1445798-2	1992	We previously found that a chloramphenicol acetyltransferase reporter gene driven by the collagenase TPA responsive element was expressed upon stimulation of T-cells by TPA and that this expression was enhanced when IL-1 was added as a costimulant; IL-1 alone had no effect on TPA responsive element-chloramphenicol acetyltransferase expression.	Tetradecanoylphorbol Acetate	101-104	interleukin 1 alpha	Homo sapiens	249-253
6335128-1	1984	We have observed that CT6 cell line, a murine interleukin 2 (IL 2)-dependent T cell line, was highly responsive to phorbol myristate acetate (PMA) and to a lesser extent but significantly responsive to lipopolysaccharide (LPS) in the short-term proliferation assay.	Tetradecanoylphorbol Acetate	142-145	interleukin 2	Mus musculus	46-59
6335128-1	1984	We have observed that CT6 cell line, a murine interleukin 2 (IL 2)-dependent T cell line, was highly responsive to phorbol myristate acetate (PMA) and to a lesser extent but significantly responsive to lipopolysaccharide (LPS) in the short-term proliferation assay.	Tetradecanoylphorbol Acetate	142-145	interleukin 2	Mus musculus	61-65
1445798-2	1992	We previously found that a chloramphenicol acetyltransferase reporter gene driven by the collagenase TPA responsive element was expressed upon stimulation of T-cells by TPA and that this expression was enhanced when IL-1 was added as a costimulant; IL-1 alone had no effect on TPA responsive element-chloramphenicol acetyltransferase expression.	Tetradecanoylphorbol Acetate	169-172	interleukin 1 alpha	Homo sapiens	216-220
6334241-0	1984	Phorbol myristate acetate-stimulated production of interleukin 2 by T-cell lymphoma and constitutive production by derived hybridomas.	Tetradecanoylphorbol Acetate	0-25	interleukin 2	Mus musculus	51-64
1445798-2	1992	We previously found that a chloramphenicol acetyltransferase reporter gene driven by the collagenase TPA responsive element was expressed upon stimulation of T-cells by TPA and that this expression was enhanced when IL-1 was added as a costimulant; IL-1 alone had no effect on TPA responsive element-chloramphenicol acetyltransferase expression.	Tetradecanoylphorbol Acetate	169-172	interleukin 1 alpha	Homo sapiens	249-253
1445798-2	1992	We previously found that a chloramphenicol acetyltransferase reporter gene driven by the collagenase TPA responsive element was expressed upon stimulation of T-cells by TPA and that this expression was enhanced when IL-1 was added as a costimulant; IL-1 alone had no effect on TPA responsive element-chloramphenicol acetyltransferase expression.	Tetradecanoylphorbol Acetate	169-172	interleukin 1 alpha	Homo sapiens	216-220
1445798-2	1992	We previously found that a chloramphenicol acetyltransferase reporter gene driven by the collagenase TPA responsive element was expressed upon stimulation of T-cells by TPA and that this expression was enhanced when IL-1 was added as a costimulant; IL-1 alone had no effect on TPA responsive element-chloramphenicol acetyltransferase expression.	Tetradecanoylphorbol Acetate	169-172	interleukin 1 alpha	Homo sapiens	249-253
6689054-4	1983	We now report that TPA-induced activation of platelets is associated with the phosphorylation of the 20,000-MW light chain of myosin, that it appears to be mediated mainly through protein kinase C and that the site phosphorylated in the myosin light chain is distinct from that phosphorylated by myosin light chain kinase.	Tetradecanoylphorbol Acetate	19-22	myosin heavy chain 14	Homo sapiens	126-132
6689054-4	1983	We now report that TPA-induced activation of platelets is associated with the phosphorylation of the 20,000-MW light chain of myosin, that it appears to be mediated mainly through protein kinase C and that the site phosphorylated in the myosin light chain is distinct from that phosphorylated by myosin light chain kinase.	Tetradecanoylphorbol Acetate	19-22	myosin heavy chain 14	Homo sapiens	237-243
1445798-5	1992	Although the levels of other fos-related mRNAs were also elevated, their maximal induction was delayed by approximately 5 h. IL-1 alone had little or no effect, but enhanced TPA induced transcription and steady-state levels of these mRNAs.	Tetradecanoylphorbol Acetate	174-177	interleukin 1 alpha	Homo sapiens	125-129
6689054-4	1983	We now report that TPA-induced activation of platelets is associated with the phosphorylation of the 20,000-MW light chain of myosin, that it appears to be mediated mainly through protein kinase C and that the site phosphorylated in the myosin light chain is distinct from that phosphorylated by myosin light chain kinase.	Tetradecanoylphorbol Acetate	19-22	myosin heavy chain 14	Homo sapiens	237-243
1445798-7	1992	These findings indicate that the synergistic effect of IL-1 and TPA on AP-1 mediated gene expression is due, in part, to the ability of IL-1 to enhance the expression of genes encoding specific AP-1 transcription factor components.	Tetradecanoylphorbol Acetate	64-67	interleukin 1 alpha	Homo sapiens	136-140
1396338-14	1992	When astrocytes were exposed to IGF-I (10 nM) and TPA (10 nM) in combination, [3H]thymidine uptake was significantly higher than the uptake induced by either IGF-I (10 nM) or TPA (10 nM) alone.	Tetradecanoylphorbol Acetate	50-53	insulin-like growth factor 1	Rattus norvegicus	158-163
6605305-5	1983	On the other hand the non-physiological phorbol ester, 12-O-tetradecanoyl phorbol acetate (TPA), a tumour promotor with potency of inducing differentiation in some leukaemic cell lines, induced changes in both normal thymocytes and in the leukaemic line JM1 were inconsistent with maturation, e.g. a fall in the percentage of OKT3 cells.	Tetradecanoylphorbol Acetate	55-89	coiled-coil domain containing 22	Homo sapiens	254-257
6605305-5	1983	On the other hand the non-physiological phorbol ester, 12-O-tetradecanoyl phorbol acetate (TPA), a tumour promotor with potency of inducing differentiation in some leukaemic cell lines, induced changes in both normal thymocytes and in the leukaemic line JM1 were inconsistent with maturation, e.g. a fall in the percentage of OKT3 cells.	Tetradecanoylphorbol Acetate	91-94	coiled-coil domain containing 22	Homo sapiens	254-257
1396338-14	1992	When astrocytes were exposed to IGF-I (10 nM) and TPA (10 nM) in combination, [3H]thymidine uptake was significantly higher than the uptake induced by either IGF-I (10 nM) or TPA (10 nM) alone.	Tetradecanoylphorbol Acetate	175-178	insulin-like growth factor 1	Rattus norvegicus	32-37
1396338-16	1992	In a second experiment, the mitogenic effect of IGF-I was partially abolished in cells depleted of PKC by preincubation with high concentrations of TPA (300 nM).	Tetradecanoylphorbol Acetate	148-151	insulin-like growth factor 1	Rattus norvegicus	48-53
1338103-11	1992	Stimulation of the exchanger under isosmotic conditions by 25 nM 4 beta-phorbol 12-myristate 13-acetate (PMA) and 0.1 mM vanadate resulted in an amiloride-sensitive pHi increase of about 0.08 pH units.	Tetradecanoylphorbol Acetate	65-103	glucose-6-phosphate isomerase	Rattus norvegicus	165-168
6578872-5	1983	Cultured leukemia cells and the TPA-derived macrophage only incorporated from 16% to 23% of the total radioactivity into the C-1 position, indicating an operable de novo pathway.	Tetradecanoylphorbol Acetate	32-35	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	125-128
1338103-11	1992	Stimulation of the exchanger under isosmotic conditions by 25 nM 4 beta-phorbol 12-myristate 13-acetate (PMA) and 0.1 mM vanadate resulted in an amiloride-sensitive pHi increase of about 0.08 pH units.	Tetradecanoylphorbol Acetate	105-108	glucose-6-phosphate isomerase	Rattus norvegicus	165-168
1399115-2	1992	We show that TPA initiates this phenomenon by promoting a calpain-dependent conversion of PKC to the Ca2+ phospholipid-independent protein kinase M (PKM), at physiological calcium concentrations.	Tetradecanoylphorbol Acetate	13-16	pyruvate kinase M1/2	Homo sapiens	149-152
6311852-0	1983	Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the growth inhibitory and increased phosphatidylinositol (PI) responses induced by epidermal growth factor (EGF) in A431 cells.	Tetradecanoylphorbol Acetate	10-46	epidermal growth factor	Homo sapiens	139-162
6311852-0	1983	Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the growth inhibitory and increased phosphatidylinositol (PI) responses induced by epidermal growth factor (EGF) in A431 cells.	Tetradecanoylphorbol Acetate	10-46	epidermal growth factor	Homo sapiens	164-167
6311852-0	1983	Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the growth inhibitory and increased phosphatidylinositol (PI) responses induced by epidermal growth factor (EGF) in A431 cells.	Tetradecanoylphorbol Acetate	48-51	epidermal growth factor	Homo sapiens	139-162
6311852-0	1983	Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the growth inhibitory and increased phosphatidylinositol (PI) responses induced by epidermal growth factor (EGF) in A431 cells.	Tetradecanoylphorbol Acetate	48-51	epidermal growth factor	Homo sapiens	164-167
1399115-4	1992	Moreover, PKM generated from the calpain-PKC complex was resistant to calpain, even after addition of TPA.	Tetradecanoylphorbol Acetate	102-105	pyruvate kinase M1/2	Homo sapiens	10-13
1527065-8	1992	In addition, it was found that growth factors, including epidermal growth factor, insulin, and insulin-like growth factor-I, and a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), can also activate Ras under the same conditions.	Tetradecanoylphorbol Acetate	185-188	insulin-like growth factor 1	Rattus norvegicus	57-123
6604035-4	1983	Upon induction of proliferation of these cells by short-term culture in the presence of phytohemagglutinin (PHA) and 12-O-tetradecanoyl phorbol-13-acetate (TPA), an increase from 1% to 28% HTLV p19+ cells was observed confirming previous findings that HTLV p19 expression was correlated with proliferative activity of the host cells.	Tetradecanoylphorbol Acetate	117-154	interleukin 23 subunit alpha	Homo sapiens	194-197
6408170-12	1983	Our results indicate that TPA mimics IL 1 in the induction of differentiation of the ST to a stage in which subpopulations of these cells are able to produce IL 2 and to respond to PHA.	Tetradecanoylphorbol Acetate	26-29	interleukin 2	Mus musculus	158-162
6304119-7	1983	Thus, TPA is able to mimic CSF-1 in its effects on CSF-1 responsive cells in some aspects (the spectrum of target cells, the morphology of resulting colonies, and the ability to down-regulate the CSF-1 receptor) but it is not able to mimic CSF-1 in other ways (TPA alone cannot stimulate the full CSF-1 response, TPA does not stimulate the most primitive CSF-1 responsive cells, and TPA does not bind to the CSF-1 receptor).	Tetradecanoylphorbol Acetate	6-9	colony stimulating factor 1 receptor	Mus musculus	196-210
6304119-7	1983	Thus, TPA is able to mimic CSF-1 in its effects on CSF-1 responsive cells in some aspects (the spectrum of target cells, the morphology of resulting colonies, and the ability to down-regulate the CSF-1 receptor) but it is not able to mimic CSF-1 in other ways (TPA alone cannot stimulate the full CSF-1 response, TPA does not stimulate the most primitive CSF-1 responsive cells, and TPA does not bind to the CSF-1 receptor).	Tetradecanoylphorbol Acetate	6-9	colony stimulating factor 1 receptor	Mus musculus	408-422
6302699-6	1983	A potent tumor promoter, 12-O-tetradecanoylphorbol 13-acetate, acted synergistically with EGF in terms of stimulation of DNA synthesis but not in terms of inhibition of casein synthesis when the two agents were added at a suboptimal concentration.	Tetradecanoylphorbol Acetate	25-61	epidermal growth factor	Mus musculus	90-93
6188625-1	1983	The response of a human embryonal carcinoma cell line LICR LON HT39/7 to 12-O-tetradecanylphorbol 13-acetate (TPA) has been studied.	Tetradecanoylphorbol Acetate	110-113	lon peptidase 1, mitochondrial	Homo sapiens	59-62
6188625-7	1983	The high levels of alkaline phosphatase normally present in LICR LON HT39/7 are also reduced by TPA.	Tetradecanoylphorbol Acetate	96-99	lon peptidase 1, mitochondrial	Homo sapiens	65-68
6188625-10	1983	2-Dimensional gel electrophoresis of the proteins synthesized by LICR LON HT39/7 before and after addition of TPA has shown that there are a number of alterations in the proteins synthesised by the treated cells.	Tetradecanoylphorbol Acetate	110-113	lon peptidase 1, mitochondrial	Homo sapiens	70-73
6188625-12	1983	The alterations in the phenotype of LICR LON HT39/7 induced by TPA are irreversible and the altered cells, whilst they stop dividing, can be maintained for at least three weeks in culture.	Tetradecanoylphorbol Acetate	63-66	lon peptidase 1, mitochondrial	Homo sapiens	41-44
6600707-5	1983	The antibody, obtained from hybridomas derived from mice immunized with phorbol-myristate-acetate-pulsed rat T lymphoblasts, exhibited species specificity, indicating that IL-2 receptors of various species are not necessarily identical, even if they can respond to IL-2 from different species.	Tetradecanoylphorbol Acetate	72-97	interleukin 2	Rattus norvegicus	172-176
6600707-5	1983	The antibody, obtained from hybridomas derived from mice immunized with phorbol-myristate-acetate-pulsed rat T lymphoblasts, exhibited species specificity, indicating that IL-2 receptors of various species are not necessarily identical, even if they can respond to IL-2 from different species.	Tetradecanoylphorbol Acetate	72-97	interleukin 2	Rattus norvegicus	265-269
6848192-4	1983	dose of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 micrograms/kg) enhanced the activity of ODC about 70-fold within 12 hr in C57BL/6 mice and 18-fold within 24 hr in DBA/2 mice without affecting AHH activity markedly.	Tetradecanoylphorbol Acetate	27-63	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	218-221
6848192-4	1983	dose of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 micrograms/kg) enhanced the activity of ODC about 70-fold within 12 hr in C57BL/6 mice and 18-fold within 24 hr in DBA/2 mice without affecting AHH activity markedly.	Tetradecanoylphorbol Acetate	65-68	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	218-221
6400065-5	1983	Erythrodifferentiation of HGPRT negative Friend murine leukemia cells by 6-thioguanine was antagonized by tetracaine, d, 1-propranolol and 12-O-tetradecanoylphorbol-13-acetate, providing evidence for a cell membrane mediated component in the action of the purine antimetabolite.	Tetradecanoylphorbol Acetate	139-175	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	26-31
6978745-7	1982	Particularly, such effects of TPA on KLM-2 cells were markedly accelerated in the presence of CSF.	Tetradecanoylphorbol Acetate	30-33	colony stimulating factor 2	Homo sapiens	94-97
7046911-6	1982	We have demonstrated that ACR cells can be differentially transformed by oncogenic viruses, a carcinogen (MNNG), and gamma-ray irradiation, and that they can proliferate in vitro after exposure to a tumor promoter (TPA.	Tetradecanoylphorbol Acetate	215-218	acrosin	Homo sapiens	26-29
6801122-5	1982	The phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), has been shown to have IL 1-like effects in other species and is a polyclonal activator of human T and B lymphocytes.	Tetradecanoylphorbol Acetate	19-56	interleukin 1 alpha	Homo sapiens	87-91
6801122-5	1982	The phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), has been shown to have IL 1-like effects in other species and is a polyclonal activator of human T and B lymphocytes.	Tetradecanoylphorbol Acetate	58-61	interleukin 1 alpha	Homo sapiens	87-91
6801122-8	1982	Thus, TPA appears to mimic the macrophage-replacing ability of soluble factors (IL 1, macrophage supernatants) in the triggering of human lymphocytes.	Tetradecanoylphorbol Acetate	6-9	interleukin 1 alpha	Homo sapiens	80-84
7066921-3	1982	The phenotypic profile of ACR cells chronically exposed to TPA, although effecting a change toward a more transformed phenotype (e.g., growth in agar), was in large measure neither stable nor uniform during consecutive passages or for a given cell strain during different periods of TPA application.	Tetradecanoylphorbol Acetate	59-62	acrosin	Homo sapiens	26-29
7066921-3	1982	The phenotypic profile of ACR cells chronically exposed to TPA, although effecting a change toward a more transformed phenotype (e.g., growth in agar), was in large measure neither stable nor uniform during consecutive passages or for a given cell strain during different periods of TPA application.	Tetradecanoylphorbol Acetate	283-286	acrosin	Homo sapiens	26-29
7066921-5	1982	We speculated that TPA-induced aneuploidy in these cells, coupled with DNA instability and aberrant chromosomal segregation, may conceivably be consistent with neoplasia in initiated ACR cells.	Tetradecanoylphorbol Acetate	19-22	acrosin	Homo sapiens	183-186
7066921-6	1982	Finally, the apparent susceptibility of ACR cells to further transformation by TPA and N-methyl-N1-nitro-N-nitrosoguanidine (MNNG) (34,48) and by ocongenic viruses (37,45) indicates that genetic information residing within these cells, probably in the form of an ACR mutation, renders them more sensitive to these two distinct classes of carcinogens.	Tetradecanoylphorbol Acetate	79-82	acrosin	Homo sapiens	40-43
7278734-8	1981	Possible receptor sites for TPA are reviewed to include a hypothetical external membrane receptor, PLA2, pro- PLA2, and PLC, as well as the possible nature of the endogenous ligand at the "TPA receptor" to include a phospholipid and a polypeptide.	Tetradecanoylphorbol Acetate	28-31	heparan sulfate proteoglycan 2	Homo sapiens	120-123
7007026-4	1981	However, hormone secretion declined rapidly, reaching basal levels within 12 h. Both the calcium ionophore A23187 and the cocarcinogen phorbol myristate acetate were effective in releasing additional LH and FSH from cells made refractory to 30 nM GnRH, whereas higher doses of GnRH and 8-bromo-cAMP were minimally active.	Tetradecanoylphorbol Acetate	135-160	gonadotropin releasing hormone 1	Rattus norvegicus	247-251
7007026-4	1981	However, hormone secretion declined rapidly, reaching basal levels within 12 h. Both the calcium ionophore A23187 and the cocarcinogen phorbol myristate acetate were effective in releasing additional LH and FSH from cells made refractory to 30 nM GnRH, whereas higher doses of GnRH and 8-bromo-cAMP were minimally active.	Tetradecanoylphorbol Acetate	135-160	gonadotropin releasing hormone 1	Rattus norvegicus	277-281
7194349-1	1981	Tumor-promoting phorbol esters, such as 12-0-tetradecanoylphorbol-13-acetate (TPA), stimulate mouse peritoneal exudate macrophages to undergo DNA synthesis without added macrophage growth factor (MGF).	Tetradecanoylphorbol Acetate	78-81	kit ligand	Mus musculus	196-199
6969613-2	1981	TPA (1.0 X 10(-9) -5.0 X 10(-11) M) increased KG-1 clonal growth by four to tenfold in the presence of suboptimal concentrations of colony stimulating factor (CSF) and by two to fourfold in the presence of maximally stimulating concentrations of CSF.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 2	Homo sapiens	132-157
6969613-2	1981	TPA (1.0 X 10(-9) -5.0 X 10(-11) M) increased KG-1 clonal growth by four to tenfold in the presence of suboptimal concentrations of colony stimulating factor (CSF) and by two to fourfold in the presence of maximally stimulating concentrations of CSF.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 2	Homo sapiens	159-162
6969613-2	1981	TPA (1.0 X 10(-9) -5.0 X 10(-11) M) increased KG-1 clonal growth by four to tenfold in the presence of suboptimal concentrations of colony stimulating factor (CSF) and by two to fourfold in the presence of maximally stimulating concentrations of CSF.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 2	Homo sapiens	246-249
6969613-4	1981	Only slight CSF activity was detected in the conditioned medium from KG-1 cells cultured in liquid medium with TPA.	Tetradecanoylphorbol Acetate	111-114	colony stimulating factor 2	Homo sapiens	12-15
7225106-0	1981	The tumor promoting phorbol diester, 12-O-tetradecanoylphorbol-13-acetate (TPA) increases glyoxalase I and decreases glyoxalase II activity in human polymorphonuclear leukocytes.	Tetradecanoylphorbol Acetate	37-73	glyoxalase I	Homo sapiens	90-102
7225106-0	1981	The tumor promoting phorbol diester, 12-O-tetradecanoylphorbol-13-acetate (TPA) increases glyoxalase I and decreases glyoxalase II activity in human polymorphonuclear leukocytes.	Tetradecanoylphorbol Acetate	75-78	glyoxalase I	Homo sapiens	90-102
7326828-0	1981	Induction of rat hepatic ornithine decarboxylase by the tumor promotors 12-O-tetradecanoylphorbol-13-acetate and phenobarbital in vivo; effect of retinyl-acetate.	Tetradecanoylphorbol Acetate	72-108	ornithine decarboxylase 1	Rattus norvegicus	25-48
7326828-2	1981	injection in rats of 20 microgram 12-O-tetradecanoylphorbol-13-acetate (TPA) or 100 mg phenobarbital (PB)/kg body weight resulted in a transient increase in liver ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	34-70	ornithine decarboxylase 1	Rattus norvegicus	163-186
7326828-2	1981	injection in rats of 20 microgram 12-O-tetradecanoylphorbol-13-acetate (TPA) or 100 mg phenobarbital (PB)/kg body weight resulted in a transient increase in liver ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	34-70	ornithine decarboxylase 1	Rattus norvegicus	188-191
7326828-2	1981	injection in rats of 20 microgram 12-O-tetradecanoylphorbol-13-acetate (TPA) or 100 mg phenobarbital (PB)/kg body weight resulted in a transient increase in liver ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	72-75	ornithine decarboxylase 1	Rattus norvegicus	163-186
7326828-2	1981	injection in rats of 20 microgram 12-O-tetradecanoylphorbol-13-acetate (TPA) or 100 mg phenobarbital (PB)/kg body weight resulted in a transient increase in liver ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	72-75	ornithine decarboxylase 1	Rattus norvegicus	188-191
7326828-3	1981	Maximal stimulation of ODC activity was observed approximately 4 h after application of TPA and 4-6 h after treatment of PB.	Tetradecanoylphorbol Acetate	88-91	ornithine decarboxylase 1	Rattus norvegicus	23-26
7326828-5	1981	ODC activity induction occurred in a dose dependent manner, maximal stimulation was obtained with 20-100 microgram TPA and 100 mg PB/kg body weight, respectively.	Tetradecanoylphorbol Acetate	115-118	ornithine decarboxylase 1	Rattus norvegicus	0-3
7326828-7	1981	The in vivo induction of rat liver ODC activity by TPA appeared to be under transcriptional control since administration of 2 mg actinomycin D/kg body weight or 50 mg cycloheximide/kg body weight 1 h prior to application of the tumor promotor prevented the increase of ODC activity.	Tetradecanoylphorbol Acetate	51-54	ornithine decarboxylase 1	Rattus norvegicus	35-38
7326828-7	1981	The in vivo induction of rat liver ODC activity by TPA appeared to be under transcriptional control since administration of 2 mg actinomycin D/kg body weight or 50 mg cycloheximide/kg body weight 1 h prior to application of the tumor promotor prevented the increase of ODC activity.	Tetradecanoylphorbol Acetate	51-54	ornithine decarboxylase 1	Rattus norvegicus	269-272
7326828-8	1981	Furthermore the TPA-stimulated ODC induction was shown to be very sensitive to retinyl-acetate (RA).	Tetradecanoylphorbol Acetate	16-19	ornithine decarboxylase 1	Rattus norvegicus	31-34
7326828-11	1981	Increasing the dose of RA to 20 microgram/kg body weight completely prevented the stimulation of ODC activity by TPA.	Tetradecanoylphorbol Acetate	113-116	ornithine decarboxylase 1	Rattus norvegicus	97-100
7213378-0	1980	Induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13 acetate in rat tissues.	Tetradecanoylphorbol Acetate	40-76	ornithine decarboxylase 1	Rattus norvegicus	13-36
11272120-1	1980	This study analyzes the mechanism by which the tumor promoter 12-0-tetradecanoyl-phorbol 13-acetate (TPA) inhibits binding of epidermal growth factor (EGF) to its membrane receptors in HeLa cells.	Tetradecanoylphorbol Acetate	101-104	epidermal growth factor	Homo sapiens	126-149
11272120-1	1980	This study analyzes the mechanism by which the tumor promoter 12-0-tetradecanoyl-phorbol 13-acetate (TPA) inhibits binding of epidermal growth factor (EGF) to its membrane receptors in HeLa cells.	Tetradecanoylphorbol Acetate	101-104	epidermal growth factor	Homo sapiens	151-154
11272120-2	1980	Kinetic studies indicate that inhibition of EGF binding occurs within a few minutes after exposure of cells to TPA; delayed addition of TPA causes a reduction in previously bound EGF.	Tetradecanoylphorbol Acetate	111-114	epidermal growth factor	Homo sapiens	44-47
11272120-2	1980	Kinetic studies indicate that inhibition of EGF binding occurs within a few minutes after exposure of cells to TPA; delayed addition of TPA causes a reduction in previously bound EGF.	Tetradecanoylphorbol Acetate	136-139	epidermal growth factor	Homo sapiens	179-182
11272120-3	1980	With prolonged exposure to TPA, the cells become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	27-30	epidermal growth factor	Homo sapiens	81-84
11272120-3	1980	With prolonged exposure to TPA, the cells become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	63-66	epidermal growth factor	Homo sapiens	81-84
11272120-4	1980	Evidence was obtained that TPA acts by causing the dissociation of EGF-receptor complexes present on the cell surface and not by increasing the proteolytic degradation or internalization of EGF.	Tetradecanoylphorbol Acetate	27-30	epidermal growth factor	Homo sapiens	67-70
11272120-5	1980	Evidence that the TPA inhibition of EGF-receptor binding is not a direct consequence of TPA binding to the "active site" of EGF receptors was obtained by the differential effects of pH, temperature or exposure time and that TPA does not inhibit EGF binding when added to isolated plasma membrane fragments.	Tetradecanoylphorbol Acetate	18-21	epidermal growth factor	Homo sapiens	36-39
11272120-6	1980	Studies with a variety of inhibitors suggest that the TPA inhibition of EGF-receptor binding does not require macromolecular synthesis, energy metabolism, or cytoskeletal changes.	Tetradecanoylphorbol Acetate	54-57	epidermal growth factor	Homo sapiens	72-75
7189486-3	1980	Cultured ACR cells showed an unusual biphasic dose response to TPA.	Tetradecanoylphorbol Acetate	63-66	acrosin	Homo sapiens	9-12
315558-1	1979	In previous studies we demonstrated that the tumor-promoting agent 12-O-tetradecanoyl phorbol 13-acetate (TPA) and related macrocyclic diterpenes are potent inhibitors of the binding of epidermal growth factor (EGF) to its cell surface receptors in HeLa cells.	Tetradecanoylphorbol Acetate	67-104	epidermal growth factor	Homo sapiens	186-209
315558-1	1979	In previous studies we demonstrated that the tumor-promoting agent 12-O-tetradecanoyl phorbol 13-acetate (TPA) and related macrocyclic diterpenes are potent inhibitors of the binding of epidermal growth factor (EGF) to its cell surface receptors in HeLa cells.	Tetradecanoylphorbol Acetate	67-104	epidermal growth factor	Homo sapiens	211-214
315558-1	1979	In previous studies we demonstrated that the tumor-promoting agent 12-O-tetradecanoyl phorbol 13-acetate (TPA) and related macrocyclic diterpenes are potent inhibitors of the binding of epidermal growth factor (EGF) to its cell surface receptors in HeLa cells.	Tetradecanoylphorbol Acetate	106-109	epidermal growth factor	Homo sapiens	186-209
287029-4	1979	TPA causes an inhibition of expression of all hexamethylene bisacetamide-inducible erythroid characteristics measured, including commitment to terminal cell division, accumulation of globin mRNA, and synthesis of globins, spectrin, heme synthetic enzymes (delta-aminolevulinic acid dehydratase and uroporphyrinogen-I synthase) and heme.	Tetradecanoylphorbol Acetate	0-3	aminolevulinate, delta-, dehydratase	Mus musculus	256-293
33281120-3	2021	Kaempferol suppressed the production and gene expression of MUC5AC mucins, induced by PMA through the inhibition of degradation of inhibitory kappa Balpha (IkappaBalpha), and NF-kappaB p65 nuclear translocation.	Tetradecanoylphorbol Acetate	86-89	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	60-66
33871880-2	2021	In this study, two novel violet-blue bipolar fluorophores , TPA-PI-SBF and SBF-PI-SBF , were designed and synthesized by introducing the hole transporting moiety triphenylamine (TPA) and spirobifluorene (SBF) unit that has high T 1 into high deep blue emission quantum yield group phenanthroimidazole (PI).	Tetradecanoylphorbol Acetate	60-63	zinc finger protein 143	Homo sapiens	67-70
33954180-9	2021	In TPA model, both hydrocortisone and emollient significantly decreased expression levels of IL-1alpha, IL-1beta, IL-6, and TNFalpha mRNA.	Tetradecanoylphorbol Acetate	3-6	interleukin 1 alpha	Mus musculus	93-102
33954180-9	2021	In TPA model, both hydrocortisone and emollient significantly decreased expression levels of IL-1alpha, IL-1beta, IL-6, and TNFalpha mRNA.	Tetradecanoylphorbol Acetate	3-6	interleukin 1 alpha	Mus musculus	104-112
33846306-9	2021	Here we show that while endogenous ASK1 is dispensable for skin homeostasis, ASK1KO mice are resistant to DMBA/TPA-induced tumorigenesis.	Tetradecanoylphorbol Acetate	111-114	mitogen-activated protein kinase kinase kinase 5	Mus musculus	77-83
33846306-10	2021	However, we found that epidermis lacking both p21 and ASK1 reacquires increased sensitivity to DMBA/TPA-induced tumorigenesis.	Tetradecanoylphorbol Acetate	100-103	mitogen-activated protein kinase kinase kinase 5	Mus musculus	54-58
33841142-7	2021	The secretion and the mRNA expression of cytokines related to TLR4 signaling significantly increased after SYQP treatment in both PMA-induced THP-1 and RAW264.7 macrophage cell lines.	Tetradecanoylphorbol Acetate	130-133	toll like receptor 4	Homo sapiens	62-66
33676894-6	2021	Kv1.5, but not Kv1.1, Kv1.2, Kv1.3 or Kv1.4, was uniquely sensitive to PMA treatment.	Tetradecanoylphorbol Acetate	71-74	potassium voltage-gated channel subfamily A member 4	Homo sapiens	38-43
33717151-3	2021	In this study, we investigated the effect of SOD3 on anti-CD3/CD28- or phorbol myristate acetate (PMA) and ionomycin (ION)-mediated activation of mouse naive CD4+ T cells.	Tetradecanoylphorbol Acetate	71-96	superoxide dismutase 3, extracellular	Mus musculus	45-49
33717151-3	2021	In this study, we investigated the effect of SOD3 on anti-CD3/CD28- or phorbol myristate acetate (PMA) and ionomycin (ION)-mediated activation of mouse naive CD4+ T cells.	Tetradecanoylphorbol Acetate	98-101	superoxide dismutase 3, extracellular	Mus musculus	45-49
33475631-3	2021	In this work, a steric hindrance effect was observed in a quinoline-involved polypyridyl Co complex-based water reduction catalyst (WRC), which impedes the formation of Co(iii)-H from Co(i), two pivotal intermediates for H2 evolution, leading to significantly impaired electrocatalytic and photocatalytic activity with respect to its parent complex, [Co(TPA)Cl]Cl (TPA = tris(2-pyridinylmethyl)-amine).	Tetradecanoylphorbol Acetate	354-357	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	184-189
32803665-5	2021	PGAL decreased IL-6, TNF-alpha, and IL-1beta production in human monocytes exposed to PMA without affecting cell viability.	Tetradecanoylphorbol Acetate	86-89	interleukin 1 alpha	Homo sapiens	36-44
3257768-10	1988	In response to PMA and ionomycin (without added IL-2), only RL-73- HSA-cells proliferated and this proliferation was correlated with IL-2 production.	Tetradecanoylphorbol Acetate	15-18	interleukin 2	Mus musculus	133-137
3278921-5	1988	Down regulation of PKC activity by treatment with TPA for 48-h blocks the stimulation of S6 kinase by TPA but leaves the activation by EGF, IGF-I and insulin unaffected.	Tetradecanoylphorbol Acetate	50-53	epidermal growth factor	Homo sapiens	135-138
2448301-1	1988	Activators of protein kinase C such as 1-oleoyl-2-acetylglycerol, mezerein, and the phorbol esters phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-didecanoate induced a time-dependent increase in proenkephalin mRNA levels, whereas the inactive phorbol ester 4 alpha-phorbol 12,13-didecanoate had no effect.	Tetradecanoylphorbol Acetate	99-130	proenkephalin	Bos taurus	204-217
2448301-4	1988	However, when proenkephalin mRNA levels were stimulated by KCl (10 mM) and the dihydropyridine BayK8644, PMA exhibited an inhibitory effect on proenkephalin mRNA, which was detectable at a 10-fold lower concentration of PMA than the stimulatory effect.	Tetradecanoylphorbol Acetate	105-108	proenkephalin	Bos taurus	14-27
2448301-4	1988	However, when proenkephalin mRNA levels were stimulated by KCl (10 mM) and the dihydropyridine BayK8644, PMA exhibited an inhibitory effect on proenkephalin mRNA, which was detectable at a 10-fold lower concentration of PMA than the stimulatory effect.	Tetradecanoylphorbol Acetate	105-108	proenkephalin	Bos taurus	143-156
2448301-4	1988	However, when proenkephalin mRNA levels were stimulated by KCl (10 mM) and the dihydropyridine BayK8644, PMA exhibited an inhibitory effect on proenkephalin mRNA, which was detectable at a 10-fold lower concentration of PMA than the stimulatory effect.	Tetradecanoylphorbol Acetate	220-223	proenkephalin	Bos taurus	14-27
2448301-4	1988	However, when proenkephalin mRNA levels were stimulated by KCl (10 mM) and the dihydropyridine BayK8644, PMA exhibited an inhibitory effect on proenkephalin mRNA, which was detectable at a 10-fold lower concentration of PMA than the stimulatory effect.	Tetradecanoylphorbol Acetate	220-223	proenkephalin	Bos taurus	143-156
2448301-8	1988	Stimulation of phosphoinositide hydrolysis and proenkephalin mRNA by histaminic H1-receptor activation was inhibited by low concentrations of PMA.	Tetradecanoylphorbol Acetate	142-145	proenkephalin	Bos taurus	47-60
2827895-8	1988	BCGF-II in the presence of low doses (0.1 microgram/ml) of phorbol myristate acetate (PMA) also induced Tac Ag mRNA (3.5 and 1.5 kb) in these B-cell lines.	Tetradecanoylphorbol Acetate	59-84	interleukin 5	Mus musculus	0-7
3345508-1	1988	Ornithine decarboxylase (ODC) and histidine decarboxylase (HDC) activities of rat colon mucosa were induced after intrarectal instillation of 12-o-tetradecanoylphorbol-13-acetate (TPA) and sodium deoxycholate.	Tetradecanoylphorbol Acetate	142-178	ornithine decarboxylase 1	Rattus norvegicus	0-23
3345508-1	1988	Ornithine decarboxylase (ODC) and histidine decarboxylase (HDC) activities of rat colon mucosa were induced after intrarectal instillation of 12-o-tetradecanoylphorbol-13-acetate (TPA) and sodium deoxycholate.	Tetradecanoylphorbol Acetate	142-178	ornithine decarboxylase 1	Rattus norvegicus	25-28
3345508-1	1988	Ornithine decarboxylase (ODC) and histidine decarboxylase (HDC) activities of rat colon mucosa were induced after intrarectal instillation of 12-o-tetradecanoylphorbol-13-acetate (TPA) and sodium deoxycholate.	Tetradecanoylphorbol Acetate	180-183	ornithine decarboxylase 1	Rattus norvegicus	0-23
3345508-1	1988	Ornithine decarboxylase (ODC) and histidine decarboxylase (HDC) activities of rat colon mucosa were induced after intrarectal instillation of 12-o-tetradecanoylphorbol-13-acetate (TPA) and sodium deoxycholate.	Tetradecanoylphorbol Acetate	180-183	ornithine decarboxylase 1	Rattus norvegicus	25-28
3257235-2	1988	Activation of protein kinase C by the phorbol ester, tetradecanoyl phorbol acetate or other phorbol esters increases the levels of the alpha and beta T cell receptor (TcR-alpha, TcR-beta) mRNA, whereas an increase in cytosolic free Ca2+, induced by ionomycin or other Ca2+ ionophores, results in a decrease of alpha and beta TcR mRNA levels.	Tetradecanoylphorbol Acetate	53-82	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	178-186
3257235-2	1988	Activation of protein kinase C by the phorbol ester, tetradecanoyl phorbol acetate or other phorbol esters increases the levels of the alpha and beta T cell receptor (TcR-alpha, TcR-beta) mRNA, whereas an increase in cytosolic free Ca2+, induced by ionomycin or other Ca2+ ionophores, results in a decrease of alpha and beta TcR mRNA levels.	Tetradecanoylphorbol Acetate	53-82	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	167-170
3265879-5	1988	However, after stimulation with phorbol myristate acetate (PMA) and phytohemagglutinin (PHA), mRNAs for M-, G-, GM-CSF, and multi-CSF became detectable in PBMC as early as 6 hours after initiation of cultures.	Tetradecanoylphorbol Acetate	32-57	colony stimulating factor 2	Homo sapiens	112-118
3265879-5	1988	However, after stimulation with phorbol myristate acetate (PMA) and phytohemagglutinin (PHA), mRNAs for M-, G-, GM-CSF, and multi-CSF became detectable in PBMC as early as 6 hours after initiation of cultures.	Tetradecanoylphorbol Acetate	32-57	colony stimulating factor 2	Homo sapiens	115-118
3265879-5	1988	However, after stimulation with phorbol myristate acetate (PMA) and phytohemagglutinin (PHA), mRNAs for M-, G-, GM-CSF, and multi-CSF became detectable in PBMC as early as 6 hours after initiation of cultures.	Tetradecanoylphorbol Acetate	59-62	colony stimulating factor 2	Homo sapiens	112-118
3265879-5	1988	However, after stimulation with phorbol myristate acetate (PMA) and phytohemagglutinin (PHA), mRNAs for M-, G-, GM-CSF, and multi-CSF became detectable in PBMC as early as 6 hours after initiation of cultures.	Tetradecanoylphorbol Acetate	59-62	colony stimulating factor 2	Homo sapiens	115-118
3257564-5	1988	Approximately 1 of 10 fetal thymocytes at day 14 of gestation expressed mRNA for IL-4 after their stimulation by phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	113-144	interleukin 4	Mus musculus	81-85
3273203-5	1988	Since CsA inhibits specifically 12-O-tetradecanoylphorbol-13-acetate (TAP)-stimulated but not basal protein synthesis in epidermis, it is proposed that Ca2+/calmodulin-dependent phosphorylation of EF-2 is involved in the induction of the hyperplastic response by TPA and that CsA suppresses TPA effects by inhibition of EF-2-phosphorylation and perhaps other calmodulin-dependent processes.	Tetradecanoylphorbol Acetate	32-68	eukaryotic translation elongation factor 2	Mus musculus	197-201
2894235-3	1987	Pretreatment of the neuronal cultures with 1 microM phorbol myristate acetate (PMA) inhibited alpha 1, muscarinic, and glutamate receptor-mediated PI hydrolysis in a time-dependent manner with maximal inhibition observed after a 20-30 min preincubation.	Tetradecanoylphorbol Acetate	52-77	adrenoceptor alpha 1D	Homo sapiens	94-137
2894235-3	1987	Pretreatment of the neuronal cultures with 1 microM phorbol myristate acetate (PMA) inhibited alpha 1, muscarinic, and glutamate receptor-mediated PI hydrolysis in a time-dependent manner with maximal inhibition observed after a 20-30 min preincubation.	Tetradecanoylphorbol Acetate	79-82	adrenoceptor alpha 1D	Homo sapiens	94-137
3121729-15	1987	mRNA analysis of adult L3T4-/Lyt-2- thymocytes stimulated with A23187 and phorbol myristate acetate confirms that mRNA for both IL-4 and IFN-gamma is induced in adult L3T4-/Lyt-2- thymocytes.	Tetradecanoylphorbol Acetate	74-99	interleukin 4	Mus musculus	128-132
3678137-9	1987	12-O-Tetradecanoylphorbol 13-acetate, (a phorbol ester; 50 nM), a potent activator of protein kinase C, strongly stimulated GH secretion (347%), which was similarly suppressed by IGF-I by 51%.	Tetradecanoylphorbol Acetate	0-36	insulin-like growth factor 1	Rattus norvegicus	179-184
3325828-2	1987	The cDNA was used to study the regulation of PAI-2 gene transcription by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate in the human histiocytic lymphoma cell line U-937.	Tetradecanoylphorbol Acetate	107-138	serpin family B member 2	Homo sapiens	45-50
3663711-3	1987	During the activation of neutrophils with serum-opsonised zymosan and the tumour-promoting phorbol diester 12-O-tetradecanoylphorbol 13-acetate, the activity of glyoxalase I increases and the activity of glyoxalase II decreases by 20-40% of their activities in resting cells, in the initial 10 min of the activation period.	Tetradecanoylphorbol Acetate	107-143	glyoxalase I	Homo sapiens	161-173
2896538-5	1987	Both somatostatin and insulin-like growth factor I inhibit GH release stimulated by TPA to the same extent as that stimulated by GRF, showing that the normal inhibitory control mechanism of release is not altered.	Tetradecanoylphorbol Acetate	84-87	insulin-like growth factor 1	Rattus norvegicus	22-50
3115340-7	1987	PMA-treated blast cells, however, generated B cell colonies in the presence of rIL2, thus suggesting that PMA could induce functional IL2-R on immature leukemic B cells.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Rattus norvegicus	79-83
3115340-7	1987	PMA-treated blast cells, however, generated B cell colonies in the presence of rIL2, thus suggesting that PMA could induce functional IL2-R on immature leukemic B cells.	Tetradecanoylphorbol Acetate	106-109	interleukin 2	Rattus norvegicus	79-83
3498715-5	1987	Phorbol 12-myristate 13-acetate (PMA) leads to the rapid internalization of up to 65% of the surface A2B4-2 or A2B4-2 Fab fragments.	Tetradecanoylphorbol Acetate	0-31	FA complementation group B	Homo sapiens	118-121
3498715-5	1987	Phorbol 12-myristate 13-acetate (PMA) leads to the rapid internalization of up to 65% of the surface A2B4-2 or A2B4-2 Fab fragments.	Tetradecanoylphorbol Acetate	33-36	FA complementation group B	Homo sapiens	118-121
3502083-5	1987	Addition of phorbol myristate acetate to monocytes caused only partial normalization of the decreased IL-1 production.	Tetradecanoylphorbol Acetate	12-37	interleukin 1 alpha	Homo sapiens	102-106
3306603-5	1987	In contrast, c-myc mRNA expression is both in TPA- and DMSO-induced differentiation reduced to less then 5% of its initial level within 4h.	Tetradecanoylphorbol Acetate	46-49	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	13-18
3306603-6	1987	Nuclear run-on analysis revealed that the reduction of c-myc-mRNA expression during both TPA- and DMSO-induced differentiation could be ascribed to the abolition of transcription of the third exon, whereas no change in the transcription of the first exon could be observed.	Tetradecanoylphorbol Acetate	89-92	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	55-60
3112228-6	1987	In cultures of resident peritoneal macrophages, phorbol myristate acetate and cholera toxin increase the synthesis of the Mr 55,000 secreted PAI, whereas dexamethasone decreases the synthesis of both PAI; the production of PAI is also enhanced in the presence of macrophage colony-stimulating factor (CSF-1).	Tetradecanoylphorbol Acetate	48-73	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	141-144
3301855-2	1987	Using two-dimensional gel electrophoresis, we found that activation of B cells by mitogens (anti-immunoglobulin antibody, lipopolysaccharide, phorbol 12-myristate 13-acetate (PMA)/A23187) was associated with a rapid and prominent (5-20-fold) increase in the synthesis of a 40-kDa/pI 5.0 nuclear protein, here termed numatrin.	Tetradecanoylphorbol Acetate	142-173	nucleophosmin 1	Mus musculus	316-324
3301855-2	1987	Using two-dimensional gel electrophoresis, we found that activation of B cells by mitogens (anti-immunoglobulin antibody, lipopolysaccharide, phorbol 12-myristate 13-acetate (PMA)/A23187) was associated with a rapid and prominent (5-20-fold) increase in the synthesis of a 40-kDa/pI 5.0 nuclear protein, here termed numatrin.	Tetradecanoylphorbol Acetate	175-178	nucleophosmin 1	Mus musculus	316-324
2440910-6	1987	H2O2 release in the range seen in sarcoid patients could be induced in PMA-triggered AM from normals by rIFN gamma in a time- (t1/2 approximately 1 d) and dose-dependent fashion (threefold increase, EC50 5 antiviral U/ml) and by rIFN alpha A and rIFN beta at higher concentrations, but not by 1,25-dihydroxyvitamin D3.	Tetradecanoylphorbol Acetate	71-74	interferon gamma	Rattus norvegicus	104-114
2440910-6	1987	H2O2 release in the range seen in sarcoid patients could be induced in PMA-triggered AM from normals by rIFN gamma in a time- (t1/2 approximately 1 d) and dose-dependent fashion (threefold increase, EC50 5 antiviral U/ml) and by rIFN alpha A and rIFN beta at higher concentrations, but not by 1,25-dihydroxyvitamin D3.	Tetradecanoylphorbol Acetate	71-74	interferon beta 1	Rattus norvegicus	246-255
3112932-1	1987	We investigated whether the protein kinase C-binding agents 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and 1-oleoyl-2-acetyl-rac-glycerol (OAG) induced reactivity to interleukin 2 (IL-2) in mouse lymphocytes.	Tetradecanoylphorbol Acetate	60-97	interleukin 2	Mus musculus	167-180
3112932-1	1987	We investigated whether the protein kinase C-binding agents 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and 1-oleoyl-2-acetyl-rac-glycerol (OAG) induced reactivity to interleukin 2 (IL-2) in mouse lymphocytes.	Tetradecanoylphorbol Acetate	60-97	interleukin 2	Mus musculus	182-186
3112932-1	1987	We investigated whether the protein kinase C-binding agents 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and 1-oleoyl-2-acetyl-rac-glycerol (OAG) induced reactivity to interleukin 2 (IL-2) in mouse lymphocytes.	Tetradecanoylphorbol Acetate	99-102	interleukin 2	Mus musculus	167-180
3112932-1	1987	We investigated whether the protein kinase C-binding agents 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and 1-oleoyl-2-acetyl-rac-glycerol (OAG) induced reactivity to interleukin 2 (IL-2) in mouse lymphocytes.	Tetradecanoylphorbol Acetate	99-102	interleukin 2	Mus musculus	182-186
3112932-2	1987	10(-8) M TPA was a strong inducer of reactivity to IL-2 measured by [3H]thymidine incorporation.	Tetradecanoylphorbol Acetate	9-12	interleukin 2	Mus musculus	51-55
3112932-6	1987	The expression of reactivity to IL-2 induced by A 23187 + OAG was inhibited by 0.04 mM Mn2+; in contrast the TPA-mediated induction of IL-2 responsiveness was not affected by Mn2+.	Tetradecanoylphorbol Acetate	109-112	interleukin 2	Mus musculus	135-139
3112932-7	1987	The data suggest differences in the mechanism of induction of IL-2 responsiveness by the two protein kinase C-binding agents, TPA and OAG.	Tetradecanoylphorbol Acetate	126-129	interleukin 2	Mus musculus	62-66
3495533-2	1987	PMA, carbachol, and EGF all stimulated rapid accumulation of mRNA for the proto-oncogenes c-fos and c-myc in the normal cells; in the protein kinase C-deficient cells, carbachol and EGF, but not PMA, retained this effect, which was not mimicked by the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	0-3	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	100-105
3495533-2	1987	PMA, carbachol, and EGF all stimulated rapid accumulation of mRNA for the proto-oncogenes c-fos and c-myc in the normal cells; in the protein kinase C-deficient cells, carbachol and EGF, but not PMA, retained this effect, which was not mimicked by the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor	Homo sapiens	182-185
3034665-3	1987	When stimulated by 12-O-tetradecanoyl phorbol 13-acetate, macrophages displayed a biphasic pHi change: a marginal acidification followed by an alkalinization.	Tetradecanoylphorbol Acetate	19-56	glucose-6-phosphate isomerase	Rattus norvegicus	91-94
3105621-3	1987	Expression of the M-CSF gene was induced in blood mononuclear cells stimulated by phorbol myristate acetate (PMA) or gamma-interferon.	Tetradecanoylphorbol Acetate	82-107	colony stimulating factor 1	Homo sapiens	18-23
3105621-3	1987	Expression of the M-CSF gene was induced in blood mononuclear cells stimulated by phorbol myristate acetate (PMA) or gamma-interferon.	Tetradecanoylphorbol Acetate	109-112	colony stimulating factor 1	Homo sapiens	18-23
3108018-4	1987	Exposure to rIFN-gamma led to an enhanced chemiluminescence (CL) signal in the presence of luminol and a variety of respiratory burst stimuli, such as zymosan, phorbol 12-myristate 13-acetate or IgG-sensitized sheep erythrocytes (EA).	Tetradecanoylphorbol Acetate	160-191	interferon gamma	Rattus norvegicus	12-22
3495445-5	1987	Stimulation of B lymphocytes with TPA plus ionomycin resulted in increased magnitude and a shift in the kinetics of c-fos and c-myc expression compared with either agent used alone.	Tetradecanoylphorbol Acetate	34-37	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	126-131
2885743-2	1987	CAD regulation was studied in the human promyelocyte leukemic line HL-60 as it differentiated into monocytic or granulocytic lineages after induction by 12-O-tetradecanoylphorbol-13-acetate or trans-retinoic acid and dibutyryl cyclic AMP, respectively.	Tetradecanoylphorbol Acetate	153-189	aconitate decarboxylase 1	Homo sapiens	0-3
2887201-1	1987	In adrenalectomized rats, the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the inductions of tyrosine aminotransferase (TAT) and ornithine decarboxylase by glucocorticoids, even with sufficient concentration of glucocorticoids to have a maximal effect, whereas it had no effect on TAT activity and increased ornithine decarboxylase activity only slightly in the absence of glucocorticoids.	Tetradecanoylphorbol Acetate	60-96	tyrosine aminotransferase	Rattus norvegicus	139-164
2887201-1	1987	In adrenalectomized rats, the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the inductions of tyrosine aminotransferase (TAT) and ornithine decarboxylase by glucocorticoids, even with sufficient concentration of glucocorticoids to have a maximal effect, whereas it had no effect on TAT activity and increased ornithine decarboxylase activity only slightly in the absence of glucocorticoids.	Tetradecanoylphorbol Acetate	60-96	tyrosine aminotransferase	Rattus norvegicus	166-169
2887201-1	1987	In adrenalectomized rats, the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the inductions of tyrosine aminotransferase (TAT) and ornithine decarboxylase by glucocorticoids, even with sufficient concentration of glucocorticoids to have a maximal effect, whereas it had no effect on TAT activity and increased ornithine decarboxylase activity only slightly in the absence of glucocorticoids.	Tetradecanoylphorbol Acetate	60-96	ornithine decarboxylase 1	Rattus norvegicus	175-198
2887201-1	1987	In adrenalectomized rats, the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the inductions of tyrosine aminotransferase (TAT) and ornithine decarboxylase by glucocorticoids, even with sufficient concentration of glucocorticoids to have a maximal effect, whereas it had no effect on TAT activity and increased ornithine decarboxylase activity only slightly in the absence of glucocorticoids.	Tetradecanoylphorbol Acetate	60-96	tyrosine aminotransferase	Rattus norvegicus	327-330
2887201-1	1987	In adrenalectomized rats, the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the inductions of tyrosine aminotransferase (TAT) and ornithine decarboxylase by glucocorticoids, even with sufficient concentration of glucocorticoids to have a maximal effect, whereas it had no effect on TAT activity and increased ornithine decarboxylase activity only slightly in the absence of glucocorticoids.	Tetradecanoylphorbol Acetate	60-96	ornithine decarboxylase 1	Rattus norvegicus	354-377
2887201-1	1987	In adrenalectomized rats, the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the inductions of tyrosine aminotransferase (TAT) and ornithine decarboxylase by glucocorticoids, even with sufficient concentration of glucocorticoids to have a maximal effect, whereas it had no effect on TAT activity and increased ornithine decarboxylase activity only slightly in the absence of glucocorticoids.	Tetradecanoylphorbol Acetate	98-101	tyrosine aminotransferase	Rattus norvegicus	139-164
2887201-1	1987	In adrenalectomized rats, the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the inductions of tyrosine aminotransferase (TAT) and ornithine decarboxylase by glucocorticoids, even with sufficient concentration of glucocorticoids to have a maximal effect, whereas it had no effect on TAT activity and increased ornithine decarboxylase activity only slightly in the absence of glucocorticoids.	Tetradecanoylphorbol Acetate	98-101	tyrosine aminotransferase	Rattus norvegicus	166-169
2887201-1	1987	In adrenalectomized rats, the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the inductions of tyrosine aminotransferase (TAT) and ornithine decarboxylase by glucocorticoids, even with sufficient concentration of glucocorticoids to have a maximal effect, whereas it had no effect on TAT activity and increased ornithine decarboxylase activity only slightly in the absence of glucocorticoids.	Tetradecanoylphorbol Acetate	98-101	ornithine decarboxylase 1	Rattus norvegicus	175-198
2887201-1	1987	In adrenalectomized rats, the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the inductions of tyrosine aminotransferase (TAT) and ornithine decarboxylase by glucocorticoids, even with sufficient concentration of glucocorticoids to have a maximal effect, whereas it had no effect on TAT activity and increased ornithine decarboxylase activity only slightly in the absence of glucocorticoids.	Tetradecanoylphorbol Acetate	98-101	tyrosine aminotransferase	Rattus norvegicus	327-330
2887201-1	1987	In adrenalectomized rats, the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) markedly enhanced the inductions of tyrosine aminotransferase (TAT) and ornithine decarboxylase by glucocorticoids, even with sufficient concentration of glucocorticoids to have a maximal effect, whereas it had no effect on TAT activity and increased ornithine decarboxylase activity only slightly in the absence of glucocorticoids.	Tetradecanoylphorbol Acetate	98-101	ornithine decarboxylase 1	Rattus norvegicus	354-377
2887201-2	1987	Phorbol derivatives and components of TPA such as 4 beta-phorbol, phorbol 12-tetradecanoate, phorbol 13-acetate, and 4-O-methylphorbol 12-tetradecanoate 13-acetate, which have no tumor-promoting activity or ability to activate protein kinase C, did not have any effect on TAT induction by glucocorticoid.	Tetradecanoylphorbol Acetate	38-41	tyrosine aminotransferase	Rattus norvegicus	272-275
2887201-3	1987	TPA enhanced the induction of TAT by various glucocorticoids but had no effect on induction of TAT by glucagon or insulin and did not enhance the induction of glucose-6-phosphate dehydrogenase by 17 beta-estradiol.	Tetradecanoylphorbol Acetate	0-3	tyrosine aminotransferase	Rattus norvegicus	30-33
2887201-4	1987	These results suggest that TPA specifically enhances the induction of TAT and ornithine decarboxylase by glucocorticoids.	Tetradecanoylphorbol Acetate	27-30	tyrosine aminotransferase	Rattus norvegicus	70-73
2887201-4	1987	These results suggest that TPA specifically enhances the induction of TAT and ornithine decarboxylase by glucocorticoids.	Tetradecanoylphorbol Acetate	27-30	ornithine decarboxylase 1	Rattus norvegicus	78-101
2887201-5	1987	Similar effects of TPA on TAT induction by glucocorticoid were observed in primary cultures of adult rat hepatocytes.	Tetradecanoylphorbol Acetate	19-22	tyrosine aminotransferase	Rattus norvegicus	26-29
3104323-3	1987	A combination of a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and a calcium ionophore, A23187, induced the expression of IL2 receptors on resting 6-1 cells and induced DNA synthesis in the presence of IL2.	Tetradecanoylphorbol Acetate	34-70	interleukin 2	Mus musculus	137-140
3104323-3	1987	A combination of a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and a calcium ionophore, A23187, induced the expression of IL2 receptors on resting 6-1 cells and induced DNA synthesis in the presence of IL2.	Tetradecanoylphorbol Acetate	34-70	interleukin 2	Mus musculus	217-220
3104323-3	1987	A combination of a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and a calcium ionophore, A23187, induced the expression of IL2 receptors on resting 6-1 cells and induced DNA synthesis in the presence of IL2.	Tetradecanoylphorbol Acetate	72-75	interleukin 2	Mus musculus	137-140
3104323-3	1987	A combination of a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and a calcium ionophore, A23187, induced the expression of IL2 receptors on resting 6-1 cells and induced DNA synthesis in the presence of IL2.	Tetradecanoylphorbol Acetate	72-75	interleukin 2	Mus musculus	217-220
3104323-7	1987	Resting KO.6 cells produced IL2 in response to a combination of TPA and A23187, whereas either one of the agents did not induce the production of IL2.	Tetradecanoylphorbol Acetate	64-67	interleukin 2	Mus musculus	28-31
3104323-10	1987	On the contrary, signals for DNA synthesis generated by binding of IL2 to IL2 receptors are different from those for IL2 production and IL2 receptor expression, as the combination of TPA and A23187 could not induce DNA synthesis without IL2.	Tetradecanoylphorbol Acetate	183-186	interleukin 2	Mus musculus	67-70
3104323-10	1987	On the contrary, signals for DNA synthesis generated by binding of IL2 to IL2 receptors are different from those for IL2 production and IL2 receptor expression, as the combination of TPA and A23187 could not induce DNA synthesis without IL2.	Tetradecanoylphorbol Acetate	183-186	interleukin 2	Mus musculus	74-77
3104323-10	1987	On the contrary, signals for DNA synthesis generated by binding of IL2 to IL2 receptors are different from those for IL2 production and IL2 receptor expression, as the combination of TPA and A23187 could not induce DNA synthesis without IL2.	Tetradecanoylphorbol Acetate	183-186	interleukin 2	Mus musculus	74-77
3104323-10	1987	On the contrary, signals for DNA synthesis generated by binding of IL2 to IL2 receptors are different from those for IL2 production and IL2 receptor expression, as the combination of TPA and A23187 could not induce DNA synthesis without IL2.	Tetradecanoylphorbol Acetate	183-186	interleukin 2	Mus musculus	74-77
3104323-10	1987	On the contrary, signals for DNA synthesis generated by binding of IL2 to IL2 receptors are different from those for IL2 production and IL2 receptor expression, as the combination of TPA and A23187 could not induce DNA synthesis without IL2.	Tetradecanoylphorbol Acetate	183-186	interleukin 2	Mus musculus	74-77
33188146-7	2021	Consequently, PU.1-S41,S140A retained its transactivation, DNA binding ability and promoted monocyte-macrophage differentiation of U937 cells even without PMA treatment.	Tetradecanoylphorbol Acetate	155-158	Spi-1 proto-oncogene	Homo sapiens	14-18
33404030-8	2021	Quantitative cell viability analysis suggests that TPA-DPPy exhibits an outstanding phototoxicity toward LDLR-overexpressing A549 cancer cells, with a killing efficiency of ca.	Tetradecanoylphorbol Acetate	51-54	low density lipoprotein receptor	Homo sapiens	105-109
1382058-6	1992	Furthermore, co-stimulation of the phorbol 12-myristate 13-acetate and anti-CD3 mAb intensely provoked the transgenic thymocytes to release IL-2.	Tetradecanoylphorbol Acetate	35-66	interleukin 2	Mus musculus	140-144
1387667-10	1992	The demonstrated cooperativity between the AP-1 and the 3" flanking sequence to confer TPA inducibility can thus be explained by the individual contributions of jun/fos and ets transactivators.	Tetradecanoylphorbol Acetate	87-90	FBJ osteosarcoma oncogene	Mus musculus	165-168
1382409-8	1992	Pretreatment of cells with PMA had no effect on [3H]PAF binding, but abolished the PAF-induced gene expression.	Tetradecanoylphorbol Acetate	27-30	PCNA clamp associated factor	Homo sapiens	83-86
1501891-3	1992	In addition, constitutive expression of exogenous myc inhibited induced differentiation of these cells by a variety of treatments including addition to the medium of lipopolysaccharide (LPS) or the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) as well as complete withdrawal of serum from the medium.	Tetradecanoylphorbol Acetate	212-249	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	50-53
1501891-3	1992	In addition, constitutive expression of exogenous myc inhibited induced differentiation of these cells by a variety of treatments including addition to the medium of lipopolysaccharide (LPS) or the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) as well as complete withdrawal of serum from the medium.	Tetradecanoylphorbol Acetate	251-254	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	50-53
1639858-5	1992	The c-myc proto-oncogene, known to have a high constitutive expression in actively proliferating cells, was strongly downregulated by TPA, but calcium had no effect over a 32 hour period, consistent with the greater growth inhibition of TPA in this system.	Tetradecanoylphorbol Acetate	134-137	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	4-9
1639858-5	1992	The c-myc proto-oncogene, known to have a high constitutive expression in actively proliferating cells, was strongly downregulated by TPA, but calcium had no effect over a 32 hour period, consistent with the greater growth inhibition of TPA in this system.	Tetradecanoylphorbol Acetate	237-240	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	4-9
1506773-10	1992	The down-regulation of the differentiation-related oncogenes c-myc and c-myb was the same in cells treated with TPA in the presence or absence of glucocorticoids.	Tetradecanoylphorbol Acetate	112-115	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	61-66
1506773-10	1992	The down-regulation of the differentiation-related oncogenes c-myc and c-myb was the same in cells treated with TPA in the presence or absence of glucocorticoids.	Tetradecanoylphorbol Acetate	112-115	MYB proto-oncogene, transcription factor	Homo sapiens	71-76
1634545-0	1992	Interaction of AP-1-, AP-2-, and Sp1-like proteins with two distinct sites in the upstream regulatory region of the plasminogen activator inhibitor-1 gene mediates the phorbol 12-myristate 13-acetate response.	Tetradecanoylphorbol Acetate	168-199	serpin family E member 1	Homo sapiens	116-149
1634545-1	1992	Phorbol 12-myristate 13-acetate induces a 3- and 10-fold induction of chloramphenicol acetyltransferase (CAT) activity in HT1080 and HeLa cells, respectively, following transient transfection of a 336-base pair plasminogen activator inhibitor-1 (PAI-1) promoter fragment linked to a CAT reporter gene.	Tetradecanoylphorbol Acetate	0-31	serpin family E member 1	Homo sapiens	211-244
1634545-1	1992	Phorbol 12-myristate 13-acetate induces a 3- and 10-fold induction of chloramphenicol acetyltransferase (CAT) activity in HT1080 and HeLa cells, respectively, following transient transfection of a 336-base pair plasminogen activator inhibitor-1 (PAI-1) promoter fragment linked to a CAT reporter gene.	Tetradecanoylphorbol Acetate	0-31	serpin family E member 1	Homo sapiens	246-251
1377987-5	1992	In addition, the pyruvate kinase C (PKC) pathway does not seem to participate in the process either because in our system activation of PKC by 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) is insufficient by itself to induce HLA-DR. We found, however, that a second messenger pathway can be mediated by a G protein system since IL-4 concomitantly induces class II and p21ras expression which can be successfully blocked by a highly specific anti-p21ras monoclonal antibody.	Tetradecanoylphorbol Acetate	194-197	HRas proto-oncogene, GTPase	Homo sapiens	378-384
1377987-5	1992	In addition, the pyruvate kinase C (PKC) pathway does not seem to participate in the process either because in our system activation of PKC by 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) is insufficient by itself to induce HLA-DR. We found, however, that a second messenger pathway can be mediated by a G protein system since IL-4 concomitantly induces class II and p21ras expression which can be successfully blocked by a highly specific anti-p21ras monoclonal antibody.	Tetradecanoylphorbol Acetate	194-197	HRas proto-oncogene, GTPase	Homo sapiens	456-462
1622389-5	1992	Down-regulation of protein kinase C-alpha by prolonged treatment with phorbol esters eliminated the ability of phorbol 12-myristate 13-acetate, dioctanoylglycerol, thrombin and histamine to phosphorylate HSP27 above background levels and deceased interleukin-1-stimulated HSP27 phosphorylation by 60%.	Tetradecanoylphorbol Acetate	111-142	heat shock protein family B (small) member 1	Homo sapiens	204-209
1622389-5	1992	Down-regulation of protein kinase C-alpha by prolonged treatment with phorbol esters eliminated the ability of phorbol 12-myristate 13-acetate, dioctanoylglycerol, thrombin and histamine to phosphorylate HSP27 above background levels and deceased interleukin-1-stimulated HSP27 phosphorylation by 60%.	Tetradecanoylphorbol Acetate	111-142	heat shock protein family B (small) member 1	Homo sapiens	272-277
1350288-6	1992	In contrast, CD4+ T cells from infected mice could be induced to proliferate by stimulation with PMA and ionomycin resulting in IL-2R up-regulation, IL-2 production, and proliferation.	Tetradecanoylphorbol Acetate	97-100	interleukin 2	Mus musculus	128-132
1596871-1	1992	Anthralin, iodoacetic acid, BHT, Tween 60 and TPA induced cytoplasmic accumulation of transcripts of the proliferin gene family at or near effective concentrations for promotion of morphological transformation of C3H/10T1/2 cells.	Tetradecanoylphorbol Acetate	46-49	prolactin family 2, subfamily c, member 2	Mus musculus	105-115
1533323-8	1992	However, this phenomenon was not specific for LPS; 1 microgram/mL IL-1ra inhibited IL-1 beta synthesized in response to human recombinant IL-2 by 44% (P less than .001), toxic shock syndrome toxin-1 by 26% (P less than .05), and phorbol 12-myristate 13-acetate by 76% (P less than .001).	Tetradecanoylphorbol Acetate	229-260	interleukin 1 receptor antagonist	Homo sapiens	66-72
33162030-7	2021	Interleukin (IL)-2 production in cultured LPL upon stimulation with phorbol 12-myristate 13-acetate and ionomycin for 24 h was significantly lower in SPF mice than in GF mice.	Tetradecanoylphorbol Acetate	68-99	interleukin 2	Mus musculus	0-18
1373168-7	1992	IL-4 most likely utilizes a protein kinase C-independent signal transduction pathway to modify CD20 molecule inasmuch as staurosporine, an inhibitor of protein kinase C, antagonizes phorbol esters (PMA) but not IL-4-induced CD20 down-regulation.	Tetradecanoylphorbol Acetate	198-201	membrane spanning 4-domains A1	Homo sapiens	95-99
33490254-8	2020	Results: The total average energy expenditure amounted to 1879.5 +- 2352.5 MET-min/week, including LTPA (938.5 +- 1491.9 MET-min/week) and TPA (944.8 +- 1322.4 MET-min/week).	Tetradecanoylphorbol Acetate	100-103	SAFB like transcription modulator	Homo sapiens	121-124
1313028-8	1992	When these experiments were repeated following the co-administration of TPA with TCDD, the levels of TCDD-mediated transcriptional increases in liver Cyp1a-1 and Cyp1a-2 and P450IA1 and P450IA2 mRNAs were dramatically inhibited.	Tetradecanoylphorbol Acetate	72-75	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	150-157
33490254-8	2020	Results: The total average energy expenditure amounted to 1879.5 +- 2352.5 MET-min/week, including LTPA (938.5 +- 1491.9 MET-min/week) and TPA (944.8 +- 1322.4 MET-min/week).	Tetradecanoylphorbol Acetate	100-103	SAFB like transcription modulator	Homo sapiens	121-124
1313028-8	1992	When these experiments were repeated following the co-administration of TPA with TCDD, the levels of TCDD-mediated transcriptional increases in liver Cyp1a-1 and Cyp1a-2 and P450IA1 and P450IA2 mRNAs were dramatically inhibited.	Tetradecanoylphorbol Acetate	72-75	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	162-169
32281291-11	2020	The correlation between RUNX1 and TGF-beta pathway was analyzed in the PMA-induced megakaryocytic differentiating K562 cells, which exhibit mature megakaryocytic features.	Tetradecanoylphorbol Acetate	71-74	RUNX family transcription factor 1	Homo sapiens	24-29
1567363-4	1992	The inhibitors also abrogated the effect of the PKC activator phorbol 12-myristate 13-acetate on PAF-induced [Ca2+]i elevation.	Tetradecanoylphorbol Acetate	62-93	PCNA clamp associated factor	Homo sapiens	97-100
32887693-7	2020	Ubc9-mediated SUMOylated alpha-synuclein avoided PMA-induced lysosomal degradation due to its high solubility.	Tetradecanoylphorbol Acetate	49-52	synuclein, alpha	Mus musculus	25-40
1312452-8	1992	Coincubation for 4 h with PMA caused a decrease in PTH- and forskolin-induced up-regulation of VDR.	Tetradecanoylphorbol Acetate	26-29	vitamin D receptor	Rattus norvegicus	95-98
1544380-8	1992	This contrasted strongly with the effects of TSH, EGF, and TPA on the expression of the thyroglobulin gene, a prominent marker of thyroid cell differentiation: in this case, the regulation was much tighter (high range of stimulation by TSH, strong inhibition by EGF, and suppression of Tg gene expression by TPA) and displayed a great variability of the level of individual cellular response.	Tetradecanoylphorbol Acetate	59-62	thyroglobulin	Canis lupus familiaris	88-101
32705219-8	2020	Moreover, by using western blot analysis, we determined that EA increased the protein expression of the p53 target proteins p21, p53 upregulated modulator of apoptosis (PUMA) [also known as Bcl-2-binding component 3 (BBC3)] and Phorbol-12-myristate-13-acetate-induced protein 1 (NOXA).	Tetradecanoylphorbol Acetate	228-259	H3 histone pseudogene 16	Homo sapiens	124-127
31529243-6	2020	Topical DMBA and TPA application resulted in a significant increase in the protein levels, immunoreactivity, and mRNA expression of HRAS, HIF1alpha, Akt, and PTEN (p &lt; 0.05).	Tetradecanoylphorbol Acetate	17-20	hypoxia inducible factor 1, alpha subunit	Mus musculus	138-147
1544380-8	1992	This contrasted strongly with the effects of TSH, EGF, and TPA on the expression of the thyroglobulin gene, a prominent marker of thyroid cell differentiation: in this case, the regulation was much tighter (high range of stimulation by TSH, strong inhibition by EGF, and suppression of Tg gene expression by TPA) and displayed a great variability of the level of individual cellular response.	Tetradecanoylphorbol Acetate	308-311	thyroglobulin	Canis lupus familiaris	88-101
1560050-1	1992	EL 4-6.1 cells, variants of the murine EL4 thymoma cell line, can be activated by interleukin 1 (IL-1) or phorbol 12-myristate-13-acetate (PMA), or PMA+IL-1 to secrete interleukin 2 (IL-2) and interleukin 4 (IL-4) and to express the IL-2 receptor (IL-2R).	Tetradecanoylphorbol Acetate	139-142	interleukin 2	Mus musculus	168-181
32488129-7	2021	The plasminogen activator tPA was lower in HA-NCI while neuroserpin, the CNS tPA inhibitor, was higher in AD and MCI cortical samples.	Tetradecanoylphorbol Acetate	77-80	serpin family I member 1	Homo sapiens	56-67
1560050-1	1992	EL 4-6.1 cells, variants of the murine EL4 thymoma cell line, can be activated by interleukin 1 (IL-1) or phorbol 12-myristate-13-acetate (PMA), or PMA+IL-1 to secrete interleukin 2 (IL-2) and interleukin 4 (IL-4) and to express the IL-2 receptor (IL-2R).	Tetradecanoylphorbol Acetate	139-142	interleukin 2	Mus musculus	183-187
1560050-1	1992	EL 4-6.1 cells, variants of the murine EL4 thymoma cell line, can be activated by interleukin 1 (IL-1) or phorbol 12-myristate-13-acetate (PMA), or PMA+IL-1 to secrete interleukin 2 (IL-2) and interleukin 4 (IL-4) and to express the IL-2 receptor (IL-2R).	Tetradecanoylphorbol Acetate	139-142	interleukin 4	Mus musculus	193-206
1560050-1	1992	EL 4-6.1 cells, variants of the murine EL4 thymoma cell line, can be activated by interleukin 1 (IL-1) or phorbol 12-myristate-13-acetate (PMA), or PMA+IL-1 to secrete interleukin 2 (IL-2) and interleukin 4 (IL-4) and to express the IL-2 receptor (IL-2R).	Tetradecanoylphorbol Acetate	139-142	interleukin 4	Mus musculus	208-212
32321446-8	2020	Moreover, NCEH1 was upregulated through RORalpha via a phorbol myristate acetate-dependent mechanism during macrophage differentiation from THP1 cells.	Tetradecanoylphorbol Acetate	55-80	neutral cholesterol ester hydrolase 1	Homo sapiens	10-15
1588792-8	1992	In two cases tested high-affinity IL-2R on PMA-treated T-ALL cells could internalize 125I-rIL-2 at 37 degrees C. PMA alone enhanced the spontaneous proliferation of T-ALL cells in three cases, whereas a clear synergy between IL-2 and PMA could be detected in three patients" cells.	Tetradecanoylphorbol Acetate	43-46	interleukin 2	Rattus norvegicus	90-95
32373641-8	2020	After 12 h, PMA-induced ROS production decreased, which was sustained until 48 h. The expressions of inflammation markers (IL1alpha, IL1beta, IL6, IL10, TNFalpha, STAT3, TLR4, MMP9, and HP) and eicosanoids (ALOX5, ALOX5AP, and PLA2G4A) were upregulated.	Tetradecanoylphorbol Acetate	12-15	tumor necrosis factor	Bos taurus	153-161
32373641-8	2020	After 12 h, PMA-induced ROS production decreased, which was sustained until 48 h. The expressions of inflammation markers (IL1alpha, IL1beta, IL6, IL10, TNFalpha, STAT3, TLR4, MMP9, and HP) and eicosanoids (ALOX5, ALOX5AP, and PLA2G4A) were upregulated.	Tetradecanoylphorbol Acetate	12-15	toll like receptor 4	Bos taurus	170-174
3494526-1	1987	Increasing the osmolarity of the culture medium enhances the response of peanut agglutinin (PNA)-negative thymocytes to stimulation by 12-O-tetradecanoylphorbol-13-acetate (TPA), interleukin 1 (IL-1) and interleukin 2 (IL-2) in the presence of phytohemagglutinin (PHA).	Tetradecanoylphorbol Acetate	173-176	interleukin 2	Mus musculus	219-223
1531783-7	1992	Results obtained from mRNA half-life studies demonstrate that the stability of cdc2, cyclin A, cyclin B, and cdc25 transcripts is similar in control and TPA-treated U-937 cells.	Tetradecanoylphorbol Acetate	153-156	cell division cycle 25C	Homo sapiens	109-114
2439327-4	1987	To study the regulation of the murine IL2 gene in T-cell populations of differing stages of maturation, we have used a calcium ionophore in conjunction with the phorbol ester, TPA, to stimulate IL2 gene transcription while bypassing the requirement for triggering through a mature cell surface receptor.	Tetradecanoylphorbol Acetate	176-179	interleukin 2	Mus musculus	194-197
32373641-8	2020	After 12 h, PMA-induced ROS production decreased, which was sustained until 48 h. The expressions of inflammation markers (IL1alpha, IL1beta, IL6, IL10, TNFalpha, STAT3, TLR4, MMP9, and HP) and eicosanoids (ALOX5, ALOX5AP, and PLA2G4A) were upregulated.	Tetradecanoylphorbol Acetate	12-15	phospholipase A2 group IVA	Bos taurus	227-234
1533785-7	1992	After exposure of leukaemic cells to phorbol myristate acetate (PMA), release of M-CSF protein was documented in three of five patients studied.	Tetradecanoylphorbol Acetate	37-62	colony stimulating factor 1	Homo sapiens	81-86
32256797-7	2020	In 293T cells, RbAp48 and TEP decreased tumor necrosis factor-alpha and phorbol 12-myristate 13-acetate-induced activity of LTR.	Tetradecanoylphorbol Acetate	72-103	RB binding protein 4, chromatin remodeling factor	Homo sapiens	15-21
31939617-8	2020	Taken together, these results demonstrated that morin hydrate reduced the metastatic potential in TPA-treated MCF-7 human breast cancer cells via the inhibition of MMPs, uPA and uPAR, and the underlying Akt/GSK-3beta/c-Fos pathway.	Tetradecanoylphorbol Acetate	98-101	plasminogen activator, urokinase receptor	Homo sapiens	178-182
3566738-2	1987	The ecto-kinase reaction of the HLF-cells was cAMP-independent, showed an apparent Km for ATP of 6.99 +/- 0.35 (microM) and was substantially inhibited by TPA and RA.	Tetradecanoylphorbol Acetate	155-158	HLF transcription factor, PAR bZIP family member	Homo sapiens	32-35
3566738-4	1987	In contrast to RA-treatment, however, TPA caused the release of a high molecular weight (approximately 210 kD) phosphoprotein from the HLF.	Tetradecanoylphorbol Acetate	38-41	HLF transcription factor, PAR bZIP family member	Homo sapiens	135-138
3566738-7	1987	The drop in ecto-kinase activity of HLF-cells in situ caused by TPA, RA and the diacylglycerols was accompanied by an increase in total basal-(Mg++-dependent) protein kinase activity present in extracts of treated cells.	Tetradecanoylphorbol Acetate	64-67	HLF transcription factor, PAR bZIP family member	Homo sapiens	36-39
1533785-7	1992	After exposure of leukaemic cells to phorbol myristate acetate (PMA), release of M-CSF protein was documented in three of five patients studied.	Tetradecanoylphorbol Acetate	64-67	colony stimulating factor 1	Homo sapiens	81-86
3102504-7	1987	A 50-fold molar excess of PAI 2 over u-PA is found in both extracts and conditioned media of PMA-treated cells.	Tetradecanoylphorbol Acetate	93-96	serpin family B member 2	Homo sapiens	26-31
1312101-4	1992	However, after AMs were incubated with MBP for 48 hours, again there was a significant reduction observed in both PMA-induced (p = 0.01) and spontaneous (p = 0.002) O2- release compared to that of control cultures.	Tetradecanoylphorbol Acetate	114-117	myelin basic protein	Cavia porcellus	39-42
3102504-8	1987	PAI 2 represents at least 0.3% of total de novo synthesized protein 24 h after induction with PMA.	Tetradecanoylphorbol Acetate	94-97	serpin family B member 2	Homo sapiens	0-5
32238706-9	2020	In vitro stimulation of thymocytes with phorbol myristate acetate (PMA)/ionomycin confirmed the polarization of thymocytes from diet-restricted mice toward Th2 cells.	Tetradecanoylphorbol Acetate	40-65	heart and neural crest derivatives expressed 2	Mus musculus	156-159
32238706-9	2020	In vitro stimulation of thymocytes with phorbol myristate acetate (PMA)/ionomycin confirmed the polarization of thymocytes from diet-restricted mice toward Th2 cells.	Tetradecanoylphorbol Acetate	67-70	heart and neural crest derivatives expressed 2	Mus musculus	156-159
31796994-6	2020	Notably, treatment of cells with ionomycin, a calcium ionophore and a known activator of ADAM10, or with phorbol 12-myristate 13-acetate, an activator of ADAM17, dramatically increases the release of soluble PD-L1 to the media.	Tetradecanoylphorbol Acetate	105-136	CD274 molecule	Homo sapiens	208-213
3098847-6	1987	When added to confluent chondrocytes, phorbol myristate acetate, concanavalin A, IL 2, lipopolysaccharide, indomethacin, and prostaglandin E2, which interfere with lymphocyte proliferation assays for IL 1, failed to influence chondrocyte metalloproteinase secretion.	Tetradecanoylphorbol Acetate	38-63	interleukin 1 alpha	Homo sapiens	200-204
1312101-2	1992	Native MBP at 55 micrograms/ml had an immediate effect (reduction) on phorbol myristate acetate (PMA)-induced (p less than 0.01) and spontaneous (p = 0.055) superoxide (O2-) release by GP AMs.	Tetradecanoylphorbol Acetate	70-95	myelin basic protein	Cavia porcellus	7-10
1312101-2	1992	Native MBP at 55 micrograms/ml had an immediate effect (reduction) on phorbol myristate acetate (PMA)-induced (p less than 0.01) and spontaneous (p = 0.055) superoxide (O2-) release by GP AMs.	Tetradecanoylphorbol Acetate	97-100	myelin basic protein	Cavia porcellus	7-10
31806018-8	2019	Additionally, an increase of IFN-gamma-producing CD4-CD8beta- cells upon H. meleagridis antigen and PMA/ionomycin stimulation was detected.	Tetradecanoylphorbol Acetate	100-103	T-cell surface glycoprotein CD8 alpha chain	Gallus gallus	53-60
1311516-3	1992	Under conditions of partial microvascular recruitment (blood flow = 400 ml/min through the entire lung), PMA, but not the vehicle, significantly reduced substrate utilization of both BPAP and adenosine 5"-monophosphate (AMP) and increased the apparent Michaelis constant (Km) values of ACE for BPAP, indicative of metabolic dysfunction.	Tetradecanoylphorbol Acetate	105-108	angiotensin-converting enzyme	Oryctolagus cuniculus	286-289
1733720-9	1992	Addition of ionomycin or 12-O-tetradecanoyl-phorbol-13-acetate separately to acidified cells had only modest effects on pHi; however, addition of 12-O-tetradecanoyl-phorbol-13-acetate and ionomycin together increased pHi markedly.	Tetradecanoylphorbol Acetate	25-62	glucose-6-phosphate isomerase	Rattus norvegicus	120-123
31728037-5	2019	Here we report that in HeLa cells, activation of protein kinase C by phorbol 12-myristate 13-acetate (PMA) triggers efficient endocytosis and degradation of LAT1.	Tetradecanoylphorbol Acetate	69-100	solute carrier family 7 member 5	Homo sapiens	157-161
3026676-2	1987	Both pro-1 and pro-2 homologs were identified by screening this library with mouse probes, but only the pro-1 homologs were able to confer sensitivity to TPA-induced transformation when transferred to promotion-insensitive mouse JB6 cells.	Tetradecanoylphorbol Acetate	154-157	proline dehydrogenase	Mus musculus	5-10
3026676-2	1987	Both pro-1 and pro-2 homologs were identified by screening this library with mouse probes, but only the pro-1 homologs were able to confer sensitivity to TPA-induced transformation when transferred to promotion-insensitive mouse JB6 cells.	Tetradecanoylphorbol Acetate	154-157	proline dehydrogenase	Mus musculus	104-109
31728037-5	2019	Here we report that in HeLa cells, activation of protein kinase C by phorbol 12-myristate 13-acetate (PMA) triggers efficient endocytosis and degradation of LAT1.	Tetradecanoylphorbol Acetate	102-105	solute carrier family 7 member 5	Homo sapiens	157-161
1352781-3	1992	TPA, SB and dbcAMP behave as "early" inducers, in the sense that vimentin mRNA levels are rapidly increased (hour 6) upon drug administration.	Tetradecanoylphorbol Acetate	0-3	vimentin	Homo sapiens	65-73
31728037-8	2019	By systematically mutagenizing the residues of the LAT1 cytosolic tails, we identified a group of three close lysines (K19, K25, K30) in the N-terminal tail that are important for PMA-induced ubiquitylation and downregulation.	Tetradecanoylphorbol Acetate	180-183	solute carrier family 7 member 5	Homo sapiens	51-55
2448177-9	1987	Continuous treatment of adult tail or ear epidermis with hyperplasiogenic agents, e.g., vitamin A acid and the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), leads to a gradual disappearance of the 70-kDa protein.	Tetradecanoylphorbol Acetate	127-163	heat shock protein, pseudogene 1	Mus musculus	211-217
3311846-4	1987	Decrease in antigen-positive cells is delayed in LPS/TNF versus IL-1-alpha, beta/TPA-induced antigen expression (LPS vs. IL-1-beta: 60% vs. 5% at 24 h).	Tetradecanoylphorbol Acetate	81-84	interleukin 1 alpha	Homo sapiens	64-74
1352781-7	1992	Moreover, RA is capable of delaying the early induction of vimentin expression caused by TPA and SB, without affecting the normal expression of differentiation markers.	Tetradecanoylphorbol Acetate	89-92	vimentin	Homo sapiens	59-67
3311846-4	1987	Decrease in antigen-positive cells is delayed in LPS/TNF versus IL-1-alpha, beta/TPA-induced antigen expression (LPS vs. IL-1-beta: 60% vs. 5% at 24 h).	Tetradecanoylphorbol Acetate	81-84	interferon regulatory factor 6	Homo sapiens	113-116
1549353-3	1992	The smg p21 protein molecules also increased during the TPA-induced differentiation of CMK cells.	Tetradecanoylphorbol Acetate	56-59	H3 histone pseudogene 16	Homo sapiens	8-11
3609441-0	1987	Ornithine decarboxylase activity in foetal rat brain cells and in the mouse embryo fibroblasts C3H/10T1/2 CL8 cells: differences in response to medium change and to the tumor promoter TPA.	Tetradecanoylphorbol Acetate	184-187	ornithine decarboxylase 1	Rattus norvegicus	0-23
1549353-5	1992	Ha-ras p21 mRNA was undetectable, but both Ki- and N-ras p21 mRNAs were detected in CMK cells and their levels were also increased during TPA-induced differentiation of CMK cells, although to a lesser extent than those of smg p21 mRNAs.	Tetradecanoylphorbol Acetate	138-141	H3 histone pseudogene 16	Homo sapiens	7-10
1549353-5	1992	Ha-ras p21 mRNA was undetectable, but both Ki- and N-ras p21 mRNAs were detected in CMK cells and their levels were also increased during TPA-induced differentiation of CMK cells, although to a lesser extent than those of smg p21 mRNAs.	Tetradecanoylphorbol Acetate	138-141	H3 histone pseudogene 16	Homo sapiens	57-60
1549353-5	1992	Ha-ras p21 mRNA was undetectable, but both Ki- and N-ras p21 mRNAs were detected in CMK cells and their levels were also increased during TPA-induced differentiation of CMK cells, although to a lesser extent than those of smg p21 mRNAs.	Tetradecanoylphorbol Acetate	138-141	H3 histone pseudogene 16	Homo sapiens	57-60
3325885-2	1987	However, an early (0.5-8.0 h post-induction) transient reduction of c- and N-myc transcripts were observed in these cells upon induction to differentiation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	179-215	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	75-80
3325885-2	1987	However, an early (0.5-8.0 h post-induction) transient reduction of c- and N-myc transcripts were observed in these cells upon induction to differentiation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	217-220	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	75-80
1549353-9	1992	A dramatic increase in the smg p21 mRNA levels was also observed in other leukemia cell lines during TPA-induced differentiation.	Tetradecanoylphorbol Acetate	101-104	H3 histone pseudogene 16	Homo sapiens	31-34
3325885-9	1987	Thus, the TPA-induced neuronal differentiation of SH-SY5Y cells was compatible with high c-fos and a substantial N-myc mRNA expression.	Tetradecanoylphorbol Acetate	10-13	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	113-118
1738590-4	1992	Induction of jun B can be mimicked in wild type P19 EC cells by the synergistic action of the phorbol ester TPA and the calcium ionophore A23187, through activation of signal transduction pathways, that are activated simultaneously by EGF.	Tetradecanoylphorbol Acetate	108-111	epidermal growth factor	Homo sapiens	235-238
1730605-3	1992	Nuclear extracts from cells stimulated with phorbol 12-myristate 13-acetate and ionomycin, which activate protein kinase C and mimic physiological activation through the T-cell antigen receptor, transcribe an interleukin-2 (IL-2) enhancer (-326 to +24) template 5-fold more efficient than nuclear extracts from resting T-cells and severalfold more efficient than extracts from Jurkat cells treated with phorbol 12-myristate 13-acetate or ionomycin alone.	Tetradecanoylphorbol Acetate	44-75	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	170-193
3025854-8	1987	In addition, we found that only the more mature cells can undergo prolonged phorbol 12-myristate 13-acetate-induced growth arrest, suggesting that the maintenance of these leukemic cells in their proliferative state, presumably by the myb gene product, can be overcome with appropriate differentiation signal(s).	Tetradecanoylphorbol Acetate	76-107	myeloblastosis oncogene	Mus musculus	235-238
3100060-5	1986	TPA strongly synergized with ionomycin both for Il-2 secretion and for Il-2 receptor expression whereas Il-1 did not.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Mus musculus	48-52
3100060-5	1986	TPA strongly synergized with ionomycin both for Il-2 secretion and for Il-2 receptor expression whereas Il-1 did not.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Mus musculus	71-75
3100060-7	1986	However, on EL4 cells which were also partially responsive to TPA alone, Il-1 showed strong synergy with TPA to induce Il-2 secretion and Il-2 receptor expression.	Tetradecanoylphorbol Acetate	105-108	interleukin 2	Mus musculus	119-123
1730605-3	1992	Nuclear extracts from cells stimulated with phorbol 12-myristate 13-acetate and ionomycin, which activate protein kinase C and mimic physiological activation through the T-cell antigen receptor, transcribe an interleukin-2 (IL-2) enhancer (-326 to +24) template 5-fold more efficient than nuclear extracts from resting T-cells and severalfold more efficient than extracts from Jurkat cells treated with phorbol 12-myristate 13-acetate or ionomycin alone.	Tetradecanoylphorbol Acetate	403-434	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	170-193
1311145-5	1992	EPO stimulated the incorporation of 3H-leucine into TPA-treated L8057 cells, and the maximal effect of EPO was observed at the same order as the Kd value of high affinity sites.	Tetradecanoylphorbol Acetate	52-55	erythropoietin	Mus musculus	0-3
3100060-7	1986	However, on EL4 cells which were also partially responsive to TPA alone, Il-1 showed strong synergy with TPA to induce Il-2 secretion and Il-2 receptor expression.	Tetradecanoylphorbol Acetate	105-108	interleukin 2	Mus musculus	138-142
3100060-8	1986	The effect of Il-1 on EL4 cells was dose dependent where increasingly higher concentrations of Il-1 in the presence of a fixed concentration of TPA caused higher percentage of EL4 cells to become Il-2 receptor positive.	Tetradecanoylphorbol Acetate	144-147	interleukin 2	Mus musculus	196-200
1311145-5	1992	EPO stimulated the incorporation of 3H-leucine into TPA-treated L8057 cells, and the maximal effect of EPO was observed at the same order as the Kd value of high affinity sites.	Tetradecanoylphorbol Acetate	52-55	erythropoietin	Mus musculus	103-106
1571204-9	1992	Prolonged exposure (48 h) to PMA (0.1-10 nM) enhanced DNA synthesis of MOB 3-4-F2 cells, but not MOB 3-4 cells.	Tetradecanoylphorbol Acetate	29-32	MOB family member 4, phocein	Homo sapiens	71-76
1599878-5	1992	Treatment of HOS cells with tumor promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, results in repression of smooth muscle MLC-2 mRNA.	Tetradecanoylphorbol Acetate	59-95	myosin light chain 2	Homo sapiens	136-141
2879753-1	1986	Incubation of cultured ovine pituitary cells with the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA) (0.1-100 nM), caused a dose-related stimulation of both growth hormone (ED50 approximately 4 nM) and prolactin (ED50 approximately 14 nM) secretion.	Tetradecanoylphorbol Acetate	85-121	prolactin	Ovis aries	229-238
2879753-1	1986	Incubation of cultured ovine pituitary cells with the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA) (0.1-100 nM), caused a dose-related stimulation of both growth hormone (ED50 approximately 4 nM) and prolactin (ED50 approximately 14 nM) secretion.	Tetradecanoylphorbol Acetate	123-126	prolactin	Ovis aries	229-238
2879753-2	1986	Stimulation by TPA (100 nM) produced a substantial 10-fold increase in growth hormone with a smaller, 2-fold rise in prolactin secretion over 30 min; significant effects on the release of both hormones occurred within 2 min.	Tetradecanoylphorbol Acetate	15-18	prolactin	Ovis aries	117-126
2879753-5	1986	In the presence of TPA (10 nM), dopamine (1-1000 nM) suppressed prolactin secretion to a level close to that observed for maximal inhibition of unstimulated cells.	Tetradecanoylphorbol Acetate	19-22	prolactin	Ovis aries	64-73
2879753-7	1986	Somatostatin (0.01-1.0 microM) completely inhibited the substantial (approximately 9-fold) TPA-induced stimulation of growth hormone secretion (inhibitory ED50 approximately 47 nM), and also suppressed TPA-stimulated prolactin secretion to the control level.	Tetradecanoylphorbol Acetate	91-94	prolactin	Ovis aries	217-226
2879753-7	1986	Somatostatin (0.01-1.0 microM) completely inhibited the substantial (approximately 9-fold) TPA-induced stimulation of growth hormone secretion (inhibitory ED50 approximately 47 nM), and also suppressed TPA-stimulated prolactin secretion to the control level.	Tetradecanoylphorbol Acetate	202-205	prolactin	Ovis aries	217-226
1599878-9	1992	Quantitative analysis of MLC-2 isoforms in different HOS cells indicates that the synthesis of smooth muscle MLC-2 isoform is specifically repressed to an undetectable level in ras transformed and MNNG transformed cells and also following treatment with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	254-290	myosin light chain 2	Homo sapiens	109-114
1591384-6	1992	Furthermore, interleukin-4 fully inhibited the DNA fragmentation induced by the protein kinase-C activator 12-O-tetradecanoylphorbol-13-acetate, but was ineffective against apoptosis induced by the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	107-143	interleukin 4	Mus musculus	13-26
2430281-2	1986	We show that, when A31 cells were subconfluent and made quiescent by serum deprivation, the phorbol ester phorbol 12-myristate 13-acetate induced c-fos and c-myc mRNA poorly, whereas EGF was a better inducer.	Tetradecanoylphorbol Acetate	106-137	FBJ osteosarcoma oncogene	Mus musculus	146-151
1379817-4	1992	Exposure of quiescent Mel-ab cells to the PKC-activating phorbol esters TPA or sapintoxin A at 81 nM for 2 h increased levels of mRNA for six of seven TIS genes examined (twofold to 80-fold increase in steady-state RNA levels for TIS 1, 7, 8, 11, 21, and 28 (c-fos); TIS 10 expression was not affected).	Tetradecanoylphorbol Acetate	72-75	nuclear receptor subfamily 4, group A, member 1	Mus musculus	230-235
3464595-1	1986	Treatment of HL-60 promyelocytic leukemia cells with the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), causes rapid phosphorylation and dephosphorylation of pp17, a 17-20-kDa, pI 5.5 cytosolic protein, as an early event in a response sequence leading to growth arrest and terminal differentiation into monocytes (Feuerstein, N., and Cooper, H. L., (1984) J. Biol.	Tetradecanoylphorbol Acetate	126-129	stathmin 1	Homo sapiens	186-190
3464595-9	1986	Upon TPA treatment, pre-existing p17 was rapidly phosphorylated to pp17.	Tetradecanoylphorbol Acetate	5-8	stathmin 1	Homo sapiens	67-71
3464595-13	1986	Quantitatively, therefore, the phosphorylation of p17 to pp17 is one of the most prominent early biochemical responses to TPA treatment.	Tetradecanoylphorbol Acetate	122-125	stathmin 1	Homo sapiens	57-61
1379817-4	1992	Exposure of quiescent Mel-ab cells to the PKC-activating phorbol esters TPA or sapintoxin A at 81 nM for 2 h increased levels of mRNA for six of seven TIS genes examined (twofold to 80-fold increase in steady-state RNA levels for TIS 1, 7, 8, 11, 21, and 28 (c-fos); TIS 10 expression was not affected).	Tetradecanoylphorbol Acetate	72-75	FBJ osteosarcoma oncogene	Mus musculus	259-264
3464595-14	1986	Available data indicate that p17 predominates in rapidly proliferating cells, while phosphorylation to pp17 occurs where cell growth is modified by TPA or other agents.	Tetradecanoylphorbol Acetate	148-151	stathmin 1	Homo sapiens	103-107
1755845-3	1991	Both thrombin and phorbol-12-myristate-13-acetate (PMA) induced mRNA for the c-myc oncogene; peak levels of expression were found 4-5 h after exposure to either agent.	Tetradecanoylphorbol Acetate	18-49	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	77-82
1755845-3	1991	Both thrombin and phorbol-12-myristate-13-acetate (PMA) induced mRNA for the c-myc oncogene; peak levels of expression were found 4-5 h after exposure to either agent.	Tetradecanoylphorbol Acetate	51-54	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	77-82
3096619-11	1986	In addition, the data suggest distinct, but co-operative pathways of IL-2 receptor induction, controlled by elevated Ca2+ alone and by protein kinase C. Subsequent intracellular events of T cell activation by A23187/PMA may be quite similar to those triggered by Con A, since both kinds of stimulation are blocked by agents such as cyclosporin A, dbcAMP and K+ channel blockers.	Tetradecanoylphorbol Acetate	216-219	interleukin 2	Mus musculus	69-73
1744120-5	1991	When protein kinase C in the bovine aortic endothelial cells was down-regulated by preincubation with 8 x 10(-7) M PMA for 24 or 48 h, insulin was still able to increase ET-1 mRNA levels whereas PMA was ineffective.	Tetradecanoylphorbol Acetate	115-118	insulin	Bos taurus	135-142
1665062-1	1991	The production of the precursor of tissue collagenase/matrix metalloproteinase 1 (proMMP-1) by cultured human aortic medial smooth muscle cells (SMCs) was significantly enhanced by the treatment of the cells with platelet-derived growth factor (PDGF), interleukin 1 or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	269-305	matrix metallopeptidase 1	Homo sapiens	54-80
3091685-3	1986	The expression of rat IL 2R on those hybrid cells could be up-regulated by IL 2 itself, ATL-derived factor, and TPA and CA++ ionophore.	Tetradecanoylphorbol Acetate	112-115	interleukin 2	Rattus norvegicus	22-26
1668119-4	1991	Preincubation with a small amount of PAF (5 x 10(-9) M) enhanced PMN superoxide release induced by various stimuli, such as phorbol myristate acetate (PMA), opsonized zymosan (OZ), calcium ionophore (A23187) and N-formyl-methionyl-leucyl-phenylalanine (FMLP).	Tetradecanoylphorbol Acetate	124-149	PCNA clamp associated factor	Homo sapiens	37-40
3090144-5	1986	In the presence of either suboptimal levels of phorbol ester (PMA) or Ionomycin, the addition of IL 1 resulted in up to an 80-fold enhancement in the amount of IL 2 secreted.	Tetradecanoylphorbol Acetate	62-65	interleukin 2	Mus musculus	160-164
3093404-4	1986	TPA enhanced PRL-stimulated Nb2 node lymphoma cell ornithine decarboxylase induction and [3H]thymidine incorporation.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase 1	Rattus norvegicus	51-74
1668119-4	1991	Preincubation with a small amount of PAF (5 x 10(-9) M) enhanced PMN superoxide release induced by various stimuli, such as phorbol myristate acetate (PMA), opsonized zymosan (OZ), calcium ionophore (A23187) and N-formyl-methionyl-leucyl-phenylalanine (FMLP).	Tetradecanoylphorbol Acetate	151-154	PCNA clamp associated factor	Homo sapiens	37-40
3087969-3	1986	We show that the plant lectin concanavalin A (ConA), the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) and the Ca2+-ionophore A23187 each causes a rapid increase in both c-fos and c-myc mRNAs.	Tetradecanoylphorbol Acetate	71-108	FBJ osteosarcoma oncogene	Mus musculus	182-187
1774959-9	1991	In addition, TPA mediated expression of the transfected c-myc gene in FDMT myc.A1 was accompanied by augmented transcription of c-jun and c-fos in response to TPA.	Tetradecanoylphorbol Acetate	13-16	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	56-61
1774959-4	1991	On the other hand, the protein kinase C agonist, TPA, strongly activated c-jun expression but poorly promoted expression (transcription) of c-myc in FDC-P1.	Tetradecanoylphorbol Acetate	49-52	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	140-145
3009147-3	1986	Activation of protein kinase C with phorbol 12-myristate 13-acetate (PMA) results 2 h later in an amplification of LHRH-induced LH secretion in a concentration (1 nM to 1 microM)-and protein synthesis-dependent manner in proestrous, but not estrous, pituitaries; the diacylglycerol analog 1-oleoyl-2-acetylglycerol (OAG) also augments subsequent LHRH-induced secretion.	Tetradecanoylphorbol Acetate	36-67	gonadotropin releasing hormone 1	Rattus norvegicus	115-119
1774959-6	1991	However, stable transfection of FDC-P1 with a c-myc expression vector driven by a human methallothionein IIA promoter containing the TPA responsive element (TRE), led to a cell clone, FDMT myc.A1, in which TPA mediated selective transcription of the transfected TRE driven c-myc vector and down-regulated expression of the endogenous c-myc gene.	Tetradecanoylphorbol Acetate	133-136	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	46-51
3009147-3	1986	Activation of protein kinase C with phorbol 12-myristate 13-acetate (PMA) results 2 h later in an amplification of LHRH-induced LH secretion in a concentration (1 nM to 1 microM)-and protein synthesis-dependent manner in proestrous, but not estrous, pituitaries; the diacylglycerol analog 1-oleoyl-2-acetylglycerol (OAG) also augments subsequent LHRH-induced secretion.	Tetradecanoylphorbol Acetate	36-67	gonadotropin releasing hormone 1	Rattus norvegicus	346-350
1823929-6	1991	A tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) decreased tyrosinase mRNA level at 30 nM concentration.	Tetradecanoylphorbol Acetate	18-55	tyrosinase	Mus musculus	72-82
3009147-3	1986	Activation of protein kinase C with phorbol 12-myristate 13-acetate (PMA) results 2 h later in an amplification of LHRH-induced LH secretion in a concentration (1 nM to 1 microM)-and protein synthesis-dependent manner in proestrous, but not estrous, pituitaries; the diacylglycerol analog 1-oleoyl-2-acetylglycerol (OAG) also augments subsequent LHRH-induced secretion.	Tetradecanoylphorbol Acetate	69-72	gonadotropin releasing hormone 1	Rattus norvegicus	115-119
3009147-3	1986	Activation of protein kinase C with phorbol 12-myristate 13-acetate (PMA) results 2 h later in an amplification of LHRH-induced LH secretion in a concentration (1 nM to 1 microM)-and protein synthesis-dependent manner in proestrous, but not estrous, pituitaries; the diacylglycerol analog 1-oleoyl-2-acetylglycerol (OAG) also augments subsequent LHRH-induced secretion.	Tetradecanoylphorbol Acetate	69-72	gonadotropin releasing hormone 1	Rattus norvegicus	346-350
3009492-6	1986	Concomitantly, the binding of IGF-II disappeared almost totally, which offers a possible explanation for the reduced biological response to IGF-II after TPA treatment.	Tetradecanoylphorbol Acetate	153-156	insulin like growth factor 2	Homo sapiens	30-36
1823929-6	1991	A tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) decreased tyrosinase mRNA level at 30 nM concentration.	Tetradecanoylphorbol Acetate	57-60	tyrosinase	Mus musculus	72-82
3009492-6	1986	Concomitantly, the binding of IGF-II disappeared almost totally, which offers a possible explanation for the reduced biological response to IGF-II after TPA treatment.	Tetradecanoylphorbol Acetate	153-156	insulin like growth factor 2	Homo sapiens	140-146
1823929-7	1991	Dexamethasone antagonized this TPA-mediated decrease in tyrosinase mRNA.	Tetradecanoylphorbol Acetate	31-34	tyrosinase	Mus musculus	56-66
1779468-9	1991	These findings suggest that smg p21s play an important role during the TPA-induced differentiation of CMK cells.	Tetradecanoylphorbol Acetate	71-74	H3 histone pseudogene 16	Homo sapiens	32-35
3005278-4	1986	The effect of IL 2 on CT6 cell proliferation and cAMP production was mimicked by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), which, like IL 2, causes a translocation and activation of protein kinase C. While PGE2 stimulated adenylate cyclase activity in membrane preparations, neither IL 2 nor TPA inhibited either basal or stimulated membrane adenylate cyclase activity.	Tetradecanoylphorbol Acetate	137-140	interleukin 2	Mus musculus	14-18
3005278-4	1986	The effect of IL 2 on CT6 cell proliferation and cAMP production was mimicked by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), which, like IL 2, causes a translocation and activation of protein kinase C. While PGE2 stimulated adenylate cyclase activity in membrane preparations, neither IL 2 nor TPA inhibited either basal or stimulated membrane adenylate cyclase activity.	Tetradecanoylphorbol Acetate	137-140	interleukin 2	Mus musculus	155-159
3005278-4	1986	The effect of IL 2 on CT6 cell proliferation and cAMP production was mimicked by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), which, like IL 2, causes a translocation and activation of protein kinase C. While PGE2 stimulated adenylate cyclase activity in membrane preparations, neither IL 2 nor TPA inhibited either basal or stimulated membrane adenylate cyclase activity.	Tetradecanoylphorbol Acetate	137-140	interleukin 2	Mus musculus	155-159
3005278-4	1986	The effect of IL 2 on CT6 cell proliferation and cAMP production was mimicked by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), which, like IL 2, causes a translocation and activation of protein kinase C. While PGE2 stimulated adenylate cyclase activity in membrane preparations, neither IL 2 nor TPA inhibited either basal or stimulated membrane adenylate cyclase activity.	Tetradecanoylphorbol Acetate	312-315	interleukin 2	Mus musculus	14-18
3005278-4	1986	The effect of IL 2 on CT6 cell proliferation and cAMP production was mimicked by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), which, like IL 2, causes a translocation and activation of protein kinase C. While PGE2 stimulated adenylate cyclase activity in membrane preparations, neither IL 2 nor TPA inhibited either basal or stimulated membrane adenylate cyclase activity.	Tetradecanoylphorbol Acetate	312-315	interleukin 2	Mus musculus	155-159
1946468-3	1991	Here we show that the PMA-induced differentiation of SH-SY5Y cells grown in a serum-free medium is strongly potentiated by nanomolar concentrations of IGF-I, as judged by morphology and markers for neuronal differentiation--e.g., neuropeptide tyrosine and growth-associated protein 43.	Tetradecanoylphorbol Acetate	22-25	growth associated protein 43	Homo sapiens	256-284
3005278-4	1986	The effect of IL 2 on CT6 cell proliferation and cAMP production was mimicked by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), which, like IL 2, causes a translocation and activation of protein kinase C. While PGE2 stimulated adenylate cyclase activity in membrane preparations, neither IL 2 nor TPA inhibited either basal or stimulated membrane adenylate cyclase activity.	Tetradecanoylphorbol Acetate	312-315	interleukin 2	Mus musculus	155-159
1718584-7	1991	TPA-induced expression of the c-fos gene was used as an additional marker for intracellular PKC activity.	Tetradecanoylphorbol Acetate	0-3	FBJ osteosarcoma oncogene	Mus musculus	30-35
3002990-1	1986	Two putative genes (termed pro 1 and pro 2) specifying sensitivity to induction of neoplastic transformation by TPA in mouse epidermal JB6 cells were cloned by sib selection from a size-selected genomic library of clonal cells sensitive to promotion of transformation.	Tetradecanoylphorbol Acetate	112-115	proline dehydrogenase	Mus musculus	27-32
1953649-2	1991	Phorbol 12-myristate 13-acetate (PMA) stimulated 15-PGDH activity in a time- and concentration-dependent manner.	Tetradecanoylphorbol Acetate	0-31	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	49-56
3000588-1	1986	12-O-Tetradecanoylphorbol-13-acetate (TPA) and 4 beta-phorbol 12, 13-dibutyrate (PDBU) are potent tumor promoters and share several biological activities of epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	0-36	epidermal growth factor	Canis lupus familiaris	157-180
3000588-1	1986	12-O-Tetradecanoylphorbol-13-acetate (TPA) and 4 beta-phorbol 12, 13-dibutyrate (PDBU) are potent tumor promoters and share several biological activities of epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	0-36	epidermal growth factor	Canis lupus familiaris	182-185
1953649-2	1991	Phorbol 12-myristate 13-acetate (PMA) stimulated 15-PGDH activity in a time- and concentration-dependent manner.	Tetradecanoylphorbol Acetate	33-36	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	49-56
3000588-1	1986	12-O-Tetradecanoylphorbol-13-acetate (TPA) and 4 beta-phorbol 12, 13-dibutyrate (PDBU) are potent tumor promoters and share several biological activities of epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	38-41	epidermal growth factor	Canis lupus familiaris	157-180
1953649-7	1991	Stimulation of 15-PGDH activity by PMA or DMSO appears to be mediated by protein kinase C activation, since an inactive analogue of PMA failed to induce the effect, and both staurosporine and H-7 blocked the stimulation.	Tetradecanoylphorbol Acetate	35-38	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	15-22
3000588-1	1986	12-O-Tetradecanoylphorbol-13-acetate (TPA) and 4 beta-phorbol 12, 13-dibutyrate (PDBU) are potent tumor promoters and share several biological activities of epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	38-41	epidermal growth factor	Canis lupus familiaris	182-185
1655771-1	1991	We have used an interleukin-2 (IL-2) promoter-CAT fusion gene to study activation of IL-2 gene expression by IL-1, phytohemagglutinin (PHA), phorbol myristate acetate (PMA), and calcium ionophore in the murine thymoma line EL4 and the human lymphoma line Jurkat.	Tetradecanoylphorbol Acetate	141-166	interleukin 2	Mus musculus	85-89
1655771-1	1991	We have used an interleukin-2 (IL-2) promoter-CAT fusion gene to study activation of IL-2 gene expression by IL-1, phytohemagglutinin (PHA), phorbol myristate acetate (PMA), and calcium ionophore in the murine thymoma line EL4 and the human lymphoma line Jurkat.	Tetradecanoylphorbol Acetate	168-171	interleukin 2	Mus musculus	16-29
3948318-1	1986	The effect of a single treatment with the skin tumor-promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of the cellular proto-oncogenes, c-myc, c-rasHa, c-rasKi and c-fos was examined in the non-tumorigenic human bladder epithelial cell line HCV 29.	Tetradecanoylphorbol Acetate	62-98	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	156-161
1655771-1	1991	We have used an interleukin-2 (IL-2) promoter-CAT fusion gene to study activation of IL-2 gene expression by IL-1, phytohemagglutinin (PHA), phorbol myristate acetate (PMA), and calcium ionophore in the murine thymoma line EL4 and the human lymphoma line Jurkat.	Tetradecanoylphorbol Acetate	168-171	interleukin 2	Mus musculus	85-89
1915380-9	1991	In cells pretreated with 12-O-tetradecanoylphorbol 13-acetate, however, in which protein kinase was supposed to be downregulated, H2O2 induced c-fos and heme oxygenase as efficiently as in untreated cells.	Tetradecanoylphorbol Acetate	25-61	FBJ osteosarcoma oncogene	Mus musculus	143-148
3762216-5	1986	Phosphorylation of various cell lysate proteins (p18, p21, p29, p34 and p45) were also stimulated by TPA.	Tetradecanoylphorbol Acetate	101-104	SYF2 homolog, RNA splicing factor (S. cerevisiae)	Mus musculus	59-62
31434734-5	2019	However, following treatment with phorbol 12-myristate 13-acetate (PMA), ASP translocates to the cytoplasm and is detectable on the cell surface, even in the absence of membrane permeabilization, indicating that 324.6 recognizes an ASP epitope that is exposed extracellularly.	Tetradecanoylphorbol Acetate	34-65	assembly factor for spindle microtubules	Homo sapiens	73-76
31434734-5	2019	However, following treatment with phorbol 12-myristate 13-acetate (PMA), ASP translocates to the cytoplasm and is detectable on the cell surface, even in the absence of membrane permeabilization, indicating that 324.6 recognizes an ASP epitope that is exposed extracellularly.	Tetradecanoylphorbol Acetate	34-65	assembly factor for spindle microtubules	Homo sapiens	232-235
31434734-5	2019	However, following treatment with phorbol 12-myristate 13-acetate (PMA), ASP translocates to the cytoplasm and is detectable on the cell surface, even in the absence of membrane permeabilization, indicating that 324.6 recognizes an ASP epitope that is exposed extracellularly.	Tetradecanoylphorbol Acetate	67-70	assembly factor for spindle microtubules	Homo sapiens	73-76
31434734-5	2019	However, following treatment with phorbol 12-myristate 13-acetate (PMA), ASP translocates to the cytoplasm and is detectable on the cell surface, even in the absence of membrane permeabilization, indicating that 324.6 recognizes an ASP epitope that is exposed extracellularly.	Tetradecanoylphorbol Acetate	67-70	assembly factor for spindle microtubules	Homo sapiens	232-235
31434734-9	2019	Our studies indicate that ASP is an integral protein of the plasma membranes of chronically infected cells stimulated with PMA, and upon viral budding, ASP becomes a structural protein of the HIV-1 envelope.	Tetradecanoylphorbol Acetate	123-126	assembly factor for spindle microtubules	Homo sapiens	26-29
31434734-13	2019	In addition, we show that after PMA treatment, ASP exits the nucleus and localizes on the cell membrane.	Tetradecanoylphorbol Acetate	32-35	assembly factor for spindle microtubules	Homo sapiens	47-50
2867449-1	1985	Since prolactin, like the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate, induces ornithine decarboxylase and plasminogen activator activities, biochemical markers of a trophic response, this hormone might likewise promote neoplasia.	Tetradecanoylphorbol Acetate	41-78	ornithine decarboxylase 1	Rattus norvegicus	88-111
1663531-3	1991	Both rIFN-beta ser and rIFN-gamma increased phorbol myristate acetate-stimulated superoxide anion generation by AM in a dose-dependent fashion.	Tetradecanoylphorbol Acetate	44-69	interferon beta 1	Rattus norvegicus	5-14
31379722-9	2019	Based on research findings from in vitro, animal, and clinical studies, we propose that ADAMTS13 is a potential biomarker to guide appropriate treatment for ischemic stroke and a promising therapeutic agent for tPA resistant thrombi.	Tetradecanoylphorbol Acetate	211-214	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	88-96
2866188-7	1985	The tumor promoter, 4 beta-phorbol 12-myristate 13-acetate, appears to mimic the action of EGF in inducing EGF-R accumulation in coated pits at the cell surface and receptor internalization.	Tetradecanoylphorbol Acetate	22-58	epidermal growth factor	Homo sapiens	107-112
1663531-3	1991	Both rIFN-beta ser and rIFN-gamma increased phorbol myristate acetate-stimulated superoxide anion generation by AM in a dose-dependent fashion.	Tetradecanoylphorbol Acetate	44-69	interferon gamma	Rattus norvegicus	23-33
1745018-7	1991	ODC activity with similar kinetics but lower peak levels was also induced by incubating MCs with mitogens, such as platelet-derived growth factor (PDGF-AB 20 ng/ml), arginine vasopressin (AVP 10(-7) M), phorbol myristate acetate (PMA 10(-7) M), interleukin 1 alpha and beta (IL-1 alpha 10 U/ml, IL-1 beta 10 U/ml).	Tetradecanoylphorbol Acetate	203-228	ornithine decarboxylase 1	Rattus norvegicus	0-3
3933820-3	1985	It is shown in the present study that treatments of the myeloid leukemia HL60 cells with various inducers of cell differentiation (dimethyl sulfoxide, retinoic acid, mezerein, 12-O-tetradecanoylphorbol-13-acetate, teleocidin) caused a dose-dependent reduction of the level of TaDNA transcripts, correlated with the diminution of c-myc transcripts.	Tetradecanoylphorbol Acetate	176-212	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	329-334
30947040-7	2019	Following prolonged exposure, MC-LR significantly upregulated the ratio of proBDNF to BDNF by downregulating the tPA levels, thereby activating downstream signaling pathways to improve the expression of p-JNK, and c-Jun while to inhibit the expression of p-Creb and p-PKC.	Tetradecanoylphorbol Acetate	113-116	brain derived neurotrophic factor	Mus musculus	78-82
31070650-6	2019	Furthermore, TPA obviously assuaged TNF-alpha-evoked up-regulation of IL-8 and IL-6 expression, down-regulation of occludin and ZO-3 expression, and markedly suppressed the activation and protein expression of NF-kappaB p65.	Tetradecanoylphorbol Acetate	13-16	tight junction protein 3	Homo sapiens	128-132
1679947-4	1991	The enhancing effect of lithium on IL-2 production showed some differences from that of tetradecanoylphorbol acetate (TPA) in the following aspects: (i) TPA could reverse the inhibitory effect of anti-CD2 monoclonal antibody on IL-2 production, whereas lithium could not; and (ii) lithium was unable to synergistically induce IL-2 production with anti-CD3 monoclonal antibody as TPA did.	Tetradecanoylphorbol Acetate	153-156	CD2 molecule	Homo sapiens	201-204
30862546-11	2019	Additionally, neutrophil thioredoxin was initially reduced and underwent oxidation after PMA activation.	Tetradecanoylphorbol Acetate	89-92	thioredoxin	Homo sapiens	25-36
2999231-4	1985	Both calcium ionophores, A23187 and ionomycin, in conjunction with 12-O-tetradecanoylphorbol 13-acetate (TPA) mimicked the effect of antigen or interleukin 2 (IL 2) by inducing strong proliferative and alloantigen-specific cytotoxic responses.	Tetradecanoylphorbol Acetate	67-103	interleukin 2	Mus musculus	144-157
2999231-4	1985	Both calcium ionophores, A23187 and ionomycin, in conjunction with 12-O-tetradecanoylphorbol 13-acetate (TPA) mimicked the effect of antigen or interleukin 2 (IL 2) by inducing strong proliferative and alloantigen-specific cytotoxic responses.	Tetradecanoylphorbol Acetate	67-103	interleukin 2	Mus musculus	159-163
2999231-4	1985	Both calcium ionophores, A23187 and ionomycin, in conjunction with 12-O-tetradecanoylphorbol 13-acetate (TPA) mimicked the effect of antigen or interleukin 2 (IL 2) by inducing strong proliferative and alloantigen-specific cytotoxic responses.	Tetradecanoylphorbol Acetate	105-108	interleukin 2	Mus musculus	144-157
1679947-4	1991	The enhancing effect of lithium on IL-2 production showed some differences from that of tetradecanoylphorbol acetate (TPA) in the following aspects: (i) TPA could reverse the inhibitory effect of anti-CD2 monoclonal antibody on IL-2 production, whereas lithium could not; and (ii) lithium was unable to synergistically induce IL-2 production with anti-CD3 monoclonal antibody as TPA did.	Tetradecanoylphorbol Acetate	153-156	CD2 molecule	Homo sapiens	201-204
2999231-4	1985	Both calcium ionophores, A23187 and ionomycin, in conjunction with 12-O-tetradecanoylphorbol 13-acetate (TPA) mimicked the effect of antigen or interleukin 2 (IL 2) by inducing strong proliferative and alloantigen-specific cytotoxic responses.	Tetradecanoylphorbol Acetate	105-108	interleukin 2	Mus musculus	159-163
2999231-5	1985	In addition, Ca2+ ionophore and TPA induced IL 2 receptor expression and IL 2 secretion.	Tetradecanoylphorbol Acetate	32-35	interleukin 2	Mus musculus	44-48
31010051-3	2019	Upon stimulating IL-32theta-expressing and non-expressing cells with phorbol 12-myristate 13-acetate (PMA), the previous microarray analysis showed that IL-13Ralpha2 and IL-13 mRNA expression were significantly decreased by IL-32theta.	Tetradecanoylphorbol Acetate	69-100	interleukin 32	Homo sapiens	17-22
31010051-3	2019	Upon stimulating IL-32theta-expressing and non-expressing cells with phorbol 12-myristate 13-acetate (PMA), the previous microarray analysis showed that IL-13Ralpha2 and IL-13 mRNA expression were significantly decreased by IL-32theta.	Tetradecanoylphorbol Acetate	102-105	interleukin 32	Homo sapiens	17-22
2999231-5	1985	In addition, Ca2+ ionophore and TPA induced IL 2 receptor expression and IL 2 secretion.	Tetradecanoylphorbol Acetate	32-35	interleukin 2	Mus musculus	73-77
1665304-1	1991	The events leading to neutrophil collagenase activation in vivo were analyzed using phorbol myristate acetate (PMA) stimulated neutrophil supernatant.	Tetradecanoylphorbol Acetate	84-109	matrix metallopeptidase 8	Homo sapiens	22-44
3001707-3	1985	The phorbol ester phorbol 12-myristate 13-acetate (PMA) also prevented FSH-induced cell aggregation and suppressed cAMP formation, LH receptor expression, and progesterone production, with an ID50 of 0.2 nM.	Tetradecanoylphorbol Acetate	18-49	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	131-142
3001707-3	1985	The phorbol ester phorbol 12-myristate 13-acetate (PMA) also prevented FSH-induced cell aggregation and suppressed cAMP formation, LH receptor expression, and progesterone production, with an ID50 of 0.2 nM.	Tetradecanoylphorbol Acetate	51-54	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	131-142
30444039-9	2019	The mutation of four cationic amino acids to Ala in the 56-RRNHAR-61 domain in SphK1 reduced the phorbol 12-myristate 13-acetate- and C1P-induced translocation of SphK1 to the PM, however, the capacity of C1P to bind with and activate SphK1 was not affected by this mutation.	Tetradecanoylphorbol Acetate	97-128	sphingosine kinase 1	Homo sapiens	163-168
30444039-9	2019	The mutation of four cationic amino acids to Ala in the 56-RRNHAR-61 domain in SphK1 reduced the phorbol 12-myristate 13-acetate- and C1P-induced translocation of SphK1 to the PM, however, the capacity of C1P to bind with and activate SphK1 was not affected by this mutation.	Tetradecanoylphorbol Acetate	97-128	sphingosine kinase 1	Homo sapiens	163-168
1665304-1	1991	The events leading to neutrophil collagenase activation in vivo were analyzed using phorbol myristate acetate (PMA) stimulated neutrophil supernatant.	Tetradecanoylphorbol Acetate	111-114	matrix metallopeptidase 8	Homo sapiens	22-44
30698330-9	2019	Methods TF expression in primary cultures of human pericytes is not altered by angiogenic cytokines or growth factors, but is actively downregulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	152-183	coagulation factor III, tissue factor	Homo sapiens	8-10
1832383-8	1991	ED6 and LD6 mAb (in the presence of submitogenic doses of the phorbol 12-myristate 13-acetate) also induced the secretion of interleukin 2 by ED6/LD6+ T cell clones expressing TcR gamma/delta or alpha/beta.	Tetradecanoylphorbol Acetate	62-93	interleukin 2	Mus musculus	125-138
30698330-9	2019	Methods TF expression in primary cultures of human pericytes is not altered by angiogenic cytokines or growth factors, but is actively downregulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	185-188	coagulation factor III, tissue factor	Homo sapiens	8-10
30698330-11	2019	Results Exposure to PMA reduced TF mRNA synthesis and shortened the half-life of TF protein from 11 h to 4.5 h. Addition of PMA rapidly triggered endocytosis of cell surface TF, followed by degradation in lysosomes.	Tetradecanoylphorbol Acetate	20-23	coagulation factor III, tissue factor	Homo sapiens	32-34
30698330-11	2019	Results Exposure to PMA reduced TF mRNA synthesis and shortened the half-life of TF protein from 11 h to 4.5 h. Addition of PMA rapidly triggered endocytosis of cell surface TF, followed by degradation in lysosomes.	Tetradecanoylphorbol Acetate	20-23	coagulation factor III, tissue factor	Homo sapiens	81-83
30698330-11	2019	Results Exposure to PMA reduced TF mRNA synthesis and shortened the half-life of TF protein from 11 h to 4.5 h. Addition of PMA rapidly triggered endocytosis of cell surface TF, followed by degradation in lysosomes.	Tetradecanoylphorbol Acetate	20-23	coagulation factor III, tissue factor	Homo sapiens	81-83
30698330-11	2019	Results Exposure to PMA reduced TF mRNA synthesis and shortened the half-life of TF protein from 11 h to 4.5 h. Addition of PMA rapidly triggered endocytosis of cell surface TF, followed by degradation in lysosomes.	Tetradecanoylphorbol Acetate	124-127	coagulation factor III, tissue factor	Homo sapiens	81-83
30698330-11	2019	Results Exposure to PMA reduced TF mRNA synthesis and shortened the half-life of TF protein from 11 h to 4.5 h. Addition of PMA rapidly triggered endocytosis of cell surface TF, followed by degradation in lysosomes.	Tetradecanoylphorbol Acetate	124-127	coagulation factor III, tissue factor	Homo sapiens	81-83
3161611-9	1985	Also present was a prominent PL-Ca-dependent pp19 which remained unchanged following treatment with DMSO, RA, and 1,25(OH)2D3, but which diminished markedly in TPA-treated cells.	Tetradecanoylphorbol Acetate	160-163	stathmin 1	Homo sapiens	45-49
3864525-0	1985	Comparison of the inhibitory effects of retinoids on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activities in CD-1 and Sencar mice.	Tetradecanoylphorbol Acetate	53-89	CD1 antigen complex	Mus musculus	146-150
1832383-8	1991	ED6 and LD6 mAb (in the presence of submitogenic doses of the phorbol 12-myristate 13-acetate) also induced the secretion of interleukin 2 by ED6/LD6+ T cell clones expressing TcR gamma/delta or alpha/beta.	Tetradecanoylphorbol Acetate	62-93	T cell receptor alpha variable 6-3	Mus musculus	176-179
1658015-1	1991	Addition of tumor promoting phorbol esters, such as phorbol 12-myristate 13-acetate (PMA), to many cell lines results in a decrease of 125I-epidermal growth factor (EGF) binding and increased serine/threonine phosphorylation of the EGF receptor in a process termed transmodulation.	Tetradecanoylphorbol Acetate	52-83	epidermal growth factor	Rattus norvegicus	135-163
3876490-3	1985	The K-562 cell line was treated with the superinduction protocol involving phorbol myristate acetate (PMA) for production of human interleukin 1 (IL-1).	Tetradecanoylphorbol Acetate	75-100	interleukin 1 alpha	Homo sapiens	131-150
3876490-3	1985	The K-562 cell line was treated with the superinduction protocol involving phorbol myristate acetate (PMA) for production of human interleukin 1 (IL-1).	Tetradecanoylphorbol Acetate	102-105	interleukin 1 alpha	Homo sapiens	131-150
30838000-8	2019	Upon in vitro activation with PMA plus ionomycin or IL12 plus IL18, fewer MAIT cells isolated from the young adult group expressed IFN-gamma, IL17A and Granzyme B then cells from other age groups while the proportion of cells that expressed TNF-alpha was similar.	Tetradecanoylphorbol Acetate	30-33	granzyme B	Homo sapiens	152-162
1658015-1	1991	Addition of tumor promoting phorbol esters, such as phorbol 12-myristate 13-acetate (PMA), to many cell lines results in a decrease of 125I-epidermal growth factor (EGF) binding and increased serine/threonine phosphorylation of the EGF receptor in a process termed transmodulation.	Tetradecanoylphorbol Acetate	52-83	epidermal growth factor	Rattus norvegicus	165-168
30566262-8	2019	Up-regulation of cytokines (TSLP, IL-4, IL-5, IL-13, RANTES) in human mast cells treated with phorbol 12-myristate 13-acetate and calcium ionophore was also suppressed by boehmite.	Tetradecanoylphorbol Acetate	94-125	thymic stromal lymphopoietin	Homo sapiens	28-32
1658015-1	1991	Addition of tumor promoting phorbol esters, such as phorbol 12-myristate 13-acetate (PMA), to many cell lines results in a decrease of 125I-epidermal growth factor (EGF) binding and increased serine/threonine phosphorylation of the EGF receptor in a process termed transmodulation.	Tetradecanoylphorbol Acetate	52-83	epidermal growth factor	Rattus norvegicus	232-235
2985706-2	1985	The stimulatory effect of rIFN-gamma on HLA-DR antigen expression was suppressed by the addition of the phorbol ester TPA or its analog PDBu to the culture medium.	Tetradecanoylphorbol Acetate	118-121	interferon gamma	Rattus norvegicus	26-36
1658015-1	1991	Addition of tumor promoting phorbol esters, such as phorbol 12-myristate 13-acetate (PMA), to many cell lines results in a decrease of 125I-epidermal growth factor (EGF) binding and increased serine/threonine phosphorylation of the EGF receptor in a process termed transmodulation.	Tetradecanoylphorbol Acetate	85-88	epidermal growth factor	Rattus norvegicus	135-163
1658015-1	1991	Addition of tumor promoting phorbol esters, such as phorbol 12-myristate 13-acetate (PMA), to many cell lines results in a decrease of 125I-epidermal growth factor (EGF) binding and increased serine/threonine phosphorylation of the EGF receptor in a process termed transmodulation.	Tetradecanoylphorbol Acetate	85-88	epidermal growth factor	Rattus norvegicus	165-168
3155737-6	1985	The tumor-promoting phorbol ester, phorbol 12-myristate 13-acetate stimulated the protein kinase C-catalyzed phosphorylation of HMG-CoA reductase.	Tetradecanoylphorbol Acetate	35-66	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	128-145
30346064-5	2019	Levels of c-Fos, c-Jun, and Cox-2 were also significantly reduced by the combination compared to the TPA treated group.	Tetradecanoylphorbol Acetate	101-104	FBJ osteosarcoma oncogene	Mus musculus	10-15
1658015-1	1991	Addition of tumor promoting phorbol esters, such as phorbol 12-myristate 13-acetate (PMA), to many cell lines results in a decrease of 125I-epidermal growth factor (EGF) binding and increased serine/threonine phosphorylation of the EGF receptor in a process termed transmodulation.	Tetradecanoylphorbol Acetate	85-88	epidermal growth factor	Rattus norvegicus	232-235
3155737-7	1985	Increased phosphorylation of HMG-CoA reductase by phorbol 12-myristate 13-acetate suggests a possible in vivo protein kinase C-mediated mechanism for the short-term regulation of HMG-CoA reductase activity.	Tetradecanoylphorbol Acetate	50-81	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	29-46
3155737-7	1985	Increased phosphorylation of HMG-CoA reductase by phorbol 12-myristate 13-acetate suggests a possible in vivo protein kinase C-mediated mechanism for the short-term regulation of HMG-CoA reductase activity.	Tetradecanoylphorbol Acetate	50-81	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	179-196
1658015-4	1991	In Rat-1 fibroblasts treated at 37 degrees C, PMA induced a rapid decrease in EGF binding which persisted for 3 hours.	Tetradecanoylphorbol Acetate	46-49	epidermal growth factor	Rattus norvegicus	78-81
1918168-5	1991	Treatment of the leukemic T cell lines, P30/OKUBO and Jurkat, by the phorbol esters tetradecanoylphorbol acetate (TPA) or phorbol dibutyrate (PDB) results in the down-regulation of the type I, and the up-regulation of the type II, lck transcript levels.	Tetradecanoylphorbol Acetate	84-112	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	231-234
32088709-9	2019	RESULTS: We obtained estimates of 0.221, 0.109, 0.226, and 0 for TPA MET, WK MET, MVPA MET, and SB, respectively.	Tetradecanoylphorbol Acetate	65-68	SAFB like transcription modulator	Homo sapiens	69-72
32088709-10	2019	We found evidence for gene-sex interactions, with males having higher sex-specific heritabilities than females for TPA MET and MVPA MET.	Tetradecanoylphorbol Acetate	115-118	SAFB like transcription modulator	Homo sapiens	119-122
1918168-5	1991	Treatment of the leukemic T cell lines, P30/OKUBO and Jurkat, by the phorbol esters tetradecanoylphorbol acetate (TPA) or phorbol dibutyrate (PDB) results in the down-regulation of the type I, and the up-regulation of the type II, lck transcript levels.	Tetradecanoylphorbol Acetate	114-117	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	231-234
3973461-4	1985	Antithrombin (AT) binding by heparinized PMA materials (compared with PMA control beads) ranged from no AT binding for the material heparinized with carbodiimide (PMA-Alb-Hep(EDC] to 3.6 micrograms/ml packed beads for the material heparinized by radical polymerization (PMA-MA-Hep).	Tetradecanoylphorbol Acetate	41-44	serpin family C member 1	Homo sapiens	0-12
1918168-7	1991	The modulation of lck transcript levels in TPA-treated Jurkat cells is not due to differential RNA stability, suggesting that the two lck promoters are utilized differentially during T cell differentiation.	Tetradecanoylphorbol Acetate	43-46	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	18-21
1918168-7	1991	The modulation of lck transcript levels in TPA-treated Jurkat cells is not due to differential RNA stability, suggesting that the two lck promoters are utilized differentially during T cell differentiation.	Tetradecanoylphorbol Acetate	43-46	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	134-137
30084084-9	2018	Intraperitoneal administration of P2X3 receptor agonist alphabeta-meATP or PKC activator phorbol 12-myristate 13-acetate (PMA) blocked 2-Hz EA analgesia.	Tetradecanoylphorbol Acetate	122-125	purinergic receptor P2X 3	Rattus norvegicus	34-38
1861152-1	1991	We examined the short-term regulation of the phosphorylation of the mid-sized neurofilament subunit (NF-M) by kinases which were activated in rat pheochromocytoma (PC12) cells by nerve growth factor (NGF) and/or 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	212-248	neurofilament medium chain	Rattus norvegicus	101-105
30084084-10	2018	Furthermore, PMA administration increased DRG plasma membrane P2X3 receptor level in PDN rats subject to 2-Hz EA treatment.	Tetradecanoylphorbol Acetate	13-16	purinergic receptor P2X 3	Rattus norvegicus	62-66
6436381-0	1984	The induction of Leu-1 antigen expression in human malignant and normal B cells by phorbol myristic acetate (PMA).	Tetradecanoylphorbol Acetate	109-112	deleted in lymphocytic leukemia 1	Homo sapiens	17-22
6436381-6	1984	PMA also induced the appearance of Leu-1 antigen-positive B cells in cultures of normal peripheral blood mononuclear cells.	Tetradecanoylphorbol Acetate	0-3	deleted in lymphocytic leukemia 1	Homo sapiens	35-40
1861152-1	1991	We examined the short-term regulation of the phosphorylation of the mid-sized neurofilament subunit (NF-M) by kinases which were activated in rat pheochromocytoma (PC12) cells by nerve growth factor (NGF) and/or 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	250-253	neurofilament medium chain	Rattus norvegicus	101-105
1861152-2	1991	We found that NGF and TPA, alone or in combination, increased (a) the incorporation of [32P]Pi into NF-M and (b) the rate of conversion of NF-M from a poorly phosphorylated to a more highly phosphorylated form.	Tetradecanoylphorbol Acetate	22-25	neurofilament medium chain	Rattus norvegicus	100-104
1861152-2	1991	We found that NGF and TPA, alone or in combination, increased (a) the incorporation of [32P]Pi into NF-M and (b) the rate of conversion of NF-M from a poorly phosphorylated to a more highly phosphorylated form.	Tetradecanoylphorbol Acetate	22-25	neurofilament medium chain	Rattus norvegicus	139-143
6207184-2	1984	At 0.1 microgram/ml, TPA depressed the specific activities of lactate dehydrogenase and gamma-glutamyl transpeptidase, whereas 2 mM PB depressed gamma-glutamyl transpeptidase and alkaline phosphatase.	Tetradecanoylphorbol Acetate	21-24	gamma-glutamyltransferase 1	Rattus norvegicus	88-117
30049418-5	2018	In a TPA-induced mouse ear edema model, PEP-1-PEA15 significantly reduced ear weight and thickness as well as MAPK activation as well as the expression levels of COX-2, iNOS, IL-6, IL-1beta, and TNF-alpha.	Tetradecanoylphorbol Acetate	5-8	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	40-45
1860872-5	1991	In detached permeabilized cells, PMA pretreatment caused a rapid phosphorylation of immunoprecipitated 5-HT1A receptors, with an approximately 3-4-fold increase that was maximal after 15 min and persisted for 90 min.	Tetradecanoylphorbol Acetate	33-36	5-hydroxytryptamine receptor 1A	Homo sapiens	103-109
30049418-5	2018	In a TPA-induced mouse ear edema model, PEP-1-PEA15 significantly reduced ear weight and thickness as well as MAPK activation as well as the expression levels of COX-2, iNOS, IL-6, IL-1beta, and TNF-alpha.	Tetradecanoylphorbol Acetate	5-8	proliferation and apoptosis adaptor protein 15A	Mus musculus	46-51
6090008-2	1984	Among the tested substances, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 12-hexadecanoyl-phorbol-13-acetate (HPA) and teleocidin induced HTLV structural protein p19 and p24.	Tetradecanoylphorbol Acetate	29-66	interleukin 23 subunit alpha	Homo sapiens	162-165
6090008-2	1984	Among the tested substances, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 12-hexadecanoyl-phorbol-13-acetate (HPA) and teleocidin induced HTLV structural protein p19 and p24.	Tetradecanoylphorbol Acetate	68-71	interleukin 23 subunit alpha	Homo sapiens	162-165
30098331-7	2018	When combined with 17-AAG, PMA had additive effect on ErbB2 internalization indicating that Hsp90 inhibition and PKC activation induce internalization by alternative mechanisms.	Tetradecanoylphorbol Acetate	27-30	heat shock protein 90 alpha family class A member 1	Homo sapiens	92-97
1911548-1	1991	Activation of T cells by antigen, lectin, or a combination of phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) leads to the induction of genes for a set of lymphokines, including granulocyte-macrophage colony-stimulating factor (GM-CSF).	Tetradecanoylphorbol Acetate	92-95	colony stimulating factor 2	Homo sapiens	196-244
6332169-8	1984	Poly perforin 1 assembled by CTLL-2 upon stimulation with concanavalin A (Con A) and phorbol myristate acetate (PMA) was isolated by detergent extraction and gel filtration.	Tetradecanoylphorbol Acetate	85-110	perforin 1	Homo sapiens	5-15
1911548-1	1991	Activation of T cells by antigen, lectin, or a combination of phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) leads to the induction of genes for a set of lymphokines, including granulocyte-macrophage colony-stimulating factor (GM-CSF).	Tetradecanoylphorbol Acetate	92-95	colony stimulating factor 2	Homo sapiens	246-252
6332169-8	1984	Poly perforin 1 assembled by CTLL-2 upon stimulation with concanavalin A (Con A) and phorbol myristate acetate (PMA) was isolated by detergent extraction and gel filtration.	Tetradecanoylphorbol Acetate	112-115	perforin 1	Homo sapiens	5-15
30542585-5	2018	Moreover, the CAS-C1-parallel G4 system exhibits large two-photon absorption (TPA) cross-sections and molecular brightness in the second NIR biological transparency window (lambda   1275 nm), making it an ideal candidate for NIR-to-NIR ultrasensitive two-photon procedures.	Tetradecanoylphorbol Acetate	78-81	dynein axonemal intermediate chain 7	Homo sapiens	14-20
1864967-4	1991	In contrast, treatment of these cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) was associated with increases (within 1 h) in EGR-1 mRNA levels.	Tetradecanoylphorbol Acetate	43-79	early growth response 1	Homo sapiens	132-137
30015874-0	2018	P2X7 receptor regulates EMMPRIN and MMP-9 expression through AMPK/MAPK signaling in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	84-87	basigin (Ok blood group)	Homo sapiens	24-31
30015874-4	2018	P2X7R may serve a crucial role in the development of atherosclerosis; therefore, the present study aimed to determine whether P2X7R regulated the expression of EMMPRIN and MMP-9 in phorbol 12-myristate 13-acetate (PMA)-induced macrophages.	Tetradecanoylphorbol Acetate	181-212	basigin (Ok blood group)	Homo sapiens	160-167
30015874-4	2018	P2X7R may serve a crucial role in the development of atherosclerosis; therefore, the present study aimed to determine whether P2X7R regulated the expression of EMMPRIN and MMP-9 in phorbol 12-myristate 13-acetate (PMA)-induced macrophages.	Tetradecanoylphorbol Acetate	214-217	basigin (Ok blood group)	Homo sapiens	160-167
6208480-4	1984	The receptor was phosphorylated on serine and threonine residues in normally growing and quiescent cells, and treatment with EGF or the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a two- to threefold increase in receptor-bound phosphate.	Tetradecanoylphorbol Acetate	151-187	epidermal growth factor	Homo sapiens	125-128
6208480-7	1984	Prior treatment with TPA inhibited the EGF-dependent appearance of phosphotyrosine in the receptor.	Tetradecanoylphorbol Acetate	21-24	epidermal growth factor	Homo sapiens	39-42
6610701-8	1984	The IL 2 defect could be significantly repaired by the addition of PMA to the cultures.	Tetradecanoylphorbol Acetate	67-70	interleukin 2	Mus musculus	4-8
1864967-4	1991	In contrast, treatment of these cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) was associated with increases (within 1 h) in EGR-1 mRNA levels.	Tetradecanoylphorbol Acetate	81-84	early growth response 1	Homo sapiens	132-137
29627456-3	2018	Comparative flow cytometric analyses of lymphocyte subsets stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin revealed differences in expression of IL-17A by CD4, CD8, and gammadelta T cells across ruminants and swine species.	Tetradecanoylphorbol Acetate	75-106	interleukin-17A	Sus scrofa	165-171
1864967-5	1991	The induction of monocytic differentiation by TPA and other agents was further associated with increases in EGR-2, but not EGR-3 or EGR-4, mRNA levels in these cells.	Tetradecanoylphorbol Acetate	46-49	early growth response 2	Homo sapiens	108-113
29627456-3	2018	Comparative flow cytometric analyses of lymphocyte subsets stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin revealed differences in expression of IL-17A by CD4, CD8, and gammadelta T cells across ruminants and swine species.	Tetradecanoylphorbol Acetate	108-111	interleukin-17A	Sus scrofa	165-171
1864967-5	1991	The induction of monocytic differentiation by TPA and other agents was further associated with increases in EGR-2, but not EGR-3 or EGR-4, mRNA levels in these cells.	Tetradecanoylphorbol Acetate	46-49	early growth response 3	Homo sapiens	123-128
1667989-6	1991	Both PMA and zymosan also significantly enhanced PMN CL in both RA (41.51 +/- 17.42, 40.0 +/- 26.51) and HS (43.42 +/- 17.28, 39.91 +/- 27.24), and those values were much higher than those of controls or via PAF stimulation, but, again, there was no difference between RA and HS groups.	Tetradecanoylphorbol Acetate	5-8	PCNA clamp associated factor	Homo sapiens	208-211
29844066-5	2018	Furthermore, Sos1 disruption delayed the onset of tumor initiation, decreased tumor growth, and prevented malignant progression of papillomas in a DMBA (7,12-dimethylbenz[alpha]anthracene)/TPA (12-O-tetradecanoylphorbol-13-acetate)-induced skin carcinogenesis model.	Tetradecanoylphorbol Acetate	189-192	SOS Ras/Rac guanine nucleotide exchange factor 1	Mus musculus	13-17
29844066-5	2018	Furthermore, Sos1 disruption delayed the onset of tumor initiation, decreased tumor growth, and prevented malignant progression of papillomas in a DMBA (7,12-dimethylbenz[alpha]anthracene)/TPA (12-O-tetradecanoylphorbol-13-acetate)-induced skin carcinogenesis model.	Tetradecanoylphorbol Acetate	194-230	SOS Ras/Rac guanine nucleotide exchange factor 1	Mus musculus	13-17
6232000-5	1984	In the presence of PHA and phorbol myristate acetate, FL cells produced a growth factor, tentatively identified as Interleukin 2 (IL-2) by its ability to promote the proliferation of an IL-2-dependent murine T-cell line.	Tetradecanoylphorbol Acetate	27-52	interleukin 2	Mus musculus	115-128
6232000-5	1984	In the presence of PHA and phorbol myristate acetate, FL cells produced a growth factor, tentatively identified as Interleukin 2 (IL-2) by its ability to promote the proliferation of an IL-2-dependent murine T-cell line.	Tetradecanoylphorbol Acetate	27-52	interleukin 2	Mus musculus	130-134
6232000-5	1984	In the presence of PHA and phorbol myristate acetate, FL cells produced a growth factor, tentatively identified as Interleukin 2 (IL-2) by its ability to promote the proliferation of an IL-2-dependent murine T-cell line.	Tetradecanoylphorbol Acetate	27-52	interleukin 2	Mus musculus	186-190
1677566-0	1991	Transactivation of the TPA-responsive element by the oncogenic C-erbB-2 protein is partly mediated by protein kinase C. The mutant c-erbB-2 gene encoding a protein with Glu instead of Val-659 in the transmembrane domain is able to transform NIH3T3 cells, while the wild type c-erbB-2 unless overexpressed does not.	Tetradecanoylphorbol Acetate	23-26	erb-b2 receptor tyrosine kinase 2	Mus musculus	63-71
6321474-3	1984	Phosphoamino acid analysis of radiolabeled EGF receptors isolated from these cells revealed several differences: the relative abundance of phosphotyrosine in EGF receptors was increased in cells treated with EGF, but decreased in cells treated with TPA; the overall relative abundance of phosphothreonine in EGF receptors was decreased in cells treated with EGF, but remained constant within the limits of experimental detection in cells treated with TPA.	Tetradecanoylphorbol Acetate	249-252	epidermal growth factor	Homo sapiens	158-161
6321474-3	1984	Phosphoamino acid analysis of radiolabeled EGF receptors isolated from these cells revealed several differences: the relative abundance of phosphotyrosine in EGF receptors was increased in cells treated with EGF, but decreased in cells treated with TPA; the overall relative abundance of phosphothreonine in EGF receptors was decreased in cells treated with EGF, but remained constant within the limits of experimental detection in cells treated with TPA.	Tetradecanoylphorbol Acetate	249-252	epidermal growth factor	Homo sapiens	158-161
6321474-3	1984	Phosphoamino acid analysis of radiolabeled EGF receptors isolated from these cells revealed several differences: the relative abundance of phosphotyrosine in EGF receptors was increased in cells treated with EGF, but decreased in cells treated with TPA; the overall relative abundance of phosphothreonine in EGF receptors was decreased in cells treated with EGF, but remained constant within the limits of experimental detection in cells treated with TPA.	Tetradecanoylphorbol Acetate	249-252	epidermal growth factor	Homo sapiens	158-161
6321474-3	1984	Phosphoamino acid analysis of radiolabeled EGF receptors isolated from these cells revealed several differences: the relative abundance of phosphotyrosine in EGF receptors was increased in cells treated with EGF, but decreased in cells treated with TPA; the overall relative abundance of phosphothreonine in EGF receptors was decreased in cells treated with EGF, but remained constant within the limits of experimental detection in cells treated with TPA.	Tetradecanoylphorbol Acetate	249-252	epidermal growth factor	Homo sapiens	158-161
6321474-3	1984	Phosphoamino acid analysis of radiolabeled EGF receptors isolated from these cells revealed several differences: the relative abundance of phosphotyrosine in EGF receptors was increased in cells treated with EGF, but decreased in cells treated with TPA; the overall relative abundance of phosphothreonine in EGF receptors was decreased in cells treated with EGF, but remained constant within the limits of experimental detection in cells treated with TPA.	Tetradecanoylphorbol Acetate	451-454	epidermal growth factor	Homo sapiens	158-161
29673913-6	2018	Monomeric or aggregated alpha-syn was immobilized at the centre of glass coverslips and treated with either cell free medium, undifferentiated THP-1 cells or microglial-like phorbol-12-myristate-13-acetate differentiated THP-1 cells (48 h; n = 3).	Tetradecanoylphorbol Acetate	174-205	synuclein alpha	Homo sapiens	24-33
29555853-4	2018	Wild-type p65 or p65DeltaSE both rescue NF-kappaB-dependent gene expression in p65-deficient murine hippocampal neurons responding to diffuse (PMA/ionomycin) stimulation.	Tetradecanoylphorbol Acetate	143-146	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	10-13
29555853-4	2018	Wild-type p65 or p65DeltaSE both rescue NF-kappaB-dependent gene expression in p65-deficient murine hippocampal neurons responding to diffuse (PMA/ionomycin) stimulation.	Tetradecanoylphorbol Acetate	143-146	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	17-20
29555853-4	2018	Wild-type p65 or p65DeltaSE both rescue NF-kappaB-dependent gene expression in p65-deficient murine hippocampal neurons responding to diffuse (PMA/ionomycin) stimulation.	Tetradecanoylphorbol Acetate	143-146	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	17-20
29632235-5	2018	Chromatin immunoprecipitation studies and electrophoretic mobility shift assay using phorbol 12-myristate 13-acetate (PMA)-treated human erythroleukemia cells revealed RUNX1 binding to RAB1B promoter region RUNX1 consensus sites, and their mutation reduced the promoter activity.	Tetradecanoylphorbol Acetate	85-116	RUNX family transcription factor 1	Homo sapiens	168-173
29632235-5	2018	Chromatin immunoprecipitation studies and electrophoretic mobility shift assay using phorbol 12-myristate 13-acetate (PMA)-treated human erythroleukemia cells revealed RUNX1 binding to RAB1B promoter region RUNX1 consensus sites, and their mutation reduced the promoter activity.	Tetradecanoylphorbol Acetate	85-116	RUNX family transcription factor 1	Homo sapiens	207-212
6321474-3	1984	Phosphoamino acid analysis of radiolabeled EGF receptors isolated from these cells revealed several differences: the relative abundance of phosphotyrosine in EGF receptors was increased in cells treated with EGF, but decreased in cells treated with TPA; the overall relative abundance of phosphothreonine in EGF receptors was decreased in cells treated with EGF, but remained constant within the limits of experimental detection in cells treated with TPA.	Tetradecanoylphorbol Acetate	451-454	epidermal growth factor	Homo sapiens	158-161
6321474-3	1984	Phosphoamino acid analysis of radiolabeled EGF receptors isolated from these cells revealed several differences: the relative abundance of phosphotyrosine in EGF receptors was increased in cells treated with EGF, but decreased in cells treated with TPA; the overall relative abundance of phosphothreonine in EGF receptors was decreased in cells treated with EGF, but remained constant within the limits of experimental detection in cells treated with TPA.	Tetradecanoylphorbol Acetate	451-454	epidermal growth factor	Homo sapiens	158-161
6321474-3	1984	Phosphoamino acid analysis of radiolabeled EGF receptors isolated from these cells revealed several differences: the relative abundance of phosphotyrosine in EGF receptors was increased in cells treated with EGF, but decreased in cells treated with TPA; the overall relative abundance of phosphothreonine in EGF receptors was decreased in cells treated with EGF, but remained constant within the limits of experimental detection in cells treated with TPA.	Tetradecanoylphorbol Acetate	451-454	epidermal growth factor	Homo sapiens	158-161
29632235-5	2018	Chromatin immunoprecipitation studies and electrophoretic mobility shift assay using phorbol 12-myristate 13-acetate (PMA)-treated human erythroleukemia cells revealed RUNX1 binding to RAB1B promoter region RUNX1 consensus sites, and their mutation reduced the promoter activity.	Tetradecanoylphorbol Acetate	118-121	RUNX family transcription factor 1	Homo sapiens	168-173
1677566-0	1991	Transactivation of the TPA-responsive element by the oncogenic C-erbB-2 protein is partly mediated by protein kinase C. The mutant c-erbB-2 gene encoding a protein with Glu instead of Val-659 in the transmembrane domain is able to transform NIH3T3 cells, while the wild type c-erbB-2 unless overexpressed does not.	Tetradecanoylphorbol Acetate	23-26	erb-b2 receptor tyrosine kinase 2	Mus musculus	131-139
1677566-0	1991	Transactivation of the TPA-responsive element by the oncogenic C-erbB-2 protein is partly mediated by protein kinase C. The mutant c-erbB-2 gene encoding a protein with Glu instead of Val-659 in the transmembrane domain is able to transform NIH3T3 cells, while the wild type c-erbB-2 unless overexpressed does not.	Tetradecanoylphorbol Acetate	23-26	erb-b2 receptor tyrosine kinase 2	Mus musculus	275-283
1677566-2	1991	Transient expression of this active c-erbB-2 stimulated the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, serum response element, and cyclic AMP response element.	Tetradecanoylphorbol Acetate	60-96	erb-b2 receptor tyrosine kinase 2	Mus musculus	36-44
29710490-6	2018	Furthermore, a proton beam suppressed TPA-induced gene expressions of urokinase plasminogen activator (uPA), uPA receptor (uPAR), Snail-1 and vascular endothelial growth factor (VEGF) in HepG2 cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	38-41	plasminogen activator, urokinase receptor	Homo sapiens	109-121
6321474-4	1984	Two-dimensional mapping of the radiolabeled phosphopeptides produced from EGF receptors isolated by immunoprecipitation and treated with trypsin revealed 9 independent labeled regions, 2 of which contained phosphothreonine and were present only in EGF- or TPA-treated cells.	Tetradecanoylphorbol Acetate	256-259	epidermal growth factor	Homo sapiens	74-77
6321474-5	1984	These two phosphopeptide regions were more highly labeled in cells treated with TPA than with EGF.	Tetradecanoylphorbol Acetate	80-83	epidermal growth factor	Homo sapiens	94-97
29710490-6	2018	Furthermore, a proton beam suppressed TPA-induced gene expressions of urokinase plasminogen activator (uPA), uPA receptor (uPAR), Snail-1 and vascular endothelial growth factor (VEGF) in HepG2 cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	38-41	plasminogen activator, urokinase receptor	Homo sapiens	123-127
1677566-2	1991	Transient expression of this active c-erbB-2 stimulated the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, serum response element, and cyclic AMP response element.	Tetradecanoylphorbol Acetate	98-101	erb-b2 receptor tyrosine kinase 2	Mus musculus	36-44
1902623-4	1991	In 72 percent of patients, the undetectable TPA activity was correlated with abnormally high PAI activity; PAI levels were normal in all members of the control group, their mean value being 0.74 versus 8.63 IU/ml for SLE patients (P less than .01).	Tetradecanoylphorbol Acetate	44-47	serpin family E member 1	Homo sapiens	93-96
28065940-7	2018	In vitro experiments also supported the conclusion that CD24 deficiency impaired IFN-gamma production by CD4+ T cells following ConA, CD3/CD28 and phorbol myristate acetate/ionomycin stimulation.	Tetradecanoylphorbol Acetate	147-172	CD24a antigen	Mus musculus	56-60
6198073-0	1984	Early decline in c-myb oncogene expression in the differentiation of human myeloblastic leukemia (ML-1) cells induced with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	123-159	MYB proto-oncogene, transcription factor	Homo sapiens	17-22
6198073-4	1984	The level of c-myb RNA was decreased by greater than 50% as early as 3 hr after 12-O-tetradecanoylphorbol-13-acetate exposure, and at 8 to 72 hr the reduction was greater than or equal to 4-fold.	Tetradecanoylphorbol Acetate	80-116	MYB proto-oncogene, transcription factor	Homo sapiens	13-18
1902623-9	1991	It is concluded that most patients with SLE display severe abnormalities in the TPA/PAI anti-thrombotic system and that these abnormalities may be related to the lupus thrombophilia, apparently multifactorial in its origin.	Tetradecanoylphorbol Acetate	80-83	serpin family E member 1	Homo sapiens	84-87
2015852-1	1991	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates a rapid increase in ornithine decarboxylase (EC 4.1.1.17; ODC) activity in target cells.	Tetradecanoylphorbol Acetate	19-55	ornithine decarboxylase 1	Rattus norvegicus	93-116
6697440-0	1984	Relation between induction of rat hepatic ornithine decarboxylase activity by tumor promoters 12-O-tetradecanoylphorbol-13-acetate and phenobarbital and levels of the polyamines putrescine, spermidine and spermine, in vivo; differential effects of retinyl-acetate.	Tetradecanoylphorbol Acetate	94-130	ornithine decarboxylase 1	Rattus norvegicus	42-65
6228583-4	1984	The surviving spleen cells were then cultured for another 5 days under the same conditions plus 10% interleukin 2-rich supernatant from a clone of EL-4 thymoma cells stimulated with phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	182-213	interleukin 2	Mus musculus	100-113
29535732-7	2018	More importantly, MEK1/2 inhibitors significantly increased the TLR9-mediated IFN-I production blocked in both GEN2.2 cells and primary pDCs upon stimulation of BCR-like or phorbol 12-myristate 13-acetate-induced protein kinase C (PKC) signaling.	Tetradecanoylphorbol Acetate	173-204	mitogen-activated protein kinase kinase 1	Homo sapiens	18-24
29207123-0	2018	NACHT, LRR and PYD domains-containing protein 3 inflammasome is activated and inhibited by berberine via toll-like receptor 4/myeloid differentiation primary response gene 88/nuclear factor-kappaB pathway, in phorbol 12-myristate 13-acetate-induced macrophages.	Tetradecanoylphorbol Acetate	209-240	toll like receptor 4	Homo sapiens	105-125
29385060-0	2018	Synthesis of a Cleaved Form of Osteopontin by THP-1 Cells and Its Alteration by Phorbol 12-Myristate 13-Acetate and BCG Infection.	Tetradecanoylphorbol Acetate	80-111	secreted phosphoprotein 1	Homo sapiens	31-42
29385060-2	2018	Various forms of OPN were identified in human monocytic THP-1 cells stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	82-113	secreted phosphoprotein 1	Homo sapiens	17-20
29385060-2	2018	Various forms of OPN were identified in human monocytic THP-1 cells stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	115-118	secreted phosphoprotein 1	Homo sapiens	17-20
2015852-1	1991	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates a rapid increase in ornithine decarboxylase (EC 4.1.1.17; ODC) activity in target cells.	Tetradecanoylphorbol Acetate	19-55	ornithine decarboxylase 1	Rattus norvegicus	131-134
29385060-6	2018	Small amounts of full-length (FL) and thrombin-cleaved (Tr) OPN were detected by ELISA in the supernatants of non-PMA-stimulated cells, and increased levels of all forms, including undefined (Ud) OPN, in PMA-stimulated cells.	Tetradecanoylphorbol Acetate	114-117	secreted phosphoprotein 1	Homo sapiens	60-63
2015852-1	1991	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates a rapid increase in ornithine decarboxylase (EC 4.1.1.17; ODC) activity in target cells.	Tetradecanoylphorbol Acetate	57-60	ornithine decarboxylase 1	Rattus norvegicus	93-116
28513986-7	2017	TPA markedly downregulated the expression of PKCalpha, PKCdelta, and PKCepsilon, suggesting that PKCdelta or PKCepsilon activation could contribute to inhibition of glucose transport by FFA.	Tetradecanoylphorbol Acetate	0-3	protein kinase C epsilon	Homo sapiens	69-79
2015852-1	1991	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates a rapid increase in ornithine decarboxylase (EC 4.1.1.17; ODC) activity in target cells.	Tetradecanoylphorbol Acetate	57-60	ornithine decarboxylase 1	Rattus norvegicus	131-134
28513986-7	2017	TPA markedly downregulated the expression of PKCalpha, PKCdelta, and PKCepsilon, suggesting that PKCdelta or PKCepsilon activation could contribute to inhibition of glucose transport by FFA.	Tetradecanoylphorbol Acetate	0-3	protein kinase C epsilon	Homo sapiens	109-119
2015852-2	1991	Here we demonstrate that this process involves a rapid accumulation of ODC mRNA, which is maximal 3 h after treatment (three- to eightfold greater than control cells) and decays to control levels within 18 h. Stimulation of ODC mRNA by TPA is blocked by phorbol dibutyrate down-regulation of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	236-239	ornithine decarboxylase 1	Rattus norvegicus	71-74
28513986-9	2017	TPA also activated Protein Kinase D 1(PKD1) in FFA-exposed cardiomyocytes, as assessed by autophosphorylation of PKD1 on Y916.	Tetradecanoylphorbol Acetate	0-3	polycystin 1, transient receptor potential channel interacting	Homo sapiens	38-42
28513986-9	2017	TPA also activated Protein Kinase D 1(PKD1) in FFA-exposed cardiomyocytes, as assessed by autophosphorylation of PKD1 on Y916.	Tetradecanoylphorbol Acetate	0-3	polycystin 1, transient receptor potential channel interacting	Homo sapiens	113-117
2015852-2	1991	Here we demonstrate that this process involves a rapid accumulation of ODC mRNA, which is maximal 3 h after treatment (three- to eightfold greater than control cells) and decays to control levels within 18 h. Stimulation of ODC mRNA by TPA is blocked by phorbol dibutyrate down-regulation of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	236-239	ornithine decarboxylase 1	Rattus norvegicus	224-227
28513986-10	2017	Pharmaceutical inhibition of PKD1 only partially prevented the improvement of glucose transport by TPA.	Tetradecanoylphorbol Acetate	99-102	polycystin 1, transient receptor potential channel interacting	Homo sapiens	29-33
6086044-8	1984	While spleen cells from such mice were, indeed, unable to produce IL 2 or to proliferate when stimulated with concanavalin A (Con A), the combination of Con A plus the comitogen phorbol myristate acetate (PMA) engendered substantial IL 2 production and normal cellular proliferation.	Tetradecanoylphorbol Acetate	178-203	interleukin 2	Mus musculus	233-237
2015852-4	1991	However, the non-PKC-specific protein kinase inhibitor HA1004 also suppressed expression of ODC mRNA in response to TPA, under conditions where it did not inhibit PKC, suggesting that additional kinases may be involved in the intracellular signalling process.	Tetradecanoylphorbol Acetate	116-119	ornithine decarboxylase 1	Rattus norvegicus	92-95
6086044-10	1984	We found that culturing lpr spleen cells with an anti-IL 2 receptor antibody abrogated the mitogenicity of Con A + PMA; that on stimulation with Con A + PMA, MRL-lpr/lpr T cells expressed IL 2 receptors, and that addition of recombinant IL 2 to the receptor positive population resulted in marked proliferation.	Tetradecanoylphorbol Acetate	115-118	interleukin 2	Mus musculus	54-58
6086044-10	1984	We found that culturing lpr spleen cells with an anti-IL 2 receptor antibody abrogated the mitogenicity of Con A + PMA; that on stimulation with Con A + PMA, MRL-lpr/lpr T cells expressed IL 2 receptors, and that addition of recombinant IL 2 to the receptor positive population resulted in marked proliferation.	Tetradecanoylphorbol Acetate	115-118	interleukin 2	Mus musculus	188-192
2022708-8	1991	PMA inhibited oxytocin-provoked IP1 turnover (P less than 0.05).	Tetradecanoylphorbol Acetate	0-3	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	32-35
6086044-10	1984	We found that culturing lpr spleen cells with an anti-IL 2 receptor antibody abrogated the mitogenicity of Con A + PMA; that on stimulation with Con A + PMA, MRL-lpr/lpr T cells expressed IL 2 receptors, and that addition of recombinant IL 2 to the receptor positive population resulted in marked proliferation.	Tetradecanoylphorbol Acetate	115-118	interleukin 2	Mus musculus	188-192
28993516-4	2017	Topical IDR-1002 treatment successfully dampened PMA-induced ear edema, proinflammatory cytokine production, reactive oxygen and nitrogen species release, and neutrophil recruitment in the ears of CD1 mice.	Tetradecanoylphorbol Acetate	49-52	CD1 antigen complex	Mus musculus	197-200
29149784-0	2017	Anti-inflammatory Property of beta-D-Mannuronic Acid (M2000) on Expression and Activity of Matrix Metalloproteinase-2 and -9 through CD147 Molecule in Phorbol Myristate Acetate-differentiated THP-1 Cells.	Tetradecanoylphorbol Acetate	151-176	basigin (Ok blood group)	Homo sapiens	133-138
6540831-2	1984	Whereas uninduced lines exhibited only a discrete reseau of vimentin, TPA treated cells acquire a very rich vimentin network similar to that of normal monocytes.	Tetradecanoylphorbol Acetate	70-73	vimentin	Homo sapiens	108-116
1850009-1	1991	The promoter for the 2.8-kb RNA of Epstein-Barr virus encoding BZLF1 and BRLF1 was identified and shown to be activated by both BZLF1 and BRLF1 but not by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	155-191	protein Zta	Human gammaherpesvirus 4	63-68
2029727-7	1991	An increase in PENK mRNA levels has been also observed in cultures treated with 8-Br-cAMP, phorbol 12-myristate-13-acetate (TPA), or dexamethasone.	Tetradecanoylphorbol Acetate	91-122	proenkephalin	Rattus norvegicus	15-19
6419742-3	1983	Similarly, the stimulation of 2DG uptake by a tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) was prevented by EGTA, whereas the epidermal growth factor (EGF)-stimulated 2DG uptake was not affected by EGTA alone, but in the presence of both EGTA and A23187 which effectively depleted cellular Ca2+ content, EGF could no longer stimulate 2DG uptake.	Tetradecanoylphorbol Acetate	61-97	epidermal growth factor	Mus musculus	164-167
6419742-3	1983	Similarly, the stimulation of 2DG uptake by a tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) was prevented by EGTA, whereas the epidermal growth factor (EGF)-stimulated 2DG uptake was not affected by EGTA alone, but in the presence of both EGTA and A23187 which effectively depleted cellular Ca2+ content, EGF could no longer stimulate 2DG uptake.	Tetradecanoylphorbol Acetate	99-102	epidermal growth factor	Mus musculus	317-320
6604573-6	1983	TPA induces the production of interleukin-2 (IL-2) in lectin-treated PNA-negative populations but not in PNA-positive cells.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Mus musculus	30-43
6604573-6	1983	TPA induces the production of interleukin-2 (IL-2) in lectin-treated PNA-negative populations but not in PNA-positive cells.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Mus musculus	45-49
27887857-10	2017	In vitro studies demonstrated that the inhibition of DPP-4 promoted PMA-induced monocytic cells differentiation, with increased CD68 and p21 expression, regulated by extracellular signal-regulated protein kinase 1/2 activation.	Tetradecanoylphorbol Acetate	68-71	dipeptidyl peptidase 4	Homo sapiens	53-58
27887857-10	2017	In vitro studies demonstrated that the inhibition of DPP-4 promoted PMA-induced monocytic cells differentiation, with increased CD68 and p21 expression, regulated by extracellular signal-regulated protein kinase 1/2 activation.	Tetradecanoylphorbol Acetate	68-71	H3 histone pseudogene 16	Homo sapiens	137-140
2029727-7	1991	An increase in PENK mRNA levels has been also observed in cultures treated with 8-Br-cAMP, phorbol 12-myristate-13-acetate (TPA), or dexamethasone.	Tetradecanoylphorbol Acetate	124-127	proenkephalin	Rattus norvegicus	15-19
28369741-7	2017	While healthy control neutrophils incubated with GM-CSF became primed to produce ROS in response to stimulation with fMLP and phorbol-12-myristate-12-acetate (PMA), RA neutrophils produced increased levels of ROS without the need for priming.	Tetradecanoylphorbol Acetate	159-162	colony stimulating factor 2	Homo sapiens	49-55
28512205-0	2017	Phorbol-12-myristate-13-acetate-mediated stabilization of leukemia inhibitory factor (lif) mRNA: involvement of Nucleolin and PCBP1.	Tetradecanoylphorbol Acetate	0-31	LIF interleukin 6 family cytokine	Homo sapiens	58-84
2029727-11	1991	The increase in PENK mRNA in depolarized and in TPA-dexamethasone-, or 8-Br-cAMP-treated cultures was not accompanied by a significant increase in the amount of free immunoreactive met-enkephalin.	Tetradecanoylphorbol Acetate	48-51	proenkephalin	Rattus norvegicus	16-20
28512205-0	2017	Phorbol-12-myristate-13-acetate-mediated stabilization of leukemia inhibitory factor (lif) mRNA: involvement of Nucleolin and PCBP1.	Tetradecanoylphorbol Acetate	0-31	LIF interleukin 6 family cytokine	Homo sapiens	86-89
1850359-6	1991	Moreover, phorbol 12-myristate 13-acetate led to an early, marked down-regulation of the 75-kDa TNFR expression, followed by a later modest increase after greater than 24 h. In contrast to other cell systems where htr mAb have been found either to mimic or to inhibit TNF action, htr mAb had insignificant effects in assays for restimulation of preactivated B cells.	Tetradecanoylphorbol Acetate	10-41	TNF receptor superfamily member 1A	Homo sapiens	96-100
28512205-2	2017	The present study reveals that enhanced expression of LIF in response to PMA (phorbol-12-myristate-13-acetate) in human histiocytic lymphoma cell line U937 largely happens through stabilization of its mRNA.	Tetradecanoylphorbol Acetate	73-76	LIF interleukin 6 family cytokine	Homo sapiens	54-57
28512205-2	2017	The present study reveals that enhanced expression of LIF in response to PMA (phorbol-12-myristate-13-acetate) in human histiocytic lymphoma cell line U937 largely happens through stabilization of its mRNA.	Tetradecanoylphorbol Acetate	78-109	LIF interleukin 6 family cytokine	Homo sapiens	54-57
28512205-5	2017	Affinity chromatography followed by western blot and RNA co-immunoprecipitation of PMA-treated U937 extract identified Nucleolin and PCBP1 as two protein trans-factors interacting with lif mRNA, specifically to the proximal non-conventional AU-rich region.	Tetradecanoylphorbol Acetate	83-86	LIF interleukin 6 family cytokine	Homo sapiens	185-188
6226737-2	1983	Supernatant from phorbol myristate acetate-induced EL-4 cells was used as a source of IL 2 in these assays, which therefore were independent of the presence of the Lyt-2-, IL 2-producing cells known to be deficient in aging mice.	Tetradecanoylphorbol Acetate	17-42	interleukin 2	Mus musculus	86-90
1645358-4	1991	Phorbol myristate acetate (PMA) induced rapid loss of surface TM activity (approximately 8 h) and later increased TM mRNA levels between 4 h and 40 h (maximum at 24 h), resulting in biphasic effects on TM activity.	Tetradecanoylphorbol Acetate	0-25	thrombomodulin	Homo sapiens	62-64
6323154-5	1983	Among a variety of phorbol esters tested, tetradecanoyl phorbol acetate, a potent tumor promotor, was shown to be the most effective compound in inhibiting 125I-labeled EGF binding to its receptors.	Tetradecanoylphorbol Acetate	42-71	epidermal growth factor	Homo sapiens	169-172
6604035-4	1983	Upon induction of proliferation of these cells by short-term culture in the presence of phytohemagglutinin (PHA) and 12-O-tetradecanoyl phorbol-13-acetate (TPA), an increase from 1% to 28% HTLV p19+ cells was observed confirming previous findings that HTLV p19 expression was correlated with proliferative activity of the host cells.	Tetradecanoylphorbol Acetate	117-154	interleukin 23 subunit alpha	Homo sapiens	257-260
28414198-9	2017	In contrast, knockdown of swiprosin-1 attenuated high glucose- or PMA-induced HRGECs apoptosis.	Tetradecanoylphorbol Acetate	66-69	EF hand domain containing 2	Mus musculus	26-37
6604035-4	1983	Upon induction of proliferation of these cells by short-term culture in the presence of phytohemagglutinin (PHA) and 12-O-tetradecanoyl phorbol-13-acetate (TPA), an increase from 1% to 28% HTLV p19+ cells was observed confirming previous findings that HTLV p19 expression was correlated with proliferative activity of the host cells.	Tetradecanoylphorbol Acetate	156-159	interleukin 23 subunit alpha	Homo sapiens	194-197
1645358-4	1991	Phorbol myristate acetate (PMA) induced rapid loss of surface TM activity (approximately 8 h) and later increased TM mRNA levels between 4 h and 40 h (maximum at 24 h), resulting in biphasic effects on TM activity.	Tetradecanoylphorbol Acetate	0-25	thrombomodulin	Homo sapiens	114-116
6604035-4	1983	Upon induction of proliferation of these cells by short-term culture in the presence of phytohemagglutinin (PHA) and 12-O-tetradecanoyl phorbol-13-acetate (TPA), an increase from 1% to 28% HTLV p19+ cells was observed confirming previous findings that HTLV p19 expression was correlated with proliferative activity of the host cells.	Tetradecanoylphorbol Acetate	156-159	interleukin 23 subunit alpha	Homo sapiens	257-260
1645358-4	1991	Phorbol myristate acetate (PMA) induced rapid loss of surface TM activity (approximately 8 h) and later increased TM mRNA levels between 4 h and 40 h (maximum at 24 h), resulting in biphasic effects on TM activity.	Tetradecanoylphorbol Acetate	0-25	thrombomodulin	Homo sapiens	114-116
1645358-4	1991	Phorbol myristate acetate (PMA) induced rapid loss of surface TM activity (approximately 8 h) and later increased TM mRNA levels between 4 h and 40 h (maximum at 24 h), resulting in biphasic effects on TM activity.	Tetradecanoylphorbol Acetate	27-30	thrombomodulin	Homo sapiens	62-64
28396116-3	2017	Beta2-adrenergic receptor (beta2AR) agonists were identified as the most potent inhibitors of phorbol myristate acetate-induced tumor necrosis factor-alpha production in rat bone marrow macrophages.	Tetradecanoylphorbol Acetate	94-119	adrenoceptor beta 2	Rattus norvegicus	0-25
28396116-3	2017	Beta2-adrenergic receptor (beta2AR) agonists were identified as the most potent inhibitors of phorbol myristate acetate-induced tumor necrosis factor-alpha production in rat bone marrow macrophages.	Tetradecanoylphorbol Acetate	94-119	adrenoceptor beta 2	Rattus norvegicus	27-34
6411090-1	1983	The addition of low concentrations of phorbol 12-myristate 13-acetate to rabbit neutrophils induces cell aggregation, degranulation, increased oxygen consumption and an increase in the amount of actin associated with the cytoskeleton without a rise in the level of intracellular free calcium as measured using the fluorescent probe quin-2.	Tetradecanoylphorbol Acetate	38-69	actin	Oryctolagus cuniculus	195-200
1645358-4	1991	Phorbol myristate acetate (PMA) induced rapid loss of surface TM activity (approximately 8 h) and later increased TM mRNA levels between 4 h and 40 h (maximum at 24 h), resulting in biphasic effects on TM activity.	Tetradecanoylphorbol Acetate	27-30	thrombomodulin	Homo sapiens	114-116
1645358-4	1991	Phorbol myristate acetate (PMA) induced rapid loss of surface TM activity (approximately 8 h) and later increased TM mRNA levels between 4 h and 40 h (maximum at 24 h), resulting in biphasic effects on TM activity.	Tetradecanoylphorbol Acetate	27-30	thrombomodulin	Homo sapiens	114-116
1645361-11	1991	Finally, the tumor promoter phorbol myristate acetate, an activator of protein kinase C, also increased SC115 cell uPA activity and synergized with RA.	Tetradecanoylphorbol Acetate	28-53	plasminogen activator, urokinase	Mus musculus	115-118
28469194-5	2017	KXS might fulfill this effect by up-regulating the expressions of NGF, BDNF and Trk receptors in hippocampus, which were confirmed by the treatment of corresponding blockers tPA-stop and K252a.	Tetradecanoylphorbol Acetate	174-177	brain derived neurotrophic factor	Mus musculus	71-75
1709244-6	1991	As with normal lymphocytes, cells transfected with the LAM-1 cDNA and chronic lymphocytic leukemia (CLL) cells also shed LAM-1 following phorbol myristate acetate (PMA) exposure.	Tetradecanoylphorbol Acetate	137-162	selectin L	Homo sapiens	55-60
27931797-5	2017	Compared with control littermates, Erbb2del mice remained free of papillomas for a longer time and had significantly reduced tumor burden after application of the 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate multistage chemical carcinogenesis protocol.	Tetradecanoylphorbol Acetate	194-230	erb-b2 receptor tyrosine kinase 2	Mus musculus	35-40
6602780-10	1983	HTLV p19 expression was strongly enhanced in the T-CLL cells induced to proliferate by TPA (66%) and in the continuously growing IL-2-dependent T-CLL cells (82%).	Tetradecanoylphorbol Acetate	87-90	interleukin 23 subunit alpha	Homo sapiens	5-8
1709244-6	1991	As with normal lymphocytes, cells transfected with the LAM-1 cDNA and chronic lymphocytic leukemia (CLL) cells also shed LAM-1 following phorbol myristate acetate (PMA) exposure.	Tetradecanoylphorbol Acetate	137-162	selectin L	Homo sapiens	121-126
27931797-6	2017	Furthermore, tumor cell proliferation was substantially reduced in Erbb2del mice, and loss of ERBB2 also decreased keratinocyte proliferation after 12-O-tetradecanoylphorbol-13-acetate application.	Tetradecanoylphorbol Acetate	148-184	erb-b2 receptor tyrosine kinase 2	Mus musculus	94-99
6298128-5	1983	Prolonged treatment of L12 cells with TPA, a tumor cell promoter, gave rise to L12T cells that synthesize the p53 protein and exhibit a lethal tumor phenotype.	Tetradecanoylphorbol Acetate	38-41	transformation related protein 53, pseudogene	Mus musculus	110-113
1709244-6	1991	As with normal lymphocytes, cells transfected with the LAM-1 cDNA and chronic lymphocytic leukemia (CLL) cells also shed LAM-1 following phorbol myristate acetate (PMA) exposure.	Tetradecanoylphorbol Acetate	164-167	selectin L	Homo sapiens	55-60
1709244-6	1991	As with normal lymphocytes, cells transfected with the LAM-1 cDNA and chronic lymphocytic leukemia (CLL) cells also shed LAM-1 following phorbol myristate acetate (PMA) exposure.	Tetradecanoylphorbol Acetate	164-167	selectin L	Homo sapiens	121-126
28018998-7	2017	We found lower levels of tPA-PAI-1 complexes (6.86 (3.99-10.00) and 9.11 (7.17-13.12), p &lt; 0.001) and higher activity of TAFI (18.61 (15.80-22.58) and 17.03 (14.02-20.02), p &lt; 0.001) and alpha2-antiplasmin (102 (94-109) and 98 (90-106], p = 0.003) in patients compared to controls.	Tetradecanoylphorbol Acetate	25-28	serpin family E member 1	Homo sapiens	29-34
2005114-4	1991	In contrast, phorbol 12-myristate 13-acetate stimulation of pro-TGF-alpha cleavage via activation of protein kinase C did not require extracellular calcium.	Tetradecanoylphorbol Acetate	13-44	LOW QUALITY PROTEIN: protransforming growth factor alpha	Cricetulus griseus	64-73
28013489-1	2017	RSK2 is a serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90RSK; RSKs) family, which regulates cell proliferation and transformation induced by tumor promoters such as epithelial growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate (TPA), and ultraviolet (UV) radiation.	Tetradecanoylphorbol Acetate	222-258	ribosomal protein S6 kinase A1	Homo sapiens	54-77
28013489-1	2017	RSK2 is a serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90RSK; RSKs) family, which regulates cell proliferation and transformation induced by tumor promoters such as epithelial growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate (TPA), and ultraviolet (UV) radiation.	Tetradecanoylphorbol Acetate	222-258	ribosomal protein S6 kinase A1	Homo sapiens	79-85
28013489-1	2017	RSK2 is a serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90RSK; RSKs) family, which regulates cell proliferation and transformation induced by tumor promoters such as epithelial growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate (TPA), and ultraviolet (UV) radiation.	Tetradecanoylphorbol Acetate	260-263	ribosomal protein S6 kinase A1	Homo sapiens	54-77
6300862-0	1983	Tumor promoter 12-O-tetradecanoylphorbol 13-acetate, like epidermal growth factor, stimulates cell proliferation and inhibits differentiation of mouse mammary epithelial cells in culture.	Tetradecanoylphorbol Acetate	15-51	epidermal growth factor	Mus musculus	58-81
6300862-1	1983	12-O-Tetradecanoylphorbol 13-acetate (TPA) is a potent tumor promoter and shares several biological activities of epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	0-36	epidermal growth factor	Mus musculus	114-137
6300862-1	1983	12-O-Tetradecanoylphorbol 13-acetate (TPA) is a potent tumor promoter and shares several biological activities of epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	38-41	epidermal growth factor	Mus musculus	114-137
28013489-1	2017	RSK2 is a serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90RSK; RSKs) family, which regulates cell proliferation and transformation induced by tumor promoters such as epithelial growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate (TPA), and ultraviolet (UV) radiation.	Tetradecanoylphorbol Acetate	260-263	ribosomal protein S6 kinase A1	Homo sapiens	79-85
1705566-6	1991	TNF probably exerts its effect through activation of protein kinase C (PKC) as the TNF effect on G-CSF receptor levels can be mimicked by 12-O-tetradecanoylphorbol-13- acetate.	Tetradecanoylphorbol Acetate	138-175	colony stimulating factor 3 receptor	Homo sapiens	97-111
6602667-3	1983	A partial reversal of the ability of the phorbol ester tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate to reduce EGF binding to the class of high affinity receptors occurred following pre-exposure of cells to FA.	Tetradecanoylphorbol Acetate	70-107	epidermal growth factor	Rattus norvegicus	118-121
6602667-4	1983	The increased binding of EGF induced by FA resulted in a faster rate of degradation of EGF from the culture medium and reversed the inhibition of degradation caused by TPA.	Tetradecanoylphorbol Acetate	168-171	epidermal growth factor	Rattus norvegicus	25-28
1997162-4	1991	Phorbol myristate acetate reduced expression of c-myc, c-myb, and heat shock protein 70 and enhanced those of macrophage-colony-stimulating factor and c-fms.	Tetradecanoylphorbol Acetate	0-25	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	48-53
6319830-8	1983	On the other hand, TPA (after 96 h incubation) significantly reduced cells positive for NAI/34 from 76.0 +/- 5.0 to 30.0 +/- 9.8% and for TdT from 81.7 +/- 6.5 to 17.3 +/- 4.4% and increased OKT11 positive cells from 67.3 +/- 5.5 to 89.0 +/- 2.8% (p less than 0.001).	Tetradecanoylphorbol Acetate	19-22	deoxynucleotidyltransferase, terminal	Mus musculus	138-141
6243065-8	1983	Inspection of Dreiding models showed that the oxygens on C-27, C-3, and C-30 of aplysiatoxin are aligned with the oxygens on C-3, C-4, and C-20 of TPA, respectively.	Tetradecanoylphorbol Acetate	147-150	complement component 4B (Chido blood group)	Mus musculus	130-133
28275112-6	2017	Absence of CLIC1 increased PMA-induced superoxide production by isolated peritoneal neutrophils but dramatically decreased PMA-induced superoxide production by peritoneal macrophages.	Tetradecanoylphorbol Acetate	27-30	chloride intracellular channel 1	Mus musculus	11-16
28275112-6	2017	Absence of CLIC1 increased PMA-induced superoxide production by isolated peritoneal neutrophils but dramatically decreased PMA-induced superoxide production by peritoneal macrophages.	Tetradecanoylphorbol Acetate	123-126	chloride intracellular channel 1	Mus musculus	11-16
28275112-7	2017	CLIC1 is expressed in both neutrophils and macrophages in a peripheral pattern consistent with either plasma membrane or the cortical cytoskeleton in resting cells and redistributes away from the periphery following PMA stimulation in both cell types.	Tetradecanoylphorbol Acetate	216-219	chloride intracellular channel 1	Mus musculus	0-5
1997162-4	1991	Phorbol myristate acetate reduced expression of c-myc, c-myb, and heat shock protein 70 and enhanced those of macrophage-colony-stimulating factor and c-fms.	Tetradecanoylphorbol Acetate	0-25	MYB proto-oncogene, transcription factor	Homo sapiens	55-60
28008134-8	2017	Activating PKC-alpha and EGFR directly with the combination of phorbol 12-myristate 13-acetate (PMA) and EGF potentiated MMP1 gene and protein expression, and cell invasion.	Tetradecanoylphorbol Acetate	63-94	matrix metallopeptidase 1	Homo sapiens	121-125
1846746-3	1991	4 beta-phorbol 12-myristate 13-acetate (PMA) and 1,2-dioctanoyl-sn-glycerol, which directly activate PKC, stimulated the synthesis of PAF.	Tetradecanoylphorbol Acetate	40-43	PCNA clamp associated factor	Homo sapiens	134-137
28286738-5	2017	PMA-induced activation of mTORC1 signaling was partially prevented by treatment with U0126 (a selective inhibitor of MEK1/2) or BIX-02189 (a selective inhibitor of MEK5) and completely blocked with BIM-I (a selective inhibitor of upstream PKC).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 1	Homo sapiens	117-123
27654969-3	2016	Here, we investigated the effect of DHA on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced uPAR expression and the underlying molecular mechanisms in ECV304 human endothelial cells.	Tetradecanoylphorbol Acetate	43-79	plasminogen activator, urokinase receptor	Homo sapiens	94-98
1846746-4	1991	Sphingosine, a long-chain amine that inhibits PKC, blocked both the binding of phorbol esters to monocytes and the synthesis of PAF in response to PMA (half-maximal inhibition at 5 to 10 microM and complete inhibition at 10 to 30 microM sphingosine).	Tetradecanoylphorbol Acetate	147-150	PCNA clamp associated factor	Homo sapiens	128-131
27654969-3	2016	Here, we investigated the effect of DHA on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced uPAR expression and the underlying molecular mechanisms in ECV304 human endothelial cells.	Tetradecanoylphorbol Acetate	81-84	plasminogen activator, urokinase receptor	Homo sapiens	94-98
1705509-2	1991	Three out of three anti-CD5 mAb, 10.2, OKT1 and anti-Leu-1 induced vigorous proliferation of purified T cells in the presence of 1.6 nM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	136-167	CD5 molecule	Homo sapiens	24-27
27654969-4	2016	DHA concentration-dependently inhibited TPA-induced uPAR.	Tetradecanoylphorbol Acetate	40-43	plasminogen activator, urokinase receptor	Homo sapiens	52-56
27654969-5	2016	Specific inhibitors and mutagenesis studies showed that PKCdelta, JNK1/2, Erk1/2, NF-kappaB, and AP-1 were critical for TPA-induced uPAR expression.	Tetradecanoylphorbol Acetate	120-123	plasminogen activator, urokinase receptor	Homo sapiens	132-136
6293870-0	1982	Involvement of calcium, calmodulin and phospholipase A in the alteration of membrane dynamics and superoxide production of human neutrophils stimulated by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	155-180	phospholipase A and acyltransferase 1	Homo sapiens	39-54
1705509-2	1991	Three out of three anti-CD5 mAb, 10.2, OKT1 and anti-Leu-1 induced vigorous proliferation of purified T cells in the presence of 1.6 nM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	136-167	CD5 molecule	Homo sapiens	53-58
1705509-2	1991	Three out of three anti-CD5 mAb, 10.2, OKT1 and anti-Leu-1 induced vigorous proliferation of purified T cells in the presence of 1.6 nM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	169-172	CD5 molecule	Homo sapiens	24-27
1705509-2	1991	Three out of three anti-CD5 mAb, 10.2, OKT1 and anti-Leu-1 induced vigorous proliferation of purified T cells in the presence of 1.6 nM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	169-172	CD5 molecule	Homo sapiens	53-58
27350581-4	2016	In CHO-K1 cells stably transfected with the hH3R445 direct PKC activation by phorbol 12-myristate 13-acetate (TPA, 200 nM) abolished H3R-mediated inhibition of forskolin-stimulated cAMP accumulation.	Tetradecanoylphorbol Acetate	77-108	histamine receptor H3	Homo sapiens	44-48
2050272-4	1991	Other agents, such as phorbol 12-myristate 13-acetate (TPA) (0.5 microM) and vanadate (2 mM) evoked only part of the insulin effect on glucose uptake (50% and 65%, respectively), without being additive to insulin.	Tetradecanoylphorbol Acetate	22-53	insulin S homeolog	Xenopus laevis	117-124
27350581-4	2016	In CHO-K1 cells stably transfected with the hH3R445 direct PKC activation by phorbol 12-myristate 13-acetate (TPA, 200 nM) abolished H3R-mediated inhibition of forskolin-stimulated cAMP accumulation.	Tetradecanoylphorbol Acetate	77-108	histamine receptor H3	Homo sapiens	45-48
27350581-4	2016	In CHO-K1 cells stably transfected with the hH3R445 direct PKC activation by phorbol 12-myristate 13-acetate (TPA, 200 nM) abolished H3R-mediated inhibition of forskolin-stimulated cAMP accumulation.	Tetradecanoylphorbol Acetate	110-113	histamine receptor H3	Homo sapiens	44-48
27350581-4	2016	In CHO-K1 cells stably transfected with the hH3R445 direct PKC activation by phorbol 12-myristate 13-acetate (TPA, 200 nM) abolished H3R-mediated inhibition of forskolin-stimulated cAMP accumulation.	Tetradecanoylphorbol Acetate	110-113	histamine receptor H3	Homo sapiens	45-48
27350581-7	2016	Pre-incubation with TPA or ATP reduced H3R-mediated stimulation of [(35)S]-GTPgammaS binding to membranes from CHO-K1-hH3R445 cells by 39.7 and 54.2 %, respectively, with no change in the agonist potency, and the effect was prevented by either Ro-31-8220 or Go-6976.	Tetradecanoylphorbol Acetate	20-23	histamine receptor H3	Homo sapiens	39-42
2050272-4	1991	Other agents, such as phorbol 12-myristate 13-acetate (TPA) (0.5 microM) and vanadate (2 mM) evoked only part of the insulin effect on glucose uptake (50% and 65%, respectively), without being additive to insulin.	Tetradecanoylphorbol Acetate	55-58	insulin S homeolog	Xenopus laevis	117-124
2050272-4	1991	Other agents, such as phorbol 12-myristate 13-acetate (TPA) (0.5 microM) and vanadate (2 mM) evoked only part of the insulin effect on glucose uptake (50% and 65%, respectively), without being additive to insulin.	Tetradecanoylphorbol Acetate	55-58	insulin S homeolog	Xenopus laevis	205-212
2051897-4	1991	He-PC2 inhibited TPA-induced depletion of PKC and TPA-stimulated phosphorylation of cellular proteins in HL60 cells.	Tetradecanoylphorbol Acetate	17-20	chromobox 4	Homo sapiens	3-6
27531070-4	2016	In contrast to the decreased tyrosine phosphorylation, Phos-tag Western blot analysis revealed that TPA induced phosphorylation of ErbB2 in an ERK-dependent manner.	Tetradecanoylphorbol Acetate	100-103	EPH receptor B2	Homo sapiens	143-146
2051897-4	1991	He-PC2 inhibited TPA-induced depletion of PKC and TPA-stimulated phosphorylation of cellular proteins in HL60 cells.	Tetradecanoylphorbol Acetate	50-53	chromobox 4	Homo sapiens	3-6
2051897-5	1991	TPA-induced differentiation of HL60 cells was also inhibited by He-PC2, and this inhibition was synergistic or additive to the effects of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), a PKC inhibitor.	Tetradecanoylphorbol Acetate	0-3	chromobox 4	Homo sapiens	67-70
27509024-5	2016	Under TPA or vehicle treatment, MDM2 expression was significantly reduced in exercised mice when compared with sedentary control.	Tetradecanoylphorbol Acetate	6-9	transformed mouse 3T3 cell double minute 2	Mus musculus	32-36
27509024-8	2016	There was a synergy effect between exercise and TPA on the decreased MDM2 and increased p53, but not p53-transcripted proteins.	Tetradecanoylphorbol Acetate	48-51	transformed mouse 3T3 cell double minute 2	Mus musculus	69-73
27509024-8	2016	There was a synergy effect between exercise and TPA on the decreased MDM2 and increased p53, but not p53-transcripted proteins.	Tetradecanoylphorbol Acetate	48-51	transformation related protein 53, pseudogene	Mus musculus	88-91
1901643-3	1991	This fragment contains a sequence with a high degree of similarity to the binding site for the transcription factor activator protein-1 (AP-1) and indeed, the AP-1 sequence of this fragment is necessary but not sufficient for the maximal response to phorbol 12-myristate 13-acetate (phorbol) or interleukin-1.	Tetradecanoylphorbol Acetate	250-281	interleukin 1 alpha	Homo sapiens	295-308
27327083-5	2016	We also found a significant response of TBX15 to TNF-alpha activation of the NF-kappaB pathway using five cancer cell lines, and similar results were obtained when NF-kappaB was activated with PMA/ionomycin.	Tetradecanoylphorbol Acetate	193-196	T-box transcription factor 15	Homo sapiens	40-45
1845978-0	1991	Phorbol 12-myristate 13-acetate inhibits granulocyte-macrophage colony stimulating factor-induced protein tyrosine phosphorylation in a human factor-dependent hematopoietic cell line.	Tetradecanoylphorbol Acetate	0-31	colony stimulating factor 2	Homo sapiens	41-89
27175590-4	2016	In this study, H68 fibroblasts, THP-1 and phorbol-12-myristate-13-acetate (PMA)-treated THP-1 (PMA-THP-1) cells were incubated with conditioned media of control (control-CM) and 14-3-3sigma-overepxressing cells (14-3-3sigma-CM), followed by co-culture with HCC cells.	Tetradecanoylphorbol Acetate	75-78	stratifin	Homo sapiens	178-189
1845978-3	1991	GM-CSF-induced proliferation of MO7 cells was found to be inhibited by two activators of protein kinase C, phorbol 12-myristate 13-acetate (PMA) and bryostatin-1.	Tetradecanoylphorbol Acetate	107-138	colony stimulating factor 2	Homo sapiens	0-6
27175590-4	2016	In this study, H68 fibroblasts, THP-1 and phorbol-12-myristate-13-acetate (PMA)-treated THP-1 (PMA-THP-1) cells were incubated with conditioned media of control (control-CM) and 14-3-3sigma-overepxressing cells (14-3-3sigma-CM), followed by co-culture with HCC cells.	Tetradecanoylphorbol Acetate	75-78	stratifin	Homo sapiens	212-223
1845978-4	1991	PMA did not affect surface expression or affinity of the GM-CSF receptor but significantly inhibited GM-CSF- or IL-3-induced tyrosine phosphorylation of p93 and p70.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 2	Homo sapiens	101-107
1845978-4	1991	PMA did not affect surface expression or affinity of the GM-CSF receptor but significantly inhibited GM-CSF- or IL-3-induced tyrosine phosphorylation of p93 and p70.	Tetradecanoylphorbol Acetate	0-3	interleukin 3	Homo sapiens	112-116
1845978-5	1991	In contrast, PMA augmented GM-CSF-induced tyrosine phosphorylation of another protein, p42.	Tetradecanoylphorbol Acetate	13-16	colony stimulating factor 2	Homo sapiens	27-33
27035791-12	2016	Our findings revealed that the anti-invasive effects of Rev-AuNPs in response to TPA-stimulation were mediated by the suppression of MMP-9, COX-2, NF-kappaB, AP-1, PI3K/Akt and ERK and/or the activation of HO-1 signaling cascades.	Tetradecanoylphorbol Acetate	81-84	heme oxygenase 1	Homo sapiens	206-210
27036017-0	2016	Docosahexaenoic acid inhibits 12-O-tetradecanoylphorbol-13- acetate-induced fascin-1-dependent breast cancer cell migration by suppressing the PKCdelta- and Wnt-1/beta-catenin-mediated pathways.	Tetradecanoylphorbol Acetate	30-67	catenin beta 1	Homo sapiens	163-175
1845978-5	1991	In contrast, PMA augmented GM-CSF-induced tyrosine phosphorylation of another protein, p42.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase 20	Homo sapiens	87-90
27036017-3	2016	TPA dose- and time-dependently increased PKCdelta and STAT3alpha activation and GSK3beta phosphorylation; up-regulated Wnt-1, beta-catenin, and STAT3alpha expression; and increased the nuclear translocation of beta-catenin and STAT3alpha.	Tetradecanoylphorbol Acetate	0-3	catenin beta 1	Homo sapiens	126-138
1846099-1	1991	In GH4C1 cells, TRH and the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), have been shown to activate Na+/H+ exchange, probably via stimulation of protein kinase C. In the present study, the dependence of changes in intracellular pH (pHi) on transients in the cytosolic free calcium concentration [( Ca2+]i) was investigated using BCECF and fura-2, respectively.	Tetradecanoylphorbol Acetate	81-84	glucose-6-phosphate isomerase	Rattus norvegicus	247-250
27036017-3	2016	TPA dose- and time-dependently increased PKCdelta and STAT3alpha activation and GSK3beta phosphorylation; up-regulated Wnt-1, beta-catenin, and STAT3alpha expression; and increased the nuclear translocation of beta-catenin and STAT3alpha.	Tetradecanoylphorbol Acetate	0-3	catenin beta 1	Homo sapiens	210-222
27036017-5	2016	WP1066, a STAT3 inhibitor, suppressed TPA-induced STAT3alpha DNA binding activity and beta-catenin expression.	Tetradecanoylphorbol Acetate	38-41	catenin beta 1	Homo sapiens	86-98
27036017-6	2016	Knockdown of beta-catenin attenuated TPA-induced fascin-1 and STAT3alpha expression as well as cell migration.	Tetradecanoylphorbol Acetate	37-40	catenin beta 1	Homo sapiens	13-25
27036017-10	2016	Our results demonstrated that TPA-induced migration is likely associated with the PKCdelta and Wnt-1 pathways, which lead to STAT3alpha activation, GSK3beta inactivation, and beta-catenin increase and up-regulation of fascin-1 expression.	Tetradecanoylphorbol Acetate	30-33	catenin beta 1	Homo sapiens	175-187
1846099-7	1991	TPA induced a rise in pHi, which was further enhanced by TRH, but not ionomycin.	Tetradecanoylphorbol Acetate	0-3	glucose-6-phosphate isomerase	Rattus norvegicus	22-25
2069924-8	1991	In the conditioned culture media from LPS-PMA-stimulated macrophages, the levels of both IL-1 and TNF peaked on postsurgical days 3 and 14.	Tetradecanoylphorbol Acetate	42-45	tumor necrosis factor	Oryctolagus cuniculus	98-101
27043542-3	2016	In the present study, we found that exogenous cell-permeable short-chain C2 ceramide inhibits phorbol myristate acetate (PMA)-induced MMP-1, -3, and -9 gene expressions in U87MG and U373MG human astroglioma cells.	Tetradecanoylphorbol Acetate	94-119	matrix metallopeptidase 1	Homo sapiens	134-151
27043542-3	2016	In the present study, we found that exogenous cell-permeable short-chain C2 ceramide inhibits phorbol myristate acetate (PMA)-induced MMP-1, -3, and -9 gene expressions in U87MG and U373MG human astroglioma cells.	Tetradecanoylphorbol Acetate	121-124	matrix metallopeptidase 1	Homo sapiens	134-151
26712312-13	2016	However, NET production in response to phorbol 12-myristate 13-acetate or platelet activating factor was normal in neutrophils from two independent NE-deficient mouse lines, and in NE(-/-) SB1(-/-) as compared with SB1(-/-) neutrophils.	Tetradecanoylphorbol Acetate	39-70	elastase, neutrophil expressed	Mus musculus	9-11
27610138-3	2016	In groups 1 and 4, by post-CLI 18 h and day 14, circulating EPC (C-kit+/CD31+, Sca-1+/KDR+) levels were highest in CLI-tPA subgroup.	Tetradecanoylphorbol Acetate	119-122	transcription factor 21	Mus musculus	60-63
27610138-8	2016	In conclusion, tPA-MMP-9 axis plays a crucial role in EPC mobilization and angiogenesis in experimental CLI.	Tetradecanoylphorbol Acetate	15-18	transcription factor 21	Mus musculus	54-57
26653982-8	2015	Phorbol-12-myristate-13-acetate (PMA)-stimulated and gamma-irradiated U937 (human monocyte) cells induced a bystander response in non-irradiated A549 (lung carcinoma) cells as shown by decreased survival and increased gamma-H2AX and p-ATM foci.	Tetradecanoylphorbol Acetate	0-31	ATM serine/threonine kinase	Homo sapiens	235-238
26653982-8	2015	Phorbol-12-myristate-13-acetate (PMA)-stimulated and gamma-irradiated U937 (human monocyte) cells induced a bystander response in non-irradiated A549 (lung carcinoma) cells as shown by decreased survival and increased gamma-H2AX and p-ATM foci.	Tetradecanoylphorbol Acetate	33-36	ATM serine/threonine kinase	Homo sapiens	235-238
26516703-7	2015	Using an IL-32theta stable expression system in leukemia cell lines, we found that IL-32theta attenuated phorbol 12-myristate 13-acetate (PMA)-induced TNF-alpha production.	Tetradecanoylphorbol Acetate	105-136	interleukin 32	Homo sapiens	9-14
26516703-7	2015	Using an IL-32theta stable expression system in leukemia cell lines, we found that IL-32theta attenuated phorbol 12-myristate 13-acetate (PMA)-induced TNF-alpha production.	Tetradecanoylphorbol Acetate	105-136	interleukin 32	Homo sapiens	83-88
26516703-7	2015	Using an IL-32theta stable expression system in leukemia cell lines, we found that IL-32theta attenuated phorbol 12-myristate 13-acetate (PMA)-induced TNF-alpha production.	Tetradecanoylphorbol Acetate	138-141	interleukin 32	Homo sapiens	9-14
26516703-7	2015	Using an IL-32theta stable expression system in leukemia cell lines, we found that IL-32theta attenuated phorbol 12-myristate 13-acetate (PMA)-induced TNF-alpha production.	Tetradecanoylphorbol Acetate	138-141	interleukin 32	Homo sapiens	83-88
26319153-5	2015	The treatment of neutrophils with PMA induced phosphorylation of Ser345 on p47(phox), a cytosolic component of NADPH oxidase.	Tetradecanoylphorbol Acetate	34-37	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	75-78
26269597-8	2015	In addition to metabolic effects, PMA treatment also translocated PKM2, but not PKR, into nucleus.	Tetradecanoylphorbol Acetate	34-37	pyruvate kinase M1/2	Homo sapiens	66-70
26375594-8	2015	In vitro stimulation of peripheral blood lymphocytes with ovalbumin followed by stimulation with PMA/ionomycin allowed the identification by flow cytometry of CD4+ T cells producing either IL-17A, IFN-gamma, or both cytokines.	Tetradecanoylphorbol Acetate	97-100	interleukin 17A	Bos taurus	189-195
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	Tetradecanoylphorbol Acetate	56-59	epidermal growth factor receptor	Mus musculus	98-102
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	Tetradecanoylphorbol Acetate	56-59	Rous sarcoma oncogene	Mus musculus	111-114
26100520-7	2015	Furthermore, NF-kappaB, Egr-1, and AP-1 DNA binding activities after TPA treatment were dramatically decreased by the combination of ursolic acid + resveratrol.	Tetradecanoylphorbol Acetate	69-72	early growth response 1	Mus musculus	24-29
26118976-8	2015	RESULTS: Compared with saline, tPA significantly increased the infarct size in TAFI-/- mice (p&lt;0.05).	Tetradecanoylphorbol Acetate	31-34	carboxypeptidase B2 (plasma)	Mus musculus	79-83
26118976-10	2015	A positive signal for apoptosis and degenerating neurons was observed in the infarct area, being significantly higher in tPA treated TAFI-/- mice (p&lt;0.05).	Tetradecanoylphorbol Acetate	121-124	carboxypeptidase B2 (plasma)	Mus musculus	133-137
26133397-9	2015	Thus, these data suggest that despite its characterised role in promoting cellular quiescence, R-Ras is pro-tumourigenic in the DMBA/TPA tumour model and important for the inflammatory response to DMBA/TPA treatment.	Tetradecanoylphorbol Acetate	133-136	RAS related	Homo sapiens	95-100
26133397-9	2015	Thus, these data suggest that despite its characterised role in promoting cellular quiescence, R-Ras is pro-tumourigenic in the DMBA/TPA tumour model and important for the inflammatory response to DMBA/TPA treatment.	Tetradecanoylphorbol Acetate	202-205	RAS related	Homo sapiens	95-100
24832356-3	2015	METHODS: Synovial fibroblast cells (HIG-82) were cultured in vitro and induced by phorbol-12-myristate acetate (PMA) to stimulate the expression of matrix metalloproteinase (MMPs) and pro-inflammatory cytokines.	Tetradecanoylphorbol Acetate	112-115	matrix metallopeptidase 1	Homo sapiens	174-178
25617690-1	2015	Plasminogen activator inhibitor-1 (PAI-1), the primary inhibitor of urokinase-and tissue-type plasminogen activators (uPA and tPA), is an injury-response gene implicated in the development of tissue fibrosis and cardiovascular disease.	Tetradecanoylphorbol Acetate	126-129	serpin family E member 1	Homo sapiens	0-33
25617690-1	2015	Plasminogen activator inhibitor-1 (PAI-1), the primary inhibitor of urokinase-and tissue-type plasminogen activators (uPA and tPA), is an injury-response gene implicated in the development of tissue fibrosis and cardiovascular disease.	Tetradecanoylphorbol Acetate	126-129	serpin family E member 1	Homo sapiens	35-40
25727244-0	2015	SCF/c-kit signaling is required in 12-O-tetradecanoylphorbol-13-acetate-induced migration and differentiation of hair follicle melanocytes for epidermal pigmentation.	Tetradecanoylphorbol Acetate	35-71	kit ligand	Mus musculus	0-3
25727244-0	2015	SCF/c-kit signaling is required in 12-O-tetradecanoylphorbol-13-acetate-induced migration and differentiation of hair follicle melanocytes for epidermal pigmentation.	Tetradecanoylphorbol Acetate	35-71	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	4-9
25727244-8	2015	At the molecular level, TPA treatment induced robust expression of stem cell factor (SCF) in keratinocytes and c-kit in melanoblasts and melanocytes.	Tetradecanoylphorbol Acetate	24-27	kit ligand	Mus musculus	67-83
25727244-8	2015	At the molecular level, TPA treatment induced robust expression of stem cell factor (SCF) in keratinocytes and c-kit in melanoblasts and melanocytes.	Tetradecanoylphorbol Acetate	24-27	kit ligand	Mus musculus	85-88
25727244-8	2015	At the molecular level, TPA treatment induced robust expression of stem cell factor (SCF) in keratinocytes and c-kit in melanoblasts and melanocytes.	Tetradecanoylphorbol Acetate	24-27	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	111-116
25727244-11	2015	SCF/c-kit signaling was required for TPA-induced migration and differentiation of hair follicle melanocytes.	Tetradecanoylphorbol Acetate	37-40	kit ligand	Mus musculus	0-3
25727244-11	2015	SCF/c-kit signaling was required for TPA-induced migration and differentiation of hair follicle melanocytes.	Tetradecanoylphorbol Acetate	37-40	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	4-9
25649981-0	2015	15-Hydroxyeicosatetraenoic Acid Inhibits Phorbol-12-Myristate-13-Acetate-Induced MUC5AC Expression in NCI-H292 Respiratory Epithelial Cells.	Tetradecanoylphorbol Acetate	41-72	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	81-87
25915860-10	2015	Taken together, these results suggest that TPA is able to induce VIL2 V1 over-expression in ESCC cells by activating MEK/ERK1/2 signaling and increasing binding of Sp1 and c-Jun to the TRE of the VIL2 V1 promoter, and that VIL2 is an important TPA-induced effector.	Tetradecanoylphorbol Acetate	244-247	ezrin	Homo sapiens	196-200
25871385-6	2015	Furthermore, in response to DMBA/TPA, the Dsg2/Ptc1+/lacZ mice developed squamous lessons earlier than the WT, Ptc1(+/lacZ), and Inv-Dsg2 littermates.	Tetradecanoylphorbol Acetate	33-36	desmoglein 2	Mus musculus	42-46
25871385-6	2015	Furthermore, in response to DMBA/TPA, the Dsg2/Ptc1+/lacZ mice developed squamous lessons earlier than the WT, Ptc1(+/lacZ), and Inv-Dsg2 littermates.	Tetradecanoylphorbol Acetate	33-36	desmoglein 2	Mus musculus	133-137
25871385-7	2015	Additionally, DMBA/TPA induced BCC formation in all mice harboring the Ptc1(+/lacZ) gene and the presence of Dsg2 in Dsg2/Ptc1(+/lacZ) mice doubled the BCC tumor burden.	Tetradecanoylphorbol Acetate	19-22	desmoglein 2	Mus musculus	109-113
25740823-5	2015	In contrast, deletion of epidermal Rictor prior to initiation in DMBA/TPA chemical carcinogenesis was sufficient to dramatically delay tumor development and resulted in reduced tumor number and size compared with control groups.	Tetradecanoylphorbol Acetate	70-73	RPTOR independent companion of MTOR complex 2	Homo sapiens	35-41
25615797-1	2015	PAI-1, a glycoprotein from the serpin family and the main inhibitor of tPA and uPA, plays an essential role in the regulation of intra and extravascular fibrinolysis by inhibiting the formation of plasmin from plasminogen.	Tetradecanoylphorbol Acetate	71-74	serpin family E member 1	Homo sapiens	0-21
6982822-1	1982	Splenocytes of nu/nu mice treated with serum thymic factor (FTS) for 3 or more days followed by stimulation with either phorbol myristate acetate (PMA) or concanavalin A (Con A) produced interleukin 2 (IL 2) as determined in two indicator systems, namely, support of growth of IL 2-dependent T cells and promotion of Con A-initiated mitogenesis of thymocytes.	Tetradecanoylphorbol Acetate	120-145	interleukin 2	Mus musculus	187-200
6982822-1	1982	Splenocytes of nu/nu mice treated with serum thymic factor (FTS) for 3 or more days followed by stimulation with either phorbol myristate acetate (PMA) or concanavalin A (Con A) produced interleukin 2 (IL 2) as determined in two indicator systems, namely, support of growth of IL 2-dependent T cells and promotion of Con A-initiated mitogenesis of thymocytes.	Tetradecanoylphorbol Acetate	120-145	interleukin 2	Mus musculus	202-206
6982822-1	1982	Splenocytes of nu/nu mice treated with serum thymic factor (FTS) for 3 or more days followed by stimulation with either phorbol myristate acetate (PMA) or concanavalin A (Con A) produced interleukin 2 (IL 2) as determined in two indicator systems, namely, support of growth of IL 2-dependent T cells and promotion of Con A-initiated mitogenesis of thymocytes.	Tetradecanoylphorbol Acetate	147-150	interleukin 2	Mus musculus	187-200
6982822-1	1982	Splenocytes of nu/nu mice treated with serum thymic factor (FTS) for 3 or more days followed by stimulation with either phorbol myristate acetate (PMA) or concanavalin A (Con A) produced interleukin 2 (IL 2) as determined in two indicator systems, namely, support of growth of IL 2-dependent T cells and promotion of Con A-initiated mitogenesis of thymocytes.	Tetradecanoylphorbol Acetate	147-150	interleukin 2	Mus musculus	202-206
6982822-1	1982	Splenocytes of nu/nu mice treated with serum thymic factor (FTS) for 3 or more days followed by stimulation with either phorbol myristate acetate (PMA) or concanavalin A (Con A) produced interleukin 2 (IL 2) as determined in two indicator systems, namely, support of growth of IL 2-dependent T cells and promotion of Con A-initiated mitogenesis of thymocytes.	Tetradecanoylphorbol Acetate	147-150	interleukin 2	Mus musculus	277-281
6813857-1	1982	An interleukin 2-independent murine T cell line (BFS) was isolated that produced immune interferon after stimulation with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	122-153	interleukin 2	Mus musculus	3-16
6288114-0	1982	Effect of retinoic acid and 12-O-tetradecanoyl phorbol-13-acetate on the binding of epidermal growth factor to its cellular receptors.	Tetradecanoylphorbol Acetate	28-65	epidermal growth factor	Mus musculus	84-107
6288114-5	1982	TPA inhibited binding of EGF to the cells by abolishing the binding to the high affinity sites, whereas retinoic acid, in the presence of TPA, enhanced it by increasing the number of the low affinity sites.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor	Mus musculus	25-28
6753485-5	1982	LIF production of the Mo-depleted cells could be fully reconstituted by addition of conditioned media obtained from Mo cultures, especially if stimulated by the Mo-activating agent, phorbol myristate acetate.	Tetradecanoylphorbol Acetate	182-207	LIF interleukin 6 family cytokine	Homo sapiens	0-3
6284358-0	1982	Phorbol diester and epidermal growth factor receptors in 12-O-tetradecanoylphorbol-13-acetate-resistant and -sensitive mouse epidermal cells.	Tetradecanoylphorbol Acetate	57-93	epidermal growth factor	Mus musculus	20-43
6284358-7	1982	Lack of EGF receptors may account for TPA mitogen resistance in at least three of four resistant variants.	Tetradecanoylphorbol Acetate	38-41	epidermal growth factor	Mus musculus	8-11
6284358-8	1982	The TPA-induced EGF binding decrease occurs in both sensitive and resistant variants.	Tetradecanoylphorbol Acetate	4-7	epidermal growth factor	Mus musculus	16-19
6952230-2	1982	When [35S]methionine-labeled proteins synthesized after the addition of TPA were analyzed by one- or two-dimensional polyacrylamide gel electrophoresis, the increased synthesis of a 32,000-dalton protein (designated p32) was noted as one of the earliest changes.	Tetradecanoylphorbol Acetate	72-75	complement component 1, q subcomponent binding protein	Mus musculus	216-219
6952230-10	1982	The increased rate of the synthesis of p32 was considered to be regulated at the transcriptional level, because the increase in synthesis of p32 was inhibited by actinomycin D, and TPA-treated cells were shown to contain a higher level of translatable mRNA coding for p32 than do control cells.	Tetradecanoylphorbol Acetate	181-184	complement component 1, q subcomponent binding protein	Mus musculus	39-42
6952230-10	1982	The increased rate of the synthesis of p32 was considered to be regulated at the transcriptional level, because the increase in synthesis of p32 was inhibited by actinomycin D, and TPA-treated cells were shown to contain a higher level of translatable mRNA coding for p32 than do control cells.	Tetradecanoylphorbol Acetate	181-184	complement component 1, q subcomponent binding protein	Mus musculus	141-144
6952230-10	1982	The increased rate of the synthesis of p32 was considered to be regulated at the transcriptional level, because the increase in synthesis of p32 was inhibited by actinomycin D, and TPA-treated cells were shown to contain a higher level of translatable mRNA coding for p32 than do control cells.	Tetradecanoylphorbol Acetate	181-184	complement component 1, q subcomponent binding protein	Mus musculus	141-144
7116571-5	1982	A distinct dose-dependent increase in hepatic ODC activity could be observed at 4 h following the injection of increasing amounts of TPA (0-100 microgram, i.p.).	Tetradecanoylphorbol Acetate	133-136	ornithine decarboxylase 1	Rattus norvegicus	46-49
7116571-8	1982	Both 200 micrograms and 500 micrograms TPA produced less of an elevation in hepatic ODC activity than did the optimal dose of 100 micrograms.	Tetradecanoylphorbol Acetate	39-42	ornithine decarboxylase 1	Rattus norvegicus	84-87
6975322-1	1981	A variant line of murine T lymphoma EL4 produces high levels of the lymphokine Interleukin 2 (IL 2) when it is stimulated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	127-152	interleukin 2	Mus musculus	79-92
6975322-1	1981	A variant line of murine T lymphoma EL4 produces high levels of the lymphokine Interleukin 2 (IL 2) when it is stimulated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	127-152	interleukin 2	Mus musculus	94-98
6975322-6	1981	The IL 2 produced by injected oocytes from a given preparation of mRNA is about 1% of the amount produced by the EL4 cells stimulated originally with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	150-175	interleukin 2	Mus musculus	4-8
6975322-8	1981	We conclude that IL 2 is essentially protein in nature, that the protein is coded for by poly A+ mRNA, and that the amount of this mRNA increases significantly after stimulation of the variant EL4 cells with the inducer phorbol myristate acetate.	Tetradecanoylphorbol Acetate	220-245	interleukin 2	Mus musculus	17-21
6118206-4	1981	TPA and EGF each produced characteristic changes in the morphology of ACR-SF colonies.	Tetradecanoylphorbol Acetate	0-3	acrosin	Homo sapiens	70-73
6266654-0	1981	Growth state-dependent alterations in the ability of 12-O-tetradecanoylphorbol-13-acetate to increase ornithine decarboxylase activity in Reuber h35 Hepatoma cells.	Tetradecanoylphorbol Acetate	53-89	ornithine decarboxylase 1	Rattus norvegicus	102-125
6259217-5	1981	Like EGF, the potent phorbol ester 12-O-tetradecanoyl-13-phorbol acetate (TPA) stimulates protein synthesis as indicated by a twofold increase in [(3)H]leucine incorporation into protein after 24 h in TPA.	Tetradecanoylphorbol Acetate	74-77	epidermal growth factor	Homo sapiens	5-8
6259217-9	1981	Furthermore, TPA inhibits cell division in media with or without serum, and prevents growth stimulation by EGF.	Tetradecanoylphorbol Acetate	13-16	epidermal growth factor	Homo sapiens	107-110
7430708-2	1980	Ornithine decarboxylase (OCD; EC 4.1.1.17) activity is induced in dorsal rat skin by either application of the tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate (TPA) or by hair plucking.	Tetradecanoylphorbol Acetate	165-168	ornithine decarboxylase 1	Rattus norvegicus	0-23
7430708-3	1980	In TPA-treated rat skin, ODC activity does not rise above controls until 3 hr posttreatment.	Tetradecanoylphorbol Acetate	3-6	ornithine decarboxylase 1	Rattus norvegicus	25-28
7430708-10	1980	Stimulation of ODC by hair plucking is insensitive to indomethacin administration but the TPA-response is inhibited 74%.	Tetradecanoylphorbol Acetate	90-93	ornithine decarboxylase 1	Rattus norvegicus	15-18
7430708-14	1980	These results indicate that the tumor promoter, TPA, and the more physiological stimulus, hair plucking, stimulate skin ornithine decarboxylase activity by different mechanisms.	Tetradecanoylphorbol Acetate	48-51	ornithine decarboxylase 1	Rattus norvegicus	120-143
315558-1	1979	In previous studies we demonstrated that the tumor-promoting agent 12-O-tetradecanoyl phorbol 13-acetate (TPA) and related macrocyclic diterpenes are potent inhibitors of the binding of epidermal growth factor (EGF) to its cell surface receptors in HeLa cells.	Tetradecanoylphorbol Acetate	106-109	epidermal growth factor	Homo sapiens	211-214
315558-4	1979	In HeLa cells TPA inhibits the initial binding of EGF and also accelerates the loss of previously bound EGF from cells.	Tetradecanoylphorbol Acetate	14-17	epidermal growth factor	Homo sapiens	50-53
315558-4	1979	In HeLa cells TPA inhibits the initial binding of EGF and also accelerates the loss of previously bound EGF from cells.	Tetradecanoylphorbol Acetate	14-17	epidermal growth factor	Homo sapiens	104-107
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	4-7	epidermal growth factor	Homo sapiens	18-21
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	4-7	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	4-7	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	4-7	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	18-21
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	18-21
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	18-21
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	18-21
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	112-115
315558-6	1979	The TPA effect on EGF receptors is mediated by a highly temperature-dependent process because TPA inhibition of EGF binding, and TPA-induced release of prebound EGF, are much greater at 37 degrees C or 22 degrees C than at 4 degrees C. A curious feature is that when cells are grown in TPA for one or more days they escape or become refractory to TPA inhibition of EGF binding.	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	112-115
315558-7	1979	Taken together, these results suggest that TPA inhibits EGF binding not by binding directly to the "active site" of the EGF receptor but by indirectly altering the conformation or inducing the clustering of EGF receptors.	Tetradecanoylphorbol Acetate	43-46	epidermal growth factor	Homo sapiens	56-59
315558-7	1979	Taken together, these results suggest that TPA inhibits EGF binding not by binding directly to the "active site" of the EGF receptor but by indirectly altering the conformation or inducing the clustering of EGF receptors.	Tetradecanoylphorbol Acetate	43-46	epidermal growth factor	Homo sapiens	120-123
315558-7	1979	Taken together, these results suggest that TPA inhibits EGF binding not by binding directly to the "active site" of the EGF receptor but by indirectly altering the conformation or inducing the clustering of EGF receptors.	Tetradecanoylphorbol Acetate	43-46	epidermal growth factor	Homo sapiens	120-123
16068160-1	1979	TPA (12-O-tetradecanoyl-phorbol-13-acetate) reversibly inhibits the binding of (125)I-labelled epidermal growth factor (EGF) to treated mouse and human cells, but does not affect the binding of various other ligands to their membrane receptors.	Tetradecanoylphorbol Acetate	5-42	epidermal growth factor	Mus musculus	120-123
829182-1	1976	A cytological map of the terminal points of the asynapsis (TPA) has been composed for X, 2 (L, R) and 3 (L, R) salivary gland polytene chromosomes of the third instar larvae of the wild type outbred line K-1 Drosophila melanogaster.	Tetradecanoylphorbol Acetate	59-62	x2	Drosophila melanogaster	86-103
33953303-5	2021	In a cell-based assay using Adam10/17 double-knockout mouse embryonic fibroblasts (Adam10/17-/- mEFs) exogenously expressing each of these mutants, phorbol 12-myristate 13-acetate-stimulated shedding was strongly reduced compared with wild-type ADAM17.	Tetradecanoylphorbol Acetate	148-179	a disintegrin and metallopeptidase domain 10	Mus musculus	28-34
33953303-5	2021	In a cell-based assay using Adam10/17 double-knockout mouse embryonic fibroblasts (Adam10/17-/- mEFs) exogenously expressing each of these mutants, phorbol 12-myristate 13-acetate-stimulated shedding was strongly reduced compared with wild-type ADAM17.	Tetradecanoylphorbol Acetate	148-179	a disintegrin and metallopeptidase domain 10	Mus musculus	83-89
33349924-9	2021	The patient responded well to anti-TNFalpha treatment, which may be linked to the capacity of TNFalpha to induce GM-CSF in PMA-treated PBMCs, while GM-CSF itself only induced dose-dependent IL-1Ra production.	Tetradecanoylphorbol Acetate	123-126	colony stimulating factor 2	Homo sapiens	113-119
33760146-6	2021	Phorbol-12-myristate-13-acetate (PMA) was used to induce MEG-01 cells maturation and differentiate into platelets following PHB2 knockdown.	Tetradecanoylphorbol Acetate	0-31	prohibitin 2	Homo sapiens	124-128
33760146-6	2021	Phorbol-12-myristate-13-acetate (PMA) was used to induce MEG-01 cells maturation and differentiate into platelets following PHB2 knockdown.	Tetradecanoylphorbol Acetate	33-36	prohibitin 2	Homo sapiens	124-128
33991465-2	2021	PAI-1-targeted fibrinolytic therapy (PAI-1-TFT) is designed to decrease the therapeutic dose of tPA and uPA, attenuating the risk of bleeding and other complications.	Tetradecanoylphorbol Acetate	96-99	serpin family E member 1	Homo sapiens	0-5
33991465-2	2021	PAI-1-targeted fibrinolytic therapy (PAI-1-TFT) is designed to decrease the therapeutic dose of tPA and uPA, attenuating the risk of bleeding and other complications.	Tetradecanoylphorbol Acetate	96-99	serpin family E member 1	Homo sapiens	37-42
33991465-6	2021	PAI-1-TFT with DSP (2.0 mg/kg) converted ineffective doses of single chain (sc) tPA (72.5 microg/kg) and scuPA (62.5 microg/kg) into effective ones in chemically induced pleural injury.	Tetradecanoylphorbol Acetate	80-83	serpin family E member 1	Homo sapiens	0-5
33847415-6	2021	Subjecting these mice to DMBA/TPA mediated skin carcinogenesis revealed that Keratin8 phosphorylation may lead to an early onset of tumors compared to Keratin8 wild-type expressing mice.	Tetradecanoylphorbol Acetate	30-33	keratin 8	Mus musculus	77-85
33724081-11	2022	INTERPRETATION: Our single-center analysis and meta-analysis suggest that tPA can be safely administered based on NCCT with comparable rates of sICH for select WUS/UNK stroke patients.	Tetradecanoylphorbol Acetate	74-77	DnaJ heat shock protein family (Hsp40) member C22	Homo sapiens	160-163
33724081-11	2022	INTERPRETATION: Our single-center analysis and meta-analysis suggest that tPA can be safely administered based on NCCT with comparable rates of sICH for select WUS/UNK stroke patients.	Tetradecanoylphorbol Acetate	74-77	unk zinc finger	Homo sapiens	164-167
33168245-2	2021	The TPA impregnated on KCC-1 (ITPA-KCC-1) was also prepared for comparative.	Tetradecanoylphorbol Acetate	4-7	solute carrier family 12 member 4	Homo sapiens	23-28
33168245-2	2021	The TPA impregnated on KCC-1 (ITPA-KCC-1) was also prepared for comparative.	Tetradecanoylphorbol Acetate	4-7	solute carrier family 12 member 4	Homo sapiens	30-40
33514282-4	2021	Exposure of phorbol-12-myristate-13-acetate (PMA)-differentiated THP1 macrophages to the secretome of CSF conditioned ADSCs downregulated both pro-inflammatory (COX-2, TNFalpha) and anti-inflammatory (SOCS3, IL1RA, TGFbeta) genes in these cells.	Tetradecanoylphorbol Acetate	12-43	interleukin 1 receptor antagonist	Homo sapiens	208-213
33514282-4	2021	Exposure of phorbol-12-myristate-13-acetate (PMA)-differentiated THP1 macrophages to the secretome of CSF conditioned ADSCs downregulated both pro-inflammatory (COX-2, TNFalpha) and anti-inflammatory (SOCS3, IL1RA, TGFbeta) genes in these cells.	Tetradecanoylphorbol Acetate	45-48	interleukin 1 receptor antagonist	Homo sapiens	208-213
32986985-5	2020	Phorbol myristate acetate, triggered a rapid association with early endosomes (Rab5), slow recycling to the plasma membrane (Rab11), and some receptor degradation (Rab7).	Tetradecanoylphorbol Acetate	0-25	RAB5A, member RAS oncogene family	Homo sapiens	79-83
33173997-12	2020	Phorbol 12-myristate 13-acetate, an NF-kappaB pathway activator, reversed the inhibitory effect of C1q on inflammation, macrophage infiltration and mesangial cell (MC) proliferation in renal tissues of LN mice.	Tetradecanoylphorbol Acetate	0-31	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	99-102
32677743-5	2020	In addition, MEMA inhibited the phorbol myristate acetate-stimulated secretion of plasminogen activator inhibitor-1 from cancer cells, leading to the decreased chemotaxis of macrophages.	Tetradecanoylphorbol Acetate	32-57	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	82-115
33381031-0	2020	Suppression of Urokinase-Type Plasminogen Activator Receptor by Docosahexaenoic Acid Mediated by Heme Oxygenase-1 in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Human Endothelial Cells.	Tetradecanoylphorbol Acetate	117-153	plasminogen activator, urokinase receptor	Homo sapiens	15-60
33381031-0	2020	Suppression of Urokinase-Type Plasminogen Activator Receptor by Docosahexaenoic Acid Mediated by Heme Oxygenase-1 in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Human Endothelial Cells.	Tetradecanoylphorbol Acetate	117-153	heme oxygenase 1	Homo sapiens	97-113
33381031-4	2020	The aim of this study was to investigate the effect of DHA on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced uPAR expression and potential role of heme oxygenase-1 (HO-1) in DHA-induced inhibition of uPAR in human endothelial ECV304 cells.	Tetradecanoylphorbol Acetate	62-98	plasminogen activator, urokinase receptor	Homo sapiens	113-117
33381031-4	2020	The aim of this study was to investigate the effect of DHA on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced uPAR expression and potential role of heme oxygenase-1 (HO-1) in DHA-induced inhibition of uPAR in human endothelial ECV304 cells.	Tetradecanoylphorbol Acetate	100-103	plasminogen activator, urokinase receptor	Homo sapiens	113-117
33381031-4	2020	The aim of this study was to investigate the effect of DHA on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced uPAR expression and potential role of heme oxygenase-1 (HO-1) in DHA-induced inhibition of uPAR in human endothelial ECV304 cells.	Tetradecanoylphorbol Acetate	100-103	plasminogen activator, urokinase receptor	Homo sapiens	204-208
33381031-5	2020	Results showed that TPA induced uPAR expression in a time dependent manner, while DHA inhibited uPAR expression in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	20-23	plasminogen activator, urokinase receptor	Homo sapiens	32-36
33381031-7	2020	In addition, DHA-induced inhibition of uPAR expression and cell invasion in TPA-stimulated cells was reversed by si-HO-1 RNA.	Tetradecanoylphorbol Acetate	76-79	plasminogen activator, urokinase receptor	Homo sapiens	39-43
33381031-7	2020	In addition, DHA-induced inhibition of uPAR expression and cell invasion in TPA-stimulated cells was reversed by si-HO-1 RNA.	Tetradecanoylphorbol Acetate	76-79	heme oxygenase 1	Homo sapiens	116-120
32602900-7	2020	In cell line models, PD-L1 expression was found to be significantly enhanced in phorbol-12-myristate 13-acetate activated THP-1 human monocytes (macrophages) treated with LPS or incubated in conditioned media (CM) generated by non-small cell lung cancer (NSCLC) cells.	Tetradecanoylphorbol Acetate	80-111	CD274 molecule	Homo sapiens	21-26
33098048-6	2020	Cells differentiated with RA/TPA or RA differentiated showed increased production of the alpha-synuclein (SNCA) neuroprotein and dopamine neurotransmitter compared to undifferentiated cells, regardless serum concentrations used.	Tetradecanoylphorbol Acetate	29-32	synuclein alpha	Homo sapiens	89-104
33098048-6	2020	Cells differentiated with RA/TPA or RA differentiated showed increased production of the alpha-synuclein (SNCA) neuroprotein and dopamine neurotransmitter compared to undifferentiated cells, regardless serum concentrations used.	Tetradecanoylphorbol Acetate	29-32	synuclein alpha	Homo sapiens	106-110
32673666-4	2020	Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages, followed by induction to osteoclasts using macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL).	Tetradecanoylphorbol Acetate	0-31	colony stimulating factor 1	Homo sapiens	147-183
32673666-4	2020	Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages, followed by induction to osteoclasts using macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL).	Tetradecanoylphorbol Acetate	0-31	colony stimulating factor 1	Homo sapiens	185-190
32720950-1	2020	We report a two-photon responsive drug delivery system (DDS), namely, p-hydroxyphenacyl-naphthalene-chlorambucil (pHP-Naph-Cbl), having a two-photon absorption (TPA) cross-section of >=20 GM in the phototherapeutic window (700 nm).	Tetradecanoylphorbol Acetate	161-164	Cbl proto-oncogene	Homo sapiens	123-126
32753566-3	2020	Diclofenac suppressed the production and gene expression of MUC5AC mucins, induced by PMA through the inhibition of degradation of inhibitory kappa Balpha (IkBalpha) and NF-kB p65 nuclear translocation.	Tetradecanoylphorbol Acetate	86-89	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	60-66
32736685-6	2020	After DMBA/TPA treatment, Prx I deficiency was significantly associated with less skin tumors, lower Bcl-2 expression, and higher p-p38 and cleaved caspase-3 expressions in Prx I knockout tumors than in wild-type controls.	Tetradecanoylphorbol Acetate	11-14	peroxiredoxin 1	Homo sapiens	26-31
32736685-9	2020	In conclusion, the deletion of Prx I triggered the DMBA/TPA-induced skin tumor formation in vivo and in vitro by regulating the reactive oxygen species (ROS)-p38 mitogen-activated protein kinase (MAPK) pathway.	Tetradecanoylphorbol Acetate	56-59	periaxin	Homo sapiens	31-34
31217526-10	2020	In vitro experiments also showed that neutrophils expressed a GnRH receptor and that GnRH agonist treatment increased NETosis markers and promoted phorbol myristate acetate (PMA)-induced NETosis in mouse and human neutrophils.	Tetradecanoylphorbol Acetate	147-172	gonadotropin releasing hormone 1	Mus musculus	85-89
31217526-10	2020	In vitro experiments also showed that neutrophils expressed a GnRH receptor and that GnRH agonist treatment increased NETosis markers and promoted phorbol myristate acetate (PMA)-induced NETosis in mouse and human neutrophils.	Tetradecanoylphorbol Acetate	174-177	gonadotropin releasing hormone 1	Mus musculus	85-89
32780686-10	2020	Conclusions: E2F1 worked as a TF of SPHK1 and exhibited anti-inflammatory and antioxidative effects through SPHK1 in PMA-induced HaCaT cells after 625 nm PBM.	Tetradecanoylphorbol Acetate	117-120	E2F transcription factor 1	Homo sapiens	13-17
32780686-10	2020	Conclusions: E2F1 worked as a TF of SPHK1 and exhibited anti-inflammatory and antioxidative effects through SPHK1 in PMA-induced HaCaT cells after 625 nm PBM.	Tetradecanoylphorbol Acetate	117-120	sphingosine kinase 1	Homo sapiens	108-113
32339486-9	2020	The PKA inhibitor H-89 (10 muM), and the MEK1/2 inhibitor U0126 (10 muM), also produced a significant reduction in the TPA response (~50%).	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase kinase 1	Homo sapiens	41-47
32339486-12	2020	In conclusion, RAIG1/RAI3/GPRC5A corresponds to the originally reported PEIG-1/TIG1; the inhibition observed in the presence of Go 6983, BAPTA and U0126, suggests that its TPA-induced upregulation is mediated through a PKC/Ca2+  MEK1/2 signalling axis.	Tetradecanoylphorbol Acetate	172-175	mitogen-activated protein kinase kinase 1	Homo sapiens	229-235
32715213-3	2020	In the case of derivatives, such a transition is separated by energy, and two TPA peaks can be clearly observed (derivatives containing NO2 and NMe2 groups have two TPA peaks), where the magnitude of the separation is directly related to the intensity of the peripheral group.	Tetradecanoylphorbol Acetate	78-81	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	144-148
32715213-3	2020	In the case of derivatives, such a transition is separated by energy, and two TPA peaks can be clearly observed (derivatives containing NO2 and NMe2 groups have two TPA peaks), where the magnitude of the separation is directly related to the intensity of the peripheral group.	Tetradecanoylphorbol Acetate	165-168	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	144-148
32719792-2	2020	Here we have employed Cap Analysis of Gene Expression (CAGE) to analyze a dense time course of transcriptional regulation in THP-1 cells treated with phorbol myristate acetate (PMA) over 96 h. PMA treatment greatly reduced the numbers of cells entering S phase and also blocked cells exiting G2/M.	Tetradecanoylphorbol Acetate	150-175	DEAD-box helicase 53	Homo sapiens	55-59
32719792-2	2020	Here we have employed Cap Analysis of Gene Expression (CAGE) to analyze a dense time course of transcriptional regulation in THP-1 cells treated with phorbol myristate acetate (PMA) over 96 h. PMA treatment greatly reduced the numbers of cells entering S phase and also blocked cells exiting G2/M.	Tetradecanoylphorbol Acetate	177-180	DEAD-box helicase 53	Homo sapiens	55-59
32719792-2	2020	Here we have employed Cap Analysis of Gene Expression (CAGE) to analyze a dense time course of transcriptional regulation in THP-1 cells treated with phorbol myristate acetate (PMA) over 96 h. PMA treatment greatly reduced the numbers of cells entering S phase and also blocked cells exiting G2/M.	Tetradecanoylphorbol Acetate	193-196	DEAD-box helicase 53	Homo sapiens	55-59
32447451-5	2020	RESULTS: Stimulation of cells by PMA or LPS (without Actovegin ) significantly increased the secretion of IL-1beta, IL-6, IL-10 and TNF-alpha from PBMCs, compared to controls.	Tetradecanoylphorbol Acetate	33-36	interleukin 1 alpha	Homo sapiens	106-114
32447451-9	2020	CONCLUSIONS: Actovegin  can reduce the PMA-induced IL-1beta release and the ROS production from PBMCs.	Tetradecanoylphorbol Acetate	39-42	interleukin 1 alpha	Homo sapiens	51-59
32224540-0	2020	Activity of Dipeptidyl Peptidase-IV/CD26 and Aminopeptidase N/CD13 in Secretome of Mesenchymal Stem Cells after Treatment with LPS and PMA.	Tetradecanoylphorbol Acetate	135-138	dipeptidylpeptidase 4	Mus musculus	12-35
32224540-0	2020	Activity of Dipeptidyl Peptidase-IV/CD26 and Aminopeptidase N/CD13 in Secretome of Mesenchymal Stem Cells after Treatment with LPS and PMA.	Tetradecanoylphorbol Acetate	135-138	alanyl (membrane) aminopeptidase	Mus musculus	45-61
32224540-0	2020	Activity of Dipeptidyl Peptidase-IV/CD26 and Aminopeptidase N/CD13 in Secretome of Mesenchymal Stem Cells after Treatment with LPS and PMA.	Tetradecanoylphorbol Acetate	135-138	alanyl (membrane) aminopeptidase	Mus musculus	62-66
31964467-3	2020	Therefore, we wanted to know whether transduced PEP-1-GLRX1 protein inhibits lipopolysaccharide (LPS)- and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced inflammation.	Tetradecanoylphorbol Acetate	107-144	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	48-53
31964467-3	2020	Therefore, we wanted to know whether transduced PEP-1-GLRX1 protein inhibits lipopolysaccharide (LPS)- and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced inflammation.	Tetradecanoylphorbol Acetate	146-149	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	48-53
31964467-5	2020	In a TPA-induced mouse-ear edema model, topically applied PEP-1-GLRX1 transduced into ear tissues and significantly ameliorated ear edema.	Tetradecanoylphorbol Acetate	5-8	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	58-63
31385383-6	2020	Cytokine production of IFN-gamma and TNF-alpha on CD3- CD56+ NK cells in septic patients was also impaired after stimulation by PMA and ionomycin.	Tetradecanoylphorbol Acetate	128-131	neural cell adhesion molecule 1	Homo sapiens	55-59
31719610-4	2019	Here, we show that the ATP channel pannexin1 (Panx1) is functionally expressed by bone marrow-derived neutrophils (BMDNs) of wild-type (WT) mice and that ATP contributes to NETosis induced in vitro by the calcium ionophore A23187 or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	233-264	pannexin 1	Mus musculus	35-44
31719610-4	2019	Here, we show that the ATP channel pannexin1 (Panx1) is functionally expressed by bone marrow-derived neutrophils (BMDNs) of wild-type (WT) mice and that ATP contributes to NETosis induced in vitro by the calcium ionophore A23187 or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	233-264	pannexin 1	Mus musculus	46-51
31719610-4	2019	Here, we show that the ATP channel pannexin1 (Panx1) is functionally expressed by bone marrow-derived neutrophils (BMDNs) of wild-type (WT) mice and that ATP contributes to NETosis induced in vitro by the calcium ionophore A23187 or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	266-269	pannexin 1	Mus musculus	35-44
31719610-4	2019	Here, we show that the ATP channel pannexin1 (Panx1) is functionally expressed by bone marrow-derived neutrophils (BMDNs) of wild-type (WT) mice and that ATP contributes to NETosis induced in vitro by the calcium ionophore A23187 or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	266-269	pannexin 1	Mus musculus	46-51
31580518-10	2019	After a single TPA application, inflammation of the epidermis was enhanced during LRIG2 overexpression.	Tetradecanoylphorbol Acetate	15-18	leucine-rich repeats and immunoglobulin-like domains 2	Mus musculus	82-87
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	175-206	CD38 molecule	Homo sapiens	23-27
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	175-206	CD38 molecule	Homo sapiens	253-257
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	175-206	CD38 molecule	Homo sapiens	253-257
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	208-211	CD38 molecule	Homo sapiens	23-27
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	208-211	CD38 molecule	Homo sapiens	253-257
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	208-211	CD38 molecule	Homo sapiens	253-257
31206174-5	2019	Further investigation demonstrated that A20 reduces interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha production in CD56bright NK cells after stimulation with monokines or phorbol myristate acetate (PMA)/ionomycin(P/I).	Tetradecanoylphorbol Acetate	184-209	neural cell adhesion molecule 1	Homo sapiens	128-132
31362059-7	2019	Additionally, IL-9Rhigh CD8+ T cells following anti-TCR and PMA + ionomycin stimulation presented higher IL-2 and IL-17 expression, and lower IFN-gamma expression, than IL-9Rlow CD8+ T cells.	Tetradecanoylphorbol Acetate	60-63	interleukin-17A	Sus scrofa	114-119
32648650-6	2019	Results indicate beta-catenin translocalization and activation of TCF/LEF responsive transcription in response to MNP and magnetic fields, which result in dopaminergic marker expression when synergistically combined with differentiation factors retinoic acid and the phorbol ester phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	281-312	catenin beta 1	Homo sapiens	17-29
30959343-1	2019	We designed and synthesized a tri-(2-picolyl) amine (TPA) functionalized triarylborane, 1-(6-(4-(dimesitylboryl)phenyl)pyridin-2-yl)-N,N-bis(pyridin-2-ylmethyl)methanamine (PB2).	Tetradecanoylphorbol Acetate	53-56	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	30-33
30922783-3	2019	Hence, the objective of our study was to evaluate the effect of exogenously administered PAI-1 on uPA/tPA-mediated activation of plasminogen/plasmin and its impact on the progression of arthritis.	Tetradecanoylphorbol Acetate	102-105	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	89-94
30922783-3	2019	Hence, the objective of our study was to evaluate the effect of exogenously administered PAI-1 on uPA/tPA-mediated activation of plasminogen/plasmin and its impact on the progression of arthritis.	Tetradecanoylphorbol Acetate	102-105	plasminogen activator, urokinase	Mus musculus	98-101
30922783-6	2019	PAI-1 administration resulted into decrement in uPA and tPA activities with a concomitant reduction in plasmin and MMP-2.	Tetradecanoylphorbol Acetate	56-59	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	0-5
30444039-6	2019	The inhibition of CerK reduced the phorbol 12-myristate 13-acetate-induced translocation of SphK1 to the plasma membrane (PM) and activation of the enzyme in membrane fractions of cells.	Tetradecanoylphorbol Acetate	35-66	sphingosine kinase 1	Homo sapiens	92-97
30444039-9	2019	The mutation of four cationic amino acids to Ala in the 56-RRNHAR-61 domain in SphK1 reduced the phorbol 12-myristate 13-acetate- and C1P-induced translocation of SphK1 to the PM, however, the capacity of C1P to bind with and activate SphK1 was not affected by this mutation.	Tetradecanoylphorbol Acetate	97-128	sphingosine kinase 1	Homo sapiens	79-84
30771312-9	2019	According to western blotting results, the level of p-ERK was reduced by propofol during PMA-induced NET formation.	Tetradecanoylphorbol Acetate	89-92	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	52-57
30871060-7	2019	GA exhibited a strong inhibitory effect on IRS1ser307 phosphorylation in cells treated with the Protein kinase C (PKC) activator Phorbol 12-myristate 13-acetate (PMA.)	Tetradecanoylphorbol Acetate	129-160	insulin receptor substrate 1	Homo sapiens	43-47
30871060-7	2019	GA exhibited a strong inhibitory effect on IRS1ser307 phosphorylation in cells treated with the Protein kinase C (PKC) activator Phorbol 12-myristate 13-acetate (PMA.)	Tetradecanoylphorbol Acetate	162-165	insulin receptor substrate 1	Homo sapiens	43-47
30701573-14	2019	Our results showed that anti-beta2GPI/beta2GPI triggered NETosis, resembling PMA-induced NETosis in magnitude as well as morphology.	Tetradecanoylphorbol Acetate	77-80	apolipoprotein H	Homo sapiens	29-37
30733557-6	2019	Crystallographic analysis reveals that this specificity is achieved through direct binding of MEDI-579 Fab to the reactive centre loop (RCL) of PAI-1 and at the same exosite used by both tissue and urokinase plasminogen activators (tPA and uPA).	Tetradecanoylphorbol Acetate	232-235	FA complementation group B	Homo sapiens	103-106
30733557-6	2019	Crystallographic analysis reveals that this specificity is achieved through direct binding of MEDI-579 Fab to the reactive centre loop (RCL) of PAI-1 and at the same exosite used by both tissue and urokinase plasminogen activators (tPA and uPA).	Tetradecanoylphorbol Acetate	232-235	serpin family E member 1	Homo sapiens	144-149
30733557-7	2019	We propose that MEDI-579 acts by directly competing with proteases for RCL binding and as such is able to modulate the interaction of PAI-1 with tPA and uPA in a way not previously described for a human PAI-1 inhibitor.	Tetradecanoylphorbol Acetate	145-148	serpin family E member 1	Homo sapiens	134-139
30733557-7	2019	We propose that MEDI-579 acts by directly competing with proteases for RCL binding and as such is able to modulate the interaction of PAI-1 with tPA and uPA in a way not previously described for a human PAI-1 inhibitor.	Tetradecanoylphorbol Acetate	145-148	serpin family E member 1	Homo sapiens	203-208
30721636-9	2019	Both Con A and PMA + Ion-induced secretion of IL-2, IFN-gamma, and TNF-alpha were attenuated by PHI.	Tetradecanoylphorbol Acetate	15-18	interleukin 2	Mus musculus	46-50
30448346-5	2019	The expression of ACTL6A was gradually decreased during granulocytic differentiation in all-trans retinoic acid-treated NB4 and HL-60 cells, and phorbol myristate acetate-treated HL-60 cells.	Tetradecanoylphorbol Acetate	145-170	actin like 6A	Homo sapiens	18-24
30323026-5	2019	Suppression of IL-8 in human embryonic kidney (HEK293) cells that were transformed to express TLR5 was observed not only upon inflammatory stimulation by flagellin but also in response to tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), despite the fact that the TNF-alpha- and PMA-induced inflammatory pathways reportedly are not TLR5 mediated.	Tetradecanoylphorbol Acetate	232-257	toll like receptor 5	Homo sapiens	94-98
30323026-5	2019	Suppression of IL-8 in human embryonic kidney (HEK293) cells that were transformed to express TLR5 was observed not only upon inflammatory stimulation by flagellin but also in response to tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), despite the fact that the TNF-alpha- and PMA-induced inflammatory pathways reportedly are not TLR5 mediated.	Tetradecanoylphorbol Acetate	259-262	toll like receptor 5	Homo sapiens	94-98
30323026-5	2019	Suppression of IL-8 in human embryonic kidney (HEK293) cells that were transformed to express TLR5 was observed not only upon inflammatory stimulation by flagellin but also in response to tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), despite the fact that the TNF-alpha- and PMA-induced inflammatory pathways reportedly are not TLR5 mediated.	Tetradecanoylphorbol Acetate	306-309	toll like receptor 5	Homo sapiens	94-98
29682887-9	2018	Finally, exposure to eluants from nickel-based commercial alloys caused enhanced IL1beta secretion from PMA-treated cells.	Tetradecanoylphorbol Acetate	104-107	interleukin 1 alpha	Homo sapiens	81-88
30197757-6	2018	IL-11 expression under various conditions, including hypoxia or treatment with phorbol 12-myristate 13-acetate or copper sulfate.	Tetradecanoylphorbol Acetate	79-110	interleukin 11	Homo sapiens	0-5
30288224-5	2018	Mechanistic investigations demonstrated that GA down-regulated the expressions of IkappaBalpha and p65 and blocked the phosphorylation of IkappaBalpha and p65 in TPA-induced mouse skin.	Tetradecanoylphorbol Acetate	162-165	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	155-158
30288224-6	2018	Moreover, GA significantly inhibited the TPA-mediated activation of extracellular signal-regulated kinase (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K)/Akt, which are upstream of nuclear factor-kB (NF-kappaB).	Tetradecanoylphorbol Acetate	41-44	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	165-194
30815315-4	2019	Compounds 5, 7, and 9 significantly increased IL-2 secretion in phorbol 12-myristate 13-acetate (PMA)/ionomycin (Io)-induced EL-4 T cells.	Tetradecanoylphorbol Acetate	64-95	interleukin 2	Mus musculus	46-50
30815315-4	2019	Compounds 5, 7, and 9 significantly increased IL-2 secretion in phorbol 12-myristate 13-acetate (PMA)/ionomycin (Io)-induced EL-4 T cells.	Tetradecanoylphorbol Acetate	97-100	interleukin 2	Mus musculus	46-50
29309788-4	2018	The cell motile activity of TPA treated cells was significantly higher than that of PDBu treated cells, correlating with LPAR5 expression levels.	Tetradecanoylphorbol Acetate	28-31	lysophosphatidic acid receptor 5	Homo sapiens	121-126
29309788-5	2018	LPA5 knockdown suppressed the high cell motile activity induced by TPA.	Tetradecanoylphorbol Acetate	67-70	lysophosphatidic acid receptor 5	Homo sapiens	0-4
29433394-8	2018	The W-EA fraction significantly increased IL-2 secretion in EL-4 T cells activated with phorbol 12-myristate 13-acetate (PMA) and ionomycin (Io).	Tetradecanoylphorbol Acetate	88-119	interleukin 2	Mus musculus	42-46
29433394-8	2018	The W-EA fraction significantly increased IL-2 secretion in EL-4 T cells activated with phorbol 12-myristate 13-acetate (PMA) and ionomycin (Io).	Tetradecanoylphorbol Acetate	121-124	interleukin 2	Mus musculus	42-46
30135637-2	2018	One of the important members of the proteolytic family is the plasminogen activation system (PAS), which includes several elements crucial for this review: the 50 kDa glycoprotein plasminogen activator inhibitor 1 (PAI-1) that inhibits tissue-type (tPA) and urokinase-type plasminogen activator (uPA).	Tetradecanoylphorbol Acetate	249-252	serpin family E member 1	Homo sapiens	215-220
28484266-4	2017	Upon phorbol-myristate acetate or Vitamin D3/granulocyte macrophage colony-stimulating factor (GM-CSF)-driven differentiation, both ADAR1 and ADAR2 enzymes are upregulated, with a concomitant global increase of A-to-I RNA editing.	Tetradecanoylphorbol Acetate	5-30	adenosine deaminase RNA specific	Homo sapiens	132-137
29312637-6	2017	Moreover, we are the first to show that Notch regulates by suppressing JunB synthesis and that the negative effect of Notch is partially reversed by treatment with the JunB activator TPA (12-O-tetradeca-noylphorbol-13-acetate).	Tetradecanoylphorbol Acetate	183-186	jun B proto-oncogene	Mus musculus	71-75
29312637-6	2017	Moreover, we are the first to show that Notch regulates by suppressing JunB synthesis and that the negative effect of Notch is partially reversed by treatment with the JunB activator TPA (12-O-tetradeca-noylphorbol-13-acetate).	Tetradecanoylphorbol Acetate	183-186	jun B proto-oncogene	Mus musculus	168-172
29312637-6	2017	Moreover, we are the first to show that Notch regulates by suppressing JunB synthesis and that the negative effect of Notch is partially reversed by treatment with the JunB activator TPA (12-O-tetradeca-noylphorbol-13-acetate).	Tetradecanoylphorbol Acetate	188-225	jun B proto-oncogene	Mus musculus	71-75
29312637-6	2017	Moreover, we are the first to show that Notch regulates by suppressing JunB synthesis and that the negative effect of Notch is partially reversed by treatment with the JunB activator TPA (12-O-tetradeca-noylphorbol-13-acetate).	Tetradecanoylphorbol Acetate	188-225	jun B proto-oncogene	Mus musculus	168-172
28656379-3	2017	Plasminogen is activated by surface receptors, some with renal expression: urokinase-type plasminogen activator receptor (uPAR), plasminogen receptor KT (Plg-RKT), and tPA, most evident in the endothelium.	Tetradecanoylphorbol Acetate	168-171	plasminogen	Rattus norvegicus	0-11
1701344-2	1990	When cells were cultured in the presence of 12-O-tetradecanoylphorbol-13-acetate, significant amounts of IL6 were detected in the culture supernatants of Chang liver cells, HLF cells, and HLE cells.	Tetradecanoylphorbol Acetate	44-80	HLF transcription factor, PAR bZIP family member	Homo sapiens	173-176
2128972-5	1990	Heparin and pentosan polysulfate did not stimulate PAI-1 production by HOMC, while phorbol 12-myristate 13-acetate (100 nM) increased the concentration of PAI-1 in the conditioned medium by 2.6-fold over 24 h. The interaction of heparin with HOMC was studied by direct binding experiments.	Tetradecanoylphorbol Acetate	83-114	serpin family E member 1	Homo sapiens	155-160
30023750-6	2017	Furthermore, the strong two-photon absorption (TPA) with a maximum located at 820 nm along with a TPA cross section sigma2 &gt; 800 GM, and the marked changes in the position and intensity of the band upon complexation definitely make Ant-PIm a promising probe for two-photon excited fluorescence-based discrimination of HSA from BSA.	Tetradecanoylphorbol Acetate	47-50	solute carrier family 25 member 6	Homo sapiens	235-238
30023750-6	2017	Furthermore, the strong two-photon absorption (TPA) with a maximum located at 820 nm along with a TPA cross section sigma2 &gt; 800 GM, and the marked changes in the position and intensity of the band upon complexation definitely make Ant-PIm a promising probe for two-photon excited fluorescence-based discrimination of HSA from BSA.	Tetradecanoylphorbol Acetate	98-101	solute carrier family 25 member 6	Homo sapiens	235-238
2282978-9	1990	The observation that estradiol, TPA and forskolin had effect only on hsp-90 not bound to receptor is an indication that the receptor-hsp-90 complex exists in vivo.	Tetradecanoylphorbol Acetate	32-35	heat shock protein 90 alpha family class A member 1	Homo sapiens	69-75
28837583-6	2017	Analysis of hundreds of individual human peripheral blood NK cells profiled ex vivo revealed that CD56dimCD16+ NK cells are immediate secretors of interferon gamma (IFN-gamma) upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (&lt; 3 h), and that there was no evidence of cooperation between NK cells leading to either synergistic activation or faster IFN-gamma secretion.	Tetradecanoylphorbol Acetate	195-226	neural cell adhesion molecule 1	Homo sapiens	98-109
28837583-6	2017	Analysis of hundreds of individual human peripheral blood NK cells profiled ex vivo revealed that CD56dimCD16+ NK cells are immediate secretors of interferon gamma (IFN-gamma) upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (&lt; 3 h), and that there was no evidence of cooperation between NK cells leading to either synergistic activation or faster IFN-gamma secretion.	Tetradecanoylphorbol Acetate	228-231	neural cell adhesion molecule 1	Homo sapiens	98-109
2282978-9	1990	The observation that estradiol, TPA and forskolin had effect only on hsp-90 not bound to receptor is an indication that the receptor-hsp-90 complex exists in vivo.	Tetradecanoylphorbol Acetate	32-35	heat shock protein 90 alpha family class A member 1	Homo sapiens	133-139
1977513-1	1990	The c-Ha-ras-1 codon 61 A----T transversion is a highly consistent finding in murine skin DMBA-initiated/TPA-promoted papillomas and carcinomas.	Tetradecanoylphorbol Acetate	105-108	POC1 centriolar protein A	Mus musculus	4-8
28785222-7	2017	Plasminogen activator inhibitor-1 (PAI-1) regulates the plasminogen activation system through inhibition of tissue-type and urokinase-type plasminogen activators (tPA and uPA).	Tetradecanoylphorbol Acetate	163-166	serpin family E member 1	Homo sapiens	35-40
1702752-4	1990	Exposure of freshly isolated peripheral blood lymphocytes to phorbol 12-myristate 13-acetate (PMA) and/or calcium ionophores was found to cause rapid down-regulation of the Leu-8 antigen, with little or no Leu-8 reactivity remaining 1 hr after simultaneous addition of PMA and calcium ionophores to the culture medium.	Tetradecanoylphorbol Acetate	61-92	selectin L	Homo sapiens	173-178
28062212-7	2017	Further investigation revealed that either rescue expression of CD147 or treatment of MAPK/ERK activator phorbol 12-myristate 13-acetate (PMA) in CD147 knockdown CRC cell line attenuated the decreased chemoresistance in CD147 knockdown cells.	Tetradecanoylphorbol Acetate	105-136	basigin (Ok blood group)	Homo sapiens	146-151
28062212-7	2017	Further investigation revealed that either rescue expression of CD147 or treatment of MAPK/ERK activator phorbol 12-myristate 13-acetate (PMA) in CD147 knockdown CRC cell line attenuated the decreased chemoresistance in CD147 knockdown cells.	Tetradecanoylphorbol Acetate	105-136	basigin (Ok blood group)	Homo sapiens	146-151
1702752-4	1990	Exposure of freshly isolated peripheral blood lymphocytes to phorbol 12-myristate 13-acetate (PMA) and/or calcium ionophores was found to cause rapid down-regulation of the Leu-8 antigen, with little or no Leu-8 reactivity remaining 1 hr after simultaneous addition of PMA and calcium ionophores to the culture medium.	Tetradecanoylphorbol Acetate	94-97	selectin L	Homo sapiens	173-178
28062212-7	2017	Further investigation revealed that either rescue expression of CD147 or treatment of MAPK/ERK activator phorbol 12-myristate 13-acetate (PMA) in CD147 knockdown CRC cell line attenuated the decreased chemoresistance in CD147 knockdown cells.	Tetradecanoylphorbol Acetate	138-141	basigin (Ok blood group)	Homo sapiens	146-151
1702752-4	1990	Exposure of freshly isolated peripheral blood lymphocytes to phorbol 12-myristate 13-acetate (PMA) and/or calcium ionophores was found to cause rapid down-regulation of the Leu-8 antigen, with little or no Leu-8 reactivity remaining 1 hr after simultaneous addition of PMA and calcium ionophores to the culture medium.	Tetradecanoylphorbol Acetate	94-97	selectin L	Homo sapiens	206-211
28062212-7	2017	Further investigation revealed that either rescue expression of CD147 or treatment of MAPK/ERK activator phorbol 12-myristate 13-acetate (PMA) in CD147 knockdown CRC cell line attenuated the decreased chemoresistance in CD147 knockdown cells.	Tetradecanoylphorbol Acetate	138-141	basigin (Ok blood group)	Homo sapiens	146-151
1702752-9	1990	After Leu-8 down-regulation induced by 1 hr treatment with PMA or calcium ionophores.	Tetradecanoylphorbol Acetate	59-62	selectin L	Homo sapiens	6-11
2233710-2	1990	In this report, we demonstrate that the PEER T-cell line (bearing gamma/delta T-cell receptors) accumulates CSP-B mRNA following exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA) and N6-2"-O-dibutyryladenosine 3",5"-cyclic monophosphate (bt2cAMP) because of transcriptional activation of the CSP-B gene.	Tetradecanoylphorbol Acetate	141-177	granzyme B	Homo sapiens	108-113
27810232-4	2017	OBJECTIVE: To investigate which subsets of IL-17-producing cells are involved in psoriasis-like skin inflammation in a TPA (tumor promoter 12-O-tetradecanoylphorbol-13-acetate)-induced K14.Stat3C mouse model.	Tetradecanoylphorbol Acetate	119-122	keratin 14	Mus musculus	185-188
2233710-2	1990	In this report, we demonstrate that the PEER T-cell line (bearing gamma/delta T-cell receptors) accumulates CSP-B mRNA following exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA) and N6-2"-O-dibutyryladenosine 3",5"-cyclic monophosphate (bt2cAMP) because of transcriptional activation of the CSP-B gene.	Tetradecanoylphorbol Acetate	179-182	granzyme B	Homo sapiens	108-113
27810232-4	2017	OBJECTIVE: To investigate which subsets of IL-17-producing cells are involved in psoriasis-like skin inflammation in a TPA (tumor promoter 12-O-tetradecanoylphorbol-13-acetate)-induced K14.Stat3C mouse model.	Tetradecanoylphorbol Acetate	139-175	keratin 14	Mus musculus	185-188
27810232-5	2017	METHOD: Skin-infiltrating cells were isolated from inflamed lesions of TPA-treated K14.Stat3C transgenic mice, and analyzed for IL-17 producing cell subsets by flow cytometry.	Tetradecanoylphorbol Acetate	71-74	keratin 14	Mus musculus	83-86
2233710-3	1990	TPA and bt2cAMP act synergistically to induce CSP-B expression, since neither agent alone causes activation of CSP-B transcription or mRNA accumulation.	Tetradecanoylphorbol Acetate	0-3	granzyme B	Homo sapiens	46-51
27810232-6	2017	RESULTS: We observed significantly increased numbers of IL-17-producing CD4+ T cells, CD8+ T cells and dermal gammadelta T cells in TPA-induced skin lesions of K14.Stat3C mice.	Tetradecanoylphorbol Acetate	132-135	keratin 14	Mus musculus	160-163
2233710-3	1990	TPA and bt2cAMP act synergistically to induce CSP-B expression, since neither agent alone causes activation of CSP-B transcription or mRNA accumulation.	Tetradecanoylphorbol Acetate	0-3	granzyme B	Homo sapiens	111-116
27810232-11	2017	CONCLUSION: In TPA-induced lesional skin of K14.Stat3C mice, IL-17-producing CD4+ Th17 cells, CD8+ Tc17 cells, dermal gammadelta T cells and TCR- cells probably containing ILCs all participated in skin inflammation, which is similar to human clinical psoriatic features.	Tetradecanoylphorbol Acetate	15-18	keratin 14	Mus musculus	44-47
2233710-4	1990	Chromatin upstream from the CSP-B gene is resistant to DNase I digestion in untreated PEER cells, but becomes sensitive following TPA-bt2cAMP treatment.	Tetradecanoylphorbol Acetate	130-133	granzyme B	Homo sapiens	28-33
2173584-3	1990	In cells stimulated with either TRH or TPA after choline, pHi increased 0.15 +/- 0.05 and 0.14 +/- 0.03 pH units, respectively (mean +/- SD).	Tetradecanoylphorbol Acetate	39-42	glucose-6-phosphate isomerase	Rattus norvegicus	58-61
27327144-12	2017	Exposure to PMA/ionomycin following dextramer exposure resulted in a homogeneous NFAT activation in both the dextramer-positive but NFAT1 nonresponsive CAST and non-CAST cells.	Tetradecanoylphorbol Acetate	12-15	nuclear factor of activated T cells 2	Homo sapiens	132-137
25658763-5	2015	RESULTS: 1) It was mainly the highly-glycosylated form of EMMPRIN (HG-EMMPRIN) that increased after being exposed to inflammatory signals (PMA and H2O2).	Tetradecanoylphorbol Acetate	139-142	basigin (Ok blood group)	Homo sapiens	58-65
27327144-12	2017	Exposure to PMA/ionomycin following dextramer exposure resulted in a homogeneous NFAT activation in both the dextramer-positive but NFAT1 nonresponsive CAST and non-CAST cells.	Tetradecanoylphorbol Acetate	12-15	calpastatin	Homo sapiens	152-156
25658763-5	2015	RESULTS: 1) It was mainly the highly-glycosylated form of EMMPRIN (HG-EMMPRIN) that increased after being exposed to inflammatory signals (PMA and H2O2).	Tetradecanoylphorbol Acetate	139-142	basigin (Ok blood group)	Homo sapiens	70-77
2211693-7	1990	By contrast, PMA only induces a approximately 4-fold increase in GLUT4 while GLUT1 increases approximately 5-fold to the same level as seen with insulin.	Tetradecanoylphorbol Acetate	13-16	solute carrier family 2 member 4	Rattus norvegicus	65-70
27327144-12	2017	Exposure to PMA/ionomycin following dextramer exposure resulted in a homogeneous NFAT activation in both the dextramer-positive but NFAT1 nonresponsive CAST and non-CAST cells.	Tetradecanoylphorbol Acetate	12-15	calpastatin	Homo sapiens	165-169
27910925-5	2016	First, we found that TM was increased when THP-1 cells were treated with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	73-104	thrombomodulin	Homo sapiens	21-23
27910925-5	2016	First, we found that TM was increased when THP-1 cells were treated with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	106-109	thrombomodulin	Homo sapiens	21-23
27910925-7	2016	TM siRNA depressed the PMA-induced increase of p21Cip1/WAF1 via ERK1/2-NF-kB p65 signaling.	Tetradecanoylphorbol Acetate	23-26	thrombomodulin	Homo sapiens	0-2
25613284-9	2015	The granulocyte-macrophage colony-stimulating factor (CSF2) was by far the most over-expressed gene at both T4 and T24 by comparison to mock-stimulated cells, confirming a major impact of PMA-Ionomycin on cell growth and proliferation.	Tetradecanoylphorbol Acetate	188-191	colony stimulating factor 2	Homo sapiens	4-52
1698561-4	1990	CD5 upregulation on TPA-sensitive JM cells appears correlated with inhibition of cell growth, blockage in G1 phase, and phenotypic maturation (downregulation of CD7 and CD1 antigens) and seemed to be related to PKC activation since DiC8 (a PKC activator) mimicked this TPA effect and H7 (a PKC inhibitor) partially reduced it.	Tetradecanoylphorbol Acetate	269-272	CD5 molecule	Homo sapiens	0-3
25613284-9	2015	The granulocyte-macrophage colony-stimulating factor (CSF2) was by far the most over-expressed gene at both T4 and T24 by comparison to mock-stimulated cells, confirming a major impact of PMA-Ionomycin on cell growth and proliferation.	Tetradecanoylphorbol Acetate	188-191	colony stimulating factor 2	Homo sapiens	54-58
27779658-5	2016	In this study, we found that EBGF significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 and -13 and uPA expression via suppression of PMA-induced nuclear translocation of NF-kappaBp65.	Tetradecanoylphorbol Acetate	58-89	proline-rich acidic protein 1	Mus musculus	122-125
27779658-5	2016	In this study, we found that EBGF significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 and -13 and uPA expression via suppression of PMA-induced nuclear translocation of NF-kappaBp65.	Tetradecanoylphorbol Acetate	91-94	proline-rich acidic protein 1	Mus musculus	122-125
1704321-2	1990	In this study the effect of the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA), on the hormonal induction of tyrosinase was examined.	Tetradecanoylphorbol Acetate	48-84	tyrosinase	Mus musculus	121-131
1704321-2	1990	In this study the effect of the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA), on the hormonal induction of tyrosinase was examined.	Tetradecanoylphorbol Acetate	86-89	tyrosinase	Mus musculus	121-131
27708396-7	2016	Knockdown of Tet1 attenuates TPA-induced Zta demethylation and EBV reactivation.	Tetradecanoylphorbol Acetate	29-32	tet methylcytosine dioxygenase 1	Homo sapiens	13-17
25330109-6	2015	An additional H3-derived bait containing the nonhydrolyzable phospho-serine mimic phosphonomethylen-alanine (Pma) at S10 recruited several isoforms of the 14-3-3 family and blocked the recruitment of HAT1 and RBBP7 to the unmodified H3-tail.	Tetradecanoylphorbol Acetate	109-112	RB binding protein 7, chromatin remodeling factor	Homo sapiens	209-214
1704321-3	1990	TPA was found to lower basal levels of tyrosinase activity in melanoma cells and to reduce tyrosinase levels in cells treated with either MSH (10(-7) M), dibutyryl cAMP (10(-4) M), isobutylmethylxanthine (IBMX, 10(-4) M), or with the potent MSH analogue, [Nle4,D-phe7]-alpha-MSH.	Tetradecanoylphorbol Acetate	0-3	tyrosinase	Mus musculus	39-49
25559824-11	2015	Finally, PMA + ionomycin stimulation did not induce significant alterations on MSCs phenotype but did increase indoleamine-2,3-dioxygenase (IDO), inducible costimulatory ligand (ICOSL), IL-1beta, IL-8, and TNF-alpha mRNA expression.	Tetradecanoylphorbol Acetate	9-12	indoleamine 2,3-dioxygenase 1	Homo sapiens	140-143
27708396-8	2016	Thus, TPA activates ERK/c-Jun signaling, which subsequently facilitates Tet1 to bind to Zta promoter, leading to DNA demethylation, gene expression, and EBV reactivation.	Tetradecanoylphorbol Acetate	6-9	tet methylcytosine dioxygenase 1	Homo sapiens	72-76
27520485-7	2016	At the molecular level, the expression of several key TPA-induced pro-survival and pro-proliferative genes (Bcl2, Cyclin D1, and c-Myc) decreased rapidly after BET inhibition.	Tetradecanoylphorbol Acetate	54-57	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	129-134
1704321-3	1990	TPA was found to lower basal levels of tyrosinase activity in melanoma cells and to reduce tyrosinase levels in cells treated with either MSH (10(-7) M), dibutyryl cAMP (10(-4) M), isobutylmethylxanthine (IBMX, 10(-4) M), or with the potent MSH analogue, [Nle4,D-phe7]-alpha-MSH.	Tetradecanoylphorbol Acetate	0-3	tyrosinase	Mus musculus	91-101
1704321-5	1990	In order to determine how TPA may reduce tyrosinase activity in melanoma cells, the levels of tyrosinase mRNA in untreated or TPA-treated cells were determined by Northern blot analysis.	Tetradecanoylphorbol Acetate	26-29	tyrosinase	Mus musculus	41-51
1704321-5	1990	In order to determine how TPA may reduce tyrosinase activity in melanoma cells, the levels of tyrosinase mRNA in untreated or TPA-treated cells were determined by Northern blot analysis.	Tetradecanoylphorbol Acetate	126-129	tyrosinase	Mus musculus	94-104
25883959-1	2015	PAI-1 prevents lysis of blood clot by inhibiting the urokinase and tPA induced conversion of plasminogen to plasmin.	Tetradecanoylphorbol Acetate	67-70	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	0-5
1704321-7	1990	Tyrosinase mRNA levels in cultures exposed to TPA for 48 h were only 7% of control levels.	Tetradecanoylphorbol Acetate	46-49	tyrosinase	Mus musculus	0-10
1704321-8	1990	Tyrosinase mRNA levels in cells treated with both MSH and TPA were also lower than in cells treated with MSH alone.	Tetradecanoylphorbol Acetate	58-61	tyrosinase	Mus musculus	0-10
25883959-10	2015	We have observed a statistically significant (P &lt;= 0.05) reduction of bleeding in PAI-1-treated group in comparison to saline and tPA-treated groups.	Tetradecanoylphorbol Acetate	133-136	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	85-90
2117552-2	1990	The results indicate that the c-Ha-rasva112 protein stimulates the enhancer/promoters of the c-fos gene, the metallothionein IIA gene, the simian virus 40 (SV40) virus genome and the Rous sarcoma (RS) virus genome, and the serum-response element and the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element in a manner independent of protein kinases A and C in NIH/3T3 cells.	Tetradecanoylphorbol Acetate	254-290	POC1 centriolar protein A	Mus musculus	30-34
25490397-8	2014	In addition, phorbol-12-myristate-13-acetate (PMA) decreased ckbeta promoter activity through Ets and GATA elements.	Tetradecanoylphorbol Acetate	13-44	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	102-106
25490397-8	2014	In addition, phorbol-12-myristate-13-acetate (PMA) decreased ckbeta promoter activity through Ets and GATA elements.	Tetradecanoylphorbol Acetate	46-49	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	102-106
27373413-5	2016	Here we show that glycodelin-transfected HEC-1B cells have repressed protein kinase C delta (PKCdelta) activation, likely due to downregulation of PDK1, and are resistant to phenotypic change and enhanced migration induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	226-257	progestagen associated endometrial protein	Homo sapiens	18-28
27373413-5	2016	Here we show that glycodelin-transfected HEC-1B cells have repressed protein kinase C delta (PKCdelta) activation, likely due to downregulation of PDK1, and are resistant to phenotypic change and enhanced migration induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	259-262	progestagen associated endometrial protein	Homo sapiens	18-28
25490397-11	2014	The PMA-mediated repressive effect was abolished by chronic PMA treatment and by treatment with the PKC inhibitor PKC412, but not the PKC inhibitor Go 6983, suggesting PKCepsilon or PKCeta as the PKC isozyme involved in the PMA-mediated repression of ckbeta promoter.	Tetradecanoylphorbol Acetate	4-7	protein kinase C epsilon	Homo sapiens	100-103
27197780-2	2016	Plasminogen activator inhibitor-1 (PAI-1) inhibits urokinase-type and tissue-type plasminogen activator (uPA and tPA) and is the major negative regulator of fibrinolysis.	Tetradecanoylphorbol Acetate	113-116	serpin family E member 1	Homo sapiens	0-33
2117552-2	1990	The results indicate that the c-Ha-rasva112 protein stimulates the enhancer/promoters of the c-fos gene, the metallothionein IIA gene, the simian virus 40 (SV40) virus genome and the Rous sarcoma (RS) virus genome, and the serum-response element and the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element in a manner independent of protein kinases A and C in NIH/3T3 cells.	Tetradecanoylphorbol Acetate	292-295	POC1 centriolar protein A	Mus musculus	30-34
27197780-2	2016	Plasminogen activator inhibitor-1 (PAI-1) inhibits urokinase-type and tissue-type plasminogen activator (uPA and tPA) and is the major negative regulator of fibrinolysis.	Tetradecanoylphorbol Acetate	113-116	serpin family E member 1	Homo sapiens	35-40
25490397-11	2014	The PMA-mediated repressive effect was abolished by chronic PMA treatment and by treatment with the PKC inhibitor PKC412, but not the PKC inhibitor Go 6983, suggesting PKCepsilon or PKCeta as the PKC isozyme involved in the PMA-mediated repression of ckbeta promoter.	Tetradecanoylphorbol Acetate	4-7	protein kinase C epsilon	Homo sapiens	168-178
25490397-11	2014	The PMA-mediated repressive effect was abolished by chronic PMA treatment and by treatment with the PKC inhibitor PKC412, but not the PKC inhibitor Go 6983, suggesting PKCepsilon or PKCeta as the PKC isozyme involved in the PMA-mediated repression of ckbeta promoter.	Tetradecanoylphorbol Acetate	4-7	protein kinase C epsilon	Homo sapiens	114-117
2167455-2	1990	This gene and the related cellular genes c-jun, jun B and jun D, encode transactivating (or repressing) DNA-binding proteins that form homo- or heterodimeric (Jun-Jun and Jun-Fos) complexes which recognize the AP-1 consensus sequence TGACTCA, a response element that confers sensitivity to the tumour-promoting phorbol ester TPA.	Tetradecanoylphorbol Acetate	325-328	FBJ osteosarcoma oncogene	Mus musculus	175-178
25241246-0	2014	Down-regulation of MAPK/NF-kappaB signaling underlies anti-inflammatory response induced by transduced PEP-1-Prx2 proteins in LPS-induced Raw 264.7 and TPA-induced mouse ear edema model.	Tetradecanoylphorbol Acetate	152-155	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	103-108
25241246-7	2014	Transduced PEP-1-Prx2 suppressed intracellular ROS accumulation and inhibited the activity of MAPKs and NF-kappaB signaling that led to the suppression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) and cytokines in LPS-induced Raw 264.7 cells and TPA-induced mouse ear edema model.	Tetradecanoylphorbol Acetate	269-272	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	11-16
27353073-8	2016	Topical compd3 penetrates the skin and suppresses phorbol myristate acetate-induced IL-13, IL-22, IL-17F, and IL-23 transcription and calcipotriol-induced thymic stromal lymphopoietin expression in mouse skin.	Tetradecanoylphorbol Acetate	50-75	interleukin 22	Mus musculus	91-96
27353073-8	2016	Topical compd3 penetrates the skin and suppresses phorbol myristate acetate-induced IL-13, IL-22, IL-17F, and IL-23 transcription and calcipotriol-induced thymic stromal lymphopoietin expression in mouse skin.	Tetradecanoylphorbol Acetate	50-75	interleukin 17F	Mus musculus	98-104
2116475-6	1990	Organ cultured 14-day-old fetal thymocytes treated with IL-4 during 12 days responded vigorously to IL-2 alone and to IL-4 + PMA + ionomycin.	Tetradecanoylphorbol Acetate	125-128	interleukin 4	Mus musculus	56-60
26956118-4	2016	The phorbol 12-myristate 13-acetate (PMA)-stimulated RA monocyte adherence was significantly inhibited by resveratrol (a SIRT1 activator), and this inhibition by resveratrol was prevented by pretreating cells with sirtinol (a SIRT1 inhibitor).	Tetradecanoylphorbol Acetate	4-35	sirtuin 1	Mus musculus	121-126
25176510-6	2014	Upon phorbol 12-myristate 13-acetate (PMA) stimulation, the mRNA levels of matrix metalloproteinases (MMPs) -9, -13, -14 and urokinase plasminogen activator (uPA) decreased in a dose-dependent manner with ASF treatment.	Tetradecanoylphorbol Acetate	5-36	plasminogen activator, urokinase	Mus musculus	125-156
25176510-6	2014	Upon phorbol 12-myristate 13-acetate (PMA) stimulation, the mRNA levels of matrix metalloproteinases (MMPs) -9, -13, -14 and urokinase plasminogen activator (uPA) decreased in a dose-dependent manner with ASF treatment.	Tetradecanoylphorbol Acetate	5-36	plasminogen activator, urokinase	Mus musculus	158-161
25176510-6	2014	Upon phorbol 12-myristate 13-acetate (PMA) stimulation, the mRNA levels of matrix metalloproteinases (MMPs) -9, -13, -14 and urokinase plasminogen activator (uPA) decreased in a dose-dependent manner with ASF treatment.	Tetradecanoylphorbol Acetate	38-41	plasminogen activator, urokinase	Mus musculus	125-156
25176510-6	2014	Upon phorbol 12-myristate 13-acetate (PMA) stimulation, the mRNA levels of matrix metalloproteinases (MMPs) -9, -13, -14 and urokinase plasminogen activator (uPA) decreased in a dose-dependent manner with ASF treatment.	Tetradecanoylphorbol Acetate	38-41	plasminogen activator, urokinase	Mus musculus	158-161
2116478-2	1990	Treatment of growing PBL with phorbol ester (12-O-tetradecanoylphorbol-13-acetate (TPA)) or calcium ionophore (A23187) for 1 h caused phosphorylation of prosolin with the production of up to four prominent phosphorylated forms differing in degree of phosphorylation and/or two-dimensional electrophoretic mobility (peptides B to E).	Tetradecanoylphorbol Acetate	45-81	stathmin 1	Homo sapiens	153-161
25174454-3	2014	In this study, we demonstrated the ability of ginsenoside Rg1 to suppress phorbol myristate acetate (PMA)-induced invasion and migration in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	74-99	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	58-61
25174454-3	2014	In this study, we demonstrated the ability of ginsenoside Rg1 to suppress phorbol myristate acetate (PMA)-induced invasion and migration in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	101-104	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	58-61
2116478-2	1990	Treatment of growing PBL with phorbol ester (12-O-tetradecanoylphorbol-13-acetate (TPA)) or calcium ionophore (A23187) for 1 h caused phosphorylation of prosolin with the production of up to four prominent phosphorylated forms differing in degree of phosphorylation and/or two-dimensional electrophoretic mobility (peptides B to E).	Tetradecanoylphorbol Acetate	83-86	stathmin 1	Homo sapiens	153-161
26956118-4	2016	The phorbol 12-myristate 13-acetate (PMA)-stimulated RA monocyte adherence was significantly inhibited by resveratrol (a SIRT1 activator), and this inhibition by resveratrol was prevented by pretreating cells with sirtinol (a SIRT1 inhibitor).	Tetradecanoylphorbol Acetate	4-35	sirtuin 1	Mus musculus	226-231
2116478-7	1990	The T cell leukemic cells appear to have intact a TPA-activated mechanism for phosphorylating prosolin peptides B and C, but share an impairment of a specific Ca2(+)-activated mechanism, possibly a Ca2(+)-dependent protein kinase, required for phosphorylation of prosolin phosphopeptides D and E. The degree of rapid down-regulation of DNA synthesis was correlated with degree of phosphorylation of peptide E in PBL and in three of four T cell leukemic cell lines.	Tetradecanoylphorbol Acetate	50-53	stathmin 1	Homo sapiens	94-102
26956118-4	2016	The phorbol 12-myristate 13-acetate (PMA)-stimulated RA monocyte adherence was significantly inhibited by resveratrol (a SIRT1 activator), and this inhibition by resveratrol was prevented by pretreating cells with sirtinol (a SIRT1 inhibitor).	Tetradecanoylphorbol Acetate	37-40	sirtuin 1	Mus musculus	121-126
26956118-4	2016	The phorbol 12-myristate 13-acetate (PMA)-stimulated RA monocyte adherence was significantly inhibited by resveratrol (a SIRT1 activator), and this inhibition by resveratrol was prevented by pretreating cells with sirtinol (a SIRT1 inhibitor).	Tetradecanoylphorbol Acetate	37-40	sirtuin 1	Mus musculus	226-231
2116478-8	1990	Thus, rapid phosphorylation of prosolin may mediate responses to TPA and A23187 in normal proliferating PBL, including down-regulation of DNA synthesis.	Tetradecanoylphorbol Acetate	65-68	stathmin 1	Homo sapiens	31-39
26956118-7	2016	Furthermore, SIRT1 activation by resveratrol suppressed PMA-induced phosphorylation and the nuclear translocation of PU.1 and, thus, inhibited monocyte differentiation.	Tetradecanoylphorbol Acetate	56-59	sirtuin 1	Mus musculus	13-18
25256221-3	2014	NDRG2 overexpression in MDA-MB-231 cells inhibited the expression of the COX-2 mRNA and protein, the transcriptional activity of COX-2, and prostaglandin E2 (PGE2) production, which were induced by a treatment with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	215-246	NDRG family member 2	Homo sapiens	0-5
25256221-3	2014	NDRG2 overexpression in MDA-MB-231 cells inhibited the expression of the COX-2 mRNA and protein, the transcriptional activity of COX-2, and prostaglandin E2 (PGE2) production, which were induced by a treatment with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	248-251	NDRG family member 2	Homo sapiens	0-5
2166043-3	1990	In the presence of phorbol myristate acetate (PMA), an activator of PKC and analog of diacylglycerol, IGF-II receptor number increased in the plasma membrane by 60% without changes in the binding affinity.	Tetradecanoylphorbol Acetate	19-44	insulin like growth factor 2 receptor	Homo sapiens	102-117
25256221-7	2014	Consistent with these results, the migration and invasion of MCF7 cells treated with NDRG2 siRNA were significantly enhanced following treatment with PMA.	Tetradecanoylphorbol Acetate	150-153	NDRG family member 2	Homo sapiens	85-90
25245289-2	2014	Previously, we have reported that epithin/PRSS14 undergoes ectodomain shedding in response to phorbol myristate acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	94-119	ST14 transmembrane serine protease matriptase	Homo sapiens	42-48
27486403-11	2016	Cell based experiments reveal that rabbit Nox5 was robustly expressed and produced superoxide at rest and in a calcium and PMA-dependent manner that was susceptible to superoxide dismutase and the flavoprotein inhibitor, DPI.	Tetradecanoylphorbol Acetate	123-126	NADPH oxidase 5	Oryctolagus cuniculus	42-46
2166043-3	1990	In the presence of phorbol myristate acetate (PMA), an activator of PKC and analog of diacylglycerol, IGF-II receptor number increased in the plasma membrane by 60% without changes in the binding affinity.	Tetradecanoylphorbol Acetate	46-49	insulin like growth factor 2 receptor	Homo sapiens	102-117
25245289-2	2014	Previously, we have reported that epithin/PRSS14 undergoes ectodomain shedding in response to phorbol myristate acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	121-124	ST14 transmembrane serine protease matriptase	Homo sapiens	42-48
2118480-3	1990	Pretreatment of murine bone marrow-derived macrophages (BMM) with 10 U/ml murine IL-4 for 48 hr was found to enhance the respiratory burst following subsequent stimulation with phorbol myristate acetate (PMA) (10(-6) M) or zymosan (1 mg/ml).	Tetradecanoylphorbol Acetate	177-202	interleukin 4	Mus musculus	81-85
2118480-3	1990	Pretreatment of murine bone marrow-derived macrophages (BMM) with 10 U/ml murine IL-4 for 48 hr was found to enhance the respiratory burst following subsequent stimulation with phorbol myristate acetate (PMA) (10(-6) M) or zymosan (1 mg/ml).	Tetradecanoylphorbol Acetate	204-207	interleukin 4	Mus musculus	81-85
24804610-7	2014	TPA increased both by increasing baseline SBP and by a 5-year SBP change when adjusted for sex, baseline age, TC, HDL-C, CIMT and current smoking (P for trend &lt;0.001 and 0.004).	Tetradecanoylphorbol Acetate	0-3	CIMT	Homo sapiens	121-125
27128549-7	2016	PCSK9 levels were also linearly associated with TPA after multivariate adjustment including LDL-C (P=0.008).	Tetradecanoylphorbol Acetate	48-51	proprotein convertase subtilisin/kexin type 9	Homo sapiens	0-5
27128549-8	2016	Among participants with the lowest or second tertile of LDL-C, PCSK9 quartiles were linearly associated with TPA (P=0.021), but the association lost significance after additional adjustment for very low-density lipoprotein cholesterol (VLDL-C) tertiles (P=0.072).	Tetradecanoylphorbol Acetate	109-112	proprotein convertase subtilisin/kexin type 9	Homo sapiens	63-68
2199463-6	1990	EGF and 12-0-tetradecanoyl phorbol-13-acetate (TPA) inhibited the Tg mRNA accumulation induced by TSH (and/or insulin).	Tetradecanoylphorbol Acetate	47-50	thyroglobulin	Canis lupus familiaris	66-68
25027711-6	2014	TPA-induced phosphorylation of Akt, S6 kinase (S6K), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) in mouse skin was lower in the curcumin group than in the control group.	Tetradecanoylphorbol Acetate	0-3	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	98-118
25027711-6	2014	TPA-induced phosphorylation of Akt, S6 kinase (S6K), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) in mouse skin was lower in the curcumin group than in the control group.	Tetradecanoylphorbol Acetate	0-3	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	120-125
25178676-5	2014	We demonstrated that IL-32alpha interacts with protein kinase C (PKC)delta and PKCe in a phorbol 12-myristate 13-acetate (PMA) dependent way, and that PKCe regulates the interaction of IL-32alpha with PLZF.	Tetradecanoylphorbol Acetate	89-120	interleukin 32	Homo sapiens	21-31
25178676-5	2014	We demonstrated that IL-32alpha interacts with protein kinase C (PKC)delta and PKCe in a phorbol 12-myristate 13-acetate (PMA) dependent way, and that PKCe regulates the interaction of IL-32alpha with PLZF.	Tetradecanoylphorbol Acetate	89-120	protein kinase C epsilon	Homo sapiens	79-83
2194392-7	1990	When stimulated in vitro by anti-mu and TPA, (phorbol ester) tumor cells showed a decrease in CD21 and Slg and a stronger expression of CD25, T9, T10, and PCA1, with evidence of Ig secretion in four out of the seven cases studied.	Tetradecanoylphorbol Acetate	40-43	sialic acid binding Ig like lectin 12	Homo sapiens	103-106
25178676-5	2014	We demonstrated that IL-32alpha interacts with protein kinase C (PKC)delta and PKCe in a phorbol 12-myristate 13-acetate (PMA) dependent way, and that PKCe regulates the interaction of IL-32alpha with PLZF.	Tetradecanoylphorbol Acetate	122-125	interleukin 32	Homo sapiens	21-31
25178676-5	2014	We demonstrated that IL-32alpha interacts with protein kinase C (PKC)delta and PKCe in a phorbol 12-myristate 13-acetate (PMA) dependent way, and that PKCe regulates the interaction of IL-32alpha with PLZF.	Tetradecanoylphorbol Acetate	122-125	protein kinase C epsilon	Homo sapiens	79-83
25178676-5	2014	We demonstrated that IL-32alpha interacts with protein kinase C (PKC)delta and PKCe in a phorbol 12-myristate 13-acetate (PMA) dependent way, and that PKCe regulates the interaction of IL-32alpha with PLZF.	Tetradecanoylphorbol Acetate	122-125	protein kinase C epsilon	Homo sapiens	151-155
25178676-5	2014	We demonstrated that IL-32alpha interacts with protein kinase C (PKC)delta and PKCe in a phorbol 12-myristate 13-acetate (PMA) dependent way, and that PKCe regulates the interaction of IL-32alpha with PLZF.	Tetradecanoylphorbol Acetate	122-125	interleukin 32	Homo sapiens	185-195
27401543-4	2016	RESULTS: TPA led to localized skin inflammation with increased epidermal thickness, infiltration of inflammatory-like cells and augmented tissue interleukin-17F levels.	Tetradecanoylphorbol Acetate	9-12	interleukin 17F	Mus musculus	145-160
27348266-10	2016	Deletion of Ric-8A in GNAQ(Q209L) cells restored TPA-dependent growth, reduced Galphaq-Q209L below detectable levels and completely mitigated tumorigenesis from primary or secondary cell line grafts.	Tetradecanoylphorbol Acetate	49-52	RIC8 guanine nucleotide exchange factor A	Mus musculus	12-18
2278884-4	1990	Both p120 mRNA and c-myc mRNA levels were significantly decreased in 12-O-tetradecanoyl-phorbol-13-acetate-differentiated HL-60 leukemic cells and in confluent normal immortalized human fibroblasts (WSI).	Tetradecanoylphorbol Acetate	69-106	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	19-24
27163640-0	2016	Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells.	Tetradecanoylphorbol Acetate	74-110	free fatty acid receptor 1	Homo sapiens	32-37
27163640-4	2016	In the present study, we investigated whether GRP120 and GPR40 are involved in regulation of cell motile activity induced by TPA in two melanoma cell lines.	Tetradecanoylphorbol Acetate	125-128	free fatty acid receptor 1	Homo sapiens	57-62
25245533-3	2014	In this study, we showed that PMA induces an interaction between IL-32alpha, PKCepsilon, and BCL6, forming a trimer.	Tetradecanoylphorbol Acetate	30-33	interleukin 32	Homo sapiens	65-75
25245533-3	2014	In this study, we showed that PMA induces an interaction between IL-32alpha, PKCepsilon, and BCL6, forming a trimer.	Tetradecanoylphorbol Acetate	30-33	protein kinase C epsilon	Homo sapiens	77-87
25245533-7	2014	Further, the pan-PKC inhibitor and PKCepsilon inhibitor disrupted PMA-induced interaction between IL-32alpha and BCL6.	Tetradecanoylphorbol Acetate	66-69	protein kinase C epsilon	Homo sapiens	17-45
27163640-5	2016	A375 and G361 cells were treated with TPA at a concentration of 10 nM for 24 h. The cell motile activity of A375 cells was significantly increased by TPA, correlating with GPR40 expression.	Tetradecanoylphorbol Acetate	38-41	free fatty acid receptor 1	Homo sapiens	172-177
25245533-7	2014	Further, the pan-PKC inhibitor and PKCepsilon inhibitor disrupted PMA-induced interaction between IL-32alpha and BCL6.	Tetradecanoylphorbol Acetate	66-69	interleukin 32	Homo sapiens	98-108
1695727-3	1990	Database searches have revealed no similarities between cMG1 and other genes, except that over a 67-amino acid region the cMG1 protein shows 72% identity to the product of the TIS11 gene, a TPA-induced sequence in Swiss 3T3 cells.	Tetradecanoylphorbol Acetate	190-193	zinc finger protein 36, C3H type-like 1	Mus musculus	122-126
25245533-10	2014	PKCepsilon inhibition eliminated PMA-induced SUMOylation of BCL6.	Tetradecanoylphorbol Acetate	33-36	protein kinase C epsilon	Homo sapiens	0-10
27163640-5	2016	A375 and G361 cells were treated with TPA at a concentration of 10 nM for 24 h. The cell motile activity of A375 cells was significantly increased by TPA, correlating with GPR40 expression.	Tetradecanoylphorbol Acetate	150-153	free fatty acid receptor 1	Homo sapiens	172-177
26929603-7	2016	RESULTS: ANDRO ameliorated the increase in the intracellular calcium, protein, and messenger RNA levels of TSLP induced by phorbol myristate acetate/calcium ionophore A23187, through the blocking of the receptor-interacting protein 2/caspase-1/NF-kappaB pathway in human mast cell line 1 cells.	Tetradecanoylphorbol Acetate	123-148	thymic stromal lymphopoietin	Homo sapiens	107-111
2115640-6	1990	Phosphorylation of p78 increased on treatment with TPA and serum as well.	Tetradecanoylphorbol Acetate	51-54	microspherule protein 1	Mus musculus	19-22
26749212-4	2016	The ectopic expression of Eomes induced BW5147 and EL4 cells to produce IFN-gamma in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	97-128	eomesodermin	Mus musculus	26-31
26749212-4	2016	The ectopic expression of Eomes induced BW5147 and EL4 cells to produce IFN-gamma in response to phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	130-133	eomesodermin	Mus musculus	26-31
25059825-2	2014	We previously showed that intestinal expression of the transcriptional coregulator tetradecanoyl phorbol acetate-induced sequence 7 (tis7) is markedly increased during the adaptive response following massive small bowel resection and tis7 plays a role in normal gut lipid metabolism.	Tetradecanoylphorbol Acetate	83-112	interferon-related developmental regulator 1	Mus musculus	133-137
25059825-2	2014	We previously showed that intestinal expression of the transcriptional coregulator tetradecanoyl phorbol acetate-induced sequence 7 (tis7) is markedly increased during the adaptive response following massive small bowel resection and tis7 plays a role in normal gut lipid metabolism.	Tetradecanoylphorbol Acetate	83-112	interferon-related developmental regulator 1	Mus musculus	234-238
24747121-7	2014	Sulforaphane also attenuated TPA-induced activation of IkappaB kinases (IKK), NF-kappaB-activating kinase (NAK) and extracellular signal-regulated kinase-1/2 (ERK1/2).	Tetradecanoylphorbol Acetate	29-32	TANK binding kinase 1	Homo sapiens	78-105
24747121-7	2014	Sulforaphane also attenuated TPA-induced activation of IkappaB kinases (IKK), NF-kappaB-activating kinase (NAK) and extracellular signal-regulated kinase-1/2 (ERK1/2).	Tetradecanoylphorbol Acetate	29-32	TANK binding kinase 1	Homo sapiens	107-110
24747121-9	2014	In addition, the blockade of ERK1/2 activation negated the catalytic activity of IKKalpha, but not that of IKKbeta, whereas silencing NAK by specific siRNA abrogated the IKKbeta activity in TPA-treated cells.	Tetradecanoylphorbol Acetate	190-193	TANK binding kinase 1	Homo sapiens	134-137
2115640-7	1990	Catalase reduced the increase in phosphorylation of p78 induced by TPA and serum.	Tetradecanoylphorbol Acetate	67-70	microspherule protein 1	Mus musculus	52-55
24747121-9	2014	In addition, the blockade of ERK1/2 activation negated the catalytic activity of IKKalpha, but not that of IKKbeta, whereas silencing NAK by specific siRNA abrogated the IKKbeta activity in TPA-treated cells.	Tetradecanoylphorbol Acetate	190-193	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	170-177
2113273-1	1990	The jun and fos gene families encode DNA binding proteins involved in transcriptional regulation of genes containing a TPA responsive element (TRE).	Tetradecanoylphorbol Acetate	119-122	FBJ osteosarcoma oncogene	Mus musculus	12-15
24747121-10	2014	Taken together, sulforaphane inhibits TPA-induced NF-kappaB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKalpha and NAK-IKKbeta.	Tetradecanoylphorbol Acetate	38-41	TANK binding kinase 1	Homo sapiens	185-188
24747121-10	2014	Taken together, sulforaphane inhibits TPA-induced NF-kappaB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKalpha and NAK-IKKbeta.	Tetradecanoylphorbol Acetate	38-41	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	189-196
26619301-4	2016	Here, we report the mechanism of MBCA on phorbol 12-myristate-13-acetate (PMA)- or histamine-induced upregulation of H1R gene expression in HeLa cells, and in vivo effects of MBCA were also determined in toluene-2,4-diisocyanate (TDI)-sensitized rats.	Tetradecanoylphorbol Acetate	41-72	histamine receptor H1	Homo sapiens	117-120
26619301-4	2016	Here, we report the mechanism of MBCA on phorbol 12-myristate-13-acetate (PMA)- or histamine-induced upregulation of H1R gene expression in HeLa cells, and in vivo effects of MBCA were also determined in toluene-2,4-diisocyanate (TDI)-sensitized rats.	Tetradecanoylphorbol Acetate	74-77	histamine receptor H1	Homo sapiens	117-120
2113273-6	1990	In addition, TPA treatment resulted in expression of Fos and Jun protein in RA-differentiated, but not in undifferentiated P19 cells.	Tetradecanoylphorbol Acetate	13-16	FBJ osteosarcoma oncogene	Mus musculus	53-56
24659432-1	2014	A novel nonplanar star-shaped perylene diimide acceptor with a triphenylamine core (S(TPA-PDI)) is explored and applied in solution-processed organic solar cells.	Tetradecanoylphorbol Acetate	86-89	peptidyl arginine deiminase 1	Homo sapiens	90-93
2161627-8	1990	Incubation of both human and guinea pig eosinophils with opsonized zymosan (2 mg/ml) or with phorbol myristate acetate (PMA) (10(-8) and 10(-6) M) resulted in superoxide anion generation and the release of eosinophil peroxidase; albuterol (10(-7) to 10(-5) M) had no inhibitory effect on the release of these products.	Tetradecanoylphorbol Acetate	93-118	eosinophil peroxidase	Cavia porcellus	206-227
24473707-7	2014	Titers of neutralizing antibody against FMDV were significantly higher in mice inoculated with rGTPV-mP1-2A-9m3C, which expresses the 9m3C protease together with mP1-2A, than mice inoculated with the control rGTPV-mP1-2A-TPA, which does not express the protease.	Tetradecanoylphorbol Acetate	221-224	zinc finger protein 185	Mus musculus	101-104
26670291-6	2015	In addition, tPA and uPA were down-regulated due to 42-fold up-regulation of PAI-1.	Tetradecanoylphorbol Acetate	13-16	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	77-82
26391399-6	2015	A pull-down assay revealed that (-)-maackiain disrupted the interaction of Hsp90 with PKCdelta, resulting in the suppression of phorbol 12-myristate 13-acetate (PMA)-induced up-regulation of H1R gene expression in HeLa cells.	Tetradecanoylphorbol Acetate	128-159	histamine receptor H1	Homo sapiens	191-194
2369921-3	1990	We also report that co-treatment with the protein kinase C activator phorbol 12-myristate 13-acetate prevents apoptosis induced by anti-mIg.	Tetradecanoylphorbol Acetate	69-100	chemokine (C-X-C motif) ligand 9	Mus musculus	136-139
26391399-6	2015	A pull-down assay revealed that (-)-maackiain disrupted the interaction of Hsp90 with PKCdelta, resulting in the suppression of phorbol 12-myristate 13-acetate (PMA)-induced up-regulation of H1R gene expression in HeLa cells.	Tetradecanoylphorbol Acetate	161-164	heat shock protein 90 alpha family class A member 1	Homo sapiens	75-80
26391399-6	2015	A pull-down assay revealed that (-)-maackiain disrupted the interaction of Hsp90 with PKCdelta, resulting in the suppression of phorbol 12-myristate 13-acetate (PMA)-induced up-regulation of H1R gene expression in HeLa cells.	Tetradecanoylphorbol Acetate	161-164	histamine receptor H1	Homo sapiens	191-194
26391399-10	2015	The underlying mechanism of the suppression of PMA-induced up-regulation of H1R gene expression by (-)-maackiain and Hsp90 inhibitors is the inhibition of PKCdelta activation through the disruption of Hsp90-PKCdelta interaction.	Tetradecanoylphorbol Acetate	47-50	histamine receptor H1	Homo sapiens	76-79
26391399-10	2015	The underlying mechanism of the suppression of PMA-induced up-regulation of H1R gene expression by (-)-maackiain and Hsp90 inhibitors is the inhibition of PKCdelta activation through the disruption of Hsp90-PKCdelta interaction.	Tetradecanoylphorbol Acetate	47-50	heat shock protein 90 alpha family class A member 1	Homo sapiens	117-122
26391399-10	2015	The underlying mechanism of the suppression of PMA-induced up-regulation of H1R gene expression by (-)-maackiain and Hsp90 inhibitors is the inhibition of PKCdelta activation through the disruption of Hsp90-PKCdelta interaction.	Tetradecanoylphorbol Acetate	47-50	heat shock protein 90 alpha family class A member 1	Homo sapiens	201-206
26319153-5	2015	The treatment of neutrophils with PMA induced phosphorylation of Ser345 on p47(phox), a cytosolic component of NADPH oxidase.	Tetradecanoylphorbol Acetate	34-37	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	79-83
24338918-4	2014	We analyzed the levels of TSLP by treatment with HYP in phorbol myristate acetate plus calcium ionophore A23187-stimulated HMC-1 cells with ELISA and a polymerase chain reaction analysis.	Tetradecanoylphorbol Acetate	56-81	thymic stromal lymphopoietin	Homo sapiens	26-30
2113537-10	1990	Since the biosyntheses of both PGI2 and PAF share a common first step, the hydrolysis of their respective phospholipid precursors by phospholipase A2, we investigated whether PMA preincubation could also enhance PAF biosynthesis.	Tetradecanoylphorbol Acetate	175-178	PCNA clamp associated factor	Homo sapiens	212-215
24503444-6	2014	Mechanistic studies in cell culture revealed that Srx was stimulated by TPA in a redox-independent manner.	Tetradecanoylphorbol Acetate	72-75	sulfiredoxin 1 homolog (S. cerevisiae)	Mus musculus	50-53
2165782-5	1990	Primary mouse osteoblasts also induced the c-fos gene in response to epidermal growth factor, insulin-like growth factor-I and several agents, including phorbol 12-myristate 13-acetate (TPA), forskolin and A23187, that are known to activate signal transduction pathways involved in the action of growth factors.	Tetradecanoylphorbol Acetate	153-184	FBJ osteosarcoma oncogene	Mus musculus	43-48
24503444-9	2014	These findings suggested that loss of Srx protected mice, at least partially, from DMBA/TPA-induced skin tumorigenesis.	Tetradecanoylphorbol Acetate	88-91	sulfiredoxin 1 homolog (S. cerevisiae)	Mus musculus	38-41
26009271-10	2015	Moreover, we found out that PKC activator phorbol 12-myristate 13-acetate (PMA) not only affects the internalization of OATP1B1 but its recycling as well.	Tetradecanoylphorbol Acetate	42-73	solute carrier organic anion transporter family member 1B1	Homo sapiens	120-127
26009271-10	2015	Moreover, we found out that PKC activator phorbol 12-myristate 13-acetate (PMA) not only affects the internalization of OATP1B1 but its recycling as well.	Tetradecanoylphorbol Acetate	75-78	solute carrier organic anion transporter family member 1B1	Homo sapiens	120-127
24697594-15	2014	In all cases, 1:1 adducts [Tpa(x)CuL]PF6 [L = PPh3 (9-11), CO (12-15)] have been isolated.	Tetradecanoylphorbol Acetate	27-30	protein phosphatase 4 catalytic subunit	Homo sapiens	46-50
2165782-5	1990	Primary mouse osteoblasts also induced the c-fos gene in response to epidermal growth factor, insulin-like growth factor-I and several agents, including phorbol 12-myristate 13-acetate (TPA), forskolin and A23187, that are known to activate signal transduction pathways involved in the action of growth factors.	Tetradecanoylphorbol Acetate	186-189	FBJ osteosarcoma oncogene	Mus musculus	43-48
2189400-0	1990	The phorbol ester TPA induces a translocation of the insulin sensitive glucose carrier (GLUT4) in fat cells.	Tetradecanoylphorbol Acetate	18-21	solute carrier family 2 member 4	Rattus norvegicus	88-93
24697594-16	2014	The crystal structure of [Tpa*Cu(PPh3)]PF6 (9) has been obtained, showing that the coordination geometry around copper(I) is trigonal-pyramidal with the apical position occupied by the tertiary amine N atom.	Tetradecanoylphorbol Acetate	26-29	protein phosphatase 4 catalytic subunit	Homo sapiens	33-37
24669362-5	2014	Indeed, the serine proteases urokinase plasminogen activator and tissue-type plasminogen activator (uPA/tPA) and their major phsyiological inhibitor, plasminogen activator inhibitor-1 (PAI-1; serine protease inhibitor clade E member 1 [SERPINE1]), are upregulated in several cell types during injury repair.	Tetradecanoylphorbol Acetate	104-107	serpin family E member 1	Homo sapiens	185-190
26335138-3	2015	RESULTS: The peripheral Th1/Th2 was detected by Ionomycin and phorbol myristate acetate (PMA)-stimulating peripheral blood mononuclear cells (PBMC) of phase pregnant mice.	Tetradecanoylphorbol Acetate	62-87	heart and neural crest derivatives expressed 2	Mus musculus	28-31
26335138-3	2015	RESULTS: The peripheral Th1/Th2 was detected by Ionomycin and phorbol myristate acetate (PMA)-stimulating peripheral blood mononuclear cells (PBMC) of phase pregnant mice.	Tetradecanoylphorbol Acetate	89-92	heart and neural crest derivatives expressed 2	Mus musculus	28-31
24669362-5	2014	Indeed, the serine proteases urokinase plasminogen activator and tissue-type plasminogen activator (uPA/tPA) and their major phsyiological inhibitor, plasminogen activator inhibitor-1 (PAI-1; serine protease inhibitor clade E member 1 [SERPINE1]), are upregulated in several cell types during injury repair.	Tetradecanoylphorbol Acetate	104-107	serpin family E member 1	Homo sapiens	192-234
2189400-4	1990	We found that the phorbol ester TPA is able to increase the amount of GLUT4 in the plasma membrane fraction about two-fold.	Tetradecanoylphorbol Acetate	32-35	solute carrier family 2 member 4	Rattus norvegicus	70-75
24669362-5	2014	Indeed, the serine proteases urokinase plasminogen activator and tissue-type plasminogen activator (uPA/tPA) and their major phsyiological inhibitor, plasminogen activator inhibitor-1 (PAI-1; serine protease inhibitor clade E member 1 [SERPINE1]), are upregulated in several cell types during injury repair.	Tetradecanoylphorbol Acetate	104-107	serpin family E member 1	Homo sapiens	236-244
2110813-2	1990	Tonsil B-cells responded to phorbol ester (TPA) by an increased beta 2m production rate, which was further enhanced by the combined stimuli of TPA plus the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	43-46	beta-2-microglobulin	Homo sapiens	64-71
26117319-6	2015	In monocytes and macrophages, phorbol 12-myristate 13-acetate (PMA) induced NADPH activation and TRX-1/PRX-1 release to the extracellular medium, with a concomitant decrease in their intracellular levels, which was reversed by the NADPH inhibitor apocynin (Western blot).	Tetradecanoylphorbol Acetate	30-61	thioredoxin	Homo sapiens	97-102
26117319-6	2015	In monocytes and macrophages, phorbol 12-myristate 13-acetate (PMA) induced NADPH activation and TRX-1/PRX-1 release to the extracellular medium, with a concomitant decrease in their intracellular levels, which was reversed by the NADPH inhibitor apocynin (Western blot).	Tetradecanoylphorbol Acetate	30-61	peroxiredoxin 1	Homo sapiens	103-108
26117319-6	2015	In monocytes and macrophages, phorbol 12-myristate 13-acetate (PMA) induced NADPH activation and TRX-1/PRX-1 release to the extracellular medium, with a concomitant decrease in their intracellular levels, which was reversed by the NADPH inhibitor apocynin (Western blot).	Tetradecanoylphorbol Acetate	63-66	thioredoxin	Homo sapiens	97-102
26117319-6	2015	In monocytes and macrophages, phorbol 12-myristate 13-acetate (PMA) induced NADPH activation and TRX-1/PRX-1 release to the extracellular medium, with a concomitant decrease in their intracellular levels, which was reversed by the NADPH inhibitor apocynin (Western blot).	Tetradecanoylphorbol Acetate	63-66	peroxiredoxin 1	Homo sapiens	103-108
24161965-7	2014	When GL-1 and UL-1 cells were treated with PMA and the MAPK/ERK kinase inhibitor U0126, ABCG2 gene expression levels were elevated above those in untreated cells.	Tetradecanoylphorbol Acetate	43-46	ATP binding cassette subfamily G member 2	Canis lupus familiaris	88-93
24161965-8	2014	Similarly, ABCG2 gene expression increased above control levels in UL-1 and Ema cells treated with PMA and the JNK inhibitor SP600125.	Tetradecanoylphorbol Acetate	99-102	ATP binding cassette subfamily G member 2	Canis lupus familiaris	11-16
26117319-7	2015	In loss-of-function experiments, genetic silencing of the NADPH oxidase subunit Nox2 blocked PMA-induced intracellular TRX-1/PRX-1 downregulation in macrophages.	Tetradecanoylphorbol Acetate	93-96	thioredoxin	Homo sapiens	119-124
2110813-2	1990	Tonsil B-cells responded to phorbol ester (TPA) by an increased beta 2m production rate, which was further enhanced by the combined stimuli of TPA plus the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	143-146	beta-2-microglobulin	Homo sapiens	64-71
26117319-7	2015	In loss-of-function experiments, genetic silencing of the NADPH oxidase subunit Nox2 blocked PMA-induced intracellular TRX-1/PRX-1 downregulation in macrophages.	Tetradecanoylphorbol Acetate	93-96	peroxiredoxin 1	Homo sapiens	125-130
26117319-8	2015	Furthermore, the PMA-induced release of TRX-1/PRX-1 involves the modulation of their redox status and exosome-like vesicles.	Tetradecanoylphorbol Acetate	17-20	thioredoxin	Homo sapiens	40-45
2110813-3	1990	In marked contrast, however, lymphocytes from a majority (8/11) of B-cell malignancies showed a suppression of the TPA-induced beta 2m production rate in response to the combined TPA/A23187 stimulus.	Tetradecanoylphorbol Acetate	115-118	beta-2-microglobulin	Homo sapiens	127-134
26117319-8	2015	Furthermore, the PMA-induced release of TRX-1/PRX-1 involves the modulation of their redox status and exosome-like vesicles.	Tetradecanoylphorbol Acetate	17-20	peroxiredoxin 1	Homo sapiens	46-51
2110813-3	1990	In marked contrast, however, lymphocytes from a majority (8/11) of B-cell malignancies showed a suppression of the TPA-induced beta 2m production rate in response to the combined TPA/A23187 stimulus.	Tetradecanoylphorbol Acetate	179-182	beta-2-microglobulin	Homo sapiens	127-134
24281857-2	2014	Earlier studies on human colon carcinoma HT-29 cells have shown that treatment with phorbol 12-myristate 13-acetate (PMA) activates NOX thus increasing the intracellular level of ROS and upregulating GGT.	Tetradecanoylphorbol Acetate	84-115	gamma-glutamyltransferase light chain family member 3	Homo sapiens	200-203
2324095-3	1990	Synthesis of PAI-2 and transcription of its mRNA could be induced by a protein kinase C (PKC) activator, phorbol myristate acetate.	Tetradecanoylphorbol Acetate	105-130	serpin family B member 2	Homo sapiens	13-18
24281857-2	2014	Earlier studies on human colon carcinoma HT-29 cells have shown that treatment with phorbol 12-myristate 13-acetate (PMA) activates NOX thus increasing the intracellular level of ROS and upregulating GGT.	Tetradecanoylphorbol Acetate	117-120	gamma-glutamyltransferase light chain family member 3	Homo sapiens	200-203
24281857-6	2014	The combined FCCP and PMA treatment also provoked highly increased GGT mRNA levels after 24 h whereas only minor and delayed increases in GGT protein and enzyme activity levels were detected.	Tetradecanoylphorbol Acetate	22-25	gamma-glutamyltransferase light chain family member 3	Homo sapiens	67-70
23982114-8	2014	ASP(+) uptake by mOCT3 and human OCT3 (hOCT3) was efficiently inhibited by 1-methyl-4-phenylpyridinium, tetrapentylammonium (TPA(+)), corticosterone, serotonin, and histamine and by the drugs ketamine, fluoxetine, and diazepam.	Tetradecanoylphorbol Acetate	125-128	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	17-22
23982114-9	2014	The half maximal inhibitory concentrations of mOCT3 and hOCT3 for TPA(+), serotonin, diazepam, and ketamine are significantly different.	Tetradecanoylphorbol Acetate	66-69	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	46-51
25725291-3	2015	Transfection of short-interfering RNA to PEA-15 (siPEA-15) significantly induced nuclear translocation of SA-pErk1/2, and siPEA-15 with TPA co-treatment further increased the translocation.	Tetradecanoylphorbol Acetate	136-139	proliferation and apoptosis adaptor protein 15	Homo sapiens	41-47
25725291-4	2015	Moreover, the reversal of senescence phenotype, such as expressions of SA-beta-galactosidase, p53, p21(WAF1), PML body, 53BP1 and H3K9me2, was modified by either knockdown of PEA-15 or TPA treatment, indicating that nuclear translocation of SA-pErk1/2 might inhibit senescence progression.	Tetradecanoylphorbol Acetate	185-188	proliferation and apoptosis adaptor protein 15	Homo sapiens	175-181
2324095-6	1990	Staurosporine and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride also inhibited both TNF- and phorbol myristate acetate-induced PAI-2 mRNA accumulation.	Tetradecanoylphorbol Acetate	109-134	serpin family B member 2	Homo sapiens	143-148
2156674-17	1990	Furthermore, Bay K and 12-O-tetradecanoyl-phorbol-13-acetate pretreatment effectively blocked the fast feedback effects of corticosterone on CRH-mediated ACTH release.	Tetradecanoylphorbol Acetate	23-60	corticotropin releasing hormone	Homo sapiens	141-144
25711724-2	2015	Because protein kinase C (PKC) mimetic phorbol myristate acetate (PMA) can destabilize natriuretic peptide clearance receptor (NPR-C) mRNA and angiotensin II activates several PKC isoforms in VSMCs, we hypothesized that angiotensin II treatment decreases NPR-C mRNA stability and exerts this effect through PKC.	Tetradecanoylphorbol Acetate	39-64	natriuretic peptide receptor 3	Rattus norvegicus	87-125
25711724-2	2015	Because protein kinase C (PKC) mimetic phorbol myristate acetate (PMA) can destabilize natriuretic peptide clearance receptor (NPR-C) mRNA and angiotensin II activates several PKC isoforms in VSMCs, we hypothesized that angiotensin II treatment decreases NPR-C mRNA stability and exerts this effect through PKC.	Tetradecanoylphorbol Acetate	39-64	natriuretic peptide receptor 3	Rattus norvegicus	127-132
25711724-2	2015	Because protein kinase C (PKC) mimetic phorbol myristate acetate (PMA) can destabilize natriuretic peptide clearance receptor (NPR-C) mRNA and angiotensin II activates several PKC isoforms in VSMCs, we hypothesized that angiotensin II treatment decreases NPR-C mRNA stability and exerts this effect through PKC.	Tetradecanoylphorbol Acetate	39-64	natriuretic peptide receptor 3	Rattus norvegicus	255-260
25711724-2	2015	Because protein kinase C (PKC) mimetic phorbol myristate acetate (PMA) can destabilize natriuretic peptide clearance receptor (NPR-C) mRNA and angiotensin II activates several PKC isoforms in VSMCs, we hypothesized that angiotensin II treatment decreases NPR-C mRNA stability and exerts this effect through PKC.	Tetradecanoylphorbol Acetate	66-69	natriuretic peptide receptor 3	Rattus norvegicus	87-125
24117055-3	2014	The cytokine milieu containing elevated IL-17, which often appears in active states of autoimmunity, was mimicked in vitro by a supernatant obtained from rat peripheral blood monocytes stimulated with phorbol mystistate acetate (PMA)/ionomycin.	Tetradecanoylphorbol Acetate	229-232	interleukin 17A	Rattus norvegicus	40-45
24465855-5	2014	Furthermore, topically applied PEP-1-PON1 protein ameliorates TPA-treated mice skin inflammation via a reduction of inflammatory response.	Tetradecanoylphorbol Acetate	62-65	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	31-36
25711724-2	2015	Because protein kinase C (PKC) mimetic phorbol myristate acetate (PMA) can destabilize natriuretic peptide clearance receptor (NPR-C) mRNA and angiotensin II activates several PKC isoforms in VSMCs, we hypothesized that angiotensin II treatment decreases NPR-C mRNA stability and exerts this effect through PKC.	Tetradecanoylphorbol Acetate	66-69	natriuretic peptide receptor 3	Rattus norvegicus	127-132
1698209-5	1990	However, the optimal concentration of G-CSF (50 ng/ml) was able to prime human neutrophils with enhance of O2- release stimulated by the chemotactic peptide, N-formyl-methionyl-leucyl-phenylalanine (FMLP) from 10(-6) to 10(-8) M, but not by the non chemoattractant such as phorbol myristate acetate (PMA), concanavalin A, and ionomycin.	Tetradecanoylphorbol Acetate	273-298	colony stimulating factor 3	Homo sapiens	38-43
25711724-2	2015	Because protein kinase C (PKC) mimetic phorbol myristate acetate (PMA) can destabilize natriuretic peptide clearance receptor (NPR-C) mRNA and angiotensin II activates several PKC isoforms in VSMCs, we hypothesized that angiotensin II treatment decreases NPR-C mRNA stability and exerts this effect through PKC.	Tetradecanoylphorbol Acetate	66-69	natriuretic peptide receptor 3	Rattus norvegicus	255-260
25941985-6	2015	We further confirmed that CPT inhibits PMA-induced MMP-9 and VEGF expression by upregulating nuclear factor-erythroid related factor-2 (Nrf2)-mediated heme oxygenase-1 (HO-1) induction.	Tetradecanoylphorbol Acetate	39-42	heme oxygenase 1	Homo sapiens	151-167
24295961-4	2014	We analyzed the effect of TR on the level of TSLP from phorbol myristate acetate/calcium ionophore A23187-activated human mast cell line, HMC-1 cells, in 2,4-dinitrofluorobenzene-induced AD-like skin lesions of NC/Nga mice, and in anti-CD3/anti-CD28-stimulated splenocytes.	Tetradecanoylphorbol Acetate	55-80	thymic stromal lymphopoietin	Homo sapiens	45-49
1698209-5	1990	However, the optimal concentration of G-CSF (50 ng/ml) was able to prime human neutrophils with enhance of O2- release stimulated by the chemotactic peptide, N-formyl-methionyl-leucyl-phenylalanine (FMLP) from 10(-6) to 10(-8) M, but not by the non chemoattractant such as phorbol myristate acetate (PMA), concanavalin A, and ionomycin.	Tetradecanoylphorbol Acetate	300-303	colony stimulating factor 3	Homo sapiens	38-43
25941985-6	2015	We further confirmed that CPT inhibits PMA-induced MMP-9 and VEGF expression by upregulating nuclear factor-erythroid related factor-2 (Nrf2)-mediated heme oxygenase-1 (HO-1) induction.	Tetradecanoylphorbol Acetate	39-42	heme oxygenase 1	Homo sapiens	169-173
24337742-5	2014	ADAM17 was found to be expressed on NK cells, and stimulation with PMA or N-ethyl-maleimide resulted in the shedding of FcgammaRIIIA/CD16A and CD62L, a specific substrate of ADAM17.	Tetradecanoylphorbol Acetate	67-70	selectin L	Homo sapiens	143-148
2138707-1	1990	Proto-oncogene products c-Fos and c-Jun form a complex which binds with high affinity to the 12-O-tetradecanoylphorbol-13-acetate (TPA) response DNA element and which stimulates transcription of phorbol ester- inducible genes.	Tetradecanoylphorbol Acetate	93-129	FBJ osteosarcoma oncogene	Mus musculus	24-29
24249517-4	2015	These findings support a function of OPN in mediating TPA-induced neoplastic transformation of JB6 cells.	Tetradecanoylphorbol Acetate	54-57	secreted phosphoprotein 1	Homo sapiens	37-40
24249517-5	2015	In regard to the mechanism of action by OPN, we hypothesized that, for JB6 cells grown in soft-agar, secreted OPN induced by TPA stimulates cell proliferation and/or prevents anoikis to facilitate TPA-induced colony formation.	Tetradecanoylphorbol Acetate	125-128	secreted phosphoprotein 1	Homo sapiens	40-43
24249517-5	2015	In regard to the mechanism of action by OPN, we hypothesized that, for JB6 cells grown in soft-agar, secreted OPN induced by TPA stimulates cell proliferation and/or prevents anoikis to facilitate TPA-induced colony formation.	Tetradecanoylphorbol Acetate	125-128	secreted phosphoprotein 1	Homo sapiens	110-113
24249517-5	2015	In regard to the mechanism of action by OPN, we hypothesized that, for JB6 cells grown in soft-agar, secreted OPN induced by TPA stimulates cell proliferation and/or prevents anoikis to facilitate TPA-induced colony formation.	Tetradecanoylphorbol Acetate	197-200	secreted phosphoprotein 1	Homo sapiens	110-113
23765132-7	2014	The acute stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced Eng expression in mouse epidermal keratinocytes in vivo and in vitro associated with hyperproliferation.	Tetradecanoylphorbol Acetate	27-63	endoglin	Mus musculus	79-82
23765132-7	2014	The acute stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced Eng expression in mouse epidermal keratinocytes in vivo and in vitro associated with hyperproliferation.	Tetradecanoylphorbol Acetate	65-68	endoglin	Mus musculus	79-82
2105841-7	1990	Thus, c-fos expression in both wild-type and TPAR-3 cells is a consequence of PKC activation, and the development of resistance to TPA-antiproliferative effects in the TPAR-3 cell line was not linked causally to alterations in PKC levels or the c-fos mRNA induction response.	Tetradecanoylphorbol Acetate	45-48	FBJ osteosarcoma oncogene	Mus musculus	6-11
24380573-0	2014	Naturally occurring phenolic acids modulate TPA-induced activation of EGFR, AP-1, and STATs in mouse epidermis.	Tetradecanoylphorbol Acetate	44-47	epidermal growth factor receptor	Mus musculus	70-74
2105854-0	1990	IL-2, IL-6, and IFN-gamma have distinct effects on the IL-4 plus PMA-induced proliferation of thymocyte subpopulations.	Tetradecanoylphorbol Acetate	65-68	interleukin 2	Mus musculus	0-4
2154605-2	1990	We identified several elements within the BZLF1 promoter (Zp) which are responsive to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), an inducer of the viral lytic cycle.	Tetradecanoylphorbol Acetate	142-145	protein Zta	Human gammaherpesvirus 4	42-47
24220687-0	2014	Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression.	Tetradecanoylphorbol Acetate	73-76	heme oxygenase 1	Homo sapiens	117-121
24243709-7	2015	Phorbol 12-myristate 13-acetate (PMA) and ionomycin enhanced activity of NFAT1, reduced E-cadherin and alpha-catenin protein levels, and increased protein levels of N-cadherin and Vimentin.	Tetradecanoylphorbol Acetate	0-31	vimentin	Homo sapiens	180-188
24243709-7	2015	Phorbol 12-myristate 13-acetate (PMA) and ionomycin enhanced activity of NFAT1, reduced E-cadherin and alpha-catenin protein levels, and increased protein levels of N-cadherin and Vimentin.	Tetradecanoylphorbol Acetate	33-36	vimentin	Homo sapiens	180-188
2154606-4	1990	64:1217-1226, 1990), the promoter for the BZLF1 gene (Zp) contains two distinct types of elements (ZI and ZII [an AP-1-like domain]) which are responsive to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), an inducer of the viral lytic cycle.	Tetradecanoylphorbol Acetate	175-211	protein Zta	Human gammaherpesvirus 4	42-47
2154606-4	1990	64:1217-1226, 1990), the promoter for the BZLF1 gene (Zp) contains two distinct types of elements (ZI and ZII [an AP-1-like domain]) which are responsive to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), an inducer of the viral lytic cycle.	Tetradecanoylphorbol Acetate	213-216	protein Zta	Human gammaherpesvirus 4	42-47
23876794-4	2013	In the present study we revealed NuFkappaBeta as the upstream mediator involved in Btg2 transcription in response to cell stress challenges such as serum deprivation and oxidative stress i.e. H2O2, TPA or doxorubicin treatments in several cell lines.	Tetradecanoylphorbol Acetate	198-201	BTG anti-proliferation factor 2	Homo sapiens	83-87
25726525-5	2015	Using previously established cell lines that stably express IL-32theta and IL-32beta and cell lines transiently expressing IL-32theta, we observed that expression of IL-32theta inhibited phorbol 12-myristate 13-acetate (PMA)-induced monocytic differentiation in both THP-1 and HL-60 cells.	Tetradecanoylphorbol Acetate	187-218	interleukin 32	Homo sapiens	75-84
2304467-2	1990	In contrast to the C-kinase-dependent phosphorylation of hsp28 in response to the tumor promoter phorbol-12-myristate-13-acetate, the heat- and tumor necrosis factor-mediated phosphorylation of this heat shock protein appears to occur independently of C kinase.	Tetradecanoylphorbol Acetate	97-128	heat shock protein family B (small) member 1	Homo sapiens	57-62
25726525-5	2015	Using previously established cell lines that stably express IL-32theta and IL-32beta and cell lines transiently expressing IL-32theta, we observed that expression of IL-32theta inhibited phorbol 12-myristate 13-acetate (PMA)-induced monocytic differentiation in both THP-1 and HL-60 cells.	Tetradecanoylphorbol Acetate	187-218	interleukin 32	Homo sapiens	60-65
25079913-3	2015	CCK (0.3, 100 nM) and TPA (1 muM) activated SFK and altered the activation of FAK proteins (PYK2, p125(FAK)), adaptor proteins (p130(CAS), paxillin), MAPK (p42/44, JNK, p38), Shc, PKC (PKD, MARCKS), Akt but not GSK3-beta.	Tetradecanoylphorbol Acetate	22-25	protein tyrosine kinase 2	Rattus norvegicus	78-81
25079913-3	2015	CCK (0.3, 100 nM) and TPA (1 muM) activated SFK and altered the activation of FAK proteins (PYK2, p125(FAK)), adaptor proteins (p130(CAS), paxillin), MAPK (p42/44, JNK, p38), Shc, PKC (PKD, MARCKS), Akt but not GSK3-beta.	Tetradecanoylphorbol Acetate	22-25	protein tyrosine kinase 2	Rattus norvegicus	98-108
25079913-3	2015	CCK (0.3, 100 nM) and TPA (1 muM) activated SFK and altered the activation of FAK proteins (PYK2, p125(FAK)), adaptor proteins (p130(CAS), paxillin), MAPK (p42/44, JNK, p38), Shc, PKC (PKD, MARCKS), Akt but not GSK3-beta.	Tetradecanoylphorbol Acetate	22-25	mitogen-activated protein kinase 8	Rattus norvegicus	164-167
24035999-8	2013	Real-time imaging in MIN6 cells expressing green fluorescent protein-tagged DGKalpha or DGKgamma showed that the DGK activator phorbol 12-myristate 13-acetate rapidly induced translocation of DGKgamma to the plasma membrane, whereas high K(+) slowly translocated DGKalpha and DGKgamma to the plasma membrane.	Tetradecanoylphorbol Acetate	127-158	diacylglycerol kinase, beta	Mus musculus	76-79
2298725-2	1990	Treatment with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) also results in the transmodulation of the EGF receptor in many cell types.	Tetradecanoylphorbol Acetate	35-71	epidermal growth factor	Mus musculus	121-124
23879967-7	2013	Meanwhile upregulating the [Ca2+]i either by TG or phorbol myristate acetate (PMA) could stimulate the production of MMP-9 in A375 cells with the expression of Basigin.	Tetradecanoylphorbol Acetate	51-76	basigin (Ok blood group)	Homo sapiens	160-167
23879967-7	2013	Meanwhile upregulating the [Ca2+]i either by TG or phorbol myristate acetate (PMA) could stimulate the production of MMP-9 in A375 cells with the expression of Basigin.	Tetradecanoylphorbol Acetate	78-81	basigin (Ok blood group)	Homo sapiens	160-167
2298725-2	1990	Treatment with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) also results in the transmodulation of the EGF receptor in many cell types.	Tetradecanoylphorbol Acetate	73-76	epidermal growth factor	Mus musculus	121-124
25587030-7	2014	Without affecting Akt phosphorylation, PMA increased phosphorylation of S6K (T389) and S6 (S240/244), and that was completely prevented by rapamycin.	Tetradecanoylphorbol Acetate	39-42	ribosomal protein S6 kinase B1	Homo sapiens	72-75
25587030-8	2014	Yet, T421/S424 and S235/236 (p-S6K and p-S6, respectively) phosphorylation became rapamycin-insensitive in the presence of PMA.	Tetradecanoylphorbol Acetate	123-126	ribosomal protein S6 kinase B1	Homo sapiens	29-34
2298725-6	1990	264, 213-219) described the requirement for a sodium ion influx in the down-modulation of the EGF receptor stimulated by a non-TPA-type tumor promoter, palytoxin, in Swiss 3T3 cells.	Tetradecanoylphorbol Acetate	127-130	epidermal growth factor	Mus musculus	94-97
23940030-6	2013	In addition, FBXO25 overexpression suppressed induction of two ELK-1 target genes, c-fos and egr-1, in response to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	115-146	early growth response 1	Homo sapiens	93-98
25374129-10	2014	In addition, piceatannol decreased TPA-induced expression of c-Fos and the DNA binding of AP-1.	Tetradecanoylphorbol Acetate	35-38	FBJ osteosarcoma oncogene	Mus musculus	61-66
25374129-11	2014	CONCLUSION: Piceatannol inhibits TPA-induced COX-2 and iNOS expression by blocking the activation of NF-kappaB and AP-1 via suppression of the IKKbeta activity and phosphorylation of MAP kinases, which provides a mechanistic basis of its anti-inflammatory effects in mouse skin.	Tetradecanoylphorbol Acetate	33-36	inhibitor of kappaB kinase beta	Mus musculus	143-150
2298725-8	1990	Our results clearly show that the PDGF- and TPA-stimulated transmodulation of the EGF receptor does not require external sodium nor is the process affected by amiloride.	Tetradecanoylphorbol Acetate	44-47	epidermal growth factor	Mus musculus	82-85
23988002-2	2013	PAI-1 is a fast acting inhibitor of tissue and urokinase plasminogen activators (tPA and uPA).	Tetradecanoylphorbol Acetate	81-84	serpin family E member 1	Homo sapiens	0-5
23988002-3	2013	PAI-1 controls/slows clot lysis triggered by tPA activated plasminogen.	Tetradecanoylphorbol Acetate	45-48	serpin family E member 1	Homo sapiens	0-5
2116958-3	1990	It is thought that this paradoxical phenomenon occurred due to desensitization accompanied by down-regulation of LH-RH receptors induced by TPA.	Tetradecanoylphorbol Acetate	140-143	gonadotropin releasing hormone 1	Rattus norvegicus	113-118
2116958-4	1990	This hypothesis was supported by the finding indicating that the binding capacity of LH-RH receptors decreased in a time-course manner during incubation with TPA.	Tetradecanoylphorbol Acetate	158-161	gonadotropin releasing hormone 1	Rattus norvegicus	85-90
23623171-4	2013	RESULTS: Platelets stimulated with LPS plus PMA for 4 hours expressed trace amounts of TF like activity (PCA), not inhibited by anti-TF antibody (0.2+-0.1 mU/ml blood).	Tetradecanoylphorbol Acetate	44-47	coagulation factor III, tissue factor	Homo sapiens	87-89
2311647-4	1990	IL2 was most successfully induced with a high dose of the calcium ionophore A23187 combined with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	97-128	interleukin 2	Mus musculus	0-3
23429041-6	2013	DHA also remarkably reduced PMA-induced p65, C/EBPbeta, c-jun and CREB nuclear translocation.	Tetradecanoylphorbol Acetate	28-31	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	40-43
23429041-6	2013	DHA also remarkably reduced PMA-induced p65, C/EBPbeta, c-jun and CREB nuclear translocation.	Tetradecanoylphorbol Acetate	28-31	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	45-54
23643258-4	2013	Moreover, IFN-gamma, IL-4, IL-9 and IL-17 secreted by gammadeltaT cells were detected by means of intracellular cytokine staining after stimulation with PMA plus ionomycin.	Tetradecanoylphorbol Acetate	153-156	interleukin 4	Mus musculus	21-25
25123399-4	2014	Optimized DSCs sensitized with IB2 having two TPA groups in combination with tris(2,2"-bipyridyl) cobalt(II/III) yield efficiencies of 6.3%, similar to that of IB3, which is equipped with mutiple alkoxy groups.	Tetradecanoylphorbol Acetate	46-49	mitogen-activated protein kinase 8 interacting protein 2	Homo sapiens	31-34
25123399-6	2014	These results demonstrate that both TPA groups on the IB2 are needed for an efficient blocking effect.	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase 8 interacting protein 2	Homo sapiens	54-57
2311647-4	1990	IL2 was most successfully induced with a high dose of the calcium ionophore A23187 combined with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	130-133	interleukin 2	Mus musculus	0-3
25241044-4	2014	The purpose of our study was to investigate the molecular mechanisms by which curcumin affects MMP-9, MMP13 and EMMPRIN in PMA (phorbol 12-myristate 13-acetate) induced macrophages.	Tetradecanoylphorbol Acetate	128-159	basigin (Ok blood group)	Homo sapiens	112-119
2329998-7	1990	The effects of IL-1 were mimicked by the tumor promoter phorbol 12-myristate 13-acetate (PMA) at 1-100 nM, which inhibited CDP and reduced procollagen alpha 1(I) mRNA levels to a similar extent.	Tetradecanoylphorbol Acetate	56-87	cut-like homeobox 1	Mus musculus	123-126
25241044-8	2014	Furthermore, curcumin reversed PMA stimulated PKC activation and suppressed the chronic activation of AMPK, which in turn reduced the expression of MMP-9, MMP-13 and EMMPRIN.	Tetradecanoylphorbol Acetate	31-34	basigin (Ok blood group)	Homo sapiens	166-173
24054007-2	2013	METHODS: Human colon cancer LoVo cells were divided into three groups: phorbol 12-myristate 13-acetate (PMA) was used to induce the activation of SphK1 in the PMA group, N,N-dimethylsphingosine (DMS) used to suppress the activity of SphK1 in DMS group, and the cells treated with equal amount of 0.9 % NaCl instead of drugs served as the control group.	Tetradecanoylphorbol Acetate	71-102	sphingosine kinase 1	Homo sapiens	146-151
24054007-2	2013	METHODS: Human colon cancer LoVo cells were divided into three groups: phorbol 12-myristate 13-acetate (PMA) was used to induce the activation of SphK1 in the PMA group, N,N-dimethylsphingosine (DMS) used to suppress the activity of SphK1 in DMS group, and the cells treated with equal amount of 0.9 % NaCl instead of drugs served as the control group.	Tetradecanoylphorbol Acetate	71-102	sphingosine kinase 1	Homo sapiens	233-238
24054007-2	2013	METHODS: Human colon cancer LoVo cells were divided into three groups: phorbol 12-myristate 13-acetate (PMA) was used to induce the activation of SphK1 in the PMA group, N,N-dimethylsphingosine (DMS) used to suppress the activity of SphK1 in DMS group, and the cells treated with equal amount of 0.9 % NaCl instead of drugs served as the control group.	Tetradecanoylphorbol Acetate	104-107	sphingosine kinase 1	Homo sapiens	146-151
2329998-7	1990	The effects of IL-1 were mimicked by the tumor promoter phorbol 12-myristate 13-acetate (PMA) at 1-100 nM, which inhibited CDP and reduced procollagen alpha 1(I) mRNA levels to a similar extent.	Tetradecanoylphorbol Acetate	89-92	cut-like homeobox 1	Mus musculus	123-126
2107107-7	1990	Likewise, the stimulation of tPA mRNA levels by dibutyryl cAMP, a protein kinase A activator, and phorbol myristate acetate (PMA), a protein kinase C activator, was enhanced by cotreatment with DEX or R1881.	Tetradecanoylphorbol Acetate	98-123	plasminogen activator, tissue type	Rattus norvegicus	29-32
23589925-8	2013	Pretreatment of C6 cells with phorbol 12-myristate 13-acetate (PMA), a PKC activator, at 0.1 nM to 0.1 microM for 2 to 15 min caused a reduction of histamine-induced IP1 formation and [Ca2+] accumulation, but enhanced histamine-induced AA release and GPI formation.	Tetradecanoylphorbol Acetate	30-61	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	166-169
23589925-8	2013	Pretreatment of C6 cells with phorbol 12-myristate 13-acetate (PMA), a PKC activator, at 0.1 nM to 0.1 microM for 2 to 15 min caused a reduction of histamine-induced IP1 formation and [Ca2+] accumulation, but enhanced histamine-induced AA release and GPI formation.	Tetradecanoylphorbol Acetate	63-66	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	166-169
25003971-6	2014	PMA (10(-8) M), a PKC activator, increased Cu(I)-ATPase activity by 60%, whereas calphostin C and U73122 (PKC and PLC inhibitors, respectively) decreased the activity by 40%.	Tetradecanoylphorbol Acetate	0-3	protein kinase C epsilon	Homo sapiens	18-21
25133483-5	2014	We show that ectopic IkappaB kinase e (IKKe) expression in these cells partly restored MMP-3 expression levels and also sensitized MMP-3 transcription to induction by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	167-198	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	21-37
2107107-7	1990	Likewise, the stimulation of tPA mRNA levels by dibutyryl cAMP, a protein kinase A activator, and phorbol myristate acetate (PMA), a protein kinase C activator, was enhanced by cotreatment with DEX or R1881.	Tetradecanoylphorbol Acetate	125-128	plasminogen activator, tissue type	Rattus norvegicus	29-32
25133483-5	2014	We show that ectopic IkappaB kinase e (IKKe) expression in these cells partly restored MMP-3 expression levels and also sensitized MMP-3 transcription to induction by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	167-198	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	39-43
2295643-5	1990	Using U937 promonocytic cells as a model, we demonstrated; 1) cathepsin G protein levels decline in TPA-treated cells; 2) this decline was due to a nearly complete loss of cathepsin G mRNA in cells treated with TPA for 24 h; and 3) the rate of cathepsin G mRNA loss with TPA treatment was similar to that with actinomycin D.	Tetradecanoylphorbol Acetate	100-103	cathepsin G	Homo sapiens	62-73
24659803-5	2014	We then investigated tescalcin and CSN activity in human erythroleukemia HEL and promyelocytic leukemia K562 cells and find that phorbol 12-myristate 13-acetate (PMA)-induced differentiation, resulting in the upregulation of tescalcin, coincides with reduced deneddylation of cullin-1 (Cul1) and stabilization of p27(Kip1) - molecular events that are associated with CSN activity.	Tetradecanoylphorbol Acetate	129-160	interferon alpha inducible protein 27	Homo sapiens	313-316
24659803-5	2014	We then investigated tescalcin and CSN activity in human erythroleukemia HEL and promyelocytic leukemia K562 cells and find that phorbol 12-myristate 13-acetate (PMA)-induced differentiation, resulting in the upregulation of tescalcin, coincides with reduced deneddylation of cullin-1 (Cul1) and stabilization of p27(Kip1) - molecular events that are associated with CSN activity.	Tetradecanoylphorbol Acetate	129-160	cyclin dependent kinase inhibitor 1B	Homo sapiens	317-321
24659803-5	2014	We then investigated tescalcin and CSN activity in human erythroleukemia HEL and promyelocytic leukemia K562 cells and find that phorbol 12-myristate 13-acetate (PMA)-induced differentiation, resulting in the upregulation of tescalcin, coincides with reduced deneddylation of cullin-1 (Cul1) and stabilization of p27(Kip1) - molecular events that are associated with CSN activity.	Tetradecanoylphorbol Acetate	162-165	interferon alpha inducible protein 27	Homo sapiens	313-316
24659803-5	2014	We then investigated tescalcin and CSN activity in human erythroleukemia HEL and promyelocytic leukemia K562 cells and find that phorbol 12-myristate 13-acetate (PMA)-induced differentiation, resulting in the upregulation of tescalcin, coincides with reduced deneddylation of cullin-1 (Cul1) and stabilization of p27(Kip1) - molecular events that are associated with CSN activity.	Tetradecanoylphorbol Acetate	162-165	cyclin dependent kinase inhibitor 1B	Homo sapiens	317-321
23501100-2	2013	In this study, we revealed that the expression of PU.1 was increased and accompanied by downregulation of MT-1A expression during TPA-induced THP-1 monocyte differentiation.	Tetradecanoylphorbol Acetate	130-133	Spi-1 proto-oncogene	Homo sapiens	50-54
2295643-5	1990	Using U937 promonocytic cells as a model, we demonstrated; 1) cathepsin G protein levels decline in TPA-treated cells; 2) this decline was due to a nearly complete loss of cathepsin G mRNA in cells treated with TPA for 24 h; and 3) the rate of cathepsin G mRNA loss with TPA treatment was similar to that with actinomycin D.	Tetradecanoylphorbol Acetate	100-103	cathepsin G	Homo sapiens	172-183
23401860-6	2013	Using dominant negative mutants and rescue experiments, we demonstrate the functional significance of FLNB K1147 to interfere with the ability of phorbol myristate acetate (PMA) to promote FLNB-mediated cytoplasmic accumulation of HDAC7.	Tetradecanoylphorbol Acetate	146-171	filamin B	Homo sapiens	102-106
23401860-6	2013	Using dominant negative mutants and rescue experiments, we demonstrate the functional significance of FLNB K1147 to interfere with the ability of phorbol myristate acetate (PMA) to promote FLNB-mediated cytoplasmic accumulation of HDAC7.	Tetradecanoylphorbol Acetate	146-171	filamin B	Homo sapiens	189-193
2295643-5	1990	Using U937 promonocytic cells as a model, we demonstrated; 1) cathepsin G protein levels decline in TPA-treated cells; 2) this decline was due to a nearly complete loss of cathepsin G mRNA in cells treated with TPA for 24 h; and 3) the rate of cathepsin G mRNA loss with TPA treatment was similar to that with actinomycin D.	Tetradecanoylphorbol Acetate	100-103	cathepsin G	Homo sapiens	172-183
23401860-6	2013	Using dominant negative mutants and rescue experiments, we demonstrate the functional significance of FLNB K1147 to interfere with the ability of phorbol myristate acetate (PMA) to promote FLNB-mediated cytoplasmic accumulation of HDAC7.	Tetradecanoylphorbol Acetate	146-171	histone deacetylase 7	Homo sapiens	231-236
2295643-5	1990	Using U937 promonocytic cells as a model, we demonstrated; 1) cathepsin G protein levels decline in TPA-treated cells; 2) this decline was due to a nearly complete loss of cathepsin G mRNA in cells treated with TPA for 24 h; and 3) the rate of cathepsin G mRNA loss with TPA treatment was similar to that with actinomycin D.	Tetradecanoylphorbol Acetate	211-214	cathepsin G	Homo sapiens	62-73
23401860-6	2013	Using dominant negative mutants and rescue experiments, we demonstrate the functional significance of FLNB K1147 to interfere with the ability of phorbol myristate acetate (PMA) to promote FLNB-mediated cytoplasmic accumulation of HDAC7.	Tetradecanoylphorbol Acetate	173-176	filamin B	Homo sapiens	102-106
23401860-6	2013	Using dominant negative mutants and rescue experiments, we demonstrate the functional significance of FLNB K1147 to interfere with the ability of phorbol myristate acetate (PMA) to promote FLNB-mediated cytoplasmic accumulation of HDAC7.	Tetradecanoylphorbol Acetate	173-176	filamin B	Homo sapiens	189-193
2295643-5	1990	Using U937 promonocytic cells as a model, we demonstrated; 1) cathepsin G protein levels decline in TPA-treated cells; 2) this decline was due to a nearly complete loss of cathepsin G mRNA in cells treated with TPA for 24 h; and 3) the rate of cathepsin G mRNA loss with TPA treatment was similar to that with actinomycin D.	Tetradecanoylphorbol Acetate	211-214	cathepsin G	Homo sapiens	172-183
23401860-6	2013	Using dominant negative mutants and rescue experiments, we demonstrate the functional significance of FLNB K1147 to interfere with the ability of phorbol myristate acetate (PMA) to promote FLNB-mediated cytoplasmic accumulation of HDAC7.	Tetradecanoylphorbol Acetate	173-176	histone deacetylase 7	Homo sapiens	231-236
23255458-0	2014	PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells.	Tetradecanoylphorbol Acetate	35-38	pyruvate kinase M1/2	Homo sapiens	0-4
2295643-5	1990	Using U937 promonocytic cells as a model, we demonstrated; 1) cathepsin G protein levels decline in TPA-treated cells; 2) this decline was due to a nearly complete loss of cathepsin G mRNA in cells treated with TPA for 24 h; and 3) the rate of cathepsin G mRNA loss with TPA treatment was similar to that with actinomycin D.	Tetradecanoylphorbol Acetate	211-214	cathepsin G	Homo sapiens	172-183
23255458-5	2014	Herein, we used the skin epidermal JB6 P+ cells and demonstrated that shikonin suppressed the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) induced neoplastic cell transformation and PKM2 activation in the early stage of carcinogenesis.	Tetradecanoylphorbol Acetate	147-150	pyruvate kinase M1/2	Homo sapiens	195-199
2295643-5	1990	Using U937 promonocytic cells as a model, we demonstrated; 1) cathepsin G protein levels decline in TPA-treated cells; 2) this decline was due to a nearly complete loss of cathepsin G mRNA in cells treated with TPA for 24 h; and 3) the rate of cathepsin G mRNA loss with TPA treatment was similar to that with actinomycin D.	Tetradecanoylphorbol Acetate	211-214	cathepsin G	Homo sapiens	62-73
2295643-5	1990	Using U937 promonocytic cells as a model, we demonstrated; 1) cathepsin G protein levels decline in TPA-treated cells; 2) this decline was due to a nearly complete loss of cathepsin G mRNA in cells treated with TPA for 24 h; and 3) the rate of cathepsin G mRNA loss with TPA treatment was similar to that with actinomycin D.	Tetradecanoylphorbol Acetate	211-214	cathepsin G	Homo sapiens	172-183
23353996-4	2013	To verify the regulatory mechanism of TPA-induced             MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126,             and TPA-induced MMP-9 expression was significantly decreased.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase kinase 1	Homo sapiens	121-127
2295643-5	1990	Using U937 promonocytic cells as a model, we demonstrated; 1) cathepsin G protein levels decline in TPA-treated cells; 2) this decline was due to a nearly complete loss of cathepsin G mRNA in cells treated with TPA for 24 h; and 3) the rate of cathepsin G mRNA loss with TPA treatment was similar to that with actinomycin D.	Tetradecanoylphorbol Acetate	211-214	cathepsin G	Homo sapiens	172-183
23313748-6	2013	Activation of PKC by 12-O-tetradecanoylphorbol-13-acetate dramatically decreased MCM7 DNA replication licensing and induced cell growth arrest.	Tetradecanoylphorbol Acetate	21-57	minichromosome maintenance complex component 7	Homo sapiens	81-85
24722289-12	2014	Phorbol 12-myristate 13-acetate (PMA), which stimulates PKCs, induced p66(Shc) phosphorylation and this was inhibited by ruboxistaurin and PKCbeta2 siRNA.	Tetradecanoylphorbol Acetate	0-31	DNA polymerase delta 3, accessory subunit	Homo sapiens	70-73
24722289-12	2014	Phorbol 12-myristate 13-acetate (PMA), which stimulates PKCs, induced p66(Shc) phosphorylation and this was inhibited by ruboxistaurin and PKCbeta2 siRNA.	Tetradecanoylphorbol Acetate	33-36	DNA polymerase delta 3, accessory subunit	Homo sapiens	70-73
2295643-6	1990	These results suggested that cathepsin G transcription was down-regulated within several hours of TPA addition.	Tetradecanoylphorbol Acetate	98-101	cathepsin G	Homo sapiens	29-40
2295643-7	1990	This was directly tested by performing nuclear run-off assays of TPA-treated U937 cells; cathepsin G transcription was shown to be strand-specific, and declined within 4 h of TPA addition.	Tetradecanoylphorbol Acetate	65-68	cathepsin G	Homo sapiens	89-100
2295643-7	1990	This was directly tested by performing nuclear run-off assays of TPA-treated U937 cells; cathepsin G transcription was shown to be strand-specific, and declined within 4 h of TPA addition.	Tetradecanoylphorbol Acetate	175-178	cathepsin G	Homo sapiens	89-100
23339930-6	2013	The changes 8 h after TPA treatment probably reflected transcriptional regulation, and the genes were divided into three groups, up-regulated (IL-6, MCP-1, HO-1 and SOCS3), unregulated (IL-1beta, TNF-alpha and IL-10) and down-regulated (RANTES) genes.	Tetradecanoylphorbol Acetate	22-25	suppressor of cytokine signaling 3	Mus musculus	165-170
2295643-8	1990	Cathepsin G transcription was essentially undetectable 8 or more hours after TPA treatment, suggesting that down-regulation is predominantly transcriptional.	Tetradecanoylphorbol Acetate	77-80	cathepsin G	Homo sapiens	0-11
2295643-9	1990	Cycloheximide treatment of U937 cells resulted in a partial block of TPA-mediated cathepsin G down-regulation, indicating that continuous protein synthesis is required for down-regulation to occur.	Tetradecanoylphorbol Acetate	69-72	cathepsin G	Homo sapiens	82-93
2295806-1	1990	12-O-Tetradecanoylphorbol-13-acetate (TPA), a tumor-promoting phorbol ester, induced the proliferation of connective tissue-type mast cells (CTMC) synergistically with IL-3 in a methylcellulose culture, as well as with IL-4.	Tetradecanoylphorbol Acetate	0-36	interleukin 3	Homo sapiens	168-172
23430963-6	2013	In addition, a peptide inhibitor of PKCalpha superinduced ionophore activation of PAD4, thus identifying PKCalpha as the PMA-induced inhibitor of PAD4.	Tetradecanoylphorbol Acetate	121-124	peptidyl arginine deiminase 4	Homo sapiens	82-86
2295806-1	1990	12-O-Tetradecanoylphorbol-13-acetate (TPA), a tumor-promoting phorbol ester, induced the proliferation of connective tissue-type mast cells (CTMC) synergistically with IL-3 in a methylcellulose culture, as well as with IL-4.	Tetradecanoylphorbol Acetate	38-41	interleukin 3	Homo sapiens	168-172
23430963-6	2013	In addition, a peptide inhibitor of PKCalpha superinduced ionophore activation of PAD4, thus identifying PKCalpha as the PMA-induced inhibitor of PAD4.	Tetradecanoylphorbol Acetate	121-124	peptidyl arginine deiminase 4	Homo sapiens	146-150
24322293-10	2014	Furthermore, intracellular cytokine staining revealed that expression of IL-4 and IL-17 were significantly enhanced in both the NK and NKT cells of infected mice after phorbol 12-myristate 13-acetate (PMA) and ionomycin stimulation (P &lt; 0.05).	Tetradecanoylphorbol Acetate	168-199	interleukin 4	Mus musculus	73-77
24322293-10	2014	Furthermore, intracellular cytokine staining revealed that expression of IL-4 and IL-17 were significantly enhanced in both the NK and NKT cells of infected mice after phorbol 12-myristate 13-acetate (PMA) and ionomycin stimulation (P &lt; 0.05).	Tetradecanoylphorbol Acetate	201-204	interleukin 4	Mus musculus	73-77
2295806-3	1990	Although the populations of CTMC acted on by TPA and IL-4 seemed to be close to each other, the velocity of colony growth induced by the simultaneous stimulation of the combination of TPA and IL-4 was faster than that induced by either TPA or IL-4 in the presence of IL-3.	Tetradecanoylphorbol Acetate	184-187	interleukin 3	Homo sapiens	267-271
2149958-9	1990	After activation with the tumor promoter, TPA, the level of ETS2 elevates 5- to 20-fold.	Tetradecanoylphorbol Acetate	42-45	ETS proto-oncogene 2, transcription factor	Homo sapiens	60-64
24523905-8	2014	Silencing of tryptophan hydroxylase-1 or hydroxyindole O-methyltransferase in proliferative fibroblasts with siRNA resulted in elevation of PMA-induced p300 histone acetyltransferase activity to the level of that in quiescent fibroblasts, which was rescued by addition of 5-hydroxytryptophan or 5-methoxytryptophan.	Tetradecanoylphorbol Acetate	140-143	tryptophan hydroxylase 1	Homo sapiens	13-74
23268563-6	2013	Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion.	Tetradecanoylphorbol Acetate	6-37	matrix metallopeptidase 1	Homo sapiens	116-142
23268563-6	2013	Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion.	Tetradecanoylphorbol Acetate	6-37	matrix metallopeptidase 1	Homo sapiens	144-149
23268563-6	2013	Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion.	Tetradecanoylphorbol Acetate	39-42	matrix metallopeptidase 1	Homo sapiens	116-142
23268563-6	2013	Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion.	Tetradecanoylphorbol Acetate	39-42	matrix metallopeptidase 1	Homo sapiens	144-149
24362330-10	2014	In agreement with the above results, PMA dose-dependently reduced intracellular ATP level and stimulated P-gp ATPase activity in both Caco-2 and MDCKII-MDR1 cells.	Tetradecanoylphorbol Acetate	37-40	phosphoglycolate phosphatase	Homo sapiens	105-109
24362330-12	2014	CONCLUSION: PMA significantly inhibited P-gp-mediated efflux of digoxin in both Caco-2 and MDCKII-MDR1 cell monolayers via PKC activation.	Tetradecanoylphorbol Acetate	12-15	phosphoglycolate phosphatase	Homo sapiens	40-44
2331149-3	1990	In addition, UDMH suppressed phorbol myristic acetate (PMA)-stimulated IL-2 production in EL-4 cells by up to 30% and slightly suppressed IL-2 production by Con A-stimulated murine splenocytes.	Tetradecanoylphorbol Acetate	55-58	interleukin 2	Mus musculus	71-75
23107437-0	2013	Withaferin A suppresses tumor promoter 12-O-tetradecanoylphorbol 13-acetate-induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells.	Tetradecanoylphorbol Acetate	39-75	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	97-123
23107437-4	2013	Interestingly, TPA inactivated isocitrate dehydrogenase 1 (IDH1), which was reversed by WA.	Tetradecanoylphorbol Acetate	15-18	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	31-57
23107437-4	2013	Interestingly, TPA inactivated isocitrate dehydrogenase 1 (IDH1), which was reversed by WA.	Tetradecanoylphorbol Acetate	15-18	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	59-63
24048740-7	2014	Downregulation of clathrin by specific siRNAs directed against its heavy chain abolished the effect of alpha-Syn on phorbol 12-myristate 13-acetate-induced DAT internalization.	Tetradecanoylphorbol Acetate	116-147	synuclein, alpha	Mus musculus	103-112
2105714-4	1990	Examination of the purified complexes by SDS/polyacrylamide-gel electrophoresis (SDS/PAGE) and N-terminal amino acid sequence analysis demonstrated that a stoichiometric 1:1 complex is formed between PAI-1 and both forms of tPA.	Tetradecanoylphorbol Acetate	224-227	serpin family E member 1	Homo sapiens	200-205
24220687-11	2014	Thus, knockdown of endogenous HO-1 decreased TPA-induced cell invasion.	Tetradecanoylphorbol Acetate	45-48	heme oxygenase 1	Homo sapiens	30-34
24220687-12	2014	Overall, the results of the present study demonstrate that HO-1 plays a pivotal role in the anti-invasive response of sanguinarine in TPA-stimulated breast cancer cells.	Tetradecanoylphorbol Acetate	134-137	heme oxygenase 1	Homo sapiens	59-63
23107437-9	2013	In addition, we examined the levels of alpha-ketoglutarate, a product of IDH1, and WA blocked its reduction upon TPA treatment.	Tetradecanoylphorbol Acetate	113-116	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	73-77
23017670-5	2013	CD178(+) iTreg increased within 3h after PMA/Ionomycin stimulation in parallel to early apoptotic Annexin(+)/PI(-) PBL, suggesting CD178-mediated apoptosis of responder cells by CD4(+)CD25(+)Foxp3(+)IFNgamma(+)CD178(+) iTreg.	Tetradecanoylphorbol Acetate	41-44	Fas ligand	Homo sapiens	0-5
23333628-3	2013	Recently, we demonstrated that histamine or phorbol-12-myristate-13-acetate (PMA) stimulation induced the up-regulation of H1R gene expression through the protein kinase Cdelta (PKCdelta)/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells expressing H1R endogenously.	Tetradecanoylphorbol Acetate	44-75	histamine receptor H1	Homo sapiens	123-126
23333628-3	2013	Recently, we demonstrated that histamine or phorbol-12-myristate-13-acetate (PMA) stimulation induced the up-regulation of H1R gene expression through the protein kinase Cdelta (PKCdelta)/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells expressing H1R endogenously.	Tetradecanoylphorbol Acetate	77-80	histamine receptor H1	Homo sapiens	123-126
1964062-3	1990	The effect of PTH to block IGF-I stimulated collagen synthesis was observed in the central bone of calvariae and was mimicked by forskolin and phorbol 12-myristate 13-acetate, but not by 1,25-dihydroxyvitamin D3, transforming growth factor-alpha or dexamethasone.	Tetradecanoylphorbol Acetate	143-174	insulin-like growth factor 1	Rattus norvegicus	27-32
23333628-6	2013	In the present study, we examined the effect of quercetin on histamine- and PMA-induced up-regulation of H1R gene expression in HeLa cells.	Tetradecanoylphorbol Acetate	76-79	histamine receptor H1	Homo sapiens	105-108
23440225-6	2013	Facilitation of LTP by PMA (200 nM) was blocked by the nonspecific PKC inhibitor, Ro 31-8220 (10microM); the selective PKCdelta inhibitor, rottlerin (1microM); and the PKCepsilon inhibitor, TAT-epsilonV1-2 peptide (500 nM).	Tetradecanoylphorbol Acetate	23-26	protein kinase C epsilon	Homo sapiens	168-178
24403255-9	2013	Taken together, our results indicate that the course of DMBA/TPA- and MCA-induced carcinogenesis is affected differently by IL-4 versus IL-13-mediated inflammatory cascades.	Tetradecanoylphorbol Acetate	61-64	interleukin 4	Mus musculus	124-128
2197510-3	1990	TPA-treated K562 cells also synthesize and secrete platelet derived growth factor (PDGF), transforming growth factor beta 1 (TGF beta 1), urokinase-plasminogen activator (u-PA) and its specific inhibitor, type 1 plasminogen activator inhibitor (PAI-1).	Tetradecanoylphorbol Acetate	0-3	serpin family E member 1	Homo sapiens	245-250
24070677-8	2013	AQP4 is known to be downregulated by the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) in vivo and in vitro.	Tetradecanoylphorbol Acetate	68-99	aquaporin 4	Rattus norvegicus	0-4
24070677-8	2013	AQP4 is known to be downregulated by the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) in vivo and in vitro.	Tetradecanoylphorbol Acetate	101-104	aquaporin 4	Rattus norvegicus	0-4
22955945-5	2013	RGD-anxA5 enhances engulfment of apoptotic cells by phorbol-12-myristate-13-acetate-stimulated THP-1 (human acute monocytic leukemia cell line) cells in vitro and resident peritoneal mouse macrophages in vivo.	Tetradecanoylphorbol Acetate	52-83	annexin A5	Homo sapiens	4-9
2090920-7	1990	Addition of phorbol 12-myristate 13-acetate (PMA) or IL-4 to the culture of BCL1-B20 cells inhibited both the IL-5-mediated augmentation of IgM secretion and the elevated expression of c-myc mRNA.	Tetradecanoylphorbol Acetate	12-43	interleukin 5	Mus musculus	110-114
23690212-1	2013	TPA (12-O-tetradecanoylphorbol-1, 3-acetate) can induce cell apoptosis and cause PKB (protein kinase B) degradation correlated with its phosphorylation in gastric cancer cells.	Tetradecanoylphorbol Acetate	0-3	protein tyrosine kinase 2 beta	Homo sapiens	81-84
23690212-1	2013	TPA (12-O-tetradecanoylphorbol-1, 3-acetate) can induce cell apoptosis and cause PKB (protein kinase B) degradation correlated with its phosphorylation in gastric cancer cells.	Tetradecanoylphorbol Acetate	0-3	protein tyrosine kinase 2 beta	Homo sapiens	86-102
23690212-4	2013	Moreover, MG132 (26S proteasome inhibitor) partially inhibited TPA-induced degradation of PKB.	Tetradecanoylphorbol Acetate	63-66	protein tyrosine kinase 2 beta	Homo sapiens	90-93
23690212-5	2013	Taken together, TPA could degrade PKB via the ubiquitin-proteasomal pathway, and the suppression of PKB phosphorylation at the serine 473 site might be a prerequisite for the TPA-induced ubiquitination in gastric cancer cells.	Tetradecanoylphorbol Acetate	16-19	protein tyrosine kinase 2 beta	Homo sapiens	34-37
23690212-5	2013	Taken together, TPA could degrade PKB via the ubiquitin-proteasomal pathway, and the suppression of PKB phosphorylation at the serine 473 site might be a prerequisite for the TPA-induced ubiquitination in gastric cancer cells.	Tetradecanoylphorbol Acetate	175-178	protein tyrosine kinase 2 beta	Homo sapiens	100-103
24070677-9	2013	The results in this study displayed that PMA infusion could decrease brain edema accompanied by AQP4 downregulation in ischemic brain.	Tetradecanoylphorbol Acetate	41-44	aquaporin 4	Rattus norvegicus	96-100
24191027-7	2013	Lastly, blocking the proteosomal degradation of MCPIP1 by MG132 abrogated HIV-1 production in phorbol 12-myristate 13-acetate/ionomycin-stimulated human CD4+ T cells isolated from healthy donors.	Tetradecanoylphorbol Acetate	94-125	zinc finger CCCH-type containing 12A	Homo sapiens	48-54
2090920-7	1990	Addition of phorbol 12-myristate 13-acetate (PMA) or IL-4 to the culture of BCL1-B20 cells inhibited both the IL-5-mediated augmentation of IgM secretion and the elevated expression of c-myc mRNA.	Tetradecanoylphorbol Acetate	45-48	interleukin 5	Mus musculus	110-114
1688464-0	1990	Platelet-derived growth factor-stimulated c-myc RNA accumulation in MG-63 human osteosarcoma cells is independent of both protein kinase A and protein kinase C. Treatment of quiescent MG-63 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) or platelet-derived growth factor (PDGF) stimulates the rapid accumulation of c-myc RNA.	Tetradecanoylphorbol Acetate	201-237	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	42-47
24125407-5	2013	In vitro, uPA intensified PMA-induced THP-1 monocyte differentiation, as determined by increased expression of the macrophage marker CD36.	Tetradecanoylphorbol Acetate	26-29	plasminogen activator, urokinase	Mus musculus	10-13
23019217-2	2013	The Mcl-1 promoter activators (TPA) and epidermal growth factor (EGF) enhanced neoplastic transformation of JB6 cells and this response was accompanied by enhanced expression of Mcl-1, and knockdown of Mcl-1 by RNA interference (RNAi) decreased JB6 cell transformation.	Tetradecanoylphorbol Acetate	31-34	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	4-9
23019217-2	2013	The Mcl-1 promoter activators (TPA) and epidermal growth factor (EGF) enhanced neoplastic transformation of JB6 cells and this response was accompanied by enhanced expression of Mcl-1, and knockdown of Mcl-1 by RNA interference (RNAi) decreased JB6 cell transformation.	Tetradecanoylphorbol Acetate	31-34	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	178-183
23019217-2	2013	The Mcl-1 promoter activators (TPA) and epidermal growth factor (EGF) enhanced neoplastic transformation of JB6 cells and this response was accompanied by enhanced expression of Mcl-1, and knockdown of Mcl-1 by RNA interference (RNAi) decreased JB6 cell transformation.	Tetradecanoylphorbol Acetate	31-34	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	178-183
23457529-10	2013	Additionally, in vivo experiments confirmed that COX-2 and COX-2 downstream factors were elevated in TPA-treated Tpl2(-/-) skin, as well as in papillomas from Tpl2(-/-) mice.	Tetradecanoylphorbol Acetate	101-104	mitogen-activated protein kinase kinase kinase 8	Mus musculus	113-117
24135872-8	2013	We found that TPA triggered the formation of a complex between Snail and beta-catenin that activated the Wnt pathway.	Tetradecanoylphorbol Acetate	14-17	catenin beta 1	Homo sapiens	73-85
23957209-1	2013	UNLABELLED: Superoxide production by Nox1, a member of the Nox family NAPDH oxidases, requires expression of its regulatory soluble proteins Noxo1 (Nox organizer 1) and Noxa1 (Nox activator 1) and is markedly enhanced upon cell stimulation with phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	245-276	NADPH oxidase organizer 1	Homo sapiens	141-146
1688464-8	1990	We had previously shown that PDGF action is not affected by prior treatment of MG-63 cells with TPA, a treatment which desensitizes the c-myc response to TPA.	Tetradecanoylphorbol Acetate	154-157	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	136-141
33772987-13	2021	Based on these results, IV tPA should be offered as a treatment for WUS patients with favorable neuroimaging findings.	Tetradecanoylphorbol Acetate	27-30	DnaJ heat shock protein family (Hsp40) member C22	Homo sapiens	68-71
22927445-4	2012	We show that phorbol 12-myristate 13-acetate (PMA)-induced increase in IL-6 production by IL-32alpha-expressing cells was higher than that by empty vector-expressing cells and that this increase occurred in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	13-44	interleukin 32	Homo sapiens	90-100
22927445-4	2012	We show that phorbol 12-myristate 13-acetate (PMA)-induced increase in IL-6 production by IL-32alpha-expressing cells was higher than that by empty vector-expressing cells and that this increase occurred in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	46-49	interleukin 32	Homo sapiens	90-100
23957209-1	2013	UNLABELLED: Superoxide production by Nox1, a member of the Nox family NAPDH oxidases, requires expression of its regulatory soluble proteins Noxo1 (Nox organizer 1) and Noxa1 (Nox activator 1) and is markedly enhanced upon cell stimulation with phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	245-276	NADPH oxidase organizer 1	Homo sapiens	148-163
33824670-12	2020	Conclusion: tPA causes less lipid accumulation in hepatocytes with no detrimental effect on cell viability and might be beneficial for liver cells by the activation of SIRT1 and induction of PPARalpha activity.	Tetradecanoylphorbol Acetate	12-15	peroxisome proliferator activated receptor alpha	Homo sapiens	191-200
23957209-3	2013	Here we show that, in response to PMA, Noxo1 undergoes phosphorylation at multiple sites, which is inhibited by the PKC inhibitor GF109203X.	Tetradecanoylphorbol Acetate	34-37	NADPH oxidase organizer 1	Homo sapiens	39-44
23957209-4	2013	Among them, Thr341 in Noxo1 is directly phosphorylated by PKC in vitro, and alanine substitution for this residue reduces not only PMA-induced Noxo1 phosphorylation but also PMA-dependent enhancement of Nox1-catalyzed superoxide production.	Tetradecanoylphorbol Acetate	131-134	NADPH oxidase organizer 1	Homo sapiens	22-27
23957209-4	2013	Among them, Thr341 in Noxo1 is directly phosphorylated by PKC in vitro, and alanine substitution for this residue reduces not only PMA-induced Noxo1 phosphorylation but also PMA-dependent enhancement of Nox1-catalyzed superoxide production.	Tetradecanoylphorbol Acetate	131-134	NADPH oxidase organizer 1	Homo sapiens	143-148
22773863-0	2012	Inhibiting glycogen synthase kinase-3 decreases 12-O-tetradecanoylphorbol-13-acetate-induced interferon-gamma-mediated skin inflammation.	Tetradecanoylphorbol Acetate	48-84	glycogen synthase kinase 3 beta	Mus musculus	11-37
22773863-2	2012	Because IFN-gamma is involved in inflammatory skin diseases, such as psoriasis, the aim of this study was to investigate the pathogenic role of GSK-3 in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IFN-gamma-mediated ear skin inflammation.	Tetradecanoylphorbol Acetate	153-189	glycogen synthase kinase 3 beta	Mus musculus	144-149
22773863-2	2012	Because IFN-gamma is involved in inflammatory skin diseases, such as psoriasis, the aim of this study was to investigate the pathogenic role of GSK-3 in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IFN-gamma-mediated ear skin inflammation.	Tetradecanoylphorbol Acetate	191-194	glycogen synthase kinase 3 beta	Mus musculus	144-149
23957209-4	2013	Among them, Thr341 in Noxo1 is directly phosphorylated by PKC in vitro, and alanine substitution for this residue reduces not only PMA-induced Noxo1 phosphorylation but also PMA-dependent enhancement of Nox1-catalyzed superoxide production.	Tetradecanoylphorbol Acetate	174-177	NADPH oxidase organizer 1	Homo sapiens	22-27
22773863-4	2012	TPA/IFN-gamma induced GSK-3 activation, which in turn activated signal transducer and activator of transcription 1.	Tetradecanoylphorbol Acetate	0-3	glycogen synthase kinase 3 beta	Mus musculus	22-27
7579165-2	1995	We have shown earlier that phorbol myristate acetate (PMA) completely replaces the red light effect in stimulating nitrate reductase activity and transcript levels in maize.	Tetradecanoylphorbol Acetate	27-52	nitrate reductase [NADH] 1	Zea mays	115-132
22773863-5	2012	Inhibiting GSK-3 pharmacologically, by administering 6-bromoindirubin-3"-oxime (1.5 mug per ear), and genetically, with lentiviral-based short-hairpin RNA, reduced TPA-induced acute skin inflammation but not T-cell infiltration.	Tetradecanoylphorbol Acetate	164-167	glycogen synthase kinase 3 beta	Mus musculus	11-16
22773863-6	2012	It is noteworthy that inhibiting GSK-3 decreased TPA-induced IFN-gamma production and the nuclear translocation of T-box transcription factor Tbx21, a transcription factor of IFN-gamma, in CD3-positive T cells.	Tetradecanoylphorbol Acetate	49-52	glycogen synthase kinase 3 beta	Mus musculus	33-38
22773863-7	2012	In chronic TPA-induced skin inflammation, inhibiting GSK-3 attenuated epidermis hyperproliferation and dermis angiogenesis.	Tetradecanoylphorbol Acetate	11-14	glycogen synthase kinase 3 beta	Mus musculus	53-58
22773863-8	2012	These results demonstrate the dual role of GSK-3 in TPA-induced skin inflammation that is not only to facilitate IFN-gamma signaling but also to regulate IFN-gamma production.	Tetradecanoylphorbol Acetate	52-55	glycogen synthase kinase 3 beta	Mus musculus	43-48
23770196-7	2013	Furthermore, topical application of PEP-1-SIRT2 to 12-O-tetradecanoylphorbol 13-acetate-treated mouse ears markedly inhibited expression levels of COX-2 and proinflammatory cytokines as well as the activation of NF-kappaB and MAPKs.	Tetradecanoylphorbol Acetate	51-87	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	36-41
23770196-7	2013	Furthermore, topical application of PEP-1-SIRT2 to 12-O-tetradecanoylphorbol 13-acetate-treated mouse ears markedly inhibited expression levels of COX-2 and proinflammatory cytokines as well as the activation of NF-kappaB and MAPKs.	Tetradecanoylphorbol Acetate	51-87	sirtuin 2	Mus musculus	42-47
23913682-5	2013	12-O-Tetradecanoylphorbol-13-acetate induced the expression of both KLF5 and mPGES1 in dosage- and time-dependent manners.	Tetradecanoylphorbol Acetate	0-36	prostaglandin E synthase	Mus musculus	77-83
7579165-2	1995	We have shown earlier that phorbol myristate acetate (PMA) completely replaces the red light effect in stimulating nitrate reductase activity and transcript levels in maize.	Tetradecanoylphorbol Acetate	54-57	nitrate reductase [NADH] 1	Zea mays	115-132
23913682-6	2013	The induction of KLF5 was essential for 12-O-tetradecanoylphorbol-13-acetate to induce mPGES1 expression.	Tetradecanoylphorbol Acetate	40-76	prostaglandin E synthase	Mus musculus	87-93
7818761-1	1995	This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain.	Tetradecanoylphorbol Acetate	102-138	FBJ osteosarcoma oncogene	Mus musculus	166-171
22920671-2	2012	We found that brazilin inhibited the mRNA and protein expression of interleukin (IL)-4 and IL-5 induced by phorbol myristate acetate (PMA) and cAMP in EL-4 T cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	107-132	interleukin 4	Mus musculus	68-86
22920671-2	2012	We found that brazilin inhibited the mRNA and protein expression of interleukin (IL)-4 and IL-5 induced by phorbol myristate acetate (PMA) and cAMP in EL-4 T cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	107-132	interleukin 5	Mus musculus	91-95
22920671-2	2012	We found that brazilin inhibited the mRNA and protein expression of interleukin (IL)-4 and IL-5 induced by phorbol myristate acetate (PMA) and cAMP in EL-4 T cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	134-137	interleukin 4	Mus musculus	68-86
22920671-2	2012	We found that brazilin inhibited the mRNA and protein expression of interleukin (IL)-4 and IL-5 induced by phorbol myristate acetate (PMA) and cAMP in EL-4 T cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	134-137	interleukin 5	Mus musculus	91-95
7818761-1	1995	This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain.	Tetradecanoylphorbol Acetate	102-138	jun B proto-oncogene	Mus musculus	180-184
7818761-1	1995	This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain.	Tetradecanoylphorbol Acetate	140-143	FBJ osteosarcoma oncogene	Mus musculus	166-171
7818761-1	1995	This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain.	Tetradecanoylphorbol Acetate	140-143	jun B proto-oncogene	Mus musculus	180-184
22441738-6	2012	Inhibitors of 12-LOX, but not those of COX, 5-LOX or 15-LOX, reduce MUC5AC expression induced by phorbol myristate acetate (PMA) in the bronchial epithelial cell line NCI-H292.	Tetradecanoylphorbol Acetate	97-122	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	68-74
22441738-6	2012	Inhibitors of 12-LOX, but not those of COX, 5-LOX or 15-LOX, reduce MUC5AC expression induced by phorbol myristate acetate (PMA) in the bronchial epithelial cell line NCI-H292.	Tetradecanoylphorbol Acetate	124-127	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	68-74
23994577-4	2013	In addition, 12-O-tetradecanoylphorbol-13-acetate (TPA) known to differentiate SH-SY5Y cells into a neuronal phenotype and to increase NPY expression through activation of protein kinase C (PKC) was applied as a positive control (16nM).	Tetradecanoylphorbol Acetate	51-54	neuropeptide Y	Homo sapiens	135-138
7818761-6	1995	In contrast, two treatments of SSIN mice with TPA caused a rapid, strong c-fos induction 1-2 h after treatment, whereas C57BL/6 mice responded no more strongly than after a single treatment.	Tetradecanoylphorbol Acetate	46-49	FBJ osteosarcoma oncogene	Mus musculus	73-78
23994577-8	2013	A further increase in expression was observed with simultaneous VPA and TPA treatment, suggesting that the two agents may increase NPY expression through different mechanisms.	Tetradecanoylphorbol Acetate	72-75	neuropeptide Y	Homo sapiens	131-134
34968577-13	2022	Treatment of HK-2 cells with ERK-specific inhibitor SCH772984 and agonist TPA validated LMCD1 exerted its function via activating ERK signaling.	Tetradecanoylphorbol Acetate	74-77	LIM and cysteine-rich domains 1	Mus musculus	88-93
23994577-9	2013	The increase in NPY mRNA by VPA and TPA was confirmed with qRT-PCR after 72h.	Tetradecanoylphorbol Acetate	36-39	neuropeptide Y	Homo sapiens	16-19
22572817-4	2012	alpha-Melanocortin and forskolin, which activate adenylate cyclase, and 12-O-tetradecanoylphorbol-13-acetate, which activates protein kinase C, increased, whereas exposure to UV radiation reduced, MC1R gene and membrane protein expression.	Tetradecanoylphorbol Acetate	72-108	melanocortin 1 receptor	Homo sapiens	197-201
24062859-8	2013	Finally, HMGA1 binding affinity to DNA was found to be influenced by the DNA A:T segment sequence context, with higher specificity be observed in HMGA1 binding to TnAn segments, which have two local minor groove minima on either side of the TpA step, compared to An:Tn segments, which have a single minor groove minimum at the 3" end of the An run, implying AT-hook binding favors narrow minor groove structure.	Tetradecanoylphorbol Acetate	241-244	high mobility group AT-hook 1	Homo sapiens	9-14
34884902-2	2021	We recently reported that the small molecule inhibitors, TPCA-1 and IKK-16, which target nuclear factor kappaB (NF-kappaB) activation, moderately reduced Eomes-dependent IFN-gamma expression in mouse lymphoma BW5147 cells stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	238-269	eomesodermin	Mus musculus	154-159
24062859-8	2013	Finally, HMGA1 binding affinity to DNA was found to be influenced by the DNA A:T segment sequence context, with higher specificity be observed in HMGA1 binding to TnAn segments, which have two local minor groove minima on either side of the TpA step, compared to An:Tn segments, which have a single minor groove minimum at the 3" end of the An run, implying AT-hook binding favors narrow minor groove structure.	Tetradecanoylphorbol Acetate	241-244	high mobility group AT-hook 1	Homo sapiens	146-151
23775412-5	2013	The expression of PAR4 in cultured DRG neurons was also assessed after treatment with IL-1beta with pre-addition of phorbol-12-myristate 13-acetate (PMA, a PKC activator) or chelerythrine chloride (a PKC inhibitor).	Tetradecanoylphorbol Acetate	116-147	F2R like thrombin or trypsin receptor 3	Rattus norvegicus	18-22
22316125-7	2012	PKC activator phorbol 12-myristate 13-acetate enhanced EGFR tyrosyl phosphorylation and upregulated the gene expression of growth factors and cytokines in a heparin-binding EGF-like growth factor (HBEGF) inhibitor CRM197 sensitive manner, indicating an involvement of autocrined HBEGF in the downstream of PKC signaling.	Tetradecanoylphorbol Acetate	14-45	heparin binding EGF like growth factor	Homo sapiens	157-195
22316125-7	2012	PKC activator phorbol 12-myristate 13-acetate enhanced EGFR tyrosyl phosphorylation and upregulated the gene expression of growth factors and cytokines in a heparin-binding EGF-like growth factor (HBEGF) inhibitor CRM197 sensitive manner, indicating an involvement of autocrined HBEGF in the downstream of PKC signaling.	Tetradecanoylphorbol Acetate	14-45	heparin binding EGF like growth factor	Homo sapiens	197-202
22316125-7	2012	PKC activator phorbol 12-myristate 13-acetate enhanced EGFR tyrosyl phosphorylation and upregulated the gene expression of growth factors and cytokines in a heparin-binding EGF-like growth factor (HBEGF) inhibitor CRM197 sensitive manner, indicating an involvement of autocrined HBEGF in the downstream of PKC signaling.	Tetradecanoylphorbol Acetate	14-45	heparin binding EGF like growth factor	Homo sapiens	279-284
34884902-2	2021	We recently reported that the small molecule inhibitors, TPCA-1 and IKK-16, which target nuclear factor kappaB (NF-kappaB) activation, moderately reduced Eomes-dependent IFN-gamma expression in mouse lymphoma BW5147 cells stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	271-274	eomesodermin	Mus musculus	154-159
34884902-7	2021	In effector CD4+ and CD8+ T cells activated with anti-CD3 and anti-CD28 antibodies, IFN-gamma expression induced by PMA and A23187 was not markedly decreased by TPCA-1 or IKK-16 under conditions where IL-2 expression was markedly reduced.	Tetradecanoylphorbol Acetate	116-119	CD28 antigen	Mus musculus	67-71
23814099-4	2013	We observed that the phosphorylation of C/EBPalpha Ser-21 was inhibited by a PKCdelta-specific inhibitor, rottlerin, or IL-32beta knockdown by siRNA and that IL-32beta shifted to the membrane from the cytosol upon phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	214-245	interleukin 32	Homo sapiens	158-167
22617836-8	2012	CCK/TPA stimulated the association of Yes with focal adhesion kinases (Pyk2, FAK) and its autophosphorylated forms (pY397FAK, pY402Pyk2).	Tetradecanoylphorbol Acetate	4-7	protein tyrosine kinase 2	Rattus norvegicus	77-80
34675296-16	2021	Canine Tregs also constitutively expressed CTLA4, and stimulation with PMA/Ionomycin dramatically increased expression of CTLA4 on the cell surface.	Tetradecanoylphorbol Acetate	71-74	cytotoxic T-lymphocyte associated protein 4	Canis lupus familiaris	122-127
22533343-4	2012	Our studies demonstrate that both the tumor promoter TPA and UVC irradiation decreased expression and activity levels of IDH1, not IDH2, in the tumor promotable JB6 P+ cell model.	Tetradecanoylphorbol Acetate	53-56	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	121-125
22533343-5	2012	Skin epidermal tissues treated with dimethylbenz[alpha]anthracene/TPA also showed decreases in IDH1 expression and activity.	Tetradecanoylphorbol Acetate	66-69	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	95-99
22533343-6	2012	In non-promotable JB6 P-cells, IDH1 was upregulated upon TPA treatment, whereas IDH2 was maintained at similar levels with TPA treatment.	Tetradecanoylphorbol Acetate	57-60	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	31-35
22533343-7	2012	Interestingly, IDH1 knockdown enhanced, whereas IDH1 overexpression suppressed, TPA-induced cell transformation.	Tetradecanoylphorbol Acetate	80-83	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	15-19
22533343-7	2012	Interestingly, IDH1 knockdown enhanced, whereas IDH1 overexpression suppressed, TPA-induced cell transformation.	Tetradecanoylphorbol Acetate	80-83	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	48-52
23977008-5	2013	To investigate the mechanistic links between PTTG1 overexpression and leukemia cell differentiation, we utilized phorbol 12-myristate 13-acetate (PMA), a well-known agent that triggers monocyte/macrophage differentiation, to analyze the expression patterns of PTTG1 in PMA-induced myeloid differentiation.	Tetradecanoylphorbol Acetate	146-149	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	45-50
34675601-9	2021	Conclusion: These results revealed the inducible expression of PD-L1/PD-1 in PMA-induced THP-1-differentiated M0 macrophages followed by a decrease in M2 macrophages.	Tetradecanoylphorbol Acetate	77-80	CD274 molecule	Homo sapiens	63-68
23977008-5	2013	To investigate the mechanistic links between PTTG1 overexpression and leukemia cell differentiation, we utilized phorbol 12-myristate 13-acetate (PMA), a well-known agent that triggers monocyte/macrophage differentiation, to analyze the expression patterns of PTTG1 in PMA-induced myeloid differentiation.	Tetradecanoylphorbol Acetate	146-149	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	260-265
23977008-9	2013	In HL-60 and THP1 cells, KLF6 mRNA and protein levels are up-regulated with a concordant reduction of PTTG1 expression upon treatment with PMA.	Tetradecanoylphorbol Acetate	139-142	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	102-107
23977008-11	2013	The protein kinase C (PKC) inhibitor and the MAPK/ERK kinase (MEK) inhibitor significantly blocked the potentiation of PMA-mediated KLF6 induction and the down-regulation of PTTG1, indicating that PTTG1 is suppressed via the activation of PKC/ERK/KLF6 pathway.	Tetradecanoylphorbol Acetate	119-122	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	197-202
22627769-5	2012	To assess whether T-plastin expression was inducible, T-plastin-negative PBLs were stimulated by phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	97-128	plastin 3	Homo sapiens	54-63
34638484-4	2021	Loss of function of Ccrl2 accelerated the development of papillomas in a chemical model of skin carcinogenesis (DMBA/TPA), whereas the growth of B16 and LLC tumor cell grafts was delayed.	Tetradecanoylphorbol Acetate	117-120	chemokine (C-C motif) receptor-like 2	Mus musculus	20-25
24009824-0	2012	Suppression of Transglutaminase-2 is Involved in Anti-Inflammatory Actions of Glucosamine in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation.	Tetradecanoylphorbol Acetate	93-129	transglutaminase 2, C polypeptide	Mus musculus	15-33
24009824-4	2012	TPA-induced ear edema was evoked in ICR or transglutaminase 2 (Tgase-2) (-/-) mice.	Tetradecanoylphorbol Acetate	0-3	transglutaminase 2, C polypeptide	Mus musculus	43-61
24009824-4	2012	TPA-induced ear edema was evoked in ICR or transglutaminase 2 (Tgase-2) (-/-) mice.	Tetradecanoylphorbol Acetate	0-3	transglutaminase 2, C polypeptide	Mus musculus	63-70
23615401-8	2013	HO-1 end products, such as carbon monoxide, free iron and bilirubin, suppressed the TPA-induced MMP-9 mRNA and protein expression, enzyme activity, migration and invasion in MCF-7 cells.	Tetradecanoylphorbol Acetate	84-87	heme oxygenase 1	Homo sapiens	0-4
23615401-9	2013	Furthermore, TPA-induced extracellular signal-regulated kinase (ERK) 1/2 and Akt phosphorylation and the DNA binding activity of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) were attenuated by pretreatment with AP and HO-1 end products.	Tetradecanoylphorbol Acetate	13-16	heme oxygenase 1	Homo sapiens	239-243
23615401-11	2013	Additionally, induction of HO-1 expression is at least partially involved in the inhibition of TPA-induced MMP-9 activation and cell migration in MCF-7 cells by AP.	Tetradecanoylphorbol Acetate	95-98	heme oxygenase 1	Homo sapiens	27-31
24009824-7	2012	Role of Tgase-2 in TPA ear edema is examined using Tgase-2 (-/-) mice and TPA did not induce COX-2 expression in ear of Tgase-2 (-/-) mice.	Tetradecanoylphorbol Acetate	19-22	transglutaminase 2, C polypeptide	Mus musculus	8-15
34369554-9	2021	On the other hand, AGFG2 downregulation resulted in the inhibition of vWF secretion upon Phorbol 12-myristate 13-acetate (PMA) or histamine stimulation, suggesting that AGFG2 plays a role in vWF exocytosis.	Tetradecanoylphorbol Acetate	89-120	ArfGAP with FG repeats 2	Homo sapiens	19-24
24009824-8	2012	These observations suggested that Tgase-2 is involved in TPA-induced COX-2 expression in the inflamed ear of mice and anti-inflammatory effects of glucosamine is mediated through suppression of Tgase-2 in TPA ear edema.	Tetradecanoylphorbol Acetate	57-60	transglutaminase 2, C polypeptide	Mus musculus	34-41
24009824-8	2012	These observations suggested that Tgase-2 is involved in TPA-induced COX-2 expression in the inflamed ear of mice and anti-inflammatory effects of glucosamine is mediated through suppression of Tgase-2 in TPA ear edema.	Tetradecanoylphorbol Acetate	205-208	transglutaminase 2, C polypeptide	Mus musculus	194-201
23562609-7	2013	During SIRPalpha induction, levels of these 3 miRNAs were all reduced, and their downregulation by retinoic acid or phorbol 12-myristate 13-acetate occurred through suppression of the c-Myc signaling pathway.	Tetradecanoylphorbol Acetate	116-147	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	184-189
34369554-9	2021	On the other hand, AGFG2 downregulation resulted in the inhibition of vWF secretion upon Phorbol 12-myristate 13-acetate (PMA) or histamine stimulation, suggesting that AGFG2 plays a role in vWF exocytosis.	Tetradecanoylphorbol Acetate	89-120	ArfGAP with FG repeats 2	Homo sapiens	169-174
22505246-3	2012	The results showed that TPA- and endothelial growth factor (EGF)-induced anchorage-independent colony formation were suppressed in a dose-dependent manner by treatment of JB6 CI41 mouse skin epidermal cells with juglone (2.5 and 5 microM).	Tetradecanoylphorbol Acetate	24-27	epidermal growth factor	Homo sapiens	60-63
34369554-9	2021	On the other hand, AGFG2 downregulation resulted in the inhibition of vWF secretion upon Phorbol 12-myristate 13-acetate (PMA) or histamine stimulation, suggesting that AGFG2 plays a role in vWF exocytosis.	Tetradecanoylphorbol Acetate	122-125	ArfGAP with FG repeats 2	Homo sapiens	19-24
34369554-9	2021	On the other hand, AGFG2 downregulation resulted in the inhibition of vWF secretion upon Phorbol 12-myristate 13-acetate (PMA) or histamine stimulation, suggesting that AGFG2 plays a role in vWF exocytosis.	Tetradecanoylphorbol Acetate	122-125	ArfGAP with FG repeats 2	Homo sapiens	169-174
23715767-6	2013	The expression of Egr-1, p21 and JNK was strongly increased after treatment of the cells with TPA, tumor necrosis factor-alpha (TNF-alpha) or arsenite.	Tetradecanoylphorbol Acetate	94-97	early growth response 1	Homo sapiens	18-23
23775084-5	2013	We show that both chemical suppression and siRNA silencing of PP2Ac in T-cells resulted in sustained phosphorylation of MEK and ERK following stimulation with phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	159-190	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	62-67
23399806-9	2013	Further, TPA induced altered expression of NF-kappaB (p65) and COX-2 was also attenuated by GOH.	Tetradecanoylphorbol Acetate	9-12	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	54-57
34289257-5	2021	Interleukin (IL) 1beta, IL6, and tumor necrosis factor (TNF) alpha messenger RNA (mRNA) expressions were analyzed in freshly isolated and cultured PBMCs with phytohemagglutinin and phorbol myristate acetate stimulation by real-time reverse transcription polymerase chain reaction and serum MMP3 by enzyme-linked immunosorbent assay (ELISA).	Tetradecanoylphorbol Acetate	181-206	interleukin 1 alpha	Homo sapiens	0-22
23702712-11	2013	ANX A2 depletion significantly inhibited TNF-alpha shedding by interleukin-1beta and TPA.	Tetradecanoylphorbol Acetate	85-88	annexin A2	Homo sapiens	0-6
23702712-14	2013	CONCLUSIONS: ANX A2 was closely associated with ADAM17 and played an important role in TNF-alpha shedding by TPA.	Tetradecanoylphorbol Acetate	109-112	annexin A2	Homo sapiens	13-19
34146852-3	2021	This study aims to clarify an anti-inflammatory effect of CQ through modulating TSLP levels using an in vitro model of phorbol myristate acetate (PMA) + A23187-activated human mast cell line (HMC-1) and an in vivo model of PMA-irritated ear edema.	Tetradecanoylphorbol Acetate	119-144	thymic stromal lymphopoietin	Homo sapiens	80-84
34146852-3	2021	This study aims to clarify an anti-inflammatory effect of CQ through modulating TSLP levels using an in vitro model of phorbol myristate acetate (PMA) + A23187-activated human mast cell line (HMC-1) and an in vivo model of PMA-irritated ear edema.	Tetradecanoylphorbol Acetate	146-149	thymic stromal lymphopoietin	Homo sapiens	80-84
22751111-6	2013	Thus, GPR55-deficient mice were more resistant to DMBA/TPA-induced papilloma and carcinoma formation than their wild-type littermates.	Tetradecanoylphorbol Acetate	55-58	G protein-coupled receptor 55	Mus musculus	6-11
34114342-3	2021	Treatment of human myometrial cells with the pro-inflammatory mediators, lipopolysaccharide (LPS, mimicking infection) and 12-O-tetradecanoylphorbol-13-acetate (TPA, mimicking inflammation), induced 20alpha-HSD gene expression and increased 20alpha-HSD protein abundance.	Tetradecanoylphorbol Acetate	123-159	hydroxysteroid 17-beta dehydrogenase 2	Homo sapiens	199-210
23589174-8	2013	SBI-0089410 inhibited the 12-O-tetradecanoylphorbol-l3-acetate (TPA)-induced membrane translocation of protein kinase C (PKC) isoforms, whereas both compounds decreased ATF2 phosphorylation by PKCepsilon and ATF2 transcriptional activity.	Tetradecanoylphorbol Acetate	64-67	protein kinase C epsilon	Homo sapiens	121-124
23589174-8	2013	SBI-0089410 inhibited the 12-O-tetradecanoylphorbol-l3-acetate (TPA)-induced membrane translocation of protein kinase C (PKC) isoforms, whereas both compounds decreased ATF2 phosphorylation by PKCepsilon and ATF2 transcriptional activity.	Tetradecanoylphorbol Acetate	64-67	protein kinase C epsilon	Homo sapiens	193-203
34114342-3	2021	Treatment of human myometrial cells with the pro-inflammatory mediators, lipopolysaccharide (LPS, mimicking infection) and 12-O-tetradecanoylphorbol-13-acetate (TPA, mimicking inflammation), induced 20alpha-HSD gene expression and increased 20alpha-HSD protein abundance.	Tetradecanoylphorbol Acetate	161-164	hydroxysteroid 17-beta dehydrogenase 2	Homo sapiens	199-210
34114342-5	2021	The NF-kB /AP-1 transcription factors mediated effects of LPS and TPA on 20alpha-HSD gene transcription.	Tetradecanoylphorbol Acetate	66-69	hydroxysteroid 17-beta dehydrogenase 2	Homo sapiens	73-84
23266722-3	2013	The sequential administration of DMBA and TPA leads to the appearance of a large number of benign papillomas, of which some convert later into invasive squamous cell carcinomas (SCC).	Tetradecanoylphorbol Acetate	42-45	serpin family B member 3	Homo sapiens	178-181
34114342-6	2021	Both pro-inflammatory stimuli induced 20alpha-HSD promoter activity in LPS/TPA-treated cells which was significantly attenuated by inhibition of NF-kB (JSH: 20 microM) or AP-1 signalling (T5224: 10 microM).	Tetradecanoylphorbol Acetate	75-78	hydroxysteroid 17-beta dehydrogenase 2	Homo sapiens	38-49
23288142-0	2013	Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	108-144	heme oxygenase 1	Homo sapiens	88-104
34114342-7	2021	Deletion of NF-kB consensus sites abrogated LPS-mediated promoter induction, while removal of AP-1 sites reversed the TPA-mediated induction of 20alpha-HSD promoter.	Tetradecanoylphorbol Acetate	118-121	hydroxysteroid 17-beta dehydrogenase 2	Homo sapiens	144-155
34204745-11	2021	Furthermore, the XN-treatment counteracted the PMA-induced EMT of the A549 cells by the upregulation of E-cadherin and alpha-E-catenin and the downregulation of N-cadherin, vimentin, and Snail-1 expression.	Tetradecanoylphorbol Acetate	47-50	vimentin	Homo sapiens	173-181
23322165-4	2013	Here, however, we demonstrate that phorbol myristate acetate (PMA) stimulates NOXO1 phosphorylation in a transfected human embryonic kidney (HEK) 293 epithelial cell model via protein kinase C and identify Ser-154 as the major phosphorylated site.	Tetradecanoylphorbol Acetate	35-60	NADPH oxidase organizer 1	Homo sapiens	78-83
23322165-4	2013	Here, however, we demonstrate that phorbol myristate acetate (PMA) stimulates NOXO1 phosphorylation in a transfected human embryonic kidney (HEK) 293 epithelial cell model via protein kinase C and identify Ser-154 as the major phosphorylated site.	Tetradecanoylphorbol Acetate	62-65	NADPH oxidase organizer 1	Homo sapiens	78-83
34135890-8	2021	The formation of Rab10-positive tubules from premacropinosomes was also observed in control and phorbol myristate acetate (PMA)-stimulated macrophages, although their frequencies were low.	Tetradecanoylphorbol Acetate	96-121	RAB10, member RAS oncogene family	Homo sapiens	17-22
23353996-4	2013	To verify the regulatory mechanism of TPA-induced             MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126,             and TPA-induced MMP-9 expression was significantly decreased.	Tetradecanoylphorbol Acetate	162-165	mitogen-activated protein kinase kinase 1	Homo sapiens	121-127
34135890-8	2021	The formation of Rab10-positive tubules from premacropinosomes was also observed in control and phorbol myristate acetate (PMA)-stimulated macrophages, although their frequencies were low.	Tetradecanoylphorbol Acetate	123-126	RAB10, member RAS oncogene family	Homo sapiens	17-22
35304248-4	2022	We report that P2ry6-deficient mice exhibit marked resistance to DMBA/TPA-induced skin papilloma formation compared with wild-type mice.	Tetradecanoylphorbol Acetate	70-73	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	15-20
23512660-3	2013	Reduced exposure to TPA-induced chronic inflammation causes a dramatic reduction in classical papillomas and squamous cell carcinomas (SCCs), but the mice still develop highly invasive carcinomas with EMT properties, reduced levels of Hras and Egfr signaling, and frequent Ink4/Arf deletions.	Tetradecanoylphorbol Acetate	20-23	epidermal growth factor receptor	Mus musculus	244-248
35304248-5	2022	Consistent with these findings, epidermal hyperplasia in response to TPA was suppressed in the P2ry6 knockout or MRS2578 (P2RY6 antagonist)-treated mice.	Tetradecanoylphorbol Acetate	69-72	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	95-100
35304248-5	2022	Consistent with these findings, epidermal hyperplasia in response to TPA was suppressed in the P2ry6 knockout or MRS2578 (P2RY6 antagonist)-treated mice.	Tetradecanoylphorbol Acetate	69-72	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	122-127
23269677-3	2013	The studies herein demonstrate that the human meprin alpha transcript is bound and stabilized by Hu antigen R at baseline, and that treatment with the inflammatory stimulus phorbol 12-myristate 13-acetate downregulates meprin alpha expression by inducing tristetraprolin.	Tetradecanoylphorbol Acetate	173-204	ELAV like RNA binding protein 1	Homo sapiens	97-109
23333628-8	2013	Quercetin suppressed histamine- and PMA-induced up-regulation of H1R gene expression.	Tetradecanoylphorbol Acetate	36-39	histamine receptor H1	Homo sapiens	65-68
35304248-6	2022	The dramatic decrease in hyperplasia and tumorigenesis due to P2ry6 disruption was associated with the suppression of TPA-induced keratinocyte proliferation and inflammatory reactions.	Tetradecanoylphorbol Acetate	118-121	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	62-67
35304248-7	2022	Notably, P2ry6 deletion prevented the TPA-induced increase in YAP nuclear accumulation and its downstream gene expression in an MST/LATS1-dependent manner.	Tetradecanoylphorbol Acetate	38-41	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	9-14
35304248-8	2022	Upon TPA stimulation, enhanced activation of MEK1 and beta-catenin were also impaired in P2ry6 knockout primary keratinocytes, tumor tissues or MRS2578-treated HaCaT cells.	Tetradecanoylphorbol Acetate	5-8	mitogen-activated protein kinase kinase 1	Homo sapiens	45-49
35304248-8	2022	Upon TPA stimulation, enhanced activation of MEK1 and beta-catenin were also impaired in P2ry6 knockout primary keratinocytes, tumor tissues or MRS2578-treated HaCaT cells.	Tetradecanoylphorbol Acetate	5-8	catenin beta 1	Homo sapiens	54-66
35304248-8	2022	Upon TPA stimulation, enhanced activation of MEK1 and beta-catenin were also impaired in P2ry6 knockout primary keratinocytes, tumor tissues or MRS2578-treated HaCaT cells.	Tetradecanoylphorbol Acetate	5-8	pyrimidinergic receptor P2Y6	Homo sapiens	89-94
35304248-9	2022	Moreover, mutual promotion of the YAP and beta-catenin signaling pathways was observed in normal skin cells treated with TPA, while P2ry6 deletion could inhibit their crosstalk by regulating MEK1.	Tetradecanoylphorbol Acetate	121-124	catenin beta 1	Homo sapiens	42-54
35185884-10	2022	Our analyses showed that phorbol myristate acetate/ionomycin stimulation of PBMC induced significant expression of IL-17A by CD3+ T cells as detected by several of our mAbs.	Tetradecanoylphorbol Acetate	25-50	interleukin-17A	Sus scrofa	115-121
23725168-4	2013	Forced expression of Homer3 in transfected K562 cells inhibited proliferation, influenced the cell cycle profile, affected apoptosis induced by As2O3 through inhibition of Bcl2 expression, and also promoted cell differentiation induced by 12-O-tetra decanoylphorbol-acetate (TPA).	Tetradecanoylphorbol Acetate	275-278	homer scaffold protein 3	Homo sapiens	21-27
23573299-7	2013	Likewise, GrB-T was released into the extracellular space upon induction of degranulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	95-98	granzyme B	Homo sapiens	10-13
35068054-5	2022	Mechanistic analyses suggested that the PPP2CB deletion enhanced activation of the PI3K/Akt signaling pathway and Ca2+ flux following stimulation with PMA plus ionomycin.	Tetradecanoylphorbol Acetate	151-154	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	Mus musculus	40-46
23105116-8	2012	To further evaluate the functional role of Trx-1, we used a heparin-binding EGF shedding cell model and observed that the overexpression of Trx-1 in HEK293 cells could decrease the activity of ADAM17, activated by either phorbol 12-myristate 13-acetate or EGF.	Tetradecanoylphorbol Acetate	221-252	thioredoxin	Homo sapiens	140-145
35068054-8	2022	Collectively, our study provides evidence of the specific role of PPP2CB in controlling PMA plus ionomycin-induced T cell activation.	Tetradecanoylphorbol Acetate	88-91	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	Mus musculus	66-72
23105117-5	2012	VRK2 increases NFAT1-dependent transcription by phosphorylation, and this effect is only detected following cell phorbol 12-myristate 13-acetate and ionomycin stimulation and calcineurin activation.	Tetradecanoylphorbol Acetate	113-144	nuclear factor of activated T cells 2	Homo sapiens	15-20
35043283-9	2022	Transcriptomic RNA-seq showed that FX abrogated TPA-induced differentially expressed genes (DEGs) of Nfe2l2-related genes Nqo1, Ho1, and Keap1.	Tetradecanoylphorbol Acetate	48-51	heme oxygenase 1	Homo sapiens	128-131
23041978-1	2012	In the present study, the effects of 12-O-tetra-decanoylphorbol-13-acetate             (TPA) alone or in combination with gemcitabine on the growth of Panc-1 pancreatic             cancer cells cultured in vitro or grown in NCr immunodeficient nude mice were             investigated.	Tetradecanoylphorbol Acetate	88-91	pancreas protein 1	Mus musculus	151-157
2513129-3	1989	However, cotransfection of c-jun and jun-B into primary rat embryo cells with c-Ha-ras results in a significant decrease in transformation compared with c-jun alone, an event reversed by TPA.	Tetradecanoylphorbol Acetate	187-190	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	37-42
23041978-2	2012	Combinations of TPA and gemcitabine synergi-stically inhibited the             growth and induced apoptosis in Panc-1 cells.	Tetradecanoylphorbol Acetate	16-19	pancreas protein 1	Mus musculus	111-117
23041978-3	2012	The combination of TPA (0.16 nM)             and gemcitabine (0.5 microM) induced a marked increase in phosphorylated c-Jun NH2-terminal             kinase (JNK) in the Panc-1 cells.	Tetradecanoylphorbol Acetate	19-22	pancreas protein 1	Mus musculus	169-175
2556385-0	1989	Activation of the serum response element and 12-O-tetradecanoylphorbol-13-acetate response element by the activated c-raf-1 protein in a manner independent of protein kinase C. Transfection of the cDNA encoding the activated c-raf-1 protein or addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) or dibutyryl cAMP to NIH/3T3 cells activated the c-fos gene enhancer linked to the chloramphenicol acetyltransferase or luciferase reporter gene.	Tetradecanoylphorbol Acetate	45-81	FBJ osteosarcoma oncogene	Mus musculus	348-353
22475810-10	2012	VK2 suppressed the PKCalpha kinase activity and the phosphorylation of PKCe after TPA treatment, but neither the activation nor the enzyme activity of PKCdelta was affected.	Tetradecanoylphorbol Acetate	82-85	protein kinase C epsilon	Homo sapiens	71-75
22475810-11	2012	The knockdown of PKCe abolished the TPA-induced phosphorylation of PKD1, and the effects of PKD1 knockdown on NF-kappaB activation were similar to those of PKCe knockdown.	Tetradecanoylphorbol Acetate	36-39	protein kinase C epsilon	Homo sapiens	17-21
22475810-11	2012	The knockdown of PKCe abolished the TPA-induced phosphorylation of PKD1, and the effects of PKD1 knockdown on NF-kappaB activation were similar to those of PKCe knockdown.	Tetradecanoylphorbol Acetate	36-39	polycystin 1, transient receptor potential channel interacting	Homo sapiens	67-71
2684398-3	1989	In TPA-treated cells, the activities of anabolic enzymes thymidine kinase (EC 2.7.1.75)and thymidylate synthase (EC 2.1.1.45) declined with time linearly to 20 and 16% of those of untreated cells by 72 h. Incorporation of [3H]thymidine and [3H]deoxyuridine into acid-insoluble fractions also decreased in parallel with the decline in enzyme activities.	Tetradecanoylphorbol Acetate	3-6	thymidylate synthetase	Homo sapiens	91-111
22475810-12	2012	Collectively, all of the PKCs, including alpha, delta and e, and PKD1 are involved in the TPA-mediated activation of NF-kappaB.	Tetradecanoylphorbol Acetate	90-93	polycystin 1, transient receptor potential channel interacting	Homo sapiens	65-69
2558432-6	1989	In addition, EGF, insulin, and TPA, like hCG, elevated mRNA levels of competence oncogenes (c-fos and c-myc), albeit to different extents.	Tetradecanoylphorbol Acetate	31-34	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	102-107
23285695-5	2012	Phorbol-12-myristate 13-acetate (PMA) is a well-known inflammatory stimulator and tumor promoter that activates PKC and increases the invasiveness of various types of cancer cells by activating MMPs.	Tetradecanoylphorbol Acetate	0-31	matrix metallopeptidase 1	Homo sapiens	194-198
23285695-5	2012	Phorbol-12-myristate 13-acetate (PMA) is a well-known inflammatory stimulator and tumor promoter that activates PKC and increases the invasiveness of various types of cancer cells by activating MMPs.	Tetradecanoylphorbol Acetate	33-36	matrix metallopeptidase 1	Homo sapiens	194-198
2601720-0	1989	Transcriptional induction of the murine c-rel gene with serum and phorbol-12-myristate-13-acetate in fibroblasts.	Tetradecanoylphorbol Acetate	66-97	reticuloendotheliosis oncogene	Mus musculus	40-45
23285695-12	2012	Caco-2 treated with both PMA and IP6 showed a significant decrease in MMP-1 expression in comparison to PMA-stimulated cells.	Tetradecanoylphorbol Acetate	25-28	matrix metallopeptidase 1	Homo sapiens	70-75
2601720-1	1989	Transcription of the c-rel proto-oncogene was induced transiently when resting mouse NIH 3T3 fibroblasts were stimulated with serum or phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	135-166	reticuloendotheliosis oncogene	Mus musculus	21-26
2481744-8	1989	In contrast, 12-O-tetradencanoylphorbol-13-acetate (TPA), which is known to downregulate EGF receptors by blocking their protein tyrosine kinase, produced dissimilar end results.	Tetradecanoylphorbol Acetate	52-55	epidermal growth factor	Mus musculus	89-92
22986104-3	2012	TPA induced the expression of critical events of tumorigenesis like ornithine decarboxylase, cyclooxygenase-2, interleukin-6 and pSTAT3 in mouse skin after 5h of application, whereas expression of transglutaminase2 was decreased at this time point.	Tetradecanoylphorbol Acetate	0-3	transglutaminase 2, C polypeptide	Mus musculus	197-214
2769264-3	1989	Exposure to PMA increased the amount of 32P incorporation into several phosphoproteins, including two cytosolic proteins with molecular weights of 30,000 (pI 5.5 and 5.7), an acidic 80,000 molecular weight protein (pI 4.5) present in both the cytosolic and membrane fractions, and two cytoskeletal proteins with molecular weights of 60,000 (pI 5.3) and 55,000 (pI 5.6), identified as vimentin and glial fibrillary acidic protein, respectively.	Tetradecanoylphorbol Acetate	12-15	vimentin	Homo sapiens	384-392
22842666-4	2012	Pterostilbene also reduced TPA-induced phosphorylation of IkappaBalpha and p65 and caused subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	27-30	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	75-78
2529540-4	1989	Loss of MYC seems to be associated with granulocytic differentiation because the time course of its loss was similar to that of appearance of nitroblue tetrazolium-positive cells, mature granulocytes, and its loss was not observed on differentiation of HL-60 cells into macrophages induced by phorbol 12-myristate 13-acetate or teleocidin.	Tetradecanoylphorbol Acetate	293-324	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	8-11
22772753-4	2012	METHODS AND RESULTS: Both phorbol myristate acetate-induced THP-1 and colony-stimulating factor-induced primary monocyte differentiation was associated with an increase in cellular caveolin-1 expression.	Tetradecanoylphorbol Acetate	26-51	caveolin 1, caveolae protein	Mus musculus	181-191
2549060-7	1989	Desensitization to EGF was observed in cells in which protein kinase C had been down-regulated by prolonged treatment with 12-O-tetradecanoylphorbol-13-acetate, implying that EGF receptor desensitization is independent of protein kinase C. The desensitizing effects of EGF on growth factor-induced phosphatidylinositol turnover could be prevented by pretreatment of the cells with the calmodulin antagonist trifluoperazine, suggesting that calmodulin may be involved in the regulation of EGF receptor sensitivity.	Tetradecanoylphorbol Acetate	123-159	epidermal growth factor	Homo sapiens	19-22
22513115-4	2012	In human primary T and Jurkat E6.1 cells, both CD3/CD28 and PMA/Ionomycin induced NF-kappaB activation showed a para-curve correlation with the dosage of small interfering RNA targeting NEMO (siNEMO): the NF-kappaB report gene activity was increased along with ascending doses of transfected siNEMO and reached the highest activity when knockdown about 70% of NEMO, then turned to decline and gradually be blocked once almost thoroughly knockdown of NEMO.	Tetradecanoylphorbol Acetate	60-63	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	186-190
22513115-4	2012	In human primary T and Jurkat E6.1 cells, both CD3/CD28 and PMA/Ionomycin induced NF-kappaB activation showed a para-curve correlation with the dosage of small interfering RNA targeting NEMO (siNEMO): the NF-kappaB report gene activity was increased along with ascending doses of transfected siNEMO and reached the highest activity when knockdown about 70% of NEMO, then turned to decline and gradually be blocked once almost thoroughly knockdown of NEMO.	Tetradecanoylphorbol Acetate	60-63	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	194-198
22513115-4	2012	In human primary T and Jurkat E6.1 cells, both CD3/CD28 and PMA/Ionomycin induced NF-kappaB activation showed a para-curve correlation with the dosage of small interfering RNA targeting NEMO (siNEMO): the NF-kappaB report gene activity was increased along with ascending doses of transfected siNEMO and reached the highest activity when knockdown about 70% of NEMO, then turned to decline and gradually be blocked once almost thoroughly knockdown of NEMO.	Tetradecanoylphorbol Acetate	60-63	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	194-198
2745978-3	1989	In our study we examined the expression of prosolin in human peripheral lymphocytes and investigated the effects of TPA treatment on prosolin phosphorylation and on lymphocyte proliferation.	Tetradecanoylphorbol Acetate	116-119	stathmin 1	Homo sapiens	133-141
22318307-4	2012	In addition, treatment of D-limonene effectively restored the level of reduced glutathione, glutathione peroxidase, glutathione reductase, glutathione S-transferase, catalase and malondialdehyde production in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	209-212	hematopoietic prostaglandin D synthase	Mus musculus	139-164
22562304-4	2012	Intriguingly, Pin1(+/+) mouse embryonic fibroblasts (MEFs) exhibited significantly an increase in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced RSK2 phosphorylation with a marginal Pin1 phosphorylation compared with Pin1(-/-) MEFs.	Tetradecanoylphorbol Acetate	98-134	ribosomal protein S6 kinase polypeptide 3	Mus musculus	149-153
22562304-4	2012	Intriguingly, Pin1(+/+) mouse embryonic fibroblasts (MEFs) exhibited significantly an increase in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced RSK2 phosphorylation with a marginal Pin1 phosphorylation compared with Pin1(-/-) MEFs.	Tetradecanoylphorbol Acetate	136-139	ribosomal protein S6 kinase polypeptide 3	Mus musculus	149-153
2745978-8	1989	TPA treatment of IL-2-dependent PBL at the peak of their growth caused phosphorylation of about two-thirds of preexisting unphosphorylated prosolin within 1 h. This was accompanied by cessation of cell proliferation, as indicated by measurements of TdR incorporation.	Tetradecanoylphorbol Acetate	0-3	stathmin 1	Homo sapiens	139-147
22562304-5	2012	Moreover, TPA-induced Ser(16) Pin1 phosphorylation as well as RSK2 phosphorylation was considerably profound in RSK(+/+) MEFs but not in RSK(-/-) MEFs.	Tetradecanoylphorbol Acetate	10-13	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	30-34
22562304-6	2012	Consequently, knockdown of Pin1 using shRNA-Pin1 suppressed TPA-induced cell transformation in JB6 CI41 cells.	Tetradecanoylphorbol Acetate	60-63	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	27-31
2745978-10	1989	It is suggested that increased phosphorylation of prosolin may be an initiating event in the antiproliferative response to TPA, which would occur only in proliferating lymphocytes expressing prosolin.	Tetradecanoylphorbol Acetate	123-126	stathmin 1	Homo sapiens	50-58
22562304-6	2012	Consequently, knockdown of Pin1 using shRNA-Pin1 suppressed TPA-induced cell transformation in JB6 CI41 cells.	Tetradecanoylphorbol Acetate	60-63	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	44-48
22562304-7	2012	Overall, these results indicate that Pin1 plays a critical role in TPA-induced tumorigenesis plausibly via physical interaction with RSK2 and reciprocal phosphorylation, therefore suggesting a potential therapeutic target for cancer treatment.	Tetradecanoylphorbol Acetate	67-70	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	37-41
2745978-10	1989	It is suggested that increased phosphorylation of prosolin may be an initiating event in the antiproliferative response to TPA, which would occur only in proliferating lymphocytes expressing prosolin.	Tetradecanoylphorbol Acetate	123-126	stathmin 1	Homo sapiens	191-199
22505577-7	2012	VMP1 and pri-miR-21 are induced by common stimuli, such as phorbol-12-myristate-13-acetate (PMA) and androgens, but show differential responses to some stimuli such as epigenetic modifying agents.	Tetradecanoylphorbol Acetate	59-90	vacuole membrane protein 1	Homo sapiens	0-4
2544397-7	1989	Cotreatment of a saturating dose of EGF with phorbol myristate acetate (PMA) or GnRH resulted in additive increases in both tPA enzyme activity and mRNA levels.	Tetradecanoylphorbol Acetate	45-70	plasminogen activator, tissue type	Rattus norvegicus	124-127
2544397-7	1989	Cotreatment of a saturating dose of EGF with phorbol myristate acetate (PMA) or GnRH resulted in additive increases in both tPA enzyme activity and mRNA levels.	Tetradecanoylphorbol Acetate	72-75	plasminogen activator, tissue type	Rattus norvegicus	124-127
22505577-7	2012	VMP1 and pri-miR-21 are induced by common stimuli, such as phorbol-12-myristate-13-acetate (PMA) and androgens, but show differential responses to some stimuli such as epigenetic modifying agents.	Tetradecanoylphorbol Acetate	59-90	microRNA 21	Homo sapiens	13-19
2500450-4	1989	Maximal amounts of PAI-1 mRNA and secretion of PAI-1 polypeptides were observed after 24 hr of TPA treatment and PAI-1 persisted at elevated levels for several days.	Tetradecanoylphorbol Acetate	95-98	serpin family E member 1	Homo sapiens	19-24
22505577-7	2012	VMP1 and pri-miR-21 are induced by common stimuli, such as phorbol-12-myristate-13-acetate (PMA) and androgens, but show differential responses to some stimuli such as epigenetic modifying agents.	Tetradecanoylphorbol Acetate	92-95	vacuole membrane protein 1	Homo sapiens	0-4
22505577-7	2012	VMP1 and pri-miR-21 are induced by common stimuli, such as phorbol-12-myristate-13-acetate (PMA) and androgens, but show differential responses to some stimuli such as epigenetic modifying agents.	Tetradecanoylphorbol Acetate	92-95	microRNA 21	Homo sapiens	13-19
2500450-4	1989	Maximal amounts of PAI-1 mRNA and secretion of PAI-1 polypeptides were observed after 24 hr of TPA treatment and PAI-1 persisted at elevated levels for several days.	Tetradecanoylphorbol Acetate	95-98	serpin family E member 1	Homo sapiens	47-52
22597534-9	2012	Consistent with these results, DHT also suppressed TPA-induced expression of LOX-1.	Tetradecanoylphorbol Acetate	51-54	oxidized low-density lipoprotein receptor 1	Oryctolagus cuniculus	77-82
2504580-4	1989	Truncated c-Jun and JunD proteins containing the C-terminus recognize the same DNA sequences which were defined as the PEA1/AP1 binding sequence or TPA response element (TRE).	Tetradecanoylphorbol Acetate	148-151	jun D proto-oncogene	Mus musculus	20-24
22505246-0	2012	Phosphoinositol 3-kinase, a novel target molecule for the inhibitory             effects of juglone on TPA-induced cell transformation.	Tetradecanoylphorbol Acetate	103-106	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	0-24
2504580-6	1989	Contrary to c-jun and junB transcription, which are strongly stimulated by serum or TPA treatment of quiescent 3T3 cells, junD transcription is not significantly stimulated in these conditions.	Tetradecanoylphorbol Acetate	84-87	jun B proto-oncogene	Mus musculus	22-26
2539973-1	1989	The tumor-promoting phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) increases 25-hydroxyvitamin D3 (25OHD3)-24-hydroxylase and decreases 25OHD3-1-hydroxylase activity in cultured kidney cells, effects similar to those exerted by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and opposite those of PTH, forskolin, and cAMP.	Tetradecanoylphorbol Acetate	34-71	parathyroid hormone	Gallus gallus	301-304
22586143-4	2012	In a phorbol 12-myristate 13-acetate (PMA)-stimulated pituitary adenoma cell line, AtT-20 cells, we found that the cleavage of L1 was correspondingly enhanced with the increased interaction between Src and Shc.	Tetradecanoylphorbol Acetate	5-36	Rous sarcoma oncogene	Mus musculus	198-201
22586143-4	2012	In a phorbol 12-myristate 13-acetate (PMA)-stimulated pituitary adenoma cell line, AtT-20 cells, we found that the cleavage of L1 was correspondingly enhanced with the increased interaction between Src and Shc.	Tetradecanoylphorbol Acetate	38-41	Rous sarcoma oncogene	Mus musculus	198-201
2539973-1	1989	The tumor-promoting phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) increases 25-hydroxyvitamin D3 (25OHD3)-24-hydroxylase and decreases 25OHD3-1-hydroxylase activity in cultured kidney cells, effects similar to those exerted by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and opposite those of PTH, forskolin, and cAMP.	Tetradecanoylphorbol Acetate	73-76	parathyroid hormone	Gallus gallus	301-304
2509679-5	1989	Transfer of these DMBA-initiated, TPA promoted CD-1 mice to chow diet after 13 weeks on the calcium glucarate-supplemented diet, resulted in an increase in the number of skin papillomas within 3 weeks to the level of those seen in control animals maintained exclusively on the chow diet.	Tetradecanoylphorbol Acetate	34-37	CD1 antigen complex	Mus musculus	47-51
22749038-3	2012	Treatment of 17.94 cells with 12-O-Tetradecanoylphorbol 13-acetate caused morphological changes, which led to reduced NCAM and SALL1 expression, but expression of vimentin was maintained, indicating a potential for stromal differentiation.	Tetradecanoylphorbol Acetate	30-66	neural cell adhesion molecule 1	Homo sapiens	118-122
2471189-4	1989	The stimulation of the Na+/H+ exchange mechanism by GM-CSF inhibits further stimulation of this system with either fMet-Leu-Phe or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	131-162	colony stimulating factor 2	Homo sapiens	52-58
22330070-2	2012	T cell activation by T cell receptor (TCR) engagement or its pharmacological mimics, PMA plus ionomycin (PMA/Io), induces immunomodulatory FasL and cyclooxygenase-2 (COX-2) expression.	Tetradecanoylphorbol Acetate	105-108	Fas ligand	Homo sapiens	139-143
22426323-4	2012	A PKC inhibitory study indicated that PMA-induced stimulation of MCT4 expression can be mediated through a novel PKC isoform, especially PKCdelta.	Tetradecanoylphorbol Acetate	38-41	solute carrier family 16 member 3	Homo sapiens	65-69
22311708-1	2012	SOCS-3 gene induction by cAMP-elevating agents or the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), in primary HUVECs was found to require PKCeta- and PKCepsilon-dependent extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	88-119	protein kinase C epsilon	Homo sapiens	72-75
22311708-1	2012	SOCS-3 gene induction by cAMP-elevating agents or the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), in primary HUVECs was found to require PKCeta- and PKCepsilon-dependent extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	88-119	protein kinase C epsilon	Homo sapiens	166-188
22311708-1	2012	SOCS-3 gene induction by cAMP-elevating agents or the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), in primary HUVECs was found to require PKCeta- and PKCepsilon-dependent extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	121-124	protein kinase C epsilon	Homo sapiens	72-75
22311708-1	2012	SOCS-3 gene induction by cAMP-elevating agents or the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), in primary HUVECs was found to require PKCeta- and PKCepsilon-dependent extracellular signal-regulated kinase (ERK) activation.	Tetradecanoylphorbol Acetate	121-124	protein kinase C epsilon	Homo sapiens	166-188
2708347-1	1989	Administration of phorbol 12-myristate 13-acetate (PMA) to rats in vivo resulted in the induction of ornithine decarboxylase activity in the liver which could be blocked by preinjection of indomethacin, a cyclooxygenase inhibitor.	Tetradecanoylphorbol Acetate	18-49	ornithine decarboxylase 1	Rattus norvegicus	101-124
22403260-4	2012	CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment.	Tetradecanoylphorbol Acetate	70-95	neural cell adhesion molecule 1	Homo sapiens	8-12
22403260-4	2012	CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment.	Tetradecanoylphorbol Acetate	97-100	neural cell adhesion molecule 1	Homo sapiens	8-12
22389501-6	2012	Phorbol myristate acetate, a known stimulator of NF-kappaB, increased the levels of GRK5 in myocytes whereas treatment of cells with N-acetyl cysteine, a known inhibitor of NF-kappaB, or with SC 514, an inhibitor of IkappaB kinase 2 decreased GRK5.	Tetradecanoylphorbol Acetate	0-25	inhibitor of kappaB kinase beta	Mus musculus	216-232
22314224-6	2012	By transient transfection analysis with the MMP-1 promoter (-2846 to -29 nt) and AP-1 promoter, MMP-1 and AP-1 promoter activities were induced by phorbol myristate acetate (PMA) but were significantly inhibited by PD98059 (ERK1/2 inhibitor) or SP600125 (JNK inhibitor).	Tetradecanoylphorbol Acetate	147-172	matrix metallopeptidase 1	Homo sapiens	44-49
22314224-6	2012	By transient transfection analysis with the MMP-1 promoter (-2846 to -29 nt) and AP-1 promoter, MMP-1 and AP-1 promoter activities were induced by phorbol myristate acetate (PMA) but were significantly inhibited by PD98059 (ERK1/2 inhibitor) or SP600125 (JNK inhibitor).	Tetradecanoylphorbol Acetate	147-172	matrix metallopeptidase 1	Homo sapiens	96-101
22314224-6	2012	By transient transfection analysis with the MMP-1 promoter (-2846 to -29 nt) and AP-1 promoter, MMP-1 and AP-1 promoter activities were induced by phorbol myristate acetate (PMA) but were significantly inhibited by PD98059 (ERK1/2 inhibitor) or SP600125 (JNK inhibitor).	Tetradecanoylphorbol Acetate	174-177	matrix metallopeptidase 1	Homo sapiens	44-49
22314224-6	2012	By transient transfection analysis with the MMP-1 promoter (-2846 to -29 nt) and AP-1 promoter, MMP-1 and AP-1 promoter activities were induced by phorbol myristate acetate (PMA) but were significantly inhibited by PD98059 (ERK1/2 inhibitor) or SP600125 (JNK inhibitor).	Tetradecanoylphorbol Acetate	174-177	matrix metallopeptidase 1	Homo sapiens	96-101
22298493-1	2012	Triphenylamine (TPA)-based conjugated hyperbranched poly(aryleneethynylene)s (PAEs), hb-P1/2, hb-P1/3, and hb-P1/4, were synthesized with high molecular weights and good solubilities through Sonogashira coupling reactions.	Tetradecanoylphorbol Acetate	16-19	HMG-box transcription factor 1	Homo sapiens	107-114
21895511-8	2012	TNF-alpha treatment promoted NF-kappaB p65 binding to the M-CSF promoter in phorbol 12-myristate 13-acetate (PMA) treated U937 cells chronically infected with HIV-1 (U1 cells), but not in PMA treated uninfected U937 cells, suggesting that the presence of HIV-1 increases the NF-kappaB response.	Tetradecanoylphorbol Acetate	109-112	colony stimulating factor 1	Homo sapiens	58-63
22408753-8	2012	CONCLUSION: This study proved that MIS-TPA has the ability to couple the benefits of less invasive surgical approach.	Tetradecanoylphorbol Acetate	39-42	anti-Mullerian hormone	Homo sapiens	35-38
22975632-3	2012	We previously observed that phorbol 12-myristate 13-acetate (PMA) stimulates phosphorylation of GCMa on serines 328, 378 and 383 through the protein kinase C (PKC)- and mitogen-activated protein kinase kinase (MEK)/extracellular signalregulated kinase (ERK)-dependent pathway, which decreases the protein stability of GCMa.	Tetradecanoylphorbol Acetate	28-59	glial cells missing	Drosophila melanogaster	96-100
22975632-3	2012	We previously observed that phorbol 12-myristate 13-acetate (PMA) stimulates phosphorylation of GCMa on serines 328, 378 and 383 through the protein kinase C (PKC)- and mitogen-activated protein kinase kinase (MEK)/extracellular signalregulated kinase (ERK)-dependent pathway, which decreases the protein stability of GCMa.	Tetradecanoylphorbol Acetate	28-59	Downstream of raf1	Drosophila melanogaster	169-208
22975632-3	2012	We previously observed that phorbol 12-myristate 13-acetate (PMA) stimulates phosphorylation of GCMa on serines 328, 378 and 383 through the protein kinase C (PKC)- and mitogen-activated protein kinase kinase (MEK)/extracellular signalregulated kinase (ERK)-dependent pathway, which decreases the protein stability of GCMa.	Tetradecanoylphorbol Acetate	28-59	Downstream of raf1	Drosophila melanogaster	210-213
21951786-4	2012	We show that recombinant P102 (rP102) binds plasminogen at physiologically relevant concentrations (K(D) ~ 76 nM) increasing the susceptibility of plasmin(ogen) to activation by tissue-specific plasminogen activator (tPA).	Tetradecanoylphorbol Acetate	217-220	COPI coat complex subunit beta 2	Rattus norvegicus	25-29
21951786-4	2012	We show that recombinant P102 (rP102) binds plasminogen at physiologically relevant concentrations (K(D) ~ 76 nM) increasing the susceptibility of plasmin(ogen) to activation by tissue-specific plasminogen activator (tPA).	Tetradecanoylphorbol Acetate	217-220	COPI coat complex subunit beta 2	Rattus norvegicus	31-36
22196048-0	2012	Correlation between EGFR Y1068 tyrosine phosphorylation and AP-1 activation by tumor promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin.	Tetradecanoylphorbol Acetate	94-130	epidermal growth factor receptor	Mus musculus	20-24
22196048-3	2012	In this study, we examined the time course of EGFR phosphorylation and AP-1 activation in mouse epidermis after topical application of a single 10 nmol dose of TPA.	Tetradecanoylphorbol Acetate	160-163	epidermal growth factor receptor	Mus musculus	46-50
22196048-6	2012	These results indicate that the stimulation of AP-1 in mouse epidermis by TPA may be the effect of EGFR activation, but not all tyrosine residues forming its catalytic center are equally involved in this process.	Tetradecanoylphorbol Acetate	74-77	epidermal growth factor receptor	Mus musculus	99-103
22773962-4	2012	We showed that short-term activation of PKC by phobol 12-Myristate 13-Acetate (PMA) inhibited hOAT3 activity through accelerating its internalization from cell surface to intracellular recycling endosomes.	Tetradecanoylphorbol Acetate	79-82	solute carrier family 22 member 8	Homo sapiens	94-99
21984036-11	2012	Heparin can decrease the level of Duox1, ROS production and block the PMA-induced activation of EGFR, thus inhibiting the overexpression of mucin MUC5AC in a dose-dependent manner.	Tetradecanoylphorbol Acetate	70-73	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	146-152
22911849-9	2012	Over-expression of the dominant negative p53 mutant DeltaTAp53, which inhibits p53 activity, prevented the TPA-induced K14 down-regulation in C9 cells.	Tetradecanoylphorbol Acetate	107-110	keratin 14	Homo sapiens	119-122
22911849-11	2012	Finally, we found that TPA induces the phosphorylation of p53 at residue 378, which enhances the affinity of p53 to bind to Sp1 and repress K14 expression.	Tetradecanoylphorbol Acetate	23-26	keratin 14	Homo sapiens	140-143
21976662-6	2011	However, unlike fibrin, dsDNA/oligonucleotides moderately affect the reaction between plasmin and alpha(2)-antiplasmin and accelerate the inactivation of tPA and two chain uPA by plasminogen activator inhibitor-1 (PAI-1), which is potentiated by vitronectin.	Tetradecanoylphorbol Acetate	154-157	serpin family E member 1	Homo sapiens	179-212
22001392-5	2011	We first demonstrate that AP-1 activation by 12-O-tetradecanoylphorbol-13-acetate induces PTPROt expression with concurrent recruitment of c-fos and c-jun to its promoter.	Tetradecanoylphorbol Acetate	45-81	FBJ osteosarcoma oncogene	Mus musculus	139-144
22160590-5	2011	Treatment with TPA modified the activity of phosphoPKCalpha and caused an increase of the Snail family members Snail, Slug and Smad-interacting protein 1 and a decrease of E-cadherin.	Tetradecanoylphorbol Acetate	15-18	zinc finger E-box binding homeobox 2	Homo sapiens	127-153
22346774-0	2011	NDRG2 Promotes GATA-1 Expression through Regulation of the JAK2/STAT Pathway in PMA-stimulated U937 Cells.	Tetradecanoylphorbol Acetate	80-83	NDRG family member 2	Homo sapiens	0-5
21400615-4	2011	Western blot analysis revealed that 5"-NIO inhibited activities of Raf-1 (S338), MEK1/2, ERK1/2, JNK, and c-Jun induced by EGF or TPA, respectively, whereas it did not affect autophosphorylation of epidermal growth factor receptor (EGFR) induced by EGF or TPA.	Tetradecanoylphorbol Acetate	130-133	epidermal growth factor receptor	Mus musculus	198-230
21400615-4	2011	Western blot analysis revealed that 5"-NIO inhibited activities of Raf-1 (S338), MEK1/2, ERK1/2, JNK, and c-Jun induced by EGF or TPA, respectively, whereas it did not affect autophosphorylation of epidermal growth factor receptor (EGFR) induced by EGF or TPA.	Tetradecanoylphorbol Acetate	130-133	epidermal growth factor receptor	Mus musculus	232-236
21400615-4	2011	Western blot analysis revealed that 5"-NIO inhibited activities of Raf-1 (S338), MEK1/2, ERK1/2, JNK, and c-Jun induced by EGF or TPA, respectively, whereas it did not affect autophosphorylation of epidermal growth factor receptor (EGFR) induced by EGF or TPA.	Tetradecanoylphorbol Acetate	130-133	epidermal growth factor	Mus musculus	232-235
21400615-5	2011	In addition, 5"-NIO exerted strong inhibitory effects on the EGF- or TPA-induced c-fos or c-jun transcriptional activity, and thereby inhibited the associated activator protein-1 (AP-1) transactivation activity induced by EGF or TPA.	Tetradecanoylphorbol Acetate	69-72	FBJ osteosarcoma oncogene	Mus musculus	81-86
21400615-5	2011	In addition, 5"-NIO exerted strong inhibitory effects on the EGF- or TPA-induced c-fos or c-jun transcriptional activity, and thereby inhibited the associated activator protein-1 (AP-1) transactivation activity induced by EGF or TPA.	Tetradecanoylphorbol Acetate	69-72	epidermal growth factor	Mus musculus	222-225
21400615-5	2011	In addition, 5"-NIO exerted strong inhibitory effects on the EGF- or TPA-induced c-fos or c-jun transcriptional activity, and thereby inhibited the associated activator protein-1 (AP-1) transactivation activity induced by EGF or TPA.	Tetradecanoylphorbol Acetate	229-232	epidermal growth factor	Mus musculus	61-64
21975931-4	2011	Gstp(-/-)/Tg.AC mice exposed to the proinflammatory phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) exhibited higher tumor incidence and multiplicity with a significant thickening of skin after treatment, illustrating hyperproliferative growth.	Tetradecanoylphorbol Acetate	66-102	glutathione S-transferase pi 1	Homo sapiens	0-4
21975931-4	2011	Gstp(-/-)/Tg.AC mice exposed to the proinflammatory phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) exhibited higher tumor incidence and multiplicity with a significant thickening of skin after treatment, illustrating hyperproliferative growth.	Tetradecanoylphorbol Acetate	104-107	glutathione S-transferase pi 1	Homo sapiens	0-4
21975931-7	2011	Within 4 weeks of TPA treatment, Gstp(-/-)/Tg.AC mice displayed altered lipid/sterol metabolism and Wnt signaling along with aberrant processes of cytoskeletal control and epidermal morphogenesis at both early and late times.	Tetradecanoylphorbol Acetate	18-21	glutathione S-transferase pi 1	Homo sapiens	33-37
22553356-7	2012	In the presence of hIGF-II, large complexes of m660 were formed that bound to FcgammaRII-expressing BJAB cells much more efficiently than the monospecific antibody-hIGF-II complexes and were presumably phagocytosed by phorbol 12-myristate 13-acetate-stimulated macrophage-like U937 cells.	Tetradecanoylphorbol Acetate	218-249	insulin like growth factor 2	Homo sapiens	19-26
22747686-1	2012	BACKGROUND: Plasminogen activator inhibitor type 1 (PAI-1) is the primary inhibitor of urokinase type plasminogen activators (uPA) and tissue type plasminogen activators (tPA), which mediate fibrinolysis.	Tetradecanoylphorbol Acetate	171-174	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	12-50
22747686-1	2012	BACKGROUND: Plasminogen activator inhibitor type 1 (PAI-1) is the primary inhibitor of urokinase type plasminogen activators (uPA) and tissue type plasminogen activators (tPA), which mediate fibrinolysis.	Tetradecanoylphorbol Acetate	171-174	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	52-57
22555148-3	2012	The novel hybrid nanoparticles (CdS/L) were then obtained using the L as surface capped agent, which aggregate into large spheres, exhibiting novel luminescent properties, strong two photon absorption (TPA) and obvious prolonged fluorescence lifetime, which differ from those of the pure CdS nanocrystals and free L.	Tetradecanoylphorbol Acetate	202-205	CDP-diacylglycerol synthase 1	Homo sapiens	32-35
22160839-4	2012	Th1 and Th2 cells, levels of INF-gamma, IL-2, IL-4 and the activities of T-bet and GATA3 were significantly increased after incubation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	140-143	T-box transcription factor 21	Homo sapiens	73-78
22160839-5	2012	However, the number of Th1 cells, Th1/ Th2, the levels of INF-gamma and INF-gamma/IL-4, and the activities and protein levels of T-bet and GATA3 were decreased after incubation with PMA and ionomycin in the presence of morphine.	Tetradecanoylphorbol Acetate	182-185	T-box transcription factor 21	Homo sapiens	129-134
22168364-6	2012	KEY RESULTS: Stimulation of PKC using phorbol 12-myristate-13-acetate (PMA) activated the hK(2P) 18.1 current by 3.1-fold in a concentration-dependent fashion.	Tetradecanoylphorbol Acetate	38-69	keratin 76	Homo sapiens	90-95
22168364-6	2012	KEY RESULTS: Stimulation of PKC using phorbol 12-myristate-13-acetate (PMA) activated the hK(2P) 18.1 current by 3.1-fold in a concentration-dependent fashion.	Tetradecanoylphorbol Acetate	71-74	keratin 76	Homo sapiens	90-95
22357272-2	2012	The BZLF1 promoter (Zp) normally exhibits only low basal activity but is activated in response to chemical or biological inducers, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), calcium ionophores, or histone deacetylase (HDAC) inhibitors.	Tetradecanoylphorbol Acetate	139-175	protein Zta	Human gammaherpesvirus 4	4-9
22357272-2	2012	The BZLF1 promoter (Zp) normally exhibits only low basal activity but is activated in response to chemical or biological inducers, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), calcium ionophores, or histone deacetylase (HDAC) inhibitors.	Tetradecanoylphorbol Acetate	177-180	protein Zta	Human gammaherpesvirus 4	4-9
21538579-2	2012	Studies from our laboratory using the classical mouse skin carcinogenesis model, with 7,12-dimethyl-benz[a]anthracene (DMBA) for initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA) for promotion, showed that expression of CTSL is increased in papillomas and squamous cell carcinomas (SCC).	Tetradecanoylphorbol Acetate	144-180	cathepsin L	Mus musculus	228-232
21538579-6	2012	Reduced epidermal cell proliferation in Ctsl-deficient nkt/nkt mice after TPA treatment suggested that they are not more sensitive than wild-type mice to TPA promotion.	Tetradecanoylphorbol Acetate	74-77	cathepsin L	Mus musculus	40-44
21895511-8	2012	TNF-alpha treatment promoted NF-kappaB p65 binding to the M-CSF promoter in phorbol 12-myristate 13-acetate (PMA) treated U937 cells chronically infected with HIV-1 (U1 cells), but not in PMA treated uninfected U937 cells, suggesting that the presence of HIV-1 increases the NF-kappaB response.	Tetradecanoylphorbol Acetate	76-107	colony stimulating factor 1	Homo sapiens	58-63
22200849-0	2012	Activation of MAP kinase family members triggered by TPA or ionomycin occurs via the protein phosphatase 4 pathway in Jurkat leukemia T cells.	Tetradecanoylphorbol Acetate	53-56	protein phosphatase 4 catalytic subunit	Homo sapiens	85-106
22200849-3	2012	In this study, we investigated the effect of overexpression of PP4 on the expression of members of the MAP kinase family in Jurkat leukemia T cells, which had previously been stimulated with UV, 12-O-tetradecanoylphorbol-13-acetate (TPA), ionomycin and okadaic acid.	Tetradecanoylphorbol Acetate	233-236	protein phosphatase 4 catalytic subunit	Homo sapiens	63-66
22200849-5	2012	However, TPA, UV or ionomycin treatment strongly increased the activity of PP4.	Tetradecanoylphorbol Acetate	9-12	protein phosphatase 4 catalytic subunit	Homo sapiens	75-78
22052014-8	2012	In addition, blockade of PKCdelta by rottlerin, a PKCdelta-specific inhibitor, and ERK1/2 by U0126, a MEK-ERK inhibitor, abrogated PMA-induced Egr-1 expression.	Tetradecanoylphorbol Acetate	131-134	early growth response 1	Homo sapiens	143-148
22052014-10	2012	Consistent with these data, PMA-induced Egr-1 interaction with the NHE2 promoter region was prevented in nuclear extracts from U0126-pretreated cells.	Tetradecanoylphorbol Acetate	28-31	early growth response 1	Homo sapiens	40-45
22020547-0	2012	TPA-induced p21 expression augments G2/M arrest through a p53-independent             mechanism in human breast cancer cells.	Tetradecanoylphorbol Acetate	0-3	H3 histone pseudogene 16	Homo sapiens	12-15
22020547-4	2012	Our results showed that TPA increased the level of p21 expression             in MCF-7 cells with wild-type p53 and MDA-MB-231 cells with mutant p53 in a dose-dependent             manner.	Tetradecanoylphorbol Acetate	24-27	H3 histone pseudogene 16	Homo sapiens	51-54
22020547-6	2012	We next examined the regulatory mechanism of TPA             on p21 and p53 expression.	Tetradecanoylphorbol Acetate	45-48	H3 histone pseudogene 16	Homo sapiens	64-67
22020547-7	2012	Our results showed that the TPA-induced up-regulation             of p21 and down-regulation of p53 was reversed by UO126 (a MEK1/2 inhibitor),             but not by SP600125 (a JNK inhibitor) or SB203580 (a p38 inhibitor), although             TPA increased the phosphorylation of ERK and JNK in MCF-7 cells.	Tetradecanoylphorbol Acetate	28-31	H3 histone pseudogene 16	Homo sapiens	69-72
22020547-7	2012	Our results showed that the TPA-induced up-regulation             of p21 and down-regulation of p53 was reversed by UO126 (a MEK1/2 inhibitor),             but not by SP600125 (a JNK inhibitor) or SB203580 (a p38 inhibitor), although             TPA increased the phosphorylation of ERK and JNK in MCF-7 cells.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase kinase 1	Homo sapiens	125-131
2708347-1	1989	Administration of phorbol 12-myristate 13-acetate (PMA) to rats in vivo resulted in the induction of ornithine decarboxylase activity in the liver which could be blocked by preinjection of indomethacin, a cyclooxygenase inhibitor.	Tetradecanoylphorbol Acetate	51-54	ornithine decarboxylase 1	Rattus norvegicus	101-124
22119642-9	2012	Conversely, treatment of cerebellar lysates with phorbol 12-myristate-13-acetate (PMA), a PKC activator, increased serine phosphorylation of GABA(A)gamma(2).	Tetradecanoylphorbol Acetate	49-80	protein kinase C, gamma	Mus musculus	90-93
2540997-1	1989	We have examined the effects of a biologically active tumor promoting phorbol ester (phorbol 12-myristate, 13-acetate (PMA] which activates protein kinase C (PKC) on melanotropin receptor function and cell growth in the M2R mouse melanoma cell clone.	Tetradecanoylphorbol Acetate	119-122	melanocortin 1 receptor	Homo sapiens	166-187
22119642-9	2012	Conversely, treatment of cerebellar lysates with phorbol 12-myristate-13-acetate (PMA), a PKC activator, increased serine phosphorylation of GABA(A)gamma(2).	Tetradecanoylphorbol Acetate	82-85	protein kinase C, gamma	Mus musculus	90-93
22975632-3	2012	We previously observed that phorbol 12-myristate 13-acetate (PMA) stimulates phosphorylation of GCMa on serines 328, 378 and 383 through the protein kinase C (PKC)- and mitogen-activated protein kinase kinase (MEK)/extracellular signalregulated kinase (ERK)-dependent pathway, which decreases the protein stability of GCMa.	Tetradecanoylphorbol Acetate	28-59	glial cells missing	Drosophila melanogaster	318-322
22975632-3	2012	We previously observed that phorbol 12-myristate 13-acetate (PMA) stimulates phosphorylation of GCMa on serines 328, 378 and 383 through the protein kinase C (PKC)- and mitogen-activated protein kinase kinase (MEK)/extracellular signalregulated kinase (ERK)-dependent pathway, which decreases the protein stability of GCMa.	Tetradecanoylphorbol Acetate	61-64	glial cells missing	Drosophila melanogaster	96-100
22975632-3	2012	We previously observed that phorbol 12-myristate 13-acetate (PMA) stimulates phosphorylation of GCMa on serines 328, 378 and 383 through the protein kinase C (PKC)- and mitogen-activated protein kinase kinase (MEK)/extracellular signalregulated kinase (ERK)-dependent pathway, which decreases the protein stability of GCMa.	Tetradecanoylphorbol Acetate	61-64	Downstream of raf1	Drosophila melanogaster	169-208
2665635-0	1989	Human immunodeficiency virus long terminal repeat responds to transformation by the mutant T24 H-ras1 oncogene and it contains multiple AP-1 binding TPA-inducible consensus sequence elements.	Tetradecanoylphorbol Acetate	149-152	HRas proto-oncogene, GTPase	Homo sapiens	95-101
22975632-3	2012	We previously observed that phorbol 12-myristate 13-acetate (PMA) stimulates phosphorylation of GCMa on serines 328, 378 and 383 through the protein kinase C (PKC)- and mitogen-activated protein kinase kinase (MEK)/extracellular signalregulated kinase (ERK)-dependent pathway, which decreases the protein stability of GCMa.	Tetradecanoylphorbol Acetate	61-64	Downstream of raf1	Drosophila melanogaster	210-213
22975632-3	2012	We previously observed that phorbol 12-myristate 13-acetate (PMA) stimulates phosphorylation of GCMa on serines 328, 378 and 383 through the protein kinase C (PKC)- and mitogen-activated protein kinase kinase (MEK)/extracellular signalregulated kinase (ERK)-dependent pathway, which decreases the protein stability of GCMa.	Tetradecanoylphorbol Acetate	61-64	glial cells missing	Drosophila melanogaster	318-322
22975632-6	2012	Our data indicate that the PMA-induced PKC- and MEK/ERKdependent pathway enhances the degradation as well as the transcriptional activity of GCMa.	Tetradecanoylphorbol Acetate	27-30	Protein C kinase 53E	Drosophila melanogaster	39-43
22975632-6	2012	Our data indicate that the PMA-induced PKC- and MEK/ERKdependent pathway enhances the degradation as well as the transcriptional activity of GCMa.	Tetradecanoylphorbol Acetate	27-30	Downstream of raf1	Drosophila melanogaster	48-51
22975632-6	2012	Our data indicate that the PMA-induced PKC- and MEK/ERKdependent pathway enhances the degradation as well as the transcriptional activity of GCMa.	Tetradecanoylphorbol Acetate	27-30	glial cells missing	Drosophila melanogaster	141-145
2665635-6	1989	Since H-ras1 fos and jun/AP-1 respond to TPA and T24 H-ras1 is known to induce both fos and jun/AP-1 nuclear transcriptional factors, it is possible that the latter genes play a role in HIV-1 transcription.	Tetradecanoylphorbol Acetate	41-44	HRas proto-oncogene, GTPase	Homo sapiens	6-12
2784064-5	1989	In the presence of the phorbol ester TPA, leukemic blasts from two cases differentiated along the B precursor pathway to the [CD2-CD10+CD19+CD20+C mu+slg-] pre-B cell stage.	Tetradecanoylphorbol Acetate	37-40	CD2 molecule	Homo sapiens	126-129
21930201-13	2012	However, cytochalasin treatment of PMA-treated cells that had developed stress fibers increased F4 and decreased F5.	Tetradecanoylphorbol Acetate	35-38	coagulation factor V	Homo sapiens	113-115
2646027-0	1989	L-fucose blocks MIF/MAF priming of rabbit alveolar macrophages for a PMA-induced oxidative response.	Tetradecanoylphorbol Acetate	69-72	macrophage migration inhibitory factor	Oryctolagus cuniculus	16-19
22879735-4	2012	Immunocytochemistry was performed to visualize EC and PC in coculture, and to evaluate phorbol 12-myristate-13-acetate (PMA)-induced HuR translocation.	Tetradecanoylphorbol Acetate	87-118	ELAV like RNA binding protein 1	Homo sapiens	133-136
22879735-4	2012	Immunocytochemistry was performed to visualize EC and PC in coculture, and to evaluate phorbol 12-myristate-13-acetate (PMA)-induced HuR translocation.	Tetradecanoylphorbol Acetate	120-123	ELAV like RNA binding protein 1	Homo sapiens	133-136
2471685-0	1989	The immunosuppressant FK-506, like cyclosporins and didemnin B, inhibits calmodulin-dependent phosphorylation of the elongation factor 2 in vitro and biological effects of the phorbol ester TPA on mouse skin in vivo.	Tetradecanoylphorbol Acetate	190-193	eukaryotic translation elongation factor 2	Mus musculus	117-136
2471685-1	1989	Similar to previous observations with cyclosporins and didemnin B, the novel immunosuppressant FK-506 inhibits the Ca2+/calmodulin-dependent phosphorylation of the eukaryotic elongation factor 2 of protein synthesis in vitro and biological effects of the phorbol ester TPA on mouse skin in vivo.	Tetradecanoylphorbol Acetate	269-272	eukaryotic translation elongation factor 2	Mus musculus	175-194
2914963-3	1989	Phorbol 12-myristate 13-acetate (PMA) can activate protein kinase C and induce ornithine decarboxylase in PC12 cells with kinetics which are similar to those of NGF induction, but only to levels about 10-fold lower.	Tetradecanoylphorbol Acetate	0-31	ornithine decarboxylase 1	Rattus norvegicus	79-102
2914963-3	1989	Phorbol 12-myristate 13-acetate (PMA) can activate protein kinase C and induce ornithine decarboxylase in PC12 cells with kinetics which are similar to those of NGF induction, but only to levels about 10-fold lower.	Tetradecanoylphorbol Acetate	33-36	ornithine decarboxylase 1	Rattus norvegicus	79-102
2914906-0	1989	In situ phosphorylation of human platelet myosin heavy and light chains by protein kinase C. Treatment of human platelets with 162 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in phosphorylation of a number of peptides, including myosin heavy chain and the 20-kDa myosin light chain.	Tetradecanoylphorbol Acetate	134-170	myosin heavy chain 14	Homo sapiens	42-48
2914906-0	1989	In situ phosphorylation of human platelet myosin heavy and light chains by protein kinase C. Treatment of human platelets with 162 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in phosphorylation of a number of peptides, including myosin heavy chain and the 20-kDa myosin light chain.	Tetradecanoylphorbol Acetate	134-170	myosin heavy chain 14	Homo sapiens	240-246
2914906-0	1989	In situ phosphorylation of human platelet myosin heavy and light chains by protein kinase C. Treatment of human platelets with 162 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in phosphorylation of a number of peptides, including myosin heavy chain and the 20-kDa myosin light chain.	Tetradecanoylphorbol Acetate	172-175	myosin heavy chain 14	Homo sapiens	42-48
2914906-0	1989	In situ phosphorylation of human platelet myosin heavy and light chains by protein kinase C. Treatment of human platelets with 162 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in phosphorylation of a number of peptides, including myosin heavy chain and the 20-kDa myosin light chain.	Tetradecanoylphorbol Acetate	172-175	myosin heavy chain 14	Homo sapiens	240-246
2914906-8	1989	These results suggest that TPA mediates phosphorylation of both myosin light and heavy chains in intact platelets by activation of protein kinase C.	Tetradecanoylphorbol Acetate	27-30	myosin heavy chain 14	Homo sapiens	64-70
2495823-1	1989	Using sheep thyroid cells in culture, we have studied the effects of thyroid stimulating hormone (TSH), epidermal growth factor (EGF) and the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) on the activity and expression of both thyroglobulin (Tg) and thyroid peroxidase (TPO) and on the ability of cells to trap and organify iodide.	Tetradecanoylphorbol Acetate	158-194	thyroglobulin	Ovis aries	240-253
2495823-8	1989	TPA and EGF (1 nM) reduced the amount of newly synthesized Tg in TSH-stimulated cells by 50% but the absolute amount of Tg within the cells was not markedly inhibited at these early times.	Tetradecanoylphorbol Acetate	0-3	thyroglobulin	Ovis aries	59-61
2783391-3	1989	In this report we describe a human astrocytoma cell line (T24) which produces IL-1 constitutively and upon induction with phorbol myristate acetate in vitro.	Tetradecanoylphorbol Acetate	122-147	interleukin 1 alpha	Homo sapiens	78-82
2492471-1	1989	Treatment of EL-4 lymphoma cells with tetradecanoylphorbol-acetate (TPA), a well-known activator of protein kinase C, induces the production of the T cell growth factor interleukin-2 (IL-2) and the expression of IL-2-specific mRNA within 4-8 h. This system is an ideal model for studies on the induction of a differentiated function in a homogeneous lymphoid cell population by a defined signal.	Tetradecanoylphorbol Acetate	38-66	interleukin 2	Mus musculus	169-182
2492471-1	1989	Treatment of EL-4 lymphoma cells with tetradecanoylphorbol-acetate (TPA), a well-known activator of protein kinase C, induces the production of the T cell growth factor interleukin-2 (IL-2) and the expression of IL-2-specific mRNA within 4-8 h. This system is an ideal model for studies on the induction of a differentiated function in a homogeneous lymphoid cell population by a defined signal.	Tetradecanoylphorbol Acetate	38-66	interleukin 2	Mus musculus	184-188
2492471-1	1989	Treatment of EL-4 lymphoma cells with tetradecanoylphorbol-acetate (TPA), a well-known activator of protein kinase C, induces the production of the T cell growth factor interleukin-2 (IL-2) and the expression of IL-2-specific mRNA within 4-8 h. This system is an ideal model for studies on the induction of a differentiated function in a homogeneous lymphoid cell population by a defined signal.	Tetradecanoylphorbol Acetate	38-66	interleukin 2	Mus musculus	212-216
2492471-1	1989	Treatment of EL-4 lymphoma cells with tetradecanoylphorbol-acetate (TPA), a well-known activator of protein kinase C, induces the production of the T cell growth factor interleukin-2 (IL-2) and the expression of IL-2-specific mRNA within 4-8 h. This system is an ideal model for studies on the induction of a differentiated function in a homogeneous lymphoid cell population by a defined signal.	Tetradecanoylphorbol Acetate	68-71	interleukin 2	Mus musculus	169-182
2492471-1	1989	Treatment of EL-4 lymphoma cells with tetradecanoylphorbol-acetate (TPA), a well-known activator of protein kinase C, induces the production of the T cell growth factor interleukin-2 (IL-2) and the expression of IL-2-specific mRNA within 4-8 h. This system is an ideal model for studies on the induction of a differentiated function in a homogeneous lymphoid cell population by a defined signal.	Tetradecanoylphorbol Acetate	68-71	interleukin 2	Mus musculus	184-188
2492471-1	1989	Treatment of EL-4 lymphoma cells with tetradecanoylphorbol-acetate (TPA), a well-known activator of protein kinase C, induces the production of the T cell growth factor interleukin-2 (IL-2) and the expression of IL-2-specific mRNA within 4-8 h. This system is an ideal model for studies on the induction of a differentiated function in a homogeneous lymphoid cell population by a defined signal.	Tetradecanoylphorbol Acetate	68-71	interleukin 2	Mus musculus	212-216
2492471-4	1989	Putrescine has rather a counter-regulatory effect as concluded from the observation that the TPA-induced TCGF production and IL-2-specific mRNA expression are augmented (superinduced) by the ODC inhibitor D,L-alpha-difluoromethylornithine (DFMO) and again suppressed after the administration of putrescine or polyamines to DFMO-treated cultures.	Tetradecanoylphorbol Acetate	93-96	interleukin 2	Mus musculus	105-109
2492471-4	1989	Putrescine has rather a counter-regulatory effect as concluded from the observation that the TPA-induced TCGF production and IL-2-specific mRNA expression are augmented (superinduced) by the ODC inhibitor D,L-alpha-difluoromethylornithine (DFMO) and again suppressed after the administration of putrescine or polyamines to DFMO-treated cultures.	Tetradecanoylphorbol Acetate	93-96	interleukin 2	Mus musculus	125-129
2542017-2	1989	This enhancer contains most, if not all of the sequence elements necessary for the T cell specific induction of the Il-2 gene by the phorbol ester TPA and the plant lectin Concanavalin A.	Tetradecanoylphorbol Acetate	147-150	interleukin 2	Mus musculus	116-120
2537886-1	1989	Feline peripheral blood lymphocytes (PBLs) produce interleukin-2 (IL-2) when stimulated with concanavalin A (Con A) or the combination of the Ca2+ ionophore A23187 (A2) plus the phorbol ester phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	192-223	interleukin 2	Felis catus	51-64
2537886-1	1989	Feline peripheral blood lymphocytes (PBLs) produce interleukin-2 (IL-2) when stimulated with concanavalin A (Con A) or the combination of the Ca2+ ionophore A23187 (A2) plus the phorbol ester phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	192-223	interleukin 2	Felis catus	66-70
2537886-1	1989	Feline peripheral blood lymphocytes (PBLs) produce interleukin-2 (IL-2) when stimulated with concanavalin A (Con A) or the combination of the Ca2+ ionophore A23187 (A2) plus the phorbol ester phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	225-228	interleukin 2	Felis catus	51-64
2537886-1	1989	Feline peripheral blood lymphocytes (PBLs) produce interleukin-2 (IL-2) when stimulated with concanavalin A (Con A) or the combination of the Ca2+ ionophore A23187 (A2) plus the phorbol ester phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	225-228	interleukin 2	Felis catus	66-70
2715723-7	1989	The activity of CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase (ST1), a key enzyme for membrane gangliosides synthesis, in HL-60 cells was also influenced by the exposure to TPA, GM3, DMSO, GM1, or sulfatides.	Tetradecanoylphorbol Acetate	190-193	syndecan binding protein	Homo sapiens	80-83
2715723-8	1989	The inducers of differentiation, TPA and DMSO, caused an increase in ST1 activity, whereas GM3, which also induced cellular differentiation, inhibited ST1 activity, perhaps through the action of end-product inhibition.	Tetradecanoylphorbol Acetate	33-36	syndecan binding protein	Homo sapiens	69-72
2919164-1	1989	Transcription of the low density lipoprotein receptor (LDL-R) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase genes was rapidly and transiently induced (8.5- and 2.3-fold, respectively) early during phorbol 12-myristate 13-acetate (PMA)-induced macrophage differentiation of the human monocytic leukemia cell line THP-1.	Tetradecanoylphorbol Acetate	213-244	low density lipoprotein receptor	Homo sapiens	21-53
2919164-1	1989	Transcription of the low density lipoprotein receptor (LDL-R) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase genes was rapidly and transiently induced (8.5- and 2.3-fold, respectively) early during phorbol 12-myristate 13-acetate (PMA)-induced macrophage differentiation of the human monocytic leukemia cell line THP-1.	Tetradecanoylphorbol Acetate	213-244	low density lipoprotein receptor	Homo sapiens	55-60
2919164-1	1989	Transcription of the low density lipoprotein receptor (LDL-R) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase genes was rapidly and transiently induced (8.5- and 2.3-fold, respectively) early during phorbol 12-myristate 13-acetate (PMA)-induced macrophage differentiation of the human monocytic leukemia cell line THP-1.	Tetradecanoylphorbol Acetate	213-244	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	66-123
2919164-1	1989	Transcription of the low density lipoprotein receptor (LDL-R) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase genes was rapidly and transiently induced (8.5- and 2.3-fold, respectively) early during phorbol 12-myristate 13-acetate (PMA)-induced macrophage differentiation of the human monocytic leukemia cell line THP-1.	Tetradecanoylphorbol Acetate	246-249	low density lipoprotein receptor	Homo sapiens	21-53
2919164-1	1989	Transcription of the low density lipoprotein receptor (LDL-R) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase genes was rapidly and transiently induced (8.5- and 2.3-fold, respectively) early during phorbol 12-myristate 13-acetate (PMA)-induced macrophage differentiation of the human monocytic leukemia cell line THP-1.	Tetradecanoylphorbol Acetate	246-249	low density lipoprotein receptor	Homo sapiens	55-60
2919164-1	1989	Transcription of the low density lipoprotein receptor (LDL-R) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase genes was rapidly and transiently induced (8.5- and 2.3-fold, respectively) early during phorbol 12-myristate 13-acetate (PMA)-induced macrophage differentiation of the human monocytic leukemia cell line THP-1.	Tetradecanoylphorbol Acetate	246-249	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	66-123
2492047-6	1989	Ag-mediated activation of cytolysis, lymphokine production, and exocytosis could be mimicked by mAb against the TCR/CD3 complex, or by stimulation with the combination of PMA + calcium ionophore, which appear to bypass the TCR (neither PMA nor calcium ionophore alone induced these functions efficiently in our CD8+ CTL clones).	Tetradecanoylphorbol Acetate	171-174	T cell receptor alpha variable 6-3	Mus musculus	112-115
2492047-6	1989	Ag-mediated activation of cytolysis, lymphokine production, and exocytosis could be mimicked by mAb against the TCR/CD3 complex, or by stimulation with the combination of PMA + calcium ionophore, which appear to bypass the TCR (neither PMA nor calcium ionophore alone induced these functions efficiently in our CD8+ CTL clones).	Tetradecanoylphorbol Acetate	171-174	T cell receptor alpha variable 6-3	Mus musculus	223-226
2624919-4	1989	Incubation of the three melanoma cell lines with interferon beta, TPA or their combination resulted in a differential modulation of the expression of membrane-bound high-molecular-mass melanoma-associated antigen, 115-kDa MAA, 100-kDa MAA, intercellular adhesion molecule 1, HLA class I antigens and gene products of the HLA-D region.	Tetradecanoylphorbol Acetate	66-69	MAA	Homo sapiens	222-225
2624919-4	1989	Incubation of the three melanoma cell lines with interferon beta, TPA or their combination resulted in a differential modulation of the expression of membrane-bound high-molecular-mass melanoma-associated antigen, 115-kDa MAA, 100-kDa MAA, intercellular adhesion molecule 1, HLA class I antigens and gene products of the HLA-D region.	Tetradecanoylphorbol Acetate	66-69	MAA	Homo sapiens	235-238
2707879-6	1989	Cells pretreated with PAF responded poorly to a second stimulation with phorbol myristate acetate whereas a secondary response was seen with cells pretreated with interferon-gamma.	Tetradecanoylphorbol Acetate	72-97	PCNA clamp associated factor	Homo sapiens	22-25
2527510-4	1989	The steady-state level of IL-1 alpha mRNA in these cells could be drastically increased by a short culture of the cells with the protein synthesis inhibitor cycloheximide or with PMA.	Tetradecanoylphorbol Acetate	179-182	interleukin 1 alpha	Homo sapiens	26-36
2542734-7	1989	Taken collectively, these experiments support the notion that IL1 does not trigger IL2 gene activation per se, but amplifies the preactivated lymphokine genes initiated by PMA and ionomycin, whereas IL1 can activate the IL2 receptor gene without any other known signal requirements.	Tetradecanoylphorbol Acetate	172-175	interleukin 1 alpha	Homo sapiens	62-65
2464751-3	1989	Spectrophotometric analyses of 560 corticotropes from fractions enriched to 90% by counterflow centrifugation showed a 30% increase in the average area of the dark blue label for biotinylated CRH after a 1-h exposure to 10 nM AVP or after activation of protein kinase-C [by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or L calcium channels (by Bay K 8644).	Tetradecanoylphorbol Acetate	274-311	corticotropin releasing hormone	Homo sapiens	192-195
2464751-3	1989	Spectrophotometric analyses of 560 corticotropes from fractions enriched to 90% by counterflow centrifugation showed a 30% increase in the average area of the dark blue label for biotinylated CRH after a 1-h exposure to 10 nM AVP or after activation of protein kinase-C [by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or L calcium channels (by Bay K 8644).	Tetradecanoylphorbol Acetate	313-316	corticotropin releasing hormone	Homo sapiens	192-195
2464751-7	1989	When mixed pituitary cell populations were analyzed for percentages of labeled cells, exposure to Bay K 8644, TPA, angiotensin II, or AVP resulted in 30-40% increases in the percentage of CRH-bound cells.	Tetradecanoylphorbol Acetate	110-113	corticotropin releasing hormone	Homo sapiens	188-191
2538715-7	1989	The expression of each of these genes, including d-2 (NGF I-A), was also increased by fibroblast growth factor, epidermal growth factor (EGF), phorbol myristate acetate, and in some cases insulin, showing that the regulation of these genes is not unique to NGF.	Tetradecanoylphorbol Acetate	143-168	solute carrier family 3 member 1	Rattus norvegicus	49-52
2467914-3	1988	Both interferons and TPA down-regulate expression of the c-myc oncogene in these cells.	Tetradecanoylphorbol Acetate	21-24	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	57-62
2467914-7	1988	This agent induces a higher level of c-myc mRNA in the cells and stimulates the incorporation of [3H]thymidine into DNA; although these effects are partially counteracted by interferon or TPA treatment, the elevated expression of the c-myc gene may be sufficient to prevent terminal differentiation and allow cell proliferation to continue.	Tetradecanoylphorbol Acetate	188-191	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	37-42
21674298-8	2011	The Oct-1 binding motif was also shown to be responsive to phorbol 12-myristate 13-acetate but not LPS stimulation.	Tetradecanoylphorbol Acetate	59-90	solute carrier family 22 member 1	Bos taurus	4-9
2467914-7	1988	This agent induces a higher level of c-myc mRNA in the cells and stimulates the incorporation of [3H]thymidine into DNA; although these effects are partially counteracted by interferon or TPA treatment, the elevated expression of the c-myc gene may be sufficient to prevent terminal differentiation and allow cell proliferation to continue.	Tetradecanoylphorbol Acetate	188-191	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	234-239
21165949-7	2011	The expression of ST3Gal I and II was mildly induced by phorbol-12-myristate-13-acetate (PMA), and PMA-induced expression of ST3Gal I and ST3Gal II was inhibited by NF-kappaB decoy oligodeoxynucleotides (ODN) but not by AP-1 decoy ODN.	Tetradecanoylphorbol Acetate	56-87	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	18-33
2463169-1	1988	An extracellular signal, such as phorbol-12-myristate-13-acetate (PMA), was found to reduce the c-myc expression in Burkitt lymphoma (BL) cells but augment the expression of the same gene in a B-lymphoblastoid cell line (B-LCL).	Tetradecanoylphorbol Acetate	33-64	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	96-101
21165949-7	2011	The expression of ST3Gal I and II was mildly induced by phorbol-12-myristate-13-acetate (PMA), and PMA-induced expression of ST3Gal I and ST3Gal II was inhibited by NF-kappaB decoy oligodeoxynucleotides (ODN) but not by AP-1 decoy ODN.	Tetradecanoylphorbol Acetate	56-87	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	18-26
21165949-7	2011	The expression of ST3Gal I and II was mildly induced by phorbol-12-myristate-13-acetate (PMA), and PMA-induced expression of ST3Gal I and ST3Gal II was inhibited by NF-kappaB decoy oligodeoxynucleotides (ODN) but not by AP-1 decoy ODN.	Tetradecanoylphorbol Acetate	89-92	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	18-33
21165949-7	2011	The expression of ST3Gal I and II was mildly induced by phorbol-12-myristate-13-acetate (PMA), and PMA-induced expression of ST3Gal I and ST3Gal II was inhibited by NF-kappaB decoy oligodeoxynucleotides (ODN) but not by AP-1 decoy ODN.	Tetradecanoylphorbol Acetate	89-92	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	18-26
21165949-7	2011	The expression of ST3Gal I and II was mildly induced by phorbol-12-myristate-13-acetate (PMA), and PMA-induced expression of ST3Gal I and ST3Gal II was inhibited by NF-kappaB decoy oligodeoxynucleotides (ODN) but not by AP-1 decoy ODN.	Tetradecanoylphorbol Acetate	99-102	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	18-33
21165949-7	2011	The expression of ST3Gal I and II was mildly induced by phorbol-12-myristate-13-acetate (PMA), and PMA-induced expression of ST3Gal I and ST3Gal II was inhibited by NF-kappaB decoy oligodeoxynucleotides (ODN) but not by AP-1 decoy ODN.	Tetradecanoylphorbol Acetate	99-102	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	18-26
2463169-1	1988	An extracellular signal, such as phorbol-12-myristate-13-acetate (PMA), was found to reduce the c-myc expression in Burkitt lymphoma (BL) cells but augment the expression of the same gene in a B-lymphoblastoid cell line (B-LCL).	Tetradecanoylphorbol Acetate	66-69	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	96-101
3145405-1	1988	Platelet-derived growth factor (PDGF), the calcium ionophore A23187, and the tumor promoter phorbol myristate acetate stimulated c-fos mRNA levels in control NIH 3T3 cells.	Tetradecanoylphorbol Acetate	92-117	FBJ osteosarcoma oncogene	Mus musculus	129-134
2844823-1	1988	Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells.	Tetradecanoylphorbol Acetate	0-25	thrombomodulin	Mus musculus	66-80
21906096-12	2011	There was a moderate correlation between mDPA and TPA (r(2)=0.49, P&lt;.0001).	Tetradecanoylphorbol Acetate	50-53	D-phenylalanine	Mus musculus	41-45
3262618-1	1988	By use of an enzyme-linked immunosorbent assay, we have found that phorbol 12-myristate 13-acetate (PMA) causes an approximately 10-fold increase in the level of type-1 plasminogen activator inhibitor (PAI-1) accumulated in conditioned medium of the human rhabdomyosarcoma cell line.	Tetradecanoylphorbol Acetate	67-98	serpin family E member 1	Homo sapiens	202-207
21730054-5	2011	Here we studied the molecular mechanism of H1R up-regulation in HeLa cells that express H1R endogenously in response to histamine and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	134-165	histamine receptor H1	Homo sapiens	43-46
21730054-5	2011	Here we studied the molecular mechanism of H1R up-regulation in HeLa cells that express H1R endogenously in response to histamine and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	134-165	histamine receptor H1	Homo sapiens	88-91
21730054-5	2011	Here we studied the molecular mechanism of H1R up-regulation in HeLa cells that express H1R endogenously in response to histamine and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	167-170	histamine receptor H1	Homo sapiens	43-46
21730054-5	2011	Here we studied the molecular mechanism of H1R up-regulation in HeLa cells that express H1R endogenously in response to histamine and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	167-170	histamine receptor H1	Homo sapiens	88-91
3262618-1	1988	By use of an enzyme-linked immunosorbent assay, we have found that phorbol 12-myristate 13-acetate (PMA) causes an approximately 10-fold increase in the level of type-1 plasminogen activator inhibitor (PAI-1) accumulated in conditioned medium of the human rhabdomyosarcoma cell line.	Tetradecanoylphorbol Acetate	100-103	serpin family E member 1	Homo sapiens	202-207
3262618-7	1988	The protein synthesis inhibitor cycloheximide (10 micrograms/ml) also increased the level of PAI-1 mRNA, and when both cycloheximide and PMA were used, an additive effect was observed.	Tetradecanoylphorbol Acetate	137-140	serpin family E member 1	Homo sapiens	93-98
21468691-3	2011	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) gradually up-regulated the expression of ASK1 mRNA and protein, and subsequently enhanced its catalytic activity in MCF-7 cells.	Tetradecanoylphorbol Acetate	23-54	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	102-106
21468691-3	2011	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) gradually up-regulated the expression of ASK1 mRNA and protein, and subsequently enhanced its catalytic activity in MCF-7 cells.	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	102-106
3139763-3	1988	In this study we have investigated the effects of calcitriol and PMA-induced differentiation on the comparative expression of PA and PAI in monoblast-like U937 cells.	Tetradecanoylphorbol Acetate	65-68	serpin family B member 2	Homo sapiens	133-136
21596133-7	2011	Conversely, PKC activator phorbol ester (PMA) enhanced the expression level of another ERRalpha-target gene pyruvate dehydrogenase kinase 4 (PDK4).	Tetradecanoylphorbol Acetate	41-44	protein kinase C epsilon	Homo sapiens	12-15
2971556-0	1988	12-O-tetradecanoylphorbol-13-acetate disrupts actin filaments and focal contacts and enhances binding of fibronectin-coated latex beads to 3T3-L1 cells.	Tetradecanoylphorbol Acetate	0-36	fibronectin 1	Mus musculus	105-116
21142820-5	2011	Apigenin significantly inhibits the inductive effect of phorbol 12-myristate 13-acetate (PMA) plus A23187 on the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF).	Tetradecanoylphorbol Acetate	56-87	colony stimulating factor 2	Homo sapiens	223-271
2971556-11	1988	These results suggest that TPA specifically enhances the binding of fibronectin-coated beads to 3T3-L1 cells, and that TPA-induced binding of the beads may be related to disruption of focal contacts and reorganization of actin filaments.	Tetradecanoylphorbol Acetate	27-30	fibronectin 1	Mus musculus	68-79
21142820-5	2011	Apigenin significantly inhibits the inductive effect of phorbol 12-myristate 13-acetate (PMA) plus A23187 on the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF).	Tetradecanoylphorbol Acetate	56-87	colony stimulating factor 2	Homo sapiens	273-279
21804018-4	2011	Moreover, PMA-induced IL-1beta production was significantly reduced in the presence of TLR2, TLR4, and CD11b Abs.	Tetradecanoylphorbol Acetate	10-13	toll like receptor 4	Homo sapiens	93-97
2971556-11	1988	These results suggest that TPA specifically enhances the binding of fibronectin-coated beads to 3T3-L1 cells, and that TPA-induced binding of the beads may be related to disruption of focal contacts and reorganization of actin filaments.	Tetradecanoylphorbol Acetate	119-122	fibronectin 1	Mus musculus	68-79
21705328-4	2011	Small interfering RNA (siRNA) experiments indicated that knocking down the NADPH oxidase components e.g. Rac1, p22(phox), p67(phox), and NOXO1 in A549 cells impaired TPA-induced MnSOD expression.	Tetradecanoylphorbol Acetate	166-169	calcineurin like EF-hand protein 1	Homo sapiens	111-114
3139896-5	1988	In nine patients the platelet-released PAI contribution was determined by in vitro activation of platelets with phorbol-myristate-acetate (PMA).	Tetradecanoylphorbol Acetate	112-137	serpin family E member 1	Homo sapiens	39-42
21705328-4	2011	Small interfering RNA (siRNA) experiments indicated that knocking down the NADPH oxidase components e.g. Rac1, p22(phox), p67(phox), and NOXO1 in A549 cells impaired TPA-induced MnSOD expression.	Tetradecanoylphorbol Acetate	166-169	NADPH oxidase organizer 1	Homo sapiens	137-142
3139896-5	1988	In nine patients the platelet-released PAI contribution was determined by in vitro activation of platelets with phorbol-myristate-acetate (PMA).	Tetradecanoylphorbol Acetate	139-142	serpin family E member 1	Homo sapiens	39-42
3139896-8	1988	In the nine patients who were subjected to studies with in vitro activation, the preoperative PAI level (4.0 +/- 0.9 U/ml) was elevated to 5.1 +/- 0.7 U/ml (p = 0.001) with PMA induction.	Tetradecanoylphorbol Acetate	173-176	serpin family E member 1	Homo sapiens	94-97
2843535-4	1988	The protein kinase C activator, phorbol 12-myristate 13-acetate, at concentrations (2-20 nM) which did not deplete protein kinase C, stimulated LH-beta mRNA levels 2-5-fold after 24 h. Higher concentrations of phorbol 12-myristate 13-acetate, which depleted protein kinase C activity, substantially reduced the ability of 100 pM GnRH to stimulate increases in LH-beta mRNA levels.	Tetradecanoylphorbol Acetate	32-63	gonadotropin releasing hormone 1	Rattus norvegicus	329-333
21490247-3	2011	inhibits the expression of EBV lytic proteins, including Rta, Zta, EA-D and VCA, in P3HR1 cells after lytic induction with 12-O-tetradecanoylphorbol-13-acetate and sodium butyrate.	Tetradecanoylphorbol Acetate	123-159	MAS related GPR family member F	Homo sapiens	57-60
3139753-1	1988	We have previously shown that Lyt-2- L3T4- T cells from the lymph nodes of MRL/lpr/lpr mice could respond to 12-O-tetradecanoylphorbol-2-acetate (TPA) and A23187 by proliferation, IL-2 secretion, and IL-2R (IL-2R) expression.	Tetradecanoylphorbol Acetate	146-149	interleukin 2	Mus musculus	180-184
3409220-5	1988	RNA blot analysis has shown that p32 mRNA is induced as early as 0.5 h after the addition of 12-O-tetradecanoyl-phorbol-13-acetate or sodium arsenite.	Tetradecanoylphorbol Acetate	93-130	complement component 1, q subcomponent binding protein	Mus musculus	33-36
21741361-5	2011	In lipopolysaccharide (LPS)-stimulated Raw 264.7 cells and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse edema model, transduced PEP-1-HO-1 fusion proteins effectively inhibited the overexpression of pro-inflammatory mediators and cytokines.	Tetradecanoylphorbol Acetate	59-95	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	140-145
21741361-5	2011	In lipopolysaccharide (LPS)-stimulated Raw 264.7 cells and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse edema model, transduced PEP-1-HO-1 fusion proteins effectively inhibited the overexpression of pro-inflammatory mediators and cytokines.	Tetradecanoylphorbol Acetate	97-100	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	140-145
3409475-6	1988	In contrast, another single-step, high dose MCA transformant (MCACl#16/39) known to contain an activated c-Ki-ras gene shows TPA-independent focus formation in mixed culture with C3H/10T1/2 cells, anchorage independence and tumorigenicity.	Tetradecanoylphorbol Acetate	125-128	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	105-113
2840984-0	1988	Monocyte-associated tissue factor is suppressed by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	51-76	coagulation factor III, tissue factor	Homo sapiens	20-33
21288594-5	2011	Lipopolysaccharide (LPS)- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated Raw 264.7 cells and ICR mice were treated with PEP-1-FK506BP.	Tetradecanoylphorbol Acetate	29-65	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	130-135
21288594-5	2011	Lipopolysaccharide (LPS)- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated Raw 264.7 cells and ICR mice were treated with PEP-1-FK506BP.	Tetradecanoylphorbol Acetate	29-65	FK506 binding protein 1a	Mus musculus	136-143
2840984-4	1988	Phorbol myristate acetate (PMA) induced an increase in tissue factor activity at low doses (10(-11) to 10(-12) mol/L).	Tetradecanoylphorbol Acetate	0-25	coagulation factor III, tissue factor	Homo sapiens	55-68
21684020-2	2011	We found that LPS stimulated the intracellular accumulation of reactive oxygen species (ROS) and MOR expression in macrophage-like TPA-HL-60 cells.	Tetradecanoylphorbol Acetate	131-134	opioid receptor mu 1	Homo sapiens	97-100
2840984-4	1988	Phorbol myristate acetate (PMA) induced an increase in tissue factor activity at low doses (10(-11) to 10(-12) mol/L).	Tetradecanoylphorbol Acetate	27-30	coagulation factor III, tissue factor	Homo sapiens	55-68
21684020-3	2011	Conditioned medium from the LPS-stimulated TPA-HL-60 cells increased MOR expression in SH-SY5Y cells, a neuronal cell model, through actions mediated by TNF-alpha and GM-CSF.	Tetradecanoylphorbol Acetate	43-46	opioid receptor mu 1	Homo sapiens	69-72
21684020-3	2011	Conditioned medium from the LPS-stimulated TPA-HL-60 cells increased MOR expression in SH-SY5Y cells, a neuronal cell model, through actions mediated by TNF-alpha and GM-CSF.	Tetradecanoylphorbol Acetate	43-46	colony stimulating factor 2	Homo sapiens	167-173
2840984-5	1988	Conversely, concentrations of PMA that stimulate release of oxygen metabolites or that cause the cytosol-to-membrane translocation of protein kinase C (PKC) (10(-9) to 10(-7) mol/L) resulted in a rapid decrease in both adherence-induced and endotoxin-induced monocyte tissue factor activity.	Tetradecanoylphorbol Acetate	30-33	coagulation factor III, tissue factor	Homo sapiens	268-281
3135944-0	1988	Antioxidants inhibit proliferation and cell surface expression of receptors for interleukin-2 and transferrin in T lymphocytes stimulated with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	143-168	interleukin 2	Mus musculus	80-93
3142093-5	1988	Cells that were induced with PMA but not with RA or DMF also produced an inhibitor to UK that was identified as PAI-2, the plasminogen activator inhibitor that is produced by monocytes.	Tetradecanoylphorbol Acetate	29-32	serpin family B member 2	Homo sapiens	123-154
3164253-4	1988	Platelet aggregation and the phosphorylation of a platelet Mr 47,000 protein (p47) induced by phorbol-12-myristate-13-acetate (PMA) represent two processes mediated by PKC.	Tetradecanoylphorbol Acetate	94-125	pleckstrin	Homo sapiens	78-81
3164253-4	1988	Platelet aggregation and the phosphorylation of a platelet Mr 47,000 protein (p47) induced by phorbol-12-myristate-13-acetate (PMA) represent two processes mediated by PKC.	Tetradecanoylphorbol Acetate	127-130	pleckstrin	Homo sapiens	78-81
3164643-2	1988	The monocytic inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) was found to specifically stimulate phosphorylation of histone H2B in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	22-58	H2B clustered histone 21	Homo sapiens	128-131
3164643-2	1988	The monocytic inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) was found to specifically stimulate phosphorylation of histone H2B in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	60-63	H2B clustered histone 21	Homo sapiens	128-131
3136322-8	1988	Studies in vivo and in vitro with various mutants of the dyad symmetry element indicate that c-fos activation by polypeptide growth factors and 12-O-tetradecanoyl activation by polypeptide growth factors and 12-O-tetradecanoyl phorbol-13-acetate is mediated by a common transcription factor, and that this factor is identical to the previously described serum response factor.	Tetradecanoylphorbol Acetate	208-245	serum response factor	Rattus norvegicus	354-375
3260374-1	1988	Expression of the epidermal growth factor (EGF) receptor gene is stimulated by EGF and the phorbol ester, 4 beta-phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	106-144	epidermal growth factor	Homo sapiens	43-46
3260374-1	1988	Expression of the epidermal growth factor (EGF) receptor gene is stimulated by EGF and the phorbol ester, 4 beta-phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	146-149	epidermal growth factor	Homo sapiens	43-46
22461904-6	2012	The further mechanistic studies showed that JWA deficiency blocked TPA-induced activation of MAPKs and its downstream transcription factor Elk1 both in vitro and in vivo.	Tetradecanoylphorbol Acetate	67-70	ELK1, member of ETS oncogene family	Mus musculus	139-143
2458497-5	1988	Flow cytometric analyses using the McAb H2B4 revealed that the amount of p60c-src expression in K562 cells markedly decreased during TPA induced differentiation.	Tetradecanoylphorbol Acetate	133-136	CD244 molecule	Homo sapiens	40-44
22461904-7	2012	JWA(Delta2/Delta2) mice are resistance to tumorigenesis induced by DMBA/TPA probably through inhibition of transcription factor Elk1 via MAPKs.	Tetradecanoylphorbol Acetate	72-75	ELK1, member of ETS oncogene family	Mus musculus	128-132
22384062-3	2012	PRINCIPAL FINDINGS: Here we show that RNAi-mediated knockdown of PKCepsilon in H358, H1299, H322, and A549 NSCLC impairs activation of the small GTPase Rac1 in response to phorbol 12-myristate 13-acetate (PMA), serum, or epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	172-203	protein kinase C epsilon	Homo sapiens	65-75
22384062-3	2012	PRINCIPAL FINDINGS: Here we show that RNAi-mediated knockdown of PKCepsilon in H358, H1299, H322, and A549 NSCLC impairs activation of the small GTPase Rac1 in response to phorbol 12-myristate 13-acetate (PMA), serum, or epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	205-208	protein kinase C epsilon	Homo sapiens	65-75
2833544-8	1988	Treatment of the hybrid cells with 12-O-tetradecanoyl phorbol-13-acetate reversed the suppression of TCR-alpha gene transcription, but TCR-gamma gene transcription was not recovered by the same treatment.	Tetradecanoylphorbol Acetate	35-72	T cell receptor alpha chain	Mus musculus	101-110
22299029-1	2012	We have previously shown that TPA activates HTLV-1 LTR in Jurkat T-cells by inducing the binding of Sp1-p53 complex to the Sp1 site residing within the Ets responsive region 1 (ERR-1) of the LTR and that this activation is inhibited by PKCalpha and PKCepsilon.	Tetradecanoylphorbol Acetate	30-33	protein kinase C epsilon	Homo sapiens	249-259
2965729-7	1988	The presence of precursor cells for IL-2 production is supported by experiments showing that the combination of calcium ionophores and PMA elicits IL-2 production by spleen cells from both normal and T. cruzi-infected mice.	Tetradecanoylphorbol Acetate	135-138	interleukin 2	Mus musculus	36-40
22253701-9	2012	In kidney-derived CV1 and choriocarcinoma-derived JEG3 cells, pBL-FFL-CAT5, but not pBL-CAT5, was strongly activated by a protein kinase C activator, phorbol 12-O-tetradecanoate-13-acetate (TPA).	Tetradecanoylphorbol Acetate	190-193	coenzyme Q7, hydroxylase	Homo sapiens	70-74
22253701-10	2012	TPA-induced activity of pBL-FFL-CAT5 was negatively regulated by T3/TR.	Tetradecanoylphorbol Acetate	0-3	coenzyme Q7, hydroxylase	Homo sapiens	32-36
2965729-7	1988	The presence of precursor cells for IL-2 production is supported by experiments showing that the combination of calcium ionophores and PMA elicits IL-2 production by spleen cells from both normal and T. cruzi-infected mice.	Tetradecanoylphorbol Acetate	135-138	interleukin 2	Mus musculus	147-151
2838419-5	1988	However, exposure of monocytes to recombinant IL 1 alpha or IL 1 beta resulted in enhanced generation of superoxide response following stimulation with PMA.	Tetradecanoylphorbol Acetate	152-155	interleukin 1 alpha	Homo sapiens	46-56
21989206-8	2011	KEY FINDINGS: Transduced PEP-1-CypA protein markedly inhibited lipopolysaccharide- and 12-O-tetradecanoyl phorbol-13-acetate-induced expression levels of COX-2 as well as pro-inflammatory cytokine levels in vitro and in vivo.	Tetradecanoylphorbol Acetate	87-124	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	25-30
2897079-5	1988	However, in contrast to TPA, EGF increased the phosphorylation of the c-erbB-2 protein in cells whose protein kinase C had been down-regulated by long-term pretreatment with TPA, suggesting that EGF and TPA induce phosphorylation by different mechanisms.	Tetradecanoylphorbol Acetate	174-177	epidermal growth factor	Homo sapiens	29-32
24371557-4	2011	In addition, Helios (-/-) was remarkably resistant against phorbol 12-myristate 13-acetate (PMA)/ionomycin treatment, which mimics the B cell receptor (BCR)-mediated stimulation.	Tetradecanoylphorbol Acetate	59-90	IKAROS family zinc finger 2	Gallus gallus	13-19
2897079-5	1988	However, in contrast to TPA, EGF increased the phosphorylation of the c-erbB-2 protein in cells whose protein kinase C had been down-regulated by long-term pretreatment with TPA, suggesting that EGF and TPA induce phosphorylation by different mechanisms.	Tetradecanoylphorbol Acetate	174-177	epidermal growth factor	Homo sapiens	195-198
24371557-4	2011	In addition, Helios (-/-) was remarkably resistant against phorbol 12-myristate 13-acetate (PMA)/ionomycin treatment, which mimics the B cell receptor (BCR)-mediated stimulation.	Tetradecanoylphorbol Acetate	92-95	IKAROS family zinc finger 2	Gallus gallus	13-19
24371557-6	2011	The resistance against the PMA/ionomycin-induced apoptosis of Helios (-/-) was sensitive to Rottlerin but not to Go6976.	Tetradecanoylphorbol Acetate	27-30	IKAROS family zinc finger 2	Gallus gallus	62-68
2897079-5	1988	However, in contrast to TPA, EGF increased the phosphorylation of the c-erbB-2 protein in cells whose protein kinase C had been down-regulated by long-term pretreatment with TPA, suggesting that EGF and TPA induce phosphorylation by different mechanisms.	Tetradecanoylphorbol Acetate	174-177	epidermal growth factor	Homo sapiens	29-32
2897079-5	1988	However, in contrast to TPA, EGF increased the phosphorylation of the c-erbB-2 protein in cells whose protein kinase C had been down-regulated by long-term pretreatment with TPA, suggesting that EGF and TPA induce phosphorylation by different mechanisms.	Tetradecanoylphorbol Acetate	174-177	epidermal growth factor	Homo sapiens	195-198
2828363-5	1988	To assess whether TPA could be a secretagogue that promotes the biosynthesis of PAF through the dithiothreitol-insensitive cholinephosphotransferase pathway, this enzymic activity was assayed in homogenates from PMN preincubated in the presence of several secretagogues.	Tetradecanoylphorbol Acetate	18-21	PCNA clamp associated factor	Homo sapiens	80-83
27721335-6	2011	By contrast, the PKC activator phorbol-12-myristate-13-acetate (PMA) induced translocation of PKCbetaII-EGFP which was sustained and independent of calcium or TRPV1.	Tetradecanoylphorbol Acetate	31-62	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	159-164
27721335-6	2011	By contrast, the PKC activator phorbol-12-myristate-13-acetate (PMA) induced translocation of PKCbetaII-EGFP which was sustained and independent of calcium or TRPV1.	Tetradecanoylphorbol Acetate	64-67	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	159-164
2828363-7	1988	However, TPA did enhance the incorporation of [methyl-3H]choline and both alkyl- and acetyl-labeled 1-O-hexadecyl-2-acetyl-sn-glycerol into a lipid fraction co-migrating with PAF.	Tetradecanoylphorbol Acetate	9-12	PCNA clamp associated factor	Homo sapiens	175-178
27721335-7	2011	In addition PMA-induced sensitization of TRPV1 to capsaicin response in DRG neurons was attenuated by PKCbetaII blocker CGP 53353.	Tetradecanoylphorbol Acetate	12-15	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	41-46
2828363-8	1988	This incorporation showed a time course parallel to that of the generation of PAF in response to TPA.	Tetradecanoylphorbol Acetate	97-100	PCNA clamp associated factor	Homo sapiens	78-81
21730054-12	2011	U0126, an MEK inhibitor, and DPQ, a poly(ADP-ribose) polymerase-1 inhibitor, suppressed PMA-induced up-regulation of H1R gene expression.	Tetradecanoylphorbol Acetate	88-91	histamine receptor H1	Homo sapiens	117-120
2828363-9	1988	Incubation of [methyl-3H]choline-labeled cells in the presence of 1-O-hexadecyl-2-acetyl-sn-glycerol caused an enhanced incorporation of the label into the fraction co-migrating as PAF, and this incorporation was synergistically enhanced by TPA.	Tetradecanoylphorbol Acetate	241-244	PCNA clamp associated factor	Homo sapiens	181-184
21730054-16	2011	These results suggest the involvement of the PKCdelta/ERK/poly(ADP-ribose) polymerase-1 signaling pathway in histamine- or PMA-induced up-regulation of H1R gene expression in HeLa cells.	Tetradecanoylphorbol Acetate	123-126	histamine receptor H1	Homo sapiens	152-155
2828363-10	1988	Pulse-chase experiments with choline showed that TPA caused an early accumulation of choline into phosphatidylcholine and PAF rather than into CDP-choline.	Tetradecanoylphorbol Acetate	49-52	PCNA clamp associated factor	Homo sapiens	122-125
2828363-11	1988	The present data indicate that TPA is the only agonist that could initiate the biosynthesis of PAF in human PMN through the cholinephosphotransferase pathway and that this process of biosynthesis is regulated at an enzyme step other than dithiothreitol-insensitive cholinephosphotransferase.	Tetradecanoylphorbol Acetate	31-34	PCNA clamp associated factor	Homo sapiens	95-98
21673231-0	2011	Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells.	Tetradecanoylphorbol Acetate	62-65	pyruvate kinase M1/2	Homo sapiens	74-78
21673231-7	2011	We observed that increased expression and activity of PKM2 in TPA-treated JB6 P+ cells and pretreatment with succinate or malate/pyruvate suppressed the effects.	Tetradecanoylphorbol Acetate	62-65	pyruvate kinase M1/2	Homo sapiens	54-58
21665893-4	2011	Knockdown of endogenous PKD1 or PKD2 decreased extracellular signal-regulated kinase (ERK) 1/2 and nuclear factor-kappaB (NF-kappaB)-dependent transcriptional activities and potentiated PMA-induced apoptosis, whereas overexpression of wild-type PKD1 enhanced ERK1/2 activity and suppressed PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	186-189	polycystin 1, transient receptor potential channel interacting	Homo sapiens	24-28
2893824-11	1988	The expression of TRF/IL-5 mRNA in B151K12 was augmented by the stimulation with PMA plus calcium ionophore.	Tetradecanoylphorbol Acetate	81-84	interleukin 5	Mus musculus	18-21
21665893-4	2011	Knockdown of endogenous PKD1 or PKD2 decreased extracellular signal-regulated kinase (ERK) 1/2 and nuclear factor-kappaB (NF-kappaB)-dependent transcriptional activities and potentiated PMA-induced apoptosis, whereas overexpression of wild-type PKD1 enhanced ERK1/2 activity and suppressed PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	186-189	polycystin 1, transient receptor potential channel interacting	Homo sapiens	245-249
21665893-4	2011	Knockdown of endogenous PKD1 or PKD2 decreased extracellular signal-regulated kinase (ERK) 1/2 and nuclear factor-kappaB (NF-kappaB)-dependent transcriptional activities and potentiated PMA-induced apoptosis, whereas overexpression of wild-type PKD1 enhanced ERK1/2 activity and suppressed PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	290-293	polycystin 1, transient receptor potential channel interacting	Homo sapiens	24-28
21665893-9	2011	In summary, our data indicate that PKD1 is activated and downregulated by PMA through a PKC-dependent ubiquitin-proteasome degradation pathway, and the activation of PKD1 or PKD2 counteracts PMA-induced apoptosis by promoting downstream ERK1/2 and NF-kappaB activities in LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	74-77	polycystin 1, transient receptor potential channel interacting	Homo sapiens	35-39
21665893-9	2011	In summary, our data indicate that PKD1 is activated and downregulated by PMA through a PKC-dependent ubiquitin-proteasome degradation pathway, and the activation of PKD1 or PKD2 counteracts PMA-induced apoptosis by promoting downstream ERK1/2 and NF-kappaB activities in LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	74-77	polycystin 1, transient receptor potential channel interacting	Homo sapiens	166-170
3342035-3	1988	Furthermore, CsH, like CsA, inhibits the Ca2+/calmodulin-dependent phosphorylation of the elongation factor 2 (EF-2) in vitro and the TPA-induced increases in the amount of EF-2 in vivo.	Tetradecanoylphorbol Acetate	134-137	eukaryotic translation elongation factor 2	Mus musculus	111-115
21663586-1	2011	Plasminogen activator inhibitor (PAI-1) is a fast acting inhibitor of tissue and urokinase plasminogen activators (tPA and uPA).	Tetradecanoylphorbol Acetate	115-118	serpin family E member 1	Homo sapiens	33-38
21663586-3	2011	PAI-1 plays an important role in blood coagulation controlling clot lysis which is triggered by tPA activated plasminogen [4].	Tetradecanoylphorbol Acetate	96-99	serpin family E member 1	Homo sapiens	0-5
3342035-3	1988	Furthermore, CsH, like CsA, inhibits the Ca2+/calmodulin-dependent phosphorylation of the elongation factor 2 (EF-2) in vitro and the TPA-induced increases in the amount of EF-2 in vivo.	Tetradecanoylphorbol Acetate	134-137	eukaryotic translation elongation factor 2	Mus musculus	173-177
3342035-6	1988	Inhibition of TPA-effects may involve suppression of calmodulin-dependent processes, such as augmentation and phosphorylation of EF-2.	Tetradecanoylphorbol Acetate	14-17	eukaryotic translation elongation factor 2	Mus musculus	129-133
21045076-10	2011	Inhibition of SOD2 reduced the PMA-induced respiratory burst and IL1A, IL-1R1, IL-1R2 and IL8RA gene expression in neutrophil-differentiated HL60 cells.	Tetradecanoylphorbol Acetate	31-34	interleukin 1 alpha	Homo sapiens	65-69
2470302-1	1988	Keratinocytes in culture produce detectable amounts of IL-1 alpha mRNA constitutively and can be stimulated to express increased amounts of IL-1 alpha mRNA by cycloheximide, PMA, and retinoic acid.	Tetradecanoylphorbol Acetate	174-177	interleukin 1 alpha	Homo sapiens	55-65
2470302-1	1988	Keratinocytes in culture produce detectable amounts of IL-1 alpha mRNA constitutively and can be stimulated to express increased amounts of IL-1 alpha mRNA by cycloheximide, PMA, and retinoic acid.	Tetradecanoylphorbol Acetate	174-177	interleukin 1 alpha	Homo sapiens	140-150
21463955-4	2011	TSLP mRNA was expressed by phorbol myristate acetate (PMA) plus A23187 stimulation in HMC-1 cells and reached its peak 5h after PMA plus A23187 stimulation.	Tetradecanoylphorbol Acetate	27-52	thymic stromal lymphopoietin	Homo sapiens	0-4
2470302-3	1988	RU 486, which interferes with glucocorticosteroid-receptor binding, decreases inhibition of TPA stimulation of IL-1 alpha mRNA by dexamethasone, which suggests that the inhibition by dexamethasone is through a conventional ligand-receptor mechanism.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 alpha	Homo sapiens	111-121
21463955-4	2011	TSLP mRNA was expressed by phorbol myristate acetate (PMA) plus A23187 stimulation in HMC-1 cells and reached its peak 5h after PMA plus A23187 stimulation.	Tetradecanoylphorbol Acetate	54-57	thymic stromal lymphopoietin	Homo sapiens	0-4
3275474-2	1988	On stimulation with endotoxin or with phorbol myristate acetate (PMA), TF of these cells is known to be increased approximately fourfold.	Tetradecanoylphorbol Acetate	38-63	coagulation factor III, tissue factor	Homo sapiens	71-73
21381898-5	2011	Phorbol-12-myristate-13-acetate (PMA) is an activator of NOX and it was found that PMA treatment of human colon carcinoma cells both increased cellular ROS levels and subsequently up-regulated GGT expression.	Tetradecanoylphorbol Acetate	0-31	gamma-glutamyltransferase light chain family member 3	Homo sapiens	193-196
21381898-5	2011	Phorbol-12-myristate-13-acetate (PMA) is an activator of NOX and it was found that PMA treatment of human colon carcinoma cells both increased cellular ROS levels and subsequently up-regulated GGT expression.	Tetradecanoylphorbol Acetate	33-36	gamma-glutamyltransferase light chain family member 3	Homo sapiens	193-196
3275474-2	1988	On stimulation with endotoxin or with phorbol myristate acetate (PMA), TF of these cells is known to be increased approximately fourfold.	Tetradecanoylphorbol Acetate	65-68	coagulation factor III, tissue factor	Homo sapiens	71-73
2961801-2	1987	In the present study, CD4 and CD8 were modified by increased phosphorylation when T cell clones or T cells were either exposed to phorbol-12-myristate- 13-acetate or were triggered via the CD3-T cell receptor complex.	Tetradecanoylphorbol Acetate	130-162	T-cell surface glycoprotein CD4	Ovis aries	22-25
21391601-2	2011	The results were compared to those obtained from c9,t11-CLA, which is a more effective anti-tumor promoter on TPA-induced GJIC inhibition in MCF-10A cells than t10,c12-CLA.	Tetradecanoylphorbol Acetate	110-113	selectin P ligand	Homo sapiens	56-59
2961801-5	1987	Furthermore, phorbol myristate acetate treatment or activation via the CD2 pathway induced phosphorylation of the CD4 and CD8 molecules of thymocytes, suggesting that these molecules may be functional in thymus.	Tetradecanoylphorbol Acetate	13-38	T-cell surface glycoprotein CD4	Ovis aries	114-117
21391601-4	2011	Suppression of TPA-induced reactive oxygen species (ROS) generation by t9,t11-CLA and t10,t12-CLA was less effective, relative to c9,t11-CLA.	Tetradecanoylphorbol Acetate	15-18	selectin P ligand	Homo sapiens	78-81
21391601-4	2011	Suppression of TPA-induced reactive oxygen species (ROS) generation by t9,t11-CLA and t10,t12-CLA was less effective, relative to c9,t11-CLA.	Tetradecanoylphorbol Acetate	15-18	selectin P ligand	Homo sapiens	94-97
21391601-4	2011	Suppression of TPA-induced reactive oxygen species (ROS) generation by t9,t11-CLA and t10,t12-CLA was less effective, relative to c9,t11-CLA.	Tetradecanoylphorbol Acetate	15-18	selectin P ligand	Homo sapiens	94-97
21391601-5	2011	The results suggest that the anti-promotional activities of t9,t11-CLA and t10,t12-CLA are equal but less potent than c9,t11-CLA in TPA-treated MCF-10A cells.	Tetradecanoylphorbol Acetate	132-135	selectin P ligand	Homo sapiens	67-70
21391601-5	2011	The results suggest that the anti-promotional activities of t9,t11-CLA and t10,t12-CLA are equal but less potent than c9,t11-CLA in TPA-treated MCF-10A cells.	Tetradecanoylphorbol Acetate	132-135	selectin P ligand	Homo sapiens	83-86
21391601-5	2011	The results suggest that the anti-promotional activities of t9,t11-CLA and t10,t12-CLA are equal but less potent than c9,t11-CLA in TPA-treated MCF-10A cells.	Tetradecanoylphorbol Acetate	132-135	selectin P ligand	Homo sapiens	83-86
3436883-7	1987	Because PMA, NH4Cl, methylamine, imidazole, HEPES-buffered solutions, and low-Cl- solutions can cause increases in pHi and amiloride and acetate can cause decreases in pHi, these results suggest that intracellular alkalosis and acidosis, respectively, potentiate and blunt vasoconstrictor responses to hypoxia and other stimuli in isolated rat lungs.	Tetradecanoylphorbol Acetate	8-11	glucose-6-phosphate isomerase	Rattus norvegicus	115-118
21297032-3	2011	However, in a previous study we reported that the protein kinase C (PKC)-agonist PMA could induce a sustained activation of Nox5 that was independent of calcium changes.	Tetradecanoylphorbol Acetate	81-84	NADPH oxidase 5	Homo sapiens	124-128
21297032-7	2011	The inhibition of MEK1 using PD-98059 and U-0126 significantly reduced the phosphorylation and activity of Nox5 in response to PMA but not to the calcium-mobilizing stimulus ionomycin.	Tetradecanoylphorbol Acetate	127-130	mitogen-activated protein kinase kinase 1	Homo sapiens	18-22
21297032-7	2011	The inhibition of MEK1 using PD-98059 and U-0126 significantly reduced the phosphorylation and activity of Nox5 in response to PMA but not to the calcium-mobilizing stimulus ionomycin.	Tetradecanoylphorbol Acetate	127-130	NADPH oxidase 5	Homo sapiens	107-111
2820700-9	1987	TPA also increased the intracellular pH (pHi) of stationary cultures of Nb2 cells from 7.29 +/- 0.02 (n = 8) to a maximum of 7.45 +/- 0.03 (n = 10).	Tetradecanoylphorbol Acetate	0-3	glucose-6-phosphate isomerase	Rattus norvegicus	41-44
21480506-8	2011	Moreover, significant increases in the protein levels analyzed by ELISA of c-Jun, p65, and p53 were observed in the skin of DMBA/TPA treated mice, whereas mice treated with 2 and DMBA/TPA had a similar expression of these transcription factors than the control mice.	Tetradecanoylphorbol Acetate	129-132	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	82-85
21480506-8	2011	Moreover, significant increases in the protein levels analyzed by ELISA of c-Jun, p65, and p53 were observed in the skin of DMBA/TPA treated mice, whereas mice treated with 2 and DMBA/TPA had a similar expression of these transcription factors than the control mice.	Tetradecanoylphorbol Acetate	129-132	transformation related protein 53, pseudogene	Mus musculus	91-94
2820700-10	1987	The most rapid and greatest response was observed with 40 nM TPA which gave a detectable increase in pHi within 1 min and reached a maximum alkalinization by 6 min.	Tetradecanoylphorbol Acetate	61-64	glucose-6-phosphate isomerase	Rattus norvegicus	101-104
21324306-5	2011	In a mouse edema model, PEP-1-catalase inhibited the increased expressions of inflammatory mediators and cytokines such as cyclooxygenase-2, inducible nitric oxide synthase, interleukin-6 and -1beta, and tumor necrosis factor-alpha induced by TPA.	Tetradecanoylphorbol Acetate	243-246	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	24-29
2820700-13	1987	The TPA-induced increase in pHi was Na+-dependent and was inhibited by EP-Am and H-7.	Tetradecanoylphorbol Acetate	4-7	glucose-6-phosphate isomerase	Rattus norvegicus	28-31
2820700-14	1987	A preincubation with EP-Am (25 microM) for 5-10 min abolished the TPA-induced increase in pHi whereas prolonged incubation with H-7 (50 microM) for up to 3 h was required to decrease the stimulatory effect of TPA by approximately 50%.	Tetradecanoylphorbol Acetate	66-69	glucose-6-phosphate isomerase	Rattus norvegicus	90-93
3498728-5	1987	Under the same conditions, TPA decreased the level of muscular alpha-actin mRNA and increased that of nonmuscular beta- and gamma-actins mRNA.	Tetradecanoylphorbol Acetate	27-30	actin, beta	Gallus gallus	114-136
21575515-2	2011	METHODS: Phorbol 12-myristate 13-acetate (PMA) was used to induce the activity of SphK1 and N, N-dimethylsphingosine (DMS) was used to suppress the activity of SphK1.	Tetradecanoylphorbol Acetate	9-40	sphingosine kinase 1	Homo sapiens	82-87
2823875-5	1987	In U937 cells, the quantity of tissue factor mRNA was increased severalfold by exposure of the cells to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	104-135	coagulation factor III, tissue factor	Homo sapiens	31-44
21575515-2	2011	METHODS: Phorbol 12-myristate 13-acetate (PMA) was used to induce the activity of SphK1 and N, N-dimethylsphingosine (DMS) was used to suppress the activity of SphK1.	Tetradecanoylphorbol Acetate	42-45	sphingosine kinase 1	Homo sapiens	82-87
21501873-3	2011	In this communication we show that DR6 is not expressed in resting T cells from human peripheral blood or murine lymph nodes but that its expression is significantly upregulated in CD3 crosslinking- or PMA/ionomycin-activated T lymphocytes.	Tetradecanoylphorbol Acetate	202-205	TNF receptor superfamily member 21	Homo sapiens	35-38
21525011-2	2011	The BZLF1 promoter (Zp) normally exhibits only low basal activity but is activated in response to chemical inducers such as 12-O-tetradecanoylphorbol-13-acetate and calcium ionophore.	Tetradecanoylphorbol Acetate	124-160	protein Zta	Human gammaherpesvirus 4	4-9
21129147-7	2011	METHODS/RESULTS: Chromatin immunoprecipitation and gel-shift assays with phorbol 12-myristate 13-acetate-treated human erythroleukemia (HEL) cells revealed RUNX1 binding to RUNX1 consensus sites at -1774/-1769 and -157/-152 on the PF4 promoter.	Tetradecanoylphorbol Acetate	73-104	RUNX family transcription factor 1	Homo sapiens	156-161
3496927-9	1987	Only cells activated with TPA coexpressed B1 and T1 as well as B5 and IL-2R.	Tetradecanoylphorbol Acetate	26-29	membrane spanning 4-domains A1	Homo sapiens	42-51
21129147-7	2011	METHODS/RESULTS: Chromatin immunoprecipitation and gel-shift assays with phorbol 12-myristate 13-acetate-treated human erythroleukemia (HEL) cells revealed RUNX1 binding to RUNX1 consensus sites at -1774/-1769 and -157/-152 on the PF4 promoter.	Tetradecanoylphorbol Acetate	73-104	RUNX family transcription factor 1	Homo sapiens	173-178
3036146-3	1987	On the other hand, the addition of phorbol 12-myristate 13-acetate or NH4Cl causes a pertussis toxin-insensitive increase in cytoskeletal actin.	Tetradecanoylphorbol Acetate	35-66	actin	Oryctolagus cuniculus	138-143
21311105-7	2011	RESULTS: Alloferon effectively recovered the suppressed proliferation of BCBL-1 by TPA, which was achieved by the down-regulation of lytic-cycle-related viral genes, RTA, K8 and vIRF2.	Tetradecanoylphorbol Acetate	83-86	MAS related GPR family member F	Homo sapiens	166-169
21221132-8	2011	We also demonstrated that IKKe was able to enhance KSHV reactivation synergistically with the treatment of 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	107-143	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	26-30
3496224-3	1987	TPA stimulation of an interleukin 2 (IL 2)-producing variant, EL4+, induced a 3-4-fold increase in TCR beta, but not alpha, chain mRNA.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Mus musculus	22-35
21039753-0	2011	Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cdelta/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages.	Tetradecanoylphorbol Acetate	201-226	basigin (Ok blood group)	Homo sapiens	21-67
3496224-3	1987	TPA stimulation of an interleukin 2 (IL 2)-producing variant, EL4+, induced a 3-4-fold increase in TCR beta, but not alpha, chain mRNA.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Mus musculus	37-41
21039753-0	2011	Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cdelta/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages.	Tetradecanoylphorbol Acetate	201-226	basigin (Ok blood group)	Homo sapiens	69-76
21039753-3	2011	The aim of the present study was to explore whether artemisinin, a natural extract from Artemisia annua, could decrease EMMPRIN and MMP-9 expression in phorbol myristate acetate (PMA)-induced macrophages by regulating the protein kinase (PK) Cdelta/c-Jun N-terminal kinase (JNK)/p38/extracellular signal-regulated kinase (ERK) pathway.	Tetradecanoylphorbol Acetate	152-177	basigin (Ok blood group)	Homo sapiens	120-127
21039753-3	2011	The aim of the present study was to explore whether artemisinin, a natural extract from Artemisia annua, could decrease EMMPRIN and MMP-9 expression in phorbol myristate acetate (PMA)-induced macrophages by regulating the protein kinase (PK) Cdelta/c-Jun N-terminal kinase (JNK)/p38/extracellular signal-regulated kinase (ERK) pathway.	Tetradecanoylphorbol Acetate	179-182	basigin (Ok blood group)	Homo sapiens	120-127
21345949-7	2011	Moreover, overexpression of TRIM22 in 293T cells significantly impaired basal and phorbol myristate acetate-ionomycin-induced HIV-1 LTR-driven gene expression, whereas inhibition of tumor necrosis factor alpha-induced viral transcription was a consequence of lower basal expression.	Tetradecanoylphorbol Acetate	82-107	tripartite motif containing 22	Homo sapiens	28-34
3496224-3	1987	TPA stimulation of an interleukin 2 (IL 2)-producing variant, EL4+, induced a 3-4-fold increase in TCR beta, but not alpha, chain mRNA.	Tetradecanoylphorbol Acetate	0-3	T cell receptor beta chain	Mus musculus	99-107
3496224-6	1987	TPA stimulation of EL4+ cells also induced de novo expression of the IL 2 gene and subsequent secretion of this lymphokine.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Mus musculus	69-73
3496224-7	1987	However, the increased expression of the TCR beta-chain gene and the induction of the IL 2 gene were not linked since expression of TCR beta-chain mRNA was increased to a similar degree in EL4+ and IL 2-nonproducing EL4- sublines, and cyclosporin A selectively blocked TPA-induced IL 2-gene expression in EL4+ cells without affecting the increase in TCR beta-chain mRNA.	Tetradecanoylphorbol Acetate	269-272	interleukin 2	Mus musculus	86-90
21167782-4	2011	High levels of IL-4 mRNA expression were detected in spleen T cells of naive animals after in vitro stimulation with PMA plus ionomycin for 4-24 h. The expression of IL-4 mRNA was low in spleen and lymph node cells immunized with ovalbumin (OVA) plus Complete Freund"s Adjuvant (CFA) in response to OVA (Th1), but significantly higher in the guinea pigs immunized with OVA plus alum (Th2).	Tetradecanoylphorbol Acetate	117-120	interleukin-4	Cavia porcellus	15-19
21167782-4	2011	High levels of IL-4 mRNA expression were detected in spleen T cells of naive animals after in vitro stimulation with PMA plus ionomycin for 4-24 h. The expression of IL-4 mRNA was low in spleen and lymph node cells immunized with ovalbumin (OVA) plus Complete Freund"s Adjuvant (CFA) in response to OVA (Th1), but significantly higher in the guinea pigs immunized with OVA plus alum (Th2).	Tetradecanoylphorbol Acetate	117-120	interleukin-4	Cavia porcellus	166-170
3597558-0	1987	Differential induction of transcription of c-myc and c-fos proto-oncogenes by 12-O-tetradecanoylphorbol-13-acetate in mortal and immortal human urothelial cells.	Tetradecanoylphorbol Acetate	78-114	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	43-48
20826143-6	2010	Inhibitors of phosphatidylinositol 3-kinase (PI3-K), Akt, and phosphodiesterase 3B (PDE3B) diminished the PMA effect.	Tetradecanoylphorbol Acetate	106-109	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	14-43
21442679-3	2011	In this study, the effects of oleanolic acid and ursolic acid on MUC5AC mucin production and gene expression induced by epidermal growth factor (EGF) and phorbol 12-myristate 13-acetate (PMA) from human airway epithelial cells were investigated.	Tetradecanoylphorbol Acetate	154-185	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	65-71
21442679-3	2011	In this study, the effects of oleanolic acid and ursolic acid on MUC5AC mucin production and gene expression induced by epidermal growth factor (EGF) and phorbol 12-myristate 13-acetate (PMA) from human airway epithelial cells were investigated.	Tetradecanoylphorbol Acetate	187-190	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	65-71
3597558-2	1987	A single treatment with TPA (1 microgram/ml) increased the transcription of c-fos and c-myc proto-oncogenes at least 20-fold in the mortal cell line HU 1752.	Tetradecanoylphorbol Acetate	24-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	86-91
21296386-9	2011	RESULTS: Vitamin E significantly attenuated PMA-induced conformational change of glycoprotein IIb/IIIa and P-selectin expression.	Tetradecanoylphorbol Acetate	44-47	selectin P	Homo sapiens	107-117
3597558-4	1987	When immortalized cell lines were treated with TPA a similar rapid and transient morphological response was observed, but the TPA treatment only increased the level of c-fos mRNA, suggesting that the normal regulation of c-myc transcription is altered in immortalized cells irrespective of their tumorigenic properties.	Tetradecanoylphorbol Acetate	47-50	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	221-226
21216846-4	2011	p-HPEA-EDA inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation of extracellular signal-regulated kinases 1/2 and p90RSK in JB6 Cl41 cells, resulting in the inhibition of cell proliferation, activator protein-1 transactivation and cell transformation promoted by TPA.	Tetradecanoylphorbol Acetate	21-57	ribosomal protein S6 kinase A1	Homo sapiens	138-144
20386016-4	2010	The pharmacodynamics were measured by changes in ERK phosphorylation (pERK) in peripheral blood mononuclear cells, ex vivo stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	137-168	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	70-74
3597558-4	1987	When immortalized cell lines were treated with TPA a similar rapid and transient morphological response was observed, but the TPA treatment only increased the level of c-fos mRNA, suggesting that the normal regulation of c-myc transcription is altered in immortalized cells irrespective of their tumorigenic properties.	Tetradecanoylphorbol Acetate	126-129	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	221-226
20386016-4	2010	The pharmacodynamics were measured by changes in ERK phosphorylation (pERK) in peripheral blood mononuclear cells, ex vivo stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	170-173	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	70-74
21292826-6	2011	The SRF site alone is sufficient for induction by GnRH, whereas induction by 12-tetradecanoylphorbol-13-acetate (TPA) requires both the ELK1 and SRF sites.	Tetradecanoylphorbol Acetate	77-111	ELK1, member of ETS oncogene family	Mus musculus	136-140
3108379-11	1987	The expression of mRNA for c-fos could be readily induced by treatment of macrophages with phorbol myristate acetate (PMA) alone and that for JE by PMA plus the inophore A23187; mRNA for KC was largely unaffected by these agents.	Tetradecanoylphorbol Acetate	91-116	FBJ osteosarcoma oncogene	Mus musculus	27-32
21148409-4	2011	After forskolin stimulation, TPA-induced ubiquitination of AQP2 preceded phosphorylation of AQP2 at S261, which in the first instance occurred predominantly on ubiquitinated AQP2.	Tetradecanoylphorbol Acetate	29-32	aquaporin 2	Canis lupus familiaris	59-63
20554189-0	2010	12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells.	Tetradecanoylphorbol Acetate	0-37	cyclin B1	Homo sapiens	118-127
20554189-0	2010	12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells.	Tetradecanoylphorbol Acetate	0-37	cyclin dependent kinase 1	Homo sapiens	132-136
20554189-0	2010	12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells.	Tetradecanoylphorbol Acetate	0-37	H3 histone pseudogene 16	Homo sapiens	162-165
20554189-0	2010	12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells.	Tetradecanoylphorbol Acetate	39-42	cyclin B1	Homo sapiens	118-127
20554189-0	2010	12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells.	Tetradecanoylphorbol Acetate	39-42	cyclin dependent kinase 1	Homo sapiens	132-136
20554189-0	2010	12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells.	Tetradecanoylphorbol Acetate	39-42	H3 histone pseudogene 16	Homo sapiens	162-165
21148409-4	2011	After forskolin stimulation, TPA-induced ubiquitination of AQP2 preceded phosphorylation of AQP2 at S261, which in the first instance occurred predominantly on ubiquitinated AQP2.	Tetradecanoylphorbol Acetate	29-32	aquaporin 2	Canis lupus familiaris	92-96
3110603-0	1987	Modification of fos proteins: phosphorylation of c-fos, but not v-fos, is stimulated by 12-tetradecanoyl-phorbol-13-acetate and serum.	Tetradecanoylphorbol Acetate	88-123	FBJ osteosarcoma oncogene	Mus musculus	16-19
20554189-6	2010	Under the same conditions, TPA-induced down-regulation of cyclin B1 and cdc2 was decreased by silibinin.	Tetradecanoylphorbol Acetate	27-30	cyclin B1	Homo sapiens	58-67
20554189-6	2010	Under the same conditions, TPA-induced down-regulation of cyclin B1 and cdc2 was decreased by silibinin.	Tetradecanoylphorbol Acetate	27-30	cyclin dependent kinase 1	Homo sapiens	72-76
20554189-7	2010	In contrast, TPA-induced p21 expression was further increased by silibinin.	Tetradecanoylphorbol Acetate	13-16	H3 histone pseudogene 16	Homo sapiens	25-28
3110603-0	1987	Modification of fos proteins: phosphorylation of c-fos, but not v-fos, is stimulated by 12-tetradecanoyl-phorbol-13-acetate and serum.	Tetradecanoylphorbol Acetate	88-123	FBJ osteosarcoma oncogene	Mus musculus	49-54
20554189-10	2010	In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002.	Tetradecanoylphorbol Acetate	13-16	cyclin B1	Homo sapiens	44-53
20967551-11	2011	Those patients showing higher OPN levels before tPA administration displayed a worse prognosis compared to those with lower OPN levels.	Tetradecanoylphorbol Acetate	48-51	secreted phosphoprotein 1	Homo sapiens	30-33
3110603-0	1987	Modification of fos proteins: phosphorylation of c-fos, but not v-fos, is stimulated by 12-tetradecanoyl-phorbol-13-acetate and serum.	Tetradecanoylphorbol Acetate	88-123	FBJ osteosarcoma oncogene	Mus musculus	51-54
20554189-10	2010	In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002.	Tetradecanoylphorbol Acetate	13-16	H3 histone pseudogene 16	Homo sapiens	109-112
2822002-3	1987	Direct activation of the C kinase either by exogenous synthetic diacylglycerol or by 12-O-tetradecanoylphorbol 13-acetate was antagonized by prostaglandin E1 and forskolin.	Tetradecanoylphorbol Acetate	85-121	small nucleolar RNA, H/ACA box 73A	Homo sapiens	155-171
20554189-10	2010	In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002.	Tetradecanoylphorbol Acetate	13-16	H3 histone pseudogene 16	Homo sapiens	150-153
20554189-10	2010	In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002.	Tetradecanoylphorbol Acetate	130-133	cyclin B1	Homo sapiens	44-53
20554189-10	2010	In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002.	Tetradecanoylphorbol Acetate	130-133	H3 histone pseudogene 16	Homo sapiens	109-112
20554189-10	2010	In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002.	Tetradecanoylphorbol Acetate	130-133	cyclin B1	Homo sapiens	44-53
20554189-10	2010	In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002.	Tetradecanoylphorbol Acetate	130-133	H3 histone pseudogene 16	Homo sapiens	109-112
21386996-5	2011	In agreement with previous studies, we demonstrated that PMA triggers a rapid ADAM17-mediated release of HB-EGF.	Tetradecanoylphorbol Acetate	57-60	heparin binding EGF like growth factor	Homo sapiens	105-111
21039753-12	2011	The results of the present study suggest that artemisinin inhibits EMMPRIN and MMP-9 expression and activity by suppressing the PKCdelta/ERK/p38 cascade in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	156-159	basigin (Ok blood group)	Homo sapiens	67-74
3471761-3	1987	When the intact cells were pre-treated with 12-O-tetradecanoylphorbol-13-acetate, the fMLP- and GTP-induced formation of IP2 and IP3 was markedly reduced but the Ca2+-induced reactions were not reduced in the isolated membranes.	Tetradecanoylphorbol Acetate	44-80	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	121-124
21060209-5	2011	The TPA-induced expression of PDGF-B mRNA and PDGF-BB protein levels in culture media was significantly decreased by treatment with PPARalpha activators, Wy14643 and fenofibric acid, in a dose-dependent manner.	Tetradecanoylphorbol Acetate	4-7	peroxisome proliferator activated receptor alpha	Homo sapiens	132-141
20870937-9	2010	In this study, we demonstrate that PMA stimulation led to phosphorylation of NF90 at Ser(647) via PKCbetaI.	Tetradecanoylphorbol Acetate	35-38	interleukin enhancer binding factor 3	Homo sapiens	77-81
20870937-10	2010	This phosphorylation was necessary for nuclear export of NF90 in response to PMA and for IL-2 mRNA stabilization.	Tetradecanoylphorbol Acetate	77-80	interleukin enhancer binding factor 3	Homo sapiens	57-61
20870937-12	2010	Our results support a model in which PMA stimulation activates PKCbetaI to phosphorylate NF90-Ser(647), and this phosphorylation triggers NF90 relocation to the cytoplasm and stabilize IL-2 mRNA.	Tetradecanoylphorbol Acetate	37-40	interleukin enhancer binding factor 3	Homo sapiens	89-93
3494731-3	1987	Here, we demonstrate that the tumor promotor, 12-O-tetradecanoylphorbol-13-acetate (TPA), like EGF, also stimulates receptor synthesis in the human breast carcinoma cell line, MDA468 cells.	Tetradecanoylphorbol Acetate	46-82	epidermal growth factor	Homo sapiens	95-98
20870937-12	2010	Our results support a model in which PMA stimulation activates PKCbetaI to phosphorylate NF90-Ser(647), and this phosphorylation triggers NF90 relocation to the cytoplasm and stabilize IL-2 mRNA.	Tetradecanoylphorbol Acetate	37-40	interleukin enhancer binding factor 3	Homo sapiens	138-142
22257230-2	2011	Together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI-1, PAI-2, PAI-3 and protease nexin), it forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing to the invasive growth and angiogenesis of malignant tumours.	Tetradecanoylphorbol Acetate	53-56	serpin family E member 1	Homo sapiens	84-89
3494731-7	1987	Although TPA treatment resulted in an immediate loss of high affinity EGF-binding sites, the long-term effect was an increase in both the low and high affinity binding sites.	Tetradecanoylphorbol Acetate	9-12	epidermal growth factor	Homo sapiens	70-73
20541543-6	2010	Moreover, palmitate treatment induced activation of protein kinase Ctheta (PKCtheta) while blocking PKCtheta significantly inhibited JNK and IKKbeta activation induced by palmitate or phorbol 12-myristate 13-acetate (PKC activator, PMA), and attenuated the palmitate-induced defects in insulin action.	Tetradecanoylphorbol Acetate	184-215	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	141-148
3494731-10	1987	Nevertheless, the TPA-pretreated cells were still growth-inhibited by EGF.	Tetradecanoylphorbol Acetate	18-21	epidermal growth factor	Homo sapiens	70-73
3112062-1	1987	An attempt was made, by treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), to induce differentiation in Ph1-positive (PB-1049) and Ph1-negative (LN-1049) B lymphoblastoid cell lines established from a patient with chronic myelogenous leukemia, and a Ph1-positive line (PB-1049-T) derived from a tumor nodule formed by inoculation of PB-1049 cells into nude mice.	Tetradecanoylphorbol Acetate	39-76	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	113-116
20529085-6	2010	In contrast, testosterone increased FasL expression dose-dependently in SLE T cells stimulated with PMA plus ionomycin.	Tetradecanoylphorbol Acetate	100-103	Fas ligand	Homo sapiens	36-40
3112062-1	1987	An attempt was made, by treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), to induce differentiation in Ph1-positive (PB-1049) and Ph1-negative (LN-1049) B lymphoblastoid cell lines established from a patient with chronic myelogenous leukemia, and a Ph1-positive line (PB-1049-T) derived from a tumor nodule formed by inoculation of PB-1049 cells into nude mice.	Tetradecanoylphorbol Acetate	39-76	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	140-143
22078535-1	2011	Plasminogen activator inhibitor-1 (PAI-1) belongs to the serine protease inhibitor super family (serpin) and is the primary inhibitor of both the tissue-type (tPA) and urokinase-type (uPA) plasminogen activators.	Tetradecanoylphorbol Acetate	159-162	serpin family E member 1	Homo sapiens	0-33
3112062-1	1987	An attempt was made, by treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), to induce differentiation in Ph1-positive (PB-1049) and Ph1-negative (LN-1049) B lymphoblastoid cell lines established from a patient with chronic myelogenous leukemia, and a Ph1-positive line (PB-1049-T) derived from a tumor nodule formed by inoculation of PB-1049 cells into nude mice.	Tetradecanoylphorbol Acetate	39-76	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	140-143
22078535-1	2011	Plasminogen activator inhibitor-1 (PAI-1) belongs to the serine protease inhibitor super family (serpin) and is the primary inhibitor of both the tissue-type (tPA) and urokinase-type (uPA) plasminogen activators.	Tetradecanoylphorbol Acetate	159-162	serpin family E member 1	Homo sapiens	35-40
20690147-5	2010	Over 14 000 highly confident in vivo EGR1 binding sites were identified in phorbol 12-myristate 13-acetate-treated K562 cells.	Tetradecanoylphorbol Acetate	75-106	early growth response 1	Homo sapiens	37-41
3112062-1	1987	An attempt was made, by treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), to induce differentiation in Ph1-positive (PB-1049) and Ph1-negative (LN-1049) B lymphoblastoid cell lines established from a patient with chronic myelogenous leukemia, and a Ph1-positive line (PB-1049-T) derived from a tumor nodule formed by inoculation of PB-1049 cells into nude mice.	Tetradecanoylphorbol Acetate	78-81	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	113-116
3112062-1	1987	An attempt was made, by treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), to induce differentiation in Ph1-positive (PB-1049) and Ph1-negative (LN-1049) B lymphoblastoid cell lines established from a patient with chronic myelogenous leukemia, and a Ph1-positive line (PB-1049-T) derived from a tumor nodule formed by inoculation of PB-1049 cells into nude mice.	Tetradecanoylphorbol Acetate	78-81	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	140-143
21220488-7	2011	PMA-induced skin carcinogenesis in RLIP76(+/+) mouse was suppressed completely by depletion of either PKCalpha or RLIP76 by siRNA or antisense and could be restored by topical application of RLIP76 protein in RLIP76(-/-) mouse skin.	Tetradecanoylphorbol Acetate	0-3	ralA binding protein 1	Mus musculus	35-41
3112062-1	1987	An attempt was made, by treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), to induce differentiation in Ph1-positive (PB-1049) and Ph1-negative (LN-1049) B lymphoblastoid cell lines established from a patient with chronic myelogenous leukemia, and a Ph1-positive line (PB-1049-T) derived from a tumor nodule formed by inoculation of PB-1049 cells into nude mice.	Tetradecanoylphorbol Acetate	78-81	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	140-143
21220488-7	2011	PMA-induced skin carcinogenesis in RLIP76(+/+) mouse was suppressed completely by depletion of either PKCalpha or RLIP76 by siRNA or antisense and could be restored by topical application of RLIP76 protein in RLIP76(-/-) mouse skin.	Tetradecanoylphorbol Acetate	0-3	ralA binding protein 1	Mus musculus	114-120
21220488-7	2011	PMA-induced skin carcinogenesis in RLIP76(+/+) mouse was suppressed completely by depletion of either PKCalpha or RLIP76 by siRNA or antisense and could be restored by topical application of RLIP76 protein in RLIP76(-/-) mouse skin.	Tetradecanoylphorbol Acetate	0-3	ralA binding protein 1	Mus musculus	114-120
20441787-0	2010	Characterization of the promoter region of the human IGHMBP2 (Smubp-2) gene and its response to TPA in HL-60 cells.	Tetradecanoylphorbol Acetate	96-99	immunoglobulin mu DNA binding protein 2	Homo sapiens	53-60
20441787-0	2010	Characterization of the promoter region of the human IGHMBP2 (Smubp-2) gene and its response to TPA in HL-60 cells.	Tetradecanoylphorbol Acetate	96-99	immunoglobulin mu DNA binding protein 2	Homo sapiens	62-69
3571335-2	1987	After 2 h from the initial treatment, c-fos mRNA could no longer be detected and its expression could not be restimulated either by LPS or by other signals including colony stimulating factor-1 (CSF-1) and phorbol myristate acetate (PMA), both of which are able to induce expression of the c-fos gene in unstimulated macrophages.	Tetradecanoylphorbol Acetate	233-236	FBJ osteosarcoma oncogene	Mus musculus	38-43
20441787-8	2010	Moreover, co-transfection of the PU.1 expression plasmid and pSmu-Luc into HL-60 cells revealed that PU.1 modulates TPA-induced IGHMBP2 promoter activity.	Tetradecanoylphorbol Acetate	116-119	Spi-1 proto-oncogene	Homo sapiens	33-37
20441787-8	2010	Moreover, co-transfection of the PU.1 expression plasmid and pSmu-Luc into HL-60 cells revealed that PU.1 modulates TPA-induced IGHMBP2 promoter activity.	Tetradecanoylphorbol Acetate	116-119	Spi-1 proto-oncogene	Homo sapiens	101-105
20441787-8	2010	Moreover, co-transfection of the PU.1 expression plasmid and pSmu-Luc into HL-60 cells revealed that PU.1 modulates TPA-induced IGHMBP2 promoter activity.	Tetradecanoylphorbol Acetate	116-119	immunoglobulin mu DNA binding protein 2	Homo sapiens	128-135
20441787-9	2010	Taken together, these observations suggest that the duplicated GGAA motifs are essential for the IGHMBP2 promoter activity and its positive response to TPA in HL-60 cells.	Tetradecanoylphorbol Acetate	152-155	immunoglobulin mu DNA binding protein 2	Homo sapiens	97-104
21220488-7	2011	PMA-induced skin carcinogenesis in RLIP76(+/+) mouse was suppressed completely by depletion of either PKCalpha or RLIP76 by siRNA or antisense and could be restored by topical application of RLIP76 protein in RLIP76(-/-) mouse skin.	Tetradecanoylphorbol Acetate	0-3	ralA binding protein 1	Mus musculus	114-120
22812190-0	2011	Inhibition of SPHK1 suppresses phorbol 12-myristate 13-acetate-induced metastatic phenotype in colorectal cancer HT-29 cells.	Tetradecanoylphorbol Acetate	31-62	sphingosine kinase 1	Homo sapiens	14-19
2435814-5	1987	However, both normal EC and A 431 cells produced increased levels of EC IL-3 activity when cultured in the presence of different stimulants, such as phorbol myristate acetate and lipopolysaccharide.	Tetradecanoylphorbol Acetate	149-174	interleukin 3	Homo sapiens	72-76
22812190-6	2011	PMA induced a metastatic phenotype in colorectal cancer cells, as indicated by cell viability, migration and invasion capacity, and ERK1/2 phosphorylation, whereas SPHK1 siRNA transfection suppressed the metastatic phenotype of tumor cells and antagonized PMA"s effects.	Tetradecanoylphorbol Acetate	256-259	sphingosine kinase 1	Homo sapiens	164-169
22812190-8	2011	Suppression of SPHK1 expression suppresses the PMA-induced metastatic phenotype via ERK1/2 phosphorylation in human colorectal cancer cells.	Tetradecanoylphorbol Acetate	47-50	sphingosine kinase 1	Homo sapiens	15-20
21858203-2	2011	Interaction of urokinase-type plasminogen activator (uPA) with its cell surface receptor (uPAR) has been shown to favor virion accumulation in such sub-cellular compartment in primary monocyte-derived macrophages and chronically infected promonocytic U1 cells differentiated into macrophage-like cells by stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	322-347	plasminogen activator, urokinase receptor	Homo sapiens	90-94
20504934-3	2010	In this model, we show that phorbol 12-myristate 13-acetate (PMA) immediately activates the expression of HCMV MIE RNA and protein and greatly increases the MIE-positive (MIE(+)) NT2 cell population density; levels of Oct4 (pluripotent cell marker) and HCMV genome penetration are unchanged.	Tetradecanoylphorbol Acetate	28-59	POU class 5 homeobox 1	Homo sapiens	218-222
20504934-3	2010	In this model, we show that phorbol 12-myristate 13-acetate (PMA) immediately activates the expression of HCMV MIE RNA and protein and greatly increases the MIE-positive (MIE(+)) NT2 cell population density; levels of Oct4 (pluripotent cell marker) and HCMV genome penetration are unchanged.	Tetradecanoylphorbol Acetate	61-64	POU class 5 homeobox 1	Homo sapiens	218-222
20682802-5	2010	GW2974 effectively inhibited skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in wild-type and BK5.erbB2 mice, although a more marked effect was seen in BK5.erbB2 mice.	Tetradecanoylphorbol Acetate	53-89	erb-b2 receptor tyrosine kinase 2	Mus musculus	111-116
3494448-2	1987	In cultured porcine thyroid cells, EGF and TPA stimulate PGE2 and 6-keto PGF1 alpha production; the maximum PG levels were obtained after 3-4 h incubation with EGF or TPA; the addition of as little as 10(-11) M EGF or 5 X 10(-11) M TPA resulted in increases in PGE2 and 6-keto PGF1 alpha, and the maximum levels were obtained with 10(-8)-10(-7) M EGF or TPA.	Tetradecanoylphorbol Acetate	43-46	epidermal growth factor	Homo sapiens	160-163
20682802-7	2010	GW2974 inhibited 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperproliferation, which correlated with reduced activation of both the EGFR and erbB2.	Tetradecanoylphorbol Acetate	17-53	epidermal growth factor receptor	Mus musculus	145-149
20682802-7	2010	GW2974 inhibited 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperproliferation, which correlated with reduced activation of both the EGFR and erbB2.	Tetradecanoylphorbol Acetate	17-53	erb-b2 receptor tyrosine kinase 2	Mus musculus	154-159
20479004-7	2010	Silencing of Pin1 expression inhibited TPA-induced MEK1/2 phosphorylation in MCF7 cells.	Tetradecanoylphorbol Acetate	39-42	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	13-17
20479004-7	2010	Silencing of Pin1 expression inhibited TPA-induced MEK1/2 phosphorylation in MCF7 cells.	Tetradecanoylphorbol Acetate	39-42	mitogen-activated protein kinase kinase 1	Homo sapiens	51-57
21858203-2	2011	Interaction of urokinase-type plasminogen activator (uPA) with its cell surface receptor (uPAR) has been shown to favor virion accumulation in such sub-cellular compartment in primary monocyte-derived macrophages and chronically infected promonocytic U1 cells differentiated into macrophage-like cells by stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	349-352	CD177 molecule	Homo sapiens	67-88
21858203-2	2011	Interaction of urokinase-type plasminogen activator (uPA) with its cell surface receptor (uPAR) has been shown to favor virion accumulation in such sub-cellular compartment in primary monocyte-derived macrophages and chronically infected promonocytic U1 cells differentiated into macrophage-like cells by stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	349-352	plasminogen activator, urokinase receptor	Homo sapiens	90-94
20479004-8	2010	Moreover, PD98059, a specific inhibitor of MEK1/2, and juglone, a potent Pin1 inhibitor, significantly suppressed the TPA-induced expression of E2F-4 as well as Egr-1 transcription factors, which control LC-3 gene expression.	Tetradecanoylphorbol Acetate	118-121	mitogen-activated protein kinase kinase 1	Homo sapiens	43-49
3494448-2	1987	In cultured porcine thyroid cells, EGF and TPA stimulate PGE2 and 6-keto PGF1 alpha production; the maximum PG levels were obtained after 3-4 h incubation with EGF or TPA; the addition of as little as 10(-11) M EGF or 5 X 10(-11) M TPA resulted in increases in PGE2 and 6-keto PGF1 alpha, and the maximum levels were obtained with 10(-8)-10(-7) M EGF or TPA.	Tetradecanoylphorbol Acetate	43-46	epidermal growth factor	Homo sapiens	160-163
20479004-8	2010	Moreover, PD98059, a specific inhibitor of MEK1/2, and juglone, a potent Pin1 inhibitor, significantly suppressed the TPA-induced expression of E2F-4 as well as Egr-1 transcription factors, which control LC-3 gene expression.	Tetradecanoylphorbol Acetate	118-121	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	73-77
20728597-7	2010	Interestingly, maximal IL-2 production and CD4(+) T cell cycle progression are observed upon activation with soluble anti-CD3 and phorbol 12-myristate 13-acetate (PMA), a phorbol ester.	Tetradecanoylphorbol Acetate	130-161	interleukin 2	Mus musculus	23-27
3494448-2	1987	In cultured porcine thyroid cells, EGF and TPA stimulate PGE2 and 6-keto PGF1 alpha production; the maximum PG levels were obtained after 3-4 h incubation with EGF or TPA; the addition of as little as 10(-11) M EGF or 5 X 10(-11) M TPA resulted in increases in PGE2 and 6-keto PGF1 alpha, and the maximum levels were obtained with 10(-8)-10(-7) M EGF or TPA.	Tetradecanoylphorbol Acetate	43-46	epidermal growth factor	Homo sapiens	160-163
20728597-7	2010	Interestingly, maximal IL-2 production and CD4(+) T cell cycle progression are observed upon activation with soluble anti-CD3 and phorbol 12-myristate 13-acetate (PMA), a phorbol ester.	Tetradecanoylphorbol Acetate	163-166	interleukin 2	Mus musculus	23-27
3494448-2	1987	In cultured porcine thyroid cells, EGF and TPA stimulate PGE2 and 6-keto PGF1 alpha production; the maximum PG levels were obtained after 3-4 h incubation with EGF or TPA; the addition of as little as 10(-11) M EGF or 5 X 10(-11) M TPA resulted in increases in PGE2 and 6-keto PGF1 alpha, and the maximum levels were obtained with 10(-8)-10(-7) M EGF or TPA.	Tetradecanoylphorbol Acetate	167-170	epidermal growth factor	Homo sapiens	35-38
20558134-7	2010	The stimulation of cells by PMA (1 microM, 6 h) significantly increased the ECE-1 activity (0.28+/-0.02; n=3) compared to the control (0.07+/-0.02; n=3).	Tetradecanoylphorbol Acetate	28-31	endothelin converting enzyme 1	Homo sapiens	76-81
3494448-2	1987	In cultured porcine thyroid cells, EGF and TPA stimulate PGE2 and 6-keto PGF1 alpha production; the maximum PG levels were obtained after 3-4 h incubation with EGF or TPA; the addition of as little as 10(-11) M EGF or 5 X 10(-11) M TPA resulted in increases in PGE2 and 6-keto PGF1 alpha, and the maximum levels were obtained with 10(-8)-10(-7) M EGF or TPA.	Tetradecanoylphorbol Acetate	167-170	epidermal growth factor	Homo sapiens	35-38
20558134-9	2010	Treatment with PMA also increased the activity of ECE-1 in the media (0.18+/-0.01; n=3) compared to control (0.08+/-0.01; n=3).	Tetradecanoylphorbol Acetate	15-18	endothelin converting enzyme 1	Homo sapiens	50-55
3494448-2	1987	In cultured porcine thyroid cells, EGF and TPA stimulate PGE2 and 6-keto PGF1 alpha production; the maximum PG levels were obtained after 3-4 h incubation with EGF or TPA; the addition of as little as 10(-11) M EGF or 5 X 10(-11) M TPA resulted in increases in PGE2 and 6-keto PGF1 alpha, and the maximum levels were obtained with 10(-8)-10(-7) M EGF or TPA.	Tetradecanoylphorbol Acetate	167-170	epidermal growth factor	Homo sapiens	35-38
3109389-1	1987	The effects of thyrotropin-releasing hormone (TRH) and 12-O-tetradecanoylphorbol 13-acetate (TPA) on cytosolic pH (pHi) were studied on GH4C1 pituitary cells loaded with the fluorescent pH indicator bis(carboxyethyl)carboxyfluorescein (BCECF) and the fluorescent Ca2+ indicator quin2.	Tetradecanoylphorbol Acetate	55-91	glucose-6-phosphate isomerase	Rattus norvegicus	115-118
20230530-3	2010	When cells were treated with phorbol 12-myristate 13-acetate (PMA), RNF13 avoided proteolysis.	Tetradecanoylphorbol Acetate	29-60	ring finger protein 13	Homo sapiens	68-73
20861213-2	2010	Enterocytic expression of the transcriptional coregulator tetradecanoyl phorbol acetate induced sequence 7 (Tis7) is markedly increased in a murine model of intestinal adaptation.	Tetradecanoylphorbol Acetate	58-87	interferon-related developmental regulator 1	Mus musculus	108-112
20709134-1	2010	This study investigated the preventive effect of ribosomal protein S3 (rpS3) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice.	Tetradecanoylphorbol Acetate	118-121	ribosomal protein S3	Mus musculus	49-69
20709134-1	2010	This study investigated the preventive effect of ribosomal protein S3 (rpS3) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice.	Tetradecanoylphorbol Acetate	118-121	ribosomal protein S3	Mus musculus	71-75
20709134-4	2010	Application of PEP-1-rpS3 also resulted in a significant reduction in the activation of nuclear factor-kappa B (NF-kB) and mitogen-activated protein kinase (MAPK) in TPA-treated ears.	Tetradecanoylphorbol Acetate	166-169	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	15-20
20709134-4	2010	Application of PEP-1-rpS3 also resulted in a significant reduction in the activation of nuclear factor-kappa B (NF-kB) and mitogen-activated protein kinase (MAPK) in TPA-treated ears.	Tetradecanoylphorbol Acetate	166-169	ribosomal protein S3	Mus musculus	21-25
20599951-6	2010	Importantly, treatment of human dermal microvascular endothelial cells with tumor necrosis factor or phorbol 12-myristate 13-acetate resulted in Thy1 upregulation in podoplanin-expressing lymphatic endothelial cells, but not in podoplanin-negative blood vascular endothelial cells.	Tetradecanoylphorbol Acetate	101-132	Thy-1 cell surface antigen	Homo sapiens	145-149
20726989-10	2010	Upon stimulation with phorbol myristate acetate plus ionomycin, splenocytes from alpha-GalCer-treated mice produced significantly more cytokines [including IFN-gamma, tumour necrosis factor-alpha, IL-4 and IL-10] than those from untreated mice.	Tetradecanoylphorbol Acetate	22-47	interleukin 4	Mus musculus	197-201
20660715-7	2010	Capsaicin induced a further induction of TPA-increased COX-2 expression in EGFR/WT cells, but not in EGFR/KO cells.	Tetradecanoylphorbol Acetate	41-44	epidermal growth factor receptor	Mus musculus	75-79
20660715-8	2010	TPA/capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR/WT, but not EGFR/KO cells.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor receptor	Mus musculus	33-37
20660715-8	2010	TPA/capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR/WT, but not EGFR/KO cells.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor receptor	Mus musculus	77-81
20660715-8	2010	TPA/capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR/WT, but not EGFR/KO cells.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor receptor	Mus musculus	77-81
20660715-8	2010	TPA/capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR/WT, but not EGFR/KO cells.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor receptor	Mus musculus	77-81
20660715-10	2010	Together, these findings suggest that capsaicin might act as a cocarcinogen in TPA-induced skin carcinogenesis through EGFR-dependent mechanisms.	Tetradecanoylphorbol Acetate	79-82	epidermal growth factor receptor	Mus musculus	119-123
20336681-5	2010	6-Shogaol also reduced TPA-induced phosphorylation of IkappaBalpha and p65, and caused subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	23-26	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	71-74
20558593-8	2010	In addition, LPS or phorbol 12-myristate 13-acetate stimulated PLD activity, and the pretreatment of PLD inhibitor weakened foam cell formation and recovered RGS2 down-regulation.	Tetradecanoylphorbol Acetate	20-51	regulator of G-protein signaling 2	Mus musculus	158-162
20512034-11	2010	Phosphorylation levels induced by interleukin-6 in STAT1 and STAT3 and by combination of phorbol 12-myristate 13-acetate and calcium ionophore A23187 in extracellular signal-regulated kinases 1/2, members of a mitogen-activated protein kinase family, were depressed in patients" monocytes, whereas phosphorylation levels induced by granulocyte-macrophage colony-stimulating factor in STAT5 was normal.	Tetradecanoylphorbol Acetate	89-120	colony stimulating factor 2	Homo sapiens	332-380
20512034-11	2010	Phosphorylation levels induced by interleukin-6 in STAT1 and STAT3 and by combination of phorbol 12-myristate 13-acetate and calcium ionophore A23187 in extracellular signal-regulated kinases 1/2, members of a mitogen-activated protein kinase family, were depressed in patients" monocytes, whereas phosphorylation levels induced by granulocyte-macrophage colony-stimulating factor in STAT5 was normal.	Tetradecanoylphorbol Acetate	89-120	signal transducer and activator of transcription 5A	Homo sapiens	384-389
20448034-5	2010	Phorbol 12-myristate 13-acetate-, thrombin-, or forskolin-induced von Willebrand factor release or translocation of P-selectin from endothelial cells were inhibited by alpha- and beta-synuclein but not gamma-synuclein.	Tetradecanoylphorbol Acetate	0-31	selectin P	Homo sapiens	116-126
20448034-5	2010	Phorbol 12-myristate 13-acetate-, thrombin-, or forskolin-induced von Willebrand factor release or translocation of P-selectin from endothelial cells were inhibited by alpha- and beta-synuclein but not gamma-synuclein.	Tetradecanoylphorbol Acetate	0-31	synuclein alpha	Homo sapiens	179-193
20226564-6	2010	The expression of HOPX was induced through the phorbol-12-myristate-13-acetate (PMA)-dependent protein kinase C (PKC) signaling pathway, and not by the demethylating agent, 5-aza-dC (5-aza-2"-deoxycitidine) suggesting the suppression of HOPX is not associated with DNA methylation in human keratinocytes.	Tetradecanoylphorbol Acetate	47-78	HOP homeobox	Homo sapiens	18-22
20226564-6	2010	The expression of HOPX was induced through the phorbol-12-myristate-13-acetate (PMA)-dependent protein kinase C (PKC) signaling pathway, and not by the demethylating agent, 5-aza-dC (5-aza-2"-deoxycitidine) suggesting the suppression of HOPX is not associated with DNA methylation in human keratinocytes.	Tetradecanoylphorbol Acetate	80-83	HOP homeobox	Homo sapiens	18-22
20298789-10	2010	IRF8 expression in stimulated trout splenocytes was significantly up-regulated by polyinosinic:polycytidylic acid (poly I:C), trout recombinant (r)IL-15, phorbol 12-myristate 13-acetate (PMA), and phytohaemagglutinin (PHA) treatment whilst remaining refractory towards lipopolysaccharide (LPS) treatment.	Tetradecanoylphorbol Acetate	154-185	interferon regulatory factor 8	Homo sapiens	0-4
20298789-10	2010	IRF8 expression in stimulated trout splenocytes was significantly up-regulated by polyinosinic:polycytidylic acid (poly I:C), trout recombinant (r)IL-15, phorbol 12-myristate 13-acetate (PMA), and phytohaemagglutinin (PHA) treatment whilst remaining refractory towards lipopolysaccharide (LPS) treatment.	Tetradecanoylphorbol Acetate	187-190	interferon regulatory factor 8	Homo sapiens	0-4
20339915-7	2010	In addition, phorbol-12-myristate-13-acetate, an activator of PKC, up-regulated c-gelsolin expression.	Tetradecanoylphorbol Acetate	13-44	gelsolin	Homo sapiens	82-90
20232358-0	2010	Dietary energy restriction, in part through glucocorticoid hormones, mediates the impact of 12-O-tetradecanoylphorbol-13-acetate on jun D and fra-1 in Sencar mouse epidermis.	Tetradecanoylphorbol Acetate	92-128	jun D proto-oncogene	Mus musculus	132-137
20232358-0	2010	Dietary energy restriction, in part through glucocorticoid hormones, mediates the impact of 12-O-tetradecanoylphorbol-13-acetate on jun D and fra-1 in Sencar mouse epidermis.	Tetradecanoylphorbol Acetate	92-128	fos-like antigen 1	Mus musculus	142-147
20232358-3	2010	TPA significantly increased c-jun, jun B, c-fos, fra-1, and fra-2 and decreased jun D within 3-6 h after treatment.	Tetradecanoylphorbol Acetate	0-3	jun B proto-oncogene	Mus musculus	35-40
20232358-3	2010	TPA significantly increased c-jun, jun B, c-fos, fra-1, and fra-2 and decreased jun D within 3-6 h after treatment.	Tetradecanoylphorbol Acetate	0-3	FBJ osteosarcoma oncogene	Mus musculus	42-47
20232358-3	2010	TPA significantly increased c-jun, jun B, c-fos, fra-1, and fra-2 and decreased jun D within 3-6 h after treatment.	Tetradecanoylphorbol Acetate	0-3	fos-like antigen 1	Mus musculus	49-54
20232358-3	2010	TPA significantly increased c-jun, jun B, c-fos, fra-1, and fra-2 and decreased jun D within 3-6 h after treatment.	Tetradecanoylphorbol Acetate	0-3	fos-like antigen 2	Mus musculus	60-65
20232358-3	2010	TPA significantly increased c-jun, jun B, c-fos, fra-1, and fra-2 and decreased jun D within 3-6 h after treatment.	Tetradecanoylphorbol Acetate	0-3	jun D proto-oncogene	Mus musculus	80-85
20232358-4	2010	AP-1:DNA binding reached a maximum 2.5-fold induction over controls 4 h after TPA treatment and antibodies to jun B, jun D, and fra-2 in the EMSA binding reaction resulted in supershifts in both acetone- and TPA-treated mice 1-6 h after treatment.	Tetradecanoylphorbol Acetate	208-211	jun B proto-oncogene	Mus musculus	110-115
20232358-4	2010	AP-1:DNA binding reached a maximum 2.5-fold induction over controls 4 h after TPA treatment and antibodies to jun B, jun D, and fra-2 in the EMSA binding reaction resulted in supershifts in both acetone- and TPA-treated mice 1-6 h after treatment.	Tetradecanoylphorbol Acetate	208-211	jun D proto-oncogene	Mus musculus	117-122
20232358-4	2010	AP-1:DNA binding reached a maximum 2.5-fold induction over controls 4 h after TPA treatment and antibodies to jun B, jun D, and fra-2 in the EMSA binding reaction resulted in supershifts in both acetone- and TPA-treated mice 1-6 h after treatment.	Tetradecanoylphorbol Acetate	208-211	fos-like antigen 2	Mus musculus	128-133
20232358-6	2010	DER reduced the TPA impact on jun D and enhanced the induction of fra-1.	Tetradecanoylphorbol Acetate	16-19	jun D proto-oncogene	Mus musculus	30-35
20232358-8	2010	While sham animals treated with either acetone or TPA contained jun B, jun D, and fra-2 proteins in the AP-1:DNA complex by supershift analysis, fra-2 was no longer seen in adx DER animals.	Tetradecanoylphorbol Acetate	50-53	jun B proto-oncogene	Mus musculus	64-69
20232358-8	2010	While sham animals treated with either acetone or TPA contained jun B, jun D, and fra-2 proteins in the AP-1:DNA complex by supershift analysis, fra-2 was no longer seen in adx DER animals.	Tetradecanoylphorbol Acetate	50-53	jun D proto-oncogene	Mus musculus	71-76
20232358-8	2010	While sham animals treated with either acetone or TPA contained jun B, jun D, and fra-2 proteins in the AP-1:DNA complex by supershift analysis, fra-2 was no longer seen in adx DER animals.	Tetradecanoylphorbol Acetate	50-53	fos-like antigen 2	Mus musculus	82-87
20299489-9	2010	Taken together, the results show that PMA activates the MEK-ERK pathway and strongly induces miRNA-34a expression, which in turn inhibits cell proliferation by repressing the expression of MEK1.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase kinase 1	Homo sapiens	189-193
20218615-4	2010	Pretreatment with magnolol resulted in the reduction of TPA-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunit and DNA binding by blocking the phosphorylation of IkappaBalpha and p65 and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	56-59	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	206-209
20223829-5	2010	We characterized S-glutathionylation of A9; GSSG and GSNO generated S-glutathionylated A8 (A8-SSG) and A9 (A9-SSG) in vitro, whereas only A9-SSG was detected in cytosol of neutrophils activated with phorbol myristate acetate (PMA) but not with fMLP or opsonized zymosan.	Tetradecanoylphorbol Acetate	199-224	UDP glucuronosyltransferase 1 family, polypeptide A6B	Mus musculus	40-42
20223829-5	2010	We characterized S-glutathionylation of A9; GSSG and GSNO generated S-glutathionylated A8 (A8-SSG) and A9 (A9-SSG) in vitro, whereas only A9-SSG was detected in cytosol of neutrophils activated with phorbol myristate acetate (PMA) but not with fMLP or opsonized zymosan.	Tetradecanoylphorbol Acetate	199-224	brain protein 8	Mus musculus	87-89
20491082-3	2010	CT1 and CT2 showed very strong anti-tumor-promoting activities at IC(50) 0.7 microg/ml and 0.1 microg/ml, respectively, in a convenient, short-term in vitro assay, i.e., the inhibition of Epstein-Barr virus (EBV) activation induced by phorbol 12-myristate 13-acetate (PMA) and sodium butyrate.	Tetradecanoylphorbol Acetate	235-266	cardiotrophin 1	Homo sapiens	0-3
20491082-3	2010	CT1 and CT2 showed very strong anti-tumor-promoting activities at IC(50) 0.7 microg/ml and 0.1 microg/ml, respectively, in a convenient, short-term in vitro assay, i.e., the inhibition of Epstein-Barr virus (EBV) activation induced by phorbol 12-myristate 13-acetate (PMA) and sodium butyrate.	Tetradecanoylphorbol Acetate	268-271	cardiotrophin 1	Homo sapiens	0-3
20159975-4	2010	PKC activation by the phorbol ester (phorbol 12-myristate 13-acetate, PMA) resulted in increased phosphorylation of OATP2B1 as well as reduced OATP2B1 transport activity with a decrease in V(max) of E(1)S uptake (288 +/- 21 (control) versus 165 +/- 16 pmol/min/mg of protein (PMA)).	Tetradecanoylphorbol Acetate	37-68	solute carrier organic anion transporter family member 2B1	Homo sapiens	116-123
20159975-4	2010	PKC activation by the phorbol ester (phorbol 12-myristate 13-acetate, PMA) resulted in increased phosphorylation of OATP2B1 as well as reduced OATP2B1 transport activity with a decrease in V(max) of E(1)S uptake (288 +/- 21 (control) versus 165 +/- 16 pmol/min/mg of protein (PMA)).	Tetradecanoylphorbol Acetate	37-68	solute carrier organic anion transporter family member 2B1	Homo sapiens	143-150
20006981-5	2010	The PKCalpha activator, phorbol-12-myristate-13-acetate (PMA) induced the expression of VDR in the rat liver, and the induction of VDR by 1,25(OH)(2)D(3) and CDCA was inhibited by the PKCalpha inhibitor, bisindolyl maleimide I (Bis I).	Tetradecanoylphorbol Acetate	24-55	vitamin D receptor	Rattus norvegicus	88-91
20006981-5	2010	The PKCalpha activator, phorbol-12-myristate-13-acetate (PMA) induced the expression of VDR in the rat liver, and the induction of VDR by 1,25(OH)(2)D(3) and CDCA was inhibited by the PKCalpha inhibitor, bisindolyl maleimide I (Bis I).	Tetradecanoylphorbol Acetate	24-55	vitamin D receptor	Rattus norvegicus	131-134
20006981-5	2010	The PKCalpha activator, phorbol-12-myristate-13-acetate (PMA) induced the expression of VDR in the rat liver, and the induction of VDR by 1,25(OH)(2)D(3) and CDCA was inhibited by the PKCalpha inhibitor, bisindolyl maleimide I (Bis I).	Tetradecanoylphorbol Acetate	57-60	vitamin D receptor	Rattus norvegicus	88-91
20006981-5	2010	The PKCalpha activator, phorbol-12-myristate-13-acetate (PMA) induced the expression of VDR in the rat liver, and the induction of VDR by 1,25(OH)(2)D(3) and CDCA was inhibited by the PKCalpha inhibitor, bisindolyl maleimide I (Bis I).	Tetradecanoylphorbol Acetate	57-60	vitamin D receptor	Rattus norvegicus	131-134
20004183-0	2010	Purification of a peptide from seahorse, that inhibits TPA-induced MMP, iNOS and COX-2 expression through MAPK and NF-kappaB activation, and induces human osteoblastic and chondrocytic differentiation.	Tetradecanoylphorbol Acetate	55-58	inositol-3-phosphate synthase 1	Homo sapiens	72-76
20139271-5	2010	Stimulation with PMA/ionomycin caused splenic CD4(+)PD-1(+) T cells to secrete high levels of IFN-gamma, IL-10, low levels of TNF-alpha, faint levels of IL-2, IL-21, and no IL-4, IL-17.	Tetradecanoylphorbol Acetate	17-20	interleukin-17A	Sus scrofa	179-184
20018888-0	2010	Overcoming amino-Nogo-induced inhibition of cell spreading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters.	Tetradecanoylphorbol Acetate	84-120	reticulon 4	Homo sapiens	17-21
20018888-3	2010	12-O-Tetradecanoylphorbol-13-acetate-type tumor promoters, such as phorbol 12-myristate 13-acetate (PMA) and teleocidin, increase Rac1 activity and overcome the amino-Nogo-induced inhibition of cell spreading.	Tetradecanoylphorbol Acetate	0-36	reticulon 4	Homo sapiens	167-171
20018888-3	2010	12-O-Tetradecanoylphorbol-13-acetate-type tumor promoters, such as phorbol 12-myristate 13-acetate (PMA) and teleocidin, increase Rac1 activity and overcome the amino-Nogo-induced inhibition of cell spreading.	Tetradecanoylphorbol Acetate	67-98	reticulon 4	Homo sapiens	167-171
20018888-3	2010	12-O-Tetradecanoylphorbol-13-acetate-type tumor promoters, such as phorbol 12-myristate 13-acetate (PMA) and teleocidin, increase Rac1 activity and overcome the amino-Nogo-induced inhibition of cell spreading.	Tetradecanoylphorbol Acetate	100-103	reticulon 4	Homo sapiens	167-171
20025870-7	2010	In contrast, treatment of HASM by PMA induces phosphorylation and activation of Ra, MEK1/2, ERK1/2, JNK, Elk-1, and c-Jun.	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase kinase 1	Homo sapiens	84-90
20930381-4	2010	Expression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-7 (MMP-7) in hepatoma cells was inhibited by isofraxidin at the both mRNA and protein levels.	Tetradecanoylphorbol Acetate	14-50	matrix metallopeptidase 7	Homo sapiens	65-91
20930381-4	2010	Expression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-7 (MMP-7) in hepatoma cells was inhibited by isofraxidin at the both mRNA and protein levels.	Tetradecanoylphorbol Acetate	14-50	matrix metallopeptidase 7	Homo sapiens	93-98
20930381-4	2010	Expression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-7 (MMP-7) in hepatoma cells was inhibited by isofraxidin at the both mRNA and protein levels.	Tetradecanoylphorbol Acetate	52-55	matrix metallopeptidase 7	Homo sapiens	65-91
20930381-4	2010	Expression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-7 (MMP-7) in hepatoma cells was inhibited by isofraxidin at the both mRNA and protein levels.	Tetradecanoylphorbol Acetate	52-55	matrix metallopeptidase 7	Homo sapiens	93-98
19913583-5	2010	In native SH-SY5Y neuroblastoma cells, PKC activation with phorbol 12-myristate 13-acetate (PMA, 16 nM, 24h) down-regulated hMOR transcription and concomitantly elevated the REST binding activity to repressor element 1 of the hMOR promoter.	Tetradecanoylphorbol Acetate	59-90	opioid receptor mu 1	Homo sapiens	124-128
19913583-5	2010	In native SH-SY5Y neuroblastoma cells, PKC activation with phorbol 12-myristate 13-acetate (PMA, 16 nM, 24h) down-regulated hMOR transcription and concomitantly elevated the REST binding activity to repressor element 1 of the hMOR promoter.	Tetradecanoylphorbol Acetate	59-90	opioid receptor mu 1	Homo sapiens	226-230
19913583-5	2010	In native SH-SY5Y neuroblastoma cells, PKC activation with phorbol 12-myristate 13-acetate (PMA, 16 nM, 24h) down-regulated hMOR transcription and concomitantly elevated the REST binding activity to repressor element 1 of the hMOR promoter.	Tetradecanoylphorbol Acetate	92-95	opioid receptor mu 1	Homo sapiens	124-128
19913583-5	2010	In native SH-SY5Y neuroblastoma cells, PKC activation with phorbol 12-myristate 13-acetate (PMA, 16 nM, 24h) down-regulated hMOR transcription and concomitantly elevated the REST binding activity to repressor element 1 of the hMOR promoter.	Tetradecanoylphorbol Acetate	92-95	opioid receptor mu 1	Homo sapiens	226-230
20011019-4	2009	Measured two photon absorption (TPA) coefficients are beta=1x10(-4) cm/W (LaF(3)), 1.8x10(-5), and 5.8x10(-5) cm/W (MgF(2)).	Tetradecanoylphorbol Acetate	32-35	signal transducer and activator of transcription 5A	Homo sapiens	116-119
19808857-7	2009	This was further supported by: (i) increased levels of the tumor suppressor protein p53 in MK2(-/-) mice after DMBA/TPA treatment compared with controls, (ii) reduced phosphorylation (activation) of the negative p53 regulator, murine double minute 2 in MK2(-)(/-) mouse keratinocytes in vitro and (iii) a significant decrease in the DMBA/TPA induced apoptosis in cultured MK2(-/-) keratinocytes transfected with p53 small interfering RNA.	Tetradecanoylphorbol Acetate	116-119	transformation related protein 53, pseudogene	Mus musculus	84-87
19855090-3	2009	In contrast, we show here that in these and other cells, IGF-IR overexpression reduced the constitutive and phorbol 12-myristate 13-acetate (PMA)-inducible expression of three protein kinase C (PKC)-regulated metalloproteinases, MMP-3, MMP-9, and MMP-13, in cultured cells as well as in vivo in sc tumors.	Tetradecanoylphorbol Acetate	108-139	matrix metallopeptidase 3	Mus musculus	229-234
19855090-3	2009	In contrast, we show here that in these and other cells, IGF-IR overexpression reduced the constitutive and phorbol 12-myristate 13-acetate (PMA)-inducible expression of three protein kinase C (PKC)-regulated metalloproteinases, MMP-3, MMP-9, and MMP-13, in cultured cells as well as in vivo in sc tumors.	Tetradecanoylphorbol Acetate	141-144	matrix metallopeptidase 3	Mus musculus	229-234
19591805-3	2009	B1 and B2, inhibited tumor necrosis factor alpha (TNFalpha)- and phorbol 12-myristate 13-acetate (PMA)-induced transactivation of NF-kappaB-driven genes and the increase of NF-kappaB-DNA nuclear binding in Jurkat T cells.	Tetradecanoylphorbol Acetate	65-96	membrane spanning 4-domains A1	Homo sapiens	0-9
19887558-5	2009	Cotreatment with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, dramatically inhibited the HDACi-mediated increase in FADD recruitment and sensitization to TRAIL-induced apoptosis and both of these were reversed by PKC inhibitors.	Tetradecanoylphorbol Acetate	17-48	Fas associated via death domain	Homo sapiens	146-150
19887558-5	2009	Cotreatment with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, dramatically inhibited the HDACi-mediated increase in FADD recruitment and sensitization to TRAIL-induced apoptosis and both of these were reversed by PKC inhibitors.	Tetradecanoylphorbol Acetate	50-53	Fas associated via death domain	Homo sapiens	146-150
19887558-6	2009	Thus, enhanced FADD recruitment is a critical step in HDACi-mediated sensitization of CLL cells to TRAIL-induced apoptosis and this step is differentially affected by HDACi and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	177-208	Fas associated via death domain	Homo sapiens	15-19
19541853-4	2009	After topical treatment of mouse skin with dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoting agent, there was a 4-fold increase in the number of papillomas per mouse and 50.8% increase in the incidence of papilloma formation in the CAD knockout mice compared with wild-type littermates.	Tetradecanoylphorbol Acetate	96-132	DNA fragmentation factor, beta subunit	Mus musculus	293-296
19429675-7	2009	However, PKCepsilon translocation is increased when PKCepsilon/14-3-3 interaction is abolished, suggesting that phorbol 12-myristate 13-acetate activation may initiate two sets of PKCepsilon functions, those depending on 14-3-3 and those depending on translocation to cell-cell contacts.	Tetradecanoylphorbol Acetate	112-143	protein kinase C epsilon	Homo sapiens	9-19
19429675-7	2009	However, PKCepsilon translocation is increased when PKCepsilon/14-3-3 interaction is abolished, suggesting that phorbol 12-myristate 13-acetate activation may initiate two sets of PKCepsilon functions, those depending on 14-3-3 and those depending on translocation to cell-cell contacts.	Tetradecanoylphorbol Acetate	112-143	protein kinase C epsilon	Homo sapiens	52-62
19429675-7	2009	However, PKCepsilon translocation is increased when PKCepsilon/14-3-3 interaction is abolished, suggesting that phorbol 12-myristate 13-acetate activation may initiate two sets of PKCepsilon functions, those depending on 14-3-3 and those depending on translocation to cell-cell contacts.	Tetradecanoylphorbol Acetate	112-143	protein kinase C epsilon	Homo sapiens	52-62
19509226-10	2009	The expression and activity of the AMP-activated protein kinase LKB1 was examined and found to be significantly decreased following either forskolin/PMA or leptin treatment.	Tetradecanoylphorbol Acetate	149-152	serine/threonine kinase 11	Homo sapiens	64-68
20230530-3	2010	When cells were treated with phorbol 12-myristate 13-acetate (PMA), RNF13 avoided proteolysis.	Tetradecanoylphorbol Acetate	62-65	ring finger protein 13	Homo sapiens	68-73
20459780-7	2010	PMA/ionomycin stimulation induced a stronger up-regulation of T cell activation than of B cell activation with dominance toward a Th1 response, including IL2, CD69 and TNFRSF9 (tumor necrosis factor receptor superfamily, member 9) genes.	Tetradecanoylphorbol Acetate	0-3	TNF receptor superfamily member 9	Sus scrofa	168-175
20459780-7	2010	PMA/ionomycin stimulation induced a stronger up-regulation of T cell activation than of B cell activation with dominance toward a Th1 response, including IL2, CD69 and TNFRSF9 (tumor necrosis factor receptor superfamily, member 9) genes.	Tetradecanoylphorbol Acetate	0-3	TNF receptor superfamily member 9	Sus scrofa	177-229
20223829-5	2010	We characterized S-glutathionylation of A9; GSSG and GSNO generated S-glutathionylated A8 (A8-SSG) and A9 (A9-SSG) in vitro, whereas only A9-SSG was detected in cytosol of neutrophils activated with phorbol myristate acetate (PMA) but not with fMLP or opsonized zymosan.	Tetradecanoylphorbol Acetate	199-224	brain protein 8	Mus musculus	91-97
20223829-5	2010	We characterized S-glutathionylation of A9; GSSG and GSNO generated S-glutathionylated A8 (A8-SSG) and A9 (A9-SSG) in vitro, whereas only A9-SSG was detected in cytosol of neutrophils activated with phorbol myristate acetate (PMA) but not with fMLP or opsonized zymosan.	Tetradecanoylphorbol Acetate	199-224	UDP glucuronosyltransferase 1 family, polypeptide A6B	Mus musculus	107-113
20223829-5	2010	We characterized S-glutathionylation of A9; GSSG and GSNO generated S-glutathionylated A8 (A8-SSG) and A9 (A9-SSG) in vitro, whereas only A9-SSG was detected in cytosol of neutrophils activated with phorbol myristate acetate (PMA) but not with fMLP or opsonized zymosan.	Tetradecanoylphorbol Acetate	226-229	UDP glucuronosyltransferase 1 family, polypeptide A6B	Mus musculus	40-42
20223829-5	2010	We characterized S-glutathionylation of A9; GSSG and GSNO generated S-glutathionylated A8 (A8-SSG) and A9 (A9-SSG) in vitro, whereas only A9-SSG was detected in cytosol of neutrophils activated with phorbol myristate acetate (PMA) but not with fMLP or opsonized zymosan.	Tetradecanoylphorbol Acetate	226-229	brain protein 8	Mus musculus	87-89
20223829-5	2010	We characterized S-glutathionylation of A9; GSSG and GSNO generated S-glutathionylated A8 (A8-SSG) and A9 (A9-SSG) in vitro, whereas only A9-SSG was detected in cytosol of neutrophils activated with phorbol myristate acetate (PMA) but not with fMLP or opsonized zymosan.	Tetradecanoylphorbol Acetate	226-229	brain protein 8	Mus musculus	91-97
20223829-5	2010	We characterized S-glutathionylation of A9; GSSG and GSNO generated S-glutathionylated A8 (A8-SSG) and A9 (A9-SSG) in vitro, whereas only A9-SSG was detected in cytosol of neutrophils activated with phorbol myristate acetate (PMA) but not with fMLP or opsonized zymosan.	Tetradecanoylphorbol Acetate	226-229	UDP glucuronosyltransferase 1 family, polypeptide A6B	Mus musculus	107-113
20359209-8	2010	The combination of large TPA cross sections and high emission quantum yields makes the title benzothiazole-based dyes attractive for applications involving two-photon excited fluorescence (TPEF).	Tetradecanoylphorbol Acetate	25-28	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	189-193
20388733-6	2010	We also show that phosphorylation of T538 is involved in the activation of LFA-1 integrins by TPA.	Tetradecanoylphorbol Acetate	94-97	integrin alpha L	Mus musculus	75-80
20106976-3	2010	The level of nSMase2 phosphorylation can be modulated by treatment with anisomycin or phorbol 12-myristate 13-acetate (PMA/12-O-tetradecanoylphorbol-13-acetate), suggesting that p38 mitogen-activated protein kinase (MAPK) and protein kinases Cs are upstream of nSMase2 phosphorylation.	Tetradecanoylphorbol Acetate	86-117	sphingomyelin phosphodiesterase 3	Homo sapiens	13-20
20106976-3	2010	The level of nSMase2 phosphorylation can be modulated by treatment with anisomycin or phorbol 12-myristate 13-acetate (PMA/12-O-tetradecanoylphorbol-13-acetate), suggesting that p38 mitogen-activated protein kinase (MAPK) and protein kinases Cs are upstream of nSMase2 phosphorylation.	Tetradecanoylphorbol Acetate	86-117	sphingomyelin phosphodiesterase 3	Homo sapiens	261-268
20106976-3	2010	The level of nSMase2 phosphorylation can be modulated by treatment with anisomycin or phorbol 12-myristate 13-acetate (PMA/12-O-tetradecanoylphorbol-13-acetate), suggesting that p38 mitogen-activated protein kinase (MAPK) and protein kinases Cs are upstream of nSMase2 phosphorylation.	Tetradecanoylphorbol Acetate	119-122	sphingomyelin phosphodiesterase 3	Homo sapiens	13-20
20106976-3	2010	The level of nSMase2 phosphorylation can be modulated by treatment with anisomycin or phorbol 12-myristate 13-acetate (PMA/12-O-tetradecanoylphorbol-13-acetate), suggesting that p38 mitogen-activated protein kinase (MAPK) and protein kinases Cs are upstream of nSMase2 phosphorylation.	Tetradecanoylphorbol Acetate	119-122	sphingomyelin phosphodiesterase 3	Homo sapiens	261-268
20106976-3	2010	The level of nSMase2 phosphorylation can be modulated by treatment with anisomycin or phorbol 12-myristate 13-acetate (PMA/12-O-tetradecanoylphorbol-13-acetate), suggesting that p38 mitogen-activated protein kinase (MAPK) and protein kinases Cs are upstream of nSMase2 phosphorylation.	Tetradecanoylphorbol Acetate	123-159	sphingomyelin phosphodiesterase 3	Homo sapiens	13-20
20074601-4	2010	In vitro stimulation of lymph node cells with either TG, staphylococcus enterotoxin B, or phorbol 12-myristate 13-acetate/ionomycin revealed an interferon-gamma expression in T-bet(+) B cells only in the patient and not in controls.	Tetradecanoylphorbol Acetate	90-121	T-box transcription factor 21	Homo sapiens	175-180
19618379-6	2010	PBMCs were isolated from the donors and used to assess spontaneous and PMA-stimulated secretion of TNF-alpha, IL-6, and IL-1beta.	Tetradecanoylphorbol Acetate	71-74	interleukin 1 alpha	Homo sapiens	120-128
19673702-8	2010	Inhibition of PKCzeta by its myristoylated pseudosubstrate significantly decreased the PMA-stimulated phosphorylation of the p47phox in LPS-pretreated cells, suggesting that PKCzeta is involved in the iNOS-dependent assembly and activation of NOX.	Tetradecanoylphorbol Acetate	87-90	neutrophil cytosolic factor 1	Mus musculus	125-132
19914200-3	2010	Herein, we report that deletion of 21 amino acids from the COOH-terminus of SphK1 (1-363) results in increased catalytic activity relative to wild-type SphK1 (1-384) which is independent of the phosphorylation state of Serine 225 and PMA stimulation.	Tetradecanoylphorbol Acetate	234-237	sphingosine kinase 1	Homo sapiens	76-81
19914200-5	2010	Together the evidence indicates that the COOH-terminal region of SphK1 encompasses a structural element that is necessary for the increase in catalytic activity in response to PMA treatment and that its deletion renders SphK1 constitutively active with respect to PMA treatment.	Tetradecanoylphorbol Acetate	176-179	sphingosine kinase 1	Homo sapiens	65-70
19854260-7	2010	Screening different activators of basic intracellular second messenger systems for their influence on NT-3 synthesis revealed that forskolin (20 microM), dibutyryl cAMP (dBcAMP) (100 microM), as well as calcimycin (1 microM) (Ca(2+) ionophore A23187) and phorbol 12-myristate 13-acetate (TPA) (100 nM), markedly increased the cellular level of NT-3 protein.	Tetradecanoylphorbol Acetate	255-286	neurotrophin 3	Rattus norvegicus	102-106
19854260-7	2010	Screening different activators of basic intracellular second messenger systems for their influence on NT-3 synthesis revealed that forskolin (20 microM), dibutyryl cAMP (dBcAMP) (100 microM), as well as calcimycin (1 microM) (Ca(2+) ionophore A23187) and phorbol 12-myristate 13-acetate (TPA) (100 nM), markedly increased the cellular level of NT-3 protein.	Tetradecanoylphorbol Acetate	288-291	neurotrophin 3	Rattus norvegicus	102-106
19831719-0	2010	The protein kinase C activator phorbol myristate acetate decreases brain edema by aquaporin 4 downregulation after middle cerebral artery occlusion in the rat.	Tetradecanoylphorbol Acetate	31-56	aquaporin 4	Rattus norvegicus	82-93
19831719-1	2010	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) is known to interact with aquaporin 4 (AQP 4), a water-selective transporting protein that is abundant in astrocytes, and has experimentally been found to decrease osmotically-induced cell swelling.	Tetradecanoylphorbol Acetate	31-62	aquaporin 4	Rattus norvegicus	95-106
19831719-1	2010	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) is known to interact with aquaporin 4 (AQP 4), a water-selective transporting protein that is abundant in astrocytes, and has experimentally been found to decrease osmotically-induced cell swelling.	Tetradecanoylphorbol Acetate	31-62	aquaporin 4	Rattus norvegicus	108-113
19831719-1	2010	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) is known to interact with aquaporin 4 (AQP 4), a water-selective transporting protein that is abundant in astrocytes, and has experimentally been found to decrease osmotically-induced cell swelling.	Tetradecanoylphorbol Acetate	64-67	aquaporin 4	Rattus norvegicus	95-106
19831719-1	2010	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) is known to interact with aquaporin 4 (AQP 4), a water-selective transporting protein that is abundant in astrocytes, and has experimentally been found to decrease osmotically-induced cell swelling.	Tetradecanoylphorbol Acetate	64-67	aquaporin 4	Rattus norvegicus	108-113
20026373-2	2010	The topical application of these phenolics 15min prior to TPA resulted in a significant decrease in the NF-kappaB activation which was measured in terms of p65-DNA binding.	Tetradecanoylphorbol Acetate	58-61	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	156-159
20026373-3	2010	Tannic acid was the most potent inhibitor of the TPA-stimulated p65-DNA binding, while chlorogenic acid was the least effective compound.	Tetradecanoylphorbol Acetate	49-52	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	64-67
20936133-4	2010	This correlation was abolished when the cells were stimulated with TPA and ionomycin, which bypass TCR and introduce signals directly into the cells, but the production of IFN-gamma by SLE T cells remained abnormally elevated.	Tetradecanoylphorbol Acetate	67-70	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	99-102
19626033-6	2010	Unexpectedly, topical treatment of K14-RIP4 mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced dramatic, neutrophilic inflammation, an effect that was independent of tumor necrosis factor type 1 receptor (TNFR1/p55) function.	Tetradecanoylphorbol Acetate	54-90	keratin 14	Mus musculus	35-38
19626033-6	2010	Unexpectedly, topical treatment of K14-RIP4 mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced dramatic, neutrophilic inflammation, an effect that was independent of tumor necrosis factor type 1 receptor (TNFR1/p55) function.	Tetradecanoylphorbol Acetate	92-95	keratin 14	Mus musculus	35-38
25214955-2	2010	A new drug, mutated recombinant tissue-type plasminogen activator (rtPAm), is the product of mutation of tPA by changing binding loci with plasminogen activator inhibitor (PAI)-1 to reduce the degradation.	Tetradecanoylphorbol Acetate	68-71	serpin family E member 1	Homo sapiens	139-178
19715751-10	2009	In contrast, TPA-induced MMP-9 and COX-2 expression was decreased by UO126 (MEK 1/2 inhibitor).	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase kinase 1	Homo sapiens	76-83
19704116-5	2009	However, phorbol 12-myristate 13-acetate and ionomycin stimulation or conjugation to susceptible target cells induced myosin-dependent colocalization of Rab27a and Munc13-4 with perforin.	Tetradecanoylphorbol Acetate	9-40	myosin heavy chain 14	Homo sapiens	118-124
19704116-5	2009	However, phorbol 12-myristate 13-acetate and ionomycin stimulation or conjugation to susceptible target cells induced myosin-dependent colocalization of Rab27a and Munc13-4 with perforin.	Tetradecanoylphorbol Acetate	9-40	unc-13 homolog D	Homo sapiens	164-172
19881301-3	2009	In this study, we showed that 7,8,4"-trihydroxyflavone (T-412) significantly decreased IL-4 production both in phorbol 12-myristate 13-acetate (PMA) and ionomycin (PI)-activated EL-4 T cells and concanavalin A (ConA)-activated murine CD4(+) T cells in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	111-142	interleukin 4	Mus musculus	87-91
19416869-4	2009	We have directly tested this hypothesis by determining the effects of dystrophin and utrophin on the microsecond rotational dynamics of a phosphorescent dye attached to C374 on actin, as detected by transient phosphorescence anisotropy (TPA).	Tetradecanoylphorbol Acetate	237-240	dystrophin	Homo sapiens	70-80
19416869-5	2009	Binding of dystrophin or utrophin to actin resulted in significant changes in the TPA decay, increasing the final anisotropy (restricting the rotational amplitude) and decreasing the rotational correlation times (increasing the rotational rates and the torsional flexibility).	Tetradecanoylphorbol Acetate	82-85	dystrophin	Homo sapiens	11-21
3109389-1	1987	The effects of thyrotropin-releasing hormone (TRH) and 12-O-tetradecanoylphorbol 13-acetate (TPA) on cytosolic pH (pHi) were studied on GH4C1 pituitary cells loaded with the fluorescent pH indicator bis(carboxyethyl)carboxyfluorescein (BCECF) and the fluorescent Ca2+ indicator quin2.	Tetradecanoylphorbol Acetate	93-96	glucose-6-phosphate isomerase	Rattus norvegicus	115-118
19432991-8	2009	The counter-regulated genes have been clustered into functional categories and bioinformatic analysis has identified the B-Raf/Mek/Erk branch of the MAP kinase pathway as one containing several genes whose upregulation by TPA is blocked by ATRA.	Tetradecanoylphorbol Acetate	222-225	Braf transforming gene	Mus musculus	121-126
19526458-5	2009	Hepatic leukemia factor (HLF) and D-site albumin promoter-binding protein (DBP) were increased in both bFGF and TPA soft agar colonies and selected for functional validation.	Tetradecanoylphorbol Acetate	112-115	HLF transcription factor, PAR bZIP family member	Homo sapiens	0-23
19526458-5	2009	Hepatic leukemia factor (HLF) and D-site albumin promoter-binding protein (DBP) were increased in both bFGF and TPA soft agar colonies and selected for functional validation.	Tetradecanoylphorbol Acetate	112-115	HLF transcription factor, PAR bZIP family member	Homo sapiens	25-28
3312838-2	1987	In the U937 histiocytic lymphoma line TPA induced an increase in mRNA and cell surface MHC expression which followed induction of c-fos.	Tetradecanoylphorbol Acetate	38-41	FBJ osteosarcoma oncogene	Mus musculus	130-135
19526458-6	2009	Ectopic expression of human HLF and DBP in JB6 cells resulted in a marked increase in TPA- and bFGF-regulated AIG responses.	Tetradecanoylphorbol Acetate	86-89	HLF transcription factor, PAR bZIP family member	Homo sapiens	28-31
19526458-8	2009	Subsequent biological network analysis suggests that many of the differentially expressed genes that are common to bFGF- and TPA-dependent AIG are regulated by c-Myc, SP-1, and HNF-4 transcription factors.	Tetradecanoylphorbol Acetate	125-128	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	160-165
19019167-10	2009	Epidermal growth factor (50 ng/mL) and phorbol 12-myristate 13-acetate (10(-7) mol/L) stimulated the secretion of soluble EMMPRIN and increased the MMP-2 activity, although these agents did not increase the level of EMMPRIN mRNA.	Tetradecanoylphorbol Acetate	39-70	basigin (Ok blood group)	Homo sapiens	122-129
3312838-4	1987	In the pluripotent HL60 promyelocytic line induction of macrophage differentiation with TPA led to c-fos induction and rising MHC levels, whereas induction of granulocyte differentiation with DMSO did not induce c-fos expression and was followed by declining MHC levels.	Tetradecanoylphorbol Acetate	88-91	FBJ osteosarcoma oncogene	Mus musculus	99-104
19019167-10	2009	Epidermal growth factor (50 ng/mL) and phorbol 12-myristate 13-acetate (10(-7) mol/L) stimulated the secretion of soluble EMMPRIN and increased the MMP-2 activity, although these agents did not increase the level of EMMPRIN mRNA.	Tetradecanoylphorbol Acetate	39-70	basigin (Ok blood group)	Homo sapiens	216-223
19605734-1	2009	Here we show that stimulation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) treatment induces a time-dependent decrease in glutamate transport activity due to relocalization of the excitatory amino acid carrier 1 (EAAC1) glutamate transporter from the apical surface of polarized epithelial Madin-Darby canine kidney (MDCK) cells to intracellular compartments.	Tetradecanoylphorbol Acetate	59-90	solute carrier family 1 member 1	Canis lupus familiaris	202-233
19605734-1	2009	Here we show that stimulation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) treatment induces a time-dependent decrease in glutamate transport activity due to relocalization of the excitatory amino acid carrier 1 (EAAC1) glutamate transporter from the apical surface of polarized epithelial Madin-Darby canine kidney (MDCK) cells to intracellular compartments.	Tetradecanoylphorbol Acetate	59-90	solute carrier family 1 member 1	Canis lupus familiaris	235-240
19605734-1	2009	Here we show that stimulation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) treatment induces a time-dependent decrease in glutamate transport activity due to relocalization of the excitatory amino acid carrier 1 (EAAC1) glutamate transporter from the apical surface of polarized epithelial Madin-Darby canine kidney (MDCK) cells to intracellular compartments.	Tetradecanoylphorbol Acetate	92-95	solute carrier family 1 member 1	Canis lupus familiaris	202-233
19605734-1	2009	Here we show that stimulation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) treatment induces a time-dependent decrease in glutamate transport activity due to relocalization of the excitatory amino acid carrier 1 (EAAC1) glutamate transporter from the apical surface of polarized epithelial Madin-Darby canine kidney (MDCK) cells to intracellular compartments.	Tetradecanoylphorbol Acetate	92-95	solute carrier family 1 member 1	Canis lupus familiaris	235-240
19164291-2	2009	The BZLF1 promoter (Zp) normally exhibits only low basal activity but is activated in response to chemical inducers such as 12-O-tetradecanoylphorbol-13-acetate and calcium ionophore.	Tetradecanoylphorbol Acetate	124-160	protein Zta	Human gammaherpesvirus 4	4-9
19164291-8	2009	Silencing of endogenous TORC2 gene expression by RNA interference decreased the levels of the BZLF1 protein in response to 12-O-tetradecanoylphorbol-13-acetate/ionophore.	Tetradecanoylphorbol Acetate	123-159	protein Zta	Human gammaherpesvirus 4	94-99
18941116-2	2009	Here we show that U937-derived, chronically infected U1 cells stimulated with phorbol 12-myristate 13-acetate (PMA) express integrins, uPA, and soluble uPAR at levels similar to those of MDMs.	Tetradecanoylphorbol Acetate	78-109	plasminogen activator, urokinase receptor	Homo sapiens	152-156
18787026-4	2009	We demonstrate that activation of the PKA and PKC pathways, by a cAMP analog dibutyryl (Bu)2cAMP [(Bu)2cAMP] and phorbol 12-myristate 13-acetate (PMA), respectively, markedly decreased DAX-1 expression, an event that was inversely correlated with StAR protein, StAR mRNA, and progesterone levels.	Tetradecanoylphorbol Acetate	113-144	nuclear receptor subfamily 0, group B, member 1	Mus musculus	185-190
18787026-4	2009	We demonstrate that activation of the PKA and PKC pathways, by a cAMP analog dibutyryl (Bu)2cAMP [(Bu)2cAMP] and phorbol 12-myristate 13-acetate (PMA), respectively, markedly decreased DAX-1 expression, an event that was inversely correlated with StAR protein, StAR mRNA, and progesterone levels.	Tetradecanoylphorbol Acetate	113-144	steroidogenic acute regulatory protein	Mus musculus	247-251
18787026-4	2009	We demonstrate that activation of the PKA and PKC pathways, by a cAMP analog dibutyryl (Bu)2cAMP [(Bu)2cAMP] and phorbol 12-myristate 13-acetate (PMA), respectively, markedly decreased DAX-1 expression, an event that was inversely correlated with StAR protein, StAR mRNA, and progesterone levels.	Tetradecanoylphorbol Acetate	113-144	steroidogenic acute regulatory protein	Mus musculus	261-265
18787026-4	2009	We demonstrate that activation of the PKA and PKC pathways, by a cAMP analog dibutyryl (Bu)2cAMP [(Bu)2cAMP] and phorbol 12-myristate 13-acetate (PMA), respectively, markedly decreased DAX-1 expression, an event that was inversely correlated with StAR protein, StAR mRNA, and progesterone levels.	Tetradecanoylphorbol Acetate	146-149	nuclear receptor subfamily 0, group B, member 1	Mus musculus	185-190
18787026-4	2009	We demonstrate that activation of the PKA and PKC pathways, by a cAMP analog dibutyryl (Bu)2cAMP [(Bu)2cAMP] and phorbol 12-myristate 13-acetate (PMA), respectively, markedly decreased DAX-1 expression, an event that was inversely correlated with StAR protein, StAR mRNA, and progesterone levels.	Tetradecanoylphorbol Acetate	146-149	steroidogenic acute regulatory protein	Mus musculus	247-251
18787026-4	2009	We demonstrate that activation of the PKA and PKC pathways, by a cAMP analog dibutyryl (Bu)2cAMP [(Bu)2cAMP] and phorbol 12-myristate 13-acetate (PMA), respectively, markedly decreased DAX-1 expression, an event that was inversely correlated with StAR protein, StAR mRNA, and progesterone levels.	Tetradecanoylphorbol Acetate	146-149	steroidogenic acute regulatory protein	Mus musculus	261-265
18823984-10	2008	PMA and Zymosan produced an increase in annexin V binding, while fMLP and calcium ionophore did not.	Tetradecanoylphorbol Acetate	0-3	annexin A5	Homo sapiens	40-49
19077250-9	2008	Downregulation of PKCepsilon, but not of PKCalpha or PKCdelta, with siRNA led to a suppression of both basal and TPA-stimulated migration.	Tetradecanoylphorbol Acetate	113-116	protein kinase C epsilon	Homo sapiens	18-28
19139002-7	2008	Delphinidin strongly suppressed Raf1 and MEK1 kinase activities and subsequently attenuated TPA-induced phosphorylation of MEK, extracellular signal-regulated kinase (ERK), p90RSK, and MSK.	Tetradecanoylphorbol Acetate	92-95	salt inducible kinase 1	Mus musculus	185-188
18757500-8	2008	In contrast, phorbol 12-myristate-13-acetate (TPA) -induced cleavage of HB-EGF, NRG, and TGF-alpha was dependent on PKC and sensitive to BB94 inhibition.	Tetradecanoylphorbol Acetate	13-44	heparin-binding EGF-like growth factor	Mus musculus	72-78
18757500-8	2008	In contrast, phorbol 12-myristate-13-acetate (TPA) -induced cleavage of HB-EGF, NRG, and TGF-alpha was dependent on PKC and sensitive to BB94 inhibition.	Tetradecanoylphorbol Acetate	13-44	transforming growth factor alpha	Mus musculus	89-98
18757500-8	2008	In contrast, phorbol 12-myristate-13-acetate (TPA) -induced cleavage of HB-EGF, NRG, and TGF-alpha was dependent on PKC and sensitive to BB94 inhibition.	Tetradecanoylphorbol Acetate	46-49	transforming growth factor alpha	Mus musculus	89-98
18534676-2	2008	In addition, the influence of phorbol ester (PMA) on PML NBs formation was analyzed.	Tetradecanoylphorbol Acetate	45-48	PML nuclear body scaffold	Homo sapiens	53-56
18534676-3	2008	A reduced number of PML bodies, which led to relocation of PML NBs closer to the nuclear interior, mostly accompanied RA- and PMA-induced differentiation.	Tetradecanoylphorbol Acetate	126-129	PML nuclear body scaffold	Homo sapiens	20-23
18534676-3	2008	A reduced number of PML bodies, which led to relocation of PML NBs closer to the nuclear interior, mostly accompanied RA- and PMA-induced differentiation.	Tetradecanoylphorbol Acetate	126-129	PML nuclear body scaffold	Homo sapiens	59-62
18719353-0	2008	Induction of the nuclear proto-oncogene c-fos by the phorbol ester TPA and v-H-Ras.	Tetradecanoylphorbol Acetate	67-70	FBJ osteosarcoma oncogene	Mus musculus	25-45
18719353-3	2008	We found a marked synergistic interaction between TPA and a transfected v-Ha-ras oncogene in the activation of c-fos promoter and SRE.	Tetradecanoylphorbol Acetate	50-53	FBJ osteosarcoma oncogene	Mus musculus	111-116
18628783-6	2008	In addition, PROG significantly increased the ratio of tPA bound to neuroserpin, a serine protease inhibitor that can reduce the activity of tPA.	Tetradecanoylphorbol Acetate	141-144	serpin family I member 1	Homo sapiens	68-79
18841451-2	2008	Foxp3 binds to forkhead motifs of about 1,100 genes and the strength of binding increases upon phorbol 12-myristate 13-acetate/ionomycin stimulation.	Tetradecanoylphorbol Acetate	95-126	forkhead box P3	Mus musculus	0-5
18989526-0	2008	Phorbol 12-myristate 13-acetate (PMA) responsive sequence in Galphaq promoter during megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	0-31	G protein subunit alpha q	Homo sapiens	61-68
18989526-0	2008	Phorbol 12-myristate 13-acetate (PMA) responsive sequence in Galphaq promoter during megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	33-36	G protein subunit alpha q	Homo sapiens	61-68
18989526-3	2008	We have reported that Galphaq is upregulated during phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic transformation of human erythroleukemia (HEL) cells and regulated by EGR-1, an early growth transcription factor.	Tetradecanoylphorbol Acetate	52-83	G protein subunit alpha q	Homo sapiens	22-29
18989526-3	2008	We have reported that Galphaq is upregulated during phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic transformation of human erythroleukemia (HEL) cells and regulated by EGR-1, an early growth transcription factor.	Tetradecanoylphorbol Acetate	85-88	G protein subunit alpha q	Homo sapiens	22-29
18989526-3	2008	We have reported that Galphaq is upregulated during phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic transformation of human erythroleukemia (HEL) cells and regulated by EGR-1, an early growth transcription factor.	Tetradecanoylphorbol Acetate	85-88	early growth response 1	Homo sapiens	182-187
18989526-6	2008	In luciferase reporter gene studies in HEL cells, Galphaq 5" upstream promoter sequence -1042/-1 showed an about four-fold increased activity in PMA-treated compared to untreated cells.	Tetradecanoylphorbol Acetate	145-148	G protein subunit alpha q	Homo sapiens	50-57
18989526-8	2008	Gel-shift studies on Galphaq probe (-1042/-1012 bp) revealed binding of EGR-1 with PMA-treated but not untreated nuclear extracts, and this was dependent on the sequence -1042/-1037.	Tetradecanoylphorbol Acetate	83-86	G protein subunit alpha q	Homo sapiens	21-28
18989526-8	2008	Gel-shift studies on Galphaq probe (-1042/-1012 bp) revealed binding of EGR-1 with PMA-treated but not untreated nuclear extracts, and this was dependent on the sequence -1042/-1037.	Tetradecanoylphorbol Acetate	83-86	early growth response 1	Homo sapiens	72-77
18647594-0	2008	Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells.	Tetradecanoylphorbol Acetate	71-74	basigin (Ok blood group)	Homo sapiens	21-28
18541361-5	2008	Moreover, PMA evoked a significant increase in the levels of the cell cycle regulators p21Waf1/Cip1 and p27Kip1.	Tetradecanoylphorbol Acetate	10-13	cyclin dependent kinase inhibitor 1B	Homo sapiens	104-111
18180277-4	2008	TNFRSF1A shedding was examined by stimulation of peripheral blood mononuclear cells (PBMCs) with phorbol 12-myristate 13-acetate followed by flow cytometric analysis (FACS).	Tetradecanoylphorbol Acetate	97-128	TNF receptor superfamily member 1A	Homo sapiens	0-8
18663158-5	2008	Here we report that caveolin-dependent internalization is involved in PKC-epsilon-mediated inhibition of vascular K(ATP) channels (Kir6.1 and SUR2B) by phorbol 12-myristate 13-acetate or angiotensin II in human embryonic kidney 293 cells and human dermal vascular smooth muscle cells.	Tetradecanoylphorbol Acetate	152-183	protein kinase C epsilon	Homo sapiens	70-81
18663158-5	2008	Here we report that caveolin-dependent internalization is involved in PKC-epsilon-mediated inhibition of vascular K(ATP) channels (Kir6.1 and SUR2B) by phorbol 12-myristate 13-acetate or angiotensin II in human embryonic kidney 293 cells and human dermal vascular smooth muscle cells.	Tetradecanoylphorbol Acetate	152-183	potassium inwardly rectifying channel subfamily J member 8	Homo sapiens	131-137
18487372-11	2008	TAPI-2 inhibited the PMA-induced release of sTNFR1 receptor and enhanced the surface expression of TNFR1 in HCECs in a dose-dependent manner.	Tetradecanoylphorbol Acetate	21-24	TNF receptor superfamily member 1A	Homo sapiens	45-50
18551429-2	2008	In the present study, patch-clamp whole-cell recording and transwell-migration assays were used to examine the effects of TGF-beta1- and phorbol 12-myristate 13-acetate (PMA)-induced expression of I(A) channels on myofibroblast migration and its modulation by the protein kinase A (PKA) pathway.	Tetradecanoylphorbol Acetate	170-173	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	264-280
18551429-2	2008	In the present study, patch-clamp whole-cell recording and transwell-migration assays were used to examine the effects of TGF-beta1- and phorbol 12-myristate 13-acetate (PMA)-induced expression of I(A) channels on myofibroblast migration and its modulation by the protein kinase A (PKA) pathway.	Tetradecanoylphorbol Acetate	170-173	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	282-285
18481152-3	2008	We hypothesized that a single-section approach (by either frozen section [FS] or touch preparation analysis [TPA]) could be accurate for intraoperative SLN evaluation.	Tetradecanoylphorbol Acetate	109-112	sarcolipin	Homo sapiens	152-155
18400024-8	2008	Higher levels of p53 and p21 in skin cells pre-treated with PBP fractions followed by TPA treatment as compared to only TPA-treated animals suggested possible activation of a cell cycle checkpoint.	Tetradecanoylphorbol Acetate	86-89	transformation related protein 53, pseudogene	Mus musculus	17-20
18445064-6	2008	Human placental villous macrophages and phorbol myristate acetate (PMA)-treated THP-1 cells expressed the gene encoding an exon 9-deleted form of the luteinizing hormone/chorionic gonadotropin (LH/CG) receptor; expression of the full-length receptor was not determined.	Tetradecanoylphorbol Acetate	40-65	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	150-209
18445064-6	2008	Human placental villous macrophages and phorbol myristate acetate (PMA)-treated THP-1 cells expressed the gene encoding an exon 9-deleted form of the luteinizing hormone/chorionic gonadotropin (LH/CG) receptor; expression of the full-length receptor was not determined.	Tetradecanoylphorbol Acetate	67-70	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	150-209
18551458-5	2008	In the case of AP-1, the binding of c-Jun subunit was particularly affected, while only slight effect on c-Fos binding to TPA-responsive element (AP-1 binding consensus sequence) (TRE) site was observed.	Tetradecanoylphorbol Acetate	122-125	FBJ osteosarcoma oncogene	Mus musculus	105-110
18407667-9	2008	Interestingly, vimentin, the IF characteristic of leukocytes, is one of the major proteins recognized by SP-A in protein extracts of U937 cells after PMA-induced differentiation of this monocytic cell line.	Tetradecanoylphorbol Acetate	150-153	vimentin	Homo sapiens	15-23
18183498-3	2008	Blockade of gene expression of Snail by antisense oligodeoxynucleotide and/or siRNA technique can prevent not only the TPA-triggered EMT/cell migration and growth inhibition of HepG2 but also TPA-induced down-regulation of E-cadherin and up-regulation of p15(INK4b).	Tetradecanoylphorbol Acetate	119-122	IL2 inducible T cell kinase	Homo sapiens	133-136
18353096-3	2008	The expression of ZFP185 protein was up-regulated significantly in T lymphocytes during their activation by phorbol 12-myristate 13-acetate (PMA)/ionomycin, compared with non-activated T lymphocytes, as determined by western blot assays.	Tetradecanoylphorbol Acetate	108-139	zinc finger protein 185	Mus musculus	18-24
18353096-3	2008	The expression of ZFP185 protein was up-regulated significantly in T lymphocytes during their activation by phorbol 12-myristate 13-acetate (PMA)/ionomycin, compared with non-activated T lymphocytes, as determined by western blot assays.	Tetradecanoylphorbol Acetate	141-144	zinc finger protein 185	Mus musculus	18-24
18089565-7	2008	Evidence for the beta-arrestin independence of PMA-induced internalization of LPA 1 comes from the observations that beta-arrestin2-GFP is not recruited to the plasma membrane upon PMA treatment and that LPA 1 is readily internalized in beta-arrestin1/2 knock-out mouse embryonic fibroblasts.	Tetradecanoylphorbol Acetate	47-50	lysophosphatidic acid receptor 1	Mus musculus	78-83
18089565-7	2008	Evidence for the beta-arrestin independence of PMA-induced internalization of LPA 1 comes from the observations that beta-arrestin2-GFP is not recruited to the plasma membrane upon PMA treatment and that LPA 1 is readily internalized in beta-arrestin1/2 knock-out mouse embryonic fibroblasts.	Tetradecanoylphorbol Acetate	47-50	arrestin, beta 2	Mus musculus	117-131
17647275-6	2008	PMA treatment also resulted in increase of insulin receptor substrate 1 (IRS1) serine312 (Ser312) and serine1101 (Ser1101) phosphorylation and induction of IRS1 degradation.	Tetradecanoylphorbol Acetate	0-3	insulin receptor substrate 1	Homo sapiens	43-71
17647275-6	2008	PMA treatment also resulted in increase of insulin receptor substrate 1 (IRS1) serine312 (Ser312) and serine1101 (Ser1101) phosphorylation and induction of IRS1 degradation.	Tetradecanoylphorbol Acetate	0-3	insulin receptor substrate 1	Homo sapiens	73-77
17647275-6	2008	PMA treatment also resulted in increase of insulin receptor substrate 1 (IRS1) serine312 (Ser312) and serine1101 (Ser1101) phosphorylation and induction of IRS1 degradation.	Tetradecanoylphorbol Acetate	0-3	insulin receptor substrate 1	Homo sapiens	156-160
17647275-10	2008	From the results, it was concluded that PMA-induced insulin resistance, through induction of serine phosphorylation of IRS1 mediated by activated JNK and PKCs, increases ApoB secretion in Chang liver cells.	Tetradecanoylphorbol Acetate	40-43	insulin receptor substrate 1	Homo sapiens	119-123
18198130-0	2008	Induction of proline-rich tyrosine kinase2 (Pyk2) through C/EBPbeta is involved in PMA-induced monocyte differentiation.	Tetradecanoylphorbol Acetate	83-86	protein tyrosine kinase 2 beta	Homo sapiens	13-42
18198130-0	2008	Induction of proline-rich tyrosine kinase2 (Pyk2) through C/EBPbeta is involved in PMA-induced monocyte differentiation.	Tetradecanoylphorbol Acetate	83-86	protein tyrosine kinase 2 beta	Homo sapiens	44-48
18053799-6	2008	In the myeloid cells, but not in the epithelial cells, we observed that the leukotriene C(4) synthase promoter activity was stimulated by 12-O-tetradecanoylphorbol-13-acetate and all-trans-retinoic acid.	Tetradecanoylphorbol Acetate	138-174	leukotriene C4 synthase	Homo sapiens	76-101
18207029-4	2008	Culture in the presence of TNF-alpha induced some differentiation, but only treatment with PMA and ionomycin (with or without prior culture in GM-CSF and IL-4) induced morphological and phenotypic changes consistent with DC-like maturation, and even these maximally differentiated KG-1 cells showed lower levels of surface marker expression, macromolecular endocytosis, and ability to stimulate in allogeneic MLR compared with in vitro monocyte-derived DCs.	Tetradecanoylphorbol Acetate	91-94	colony stimulating factor 2	Homo sapiens	143-149
18234971-8	2008	Furthermore, inhibition of c-Jun/activator protein 1 pathway or JNKs/c-Jun pathway by overexpression of dominant negative mutants of c-Jun, or MKK4 and MKK7 together, resulted in impairment of COX-2 induction, suggesting that JNK1/c-Jun/activator protein 1 pathway is involved in TPA-associated COX-2 induction.	Tetradecanoylphorbol Acetate	280-283	mitogen-activated protein kinase kinase 4	Mus musculus	143-147
18067864-0	2007	Phorbol myristate acetate-induced Egr-1 expression is suppressed by phospholipase D isozymes in human glioma cells.	Tetradecanoylphorbol Acetate	0-25	early growth response 1	Homo sapiens	34-39
18067864-2	2007	Here, we found that overexpression of phospholipase D (PLD) isozymes decreased tumor promoter phorbol myristate acetate (PMA)-induced Egr-1 expression and transactivation in glioma cells.	Tetradecanoylphorbol Acetate	94-119	early growth response 1	Homo sapiens	134-139
17880928-4	2007	Rh2 inhibited the PMA-induced mRNA expression of MMP-1, -3, -9, and -14, suggesting that Rh2 has a broad-spectrum inhibitory effect on MMPs.	Tetradecanoylphorbol Acetate	18-21	Rh associated glycoprotein	Homo sapiens	0-3
17880928-4	2007	Rh2 inhibited the PMA-induced mRNA expression of MMP-1, -3, -9, and -14, suggesting that Rh2 has a broad-spectrum inhibitory effect on MMPs.	Tetradecanoylphorbol Acetate	18-21	matrix metallopeptidase 1	Homo sapiens	49-71
17880928-4	2007	Rh2 inhibited the PMA-induced mRNA expression of MMP-1, -3, -9, and -14, suggesting that Rh2 has a broad-spectrum inhibitory effect on MMPs.	Tetradecanoylphorbol Acetate	18-21	Rh associated glycoprotein	Homo sapiens	89-92
17880928-8	2007	Furthermore, Rh2 significantly repressed the PMA-mediated activation of p38 MAPK, ERK and JNK, which are upstream modulators of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	45-48	Rh associated glycoprotein	Homo sapiens	13-16
17962218-4	2007	Pre-treatment with 5-OH-HxMF resulted in the reduction of TPA-induced nuclear translocation of nuclear factor-kappaB (NF-kappaB) subunit and DNA binding by blocking phosphorylation of inhibitor kappaB (IkappaB) alpha and p65 and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	58-61	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	221-224
17786281-3	2007	These effects were blocked by a tyrosine kinase inhibitor (PP2) or Src small interfering RNA (siRNA), indicating that Src was involved in the PMA-induced activation of Cas/Crk/Rac1 signaling pathway.	Tetradecanoylphorbol Acetate	142-145	BCAR1 scaffold protein, Cas family member	Homo sapiens	168-171
17786281-10	2007	We propose that PMA-induced migration was dependent on activation of PKC/Src/Cas/Crk/Rac1 signaling pathway via modulating cytoskeletal reorganization during glioblastoma cell migration.	Tetradecanoylphorbol Acetate	16-19	BCAR1 scaffold protein, Cas family member	Homo sapiens	77-80
19916923-6	2009	Angiostatin K1-3 (up to 2 microM) had no effect, while 2 microM angiostatins K1-4 and K1-4.5 inhibited the fibrin-stimulated Glu-plasminogen activation by tPA by 50 and 100%, respectively.	Tetradecanoylphorbol Acetate	155-158	keratin 14	Homo sapiens	77-81
19916923-6	2009	Angiostatin K1-3 (up to 2 microM) had no effect, while 2 microM angiostatins K1-4 and K1-4.5 inhibited the fibrin-stimulated Glu-plasminogen activation by tPA by 50 and 100%, respectively.	Tetradecanoylphorbol Acetate	155-158	keratin 14	Homo sapiens	86-90
19492415-4	2009	Using immunocytochemistry approach we studied the subcellular distribution of endogenous Jmjd6 protein in THP-1 cells activated with phorbol 12-myristate 13 acetate (PMA).	Tetradecanoylphorbol Acetate	133-164	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	89-94
19492415-4	2009	Using immunocytochemistry approach we studied the subcellular distribution of endogenous Jmjd6 protein in THP-1 cells activated with phorbol 12-myristate 13 acetate (PMA).	Tetradecanoylphorbol Acetate	166-169	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	89-94
20177957-0	2009	Specific subcellular targeting of PKCalpha and PKCepsilon in normal and tumoral lactotroph cells by PMA-mitogenic stimulus.	Tetradecanoylphorbol Acetate	100-103	protein kinase C epsilon	Homo sapiens	47-57
19738056-7	2009	However, Aurora-A overexpression combined with exposure to TPA and the mutagen 7,12-dimethylbenz(a)anthracene accelerated SCC development with greater metastatic activity than control mice, indicating that Aurora-A cannot initiate skin carcinogenesis but rather promotes the malignant conversion of skin papillomas.	Tetradecanoylphorbol Acetate	59-62	serpin family B member 3	Homo sapiens	122-125
19282384-3	2009	In the present study, we demonstrate that activation of the PKC pathway, by phorbol 12-myristate 13-acetate (PMA), was capable of potentiating dibutyryl cAMP [(Bu)(2)cAMP]-stimulated StAR expression, StAR phosphorylation, and progesterone synthesis in both mouse Leydig (MA-10) and granulosa (KK-1) tumor cells.	Tetradecanoylphorbol Acetate	76-107	steroidogenic acute regulatory protein	Mus musculus	183-187
19282384-3	2009	In the present study, we demonstrate that activation of the PKC pathway, by phorbol 12-myristate 13-acetate (PMA), was capable of potentiating dibutyryl cAMP [(Bu)(2)cAMP]-stimulated StAR expression, StAR phosphorylation, and progesterone synthesis in both mouse Leydig (MA-10) and granulosa (KK-1) tumor cells.	Tetradecanoylphorbol Acetate	76-107	steroidogenic acute regulatory protein	Mus musculus	200-204
19282384-3	2009	In the present study, we demonstrate that activation of the PKC pathway, by phorbol 12-myristate 13-acetate (PMA), was capable of potentiating dibutyryl cAMP [(Bu)(2)cAMP]-stimulated StAR expression, StAR phosphorylation, and progesterone synthesis in both mouse Leydig (MA-10) and granulosa (KK-1) tumor cells.	Tetradecanoylphorbol Acetate	109-112	steroidogenic acute regulatory protein	Mus musculus	183-187
19282384-3	2009	In the present study, we demonstrate that activation of the PKC pathway, by phorbol 12-myristate 13-acetate (PMA), was capable of potentiating dibutyryl cAMP [(Bu)(2)cAMP]-stimulated StAR expression, StAR phosphorylation, and progesterone synthesis in both mouse Leydig (MA-10) and granulosa (KK-1) tumor cells.	Tetradecanoylphorbol Acetate	109-112	steroidogenic acute regulatory protein	Mus musculus	200-204
19609061-4	2009	The application of TPA increased the PiCl-induced infiltration of eosinophils and mast cells at the inflammatory site and shifted the cytokine milieu from Th1 to Th2.	Tetradecanoylphorbol Acetate	19-22	heart and neural crest derivatives expressed 2	Mus musculus	162-165
19609061-5	2009	The expression of the Th2-inducing cytokine thymic stromal lymphopoietin (TSLP) mRNA was also increased by TPA.	Tetradecanoylphorbol Acetate	107-110	heart and neural crest derivatives expressed 2	Mus musculus	22-25
19609061-6	2009	These findings suggested that the induction of antigen-nonspecific inflammation by TPA before the antigen challenge enhanced the Th2 response and modified the PiCl-induced delayed type-hypersensitivity.	Tetradecanoylphorbol Acetate	83-86	heart and neural crest derivatives expressed 2	Mus musculus	129-132
19011160-3	2009	PKCepsilon activation with phorbol-12-myristate-13-acetate significantly decreased Ca(2+) spark frequency and increased Ca(2+) spark amplitude.	Tetradecanoylphorbol Acetate	27-58	protein kinase C epsilon	Homo sapiens	0-10
19482637-3	2009	It has been recently described that biomarkers such as MMP-9 or fibronectin, might be used to select patients at higher risk of HT, and high PAI-1 that interferes with tPA-induced recanalization, might predict clot-lysis resistance and poor outcome.	Tetradecanoylphorbol Acetate	168-171	serpin family E member 1	Homo sapiens	141-146
19279008-5	2009	Knockdown of GBA1 also evoked the hyperproduction of IL-6 in response to 4beta phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	73-110	glucosylceramidase beta	Homo sapiens	13-17
19279011-8	2009	Silencing GBA1 by small interfering RNAs significantly attenuated acid glucocerebrosidase activity and decreased PMA-induced formation of ceramide by 50%.	Tetradecanoylphorbol Acetate	113-116	glucosylceramidase beta	Homo sapiens	10-14
19279011-9	2009	Silencing GBA1 blocked PMA-induced degradation of glucosylceramide and generation of sphingosine, the source for ceramide biosynthesis.	Tetradecanoylphorbol Acetate	23-26	glucosylceramidase beta	Homo sapiens	10-14
19048368-5	2009	Activation of intracellular cyclic adenosine monophosphate or protein kinase C with forskolin and phorbol 12-myristate 13-acetate, respectively, was able to completely abolish the MCP-1-induced migration.	Tetradecanoylphorbol Acetate	98-129	C-C motif chemokine ligand 2	Homo sapiens	180-185
19168130-6	2009	Following induction of PKCepsilonA/E-expression by doxycycline for 24 h and additional short-term treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), PKCepsilonA/E translocated to the plasma membrane and increased phosphorylation of MARCKS(S152/156).	Tetradecanoylphorbol Acetate	113-149	protein kinase C epsilon	Homo sapiens	23-36
19168130-6	2009	Following induction of PKCepsilonA/E-expression by doxycycline for 24 h and additional short-term treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), PKCepsilonA/E translocated to the plasma membrane and increased phosphorylation of MARCKS(S152/156).	Tetradecanoylphorbol Acetate	113-149	protein kinase C epsilon	Homo sapiens	157-170
19168130-7	2009	Treatment with doxycycline/TPA or TPA alone increased phosphorylations of Elk-1(S383), PDK1(S241), Rb(S807/S811), PKCdelta(T505), p38MAPK(T180/Y182), MEK1/2(S217/S221) and ERK2(T185/T187).	Tetradecanoylphorbol Acetate	27-30	mitogen-activated protein kinase kinase 1	Homo sapiens	150-156
19168130-7	2009	Treatment with doxycycline/TPA or TPA alone increased phosphorylations of Elk-1(S383), PDK1(S241), Rb(S807/S811), PKCdelta(T505), p38MAPK(T180/Y182), MEK1/2(S217/S221) and ERK2(T185/T187).	Tetradecanoylphorbol Acetate	34-37	mitogen-activated protein kinase kinase 1	Homo sapiens	150-156
19065636-5	2009	However, phosphorylation of 4E-BP1 and S6K1 on Thr421/Ser424 was significantly decreased in differentiated Dami cells induced by phorbol 12-myristate 13-acetate (PMA), concomitant with increased expression of cyclin D1 and p21 and cyclin D3.	Tetradecanoylphorbol Acetate	162-165	ribosomal protein S6 kinase B1	Homo sapiens	39-43
3027706-2	1987	The parental cell line 84.5, a deletion mutant of the 721 LCL cell line, can be induced to produce IL-1 activity when stimulated by certain inducers such as phorbol 12-myristate 13-acetate in the presence of fetal calf serum.	Tetradecanoylphorbol Acetate	157-188	interleukin 1 alpha	Homo sapiens	99-103
17886198-4	2007	In addition, quercetin, kaempferol, apigenin and wogonin (12.5-25.0 microM) strongly inhibited MMP-1 induction in 12-O-tetradecanoylphorbol 13-acetate-treated human dermal fibroblasts, but naringenin (a flavanone) did not.	Tetradecanoylphorbol Acetate	114-150	matrix metallopeptidase 1	Homo sapiens	95-100
17546494-8	2007	DNA binding activity of USF1/2 is marginally stimulated by PMA/ ionomycin treatment, and all three factors appear to remain associated with the LTR throughout the course of induction.	Tetradecanoylphorbol Acetate	59-62	upstream transcription factor 1	Homo sapiens	24-30
3108164-0	1987	Interleukin-2 responses of MRL/lpr mouse splenocytes and lymph node cells induced by TPA and A23187.	Tetradecanoylphorbol Acetate	85-88	interleukin 2	Mus musculus	0-13
17640620-1	2007	We investigated the mechanism of phorbol 12-myristate 13-acetate (PMA)-induced migration of glioblastoma cells focusing on the p38 mitogen-activated protein kinase (MAPK)/heat shock protein 27 (Hsp27) pathway.	Tetradecanoylphorbol Acetate	33-64	heat shock protein family B (small) member 1	Homo sapiens	194-199
3108164-1	1987	Treatment of splenocytes and lymph node cells of 5 month-old MRL/lpr mice with TPA induced IL-2-dependent proliferation of the cells in the presence of CA++.	Tetradecanoylphorbol Acetate	79-82	interleukin 2	Mus musculus	91-95
17640620-10	2007	In conclusion, p38MAPK activation followed by Hsp27 phosphorylation was required for PMA-induced migration.	Tetradecanoylphorbol Acetate	85-88	heat shock protein family B (small) member 1	Homo sapiens	46-51
3108164-3	1987	The combination of TPA and A23187 in the lpr cells induced both proliferation and production of IL-2 in a Ca++-dependent fashion.	Tetradecanoylphorbol Acetate	19-22	interleukin 2	Mus musculus	96-100
3609441-1	1987	12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC, EC 4.1.1.17) in normal, preneoplastic and malignant rat brain cells in culture, but treatment with phorbol, acetate or medium shift resulted in a similar response.	Tetradecanoylphorbol Acetate	0-37	ornithine decarboxylase 1	Rattus norvegicus	52-75
17389615-10	2007	These studies are the first to show that loss of one allele of cdc2l gene, encoding CDK11, facilitates DMBA/TPA-induced skin carcinogenesis in vivo.	Tetradecanoylphorbol Acetate	108-111	cyclin-dependent kinase 19	Mus musculus	84-89
19167408-10	2009	On the contrary, cells treated with phorbol-12-myristate-13-acetate (PMA) had an increase in type II VLDLR expression, whereas the beta-catenin was increased.	Tetradecanoylphorbol Acetate	36-67	very low density lipoprotein receptor	Homo sapiens	101-106
3609441-1	1987	12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC, EC 4.1.1.17) in normal, preneoplastic and malignant rat brain cells in culture, but treatment with phorbol, acetate or medium shift resulted in a similar response.	Tetradecanoylphorbol Acetate	0-37	ornithine decarboxylase 1	Rattus norvegicus	77-80
19167408-10	2009	On the contrary, cells treated with phorbol-12-myristate-13-acetate (PMA) had an increase in type II VLDLR expression, whereas the beta-catenin was increased.	Tetradecanoylphorbol Acetate	36-67	catenin beta 1	Homo sapiens	131-143
3609441-1	1987	12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC, EC 4.1.1.17) in normal, preneoplastic and malignant rat brain cells in culture, but treatment with phorbol, acetate or medium shift resulted in a similar response.	Tetradecanoylphorbol Acetate	39-42	ornithine decarboxylase 1	Rattus norvegicus	52-75
19167408-10	2009	On the contrary, cells treated with phorbol-12-myristate-13-acetate (PMA) had an increase in type II VLDLR expression, whereas the beta-catenin was increased.	Tetradecanoylphorbol Acetate	69-72	very low density lipoprotein receptor	Homo sapiens	101-106
19167408-10	2009	On the contrary, cells treated with phorbol-12-myristate-13-acetate (PMA) had an increase in type II VLDLR expression, whereas the beta-catenin was increased.	Tetradecanoylphorbol Acetate	69-72	catenin beta 1	Homo sapiens	131-143
3609441-1	1987	12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC, EC 4.1.1.17) in normal, preneoplastic and malignant rat brain cells in culture, but treatment with phorbol, acetate or medium shift resulted in a similar response.	Tetradecanoylphorbol Acetate	39-42	ornithine decarboxylase 1	Rattus norvegicus	77-80
17804722-7	2007	Moreover, RSK2(-/-) MEFs accumulated at the G(1) phase of the cell cycle under normal cell culture conditions as well as after stimulation with EGF or TPA.	Tetradecanoylphorbol Acetate	151-154	ribosomal protein S6 kinase polypeptide 3	Mus musculus	10-14
17804722-11	2007	These results showed that RSK2 is a key regulator for cell transformation induced by tumor promoters such as EGF and TPA.	Tetradecanoylphorbol Acetate	117-120	ribosomal protein S6 kinase polypeptide 3	Mus musculus	26-30
19167461-1	2009	Ca(v)2.2 high voltage-gated calcium channels are regulated by phorbol-12-myristae, 13-acetate (PMA) via Ser/Thr protein kinase C (PKC) phosphorylation sites in the I-II linker and C-terminus of the alpha(1) 2.2 subunit.	Tetradecanoylphorbol Acetate	95-98	calcium channel, voltage-dependent, N type, alpha 1B subunit S homeolog	Xenopus laevis	0-8
3332664-5	1987	By treating cells with TPA, intercellular junctions were rapidly disrupted and expression of cytokeratin and desmoplakin was dramatically reduced; however, vimentin expression was not affected.	Tetradecanoylphorbol Acetate	23-26	vimentin	Homo sapiens	156-164
19374880-3	2009	Pretreatment with pitavastatin resulted in a dose-dependent reduction in Egr-1 protein and suppressed Egr-1 mRNA expression in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	139-170	early growth response 1	Homo sapiens	102-107
19374880-3	2009	Pretreatment with pitavastatin resulted in a dose-dependent reduction in Egr-1 protein and suppressed Egr-1 mRNA expression in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	172-175	early growth response 1	Homo sapiens	73-78
19374880-3	2009	Pretreatment with pitavastatin resulted in a dose-dependent reduction in Egr-1 protein and suppressed Egr-1 mRNA expression in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	172-175	early growth response 1	Homo sapiens	102-107
3097147-3	1987	The phorbol ester TPA stimulated ODC activity and [3H]thymidine incorporation to 54% and 31% that of a near-optimal mitogenic concentration of PRL (10 ng/ml), suggesting that mitogenesis in these cells is coupled to some degree to the activation of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	18-21	ornithine decarboxylase 1	Rattus norvegicus	33-36
19124542-6	2009	In contrast, the phorbol ester PMA (phorbol-12-myristate-13-acetate, a pharmacological mimic of the downstream mediator diacylglycerol in alpha-adrenergic signalling), caused continuous PKD-dependent HDAC5-GFP nuclear efflux and maintained PKD1-mPlum redistribution.	Tetradecanoylphorbol Acetate	36-67	polycystin 1, transient receptor potential channel interacting	Mus musculus	240-244
19258426-5	2009	Pretreatment with NSC 676914 is here shown to repress 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IkappaB-alpha phosphorylation and translocation of p65/50 to the nucleus but not the processing of p52 from p100, suggesting the inhibition of NF-kappaB regulator IKKbeta rather than IKKalpha.	Tetradecanoylphorbol Acetate	54-90	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	268-275
19258426-5	2009	Pretreatment with NSC 676914 is here shown to repress 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IkappaB-alpha phosphorylation and translocation of p65/50 to the nucleus but not the processing of p52 from p100, suggesting the inhibition of NF-kappaB regulator IKKbeta rather than IKKalpha.	Tetradecanoylphorbol Acetate	92-95	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	268-275
3099293-5	1987	The expression of MYC and FOS was rapidly induced by the phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	57-88	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-21
3102248-10	1986	Second, with regard to the requirements for receptor expression, it was observed that either anti-Ig or phorbol diester (phorbol-12-myristate 13-acetate) can induce IL 2R and IL 2 responsiveness (proliferation assay) in LPS blasts but not in fresh B cells.	Tetradecanoylphorbol Acetate	121-152	interleukin 2	Mus musculus	165-169
19090773-5	2009	However, activation of protein kinase C by phorbol myristate acetate is able to restore CD3zeta expression and IFN-gamma production.	Tetradecanoylphorbol Acetate	43-68	CD247 molecule	Homo sapiens	88-95
3097128-11	1986	PMA alone induced an IL 2-independent proliferative response.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Mus musculus	21-25
19029835-6	2009	Using the LNCaP orthotopic prostate model it is shown that treatment with TPA or DAG-lactone induces significant reduction in tumor ATM levels coupled with tumor growth delay.	Tetradecanoylphorbol Acetate	74-77	ATM serine/threonine kinase	Homo sapiens	132-135
2945862-4	1986	In a second assay, rIL 1 enhanced proliferation and IL 2 production by 2-4- cells in response to phorbol myristate acetate (PMA) and the calcium ionophore, ionomycin.	Tetradecanoylphorbol Acetate	97-122	interleukin 2	Mus musculus	52-56
19377918-4	2009	Though both tPA and uPA are expressed in tumor cells, uPA with its receptor (uPAR) is mostly involved in cellular functions, while tPA with its receptor Annexin II on endothelial surface, regulates intravascular fibrin deposition.	Tetradecanoylphorbol Acetate	131-134	annexin A2	Homo sapiens	153-163
2945862-4	1986	In a second assay, rIL 1 enhanced proliferation and IL 2 production by 2-4- cells in response to phorbol myristate acetate (PMA) and the calcium ionophore, ionomycin.	Tetradecanoylphorbol Acetate	124-127	interleukin 2	Mus musculus	52-56
3491621-3	1986	CSF responses and macrophage differentiation were induced in KG1 cells by treatment with tetradecanoylphorbol-acetate (TPA).	Tetradecanoylphorbol Acetate	89-117	colony stimulating factor 2	Homo sapiens	0-3
3491621-3	1986	CSF responses and macrophage differentiation were induced in KG1 cells by treatment with tetradecanoylphorbol-acetate (TPA).	Tetradecanoylphorbol Acetate	119-122	colony stimulating factor 2	Homo sapiens	0-3
3491621-6	1986	Induction of CSF response appeared linked to differentiation, since KG1 cells differentiated with TPA and developed CSF-induced proliferative responses, but showed no differentiation or CSF induced proliferation after treatment with vitamin D3.	Tetradecanoylphorbol Acetate	98-101	colony stimulating factor 2	Homo sapiens	13-16
3093072-3	1986	Prolonged incubation with TPA allowed P- cells to regain their original appearance and resulted in growth inhibition; however, the extended presence of TPA produced in P+ cells persistent alterations in the distribution of actin, vinculin, and fibronectin.	Tetradecanoylphorbol Acetate	152-155	fibronectin 1	Mus musculus	244-255
2431900-1	1986	Expression of the myc and fos genes has been monitored in mouse primary keratinocytes after induction of terminal differentiation by calcium or tetradecanoylphorbol acetate (TPA).	Tetradecanoylphorbol Acetate	144-172	FBJ osteosarcoma oncogene	Mus musculus	26-29
2431900-1	1986	Expression of the myc and fos genes has been monitored in mouse primary keratinocytes after induction of terminal differentiation by calcium or tetradecanoylphorbol acetate (TPA).	Tetradecanoylphorbol Acetate	174-177	FBJ osteosarcoma oncogene	Mus musculus	26-29
2431900-5	1986	In contrast to calcium, TPA-induced differentiation is accompanied by dramatic changes in proto-oncogene expression: marked c-fos induction and considerable although transient decrease in c-myc expression.	Tetradecanoylphorbol Acetate	24-27	FBJ osteosarcoma oncogene	Mus musculus	124-129
2431900-6	1986	These effects might be important for the keratinocyte response to TPA: TPA treatment of a keratinocyte cell line (RBK) resistant to this substance has no effect on c-myc expression and leads only to minimal c-fos induction.	Tetradecanoylphorbol Acetate	71-74	FBJ osteosarcoma oncogene	Mus musculus	207-212
2431900-8	1986	Thus, the fos gene in normal keratinocytes is inducible through at least two independent mechanisms, only one of which has been lost during derivation of the TPA-resistant cell line.	Tetradecanoylphorbol Acetate	158-161	FBJ osteosarcoma oncogene	Mus musculus	10-13
2944961-6	1986	The proliferation of HTL in response to PMA + A23187 could be completely inhibited either by cyclosporine A (CsA) or by PC61.5, a monoclonal antibody directed against the murine IL 2 receptor; however, the proliferation of CTL in response to PMA alone was not affected either by CsA or by PC61.5.	Tetradecanoylphorbol Acetate	40-43	interleukin 2	Mus musculus	178-182
2944961-6	1986	The proliferation of HTL in response to PMA + A23187 could be completely inhibited either by cyclosporine A (CsA) or by PC61.5, a monoclonal antibody directed against the murine IL 2 receptor; however, the proliferation of CTL in response to PMA alone was not affected either by CsA or by PC61.5.	Tetradecanoylphorbol Acetate	242-245	interleukin 2	Mus musculus	178-182
3492276-0	1986	Phorbol myristate acetate-induced proliferation of an IL-2-dependent T-cell line: action of PMA is independent of IL-2 and cannot be mimicked by diacylglycerols.	Tetradecanoylphorbol Acetate	0-25	interleukin 2	Mus musculus	54-58
3492276-0	1986	Phorbol myristate acetate-induced proliferation of an IL-2-dependent T-cell line: action of PMA is independent of IL-2 and cannot be mimicked by diacylglycerols.	Tetradecanoylphorbol Acetate	0-25	interleukin 2	Mus musculus	114-118
3492276-1	1986	Phorbol myristate acetate (PMA) at concentrations of 2 X 10(-10) to 2 X 10(-7) M was able to sustain proliferation of the interleukin 2 (IL-2)-dependent murine T-cell line CTLL-K.	Tetradecanoylphorbol Acetate	0-25	interleukin 2	Mus musculus	122-135
3492276-1	1986	Phorbol myristate acetate (PMA) at concentrations of 2 X 10(-10) to 2 X 10(-7) M was able to sustain proliferation of the interleukin 2 (IL-2)-dependent murine T-cell line CTLL-K.	Tetradecanoylphorbol Acetate	0-25	interleukin 2	Mus musculus	137-141
3492276-1	1986	Phorbol myristate acetate (PMA) at concentrations of 2 X 10(-10) to 2 X 10(-7) M was able to sustain proliferation of the interleukin 2 (IL-2)-dependent murine T-cell line CTLL-K.	Tetradecanoylphorbol Acetate	27-30	interleukin 2	Mus musculus	122-135
3492276-1	1986	Phorbol myristate acetate (PMA) at concentrations of 2 X 10(-10) to 2 X 10(-7) M was able to sustain proliferation of the interleukin 2 (IL-2)-dependent murine T-cell line CTLL-K.	Tetradecanoylphorbol Acetate	27-30	interleukin 2	Mus musculus	137-141
3093570-5	1986	Interestingly, the in vitro growth of PMA + ionomycin-stimulated fetal thymocytes appeared to be IL 2 dependent in that it was inhibited by a monoclonal antibody to the IL 2 receptor.	Tetradecanoylphorbol Acetate	38-41	interleukin 2	Mus musculus	97-101
3093570-5	1986	Interestingly, the in vitro growth of PMA + ionomycin-stimulated fetal thymocytes appeared to be IL 2 dependent in that it was inhibited by a monoclonal antibody to the IL 2 receptor.	Tetradecanoylphorbol Acetate	38-41	interleukin 2	Mus musculus	169-173
3530808-0	1986	Activation of S6 kinase activity in astrocytes by insulin, somatomedin C and TPA.	Tetradecanoylphorbol Acetate	77-80	ribosomal protein S6 kinase B1	Rattus norvegicus	14-23
3530808-4	1986	Treatment of these astrocytes with TPA also promoted a rapid increase in S6 kinase activity in the cytosolic fraction.	Tetradecanoylphorbol Acetate	35-38	ribosomal protein S6 kinase B1	Rattus norvegicus	73-82
3490258-2	1986	The normal stimulatory effect of parathyroid hormone and forskolin on 1,25(OH)2D3 production was abolished or blunted by the presence of TPA and TPA overcame the inhibitory effect of PTH and forskolin on 24,25(OH)2D3 production.	Tetradecanoylphorbol Acetate	137-140	parathyroid hormone	Gallus gallus	183-186
3490258-2	1986	The normal stimulatory effect of parathyroid hormone and forskolin on 1,25(OH)2D3 production was abolished or blunted by the presence of TPA and TPA overcame the inhibitory effect of PTH and forskolin on 24,25(OH)2D3 production.	Tetradecanoylphorbol Acetate	145-148	parathyroid hormone	Gallus gallus	183-186
2426097-11	1986	12-O-Tetradecanoylphorbol-13-acetate also enhanced insulin release and the phosphorylation of P19 in these cells.	Tetradecanoylphorbol Acetate	0-36	cyclin dependent kinase inhibitor 2D	Mus musculus	94-97
3732165-2	1986	Sn-1,2-dioctanoylglycerol (diC8) and phorbol-12-myristate-13-acetate (PMA), both of which stimulate placental protein kinase C activity, caused dose-dependent increases in hPL release over a 0.5-h period.	Tetradecanoylphorbol Acetate	37-68	galectin 1	Homo sapiens	172-175
3732165-2	1986	Sn-1,2-dioctanoylglycerol (diC8) and phorbol-12-myristate-13-acetate (PMA), both of which stimulate placental protein kinase C activity, caused dose-dependent increases in hPL release over a 0.5-h period.	Tetradecanoylphorbol Acetate	70-73	galectin 1	Homo sapiens	172-175
3732165-3	1986	The maximal amounts of hPL released in response to diC8 (300 microM) and PMA (10(-8) M) were 200-300% and 150-225% greater, respectively, than that released in response to diluent alone.	Tetradecanoylphorbol Acetate	73-76	galectin 1	Homo sapiens	23-26
3732165-6	1986	After 0.5 h of exposure, diC8 (300 microM)- and PMA (10(-8) M)-exposed cells synthesized 257.5% and 250.3% more hPL than control cells.	Tetradecanoylphorbol Acetate	48-51	galectin 1	Homo sapiens	112-115
2427103-7	1986	C-myc mRNa is detected for up to 36 h after tape stripping, but only for the first hour after TPA application.	Tetradecanoylphorbol Acetate	94-97	myc proto-oncogene protein	Cavia porcellus	2-5
3492504-4	1986	TPA and Ca2+ ionophore, respectively, could also interact synergistically with IL-3 to promote DNA synthesis.	Tetradecanoylphorbol Acetate	0-3	interleukin 3	Homo sapiens	79-83
3488735-1	1986	Colony Stimulating Factor-1 has been purified to apparent homogeneity from the serum-free medium conditioned by cultured human pancreatic carcinoma cells which had been induced with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	182-207	colony stimulating factor 1	Homo sapiens	0-27
3011244-2	1986	A crude supernatant from phorbol myristate acetate exposed EL-4 cells rich in IL-2 plus other lymphokines (EL-4 IL-2), a concanavalin A-induced supernatant from murine splenocytes (Con A IL-2), and recombinant IL-2 (rIL-2) provided by Biogen were tested.	Tetradecanoylphorbol Acetate	25-50	interleukin 2	Mus musculus	78-82
3011244-2	1986	A crude supernatant from phorbol myristate acetate exposed EL-4 cells rich in IL-2 plus other lymphokines (EL-4 IL-2), a concanavalin A-induced supernatant from murine splenocytes (Con A IL-2), and recombinant IL-2 (rIL-2) provided by Biogen were tested.	Tetradecanoylphorbol Acetate	25-50	interleukin 2	Mus musculus	112-116
3011244-2	1986	A crude supernatant from phorbol myristate acetate exposed EL-4 cells rich in IL-2 plus other lymphokines (EL-4 IL-2), a concanavalin A-induced supernatant from murine splenocytes (Con A IL-2), and recombinant IL-2 (rIL-2) provided by Biogen were tested.	Tetradecanoylphorbol Acetate	25-50	interleukin 2	Mus musculus	112-116
3011244-2	1986	A crude supernatant from phorbol myristate acetate exposed EL-4 cells rich in IL-2 plus other lymphokines (EL-4 IL-2), a concanavalin A-induced supernatant from murine splenocytes (Con A IL-2), and recombinant IL-2 (rIL-2) provided by Biogen were tested.	Tetradecanoylphorbol Acetate	25-50	interleukin 2	Mus musculus	112-116
3770042-9	1986	The PCA induced by endotoxin and TPA was identified as tissue factor.	Tetradecanoylphorbol Acetate	33-36	coagulation factor III, tissue factor	Homo sapiens	55-68
2424873-7	1986	Surface marker analysis revealed that the expression of CD2 to CD7 antigens (and also CD25) may be modified following incubation of the TLC with TPA or sodium butyrate but not with 5-azacytidine.	Tetradecanoylphorbol Acetate	145-148	CD2 molecule	Homo sapiens	56-59
3487387-2	1986	Partial purification of TPA-LCM demonstrated the presence of human-active granulocyte-macrophage colony-stimulating factor (GM-CSF; Mr 50-70Kd), macrophage-CSF (M-CSF; Mr greater than 100Kd) and possibly a third protein (Mr 24-26Kd) supporting survival and growth of hematopoietic stem cells in vitro.	Tetradecanoylphorbol Acetate	24-27	colony stimulating factor 2	Homo sapiens	74-122
3487387-2	1986	Partial purification of TPA-LCM demonstrated the presence of human-active granulocyte-macrophage colony-stimulating factor (GM-CSF; Mr 50-70Kd), macrophage-CSF (M-CSF; Mr greater than 100Kd) and possibly a third protein (Mr 24-26Kd) supporting survival and growth of hematopoietic stem cells in vitro.	Tetradecanoylphorbol Acetate	24-27	colony stimulating factor 2	Homo sapiens	124-130
17630204-4	2007	Isoeugenol inhibited phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io)-induced IL-2 mRNA expression and protein secretion in B6C3F1 mouse splenocytes, and in EL4.IL-2 mouse T-cells, as determined by real-time RT-PCR and ELISA, respectively.	Tetradecanoylphorbol Acetate	21-52	interleukin 2	Mus musculus	87-91
3487387-2	1986	Partial purification of TPA-LCM demonstrated the presence of human-active granulocyte-macrophage colony-stimulating factor (GM-CSF; Mr 50-70Kd), macrophage-CSF (M-CSF; Mr greater than 100Kd) and possibly a third protein (Mr 24-26Kd) supporting survival and growth of hematopoietic stem cells in vitro.	Tetradecanoylphorbol Acetate	24-27	colony stimulating factor 1	Homo sapiens	145-159
17630204-4	2007	Isoeugenol inhibited phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io)-induced IL-2 mRNA expression and protein secretion in B6C3F1 mouse splenocytes, and in EL4.IL-2 mouse T-cells, as determined by real-time RT-PCR and ELISA, respectively.	Tetradecanoylphorbol Acetate	21-52	interleukin 2	Mus musculus	170-174
17630204-4	2007	Isoeugenol inhibited phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io)-induced IL-2 mRNA expression and protein secretion in B6C3F1 mouse splenocytes, and in EL4.IL-2 mouse T-cells, as determined by real-time RT-PCR and ELISA, respectively.	Tetradecanoylphorbol Acetate	54-57	interleukin 2	Mus musculus	170-174
3487387-2	1986	Partial purification of TPA-LCM demonstrated the presence of human-active granulocyte-macrophage colony-stimulating factor (GM-CSF; Mr 50-70Kd), macrophage-CSF (M-CSF; Mr greater than 100Kd) and possibly a third protein (Mr 24-26Kd) supporting survival and growth of hematopoietic stem cells in vitro.	Tetradecanoylphorbol Acetate	24-27	colony stimulating factor 1	Homo sapiens	125-130
3009552-10	1986	In contrast to collagenase and collagense inhibitor, TPA-treated U937 cells contained only 10-15% as much elastase and cathepsin G activities as control cells.	Tetradecanoylphorbol Acetate	53-56	cathepsin G	Homo sapiens	119-130
17636002-2	2007	We now show that Cl(-) intracellular channel 4 (CLIC4) expression is increased in both mouse and human keratinocytes undergoing differentiation induced by Ca(2+), serum and the protein kinase C (PKC)-activator, 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	211-248	chloride intracellular channel 4 (mitochondrial)	Mus musculus	48-53
19058267-5	2009	The combination of such large TPA cross-sections and high emission quantum yields, up to 0.94, make these systems attractive for applications involving two-photon excited fluorescence (TPEF).	Tetradecanoylphorbol Acetate	30-33	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	185-189
3082993-1	1986	The murine T lymphoma EL4 subline produces large amounts of interleukin 2 (IL-2) upon stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	103-128	interleukin 2	Mus musculus	60-73
17636002-2	2007	We now show that Cl(-) intracellular channel 4 (CLIC4) expression is increased in both mouse and human keratinocytes undergoing differentiation induced by Ca(2+), serum and the protein kinase C (PKC)-activator, 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	250-253	chloride intracellular channel 4 (mitochondrial)	Mus musculus	48-53
3082993-1	1986	The murine T lymphoma EL4 subline produces large amounts of interleukin 2 (IL-2) upon stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	103-128	interleukin 2	Mus musculus	75-79
3082993-1	1986	The murine T lymphoma EL4 subline produces large amounts of interleukin 2 (IL-2) upon stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	130-133	interleukin 2	Mus musculus	60-73
17476299-9	2007	In conclusion, PMA-induced epidermal thickening and skin IL-1alpha expression were independent of IL-1 signaling, in contrast to dermal inflammation and systemic inflammatory response.	Tetradecanoylphorbol Acetate	15-18	interleukin 1 alpha	Mus musculus	57-66
19273183-4	2009	The fibrotic sequelae caused by increased PAI-1 in kidney depend not only on its classic inhibition of tissue-type and urokinase-type plasminogen activators (tPA and uPA), but also its influence on cell migration.	Tetradecanoylphorbol Acetate	158-161	serpin family E member 1	Homo sapiens	42-47
3082993-1	1986	The murine T lymphoma EL4 subline produces large amounts of interleukin 2 (IL-2) upon stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	130-133	interleukin 2	Mus musculus	75-79
3082993-6	1986	The reverted EL4 cells were again able to produce large amounts of IL-2 upon restimulation with PMA.	Tetradecanoylphorbol Acetate	96-99	interleukin 2	Mus musculus	67-71
3082993-9	1986	PMA appears to act at the level of the expression of the IL-2 gene, since IL-2 mRNA was much more abundant in the IL-2-secreting PMA-treated cells than in untreated controls.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Mus musculus	57-61
19001787-6	2009	RESULTS: The application of TPA shifted the PiCl-induced allergic inflammation from a delayed-type response to a biphasic response, increased the infiltration of eosinophils and mast cells at the inflammatory site, shifted the cytokine milieu from Th1 to Th2 and induced the expression of thymic stromal lymphopoietin in the ear lobes.	Tetradecanoylphorbol Acetate	28-31	heart and neural crest derivatives expressed 2	Mus musculus	255-258
17553897-6	2007	In human TPA-differentiated HL-60 cells, which are macrophage-like cells, LPS-induced MOR mRNA up-regulation was greater in gp120-pretreated cells than in vehicle-pretreated cells.	Tetradecanoylphorbol Acetate	9-12	opioid receptor mu 1	Homo sapiens	86-89
3082993-9	1986	PMA appears to act at the level of the expression of the IL-2 gene, since IL-2 mRNA was much more abundant in the IL-2-secreting PMA-treated cells than in untreated controls.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Mus musculus	74-78
3082993-9	1986	PMA appears to act at the level of the expression of the IL-2 gene, since IL-2 mRNA was much more abundant in the IL-2-secreting PMA-treated cells than in untreated controls.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Mus musculus	74-78
17566751-4	2007	In this report, we studied the regulation of tPA activity in vivo during ageing in normal mice and in a mouse model of AD characterized by an exacerbated endogenous Abeta accumulation.	Tetradecanoylphorbol Acetate	45-48	amyloid beta (A4) precursor protein	Mus musculus	165-170
3005408-4	1986	This response, which is also induced by phorbol myristate acetate and lipolysaccharide, is detectable within 1 min of mIg cross-linking and is followed within 4 min by additional translocation of PKCa to a Triton-insoluble particulate compartment.	Tetradecanoylphorbol Acetate	40-65	chemokine (C-X-C motif) ligand 9	Mus musculus	118-121
17566751-5	2007	We observed that cerebral tPA activity was decreased during ageing in normal mice and that this effect was worsened in mice overproducing Abeta peptides.	Tetradecanoylphorbol Acetate	26-29	amyloid beta (A4) precursor protein	Mus musculus	138-143
17566751-6	2007	These phenomena result, respectively, from a decrease in tPA expression and from an increase in the production of one of the tPA inhibitors, the plasminogen activator inhibitor type 1 (PAI-1).	Tetradecanoylphorbol Acetate	125-128	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	145-183
19309550-7	2009	Immunofluorescence data show that ST1959 inhibits the nuclear residency of NFAT1 in both Jurkat and human peripheral blood mononuclear cells activated with PMA/ionomycin.	Tetradecanoylphorbol Acetate	156-159	nuclear factor of activated T cells 2	Homo sapiens	75-80
17566751-6	2007	These phenomena result, respectively, from a decrease in tPA expression and from an increase in the production of one of the tPA inhibitors, the plasminogen activator inhibitor type 1 (PAI-1).	Tetradecanoylphorbol Acetate	125-128	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	185-190
3081905-4	1986	We found that these "double-negative" thymocytes were unresponsive to Con A plus PMA but produced substantial amounts of IL-2 when stimulated with A23187 plus PMA.	Tetradecanoylphorbol Acetate	159-162	interleukin 2	Mus musculus	121-125
17566751-7	2007	A similar study in sporadic AD and age-matched control brain tissues revealed that the tPA proteolytic activity was negatively correlated to Abeta peptides levels supporting the data observed in mice.	Tetradecanoylphorbol Acetate	87-90	amyloid beta (A4) precursor protein	Mus musculus	141-146
19082507-1	2009	Wild-type plasminogen activator inhibitor type 1 (PAI-1) is a fast-acting uPA and tPA inhibitor with half-life of 1-2 h. Recombinant PAI-1 with two mutations, Q197C and G355C, shows a very long half-life (VLHL).	Tetradecanoylphorbol Acetate	82-85	serpin family E member 1	Homo sapiens	10-48
19082507-1	2009	Wild-type plasminogen activator inhibitor type 1 (PAI-1) is a fast-acting uPA and tPA inhibitor with half-life of 1-2 h. Recombinant PAI-1 with two mutations, Q197C and G355C, shows a very long half-life (VLHL).	Tetradecanoylphorbol Acetate	82-85	serpin family E member 1	Homo sapiens	50-55
19082507-1	2009	Wild-type plasminogen activator inhibitor type 1 (PAI-1) is a fast-acting uPA and tPA inhibitor with half-life of 1-2 h. Recombinant PAI-1 with two mutations, Q197C and G355C, shows a very long half-life (VLHL).	Tetradecanoylphorbol Acetate	82-85	serpin family E member 1	Homo sapiens	133-138
18757500-8	2008	In contrast, phorbol 12-myristate-13-acetate (TPA) -induced cleavage of HB-EGF, NRG, and TGF-alpha was dependent on PKC and sensitive to BB94 inhibition.	Tetradecanoylphorbol Acetate	46-49	heparin-binding EGF-like growth factor	Mus musculus	72-78
18719353-8	2008	These results suggest that the activation of two distinct pathways such as Ras-Raf-ERK-TCF pathway and Rho-SRF pathway are responsible for the induction of c-fos by TPA and Ras in mitogenic signaling pathways.	Tetradecanoylphorbol Acetate	165-168	FBJ osteosarcoma oncogene	Mus musculus	156-161
17522053-7	2007	AQP1 cationic currents measured with double-electrode voltage clamp were markedly increased after pharmacological activation of PKC by either OAG or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	149-180	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	0-4
17355247-6	2007	Moreover, leptin decreased the percentage of CD4(+) and CD8(+) cells producing IL-4 and IL-10, and enhanced activation of circulating T cells when co-stimulated by phorbol 12-myristate 13 acetate (PMA)-ionomycin.	Tetradecanoylphorbol Acetate	164-195	leptin	Homo sapiens	10-16
3484478-5	1986	The tumor promoter 12-O-tetradecanoylphorbol 13-acetate completely inhibits the EGF- and serum-induced increases in [Ca2+]i without affecting basal [Ca2+]i levels.	Tetradecanoylphorbol Acetate	19-55	epidermal growth factor	Homo sapiens	80-83
17355247-6	2007	Moreover, leptin decreased the percentage of CD4(+) and CD8(+) cells producing IL-4 and IL-10, and enhanced activation of circulating T cells when co-stimulated by phorbol 12-myristate 13 acetate (PMA)-ionomycin.	Tetradecanoylphorbol Acetate	197-200	leptin	Homo sapiens	10-16
18684713-6	2008	Glutamate transport assay revealed that increasing the expression of Arl6ip1 in C6BU-1 cells markedly enhanced Na+-dependent EAAC1-mediated glutamate transport activity in the presence of 100 nm phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	195-226	ADP-ribosylation factor like GTPase 6 interacting protein 1	Rattus norvegicus	69-76
3096504-1	1986	After stimulation of human lymphocytes by 12-0 tetradecanoyl phorbol acetate (TPA) and by the calcium ionophore A23187 an early transient expression of proto-oncogene fos followed by an expression of c-myc is observed, as has been described in rodent fibroblast stimulated by growth factors.	Tetradecanoylphorbol Acetate	78-81	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	200-205
18775730-1	2008	Deleted in Split hand/Split foot 1 (DSS1) was previously identified as a novel 12-O-tetradecanoylphorbol-13-acetate (TPA)-inducible gene with possible involvement in early event of mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	79-115	SEM1 26S proteasome subunit	Homo sapiens	36-40
18775730-1	2008	Deleted in Split hand/Split foot 1 (DSS1) was previously identified as a novel 12-O-tetradecanoylphorbol-13-acetate (TPA)-inducible gene with possible involvement in early event of mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	117-120	SEM1 26S proteasome subunit	Homo sapiens	36-40
17408801-8	2007	IRS-4 down-regulation abolished IGF-I-, TPA- and IGF-I plus TPA-stimulated ERK and p70S6K activities.	Tetradecanoylphorbol Acetate	40-43	ribosomal protein S6 kinase B1	Homo sapiens	83-89
17408801-8	2007	IRS-4 down-regulation abolished IGF-I-, TPA- and IGF-I plus TPA-stimulated ERK and p70S6K activities.	Tetradecanoylphorbol Acetate	60-63	insulin receptor substrate 4	Homo sapiens	0-5
17408801-8	2007	IRS-4 down-regulation abolished IGF-I-, TPA- and IGF-I plus TPA-stimulated ERK and p70S6K activities.	Tetradecanoylphorbol Acetate	60-63	ribosomal protein S6 kinase B1	Homo sapiens	83-89
3001707-5	1985	PMA also inhibited LH receptor induction by cholera toxin, forskolin, and 8-bromo-cAMP, but it did not impair cAMP responses to the former two agents, indicating that the site of action of the phorbol ester is distal to adenylate cyclase.	Tetradecanoylphorbol Acetate	0-3	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	19-30
17498119-10	2007	In HD patients, resistin correlated significantly, in univariate analysis, with calcium, phosphate, PTH, TIBC, vWF residual renal function, urea, hsCRP, IL-6 and tended to correlate with tPA and ferritin.	Tetradecanoylphorbol Acetate	187-190	resistin	Homo sapiens	16-24
18691680-8	2008	The activity of cysteine proteinases as assessed in bone extracts, proved to be higher in extracts from uPA/tPA(-/-) bones.	Tetradecanoylphorbol Acetate	108-111	plasminogen activator, urokinase	Mus musculus	104-107
3879111-0	1985	Phorbol myristate acetate--fate and usability in a human interleukin-1 assay.	Tetradecanoylphorbol Acetate	0-25	interleukin 1 alpha	Homo sapiens	57-70
18780286-4	2008	Hepatocyte or epidermal growth factor (EGF), or phorbol 12-myristate 13-acetate induced UCP expression following early induction of Egr-1 expression in HeLa cells.	Tetradecanoylphorbol Acetate	48-79	uncoupling protein 1	Homo sapiens	88-91
17376781-3	2007	In HEK-293 cells stably expressing CaR (CaR-HEK), but not in cells expressing the mutant receptor CaR(T888A), phorbol ester (PMA) treatment increased CaR(pT888) immunoreactivity as observed by immunoblotting and immunofluorescence.	Tetradecanoylphorbol Acetate	125-128	CXADR pseudogene 1	Homo sapiens	35-38
17376781-3	2007	In HEK-293 cells stably expressing CaR (CaR-HEK), but not in cells expressing the mutant receptor CaR(T888A), phorbol ester (PMA) treatment increased CaR(pT888) immunoreactivity as observed by immunoblotting and immunofluorescence.	Tetradecanoylphorbol Acetate	125-128	CXADR pseudogene 1	Homo sapiens	40-43
3879111-1	1985	Phorbol myristate acetate (PMA) has been widely used to produce interleukin-1 (IL-1) from monocytes (Mo) of various species, including man.	Tetradecanoylphorbol Acetate	0-25	interleukin 1 alpha	Homo sapiens	64-77
17376781-3	2007	In HEK-293 cells stably expressing CaR (CaR-HEK), but not in cells expressing the mutant receptor CaR(T888A), phorbol ester (PMA) treatment increased CaR(pT888) immunoreactivity as observed by immunoblotting and immunofluorescence.	Tetradecanoylphorbol Acetate	125-128	CXADR pseudogene 1	Homo sapiens	40-43
3879111-1	1985	Phorbol myristate acetate (PMA) has been widely used to produce interleukin-1 (IL-1) from monocytes (Mo) of various species, including man.	Tetradecanoylphorbol Acetate	0-25	interleukin 1 alpha	Homo sapiens	79-83
18800802-3	2008	TPA was topically applied to the shaven backs of ICR mice with or without CS (1 or 2 mg) for 4 h. The results demonstrated that CS suppressed TPA-induced edema and reduced the expression of cyclooxygenase-2, vascular cell adhesion molecule-1, and Akt signaling in mouse skin.	Tetradecanoylphorbol Acetate	0-3	vascular cell adhesion molecule 1	Mus musculus	208-241
3879111-1	1985	Phorbol myristate acetate (PMA) has been widely used to produce interleukin-1 (IL-1) from monocytes (Mo) of various species, including man.	Tetradecanoylphorbol Acetate	27-30	interleukin 1 alpha	Homo sapiens	64-77
3879111-1	1985	Phorbol myristate acetate (PMA) has been widely used to produce interleukin-1 (IL-1) from monocytes (Mo) of various species, including man.	Tetradecanoylphorbol Acetate	27-30	interleukin 1 alpha	Homo sapiens	79-83
17359938-5	2007	In contrast, the application of 1 microM phorbol 12-myristate 13-acetate in normoxia cardiomyocytes preserved the pH(i) during I/R, which was similar to that in IHA cardiomyocytes.	Tetradecanoylphorbol Acetate	41-72	glucose-6-phosphate isomerase	Rattus norvegicus	114-119
3879111-2	1985	Supernatants from cultures of human Mo, stimulated with PMA, 2 X 10(-6) M, contained IL-1-like activity, as judged by their high co-mitogenic effect on mitogen-stimulated human T-cells.	Tetradecanoylphorbol Acetate	56-59	interleukin 1 alpha	Homo sapiens	85-89
17448503-6	2007	The application of MEK1 inhibitor PD98059 upon TPA treatment blocked the TPA-induced decrease of NPM/B23 protein and aborted the megakaryocytic differentiation but not to break through the cell growth arrest.	Tetradecanoylphorbol Acetate	47-50	mitogen-activated protein kinase kinase 1	Homo sapiens	19-23
17448503-6	2007	The application of MEK1 inhibitor PD98059 upon TPA treatment blocked the TPA-induced decrease of NPM/B23 protein and aborted the megakaryocytic differentiation but not to break through the cell growth arrest.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase kinase 1	Homo sapiens	19-23
18619673-6	2008	In contrast, PMA treatment (but not forskolin) resulted in a 2-fold increase in production of galanin and somatostatin, and a 3-fold increase in NPY production.	Tetradecanoylphorbol Acetate	13-16	neuropeptide Y	Homo sapiens	145-148
3879111-4	1985	By way of 3H-PMA it was demonstrated that the IL-1-like effect of PMA-induced supernatants was non-dialyzable, was coupled to proteins with a molecular weight greater than 70,000 Dalton and could be dependent mainly upon the PMA content.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 alpha	Homo sapiens	46-50
18757399-3	2008	Fos-dependent transcription of selected genes was confirmed by quantitative real-time PCR analysis using tumor samples and mouse back skin treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	171-207	FBJ osteosarcoma oncogene	Mus musculus	0-3
3879111-4	1985	By way of 3H-PMA it was demonstrated that the IL-1-like effect of PMA-induced supernatants was non-dialyzable, was coupled to proteins with a molecular weight greater than 70,000 Dalton and could be dependent mainly upon the PMA content.	Tetradecanoylphorbol Acetate	66-69	interleukin 1 alpha	Homo sapiens	46-50
18757399-3	2008	Fos-dependent transcription of selected genes was confirmed by quantitative real-time PCR analysis using tumor samples and mouse back skin treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	209-212	FBJ osteosarcoma oncogene	Mus musculus	0-3
18757399-6	2008	Direct Fos protein binding to the Pdpn promoter was shown by chromatin immunoprecipitation and a TPA-induced complex at a TPA-responsive element-like motif in the proximal promoter was identified by electrophoretic mobility shift assays.	Tetradecanoylphorbol Acetate	97-100	podoplanin	Mus musculus	34-38
3932189-5	1985	The cells rendered IL-2-responsive by PMA are enriched in the more mature peanut agglutinin (PNA)-negative population.	Tetradecanoylphorbol Acetate	38-41	interleukin 2	Mus musculus	19-23
18477669-3	2008	In primary human nasal epithelial cells, treatment with TPA led not only to activation of phosphorylation of PKC, myristoylated alanine-rich C kinase substrate, and mitogen-activated protein kinase but also expression of novel PKC-delta, PKC-theta, and PKC-epsilon.	Tetradecanoylphorbol Acetate	56-59	protein kinase C epsilon	Homo sapiens	253-264
2995448-14	1985	MPO levels also fell in the AT-treated injured animals from 16.59 to 0.85 delta OD/min X ml in FNLP animals in the absence and presence of AT, and 30.47 to 0.60 delta OD/min X ml in PMA-treated animals.	Tetradecanoylphorbol Acetate	182-185	myeloperoxidase	Macaca mulatta	0-3
18641637-1	2008	Mice that lack JunB in epidermal cells are born with normal skin; however, keratinocytes hyperproliferate in vitro and on TPA treatment in vivo.	Tetradecanoylphorbol Acetate	122-125	jun B proto-oncogene	Mus musculus	15-19
18534741-3	2008	The use of PMA for 15 min-activated PKCepsilon and ERK1/2, whereas incubation with PMA for 3 h induced PKCalpha activation and attenuated the PMA-triggered phosphorylation of ERK1/2.	Tetradecanoylphorbol Acetate	11-14	protein kinase C epsilon	Homo sapiens	36-46
16860414-3	2007	METHODS AND RESULTS: Through TaqMan real-time RT-PCR and Western blotting, we found the expression of both EMMPRIN mRNA and protein was significantly increased during phorbol 12-myristate 13-acetate (PMA)-induced monocyte differentiation into macrophages.	Tetradecanoylphorbol Acetate	167-198	basigin (Ok blood group)	Homo sapiens	107-114
16860414-3	2007	METHODS AND RESULTS: Through TaqMan real-time RT-PCR and Western blotting, we found the expression of both EMMPRIN mRNA and protein was significantly increased during phorbol 12-myristate 13-acetate (PMA)-induced monocyte differentiation into macrophages.	Tetradecanoylphorbol Acetate	200-203	basigin (Ok blood group)	Homo sapiens	107-114
17483328-7	2007	Chronic exposure to TPA revealed that CD34KO skin developed and sustained epidermal hyperplasia.	Tetradecanoylphorbol Acetate	20-23	CD34 antigen	Mus musculus	38-42
3860288-1	1985	Tumor-promoting phorbol esters including 12-O-tetradecanoylphorbol-13-acetate (TPA), specific inhibitors for erythroid differentiation in mouse Friend cells, induce a newly identified nuclear protein with a molecular weight of 54,000 (p54) in Friend cells.	Tetradecanoylphorbol Acetate	41-77	interferon-induced protein with tetratricopeptide repeats 2	Mus musculus	235-238
17483328-10	2007	These data show that CD34 is required for TPA-induced hair follicle stem cell activation and tumor formation in mice.	Tetradecanoylphorbol Acetate	42-45	CD34 antigen	Mus musculus	21-25
18425423-7	2008	Significant increase in the protein levels of c-jun, p65, and p53 by ELISA were observed in DMBA/TPA treated mice tumors whereas less expression was observed in LA and LAM treated tumors.	Tetradecanoylphorbol Acetate	97-100	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	53-56
18425423-7	2008	Significant increase in the protein levels of c-jun, p65, and p53 by ELISA were observed in DMBA/TPA treated mice tumors whereas less expression was observed in LA and LAM treated tumors.	Tetradecanoylphorbol Acetate	97-100	transformation related protein 53, pseudogene	Mus musculus	62-65
3860288-1	1985	Tumor-promoting phorbol esters including 12-O-tetradecanoylphorbol-13-acetate (TPA), specific inhibitors for erythroid differentiation in mouse Friend cells, induce a newly identified nuclear protein with a molecular weight of 54,000 (p54) in Friend cells.	Tetradecanoylphorbol Acetate	79-82	interferon-induced protein with tetratricopeptide repeats 2	Mus musculus	235-238
17339358-8	2007	Similar down modulation of IFN-gammaR1 protein and mRNA expression in phorbol myristate acetate-differentiated THP-1 cells (pdTHP-1) by M. tuberculosis was observed (P &lt; 0.01).	Tetradecanoylphorbol Acetate	70-95	interferon gamma receptor 1	Homo sapiens	27-38
3860288-3	1985	In a variant cell line of Friend cells which exhibits resistance to TPA in erythroid differentiation, p54 was not induced by TPA.	Tetradecanoylphorbol Acetate	68-71	interferon-induced protein with tetratricopeptide repeats 2	Mus musculus	102-105
18287572-5	2008	In vitro studies with primary mouse granulosa cells document that Adam8 is induced in response to forskolin (Fo) and phorbol ester (PMA) or Fo and Amphiregulin treatment.	Tetradecanoylphorbol Acetate	132-135	a disintegrin and metallopeptidase domain 8	Mus musculus	66-71
3860288-4	1985	The induction of p54 by TPA was counteracted by erythroid-inducing agents including dimethyl sulfoxide, hexamethylenebisacetamide, and actinomycin D.	Tetradecanoylphorbol Acetate	24-27	interferon-induced protein with tetratricopeptide repeats 2	Mus musculus	17-20
17400803-6	2007	Inhibition of ERK1/2 activity by U0126 decreased PMA-treated StAR expression but increased dbcAMP/hCG-mediated StAR and P-StAR; however, progesterone levels were attenuated.	Tetradecanoylphorbol Acetate	49-52	steroidogenic acute regulatory protein	Mus musculus	61-65
4040399-0	1985	In vivo induction of rat hepatic ornithine decarboxylase and plasminogen activator by 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	86-122	ornithine decarboxylase 1	Rattus norvegicus	33-56
17409634-7	2007	A protein kinase C (PKC) activator, phorbol-12-myristate-13-acetate, increased H1R mRNA expression, whereas an activator of PKA or PKG (8-Br-cAMP or 8-Br-cGMP, respectively) did not.	Tetradecanoylphorbol Acetate	36-67	histamine receptor H1	Homo sapiens	79-82
16950795-8	2007	9Z,11E-CLA treatment down-regulated phosphorylation and catalytic activities of IKKalpha/beta in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	97-100	conserved helix-loop-helix ubiquitous kinase	Mus musculus	80-93
18463134-5	2008	In contrast to the inhibition of transcription by JDP2, JDP2-CHOP complex strongly enhances transcription from promoters containing TPA response elements (TRE), but not from those containing cyclic AMP response elements (CRE).	Tetradecanoylphorbol Acetate	132-135	Jun dimerization protein 2	Homo sapiens	56-60
18289624-10	2008	TF production was also impaired by OTA (1 mug/ml) when MNC were stimulated with phorbol myristate acetate (98% inhibition), IL-1beta (83%) or TNF-alpha (62%).	Tetradecanoylphorbol Acetate	80-105	coagulation factor III, tissue factor	Homo sapiens	0-2
4040399-4	1985	It is concluded that: (1) systemic TPA rapidly induces plasminogen activator and ornithine decarboxylase activities in rat liver; and (2) both inductions reflect de novo enzyme synthesis.	Tetradecanoylphorbol Acetate	35-38	ornithine decarboxylase 1	Rattus norvegicus	81-104
18072286-3	2008	The 2MeSADP-mediated biphasic Ca(2+) signals were inhibited by phospholipase C (PLC) inhibitor U73122, and completely blocked by P2Y(1) selective antagonist MRS2179 and protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) whereas enhanced by PKC inhibitors GF109203X and Go6979.	Tetradecanoylphorbol Acetate	202-233	purinergic receptor P2Y1	Homo sapiens	129-135
4033660-0	1985	Altered beta-actin gene expression in phorbol myristate acetate-treated chondrocytes and fibroblasts.	Tetradecanoylphorbol Acetate	38-63	actin, beta	Gallus gallus	8-18
18483307-3	2008	Elevation of HO-1 gene expression by ferric protoporphyrin IX inhibited TPA-induced invasion of MCF-7 cells, which was blocked by adding the heme oxygenase inhibitor, tin protoporphyrin IX, or transfection of cells with HO-1 short hairpin RNA.	Tetradecanoylphorbol Acetate	72-75	heme oxygenase 1	Homo sapiens	13-17
18483307-3	2008	Elevation of HO-1 gene expression by ferric protoporphyrin IX inhibited TPA-induced invasion of MCF-7 cells, which was blocked by adding the heme oxygenase inhibitor, tin protoporphyrin IX, or transfection of cells with HO-1 short hairpin RNA.	Tetradecanoylphorbol Acetate	72-75	heme oxygenase 1	Homo sapiens	220-224
18483307-4	2008	MCF-7 cells overexpressing HO-1 (MCF-7/HO-1) were established in the present study, and TPA-induced MMP-9 gene expression, tumor invasion, and colony formation were significantly reduced in MCF-7/HO-1 cells, compared with those in Neo-transfected cells.	Tetradecanoylphorbol Acetate	88-91	heme oxygenase 1	Homo sapiens	27-31
17196728-4	2007	In the present study the effects of protocatechuic acid, chlorogenic acid and tannic acid on TPA-stimulated PKC isozymes alpha, beta(1), beta(2), gamma and zeta activity, and their distribution in mouse epidermis, was examined.	Tetradecanoylphorbol Acetate	93-96	hemoglobin, beta adult major chain	Mus musculus	128-135
18483307-4	2008	MCF-7 cells overexpressing HO-1 (MCF-7/HO-1) were established in the present study, and TPA-induced MMP-9 gene expression, tumor invasion, and colony formation were significantly reduced in MCF-7/HO-1 cells, compared with those in Neo-transfected cells.	Tetradecanoylphorbol Acetate	88-91	heme oxygenase 1	Homo sapiens	33-43
4033660-1	1985	Phorbol-12-myristate-13-acetate (PMA), a potent tumor promoter, was shown to have opposite effects on the cellular morphology and steady-state levels of beta-actin mRNA in embryonic chicken muscle fibroblasts and sternal chondrocytes.	Tetradecanoylphorbol Acetate	0-31	actin, beta	Gallus gallus	153-163
18483307-4	2008	MCF-7 cells overexpressing HO-1 (MCF-7/HO-1) were established in the present study, and TPA-induced MMP-9 gene expression, tumor invasion, and colony formation were significantly reduced in MCF-7/HO-1 cells, compared with those in Neo-transfected cells.	Tetradecanoylphorbol Acetate	88-91	heme oxygenase 1	Homo sapiens	39-43
4033660-1	1985	Phorbol-12-myristate-13-acetate (PMA), a potent tumor promoter, was shown to have opposite effects on the cellular morphology and steady-state levels of beta-actin mRNA in embryonic chicken muscle fibroblasts and sternal chondrocytes.	Tetradecanoylphorbol Acetate	33-36	actin, beta	Gallus gallus	153-163
18483307-5	2008	Activation of protein kinase Calpha/extracellular signal-regulated kinases/AP-1 with stimulation of reactive oxygen species production was involved in TPA-induced invasion of MCF-7 cells, which was attenuated by HO-1 protein induced by ferric protoporphyrin IX or transfection of HO-1 expression vectors.	Tetradecanoylphorbol Acetate	151-154	heme oxygenase 1	Homo sapiens	212-216
17091491-4	2007	Similarly, overexpression of PKCepsilon increased the differentiation of astrocytes and a PKCepsilonKD mutant abolished PMA effect.	Tetradecanoylphorbol Acetate	120-123	protein kinase C epsilon	Homo sapiens	29-39
18483307-5	2008	Activation of protein kinase Calpha/extracellular signal-regulated kinases/AP-1 with stimulation of reactive oxygen species production was involved in TPA-induced invasion of MCF-7 cells, which was attenuated by HO-1 protein induced by ferric protoporphyrin IX or transfection of HO-1 expression vectors.	Tetradecanoylphorbol Acetate	151-154	heme oxygenase 1	Homo sapiens	280-284
17091491-5	2007	PMA phosphorylates PKCepsilon on serine 729.	Tetradecanoylphorbol Acetate	0-3	protein kinase C epsilon	Homo sapiens	19-29
4033660-2	1985	When fibroblasts were treated with PMA, they formed foci of densely packed cells, ceased to adhere to culture plates, and had significantly reduced levels of beta-actin mRNA and protein.	Tetradecanoylphorbol Acetate	35-38	actin, beta	Gallus gallus	163-168
18204848-6	2008	In the present study, we sought to determine whether the cytokine interleukin-1alpha (IL-1alpha) and its regulator transforming growth factor beta1 (TGF-beta1), which are both commonly present in skin wounds, influence tPA production in cultured murine epidermal keratinocytes.	Tetradecanoylphorbol Acetate	219-222	interleukin 1 alpha	Mus musculus	66-84
3159569-8	1985	We observed strong induction of c-fos and to a lesser extent of c-myc also by TPA, and by the calcium ionophore A23187, indicating an important role for kinase C in proto-oncogene activation by growth factors.	Tetradecanoylphorbol Acetate	78-81	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	64-69
18204848-6	2008	In the present study, we sought to determine whether the cytokine interleukin-1alpha (IL-1alpha) and its regulator transforming growth factor beta1 (TGF-beta1), which are both commonly present in skin wounds, influence tPA production in cultured murine epidermal keratinocytes.	Tetradecanoylphorbol Acetate	219-222	interleukin 1 alpha	Mus musculus	86-95
18204848-7	2008	We treated the keratinocytes with IL-1alpha in the absence or presence of TGF-beta1 at various concentrations and analyzed the expression of tPA by RT-PCR, in situ hybridization, immunocytochemistry as well as immunofluorescence.	Tetradecanoylphorbol Acetate	141-144	interleukin 1 alpha	Mus musculus	34-43
18204848-8	2008	We found that IL-1alpha induced mRNA and protein expression of tPA in a time and dose dependent manners.	Tetradecanoylphorbol Acetate	63-66	interleukin 1 alpha	Mus musculus	14-23
18204848-10	2008	However, treatment of keratinocytes with TGF-beta1 partially inhibited IL-1alpha induced expression of tPA mRNA in dose dependent manners and the maximal inhibition was seen at 60 ng/ml.	Tetradecanoylphorbol Acetate	103-106	interleukin 1 alpha	Mus musculus	71-80
18204848-11	2008	Our findings could explain tPA generation in wound epidermis is at least partially controlled by changes in local IL-1alpha activity, and will contribute to our understanding the physiological effects of IL-1alpha and TGF-beta1 as well as their interaction of with the PA system during skin wound healing.	Tetradecanoylphorbol Acetate	27-30	interleukin 1 alpha	Mus musculus	114-123
16774932-3	2007	PMA selectively causes the degradation of IkappaB kinases (IKKs) including IKK-gamma and IKK-beta, and subsequent inhibition of tumor necrosis factor (TNF) induced IKK and NF-kappaB activation in human colon cancer cell line HCT-116, but not in other gastrointestinal tract cells.	Tetradecanoylphorbol Acetate	0-3	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	75-84
16774932-3	2007	PMA selectively causes the degradation of IkappaB kinases (IKKs) including IKK-gamma and IKK-beta, and subsequent inhibition of tumor necrosis factor (TNF) induced IKK and NF-kappaB activation in human colon cancer cell line HCT-116, but not in other gastrointestinal tract cells.	Tetradecanoylphorbol Acetate	0-3	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	89-97
18204848-11	2008	Our findings could explain tPA generation in wound epidermis is at least partially controlled by changes in local IL-1alpha activity, and will contribute to our understanding the physiological effects of IL-1alpha and TGF-beta1 as well as their interaction of with the PA system during skin wound healing.	Tetradecanoylphorbol Acetate	27-30	interleukin 1 alpha	Mus musculus	204-213
2982592-9	1985	TPA interacted with EGF by reducing the affinity of membrane receptors for [125I]iodo-EGF.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor	Homo sapiens	20-23
18337662-12	2008	CONCLUSION: Although graft PAI-1 uptake inhibits tPA activity, graft releases D-dimer at early reperfusion without concomitant F1+2 release.	Tetradecanoylphorbol Acetate	49-52	serpin family E member 1	Homo sapiens	27-32
18220793-4	2007	Annexin II is one of the well studied receptors for plasminogen and tPA, which binds to plasminogen and converts it to plasmin.	Tetradecanoylphorbol Acetate	68-71	annexin A2	Homo sapiens	0-10
2982592-9	1985	TPA interacted with EGF by reducing the affinity of membrane receptors for [125I]iodo-EGF.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor	Homo sapiens	86-89
2982592-10	1985	Although the alteration in EGF-receptor interaction induced by TPA may play a role in mediating TPA"s biological effects, the additive effects of TPA and EGF on iodine metabolism suggest that TPA does not act solely through the EGF receptor-effector system.	Tetradecanoylphorbol Acetate	63-66	epidermal growth factor	Homo sapiens	27-30
18288394-5	2008	Our data show that the expression of the BTG2 gene was increased in 32 nM TPA-treated and 1 microM RA-treated HL-60 cells, but the expression of the BTG1 and BTG3 genes was not increased.	Tetradecanoylphorbol Acetate	74-77	BTG anti-proliferation factor 2	Homo sapiens	41-45
2982592-10	1985	Although the alteration in EGF-receptor interaction induced by TPA may play a role in mediating TPA"s biological effects, the additive effects of TPA and EGF on iodine metabolism suggest that TPA does not act solely through the EGF receptor-effector system.	Tetradecanoylphorbol Acetate	96-99	epidermal growth factor	Homo sapiens	27-30
16850107-11	2007	TPA stimulation showed that MMP-1 and -9 transcription was inducible on the mRNA and protein level in 231-parental but not in 231-brain or -bone.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 1	Homo sapiens	28-40
2982592-10	1985	Although the alteration in EGF-receptor interaction induced by TPA may play a role in mediating TPA"s biological effects, the additive effects of TPA and EGF on iodine metabolism suggest that TPA does not act solely through the EGF receptor-effector system.	Tetradecanoylphorbol Acetate	96-99	epidermal growth factor	Homo sapiens	27-30
2982592-10	1985	Although the alteration in EGF-receptor interaction induced by TPA may play a role in mediating TPA"s biological effects, the additive effects of TPA and EGF on iodine metabolism suggest that TPA does not act solely through the EGF receptor-effector system.	Tetradecanoylphorbol Acetate	96-99	epidermal growth factor	Homo sapiens	27-30
3990681-2	1985	We report here the molecular cloning of the cDNA encoding this protein and demonstrate that its induction is a consequence of enhanced mRNA levels for major excreted protein in both tetradecanoyl phorbol acetate-treated 3T3 cells and 3T3 cells transformed by a variety of retroviruses or retroviral oncogenes.	Tetradecanoylphorbol Acetate	182-211	cathepsin L	Mus musculus	151-173
17200786-0	2007	IL-4 modulates tissue factor expression by human B lymphocytes in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	78-103	coagulation factor III, tissue factor	Homo sapiens	15-28
18164258-2	2008	It has been reported that c-Cbl and Cbl-b mRNAs are up-regulated during TPA-induced U937 and HL-60 cell differentiation.	Tetradecanoylphorbol Acetate	72-75	Cbl proto-oncogene	Homo sapiens	26-31
18164258-2	2008	It has been reported that c-Cbl and Cbl-b mRNAs are up-regulated during TPA-induced U937 and HL-60 cell differentiation.	Tetradecanoylphorbol Acetate	72-75	Cbl proto-oncogene B	Homo sapiens	36-41
18070609-6	2008	Finally, repression of TPA-dependent Prx I induction by LPS was mediated via Bruton"s tyrosine kinase as indicated by studies with the pharmacological inhibitor LFM-A13.	Tetradecanoylphorbol Acetate	23-26	peroxiredoxin 1	Homo sapiens	37-42
17069861-4	2006	Furthermore, phorbol myristate acetate (PMA), a PKC stimulant, but not dibutyryl cyclic AMP, a protein kinase A stimulant, decreased the levels of HSP27.	Tetradecanoylphorbol Acetate	13-38	heat shock protein family B (small) member 1	Homo sapiens	147-152
18070609-7	2008	In summary, LPS-dependent inhibition of Prx I gene activation by TPA in monocytes is regulated via a pathway that involves phosphorylation of the NF-kappaB subunit p65 at serine 276.	Tetradecanoylphorbol Acetate	65-68	peroxiredoxin 1	Homo sapiens	40-45
17069861-4	2006	Furthermore, phorbol myristate acetate (PMA), a PKC stimulant, but not dibutyryl cyclic AMP, a protein kinase A stimulant, decreased the levels of HSP27.	Tetradecanoylphorbol Acetate	40-43	heat shock protein family B (small) member 1	Homo sapiens	147-152
3855302-4	1985	We found that the phorbol esters, 12-O-tetradecanoyl phorbol 13-acetate and phorbol 12,13-dibutyrate 1) altered the morphology of the TT cells towards that of high-calcitonin-containing cells; 2) enhanced calcitonin secretion 7-fold; 3) increased calcitonin production at the transcriptional level by 2-fold; 4) inhibited cellular proliferation; and 5) decreased, by 80%, the levels of the c-myc gene mRNA.	Tetradecanoylphorbol Acetate	34-71	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	390-395
17112412-6	2006	We also used a series of NR2A mutants with a partial deletion of its C-terminus to identify the regions that are involved in the PMA-mediated surface expression of NR2A subunits.	Tetradecanoylphorbol Acetate	129-132	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	25-29
17112412-6	2006	We also used a series of NR2A mutants with a partial deletion of its C-terminus to identify the regions that are involved in the PMA-mediated surface expression of NR2A subunits.	Tetradecanoylphorbol Acetate	129-132	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	164-168
17947506-3	2008	Monocytes and, to a much lesser extent, granulocytes isolated from lipopolysaccharide (LPS)/phorbol 12-myristate-13-acetate (PMA)-stimulated whole blood contained active TF antigen.	Tetradecanoylphorbol Acetate	92-123	coagulation factor III, tissue factor	Homo sapiens	170-172
17947506-3	2008	Monocytes and, to a much lesser extent, granulocytes isolated from lipopolysaccharide (LPS)/phorbol 12-myristate-13-acetate (PMA)-stimulated whole blood contained active TF antigen.	Tetradecanoylphorbol Acetate	125-128	coagulation factor III, tissue factor	Homo sapiens	170-172
17947506-4	2008	However, only monocytes possessed significant TF activity and protein levels when stimulated with LPS/PMA in suspension.	Tetradecanoylphorbol Acetate	102-105	coagulation factor III, tissue factor	Homo sapiens	46-48
17947506-5	2008	Reintroduction of TF-silenced monocytes to whole blood led to a profound reduction of LPS/PMA-stimulated TF activity in both mononuclear cell (MNC) and granulocyte fractions.	Tetradecanoylphorbol Acetate	90-93	coagulation factor III, tissue factor	Homo sapiens	18-20
17112412-7	2006	RESULTS: NR2A subunits were expressed on the cell membrane after incubation with PMA (200 nmol/L, 30 min), although no functional NMDA channels were detected after PMA-induced membrane trafficking.	Tetradecanoylphorbol Acetate	81-84	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	9-13
17112412-8	2006	Immunostaining with an ER marker also revealed that NR2A subunits were exported from the ER after PMA treatment.	Tetradecanoylphorbol Acetate	98-101	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	52-56
2984222-2	1985	We have investigated the effects of the tumor promoter phorbol myristate acetate [PMA] on EGF/eTGF receptors in intact A431 cells.	Tetradecanoylphorbol Acetate	55-80	epidermal growth factor	Homo sapiens	90-93
17112412-9	2006	Furthermore, the deletion of amino acids between 1149-1347 or 1354-1464 of NR2A inhibited PMA-induced surface expression of NR2A subunits.	Tetradecanoylphorbol Acetate	90-93	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	75-79
17112412-9	2006	Furthermore, the deletion of amino acids between 1149-1347 or 1354-1464 of NR2A inhibited PMA-induced surface expression of NR2A subunits.	Tetradecanoylphorbol Acetate	90-93	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	124-128
17112412-10	2006	CONCLUSION: First, our data suggests that PMA treatment can induce the surface expression of homomeric NR2A subunits.	Tetradecanoylphorbol Acetate	42-45	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	103-107
17947506-5	2008	Reintroduction of TF-silenced monocytes to whole blood led to a profound reduction of LPS/PMA-stimulated TF activity in both mononuclear cell (MNC) and granulocyte fractions.	Tetradecanoylphorbol Acetate	90-93	coagulation factor III, tissue factor	Homo sapiens	105-107
19388361-0	2008	The modulation of aquaporin-4 by using PKC-activator (phorbol myristate acetate) and V1a receptor antagonist (SR49059) following middle cerebral artery occlusion/reperfusion in the rat.	Tetradecanoylphorbol Acetate	54-79	aquaporin 4	Rattus norvegicus	18-29
19388361-3	2008	Phorbol myristate acetate (PMA) is a potent PKC activator; purportedly involved in modulation of AQP4 activity.	Tetradecanoylphorbol Acetate	0-25	aquaporin 4	Rattus norvegicus	97-101
19388361-3	2008	Phorbol myristate acetate (PMA) is a potent PKC activator; purportedly involved in modulation of AQP4 activity.	Tetradecanoylphorbol Acetate	27-30	aquaporin 4	Rattus norvegicus	97-101
2984222-2	1985	We have investigated the effects of the tumor promoter phorbol myristate acetate [PMA] on EGF/eTGF receptors in intact A431 cells.	Tetradecanoylphorbol Acetate	82-85	epidermal growth factor	Homo sapiens	90-93
2984222-3	1985	Treatment with PMA at 37 degrees C induces a complete loss of high-affinity (Kd = 35-50 pM) binding sites for eTGF and EGF on the cell surface of A431 cells.	Tetradecanoylphorbol Acetate	15-18	epidermal growth factor	Homo sapiens	110-122
3917280-4	1985	PMA-induced EL-4 SN and SN from antigen-activated cloned T cells, neither of which were capable of inducing cytolytic activity alone, were able to synergize in the cytolytic induction of KSH.4.13.6 IFN-gamma and IL 1 failed to induce cytolytic activity even in the presence of EL-4 SN.	Tetradecanoylphorbol Acetate	0-3	interleukin 18	Rattus norvegicus	198-207
18257749-5	2008	In cells treated with NA or phorbol myristate acetate the amount of coimmunoprecipitated GRK2 and GRK3 increased ( approximately 2- to 3-fold), while treatment with ET-1 only augmented the amount of coimmunoprecipitated GRK2 ( approximately 2-fold).	Tetradecanoylphorbol Acetate	28-53	G protein-coupled receptor kinase 3	Homo sapiens	98-102
17947356-8	2008	Consistent with this idea, we also found that direct stimulation of PKC with the phorbol ester phorbol 12-myristate 13-acetate induced eEF2 dephosphorylation.	Tetradecanoylphorbol Acetate	95-126	eukaryotic translation elongation factor 2	Homo sapiens	135-139
17176442-6	2006	Upon phytohemagglutinin or phorbol myristate acetate activation, the expression level of the Na, K ATPase beta3 subunit on activated peripheral blood mononuclear cells was not altered in comparison with those of unstimulated cells.	Tetradecanoylphorbol Acetate	27-52	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	106-111
17108111-0	2006	Mutant p53 protects cells from 12-O-tetradecanoylphorbol-13-acetate-induced death by attenuating activating transcription factor 3 induction.	Tetradecanoylphorbol Acetate	31-67	activating transcription factor 3	Homo sapiens	97-130
17108111-3	2006	In this study, we explore how the status of p53 affects the immediate response gene activating transcription factor 3 (ATF3) in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-protein kinase C (PKC) pathway.	Tetradecanoylphorbol Acetate	132-168	activating transcription factor 3	Homo sapiens	119-123
17108111-3	2006	In this study, we explore how the status of p53 affects the immediate response gene activating transcription factor 3 (ATF3) in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-protein kinase C (PKC) pathway.	Tetradecanoylphorbol Acetate	170-173	activating transcription factor 3	Homo sapiens	119-123
17108111-4	2006	We show that high doses of TPA induce ATF3 in a WT p53-independent manner correlating with PKCs depletion and cell death.	Tetradecanoylphorbol Acetate	27-30	activating transcription factor 3	Homo sapiens	38-42
3881820-9	1985	IL-1 activity could not be measured directly in the supernatants owing to the synergistic effect of TPA in the assay system.	Tetradecanoylphorbol Acetate	100-103	interleukin 1 alpha	Homo sapiens	0-4
17108111-6	2006	Mutagenesis analysis of the ATF3 promoter identified the regulatory motifs cyclic AMP-responsive element binding protein/ATF and MEF2 as being responsible for the TPA-induced activation of ATF3.	Tetradecanoylphorbol Acetate	163-166	activating transcription factor 3	Homo sapiens	28-32
17108111-6	2006	Mutagenesis analysis of the ATF3 promoter identified the regulatory motifs cyclic AMP-responsive element binding protein/ATF and MEF2 as being responsible for the TPA-induced activation of ATF3.	Tetradecanoylphorbol Acetate	163-166	activating transcription factor 3	Homo sapiens	189-193
18187925-4	2008	Sensitization elevated allergen-specific IgE levels in serum, the number of CCR4-positive T helper lymphocytes in peripheral blood, and IL-4 and IL-5 releases from phorbol 12-myristate 13-acetate- and ionomycin-stimulated peripheral blood.	Tetradecanoylphorbol Acetate	164-195	interleukin-4	Macaca fascicularis	136-140
18187925-4	2008	Sensitization elevated allergen-specific IgE levels in serum, the number of CCR4-positive T helper lymphocytes in peripheral blood, and IL-4 and IL-5 releases from phorbol 12-myristate 13-acetate- and ionomycin-stimulated peripheral blood.	Tetradecanoylphorbol Acetate	164-195	interleukin-5	Macaca fascicularis	145-149
3881820-10	1985	Unequivocal removal of the phorbol was not achieved, but the data indicated that the "real" levels of IL-1 in the TPA-induced cultures were not significantly higher than those from LPS-induced cultures.	Tetradecanoylphorbol Acetate	114-117	interleukin 1 alpha	Homo sapiens	102-106
6335665-7	1984	Northern blot experiments with cloned TCGF DNA as a probe showed that TCGF mRNA was induced rapidly in cells treated with TPA and phytohemagglutinin, and this induction was augmented by interleukin 1.	Tetradecanoylphorbol Acetate	122-125	interleukin 1 alpha	Homo sapiens	186-199
18212352-2	2008	In this article, the authors investigate the regulation of the CRH gene"s promoter activity by a protein kinase C (PKC) activator, phorbol-12-myristate-13-acetate (PMA), in primary cultures of placental cells.	Tetradecanoylphorbol Acetate	131-162	corticotropin releasing hormone	Homo sapiens	63-66
18212352-2	2008	In this article, the authors investigate the regulation of the CRH gene"s promoter activity by a protein kinase C (PKC) activator, phorbol-12-myristate-13-acetate (PMA), in primary cultures of placental cells.	Tetradecanoylphorbol Acetate	164-167	corticotropin releasing hormone	Homo sapiens	63-66
17069809-3	2006	In PMN, PP also inhibits the PMA-stimulated phosphorylation of p47(phox) and its subsequent translocation.	Tetradecanoylphorbol Acetate	29-32	pleckstrin	Homo sapiens	63-66
17106266-5	2006	We now present the evidence that induction of oxidative stress in human peripheral blood leukocytes by phorbol myristate acetate (PMA) was associated with intense phosphorylation of histone H2AX and with ATM activation, seen already 60 min after exposure to PMA.	Tetradecanoylphorbol Acetate	103-128	ATM serine/threonine kinase	Homo sapiens	204-207
17106266-5	2006	We now present the evidence that induction of oxidative stress in human peripheral blood leukocytes by phorbol myristate acetate (PMA) was associated with intense phosphorylation of histone H2AX and with ATM activation, seen already 60 min after exposure to PMA.	Tetradecanoylphorbol Acetate	130-133	ATM serine/threonine kinase	Homo sapiens	204-207
6611200-6	1984	During blastic transformation, the erythrocyte rosette receptor was induced by TPA on sheep erythrocyte-rosette-negative Sezary cells from one patient.	Tetradecanoylphorbol Acetate	79-82	CD2 molecule	Homo sapiens	47-63
16721813-7	2006	Knockdown hMSH6 or hPMS2 with siRNA in DLD-1+Ch2 cells resulted in more resistant to TPA-induced cell killing, further suggesting that MMR proteins involve in TPA or ROS-induced cell killing.	Tetradecanoylphorbol Acetate	85-88	mutS homolog 6	Homo sapiens	10-15
17942404-3	2007	In the present study we present new evidence that a disintegrin and metalloproteinase-17 (ADAM17) is responsible for phorbol 12-myristate 13-acetate-induced release of TMEFF2-ECD using small interfering RNA to ablate ADAM17 expression or by inhibiting enzymatic activity.	Tetradecanoylphorbol Acetate	117-148	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	168-174
18067864-2	2007	Here, we found that overexpression of phospholipase D (PLD) isozymes decreased tumor promoter phorbol myristate acetate (PMA)-induced Egr-1 expression and transactivation in glioma cells.	Tetradecanoylphorbol Acetate	121-124	early growth response 1	Homo sapiens	134-139
18067864-6	2007	Taken together, these results suggest that elevated expression and activity of PLD attenuate PMA-induced Egr-1 expression via PI3K pathway.	Tetradecanoylphorbol Acetate	93-96	early growth response 1	Homo sapiens	105-110
16721813-7	2006	Knockdown hMSH6 or hPMS2 with siRNA in DLD-1+Ch2 cells resulted in more resistant to TPA-induced cell killing, further suggesting that MMR proteins involve in TPA or ROS-induced cell killing.	Tetradecanoylphorbol Acetate	85-88	PMS1 homolog 2, mismatch repair system component	Homo sapiens	19-24
16721813-7	2006	Knockdown hMSH6 or hPMS2 with siRNA in DLD-1+Ch2 cells resulted in more resistant to TPA-induced cell killing, further suggesting that MMR proteins involve in TPA or ROS-induced cell killing.	Tetradecanoylphorbol Acetate	159-162	mutS homolog 6	Homo sapiens	10-15
16721813-7	2006	Knockdown hMSH6 or hPMS2 with siRNA in DLD-1+Ch2 cells resulted in more resistant to TPA-induced cell killing, further suggesting that MMR proteins involve in TPA or ROS-induced cell killing.	Tetradecanoylphorbol Acetate	159-162	PMS1 homolog 2, mismatch repair system component	Homo sapiens	19-24
6611200-9	1984	Blastic transformation of CTCL cells was observed with both TPA and phytohemagglutinin, but helper T-cell antigen Leu 3a (T4) and erythrocyte rosette receptor changes occurred only with TPA.	Tetradecanoylphorbol Acetate	186-189	CD2 molecule	Homo sapiens	142-158
18199973-9	2007	PMA treatment in the subconjunctival fibroblasts elicited phosphorylation of SAPKs, including c-jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAPK).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Rattus norvegicus	94-117
6539129-2	1984	In confluent cultures of H35 cells, the addition of TPA (1.6 microM) caused the activity of ornithine decarboxylase to increase by more than 100-fold within 4 h. When exogenous ornithine (0.1-1.0 mM) was added to the culture medium with TPA, a marked dose-dependent increase in the production of putrescine was observed.	Tetradecanoylphorbol Acetate	52-55	ornithine decarboxylase 1	Rattus norvegicus	92-115
18199973-9	2007	PMA treatment in the subconjunctival fibroblasts elicited phosphorylation of SAPKs, including c-jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAPK).	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Rattus norvegicus	119-122
18199973-12	2007	The phosphorylation of c-jun and heat shock protein 27, downstream effectors of JNK and p38MAPK, respectively, was upregulated by PMA treatment.	Tetradecanoylphorbol Acetate	130-133	mitogen-activated protein kinase 8	Rattus norvegicus	80-83
17942077-7	2007	We also observed that PKCalpha, beta1, beta2, gamma, delta, epsilon, and eta translocate to the plasma membrane within 10 min of the start of TPA treatment, while the cellular localizations of PKCzeta and iota were not affected by TPA.	Tetradecanoylphorbol Acetate	142-145	hemoglobin, beta adult major chain	Mus musculus	32-37
17947801-6	2007	In addition, we have also shown that treatment of endothelial cells with phorbol 12-myristate 13-acetate resulted in the exportation of HDAC7 out of the nucleus through a protein kinase C/protein kinase D activation pathway and induced, similarly to HDAC7 silencing, an increase in PDGF-B expression, as well as a partial inhibition of endothelial cell migration.	Tetradecanoylphorbol Acetate	73-104	histone deacetylase 7	Homo sapiens	136-141
17947801-6	2007	In addition, we have also shown that treatment of endothelial cells with phorbol 12-myristate 13-acetate resulted in the exportation of HDAC7 out of the nucleus through a protein kinase C/protein kinase D activation pathway and induced, similarly to HDAC7 silencing, an increase in PDGF-B expression, as well as a partial inhibition of endothelial cell migration.	Tetradecanoylphorbol Acetate	73-104	histone deacetylase 7	Homo sapiens	250-255
17583568-4	2007	62: 2516, 2002) that these mice, referred to as keratin 14 (K14).COX2 mice, were unexpectedly very resistant to 12-O-tetradecanoylphorbol 13-acetate (TPA) tumor promotion.	Tetradecanoylphorbol Acetate	112-148	keratin 14	Mus musculus	48-58
17583568-4	2007	62: 2516, 2002) that these mice, referred to as keratin 14 (K14).COX2 mice, were unexpectedly very resistant to 12-O-tetradecanoylphorbol 13-acetate (TPA) tumor promotion.	Tetradecanoylphorbol Acetate	112-148	keratin 14	Mus musculus	60-63
17583568-4	2007	62: 2516, 2002) that these mice, referred to as keratin 14 (K14).COX2 mice, were unexpectedly very resistant to 12-O-tetradecanoylphorbol 13-acetate (TPA) tumor promotion.	Tetradecanoylphorbol Acetate	150-153	keratin 14	Mus musculus	48-58
17583568-4	2007	62: 2516, 2002) that these mice, referred to as keratin 14 (K14).COX2 mice, were unexpectedly very resistant to 12-O-tetradecanoylphorbol 13-acetate (TPA) tumor promotion.	Tetradecanoylphorbol Acetate	150-153	keratin 14	Mus musculus	60-63
17583568-8	2007	The TPA resistance phenotype correlated with a reduced ability to induce ornithine decarboxylase, interleukin-1alpha, and tumor necrosis factor-alpha and a reduced proliferation response.	Tetradecanoylphorbol Acetate	4-7	interleukin 1 alpha	Mus musculus	98-149
18171992-10	2007	Furthermore, inhibition of protein kinase C (PKC) activity blocked TPA-stimulated heparin-binding EGF production and EGFR transactivation.	Tetradecanoylphorbol Acetate	67-70	epidermal growth factor receptor	Mus musculus	117-121
18171992-12	2007	However, combination of EGFR inhibitor and PKC inhibitor completely abrogated TPA-induced activation of Akt.	Tetradecanoylphorbol Acetate	78-81	epidermal growth factor receptor	Mus musculus	24-28
17702895-5	2007	Importantly, silencing of the Rap1 guanine exchange factor CalDAG-GEFI inhibited SDF-1alpha- and phorbol 12-myristate 13-acetate (PMA)-induced adhesion to ICAM-1 while having no effect on adhesion to VCAM-1.	Tetradecanoylphorbol Acetate	97-128	RAP1A, member of RAS oncogene family	Homo sapiens	30-34
17702895-5	2007	Importantly, silencing of the Rap1 guanine exchange factor CalDAG-GEFI inhibited SDF-1alpha- and phorbol 12-myristate 13-acetate (PMA)-induced adhesion to ICAM-1 while having no effect on adhesion to VCAM-1.	Tetradecanoylphorbol Acetate	97-128	RAS guanyl releasing protein 1	Homo sapiens	59-70
17702895-5	2007	Importantly, silencing of the Rap1 guanine exchange factor CalDAG-GEFI inhibited SDF-1alpha- and phorbol 12-myristate 13-acetate (PMA)-induced adhesion to ICAM-1 while having no effect on adhesion to VCAM-1.	Tetradecanoylphorbol Acetate	130-133	RAP1A, member of RAS oncogene family	Homo sapiens	30-34
17702895-5	2007	Importantly, silencing of the Rap1 guanine exchange factor CalDAG-GEFI inhibited SDF-1alpha- and phorbol 12-myristate 13-acetate (PMA)-induced adhesion to ICAM-1 while having no effect on adhesion to VCAM-1.	Tetradecanoylphorbol Acetate	130-133	RAS guanyl releasing protein 1	Homo sapiens	59-70
17724030-8	2007	In vitro kinase assays revealed that equol greatly inhibited MEK1, but not Raf1, kinase activity, and an ex vivo kinase assay also demonstrated that equol suppressed TPA-induced MEK1 kinase activity in JB6 P+ cell lysates.	Tetradecanoylphorbol Acetate	166-169	mitogen-activated protein kinase kinase 1	Homo sapiens	178-182
17694297-6	2007	RESULTS: Thapsigargin and PMA enhanced GLUT-mediated glucose uptake, but had no effect on sodium-dependent glucose transport.	Tetradecanoylphorbol Acetate	26-29	glutaminase	Rattus norvegicus	39-43
17786281-0	2007	Src regulates phorbol 12-myristate 13-acetate-activated PKC-induced migration via Cas/Crk/Rac1 signaling pathway in glioblastoma cells.	Tetradecanoylphorbol Acetate	14-45	BCAR1 scaffold protein, Cas family member	Homo sapiens	82-85
17786281-2	2007	PMA treatment induced tyrosine phosphorylation of Crk-associated substrate (Cas) and formation of a complex with Crk, followed by Rac1 activation, a downstream effector of Cas/Crk complex.	Tetradecanoylphorbol Acetate	0-3	BCAR1 scaffold protein, Cas family member	Homo sapiens	50-74
17786281-2	2007	PMA treatment induced tyrosine phosphorylation of Crk-associated substrate (Cas) and formation of a complex with Crk, followed by Rac1 activation, a downstream effector of Cas/Crk complex.	Tetradecanoylphorbol Acetate	0-3	BCAR1 scaffold protein, Cas family member	Homo sapiens	76-79
17786281-2	2007	PMA treatment induced tyrosine phosphorylation of Crk-associated substrate (Cas) and formation of a complex with Crk, followed by Rac1 activation, a downstream effector of Cas/Crk complex.	Tetradecanoylphorbol Acetate	0-3	BCAR1 scaffold protein, Cas family member	Homo sapiens	172-175
17760827-8	2007	The phorbol ester, phorbol 12-myristate 13-acetate, which activates protein kinase C signaling, induced egr1 mRNA levels 66-fold over the control, whereas forskolin (a cAMP-protein kinase A activator) and ionomycin (a calcium activator) had no effect.	Tetradecanoylphorbol Acetate	19-50	early growth response 1	Homo sapiens	104-108
17896949-1	2007	Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA, respectively).	Tetradecanoylphorbol Acetate	125-128	serpin family E member 1	Homo sapiens	0-33
17896949-1	2007	Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA, respectively).	Tetradecanoylphorbol Acetate	125-128	serpin family E member 1	Homo sapiens	35-40
17681786-3	2007	In this study, we demonstrated that various inflammatory agents, including lipopolysaccharide, 12-o-tetradecanoylphorbol-13-acetate, hydrogen peroxide, okadaic acid and ceramide, were able to induce IL-1beta and TNF-alpha productions in human lung epithelial cells (A-549), fibroblasts (HFL1), and lymphoma cells (U-937).	Tetradecanoylphorbol Acetate	95-131	complement factor H related 1	Homo sapiens	287-291
17443671-4	2007	However, in the presence of a phorbol ester, TPA, TF-1-fms cells definitely switched their responsiveness to M-CSF from proliferation to differentiation, as evidenced by a more drastic morphological change and the appearance of cells with a higher level of phagocytic activity.	Tetradecanoylphorbol Acetate	45-48	colony stimulating factor 1	Homo sapiens	109-114
17443671-5	2007	In TF-1-fms cells expressing HIV-1 Nef protein in a conditionally active-manner, both M-CSF-mediated proliferation and M-CSF/TPA-mediated differentiation were inhibited by the activation of Nef.	Tetradecanoylphorbol Acetate	125-128	colony stimulating factor 1	Homo sapiens	119-124
17443671-7	2007	Under the proliferation-inducing conditions (TPA-free), parental or Nef-inactive cells showed modest ERK activation following M-CSF stimulation, whereas Nef-active cells showed an earlier and transient ERK activation, despite a decrease in their proliferation rate.	Tetradecanoylphorbol Acetate	45-48	colony stimulating factor 1	Homo sapiens	126-131
17673262-3	2007	12-O-tetradecanoylphorbol-13-acetate (TPA) and 1-oleoyl-2-acetylglycerol, direct activators of protein kinase C (PKC), markedly strengthened the phosphorylation of HSP27.	Tetradecanoylphorbol Acetate	0-36	heat shock protein family B (small) member 1	Homo sapiens	164-169
17673262-3	2007	12-O-tetradecanoylphorbol-13-acetate (TPA) and 1-oleoyl-2-acetylglycerol, direct activators of protein kinase C (PKC), markedly strengthened the phosphorylation of HSP27.	Tetradecanoylphorbol Acetate	38-41	heat shock protein family B (small) member 1	Homo sapiens	164-169
17673262-4	2007	Bisindorylmaleimide I, an inhibitor of PKC, suppressed the TPA-induced levels of HSP27 phosphorylation in addition to its basal levels.	Tetradecanoylphorbol Acetate	59-62	heat shock protein family B (small) member 1	Homo sapiens	81-86
17673262-6	2007	SB203580, an inhibitor of p38 MAPK, suppressed the TPA-induced HSP27 phosphorylation.	Tetradecanoylphorbol Acetate	51-54	heat shock protein family B (small) member 1	Homo sapiens	63-68
17531200-5	2007	Cabin1 (701-900) blocked both CN-mediated dephosphorylation and nuclear import of NFAT and thus inhibited IL-2 production in response to PMA/ionomycin stimulation.	Tetradecanoylphorbol Acetate	137-140	interleukin 2	Mus musculus	106-110
17510061-3	2007	Using exogenous and endogenous fluorescence, we demonstrate here that maspin can bind uPA and tPA in both single-chain and double-chain forms, with K(d) values between 300 and 600 nM.	Tetradecanoylphorbol Acetate	94-97	serpin family B member 5	Homo sapiens	70-76
17510061-5	2007	The binding site on tPA does not involve the proteinase active site, with the result that maspin can bind to S195A tPA that is already complexed to plasminogen activator inhibitor-1.	Tetradecanoylphorbol Acetate	20-23	serpin family B member 5	Homo sapiens	90-96
17510061-5	2007	The binding site on tPA does not involve the proteinase active site, with the result that maspin can bind to S195A tPA that is already complexed to plasminogen activator inhibitor-1.	Tetradecanoylphorbol Acetate	115-118	serpin family B member 5	Homo sapiens	90-96
17372274-6	2007	Pre-treatment with humulone attenuated TPA-induced phosphorylation of p65 and nuclear translocation of NF-kappaB subunit proteins.	Tetradecanoylphorbol Acetate	39-42	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	70-73
17372274-7	2007	Humulone blunted TPA-induced activation of inhibitory kappaB (IkappaB) kinase (IKK) in mouse skin, which accounts for its suppression of phosphorylation and subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	17-20	inhibitor of kappaB kinase beta	Mus musculus	79-82
17372274-12	2007	Taken together, humulone suppressed TPA-induced activation of NF-kappaB and AP-1 and subsequent expression of COX-2 by blocking upstream kinases IKK and JNK, respectively, which may account for its antitumor-promoting effects on mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	36-39	inhibitor of kappaB kinase beta	Mus musculus	145-148
17446183-5	2007	Activators of cAMP and protein kinase C like forskolin and phorbol 12-myristate 3-acetate (PMA), respectively, mimicked GnRH action.	Tetradecanoylphorbol Acetate	91-94	gonadotropin releasing hormone 1	Mus musculus	120-124
17327401-5	2007	We show here, using viable Kit- null mice (Kit(W/W)), that Kit is essential for mast-cell accumulation in phorbol-12-myristate-13-acetate (PMA)-treated, chronically inflamed skin.	Tetradecanoylphorbol Acetate	106-137	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	27-30
17327401-5	2007	We show here, using viable Kit- null mice (Kit(W/W)), that Kit is essential for mast-cell accumulation in phorbol-12-myristate-13-acetate (PMA)-treated, chronically inflamed skin.	Tetradecanoylphorbol Acetate	106-137	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	43-46
17327401-5	2007	We show here, using viable Kit- null mice (Kit(W/W)), that Kit is essential for mast-cell accumulation in phorbol-12-myristate-13-acetate (PMA)-treated, chronically inflamed skin.	Tetradecanoylphorbol Acetate	106-137	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	43-46
17327401-5	2007	We show here, using viable Kit- null mice (Kit(W/W)), that Kit is essential for mast-cell accumulation in phorbol-12-myristate-13-acetate (PMA)-treated, chronically inflamed skin.	Tetradecanoylphorbol Acetate	139-142	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	27-30
17327401-5	2007	We show here, using viable Kit- null mice (Kit(W/W)), that Kit is essential for mast-cell accumulation in phorbol-12-myristate-13-acetate (PMA)-treated, chronically inflamed skin.	Tetradecanoylphorbol Acetate	139-142	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	43-46
17327401-5	2007	We show here, using viable Kit- null mice (Kit(W/W)), that Kit is essential for mast-cell accumulation in phorbol-12-myristate-13-acetate (PMA)-treated, chronically inflamed skin.	Tetradecanoylphorbol Acetate	139-142	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	43-46
17355247-10	2007	Moreover, leptin enhanced the expression of CD69 and CD25 on CD4(+) and CD8(+) cells after stimulation with PMA-ionomycin.	Tetradecanoylphorbol Acetate	108-111	leptin	Homo sapiens	10-16
17408801-8	2007	IRS-4 down-regulation abolished IGF-I-, TPA- and IGF-I plus TPA-stimulated ERK and p70S6K activities.	Tetradecanoylphorbol Acetate	40-43	insulin receptor substrate 4	Homo sapiens	0-5
17452290-4	2007	We found that PKC activation with phorbol 12-myristate 13-acetate (PMA) produced a rapid and transient phosphorylation of CREB.	Tetradecanoylphorbol Acetate	34-65	cAMP responsive element binding protein 1	Rattus norvegicus	122-126
17452290-4	2007	We found that PKC activation with phorbol 12-myristate 13-acetate (PMA) produced a rapid and transient phosphorylation of CREB.	Tetradecanoylphorbol Acetate	67-70	cAMP responsive element binding protein 1	Rattus norvegicus	122-126
17452290-6	2007	Interestingly, the PMA-induced CREB phosphorylation was also blocked by a calcium/calmodulin-dependent protein kinase inhibitor KN93 and the two mitogen-activated protein kinase (MAPK) kinase inhibitors PD98059 and U0126, but not by a p38 MAPK inhibitor SB203580.	Tetradecanoylphorbol Acetate	19-22	cAMP responsive element binding protein 1	Rattus norvegicus	31-35
17452290-8	2007	The protein kinase A (PKA) inhibitor H89 at a dose that completely blocked the PKA activator (8-br-cAMP)-induced CREB phosphorylation partially blocked the PMA-stimulated CREB phosphorylation.	Tetradecanoylphorbol Acetate	156-159	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	4-20
17452290-8	2007	The protein kinase A (PKA) inhibitor H89 at a dose that completely blocked the PKA activator (8-br-cAMP)-induced CREB phosphorylation partially blocked the PMA-stimulated CREB phosphorylation.	Tetradecanoylphorbol Acetate	156-159	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	22-25
17452290-8	2007	The protein kinase A (PKA) inhibitor H89 at a dose that completely blocked the PKA activator (8-br-cAMP)-induced CREB phosphorylation partially blocked the PMA-stimulated CREB phosphorylation.	Tetradecanoylphorbol Acetate	156-159	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	79-82
17407192-5	2007	Nuclear levels of T-bet increased in response to PMA/ionomycin in PBMC from non-pregnant, but not pregnant women.	Tetradecanoylphorbol Acetate	49-52	T-box transcription factor 21	Homo sapiens	18-23
17227770-2	2007	Exposure of untransfected C5N keratinocytes and transfected HEK293 cells to phorbol esters (12-O-tetradecanoylphorbol-13-acetate (TPA)) increased PED/PEA-15 cellular content and enhanced its phosphorylation at serine 116 in a time-dependent fashion.	Tetradecanoylphorbol Acetate	92-128	proliferation and apoptosis adaptor protein 15	Homo sapiens	150-156
17227770-2	2007	Exposure of untransfected C5N keratinocytes and transfected HEK293 cells to phorbol esters (12-O-tetradecanoylphorbol-13-acetate (TPA)) increased PED/PEA-15 cellular content and enhanced its phosphorylation at serine 116 in a time-dependent fashion.	Tetradecanoylphorbol Acetate	130-133	proliferation and apoptosis adaptor protein 15	Homo sapiens	150-156
17164239-5	2007	Exposure of cells expressing Nox5 to phorbol 12-myristate 13-acetate (PMA) resulted in a slow and sustained increase in ROS, which was markedly different from the rapid response to ionomycin.	Tetradecanoylphorbol Acetate	37-68	NADPH oxidase 5	Homo sapiens	29-33
17164239-5	2007	Exposure of cells expressing Nox5 to phorbol 12-myristate 13-acetate (PMA) resulted in a slow and sustained increase in ROS, which was markedly different from the rapid response to ionomycin.	Tetradecanoylphorbol Acetate	70-73	NADPH oxidase 5	Homo sapiens	29-33
17164239-6	2007	PMA greatly potentiated the activity of Nox5 in response to low concentrations of ionomycin.	Tetradecanoylphorbol Acetate	0-3	NADPH oxidase 5	Homo sapiens	40-44
17164239-7	2007	The ability of PMA to increase Nox5 activity was abolished by calcium chelation and was a direct effect on enzyme activity, since PMA increased the calcium sensitivity of Nox5 in a cell-free assay.	Tetradecanoylphorbol Acetate	15-18	NADPH oxidase 5	Homo sapiens	31-35
17164239-7	2007	The ability of PMA to increase Nox5 activity was abolished by calcium chelation and was a direct effect on enzyme activity, since PMA increased the calcium sensitivity of Nox5 in a cell-free assay.	Tetradecanoylphorbol Acetate	15-18	NADPH oxidase 5	Homo sapiens	171-175
17464217-0	2007	PMA activates Stat3 in the Jak/Stat pathway and induces SOCS5 in rat brain astrocytes.	Tetradecanoylphorbol Acetate	0-3	signal transducer and activator of transcription 3	Rattus norvegicus	14-19
17101779-6	2007	Immunofluorescence microscopy and subcellular fractionation revealed that MEK1 exports PPARgamma from the nucleus, and this finding was supported by small interfering RNA knockdown of MEK1 and use of a cell-permeable interaction-blocking peptide, which prevented TPA-induced export of PPARgamma from the nucleus.	Tetradecanoylphorbol Acetate	263-266	mitogen-activated protein kinase kinase 1	Homo sapiens	74-78
17112475-8	2007	Both Cox-2a and Cox-2b expression are inducible in the kidney when fish are exposed to tetradecanoylphorbol acetate.	Tetradecanoylphorbol Acetate	87-115	prostaglandin-endoperoxide synthase 2b	Danio rerio	16-22
17712993-6	2007	Surface expression of CD63 in non-stimulated and phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, bactericidal activity of serum, and alpha-defensins level (HNP 1-3) in plasma of CGD patients were significantly higher in comparison with healthy volunteers.	Tetradecanoylphorbol Acetate	49-80	CD63 molecule	Homo sapiens	22-26
17712993-6	2007	Surface expression of CD63 in non-stimulated and phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, bactericidal activity of serum, and alpha-defensins level (HNP 1-3) in plasma of CGD patients were significantly higher in comparison with healthy volunteers.	Tetradecanoylphorbol Acetate	82-85	CD63 molecule	Homo sapiens	22-26
16935853-7	2007	Both nuclear factor of activated T cells and 12-O-tetradecanoylphorbol 13-acetate responsive elements reporter activities were induced by protein hydrolysate in cells exogenously expressing GPR93.	Tetradecanoylphorbol Acetate	45-81	lysophosphatidic acid receptor 5	Homo sapiens	190-195
17200179-0	2007	Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	186-217	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	162-171
17200179-7	2007	These results demonstrate for the first time that PMA-stimulated MUC5AC and MUC5B expressions are regulated through distinctive epidermal growth factor receptor/extracellular regulated kinase-dependent and -independent signaling pathways.	Tetradecanoylphorbol Acetate	50-53	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	65-71
16683249-10	2006	Animals treated with RFFO/TPA, DMBA/RFFO, and RFFE/TPA resulted in significant induction of cutaneous aryl hydrocarbon hydroxylase (AHH) (421-432%), ethoxyresorufin-O-deethylase (252-316%), and glutathione S-transferase (133-245%) activities.	Tetradecanoylphorbol Acetate	26-29	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	102-130
16683249-10	2006	Animals treated with RFFO/TPA, DMBA/RFFO, and RFFE/TPA resulted in significant induction of cutaneous aryl hydrocarbon hydroxylase (AHH) (421-432%), ethoxyresorufin-O-deethylase (252-316%), and glutathione S-transferase (133-245%) activities.	Tetradecanoylphorbol Acetate	26-29	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	132-135
16683249-10	2006	Animals treated with RFFO/TPA, DMBA/RFFO, and RFFE/TPA resulted in significant induction of cutaneous aryl hydrocarbon hydroxylase (AHH) (421-432%), ethoxyresorufin-O-deethylase (252-316%), and glutathione S-transferase (133-245%) activities.	Tetradecanoylphorbol Acetate	26-29	hematopoietic prostaglandin D synthase	Mus musculus	194-219
16683249-10	2006	Animals treated with RFFO/TPA, DMBA/RFFO, and RFFE/TPA resulted in significant induction of cutaneous aryl hydrocarbon hydroxylase (AHH) (421-432%), ethoxyresorufin-O-deethylase (252-316%), and glutathione S-transferase (133-245%) activities.	Tetradecanoylphorbol Acetate	51-54	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	102-130
16683249-10	2006	Animals treated with RFFO/TPA, DMBA/RFFO, and RFFE/TPA resulted in significant induction of cutaneous aryl hydrocarbon hydroxylase (AHH) (421-432%), ethoxyresorufin-O-deethylase (252-316%), and glutathione S-transferase (133-245%) activities.	Tetradecanoylphorbol Acetate	51-54	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	132-135
16683249-10	2006	Animals treated with RFFO/TPA, DMBA/RFFO, and RFFE/TPA resulted in significant induction of cutaneous aryl hydrocarbon hydroxylase (AHH) (421-432%), ethoxyresorufin-O-deethylase (252-316%), and glutathione S-transferase (133-245%) activities.	Tetradecanoylphorbol Acetate	51-54	hematopoietic prostaglandin D synthase	Mus musculus	194-219
16531003-4	2006	Anethole inhibited phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io)-induced interleukin-2 (IL-2) mRNA expression and protein secretion in EL4 mouse T-cells as determined by quantitative/competitive RT-PCR and ELISA, respectively.	Tetradecanoylphorbol Acetate	19-50	interleukin 2	Mus musculus	85-98
16531003-4	2006	Anethole inhibited phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io)-induced interleukin-2 (IL-2) mRNA expression and protein secretion in EL4 mouse T-cells as determined by quantitative/competitive RT-PCR and ELISA, respectively.	Tetradecanoylphorbol Acetate	19-50	interleukin 2	Mus musculus	100-104
16846837-0	2006	Taurine chloramine inhibits PMA-stimulated superoxide production in human neutrophils perhaps by inhibiting phosphorylation and translocation of p47(phox).	Tetradecanoylphorbol Acetate	28-31	pleckstrin	Homo sapiens	145-148
16846837-0	2006	Taurine chloramine inhibits PMA-stimulated superoxide production in human neutrophils perhaps by inhibiting phosphorylation and translocation of p47(phox).	Tetradecanoylphorbol Acetate	28-31	pleckstrin	Homo sapiens	149-153
16846837-6	2006	Translocation of p47(phox), p67(phox) and Rac was increased in response to PMA, and Tau-Cl inhibited the PMA-stimulated translocation of p47(phox) and p67(phox) to plasma membrane without affecting the translocation of Rac.	Tetradecanoylphorbol Acetate	75-78	pleckstrin	Homo sapiens	17-20
16846837-6	2006	Translocation of p47(phox), p67(phox) and Rac was increased in response to PMA, and Tau-Cl inhibited the PMA-stimulated translocation of p47(phox) and p67(phox) to plasma membrane without affecting the translocation of Rac.	Tetradecanoylphorbol Acetate	75-78	pleckstrin	Homo sapiens	21-25
16846837-6	2006	Translocation of p47(phox), p67(phox) and Rac was increased in response to PMA, and Tau-Cl inhibited the PMA-stimulated translocation of p47(phox) and p67(phox) to plasma membrane without affecting the translocation of Rac.	Tetradecanoylphorbol Acetate	75-78	pleckstrin	Homo sapiens	17-26
16846837-6	2006	Translocation of p47(phox), p67(phox) and Rac was increased in response to PMA, and Tau-Cl inhibited the PMA-stimulated translocation of p47(phox) and p67(phox) to plasma membrane without affecting the translocation of Rac.	Tetradecanoylphorbol Acetate	75-78	pleckstrin	Homo sapiens	32-36
16846837-7	2006	In addition, Tau-Cl inhibited the PMA-derived phosphorylation of p47(phox), a requirement for the translocation of cytosolic NADPH oxidase component to the plasma membrane.	Tetradecanoylphorbol Acetate	34-37	pleckstrin	Homo sapiens	65-68
16846837-7	2006	In addition, Tau-Cl inhibited the PMA-derived phosphorylation of p47(phox), a requirement for the translocation of cytosolic NADPH oxidase component to the plasma membrane.	Tetradecanoylphorbol Acetate	34-37	pleckstrin	Homo sapiens	69-73
16720572-7	2006	Activation of PKCepsilon by phorbol 12-myristate 13-acetate or H(2)O(2) resulted in mitoK(ATP)-independent inhibition of MPT opening, whereas activation of PKCepsilon by PKG or the specific PKCepsilon agonist psiepsilon receptor for activated C kinase caused mitoK(ATP)-dependent inhibition of MPT opening.	Tetradecanoylphorbol Acetate	28-59	protein kinase C epsilon	Homo sapiens	14-24
16704976-1	2006	Voltage-gated calcium channels (Ca(v)) 2.2 currents are potentiated by phorbol-12-myristate, 13-acetate (PMA), whereas Ca(v) 2.3 currents are increased by both PMA and acetyl-beta-methylcholine (MCh).	Tetradecanoylphorbol Acetate	105-108	calcium channel, voltage-dependent, N type, alpha 1B subunit S homeolog	Xenopus laevis	32-42
16631161-5	2006	Our results indicate that, prior to inducing a state of competency for plasminogen-dependent scattering, PMA triggers an ordered succession of events where upregulation of the activity of u-PA precedes proteolysis of u-PAR and active degradation of the extracellular matrix (ECM).	Tetradecanoylphorbol Acetate	105-108	plasminogen activator, urokinase receptor	Homo sapiens	217-222
16491121-3	2006	Interaction between Smad6 and PrKX was also confirmed in human myeloid HL-60 cells following their phorbol 12-myristate 13-acetate (PMA)-induced differentiation into macrophages.	Tetradecanoylphorbol Acetate	99-130	SMAD family member 6	Homo sapiens	20-25
16491121-3	2006	Interaction between Smad6 and PrKX was also confirmed in human myeloid HL-60 cells following their phorbol 12-myristate 13-acetate (PMA)-induced differentiation into macrophages.	Tetradecanoylphorbol Acetate	132-135	SMAD family member 6	Homo sapiens	20-25
16773182-7	2006	Inhibitors of mitogen-activated protein/extracellular signal regulated kinase (MEK), such as ERK inhibitor PD98059 and JNK inhibitors dicumarol and SP60015, but not p38 inhibitor SB203580, inhibited PMA-induced MUC5AC reporter activity.	Tetradecanoylphorbol Acetate	199-202	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	211-217
16331690-12	2006	Importantly, the PMA inhibition on OAG-induced [Ca2+]i rise was significantly reduced by PKG inhibitor KT5823 (1 microM) or DT-3 (500 nM), suggesting an important role of PKG in the PMA-induced inhibition of TRPC channels in native endothelial cells.	Tetradecanoylphorbol Acetate	17-20	protein kinase cGMP-dependent 1	Homo sapiens	89-92
16331690-12	2006	Importantly, the PMA inhibition on OAG-induced [Ca2+]i rise was significantly reduced by PKG inhibitor KT5823 (1 microM) or DT-3 (500 nM), suggesting an important role of PKG in the PMA-induced inhibition of TRPC channels in native endothelial cells.	Tetradecanoylphorbol Acetate	17-20	protein kinase cGMP-dependent 1	Homo sapiens	171-174
16603514-7	2006	Inhibiting MEK/ERK signalling by using MEK-specific inhibitors decreased expression of the TPA-induced KSHV lytic-cycle gene ORF8.	Tetradecanoylphorbol Acetate	91-94	ORF8	Human gammaherpesvirus 8	125-129
16205782-11	2006	Additionally, we found that clozapine decreased protein kinase C (PKC) level and that its action on CRH activity was attenuated by PKC activator (TPA, 0.1 microM).	Tetradecanoylphorbol Acetate	146-149	corticotropin releasing hormone	Homo sapiens	100-103
16244358-13	2006	Interference of TPA with BPDE-induced NFkappaB activation implicates abrogation of p53 function which has been discussed.	Tetradecanoylphorbol Acetate	16-19	transformation related protein 53, pseudogene	Mus musculus	83-86
16455999-3	2006	PMA treatment also rapidly attenuated sustained Akt activation mediated by a carboxy truncated G-CSF receptor, expressed in patients with acute myeloid leukemia evolving from severe congenital neutropenia.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 3 receptor	Homo sapiens	95-109
16455999-5	2006	Ro31-8820, a PKCepsilon inhibitor, also abrogated PMA-mediated inhibition of Akt activation, whereas rottlerin and Go6976, inhibitors of PKCdelta and PKCalphabetaI, respectively, exhibited no significant effects.	Tetradecanoylphorbol Acetate	50-53	protein kinase C epsilon	Homo sapiens	13-23
16210344-6	2006	In primary granulosa cell cultures, cGK II mRNA was induced by phorbol 12-myristate 13-acetate enhanced by adenoviral expression of PR-A and blocked by RU486 and trilostane.	Tetradecanoylphorbol Acetate	63-94	S100 calcium binding protein A6 (calcyclin)	Mus musculus	132-136
16424000-7	2006	The proapoptotic activity of PKCdelta coupled with its ability to suppress TPA-induced expression of proinflammatory cytokines, COX-2 expression, and the phosphorylation of Akt and p38 may play roles in the suppression of TPA-promoted development of SCC.	Tetradecanoylphorbol Acetate	75-78	serpin family B member 3	Homo sapiens	250-253
16671492-0	2006	Modulation of AQP4 expression by the protein kinase C activator, phorbol myristate acetate, decreases ischemia-induced brain edema.	Tetradecanoylphorbol Acetate	65-90	aquaporin 4	Rattus norvegicus	14-18
16671492-1	2006	The protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), is known to interact with aquaporin-4 (AQP4), a water-selective transporting protein abundant in astrocytes and ependymal cells, that has been found to decrease osmotically-induced swelling.	Tetradecanoylphorbol Acetate	32-63	aquaporin 4	Rattus norvegicus	97-108
16671492-1	2006	The protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), is known to interact with aquaporin-4 (AQP4), a water-selective transporting protein abundant in astrocytes and ependymal cells, that has been found to decrease osmotically-induced swelling.	Tetradecanoylphorbol Acetate	32-63	aquaporin 4	Rattus norvegicus	110-114
16671492-1	2006	The protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), is known to interact with aquaporin-4 (AQP4), a water-selective transporting protein abundant in astrocytes and ependymal cells, that has been found to decrease osmotically-induced swelling.	Tetradecanoylphorbol Acetate	65-68	aquaporin 4	Rattus norvegicus	97-108
16671492-1	2006	The protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), is known to interact with aquaporin-4 (AQP4), a water-selective transporting protein abundant in astrocytes and ependymal cells, that has been found to decrease osmotically-induced swelling.	Tetradecanoylphorbol Acetate	65-68	aquaporin 4	Rattus norvegicus	110-114
16557002-4	2006	Treatment of Vero cells overexpressing human HB-EGF with 12-O-tetradecanoylphorbol-13-acetate (TPA) caused ectodomain shedding of HB-EGF and generated two carboxyl (C)-terminal fragments with distinct electrophoretic mobilities.	Tetradecanoylphorbol Acetate	57-93	heparin binding EGF like growth factor	Homo sapiens	45-51
16557002-4	2006	Treatment of Vero cells overexpressing human HB-EGF with 12-O-tetradecanoylphorbol-13-acetate (TPA) caused ectodomain shedding of HB-EGF and generated two carboxyl (C)-terminal fragments with distinct electrophoretic mobilities.	Tetradecanoylphorbol Acetate	57-93	heparin binding EGF like growth factor	Homo sapiens	130-136
16557002-4	2006	Treatment of Vero cells overexpressing human HB-EGF with 12-O-tetradecanoylphorbol-13-acetate (TPA) caused ectodomain shedding of HB-EGF and generated two carboxyl (C)-terminal fragments with distinct electrophoretic mobilities.	Tetradecanoylphorbol Acetate	95-98	heparin binding EGF like growth factor	Homo sapiens	45-51
16557002-4	2006	Treatment of Vero cells overexpressing human HB-EGF with 12-O-tetradecanoylphorbol-13-acetate (TPA) caused ectodomain shedding of HB-EGF and generated two carboxyl (C)-terminal fragments with distinct electrophoretic mobilities.	Tetradecanoylphorbol Acetate	95-98	heparin binding EGF like growth factor	Homo sapiens	130-136
16557002-5	2006	Mutation analysis showed that Ser207 in the cytoplasmic domain of HB-EGF is phosphorylated upon TPA stimulation, generating two C-terminal fragments with distinct phosphorylation states.	Tetradecanoylphorbol Acetate	96-99	heparin binding EGF like growth factor	Homo sapiens	66-72
16183168-6	2005	Carbachol and PMA had no effect in the transcriptional regulation of Bim, whereas the reduction of Bim by both carbachol and PMA was reversed by the proteosome inhibitors, suggesting that carbachol and PMA facilitated the proteosome-dependent Bim degradation.	Tetradecanoylphorbol Acetate	125-128	BCL2 like 11	Homo sapiens	99-102
16183168-6	2005	Carbachol and PMA had no effect in the transcriptional regulation of Bim, whereas the reduction of Bim by both carbachol and PMA was reversed by the proteosome inhibitors, suggesting that carbachol and PMA facilitated the proteosome-dependent Bim degradation.	Tetradecanoylphorbol Acetate	125-128	BCL2 like 11	Homo sapiens	99-102
16183168-6	2005	Carbachol and PMA had no effect in the transcriptional regulation of Bim, whereas the reduction of Bim by both carbachol and PMA was reversed by the proteosome inhibitors, suggesting that carbachol and PMA facilitated the proteosome-dependent Bim degradation.	Tetradecanoylphorbol Acetate	125-128	BCL2 like 11	Homo sapiens	99-102
16183168-6	2005	Carbachol and PMA had no effect in the transcriptional regulation of Bim, whereas the reduction of Bim by both carbachol and PMA was reversed by the proteosome inhibitors, suggesting that carbachol and PMA facilitated the proteosome-dependent Bim degradation.	Tetradecanoylphorbol Acetate	125-128	BCL2 like 11	Homo sapiens	99-102
16305739-7	2005	Moreover, NCoA3 gene expression was also upregulated after treatment of U1 and ACH-2 cells with phorbol myristyl acetate (PMA) but not trichostatin A (TSA) and after treatment with NaB of two others HIV-1 latently infected cell lines (OM10.1 and J1.1).	Tetradecanoylphorbol Acetate	122-125	nuclear receptor coactivator 3	Homo sapiens	10-15
16305739-8	2005	IRF8 gene is only expressed in U1 cells and was also downregulated after treatment with PMA or TSA.	Tetradecanoylphorbol Acetate	88-91	interferon regulatory factor 8	Homo sapiens	0-4
16272292-6	2005	In contrast, PMA induces cyclin T1 protein up-regulation by stabilizing cyclin T1 protein, apparently independently of the proteasome and without accumulation of cyclin T1 mRNA.	Tetradecanoylphorbol Acetate	13-16	proliferating cell nuclear antigen	Homo sapiens	25-31
16272292-6	2005	In contrast, PMA induces cyclin T1 protein up-regulation by stabilizing cyclin T1 protein, apparently independently of the proteasome and without accumulation of cyclin T1 mRNA.	Tetradecanoylphorbol Acetate	13-16	proliferating cell nuclear antigen	Homo sapiens	72-78
16000638-4	2005	Treatment of confluent T84 intestinal epithelial cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (PMA) reduced the amount of NKCC1 accessible to basolateral surface biotinylation.	Tetradecanoylphorbol Acetate	116-119	solute carrier family 12 member 2	Homo sapiens	143-148
16000638-6	2005	PMA-induced internalization of NKCC1 is dependent on the epsilon-isoform of PKC as determined on the basis of sensitivity to a panel of PKC inhibitors.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 12 member 2	Homo sapiens	31-36
15994198-4	2005	Several of these effectors act through membrane receptors to trigger the protein kinase C pathway, and 12-O-tetradecanoyl phorbol-13-acetate (TPA), a modulator of this pathway, has been shown to suppress GnRH gene expression through the promoter.	Tetradecanoylphorbol Acetate	103-140	gonadotropin releasing hormone 1	Mus musculus	204-208
15994198-4	2005	Several of these effectors act through membrane receptors to trigger the protein kinase C pathway, and 12-O-tetradecanoyl phorbol-13-acetate (TPA), a modulator of this pathway, has been shown to suppress GnRH gene expression through the promoter.	Tetradecanoylphorbol Acetate	142-145	gonadotropin releasing hormone 1	Mus musculus	204-208
15994198-5	2005	We find that TPA suppresses expression through the GnRH enhancer as well as the promoter.	Tetradecanoylphorbol Acetate	13-16	gonadotropin releasing hormone 1	Mus musculus	51-55
15994198-9	2005	It is known that cooperative interaction among multiple factors is necessary for GnRH gene expression; thus, one mechanism by which TPA suppresses GnRH gene expression is to disengage some of these factors from their cis-regulatory elements.	Tetradecanoylphorbol Acetate	132-135	gonadotropin releasing hormone 1	Mus musculus	81-85
15994198-9	2005	It is known that cooperative interaction among multiple factors is necessary for GnRH gene expression; thus, one mechanism by which TPA suppresses GnRH gene expression is to disengage some of these factors from their cis-regulatory elements.	Tetradecanoylphorbol Acetate	132-135	gonadotropin releasing hormone 1	Mus musculus	147-151
16230392-8	2005	The inflammatory response to TPA was reduced in EP2 knockout mice, based on a reduced number of macrophages in the dermis and a reduced level of interleukin-1alpha mRNA expression, compared with WT mice.	Tetradecanoylphorbol Acetate	29-32	interleukin 1 alpha	Mus musculus	145-163
16175052-5	2005	alpha-Santalol treatment (1.25% and 2.5%) resulted in a significant decrease in the TPA-induced ODC activity and incorporation of [3H]thymidine in DNA in the epidermis of CD-1 mice.	Tetradecanoylphorbol Acetate	84-87	CD1 antigen complex	Mus musculus	171-175
16272134-9	2005	PI3 kinase inhibitor was found to reduce the PMA-induced mRNA expression and promoter activity in parallel with PU.1/AP-1 complex formation on EMSA.	Tetradecanoylphorbol Acetate	45-48	Spi-1 proto-oncogene	Homo sapiens	112-116
16111532-4	2005	TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64.	Tetradecanoylphorbol Acetate	0-3	CD38 molecule	Homo sapiens	95-99
16111532-4	2005	TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64.	Tetradecanoylphorbol Acetate	0-3	CEA cell adhesion molecule 6	Homo sapiens	112-117
16111532-4	2005	TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64.	Tetradecanoylphorbol Acetate	0-3	Fas cell surface death receptor	Homo sapiens	150-154
16111532-4	2005	TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64.	Tetradecanoylphorbol Acetate	0-3	Fc gamma receptor Ia	Homo sapiens	165-169
16254825-5	2005	FMLP-induced tyrosyl phosphorylation or PMA-induced serine/threonine phosphorylation and the translocation of the cytosolic proteins p47(phox) and p67(phox) to the cell membrane were suppressed in parallel to the suppression of the stimulus-induced superoxide generation.	Tetradecanoylphorbol Acetate	40-43	pleckstrin	Homo sapiens	133-142
16254825-5	2005	FMLP-induced tyrosyl phosphorylation or PMA-induced serine/threonine phosphorylation and the translocation of the cytosolic proteins p47(phox) and p67(phox) to the cell membrane were suppressed in parallel to the suppression of the stimulus-induced superoxide generation.	Tetradecanoylphorbol Acetate	40-43	pleckstrin	Homo sapiens	137-141
16156895-6	2005	However, if NOX was activated (by PMA or BzATP) in the presence of iNOS (induced by LPS and interferon-gamma) then substantial delayed neuronal death occurred over 48 hours, which was prevented by inhibitors of iNOS (1400W), NOX (apocynin) or a peroxynitrite decomposer (FeTPPS).	Tetradecanoylphorbol Acetate	34-37	interferon gamma	Rattus norvegicus	92-108
16123409-9	2005	Treatment of the corneal epithelial cells with 12-O-tetradecanoylphorbol-13-acetate increased hINV gene expression and this response is associated with increased nuclear factor binding of Sp1 and Sp3 to the Sp DNA response element.	Tetradecanoylphorbol Acetate	47-83	leishmanolysin like peptidase	Homo sapiens	94-98
16135804-5	2005	Interestingly, PMA-induced accumulation of cytoplasmic HuR occurs in parallel with an increase in the binding of HuR to SLC11A1 ARE and with an increase in the SLC11A1 mRNA level.	Tetradecanoylphorbol Acetate	15-18	ELAV like RNA binding protein 1	Homo sapiens	113-116
16075364-11	2005	Pretreatment with 1 microM PMA, which depletes PKC, had no effect on PTH- and FSK-induced RAMP3 mRNA levels but blocked PMA-induced RAMP3 mRNA levels.	Tetradecanoylphorbol Acetate	27-30	receptor (calcitonin) activity modifying protein 3	Mus musculus	132-137
15907837-4	2005	MMP production could be restored by PMA treatment, without affecting siRNA-mediated WAVE3 knockdown.	Tetradecanoylphorbol Acetate	36-39	matrix metallopeptidase 1	Homo sapiens	0-3
17257442-5	2007	METHODS: We have studied plasminogen binding to MCF-7 in which urokinase plasminogen activator receptor (uPAR) levels were upregulated by PMA (12-O-tetradecanoylphorbol-13-acetate) stimulation, allowing flexible and transient modulation of cell-surface uPA.	Tetradecanoylphorbol Acetate	138-141	plasminogen activator, urokinase receptor	Homo sapiens	63-103
17257442-5	2007	METHODS: We have studied plasminogen binding to MCF-7 in which urokinase plasminogen activator receptor (uPAR) levels were upregulated by PMA (12-O-tetradecanoylphorbol-13-acetate) stimulation, allowing flexible and transient modulation of cell-surface uPA.	Tetradecanoylphorbol Acetate	138-141	plasminogen activator, urokinase receptor	Homo sapiens	105-109
17257442-5	2007	METHODS: We have studied plasminogen binding to MCF-7 in which urokinase plasminogen activator receptor (uPAR) levels were upregulated by PMA (12-O-tetradecanoylphorbol-13-acetate) stimulation, allowing flexible and transient modulation of cell-surface uPA.	Tetradecanoylphorbol Acetate	143-179	plasminogen activator, urokinase receptor	Homo sapiens	63-103
17257442-5	2007	METHODS: We have studied plasminogen binding to MCF-7 in which urokinase plasminogen activator receptor (uPAR) levels were upregulated by PMA (12-O-tetradecanoylphorbol-13-acetate) stimulation, allowing flexible and transient modulation of cell-surface uPA.	Tetradecanoylphorbol Acetate	143-179	plasminogen activator, urokinase receptor	Homo sapiens	105-109
17005918-6	2007	NCX 6550 also significantly reduced phorbol 12-myristate 13-acetate-induced ROS production that was enhanced in isolated ApoE-/- splenocytes.	Tetradecanoylphorbol Acetate	36-67	T cell leukemia, homeobox 2	Mus musculus	0-3
17106253-9	2006	Dot blot indicated that Bicyclol inhibited mRNA expressions of H-ras, c-myc and PKCalpha genes by TPA-stimulation.	Tetradecanoylphorbol Acetate	98-101	HRas proto-oncogene, GTPase	Rattus norvegicus	63-68
16973724-9	2006	PKD phosphorylation was also dose-dependently increased by the PKC activator phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	77-108	protein kinase C epsilon	Homo sapiens	63-66
16721813-3	2006	Here DNA mismatch repair (MMR)-proficient human colon cancer cells (DLD-1+Ch2; hMSH6+) treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) undergo rapid cell death, which is significantly abolished by staurosporine (PKC inhibitor) or antioxidant, compared with the paired MMR-deficient (DLD-1; hMSH6-) cells.	Tetradecanoylphorbol Acetate	100-136	mutS homolog 6	Homo sapiens	79-84
16721813-3	2006	Here DNA mismatch repair (MMR)-proficient human colon cancer cells (DLD-1+Ch2; hMSH6+) treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) undergo rapid cell death, which is significantly abolished by staurosporine (PKC inhibitor) or antioxidant, compared with the paired MMR-deficient (DLD-1; hMSH6-) cells.	Tetradecanoylphorbol Acetate	100-136	mutS homolog 6	Homo sapiens	298-303
16721813-5	2006	Strikingly, DLD-1+Ch2 cells selected for resistance to TPA are found to lose the expression of hMSH6.	Tetradecanoylphorbol Acetate	55-58	mutS homolog 6	Homo sapiens	95-100
16721813-6	2006	Treatment of TPA-resistant DLD-1+Ch2 cells with 5-aza-2"-deoxycytidine, not only restores hMSH6 expression but also resensitizes TPA-resistant cells to TPA, suggesting that expression of hMSH6 is transcriptionally silenced by cytosine methylation confirmed directly by bisulfite sequencing.	Tetradecanoylphorbol Acetate	13-16	mutS homolog 6	Homo sapiens	90-95
16721813-6	2006	Treatment of TPA-resistant DLD-1+Ch2 cells with 5-aza-2"-deoxycytidine, not only restores hMSH6 expression but also resensitizes TPA-resistant cells to TPA, suggesting that expression of hMSH6 is transcriptionally silenced by cytosine methylation confirmed directly by bisulfite sequencing.	Tetradecanoylphorbol Acetate	13-16	mutS homolog 6	Homo sapiens	187-192
6539129-2	1984	In confluent cultures of H35 cells, the addition of TPA (1.6 microM) caused the activity of ornithine decarboxylase to increase by more than 100-fold within 4 h. When exogenous ornithine (0.1-1.0 mM) was added to the culture medium with TPA, a marked dose-dependent increase in the production of putrescine was observed.	Tetradecanoylphorbol Acetate	237-240	ornithine decarboxylase 1	Rattus norvegicus	92-115
16890208-7	2006	RLIP76-/- MEFs were resistant to PKCalpha-depletion mediated growth inhibition, as well as to the PKCalpha-dependent mitogen, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	126-157	ralA binding protein 1	Homo sapiens	0-6
16890208-7	2006	RLIP76-/- MEFs were resistant to PKCalpha-depletion mediated growth inhibition, as well as to the PKCalpha-dependent mitogen, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	159-162	ralA binding protein 1	Homo sapiens	0-6
6425405-1	1984	To obtain an anti-interleukin 2 (IL 2) receptor antibody, we immunized rats with phorbol myristate acetate-pulsed mouse T lymphoblasts.	Tetradecanoylphorbol Acetate	81-106	interleukin 2	Mus musculus	33-37
16936117-14	2006	Phosphorylated MLC in response to histamine or PMA was found in a punctate form in close proximity to ZO-1, a marker of the tight junctional complex.	Tetradecanoylphorbol Acetate	47-50	tight junction protein 1	Bos taurus	102-106
15937142-5	2005	Furthermore, phorbol 12-myristate 13-acetate/ionomycin treatment induced surface expression of Fas-L and TRAIL.	Tetradecanoylphorbol Acetate	13-44	Fas ligand	Homo sapiens	95-100
15949478-5	2005	METHODS AND RESULTS: Downregulation of PKC by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis, the activation of MAPK, and the expression of c-myc, demonstrating the involvement of PMA-sensitive PKC isoforms in growth factor-induced proliferation and the MAPK pathway.	Tetradecanoylphorbol Acetate	46-77	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	168-173
15949478-5	2005	METHODS AND RESULTS: Downregulation of PKC by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis, the activation of MAPK, and the expression of c-myc, demonstrating the involvement of PMA-sensitive PKC isoforms in growth factor-induced proliferation and the MAPK pathway.	Tetradecanoylphorbol Acetate	79-82	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	168-173
6229371-2	1984	We have studied 16 untreated SLE patients to determine the production of IL-1 by their monocytes under the stimulus of E. Coli lipopolysaccharide (LPS) or phorbol myristate acetate (PMA) and measured by the capacity of their supernatants to augment normal autologous mixed lymphocyte cultures (AMLR) or to replace accessory cells in Con A-induced proliferation of T lymphocytes.	Tetradecanoylphorbol Acetate	155-180	interleukin 1 alpha	Homo sapiens	73-77
15798003-8	2005	In contrast, when HUVECs were treated with phorbol 12-myristate 13-acetate, a PKC activator, we observed a significant increase in Snn gene expression.	Tetradecanoylphorbol Acetate	43-74	stannin	Homo sapiens	131-134
16741954-7	2006	All of these effects of GnRH were mimicked by phorbol 12 myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	46-77	gonadotropin releasing hormone 1	Mus musculus	24-28
16741954-7	2006	All of these effects of GnRH were mimicked by phorbol 12 myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	79-82	gonadotropin releasing hormone 1	Mus musculus	24-28
16928126-2	2006	The modeling two-photon absorption spectra show that these charge-transfer complexes have large two-photon absorption (TPA) cross sections and the [NEt4I.CBr4] has the largest TPA cross section delta with the value of 5.0 x 10(-45) cm4 s photon(-1).	Tetradecanoylphorbol Acetate	119-122	carbonyl reductase 4	Homo sapiens	154-158
15889157-6	2005	Further, we provide evidence that cotransfection with Ets-1 and constitutively active Mek-1 in HTLV-1-negative transformed T cells with stimulation by PMA/ionomycin not only resulted in a robust induction of PTHrP P3 but also formed a complex with ETS-1/P3 EBS similar to that in ATLL cells.	Tetradecanoylphorbol Acetate	151-154	ETS proto-oncogene 1, transcription factor	Homo sapiens	54-59
6724225-2	1984	A single instillation of TPA, at a dose as low as 16 nmol, led to a significant (about 10-fold) increase in colonic ODC activity.	Tetradecanoylphorbol Acetate	25-28	ornithine decarboxylase 1	Rattus norvegicus	116-119
15889157-6	2005	Further, we provide evidence that cotransfection with Ets-1 and constitutively active Mek-1 in HTLV-1-negative transformed T cells with stimulation by PMA/ionomycin not only resulted in a robust induction of PTHrP P3 but also formed a complex with ETS-1/P3 EBS similar to that in ATLL cells.	Tetradecanoylphorbol Acetate	151-154	ETS proto-oncogene 1, transcription factor	Homo sapiens	248-253
15878157-9	2005	TPA-induced activation of ERK and PKCdelta was dependent on the expression of EGFR although the intrinsic kinase activity of EGFR was not required.	Tetradecanoylphorbol Acetate	0-3	EPH receptor B2	Homo sapiens	26-29
16928126-2	2006	The modeling two-photon absorption spectra show that these charge-transfer complexes have large two-photon absorption (TPA) cross sections and the [NEt4I.CBr4] has the largest TPA cross section delta with the value of 5.0 x 10(-45) cm4 s photon(-1).	Tetradecanoylphorbol Acetate	176-179	carbonyl reductase 4	Homo sapiens	154-158
16928126-3	2006	The maximum values of delta increase with increasing separations between the donor/acceptor in the order Cl...Br &lt; Br...Br &lt; I...Br for [NEt4h.CBr4] complexes; however, the TPA cross sections delta vary slightly as the size of the alkyl group increases from methyl to propyl for the bromide as a donor, and the maximum wavelength of the TPA peak lambdamax indicates a bathochromic shift.	Tetradecanoylphorbol Acetate	179-182	carbonyl reductase 4	Homo sapiens	149-153
16928126-3	2006	The maximum values of delta increase with increasing separations between the donor/acceptor in the order Cl...Br &lt; Br...Br &lt; I...Br for [NEt4h.CBr4] complexes; however, the TPA cross sections delta vary slightly as the size of the alkyl group increases from methyl to propyl for the bromide as a donor, and the maximum wavelength of the TPA peak lambdamax indicates a bathochromic shift.	Tetradecanoylphorbol Acetate	343-346	carbonyl reductase 4	Homo sapiens	149-153
15878157-11	2005	Ethanol selectively inhibited TPA-induced phosphorylation of ERK and PKCdelta, and modestly suppressed TPA-stimulated AP-1 activation in B82L and B82M721 cells.	Tetradecanoylphorbol Acetate	30-33	EPH receptor B2	Homo sapiens	61-64
6232432-6	1984	Immunoprecipitation, after ectolabeling of the cells with the C17 antibody and SDS-polyacrylamide gel electrophoresis, proved that TPA-induced K562 expressed both GP IIIa and GP IIb.	Tetradecanoylphorbol Acetate	131-134	cytokine like 1	Homo sapiens	62-65
15689183-2	2005	In the present study, we found that PMA activates cPLA2 by a Rac-p38 kinase-dependent pathway.	Tetradecanoylphorbol Acetate	36-39	phospholipase A2 group IVA	Rattus norvegicus	50-55
6193876-0	1983	12-O-tetradecanoylphorbol-13-acetate actions on macromolecular synthesis, ornithine decarboxylase, and cellular differentiation of the rat embryonic visceral yolk sac in culture.	Tetradecanoylphorbol Acetate	0-36	ornithine decarboxylase 1	Rattus norvegicus	74-97
15689183-4	2005	In another experiment to understand the signalling mechanism by which the Rac-p38 kinase cascade mediates cPLA2 activation in response to PMA, we observed that PMA-induced cPLA2 translocation to the perinuclear region is completely inhibited by the expression of Rac1N17 or treatment with SB203580 (inhibitor of p38 kinase), suggesting that Rac-p38 kinase cascade acts in this instance by mediating the translocation of cPLA2.	Tetradecanoylphorbol Acetate	138-141	phospholipase A2 group IVA	Rattus norvegicus	106-111
15689183-4	2005	In another experiment to understand the signalling mechanism by which the Rac-p38 kinase cascade mediates cPLA2 activation in response to PMA, we observed that PMA-induced cPLA2 translocation to the perinuclear region is completely inhibited by the expression of Rac1N17 or treatment with SB203580 (inhibitor of p38 kinase), suggesting that Rac-p38 kinase cascade acts in this instance by mediating the translocation of cPLA2.	Tetradecanoylphorbol Acetate	138-141	phospholipase A2 group IVA	Rattus norvegicus	172-177
15689183-4	2005	In another experiment to understand the signalling mechanism by which the Rac-p38 kinase cascade mediates cPLA2 activation in response to PMA, we observed that PMA-induced cPLA2 translocation to the perinuclear region is completely inhibited by the expression of Rac1N17 or treatment with SB203580 (inhibitor of p38 kinase), suggesting that Rac-p38 kinase cascade acts in this instance by mediating the translocation of cPLA2.	Tetradecanoylphorbol Acetate	138-141	phospholipase A2 group IVA	Rattus norvegicus	172-177
16574993-9	2006	During the apical membrane ISC-cAMP recovery after prolonged high-dose PMA exposure, an almost-complete depletion of cellular PKC-beta1 and a significant reduction in PKC-epsilon mass occurred.	Tetradecanoylphorbol Acetate	71-74	protein kinase C epsilon	Homo sapiens	167-178
16761109-1	2006	The antiapoptotic BCL2 family member MCL1 is rapidly upregulated upon exposure of ML-1 myeloid leukemia cells to either differentiation-inducing phorbol 12"-myristate 13"-acetate (PMA) or chemotherapeutic microtubule disrupting agents (MTDAs).	Tetradecanoylphorbol Acetate	145-178	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	37-41
15941390-7	2005	Phorbol myristate acetate and/or forskolin increased the amount of beta-galactosidase positive cells up to fivefold.	Tetradecanoylphorbol Acetate	0-25	galactosidase, beta 1	Rattus norvegicus	67-85
16761109-1	2006	The antiapoptotic BCL2 family member MCL1 is rapidly upregulated upon exposure of ML-1 myeloid leukemia cells to either differentiation-inducing phorbol 12"-myristate 13"-acetate (PMA) or chemotherapeutic microtubule disrupting agents (MTDAs).	Tetradecanoylphorbol Acetate	180-183	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	37-41
6193876-4	1983	VYS ornithine decarboxylase levels were not induced but rather were initially depressed by TPA treatment.	Tetradecanoylphorbol Acetate	91-94	ornithine decarboxylase 1	Rattus norvegicus	4-27
6411958-3	1983	Costimulation with 500 ng 12-O-tetradecanoylphorbol 13-acetate (TPA)/ml and 5 micrograms concanavalin A (Con A)/ml induced optimal levels of IL-2.	Tetradecanoylphorbol Acetate	26-62	interleukin 2	Mus musculus	141-145
16872362-5	2006	Using synchronized HeLa cells, we show that activation of the extracellular signal-regulated kinase pathway with phorbol 12-myristate 13-acetate or epidermal growth factor during G(2) phase causes a rapid cell cycle arrest in G(2) as measured by flow cytometry, mitotic indices and cyclin B1 expression.	Tetradecanoylphorbol Acetate	113-144	cyclin B1	Homo sapiens	282-291
16888195-4	2006	Despite its positive coupling to cAMP pathway, GnRH counteracted PACAP induction of cAMP and this effect was mimicked by the PKC activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	139-170	gonadotropin releasing hormone 1	Mus musculus	47-51
15927073-10	2005	To identify the protease(s) responsible, U937 cells were treated with phorbol 12-myristate 13-acetate (PMA), an agent that induces cellular differentiation and results in decreased expression of acid-independent serine proteases, including NE and cathepsin (Cat) G.	Tetradecanoylphorbol Acetate	103-106	cathepsin G	Homo sapiens	247-264
15878350-7	2005	In HEK-293 cells transfected with rat EBP50 cDNA, a treatment with 12 myristate 13-acetate (PMA) induced a translocation of PKCalpha and beta isoforms to the membrane and increased 32P incorporation into EBP50.	Tetradecanoylphorbol Acetate	92-95	SLC9A3 regulator 1	Rattus norvegicus	38-43
15878350-7	2005	In HEK-293 cells transfected with rat EBP50 cDNA, a treatment with 12 myristate 13-acetate (PMA) induced a translocation of PKCalpha and beta isoforms to the membrane and increased 32P incorporation into EBP50.	Tetradecanoylphorbol Acetate	92-95	SLC9A3 regulator 1	Rattus norvegicus	204-209
16888195-4	2006	Despite its positive coupling to cAMP pathway, GnRH counteracted PACAP induction of cAMP and this effect was mimicked by the PKC activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	172-175	gonadotropin releasing hormone 1	Mus musculus	47-51
6411958-3	1983	Costimulation with 500 ng 12-O-tetradecanoylphorbol 13-acetate (TPA)/ml and 5 micrograms concanavalin A (Con A)/ml induced optimal levels of IL-2.	Tetradecanoylphorbol Acetate	64-67	interleukin 2	Mus musculus	141-145
16773182-4	2006	Phorbol 12-myrisate 13-acetate (PMA) increased MUC5AC mRNA expression and transcriptional activities of MUC5AC promoter-reporter deletion constructs containing AP-1 consensus sites.	Tetradecanoylphorbol Acetate	32-35	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	47-53
6411958-5	1983	Kinetic experiments indicated that IL-2 first became detectable at 2 hours in TPA-treated cultures, whereas in cultures stimulated with Con A alone IL-2 production was not evident until 8 hours.	Tetradecanoylphorbol Acetate	78-81	interleukin 2	Mus musculus	35-39
16773182-4	2006	Phorbol 12-myrisate 13-acetate (PMA) increased MUC5AC mRNA expression and transcriptional activities of MUC5AC promoter-reporter deletion constructs containing AP-1 consensus sites.	Tetradecanoylphorbol Acetate	32-35	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	104-110
6411958-6	1983	Flow cytometry indicated that TPA and its related phorbol esters cause a perturbation in the cycling of the cell which may be related to increased IL-2 production.	Tetradecanoylphorbol Acetate	30-33	interleukin 2	Mus musculus	147-151
16368122-5	2006	Arsenic/TPA treatment resulted in increased expression of alpha-fetoprotein, k-ras, c-myc, estrogen receptor-alpha, cyclin D1, cdk2na, plasminogen activator inhibitor-1, cytokeratin-8, cytokeratin-18, glutathione S-transferases and insulin-like growth factor binding proteins in liver and liver tumors from both male and female mice.	Tetradecanoylphorbol Acetate	8-11	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	77-82
6603367-1	1983	The effect of concanavalin A (Con A) and/or phorbol myristate acetate (PMA) on interleukin 2 (IL 2) production and tritiated thymidine incorporation was measured in young (6 weeks) and old (16-24 weeks) autoimmune mice by pulsing 5 X 10(6) unfractionated spleen cells with 5 micrograms of Con A and/or 5 ng of PMA for variable periods of time.	Tetradecanoylphorbol Acetate	44-69	interleukin 2	Mus musculus	79-92
16368122-5	2006	Arsenic/TPA treatment resulted in increased expression of alpha-fetoprotein, k-ras, c-myc, estrogen receptor-alpha, cyclin D1, cdk2na, plasminogen activator inhibitor-1, cytokeratin-8, cytokeratin-18, glutathione S-transferases and insulin-like growth factor binding proteins in liver and liver tumors from both male and female mice.	Tetradecanoylphorbol Acetate	8-11	estrogen receptor 1 (alpha)	Mus musculus	91-114
16368122-5	2006	Arsenic/TPA treatment resulted in increased expression of alpha-fetoprotein, k-ras, c-myc, estrogen receptor-alpha, cyclin D1, cdk2na, plasminogen activator inhibitor-1, cytokeratin-8, cytokeratin-18, glutathione S-transferases and insulin-like growth factor binding proteins in liver and liver tumors from both male and female mice.	Tetradecanoylphorbol Acetate	8-11	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	127-168
16368122-5	2006	Arsenic/TPA treatment resulted in increased expression of alpha-fetoprotein, k-ras, c-myc, estrogen receptor-alpha, cyclin D1, cdk2na, plasminogen activator inhibitor-1, cytokeratin-8, cytokeratin-18, glutathione S-transferases and insulin-like growth factor binding proteins in liver and liver tumors from both male and female mice.	Tetradecanoylphorbol Acetate	8-11	keratin 8	Mus musculus	170-183
16368122-6	2006	Arsenic/TPA also decreased the expression of BRCA1, betaine-homocysteine methyltransferase, CYP7B1, CYP2F2 and insulin-like growth factor-1 in normal and cancerous livers.	Tetradecanoylphorbol Acetate	8-11	cytochrome P450, family 2, subfamily f, polypeptide 2	Mus musculus	100-106
15826073-7	2005	Lingonberry extract also prevented TPA-induced phosphorylation of ERK1, ERK2, and MEK1/2.	Tetradecanoylphorbol Acetate	35-38	mitogen-activated protein kinase kinase 1	Homo sapiens	82-88
15790882-10	2005	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element.	Tetradecanoylphorbol Acetate	15-51	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	175-180
15790882-10	2005	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element.	Tetradecanoylphorbol Acetate	53-56	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	175-180
6603367-1	1983	The effect of concanavalin A (Con A) and/or phorbol myristate acetate (PMA) on interleukin 2 (IL 2) production and tritiated thymidine incorporation was measured in young (6 weeks) and old (16-24 weeks) autoimmune mice by pulsing 5 X 10(6) unfractionated spleen cells with 5 micrograms of Con A and/or 5 ng of PMA for variable periods of time.	Tetradecanoylphorbol Acetate	71-74	interleukin 2	Mus musculus	79-92
15828232-5	2005	In addition, the phorbol myristate acetate (PMA)-stimulated 22 kDa-subunit (p22phox) protein levels and 47 kDa-subunit (p47phox) protein levels in NADPH (superoxide generating enzyme nicotinamide adenine dinucleotide phosphate (reduced form)) oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	17-42	cytochrome b-245 alpha chain	Homo sapiens	76-83
15828232-5	2005	In addition, the phorbol myristate acetate (PMA)-stimulated 22 kDa-subunit (p22phox) protein levels and 47 kDa-subunit (p47phox) protein levels in NADPH (superoxide generating enzyme nicotinamide adenine dinucleotide phosphate (reduced form)) oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	17-42	peroxisome proliferator activated receptor alpha	Homo sapiens	284-293
16493010-2	2006	Annexin 2 (A2) is a profibrinolytic endothelial cell surface receptor that binds plasminogen, its tissue activator (tPA), and beta(2)-glycoprotein I (beta2GPI), the main antigen for antiphospholipid antibodies.	Tetradecanoylphorbol Acetate	116-119	annexin A2	Homo sapiens	0-9
6603367-1	1983	The effect of concanavalin A (Con A) and/or phorbol myristate acetate (PMA) on interleukin 2 (IL 2) production and tritiated thymidine incorporation was measured in young (6 weeks) and old (16-24 weeks) autoimmune mice by pulsing 5 X 10(6) unfractionated spleen cells with 5 micrograms of Con A and/or 5 ng of PMA for variable periods of time.	Tetradecanoylphorbol Acetate	71-74	interleukin 2	Mus musculus	94-98
16493010-2	2006	Annexin 2 (A2) is a profibrinolytic endothelial cell surface receptor that binds plasminogen, its tissue activator (tPA), and beta(2)-glycoprotein I (beta2GPI), the main antigen for antiphospholipid antibodies.	Tetradecanoylphorbol Acetate	116-119	annexin A2	Homo sapiens	11-13
16493010-6	2006	Anti-A2 IgG enhanced the expression of tissue factor on endothelial cells (6.4-fold +/- 0.13-fold SE), blocked A2-supported plasmin generation in a tPA-dependent generation assay (19%-71%) independently of beta2GPI, and inhibited cell surface plasmin generation on human umbilical vein endothelial cells (HUVECs) by 34% to 83%.	Tetradecanoylphorbol Acetate	148-151	annexin A2	Homo sapiens	5-7
16493010-6	2006	Anti-A2 IgG enhanced the expression of tissue factor on endothelial cells (6.4-fold +/- 0.13-fold SE), blocked A2-supported plasmin generation in a tPA-dependent generation assay (19%-71%) independently of beta2GPI, and inhibited cell surface plasmin generation on human umbilical vein endothelial cells (HUVECs) by 34% to 83%.	Tetradecanoylphorbol Acetate	148-151	annexin A2	Homo sapiens	111-113
15828232-5	2005	In addition, the phorbol myristate acetate (PMA)-stimulated 22 kDa-subunit (p22phox) protein levels and 47 kDa-subunit (p47phox) protein levels in NADPH (superoxide generating enzyme nicotinamide adenine dinucleotide phosphate (reduced form)) oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	44-47	cytochrome b-245 alpha chain	Homo sapiens	76-83
15828232-5	2005	In addition, the phorbol myristate acetate (PMA)-stimulated 22 kDa-subunit (p22phox) protein levels and 47 kDa-subunit (p47phox) protein levels in NADPH (superoxide generating enzyme nicotinamide adenine dinucleotide phosphate (reduced form)) oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	44-47	peroxisome proliferator activated receptor alpha	Homo sapiens	284-293
6601110-1	1983	The tumor-promoting phorbol ester, 12-0-tetradecanoyl-phorbol-13-acetate (TPA), stimulates starch-elicited mouse peritoneal macrophages to undergo DNA synthesis in vitro, apparently without the generation of an endogenous macrophage growth factor (MGF).	Tetradecanoylphorbol Acetate	74-77	kit ligand	Mus musculus	248-251
16633352-4	2006	MSP effects were compared with those induced by known AM stimuli, for example, phorbol myristate acetate, N-formyl-methionyl-leucyl-phenylalanine, lipopolysaccharide.MSP evokes O(2)(-) production, cytokine release and NF-kappaB activation in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	79-104	macrophage stimulating 1	Homo sapiens	166-169
6401187-1	1983	In order to obtain an anti-interleukin 2 (IL 2) receptor antibody, we immunized mice with phorbol myristate acetate-pulsed rat T lymphoblasts.	Tetradecanoylphorbol Acetate	90-115	interleukin 2	Mus musculus	27-40
15994005-5	2006	In addition, bicyclol attenuated TPA-induced IkappaB-alpha degradation.	Tetradecanoylphorbol Acetate	33-36	NFKB inhibitor alpha	Rattus norvegicus	45-58
15640523-2	2005	Here we show that phorbol myristate acetate (PMA) and tert-butylhydroquinone (tBHQ), which induce oxidative stress in cells, up-regulate transcription of Galpha(i2) in K562 cells.	Tetradecanoylphorbol Acetate	18-43	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	154-163
15640523-2	2005	Here we show that phorbol myristate acetate (PMA) and tert-butylhydroquinone (tBHQ), which induce oxidative stress in cells, up-regulate transcription of Galpha(i2) in K562 cells.	Tetradecanoylphorbol Acetate	45-48	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	154-163
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	36-73	toll like receptor 4	Homo sapiens	28-32
6401187-1	1983	In order to obtain an anti-interleukin 2 (IL 2) receptor antibody, we immunized mice with phorbol myristate acetate-pulsed rat T lymphoblasts.	Tetradecanoylphorbol Acetate	90-115	interleukin 2	Mus musculus	42-46
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	75-78	toll like receptor 4	Homo sapiens	28-32
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	75-78	toll like receptor 4	Homo sapiens	174-178
16675557-3	2006	EXPERIMENTAL DESIGN: Reverse transcription-PCR, flow cytometry, and immunohistochemistry were used to determine expression of Mer in sorted human thymocyte populations, lymphocytes, and lymphocytes activated by phytohemagglutinin or phorbol 12-myristate 13-acetate/ionophore.	Tetradecanoylphorbol Acetate	233-264	MER proto-oncogene, tyrosine kinase	Homo sapiens	126-129
6959135-2	1982	Over the same concentration range, 10(-9) to 10(-6) M, TPA induced the release of radioactively labeled fibronectin (FN) from the cells into the culture medium.	Tetradecanoylphorbol Acetate	55-58	fibronectin 1	Mus musculus	104-115
16675557-5	2006	RESULTS: Mer expression was absent in normal thymocytes or lymphocytes, and in T cells activated with phytohemagglutinin or phorbol 12-myristate 13-acetate/ionophore.	Tetradecanoylphorbol Acetate	124-155	MER proto-oncogene, tyrosine kinase	Homo sapiens	9-12
16614396-7	2006	CP at the same doses inhibited TPA-induced nuclear translocation of p65 and subsequent DNA binding of NF-kappaB at 1 h by blocking the degradation of IkappaBalpha in mouse skin.	Tetradecanoylphorbol Acetate	31-34	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	68-71
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	149-152	toll like receptor 4	Homo sapiens	28-32
15670752-2	2005	Though induction of TLR2 or TLR4 by 12-O-tetradecanoyl phorbol 13-acetate (TPA) in leukemia cells has been reported, however, the mechanism by which TPA up-regulates TLR2 or TLR4 remains poorly understood.	Tetradecanoylphorbol Acetate	149-152	toll like receptor 4	Homo sapiens	174-178
6959135-2	1982	Over the same concentration range, 10(-9) to 10(-6) M, TPA induced the release of radioactively labeled fibronectin (FN) from the cells into the culture medium.	Tetradecanoylphorbol Acetate	55-58	fibronectin 1	Mus musculus	117-119
6959135-3	1982	Retinoic acid, a derivative of vitamin A, inhibited in a dose-dependent manner both the increase in OrnDCase activity and the release of FN induced by TPA.	Tetradecanoylphorbol Acetate	151-154	fibronectin 1	Mus musculus	137-139
6959135-5	1982	In the enucleated cells, TPA did not induce increased OrnDCase activity but did induce FN release in a dose-dependent fashion over the same concentration range effective for FN release from intact cells.	Tetradecanoylphorbol Acetate	25-28	fibronectin 1	Mus musculus	87-89
15698597-16	2005	L-cystathionine and N-acetyl-L-cysteine suppressed fMLP- and PMA-induced superoxide generation by the inhibition of translocation to membrane of p47(phox) and p67(phox).	Tetradecanoylphorbol Acetate	61-64	pleckstrin	Homo sapiens	145-154
16489124-3	2006	In addition, Dexras1 significantly reduced phorbol 12-myristate 13-acetate (PMA)-stimulated AC2 activity but did not alter Galpha(s)-mediated cAMP accumulation.	Tetradecanoylphorbol Acetate	43-74	ras related dexamethasone induced 1	Homo sapiens	13-20
16489124-3	2006	In addition, Dexras1 significantly reduced phorbol 12-myristate 13-acetate (PMA)-stimulated AC2 activity but did not alter Galpha(s)-mediated cAMP accumulation.	Tetradecanoylphorbol Acetate	76-79	ras related dexamethasone induced 1	Homo sapiens	13-20
15698597-16	2005	L-cystathionine and N-acetyl-L-cysteine suppressed fMLP- and PMA-induced superoxide generation by the inhibition of translocation to membrane of p47(phox) and p67(phox).	Tetradecanoylphorbol Acetate	61-64	pleckstrin	Homo sapiens	149-153
6959135-5	1982	In the enucleated cells, TPA did not induce increased OrnDCase activity but did induce FN release in a dose-dependent fashion over the same concentration range effective for FN release from intact cells.	Tetradecanoylphorbol Acetate	25-28	fibronectin 1	Mus musculus	174-176
16480936-6	2006	In the process of Glu-Plasminogen activation, we found an increase in plasmin generation both at fibrin and cellular surface level as a function of the concentration of beta2GPI added, suggesting an important role as a cofactor in the trimolecular complex beta2GPI-Plasminogen-tPA.	Tetradecanoylphorbol Acetate	277-280	apolipoprotein H	Homo sapiens	169-177
6284358-10	1982	EGF receptors are clearly not necessary for TPA promotion of anchorage independence in JB6 cells but may mediate mitogenic stimulation of these cells by TPA.	Tetradecanoylphorbol Acetate	153-156	epidermal growth factor	Homo sapiens	0-3
7116338-0	1982	Dissociation of 12-O-tetradecanoylphorbol-13-acetate and 3-methylcholanthrene-induced induction in ornithine decarboxylase and aryl hydrocarbon hydroxylase activities in C57BL/6 mouse dermal fibroblasts in culture.	Tetradecanoylphorbol Acetate	16-52	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	127-155
16624193-6	2006	DMBA (Dimethylebenz[a] Anthracene) and TPA (Tetradecanoyl-phorbal-13-Acetic Acid) [chemical carcinogens] were given to produce the tumors and mutation of p53 expression was evaluated on the tumors appearing during this period of carcinogenesis.	Tetradecanoylphorbol Acetate	39-42	transformation related protein 53, pseudogene	Mus musculus	154-157
15543559-7	2005	Moreover, forskolin reduced the p38 MAP kinase phosphorylation induced by the 12-O-tetradecanoylphorbol-13-acetate (TPA), a PKC-activating phorbol ester, and significantly suppressed the TPA-stimulated accumulation of HSP27.	Tetradecanoylphorbol Acetate	116-119	heat shock protein family B (small) member 1	Homo sapiens	218-223
7116338-1	1982	The effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) and 3-methyl-cholanthrene (MC) on ornithine decarboxylase (ODC) and aryl hydrocarbon hydroxylase (AHH) activities were studied in C57BL/6 mouse dermal fibroblasts in culture.	Tetradecanoylphorbol Acetate	53-56	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	126-154
6170682-1	1981	Two growth factors, interleukin 2 (T cell growth factor) and colony-stimulating factor, are produced concomitantly by a murine EL-4 thymoma cell line after stimulation by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	171-196	interleukin 2	Mus musculus	20-33
15654655-7	2005	In particular, pre-treatment with phorbol 12-myristate 13-acetate (PMA) prevents the nuclear accumulation of FGF-2 and FGFR2 in response to PGF(2alpha).	Tetradecanoylphorbol Acetate	34-65	fibroblast growth factor receptor 2	Homo sapiens	119-124
15654655-7	2005	In particular, pre-treatment with phorbol 12-myristate 13-acetate (PMA) prevents the nuclear accumulation of FGF-2 and FGFR2 in response to PGF(2alpha).	Tetradecanoylphorbol Acetate	67-70	fibroblast growth factor receptor 2	Homo sapiens	119-124
16515541-0	2006	Up-regulation of tyrosine hydroxylase gene transcription by tetradecanoylphorbol acetate is mediated by the transcription factors Ets-like protein-1 (Elk-1) and Egr-1.	Tetradecanoylphorbol Acetate	60-88	ELK1, member of ETS oncogene family	Mus musculus	130-148
16515541-0	2006	Up-regulation of tyrosine hydroxylase gene transcription by tetradecanoylphorbol acetate is mediated by the transcription factors Ets-like protein-1 (Elk-1) and Egr-1.	Tetradecanoylphorbol Acetate	60-88	ELK1, member of ETS oncogene family	Mus musculus	150-155
16515541-0	2006	Up-regulation of tyrosine hydroxylase gene transcription by tetradecanoylphorbol acetate is mediated by the transcription factors Ets-like protein-1 (Elk-1) and Egr-1.	Tetradecanoylphorbol Acetate	60-88	early growth response 1	Mus musculus	161-166
6170682-1	1981	Two growth factors, interleukin 2 (T cell growth factor) and colony-stimulating factor, are produced concomitantly by a murine EL-4 thymoma cell line after stimulation by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	171-196	interleukin 2	Mus musculus	35-56
16515541-3	2006	We have analysed the stimulation of tyrosine hydroxylase gene transcription by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in noradrenergic locus coeruleus-like CATH.a cells and observed a striking enhancement of the transcriptional activation potential of the ternary complex factor Ets-like protein-1 (Elk-1), a key transcriptional regulator of serum response element-driven gene transcription.	Tetradecanoylphorbol Acetate	135-138	ELK1, member of ETS oncogene family	Mus musculus	301-319
16515541-3	2006	We have analysed the stimulation of tyrosine hydroxylase gene transcription by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in noradrenergic locus coeruleus-like CATH.a cells and observed a striking enhancement of the transcriptional activation potential of the ternary complex factor Ets-like protein-1 (Elk-1), a key transcriptional regulator of serum response element-driven gene transcription.	Tetradecanoylphorbol Acetate	135-138	ELK1, member of ETS oncogene family	Mus musculus	321-326
15627980-7	2005	Transcription inhibitors actinomycin D and 5,6-dichlororibofuranosyl benzimidazole, and the translation inhibitor cycloheximide significantly rescue the accumulation of CIITA mRNA in TPA-treated cells.	Tetradecanoylphorbol Acetate	183-186	class II major histocompatibility complex transactivator	Homo sapiens	169-174
15627980-9	2005	The instability of CIITA mRNA produced by TPA in U937 cells is not seen in B cells.	Tetradecanoylphorbol Acetate	42-45	class II major histocompatibility complex transactivator	Homo sapiens	19-24
6265908-3	1981	12-O-Tetradecanoylphorbol 13-acetate also produced an increase in enzyme activity in these cells and exhibited an additive effect with EGF.	Tetradecanoylphorbol Acetate	0-36	epidermal growth factor	Homo sapiens	135-138
15684381-7	2005	The IRES activity of p27(Kip1) mRNA in HL60 cells was increased by TPA treatment (with a concomitant increase in PTB protein levels), but the levels of p27(Kip1) mRNA remained unchanged.	Tetradecanoylphorbol Acetate	67-70	interferon alpha inducible protein 27	Homo sapiens	21-24
16515541-7	2006	Expression of dominant-negative mutants of Elk-1 or Egr-1 impaired TPA-induced stimulation of a tyrosine hydroxylase promoter/reporter gene transcription.	Tetradecanoylphorbol Acetate	67-70	ELK1, member of ETS oncogene family	Mus musculus	43-48
16515541-7	2006	Expression of dominant-negative mutants of Elk-1 or Egr-1 impaired TPA-induced stimulation of a tyrosine hydroxylase promoter/reporter gene transcription.	Tetradecanoylphorbol Acetate	67-70	early growth response 1	Mus musculus	52-57
16571380-3	2006	A similar upregulation of SK-1 is also observed with the direct protein kinase C activator 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	91-127	sphingosine kinase 1	Homo sapiens	26-30
15684381-7	2005	The IRES activity of p27(Kip1) mRNA in HL60 cells was increased by TPA treatment (with a concomitant increase in PTB protein levels), but the levels of p27(Kip1) mRNA remained unchanged.	Tetradecanoylphorbol Acetate	67-70	cyclin dependent kinase inhibitor 1B	Homo sapiens	25-29
7273309-5	1981	TPA also markedly enhanced the expression, in crowded cultures, of HPRT- mutants induced by the carcinogen N-methyl-N-nitrosourea.	Tetradecanoylphorbol Acetate	0-3	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	67-71
15455341-6	2005	We first determined the effect of topical application of PFE to CD-1 mice against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced conventional markers and other novel markers of skin tumor promotion.	Tetradecanoylphorbol Acetate	82-118	CD1 antigen complex	Mus musculus	64-68
15455341-6	2005	We first determined the effect of topical application of PFE to CD-1 mice against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced conventional markers and other novel markers of skin tumor promotion.	Tetradecanoylphorbol Acetate	120-123	CD1 antigen complex	Mus musculus	64-68
15455341-8	2005	We also found that topical application of PFE resulted in inhibition of TPA-induced phosphorylation of ERK1/2, p38 and JNK1/2, as well as activation of NF-kappaB and IKKalpha and phosphorylation and degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	72-75	conserved helix-loop-helix ubiquitous kinase	Mus musculus	166-174
16571380-3	2006	A similar upregulation of SK-1 is also observed with the direct protein kinase C activator 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	129-132	sphingosine kinase 1	Homo sapiens	26-30
16571380-6	2006	Moreover, the increased SK-1 mRNA expression results from an increased promoter activation by histamine and TPA.	Tetradecanoylphorbol Acetate	108-111	sphingosine kinase 1	Homo sapiens	24-28
16571380-7	2006	In mechanistic terms, the transcriptional upregulation of SK-1 is dependent on PKC and the extracellular signal-regulated protein kinase (ERK) cascade since staurosporine and the MEK inhibitor U0126 abolish the TPA-induced SK-1 induction.	Tetradecanoylphorbol Acetate	211-214	sphingosine kinase 1	Homo sapiens	58-62
16571380-9	2006	Parallel to the induction of SK-1, histamine and TPA stimulate an increased migration of endothelial cells, which is prevented by depletion of the SK-1 by small interfering RNA (siRNA).	Tetradecanoylphorbol Acetate	49-52	sphingosine kinase 1	Homo sapiens	147-151
16571380-11	2006	Interestingly, only depletion of PKC-alpha leads to a complete loss of TPA- and histamine-triggered SK-1 induction and cell migration.	Tetradecanoylphorbol Acetate	71-74	sphingosine kinase 1	Homo sapiens	100-104
16244358-0	2006	Attenuation of BPDE-induced p53 accumulation by TPA is associated with a decrease in stability and phosphorylation of p53 and downregulation of NFkappaB activation: role of p38 MAP kinase.	Tetradecanoylphorbol Acetate	48-51	transformation related protein 53, pseudogene	Mus musculus	28-31
16244358-0	2006	Attenuation of BPDE-induced p53 accumulation by TPA is associated with a decrease in stability and phosphorylation of p53 and downregulation of NFkappaB activation: role of p38 MAP kinase.	Tetradecanoylphorbol Acetate	48-51	transformation related protein 53, pseudogene	Mus musculus	118-121
16244358-2	2006	12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits p53 response induced by B[a]P and other DNA-damaging agents and may cause tumor promotion.	Tetradecanoylphorbol Acetate	0-36	transformation related protein 53, pseudogene	Mus musculus	52-55
6968789-1	1980	Phorbol-12-myristate-13-acetate stimulates a subline of mouse EL-4 thymoma cells to produce, in vitro, in very high titer, T cell growth factor (Interleukin 2, IL 2).	Tetradecanoylphorbol Acetate	0-31	interleukin 2	Mus musculus	123-143
16244358-2	2006	12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits p53 response induced by B[a]P and other DNA-damaging agents and may cause tumor promotion.	Tetradecanoylphorbol Acetate	38-41	transformation related protein 53, pseudogene	Mus musculus	52-55
16244358-3	2006	The molecular mechanism of attenuation of B[a]P-induced p53 response by TPA is not known.	Tetradecanoylphorbol Acetate	72-75	transformation related protein 53, pseudogene	Mus musculus	56-59
16244358-4	2006	We investigated the effect of TPA on p53 response in (+/-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE)-treated mouse epidermal JB6(P(+)) Cl 41 cells.	Tetradecanoylphorbol Acetate	30-33	transformation related protein 53, pseudogene	Mus musculus	37-40
6968789-1	1980	Phorbol-12-myristate-13-acetate stimulates a subline of mouse EL-4 thymoma cells to produce, in vitro, in very high titer, T cell growth factor (Interleukin 2, IL 2).	Tetradecanoylphorbol Acetate	0-31	interleukin 2	Mus musculus	145-158
15358594-8	2005	The pharmacological agonists phorbol 12-myristate 13-acetate and carbachol also led to the translocation of PKC-epsilon.	Tetradecanoylphorbol Acetate	29-60	protein kinase C epsilon	Homo sapiens	108-119
6968789-1	1980	Phorbol-12-myristate-13-acetate stimulates a subline of mouse EL-4 thymoma cells to produce, in vitro, in very high titer, T cell growth factor (Interleukin 2, IL 2).	Tetradecanoylphorbol Acetate	0-31	interleukin 2	Mus musculus	160-164
16342171-3	2006	Using the monocytic cell line U937, we were able to demonstrate that MAF is upregulated after TPA-induced differentiation into macrophages.	Tetradecanoylphorbol Acetate	94-97	avian musculoaponeurotic fibrosarcoma oncogene homolog	Mus musculus	69-72
6968790-7	1980	Peak IL-2 production by LBRM-33 cultures (stimulated at either optimal Con A or PHA concentrations or co-stimulated with suboptimal amounts of mitogen and phorbol myristate acetate) was consistently accompanied by LBRM-33 cell death.	Tetradecanoylphorbol Acetate	155-180	interleukin 2	Mus musculus	5-9
11272120-7	1980	Taken together, our results suggest that TPA inhibition of EGF-receptor binding results from TPA-induced changes in the membrane microenvironment of EGF receptors.	Tetradecanoylphorbol Acetate	41-44	epidermal growth factor	Homo sapiens	59-62
16520553-1	2006	Elevated expression of protein casein kinase II (CKII) stimulated basal phospholipase D (PLD) activity as well as PMA-induced PLD activation in human U87 astroglioma cells.	Tetradecanoylphorbol Acetate	114-117	casein kinase 2 alpha 1	Homo sapiens	31-47
16491951-0	2005	Overexpression of extracellular superoxide dismutase (EC-SOD) in mouse skin plays a protective role in DMBA/TPA-induced tumor formation.	Tetradecanoylphorbol Acetate	108-111	superoxide dismutase 3, extracellular	Mus musculus	18-52
16491951-0	2005	Overexpression of extracellular superoxide dismutase (EC-SOD) in mouse skin plays a protective role in DMBA/TPA-induced tumor formation.	Tetradecanoylphorbol Acetate	108-111	superoxide dismutase 3, extracellular	Mus musculus	54-60
11272120-7	1980	Taken together, our results suggest that TPA inhibition of EGF-receptor binding results from TPA-induced changes in the membrane microenvironment of EGF receptors.	Tetradecanoylphorbol Acetate	41-44	epidermal growth factor	Homo sapiens	149-152
16520553-1	2006	Elevated expression of protein casein kinase II (CKII) stimulated basal phospholipase D (PLD) activity as well as PMA-induced PLD activation in human U87 astroglioma cells.	Tetradecanoylphorbol Acetate	114-117	casein kinase 2 alpha 1	Homo sapiens	49-53
11272120-7	1980	Taken together, our results suggest that TPA inhibition of EGF-receptor binding results from TPA-induced changes in the membrane microenvironment of EGF receptors.	Tetradecanoylphorbol Acetate	93-96	epidermal growth factor	Homo sapiens	59-62
15789612-4	2005	PGE2 increased both the PMA-induced cell adhesion and MMP-9 production via EP2/EP4 receptors while it had no effect on the induced TNF-alpha release.	Tetradecanoylphorbol Acetate	24-27	prostaglandin E receptor 4	Homo sapiens	79-82
11272120-7	1980	Taken together, our results suggest that TPA inhibition of EGF-receptor binding results from TPA-induced changes in the membrane microenvironment of EGF receptors.	Tetradecanoylphorbol Acetate	93-96	epidermal growth factor	Homo sapiens	149-152
15625014-3	2004	In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect.	Tetradecanoylphorbol Acetate	192-228	colony stimulating factor 2	Homo sapiens	63-111
16373364-4	2006	Transcription of IL-5 reporter gene plasmids could be induced in D10 cells by phorbol myristate acetate/cyclic adenosine monophosphate (PMA/cAMP) stimulation and significantly further enhanced by activation of the mitogen-activated protein (MAP) kinase pathways.	Tetradecanoylphorbol Acetate	78-103	interleukin 5	Mus musculus	17-21
16373364-4	2006	Transcription of IL-5 reporter gene plasmids could be induced in D10 cells by phorbol myristate acetate/cyclic adenosine monophosphate (PMA/cAMP) stimulation and significantly further enhanced by activation of the mitogen-activated protein (MAP) kinase pathways.	Tetradecanoylphorbol Acetate	136-139	interleukin 5	Mus musculus	17-21
15625014-3	2004	In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect.	Tetradecanoylphorbol Acetate	192-228	colony stimulating factor 2	Homo sapiens	113-119
16373364-5	2006	Strong induction of IL-5 mRNA was also induced by PMA/cAMP.	Tetradecanoylphorbol Acetate	50-53	interleukin 5	Mus musculus	20-24
16068160-1	1979	TPA (12-O-tetradecanoyl-phorbol-13-acetate) reversibly inhibits the binding of (125)I-labelled epidermal growth factor (EGF) to treated mouse and human cells, but does not affect the binding of various other ligands to their membrane receptors.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor	Mus musculus	95-118
15625014-3	2004	In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect.	Tetradecanoylphorbol Acetate	230-233	colony stimulating factor 2	Homo sapiens	63-111
15625014-3	2004	In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect.	Tetradecanoylphorbol Acetate	230-233	colony stimulating factor 2	Homo sapiens	113-119
16068160-1	1979	TPA (12-O-tetradecanoyl-phorbol-13-acetate) reversibly inhibits the binding of (125)I-labelled epidermal growth factor (EGF) to treated mouse and human cells, but does not affect the binding of various other ligands to their membrane receptors.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor	Mus musculus	120-123
16404705-5	2006	A single topical application of TPA to ears of CD-1 mice induced a time- and dose-dependent increase in edema as well as formation of proinflammatory cytokine proteins interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in mouse ears.	Tetradecanoylphorbol Acetate	32-35	CD1 antigen complex	Mus musculus	47-51
16068160-1	1979	TPA (12-O-tetradecanoyl-phorbol-13-acetate) reversibly inhibits the binding of (125)I-labelled epidermal growth factor (EGF) to treated mouse and human cells, but does not affect the binding of various other ligands to their membrane receptors.	Tetradecanoylphorbol Acetate	5-42	epidermal growth factor	Mus musculus	95-118
33140258-5	2021	Potential pathologic factors that are related to the suboptimal tPA recanalization in diabetic stroke include higher plasma plasminogen activator inhibitor (PAI)-1 level, diabetic atherogenic vascular damage, glycation of the tPA receptor annexin A2, and alterations in fibrin clot density.	Tetradecanoylphorbol Acetate	64-67	serpin family E member 1	Homo sapiens	124-163
16243536-11	2006	HO-1 induction was blocked by the protein kinase C inhibitors calphostin C, rottlerin, and long PMA pretreatment, whereas conventional PKC inhibitors, Go6976, and Ca2+ chelator BAPTA/AM, had no effect.	Tetradecanoylphorbol Acetate	96-99	heme oxygenase 1	Homo sapiens	0-4
16283633-6	2006	Injection of phorbolmyristate acetate (PMA), an activator of protein kinase C (PKC) that in turn upregulates OPG expression, also delayed eruption by 1 day.	Tetradecanoylphorbol Acetate	13-37	TNF receptor superfamily member 11B	Rattus norvegicus	109-112
15654514-4	2004	RESULTS: HMC-1 produced substantial amounts of GM-CSF and IL-8 and smaller amounts of TNF-alpha, IL-4 and IL-6 after being stimulated with PMA together with A23187.	Tetradecanoylphorbol Acetate	139-142	colony stimulating factor 2	Homo sapiens	47-53
33140258-5	2021	Potential pathologic factors that are related to the suboptimal tPA recanalization in diabetic stroke include higher plasma plasminogen activator inhibitor (PAI)-1 level, diabetic atherogenic vascular damage, glycation of the tPA receptor annexin A2, and alterations in fibrin clot density.	Tetradecanoylphorbol Acetate	64-67	annexin A2	Homo sapiens	239-249
16283633-6	2006	Injection of phorbolmyristate acetate (PMA), an activator of protein kinase C (PKC) that in turn upregulates OPG expression, also delayed eruption by 1 day.	Tetradecanoylphorbol Acetate	39-42	TNF receptor superfamily member 11B	Rattus norvegicus	109-112
34021237-11	2021	Increasing experimental evidence has proven that CpG and TpA are targeted by innate antiviral host defences, contributing both to RNA degradation and RIG-1 mediated interferon production.	Tetradecanoylphorbol Acetate	57-60	roundabout guidance receptor 3	Homo sapiens	150-155
16365389-4	2006	Furthermore, tissue-specific junB knockout mice respond to 12-O-tetradecanoyl-phorbol-13-acetate, a potent AP-1 activator, with markedly increased and sustained epidermal RAE-1epsilon expression.	Tetradecanoylphorbol Acetate	59-96	jun B proto-oncogene	Mus musculus	29-33
16365389-4	2006	Furthermore, tissue-specific junB knockout mice respond to 12-O-tetradecanoyl-phorbol-13-acetate, a potent AP-1 activator, with markedly increased and sustained epidermal RAE-1epsilon expression.	Tetradecanoylphorbol Acetate	59-96	retinoic acid early transcript 1E	Mus musculus	171-183
15599091-6	2004	Protein kinase activators including phorbol 12-myristate 13-acetate (PMA), 8-bromo-cyclic GMP (8-Br-cGMP), and 8-bromo-cyclic AMP (8-Br-cAMP) induced increases in H1R phosphorylation.	Tetradecanoylphorbol Acetate	36-67	histamine receptor H1	Homo sapiens	163-166
15599091-7	2004	Increased phosphorylation of H1R, by 5-fold over the basal level, induced with a combination of PMA, 8-Br-cGMP, and 8-Br-cAMP was still lower than that with histamine.	Tetradecanoylphorbol Acetate	96-99	histamine receptor H1	Homo sapiens	29-32
33044016-11	2021	These results provide evidence that miR-1696 targeted GPx3 activities in neutrophils could be used to regulate the NETs formation stimulated by PMA.	Tetradecanoylphorbol Acetate	144-147	glutathione peroxidase 3	Gallus gallus	54-58
15533438-4	2004	We investigated the signalling pathway regulating phorbol 12-myristate 13-acetate (PMA)-induced MUC5AC gene and protein expression in human respiratory epithelial cells.	Tetradecanoylphorbol Acetate	50-81	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	96-102
15533438-4	2004	We investigated the signalling pathway regulating phorbol 12-myristate 13-acetate (PMA)-induced MUC5AC gene and protein expression in human respiratory epithelial cells.	Tetradecanoylphorbol Acetate	83-86	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	96-102
16409470-12	2006	Low tPA-PAI-1 was not associated with the increased bleeding tendency.	Tetradecanoylphorbol Acetate	4-7	serpin family E member 1	Homo sapiens	8-13
33871880-2	2021	In this study, two novel violet-blue bipolar fluorophores , TPA-PI-SBF and SBF-PI-SBF , were designed and synthesized by introducing the hole transporting moiety triphenylamine (TPA) and spirobifluorene (SBF) unit that has high T 1 into high deep blue emission quantum yield group phenanthroimidazole (PI).	Tetradecanoylphorbol Acetate	178-181	zinc finger protein 143	Homo sapiens	67-70
15981203-6	2005	The activities of cutaneous gamma-glutamyl transpeptidase (GGT) and glutathione-S-transferase P (GST-P), marker enzymes of tumorigenesis, were found to exhibit higher expression in AO or isolated sanguinarine/TPA treated groups when compared to control.	Tetradecanoylphorbol Acetate	209-212	glutathione S-transferase pi 1	Homo sapiens	68-95
15981203-6	2005	The activities of cutaneous gamma-glutamyl transpeptidase (GGT) and glutathione-S-transferase P (GST-P), marker enzymes of tumorigenesis, were found to exhibit higher expression in AO or isolated sanguinarine/TPA treated groups when compared to control.	Tetradecanoylphorbol Acetate	209-212	glutathione S-transferase pi 1	Homo sapiens	97-102
15356004-0	2004	Src tyrosine kinase inhibitor PP2 markedly enhances Ras-independent activation of Raf-1 protein kinase by phorbol myristate acetate and H2O2.	Tetradecanoylphorbol Acetate	106-131	neuropeptide Y receptor Y6	Mus musculus	30-33
15356004-7	2004	In this study we have demonstrated that PP2 (4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine), a potent and selective inhibitor of the Src-family tyrosine kinase, greatly potentiated the ability of PMA and/or H2O2 to activate Raf-1 kinase, whereas it blocked the tyrosine phosphorylation of Raf-1.	Tetradecanoylphorbol Acetate	214-217	neuropeptide Y receptor Y6	Mus musculus	40-43
15356004-14	2004	This PP2 effect resulted in significant and sustained Ras-independent activation of Raf-1 by PMA and H2O2.	Tetradecanoylphorbol Acetate	93-96	neuropeptide Y receptor Y6	Mus musculus	5-8
33871880-2	2021	In this study, two novel violet-blue bipolar fluorophores , TPA-PI-SBF and SBF-PI-SBF , were designed and synthesized by introducing the hole transporting moiety triphenylamine (TPA) and spirobifluorene (SBF) unit that has high T 1 into high deep blue emission quantum yield group phenanthroimidazole (PI).	Tetradecanoylphorbol Acetate	178-181	zinc finger protein 143	Homo sapiens	75-85
16223731-7	2005	Interestingly, protein expression of NIK is steadily induced by B cell-activating factor or CD40 ligand, two major physiological inducers of p100 processing, but not by mitogen phorbol 12-myristate 13-acetate/ionomycin or cytokine tumor necrosis factor alpha, two well known inducers of the canonical NF-kappaB signaling.	Tetradecanoylphorbol Acetate	177-208	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	37-40
33871880-2	2021	In this study, two novel violet-blue bipolar fluorophores , TPA-PI-SBF and SBF-PI-SBF , were designed and synthesized by introducing the hole transporting moiety triphenylamine (TPA) and spirobifluorene (SBF) unit that has high T 1 into high deep blue emission quantum yield group phenanthroimidazole (PI).	Tetradecanoylphorbol Acetate	178-181	zinc finger protein 143	Homo sapiens	75-78
33871880-6	2021	Additionally, the green, yellow and red phosphorescent OLEDs with TPA-PI-SBF and SBF-PI-SBF as host materials achieved a high EQE max of about 20% and low efficiency roll-off at the ultra-high luminance of 10 000 cd m -2 .	Tetradecanoylphorbol Acetate	66-69	zinc finger protein 143	Homo sapiens	73-76
16524842-12	2005	The expression of cyclin D1 and c-fos were detected only in the tumorous skin tissues of the TPA-treated group.	Tetradecanoylphorbol Acetate	93-96	FBJ osteosarcoma oncogene	Mus musculus	32-37
33865856-5	2021	In addition, carbachol and PMA induced translocation of monomeric GFP-mSK1 to lamellipodia, while S1P induced translocation of dimeric GFP-mSK1 to filopodia, suggesting that SK1 regulates different cell biological processes dependent on dimerization.	Tetradecanoylphorbol Acetate	27-30	sphingosine kinase 1	Homo sapiens	71-74
33992512-8	2021	In THP-1 cells treated with phorbol myristate acetate, GL inhibited the inflammatory polarization of macrophages (as evidenced by reduced TNF-alpha levels) via regulation of Notch1 and DLL4 pathways.	Tetradecanoylphorbol Acetate	28-53	delta like canonical Notch ligand 4	Homo sapiens	185-189
16323285-8	2005	Conversely, protein levels of manganese superoxide dismutase and the matrix metalloproteinases MMP-1 and MMP-9 were progressively increased in TPA-treated asPARP TUR cells, respectively.	Tetradecanoylphorbol Acetate	143-146	matrix metallopeptidase 1	Homo sapiens	95-100
15473955-8	2004	Bidimensional (IEF-SDS/PAGE) analysis showed that the combination of IL-5 treatment followed by stimulation with either PMA or STZ induced the formation of an additional, hyperphosphorylated form of p47(phox).	Tetradecanoylphorbol Acetate	120-123	pleckstrin	Homo sapiens	199-202
15666830-5	2004	TPA but not AII increased the level of the transcription factor JunB in nuclear extracts and the increase was partially abolished by the MEK1 inhibitor PD98059.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 1	Homo sapiens	137-141
15666830-7	2004	Taken together these results suggest that TPA inhibits the AII-dependent activation of CYP11B2 via the p44/42 MAPK signaling pathway leading to an increase of the level of nuclear JunB.	Tetradecanoylphorbol Acetate	42-45	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	87-94
33788722-4	2021	RESULTS: DMBA/TPA-induced skin carcinogenesis was suppressed in mPGES-1 KO mice.	Tetradecanoylphorbol Acetate	14-17	prostaglandin E synthase	Mus musculus	64-71
15375637-4	2004	Treatments known to induce FasL in mammalian systems (e.g., PMA/calcium ionophore, UV-irradiation) induced expression of the 37,000- Mr protein in catfish T-cell lines.	Tetradecanoylphorbol Acetate	60-63	Fas ligand	Homo sapiens	27-31
16211258-3	2005	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated the production of GM-CSF in a dose-dependent manner and reduced G-CSF in the cell lines.	Tetradecanoylphorbol Acetate	18-49	colony stimulating factor 2	Homo sapiens	85-91
16211258-3	2005	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated the production of GM-CSF in a dose-dependent manner and reduced G-CSF in the cell lines.	Tetradecanoylphorbol Acetate	18-49	colony stimulating factor 3	Homo sapiens	131-136
16211258-3	2005	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated the production of GM-CSF in a dose-dependent manner and reduced G-CSF in the cell lines.	Tetradecanoylphorbol Acetate	51-54	colony stimulating factor 2	Homo sapiens	85-91
16211258-3	2005	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated the production of GM-CSF in a dose-dependent manner and reduced G-CSF in the cell lines.	Tetradecanoylphorbol Acetate	51-54	colony stimulating factor 3	Homo sapiens	131-136
33788722-6	2021	CONCLUSION: mPGES-1 promotes chemically induced skin carcinogenesis and might play an important role in the TPA-induced promotion phase of the two-stage skin carcinogenesis model.	Tetradecanoylphorbol Acetate	108-111	prostaglandin E synthase	Mus musculus	12-19
15324351-8	2004	Tyrosine kinase inhibitor herbimycin A reduced MMP-1 production induced by PMA, whereas the p38 MAPK-inhibitor SB 203580 synergistically increased the stimulatory effect of PMA on both MMP-1 and TIMP-1 production.	Tetradecanoylphorbol Acetate	75-78	matrix metallopeptidase 1	Homo sapiens	47-52
33278786-1	2021	This study examined whether early life adversity (ELA) limited to infancy was associated with an increase in circulating levels of proinflammatory cytokines and cellular cytokine responses to three stimulants [lipopolysaccharide (LPS), phytohemagglutinin (PHA), and phorbol myristate acetate plus ionomycin (PMA/IO)].	Tetradecanoylphorbol Acetate	266-291	apelin receptor early endogenous ligand	Homo sapiens	50-53
15324351-8	2004	Tyrosine kinase inhibitor herbimycin A reduced MMP-1 production induced by PMA, whereas the p38 MAPK-inhibitor SB 203580 synergistically increased the stimulatory effect of PMA on both MMP-1 and TIMP-1 production.	Tetradecanoylphorbol Acetate	173-176	matrix metallopeptidase 1	Homo sapiens	185-190
15271977-8	2004	We examined the function of this Stat5-binding motif by transfecting human peripheral blood mononuclear cells with -3.6 kb of IFNG-luciferase constructs and found that phorbol 12-myristate 13-acetate/ionomycin-induced transcription was augmented by IL-2 treatment.	Tetradecanoylphorbol Acetate	168-199	signal transducer and activator of transcription 5A	Homo sapiens	33-38
16149074-3	2005	In this study, we observed that there was an early induction and a later repression of LDLR by phorbol ester (PMA) in SK-Hep1 hepatocarcinoma cells and investigated the mechanisms through which PMA repressed LDLR transcription.	Tetradecanoylphorbol Acetate	110-113	low density lipoprotein receptor	Homo sapiens	87-91
16149074-3	2005	In this study, we observed that there was an early induction and a later repression of LDLR by phorbol ester (PMA) in SK-Hep1 hepatocarcinoma cells and investigated the mechanisms through which PMA repressed LDLR transcription.	Tetradecanoylphorbol Acetate	194-197	low density lipoprotein receptor	Homo sapiens	87-91
16149074-3	2005	In this study, we observed that there was an early induction and a later repression of LDLR by phorbol ester (PMA) in SK-Hep1 hepatocarcinoma cells and investigated the mechanisms through which PMA repressed LDLR transcription.	Tetradecanoylphorbol Acetate	194-197	low density lipoprotein receptor	Homo sapiens	208-212
33278786-1	2021	This study examined whether early life adversity (ELA) limited to infancy was associated with an increase in circulating levels of proinflammatory cytokines and cellular cytokine responses to three stimulants [lipopolysaccharide (LPS), phytohemagglutinin (PHA), and phorbol myristate acetate plus ionomycin (PMA/IO)].	Tetradecanoylphorbol Acetate	308-311	apelin receptor early endogenous ligand	Homo sapiens	50-53
33381031-8	2020	Induction of HO-1 by ferric protoporphyrin IX (FePP) inhibited TPA-induced uPAR expression, and this effect was abolished by treatment with the HO-1 inhibitor tin protoporphyrin IX (SnPP).	Tetradecanoylphorbol Acetate	63-66	heme oxygenase 1	Homo sapiens	13-17
16227584-2	2005	We show that constitutive and phorbol 12-myristate 13-acetate-induced generation of soluble Axl (sAxl) involves the activity of disintegrin-like metalloproteinase 10 (ADAM10).	Tetradecanoylphorbol Acetate	30-61	AXL receptor tyrosine kinase	Mus musculus	92-95
16227584-2	2005	We show that constitutive and phorbol 12-myristate 13-acetate-induced generation of soluble Axl (sAxl) involves the activity of disintegrin-like metalloproteinase 10 (ADAM10).	Tetradecanoylphorbol Acetate	30-61	a disintegrin and metallopeptidase domain 10	Mus musculus	167-173
15365312-6	2004	Shedding of p75 and p55 TNF receptors (Mono Mac 6 cells) or L-selectin (Jurkat T cells) was induced by stimulation with lipopolysaccharide and phorbol myristate acetate for Mono Mac 6 cells and PMA alone for Jurkat T cells.	Tetradecanoylphorbol Acetate	143-168	TNF receptor superfamily member 1A	Homo sapiens	20-23
15365312-6	2004	Shedding of p75 and p55 TNF receptors (Mono Mac 6 cells) or L-selectin (Jurkat T cells) was induced by stimulation with lipopolysaccharide and phorbol myristate acetate for Mono Mac 6 cells and PMA alone for Jurkat T cells.	Tetradecanoylphorbol Acetate	143-168	selectin L	Homo sapiens	60-70
33381031-8	2020	Induction of HO-1 by ferric protoporphyrin IX (FePP) inhibited TPA-induced uPAR expression, and this effect was abolished by treatment with the HO-1 inhibitor tin protoporphyrin IX (SnPP).	Tetradecanoylphorbol Acetate	63-66	plasminogen activator, urokinase receptor	Homo sapiens	75-79
16199204-3	2005	Albumin pretreatment significantly reduced CD11b expression and L-selectin shedding induced by fMLP and ROS production induced by PMA, G-CSF combined with PMA or LPS-fMLP, or anti-HNA-1a combined with PMA.	Tetradecanoylphorbol Acetate	130-133	selectin L	Homo sapiens	64-74
33381031-8	2020	Induction of HO-1 by ferric protoporphyrin IX (FePP) inhibited TPA-induced uPAR expression, and this effect was abolished by treatment with the HO-1 inhibitor tin protoporphyrin IX (SnPP).	Tetradecanoylphorbol Acetate	63-66	heme oxygenase 1	Homo sapiens	144-148
33381031-9	2020	Additionally, carbon monoxide, an HO-1 product, attenuated TPA-induced uPAR expression and cell invasion.	Tetradecanoylphorbol Acetate	59-62	heme oxygenase 1	Homo sapiens	34-38
33381031-9	2020	Additionally, carbon monoxide, an HO-1 product, attenuated TPA-induced uPAR expression and cell invasion.	Tetradecanoylphorbol Acetate	59-62	plasminogen activator, urokinase receptor	Homo sapiens	71-75
15976015-2	2005	Inhibition of proliferation by TPA in PANC-1 cells was associated with an increase in the level of p21, but this was not observed in MIA PaCa-2 or BxPC-3 cells.	Tetradecanoylphorbol Acetate	31-34	H3 histone pseudogene 16	Homo sapiens	99-102
15976015-3	2005	The TPA-induced increase of p21 in PANC-1 cells was blocked by bisindolylmaleimide or rottlerin (inhibitors of protein kinase C).	Tetradecanoylphorbol Acetate	4-7	H3 histone pseudogene 16	Homo sapiens	28-31
33239616-8	2020	Consistently, we find that the CCL3-CCR5 axis suppresses PMA-induced enhancement of MMP-9 expression in macrophages.	Tetradecanoylphorbol Acetate	57-60	chemokine (C-C motif) ligand 3	Mus musculus	31-35
15976015-3	2005	The TPA-induced increase of p21 in PANC-1 cells was blocked by bisindolylmaleimide or rottlerin (inhibitors of protein kinase C).	Tetradecanoylphorbol Acetate	4-7	pancreas protein 1	Mus musculus	35-41
16043122-6	2005	CREB was activated by forskolin (10 microM), PMA (500 nM), and cyclical mechanical strain (1 Hz, 5% elongation) in fibroblasts.	Tetradecanoylphorbol Acetate	45-48	cAMP responsive element binding protein 1	Rattus norvegicus	0-4
15181005-6	2004	Whereas gp91(phox) activity required the protein kinase C activator phorbol myristate acetate (PMA), Nox3 activity was already high without PMA, but was further stimulated approximately 30% by PMA.	Tetradecanoylphorbol Acetate	68-93	inhibitor of growth family member 1	Homo sapiens	13-17
15181005-6	2004	Whereas gp91(phox) activity required the protein kinase C activator phorbol myristate acetate (PMA), Nox3 activity was already high without PMA, but was further stimulated approximately 30% by PMA.	Tetradecanoylphorbol Acetate	95-98	inhibitor of growth family member 1	Homo sapiens	13-17
15181005-6	2004	Whereas gp91(phox) activity required the protein kinase C activator phorbol myristate acetate (PMA), Nox3 activity was already high without PMA, but was further stimulated approximately 30% by PMA.	Tetradecanoylphorbol Acetate	140-143	NADPH oxidase 3	Homo sapiens	101-105
15181005-6	2004	Whereas gp91(phox) activity required the protein kinase C activator phorbol myristate acetate (PMA), Nox3 activity was already high without PMA, but was further stimulated approximately 30% by PMA.	Tetradecanoylphorbol Acetate	140-143	NADPH oxidase 3	Homo sapiens	101-105
32750368-6	2020	Phorbol myristate acetate increased alpha1A-adrenoceptor interaction with Rab5 and Rab9 but did not modify it with Rab7.	Tetradecanoylphorbol Acetate	0-25	RAB5A, member RAS oncogene family	Homo sapiens	74-78
15145978-3	2004	We show that while histone H3 is constitutively acetylated at LDL receptor chromatin, 12-O-tetradecanoylphorbol-13-acetate (TPA) causes rapid hyperphosphorylation of histone H3 on serine 10 (histone H3-Ser10), despite global reduction in its phosphorylation levels.	Tetradecanoylphorbol Acetate	124-127	low density lipoprotein receptor	Homo sapiens	62-74
15145978-5	2004	Interestingly, inhibition of protein kinase C (PKC) blocks Ser10 hyperphosphorylation and also compromises LDL receptor induction by TPA.	Tetradecanoylphorbol Acetate	133-136	low density lipoprotein receptor	Homo sapiens	107-119
16156860-4	2005	TPA-stimulated HEL cells normally undergo: (1) growth arrest; (2) altered morphology; (3) endomitosis and (4) characteristic changes in gene expression, including reduction of the erythroid-specific glycophoryn A and elevation of the specific glycoproteins GPIIIa and GPVI.	Tetradecanoylphorbol Acetate	0-3	glycoprotein VI platelet	Homo sapiens	268-272
16210792-5	2005	However, the transformation frequency for HFEMF at SAR of more than 100 W/kg with MC or MC plus TPA was increased compared with MC alone or MC plus TPA.	Tetradecanoylphorbol Acetate	96-99	sarcosinemia autosomal recessive	Mus musculus	51-54
31303127-8	2020	The increase (p <= 0.05) in protein expression of connexin-32 and 43 in LycT + DMBA/TPA group suggests improved inter cellular communication when compared to DMBA/TPA group.	Tetradecanoylphorbol Acetate	84-87	gap junction protein, beta 1	Mus musculus	50-61
16135804-4	2005	Our results demonstrate a binding of HuR to the SLC11A1 ARE in phorbol myristate acetate (PMA)-differentiated cells dramatically increased compared to that in undifferentiated cells.	Tetradecanoylphorbol Acetate	63-88	ELAV like RNA binding protein 1	Homo sapiens	37-40
16135804-4	2005	Our results demonstrate a binding of HuR to the SLC11A1 ARE in phorbol myristate acetate (PMA)-differentiated cells dramatically increased compared to that in undifferentiated cells.	Tetradecanoylphorbol Acetate	90-93	ELAV like RNA binding protein 1	Homo sapiens	37-40
16135804-5	2005	Interestingly, PMA-induced accumulation of cytoplasmic HuR occurs in parallel with an increase in the binding of HuR to SLC11A1 ARE and with an increase in the SLC11A1 mRNA level.	Tetradecanoylphorbol Acetate	15-18	ELAV like RNA binding protein 1	Homo sapiens	55-58
16099101-6	2005	The blockade of NK1, CGRP, NMDA, beta1-adrenergic, B2 or TRPV1 receptors with selective antagonists partially decreased PMA-induced nociception.	Tetradecanoylphorbol Acetate	120-123	killer cell lectin-like receptor subfamily B member 1C	Mus musculus	16-19
15231681-9	2004	Electrophoretic mobility shift analysis revealed that phorbol 12-myristate 13-acetate-induced Egr-1 in leiomyoma cells retained DNA binding ability.	Tetradecanoylphorbol Acetate	54-85	early growth response 1	Homo sapiens	94-99
15580810-4	2004	Phorbol-myristate-acetate (PMA)/ionomycin-stimulated SMC (splenic mononuclear cells) from mice fed with ATRA and the vitamin A-deficient diet group showed increased interleukin-4 (IL-4) responses in non-sensitized mice.	Tetradecanoylphorbol Acetate	0-25	interleukin 4	Mus musculus	165-178
15580810-4	2004	Phorbol-myristate-acetate (PMA)/ionomycin-stimulated SMC (splenic mononuclear cells) from mice fed with ATRA and the vitamin A-deficient diet group showed increased interleukin-4 (IL-4) responses in non-sensitized mice.	Tetradecanoylphorbol Acetate	0-25	interleukin 4	Mus musculus	180-184
15580810-4	2004	Phorbol-myristate-acetate (PMA)/ionomycin-stimulated SMC (splenic mononuclear cells) from mice fed with ATRA and the vitamin A-deficient diet group showed increased interleukin-4 (IL-4) responses in non-sensitized mice.	Tetradecanoylphorbol Acetate	27-30	interleukin 4	Mus musculus	165-178
16188211-9	2005	The treatment of LA-N-1 cells with 12-O-tetradecanoyl-phorbol-13 acetate (TPA) and RA increases diacylglycerol (DAG) levels indicating the stimulation of PLC activity.	Tetradecanoylphorbol Acetate	35-72	heparan sulfate proteoglycan 2	Homo sapiens	154-157
16188211-9	2005	The treatment of LA-N-1 cells with 12-O-tetradecanoyl-phorbol-13 acetate (TPA) and RA increases diacylglycerol (DAG) levels indicating the stimulation of PLC activity.	Tetradecanoylphorbol Acetate	74-77	heparan sulfate proteoglycan 2	Homo sapiens	154-157
15580810-4	2004	Phorbol-myristate-acetate (PMA)/ionomycin-stimulated SMC (splenic mononuclear cells) from mice fed with ATRA and the vitamin A-deficient diet group showed increased interleukin-4 (IL-4) responses in non-sensitized mice.	Tetradecanoylphorbol Acetate	27-30	interleukin 4	Mus musculus	180-184
31303127-8	2020	The increase (p <= 0.05) in protein expression of connexin-32 and 43 in LycT + DMBA/TPA group suggests improved inter cellular communication when compared to DMBA/TPA group.	Tetradecanoylphorbol Acetate	163-166	gap junction protein, beta 1	Mus musculus	50-61
33003440-2	2020	In this paper, we report that podoplanin is coordinately expressed with the CD44 standard (CD44s) and variant (CD44v) isoforms in vivo-in hyperplastic skin after a pro-inflammatory stimulus with 12-O-tetradecanoylphorbol-13-acetate (TPA)-and in vitro-in cell lines representative of different stages of mouse-skin chemical carcinogenesis, as well as in human squamous carcinoma cell (SCC) lines.	Tetradecanoylphorbol Acetate	195-231	podoplanin	Mus musculus	30-40
15324564-3	2004	The purpose of this study was to observe the relationship between the EGR1mRNA expression and cell differentiation during TPA-induced K562 cell differentiation.	Tetradecanoylphorbol Acetate	122-125	early growth response 1	Homo sapiens	70-74
15324564-21	2004	CONCLUSION: K562 cells could express EGR1mRNA during TPA-induced differentiation, which suggested that EGR1mRNA might participate in the process of K562 cells differentiating into monocyte/macrophages, and might play an important role in precipitating and maintaining cell differentiation for leukemic cells.	Tetradecanoylphorbol Acetate	53-56	early growth response 1	Homo sapiens	37-41
15324564-21	2004	CONCLUSION: K562 cells could express EGR1mRNA during TPA-induced differentiation, which suggested that EGR1mRNA might participate in the process of K562 cells differentiating into monocyte/macrophages, and might play an important role in precipitating and maintaining cell differentiation for leukemic cells.	Tetradecanoylphorbol Acetate	53-56	early growth response 1	Homo sapiens	103-107
33003440-2	2020	In this paper, we report that podoplanin is coordinately expressed with the CD44 standard (CD44s) and variant (CD44v) isoforms in vivo-in hyperplastic skin after a pro-inflammatory stimulus with 12-O-tetradecanoylphorbol-13-acetate (TPA)-and in vitro-in cell lines representative of different stages of mouse-skin chemical carcinogenesis, as well as in human squamous carcinoma cell (SCC) lines.	Tetradecanoylphorbol Acetate	233-236	podoplanin	Mus musculus	30-40
15067002-5	2004	When PLD1 or PLD2 was introduced into those cells by an adenoviral gene-transfer technique, both PLD1 and PLD2 were activated by TPA.	Tetradecanoylphorbol Acetate	129-132	phospholipase D2	Mus musculus	13-17
32413593-5	2020	To shed light on this, we employed synthetic polymer biointerfaces, poly(ethyl acrylate) (PEA) and poly(methyl acrylate) (PMA) coated with ECM proteins laminin or fibronectin (FN), to generate controlled microenvironments and investigate their effects on the cellular phenotype of primary fibroblasts harbouring a COL4A2+/G702D mutation.	Tetradecanoylphorbol Acetate	122-125	multimerin 1	Homo sapiens	139-142
15067002-5	2004	When PLD1 or PLD2 was introduced into those cells by an adenoviral gene-transfer technique, both PLD1 and PLD2 were activated by TPA.	Tetradecanoylphorbol Acetate	129-132	phospholipase D2	Mus musculus	106-110
15067002-8	2004	The effects of TPA on the down-regulation of basal or alpha-melanocyte-stimulating hormone-enhanced melanogenesis were almost completely blocked by expressing a lipase activity-negative mutant, LN-PLD2, but not by LN-PLD1.	Tetradecanoylphorbol Acetate	15-18	phospholipase D2	Mus musculus	197-201
15130280-2	2004	At all selected time points analyzed after TPA treatment, there was more MnSOD immunoreactive protein in mitochondria of keratinocytes of TgH mice than Ntg mice.	Tetradecanoylphorbol Acetate	43-46	carboxylesterase 1D	Mus musculus	138-141
32554052-4	2020	Eomes promoted the interaction of RelA and NFATc2 with the Ifng promoter and five CNS, including CNS-22 and CNS + 30 upon stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	139-170	eomesodermin	Mus musculus	0-5
15130280-4	2004	Indices of mitosis and apoptosis of keratinocytes were greater in DMBA/TPA-treated TgH than Ntg mouse skin.	Tetradecanoylphorbol Acetate	71-74	carboxylesterase 1D	Mus musculus	83-86
15033993-6	2004	Protonation of this group resulted in a significant increase in both k(lim) and K(0.5) and a 4.6-fold decrease in the specificity of the reaction of tPA with NBD P9 PAI-1.	Tetradecanoylphorbol Acetate	149-152	serpin family E member 1	Homo sapiens	165-170
15033993-9	2004	Since slightly acidic pH is a feature of a number of malignant tumors, alterations in PAI-1/tPA kinetics could play a role in the cancerogenesis.	Tetradecanoylphorbol Acetate	92-95	serpin family E member 1	Homo sapiens	86-91
32554052-4	2020	Eomes promoted the interaction of RelA and NFATc2 with the Ifng promoter and five CNS, including CNS-22 and CNS + 30 upon stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	139-170	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	34-38
14729583-4	2004	In another study, celecoxib attenuated the DNA binding activity of activator protein 1 (AP-1) through suppression of c-Jun and c-Fos expression in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	147-150	FBJ osteosarcoma oncogene	Mus musculus	127-132
32554052-4	2020	Eomes promoted the interaction of RelA and NFATc2 with the Ifng promoter and five CNS, including CNS-22 and CNS + 30 upon stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	172-175	eomesodermin	Mus musculus	0-5
32554052-4	2020	Eomes promoted the interaction of RelA and NFATc2 with the Ifng promoter and five CNS, including CNS-22 and CNS + 30 upon stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM).	Tetradecanoylphorbol Acetate	172-175	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	34-38
32973102-9	2020	However, cIMT and TPA were higher in both the CAD+ and O-CAD+ group compared with the CAD- or O-CAD- groups, respectively.	Tetradecanoylphorbol Acetate	18-21	aconitate decarboxylase 1	Homo sapiens	46-50
15038074-7	2004	On the other hand, protein kinase C and ADAM 9 protease are essential for the TPA-induced shedding.	Tetradecanoylphorbol Acetate	78-81	ADAM metallopeptidase domain 9	Homo sapiens	40-46
32973102-9	2020	However, cIMT and TPA were higher in both the CAD+ and O-CAD+ group compared with the CAD- or O-CAD- groups, respectively.	Tetradecanoylphorbol Acetate	18-21	aconitate decarboxylase 1	Homo sapiens	57-61
14699063-5	2004	Knockdown of either Rac1 or IQGAP1 accelerated the 12-O-tetradecanoylphorbol-13-acetate-induced cell-cell dissociation.	Tetradecanoylphorbol Acetate	51-87	IQ motif containing GTPase activating protein 1	Canis lupus familiaris	28-34
32814394-3	2020	Distinctly different from the previously reported PDI trimers with a TPA core, which exhibit amorphous morphologies, these hexapod-shaped acceptors display improved crystallinities and photophysical properties.	Tetradecanoylphorbol Acetate	69-72	peptidyl arginine deiminase 1	Homo sapiens	50-53
14565945-3	2004	Secretion of phosphatidylcholine, surfactant protein (SP)-B and SP-C was stimulated by terbutaline, 5"-N-ethylcarboxyamidoadenosine (NECA), ATP, UTP, TPA, and ionomycin.	Tetradecanoylphorbol Acetate	150-153	surfactant associated protein B	Mus musculus	34-59
32302668-8	2020	Both high glucose and non-specific activator of CatC phorbol 12-myristate 13-acetate (PMA) diminished nephrin, cofilin, and GLUT4 levels and induced cytoskeletal rearrangements, increasing albumin permeability in podocytes.	Tetradecanoylphorbol Acetate	53-84	cathepsin C	Rattus norvegicus	48-52
14605001-3	2004	A 5- to 9-fold and a 4- to 7-fold induction in NNT-1/BSF-3 mRNA expression was observed between 2 and 6 h stimulation with the protein kinase C (PKC) stimulus phorbol-12-myristate-13-acetate (100 nm) and the protein kinase A (PKA) stimulus Bu(2)cAMP (5 mm), respectively.	Tetradecanoylphorbol Acetate	159-190	cardiotrophin-like cytokine factor 1	Mus musculus	47-58
14728679-2	2004	It is produced from the 160-kDa mature LDL receptor by a proteolytic cleavage, which is stimulated in the presence of 4beta-phorbol 12-myristate 13-acetate (PMA), leading to the release of a soluble fragment that constitutes the bulk of the extracellular domain of the LDL receptor.	Tetradecanoylphorbol Acetate	118-155	low density lipoprotein receptor	Homo sapiens	39-51
14728679-2	2004	It is produced from the 160-kDa mature LDL receptor by a proteolytic cleavage, which is stimulated in the presence of 4beta-phorbol 12-myristate 13-acetate (PMA), leading to the release of a soluble fragment that constitutes the bulk of the extracellular domain of the LDL receptor.	Tetradecanoylphorbol Acetate	118-155	low density lipoprotein receptor	Homo sapiens	269-281
14728679-2	2004	It is produced from the 160-kDa mature LDL receptor by a proteolytic cleavage, which is stimulated in the presence of 4beta-phorbol 12-myristate 13-acetate (PMA), leading to the release of a soluble fragment that constitutes the bulk of the extracellular domain of the LDL receptor.	Tetradecanoylphorbol Acetate	157-160	low density lipoprotein receptor	Homo sapiens	39-51
32302668-8	2020	Both high glucose and non-specific activator of CatC phorbol 12-myristate 13-acetate (PMA) diminished nephrin, cofilin, and GLUT4 levels and induced cytoskeletal rearrangements, increasing albumin permeability in podocytes.	Tetradecanoylphorbol Acetate	53-84	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	102-109
32302668-8	2020	Both high glucose and non-specific activator of CatC phorbol 12-myristate 13-acetate (PMA) diminished nephrin, cofilin, and GLUT4 levels and induced cytoskeletal rearrangements, increasing albumin permeability in podocytes.	Tetradecanoylphorbol Acetate	53-84	solute carrier family 2 member 4	Rattus norvegicus	124-129
32302668-8	2020	Both high glucose and non-specific activator of CatC phorbol 12-myristate 13-acetate (PMA) diminished nephrin, cofilin, and GLUT4 levels and induced cytoskeletal rearrangements, increasing albumin permeability in podocytes.	Tetradecanoylphorbol Acetate	86-89	cathepsin C	Rattus norvegicus	48-52
14728679-2	2004	It is produced from the 160-kDa mature LDL receptor by a proteolytic cleavage, which is stimulated in the presence of 4beta-phorbol 12-myristate 13-acetate (PMA), leading to the release of a soluble fragment that constitutes the bulk of the extracellular domain of the LDL receptor.	Tetradecanoylphorbol Acetate	157-160	low density lipoprotein receptor	Homo sapiens	269-281
32302668-8	2020	Both high glucose and non-specific activator of CatC phorbol 12-myristate 13-acetate (PMA) diminished nephrin, cofilin, and GLUT4 levels and induced cytoskeletal rearrangements, increasing albumin permeability in podocytes.	Tetradecanoylphorbol Acetate	86-89	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	102-109
32302668-8	2020	Both high glucose and non-specific activator of CatC phorbol 12-myristate 13-acetate (PMA) diminished nephrin, cofilin, and GLUT4 levels and induced cytoskeletal rearrangements, increasing albumin permeability in podocytes.	Tetradecanoylphorbol Acetate	86-89	solute carrier family 2 member 4	Rattus norvegicus	124-129
32780686-0	2020	Role of E2F1/SPHK1 and HSP27 During Irradiation in a PMA-Induced Inflammatory Model.	Tetradecanoylphorbol Acetate	53-56	E2F transcription factor 1	Homo sapiens	8-12
32780686-0	2020	Role of E2F1/SPHK1 and HSP27 During Irradiation in a PMA-Induced Inflammatory Model.	Tetradecanoylphorbol Acetate	53-56	sphingosine kinase 1	Homo sapiens	13-18
32780686-6	2020	Results: A total of 6 TFs (e.g., E2F1) and 51 key DEGs (e.g., SPHK1) were identified after 625 nm PBM in PMA-stimulated HaCaT cells.	Tetradecanoylphorbol Acetate	105-108	sphingosine kinase 1	Homo sapiens	62-67
12816732-2	2004	Enhanced uPAR expression as well as stabilization of uPAR mRNA by transforming growth factor-beta and phorbol myristate acetate (PMA) shares a common mechanism involving phosphorylation and dephosphorylation of a uPAR mRNA-binding protein (uPAR mRNABp).	Tetradecanoylphorbol Acetate	102-127	plasminogen activator, urokinase receptor	Homo sapiens	53-57
12816732-2	2004	Enhanced uPAR expression as well as stabilization of uPAR mRNA by transforming growth factor-beta and phorbol myristate acetate (PMA) shares a common mechanism involving phosphorylation and dephosphorylation of a uPAR mRNA-binding protein (uPAR mRNABp).	Tetradecanoylphorbol Acetate	102-127	plasminogen activator, urokinase receptor	Homo sapiens	53-57
32780686-8	2020	E2F1 knockdown drastically decreased the SPHK1 expression level and increased the intracellular ROS, as well as the expression levels of inflammation-related proteins in PMA-induced HaCaT cells.	Tetradecanoylphorbol Acetate	170-173	E2F transcription factor 1	Homo sapiens	0-4
12816732-2	2004	Enhanced uPAR expression as well as stabilization of uPAR mRNA by transforming growth factor-beta and phorbol myristate acetate (PMA) shares a common mechanism involving phosphorylation and dephosphorylation of a uPAR mRNA-binding protein (uPAR mRNABp).	Tetradecanoylphorbol Acetate	102-127	plasminogen activator, urokinase receptor	Homo sapiens	53-57
12816732-2	2004	Enhanced uPAR expression as well as stabilization of uPAR mRNA by transforming growth factor-beta and phorbol myristate acetate (PMA) shares a common mechanism involving phosphorylation and dephosphorylation of a uPAR mRNA-binding protein (uPAR mRNABp).	Tetradecanoylphorbol Acetate	129-132	plasminogen activator, urokinase receptor	Homo sapiens	53-57
32626908-7	2020	Microglia in the group receiving 72 h of PMA stimulation displayed the highest percentage of cells arrested in G0/G1, the highest amount of senescence-associated expression of p53 and p21, and the most prominent secretion of TNF-alpha and IL-1beta.	Tetradecanoylphorbol Acetate	41-44	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	176-179
12816732-2	2004	Enhanced uPAR expression as well as stabilization of uPAR mRNA by transforming growth factor-beta and phorbol myristate acetate (PMA) shares a common mechanism involving phosphorylation and dephosphorylation of a uPAR mRNA-binding protein (uPAR mRNABp).	Tetradecanoylphorbol Acetate	129-132	plasminogen activator, urokinase receptor	Homo sapiens	53-57
12816732-2	2004	Enhanced uPAR expression as well as stabilization of uPAR mRNA by transforming growth factor-beta and phorbol myristate acetate (PMA) shares a common mechanism involving phosphorylation and dephosphorylation of a uPAR mRNA-binding protein (uPAR mRNABp).	Tetradecanoylphorbol Acetate	129-132	plasminogen activator, urokinase receptor	Homo sapiens	53-57
12816732-3	2004	PMA-induced tyrosine phosphorylation of the uPAR mRNABp inhibited the uPAR mRNA-uPAR mRNABp interaction, stabilized uPAR mRNA and enhanced uPAR protein expression.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase receptor	Homo sapiens	44-48
12816732-3	2004	PMA-induced tyrosine phosphorylation of the uPAR mRNABp inhibited the uPAR mRNA-uPAR mRNABp interaction, stabilized uPAR mRNA and enhanced uPAR protein expression.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase receptor	Homo sapiens	70-74
12816732-3	2004	PMA-induced tyrosine phosphorylation of the uPAR mRNABp inhibited the uPAR mRNA-uPAR mRNABp interaction, stabilized uPAR mRNA and enhanced uPAR protein expression.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase receptor	Homo sapiens	70-74
12816732-3	2004	PMA-induced tyrosine phosphorylation of the uPAR mRNABp inhibited the uPAR mRNA-uPAR mRNABp interaction, stabilized uPAR mRNA and enhanced uPAR protein expression.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase receptor	Homo sapiens	70-74
32376646-6	2020	Profound differences were found, including: 1) term pregnancy dNK have an increased degranulation response to K562 and PMA/ionomycin but lower capacity to respond to human CMV-infected cells; 2) term pregnancy dNK are not skewed toward recognition of HLA-C, as was previously shown for first trimester dNK; and 3) protein and gene expression profiles identified multiple differences between pNK, first trimester, and term pregnancy dNK, suggesting term pregnancy dNK are a distinct type of NK cells.	Tetradecanoylphorbol Acetate	119-122	deoxyribonucleoside kinase	Drosophila melanogaster	62-65
12816732-3	2004	PMA-induced tyrosine phosphorylation of the uPAR mRNABp inhibited the uPAR mRNA-uPAR mRNABp interaction, stabilized uPAR mRNA and enhanced uPAR protein expression.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase receptor	Homo sapiens	70-74
15630183-8	2004	Up regulation of ICAM-1, VCAM-1 cyclooxygenase-2 (COX-2), KC and MIP-2 by TPA were markedly reduced by pre-treatment with extract of perilla (PE) or RA.	Tetradecanoylphorbol Acetate	74-77	C-X-C motif chemokine ligand 2	Homo sapiens	65-70
14630700-3	2004	PMA induced the phosphorylation of IKKbeta and the subsequent degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	0-3	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	35-42
32376646-6	2020	Profound differences were found, including: 1) term pregnancy dNK have an increased degranulation response to K562 and PMA/ionomycin but lower capacity to respond to human CMV-infected cells; 2) term pregnancy dNK are not skewed toward recognition of HLA-C, as was previously shown for first trimester dNK; and 3) protein and gene expression profiles identified multiple differences between pNK, first trimester, and term pregnancy dNK, suggesting term pregnancy dNK are a distinct type of NK cells.	Tetradecanoylphorbol Acetate	119-122	deoxyribonucleoside kinase	Drosophila melanogaster	63-65
32037602-8	2020	Incubation with the ERK activator, phorbol 12-myristate 13-acetate (40 mumol/L), for 12 hours reversed the effects of HOXB5 inhibition on MDM2 expression, cell proliferation, and apoptosis in HCC cells.	Tetradecanoylphorbol Acetate	35-66	homeobox B5	Mus musculus	118-123
14729073-1	2003	The prolonged treatment with phorbol 12-myristate 13-acetate (PMA) of a human megakaryoblastic leukemia cell line, MEG-O1, induced increase of sphingosine kinase (SPHK) enzyme activity and SPHK1 protein expression as well as SPHK1 message.	Tetradecanoylphorbol Acetate	29-60	sphingosine kinase 1	Homo sapiens	143-161
32037602-8	2020	Incubation with the ERK activator, phorbol 12-myristate 13-acetate (40 mumol/L), for 12 hours reversed the effects of HOXB5 inhibition on MDM2 expression, cell proliferation, and apoptosis in HCC cells.	Tetradecanoylphorbol Acetate	35-66	transformed mouse 3T3 cell double minute 2	Mus musculus	138-142
14729073-1	2003	The prolonged treatment with phorbol 12-myristate 13-acetate (PMA) of a human megakaryoblastic leukemia cell line, MEG-O1, induced increase of sphingosine kinase (SPHK) enzyme activity and SPHK1 protein expression as well as SPHK1 message.	Tetradecanoylphorbol Acetate	29-60	sphingosine kinase 1	Homo sapiens	163-167
16049338-3	2005	tPA-/- mice suffered an early and a more severe acute disease characterized by incomplete recovery when compared to wild-type controls, with significantly higher CNS levels of plasminogen activator inhibitor-1.	Tetradecanoylphorbol Acetate	0-3	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	176-209
32241917-3	2020	On the basis of our previous observation that an activator of protein kinase C (PKC), phorbol 12-myristate 13-acetate (PMA), induces Prss14/epithin shedding, here we further investigated the intracellular signaling pathway involved in this process.	Tetradecanoylphorbol Acetate	86-117	ST14 transmembrane serine protease matriptase	Homo sapiens	133-139
15814901-3	2005	These observations were corroborated in MA-10 and mLTC-1 Leydig tumor cell lines, in which activation of PKC by phorbol-12-myristate-13-acetate (PMA, 10 nM) increased CREB phosphorylation and total StAR (tot-StAR) protein expression.	Tetradecanoylphorbol Acetate	112-143	steroidogenic acute regulatory protein	Mus musculus	198-202
15814901-3	2005	These observations were corroborated in MA-10 and mLTC-1 Leydig tumor cell lines, in which activation of PKC by phorbol-12-myristate-13-acetate (PMA, 10 nM) increased CREB phosphorylation and total StAR (tot-StAR) protein expression.	Tetradecanoylphorbol Acetate	112-143	steroidogenic acute regulatory protein	Mus musculus	208-212
14527959-7	2003	Pretreatment with the PKC delta-selective inhibitor rottlerin or transfection with an antisense PKC delta oligonucleotide inhibited PMA-induced cIAP-2 expression, whereas cotransfection with a PKC delta plasmid induced cIAP-2 promoter activity, which, taken together, identifies a role for PKC delta in cIAP-2 induction.	Tetradecanoylphorbol Acetate	132-135	baculoviral IAP repeat containing 3	Homo sapiens	144-150
14527959-7	2003	Pretreatment with the PKC delta-selective inhibitor rottlerin or transfection with an antisense PKC delta oligonucleotide inhibited PMA-induced cIAP-2 expression, whereas cotransfection with a PKC delta plasmid induced cIAP-2 promoter activity, which, taken together, identifies a role for PKC delta in cIAP-2 induction.	Tetradecanoylphorbol Acetate	132-135	baculoviral IAP repeat containing 3	Homo sapiens	219-225
14527959-7	2003	Pretreatment with the PKC delta-selective inhibitor rottlerin or transfection with an antisense PKC delta oligonucleotide inhibited PMA-induced cIAP-2 expression, whereas cotransfection with a PKC delta plasmid induced cIAP-2 promoter activity, which, taken together, identifies a role for PKC delta in cIAP-2 induction.	Tetradecanoylphorbol Acetate	132-135	baculoviral IAP repeat containing 3	Homo sapiens	219-225
14527959-8	2003	Treatment with the proteasome inhibitor, MG132 or inhibitors of NF-kappa B (e.g. PDTC and gliotoxin), decreased PMA-induced up-regulation of cIAP-2.	Tetradecanoylphorbol Acetate	112-115	baculoviral IAP repeat containing 3	Homo sapiens	141-147
32241917-3	2020	On the basis of our previous observation that an activator of protein kinase C (PKC), phorbol 12-myristate 13-acetate (PMA), induces Prss14/epithin shedding, here we further investigated the intracellular signaling pathway involved in this process.	Tetradecanoylphorbol Acetate	119-122	ST14 transmembrane serine protease matriptase	Homo sapiens	133-139
31982939-9	2020	In contrast, human neutrophils strongly responded to G-CSF stimulation resulting also in a higher response to PMA + G-CSF stimulation.	Tetradecanoylphorbol Acetate	110-113	colony stimulating factor 3	Homo sapiens	53-58
14654785-6	2003	Previously, tandem AP1 sites in the promoter were reported to be important for the serum and TPA inducibility of the vimentin gene.	Tetradecanoylphorbol Acetate	93-96	vimentin	Homo sapiens	117-125
14714562-5	2003	Phorbol 12-myristate 13-acetate (PMA), an activator of PKC, inhibited proliferation, elevated intracellular calcium concentration, decreased the expression of K10, and increased the expressions of INV, FIL, and TG.	Tetradecanoylphorbol Acetate	0-31	keratin 10	Homo sapiens	159-162
14714562-5	2003	Phorbol 12-myristate 13-acetate (PMA), an activator of PKC, inhibited proliferation, elevated intracellular calcium concentration, decreased the expression of K10, and increased the expressions of INV, FIL, and TG.	Tetradecanoylphorbol Acetate	0-31	filaggrin	Homo sapiens	202-205
14714562-5	2003	Phorbol 12-myristate 13-acetate (PMA), an activator of PKC, inhibited proliferation, elevated intracellular calcium concentration, decreased the expression of K10, and increased the expressions of INV, FIL, and TG.	Tetradecanoylphorbol Acetate	33-36	keratin 10	Homo sapiens	159-162
16180310-0	2005	Downregulation of protein phosphatase 2A activity in HeLa cells at the G2-mitosis transition and unscheduled reactivation induced by 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	133-170	protein phosphatase 2 phosphatase activator	Homo sapiens	26-40
16180310-0	2005	Downregulation of protein phosphatase 2A activity in HeLa cells at the G2-mitosis transition and unscheduled reactivation induced by 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	172-175	protein phosphatase 2 phosphatase activator	Homo sapiens	26-40
16180310-6	2005	Treatment of G2 cells with TPA (10(-7) M) caused a reactivation of the downregulated PP2A activity within 20 min, i.e. the same time frame within which TPA was shown earlier to block HeLa cells at the transition from G2 to mitosis [Kinzel et al., 1988.	Tetradecanoylphorbol Acetate	27-30	protein phosphatase 2 phosphatase activator	Homo sapiens	85-89
16180310-6	2005	Treatment of G2 cells with TPA (10(-7) M) caused a reactivation of the downregulated PP2A activity within 20 min, i.e. the same time frame within which TPA was shown earlier to block HeLa cells at the transition from G2 to mitosis [Kinzel et al., 1988.	Tetradecanoylphorbol Acetate	152-155	protein phosphatase 2 phosphatase activator	Homo sapiens	85-89
16180310-9	2005	Activation of PP2A was also induced by TPA in mitotic cells.	Tetradecanoylphorbol Acetate	39-42	protein phosphatase 2 phosphatase activator	Homo sapiens	14-18
16180310-10	2005	The low activity of PP2A in mitotic cells was accompanied by a strong reaction of mitotic PP2A C with anti-P-Tyr antibodies in Western blots, which was reversed by treatment of mitotic cells with TPA.	Tetradecanoylphorbol Acetate	196-199	protein phosphatase 2 phosphatase activator	Homo sapiens	20-24
16180310-10	2005	The low activity of PP2A in mitotic cells was accompanied by a strong reaction of mitotic PP2A C with anti-P-Tyr antibodies in Western blots, which was reversed by treatment of mitotic cells with TPA.	Tetradecanoylphorbol Acetate	196-199	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	90-96
16180310-12	2005	Unscheduled reactivation of PP2A induced by TPA in late G2 phase appears to inhibit the progress into mitosis.	Tetradecanoylphorbol Acetate	44-47	protein phosphatase 2 phosphatase activator	Homo sapiens	28-32
15861394-8	2005	Further, inhibition of the AP-1 transcriptional complex by [6]-Gingerol, or by the ectopic expression of JDP2, blocked TGF-beta1-induced EMT and conversely, stimulation of AP-1 by 12-O-tetradecanoylphorbol 13-acetate (TPA) substituted for EGF in the induction of EMT by TGF-beta1 in cells containing normal Ras.	Tetradecanoylphorbol Acetate	180-216	Jun dimerization protein 2	Homo sapiens	105-109
15861394-8	2005	Further, inhibition of the AP-1 transcriptional complex by [6]-Gingerol, or by the ectopic expression of JDP2, blocked TGF-beta1-induced EMT and conversely, stimulation of AP-1 by 12-O-tetradecanoylphorbol 13-acetate (TPA) substituted for EGF in the induction of EMT by TGF-beta1 in cells containing normal Ras.	Tetradecanoylphorbol Acetate	218-221	Jun dimerization protein 2	Homo sapiens	105-109
14714562-5	2003	Phorbol 12-myristate 13-acetate (PMA), an activator of PKC, inhibited proliferation, elevated intracellular calcium concentration, decreased the expression of K10, and increased the expressions of INV, FIL, and TG.	Tetradecanoylphorbol Acetate	33-36	filaggrin	Homo sapiens	202-205
31982939-9	2020	In contrast, human neutrophils strongly responded to G-CSF stimulation resulting also in a higher response to PMA + G-CSF stimulation.	Tetradecanoylphorbol Acetate	110-113	colony stimulating factor 3	Homo sapiens	116-121
31932824-3	2020	This study aimed to investigate the underlying mechanisms of ROS and IL-5 reduction with citrus flavonoid treatment in PMA/ionomycin-induced EL-4 cells.	Tetradecanoylphorbol Acetate	119-122	interleukin 5	Mus musculus	69-73
14623498-4	2003	Although astrocytes responded to ATP or phorbol ester (PMA) with increased cPLA2 phosphorylation and arachidonic acid release, ATP or PMA only caused a small increase in levels of PGE2.	Tetradecanoylphorbol Acetate	55-58	phospholipase A2 group IVA	Rattus norvegicus	75-80
15930517-8	2005	We also found that EPA inhibited 12-O-tetradecanoylphorbol-13-acetate- or tumor necrosis factor-alpha-induced MMP-1 expression in HDFs and UV-induced MMP-1 expression in HaCaT cells.	Tetradecanoylphorbol Acetate	33-69	matrix metallopeptidase 1	Homo sapiens	110-115
16101361-4	2005	RESULTS: In addition to the published observations (PMA induces hBD-2 and -4; TNF-alpha induces hBD-2 and -3), it was found that PMA can upregulate hBD-1 and hBD-3, whereas TNF-alpha can induce hBD-4.	Tetradecanoylphorbol Acetate	129-132	defensin beta 103B	Homo sapiens	158-163
15917220-4	2005	FBI-1 enhanced NF-kappaB-mediated transcription of E-selectin genes in HeLa cells upon phorbol 12-myristate 13-acetate stimulation and overcame gene repression by IkappaB alpha or IkappaB beta.	Tetradecanoylphorbol Acetate	87-118	selectin E	Homo sapiens	51-61
13679379-0	2003	Multiple cis-elements mediate the transcriptional activation of human fra-1 by 12-O-tetradecanoylphorbol-13-acetate in bronchial epithelial cells.	Tetradecanoylphorbol Acetate	79-115	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	70-75
31102272-7	2019	Further, the percentage of alpha-glucosidase and alpha-amylase inhibition rate of TPA-loaded NE was found to be 78.5 and 43.42%, respectively.	Tetradecanoylphorbol Acetate	82-85	sucrase isomaltase (alpha-glucosidase)	Mus musculus	27-44
13679379-2	2003	Here, we have investigated the transcriptional regulation of fra-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) in human bronchial epithelial (HBE) cells, which are the direct targets of inhaled toxins/carcinogens.	Tetradecanoylphorbol Acetate	70-106	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	61-66
13679379-2	2003	Here, we have investigated the transcriptional regulation of fra-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) in human bronchial epithelial (HBE) cells, which are the direct targets of inhaled toxins/carcinogens.	Tetradecanoylphorbol Acetate	108-111	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	61-66
16024603-5	2005	In response to the 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) mouse skin carcinogenesis protocol, K14-Pdcd4 mice showed significant reductions in papilloma formation, carcinoma incidence, and papilloma-to-carcinoma conversion frequency compared with wild-type mice.	Tetradecanoylphorbol Acetate	57-93	keratin 14	Mus musculus	136-139
15972968-6	2005	Within the Rab11a gene promoter, we identified a functional AP-1 binding element that exhibited elevated c-Fos binding activity after TPA treatment of keratinocytes.	Tetradecanoylphorbol Acetate	134-137	FBJ osteosarcoma oncogene	Mus musculus	105-110
14585504-5	2003	We show that Egr-1 binds to PSEN-P2, and that PSEN-P2 activity is increased threefold by overexpression of Egr-1, and by 12-O-tetradecanoylphorbol-13-acetate (TPA), which induces physiological Egr-1 levels.	Tetradecanoylphorbol Acetate	121-157	early growth response 1	Homo sapiens	13-18
31720442-4	2019	Topical application of DMBA+TPA increased oxidative stress as shown by significantly increased TBARS values and reduced glutathione contents, and glutathione-S-transferase, superoxide dismutase and catalase activities.	Tetradecanoylphorbol Acetate	28-31	hematopoietic prostaglandin D synthase	Mus musculus	146-171
14585504-5	2003	We show that Egr-1 binds to PSEN-P2, and that PSEN-P2 activity is increased threefold by overexpression of Egr-1, and by 12-O-tetradecanoylphorbol-13-acetate (TPA), which induces physiological Egr-1 levels.	Tetradecanoylphorbol Acetate	159-162	early growth response 1	Homo sapiens	13-18
14511379-5	2003	Treatment of both the unstimulated or PMA-stimulated macrophages with xyloside resulted in decreased uPA activity and Western blotting analysis revealed an almost complete absence of secreted uPA protein after xyloside treatment of either control- or PMA-treated cells.	Tetradecanoylphorbol Acetate	38-41	plasminogen activator, urokinase	Mus musculus	101-104
14511379-5	2003	Treatment of both the unstimulated or PMA-stimulated macrophages with xyloside resulted in decreased uPA activity and Western blotting analysis revealed an almost complete absence of secreted uPA protein after xyloside treatment of either control- or PMA-treated cells.	Tetradecanoylphorbol Acetate	38-41	plasminogen activator, urokinase	Mus musculus	192-195
15622522-6	2005	TPA induced loss of function concomitant with a dislocation of ZO-1 and occludin could be prevented by inhibition of MEK1 by PD98059.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 1	Homo sapiens	117-121
31539224-2	2019	Phorbol-12-myristate-13-acetate (PMA) loaded gold nanocages (Au NCs) was closed with DNA gate which could be recognized and opened by miRNA-21 in HeLa cell.	Tetradecanoylphorbol Acetate	0-31	microRNA 21	Homo sapiens	134-142
16113798-0	2005	A subpopulation of human B lymphocytes can express a functional Tissue Factor in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	93-118	coagulation factor III, tissue factor	Homo sapiens	64-77
15806162-0	2005	Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements.	Tetradecanoylphorbol Acetate	121-124	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	31-36
12898704-5	2003	Although PMA increased phosphorylation in all three major MAP kinase pathways (ERK, p38 MAP kinase, and JNK), only inhibition of the ERK pathway by the MEK/ERK inhibitor U0126 (0.1-10 microM) significantly reduced MMP-9 upregulation, even when treatment was delayed for 4 h after PMA exposure.	Tetradecanoylphorbol Acetate	9-12	mitogen-activated protein kinase 8	Rattus norvegicus	104-107
12865435-6	2003	Pretreatment of cells with a specific ROCK inhibitor, Y27632, not only abrogated MLC phosphorylation and membrane contraction, but also prevented PMA-induced activation of caspase-3 and subsequent cell death, indicating that ROCK-dependent myosin-mediated contraction elicits an upstream signal required for caspase-3 activation in PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	146-149	myosin heavy chain 14	Homo sapiens	240-246
12865435-6	2003	Pretreatment of cells with a specific ROCK inhibitor, Y27632, not only abrogated MLC phosphorylation and membrane contraction, but also prevented PMA-induced activation of caspase-3 and subsequent cell death, indicating that ROCK-dependent myosin-mediated contraction elicits an upstream signal required for caspase-3 activation in PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	332-335	myosin heavy chain 14	Homo sapiens	240-246
12865435-8	2003	In summary, these results revealed that, following PMA treatment, the upregulation of the RhoA/ROCK pathway contributes to a cellular context that switches-on myosin-mediated contraction, which provides a mechanism for triggering apoptotic induction mediated by caspase-8 and -10.	Tetradecanoylphorbol Acetate	51-54	myosin heavy chain 14	Homo sapiens	159-165
12807917-7	2003	Furthermore, Kv1.3 stimulation by Fas ligand was prevented by chronic stimulation of protein kinase C with 20 nm phorbol 12-myristate 13-acetate during Fas ligand treatment, which also blocks apoptosis.	Tetradecanoylphorbol Acetate	113-144	Fas ligand	Homo sapiens	34-44
15806162-4	2005	Our recent analysis of the FRA-1 promoter has shown a critical role for a TRE located at -318 in mediating the TPA-induced expression.	Tetradecanoylphorbol Acetate	111-114	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	27-32
15806162-6	2005	Here, we show that a 40-bp (-276/-237) segment, comprising a TCF binding site and the CArG box (collectively known as serum response element, SRE), and an ATF site, is also necessary for the FRA-1 induction by TPA and EGF.	Tetradecanoylphorbol Acetate	210-213	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	191-196
15806162-11	2005	RNAi-mediated knockdown of endogenous SRF, ELK1 and c-JUN protein expression significantly reduced TPA-stimulated FRA-1 promoter activity.	Tetradecanoylphorbol Acetate	99-102	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	114-119
31539224-2	2019	Phorbol-12-myristate-13-acetate (PMA) loaded gold nanocages (Au NCs) was closed with DNA gate which could be recognized and opened by miRNA-21 in HeLa cell.	Tetradecanoylphorbol Acetate	33-36	microRNA 21	Homo sapiens	134-142
15910736-4	2005	Expression experiments using mitogen-activated protein kinase phosphatase-1 or a dominant-negative mutant of the ternary complex factor Elk-1 revealed that the distal cluster of serum response elements is essential in the TPA-induced enhancement of Egr-1 promoter activity, encompassing two independent TPA-responsive elements.	Tetradecanoylphorbol Acetate	303-306	early growth response 1	Homo sapiens	249-254
12807917-7	2003	Furthermore, Kv1.3 stimulation by Fas ligand was prevented by chronic stimulation of protein kinase C with 20 nm phorbol 12-myristate 13-acetate during Fas ligand treatment, which also blocks apoptosis.	Tetradecanoylphorbol Acetate	113-144	Fas ligand	Homo sapiens	152-162
31339777-9	2019	A TRPA1 agonist, cinnamaldehyde, significantly inhibited phorbol 12-myristate 13-acetate-stimulated expression of IL-1beta and chemokine (C-C motif) ligand 2 in macrophages, which were attenuated by pretreatment with a TRPA1 antagonist, HC030031.	Tetradecanoylphorbol Acetate	57-88	interleukin 1 alpha	Mus musculus	114-122
12910377-7	2003	In vitro, terminal differentiation towards a megakaryocyte-like phenotype could be induced by phorbol myristate acetate (PMA), with typical morphological features, upregulation of platelet-specific and downregulation of erythroid antigens, going along with downregulation of c-myc.	Tetradecanoylphorbol Acetate	94-119	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	275-280
12910377-7	2003	In vitro, terminal differentiation towards a megakaryocyte-like phenotype could be induced by phorbol myristate acetate (PMA), with typical morphological features, upregulation of platelet-specific and downregulation of erythroid antigens, going along with downregulation of c-myc.	Tetradecanoylphorbol Acetate	121-124	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	275-280
15910736-5	2005	The CRE in the proximal Egr-1 promoter plays, if anything, only a marginal role in TPA-induced stimulus-transcription coupling of the Egr-1 gene.	Tetradecanoylphorbol Acetate	83-86	early growth response 1	Homo sapiens	24-29
15910736-5	2005	The CRE in the proximal Egr-1 promoter plays, if anything, only a marginal role in TPA-induced stimulus-transcription coupling of the Egr-1 gene.	Tetradecanoylphorbol Acetate	83-86	early growth response 1	Homo sapiens	134-139
15911072-9	2005	Furthermore, the activation of NPR-C receptor by C-ANP(4-23) and CNP inhibits the mitogen-activated protein kinase activity stimulated by endothelin-3, platelet-derived growth factor, phorbol-12 myristate 13-acetate, suggesting that NPR-C receptor might also be coupled to other signal transduction system or that there may be an interaction of the NPR-C receptor and some other signaling pathways.	Tetradecanoylphorbol Acetate	184-215	natriuretic peptide receptor 3	Homo sapiens	31-36
15911072-9	2005	Furthermore, the activation of NPR-C receptor by C-ANP(4-23) and CNP inhibits the mitogen-activated protein kinase activity stimulated by endothelin-3, platelet-derived growth factor, phorbol-12 myristate 13-acetate, suggesting that NPR-C receptor might also be coupled to other signal transduction system or that there may be an interaction of the NPR-C receptor and some other signaling pathways.	Tetradecanoylphorbol Acetate	184-215	natriuretic peptide receptor 3	Homo sapiens	233-238
15911072-9	2005	Furthermore, the activation of NPR-C receptor by C-ANP(4-23) and CNP inhibits the mitogen-activated protein kinase activity stimulated by endothelin-3, platelet-derived growth factor, phorbol-12 myristate 13-acetate, suggesting that NPR-C receptor might also be coupled to other signal transduction system or that there may be an interaction of the NPR-C receptor and some other signaling pathways.	Tetradecanoylphorbol Acetate	184-215	natriuretic peptide receptor 3	Homo sapiens	233-238
31401196-6	2019	FINDINGS: Both glutamate and the NMDAR co-agonist d-serine are rapidly released by neutrophils in response to bacterial and PMA-induced activation.	Tetradecanoylphorbol Acetate	124-127	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	33-38
15904490-5	2005	After 24 hours of PMA-induced monocyte differentiation, the mean fluorescence intensity of CD147 in differentiated THP-1 cells (289.61 +/- 31.63) was higher than that of the undifferentiated THP-1 cells (205.1 +/- 19.25).	Tetradecanoylphorbol Acetate	18-21	basigin (Ok blood group)	Homo sapiens	91-96
15634742-4	2005	Exposure of mCT12 cells to EGF, ATP, PMA, and DBHQ caused an increase in phosphorylation of p42/p44 (extracellular signal-regulated kinase; ERK1/2).	Tetradecanoylphorbol Acetate	37-40	solute carrier family 16 (monocarboxylic acid transporters), member 12	Mus musculus	12-17
12885907-8	2003	However, in endogenous chromatin immunoprecipitation (ChIP) assays with tetradecanoyl phorbol acetate-induced PEL cells, RAP proved to specifically associate with the C/EBPalpha promoter in vivo, but only in a C/EBPalpha-dependent manner, implying an in vivo piggyback interaction with DNA-bound C/EBPalpha.	Tetradecanoylphorbol Acetate	72-101	LDL receptor related protein associated protein 1	Homo sapiens	121-124
12730223-6	2003	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate stimulated PYK2 phosphorylation and MMP-13 production.	Tetradecanoylphorbol Acetate	37-68	protein tyrosine kinase 2 beta	Homo sapiens	80-84
15634742-5	2005	Pretreatment of mCT12 monolayers with an ERK kinase inhibitor (PD-98059; 30 microM) prevented phosphorylation of p42/p44 and significantly reduced EGF, ATP, and PMA-induced inhibition of amiloride-sensitive I(sc).	Tetradecanoylphorbol Acetate	161-164	solute carrier family 16 (monocarboxylic acid transporters), member 12	Mus musculus	16-21
15634742-6	2005	In contrast, pretreatment of monolayers with a PKC inhibitor (bisindolylmaleimide I; GF109203x; 1 microM) almost completely blocked the PMA-induced decrease in I(sc), but did not alter the EGF- or ATP-induced inhibition of I(sc).	Tetradecanoylphorbol Acetate	136-139	epidermal growth factor	Mus musculus	189-192
12807490-7	2003	We also examined the effect of phorbol 12-myristate 13-acetate (PMA) induction on 2B4 gene transcription.	Tetradecanoylphorbol Acetate	31-62	CD244 molecule	Homo sapiens	82-85
12807490-7	2003	We also examined the effect of phorbol 12-myristate 13-acetate (PMA) induction on 2B4 gene transcription.	Tetradecanoylphorbol Acetate	64-67	CD244 molecule	Homo sapiens	82-85
31390749-8	2019	This carnosine antioxidant activity was accompanied by the attenuation of the PMA-induced Akt phosphorylation, the down-regulation of TNF-alpha and IL-6 mRNAs, and the up-regulation of the expression of the anti-inflammatory mediators IL-4, IL-10, and TGF-beta1.	Tetradecanoylphorbol Acetate	78-81	interleukin 4	Mus musculus	235-239
15862172-7	2005	In response to high glucose or acute phorbol myristate acetate (PMA) stimulation, VEGF mRNA analysed by RT-PCR was increased.	Tetradecanoylphorbol Acetate	37-62	vascular endothelial growth factor A	Rattus norvegicus	82-86
15862172-7	2005	In response to high glucose or acute phorbol myristate acetate (PMA) stimulation, VEGF mRNA analysed by RT-PCR was increased.	Tetradecanoylphorbol Acetate	64-67	vascular endothelial growth factor A	Rattus norvegicus	82-86
15862172-12	2005	Secretion of VEGF in normal or high glucose, or hypoxia was significantly reduced following treatment with PMA for 24 hr but not with the PKC-zeta inhibitor.	Tetradecanoylphorbol Acetate	107-110	vascular endothelial growth factor A	Rattus norvegicus	13-17
31118064-16	2019	Small molecule compound 12-O-tetradecanoyl phorbol-13-acetate (TPA) treatment, which stimulated CYR61 expression, and verteporfin (VP) treatment, which inhibited CYR61 expression, confirmed that the enhancers regulated CYR61 expression.	Tetradecanoylphorbol Acetate	63-66	cellular communication network factor 1	Homo sapiens	96-101
15843042-2	2005	In the present study, we found that 12-o-tetradecanoylphorbol 13-acetate (TPA) induced cyclooxygenase 2 (COX-2), but not COX-1, protein expression in HL-60 cells, and the addition of arachidonic acid (AA) in the presence or absence of TPA significantly reduced the viability of HL-60 cells, an effect that was blocked by adding the COX inhibitors, NS398 and aspirin.	Tetradecanoylphorbol Acetate	74-77	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	121-126
15695813-5	2005	Moreover, incubation of cells with phorbol 12-myristate 13-acetate (PMA) stimulated phosphate incorporation into IQGAP1.	Tetradecanoylphorbol Acetate	35-66	IQ motif containing GTPase activating protein 1	Homo sapiens	113-119
12829841-10	2003	In tetradecanoyl phorbol acetate-treated PEL cells, loss of LANA expression correlated temporally with loss of detectable beta-catenin.	Tetradecanoylphorbol Acetate	3-32	catenin beta 1	Homo sapiens	122-134
14592552-3	2003	Collagen-stimulated platelet thromboxane B2 (TxB2) production and phorbol 12-myristate-13-acetate (PMA)-induced neutrophil prostaglandin E2 (PGE2) synthesis were used as indicators for COX-1 and COX-2 activity, respectively.	Tetradecanoylphorbol Acetate	99-102	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	185-190
15695813-5	2005	Moreover, incubation of cells with phorbol 12-myristate 13-acetate (PMA) stimulated phosphate incorporation into IQGAP1.	Tetradecanoylphorbol Acetate	68-71	IQ motif containing GTPase activating protein 1	Homo sapiens	113-119
30922783-1	2019	uPA/tPA-mediated activation of plasminogen/plasmin pathway during S. aureus arthritis facilitates the invasion of phagocytes in the affected joint, induces production of cytokines and triggers inflammatory pathways.	Tetradecanoylphorbol Acetate	4-7	plasminogen activator, urokinase	Mus musculus	0-3
15695813-6	2005	By using mass spectrometry, Ser-1443 was identified as the major site phosphorylated on IQGAP1 in intact cells treated with PMA.	Tetradecanoylphorbol Acetate	124-127	IQ motif containing GTPase activating protein 1	Homo sapiens	88-94
12739001-2	2003	When K562 cells were induced to differentiate into the megakaryocyte lineage by treatment with TPA, the expression of the c-ets-1, Fli-1 and TEL2 genes was increased, and that of the TEL gene was decreased at the onset of differentiation.	Tetradecanoylphorbol Acetate	95-98	ETS proto-oncogene 1, transcription factor	Homo sapiens	122-129
15735738-6	2005	Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-kappaB through suppression of IkappaBalpha degradation and p65 nuclear translocation.	Tetradecanoylphorbol Acetate	62-65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	182-185
30922783-2	2019	PAI-1, an effective inhibitor of both uPA and tPA, attenuates plasmin activity.	Tetradecanoylphorbol Acetate	46-49	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	0-5
15735738-8	2005	In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-kappaB.	Tetradecanoylphorbol Acetate	36-39	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	74-77
12745080-1	2003	In isolated rat pancreatic acini, protein expression of RhoA and Rho-associated kinase, ROCK-II, and the formation of immunocomplex of RhoA with ROCK-II were enhanced by CCK-8, carbachol, and the phorbol ester TPA.	Tetradecanoylphorbol Acetate	210-213	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	145-152
30219864-6	2019	Nonetheless, overexpression of WT-SMAD7 caused a susceptibility to 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperproliferation through activation of epidermal growth factor (EGF) signaling.	Tetradecanoylphorbol Acetate	67-103	epidermal growth factor	Mus musculus	163-186
12654926-3	2003	Transgenic keratinocytes had higher basal Erk activity and IL-1alpha levels than nontransgenic controls and were more sensitive to stimulation of Erk activity and IL-1alpha production by IL-1alpha, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), and serum.	Tetradecanoylphorbol Acetate	198-234	interleukin 1 alpha	Mus musculus	163-172
12654926-3	2003	Transgenic keratinocytes had higher basal Erk activity and IL-1alpha levels than nontransgenic controls and were more sensitive to stimulation of Erk activity and IL-1alpha production by IL-1alpha, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), and serum.	Tetradecanoylphorbol Acetate	198-234	interleukin 1 alpha	Mus musculus	163-172
12654926-3	2003	Transgenic keratinocytes had higher basal Erk activity and IL-1alpha levels than nontransgenic controls and were more sensitive to stimulation of Erk activity and IL-1alpha production by IL-1alpha, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), and serum.	Tetradecanoylphorbol Acetate	236-239	interleukin 1 alpha	Mus musculus	163-172
12654926-3	2003	Transgenic keratinocytes had higher basal Erk activity and IL-1alpha levels than nontransgenic controls and were more sensitive to stimulation of Erk activity and IL-1alpha production by IL-1alpha, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), and serum.	Tetradecanoylphorbol Acetate	236-239	interleukin 1 alpha	Mus musculus	163-172
15755660-5	2005	In particular, ceramide derivatives with a lauroyl group showed strong inhibitory activities on IL-4 production in both phorbol 12-myristate 13-acetate (PMA)-activated EL4 T cells and antigen-primed cells, suggesting that they can be used as compounds for the development of anti-allergic agents.	Tetradecanoylphorbol Acetate	120-151	interleukin 4	Mus musculus	96-100
15755660-5	2005	In particular, ceramide derivatives with a lauroyl group showed strong inhibitory activities on IL-4 production in both phorbol 12-myristate 13-acetate (PMA)-activated EL4 T cells and antigen-primed cells, suggesting that they can be used as compounds for the development of anti-allergic agents.	Tetradecanoylphorbol Acetate	153-156	interleukin 4	Mus musculus	96-100
15778356-4	2005	In contrast, IL-4-cultured NK cells produced significant levels of TNF-alpha and GM-CSF only when stimulated with PMA and ionomycin.	Tetradecanoylphorbol Acetate	114-117	colony stimulating factor 2	Homo sapiens	81-87
12654926-5	2003	TPA or IL-1alpha treatment resulted in rapid down-regulation of the EGF receptor in transgenic cells, indicative of transactivation.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor	Mus musculus	68-71
12654926-6	2003	Inhibition of transactivation blocked basal and TPA or IL-1alpha induced Erk activation, but not IkappaBalpha degradation, and abolished increased IL-1alpha production in transgenic cells.	Tetradecanoylphorbol Acetate	48-51	interleukin 1 alpha	Mus musculus	147-156
15710363-7	2005	In mammalian two-hybrid assays, treatment with phorbol 12-myristate 13-acetate (PMA) increased the strength of interaction between PXR and the nuclear receptor co-repressor protein (NCoR).	Tetradecanoylphorbol Acetate	47-78	nuclear receptor corepressor 1	Homo sapiens	143-180
30219864-6	2019	Nonetheless, overexpression of WT-SMAD7 caused a susceptibility to 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperproliferation through activation of epidermal growth factor (EGF) signaling.	Tetradecanoylphorbol Acetate	67-103	epidermal growth factor	Mus musculus	188-191
15710363-7	2005	In mammalian two-hybrid assays, treatment with phorbol 12-myristate 13-acetate (PMA) increased the strength of interaction between PXR and the nuclear receptor co-repressor protein (NCoR).	Tetradecanoylphorbol Acetate	47-78	nuclear receptor corepressor 1	Homo sapiens	182-186
15710363-7	2005	In mammalian two-hybrid assays, treatment with phorbol 12-myristate 13-acetate (PMA) increased the strength of interaction between PXR and the nuclear receptor co-repressor protein (NCoR).	Tetradecanoylphorbol Acetate	80-83	nuclear receptor corepressor 1	Homo sapiens	143-180
30905492-4	2019	METHODS: We evaluated the effect of topical S18-000003 on psoriasis-like skin inflammation and influence on the thymus in a 12-O-tetradecanoylphorbol-13-acetate-induced K14.Stat3C mouse psoriasis model.	Tetradecanoylphorbol Acetate	124-160	keratin 14	Mus musculus	169-172
15710363-7	2005	In mammalian two-hybrid assays, treatment with phorbol 12-myristate 13-acetate (PMA) increased the strength of interaction between PXR and the nuclear receptor co-repressor protein (NCoR).	Tetradecanoylphorbol Acetate	80-83	nuclear receptor corepressor 1	Homo sapiens	182-186
30395261-5	2019	TACE was identified as the protease responsible for phorbol 12-myristate 13-acetate (PMA)-induced VCAM-1 release in murine endothelial cells.	Tetradecanoylphorbol Acetate	52-83	vascular cell adhesion molecule 1	Mus musculus	98-104
15472905-9	2005	By comparison, spontaneous phenotypes are modest in uPA-deficient mice, probably because they still have active tPA.	Tetradecanoylphorbol Acetate	112-115	proline-rich acidic protein 1	Mus musculus	52-55
12771942-7	2003	Overexpression, by transient transfection, of both forms of REPS2/POB1 in prostate cancer cell lines, induced apoptosis within 48 h. At shorter time intervals after transfection, signalling towards a TPA response element luciferase reporter was found to be inhibited.	Tetradecanoylphorbol Acetate	200-203	RALBP1 associated Eps domain containing 2	Homo sapiens	60-65
12771942-7	2003	Overexpression, by transient transfection, of both forms of REPS2/POB1 in prostate cancer cell lines, induced apoptosis within 48 h. At shorter time intervals after transfection, signalling towards a TPA response element luciferase reporter was found to be inhibited.	Tetradecanoylphorbol Acetate	200-203	RALBP1 associated Eps domain containing 2	Homo sapiens	66-70
30395261-5	2019	TACE was identified as the protease responsible for phorbol 12-myristate 13-acetate (PMA)-induced VCAM-1 release in murine endothelial cells.	Tetradecanoylphorbol Acetate	85-88	vascular cell adhesion molecule 1	Mus musculus	98-104
15389577-10	2005	We conclude that PMA-induced membrane ruffling is caused via ARF6-Rac1 and ARF1 pathways operating in parallel and that PLD may be inhibitory.	Tetradecanoylphorbol Acetate	17-20	ADP ribosylation factor 6	Homo sapiens	61-65
30675247-7	2019	Furthermore, the results demonstrated that the phorbol-12-myristate-13-acetate-induced protein 1/induced myeloid leukemia cell differentiation protein Mcl-1 axis is involved in intrinsic apoptosis induced by pemetrexed.	Tetradecanoylphorbol Acetate	47-78	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	151-156
15634764-9	2005	SERT interaction with protein phosphatase 2A catalytic subunit and syntaxin 1A decreased after PD169316 or beta-PMA treatment of synaptosomes.	Tetradecanoylphorbol Acetate	107-115	syntaxin 1A	Homo sapiens	67-78
12706368-3	2003	However, tPA and TIMP-2 were greater in normal colon (P&lt;0.05, Mann-Whitney) e.g. PAI-1: tumour, median 14.9 (range 0.2-80.2) ng/mg total protein; normal, 2.1 (0.1-65.0).	Tetradecanoylphorbol Acetate	9-12	serpin family E member 1	Homo sapiens	84-89
12707358-10	2003	Substitution of these residues with phenylalanines attenuated COX-2 promoter activity and c-Src-dependent phosphorylation of IKKbeta induced by TNF-alpha or TPA.	Tetradecanoylphorbol Acetate	157-160	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	125-132
12694376-5	2003	Both wound-healing and Boyden migration assays showed that TPA treatment promoted neuronal migration of GT1 cells; however, cotreatment of TPA with safingol or rottlerin (a PKC delta-selective inhibitor) clearly blocked this TPA effect, indicating that both PKC alpha and PKC delta may be positive regulators of neuronal migration.	Tetradecanoylphorbol Acetate	139-142	beta-1,4-galactosyltransferase 1	Homo sapiens	104-107
12694376-7	2003	Among the PKC downstream signal molecules, p130Cas, a mediator of cell migration, and its kinase, focal adhesion kinase (FAK), increased following TPA treatment; phosphorylation of p130Cas was induced in a PKC alpha-dependent manner.	Tetradecanoylphorbol Acetate	147-150	BCAR1 scaffold protein, Cas family member	Homo sapiens	43-50
12694376-7	2003	Among the PKC downstream signal molecules, p130Cas, a mediator of cell migration, and its kinase, focal adhesion kinase (FAK), increased following TPA treatment; phosphorylation of p130Cas was induced in a PKC alpha-dependent manner.	Tetradecanoylphorbol Acetate	147-150	BCAR1 scaffold protein, Cas family member	Homo sapiens	181-188
15574370-11	2005	The binding of tPA and plasmin to S100A10 also protects against inhibition by physiological inhibitors, PAI-1 and alpha2-antiplasmin, respectively.	Tetradecanoylphorbol Acetate	15-18	serpin family E member 1	Homo sapiens	104-109
30579151-10	2019	In these patients, the tPA-ROTEM results depended on FII, FXII, plasminogen, alpha2-antiplasmin, PAI-1 and TAFI levels.	Tetradecanoylphorbol Acetate	23-26	serpin family E member 1	Homo sapiens	97-102
15780477-2	2005	Here we examined whether the plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2) mRNA, endogenous inhibitors of tPA and uPA, are induced in the DRG following sciatic nerve transection.	Tetradecanoylphorbol Acetate	119-122	serpin family E member 1	Homo sapiens	29-69
12670492-7	2003	Phorbol 12-myristate 13-acetate down-regulated the expression of both CYP2D25 and CYP27A1 as well as the 25-hydroxylase activity of the hepatocytes.	Tetradecanoylphorbol Acetate	0-31	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	70-77
12645577-10	2003	Substitution of these residues with phenylalanines abolished ICAM-1 promoter activity and c-Src-dependent phosphorylation of IKKbeta induced by TNF-alpha or TPA.	Tetradecanoylphorbol Acetate	157-160	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	125-132
12592382-7	2003	In addition, AP-1 DNA-binding assay using nonisotopic capillary electrophoresis and laser-induced fluorescence (CE/LIF) demonstrated that the AP-1-related DNA-binding activity was significantly induced by TPA and Saikosaponin a, which can be reduced by PD98059 pretreatment.	Tetradecanoylphorbol Acetate	205-208	LIF interleukin 6 family cytokine	Homo sapiens	115-118
15780477-2	2005	Here we examined whether the plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2) mRNA, endogenous inhibitors of tPA and uPA, are induced in the DRG following sciatic nerve transection.	Tetradecanoylphorbol Acetate	119-122	serpin family E member 1	Homo sapiens	71-76
15780477-2	2005	Here we examined whether the plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2) mRNA, endogenous inhibitors of tPA and uPA, are induced in the DRG following sciatic nerve transection.	Tetradecanoylphorbol Acetate	119-122	serpin family B member 2	Homo sapiens	81-86
15780477-8	2005	Co-expression of PAI-1, 2 with tPA and uPA in DRG neurons suggests that these inhibitors may act in an autocrine manner to modulate extracellular proteolytic activity after nerve injury.	Tetradecanoylphorbol Acetate	31-34	serpin family E member 1	Homo sapiens	17-22
12757776-7	2003	Luciferase activity consistently increased after stimulation of JEG-3 cells by phorbol 12-myristate 13-acetate indicating that NF1, NF-kappa B and egr-1/Sp1 binding sites are crucial in inducible TFPI-2 expression.	Tetradecanoylphorbol Acetate	79-110	early growth response 1	Homo sapiens	147-152
30522955-5	2019	Notably, the novel pseudotripeptides influenced inflammatory cytokine expression (IL-1beta, IL-18, and TNF-alpha) in Abeta25-35-, PMA-, and LPS-treated THP-1 cells.	Tetradecanoylphorbol Acetate	130-133	interleukin 1 alpha	Homo sapiens	82-90
16491951-4	2005	In this study, we reported that skin-specific overexpressed EC-SOD transgenic mice showed half the number of tumors compared with the nontransgenic mice in the dimethylbenzanthracene (DMBA)-initiated and a 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted two-stage skin carcinogenesis model.	Tetradecanoylphorbol Acetate	206-242	superoxide dismutase 3, extracellular	Mus musculus	60-66
16491951-4	2005	In this study, we reported that skin-specific overexpressed EC-SOD transgenic mice showed half the number of tumors compared with the nontransgenic mice in the dimethylbenzanthracene (DMBA)-initiated and a 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted two-stage skin carcinogenesis model.	Tetradecanoylphorbol Acetate	244-247	superoxide dismutase 3, extracellular	Mus musculus	60-66
16491951-7	2005	Overall, EC-SOD overexpression inhibited the TPA-induced cell proliferation and DNA damage, and reduced the subsequent formation of tumors.	Tetradecanoylphorbol Acetate	45-48	superoxide dismutase 3, extracellular	Mus musculus	9-15
16491951-8	2005	Our data suggest that EC-SOD plays a protective role in DMBA/TPA-induced skin carcinogenesis.	Tetradecanoylphorbol Acetate	61-64	superoxide dismutase 3, extracellular	Mus musculus	22-28
15541342-4	2004	IL-1alpha, IL-1beta, and TNF-alpha alone had minimal stimulating effects on HGF production in human dermal fibroblasts, but they strongly inhibited production of HGF induced by cholera toxin, 8-bromo-cAMP, EGF, and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	215-246	interleukin 1 alpha	Homo sapiens	0-9
12581266-1	2003	AIMS: To examine the predictive power of plasminogen activator inhibitor-1 (PAI-1) and the complexes it forms with tissue plasminogen activator (tPA-PAI-1) for the two major Type 1 diabetes (T1D) complications (coronary artery disease (CAD) and overt nephropathy) in the context of standard risk factors.	Tetradecanoylphorbol Acetate	145-148	serpin family E member 1	Homo sapiens	149-154
12581266-3	2003	PAI-1 and tPA-PAI-1 were determined using ELISA methodology.	Tetradecanoylphorbol Acetate	10-13	serpin family E member 1	Homo sapiens	14-19
30597502-0	2019	tPA Point Mutation at Autolysis Loop Enhances Resistance to PAI-1 Inhibition and Catalytic Activity.	Tetradecanoylphorbol Acetate	0-3	serpin family E member 1	Homo sapiens	60-65
12627665-10	2003	Another example was seen recently in the antiphospholipid syndrome, where antibodies against Annexin II, a receptor for tPA, were found to be higher than in healthy controls.	Tetradecanoylphorbol Acetate	120-123	annexin A2	Homo sapiens	93-103
12527890-4	2003	Currently, little is known about whether EGFR or its tyrosine kinase is necessary for TPA-induced AP-1 activation.	Tetradecanoylphorbol Acetate	86-89	epidermal growth factor receptor	Mus musculus	41-45
15744362-1	2004	In this study we examined whether microtubules and heat shock protein 90 (Hsp90) are involved in phorbol myristate acetate (PMA) and N-formyl-Met-Leu-Phe (fMLP)-induced oxidative burst in DMSO-differentiated HL-60 cells.	Tetradecanoylphorbol Acetate	97-122	heat shock protein 90 alpha family class A member 1	Homo sapiens	51-72
15744362-1	2004	In this study we examined whether microtubules and heat shock protein 90 (Hsp90) are involved in phorbol myristate acetate (PMA) and N-formyl-Met-Leu-Phe (fMLP)-induced oxidative burst in DMSO-differentiated HL-60 cells.	Tetradecanoylphorbol Acetate	97-122	heat shock protein 90 alpha family class A member 1	Homo sapiens	74-79
15744362-1	2004	In this study we examined whether microtubules and heat shock protein 90 (Hsp90) are involved in phorbol myristate acetate (PMA) and N-formyl-Met-Leu-Phe (fMLP)-induced oxidative burst in DMSO-differentiated HL-60 cells.	Tetradecanoylphorbol Acetate	124-127	heat shock protein 90 alpha family class A member 1	Homo sapiens	74-79
15599096-8	2004	Notably, the inflammation induced by 12-O-tetradecanoylphorbol 13-acetate was blocked by treatment with SR144528, a CB2-receptor antagonist.	Tetradecanoylphorbol Acetate	37-73	cannabinoid receptor 2	Homo sapiens	116-119
12527890-6	2003	We demonstrated that the TPA or epidermal growth factor (EGF) induced AP-1 activation in the B82L cells that express wild-type EGFR, but not in the B82 cell, whereas autophosphorylation at tyrosine(1173) of EGFR in B82L cells was only induced by EGF, but not TPA.	Tetradecanoylphorbol Acetate	25-28	epidermal growth factor receptor	Mus musculus	127-131
12527890-6	2003	We demonstrated that the TPA or epidermal growth factor (EGF) induced AP-1 activation in the B82L cells that express wild-type EGFR, but not in the B82 cell, whereas autophosphorylation at tyrosine(1173) of EGFR in B82L cells was only induced by EGF, but not TPA.	Tetradecanoylphorbol Acetate	25-28	epidermal growth factor receptor	Mus musculus	207-211
30597502-4	2019	To improve the proteolytic properties of tPA to enhance thrombolytic therapy, we designed a series of mutants in tPA serine protease domain (tPA-SPD) based on the crystal structure of tPA-SPD:plasminogen activators inhibitor-1 (PAI-1) complex that we determined recently.	Tetradecanoylphorbol Acetate	41-44	serpin family E member 1	Homo sapiens	184-226
12527890-7	2003	The expression of tyrosine kinase-deficient EGFR (mutation at Lys-721) (B82M721) resulted in deficiency of AP-1 induction in cellular response to EGF, while TPA treatment led to fully AP-1 activation.	Tetradecanoylphorbol Acetate	157-160	epidermal growth factor receptor	Mus musculus	44-48
15520189-6	2004	Expression levels of activator protein-1 family members (c-jun, junB, junD, and c-fos) and transforming growth factor (TGF)-alpha were significantly lower in TPA-treated Smad3(-/-) skin, cultured keratinocytes, and papillomas, as compared with Smad3(+/+) controls.	Tetradecanoylphorbol Acetate	158-161	jun B proto-oncogene	Mus musculus	64-68
15520189-6	2004	Expression levels of activator protein-1 family members (c-jun, junB, junD, and c-fos) and transforming growth factor (TGF)-alpha were significantly lower in TPA-treated Smad3(-/-) skin, cultured keratinocytes, and papillomas, as compared with Smad3(+/+) controls.	Tetradecanoylphorbol Acetate	158-161	jun D proto-oncogene	Mus musculus	70-74
12527890-9	2003	Based on these results, we conclude that TPA-induced AP-1 activation requires the basal level-EGFR protein, but not EGFR tyrosine kinase and EGFR autophosphorylation at tyrosine(1173), whereas both EGFR tyrosine kinase and EGFR autophosphorylation at Y(1173) play a critical role in EGF-induced AP-1 activation.	Tetradecanoylphorbol Acetate	41-44	epidermal growth factor receptor	Mus musculus	94-98
30597502-4	2019	To improve the proteolytic properties of tPA to enhance thrombolytic therapy, we designed a series of mutants in tPA serine protease domain (tPA-SPD) based on the crystal structure of tPA-SPD:plasminogen activators inhibitor-1 (PAI-1) complex that we determined recently.	Tetradecanoylphorbol Acetate	41-44	serpin family E member 1	Homo sapiens	228-233
15520189-6	2004	Expression levels of activator protein-1 family members (c-jun, junB, junD, and c-fos) and transforming growth factor (TGF)-alpha were significantly lower in TPA-treated Smad3(-/-) skin, cultured keratinocytes, and papillomas, as compared with Smad3(+/+) controls.	Tetradecanoylphorbol Acetate	158-161	FBJ osteosarcoma oncogene	Mus musculus	80-85
15520189-6	2004	Expression levels of activator protein-1 family members (c-jun, junB, junD, and c-fos) and transforming growth factor (TGF)-alpha were significantly lower in TPA-treated Smad3(-/-) skin, cultured keratinocytes, and papillomas, as compared with Smad3(+/+) controls.	Tetradecanoylphorbol Acetate	158-161	transforming growth factor alpha	Mus musculus	119-129
15666830-1	2004	We have previously reported that the protein kinase C ligand 12-O-tetradecanoyphorbol-13-acetate (TPA) inhibited the angiotensin II (AII) stimulated CYP11B2 gene expression in the adrenocortical H295R cell line.	Tetradecanoylphorbol Acetate	98-101	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	149-156
15479821-9	2004	Our present study demonstrates for the first time that either p38 or c-myc siRNA can efficiently inhibit TPA-induced EBV reactivation in GT38 cells, indicating that p38- and/or c-myc-associated signaling pathways may play critical roles in the disruption of EBV latency by TPA.	Tetradecanoylphorbol Acetate	105-108	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	177-182
30597502-4	2019	To improve the proteolytic properties of tPA to enhance thrombolytic therapy, we designed a series of mutants in tPA serine protease domain (tPA-SPD) based on the crystal structure of tPA-SPD:plasminogen activators inhibitor-1 (PAI-1) complex that we determined recently.	Tetradecanoylphorbol Acetate	113-116	serpin family E member 1	Homo sapiens	184-226
30597502-4	2019	To improve the proteolytic properties of tPA to enhance thrombolytic therapy, we designed a series of mutants in tPA serine protease domain (tPA-SPD) based on the crystal structure of tPA-SPD:plasminogen activators inhibitor-1 (PAI-1) complex that we determined recently.	Tetradecanoylphorbol Acetate	113-116	serpin family E member 1	Homo sapiens	228-233
30597502-5	2019	We found that the A146Y substitution in tPA-SPD(A146Y) enhanced resistance to PAI-1 inactivation by 30-fold compared with original tPA-SPD.	Tetradecanoylphorbol Acetate	40-43	serpin family E member 1	Homo sapiens	78-83
30597502-5	2019	We found that the A146Y substitution in tPA-SPD(A146Y) enhanced resistance to PAI-1 inactivation by 30-fold compared with original tPA-SPD.	Tetradecanoylphorbol Acetate	131-134	serpin family E member 1	Homo sapiens	78-83
30597502-10	2019	Together, our findings reveal novel functions of A146Y variant, which not only increases the catalytic efficiency of the enzyme, but also enhances resistance to PAI-1 inhibition, and demonstrating that tPA-SPD (A146Y) variant is a much improved agent for thrombolytic therapy.	Tetradecanoylphorbol Acetate	202-205	serpin family E member 1	Homo sapiens	161-166
15467463-4	2004	Various extra-cellular stimuli, including cytokines, growth factors, 12-O-tetradecanoyl-phorbol 13-acetate (TPA) and IFN, activate pathways which regulate Mcl-1 expression.	Tetradecanoylphorbol Acetate	69-106	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	155-160
12409308-0	2003	Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.	Tetradecanoylphorbol Acetate	24-55	insulin receptor substrate 1	Homo sapiens	114-142
30619121-6	2018	Non-synonymous mutations in the LCR-resident TPA (12-O-tetradecanoylphorbol 13-acetate)-response elements (TRE) had significantly decreased p97 promoter activation.	Tetradecanoylphorbol Acetate	45-48	melanotransferrin	Homo sapiens	140-143
12409308-0	2003	Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.	Tetradecanoylphorbol Acetate	24-55	insulin receptor substrate 1	Homo sapiens	144-148
12409308-0	2003	Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.	Tetradecanoylphorbol Acetate	57-60	insulin receptor substrate 1	Homo sapiens	114-142
12409308-0	2003	Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.	Tetradecanoylphorbol Acetate	57-60	insulin receptor substrate 1	Homo sapiens	144-148
15467463-4	2004	Various extra-cellular stimuli, including cytokines, growth factors, 12-O-tetradecanoyl-phorbol 13-acetate (TPA) and IFN, activate pathways which regulate Mcl-1 expression.	Tetradecanoylphorbol Acetate	108-111	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	155-160
15354318-3	2004	12-O-tetradecanoyl phorbol-13-acetate (TPA), a well-known tumor promoter on topical application depletes the reduced glutathione content (GSH) and down regulates the activities of its metabolizing enzyme, glutathione-S-transferase (GST) and the activities of antioxidant enzymes.	Tetradecanoylphorbol Acetate	0-37	hematopoietic prostaglandin D synthase	Mus musculus	205-230
15354318-3	2004	12-O-tetradecanoyl phorbol-13-acetate (TPA), a well-known tumor promoter on topical application depletes the reduced glutathione content (GSH) and down regulates the activities of its metabolizing enzyme, glutathione-S-transferase (GST) and the activities of antioxidant enzymes.	Tetradecanoylphorbol Acetate	0-37	hematopoietic prostaglandin D synthase	Mus musculus	232-235
15354318-3	2004	12-O-tetradecanoyl phorbol-13-acetate (TPA), a well-known tumor promoter on topical application depletes the reduced glutathione content (GSH) and down regulates the activities of its metabolizing enzyme, glutathione-S-transferase (GST) and the activities of antioxidant enzymes.	Tetradecanoylphorbol Acetate	39-42	hematopoietic prostaglandin D synthase	Mus musculus	205-230
14696965-5	2003	Treatment of the cells with phorbolmyristate acetate (PMA), a protein kinase C (PKC) activator, enhanced expression of the 2 major VEGF isoforms in the cultured dental follicle cells, whereas adding a specific PKC inhibitor prevented this.	Tetradecanoylphorbol Acetate	28-52	vascular endothelial growth factor A	Rattus norvegicus	131-135
14696965-5	2003	Treatment of the cells with phorbolmyristate acetate (PMA), a protein kinase C (PKC) activator, enhanced expression of the 2 major VEGF isoforms in the cultured dental follicle cells, whereas adding a specific PKC inhibitor prevented this.	Tetradecanoylphorbol Acetate	54-57	vascular endothelial growth factor A	Rattus norvegicus	131-135
15354318-3	2004	12-O-tetradecanoyl phorbol-13-acetate (TPA), a well-known tumor promoter on topical application depletes the reduced glutathione content (GSH) and down regulates the activities of its metabolizing enzyme, glutathione-S-transferase (GST) and the activities of antioxidant enzymes.	Tetradecanoylphorbol Acetate	39-42	hematopoietic prostaglandin D synthase	Mus musculus	232-235
30619121-6	2018	Non-synonymous mutations in the LCR-resident TPA (12-O-tetradecanoylphorbol 13-acetate)-response elements (TRE) had significantly decreased p97 promoter activation.	Tetradecanoylphorbol Acetate	50-86	melanotransferrin	Homo sapiens	140-143
14696965-6	2003	Treatment with PMA also increased the protein level of VEGF.	Tetradecanoylphorbol Acetate	15-18	vascular endothelial growth factor A	Rattus norvegicus	55-59
30321531-6	2018	KB-34 suppressed the expression of matrix metalloproteinase-7 (MMP-7) at both the mRNA and protein levels in TPA-stimulated CRC cells (HT-29 and SW620).	Tetradecanoylphorbol Acetate	109-112	matrix metallopeptidase 7	Homo sapiens	35-61
12479852-4	2003	Prolonged exposure to 8Br-cAMP increased the phorbol 12-myristate 13-acetate (TPA)-stimulated superoxide generation and CD14 expression that characterize the differentiation phenotype, which was blocked by MEK-1 inhibitor.	Tetradecanoylphorbol Acetate	45-76	mitogen-activated protein kinase kinase 1	Homo sapiens	206-211
12479852-4	2003	Prolonged exposure to 8Br-cAMP increased the phorbol 12-myristate 13-acetate (TPA)-stimulated superoxide generation and CD14 expression that characterize the differentiation phenotype, which was blocked by MEK-1 inhibitor.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase kinase 1	Homo sapiens	206-211
12472895-4	2002	TPA treatment induced relocalization of PKCalpha-EGFP to growth cones and cell-cell adhesion sites, PKCgamma-EGFP to the nucleus, and PKCdelta-EGFP to the membrane ruffle, respectively.	Tetradecanoylphorbol Acetate	0-3	protein kinase C gamma	Homo sapiens	100-108
15350745-2	2004	Anti-IFNg labelled a product of PMA-ionomycin stimulated sheep, koala and possum lymphocytes.	Tetradecanoylphorbol Acetate	32-35	interferon gamma	Ovis aries	5-9
15313406-3	2004	In the present study we examined the inhibitory effect of several chemopreventive agents on the tumor necrosis factor (TNF) alpha- or 12-O-tetradecanoylphorbol 13 acetate (TPA)-induced promoter activity of GSTP1-1, as demonstrated by transient transfection experiments in K562 and U937 leukemia cells.	Tetradecanoylphorbol Acetate	134-170	glutathione S-transferase pi 1	Homo sapiens	206-213
15313406-3	2004	In the present study we examined the inhibitory effect of several chemopreventive agents on the tumor necrosis factor (TNF) alpha- or 12-O-tetradecanoylphorbol 13 acetate (TPA)-induced promoter activity of GSTP1-1, as demonstrated by transient transfection experiments in K562 and U937 leukemia cells.	Tetradecanoylphorbol Acetate	172-175	glutathione S-transferase pi 1	Homo sapiens	206-213
30321531-6	2018	KB-34 suppressed the expression of matrix metalloproteinase-7 (MMP-7) at both the mRNA and protein levels in TPA-stimulated CRC cells (HT-29 and SW620).	Tetradecanoylphorbol Acetate	109-112	matrix metallopeptidase 7	Homo sapiens	63-68
30321531-7	2018	We also demonstrated that induced heme oxygenase-1 (HO-1) expression in CRC cells (HT-29 and SW620) and HO-1 is required for KB-34-mediated suppression of the expression of MMP-7 in TPA-stimulated HT-29 cells.	Tetradecanoylphorbol Acetate	182-185	matrix metallopeptidase 7	Homo sapiens	173-178
15302583-1	2004	Signal transduction pathway and a new function of TIS21/BTG2/PC3 were investigated in p53 null U937 cells; Expression of TIS21 by 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulation was mediated by PKC-delta activation, however, was strongly inhibited by cPKC isozymes.	Tetradecanoylphorbol Acetate	130-167	BTG anti-proliferation factor 2	Homo sapiens	50-55
30321531-11	2018	In conclusion, KB-34 inhibits the TPA-stimulated metastatic potential of HT-29 cells by induction of HO-1 and may be a promising anti-cancer agent in chemotherapeutic strategies for CRC.	Tetradecanoylphorbol Acetate	34-37	heme oxygenase 1	Homo sapiens	101-105
15302583-1	2004	Signal transduction pathway and a new function of TIS21/BTG2/PC3 were investigated in p53 null U937 cells; Expression of TIS21 by 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulation was mediated by PKC-delta activation, however, was strongly inhibited by cPKC isozymes.	Tetradecanoylphorbol Acetate	130-167	BTG anti-proliferation factor 2	Homo sapiens	56-60
12913399-8	2002	Tirofiban/TNK-tPA and abciximab/rPA caused decreases in platelet-leukocyte aggregates as well as in binding of specific antibodies to the platelet vitronectin receptor and P-selectin (p &lt; 0.05, respect.).	Tetradecanoylphorbol Acetate	14-17	selectin P	Homo sapiens	172-182
12913400-11	2002	tPA had no effect on platelet aggregation in alpha2-AP(+/+) mice, however platelet micro-aggregation in alpha2-AP(-/-) mice was markedly increased by the treatment with tPA.	Tetradecanoylphorbol Acetate	169-172	serine (or cysteine) peptidase inhibitor, clade F, member 2	Mus musculus	104-113
15302583-1	2004	Signal transduction pathway and a new function of TIS21/BTG2/PC3 were investigated in p53 null U937 cells; Expression of TIS21 by 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulation was mediated by PKC-delta activation, however, was strongly inhibited by cPKC isozymes.	Tetradecanoylphorbol Acetate	130-167	BTG anti-proliferation factor 2	Homo sapiens	121-126
30267894-4	2018	Recombinant purified HP1173 (rHP1173) was found to bind to THP-1 cells that were differentiated into macrophages via phorbol-12-myristate-13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	117-148	hypothetical protein	Helicobacter pylori 26695	21-27
15302583-1	2004	Signal transduction pathway and a new function of TIS21/BTG2/PC3 were investigated in p53 null U937 cells; Expression of TIS21 by 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulation was mediated by PKC-delta activation, however, was strongly inhibited by cPKC isozymes.	Tetradecanoylphorbol Acetate	169-172	BTG anti-proliferation factor 2	Homo sapiens	121-126
15302583-2	2004	When U937 cells were treated with TPA+Go6976, but not TPA+Go6850, the level of TIS21 mRNA was maintained over that of TPA alone.	Tetradecanoylphorbol Acetate	34-37	BTG anti-proliferation factor 2	Homo sapiens	79-84
15302583-3	2004	When analyzed by FACS, TPA-induced G2/M arrest was significantly inhibited by Go6850, but not by Go6976, suggesting the involvement of TIS21 and nPKC isozymes.	Tetradecanoylphorbol Acetate	23-26	BTG anti-proliferation factor 2	Homo sapiens	135-140
15302583-8	2004	In summary, TPA-induced TIS21 mRNA expression is mediated by PKC-delta, and TIS21 induces G2/M arrest and cell death by inhibiting cyclin B1-Cdc2 binding and the kinase activity through its binding to Cdc2.	Tetradecanoylphorbol Acetate	12-15	BTG anti-proliferation factor 2	Homo sapiens	24-29
15302583-8	2004	In summary, TPA-induced TIS21 mRNA expression is mediated by PKC-delta, and TIS21 induces G2/M arrest and cell death by inhibiting cyclin B1-Cdc2 binding and the kinase activity through its binding to Cdc2.	Tetradecanoylphorbol Acetate	12-15	cyclin B1	Homo sapiens	131-140
15302583-8	2004	In summary, TPA-induced TIS21 mRNA expression is mediated by PKC-delta, and TIS21 induces G2/M arrest and cell death by inhibiting cyclin B1-Cdc2 binding and the kinase activity through its binding to Cdc2.	Tetradecanoylphorbol Acetate	12-15	cyclin dependent kinase 1	Homo sapiens	141-145
15302583-8	2004	In summary, TPA-induced TIS21 mRNA expression is mediated by PKC-delta, and TIS21 induces G2/M arrest and cell death by inhibiting cyclin B1-Cdc2 binding and the kinase activity through its binding to Cdc2.	Tetradecanoylphorbol Acetate	12-15	cyclin dependent kinase 1	Homo sapiens	201-205
12913400-12	2002	Moreover, the amount of released ATP from stimulated platelets was increased in alpha2-AP(-/-) mice treated with tPA.	Tetradecanoylphorbol Acetate	113-116	serine (or cysteine) peptidase inhibitor, clade F, member 2	Mus musculus	80-89
12244094-3	2002	Maximal binding of the Raf kinase domain to MEK1 and its kinase activity are achieved upon phosphorylation of the region (338)SSYY(341) in response to 4beta-12-O-tetradecanoylphorbol-13-acetate (TPA), or mutation of Y340Y341 to aspartic acids.	Tetradecanoylphorbol Acetate	195-198	mitogen-activated protein kinase kinase 1	Homo sapiens	44-48
12244094-7	2002	Separately, the binding of each site to MEK1 is weak, but in a cis context, they give rise to a much stronger association, which can be further stimulated by TPA.	Tetradecanoylphorbol Acetate	158-161	mitogen-activated protein kinase kinase 1	Homo sapiens	40-44
12223472-1	2002	We have delineated two different reaction mechanisms of monoclonal antibodies (mAbs), MA-8H9D4 and either MA-55F4C12 or MA-33H1F7, that convert plasminogen activator inhibitor 1 (PAI-1) to a substrate for tissue (tPA)- and urokinase plasminogen activators.	Tetradecanoylphorbol Acetate	213-216	serpin family E member 1	Homo sapiens	144-177
12223472-1	2002	We have delineated two different reaction mechanisms of monoclonal antibodies (mAbs), MA-8H9D4 and either MA-55F4C12 or MA-33H1F7, that convert plasminogen activator inhibitor 1 (PAI-1) to a substrate for tissue (tPA)- and urokinase plasminogen activators.	Tetradecanoylphorbol Acetate	213-216	serpin family E member 1	Homo sapiens	179-184
15666577-8	2004	Pretreatment of islets with phorbol 12-myristate 13-acetate (PMA) did not suggest any involvement of protein kinase C. In summary, a high concentration of leptin stimulates insulin release in the presence of stimulatory concentrations of glucose alone and with parasympathetic neurotransmitters.	Tetradecanoylphorbol Acetate	28-59	leptin	Mus musculus	155-161
15666577-8	2004	Pretreatment of islets with phorbol 12-myristate 13-acetate (PMA) did not suggest any involvement of protein kinase C. In summary, a high concentration of leptin stimulates insulin release in the presence of stimulatory concentrations of glucose alone and with parasympathetic neurotransmitters.	Tetradecanoylphorbol Acetate	61-64	leptin	Mus musculus	155-161
15178807-13	2004	These data also imply that Tsc2 expression modulates TPA-induced changes in renal epithelial cell morphology via an ERK-independent mechanism.	Tetradecanoylphorbol Acetate	53-56	TSC complex subunit 2	Rattus norvegicus	27-31
30267894-4	2018	Recombinant purified HP1173 (rHP1173) was found to bind to THP-1 cells that were differentiated into macrophages via phorbol-12-myristate-13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	150-153	hypothetical protein	Helicobacter pylori 26695	21-27
30404828-6	2018	alpha-Synuclein and phorbol 12-myristate 13-acetate (PMA), which is known to enhance vesicle priming mediated by Rab3A, Munc13-1 and Munc18-1, act on the same population of vesicles, but regulate priming independently.	Tetradecanoylphorbol Acetate	20-51	unc-13 homolog A	Rattus norvegicus	120-128
15178693-4	2004	L-selectin mutants defective for ERM binding show reduced localization to microvilli and decreased phorbol 12-myristate 13-acetate-induced shedding of the L-selectin ectodomain.	Tetradecanoylphorbol Acetate	99-130	selectin L	Homo sapiens	0-10
15178693-4	2004	L-selectin mutants defective for ERM binding show reduced localization to microvilli and decreased phorbol 12-myristate 13-acetate-induced shedding of the L-selectin ectodomain.	Tetradecanoylphorbol Acetate	99-130	selectin L	Homo sapiens	155-165
12482394-3	2002	The cytochrome c-sensitive TCR-expressing hybridoma (2B4) was stimulated with pigeon cytochrome c antigen, anti-CD3 crosslinking, or PMA and ionomycin, in the presence or absence of CP, and the resulting IL-2 produced was measured in a bioassay using an IL-2-dependent cell line (CTLL-2).	Tetradecanoylphorbol Acetate	133-136	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	27-30
30404828-6	2018	alpha-Synuclein and phorbol 12-myristate 13-acetate (PMA), which is known to enhance vesicle priming mediated by Rab3A, Munc13-1 and Munc18-1, act on the same population of vesicles, but regulate priming independently.	Tetradecanoylphorbol Acetate	20-51	syntaxin binding protein 1	Rattus norvegicus	133-141
30404828-6	2018	alpha-Synuclein and phorbol 12-myristate 13-acetate (PMA), which is known to enhance vesicle priming mediated by Rab3A, Munc13-1 and Munc18-1, act on the same population of vesicles, but regulate priming independently.	Tetradecanoylphorbol Acetate	53-56	unc-13 homolog A	Rattus norvegicus	120-128
30404828-6	2018	alpha-Synuclein and phorbol 12-myristate 13-acetate (PMA), which is known to enhance vesicle priming mediated by Rab3A, Munc13-1 and Munc18-1, act on the same population of vesicles, but regulate priming independently.	Tetradecanoylphorbol Acetate	53-56	syntaxin binding protein 1	Rattus norvegicus	133-141
12149272-7	2002	However, the addition of cytoplasmic extracts from adipocytes treated with 12-O-tetradecanoylphorbol-13-acetate or PKC alpha antisense oligomers inhibited LPL translation in vitro.	Tetradecanoylphorbol Acetate	75-111	lipoprotein lipase	Homo sapiens	155-158
30093697-3	2018	The goal of this study was to investigate the effect of TPA-023 in mice after acute or subchronic (sc) treatment with the N-methyl-D-aspartate receptor (NMDAR) antagonist, phencyclidine (PCP), on novel object recognition (NOR), reversal learning (RL), and locomotor activity (LMA) in rodents.	Tetradecanoylphorbol Acetate	56-59	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	122-151
12388770-9	2002	Antigen or phorbol 12-myristate 13-acetate stimulation increased both PLD1 and PLD2 activity when expressed individually in RBL-2H3 cells.	Tetradecanoylphorbol Acetate	11-42	phospholipase D2	Rattus norvegicus	79-83
29923144-6	2018	RESULTS: We found that treatment of HT-29 and Caco-2 cells (differentiated and low metastatic) with 12-O-tetradecanoyl phorbol-13-acetate (TPA; a tumor promoter) suppressed E-cadherin and beta-catenin expression at both the mRNA and protein levels and, in addition, enhanced cell migration.	Tetradecanoylphorbol Acetate	100-137	catenin beta 1	Homo sapiens	188-200
12091391-5	2002	When expression of c-myc was reduced in human promyelocytic leukemia HL60 cells by phorbol 12-myristate 13-acetate, the expression of mina53 mRNA and protein was reduced.	Tetradecanoylphorbol Acetate	83-114	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	19-24
12091391-5	2002	When expression of c-myc was reduced in human promyelocytic leukemia HL60 cells by phorbol 12-myristate 13-acetate, the expression of mina53 mRNA and protein was reduced.	Tetradecanoylphorbol Acetate	83-114	ribosomal oxygenase 2	Homo sapiens	134-140
29923144-6	2018	RESULTS: We found that treatment of HT-29 and Caco-2 cells (differentiated and low metastatic) with 12-O-tetradecanoyl phorbol-13-acetate (TPA; a tumor promoter) suppressed E-cadherin and beta-catenin expression at both the mRNA and protein levels and, in addition, enhanced cell migration.	Tetradecanoylphorbol Acetate	139-142	catenin beta 1	Homo sapiens	188-200
12124383-7	2002	PMA induced translocation of both endogenous and green fluorescent protein (GFP)-tagged human SK1 (hSK1) to the plasma membrane.	Tetradecanoylphorbol Acetate	0-3	sphingosine kinase 1	Homo sapiens	94-97
29923144-8	2018	We also found that TPA or hydrogen peroxide induced CTNNB1 gene promoter methylation to a higher extent in HT-29 and CCD-841 cells than in HCT-116 and SW620 cells, and that the degree of CTNNB1 gene promoter methylation positively correlated with cell dissociation and migration.	Tetradecanoylphorbol Acetate	19-22	catenin beta 1	Homo sapiens	52-58
12124383-7	2002	PMA induced translocation of both endogenous and green fluorescent protein (GFP)-tagged human SK1 (hSK1) to the plasma membrane.	Tetradecanoylphorbol Acetate	0-3	sphingosine kinase 1	Homo sapiens	99-103
29923144-8	2018	We also found that TPA or hydrogen peroxide induced CTNNB1 gene promoter methylation to a higher extent in HT-29 and CCD-841 cells than in HCT-116 and SW620 cells, and that the degree of CTNNB1 gene promoter methylation positively correlated with cell dissociation and migration.	Tetradecanoylphorbol Acetate	19-22	catenin beta 1	Homo sapiens	187-193
12124383-8	2002	PMA also induced phosphorylation of GFP-hSK1.	Tetradecanoylphorbol Acetate	0-3	sphingosine kinase 1	Homo sapiens	40-44
30596378-8	2018	CCL2 was detected in few cluster of differentiation (CD)14+ monocytes in PBMC stimulated with PMA and ionomycin for 2 h. CCL3 was produced by CD14+ monocytes after 4-6 h culture in medium.	Tetradecanoylphorbol Acetate	94-97	C-C motif chemokine 3	Equus caballus	121-125
12183516-5	2002	Examination of the ability of splenocytes from uninfected and infected mice to produce IFN-gamma revealed that IL-2(-/-) mice were hyporesponsive to stimulation with anti-CD3 or parasite antigen compared with wild-type mice, and the addition of IL-2 alone or in combination with IL-12 or stimulation with phorbol myristate acetate and ionomycin did not restore the production of IFN-gamma.	Tetradecanoylphorbol Acetate	305-330	interleukin 2	Mus musculus	111-115
30596378-9	2018	After stimulation with PMA and ionomycin for 12-24 h, CCL3 was also expressed in lymphocytes, mainly in CD4+ T cells.	Tetradecanoylphorbol Acetate	23-26	C-C motif chemokine 3	Equus caballus	54-58
29559340-0	2018	Epidermal FABP Prevents Chemical-Induced Skin Tumorigenesis by Regulation of TPA-Induced IFN/p53/SOX2 Pathway in Keratinocytes.	Tetradecanoylphorbol Acetate	77-80	transformation related protein 53, pseudogene	Mus musculus	93-96
12213882-8	2002	12-O-tetradecanoyl phorbol-13-acetate (protein kinase C activator) stimulated both activin A and inhibin A secretion (764- and 32-fold of control, respectively), and activin treatment increased inhibin B secretion in these cells (25-fold of control).	Tetradecanoylphorbol Acetate	0-37	inhibin subunit beta E	Homo sapiens	83-90
30301597-2	2018	Previously, we reported that irradiation with 200 mJ/cm2 of 310 nm NB-UVB suppressed phorbol-12-myristate-13-acetate (PMA)-induced up-regulation of histamine H1 receptor (H1R) gene expression without induction of apoptosis in HeLa cells.	Tetradecanoylphorbol Acetate	85-116	histamine receptor H1	Homo sapiens	148-169
12205183-7	2002	Several chemically distinct activators of PKC, such as phorbol-12-myristate-13-acetate (PMA), (-)indolactam V and 1,2,-dioctanoyl-sn-glycerol (DOG) inhibited the light response of voltage-clamped microvillar photoreceptors, but were ineffective in ciliary photoreceptors, in which light does not activate the G(q)/PLC cascade, nor elevates intracellular Ca2+.	Tetradecanoylphorbol Acetate	55-86	Protein C kinase 53E	Drosophila melanogaster	42-45
12205183-7	2002	Several chemically distinct activators of PKC, such as phorbol-12-myristate-13-acetate (PMA), (-)indolactam V and 1,2,-dioctanoyl-sn-glycerol (DOG) inhibited the light response of voltage-clamped microvillar photoreceptors, but were ineffective in ciliary photoreceptors, in which light does not activate the G(q)/PLC cascade, nor elevates intracellular Ca2+.	Tetradecanoylphorbol Acetate	88-91	Protein C kinase 53E	Drosophila melanogaster	42-45
12165498-2	2002	This study shows that CD62L acquired E-selectin-binding activity following phorbol ester (PMA) treatment of the Jurkat T cell line and anti-CD3/IL-2-driven proliferation of human T lymphocytes in vitro.	Tetradecanoylphorbol Acetate	90-93	selectin L	Homo sapiens	22-27
12165498-2	2002	This study shows that CD62L acquired E-selectin-binding activity following phorbol ester (PMA) treatment of the Jurkat T cell line and anti-CD3/IL-2-driven proliferation of human T lymphocytes in vitro.	Tetradecanoylphorbol Acetate	90-93	selectin E	Homo sapiens	37-47
30301597-2	2018	Previously, we reported that irradiation with 200 mJ/cm2 of 310 nm NB-UVB suppressed phorbol-12-myristate-13-acetate (PMA)-induced up-regulation of histamine H1 receptor (H1R) gene expression without induction of apoptosis in HeLa cells.	Tetradecanoylphorbol Acetate	85-116	histamine receptor H1	Homo sapiens	171-174
30301597-2	2018	Previously, we reported that irradiation with 200 mJ/cm2 of 310 nm NB-UVB suppressed phorbol-12-myristate-13-acetate (PMA)-induced up-regulation of histamine H1 receptor (H1R) gene expression without induction of apoptosis in HeLa cells.	Tetradecanoylphorbol Acetate	118-121	histamine receptor H1	Homo sapiens	148-169
30301597-2	2018	Previously, we reported that irradiation with 200 mJ/cm2 of 310 nm NB-UVB suppressed phorbol-12-myristate-13-acetate (PMA)-induced up-regulation of histamine H1 receptor (H1R) gene expression without induction of apoptosis in HeLa cells.	Tetradecanoylphorbol Acetate	118-121	histamine receptor H1	Homo sapiens	171-174
30073169-10	2018	In agreement, 80 nM PMA (a PKC activator) mimicked the effect of LPS on the activation of the MEK/ERK/TSC2/mTORC1/S6K pathway, monocyte adhesion to ECV cells and actin cytoskeleton rearrangement.	Tetradecanoylphorbol Acetate	20-23	ribosomal protein S6 kinase B1	Homo sapiens	114-117
12165498-3	2002	The recombinant porcine E-selectin/human Ig chimera P11.4 showed neuraminidase-sensitive and calcium-dependent attachment to PMA-stimulated human Jurkat T cells in a flow cytometry assay.	Tetradecanoylphorbol Acetate	125-128	selectin E	Homo sapiens	24-34
12114186-6	2002	Secretion of SP-B, SP-C, and phosphatidylcholine was stimulated by phorbol 12-myristate 13-acetate and was inhibited by compound 48/80.	Tetradecanoylphorbol Acetate	67-98	surfactant associated protein B	Mus musculus	13-17
29601810-10	2018	On the contrary, phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of Src, AKT, P38, PKC and membrane localization of p47ph x and P40ph x remained unaffected.	Tetradecanoylphorbol Acetate	17-48	pleckstrin	Homo sapiens	130-133
12130520-7	2002	Conversely, TPA treatment of RhAG-transfected cells increased both the transcript and surface expression levels of RhAG.	Tetradecanoylphorbol Acetate	12-15	Rh associated glycoprotein	Homo sapiens	29-33
12130520-7	2002	Conversely, TPA treatment of RhAG-transfected cells increased both the transcript and surface expression levels of RhAG.	Tetradecanoylphorbol Acetate	12-15	Rh associated glycoprotein	Homo sapiens	115-119
12130520-8	2002	When K562/RhD cells were cotransfected by the RhAG cDNA, the TPA-mediated induction of recombinant RhAG and RhD transcription was associated with an increased membrane expression of both RhAG and RhD proteins.	Tetradecanoylphorbol Acetate	61-64	Rh blood group D antigen	Homo sapiens	10-13
12130520-8	2002	When K562/RhD cells were cotransfected by the RhAG cDNA, the TPA-mediated induction of recombinant RhAG and RhD transcription was associated with an increased membrane expression of both RhAG and RhD proteins.	Tetradecanoylphorbol Acetate	61-64	Rh associated glycoprotein	Homo sapiens	46-50
29601810-10	2018	On the contrary, phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of Src, AKT, P38, PKC and membrane localization of p47ph x and P40ph x remained unaffected.	Tetradecanoylphorbol Acetate	50-53	pleckstrin	Homo sapiens	130-133
12130520-8	2002	When K562/RhD cells were cotransfected by the RhAG cDNA, the TPA-mediated induction of recombinant RhAG and RhD transcription was associated with an increased membrane expression of both RhAG and RhD proteins.	Tetradecanoylphorbol Acetate	61-64	Rh associated glycoprotein	Homo sapiens	99-103
12130520-8	2002	When K562/RhD cells were cotransfected by the RhAG cDNA, the TPA-mediated induction of recombinant RhAG and RhD transcription was associated with an increased membrane expression of both RhAG and RhD proteins.	Tetradecanoylphorbol Acetate	61-64	Rh blood group D antigen	Homo sapiens	108-111
29693192-8	2018	In addition, p53 expression levels were increased by SR in the DMBA/TPA-induced mice.	Tetradecanoylphorbol Acetate	68-71	transformation related protein 53, pseudogene	Mus musculus	13-16
12130520-8	2002	When K562/RhD cells were cotransfected by the RhAG cDNA, the TPA-mediated induction of recombinant RhAG and RhD transcription was associated with an increased membrane expression of both RhAG and RhD proteins.	Tetradecanoylphorbol Acetate	61-64	Rh associated glycoprotein	Homo sapiens	99-103
12130520-8	2002	When K562/RhD cells were cotransfected by the RhAG cDNA, the TPA-mediated induction of recombinant RhAG and RhD transcription was associated with an increased membrane expression of both RhAG and RhD proteins.	Tetradecanoylphorbol Acetate	61-64	Rh blood group D antigen	Homo sapiens	108-111
29531138-4	2018	In vitro analysis indicated that HMGB1, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-1beta (IL-1beta) were secreted in response to tumor necrosis factor-alpha (TNF-alpha) stimuli in human gingival epithelial cells (HGECs) and human monocytic leukemia cells (THP-1) treated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	308-333	colony stimulating factor 2	Homo sapiens	90-96
12118064-2	2002	In this study, we show that synaptotagmin II (Syt II), a member of the Syt family of proteins, is required for TPA-induced degradation of PKCalpha.	Tetradecanoylphorbol Acetate	111-114	synaptotagmin 2	Rattus norvegicus	28-44
12118064-2	2002	In this study, we show that synaptotagmin II (Syt II), a member of the Syt family of proteins, is required for TPA-induced degradation of PKCalpha.	Tetradecanoylphorbol Acetate	111-114	synaptotagmin 2	Rattus norvegicus	46-52
12118064-3	2002	Thus, whereas the kinase half-life in TPA-treated cultured mast cells (the mast cell line rat basophilic leukemia RBL-2H3) is 2 hours, it is doubled in RBL-Syt II(-) cells, in which the cellular level of Syt II is reduced by &gt;95% by transfection with Syt II antisense cDNA.	Tetradecanoylphorbol Acetate	38-41	synaptotagmin 2	Rattus norvegicus	156-162
12118064-3	2002	Thus, whereas the kinase half-life in TPA-treated cultured mast cells (the mast cell line rat basophilic leukemia RBL-2H3) is 2 hours, it is doubled in RBL-Syt II(-) cells, in which the cellular level of Syt II is reduced by &gt;95% by transfection with Syt II antisense cDNA.	Tetradecanoylphorbol Acetate	38-41	synaptotagmin 2	Rattus norvegicus	204-210
12118064-3	2002	Thus, whereas the kinase half-life in TPA-treated cultured mast cells (the mast cell line rat basophilic leukemia RBL-2H3) is 2 hours, it is doubled in RBL-Syt II(-) cells, in which the cellular level of Syt II is reduced by &gt;95% by transfection with Syt II antisense cDNA.	Tetradecanoylphorbol Acetate	38-41	synaptotagmin 2	Rattus norvegicus	204-210
12118064-5	2002	By contrast, in TPA-treated RBL-Syt II(-) cells, PKCalpha is diverted to recycling endosomes and remains distributed between the plasma membrane and the perinuclear recycling endocytic compartment.	Tetradecanoylphorbol Acetate	16-19	synaptotagmin 2	Rattus norvegicus	32-38
29710490-8	2018	Therefore, the result demonstrates that the anti-metastatic effects of a proton beam in TPA-treated HepG2 cells are associated with the inhibition of MMP-9 activity and the down-regulations of MMP-9, uPA, uPAR, Snail-1 and VEGF gene expression via the p38 MAPK/c-Fos signaling pathway.	Tetradecanoylphorbol Acetate	88-91	plasminogen activator, urokinase receptor	Homo sapiens	205-209
12118374-12	2002	Taken together, our data demonstrate that PMA-mediated inhibition of apoptosis is a complex process that is integrated at both the transcriptional and post-transcriptional level and point out to the potential role of Mcl-1, Bcl-x, c-Myc and survivin in this process.	Tetradecanoylphorbol Acetate	42-45	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	217-222
29324332-8	2018	Apparent Kd correlated with LT (r=0.43, p=0.037), tissue plasminogen activator-plasminogen activator inhibitor 1 (tPA-PAI-1) complexes (r=0.63, p=0.012), and active PAI-1 (r=0.49, p=0.03).	Tetradecanoylphorbol Acetate	114-117	serpin family E member 1	Homo sapiens	118-123
12118374-12	2002	Taken together, our data demonstrate that PMA-mediated inhibition of apoptosis is a complex process that is integrated at both the transcriptional and post-transcriptional level and point out to the potential role of Mcl-1, Bcl-x, c-Myc and survivin in this process.	Tetradecanoylphorbol Acetate	42-45	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	231-236
15304041-6	2004	TF expression was induced by interleukin (IL)-1 or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	51-82	coagulation factor III, tissue factor	Homo sapiens	0-2
15304041-6	2004	TF expression was induced by interleukin (IL)-1 or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	84-87	coagulation factor III, tissue factor	Homo sapiens	0-2
29207123-7	2018	In conclusion, berberine reduced NLRP3 inflammasone expression by suppressing the activation of the TLR4/Myd88/NF-kappaB signaling pathway in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	142-145	toll like receptor 4	Homo sapiens	100-104
15184881-4	2004	However, in cultured prostate cancer cells, the REPS2-p65 interaction is triggered upon stimulation with phorbol ester (PMA).	Tetradecanoylphorbol Acetate	120-123	RALBP1 associated Eps domain containing 2	Homo sapiens	48-53
29079502-5	2018	For FeCl3-induced ischemia/thrombolysis experiments, 10% FeCl3 was preferred so as to obtain reperfusion with tPA in CD1 mice.	Tetradecanoylphorbol Acetate	110-113	CD1 antigen complex	Mus musculus	117-120
15197142-4	2004	Alpha-tocopherol (50 to 500 microg/mL) inhibited thrombin-induced or phorbol 12-myristate 13-acetate (PMA)-induced P-selectin expression on platelets.	Tetradecanoylphorbol Acetate	69-100	selectin P	Homo sapiens	115-125
15197142-4	2004	Alpha-tocopherol (50 to 500 microg/mL) inhibited thrombin-induced or phorbol 12-myristate 13-acetate (PMA)-induced P-selectin expression on platelets.	Tetradecanoylphorbol Acetate	102-105	selectin P	Homo sapiens	115-125
11971895-3	2002	The BZLF1 gene can be induced for expression by activating agents, such as transforming growth factor-beta (TGF-beta) and 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	122-158	protein Zta	Human gammaherpesvirus 4	4-9
12191496-6	2002	Accordingly, PMA induced rapid phosphorylation of MEK substrate, i.e. Erk1/2 (p42/44 MAPK).	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase 20	Homo sapiens	78-81
29178986-0	2018	Thrombolytic fucoidans inhibit the tPA-PAI1 complex, indicating activation of plasma tissue-type plasminogen activator is a mechanism of fucoidan-mediated thrombolysis in a mouse thrombosis model.	Tetradecanoylphorbol Acetate	35-38	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	39-43
12769655-3	2002	Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily, is the principal inhibitor of tPA and uPA in the fibrinolytic system.	Tetradecanoylphorbol Acetate	137-140	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	0-33
12769655-3	2002	Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily, is the principal inhibitor of tPA and uPA in the fibrinolytic system.	Tetradecanoylphorbol Acetate	137-140	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	35-40
15228600-2	2004	When COS-7 cells transfected with AANAT cDNA were treated with phorbol 12-myristate 13-acetate (PMA), both the activity and protein level of AANAT were increased.	Tetradecanoylphorbol Acetate	63-94	aralkylamine N-acetyltransferase	Rattus norvegicus	34-39
15228600-2	2004	When COS-7 cells transfected with AANAT cDNA were treated with phorbol 12-myristate 13-acetate (PMA), both the activity and protein level of AANAT were increased.	Tetradecanoylphorbol Acetate	63-94	aralkylamine N-acetyltransferase	Rattus norvegicus	141-146
11986211-3	2002	In the presence of serum and phorbol 12-myristate 13-acetate (PMA), a PKC activator, cells exhibited full megakaryocytic differentiation, manifested by adhesion, shape change, increased cell size, polyploidy, PPF, and expression of CD41(+), CD61(+), and CD62P(+).	Tetradecanoylphorbol Acetate	29-60	selectin P	Homo sapiens	254-259
29259250-4	2017	According to deletion mapping and site directed mutagenesis analysis, the TPA-responsive elements on both MMP9 and ZEB1 promoters locate on a putative EGR1 and SP1 overlapping region coupled with an upstream proposed Snail binding motif TCACA.	Tetradecanoylphorbol Acetate	74-77	early growth response 1	Homo sapiens	151-155
11986211-3	2002	In the presence of serum and phorbol 12-myristate 13-acetate (PMA), a PKC activator, cells exhibited full megakaryocytic differentiation, manifested by adhesion, shape change, increased cell size, polyploidy, PPF, and expression of CD41(+), CD61(+), and CD62P(+).	Tetradecanoylphorbol Acetate	62-65	selectin P	Homo sapiens	254-259
12082637-4	2002	A RNase-protection analysis showed that PMA stimulated the expression of several known anti-apoptotic genes (TRAF1, TRAF4, c-IAP-1, c-IAP-2, Bfl-1, Bcl-xl).	Tetradecanoylphorbol Acetate	40-43	baculoviral IAP repeat containing 3	Homo sapiens	132-139
15067002-11	2004	Taken together, the present results indicate that the TPA-induced down-regulation of melanogenesis is mediated by PLD2 but not by PLD1 through the ubiquitin proteasome-mediated degradation of tyrosinase.	Tetradecanoylphorbol Acetate	54-57	phospholipase D2	Mus musculus	114-118
15067002-11	2004	Taken together, the present results indicate that the TPA-induced down-regulation of melanogenesis is mediated by PLD2 but not by PLD1 through the ubiquitin proteasome-mediated degradation of tyrosinase.	Tetradecanoylphorbol Acetate	54-57	tyrosinase	Mus musculus	192-202
29259250-5	2017	Consistently, chromatin immunoprecipitation (ChIP) assay showed TPA triggered binding of Snail, EGR1 and SP1 on MMP9 and ZEB1 promoters.	Tetradecanoylphorbol Acetate	64-67	early growth response 1	Homo sapiens	96-100
15175025-7	2004	Phorbol-12-myristate-13-acetate (PMA) induced the expression of PAI-1, and pre-treatment with Ro 31-8220 (a PKC inhibitor) markedly suppressed SPC-induced PAI-1 expression.	Tetradecanoylphorbol Acetate	0-31	serpin family E member 1	Homo sapiens	64-69
29259250-6	2017	Double ChIP further indicated TPA induced association of Snail with EGR1 and SP1 on both promoters.	Tetradecanoylphorbol Acetate	30-33	early growth response 1	Homo sapiens	68-72
15175025-7	2004	Phorbol-12-myristate-13-acetate (PMA) induced the expression of PAI-1, and pre-treatment with Ro 31-8220 (a PKC inhibitor) markedly suppressed SPC-induced PAI-1 expression.	Tetradecanoylphorbol Acetate	0-31	serpin family E member 1	Homo sapiens	155-160
15175025-7	2004	Phorbol-12-myristate-13-acetate (PMA) induced the expression of PAI-1, and pre-treatment with Ro 31-8220 (a PKC inhibitor) markedly suppressed SPC-induced PAI-1 expression.	Tetradecanoylphorbol Acetate	33-36	serpin family E member 1	Homo sapiens	64-69
15175025-7	2004	Phorbol-12-myristate-13-acetate (PMA) induced the expression of PAI-1, and pre-treatment with Ro 31-8220 (a PKC inhibitor) markedly suppressed SPC-induced PAI-1 expression.	Tetradecanoylphorbol Acetate	33-36	serpin family E member 1	Homo sapiens	155-160
29236713-8	2017	More mitochondrial reactive oxygen species (ROS) were generated in neutrophils and platelets of Sirt3-/- mice compared to WT, when stimulated with a low concentration of phorbol 12-myristate 13-acetate (PMA) and a high concentration of thrombin, respectively.	Tetradecanoylphorbol Acetate	170-201	sirtuin 3	Mus musculus	96-101
15037634-0	2004	Activation of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, by phorbol 12-myristate 13-acetate (PMA) suppresses glucose transport into astroglioma cells via the glucose transporter-1 (GLUT-1).	Tetradecanoylphorbol Acetate	82-113	syntaxin 1A	Homo sapiens	60-65
15037634-0	2004	Activation of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, by phorbol 12-myristate 13-acetate (PMA) suppresses glucose transport into astroglioma cells via the glucose transporter-1 (GLUT-1).	Tetradecanoylphorbol Acetate	82-113	syntaxin 1A	Homo sapiens	66-77
15037634-0	2004	Activation of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, by phorbol 12-myristate 13-acetate (PMA) suppresses glucose transport into astroglioma cells via the glucose transporter-1 (GLUT-1).	Tetradecanoylphorbol Acetate	115-118	syntaxin 1A	Homo sapiens	60-65
15037634-0	2004	Activation of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, by phorbol 12-myristate 13-acetate (PMA) suppresses glucose transport into astroglioma cells via the glucose transporter-1 (GLUT-1).	Tetradecanoylphorbol Acetate	115-118	syntaxin 1A	Homo sapiens	66-77
29236713-8	2017	More mitochondrial reactive oxygen species (ROS) were generated in neutrophils and platelets of Sirt3-/- mice compared to WT, when stimulated with a low concentration of phorbol 12-myristate 13-acetate (PMA) and a high concentration of thrombin, respectively.	Tetradecanoylphorbol Acetate	203-206	sirtuin 3	Mus musculus	96-101
28888989-4	2017	alpha1A-Adrenergic receptor interaction with beta-arrestins (colocalization/coimmunoprecipitation) was induced by noradrenaline and oxymetazoline and, to a lesser extent, by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	174-199	adrenoceptor alpha 1D	Homo sapiens	0-27
15126071-7	2004	Activation of T cells by phorbol-12-myristate-13-acetate (PMA) resulted in markedly enhanced binding activities to the NF-AT site, which significantly increased upon addition of OP, indicating that the transcription factor NF-AT was involved in the enhancing effect of OP on IL-4 production.	Tetradecanoylphorbol Acetate	25-56	interleukin 4	Mus musculus	275-279
15126071-7	2004	Activation of T cells by phorbol-12-myristate-13-acetate (PMA) resulted in markedly enhanced binding activities to the NF-AT site, which significantly increased upon addition of OP, indicating that the transcription factor NF-AT was involved in the enhancing effect of OP on IL-4 production.	Tetradecanoylphorbol Acetate	58-61	interleukin 4	Mus musculus	275-279
28765923-0	2017	Bombyx mori hemocyte extract has anti-inflammatory effects on human phorbol myristate acetate-differentiated THP-1 cells via TLR4-mediated suppression of the NF-kappaB signaling pathway.	Tetradecanoylphorbol Acetate	68-93	toll like receptor 4	Homo sapiens	125-129
14759225-8	2004	In line with this, the DAG produced after PMA exposure was consumed more rapidly in McA-ECT1 cells and the CDPethanolamine level decreased accordingly.	Tetradecanoylphorbol Acetate	42-45	fibroblast growth factor receptor 2	Homo sapiens	88-92
14977566-6	2004	We studied effects of IFN-beta1a therapy on IFNGR expression on PMA/ionomycin-stimulated PBMNC"s in 29 patients with active and stable MS.	Tetradecanoylphorbol Acetate	64-67	interferon gamma receptor 1	Homo sapiens	44-49
15033458-0	2004	Expressions of inhibitory Smads, Smad6 and Smad7, are differentially regulated by TPA in human lung fibroblast cells.	Tetradecanoylphorbol Acetate	82-85	SMAD family member 6	Homo sapiens	33-38
28687976-6	2017	The tPA-dependent initial rate of plasmin generation (IRPG) in zinc-treated U937/PR9 increased by 2.13-fold, and cell invasiveness increased by 27.6%.	Tetradecanoylphorbol Acetate	4-7	Picrotoxin-resistant	Drosophila melanogaster	81-84
15033458-2	2004	Here, we show that phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) down-regulates Smad6 mRNA expression and up-regulates Smad7 mRNA expression in IMR-90, a human lung fibroblast cell line.	Tetradecanoylphorbol Acetate	33-69	SMAD family member 6	Homo sapiens	91-96
15033458-2	2004	Here, we show that phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) down-regulates Smad6 mRNA expression and up-regulates Smad7 mRNA expression in IMR-90, a human lung fibroblast cell line.	Tetradecanoylphorbol Acetate	71-74	SMAD family member 6	Homo sapiens	91-96
15033458-4	2004	TPA treatment had little effect on the phosphorylation of novel PKCs (PKCdelta and PKCepsilon), but specifically induced PKCmu phosphorylation, and this effect was inhibited by Go6983, but not by Go6976.	Tetradecanoylphorbol Acetate	0-3	protein kinase C epsilon	Homo sapiens	83-93
15059889-2	2004	Stat1, Stat3, and Stat5 were activated in mouse epidermis after treatment with different classes of tumor promoters, including 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and chrysarobin.	Tetradecanoylphorbol Acetate	127-163	signal transducer and activator of transcription 5A	Mus musculus	18-23
15059889-2	2004	Stat1, Stat3, and Stat5 were activated in mouse epidermis after treatment with different classes of tumor promoters, including 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and chrysarobin.	Tetradecanoylphorbol Acetate	165-168	signal transducer and activator of transcription 5A	Mus musculus	18-23
15059889-3	2004	In addition, Stat1, Stat3, and Stat5 were constitutively activated in skin tumors generated by the two-stage carcinogenesis regimen using 7,12-dimethylbenz(a)anthracene as initiator and TPA as promoter.	Tetradecanoylphorbol Acetate	186-189	signal transducer and activator of transcription 5A	Mus musculus	31-36
28878626-8	2017	Finally, the expression of a dominant negative version of H-Ras, an upstream activator of ERK1/2, abolishes phorbol 12-myristate 13-acetate (PMA)-mediated down regulation of NET in a manner similar to MKP3.	Tetradecanoylphorbol Acetate	108-139	HRas proto-oncogene, GTPase	Rattus norvegicus	58-63
15059889-7	2004	Abrogation of EGFR function in mouse epidermis using an EGFR kinase inhibitor or by overexpressing a dominant negative form of EGFR led to a reduction in Stat3 activation in response to TPA treatment.	Tetradecanoylphorbol Acetate	186-189	epidermal growth factor receptor	Mus musculus	14-18
15059889-7	2004	Abrogation of EGFR function in mouse epidermis using an EGFR kinase inhibitor or by overexpressing a dominant negative form of EGFR led to a reduction in Stat3 activation in response to TPA treatment.	Tetradecanoylphorbol Acetate	186-189	epidermal growth factor receptor	Mus musculus	56-60
15059889-7	2004	Abrogation of EGFR function in mouse epidermis using an EGFR kinase inhibitor or by overexpressing a dominant negative form of EGFR led to a reduction in Stat3 activation in response to TPA treatment.	Tetradecanoylphorbol Acetate	186-189	epidermal growth factor receptor	Mus musculus	56-60
28878626-8	2017	Finally, the expression of a dominant negative version of H-Ras, an upstream activator of ERK1/2, abolishes phorbol 12-myristate 13-acetate (PMA)-mediated down regulation of NET in a manner similar to MKP3.	Tetradecanoylphorbol Acetate	141-144	HRas proto-oncogene, GTPase	Rattus norvegicus	58-63
14709331-4	2004	In addition, in cells depleted of diacylglycerol-sensitive PKC by prolonged treatment with 4beta-phorbol 12beta-myristate 13alpha-acetate (PMA), the stimulatory effects of PGF2alpha on glucose transport and GLUT1 mRNA accumulation were both inhibited.	Tetradecanoylphorbol Acetate	139-142	protein kinase C epsilon	Homo sapiens	59-62
28235798-4	2017	Incubation of the L-selectin tail with cell extracts from phorbol 12-myristate 13-acetate-stimulated Raw 264.7 macrophages resulted in the binding of mu1A of the clathrin-coated vesicle AP-1 complex.	Tetradecanoylphorbol Acetate	58-89	selectin L	Homo sapiens	18-28
15487498-15	2004	In addition, we have in silico cloned a novel mouse gene, ORF32 (open reading frame 32) with TPA accession number of BK000258, which is the mouse ortholog of human C17orf32.	Tetradecanoylphorbol Acetate	93-96	transmembrane protein 199	Homo sapiens	164-172
15081539-7	2004	These results together with our previous ones showing that the TPA-induced up regulation of Pyst2-L mRNA was only partially inhibited by the use of a specific Mek1/2 inhibitor, lead us to ask whether the Pyst2-L phosphatase has a monogamous relationship with the Erk2 protein.	Tetradecanoylphorbol Acetate	63-66	mitogen-activated protein kinase kinase 1	Homo sapiens	159-165
27249540-4	2017	Furthermore, there was a significant increase in the nuclear dimeric form of PKM2 in the PMA-induced U1 cells in comparison to PMA-induced U937 cells.	Tetradecanoylphorbol Acetate	89-92	pyruvate kinase M1/2	Homo sapiens	77-81
15020199-8	2004	Employing Western blot analysis, we found that oleandrin application to mouse skin resulted in inhibition of TPA-induced activation of NF-kappaB, IKKalpha and phosphorylation and degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	109-112	conserved helix-loop-helix ubiquitous kinase	Mus musculus	146-154
14996721-9	2004	Cell culture experiments demonstrated that BTG2 expression was weakly inducible by the phorbolester 12-O-tetradecanoylphorbol-13-acetate in one of four cRCC cell lines.	Tetradecanoylphorbol Acetate	100-136	BTG anti-proliferation factor 2	Homo sapiens	43-47
15005710-5	2004	Surprisingly, the c-Fos induced by the YXXQ-signal alone was localized to the cytoplasm, from which it translocated into the nucleus following TPA (12-O-tetradecanoyl-phorbol 13-acetate) treatment in a MEK/Erk-dependent manner.	Tetradecanoylphorbol Acetate	143-146	FBJ osteosarcoma oncogene	Mus musculus	18-23
15005710-5	2004	Surprisingly, the c-Fos induced by the YXXQ-signal alone was localized to the cytoplasm, from which it translocated into the nucleus following TPA (12-O-tetradecanoyl-phorbol 13-acetate) treatment in a MEK/Erk-dependent manner.	Tetradecanoylphorbol Acetate	148-185	FBJ osteosarcoma oncogene	Mus musculus	18-23
27249540-4	2017	Furthermore, there was a significant increase in the nuclear dimeric form of PKM2 in the PMA-induced U1 cells in comparison to PMA-induced U937 cells.	Tetradecanoylphorbol Acetate	127-130	pyruvate kinase M1/2	Homo sapiens	77-81
28351321-6	2017	We demonstrate that temsirolimus and torin 1 effectively reduced the constitutive as well as phorbol-myristate-acetate/oncostatin-M-induced expression of mesenchymal markers (fibronectin, vimentin, and YKL40) and neural stem cell markers (Sox2, Oct4, nestin, and mushashi1).	Tetradecanoylphorbol Acetate	93-118	vimentin	Homo sapiens	188-196
15030177-7	2004	However, phorbol ester (PMA) stimulation of cells cultured in high glucose significantly enhanced membrane association of PKC betaI and Arf6, but not Arf3.	Tetradecanoylphorbol Acetate	24-27	ADP ribosylation factor 6	Homo sapiens	136-140
28351321-6	2017	We demonstrate that temsirolimus and torin 1 effectively reduced the constitutive as well as phorbol-myristate-acetate/oncostatin-M-induced expression of mesenchymal markers (fibronectin, vimentin, and YKL40) and neural stem cell markers (Sox2, Oct4, nestin, and mushashi1).	Tetradecanoylphorbol Acetate	93-118	POU class 5 homeobox 1	Homo sapiens	245-249
14605869-6	2004	Stimulation of primary neurons with glutamate, KCl, phorbol 12-myristate 13-acetate, and leukemia inhibitory factor appreciably increased the level of c-Fos but not of Cdkl2 transcripts.	Tetradecanoylphorbol Acetate	52-83	FBJ osteosarcoma oncogene	Mus musculus	151-156
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	73-109	Kruppel like factor 10	Homo sapiens	206-211
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	111-114	Kruppel like factor 10	Homo sapiens	206-211
14732702-3	2004	Our data showed that the heteromeric GIRK1/GIRK4 channels were inhibited by a PKC activator phorbol 12-myristate 13-acetate (PMA) through reduction of single channel open-state probability.	Tetradecanoylphorbol Acetate	92-123	potassium inwardly rectifying channel subfamily J member 5 L homeolog	Xenopus laevis	43-48
29098164-8	2017	We found that MISP, KLF10, KLF15, PPP1R18, and RXRbeta proteins could strongly respond to TPA stimulation and activate LCN2 transcriptional expression.	Tetradecanoylphorbol Acetate	90-93	Kruppel like factor 10	Homo sapiens	20-25
14732702-3	2004	Our data showed that the heteromeric GIRK1/GIRK4 channels were inhibited by a PKC activator phorbol 12-myristate 13-acetate (PMA) through reduction of single channel open-state probability.	Tetradecanoylphorbol Acetate	125-128	potassium inwardly rectifying channel subfamily J member 5 L homeolog	Xenopus laevis	43-48
28119748-0	2017	Mometasone Furoate Suppresses PMA-Induced MUC-5AC and MUC-2 Production in Human Airway Epithelial Cells.	Tetradecanoylphorbol Acetate	30-33	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	42-49
27521797-6	2016	PMA caused oxidative stress in the embryos as demonstrated by decreased mRNA expression of catalase and superoxide dismutase 2.	Tetradecanoylphorbol Acetate	0-3	catalase	Danio rerio	91-99
14670623-0	2004	Differential regulation of vimentin mRNA by 12-O-tetradecanoylphorbol 13-acetate and all-trans-retinoic acid correlates with motility of Hep 3B human hepatocellular carcinoma cells.	Tetradecanoylphorbol Acetate	44-80	vimentin	Homo sapiens	27-35
14670623-3	2004	We studied the regulation of vimentin mRNA and multistep invasion processes following treatment of 12-O-tetradecanoylphorbol 13-acetate (TPA) and all-trans-retinoic acid (RA) in Hep 3B hepatocellular carcinoma cells.	Tetradecanoylphorbol Acetate	99-135	vimentin	Homo sapiens	29-37
14670623-3	2004	We studied the regulation of vimentin mRNA and multistep invasion processes following treatment of 12-O-tetradecanoylphorbol 13-acetate (TPA) and all-trans-retinoic acid (RA) in Hep 3B hepatocellular carcinoma cells.	Tetradecanoylphorbol Acetate	137-140	vimentin	Homo sapiens	29-37
14670623-4	2004	TPA showed marked induction of vimentin mRNA, while RA decreased the mRNA level.	Tetradecanoylphorbol Acetate	0-3	vimentin	Homo sapiens	31-39
27464843-6	2016	MR epidermal knockout mice showed increased susceptibility to phorbol 12-myristate 13-acetate-induced inflammation with higher cytokine induction.	Tetradecanoylphorbol Acetate	62-93	nuclear receptor subfamily 3, group C, member 2	Mus musculus	0-2
14670623-7	2004	These findings suggest that TPA and RA could modulate the invasive potential of Hep 3B cells by altering cellular motility related to differential regulation of vimentin mRNA.	Tetradecanoylphorbol Acetate	28-31	vimentin	Homo sapiens	161-169
14573593-5	2004	Similarly, blockade of the effect of HB-EGF with the selective inhibitor CRM197 or a neutralizing antibody attenuated signals generated by GnRH and phorbol 12-myristate 13-acetate, but not those stimulated by EGF.	Tetradecanoylphorbol Acetate	148-179	heparin-binding EGF-like growth factor	Mus musculus	37-43
14573593-5	2004	Similarly, blockade of the effect of HB-EGF with the selective inhibitor CRM197 or a neutralizing antibody attenuated signals generated by GnRH and phorbol 12-myristate 13-acetate, but not those stimulated by EGF.	Tetradecanoylphorbol Acetate	148-179	epidermal growth factor	Mus musculus	40-43
27464843-7	2016	Likewise, cultured MR epidermal knockout keratinocytes had increased phorbol 12-myristate 13-acetate-induced NF-kappaB activation, highlighting an anti-inflammatory function for MR.	Tetradecanoylphorbol Acetate	69-100	nuclear receptor subfamily 3, group C, member 2	Mus musculus	19-21
27586664-7	2016	We describe dye uptake, interpreted as connexin dependent, that is shown to be enhanced with reduced extracellular Ca2+, mechanically responsive, inhibited by TPA, inhibited by EL186 antibodies for Cx43 and sustained for more than 15 min following mechanical stimulation.	Tetradecanoylphorbol Acetate	159-162	LOC100128922	Homo sapiens	39-47
14709893-0	2004	Phorbol myristate acetate stimulates degradation of a structural analogue of platelet-activating factor to a neutral lipid in human leukemic K562 cells: relevance to the release of lipids.	Tetradecanoylphorbol Acetate	0-25	PCNA clamp associated factor	Homo sapiens	77-103
14709893-3	2004	Phorbol myristate acetate (PMA) was found to stimulate the release of two radioactive lipids, ethylcarbamyl-PAF itself and its metabolite, 1-O-octadecyl-2-ethylcarbamyl-sn-glycerol, whereas only ethylcarbamyl-PAF was released from the resting cells.	Tetradecanoylphorbol Acetate	0-25	PCNA clamp associated factor	Homo sapiens	108-111
14709893-3	2004	Phorbol myristate acetate (PMA) was found to stimulate the release of two radioactive lipids, ethylcarbamyl-PAF itself and its metabolite, 1-O-octadecyl-2-ethylcarbamyl-sn-glycerol, whereas only ethylcarbamyl-PAF was released from the resting cells.	Tetradecanoylphorbol Acetate	0-25	PCNA clamp associated factor	Homo sapiens	209-212
14709893-3	2004	Phorbol myristate acetate (PMA) was found to stimulate the release of two radioactive lipids, ethylcarbamyl-PAF itself and its metabolite, 1-O-octadecyl-2-ethylcarbamyl-sn-glycerol, whereas only ethylcarbamyl-PAF was released from the resting cells.	Tetradecanoylphorbol Acetate	27-30	PCNA clamp associated factor	Homo sapiens	108-111
14709893-3	2004	Phorbol myristate acetate (PMA) was found to stimulate the release of two radioactive lipids, ethylcarbamyl-PAF itself and its metabolite, 1-O-octadecyl-2-ethylcarbamyl-sn-glycerol, whereas only ethylcarbamyl-PAF was released from the resting cells.	Tetradecanoylphorbol Acetate	27-30	PCNA clamp associated factor	Homo sapiens	209-212
14709893-4	2004	The increased release of radioactive lipids in PMA-stimulated cells was suggested to be due to stimulated degradation of intracellular ethylcarbamyl-PAF into the cell-permeable metabolite.	Tetradecanoylphorbol Acetate	47-50	PCNA clamp associated factor	Homo sapiens	149-152
27876785-7	2016	SDS-PAGE showed that annonacinone inhibited formation of PAI-1/tPA complex via enhancement of the substrate pathway.	Tetradecanoylphorbol Acetate	63-66	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	57-62
14757441-5	2004	Furthermore, when HL-60 myeloid leukemic cells were differentiated with phorbol ester (TPA), PBK/TOPK protein expression was strongly down-regulated by 24 h. Under these same conditions, phosphorylated c-Myc was rapidly down-regulated (by 4 h), while the levels of cyclin D1 and phosphorylated p38 were constant.	Tetradecanoylphorbol Acetate	87-90	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	202-207
14693697-3	2004	In contrast, responses to the pharmacologic activator 12-O-tetradecanoylphorbol-13-acetate (TPA) were reciprocally modulated by overexpression of the PKC alpha WT or PKC alpha KD but not the corresponding PKC delta adenoviruses.	Tetradecanoylphorbol Acetate	54-90	plasminogen activator, tissue type	Rattus norvegicus	92-95
27846317-5	2016	Phorbol 12-myristate 13-acetate stimulation (100 nM, 15 min) increased (p &lt; 0.05) and two ERK2 siRNAs as well as KRAS siRNAs decreased (p &lt; 0.05) PD-L1 expression.	Tetradecanoylphorbol Acetate	0-31	CD274 molecule	Homo sapiens	152-157
14630706-5	2004	In this study, we show that topical application of SC-560 (a COX-1 selective inhibitor) or celecoxib (COX-2 selective) to TPA-treated wild-type skin caused fivefold increases in the number of basal keratinocytes expressing the early differentiation marker keratin 1 (K1).	Tetradecanoylphorbol Acetate	122-125	keratin 1	Mus musculus	267-269
14673171-4	2004	We report here that ATF-3, JunB, and BRG-1 (the ATPase subunit of the 2-MDa human chromatin remodeling machine SWI/SNF) are recruited to the 3" boundary of nuc-1 following phorbol myristate acetate stimulation in Jurkat T cells.	Tetradecanoylphorbol Acetate	172-197	activating transcription factor 3	Homo sapiens	20-25
14673177-0	2004	Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events.	Tetradecanoylphorbol Acetate	0-31	colony stimulating factor 1	Homo sapiens	55-82
27404230-16	2016	Fibrin deposition and tPA activity, downstream targets of PAI-1, were also notably reduced in the HFD+THD group compared to the HFD group.	Tetradecanoylphorbol Acetate	22-25	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	58-63
14532285-8	2003	The effect of PKC-epsilon on hsp90 beta expression seems to be stimuli-specific, as phorbol myristate acetate-mediated hsp90 beta expression was PKC-epsilon-independent.	Tetradecanoylphorbol Acetate	84-109	heat shock protein 90 alpha family class B member 1	Homo sapiens	29-39
14532285-8	2003	The effect of PKC-epsilon on hsp90 beta expression seems to be stimuli-specific, as phorbol myristate acetate-mediated hsp90 beta expression was PKC-epsilon-independent.	Tetradecanoylphorbol Acetate	84-109	heat shock protein 90 alpha family class B member 1	Homo sapiens	119-129
14532285-8	2003	The effect of PKC-epsilon on hsp90 beta expression seems to be stimuli-specific, as phorbol myristate acetate-mediated hsp90 beta expression was PKC-epsilon-independent.	Tetradecanoylphorbol Acetate	84-109	protein kinase C epsilon	Homo sapiens	145-156
27777559-11	2016	Conclusion: Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	113-116	toll like receptor 4	Homo sapiens	70-74
12930725-6	2003	Treatment of cells expressing wild-type MARCKS-GFP with PGF2alpha and TPA resulted in translocation of MARCKS from the plasma membrane to the cytoplasm within 2.5 min.	Tetradecanoylphorbol Acetate	70-73	myristoylated alanine rich protein kinase C substrate	Bos taurus	40-50
12930725-6	2003	Treatment of cells expressing wild-type MARCKS-GFP with PGF2alpha and TPA resulted in translocation of MARCKS from the plasma membrane to the cytoplasm within 2.5 min.	Tetradecanoylphorbol Acetate	70-73	myristoylated alanine rich protein kinase C substrate	Bos taurus	40-46
27236113-9	2016	RESULTS: PMA/ionomycin and IL-17 plus INF-gamma stimulation resulted in a significant TF increase at gene and protein levels as well as at cell-surface expression.	Tetradecanoylphorbol Acetate	9-12	coagulation factor III, tissue factor	Homo sapiens	86-88
14647461-5	2003	In THP-1 cells differentiated to mature macrophage-like cells by PMA/TPA or ATRA, MLL-AF9 expression was downregulated.	Tetradecanoylphorbol Acetate	69-72	lysine methyltransferase 2A	Homo sapiens	82-85
12952982-6	2003	The overexpression of PACSIN3 in HT1080 cells enhanced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced proHB-EGF shedding.	Tetradecanoylphorbol Acetate	55-91	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	22-29
27373681-3	2016	Here, PMA was shown to induce lamellipodia formation and reorganization of the adhesion sites as well as actin and vimentin filaments independently of integrin preactivation.	Tetradecanoylphorbol Acetate	6-9	vimentin	Homo sapiens	115-123
12952982-6	2003	The overexpression of PACSIN3 in HT1080 cells enhanced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced proHB-EGF shedding.	Tetradecanoylphorbol Acetate	93-96	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	22-29
12952982-7	2003	Furthermore, knockdown of endogenous PACSIN3 by small interfering RNA in HT1080 cells significantly attenuated the shedding of proHB-EGF induced by TPA and angiotensin II.	Tetradecanoylphorbol Acetate	148-151	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	37-44
12952982-8	2003	Our data indicate that PACSIN3 has a novel function as an up-regulator in the signaling of proHB-EGF shedding induced by TPA and angiotensin II.	Tetradecanoylphorbol Acetate	121-124	protein kinase C and casein kinase substrate in neurons 3	Homo sapiens	23-30
14529724-2	2003	Here, we show that TPA-induced depression of synaptic transmission between granule cells and Purkinje cells in culture is mediated through activation of the MEK1/2-ERK1/2 pathway.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase kinase 1	Homo sapiens	157-163
14529724-3	2003	Phosphorylation of ERK1/2 induced by TPA and co-application of high potassium and glutamate was greatly attenuated by preincubating Purkinje cells with the MEK1/2 (MAPK ERK kinase 1/2) inhibitor PD98059.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase kinase 1	Homo sapiens	156-162
14529724-3	2003	Phosphorylation of ERK1/2 induced by TPA and co-application of high potassium and glutamate was greatly attenuated by preincubating Purkinje cells with the MEK1/2 (MAPK ERK kinase 1/2) inhibitor PD98059.	Tetradecanoylphorbol Acetate	37-40	mitogen-activated protein kinase kinase 1	Homo sapiens	164-183
14529724-5	2003	The MEK1/2 inhibitor also suppressed declustering of the ionotropic glutamate receptor subunit 2/3 (GluR2/3) induced by TPA and co-application of high potassium and glutamate, even though phosphorylation of Ser880 of GluR2/3 was not inhibited significantly in the presence of PD98059.	Tetradecanoylphorbol Acetate	120-123	mitogen-activated protein kinase kinase 1	Homo sapiens	4-10
12947120-3	2003	Here we found that 12-O-tetradecanoylphorbol-13-acetate (TPA) could induce cell apoptosis via induction of TR3 and E2F1 expression in LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	19-55	E2F transcription factor 1	Homo sapiens	115-119
12801884-5	2003	Indeed, cAMP- and TPA-mediated dephosphorylation of CRHSP-24 was fully inhibited by the PP1/PP2A inhibitor calyculin A, indicating that the protein is regulated by an additional phosphatase other than PP2B.	Tetradecanoylphorbol Acetate	18-21	protein phosphatase 2 phosphatase activator	Homo sapiens	92-96
14505317-6	2003	RESULTS: We have successfully applied the assays to evaluate (a) activation of E-selectin (CD62E) expression by interleukin-1beta in human umbilical vein endothelial cells (HUVECs), (b) induction of CD3 by phorbol-12-myristate-13-acetate in freshly prepared human peripheral blood lymphocytes, and (c) staurosporine-induced apoptosis in HUVEC and normal human dermal fibroblasts.	Tetradecanoylphorbol Acetate	206-237	selectin E	Homo sapiens	79-89
14505317-6	2003	RESULTS: We have successfully applied the assays to evaluate (a) activation of E-selectin (CD62E) expression by interleukin-1beta in human umbilical vein endothelial cells (HUVECs), (b) induction of CD3 by phorbol-12-myristate-13-acetate in freshly prepared human peripheral blood lymphocytes, and (c) staurosporine-induced apoptosis in HUVEC and normal human dermal fibroblasts.	Tetradecanoylphorbol Acetate	206-237	selectin E	Homo sapiens	91-96
12878595-5	2003	VCAM-1 release can be rapidly simulated by phorbol 12-myristate 13-acetate (PMA), and this induced VCAM-1 shedding is mediated by metalloproteinase cleavage of VCAM-1 near the transmembrane domain.	Tetradecanoylphorbol Acetate	43-74	vascular cell adhesion molecule 1	Mus musculus	0-6
12878595-5	2003	VCAM-1 release can be rapidly simulated by phorbol 12-myristate 13-acetate (PMA), and this induced VCAM-1 shedding is mediated by metalloproteinase cleavage of VCAM-1 near the transmembrane domain.	Tetradecanoylphorbol Acetate	43-74	vascular cell adhesion molecule 1	Mus musculus	99-105
12878595-5	2003	VCAM-1 release can be rapidly simulated by phorbol 12-myristate 13-acetate (PMA), and this induced VCAM-1 shedding is mediated by metalloproteinase cleavage of VCAM-1 near the transmembrane domain.	Tetradecanoylphorbol Acetate	43-74	vascular cell adhesion molecule 1	Mus musculus	99-105
12878595-5	2003	VCAM-1 release can be rapidly simulated by phorbol 12-myristate 13-acetate (PMA), and this induced VCAM-1 shedding is mediated by metalloproteinase cleavage of VCAM-1 near the transmembrane domain.	Tetradecanoylphorbol Acetate	76-79	vascular cell adhesion molecule 1	Mus musculus	0-6
12878595-5	2003	VCAM-1 release can be rapidly simulated by phorbol 12-myristate 13-acetate (PMA), and this induced VCAM-1 shedding is mediated by metalloproteinase cleavage of VCAM-1 near the transmembrane domain.	Tetradecanoylphorbol Acetate	76-79	vascular cell adhesion molecule 1	Mus musculus	99-105
12878595-5	2003	VCAM-1 release can be rapidly simulated by phorbol 12-myristate 13-acetate (PMA), and this induced VCAM-1 shedding is mediated by metalloproteinase cleavage of VCAM-1 near the transmembrane domain.	Tetradecanoylphorbol Acetate	76-79	vascular cell adhesion molecule 1	Mus musculus	99-105
12826681-5	2003	PTP alpha becomes activated in vivo after TPA stimulation.	Tetradecanoylphorbol Acetate	42-45	protein phosphatase 2 phosphatase activator	Rattus norvegicus	0-9
12826681-7	2003	To further substantiate our data, we show that cells lacking PKC delta have a markedly reduced PTP alpha and Src activity after 12-O-tetradecanoylphorbol-13-acetate stimulation.	Tetradecanoylphorbol Acetate	128-164	protein phosphatase 2 phosphatase activator	Rattus norvegicus	95-104
12826681-8	2003	These data support a model in which the main mechanism of 12-O-tetradecanoylphorbol-13-acetate-induced Src activation is the direct phosphorylation and activation of PTP alpha by PKC delta, which in turn dephosphorylates and activates Src.	Tetradecanoylphorbol Acetate	58-94	protein phosphatase 2 phosphatase activator	Rattus norvegicus	166-175
12927787-7	2003	NKIAMRE is activated by treatment of cells with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	48-79	cyclin dependent kinase like 3	Homo sapiens	0-7
12844482-8	2003	Curcumin treatment attenuated TPA- stimulated NF-kappaB activation in mouse skin, which was associated with its blockade of degradation of the inhibitory protein IkappaBalpha and also of subsequent translocation of the p65 subunit to nucleus.	Tetradecanoylphorbol Acetate	30-33	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	219-222
12915572-6	2003	Furthermore, chromatin immunoprecipitation assay results showed that the endogenous C/EBPalpha, RTA, and RAP proteins all associate with RTA promoter sequences in tetradecanoyl phorbol acetate-induced primary effusion lymphoma (PEL) cells.	Tetradecanoylphorbol Acetate	163-192	LDL receptor related protein associated protein 1	Homo sapiens	105-108
12766168-3	2003	Here, we show that non-transformed T cell lines obtained from XLP patients were defective in several activation events such as IL-2 production, CD25 expression, and homotypic cell aggregation when cells were stimulated via T cell antigen receptor (TCR).CD3 but not when early TCR-dependent events were bypassed by stimulation with phorbol 12-myristate 13-acetate/ionomycin.	Tetradecanoylphorbol Acetate	331-362	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	223-246
12766168-3	2003	Here, we show that non-transformed T cell lines obtained from XLP patients were defective in several activation events such as IL-2 production, CD25 expression, and homotypic cell aggregation when cells were stimulated via T cell antigen receptor (TCR).CD3 but not when early TCR-dependent events were bypassed by stimulation with phorbol 12-myristate 13-acetate/ionomycin.	Tetradecanoylphorbol Acetate	331-362	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	248-251
12881712-5	2003	The expression of the death adapter FADD and caspase-8 was required for Fas-induced FOXO3a cleavage, but activation of survival pathways by overexpression of FLICE-inhibitory protein or phorbol myristate acetate treatment prevented it.	Tetradecanoylphorbol Acetate	186-211	Fas associated via death domain	Homo sapiens	36-40
12890888-6	2003	Pretreatment with phorbol-12-myristate-13-acetate, which induces the expression of antiapoptotic Bcl-2, inhibited thapsigargin-induced degradation of caspases-9 and -3, but not caspase-12-like protein degradation.	Tetradecanoylphorbol Acetate	18-49	caspase 9	Homo sapiens	150-167
12792650-7	2003	Caspase-9 is phosphorylated at Thr 125, a conserved MAPK consensus site targeted by ERK2 in vitro, in a MEK-dependent manner in cells stimulated with epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	183-219	caspase 9	Homo sapiens	0-9
12792650-7	2003	Caspase-9 is phosphorylated at Thr 125, a conserved MAPK consensus site targeted by ERK2 in vitro, in a MEK-dependent manner in cells stimulated with epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	221-224	caspase 9	Homo sapiens	0-9
12682075-2	2003	Previously, we have shown that the transcriptional stimulation of SPRR1B expression by phorbol 12-myristate 13-acetate (PMA) is mainly mediated by a -150/-94 bp enhancer harboring two critical 12-O-tetradecanoylphorbol-13-acetate-responsive elements (TREs) and by Jun.Fra-1 dimers.	Tetradecanoylphorbol Acetate	87-118	small proline rich protein 1B	Homo sapiens	66-72
12682075-2	2003	Previously, we have shown that the transcriptional stimulation of SPRR1B expression by phorbol 12-myristate 13-acetate (PMA) is mainly mediated by a -150/-94 bp enhancer harboring two critical 12-O-tetradecanoylphorbol-13-acetate-responsive elements (TREs) and by Jun.Fra-1 dimers.	Tetradecanoylphorbol Acetate	87-118	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	268-273
12682075-2	2003	Previously, we have shown that the transcriptional stimulation of SPRR1B expression by phorbol 12-myristate 13-acetate (PMA) is mainly mediated by a -150/-94 bp enhancer harboring two critical 12-O-tetradecanoylphorbol-13-acetate-responsive elements (TREs) and by Jun.Fra-1 dimers.	Tetradecanoylphorbol Acetate	120-123	small proline rich protein 1B	Homo sapiens	66-72
12682075-2	2003	Previously, we have shown that the transcriptional stimulation of SPRR1B expression by phorbol 12-myristate 13-acetate (PMA) is mainly mediated by a -150/-94 bp enhancer harboring two critical 12-O-tetradecanoylphorbol-13-acetate-responsive elements (TREs) and by Jun.Fra-1 dimers.	Tetradecanoylphorbol Acetate	120-123	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	268-273
12682075-2	2003	Previously, we have shown that the transcriptional stimulation of SPRR1B expression by phorbol 12-myristate 13-acetate (PMA) is mainly mediated by a -150/-94 bp enhancer harboring two critical 12-O-tetradecanoylphorbol-13-acetate-responsive elements (TREs) and by Jun.Fra-1 dimers.	Tetradecanoylphorbol Acetate	193-229	small proline rich protein 1B	Homo sapiens	66-72
12801607-7	2003	Furthermore, stimulation of PKC, using short-term 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment, markedly inhibited the stimulatory effects of EGF on Akt phosphorylation.	Tetradecanoylphorbol Acetate	50-86	epidermal growth factor	Homo sapiens	150-153
12801607-7	2003	Furthermore, stimulation of PKC, using short-term 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment, markedly inhibited the stimulatory effects of EGF on Akt phosphorylation.	Tetradecanoylphorbol Acetate	88-91	epidermal growth factor	Homo sapiens	150-153
12782578-9	2003	Psl2 maps near D2Mit229 on distal chromosome 2, and inheritance of the dominant DBA/2 allele results in increased sensitivity to TPA.	Tetradecanoylphorbol Acetate	129-132	promotion susceptibility QTL 2	Mus musculus	0-4
12787135-5	2003	E2 inhibited constitutive and 12-O-tetradecanoylphorbol-13-acetate-induced MCP-1 secretion, mRNA expression, and promoter activity in keratinocytes, and these effects of E2 were counteracted by estrogen receptor antagonist ICI 182 780.	Tetradecanoylphorbol Acetate	30-66	C-C motif chemokine ligand 2	Homo sapiens	75-80
12787135-6	2003	GC-rich Sp1 element and activator protein 1 (AP-1) element on MCP-1 promoter were required for constitutive and 12-O-tetradecanoylphorbol-13-acetate-induced transcription, respectively, and involved in transrepression by E2.	Tetradecanoylphorbol Acetate	112-148	C-C motif chemokine ligand 2	Homo sapiens	62-67
12790799-6	2003	PMA-mediated activation of PKC (100 nM; 4 h) reduced glucose/IGF-I mediated beta-cell mitogenesis (&gt;50%; P&lt; or =0.05), which was reversible by the general PKC inhibitor Go6850 (1 microM), indicating an effect of PKC and not due to a non-specific PMA toxicity.	Tetradecanoylphorbol Acetate	0-3	insulin-like growth factor 1	Rattus norvegicus	61-66
12790799-10	2003	Thus, FFA/PMA-induced activation of novel PKC isoforms can inhibit glucose/IGF-I-mediated beta-cell mitogenesis, in part by decreasing PKB activation, despite an upregulation of Erk1/2.	Tetradecanoylphorbol Acetate	10-13	insulin-like growth factor 1	Rattus norvegicus	75-80
12737946-9	2003	Genes for proteins whose upregulation requires hours of TPA exposure (the 4F2hc component of the L-system amino acid transporter, prohibition, and hsp60) were assessed, and their later expression contrasted with the early expression of EGR-1, dual specificity phosphatase 2, and CD69.	Tetradecanoylphorbol Acetate	56-59	solute carrier family 3 member 2	Homo sapiens	74-79
12737946-10	2003	EGR-1 encodes a zinc-finger transcription factor that is induced by pokeweed mitogen and TPA and promotes B lymphocyte maturation.	Tetradecanoylphorbol Acetate	89-92	early growth response 1	Homo sapiens	0-5
12709020-7	2003	Activation of T lymphocytes by phorbol 12-myristate 13-acetate/ionomycin resulted in markedly enhanced binding activities to the NF-AT site, which significantly increased upon addition of BPA or NP, as demonstrated by the electrophoretic mobility shift assay, indicating that the transcription factor NF-AT was involved in the enhancing effect of BPA and NP on IL-4 production.	Tetradecanoylphorbol Acetate	31-62	interleukin 4	Mus musculus	361-365
12750906-0	2003	ML-7 inhibits exocytosis of superoxide-producing intracellular compartments in human neutrophils stimulated with phorbol myristate acetate in a myosin light chain kinase-independent manner.	Tetradecanoylphorbol Acetate	113-138	solute carrier family 25 member 16	Homo sapiens	0-4
12750906-0	2003	ML-7 inhibits exocytosis of superoxide-producing intracellular compartments in human neutrophils stimulated with phorbol myristate acetate in a myosin light chain kinase-independent manner.	Tetradecanoylphorbol Acetate	113-138	myosin light chain kinase	Homo sapiens	144-169
12694408-3	2003	However, simultaneous forskolin and PMA treatment synergistically activated the PNMT promoter approximately four-fold, suggesting that PKC stimulation requires prior induction of the PKA pathway.	Tetradecanoylphorbol Acetate	36-39	phenylethanolamine-N-methyltransferase	Rattus norvegicus	80-84
12694408-3	2003	However, simultaneous forskolin and PMA treatment synergistically activated the PNMT promoter approximately four-fold, suggesting that PKC stimulation requires prior induction of the PKA pathway.	Tetradecanoylphorbol Acetate	36-39	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	183-186
12694408-4	2003	Consistent with this possibility the adenylate cyclase inhibitor MDL12,330A, and the PKA inhibitor H-89 prevented PNMT promoter stimulation by the combination of forskolin and PMA.	Tetradecanoylphorbol Acetate	176-179	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	85-88
12694408-4	2003	Consistent with this possibility the adenylate cyclase inhibitor MDL12,330A, and the PKA inhibitor H-89 prevented PNMT promoter stimulation by the combination of forskolin and PMA.	Tetradecanoylphorbol Acetate	176-179	phenylethanolamine-N-methyltransferase	Rattus norvegicus	114-118
12694807-8	2003	Furthermore, phorbol myristate acetate (PMA), a PKC stimulant, but not dibutyryl cyclic AMP, a protein kinase A stimulant, stimulated the accumulation of HSP27.	Tetradecanoylphorbol Acetate	13-38	heat shock protein family B (small) member 1	Homo sapiens	154-159
12694807-8	2003	Furthermore, phorbol myristate acetate (PMA), a PKC stimulant, but not dibutyryl cyclic AMP, a protein kinase A stimulant, stimulated the accumulation of HSP27.	Tetradecanoylphorbol Acetate	40-43	heat shock protein family B (small) member 1	Homo sapiens	154-159
12687017-2	2003	JDP2 represses transcriptional activation of reporter constructs containing 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive elements (TRE) or cyclic AMP responsive elements (CRE).	Tetradecanoylphorbol Acetate	76-112	Jun dimerization protein 2	Gallus gallus	0-4
12687017-2	2003	JDP2 represses transcriptional activation of reporter constructs containing 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive elements (TRE) or cyclic AMP responsive elements (CRE).	Tetradecanoylphorbol Acetate	114-117	Jun dimerization protein 2	Gallus gallus	0-4
12651935-2	2003	To examine this regulation at the signal transduction level, we treated cultured dental follicle cells with either phorbolmyristate acetate (PMA) or dibutyryl cyclic AMP (dbcAMP) to activate either protein kinase C (PKC) or protein kinase A (PKA).	Tetradecanoylphorbol Acetate	115-139	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	224-240
12651935-2	2003	To examine this regulation at the signal transduction level, we treated cultured dental follicle cells with either phorbolmyristate acetate (PMA) or dibutyryl cyclic AMP (dbcAMP) to activate either protein kinase C (PKC) or protein kinase A (PKA).	Tetradecanoylphorbol Acetate	115-139	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	242-245
12841345-3	2003	Increased levels of PAI-1 with various levels of tPA have been frequently found in plasma of patients with coronary heart disease (CHD) or diabetes mellitus (DM).	Tetradecanoylphorbol Acetate	49-52	serpin family E member 1	Homo sapiens	20-25
12646185-6	2003	Furthermore, this activity was enhanced by protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), in an ETS consensus-dependent manner, while PMA could also enhance the expression level of ETS2.	Tetradecanoylphorbol Acetate	71-102	ETS proto-oncogene 2, transcription factor	Homo sapiens	201-205
12646185-6	2003	Furthermore, this activity was enhanced by protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), in an ETS consensus-dependent manner, while PMA could also enhance the expression level of ETS2.	Tetradecanoylphorbol Acetate	104-107	ETS proto-oncogene 2, transcription factor	Homo sapiens	201-205
12586779-7	2003	In cultured granulosa cells, forskolin and phorbol 12 myristate 13-acetate or FSH + testosterone increased expression of versican.	Tetradecanoylphorbol Acetate	43-74	versican	Mus musculus	121-129
12468550-0	2003	New insights into the tPA-annexin A2 interaction.	Tetradecanoylphorbol Acetate	22-25	annexin A2	Homo sapiens	26-36
12468550-4	2003	The annexin A2 motif that mediates tissue plasminogen activator interaction has been assigned to the hexapeptide LCKLSL in the amino-terminal domain of the protein, and it has been proposed that Cys(8) of this sequence is essential for tPA binding.	Tetradecanoylphorbol Acetate	236-239	annexin A2	Homo sapiens	4-14
12468550-5	2003	In an attempt to identify other amino acids critical for tPA-annexin A2 interaction, we have analyzed a set of peptides containing several modifications of the original hexapeptide, including glycine scans, alanine scans, d-amino acid scans, conservative mutations, cysteine blocking, and enantiomer and retroenantiomer sequences.	Tetradecanoylphorbol Acetate	57-60	annexin A2	Homo sapiens	61-71
12468550-6	2003	Using a non-radioactive competitive binding assay, we have found that all cysteine-containing peptides, independently of their sequence, compete the interaction between tPA and annexin A2.	Tetradecanoylphorbol Acetate	169-172	annexin A2	Homo sapiens	177-187
12468550-9	2003	These data call for a revision of the role of the LCKLSL sequence as the sole annexin A2 structural region required to bind tPA and indicate that further studies are necessary to better define the annexin A2-tPA interaction.	Tetradecanoylphorbol Acetate	208-211	annexin A2	Homo sapiens	197-207
12592382-2	2003	Western blot of three activated forms of mitogen-activated protein kinase (MAPK) (p-ERK, p-JNK and p-p38) demonstrated that phosphorylation of ERK is dramatically induced (11.6-fold ) by TPA during 15 min to 1 h and significantly induced (2.5-fold) by Saikosaponin alpha at 30 min, whereas phosphorylation of JNK was induced only by TPA during 30 min to 1 h. Phosphorylation of p38 was not induced by either drug.	Tetradecanoylphorbol Acetate	187-190	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	82-87
12586343-7	2003	Phorbol-12-myristate-13-acetate significantly reduced the induction of apoptosis, inhibiting caspase 3 cleavage, Bax accumulation, Bcl-xL down-regulation as well as restoring cell viability.	Tetradecanoylphorbol Acetate	0-31	BCL2 associated X, apoptosis regulator	Rattus norvegicus	113-116
12581266-6	2003	RESULTS: The 56 incident cases of CAD had marginally lower PAI-1 and higher tPA-PAI-1 levels compared with those free of CAD.	Tetradecanoylphorbol Acetate	76-79	serpin family E member 1	Homo sapiens	80-85
12581266-7	2003	However, marginally higher PAI-1 and significantly higher tPA-PAI-1 (P = 0.04) levels were seen in those who developed nephropathy.	Tetradecanoylphorbol Acetate	58-61	serpin family E member 1	Homo sapiens	62-67
12581266-8	2003	After controlling for age, both PAI-1 and tPA-PAI-1 showed significant negative correlations with HDL-cholesterol, and positive correlations with triglycerides, WHR, HbA1 and fibrinogen.	Tetradecanoylphorbol Acetate	42-45	serpin family E member 1	Homo sapiens	46-51
12581266-9	2003	tPA-PAI-1 was also positively correlated with total and LDL-cholesterol.	Tetradecanoylphorbol Acetate	0-3	serpin family E member 1	Homo sapiens	4-9
12581266-12	2003	However, tPA-PAI-1 complexes may be involved in the pathogenesis of overt nephropathy.	Tetradecanoylphorbol Acetate	9-12	serpin family E member 1	Homo sapiens	13-18
12542530-3	2003	Irritant dermatitis was induced by applying phorbol 12-myristate-13-acetate (TPA) to the surface of the ears of CD1 mice, followed by treatment with 22ROH, 25OH, GW3965, or vehicle alone.	Tetradecanoylphorbol Acetate	44-75	CD1 antigen complex	Mus musculus	112-115
12542530-3	2003	Irritant dermatitis was induced by applying phorbol 12-myristate-13-acetate (TPA) to the surface of the ears of CD1 mice, followed by treatment with 22ROH, 25OH, GW3965, or vehicle alone.	Tetradecanoylphorbol Acetate	77-80	CD1 antigen complex	Mus musculus	112-115
12560508-5	2003	When BE(2)-M17 cells were treated with phorbol 12-myristate 13-acetate, we observed inducible expression and binding of the EGR-1 transcription factor to the two GC-boxes.	Tetradecanoylphorbol Acetate	39-70	early growth response 1	Homo sapiens	124-129
12419822-0	2003	Identification of Dss1 as a 12-O-tetradecanoylphorbol-13-acetate-responsive gene expressed in keratinocyte progenitor cells, with possible involvement in early skin tumorigenesis.	Tetradecanoylphorbol Acetate	28-64	SEM1 26S proteasome subunit	Homo sapiens	18-22
12419822-5	2003	cDNA microarray expression analysis showed that the mouse homologue of Dss1 is induced by TPA.	Tetradecanoylphorbol Acetate	90-93	SEM1 26S proteasome subunit	Homo sapiens	71-75
12419822-6	2003	Dss1 overexpression was detected by Northern blot analysis in early TPA-treated hyperplastic skins and in JB6 Cl 41-5a epidermal cells.	Tetradecanoylphorbol Acetate	68-71	SEM1 26S proteasome subunit	Homo sapiens	0-4
12419822-9	2003	These results strongly suggest that Dss1 is a TPA-inducible gene that may play an important role in the early stages of skin carcinogenesis.	Tetradecanoylphorbol Acetate	46-49	SEM1 26S proteasome subunit	Homo sapiens	36-40
12533598-6	2003	Pharmacological preconditioning with the nonselective PKC isozyme activator phorbol myristate acetate could not emulate IPC, but blockade of PKC activation with chelerythrine during IPC blocked its neuroprotection.	Tetradecanoylphorbol Acetate	76-101	protein kinase C epsilon	Homo sapiens	54-57
12388064-4	2003	Treatment of cells with PMA or L-PGDS decreased phosphatidylinositol 3-kinase (PI3-K) activity and concomitantly inhibited protein kinase B (PKB/Akt) phosphorylation, which led to the hypophosphorylation and activation of Bad.	Tetradecanoylphorbol Acetate	24-27	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	48-77
12388064-4	2003	Treatment of cells with PMA or L-PGDS decreased phosphatidylinositol 3-kinase (PI3-K) activity and concomitantly inhibited protein kinase B (PKB/Akt) phosphorylation, which led to the hypophosphorylation and activation of Bad.	Tetradecanoylphorbol Acetate	24-27	protein tyrosine kinase 2 beta	Homo sapiens	123-139
12788054-6	2003	In this study with hydrocortisone, calpain inhibitor (ALLN) and phorbol myristate acetate (PMA) treatments we demonstrate that apoptosis is inhibited as shown by [3H] thymidine incorporation studies, propidium iodide staining and Annexin V staining.	Tetradecanoylphorbol Acetate	64-89	annexin A5	Homo sapiens	230-239
12788054-6	2003	In this study with hydrocortisone, calpain inhibitor (ALLN) and phorbol myristate acetate (PMA) treatments we demonstrate that apoptosis is inhibited as shown by [3H] thymidine incorporation studies, propidium iodide staining and Annexin V staining.	Tetradecanoylphorbol Acetate	91-94	annexin A5	Homo sapiens	230-239
12477864-14	2003	A chromatin immunoprecipitation assay showed that all three proteins associated specifically with RAP promoter DNA in vivo and that, when C/EBPalpha was removed from a tetradecanoyl phorbol acetate-treated JSC-1 primary effusion lymphoma cell lysate, the levels of association of RTA and RAP with the RAP promoter were reduced 3- and 13-fold, respectively.	Tetradecanoylphorbol Acetate	168-197	LDL receptor related protein associated protein 1	Homo sapiens	288-291
12477864-14	2003	A chromatin immunoprecipitation assay showed that all three proteins associated specifically with RAP promoter DNA in vivo and that, when C/EBPalpha was removed from a tetradecanoyl phorbol acetate-treated JSC-1 primary effusion lymphoma cell lysate, the levels of association of RTA and RAP with the RAP promoter were reduced 3- and 13-fold, respectively.	Tetradecanoylphorbol Acetate	168-197	LDL receptor related protein associated protein 1	Homo sapiens	288-291
12482960-10	2003	Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a candidate substrate of Meltrin alpha, and we found that TPA (12-O-tetradecanoylphorbol-13-acetate)-induced ectodomain shedding of HB-EGF is markedly reduced in embryonic fibroblasts prepared from Meltrin alpha-deficient mice.	Tetradecanoylphorbol Acetate	129-132	heparin-binding EGF-like growth factor	Mus musculus	0-58
12482960-10	2003	Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a candidate substrate of Meltrin alpha, and we found that TPA (12-O-tetradecanoylphorbol-13-acetate)-induced ectodomain shedding of HB-EGF is markedly reduced in embryonic fibroblasts prepared from Meltrin alpha-deficient mice.	Tetradecanoylphorbol Acetate	129-132	heparin-binding EGF-like growth factor	Mus musculus	60-66
12482960-10	2003	Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a candidate substrate of Meltrin alpha, and we found that TPA (12-O-tetradecanoylphorbol-13-acetate)-induced ectodomain shedding of HB-EGF is markedly reduced in embryonic fibroblasts prepared from Meltrin alpha-deficient mice.	Tetradecanoylphorbol Acetate	129-132	heparin-binding EGF-like growth factor	Mus musculus	203-209
12482960-10	2003	Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a candidate substrate of Meltrin alpha, and we found that TPA (12-O-tetradecanoylphorbol-13-acetate)-induced ectodomain shedding of HB-EGF is markedly reduced in embryonic fibroblasts prepared from Meltrin alpha-deficient mice.	Tetradecanoylphorbol Acetate	134-170	heparin-binding EGF-like growth factor	Mus musculus	0-58
12482960-10	2003	Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a candidate substrate of Meltrin alpha, and we found that TPA (12-O-tetradecanoylphorbol-13-acetate)-induced ectodomain shedding of HB-EGF is markedly reduced in embryonic fibroblasts prepared from Meltrin alpha-deficient mice.	Tetradecanoylphorbol Acetate	134-170	heparin-binding EGF-like growth factor	Mus musculus	60-66
12482960-10	2003	Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a candidate substrate of Meltrin alpha, and we found that TPA (12-O-tetradecanoylphorbol-13-acetate)-induced ectodomain shedding of HB-EGF is markedly reduced in embryonic fibroblasts prepared from Meltrin alpha-deficient mice.	Tetradecanoylphorbol Acetate	134-170	heparin-binding EGF-like growth factor	Mus musculus	203-209
12699785-3	2003	Bath administration of the PKC activator phorbol-12-myristate 13-acetate (PMA), but not the inactive isomer 4alpha-PMA, significantly enhanced the NMDA-evoked inward current and electrically evoked excitatory postsynaptic currents.	Tetradecanoylphorbol Acetate	41-72	protein kinase C, gamma	Mus musculus	27-30
11961135-5	2002	Both 12-O-tetradecanoylphorbol-13 acetate (TPA) and forskolin increased the synthesis of Fn.	Tetradecanoylphorbol Acetate	5-41	fibronectin 1	Rattus norvegicus	89-91
11961135-5	2002	Both 12-O-tetradecanoylphorbol-13 acetate (TPA) and forskolin increased the synthesis of Fn.	Tetradecanoylphorbol Acetate	43-46	fibronectin 1	Rattus norvegicus	89-91
11961135-6	2002	However, the extracellular assembly of Fn fibril from both endogenously released and exogenously applied soluble Fn was increased by TPA but decreased by forskolin.	Tetradecanoylphorbol Acetate	133-136	fibronectin 1	Rattus norvegicus	39-41
11961135-6	2002	However, the extracellular assembly of Fn fibril from both endogenously released and exogenously applied soluble Fn was increased by TPA but decreased by forskolin.	Tetradecanoylphorbol Acetate	133-136	fibronectin 1	Rattus norvegicus	113-115
12006099-1	2002	The serine proteinases, tissue-type (tPA) and urokinase (uPA) plasminogen activator, are implicated in the ovulatory processes via their ability to convert plasminogen to its active form, plasmin.	Tetradecanoylphorbol Acetate	37-40	plasminogen activator, urokinase	Bos taurus	57-60
11884385-3	2002	In this study, direct phosphorylation of VR1 upon application of phorbol 12-myristate 13-acetate (PMA) was proven biochemically in cells expressing VR1.	Tetradecanoylphorbol Acetate	65-96	vault RNA 1-1	Homo sapiens	41-44
11884385-3	2002	In this study, direct phosphorylation of VR1 upon application of phorbol 12-myristate 13-acetate (PMA) was proven biochemically in cells expressing VR1.	Tetradecanoylphorbol Acetate	65-96	vault RNA 1-1	Homo sapiens	148-151
11884385-3	2002	In this study, direct phosphorylation of VR1 upon application of phorbol 12-myristate 13-acetate (PMA) was proven biochemically in cells expressing VR1.	Tetradecanoylphorbol Acetate	98-101	vault RNA 1-1	Homo sapiens	41-44
11884385-3	2002	In this study, direct phosphorylation of VR1 upon application of phorbol 12-myristate 13-acetate (PMA) was proven biochemically in cells expressing VR1.	Tetradecanoylphorbol Acetate	98-101	vault RNA 1-1	Homo sapiens	148-151
11956069-5	2002	The subsequent confirmation of the altered expression levels of the selected genes by semiquantitative reverse transcription-PCR demonstrated that overexpression of the antisense ING1 stimulated expression of 14 genes, which included cyclin B1, 12-O-tetradecanoylphorbol-13-acetate-inducible sequence 11, proto-oncogene DEK, and osteopontin, whereas we have detected transcriptional repression of 5 genes, including TPT1.	Tetradecanoylphorbol Acetate	245-281	tumor protein, translationally-controlled 1	Mus musculus	416-420
11920638-6	2002	TPA induced phosphorylation of MEK1/2 was also raised by OHT treatment, without any change in their protein level or Raf-1 and H-Ras levels.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 1	Homo sapiens	31-37
11953985-6	2002	Impaired shedding of TNFRSF1A after phorbol myristate acetate stimulation was detected in blood granulocytes and monocytes from the 3 adult family members with the mutation, but in the child bearing the mutation and showing clinical symptoms of recent onset, the shedding defect was less marked.	Tetradecanoylphorbol Acetate	36-61	TNF receptor superfamily member 1A	Homo sapiens	21-29
11897696-2	2002	We demonstrated that, as in alpha T(3)-1 cells, in a more differentiated gonadotrope cell line L beta T(2) the GnRH-receptor coupling (PLC, PLA2, PLD) generated second messengers essential for PKCs activation; the characterized isoforms (alpha, beta II, delta, epsilon, zeta) were selectively and differentially down-regulated by TPA (alpha, beta II, delta, epsilon) or GnRH (delta, epsilon).	Tetradecanoylphorbol Acetate	330-333	gonadotropin releasing hormone 1	Rattus norvegicus	111-115
11897696-3	2002	In whole cell lysates, proteasome inhibitors (proteasome inhibitor I and II, Lactacystin, beta-Lactone, Calpain inhibitor I) prevented in both gonadotrope cell lines the TPA-induced depletion of PKC alpha, epsilon, and the GnRH-elicited PKC epsilon down-regulation; they counteracted in mixed pituitary cell cultures as well, the TPA-evoked PKC alpha, epsilon depletion.	Tetradecanoylphorbol Acetate	170-173	gonadotropin releasing hormone 1	Rattus norvegicus	223-227
12042071-9	2002	Okadaic acid and phorbol 12-myristate 13-acetate significantly decreased heme-mediated induction of heme oxygenase-1 mRNA in both Huh-7 and HepG2 cells.	Tetradecanoylphorbol Acetate	17-48	heme oxygenase 1	Homo sapiens	100-116
11960350-6	2002	Pretreatment of cells with 5 microM of the MEK-1/-2-specific inhibitor U0126 abrogated PMA- or RA-induced activation of ERK-1/MAPK and ERK-2/MAPK.	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase kinase 1	Homo sapiens	43-51
11799119-1	2002	The phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent stimulator of Erk, leads to the phosphorylation of 4E-BP1 and its dissociation from eIF4E.	Tetradecanoylphorbol Acetate	19-55	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	123-129
11799119-1	2002	The phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent stimulator of Erk, leads to the phosphorylation of 4E-BP1 and its dissociation from eIF4E.	Tetradecanoylphorbol Acetate	57-60	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	123-129
11799119-3	2002	In this report, we investigate the mechanism by which TPA regulates 4E-BP1 phosphorylation.	Tetradecanoylphorbol Acetate	54-57	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	68-74
11799119-4	2002	Treatment of HEK293 cells with TPA was found to result in the phosphorylation of 4E-BP1 at Ser(64), Thr(69), and Thr(36/45).	Tetradecanoylphorbol Acetate	31-34	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	81-87
11864993-7	2002	A mechanism whereby PKC alpha might regulate hypertrophy was suggested by the observations that wild-type PKC alpha induced extracellular signal-regulated kinase1/2 (ERK1/2), that dominant negative PKC alpha inhibited PMA-induced ERK1/2 activation, and that dominant negative MEK1 (up-stream of ERK1/2) inhibited wild-type PKC alpha-induced hypertrophic growth.	Tetradecanoylphorbol Acetate	218-221	mitogen-activated protein kinase kinase 1	Homo sapiens	276-280
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	33-36	insulin-like growth factor binding protein 5	Rattus norvegicus	227-234
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	33-36	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	295-311
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	33-36	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	313-316
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	33-36	insulin-like growth factor binding protein 5	Rattus norvegicus	340-347
11896487-9	2002	PMA also induced a significant translocation of ventricular GLUT-4 from the microsomal to the sarcolemmal fraction within 60 min in lean but not in obese rats.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 2 member 4	Rattus norvegicus	60-66
11875115-6	2002	Epidermal growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate, and okadaic acid, other agents that cause serine/threonine phosphorylation of IRS-1, also stimulated IRS binding to 14-3-3.	Tetradecanoylphorbol Acetate	31-67	insulin receptor substrate 1	Homo sapiens	147-152
11861425-4	2002	Northern and Western blot analyses showed that exposure of THP-1 cells to PMA (phorbol 12-myristate 13-acetate) increases OPN mRNA and protein levels in a time-dependent manner.	Tetradecanoylphorbol Acetate	79-110	secreted phosphoprotein 1	Homo sapiens	122-125
11834706-2	2002	In neutrophils, the p47(phox) subunit is centrally involved in oxidase activation in response to agonists such as phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	114-145	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	20-29
11834706-2	2002	In neutrophils, the p47(phox) subunit is centrally involved in oxidase activation in response to agonists such as phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	147-150	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	20-29
12699785-3	2003	Bath administration of the PKC activator phorbol-12-myristate 13-acetate (PMA), but not the inactive isomer 4alpha-PMA, significantly enhanced the NMDA-evoked inward current and electrically evoked excitatory postsynaptic currents.	Tetradecanoylphorbol Acetate	74-77	protein kinase C, gamma	Mus musculus	27-30
12699785-4	2003	Chelerythrine, a selective blocker of PKC, completely prevented the potentiating action produced by either clozapine or PMA on these currents in the mPFC cells.	Tetradecanoylphorbol Acetate	120-123	protein kinase C, gamma	Mus musculus	38-41
14976916-3	2003	Significant direct correlations--uPA vs. VEGF, uPA vs. PAI-1 and PAI-1 vs. VEGF--were established in endometrial tumors, and inverse ones for tPA vs. uPA and tPA vs. VEGF.	Tetradecanoylphorbol Acetate	142-145	serpin family E member 1	Homo sapiens	65-70
12433834-12	2002	Our results demonstrate that the two transcription factors, Egr-1 and AP-1, are involved in the PMA-induced ACE transcriptional activation in human endothelial cells via the activation of the extracellular signal-regulated kinase 1/2 signaling pathway.	Tetradecanoylphorbol Acetate	96-99	early growth response 1	Homo sapiens	60-65
12372816-2	2002	We recently showed that the phorbol ester PMA (100 nM) induces prompt activation of the novel isoform PKCepsilon followed by late activation of the conventional isoform PKCalpha in T84 intestinal epithelia.	Tetradecanoylphorbol Acetate	42-45	protein kinase C epsilon	Homo sapiens	102-112
27409835-0	2016	Deletion of 14-3-3sigma sensitizes mice to DMBA/TPA-induced papillomatosis.	Tetradecanoylphorbol Acetate	48-51	stratifin	Homo sapiens	12-23
12091396-0	2002	The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion.	Tetradecanoylphorbol Acetate	26-57	RAP1A, member of RAS oncogene family	Homo sapiens	11-15
11792626-9	2002	Interestingly, unlike in S6 cells, a catalytically inactive c-Jun NH(2)-terminal kinase (JNK) 1 mutant significantly reduced the PMA-inducible SPRR1B promoter activity in H441 cells.	Tetradecanoylphorbol Acetate	129-132	small proline rich protein 1B	Homo sapiens	143-149
27409835-8	2016	Deletion of 14-3-3sigma did not enhance spontaneous epidermal tumor development, whereas it increased the frequency and size of DMBA/TPA-induced papillomas.	Tetradecanoylphorbol Acetate	133-136	stratifin	Homo sapiens	12-23
12354938-1	2002	AIMS: To establish whether the MYB protein expressed in HL-60 variant cells, which are cells resistant to 12-O-tetradecanoylphorbol-13-acetate (TPA) induced differentiation, is able to bind MYB recognition elements (MREs) involved in the transcriptional regulation of myb target genes.	Tetradecanoylphorbol Acetate	106-142	MYB proto-oncogene, transcription factor	Homo sapiens	31-34
27240266-2	2016	By applying this principle, we have developed a stable Pt1 single-atom catalyst with a high Pt loading (close to 1 wt %) on phosphomolybdic acid(PMA)-modified active carbon.	Tetradecanoylphorbol Acetate	145-148	zinc finger protein 77	Homo sapiens	55-58
12270146-5	2002	Sustained activation of the MEK1-ERK1/2 pathway is generated in the membrane skeleton by continuous cell adhesion and seems to be essential to TPA-induced megakaryocytic differentiation of CMK cells.	Tetradecanoylphorbol Acetate	143-146	mitogen-activated protein kinase kinase 1	Homo sapiens	28-32
12082101-8	2002	The overexpression of MEK1 enhanced substantially junD expression in response to UV or TPA.	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase kinase 1	Homo sapiens	22-26
12082101-9	2002	In contrast, the suppression of Erk activation with PD98059, a specific inhibitor of MEK1, inhibited UV- and TPA-induced junD mRNA expression, UV-induced increases in caspase-3 activities, and cell death.	Tetradecanoylphorbol Acetate	109-112	mitogen-activated protein kinase kinase 1	Homo sapiens	85-89
11830549-4	2002	The level of MCL1 protein was 5-fold elevated compared with ML-1 cells expressing maximal MCL1 on exposure to phorbol-12-myristate-13- acetate.	Tetradecanoylphorbol Acetate	110-142	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	13-17
11830549-4	2002	The level of MCL1 protein was 5-fold elevated compared with ML-1 cells expressing maximal MCL1 on exposure to phorbol-12-myristate-13- acetate.	Tetradecanoylphorbol Acetate	110-142	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	90-94
11809807-13	2002	Furthermore, RhoH is dramatically down regulated after phorbol myristate acetate treatment and in Th1 cells after activation by anti-CD3.	Tetradecanoylphorbol Acetate	55-80	ras homolog family member H	Homo sapiens	13-17
11809859-4	2002	In C9 cells, phorbol-12-myristate-13-acetate (PMA) caused much greater phosphorylation of Pyk2 and ERK than the Ca(2+) ionophore ionomycin, and the effects of PMA and Ang II were abolished in PKC-depleted cells.	Tetradecanoylphorbol Acetate	13-44	protein tyrosine kinase 2 beta	Homo sapiens	90-94
11809859-4	2002	In C9 cells, phorbol-12-myristate-13-acetate (PMA) caused much greater phosphorylation of Pyk2 and ERK than the Ca(2+) ionophore ionomycin, and the effects of PMA and Ang II were abolished in PKC-depleted cells.	Tetradecanoylphorbol Acetate	13-44	EPH receptor B2	Homo sapiens	99-102
11809859-4	2002	In C9 cells, phorbol-12-myristate-13-acetate (PMA) caused much greater phosphorylation of Pyk2 and ERK than the Ca(2+) ionophore ionomycin, and the effects of PMA and Ang II were abolished in PKC-depleted cells.	Tetradecanoylphorbol Acetate	46-49	protein tyrosine kinase 2 beta	Homo sapiens	90-94
11809859-4	2002	In C9 cells, phorbol-12-myristate-13-acetate (PMA) caused much greater phosphorylation of Pyk2 and ERK than the Ca(2+) ionophore ionomycin, and the effects of PMA and Ang II were abolished in PKC-depleted cells.	Tetradecanoylphorbol Acetate	46-49	EPH receptor B2	Homo sapiens	99-102
12198164-2	2002	Here we show that the mouse tetradecanoyl phorbol acetate induced sequence 7 (TIS7) protein is a novel transcriptional co-repressor that can associate with the SIN3 complex.	Tetradecanoylphorbol Acetate	28-57	interferon-related developmental regulator 1	Mus musculus	78-82
27222146-5	2016	Further experiments to determine the mechanism responsible for the inhibitory effects of RbAp48 revealed that the ectopic expression of RbAp48 repressed HIV-1 long terminal repeat (LTR)-mediated basal transcription as well as TNF-alpha- and phorbol 12-myristate 13-acetate (PMA)-activated transcription.	Tetradecanoylphorbol Acetate	241-272	RB binding protein 4, chromatin remodeling factor	Homo sapiens	136-142
12205041-6	2002	Inhibition of PKC by GF109203x or MEK1/2 by U0126 (or PD98059) abolished the 5-LO up-regulation effects of PMA.	Tetradecanoylphorbol Acetate	107-110	mitogen-activated protein kinase kinase 1	Homo sapiens	34-40
12009309-1	2002	BACKGROUND AND AIMS: The expression of osteopontin (OPN), a protein postulated to play a role in tumorigenesis, is induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) in vivo and in the in vitro initiation-promotion skin carcinogenesis model (JB6 cells).	Tetradecanoylphorbol Acetate	146-182	secreted phosphoprotein 1	Homo sapiens	39-50
12009309-1	2002	BACKGROUND AND AIMS: The expression of osteopontin (OPN), a protein postulated to play a role in tumorigenesis, is induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) in vivo and in the in vitro initiation-promotion skin carcinogenesis model (JB6 cells).	Tetradecanoylphorbol Acetate	146-182	secreted phosphoprotein 1	Homo sapiens	52-55
12009309-1	2002	BACKGROUND AND AIMS: The expression of osteopontin (OPN), a protein postulated to play a role in tumorigenesis, is induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) in vivo and in the in vitro initiation-promotion skin carcinogenesis model (JB6 cells).	Tetradecanoylphorbol Acetate	184-187	secreted phosphoprotein 1	Homo sapiens	39-50
12009309-1	2002	BACKGROUND AND AIMS: The expression of osteopontin (OPN), a protein postulated to play a role in tumorigenesis, is induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) in vivo and in the in vitro initiation-promotion skin carcinogenesis model (JB6 cells).	Tetradecanoylphorbol Acetate	184-187	secreted phosphoprotein 1	Homo sapiens	52-55
12009309-2	2002	Although TPA-induced OPN expression in JB6 cells has been suggested to involve protein kinase C (PKC), the PKC isoforms and the downstream pathway mediating OPN expression have not been extensively studied.	Tetradecanoylphorbol Acetate	9-12	secreted phosphoprotein 1	Homo sapiens	21-24
27222146-5	2016	Further experiments to determine the mechanism responsible for the inhibitory effects of RbAp48 revealed that the ectopic expression of RbAp48 repressed HIV-1 long terminal repeat (LTR)-mediated basal transcription as well as TNF-alpha- and phorbol 12-myristate 13-acetate (PMA)-activated transcription.	Tetradecanoylphorbol Acetate	274-277	RB binding protein 4, chromatin remodeling factor	Homo sapiens	136-142
12009309-3	2002	METHODS: Using the JB6 cell model, we determined the involvement of PKC isoforms, mitogen-activated protein kinase kinase (MAPK kinase/MEK) and MAPK in TPA-induced OPN expression using inhibitors specific to PKC isoforms and MEK and performing Northern blot analyses.	Tetradecanoylphorbol Acetate	152-155	secreted phosphoprotein 1	Homo sapiens	164-167
12009309-5	2002	KEY RESULTS: TPA increased the steady-state level of OPN mRNA as early as 2-4h and this expression persisted for at least 4 days.	Tetradecanoylphorbol Acetate	13-16	secreted phosphoprotein 1	Homo sapiens	53-56
11840342-8	2002	TPA causes positive regulation of Cyr61 expression in ER-positive MCF-7 cells.	Tetradecanoylphorbol Acetate	0-3	cellular communication network factor 1	Homo sapiens	34-39
27163640-9	2016	The long-term TPA treatment induced the high cell motile activity and elevated GPR120 and GPR40 expressions.	Tetradecanoylphorbol Acetate	14-17	free fatty acid receptor 1	Homo sapiens	90-95
12009309-6	2002	TPA induction of OPN expression in JB6 cells is mediated through PKC epsilon and PKC delta, which also mediated the phosphorylation of MAPK.	Tetradecanoylphorbol Acetate	0-3	secreted phosphoprotein 1	Homo sapiens	17-20
12009309-6	2002	TPA induction of OPN expression in JB6 cells is mediated through PKC epsilon and PKC delta, which also mediated the phosphorylation of MAPK.	Tetradecanoylphorbol Acetate	0-3	protein kinase C epsilon	Homo sapiens	65-76
27163640-11	2016	These results suggest that GPR120 negatively and GPR40 positively regulate cell motile activities induce by TPA in melanoma cells.	Tetradecanoylphorbol Acetate	108-111	free fatty acid receptor 1	Homo sapiens	49-54
12009309-7	2002	Additionally, inhibition of MEK activity, which activates MAPK, attenuated TPA-induced OPN expression.	Tetradecanoylphorbol Acetate	75-78	secreted phosphoprotein 1	Homo sapiens	87-90
27039668-10	2016	EBV+ T/NK-cell line cells treated with phorbol 12-myristate 13-acetate produced BZLF1 and BDRF1 mRNA, and encapsidated EBV DNA was detected in the culture supernatants of cell line cells.	Tetradecanoylphorbol Acetate	39-70	protein Zta	Human gammaherpesvirus 4	80-85
12009309-9	2002	CONCLUSION: TPA-induced steady-state OPN mRNA expression in mouse JB6 cells involves the activation of MAPK mediated through PKC epsilon and/or PKC delta.	Tetradecanoylphorbol Acetate	12-15	protein kinase C epsilon	Homo sapiens	125-136
12231177-4	2002	Activation of protein kinase C in CD34(+) cells with the phorbol ester PMA (phorbol 12-myristate 13-acetate) increased the mRNA level of the GALV receptor (GLVR1) and the transduction efficiency (TE), and fully reversed the inhibition of transduction seen with high-titer GALV VCM.	Tetradecanoylphorbol Acetate	76-107	solute carrier family 20 member 1	Homo sapiens	156-161
11711529-6	2002	MEG2 activity, as determined by immunoprecipitation and in vitro phosphatase assays, is inhibited after exposure of cells to the particulate stimulant opsonized zymosan or to phorbol 12-myristate 13-acetate but largely unaffected by the chemoattractant N-formyl-methionyl-leucyl-phenyalanine.	Tetradecanoylphorbol Acetate	175-206	protein tyrosine phosphatase non-receptor type 9	Homo sapiens	0-4
11706008-3	2002	Treatment of naive lymphocytes with phorbol myristate acetate (PMA) induces rapid ectodomain proteolytic down-regulation (shedding) of surface L-selectin via a protein kinase C (PKC)-dependent pathway.	Tetradecanoylphorbol Acetate	36-61	selectin L	Homo sapiens	143-153
11706008-3	2002	Treatment of naive lymphocytes with phorbol myristate acetate (PMA) induces rapid ectodomain proteolytic down-regulation (shedding) of surface L-selectin via a protein kinase C (PKC)-dependent pathway.	Tetradecanoylphorbol Acetate	63-66	selectin L	Homo sapiens	143-153
27020455-0	2016	Phorbol myristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression.	Tetradecanoylphorbol Acetate	0-25	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	Homo sapiens	86-92
11928811-9	2002	These results indicate that in the FN remodeling process, occurring during FRT epithelium maturation, both plasmin-dependent (tPA activated) and plasmin-independent proteolytic activities are involved.	Tetradecanoylphorbol Acetate	126-129	fibronectin 1	Rattus norvegicus	35-37
12110518-6	2002	Proton extrusion capacity of ATP1AL1-transfected cells is drastically reduced after phorbol 12-myristate 13-acetate incubation and can be prevented with the PKC blocker bisindolylmaleimide.	Tetradecanoylphorbol Acetate	84-115	ATPase H+/K+ transporting non-gastric alpha2 subunit	Homo sapiens	29-36
12121572-4	2002	The involvement of PKC in NOX5 activation was investigated using myristate acetate (PMA), and the PKC inhibitor GF-109203X.	Tetradecanoylphorbol Acetate	84-87	NADPH oxidase 5	Homo sapiens	26-30
11782362-3	2002	In this study, we used inhibitors of Rsk-2 and MSK1 to decide which of these kinases was responsible for the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation of H3 in 10T(1/2) and Ciras-3 (H-ras-transformed 10T(1/2)) mouse fibroblasts.	Tetradecanoylphorbol Acetate	109-145	ribosomal protein S6 kinase polypeptide 3	Mus musculus	37-42
11782362-3	2002	In this study, we used inhibitors of Rsk-2 and MSK1 to decide which of these kinases was responsible for the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation of H3 in 10T(1/2) and Ciras-3 (H-ras-transformed 10T(1/2)) mouse fibroblasts.	Tetradecanoylphorbol Acetate	147-150	ribosomal protein S6 kinase polypeptide 3	Mus musculus	37-42
26961870-6	2016	Shedding of IL-23R was induced by stimulation with the phorbol ester phorbol 12-myristate 13-acetate (PMA), but not by ionomycin.	Tetradecanoylphorbol Acetate	69-100	interleukin 23 receptor	Homo sapiens	12-18
11782362-6	2002	H89, a potent MSK1 inhibitor, prevented TPA induction of H3 phosphorylation and diminished the TPA-induced expression of the c-fos and urokinase plasminogen activator genes.	Tetradecanoylphorbol Acetate	95-98	FBJ osteosarcoma oncogene	Mus musculus	125-130
12138205-10	2002	This mutated form of Cot also acts as a dominant negative for T-cell antigen receptor/CD28- or Akt/phorbol myristate acetate-induced NF-kappa B induction, while having relatively little effect on tumor necrosis factor induction of NF-kappa B.	Tetradecanoylphorbol Acetate	99-124	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	21-24
12091247-2	2002	We have recently shown that phorbol 13-myristate 12-acetate (PMA)-stimulated SPRR1B transcription in Clara-like H441 cells is mainly mediated by activator protein-1 (AP-1) and c-Jun N-terminal kinase-1 (JNK1).	Tetradecanoylphorbol Acetate	61-64	small proline rich protein 1B	Homo sapiens	77-83
11940578-5	2002	Thr-421/Ser-424 phosphorylation of S6K1 was observed predominantly in TPA-treated cells.	Tetradecanoylphorbol Acetate	70-73	ribosomal protein S6 kinase B1	Homo sapiens	35-39
26961870-6	2016	Shedding of IL-23R was induced by stimulation with the phorbol ester phorbol 12-myristate 13-acetate (PMA), but not by ionomycin.	Tetradecanoylphorbol Acetate	102-105	interleukin 23 receptor	Homo sapiens	12-18
11940578-6	2002	Dominant negative c-Raf expression or a MEK1/2 inhibitor (U0126) treatment showed a profound blocking effect only on the TPA-stimulated phosphorylation of S6K1 and mTOR.	Tetradecanoylphorbol Acetate	121-124	mitogen-activated protein kinase kinase 1	Homo sapiens	40-46
11940578-6	2002	Dominant negative c-Raf expression or a MEK1/2 inhibitor (U0126) treatment showed a profound blocking effect only on the TPA-stimulated phosphorylation of S6K1 and mTOR.	Tetradecanoylphorbol Acetate	121-124	ribosomal protein S6 kinase B1	Homo sapiens	155-159
26013710-6	2016	These mice also exhibited significantly reduced epidermal proliferation in response to TPA treatment that again correlated with reduced levels of cell cycle regulators and increased levels of p53 and p21.	Tetradecanoylphorbol Acetate	87-90	transformation related protein 53, pseudogene	Mus musculus	192-195
11940578-7	2002	Whereas p38 MAPK inhibitors exhibited only partial effect, MAPK-phosphatase-3 expression significantly blocked the TPA-stimulated S6K1 and mTOR phosphorylation.	Tetradecanoylphorbol Acetate	115-118	ribosomal protein S6 kinase B1	Homo sapiens	130-134
12082614-5	2002	Glucocorticoids, which exhibit potent anti-inflammatory and anti-tumor promoting activities repressed TPA-mediated S100A8 and S100A9 induction in wild type, but not in c-fos(-/-) mice, thus identifying both genes as the first examples of AP-1 target genes whose repression of TPA-induced transcription by glucocorticoids depends on c-Fos.	Tetradecanoylphorbol Acetate	102-105	FBJ osteosarcoma oncogene	Mus musculus	332-337
11849318-4	2002	Chloroquine partially reduced production of soluble p55 and p75 TNF receptors in cells stimulated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	103-134	TNF receptor superfamily member 1A	Homo sapiens	52-55
11849318-4	2002	Chloroquine partially reduced production of soluble p55 and p75 TNF receptors in cells stimulated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	136-139	TNF receptor superfamily member 1A	Homo sapiens	52-55
11773315-7	2002	PMA at 10 nM exhibited a similar uncoupling effect on the response of the endogenous opiate receptor to the agonist D-alanine-5-leucine-enkephalin (DADLE) in wild-type and T149A mutant-expressing clones.	Tetradecanoylphorbol Acetate	0-3	proenkephalin	Rattus norvegicus	136-146
27123161-6	2016	In addition, Apo-9"-fucoxanthinone inhibited the expression of interleukin-4, interferon-gamma and tumor necrosis factor-alpha by phorbol 12-myristate 13-acetate and ionomycin-stimulated lymphocytes.	Tetradecanoylphorbol Acetate	130-161	interleukin 4	Mus musculus	63-76
11734301-3	2002	However, recent reports have clarified that early growth response 1 gene (Egr1) positively regulates MDR1 transcription, while Wilms" tumor suppressor gene (WT1) does negative regulation of MDR1 gene expression in 12-O-tetradecanoylphorbol-13-acetate treated K562 cells.	Tetradecanoylphorbol Acetate	214-250	early growth response 1	Homo sapiens	44-67
11734301-3	2002	However, recent reports have clarified that early growth response 1 gene (Egr1) positively regulates MDR1 transcription, while Wilms" tumor suppressor gene (WT1) does negative regulation of MDR1 gene expression in 12-O-tetradecanoylphorbol-13-acetate treated K562 cells.	Tetradecanoylphorbol Acetate	214-250	early growth response 1	Homo sapiens	74-78
12006974-4	2002	Ectopic T-bet expression strongly increased IFN-gamma production in T(H)2 cells activated by PMA-ionomycin, but weakly increased IFN-gamma production in T(H)2 cells stimulated by IL-12 IL-18 or OVA peptide antigen-presenting cell stimulation.	Tetradecanoylphorbol Acetate	93-96	T-box transcription factor 21	Homo sapiens	8-13
12054499-4	2002	Signaling cascade studies indicated that both FGF-2 and TPA induced Ras activation, c-Raf phosphorylation, mitogen-activated protein kinase/ERK kinase (MEK(1/2)) phosphorylation, and extracellular signal-regulated kinase (ERK(1/2)) phosphorylation.	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase kinase 1	Homo sapiens	140-159
12054499-5	2002	The FGF-2- and TPA-induced MMP-9 secretion was significantly inhibited by transient transfection of MCF-7 cells with dominant negative Ras (Ras-N17) and by treatment with MEK(1/2) inhibitor PD98059.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase kinase 1	Homo sapiens	171-178
11880376-3	2002	Wild-type neuroserpin formed SDS-stable complexes with tPA with an association rate constant and K(i) of 1.2 x 10(4) m(-1) s(-1) and 5.8 nm, respectively.	Tetradecanoylphorbol Acetate	55-58	serpin family I member 1	Homo sapiens	10-21
26786102-3	2016	Here we show that androgens (5alpha-dihydrotestosterone and R1881) suppress c-Fos protein and mRNA expression induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) or EGF in human prostate cancer (PCa) cell lines.	Tetradecanoylphorbol Acetate	159-162	epidermal growth factor	Homo sapiens	167-170
11884403-7	2002	Protein kinase C inhibitors blocked phorbol myristate acetate-induced and spontaneous shedding of IL-6R resulting in the absence of sIL-6R in the culture medium, which in turn also prevented the activation of gp130.	Tetradecanoylphorbol Acetate	36-61	interleukin 6 cytokine family signal transducer	Homo sapiens	209-214
11934475-7	2002	In contrast, the strong inhibitory effect on dendritic growth by the PKC activator phorbol-12-myristate-13-acetate (PMA) did not require the presence of the PKCgamma isoform since it was still present in the cultures of PKCgamma-deficient mice.	Tetradecanoylphorbol Acetate	83-114	protein kinase C, gamma	Mus musculus	69-72
26542395-6	2016	Currents demonstrated outward rectification and reversal at 0 mV (properties consistent with TMEM16A) and were inhibited by either molecular (siRNA) or pharmacologic (PMA or Go6976) inhibition of PKCalpha.	Tetradecanoylphorbol Acetate	167-170	anoctamin 1	Homo sapiens	93-100
11739292-6	2001	Exposure to the PKC activator, PMA (150 nmol/L), increased the transport activity of only the AE3fl isoform by 50+/-11% (P&lt;0.05, n=6), consistent with the increase observed in intact myocardium.	Tetradecanoylphorbol Acetate	31-34	protein kinase C epsilon	Homo sapiens	16-19
11739292-8	2001	PKC inhibition by chelerythrine (10 micromol/L) blocked the PMA effect.	Tetradecanoylphorbol Acetate	60-63	protein kinase C epsilon	Homo sapiens	0-3
11728381-10	2001	These studies demonstrate that TPA initiates protein kinase C-dependent, ERK-independent processes that suppress CYP1A1 activation by TCDD in MCF10A-Neo cells.	Tetradecanoylphorbol Acetate	31-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	113-119
12074974-6	2002	The enzymatic activities of COX-1 and -2 are inhibited by resveratrol in cell-free models, and COX-2 mRNA and TPA-induced activation of protein kinase C and AP-1-mediated gene expression are suppressed by resveratrol in mammary epithelial cells.	Tetradecanoylphorbol Acetate	110-113	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	28-40
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	41-72	solute carrier organic anion transporter family member 1B1	Homo sapiens	171-178
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	41-72	solute carrier organic anion transporter family member 2B1	Homo sapiens	180-187
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	41-72	BCR pseudogene 1	Homo sapiens	368-372
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	74-77	solute carrier organic anion transporter family member 1B1	Homo sapiens	171-178
11719466-10	2001	Taken together, this study shows that a PKC-epsilon-Raf-1-MEK-ERK-AP1 signaling cascade acts on a 12-O-tetradecanoylphorbol-13-acetate response element-like element to mediate hypoxia-induced GRP78 expression in human gastric cancer cells.	Tetradecanoylphorbol Acetate	98-134	protein kinase C epsilon	Homo sapiens	40-51
11719467-8	2001	A positive regulatory mechanism for TGFbetaRII expression in a TGF-beta-expressing cell line was also investigated, and a TPA-responsive element (TRE)-like motif, TRE2, was detected in addition to the previously reported TRE-like motif Y element in the positive regulatory region.	Tetradecanoylphorbol Acetate	122-125	ubiquitin specific peptidase 6	Homo sapiens	163-167
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	74-77	solute carrier organic anion transporter family member 2B1	Homo sapiens	180-187
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	74-77	BCR pseudogene 1	Homo sapiens	368-372
26428848-4	2015	It is possible that U73122 blocked PMA-induced adhesion of U937 cells partially by down regulation and inactivation of both Pyk2 and paxillin signaling.	Tetradecanoylphorbol Acetate	35-38	protein tyrosine kinase 2 beta	Homo sapiens	124-128
11731087-4	2001	In LNCap cells, TNF-alpha, TPA, and butyrate reduced the activity as well as the level of GGT total mRNA.	Tetradecanoylphorbol Acetate	27-30	gamma-glutamyltransferase light chain family member 3	Homo sapiens	90-93
11731087-5	2001	In HeLa cells no significant changes were observed either in activity or in mRNA level whereas TPA induced both GGT activity and mRNA levels in U937 cells.	Tetradecanoylphorbol Acetate	95-98	gamma-glutamyltransferase light chain family member 3	Homo sapiens	112-115
11731087-7	2001	The GGT mRNA subtypes were also differently modulated in these cells after TNF-alpha, TPA or butyrate treatment, suggesting that they are regulated by distinct and cell type specific mechanisms.	Tetradecanoylphorbol Acetate	86-89	gamma-glutamyltransferase light chain family member 3	Homo sapiens	4-7
26319521-5	2015	At the same time, the results showed that infected mouse splenic NK cells expressed increased levels of CD25 and CD69 and produced more IL-2, IL-4, and IL-17 and less IFN-gamma after stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	200-203	interleukin 2	Mus musculus	136-140
11742143-3	2001	Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tPA and uPA activity, and is expressed in corresponding brain areas.	Tetradecanoylphorbol Acetate	70-73	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	0-33
26319521-5	2015	At the same time, the results showed that infected mouse splenic NK cells expressed increased levels of CD25 and CD69 and produced more IL-2, IL-4, and IL-17 and less IFN-gamma after stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	200-203	interleukin 4	Mus musculus	142-146
11742143-3	2001	Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tPA and uPA activity, and is expressed in corresponding brain areas.	Tetradecanoylphorbol Acetate	70-73	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	35-40
26608825-5	2015	In HT1080 cells, TSG101 depletion increased both baseline and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion through enhancing MMP-9 mRNA expression, but did not affect the expression or activation of MMP-2.	Tetradecanoylphorbol Acetate	62-93	tumor susceptibility 101	Homo sapiens	17-23
11747624-0	2001	Regulation of lymphotoxin-beta by tumor necrosis factor, phorbol myristate acetate, and ionomycin in Jurkat T cells.	Tetradecanoylphorbol Acetate	57-82	lymphotoxin beta	Homo sapiens	14-30
26608825-5	2015	In HT1080 cells, TSG101 depletion increased both baseline and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion through enhancing MMP-9 mRNA expression, but did not affect the expression or activation of MMP-2.	Tetradecanoylphorbol Acetate	95-98	tumor susceptibility 101	Homo sapiens	17-23
26459397-9	2015	In conclusion, repeated intra-nigrostriatal treatment with PMA induced microglial senescence with increased expression levels of beta-galactosidase and p21 in the substantia nigra of the rats.	Tetradecanoylphorbol Acetate	59-62	galactosidase, beta 1	Rattus norvegicus	129-147
11710520-8	2001	Up-regulation of protein kinase C by a 2 h preincubation with phorbol 12-myristate 13-acetate increased the EA4-dependent expression of the Cyp1a1 gene.	Tetradecanoylphorbol Acetate	62-93	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	140-146
11704829-10	2001	Mda-7 expression is also induced during megakaryocyte differentiation induced in human hematopoietic cells by treatment with TPA (12-O-tetradecanoyl phorbol-13-acetate).	Tetradecanoylphorbol Acetate	125-128	interleukin 24	Homo sapiens	0-5
11704829-10	2001	Mda-7 expression is also induced during megakaryocyte differentiation induced in human hematopoietic cells by treatment with TPA (12-O-tetradecanoyl phorbol-13-acetate).	Tetradecanoylphorbol Acetate	130-167	interleukin 24	Homo sapiens	0-5
26486958-9	2015	Transcript destabilization by TTP was nullified upon cellular activation by TPA/A23187, an effect dependent on MEK1/2 activity.	Tetradecanoylphorbol Acetate	76-79	mitogen-activated protein kinase kinase 1	Homo sapiens	111-117
26343458-0	2015	Role of a TPA-responsive element in hepcidin transcription induced by the bone morphogenetic protein pathway.	Tetradecanoylphorbol Acetate	10-13	hepcidin antimicrobial peptide	Homo sapiens	36-44
11597569-6	2001	In contrast, stimulation of protein kinase C activity (100 nM phorbol 12-myristate 13-acetate) attenuated PGE2-induced adenylyl cyclase activity and increased EP4 phosphorylation, but did not induce sequestration or a reduction in [3H]PGE2 specific binding sites.	Tetradecanoylphorbol Acetate	62-93	prostaglandin E receptor 4	Homo sapiens	159-162
26343458-0	2015	Role of a TPA-responsive element in hepcidin transcription induced by the bone morphogenetic protein pathway.	Tetradecanoylphorbol Acetate	10-13	bone morphogenetic protein 1	Homo sapiens	74-100
26343458-3	2015	In addition to these elements, we previously identified a TPA-responsive element (TRE) in the hepcidin promoter and showed that it mediated the transcriptional activation of hepcidin through activator protein (AP)-1 induced by serum.	Tetradecanoylphorbol Acetate	58-61	hepcidin antimicrobial peptide	Homo sapiens	94-102
11477089-3	2001	The enhancement of human leukocyte antigen-DR alpha expression is at least due to the TPA-dependent induction of the IFN-gamma receptor 1 chain and IFN-gamma receptor 2 chain genes.	Tetradecanoylphorbol Acetate	86-89	interferon gamma receptor 1	Homo sapiens	117-137
11477089-4	2001	Here we have studied the mechanism of TPA-induced up-regulation of the IFN-gamma receptor 1 chain gene.	Tetradecanoylphorbol Acetate	38-41	interferon gamma receptor 1	Homo sapiens	71-91
26343458-3	2015	In addition to these elements, we previously identified a TPA-responsive element (TRE) in the hepcidin promoter and showed that it mediated the transcriptional activation of hepcidin through activator protein (AP)-1 induced by serum.	Tetradecanoylphorbol Acetate	58-61	hepcidin antimicrobial peptide	Homo sapiens	174-182
11477089-5	2001	Reporter gene analyses of 5"-deletion constructs of the IFN-gamma receptor 1 gene (IFNGR1) promoter indicated that the critical region for control of transcription and the TPA-responsive element (TRE) were present in the -128 to -109 base pair (bp) region.	Tetradecanoylphorbol Acetate	172-175	interferon gamma receptor 1	Homo sapiens	56-76
11477089-5	2001	Reporter gene analyses of 5"-deletion constructs of the IFN-gamma receptor 1 gene (IFNGR1) promoter indicated that the critical region for control of transcription and the TPA-responsive element (TRE) were present in the -128 to -109 base pair (bp) region.	Tetradecanoylphorbol Acetate	172-175	interferon gamma receptor 1	Homo sapiens	83-89
26269597-6	2015	Interestingly, silencing of PK (PKM2 and PKR) inhibited PMA-induced megakaryocytic differentiation, as revealed by decreased expression of megakaryocytic differentiation marker CD61 and cell cycle behavior.	Tetradecanoylphorbol Acetate	56-59	pyruvate kinase M1/2	Homo sapiens	32-36
11477089-6	2001	We confirmed that this region of the IFNGR1 promoter was responsive to TPA-induced signals by using a reporter construct whose promoter consisted of the -128 to -109 bp fragment and the minimal herpes simplex virus thymidine kinase promoter.	Tetradecanoylphorbol Acetate	71-74	interferon gamma receptor 1	Homo sapiens	37-43
11477089-8	2001	These results suggest that in TPA-treated cells the binding of Sp1 to the TRE of the IFNGR1 promoter causes the up-regulation of this gene.	Tetradecanoylphorbol Acetate	30-33	interferon gamma receptor 1	Homo sapiens	85-91
26268522-9	2015	CD4+CD25+ enriched PBL stimulated with PMA/Ionomycin in the presence of rIFNgamma were rather resistant to the effect of rIFNgamma, in contrast to CD4+CD25- enriched PBL which showed increasing total Treg with Helios+ Treg switching from IFNgamma- to IFNgamma+ and increasing Helios-IFNgamma+ Treg.	Tetradecanoylphorbol Acetate	39-42	interferon gamma	Rattus norvegicus	72-81
26222138-7	2015	In addition, PMA-inducible secretion of monocyte chemotactic protein 1 (MCP-1) was significantly high in NRF2-silenced U937.	Tetradecanoylphorbol Acetate	13-16	C-C motif chemokine ligand 2	Homo sapiens	40-70
11749770-6	2001	In parallel, 4-phorbol 12-myristate 13-acetate (PMA), an activator of PKC, also decreased the [Ca2+]i transient and increased the pHi.	Tetradecanoylphorbol Acetate	48-51	glucose-6-phosphate isomerase	Rattus norvegicus	130-133
26222138-7	2015	In addition, PMA-inducible secretion of monocyte chemotactic protein 1 (MCP-1) was significantly high in NRF2-silenced U937.	Tetradecanoylphorbol Acetate	13-16	C-C motif chemokine ligand 2	Homo sapiens	72-77
26175774-7	2015	Additionally, we examined whether lupenone, lupeol or taraxerol affects MUC5AC mucin production induced by epidermal growth factor (EGF) and phorbol 12-myristate 13-acetate (PMA), the other 2 stimulators of airway mucin production.	Tetradecanoylphorbol Acetate	141-172	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	72-78
11598794-3	2001	Indeed starved cells undergo apoptosis in the presence of constitutively elevated c-myc expression and the phorbol ester, phorbol 12-miristate 13-acetate (PMA), which rescues cells from apoptosis, induces complete c-myc down-regulation.	Tetradecanoylphorbol Acetate	155-158	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	214-219
26175774-9	2015	The 3 compounds inhibited the EGF or PMA-induced production of MUC5AC mucin in NCI-H292 cells.	Tetradecanoylphorbol Acetate	37-40	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	63-69
11668484-5	2001	Our results show that combined treatment with IFN-gamma and RA or the phorbol ester 12-O-tetradecanoyl-phorbol acetate (TPA) had synergistic or enhancing effects on morphologic differentiation and neurite outgrowth in 5 of 5 neuroblastoma cell lines, 3 of which expressed very high levels of N-myc mRNA due to N-myc amplification.	Tetradecanoylphorbol Acetate	84-118	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	292-297
11668484-5	2001	Our results show that combined treatment with IFN-gamma and RA or the phorbol ester 12-O-tetradecanoyl-phorbol acetate (TPA) had synergistic or enhancing effects on morphologic differentiation and neurite outgrowth in 5 of 5 neuroblastoma cell lines, 3 of which expressed very high levels of N-myc mRNA due to N-myc amplification.	Tetradecanoylphorbol Acetate	84-118	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	310-315
26116564-8	2015	Treatment of HT29 and Caco-2 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced an invasive phenotype response along with corresponding increases in ROS production and NOX2 and MMP-7 expression as well as reduced AMPK phosphorylation, which resemble basal conditions of highly invasive human colon cancer cells (SW620 and HCT116).	Tetradecanoylphorbol Acetate	40-76	matrix metallopeptidase 7	Homo sapiens	188-193
26116564-8	2015	Treatment of HT29 and Caco-2 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced an invasive phenotype response along with corresponding increases in ROS production and NOX2 and MMP-7 expression as well as reduced AMPK phosphorylation, which resemble basal conditions of highly invasive human colon cancer cells (SW620 and HCT116).	Tetradecanoylphorbol Acetate	78-81	matrix metallopeptidase 7	Homo sapiens	188-193
26116564-12	2015	TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 7	Homo sapiens	25-30
11578612-4	2001	We found that activation of PKA was ineffective, whereas treatment with the PKC agonist phorbol 12-myristate 13-acetate (PMA) caused a significant decrease in EAAC1 transport activity (IC(50)=44.7+/-12 nM).	Tetradecanoylphorbol Acetate	88-119	solute carrier family 1 member 1	Canis lupus familiaris	159-164
11578612-4	2001	We found that activation of PKA was ineffective, whereas treatment with the PKC agonist phorbol 12-myristate 13-acetate (PMA) caused a significant decrease in EAAC1 transport activity (IC(50)=44.7+/-12 nM).	Tetradecanoylphorbol Acetate	121-124	solute carrier family 1 member 1	Canis lupus familiaris	159-164
11578612-5	2001	PMA-induced EAAC1 inhibition was PKC-mediated because the inhibition could be blocked by specific PKC inhibitors and incubation with the inactive 4alpha-phorbol-12,13-didecanoate (4alpha-PDD) did not affect EAAC1.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 1 member 1	Canis lupus familiaris	12-17
11996904-10	2002	The phorbol ester, PMA (1 micromol/L), which activates the PKC pathway, and ionomycin (1 micromol/L), which activates the calcium pathway, produced small but detectable elevations in RGS-2 mRNA levels.	Tetradecanoylphorbol Acetate	19-22	regulator of G-protein signaling 2	Mus musculus	183-188
25847449-4	2015	These effects were more prominent following treatment with TPA in combination with DDTC than following treatment with either agent alone in PANC-1 cells in monolayer cultures and in 3 dimensional (3D) cultures.	Tetradecanoylphorbol Acetate	59-62	pancreas protein 1	Mus musculus	140-146
11996904-11	2002	Overnight treatment with 1 micromol/L PMA to deplete PKC did not affect subsequent RGS-2 induction by PTH, but significantly inhibited PMA-induced RGS-2 expression.	Tetradecanoylphorbol Acetate	38-41	regulator of G-protein signaling 2	Mus musculus	147-152
11996904-11	2002	Overnight treatment with 1 micromol/L PMA to deplete PKC did not affect subsequent RGS-2 induction by PTH, but significantly inhibited PMA-induced RGS-2 expression.	Tetradecanoylphorbol Acetate	135-138	regulator of G-protein signaling 2	Mus musculus	147-152
12222798-1	2002	Changes in urokinase-plasminogen activator (u-PA) and u-PA receptor (u-PAR) expression at the protein and mRNA level in resting neutrophils and in neutrophils activated by phorbol myristate acetate (PMA) were examined.	Tetradecanoylphorbol Acetate	172-197	plasminogen activator, urokinase	Bos taurus	44-48
11578612-5	2001	PMA-induced EAAC1 inhibition was PKC-mediated because the inhibition could be blocked by specific PKC inhibitors and incubation with the inactive 4alpha-phorbol-12,13-didecanoate (4alpha-PDD) did not affect EAAC1.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 1 member 1	Canis lupus familiaris	207-212
25847449-6	2015	Furthermore, treatment of nude mice with DDTC + TPA strongly inhibited the growth of PANC-1 xenograft tumors.	Tetradecanoylphorbol Acetate	48-51	pancreas protein 1	Mus musculus	85-91
11982754-11	2002	Agonists that induce keratinocyte differentiation, specifically 12-0-tetradecanoyl-phorbol-13-acetate (TPA) plus ionomycin, TPA, and raised extracellular calcium, induced nuclear translocation of NFAT1 and calcineurin in keratinocytes that was inhibited by pretreatment with cyclosporin A or tacrolimus.	Tetradecanoylphorbol Acetate	103-106	nuclear factor of activated T cells 2	Homo sapiens	196-201
25809288-6	2015	7,4"-Dihydroxyflavone significantly decreased phorbol 12-myristate 13-acetate-stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production, at a 28-fold lower concentration than glycyrrhizin (The half maximal inhibitory concentration IC50 value of 1.4 muM vs 38 muM, respectively); 7,4"-DHF also inhibited MUC5AC mucus secretion.	Tetradecanoylphorbol Acetate	46-77	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	127-133
11982754-11	2002	Agonists that induce keratinocyte differentiation, specifically 12-0-tetradecanoyl-phorbol-13-acetate (TPA) plus ionomycin, TPA, and raised extracellular calcium, induced nuclear translocation of NFAT1 and calcineurin in keratinocytes that was inhibited by pretreatment with cyclosporin A or tacrolimus.	Tetradecanoylphorbol Acetate	124-127	nuclear factor of activated T cells 2	Homo sapiens	196-201
12054651-6	2002	Addition of GTP[S] with PMA caused up to 40-50% of pleckstrin to be retained within platelets and enhanced secretion of platelet 5-hydroxytryptamine.	Tetradecanoylphorbol Acetate	24-27	pleckstrin	Homo sapiens	51-61
11554712-7	2001	In addition, we detected an almost identical increase of NHE-1 activity with the two methods after stimulation of protein kinase C using phorbol myristate acetate.	Tetradecanoylphorbol Acetate	137-162	solute carrier family 9 member A1	Canis lupus familiaris	57-62
25809288-6	2015	7,4"-Dihydroxyflavone significantly decreased phorbol 12-myristate 13-acetate-stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production, at a 28-fold lower concentration than glycyrrhizin (The half maximal inhibitory concentration IC50 value of 1.4 muM vs 38 muM, respectively); 7,4"-DHF also inhibited MUC5AC mucus secretion.	Tetradecanoylphorbol Acetate	46-77	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	338-344
11502881-3	2001	In this study, we investigated the effect of Wog on phorbol ester (PMA)-induced MCP-1 expression in human umbilical vein endothelial cells (ECs).	Tetradecanoylphorbol Acetate	67-70	C-C motif chemokine ligand 2	Homo sapiens	80-85
11502881-8	2001	Furthermore, the PMA-induced extracellular signal-regulated kinase 1/2 and c-Jun amino-terminal kinase activities that contributed to AP-1 activity and MCP-1 gene induction were obviously attenuated after pretreating ECs with Wog.	Tetradecanoylphorbol Acetate	17-20	C-C motif chemokine ligand 2	Homo sapiens	152-157
11821392-5	2002	Treatment with pervanadate or phorbol myristate acetate inhibits PLD more in HEK 293 cells overexpressing alpha-synuclein than in control cells.	Tetradecanoylphorbol Acetate	30-55	synuclein alpha	Homo sapiens	106-121
26062428-7	2015	RESULTS: Compared with healthy controls, CHB patients presented with significantly decreased peripheral blood NK/NKT cell ratio and significantly elevated proportions of NKG2A+ NK and NKG2A+NKT cells, and after the treatment with PMA/BFA/ionomycin, IFN-gamma+ NK and IFN-gamma+ NKT cells were significantly reduced in CHB patients.	Tetradecanoylphorbol Acetate	230-233	killer cell lectin like receptor C1	Homo sapiens	170-175
11893416-7	2002	NRE-A binding activity was also reduced when cells were treated with phorbol 12-myristate 13-acetate (PMA) plus ionomycin (ION).	Tetradecanoylphorbol Acetate	69-100	patatin-like phospholipase domain containing 7	Mus musculus	0-3
11375402-7	2001	In contrast, insertion of both the EGF domain and the MPR confers susceptibility to both slow constitutive shedding and the rapid proteolytic cleavage induced by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	162-193	epidermal growth factor	Mus musculus	35-38
11893416-7	2002	NRE-A binding activity was also reduced when cells were treated with phorbol 12-myristate 13-acetate (PMA) plus ionomycin (ION).	Tetradecanoylphorbol Acetate	102-105	patatin-like phospholipase domain containing 7	Mus musculus	0-3
26062428-7	2015	RESULTS: Compared with healthy controls, CHB patients presented with significantly decreased peripheral blood NK/NKT cell ratio and significantly elevated proportions of NKG2A+ NK and NKG2A+NKT cells, and after the treatment with PMA/BFA/ionomycin, IFN-gamma+ NK and IFN-gamma+ NKT cells were significantly reduced in CHB patients.	Tetradecanoylphorbol Acetate	230-233	killer cell lectin like receptor C1	Homo sapiens	184-189
11893416-8	2002	Cotreatment of VT potentiated PMA+ION-mediated reduction of the NRE-A binding activity in concentration-dependent fashion.	Tetradecanoylphorbol Acetate	30-34	patatin-like phospholipase domain containing 7	Mus musculus	64-67
25915860-0	2015	12-O-Tetradecanoylphorbol-13-Acetate Induces Up-Regulated Transcription of Variant 1 but Not Variant 2 of VIL2 in Esophageal Squamous Cell Carcinoma Cells via ERK1/2/AP-1/Sp1 Signaling.	Tetradecanoylphorbol Acetate	0-36	ezrin	Homo sapiens	106-110
12058964-6	2002	The Ets-1 protein was only detected in MDA-MB-231 cells and its level increased following TPA stimulation.	Tetradecanoylphorbol Acetate	90-93	ETS proto-oncogene 1, transcription factor	Homo sapiens	4-9
11504768-11	2001	In combination with TPA, carnosic acid potentiated the expression of VDR and RAR-alpha.	Tetradecanoylphorbol Acetate	20-23	retinoic acid receptor alpha	Homo sapiens	77-86
11443060-4	2001	Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) caused significant increases in APLP2 shedding.	Tetradecanoylphorbol Acetate	40-71	protein kinase C epsilon	Homo sapiens	32-35
11443060-4	2001	Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) caused significant increases in APLP2 shedding.	Tetradecanoylphorbol Acetate	73-76	protein kinase C epsilon	Homo sapiens	32-35
11443064-4	2001	By subcellular fractionation and Western blot, PMA (100 nM) induced sequential membrane translocation of the novel PKC epsilon followed by the conventional PKC alpha and activated both isozymes by in vitro kinase assay.	Tetradecanoylphorbol Acetate	47-50	protein kinase C epsilon	Homo sapiens	115-126
11960350-4	2002	Induction of monocytic differentiation in HL-60 cells by treatment with phorbol 12-myristate 13-acetate (PMA) led to rapid and sustained activation of MEK-1/-2, ERK-1/MAPK and ERK-2/MAPK, while induction of granulocytic differentiation by retinoic acid (RA) caused similar activation of MEK-1/-2 and ERK-2/MAPK, but not ERK-1/MAPK.	Tetradecanoylphorbol Acetate	72-103	mitogen-activated protein kinase kinase 1	Homo sapiens	151-159
11960350-4	2002	Induction of monocytic differentiation in HL-60 cells by treatment with phorbol 12-myristate 13-acetate (PMA) led to rapid and sustained activation of MEK-1/-2, ERK-1/MAPK and ERK-2/MAPK, while induction of granulocytic differentiation by retinoic acid (RA) caused similar activation of MEK-1/-2 and ERK-2/MAPK, but not ERK-1/MAPK.	Tetradecanoylphorbol Acetate	72-103	mitogen-activated protein kinase kinase 1	Homo sapiens	287-295
11960350-4	2002	Induction of monocytic differentiation in HL-60 cells by treatment with phorbol 12-myristate 13-acetate (PMA) led to rapid and sustained activation of MEK-1/-2, ERK-1/MAPK and ERK-2/MAPK, while induction of granulocytic differentiation by retinoic acid (RA) caused similar activation of MEK-1/-2 and ERK-2/MAPK, but not ERK-1/MAPK.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase kinase 1	Homo sapiens	151-159
25915860-5	2015	Here, we found that 12-O-tetradecanoylphorbol-13-acetate (TPA) induced over-expression of human VIL2 in esophageal squamous cell carcinoma (ESCC) cells.	Tetradecanoylphorbol Acetate	20-56	ezrin	Homo sapiens	96-100
11960350-4	2002	Induction of monocytic differentiation in HL-60 cells by treatment with phorbol 12-myristate 13-acetate (PMA) led to rapid and sustained activation of MEK-1/-2, ERK-1/MAPK and ERK-2/MAPK, while induction of granulocytic differentiation by retinoic acid (RA) caused similar activation of MEK-1/-2 and ERK-2/MAPK, but not ERK-1/MAPK.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase kinase 1	Homo sapiens	287-295
25915860-5	2015	Here, we found that 12-O-tetradecanoylphorbol-13-acetate (TPA) induced over-expression of human VIL2 in esophageal squamous cell carcinoma (ESCC) cells.	Tetradecanoylphorbol Acetate	58-61	ezrin	Homo sapiens	96-100
25915860-6	2015	Furthermore, VIL2 V1 but not V2 was up-regulated after TPA stimulation in a time-dependent manner.	Tetradecanoylphorbol Acetate	55-58	ezrin	Homo sapiens	13-17
11443064-7	2001	Inhibition of I(sc) by PMA was prevented by the conventional and novel PKC inhibitor Go-6850 (5 microM) but not the conventional isoform inhibitor Go-6976 (5 microM) or the PKC delta inhibitor rottlerin (10 microM), implicating PKC epsilon in inhibition of Cl(-) secretion.	Tetradecanoylphorbol Acetate	23-26	protein kinase C epsilon	Homo sapiens	228-239
25915860-7	2015	AP-1 and Sp1 binding sites within the promoter region of VIL2 V1 acted not only as basal transcriptional elements but also as a composite TPA-responsive element (TRE) for the transcription of VIL2 V1.	Tetradecanoylphorbol Acetate	138-141	ezrin	Homo sapiens	57-61
11923482-5	2002	Furthermore, we show that stimulation of 3T3-L1 adipocytes with phorbol-12-myristate-13-acetate or 8-(4-chlorophenyl)thio-cAMP induces the expression of Foxc2.	Tetradecanoylphorbol Acetate	64-95	forkhead box C2	Mus musculus	153-158
25915860-7	2015	AP-1 and Sp1 binding sites within the promoter region of VIL2 V1 acted not only as basal transcriptional elements but also as a composite TPA-responsive element (TRE) for the transcription of VIL2 V1.	Tetradecanoylphorbol Acetate	138-141	ezrin	Homo sapiens	192-196
11923482-8	2002	EMSA of nuclear proteins from phorbol-12-myristate-13-acetate- and TNF alpha-treated 3T3-L1 adipocytes using a forkhead consensus oligonucleotide revealed specific binding of a Foxc2/DNA complex.	Tetradecanoylphorbol Acetate	30-61	forkhead box C2	Mus musculus	177-182
11483407-13	2001	TNF-alpha- or TPA-induced ICAM-1 promoter activity was inhibited by dominant negative PKCalpha or IKK2, but not IKK1 mutant.	Tetradecanoylphorbol Acetate	14-17	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	98-102
11560779-0	2001	TPA-activated transcription of the human MnSOD gene: role of transcription factors Sp-1 and Egr-1.	Tetradecanoylphorbol Acetate	0-3	early growth response 1	Homo sapiens	92-97
25915860-8	2015	TPA stimulation enhanced c-Jun and Sp1 binding to the TRE via activation of the ERK1/2 pathway and increased protein levels of c-Jun, c-Fos, and Sp1, resulting in over-expression of VIL2 V1, whereas the MEK1/2 inhibitor U0126 blocked these events.	Tetradecanoylphorbol Acetate	0-3	ezrin	Homo sapiens	182-186
11560779-7	2001	The contributions of these binding sites and the roles of the transcription factors Egr-1, AP-2, and Sp1 in the activation of hMnSOD transcription by TPA were investigated by site-directed mutation analysis, Western blotting, and overexpression of transcription factors.	Tetradecanoylphorbol Acetate	150-153	early growth response 1	Homo sapiens	84-89
11948401-9	2002	The transcriptional activities of full-length JunB and full-length Fra-1, but not the transactivation domain fusions, were increased by TPA treatment and suppressed by RA.	Tetradecanoylphorbol Acetate	136-139	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	67-72
25915860-8	2015	TPA stimulation enhanced c-Jun and Sp1 binding to the TRE via activation of the ERK1/2 pathway and increased protein levels of c-Jun, c-Fos, and Sp1, resulting in over-expression of VIL2 V1, whereas the MEK1/2 inhibitor U0126 blocked these events.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 1	Homo sapiens	203-209
25915860-10	2015	Taken together, these results suggest that TPA is able to induce VIL2 V1 over-expression in ESCC cells by activating MEK/ERK1/2 signaling and increasing binding of Sp1 and c-Jun to the TRE of the VIL2 V1 promoter, and that VIL2 is an important TPA-induced effector.	Tetradecanoylphorbol Acetate	43-46	ezrin	Homo sapiens	65-69
11448162-4	2001	In such cells the PKC inhibitors 1-(5-isoquinolinesulphonyl)-2,5-dimethylpiperazine (H7) and staurosporine inhibited TPA-induced expression of BZLF1 and BRLF1 and reversed TPA-mediated inhibition of iNOS gene expression.	Tetradecanoylphorbol Acetate	117-120	protein Zta	Human gammaherpesvirus 4	143-148
11448162-5	2001	The mitogen-activated protein kinase inhibitor PD98059 inhibited TPA-induced BZLF1 expression.	Tetradecanoylphorbol Acetate	65-68	protein Zta	Human gammaherpesvirus 4	77-82
25915860-10	2015	Taken together, these results suggest that TPA is able to induce VIL2 V1 over-expression in ESCC cells by activating MEK/ERK1/2 signaling and increasing binding of Sp1 and c-Jun to the TRE of the VIL2 V1 promoter, and that VIL2 is an important TPA-induced effector.	Tetradecanoylphorbol Acetate	43-46	ezrin	Homo sapiens	196-200
11448162-8	2001	TPA-induced BZLF1 expression was also inhibited by the treatment with PDTC.	Tetradecanoylphorbol Acetate	0-3	protein Zta	Human gammaherpesvirus 4	12-17
25915860-10	2015	Taken together, these results suggest that TPA is able to induce VIL2 V1 over-expression in ESCC cells by activating MEK/ERK1/2 signaling and increasing binding of Sp1 and c-Jun to the TRE of the VIL2 V1 promoter, and that VIL2 is an important TPA-induced effector.	Tetradecanoylphorbol Acetate	43-46	ezrin	Homo sapiens	196-200
11744693-3	2002	Since the expression of PLD2 significantly enhanced phorbol 12-myristate 13-acetate (PMA)- or bradykinin-induced PLD activity in rat pheochromocytoma PC12 cells, we investigated the regulatory mechanism of PLD2 in PC12 cells.	Tetradecanoylphorbol Acetate	52-83	phospholipase D2	Rattus norvegicus	24-28
25915860-10	2015	Taken together, these results suggest that TPA is able to induce VIL2 V1 over-expression in ESCC cells by activating MEK/ERK1/2 signaling and increasing binding of Sp1 and c-Jun to the TRE of the VIL2 V1 promoter, and that VIL2 is an important TPA-induced effector.	Tetradecanoylphorbol Acetate	244-247	ezrin	Homo sapiens	196-200
11744693-3	2002	Since the expression of PLD2 significantly enhanced phorbol 12-myristate 13-acetate (PMA)- or bradykinin-induced PLD activity in rat pheochromocytoma PC12 cells, we investigated the regulatory mechanism of PLD2 in PC12 cells.	Tetradecanoylphorbol Acetate	85-88	phospholipase D2	Rattus norvegicus	24-28
11744693-9	2002	PKC delta co-immunoprecipitated with PLD2 from PC12 cell extracts, and associated with PLD2 in vitro in a PMA-dependent manner.	Tetradecanoylphorbol Acetate	106-109	phospholipase D2	Rattus norvegicus	87-91
11724286-5	2001	We found that both sulindac sulfide and TPA caused growth inhibition, cell cycle arrest in G0/G1 and increased levels of the cell cycle inhibitory proteins p21Cip1 and p27KiP1.	Tetradecanoylphorbol Acetate	40-43	cyclin dependent kinase inhibitor 1B	Homo sapiens	168-175
25908095-6	2015	Conversely, MAPK/p38 inactivation or REGgamma deletion prevents the increase of cyclinD1 and c-Myc by TPA.	Tetradecanoylphorbol Acetate	102-105	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	93-98
11877485-5	2002	In contrast, CD4(+) CD1d-restricted NKT cells potently produced both Th1 and Th2 cytokines, up-regulated perforin in response to stimulation by phorbol myristate acetate and ionomycin but not IL-2 or IL-12, and could be induced to express CD95L.	Tetradecanoylphorbol Acetate	144-169	CD1d molecule	Homo sapiens	20-24
11877485-5	2002	In contrast, CD4(+) CD1d-restricted NKT cells potently produced both Th1 and Th2 cytokines, up-regulated perforin in response to stimulation by phorbol myristate acetate and ionomycin but not IL-2 or IL-12, and could be induced to express CD95L.	Tetradecanoylphorbol Acetate	144-169	Fas ligand	Homo sapiens	239-244
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	0-31	insulin-like growth factor binding protein 5	Rattus norvegicus	227-234
25668518-5	2015	PMA, a pharmacologic NADPH oxidase activator, induced ER stress in dHL60 cells as monitored by IRE-1 and PERK pathway activation, and this was independent of calcium signaling.	Tetradecanoylphorbol Acetate	0-3	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	105-109
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	0-31	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	295-311
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	0-31	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	313-316
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	0-31	insulin-like growth factor binding protein 5	Rattus norvegicus	340-347
11495009-4	2001	Superoxide generation of neutrophils induced by phorbol myristate acetate (PMA) was delayed but intensified both by NRC and empty liposomes.	Tetradecanoylphorbol Acetate	48-73	nuclear receptor coactivator 6	Homo sapiens	116-119
11495009-4	2001	Superoxide generation of neutrophils induced by phorbol myristate acetate (PMA) was delayed but intensified both by NRC and empty liposomes.	Tetradecanoylphorbol Acetate	75-78	nuclear receptor coactivator 6	Homo sapiens	116-119
25460026-7	2015	AM404 also inhibited NF-kappaB activation induced by PMA/Ionomycin in SK-N-SH cells by targeting IKKbeta phosphorylation and activation.	Tetradecanoylphorbol Acetate	53-56	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	97-104
11458449-6	2001	In addition, baicalein inhibited the expressions of ELAM-1 and ICAM-1 stimulated by protein kinase C (PKC) activator phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	117-142	selectin E	Homo sapiens	52-58
11458449-6	2001	In addition, baicalein inhibited the expressions of ELAM-1 and ICAM-1 stimulated by protein kinase C (PKC) activator phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	144-147	selectin E	Homo sapiens	52-58
11327693-2	2001	We found that PMA-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) increased its binding with Tob that exerts an anti-proliferative effect through the binding with ErbB-2.	Tetradecanoylphorbol Acetate	14-17	transducer of ERBB2, 1	Homo sapiens	127-130
12041920-10	2002	Activators of intracellular signals such as 1 mM 8-bromo-cAMP and 1 microM phorbol myristate acetate had a similar effect to that obtained with GHRH.	Tetradecanoylphorbol Acetate	75-100	growth hormone releasing hormone	Gallus gallus	144-148
11751871-3	2002	Further analysis demonstrated that serum or 12-O-tetradecanoylphorbol-13-acetate activation of several immediate early genes including fos, fosB, junB, and egr1 was inhibited by Wnt signaling.	Tetradecanoylphorbol Acetate	44-80	early growth response 1	Homo sapiens	156-160
11380624-6	2001	Finally, in cells deficient in the PLC-gamma2, one of the phosphorylated substrates regulated by Syk and Btk, TPA-induced PLD activation, as well as phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis was remarkably reduced.	Tetradecanoylphorbol Acetate	110-113	spleen associated tyrosine kinase	Gallus gallus	97-100
25789788-6	2015	Importantly, Suv39h1 overexpression in mice confers resistance to a DMBA/TPA induced skin carcinogenesis protocol that is characterized by the accumulation of activating H-ras mutations.	Tetradecanoylphorbol Acetate	73-76	suppressor of variegation 3-9 1	Mus musculus	13-20
11380624-7	2001	CONCLUSIONS: We demonstrated that the Syk, Btk and PLC-gamma2 pathways are required for TPA-induced PLD activation in DT40 cells.	Tetradecanoylphorbol Acetate	88-91	spleen associated tyrosine kinase	Gallus gallus	38-41
11267995-2	2001	PC3 was originally isolated as a gene induced by nerve growth factor during neuronal differentiation of rat PC12 cells, or by TPA in NIH3T3 cells (named TIS21), and is a marker for neuronal birth in vivo.	Tetradecanoylphorbol Acetate	126-129	BTG anti-proliferation factor 2	Rattus norvegicus	0-3
11856352-7	2002	All-trans-RA blocked translocation of NFATp from the cytosol into the nucleus, which was induced by PMA/ionomycin treatment in HeLa cells transfected with a Flag-tagged NFATp.	Tetradecanoylphorbol Acetate	100-103	nuclear factor of activated T cells 2	Homo sapiens	38-43
11856352-7	2002	All-trans-RA blocked translocation of NFATp from the cytosol into the nucleus, which was induced by PMA/ionomycin treatment in HeLa cells transfected with a Flag-tagged NFATp.	Tetradecanoylphorbol Acetate	100-103	nuclear factor of activated T cells 2	Homo sapiens	169-174
25446551-5	2015	THP-1 cells express a low-affinity conformation of the integrin and adhered to OPN only in the presence of Mn(2+) plus PMA or an activating antibody.	Tetradecanoylphorbol Acetate	119-122	secreted phosphoprotein 1	Homo sapiens	79-82
11841540-6	2002	Treatment of melanoma cells with 12-O-tetradecanoylphorbol-13-acetate downregulated zyxin expression, inhibited cell spreading and proliferation, and promoted differentiation.	Tetradecanoylphorbol Acetate	33-69	zyxin	Homo sapiens	84-89
11841540-7	2002	In contrast, 12-O-tetradecanoylphorbol-13-acetate, a mitogen for melanocytes, induced upregulation of zyxin expression in melanocytes.	Tetradecanoylphorbol Acetate	13-49	zyxin	Homo sapiens	102-107
11809870-3	2002	We demonstrate here that steady-state IL-2 mRNA expression was significantly enhanced by CBN in a concentration-dependent manner in EL4 cells activated with suboptimal concentrations of phorbol-12-myristate-13-acetate (2-10 nM).	Tetradecanoylphorbol Acetate	186-217	interleukin 2	Mus musculus	38-42
11795879-4	2002	Finally, NADH/NADPH inhibitors prevent the p66(Shc) Ser-phosphorylation induced by serum and by phorbol 12-myristate-13-acetate, which suggests that the direct target(s) of reactive oxygen species is(are) located upstream from the machinery connecting growth factor receptors to Ras.	Tetradecanoylphorbol Acetate	96-127	DNA polymerase delta 3, accessory subunit	Homo sapiens	43-46
11506188-3	2001	PMA induced the activation of the ERK pathway as assessed by determining the phosphorylation state of ERK and the upstream component MEK1/2.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 1	Homo sapiens	133-139
11288140-4	2001	EGF, TPA and KCl induce NID67 only weakly.	Tetradecanoylphorbol Acetate	5-8	small integral membrane protein 3	Rattus norvegicus	24-29
11278336-5	2001	PMA-mediated induction of COX-2 promoter activity was inhibited by PPARgamma ligands; this suppressive effect was prevented by overexpressing a dominant negative form of PPARgamma or a PPAR response element decoy oligonucleotide.	Tetradecanoylphorbol Acetate	0-3	peroxisome proliferator activated receptor alpha	Homo sapiens	67-71
25520561-4	2014	We found that all cavin-1, -2 and -3 transcripts were expressed and that treatment with phorbol 12-myristate 13-acetate (PMA), which is known to prime cell migration and proliferation, specifically upregulated cavin-3 gene and protein expression.	Tetradecanoylphorbol Acetate	88-119	caveolae associated protein 3	Homo sapiens	210-217
12136940-4	2002	In this report we provide evidence that the GATA-1 factor regulates alphaV expression during differentiation of pluripotent K562 cells induced either by phorbol 12-myristate 13-acetate (PMA) or butyric acid (BA) through interaction with the GATA element in the alphaV gene promoter.	Tetradecanoylphorbol Acetate	153-184	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	44-48
12136940-4	2002	In this report we provide evidence that the GATA-1 factor regulates alphaV expression during differentiation of pluripotent K562 cells induced either by phorbol 12-myristate 13-acetate (PMA) or butyric acid (BA) through interaction with the GATA element in the alphaV gene promoter.	Tetradecanoylphorbol Acetate	186-189	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	44-48
25520561-4	2014	We found that all cavin-1, -2 and -3 transcripts were expressed and that treatment with phorbol 12-myristate 13-acetate (PMA), which is known to prime cell migration and proliferation, specifically upregulated cavin-3 gene and protein expression.	Tetradecanoylphorbol Acetate	121-124	caveolae associated protein 3	Homo sapiens	210-217
25520561-8	2014	Furthermore, recombinant cavin-3 significantly prevented PMA-mediated dephosphorylation of AKT, a crucial regulator in MMP-9 transcription.	Tetradecanoylphorbol Acetate	57-60	caveolae associated protein 3	Homo sapiens	25-32
12180265-5	2002	However, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) significantly accelerated the formation of fibrillar Fn.	Tetradecanoylphorbol Acetate	9-46	fibronectin 1	Bos taurus	106-108
25078038-4	2014	Our goal was to demonstrate the existence of B2R-beta2AR heterodimerisation in myocardium and to define its functional effect on cardiac release of tPA in vivo.	Tetradecanoylphorbol Acetate	148-151	B2 bradykinin receptor	Sus scrofa	45-48
12180265-5	2002	However, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) significantly accelerated the formation of fibrillar Fn.	Tetradecanoylphorbol Acetate	48-51	fibronectin 1	Bos taurus	106-108
12180265-6	2002	The clustering of integrin and vinculin was enhanced and inhibited by TPA and forskolin, respectively.	Tetradecanoylphorbol Acetate	70-73	vinculin	Bos taurus	31-39
11743653-3	2002	Judging from the expression of various inflammatory cytokine genes in TNF+/+ and TNF-/- mice, the residual tumor promoting activity of TPA in TNF-/- mice may be dependent on expression of IL-1alpha and IL-1beta genes.	Tetradecanoylphorbol Acetate	135-138	interleukin 1 alpha	Mus musculus	188-197
11287779-6	2001	The stimulating effect of high glucose on MCP-1 expression in HMC was mimicked by activation of protein kinase C (PKC) with the phorbol ester PMA (20 nM).	Tetradecanoylphorbol Acetate	142-145	C-C motif chemokine ligand 2	Homo sapiens	42-47
11124936-5	2001	In 32D cells, Rap1 was also activated by phorbol 12-myristate 13-acetate and ionomycin, which also enhanced cell adhesion to fibronectin, whereas, an inhibitor of phospholipase C, inhibited both cytokine-induced activation of Rap1 and cell adhesion.	Tetradecanoylphorbol Acetate	41-72	fibronectin 1	Mus musculus	125-136
25022544-7	2014	To determine the role of PKC activation in the effects of DPP-4 inhibitors, cells were treated with PMA- which blocked the effect of DPP-4 inhibitors on NLRP3 and IL-1beta as well as TLR4 and GLP-1R.	Tetradecanoylphorbol Acetate	100-103	dipeptidyl peptidase 4	Homo sapiens	58-63
11851881-9	2002	12-O-tetradecanoylphorbol-13-acetate treatment resulted in an increase in tumor necrosis factor and interleukin-1alpha staining in the epidermis that was reduced by clofibrate treatment.	Tetradecanoylphorbol Acetate	0-36	interleukin 1 alpha	Mus musculus	100-118
12090568-5	2002	GM-CSF receptor (GM-CSFR) was down-regulated by GM-CSF or phorbol 12-myristate 13-acetate in both of the normal controls and SLE patients, while this change was more remarkable in the latter.	Tetradecanoylphorbol Acetate	58-89	colony stimulating factor 2	Homo sapiens	0-6
25022544-7	2014	To determine the role of PKC activation in the effects of DPP-4 inhibitors, cells were treated with PMA- which blocked the effect of DPP-4 inhibitors on NLRP3 and IL-1beta as well as TLR4 and GLP-1R.	Tetradecanoylphorbol Acetate	100-103	dipeptidyl peptidase 4	Homo sapiens	133-138
11756554-8	2002	Fra-1 was activated by TPA in ERK-sufficient P(+) cells but not in ERK-deficient P(-) cells.	Tetradecanoylphorbol Acetate	23-26	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	0-5
25038529-3	2014	In this study, we show that senescent human umbilical vein endothelial cells lose their ability to induce tissue factor (TF), a transmembrane protein with important roles in hemostasis and cancer progression, in response to thrombin or - independently of cell-surface receptors - phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	280-311	coagulation factor III, tissue factor	Homo sapiens	106-119
11934475-7	2002	In contrast, the strong inhibitory effect on dendritic growth by the PKC activator phorbol-12-myristate-13-acetate (PMA) did not require the presence of the PKCgamma isoform since it was still present in the cultures of PKCgamma-deficient mice.	Tetradecanoylphorbol Acetate	116-119	protein kinase C, gamma	Mus musculus	69-72
12220559-5	2002	Activation of PKC with intracaudate injection of 12-O-tetradecanoylphorbol-13-acetate (TPA) mimicked DHPG actions in facilitating the phosphorylation of CREB, Elk-1, and ERK1/2.	Tetradecanoylphorbol Acetate	49-85	cAMP responsive element binding protein 1	Rattus norvegicus	153-157
12220559-5	2002	Activation of PKC with intracaudate injection of 12-O-tetradecanoylphorbol-13-acetate (TPA) mimicked DHPG actions in facilitating the phosphorylation of CREB, Elk-1, and ERK1/2.	Tetradecanoylphorbol Acetate	87-90	cAMP responsive element binding protein 1	Rattus norvegicus	153-157
12220559-6	2002	Blockade of N-methyl-D-aspartate (NMDA) glutamate receptors with the non-competitive antagonist MK801 or the competitive antagonist AP5 attenuated TPA-induced CREB, Elk-1, and ERK1/2 phosphorylation.	Tetradecanoylphorbol Acetate	147-150	cAMP responsive element binding protein 1	Rattus norvegicus	159-163
25038529-3	2014	In this study, we show that senescent human umbilical vein endothelial cells lose their ability to induce tissue factor (TF), a transmembrane protein with important roles in hemostasis and cancer progression, in response to thrombin or - independently of cell-surface receptors - phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	280-311	coagulation factor III, tissue factor	Homo sapiens	121-123
11841692-8	2002	The CTLA-4 expression was upregulated upon treatment with phorbol 12-myristate 13-acetate (PMA) and IFN-gamma.	Tetradecanoylphorbol Acetate	58-89	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	4-10
11841692-8	2002	The CTLA-4 expression was upregulated upon treatment with phorbol 12-myristate 13-acetate (PMA) and IFN-gamma.	Tetradecanoylphorbol Acetate	91-94	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	4-10
24996056-2	2014	Here, we confirmed that IL-32theta, a new isoform of IL-32, decreased the phorbol 12-myristate 13-acetate (PMA)-induced IL-1beta expression in THP-1 human myelomonocyte.	Tetradecanoylphorbol Acetate	74-105	interleukin 32	Homo sapiens	24-29
11701232-4	2001	Phorbol-12-myristate-13-acetate increased PPARalpha mRNA levels without altering ACOX mRNA levels.	Tetradecanoylphorbol Acetate	0-31	peroxisome proliferator activated receptor alpha	Rattus norvegicus	42-51
24996056-2	2014	Here, we confirmed that IL-32theta, a new isoform of IL-32, decreased the phorbol 12-myristate 13-acetate (PMA)-induced IL-1beta expression in THP-1 human myelomonocyte.	Tetradecanoylphorbol Acetate	107-110	interleukin 32	Homo sapiens	24-29
11740186-5	2001	MATERIALS AND METHODS: A new technique was developed to detect cytokine expression in phorbol 12-myristate 13-acetate/ionomycin-activated CD62L and alpha4beta7-expressing CD4 T cell subsets, using the protease inhibitor KD-IX-73-4.	Tetradecanoylphorbol Acetate	86-117	selectin L	Homo sapiens	138-143
24037529-5	2014	In contrast, TPA-promoted (that is, c-fos-activated) bi-genic HK1.ras-Delta5PTEN(flx) cohorts lost p53/p21 expression during early papillomatogenesis and rapidly produced poorly differentiated carcinomas (pdSCCs) with high BrdU-labelling and elevated cyclin D1/E2 expression levels, indicative of a progression mechanism driven by failures in cell-cycle control.	Tetradecanoylphorbol Acetate	13-16	FBJ osteosarcoma oncogene	Mus musculus	36-41
11696370-2	2001	We observed (i) NAD-dependent enzyme activity and mRNA for 11beta-HSD2, but not 11beta-HSD1, (ii) increasing 11beta-HSD2 activity with increasing degree of differentiation and (iii) a concentration-dependent down-regulation by TNF-alpha, phorbol myristate acetate (PMA) or glucose of activity and mRNA of 11beta-HSD2.	Tetradecanoylphorbol Acetate	265-268	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	59-70
24037529-5	2014	In contrast, TPA-promoted (that is, c-fos-activated) bi-genic HK1.ras-Delta5PTEN(flx) cohorts lost p53/p21 expression during early papillomatogenesis and rapidly produced poorly differentiated carcinomas (pdSCCs) with high BrdU-labelling and elevated cyclin D1/E2 expression levels, indicative of a progression mechanism driven by failures in cell-cycle control.	Tetradecanoylphorbol Acetate	13-16	transformation related protein 53, pseudogene	Mus musculus	99-102
11696370-2	2001	We observed (i) NAD-dependent enzyme activity and mRNA for 11beta-HSD2, but not 11beta-HSD1, (ii) increasing 11beta-HSD2 activity with increasing degree of differentiation and (iii) a concentration-dependent down-regulation by TNF-alpha, phorbol myristate acetate (PMA) or glucose of activity and mRNA of 11beta-HSD2.	Tetradecanoylphorbol Acetate	265-268	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	109-120
24720768-10	2014	RESULTS: LMX1b-R198X enhanced the IL-6 promoter activity activated by the wild-type LMX1b and diminished the promoter activity induced by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	138-169	LIM homeobox transcription factor 1 beta	Homo sapiens	9-14
11696370-2	2001	We observed (i) NAD-dependent enzyme activity and mRNA for 11beta-HSD2, but not 11beta-HSD1, (ii) increasing 11beta-HSD2 activity with increasing degree of differentiation and (iii) a concentration-dependent down-regulation by TNF-alpha, phorbol myristate acetate (PMA) or glucose of activity and mRNA of 11beta-HSD2.	Tetradecanoylphorbol Acetate	265-268	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	109-120
11675357-3	2001	Furthermore, the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate, which stimulates sphingosine kinase, the enzyme responsible for S-1P production, also inhibits cytochrome c and Smac/DIABLO release.	Tetradecanoylphorbol Acetate	32-69	diablo IAP-binding mitochondrial protein	Homo sapiens	183-187
24508175-6	2014	Although stimulation of cytokine production by PMA and ionomycin reduced ZSWIM1 expression, the relative differences in abundance between the cell types were maintained.	Tetradecanoylphorbol Acetate	47-50	zinc finger SWIM-type containing 1	Homo sapiens	73-79
11675357-3	2001	Furthermore, the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate, which stimulates sphingosine kinase, the enzyme responsible for S-1P production, also inhibits cytochrome c and Smac/DIABLO release.	Tetradecanoylphorbol Acetate	32-69	diablo IAP-binding mitochondrial protein	Homo sapiens	188-194
11710937-6	2001	This study also involves the first investigation of the effects of aging on c-myc expression by 12-O-tetradecanoyl-phorbol-13-acetate treatment.	Tetradecanoylphorbol Acetate	96-133	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	76-81
24552404-6	2014	RESULTS: The PMA-induced respiratory burst was significantly inhibited (p &lt; 0.05) by six isoprenylated phenolics (AS1-6) at the concentration of 20 microM (below the toxic concentration) with the inhibition rate ranging from 25.0 to 99.6%.	Tetradecanoylphorbol Acetate	13-16	PDS5 cohesin associated factor B	Rattus norvegicus	117-122
11922601-4	2001	Op18 phosphorylation is rapidly induced with phorbol myristate acetate (PMA) treatment in a wide range of human cells.	Tetradecanoylphorbol Acetate	45-70	stathmin 1	Homo sapiens	0-4
11922601-4	2001	Op18 phosphorylation is rapidly induced with phorbol myristate acetate (PMA) treatment in a wide range of human cells.	Tetradecanoylphorbol Acetate	72-75	stathmin 1	Homo sapiens	0-4
24831767-7	2014	RESULTS: Monocytes derived from peripheral blood mononuclear cells cultured in interleukin-4 and granulocyte macrophage colony stimulating factor differentiated into immature dendritic cells that phenotypically differentiated into mature dendritic cells in response to conditioned media from phorbol myristate acetate-activated THP-1 monocytes.	Tetradecanoylphorbol Acetate	292-317	colony stimulating factor 2	Homo sapiens	97-145
11591175-4	2001	pRb is dephosphorylated in the presence of p21-CDK2/4 complexes, and the Rb-E2F1 complex increases after TPA treatment, whereas the Rb-HDAC1 complex decreases slightly.	Tetradecanoylphorbol Acetate	105-108	E2F transcription factor 1	Homo sapiens	76-80
25019390-10	2014	Treatment with the PKC agonist phorbol 12-myristate 13-acetate (PMA) increased phosphorylation of PKC substrates and MAPK and increased p34cdc2 kinase activity.	Tetradecanoylphorbol Acetate	31-62	cyclin dependent kinase 1	Homo sapiens	136-143
11564702-7	2001	Phorbol 12-myristate-13-acetate and N-ethylmaleimide increased the accumulation of leptin binding protein, an indication that the production of leptin binding protein was up-regulated by PKC and sulfhydryl group activation.	Tetradecanoylphorbol Acetate	0-31	leptin	Homo sapiens	83-89
11564702-7	2001	Phorbol 12-myristate-13-acetate and N-ethylmaleimide increased the accumulation of leptin binding protein, an indication that the production of leptin binding protein was up-regulated by PKC and sulfhydryl group activation.	Tetradecanoylphorbol Acetate	0-31	leptin	Homo sapiens	144-150
25019390-10	2014	Treatment with the PKC agonist phorbol 12-myristate 13-acetate (PMA) increased phosphorylation of PKC substrates and MAPK and increased p34cdc2 kinase activity.	Tetradecanoylphorbol Acetate	64-67	cyclin dependent kinase 1	Homo sapiens	136-143
24654232-8	2014	Stimulation of control SSM with phorbol 12-myristate 13-acetate (PMA), a PKC activator, increased both calcium tolerance and mitochondrial Cx43 phosphorylation at S262 and S368.	Tetradecanoylphorbol Acetate	32-63	protein kinase C epsilon	Homo sapiens	73-76
11746821-2	2001	Although ODC was one of the first genes described whose product is inducible by 12-O-tetradecanoylphorbol-13-acetate (TPA), the mechanisms of ODC transcriptional regulation have remained elusive.	Tetradecanoylphorbol Acetate	80-116	ornithine decarboxylase 1	Rattus norvegicus	9-12
11746821-2	2001	Although ODC was one of the first genes described whose product is inducible by 12-O-tetradecanoylphorbol-13-acetate (TPA), the mechanisms of ODC transcriptional regulation have remained elusive.	Tetradecanoylphorbol Acetate	118-121	ornithine decarboxylase 1	Rattus norvegicus	9-12
11746821-3	2001	In this study, we systematically analyzed the rat ODC core promoter region for novel TPA response elements.	Tetradecanoylphorbol Acetate	85-88	ornithine decarboxylase 1	Rattus norvegicus	50-53
11746821-4	2001	Analysis of linker scanning mutants of the ODC promoter from the TATA box to the transcription start site demonstrated that mutation of the TATA box reduced the TPA induction ratio by 40%, while the basal ODC promoter activity was not significantly changed.	Tetradecanoylphorbol Acetate	161-164	ornithine decarboxylase 1	Rattus norvegicus	43-46
24654232-8	2014	Stimulation of control SSM with phorbol 12-myristate 13-acetate (PMA), a PKC activator, increased both calcium tolerance and mitochondrial Cx43 phosphorylation at S262 and S368.	Tetradecanoylphorbol Acetate	65-68	protein kinase C epsilon	Homo sapiens	73-76
12030804-4	2001	Pretreatment with phorbol 12-myristate 13-acetate (PMA) completely abolished these effects for both NE and NPY.	Tetradecanoylphorbol Acetate	18-49	neuropeptide Y	Homo sapiens	107-110
24952939-3	2014	Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to 7, 12-dimethylbenz(a)anthracene (DMBA)-/12-O-tetra decanoylphorbol-13 acetate (TPA)-induced skin carcinogenesis.	Tetradecanoylphorbol Acetate	170-173	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	53-56
12030804-4	2001	Pretreatment with phorbol 12-myristate 13-acetate (PMA) completely abolished these effects for both NE and NPY.	Tetradecanoylphorbol Acetate	51-54	neuropeptide Y	Homo sapiens	107-110
24952939-3	2014	Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to 7, 12-dimethylbenz(a)anthracene (DMBA)-/12-O-tetra decanoylphorbol-13 acetate (TPA)-induced skin carcinogenesis.	Tetradecanoylphorbol Acetate	170-173	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	57-61
11489969-7	2001	Stimulatory activity of TPA on HCMV replication was suppressed by protein kinase C inhibitors and inhibitors of p42/44 and p38 mitogen-activated protein kinases but not by NF-kappaB inhibitors.	Tetradecanoylphorbol Acetate	24-27	cyclin dependent kinase 20	Homo sapiens	112-115
24952939-5	2014	In addition, lack of p65 strongly inhibited TPA-induced epidermal hyperplasia and skin inflammation by suppressing the expression of proinflammatory cytokines and chemokines by epidermal keratinocytes.	Tetradecanoylphorbol Acetate	44-47	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	21-24
11509337-7	2001	We found that after a 24-h incubation with GM-CSF, AP-1 DNA binding was significantly increased in both unstimulated, interleukin (IL)-13, and phorbol myristate acetate (PMA)-stimulated alveolar macrophages and that there was a corresponding increase in Ref-1 protein by Western blot analysis in the PMA-stimulated group.	Tetradecanoylphorbol Acetate	143-168	colony stimulating factor 2	Homo sapiens	43-49
24952939-6	2014	Therefore, p65-dependent NF-kappaB signalling in keratinocytes promotes DMBA-/TPA-induced skin carcinogenesis by protecting keratinocytes from DNA damage-induced death and facilitating the establishment of a tumour-nurturing proinflammatory microenvironment.	Tetradecanoylphorbol Acetate	78-81	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	11-14
11509337-7	2001	We found that after a 24-h incubation with GM-CSF, AP-1 DNA binding was significantly increased in both unstimulated, interleukin (IL)-13, and phorbol myristate acetate (PMA)-stimulated alveolar macrophages and that there was a corresponding increase in Ref-1 protein by Western blot analysis in the PMA-stimulated group.	Tetradecanoylphorbol Acetate	170-173	colony stimulating factor 2	Homo sapiens	43-49
11509337-7	2001	We found that after a 24-h incubation with GM-CSF, AP-1 DNA binding was significantly increased in both unstimulated, interleukin (IL)-13, and phorbol myristate acetate (PMA)-stimulated alveolar macrophages and that there was a corresponding increase in Ref-1 protein by Western blot analysis in the PMA-stimulated group.	Tetradecanoylphorbol Acetate	300-303	colony stimulating factor 2	Homo sapiens	43-49
24464434-0	2014	Roles of PKC Isoforms in PMA-Induced Modulation of the hERG Channel (Kv11.1).	Tetradecanoylphorbol Acetate	25-28	potassium voltage-gated channel subfamily H member 2	Homo sapiens	69-75
11488907-9	2001	This finding suggests that TPA-inducible MDR1 transcription mediated through the TPA responsive factor early growth response 1 (EGR-1) in this region of the promoter may be due to activation of PKC-alpha.	Tetradecanoylphorbol Acetate	27-30	early growth response 1	Homo sapiens	128-133
11488907-9	2001	This finding suggests that TPA-inducible MDR1 transcription mediated through the TPA responsive factor early growth response 1 (EGR-1) in this region of the promoter may be due to activation of PKC-alpha.	Tetradecanoylphorbol Acetate	81-84	early growth response 1	Homo sapiens	128-133
11466413-3	2001	The formation of PICK1-PKCalpha complexes is strongly induced by TPA, and PICK1-PKCalpha complexes are cotargeted with PICK1-GluR2 complexes to spines, where GluR2 is found to be phosphorylated by PKC on serine 880.	Tetradecanoylphorbol Acetate	65-68	protein interacting with PRKCA 1	Homo sapiens	17-22
23564320-11	2014	We have found that, H3-Thr45 phosphorylation correlates to S6K activation in response to mitogens and TPA-induced cell differentiation of leukaemic cell lines U937, HL60 and THP1.	Tetradecanoylphorbol Acetate	102-105	ribosomal protein S6 kinase B1	Homo sapiens	59-62
11587480-0	2001	Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	181-217	phosphoglycolate phosphatase	Homo sapiens	65-69
11435342-5	2001	VSMCs from p47phox(+/+) but not those from p47phox(-/-) mice produced superoxide after stimulation by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	102-127	neutrophil cytosolic factor 1	Mus musculus	11-18
24732112-5	2014	Furthermore, the effect of the extracts, EUG and IMT, was studied on phorbol-12-myristate-13-acetate (PMA) induced monocyte to macrophage differentiation and gene expression of CD14, TLR2 and TLR4.	Tetradecanoylphorbol Acetate	69-100	toll like receptor 4	Homo sapiens	192-196
11421596-7	2001	When the neurons were exposed to Phorbol 12-myristate 13-acetate (PMA), alpha1-antichymotrypsin, or alpha1-antitrypsin, the alterations of soluble Abeta levels were consistent with other models reported.	Tetradecanoylphorbol Acetate	33-64	amyloid beta (A4) precursor protein	Mus musculus	147-152
11421596-7	2001	When the neurons were exposed to Phorbol 12-myristate 13-acetate (PMA), alpha1-antichymotrypsin, or alpha1-antitrypsin, the alterations of soluble Abeta levels were consistent with other models reported.	Tetradecanoylphorbol Acetate	66-69	amyloid beta (A4) precursor protein	Mus musculus	147-152
24732112-5	2014	Furthermore, the effect of the extracts, EUG and IMT, was studied on phorbol-12-myristate-13-acetate (PMA) induced monocyte to macrophage differentiation and gene expression of CD14, TLR2 and TLR4.	Tetradecanoylphorbol Acetate	102-105	toll like receptor 4	Homo sapiens	192-196
24732112-10	2014	In addition, they showed significant inhibition on PMA induced monocyte to macrophage differentiation and the gene expression of CD14, TLR2 and TLR4 markers.	Tetradecanoylphorbol Acetate	51-54	toll like receptor 4	Homo sapiens	144-148
24744737-3	2014	We investigated whether SCA14 mutations affect the gammaPKC-related functions by stimulating HeLa cells with TPA (12-O-tetradecanoylpholbol 13-acetate), a type of phorbol ester.	Tetradecanoylphorbol Acetate	109-112	protein kinase C gamma	Homo sapiens	24-29
11384667-5	2001	Using the auto-fluorescence of K-562 cells, flow cytometry can be used to demonstrate a significant decrease in CD56+ LGL activity against K-562 cells in populations pre-incubated with PMA.	Tetradecanoylphorbol Acetate	185-188	neural cell adhesion molecule 1	Homo sapiens	112-116
24744737-4	2014	Wild-type (WT) gammaPKC-GFP was translocated to the plasma membrane within 10 min of TPA stimulation, followed by its perinuclear translocation and cell shrinkage, in a PKC kinase activity- and microtubule-dependent manner.	Tetradecanoylphorbol Acetate	85-88	protein kinase C gamma	Homo sapiens	20-23
11461971-6	2001	TPA-dependent ERK phosphorylation was also blocked by the MEK1 inhibitors PD098059 or U0126.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 1	Homo sapiens	58-62
24744737-5	2014	On the other hand, although SCA14 mutant gammaPKC-GFP exhibited a similar translocation to the plasma membrane, the subsequent perinuclear translocation and cell shrinkage were significantly impaired in response to TPA.	Tetradecanoylphorbol Acetate	215-218	protein kinase C gamma	Homo sapiens	28-33
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	54-85	lysine demethylase and nuclear receptor corepressor	Mus musculus	179-181
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	54-85	lysine demethylase and nuclear receptor corepressor	Mus musculus	269-271
24744737-8	2014	Moreover, TPA induced the phosphorylation of MARCKS, which is a membrane-substrate of PKC, resulting in the translocation of phosphorylated MARCKS to the perinuclear region, suggesting that TPA induces macropinocytosis via gammaPKC activation.	Tetradecanoylphorbol Acetate	10-13	protein kinase C gamma	Homo sapiens	86-89
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	87-90	lysine demethylase and nuclear receptor corepressor	Mus musculus	179-181
24744737-8	2014	Moreover, TPA induced the phosphorylation of MARCKS, which is a membrane-substrate of PKC, resulting in the translocation of phosphorylated MARCKS to the perinuclear region, suggesting that TPA induces macropinocytosis via gammaPKC activation.	Tetradecanoylphorbol Acetate	190-193	protein kinase C gamma	Homo sapiens	86-89
24134140-6	2014	This conformational change was associated with faster phorbol 12-myristate 13-acetate-induced translocation and accumulation of fully phosphorylated PKCgamma in the insoluble fraction, which could be rescued by coexpressing PDK1 kinase that normally triggers PKCgamma autophosphorylation.	Tetradecanoylphorbol Acetate	54-85	protein kinase C gamma	Homo sapiens	149-157
11356667-7	2001	We next determined the decay rate of the ERbeta mRNA in granulosa cells that were cultured in the presence of DRB and additional hCG, FSK, or TPA for various time periods, by estimating ERbeta mRNA levels, using semiquantitative RT-PCR assays and subsequent linear regression analyses.	Tetradecanoylphorbol Acetate	142-145	estrogen receptor 2	Rattus norvegicus	41-47
11356667-10	2001	Similarly, both FSK and TPA decreased the half-life of the ERbeta mRNA to 3.57 +/- 0.31 h and 4.02 +/- 0.13 h, respectively.	Tetradecanoylphorbol Acetate	24-27	estrogen receptor 2	Rattus norvegicus	59-65
11356667-12	2001	When granulosa cells were cultured in the presence of cycloheximide, a protein synthesis inhibitor, the inhibitory effects of hCG, FSK, and TPA on ERbeta mRNA levels were abolished.	Tetradecanoylphorbol Acetate	140-143	estrogen receptor 2	Rattus norvegicus	147-153
24134140-6	2014	This conformational change was associated with faster phorbol 12-myristate 13-acetate-induced translocation and accumulation of fully phosphorylated PKCgamma in the insoluble fraction, which could be rescued by coexpressing PDK1 kinase that normally triggers PKCgamma autophosphorylation.	Tetradecanoylphorbol Acetate	54-85	protein kinase C gamma	Homo sapiens	259-267
24134140-9	2014	This leads to unusually fast phorbol 12-myristate 13-acetate-induced membrane translocation and accumulation of phosphorylated PKCgamma-V138E in the insoluble fraction, causing loss of the functional kinase.	Tetradecanoylphorbol Acetate	29-60	protein kinase C gamma	Homo sapiens	127-135
11400151-3	2001	Phorbol-12-myristate-13-acetate, interleukin-6, and tumour necrosis factor-alpha and heparin with the tumour promoter or cytokines potently enhanced (up to nine-fold) MMP-8 and -13 expression by the RPMI 8226 myeloma cell line, as evidenced by western blotting and semi-quantitative reverse transcriptase-polymerase chain reaction.	Tetradecanoylphorbol Acetate	0-31	matrix metallopeptidase 8	Homo sapiens	167-180
24246020-7	2014	After being co-cultured with Phorbol 12-myristate 13-acetate, ionomycin and monensin, the expression level of interferon (IFN)-gamma in the dNK cells was detected by FCM.	Tetradecanoylphorbol Acetate	29-60	deoxyribonucleoside kinase	Drosophila melanogaster	140-143
11465087-4	2001	Moreover, stimulation with phorbol 12-myristate 13-acetate increased endocytosis of IgM-coated microparticles mediated by the Fc alpha/mu receptor expressed on pro-B cell line Ba/F3 cells.	Tetradecanoylphorbol Acetate	27-58	Fc receptor, IgA, IgM, high affinity	Mus musculus	126-146
24258363-3	2014	Pretreatment with MSE in mouse skin has led to the reduction of TPA-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunits as well as phosphorylation of IkappaBalpha and p65 subsequent reduction of IkappaBalpha degradation.	Tetradecanoylphorbol Acetate	64-67	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	194-197
24465855-0	2014	PEP-1-PON1 protein regulates inflammatory response in raw 264.7 macrophages and ameliorates inflammation in a TPA-induced animal model.	Tetradecanoylphorbol Acetate	110-113	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	0-5
11313461-6	2001	In contrast, PMA treatment or long-term TRH stimulation resulted in the presence of F-actin and beta-catenin at the cell-cell contacts and their exclusion from the rest of the plasma membrane.	Tetradecanoylphorbol Acetate	13-16	catenin beta 1	Homo sapiens	96-108
11313920-3	2001	FGF-BP is upregulated in squamous cell carcinoma by treatment with mitogens such as EGF or TPA.	Tetradecanoylphorbol Acetate	91-94	fibroblast growth factor binding protein 1	Homo sapiens	0-6
24433534-4	2014	METHODS: In this study, the possible mechanisms underlying Gen-mediated reduction of 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced cell invasion and inhibition of secreted and cytosolic MMP-9 production in human hepatoma cells (HepG2, Huh-7, and HA22T) and murine embryonic liver cells (BNL CL2) were investigated.	Tetradecanoylphorbol Acetate	85-121	doublecortin-like kinase 2	Mus musculus	296-299
11115506-10	2001	Various CYP11B2 promoter constructs were used to identify the area associated with TPA and PKC inhibition.	Tetradecanoylphorbol Acetate	83-86	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	8-15
11278385-7	2001	Therefore, these results demonstrate that the sequential ERK/RSK1/NF-kappaB pathway mediates PMA-stimulated megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	93-96	ribosomal protein S6 kinase A1	Homo sapiens	61-65
11290607-12	2001	Furthermore, other inducers of differentiation, all-trans-retinoic acid and 12-O-tetradecanoylphorbol 13-acetate, increased PTEN expression in HL-60.	Tetradecanoylphorbol Acetate	76-112	phosphatase and tensin homolog	Homo sapiens	124-128
24433534-4	2014	METHODS: In this study, the possible mechanisms underlying Gen-mediated reduction of 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced cell invasion and inhibition of secreted and cytosolic MMP-9 production in human hepatoma cells (HepG2, Huh-7, and HA22T) and murine embryonic liver cells (BNL CL2) were investigated.	Tetradecanoylphorbol Acetate	123-126	doublecortin-like kinase 2	Mus musculus	296-299
25099774-2	2014	The aim of this work was to measure the expression of genes in the ovaries of GHRKO and normal (N) mice treated with phorbol 12-myristate 13-acetate (PMA), an inhibitor of GH and IRS1 signaling.	Tetradecanoylphorbol Acetate	117-148	insulin receptor substrate 1	Mus musculus	179-183
11277940-3	2001	Here, we show that prolonged exposure of cells to phorbol esters results in a decrease in guanylate cyclase C content in 4beta-phorbol 12-myristate 13-acetate-treated cells, as a consequence of a decrease in guanylate cyclase C mRNA levels.	Tetradecanoylphorbol Acetate	121-158	natriuretic peptide receptor 3	Homo sapiens	90-109
11277940-3	2001	Here, we show that prolonged exposure of cells to phorbol esters results in a decrease in guanylate cyclase C content in 4beta-phorbol 12-myristate 13-acetate-treated cells, as a consequence of a decrease in guanylate cyclase C mRNA levels.	Tetradecanoylphorbol Acetate	121-158	natriuretic peptide receptor 3	Homo sapiens	208-227
11405060-6	2001	uPAR in phorbol-12-myristate-13-acetate-stimulated chondrocytes colocalized with caveolin as well as beta 1-integrin, as demonstrated by double immunostaining with specific antibodies.	Tetradecanoylphorbol Acetate	8-39	plasminogen activator, urokinase receptor	Homo sapiens	0-4
11238119-7	2001	Moreover, the generation of NK1.1+ T cells with invariant Valpha14Jalpha281 chains was induced from the NK1.1+ CD3- thymocytes following stimulation with phorbol myristate acetate and ionomycin in a neonatal thymic organ culture.	Tetradecanoylphorbol Acetate	154-179	killer cell lectin-like receptor subfamily B member 1C	Mus musculus	28-33
11238119-7	2001	Moreover, the generation of NK1.1+ T cells with invariant Valpha14Jalpha281 chains was induced from the NK1.1+ CD3- thymocytes following stimulation with phorbol myristate acetate and ionomycin in a neonatal thymic organ culture.	Tetradecanoylphorbol Acetate	154-179	killer cell lectin-like receptor subfamily B member 1C	Mus musculus	104-109
11282557-2	2001	Enhancement in transcription of c-fos has been shown in the murine P388D1 macrophage line treated by LPS, TPA, Ca++ ionophore or dibutyryl cAMP.	Tetradecanoylphorbol Acetate	106-109	FBJ osteosarcoma oncogene	Mus musculus	32-37
25099774-2	2014	The aim of this work was to measure the expression of genes in the ovaries of GHRKO and normal (N) mice treated with phorbol 12-myristate 13-acetate (PMA), an inhibitor of GH and IRS1 signaling.	Tetradecanoylphorbol Acetate	150-153	insulin receptor substrate 1	Mus musculus	179-183
11310852-1	2001	Apolipoprotein C-II (apoC-II), which is known to activate lipoprotein lipase (LPL), was identified by ordered differential display (ODD)-polymerase chain reaction (PCR) as a cDNA fragment exhibiting a distinct increase in expression during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of promonocytic U937 cells into monocytes and macrophages.	Tetradecanoylphorbol Acetate	240-276	lipoprotein lipase	Homo sapiens	58-76
11310852-1	2001	Apolipoprotein C-II (apoC-II), which is known to activate lipoprotein lipase (LPL), was identified by ordered differential display (ODD)-polymerase chain reaction (PCR) as a cDNA fragment exhibiting a distinct increase in expression during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of promonocytic U937 cells into monocytes and macrophages.	Tetradecanoylphorbol Acetate	240-276	lipoprotein lipase	Homo sapiens	78-81
26229980-3	2014	Previous studies, using phorbol-myristate-acetate (PMA) as a differentiating agent, have suggested that the CD34+/CD38+ TF-1 cell line may be used as one model to study the differentiation processes of HPCs.	Tetradecanoylphorbol Acetate	24-49	CD38 molecule	Homo sapiens	114-118
11310852-1	2001	Apolipoprotein C-II (apoC-II), which is known to activate lipoprotein lipase (LPL), was identified by ordered differential display (ODD)-polymerase chain reaction (PCR) as a cDNA fragment exhibiting a distinct increase in expression during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of promonocytic U937 cells into monocytes and macrophages.	Tetradecanoylphorbol Acetate	278-281	lipoprotein lipase	Homo sapiens	58-76
11310852-1	2001	Apolipoprotein C-II (apoC-II), which is known to activate lipoprotein lipase (LPL), was identified by ordered differential display (ODD)-polymerase chain reaction (PCR) as a cDNA fragment exhibiting a distinct increase in expression during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of promonocytic U937 cells into monocytes and macrophages.	Tetradecanoylphorbol Acetate	278-281	lipoprotein lipase	Homo sapiens	78-81
11287749-2	2001	However, when cells are in suspension or in the presence of cytochalasin D which disrupts the intracellular network of actin microfilaments, TPA loses its ability to stimulate tyrosine phosphorylation of FAK and paxillin but it still activates mitogen-activated protein kinase (MAPK) and induces PKC translocation from cytosol to the membrane in HepG2 cells.	Tetradecanoylphorbol Acetate	141-144	paxillin	Homo sapiens	212-220
26229980-3	2014	Previous studies, using phorbol-myristate-acetate (PMA) as a differentiating agent, have suggested that the CD34+/CD38+ TF-1 cell line may be used as one model to study the differentiation processes of HPCs.	Tetradecanoylphorbol Acetate	51-54	CD38 molecule	Homo sapiens	114-118
11226521-4	2001	Promoter deletion analyses revealed that the activator protein-1 (AP-1) transcription factor site was crucial for 12-O-tetradecanoyl phorbol 13-acetate (TPA)-mediated GSTP1 gene transcription.	Tetradecanoylphorbol Acetate	114-151	glutathione S-transferase pi 1	Homo sapiens	167-172
11283231-11	2001	Application of the phorbol ester phorbol 12-myristate 13-acetate (PMA; 1 M) shifted the voltage dependence of erg1 activation in the depolarizing direction, but it did not reduce the maximal current amplitude.	Tetradecanoylphorbol Acetate	33-64	potassium voltage-gated channel subfamily H member 2	Rattus norvegicus	110-114
11283231-11	2001	Application of the phorbol ester phorbol 12-myristate 13-acetate (PMA; 1 M) shifted the voltage dependence of erg1 activation in the depolarizing direction, but it did not reduce the maximal current amplitude.	Tetradecanoylphorbol Acetate	66-69	potassium voltage-gated channel subfamily H member 2	Rattus norvegicus	110-114
11226521-4	2001	Promoter deletion analyses revealed that the activator protein-1 (AP-1) transcription factor site was crucial for 12-O-tetradecanoyl phorbol 13-acetate (TPA)-mediated GSTP1 gene transcription.	Tetradecanoylphorbol Acetate	153-156	glutathione S-transferase pi 1	Homo sapiens	167-172
24211779-6	2013	Treatment of HUVECs with H2O2 or phorbol myristate acetate (PMA) led to tyrosine phosphorylation of VE-cadherin, dissociation of beta-catenin from VE-cadherin complex and increased transendothelial migration (TEM) of MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	33-58	catenin beta 1	Homo sapiens	129-141
11226521-7	2001	These results show for the first time that the phorbol ester TPA is involved in the molecular mechanism(s) mediating the activation of the GSTP1 promoter in a human leukemia model.	Tetradecanoylphorbol Acetate	61-64	glutathione S-transferase pi 1	Homo sapiens	139-144
11267936-5	2001	Upon differentiation-induction with 12-O-tetradecanoylphorbol-13-acetate (TPA), in TTC549, showing an expression of TGF-alpha but not EGF initially, de novo expression of EGF mRNA appeared abruptly on day 2 of TPA treatment.	Tetradecanoylphorbol Acetate	36-72	epidermal growth factor	Homo sapiens	171-174
11267936-5	2001	Upon differentiation-induction with 12-O-tetradecanoylphorbol-13-acetate (TPA), in TTC549, showing an expression of TGF-alpha but not EGF initially, de novo expression of EGF mRNA appeared abruptly on day 2 of TPA treatment.	Tetradecanoylphorbol Acetate	74-77	epidermal growth factor	Homo sapiens	134-137
11267936-5	2001	Upon differentiation-induction with 12-O-tetradecanoylphorbol-13-acetate (TPA), in TTC549, showing an expression of TGF-alpha but not EGF initially, de novo expression of EGF mRNA appeared abruptly on day 2 of TPA treatment.	Tetradecanoylphorbol Acetate	74-77	epidermal growth factor	Homo sapiens	171-174
11267936-5	2001	Upon differentiation-induction with 12-O-tetradecanoylphorbol-13-acetate (TPA), in TTC549, showing an expression of TGF-alpha but not EGF initially, de novo expression of EGF mRNA appeared abruptly on day 2 of TPA treatment.	Tetradecanoylphorbol Acetate	210-213	epidermal growth factor	Homo sapiens	171-174
11259631-9	2001	Because C/EBP beta, a basic leucine zipper transcription factor, can be activated via a PKC alpha/mitogen-activated protein kinase pathway and can influence COX-2 expression, we examined whether C/EBP beta is involved in TPA-induced epidermal COX-2 expression.	Tetradecanoylphorbol Acetate	221-224	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	195-205
11259631-10	2001	TPA-induced COX-2 expression was similar in C/EBP beta nullizygous and wild-type mice.	Tetradecanoylphorbol Acetate	0-3	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	44-54
11113116-1	2001	Plasminogen activator inhibitor-1 (PAI-1) is a serpin protease inhibitor that binds plasminogen activators (uPA and tPA) at a reactive center loop located at the carboxyl-terminal amino acid residues 320-351.	Tetradecanoylphorbol Acetate	116-119	serpin family E member 1	Homo sapiens	0-33
11113116-1	2001	Plasminogen activator inhibitor-1 (PAI-1) is a serpin protease inhibitor that binds plasminogen activators (uPA and tPA) at a reactive center loop located at the carboxyl-terminal amino acid residues 320-351.	Tetradecanoylphorbol Acetate	116-119	serpin family E member 1	Homo sapiens	35-40
11113116-5	2001	The region we maintained corresponds to amino acids 80-265 of mature human PAI-1 containing binding sites for vitronectin, heparin (partial), uPA, tPA, fibrin, thrombin, and the helix F region.	Tetradecanoylphorbol Acetate	147-150	serpin family E member 1	Homo sapiens	75-80
24211779-6	2013	Treatment of HUVECs with H2O2 or phorbol myristate acetate (PMA) led to tyrosine phosphorylation of VE-cadherin, dissociation of beta-catenin from VE-cadherin complex and increased transendothelial migration (TEM) of MDA-MB-231 cells.	Tetradecanoylphorbol Acetate	60-63	catenin beta 1	Homo sapiens	129-141
11313866-4	2001	Treatment of TSU-Pr1 cells with TPA for 15 min or longer resulted in translocation of PKCalpha, PKCgamma, and PKCepsilon from cytosolic to membrane fraction.	Tetradecanoylphorbol Acetate	32-35	protein kinase C gamma	Homo sapiens	96-104
11313866-4	2001	Treatment of TSU-Pr1 cells with TPA for 15 min or longer resulted in translocation of PKCalpha, PKCgamma, and PKCepsilon from cytosolic to membrane fraction.	Tetradecanoylphorbol Acetate	32-35	protein kinase C epsilon	Homo sapiens	110-120
24368897-3	2013	Using rat primary astrocytes, confocal immunofluorescence and ultracentrifugation on sucrose gradient we here report that PKC activation by phorbol myristate acetate (PMA) reorganizes EAAT-1 distribution and reduces functional [(3)H]-aspartate reuptake.	Tetradecanoylphorbol Acetate	140-165	solute carrier family 1 member 3	Rattus norvegicus	184-190
11313866-5	2001	Our results suggest that TPA-induced TSU-Pr1 cell differentiation is associated with activation of MAP kinase and PKCalpha, PKCgamma, and PKCepsilon.	Tetradecanoylphorbol Acetate	25-28	protein kinase C gamma	Homo sapiens	124-132
11313866-5	2001	Our results suggest that TPA-induced TSU-Pr1 cell differentiation is associated with activation of MAP kinase and PKCalpha, PKCgamma, and PKCepsilon.	Tetradecanoylphorbol Acetate	25-28	protein kinase C epsilon	Homo sapiens	138-148
11238950-5	2001	We also found that the Rac1-GTP level decreased after stimulation with TPA and that the Rac1-IQGAP1 complexes decreased, while the IQGAP1-beta-catenin complexes increased during action of TPA.	Tetradecanoylphorbol Acetate	188-191	IQ motif containing GTPase activating protein 1	Canis lupus familiaris	93-99
11238950-5	2001	We also found that the Rac1-GTP level decreased after stimulation with TPA and that the Rac1-IQGAP1 complexes decreased, while the IQGAP1-beta-catenin complexes increased during action of TPA.	Tetradecanoylphorbol Acetate	188-191	IQ motif containing GTPase activating protein 1	Canis lupus familiaris	131-137
11160869-6	2001	Selective depletion of cellular PKC-betaII and -epsilon by exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA) or treatment of cells with PKC-betaII inhibitor G06976 reversed the effect of glimepiride on intracellular insulin-receptor processing.	Tetradecanoylphorbol Acetate	71-107	protein kinase C epsilon	Homo sapiens	32-55
11160869-6	2001	Selective depletion of cellular PKC-betaII and -epsilon by exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA) or treatment of cells with PKC-betaII inhibitor G06976 reversed the effect of glimepiride on intracellular insulin-receptor processing.	Tetradecanoylphorbol Acetate	109-112	protein kinase C epsilon	Homo sapiens	32-55
11231886-4	2001	Topical application of curcumin was reported to inhibit TPA-induced c-fos, c-jun and c-myc gene expression in mouse skin.	Tetradecanoylphorbol Acetate	56-59	FBJ osteosarcoma oncogene	Mus musculus	68-73
11238950-6	2001	Constitutively active Rac1 and IQGAP1 carboxyl terminus, a putative dominant-negative mutant of IQGAP1, inhibited the disappearance of alpha-catenin from sites of cell-cell contact induced by TPA.	Tetradecanoylphorbol Acetate	192-195	IQ motif containing GTPase activating protein 1	Canis lupus familiaris	31-37
11231886-8	2001	CONCLUSIONS: Whereas earlier work demonstrated that topical application of curcumin to mouse skin inhibited TPA-induced expression of c-fos, c-jun and c-myc oncogenes, our results are the first to show that orally consumed curcumin significantly inhibited DMBA- and TPA-induced ras and fos gene expression in mouse skin.	Tetradecanoylphorbol Acetate	108-111	FBJ osteosarcoma oncogene	Mus musculus	134-139
11238950-6	2001	Constitutively active Rac1 and IQGAP1 carboxyl terminus, a putative dominant-negative mutant of IQGAP1, inhibited the disappearance of alpha-catenin from sites of cell-cell contact induced by TPA.	Tetradecanoylphorbol Acetate	192-195	IQ motif containing GTPase activating protein 1	Canis lupus familiaris	96-102
24368897-3	2013	Using rat primary astrocytes, confocal immunofluorescence and ultracentrifugation on sucrose gradient we here report that PKC activation by phorbol myristate acetate (PMA) reorganizes EAAT-1 distribution and reduces functional [(3)H]-aspartate reuptake.	Tetradecanoylphorbol Acetate	167-170	solute carrier family 1 member 3	Rattus norvegicus	184-190
11231886-8	2001	CONCLUSIONS: Whereas earlier work demonstrated that topical application of curcumin to mouse skin inhibited TPA-induced expression of c-fos, c-jun and c-myc oncogenes, our results are the first to show that orally consumed curcumin significantly inhibited DMBA- and TPA-induced ras and fos gene expression in mouse skin.	Tetradecanoylphorbol Acetate	108-111	FBJ osteosarcoma oncogene	Mus musculus	136-139
24067898-10	2013	Immunohistochemistry confirmed higher MMP9 staining in 12-O-tetradecanoylphorbol-13-acetate-treated skin from Tpl2 (-/-) mice and grafted tumors formed from v-ras(Ha) retrovirus-infected Tpl2 (-/-) keratinocytes.	Tetradecanoylphorbol Acetate	55-91	mitogen-activated protein kinase kinase kinase 8	Mus musculus	110-114
11746511-8	2001	In contrast, phorbol-12-myristate-13-acetate (PMA), an activator of PKC, stimulated OPG promoter expression, while thapsigargin and calcium ionophore A23187, which increase intracellular Ca(2+), showed a dose-dependent inhibition of OPG promoter expression.	Tetradecanoylphorbol Acetate	13-44	TNF receptor superfamily member 11B	Rattus norvegicus	84-87
11746511-8	2001	In contrast, phorbol-12-myristate-13-acetate (PMA), an activator of PKC, stimulated OPG promoter expression, while thapsigargin and calcium ionophore A23187, which increase intracellular Ca(2+), showed a dose-dependent inhibition of OPG promoter expression.	Tetradecanoylphorbol Acetate	46-49	TNF receptor superfamily member 11B	Rattus norvegicus	84-87
11234878-5	2001	uPAR mRNA level was increased 11-fold over a 24-h period in low-grade glioma cell lines after treatment with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	109-134	plasminogen activator, urokinase receptor	Homo sapiens	0-4
11746511-8	2001	In contrast, phorbol-12-myristate-13-acetate (PMA), an activator of PKC, stimulated OPG promoter expression, while thapsigargin and calcium ionophore A23187, which increase intracellular Ca(2+), showed a dose-dependent inhibition of OPG promoter expression.	Tetradecanoylphorbol Acetate	46-49	TNF receptor superfamily member 11B	Rattus norvegicus	233-236
11160843-5	2001	The intracellular concentration of annexin V increased with the addition of PKC activator (12-O:-tetradecanoylphorbor-13-acetate; TPA) much as it did with the addition of buserelin, and the rise in the concentration caused by the addition of buserelin was completely attenuated by pretreatment with PKC inhibitor (calphostin C).	Tetradecanoylphorbol Acetate	130-133	annexin A5	Homo sapiens	35-44
24403255-2	2013	Because heretofore the role of IL-4 in DMBA/TPA (9,10-dimethyl-1,2-benz-anthracene/12-O-tetradecanoylphorbol-13-acetate) two-stage carcinogenesis was not studied, we performed such experiments using either IL-4(-/-) or IL-4Ralpha(-/-) mice.	Tetradecanoylphorbol Acetate	44-47	interleukin 4	Mus musculus	31-35
11050091-8	2001	PMA could also activate a signaling pathway involving MEK1/ERK2/c-Jun-dependent uPA expression.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 1	Homo sapiens	54-58
27891249-10	2013	Using a peptide inhibitor of PKC epsilon, PMA-induced reactive oxygen species (ROS) production could be reduced to that of a normal B-LCL.	Tetradecanoylphorbol Acetate	42-45	protein kinase C epsilon	Homo sapiens	29-40
11139333-5	2001	LTD(4)-induced Ca(2+) signaling was significantly suppressed in cells pretreated with TPA for 15 min and was abolished when the pretreatment was prolonged to 2 h. Immunoblot analysis revealed that the reduction in the LTD(4)-induced calcium signal coincided with a reduction in the cellular content of PKCepsilon and, to a limited extent, PKCdelta.	Tetradecanoylphorbol Acetate	86-89	protein kinase C epsilon	Homo sapiens	302-312
11042220-2	2001	Peripheral blood mononuclear cells treated with phorbol 12-myristate 13-acetate showed steady state levels of nucleolin mRNA that were 2-2.5-fold greater than untreated control cells.	Tetradecanoylphorbol Acetate	48-79	LOW QUALITY PROTEIN: nucleolin	Oryctolagus cuniculus	110-119
11220710-8	2001	Insulin and tPA-Ag contributed to PAI-1 (adj.	Tetradecanoylphorbol Acetate	12-15	serpin family E member 1	Homo sapiens	34-39
11042220-4	2001	Calcium ionophores and ionomycin also activated ERK and substantially elevated nucleolin mRNA levels, demonstrating phorbol 12-myristate 13-acetate and calcium signaling converge on ERK.	Tetradecanoylphorbol Acetate	116-147	LOW QUALITY PROTEIN: nucleolin	Oryctolagus cuniculus	79-88
24284098-4	2013	METHODS: Skin squamous cell carcinoma was induced in CD1 mice by dimethylbenzanthracene (DMBA) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) followed by a PDT protocol for four weeks.	Tetradecanoylphorbol Acetate	99-136	CD1 antigen complex	Mus musculus	53-56
11313949-8	2001	Furthermore, PMA treatment of the CT51 cells induced cell spreading and cellular relocalization of the CEACAM1-L protein.	Tetradecanoylphorbol Acetate	13-16	carcinoembryonic antigen-related cell adhesion molecule 1	Mus musculus	103-110
11172467-6	2001	In addition, the phorbol myristate acetate (PMA)-stimulated or PMA-nonstimulated 22-kd a-subunit (p22phox) mRNA levels and 47-kd a-subunit (p47phox) protein levels in NADPH oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	17-42	cytochrome b-245 alpha chain	Homo sapiens	98-105
11172467-6	2001	In addition, the phorbol myristate acetate (PMA)-stimulated or PMA-nonstimulated 22-kd a-subunit (p22phox) mRNA levels and 47-kd a-subunit (p47phox) protein levels in NADPH oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	17-42	peroxisome proliferator activated receptor alpha	Homo sapiens	214-223
11172467-6	2001	In addition, the phorbol myristate acetate (PMA)-stimulated or PMA-nonstimulated 22-kd a-subunit (p22phox) mRNA levels and 47-kd a-subunit (p47phox) protein levels in NADPH oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	44-47	cytochrome b-245 alpha chain	Homo sapiens	98-105
11172467-6	2001	In addition, the phorbol myristate acetate (PMA)-stimulated or PMA-nonstimulated 22-kd a-subunit (p22phox) mRNA levels and 47-kd a-subunit (p47phox) protein levels in NADPH oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	44-47	peroxisome proliferator activated receptor alpha	Homo sapiens	214-223
11172467-6	2001	In addition, the phorbol myristate acetate (PMA)-stimulated or PMA-nonstimulated 22-kd a-subunit (p22phox) mRNA levels and 47-kd a-subunit (p47phox) protein levels in NADPH oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	63-66	cytochrome b-245 alpha chain	Homo sapiens	98-105
11172467-6	2001	In addition, the phorbol myristate acetate (PMA)-stimulated or PMA-nonstimulated 22-kd a-subunit (p22phox) mRNA levels and 47-kd a-subunit (p47phox) protein levels in NADPH oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	63-66	peroxisome proliferator activated receptor alpha	Homo sapiens	214-223
24284098-4	2013	METHODS: Skin squamous cell carcinoma was induced in CD1 mice by dimethylbenzanthracene (DMBA) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) followed by a PDT protocol for four weeks.	Tetradecanoylphorbol Acetate	138-141	CD1 antigen complex	Mus musculus	53-56
23900415-8	2013	Inhibition of activin signaling during PKC stimulation through silencing of the inhibin betaA-subunit or blocking of the activin type I receptor opposed the PMA-induced downregulation of CYP17A1 expression and P450c17 function.	Tetradecanoylphorbol Acetate	157-160	inhibin subunit beta E	Homo sapiens	14-21
11010963-3	2001	Here, we report that the ligand binding activity of the VLDL-R in THP-1 monocytic cells, endothelial cells, smooth muscle cells, and VLDL-R-transfected HEK 293 cells is diminished after treatment with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	201-232	very low density lipoprotein receptor	Homo sapiens	56-62
11120776-6	2000	MBL binding to polymorphonuclear leukocytes (PMNs) was associated positively with changes in CR1 expression induced by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	119-144	mannose binding lectin 2	Homo sapiens	0-3
23900415-8	2013	Inhibition of activin signaling during PKC stimulation through silencing of the inhibin betaA-subunit or blocking of the activin type I receptor opposed the PMA-induced downregulation of CYP17A1 expression and P450c17 function.	Tetradecanoylphorbol Acetate	157-160	inhibin subunit beta E	Homo sapiens	121-128
11010963-3	2001	Here, we report that the ligand binding activity of the VLDL-R in THP-1 monocytic cells, endothelial cells, smooth muscle cells, and VLDL-R-transfected HEK 293 cells is diminished after treatment with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	201-232	very low density lipoprotein receptor	Homo sapiens	133-139
23517917-1	2013	Although tetradecanoyl phorbol acetate induced sequence-7 (TIS7) has been identified as a co-activator/repressor of gene transcription in different eukaryotic cells, little attention has been paid to the functionality of TIS7 in adipocytes.	Tetradecanoylphorbol Acetate	9-38	interferon-related developmental regulator 1	Mus musculus	59-63
12064598-4	2001	Selective inhibition of PKCE significantly decreased baseline levels of Cx43 phosphorylation and the PMA-induced accumulation of &gt; or = 45 kDa Cx43.	Tetradecanoylphorbol Acetate	101-104	protein kinase C epsilon	Homo sapiens	24-28
11746514-3	2001	Midazolam inhibited the accumulation of HSP27 induced by vasopressin or 12-O-tetradecanoylphorbol 13-acetate (TPA), a direct activator of protein kinase C. Midazolam also reduced the vasopressin-induced level of the mRNA for HSP27.	Tetradecanoylphorbol Acetate	72-108	heat shock protein family B (small) member 1	Homo sapiens	40-45
11746514-3	2001	Midazolam inhibited the accumulation of HSP27 induced by vasopressin or 12-O-tetradecanoylphorbol 13-acetate (TPA), a direct activator of protein kinase C. Midazolam also reduced the vasopressin-induced level of the mRNA for HSP27.	Tetradecanoylphorbol Acetate	110-113	heat shock protein family B (small) member 1	Homo sapiens	40-45
11746514-3	2001	Midazolam inhibited the accumulation of HSP27 induced by vasopressin or 12-O-tetradecanoylphorbol 13-acetate (TPA), a direct activator of protein kinase C. Midazolam also reduced the vasopressin-induced level of the mRNA for HSP27.	Tetradecanoylphorbol Acetate	110-113	heat shock protein family B (small) member 1	Homo sapiens	225-230
10993886-6	2000	Interestingly, low salicylate concentrations (&lt;/=250 microm) inhibit p70(s6k) activation by phorbol myristate acetate, while higher salicylate concentrations (&gt;/=5 mm) are required to block p70(s6k) activation by epidermal growth factor + insulin-like growth factor-1.	Tetradecanoylphorbol Acetate	95-120	ribosomal protein S6 kinase B1	Homo sapiens	72-79
11113530-7	2000	Dexamethasone (DEX; 1 microM) further enhanced FSK- or PMA-induced proENK mRNA expression, which was not correlated with the activation of AP-1 expression and CREB phosphorylation, suggesting that synergistic interaction of glucocorticoid with PKA or PKC pathway for the regulation of proENK mRNA expression appears to be mediated by other pathways rather than CREB and AP-1 families.	Tetradecanoylphorbol Acetate	55-58	proenkephalin	Rattus norvegicus	67-73
11113530-1	2000	In rat astrocytes, forskolin (FSK; 5 microM) and phorbol-12-myristic-13-acetate (PMA; 2.5 microM) increase the proenkephalin (proENK) mRNA level via different pathways.	Tetradecanoylphorbol Acetate	81-84	proenkephalin	Rattus norvegicus	111-124
11113530-1	2000	In rat astrocytes, forskolin (FSK; 5 microM) and phorbol-12-myristic-13-acetate (PMA; 2.5 microM) increase the proenkephalin (proENK) mRNA level via different pathways.	Tetradecanoylphorbol Acetate	81-84	proenkephalin	Rattus norvegicus	126-132
11113530-3	2000	This is in contrast to PMA-induced proENK mRNA expression that is dependent on protein de novo synthesis and is well correlated with the increase of AP-1 DNA binding activity rather than CREB phosphorylation.	Tetradecanoylphorbol Acetate	23-26	proenkephalin	Rattus norvegicus	35-41
23612789-5	2013	Although both drugs promote DAT internalization above constitutive endocytosis in dopamine neurons, PMA induces ubiquitination of DAT and leads to accumulation of DAT on LAMP1-positive endosomes.	Tetradecanoylphorbol Acetate	100-103	lysosomal-associated membrane protein 1	Rattus norvegicus	170-175
11113530-3	2000	This is in contrast to PMA-induced proENK mRNA expression that is dependent on protein de novo synthesis and is well correlated with the increase of AP-1 DNA binding activity rather than CREB phosphorylation.	Tetradecanoylphorbol Acetate	23-26	cAMP responsive element binding protein 1	Rattus norvegicus	187-191
11113530-6	2000	The combined treatment with FSK and PMA additively increased the proENK mRNA level, which was correlated with AP-1 or ENKCRE-2 DNA binding activity, and CREB phosphorylation.	Tetradecanoylphorbol Acetate	36-39	proenkephalin	Rattus norvegicus	65-71
11113530-6	2000	The combined treatment with FSK and PMA additively increased the proENK mRNA level, which was correlated with AP-1 or ENKCRE-2 DNA binding activity, and CREB phosphorylation.	Tetradecanoylphorbol Acetate	36-39	cAMP responsive element binding protein 1	Rattus norvegicus	153-157
23715767-7	2013	Suppression of Egr-1 expression by siRNA abrogated the ability of TPA to induce Egr-1 and JNK-1 activities, moderately increasing the p21 activity and abrogating the anti-apoptotic effect of Egr-1 observed in the prostate cancer cell lines.	Tetradecanoylphorbol Acetate	66-69	early growth response 1	Homo sapiens	15-20
23715767-7	2013	Suppression of Egr-1 expression by siRNA abrogated the ability of TPA to induce Egr-1 and JNK-1 activities, moderately increasing the p21 activity and abrogating the anti-apoptotic effect of Egr-1 observed in the prostate cancer cell lines.	Tetradecanoylphorbol Acetate	66-69	early growth response 1	Homo sapiens	80-85
11046057-5	2000	However, PD98059 weakly affected PMA-induced p47(phox) phosphorylation, even though ERK1/2 activation was abrogated.	Tetradecanoylphorbol Acetate	33-36	inhibitor of growth family member 1	Homo sapiens	45-48
11113530-7	2000	Dexamethasone (DEX; 1 microM) further enhanced FSK- or PMA-induced proENK mRNA expression, which was not correlated with the activation of AP-1 expression and CREB phosphorylation, suggesting that synergistic interaction of glucocorticoid with PKA or PKC pathway for the regulation of proENK mRNA expression appears to be mediated by other pathways rather than CREB and AP-1 families.	Tetradecanoylphorbol Acetate	55-58	proenkephalin	Rattus norvegicus	285-291
11113530-7	2000	Dexamethasone (DEX; 1 microM) further enhanced FSK- or PMA-induced proENK mRNA expression, which was not correlated with the activation of AP-1 expression and CREB phosphorylation, suggesting that synergistic interaction of glucocorticoid with PKA or PKC pathway for the regulation of proENK mRNA expression appears to be mediated by other pathways rather than CREB and AP-1 families.	Tetradecanoylphorbol Acetate	55-58	cAMP responsive element binding protein 1	Rattus norvegicus	361-365
11046057-5	2000	However, PD98059 weakly affected PMA-induced p47(phox) phosphorylation, even though ERK1/2 activation was abrogated.	Tetradecanoylphorbol Acetate	33-36	inhibitor of growth family member 1	Homo sapiens	49-53
23715767-7	2013	Suppression of Egr-1 expression by siRNA abrogated the ability of TPA to induce Egr-1 and JNK-1 activities, moderately increasing the p21 activity and abrogating the anti-apoptotic effect of Egr-1 observed in the prostate cancer cell lines.	Tetradecanoylphorbol Acetate	66-69	early growth response 1	Homo sapiens	80-85
23786520-6	2013	Moreover, pretreatment with 1 suppressed TPA-triggered induction of NOX2 and membrane translocation of p47(phox).	Tetradecanoylphorbol Acetate	41-44	pleckstrin	Homo sapiens	103-106
11042347-11	2000	The synergistic effect of PMA on IFN-gamma-induced IRF-1 binding activity was observed in macrophage cell line J774 cells as well as RAW 264.7 cells, but not in thioglycollate-elicited peritoneal macrophages.	Tetradecanoylphorbol Acetate	26-29	interferon regulatory factor 1	Mus musculus	51-56
11603298-9	2000	FI0-c 4 mg/L downregulated high-dose LPS- and PMA-induced IL-1 alpha or TNF alpha mRNA and their protein production by THP-1 cells.	Tetradecanoylphorbol Acetate	46-49	interleukin 1 alpha	Homo sapiens	58-68
23055378-5	2013	Tumours in AAILE + DMBA/TPA group exhibited low PCNA and cyclin D1 expression and enhanced expression of p53 and p21 in comparison to the DMBA/TPA group.	Tetradecanoylphorbol Acetate	24-27	transformation related protein 53, pseudogene	Mus musculus	105-108
11121152-3	2000	Using reporter gene (chloramphenicol acetyl transferase) analysis, a minimal granulocyte/macrophage colony-stimulating factor promoter was shown to confer constitutive and phorbol-myristate-acetate-induced regulation of transcriptional activity in keratinocytes, and significantly higher levels of chloramphenicol acetyl transferase activity were measured in lysates of unstimulated and phorbol-myristate-acetate-treated atopic dermatitis keratinocytes than in control keratinocyte cultures.	Tetradecanoylphorbol Acetate	172-197	colony stimulating factor 2	Homo sapiens	77-125
11033016-3	2000	In vitro stimulation of IFN-gamma production required incubation of splenocytes with PMA and ionomycin in the presence of the protein transport inhibitor brefeldin A for 6 h. Three stimulation protocols for IL-4 and IL-10 production were evaluated.	Tetradecanoylphorbol Acetate	85-88	interferon gamma	Rattus norvegicus	24-33
23463138-5	2013	Fluorescence activated cell sorting results indicated that Th cells were the main source of IL-5 in the T cell population after phorbol 12-myristate 13-acetate and ionomycin stimulation.	Tetradecanoylphorbol Acetate	128-159	interleukin 5	Mus musculus	92-96
11009442-6	2000	NHE-1 inhibition attenuated both phorbol 12-myristate 13-acetate- and platelet-activating factor-induced neutrophil respiratory burst but not CD18 upregulation.	Tetradecanoylphorbol Acetate	33-64	solute carrier family 9 member A1	Canis lupus familiaris	0-5
11023549-10	2000	These results suggested that tyrosinase-dependent oxidative metabolism of PA was at least partially involved in the enhanced effects of PA on TPA-induced inflammatory responses and thus tumor promotion.	Tetradecanoylphorbol Acetate	142-145	tyrosinase	Mus musculus	29-39
11093788-10	2000	Dominant-negative PKCalpha, NIK, or IKK2, but not IKK1 mutant, inhibited IL-1beta- or TPA-induced ICAM-1 promoter activity.	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	28-31
11093788-10	2000	Dominant-negative PKCalpha, NIK, or IKK2, but not IKK1 mutant, inhibited IL-1beta- or TPA-induced ICAM-1 promoter activity.	Tetradecanoylphorbol Acetate	86-89	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	36-40
10970902-5	2000	The NF-kappaB binding site from the mouse TERT promoter activated transcription when fused to a basal SV40 promoter and enhanced the activity of the native TERT promoter in mouse hepatoma cells stimulated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	210-241	telomerase reverse transcriptase	Mus musculus	42-46
10970902-5	2000	The NF-kappaB binding site from the mouse TERT promoter activated transcription when fused to a basal SV40 promoter and enhanced the activity of the native TERT promoter in mouse hepatoma cells stimulated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	210-241	telomerase reverse transcriptase	Mus musculus	156-160
10936665-3	2000	The expression of IA-2/PTP35 messages was detected by northern blot analysis in MIN6N8 cells, an insulinoma cell line derived from non-obese diabetic mice, but its expression level was not affected by the ambient glucose level, phorbol-12-myristate 13-acetate or tumour necrosis factor-alpha.	Tetradecanoylphorbol Acetate	228-259	protein tyrosine phosphatase, receptor type, N	Mus musculus	18-22
23671446-9	2013	At concentrations of 5, 10 and 20 microM, it was significantly inhibited the PMA-induced expressions of MMP-1 (2.27 +-0.10, 1.98 +-0.11 and 1.56 +-0.15; p &lt; 0.001) and MMP-13 (0.89 +-0.04, 0.81 +-0.07, and 0.74 +-0.09; p &lt; 0.001), respectively.	Tetradecanoylphorbol Acetate	77-80	matrix metallopeptidase 1	Homo sapiens	104-109
10954417-4	2000	Immunofluorescence microscopy revealed a more rapid change in the membrane distribution of ZO-1 compared to occludin in the TPA-treated cells.	Tetradecanoylphorbol Acetate	124-127	occludin	Sus scrofa	108-116
22689058-10	2013	EVI1 knockdown significantly inhibited the expression of megakaryocytic markers after treating K562 cells with TPA, as happens when knocking down RUNX1.	Tetradecanoylphorbol Acetate	111-114	RUNX family transcription factor 1	Homo sapiens	0-4
10954417-7	2000	Surprisingly, activation of protein kinase C with 10(-7) M TPA resulted in a time-dependent decrease in threonine phosphorylation of occludin which correlated closely with the rapid decrease in transepithelial electrical resistance.	Tetradecanoylphorbol Acetate	59-62	occludin	Sus scrofa	133-141
10954417-8	2000	This dephosphorylation of occludin, occurring after activation of a serine/threonine kinase by TPA, suggested that protein kinase C was not acting directly on this tight junction target protein.	Tetradecanoylphorbol Acetate	95-98	occludin	Sus scrofa	26-34
11041200-3	2000	In the present study, we showed that inhibition of protein phosphatases (PP-1 and PP-2a) prevented the TPA-induced differentiation in ML-1 cells.	Tetradecanoylphorbol Acetate	103-106	protein phosphatase 2 phosphatase activator	Homo sapiens	82-87
11041200-4	2000	Preinhibition of PP-1 and PP-2a activities with 1-100 nM okadaic acid dose-dependently blunted the decrease in the phosphorylation status of pRb obtained with TPA and overrode cell cycle arrest.	Tetradecanoylphorbol Acetate	159-162	protein phosphatase 2 phosphatase activator	Homo sapiens	26-31
11082532-3	2000	Daunorubicin, as well as sphingomyelinase (SMase) and the exogenous cell-permeable ceramide analogue C(2)-ceramide, inhibited phospholipase D activity stimulated by phorbol 12-myristate 13-acetate or epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	165-196	epidermal growth factor	Homo sapiens	200-223
11082532-3	2000	Daunorubicin, as well as sphingomyelinase (SMase) and the exogenous cell-permeable ceramide analogue C(2)-ceramide, inhibited phospholipase D activity stimulated by phorbol 12-myristate 13-acetate or epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	165-196	epidermal growth factor	Homo sapiens	225-228
23613866-4	2013	In contrast, treatment with interleukin-1beta (IL-1beta) or phorbol-12-myristate-13-acetate (PMA) increased the level of Thy-1 protein and reduced the migration of HUVEC.	Tetradecanoylphorbol Acetate	60-91	Thy-1 cell surface antigen	Homo sapiens	121-126
11073843-6	2000	Only intracellular IL-1ra type I mRNA was detected in human umbilical vein ECs (HUVECs) and human coronary artery ECs (HCAECs) when they were stimulated with bacterial lipopolysaccharide/phorbol myristate acetate and transforming growth factor-beta.	Tetradecanoylphorbol Acetate	187-212	interleukin 1 receptor antagonist	Homo sapiens	19-25
11050045-6	2000	Interestingly, Elk-1 activities were further enhanced by the tumor promoter, 12-O-tetradecanoyl phorbol 13-acetate (TPA), but not by hepatocyte mitogens (epidermal growth factor [EGF] and transforming growth factor alpha [TGF-alpha]) in NIH3T3 cells and HepG2 cells expressing HCV core protein.	Tetradecanoylphorbol Acetate	77-114	ELK1, member of ETS oncogene family	Mus musculus	15-20
10940935-0	2000	Requirement for integration of phorbol 12-myristate 13-acetate and calcium pathways is preserved in the transactivation domain of NFAT1.	Tetradecanoylphorbol Acetate	31-62	nuclear factor of activated T cells 2	Homo sapiens	130-135
11050045-6	2000	Interestingly, Elk-1 activities were further enhanced by the tumor promoter, 12-O-tetradecanoyl phorbol 13-acetate (TPA), but not by hepatocyte mitogens (epidermal growth factor [EGF] and transforming growth factor alpha [TGF-alpha]) in NIH3T3 cells and HepG2 cells expressing HCV core protein.	Tetradecanoylphorbol Acetate	116-119	ELK1, member of ETS oncogene family	Mus musculus	15-20
23613866-4	2013	In contrast, treatment with interleukin-1beta (IL-1beta) or phorbol-12-myristate-13-acetate (PMA) increased the level of Thy-1 protein and reduced the migration of HUVEC.	Tetradecanoylphorbol Acetate	93-96	Thy-1 cell surface antigen	Homo sapiens	121-126
23720884-4	2013	AAILE treatment decreased the DMBA/TPA-induced increase in cutaneous CYP level and enhanced the DTD and UDP-GT activities when compared with DMBA/TPA group.	Tetradecanoylphorbol Acetate	35-38	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	69-72
11069615-7	2000	Treatment of these double transgenic mice with 12-O-tetradecanoyl-phorbol-13-acetate caused rapid migration of beta-galactosidase marked cells from the hair follicle through the interfollicular epidermis, demonstrating the usefulness of this specific double transgenic for fate mapping cells in the epidermis.	Tetradecanoylphorbol Acetate	47-84	galactosidase, beta 1	Mus musculus	111-129
10903772-9	2000	PMA-induced GM-CSF production in HBECs did not require a Ca2+ ionophore and was not inhibited by cyclosporin A.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 2	Homo sapiens	12-18
10903772-10	2000	Activation of MAPKerk1/2 via PKC was associated with and was required for GM-CSF production induced by PMA and TNF-alpha.	Tetradecanoylphorbol Acetate	103-106	colony stimulating factor 2	Homo sapiens	74-80
10947075-3	2000	In contrast, the chronic treatment with PMA increased the expression of PKCepsilon and PKCzeta.	Tetradecanoylphorbol Acetate	40-43	protein kinase C epsilon	Homo sapiens	72-82
23237270-1	2013	Time-dependent density functional theory (TD-DFT) was employed to calculate the UV/vis spectra for three of the triphenylamine (TPA)-donor dyes, TC1, L1, and LJ1, in isolation as well as when complexed with a titania nanoparticle.	Tetradecanoylphorbol Acetate	128-131	transcobalamin 1	Homo sapiens	145-148
10777489-3	2000	However, while MCL1 phosphorylation induced by the protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), did not affect its electrophoretic mobility, microtubule-damaging agents, such as taxol, induced MCL1 phosphorylation associated with a band shift to decreased mobility.	Tetradecanoylphorbol Acetate	79-115	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	15-19
10777489-3	2000	However, while MCL1 phosphorylation induced by the protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), did not affect its electrophoretic mobility, microtubule-damaging agents, such as taxol, induced MCL1 phosphorylation associated with a band shift to decreased mobility.	Tetradecanoylphorbol Acetate	117-120	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	15-19
10777489-4	2000	Inhibitors of extracellular signal-regulated kinase (ERK) activation blocked TPA-induced MCL1 phosphorylation but not the taxol-induced band shift.	Tetradecanoylphorbol Acetate	77-80	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	89-93
10777489-5	2000	TPA-induced MCL1 phosphorylation occurred rapidly and was not associated with decreased viability, while the taxol-induced band shift occurred upon extended exposure as cells accumulated in G(2)/M followed by cell death.	Tetradecanoylphorbol Acetate	0-3	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	12-16
10777489-7	2000	Thus, MCL1 undergoes two distinct types of phosphorylation: (i) TPA-induced, ERK-associated phosphorylation, which does not alter the electrophoretic mobility of MCL1, and (ii) ERK-independent phosphorylation, which results in an MCL1 band shift and is induced by events in G(2)/M or protein phosphatase 1/2A inhibitors.	Tetradecanoylphorbol Acetate	64-67	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	6-10
11044097-6	2000	Consistent with this observation, using nuclear extracts prepared from Jurkat T cells, we show that HMG I (but not HMG Y) is strongly induced upon phorbol myristate acetate stimulation and this induced HMG I appears to both selectively inhibit the binding of basal DNA-binding proteins and enhance the binding of an inducible AP-1 transcription factor to this AP-1 binding site.	Tetradecanoylphorbol Acetate	147-172	high mobility group AT-hook 1	Homo sapiens	100-105
11086176-4	2000	However, differentiation of K562 cells with 12-O-tetradecanoylphorbol 13-acetate, modeling aspects of megakaryopoiesis, was partially inhibited by the persistent expression of both the murine + / + and - / - WT1 isoforms.	Tetradecanoylphorbol Acetate	44-80	WT1 transcription factor	Mus musculus	208-211
10918054-1	2000	Treatment of human promyelocytic leukemia cells (HL-60) with phorbol 12-myristate 13-acetate (PMA) is known to decrease c-myc mRNA by blocking transcription elongation at sites near the first exon/intron border.	Tetradecanoylphorbol Acetate	61-92	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	120-125
10918054-1	2000	Treatment of human promyelocytic leukemia cells (HL-60) with phorbol 12-myristate 13-acetate (PMA) is known to decrease c-myc mRNA by blocking transcription elongation at sites near the first exon/intron border.	Tetradecanoylphorbol Acetate	94-97	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	120-125
10918054-4	2000	Treatment with PMA or bryostatin 1 increased nuclear protein binding to MIE1, a c-myc intron 1 element that defines an RFX1-binding X box.	Tetradecanoylphorbol Acetate	15-18	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	80-85
10884289-5	2000	TPA treatment of infected adipocytes increased luciferase activity, consistent with previous studies indicating that the KLBP/FABP5 gene is up-regulated by phorbol esters.	Tetradecanoylphorbol Acetate	0-3	fatty acid binding protein 5, epidermal	Mus musculus	126-131
23390568-8	2013	In contrast, treatment of these groups with TPA alone indicates that Cav1 KO mice are more susceptible to promoter treatment as evidenced by increased epidermal proliferation.	Tetradecanoylphorbol Acetate	44-47	caveolin 1, caveolae protein	Mus musculus	69-73
10871841-13	2000	This work shows that annexin V overexpression suppresses the TPA-induced Ras/ERK signaling by inhibiting at/or upstream of Shc, possibly through the inhibition of PKCs.	Tetradecanoylphorbol Acetate	61-64	annexin A5	Homo sapiens	21-30
10838159-4	2000	15-PGDH activity was found to be optimally induced by phorbol 12-myristate 13-acetate (PMA) at 10 nM after 24 h of treatment.	Tetradecanoylphorbol Acetate	54-85	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	0-7
10838159-4	2000	15-PGDH activity was found to be optimally induced by phorbol 12-myristate 13-acetate (PMA) at 10 nM after 24 h of treatment.	Tetradecanoylphorbol Acetate	87-90	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	0-7
11018526-1	2000	The tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 2 (PAI-2) genes are differentially regulated by 12-phorbol 13-myristate acetate (PMA) in HT-1080 fibrosarcoma cells.	Tetradecanoylphorbol Acetate	167-170	serpin family B member 2	Homo sapiens	49-87
11018526-1	2000	The tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 2 (PAI-2) genes are differentially regulated by 12-phorbol 13-myristate acetate (PMA) in HT-1080 fibrosarcoma cells.	Tetradecanoylphorbol Acetate	167-170	serpin family B member 2	Homo sapiens	89-94
24018669-1	2013	This study shows that the ECM degradation-associated pathway, including uPA and tPA and the downstream MMP-2/-9 protein, was significantly suppressed in HA22T cells treated with a Zanthoxylum avicennae extract (YBBE).	Tetradecanoylphorbol Acetate	80-83	multimerin 1	Homo sapiens	26-29
10871606-2	2000	12-O-Tetradecanoylphorbol-13-acetate (TPA) induction of the FGF-BP gene occurs through transcriptional mechanisms involving Sp1, AP-1, and CCAATT/enhancer-binding protein sites in the proximal FGF-BP gene promoter.	Tetradecanoylphorbol Acetate	0-36	fibroblast growth factor binding protein 1	Homo sapiens	60-66
10871606-2	2000	12-O-Tetradecanoylphorbol-13-acetate (TPA) induction of the FGF-BP gene occurs through transcriptional mechanisms involving Sp1, AP-1, and CCAATT/enhancer-binding protein sites in the proximal FGF-BP gene promoter.	Tetradecanoylphorbol Acetate	0-36	fibroblast growth factor binding protein 1	Homo sapiens	193-199
10838159-9	2000	Either induction by PMA or inhibition by dexamethasone the 15-PGDH activity correlated well with the enzyme protein expression as shown by the Western blot analysis.	Tetradecanoylphorbol Acetate	20-23	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	59-66
10839933-11	2000	At concentrations used clinically, pentobarbital inhibited the accumulation of HSP27 by vasopressin or TPA.	Tetradecanoylphorbol Acetate	103-106	heat shock protein family B (small) member 1	Homo sapiens	79-84
10871606-2	2000	12-O-Tetradecanoylphorbol-13-acetate (TPA) induction of the FGF-BP gene occurs through transcriptional mechanisms involving Sp1, AP-1, and CCAATT/enhancer-binding protein sites in the proximal FGF-BP gene promoter.	Tetradecanoylphorbol Acetate	38-41	fibroblast growth factor binding protein 1	Homo sapiens	60-66
10849009-4	2000	Recently, we reported that the transcriptional activity of BZLF1 is augmented by TPA [Baumann, M., Mischak, H., Dammeier, S., Kolch, W., Gires, O., Pich, D., Zeidler, R., Delecluse, H. J.	Tetradecanoylphorbol Acetate	81-84	protein Zta	Human gammaherpesvirus 4	59-64
23000424-8	2013	Mith significantly suppressed TPA-induced neoplastic cell transformation through the down-regulation of the Mcl-1 protein in JB6 cells, and suppressed the transforming activity of both cell types.	Tetradecanoylphorbol Acetate	30-33	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	108-113
10849009-7	2000	The increase of BZLF1"s activity depends on a single serine residue (S186) that is phosphorylated by protein kinase C (PKC) in vitro and in vivo after stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	168-204	protein Zta	Human gammaherpesvirus 4	16-21
10849009-7	2000	The increase of BZLF1"s activity depends on a single serine residue (S186) that is phosphorylated by protein kinase C (PKC) in vitro and in vivo after stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	206-209	protein Zta	Human gammaherpesvirus 4	16-21
10849366-8	2000	The levels of c-Myc and Mad1 mRNAs and proteins increased within 3 h of anti-mu stimulation, and the levels were further enhanced by TPA.	Tetradecanoylphorbol Acetate	133-136	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	14-19
10849366-9	2000	Furthermore, the expressions of both c-Myc and Mad1 were reduced by forskolin, which also inhibited the anti-mu + TPA driven growth and differentiation of the B lymphocytes.	Tetradecanoylphorbol Acetate	114-117	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	37-42
10871606-2	2000	12-O-Tetradecanoylphorbol-13-acetate (TPA) induction of the FGF-BP gene occurs through transcriptional mechanisms involving Sp1, AP-1, and CCAATT/enhancer-binding protein sites in the proximal FGF-BP gene promoter.	Tetradecanoylphorbol Acetate	38-41	fibroblast growth factor binding protein 1	Homo sapiens	193-199
10871606-9	2000	In vitro gel shift analysis revealed distinct and TPA-dependent binding of USF1 and USF2 to the repressor element that required nucleotides within the E-box.	Tetradecanoylphorbol Acetate	50-53	upstream transcription factor 1	Homo sapiens	75-79
10893420-7	2000	Here we show that several neutrophil agonists (phorbol myristate acetate, opsonized zymosan, and N-formyl-methionyl-leucyl-phenylalanine) induce p22(phox) phosphorylation in intact neutrophils.	Tetradecanoylphorbol Acetate	47-72	calcineurin like EF-hand protein 1	Homo sapiens	145-148
23451083-15	2013	Both telmisartan and candesartan did not inhibit TPA-induced EGFR phosphorylation, and telmisartan, but not candesartan, inhibited TPA-induced nuclear translocation of HB-EGF-CTF after knockdown of AT1R.	Tetradecanoylphorbol Acetate	131-134	heparin binding EGF like growth factor	Homo sapiens	168-174
10893420-9	2000	Phorbol myristate acetate-induced phosphorylation of p22(phox) and NADPH oxidase activity were not reduced by ethanol.	Tetradecanoylphorbol Acetate	0-25	calcineurin like EF-hand protein 1	Homo sapiens	53-56
10993214-2	2000	It was observed that O2- generation of intact and GCSF-treated neutrophils by PMA-stimulation showed a lag during the early stage, and was largely inhibited by 1-(5-isoquinoline-sulfonyl)-3-methyl-piperazine (200 microm) or GF109203X (GFX) (0.2 microM), but not by ethanol (1%) and wortmannin (100 nM).	Tetradecanoylphorbol Acetate	78-81	colony stimulating factor 3	Homo sapiens	50-54
10993214-4	2000	Although translocation of p47phox and p67phox to the membrane fraction by PMA-stimulation of intact and GCSF-treated neutrophils occurred in parallel with O2- production, that of CB-treated neutrophils by PMA-stimulation was not always proportional to O2- production.	Tetradecanoylphorbol Acetate	74-77	colony stimulating factor 3	Homo sapiens	104-108
10896239-1	2000	The present investigation was undertaken to explore the effect of platelets, tumor necrosis factor (TNF) and phorbel ester [phorbol 12-myristate 13-acetate (PMA)] on lipopolysaccharide (LPS)-induced tissue factor (TF) activity and TF antigen by using Western blot and ELISA-techniques.	Tetradecanoylphorbol Acetate	124-155	coagulation factor III, tissue factor	Homo sapiens	199-212
10896239-1	2000	The present investigation was undertaken to explore the effect of platelets, tumor necrosis factor (TNF) and phorbel ester [phorbol 12-myristate 13-acetate (PMA)] on lipopolysaccharide (LPS)-induced tissue factor (TF) activity and TF antigen by using Western blot and ELISA-techniques.	Tetradecanoylphorbol Acetate	124-155	coagulation factor III, tissue factor	Homo sapiens	214-216
10809755-10	2000	Double immunostaining studies also indicated that newly expressed RPTPbeta colocalized with VacA in PMA-treated HL-60 cells.	Tetradecanoylphorbol Acetate	100-103	protein tyrosine phosphatase receptor type Z1	Homo sapiens	66-74
23105093-6	2012	Both supershift and ChIP assays revealed the presence of the AP-1 component c-JUN at the PED/PEA-15 promoter upon 12-O-tetradecanoylphorbol-13-acetate stimulation of the cells.	Tetradecanoylphorbol Acetate	114-150	proliferation and apoptosis adaptor protein 15A	Mus musculus	93-99
10799876-4	2000	In contrast, macrophages from p47phox -/- (pKO) mice, which lack functional NADPH oxidase, retained their NO-dependent inhibition of T cell proliferation upon stimulation with PMA, indicating that NADPH oxidase is the major source of NO-inactivating O2- in this system.	Tetradecanoylphorbol Acetate	176-179	neutrophil cytosolic factor 1	Mus musculus	30-37
23041978-0	2012	Effects of 12-O-tetradecanoylphorbol-13-acetate in combination with             gemcitabine on Panc-1 pancreatic cancer cells cultured in vitro or Panc-1 tumors             grown in immunodeficient mice.	Tetradecanoylphorbol Acetate	11-47	pancreas protein 1	Mus musculus	95-101
11042674-7	2000	Accordingly, PKC activation by TPA treatment was associated with a significant expression of the cdk/cyclin inhibitor p21WAF/CIP/sdi-1 in the adherent population and subsequent G0/G1 cell cycle arrest.	Tetradecanoylphorbol Acetate	31-34	proliferating cell nuclear antigen	Homo sapiens	101-107
23123091-0	2012	Involvement of PTEN in TPA-mediated p53-activation in mouse skin epidermal JB6 cells.	Tetradecanoylphorbol Acetate	23-26	transformation related protein 53, pseudogene	Mus musculus	36-39
11042674-11	2000	In this context, incubation with the caspase-3/caspase-7 specific tetrapeptide inhibitor DEVD prior to TPA treatment prevented an accumulation of cells in subG1, respectively, demonstrating an involvement of these caspases.	Tetradecanoylphorbol Acetate	103-106	caspase 7	Homo sapiens	47-56
10946308-4	2000	Human neutrophils, monocytes, and eosinophils were all demonstrated to have significant surface expression of PSGL-1 at baseline, which decreased within minutes of exposure to PAF or PMA.	Tetradecanoylphorbol Acetate	183-186	selectin P ligand	Homo sapiens	110-116
10793091-3	2000	When monocytes/macrophages were subjected to 4% strain at 1 Hz for 24 hours, neither matrix metalloproteinase (MMP)-1 nor MMP-3 was induced; however, in the presence of phorbol myristate acetate, strain augmented MMP-1 expression by 5.1 +/- 0.7-fold (P &lt; 0.05) and MMP-3 expression by 1.	Tetradecanoylphorbol Acetate	169-194	matrix metallopeptidase 1	Homo sapiens	213-218
10811002-7	2000	Moreover, pretreatment of the cells with the protein kinase C (PKC) inhibitors GF-109203X and RO-31-8220 and down-regulation of PKCalpha by prolonged treatment with 4beta-phorbol 12-myristate 13-acetate inhibited the H2O2-stimulated PLD2 activity, which points to the involvement of PKCalpha.	Tetradecanoylphorbol Acetate	165-202	phospholipase D2	Mus musculus	233-237
23123091-2	2012	However, how p53 activation is regulated during TPA treatment remains elusive.	Tetradecanoylphorbol Acetate	48-51	transformation related protein 53, pseudogene	Mus musculus	13-16
23123091-3	2012	We used murine skin epidermal JB6 promotion-sensitive (P+) and promotion resistant (P-) cells to observe differential expression of PTEN during TPA-induced p53 activation.	Tetradecanoylphorbol Acetate	144-147	transformation related protein 53, pseudogene	Mus musculus	156-159
10786671-5	2000	We show here that the down-regulation of hTERT mRNA during 12-O-tetradecanoylphorbol-13-acetate-induced differentiation of human U937 cells is a consequence of a fast decrease in the rate of transcription rather than changes in its half-life.	Tetradecanoylphorbol Acetate	59-95	telomerase reverse transcriptase	Homo sapiens	41-46
10971817-3	2000	The secretion of both forms of GnRH was increased in a dependent manner during depolarization by high K+ solutions, and was stimulated by forskolin and 12-O-tetradecanoylphorbol-13-acetate (TPA), activators of adenylate cyclase and protein kinase C pathways, respectively.	Tetradecanoylphorbol Acetate	152-188	gonadotropin releasing hormone 1	Rattus norvegicus	31-35
23123091-5	2012	Nuclear expression of PTEN increased and complex formation between PTEN and p53 occurred in P+ cells treated with TPA.	Tetradecanoylphorbol Acetate	114-117	transformation related protein 53, pseudogene	Mus musculus	76-79
10971817-3	2000	The secretion of both forms of GnRH was increased in a dependent manner during depolarization by high K+ solutions, and was stimulated by forskolin and 12-O-tetradecanoylphorbol-13-acetate (TPA), activators of adenylate cyclase and protein kinase C pathways, respectively.	Tetradecanoylphorbol Acetate	190-193	gonadotropin releasing hormone 1	Rattus norvegicus	31-35
10753934-1	2000	Stimulation of serum-starved human embryonic kidney (HEK) 293 cells with either the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), or insulin resulted in increases in the phosphorylation of 4E-BP1 and p70 S6 kinase, eIF4F assembly, and protein synthesis.	Tetradecanoylphorbol Acetate	99-135	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	202-208
23123091-9	2012	Our findings suggest PTEN mediates TPA-induced p53 activation.	Tetradecanoylphorbol Acetate	35-38	transformation related protein 53, pseudogene	Mus musculus	47-50
10753934-1	2000	Stimulation of serum-starved human embryonic kidney (HEK) 293 cells with either the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), or insulin resulted in increases in the phosphorylation of 4E-BP1 and p70 S6 kinase, eIF4F assembly, and protein synthesis.	Tetradecanoylphorbol Acetate	137-140	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	202-208
10972227-7	2000	The effect of phorbol 12-myristate 13-acetate and various cytokines on the expression of MCP and CD59 and C-susceptibility was assessed.	Tetradecanoylphorbol Acetate	14-45	membrane cofactor protein	Sus scrofa	89-92
22927445-9	2012	PMA-induced enhancement of STAT3 phosphorylation was observed only in IL-32alpha-expressing cells, and this enhancement was inhibited by Ro-31-8220, but not by Go6976.	Tetradecanoylphorbol Acetate	0-3	interleukin 32	Homo sapiens	70-80
10972227-7	2000	The effect of phorbol 12-myristate 13-acetate and various cytokines on the expression of MCP and CD59 and C-susceptibility was assessed.	Tetradecanoylphorbol Acetate	14-45	CD59 molecule	Sus scrofa	97-101
10972227-13	2000	Increase of C-resistance and of expression of pig MCP, but not of CD59, was achieved upon incubation with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	106-137	membrane cofactor protein	Sus scrofa	50-53
10947068-6	2000	Furthermore, inhibition of TNF-alpha/beta and IL-1alpha/beta, together with CD40 ligand, failed to inhibit EC activation by resting T cells and only inhibited the response to PMA- and ionomycin-activated T cells by 40 +/- 18%.	Tetradecanoylphorbol Acetate	175-178	interleukin 1 alpha	Homo sapiens	46-55
10739671-5	2000	Upon TPA-induced differentiation, c-myb expression was readily down-modulated in parental HL 60 cells, but not in cells transfected with an antisense IRF-1 plasmid.	Tetradecanoylphorbol Acetate	5-8	MYB proto-oncogene, transcription factor	Homo sapiens	34-39
10739673-5	2000	Downregulation of c-myc mRNA and upregulation of c-fos and egr-1 mRNA and protein, which normally occur during TPA-induced differentiation, were not affected by inclusion of the protease inhibitors.	Tetradecanoylphorbol Acetate	111-114	early growth response 1	Homo sapiens	59-64
22578170-16	2012	Moreover, IL-31RA and beta-endorphin were increased and colocalized both in AD human skin and TPA-painted mouse skin.	Tetradecanoylphorbol Acetate	94-97	interleukin 31 receptor A	Homo sapiens	10-17
10780325-0	2000	Lack of tPA significantly affects antithrombotic therapy by a GPIIb/IIIa antagonist, but not by a thrombin inhibitor in mice.	Tetradecanoylphorbol Acetate	8-11	integrin alpha 2b	Mus musculus	62-67
10780325-8	2000	In conclusion, the antithrombotic effect of platelet inhibition by a GPIIb/IIIa antagonist, is severely affected by the absence or presence of tPA-production.	Tetradecanoylphorbol Acetate	143-146	integrin alpha 2b	Mus musculus	69-74
10699487-6	2000	Our data show that the syndecan-1 and glypican-1 mRNA expression is increased by the phorbol myristate acetate (PMA) suggesting a regulation of their expression by the phosphatidyl inositol pathway, as previously hypothesized (Fagen et al., Biochim.	Tetradecanoylphorbol Acetate	85-110	syndecan 1	Rattus norvegicus	23-33
22578802-4	2012	BAPTA-AM inhibited the production and mRNA expression of TSLP in phorbol myristate acetate plus A23187- stimulated HMC-1 cells.	Tetradecanoylphorbol Acetate	65-90	thymic stromal lymphopoietin	Homo sapiens	57-61
10699487-6	2000	Our data show that the syndecan-1 and glypican-1 mRNA expression is increased by the phorbol myristate acetate (PMA) suggesting a regulation of their expression by the phosphatidyl inositol pathway, as previously hypothesized (Fagen et al., Biochim.	Tetradecanoylphorbol Acetate	112-115	syndecan 1	Rattus norvegicus	23-33
10723128-8	2000	We further find that the FAP1 site binds ATF1 and CREB from HeLa nuclear extracts and that the phosphorylation of these factors is induced by TPA.	Tetradecanoylphorbol Acetate	142-145	activating transcription factor 1	Homo sapiens	41-45
10922477-1	2000	Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130.	Tetradecanoylphorbol Acetate	90-93	interleukin 6 cytokine family signal transducer	Homo sapiens	419-424
10922477-2	2000	In this study, we demonstrate that PMA inhibits STAT activation by IL-6 and the related cytokine leukemia inhibitory factor (LIF) but not by oncostatin M (OSM).	Tetradecanoylphorbol Acetate	35-38	LIF interleukin 6 family cytokine	Homo sapiens	97-123
10908728-0	2000	Annexin-I inhibits PMA-induced c-fos SRE activation by suppressing cytosolic phospholipase A2 signal.	Tetradecanoylphorbol Acetate	19-22	phospholipase A2 group IVA	Rattus norvegicus	67-93
22733205-4	2012	We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells.	Tetradecanoylphorbol Acetate	49-74	interleukin 4	Mus musculus	99-112
10940203-6	2000	Interleukin (IL)-1 and phorbol 12-myristate 13-acetate (PMA) induced shedding of TNFRI from ED27 and primary cells suggesting that under inflammatory conditions the soluble receptor protein may protect from cytotoxic effects of TNF-alpha.	Tetradecanoylphorbol Acetate	23-54	TNF receptor superfamily member 1A	Homo sapiens	81-86
10688817-5	2000	The target for this inhibition was Jak2, and the activation of PKC by 12-O-tetradecanoyl-phorbol-13-acetate treatment also abrogated IL-3-induced tyrosine phosphorylation of Jak2 in Ba/F3 cells.	Tetradecanoylphorbol Acetate	70-107	Janus kinase 2	Mus musculus	174-178
10754388-2	2000	We demonstrated that an Sp1 binding site, located between -280 and -275 bp relative to the translational start site (+1) of the FasL gene, was important for the transcription of the FasL gene by deletion and mutation analysis in Jurkat cells after phorbol 12-myristate 13-acetate (PMA) and ionomycin treatment.	Tetradecanoylphorbol Acetate	248-279	Fas ligand	Homo sapiens	128-132
10940203-6	2000	Interleukin (IL)-1 and phorbol 12-myristate 13-acetate (PMA) induced shedding of TNFRI from ED27 and primary cells suggesting that under inflammatory conditions the soluble receptor protein may protect from cytotoxic effects of TNF-alpha.	Tetradecanoylphorbol Acetate	56-59	TNF receptor superfamily member 1A	Homo sapiens	81-86
10754388-2	2000	We demonstrated that an Sp1 binding site, located between -280 and -275 bp relative to the translational start site (+1) of the FasL gene, was important for the transcription of the FasL gene by deletion and mutation analysis in Jurkat cells after phorbol 12-myristate 13-acetate (PMA) and ionomycin treatment.	Tetradecanoylphorbol Acetate	248-279	Fas ligand	Homo sapiens	182-186
22733205-4	2012	We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells.	Tetradecanoylphorbol Acetate	49-74	interleukin 4	Mus musculus	114-118
10754388-2	2000	We demonstrated that an Sp1 binding site, located between -280 and -275 bp relative to the translational start site (+1) of the FasL gene, was important for the transcription of the FasL gene by deletion and mutation analysis in Jurkat cells after phorbol 12-myristate 13-acetate (PMA) and ionomycin treatment.	Tetradecanoylphorbol Acetate	281-284	Fas ligand	Homo sapiens	128-132
10754388-2	2000	We demonstrated that an Sp1 binding site, located between -280 and -275 bp relative to the translational start site (+1) of the FasL gene, was important for the transcription of the FasL gene by deletion and mutation analysis in Jurkat cells after phorbol 12-myristate 13-acetate (PMA) and ionomycin treatment.	Tetradecanoylphorbol Acetate	281-284	Fas ligand	Homo sapiens	182-186
22733205-4	2012	We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells.	Tetradecanoylphorbol Acetate	49-74	interleukin 5	Mus musculus	121-125
10928471-4	2000	The drug also reduced PAI-1 antigen secreted in response to 10 microg/ml bacterial lipopolysaccharide (LPS), 100 U/ml tumour necrosis factor alpha (TNFalpha) or 0.1 microM phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	172-197	serpin family E member 1	Homo sapiens	22-27
22733205-4	2012	We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells.	Tetradecanoylphorbol Acetate	76-79	interleukin 4	Mus musculus	99-112
10928471-4	2000	The drug also reduced PAI-1 antigen secreted in response to 10 microg/ml bacterial lipopolysaccharide (LPS), 100 U/ml tumour necrosis factor alpha (TNFalpha) or 0.1 microM phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	199-202	serpin family E member 1	Homo sapiens	22-27
10719041-7	2000	IQ-DNA adducts were also formed in extracellular DNA when phorbol myristate acetate-stimulated neutrophils (which activate IQ via MPO) were co-incubated with IQ (500 microM) and extracellular plasmid (4 +/- 1 adducts/10(8) nucleotides) or calf thymus DNA (6 +/- 2).	Tetradecanoylphorbol Acetate	58-83	myeloperoxidase	Bos taurus	130-133
22733205-4	2012	We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells.	Tetradecanoylphorbol Acetate	76-79	interleukin 4	Mus musculus	114-118
22733205-4	2012	We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells.	Tetradecanoylphorbol Acetate	76-79	interleukin 5	Mus musculus	121-125
22733205-6	2012	In EL-4 T cells, PMA/ionomycin treatment markedly increased the expression of nuclear factor of activated T cells (NFAT) and GATA-3; in contrast, scopoletin significantly down-regulated expressions of these transcription factors.	Tetradecanoylphorbol Acetate	17-20	GATA binding protein 3	Mus musculus	125-131
10674404-4	2000	Western blot analysis revealed that curcumin inhibited phorbol 12-myristate 13-acetate-induced de novo synthesis of Egr-1 protein in endothelial cells.	Tetradecanoylphorbol Acetate	55-86	early growth response 1	Homo sapiens	116-121
22562304-0	2012	TPA-induced cell transformation provokes a complex formation between Pin1 and 90 kDa ribosomal protein S6 kinase 2.	Tetradecanoylphorbol Acetate	0-3	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	69-73
10674404-6	2000	Northern blot analysis showed that curcumin inhibited serum and phorbol 12-myristate 13-acetate induced expression of tissue factor and urokinase-type plasminogen activator receptor mRNA in fibroblasts.	Tetradecanoylphorbol Acetate	64-95	coagulation factor III, tissue factor	Homo sapiens	118-131
10764746-7	2000	In transfected cells, TTRAP inhibits in a dose-dependent manner the transcriptional activation of a nuclear factor-kappaB (NF-kappaB)-dependent reporter mediated by CD40, TNF-R75 or Phorbol 12-myristate 13-acetate (PMA) and to a lesser extent by TRAF2, TRAF6, TNF-alpha, or interleukin-1beta (IL-1beta).	Tetradecanoylphorbol Acetate	182-213	tyrosyl-DNA phosphodiesterase 2	Homo sapiens	22-27
22607136-1	2012	Previous work has demonstrated that phorbol ester (TPA)-induced adherence of human U937 myeloid leukemia cells can be blocked upon down-modulation of the beta2-integrin CD11b after stable transfection of U937 cells with a pMTH1 vector-containing the CD11b gene in antisense orientation (asCD11b-U937) [Otte et al., (2011)].	Tetradecanoylphorbol Acetate	51-54	tubulin beta 4B class IVb	Homo sapiens	154-159
10866321-5	2000	In a transient transfection assay, all three RAR subtypes, RARalpha, RARbeta, and RARgamma, could effectively inhibit phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity and the activity of oncogenes c-Jun and c-Fos on AP-1 containing reporter genes in the presence of retinoic acid (RA).	Tetradecanoylphorbol Acetate	132-168	retinoic acid receptor alpha	Homo sapiens	45-48
10866321-5	2000	In a transient transfection assay, all three RAR subtypes, RARalpha, RARbeta, and RARgamma, could effectively inhibit phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity and the activity of oncogenes c-Jun and c-Fos on AP-1 containing reporter genes in the presence of retinoic acid (RA).	Tetradecanoylphorbol Acetate	132-168	retinoic acid receptor alpha	Homo sapiens	59-67
10662777-3	2000	Actin comet tail formation in vivo was stimulated by the PKC activator phorbol myristate acetate (PMA), and this process could be reconstituted in a cell-free system.	Tetradecanoylphorbol Acetate	71-96	actin like 6A S homeolog	Xenopus laevis	0-5
10662777-3	2000	Actin comet tail formation in vivo was stimulated by the PKC activator phorbol myristate acetate (PMA), and this process could be reconstituted in a cell-free system.	Tetradecanoylphorbol Acetate	98-101	actin like 6A S homeolog	Xenopus laevis	0-5
10737264-7	2000	Stimulation of IL-2 production by the extracts was higher in cultures with PMA/Ca ionophore than in cultures with R73 mAb.	Tetradecanoylphorbol Acetate	75-78	interleukin 2	Rattus norvegicus	15-19
22607136-6	2012	Moreover, adherent pMTH1-U937 demonstrated the expression of monocytic differentiation markers including F4-80 and CD14 and an increased MIP-1alpha production which remained at low or undetectable in TPA-induced asCD11b-U937.	Tetradecanoylphorbol Acetate	200-203	C-C motif chemokine ligand 3	Homo sapiens	137-147
10690956-11	2000	Furthermore, the insulinotropic effect of ET-1 at 16.7 mmol/L glucose was counteracted by the PKC inhibitor Calphostin C (P &lt; .05) and by downregulation of PKC by 24 hours of exposure of islets to TPA (0.5 micromol/L, P &lt; .05).	Tetradecanoylphorbol Acetate	200-203	endothelin 1	Mus musculus	42-46
22672985-8	2012	In CDDP-resistant cells, CDDP and PMA dramatically suppressed the cell growth, up-regulated the expression of phosphorylated ERK and cleaved caspase-9, down-regulated the expression of checkpoint kinases, and increased the proportion of cells in the synthesis-phase fraction and apoptotic cells.	Tetradecanoylphorbol Acetate	34-37	caspase 9	Homo sapiens	141-150
10629034-5	2000	Indeed, the PKC activator phorbol 12-myristate 13-acetate induced Rap1 activation, whereas the PKC-inhibitor bisindolylmaleimide inhibited the second, but not the first, phase of Rap1 activation.	Tetradecanoylphorbol Acetate	26-57	RAP1A, member of RAS oncogene family	Homo sapiens	66-70
10801330-4	2000	12-O-Tetradecanoylphorbol 13-acetate and 1-oleoyl-2-acetyl-sn-glycerol, protein kinase C (PKC) activators, also induced Cas tyrosine phosphorylation, albeit sluggishly.	Tetradecanoylphorbol Acetate	0-36	BCAR1 scaffold protein, Cas family member	Homo sapiens	120-123
10788447-2	2000	In this study, we characterized the intracellular pathways involved in IGF-1-induced activation of Akt and evaluated the effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) on the Akt activation by IGF-1.	Tetradecanoylphorbol Acetate	150-181	insulin-like growth factor 1	Rattus norvegicus	213-218
22381172-0	2012	Berberine suppresses the TPA-induced MMP-1 and MMP-9 expressions through the inhibition of PKC-alpha in breast cancer cells.	Tetradecanoylphorbol Acetate	25-28	matrix metallopeptidase 1	Homo sapiens	37-42
10783130-6	2000	Stable transfection of A549 cells, with GM-CSF promoter/ enhancer constructs containing up to 3.3 kb upstream of the transcription start site, revealed maximal activation by IL-1beta and phorbol 12-myristate 13-acetate (PMA) with a reporter containing the proximal promoter (-627 to +35).	Tetradecanoylphorbol Acetate	187-218	colony stimulating factor 2	Homo sapiens	40-46
10783132-4	2000	Using a protein kinase (PK) C inhibitor, bisindolylmaleimide I, PMA-induced cell cornification and SPRR1 gene expression were abolished.	Tetradecanoylphorbol Acetate	64-67	small proline rich protein 1B	Homo sapiens	99-104
10627456-9	2000	Down-regulation of the PKC-alpha, PKC-beta2, and PKC-epsilon expression by TPA pretreatment, or the down-regulation of PKC-alpha with a specific ribozyme, also inhibited the EPO-induced erythroid differentiation of CD34(+) cells.	Tetradecanoylphorbol Acetate	75-78	protein kinase C epsilon	Homo sapiens	49-60
22381172-9	2012	In contrast, TPA, which is a tumor promoter, significantly increased the levels of the MMP-1 and MMP-9 mRNA and protein expressions in the MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	13-16	matrix metallopeptidase 1	Homo sapiens	87-92
10787437-1	2000	Transcription of the LDL receptor gene is markedly enhanced in the Jurkat T cell line by stimulation with the combination of the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the protein synthesis inhibitor cycloheximide (CHX).	Tetradecanoylphorbol Acetate	143-174	low density lipoprotein receptor	Homo sapiens	21-33
22381172-10	2012	We also observed that the TPA-induced MMP-1 and MMP-9 mRNA and protein expressions were prevented by BBR treatment.	Tetradecanoylphorbol Acetate	26-29	matrix metallopeptidase 1	Homo sapiens	38-43
10787437-1	2000	Transcription of the LDL receptor gene is markedly enhanced in the Jurkat T cell line by stimulation with the combination of the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the protein synthesis inhibitor cycloheximide (CHX).	Tetradecanoylphorbol Acetate	176-179	low density lipoprotein receptor	Homo sapiens	21-33
10769627-3	2000	Exposure to the protein kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H7), increased the phosphorylation of wild type p53 protein, whereas exposure to the tumor promoter phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), decreased it in vivo following 3 hours incubation with mouse epidermal JB6 cells.	Tetradecanoylphorbol Acetate	220-257	transformation related protein 53, pseudogene	Mus musculus	153-156
10769627-3	2000	Exposure to the protein kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H7), increased the phosphorylation of wild type p53 protein, whereas exposure to the tumor promoter phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), decreased it in vivo following 3 hours incubation with mouse epidermal JB6 cells.	Tetradecanoylphorbol Acetate	259-262	transformation related protein 53, pseudogene	Mus musculus	153-156
10769627-5	2000	In the transient transfection/luciferase reporter transactivation assay, H7 modestly increased the mouse double minute (MDM) 2 reporter transactivation activity of p53 protein after 24 hours treatment, and TPA completely blocked it.	Tetradecanoylphorbol Acetate	206-209	transformation related protein 53, pseudogene	Mus musculus	164-167
22381172-11	2012	In addition, the TPA-induced MMP-1 and MMP-9 expressions were completely decreased by Go6983 and PKC-alpha siRNA, respectively.	Tetradecanoylphorbol Acetate	17-20	matrix metallopeptidase 1	Homo sapiens	29-34
22381172-13	2012	CONCLUSION: The TPA-induced PKC-alpha phosphorylation is suppressed and then the MMP-1 and MMP-9 expressions are also inhibited by berberine.	Tetradecanoylphorbol Acetate	16-19	matrix metallopeptidase 1	Homo sapiens	81-86
11023645-6	2000	However, tumor promoter phorbol ester 12-o-tetradecanoyl phorbol-13-acetate (TPA) functioned as a potent inhibitor of both PAcP and PSA expression.	Tetradecanoylphorbol Acetate	38-75	kallikrein related peptidase 3	Homo sapiens	132-135
11023645-6	2000	However, tumor promoter phorbol ester 12-o-tetradecanoyl phorbol-13-acetate (TPA) functioned as a potent inhibitor of both PAcP and PSA expression.	Tetradecanoylphorbol Acetate	77-80	kallikrein related peptidase 3	Homo sapiens	132-135
22511759-5	2012	Despite these data, the levels of the transcripts that encode the proinflammatory cytokines IL-1beta and TNF-alpha were reduced in phorbol 12-myristate 13-acetate-treated MCs developed from RasGRP4-null mice.	Tetradecanoylphorbol Acetate	131-162	RAS guanyl releasing protein 4	Mus musculus	190-197
10655565-3	2000	METHODS: With a three-colour fluorescent labelling technique, specific cytokine production by NK or T cells was visualised directly in whole blood in the same sample after stimulation by phorbol 12-myristate 13-acetate (PMA) and ionomycin and by electronically gating on the CD3-ve/CD56+ve NK population or on the CD3+/CD56+ NK-T-cell population.	Tetradecanoylphorbol Acetate	220-223	neural cell adhesion molecule 1	Homo sapiens	282-286
10655565-3	2000	METHODS: With a three-colour fluorescent labelling technique, specific cytokine production by NK or T cells was visualised directly in whole blood in the same sample after stimulation by phorbol 12-myristate 13-acetate (PMA) and ionomycin and by electronically gating on the CD3-ve/CD56+ve NK population or on the CD3+/CD56+ NK-T-cell population.	Tetradecanoylphorbol Acetate	220-223	neural cell adhesion molecule 1	Homo sapiens	319-323
10749687-7	2000	Furthermore, PMA-induced Pyk2 (and FAK) tyrosine phosphorylation was also observed when platelets adhered to immobilized fibrinogen.	Tetradecanoylphorbol Acetate	13-16	protein tyrosine kinase 2 beta	Homo sapiens	25-29
10753712-3	2000	Immunofluorescence assay in primary PEL cells derived from pericardial effusion and PEL cell lines with and without TPA treatment revealed that primary PEL cells exhibited the same expression pattern as noninduced PEL cell lines, and the treatment changed localization of K8, ORF59, and ORF65 proteins.	Tetradecanoylphorbol Acetate	116-119	ORF65	Human gammaherpesvirus 8	287-292
22447680-1	2012	A series of metal-free acene-modified triphenylamine dyes (benzene to pentacene, denoted as TPA-AC1 to TPA-AC5) are investigated as organic sensitizers for application in dye-sensitized solar cells (DSSCs).	Tetradecanoylphorbol Acetate	92-95	long intergenic non-protein coding RNA 1587	Homo sapiens	96-99
10797562-9	2000	Flow cytometric analyses, blocking adhesion assay using anti-alpha(v) antibody, and co-immunoprecipitation assay all indicated that TPA-treated cells had similar levels of alpha(v) and beta(5) but decreased levels of beta(1) compared with untreated cells and that cell adhesion to OPN is most likely mediated through the alpha(v)beta(5).	Tetradecanoylphorbol Acetate	132-135	secreted phosphoprotein 1	Homo sapiens	281-284
10797562-10	2000	Furthermore, calphostin C, a specific protein kinase C (PKC) inhibitor, decreased TPA-treated JB6 cell adhesion to OPN by 50%, suggesting that TPA increased integrin affinity or avidity for OPN through a PKC-mediated pathway.	Tetradecanoylphorbol Acetate	82-85	secreted phosphoprotein 1	Homo sapiens	115-118
10797562-10	2000	Furthermore, calphostin C, a specific protein kinase C (PKC) inhibitor, decreased TPA-treated JB6 cell adhesion to OPN by 50%, suggesting that TPA increased integrin affinity or avidity for OPN through a PKC-mediated pathway.	Tetradecanoylphorbol Acetate	82-85	secreted phosphoprotein 1	Homo sapiens	190-193
10797562-10	2000	Furthermore, calphostin C, a specific protein kinase C (PKC) inhibitor, decreased TPA-treated JB6 cell adhesion to OPN by 50%, suggesting that TPA increased integrin affinity or avidity for OPN through a PKC-mediated pathway.	Tetradecanoylphorbol Acetate	143-146	secreted phosphoprotein 1	Homo sapiens	115-118
10567848-4	2000	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 20 ng/ ml) caused a marked increase in sodium-dependent L-alanine uptake after both 2 and 16 h of incubation, and the treatment with TPA (20 ng/ml) EGF (20 ng/ml) for 16 h resulted in significant acceleration of the TPA-stimulated increase in L-alanine uptake by LLC-PK1 cells.	Tetradecanoylphorbol Acetate	191-194	epidermal growth factor	Sus scrofa	206-209
10567848-4	2000	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 20 ng/ ml) caused a marked increase in sodium-dependent L-alanine uptake after both 2 and 16 h of incubation, and the treatment with TPA (20 ng/ml) EGF (20 ng/ml) for 16 h resulted in significant acceleration of the TPA-stimulated increase in L-alanine uptake by LLC-PK1 cells.	Tetradecanoylphorbol Acetate	191-194	epidermal growth factor	Sus scrofa	206-209
10567848-5	2000	Coincubation with H-7 (20 microM) inhibited both EGF- and TPA-stimulated increases in L-alanine uptake, and genistein (20 microg/ml) blocked the stimulatory effect of EGF in L-alanine transport to the control level.	Tetradecanoylphorbol Acetate	58-61	epidermal growth factor	Sus scrofa	167-170
10954042-4	2000	Phorbol 12-myristate 13-acetate (PMA), a PKC stimulator, attenuated the cellular uptake of estrone sulfate (ES), a prototype organic anion for rOAT3, in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	0-31	solute carrier family 22 member 8	Rattus norvegicus	143-148
10954042-4	2000	Phorbol 12-myristate 13-acetate (PMA), a PKC stimulator, attenuated the cellular uptake of estrone sulfate (ES), a prototype organic anion for rOAT3, in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	33-36	solute carrier family 22 member 8	Rattus norvegicus	143-148
10797562-10	2000	Furthermore, calphostin C, a specific protein kinase C (PKC) inhibitor, decreased TPA-treated JB6 cell adhesion to OPN by 50%, suggesting that TPA increased integrin affinity or avidity for OPN through a PKC-mediated pathway.	Tetradecanoylphorbol Acetate	143-146	secreted phosphoprotein 1	Homo sapiens	190-193
22447680-5	2012	The results show that from TPA-AC1 to TPA-AC5 with increasing sizes of the acenes, the absorption and fluorescence spectra are systematically broadened and red-shifted, but the oscillator strength and electron injection properties are reduced.	Tetradecanoylphorbol Acetate	27-30	long intergenic non-protein coding RNA 1587	Homo sapiens	31-34
10747287-5	2000	After a single topical treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse skin, Egr-1 mRNA was induced, and maximal induction was observed at 2 h in both epidermis and dermis.	Tetradecanoylphorbol Acetate	57-93	early growth response 1	Mus musculus	122-127
10954042-5	2000	PMA treatment resulted in a decrease in the Vmax, but not the Km of uptake of ES in S2 rOAT3.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 22 member 8	Rattus norvegicus	87-92
10954042-7	2000	Chelerythrine chloride, a PKC inhibitor, reversed the PMA-induced decrease in uptake of ES in S2 rOAT3.	Tetradecanoylphorbol Acetate	54-57	solute carrier family 22 member 8	Rattus norvegicus	97-102
10747287-5	2000	After a single topical treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse skin, Egr-1 mRNA was induced, and maximal induction was observed at 2 h in both epidermis and dermis.	Tetradecanoylphorbol Acetate	95-98	early growth response 1	Mus musculus	122-127
10747287-6	2000	Induction of Egr-1 mRNA by TPA was inhibited by fluocinolone acetonide, a potent inhibitor of tumor promotion by TPA.	Tetradecanoylphorbol Acetate	27-30	early growth response 1	Mus musculus	13-18
22447680-5	2012	The results show that from TPA-AC1 to TPA-AC5 with increasing sizes of the acenes, the absorption and fluorescence spectra are systematically broadened and red-shifted, but the oscillator strength and electron injection properties are reduced.	Tetradecanoylphorbol Acetate	38-41	long intergenic non-protein coding RNA 1587	Homo sapiens	31-34
22447680-6	2012	The molecular orbital contributions show increasing localization on the bridging acene units from TPA-AC1 to TPA-AC5.	Tetradecanoylphorbol Acetate	98-101	long intergenic non-protein coding RNA 1587	Homo sapiens	102-105
10786933-7	2000	Most studies used 12-O-tetradecanoylphorbol-13-acetate (TPA) or ultraviolet (UV) radiation as the tumor promoter and found anticarcinogenic effects caused by green tea polyphenols.	Tetradecanoylphorbol Acetate	18-54	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	164-167
10786933-7	2000	Most studies used 12-O-tetradecanoylphorbol-13-acetate (TPA) or ultraviolet (UV) radiation as the tumor promoter and found anticarcinogenic effects caused by green tea polyphenols.	Tetradecanoylphorbol Acetate	56-59	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	164-167
22447680-6	2012	The molecular orbital contributions show increasing localization on the bridging acene units from TPA-AC1 to TPA-AC5.	Tetradecanoylphorbol Acetate	109-112	long intergenic non-protein coding RNA 1587	Homo sapiens	102-105
10747287-6	2000	Induction of Egr-1 mRNA by TPA was inhibited by fluocinolone acetonide, a potent inhibitor of tumor promotion by TPA.	Tetradecanoylphorbol Acetate	113-116	early growth response 1	Mus musculus	13-18
22330070-2	2012	T cell activation by T cell receptor (TCR) engagement or its pharmacological mimics, PMA plus ionomycin (PMA/Io), induces immunomodulatory FasL and cyclooxygenase-2 (COX-2) expression.	Tetradecanoylphorbol Acetate	85-88	Fas ligand	Homo sapiens	139-143
10601245-6	1999	We observed that disruption of raft integrity by lowering the membrane cholesterol content abolished the CTx and the phorbol 12-myristate 13-acetate-induced LFA-1 binding but left the ability to activate LFA-1 with Mg(2+)/EGTA unimpaired.	Tetradecanoylphorbol Acetate	117-148	integrin alpha L	Mus musculus	157-162
10601319-7	1999	TPA treatment rapidly induced phosphorylation of the CREB-1/ATF-1-like factor via the protein kinase C pathway.	Tetradecanoylphorbol Acetate	0-3	activating transcription factor 1	Homo sapiens	60-65
22125116-3	2012	Zymosan and/or PMA (Phorbol 12-myristate 13-acetate)-induced recruitment of p47(phox) and p67(phox) to the membrane fraction was normal for both mutants.	Tetradecanoylphorbol Acetate	15-18	pleckstrin	Homo sapiens	76-85
10601319-8	1999	These results led us to conclude that the human MnSOD gene having the promoter construct used in this study is induced by TPA via activation of a CREB-1/ATF-1-like factor and not via either NF-kappaB or AP-1.	Tetradecanoylphorbol Acetate	122-125	activating transcription factor 1	Homo sapiens	153-158
10602521-7	1999	Finally, although stimulation of murine fibroblasts with o-tetradecanolylphorbol 13-acetate (TPA), an indirect activator of the MAP kinase pathway, leads to site-specific phosphorylation of murine p53, similar treatment of human fibroblasts and epithelial cells showed no significant changes in the phosphorylation pattern.	Tetradecanoylphorbol Acetate	93-96	transformation related protein 53, pseudogene	Mus musculus	197-200
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Tetradecanoylphorbol Acetate	119-150	selectin L	Homo sapiens	165-175
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Tetradecanoylphorbol Acetate	152-155	selectin L	Homo sapiens	165-175
22125116-3	2012	Zymosan and/or PMA (Phorbol 12-myristate 13-acetate)-induced recruitment of p47(phox) and p67(phox) to the membrane fraction was normal for both mutants.	Tetradecanoylphorbol Acetate	15-18	pleckstrin	Homo sapiens	80-84
10681560-5	2000	The incorporation of Flag-SPRR1 fusion protein into cross-linked envelopes can be demonstrated when transfected human passage 1 TBE cultures are treated with phorbol 12-myristate 13-acetate and high calcium (1.5 mM).	Tetradecanoylphorbol Acetate	158-189	small proline rich protein 1B	Homo sapiens	26-31
22125116-3	2012	Zymosan and/or PMA (Phorbol 12-myristate 13-acetate)-induced recruitment of p47(phox) and p67(phox) to the membrane fraction was normal for both mutants.	Tetradecanoylphorbol Acetate	20-51	pleckstrin	Homo sapiens	76-85
10574959-2	1999	Here we demonstrate that two potent activators of PKC, 12-O-tetradecanoylphorbol-13-acetate and bryostatin, both stimulate phosphorylation of Bad at Ser(112), a site known to regulate apoptotic cell death by interleukin-3.	Tetradecanoylphorbol Acetate	55-91	interleukin 3	Homo sapiens	208-221
22125116-3	2012	Zymosan and/or PMA (Phorbol 12-myristate 13-acetate)-induced recruitment of p47(phox) and p67(phox) to the membrane fraction was normal for both mutants.	Tetradecanoylphorbol Acetate	20-51	pleckstrin	Homo sapiens	80-84
22052014-2	2012	Our earlier studies have shown that mitogenic agent phorbol 12-myristate 13-acetate (PMA) induces the expression of NHE2 through activation of transcription factor early growth response-1 (Egr-1) and its interactions with the NHE2 promoter.	Tetradecanoylphorbol Acetate	52-83	early growth response 1	Homo sapiens	189-194
10595920-8	1999	Immunocytochemical analysis of the cell cycle cyclin-dependent kinase inhibitor p27 showed that treatment with TGF-beta1, forskolin, PMA, and PACAP increased p27 expression in cultured HP75 cells.	Tetradecanoylphorbol Acetate	133-136	interferon alpha inducible protein 27	Homo sapiens	80-83
10648401-2	2000	Platelet stimulation by phorbol 12-myristate 13-acetate (PMA) induced pleckstrin phosphorylation, platelet aggregation, and secretion.	Tetradecanoylphorbol Acetate	24-55	pleckstrin	Homo sapiens	70-80
10648401-2	2000	Platelet stimulation by phorbol 12-myristate 13-acetate (PMA) induced pleckstrin phosphorylation, platelet aggregation, and secretion.	Tetradecanoylphorbol Acetate	57-60	pleckstrin	Homo sapiens	70-80
10595920-8	1999	Immunocytochemical analysis of the cell cycle cyclin-dependent kinase inhibitor p27 showed that treatment with TGF-beta1, forskolin, PMA, and PACAP increased p27 expression in cultured HP75 cells.	Tetradecanoylphorbol Acetate	133-136	interferon alpha inducible protein 27	Homo sapiens	158-161
22052014-2	2012	Our earlier studies have shown that mitogenic agent phorbol 12-myristate 13-acetate (PMA) induces the expression of NHE2 through activation of transcription factor early growth response-1 (Egr-1) and its interactions with the NHE2 promoter.	Tetradecanoylphorbol Acetate	85-88	early growth response 1	Homo sapiens	189-194
22020547-7	2012	Our results showed that the TPA-induced up-regulation             of p21 and down-regulation of p53 was reversed by UO126 (a MEK1/2 inhibitor),             but not by SP600125 (a JNK inhibitor) or SB203580 (a p38 inhibitor), although             TPA increased the phosphorylation of ERK and JNK in MCF-7 cells.	Tetradecanoylphorbol Acetate	246-249	H3 histone pseudogene 16	Homo sapiens	69-72
10600776-3	1999	In the present study, phorbol 12-myristate 13-acetate (PMA) and other activators of PKC selectively enhanced basolateral but not apical fluid-phase endocytosis in human T84 intestinal epithelia.	Tetradecanoylphorbol Acetate	22-53	protein kinase C epsilon	Homo sapiens	84-87
10600776-3	1999	In the present study, phorbol 12-myristate 13-acetate (PMA) and other activators of PKC selectively enhanced basolateral but not apical fluid-phase endocytosis in human T84 intestinal epithelia.	Tetradecanoylphorbol Acetate	55-58	protein kinase C epsilon	Homo sapiens	84-87
10683762-3	1999	The concentrations of cyclin D1 and p21Waf1/Cip1 were dramatically increased, whereas those of cyclin B1 and cdc2 were decreased, by PMA treatment.	Tetradecanoylphorbol Acetate	133-136	cyclin B1	Homo sapiens	95-104
10683762-3	1999	The concentrations of cyclin D1 and p21Waf1/Cip1 were dramatically increased, whereas those of cyclin B1 and cdc2 were decreased, by PMA treatment.	Tetradecanoylphorbol Acetate	133-136	cyclin dependent kinase 1	Homo sapiens	109-113
10679516-7	2000	12-O-tetradecanoylphorbol 13-acetate, an activator of protein kinase C, induced accumulation of HSP27 and was not inhibited by PD98059 but was inhibited by SB203580.	Tetradecanoylphorbol Acetate	0-36	heat shock protein family B (small) member 1	Homo sapiens	96-101
22020547-11	2012	Taken together, we             suggest that TPA reciprocally regulates the level of p21 and p53 expression via             a MEK/ERK-dependent pathway.	Tetradecanoylphorbol Acetate	44-47	H3 histone pseudogene 16	Homo sapiens	84-87
10618646-10	1999	1 microM PMA to activate PKC, which stimulated MCP-1 expression when applied alone, abolished the stimulatory effects of cyclic strain.	Tetradecanoylphorbol Acetate	9-12	C-C motif chemokine ligand 2	Rattus norvegicus	47-52
22020547-12	2012	The up-regulation of p21 in response to TPA is mediated             through a p53-independent mechanism in breast cancer cells.	Tetradecanoylphorbol Acetate	40-43	H3 histone pseudogene 16	Homo sapiens	21-24
10614785-0	1999	P40phox associates with the neutrophil Triton X-100-insoluble cytoskeletal fraction and PMA-activated membrane skeleton: a comparative study with P67phox and P47phox.	Tetradecanoylphorbol Acetate	88-91	neutrophil cytosolic factor 4	Homo sapiens	0-7
22382313-4	2012	KPS-A treatment reduced the stability of PMA-induced MMP-9 mRNA and inhibited the PMA-induced cytoplasmic translocation of HuR.	Tetradecanoylphorbol Acetate	82-85	ELAV like RNA binding protein 1	Homo sapiens	123-126
10614785-8	1999	Neutrophil activation by phorbol myristate acetate (PMA) induced p47phox translocation to the cytoskeleton but did not affect the distribution of p40phox or p67phox.	Tetradecanoylphorbol Acetate	25-50	pleckstrin	Homo sapiens	65-68
10614785-8	1999	Neutrophil activation by phorbol myristate acetate (PMA) induced p47phox translocation to the cytoskeleton but did not affect the distribution of p40phox or p67phox.	Tetradecanoylphorbol Acetate	52-55	pleckstrin	Homo sapiens	65-68
10569807-0	1999	12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mouse epidermis coexpressing transforming growth factor-alpha and v-fos: acceleration of autonomous papilloma formation and malignant conversion via c-Ha-ras activation.	Tetradecanoylphorbol Acetate	0-36	transforming growth factor alpha	Mus musculus	90-122
10569807-0	1999	12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mouse epidermis coexpressing transforming growth factor-alpha and v-fos: acceleration of autonomous papilloma formation and malignant conversion via c-Ha-ras activation.	Tetradecanoylphorbol Acetate	0-36	POC1 centriolar protein A	Mus musculus	210-214
10685001-7	2000	In the presence of L-NAME, PMA (1 nM) stimulation significantly increased superoxide anion generation following 3 h treatments with IL-3, TNF-alpha or IFN-gamma.	Tetradecanoylphorbol Acetate	27-30	interleukin 3	Homo sapiens	132-136
21445599-9	2012	Moreover, pretreatment with chelerythrine partially restored the ET-1-induced decrease in SERCA2 mRNA, whereas phorbol 12-myristate 13-acetate markedly reduced SERCA2 gene expression.	Tetradecanoylphorbol Acetate	111-142	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	160-166
10640296-1	2000	We previously reported that immunosuppressive cannabinoids inhibited interleukin (IL)-2 steady-state mRNA expression and secretion by phorbol-12-myristate-13-acetate plus ionomycin-activated mouse splenocytes and EL4 murine T-cells.	Tetradecanoylphorbol Acetate	134-165	interleukin 2	Mus musculus	69-87
10569807-4	1999	Previously, after 7 mo TPA promotion of HK1.TGFalpha mice that express moderate levels of TGFalpha elicited papillomas that remained regression-prone and benign for up to 2 yr.	Tetradecanoylphorbol Acetate	23-26	transforming growth factor alpha	Mus musculus	44-52
10569807-5	1999	In HK1.fos mice, 6 mo TPA elicited papillomas that required spontaneous c-Ha-ras activation and converted to malignancy after 14-16 mo.	Tetradecanoylphorbol Acetate	22-25	POC1 centriolar protein A	Mus musculus	72-76
10569807-9	1999	These data indicate that coexpression of fos and TGFalpha increased epidermal sensitivity to TPA promotion, which accelerated malignant conversion.	Tetradecanoylphorbol Acetate	93-96	transforming growth factor alpha	Mus musculus	49-57
10569809-0	1999	Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion.	Tetradecanoylphorbol Acetate	70-106	interleukin 1 alpha	Mus musculus	191-209
10535756-0	1999	Inhibition of 12-O-tetradecanoylphorbol-13-acetate induction of c-fos mRNA by the protein kinase A inhibitor N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide.	Tetradecanoylphorbol Acetate	14-50	FBJ osteosarcoma oncogene	Mus musculus	64-69
10535756-1	1999	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can induce expression of many immediate-early genes, such as c-fos and c-jun.	Tetradecanoylphorbol Acetate	19-55	FBJ osteosarcoma oncogene	Mus musculus	123-128
10535756-1	1999	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) can induce expression of many immediate-early genes, such as c-fos and c-jun.	Tetradecanoylphorbol Acetate	57-60	FBJ osteosarcoma oncogene	Mus musculus	123-128
10673366-4	2000	Treating K562 wild-type cells (K562-WT) with TPA stimulated an interaction between alpha5beta1 and OPN.	Tetradecanoylphorbol Acetate	45-48	secreted phosphoprotein 1	Homo sapiens	99-102
22685674-3	2012	We have found that TPA-induced differentiation of ML-1 cells was accompanied by the upregulation of TLR1, TLR2, TLR4, and CD14 expression at both the mRNA and protein levels.	Tetradecanoylphorbol Acetate	19-22	toll like receptor 4	Homo sapiens	112-116
10625683-9	2000	The involvement of protein tyrosine phosphatases (PTPases) in mediating the dephosphorylation of the focal adhesion PTKs was confirmed by the failure of PMA to dephosphorylate Pyk2 in cells pretreated with the PTPase inhibitor orthovanadate.	Tetradecanoylphorbol Acetate	153-156	protein tyrosine kinase 2 beta	Homo sapiens	176-180
12749772-8	2000	An L-selectin cytoplasmic tail deletion mutant (344del.15) expressed in L1.2 pre-B cells was down-modulated by PMA or sulfatides, but not Dreg 200.	Tetradecanoylphorbol Acetate	111-114	selectin L	Homo sapiens	3-13
10535756-2	1999	In this study, TPA increased c-fos mRNA, cellular cyclic AMP, and protein kinase A (PKA) activity in the first 30 min with similar inductive time courses.	Tetradecanoylphorbol Acetate	15-18	FBJ osteosarcoma oncogene	Mus musculus	29-34
10535756-3	1999	Treatment of NIH 3T3 cells with N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide (H-89), a PKA specific inhibitor, suppressed TPA induction of PKA activity and c-fos mRNA in a concentration-dependent manner, but did not inhibit serum-induced transcription.	Tetradecanoylphorbol Acetate	138-141	FBJ osteosarcoma oncogene	Mus musculus	172-177
10535756-6	1999	TPA stimulation of a c-fos promoter reporter construct was inhibited by overexpression of the dominant negative regulatory protein of PKA.	Tetradecanoylphorbol Acetate	0-3	FBJ osteosarcoma oncogene	Mus musculus	21-26
10535756-8	1999	These results suggest that H-89 will be very useful for investigating the molecular mechanism of TPA induction of c-fos.	Tetradecanoylphorbol Acetate	97-100	FBJ osteosarcoma oncogene	Mus musculus	114-119
10551813-6	1999	However, down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PKC inhibitor Ro-31-8220 did not block the activation of p70(S6k) by ROS, indicating that the activation of TPA-responsive PKC was not required for stimulation of p70(S6k) activity by H(2)O(2) in JB6 cells.	Tetradecanoylphorbol Acetate	66-69	ribosomal protein S6 kinase B1	Homo sapiens	213-216
10551813-6	1999	However, down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PKC inhibitor Ro-31-8220 did not block the activation of p70(S6k) by ROS, indicating that the activation of TPA-responsive PKC was not required for stimulation of p70(S6k) activity by H(2)O(2) in JB6 cells.	Tetradecanoylphorbol Acetate	66-69	ribosomal protein S6 kinase B1	Homo sapiens	319-322
10551813-6	1999	However, down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PKC inhibitor Ro-31-8220 did not block the activation of p70(S6k) by ROS, indicating that the activation of TPA-responsive PKC was not required for stimulation of p70(S6k) activity by H(2)O(2) in JB6 cells.	Tetradecanoylphorbol Acetate	134-137	ribosomal protein S6 kinase B1	Homo sapiens	213-216
21984036-4	2012	Here, we hypothesized that heparin has some influence on the expression of mucin 5AC (MUC5AC) induced by phorbol myristate acetate (PMA) in a bronchial epithelial cell line (HBE16), also we have investigated the potential mechanism involved in the process.	Tetradecanoylphorbol Acetate	105-130	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	75-84
10551813-6	1999	However, down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PKC inhibitor Ro-31-8220 did not block the activation of p70(S6k) by ROS, indicating that the activation of TPA-responsive PKC was not required for stimulation of p70(S6k) activity by H(2)O(2) in JB6 cells.	Tetradecanoylphorbol Acetate	134-137	ribosomal protein S6 kinase B1	Homo sapiens	319-322
21984036-4	2012	Here, we hypothesized that heparin has some influence on the expression of mucin 5AC (MUC5AC) induced by phorbol myristate acetate (PMA) in a bronchial epithelial cell line (HBE16), also we have investigated the potential mechanism involved in the process.	Tetradecanoylphorbol Acetate	105-130	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	86-92
10564110-1	1999	Treatment of HT-29 cells with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), induces MUC2 expression.	Tetradecanoylphorbol Acetate	30-61	protein kinase C epsilon	Homo sapiens	103-106
21984036-4	2012	Here, we hypothesized that heparin has some influence on the expression of mucin 5AC (MUC5AC) induced by phorbol myristate acetate (PMA) in a bronchial epithelial cell line (HBE16), also we have investigated the potential mechanism involved in the process.	Tetradecanoylphorbol Acetate	132-135	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	75-84
10564110-1	1999	Treatment of HT-29 cells with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), induces MUC2 expression.	Tetradecanoylphorbol Acetate	63-66	protein kinase C epsilon	Homo sapiens	103-106
11426586-6	2000	Troglitazone, a PPARgamma ligand, dramatically attenuated the PMA-induced osteopontin expression.	Tetradecanoylphorbol Acetate	62-65	secreted phosphoprotein 1	Homo sapiens	74-85
21984036-4	2012	Here, we hypothesized that heparin has some influence on the expression of mucin 5AC (MUC5AC) induced by phorbol myristate acetate (PMA) in a bronchial epithelial cell line (HBE16), also we have investigated the potential mechanism involved in the process.	Tetradecanoylphorbol Acetate	132-135	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	86-92
21989206-0	2011	Anti-inflammatory effect of transduced PEP-1-cyclophilin A in Raw264.7 cells and 12-O-tetradecanoylphorbol-13-acetate-induced mice.	Tetradecanoylphorbol Acetate	81-117	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	39-44
10567919-8	2000	In PC12K cells, which express only PLD2, treatment with nerve growth factor causes neurite outgrowth and increases expression of PLD2 mRNA and protein within 6-12 h. A corresponding increase is observed in membrane PLD activity and in phorbol-12-myristate-13-acetate (PMA)-stimulated PLD activity in intact cells.	Tetradecanoylphorbol Acetate	268-271	phospholipase D2	Rattus norvegicus	129-133
10697493-8	1999	Stable overexpression of p27Kip1 also enhanced TPA-induced differentiation of HL60 cells.	Tetradecanoylphorbol Acetate	47-50	cyclin dependent kinase inhibitor 1B	Homo sapiens	25-32
22048773-4	2011	We demonstrate that Pglyrp2(-/-) mice (but not Pglyrp3(-/-) and Pglyrp4(-/-) mice) are more sensitive to the development of 12-O-tetradecanoylphorbol 13-acetate-induced psoriasis-like inflammation, whereas Pglyrp1(-/-) mice are less sensitive.	Tetradecanoylphorbol Acetate	124-160	peptidoglycan recognition protein 2	Mus musculus	20-27
10634965-3	1999	METHODS: Basal, concanavalin A (Con A)-, and phorbol-12-myristate-13-acetate (PMA)-stimulated lymphocyte PC-1, aminopeptidase N (APN), and dipeptidylpeptidase IV (DPP IV) activities were determined in 16 patients with Type 2 diabetes before and after 3 months of metformin treatment.	Tetradecanoylphorbol Acetate	45-76	dipeptidyl peptidase 4	Homo sapiens	139-161
10634965-3	1999	METHODS: Basal, concanavalin A (Con A)-, and phorbol-12-myristate-13-acetate (PMA)-stimulated lymphocyte PC-1, aminopeptidase N (APN), and dipeptidylpeptidase IV (DPP IV) activities were determined in 16 patients with Type 2 diabetes before and after 3 months of metformin treatment.	Tetradecanoylphorbol Acetate	45-76	dipeptidyl peptidase 4	Homo sapiens	163-169
10543954-2	1999	A structural and kinetical approach to establish the function of the VR1 loop of t-PA in the context of the thrombin-VR1(tPA) variant is described.	Tetradecanoylphorbol Acetate	121-124	vault RNA 1-1	Homo sapiens	69-72
10543954-2	1999	A structural and kinetical approach to establish the function of the VR1 loop of t-PA in the context of the thrombin-VR1(tPA) variant is described.	Tetradecanoylphorbol Acetate	121-124	vault RNA 1-1	Homo sapiens	117-120
10698043-4	2000	We showed that the FLG 29.1 cells express proal (I) collagen mRNA, whose expression is modulated by phorbol esters (TPA).	Tetradecanoylphorbol Acetate	116-119	filaggrin	Homo sapiens	19-22
22048773-5	2011	The mechanism underlying this increased sensitivity of Pglyrp2(-/-) mice to 12-O-tetradecanoylphorbol 13-acetate-induced psoriasis-like inflammation is reduced recruitment of regulatory T cells to the skin and enhanced production and activation of Th17 cells in the skin in Pglyrp2(-/-) mice, which results in more severe inflammation and keratinocyte proliferation.	Tetradecanoylphorbol Acetate	76-112	peptidoglycan recognition protein 2	Mus musculus	55-62
10543954-4	1999	The contribution of a prominent charge substitution close to the active site was studied using charge neutralization variants thrombin-E39Q(c39) and thrombin-VR1(tPA)-R304Q(c39), resulting in only fourfold changes in the PAI-1 inhibition rate.	Tetradecanoylphorbol Acetate	162-165	vault RNA 1-1	Homo sapiens	158-161
10543954-5	1999	Surface plasmon resonance revealed that the affinity of initial reversible complex formation between PAI-1 and catalytically inactive Ser195--&gt;Ala variants of thrombin and thrombin-VR1(tPA) is only increased fivefold, i.e. KD is 652 and 128 nM for thrombin-S195A and thrombin-S195A-VR1(tPA), respectively.	Tetradecanoylphorbol Acetate	188-191	serpin family E member 1	Homo sapiens	101-106
11199328-10	2000	The production in culture of leptin by unstimulated PBMCs and those stimulated by phytohemagglutinin M or by phorbol myristate acetate isolated from cancer patients was very low; no differences were observed in comparison with leptin production by PBMCs from healthy individuals.	Tetradecanoylphorbol Acetate	109-134	leptin	Homo sapiens	29-35
22048773-5	2011	The mechanism underlying this increased sensitivity of Pglyrp2(-/-) mice to 12-O-tetradecanoylphorbol 13-acetate-induced psoriasis-like inflammation is reduced recruitment of regulatory T cells to the skin and enhanced production and activation of Th17 cells in the skin in Pglyrp2(-/-) mice, which results in more severe inflammation and keratinocyte proliferation.	Tetradecanoylphorbol Acetate	76-112	peptidoglycan recognition protein 2	Mus musculus	274-281
10567848-4	2000	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 20 ng/ ml) caused a marked increase in sodium-dependent L-alanine uptake after both 2 and 16 h of incubation, and the treatment with TPA (20 ng/ml) EGF (20 ng/ml) for 16 h resulted in significant acceleration of the TPA-stimulated increase in L-alanine uptake by LLC-PK1 cells.	Tetradecanoylphorbol Acetate	53-56	epidermal growth factor	Sus scrofa	206-209
10543954-5	1999	Surface plasmon resonance revealed that the affinity of initial reversible complex formation between PAI-1 and catalytically inactive Ser195--&gt;Ala variants of thrombin and thrombin-VR1(tPA) is only increased fivefold, i.e. KD is 652 and 128 nM for thrombin-S195A and thrombin-S195A-VR1(tPA), respectively.	Tetradecanoylphorbol Acetate	188-191	vault RNA 1-1	Homo sapiens	184-187
10512355-11	1999	Furthermore, wortmannin significantly inhibited both insulin and TPA effects on GLUT translocation and glucose uptake.	Tetradecanoylphorbol Acetate	65-68	glutaminase	Rattus norvegicus	80-84
21890901-5	2011	Reactivation of viral expression in YR2 cells by the phorbol 12-myristate 13-acetate (PMA) plus ionomycin combination was accompanied by a rapid but transient chromatin remodeling in the 5"-LTR, leading to an increased PU.1 and USF-1/USF-2 recruitment in vivo sustained by PMA/ionomycin-mediated USF phosphorylation.	Tetradecanoylphorbol Acetate	53-84	upstream transcription factor 1	Homo sapiens	228-233
10504298-7	1999	Compared to TPA-treated wild-type mice, the epidermis of TPA-treated K5-PKCalpha mice displayed increased expression of cyclooxygenase-2 (COX-2), the neutrophil chemotactic factor macrophage inflammatory protein-2 (MIP-2) mRNA and the proinflammatory cytokine TNFalpha mRNA but not IL-6 or IL-1alpha mRNA.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 alpha	Mus musculus	290-299
10585867-8	1999	One major protein of the first group, p42, had a rapid increase in synthesis that decreased by 8 h. Its synthesis was strongly enhanced by FK506, but reduced by rapamycin after ionomycin+PMA stimulation.	Tetradecanoylphorbol Acetate	187-190	cyclin dependent kinase 20	Homo sapiens	38-41
10528995-1	1999	The effects of topical applications of 2,3-dimethyl-6(2-dimethylaminoethyl)-6H-indolo-[2,3-b]quinoxaline (B-220), on 12-O-tetradecanoylphorbol-13-acetate (TPA) or benzoylperoxide (BPO) induced promotion of skin tumors and hyperplasia were studied in female SENCAR mice.	Tetradecanoylphorbol Acetate	155-158	protein tyrosine phosphatase, receptor type, C	Mus musculus	106-111
21890901-5	2011	Reactivation of viral expression in YR2 cells by the phorbol 12-myristate 13-acetate (PMA) plus ionomycin combination was accompanied by a rapid but transient chromatin remodeling in the 5"-LTR, leading to an increased PU.1 and USF-1/USF-2 recruitment in vivo sustained by PMA/ionomycin-mediated USF phosphorylation.	Tetradecanoylphorbol Acetate	86-89	upstream transcription factor 1	Homo sapiens	228-233
10528995-3	1999	Administration of B-220 1 h before TPA promotion resulted in a prolonged latency period of tumor appearance and a significantly reduced (up to 15% of positive controls) papilloma yield at 20 weeks.	Tetradecanoylphorbol Acetate	35-38	protein tyrosine phosphatase, receptor type, C	Mus musculus	18-23
21782040-8	2011	In HeLa cells, AL extract suppressed phorbol-12-myristate-13-acetate- or histamine-induced up-regulation of H1R mRNA.	Tetradecanoylphorbol Acetate	37-68	histamine receptor H1	Homo sapiens	108-111
10484455-4	1999	Significant enhancement of [(3)H]thymidine incorporation in HASM cultures was observed only by treatment with agents (epidermal growth factor, platelet-derived growth factor, thrombin, and phorbol 12-myristate 13-acetate) that promoted a strong and sustained activation of p42/p44 MAPK.	Tetradecanoylphorbol Acetate	189-220	cyclin dependent kinase 20	Homo sapiens	273-276
10625951-7	1999	Furthermore, we have investigated the role of PKC and its isozymes in the synergistic induction of PI-3 K by TPA and insulin and found that bisindolylmaleimide, a PKC inhibitor, inhibits TPA-induced PI-3 K. Overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the TPA- or TPA plus insulin-induced PI-3 K activity.	Tetradecanoylphorbol Acetate	109-112	protein kinase C epsilon	Homo sapiens	245-256
10590051-5	1999	Phorbol 12-myristate 13-acetate, which activated ERKs by a different mechanism, also suppressed the activation of JNKs and significantly retarded apoptosis of the cells caused by withdrawal of EPO.	Tetradecanoylphorbol Acetate	0-31	erythropoietin	Mus musculus	193-196
21839858-5	2011	Subsequently, over-expression of HMBOX1 significantly inhibited the expression and production of IFN-gamma in NK cells in response to the stimulation of tumor cell K562 or PMA/ionomycin.	Tetradecanoylphorbol Acetate	172-175	homeobox containing 1	Homo sapiens	33-39
10698257-3	1999	In this study, to determine the effects of TPA on Cx26 expression and its function in neuroblastoma, we transfected N2A mouse neuroblastoma cells (which are gap junction deficient) with the coding region of human Cx26 gene (which lacks TPA response elements) and examined the changes of expression and function of Cx26 following 10 nM TPA treatment.	Tetradecanoylphorbol Acetate	43-46	gap junction protein, beta 2	Mus musculus	50-54
10469621-4	1999	We also studied the localization of p53 protein after treatments with BP and TPA or thapsigargin.	Tetradecanoylphorbol Acetate	77-80	transformation related protein 53, pseudogene	Mus musculus	36-39
10469621-5	1999	Thapsigargin had a TPA-like effect on the acute induction of p53 protein related to benzo[a]pyrene-7, 8-diol-9,10-epoxide-DNA adducts in the skin of C57BL/6 mouse.	Tetradecanoylphorbol Acetate	19-22	transformation related protein 53, pseudogene	Mus musculus	61-64
10594650-8	1999	We also showed that inhibition of the tissue type plasminogen activator (tPA-stop/PAI-1) significantly interfered with the activity-induced increase in perforated synapses.	Tetradecanoylphorbol Acetate	73-76	plasminogen activator, tissue type	Rattus norvegicus	38-71
21734098-9	2011	In addition, AGE-BSA or suppression of NRP1 both reduced the phosphorylation of focal adhesion kinase (FAK) and Erk1/2 in PMA-stimulated differentiated podocytes.	Tetradecanoylphorbol Acetate	122-125	PTK2 protein tyrosine kinase 2	Mus musculus	80-101
10528235-2	1999	The proinflammatory phorbol ester, phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), inhibits basal and cyclic adenosine monophosphate (cAMP)-stimulated NKCC1 activity in T84 intestinal epithelial cells and decreases the steady state levels of NKCC1 mRNA in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	35-66	solute carrier family 12 member 2	Homo sapiens	182-187
10528235-2	1999	The proinflammatory phorbol ester, phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), inhibits basal and cyclic adenosine monophosphate (cAMP)-stimulated NKCC1 activity in T84 intestinal epithelial cells and decreases the steady state levels of NKCC1 mRNA in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	35-66	solute carrier family 12 member 2	Homo sapiens	273-278
10479400-8	1999	PD98059 also inhibited induction of IL-2 by phorbol 12-myristate 13-acetate (PMA), and AP1-linked reporter gene expression in response to PMA but not IL-1.	Tetradecanoylphorbol Acetate	44-75	interleukin 2	Mus musculus	36-40
10454570-0	1999	Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	202-231	ETS proto-oncogene 2, transcription factor	Homo sapiens	83-88
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	260-263	interleukin 1 alpha	Homo sapiens	237-241
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	260-263	interleukin 1 alpha	Homo sapiens	401-405
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	381-384	interleukin 1 alpha	Homo sapiens	237-241
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	381-384	interleukin 1 alpha	Homo sapiens	401-405
10528235-2	1999	The proinflammatory phorbol ester, phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), inhibits basal and cyclic adenosine monophosphate (cAMP)-stimulated NKCC1 activity in T84 intestinal epithelial cells and decreases the steady state levels of NKCC1 mRNA in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	68-71	solute carrier family 12 member 2	Homo sapiens	182-187
10528235-2	1999	The proinflammatory phorbol ester, phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), inhibits basal and cyclic adenosine monophosphate (cAMP)-stimulated NKCC1 activity in T84 intestinal epithelial cells and decreases the steady state levels of NKCC1 mRNA in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	68-71	solute carrier family 12 member 2	Homo sapiens	273-278
21734098-9	2011	In addition, AGE-BSA or suppression of NRP1 both reduced the phosphorylation of focal adhesion kinase (FAK) and Erk1/2 in PMA-stimulated differentiated podocytes.	Tetradecanoylphorbol Acetate	122-125	PTK2 protein tyrosine kinase 2	Mus musculus	103-106
21689256-3	2011	Phorbol 12-myristate 13-acetate (PMA) is known to enhance the percentage of fusion-competent vesicles and this is mediated by protein kinase C (PKC)-independent Munc13-1 activation and PKC-dependent dissociation of Munc18-1 from syntaxin 1a.	Tetradecanoylphorbol Acetate	0-31	syntaxin 1A	Homo sapiens	229-240
10569809-10	1999	In other studies, silymarin also showed dose-dependent inhibition of TPA-caused induction of epidermal interleukin 1alpha (IL-1alpha) protein (39-72% inhibition, P &lt; 0.005 or 0.001) and mRNA expression.	Tetradecanoylphorbol Acetate	69-72	interleukin 1 alpha	Mus musculus	103-121
10569809-10	1999	In other studies, silymarin also showed dose-dependent inhibition of TPA-caused induction of epidermal interleukin 1alpha (IL-1alpha) protein (39-72% inhibition, P &lt; 0.005 or 0.001) and mRNA expression.	Tetradecanoylphorbol Acetate	69-72	interleukin 1 alpha	Mus musculus	123-132
10551813-6	1999	However, down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PKC inhibitor Ro-31-8220 did not block the activation of p70(S6k) by ROS, indicating that the activation of TPA-responsive PKC was not required for stimulation of p70(S6k) activity by H(2)O(2) in JB6 cells.	Tetradecanoylphorbol Acetate	134-137	ribosomal protein S6 kinase B1	Homo sapiens	213-216
10551813-6	1999	However, down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PKC inhibitor Ro-31-8220 did not block the activation of p70(S6k) by ROS, indicating that the activation of TPA-responsive PKC was not required for stimulation of p70(S6k) activity by H(2)O(2) in JB6 cells.	Tetradecanoylphorbol Acetate	134-137	ribosomal protein S6 kinase B1	Homo sapiens	319-322
10455142-2	1999	Pretreatment with hyperosmotic stress also prevented the activation of S6K by both 12-O-tetradecanoylphorbol-13-acetate and anisomycin.	Tetradecanoylphorbol Acetate	83-119	ribosomal protein S6 kinase B1	Homo sapiens	71-74
10400704-9	1999	The protein-tyrosine kinase inhibitor genistein and the phosphatidylinositol 3-kinase inhibitor wortmannin inhibited the phosphorylation of p47(phox) induced by GM-CSF and by fMLP but not that induced by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	204-235	pleckstrin	Homo sapiens	140-143
10400704-9	1999	The protein-tyrosine kinase inhibitor genistein and the phosphatidylinositol 3-kinase inhibitor wortmannin inhibited the phosphorylation of p47(phox) induced by GM-CSF and by fMLP but not that induced by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	204-235	pleckstrin	Homo sapiens	144-148
10397677-6	1999	The inhibition of PKC by chelerythrine or its downregulation by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis and blocked the phosphorylation of MAPK and c-myc expression in response to bFGF.	Tetradecanoylphorbol Acetate	64-95	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	183-188
10397677-6	1999	The inhibition of PKC by chelerythrine or its downregulation by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis and blocked the phosphorylation of MAPK and c-myc expression in response to bFGF.	Tetradecanoylphorbol Acetate	97-100	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	183-188
21689256-3	2011	Phorbol 12-myristate 13-acetate (PMA) is known to enhance the percentage of fusion-competent vesicles and this is mediated by protein kinase C (PKC)-independent Munc13-1 activation and PKC-dependent dissociation of Munc18-1 from syntaxin 1a.	Tetradecanoylphorbol Acetate	33-36	syntaxin 1A	Homo sapiens	229-240
10674883-6	1999	Here, we demonstrate the effects of steroids/thyroids/retinoids and of activators of protein kinase A (forskolin, Forsk) and C (12-O-tetradecanoylphorbol-13-acetate, TPA), on growth and expression of c-erbB and RARs in MCF-7 breast cancer cells, which contain high levels of RAR-alpha and -gamma, and which express significant amounts of c-erbB-2 and -3.	Tetradecanoylphorbol Acetate	128-164	retinoic acid receptor alpha	Homo sapiens	275-284
21689256-4	2011	Our results show that the effects of PMA varied in cells overexpressing Rab3A or mutants of Rab3A and in cells with Rab3A knockdown.	Tetradecanoylphorbol Acetate	37-40	RAB3A, member RAS oncogene family	Homo sapiens	72-77
10674883-10	1999	Northern analysis demonstrated that RAR-alpha was down-regulated by dexamethasone, ICI, and TPA, whereas vitamin D3 and E2 up-regulated RAR-alpha.	Tetradecanoylphorbol Acetate	92-95	retinoic acid receptor alpha	Homo sapiens	36-45
14634280-2	1999	Furthermore, the NF-kappa B/Rel inducer, phorbol-12-myristate-13-acetate (PMA), has been reported to suppress the CD95-induced apoptosis of human T lymphocytes.	Tetradecanoylphorbol Acetate	41-72	Fas cell surface death receptor	Homo sapiens	114-118
21689256-4	2011	Our results show that the effects of PMA varied in cells overexpressing Rab3A or mutants of Rab3A and in cells with Rab3A knockdown.	Tetradecanoylphorbol Acetate	37-40	RAB3A, member RAS oncogene family	Homo sapiens	92-97
14634280-2	1999	Furthermore, the NF-kappa B/Rel inducer, phorbol-12-myristate-13-acetate (PMA), has been reported to suppress the CD95-induced apoptosis of human T lymphocytes.	Tetradecanoylphorbol Acetate	74-77	Fas cell surface death receptor	Homo sapiens	114-118
21689256-4	2011	Our results show that the effects of PMA varied in cells overexpressing Rab3A or mutants of Rab3A and in cells with Rab3A knockdown.	Tetradecanoylphorbol Acetate	37-40	RAB3A, member RAS oncogene family	Homo sapiens	92-97
10339499-2	1999	Constitutive expression of v-Myc blocks phorbol ester (TPA)-induced differentiation of human U-937 monoblasts.	Tetradecanoylphorbol Acetate	55-58	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	29-32
10556814-6	1999	Activation of T cells with phorbol 12-myristate 13-acetate plus ionomycin or anti-CD3 plus anti-CD28 monoclonal antibodies induces a suppression of CTLA-4delTM mRNA expression associated with a preferential expression of the membrane CTLA-4 mRNA, showing that CTLA-4delTM mRNA expression is restricted to nonactivated T cells.	Tetradecanoylphorbol Acetate	27-58	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	148-154
10339499-3	1999	However, costimulation with interferon-gamma (IFN-gamma) and TPA restores terminal differentiation and G1 cell-cycle arrest despite continuous expression of v-Myc.	Tetradecanoylphorbol Acetate	61-64	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	159-162
21734014-4	2011	CXCR3 deletion did not affect tumor development in the MCA model; however, CXCR3 was important in the DMBA/TPA model where gene deletion reduced the incidence of skin tumors.	Tetradecanoylphorbol Acetate	107-110	chemokine (C-X-C motif) receptor 3	Mus musculus	75-80
10339499-4	1999	The mechanism by which TPA + IFN-gamma counteract v-Myc activity has not been unravelled.	Tetradecanoylphorbol Acetate	23-26	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	52-55
10339499-5	1999	Our results show that TPA + IFN-gamma treatment led to an inhibition of v-Myc- and c-Myc-dependent transcription, and a specific reduction of v-Myc:Max complexes and associated DNA-binding activity, whereas the steady state level of the v-Myc protein was only marginally affected.	Tetradecanoylphorbol Acetate	22-25	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	74-77
10339499-5	1999	Our results show that TPA + IFN-gamma treatment led to an inhibition of v-Myc- and c-Myc-dependent transcription, and a specific reduction of v-Myc:Max complexes and associated DNA-binding activity, whereas the steady state level of the v-Myc protein was only marginally affected.	Tetradecanoylphorbol Acetate	22-25	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	83-88
10339499-5	1999	Our results show that TPA + IFN-gamma treatment led to an inhibition of v-Myc- and c-Myc-dependent transcription, and a specific reduction of v-Myc:Max complexes and associated DNA-binding activity, whereas the steady state level of the v-Myc protein was only marginally affected.	Tetradecanoylphorbol Acetate	22-25	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	85-88
21734014-5	2011	This decreased incidence of skin tumors did not reflect differences in epidermal development but rather was associated with reduced epidermal thickness and proliferation in CXCR3(-/-) mice, implicating the CXCR3 pathway in DMBA/TPA-induced epidermal inflammation and proliferation.	Tetradecanoylphorbol Acetate	228-231	chemokine (C-X-C motif) receptor 3	Mus musculus	206-211
10339499-5	1999	Our results show that TPA + IFN-gamma treatment led to an inhibition of v-Myc- and c-Myc-dependent transcription, and a specific reduction of v-Myc:Max complexes and associated DNA-binding activity, whereas the steady state level of the v-Myc protein was only marginally affected.	Tetradecanoylphorbol Acetate	22-25	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	85-88
10339499-8	1999	Phosphatase treatment of Myc:Max complexes lead to their dissociation, thus mimicking the effect of TPA + IFN-gamma.	Tetradecanoylphorbol Acetate	100-103	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	25-28
21558327-4	2011	Following TPA treatment, we observed a 3.5-fold increase in GlcCer levels that was caused by enhanced activity of ceramide glucosyltransferase (GlcT-1), which catalyses ceramide glycosylation.	Tetradecanoylphorbol Acetate	10-13	UDP-glucose ceramide glucosyltransferase	Homo sapiens	114-142
10328761-12	1999	To demonstrate the utility of this assay as a screen for thrombolytic agents, a 14-amino-acid PAI-1-inhibitory peptide relieved the PAI-1 effect on tPA in a dose-dependent fashion.	Tetradecanoylphorbol Acetate	148-151	serpin family E member 1	Homo sapiens	94-99
10328761-12	1999	To demonstrate the utility of this assay as a screen for thrombolytic agents, a 14-amino-acid PAI-1-inhibitory peptide relieved the PAI-1 effect on tPA in a dose-dependent fashion.	Tetradecanoylphorbol Acetate	148-151	serpin family E member 1	Homo sapiens	132-137
10521422-2	1999	Here we show that in mouse Ltk(-) fibroblasts, calcium ionophore acts in synergy with either cAMP or PMA to strongly induce the endogenous c-fos gene.	Tetradecanoylphorbol Acetate	101-104	FBJ osteosarcoma oncogene	Mus musculus	139-144
10529397-2	1999	Insulin, epidermal growth factor, interleukin 6, cAMP, phorbol 12-myristate 13-acetate, tumor necrosis factor alpha, vanadate, and okadaic acid were found to suppress the induction of CYP2B1/2B2 at mRNA and protein levels in hepatocytes.	Tetradecanoylphorbol Acetate	55-86	cytochrome P450, family 2, subfamily b, polypeptide 2	Rattus norvegicus	184-194
21558327-4	2011	Following TPA treatment, we observed a 3.5-fold increase in GlcCer levels that was caused by enhanced activity of ceramide glucosyltransferase (GlcT-1), which catalyses ceramide glycosylation.	Tetradecanoylphorbol Acetate	10-13	UDP-glucose ceramide glucosyltransferase	Homo sapiens	144-150
10344756-3	1999	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced immediate early genes, such as c-Jun, c-Fos, and Egr-1 in activated Ki-ras-disrupted clones, whereas c-Jun induction was rare in HCT116.	Tetradecanoylphorbol Acetate	0-36	early growth response 1	Homo sapiens	100-105
21558327-5	2011	Furthermore, in TPA-treated cell GlcT-1 amounts were increased at both the mRNA and protein levels.	Tetradecanoylphorbol Acetate	16-19	UDP-glucose ceramide glucosyltransferase	Homo sapiens	33-39
10490652-9	1999	Stimulation of S100B-REF cells with the PKC activator phorbol ester phorbol myristate acetate (PMA) promoted specific nuclear translocation of the wild-type p53Val135 species in cells positioned in early G(1) phase of the cell cycle.	Tetradecanoylphorbol Acetate	68-93	S100 protein, beta polypeptide, neural	Mus musculus	15-20
21570947-5	2011	Mutating the putative PKC phosphorylation site Thr(286) of hSMVT led to a significant decrease in the PMA-induced inhibition in biotin uptake.	Tetradecanoylphorbol Acetate	102-105	solute carrier family 5 member 6	Homo sapiens	59-64
10490652-9	1999	Stimulation of S100B-REF cells with the PKC activator phorbol ester phorbol myristate acetate (PMA) promoted specific nuclear translocation of the wild-type p53Val135 species in cells positioned in early G(1) phase of the cell cycle.	Tetradecanoylphorbol Acetate	68-93	transformation related protein 53, pseudogene	Mus musculus	157-160
10490652-9	1999	Stimulation of S100B-REF cells with the PKC activator phorbol ester phorbol myristate acetate (PMA) promoted specific nuclear translocation of the wild-type p53Val135 species in cells positioned in early G(1) phase of the cell cycle.	Tetradecanoylphorbol Acetate	95-98	S100 protein, beta polypeptide, neural	Mus musculus	15-20
10490652-9	1999	Stimulation of S100B-REF cells with the PKC activator phorbol ester phorbol myristate acetate (PMA) promoted specific nuclear translocation of the wild-type p53Val135 species in cells positioned in early G(1) phase of the cell cycle.	Tetradecanoylphorbol Acetate	95-98	transformation related protein 53, pseudogene	Mus musculus	157-160
10490652-10	1999	PMA also substituted for ionomycin in the mediating of p53-dependent G(1) arrest at the nonpermissive temperature (37.5 degrees C).	Tetradecanoylphorbol Acetate	0-3	transformation related protein 53, pseudogene	Mus musculus	55-58
10229812-6	1999	Furthermore, PMA-induced activation of LFA-1 on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but independent of mitogen-activated protein kinase activation, whereas cytokine-induced activation was independent of protein kinase C and mitogen-activated protein kinase activation but required phosphatidylinositol-3 kinase activation.	Tetradecanoylphorbol Acetate	13-16	integrin alpha L	Mus musculus	39-44
10229812-6	1999	Furthermore, PMA-induced activation of LFA-1 on DA-ER cells overexpressing wild-type SHIP was dependent on protein kinase C but independent of mitogen-activated protein kinase activation, whereas cytokine-induced activation was independent of protein kinase C and mitogen-activated protein kinase activation but required phosphatidylinositol-3 kinase activation.	Tetradecanoylphorbol Acetate	13-16	inositol polyphosphate-5-phosphatase D	Mus musculus	85-89
10329260-5	1999	Phorbol myristate acetate, known to induce protease activity in other endothelial cell populations, stimulated MMP1, MMP9, and TIMP1 secretion in both NDEC and PEDEC.	Tetradecanoylphorbol Acetate	0-25	matrix metallopeptidase 1	Homo sapiens	111-115
10547001-0	1999	Evidence from studies with N-ethyl-maleimide and 12-O-tetradecanoylphorbol-13-acetate that AP-1 and CREB are involved in the glucocorticoid activation of TRH gene expression in hypothalamic cultures.	Tetradecanoylphorbol Acetate	49-85	cAMP responsive element binding protein 1	Rattus norvegicus	100-104
21631112-5	2011	Similarly, in the murine ear edema model, 12-O-tetradecanoylphorbol-13-acetate-induced inflammation was inhibited by mogrosides by down-regulating COX-2 and IL-6 and up-regulating PARP1, BCL2l1, TRP53, MAPK9, and PPARdelta gene expression.	Tetradecanoylphorbol Acetate	42-78	transformation related protein 53	Mus musculus	195-200
10212212-7	1999	Metabolic 32P labeling of hARNT in cells treated with carrier solvent or 81 nM PMA demonstrates that PMA does not increase the overall phosphorylation level of hARNT.	Tetradecanoylphorbol Acetate	79-82	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	26-31
21411725-7	2011	In recombinant baby hamster kidney cells, endogenously expressing PKCepsilon but no VIP receptor, wild-type, and F508del-CFTR sensitivity to cpt-cAMP stimulation was increased by PMA treatment.	Tetradecanoylphorbol Acetate	179-182	protein kinase C epsilon	Homo sapiens	66-76
10205165-4	1999	Treatment with phorbol 12-myristate 13-acetate (PMA) allows alphavbeta3 to locate to the focal adhesion contacts and the cells to spread on vitronectin in the presence of CKI peptides.	Tetradecanoylphorbol Acetate	15-46	choline kinase alpha	Homo sapiens	171-174
10205165-4	1999	Treatment with phorbol 12-myristate 13-acetate (PMA) allows alphavbeta3 to locate to the focal adhesion contacts and the cells to spread on vitronectin in the presence of CKI peptides.	Tetradecanoylphorbol Acetate	48-51	choline kinase alpha	Homo sapiens	171-174
10615432-11	1999	Furthermore, in both cell types, the secretion of TIMP-2 was enhanced by tPA and PDGF, but not by uPA or bFGF.	Tetradecanoylphorbol Acetate	73-76	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	50-56
10412037-7	1999	It is suggested that the inhibition of intercellular communication, in the presence of TPA, depends on the pH(i)-shift itself rather than on the absolute value of pH(i).	Tetradecanoylphorbol Acetate	87-90	glucose-6-phosphate isomerase	Rattus norvegicus	107-112
10209302-6	1999	10 nM TNF-alpha pretreatment also suppressed 10 nM insulin- and 1 microM TPA-induced increases in membrane-associated PKCbeta and PKCzeta.	Tetradecanoylphorbol Acetate	73-76	insulin 1	Rattus norvegicus	51-65
21381080-6	2011	The upregulation of Cldn18 by TPA in human pancreatic cancer cell lines was prevented by inhibitors of PKCdelta, PKCepsilon, and PKCalpha, whereas the upregulation of Cldn18 by TPA in hTERT-HPDE cells was prevented by inhibitors of PKCdelta, PKCtheta, and PKCalpha.	Tetradecanoylphorbol Acetate	30-33	protein kinase C epsilon	Homo sapiens	113-123
10412037-10	1999	These results indicate that shift of pH(i) and the increase of intracellular calcium are involved in repression of intercellular communication by TPA.	Tetradecanoylphorbol Acetate	146-149	glucose-6-phosphate isomerase	Rattus norvegicus	37-42
10536988-4	1999	TPA-treatment also causes secretion of urokinase-type plasminogen activator (uPA) and expression of its receptor (uPAR), which activates plasminogen to plasmin and may digest extracellular domains of desmosomes and hemidesmosomes.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase receptor	Homo sapiens	114-118
21367956-8	2011	Interestingly, when JB6 cells were treated with carbon monoxide-releasing molecule that mimics the HO-1 activity, the TPA-induced ROS production was markedly reduced.	Tetradecanoylphorbol Acetate	118-121	heme oxygenase 1	Homo sapiens	99-103
10662597-1	1999	We studied the regulation of the human Galbeta1, 3GalNAc/Galbeta1,4GlcNAc alpha2,3-sialyltransferase (hST3Gal IV) gene during HL-60 cell differentiation induced by dimethyl sulfoxide (DMSO), all trans-retinoic acid (ATRA), and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	227-252	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	102-113
10662597-1	1999	We studied the regulation of the human Galbeta1, 3GalNAc/Galbeta1,4GlcNAc alpha2,3-sialyltransferase (hST3Gal IV) gene during HL-60 cell differentiation induced by dimethyl sulfoxide (DMSO), all trans-retinoic acid (ATRA), and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	254-257	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	102-113
10203357-10	1999	The suppression of MKP-1 was PKC-dependent since incubation of HG cells with phorbol 12-myristate 13-acetate for 24 h abolished it.	Tetradecanoylphorbol Acetate	77-108	dual specificity phosphatase 1	Rattus norvegicus	19-24
10201899-4	1999	However, p38 MAPK is activated strongly and synergistically by either CD3/CD28 coligation or PMA/Ca2+ ionophore stimulation, which mimics TCR-CD3/CD28-mediated signaling.	Tetradecanoylphorbol Acetate	93-96	CD28 antigen	Mus musculus	146-150
21901168-5	2011	PMA induces the dissociation, which leads to relocation of MEK1 to lipid rafts and WOX1 to the mitochondria for causing apoptosis.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 1	Homo sapiens	59-63
10214873-9	1999	However, the levels of MIP-1alpha were increased 10- to 100-fold by treatment with phorbol ester TPA.	Tetradecanoylphorbol Acetate	97-100	C-C motif chemokine ligand 3	Homo sapiens	23-33
10079079-8	1999	The mRNA of NF90 was decreased by TPA treatment in THP-1 cells but not in HeLa cells.	Tetradecanoylphorbol Acetate	34-37	interleukin enhancer binding factor 3	Homo sapiens	12-16
10092052-7	1999	IL-1alpha production was not modulated by FA or DEP even in the presence of PMA.	Tetradecanoylphorbol Acetate	76-79	interleukin 1 alpha	Homo sapiens	0-9
10449779-6	1999	TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3.	Tetradecanoylphorbol Acetate	25-61	matrix metallopeptidase 11	Mus musculus	259-272
10449779-6	1999	TAM67 expression blocked 12-O-tetradecanoylphorbol 13-acetate (TPA, phorbol 12-tetradecanoate 13-acetate) induction of the AP-1-regulated luciferase in AP-1 luciferase/TAM67 mice, but did not inhibit induction of candidate AP-1 target genes, collagenase-1 or stromelysin-3.	Tetradecanoylphorbol Acetate	63-66	matrix metallopeptidase 11	Mus musculus	259-272
10446065-4	1999	When treated with IL-6, macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells showed significantly reduced uptake and/or binding of the MSR ligand, acetylated LDL.	Tetradecanoylphorbol Acetate	74-105	progestin and adipoQ receptor family member 7	Homo sapiens	207-210
10446065-4	1999	When treated with IL-6, macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells showed significantly reduced uptake and/or binding of the MSR ligand, acetylated LDL.	Tetradecanoylphorbol Acetate	107-110	progestin and adipoQ receptor family member 7	Homo sapiens	207-210
21901168-6	2011	U0126 inhibits PMA-induced dissociation of WOX1/MEK1 complex and supports survival of Jurkat cells.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase kinase 1	Homo sapiens	48-52
21225617-3	2011	METHODS AND RESULTS: 5-Demethylnobiletin significantly attenuated phorbol 12-myristate 13-acetate-induced gene expression and activity of scavenger receptors, CD36, scavenger receptor-A and lectin-like oxidized LDL receptor-1.	Tetradecanoylphorbol Acetate	66-97	low density lipoprotein receptor	Homo sapiens	211-223
10482923-11	1999	Go 6976 (an inhibitor of conventional PKCalpha, beta and gamma) and LY 379196 (a selective PKCbeta inhibitor) also dose-dependently inhibited the PMA-mediated desensitization.	Tetradecanoylphorbol Acetate	146-149	protein kinase C beta	Bos taurus	91-98
10482923-13	1999	Transfection of PKCbeta-specific antisense oligonucleotide reduced PKCbetaI protein level and inhibited PMA-mediated PI reduction.	Tetradecanoylphorbol Acetate	104-107	protein kinase C beta	Bos taurus	16-23
10543370-6	1999	Although phorbol 12-myristate 13-acetate strongly induced p21 and stabilised p53 in the resting transfected Jurkat cells, neither apoptosis nor cell arrest was observed.	Tetradecanoylphorbol Acetate	9-40	H3 histone pseudogene 16	Homo sapiens	58-61
10084602-8	1999	Epidermal growth factor treatment led to an increase in CD97 immunostaining (up to 90%), whereas phorbol 12-myristate 13-acetate slightly decreased the immunoreactivity of CD97 (from 50% to 30%).	Tetradecanoylphorbol Acetate	97-128	adhesion G protein-coupled receptor E5	Homo sapiens	172-176
10102471-11	1999	PD 098059 and U0126, both highly specific MEK inhibitors, efficiently prevented PMA-induced PAI-1 synthesis (mRNA and protein levels) and cell adhesion whereas SB203580, a specific inhibitor of stress-activated MAPK p38, did not.	Tetradecanoylphorbol Acetate	80-83	serpin family E member 1	Homo sapiens	92-97
10102471-13	1999	In conclusion, we propose that the pathway PKCbeta-MEK-MAPK p42 is a potential linear route for PAI-1 synthesis leading to morphological changes and adherence linked to PMA-induced differentiation in HL-60 cells.	Tetradecanoylphorbol Acetate	169-172	cyclin dependent kinase 20	Homo sapiens	60-63
10102471-13	1999	In conclusion, we propose that the pathway PKCbeta-MEK-MAPK p42 is a potential linear route for PAI-1 synthesis leading to morphological changes and adherence linked to PMA-induced differentiation in HL-60 cells.	Tetradecanoylphorbol Acetate	169-172	serpin family E member 1	Homo sapiens	96-101
9933022-9	1999	12-O-Tetradecanoylphorbol 13-acetate (TPA), a known AP-1 agonist, induced ERCC-1 mRNA to the same extent as cisplatin, but did not synergize with cisplatin in this regard.	Tetradecanoylphorbol Acetate	0-36	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	74-80
9933022-9	1999	12-O-Tetradecanoylphorbol 13-acetate (TPA), a known AP-1 agonist, induced ERCC-1 mRNA to the same extent as cisplatin, but did not synergize with cisplatin in this regard.	Tetradecanoylphorbol Acetate	38-41	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	74-80
21297032-11	2011	These results suggest that the MEK/ERK1/2 pathway is necessary but not sufficient to regulate the PMA-dependent activation of Nox5.	Tetradecanoylphorbol Acetate	98-101	NADPH oxidase 5	Homo sapiens	126-130
9933619-0	1999	TGF-beta3, but not TGF-beta1, protects keratinocytes against 12-O-tetradecanoylphorbol-13-acetate-induced cell death in vitro and in vivo.	Tetradecanoylphorbol Acetate	61-97	transforming growth factor, beta 3	Mus musculus	0-9
9933619-7	1999	In marked contrast, TPA treatment of TGF-beta3 knockout grafts induced widespread areas of keratinocyte cell death.	Tetradecanoylphorbol Acetate	20-23	transforming growth factor, beta 3	Mus musculus	37-46
21216846-4	2011	p-HPEA-EDA inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced phosphorylation of extracellular signal-regulated kinases 1/2 and p90RSK in JB6 Cl41 cells, resulting in the inhibition of cell proliferation, activator protein-1 transactivation and cell transformation promoted by TPA.	Tetradecanoylphorbol Acetate	59-62	ribosomal protein S6 kinase A1	Homo sapiens	138-144
9933619-8	1999	Analysis of cultured keratinocytes treated with purified TGF-beta isoforms revealed that TGF-beta3 plays a direct and specific function in protecting keratinocytes against TPA-induced cell death.	Tetradecanoylphorbol Acetate	172-175	transforming growth factor, beta 3	Mus musculus	89-98
9933619-9	1999	The protective function of TGF-beta3 on TPA-induced cell death was not because of general suppression of the signaling pathways triggered by this agent, as ERK1/2 activation occurred to a similar if not greater extent in TGF-beta3-treated versus control keratinocytes.	Tetradecanoylphorbol Acetate	40-43	transforming growth factor, beta 3	Mus musculus	27-36
9933619-10	1999	Instead, TGF-beta3 treatment led to a significant reduction in TPA-induced c-Jun N-terminal kinase activity, which was associated and possibly explained by specific counteracting effects of TGF-beta3 on TPA-induced disruption of keratinocyte focal adhesions.	Tetradecanoylphorbol Acetate	63-66	transforming growth factor, beta 3	Mus musculus	9-18
21282359-3	2011	We showed that the expression of mda-7/IL-24 and IL-24 delE5, an mda-7/IL-24 splice variant, was induced in U937 and HL60 cells during 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated monocytic differentiation.	Tetradecanoylphorbol Acetate	135-171	interleukin 24	Homo sapiens	33-38
9933619-10	1999	Instead, TGF-beta3 treatment led to a significant reduction in TPA-induced c-Jun N-terminal kinase activity, which was associated and possibly explained by specific counteracting effects of TGF-beta3 on TPA-induced disruption of keratinocyte focal adhesions.	Tetradecanoylphorbol Acetate	63-66	transforming growth factor, beta 3	Mus musculus	190-199
9933619-10	1999	Instead, TGF-beta3 treatment led to a significant reduction in TPA-induced c-Jun N-terminal kinase activity, which was associated and possibly explained by specific counteracting effects of TGF-beta3 on TPA-induced disruption of keratinocyte focal adhesions.	Tetradecanoylphorbol Acetate	203-206	transforming growth factor, beta 3	Mus musculus	9-18
9933619-10	1999	Instead, TGF-beta3 treatment led to a significant reduction in TPA-induced c-Jun N-terminal kinase activity, which was associated and possibly explained by specific counteracting effects of TGF-beta3 on TPA-induced disruption of keratinocyte focal adhesions.	Tetradecanoylphorbol Acetate	203-206	transforming growth factor, beta 3	Mus musculus	190-199
9920899-8	1999	Finally, MDC9 is shown to become phosphorylated when cells are treated with the phorbol ester phorbol 12-myristate 13-acetate, a known inducer of protein ectodomain shedding.	Tetradecanoylphorbol Acetate	94-125	ADAM metallopeptidase domain 9	Homo sapiens	9-13
10037143-2	1999	We found that phorbol 12-myristate 13-acetate (PMA) induced upregulation of p21, not only in MCF-7 cells arrested in the G1 phase as previously shown, but also in cells delayed in the G2 phase.	Tetradecanoylphorbol Acetate	14-45	H3 histone pseudogene 16	Homo sapiens	76-79
10037143-2	1999	We found that phorbol 12-myristate 13-acetate (PMA) induced upregulation of p21, not only in MCF-7 cells arrested in the G1 phase as previously shown, but also in cells delayed in the G2 phase.	Tetradecanoylphorbol Acetate	47-50	H3 histone pseudogene 16	Homo sapiens	76-79
10027304-11	1999	Overexpression of c-myc was inhibited by TPA and p21waf1/cip1 mRNA increased.	Tetradecanoylphorbol Acetate	41-44	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
9925748-6	1999	12-O-Tetradecanoylphorbol 13-acetate (TPA), a protein kinase C (PKC)-activating phorbol ester, induced an accumulation of HSP27 (EC50, 20 nmol/L) and alphaB-crystallin (EC50, 2 nmol/L).	Tetradecanoylphorbol Acetate	0-36	heat shock protein family B (small) member 1	Homo sapiens	122-127
9925748-6	1999	12-O-Tetradecanoylphorbol 13-acetate (TPA), a protein kinase C (PKC)-activating phorbol ester, induced an accumulation of HSP27 (EC50, 20 nmol/L) and alphaB-crystallin (EC50, 2 nmol/L).	Tetradecanoylphorbol Acetate	38-41	heat shock protein family B (small) member 1	Homo sapiens	122-127
9927621-9	1999	TPA caused only a small activation of JNK relative to that caused by NE, which was not affected by TG.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 8	Rattus norvegicus	38-41
9927621-10	1999	The potent PKC inhibitor bisindolylmaleimide I dose dependently inhibited ERK and JNK activation by TPA, but not NE.	Tetradecanoylphorbol Acetate	100-103	mitogen-activated protein kinase 8	Rattus norvegicus	82-85
9891005-6	1999	Furthermore, repression of GnRH gene transcription by 12-O-tetradecanoylphorbol-13-acetate, which utilizes sequences that overlap with the nGRE, is reversed by this distal nGRE mutation leading to activation of GnRH gene transcription.	Tetradecanoylphorbol Acetate	54-90	gonadotropin releasing hormone 1	Mus musculus	27-31
9891005-6	1999	Furthermore, repression of GnRH gene transcription by 12-O-tetradecanoylphorbol-13-acetate, which utilizes sequences that overlap with the nGRE, is reversed by this distal nGRE mutation leading to activation of GnRH gene transcription.	Tetradecanoylphorbol Acetate	54-90	gonadotropin releasing hormone 1	Mus musculus	211-215
9888864-1	1999	We have characterized the regulation of plasminogen activator inhibitor-1 (PAI-1) gene expression by phorbol 12-myristate 13-acetate (PMA), serum, and interleukin-1alpha (IL-1alpha) in the human hepatoma cell line HepG2.	Tetradecanoylphorbol Acetate	101-132	serpin family E member 1	Homo sapiens	40-73
9888864-1	1999	We have characterized the regulation of plasminogen activator inhibitor-1 (PAI-1) gene expression by phorbol 12-myristate 13-acetate (PMA), serum, and interleukin-1alpha (IL-1alpha) in the human hepatoma cell line HepG2.	Tetradecanoylphorbol Acetate	101-132	serpin family E member 1	Homo sapiens	75-80
9888864-1	1999	We have characterized the regulation of plasminogen activator inhibitor-1 (PAI-1) gene expression by phorbol 12-myristate 13-acetate (PMA), serum, and interleukin-1alpha (IL-1alpha) in the human hepatoma cell line HepG2.	Tetradecanoylphorbol Acetate	134-137	serpin family E member 1	Homo sapiens	40-73
9888864-1	1999	We have characterized the regulation of plasminogen activator inhibitor-1 (PAI-1) gene expression by phorbol 12-myristate 13-acetate (PMA), serum, and interleukin-1alpha (IL-1alpha) in the human hepatoma cell line HepG2.	Tetradecanoylphorbol Acetate	134-137	serpin family E member 1	Homo sapiens	75-80
9888864-6	1999	This region of the PAI-1 promoter was previously found to contain a tetradecanoyl phorbol acetate-response element (TRE; between -58 and -50) necessary for PMA responsiveness and with a high affinity for c-Jun homodimers.	Tetradecanoylphorbol Acetate	68-97	serpin family E member 1	Homo sapiens	19-24
9858479-8	1999	Phorbol 12-myristate 13-acetate also significantly stimulated the activity of gelatinases A and B and TIMP-1 in conditioned medium and of TIMP-3 in ECM (p &lt; 0.05).	Tetradecanoylphorbol Acetate	0-31	92 kDa gelatinase	Equus caballus	78-97
9858479-8	1999	Phorbol 12-myristate 13-acetate also significantly stimulated the activity of gelatinases A and B and TIMP-1 in conditioned medium and of TIMP-3 in ECM (p &lt; 0.05).	Tetradecanoylphorbol Acetate	0-31	TIMP metallopeptidase inhibitor 3	Equus caballus	138-144
10423274-9	1999	When cells were preincubated with the phosphatidylinositide 3-kinase (PI3K) inhibitors wortmannin or LY294002, the PMA-induced GC morphological changes were inhibited but not membrane ruffles.	Tetradecanoylphorbol Acetate	115-118	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	38-68
9933103-5	1999	Expression of both the intracellular and secreted IL-1ra was detected in unstimulated and IL-1beta- or phorbol 12-myristate 13-acetate-exposed RPE.	Tetradecanoylphorbol Acetate	103-134	interleukin 1 receptor antagonist	Homo sapiens	50-56
9923449-10	1999	Addition of phorbol myristate acetate resulted in the redistribution of P-selectin (CD62) from the alpha granule to the platelet surface as detected by MoAbs S12 and G5 in three-color flow cytometry analyses.	Tetradecanoylphorbol Acetate	12-37	selectin P	Homo sapiens	72-82
9923449-10	1999	Addition of phorbol myristate acetate resulted in the redistribution of P-selectin (CD62) from the alpha granule to the platelet surface as detected by MoAbs S12 and G5 in three-color flow cytometry analyses.	Tetradecanoylphorbol Acetate	12-37	selectin P	Homo sapiens	84-88
9880335-5	1999	Second, in polarized Madin-Darby canine kidney (MDCK) cells, which expressed human uPAR apically, the low basal rate of uPAR ligand endocytosis, which could not be inhibited by RAP, was increased by forskolin or phorbol ester (phorbol 12-myristate 13-acetate), which selectively up-regulate clathrin-independent endocytosis from the apical domain of epithelial cells.	Tetradecanoylphorbol Acetate	227-258	plasminogen activator, urokinase receptor	Homo sapiens	83-87
9880335-5	1999	Second, in polarized Madin-Darby canine kidney (MDCK) cells, which expressed human uPAR apically, the low basal rate of uPAR ligand endocytosis, which could not be inhibited by RAP, was increased by forskolin or phorbol ester (phorbol 12-myristate 13-acetate), which selectively up-regulate clathrin-independent endocytosis from the apical domain of epithelial cells.	Tetradecanoylphorbol Acetate	227-258	plasminogen activator, urokinase receptor	Homo sapiens	120-124
9878549-4	1998	Our studies show that expression of NJ-1 antigen is upregulated in a murine megakaryoblastic cell line, L8057, when it differentiates into a megakaryocytic lineage in response to 12-O-tetradecanoyl phorbol-13-acetate.	Tetradecanoylphorbol Acetate	179-216	mucin 13, epithelial transmembrane	Mus musculus	36-40
9857183-0	1998	A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.	Tetradecanoylphorbol Acetate	85-88	ADAM metallopeptidase domain 9	Homo sapiens	31-35
9857183-0	1998	A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.	Tetradecanoylphorbol Acetate	85-88	ADAM metallopeptidase domain 9	Homo sapiens	50-55
9857183-0	1998	A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.	Tetradecanoylphorbol Acetate	85-88	heparin binding EGF like growth factor	Homo sapiens	138-176
9857183-2	1998	One such protein is the heparin-binding EGF-like growth factor (HB-EGF) that exists in a membrane-anchored form which is converted to a soluble form upon cell stimulation with TPA, an activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	176-179	heparin binding EGF like growth factor	Homo sapiens	24-62
9857183-2	1998	One such protein is the heparin-binding EGF-like growth factor (HB-EGF) that exists in a membrane-anchored form which is converted to a soluble form upon cell stimulation with TPA, an activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	176-179	heparin binding EGF like growth factor	Homo sapiens	64-70
9857183-4	1998	Furthermore, the presence of constitutively active PKCdelta or MDC9 results in the shedding of the ectodomain of proHB-EGF, whereas MDC9 mutants lacking the metalloprotease domain, as well as kinase-negative PKCdelta, suppress the TPA-induced shedding of the ectodomain.	Tetradecanoylphorbol Acetate	231-234	ADAM metallopeptidase domain 9	Homo sapiens	63-67
10381133-3	1998	TPA treatment also elevates the expression of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), c-myc, c-fos, c-jun, transforming growth factor-beta1 (TGF-beta1) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 1	Mus musculus	46-62
10381133-3	1998	TPA treatment also elevates the expression of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), c-myc, c-fos, c-jun, transforming growth factor-beta1 (TGF-beta1) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	0-3	FBJ osteosarcoma oncogene	Mus musculus	105-110
10381133-6	1998	As judged by reverse transcriptase-polymerase chain reaction (RT-PCR), TPA-induced increases in the expression of c-fos and TGF-beta1 were selectively inhibited.	Tetradecanoylphorbol Acetate	71-74	FBJ osteosarcoma oncogene	Mus musculus	114-119
9834270-9	1998	Transcription of intracellular IL-1Ra I mRNA was significantly up-regulated with inflammation and in vitro by phorbol myristate acetate and interleukin 1beta.	Tetradecanoylphorbol Acetate	110-135	interleukin 1 receptor antagonist	Homo sapiens	31-37
9844106-4	1998	During a 3-day treatment with phorbol 12-myristate, 13-acetate (PMA), which induces differentiation of FLG 29.1 cells toward an osteoclast-like phenotype, the levels of Src and Fyn increased and the levels of Lyn decreased.	Tetradecanoylphorbol Acetate	64-67	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	177-180
9877448-4	1998	Both IL-1alpha and IL-1beta were detected in the GCM after the cells had been cultured with PMA, suggesting that IL-1 elaboration required PMA treatment.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 alpha	Homo sapiens	5-14
9819402-3	1998	To investigate this issue, we performed a detailed comparative analysis of the promoter regulating the two-signal-dependent (Ca2+ ionophore plus phorbol myristate acetate [PMA]), CsA-sensitive expression of EGR3 in T cells and the one-signal-dependent (PMA), CsA-insensitive expression of EGR3 in fibroblasts.	Tetradecanoylphorbol Acetate	145-170	early growth response 3	Homo sapiens	207-211
9819402-3	1998	To investigate this issue, we performed a detailed comparative analysis of the promoter regulating the two-signal-dependent (Ca2+ ionophore plus phorbol myristate acetate [PMA]), CsA-sensitive expression of EGR3 in T cells and the one-signal-dependent (PMA), CsA-insensitive expression of EGR3 in fibroblasts.	Tetradecanoylphorbol Acetate	172-175	early growth response 3	Homo sapiens	207-211
9819402-3	1998	To investigate this issue, we performed a detailed comparative analysis of the promoter regulating the two-signal-dependent (Ca2+ ionophore plus phorbol myristate acetate [PMA]), CsA-sensitive expression of EGR3 in T cells and the one-signal-dependent (PMA), CsA-insensitive expression of EGR3 in fibroblasts.	Tetradecanoylphorbol Acetate	253-256	early growth response 3	Homo sapiens	207-211
9826532-0	1998	PMA inhibits both spontaneous and glucocorticoid-mediated leptin secretion by human omental adipose tissue explants in vitro.	Tetradecanoylphorbol Acetate	0-3	leptin	Homo sapiens	58-64
9806749-5	1998	P-selectin-dependent adhesion was tested on immobilized platelets treated with or without phorbol myristate acetate (10(-7) M, 10 min).	Tetradecanoylphorbol Acetate	90-115	selectin P	Homo sapiens	0-10
9772291-9	1998	TPA, a known AP-1 activator and tumor-promoting phorbol ester, also induced ERCC-1 protein to the same extent as cisplatin, but did not synergize with cisplatin in this regard.	Tetradecanoylphorbol Acetate	0-3	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	76-82
9794432-2	1998	IFN-gamma and TNF-alpha, alone or in combination, caused a significant up-regulation of the NADPH oxidase system as reflected by an enhancement of the PMA-stimulated superoxide release, cytochrome b558 content, and expression of gp91-phox and p47-phox genes on both days 2 and 7 of cell culture.	Tetradecanoylphorbol Acetate	151-154	pleckstrin	Homo sapiens	243-246
9794433-6	1998	4) In PMA-stimulated B cells from an X91+ CGD patient in which p22phox was normally expressed and gp91phox was present but lacked five amino acids, translocation of p47phox to the membranes was unaffected, but p67phox and p40phox were poorly translocated, and the production of O2- was greatly reduced with respect to that by normal B cells.	Tetradecanoylphorbol Acetate	6-9	cytochrome b-245 alpha chain	Homo sapiens	63-70
9794433-6	1998	4) In PMA-stimulated B cells from an X91+ CGD patient in which p22phox was normally expressed and gp91phox was present but lacked five amino acids, translocation of p47phox to the membranes was unaffected, but p67phox and p40phox were poorly translocated, and the production of O2- was greatly reduced with respect to that by normal B cells.	Tetradecanoylphorbol Acetate	6-9	neutrophil cytosolic factor 4	Homo sapiens	222-229
9922051-10	1998	HOX B6 mRNA expression in NB4 and NKM-1 cultured with TPA decreased on day 3.	Tetradecanoylphorbol Acetate	54-57	homeobox B6	Homo sapiens	0-6
9922051-13	1998	HOX B6 mRNA expression decreased in monocytoid differentiation by TPA induction in NB4, HL-60 and NKM-1.	Tetradecanoylphorbol Acetate	66-69	homeobox B6	Homo sapiens	0-6
9802902-7	1998	However, treatment of ARNO transfectants with the PKC agonist phorbol 12-myristate 13-acetate results in the dramatic redistribution of ARNO, ARF6, and actin into membrane protrusions resembling lamellipodia.	Tetradecanoylphorbol Acetate	62-93	ADP ribosylation factor 6	Homo sapiens	142-146
9755123-4	1998	Treatment of rat glomerular epithelial cells (GEC) with phorbol 12-myristate 13-acetate (PMA) increased activity of the bcn-1 transcriptional element, within the context of the native laminin gamma1-chain promoter or when cloned upstream of a heterologous promoter.	Tetradecanoylphorbol Acetate	56-87	laminin subunit gamma 1	Rattus norvegicus	184-198
9755123-4	1998	Treatment of rat glomerular epithelial cells (GEC) with phorbol 12-myristate 13-acetate (PMA) increased activity of the bcn-1 transcriptional element, within the context of the native laminin gamma1-chain promoter or when cloned upstream of a heterologous promoter.	Tetradecanoylphorbol Acetate	89-92	laminin subunit gamma 1	Rattus norvegicus	184-198
9733851-4	1998	We report here that the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is capable of inducing BZLF1"s activity even further.	Tetradecanoylphorbol Acetate	76-79	protein Zta	Human gammaherpesvirus 4	104-109
9733851-7	1998	Phosphorylation of S186 per se interferes with the DNA binding affinity of BZLF1 in vitro but is mandatory for TPA-induced increase in DNA binding of BZLF1, as shown in gel retardation assays and reconstruction experiments with cellular extracts.	Tetradecanoylphorbol Acetate	111-114	protein Zta	Human gammaherpesvirus 4	150-155
9733851-8	1998	In transcriptional reporter assays, S186 is essential for the activation of BZLF1 by TPA.	Tetradecanoylphorbol Acetate	85-88	protein Zta	Human gammaherpesvirus 4	76-81
10443688-5	1999	In addition, we evaluated the effect of dexamethasone on phorbolmyristate-acetate-stimulated IL-1 receptor antagonist secretion by the human monocytic cell line U937.	Tetradecanoylphorbol Acetate	57-81	interleukin 1 receptor antagonist	Homo sapiens	93-117
10501656-0	1999	Re-expression of SPR1 in breast cancer cells by phorbol 12-myristate 13-acetate (PMA) or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter.	Tetradecanoylphorbol Acetate	48-79	psoriasis susceptibility 1 candidate 2	Homo sapiens	17-21
10501656-0	1999	Re-expression of SPR1 in breast cancer cells by phorbol 12-myristate 13-acetate (PMA) or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter.	Tetradecanoylphorbol Acetate	48-79	psoriasis susceptibility 1 candidate 2	Homo sapiens	148-152
10501656-0	1999	Re-expression of SPR1 in breast cancer cells by phorbol 12-myristate 13-acetate (PMA) or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter.	Tetradecanoylphorbol Acetate	81-84	psoriasis susceptibility 1 candidate 2	Homo sapiens	17-21
10501656-0	1999	Re-expression of SPR1 in breast cancer cells by phorbol 12-myristate 13-acetate (PMA) or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter.	Tetradecanoylphorbol Acetate	81-84	psoriasis susceptibility 1 candidate 2	Homo sapiens	148-152
10501656-8	1999	SPR1 presents an example of class II genes, since its expression was up-regulated in tumor cells by phorbol 12-myristate 13-acetate (PMA) or by ultraviolet (UV) irradiation.	Tetradecanoylphorbol Acetate	100-131	psoriasis susceptibility 1 candidate 2	Homo sapiens	0-4
10501656-8	1999	SPR1 presents an example of class II genes, since its expression was up-regulated in tumor cells by phorbol 12-myristate 13-acetate (PMA) or by ultraviolet (UV) irradiation.	Tetradecanoylphorbol Acetate	133-136	psoriasis susceptibility 1 candidate 2	Homo sapiens	0-4
10501656-19	1999	The expression of SPR1 could be induced in the 21MT-2 metastatic breast tumor cell line by PMA treatment or by short UV irradiation via a transcriptional mechanism.	Tetradecanoylphorbol Acetate	91-94	psoriasis susceptibility 1 candidate 2	Homo sapiens	18-22
10419468-7	1999	Unstimulated B-lymphoblastoid cells bound WOW-1 Fab poorly (apparent K(d) = 2.4 microM), but acute stimulation with phorbol 12-myristate 13-acetate increased receptor affinity &gt;30-fold (K(d) = 80 nM), with no change in receptor number.	Tetradecanoylphorbol Acetate	116-147	FA complementation group B	Homo sapiens	48-51
10472804-2	1999	AFB1 inhibited the phorbol-12myristate-13-acetate/i6nomycin (PMA/Io)-induced IL-2 mRNA expression in the murine thymocytes and Jurkat E6-1 cells as determined by qualitative RT-PCR, while no effect was observed in the EL4.IL-2 cells.	Tetradecanoylphorbol Acetate	19-49	interleukin 2	Mus musculus	77-81
10472804-2	1999	AFB1 inhibited the phorbol-12myristate-13-acetate/i6nomycin (PMA/Io)-induced IL-2 mRNA expression in the murine thymocytes and Jurkat E6-1 cells as determined by qualitative RT-PCR, while no effect was observed in the EL4.IL-2 cells.	Tetradecanoylphorbol Acetate	19-49	interleukin 2	Mus musculus	222-226
10472804-2	1999	AFB1 inhibited the phorbol-12myristate-13-acetate/i6nomycin (PMA/Io)-induced IL-2 mRNA expression in the murine thymocytes and Jurkat E6-1 cells as determined by qualitative RT-PCR, while no effect was observed in the EL4.IL-2 cells.	Tetradecanoylphorbol Acetate	61-64	interleukin 2	Mus musculus	77-81
10472804-2	1999	AFB1 inhibited the phorbol-12myristate-13-acetate/i6nomycin (PMA/Io)-induced IL-2 mRNA expression in the murine thymocytes and Jurkat E6-1 cells as determined by qualitative RT-PCR, while no effect was observed in the EL4.IL-2 cells.	Tetradecanoylphorbol Acetate	61-64	interleukin 2	Mus musculus	222-226
9802422-7	1998	Moreover, PMA induced the accumulation of mRNA corresponding in size to the neuronal NPY-mRNA.	Tetradecanoylphorbol Acetate	10-13	neuropeptide Y	Homo sapiens	85-88
9733728-8	1998	Co-transfection of the hINV promoter with dominant negative forms of Ras, MEKK1, MEK1, MEK7, MEK3, p38/RK, and c-Jun inhibit the TPA-dependent increase.	Tetradecanoylphorbol Acetate	129-132	mitogen-activated protein kinase kinase 1	Homo sapiens	81-85
21282359-3	2011	We showed that the expression of mda-7/IL-24 and IL-24 delE5, an mda-7/IL-24 splice variant, was induced in U937 and HL60 cells during 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated monocytic differentiation.	Tetradecanoylphorbol Acetate	135-171	interleukin 24	Homo sapiens	39-44
9739161-3	1998	T-Kininogen secretion by VSMC was markedly enhanced by the addition of lipopolysaccharide (LPS), angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) to the culture.	Tetradecanoylphorbol Acetate	122-153	kininogen 1	Rattus norvegicus	2-11
9739161-3	1998	T-Kininogen secretion by VSMC was markedly enhanced by the addition of lipopolysaccharide (LPS), angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) to the culture.	Tetradecanoylphorbol Acetate	155-158	kininogen 1	Rattus norvegicus	2-11
21282359-3	2011	We showed that the expression of mda-7/IL-24 and IL-24 delE5, an mda-7/IL-24 splice variant, was induced in U937 and HL60 cells during 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated monocytic differentiation.	Tetradecanoylphorbol Acetate	135-171	interleukin 24	Homo sapiens	49-60
21282359-3	2011	We showed that the expression of mda-7/IL-24 and IL-24 delE5, an mda-7/IL-24 splice variant, was induced in U937 and HL60 cells during 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated monocytic differentiation.	Tetradecanoylphorbol Acetate	135-171	interleukin 24	Homo sapiens	65-70
9731072-6	1998	Finally, we found that Rap1 is activated by both the Ca2+ ionophore ionomycin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), indicating that phospholipase C (PLC) activation leading to elevated levels of intracellular free Ca2+ and diacylglycerol (DAG) can mediate Rap1 activation.	Tetradecanoylphorbol Acetate	100-136	RAP1A, member of RAS oncogene family	Homo sapiens	23-27
21282359-3	2011	We showed that the expression of mda-7/IL-24 and IL-24 delE5, an mda-7/IL-24 splice variant, was induced in U937 and HL60 cells during 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated monocytic differentiation.	Tetradecanoylphorbol Acetate	135-171	interleukin 24	Homo sapiens	49-54
9731072-6	1998	Finally, we found that Rap1 is activated by both the Ca2+ ionophore ionomycin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), indicating that phospholipase C (PLC) activation leading to elevated levels of intracellular free Ca2+ and diacylglycerol (DAG) can mediate Rap1 activation.	Tetradecanoylphorbol Acetate	100-136	RAP1A, member of RAS oncogene family	Homo sapiens	284-288
9731072-6	1998	Finally, we found that Rap1 is activated by both the Ca2+ ionophore ionomycin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), indicating that phospholipase C (PLC) activation leading to elevated levels of intracellular free Ca2+ and diacylglycerol (DAG) can mediate Rap1 activation.	Tetradecanoylphorbol Acetate	138-141	RAP1A, member of RAS oncogene family	Homo sapiens	23-27
21282359-3	2011	We showed that the expression of mda-7/IL-24 and IL-24 delE5, an mda-7/IL-24 splice variant, was induced in U937 and HL60 cells during 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated monocytic differentiation.	Tetradecanoylphorbol Acetate	173-176	interleukin 24	Homo sapiens	33-38
9731072-6	1998	Finally, we found that Rap1 is activated by both the Ca2+ ionophore ionomycin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), indicating that phospholipase C (PLC) activation leading to elevated levels of intracellular free Ca2+ and diacylglycerol (DAG) can mediate Rap1 activation.	Tetradecanoylphorbol Acetate	138-141	RAP1A, member of RAS oncogene family	Homo sapiens	284-288
21282359-3	2011	We showed that the expression of mda-7/IL-24 and IL-24 delE5, an mda-7/IL-24 splice variant, was induced in U937 and HL60 cells during 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated monocytic differentiation.	Tetradecanoylphorbol Acetate	173-176	interleukin 24	Homo sapiens	39-44
21282359-3	2011	We showed that the expression of mda-7/IL-24 and IL-24 delE5, an mda-7/IL-24 splice variant, was induced in U937 and HL60 cells during 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated monocytic differentiation.	Tetradecanoylphorbol Acetate	173-176	interleukin 24	Homo sapiens	49-60
21282359-3	2011	We showed that the expression of mda-7/IL-24 and IL-24 delE5, an mda-7/IL-24 splice variant, was induced in U937 and HL60 cells during 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated monocytic differentiation.	Tetradecanoylphorbol Acetate	173-176	interleukin 24	Homo sapiens	65-70
9780230-3	1998	In this study, the effects of the protein kinase C (PKC) activator 12-O-tetradecanoyphorbol-13 acetate (TPA) on AR activity were tested.	Tetradecanoylphorbol Acetate	104-107	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	112-114
21282359-3	2011	We showed that the expression of mda-7/IL-24 and IL-24 delE5, an mda-7/IL-24 splice variant, was induced in U937 and HL60 cells during 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated monocytic differentiation.	Tetradecanoylphorbol Acetate	173-176	interleukin 24	Homo sapiens	49-54
9780230-4	1998	We demonstrated that in the absence of androgen, TPA enhanced AR-mediated transactivation by 10-12-fold.	Tetradecanoylphorbol Acetate	49-52	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	62-64
9780230-11	1998	Our results suggest that ligand-independent activation of the AR by TPA results from interaction of unliganded AR with other proteins in the transcription machinery.	Tetradecanoylphorbol Acetate	68-71	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	62-64
21282359-5	2011	Knockdown of mda-7/IL-24 and IL-24 delE5 resulted in significant inhibition of the monocytic differentiation induced by TPA.	Tetradecanoylphorbol Acetate	120-123	interleukin 24	Homo sapiens	13-18
9780230-11	1998	Our results suggest that ligand-independent activation of the AR by TPA results from interaction of unliganded AR with other proteins in the transcription machinery.	Tetradecanoylphorbol Acetate	68-71	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	111-113
21282359-5	2011	Knockdown of mda-7/IL-24 and IL-24 delE5 resulted in significant inhibition of the monocytic differentiation induced by TPA.	Tetradecanoylphorbol Acetate	120-123	interleukin 24	Homo sapiens	19-24
21282359-5	2011	Knockdown of mda-7/IL-24 and IL-24 delE5 resulted in significant inhibition of the monocytic differentiation induced by TPA.	Tetradecanoylphorbol Acetate	120-123	interleukin 24	Homo sapiens	29-34
21292826-6	2011	The SRF site alone is sufficient for induction by GnRH, whereas induction by 12-tetradecanoylphorbol-13-acetate (TPA) requires both the ELK1 and SRF sites.	Tetradecanoylphorbol Acetate	113-116	ELK1, member of ETS oncogene family	Mus musculus	136-140
9727032-8	1998	These results suggest that PKCepsilon is required for the protective effect of TPA in TNF-alpha- and calphostin C-induced apoptosis.	Tetradecanoylphorbol Acetate	79-82	protein kinase C epsilon	Homo sapiens	27-37
21148409-4	2011	After forskolin stimulation, TPA-induced ubiquitination of AQP2 preceded phosphorylation of AQP2 at S261, which in the first instance occurred predominantly on ubiquitinated AQP2.	Tetradecanoylphorbol Acetate	29-32	aquaporin 2	Canis lupus familiaris	92-96
9771965-4	1998	In the ML-1 human myeloblastic leukemia cell line, a rapid and sustained increase in phosphorylation of the extracellular signal-regulated kinase (ERK) members of the MAP kinase family was found to precede the increase in MCL1 expression produced by 12-O-tetradecanoylphorbol 13-acetate (TPA) or the microtubule-disrupting agents colchicine and vinblastine.	Tetradecanoylphorbol Acetate	250-286	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	222-226
9771965-4	1998	In the ML-1 human myeloblastic leukemia cell line, a rapid and sustained increase in phosphorylation of the extracellular signal-regulated kinase (ERK) members of the MAP kinase family was found to precede the increase in MCL1 expression produced by 12-O-tetradecanoylphorbol 13-acetate (TPA) or the microtubule-disrupting agents colchicine and vinblastine.	Tetradecanoylphorbol Acetate	288-291	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	222-226
9740146-10	1998	TPA (10 nmol/L) also stimulated the production of IL-6 and IL-8 by these cells, but inhibited that of monocyte chemoattractant protein-1.	Tetradecanoylphorbol Acetate	0-3	C-C motif chemokine ligand 2	Homo sapiens	102-136
21186251-6	2011	BAS 02104951 also inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Elk-1 phosphorylation in HeLa cells, translocation of PKCepsilon and PKCeta to the membrane following treatment of PC3 cells with TPA.	Tetradecanoylphorbol Acetate	66-69	protein kinase C epsilon	Homo sapiens	133-143
9802549-6	1998	Cytokines, IL-1 and TNF enhanced the hydroxyl radical formation in phorbol 12-myristate 13-acetate treated chondrocytes.	Tetradecanoylphorbol Acetate	67-98	interleukin 1 alpha	Homo sapiens	11-23
9767457-7	1998	Moreover extended studies demonstrated that in cultured rat spleen cells the expression of lymphotactin mRNA was markedly induced by phytohaemagglutinin (PHA) or phorbol myristate acetate (PMA), and such induction was inhibited by the immunosuppressive drugs FK506 and cyclosporin.	Tetradecanoylphorbol Acetate	162-187	X-C motif chemokine ligand 1	Rattus norvegicus	91-103
9767457-7	1998	Moreover extended studies demonstrated that in cultured rat spleen cells the expression of lymphotactin mRNA was markedly induced by phytohaemagglutinin (PHA) or phorbol myristate acetate (PMA), and such induction was inhibited by the immunosuppressive drugs FK506 and cyclosporin.	Tetradecanoylphorbol Acetate	189-192	X-C motif chemokine ligand 1	Rattus norvegicus	91-103
20935675-5	2011	Moreover, Tpl2(-/-) mice treated with TPA experienced significantly higher nuclear factor kappaB (NF-kappaB) activation, edema, infiltrating neutrophils and production of proinflammatory cytokines than did WT mice.	Tetradecanoylphorbol Acetate	38-41	mitogen-activated protein kinase kinase kinase 8	Mus musculus	10-14
9768595-11	1998	The selective PKC inhibitors, bis-indolylmaleimide II and Ro-31-8220 inhibited the phorbol 12-myristate 13-acetate-mediated cPLA2 electrophoretic mobility shift, but not the IL-3-mediated shift, suggesting that the IL-3 effect is PKC independent.	Tetradecanoylphorbol Acetate	83-114	interleukin 3	Homo sapiens	215-219
20959602-8	2011	Reciprocally, AP-1 TFs were up-regulated by RUNX1 after 12-O-tetradecanoylphorbol-13-acetate induction and recruited to RUNX1-occupied sites lacking AP-1 motifs.	Tetradecanoylphorbol Acetate	56-92	RUNX family transcription factor 1	Homo sapiens	44-49
9705334-1	1998	The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), enhances transcription of many eukaryotic genes, including that for dopamine beta-hydroxylase (DBH).	Tetradecanoylphorbol Acetate	19-55	dopamine beta-hydroxylase	Homo sapiens	131-156
9705334-1	1998	The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), enhances transcription of many eukaryotic genes, including that for dopamine beta-hydroxylase (DBH).	Tetradecanoylphorbol Acetate	19-55	dopamine beta-hydroxylase	Homo sapiens	158-161
9705334-1	1998	The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), enhances transcription of many eukaryotic genes, including that for dopamine beta-hydroxylase (DBH).	Tetradecanoylphorbol Acetate	57-60	dopamine beta-hydroxylase	Homo sapiens	131-156
9705334-1	1998	The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), enhances transcription of many eukaryotic genes, including that for dopamine beta-hydroxylase (DBH).	Tetradecanoylphorbol Acetate	57-60	dopamine beta-hydroxylase	Homo sapiens	158-161
9705334-5	1998	In addition, alteration of the YY1-binding site decreased TPA-mediated induction of the DBH promoter activity, suggesting that contiguous cis-regulatory element(s) cooperate with this novel sequence motif.	Tetradecanoylphorbol Acetate	58-61	dopamine beta-hydroxylase	Homo sapiens	88-91
20959602-8	2011	Reciprocally, AP-1 TFs were up-regulated by RUNX1 after 12-O-tetradecanoylphorbol-13-acetate induction and recruited to RUNX1-occupied sites lacking AP-1 motifs.	Tetradecanoylphorbol Acetate	56-92	RUNX family transcription factor 1	Homo sapiens	120-125
9705334-7	1998	Taken together, these data suggest that transcriptional up-regulation of the human DBH gene in response to TPA requires coordination of a novel TRE (human DBH TRE, hDTRE), cyclic AMP-responsive element, and the YY1-binding site.	Tetradecanoylphorbol Acetate	107-110	dopamine beta-hydroxylase	Homo sapiens	83-86
9705334-7	1998	Taken together, these data suggest that transcriptional up-regulation of the human DBH gene in response to TPA requires coordination of a novel TRE (human DBH TRE, hDTRE), cyclic AMP-responsive element, and the YY1-binding site.	Tetradecanoylphorbol Acetate	107-110	dopamine beta-hydroxylase	Homo sapiens	155-158
21224075-5	2011	12-O-tetradecanoylphorbol-13-acetate stimulated skin fibroblasts, secreting high levels of monocyte chemotactic protein-1, and neutralization of this chemokine eliminated almost completely the fibroblast-induced chemotaxis of macrophages.	Tetradecanoylphorbol Acetate	0-36	C-C motif chemokine ligand 2	Homo sapiens	91-121
9689135-7	1998	Finally, we established that photonic activity accurately reflected endogenous GnRH gene expression by treating transfected GT1-1 cells with phorbol 12-myristate 13 acetate (a consensus inhibitor of GnRH gene expression) and observing a dramatic suppression of photonic emissions from continuously monitored cells.	Tetradecanoylphorbol Acetate	141-172	gonadotropin releasing hormone 1	Mus musculus	79-83
21076887-4	2011	Using chemical inhibitors and antibodies against PKCs, delivered into cells by the Chariot transfection system, we found that nPKCs activate ERK through transphosphorylation of PKD1, the blockage of which prevented PMA-stimulated ERK activation.	Tetradecanoylphorbol Acetate	215-218	polycystin 1, transient receptor potential channel interacting	Homo sapiens	177-181
9689135-7	1998	Finally, we established that photonic activity accurately reflected endogenous GnRH gene expression by treating transfected GT1-1 cells with phorbol 12-myristate 13 acetate (a consensus inhibitor of GnRH gene expression) and observing a dramatic suppression of photonic emissions from continuously monitored cells.	Tetradecanoylphorbol Acetate	141-172	gonadotropin releasing hormone 1	Mus musculus	199-203
9619293-9	1998	Calmodulin, which binds to GAP-43 and inhibits its phosphorylation by protein kinase C, abolished the effect of TPA.	Tetradecanoylphorbol Acetate	112-115	growth associated protein 43	Homo sapiens	27-33
21858203-2	2011	Interaction of urokinase-type plasminogen activator (uPA) with its cell surface receptor (uPAR) has been shown to favor virion accumulation in such sub-cellular compartment in primary monocyte-derived macrophages and chronically infected promonocytic U1 cells differentiated into macrophage-like cells by stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	322-347	CD177 molecule	Homo sapiens	67-88
9683525-0	1998	Regulation of the cell cycle at the G2/M boundary in metastatic melanoma cells by 12-O-tetradecanoyl phorbol-13-acetate (TPA) by blocking p34cdc2 kinase activity.	Tetradecanoylphorbol Acetate	82-119	cyclin dependent kinase 1	Homo sapiens	138-145
21131700-6	2010	In contrast to the differential effect of GM-CSF on neutrophils versus eosinophils, stimulation with phorbol myristate acetate demonstrated a similar degree of inhibition of rolling and L-selectin shedding by neutrophils and eosinophils suggesting that there was no defect in L-selectin shedding in the eosinophil donors who did not respond to GM-CSF.	Tetradecanoylphorbol Acetate	101-126	selectin L	Homo sapiens	186-196
9683525-0	1998	Regulation of the cell cycle at the G2/M boundary in metastatic melanoma cells by 12-O-tetradecanoyl phorbol-13-acetate (TPA) by blocking p34cdc2 kinase activity.	Tetradecanoylphorbol Acetate	121-124	cyclin dependent kinase 1	Homo sapiens	138-145
9683525-7	1998	Examination of the levels of cyclins A and B1 demonstrated that the levels of these cyclins were not limiting for entrance into M. However, the addition of TPA blocked the increase in p34(cdc2)/cyclin B1 kinase activity.	Tetradecanoylphorbol Acetate	156-159	cyclin dependent kinase 1	Homo sapiens	188-192
9683525-7	1998	Examination of the levels of cyclins A and B1 demonstrated that the levels of these cyclins were not limiting for entrance into M. However, the addition of TPA blocked the increase in p34(cdc2)/cyclin B1 kinase activity.	Tetradecanoylphorbol Acetate	156-159	cyclin B1	Homo sapiens	194-203
9683525-8	1998	In cells treated with TPA, most p34(cdc2) was found in the slowly migrating forms on Western blots, which contained increased levels of phosphotyrosine.	Tetradecanoylphorbol Acetate	22-25	cyclin dependent kinase 1	Homo sapiens	36-40
9668098-3	1998	We have also observed a significant up-regulation of FGF-BP during TPA (12-O-tetradecanoylphorbol-13-acetate) promotion of skin cancer.	Tetradecanoylphorbol Acetate	67-70	fibroblast growth factor binding protein 1	Homo sapiens	53-59
9668098-3	1998	We have also observed a significant up-regulation of FGF-BP during TPA (12-O-tetradecanoylphorbol-13-acetate) promotion of skin cancer.	Tetradecanoylphorbol Acetate	72-108	fibroblast growth factor binding protein 1	Homo sapiens	53-59
9668098-4	1998	Here we investigate the mechanism of TPA induction of FGF-BP gene expression in the human ME-180 SCC cell line.	Tetradecanoylphorbol Acetate	37-40	fibroblast growth factor binding protein 1	Homo sapiens	54-60
21131700-6	2010	In contrast to the differential effect of GM-CSF on neutrophils versus eosinophils, stimulation with phorbol myristate acetate demonstrated a similar degree of inhibition of rolling and L-selectin shedding by neutrophils and eosinophils suggesting that there was no defect in L-selectin shedding in the eosinophil donors who did not respond to GM-CSF.	Tetradecanoylphorbol Acetate	101-126	selectin L	Homo sapiens	276-286
21131700-6	2010	In contrast to the differential effect of GM-CSF on neutrophils versus eosinophils, stimulation with phorbol myristate acetate demonstrated a similar degree of inhibition of rolling and L-selectin shedding by neutrophils and eosinophils suggesting that there was no defect in L-selectin shedding in the eosinophil donors who did not respond to GM-CSF.	Tetradecanoylphorbol Acetate	101-126	colony stimulating factor 2	Homo sapiens	344-350
9668098-5	1998	We found that TPA increased FGF-BP mRNA levels in a time- and dose-dependent manner mediated via the protein kinase C signal transduction pathway.	Tetradecanoylphorbol Acetate	14-17	fibroblast growth factor binding protein 1	Homo sapiens	28-34
9668098-6	1998	Results from actinomycin D and cycloheximide experiments as well as nuclear transcription assays revealed that TPA up-regulated the steady-state levels of FGF-BP mRNA by increasing its rate of gene transcription independently of de novo protein synthesis.	Tetradecanoylphorbol Acetate	111-114	fibroblast growth factor binding protein 1	Homo sapiens	155-161
9668098-7	1998	We isolated the human FGF-BP promoter and determined by deletion analysis that TPA regulatory elements were all contained in the first 118 base pairs upstream of the transcription start site.	Tetradecanoylphorbol Acetate	79-82	fibroblast growth factor binding protein 1	Homo sapiens	22-28
20709134-0	2010	Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.	Tetradecanoylphorbol Acetate	57-93	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	11-16
9668098-9	1998	In addition, deletion or mutation of a 10-base pair region juxtaposed to the AP-1 site dramatically increased TPA induced FGF-BP gene expression.	Tetradecanoylphorbol Acetate	110-113	fibroblast growth factor binding protein 1	Homo sapiens	122-128
9668098-10	1998	This region represses the extent of the FGF-BP promoter response to TPA and contained sequences recognized by the family of E box helix-loop-helix transcription factors.	Tetradecanoylphorbol Acetate	68-71	fibroblast growth factor binding protein 1	Homo sapiens	40-46
9668098-13	1998	Overall, our data indicate that TPA effects on FGF-BP gene transcription are tightly controlled by a complex interplay of positive elements and a novel negative regulatory element.	Tetradecanoylphorbol Acetate	32-35	fibroblast growth factor binding protein 1	Homo sapiens	47-53
20709134-0	2010	Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.	Tetradecanoylphorbol Acetate	57-93	ribosomal protein S3	Mus musculus	17-37
20709134-0	2010	Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.	Tetradecanoylphorbol Acetate	57-93	ribosomal protein S3	Mus musculus	39-43
20709134-1	2010	This study investigated the preventive effect of ribosomal protein S3 (rpS3) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice.	Tetradecanoylphorbol Acetate	80-116	ribosomal protein S3	Mus musculus	49-69
20709134-1	2010	This study investigated the preventive effect of ribosomal protein S3 (rpS3) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice.	Tetradecanoylphorbol Acetate	80-116	ribosomal protein S3	Mus musculus	71-75
9783907-9	1998	AlphaT3-1 cells possess several PKC isoforms which, except PKCzeta, were differentially down-regulated by TPA (PKCalpha, betaII, delta, epsilon, eta) or GnRH (PKCbetaII, delta, epsilon, eta).	Tetradecanoylphorbol Acetate	106-109	gonadotropin releasing hormone 1	Mus musculus	111-190
20732874-5	2010	Activation of PKCs by phorbol 12-myristate 13-acetate (PMA) caused a redistribution of NKCC1 immunostaining from the basolateral membrane to intracellular vesicles in both shLacZ- and shPKCalpha-T84 cells, whereas the effect of PMA was not observed in shPKCdelta- and shPKCepsilon- cells.	Tetradecanoylphorbol Acetate	22-53	solute carrier family 12 member 2	Homo sapiens	87-92
9783907-11	1998	In conclusion, in alphaT3-1 cells the GnRH-induced homologous desensitization affects the GnRH coupling with PLC, PLA2 and PLD by mechanism(s) which do not implicate TPA-sensitive PKC isoforms, but likely reflect time-dependent modification(s) on the activation processes of the enzymes.	Tetradecanoylphorbol Acetate	166-169	gonadotropin releasing hormone 1	Mus musculus	38-42
9671751-2	1998	We have used stable transfection assays to show that activation of the mitogen-activated protein (MAP) kinase pathway by low concentrations of the phorbol ester phorbol 12-tetradecanoate 13-acetate (TPA) induces enhancer activity of the LCR subregion HS2, but not HS3.	Tetradecanoylphorbol Acetate	161-197	spectrin beta, erythrocytic	Homo sapiens	251-254
9671751-2	1998	We have used stable transfection assays to show that activation of the mitogen-activated protein (MAP) kinase pathway by low concentrations of the phorbol ester phorbol 12-tetradecanoate 13-acetate (TPA) induces enhancer activity of the LCR subregion HS2, but not HS3.	Tetradecanoylphorbol Acetate	199-202	spectrin beta, erythrocytic	Homo sapiens	251-254
10400642-3	1999	Here we show that this attenuation of tyrosine phosphorylation of Shc, CrkL, and the proto-oncogene Cbl is mimicked by treatment of mouse T lymphocytes or cultured Jurkat cells with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	182-213	v-crk avian sarcoma virus CT10 oncogene homolog-like	Mus musculus	71-75
10400642-3	1999	Here we show that this attenuation of tyrosine phosphorylation of Shc, CrkL, and the proto-oncogene Cbl is mimicked by treatment of mouse T lymphocytes or cultured Jurkat cells with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	182-213	Casitas B-lineage lymphoma	Mus musculus	100-103
20732874-5	2010	Activation of PKCs by phorbol 12-myristate 13-acetate (PMA) caused a redistribution of NKCC1 immunostaining from the basolateral membrane to intracellular vesicles in both shLacZ- and shPKCalpha-T84 cells, whereas the effect of PMA was not observed in shPKCdelta- and shPKCepsilon- cells.	Tetradecanoylphorbol Acetate	55-58	solute carrier family 12 member 2	Homo sapiens	87-92
20732874-5	2010	Activation of PKCs by phorbol 12-myristate 13-acetate (PMA) caused a redistribution of NKCC1 immunostaining from the basolateral membrane to intracellular vesicles in both shLacZ- and shPKCalpha-T84 cells, whereas the effect of PMA was not observed in shPKCdelta- and shPKCepsilon- cells.	Tetradecanoylphorbol Acetate	228-231	solute carrier family 12 member 2	Homo sapiens	87-92
11228744-5	1999	Addition of hTRX/ADF clearly suppressed lytic replication of EBV in Raji cells and B95-8 cells induced to the lytic phase of 12-O-tetradecanoylphorbol-13-acetate (TPA), and it prevented the death of these cells evoked by the lytic induction.	Tetradecanoylphorbol Acetate	125-161	thioredoxin	Homo sapiens	12-16
11228744-5	1999	Addition of hTRX/ADF clearly suppressed lytic replication of EBV in Raji cells and B95-8 cells induced to the lytic phase of 12-O-tetradecanoylphorbol-13-acetate (TPA), and it prevented the death of these cells evoked by the lytic induction.	Tetradecanoylphorbol Acetate	125-161	thioredoxin	Homo sapiens	17-20
9721047-9	1998	Treatment with a lower concentration of PMA (10 nM) translocated the protein kinase C-epsilon within 2 min, while it had little effect on the translocation of protein kinase C-alpha and -beta up to 20 min.	Tetradecanoylphorbol Acetate	40-43	protein kinase C epsilon	Homo sapiens	69-93
9721047-10	1998	However, simultaneous treatment with 10 nM PMA plus histamine for 5 min significantly inhibited the histamine-mediated cAMP generation, indicating that the protein kinase C-epsilon could be involved in the inhibition of receptor-mediated cAMP generation.	Tetradecanoylphorbol Acetate	43-46	protein kinase C epsilon	Homo sapiens	156-180
9722021-1	1998	The aim of this study was to evaluate the inhibitory activity of adenosine on tumor necrosis factor-alpha (TNF), thrombin-, or phorbol 12-myristate 13-acetate (PMA)-induced tissue factor (TF) expression on human umbilical vein endothelial cells (HUVECs).	Tetradecanoylphorbol Acetate	127-158	coagulation factor III, tissue factor	Homo sapiens	173-186
20524209-5	2010	We found that PKC and mitogen-activating protein/ERK2 kinase are essential for PMA-induced lysozyme expression and also mediate the PMA-induced activation of c-Myb protein.	Tetradecanoylphorbol Acetate	79-82	MYB proto-oncogene, transcription factor	Homo sapiens	158-163
9722021-1	1998	The aim of this study was to evaluate the inhibitory activity of adenosine on tumor necrosis factor-alpha (TNF), thrombin-, or phorbol 12-myristate 13-acetate (PMA)-induced tissue factor (TF) expression on human umbilical vein endothelial cells (HUVECs).	Tetradecanoylphorbol Acetate	160-163	coagulation factor III, tissue factor	Homo sapiens	173-186
9651321-11	1998	Deletion analyses of the p2672CAT vector demonstrated that TRE-2, which was located between -272 and -278, was critical for the regulation by TPA.	Tetradecanoylphorbol Acetate	142-145	ubiquitin specific peptidase 6	Homo sapiens	59-64
9665805-4	1998	Upon induction by TPA of an inflammatory epidermal hyperplasia (regenerative hyperplasia) the number of PGHS-2-expressing keratinocytes scattered throughout the basal but not the suprabasal compartment of the interfollicular epidermis was found to be increased while PGHS-1 expression remained unchanged.	Tetradecanoylphorbol Acetate	18-21	prostaglandin-endoperoxide synthase 1	Mus musculus	267-273
11228744-5	1999	Addition of hTRX/ADF clearly suppressed lytic replication of EBV in Raji cells and B95-8 cells induced to the lytic phase of 12-O-tetradecanoylphorbol-13-acetate (TPA), and it prevented the death of these cells evoked by the lytic induction.	Tetradecanoylphorbol Acetate	163-166	thioredoxin	Homo sapiens	12-16
11228744-5	1999	Addition of hTRX/ADF clearly suppressed lytic replication of EBV in Raji cells and B95-8 cells induced to the lytic phase of 12-O-tetradecanoylphorbol-13-acetate (TPA), and it prevented the death of these cells evoked by the lytic induction.	Tetradecanoylphorbol Acetate	163-166	thioredoxin	Homo sapiens	17-20
20524209-5	2010	We found that PKC and mitogen-activating protein/ERK2 kinase are essential for PMA-induced lysozyme expression and also mediate the PMA-induced activation of c-Myb protein.	Tetradecanoylphorbol Acetate	132-135	MYB proto-oncogene, transcription factor	Homo sapiens	158-163
10373480-3	1999	Direct activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) also induces myosin light chain phosphorylation and myosin reorganization in CHO-m3 cells.	Tetradecanoylphorbol Acetate	49-80	myosin heavy chain 14	Homo sapiens	100-106
20524209-9	2010	From these results, we conclude that PMA induces overexpression of lysozyme via ERK1/2 MAP kinase-c-Myb signaling pathways in NCI-H292 cells.	Tetradecanoylphorbol Acetate	37-40	MYB proto-oncogene, transcription factor	Homo sapiens	98-103
10373480-3	1999	Direct activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) also induces myosin light chain phosphorylation and myosin reorganization in CHO-m3 cells.	Tetradecanoylphorbol Acetate	49-80	myosin heavy chain 14	Homo sapiens	139-145
9692546-4	1998	HMG-I(Y) mRNAs were induced to higher levels by the tumor promoter 12-O-tetradecanoylphorbol acetate (TPA) and were sustained longer in P+ than in P- cells.	Tetradecanoylphorbol Acetate	67-100	high mobility group AT-hook 1	Homo sapiens	0-8
9692546-4	1998	HMG-I(Y) mRNAs were induced to higher levels by the tumor promoter 12-O-tetradecanoylphorbol acetate (TPA) and were sustained longer in P+ than in P- cells.	Tetradecanoylphorbol Acetate	102-105	high mobility group AT-hook 1	Homo sapiens	0-8
10373480-3	1999	Direct activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) also induces myosin light chain phosphorylation and myosin reorganization in CHO-m3 cells.	Tetradecanoylphorbol Acetate	82-85	myosin heavy chain 14	Homo sapiens	100-106
20735053-5	2010	Furthermore, steady-state fluorescence excitation anisotropy and quantum chemical calculation are also employed to determine the structure-related mechanism of these dendrimers with gigantic TPA cross sections and high TPEF efficiency.	Tetradecanoylphorbol Acetate	191-194	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	219-223
10373480-3	1999	Direct activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) also induces myosin light chain phosphorylation and myosin reorganization in CHO-m3 cells.	Tetradecanoylphorbol Acetate	82-85	myosin heavy chain 14	Homo sapiens	139-145
9661070-9	1998	Twenty-four hours of PMA pretreatment blocked the induction of PGHS-2 by PMA but not by IL-1, suggesting that IL-1 induction of PGHS-2 mRNA is not dependent on the protein kinase C pathway.	Tetradecanoylphorbol Acetate	21-24	interleukin 1 alpha	Homo sapiens	110-114
10364183-8	1999	Our observations are consistent with this idea and suggest that the equilibrium involves partial insertion of the RCL into sheet A: latent, RCL-cleaved, and tPA-complexed PAI-1, which are inactive loop-inserted forms, bound much faster than active PAI-1 to MA-33B8, whereas two loop-extracted forms of PAI-1, modified to prevent loop insertion, did not bind or bound much more weakly to the antibody.	Tetradecanoylphorbol Acetate	157-160	serpin family E member 1	Homo sapiens	171-176
19855086-3	2010	TGF-beta, phorbol myristate acetate, and the translation inhibitor cycloheximide induced PAI-1 mRNA and slowed its degradation, suggesting that PAI-1 mRNA could be regulated by interaction of a PAI-1 binding protein (PAI-1 mRNABp) with PAI-1 mRNA.	Tetradecanoylphorbol Acetate	10-35	serpin family E member 1	Homo sapiens	89-94
10364183-8	1999	Our observations are consistent with this idea and suggest that the equilibrium involves partial insertion of the RCL into sheet A: latent, RCL-cleaved, and tPA-complexed PAI-1, which are inactive loop-inserted forms, bound much faster than active PAI-1 to MA-33B8, whereas two loop-extracted forms of PAI-1, modified to prevent loop insertion, did not bind or bound much more weakly to the antibody.	Tetradecanoylphorbol Acetate	157-160	serpin family E member 1	Homo sapiens	248-253
10364183-8	1999	Our observations are consistent with this idea and suggest that the equilibrium involves partial insertion of the RCL into sheet A: latent, RCL-cleaved, and tPA-complexed PAI-1, which are inactive loop-inserted forms, bound much faster than active PAI-1 to MA-33B8, whereas two loop-extracted forms of PAI-1, modified to prevent loop insertion, did not bind or bound much more weakly to the antibody.	Tetradecanoylphorbol Acetate	157-160	serpin family E member 1	Homo sapiens	248-253
10365914-7	1999	Analysis of the IGF-1 receptor (IGF-1r) and epidermal growth factor (EGFr) in the epidermis of TPA-treated HK1.IGF-1 transgenic and non-transgenic mice revealed that both receptors were activated (hyperphosphorylated on tyrosine residues), and the level of activation was higher in transgenic mice.	Tetradecanoylphorbol Acetate	95-98	epidermal growth factor	Mus musculus	69-73
9614208-5	1998	The response of prolactin mRNA to TGF-beta2 was inhibited by preincubation of cells with phorbol-12-myristate-13-acetate, which down-regulated protein kinase C (PKC).	Tetradecanoylphorbol Acetate	89-120	transforming growth factor, beta 2	Rattus norvegicus	34-43
10327418-5	1998	Phorbol myristate acetate, a protein kinase C activator, reduced C1q expression.	Tetradecanoylphorbol Acetate	0-25	complement C1q A chain	Homo sapiens	65-68
9619855-5	1998	The cyclic AMP inducer, forskolin, and the activator of protein kinase C, phorbol 12-myristate 13-acetate, also stimulated the production of Il-11.	Tetradecanoylphorbol Acetate	74-105	interleukin 11	Homo sapiens	141-146
19855086-3	2010	TGF-beta, phorbol myristate acetate, and the translation inhibitor cycloheximide induced PAI-1 mRNA and slowed its degradation, suggesting that PAI-1 mRNA could be regulated by interaction of a PAI-1 binding protein (PAI-1 mRNABp) with PAI-1 mRNA.	Tetradecanoylphorbol Acetate	10-35	serpin family E member 1	Homo sapiens	144-149
19855086-3	2010	TGF-beta, phorbol myristate acetate, and the translation inhibitor cycloheximide induced PAI-1 mRNA and slowed its degradation, suggesting that PAI-1 mRNA could be regulated by interaction of a PAI-1 binding protein (PAI-1 mRNABp) with PAI-1 mRNA.	Tetradecanoylphorbol Acetate	10-35	serpin family E member 1	Homo sapiens	144-149
19855086-3	2010	TGF-beta, phorbol myristate acetate, and the translation inhibitor cycloheximide induced PAI-1 mRNA and slowed its degradation, suggesting that PAI-1 mRNA could be regulated by interaction of a PAI-1 binding protein (PAI-1 mRNABp) with PAI-1 mRNA.	Tetradecanoylphorbol Acetate	10-35	serpin family E member 1	Homo sapiens	144-149
9627115-5	1998	Disruption of E2F1 had the most profound effect on melanocyte growth, resulting in a fourfold decrease in growth rate in the presence of TPA.	Tetradecanoylphorbol Acetate	137-140	E2F transcription factor 1	Mus musculus	14-18
9627115-6	1998	Furthermore, enforced overexpression of the DNA-binding-defective E2F1E132 mutant conferred TPA-independence upon melanocytes and was associated with sequestration of Rb and constitutive expression of E2F1 target genes, including p21WAF1/CIP1.	Tetradecanoylphorbol Acetate	92-95	E2F transcription factor 1	Mus musculus	66-70
10499814-7	1999	In addition we show that TRAF1 mRNA is not expressed in non-stimulated lymphocytes but can be induced upon activation with different stimuli, including anti-CD3, anti-IgM, anti-CD40 antibodies, LPS, or a combination of phorbol-12-myristate-13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	219-250	TNF receptor-associated factor 1	Mus musculus	25-30
19855086-3	2010	TGF-beta, phorbol myristate acetate, and the translation inhibitor cycloheximide induced PAI-1 mRNA and slowed its degradation, suggesting that PAI-1 mRNA could be regulated by interaction of a PAI-1 binding protein (PAI-1 mRNABp) with PAI-1 mRNA.	Tetradecanoylphorbol Acetate	10-35	serpin family E member 1	Homo sapiens	144-149
20660715-3	2010	Here, we report that capsaicin has a cocarcinogenic effect on 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis in vivo and is mediated through the epidermal growth factor receptor (EGFR), but not the transient receptor potential vanilloid subfamily member 1 (TRPV1).	Tetradecanoylphorbol Acetate	62-98	epidermal growth factor receptor	Mus musculus	170-202
10233882-3	1999	We provide evidence here that virtually all human CD34(+) bone marrow cells express NF-kappaB that can be activated by exposure to phorbol 12-myristate 13-acetate and a variety of cytokines, eg, tumor necrosis factor alpha, interleukin-3, and granulocyte-macrophage colony-stimulating factor.	Tetradecanoylphorbol Acetate	131-162	interleukin 3	Homo sapiens	224-291
9612280-4	1998	However, TPA-induced alkalosis is not blocked by tyrosine kinase inhibitors; and 3) the stimulatory effect of EGF on the Na(+)-H+ exchanger acts via stimulation of tyrosine kinase-receptor activity because it is inhibited by tyrosine kinase inhibitors (genistein, lavendustin A, and herbimycin A).	Tetradecanoylphorbol Acetate	9-12	epidermal growth factor	Homo sapiens	110-113
10344756-3	1999	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced immediate early genes, such as c-Jun, c-Fos, and Egr-1 in activated Ki-ras-disrupted clones, whereas c-Jun induction was rare in HCT116.	Tetradecanoylphorbol Acetate	38-41	early growth response 1	Homo sapiens	100-105
20660715-3	2010	Here, we report that capsaicin has a cocarcinogenic effect on 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis in vivo and is mediated through the epidermal growth factor receptor (EGFR), but not the transient receptor potential vanilloid subfamily member 1 (TRPV1).	Tetradecanoylphorbol Acetate	100-103	epidermal growth factor receptor	Mus musculus	170-202
10344756-5	1999	On the other hand, TPA-induced mitogen-activated protein kinase kinase 1/2 (MEK1/2)-extracellular signal-regulated kinase (ERK) activation was equally induced between HCT116 and the Ki-ras-disrupted clones.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase kinase 1	Homo sapiens	31-74
20660715-3	2010	Here, we report that capsaicin has a cocarcinogenic effect on 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis in vivo and is mediated through the epidermal growth factor receptor (EGFR), but not the transient receptor potential vanilloid subfamily member 1 (TRPV1).	Tetradecanoylphorbol Acetate	100-103	epidermal growth factor receptor	Mus musculus	204-208
10344756-5	1999	On the other hand, TPA-induced mitogen-activated protein kinase kinase 1/2 (MEK1/2)-extracellular signal-regulated kinase (ERK) activation was equally induced between HCT116 and the Ki-ras-disrupted clones.	Tetradecanoylphorbol Acetate	19-22	mitogen-activated protein kinase kinase 1	Homo sapiens	76-82
10344756-7	1999	The TPA-induced SEK1-JNK activation in these disrupted clones was completely inhibited by the protein kinase C (PKC) inhibitor, GF109203X (1 microM), but not by another PKC inhibitor, H7 (50 microM), whereas TPA-induced MEK1/2-ERK activation was partially and completely inhibited by GF109203X (1 microM) and H7 (50 microM), respectively.	Tetradecanoylphorbol Acetate	4-7	mitogen-activated protein kinase kinase 1	Homo sapiens	220-226
9564040-6	1998	PKC depletion by chronic TPA exposure abolished TPA-dependent ERK activation but failed to diminish the effect of Ang II.	Tetradecanoylphorbol Acetate	25-28	EPH receptor B2	Homo sapiens	62-65
9564040-6	1998	PKC depletion by chronic TPA exposure abolished TPA-dependent ERK activation but failed to diminish the effect of Ang II.	Tetradecanoylphorbol Acetate	48-51	EPH receptor B2	Homo sapiens	62-65
20660715-6	2010	Inhibitors of EGFR/MEK signaling suppressed TPA/capsaicin-induced COX-2 expression in TRPV1/KO cells, indicating that activation of EGFR and its downstream signaling is involved in COX-2 elevation.	Tetradecanoylphorbol Acetate	44-47	epidermal growth factor receptor	Mus musculus	14-18
20660715-6	2010	Inhibitors of EGFR/MEK signaling suppressed TPA/capsaicin-induced COX-2 expression in TRPV1/KO cells, indicating that activation of EGFR and its downstream signaling is involved in COX-2 elevation.	Tetradecanoylphorbol Acetate	44-47	epidermal growth factor receptor	Mus musculus	132-136
20471972-9	2010	1-100 pmol/ml PMA and 0.01-1 ng/ml IL-1beta significantly (p&lt;0.05) stimulated the production of MMP-1 by PDLC at both the transcriptional and the translational level.	Tetradecanoylphorbol Acetate	14-17	matrix metallopeptidase 1	Homo sapiens	99-104
9576485-5	1998	These effects were blocked by phorbol 12-myristate 13-acetate (PMA) and were dependent on the presence of a functional TCR/CD3 surface complex, no effects being recorded on mutant Jurkat cells lacking part of the CD3 structures.	Tetradecanoylphorbol Acetate	30-61	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	119-122
9576485-5	1998	These effects were blocked by phorbol 12-myristate 13-acetate (PMA) and were dependent on the presence of a functional TCR/CD3 surface complex, no effects being recorded on mutant Jurkat cells lacking part of the CD3 structures.	Tetradecanoylphorbol Acetate	63-66	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	119-122
9548562-0	1998	Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C. The phorbol ester, tetradecanoyl-phorbol 13-acetate (TPA), stimulates rapid proteolytic processing of the transmembrane, pro- form of heparin-binding epidermal growth factor-like growth factor (HB-EGF) at cell surfaces, suggesting the involvement of protein kinase C (PKC) isoforms in the HB-EGF secretion mechanism.	Tetradecanoylphorbol Acetate	211-214	heparin binding EGF like growth factor	Homo sapiens	84-122
9548562-5	1998	As expected, rapid secretion of HB-EGF-AP was induced in a time- and dose-dependent manner by TPA.	Tetradecanoylphorbol Acetate	94-97	heparin binding EGF like growth factor	Homo sapiens	32-38
9548562-10	1998	Ionomycin- and TPA-induced HB-EGF-AP secretion was not dependent on the presence of the proHB-EGF cytoplasmic domain and was specifically inhibited by the metalloproteinase inhibitors 1,10-phenanthroline and tissue inhibitor of metalloproteinase-1 (TIMP-1).	Tetradecanoylphorbol Acetate	15-18	heparin binding EGF like growth factor	Homo sapiens	27-33
20566751-8	2010	By GeneChip analysis, up-regulation of the transcription factor ELF3 was observed in both fetal bovine serum- and TPA-treated cells.	Tetradecanoylphorbol Acetate	114-117	E74 like ETS transcription factor 3	Homo sapiens	64-68
9652727-4	1998	TPA treatment arrested the cell cycle of a human hematopoietic cell line, MEG-01s, at the G1-S boundary and induced expression of p21/SDI1/WAF1/CIP1 and p27/KIP1.	Tetradecanoylphorbol Acetate	0-3	interferon alpha inducible protein 27	Homo sapiens	153-156
9652727-4	1998	TPA treatment arrested the cell cycle of a human hematopoietic cell line, MEG-01s, at the G1-S boundary and induced expression of p21/SDI1/WAF1/CIP1 and p27/KIP1.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1B	Homo sapiens	157-161
20566751-9	2010	Treatment with small interfering RNAs of ELF3 prevented up-regulation of claudin-7 by TPA.	Tetradecanoylphorbol Acetate	86-89	E74 like ETS transcription factor 3	Homo sapiens	41-45
9582014-0	1998	In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter.	Tetradecanoylphorbol Acetate	58-61	tyrosinase	Mus musculus	151-161
20584749-10	2010	In conclusion, our results show that direct modification of IKKbeta by PIC, presumably at the cysteine 179 residue, blocks NF-kappaB activation signaling and COX-2 induction in TPA-treated MCF-10A cells and also migration and transformation of these cells.	Tetradecanoylphorbol Acetate	177-180	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	60-67
9582014-4	1998	Further, the inhibition of melanogenesis by TPA results from a decrease of the tyrosinase promoter transcriptional activity and this effect is mimicked by over-expression of a constitutively active form of PKC alpha.	Tetradecanoylphorbol Acetate	44-47	tyrosinase	Mus musculus	79-89
9582014-6	1998	Additional experiments were undertaken to elucidate the mechanism by which TPA inhibits the tyrosinase gene transcription.	Tetradecanoylphorbol Acetate	75-78	tyrosinase	Mus musculus	92-102
9582014-7	1998	Deletions and mutation in the tyrosinase promoter showed that TPA acts on a M-box which is involved in tissue-specific expression and regulation by cAMP of the tyrosinase gene.	Tetradecanoylphorbol Acetate	62-65	tyrosinase	Mus musculus	30-40
9582014-7	1998	Deletions and mutation in the tyrosinase promoter showed that TPA acts on a M-box which is involved in tissue-specific expression and regulation by cAMP of the tyrosinase gene.	Tetradecanoylphorbol Acetate	62-65	tyrosinase	Mus musculus	160-170
9582014-9	1998	Since microphthalmia, strongly stimulates the transcriptional activity of the promoter we propose that TPA, through PKC activation, decreases microphthalmia binding to the M-box of the tyrosinase promoter, thereby leading to a reduced tyrosinase expression and melanogenesis inhibition.	Tetradecanoylphorbol Acetate	103-106	tyrosinase	Mus musculus	185-195
9582014-9	1998	Since microphthalmia, strongly stimulates the transcriptional activity of the promoter we propose that TPA, through PKC activation, decreases microphthalmia binding to the M-box of the tyrosinase promoter, thereby leading to a reduced tyrosinase expression and melanogenesis inhibition.	Tetradecanoylphorbol Acetate	103-106	tyrosinase	Mus musculus	235-245
10318836-9	1999	PMA-induced disruption of the CD4-Lck complex was rapid (within 5 min), and this disruption occurred within LDTI microdomains.	Tetradecanoylphorbol Acetate	0-3	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	34-37
20609221-5	2010	RESULTS: In this paper, we for the first time report that TSA suppresses PMA-induced OPN gene expression in human cervical carcinoma cells and previously unidentified AP-1 transcription factor is involved in this event.	Tetradecanoylphorbol Acetate	73-76	secreted phosphoprotein 1	Homo sapiens	85-88
10330231-4	1999	Acute exposure to the PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated HO-1 mRNA.	Tetradecanoylphorbol Acetate	36-67	heme oxygenase 1	Homo sapiens	85-89
10330231-4	1999	Acute exposure to the PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated HO-1 mRNA.	Tetradecanoylphorbol Acetate	69-72	heme oxygenase 1	Homo sapiens	85-89
9745617-8	1998	Western immunoblot analysis of cyclins (A, B1, D1 and E) and p27Kip1, a cyclin-dependent kinase inhibitor, indicated that TPA induced cyclin A and cyclin B1 expression in P+ (but not in P-) JB6 cells and this induction coincided in time with TPA-induced synthesis of DNA.	Tetradecanoylphorbol Acetate	122-125	cyclin B1	Homo sapiens	147-156
9745617-9	1998	TPA also strongly induced cyclin D1 expression in P+ (but not in P-) JB6 cells, but this induction started prior to the expression of cyclin A and cyclin B1.	Tetradecanoylphorbol Acetate	0-3	cyclin B1	Homo sapiens	147-156
20002174-0	2010	Overexpression of connexin26 in the basal keratinocytes reduces sensitivity to tumor promoter TPA.	Tetradecanoylphorbol Acetate	94-97	gap junction protein, beta 2	Mus musculus	18-28
9579392-5	1998	The efficacy of UTI as an inhibitor was dependent on the nature of the stimulus, because histamine release induced by PMA-mediated or calcium ionophore A23187-mediated processes was not inhibited by UTI.	Tetradecanoylphorbol Acetate	118-121	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	16-19
10385256-10	1999	Tranilast inhibited phorbol myristate acetate (PMA)-dependent stimulation of [3H]-thymidine incorporation and VEGF- and PMA-induced gene expression of integrin alpha v and c-fos in BREC.	Tetradecanoylphorbol Acetate	47-50	integrin subunit alpha V	Bos taurus	151-167
10385256-10	1999	Tranilast inhibited phorbol myristate acetate (PMA)-dependent stimulation of [3H]-thymidine incorporation and VEGF- and PMA-induced gene expression of integrin alpha v and c-fos in BREC.	Tetradecanoylphorbol Acetate	120-123	integrin subunit alpha V	Bos taurus	151-167
20002174-8	2010	Unexpectedly, the proliferative effect of tumor promoter TPA was strongly decreased in epidermis of K5.Cx26 transgenics.	Tetradecanoylphorbol Acetate	57-60	gap junction protein, beta 2	Mus musculus	103-107
9571981-3	1998	CSC-MS selectively suppressed interferon gamma (IFN gamma) induction of four macrophage functional capacities: enhanced phagocytosis of immunoglobulin-opsonized sheep red blood cells, TPA-induced H2O2 production, class II major histocompatibility complex expression, and nitric oxide synthesis.	Tetradecanoylphorbol Acetate	184-187	interferon gamma	Ovis aries	30-46
10331419-6	1999	Treatment of cells with phorbol 12-myristate 13-acetate, an activator of protein kinase C (PKC), reduced both insulin-stimulated PI 3-kinase activity by 57% and the association of IRS-2 to the p85 subunit of PI 3-kinase by 40%, whereas GF109203X, a specific inhibitor of PKC, partially prevented the inhibitory effect of ET-1 on insulin-induced PI 3-kinase activity.	Tetradecanoylphorbol Acetate	24-55	insulin receptor substrate 2	Homo sapiens	180-185
9571981-3	1998	CSC-MS selectively suppressed interferon gamma (IFN gamma) induction of four macrophage functional capacities: enhanced phagocytosis of immunoglobulin-opsonized sheep red blood cells, TPA-induced H2O2 production, class II major histocompatibility complex expression, and nitric oxide synthesis.	Tetradecanoylphorbol Acetate	184-187	interferon gamma	Ovis aries	48-57
9516439-11	1998	In contrast, the addition of recombinant Ral proteins (RalA and RalB), glucosylation substrates for TscL and TcdB-1470, but not for TcdB, to membranes of TcdB-1470- or TcsL-treated cells fully restored PLD stimulation by PMA without altering the strict MgATP dependence of PMA-induced PLD stimulation.	Tetradecanoylphorbol Acetate	221-224	RAS like proto-oncogene B	Homo sapiens	64-68
20002174-9	2010	This correlated with significant down-regulation of TPA-induced activity of protein kinase C (PKC) in K5.Cx26 mice.	Tetradecanoylphorbol Acetate	52-55	gap junction protein, beta 2	Mus musculus	105-109
20345709-10	2010	The P(2X1) antagonists Ro-0437626 or MRS-2159, or desensitization of P(2X1) receptors by prior treatment with alpha,beta-Methylene-ATP or omitting apyrase from the medium, reduced PMA-evoked Ca(2+)entry.	Tetradecanoylphorbol Acetate	180-183	purinergic receptor P2X 1	Homo sapiens	4-9
9514905-4	1998	The regulation of the c-myc mRNA by TPA correlated inversely with activation of cell death being down-regulated in LNCaP cells, and slightly increased in the androgen-independent cell lines.	Tetradecanoylphorbol Acetate	36-39	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	22-27
10217263-5	1999	LIF mRNA levels increased rapidly when the cells were treated with 8-(4-chlorophenylthio)adenosine 3",5"-cyclic monophosphate, phorbol 12-myristate 13-acetate (PMA), or A23187.	Tetradecanoylphorbol Acetate	127-158	LIF interleukin 6 family cytokine	Homo sapiens	0-3
10217263-5	1999	LIF mRNA levels increased rapidly when the cells were treated with 8-(4-chlorophenylthio)adenosine 3",5"-cyclic monophosphate, phorbol 12-myristate 13-acetate (PMA), or A23187.	Tetradecanoylphorbol Acetate	160-163	LIF interleukin 6 family cytokine	Homo sapiens	0-3
20345709-10	2010	The P(2X1) antagonists Ro-0437626 or MRS-2159, or desensitization of P(2X1) receptors by prior treatment with alpha,beta-Methylene-ATP or omitting apyrase from the medium, reduced PMA-evoked Ca(2+)entry.	Tetradecanoylphorbol Acetate	180-183	purinergic receptor P2X 1	Homo sapiens	69-74
10217263-7	1999	Inhibition of protein kinase C (PKC) by GF-1 09203X significantly reduced the PMA-induced LIF mRNA levels.	Tetradecanoylphorbol Acetate	78-81	LIF interleukin 6 family cytokine	Homo sapiens	90-93
10217263-10	1999	Moreover, inhibition of ERK kinase activity by PD98059 dramatically reduced PMA-stimulated phosphorylation of ERKs and induction of LIF mRNA.	Tetradecanoylphorbol Acetate	76-79	LIF interleukin 6 family cytokine	Homo sapiens	132-135
9530111-7	1998	Activation of p42mapk by PMA was significantly reduced by the PKC inhibitor Ro-31-8220 and completely inhibited by the protein tyrosine kinase inhibitor genistein.	Tetradecanoylphorbol Acetate	25-28	cyclin dependent kinase 20	Homo sapiens	14-17
20345481-5	2010	When U937 cells were treated with phorbol myristate acetate (PHA) or gamma-interferon, they significantly expressed both HO-1 and Bach1, like primary AML cells.	Tetradecanoylphorbol Acetate	34-59	heme oxygenase 1	Homo sapiens	121-125
9607141-5	1998	Furthermore, overexpression of a dominant negative PKC epsilon, but not dominant negative PKC alpha, blocks the synergistic effect of TPA and insulin-induced PI-3 kinase activity.	Tetradecanoylphorbol Acetate	134-137	protein kinase C epsilon	Homo sapiens	51-62
9607141-6	1998	These results indicate that the potentiation effect of TPA on insulin-induced PI-3 kinase activity is specific through PKC epsilon in JB6 cells.	Tetradecanoylphorbol Acetate	55-58	protein kinase C epsilon	Homo sapiens	119-130
10206975-5	1999	When the N-terminal region of Kir2.3 was replaced with that of Kir2.1, another member in the Kir2 family that is insensitive to PMA, the chimerical channel lost its PMA sensitivity.	Tetradecanoylphorbol Acetate	128-131	potassium inwardly rectifying channel subfamily J member 4 S homeolog	Xenopus laevis	30-36
20331435-4	2010	By using PMA and the phosphatase inhibitors cantharidin and calyculin A, we could selectively activate PKC or p38 MAPK respectively to promote TACE-dependent shedding of L-selectin.	Tetradecanoylphorbol Acetate	9-12	selectin L	Homo sapiens	170-180
10209306-0	1999	Continuous phosphorylation of GAP-43 and MARCKS by long-term TPA treatment in SK-N-SH human neuroblastoma cells.	Tetradecanoylphorbol Acetate	61-64	growth associated protein 43	Homo sapiens	30-36
10209306-1	1999	Long-term treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) down-regulates select protein kinase C (PKC) isozymes and may differentially affect PKC substrates.	Tetradecanoylphorbol Acetate	25-61	protein kinase C epsilon	Homo sapiens	108-111
10209306-1	1999	Long-term treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) down-regulates select protein kinase C (PKC) isozymes and may differentially affect PKC substrates.	Tetradecanoylphorbol Acetate	25-61	protein kinase C epsilon	Homo sapiens	152-155
10209306-1	1999	Long-term treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) down-regulates select protein kinase C (PKC) isozymes and may differentially affect PKC substrates.	Tetradecanoylphorbol Acetate	63-66	protein kinase C epsilon	Homo sapiens	108-111
10209306-1	1999	Long-term treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) down-regulates select protein kinase C (PKC) isozymes and may differentially affect PKC substrates.	Tetradecanoylphorbol Acetate	63-66	protein kinase C epsilon	Homo sapiens	152-155
9543636-5	1998	RESULTS: A phorbol mitogen (TPA), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B, stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression; TIMP-2 levels are reduced by TNF but not affected by the other treatments.	Tetradecanoylphorbol Acetate	28-31	matrix metallopeptidase 1	Homo sapiens	127-151
9496939-6	1998	Pretreatment of cells with phorbol 12-myristate 13-acetate, known to down-regulate protein kinase C expression, blocked EGF-induced cell migration.	Tetradecanoylphorbol Acetate	27-58	epidermal growth factor	Mus musculus	120-123
10209306-3	1999	Cells were treated with 70 nM TPA for 15 min, 17 or 72 h. Phosphorylation of MARCKS and GAP-43 was elevated throughout 72 h of TPA.	Tetradecanoylphorbol Acetate	30-33	growth associated protein 43	Homo sapiens	88-94
20444281-7	2010	When tested in prostate cancer cells, all compounds inhibited PMA-induced autophosphorylation of PKD1, with kb-NB142-70 being most active.	Tetradecanoylphorbol Acetate	62-65	polycystin 1, transient receptor potential channel interacting	Homo sapiens	97-101
10209306-3	1999	Cells were treated with 70 nM TPA for 15 min, 17 or 72 h. Phosphorylation of MARCKS and GAP-43 was elevated throughout 72 h of TPA.	Tetradecanoylphorbol Acetate	127-130	growth associated protein 43	Homo sapiens	88-94
10209306-4	1999	The magnitude and peptidic sites of phosphorylation in GAP-43 and MARCKS were similar after all TPA treatments.	Tetradecanoylphorbol Acetate	96-99	growth associated protein 43	Homo sapiens	55-61
10209306-5	1999	GAP-43, but not MARCKS, content was increased after 17 and 72 h of TPA.	Tetradecanoylphorbol Acetate	67-70	growth associated protein 43	Homo sapiens	0-6
10209306-7	1999	PKC epsilon and alpha isozyme content was greatly reduced after 72 h of TPA but membranes retained 23% of PKC activity.	Tetradecanoylphorbol Acetate	72-75	protein kinase C epsilon	Homo sapiens	0-11
10209306-7	1999	PKC epsilon and alpha isozyme content was greatly reduced after 72 h of TPA but membranes retained 23% of PKC activity.	Tetradecanoylphorbol Acetate	72-75	protein kinase C epsilon	Homo sapiens	0-3
10209306-8	1999	Only PKC epsilon translocated to membranes after 15 min TPA.	Tetradecanoylphorbol Acetate	56-59	protein kinase C epsilon	Homo sapiens	5-16
9531044-2	1998	Flow cytometric analysis clearly demonstrated that Bt2-cAMP and PMA both induced the cell surface expression of uPAR.	Tetradecanoylphorbol Acetate	64-67	plasminogen activator, urokinase receptor	Homo sapiens	112-116
9531044-3	1998	Northern analysis and nuclear run-on assay revealed that cAMP and PMA activated the uPAR gene transcription and both additively increased the uPAR mRNA level.	Tetradecanoylphorbol Acetate	66-69	plasminogen activator, urokinase receptor	Homo sapiens	84-88
9531044-3	1998	Northern analysis and nuclear run-on assay revealed that cAMP and PMA activated the uPAR gene transcription and both additively increased the uPAR mRNA level.	Tetradecanoylphorbol Acetate	66-69	plasminogen activator, urokinase receptor	Homo sapiens	142-146
9531044-5	1998	Furthermore, inhibition of the ongoing protein synthesis with cycloheximide abrogated completely the PMA-induced uPAR mRNA accumulation but only partially the induction by PMA plus cAMP, whereas the induction by cAMP alone was rather amplified, indicating that the de novo protein synthesis is necessary in the induction by PMA but not in the induction by cAMP and that the cAMP pathway may be dominant in uPAR gene expression in the PL-21 cells as compared to the PMA pathway.	Tetradecanoylphorbol Acetate	101-104	plasminogen activator, urokinase receptor	Homo sapiens	113-117
9531044-5	1998	Furthermore, inhibition of the ongoing protein synthesis with cycloheximide abrogated completely the PMA-induced uPAR mRNA accumulation but only partially the induction by PMA plus cAMP, whereas the induction by cAMP alone was rather amplified, indicating that the de novo protein synthesis is necessary in the induction by PMA but not in the induction by cAMP and that the cAMP pathway may be dominant in uPAR gene expression in the PL-21 cells as compared to the PMA pathway.	Tetradecanoylphorbol Acetate	101-104	plasminogen activator, urokinase receptor	Homo sapiens	406-410
10209306-9	1999	GAP-43 content after 72 h of TPA was increased in subcellular fractions in which significant PKC epsilon isozyme concentration remained.	Tetradecanoylphorbol Acetate	29-32	growth associated protein 43	Homo sapiens	0-6
10209306-10	1999	These results demonstrate that continuous TPA differentially affected phosphorylation of PKC substrate proteins and regulation of PKC isozyme content in SK-N-SH cells.	Tetradecanoylphorbol Acetate	42-45	protein kinase C epsilon	Homo sapiens	89-92
10209306-10	1999	These results demonstrate that continuous TPA differentially affected phosphorylation of PKC substrate proteins and regulation of PKC isozyme content in SK-N-SH cells.	Tetradecanoylphorbol Acetate	42-45	protein kinase C epsilon	Homo sapiens	130-133
9607724-6	1998	In agreement with previous observations on 21-hydroxylase mRNA and enzyme activity in primary cultures of human adrenocortical cells, the abundance of CYP21 transcripts was increased by cyclic AMP analogues (N6-monobutyryl cyclic AMP and 8-bromo cyclic AMP), insulin, IGF-I and tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	278-307	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	151-156
9607724-6	1998	In agreement with previous observations on 21-hydroxylase mRNA and enzyme activity in primary cultures of human adrenocortical cells, the abundance of CYP21 transcripts was increased by cyclic AMP analogues (N6-monobutyryl cyclic AMP and 8-bromo cyclic AMP), insulin, IGF-I and tetradecanoyl phorbol acetate (TPA).	Tetradecanoylphorbol Acetate	309-312	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	151-156
19618379-8	2010	RESULTS: In comparison with their counterparts without APOE4, patients with at least one copy of the APOE epsilon-4 allele showed higher spontaneous (p = 0.037) and PMA-induced (p = 0.039) production of IL-1beta after controlling for clinical variables.	Tetradecanoylphorbol Acetate	165-168	interleukin 1 alpha	Homo sapiens	203-211
20360975-6	2010	Phorbol myristate acetate (PMA) upregulated the expression of resistin mRNA in U937 cells by increasing the recruitment of Sp1, ATF-2 and PPARgamma on the resistin gene promoter.	Tetradecanoylphorbol Acetate	0-25	resistin	Homo sapiens	62-70
9442079-1	1998	The cell signaling docking protein p130cas became tyrosine-phosphorylated in SH-SY5Y human neuroblastoma cells during induced differentiation with 12-O-tetradecanoylphorbol-13-acetate (TPA) and serum or a combination of basic fibroblast growth factor (bFGF) and insulin-like growth factor-I (IGF-I).	Tetradecanoylphorbol Acetate	147-183	BCAR1 scaffold protein, Cas family member	Homo sapiens	35-42
9442079-1	1998	The cell signaling docking protein p130cas became tyrosine-phosphorylated in SH-SY5Y human neuroblastoma cells during induced differentiation with 12-O-tetradecanoylphorbol-13-acetate (TPA) and serum or a combination of basic fibroblast growth factor (bFGF) and insulin-like growth factor-I (IGF-I).	Tetradecanoylphorbol Acetate	185-188	BCAR1 scaffold protein, Cas family member	Homo sapiens	35-42
10233362-5	1999	Consistent with this observation, when THP-1 monocytic and HL-60 promyelocytic leukaemia cells expressing Ret were differentiated toward macrophages or granulocytes by treatment of 12-O-tetradecanoylphorbol-13-acetate (TPA) or all-trans retinoic acid (RA), Ret expression strikingly decreased during differentiation.	Tetradecanoylphorbol Acetate	181-217	ret proto-oncogene	Homo sapiens	106-109
10233362-5	1999	Consistent with this observation, when THP-1 monocytic and HL-60 promyelocytic leukaemia cells expressing Ret were differentiated toward macrophages or granulocytes by treatment of 12-O-tetradecanoylphorbol-13-acetate (TPA) or all-trans retinoic acid (RA), Ret expression strikingly decreased during differentiation.	Tetradecanoylphorbol Acetate	219-222	ret proto-oncogene	Homo sapiens	106-109
20360975-6	2010	Phorbol myristate acetate (PMA) upregulated the expression of resistin mRNA in U937 cells by increasing the recruitment of Sp1, ATF-2 and PPARgamma on the resistin gene promoter.	Tetradecanoylphorbol Acetate	0-25	resistin	Homo sapiens	155-163
10081608-8	1999	Site-specific phospho-tau immunoreactivity was increased in additive and synergistic manners by treatment of injected cells with TPA (which activates PKC), calcium ionophore (which activates calcium-dependent kinases), and wortmannin (which inhibits PIP3 kinase).	Tetradecanoylphorbol Acetate	129-132	microtubule associated protein tau	Homo sapiens	22-25
9781344-4	1998	The mouse lactoferrin gene responded to forskolin, cAMP, TPA and EGF stimulation via two adjacent enhancer elements, the CRE and EGFRE and collectively referred to as the Mitogen Response Unit (MRU).	Tetradecanoylphorbol Acetate	57-60	lactotransferrin	Mus musculus	10-21
10319992-0	1999	Overexpression of c-Myc inhibits p21WAF1/CIP1 expression and induces S-phase entry in 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive human cancer cells.	Tetradecanoylphorbol Acetate	86-122	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
20360975-6	2010	Phorbol myristate acetate (PMA) upregulated the expression of resistin mRNA in U937 cells by increasing the recruitment of Sp1, ATF-2 and PPARgamma on the resistin gene promoter.	Tetradecanoylphorbol Acetate	27-30	resistin	Homo sapiens	62-70
10319992-0	1999	Overexpression of c-Myc inhibits p21WAF1/CIP1 expression and induces S-phase entry in 12-O-tetradecanoylphorbol-13-acetate (TPA)-sensitive human cancer cells.	Tetradecanoylphorbol Acetate	124-127	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
9438385-0	1998	Taxol-induced p34cdc2 kinase activation and apoptosis inhibited by 12-O-tetradecanoylphorbol-13-acetate in human breast MCF-7 carcinoma cells.	Tetradecanoylphorbol Acetate	67-103	cyclin dependent kinase 1	Homo sapiens	14-21
10319992-5	1999	A time course after infection of TPA-arrested cells using a c-Myc-expressing adenovirus revealed that the inhibition of p21 expression preceded entry into S-phase.	Tetradecanoylphorbol Acetate	33-36	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	60-65
20360975-6	2010	Phorbol myristate acetate (PMA) upregulated the expression of resistin mRNA in U937 cells by increasing the recruitment of Sp1, ATF-2 and PPARgamma on the resistin gene promoter.	Tetradecanoylphorbol Acetate	27-30	resistin	Homo sapiens	155-163
20152816-5	2010	Treatment with 10nM phorbol myristate acetate (PMA) for 24h caused sustained increases in mRNA levels for various cardiomyogenic genes, such as Mef2C, cardiac actin and troponin, for at least 6 days following the drug removal.	Tetradecanoylphorbol Acetate	20-45	myocyte enhancer factor 2C	Homo sapiens	144-149
10362070-8	1999	The treatment of endothelial cells with phorbol-myristate-acetate (PMA) upregulated the expression of u-PA and u-PAR antigens.	Tetradecanoylphorbol Acetate	40-65	plasminogen activator, urokinase receptor	Homo sapiens	111-116
10362070-8	1999	The treatment of endothelial cells with phorbol-myristate-acetate (PMA) upregulated the expression of u-PA and u-PAR antigens.	Tetradecanoylphorbol Acetate	67-70	plasminogen activator, urokinase receptor	Homo sapiens	111-116
10381626-5	1999	Exposure of TPA-differentiated U937 cells to 0.8 microg/ml cycloheximide for 24 h, that triggers apoptosis in 50% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Bcl-xL expression without modifying Bcl-2, Mcl-1 and Bax protein levels.	Tetradecanoylphorbol Acetate	12-15	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	264-269
27416479-5	1998	When TPA/A23187 were added to the culture of bone marrow stromal cell line KM102, IL-11 transcripts were rapidly upregulated.	Tetradecanoylphorbol Acetate	5-8	interleukin 11	Homo sapiens	82-87
20152816-5	2010	Treatment with 10nM phorbol myristate acetate (PMA) for 24h caused sustained increases in mRNA levels for various cardiomyogenic genes, such as Mef2C, cardiac actin and troponin, for at least 6 days following the drug removal.	Tetradecanoylphorbol Acetate	47-50	myocyte enhancer factor 2C	Homo sapiens	144-149
9536123-8	1998	Both PKC depletion by treatment with phorbol 12-myristate 13-acetate (PMA) for 18 hr and PKC inhibition by Calphostin C rendered macrophages more permissive for the intracellular GBS survival.	Tetradecanoylphorbol Acetate	37-68	guanine nucleotide binding protein (G protein), beta 5	Mus musculus	179-182
20061381-1	2010	Plasminogen activator inhibitor type 1, (PAI-1) the primary inhibitor of the tissue-type (tPA) and urokinase-type (uPA) plasminogen activators, has been implicated in a wide range of pathological processes, making it an attractive target for pharmacologic inhibition.	Tetradecanoylphorbol Acetate	90-93	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	41-46
9536123-8	1998	Both PKC depletion by treatment with phorbol 12-myristate 13-acetate (PMA) for 18 hr and PKC inhibition by Calphostin C rendered macrophages more permissive for the intracellular GBS survival.	Tetradecanoylphorbol Acetate	70-73	guanine nucleotide binding protein (G protein), beta 5	Mus musculus	179-182
20179211-5	2010	DATS also diminished TPA-induced expression of c-Jun and c-Fos, the principal components of AP-1, and blunted the activation of c-Jun NH(2)-terminal kinase (JNK) and Akt.	Tetradecanoylphorbol Acetate	21-24	FBJ osteosarcoma oncogene	Mus musculus	57-62
10729774-5	1998	A role for matrix metalloproteinases in degradation was shown by: (1) stimulation by the phorbol ester TPA of PC3-induced matrix degradation and release of matrix metalloproteinase activity; (2) abrogation of matrix degradation by 1,10-phenanthroline, a metalloproteinase inhibitor, and (3) degradation of purified type I collagen by PC3 cells and their conditioned medium.	Tetradecanoylphorbol Acetate	103-106	proprotein convertase subtilisin/kexin type 1	Homo sapiens	110-113
10729774-5	1998	A role for matrix metalloproteinases in degradation was shown by: (1) stimulation by the phorbol ester TPA of PC3-induced matrix degradation and release of matrix metalloproteinase activity; (2) abrogation of matrix degradation by 1,10-phenanthroline, a metalloproteinase inhibitor, and (3) degradation of purified type I collagen by PC3 cells and their conditioned medium.	Tetradecanoylphorbol Acetate	103-106	proprotein convertase subtilisin/kexin type 1	Homo sapiens	334-337
10333308-7	1999	The four assessed IFNgamma-inducible functional capacities were: enhanced phagocytosis of immuoglobulin-opsonized sheep red blood cells, TPA-induced peroxide production, class II major histocompatibility complex expression, and nitric oxide synthesis with LPS co-stimulation.	Tetradecanoylphorbol Acetate	137-140	interferon gamma	Ovis aries	18-26
10066763-4	1999	It was found that the activation of short term (2-min) Na/Pi uptake by PMA is abolished when cells are infected with amphotropic murine retrovirus (binds Pit-2 receptor) but not with gibbon ape leukemia retrovirus (binds Pit-1 receptor), indicating that Pit-2 is the form of Na/Pi transporter/viral receptor regulated by PKC.	Tetradecanoylphorbol Acetate	71-74	solute carrier family 20, member 2	Mus musculus	154-159
20121949-4	2010	Using deletion mapping, the TPA-responsive element on the p15(INK4b) promoter was located between 77 and 228 bp upstream of the transcriptional initiation site, within which the putative binding regions of early growth response gene 1 (EGR-1) and stimulatory protein 1 (SP-1) were found.	Tetradecanoylphorbol Acetate	28-31	early growth response 1	Homo sapiens	236-241
10066763-4	1999	It was found that the activation of short term (2-min) Na/Pi uptake by PMA is abolished when cells are infected with amphotropic murine retrovirus (binds Pit-2 receptor) but not with gibbon ape leukemia retrovirus (binds Pit-1 receptor), indicating that Pit-2 is the form of Na/Pi transporter/viral receptor regulated by PKC.	Tetradecanoylphorbol Acetate	71-74	solute carrier family 20, member 2	Mus musculus	254-259
10049506-3	1999	Overexpression of holo PKC-epsilon inhibited the stimulatory effects of PMA (5-100 nM) on both PtdCho and PtdEtn hydrolysis.	Tetradecanoylphorbol Acetate	72-75	protein kinase C epsilon	Homo sapiens	23-34
9440083-1	1998	Natriuretic peptide C receptor (NPR-C) expression in rat mesangial cells is downregulated by platelet-derived growth factor (PDGF) and the protein kinase C agonist phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	164-189	natriuretic peptide receptor 3	Rattus norvegicus	0-30
10228559-3	1999	We therefore investigated the effect of the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on the expression of the ERCC-1 gene in A2780/CP70 human ovarian carcinoma cells.	Tetradecanoylphorbol Acetate	58-95	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	127-133
9440083-1	1998	Natriuretic peptide C receptor (NPR-C) expression in rat mesangial cells is downregulated by platelet-derived growth factor (PDGF) and the protein kinase C agonist phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	164-189	natriuretic peptide receptor 3	Rattus norvegicus	32-37
20121949-5	2010	Gene expression of EGR-1, Snail and SP-1 can be induced by TPA within 0.5-6 h. In addition, basal levels of SP-1, but not of the other two transcriptional factors, were observed.	Tetradecanoylphorbol Acetate	59-62	early growth response 1	Homo sapiens	19-24
9440083-1	1998	Natriuretic peptide C receptor (NPR-C) expression in rat mesangial cells is downregulated by platelet-derived growth factor (PDGF) and the protein kinase C agonist phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	191-194	natriuretic peptide receptor 3	Rattus norvegicus	0-30
10228559-3	1999	We therefore investigated the effect of the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on the expression of the ERCC-1 gene in A2780/CP70 human ovarian carcinoma cells.	Tetradecanoylphorbol Acetate	97-100	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	127-133
10228559-4	1999	TPA induced a four- to sixfold increase in steady-state ERCC-1 messenger RNA (mRNA) levels that was time- and concentration-dependent.	Tetradecanoylphorbol Acetate	0-3	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	56-62
9440083-1	1998	Natriuretic peptide C receptor (NPR-C) expression in rat mesangial cells is downregulated by platelet-derived growth factor (PDGF) and the protein kinase C agonist phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	191-194	natriuretic peptide receptor 3	Rattus norvegicus	32-37
20121949-6	2010	Blockade of TPA-induced gene expression of Snail, EGR-1 or SP-1 suppressed activation of the p15-pro228 reporter plasmid harboring the TPA-responsive element.	Tetradecanoylphorbol Acetate	12-15	early growth response 1	Homo sapiens	50-55
9440083-4	1998	NPR-C mRNA levels increased four- to eightfold within 6 h after treatment with the protein synthesis inhibitor cycloheximide, but simultaneous treatment with PMA or PDGF still decreased the level of NPR-C mRNA despite the presence of cycloheximide.	Tetradecanoylphorbol Acetate	158-161	natriuretic peptide receptor 3	Rattus norvegicus	199-204
10228559-5	1999	Nuclear run-on experiments demonstrated that the rate of transcription of ERCC-1 was approximately 2.8-fold higher in TPA-treated cells than in the controls.	Tetradecanoylphorbol Acetate	118-121	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	74-80
10228559-6	1999	TPA stimulation of A2780/CP70 cells also resulted in a rapid but transient induction of c-jun and c-fos as determined by Northern and Western blot analyses, which peaked about 2 h before the peak in ERCC-1 expression.	Tetradecanoylphorbol Acetate	0-3	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	199-205
10228559-11	1999	These data suggest that AP-1 may contribute to the upregulation of ERCC-1 in response to TPA in human ovarian cancer cells.	Tetradecanoylphorbol Acetate	89-92	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	67-73
9808423-0	1998	Transcriptional regulation of human transcription factor IIB in SMMC-7721 human hepatocellular carcinoma cells by all-trans-retinoic acid and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	142-173	cilia and flagella associated protein 20	Homo sapiens	36-60
20121949-6	2010	Blockade of TPA-induced gene expression of Snail, EGR-1 or SP-1 suppressed activation of the p15-pro228 reporter plasmid harboring the TPA-responsive element.	Tetradecanoylphorbol Acetate	135-138	early growth response 1	Homo sapiens	50-55
9808423-2	1998	Human transcription factor IIB (TFIIB) was discovered to be decreased on the 3rd day after the cells had been treated with retinoic acid and increased by phorbol 12-myristate 13-acetate, which stimulated the proliferation of human hepatocellular carcinoma cells.	Tetradecanoylphorbol Acetate	154-185	cilia and flagella associated protein 20	Homo sapiens	6-30
9808423-2	1998	Human transcription factor IIB (TFIIB) was discovered to be decreased on the 3rd day after the cells had been treated with retinoic acid and increased by phorbol 12-myristate 13-acetate, which stimulated the proliferation of human hepatocellular carcinoma cells.	Tetradecanoylphorbol Acetate	154-185	cilia and flagella associated protein 20	Homo sapiens	32-37
20121949-7	2010	More detailed deletion mapping and site-directed mutagenesis further concluded that the overlapping EGR-1/SP-1-binding site was required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	141-144	early growth response 1	Homo sapiens	100-105
20121949-8	2010	In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1.	Tetradecanoylphorbol Acetate	50-53	early growth response 1	Homo sapiens	98-103
20121949-8	2010	In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1.	Tetradecanoylphorbol Acetate	50-53	early growth response 1	Homo sapiens	219-224
9857376-9	1998	The tPA antigen elevation was confirmed by fibrin zymography showing an increase of tPA/PAI1 complexes.	Tetradecanoylphorbol Acetate	4-7	serpin family E member 1	Homo sapiens	88-92
9857376-9	1998	The tPA antigen elevation was confirmed by fibrin zymography showing an increase of tPA/PAI1 complexes.	Tetradecanoylphorbol Acetate	84-87	serpin family E member 1	Homo sapiens	88-92
20121949-8	2010	In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1.	Tetradecanoylphorbol Acetate	182-185	early growth response 1	Homo sapiens	98-103
10022904-8	1999	We also show that cell stimulation with phorbol 12-myristate 13-acetate activates IKKbeta, which is entirely dependent on the activity of alphaPKC but not that of the atypical isoforms.	Tetradecanoylphorbol Acetate	40-71	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	82-89
20121949-8	2010	In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1.	Tetradecanoylphorbol Acetate	182-185	early growth response 1	Homo sapiens	219-224
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	125-128	early growth response 1	Homo sapiens	72-77
10023015-8	1999	Especially in kidney cell lines, the levels of granulocyte-macrophage-CSF (GM-CSF), M-CSF and IL-6 were further strongly increased by the TPA and IL-1 pretreatment.	Tetradecanoylphorbol Acetate	138-141	colony stimulating factor 2	Homo sapiens	47-73
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	169-172	early growth response 1	Homo sapiens	72-77
10023015-8	1999	Especially in kidney cell lines, the levels of granulocyte-macrophage-CSF (GM-CSF), M-CSF and IL-6 were further strongly increased by the TPA and IL-1 pretreatment.	Tetradecanoylphorbol Acetate	138-141	colony stimulating factor 2	Homo sapiens	75-81
20121949-9	2010	Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation.	Tetradecanoylphorbol Acetate	169-172	early growth response 1	Homo sapiens	72-77
10023015-8	1999	Especially in kidney cell lines, the levels of granulocyte-macrophage-CSF (GM-CSF), M-CSF and IL-6 were further strongly increased by the TPA and IL-1 pretreatment.	Tetradecanoylphorbol Acetate	138-141	colony stimulating factor 1	Homo sapiens	76-81
20121949-10	2010	In conclusion, Snail associates with EGR-1 and SP-1 to mediate TPA-induced transcriptional upregulation of p15(INK4b) in HepG2.	Tetradecanoylphorbol Acetate	63-66	early growth response 1	Homo sapiens	37-42
20179161-7	2010	Furthermore, PD98059, a specific inhibitor of MEK1/2, and Juglone, a potent Pin1 inhibitor, markedly suppressed the expression of activator protein-2alpha and the HER-2 promoter activity induced by EGF or 12-O-tetradecanoylphorbol-13-acetate in MCF-7 cells.	Tetradecanoylphorbol Acetate	205-241	mitogen-activated protein kinase kinase 1	Homo sapiens	46-52
10049831-1	1999	Smubp-2 is a novel transcription factor that was first identified through its interaction with the immunoglobulin Smu region (Mizuta et al., 1993) and has been cloned by virtue of its binding to two 12-O-tetradecanoylphorbol-13-acetate-responsive elements in the Epstein-Barr virus immediate-early BZLF1 promoter (Gulley et al., 1997).	Tetradecanoylphorbol Acetate	199-235	immunoglobulin mu DNA binding protein 2	Homo sapiens	0-7
10049831-1	1999	Smubp-2 is a novel transcription factor that was first identified through its interaction with the immunoglobulin Smu region (Mizuta et al., 1993) and has been cloned by virtue of its binding to two 12-O-tetradecanoylphorbol-13-acetate-responsive elements in the Epstein-Barr virus immediate-early BZLF1 promoter (Gulley et al., 1997).	Tetradecanoylphorbol Acetate	199-235	protein Zta	Human gammaherpesvirus 4	298-303
10049831-4	1999	A 14-bp region that partially overlaps with a 12-O-tetradecanoylphorbol-13-acetate-responsive element was required for maximal repression by Smubp-2, but some repression was also seen with a minimal promoter containing only the BZLF1 promoter TATA box and an initiation site.	Tetradecanoylphorbol Acetate	46-82	immunoglobulin mu DNA binding protein 2	Homo sapiens	141-148
20179161-7	2010	Furthermore, PD98059, a specific inhibitor of MEK1/2, and Juglone, a potent Pin1 inhibitor, markedly suppressed the expression of activator protein-2alpha and the HER-2 promoter activity induced by EGF or 12-O-tetradecanoylphorbol-13-acetate in MCF-7 cells.	Tetradecanoylphorbol Acetate	205-241	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	76-80
10049831-4	1999	A 14-bp region that partially overlaps with a 12-O-tetradecanoylphorbol-13-acetate-responsive element was required for maximal repression by Smubp-2, but some repression was also seen with a minimal promoter containing only the BZLF1 promoter TATA box and an initiation site.	Tetradecanoylphorbol Acetate	46-82	protein Zta	Human gammaherpesvirus 4	228-233
19914200-5	2010	Together the evidence indicates that the COOH-terminal region of SphK1 encompasses a structural element that is necessary for the increase in catalytic activity in response to PMA treatment and that its deletion renders SphK1 constitutively active with respect to PMA treatment.	Tetradecanoylphorbol Acetate	264-267	sphingosine kinase 1	Homo sapiens	65-70
19880327-5	2010	Indeed, lipopolysaccharide (LPS)- or phorbol myristate acetate (PMA)-induced proinflammatory cytokine production was significantly inhibited in shRNA/IL-32 stable clones as compared to control clones.	Tetradecanoylphorbol Acetate	37-62	interleukin 32	Homo sapiens	150-155
9920928-2	1999	The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation.	Tetradecanoylphorbol Acetate	67-98	selectin E	Homo sapiens	151-161
9920928-2	1999	The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation.	Tetradecanoylphorbol Acetate	100-103	selectin E	Homo sapiens	151-161
9920928-5	1999	Simultaneous treatment with IL-1beta and PMA synergistically induced E-selectin gene expression but not when TNFalpha was substituted for IL-1beta.	Tetradecanoylphorbol Acetate	41-44	selectin E	Homo sapiens	69-79
9891065-3	1999	The serum response element (SRE) in the c-fos promoter is necessary and sufficient for induction of transcription of c-fos by serum, growth factors, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	171-207	FBJ osteosarcoma oncogene	Mus musculus	40-45
9891065-3	1999	The serum response element (SRE) in the c-fos promoter is necessary and sufficient for induction of transcription of c-fos by serum, growth factors, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	171-207	FBJ osteosarcoma oncogene	Mus musculus	117-122
9891065-3	1999	The serum response element (SRE) in the c-fos promoter is necessary and sufficient for induction of transcription of c-fos by serum, growth factors, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	209-212	FBJ osteosarcoma oncogene	Mus musculus	40-45
9891065-3	1999	The serum response element (SRE) in the c-fos promoter is necessary and sufficient for induction of transcription of c-fos by serum, growth factors, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	209-212	FBJ osteosarcoma oncogene	Mus musculus	117-122
9891065-8	1999	TPA-induced activation of the SRE was partially inhibited by dominant negative c-Raf, ERK1, or ERK2, and constitutively active mutants of PKC-alpha and PKC-epsilon activated the transactivation domain of Elk-1.	Tetradecanoylphorbol Acetate	0-3	ELK1, member of ETS oncogene family	Mus musculus	204-209
9891065-10	1999	Furthermore, TPA treatment of serum-starved NIH 3T3 cells led to phosphorylation of SEK1, and constitutively active mutants of PKC-alpha and PKC-epsilon activated the transactivation domain of c-Jun, a major substrate of JNK.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase kinase 4	Mus musculus	84-88
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	interleukin 1 alpha	Homo sapiens	151-161
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	interleukin 1 alpha	Homo sapiens	230-240
9925799-3	1999	When supernatants of cells stimulated with phorbol 12-myristate 13-acetate in the presence of propanil were assessed by enzyme-linked immunosorbent assay, IL-2 levels were dose-dependently decreased by 20 and 50 microM of propanil but not at 10 microM.	Tetradecanoylphorbol Acetate	43-74	interleukin 2	Mus musculus	155-159
11089885-11	1999	The expression of heme oxygenase (HO-1), a stress-response protein, has been used to monitor effects of hyperthermia, 12-O-tetradecanoly phorbol 13-acetate (TPA) and 4-HNE.	Tetradecanoylphorbol Acetate	157-160	heme oxygenase 1	Homo sapiens	34-38
10578486-0	1999	Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in benzo[a]pyrene-initiated CD-1 mouse skin by baicalein.	Tetradecanoylphorbol Acetate	21-57	CD1 antigen complex	Mus musculus	109-113
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Tetradecanoylphorbol Acetate	89-92	C-C motif chemokine ligand 3	Homo sapiens	43-53
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Tetradecanoylphorbol Acetate	89-92	C-C motif chemokine ligand 2	Homo sapiens	55-60
10389198-3	1999	There is a highly statistically significant correlation between tPA/PAI-1 complex and both PAI-1 and tPA antigen.	Tetradecanoylphorbol Acetate	64-67	serpin family E member 1	Homo sapiens	68-73
10389198-3	1999	There is a highly statistically significant correlation between tPA/PAI-1 complex and both PAI-1 and tPA antigen.	Tetradecanoylphorbol Acetate	64-67	serpin family E member 1	Homo sapiens	91-112
9894157-6	1998	In contrast, the FEN-1 mRNA level showed a sharp decrease in HL-60 cells differentiated by dimethyl-sulfoxide, all-trans retinoic acid or 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	138-174	flap structure-specific endonuclease 1	Homo sapiens	17-22
9862370-3	1998	Addition of various co-stimuli (phorbol 12-myristate 13-acetate or monoclonal antibodies to CD3 or CD2) increases the CD82-induced morphological alterations and, reciprocally, CD82 engagement synergizes with these stimuli to induce T cell activation as indicated by both primary tyrosine phosphorylation and IL-2 production.	Tetradecanoylphorbol Acetate	32-63	CD2 molecule	Homo sapiens	99-102
9885438-5	1998	On the other hand, TNF selectively induced tyrosine phosphorylation of p42, and PMA selectively induced that of p44 and p42.	Tetradecanoylphorbol Acetate	80-83	cyclin dependent kinase 20	Homo sapiens	120-123
9819387-8	1998	The C1 domain could also confer phorbol myristate acetate-regulated transforming activity on a prenylation-defective mutant of K-Ras.	Tetradecanoylphorbol Acetate	32-57	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	127-132
9820166-6	1998	Moreover, stimulation of SW-480 cells by thrombin or PMA led to a significant increase in TF mRNA within 3 h as measured by the reverse-transcription PCR method, which was also dependent on the activation of PKC.	Tetradecanoylphorbol Acetate	53-56	coagulation factor III, tissue factor	Homo sapiens	90-92
9823934-5	1998	Although IL-2-stimulated or PMA-plus-ionomycin-stimulated PBLs were positive for both Fas and FasL, no significant increase in apoptosis was demonstrated in these activated PBLs.	Tetradecanoylphorbol Acetate	28-31	Fas ligand	Homo sapiens	94-98
9823934-7	1998	Only IL-2-stimulated or PMA-plus-ionomycin-stimulated PBLs killed Fas+ target cells efficiently via the interaction of Fas on target cells with FasL of PBLs.	Tetradecanoylphorbol Acetate	24-27	Fas ligand	Homo sapiens	144-148
9756922-3	1998	A low shear force cell adhesion assay showed that TPA treatment significantly inhibited E-selectin-mediated cell adhesion.	Tetradecanoylphorbol Acetate	50-53	selectin E	Homo sapiens	88-98
9770354-2	1998	Following incubation with 10 nM PMA (24 h), antisense-expressing cells displayed induction of p27(KIP1) but not of p21, whereas empty vector-containing cells (U937/pREP4) exhibited induction of both p21 and p27.	Tetradecanoylphorbol Acetate	32-35	cyclin dependent kinase inhibitor 1B	Homo sapiens	98-102
9733851-0	1998	Activation of the Epstein-Barr virus transcription factor BZLF1 by 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation.	Tetradecanoylphorbol Acetate	67-103	protein Zta	Human gammaherpesvirus 4	58-63
9733851-4	1998	We report here that the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is capable of inducing BZLF1"s activity even further.	Tetradecanoylphorbol Acetate	38-74	protein Zta	Human gammaherpesvirus 4	104-109
9733767-3	1998	This conclusion is further substantiated by the finding that expression of ESE-1, an Ets transcription factor involved in SPRR regulation, is also induced by TPA, with kinetics similar to SPRR1A.	Tetradecanoylphorbol Acetate	158-161	E74 like ETS transcription factor 3	Homo sapiens	75-80
9739170-5	1998	However, genistein did not alter the amylase release stimulated by TPA but inhibited TPA-stimulated p125FAK and paxillin tyrosine phosphorylation by 70%.	Tetradecanoylphorbol Acetate	85-88	protein tyrosine kinase 2	Rattus norvegicus	100-107
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Tetradecanoylphorbol Acetate	80-116	interleukin 1 alpha	Homo sapiens	175-179
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Tetradecanoylphorbol Acetate	80-116	interleukin 1 receptor antagonist	Homo sapiens	253-277
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Tetradecanoylphorbol Acetate	80-116	interleukin 1 receptor antagonist	Homo sapiens	279-285
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Tetradecanoylphorbol Acetate	80-116	interleukin 1 alpha	Homo sapiens	253-257
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Tetradecanoylphorbol Acetate	118-121	interleukin 1 alpha	Homo sapiens	175-179
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Tetradecanoylphorbol Acetate	118-121	interleukin 1 receptor antagonist	Homo sapiens	253-277
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Tetradecanoylphorbol Acetate	118-121	interleukin 1 receptor antagonist	Homo sapiens	279-285
9722543-3	1998	We demonstrate here that culture of human skin fibroblasts in RCG or in CD- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated monolayers resulted in the activation of an IL-1 autocrine feedback loop that was switched off by the naturally occurring IL-1 receptor antagonist (IL-1RA), a blocker of the common IL-1 receptor.	Tetradecanoylphorbol Acetate	118-121	interleukin 1 alpha	Homo sapiens	253-257
9722543-5	1998	The RCG- as well as the TPA-, IL-1-, and CD-induced up-regulation of both MMP-1 and IL-1 was totally suppressed by protein tyrosine kinases inhibitors.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 alpha	Homo sapiens	30-34
9722543-5	1998	The RCG- as well as the TPA-, IL-1-, and CD-induced up-regulation of both MMP-1 and IL-1 was totally suppressed by protein tyrosine kinases inhibitors.	Tetradecanoylphorbol Acetate	24-27	matrix metallopeptidase 1	Homo sapiens	74-79
9722543-5	1998	The RCG- as well as the TPA-, IL-1-, and CD-induced up-regulation of both MMP-1 and IL-1 was totally suppressed by protein tyrosine kinases inhibitors.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 alpha	Homo sapiens	84-88
9730868-5	1998	In contrast, C5a- and PMA-induced adhesion to TNF-alpha/IFN-gamma-activated NHBEC (increased from 11.1 +/- 1.3% to 21.9 +/- 1.0% and 27.6 +/- 1.9%, respectively) was CD18- and ICAM-1-dependent.	Tetradecanoylphorbol Acetate	22-25	lymphotoxin beta receptor	Homo sapiens	166-170
9743233-1	1998	Reactive oxygen species generated by treatment of smooth muscle cells (SMCs) with either phorbol 12-myristate 13-acetate or with the combination of H2O2 and vanadate strongly induce expression of the class A scavenger receptor (SR-A) gene.	Tetradecanoylphorbol Acetate	89-120	macrophage scavenger receptor 1	Homo sapiens	228-232
9768762-2	1998	In contrast, IL-4 and IL-5 production by mast cells stimulated in vitro with PMA, ionomycin, or IgE cross-linking are unaffected.	Tetradecanoylphorbol Acetate	77-80	interleukin 4	Mus musculus	13-17
9768762-2	1998	In contrast, IL-4 and IL-5 production by mast cells stimulated in vitro with PMA, ionomycin, or IgE cross-linking are unaffected.	Tetradecanoylphorbol Acetate	77-80	interleukin 5	Mus musculus	22-26
9706865-0	1998	12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	0-36	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	102-108
9706865-6	1998	In MCF-7 cells treated with TPA prior to treatment with TCDD, the AhR mRNA level was elevated, the ERalpha mRNA level remained suppressed, and the ratio of CYP1B1 to CYP1A1 mRNA was increased compared with treatment with TCDD alone.	Tetradecanoylphorbol Acetate	28-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	166-172
9717725-1	1998	Stimulation with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore ionomycin increased native low density lipoprotein (LDL) receptor gene expression in the human leukemic T cell line Jurkat when cells were cultured in the absence of sterols and also increased nuclear accumulation of sterol regulatory element binding protein (SREBP)-1.	Tetradecanoylphorbol Acetate	17-48	low density lipoprotein receptor	Homo sapiens	108-146
9717725-1	1998	Stimulation with phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore ionomycin increased native low density lipoprotein (LDL) receptor gene expression in the human leukemic T cell line Jurkat when cells were cultured in the absence of sterols and also increased nuclear accumulation of sterol regulatory element binding protein (SREBP)-1.	Tetradecanoylphorbol Acetate	50-53	low density lipoprotein receptor	Homo sapiens	108-146
9717725-2	1998	PMA and ionomycin likewise increased LDL receptor mRNA levels when cells were cultured in the presence of suppressive concentrations of sterols, when neither SREBP-1 nor SREBP-2 was detectable in the nucleus.	Tetradecanoylphorbol Acetate	0-3	low density lipoprotein receptor	Homo sapiens	37-49
9680096-2	1998	Progressive decreases in the steady-state levels of the mRNAs for thymidylate synthase, topoisomerase II, and hypoxanthine guanine phosphoribosyltransferase occurred following exposure to TPA or vitamin D3.	Tetradecanoylphorbol Acetate	188-191	thymidylate synthetase	Homo sapiens	66-86
9668112-1	1998	Biochemical characterization, regulation by phorbol 12-myristate 13-acetate and its possible involvement in nitrate reductase gene expression.	Tetradecanoylphorbol Acetate	44-75	nitrate reductase [NADH] 1	Zea mays	108-125
9688899-7	1998	Furthermore, stimulation of endothelial cells with histamine or phorbol myristate acetate (PMA) enhanced tyrosine phosphorylation of paxillin and pp125FAK, which was blocked by the tyrosine kinase inhibitor damnacanthal.	Tetradecanoylphorbol Acetate	64-89	paxillin	Homo sapiens	133-141
9688899-7	1998	Furthermore, stimulation of endothelial cells with histamine or phorbol myristate acetate (PMA) enhanced tyrosine phosphorylation of paxillin and pp125FAK, which was blocked by the tyrosine kinase inhibitor damnacanthal.	Tetradecanoylphorbol Acetate	91-94	paxillin	Homo sapiens	133-141
9678170-7	1998	Upon concurrent stimulation of EL4.IL-2 cells with phorbol 12-myristate-13-acetate, seven of the eight strains displayed significant enhancement of IL-2 and IL-5 production, with S. thermophilus being most effective.	Tetradecanoylphorbol Acetate	51-82	interleukin 2	Mus musculus	35-39
9678170-7	1998	Upon concurrent stimulation of EL4.IL-2 cells with phorbol 12-myristate-13-acetate, seven of the eight strains displayed significant enhancement of IL-2 and IL-5 production, with S. thermophilus being most effective.	Tetradecanoylphorbol Acetate	51-82	interleukin 2	Mus musculus	148-152
9678170-7	1998	Upon concurrent stimulation of EL4.IL-2 cells with phorbol 12-myristate-13-acetate, seven of the eight strains displayed significant enhancement of IL-2 and IL-5 production, with S. thermophilus being most effective.	Tetradecanoylphorbol Acetate	51-82	interleukin 5	Mus musculus	157-161
9658190-6	1998	Cotransfection of MAPK pathway dominant negative mutants (for Raf, MAPK, or CREB kinase) blocked nicotinic or PMA activation of chromogranin A, although a dominant negative Ras mutant was without effect.	Tetradecanoylphorbol Acetate	110-113	cAMP responsive element binding protein 1	Rattus norvegicus	76-80
9715516-9	1998	As in the TPA study, papillomas were induced in both male and female TGF alpha null mice.	Tetradecanoylphorbol Acetate	10-13	transforming growth factor alpha	Mus musculus	69-78
9405068-7	1997	TPA (1 microM) caused 45% and the calcium ionophore, A23187, 11% of maximal tyrosine phosphorylation of p125(FAK) seen with NMB.	Tetradecanoylphorbol Acetate	0-3	protein tyrosine kinase 2	Rattus norvegicus	109-112
9405068-7	1997	TPA (1 microM) caused 45% and the calcium ionophore, A23187, 11% of maximal tyrosine phosphorylation of p125(FAK) seen with NMB.	Tetradecanoylphorbol Acetate	0-3	neuromedin B	Rattus norvegicus	124-127
9405068-9	1997	Pretreatment with the selective PKC inhibitor, GF109203X, inhibited TPA-induced p125(FAK) tyrosine phosphorylation, but it had no effect on the NMB stimulation.	Tetradecanoylphorbol Acetate	68-71	protein tyrosine kinase 2	Rattus norvegicus	85-88
9405068-13	1997	Cytochalasin D, an agent which disrupts actin microfilaments, inhibited BN- and TPA-induced tyrosine phosphorylation of p125(FAK) completely.	Tetradecanoylphorbol Acetate	80-83	protein tyrosine kinase 2	Rattus norvegicus	125-128
9388272-5	1997	272, 31172-31181), we demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment of Fao cells induces tyrosine phosphorylation of several proteins including ErbB2 and ErbB3.	Tetradecanoylphorbol Acetate	40-71	erb-b2 receptor tyrosine kinase 3	Rattus norvegicus	174-179
9388272-5	1997	272, 31172-31181), we demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment of Fao cells induces tyrosine phosphorylation of several proteins including ErbB2 and ErbB3.	Tetradecanoylphorbol Acetate	73-76	erb-b2 receptor tyrosine kinase 3	Rattus norvegicus	174-179
9492192-0	1997	Cytokines and cross-linking of sIgM augment PMA-induced activation of human leukaemic CD5+ B cells.	Tetradecanoylphorbol Acetate	44-47	CD5 molecule	Homo sapiens	86-89
21528341-5	1997	More specifically, we observed: (a) increased secretion and/or activation of gelatinases A (MMP-2) and B (MMP-9) after exposure of 8 cell lines to 10(-6) M TPA; (b) increased activation of interstitial collagenase (MMP-1) caseinolysis after stimulation of 3 cancer cell lines with 10(-7) M TPA; and (c) increased activation of MMP-2 after exposure of 2 cell lines to 0.5 mM H3O2.	Tetradecanoylphorbol Acetate	156-159	matrix metallopeptidase 1	Homo sapiens	215-220
9375695-6	1997	In agreement with this observation, immunoprecipitation of VAChT from 32P-labeled synaptosomes showed that phosphorylation occurs and that incorporation of 32P in the VAChT protein increases in the presence of PMA.	Tetradecanoylphorbol Acetate	210-213	solute carrier family 18 member A3	Homo sapiens	59-64
9375695-6	1997	In agreement with this observation, immunoprecipitation of VAChT from 32P-labeled synaptosomes showed that phosphorylation occurs and that incorporation of 32P in the VAChT protein increases in the presence of PMA.	Tetradecanoylphorbol Acetate	210-213	solute carrier family 18 member A3	Homo sapiens	167-172
9345026-6	1997	Furthermore, the amount of p27(Kip1) protein associated with cyclin E/cdk2 greatly increases 24 to 72 hours after PMA treatment.	Tetradecanoylphorbol Acetate	114-117	interferon alpha inducible protein 27	Homo sapiens	27-30
9648724-7	1998	Inhibition of protein kinase C by either calphostin C or phorbol 12-myristate 13-acetate downregulation inhibited the Ang II-induced tyrosine phosphorylation of p130Cas.	Tetradecanoylphorbol Acetate	57-88	BCAR1 scaffold protein, Cas family member	Homo sapiens	161-168
9345026-6	1997	Furthermore, the amount of p27(Kip1) protein associated with cyclin E/cdk2 greatly increases 24 to 72 hours after PMA treatment.	Tetradecanoylphorbol Acetate	114-117	cyclin dependent kinase inhibitor 1B	Homo sapiens	31-35
19880327-5	2010	Indeed, lipopolysaccharide (LPS)- or phorbol myristate acetate (PMA)-induced proinflammatory cytokine production was significantly inhibited in shRNA/IL-32 stable clones as compared to control clones.	Tetradecanoylphorbol Acetate	64-67	interleukin 32	Homo sapiens	150-155
19956200-2	2010	Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation to an adherent monocytic phenotype.	Tetradecanoylphorbol Acetate	6-31	lysine methyltransferase 2A	Homo sapiens	118-121
9815584-5	1997	The anti-invasive effects of HMS-1, HMS-3, and HMS-4 can be enhanced by phorbol 12-myristate 13-acetate (down to 2% +/- 1% of control) by a maspin-dependent mechanism and abolished by dexamethasone (up to 95% +/- 5% of control) by a maspin-independent mechanism (P &lt; 0.01).	Tetradecanoylphorbol Acetate	72-103	serpin family B member 5	Homo sapiens	140-146
9815584-5	1997	The anti-invasive effects of HMS-1, HMS-3, and HMS-4 can be enhanced by phorbol 12-myristate 13-acetate (down to 2% +/- 1% of control) by a maspin-dependent mechanism and abolished by dexamethasone (up to 95% +/- 5% of control) by a maspin-independent mechanism (P &lt; 0.01).	Tetradecanoylphorbol Acetate	72-103	serpin family B member 5	Homo sapiens	233-239
9392422-1	1997	The signaling pathway involved in low density lipoprotein (LDL) receptor gene expression induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) was investigated in the human hepatoma HepG2 cell line.	Tetradecanoylphorbol Acetate	118-154	low density lipoprotein receptor	Homo sapiens	34-72
9624139-9	1998	Dog mastocytoma cells incubated with 12-O-tetradecanoylphorbol-13-acetate increase expression of MC-DPPI mRNA.	Tetradecanoylphorbol Acetate	37-73	dipeptidyl peptidase 1	Canis lupus familiaris	100-104
19956200-2	2010	Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation to an adherent monocytic phenotype.	Tetradecanoylphorbol Acetate	33-36	lysine methyltransferase 2A	Homo sapiens	118-121
9603968-8	1998	Increased EGR-1 synthesis was mimicked by phorbol myristate acetate, but not by forskolin, and receptor-stimulated EGR-1 synthesis was partially inhibited by phorbol myristate acetate down-regulation.	Tetradecanoylphorbol Acetate	42-67	early growth response 1	Homo sapiens	10-15
9603968-8	1998	Increased EGR-1 synthesis was mimicked by phorbol myristate acetate, but not by forskolin, and receptor-stimulated EGR-1 synthesis was partially inhibited by phorbol myristate acetate down-regulation.	Tetradecanoylphorbol Acetate	158-183	early growth response 1	Homo sapiens	115-120
9392422-1	1997	The signaling pathway involved in low density lipoprotein (LDL) receptor gene expression induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) was investigated in the human hepatoma HepG2 cell line.	Tetradecanoylphorbol Acetate	156-159	low density lipoprotein receptor	Homo sapiens	34-72
9392422-2	1997	Treatment of HepG2 cells with 100 nM TPA resulted in an approximately 20-fold increase in LDL receptor mRNA level, as determined by RT-PCR, which peaked at 2-4 h of treatment and subsequently declined.	Tetradecanoylphorbol Acetate	37-40	low density lipoprotein receptor	Homo sapiens	90-102
9392422-3	1997	The protein kinase C (PKC) inhibitors calphostin C and staurosporine prevented TPA-mediated LDL receptor mRNA induction.	Tetradecanoylphorbol Acetate	79-82	low density lipoprotein receptor	Homo sapiens	92-104
9392422-9	1997	Furthermore, pretreatment of cells with PD98059 inhibited TPA-induced LDL receptor mRNA induction.	Tetradecanoylphorbol Acetate	58-61	low density lipoprotein receptor	Homo sapiens	70-82
19864322-3	2010	We previously showed that activation of protein kinase C (PKC) by carbachol and phorbol 12-myristate 13-acetate (PMA) decreases NKCC1 surface expression in T84 cells.	Tetradecanoylphorbol Acetate	80-111	solute carrier family 12 member 2	Homo sapiens	128-133
9389316-8	1997	The effect on CD97 surface expression of the phorbol ester, phorbol 12-myristate 13-acetate (PMA), is different in PBL and Jurkat T cells.	Tetradecanoylphorbol Acetate	60-91	adhesion G protein-coupled receptor E5	Homo sapiens	14-18
9389316-8	1997	The effect on CD97 surface expression of the phorbol ester, phorbol 12-myristate 13-acetate (PMA), is different in PBL and Jurkat T cells.	Tetradecanoylphorbol Acetate	93-96	adhesion G protein-coupled receptor E5	Homo sapiens	14-18
9367827-1	1997	The human monocytic leukemic cell line, THP-1, which differentiates toward macrophages in response to phorbol 12-myristate 13-acetate (PMA) was investigated for its ability to produce granulocyte colony-stimulating factor (G-CSF).	Tetradecanoylphorbol Acetate	135-138	colony stimulating factor 3	Homo sapiens	184-221
9367827-2	1997	G-CSF protein was neither produced during PMA-induced differentiation nor in response to dexamethasone (Dex) alone.	Tetradecanoylphorbol Acetate	42-45	colony stimulating factor 3	Homo sapiens	0-5
9367827-3	1997	However, when combined, PMA and Dex synergistically stimulated THP-1 cells to produce G-CSF.	Tetradecanoylphorbol Acetate	24-27	colony stimulating factor 3	Homo sapiens	86-91
9367827-4	1997	The synergistic interaction between PMA and Dex on G-CSF production appeared to be mediated through the production of interleukin-1 (IL-1) since neutralization of IL-1 activity completely inhibited G-CSF production.	Tetradecanoylphorbol Acetate	36-39	colony stimulating factor 3	Homo sapiens	51-56
9367827-4	1997	The synergistic interaction between PMA and Dex on G-CSF production appeared to be mediated through the production of interleukin-1 (IL-1) since neutralization of IL-1 activity completely inhibited G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 alpha	Homo sapiens	118-131
9367827-4	1997	The synergistic interaction between PMA and Dex on G-CSF production appeared to be mediated through the production of interleukin-1 (IL-1) since neutralization of IL-1 activity completely inhibited G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 alpha	Homo sapiens	133-137
9367827-4	1997	The synergistic interaction between PMA and Dex on G-CSF production appeared to be mediated through the production of interleukin-1 (IL-1) since neutralization of IL-1 activity completely inhibited G-CSF production.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 alpha	Homo sapiens	163-167
9367827-4	1997	The synergistic interaction between PMA and Dex on G-CSF production appeared to be mediated through the production of interleukin-1 (IL-1) since neutralization of IL-1 activity completely inhibited G-CSF production.	Tetradecanoylphorbol Acetate	36-39	colony stimulating factor 3	Homo sapiens	198-203
9341140-4	1997	Reporter gene assays also demonstrated that gastrin and PMA stimulated Elk-1- and c-Myc-dependent transactivation, consistent with gastrin- and PMA-induced activation of ERKs.	Tetradecanoylphorbol Acetate	56-59	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	82-87
9341140-4	1997	Reporter gene assays also demonstrated that gastrin and PMA stimulated Elk-1- and c-Myc-dependent transactivation, consistent with gastrin- and PMA-induced activation of ERKs.	Tetradecanoylphorbol Acetate	56-59	gastrin	Homo sapiens	131-138
9341140-4	1997	Reporter gene assays also demonstrated that gastrin and PMA stimulated Elk-1- and c-Myc-dependent transactivation, consistent with gastrin- and PMA-induced activation of ERKs.	Tetradecanoylphorbol Acetate	144-147	gastrin	Homo sapiens	44-51
9341140-4	1997	Reporter gene assays also demonstrated that gastrin and PMA stimulated Elk-1- and c-Myc-dependent transactivation, consistent with gastrin- and PMA-induced activation of ERKs.	Tetradecanoylphorbol Acetate	144-147	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	82-87
9334193-5	1997	The NH2Cl-treated neutrophils showed a decrease in both PKC activity and PMA-induced phosphorylation of a 47-kDa protein, which corresponds to the cytosolic factor of NADPH oxidase, p47(phox).	Tetradecanoylphorbol Acetate	73-76	pleckstrin	Homo sapiens	182-185
9359417-11	1997	Cytochalasin D, but not colchicine, completely inhibited CCK-8- and PMA-induced p125(FAK) and paxillin phosphorylation.	Tetradecanoylphorbol Acetate	68-71	protein tyrosine kinase 2	Rattus norvegicus	80-89
9370364-3	1997	In this study, through two-dimensionnal electrophoresis and immunoprecipitation experiments, we show using dimethylsulfoxide-differentiated HL60 promyelocytes that p40phox is in a basal phosphorylated state in resting cells and undergoes further phosphorylation on multiple sites upon stimulation of the NADPH oxidase by either phorbol myristate acetate or by the formyl peptide fMet-Leu-Phe-Lys.	Tetradecanoylphorbol Acetate	328-353	neutrophil cytosolic factor 4	Homo sapiens	164-171
9344614-0	1997	1-(Carboxymethylthio)tetradecane attenuates PDGF- and TPA-induced c-fos mRNA expression and increases the formation of phosphatidylethanolamine with a shift from less to more polar molecular species in C3H/10T1/2 cells.	Tetradecanoylphorbol Acetate	54-57	FBJ osteosarcoma oncogene	Mus musculus	66-71
9312114-7	1997	The role of the extracellular signal-related kinase (ERK) signaling pathway in the HMGI-C induction was highlighted by the result that the MAP kinase kinase (MEK) inhibitor, PD 98059, blocked DeltaRaf-1:ER- and 12-O-tetradecanoylphorbol-13-acetate-stimulated HMGI-C induction.	Tetradecanoylphorbol Acetate	211-247	high mobility group AT-hook 2	Rattus norvegicus	83-89
9362261-3	1997	Constitutive and 12-O-tetradecanoyl phorbol 13-acetate (TPA)-inducible binding to a TPA-responsive element (TRE) was also enhanced in c-Ha-rasEJ VSMC.	Tetradecanoylphorbol Acetate	17-54	transcription factor like 5	Homo sapiens	134-138
9362261-3	1997	Constitutive and 12-O-tetradecanoyl phorbol 13-acetate (TPA)-inducible binding to a TPA-responsive element (TRE) was also enhanced in c-Ha-rasEJ VSMC.	Tetradecanoylphorbol Acetate	56-59	transcription factor like 5	Homo sapiens	134-138
9362261-3	1997	Constitutive and 12-O-tetradecanoyl phorbol 13-acetate (TPA)-inducible binding to a TPA-responsive element (TRE) was also enhanced in c-Ha-rasEJ VSMC.	Tetradecanoylphorbol Acetate	84-87	transcription factor like 5	Homo sapiens	134-138
9362261-10	1997	These data suggest that oncogenic c-Ha-rasEJ circumvents a requirement for a TPA-responsive PKC isoform(s) during mitogenic stimulation of VSMC.	Tetradecanoylphorbol Acetate	77-80	transcription factor like 5	Homo sapiens	34-38
9384256-2	1997	We tested the hypothesis that protein kinase C activated by tetradecanoyl phorbol acetate (TPA) regulates adenosine A2a receptor mRNA levels.	Tetradecanoylphorbol Acetate	60-89	adenosine A2a receptor	Homo sapiens	106-128
9384256-2	1997	We tested the hypothesis that protein kinase C activated by tetradecanoyl phorbol acetate (TPA) regulates adenosine A2a receptor mRNA levels.	Tetradecanoylphorbol Acetate	91-94	adenosine A2a receptor	Homo sapiens	106-128
9384256-5	1997	TPA increased adenosine A2a receptor mRNA in a dose- and time-dependent fashion.	Tetradecanoylphorbol Acetate	0-3	adenosine A2a receptor	Homo sapiens	14-36
9317111-3	1997	In these experiments using CD8+ alloreactive cell lines, we demonstrate that induction of FasL mRNA can occur in response to either PMA or ionomycin independently.	Tetradecanoylphorbol Acetate	132-135	Fas ligand	Homo sapiens	90-94
9274810-7	1997	In contrast, IL-5 levels were increased significantly in 7-day PP cell cultures obtained 2 h after VT exposure both with and without PMA + ION exposure but not in other cultures.	Tetradecanoylphorbol Acetate	133-138	interleukin 5	Mus musculus	13-17
9278434-3	1997	However, inducible overexpression and activation of the protein kinase Calpha isozyme or the addition of 12-O-tetradecanoylphorbol-13-acetate in the prostate epithelial cell line, LNCaP, resulted in apoptosis preceded by induction of p21 and dephosphorylation of the retinoblastoma protein.	Tetradecanoylphorbol Acetate	105-141	H3 histone pseudogene 16	Homo sapiens	234-237
9309155-5	1997	Furthermore, azatyrosine inhibited activation of the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element in response to stimulation by oncogenic c-ErbB-2.	Tetradecanoylphorbol Acetate	53-89	erb-b2 receptor tyrosine kinase 2	Mus musculus	153-161
9309155-5	1997	Furthermore, azatyrosine inhibited activation of the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element in response to stimulation by oncogenic c-ErbB-2.	Tetradecanoylphorbol Acetate	91-94	erb-b2 receptor tyrosine kinase 2	Mus musculus	153-161
9358005-5	1997	The activity of the LIF promoter was stimulated in HEC-1B cells by a combination of phorbol ester (TPA) and ionomycin, which we had previously found to strongly induce its activity in Jurkat T-lymphoma cells.	Tetradecanoylphorbol Acetate	99-102	LIF interleukin 6 family cytokine	Homo sapiens	20-23
9315102-6	1997	This induction was dependent upon the expression of c-Fos since AP-1 transcriptional activity was not increased in TPA-treated keratinocytes derived from c-fos null mice.	Tetradecanoylphorbol Acetate	115-118	FBJ osteosarcoma oncogene	Mus musculus	52-57
9315102-8	1997	c-Fos was expressed only in TPA treated keratinocytes, Fra-2 was expressed only in calcium-treated cells, and Fra-1 was expressed in both.	Tetradecanoylphorbol Acetate	28-31	FBJ osteosarcoma oncogene	Mus musculus	0-5
9315102-9	1997	Exogenous expression of Fra-2 repressed AP-1 transcriptional activity in TPA-treated keratinocytes, while c-Fos expression activated the AP-1 sequence in calcium-treated keratinocytes.	Tetradecanoylphorbol Acetate	73-76	fos-like antigen 2	Mus musculus	24-29
9242548-7	1997	After differentiation with phorbol-12-myristate-13-acetate (PMA), iNOS transfectants produced more tumor necrosis factor-alpha (TNF-alpha) (124.9 +/- 25.4 pg/5 x 10(5) cells per 24 hours) than did empty-vector transfected cells (21.9 +/- 1.9 pg/5 x 10(5) cells per 24 hours; P = .02).	Tetradecanoylphorbol Acetate	60-63	tumor necrosis factor	Felis catus	99-126
9242548-7	1997	After differentiation with phorbol-12-myristate-13-acetate (PMA), iNOS transfectants produced more tumor necrosis factor-alpha (TNF-alpha) (124.9 +/- 25.4 pg/5 x 10(5) cells per 24 hours) than did empty-vector transfected cells (21.9 +/- 1.9 pg/5 x 10(5) cells per 24 hours; P = .02).	Tetradecanoylphorbol Acetate	60-63	tumor necrosis factor	Felis catus	128-137
9276523-6	1997	After priming with phorbol myristate acetate (PMA) or tumour necrosis factor-alpha (TNF-alpha), an increased mean fluorescence intensity (MFI) was obtained on neutrophils stained with polyclonal anti-LF antibodies and with AGM 2.29.	Tetradecanoylphorbol Acetate	19-44	immunoglobulin lambda like polypeptide 1	Homo sapiens	223-228
9276523-6	1997	After priming with phorbol myristate acetate (PMA) or tumour necrosis factor-alpha (TNF-alpha), an increased mean fluorescence intensity (MFI) was obtained on neutrophils stained with polyclonal anti-LF antibodies and with AGM 2.29.	Tetradecanoylphorbol Acetate	46-49	immunoglobulin lambda like polypeptide 1	Homo sapiens	223-228
9293391-9	1997	TPA increased RNA expression of the TNF-alpha, IL-1 alpha, IL-1 beta, IL-8 and TGF-beta 1.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 alpha	Homo sapiens	47-57
9293391-12	1997	PTX and BC reduced TPA-induced IL-1 alpha and beta expression.	Tetradecanoylphorbol Acetate	19-22	interleukin 1 alpha	Homo sapiens	31-41
9252447-5	1997	The protein kinase C (PKC) activator (12-O-tetradecanoylphorbol 13-acetate), the calcium ionophore (ionomycin), and a derivative of adenosine 3",5"-cyclic monophosphate induced only a slight increase in p70s6k activity.	Tetradecanoylphorbol Acetate	38-74	ribosomal protein S6 kinase B1	Rattus norvegicus	203-209
9247590-3	1997	We report that the mutation of S126 in the CD3-gamma chain that is known to inhibit phorbol-12-myristate 13-acetate-induced TCR down-regulation does not affect down-regulation induced by a specific agonist.	Tetradecanoylphorbol Acetate	84-115	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	124-127
9609725-8	1998	Phorbol 12-myristate 13-acetate, lipopolysaccharide, transforming growth factor-beta, tumor necrosis factor-alpha, or cycloheximide induced uPAR and uPAR mRNA expression in cultured rabbit pleural mesothelial cells and lung fibroblasts and concurrently reduced the uPAR mRNA-uPAR mRNABP interaction.	Tetradecanoylphorbol Acetate	0-31	plasminogen activator, urokinase receptor	Homo sapiens	140-144
9609725-8	1998	Phorbol 12-myristate 13-acetate, lipopolysaccharide, transforming growth factor-beta, tumor necrosis factor-alpha, or cycloheximide induced uPAR and uPAR mRNA expression in cultured rabbit pleural mesothelial cells and lung fibroblasts and concurrently reduced the uPAR mRNA-uPAR mRNABP interaction.	Tetradecanoylphorbol Acetate	0-31	plasminogen activator, urokinase receptor	Homo sapiens	149-153
9609725-8	1998	Phorbol 12-myristate 13-acetate, lipopolysaccharide, transforming growth factor-beta, tumor necrosis factor-alpha, or cycloheximide induced uPAR and uPAR mRNA expression in cultured rabbit pleural mesothelial cells and lung fibroblasts and concurrently reduced the uPAR mRNA-uPAR mRNABP interaction.	Tetradecanoylphorbol Acetate	0-31	plasminogen activator, urokinase receptor	Homo sapiens	149-153
9609725-8	1998	Phorbol 12-myristate 13-acetate, lipopolysaccharide, transforming growth factor-beta, tumor necrosis factor-alpha, or cycloheximide induced uPAR and uPAR mRNA expression in cultured rabbit pleural mesothelial cells and lung fibroblasts and concurrently reduced the uPAR mRNA-uPAR mRNABP interaction.	Tetradecanoylphorbol Acetate	0-31	plasminogen activator, urokinase receptor	Homo sapiens	149-153
9623611-10	1998	Addition of phorbol myristate acetate, an agent known to antagonize FSH actions, blocks FSH regulation of both cell shape and AKAP 140 expression.	Tetradecanoylphorbol Acetate	12-37	A-kinase anchoring protein 11	Rattus norvegicus	126-130
9572476-7	1998	Western blot analysis (under nonreducing conditions) of the TPA-CM from R6-PKCepsilon 30 and R6-PKCepsilon 10 cells revealed the presence of the 25 kD active forms of TGFbeta2 and 3.	Tetradecanoylphorbol Acetate	60-63	transforming growth factor, beta 2	Rattus norvegicus	167-181
9626138-2	1998	After the addition of A23187 with PMA, a significant induction in TR expression was observed after 6 h, with maximal induction occurring by 24 h. The addition of 8-bromo-cAMP (10(-4) mol/L) or TSH (10 U/L) alone had no effect on TR expression, nor did these agents influence the induction of TR brought about by the addition of A23187 and PMA.	Tetradecanoylphorbol Acetate	34-37	peroxiredoxin 5	Homo sapiens	66-68
9626138-2	1998	After the addition of A23187 with PMA, a significant induction in TR expression was observed after 6 h, with maximal induction occurring by 24 h. The addition of 8-bromo-cAMP (10(-4) mol/L) or TSH (10 U/L) alone had no effect on TR expression, nor did these agents influence the induction of TR brought about by the addition of A23187 and PMA.	Tetradecanoylphorbol Acetate	34-37	peroxiredoxin 5	Homo sapiens	229-231
9626138-2	1998	After the addition of A23187 with PMA, a significant induction in TR expression was observed after 6 h, with maximal induction occurring by 24 h. The addition of 8-bromo-cAMP (10(-4) mol/L) or TSH (10 U/L) alone had no effect on TR expression, nor did these agents influence the induction of TR brought about by the addition of A23187 and PMA.	Tetradecanoylphorbol Acetate	34-37	peroxiredoxin 5	Homo sapiens	229-231
9655251-4	1998	A single topical treatment of either 12-O-tetradecanoylphorbol-13-acetate (TPA) or chrysarobin or a single full-thickness wound induced the expression of HB-EGF and AR in mRNA samples isolated from whole mouse skin.	Tetradecanoylphorbol Acetate	37-73	heparin-binding EGF-like growth factor	Mus musculus	154-160
9655251-4	1998	A single topical treatment of either 12-O-tetradecanoylphorbol-13-acetate (TPA) or chrysarobin or a single full-thickness wound induced the expression of HB-EGF and AR in mRNA samples isolated from whole mouse skin.	Tetradecanoylphorbol Acetate	75-78	heparin-binding EGF-like growth factor	Mus musculus	154-160
9615391-8	1998	In addition, bryostatin 1 was less effective than PMA in dephosphorylating pRb, modifying E2F complexes, and downregulating c-Myc.	Tetradecanoylphorbol Acetate	50-53	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	124-129
9615391-9	1998	Co-administration of bryostatin 1 with PMA antagonized the latter"s differentiation-inducing capacity and anti-proliferative effects, actions that were accompanied by a reduction in PMA-mediated p21CIP1/WAF1 induction, CDK2 inhibition, pRb dephosphorylation, and c-Myc downregulation.	Tetradecanoylphorbol Acetate	39-42	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	263-268
9572272-1	1998	Activated transcription of the human neuropeptide Y gene (NPY) was investigated in SH-SY5Y neuroblastoma cells at the onset of sympathetic neuronal differentiation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum or by nerve growth factor (NGF).	Tetradecanoylphorbol Acetate	175-211	neuropeptide Y	Homo sapiens	37-51
9572272-1	1998	Activated transcription of the human neuropeptide Y gene (NPY) was investigated in SH-SY5Y neuroblastoma cells at the onset of sympathetic neuronal differentiation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum or by nerve growth factor (NGF).	Tetradecanoylphorbol Acetate	175-211	neuropeptide Y	Homo sapiens	58-61
9572272-1	1998	Activated transcription of the human neuropeptide Y gene (NPY) was investigated in SH-SY5Y neuroblastoma cells at the onset of sympathetic neuronal differentiation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum or by nerve growth factor (NGF).	Tetradecanoylphorbol Acetate	213-216	neuropeptide Y	Homo sapiens	37-51
9572272-1	1998	Activated transcription of the human neuropeptide Y gene (NPY) was investigated in SH-SY5Y neuroblastoma cells at the onset of sympathetic neuronal differentiation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum or by nerve growth factor (NGF).	Tetradecanoylphorbol Acetate	213-216	neuropeptide Y	Homo sapiens	58-61
9572272-3	1998	TPA treatment in the presence of serum induced NPY transcription in both wild-type SH-SY5Y (SH-SY5Y/wt) and SH-SY5Y/trk cells.	Tetradecanoylphorbol Acetate	0-3	neuropeptide Y	Homo sapiens	47-50
9572272-5	1998	Suppression of TPA-induced NPY transcription was obtained by expression of a dominant negative Jun protein, selective protein kinase C inhibition, or introduction of a mutated TRE, whereas NGF-induced NPY transcription was inhibited to a lesser degree.	Tetradecanoylphorbol Acetate	15-18	neuropeptide Y	Homo sapiens	27-30
9618801-7	1998	Inhibition of PKC by H7 or staurosporin (PKC inhibitors) or down-regulation by long-term treatment with 12-O-tetradecanoylphorbol-13-acetate enchanced ER binding capacity in a dose-dependent manner.	Tetradecanoylphorbol Acetate	104-140	estrogen receptor 1 (alpha)	Mus musculus	151-153
9705076-9	1998	The phorbol myristate acetate (PMA), which mimics the induction of interstitial collagenase by serotonin, fails to affect the inhibition of alpha2M production.	Tetradecanoylphorbol Acetate	31-34	matrix metallopeptidase 1	Rattus norvegicus	67-91
9545257-7	1998	In contrast, monocyte adherence to tissue culture plastic-stimulated CADTK tyrosine phosphorylation, a process that was enhanced by thapsigargin, phorbol 12-myristate 13-acetate, and RANTES but that was completely blocked by preincubation with cytochalasin D.	Tetradecanoylphorbol Acetate	146-177	protein tyrosine kinase 2 beta	Homo sapiens	69-74
9563476-3	1998	E2F1 mRNA levels were undetectable within 8 h of exposure to the protein kinase C activator, 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	93-130	E2F transcription factor 1	Homo sapiens	0-4
9563476-3	1998	E2F1 mRNA levels were undetectable within 8 h of exposure to the protein kinase C activator, 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	132-135	E2F transcription factor 1	Homo sapiens	0-4
9563476-5	1998	In contrast, a growth inhibitor-resistant carcinoma cell line, SCC25, had a very stable E2F1 half-life that was only moderately reduced following TPA treatment.	Tetradecanoylphorbol Acetate	146-149	E2F transcription factor 1	Homo sapiens	88-92
9516131-4	1998	Treatment of EC with GAS6 significantly inhibited adhesion of polymorphonuclear cells (PMN) induced by phorbol 12-myristate 13-acetate (PMA), platelet-activating factor (PAF), thrombin, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), but not that induced by FMLP and IL-8.	Tetradecanoylphorbol Acetate	136-139	growth arrest specific 6	Homo sapiens	21-25
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	15-51	matrix metallopeptidase 1	Homo sapiens	110-115
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	15-51	serpin family E member 1	Homo sapiens	164-169
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	15-51	serpin family E member 1	Homo sapiens	217-222
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	53-56	matrix metallopeptidase 1	Homo sapiens	110-115
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	53-56	serpin family E member 1	Homo sapiens	164-169
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	53-56	serpin family E member 1	Homo sapiens	217-222
9568638-8	1998	The secretion of immunoreactive PAI-1 was considerably elevated (&gt; 20-fold) in TPA-treated MCF7/LCC1 cells, whereas the TPA-dependent level of 92-kDa MMP-9 was only approximately 2-fold higher in MCF7/LCC1 cells than in MCF-7 cells.	Tetradecanoylphorbol Acetate	82-85	serpin family E member 1	Homo sapiens	32-37
9568638-10	1998	These data suggest that TPA-responsive in vitro invasive properties that are probably associated with PAI-1 expression may co-vary with progression from hormone-dependent to -independent breast cancer.	Tetradecanoylphorbol Acetate	24-27	serpin family E member 1	Homo sapiens	102-107
9606549-0	1998	[Interleukin-2 and staurosporine abolish inhibition of splenocyte nonspecific cytotoxicity caused by high doses of phorbol myristate acetate in rats].	Tetradecanoylphorbol Acetate	115-140	interleukin 2	Rattus norvegicus	1-14
9651816-12	1998	These results indicate that the stimulation of Fas antigen or TNF receptor increases Mn-SOD activity of SVHK cells in the presence of IFN-gamma and that TPA augments the process through the activation of protein kinase C.	Tetradecanoylphorbol Acetate	153-156	Fas cell surface death receptor	Homo sapiens	47-58
9454755-10	1998	Induction of bomapin transcripts was not detected in the latter series of cell lines following a 24-hour treatment with phorbol myristate acetate (PMA, 10(-8) mol/L) or tumor necrosis factor-alpha (TNF-alpha, 30 U/mL), whereas treatment of THP-1 or AML-193 cells with these agents reduced the intensity of the bomapin PCR products.	Tetradecanoylphorbol Acetate	147-150	serpin family B member 10	Homo sapiens	13-20
9454755-13	1998	Bomapin antigen levels were correspondingly reduced after treatment with PMA.	Tetradecanoylphorbol Acetate	73-76	serpin family B member 10	Homo sapiens	0-7
9456311-6	1998	Photobleaching recovery studies showed that PMA nearly immobilized Cys1-GFP in the membrane, whereas DiC8 left Cys1-GFP diffusible within the membrane.	Tetradecanoylphorbol Acetate	44-47	cystin 1	Homo sapiens	67-71
9456311-9	1998	GFP-tagged Cys1Cys2-domains and full-length PKC-gamma also translocated from the cytosol to the plasma membrane in response to receptor or PMA stimuli, whereas significant plasma membrane translocation of Cys2-GFP was only observed in response to PMA addition.	Tetradecanoylphorbol Acetate	139-142	protein kinase C gamma	Homo sapiens	44-53
9458101-9	1998	Phorbol 12-myristate 13-acetate inhibited CD95-mediated apoptosis by counteracting the IFNgamma-, actinomycin D-, and cycloheximide-mediated but not the brefeldin A-mediated sensitization.	Tetradecanoylphorbol Acetate	0-31	Fas cell surface death receptor	Homo sapiens	42-46
9446602-4	1998	Here, we investigated the role of SPP and the protein kinase C activator, phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), in the caspase cascade leading to the proteolysis of poly(ADP-ribose) polymerase (PARP) and lamins.	Tetradecanoylphorbol Acetate	126-129	caspase 6	Homo sapiens	139-146
9446602-6	1998	Furthermore, both SPP and TPA inhibit the activation of caspase-6/Mch2 and subsequent lamin B cleavage.	Tetradecanoylphorbol Acetate	26-29	caspase 6	Homo sapiens	56-65
9446602-6	1998	Furthermore, both SPP and TPA inhibit the activation of caspase-6/Mch2 and subsequent lamin B cleavage.	Tetradecanoylphorbol Acetate	26-29	caspase 6	Homo sapiens	66-70
9427759-8	1998	This differential effect of D-type cyclins on v-Myb and c-Myb might help to explain the mechanism underlying the oncogenic activity of v-Myb, which appears to be a stronger transcriptional activator following the TPA-induced differentiation of transformed monoblasts when cyclin D1 and D2 are down-regulated.	Tetradecanoylphorbol Acetate	213-216	MYB proto-oncogene, transcription factor	Homo sapiens	48-51
9427759-8	1998	This differential effect of D-type cyclins on v-Myb and c-Myb might help to explain the mechanism underlying the oncogenic activity of v-Myb, which appears to be a stronger transcriptional activator following the TPA-induced differentiation of transformed monoblasts when cyclin D1 and D2 are down-regulated.	Tetradecanoylphorbol Acetate	213-216	MYB proto-oncogene, transcription factor	Homo sapiens	56-61
9427759-8	1998	This differential effect of D-type cyclins on v-Myb and c-Myb might help to explain the mechanism underlying the oncogenic activity of v-Myb, which appears to be a stronger transcriptional activator following the TPA-induced differentiation of transformed monoblasts when cyclin D1 and D2 are down-regulated.	Tetradecanoylphorbol Acetate	213-216	MYB proto-oncogene, transcription factor	Homo sapiens	46-51
9666308-2	1998	In fact, epidermal growth factor was an excellent mitogen, even after prolonged pretreatment of cells with TPA, suggesting that the PKC isoform implicated in proliferation is not down-regulated by 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	107-110	epidermal growth factor	Homo sapiens	9-32
9666308-2	1998	In fact, epidermal growth factor was an excellent mitogen, even after prolonged pretreatment of cells with TPA, suggesting that the PKC isoform implicated in proliferation is not down-regulated by 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	236-239	epidermal growth factor	Homo sapiens	9-32
9488117-8	1998	The present results suggest that the activation of TPA+-sensitive K+ channels contributes toward the relaxations mediated through beta- and beta2-adrenoceptor stimulation in rat mesenteric arteries.	Tetradecanoylphorbol Acetate	51-54	adrenoceptor beta 2	Rattus norvegicus	130-158
9870716-2	1998	In this work, we determined the effect of calphostin C on AR mRNA expression in IEC-6 cells, a rat intestinal epithelial cell line, and unexpectedly found that this compound enhanced the TPA-induced expression of AR mRNA.	Tetradecanoylphorbol Acetate	187-190	amphiregulin	Rattus norvegicus	58-60
9870716-2	1998	In this work, we determined the effect of calphostin C on AR mRNA expression in IEC-6 cells, a rat intestinal epithelial cell line, and unexpectedly found that this compound enhanced the TPA-induced expression of AR mRNA.	Tetradecanoylphorbol Acetate	187-190	amphiregulin	Rattus norvegicus	213-215
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Tetradecanoylphorbol Acetate	113-138	fibronectin 1	Mus musculus	186-188
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Tetradecanoylphorbol Acetate	113-138	fibronectin 1	Mus musculus	193-195
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Tetradecanoylphorbol Acetate	140-143	fibronectin 1	Mus musculus	186-188
19864322-3	2010	We previously showed that activation of protein kinase C (PKC) by carbachol and phorbol 12-myristate 13-acetate (PMA) decreases NKCC1 surface expression in T84 cells.	Tetradecanoylphorbol Acetate	113-116	solute carrier family 12 member 2	Homo sapiens	128-133
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Tetradecanoylphorbol Acetate	140-143	fibronectin 1	Mus musculus	193-195
19864322-12	2010	Together, these results strongly support the conclusion that PMA-stimulated NKCC1 endocytosis is associated with a clathrin pathway.	Tetradecanoylphorbol Acetate	61-64	solute carrier family 12 member 2	Homo sapiens	76-81
9848099-6	1998	Furthermore, zymographic analysis revealed that noncytotoxic concentrations (&lt; 10 microM) of TAC-101 inhibited TPA-induced production of urokinase-type plasminogen activator (u-PA) and matrix metalloproteinase (MMP)-9 from tumor cells, which is considered to be associated with their invasive and metastatic potentials.	Tetradecanoylphorbol Acetate	114-117	plasminogen activator, urokinase	Mus musculus	140-176
9848099-6	1998	Furthermore, zymographic analysis revealed that noncytotoxic concentrations (&lt; 10 microM) of TAC-101 inhibited TPA-induced production of urokinase-type plasminogen activator (u-PA) and matrix metalloproteinase (MMP)-9 from tumor cells, which is considered to be associated with their invasive and metastatic potentials.	Tetradecanoylphorbol Acetate	114-117	plasminogen activator, urokinase	Mus musculus	178-182
19766691-0	2010	Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity.	Tetradecanoylphorbol Acetate	18-43	C-C motif chemokine ligand 2	Homo sapiens	58-63
9645418-2	1998	When the peripheral mononuclear cells were stimulated with phorbol myristate acetate and ionomycin in the presence of monensin, which blocks the secretion of cytokines, the positive rates for the cytoplasmic IL-2 and IFN-gamma were lower and those for the cytoplasmic IL-4 and IL-10 were higher in SLE than in normal subjects.	Tetradecanoylphorbol Acetate	59-84	interleukin 2	Mus musculus	208-212
9645418-2	1998	When the peripheral mononuclear cells were stimulated with phorbol myristate acetate and ionomycin in the presence of monensin, which blocks the secretion of cytokines, the positive rates for the cytoplasmic IL-2 and IFN-gamma were lower and those for the cytoplasmic IL-4 and IL-10 were higher in SLE than in normal subjects.	Tetradecanoylphorbol Acetate	59-84	interleukin 4	Mus musculus	268-272
19766691-0	2010	Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity.	Tetradecanoylphorbol Acetate	45-48	C-C motif chemokine ligand 2	Homo sapiens	58-63
19766691-3	2010	We found that curcumin, a natural biologically active compound extracted from rhizomes of Curcuma species, significantly inhibited the PMA-induced increase in MCP-1 expression and secretion.	Tetradecanoylphorbol Acetate	135-138	C-C motif chemokine ligand 2	Homo sapiens	159-164
19895572-4	2010	The CD98-induced aggregation was enhanced by the general protein kinase inhibitors GF109203X and staurosporin, and by specific PKC-alpha/-beta peptide inhibitor 19-27, but inhibited by PKC activators such as phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	208-239	solute carrier family 3 member 2	Homo sapiens	4-8
19895572-4	2010	The CD98-induced aggregation was enhanced by the general protein kinase inhibitors GF109203X and staurosporin, and by specific PKC-alpha/-beta peptide inhibitor 19-27, but inhibited by PKC activators such as phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	241-244	solute carrier family 3 member 2	Homo sapiens	4-8
9395486-5	1997	Up-regulation of MMP-8 was observed after treatment of the cells with either tumor necrosis factor-alpha (10 ng/ml) or phorbol 12-myristate 13-acetate (10 nM).	Tetradecanoylphorbol Acetate	119-150	matrix metallopeptidase 8	Homo sapiens	17-22
19895572-7	2010	PMA-induced translocation of conventional PKC (cPKC) isozymes (alpha, beta and gamma), but decreased the expression of PKC-delta, which plays an important role in CD98-induced homotypic aggregation.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 3 member 2	Homo sapiens	163-167
9388261-8	1997	The binding of (p65)2 and/or c-Rel/p65 to the A2 probe was also detected from 12-o-tetradecanoylphorbol 13-acetate-stimulated HeLa, HOS, and A172 cells in which expression of MCP-1 mRNA was elevated.	Tetradecanoylphorbol Acetate	78-114	C-C motif chemokine ligand 2	Homo sapiens	175-180
19895572-8	2010	PMA treatment also suppressed the surface level of CD98 but not CD29, CD18 and CD147, dose- and time-dependently.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 3 member 2	Homo sapiens	51-55
19895572-8	2010	PMA treatment also suppressed the surface level of CD98 but not CD29, CD18 and CD147, dose- and time-dependently.	Tetradecanoylphorbol Acetate	0-3	basigin (Ok blood group)	Homo sapiens	79-84
9428734-3	1997	While cell surface L-selectin expression was abolished by phorbol 12-myristate 13-acetate (PMA), lymphocytes retained the ability to bind sulfatide in liquid phase as well as in immobilized solid phase.	Tetradecanoylphorbol Acetate	58-89	selectin L	Homo sapiens	19-29
19801682-2	2009	Here, we demonstrate that activation of the MAPK pathway with either epidermal growth factor or 12-O-tetradecanoylphorbol-13-acetate induces a G(2) phase delay independent of known G(2) phase checkpoint pathways but was specifically dependent on MAPK/extracellular signal-regulated kinase kinase (MEK1).	Tetradecanoylphorbol Acetate	96-132	mitogen-activated protein kinase kinase 1	Homo sapiens	297-301
9428734-3	1997	While cell surface L-selectin expression was abolished by phorbol 12-myristate 13-acetate (PMA), lymphocytes retained the ability to bind sulfatide in liquid phase as well as in immobilized solid phase.	Tetradecanoylphorbol Acetate	91-94	selectin L	Homo sapiens	19-29
9428739-1	1997	Natriuretic peptide receptor C (NPR-C) mRNA expression and ANP-binding activity via NPR-C are significantly down-regulated in HeLa cells with phorbol myristate acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	142-167	natriuretic peptide receptor 3	Homo sapiens	0-30
9428739-1	1997	Natriuretic peptide receptor C (NPR-C) mRNA expression and ANP-binding activity via NPR-C are significantly down-regulated in HeLa cells with phorbol myristate acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	142-167	natriuretic peptide receptor 3	Homo sapiens	32-37
9428739-1	1997	Natriuretic peptide receptor C (NPR-C) mRNA expression and ANP-binding activity via NPR-C are significantly down-regulated in HeLa cells with phorbol myristate acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	142-167	natriuretic peptide receptor 3	Homo sapiens	84-89
9428739-1	1997	Natriuretic peptide receptor C (NPR-C) mRNA expression and ANP-binding activity via NPR-C are significantly down-regulated in HeLa cells with phorbol myristate acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	169-172	natriuretic peptide receptor 3	Homo sapiens	0-30
9428739-1	1997	Natriuretic peptide receptor C (NPR-C) mRNA expression and ANP-binding activity via NPR-C are significantly down-regulated in HeLa cells with phorbol myristate acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	169-172	natriuretic peptide receptor 3	Homo sapiens	32-37
9428739-1	1997	Natriuretic peptide receptor C (NPR-C) mRNA expression and ANP-binding activity via NPR-C are significantly down-regulated in HeLa cells with phorbol myristate acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	169-172	natriuretic peptide receptor 3	Homo sapiens	84-89
9497498-3	1997	Murine mast cells were found to adhere to both mLN and hLN and to merosin, not only following exposure to phorbol 12-myristate 13-acetate (PMA), but also after Fc epsilon RI aggregation or addition of stem cell factor (SCF).	Tetradecanoylphorbol Acetate	106-137	glucosamine-6-phosphate deaminase 1	Homo sapiens	55-58
9497498-3	1997	Murine mast cells were found to adhere to both mLN and hLN and to merosin, not only following exposure to phorbol 12-myristate 13-acetate (PMA), but also after Fc epsilon RI aggregation or addition of stem cell factor (SCF).	Tetradecanoylphorbol Acetate	139-142	glucosamine-6-phosphate deaminase 1	Homo sapiens	55-58
9427323-1	1997	Activation of PKC with 12-tetra-decanoylphorbol-13-acetate (TPA) or inhibition with staurosporine or calphostin C down-regulated GnRH mRNA levels.	Tetradecanoylphorbol Acetate	60-63	gonadotropin releasing hormone 1	Mus musculus	129-133
9427323-3	1997	TPA transiently induced c-fos mRNA, whereas staurosporine or calphostin C failed to do so.	Tetradecanoylphorbol Acetate	0-3	FBJ osteosarcoma oncogene	Mus musculus	24-29
9427323-4	1997	However, PKC inhibitors blocked the TPA-evoked c-fos induction.	Tetradecanoylphorbol Acetate	36-39	FBJ osteosarcoma oncogene	Mus musculus	47-52
9427517-1	1997	Protein kinase C (PKC) activation after treatment of human neuroblastoma SK-N-BE(2)C cells with phorbol 12-myristate 13-acetate (PMA) was found to enhance transcription of the human dopamine beta-hydroxylase (DBH) in those cells.	Tetradecanoylphorbol Acetate	96-127	dopamine beta-hydroxylase	Homo sapiens	182-207
9427517-1	1997	Protein kinase C (PKC) activation after treatment of human neuroblastoma SK-N-BE(2)C cells with phorbol 12-myristate 13-acetate (PMA) was found to enhance transcription of the human dopamine beta-hydroxylase (DBH) in those cells.	Tetradecanoylphorbol Acetate	96-127	dopamine beta-hydroxylase	Homo sapiens	209-212
9427517-1	1997	Protein kinase C (PKC) activation after treatment of human neuroblastoma SK-N-BE(2)C cells with phorbol 12-myristate 13-acetate (PMA) was found to enhance transcription of the human dopamine beta-hydroxylase (DBH) in those cells.	Tetradecanoylphorbol Acetate	129-132	dopamine beta-hydroxylase	Homo sapiens	182-207
9427517-1	1997	Protein kinase C (PKC) activation after treatment of human neuroblastoma SK-N-BE(2)C cells with phorbol 12-myristate 13-acetate (PMA) was found to enhance transcription of the human dopamine beta-hydroxylase (DBH) in those cells.	Tetradecanoylphorbol Acetate	129-132	dopamine beta-hydroxylase	Homo sapiens	209-212
9395207-8	1997	Furthermore, zymographyic analysis showed that TPA treatment of BALB/3T3 cells induced secretion of gelatinase B and stromelysin-1 into the culture medium.	Tetradecanoylphorbol Acetate	47-50	matrix metallopeptidase 3	Mus musculus	117-130
9395207-10	1997	It seems likely that TPA-inducible MMPs are involved in carcinogenesis and TIMPs have a protective role against carcinogenesis in vivo.	Tetradecanoylphorbol Acetate	21-24	matrix metallopeptidase 3	Mus musculus	35-39
9348195-4	1997	Both 1,25-(OH)2D3 and TPA independently up-regulated the vitamin D receptor, p21, and the hypophosphorylated form of retinoblastoma (Rb) protein.	Tetradecanoylphorbol Acetate	22-25	H3 histone pseudogene 16	Homo sapiens	77-80
9348195-8	1997	In MCF-7D3Res cells, 1,25-(OH)2D3 treatment had minimal effects on p21 or Rb protein expression, whereas TPA down-regulated Rb protein and transiently up-regulated p21.	Tetradecanoylphorbol Acetate	105-108	H3 histone pseudogene 16	Homo sapiens	164-167
9348199-4	1997	We also found that treatment of L6 myotubes with 5 microM tetradecanoyl phorbol-13-acetate (TPA) for 24 h led to 80-100% losses of all DAG-dependent PKCs (alpha, beta1, beta2, delta, epsilon) and TPA-stimulated glucose transport (2-deoxyglucose uptake); in contrast, there was full retention of PKC-zeta, as well as insulin-stimulated glucose transport and translocation of GLUT4 and GLUT1 to the plasma membrane.	Tetradecanoylphorbol Acetate	92-95	solute carrier family 2 member 4	Rattus norvegicus	374-379
9406065-7	1997	Upon stimulation of EL-4.IL-2 with phorbol-12-myristate-13-acetate, there were variable increases in interleukin-2 secretion (up to 2.4-fold for 10(6) Bifidobacterium Bf-1/ml) and interleukin-5 secretion (up to 4.6-fold for 10(8) B. adolescentis M101-4).	Tetradecanoylphorbol Acetate	35-66	interleukin 2	Mus musculus	25-29
9406065-7	1997	Upon stimulation of EL-4.IL-2 with phorbol-12-myristate-13-acetate, there were variable increases in interleukin-2 secretion (up to 2.4-fold for 10(6) Bifidobacterium Bf-1/ml) and interleukin-5 secretion (up to 4.6-fold for 10(8) B. adolescentis M101-4).	Tetradecanoylphorbol Acetate	35-66	interleukin 2	Mus musculus	101-114
9406065-7	1997	Upon stimulation of EL-4.IL-2 with phorbol-12-myristate-13-acetate, there were variable increases in interleukin-2 secretion (up to 2.4-fold for 10(6) Bifidobacterium Bf-1/ml) and interleukin-5 secretion (up to 4.6-fold for 10(8) B. adolescentis M101-4).	Tetradecanoylphorbol Acetate	35-66	interleukin 5	Mus musculus	180-193
31207793-9	1997	Upon stimulation of EL4.IL-2 cells with phorbol 12-myristate-13-acetate, IL-2 secretion increased up to 1.9-fold in the presence of 106 L. bulgaricus Lr 79 cells per ml whereas this cytokine decreased in the presence of 107 or 108 lactobacilli per ml.	Tetradecanoylphorbol Acetate	40-71	interleukin 2	Mus musculus	24-28
31207793-9	1997	Upon stimulation of EL4.IL-2 cells with phorbol 12-myristate-13-acetate, IL-2 secretion increased up to 1.9-fold in the presence of 106 L. bulgaricus Lr 79 cells per ml whereas this cytokine decreased in the presence of 107 or 108 lactobacilli per ml.	Tetradecanoylphorbol Acetate	40-71	interleukin 2	Mus musculus	73-77
9346962-8	1997	Promyelocytic HL-60 cells, which expressed p130(SPA-1) with little p85/95(rap1GAP) in uninduced state, showed progressive decline in p130(SPA-1) and conversely drastic increase in p85/95(rap1GAP) as they ceased from proliferation and differentiated into macrophages by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	269-305	signal-induced proliferation-associated 1	Homo sapiens	43-53
9367827-5	1997	Further experiments demonstrated that in THP-1 cells pretreated with PMA, Dex potently synergized with IL-1 to stimulate G-CSF production.	Tetradecanoylphorbol Acetate	69-72	interleukin 1 alpha	Homo sapiens	103-107
9367827-5	1997	Further experiments demonstrated that in THP-1 cells pretreated with PMA, Dex potently synergized with IL-1 to stimulate G-CSF production.	Tetradecanoylphorbol Acetate	69-72	colony stimulating factor 3	Homo sapiens	121-126
9344614-8	1997	Our data demonstrate that 1-(carboxymethylthio)tetradecane-mediated changes in phospholipid structure and composition may affect PDGF- and TPA-mediated c-fos gene regulation in fibroblasts.	Tetradecanoylphorbol Acetate	139-142	FBJ osteosarcoma oncogene	Mus musculus	152-157
9362243-4	1997	Phorbol 12-myristate 13-acetate (PMA) suppressed both Kv4.2 and Kv4.3 currents as well as native I(to), but not after preincubation with PKC inhibitors (e.g., chelerythrine).	Tetradecanoylphorbol Acetate	0-31	potassium voltage-gated channel subfamily D member 2	Rattus norvegicus	54-59
9362243-4	1997	Phorbol 12-myristate 13-acetate (PMA) suppressed both Kv4.2 and Kv4.3 currents as well as native I(to), but not after preincubation with PKC inhibitors (e.g., chelerythrine).	Tetradecanoylphorbol Acetate	33-36	potassium voltage-gated channel subfamily D member 2	Rattus norvegicus	54-59
9344507-3	1997	LIF synthesis is enhanced in a dose-dependent manner after stimulation with lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMAS).	Tetradecanoylphorbol Acetate	105-136	LIF interleukin 6 family cytokine	Homo sapiens	0-3
9343304-6	1997	Pretreatment of conceptuses with 1 microM PMA for 12 h to produce PKC-deficient tissues or treatment with 50 mM calphostin C abolished the hGM-CSF-induced increase in oIFNtau mRNA.	Tetradecanoylphorbol Acetate	42-45	colony stimulating factor 2	Homo sapiens	139-146
9299495-1	1997	Transcription factor AP-1 induced by 12-O-tetradecanoylphorbol-13-acetate treatment of LLC-PK1 cells binds specifically to an AP-1 oligonucleotide.	Tetradecanoylphorbol Acetate	37-73	LOC106508708	Sus scrofa	0-25
9310485-4	1997	In the current study, the effect of dilazep on the expression of tissue factor (TF) in human umbilical vein endothelial cells (HUVECs) after the stimulation with tumor necrosis factor-alpha (TNF), thrombin, or phorbol 12-myristate 13-acetate (PMA) was evaluated.	Tetradecanoylphorbol Acetate	210-241	coagulation factor III, tissue factor	Homo sapiens	65-78
9310485-4	1997	In the current study, the effect of dilazep on the expression of tissue factor (TF) in human umbilical vein endothelial cells (HUVECs) after the stimulation with tumor necrosis factor-alpha (TNF), thrombin, or phorbol 12-myristate 13-acetate (PMA) was evaluated.	Tetradecanoylphorbol Acetate	210-241	coagulation factor III, tissue factor	Homo sapiens	80-82
9310485-6	1997	Dilazep inhibited TF activity induced on HUVECs by each stimulant, TNF (1000 U/mL), thrombin (25 nmol/L), or PMA (5 nmol/L) in a dose-dependent fashion (1 to 100 microg/mL).	Tetradecanoylphorbol Acetate	109-112	coagulation factor III, tissue factor	Homo sapiens	18-20
9294148-4	1997	SEK1(-/-) peripheral T cells showed decreased proliferation and IL-2 production after CD28 costimulation and PMA/Ca2+ ionophore activation.	Tetradecanoylphorbol Acetate	109-112	mitogen-activated protein kinase kinase 4	Mus musculus	0-4
9302656-4	1997	Brief exposure to a calcium ionophore or phorbol 12-myristate 13-acetate (PMA) stably enhanced PLA2 activity.	Tetradecanoylphorbol Acetate	41-72	phospholipase A2 group IB	Rattus norvegicus	95-99
9302656-4	1997	Brief exposure to a calcium ionophore or phorbol 12-myristate 13-acetate (PMA) stably enhanced PLA2 activity.	Tetradecanoylphorbol Acetate	74-77	phospholipase A2 group IB	Rattus norvegicus	95-99
9283699-6	1997	Determination by immunoassay of cytokine-induced neutrophil chemoattractant (CINC)-1, -2 alpha, -2 beta and -3 in the conditioned medium at 4 h revealed that staurosporine (64 nM) and TPA (49 nM) strongly stimulated the production of CINC-3 (staurosporine, 133.0 +/- 3.8; TPA, 26.7 +/- 1.0; control, 0.32 +/- 0.01 ng ml-1, means +/- s.e.mean from four samples) compared to CINC-1 (staurosporine, 55.0 +/- 1.2; TPA, 12.2 +/- 0.3; control, 0.56 +/- 0.01 ng ml-1), and CINC-2 alpha (staurosporine, 1.09 +/- 0.03; TPA, 0.90 +/- 0.02; control, &lt; 0.10 ng ml-1).	Tetradecanoylphorbol Acetate	184-187	C-X-C motif chemokine ligand 1	Rattus norvegicus	32-110
9389362-5	1997	Stimulation experiments of the different cell lines and primary tumour cells by the phorbol ester TPA and the B-cell specific stimulation with SAC/anti-IgM respectively indicated a change of the expression level in comparison with the unstimulated cells and, a higher molecular weight species of the protein tyrosine kinase p56lck was observed.	Tetradecanoylphorbol Acetate	98-101	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	324-330
9246608-4	1997	Brief exposure to a calcium ionophore or phorbol 12-myristate 13-acetate (PMA) stably enhanced PLA2 activity.	Tetradecanoylphorbol Acetate	41-72	phospholipase A2 group IB	Rattus norvegicus	95-99
9246608-4	1997	Brief exposure to a calcium ionophore or phorbol 12-myristate 13-acetate (PMA) stably enhanced PLA2 activity.	Tetradecanoylphorbol Acetate	74-77	phospholipase A2 group IB	Rattus norvegicus	95-99
9254887-4	1997	Cotransfection of K14TAM67 with luciferase plasmid reporter DNAs produced inhibition of basal and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 and NF kappa B activity but had no effect on p53-dependent transcriptional activity.	Tetradecanoylphorbol Acetate	136-139	transformation related protein 53, pseudogene	Mus musculus	199-202
9254887-9	1997	However, the combination of substantial levels of mRNA for stromelysin-1, stromelysin-2, collagenase, membrane type 1 MMP, and gelatinase A occurred only in TPA-treated cells in the absence of TAM67.	Tetradecanoylphorbol Acetate	157-160	matrix metallopeptidase 3	Mus musculus	59-72
9221949-6	1997	Activation of protein kinases A and C with 8Br.cAMP and tetradecanoylphorbolacetate, respectively, enhanced the PEnk gene expression only during the G1 phase.	Tetradecanoylphorbol Acetate	56-83	proenkephalin	Rattus norvegicus	112-116
9190901-5	1997	We have previously shown that ETS1 can transactivate GM-CSF in Jurkat T cells, but only after the cells have been stimulated by treatment with PMA and ionomycin, agents that mimic T cell activation.	Tetradecanoylphorbol Acetate	143-146	ETS proto-oncogene 1, transcription factor	Homo sapiens	30-34
9190901-6	1997	Thus we proposed that ETS1, which is expressed constitutively in Jurkat cells, may act in concert with PMA/ionomycin inducible factors.	Tetradecanoylphorbol Acetate	103-106	ETS proto-oncogene 1, transcription factor	Homo sapiens	22-26
9268491-5	1997	Similarly, when CBRH-7919 rat liver cancer cells were treated with phorbol 12-myristate 13-acetate, a proliferation stimulator of the cells, gamma-GT and Ca2+-dependent activities of PC-PLC and the expression of alpha-fetoprotein increased significantly.	Tetradecanoylphorbol Acetate	67-98	gamma-glutamyltransferase 1	Rattus norvegicus	141-149
9241533-1	1997	Leukosialin (CD43), the major sialoprotein on circulating leukocytes, has been previously described to be down-regulated on neutrophils following activation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	162-187	LOC105369247	Homo sapiens	0-11
9241533-1	1997	Leukosialin (CD43), the major sialoprotein on circulating leukocytes, has been previously described to be down-regulated on neutrophils following activation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	189-192	LOC105369247	Homo sapiens	0-11
9169347-5	1997	Agonists for protein kinase A (PKA) (forskolin), and protein kinase C (PKC) (phorbol 12-myristate 13-acetate; PMA) also stimulated IL-6/IL-11 production.	Tetradecanoylphorbol Acetate	77-108	interleukin 11	Homo sapiens	136-141
9177393-6	1997	This indicates a PKC- and PTK-mediated pathway triggered by TPA and EGF, respectively.	Tetradecanoylphorbol Acetate	60-63	protein tyrosine kinase 2 beta	Homo sapiens	26-29
9154324-16	1997	Treatment of the cells with PMA induced a time-dependent increase in the expression of both COX-1 and COX-2 mRNAs.	Tetradecanoylphorbol Acetate	28-31	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	92-97
9154324-19	1997	The enzymatic activity of the PMA-induced COX was measured in the presence of a panel of enzyme inhibitors, and the IC50 values obtained were compared with those obtained for the inhibition of human platelet COX activity, a COX-1 selective assay.	Tetradecanoylphorbol Acetate	30-33	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	224-229
9129233-0	1997	Analysis of the ability of 12-O-tetradecanoylphorbol-13-acetate to induce epidermal hyperplasia, transforming growth factor-alpha, and skin tumor promotion in wa-1 mice.	Tetradecanoylphorbol Acetate	27-63	transforming growth factor alpha	Mus musculus	97-129
9099734-0	1997	Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin.	Tetradecanoylphorbol Acetate	115-140	paxillin	Homo sapiens	178-186
9099734-2	1997	Stem cell factor, which potentiates the growth of megakaryocytes and their progenitors, and phorbol myristate acetate, which causes differentiation of megakaryocytic cell lines, induced the tyrosine phosphorylation of RAFTK but not of focal adhesion kinase.	Tetradecanoylphorbol Acetate	92-117	protein tyrosine kinase 2 beta	Homo sapiens	218-223
9099734-5	1997	Cytochalasin D, which disrupts the cytoskeleton, abolished the phosphorylation of RAFTK upon phorbol myristate acetate and stem cell factor stimulation, indicating that RAFTK association with the actin cytoskeleton appears to be critical for its phosphorylation.	Tetradecanoylphorbol Acetate	93-118	protein tyrosine kinase 2 beta	Homo sapiens	82-87
9099734-5	1997	Cytochalasin D, which disrupts the cytoskeleton, abolished the phosphorylation of RAFTK upon phorbol myristate acetate and stem cell factor stimulation, indicating that RAFTK association with the actin cytoskeleton appears to be critical for its phosphorylation.	Tetradecanoylphorbol Acetate	93-118	protein tyrosine kinase 2 beta	Homo sapiens	169-174
9099734-8	1997	Transient overexpression of a dominant-negative mutant of RAFTK inhibited significantly the tyrosine phosphorylation of paxillin upon phorbol myristate acetate stimulation.	Tetradecanoylphorbol Acetate	134-159	protein tyrosine kinase 2 beta	Homo sapiens	58-63
9099734-8	1997	Transient overexpression of a dominant-negative mutant of RAFTK inhibited significantly the tyrosine phosphorylation of paxillin upon phorbol myristate acetate stimulation.	Tetradecanoylphorbol Acetate	134-159	paxillin	Homo sapiens	120-128
9092538-6	1997	Phorbol 12-myristate 13-acetate stimulation induced serine phosphorylation of Cbl, and dephosphorylation of immunoprecipitated Cbl by a Ser/Thr phosphatase disrupted its interaction with 14-3-3.	Tetradecanoylphorbol Acetate	0-31	Cbl proto-oncogene	Homo sapiens	78-81
9092538-6	1997	Phorbol 12-myristate 13-acetate stimulation induced serine phosphorylation of Cbl, and dephosphorylation of immunoprecipitated Cbl by a Ser/Thr phosphatase disrupted its interaction with 14-3-3.	Tetradecanoylphorbol Acetate	0-31	Cbl proto-oncogene	Homo sapiens	127-130
9142914-5	1997	Gastrin stimulation increased c-fos and c-jun mRNA abundance and AP-1-dependent transcriptional activity, as assessed by a reporter construct in which the CAT reporter gene is under the control of a 12-O-tetradecanoylphorbol-13-acetate response element multimer.	Tetradecanoylphorbol Acetate	199-235	gastrin	Homo sapiens	0-7
9168444-8	1997	TPA delayed DNA synthesis and expression of these genes, and suppressed Cdc2 kinase activity in the second round G2/M phase.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase 1	Homo sapiens	72-76
9144967-5	1997	In contrast, treatment of the tuber discs with 12-O-tetradecanoylphorbol 13-acetate (TPA), an activator of PKC, led to an increase in binding of PBF-2 to the ERE and the corresponding increase in the level of the PR-10a protein, mimicking the effect seen with the elicitor arachidonic acid.	Tetradecanoylphorbol Acetate	47-83	single-stranded DNA-binding protein WHY1, chloroplastic	Solanum tuberosum	145-150
9144967-5	1997	In contrast, treatment of the tuber discs with 12-O-tetradecanoylphorbol 13-acetate (TPA), an activator of PKC, led to an increase in binding of PBF-2 to the ERE and the corresponding increase in the level of the PR-10a protein, mimicking the effect seen with the elicitor arachidonic acid.	Tetradecanoylphorbol Acetate	85-88	single-stranded DNA-binding protein WHY1, chloroplastic	Solanum tuberosum	145-150
9136987-8	1997	In mouse epidermis following multiple treatments with 12-O-tetradecanoylphorbol-13-acetate (TPA), the phosphotyrosine content of erbB2 was significantly elevated in a dose-dependent manner.	Tetradecanoylphorbol Acetate	54-90	erb-b2 receptor tyrosine kinase 2	Mus musculus	129-134
9136987-8	1997	In mouse epidermis following multiple treatments with 12-O-tetradecanoylphorbol-13-acetate (TPA), the phosphotyrosine content of erbB2 was significantly elevated in a dose-dependent manner.	Tetradecanoylphorbol Acetate	92-95	erb-b2 receptor tyrosine kinase 2	Mus musculus	129-134
9136987-9	1997	Concomittantly, erbB2:EGFr heterodimer formation and c-src kinase activity were also elevated in TPA-treated epidermis.	Tetradecanoylphorbol Acetate	97-100	erb-b2 receptor tyrosine kinase 2	Mus musculus	16-21
9136987-9	1997	Concomittantly, erbB2:EGFr heterodimer formation and c-src kinase activity were also elevated in TPA-treated epidermis.	Tetradecanoylphorbol Acetate	97-100	epidermal growth factor receptor	Mus musculus	22-26
9087164-3	1997	We show here that LFA-1-mediated adhesion of TAM2D2 T-cell hybridoma cells to ICAM-1 can in fact be induced by direct activation of G-proteins using AIF-4, to the same extent as by using PMA or Mn2+.	Tetradecanoylphorbol Acetate	187-190	integrin alpha L	Mus musculus	18-23
9099902-8	1997	Combined stimulation with TPA and the calcium ionophore ionomycin resulted in strong synergistic induction of luciferase activity from the LIF promoter.	Tetradecanoylphorbol Acetate	26-29	LIF interleukin 6 family cytokine	Homo sapiens	139-142
9099902-11	1997	Both hormones strongly inhibited the stimulation of the LIF promoter by TPA and ionomycin.	Tetradecanoylphorbol Acetate	72-75	LIF interleukin 6 family cytokine	Homo sapiens	56-59
9224725-1	1997	12-O-Tetradecanoylphorbol 13-acetate (TPA) induces HL-60 cells to differentiate along the monocyte/macrophage pathway and stimulates expression of the extracellular adhesion protein osteopontin (OPN).	Tetradecanoylphorbol Acetate	0-36	secreted phosphoprotein 1	Homo sapiens	182-193
9224725-1	1997	12-O-Tetradecanoylphorbol 13-acetate (TPA) induces HL-60 cells to differentiate along the monocyte/macrophage pathway and stimulates expression of the extracellular adhesion protein osteopontin (OPN).	Tetradecanoylphorbol Acetate	0-36	secreted phosphoprotein 1	Homo sapiens	195-198
9224725-1	1997	12-O-Tetradecanoylphorbol 13-acetate (TPA) induces HL-60 cells to differentiate along the monocyte/macrophage pathway and stimulates expression of the extracellular adhesion protein osteopontin (OPN).	Tetradecanoylphorbol Acetate	38-41	secreted phosphoprotein 1	Homo sapiens	182-193
9224725-1	1997	12-O-Tetradecanoylphorbol 13-acetate (TPA) induces HL-60 cells to differentiate along the monocyte/macrophage pathway and stimulates expression of the extracellular adhesion protein osteopontin (OPN).	Tetradecanoylphorbol Acetate	38-41	secreted phosphoprotein 1	Homo sapiens	195-198
9224725-2	1997	In this study, the mechanism of TPA-mediated OPN mRNA expression and its relationship to differentiation were investigated.	Tetradecanoylphorbol Acetate	32-35	secreted phosphoprotein 1	Homo sapiens	45-48
9224725-3	1997	The induction of OPN mRNA by TPA was dose dependently inhibited by staurosporine (0.4-10.0 nM) and chelerythrine (0.1-5.0 microM), indicating that OPN expression requires PKC activation.	Tetradecanoylphorbol Acetate	29-32	secreted phosphoprotein 1	Homo sapiens	17-20
9224725-3	1997	The induction of OPN mRNA by TPA was dose dependently inhibited by staurosporine (0.4-10.0 nM) and chelerythrine (0.1-5.0 microM), indicating that OPN expression requires PKC activation.	Tetradecanoylphorbol Acetate	29-32	secreted phosphoprotein 1	Homo sapiens	147-150
20035290-4	2009	L-cystathionine, L-cysteine and NAc-L-cysteine suppressed PMA-induced serine/threonine phosphorylation and the translocation of cytosolic compounds to the cell membrane.	Tetradecanoylphorbol Acetate	58-61	synuclein alpha	Homo sapiens	32-35
9224725-5	1997	Cycloheximide (10 microg/ml) ablated the induction of OPN mRNA by TPA.	Tetradecanoylphorbol Acetate	66-69	secreted phosphoprotein 1	Homo sapiens	54-57
9224725-8	1997	Treatment with TPA subsequent to a 120-h pretreatment with retinoic acid (RA), 9-cis-RA, or calcitriol resulted in a potentiation of the induction of OPN mRNA.	Tetradecanoylphorbol Acetate	15-18	secreted phosphoprotein 1	Homo sapiens	150-153
9224725-11	1997	Thus, TPA-stimulated transcription of the OPN gene apparently occurs via a PKC/MAPK-dependent mechanism that is independent of that associated with differentiation and is not dependent on the maturational state of these cells.	Tetradecanoylphorbol Acetate	6-9	secreted phosphoprotein 1	Homo sapiens	42-45
9202001-7	1997	This differential substrate specificity of MKP-1 can be functionally extended to nuclear transcriptional events in that PMA-induced c-Jun transcriptional activity was more sensitive to inhibition by MKP-1 than either Elk-1 or c-Myc.	Tetradecanoylphorbol Acetate	120-123	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	226-231
9120401-7	1997	Furthermore, both T and B cells lacking RelA showed marked reduction in proliferative responses to stimulation with Con A, anti-CD3, anti-CD3 + anti-CD28, LPS, anti-IgM, and PMA + calcium ionophore.	Tetradecanoylphorbol Acetate	174-177	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	40-44
9057647-5	1997	Surprisingly, all RU clones resisted the suppressing effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on c-myc oncogene expression and cell proliferation.	Tetradecanoylphorbol Acetate	63-99	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	109-114
9057647-5	1997	Surprisingly, all RU clones resisted the suppressing effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on c-myc oncogene expression and cell proliferation.	Tetradecanoylphorbol Acetate	101-104	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	109-114
9301678-5	1997	Expression of the c-myc gene was down-regulated and c-jun and c-fms transcripts increased following exposure to 5-500 nM TPA.	Tetradecanoylphorbol Acetate	121-124	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
19765648-9	2009	Moreover, BI-D1870 also prevented PMA-induced glucose transport in 3T3-L1 adipocytes further suggesting a role for p90RSK in regulating uptake of glucose into the cells.	Tetradecanoylphorbol Acetate	34-37	ribosomal protein S6 kinase A1	Homo sapiens	115-121
9301678-6	1997	In contrast, exposure to 0.5 nM TPA decreased c-myc expression and increased c-jun transcripts only transiently between 4 and 8 h while little if any effect was detectable on c-fms mRNA expression and subsequent differentiation.	Tetradecanoylphorbol Acetate	32-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	46-51
9225005-3	1997	We found that the PKC activator, bryostatin, like PMA, induced the conversion of p56lck to a slower migrating form with an apparent molecular mass of 60 kDa.	Tetradecanoylphorbol Acetate	50-53	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	81-87
9225005-8	1997	We found that a 36- to 38-kDa tyrosine phosphoprotein co-immunoprecipitated with Lck from cells that were treated for 24 hr with PMA, but not bryostatin.	Tetradecanoylphorbol Acetate	129-132	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	81-84
9032234-1	1997	Treatment of human pleural mesothelioma (MS-1) cells with phorbol myristate acetate (PMA) and cycloheximide results in 17- and 10-fold, respectively, increases in steady-state expression of urokinase-type plasminogen activator receptor (uPAR) mRNA.	Tetradecanoylphorbol Acetate	58-83	plasminogen activator, urokinase receptor	Homo sapiens	190-235
19554423-9	2009	Conversely, activation of PKC by phorbol 12-myristate 13-acetate (PMA) upregulated the ODC/polyamine system, whereas the PKC inhibitor chelerythrine (Che) downregulated the ODC/polyamine system.	Tetradecanoylphorbol Acetate	33-64	ornithine decarboxylase 1	Rattus norvegicus	87-90
9032234-1	1997	Treatment of human pleural mesothelioma (MS-1) cells with phorbol myristate acetate (PMA) and cycloheximide results in 17- and 10-fold, respectively, increases in steady-state expression of urokinase-type plasminogen activator receptor (uPAR) mRNA.	Tetradecanoylphorbol Acetate	58-83	plasminogen activator, urokinase receptor	Homo sapiens	237-241
9032234-1	1997	Treatment of human pleural mesothelioma (MS-1) cells with phorbol myristate acetate (PMA) and cycloheximide results in 17- and 10-fold, respectively, increases in steady-state expression of urokinase-type plasminogen activator receptor (uPAR) mRNA.	Tetradecanoylphorbol Acetate	85-88	plasminogen activator, urokinase receptor	Homo sapiens	190-235
9032234-1	1997	Treatment of human pleural mesothelioma (MS-1) cells with phorbol myristate acetate (PMA) and cycloheximide results in 17- and 10-fold, respectively, increases in steady-state expression of urokinase-type plasminogen activator receptor (uPAR) mRNA.	Tetradecanoylphorbol Acetate	85-88	plasminogen activator, urokinase receptor	Homo sapiens	237-241
9032234-2	1997	Studies of transcriptional inhibition by actinomycin D showed four- and sixfold extensions of uPAR mRNA half-life in MS-1 cells treated with PMA and cycloheximide, respectively, suggesting that uPAR gene expression involves a posttranscriptional regulatory mechanism.	Tetradecanoylphorbol Acetate	141-144	plasminogen activator, urokinase receptor	Homo sapiens	94-98
9032234-2	1997	Studies of transcriptional inhibition by actinomycin D showed four- and sixfold extensions of uPAR mRNA half-life in MS-1 cells treated with PMA and cycloheximide, respectively, suggesting that uPAR gene expression involves a posttranscriptional regulatory mechanism.	Tetradecanoylphorbol Acetate	141-144	plasminogen activator, urokinase receptor	Homo sapiens	194-198
9214631-7	1997	Moreover, when the function of p90rsk1 is impaired by expression of a dominant-negative mutant, IkappaB alpha degradation in response to mitogenic stimuli, e.g. 12-O-tetradecanoylphorbol 13-acetate (TPA), is inhibited.	Tetradecanoylphorbol Acetate	161-197	ribosomal protein S6 kinase A1	Homo sapiens	31-38
9214631-7	1997	Moreover, when the function of p90rsk1 is impaired by expression of a dominant-negative mutant, IkappaB alpha degradation in response to mitogenic stimuli, e.g. 12-O-tetradecanoylphorbol 13-acetate (TPA), is inhibited.	Tetradecanoylphorbol Acetate	199-202	ribosomal protein S6 kinase A1	Homo sapiens	31-38
9191470-7	1997	The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway.	Tetradecanoylphorbol Acetate	240-265	plasminogen activator, urokinase receptor	Homo sapiens	35-40
9012737-10	1997	The fatty acids also inhibited the expression of ICAM-1 and E-selectin induced by phorbol 12-myristate 13-acetate, showing that inhibition occurred at a post-TNF-alpha receptor binding level.	Tetradecanoylphorbol Acetate	82-113	selectin E	Homo sapiens	60-70
19554423-9	2009	Conversely, activation of PKC by phorbol 12-myristate 13-acetate (PMA) upregulated the ODC/polyamine system, whereas the PKC inhibitor chelerythrine (Che) downregulated the ODC/polyamine system.	Tetradecanoylphorbol Acetate	66-69	ornithine decarboxylase 1	Rattus norvegicus	87-90
19773750-6	2009	Melatonin 1 nM was able to counteract the stimulatory effect of tetradecanoyl phorbol acetate on PGE(2) production and inhibit COX-2 and COX-1 mRNA expression.	Tetradecanoylphorbol Acetate	64-93	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	137-142
9190210-5	1997	Overexpression of Ets-1 augments the response to PMA/ionomycin and this is reduced by mutation of EBS4.	Tetradecanoylphorbol Acetate	49-52	ETS proto-oncogene 1, transcription factor	Homo sapiens	18-23
9190210-7	1997	This activation is only partly affected by mutation of EBS4, and a mutant promoter that binds Ets-1, but not Elf-1, at the EBS4 site responds to PMA/ionomycin as efficiently as the wild-type.	Tetradecanoylphorbol Acetate	145-148	ETS proto-oncogene 1, transcription factor	Homo sapiens	94-99
9190210-7	1997	This activation is only partly affected by mutation of EBS4, and a mutant promoter that binds Ets-1, but not Elf-1, at the EBS4 site responds to PMA/ionomycin as efficiently as the wild-type.	Tetradecanoylphorbol Acetate	145-148	keratin 14	Homo sapiens	123-127
9015316-14	1997	Increased levels of alpha2 and MMP-1 mRNA in collagen gel-stimulated fibroblasts were abrogated by bisindolylmaleimide GF 109203X and calphostin C, chemical inhibitors for PKC, but retained when cells were depleted of 12-myristate 13-acetate (PMA)-inducible PKC isoforms by 24 h of pretreatment with phorbol PMA.	Tetradecanoylphorbol Acetate	243-246	matrix metallopeptidase 1	Homo sapiens	31-36
8999923-9	1997	However, phorbol 12-myristate 13-acetate treatment had only a limited effect on EGF binding and EGF-stimulated tyrosine kinase activity in cells expressing EGFR/RET chimeras.	Tetradecanoylphorbol Acetate	9-40	epidermal growth factor receptor	Mus musculus	156-160
9018131-1	1997	Previous studies have shown that the ZII element in the BZLF1 promoter (P1) is responsive to TPA and anti-immunoglobulin induction.	Tetradecanoylphorbol Acetate	93-96	protein Zta	Human gammaherpesvirus 4	56-61
8999881-4	1997	In contrast, 12-O-tetradecanoylphorbol-13-acetate strongly activated p90(RSK) but only weakly stimulated p70(S6K).	Tetradecanoylphorbol Acetate	13-49	ribosomal protein S6 kinase A1	Homo sapiens	69-77
8999881-4	1997	In contrast, 12-O-tetradecanoylphorbol-13-acetate strongly activated p90(RSK) but only weakly stimulated p70(S6K).	Tetradecanoylphorbol Acetate	13-49	ribosomal protein S6 kinase B1	Homo sapiens	109-112
9000576-1	1997	Growth arrest and differentiation of leukemic cells by phorbol 12-myristate 13-acetate (PMA) is accompanied by p53-independent activation of p21WAF1/CIP1 and c-myc down-regulation.	Tetradecanoylphorbol Acetate	55-86	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	158-163
9000576-1	1997	Growth arrest and differentiation of leukemic cells by phorbol 12-myristate 13-acetate (PMA) is accompanied by p53-independent activation of p21WAF1/CIP1 and c-myc down-regulation.	Tetradecanoylphorbol Acetate	88-91	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	158-163
9000576-2	1997	We show that despite p21 induction in 7 of 12 human cancer cell lines treated with PMA, growth inhibition was observed only in two cell lines (SKBr3 breast and LNCaP prostate cancer cells).	Tetradecanoylphorbol Acetate	83-86	H3 histone pseudogene 16	Homo sapiens	21-24
9000576-7	1997	Our findings suggest that induction of p21 and down-regulation of c-myc may be necessary steps in a PMA-induced growth-inhibitory pathway in cancer cells.	Tetradecanoylphorbol Acetate	100-103	H3 histone pseudogene 16	Homo sapiens	39-42
9000576-7	1997	Our findings suggest that induction of p21 and down-regulation of c-myc may be necessary steps in a PMA-induced growth-inhibitory pathway in cancer cells.	Tetradecanoylphorbol Acetate	100-103	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	66-71
9002947-4	1997	Although the expression of Src-related kinases is also upregulated more rapidly than cortactin in PMA-treated CMK cells, tyrosine phosphorylation of cortactin appears to be only transiently elevated 4 days after PMA stimulation.	Tetradecanoylphorbol Acetate	98-101	cortactin	Mus musculus	85-94
9002947-4	1997	Although the expression of Src-related kinases is also upregulated more rapidly than cortactin in PMA-treated CMK cells, tyrosine phosphorylation of cortactin appears to be only transiently elevated 4 days after PMA stimulation.	Tetradecanoylphorbol Acetate	98-101	chemokine (C-X-C motif) ligand 9	Mus musculus	110-113
9215804-6	1997	B[a]P 10 microM initiated the oxidation of DNA and protein, and the formation of micronuclei, all of which were enhanced over 2-fold by the dual CYP1A1/PHS inducer TCDD 10 nM, as well as by other PHS inducers, 12-O-tetradecanoylphorbol-13-acetate 1 microM and interleukin-1alpha 0.625 or 1.25 ng/ml, that do not induce CYP1A1 (p &lt; .05).	Tetradecanoylphorbol Acetate	210-246	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	145-151
9015756-6	1997	The expression of c-src, c-fms, and macrophage colony stimulating factor (M-CSF) was induced by TPA treatment; however, TPA-induced M-CSF gene transcription was attenuated by the subsequent addition of 1,25-(OH)2D3.	Tetradecanoylphorbol Acetate	96-99	colony stimulating factor 1	Homo sapiens	36-72
9015756-6	1997	The expression of c-src, c-fms, and macrophage colony stimulating factor (M-CSF) was induced by TPA treatment; however, TPA-induced M-CSF gene transcription was attenuated by the subsequent addition of 1,25-(OH)2D3.	Tetradecanoylphorbol Acetate	96-99	colony stimulating factor 1	Homo sapiens	74-79
9015756-6	1997	The expression of c-src, c-fms, and macrophage colony stimulating factor (M-CSF) was induced by TPA treatment; however, TPA-induced M-CSF gene transcription was attenuated by the subsequent addition of 1,25-(OH)2D3.	Tetradecanoylphorbol Acetate	120-123	colony stimulating factor 1	Homo sapiens	36-72
9015756-6	1997	The expression of c-src, c-fms, and macrophage colony stimulating factor (M-CSF) was induced by TPA treatment; however, TPA-induced M-CSF gene transcription was attenuated by the subsequent addition of 1,25-(OH)2D3.	Tetradecanoylphorbol Acetate	120-123	colony stimulating factor 1	Homo sapiens	74-79
9015756-6	1997	The expression of c-src, c-fms, and macrophage colony stimulating factor (M-CSF) was induced by TPA treatment; however, TPA-induced M-CSF gene transcription was attenuated by the subsequent addition of 1,25-(OH)2D3.	Tetradecanoylphorbol Acetate	120-123	colony stimulating factor 1	Homo sapiens	132-137
9000119-5	1997	Although EGCG did not directly inhibit the production of GM-CSF, it did inhibit the effect of TNF-alpha or TPA, both of which stimulated AML cells to produce GM-CSF.	Tetradecanoylphorbol Acetate	107-110	colony stimulating factor 2	Homo sapiens	158-164
9017603-6	1997	Translocation of mNFATx1 correlated well with activation of the murine IL-2 promoter; mNFATx1 translocated under conditions described above, in combination with phorbol 12-myristate 13-acetate, activated the transiently transfected murine IL-2 promoter.	Tetradecanoylphorbol Acetate	161-192	interleukin 2	Mus musculus	71-75
9017603-6	1997	Translocation of mNFATx1 correlated well with activation of the murine IL-2 promoter; mNFATx1 translocated under conditions described above, in combination with phorbol 12-myristate 13-acetate, activated the transiently transfected murine IL-2 promoter.	Tetradecanoylphorbol Acetate	161-192	interleukin 2	Mus musculus	239-243
8943287-7	1996	Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA; &gt;8 h) reduced IRS-1 content and down-regulated the novel PKC-delta isoform.	Tetradecanoylphorbol Acetate	20-56	insulin receptor substrate 1	Homo sapiens	80-85
8943287-7	1996	Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA; &gt;8 h) reduced IRS-1 content and down-regulated the novel PKC-delta isoform.	Tetradecanoylphorbol Acetate	58-61	insulin receptor substrate 1	Homo sapiens	80-85
8943287-8	1996	Bryostatin 1 inhibited TPA-induced depletion of both IRS-1 and PKC-delta expression in MCF-7 cells.	Tetradecanoylphorbol Acetate	23-26	insulin receptor substrate 1	Homo sapiens	53-58
8943287-9	1996	Associated with TPA-induced reduction in IRS-1 content was a reduction in IRS-1 transcription.	Tetradecanoylphorbol Acetate	16-19	insulin receptor substrate 1	Homo sapiens	41-46
8943287-9	1996	Associated with TPA-induced reduction in IRS-1 content was a reduction in IRS-1 transcription.	Tetradecanoylphorbol Acetate	16-19	insulin receptor substrate 1	Homo sapiens	74-79
8997261-7	1996	The TPA-induced increase in H82 cell attachment to EC was inhibited by addition of anti-P-sel antibodies but not by addition of anti-E-selectin antibodies.	Tetradecanoylphorbol Acetate	4-7	selectin P	Homo sapiens	88-93
8997261-10	1996	In addition, prolonged exposure of EC to TPA resulted in decreased expression of the PKC-alpha and PKC-epsilon isoforms.	Tetradecanoylphorbol Acetate	41-44	protein kinase C epsilon	Homo sapiens	99-110
9010772-4	1996	In the present study, we obtained evidence that the transferase and p33 were released into the extracellular space by the stimulus of calcium ionophore A23187 or serum-opsonized zymosan, but scarcely by phorbol myristate acetate (PMA) or N-formyl-Met-Leu-Phe (fMLP), thereby indicating the co-localization of the transferase and p33 in the azurophilic granules, and not in specific granules.	Tetradecanoylphorbol Acetate	203-228	leukocyte cell derived chemotaxin 2	Gallus gallus	68-71
9010772-4	1996	In the present study, we obtained evidence that the transferase and p33 were released into the extracellular space by the stimulus of calcium ionophore A23187 or serum-opsonized zymosan, but scarcely by phorbol myristate acetate (PMA) or N-formyl-Met-Leu-Phe (fMLP), thereby indicating the co-localization of the transferase and p33 in the azurophilic granules, and not in specific granules.	Tetradecanoylphorbol Acetate	230-233	leukocyte cell derived chemotaxin 2	Gallus gallus	68-71
8961146-3	1996	Mice receiving the tPA-gp120 DNA developed antigen-specific antibody responses against recombinant gp120 protein and the V2 peptide neutralization epitope as determined by ELISA.	Tetradecanoylphorbol Acetate	19-22	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	23-28
8961146-3	1996	Mice receiving the tPA-gp120 DNA developed antigen-specific antibody responses against recombinant gp120 protein and the V2 peptide neutralization epitope as determined by ELISA.	Tetradecanoylphorbol Acetate	19-22	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	99-104
8961146-8	1996	Nonhuman primates vaccinated with tPA-gp120 DNA also showed antigen-specific T lymphocyte proliferative and humoral responses, including moderate levels of neutralizing sera against homologous HIV.	Tetradecanoylphorbol Acetate	34-37	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	38-43
8910543-4	1996	These effects were blocked by EGTA or by protein kinase C inhibitors (RO31-8220; GF109203X) and mimicked by ionomycin or phorbol 12-myristate 13-acetate, in the case of pp125(FAK), or their combination in the case of PYK2/CAKbeta.	Tetradecanoylphorbol Acetate	121-152	protein tyrosine kinase 2	Rattus norvegicus	175-178
8948648-7	1996	In the Tst-1/Oct6 gene enhancer, a TPA response element was found in close proximity to the estrogen receptor binding site.	Tetradecanoylphorbol Acetate	35-38	estrogen receptor 1 (alpha)	Mus musculus	92-109
8948648-8	1996	As a consequence, TPA and estrogen activated transcription of the Tst-1/Oct6 gene in a synergistic manner.	Tetradecanoylphorbol Acetate	18-21	POU domain, class 3, transcription factor 1	Mus musculus	66-71
8948648-8	1996	As a consequence, TPA and estrogen activated transcription of the Tst-1/Oct6 gene in a synergistic manner.	Tetradecanoylphorbol Acetate	18-21	POU domain, class 3, transcription factor 1	Mus musculus	72-76
8915773-11	1996	Acute pretreatment of cells with PMA reduced concomitantly the amounts of PKC alpha, but not of PKC epsilon, and the subsequent activation of PLD elicited by PKC activators.	Tetradecanoylphorbol Acetate	33-36	protein kinase C epsilon	Homo sapiens	96-107
8920856-6	1996	Moreover, AP-1 activity stimulated by anti-TCR Abs or PMA/ionomycin was further increased by c-Rel overexpression.	Tetradecanoylphorbol Acetate	54-57	reticuloendotheliosis oncogene	Mus musculus	93-98
8930166-5	1996	Our pharmacological study suggests that, in neutrophil-like HL-60 cells, the signaling pathways leading to PMA-stimulated O2- generation appear to involve PKC, MAPK, phospholipase A2, arachidonic acid, PSP 1 and 2a and PTP.	Tetradecanoylphorbol Acetate	107-110	paraspeckle component 1	Homo sapiens	202-214
8824276-3	1996	In the present study, we examined the effects of phorbol 12-myristate 13-acetate, a potent PKC activator, on the ligand-induced transcriptional activation of the CYP1A1 gene and cellular function of the AhR in human HepG2 101L cells.	Tetradecanoylphorbol Acetate	49-80	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	162-168
8871604-6	1996	Phorbol 12-myristate 13-acetate (PMA), an activator of PKC, resembled IL4 in decreasing the expression of CD38, and either staurosporine or H7 abolished this effect.	Tetradecanoylphorbol Acetate	0-31	CD38 molecule	Homo sapiens	106-110
8871604-6	1996	Phorbol 12-myristate 13-acetate (PMA), an activator of PKC, resembled IL4 in decreasing the expression of CD38, and either staurosporine or H7 abolished this effect.	Tetradecanoylphorbol Acetate	33-36	CD38 molecule	Homo sapiens	106-110
9191470-7	1997	The IL-1 beta-mediated increase in u-PAR mRNA is inhibited by: (1) the relatively specific protein kinase C (PKC) inhibitors 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) and calphostin C; and (2) prolonged pretreatment of cells with phorbol myristate acetate (PMA), suggesting that PKC is an important component of the signaling pathway.	Tetradecanoylphorbol Acetate	267-270	plasminogen activator, urokinase receptor	Homo sapiens	35-40
9208127-7	1997	TPA (100 nM) attentuated p53 up-regulation elicited by the NO-releasing compounds, S-nitrosoglutathione (1 mM) and sodium nitroprusside (1 mM), and suppressed p53 protein accumulation in response to endogenously generated NO.	Tetradecanoylphorbol Acetate	0-3	transformation related protein 53, pseudogene	Mus musculus	25-28
9208127-7	1997	TPA (100 nM) attentuated p53 up-regulation elicited by the NO-releasing compounds, S-nitrosoglutathione (1 mM) and sodium nitroprusside (1 mM), and suppressed p53 protein accumulation in response to endogenously generated NO.	Tetradecanoylphorbol Acetate	0-3	transformation related protein 53, pseudogene	Mus musculus	159-162
9208127-8	1997	Hence, TPA appeared to lower the steady state p53 level following its up-regulation by NO.	Tetradecanoylphorbol Acetate	7-10	transformation related protein 53, pseudogene	Mus musculus	46-49
9208127-14	1997	By extending the studies, we revealed a TPA-mediated p53 down-regulation in response to etoposide (50 microM), mitomycin C (5 micrograms ml-1) and actinomycin D (2 micrograms ml-1).	Tetradecanoylphorbol Acetate	40-43	transformation related protein 53, pseudogene	Mus musculus	53-56
9208127-16	1997	With the notion that TPA suppressed apoptotic DNA fragmentation in p53 antisense expressing cells as well, we searched for additional inhibitory actions of TPA.	Tetradecanoylphorbol Acetate	21-24	transformation related protein 53, pseudogene	Mus musculus	67-70
9208127-17	1997	As well as affecting p53, TPA elicited a rapid decline of the steady state level of Bax within 30 min.	Tetradecanoylphorbol Acetate	26-29	transformation related protein 53, pseudogene	Mus musculus	21-24
9175775-7	1997	Tetradecanoylphorbol acetate (TPA) and fetal calf serum also stimulated nuclear p70S6K as judged by gel mobility shift.	Tetradecanoylphorbol Acetate	0-28	ribosomal protein S6 kinase B1	Homo sapiens	80-86
9175775-7	1997	Tetradecanoylphorbol acetate (TPA) and fetal calf serum also stimulated nuclear p70S6K as judged by gel mobility shift.	Tetradecanoylphorbol Acetate	30-33	ribosomal protein S6 kinase B1	Homo sapiens	80-86
9175775-8	1997	TPA also promoted a decrease in cytosolic p70S6K and an increase in nuclear enzyme suggestive of translocation of the enzyme.	Tetradecanoylphorbol Acetate	0-3	ribosomal protein S6 kinase B1	Homo sapiens	42-48
9175775-10	1997	Thus, nuclear p70S6K is regulated by insulin, serum and TPA.	Tetradecanoylphorbol Acetate	56-59	ribosomal protein S6 kinase B1	Homo sapiens	14-20
9135025-10	1997	Phorbol 12-myristate 13-acetate treatment progressively caused a decrease of CD97 antigen expression in all cell lines to about 30% of their initial levels after 48 h. Immunohistochemical staining of SW 1736 cells revealed that CD97 is located in most of the cell compartments and suggested a CD97 internalization process after phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	0-31	adhesion G protein-coupled receptor E5	Homo sapiens	77-81
9135025-10	1997	Phorbol 12-myristate 13-acetate treatment progressively caused a decrease of CD97 antigen expression in all cell lines to about 30% of their initial levels after 48 h. Immunohistochemical staining of SW 1736 cells revealed that CD97 is located in most of the cell compartments and suggested a CD97 internalization process after phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	0-31	adhesion G protein-coupled receptor E5	Homo sapiens	228-232
9135025-10	1997	Phorbol 12-myristate 13-acetate treatment progressively caused a decrease of CD97 antigen expression in all cell lines to about 30% of their initial levels after 48 h. Immunohistochemical staining of SW 1736 cells revealed that CD97 is located in most of the cell compartments and suggested a CD97 internalization process after phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	0-31	adhesion G protein-coupled receptor E5	Homo sapiens	228-232
9135025-10	1997	Phorbol 12-myristate 13-acetate treatment progressively caused a decrease of CD97 antigen expression in all cell lines to about 30% of their initial levels after 48 h. Immunohistochemical staining of SW 1736 cells revealed that CD97 is located in most of the cell compartments and suggested a CD97 internalization process after phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	328-359	adhesion G protein-coupled receptor E5	Homo sapiens	228-232
9135025-10	1997	Phorbol 12-myristate 13-acetate treatment progressively caused a decrease of CD97 antigen expression in all cell lines to about 30% of their initial levels after 48 h. Immunohistochemical staining of SW 1736 cells revealed that CD97 is located in most of the cell compartments and suggested a CD97 internalization process after phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	328-359	adhesion G protein-coupled receptor E5	Homo sapiens	228-232
9247605-2	1997	We investigated the effects of TPA on the expression of vimentin during the differentiation of THP-1 cells at both the mRNA and the protein level.	Tetradecanoylphorbol Acetate	31-34	vimentin	Homo sapiens	56-64
9247605-3	1997	On northern blotting analysis, a 2.1 kb vimentin mRNA was up-regulated by TPA.	Tetradecanoylphorbol Acetate	74-77	vimentin	Homo sapiens	40-48
9247605-4	1997	On western blotting, small vimentin molecules with a molecular mass of approximately 40 kDa were observed in the soluble fraction and increased with TPA-induction of cellular differentiation.	Tetradecanoylphorbol Acetate	149-152	vimentin	Homo sapiens	27-35
9247605-9	1997	TPA-treated THP-1 cells were found to express a vimentin-filament network based on immunocytochemical analysis using an anti-vimentin monoclonal antibody, V9.	Tetradecanoylphorbol Acetate	0-3	vimentin	Homo sapiens	48-56
9247605-9	1997	TPA-treated THP-1 cells were found to express a vimentin-filament network based on immunocytochemical analysis using an anti-vimentin monoclonal antibody, V9.	Tetradecanoylphorbol Acetate	0-3	vimentin	Homo sapiens	125-133
9099734-0	1997	Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin.	Tetradecanoylphorbol Acetate	115-140	protein tyrosine kinase 2 beta	Homo sapiens	32-70
9150350-10	1997	Vice versa, secretion of macrophage CSF (M-CSF) could be induced by TPA, but not by LPS.	Tetradecanoylphorbol Acetate	68-71	colony stimulating factor 2	Homo sapiens	36-39
9150350-10	1997	Vice versa, secretion of macrophage CSF (M-CSF) could be induced by TPA, but not by LPS.	Tetradecanoylphorbol Acetate	68-71	colony stimulating factor 1	Homo sapiens	41-46
9110154-3	1997	By using a specific and sensitive ELISA, we found that the spontaneous production of M-CSF by human marrow stromal cells is enhanced after stimulation with lipopolysaccharide (LPS), phorbol myristic acetate (PMA) and most interestingly by the lipidic mediator of inflammation platelet-activating factor (PAF).	Tetradecanoylphorbol Acetate	208-211	colony stimulating factor 1	Homo sapiens	85-90
9085940-3	1997	Treatment of dermal papilla cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited the rapid and transient production of mature (17 kDa) cytosolic IL-1beta protein, but not IL-1alpha, with maximal levels achieved after 12 h. Rapid secretion of IL-1beta into the medium occurred subsequent to increased intracellular cytokine levels, after which medium IL-1beta protein levels were stable for 4 days.	Tetradecanoylphorbol Acetate	77-80	interleukin 1 alpha	Homo sapiens	181-190
9101425-2	1997	Stabilization of LDLR mRNA in response to PMA was also observed in HH01 cells, a human hepatocyte coculture system derived from normal human liver.	Tetradecanoylphorbol Acetate	42-45	low density lipoprotein receptor	Homo sapiens	17-21
9042336-6	1997	The effect of PAF on c-fos gene expression was not prevented by pre incubation with the PTK inhibitors genistein or methyl-2,5-dihydroxycinnamate, whereas was strongly affected by PKC down regulation after long term incubation with PMA or by PKC inhibition with sangivamycin.	Tetradecanoylphorbol Acetate	232-235	PCNA clamp associated factor	Homo sapiens	14-17
9028336-10	1997	However, PMA significantly inhibited the in situ tyrosine phosphorylation and the activation of lyn observed in response to GM-CSF.	Tetradecanoylphorbol Acetate	9-12	colony stimulating factor 2	Homo sapiens	124-130
9040941-6	1997	Because WASP also binds to Ash/Grb2 SH3 domains and the association of Ash/Grb2 and Shc is induced by 12-O-tetradecanoylphorbol 13-acetate treatment, a signaling pathway, PKC-tyrosine kinase-Shc-Ash/Grb2-WASP, is suggested for regulating megakaryocyte differentiation.	Tetradecanoylphorbol Acetate	102-138	WASP actin nucleation promoting factor	Homo sapiens	8-12
9040941-6	1997	Because WASP also binds to Ash/Grb2 SH3 domains and the association of Ash/Grb2 and Shc is induced by 12-O-tetradecanoylphorbol 13-acetate treatment, a signaling pathway, PKC-tyrosine kinase-Shc-Ash/Grb2-WASP, is suggested for regulating megakaryocyte differentiation.	Tetradecanoylphorbol Acetate	102-138	WASP actin nucleation promoting factor	Homo sapiens	204-208
9052740-0	1997	Apoptosis through CD95 (Fas/APO-1), but not a CD40/CD95 chimeric receptor, is inhibited by phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	91-122	Fas cell surface death receptor	Homo sapiens	18-22
9052740-0	1997	Apoptosis through CD95 (Fas/APO-1), but not a CD40/CD95 chimeric receptor, is inhibited by phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	91-122	Fas cell surface death receptor	Homo sapiens	28-33
8999958-8	1997	Furthermore, both 12-O-tetradecanoylphorbol 13-acetate and a nonspecific kinase inhibitor, staurosporine, prevented ceramide-induced apoptosis by inhibiting cytosolic translocation of PKC-delta and -epsilon.	Tetradecanoylphorbol Acetate	18-54	protein kinase C epsilon	Homo sapiens	184-206
9030717-6	1997	The time course of uPA-catalyzed cleavage of cell-bound uPAR was studied using U937 cells stimulated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	106-137	plasminogen activator, urokinase receptor	Homo sapiens	56-60
8995230-4	1997	TPA treatment of L epsilon delta, cells that overexpressed the PKC-epsilon delta chimera, induced a dramatically increased cell volume, surface adherence, surface expression of Mac-1 and Mac-3, lysozyme production, and phagocytosis.	Tetradecanoylphorbol Acetate	0-3	lysosomal-associated membrane protein 2	Mus musculus	187-192
9547538-0	1997	Cloning and sequencing of prostaglandin H synthetase from rat tracheal epithelial cells: structural evidence that a TPA regulated mRNA codes for the rat ortholog of murine PHS-1.	Tetradecanoylphorbol Acetate	116-119	prostaglandin-endoperoxide synthase 1	Mus musculus	172-177
9547543-0	1997	Induction of prostaglandin endoperoxide synthase-1 (COX-1) in a human promonocytic cell line by treatment with the differentiating agent TPA.	Tetradecanoylphorbol Acetate	137-140	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	52-57
8898893-2	1996	The PAI-2 gene is one of the most TNF-responsive genes known and is also highly induced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the phosphatase inhibitor, okadaic acid, in both HT-1080 fibrosarcoma and U-937 histiocytic cells.	Tetradecanoylphorbol Acetate	109-140	serpin family B member 2	Homo sapiens	4-9
8898893-2	1996	The PAI-2 gene is one of the most TNF-responsive genes known and is also highly induced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the phosphatase inhibitor, okadaic acid, in both HT-1080 fibrosarcoma and U-937 histiocytic cells.	Tetradecanoylphorbol Acetate	142-145	serpin family B member 2	Homo sapiens	4-9
8890955-8	1996	In A5 cells, stimulation with factors that activate the serum-response element on the fos promoter and induce c-fos mRNA had little effect on AP-1 activity, whereas treatment with 12-O-tetradecanoylphorbol-13-acetate, which acts at the fos-AP-1 binding sequence site on the fos promoter, efficiently induced c-fos mRNA.	Tetradecanoylphorbol Acetate	180-216	FBJ osteosarcoma oncogene	Mus musculus	308-313
8798386-3	1996	Activation of ERK2 by the 5-HT1A receptor-selective agonist 8-hydroxy-N,N-dipropyl-2-aminotetralin hydrobromide (8-OH-DPAT) was inhibited completely by pertussis toxin and substantially by prolonged treatment of cells with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	223-254	5-hydroxytryptamine receptor 1A	Homo sapiens	26-41
19710363-8	2009	Overexpression of a portion of AHNAK1 resulted in augmentation of intracellular calcium mobilization, whereas siRNA-mediated knockdown of NPR-C or AHNAK1 protein resulted in attenuation of intracellular calcium mobilization in response to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	239-270	natriuretic peptide receptor 3	Homo sapiens	138-143
19843787-15	2009	Prolonged (24 h) pretreatment with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate before OGD significantly reversed the effect of propofol on AQP4 expression (P &lt; 0.01).	Tetradecanoylphorbol Acetate	54-90	aquaporin 4	Rattus norvegicus	151-155
19591805-3	2009	B1 and B2, inhibited tumor necrosis factor alpha (TNFalpha)- and phorbol 12-myristate 13-acetate (PMA)-induced transactivation of NF-kappaB-driven genes and the increase of NF-kappaB-DNA nuclear binding in Jurkat T cells.	Tetradecanoylphorbol Acetate	98-101	membrane spanning 4-domains A1	Homo sapiens	0-9
19787254-4	2009	Hepatoma cell lines (HepG2 and PLC/PRF/5) were induced EFC or epithelial-mesenchymal transition (EMT) by phorbol 12-myristate 13 acetate (TPA) or transforming growth factor (TGF)-beta1.	Tetradecanoylphorbol Acetate	105-136	heparan sulfate proteoglycan 2	Homo sapiens	31-34
9012782-5	1997	The egr-1 gene elevation was not blocked by prior exposure to indomethacin, saralasin, Rp-cAMP, A23187, and colchicine, and it was blocked partially by cytochalasin D, H-7, and prolonged exposure to TPA.	Tetradecanoylphorbol Acetate	199-202	early growth response 1	Mus musculus	4-9
9591190-4	1997	It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU).	Tetradecanoylphorbol Acetate	16-52	FBJ osteosarcoma oncogene	Mus musculus	206-211
9591190-4	1997	It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU).	Tetradecanoylphorbol Acetate	54-57	FBJ osteosarcoma oncogene	Mus musculus	206-211
19841537-2	2009	The annexin A2 complex (termed "A2") is the cell surface coreceptor for plasminogen and TPA and accelerates the catalytic activation of plasmin, the major fibrinolytic agent in mammals.	Tetradecanoylphorbol Acetate	88-91	annexin A2	Mus musculus	4-14
8985203-4	1997	STZ and phorbol myristate acetate, but not LPS, FMLP, or LTA, stimulated isolated PMNL to release BPI.	Tetradecanoylphorbol Acetate	8-33	bactericidal permeability increasing protein	Homo sapiens	98-101
19740314-4	2009	This report confirms, using IL-32 small interfering RNA, that IL-32beta induces an anti-inflammatory cytokine IL-10 in K562-IL-32beta cells and U937 promonocytic cells, which express endogenous IL-32beta upon phorbol 12-myristate 13-acetate (PMA) treatment, and monocyte-derived dendritic cells (DC) upon lipopolysaccharide (LPS) treatment.	Tetradecanoylphorbol Acetate	209-240	interleukin 32	Homo sapiens	62-71
8988173-5	1997	In a search for cellular factors that could activate p21 during phorbol ester (TPA)-induced differentiation, we identified AP2 as a regulator of p21 expression.	Tetradecanoylphorbol Acetate	79-82	H3 histone pseudogene 16	Homo sapiens	53-56
8988173-5	1997	In a search for cellular factors that could activate p21 during phorbol ester (TPA)-induced differentiation, we identified AP2 as a regulator of p21 expression.	Tetradecanoylphorbol Acetate	79-82	H3 histone pseudogene 16	Homo sapiens	145-148
19740314-4	2009	This report confirms, using IL-32 small interfering RNA, that IL-32beta induces an anti-inflammatory cytokine IL-10 in K562-IL-32beta cells and U937 promonocytic cells, which express endogenous IL-32beta upon phorbol 12-myristate 13-acetate (PMA) treatment, and monocyte-derived dendritic cells (DC) upon lipopolysaccharide (LPS) treatment.	Tetradecanoylphorbol Acetate	242-245	interleukin 32	Homo sapiens	62-71
8988173-6	1997	Mutagenesis of an AP2 DNA-binding site within a p21 promoter-luciferase reporter inhibited its activation by either AP2 transfection or TPA stimulation.	Tetradecanoylphorbol Acetate	136-139	H3 histone pseudogene 16	Homo sapiens	48-51
19661812-5	2009	Celastrol also inhibits thrombin-stimulated and phorbol 12-myristate 13-acetate-stimulated P-selectin expression on platelets.	Tetradecanoylphorbol Acetate	48-79	selectin P	Homo sapiens	91-101
11173634-2	1997	Previously, we have shown, that PMA pretreatment reduced etoposide-(ETO) but enhanced staurosporine- (STA) -induced apoptosis in HT58 cells.	Tetradecanoylphorbol Acetate	32-35	GCY	Homo sapiens	86-106
11173634-4	1997	The sensitivity of HT58 cells to ETO- or STA-induced apoptosis is influenced diversely with PMA pre- or posttreatment.	Tetradecanoylphorbol Acetate	92-95	GCY	Homo sapiens	41-44
19639210-4	2009	VK2 inhibited the basal and TPA-induced expression of MMP-1, -3 and -7 at the transcriptional, mRNA and protein levels in a dose-dependent manner.	Tetradecanoylphorbol Acetate	28-31	matrix metallopeptidase 1	Homo sapiens	54-70
16793673-0	1997	PMA induces platelet activation of specific antigens (CD62/CD63) in GpIIb-IIIa deficient platelets from Glanzmann"s thrombasthenia.	Tetradecanoylphorbol Acetate	0-3	selectin P	Homo sapiens	54-58
16793673-0	1997	PMA induces platelet activation of specific antigens (CD62/CD63) in GpIIb-IIIa deficient platelets from Glanzmann"s thrombasthenia.	Tetradecanoylphorbol Acetate	0-3	CD63 molecule	Homo sapiens	59-63
8989917-6	1996	Suppression of TPA (100 ng/mL)-induced c-jun and c-fos gene expression was also observed in the mouse fibroblast cells pretreated with crocetin (30, 60, and 120 microM).	Tetradecanoylphorbol Acetate	15-18	FBJ osteosarcoma oncogene	Mus musculus	49-54
8912844-4	1996	Estrogen-dependent MCF-7 cells exhibited a relatively high expression of COX-1; COX-2 was barely detectable but was transiently induced by treatment with TPA (10 nM).	Tetradecanoylphorbol Acetate	154-157	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	73-78
19639210-6	2009	The inhibitors against NF-kappaB and mitogen-activated protein kinases (MAP kinase) including ERK and JNK pathways suppressed TPA-induced luciferase activity of MMP-1, -3 and -7 promoters.	Tetradecanoylphorbol Acetate	126-129	matrix metallopeptidase 1	Homo sapiens	161-177
19420016-5	2009	Using specific inhibitors, we confirmed that PMA-induced cell invasion and MMP-9 expression is primarily regulated by nuclear factor-kappa B (NF-kappaB) activation via phosphatidylinositol 3-kinase (PI3K)/Akt and activator protein-1 (AP-1) activation via extracellular signal-regulated kinase (ERK)1/2.	Tetradecanoylphorbol Acetate	45-48	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	168-197
8906745-4	1996	Our work demonstrates that: (1) resting B cells from mice containing the Yaa allele hyperproliferated compared to that seen with B cells from mice lacking the Yaa allele, (2) this hyperproliferation occurred whether cells were stimulated with phorbol myristate acetate/ionomycin, LPS, anti-IgM, or CD40L cross-linking, (3) this hyperproliferation is specific to B and not T cells.	Tetradecanoylphorbol Acetate	243-268	CD40 ligand	Mus musculus	298-303
19279008-1	2009	Activation of protein kinase C (PKC) by the phorbol ester (phorbol 12-myristate 13-acetate) induces ceramide formation through the salvage pathway involving, in part, acid beta-glucosidase 1 (GBA1), which cleaves glucosylceramide to ceramide.	Tetradecanoylphorbol Acetate	59-90	glucosylceramidase beta	Homo sapiens	192-196
8863518-6	1996	Substance P, cholecystokinin, neurotensin, and brain natriuretic peptide also increased the level of expression along with phorbol 12-myristate 13-acetate and dibutyrylcyclic GMP, whereas forskolin and dibutyryl-cyclic AMP caused a decrease.	Tetradecanoylphorbol Acetate	123-154	tachykinin 1	Mus musculus	0-11
19244478-6	2009	On the contrary, SERCA2 expression is reduced, despite high CN activity, following protein kinase C (PKC) activation by PE (or phorbol 12-myristate 13-acetate) under conditions producing myocyte hypertrophy.	Tetradecanoylphorbol Acetate	127-158	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	17-23
8930166-2	1996	The following agents inhibited phorbol 12-myristate 13-acetate-stimulated O2- generation significantly in the all-trans retinoic acid-treated HL-60 cells (expressed as percentage of control, P &lt; .05): 1) PKC inhibitors: staurosporine (100 nM, 3 +/- 1%); Ro 31-8220 (1 microM, 3 +/- 2%); sphingosine (100 microM, 15 +/- 7%); 2) PSP 1 and 2a inhibitors, okadaic acid (10 microM, 35 +/- 1%); calyculin A (10 microM, 73 +/- 1%); 3) MAPK inhibitor: SB-203580 (100 microM, 62 +/- 1%); 4) PTP inhibitors: phenylarsine oxide (1 microM, 12 +/- 9%); diamide (1 mM, 21 +/- 11%); and 5) secretory phospholipase A2 inhibitors: manoalide (1 microM, 24 +/- 10%); scalaradial (1 microM, 11 +/- 4%).	Tetradecanoylphorbol Acetate	31-62	paraspeckle component 1	Homo sapiens	330-342
8947596-6	1996	However, the T cells of B10 mice produced high levels of IL-2 and IL-4 when stimulated by phorbol myristate acetate (PMA) and Ca2+ ionophore, proving the existence of a functionally intact signal transduction pathway downstream of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	90-115	interleukin 2	Mus musculus	57-61
8947596-6	1996	However, the T cells of B10 mice produced high levels of IL-2 and IL-4 when stimulated by phorbol myristate acetate (PMA) and Ca2+ ionophore, proving the existence of a functionally intact signal transduction pathway downstream of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	90-115	interleukin 4	Mus musculus	66-70
8912706-0	1996	Phorbol 12-myristate 13-acetate inhibits epidermal growth factor signalling in human keratinocytes, leading to decreased ornithine decarboxylase activity.	Tetradecanoylphorbol Acetate	0-31	epidermal growth factor	Homo sapiens	41-64
8912706-8	1996	To explore the mechanism whereby PMA interfered with EGF signalling, the effect of PMA on EGF binding to its cell-surface receptor was studied; acute treatment with PMA (within 7 h) decreased EGF binding to 41-57% of the baseline level.	Tetradecanoylphorbol Acetate	33-36	epidermal growth factor	Homo sapiens	53-56
8912706-12	1996	Additionally, PMA inhibited the induction of ODC by EGF through decreased EGF binding, possibly mediated by PKC activation.	Tetradecanoylphorbol Acetate	14-17	epidermal growth factor	Homo sapiens	52-55
19388146-0	2009	Expression of CD147 on phorbol-12-myristate-13-acetate (PMA)-treated U937 cells differentiating into foam cells.	Tetradecanoylphorbol Acetate	23-54	basigin (Ok blood group)	Homo sapiens	14-19
8912706-12	1996	Additionally, PMA inhibited the induction of ODC by EGF through decreased EGF binding, possibly mediated by PKC activation.	Tetradecanoylphorbol Acetate	14-17	epidermal growth factor	Homo sapiens	74-77
8913498-0	1996	Translational augmentation of pro-matrix metalloproteinase 3 (prostromelysin 1) and a tissue inhibitor of metalloproteinases (TIMP)-1 mRNAs by epidermal growth factor and transforming growth factor alpha, but not by interleukin 1 alpha or 12-O-tetradecanoylphorbol 13-acetate in human uterine cervical fibroblasts: the possible involvement of an atypical protein kinase C. We have previously reported that epidermal growth factor (EGF) augments the translation of pro-matrix metalloproteinase 3 (proMMP-3/prostromelysin 1) and tissue inhibitor of metalloproteinases (TIMP)-1 mRNAs during the first 1-h treatment of human uterine cervical fibroblasts (Hosono, T. et al., FEBS Lett., 381, 115-118, (1996)).	Tetradecanoylphorbol Acetate	239-275	epidermal growth factor	Homo sapiens	143-166
19388146-0	2009	Expression of CD147 on phorbol-12-myristate-13-acetate (PMA)-treated U937 cells differentiating into foam cells.	Tetradecanoylphorbol Acetate	56-59	basigin (Ok blood group)	Homo sapiens	14-19
19333010-6	2009	The increase in KLF6 by PMA was associated with upregulation of the cyclin-dependent kinase inhibitors (CDKIs) p21(WAF1/CIP1) and p27(KIP1).	Tetradecanoylphorbol Acetate	24-27	interferon alpha inducible protein 27	Homo sapiens	130-133
21541584-10	1996	TPA was present in the majority of the seminomatous and nonseminomatous GCTs, and was significantly higher in ECs and YSTs than in seminomas, MTs, and IMTs (Ki-67, P=0.0001; PCNA, P=0.0006).	Tetradecanoylphorbol Acetate	0-3	proliferating cell nuclear antigen	Homo sapiens	174-178
19333010-6	2009	The increase in KLF6 by PMA was associated with upregulation of the cyclin-dependent kinase inhibitors (CDKIs) p21(WAF1/CIP1) and p27(KIP1).	Tetradecanoylphorbol Acetate	24-27	cyclin dependent kinase inhibitor 1B	Homo sapiens	134-138
8923515-4	1996	The proENK mRNA level began to increase within an hour, then reached and remained at a peak 3-12 h after stimulation by both forskolin and PMA.	Tetradecanoylphorbol Acetate	139-142	proenkephalin	Rattus norvegicus	4-10
19483400-0	2009	Secretory dynamics of tPA and its modulation by PAI-1 in vascular system.	Tetradecanoylphorbol Acetate	22-25	serpin family E member 1	Homo sapiens	48-53
8923515-5	1996	The increased proENK mRNA level in forskolin-treated cells was slightly decreased 24 h after the stimulation, whereas the level of proENK mRNA returned to basal levels in PMA-treated cells.	Tetradecanoylphorbol Acetate	171-174	proenkephalin	Rattus norvegicus	131-137
8923515-11	1996	Calcium influx through both L- and N-type calcium channels, calmodulin and Ca2+/calmodulin-dependent protein kinase II appear to be involved in the increase of proENK mRNA levels induced by either forskolin or PMA.	Tetradecanoylphorbol Acetate	210-213	proenkephalin	Rattus norvegicus	160-166
19338776-7	2009	Runx3 inhibited IL-4 production in EL-4 T cells stimulated with PMA/ionomycin.	Tetradecanoylphorbol Acetate	64-67	interleukin 4	Mus musculus	16-20
8853338-4	1996	Exposure to PMA for as little as 30 min or for as long as 48 h produced a similar degree of SERCA2 mRNA downregulation over time.	Tetradecanoylphorbol Acetate	12-15	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	92-98
8909987-9	1996	The application of Ca2+ to aortic strips in a Ca(2+)-free solution, that had been treated with 10(-6) M PMA caused concentration-dependent contraction, and the contraction was completely inhibited by IAP.	Tetradecanoylphorbol Acetate	104-107	magnesium transporter 1	Rattus norvegicus	200-203
19414379-2	2009	The effect of TPA was inhibited by inhibitors for PKC and MEK 1/2, but not by those for JNK and p38 MAPK.	Tetradecanoylphorbol Acetate	14-17	mitogen-activated protein kinase kinase 1	Homo sapiens	58-65
19414379-4	2009	These data suggest the possible involvement of MEK1/2 MAPK in the inhibitory effect of TPA on ASNS mRNA expression and that the induction of the down-regulation of ASNS (via MEK1/2 activation) may be a new strategy for the treatment of leukemia blast cells.	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase kinase 1	Homo sapiens	47-53
19331829-9	2009	Our data suggest that the nuclear localization of hnRNP Q might be modified after different treatments, such as: PMA, thapsigargin, arsenite and heat shock.	Tetradecanoylphorbol Acetate	113-116	synaptotagmin binding cytoplasmic RNA interacting protein	Homo sapiens	50-57
19065636-5	2009	However, phosphorylation of 4E-BP1 and S6K1 on Thr421/Ser424 was significantly decreased in differentiated Dami cells induced by phorbol 12-myristate 13-acetate (PMA), concomitant with increased expression of cyclin D1 and p21 and cyclin D3.	Tetradecanoylphorbol Acetate	129-160	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	28-34
19065636-5	2009	However, phosphorylation of 4E-BP1 and S6K1 on Thr421/Ser424 was significantly decreased in differentiated Dami cells induced by phorbol 12-myristate 13-acetate (PMA), concomitant with increased expression of cyclin D1 and p21 and cyclin D3.	Tetradecanoylphorbol Acetate	129-160	ribosomal protein S6 kinase B1	Homo sapiens	39-43
19065636-5	2009	However, phosphorylation of 4E-BP1 and S6K1 on Thr421/Ser424 was significantly decreased in differentiated Dami cells induced by phorbol 12-myristate 13-acetate (PMA), concomitant with increased expression of cyclin D1 and p21 and cyclin D3.	Tetradecanoylphorbol Acetate	162-165	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	28-34
19195490-4	2009	We also designed a chimera that had an additional N-terminal TPA leader sequence (pTPA.GPI-PA63) with an aim to target GPI-PA63 to ER where new CD1 molecules are synthesized.	Tetradecanoylphorbol Acetate	61-64	protein phosphatase 2 phosphatase activator	Homo sapiens	82-86
19168148-10	2009	When RAW264 cells, murine macrophage cell-line, were stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) or macrophage-colony stimulating factor, the transcription of CTalpha was enhanced accompanied by increased mRNA of Ets2.	Tetradecanoylphorbol Acetate	69-105	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	174-181
19168148-10	2009	When RAW264 cells, murine macrophage cell-line, were stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) or macrophage-colony stimulating factor, the transcription of CTalpha was enhanced accompanied by increased mRNA of Ets2.	Tetradecanoylphorbol Acetate	69-105	E26 avian leukemia oncogene 2, 3' domain	Mus musculus	228-232
19168148-10	2009	When RAW264 cells, murine macrophage cell-line, were stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) or macrophage-colony stimulating factor, the transcription of CTalpha was enhanced accompanied by increased mRNA of Ets2.	Tetradecanoylphorbol Acetate	107-110	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	174-181
19168148-10	2009	When RAW264 cells, murine macrophage cell-line, were stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) or macrophage-colony stimulating factor, the transcription of CTalpha was enhanced accompanied by increased mRNA of Ets2.	Tetradecanoylphorbol Acetate	107-110	E26 avian leukemia oncogene 2, 3' domain	Mus musculus	228-232
19168148-11	2009	These results suggest that the induction of Ets2 is important for CTalpha transcription by TPA and macrophage-colony stimulating factor.	Tetradecanoylphorbol Acetate	91-94	E26 avian leukemia oncogene 2, 3' domain	Mus musculus	44-48
19168148-11	2009	These results suggest that the induction of Ets2 is important for CTalpha transcription by TPA and macrophage-colony stimulating factor.	Tetradecanoylphorbol Acetate	91-94	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	66-73
18997087-9	2009	Hypoxia activated PKCepsilon, whereas phorbol ester (TPA), oxidation (H(2)O(2)), and insulin-like growth factor-1 (IGF-1) activated PKCgamma and decreased the activity of PKCepsilon.	Tetradecanoylphorbol Acetate	53-56	protein kinase C, gamma	Mus musculus	132-140
8887775-4	1996	The PKC activators phorbol 12-myristate 14-acetate (PMA) and phorbol 12, 13-dibutyrate (PDBu) inhibited KIR2.3 currents, but not KIR2.1 or KIR1.1 current.	Tetradecanoylphorbol Acetate	52-55	potassium inwardly rectifying channel subfamily J member 4 S homeolog	Xenopus laevis	104-110
8878412-3	1996	Treatment of MCF-7 cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (100 nM) was associated with a high expression of MMP-1 mRNA, as well as an induction of the level of TIMP-1 mRNA (5- to 10-fold).	Tetradecanoylphorbol Acetate	48-84	matrix metallopeptidase 1	Homo sapiens	141-146
19124542-6	2009	In contrast, the phorbol ester PMA (phorbol-12-myristate-13-acetate, a pharmacological mimic of the downstream mediator diacylglycerol in alpha-adrenergic signalling), caused continuous PKD-dependent HDAC5-GFP nuclear efflux and maintained PKD1-mPlum redistribution.	Tetradecanoylphorbol Acetate	31-34	polycystin 1, transient receptor potential channel interacting	Mus musculus	240-244
8878412-3	1996	Treatment of MCF-7 cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (100 nM) was associated with a high expression of MMP-1 mRNA, as well as an induction of the level of TIMP-1 mRNA (5- to 10-fold).	Tetradecanoylphorbol Acetate	86-89	matrix metallopeptidase 1	Homo sapiens	141-146
19038244-9	2009	Using Western blotting, we demonstrated that andrographolide decreased ERK1 and ERK5 phosphorylation induced by anti-CD3 or PMA/Ionomycin.	Tetradecanoylphorbol Acetate	124-127	mitogen-activated protein kinase 7	Homo sapiens	80-84
8814250-6	1996	Functional helper T cells (Th1 and Th2) were induced from the CD4 lineage-committed cells upon secondary stimulation with a combination of ionomycin and PMA followed by lymphokine treatment.	Tetradecanoylphorbol Acetate	153-156	heart and neural crest derivatives expressed 2	Mus musculus	35-38
19130552-7	2009	The cytoplasmic tails of WC1.1 and WC1.2 were phosphorylated on serine and PKC activity was required for PMA-induced endocytosis of WC1.1 or WC1.2.	Tetradecanoylphorbol Acetate	105-108	antigen WC1.1	Bos taurus	25-30
8906540-4	1996	Brief exposure to a calcium ionophore or phorbol 12-myristate 13-acetate (PMA) stably enhanced PLA2 activity.	Tetradecanoylphorbol Acetate	41-72	phospholipase A2 group IB	Rattus norvegicus	95-99
8906540-4	1996	Brief exposure to a calcium ionophore or phorbol 12-myristate 13-acetate (PMA) stably enhanced PLA2 activity.	Tetradecanoylphorbol Acetate	74-77	phospholipase A2 group IB	Rattus norvegicus	95-99
19130552-7	2009	The cytoplasmic tails of WC1.1 and WC1.2 were phosphorylated on serine and PKC activity was required for PMA-induced endocytosis of WC1.1 or WC1.2.	Tetradecanoylphorbol Acetate	105-108	WC1.2	Bos taurus	35-40
19130552-7	2009	The cytoplasmic tails of WC1.1 and WC1.2 were phosphorylated on serine and PKC activity was required for PMA-induced endocytosis of WC1.1 or WC1.2.	Tetradecanoylphorbol Acetate	105-108	antigen WC1.1	Bos taurus	132-137
8946701-8	1996	The priming effect of rh-GMCSF on superoxide anion production by human MOs stimulated with phorbol myristate acetate (PMA) was both dose-dependent and time-dependent.	Tetradecanoylphorbol Acetate	91-116	colony stimulating factor 2	Homo sapiens	25-30
19130552-7	2009	The cytoplasmic tails of WC1.1 and WC1.2 were phosphorylated on serine and PKC activity was required for PMA-induced endocytosis of WC1.1 or WC1.2.	Tetradecanoylphorbol Acetate	105-108	WC1.2	Bos taurus	141-146
8946701-8	1996	The priming effect of rh-GMCSF on superoxide anion production by human MOs stimulated with phorbol myristate acetate (PMA) was both dose-dependent and time-dependent.	Tetradecanoylphorbol Acetate	118-121	colony stimulating factor 2	Homo sapiens	25-30
8772198-6	1996	By contrast, proMMP-3/prostromelysin 1 is up-regulated by TNFalpha or TPA in the presence of IL-1alpha, whose modulation is PKC-dependent.	Tetradecanoylphorbol Acetate	70-73	interleukin 1 alpha	Homo sapiens	93-102
18977358-10	2009	Moreover antisense inhibition of MARCKS abolished the PMA effect on L-arginine transport.	Tetradecanoylphorbol Acetate	54-57	myristoylated alanine rich protein kinase C substrate	Bos taurus	33-39
18931473-3	2009	In the present study, focusing mainly on PKC epsilon, the mechanisms underlying the proteasome-dependent downregulation of GnRH-activated PKC epsilon and TPA-sensitive PKC alpha and epsilon isoenzymes were investigated in alphaT3-1 gonadotrope cells.	Tetradecanoylphorbol Acetate	154-157	gonadotropin releasing hormone 1	Mus musculus	123-127
18952052-2	2008	While screening for compounds that could block the association of HDAC4 with the BTB domain-containing transcriptional repressor Bach2, we discovered that phorbol 12-myristate 13-acetate (PMA) induced the cytoplasmic retention of HDAC4 mutants lacking a nuclear export signal (NES).	Tetradecanoylphorbol Acetate	155-186	histone deacetylase 4	Homo sapiens	66-71
18952052-2	2008	While screening for compounds that could block the association of HDAC4 with the BTB domain-containing transcriptional repressor Bach2, we discovered that phorbol 12-myristate 13-acetate (PMA) induced the cytoplasmic retention of HDAC4 mutants lacking a nuclear export signal (NES).	Tetradecanoylphorbol Acetate	155-186	histone deacetylase 4	Homo sapiens	230-235
18952052-2	2008	While screening for compounds that could block the association of HDAC4 with the BTB domain-containing transcriptional repressor Bach2, we discovered that phorbol 12-myristate 13-acetate (PMA) induced the cytoplasmic retention of HDAC4 mutants lacking a nuclear export signal (NES).	Tetradecanoylphorbol Acetate	188-191	histone deacetylase 4	Homo sapiens	66-71
18952052-2	2008	While screening for compounds that could block the association of HDAC4 with the BTB domain-containing transcriptional repressor Bach2, we discovered that phorbol 12-myristate 13-acetate (PMA) induced the cytoplasmic retention of HDAC4 mutants lacking a nuclear export signal (NES).	Tetradecanoylphorbol Acetate	188-191	histone deacetylase 4	Homo sapiens	230-235
18929613-8	2008	In addition, we performed experiments with the rat hepatic stellate cell line HSC-T6 in which we induced the expression of MMP-2 and alpha-SMA with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	148-179	actin gamma 2, smooth muscle	Rattus norvegicus	133-142
18929613-8	2008	In addition, we performed experiments with the rat hepatic stellate cell line HSC-T6 in which we induced the expression of MMP-2 and alpha-SMA with phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	181-184	actin gamma 2, smooth muscle	Rattus norvegicus	133-142
19076642-8	2008	These results suggest that PARG gene expression is modulated by PU.1 during TPA-induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	76-79	Spi-1 proto-oncogene	Homo sapiens	64-68
18767048-6	2008	RSVL2 also dose-dependently suppressed MEK1 kinase activity induced by TPA and the inhibition of H-Ras-induced cell transformation was much stronger for RSVL2 than for PD098059 or resveratrol.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase kinase 1	Homo sapiens	39-43
18838072-6	2008	By comparing effects of signalling inhibitors (wortmannin, SH-6, TPA, Go6983, PP2, PD98059) on EGF- and PDGF-induced Erk1/2 activation and cell proliferation (3H-thymidine incorporation), we conclude that while the signal transduction pathways initiated by these growth factors are clearly markedly different, their effects on cell proliferation can be fully explained through their stimulation of Erk1/2 activation; thus Erk1/2 is a common, essential step for stimulation of proliferation in these cells.	Tetradecanoylphorbol Acetate	65-68	epidermal growth factor	Mus musculus	95-98
18952840-3	2008	However, we show here that PMA exposure also induces plasmacytoid dendritic cells (pDCs) in local draining lymph nodes (dLNs) to express indoleamine 2,3 dioxygenase (IDO), which confers T cell suppressor activity on pDCs.	Tetradecanoylphorbol Acetate	27-30	indoleamine 2,3-dioxygenase 1	Mus musculus	137-164
18952840-3	2008	However, we show here that PMA exposure also induces plasmacytoid dendritic cells (pDCs) in local draining lymph nodes (dLNs) to express indoleamine 2,3 dioxygenase (IDO), which confers T cell suppressor activity on pDCs.	Tetradecanoylphorbol Acetate	27-30	indoleamine 2,3-dioxygenase 1	Mus musculus	166-169
18755854-3	2008	MA-10 mouse Leydig tumor cells treated with an activator of PRKCC, phorbol 12-myristate 13-acetate (PMA), demonstrated increases in the expression of the STAR and CYP11A1 proteins and progesterone synthesis, which coincided with the expression and phosphorylation of JUN (P-JUN).	Tetradecanoylphorbol Acetate	67-98	protein kinase C, gamma	Mus musculus	60-65
18755854-3	2008	MA-10 mouse Leydig tumor cells treated with an activator of PRKCC, phorbol 12-myristate 13-acetate (PMA), demonstrated increases in the expression of the STAR and CYP11A1 proteins and progesterone synthesis, which coincided with the expression and phosphorylation of JUN (P-JUN).	Tetradecanoylphorbol Acetate	67-98	steroidogenic acute regulatory protein	Mus musculus	154-158
18755854-3	2008	MA-10 mouse Leydig tumor cells treated with an activator of PRKCC, phorbol 12-myristate 13-acetate (PMA), demonstrated increases in the expression of the STAR and CYP11A1 proteins and progesterone synthesis, which coincided with the expression and phosphorylation of JUN (P-JUN).	Tetradecanoylphorbol Acetate	100-103	protein kinase C, gamma	Mus musculus	60-65
18755854-3	2008	MA-10 mouse Leydig tumor cells treated with an activator of PRKCC, phorbol 12-myristate 13-acetate (PMA), demonstrated increases in the expression of the STAR and CYP11A1 proteins and progesterone synthesis, which coincided with the expression and phosphorylation of JUN (P-JUN).	Tetradecanoylphorbol Acetate	100-103	steroidogenic acute regulatory protein	Mus musculus	154-158
18496814-7	2008	Among various signal inhibitors, the mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor U0126 also inhibited PMA-induced COX-2 expression and COX-2 promoter activation.	Tetradecanoylphorbol Acetate	121-124	mitogen-activated protein kinase kinase 1	Homo sapiens	37-80
18496814-7	2008	Among various signal inhibitors, the mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor U0126 also inhibited PMA-induced COX-2 expression and COX-2 promoter activation.	Tetradecanoylphorbol Acetate	121-124	mitogen-activated protein kinase kinase 1	Homo sapiens	82-88
18827451-3	2008	In the present study, we demonstrate the expression of H4R in human dermal fibroblasts and investigate changes in its expression level when stimulated by histamine, phorbol 12-myristate 13-acetate (PMA), lipopolysaccharides (LPS), dexamethasone and indomethacin.	Tetradecanoylphorbol Acetate	165-196	histamine receptor H4	Homo sapiens	55-58
18827451-3	2008	In the present study, we demonstrate the expression of H4R in human dermal fibroblasts and investigate changes in its expression level when stimulated by histamine, phorbol 12-myristate 13-acetate (PMA), lipopolysaccharides (LPS), dexamethasone and indomethacin.	Tetradecanoylphorbol Acetate	198-201	histamine receptor H4	Homo sapiens	55-58
18768832-8	2008	Specific Abs against Rab27a inhibited Ca(2+) and GTP-gamma-S activation and PMA-induced exocytosis of CD66b-enriched tertiary and specific granules in electropermeabilized neutrophils, whereas secretion of CD63-enriched azurophil granules was scarcely affected.	Tetradecanoylphorbol Acetate	76-79	CD63 molecule	Homo sapiens	206-210
18584879-7	2008	Exocytosis studies showed that isolated neutrophils exposed to several challengers, including Zymosan activated serum (ZAS) and phorbol 12-myristate 13-acetate (PMA), which mimic the inflammatory activation, released PMN-AGP as early as 15min.	Tetradecanoylphorbol Acetate	128-159	alpha-1-acid glycoprotein	Bos taurus	221-224
18584879-7	2008	Exocytosis studies showed that isolated neutrophils exposed to several challengers, including Zymosan activated serum (ZAS) and phorbol 12-myristate 13-acetate (PMA), which mimic the inflammatory activation, released PMN-AGP as early as 15min.	Tetradecanoylphorbol Acetate	161-164	alpha-1-acid glycoprotein	Bos taurus	221-224
18583709-8	2008	Moreover, silencing of cardiomyocyte Hsp25 allowed phorbol 12-myristate 13-acetate to elicit a significant phosphorylation of PKCdelta, an appreciable association between PKCdelta and PKD, and a vigorous activation of PKD.	Tetradecanoylphorbol Acetate	51-82	heat shock protein family B (small) member 1	Homo sapiens	37-42
18602101-3	2008	We find here that morphological activation of endothelial cells by phorbol 12-myristate 13-acetate (PMA) resulted in membrane-type 1 matrix metalloproteinase (MT1-MMP) -mediated solubilization of latent TGF-beta complexes from the ECM by proteolytic processing of LTBP-1.	Tetradecanoylphorbol Acetate	67-98	latent transforming growth factor beta binding protein 1	Homo sapiens	264-270
18602101-3	2008	We find here that morphological activation of endothelial cells by phorbol 12-myristate 13-acetate (PMA) resulted in membrane-type 1 matrix metalloproteinase (MT1-MMP) -mediated solubilization of latent TGF-beta complexes from the ECM by proteolytic processing of LTBP-1.	Tetradecanoylphorbol Acetate	100-103	latent transforming growth factor beta binding protein 1	Homo sapiens	264-270
18579711-0	2008	TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis.	Tetradecanoylphorbol Acetate	0-3	keratin 14	Mus musculus	58-66
18579711-5	2008	Inflammation was induced in the ear skin with five topical applications of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and a significantly increased inflammation was found in TPA-induced K14/VEGF transgenic animals compared with wild-type mice.	Tetradecanoylphorbol Acetate	175-178	keratin 14	Mus musculus	187-190
18579711-11	2008	In conclusion, the TPA-induced phenotype in K14/VEGF animals displayed several features of psoriasis, including a T(h)17 cytokine profile and a chronic-like progression, and can be used as an in vivo screening model of psoriasis.	Tetradecanoylphorbol Acetate	19-22	keratin 14	Mus musculus	44-47
18534741-4	2008	The following inhibitors: PKCs (bisindolylmaleimide I), PKCepsilon (epsilonV1 peptide) and ERK1/2 (PD98059) prevented the mitogenic activity induced by PMA for 15 min.	Tetradecanoylphorbol Acetate	152-155	protein kinase C epsilon	Homo sapiens	56-66
18534741-5	2008	Lactotroph cells stimulated with PMA for 15 min showed a translocation of PKCepsilon to membrane compartment and nucleus.	Tetradecanoylphorbol Acetate	33-36	protein kinase C epsilon	Homo sapiens	74-84
18435914-3	2008	We have previously shown that two critical elements of Fra-1 promoter, the upstream TPA response element (TRE) and the serum response element (SRE), are necessary for its induction in response to phorbol esters in human pulmonary epithelial cell lines.	Tetradecanoylphorbol Acetate	84-87	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	55-60
18435914-4	2008	Here, we have investigated the roles of various MAP kinases in regulating Fra-1 expression in response to TPA.	Tetradecanoylphorbol Acetate	106-109	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	74-79
18353421-6	2008	Thus, TPA-induced GRS gel shift could be blocked by antibody to Egr-1.	Tetradecanoylphorbol Acetate	6-9	early growth response 1	Homo sapiens	64-69
18353421-7	2008	Further, the TPA-induced GRS DNA/protein complex was isolated and found to contain Egr-1 by Western blot.	Tetradecanoylphorbol Acetate	13-16	early growth response 1	Homo sapiens	83-88
18059331-2	2008	Deletion of the p19/Arf or p53 tumor suppressor genes accelerates malignant progression and metastatic spread of 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced squamous cell carcinomas, providing a model system to address mechanisms of metastasis.	Tetradecanoylphorbol Acetate	151-188	transformation related protein 53, pseudogene	Mus musculus	27-30
18059331-2	2008	Deletion of the p19/Arf or p53 tumor suppressor genes accelerates malignant progression and metastatic spread of 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced squamous cell carcinomas, providing a model system to address mechanisms of metastasis.	Tetradecanoylphorbol Acetate	190-193	transformation related protein 53, pseudogene	Mus musculus	27-30
18072286-3	2008	The 2MeSADP-mediated biphasic Ca(2+) signals were inhibited by phospholipase C (PLC) inhibitor U73122, and completely blocked by P2Y(1) selective antagonist MRS2179 and protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) whereas enhanced by PKC inhibitors GF109203X and Go6979.	Tetradecanoylphorbol Acetate	235-238	purinergic receptor P2Y1	Homo sapiens	129-135
8759717-3	1996	We show here that expression of CD38 is increased in the Jurkat T cell line after treatment with agents that augment intracellular cAMP, with the permeant cAMP analogue dibutyryl-cAMP (db-cAMP), and also with PMA, which activates protein kinase C. Treatment of human PBL T cells with db-cAMP or submitogenic doses of PMA also increased CD38 expression.	Tetradecanoylphorbol Acetate	209-212	CD38 molecule	Homo sapiens	32-36
18326492-2	2008	Arf6-GTP was monitored in platelets stimulated with a number of agonists (TRAP, thrombin, convulxin, collagen, PMA, thapsigargin, or A23187) and all led to a time-dependent decrease in Arf6-GTP.	Tetradecanoylphorbol Acetate	111-114	ADP ribosylation factor 6	Homo sapiens	0-4
8753812-1	1996	The human monocytic leukemic cell line, THP-1, which differentiates toward macrophages in response to phorbol 12-myristate 13-acetate (PMA) was investigated for its ability to produce granulocyte colony-stimulating factor (G-CSF).	Tetradecanoylphorbol Acetate	135-138	colony stimulating factor 3	Homo sapiens	184-221
8753812-2	1996	G-CSF protein was neither produced during PMA-induced differentiation nor in response to retinoic acid (RA) alone.	Tetradecanoylphorbol Acetate	42-45	colony stimulating factor 3	Homo sapiens	0-5
8702551-8	1996	The effect of Mn-SOD overexpression on IL-1alpha expression can be overcome by treatment with the protein kinase C activator, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	126-157	interleukin 1 alpha	Homo sapiens	39-48
8761432-1	1996	Topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal epidermis of Sencar mice induces synthesis of pro-inflammatory cytokines, including interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	23-59	interleukin 1 alpha	Mus musculus	164-183
8761432-1	1996	Topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal epidermis of Sencar mice induces synthesis of pro-inflammatory cytokines, including interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	23-59	interleukin 1 alpha	Mus musculus	185-195
8761432-1	1996	Topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal epidermis of Sencar mice induces synthesis of pro-inflammatory cytokines, including interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	61-64	interleukin 1 alpha	Mus musculus	164-183
18384814-1	2008	miR-21 has been reported to be highly expressed in various cancers and to be inducible in a human promyelocytic cell line, HL-60, after phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	136-167	microRNA 21	Homo sapiens	0-6
8761432-1	1996	Topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal epidermis of Sencar mice induces synthesis of pro-inflammatory cytokines, including interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	61-64	interleukin 1 alpha	Mus musculus	185-195
8761432-5	1996	Intraperitoneal injection of 50 micrograms/g pentoxifylline at 30 min prior to topical application of 10 micrograms TPA to the dorsal epidermis of Sencar mice inhibited TPA-induced IL-1 alpha and TNF-alpha gene expression 24 h after TPA treatment.	Tetradecanoylphorbol Acetate	116-119	interleukin 1 alpha	Mus musculus	181-191
8761432-5	1996	Intraperitoneal injection of 50 micrograms/g pentoxifylline at 30 min prior to topical application of 10 micrograms TPA to the dorsal epidermis of Sencar mice inhibited TPA-induced IL-1 alpha and TNF-alpha gene expression 24 h after TPA treatment.	Tetradecanoylphorbol Acetate	169-172	interleukin 1 alpha	Mus musculus	181-191
8761432-5	1996	Intraperitoneal injection of 50 micrograms/g pentoxifylline at 30 min prior to topical application of 10 micrograms TPA to the dorsal epidermis of Sencar mice inhibited TPA-induced IL-1 alpha and TNF-alpha gene expression 24 h after TPA treatment.	Tetradecanoylphorbol Acetate	169-172	interleukin 1 alpha	Mus musculus	181-191
8663295-1	1996	Desensitization of p21(ras) after stimulation of cells by growth factors and phorbol 12-myristate 13-acetate (PMA) correlates with hyperphosphorylation of the guanine nucleotide exchange factor Son-of-sevenless (Sos) and its dissociation from the adaptor protein Grb2 (Cherniack, A., Klarlund, J. K., Conway, B. R., and Czech, M. P. (1995) J. Biol.	Tetradecanoylphorbol Acetate	77-108	H3 histone pseudogene 16	Homo sapiens	19-22
18384814-1	2008	miR-21 has been reported to be highly expressed in various cancers and to be inducible in a human promyelocytic cell line, HL-60, after phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	169-172	microRNA 21	Homo sapiens	0-6
8663295-1	1996	Desensitization of p21(ras) after stimulation of cells by growth factors and phorbol 12-myristate 13-acetate (PMA) correlates with hyperphosphorylation of the guanine nucleotide exchange factor Son-of-sevenless (Sos) and its dissociation from the adaptor protein Grb2 (Cherniack, A., Klarlund, J. K., Conway, B. R., and Czech, M. P. (1995) J. Biol.	Tetradecanoylphorbol Acetate	110-113	H3 histone pseudogene 16	Homo sapiens	19-22
18435438-3	2008	Phorbol-12-myristic-13-acetate (PMA)-treated THP-1 monocytes differentiated into macrophages and synthesized lipoprotein lipase (LPL), the major enzyme for hydrolysis of triglycerides.	Tetradecanoylphorbol Acetate	32-35	lipoprotein lipase	Homo sapiens	109-127
8704176-3	1996	Activation of the IL-5 promoter required costimulation of T cells with phorbol ester (phorbol 12-myristate 13-acetate [PMA]) and cyclic adenosine 3",5"-monophosphate (cAMP), but was blocked by the immunosuppressive drug, cyclosporin A (CsA).	Tetradecanoylphorbol Acetate	86-117	interleukin 5	Mus musculus	18-22
8704176-3	1996	Activation of the IL-5 promoter required costimulation of T cells with phorbol ester (phorbol 12-myristate 13-acetate [PMA]) and cyclic adenosine 3",5"-monophosphate (cAMP), but was blocked by the immunosuppressive drug, cyclosporin A (CsA).	Tetradecanoylphorbol Acetate	119-122	interleukin 5	Mus musculus	18-22
18435438-3	2008	Phorbol-12-myristic-13-acetate (PMA)-treated THP-1 monocytes differentiated into macrophages and synthesized lipoprotein lipase (LPL), the major enzyme for hydrolysis of triglycerides.	Tetradecanoylphorbol Acetate	32-35	lipoprotein lipase	Homo sapiens	129-132
18335923-5	2008	Compared with the SubPc-TPA dyad, a long-lived charge-separated state was observed for the SubPc-TPA-C(60) triad with the lifetime of the radical ion pairs (tau(RIP)) of 670 ns in benzonitrile.	Tetradecanoylphorbol Acetate	24-27	receptor interacting serine/threonine kinase 1	Homo sapiens	161-164
8668213-6	1996	When expressed in COS cells, however, NFAT1 is capable of transactivation, but it is not regulated correctly: its subcellular localization and transcriptional function are not affected by stimulation of the COS cells with ionomycin and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	236-267	nuclear factor of activated T cells 2	Homo sapiens	38-43
18335923-5	2008	Compared with the SubPc-TPA dyad, a long-lived charge-separated state was observed for the SubPc-TPA-C(60) triad with the lifetime of the radical ion pairs (tau(RIP)) of 670 ns in benzonitrile.	Tetradecanoylphorbol Acetate	97-100	receptor interacting serine/threonine kinase 1	Homo sapiens	161-164
8693290-9	1996	While activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) induces rapid L-selectin down-regulation of L-selectin surface expression in both lymphocytes and granulocytes, the PKC inhibitor, H 7, was also found to down-regulate lymphocyte and granulocyte L-selectin surface expression.	Tetradecanoylphorbol Acetate	46-77	selectin L	Homo sapiens	98-108
8693290-9	1996	While activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) induces rapid L-selectin down-regulation of L-selectin surface expression in both lymphocytes and granulocytes, the PKC inhibitor, H 7, was also found to down-regulate lymphocyte and granulocyte L-selectin surface expression.	Tetradecanoylphorbol Acetate	46-77	selectin L	Homo sapiens	128-138
18335923-6	2008	Interestingly, further charge stabilization was achieved in the charge-separated state of SubPc-TPA-(C(60))(2), in which the tau(RIP) was found to be 1050 ns in benzonitrile.	Tetradecanoylphorbol Acetate	96-99	receptor interacting serine/threonine kinase 1	Homo sapiens	129-132
8693290-9	1996	While activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) induces rapid L-selectin down-regulation of L-selectin surface expression in both lymphocytes and granulocytes, the PKC inhibitor, H 7, was also found to down-regulate lymphocyte and granulocyte L-selectin surface expression.	Tetradecanoylphorbol Acetate	46-77	selectin L	Homo sapiens	128-138
8693290-9	1996	While activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) induces rapid L-selectin down-regulation of L-selectin surface expression in both lymphocytes and granulocytes, the PKC inhibitor, H 7, was also found to down-regulate lymphocyte and granulocyte L-selectin surface expression.	Tetradecanoylphorbol Acetate	79-82	selectin L	Homo sapiens	98-108
18174358-7	2008	However, phorbol 12-myristate 13-acetate-induced inflammation was only partially inhibited by GR-TR, which efficiently repressed IL-1beta and MMP-3 genes while weakly repressing IL-6 and TNF-alpha.	Tetradecanoylphorbol Acetate	9-40	matrix metallopeptidase 3	Mus musculus	142-147
8693290-9	1996	While activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) induces rapid L-selectin down-regulation of L-selectin surface expression in both lymphocytes and granulocytes, the PKC inhibitor, H 7, was also found to down-regulate lymphocyte and granulocyte L-selectin surface expression.	Tetradecanoylphorbol Acetate	79-82	selectin L	Homo sapiens	128-138
8693290-9	1996	While activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) induces rapid L-selectin down-regulation of L-selectin surface expression in both lymphocytes and granulocytes, the PKC inhibitor, H 7, was also found to down-regulate lymphocyte and granulocyte L-selectin surface expression.	Tetradecanoylphorbol Acetate	79-82	selectin L	Homo sapiens	128-138
8662936-8	1996	FGF-2, calf serum, platelet-derived growth factor-BB, and phorbol 12-myristate 13-acetate can also induce FR-19 mRNA levels.	Tetradecanoylphorbol Acetate	58-89	TEA domain family member 4	Mus musculus	106-111
18223295-10	2008	Induction of differentiation of thymocytes with phorbol 12-myristate 13-acetate plus ionomycin results in transcriptional repression of TdT expression.	Tetradecanoylphorbol Acetate	48-79	deoxynucleotidyltransferase, terminal	Mus musculus	136-139
8780891-8	1996	A high concentration of TPA (1.6 microM) down regulated PKC-alpha and PKC-beta I almost completely and PKC-epsilon partially in wild-type SH-SY5Y and SH-SY5Y/trk cells.	Tetradecanoylphorbol Acetate	24-27	protein kinase C epsilon	Homo sapiens	103-114
8780891-11	1996	The 1.6 microM TPA-induced down-regulation of PKC-epsilon was counteracted by bFGF and NGF but not by platelet-derived growth factor or IGF-I.	Tetradecanoylphorbol Acetate	15-18	protein kinase C epsilon	Homo sapiens	46-57
18282472-4	2008	However, caspase-9/-3-mediated cytotoxicity can be induced in TPA-differentiated cells if they are pretreated with a protein kinase C (PKC) or a mitogen activated protein kinase (MEK) inhibitor.	Tetradecanoylphorbol Acetate	62-65	caspase 9	Homo sapiens	9-18
8842529-5	1996	The release of [14C]-dihomo-gamma-linolenic acid (DHGLA), predominately bound to the 2-positions of phospholipids, was also stimulated by 8 h of TPA treatment but not by 24 h of EGF treatment.	Tetradecanoylphorbol Acetate	145-148	epidermal growth factor	Mus musculus	178-181
8645989-7	1996	High doses of PAF or phorbol myristate acetate (PMA) downregulated neutrophils and a low dose PAF decreased the specific [3H]PAF binding to eosinophils determined with WEB 2086 at 20 degrees C. Only neutrophils were significantly upregulated by low dose PAF (5 nM), lyso PAF or low dose PMA (1 nM).	Tetradecanoylphorbol Acetate	21-46	PCNA clamp associated factor	Homo sapiens	94-97
18282472-5	2008	Taken together, this study demonstrates that TPA-differentiated HL-60 cells inhibit caspases-9/-3-mediated cytotoxicity through the PKC and MEK signaling pathways.	Tetradecanoylphorbol Acetate	45-48	caspase 9	Homo sapiens	84-92
8645989-7	1996	High doses of PAF or phorbol myristate acetate (PMA) downregulated neutrophils and a low dose PAF decreased the specific [3H]PAF binding to eosinophils determined with WEB 2086 at 20 degrees C. Only neutrophils were significantly upregulated by low dose PAF (5 nM), lyso PAF or low dose PMA (1 nM).	Tetradecanoylphorbol Acetate	21-46	PCNA clamp associated factor	Homo sapiens	94-97
8645989-7	1996	High doses of PAF or phorbol myristate acetate (PMA) downregulated neutrophils and a low dose PAF decreased the specific [3H]PAF binding to eosinophils determined with WEB 2086 at 20 degrees C. Only neutrophils were significantly upregulated by low dose PAF (5 nM), lyso PAF or low dose PMA (1 nM).	Tetradecanoylphorbol Acetate	21-46	PCNA clamp associated factor	Homo sapiens	94-97
8645989-7	1996	High doses of PAF or phorbol myristate acetate (PMA) downregulated neutrophils and a low dose PAF decreased the specific [3H]PAF binding to eosinophils determined with WEB 2086 at 20 degrees C. Only neutrophils were significantly upregulated by low dose PAF (5 nM), lyso PAF or low dose PMA (1 nM).	Tetradecanoylphorbol Acetate	21-46	PCNA clamp associated factor	Homo sapiens	94-97
18184742-3	2008	Treatment with 12-O-tetradecanoylphorbol-13-acetate increased Lamc1 mRNA in rat mesangial cells (RMC).	Tetradecanoylphorbol Acetate	15-51	laminin subunit gamma 1	Rattus norvegicus	62-67
8645989-7	1996	High doses of PAF or phorbol myristate acetate (PMA) downregulated neutrophils and a low dose PAF decreased the specific [3H]PAF binding to eosinophils determined with WEB 2086 at 20 degrees C. Only neutrophils were significantly upregulated by low dose PAF (5 nM), lyso PAF or low dose PMA (1 nM).	Tetradecanoylphorbol Acetate	287-290	PCNA clamp associated factor	Homo sapiens	14-17
8645989-7	1996	High doses of PAF or phorbol myristate acetate (PMA) downregulated neutrophils and a low dose PAF decreased the specific [3H]PAF binding to eosinophils determined with WEB 2086 at 20 degrees C. Only neutrophils were significantly upregulated by low dose PAF (5 nM), lyso PAF or low dose PMA (1 nM).	Tetradecanoylphorbol Acetate	287-290	PCNA clamp associated factor	Homo sapiens	94-97
8645989-7	1996	High doses of PAF or phorbol myristate acetate (PMA) downregulated neutrophils and a low dose PAF decreased the specific [3H]PAF binding to eosinophils determined with WEB 2086 at 20 degrees C. Only neutrophils were significantly upregulated by low dose PAF (5 nM), lyso PAF or low dose PMA (1 nM).	Tetradecanoylphorbol Acetate	287-290	PCNA clamp associated factor	Homo sapiens	94-97
8645989-7	1996	High doses of PAF or phorbol myristate acetate (PMA) downregulated neutrophils and a low dose PAF decreased the specific [3H]PAF binding to eosinophils determined with WEB 2086 at 20 degrees C. Only neutrophils were significantly upregulated by low dose PAF (5 nM), lyso PAF or low dose PMA (1 nM).	Tetradecanoylphorbol Acetate	287-290	PCNA clamp associated factor	Homo sapiens	94-97
8645989-7	1996	High doses of PAF or phorbol myristate acetate (PMA) downregulated neutrophils and a low dose PAF decreased the specific [3H]PAF binding to eosinophils determined with WEB 2086 at 20 degrees C. Only neutrophils were significantly upregulated by low dose PAF (5 nM), lyso PAF or low dose PMA (1 nM).	Tetradecanoylphorbol Acetate	287-290	PCNA clamp associated factor	Homo sapiens	94-97
18084041-8	2008	Phorbol myristate acetate (PMA) induced the accumulation of DRAK2 in the cytoplasm of NIH3T3 cells, whereas in the absence of PMA, DRAK2 was localized to the nucleus.	Tetradecanoylphorbol Acetate	0-25	serine/threonine kinase 17b (apoptosis-inducing)	Mus musculus	60-65
8761946-0	1996	Phorbol myristate acetate transactivates the avian beta 3 integrin gene and induces alpha v beta 3 integrin expression.	Tetradecanoylphorbol Acetate	0-25	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	51-57
8761290-8	1996	In addition, TPA-treated cells showed high levels of cyclin B and cdc2 proteins, however no activation of cdc2 was detected.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase 1	Homo sapiens	66-70
8663337-6	1996	Whereas the calcium-ionophore A23187 did not affect LPL gene expression, treatment with phorbol 12-myristate 13-acetate decreased LPL mRNA levels in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	88-119	lipoprotein lipase	Homo sapiens	130-133
8761946-0	1996	Phorbol myristate acetate transactivates the avian beta 3 integrin gene and induces alpha v beta 3 integrin expression.	Tetradecanoylphorbol Acetate	0-25	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	92-98
18084041-8	2008	Phorbol myristate acetate (PMA) induced the accumulation of DRAK2 in the cytoplasm of NIH3T3 cells, whereas in the absence of PMA, DRAK2 was localized to the nucleus.	Tetradecanoylphorbol Acetate	27-30	serine/threonine kinase 17b (apoptosis-inducing)	Mus musculus	60-65
8663337-7	1996	This decrease after phorbol 12-myristate 13-acetate was associated with diminished heparin-releasable LPL mass and activity in the culture medium.	Tetradecanoylphorbol Acetate	20-51	lipoprotein lipase	Homo sapiens	102-105
18288394-9	2008	Thus, the up-regulation of BTG2 genes may be involved in the differentiation process of HL-60 cells after TPA or RA treatment.	Tetradecanoylphorbol Acetate	106-109	BTG anti-proliferation factor 2	Homo sapiens	27-31
8683202-2	1996	Unspliced, 3" co-terminal transcripts of 0.8 and 1.6 kb from O-tetradecanoylphorbol 13-acetate (TPA)-treated B95-8 cells have been described but other results indicated the existence of uncharacterized transcript(s) initiated upstream of the 1.6 kb BCRF1 mRNA.	Tetradecanoylphorbol Acetate	96-99	protein UL87	Human gammaherpesvirus 4	249-254
8648726-3	1996	Previous work identified four related elements (ZIA, ZIB, ZIC, and ZID) and a cyclic AMP response element binding-AP-1 element (ZII) that are involved in the induction of the BZLF1 promoter (Zp) by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (E. Flemington and S. H. Speck, J. Virol.	Tetradecanoylphorbol Acetate	216-252	protein Zta	Human gammaherpesvirus 4	175-180
17924856-10	2008	PMA treatment appears to induce translocation of HuR from the nucleus to the cytoplasm.	Tetradecanoylphorbol Acetate	0-3	ELAV like RNA binding protein 1	Homo sapiens	49-52
8648726-3	1996	Previous work identified four related elements (ZIA, ZIB, ZIC, and ZID) and a cyclic AMP response element binding-AP-1 element (ZII) that are involved in the induction of the BZLF1 promoter (Zp) by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (E. Flemington and S. H. Speck, J. Virol.	Tetradecanoylphorbol Acetate	254-257	protein Zta	Human gammaherpesvirus 4	175-180
8658534-13	1996	Taken together, VT enhanced and/or delayed peak IL-2, IL-4, and IL-5 gene expression and secretion in CD4+ T cells stimulated with PMA and ionomycin.	Tetradecanoylphorbol Acetate	131-134	interleukin 5	Mus musculus	64-68
17180098-4	1996	Stimulation of T cells by treatment with PMA and ionomycine (P/I) lead up to a 100-fold maximal increase in CD95-L mRNA after 4 h. CD95-L mRNA is produced by activated CD8 and CD4T cells.	Tetradecanoylphorbol Acetate	41-44	Fas ligand	Homo sapiens	108-114
17180098-4	1996	Stimulation of T cells by treatment with PMA and ionomycine (P/I) lead up to a 100-fold maximal increase in CD95-L mRNA after 4 h. CD95-L mRNA is produced by activated CD8 and CD4T cells.	Tetradecanoylphorbol Acetate	41-44	Fas ligand	Homo sapiens	131-137
8668212-5	1996	Deactivation of NFAT1 is facilitated by phorbol 12-myristate 13-acetate and inhibitors of capacitative calcium entry and most likely reflects the slow return of intracellular free calcium concentrations towards resting levels.	Tetradecanoylphorbol Acetate	40-71	nuclear factor of activated T cells 2	Homo sapiens	16-21
8668213-4	1996	Transactivation by recombinant NFAT1 in Jurkat T cells requires dual stimulation with ionomycin and phorbol 12-myristate 13-acetate; this activity is potentiated by coexpression of constitutively active calcineurin and is inhibited by CsA.	Tetradecanoylphorbol Acetate	100-131	nuclear factor of activated T cells 2	Homo sapiens	31-36
8662898-9	1996	C-ANP also strongly inhibited the endothelin-3-, platelet-derived growth factor-, and phorbol 12-myristate 13-acetate-induced stimulation of DNA synthesis in the astrocytes, while both okadaic acid and sodium vanadate significantly reversed these anti-proliferative actions.	Tetradecanoylphorbol Acetate	86-117	calpain 1	Homo sapiens	0-5
8662742-6	1996	Likewise, an inhibition of phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced interleukin 2 (IL-2) protein secretion, which correlated to decreased IL-2 gene transcription, was induced by both cannabinol and Delta9-THC.	Tetradecanoylphorbol Acetate	27-58	interleukin 2	Mus musculus	83-96
8662742-6	1996	Likewise, an inhibition of phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced interleukin 2 (IL-2) protein secretion, which correlated to decreased IL-2 gene transcription, was induced by both cannabinol and Delta9-THC.	Tetradecanoylphorbol Acetate	27-58	interleukin 2	Mus musculus	98-102
8662742-6	1996	Likewise, an inhibition of phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced interleukin 2 (IL-2) protein secretion, which correlated to decreased IL-2 gene transcription, was induced by both cannabinol and Delta9-THC.	Tetradecanoylphorbol Acetate	27-58	interleukin 2	Mus musculus	153-157
18070609-2	2008	Here, it is shown that the proinflammatory mediator lipopolysaccharide (LPS) inhibits the induction of Prx I expression and promoter activity by the phorbol ester 12-O-tetradecanoylphorbol- 13-acetate (TPA) in RAW264.7 monocytes, but not that of cyclooxygenase-2.	Tetradecanoylphorbol Acetate	163-200	peroxiredoxin 1	Homo sapiens	103-108
8662742-6	1996	Likewise, an inhibition of phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced interleukin 2 (IL-2) protein secretion, which correlated to decreased IL-2 gene transcription, was induced by both cannabinol and Delta9-THC.	Tetradecanoylphorbol Acetate	60-63	interleukin 2	Mus musculus	83-96
8662742-6	1996	Likewise, an inhibition of phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced interleukin 2 (IL-2) protein secretion, which correlated to decreased IL-2 gene transcription, was induced by both cannabinol and Delta9-THC.	Tetradecanoylphorbol Acetate	60-63	interleukin 2	Mus musculus	98-102
8662742-6	1996	Likewise, an inhibition of phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced interleukin 2 (IL-2) protein secretion, which correlated to decreased IL-2 gene transcription, was induced by both cannabinol and Delta9-THC.	Tetradecanoylphorbol Acetate	60-63	interleukin 2	Mus musculus	153-157
18070609-2	2008	Here, it is shown that the proinflammatory mediator lipopolysaccharide (LPS) inhibits the induction of Prx I expression and promoter activity by the phorbol ester 12-O-tetradecanoylphorbol- 13-acetate (TPA) in RAW264.7 monocytes, but not that of cyclooxygenase-2.	Tetradecanoylphorbol Acetate	202-205	peroxiredoxin 1	Homo sapiens	103-108
8662742-7	1996	Further, cannabinoid treatment also decreased PMA/ionomycin-induced nuclear factor binding to the AP-1 proximal site of the IL-2 promoter.	Tetradecanoylphorbol Acetate	46-49	interleukin 2	Mus musculus	124-128
18070609-3	2008	LPS-dependent repression of Prx I induction by TPA was mediated via a newly identified kappaB site in the Prx I promoter, but the "classical" NF-kappaB cascade was not involved in this regulatory pathway, because IkappaB did not affect LPS-mediated Prx I repression.	Tetradecanoylphorbol Acetate	47-50	peroxiredoxin 1	Homo sapiens	28-33
8652659-1	1996	The upstream region of the human NAD(P)H:quinone oxidoreductase (NQO1) gene contains a functional antioxidant responsive element (ARE) and an overlapping 12-O-tetradecanoyl-phorbol-13-acetate responsive element (TRE), with the sequence TGACTCAGCA.	Tetradecanoylphorbol Acetate	154-191	crystallin zeta	Homo sapiens	41-63
18070609-3	2008	LPS-dependent repression of Prx I induction by TPA was mediated via a newly identified kappaB site in the Prx I promoter, but the "classical" NF-kappaB cascade was not involved in this regulatory pathway, because IkappaB did not affect LPS-mediated Prx I repression.	Tetradecanoylphorbol Acetate	47-50	peroxiredoxin 1	Homo sapiens	106-111
18070609-3	2008	LPS-dependent repression of Prx I induction by TPA was mediated via a newly identified kappaB site in the Prx I promoter, but the "classical" NF-kappaB cascade was not involved in this regulatory pathway, because IkappaB did not affect LPS-mediated Prx I repression.	Tetradecanoylphorbol Acetate	47-50	peroxiredoxin 1	Homo sapiens	106-111
8639791-1	1996	PU.1, a member of the ets transcription factor family, has been previously shown to be necessary for tetradecanoylphorbol-13 acetate (TPA)-induced U937 leukemic cell maturation.	Tetradecanoylphorbol Acetate	134-137	Spi-1 proto-oncogene	Homo sapiens	0-4
18197699-4	2008	Here we characterize STAT5 tyrosine phosphorylation and its interaction with LMW-PTP during early phorbol-12-myristate-13-acetate-induced megakaryocyte differentiation; these processes show clear dependence on STAT5 threonine phosphorylation.	Tetradecanoylphorbol Acetate	98-129	signal transducer and activator of transcription 5A	Homo sapiens	21-26
8639791-4	1996	However, TPA treatment induced phosphorylation of PU.1.	Tetradecanoylphorbol Acetate	9-12	Spi-1 proto-oncogene	Homo sapiens	50-54
8639791-5	1996	Gel-shift analysis using a labeled PU.1 oligomer showed that TPA induced a unique PU.1 binding activity.	Tetradecanoylphorbol Acetate	61-64	Spi-1 proto-oncogene	Homo sapiens	35-39
8639791-5	1996	Gel-shift analysis using a labeled PU.1 oligomer showed that TPA induced a unique PU.1 binding activity.	Tetradecanoylphorbol Acetate	61-64	Spi-1 proto-oncogene	Homo sapiens	82-86
8639791-7	1996	The PU.1 binding activity was generated at TPA-13 concentrations stimulating growth arrest and was blocked by the PKC inhibitor GF109203X, which antagonized TPA-induced growth inhibition.	Tetradecanoylphorbol Acetate	43-46	Spi-1 proto-oncogene	Homo sapiens	4-8
8639791-7	1996	The PU.1 binding activity was generated at TPA-13 concentrations stimulating growth arrest and was blocked by the PKC inhibitor GF109203X, which antagonized TPA-induced growth inhibition.	Tetradecanoylphorbol Acetate	157-160	Spi-1 proto-oncogene	Homo sapiens	4-8
8639791-11	1996	These data suggest that TPA-induced growth inhibition is associated with phosphorylation of PU.1 and generation of a unique PU.1 binding activity.	Tetradecanoylphorbol Acetate	24-27	Spi-1 proto-oncogene	Homo sapiens	92-96
8639791-11	1996	These data suggest that TPA-induced growth inhibition is associated with phosphorylation of PU.1 and generation of a unique PU.1 binding activity.	Tetradecanoylphorbol Acetate	24-27	Spi-1 proto-oncogene	Homo sapiens	124-128
8807503-3	1996	TNF-alpha, IL-1 beta, phorbol ester (PMA), and calcium ionophore A23187 were found to stimulate GM-CSF production from K-562 cells.	Tetradecanoylphorbol Acetate	37-40	colony stimulating factor 2	Homo sapiens	96-102
8649402-6	1996	PAC-1 transcription induced by phorbol myristate acetate stimulation and the expression of the v-ras or v-raf oncogene is mediated via the E-box motif and an AP-2-related site and coincides with increased binding activity of the constitutive 53-kDa E-box-binding protein and induced binding of AP-2.	Tetradecanoylphorbol Acetate	31-56	dual specificity phosphatase 2	Mus musculus	0-5
8776733-1	1996	The mouse lactoferrin gene responded to forskolin, 12-O-tetradecanoyl phorbol-13-acetate, and epidermal growth factor (EGF) stimulation via two adjacent enhancer elements, the cAMP response element (CRE) and EGF response element (EGFRE), collectively referred to as the mitogen response unit.	Tetradecanoylphorbol Acetate	51-88	lactotransferrin	Mus musculus	10-21
8722631-9	1996	Steady-state concentrations of mRNA encoding PGF2 alpha-R were decreased (p &lt; 0.05) by PGF2 alpha and PMA treatment (4 and 12 h) but were increased (p &lt; 0.05) at 24 h after LH treatment.	Tetradecanoylphorbol Acetate	105-108	prostaglandin F synthase 2	Bos taurus	45-49
18197699-4	2008	Here we characterize STAT5 tyrosine phosphorylation and its interaction with LMW-PTP during early phorbol-12-myristate-13-acetate-induced megakaryocyte differentiation; these processes show clear dependence on STAT5 threonine phosphorylation.	Tetradecanoylphorbol Acetate	98-129	signal transducer and activator of transcription 5A	Homo sapiens	210-215
8707349-4	1996	Activation of protein kinase C by phorbol myristate acetate or triggering of CD28 on T cells by monoclonal antibody 9.3 provided accessory signals for enhanced GM-CSF production in activated T cells.	Tetradecanoylphorbol Acetate	34-59	colony stimulating factor 2	Homo sapiens	160-166
8661368-12	1996	Taken together, VT enhanced andsolidusor delayed peak IL-2, IL-4, and IL-5 gene expression and secretion in CD4(+) T cells stimulated with PMA and ionomycin.	Tetradecanoylphorbol Acetate	139-142	interleukin 5	Mus musculus	70-74
18197699-5	2008	Since protein kinase C inhibition prevents phorbol-12-myristate-13-acetate-induced STAT5 threonine phosphorylation and association with LMW-PTP, it follows that these processes depend on protein kinase C activity.	Tetradecanoylphorbol Acetate	43-74	signal transducer and activator of transcription 5A	Homo sapiens	83-88
18759962-6	2008	RESULTS: Immature KG-1 cells expressing HLA-B27 display an intracellular source of MHC class I heavy-chain homodimers partially overlapping with the Golgi bodies, but not the endoplasmic reticulum, which is lost at cell maturation with phorbyl-12-myristate-13-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	269-272	major histocompatibility complex, class I, B	Homo sapiens	40-47
8679684-3	1996	Treatment of the cells with TPA increased the activities of sPLA2 and cyclooxygenase.	Tetradecanoylphorbol Acetate	28-31	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	70-84
8630334-2	1996	Neurotrophin-3 increased binding activities in nuclear extracts of MC3T3-E1 cells to TPA-responsive element (TRE), cyclic AMP-responsive element (CRE) and serum-responsive element (SRE), but not binding activity in the nuclear extracts to c-Myc binding DNA element.	Tetradecanoylphorbol Acetate	85-88	neurotrophin 3	Mus musculus	0-14
8622882-7	1996	Gel shift assays demonstrated the mobility pattern of TPA-responsive element (TRE) binding complex with AP-1 derived from H-ras transfectants migrated faster than those from Balb-Neo1, v-myc and H-ras/v-myc.	Tetradecanoylphorbol Acetate	54-57	neogenin	Mus musculus	179-183
19346587-4	2008	We found that matrine inhibited both MMP-1 mRNA and protein expression induced by PMA (phorbol myristate acetate).	Tetradecanoylphorbol Acetate	87-112	matrix metallopeptidase 1	Homo sapiens	37-42
8621772-3	1996	Urea inducibility of Egr-1 expression was protein kinase C (PKC)-dependent because staurosporine and calphostin C abrogated the urea effect, and down-regulation of PHC through chronic TPa treatment inhibited both urea-inducible Egr-1 protein expression and gene transcription.	Tetradecanoylphorbol Acetate	184-187	early growth response 1	Mus musculus	21-26
8621772-5	1996	Importantly, urea-inducible Egr-1 expression was strongly genistein-sensitive, to a much greater extent than the comparable TPA-inducible Egr-1 expression.	Tetradecanoylphorbol Acetate	124-127	early growth response 1	Mus musculus	138-143
8657566-4	1996	The results indicated that hXBP-1 binds preferably to the CRE-like element GAT-GACGTG(T/G)NNN(A/T)T, wherein the core sequence ACGT is highly conserved, and that it also binds to some TPA response elements (TRE).	Tetradecanoylphorbol Acetate	184-187	X-box binding protein 1	Homo sapiens	27-33
8722631-10	1996	In summary, 1) mRNA encoding PGF2 alpha-R was localized to large luteal cells; 2) concentrations of mRNA encoding PGF2 alpha-R did not vary during the estrous cycle; 3) treatment with PGF2 alpha or PMA to activate protein kinase C decreased concentrations of PGF2 alpha-R mRNA within 4 h of treatment; and 4) administration LH increased concentrations of mRNA encoding PGF2 alpha-R 24 h following injection.	Tetradecanoylphorbol Acetate	198-201	prostaglandin F synthase 2	Bos taurus	29-33
8707354-6	1996	Preincubation with anti-thrombin compounds such as hirudin and antithrombin-III-heparin almost completely suppressed the action of thrombin without affecting the actions of other stimuli including IL-1 beta, phorbol 12-myristate 13-acetate (PMA) and TRAP.	Tetradecanoylphorbol Acetate	208-239	serpin family C member 1	Homo sapiens	63-79
8707354-6	1996	Preincubation with anti-thrombin compounds such as hirudin and antithrombin-III-heparin almost completely suppressed the action of thrombin without affecting the actions of other stimuli including IL-1 beta, phorbol 12-myristate 13-acetate (PMA) and TRAP.	Tetradecanoylphorbol Acetate	241-244	serpin family C member 1	Homo sapiens	63-79
8613475-2	1996	We have examined the interaction between the plasminogen activator (PA)-plasmin system and matrix metalloproteinases (MMPs) in HT1080 human fibrosarcoma cells treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	172-209	matrix metallopeptidase 1	Homo sapiens	118-122
8739233-2	1996	Under dual whole-cell voltage-clamp, PKC activation by 100 nM TPA increased g(j) by 16 +/- 2% (mean +/- S.E.M, n = 9), 1.5 mM of the PKG activator 8-bromo-cGMP (8Br-cGMP) decreased g(j) by 26 +/- 2% (n = 4), whereas 1.5 mM of the PKA activator 8Br-cAMP did not affect g(j) (1 +/- 5%, n = 11).	Tetradecanoylphorbol Acetate	62-65	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	230-233
8613475-4	1996	TPA treatment of HT1080 cells induced the expression of interstitial collagenase (MMP-1) and increased the expression of gelatinase B (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), and MT-MMP, a membrane-bound activator of progelatinase A (proMMP-2), while MMP-2 and TIMP-2 expression were decreased.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 1	Homo sapiens	56-80
19346587-8	2008	These results suggest that matrine suppresses PMA-induced MMP-1 expression through inhibition of the AP-1 signaling pathway and also may be beneficial for treatment of some inflammatory skin disorders.	Tetradecanoylphorbol Acetate	46-49	matrix metallopeptidase 1	Homo sapiens	58-63
8613475-4	1996	TPA treatment of HT1080 cells induced the expression of interstitial collagenase (MMP-1) and increased the expression of gelatinase B (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), and MT-MMP, a membrane-bound activator of progelatinase A (proMMP-2), while MMP-2 and TIMP-2 expression were decreased.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 1	Homo sapiens	82-87
8797807-0	1996	The significance of Ser1029 of the heat-stable enterotoxin receptor (STaR): relation of STa-mediated guanylyl cyclase activation and signaling by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	146-171	GCY	Homo sapiens	69-72
8797807-2	1996	Preincubation of the wild type-STaR (wt-STaR) transfectant with 1 microM PMA caused additional STa-mediated guanylyl cyclase (GC) activation compared to control, whereas the mS1029A- and C delta 1029-transfected cells did not show a similar enhanced GC activation by PMA.	Tetradecanoylphorbol Acetate	73-76	GCY	Homo sapiens	31-34
18172297-7	2008	In dermal fibroblast primary culture, TPA can induce activation of the PLC epsilon lipase activity, which leads to the induction of IL-1 alpha expression.	Tetradecanoylphorbol Acetate	38-41	interleukin 1 alpha	Mus musculus	132-142
8635230-7	1996	This is blocked by both phorbol 12-myristate 13-acetate (PMA) pretreatment to downregulate PKC and the PKC inhibitor chelerythrine, arguing that PKCepsilon plays a critical role in endothelin receptor-dependent increases in intracellular calcium.	Tetradecanoylphorbol Acetate	24-55	endothelin 1	Mus musculus	181-191
8635230-7	1996	This is blocked by both phorbol 12-myristate 13-acetate (PMA) pretreatment to downregulate PKC and the PKC inhibitor chelerythrine, arguing that PKCepsilon plays a critical role in endothelin receptor-dependent increases in intracellular calcium.	Tetradecanoylphorbol Acetate	57-60	endothelin 1	Mus musculus	181-191
8615820-1	1996	(1) Treatment of resident peritoneal macrophages for 8 h with macrophage colony-stimulating factor (M-CSF) increased release of superoxide anion (O2-) stimulated by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	165-196	colony stimulating factor 1	Homo sapiens	62-98
8615820-1	1996	(1) Treatment of resident peritoneal macrophages for 8 h with macrophage colony-stimulating factor (M-CSF) increased release of superoxide anion (O2-) stimulated by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	165-196	colony stimulating factor 1	Homo sapiens	100-105
17652337-7	2007	During the activation phase, the levels of p50, p65, specificity protein 1 (Sp1) and nucleophosmin (NPM) increase after TPA treatments.	Tetradecanoylphorbol Acetate	120-123	golgi reassembly stacking protein 1	Homo sapiens	48-51
8607862-6	1996	Furthermore the phosphorylation sites of p47-phox by calyculin A treatment were different from those by PMA treatment.	Tetradecanoylphorbol Acetate	104-107	pleckstrin	Homo sapiens	41-44
17976640-4	2007	All agonist treatments resulted in S2248 phosphorylation of mTOR and T389 and S421/T424 phosphorylation of S6K1, however only ET-1 and TPA-stimulated mTOR/S6K1 activation was abolished with infection of a dominant negative adenoviral c-Raf (DN-Raf) construct.	Tetradecanoylphorbol Acetate	135-138	ribosomal protein S6 kinase B1	Homo sapiens	107-111
8636132-6	1996	The hydroxamic acid-based peptide was also found to inhibit wild type L-selectin down-regulation from the surfaces of phorbol myristate acetate-activated peripheral blood lymphocytes and phytohemagglutinin-stimulated lymphoblasts.	Tetradecanoylphorbol Acetate	118-143	selectin L	Homo sapiens	70-80
17976640-4	2007	All agonist treatments resulted in S2248 phosphorylation of mTOR and T389 and S421/T424 phosphorylation of S6K1, however only ET-1 and TPA-stimulated mTOR/S6K1 activation was abolished with infection of a dominant negative adenoviral c-Raf (DN-Raf) construct.	Tetradecanoylphorbol Acetate	135-138	ribosomal protein S6 kinase B1	Homo sapiens	155-159
8619614-7	1996	The induction of the CYP2H1 gene by phenobarbital was not altered by treating cells with the specific inhibitors for protein kinase C (GF 109203X and Ro 31-8220) or prolonged exposure to 12-O-tetradecanoyl-phorbol 13-acetate (TPA) or treatment with the specific inhibitors for tyrosine kinase (genistein and tyrphostin A25).	Tetradecanoylphorbol Acetate	226-229	cytochrome P450 2H1	Gallus gallus	21-27
8605587-5	1996	Addition of r-hTBP-1 to U1 cells during the last 4 h of a 24 h incubation with PMA still inhibited p24 antigen production by 15%.	Tetradecanoylphorbol Acetate	79-82	TNF receptor superfamily member 1A	Homo sapiens	14-20
8605587-6	1996	U1 cells stimulated with 10(-7) M PMA released approximately 1 ng/ml endogenous TBP-1 with an initial peak observed at 1 h and a second peak at 24 h after PMA stimulation.	Tetradecanoylphorbol Acetate	34-37	TNF receptor superfamily member 1A	Homo sapiens	80-85
18171992-9	2007	Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	92-95	epidermal growth factor receptor	Mus musculus	18-50
8605587-6	1996	U1 cells stimulated with 10(-7) M PMA released approximately 1 ng/ml endogenous TBP-1 with an initial peak observed at 1 h and a second peak at 24 h after PMA stimulation.	Tetradecanoylphorbol Acetate	155-158	TNF receptor superfamily member 1A	Homo sapiens	80-85
18171992-9	2007	Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	92-95	epidermal growth factor receptor	Mus musculus	52-56
18171992-9	2007	Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	92-95	epidermal growth factor receptor	Mus musculus	146-150
8631129-4	1996	In the latter cell line, PAI-2 induction by TCDD and by 12-O-tetradecanoyl phorbol-13-acetate (TPA) has been compared.	Tetradecanoylphorbol Acetate	56-93	serpin family B member 2	Homo sapiens	25-30
18171992-9	2007	Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	92-95	epidermal growth factor receptor	Mus musculus	146-150
8631129-5	1996	TCDD appeared to be less efficient than TPA as an inducer of PAI-2.	Tetradecanoylphorbol Acetate	40-43	serpin family B member 2	Homo sapiens	61-66
8786306-6	1996	PMA strongly induced the expression of LT-beta mRNA, and the level of induction was not changed markedly by cycloheximide (CHX) treatment.	Tetradecanoylphorbol Acetate	0-3	lymphotoxin beta	Homo sapiens	39-46
18171992-9	2007	Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	92-95	erb-b2 receptor tyrosine kinase 2	Mus musculus	207-212
8608807-1	1996	Tumor necrosis factor (TNF), like granulocyte-macrophage colony-stimul ating factor (GM-CSF), rapidly primed human monocytes for enhanced release of superoxide (O-2) stimulated by receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A), but not by phorbol myristate acetate (PMA), which bypasses the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	294-319	colony stimulating factor 2	Homo sapiens	34-83
8617995-1	1996	The cellular distribution of mRNAS for urokinase-type plasminogen activator (uPA), its specific receptor (uPAR), and its inhibitors (PAI-1 and -2) in mouse skin was analyzed by in situ hybridization after topical application of the tumor promoter phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	247-278	plasminogen activator, urokinase	Mus musculus	39-75
8608807-1	1996	Tumor necrosis factor (TNF), like granulocyte-macrophage colony-stimul ating factor (GM-CSF), rapidly primed human monocytes for enhanced release of superoxide (O-2) stimulated by receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A), but not by phorbol myristate acetate (PMA), which bypasses the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	294-319	colony stimulating factor 2	Homo sapiens	85-91
18171992-9	2007	Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	92-95	epidermal growth factor receptor	Mus musculus	146-150
8608807-1	1996	Tumor necrosis factor (TNF), like granulocyte-macrophage colony-stimul ating factor (GM-CSF), rapidly primed human monocytes for enhanced release of superoxide (O-2) stimulated by receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A), but not by phorbol myristate acetate (PMA), which bypasses the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	321-324	colony stimulating factor 2	Homo sapiens	34-83
8608807-1	1996	Tumor necrosis factor (TNF), like granulocyte-macrophage colony-stimul ating factor (GM-CSF), rapidly primed human monocytes for enhanced release of superoxide (O-2) stimulated by receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A), but not by phorbol myristate acetate (PMA), which bypasses the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	321-324	colony stimulating factor 2	Homo sapiens	85-91
8617995-5	1996	In the dermis, 5 h after application of phorbol 12-myristate 13-acetate to the skin, uPA mRNA was detected in fibroblast-like cells below and around the skin muscle, and PAI-1 mRNA was detected in stromal cells located above the skin muscle.	Tetradecanoylphorbol Acetate	40-71	plasminogen activator, urokinase	Mus musculus	85-88
8617995-5	1996	In the dermis, 5 h after application of phorbol 12-myristate 13-acetate to the skin, uPA mRNA was detected in fibroblast-like cells below and around the skin muscle, and PAI-1 mRNA was detected in stromal cells located above the skin muscle.	Tetradecanoylphorbol Acetate	40-71	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	170-175
8617995-6	1996	After longer exposure to phorbol 12-myristate 13-acetate, the PAI-1 mRNA-expressing stromal cells were located more superficially, apparently moving toward the epidermal layer.	Tetradecanoylphorbol Acetate	25-56	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	62-67
8617995-8	1996	Up to 24 h after the application of phorbol 12-myristate 13-acetate, the intensity of the signal for both uPA and PAI-1 increased, followed by a gradual decrease for up to 7 days.	Tetradecanoylphorbol Acetate	36-67	plasminogen activator, urokinase	Mus musculus	106-109
18171992-9	2007	Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	92-95	erb-b2 receptor tyrosine kinase 2	Mus musculus	313-318
8636443-4	1996	Epinephrine- and PMA-promoted AA release and activation of the PLA2 were inhibited by AACOCF3, an inhibitor of the 85-kD cPLA2.	Tetradecanoylphorbol Acetate	17-20	phospholipase A2 group IB	Canis lupus familiaris	63-67
18171992-9	2007	Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	246-249	epidermal growth factor receptor	Mus musculus	18-50
18171992-9	2007	Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	246-249	epidermal growth factor receptor	Mus musculus	52-56
8648910-6	1996	Short term incubation (5 min) with the active phorbol ester, phorbol 12-myristate, 13-acetate (PMA), 10(-7) M, caused a significant stimulation of the Na-HCO3 cotransporter activity as compared to controls.	Tetradecanoylphorbol Acetate	95-98	electrogenic sodium bicarbonate cotransporter 1	Oryctolagus cuniculus	151-172
8617995-8	1996	Up to 24 h after the application of phorbol 12-myristate 13-acetate, the intensity of the signal for both uPA and PAI-1 increased, followed by a gradual decrease for up to 7 days.	Tetradecanoylphorbol Acetate	36-67	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	114-119
18171992-9	2007	Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	246-249	epidermal growth factor receptor	Mus musculus	18-50
8617999-5	1996	Treatment of mouse skin with 12-0-tetradecanoyl-phorbol-13-acetate (TPA) produced a large increase in cornifin-alpha/SPRR1 protein and mRNA.	Tetradecanoylphorbol Acetate	68-71	small proline rich protein 1B	Homo sapiens	117-122
8617999-6	1996	Immunohistochemical localization of cornifin-alpha/SPRR1 in TPA-treated skin indicated that cornifin-alpha/SPRR1 was increased in the suprabasal epidermis but not in the follicle.	Tetradecanoylphorbol Acetate	60-63	small proline rich protein 1B	Homo sapiens	51-56
18171992-9	2007	Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	246-249	epidermal growth factor receptor	Mus musculus	52-56
8617999-6	1996	Immunohistochemical localization of cornifin-alpha/SPRR1 in TPA-treated skin indicated that cornifin-alpha/SPRR1 was increased in the suprabasal epidermis but not in the follicle.	Tetradecanoylphorbol Acetate	60-63	small proline rich protein 1B	Homo sapiens	107-112
8618003-4	1996	On Northern blot analysis, the baseline expression of the 1.2-kb POMC transcript was upregulated by ultraviolet radiation (UVR) or by stimulation with interleukin-1 alpha (IL-1 alpha) or phorbol 12-tetradecanoate 13-acetate (TPA).	Tetradecanoylphorbol Acetate	225-228	interleukin 1 alpha	Homo sapiens	151-170
8621230-7	1996	This effect is very likely not due to inhibition of translocation of PKC to the membrane as Ro 31-8220 enhances, rather than inhibits, PMA-induced transfer of PKC beta(II) to the particulate fraction.	Tetradecanoylphorbol Acetate	135-138	phospholipase C, beta 2	Rattus norvegicus	159-171
17617058-8	2007	In cells, the IGF-1-stimulated phosphorylations, and certain EGF-stimulated phosphorylations, were inhibited by PI3K (phosphoinositide 3-kinase) inhibitors, whereas the RSK inhibitor BI-D1870 inhibited the PMA-induced phosphorylations.	Tetradecanoylphorbol Acetate	206-209	epidermal growth factor	Homo sapiens	61-64
8779927-4	1996	Under the same growth-inhibitory conditions of PMA addition, aggregation of phosphatidylinositol 3-kinase (PI3K) to the fibroblast growth factor receptor and tyrosine phosphorylation of the 85-kDa regulatory component of the signal transfer protein PI3K are reduced by 94 and 79%, respectively.	Tetradecanoylphorbol Acetate	47-50	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	76-105
8654390-2	1996	The human heme-oxygenase-1 gene is transcriptionally activated through the cis-regulatory element (MTE), GTCATATGAC (positions -156 to -147), during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of myelomonocytic cell lines, such as THP-1, to macrophages.	Tetradecanoylphorbol Acetate	149-185	heme oxygenase 1	Homo sapiens	10-26
8631823-5	1996	p130cas phosphorylation was rapidly reversible upon disengagement of the LFA-1-ICAM-1 complex and required cell adhesion since binding of phorbol 12-myristate 13-acetate-stimulated JY cells to purified ICAM-1 or cross-linking of either LFA-1 or ICAM-1 was not sufficient to induce phosphorylation of p130cas.	Tetradecanoylphorbol Acetate	138-169	BCAR1 scaffold protein, Cas family member	Homo sapiens	0-7
9095468-4	1996	Fru-2,6-P2 content as well as PFK-2 activity were increased in a dose-dependent manner after 4 days of incubation with PMA.	Tetradecanoylphorbol Acetate	119-122	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	30-35
8654390-2	1996	The human heme-oxygenase-1 gene is transcriptionally activated through the cis-regulatory element (MTE), GTCATATGAC (positions -156 to -147), during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of myelomonocytic cell lines, such as THP-1, to macrophages.	Tetradecanoylphorbol Acetate	149-185	metallothionein 1I, pseudogene	Homo sapiens	99-102
17407154-0	2007	The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells.	Tetradecanoylphorbol Acetate	127-130	prostaglandin F2 receptor inhibitor	Homo sapiens	74-80
8654390-2	1996	The human heme-oxygenase-1 gene is transcriptionally activated through the cis-regulatory element (MTE), GTCATATGAC (positions -156 to -147), during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of myelomonocytic cell lines, such as THP-1, to macrophages.	Tetradecanoylphorbol Acetate	187-190	heme oxygenase 1	Homo sapiens	10-26
8654390-2	1996	The human heme-oxygenase-1 gene is transcriptionally activated through the cis-regulatory element (MTE), GTCATATGAC (positions -156 to -147), during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of myelomonocytic cell lines, such as THP-1, to macrophages.	Tetradecanoylphorbol Acetate	187-190	metallothionein 1I, pseudogene	Homo sapiens	99-102
8599973-7	1996	At optimal concentrations, lipopolysaccharide (LPS), IL-1beta, interferon-gamma (IFN-gamma), and tumor-promoting phorbol diester (TPA) could all stimulate HA22T/VGH cells to secrete GM-CSF.	Tetradecanoylphorbol Acetate	130-133	colony stimulating factor 2	Homo sapiens	182-188
17407154-4	2007	TPA increased targeting of CD81 and CD9P-1 into exosomes but strongly reduced the localization of the TfR in these vesicles.	Tetradecanoylphorbol Acetate	0-3	prostaglandin F2 receptor inhibitor	Homo sapiens	36-42
17716656-7	2007	Concanavalin-A, an inhibitor of receptor internalization decreased both constitutive and PMA-induced Frizzled-7 cleavage, while inhibition of the endocytic pathway with Delta95-295-Eps15 dominant-negative prevented only PMA-induced Frizzled-7 cleavage.	Tetradecanoylphorbol Acetate	89-92	frizzled class receptor 7	Homo sapiens	101-111
8690890-11	1996	A small subpopulation of CD4+ T cell from the 2C-transgenic mouse expressed the transgenic TCR alpha:beta heterodimer as detected by the 1B2 anti-2C clonotypic mAb; both 1B2+ and 1B2- subpopulations proliferated poorly in response to anti-CD3 and to PMA + ionomycin.	Tetradecanoylphorbol Acetate	250-253	T cell receptor alpha variable 6-3	Mus musculus	91-94
17716656-7	2007	Concanavalin-A, an inhibitor of receptor internalization decreased both constitutive and PMA-induced Frizzled-7 cleavage, while inhibition of the endocytic pathway with Delta95-295-Eps15 dominant-negative prevented only PMA-induced Frizzled-7 cleavage.	Tetradecanoylphorbol Acetate	89-92	frizzled class receptor 7	Homo sapiens	232-242
17894822-1	2007	Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) was investigated in Calu-6 and Cos-7 cells under the influence of 4beta-phorbol 12-myristate 13-acetate (PMA), forskolin, dioxin and the heavy metals copper, nickel and cobalt.	Tetradecanoylphorbol Acetate	159-196	tumor protein, translationally-controlled 1	Homo sapiens	24-28
21544391-2	1996	TPA suppressed the growth of OCI/AML-1 and OCI/AML-5 cells but stimulated the proliferation of OCI/AML-4 cells.	Tetradecanoylphorbol Acetate	0-3	RUNX family transcription factor 1	Homo sapiens	33-38
17894822-1	2007	Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) was investigated in Calu-6 and Cos-7 cells under the influence of 4beta-phorbol 12-myristate 13-acetate (PMA), forskolin, dioxin and the heavy metals copper, nickel and cobalt.	Tetradecanoylphorbol Acetate	159-196	tumor protein, translationally-controlled 1	Homo sapiens	45-85
9157684-7	1996	These inhibitors also significantly reduced both phorbol myristate acetate (PMA)-induced primary and secondary granule (lactoferrin) release.	Tetradecanoylphorbol Acetate	49-74	lactotransferrin	Bos taurus	120-131
9157684-7	1996	These inhibitors also significantly reduced both phorbol myristate acetate (PMA)-induced primary and secondary granule (lactoferrin) release.	Tetradecanoylphorbol Acetate	76-79	lactotransferrin	Bos taurus	120-131
17894822-1	2007	Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) was investigated in Calu-6 and Cos-7 cells under the influence of 4beta-phorbol 12-myristate 13-acetate (PMA), forskolin, dioxin and the heavy metals copper, nickel and cobalt.	Tetradecanoylphorbol Acetate	198-201	tumor protein, translationally-controlled 1	Homo sapiens	24-28
8635491-2	1996	Chronic treatment with low doses (0.1-0.5 nM) of phorbol 12-myristate 13-acetate (PMA) had no mitogenic action when given alone, but significantly enhanced epidermal growth factor (EGF)-induced growth.	Tetradecanoylphorbol Acetate	49-80	epidermal growth factor	Mus musculus	156-179
17894822-1	2007	Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) was investigated in Calu-6 and Cos-7 cells under the influence of 4beta-phorbol 12-myristate 13-acetate (PMA), forskolin, dioxin and the heavy metals copper, nickel and cobalt.	Tetradecanoylphorbol Acetate	198-201	tumor protein, translationally-controlled 1	Homo sapiens	45-85
8635491-2	1996	Chronic treatment with low doses (0.1-0.5 nM) of phorbol 12-myristate 13-acetate (PMA) had no mitogenic action when given alone, but significantly enhanced epidermal growth factor (EGF)-induced growth.	Tetradecanoylphorbol Acetate	49-80	epidermal growth factor	Mus musculus	181-184
17407158-9	2007	However, phorbol 12-myristate 13-acetate (PMA), a selective PKC activator induced MGP mRNA expression through activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	9-40	matrix Gla protein	Mus musculus	82-85
8635491-2	1996	Chronic treatment with low doses (0.1-0.5 nM) of phorbol 12-myristate 13-acetate (PMA) had no mitogenic action when given alone, but significantly enhanced epidermal growth factor (EGF)-induced growth.	Tetradecanoylphorbol Acetate	82-85	epidermal growth factor	Mus musculus	156-179
8635491-2	1996	Chronic treatment with low doses (0.1-0.5 nM) of phorbol 12-myristate 13-acetate (PMA) had no mitogenic action when given alone, but significantly enhanced epidermal growth factor (EGF)-induced growth.	Tetradecanoylphorbol Acetate	82-85	epidermal growth factor	Mus musculus	181-184
8635491-6	1996	Acute treatment with 10 ng/ml EGF or 20 nM PMA stimulated phospholipid-dependent PKC translocation from the cytosolic to the membrane fraction, and this effect was blocked by prior treatment for 7 days with 20 nM PMA.	Tetradecanoylphorbol Acetate	213-216	epidermal growth factor	Mus musculus	30-33
8635491-8	1996	Additional studies showed that treatment with 1-2 nM PMA caused an increase, whereas treatment with 5-100 nM PMA caused a dose-related decrease in EGF-dependent EGF-receptor (EGF-R) autophosphorylation, In summary, these findings suggest that submitogenic doses of PMA potentiate EGF-induced cell growth by enhancing EGF-R mitogenic signaling, whereas the mitogenic effects of high doses of PMA alone appear to be mediated through PKC- and EGF-independent mechanisms.	Tetradecanoylphorbol Acetate	53-56	epidermal growth factor	Mus musculus	147-150
17407158-9	2007	However, phorbol 12-myristate 13-acetate (PMA), a selective PKC activator induced MGP mRNA expression through activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	42-45	matrix Gla protein	Mus musculus	82-85
8635491-8	1996	Additional studies showed that treatment with 1-2 nM PMA caused an increase, whereas treatment with 5-100 nM PMA caused a dose-related decrease in EGF-dependent EGF-receptor (EGF-R) autophosphorylation, In summary, these findings suggest that submitogenic doses of PMA potentiate EGF-induced cell growth by enhancing EGF-R mitogenic signaling, whereas the mitogenic effects of high doses of PMA alone appear to be mediated through PKC- and EGF-independent mechanisms.	Tetradecanoylphorbol Acetate	53-56	epidermal growth factor	Mus musculus	161-164
8635491-8	1996	Additional studies showed that treatment with 1-2 nM PMA caused an increase, whereas treatment with 5-100 nM PMA caused a dose-related decrease in EGF-dependent EGF-receptor (EGF-R) autophosphorylation, In summary, these findings suggest that submitogenic doses of PMA potentiate EGF-induced cell growth by enhancing EGF-R mitogenic signaling, whereas the mitogenic effects of high doses of PMA alone appear to be mediated through PKC- and EGF-independent mechanisms.	Tetradecanoylphorbol Acetate	53-56	epidermal growth factor	Mus musculus	431-443
17803520-7	2007	Moreover, incubation with melatonin induces a decrease in p21 expression in these cells that is partially blocked by co-incubation with TPA.	Tetradecanoylphorbol Acetate	136-139	H3 histone pseudogene 16	Homo sapiens	58-61
8631300-1	1996	Overexpression of a TPA-insensitive PKC member, an atypical protein kinase C (aPKClambda), results in an enhancement of the transcriptional activation of TPA response element (TRE) in cells stimulated with epidermal growth factor (EGF) or platelet-derived growth factor (PDGF).	Tetradecanoylphorbol Acetate	20-23	epidermal growth factor	Homo sapiens	206-229
8631300-1	1996	Overexpression of a TPA-insensitive PKC member, an atypical protein kinase C (aPKClambda), results in an enhancement of the transcriptional activation of TPA response element (TRE) in cells stimulated with epidermal growth factor (EGF) or platelet-derived growth factor (PDGF).	Tetradecanoylphorbol Acetate	20-23	epidermal growth factor	Homo sapiens	231-234
17595323-10	2007	Treatment of cumulus oocyte complexes or granulosa cells with FSH/amphiregulin, LH, or forskolin/phorbol 12-myristate 13-acetate-induced elevated expression of Snap25 mRNA and increased the secretion of eight cytokine and chemokine factors.	Tetradecanoylphorbol Acetate	97-128	synaptosomal-associated protein 25	Mus musculus	160-166
8631300-1	1996	Overexpression of a TPA-insensitive PKC member, an atypical protein kinase C (aPKClambda), results in an enhancement of the transcriptional activation of TPA response element (TRE) in cells stimulated with epidermal growth factor (EGF) or platelet-derived growth factor (PDGF).	Tetradecanoylphorbol Acetate	154-157	epidermal growth factor	Homo sapiens	206-229
8631300-1	1996	Overexpression of a TPA-insensitive PKC member, an atypical protein kinase C (aPKClambda), results in an enhancement of the transcriptional activation of TPA response element (TRE) in cells stimulated with epidermal growth factor (EGF) or platelet-derived growth factor (PDGF).	Tetradecanoylphorbol Acetate	154-157	epidermal growth factor	Homo sapiens	231-234
17678893-5	2007	Analyses using PKC inhibitors and siRNA suggest that PKCepsilon, an isoform typically expressed in ovarian cancer cells, may be important in the TPA-mediated claudin-4 phosphorylation and weakening of the TJs.	Tetradecanoylphorbol Acetate	145-148	protein kinase C epsilon	Homo sapiens	15-18
8576248-1	1996	Tissue factor (TF) gene expression is rapidly induced in epithelial cells by phorbol 12-myristate 13-acetate and serum.	Tetradecanoylphorbol Acetate	77-108	coagulation factor III, tissue factor	Homo sapiens	0-13
8576248-1	1996	Tissue factor (TF) gene expression is rapidly induced in epithelial cells by phorbol 12-myristate 13-acetate and serum.	Tetradecanoylphorbol Acetate	77-108	coagulation factor III, tissue factor	Homo sapiens	15-17
8576248-7	1996	The Sp1 sites mediated basal promoter activity, and both Sp1 and EGR-1 sites were required for maximal induction of the TF promoter by phorbol 12-myristate 13-acetate or serum.	Tetradecanoylphorbol Acetate	135-166	early growth response 1	Homo sapiens	65-70
8576248-7	1996	The Sp1 sites mediated basal promoter activity, and both Sp1 and EGR-1 sites were required for maximal induction of the TF promoter by phorbol 12-myristate 13-acetate or serum.	Tetradecanoylphorbol Acetate	135-166	coagulation factor III, tissue factor	Homo sapiens	120-122
17678893-5	2007	Analyses using PKC inhibitors and siRNA suggest that PKCepsilon, an isoform typically expressed in ovarian cancer cells, may be important in the TPA-mediated claudin-4 phosphorylation and weakening of the TJs.	Tetradecanoylphorbol Acetate	145-148	protein kinase C epsilon	Homo sapiens	53-63
17970088-4	2007	Triptolide inhibited the phorbol 12-myristate 13-acetate (PMA)-induced uPAR mRNA and protein expression in a dose-dependent manner, and reduced the uPAR transcriptional activity.	Tetradecanoylphorbol Acetate	25-56	plasminogen activator, urokinase receptor	Homo sapiens	71-75
8543805-6	1996	In contrast, PMA, which directly activates PKC, induced rapid pim-1 expression.	Tetradecanoylphorbol Acetate	13-16	protein kinase C epsilon	Homo sapiens	43-46
8543805-7	1996	Further, anti-CD3- or PMA-induced pim-1 expression was markedly reduced by various PKC inhibitors and by deficiency of the PKC epsilon isoform in a mutant T cell line.	Tetradecanoylphorbol Acetate	22-25	protein kinase C epsilon	Homo sapiens	83-86
17970088-4	2007	Triptolide inhibited the phorbol 12-myristate 13-acetate (PMA)-induced uPAR mRNA and protein expression in a dose-dependent manner, and reduced the uPAR transcriptional activity.	Tetradecanoylphorbol Acetate	58-61	plasminogen activator, urokinase receptor	Homo sapiens	71-75
8548771-8	1996	Furthermore, all the survival stimuli tested (interleukin 4, anti-IgM antibodies, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate) prevented the decline in Mcl-1 levels.	Tetradecanoylphorbol Acetate	104-140	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	167-172
17970088-6	2007	The signals involved in uPAR induction by PMA were investigated to determine the mechanisms for the triptolide-mediated regulation of uPAR.	Tetradecanoylphorbol Acetate	42-45	plasminogen activator, urokinase receptor	Homo sapiens	24-28
17970088-6	2007	The signals involved in uPAR induction by PMA were investigated to determine the mechanisms for the triptolide-mediated regulation of uPAR.	Tetradecanoylphorbol Acetate	42-45	plasminogen activator, urokinase receptor	Homo sapiens	134-138
17640620-0	2007	Phorbol 12-myristate 13-acetate (PMA)-induced migration of glioblastoma cells is mediated via p38MAPK/Hsp27 pathway.	Tetradecanoylphorbol Acetate	0-31	heat shock protein family B (small) member 1	Homo sapiens	102-107
9084655-0	1996	Adhesion of human myelomonocytic (HL-60) cells induced by 1,25-dihydroxyvitamin D3 and phorbol myristate acetate is dependent on osteopontin synthesis and the alpha v beta 3 integrin.	Tetradecanoylphorbol Acetate	87-112	secreted phosphoprotein 1	Homo sapiens	129-140
9084655-0	1996	Adhesion of human myelomonocytic (HL-60) cells induced by 1,25-dihydroxyvitamin D3 and phorbol myristate acetate is dependent on osteopontin synthesis and the alpha v beta 3 integrin.	Tetradecanoylphorbol Acetate	87-112	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	159-173
9084655-8	1996	The absolute requirement of de novo osteopontin synthesis for the TPA and 1,25-vit D3-induced HL-60 cell adhesion was demonstrated by neutralisation of adhesion using an anti-osteopontin polyclonal antibody as well as following transfection of an antisense osteopontin phosphorothioate-modified oligonucleotide.	Tetradecanoylphorbol Acetate	66-69	secreted phosphoprotein 1	Homo sapiens	36-47
9084655-8	1996	The absolute requirement of de novo osteopontin synthesis for the TPA and 1,25-vit D3-induced HL-60 cell adhesion was demonstrated by neutralisation of adhesion using an anti-osteopontin polyclonal antibody as well as following transfection of an antisense osteopontin phosphorothioate-modified oligonucleotide.	Tetradecanoylphorbol Acetate	66-69	secreted phosphoprotein 1	Homo sapiens	175-186
17640620-0	2007	Phorbol 12-myristate 13-acetate (PMA)-induced migration of glioblastoma cells is mediated via p38MAPK/Hsp27 pathway.	Tetradecanoylphorbol Acetate	33-36	heat shock protein family B (small) member 1	Homo sapiens	102-107
9084655-8	1996	The absolute requirement of de novo osteopontin synthesis for the TPA and 1,25-vit D3-induced HL-60 cell adhesion was demonstrated by neutralisation of adhesion using an anti-osteopontin polyclonal antibody as well as following transfection of an antisense osteopontin phosphorothioate-modified oligonucleotide.	Tetradecanoylphorbol Acetate	66-69	secreted phosphoprotein 1	Homo sapiens	175-186
17928641-9	2007	After the addition of EGF to acini incubated previously with phorbol ester TPA, strong decrease in pY-ERK level was also observed.	Tetradecanoylphorbol Acetate	75-78	epidermal growth factor	Homo sapiens	22-25
8536629-7	1996	Pretreatment with TPA, however, decreased both GnRH- and TPA-induced MAPK activation, suggesting that PKC is involved in GnRH-mediated activation of MAPK.	Tetradecanoylphorbol Acetate	18-21	gonadotropin releasing hormone 1	Mus musculus	47-51
8536629-7	1996	Pretreatment with TPA, however, decreased both GnRH- and TPA-induced MAPK activation, suggesting that PKC is involved in GnRH-mediated activation of MAPK.	Tetradecanoylphorbol Acetate	18-21	gonadotropin releasing hormone 1	Mus musculus	121-125
8536629-7	1996	Pretreatment with TPA, however, decreased both GnRH- and TPA-induced MAPK activation, suggesting that PKC is involved in GnRH-mediated activation of MAPK.	Tetradecanoylphorbol Acetate	57-60	gonadotropin releasing hormone 1	Mus musculus	121-125
8682156-6	1996	PAF production was also increased up to 10- to 13-fold, in a dose- and time-dependent manner, by the addition of calcium and two- to threefold by the addition of phorbol myristate acetate (PMA; 10(-7) to 10(-5) mol L(-1)).	Tetradecanoylphorbol Acetate	162-187	PCNA clamp associated factor	Homo sapiens	0-3
8682156-6	1996	PAF production was also increased up to 10- to 13-fold, in a dose- and time-dependent manner, by the addition of calcium and two- to threefold by the addition of phorbol myristate acetate (PMA; 10(-7) to 10(-5) mol L(-1)).	Tetradecanoylphorbol Acetate	189-192	PCNA clamp associated factor	Homo sapiens	0-3
17562706-7	2007	Using monoclonal anti-CLEC12B antibodies we found de novo expression of this receptor on in vitro generated human macrophages and on the human myelo-monocytic cell line U937 upon phorbol 12-myristate 13-acetate treatment, suggesting that this receptor plays a role in myeloid cell function.	Tetradecanoylphorbol Acetate	179-210	C-type lectin domain family 12 member B	Homo sapiens	22-29
17659432-9	2007	Increase in C/EBPbeta mRNA stability in HD11 cells was induced by forskolin and PMA.	Tetradecanoylphorbol Acetate	80-83	CCAAT/enhancer binding protein beta	Gallus gallus	12-21
8592100-3	1996	It has been proposed that protein kinase C regulates tissue factor expression primarily because phorbol myristate acetate, the protein kinase C activator, induces tissue factor expression.	Tetradecanoylphorbol Acetate	96-121	coagulation factor III, tissue factor	Homo sapiens	53-66
8592100-3	1996	It has been proposed that protein kinase C regulates tissue factor expression primarily because phorbol myristate acetate, the protein kinase C activator, induces tissue factor expression.	Tetradecanoylphorbol Acetate	96-121	coagulation factor III, tissue factor	Homo sapiens	163-176
8592100-7	1996	Calphostin C also inhibited phorbol myristate acetate-induced tissue factor expression.	Tetradecanoylphorbol Acetate	28-53	coagulation factor III, tissue factor	Homo sapiens	62-75
17321722-5	2007	Furthermore, the PKC agonist TPA promotes expression of TSG101 and keratin 10 in keratinocytes under low calcium conditions, while co-treatment with the PKC inhibitor GF 109203X blocks TPA-induced TSG101 and keratin 10 upregulation.	Tetradecanoylphorbol Acetate	29-32	tumor susceptibility 101	Homo sapiens	56-62
8990044-7	1996	Phorbol 12-myristate 13-acetate (TPA) further stimulated c-fos and c-myc expression, whereas treatment with 1,25-vitamin D3 (10(-7) M) it had no effect either in unstimulated or in TPA-stimulated cells.	Tetradecanoylphorbol Acetate	0-31	FBJ osteosarcoma oncogene	Mus musculus	57-62
8990044-7	1996	Phorbol 12-myristate 13-acetate (TPA) further stimulated c-fos and c-myc expression, whereas treatment with 1,25-vitamin D3 (10(-7) M) it had no effect either in unstimulated or in TPA-stimulated cells.	Tetradecanoylphorbol Acetate	33-36	FBJ osteosarcoma oncogene	Mus musculus	57-62
8569182-5	1996	Tyrosine phosphorylation of paxillin was detectable within 15 min after TPA treatment, when only lamellipodia had extended from the colony, and in cells treated with blocking antibodies against integrins beta 1 and beta 5, which strongly inhibited spreading and disorganization while preserving adherens junctions.	Tetradecanoylphorbol Acetate	72-75	paxillin	Homo sapiens	28-36
17321722-5	2007	Furthermore, the PKC agonist TPA promotes expression of TSG101 and keratin 10 in keratinocytes under low calcium conditions, while co-treatment with the PKC inhibitor GF 109203X blocks TPA-induced TSG101 and keratin 10 upregulation.	Tetradecanoylphorbol Acetate	29-32	keratin 10	Homo sapiens	67-77
8992816-6	1996	Invasion is an active process and correlations are observed between cellular invasivness and proteinase production, like uPA, tPA and its inhibitors, for example PAI-1.	Tetradecanoylphorbol Acetate	126-129	serpin family E member 1	Homo sapiens	162-167
17321722-5	2007	Furthermore, the PKC agonist TPA promotes expression of TSG101 and keratin 10 in keratinocytes under low calcium conditions, while co-treatment with the PKC inhibitor GF 109203X blocks TPA-induced TSG101 and keratin 10 upregulation.	Tetradecanoylphorbol Acetate	29-32	tumor susceptibility 101	Homo sapiens	197-203
17321722-5	2007	Furthermore, the PKC agonist TPA promotes expression of TSG101 and keratin 10 in keratinocytes under low calcium conditions, while co-treatment with the PKC inhibitor GF 109203X blocks TPA-induced TSG101 and keratin 10 upregulation.	Tetradecanoylphorbol Acetate	29-32	keratin 10	Homo sapiens	208-218
17321722-5	2007	Furthermore, the PKC agonist TPA promotes expression of TSG101 and keratin 10 in keratinocytes under low calcium conditions, while co-treatment with the PKC inhibitor GF 109203X blocks TPA-induced TSG101 and keratin 10 upregulation.	Tetradecanoylphorbol Acetate	185-188	tumor susceptibility 101	Homo sapiens	197-203
8543769-1	1995	Cyclic adenosine monophosphate (cAMP) inhibits phorbol 12-myristate 13-acetate (PMA)-induced IL-2 production while it inhibits IL-5 production at the transcriptional level in EL-4, a mouse lymphoma line.	Tetradecanoylphorbol Acetate	47-78	interleukin 2	Mus musculus	93-97
8543769-1	1995	Cyclic adenosine monophosphate (cAMP) inhibits phorbol 12-myristate 13-acetate (PMA)-induced IL-2 production while it inhibits IL-5 production at the transcriptional level in EL-4, a mouse lymphoma line.	Tetradecanoylphorbol Acetate	80-83	interleukin 2	Mus musculus	93-97
17321722-5	2007	Furthermore, the PKC agonist TPA promotes expression of TSG101 and keratin 10 in keratinocytes under low calcium conditions, while co-treatment with the PKC inhibitor GF 109203X blocks TPA-induced TSG101 and keratin 10 upregulation.	Tetradecanoylphorbol Acetate	185-188	keratin 10	Homo sapiens	208-218
17321722-7	2007	Here we show that both calcium and TPA activate PKC, stimulate phosphorylation of Sp1, and augment the activity of the TSG101 promoter in a manner dependent on its Sp1-binding site.	Tetradecanoylphorbol Acetate	35-38	tumor susceptibility 101	Homo sapiens	119-125
17336041-3	2007	Data in this study show that JWA, a newly identified novel microtubule-associated protein (MAP) was essential for the rearrangement of F-actin cytoskeleton and activation of MAPK cascades induced by arsenic trioxide (As2O3) and phorbol ester (PMA).	Tetradecanoylphorbol Acetate	243-246	regulator of microtubule dynamics 1	Homo sapiens	59-89
7499370-2	1995	The tyrosine kinase inhibitor herbimycin A was found to block NF-kappa B stimulation in response to interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat T lymphoma cells.	Tetradecanoylphorbol Acetate	118-149	NIN1/RPN12 binding protein 1 homolog	Mus musculus	157-162
17336041-3	2007	Data in this study show that JWA, a newly identified novel microtubule-associated protein (MAP) was essential for the rearrangement of F-actin cytoskeleton and activation of MAPK cascades induced by arsenic trioxide (As2O3) and phorbol ester (PMA).	Tetradecanoylphorbol Acetate	243-246	regulator of microtubule dynamics 1	Homo sapiens	91-94
17314023-1	2007	Long-term culture of phorbol ester (TPA)-differentiated and growth-arrested human U937 leukemia cells was associated with expression of c-jun transcription factors and vimentin intermediate filaments until the cells entered a retrodifferentiation program.	Tetradecanoylphorbol Acetate	36-39	vimentin	Homo sapiens	168-176
7595543-6	1995	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate induced interleukin-6 production, and treatment with a combination of this phorbol ester and interleukin-1 produced synergistic stimulation.	Tetradecanoylphorbol Acetate	18-54	interleukin 1 alpha	Homo sapiens	148-161
8519413-3	1995	A fragment of the ODC 5" flanking region (nt-1156 to +13) was sufficient to confer 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive expression to a luciferase reporter gene when transfected into H35 cells.	Tetradecanoylphorbol Acetate	83-119	ornithine decarboxylase 1	Rattus norvegicus	18-21
8519413-3	1995	A fragment of the ODC 5" flanking region (nt-1156 to +13) was sufficient to confer 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive expression to a luciferase reporter gene when transfected into H35 cells.	Tetradecanoylphorbol Acetate	121-124	ornithine decarboxylase 1	Rattus norvegicus	18-21
8519413-4	1995	However, induction by TPA was not observed in Rat2 fibroblasts, although refeeding of serum-starved Rat2 cells with fresh serum-containing medium rapidly induced a fivefold to sixfold increase in ODC promoter activity, maximal about 8 h after refeeding.	Tetradecanoylphorbol Acetate	22-25	ornithine decarboxylase 1	Rattus norvegicus	196-199
8519413-9	1995	Thus, we conclude that the proximal ODC promoter (nt -92 to +13) responds to TPA and serum stimulation in a cell-type-specific manner that is not mediated by canonical AP-1 elements.	Tetradecanoylphorbol Acetate	77-80	ornithine decarboxylase 1	Rattus norvegicus	36-39
17674818-7	2007	TPA enhanced lipid peroxidation with reduction in the level of catalase, glutathione, glutathione peroxidase, glutathione reductase and glutathione-s-transferase.	Tetradecanoylphorbol Acetate	0-3	hematopoietic prostaglandin D synthase	Mus musculus	136-161
17452290-8	2007	The protein kinase A (PKA) inhibitor H89 at a dose that completely blocked the PKA activator (8-br-cAMP)-induced CREB phosphorylation partially blocked the PMA-stimulated CREB phosphorylation.	Tetradecanoylphorbol Acetate	156-159	cAMP responsive element binding protein 1	Rattus norvegicus	113-117
7478524-7	1995	Among UT16 cells, most of TPA-inducible PTPase genes, PTP-1C, PTP-MEG2, P19-PTP, HPTP epsilon, and PTP-U1, did not respond to TPA.	Tetradecanoylphorbol Acetate	26-29	protein tyrosine phosphatase non-receptor type 9	Homo sapiens	62-70
7594470-5	1995	Mutation of Tyr 170 of murine CD28 to Phe abrogates the association of murine CD28 with PI3-K but does not affect the ability of murine CD28 to augment IL-2 production by Jurkat cells in response to the combination of ionomycin and PMA.	Tetradecanoylphorbol Acetate	232-235	CD28 antigen	Mus musculus	30-34
17452290-8	2007	The protein kinase A (PKA) inhibitor H89 at a dose that completely blocked the PKA activator (8-br-cAMP)-induced CREB phosphorylation partially blocked the PMA-stimulated CREB phosphorylation.	Tetradecanoylphorbol Acetate	156-159	cAMP responsive element binding protein 1	Rattus norvegicus	171-175
17210245-1	2007	We have previously reported that protein kinase C gamma (PKC-gamma) is activated by phorbol-12-myristate-13-acetate (TPA) and that this causes PKC-gamma translocation to membranes and phosphorylation of the gap junction protein, connexin 43 (Cx43).	Tetradecanoylphorbol Acetate	84-115	protein kinase C gamma	Homo sapiens	33-55
7592861-1	1995	Tracheobronchial epithelial (TBE) cells that normally do not express the squamous cell differentiation marker gene, SPR1, can be induced to produce it by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	154-190	psoriasis susceptibility 1 candidate 2	Homo sapiens	116-120
7592861-2	1995	The regulation of SPR1 gene expression by TPA occurs, in part, at the transcriptional level in primary human and monkey TBE cells.	Tetradecanoylphorbol Acetate	42-45	psoriasis susceptibility 1 candidate 2	Homo sapiens	18-22
7592861-6	1995	Overexpression of c-JUN and TPA treatment synergistically stimulate the SPR1 promoter activity by more than 40-fold.	Tetradecanoylphorbol Acetate	28-31	psoriasis susceptibility 1 candidate 2	Homo sapiens	72-76
17210245-1	2007	We have previously reported that protein kinase C gamma (PKC-gamma) is activated by phorbol-12-myristate-13-acetate (TPA) and that this causes PKC-gamma translocation to membranes and phosphorylation of the gap junction protein, connexin 43 (Cx43).	Tetradecanoylphorbol Acetate	84-115	protein kinase C gamma	Homo sapiens	57-66
7585518-4	1995	In the 293.27.2 human kidney cell line, as in hematopoietic cells of all lineages, NF-kappa B is stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 alpha (IL-1 alpha).	Tetradecanoylphorbol Acetate	149-152	interleukin 1 alpha	Homo sapiens	200-219
17210245-1	2007	We have previously reported that protein kinase C gamma (PKC-gamma) is activated by phorbol-12-myristate-13-acetate (TPA) and that this causes PKC-gamma translocation to membranes and phosphorylation of the gap junction protein, connexin 43 (Cx43).	Tetradecanoylphorbol Acetate	84-115	protein kinase C gamma	Homo sapiens	143-152
7585518-4	1995	In the 293.27.2 human kidney cell line, as in hematopoietic cells of all lineages, NF-kappa B is stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 alpha (IL-1 alpha).	Tetradecanoylphorbol Acetate	149-152	interleukin 1 alpha	Homo sapiens	221-231
17210245-1	2007	We have previously reported that protein kinase C gamma (PKC-gamma) is activated by phorbol-12-myristate-13-acetate (TPA) and that this causes PKC-gamma translocation to membranes and phosphorylation of the gap junction protein, connexin 43 (Cx43).	Tetradecanoylphorbol Acetate	117-120	protein kinase C gamma	Homo sapiens	33-55
7585518-5	1995	The response to either TNF-alpha or IL-1 alpha is synergistically enhanced by TPA.	Tetradecanoylphorbol Acetate	78-81	interleukin 1 alpha	Homo sapiens	36-46
17210245-1	2007	We have previously reported that protein kinase C gamma (PKC-gamma) is activated by phorbol-12-myristate-13-acetate (TPA) and that this causes PKC-gamma translocation to membranes and phosphorylation of the gap junction protein, connexin 43 (Cx43).	Tetradecanoylphorbol Acetate	117-120	protein kinase C gamma	Homo sapiens	57-66
17210245-1	2007	We have previously reported that protein kinase C gamma (PKC-gamma) is activated by phorbol-12-myristate-13-acetate (TPA) and that this causes PKC-gamma translocation to membranes and phosphorylation of the gap junction protein, connexin 43 (Cx43).	Tetradecanoylphorbol Acetate	117-120	protein kinase C gamma	Homo sapiens	143-152
17210245-6	2007	However, after TPA activation of the PKC-gamma, the Cx43 did not disassemble out of plaques even though the PKC-gamma enzyme was activated and the Cx43 was phosphorylated on S368.	Tetradecanoylphorbol Acetate	15-18	protein kinase C gamma	Homo sapiens	37-46
8593248-4	1995	Here we investigate the effect of well-known PKC activator 12-O-tetradecanoyl-2 phorbol-13-acetate (TPA), on the levels of 32P incorporation into EGF induced phosphatidylinositols (PI, PI4P, PI4, 5P2) and different phospholipids (PC, PA, PS) as well as on induced tyrosine kinase activity.	Tetradecanoylphorbol Acetate	100-103	epidermal growth factor	Homo sapiens	146-149
8593248-5	1995	TPA significantly decreased the effects of EGF and it had the biggest inhibitory effect on EGF induced PC level.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor	Homo sapiens	43-46
17205062-6	2007	Pyk2 is activated by treatment with keratinocyte-differentiating agents, 12-O-tetradecanoylphorbol-13-acetate and calcium via a mechanism that requires intracellular calcium release and functional protein kinase C (PKC) and Src activities.	Tetradecanoylphorbol Acetate	73-109	protein tyrosine kinase 2 beta	Homo sapiens	0-4
8593248-5	1995	TPA significantly decreased the effects of EGF and it had the biggest inhibitory effect on EGF induced PC level.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor	Homo sapiens	91-94
7589260-3	1995	To investigate the mechanism by which TPA arrests melanoma cell growth at the G1/S transition we have examined its effects on the levels of cyclins and cyclin dependent kinases (CDKs) and activation of CDK2 kinase activity.	Tetradecanoylphorbol Acetate	38-41	cyclin dependent kinase 1	Homo sapiens	178-182
7589260-4	1995	Addition of TPA in G1 blocked the increase in the level of p34cdc2 mRNA, but not of CDK2 mRNA.	Tetradecanoylphorbol Acetate	12-15	cyclin dependent kinase 1	Homo sapiens	59-66
17379255-3	2007	EGCG markedly inhibited the phorbol 12-myristate 13-acetate (PMA)-induced MCP-1 mRNA and protein levels in a dose-dependent manner.	Tetradecanoylphorbol Acetate	28-59	C-C motif chemokine ligand 2	Homo sapiens	74-79
7565762-0	1995	12-O-tetradecanoylphorbol-13-acetate activation of the MDR1 promoter is mediated by EGR1.	Tetradecanoylphorbol Acetate	0-36	early growth response 1	Homo sapiens	84-88
7565762-5	1995	TPA induced EGR1 binding to the -69/+20 promoter sequences over a time course which correlated with increased MDR1 promoter activity and increased steady-state MDR1 RNA levels.	Tetradecanoylphorbol Acetate	0-3	early growth response 1	Homo sapiens	12-16
17379255-3	2007	EGCG markedly inhibited the phorbol 12-myristate 13-acetate (PMA)-induced MCP-1 mRNA and protein levels in a dose-dependent manner.	Tetradecanoylphorbol Acetate	61-64	C-C motif chemokine ligand 2	Homo sapiens	74-79
7592595-5	1995	N-Acetylcysteine (NAC) and glutathione, as well as superoxide dismutase and catalase, inhibited both the increase in endogenous MT-1 mRNA and the activation of reporter gene activity by heme-hemopexin, CoPP-hemopexin, and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	222-253	hemopexin	Mus musculus	191-200
17430547-6	2007	Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4(+) T cells was inversely correlated with serum CRI and directly correlated with spleen size.	Tetradecanoylphorbol Acetate	11-36	interleukin 4	Mus musculus	106-110
17430547-6	2007	Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4(+) T cells was inversely correlated with serum CRI and directly correlated with spleen size.	Tetradecanoylphorbol Acetate	11-36	interleukin 5	Mus musculus	112-116
17430547-6	2007	Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4(+) T cells was inversely correlated with serum CRI and directly correlated with spleen size.	Tetradecanoylphorbol Acetate	38-41	interleukin 4	Mus musculus	106-110
17430547-6	2007	Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4(+) T cells was inversely correlated with serum CRI and directly correlated with spleen size.	Tetradecanoylphorbol Acetate	38-41	interleukin 5	Mus musculus	112-116
7575453-2	1995	Stimulation of these cells with phorbol 12-myristate 13-acetate (PMA), zymosan and lipopolysaccharide (LPS), but not with the Ca(2+)-ionophore A23187, leads to phosphorylation of cPLA2 and activation of mitogen-activated protein (MAP) kinase, supporting the hypothesis that MAP kinase is involved in cPLA2 phosphorylation.	Tetradecanoylphorbol Acetate	32-63	phospholipase A2 group IVA	Rattus norvegicus	179-184
17394101-5	2007	These results suggest that the inhibition of TPA- or UVB-induced AP-1 and NF-kappaB activity, inhibition of HL-60 cells and cancer A549 cells proliferation and induction of apoptotic in human leukemia HL-60 cancer cells may be mediated through the ERKs and MEK 1/2 signal pathway.	Tetradecanoylphorbol Acetate	45-48	mitogen-activated protein kinase kinase 1	Homo sapiens	257-264
7575453-2	1995	Stimulation of these cells with phorbol 12-myristate 13-acetate (PMA), zymosan and lipopolysaccharide (LPS), but not with the Ca(2+)-ionophore A23187, leads to phosphorylation of cPLA2 and activation of mitogen-activated protein (MAP) kinase, supporting the hypothesis that MAP kinase is involved in cPLA2 phosphorylation.	Tetradecanoylphorbol Acetate	32-63	phospholipase A2 group IVA	Rattus norvegicus	300-305
17438459-9	2007	High-dose (0.5 mg/mL) r-tPA lavage increased fibrinolysis, demonstrated by low abdominal plasminogen activator inhibitor 1 levels and elevated pulmonary tPA levels, resulting in reduced abdominal bacterial load, chemokine levels, leukocyte influx, and thrombin generation, along with less pulmonary fibrin depositions and organ damage on histological examination (P &lt; 0.05 vs. saline lavage).	Tetradecanoylphorbol Acetate	24-27	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	89-122
8774948-4	1995	Tetradecanoyl phorbol acetate (TPA; 1-1000 nmol/l) increases the concentration of proenkephalin mRNA in these cells by activating protein kinase C. The enhancement in proenkephalin mRNA caused by TPA (10 nmol/l) was not affected by the cyclooxygenase inhibitor indomethacin (5 mumol/l).	Tetradecanoylphorbol Acetate	0-29	proenkephalin	Rattus norvegicus	82-95
8774948-4	1995	Tetradecanoyl phorbol acetate (TPA; 1-1000 nmol/l) increases the concentration of proenkephalin mRNA in these cells by activating protein kinase C. The enhancement in proenkephalin mRNA caused by TPA (10 nmol/l) was not affected by the cyclooxygenase inhibitor indomethacin (5 mumol/l).	Tetradecanoylphorbol Acetate	0-29	proenkephalin	Rattus norvegicus	167-180
8774948-4	1995	Tetradecanoyl phorbol acetate (TPA; 1-1000 nmol/l) increases the concentration of proenkephalin mRNA in these cells by activating protein kinase C. The enhancement in proenkephalin mRNA caused by TPA (10 nmol/l) was not affected by the cyclooxygenase inhibitor indomethacin (5 mumol/l).	Tetradecanoylphorbol Acetate	31-34	proenkephalin	Rattus norvegicus	82-95
8774948-4	1995	Tetradecanoyl phorbol acetate (TPA; 1-1000 nmol/l) increases the concentration of proenkephalin mRNA in these cells by activating protein kinase C. The enhancement in proenkephalin mRNA caused by TPA (10 nmol/l) was not affected by the cyclooxygenase inhibitor indomethacin (5 mumol/l).	Tetradecanoylphorbol Acetate	31-34	proenkephalin	Rattus norvegicus	167-180
17299772-4	2007	Tissue type plasminogen activator (tPA) is a well-known extracellular serine protease and is involved in the modification of the extracellular matrix, which leads to neuroplastic changes such as long-term potentiation in the hippocampus.	Tetradecanoylphorbol Acetate	35-38	plasminogen activator, tissue type	Rattus norvegicus	0-33
8774948-4	1995	Tetradecanoyl phorbol acetate (TPA; 1-1000 nmol/l) increases the concentration of proenkephalin mRNA in these cells by activating protein kinase C. The enhancement in proenkephalin mRNA caused by TPA (10 nmol/l) was not affected by the cyclooxygenase inhibitor indomethacin (5 mumol/l).	Tetradecanoylphorbol Acetate	196-199	proenkephalin	Rattus norvegicus	82-95
8774948-4	1995	Tetradecanoyl phorbol acetate (TPA; 1-1000 nmol/l) increases the concentration of proenkephalin mRNA in these cells by activating protein kinase C. The enhancement in proenkephalin mRNA caused by TPA (10 nmol/l) was not affected by the cyclooxygenase inhibitor indomethacin (5 mumol/l).	Tetradecanoylphorbol Acetate	196-199	proenkephalin	Rattus norvegicus	167-180
8774948-5	1995	However, nordihydroguaiaretic acid, which blocks cyclooxygenase and lipoxygenases, potentiated the effect of TPA on proenkephalin mRNA, when used at concentrations of 0.5-50 mumol/l.	Tetradecanoylphorbol Acetate	109-112	proenkephalin	Rattus norvegicus	116-129
8774948-6	1995	Two selective inhibitors of 5-lipoxygenase, i.e. MK886 (5 mumol/l) and BAY X1005 (1 mumol/l), also enhanced the effect of TPA (10 nmol/l) without affecting the basal expression of the gene.	Tetradecanoylphorbol Acetate	122-125	arachidonate 5-lipoxygenase	Rattus norvegicus	28-42
8774948-7	1995	When added to the incubation medium, leukotriene E4 (10-1000 nmol/l) diminished in a dose-dependent manner the basal and TPA-induced expression of the proenkephalin gene.	Tetradecanoylphorbol Acetate	121-124	proenkephalin	Rattus norvegicus	151-164
17493330-5	2007	The aim of this study was to investigate the expression of MtF, transferrin receptor 1 (TfR1) and ferritin (Fn) mRNAs in K562 leukemic cells during TPA-induced cell differentiation and to explore the interrelationship between the expression levels of these iron metabolism-related molecules.	Tetradecanoylphorbol Acetate	148-151	ferritin mitochondrial	Homo sapiens	59-62
7545087-7	1995	In HDLM-2 cells, the phrobol ester phorbol 12-myristate 13-acetate also stimulated tyrosine phosphorylation of p42, and this effect was enhanced by M44.	Tetradecanoylphorbol Acetate	35-66	cyclin dependent kinase 20	Homo sapiens	111-114
17493330-9	2007	This study revealed that over 95% of K562 cells showed morphological features of monocyte/macrophage, and the expression of CD64 on cell surface increased significantly at day 5 with TPA treatment.	Tetradecanoylphorbol Acetate	183-186	Fc gamma receptor Ia	Homo sapiens	124-128
17493330-11	2007	With increase of TPA-induced cell differentiation, MtF mRNA expressions were downregulated progressively.	Tetradecanoylphorbol Acetate	17-20	ferritin mitochondrial	Homo sapiens	51-54
7553596-2	1995	The c-Fos protein is inducible by TPA and thus is associated with c-Jun to result in an increased AP-1 activity in mouse fibroblast cells.	Tetradecanoylphorbol Acetate	34-37	FBJ osteosarcoma oncogene	Mus musculus	4-9
17493330-12	2007	After 5 days of induced cell differentiation, expression levels of MtF and TfR1 mRNA were just 50.3% and 68.2% of that before TPA treatment.	Tetradecanoylphorbol Acetate	126-129	ferritin mitochondrial	Homo sapiens	67-70
7553596-4	1995	In the present study, the effects of curcumin on TPA-induced c-fos mRNA and protein levels were determined by RNA hybridization and western blot analysis, respectively.	Tetradecanoylphorbol Acetate	49-52	FBJ osteosarcoma oncogene	Mus musculus	61-66
7553596-5	1995	Curcumin decreases the TPA-induced nuclear abundance of c-Fos protein in spite of the slight super-induction of c-fos mRNA.	Tetradecanoylphorbol Acetate	23-26	FBJ osteosarcoma oncogene	Mus musculus	56-61
7553596-6	1995	Upon TPA stimulation, the amount of c-Fos in the quiescent cells increases and reaches maximum at 30 min, and then progressively disappears over a period of 60 min.	Tetradecanoylphorbol Acetate	5-8	FBJ osteosarcoma oncogene	Mus musculus	36-41
17493330-14	2007	It is concluded that MtF expression is downregulated during TPA-induced K562 cell differentiation, with concomitant downregulation of TfR1 and upregulation of Fn.	Tetradecanoylphorbol Acetate	60-63	ferritin mitochondrial	Homo sapiens	21-24
17227770-3	2007	Ser-116 --&gt; Gly (PED(S116G)) but not Ser-104 --&gt; Gly (PED(S104G)) substitution almost completely abolished TPA regulation of PED/PEA-15 expression.	Tetradecanoylphorbol Acetate	113-116	proliferation and apoptosis adaptor protein 15	Homo sapiens	135-141
7553596-7	1995	However, the c-Fos protein seems susceptible to rapid degradation by 45 min if NIH 3T3 cells were treated with TPA in the presence of curcumin.	Tetradecanoylphorbol Acetate	111-114	FBJ osteosarcoma oncogene	Mus musculus	13-18
17227770-7	2007	At variance, the proteasome inhibitor lactacystin mimicked TPA action on PED/PEA-15 intracellular accumulation and reverted the effects of PKC-zeta and CaMK inhibition.	Tetradecanoylphorbol Acetate	59-62	proliferation and apoptosis adaptor protein 15	Homo sapiens	77-83
17227770-9	2007	PED/PEA-15 ubiquitinylation was reduced by TPA and PKC-zeta overexpression and increased by KN-93 and PKC-zeta block.	Tetradecanoylphorbol Acetate	43-46	proliferation and apoptosis adaptor protein 15	Homo sapiens	4-10
17227770-12	2007	Taken together, our results indicate that TPA increases PED/PEA-15 expression at the post-translational level by inducing phosphorylation at serine 116 and preventing ubiquitinylation and proteosomal degradation.	Tetradecanoylphorbol Acetate	42-45	proliferation and apoptosis adaptor protein 15	Homo sapiens	60-66
17140607-7	2007	Intracellular application of a PKA inhibitor, protein kinase inhibitor (PKI, 0.01mM), inhibited the baseline Nav 1.8 current, significantly attenuated the 8-Br-cAMP-and PMA-induced increase in the peak Nav 1.8 current, and caused a significant increase in the slope factor of the inactivation curve.	Tetradecanoylphorbol Acetate	169-172	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	31-34
8861714-4	1995	Phorbol 12-myristate 13-acetate (10(-9) - 3 x 10(-6) M) produced a concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but enhanced nitrite accumulation when added 12 hours following stimulation with LPS and IFN-gamma.	Tetradecanoylphorbol Acetate	0-31	interferon regulatory factor 6	Homo sapiens	163-166
8861714-4	1995	Phorbol 12-myristate 13-acetate (10(-9) - 3 x 10(-6) M) produced a concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but enhanced nitrite accumulation when added 12 hours following stimulation with LPS and IFN-gamma.	Tetradecanoylphorbol Acetate	0-31	interferon regulatory factor 6	Homo sapiens	263-266
8690728-4	1995	The stimulatory effect of PMA was further enhanced in the presence of okadaic acid, but it was strongly inhibited in the presence of 0.5 microM staurosporine, an inhibitor of protein kinase C. PMA and okadaic acid also stimulated the response to heat stress of the expression of alphaB crystallin, but they barely stimulated the response to heat stress of hsp27.	Tetradecanoylphorbol Acetate	26-29	heat shock protein family B (small) member 1	Homo sapiens	356-361
8690728-4	1995	The stimulatory effect of PMA was further enhanced in the presence of okadaic acid, but it was strongly inhibited in the presence of 0.5 microM staurosporine, an inhibitor of protein kinase C. PMA and okadaic acid also stimulated the response to heat stress of the expression of alphaB crystallin, but they barely stimulated the response to heat stress of hsp27.	Tetradecanoylphorbol Acetate	193-196	heat shock protein family B (small) member 1	Homo sapiens	356-361
17334506-10	2007	As neuroserpin inhibits tissue plasminogen activator, a comparative analysis of tPA and plasminogen activator inhibitor-1 (PAI-1) expression was undertaken.	Tetradecanoylphorbol Acetate	80-83	serpin family I member 1	Homo sapiens	3-14
8690728-6	1995	The arsenite-induced release of arachidonic acid from cells was also stimulated in the presence of PMA and/or akadaic acid, and the stimulatory effects of PMA and okadaic acid on the arsenite-induced accumulation of alphaB crystallin and hsp27 were strongly suppressed by quinacrine, an inhibitor of phospholipase A2.	Tetradecanoylphorbol Acetate	155-158	heat shock protein family B (small) member 1	Homo sapiens	238-243
7643082-9	1995	The level of factors binding to the 12-O-tetradecanoylphorbol 13-acetate-responsive element (TRE) displayed a late and sustained increase preceding neuronal death, which was not found for factors complexing the Sp1 P, Oct, and USF binding sites.	Tetradecanoylphorbol Acetate	36-72	plexin A2	Homo sapiens	218-221
17379955-4	2007	Geldanamycin treatment in the presence of TPA also enhanced destabilization of Lck.	Tetradecanoylphorbol Acetate	42-45	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
7651737-0	1995	By-pass of TPA-induced differentiation and cell cycle arrest by the c-Myb DNA-binding domain.	Tetradecanoylphorbol Acetate	11-14	MYB proto-oncogene, transcription factor	Homo sapiens	68-73
7651737-1	1995	Monoblasts transformed by v-Myb can be induced to differentiate into macrophages by treatment with phorbol ester (TPA).	Tetradecanoylphorbol Acetate	114-117	MYB proto-oncogene, transcription factor	Homo sapiens	26-31
17379955-9	2007	Furthermore, inhibition of Lck in the presence of TPA induced apoptosis in thymocytes.	Tetradecanoylphorbol Acetate	50-53	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	27-30
7627957-3	1995	injection to pregnant mothers) followed by 12-O-tetradecanoylphorbol-13-acetate applications to the skin of CD1 mice, papillomas and carcinomas appeared, whereas fibrosarcomas were induced when DMBA was s.c. injected.	Tetradecanoylphorbol Acetate	43-79	CD1 antigen complex	Mus musculus	108-111
17188889-7	2007	Disruption of NET/SYN1A interaction abolished inhibition of NE transport by phorbol ester (PMA) to activate protein kinase C (PKC), but had no effect on transport inhibition by the Ca2+ calmodulin kinase (CaMK) inhibitor KN93.	Tetradecanoylphorbol Acetate	91-94	syntaxin 1A	Homo sapiens	18-23
7646466-2	1995	We have previously found that transforming growth factor-beta, type 1 (TGF-beta 1), increases uPAR gene transcription in the human lung carcinoma cell line A549 and now report that also epidermal growth factor (EGF) and the tumour promoter phorbol 12-myristate 13-acetate (PMA) cause increased uPAR transcription and that PMA and TGF-beta 1 in addition increase the stability of uPAR mRNA, while EGF has no effect on this parameter.	Tetradecanoylphorbol Acetate	240-271	plasminogen activator, urokinase receptor	Homo sapiens	94-98
17135721-5	2007	RESULTS: There were significant and negative correlations between serum 25(OH) vitamin D and PAI-1 and tPA Ag, and between serum 1,25(OH)2 vitamin D and tPA Ag and HS-CRP.	Tetradecanoylphorbol Acetate	103-106	serpin family E member 1	Homo sapiens	93-98
7646475-3	1995	Brief exposure to a calcium ionophore or phorbol 12-myristate 13-acetate (PMA) stably enhanced PLA2 activity.	Tetradecanoylphorbol Acetate	41-72	phospholipase A2 group IB	Rattus norvegicus	95-99
7646475-3	1995	Brief exposure to a calcium ionophore or phorbol 12-myristate 13-acetate (PMA) stably enhanced PLA2 activity.	Tetradecanoylphorbol Acetate	74-77	phospholipase A2 group IB	Rattus norvegicus	95-99
7642554-2	1995	Within minutes of phorbol 12-myristate 13-acetate treatment, epidermal growth factor receptor and HER2 tyrosine phosphorylation was decreased, while platelet-derived growth factor receptor and insulin receptor autophosphorylation was upregulated.	Tetradecanoylphorbol Acetate	18-49	epidermal growth factor receptor	Mus musculus	61-93
7642554-2	1995	Within minutes of phorbol 12-myristate 13-acetate treatment, epidermal growth factor receptor and HER2 tyrosine phosphorylation was decreased, while platelet-derived growth factor receptor and insulin receptor autophosphorylation was upregulated.	Tetradecanoylphorbol Acetate	18-49	erb-b2 receptor tyrosine kinase 2	Mus musculus	98-102
16774932-4	2007	The use of Ro-318220 and GO-6983, general PKC inhibitors as well as MG-132, a proteasome-specific inhibitor, abrogated PMA-induced degradation of IKK-gamma and recovered the activation of IKK by TNF, suggesting that IKK complex is predominantly degraded by the proteasome pathway in a PKC-dependent manner.	Tetradecanoylphorbol Acetate	119-122	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	146-155
16774932-5	2007	We also found that IKK-gamma strongly associates with heat shock protein 90 (Hsp90) in HCT-116 cells, and that this interaction was dramatically reduced after exposure to PMA.	Tetradecanoylphorbol Acetate	171-174	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	19-28
16774932-5	2007	We also found that IKK-gamma strongly associates with heat shock protein 90 (Hsp90) in HCT-116 cells, and that this interaction was dramatically reduced after exposure to PMA.	Tetradecanoylphorbol Acetate	171-174	heat shock protein 90 alpha family class A member 1	Homo sapiens	54-75
16774932-5	2007	We also found that IKK-gamma strongly associates with heat shock protein 90 (Hsp90) in HCT-116 cells, and that this interaction was dramatically reduced after exposure to PMA.	Tetradecanoylphorbol Acetate	171-174	heat shock protein 90 alpha family class A member 1	Homo sapiens	77-82
7644539-0	1995	The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression.	Tetradecanoylphorbol Acetate	30-66	C-C motif chemokine ligand 2	Homo sapiens	123-153
16850528-5	2007	The PKC-activating phorbol-12-myristate-13-acetate (PMA), differently from LDL, enhanced the LDL-receptor (LDL-R)-mediated binding and degradation of [125I]LDL, but inhibited endogenous cholesterol synthesis, and both effects were inhibited by H-7.	Tetradecanoylphorbol Acetate	19-50	low density lipoprotein receptor	Homo sapiens	93-105
7627704-3	1995	As markers of endothelial cell dysfunction, levels of von Willebrand factor (vWF), tissue-type plasminogen activator-plasminogen activator inhibitor-1 (TPA-PAI-1) complex, PAI-1, and tissue factor pathway inhibitor (TFPI) were measured.	Tetradecanoylphorbol Acetate	152-155	serpin family E member 1	Homo sapiens	156-161
7627704-7	1995	This group also had higher levels of endothelial cell-derived factors (vWF, TPA-PAI-1 complex, and PAI-1) than the control group.	Tetradecanoylphorbol Acetate	76-79	serpin family E member 1	Homo sapiens	80-85
16850528-5	2007	The PKC-activating phorbol-12-myristate-13-acetate (PMA), differently from LDL, enhanced the LDL-receptor (LDL-R)-mediated binding and degradation of [125I]LDL, but inhibited endogenous cholesterol synthesis, and both effects were inhibited by H-7.	Tetradecanoylphorbol Acetate	19-50	low density lipoprotein receptor	Homo sapiens	107-112
16850528-5	2007	The PKC-activating phorbol-12-myristate-13-acetate (PMA), differently from LDL, enhanced the LDL-receptor (LDL-R)-mediated binding and degradation of [125I]LDL, but inhibited endogenous cholesterol synthesis, and both effects were inhibited by H-7.	Tetradecanoylphorbol Acetate	52-55	low density lipoprotein receptor	Homo sapiens	93-105
7616276-7	1995	Interstitial collagenase, gelatinase B, stromelysin, and TIMP-1 genes were upregulated in many cell lines by phorbol-12-myristate-13-acetate (PMA) and in some cell lines by epidermal growth factor, tumor necrosis factor-alpha, or interleukin-1 beta.	Tetradecanoylphorbol Acetate	109-140	matrix metallopeptidase 1	Homo sapiens	0-24
16850528-5	2007	The PKC-activating phorbol-12-myristate-13-acetate (PMA), differently from LDL, enhanced the LDL-receptor (LDL-R)-mediated binding and degradation of [125I]LDL, but inhibited endogenous cholesterol synthesis, and both effects were inhibited by H-7.	Tetradecanoylphorbol Acetate	52-55	low density lipoprotein receptor	Homo sapiens	107-112
7616276-7	1995	Interstitial collagenase, gelatinase B, stromelysin, and TIMP-1 genes were upregulated in many cell lines by phorbol-12-myristate-13-acetate (PMA) and in some cell lines by epidermal growth factor, tumor necrosis factor-alpha, or interleukin-1 beta.	Tetradecanoylphorbol Acetate	142-145	matrix metallopeptidase 1	Homo sapiens	0-24
17416972-11	2007	We also observed that PKC inhibitor H-7 or prolonged pretreatment with TPA can rapidly increase AQP4 expression (p&lt;0.05).	Tetradecanoylphorbol Acetate	71-74	aquaporin 4	Rattus norvegicus	96-100
7676402-3	1995	Tissue factor (TF) can be induced in response to stimulation with tumor necrosis factor alpha (TNF-alpha), interleukin-1 alpha (IL-1alpha) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	143-174	coagulation factor III, tissue factor	Homo sapiens	0-13
7676402-3	1995	Tissue factor (TF) can be induced in response to stimulation with tumor necrosis factor alpha (TNF-alpha), interleukin-1 alpha (IL-1alpha) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	143-174	coagulation factor III, tissue factor	Homo sapiens	15-17
17065146-3	2006	Moreover, enhancement of Egr-1 protein with phorbol 12-myristate 13-acetate or an egr-1 expression vector rescued BKS-2 cells from BCR signal-induced growth inhibition.	Tetradecanoylphorbol Acetate	44-75	early growth response 1	Homo sapiens	25-30
7604037-8	1995	In addition, both the tumor promoter okadaic acid (which inhibits protein phosphatases 1 and 2A) and phorbol ester (phorbol 12-tetradecanoate 13-acetate) stimulate phosphorylation of p33, p54, and low molecular mass histones.	Tetradecanoylphorbol Acetate	116-152	lymphotoxin beta	Homo sapiens	183-186
7547506-2	1995	Prolonged treatment of RD cells with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induces growth arrest and myogenic differentiation as shown by the accumulation of alpha-actin and myosin light and heavy chains, without affecting the expression of MyoD and myogenin.	Tetradecanoylphorbol Acetate	112-115	myosin heavy chain 14	Homo sapiens	216-222
17062574-3	2006	Overexpression of DSCR1.4 significantly attenuated the induction of cyclooxygenase-2 (COX-2) expression by phorbol 12-myristate 13-acetate (PMA) via a calcineurin-independent mechanism.	Tetradecanoylphorbol Acetate	107-138	regulator of calcineurin 1	Homo sapiens	18-23
21153207-8	1995	The effect of hIL-3 on the enhancement of oIFNtau productionin vitro could be mimicked by the addition of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	106-137	interleukin 3	Homo sapiens	14-19
21153207-8	1995	The effect of hIL-3 on the enhancement of oIFNtau productionin vitro could be mimicked by the addition of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	139-142	interleukin 3	Homo sapiens	14-19
7558122-8	1995	When splenocytes were stimulated with Con A for 4 days in the presence of IL-4, and restimulated with PMA and ionomycin, IFN-gamma secretion was greatly suppressed.	Tetradecanoylphorbol Acetate	102-105	interferon gamma	Rattus norvegicus	121-130
17062574-3	2006	Overexpression of DSCR1.4 significantly attenuated the induction of cyclooxygenase-2 (COX-2) expression by phorbol 12-myristate 13-acetate (PMA) via a calcineurin-independent mechanism.	Tetradecanoylphorbol Acetate	140-143	regulator of calcineurin 1	Homo sapiens	18-23
16917081-5	2006	Both inhibitors suppressed in transiently transfected Jurkat T lymphocytes the gal-1-induced expression of the luciferase (luc) reporter gene constructs pNFAT-TA-Luc and pAP1(phorbol-12-myristate-13-acetate [PMA])-TA-Luc.	Tetradecanoylphorbol Acetate	175-206	galectin 1	Homo sapiens	79-84
8530162-8	1995	Moreover, DIF activation was observed during TPA-induced monocytic differentiation and after treatment of macrophages with the macrophage differentiation factor CSF-1.	Tetradecanoylphorbol Acetate	45-48	colony stimulating factor 1	Homo sapiens	161-166
16917081-5	2006	Both inhibitors suppressed in transiently transfected Jurkat T lymphocytes the gal-1-induced expression of the luciferase (luc) reporter gene constructs pNFAT-TA-Luc and pAP1(phorbol-12-myristate-13-acetate [PMA])-TA-Luc.	Tetradecanoylphorbol Acetate	175-206	regenerating family member 3 alpha	Homo sapiens	170-174
7473875-6	1995	At the peak of TPA-induced potentiation, dose-response relations suggested an increased binding affinity of nAChR for the neurotransmitter.	Tetradecanoylphorbol Acetate	15-18	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	108-113
7473875-9	1995	The nAChR-channel activity in cell-attached patches increased when TPA was applied to the oocytes.	Tetradecanoylphorbol Acetate	67-70	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	4-9
8641331-4	1996	Nuclear run-on experiments revealed that the inhibitory effect of db-cAMP could partially be ascribed to a five-fold reduction in transcription rate of both the IL-3 and GM-CSF gene in the presence of Con A or Con A plus PMA.	Tetradecanoylphorbol Acetate	221-224	interleukin 3	Homo sapiens	161-165
8641331-4	1996	Nuclear run-on experiments revealed that the inhibitory effect of db-cAMP could partially be ascribed to a five-fold reduction in transcription rate of both the IL-3 and GM-CSF gene in the presence of Con A or Con A plus PMA.	Tetradecanoylphorbol Acetate	221-224	colony stimulating factor 2	Homo sapiens	170-176
8596491-6	1996	These results suggest that TPA, an activator of PKC, has a stimulatory effect on GRH-induced cAMP production and that, finally, TRH- and CRH-induced PKC activation may cause greater secretion of GH by enhancement of cAMP production in human GH-hypersecreting adenoma cells.	Tetradecanoylphorbol Acetate	27-30	corticotropin releasing hormone	Homo sapiens	137-140
16917081-5	2006	Both inhibitors suppressed in transiently transfected Jurkat T lymphocytes the gal-1-induced expression of the luciferase (luc) reporter gene constructs pNFAT-TA-Luc and pAP1(phorbol-12-myristate-13-acetate [PMA])-TA-Luc.	Tetradecanoylphorbol Acetate	208-211	galectin 1	Homo sapiens	79-84
16995904-2	2006	OBJECTIVES: We studied Galphaq promoter activity using luciferase reporter gene assays in human erythroleukemia (HEL) cells treated with phorbol 12-myristate 13-acetate (PMA) for 24 h to induce megakaryocytic transformation.	Tetradecanoylphorbol Acetate	137-168	G protein subunit alpha q	Homo sapiens	23-30
9244191-5	1996	However, the addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) led to a rapid and transient rise in HB-EGF mRNA level.	Tetradecanoylphorbol Acetate	25-61	heparin binding EGF like growth factor	Homo sapiens	105-111
9244191-5	1996	However, the addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) led to a rapid and transient rise in HB-EGF mRNA level.	Tetradecanoylphorbol Acetate	63-66	heparin binding EGF like growth factor	Homo sapiens	105-111
9244191-6	1996	HB-EGF in Mahlavu cells appears to be regulated by a protein kinase C (PKC) pathway, since PKC inhibitors, H7, staurosporin, and calphostin C, abrogated the induction of HB-EGF mRNA by TPA.	Tetradecanoylphorbol Acetate	185-188	heparin binding EGF like growth factor	Homo sapiens	0-6
9244191-7	1996	Unlike vascular smooth muscle cells, induction of HB-EGF gene transcription by TPA was blocked completely by incubation with cycloheximide, suggesting that protein synthesis may be a prerequisite for HB-EGF gene transcription in Mahlavu cells.	Tetradecanoylphorbol Acetate	79-82	heparin binding EGF like growth factor	Homo sapiens	50-56
7541446-5	1995	Treatment with interferon-beta (IFN-beta), platelet-derived growth factor-AA, leukemia inhibitory factor, phorbol 12-myristate 13-acetate, and dibutyryl cyclic AMP stimulated phosphorylation of HSP27 moderately, while IFN-gamma, TNF-beta, basic fibroblast growth factor, epidermal growth factor, or fetal bovine serum did not significantly alter the level of HSP27 phosphorylation.	Tetradecanoylphorbol Acetate	106-137	heat shock protein family B (small) member 1	Homo sapiens	194-199
7541446-5	1995	Treatment with interferon-beta (IFN-beta), platelet-derived growth factor-AA, leukemia inhibitory factor, phorbol 12-myristate 13-acetate, and dibutyryl cyclic AMP stimulated phosphorylation of HSP27 moderately, while IFN-gamma, TNF-beta, basic fibroblast growth factor, epidermal growth factor, or fetal bovine serum did not significantly alter the level of HSP27 phosphorylation.	Tetradecanoylphorbol Acetate	106-137	heat shock protein family B (small) member 1	Homo sapiens	359-364
9084655-10	1996	It is concluded that HL-60 cells induced to differentiate with the combination of TPA and 1,25-vit D3 can be utilised as a model system to delineate structural requirements involved in the interaction between osteopontin and the alpha v beta 3 integrin.	Tetradecanoylphorbol Acetate	82-85	secreted phosphoprotein 1	Homo sapiens	209-220
16995904-2	2006	OBJECTIVES: We studied Galphaq promoter activity using luciferase reporter gene assays in human erythroleukemia (HEL) cells treated with phorbol 12-myristate 13-acetate (PMA) for 24 h to induce megakaryocytic transformation.	Tetradecanoylphorbol Acetate	170-173	G protein subunit alpha q	Homo sapiens	23-30
8695223-7	1996	Treatment of TPA with 10 microM apigenin inhibited TPA-induced C-FOS expression.	Tetradecanoylphorbol Acetate	13-16	FBJ osteosarcoma oncogene	Mus musculus	63-68
7480806-3	1995	On the other hand, phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, and sulprostone, an agonist for the PGE2 receptor EP1/EP3 subtypes, had no effect.	Tetradecanoylphorbol Acetate	52-55	prostaglandin E receptor 1	Homo sapiens	142-145
17438683-9	2006	The levels of IL-10, and especially IL-2 were elevated by TPA, but they were markedly lower than that in control group after PD098059 pretreatment.	Tetradecanoylphorbol Acetate	58-61	interleukin 2	Mus musculus	36-40
8695223-7	1996	Treatment of TPA with 10 microM apigenin inhibited TPA-induced C-FOS expression.	Tetradecanoylphorbol Acetate	51-54	FBJ osteosarcoma oncogene	Mus musculus	63-68
7770465-8	1995	Furthermore, JCA-1 cells treated with TPA acquired the expression of cytokeratin 18 and increased the expression of actin and vimentin by 300%.	Tetradecanoylphorbol Acetate	38-41	keratin 18	Homo sapiens	69-83
17438683-12	2006	TPA and A23187 can markedly rectify the disturbance of IL-2/IL-10 secretion ratio by increasing the IL-2 secretion after scald.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Mus musculus	55-59
7770465-8	1995	Furthermore, JCA-1 cells treated with TPA acquired the expression of cytokeratin 18 and increased the expression of actin and vimentin by 300%.	Tetradecanoylphorbol Acetate	38-41	vimentin	Homo sapiens	126-134
8566084-6	1996	Pre-activation of B cells with phorbol 12-myristate 13-acetate, which increased CD5 expression, failed to alter the proliferative response of CD5+ B cells to anti-mu and IL-2 with or without addition of anti-CD5 mAb.	Tetradecanoylphorbol Acetate	31-62	CD5 molecule	Homo sapiens	80-83
17438683-12	2006	TPA and A23187 can markedly rectify the disturbance of IL-2/IL-10 secretion ratio by increasing the IL-2 secretion after scald.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Mus musculus	100-104
17082637-3	2006	In this study, we report that TNF-alpha stimulates the expression of the FRA-1 protooncogene in human pulmonary epithelial cells using c-Jun, acting via a 12-O-tetradecanoylphorbol-13 acetate response element located at -318.	Tetradecanoylphorbol Acetate	155-191	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	73-78
8557761-4	1996	Phorbol 12-myristate 13-acetate (PMA) stimulated IGFBP-1 up to fourfold with a maximal effect in short-term culture.	Tetradecanoylphorbol Acetate	0-31	insulin-like growth factor binding protein 1	Rattus norvegicus	49-56
8557761-4	1996	Phorbol 12-myristate 13-acetate (PMA) stimulated IGFBP-1 up to fourfold with a maximal effect in short-term culture.	Tetradecanoylphorbol Acetate	33-36	insulin-like growth factor binding protein 1	Rattus norvegicus	49-56
8557761-6	1996	Under basal conditions IGFBP-1 production was linearly related to cell density: however, stimulation by dexamethasone was greatest in confluent cells, and PMA had a greater effect in sparse cultures.	Tetradecanoylphorbol Acetate	155-158	insulin-like growth factor binding protein 1	Rattus norvegicus	23-30
8557761-9	1996	PMA abolished the inhibitory action of insulin on IGFBP-1 secretion and mRNA expression during incubation periods of less than 4 h and not during longer incubations.	Tetradecanoylphorbol Acetate	0-3	insulin-like growth factor binding protein 1	Rattus norvegicus	50-57
7744871-8	1995	The results indicate that the specific binding of ATF3/Jun and a previously uncharacterized factor account for signal-specific transcription in response to EGF or an activated Ha-ras gene in a cell type in which the cooperative action of an activated Ha-ras gene and 12-O-tetradecanoylphorbol-13-acetate cause tumor growth.	Tetradecanoylphorbol Acetate	267-303	epidermal growth factor	Mus musculus	156-159
7761103-9	1995	The negative effect on Src kinase activity upon FGFR stimulation was mimicked by activation of PKC in FGFR-1/PAE or CCL 39 cells using phorbol 12-myristate 13-acetate (PMA) and Src was phosphorylated in vitro by purified recombinant PKC alpha.	Tetradecanoylphorbol Acetate	135-166	fibroblast growth factor receptor 1	Cricetulus griseus	102-108
7761103-9	1995	The negative effect on Src kinase activity upon FGFR stimulation was mimicked by activation of PKC in FGFR-1/PAE or CCL 39 cells using phorbol 12-myristate 13-acetate (PMA) and Src was phosphorylated in vitro by purified recombinant PKC alpha.	Tetradecanoylphorbol Acetate	168-171	fibroblast growth factor receptor 1	Cricetulus griseus	102-108
7730629-1	1995	cAMP inhibits PMA-induced IL-2 production at the transcriptional level in EL-4, a mouse lymphoma line.	Tetradecanoylphorbol Acetate	14-17	interleukin 2	Mus musculus	26-30
8642043-6	1996	7-Hydroxycoumarin decreased the relative amount of intracellular p21ras, and concomitantly a PMA-induced decrease of p21ras GTPase activity could be partially antagonized by 7-hydroxycoumarin.	Tetradecanoylphorbol Acetate	93-96	HRas proto-oncogene, GTPase	Homo sapiens	65-71
8642043-6	1996	7-Hydroxycoumarin decreased the relative amount of intracellular p21ras, and concomitantly a PMA-induced decrease of p21ras GTPase activity could be partially antagonized by 7-hydroxycoumarin.	Tetradecanoylphorbol Acetate	93-96	H3 histone pseudogene 16	Homo sapiens	65-68
8558060-7	1996	Protein kinase C (PKC) and protein tyrosine kinase (PTK) inhibition essentially abolished both PMA-induced TNF-alpha protein secretion and collagenase mRNA expression.	Tetradecanoylphorbol Acetate	95-98	protein tyrosine kinase 2 beta	Homo sapiens	52-55
8569182-6	1996	The level of paxillin phosphorylation correlated well with the degree of morphologic change induced by low-dose TPA, and the dephosphorylation occurred before reversion of morphology upon removal of TPA.	Tetradecanoylphorbol Acetate	112-115	paxillin	Homo sapiens	13-21
16950767-3	2006	We report that COX-2 expression is up-regulated in phorbol ester (phorbol myristate acetate, PMA)-differentiated human U937 macrophage-like cells stimulated with lipopolysaccharide (LPS), whereas COX-1 is not up-regulated.	Tetradecanoylphorbol Acetate	66-91	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	196-201
8569182-6	1996	The level of paxillin phosphorylation correlated well with the degree of morphologic change induced by low-dose TPA, and the dephosphorylation occurred before reversion of morphology upon removal of TPA.	Tetradecanoylphorbol Acetate	199-202	paxillin	Homo sapiens	13-21
8569182-7	1996	These findings suggest that the TPA signal was transduced to the tyrosine phosphorylation of paxillin strongly associated with formation of focal adhesion, and that this in turn induced dysfunction of the cadherin system and caused spreading and disorganization of the tubular structure.	Tetradecanoylphorbol Acetate	32-35	paxillin	Homo sapiens	93-101
7730629-4	1995	The IL-2 promoter carrying mutations in each element reduced response to PMA while it retained sensitivity to cAMP, thereby suggesting that multiple elements contribute to positive and negative responses to PMA and cAMP, respectively.	Tetradecanoylphorbol Acetate	73-76	interleukin 2	Mus musculus	4-8
16950767-3	2006	We report that COX-2 expression is up-regulated in phorbol ester (phorbol myristate acetate, PMA)-differentiated human U937 macrophage-like cells stimulated with lipopolysaccharide (LPS), whereas COX-1 is not up-regulated.	Tetradecanoylphorbol Acetate	93-96	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	196-201
8838143-1	1996	Treatment of GT1-7 neuronal cells with the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), inhibits GnRH gene transcription.	Tetradecanoylphorbol Acetate	58-95	gonadotropin releasing hormone 1	Rattus norvegicus	112-116
17035302-4	2006	PMA also activates protein kinase C (PKC).	Tetradecanoylphorbol Acetate	0-3	protein kinase C epsilon	Homo sapiens	37-40
8838143-1	1996	Treatment of GT1-7 neuronal cells with the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), inhibits GnRH gene transcription.	Tetradecanoylphorbol Acetate	97-100	gonadotropin releasing hormone 1	Rattus norvegicus	112-116
8838143-6	1996	Deletion analysis mapped the region that mediates repression by AP-1 to the area between -126 and -73 base pairs (bp) of the rGnRH 5"-flanking region: the same area that mediates TPA-induced repression and contains an imperfect TPA response element sequence at -99.	Tetradecanoylphorbol Acetate	179-182	gonadotropin releasing hormone 1	Rattus norvegicus	125-130
8838143-6	1996	Deletion analysis mapped the region that mediates repression by AP-1 to the area between -126 and -73 base pairs (bp) of the rGnRH 5"-flanking region: the same area that mediates TPA-induced repression and contains an imperfect TPA response element sequence at -99.	Tetradecanoylphorbol Acetate	228-231	gonadotropin releasing hormone 1	Rattus norvegicus	125-130
7744747-2	1995	To elucidate the physiological implication of this finding, the effects of phorbol 12-myristate 13-acetate (PMA) on PNMT promoter activity and Egr-1 expression were examined.	Tetradecanoylphorbol Acetate	75-106	phenylethanolamine-N-methyltransferase	Rattus norvegicus	116-120
7744747-2	1995	To elucidate the physiological implication of this finding, the effects of phorbol 12-myristate 13-acetate (PMA) on PNMT promoter activity and Egr-1 expression were examined.	Tetradecanoylphorbol Acetate	108-111	phenylethanolamine-N-methyltransferase	Rattus norvegicus	116-120
12595919-27	1995	Mice administered BCP/TPA developed application site lesions including scaling/crusts, ulceration, and irritation; the incidences of these lesions were similar to those in the initiator/promoter control (DMBA/TPA) /TPA) groups.	Tetradecanoylphorbol Acetate	209-212	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	Mus musculus	18-21
16950788-4	2006	RGS2 was also up-regulated by extracellular ATP, which selectively activates G(q), as well as by forskolin and phorbol myristate acetate, which activate targets downstream of G(s) and G(q), respectively.	Tetradecanoylphorbol Acetate	111-136	regulator of G-protein signaling 2	Mus musculus	0-4
12595919-27	1995	Mice administered BCP/TPA developed application site lesions including scaling/crusts, ulceration, and irritation; the incidences of these lesions were similar to those in the initiator/promoter control (DMBA/TPA) /TPA) groups.	Tetradecanoylphorbol Acetate	209-212	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	Mus musculus	18-21
12595919-30	1995	However, the incidences of papillomas in mice administered BCP/TPA were lower than those in mice administered TPA/TPA (males, 16/50; females, 16/50) and were much lower than those in DMBA/TPA mice (males, 40/50; females, 48/50).	Tetradecanoylphorbol Acetate	63-66	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	Mus musculus	59-62
8710683-3	1996	Cell-conditioned media (CM) from EL-4 cells treated with 0.2 ng/ml phorbol myristate acetate (PMA) + 0.1 microgram/ml VES contained increased amounts of IL-2, as determined by the murine cytotoxic T cell IL-2-dependent CTLL-2 bioassay.	Tetradecanoylphorbol Acetate	67-92	interleukin 2	Mus musculus	153-157
8710683-3	1996	Cell-conditioned media (CM) from EL-4 cells treated with 0.2 ng/ml phorbol myristate acetate (PMA) + 0.1 microgram/ml VES contained increased amounts of IL-2, as determined by the murine cytotoxic T cell IL-2-dependent CTLL-2 bioassay.	Tetradecanoylphorbol Acetate	67-92	interleukin 2	Mus musculus	204-208
8710683-3	1996	Cell-conditioned media (CM) from EL-4 cells treated with 0.2 ng/ml phorbol myristate acetate (PMA) + 0.1 microgram/ml VES contained increased amounts of IL-2, as determined by the murine cytotoxic T cell IL-2-dependent CTLL-2 bioassay.	Tetradecanoylphorbol Acetate	94-97	interleukin 2	Mus musculus	153-157
8710683-3	1996	Cell-conditioned media (CM) from EL-4 cells treated with 0.2 ng/ml phorbol myristate acetate (PMA) + 0.1 microgram/ml VES contained increased amounts of IL-2, as determined by the murine cytotoxic T cell IL-2-dependent CTLL-2 bioassay.	Tetradecanoylphorbol Acetate	94-97	interleukin 2	Mus musculus	204-208
8895200-7	1996	TPA initially induced translocation of PKCs alpha and delta, and to a lesser extent, PKC epsilon to the membrane fraction; 8 h after TPA treatment, differential effects on downregulation of PKCs alpha and delta were observed between cell lines, although PKC epsilon was not reduced in either cell line.	Tetradecanoylphorbol Acetate	0-3	protein kinase C epsilon	Homo sapiens	85-96
8895200-7	1996	TPA initially induced translocation of PKCs alpha and delta, and to a lesser extent, PKC epsilon to the membrane fraction; 8 h after TPA treatment, differential effects on downregulation of PKCs alpha and delta were observed between cell lines, although PKC epsilon was not reduced in either cell line.	Tetradecanoylphorbol Acetate	0-3	protein kinase C epsilon	Homo sapiens	254-265
7618260-7	1995	Similarly, Con A/phorbol myristate acetate (PMA) stimulated non-adherent (NA-) peripheral blood mononuclear cells (PBMC) from FIV infected cats synthesized less TNF-alpha than similarly treated NA-PBMC from uninfected cats.	Tetradecanoylphorbol Acetate	17-42	tumor necrosis factor	Felis catus	161-170
7618260-7	1995	Similarly, Con A/phorbol myristate acetate (PMA) stimulated non-adherent (NA-) peripheral blood mononuclear cells (PBMC) from FIV infected cats synthesized less TNF-alpha than similarly treated NA-PBMC from uninfected cats.	Tetradecanoylphorbol Acetate	44-47	tumor necrosis factor	Felis catus	161-170
16890203-0	2006	Inhibition of the TPA-induced cutaneous inflammation and hyperplasia by EC-SOD.	Tetradecanoylphorbol Acetate	18-21	superoxide dismutase 3, extracellular	Mus musculus	72-78
8530489-5	1995	The presence of EGFRvIII suppresses activation of p42 and p44 MAP kinases by phorbol 12-myristate 13-acetate (PMA) and serum; however, MEK activation by PMA is not suppressed by EGFRvIII.	Tetradecanoylphorbol Acetate	77-108	cyclin dependent kinase 20	Homo sapiens	50-53
8530489-5	1995	The presence of EGFRvIII suppresses activation of p42 and p44 MAP kinases by phorbol 12-myristate 13-acetate (PMA) and serum; however, MEK activation by PMA is not suppressed by EGFRvIII.	Tetradecanoylphorbol Acetate	110-113	cyclin dependent kinase 20	Homo sapiens	50-53
7794813-6	1995	The TPA treatment of the U-2 OS cells also induced changes typical for maturing bone cells, such as increased expression levels of alkaline phosphatase and osteopontin.	Tetradecanoylphorbol Acetate	4-7	secreted phosphoprotein 1	Homo sapiens	156-167
16890203-1	2006	This study reports the roles of extracellular superoxide dismutase (EC-SOD) in the cutaneous inflammation and hyperplasia with 12-O-tetradecanoylphorbol-3-acetate (TPA) application in EC-SOD transgenic mice (Tg EC-SOD).	Tetradecanoylphorbol Acetate	164-167	superoxide dismutase 3, extracellular	Mus musculus	32-66
16890203-1	2006	This study reports the roles of extracellular superoxide dismutase (EC-SOD) in the cutaneous inflammation and hyperplasia with 12-O-tetradecanoylphorbol-3-acetate (TPA) application in EC-SOD transgenic mice (Tg EC-SOD).	Tetradecanoylphorbol Acetate	164-167	superoxide dismutase 3, extracellular	Mus musculus	184-190
8748696-4	1995	A 180 day exposure significantly suppressed the generation of IL-2 by either concanavalin A or phorbol myristate acetate/calcium ionophore stimulation, and reduced the lectin-induced proliferation of splenic T cells.	Tetradecanoylphorbol Acetate	95-120	interleukin 2	Rattus norvegicus	62-66
16890203-1	2006	This study reports the roles of extracellular superoxide dismutase (EC-SOD) in the cutaneous inflammation and hyperplasia with 12-O-tetradecanoylphorbol-3-acetate (TPA) application in EC-SOD transgenic mice (Tg EC-SOD).	Tetradecanoylphorbol Acetate	164-167	superoxide dismutase 3, extracellular	Mus musculus	184-190
8547036-5	1995	In response to stimulation with phorbol-12-myristate-13 acetate (PMA), the 16T(-) cells produced more IL-4 and IFN-gamma, whereas the 35T(-) and MH-1 cells exhibited increased secretion of IFN-gamma, but still no IL-4 or IL-4 mRNA production.	Tetradecanoylphorbol Acetate	65-68	interleukin 4	Mus musculus	213-217
16890203-3	2006	These changes were markedly suppressed in TPA-treated Tg EC-SOD.	Tetradecanoylphorbol Acetate	42-45	superoxide dismutase 3, extracellular	Mus musculus	57-63
9049321-2	1995	Investigations into regulation of the promoter, Zp for the BZLF1 gene in B cells have identified 12-O-tetradecanoylphorbol 13-acetate, anti-immunoglobulin and Zta responsive elements as well as a negative regulatory element within Zp.	Tetradecanoylphorbol Acetate	97-133	protein Zta	Human gammaherpesvirus 4	59-64
16890203-4	2006	The expressions of the inflammatory cytokines, IL-1alpha and IL-1beta, were reduced in the TPA-treated Tg EC-SOD compared with those in TPA-treated WT.	Tetradecanoylphorbol Acetate	91-94	interleukin 1 alpha	Mus musculus	47-56
8581878-4	1995	Inhibition of protein kinase C activity by pretreatment with 1 microM chelerythrine chloride or by prolonged stimulation with 50 ng/ml tetradecanoyl phorbol acetate (TPA) partially diminished the induction of Egr-1 by EGF.	Tetradecanoylphorbol Acetate	135-164	early growth response 1	Mus musculus	209-214
16890203-4	2006	The expressions of the inflammatory cytokines, IL-1alpha and IL-1beta, were reduced in the TPA-treated Tg EC-SOD compared with those in TPA-treated WT.	Tetradecanoylphorbol Acetate	91-94	superoxide dismutase 3, extracellular	Mus musculus	106-112
8581878-4	1995	Inhibition of protein kinase C activity by pretreatment with 1 microM chelerythrine chloride or by prolonged stimulation with 50 ng/ml tetradecanoyl phorbol acetate (TPA) partially diminished the induction of Egr-1 by EGF.	Tetradecanoylphorbol Acetate	135-164	epidermal growth factor	Mus musculus	218-221
7734403-4	1995	The RNA for CYP 1A1 was dramatically and completely induced within 2 hours after exposure of immortalized granulosa cells to 3-methyl-cholanthrene (3MC) and expression could be inhibited with 10 microM phorbol myristate acetate.	Tetradecanoylphorbol Acetate	202-227	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	12-19
8581878-4	1995	Inhibition of protein kinase C activity by pretreatment with 1 microM chelerythrine chloride or by prolonged stimulation with 50 ng/ml tetradecanoyl phorbol acetate (TPA) partially diminished the induction of Egr-1 by EGF.	Tetradecanoylphorbol Acetate	166-169	early growth response 1	Mus musculus	209-214
16890203-4	2006	The expressions of the inflammatory cytokines, IL-1alpha and IL-1beta, were reduced in the TPA-treated Tg EC-SOD compared with those in TPA-treated WT.	Tetradecanoylphorbol Acetate	136-139	superoxide dismutase 3, extracellular	Mus musculus	106-112
8581878-4	1995	Inhibition of protein kinase C activity by pretreatment with 1 microM chelerythrine chloride or by prolonged stimulation with 50 ng/ml tetradecanoyl phorbol acetate (TPA) partially diminished the induction of Egr-1 by EGF.	Tetradecanoylphorbol Acetate	166-169	epidermal growth factor	Mus musculus	218-221
16890203-5	2006	The expression of IL-1alpha was significantly increased in the skin of TPA-treated WT, especially in the basal and suprabasal layers, but it was restricted focally in basal layer of the skin of TPA-treated Tg EC-SOD.	Tetradecanoylphorbol Acetate	71-74	interleukin 1 alpha	Mus musculus	18-27
7536860-7	1995	The response to the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate stimulation of the phosphorylation of CK 8 and CK 18 was also elicited in contrast to control hepatocytes.	Tetradecanoylphorbol Acetate	35-72	keratin 8	Mus musculus	111-115
16890203-5	2006	The expression of IL-1alpha was significantly increased in the skin of TPA-treated WT, especially in the basal and suprabasal layers, but it was restricted focally in basal layer of the skin of TPA-treated Tg EC-SOD.	Tetradecanoylphorbol Acetate	194-197	interleukin 1 alpha	Mus musculus	18-27
8745576-1	1995	Cardiomyocytes isolated from neonatal rats were treated with phorbol-12-myristate-13-acetate (PMA) ranging from 10(-11) to 10(-7) mol/L for 20 min, causing cytosol protein kinase A (PKA) activity to decrease while particulate PKA activity increase in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	61-92	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	164-180
16890203-5	2006	The expression of IL-1alpha was significantly increased in the skin of TPA-treated WT, especially in the basal and suprabasal layers, but it was restricted focally in basal layer of the skin of TPA-treated Tg EC-SOD.	Tetradecanoylphorbol Acetate	194-197	superoxide dismutase 3, extracellular	Mus musculus	209-215
8745576-1	1995	Cardiomyocytes isolated from neonatal rats were treated with phorbol-12-myristate-13-acetate (PMA) ranging from 10(-11) to 10(-7) mol/L for 20 min, causing cytosol protein kinase A (PKA) activity to decrease while particulate PKA activity increase in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	61-92	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	182-185
8745576-1	1995	Cardiomyocytes isolated from neonatal rats were treated with phorbol-12-myristate-13-acetate (PMA) ranging from 10(-11) to 10(-7) mol/L for 20 min, causing cytosol protein kinase A (PKA) activity to decrease while particulate PKA activity increase in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	61-92	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	226-229
8745576-2	1995	The change of PKA activity induced by PMA was abolished completely by pretreatment of polymyxin B or depletion of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	38-41	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	14-17
7620342-1	1995	Sequence analysis of the promoter region of the murine tyrosinase gene identified various consensus motifs including AP2 sites, cAMP and TPA response elements (CREs/TREs) and retinoic acid response element (RARE) half-sites.	Tetradecanoylphorbol Acetate	137-140	tyrosinase	Mus musculus	55-65
7727044-4	1995	Whereas TPA, okadaic acid, and thapsigarin elevated TGF alpha mRNA levels over similar time courses (peak at 4-8 h), chrysarobin elevated TGF alpha mRNA levels with a markedly delayed time course (peak at 24-48 h).	Tetradecanoylphorbol Acetate	8-11	transforming growth factor alpha	Mus musculus	52-61
16890203-6	2006	The number of infiltrating inflammatory cells and the IL-1beta expressing cells was obviously reduced in TPA-treated Tg EC-SOD in comparison with TPA-treated WT.	Tetradecanoylphorbol Acetate	105-108	superoxide dismutase 3, extracellular	Mus musculus	120-126
7594530-8	1995	To determine whether TAPI would prevent shedding under more physiologic conditions, we demonstrated that TAPI was able to prevent unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes.	Tetradecanoylphorbol Acetate	147-150	TNF receptor superfamily member 1A	Homo sapiens	206-210
16890203-6	2006	The number of infiltrating inflammatory cells and the IL-1beta expressing cells was obviously reduced in TPA-treated Tg EC-SOD in comparison with TPA-treated WT.	Tetradecanoylphorbol Acetate	146-149	superoxide dismutase 3, extracellular	Mus musculus	120-126
16890203-7	2006	The result suggests that EC-SOD might play an important role in the suppression of TPA-induced cutaneous inflammation and epidermal hyperplasia by regulating the expression of IL-1alpha and IL-1beta, although the mechanisms remain to be elucidated.	Tetradecanoylphorbol Acetate	83-86	superoxide dismutase 3, extracellular	Mus musculus	25-31
16890203-7	2006	The result suggests that EC-SOD might play an important role in the suppression of TPA-induced cutaneous inflammation and epidermal hyperplasia by regulating the expression of IL-1alpha and IL-1beta, although the mechanisms remain to be elucidated.	Tetradecanoylphorbol Acetate	83-86	interleukin 1 alpha	Mus musculus	176-185
8587246-7	1995	Furthermore, PMA induced an increase in MCP-1 mRNA levels, whereas dibutyryl cyclic AMP and forskolin had minimal effects.	Tetradecanoylphorbol Acetate	13-16	C-C motif chemokine ligand 2	Homo sapiens	40-45
16478662-2	2006	It has also been documented for the receptor-like protein tyrosine phosphatase PTP-LAR, induced by treating cells with the tumor promoter TPA or the calcium ionophor A23187.	Tetradecanoylphorbol Acetate	138-141	low antibody response	Mus musculus	83-86
8848001-2	1995	Acute pretreatment for 2 min with 100 nM 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C (PKC), abolished the intracellular calcium response induced by 100 nM 5-HT but did not reduce 5-HT1A receptor-mediated inhibition of cAMP.	Tetradecanoylphorbol Acetate	79-82	5-hydroxytryptamine receptor 1A	Homo sapiens	212-227
7592969-9	1995	The phosphorylation of annexin 2 by protein kinase C, MgATP, and 12-O-tetradecanoylphorbol-13-acetate on chromaffin granules induces a fusion of chromaffin granules membranes observed in electron microscopy.	Tetradecanoylphorbol Acetate	65-101	annexin A2	Rattus norvegicus	23-32
7867726-4	1995	Upregulation of RET expression was also found in SK-N-BE cells induced to differentiate by 12-O-tetradecanoylphorbol-13-acetate, glial cell-conditioned medium, alpha or gamma interferon, and in SH-SY-5Y cells exposed to nerve growth factor.	Tetradecanoylphorbol Acetate	91-127	ret proto-oncogene	Homo sapiens	16-19
7860643-11	1995	The role of protein kinase C (PKC) in the EGF-stimulated ERK signaling pathway was further examined by inhibition of PKC with the staurosporine analog, CGP41251, and by down-regulation of PKC via chronic treatment with PMA.	Tetradecanoylphorbol Acetate	219-222	epidermal growth factor	Homo sapiens	42-45
7853525-8	1995	Normally, stimulation of T-cells by IL-2 or phorbol 12-myristate 13-acetate provokes both augmentation of p56lck activity and corresponding posttranslational modification of p56lck.	Tetradecanoylphorbol Acetate	44-75	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-112
7853525-8	1995	Normally, stimulation of T-cells by IL-2 or phorbol 12-myristate 13-acetate provokes both augmentation of p56lck activity and corresponding posttranslational modification of p56lck.	Tetradecanoylphorbol Acetate	44-75	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	174-180
7583591-3	1995	Ten-minute incubation with either phorbol 12-myristate 13-acetate (PMA), thrombin, or L-NAME significantly increased P-selectin expression on platelets (as assessed by flow-cytometric analysis) and PKC activity of platelet membranes.	Tetradecanoylphorbol Acetate	34-65	selectin P	Homo sapiens	117-127
16478662-5	2006	In contrast to TPA-induced shedding of PTP-LAR, EGFR-mediated cleavage did not require PKC-activity.	Tetradecanoylphorbol Acetate	15-18	low antibody response	Mus musculus	43-46
7583591-3	1995	Ten-minute incubation with either phorbol 12-myristate 13-acetate (PMA), thrombin, or L-NAME significantly increased P-selectin expression on platelets (as assessed by flow-cytometric analysis) and PKC activity of platelet membranes.	Tetradecanoylphorbol Acetate	67-70	selectin P	Homo sapiens	117-127
16846837-8	2006	These results suggest that Tau-Cl inhibits PMA-elicited O(2)(-) production in PLB-985 granulocytes by inhibiting phosphorylation of p47(phox) and translocation of p47(phox) and p67(phox), eventually blocking the assembly of NADPH oxidase complex.	Tetradecanoylphorbol Acetate	43-46	pleckstrin	Homo sapiens	132-141
7583591-4	1995	Increased P-selectin expression induced by either PMA, thrombin, or L-NAME was significantly attenuated by the selective PKC inhibitor UCN-01 (7-hydroxystaurosporine).	Tetradecanoylphorbol Acetate	50-53	selectin P	Homo sapiens	10-20
7586191-5	1995	Skin hyperplasia induced by one topical application of TPA was accompanied by hyperexpression of both Cx26 and Cx43.	Tetradecanoylphorbol Acetate	55-58	gap junction protein, beta 2	Mus musculus	102-106
7829270-4	1995	Both DNFB and TPA caused marked induction of ODC, c-fos and c-jun mRNA.	Tetradecanoylphorbol Acetate	14-17	FBJ osteosarcoma oncogene	Mus musculus	50-55
16846837-8	2006	These results suggest that Tau-Cl inhibits PMA-elicited O(2)(-) production in PLB-985 granulocytes by inhibiting phosphorylation of p47(phox) and translocation of p47(phox) and p67(phox), eventually blocking the assembly of NADPH oxidase complex.	Tetradecanoylphorbol Acetate	43-46	pleckstrin	Homo sapiens	163-172
7835292-11	1995	EGF, on the other hand, only enhanced cell proliferation at a late stage (coincident with the TPA-mitogenic effect).	Tetradecanoylphorbol Acetate	94-97	epidermal growth factor	Homo sapiens	0-3
7586191-6	1995	In addition, TPA significantly inhibited the expression of Cx31.1.	Tetradecanoylphorbol Acetate	13-16	gap junction protein, beta 3	Mus musculus	59-63
7853198-2	1995	Combined treatment of human umbilical endothelial cells with TNF-alpha and the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed the TNF-alpha-induced production of IL-1 alpha.	Tetradecanoylphorbol Acetate	112-148	interleukin 1 alpha	Homo sapiens	202-212
7853198-2	1995	Combined treatment of human umbilical endothelial cells with TNF-alpha and the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed the TNF-alpha-induced production of IL-1 alpha.	Tetradecanoylphorbol Acetate	150-153	interleukin 1 alpha	Homo sapiens	202-212
7853198-4	1995	Pretreatment with TPA for 15 min was enough to suppress the TNF-alpha-induced IL-1 alpha production.	Tetradecanoylphorbol Acetate	18-21	interleukin 1 alpha	Homo sapiens	78-88
7554401-5	1995	Importantly, the levels of mRNA encoding c-myc, IL-2R alpha, IL-2 and IFN-gamma were markedly decreased in patient lymphocytes stimulated with PMA+ionomycin as compared to control lymphocytes.	Tetradecanoylphorbol Acetate	143-146	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	41-46
16846837-8	2006	These results suggest that Tau-Cl inhibits PMA-elicited O(2)(-) production in PLB-985 granulocytes by inhibiting phosphorylation of p47(phox) and translocation of p47(phox) and p67(phox), eventually blocking the assembly of NADPH oxidase complex.	Tetradecanoylphorbol Acetate	43-46	pleckstrin	Homo sapiens	136-140
16846840-0	2006	HIV-1 gp120 up-regulation of the mu opioid receptor in TPA-differentiated HL-60 cells.	Tetradecanoylphorbol Acetate	55-58	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	6-11
8589919-4	1995	To investigate whether HSA also is involved in T-cell activation by KC, normal murine KC or the spontaneously transformed KC cell-line PAM 212 were treated with PDB or PMA to induce HSA-expression.	Tetradecanoylphorbol Acetate	168-171	CD24a antigen	Mus musculus	182-185
16846840-0	2006	HIV-1 gp120 up-regulation of the mu opioid receptor in TPA-differentiated HL-60 cells.	Tetradecanoylphorbol Acetate	55-58	opioid receptor mu 1	Homo sapiens	33-51
7853198-6	1995	Stimulation of cell-associated IL-1 alpha production by IL-1 beta or lipopolysaccharide was also inhibited by pretreatment with the PKC activator TPA, aplysiatoxin or teleocidin.	Tetradecanoylphorbol Acetate	146-149	interleukin 1 alpha	Homo sapiens	31-41
16846840-5	2006	In this study, we examined the effects of HIV-1 gp120 on MOR expression in HL-60 human promyelocytic leukemia cells differentiated into macrophage-like cells by TPA.	Tetradecanoylphorbol Acetate	161-164	opioid receptor mu 1	Homo sapiens	57-60
7853198-8	1995	The present work indicates that the production of cell-associated IL-1 alpha stimulated by TNF-alpha, IL-1 beta or lipopolysaccharide is inhibited by treatment with TPA, aplysiatoxin or teleocidin.	Tetradecanoylphorbol Acetate	165-168	interleukin 1 alpha	Homo sapiens	66-76
7559807-6	1995	Phosphorylation may not act directly on latent transcription factors, since bromophenacyl bromide, an inhibitor for the release of arachidonic acid from phorbol-12 myristate 13-acetate (PMA)-stimulated HL 60 cells, markedly depressed the induced mRNAs for IL-8, TNF-alpha, and IL-1 alpha and -beta.	Tetradecanoylphorbol Acetate	186-189	interleukin 1 alpha	Homo sapiens	277-287
16846840-6	2006	Using real time RT-PCR, we found that exposure to gp120 up-regulated MOR expression in TPA-differentiated HL-60 cells at the transcriptional level.	Tetradecanoylphorbol Acetate	87-90	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	50-55
7500645-2	1995	Treatment of U-937 cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA) which is associated with the induction of a monocytic differentiation program and growth arrest, revealed an initial up-regulation of c-myc, c-max, and mxi1 mRNAs after 1-6 h. Thereafter expression of these genes significantly declined to barely detectable levels when the cells ceased to grow after 12-24 h of TPA treatment.	Tetradecanoylphorbol Acetate	30-67	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	208-213
16846840-6	2006	Using real time RT-PCR, we found that exposure to gp120 up-regulated MOR expression in TPA-differentiated HL-60 cells at the transcriptional level.	Tetradecanoylphorbol Acetate	87-90	opioid receptor mu 1	Homo sapiens	69-72
7500645-2	1995	Treatment of U-937 cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA) which is associated with the induction of a monocytic differentiation program and growth arrest, revealed an initial up-regulation of c-myc, c-max, and mxi1 mRNAs after 1-6 h. Thereafter expression of these genes significantly declined to barely detectable levels when the cells ceased to grow after 12-24 h of TPA treatment.	Tetradecanoylphorbol Acetate	69-72	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	208-213
8672911-4	1995	RESULTS: In all three collectives, PAI-1 plasma concentrations were significantly higher (p &lt; 0,05) than in normal pregnancies, in patients with HELLP-syndrome, tPA and TIMP-1 plasma levels were also elevated.	Tetradecanoylphorbol Acetate	164-167	serpin family E member 1	Homo sapiens	35-40
16846840-8	2006	Exposure to gp120 also stimulated the release of TNF-alpha from TPA-differentiated HL-60 cells.	Tetradecanoylphorbol Acetate	64-67	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	12-17
16846840-10	2006	Our data suggest that one of the mechanisms by which HIV-1 gp120 up-regulates the MOR in TPA-differentiated HL-60 cells is through autocrine/paracrine actions of TNF-alpha via the TNFR-II receptor.	Tetradecanoylphorbol Acetate	89-92	opioid receptor mu 1	Homo sapiens	82-85
7557381-4	1995	A second tyrosine kinase activity is induced in response to both calcium and TPA, and has been identified as fyn, a nonreceptor tyrosine kinase of the src family.	Tetradecanoylphorbol Acetate	77-80	Rous sarcoma oncogene	Mus musculus	151-154
7557381-6	1995	Cortactin, a p80-85 substrate of src- and fyn-related kinases that localizes with actin at cell adhesion sites, is increasingly tyrosine phosphorylated in calcium- and TPA-induced differentiation, with a time course which parallels that of fyn activation.	Tetradecanoylphorbol Acetate	168-171	cortactin	Mus musculus	0-9
16804093-5	2006	These results were paralleled in human platelets, in which PMA reduced subsequent ADP-induced P2Y1 and P2Y12 receptor signaling.	Tetradecanoylphorbol Acetate	59-62	purinergic receptor P2Y1	Homo sapiens	94-98
7557381-6	1995	Cortactin, a p80-85 substrate of src- and fyn-related kinases that localizes with actin at cell adhesion sites, is increasingly tyrosine phosphorylated in calcium- and TPA-induced differentiation, with a time course which parallels that of fyn activation.	Tetradecanoylphorbol Acetate	168-171	Rous sarcoma oncogene	Mus musculus	33-36
7665919-0	1995	Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor-promoter-caused induction of epidermal interleukin-1 alpha mRNA and protein expression in SENCAR mice by green tea polyphenols.	Tetradecanoylphorbol Acetate	14-50	interleukin 1 alpha	Mus musculus	111-130
21043585-4	1995	GM-CSF dependent proliferation of MB-02, as measured by (3)H-thymidine uptake, was greater than 95% inhibited by TPA (16 nM), but was not affected by the inactive stereoisomer, 4-alpha-phorbol-12,13-didecanoate (4-alphaPDD).	Tetradecanoylphorbol Acetate	113-116	colony stimulating factor 2	Homo sapiens	0-6
21043585-6	1995	C-myc expression was turned off by TPA (16 nM) stimulation of cells within 2-4 h. This TPA-mediated effect likely occurred at the transcriptional level since the half life of c-myc mRN A induced by GM-CSF was less than 30 min.	Tetradecanoylphorbol Acetate	35-38	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
16613839-1	2006	Previous studies in our laboratory demonstrated that 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA) treatment induced apoptosis and mitochondrial translocation of the tumor suppressor p53 in a mouse skin carcinogenesis model, suggesting that oncogenic versus cell death signaling involve a common mediator.	Tetradecanoylphorbol Acetate	84-120	transformation related protein 53, pseudogene	Mus musculus	216-219
7806548-6	1994	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) could in itself induce c-fos expression, but pretreatment with TPA did not abolish the ability of norepinephrine to induce c-fos expression, indicating that TPA-sensitive protein kinase C was not a primary mediator in this pathway.	Tetradecanoylphorbol Acetate	18-54	FBJ osteosarcoma oncogene	Mus musculus	84-89
7806548-6	1994	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) could in itself induce c-fos expression, but pretreatment with TPA did not abolish the ability of norepinephrine to induce c-fos expression, indicating that TPA-sensitive protein kinase C was not a primary mediator in this pathway.	Tetradecanoylphorbol Acetate	56-59	FBJ osteosarcoma oncogene	Mus musculus	84-89
7806548-6	1994	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) could in itself induce c-fos expression, but pretreatment with TPA did not abolish the ability of norepinephrine to induce c-fos expression, indicating that TPA-sensitive protein kinase C was not a primary mediator in this pathway.	Tetradecanoylphorbol Acetate	56-59	FBJ osteosarcoma oncogene	Mus musculus	184-189
7665919-1	1995	Recent studies have shown that topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to murine skin results in increased expression of the highly inflammatory cytokine interleukin (IL)-1 alpha in the epidermis.	Tetradecanoylphorbol Acetate	73-109	interleukin 1 alpha	Mus musculus	199-223
7665919-1	1995	Recent studies have shown that topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to murine skin results in increased expression of the highly inflammatory cytokine interleukin (IL)-1 alpha in the epidermis.	Tetradecanoylphorbol Acetate	111-114	interleukin 1 alpha	Mus musculus	199-223
7665919-2	1995	This has led to the suggestion that IL-1 alpha directly or indirectly mediates the inflammatory and hyperplastic responses elicited by TPA and possibly by other skin tumor promoters.	Tetradecanoylphorbol Acetate	135-138	interleukin 1 alpha	Mus musculus	36-46
7665919-5	1995	Northern blot analysis indicated that topical application of TPA, anthralin, mezerein, or benzoyl peroxide to SENCAR mice resulted in an increased expression of epidermal IL-1 alpha mRNA.	Tetradecanoylphorbol Acetate	61-64	interleukin 1 alpha	Mus musculus	171-181
7665919-6	1995	Pretreatment of the skin with GTP or individual epicatechin derivatives (ECDs) present therein, 30 min before that of TPA, resulted in a significant inhibition of enhanced expression of epidermal IL-1 alpha mRNA caused by skin application of TPA.	Tetradecanoylphorbol Acetate	118-121	interleukin 1 alpha	Mus musculus	196-206
7665919-6	1995	Pretreatment of the skin with GTP or individual epicatechin derivatives (ECDs) present therein, 30 min before that of TPA, resulted in a significant inhibition of enhanced expression of epidermal IL-1 alpha mRNA caused by skin application of TPA.	Tetradecanoylphorbol Acetate	242-245	interleukin 1 alpha	Mus musculus	196-206
16613839-1	2006	Previous studies in our laboratory demonstrated that 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA) treatment induced apoptosis and mitochondrial translocation of the tumor suppressor p53 in a mouse skin carcinogenesis model, suggesting that oncogenic versus cell death signaling involve a common mediator.	Tetradecanoylphorbol Acetate	127-130	transformation related protein 53, pseudogene	Mus musculus	216-219
7478915-4	1995	However, PMA or phorbol 12,13-dibutyrate (PdBu), but not the inactive 4alpha-phorbol 12,13-didecanoate (4alpha-PDD), reduced the frequency of GnRH-induced [Ca2+]i oscillation and augmented the IK(Ca) induced by any given level of [Ca2+]i.	Tetradecanoylphorbol Acetate	9-12	gonadotropin releasing hormone 1	Rattus norvegicus	142-146
16613839-3	2006	A malignant skin keratinocyte cell line (308), which carries a H-ras mutation at codon 61, showed elevated p53 levels, increased caspase 3 activity and enhanced apoptosis after TPA treatment.	Tetradecanoylphorbol Acetate	177-180	transformation related protein 53, pseudogene	Mus musculus	107-110
16613839-5	2006	Inhibition of NADPH-oxidase (NOX) by diphenyleneiodonium suppressed p53 activation and apoptosis in 308 cells, linking Ras mutation to NOX-induced p53 activation, which was further supported by the finding that siRNA to Rac1 inhibited p53 activation after TPA treatment.	Tetradecanoylphorbol Acetate	256-259	transformation related protein 53, pseudogene	Mus musculus	147-150
7500380-1	1995	SH-SY5Y cells differentiate into neuronal-like cells and express marker proteins like growth-associated protein (GAP-43) and neuropeptide tyrosine when treated with a low concentration (16 nM) of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in the presence of growth factors or serum.	Tetradecanoylphorbol Acetate	214-250	growth associated protein 43	Homo sapiens	113-119
16613839-5	2006	Inhibition of NADPH-oxidase (NOX) by diphenyleneiodonium suppressed p53 activation and apoptosis in 308 cells, linking Ras mutation to NOX-induced p53 activation, which was further supported by the finding that siRNA to Rac1 inhibited p53 activation after TPA treatment.	Tetradecanoylphorbol Acetate	256-259	transformation related protein 53, pseudogene	Mus musculus	147-150
16613839-6	2006	Application of DPI to DMBA-initiated skin tissue significantly blocked TPA-mediated increased p53 levels and reduced apoptosis in skin epidermal tissues.	Tetradecanoylphorbol Acetate	71-74	transformation related protein 53, pseudogene	Mus musculus	94-97
8547224-0	1995	Serum response element and flanking sequences mediate the synergistic transcriptional activation of c-fos by 12-O-tetradecanoylphorbol-13-acetate and cholera toxin in AKR-2B cells.	Tetradecanoylphorbol Acetate	109-145	FBJ osteosarcoma oncogene	Mus musculus	100-105
16843450-3	2006	METHODS AND RESULTS: Acute exposure of a mouse macrophage cell line (RAW 264.7) to both PMA and oxLDL provoked ROS generation that was blocked by the PKCalpha/beta1 inhibitor Go 6967.	Tetradecanoylphorbol Acetate	88-91	hemoglobin, beta adult major chain	Mus musculus	159-164
7628389-6	1995	Treatment of normal mouse Leydig cells in primary culture with 50 microM 8-bromo-cAMP (cAMP) plus 1 ng/ml TNF alpha or 10 nM PMA caused a similar (approximately 90%) decrease in testosterone accumulation and cAMP-stimulated P450c17 messenger RNA levels compared to those after treatment with cAMP alone.	Tetradecanoylphorbol Acetate	125-128	cytochrome P450, family 17, subfamily a, polypeptide 1	Mus musculus	224-231
7675040-4	1995	We found that IL-1 + TPA-treated cells contain significantly higher Jun B protein levels than cells treated with TPA alone.	Tetradecanoylphorbol Acetate	21-24	jun B proto-oncogene	Mus musculus	68-73
7675040-9	1995	Thus, the stimulation of AP-1-mediated gene expression by IL-1 in EL4 cells is due to the promotion of Jun B protein accumulation that, in turn, facilitates Jun B heterodimerization with TPA-induced Fra-1 protein, thereby forming an active AP-1 complex.	Tetradecanoylphorbol Acetate	187-190	jun B proto-oncogene	Mus musculus	103-108
16574739-6	2006	In vivo, IRS-1 is also phosphorylated on Ser24 after phorbol 12-myristate 13-acetate treatment of cells, and isoform-selective inhibitor studies suggest the involvement of PKCalpha.	Tetradecanoylphorbol Acetate	53-84	insulin receptor substrate 1	Homo sapiens	9-14
7675040-9	1995	Thus, the stimulation of AP-1-mediated gene expression by IL-1 in EL4 cells is due to the promotion of Jun B protein accumulation that, in turn, facilitates Jun B heterodimerization with TPA-induced Fra-1 protein, thereby forming an active AP-1 complex.	Tetradecanoylphorbol Acetate	187-190	fos-like antigen 1	Mus musculus	199-204
7615560-2	1995	We have previously reported that the promoter region of the mouse interleukin-5 (IL-5) gene, extending from a nucleotide position about -1,200 to +33 relative to the transcription initiation site, can mediate transcriptional stimulation by phorbol 12-myristate 13-acetate and dibutyryl cAMP (Bt2cAMP) in mouse thymoma EL-4 cells.	Tetradecanoylphorbol Acetate	240-271	interleukin 5	Mus musculus	66-79
7527667-6	1994	Phorbol myristate acetate (PMA) induced a twofold greater increase in IL-11 mRNA expression in neonatal fibroblasts (NFb) compared with adult fibroblasts (AFb), and a 3.6-fold greater increase in HUVEC than human adult aorta endothelial cells (HAEC) by Northern blot analysis.	Tetradecanoylphorbol Acetate	0-25	interleukin 11	Homo sapiens	70-75
7527667-6	1994	Phorbol myristate acetate (PMA) induced a twofold greater increase in IL-11 mRNA expression in neonatal fibroblasts (NFb) compared with adult fibroblasts (AFb), and a 3.6-fold greater increase in HUVEC than human adult aorta endothelial cells (HAEC) by Northern blot analysis.	Tetradecanoylphorbol Acetate	27-30	interleukin 11	Homo sapiens	70-75
7527667-7	1994	PMA also induced a threefold greater increase in IL-11 protein production in NFb than AFb.	Tetradecanoylphorbol Acetate	0-3	interleukin 11	Homo sapiens	49-54
7615560-2	1995	We have previously reported that the promoter region of the mouse interleukin-5 (IL-5) gene, extending from a nucleotide position about -1,200 to +33 relative to the transcription initiation site, can mediate transcriptional stimulation by phorbol 12-myristate 13-acetate and dibutyryl cAMP (Bt2cAMP) in mouse thymoma EL-4 cells.	Tetradecanoylphorbol Acetate	240-271	interleukin 5	Mus musculus	81-85
7547506-2	1995	Prolonged treatment of RD cells with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induces growth arrest and myogenic differentiation as shown by the accumulation of alpha-actin and myosin light and heavy chains, without affecting the expression of MyoD and myogenin.	Tetradecanoylphorbol Acetate	74-110	myosin heavy chain 14	Homo sapiens	216-222
7637391-0	1995	The protein kinase C inhibitor H7 blocks phosphorylation of stathmin during TPA-induced growth inhibition of human pre-B leukemia REH6 cells.	Tetradecanoylphorbol Acetate	76-79	stathmin 1	Homo sapiens	60-68
16934082-4	2006	RESULTS: In combination with conventional binding analysis it was found that binding to phorbol 12-myristate 13-acetate-matured THP-1 cells is primarily regulated by PLT P-selectin expression and phagocytosis by combined phosphatidylserine (PS) exposure and glycoprotein (GP) Ibalpha clustering.	Tetradecanoylphorbol Acetate	88-119	selectin P	Homo sapiens	170-180
7791759-7	1995	Upon stimulation of RelA-overexpressing thymocytes with phorbol 12-myristate 13-acetate and lectin (phytohemaglutinin), different kappa B-binding complexes, including RelA homodimers, were partially released from I kappa B alpha.	Tetradecanoylphorbol Acetate	56-87	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	20-24
7791759-7	1995	Upon stimulation of RelA-overexpressing thymocytes with phorbol 12-myristate 13-acetate and lectin (phytohemaglutinin), different kappa B-binding complexes, including RelA homodimers, were partially released from I kappa B alpha.	Tetradecanoylphorbol Acetate	56-87	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	167-171
7611439-3	1995	We isolated uPAR from MS-1 cells by metabolic labeling and showed that it could be induced by phorbol myristate acetate (PMA), lipopolysaccharide (LPS), a transforming growth factor-beta (TGF-beta) or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	94-119	plasminogen activator, urokinase receptor	Homo sapiens	12-16
7611439-3	1995	We isolated uPAR from MS-1 cells by metabolic labeling and showed that it could be induced by phorbol myristate acetate (PMA), lipopolysaccharide (LPS), a transforming growth factor-beta (TGF-beta) or tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	121-124	plasminogen activator, urokinase receptor	Homo sapiens	12-16
7558244-9	1995	Furthermore, chronic exposure to TPA or treatment with herbimycin A results in the enhancement of the hypoxia-mediated increase in VEGF mRNA levels.	Tetradecanoylphorbol Acetate	33-36	vascular endothelial growth factor A	Rattus norvegicus	131-135
7751619-8	1995	The induction of ATF-1 required the costimulation of normal T lymphocytes with TPA and A23187.	Tetradecanoylphorbol Acetate	79-82	activating transcription factor 1	Homo sapiens	17-22
7760005-12	1995	FMLP-induced release of the IL-1 decoy RII was unaffected by protein synthesis inhibitors, was blocked by certain protease inhibitors, and was mimicked by agents (the Ca++ ionophore A23187 and phorbol myristate acetate) that recapitulate elements in the signal transduction pathway of chemoattractant receptors.	Tetradecanoylphorbol Acetate	193-218	interleukin 1 alpha	Homo sapiens	28-32
7790925-10	1995	Regulation of the protein kinase C pathway with phorbol myristate acetate (PMA) stimulated SCG neuronal NPY secretion to a lesser degree than activation of protein kinase A, but did not alter cellular NPY levels.	Tetradecanoylphorbol Acetate	48-73	neuropeptide Y	Homo sapiens	104-107
7790925-10	1995	Regulation of the protein kinase C pathway with phorbol myristate acetate (PMA) stimulated SCG neuronal NPY secretion to a lesser degree than activation of protein kinase A, but did not alter cellular NPY levels.	Tetradecanoylphorbol Acetate	75-78	neuropeptide Y	Homo sapiens	104-107
7745729-4	1995	Both TPA and antiimmunoglobulin antibody are known to activate expression of the cellular transcription factor Zif268 in B cells.	Tetradecanoylphorbol Acetate	5-8	early growth response 1	Homo sapiens	111-117
7745729-9	1995	TPA treatment of B cells induces the expression of Zif268 protein, which binds to Rp.	Tetradecanoylphorbol Acetate	0-3	early growth response 1	Homo sapiens	51-57
7745729-10	1995	Furthermore, TPA activation of Rp requires the upstream Zif268 site.	Tetradecanoylphorbol Acetate	13-16	early growth response 1	Homo sapiens	56-62
7760824-4	1995	Intriguingly, TPA-mediated repression of the cdc2 promoter was independent of the transcription factor E2F, distinguishing this pathway from mechanisms responsible for repression of cdc2 transcription in response to serum starvation.	Tetradecanoylphorbol Acetate	14-17	cyclin dependent kinase 1	Homo sapiens	45-49
7760824-4	1995	Intriguingly, TPA-mediated repression of the cdc2 promoter was independent of the transcription factor E2F, distinguishing this pathway from mechanisms responsible for repression of cdc2 transcription in response to serum starvation.	Tetradecanoylphorbol Acetate	14-17	cyclin dependent kinase 1	Homo sapiens	182-186
7760824-7	1995	Analysis of THP1 nuclear proteins revealed a 55-kDa protein that was induced by TPA and interacted with the cdc2 promoter in an R-box-dependent manner.	Tetradecanoylphorbol Acetate	80-83	cyclin dependent kinase 1	Homo sapiens	108-112
7998975-4	1994	Epidermal growth factor, platelet-derived growth factor, serum and phorbol myristate acetate all increase the half-life of cPLA2 mRNA transcripts, indicating a role for post-transcriptional modulation of gene expression.	Tetradecanoylphorbol Acetate	67-92	phospholipase A2 group IVA	Rattus norvegicus	123-128
7988452-7	1994	Furthermore, phorbol 12-myristate 13-acetate potentiated the stimulatory effect of EGF.	Tetradecanoylphorbol Acetate	13-44	epidermal growth factor	Homo sapiens	83-86
7961944-3	1994	These results indicate that in clone 112 cells the growth suppressor activity of the wild-type p53 species is inactivated at 37 degrees C. We show that clone 112 cells grown at 37 degrees C elicits specific growth inhibition response to stimulation by the tumor promoter phorbol ester, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	286-317	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	95-98
7961944-3	1994	These results indicate that in clone 112 cells the growth suppressor activity of the wild-type p53 species is inactivated at 37 degrees C. We show that clone 112 cells grown at 37 degrees C elicits specific growth inhibition response to stimulation by the tumor promoter phorbol ester, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	319-322	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	95-98
7961944-4	1994	At 37 degrees C, PMA induced nuclear accumulation of the p53 protein, a behavior that is also observed in growth-arrested cells at 32 degrees C. Furthermore, when cells are growth arrested at 32 degrees C, PMA prevented the cells from re-entering the cell cycle when they are shifted back to 37 degrees C. All these observations suggest that PMA can cooperate with the wild-type p53 in cell growth arrest.	Tetradecanoylphorbol Acetate	17-20	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	57-60
7961944-4	1994	At 37 degrees C, PMA induced nuclear accumulation of the p53 protein, a behavior that is also observed in growth-arrested cells at 32 degrees C. Furthermore, when cells are growth arrested at 32 degrees C, PMA prevented the cells from re-entering the cell cycle when they are shifted back to 37 degrees C. All these observations suggest that PMA can cooperate with the wild-type p53 in cell growth arrest.	Tetradecanoylphorbol Acetate	17-20	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	379-382
7982208-2	1994	Xenopus c-jun mRNA is induced in quiescent Xenopus A6 kidney cells by 12-O-tetradecanoylphorbol-13-acetate, PDGF and cycloheximide.	Tetradecanoylphorbol Acetate	70-106	jun proto-oncogene L homeolog	Xenopus laevis	8-13
7926038-1	1994	The modulation of urokinase plasminogen activator receptor (uPAR) gene expression by tumor necrosis factor alpha (TNF alpha), phorbol ester (PMA) and amiloride was studied in three colon cancer cell lines.	Tetradecanoylphorbol Acetate	141-144	plasminogen activator, urokinase receptor	Homo sapiens	18-58
7926038-1	1994	The modulation of urokinase plasminogen activator receptor (uPAR) gene expression by tumor necrosis factor alpha (TNF alpha), phorbol ester (PMA) and amiloride was studied in three colon cancer cell lines.	Tetradecanoylphorbol Acetate	141-144	plasminogen activator, urokinase receptor	Homo sapiens	60-64
7869421-3	1994	The exposure to MC and/or PMA caused a rapid increase in c-fos mRNA content, which was immediately followed by an increase in c-jun mRNA, prior to NGF mRNA elevation.	Tetradecanoylphorbol Acetate	26-29	FBJ osteosarcoma oncogene	Mus musculus	57-62
7869421-4	1994	The expression of c-fos mRNA was transiently enhanced in all cases of the treatment with MC and/or PMA.	Tetradecanoylphorbol Acetate	99-102	FBJ osteosarcoma oncogene	Mus musculus	18-23
7945348-2	1994	Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after treatment with recombinant interferon-gamma (rIFN-gamma) resulted in the increased production of NO in the medium.	Tetradecanoylphorbol Acetate	58-89	interferon gamma	Rattus norvegicus	147-157
7945348-2	1994	Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after treatment with recombinant interferon-gamma (rIFN-gamma) resulted in the increased production of NO in the medium.	Tetradecanoylphorbol Acetate	91-94	interferon gamma	Rattus norvegicus	147-157
7925128-7	1994	The addition of phospholipase-A2, phorbol myristate acetate (protein kinase-C activator), or arachidonic acid stimulated SOR production in plasma membrane samples from ovaries of control rats, and phorbol myristate acetate and arachidonic acid inhibited LH-stimulated progesterone secretion in dispersed rat luteal cells.	Tetradecanoylphorbol Acetate	197-222	phospholipase A2 group IB	Rattus norvegicus	16-32
7523156-8	1994	EGF and TNF-alpha could enhance c-fos gene expression when protein kinase C was down-regulated by phorbol ester myristate (PMA).	Tetradecanoylphorbol Acetate	123-126	epidermal growth factor	Homo sapiens	0-3
7815740-2	1994	When growth-arrested MC were stimulated with 100 nM phorbol myristate acetate (PMA) for 24 hours, an increased expression of smooth muscle alpha-actin and vimentin was detected by immunocytochemistry.	Tetradecanoylphorbol Acetate	52-77	actin alpha 2, smooth muscle	Rattus norvegicus	125-150
7815740-2	1994	When growth-arrested MC were stimulated with 100 nM phorbol myristate acetate (PMA) for 24 hours, an increased expression of smooth muscle alpha-actin and vimentin was detected by immunocytochemistry.	Tetradecanoylphorbol Acetate	79-82	actin alpha 2, smooth muscle	Rattus norvegicus	125-150
7716737-0	1994	12-O-tetradecanoyl-phorbol-13-acetate-induced rat embryo malformations in vitro are associated with an increased relative abundance of embryonic E-cadherin mRNA.	Tetradecanoylphorbol Acetate	0-37	cadherin 1	Rattus norvegicus	145-155
7716737-4	1994	The present study investigated the possibility that the effect of TPA on yolk sac development may be due to the altered expression of E-cadherin.	Tetradecanoylphorbol Acetate	66-69	cadherin 1	Rattus norvegicus	134-144
7716737-10	1994	However, in embryos exposed to dysmorphogenic concentrations of TPA, the relative abundance of E-cadherin mRNA was significantly increased after 24 hr in culture, compared to either controls or embryos exposed to non-dysmorphogenic concentrations of TPA.	Tetradecanoylphorbol Acetate	64-67	cadherin 1	Rattus norvegicus	95-105
7716737-10	1994	However, in embryos exposed to dysmorphogenic concentrations of TPA, the relative abundance of E-cadherin mRNA was significantly increased after 24 hr in culture, compared to either controls or embryos exposed to non-dysmorphogenic concentrations of TPA.	Tetradecanoylphorbol Acetate	250-253	cadherin 1	Rattus norvegicus	95-105
7521695-5	1994	Treatment of K562 cells with the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), administration of interferon alpha (IFN alpha) to normal monocytes, and treatment of U937 cells with TPA and IFN tau significantly induced axl expression, supporting a role for this kinase in the intracellular signaling of myeloid cells through a variety of biochemical pathways.	Tetradecanoylphorbol Acetate	48-84	AXL receptor tyrosine kinase	Homo sapiens	231-234
8082737-6	1994	Moreover, irradiation increased GM-CSF mRNA in cells with prolonged exposure to 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	80-117	colony stimulating factor 2	Homo sapiens	32-38
8082737-6	1994	Moreover, irradiation increased GM-CSF mRNA in cells with prolonged exposure to 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	119-122	colony stimulating factor 2	Homo sapiens	32-38
8082940-7	1994	TPA treatment also resulted in an inhibition of C-type natriuretic peptide-stimulated cGMP production (59 +/- 7% of control); however, this response persisted for as long as 24 hours after addition of the agonist.	Tetradecanoylphorbol Acetate	0-3	natriuretic peptide C	Bos taurus	48-74
8083467-4	1994	In contrast, cAMP almost completely inhibited the PMA-dependent activation of the endogenous IL-2 gene, as well as the transfected IL-2 promoter.	Tetradecanoylphorbol Acetate	50-53	interleukin 2	Mus musculus	93-97
8053680-3	1994	In the present study, treatment of neutrophils with PMA (10(-7) M) for 10 min caused a complete loss of PAF receptors from the cell surface as determined by specific radioligand binding.	Tetradecanoylphorbol Acetate	52-55	PCNA clamp associated factor	Homo sapiens	104-107
8053680-6	1994	This contention is based upon: (i) disruption of PMA-treated neutrophils exposed latent PAF binding sites, while PAF receptors downregulated following A23187 treatment failed to recover upon cell disruption; (ii) PMA-induced PAF receptor downregulation was not observed in cell homogenate preparations, suggesting that cellular integrity which facilitates receptor internalization or redistribution was required; (iii) cytochalasin B, an agent capable of disrupting microfilaments, attenuated PMA-induced PAF receptor downregulation.	Tetradecanoylphorbol Acetate	49-52	PCNA clamp associated factor	Homo sapiens	88-91
8053680-8	1994	Thus, the cellular basis for PMA-induced PAF receptor loss from human neutrophils and mononuclear leukocytes likely involves internalization or cellular redistribution of the PAF receptor.	Tetradecanoylphorbol Acetate	29-32	PCNA clamp associated factor	Homo sapiens	41-44
8053680-8	1994	Thus, the cellular basis for PMA-induced PAF receptor loss from human neutrophils and mononuclear leukocytes likely involves internalization or cellular redistribution of the PAF receptor.	Tetradecanoylphorbol Acetate	29-32	PCNA clamp associated factor	Homo sapiens	175-178
8060360-4	1994	Several cell lines expressed HB-EGF mRNA transcripts, and the transcript level was enhanced by HB-EGF, as well as by 12-O-tetradecanoylphorbol-13-acetate and transforming growth factor-alpha (TGF-alpha).	Tetradecanoylphorbol Acetate	117-153	heparin binding EGF like growth factor	Homo sapiens	29-35
8068015-0	1994	Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells.	Tetradecanoylphorbol Acetate	23-54	solute carrier family 2 member 4	Rattus norvegicus	106-111
8068019-3	1994	Here, we have studied the binding capacity of recombinant annexin V (rANV) to quiescent, phorbol 12-myristate 13-acetate (PMA)- and tumour necrosis factor alpha (TNF-alpha)-stimulated cultured human umbilical-vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	89-120	annexin A5	Homo sapiens	58-67
8068019-3	1994	Here, we have studied the binding capacity of recombinant annexin V (rANV) to quiescent, phorbol 12-myristate 13-acetate (PMA)- and tumour necrosis factor alpha (TNF-alpha)-stimulated cultured human umbilical-vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	122-125	annexin A5	Homo sapiens	58-67
7521138-2	1994	Unlike the response to bradykinin, C5a and tumor necrosis factor-alpha (TNF-alpha) previously reported (15), the PMA-induced increase in [Ca2+]i was predominantly dependent on extracellular calcium.	Tetradecanoylphorbol Acetate	113-116	complement C5	Rattus norvegicus	35-70
7849624-0	1994	Regulation of cell growth and the c-myc proto-oncogene expression by phorbol ester 12-0-tetradecanoyl phorbol-13-acetate (TPA) in the androgen-independent human prostatic JCA-1 cells.	Tetradecanoylphorbol Acetate	122-125	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	34-39
8036018-6	1994	By directly comparing JBSV4 and rat junB mRNA levels, we found that these genes were induced to equivalent levels by serum, TPA, cyclic AMP, platelet-derived growth factor, epidermal growth factor, and basic fibroblastic growth factor.	Tetradecanoylphorbol Acetate	124-127	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	36-40
8036020-4	1994	Interestingly, the effects of TPA are mimicked by the protein kinase inhibitor, staurosporine, which induces the expression of TPA target genes such as the neuronal differentiation-associated gene NPY in SH-SY5Y cells.	Tetradecanoylphorbol Acetate	30-33	neuropeptide Y	Homo sapiens	197-200
8036020-4	1994	Interestingly, the effects of TPA are mimicked by the protein kinase inhibitor, staurosporine, which induces the expression of TPA target genes such as the neuronal differentiation-associated gene NPY in SH-SY5Y cells.	Tetradecanoylphorbol Acetate	127-130	neuropeptide Y	Homo sapiens	197-200
8036020-8	1994	Both staurosporine and TPA enhanced and modulated the binding of these DNA-protein complexes concomitant with the NPY mRNA expression.	Tetradecanoylphorbol Acetate	23-26	neuropeptide Y	Homo sapiens	114-117
8036020-11	1994	These protein complexes appear to contribute to the cell specific expression of the NPY gene and seem to be required during differentiation of SH-SY5Y human neuroblastoma cells further along the sympathetic neuronal lineage induced by either TPA or staurosporine.	Tetradecanoylphorbol Acetate	242-245	neuropeptide Y	Homo sapiens	84-87
8025274-7	1994	Untreated K562 leukemia cells did not contain PAEP, whereas treatment of the cells with tetradecanoylphorbol acetate (TPA) induced strong expression of PAEP mRNA and synthesis of the intact protein that was found both in the cytoplasm of the differentiating cells and in the supernatant of TPA-treated cultures.	Tetradecanoylphorbol Acetate	88-116	progestagen associated endometrial protein	Homo sapiens	152-156
8025274-7	1994	Untreated K562 leukemia cells did not contain PAEP, whereas treatment of the cells with tetradecanoylphorbol acetate (TPA) induced strong expression of PAEP mRNA and synthesis of the intact protein that was found both in the cytoplasm of the differentiating cells and in the supernatant of TPA-treated cultures.	Tetradecanoylphorbol Acetate	118-121	progestagen associated endometrial protein	Homo sapiens	152-156
8025274-7	1994	Untreated K562 leukemia cells did not contain PAEP, whereas treatment of the cells with tetradecanoylphorbol acetate (TPA) induced strong expression of PAEP mRNA and synthesis of the intact protein that was found both in the cytoplasm of the differentiating cells and in the supernatant of TPA-treated cultures.	Tetradecanoylphorbol Acetate	290-293	progestagen associated endometrial protein	Homo sapiens	152-156
7516337-5	1994	It was possible, however, to activate Raf-1, MEK-1, and p42MAPK in J.CaM1 cells during treatment with the phorbol ester phorbol 12-myristate 13-acetate, which activates protein kinase C (PKC).	Tetradecanoylphorbol Acetate	120-151	mitogen-activated protein kinase kinase 1	Homo sapiens	45-50
8193353-13	1994	Phorbol diesters, including 12-0-tetradecanoyl phorbol 13-acetate (TPA), stabilize a variety of transiently expressed RNAs, including GM-CSF RNA.	Tetradecanoylphorbol Acetate	67-70	colony stimulating factor 2	Homo sapiens	134-140
8193353-14	1994	We found that TPA markedly increased (&gt; 30-fold) the accumulation of GM-CSF RNA.	Tetradecanoylphorbol Acetate	14-17	colony stimulating factor 2	Homo sapiens	72-78
8187833-0	1994	Phorbol ester TPA rapidly prevents activation of p34cdc2 histone H1 kinase and concomitantly the transition from G2 phase to mitosis in synchronized HeLa cells.	Tetradecanoylphorbol Acetate	14-17	cyclin dependent kinase 1	Homo sapiens	49-56
8187833-4	1994	Treatment of HeLa cells (synchronized around the G2-M transition) with TPA (10(-7) M) has now been shown to induce an overall decrease of the histone H1 kinase activity associated with anti-p34cdc2 immunoprecipitates after about 20 to 30 min.	Tetradecanoylphorbol Acetate	71-74	cyclin dependent kinase 1	Homo sapiens	190-197
8187833-8	1994	However, p34cdc2 from cultures treated with TPA was more intensely stained by anti-phosphotyrosine antibodies than that of control cells, indicating that TPA treatment probably prevented the tyrosine dephosphorylation required for expression of the histone H1 kinase activity of the complex.	Tetradecanoylphorbol Acetate	44-47	cyclin dependent kinase 1	Homo sapiens	9-16
8187833-8	1994	However, p34cdc2 from cultures treated with TPA was more intensely stained by anti-phosphotyrosine antibodies than that of control cells, indicating that TPA treatment probably prevented the tyrosine dephosphorylation required for expression of the histone H1 kinase activity of the complex.	Tetradecanoylphorbol Acetate	154-157	cyclin dependent kinase 1	Homo sapiens	9-16
8187833-9	1994	The results indicate that TPA treatment of HeLa cultures rapidly stops the G2-M transition because it very rapidly prevents the p34cdc2/Cyclin B complex in G2 cells from developing histone H1 kinase activity.	Tetradecanoylphorbol Acetate	26-29	cyclin dependent kinase 1	Homo sapiens	128-135
7948429-8	1994	Dibutyryl cAMP inhibited the PMA-induced release of TNF-R55-BP but not of TNF-R75-BP in both cell lines investigated.	Tetradecanoylphorbol Acetate	29-32	TNF receptor superfamily member 1A	Homo sapiens	52-59
8186261-3	1994	Administration of the phorbol ester TPA (12-O-tetradecanoylphorbol 13-acetate) which markedly elevates ornithine decarboxylase (ODC), did not potentiate putrescine export over what was measured in the unstimulated cultures.	Tetradecanoylphorbol Acetate	36-39	ornithine decarboxylase 1	Rattus norvegicus	103-126
8186261-3	1994	Administration of the phorbol ester TPA (12-O-tetradecanoylphorbol 13-acetate) which markedly elevates ornithine decarboxylase (ODC), did not potentiate putrescine export over what was measured in the unstimulated cultures.	Tetradecanoylphorbol Acetate	36-39	ornithine decarboxylase 1	Rattus norvegicus	128-131
8186261-3	1994	Administration of the phorbol ester TPA (12-O-tetradecanoylphorbol 13-acetate) which markedly elevates ornithine decarboxylase (ODC), did not potentiate putrescine export over what was measured in the unstimulated cultures.	Tetradecanoylphorbol Acetate	41-77	ornithine decarboxylase 1	Rattus norvegicus	103-126
8186261-3	1994	Administration of the phorbol ester TPA (12-O-tetradecanoylphorbol 13-acetate) which markedly elevates ornithine decarboxylase (ODC), did not potentiate putrescine export over what was measured in the unstimulated cultures.	Tetradecanoylphorbol Acetate	41-77	ornithine decarboxylase 1	Rattus norvegicus	128-131
8198544-2	1994	This gene construct contains the entire upstream regulatory sequence of c-fos, and expression of the endogenous and fusion gene was shown by Northern analysis to correlate upon induction with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	210-246	FBJ osteosarcoma oncogene	Mus musculus	72-77
7760840-2	1995	Nuclear run-on analysis showed that induction of uPA mRNA by CSF-1 and phorbol myristate acetate (PMA) was at the transcriptional level in bone marrow-derived macrophages.	Tetradecanoylphorbol Acetate	71-96	plasminogen activator, urokinase	Mus musculus	49-52
7760840-2	1995	Nuclear run-on analysis showed that induction of uPA mRNA by CSF-1 and phorbol myristate acetate (PMA) was at the transcriptional level in bone marrow-derived macrophages.	Tetradecanoylphorbol Acetate	98-101	plasminogen activator, urokinase	Mus musculus	49-52
7784060-5	1995	Four stably transfected clones, which expressed drastically reduced levels of OPN in the presence of both dexamethasone and TPA, were characterized.	Tetradecanoylphorbol Acetate	124-127	secreted phosphoprotein 1	Homo sapiens	78-81
7784060-6	1995	We found that (a) more than 20 copies of OPN antisense cDNA were stably incorporated into the genome of cells from two of these clones that were examined by Southern blot analysis; (b) dexamethasone-induced expression of antisense OPN RNA prevented augmented OPN expression at both mRNA and protein levels following TPA treatment; and (c) cells from all four clones failed to form colonies in soft agar medium containing both dexamethasone and TPA.	Tetradecanoylphorbol Acetate	316-319	secreted phosphoprotein 1	Homo sapiens	41-44
7784060-6	1995	We found that (a) more than 20 copies of OPN antisense cDNA were stably incorporated into the genome of cells from two of these clones that were examined by Southern blot analysis; (b) dexamethasone-induced expression of antisense OPN RNA prevented augmented OPN expression at both mRNA and protein levels following TPA treatment; and (c) cells from all four clones failed to form colonies in soft agar medium containing both dexamethasone and TPA.	Tetradecanoylphorbol Acetate	316-319	secreted phosphoprotein 1	Homo sapiens	231-234
7784060-6	1995	We found that (a) more than 20 copies of OPN antisense cDNA were stably incorporated into the genome of cells from two of these clones that were examined by Southern blot analysis; (b) dexamethasone-induced expression of antisense OPN RNA prevented augmented OPN expression at both mRNA and protein levels following TPA treatment; and (c) cells from all four clones failed to form colonies in soft agar medium containing both dexamethasone and TPA.	Tetradecanoylphorbol Acetate	316-319	secreted phosphoprotein 1	Homo sapiens	231-234
7784060-6	1995	We found that (a) more than 20 copies of OPN antisense cDNA were stably incorporated into the genome of cells from two of these clones that were examined by Southern blot analysis; (b) dexamethasone-induced expression of antisense OPN RNA prevented augmented OPN expression at both mRNA and protein levels following TPA treatment; and (c) cells from all four clones failed to form colonies in soft agar medium containing both dexamethasone and TPA.	Tetradecanoylphorbol Acetate	444-447	secreted phosphoprotein 1	Homo sapiens	41-44
7784060-6	1995	We found that (a) more than 20 copies of OPN antisense cDNA were stably incorporated into the genome of cells from two of these clones that were examined by Southern blot analysis; (b) dexamethasone-induced expression of antisense OPN RNA prevented augmented OPN expression at both mRNA and protein levels following TPA treatment; and (c) cells from all four clones failed to form colonies in soft agar medium containing both dexamethasone and TPA.	Tetradecanoylphorbol Acetate	444-447	secreted phosphoprotein 1	Homo sapiens	231-234
7784060-6	1995	We found that (a) more than 20 copies of OPN antisense cDNA were stably incorporated into the genome of cells from two of these clones that were examined by Southern blot analysis; (b) dexamethasone-induced expression of antisense OPN RNA prevented augmented OPN expression at both mRNA and protein levels following TPA treatment; and (c) cells from all four clones failed to form colonies in soft agar medium containing both dexamethasone and TPA.	Tetradecanoylphorbol Acetate	444-447	secreted phosphoprotein 1	Homo sapiens	231-234
7784060-7	1995	Taken together, these data demonstrate that inhibition of elevated OPN expression blocks TPA-induced anchorage-independent growth of JB6 c141.5a cells, suggesting the possibility that OPN overproduction is causally related to transformation of preneoplastic cells.	Tetradecanoylphorbol Acetate	89-92	secreted phosphoprotein 1	Homo sapiens	67-70
7784060-7	1995	Taken together, these data demonstrate that inhibition of elevated OPN expression blocks TPA-induced anchorage-independent growth of JB6 c141.5a cells, suggesting the possibility that OPN overproduction is causally related to transformation of preneoplastic cells.	Tetradecanoylphorbol Acetate	89-92	secreted phosphoprotein 1	Homo sapiens	184-187
7738037-3	1995	Long term exposure of 3T3-F442A adipocytes to phorbol 12-myristate 13-acetate (PMA) decreased beta 3-AR mRNA content in a time- and concentration-dependent manner, with maximal changes observed at 6 h (6.5-fold decrease) and at 100 nM PMA.	Tetradecanoylphorbol Acetate	46-77	adrenergic receptor, beta 3	Mus musculus	94-103
7738037-3	1995	Long term exposure of 3T3-F442A adipocytes to phorbol 12-myristate 13-acetate (PMA) decreased beta 3-AR mRNA content in a time- and concentration-dependent manner, with maximal changes observed at 6 h (6.5-fold decrease) and at 100 nM PMA.	Tetradecanoylphorbol Acetate	79-82	adrenergic receptor, beta 3	Mus musculus	94-103
7738037-9	1995	Inhibition of beta 3-AR mRNA by PMA was suppressed by the PKC-selective inhibitor bisindolylmaleimide, and was not observed in PKC-depleted cells, indicating that PKC was involved in this response.	Tetradecanoylphorbol Acetate	32-35	adrenergic receptor, beta 3	Mus musculus	14-23
7738037-11	1995	When 3T3-F442A adipocytes were pretreated with PMA for 24 h to down-regulate PKC, or with bisindolylmaleimide, the insulin-induced inhibition of beta 3-AR mRNA levels was reduced by 44-67%.	Tetradecanoylphorbol Acetate	47-50	adrenergic receptor, beta 3	Mus musculus	145-154
7544155-10	1995	Indeed, similar to metallothionein-1, RBTN-2 mRNA was induced in thymocytes of mice exposed to zinc and in human thymocytes treated with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	155-191	LIM domain only 2	Mus musculus	38-44
7590918-0	1995	Enzymatic activity of DPIV/CD26 is involved in PMA-induced hyperphosphorylation of p56lck.	Tetradecanoylphorbol Acetate	47-50	dipeptidyl peptidase 4	Homo sapiens	27-31
8198544-2	1994	This gene construct contains the entire upstream regulatory sequence of c-fos, and expression of the endogenous and fusion gene was shown by Northern analysis to correlate upon induction with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	248-251	FBJ osteosarcoma oncogene	Mus musculus	72-77
8198544-4	1994	In addition, we showed that epidermal keratinocytes responded to dialysed fetal bovine serum (FBS), TPA and high-calcium medium with enhanced Fos-lacZ expression and an inhibition of proliferation.	Tetradecanoylphorbol Acetate	100-103	FBJ osteosarcoma oncogene	Mus musculus	142-145
8198544-5	1994	The time course of induction of Fos-lacZ expression was similar for dialysed FBS and TPA, with a peak approximately 2 h after exposure.	Tetradecanoylphorbol Acetate	85-88	FBJ osteosarcoma oncogene	Mus musculus	32-35
7590918-0	1995	Enzymatic activity of DPIV/CD26 is involved in PMA-induced hyperphosphorylation of p56lck.	Tetradecanoylphorbol Acetate	47-50	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	83-89
8198544-8	1994	Thus, although our results indicate that the fos gene product may be involved in mediating epidermal keratinocyte growth arrest in response to differentiative agents such as FBS, TPA and high medium calcium levels, the exact role of this gene product remains unclear.	Tetradecanoylphorbol Acetate	179-182	FBJ osteosarcoma oncogene	Mus musculus	45-48
16169661-7	2006	Immunoprecipitation coupled with kinase assay demonstrated that MEK-1 activity was strongly induced by treatment of TPA for 5-30min in HepG2.	Tetradecanoylphorbol Acetate	116-119	mitogen-activated protein kinase kinase 1	Homo sapiens	64-69
16169661-9	2006	Consistently, Western blot of Phospho(ser-218/222)-MEK demonstrated that phosphorylation of MEK-1 was greatly induced by 50nM TPA, which can be prevented by the PKC inhibitor Bisindolylmaleimides II.	Tetradecanoylphorbol Acetate	126-129	mitogen-activated protein kinase kinase 1	Homo sapiens	92-97
8200066-7	1994	We postulate that the combined action of RA in causing decreased FN synthesis and increased FN binding to the cell surface is the reason for the apparent antagonism of RA to the TPA-stimulated release of FN.	Tetradecanoylphorbol Acetate	178-181	fibronectin 1	Mus musculus	65-67
8565712-7	1995	The study suggests that defectiveness of fibrinolytic system in CHD patients was shown mainly as disorder of tPA-PAI equilibrium and that decreased fibrinolytic activity and increased PAI in exercise-induced myocardial ischemia have relations with activation of platelets and renin-angiotensin system.	Tetradecanoylphorbol Acetate	109-112	serpin family B member 2	Homo sapiens	113-116
8200066-7	1994	We postulate that the combined action of RA in causing decreased FN synthesis and increased FN binding to the cell surface is the reason for the apparent antagonism of RA to the TPA-stimulated release of FN.	Tetradecanoylphorbol Acetate	178-181	fibronectin 1	Mus musculus	92-94
8200066-7	1994	We postulate that the combined action of RA in causing decreased FN synthesis and increased FN binding to the cell surface is the reason for the apparent antagonism of RA to the TPA-stimulated release of FN.	Tetradecanoylphorbol Acetate	178-181	fibronectin 1	Mus musculus	92-94
7539624-4	1995	Inducibility of the G-CSF receptor was studied by stimulation with interleukin-1 beta, tumour necrosis factor-alpha, Staphylococcus aureus Cowan A, anti-human IgM, phorbol myristate acetate, calcium ionophore A23187, and by infection in vitro by immortalizing and non-immortalizing strains of EBV.	Tetradecanoylphorbol Acetate	164-189	colony stimulating factor 3	Homo sapiens	20-25
16169661-10	2006	Moreover, pretreatment of the MEK1/2 inhibitor, but not c-Raf inhibitor prevented the TPA-induced ERK phosphorylation, gene expression of p15(INK4b) and p16 (INK4a) and growth inhibition of HepG2.	Tetradecanoylphorbol Acetate	86-89	mitogen-activated protein kinase kinase 1	Homo sapiens	30-36
16474181-6	2006	Resveratrol blunted TPA-induced phosphorylation of p65 and its interaction with CBP/p300, rendering NF-kappaB transcriptionally inactive.	Tetradecanoylphorbol Acetate	20-23	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	51-54
7895646-4	1995	In the present study, we address the role of GnRH and two second messenger activators, a phorbol ester (12-O-tetradecanoylphorbol-13-acetate) and forskolin, in the regulation of GnRH-R gene expression in the alpha T3-1 gonadotrope cell line.	Tetradecanoylphorbol Acetate	104-140	gonadotropin releasing hormone receptor	Mus musculus	178-184
16597486-9	2006	PMA induced ERK3 phosphorylation that was companied by an increase in ERK3/MAP2 association and MAP2 phosphorylation.	Tetradecanoylphorbol Acetate	0-3	microtubule-associated protein 2	Rattus norvegicus	75-79
7752674-0	1995	Upregulation of p21 RAS levels in HL-60 cells during differentiation induction with DMSO, all-trans-retinoic acid and TPA.	Tetradecanoylphorbol Acetate	118-121	HRas proto-oncogene, GTPase	Homo sapiens	16-23
7727044-5	1995	More detailed studies with TPA also revealed that multiple treatments (four over a 2-wk period) transiently elevated TGF alpha mRNA in both the epidermis and the dermis.	Tetradecanoylphorbol Acetate	27-30	transforming growth factor alpha	Mus musculus	117-126
8190095-7	1994	Measurement of LTC4 synthase enzymatic activity in cells challenged with A23187 and PMA in the presence or absence of staurosporine demonstrated that the activity of the LTC4 synthase enzyme was inhibited in cells costimulated with A23187 and PMA and that inhibition could also be completely prevented by the presence of staurosporine.	Tetradecanoylphorbol Acetate	84-87	leukotriene C4 synthase	Homo sapiens	15-28
8190095-7	1994	Measurement of LTC4 synthase enzymatic activity in cells challenged with A23187 and PMA in the presence or absence of staurosporine demonstrated that the activity of the LTC4 synthase enzyme was inhibited in cells costimulated with A23187 and PMA and that inhibition could also be completely prevented by the presence of staurosporine.	Tetradecanoylphorbol Acetate	84-87	leukotriene C4 synthase	Homo sapiens	170-183
8190095-7	1994	Measurement of LTC4 synthase enzymatic activity in cells challenged with A23187 and PMA in the presence or absence of staurosporine demonstrated that the activity of the LTC4 synthase enzyme was inhibited in cells costimulated with A23187 and PMA and that inhibition could also be completely prevented by the presence of staurosporine.	Tetradecanoylphorbol Acetate	243-246	leukotriene C4 synthase	Homo sapiens	170-183
8175715-4	1994	We demonstrated that the chimeric chloramphenicol acetyltransferase reporter constructs (the -103 to +1 sequence of the mouse lactoferrin gene) containing the mitogen-response unit of the lactoferrin gene were stimulated by cAMP, forskolin, 12-O-tetradecanoylphorbol-13-acetate, and epidermal growth factor/recombinant transforming growth factor-alpha (EGF/TGF-alpha) in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	241-277	lactotransferrin	Mus musculus	126-137
8175715-4	1994	We demonstrated that the chimeric chloramphenicol acetyltransferase reporter constructs (the -103 to +1 sequence of the mouse lactoferrin gene) containing the mitogen-response unit of the lactoferrin gene were stimulated by cAMP, forskolin, 12-O-tetradecanoylphorbol-13-acetate, and epidermal growth factor/recombinant transforming growth factor-alpha (EGF/TGF-alpha) in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	241-277	lactotransferrin	Mus musculus	188-199
7727044-6	1995	The time courses for changes in TGF alpha mRNA after multiple TPA treatments were similar for both tissues.	Tetradecanoylphorbol Acetate	62-65	transforming growth factor alpha	Mus musculus	32-41
16597486-9	2006	PMA induced ERK3 phosphorylation that was companied by an increase in ERK3/MAP2 association and MAP2 phosphorylation.	Tetradecanoylphorbol Acetate	0-3	microtubule-associated protein 2	Rattus norvegicus	96-100
7534073-5	1995	However, when protein kinase C (PKC) was either inhibited by the PKC inhibitor GF 109203X or depleted by a prolonged TPA treatment, the stimulation of MBP phosphorylation by EGF was strongly inhibited.	Tetradecanoylphorbol Acetate	117-120	epidermal growth factor	Homo sapiens	174-177
8175715-5	1994	The sequence at position -52 to -40 (mLF-CRE) of the gene conferred transcriptional activation in the presence of forskolin, cyclic AMP, and 12-O-tetradecanoylphorbol-13-acetate in transiently transfected human endometrium carcinoma RL95-2 cells, whereas the region at -80 to -60 responded to EGF/TGF-alpha stimulation.	Tetradecanoylphorbol Acetate	141-177	epidermal growth factor	Homo sapiens	293-296
16741047-7	2006	Serum withdrawal from the incubation medium as well as addition of carbachol or PMA for 24 hrs also led to a significant reduction of the levels of ECE-1 protein in NB7 cells.	Tetradecanoylphorbol Acetate	80-83	endothelin converting enzyme 1	Homo sapiens	148-153
8161795-7	1994	Secretion and mRNA expression of M-CSF by 12-0-tetradecanoylphorbol-13-acetate (TPA)-treated THP-1 cells (human monocytic leukemia cell line) and TPA-treated HL-60 cells (human promyelocytic leukemia cell line) were also increased by 1 alpha,25(OH)2D3.	Tetradecanoylphorbol Acetate	80-83	colony stimulating factor 1	Homo sapiens	33-38
8161795-8	1994	M-CSF secretion from TPA-treated THP-1 cells was increased by 1 alpha,25(OH)2D3 in a dose-dependent and metabolite-specific manner.	Tetradecanoylphorbol Acetate	21-24	colony stimulating factor 1	Homo sapiens	0-5
7794791-2	1995	HL60 cells are able to differentiate into a granulocytic lineage by prolonged exposure to retinoids and into a macrophage-like lineage by exposure to tumor promoter 12-O-tetradecanoylphorbol 13-acetate, with a rapid decrease of c-myc gene expression.	Tetradecanoylphorbol Acetate	165-201	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	228-233
7867591-4	1995	After 8 h of treatment TPA and forskolin increase the steady-state level of NPY mRNA 10- and 12-fold in LA-N-5 and PC12 cells, respectively.	Tetradecanoylphorbol Acetate	23-26	neuropeptide Y	Homo sapiens	76-79
7867591-8	1995	Thus, these experiments demonstrate that TPA and forskolin effect the regulation of the NPY gene via transcriptional and posttranscriptional mechanisms in a cell-specific manner.	Tetradecanoylphorbol Acetate	41-44	neuropeptide Y	Homo sapiens	88-91
16376386-0	2006	Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappaB activation in U937 cells.	Tetradecanoylphorbol Acetate	19-22	C-C motif chemokine ligand 2	Homo sapiens	40-45
7867606-1	1995	The dog thyrocyte I- trapping activity and the expression of the genes coding for dog thyrocyte thyroglobulin or thyroid peroxidase are enhanced by TSH through the cAMP cascade and reduced by mitogens such as epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	242-278	thyroglobulin	Canis lupus familiaris	96-109
7867606-1	1995	The dog thyrocyte I- trapping activity and the expression of the genes coding for dog thyrocyte thyroglobulin or thyroid peroxidase are enhanced by TSH through the cAMP cascade and reduced by mitogens such as epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	280-283	thyroglobulin	Canis lupus familiaris	96-109
8144669-1	1994	The 47-kDa subunit of the NADPH oxidase system (p47-phox) of neutrophils undergoes an association with proteins in the Triton X-100-insoluble fraction upon stimulation of the cells with 4 beta-phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	188-224	pleckstrin	Homo sapiens	48-51
7884324-11	1995	This is the first report of the presence of TCTP in hemopoietic cells and its modulation by PMA or LPS in any cell type.	Tetradecanoylphorbol Acetate	92-95	tumor protein, translationally-controlled 1	Homo sapiens	44-48
16522634-5	2006	Clcn3(-/-) PMNs displayed markedly reduced NADPH oxidase activity in response to opsonized zymosan and modestly reduced activity after phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	135-166	chloride voltage-gated channel 3	Homo sapiens	0-5
7545319-2	1995	In response to bacterial lipopolysaccharide (LPS) and phorbol-12 myristate 13-acetate (PMA), monocytes synthesize and express TF on their surface.	Tetradecanoylphorbol Acetate	54-85	coagulation factor III, tissue factor	Homo sapiens	126-128
7545319-2	1995	In response to bacterial lipopolysaccharide (LPS) and phorbol-12 myristate 13-acetate (PMA), monocytes synthesize and express TF on their surface.	Tetradecanoylphorbol Acetate	87-90	coagulation factor III, tissue factor	Homo sapiens	126-128
7545319-3	1995	However, the mechanisms by which LPS and PMA activate TF synthesis by human blood monocytes are not fully understood.	Tetradecanoylphorbol Acetate	41-44	coagulation factor III, tissue factor	Homo sapiens	54-56
7545319-4	1995	As it has been established that LPS and PMA activate protein tyrosine kinase (PTK) in monocytes, we studied the role of PTK in LPS and PMA induction of TF by human blood monocytes.	Tetradecanoylphorbol Acetate	40-43	protein tyrosine kinase 2 beta	Homo sapiens	78-81
7545319-4	1995	As it has been established that LPS and PMA activate protein tyrosine kinase (PTK) in monocytes, we studied the role of PTK in LPS and PMA induction of TF by human blood monocytes.	Tetradecanoylphorbol Acetate	135-138	coagulation factor III, tissue factor	Homo sapiens	152-154
8143789-9	1994	These results demonstrated that transient stimulation of HT1080 cells by TPA with subsequent exposure to cAMP is sufficient for the synergistic induction of the activin A gene expression and suggested that the combinatorial action of TPA followed by cAMP stimulation plays an important role in regulating activin synthesis in these cells.	Tetradecanoylphorbol Acetate	234-237	inhibin subunit beta E	Homo sapiens	161-168
7545319-5	1995	Both LPS- and PMA-induced TF activity was inhibited in a concentration-dependent manner by the protein tyrosine kinase-specific inhibitors herbimycin A and genistein.	Tetradecanoylphorbol Acetate	14-17	coagulation factor III, tissue factor	Homo sapiens	26-28
16396605-1	2006	A fluorescence imaging technique was used to monitor intracellular localization of protein kinase C (PKC) in U-87 MG human glioma cells in the presence of hypericin (Hyp) and phorbol 12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	175-206	protein kinase C gamma	Homo sapiens	101-104
7545319-6	1995	TF antigen determination confirmed that LPS- and PMA-induced cell surface TF protein levels decreased in parallel to TF functional activity under herbimycin A and genistein treatment.	Tetradecanoylphorbol Acetate	49-52	coagulation factor III, tissue factor	Homo sapiens	0-2
7545319-6	1995	TF antigen determination confirmed that LPS- and PMA-induced cell surface TF protein levels decreased in parallel to TF functional activity under herbimycin A and genistein treatment.	Tetradecanoylphorbol Acetate	49-52	coagulation factor III, tissue factor	Homo sapiens	74-76
7545319-6	1995	TF antigen determination confirmed that LPS- and PMA-induced cell surface TF protein levels decreased in parallel to TF functional activity under herbimycin A and genistein treatment.	Tetradecanoylphorbol Acetate	49-52	coagulation factor III, tissue factor	Homo sapiens	74-76
7545319-9	1995	We conclude that LPS- and PMA-induced TF production by human monocytes is dependent on tyrosine kinase activation.	Tetradecanoylphorbol Acetate	26-29	coagulation factor III, tissue factor	Homo sapiens	38-40
8150544-4	1994	However, both TPA and the calcium ionophore A23187 were similarly effective in inducing fos-mRNA in both cell lines.	Tetradecanoylphorbol Acetate	14-17	FBJ osteosarcoma oncogene	Mus musculus	88-91
7908680-2	1994	We have studied the regulation of keratinocyte transglutaminase (TGK) gene expression in murine epidermal keratinocytes induced to terminally differentiate in vitro by increasing the level of extracellular Ca++ or treatment with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	266-302	transglutaminase 1, K polypeptide	Mus musculus	65-68
7908680-2	1994	We have studied the regulation of keratinocyte transglutaminase (TGK) gene expression in murine epidermal keratinocytes induced to terminally differentiate in vitro by increasing the level of extracellular Ca++ or treatment with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	304-307	transglutaminase 1, K polypeptide	Mus musculus	65-68
7908680-4	1994	TPA induces squamous differentiation and TGK mRNA even in basal keratinocyte cultures grown in 0.05 mM Ca++ medium, suggesting that expression of this differentiation marker is regulated by the PKC signaling pathway.	Tetradecanoylphorbol Acetate	0-3	transglutaminase 1, K polypeptide	Mus musculus	41-44
7908680-5	1994	Induction of TGK mRNA in response to TPA treatment is transient, reaching a peak at 6-8 h and returning to baseline by 24 h. In contrast, elevation of TGK mRNA levels in response to Ca++ persists for at least 24 h. The increased abundance of TGK mRNA reflects increased transcription of the TGK gene, based on nuclear run-on analysis of Ca(++)- and TPA-treated keratinocytes.	Tetradecanoylphorbol Acetate	37-40	transglutaminase 1, K polypeptide	Mus musculus	13-16
7908680-5	1994	Induction of TGK mRNA in response to TPA treatment is transient, reaching a peak at 6-8 h and returning to baseline by 24 h. In contrast, elevation of TGK mRNA levels in response to Ca++ persists for at least 24 h. The increased abundance of TGK mRNA reflects increased transcription of the TGK gene, based on nuclear run-on analysis of Ca(++)- and TPA-treated keratinocytes.	Tetradecanoylphorbol Acetate	37-40	transglutaminase 1, K polypeptide	Mus musculus	151-154
7908680-5	1994	Induction of TGK mRNA in response to TPA treatment is transient, reaching a peak at 6-8 h and returning to baseline by 24 h. In contrast, elevation of TGK mRNA levels in response to Ca++ persists for at least 24 h. The increased abundance of TGK mRNA reflects increased transcription of the TGK gene, based on nuclear run-on analysis of Ca(++)- and TPA-treated keratinocytes.	Tetradecanoylphorbol Acetate	37-40	transglutaminase 1, K polypeptide	Mus musculus	151-154
7876145-5	1995	Down-regulation of PKC by prolonged treatment with 4 beta-phorbol 12-myristate 13-acetate also abolished EGF- and PDGF-stimulated phosphatidylbutanol formation.	Tetradecanoylphorbol Acetate	51-89	epidermal growth factor	Mus musculus	105-108
16396605-1	2006	A fluorescence imaging technique was used to monitor intracellular localization of protein kinase C (PKC) in U-87 MG human glioma cells in the presence of hypericin (Hyp) and phorbol 12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	208-211	protein kinase C gamma	Homo sapiens	101-104
7908680-5	1994	Induction of TGK mRNA in response to TPA treatment is transient, reaching a peak at 6-8 h and returning to baseline by 24 h. In contrast, elevation of TGK mRNA levels in response to Ca++ persists for at least 24 h. The increased abundance of TGK mRNA reflects increased transcription of the TGK gene, based on nuclear run-on analysis of Ca(++)- and TPA-treated keratinocytes.	Tetradecanoylphorbol Acetate	37-40	transglutaminase 1, K polypeptide	Mus musculus	151-154
7908680-5	1994	Induction of TGK mRNA in response to TPA treatment is transient, reaching a peak at 6-8 h and returning to baseline by 24 h. In contrast, elevation of TGK mRNA levels in response to Ca++ persists for at least 24 h. The increased abundance of TGK mRNA reflects increased transcription of the TGK gene, based on nuclear run-on analysis of Ca(++)- and TPA-treated keratinocytes.	Tetradecanoylphorbol Acetate	349-352	transglutaminase 1, K polypeptide	Mus musculus	13-16
7908680-5	1994	Induction of TGK mRNA in response to TPA treatment is transient, reaching a peak at 6-8 h and returning to baseline by 24 h. In contrast, elevation of TGK mRNA levels in response to Ca++ persists for at least 24 h. The increased abundance of TGK mRNA reflects increased transcription of the TGK gene, based on nuclear run-on analysis of Ca(++)- and TPA-treated keratinocytes.	Tetradecanoylphorbol Acetate	349-352	transglutaminase 1, K polypeptide	Mus musculus	151-154
7756180-6	1995	The cDNA for this enzyme was cloned from the differentiated Reh cells, and the UCH-L1 mRNA was detected in both parent and 12-O-tetradecanoylphorbol-13-acetate-induced cells.	Tetradecanoylphorbol Acetate	123-159	ubiquitin C-terminal hydrolase L1	Homo sapiens	79-85
16643793-1	2006	AIM: To investigate the expression of CD147 both on cellular membrane and in culture supernatant of in vitro cultured THP-1 cells and monocytes of RA patients before and after stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	193-218	basigin (Ok blood group)	Homo sapiens	38-43
7821434-0	1995	PMA-induced down-regulation of the receptor for alpha 2-macroglobulin in human U937 cells.	Tetradecanoylphorbol Acetate	0-3	alpha-2-macroglobulin	Homo sapiens	48-69
7821434-3	1995	Ligand blotting experiments with the 39 kDa receptor-associated protein RAP, a ligand for alpha 2-MR, indicated that alpha 2-MR levels first increased and then decreased after PMA treatment.	Tetradecanoylphorbol Acetate	176-179	LDL receptor related protein associated protein 1	Homo sapiens	37-71
7821434-3	1995	Ligand blotting experiments with the 39 kDa receptor-associated protein RAP, a ligand for alpha 2-MR, indicated that alpha 2-MR levels first increased and then decreased after PMA treatment.	Tetradecanoylphorbol Acetate	176-179	LDL receptor related protein associated protein 1	Homo sapiens	72-75
7822270-8	1995	Furthermore, the p85 subunit of phosphatidylinositol-3-OH kinase (PI3 kinase) co-precipitated with the small isoform of the HGF receptor, and this association was dramatically inhibited by treatment with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	204-240	met proto-oncogene	Mus musculus	124-136
7835430-5	1995	We observed that NGF, PMA and cAMP induce the phosphorylation of B-Raf as well as an upward shift in its electrophoretic mobility.	Tetradecanoylphorbol Acetate	22-25	B-Raf proto-oncogene, serine/threonine kinase	Rattus norvegicus	65-70
8146596-3	1994	In combination with submitogenic concentrations of phorbol esters (PMA); LD6 MoAb was able to induce accumulation of mRNA specific for GM-CSF, gamma-IFN and TNF-alpha and release of these cytokines by LD6+ T-cell lines.	Tetradecanoylphorbol Acetate	67-70	colony stimulating factor 2	Homo sapiens	135-141
7510705-6	1994	We found that bFGF and a protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate, significantly induced luciferase activity driven by the LDL receptor promoter, whereas 25-hydroxycholesterol reduced the luciferase activity in bFGF-stimulated cells.	Tetradecanoylphorbol Acetate	59-90	low density lipoprotein receptor	Homo sapiens	148-160
16643793-1	2006	AIM: To investigate the expression of CD147 both on cellular membrane and in culture supernatant of in vitro cultured THP-1 cells and monocytes of RA patients before and after stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	220-223	basigin (Ok blood group)	Homo sapiens	38-43
8142362-1	1994	Plasminogen activator inhibitor 1 (PAI-1), a member of the serine protease inhibitor (Serpin) superfamily, is the primary inhibitor of the plasminogen activators tPA and uPA.	Tetradecanoylphorbol Acetate	162-165	serpin family E member 1	Homo sapiens	0-33
16600024-8	2006	Phorbol myristate acetate-stimulated oxidative burst and IL-8 release by IL-1beta, lipopolysaccharide and GM-CSF in whole blood from mild but not severe asthmatics were inhibited after prednisolone.	Tetradecanoylphorbol Acetate	0-25	colony stimulating factor 2	Homo sapiens	106-112
8142362-1	1994	Plasminogen activator inhibitor 1 (PAI-1), a member of the serine protease inhibitor (Serpin) superfamily, is the primary inhibitor of the plasminogen activators tPA and uPA.	Tetradecanoylphorbol Acetate	162-165	serpin family E member 1	Homo sapiens	35-40
8142369-4	1994	Addition of the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol 13-acetate (TPA), or the Ca2+ ionophore, ionomycin, mimicked the profile of GnRH-induced alpha and LH beta mRNA elevation.	Tetradecanoylphorbol Acetate	50-86	gonadotropin releasing hormone 1	Rattus norvegicus	152-156
8135780-1	1994	Two cis-acting elements GM-kappa B/GC-box and CLE0, of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene are required for maximal induction in Jurkat T cells by costimulation with phorbol-12-myristate acetate (PMA) and Ca2+ ionophore (A23187).	Tetradecanoylphorbol Acetate	227-230	colony stimulating factor 2	Homo sapiens	59-107
8135780-1	1994	Two cis-acting elements GM-kappa B/GC-box and CLE0, of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene are required for maximal induction in Jurkat T cells by costimulation with phorbol-12-myristate acetate (PMA) and Ca2+ ionophore (A23187).	Tetradecanoylphorbol Acetate	227-230	colony stimulating factor 2	Homo sapiens	109-115
8580531-3	1995	Furthermore, preincubation of the tissue with PMA prevents the IL-2 effect, suggesting that the kinases activated by the tumor promoter and IL-2 share a common substrate.	Tetradecanoylphorbol Acetate	46-49	interleukin 2	Rattus norvegicus	63-67
8580531-3	1995	Furthermore, preincubation of the tissue with PMA prevents the IL-2 effect, suggesting that the kinases activated by the tumor promoter and IL-2 share a common substrate.	Tetradecanoylphorbol Acetate	46-49	interleukin 2	Rattus norvegicus	140-144
7811465-6	1995	In contrast, phorbol myristate acetate, a nonphysiologic leukocyte activator, was significantly less effective in stimulating either enhanced MCP-1 mRNA expression or secretion of MCP-1.	Tetradecanoylphorbol Acetate	13-38	C-C motif chemokine ligand 2	Rattus norvegicus	142-147
16630119-2	2006	After stimulation with 50 nM phorbol 12-myristate 13-acetate (PMA), the cells differentiated into cells with mesenchymal characteristics and upregulated Dmrt-1 mRNA, possibly through the protein kinase C/mitogen-activated protein kinase/activated protein-1 signaling pathway.	Tetradecanoylphorbol Acetate	29-60	doublesex and mab-3 related transcription factor 1	Homo sapiens	153-159
7811465-6	1995	In contrast, phorbol myristate acetate, a nonphysiologic leukocyte activator, was significantly less effective in stimulating either enhanced MCP-1 mRNA expression or secretion of MCP-1.	Tetradecanoylphorbol Acetate	13-38	C-C motif chemokine ligand 2	Rattus norvegicus	180-185
7640049-6	1995	Coincident with these changes, TPA induced phosphorylation of alpha-6 integrin, whereas temozolomide or calphostin c abolished the appearance of this phosphoprotein.	Tetradecanoylphorbol Acetate	31-34	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	62-69
8018558-2	1994	Differentiation of U-937 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of the serine/threonine protein kinase C, was associated with transcriptional activation of EGR-1 promoter-reporter constructs.	Tetradecanoylphorbol Acetate	36-72	early growth response 1	Homo sapiens	185-190
8018558-2	1994	Differentiation of U-937 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of the serine/threonine protein kinase C, was associated with transcriptional activation of EGR-1 promoter-reporter constructs.	Tetradecanoylphorbol Acetate	74-77	early growth response 1	Homo sapiens	185-190
8206325-3	1994	Analysis of the half-life of GnRH mRNA levels after transcriptional arrest with actinomycin-D (5 micrograms/ml) estimated the half-life of GnRH mRNA to be 22 h. TPA treatment did not alter the GnRH mRNA half-life directly, suggesting that the effects of TPA occur predominantly at the level of gene transcription.	Tetradecanoylphorbol Acetate	161-164	gonadotropin releasing hormone 1	Rattus norvegicus	139-143
8206325-3	1994	Analysis of the half-life of GnRH mRNA levels after transcriptional arrest with actinomycin-D (5 micrograms/ml) estimated the half-life of GnRH mRNA to be 22 h. TPA treatment did not alter the GnRH mRNA half-life directly, suggesting that the effects of TPA occur predominantly at the level of gene transcription.	Tetradecanoylphorbol Acetate	161-164	gonadotropin releasing hormone 1	Rattus norvegicus	139-143
8206325-4	1994	Exposure of cells transiently transfected with various deletion constructs of the rat (r)GnRH promoter to TPA resulted in a decrease of 60% in luciferase reporter activity.	Tetradecanoylphorbol Acetate	106-109	gonadotropin releasing hormone 1	Rattus norvegicus	89-93
7750926-0	1995	Persistent growth of BALB/C mouse plasmacytoma and human myeloma cell lines in the presence of phorbol myristate acetate is associated with continued expression of Lap18 (stathmin).	Tetradecanoylphorbol Acetate	95-120	stathmin 1	Homo sapiens	164-169
7750926-0	1995	Persistent growth of BALB/C mouse plasmacytoma and human myeloma cell lines in the presence of phorbol myristate acetate is associated with continued expression of Lap18 (stathmin).	Tetradecanoylphorbol Acetate	95-120	stathmin 1	Homo sapiens	171-179
16630119-2	2006	After stimulation with 50 nM phorbol 12-myristate 13-acetate (PMA), the cells differentiated into cells with mesenchymal characteristics and upregulated Dmrt-1 mRNA, possibly through the protein kinase C/mitogen-activated protein kinase/activated protein-1 signaling pathway.	Tetradecanoylphorbol Acetate	62-65	doublesex and mab-3 related transcription factor 1	Homo sapiens	153-159
16630052-7	2006	(3) Both PKC and PKA potentiated release when they were specifically stimulated [with phorbol 12-myristate 13-acetate (PMA) and Sp-8-Br cAMPs, respectively], and both needed the P/Q channel.	Tetradecanoylphorbol Acetate	86-117	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	17-20
7822950-6	1995	Furthermore, prior downregulation of PKC to less than 1% of basal activity by exposure of MCs to 0.5 mumol/L phorbol myristate acetate (PMA) also prevented LDL stimulation of fibronectin synthesis.	Tetradecanoylphorbol Acetate	109-134	fibronectin 1	Rattus norvegicus	175-186
7822950-6	1995	Furthermore, prior downregulation of PKC to less than 1% of basal activity by exposure of MCs to 0.5 mumol/L phorbol myristate acetate (PMA) also prevented LDL stimulation of fibronectin synthesis.	Tetradecanoylphorbol Acetate	136-139	fibronectin 1	Rattus norvegicus	175-186
8112895-9	1994	PKC-epsilon was completely down-regulated by exposure to 10 nM bryostatin I for 18 hr or to TPA for 24 hr.	Tetradecanoylphorbol Acetate	92-95	protein kinase C epsilon	Homo sapiens	0-11
16630052-7	2006	(3) Both PKC and PKA potentiated release when they were specifically stimulated [with phorbol 12-myristate 13-acetate (PMA) and Sp-8-Br cAMPs, respectively], and both needed the P/Q channel.	Tetradecanoylphorbol Acetate	119-122	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	17-20
8867671-4	1995	Two copies of the IRF-1 kappa B site fused to the heterologous c-fos promoter conferred induction of a chloramphenicol acetyl transferase (CAT) reported gene in response to stimulation of L929 fibroblasts with various NF-kappa B inducers, such as tumor necrosis factor alpha (TNF alpha) or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	290-321	interferon regulatory factor 1	Mus musculus	18-23
16472984-4	2006	RESULTS: Levels of IL-2 mRNA in phorbol 12-myristate 13-acetate/ionomycin activated splenocytes and cytokine in T-helper-1 cells were increased by 50 microM of alphaTOC but decreased by 1 mM of alphaTOC.	Tetradecanoylphorbol Acetate	32-63	interleukin 2	Mus musculus	19-23
21043585-6	1995	C-myc expression was turned off by TPA (16 nM) stimulation of cells within 2-4 h. This TPA-mediated effect likely occurred at the transcriptional level since the half life of c-myc mRN A induced by GM-CSF was less than 30 min.	Tetradecanoylphorbol Acetate	35-38	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	175-180
21043585-6	1995	C-myc expression was turned off by TPA (16 nM) stimulation of cells within 2-4 h. This TPA-mediated effect likely occurred at the transcriptional level since the half life of c-myc mRN A induced by GM-CSF was less than 30 min.	Tetradecanoylphorbol Acetate	35-38	colony stimulating factor 2	Homo sapiens	198-204
21043585-6	1995	C-myc expression was turned off by TPA (16 nM) stimulation of cells within 2-4 h. This TPA-mediated effect likely occurred at the transcriptional level since the half life of c-myc mRN A induced by GM-CSF was less than 30 min.	Tetradecanoylphorbol Acetate	87-90	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
21043585-6	1995	C-myc expression was turned off by TPA (16 nM) stimulation of cells within 2-4 h. This TPA-mediated effect likely occurred at the transcriptional level since the half life of c-myc mRN A induced by GM-CSF was less than 30 min.	Tetradecanoylphorbol Acetate	87-90	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	175-180
8191411-2	1994	The induction of TF synthesis and activity on the surface of endothelial cell membrane is initiated by lipopolysaccharide (LPS), phorbol 12-myristate 13-O-acetate (PMA), and inflammatory factors such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF alpha).	Tetradecanoylphorbol Acetate	164-167	coagulation factor III, tissue factor	Homo sapiens	17-19
8106362-8	1994	TPA also induces translocation of PKC beta to the nuclear membrane.	Tetradecanoylphorbol Acetate	0-3	protein kinase C beta	Bos taurus	34-42
8180129-9	1994	A 72-h treatment with one nM TPA maximally increased expression of c-jun, krox-24, and jun-B mRNA transcripts.	Tetradecanoylphorbol Acetate	29-32	early growth response 1	Homo sapiens	74-81
21043585-6	1995	C-myc expression was turned off by TPA (16 nM) stimulation of cells within 2-4 h. This TPA-mediated effect likely occurred at the transcriptional level since the half life of c-myc mRN A induced by GM-CSF was less than 30 min.	Tetradecanoylphorbol Acetate	87-90	colony stimulating factor 2	Homo sapiens	198-204
16184549-5	2006	Moreover, overexpression of very high amounts of PKCepsilon sensitized LNCaP cells to induction of apoptosis by bryostatin 1, a non tumor-promoting activator and down-regulator of PKC isozymes that blocks PMA-induced apoptosis of parental LNCaP cells, mimicked our previous results with overexpression of PKCalpha in LNCaP cells.	Tetradecanoylphorbol Acetate	205-208	protein kinase C epsilon	Homo sapiens	49-59
21043585-10	1995	These studies suggest a link between PKC stimulation by TPA and AP-1 activation with downregulation of c-myc transcription on a molecular level.	Tetradecanoylphorbol Acetate	56-59	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	103-108
21043771-5	1995	Greater CD63 and CD62P expression were induced by phorbol myristate acetate (1.6 pM, 70.9 +- 11% and 69.4 +- 9.9%, respectively) and thrombin (0.1 U/ml, 70.7 +- 9.3% and 73.5 +- 5.4%, respectively).	Tetradecanoylphorbol Acetate	50-75	CD63 molecule	Homo sapiens	8-12
8193081-10	1994	Stimulation of NHKs with phorbol 12-myristate 13-acetate(PMA) and lipopolysaccharide(LPS) resulted in an increase of IL-8 and decrease of IL-1 alpha in the culture supernatants.	Tetradecanoylphorbol Acetate	25-56	interleukin 1 alpha	Homo sapiens	138-148
8193081-10	1994	Stimulation of NHKs with phorbol 12-myristate 13-acetate(PMA) and lipopolysaccharide(LPS) resulted in an increase of IL-8 and decrease of IL-1 alpha in the culture supernatants.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 alpha	Homo sapiens	138-148
21043771-5	1995	Greater CD63 and CD62P expression were induced by phorbol myristate acetate (1.6 pM, 70.9 +- 11% and 69.4 +- 9.9%, respectively) and thrombin (0.1 U/ml, 70.7 +- 9.3% and 73.5 +- 5.4%, respectively).	Tetradecanoylphorbol Acetate	50-75	selectin P	Homo sapiens	17-22
8177492-2	1994	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) significantly potentiated cAMP accumulation in response to the adenosine analog N6-R-phenyl-isopropyl adenosine (PIA) and to forskolin.	Tetradecanoylphorbol Acetate	23-54	RPTOR independent companion of MTOR complex 2	Homo sapiens	141-172
16244358-5	2006	BPDE treatment induced p53 accumulation which was attenuated significantly by TPA.	Tetradecanoylphorbol Acetate	78-81	transformation related protein 53, pseudogene	Mus musculus	23-26
8177492-2	1994	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) significantly potentiated cAMP accumulation in response to the adenosine analog N6-R-phenyl-isopropyl adenosine (PIA) and to forskolin.	Tetradecanoylphorbol Acetate	23-54	RPTOR independent companion of MTOR complex 2	Homo sapiens	174-177
8177492-2	1994	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) significantly potentiated cAMP accumulation in response to the adenosine analog N6-R-phenyl-isopropyl adenosine (PIA) and to forskolin.	Tetradecanoylphorbol Acetate	56-59	RPTOR independent companion of MTOR complex 2	Homo sapiens	141-172
8177492-2	1994	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) significantly potentiated cAMP accumulation in response to the adenosine analog N6-R-phenyl-isopropyl adenosine (PIA) and to forskolin.	Tetradecanoylphorbol Acetate	56-59	RPTOR independent companion of MTOR complex 2	Homo sapiens	174-177
7569060-3	1995	PMA (10 ng mL-1) inhibited gonadotrophin-induced granulosa cell steroidogenesis and cAMP accumulation.	Tetradecanoylphorbol Acetate	0-3	L1 cell adhesion molecule	Mus musculus	11-15
7569060-5	1995	The inhibitory effect of PMA (10 ng mL-1) on gonadotrophin-induced granulosa cell steroidogenesis was not present in PKC-down-regulated cells.	Tetradecanoylphorbol Acetate	25-28	L1 cell adhesion molecule	Mus musculus	36-40
16244358-6	2006	Cells treated with BPDE and TPA showed increased ratio of Mdm2 to p53 proteins in p53 immunoprecipitate and decreased p53 life span compared to BPDE-treated cells indicating p53 destabilization by TPA.	Tetradecanoylphorbol Acetate	28-31	transformed mouse 3T3 cell double minute 2	Mus musculus	58-62
16244358-6	2006	Cells treated with BPDE and TPA showed increased ratio of Mdm2 to p53 proteins in p53 immunoprecipitate and decreased p53 life span compared to BPDE-treated cells indicating p53 destabilization by TPA.	Tetradecanoylphorbol Acetate	28-31	transformation related protein 53, pseudogene	Mus musculus	66-69
7891669-2	1994	The expression of MCP-1 gene can be induced by lipopolysaccharides (LPS), phorbol esters (TPA) and several cytokines.	Tetradecanoylphorbol Acetate	90-93	C-C motif chemokine ligand 2	Homo sapiens	18-23
16244358-6	2006	Cells treated with BPDE and TPA showed increased ratio of Mdm2 to p53 proteins in p53 immunoprecipitate and decreased p53 life span compared to BPDE-treated cells indicating p53 destabilization by TPA.	Tetradecanoylphorbol Acetate	28-31	transformation related protein 53, pseudogene	Mus musculus	82-85
7891669-4	1994	We tested whether the two putative TPA-responsive elements (TREs) and one kappa B enhancer-like region found in the MCP-1 promoter region, are involved in this regulation of MCP-1 gene expression.	Tetradecanoylphorbol Acetate	35-38	C-C motif chemokine ligand 2	Homo sapiens	174-179
16244358-6	2006	Cells treated with BPDE and TPA showed increased ratio of Mdm2 to p53 proteins in p53 immunoprecipitate and decreased p53 life span compared to BPDE-treated cells indicating p53 destabilization by TPA.	Tetradecanoylphorbol Acetate	28-31	transformation related protein 53, pseudogene	Mus musculus	82-85
7891669-5	1994	The 5" untranslated region of MCP-1 gene was linked to chloramphenicol acetyl transferase (CAT) reporter gene and transfected into human glioblastoma cells in which endogenous MCP gene expression was found to be stimulated by TPA and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	226-229	C-C motif chemokine ligand 2	Homo sapiens	30-35
7864662-8	1994	Treatment with 10 nM TPA, which also induces keratinocyte differentiation, reduced c-myc RNA levels to 70% of control levels during the first 4 h, but thereafter c-myc levels remained approximately constant for a further 20 h. TGF beta (2 ng/ml), which inhibits keratinocyte growth without inducing differentiation, did not alter c-myc RNA levels over a 4-day period.	Tetradecanoylphorbol Acetate	21-24	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	83-88
16244358-6	2006	Cells treated with BPDE and TPA showed increased ratio of Mdm2 to p53 proteins in p53 immunoprecipitate and decreased p53 life span compared to BPDE-treated cells indicating p53 destabilization by TPA.	Tetradecanoylphorbol Acetate	28-31	transformation related protein 53, pseudogene	Mus musculus	82-85
7864662-8	1994	Treatment with 10 nM TPA, which also induces keratinocyte differentiation, reduced c-myc RNA levels to 70% of control levels during the first 4 h, but thereafter c-myc levels remained approximately constant for a further 20 h. TGF beta (2 ng/ml), which inhibits keratinocyte growth without inducing differentiation, did not alter c-myc RNA levels over a 4-day period.	Tetradecanoylphorbol Acetate	21-24	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	162-167
7891669-5	1994	The 5" untranslated region of MCP-1 gene was linked to chloramphenicol acetyl transferase (CAT) reporter gene and transfected into human glioblastoma cells in which endogenous MCP gene expression was found to be stimulated by TPA and tumor necrosis factor-alpha (TNF-alpha).	Tetradecanoylphorbol Acetate	226-229	capping actin protein, gelsolin like	Homo sapiens	30-33
16244358-7	2006	TPA also inhibited BPDE-induced p53 phosphorylation at serine15.	Tetradecanoylphorbol Acetate	0-3	transformation related protein 53, pseudogene	Mus musculus	32-35
7891669-6	1994	The 128 bp 5"-flanking region containing one TRE was adequate for basal promoter activity but the presence of both TREs in the MCP-1 promoter region were needed to give TPA responsive enhancement (2.5 fold) of expression of the marker gene.	Tetradecanoylphorbol Acetate	169-172	C-C motif chemokine ligand 2	Homo sapiens	127-132
7864662-8	1994	Treatment with 10 nM TPA, which also induces keratinocyte differentiation, reduced c-myc RNA levels to 70% of control levels during the first 4 h, but thereafter c-myc levels remained approximately constant for a further 20 h. TGF beta (2 ng/ml), which inhibits keratinocyte growth without inducing differentiation, did not alter c-myc RNA levels over a 4-day period.	Tetradecanoylphorbol Acetate	21-24	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	162-167
7802642-2	1994	By primer extension analysis to discriminate two transcripts, we found that the levels of PAFR transcript 1 (leukocyte-type), but not PAFR transcript 2 (tissue-type), are upregulated by PAF as well as by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the human stomach cancer cell line (JR-St cells) which expresses both functional PAFR transcript 1 and PAFR transcript 2 endogenously.	Tetradecanoylphorbol Acetate	204-240	PCNA clamp associated factor	Homo sapiens	90-93
16244358-9	2006	Interestingly, TPA potentiated BPDE-induced activation of ERKs whereas p38 MAPK activation was significantly inhibited by TPA, suggesting that inhibition of p38 MAPK is involved in p53 attenuation by TPA.	Tetradecanoylphorbol Acetate	15-18	transformation related protein 53, pseudogene	Mus musculus	181-184
7802642-2	1994	By primer extension analysis to discriminate two transcripts, we found that the levels of PAFR transcript 1 (leukocyte-type), but not PAFR transcript 2 (tissue-type), are upregulated by PAF as well as by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the human stomach cancer cell line (JR-St cells) which expresses both functional PAFR transcript 1 and PAFR transcript 2 endogenously.	Tetradecanoylphorbol Acetate	242-245	PCNA clamp associated factor	Homo sapiens	90-93
16244358-9	2006	Interestingly, TPA potentiated BPDE-induced activation of ERKs whereas p38 MAPK activation was significantly inhibited by TPA, suggesting that inhibition of p38 MAPK is involved in p53 attenuation by TPA.	Tetradecanoylphorbol Acetate	122-125	transformation related protein 53, pseudogene	Mus musculus	181-184
8293547-6	1994	Mirex plus TPA-promoted papillomas contained a c-Ha-ras A182--&gt;T mutation as frequently (13/14) as those promoted by mirex or TPA alone, suggesting that these DMBA-initiated/co-promoted papillomas were not atypical in this genotypic marker.	Tetradecanoylphorbol Acetate	11-14	POC1 centriolar protein A	Mus musculus	47-51
16244358-9	2006	Interestingly, TPA potentiated BPDE-induced activation of ERKs whereas p38 MAPK activation was significantly inhibited by TPA, suggesting that inhibition of p38 MAPK is involved in p53 attenuation by TPA.	Tetradecanoylphorbol Acetate	122-125	transformation related protein 53, pseudogene	Mus musculus	181-184
7983016-0	1994	Transcription factor egr-1 is involved in phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	42-73	early growth response 1	Homo sapiens	21-26
7983016-3	1994	In this report, we demonstrate that egr-1 mRNA expression, detected by Northern blotting, is activated within 30 min of treatment of the erythroleukemia cell line K562 with phorbol 12-myristate 13-acetate (PMA), and the increased egr-1 mRNA level is associated with an elevated egr-1 antigen expression detected by Western blotting and with its DNA binding activity shown by the gel mobility shift assay.	Tetradecanoylphorbol Acetate	173-204	early growth response 1	Homo sapiens	36-41
7983016-3	1994	In this report, we demonstrate that egr-1 mRNA expression, detected by Northern blotting, is activated within 30 min of treatment of the erythroleukemia cell line K562 with phorbol 12-myristate 13-acetate (PMA), and the increased egr-1 mRNA level is associated with an elevated egr-1 antigen expression detected by Western blotting and with its DNA binding activity shown by the gel mobility shift assay.	Tetradecanoylphorbol Acetate	206-209	early growth response 1	Homo sapiens	36-41
7983016-7	1994	These observations suggest that egr-1 is involved in regulating PMA-induced megakaryocytic differentiation of K562 cell line.	Tetradecanoylphorbol Acetate	64-67	early growth response 1	Homo sapiens	32-37
16510567-7	2006	Proteolytic shedding of both NKG2D ligands MICA and ULBP2 by tumor cells was strongly enhanced after phorbol 12-myristate 13-acetate treatment and paralleled by a markedly reduced susceptibility to NKG2D-mediated cytotoxicity.	Tetradecanoylphorbol Acetate	101-132	UL16 binding protein 2	Homo sapiens	52-57
8001237-4	1994	Fifteen minutes following topical treatment with a tumor promoting dose of TPA (3.4 nmol), the activities of PKC beta and PKC gamma decreased in the epidermal cytosol to 30% and 50% of control values, respectively, while these activities were increased in the epidermal particulate fraction by approximately 50%.	Tetradecanoylphorbol Acetate	75-78	protein kinase C, gamma	Mus musculus	122-131
8001237-7	1994	Immunoblotting analyses of PKC isozyme protein levels after TPA treatment followed the changes in activity for cytosolic PKC alpha, PKC beta and PKC gamma.	Tetradecanoylphorbol Acetate	60-63	protein kinase C, gamma	Mus musculus	145-154
16553792-5	2006	Prior administration of PD98059 also antagonized the enhancing effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator that also causes ERK activation, on SGK phosphorylation and cAMP response element binding protein (CREB) phosphorylation.	Tetradecanoylphorbol Acetate	73-109	cAMP responsive element binding protein 1	Rattus norvegicus	206-243
16553792-5	2006	Prior administration of PD98059 also antagonized the enhancing effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator that also causes ERK activation, on SGK phosphorylation and cAMP response element binding protein (CREB) phosphorylation.	Tetradecanoylphorbol Acetate	73-109	cAMP responsive element binding protein 1	Rattus norvegicus	245-249
7960100-6	1994	Phorbol myristate acetate and 1-oleoyl-2-acetyl-sn-glycerol, activators of protein kinase C, were able to induce pp68 in mouse peritoneal macrophages.	Tetradecanoylphorbol Acetate	0-25	synaptotagmin binding, cytoplasmic RNA interacting protein	Mus musculus	113-117
8167560-7	1994	TOM-1 was also induced to monocytoid lineage by TPA.	Tetradecanoylphorbol Acetate	48-51	target of myb1 membrane trafficking protein	Homo sapiens	0-5
16553792-5	2006	Prior administration of PD98059 also antagonized the enhancing effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator that also causes ERK activation, on SGK phosphorylation and cAMP response element binding protein (CREB) phosphorylation.	Tetradecanoylphorbol Acetate	111-114	cAMP responsive element binding protein 1	Rattus norvegicus	206-243
8264601-6	1994	We have analyzed the activities of the transcription factors TFIIIB and TFIIIC derived from extracts prepared from TPA-induced and noninduced cells.	Tetradecanoylphorbol Acetate	115-118	Brf RNA polymerase III subunit	Drosophila melanogaster	61-67
8264601-8	1994	However, the activity of TFIIIB derived from the TPA-induced cells is substantially increased compared with that derived from the noninduced cells.	Tetradecanoylphorbol Acetate	49-52	Brf RNA polymerase III subunit	Drosophila melanogaster	25-31
16553792-5	2006	Prior administration of PD98059 also antagonized the enhancing effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator that also causes ERK activation, on SGK phosphorylation and cAMP response element binding protein (CREB) phosphorylation.	Tetradecanoylphorbol Acetate	111-114	cAMP responsive element binding protein 1	Rattus norvegicus	245-249
16553792-6	2006	Moreover, TPA-induced SGK phosphorylation and CREB phosphorylation was abolished by prior SGKS78A mutant DNA transfection.	Tetradecanoylphorbol Acetate	10-13	cAMP responsive element binding protein 1	Rattus norvegicus	46-50
7989495-3	1994	By polymerase chain reaction of reverse-transcribed RNA we detected IL-1ra messenger RNA in cultures of all types of pituitary adenomas under basal conditions as well as after stimulation of the cells with endotoxin or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	219-244	interleukin 1 receptor antagonist	Homo sapiens	68-74
16476973-7	2006	Some of the important genes that were overexpressed during the S phase of the cell cycle compared with the G0/1 phase of TPA-induced BCBL-1 cells are v-myb myeloblastosis (MYBL2), protein kinase-membrane associated tyrosine/threonine 1 (PKMYT1), ribonucleotide reductase M1 polypeptide (RRM1) and peroxisome proliferator-activated receptors delta (PPARD).	Tetradecanoylphorbol Acetate	121-124	MYB proto-oncogene like 2	Homo sapiens	172-177
7907511-11	1994	In contrast, in the presence of Ctx, the PKC-activating phorbol ester TPA synergistically stimulated cAMP production, raising cAMP levels as high as isoproterenol-stimulated levels.	Tetradecanoylphorbol Acetate	70-73	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	32-35
16476973-7	2006	Some of the important genes that were overexpressed during the S phase of the cell cycle compared with the G0/1 phase of TPA-induced BCBL-1 cells are v-myb myeloblastosis (MYBL2), protein kinase-membrane associated tyrosine/threonine 1 (PKMYT1), ribonucleotide reductase M1 polypeptide (RRM1) and peroxisome proliferator-activated receptors delta (PPARD).	Tetradecanoylphorbol Acetate	121-124	protein kinase, membrane associated tyrosine/threonine 1	Homo sapiens	180-235
7527831-14	1994	The phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) also stimulated nitric oxide production by macrophages and endothelial cells from endotoxin-treated rats, although not as effectively as LPS and IFN-gamma.	Tetradecanoylphorbol Acetate	57-60	interferon gamma	Rattus norvegicus	207-216
16476973-7	2006	Some of the important genes that were overexpressed during the S phase of the cell cycle compared with the G0/1 phase of TPA-induced BCBL-1 cells are v-myb myeloblastosis (MYBL2), protein kinase-membrane associated tyrosine/threonine 1 (PKMYT1), ribonucleotide reductase M1 polypeptide (RRM1) and peroxisome proliferator-activated receptors delta (PPARD).	Tetradecanoylphorbol Acetate	121-124	protein kinase, membrane associated tyrosine/threonine 1	Homo sapiens	237-243
7841543-6	1994	A time course study showed that both hKLK2 and c-myc mRNAs were repressed by TPA as early as four hours.	Tetradecanoylphorbol Acetate	77-80	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	47-52
7954373-0	1994	Curcumin inhibits TPA induced expression of c-fos, c-jun and c-myc proto-oncogenes messenger RNAs in mouse skin.	Tetradecanoylphorbol Acetate	18-21	FBJ osteosarcoma oncogene	Mus musculus	44-49
16476973-8	2006	Inhibition of PKMYT1 expression by the use of specific short interfering RNAs significantly lowered the TPA-induced KSHV lytic cycle of infection.	Tetradecanoylphorbol Acetate	104-107	protein kinase, membrane associated tyrosine/threonine 1	Homo sapiens	14-20
7954373-7	1994	In the present studies, we investigated the effect of curcumin on the expression of c-fos, c-jun and c-myc oncogenes in TPA-treated mouse skin in CD-1 mice.	Tetradecanoylphorbol Acetate	120-123	FBJ osteosarcoma oncogene	Mus musculus	84-89
8146021-5	1994	Conversely, PMA-induced inhibition of EPO mRNA accumulation was paralleled by translocation of PKC alpha from cytosol to membranes and the time- and dose-dependent attenuation of the inhibitory effect of PMA on EPO mRNA levels was paralleled by down-regulation of PKC alpha.	Tetradecanoylphorbol Acetate	12-15	erythropoietin	Rattus norvegicus	38-41
7954373-8	1994	A 30-nmol dose of TPA increased the levels of mRNAs for c-fos, c-jun and c-myc oncogenes by 2-3-fold compared with control.	Tetradecanoylphorbol Acetate	18-21	FBJ osteosarcoma oncogene	Mus musculus	56-61
7954373-11	1994	A dose of 10 mumol of curcumin was found to inhibit 90% TPA-induced expression of c-fos and c-jun, and 60% of c-myc.	Tetradecanoylphorbol Acetate	56-59	FBJ osteosarcoma oncogene	Mus musculus	82-87
8146021-5	1994	Conversely, PMA-induced inhibition of EPO mRNA accumulation was paralleled by translocation of PKC alpha from cytosol to membranes and the time- and dose-dependent attenuation of the inhibitory effect of PMA on EPO mRNA levels was paralleled by down-regulation of PKC alpha.	Tetradecanoylphorbol Acetate	12-15	erythropoietin	Rattus norvegicus	211-214
8146021-5	1994	Conversely, PMA-induced inhibition of EPO mRNA accumulation was paralleled by translocation of PKC alpha from cytosol to membranes and the time- and dose-dependent attenuation of the inhibitory effect of PMA on EPO mRNA levels was paralleled by down-regulation of PKC alpha.	Tetradecanoylphorbol Acetate	204-207	erythropoietin	Rattus norvegicus	38-41
16478713-3	2006	Under improved selection conditions using a TPA-responsive element (TRE) as a bait DNA, known interactors c-fos and c-jun were simultaneously enriched about 100-fold from a model library (a 1:1:20 000 mixture of c-fos, c-jun and gst genes) after one round of selection.	Tetradecanoylphorbol Acetate	44-47	FBJ osteosarcoma oncogene	Mus musculus	106-111
7930608-8	1994	We also report that PAF enhances PMA-induced TNF-alpha production from human peripheral B cells.	Tetradecanoylphorbol Acetate	33-36	PCNA clamp associated factor	Homo sapiens	20-23
7523141-4	1994	We demonstrate that both the TcR+ and TcR- clones were able to express the Fas ligand after stimulation with phorbol 12-myristate 13-acetate (PMA)/ionomycin, and that TcR engagement of the KB5.C20 clone by means of antigen-bearing cells or of its anticlonotypic mAb (Desire-1), which leads to Ca(2+)-dependent, presumably perforin-based, cytotoxicity, was also able to induce Fas-based cytotoxicity.	Tetradecanoylphorbol Acetate	109-140	T cell receptor alpha variable 12-3	Rattus norvegicus	29-32
7523141-4	1994	We demonstrate that both the TcR+ and TcR- clones were able to express the Fas ligand after stimulation with phorbol 12-myristate 13-acetate (PMA)/ionomycin, and that TcR engagement of the KB5.C20 clone by means of antigen-bearing cells or of its anticlonotypic mAb (Desire-1), which leads to Ca(2+)-dependent, presumably perforin-based, cytotoxicity, was also able to induce Fas-based cytotoxicity.	Tetradecanoylphorbol Acetate	109-140	T cell receptor alpha variable 12-3	Rattus norvegicus	38-41
7523141-4	1994	We demonstrate that both the TcR+ and TcR- clones were able to express the Fas ligand after stimulation with phorbol 12-myristate 13-acetate (PMA)/ionomycin, and that TcR engagement of the KB5.C20 clone by means of antigen-bearing cells or of its anticlonotypic mAb (Desire-1), which leads to Ca(2+)-dependent, presumably perforin-based, cytotoxicity, was also able to induce Fas-based cytotoxicity.	Tetradecanoylphorbol Acetate	109-140	T cell receptor alpha variable 12-3	Rattus norvegicus	38-41
8146021-5	1994	Conversely, PMA-induced inhibition of EPO mRNA accumulation was paralleled by translocation of PKC alpha from cytosol to membranes and the time- and dose-dependent attenuation of the inhibitory effect of PMA on EPO mRNA levels was paralleled by down-regulation of PKC alpha.	Tetradecanoylphorbol Acetate	204-207	erythropoietin	Rattus norvegicus	211-214
16452183-6	2006	On comparison with all previous HK1.ras carcinomas, such TPA-induced carcinomas expressed atypical retention of keratin K1 and lack of K13, a unique marker profile exhibited by TPA-induced K14.cre/PTEN(flx/flx) papillomas that also lacked endogenous c-ras(Ha) activation.	Tetradecanoylphorbol Acetate	57-60	keratin 14	Mus musculus	189-192
8165871-0	1994	EBV-immortalized isogenic human B-cell clones exhibit differences in DNA-protein complex formation on the BZLF1 and BRLF1 promoter regions among latent, lytic and TPA-activated cell lines.	Tetradecanoylphorbol Acetate	163-166	protein Zta	Human gammaherpesvirus 4	106-111
7523141-4	1994	We demonstrate that both the TcR+ and TcR- clones were able to express the Fas ligand after stimulation with phorbol 12-myristate 13-acetate (PMA)/ionomycin, and that TcR engagement of the KB5.C20 clone by means of antigen-bearing cells or of its anticlonotypic mAb (Desire-1), which leads to Ca(2+)-dependent, presumably perforin-based, cytotoxicity, was also able to induce Fas-based cytotoxicity.	Tetradecanoylphorbol Acetate	142-145	T cell receptor alpha variable 12-3	Rattus norvegicus	29-32
7523141-4	1994	We demonstrate that both the TcR+ and TcR- clones were able to express the Fas ligand after stimulation with phorbol 12-myristate 13-acetate (PMA)/ionomycin, and that TcR engagement of the KB5.C20 clone by means of antigen-bearing cells or of its anticlonotypic mAb (Desire-1), which leads to Ca(2+)-dependent, presumably perforin-based, cytotoxicity, was also able to induce Fas-based cytotoxicity.	Tetradecanoylphorbol Acetate	142-145	T cell receptor alpha variable 12-3	Rattus norvegicus	38-41
7523141-4	1994	We demonstrate that both the TcR+ and TcR- clones were able to express the Fas ligand after stimulation with phorbol 12-myristate 13-acetate (PMA)/ionomycin, and that TcR engagement of the KB5.C20 clone by means of antigen-bearing cells or of its anticlonotypic mAb (Desire-1), which leads to Ca(2+)-dependent, presumably perforin-based, cytotoxicity, was also able to induce Fas-based cytotoxicity.	Tetradecanoylphorbol Acetate	142-145	T cell receptor alpha variable 12-3	Rattus norvegicus	38-41
7926375-2	1994	It has been shown in a previous study that TPA induces the expression of the highly inflammatory cytokine, interleukin (IL) -1 alpha, in the epidermis of SENCAR mice.	Tetradecanoylphorbol Acetate	43-46	interleukin 1 alpha	Mus musculus	107-132
7926375-3	1994	The goal of this study was to investigate the role of IL-1 alpha in several TPA-induced responses in skin.	Tetradecanoylphorbol Acetate	76-79	interleukin 1 alpha	Mus musculus	54-64
7926375-4	1994	Topical application of TPA (1 microgram) enhanced the production of immunoreactive IL-1 alpha protein, primarily associated with the suprabasal keratinocytes.	Tetradecanoylphorbol Acetate	23-26	interleukin 1 alpha	Mus musculus	83-93
16452183-6	2006	On comparison with all previous HK1.ras carcinomas, such TPA-induced carcinomas expressed atypical retention of keratin K1 and lack of K13, a unique marker profile exhibited by TPA-induced K14.cre/PTEN(flx/flx) papillomas that also lacked endogenous c-ras(Ha) activation.	Tetradecanoylphorbol Acetate	177-180	keratin 14	Mus musculus	189-192
7926375-6	1994	TPA produced fourfold increases in vascular permeability as measured by Evans blue dye leakage; this effect was prevented by intradermal injection of anti-IL-1 alpha antibody (25-75 micrograms).	Tetradecanoylphorbol Acetate	0-3	interleukin 1 alpha	Mus musculus	155-165
7926375-7	1994	Furthermore, injected anti-IL-1 alpha antibody significantly reduced (P &lt; 0.001) TPA-induced inflammatory cell infiltration and epidermal hyperplasia.	Tetradecanoylphorbol Acetate	84-87	interleukin 1 alpha	Mus musculus	27-37
16452183-9	2006	However, in progression, reduced ras(Ha)-associated ERK protein and activity, increased Delta5PTEN-associated cyclin E2 expression, and unique K1/K13 profiles following TPA treatment suggest that PTEN loss, rather than ras(Ha) activation, gives rise to a population of cells with greater malignant potential.	Tetradecanoylphorbol Acetate	169-172	keratin 1	Mus musculus	143-149
7926375-8	1994	This study suggests that IL-1 alpha directly or indirectly mediates the inflammatory and hyperplastic responses elicited by topical treatment with TPA.	Tetradecanoylphorbol Acetate	147-150	interleukin 1 alpha	Mus musculus	25-35
7506546-8	1993	Short pretreatment with phorbol myristate acetate blunted the SCF-induced AA liberation.	Tetradecanoylphorbol Acetate	24-49	KIT ligand	Rattus norvegicus	62-65
16417239-5	2006	In the analysis of PBMCs in MF, we found that CTLA-4 is stimulated by phorbol myristate acetate/A23187 to a greater level when compared to normals.	Tetradecanoylphorbol Acetate	70-95	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	46-52
8268240-4	1993	Stimulation of porcine neutrophils with either myristic acid or phorbol myristate acetate resulted in great enhancement of the oxidase activity, and in considerable translocation of p49-phox and p63-phox.	Tetradecanoylphorbol Acetate	64-89	tumor protein p63	Homo sapiens	195-198
8268245-2	1993	IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner.	Tetradecanoylphorbol Acetate	39-75	interleukin 1 alpha	Homo sapiens	0-4
8268245-2	1993	IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner.	Tetradecanoylphorbol Acetate	77-80	interleukin 1 alpha	Homo sapiens	0-4
8268245-4	1993	When protein kinase C was down-regulated by treating the cells with a high level of TPA, the inductive effect of IL-1 upon proMMP-3 production was reduced considerably.	Tetradecanoylphorbol Acetate	84-87	interleukin 1 alpha	Homo sapiens	113-117
8280080-6	1993	The expression of MMP-3 and MMP-1 was further enhanced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	58-89	matrix metallopeptidase 1	Homo sapiens	28-33
8280080-6	1993	The expression of MMP-3 and MMP-1 was further enhanced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	91-94	matrix metallopeptidase 1	Homo sapiens	28-33
7927239-7	1994	Phorbol ester PMA (phorbol 12-myristate 13-acetate), a potent activator of protein kinase C, induced a slight intracellular pH increase significantly smaller than that with epidermal growth factor, whereas this effect was completely blocked by pretreatment with H-7, indicating that PMA-induced intracellular pH increase is mediated by protein kinase C pathways, unlike epidermal growth factor.	Tetradecanoylphorbol Acetate	19-50	epidermal growth factor	Homo sapiens	370-393
7927239-7	1994	Phorbol ester PMA (phorbol 12-myristate 13-acetate), a potent activator of protein kinase C, induced a slight intracellular pH increase significantly smaller than that with epidermal growth factor, whereas this effect was completely blocked by pretreatment with H-7, indicating that PMA-induced intracellular pH increase is mediated by protein kinase C pathways, unlike epidermal growth factor.	Tetradecanoylphorbol Acetate	14-17	epidermal growth factor	Homo sapiens	173-196
7927239-7	1994	Phorbol ester PMA (phorbol 12-myristate 13-acetate), a potent activator of protein kinase C, induced a slight intracellular pH increase significantly smaller than that with epidermal growth factor, whereas this effect was completely blocked by pretreatment with H-7, indicating that PMA-induced intracellular pH increase is mediated by protein kinase C pathways, unlike epidermal growth factor.	Tetradecanoylphorbol Acetate	14-17	epidermal growth factor	Homo sapiens	370-393
7523530-6	1994	Upon stimulation with phorbol myristate acetate and A23187, cultured cells showed substantially more release of IL-3 and TNF-alpha after 14 d of culture, compared to peripheral blood monocytic cells.	Tetradecanoylphorbol Acetate	22-47	interleukin 3	Homo sapiens	112-116
16234246-9	2005	Treatment of MDA-MB-231 cells with phorbol 12-myristate 13-acetate induced protein kinase C-dependent phosphorylation of Hsp27 and tumor cell migration.	Tetradecanoylphorbol Acetate	35-66	heat shock protein family B (small) member 1	Homo sapiens	121-126
7931079-8	1994	Mutations of the genuine octamer-binding site abrogate both the binding of Oct-1 and Oct-2 and the TPA/Ca2+-induced transactivation of the OAP/octamer motif.	Tetradecanoylphorbol Acetate	99-102	POU class 2 homeobox 1	Homo sapiens	75-80
7820071-3	1994	The activator of protein kinase C tetradecanoylphorbolacetate (0.001-1 microM) increased the level of proenkephalin-mRNA in a concentration dependent manner.	Tetradecanoylphorbol Acetate	34-61	proenkephalin	Rattus norvegicus	102-115
8280080-13	1993	On the other hand, forskolin suppressed the PMA-mediated induction of MMP-1 and MMP-3 in synovial fibroblasts, while it enhanced or did not affect this induction in various types of human endothelial cells.	Tetradecanoylphorbol Acetate	44-47	matrix metallopeptidase 1	Homo sapiens	70-75
16234246-10	2005	In contrast, treatment of MDA-MB-231 cells with KRIBB3 blocked phorbol 12-myristate 13-acetate-induced phosphorylation of Hsp27 and tumor cell migration.	Tetradecanoylphorbol Acetate	63-94	heat shock protein family B (small) member 1	Homo sapiens	122-127
8262378-5	1993	We have used this procedure to examine the differential binding of nuclear factors from the U937 monocytic cell in the absence and in the presence of the differentiating agent, 12-phorbol 13-myristate acetate (PMA), in order to identify proteins that bind specifically to the 5" flanking promoter region and first intron of PAI-2.	Tetradecanoylphorbol Acetate	210-213	serpin family B member 2	Homo sapiens	324-329
16351709-7	2005	Furthermore, the TPA-mediated post-transcriptional mechanism of p21WAF1-enhanced expression in RD cells is due to activation of the MEK/ERK pathway, as shown by transfections with constitutively active MEK1 or MEK2, which induces p21WAF1 expression, and with ERK1 and ERK2 siRNA, which prevents p21WAF1 expression.	Tetradecanoylphorbol Acetate	17-20	mitogen-activated protein kinase kinase 1	Homo sapiens	202-206
7929035-1	1994	In vitro decay of granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA was examined on polysomes prepared from normal human peripheral blood mononuclear cells stimulated with phorbol ester (TPA) and phytohemagglutinin for 14 h. GM-CSF mRNA decayed with a half-life of 90 min while 18 S rRNA was stable.	Tetradecanoylphorbol Acetate	200-203	colony stimulating factor 2	Homo sapiens	68-74
16293250-2	2005	Costimulation of Jurkat cells with 12-O-tetradecanoylphorbol-13-acetate and A23187 leads to a rapid phosphorylation of TAK1 and TAK1-binding protein 1 (TAB1), critical for TAK1 activation.	Tetradecanoylphorbol Acetate	35-71	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	119-123
7929090-6	1994	The phosphotyrosine content of p125FAK, paxillin, and p130 was also increased following stimulation with phorbol 12-myristate 13-acetate (PMA) (0.1 microM).	Tetradecanoylphorbol Acetate	138-141	PTK2 protein tyrosine kinase 2	Mus musculus	31-38
7937106-8	1994	Consistent with the in vitro results, point mutations in p68c-ets-1 that decrease binding activity to EBS abrogate its ability to transactivate reporter plasmids carrying either the TPA Oncogene Response Unit of the Polyoma virus enhancer (TORU) or a sequence derived from the HTLV-1 LTR.	Tetradecanoylphorbol Acetate	182-185	ETS proto-oncogene 1, transcription factor	Homo sapiens	62-67
16293250-2	2005	Costimulation of Jurkat cells with 12-O-tetradecanoylphorbol-13-acetate and A23187 leads to a rapid phosphorylation of TAK1 and TAK1-binding protein 1 (TAB1), critical for TAK1 activation.	Tetradecanoylphorbol Acetate	35-71	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	128-132
16054658-8	2005	Upon stimulation by phorbol 12-myristate 13-acetate (PMA), Trx translocates into cell nuclei.	Tetradecanoylphorbol Acetate	20-51	thioredoxin	Homo sapiens	59-62
8073291-8	1994	Stimulation of synthesis of cyclic adenosine 3",5"-monophosphate abolished activation of MEKK and B-Raf by EGF, NGF, and TPA.	Tetradecanoylphorbol Acetate	121-124	B-Raf proto-oncogene, serine/threonine kinase	Rattus norvegicus	98-103
16054658-8	2005	Upon stimulation by phorbol 12-myristate 13-acetate (PMA), Trx translocates into cell nuclei.	Tetradecanoylphorbol Acetate	53-56	thioredoxin	Homo sapiens	59-62
7943258-6	1994	Treatment with phorbol 12-myristate 13-acetate (PMA, 1 microM for 15 min), an activator of PKC, decreased NO2- similarly to TNF.	Tetradecanoylphorbol Acetate	15-46	tumor necrosis factor	Bos taurus	124-127
16172133-4	2005	Ex vivo stimulation of DP thymocytes with phorbol myristate acetate or antibodies that activate the TCR complex led to the accumulation of DRAK2 in a protein kinase C- and MAP Kinase-dependent fashion.	Tetradecanoylphorbol Acetate	42-67	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	100-103
7943258-6	1994	Treatment with phorbol 12-myristate 13-acetate (PMA, 1 microM for 15 min), an activator of PKC, decreased NO2- similarly to TNF.	Tetradecanoylphorbol Acetate	48-51	tumor necrosis factor	Bos taurus	124-127
7847852-7	1994	Flow immunocytometry revealed reduced levels of c-myc and bcl-2 oncoproteins in RA and PMA treated cells.	Tetradecanoylphorbol Acetate	87-90	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	48-53
8083366-8	1994	Activation of T lymphocytes with PMA stimulated binding to platelets that was Mg2+ dependent and could be specifically inhibited by mAbs to either ICAM-2 or leukocyte function-associated antigen-1.	Tetradecanoylphorbol Acetate	33-36	intercellular adhesion molecule 2	Homo sapiens	147-153
8083760-6	1994	Treatment with either TGF alpha or its structural homolog, epidermal growth factor (EGF), increased TGF alpha mRNA levels within 8 hr of exposure; the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was similarly effective.	Tetradecanoylphorbol Acetate	165-202	epidermal growth factor	Homo sapiens	59-82
8083760-6	1994	Treatment with either TGF alpha or its structural homolog, epidermal growth factor (EGF), increased TGF alpha mRNA levels within 8 hr of exposure; the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was similarly effective.	Tetradecanoylphorbol Acetate	165-202	epidermal growth factor	Homo sapiens	84-87
8083760-6	1994	Treatment with either TGF alpha or its structural homolog, epidermal growth factor (EGF), increased TGF alpha mRNA levels within 8 hr of exposure; the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was similarly effective.	Tetradecanoylphorbol Acetate	204-207	epidermal growth factor	Homo sapiens	59-82
8083760-6	1994	Treatment with either TGF alpha or its structural homolog, epidermal growth factor (EGF), increased TGF alpha mRNA levels within 8 hr of exposure; the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was similarly effective.	Tetradecanoylphorbol Acetate	204-207	epidermal growth factor	Homo sapiens	84-87
7519845-3	1994	Moreover, DEM abolished phorbol 12-myristate 13-acetate-induced activation of the transcription factors AP-1 and Egr-1, suggesting that inhibition of differentiation may be due, at least in part, to redox modifications of these proteins.	Tetradecanoylphorbol Acetate	24-55	early growth response 1	Homo sapiens	113-118
8045498-5	1994	Interleukin-1 beta and phorbol myristate acetate were also shown to induce in a dose-dependent fashion a threefold to fivefold increase of interleukin-6 production as measured by enzyme-linked immunosorbent assay in human primary biliary duct epithelium cultures, when compared with hepatocyte growth factor, epidermal growth factor, insulin-like growth factor, phytohemagglutinin, tumor necrosis factor-alpha or platelet-derived growth factor.	Tetradecanoylphorbol Acetate	23-48	epidermal growth factor	Homo sapiens	309-332
8045973-6	1994	Northern analysis demonstrated specific messenger ribonucleic acid for pro-MMP-1 and pro-MMP-3 in phorbol myristate acetate-stimulated stromal cells.	Tetradecanoylphorbol Acetate	98-123	matrix metallopeptidase 1	Homo sapiens	75-80
7913952-4	1994	We describe gp34 as a new member of the TNF family, and find that the recombinant ligand expressed in COS cells costimulates phorbol myristate acetate, phytohemagglutinin, and anti-CD3-induced CD4+ T cell proliferation.	Tetradecanoylphorbol Acetate	125-150	TNF superfamily member 4	Homo sapiens	12-16
8035813-3	1994	NF-kappa B p50/p65 is the major inducible nuclear complex after lipopolysaccharide or phorbol myristate acetate treatment of 70Z/3 cells.	Tetradecanoylphorbol Acetate	86-111	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	15-18
7519010-5	1994	Phorbol 12-myristate 13-acetate, alone or in combination with the calcium ionophore A23187, also stimulated the phosphorylation of pp125fak but to a smaller extent than LPA or ET-1.	Tetradecanoylphorbol Acetate	0-31	protein tyrosine kinase 2	Rattus norvegicus	131-139
7957639-4	1994	The c-fos induction in m3 cells was inhibited by BAPTA-AM and prolonged treatment with TPA, but was not influenced by W-7, suggesting that protein kinase C is mainly involved in m3-induced c-fos expression.	Tetradecanoylphorbol Acetate	87-90	FBJ osteosarcoma oncogene	Mus musculus	4-9
7517419-0	1994	TNF-alpha associated with fibronectin enhances phorbol myristate acetate- or antigen-mediated integrin-dependent adhesion of CD4+ T cells via protein tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	47-72	fibronectin 1	Rattus norvegicus	26-37
7517419-8	1994	Soluble, and to a greater extent FN-bound, TNF-alpha synergizes with PMA to intensify protein tyrosine phosphorylation in FN-bound CD4+ cells, and this effect of TNF-alpha was inhibited by inhibitors of tyrosine kinase.	Tetradecanoylphorbol Acetate	69-72	fibronectin 1	Rattus norvegicus	122-124
7912755-10	1994	Culture supernatants from blasts cultured with or without TPA showed the production of large amounts of IL-8, IL-6, TNF-alpha, MIP-1 alpha, IL-10 and interferon gamma and modest amounts of IL-1 alpha, GM-CSF and stem cell factor.	Tetradecanoylphorbol Acetate	58-61	C-C motif chemokine ligand 3	Homo sapiens	127-138
7912755-10	1994	Culture supernatants from blasts cultured with or without TPA showed the production of large amounts of IL-8, IL-6, TNF-alpha, MIP-1 alpha, IL-10 and interferon gamma and modest amounts of IL-1 alpha, GM-CSF and stem cell factor.	Tetradecanoylphorbol Acetate	58-61	interleukin 1 alpha	Homo sapiens	189-199
7912755-10	1994	Culture supernatants from blasts cultured with or without TPA showed the production of large amounts of IL-8, IL-6, TNF-alpha, MIP-1 alpha, IL-10 and interferon gamma and modest amounts of IL-1 alpha, GM-CSF and stem cell factor.	Tetradecanoylphorbol Acetate	58-61	colony stimulating factor 2	Homo sapiens	201-207
8010954-9	1994	Northern-blot analysis reveals that steady-state levels of the chicken progelatinase mRNA are increased 5-fold upon malignant transformation of chicken embryo fibroblasts with Rous sarcoma virus (RSV) and 3-fold by treatment with the tumour-promoting phorbol ester, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	266-297	matrix metallopeptidase 3	Mus musculus	71-84
8010954-9	1994	Northern-blot analysis reveals that steady-state levels of the chicken progelatinase mRNA are increased 5-fold upon malignant transformation of chicken embryo fibroblasts with Rous sarcoma virus (RSV) and 3-fold by treatment with the tumour-promoting phorbol ester, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	299-302	matrix metallopeptidase 3	Mus musculus	71-84
8195229-2	1994	Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	290-326	RAF proto-oncogene serine/threonine-protein kinase	Cricetulus griseus	54-59
8195229-2	1994	Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	290-326	WNK lysine deficient protein kinase 2	Homo sapiens	138-144
8195229-2	1994	Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	328-331	RAF proto-oncogene serine/threonine-protein kinase	Cricetulus griseus	54-59
8195229-2	1994	Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	328-331	WNK lysine deficient protein kinase 2	Homo sapiens	138-144
8195229-5	1994	These results suggest that 1) signals initiated by insulin and TPA converge on Raf-1 and activate its MAPKKK activity and 2) Raf-1, MAPKK, and mSos not only lie upstream of MAPK but also are phosphorylated by MAPK, directly or indirectly, and at least Raf-1 kinase activity might be down-regulated by this feedback mechanism.	Tetradecanoylphorbol Acetate	63-66	WNK lysine deficient protein kinase 2	Homo sapiens	102-108
7903912-3	1993	Phorbol-myristate acetate (&gt; 10(-9) M) increased adhesion in both normal and LPS-treated neutrophils, but low doses of this stimulant did not inhibit adhesion.	Tetradecanoylphorbol Acetate	0-25	interferon regulatory factor 6	Homo sapiens	80-83
7925494-4	1993	We now report that gap junctions between C9 cells contain at least two junctional proteins, connexin26 (Cx26) and connexin43 (Cx43), and that the TPA-induced changes in IGJC correlate temporally to changes in the state of phosphorylation of Cx43.	Tetradecanoylphorbol Acetate	146-149	gap junction protein, beta 2	Rattus norvegicus	92-102
7925494-4	1993	We now report that gap junctions between C9 cells contain at least two junctional proteins, connexin26 (Cx26) and connexin43 (Cx43), and that the TPA-induced changes in IGJC correlate temporally to changes in the state of phosphorylation of Cx43.	Tetradecanoylphorbol Acetate	146-149	gap junction protein, beta 2	Rattus norvegicus	104-108
8300159-5	1993	However, pretreatment with the phorbol ester TPA, which directly activates protein kinase C (PKC), caused a marked increase in mediator release and InsP3 production in the CD45-deficient variant compared to the parental RBL-2H3 cells.	Tetradecanoylphorbol Acetate	45-48	protein tyrosine phosphatase, receptor type, C	Rattus norvegicus	172-176
16044159-2	2005	We show that, upon DMBA/TPA-induced skin carcinogenesis, transgenic mice overexpressing ped/pea-15 (Tg(ped/pea-15)) display early development of papillomas and a four-fold increase in papilloma number compared to the nontransgenic littermates (P&lt;0.001).	Tetradecanoylphorbol Acetate	24-27	proliferation and apoptosis adaptor protein 15A	Mus musculus	92-98
16044159-4	2005	The isolated application of TPA, but not that of DMBA, was sufficient to reversibly upregulate ped/pea-15 in both untransformed skin and cultured keratinocytes.	Tetradecanoylphorbol Acetate	28-31	proliferation and apoptosis adaptor protein 15A	Mus musculus	99-105
16044159-5	2005	ped/pea-15 protein levels were also increased in DMBA/TPA-induced papillomas of both Tg(ped/pea-15) and control mice.	Tetradecanoylphorbol Acetate	54-57	proliferation and apoptosis adaptor protein 15A	Mus musculus	4-10
8246960-1	1993	Expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene in T cells is activated by the combination of phorbol ester (phorbol myristate acetate) and calcium ionophore (A23187), which mimic antigen stimulation through the T-cell receptor.	Tetradecanoylphorbol Acetate	142-167	colony stimulating factor 2	Homo sapiens	18-66
16044159-7	2005	The induction of both Caspase-3 and apoptosis by TPA were four-fold inhibited in the skin of the Tg(ped/pea-15) compared to the nontransgenic mice, accompanied by a similarly sized reduction in TPA-induced JNK and p38 stimulation and by constitutive induction of cytoplasmic ERK activity in the transgenics.	Tetradecanoylphorbol Acetate	49-52	proliferation and apoptosis adaptor protein 15A	Mus musculus	104-110
8246960-1	1993	Expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene in T cells is activated by the combination of phorbol ester (phorbol myristate acetate) and calcium ionophore (A23187), which mimic antigen stimulation through the T-cell receptor.	Tetradecanoylphorbol Acetate	142-167	colony stimulating factor 2	Homo sapiens	68-74
16044159-8	2005	ped/pea-15 expression was stably increased in cell lines from DMBA/TPA-induced skin papillomas and carcinomas, paralleled by protection from TPA apoptosis.	Tetradecanoylphorbol Acetate	67-70	proliferation and apoptosis adaptor protein 15A	Mus musculus	4-10
16044159-8	2005	ped/pea-15 expression was stably increased in cell lines from DMBA/TPA-induced skin papillomas and carcinomas, paralleled by protection from TPA apoptosis.	Tetradecanoylphorbol Acetate	141-144	proliferation and apoptosis adaptor protein 15A	Mus musculus	4-10
16044159-9	2005	In the A5 spindle carcinoma cell line, antisense inhibition of ped/pea-15 expression simultaneously rescued sensitivity to TPA-induced Caspase-3 function and apoptosis.	Tetradecanoylphorbol Acetate	123-126	proliferation and apoptosis adaptor protein 15A	Mus musculus	67-73
7510425-4	1993	The PKC agonists phorbol 12-myristate 13-acetate (PMA) and phorbol 12, 13 dibutyrate (PdBu) were both potent inducers of TF in human monocytes, whereas 4 alpha-12, 13 didecanoate (4 alpha-Pdd) had no such effect.	Tetradecanoylphorbol Acetate	17-48	coagulation factor III, tissue factor	Homo sapiens	121-123
15976391-0	2005	Zinc finger transcription factor Egr-1 is involved in stimulation of NHE2 gene expression by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	93-124	early growth response 1	Homo sapiens	33-38
7510425-4	1993	The PKC agonists phorbol 12-myristate 13-acetate (PMA) and phorbol 12, 13 dibutyrate (PdBu) were both potent inducers of TF in human monocytes, whereas 4 alpha-12, 13 didecanoate (4 alpha-Pdd) had no such effect.	Tetradecanoylphorbol Acetate	50-53	coagulation factor III, tissue factor	Homo sapiens	121-123
7510425-5	1993	Both LPS- and PMA-induced TF activity were inhibited, in a concentration dependent manner, by three different PKC inhibitors: H7, staurosporine and calphostin C.	Tetradecanoylphorbol Acetate	14-17	coagulation factor III, tissue factor	Homo sapiens	26-28
15976015-1	2005	Treatment of cultured PANC-1, MIA PaCa-2, and BxPC-3 human pancreatic adenocarcinoma cells with 0.1 to 1.6 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) for 96 h inhibited the proliferation of these cells in a dose-dependent manner, and PANC-1 and MIA PaCa-2 cells were more sensitive to TPA than BxPC-3 cells.	Tetradecanoylphorbol Acetate	110-146	pancreas protein 1	Mus musculus	22-28
8219227-3	1993	In this report, we show that a consensus AP-1 element and a consensus cAMP response element (CRE) located 5" to the CSP-B transcriptional start site are both required for transcriptional activation of the CPS-B promoter in TPA + bt2cAMP-stimulated PEER cells.	Tetradecanoylphorbol Acetate	223-226	granzyme B	Homo sapiens	116-121
15976015-1	2005	Treatment of cultured PANC-1, MIA PaCa-2, and BxPC-3 human pancreatic adenocarcinoma cells with 0.1 to 1.6 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) for 96 h inhibited the proliferation of these cells in a dose-dependent manner, and PANC-1 and MIA PaCa-2 cells were more sensitive to TPA than BxPC-3 cells.	Tetradecanoylphorbol Acetate	110-146	pancreas protein 1	Mus musculus	237-243
8223435-6	1993	Also TPA-induced, p21ras-independent, activation of raf-1 kinase and ERK2 is inhibited by cAMP.	Tetradecanoylphorbol Acetate	5-8	HRas proto-oncogene, GTPase	Rattus norvegicus	18-24
15976015-2	2005	Inhibition of proliferation by TPA in PANC-1 cells was associated with an increase in the level of p21, but this was not observed in MIA PaCa-2 or BxPC-3 cells.	Tetradecanoylphorbol Acetate	31-34	pancreas protein 1	Mus musculus	38-44
16093730-1	2005	The aim of this study was to investigate the role of blood cells in the expression of tissue factor (TF) and P-selectin in platelets and microparticles from blood stimulated with lipopolysaccharide (LPS), with or without the further addition of phorbol myristyl acetate (PMA).	Tetradecanoylphorbol Acetate	271-274	coagulation factor III, tissue factor	Homo sapiens	86-99
8404662-5	1993	H-7 (1.0-60 microM) inhibited LH-, phorbol 12-myristate 13-acetate-, or phorbol 12,13-dibutyrate-stimulated tPA activity dose dependently, and each ID50 was approximately 8 microM.	Tetradecanoylphorbol Acetate	35-66	plasminogen activator, tissue type	Rattus norvegicus	108-111
7903158-8	1993	Stimulation with anti-CD28 mAb in conjunction with phorbol myristate acetate and ionomycin promotes cell cycling in the CD2- subset of CD4-CD8- T cells, and results in a slight induction of CD2 levels during the course of the culture period.	Tetradecanoylphorbol Acetate	51-76	CD28 antigen	Mus musculus	22-26
16093730-1	2005	The aim of this study was to investigate the role of blood cells in the expression of tissue factor (TF) and P-selectin in platelets and microparticles from blood stimulated with lipopolysaccharide (LPS), with or without the further addition of phorbol myristyl acetate (PMA).	Tetradecanoylphorbol Acetate	271-274	coagulation factor III, tissue factor	Homo sapiens	101-103
21573453-5	1993	Induction of proliferin by the tumour promoters butylated hydroxytoluene or TPA was efficiently inhibited at certain concentrations of catalase and superoxide dismutase, but retinoic acid had no effect.	Tetradecanoylphorbol Acetate	76-79	prolactin family 2, subfamily c, member 2	Mus musculus	13-23
16093730-2	2005	TF activity was found to be associated with platelets after 2 h incubation of whole blood with LPS or LPS + PMA, while no TF activity was detected in microparticles from blood subjected to such stimulation.	Tetradecanoylphorbol Acetate	108-111	coagulation factor III, tissue factor	Homo sapiens	0-2
16077980-0	2005	Transcriptional repression of vimentin gene expression by pyrroline dithiocarbamate during 12-O-tetradecanoylphorbol-13-acetate-dependent differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	91-127	vimentin	Homo sapiens	30-38
16077980-2	2005	To gain insight into the role of NF-kappaB in the regulation of the vimentin gene during 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent differentiation of HL-60 cells, the effect of pyrrolidine dithiocarbamete (PDTC) has been investigated using Northern blot hybridization and DNA mobility shift assay.	Tetradecanoylphorbol Acetate	89-125	vimentin	Homo sapiens	68-76
16077980-2	2005	To gain insight into the role of NF-kappaB in the regulation of the vimentin gene during 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent differentiation of HL-60 cells, the effect of pyrrolidine dithiocarbamete (PDTC) has been investigated using Northern blot hybridization and DNA mobility shift assay.	Tetradecanoylphorbol Acetate	127-130	vimentin	Homo sapiens	68-76
8409414-13	1993	Finally, under conditions in which the PKC inhibitor calphostin C blocks PMA-induced p21ras activation, it does not inhibit Ag-induced p21ras activation.	Tetradecanoylphorbol Acetate	73-76	H3 histone pseudogene 16	Homo sapiens	85-88
7517633-6	1994	The phorbol ester, phorbol 12-myristate 13-acetate, also stimulated 36Cl efflux from CFTR oocytes.	Tetradecanoylphorbol Acetate	19-50	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	85-89
16077980-4	2005	TPA-dependent increase of vimentin mRNA level was decreased in a time- and dose-dependent manner by pretreatment with PDTC.	Tetradecanoylphorbol Acetate	0-3	vimentin	Homo sapiens	26-34
16077980-7	2005	Taken together, these results suggest that NF-kappaB may be an essential transacting factor for transcriptional repression of the vimentin gene by PDTC during TPA-dependent differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	159-162	vimentin	Homo sapiens	130-138
16009563-6	2005	GM-CSF primed (4 days) microglia also produced significantly higher amounts of superoxide after PMA-stimulation.	Tetradecanoylphorbol Acetate	96-99	colony stimulating factor 2	Homo sapiens	0-6
8070680-8	1994	Simultaneous addition of 10 eta M PMA and 50 microM H2O2 decreased the oxidant-stimulated phosphorylation of the most acidic HSP27 isoform.	Tetradecanoylphorbol Acetate	34-37	heat shock protein family B (small) member 1	Homo sapiens	125-130
8231250-5	1993	In contrast, c-myc expression decreased when cells underwent terminal differentiation, either along the myelomonocytic (by 12-O-tetradecanoylphorbol-13-acetate) or erythroid (by 1-beta-D-arabinofuranosylcytosine) lineages.	Tetradecanoylphorbol Acetate	123-159	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	13-18
8415766-2	1993	We have identified two DNA segments that are necessary for full phorbol 12-myristate 13-acetate (PMA)-induced activity of the IL-4 promoter region in the thymoma cell line EL4.	Tetradecanoylphorbol Acetate	64-95	interleukin 4	Mus musculus	126-130
8415766-2	1993	We have identified two DNA segments that are necessary for full phorbol 12-myristate 13-acetate (PMA)-induced activity of the IL-4 promoter region in the thymoma cell line EL4.	Tetradecanoylphorbol Acetate	97-100	interleukin 4	Mus musculus	126-130
7523206-3	1994	Prolonged treatment with forskolin (10 microM), ionomycin (1 microM) and PMA (10 nM) for 12 or 24 h resulted in significant decreases in GnRH mRNA levels.	Tetradecanoylphorbol Acetate	73-76	gonadotropin releasing hormone 1	Mus musculus	137-141
16103087-8	2005	The induction levels of epidermal growth factor (EGF) receptor ligands, tumor growth factor alpha (TGF-alpha), and heparin-binding EGF-like growth factor, in the skin of mutant mice by TPA treatment were significantly lower than those in the skin of wild-type mice.	Tetradecanoylphorbol Acetate	185-188	transforming growth factor alpha	Mus musculus	99-108
7523206-4	1994	Time-course studies showed that the increases in GnRH secretion stimulated by forskolin, ionomycin and PMA were gradually attenuated over time in parallel with the decreases in mRNA expression.	Tetradecanoylphorbol Acetate	103-106	gonadotropin releasing hormone 1	Mus musculus	49-53
8172857-4	1994	In this study we examined the signaling pathways and cis-acting regulatory elements required for induction of TF gene expression in HeLa cells in response to serum and the tumor promoter, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	188-219	coagulation factor III, tissue factor	Homo sapiens	110-112
8104537-10	1993	On preactivating the same cells, using phorbol myristate acetate (PMA)/ionomycin on concanavalin A (ConA) or especially PHA, levels of CD26 were upregulated and the immunotoxin effectively inhibited the ability to provide help for B-cell Ig synthesis while leaving intact the CD4-CD26+ and CD4+CD26- populations; an effect observed both functionally and by phenotype.	Tetradecanoylphorbol Acetate	39-64	dipeptidyl peptidase 4	Homo sapiens	280-284
8104537-10	1993	On preactivating the same cells, using phorbol myristate acetate (PMA)/ionomycin on concanavalin A (ConA) or especially PHA, levels of CD26 were upregulated and the immunotoxin effectively inhibited the ability to provide help for B-cell Ig synthesis while leaving intact the CD4-CD26+ and CD4+CD26- populations; an effect observed both functionally and by phenotype.	Tetradecanoylphorbol Acetate	39-64	dipeptidyl peptidase 4	Homo sapiens	280-284
8104537-10	1993	On preactivating the same cells, using phorbol myristate acetate (PMA)/ionomycin on concanavalin A (ConA) or especially PHA, levels of CD26 were upregulated and the immunotoxin effectively inhibited the ability to provide help for B-cell Ig synthesis while leaving intact the CD4-CD26+ and CD4+CD26- populations; an effect observed both functionally and by phenotype.	Tetradecanoylphorbol Acetate	66-69	dipeptidyl peptidase 4	Homo sapiens	135-139
8104537-10	1993	On preactivating the same cells, using phorbol myristate acetate (PMA)/ionomycin on concanavalin A (ConA) or especially PHA, levels of CD26 were upregulated and the immunotoxin effectively inhibited the ability to provide help for B-cell Ig synthesis while leaving intact the CD4-CD26+ and CD4+CD26- populations; an effect observed both functionally and by phenotype.	Tetradecanoylphorbol Acetate	66-69	dipeptidyl peptidase 4	Homo sapiens	280-284
8104537-10	1993	On preactivating the same cells, using phorbol myristate acetate (PMA)/ionomycin on concanavalin A (ConA) or especially PHA, levels of CD26 were upregulated and the immunotoxin effectively inhibited the ability to provide help for B-cell Ig synthesis while leaving intact the CD4-CD26+ and CD4+CD26- populations; an effect observed both functionally and by phenotype.	Tetradecanoylphorbol Acetate	66-69	dipeptidyl peptidase 4	Homo sapiens	280-284
8172857-4	1994	In this study we examined the signaling pathways and cis-acting regulatory elements required for induction of TF gene expression in HeLa cells in response to serum and the tumor promoter, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	221-224	coagulation factor III, tissue factor	Homo sapiens	110-112
7914436-4	1994	The protein kinase C (PKC) activator phorbol myristate acetate (PMA) triggered both IL-3 and IL-5 mRNA expression, whereby IL-5 and IL-3 mRNA expression was observed after 9 and 3 h treatment, respectively.	Tetradecanoylphorbol Acetate	37-62	interleukin 3	Homo sapiens	84-88
16103087-8	2005	The induction levels of epidermal growth factor (EGF) receptor ligands, tumor growth factor alpha (TGF-alpha), and heparin-binding EGF-like growth factor, in the skin of mutant mice by TPA treatment were significantly lower than those in the skin of wild-type mice.	Tetradecanoylphorbol Acetate	185-188	heparin-binding EGF-like growth factor	Mus musculus	115-153
7914436-4	1994	The protein kinase C (PKC) activator phorbol myristate acetate (PMA) triggered both IL-3 and IL-5 mRNA expression, whereby IL-5 and IL-3 mRNA expression was observed after 9 and 3 h treatment, respectively.	Tetradecanoylphorbol Acetate	37-62	interleukin 3	Homo sapiens	132-136
7914436-4	1994	The protein kinase C (PKC) activator phorbol myristate acetate (PMA) triggered both IL-3 and IL-5 mRNA expression, whereby IL-5 and IL-3 mRNA expression was observed after 9 and 3 h treatment, respectively.	Tetradecanoylphorbol Acetate	64-67	interleukin 3	Homo sapiens	84-88
7914436-4	1994	The protein kinase C (PKC) activator phorbol myristate acetate (PMA) triggered both IL-3 and IL-5 mRNA expression, whereby IL-5 and IL-3 mRNA expression was observed after 9 and 3 h treatment, respectively.	Tetradecanoylphorbol Acetate	64-67	interleukin 3	Homo sapiens	132-136
8402933-0	1993	Induction of CD45 isoform switch in murine B cells by antigen receptor stimulation and by phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	90-115	protein tyrosine phosphatase, receptor type, C	Mus musculus	13-17
8402933-4	1993	Phorbol myristate acetate (PMA) alone did not significantly alter the expression of CD45 but the combination of PMA and ionomycin induced a strong reduction in the expression of CD45RA-, B-, and C-exon-dependent epitopes without affecting the level of CD45 common epitope expression.	Tetradecanoylphorbol Acetate	0-25	protein tyrosine phosphatase, receptor type, C	Mus musculus	178-182
16075364-9	2005	Selective activation of cAMP-PKA signaling with, 10 microM forskolin (FSK) and PKC signaling with 1 microM phorbol 12-myristate 13-acetate (PMA) significantly increased RAMP3 mRNA levels, whereas 1 microM ionomycin (a calcium ionophore) had no effect.	Tetradecanoylphorbol Acetate	107-138	receptor (calcitonin) activity modifying protein 3	Mus musculus	169-174
7512497-7	1994	The protein kinase-C activator 12-O-tetradecanoyl phorbol-13-acetate and cytokines, tumor necrosis factor-alpha and interferon-gamma, inhibited H19 and IGF-II RNA accumulation.	Tetradecanoylphorbol Acetate	31-68	H19 imprinted maternally expressed transcript	Homo sapiens	144-147
7512497-7	1994	The protein kinase-C activator 12-O-tetradecanoyl phorbol-13-acetate and cytokines, tumor necrosis factor-alpha and interferon-gamma, inhibited H19 and IGF-II RNA accumulation.	Tetradecanoylphorbol Acetate	31-68	insulin like growth factor 2	Homo sapiens	152-158
16075364-9	2005	Selective activation of cAMP-PKA signaling with, 10 microM forskolin (FSK) and PKC signaling with 1 microM phorbol 12-myristate 13-acetate (PMA) significantly increased RAMP3 mRNA levels, whereas 1 microM ionomycin (a calcium ionophore) had no effect.	Tetradecanoylphorbol Acetate	140-143	receptor (calcitonin) activity modifying protein 3	Mus musculus	169-174
8404615-4	1993	However, RA potentiated PMA-mediated induction of PAI-2 mRNA in HL-60 and U937 cells and PAI-2 antigen in all four cell lines.	Tetradecanoylphorbol Acetate	24-27	serpin family B member 2	Homo sapiens	50-55
16294063-8	2005	RESULTS: The combination of PTX with HS10 and with HS40 markedly decreased LPS- (27 +/- 7 and 23 +/- 6 vs. 100; p &lt; 0.01), f-methionyl-leucyl-phenylalanine- (54 +/- 11 and 55 +/- 8 vs. 100; p &lt; 0.05), and phorbol 12-myristate 13-acetate- (30 +/- 4 and 54 +/- 9 vs. 100; p &lt; 0.01 and p &lt; 0.05, respectively) induced PMN oxidative burst.	Tetradecanoylphorbol Acetate	211-242	NPR3 like, GATOR1 complex subunit	Homo sapiens	51-55
8223568-5	1993	The noradrenaline- or PGF2 alpha-elicited activation of glycogen phosphorylase and increase in InsP3 were largely reduced after preincubation of the cells for 10 min with PMA, whereas the glucagon-mediated enzyme activation was not affected.	Tetradecanoylphorbol Acetate	171-174	glycogen phosphorylase L	Rattus norvegicus	56-78
7903276-4	1993	In the presence of phorbol myristate acetate (PMA), large amounts of IL-2 were induced by both anti-CD3 and anti-CD2 stimulation, which was accompanied by strong concurrent tyrosine phosphorylation of the 42,000 MW ERK and a 100,000 MW protein.	Tetradecanoylphorbol Acetate	19-44	CD2 molecule	Homo sapiens	113-116
7903276-4	1993	In the presence of phorbol myristate acetate (PMA), large amounts of IL-2 were induced by both anti-CD3 and anti-CD2 stimulation, which was accompanied by strong concurrent tyrosine phosphorylation of the 42,000 MW ERK and a 100,000 MW protein.	Tetradecanoylphorbol Acetate	46-49	CD2 molecule	Homo sapiens	113-116
8188084-2	1994	EGF (10 ng/ml) and the tumor promoter, protein kinase C agonist, phorbol 12-myristate 13-acetate (PMA) were potent stimulators (P &lt; 0.01) of DNA synthesis in this cell line as determined by [3H]thymidine incorporation into DNA.	Tetradecanoylphorbol Acetate	98-101	epidermal growth factor	Homo sapiens	0-3
8058205-7	1994	The molecular basis of the inhibitory effect of TPA was further examined using Xenopus oocytes expressing GAT1, a beta-alanine-insensitive and nipecotate-sensitive neuronal GABA transporter, resulting in a similar effect of TPA.	Tetradecanoylphorbol Acetate	48-51	solute carrier family 6 (neurotransmitter transporter), member 1 S homeolog	Xenopus laevis	106-110
16114500-5	2005	SAG inhibited dose-dependently edematic response of arachidonic acid (AA)- and 12-O-tetradecanoyl 13-acetate (TPA)-induced ear edema in mice, which is an animal model of acute inflammation.	Tetradecanoylphorbol Acetate	110-113	S-antigen, retina and pineal gland (arrestin)	Mus musculus	0-3
8178955-0	1994	Effects of CGRP, forskolin, PMA, and ionomycin on pHi dependence of Na-H exchange in UMR-106 cells.	Tetradecanoylphorbol Acetate	28-31	glucose-6-phosphate isomerase	Rattus norvegicus	50-53
8178955-1	1994	We examined the effects of calcitonin gene-related peptide (CGRP), forskolin, phorbol 12-myristate 13-acetate (PMA), and ionomycin on the intracellular pH (pHi) dependence of Na-H exchange in UMR-106 cells.	Tetradecanoylphorbol Acetate	78-109	glucose-6-phosphate isomerase	Rattus norvegicus	156-159
7908680-5	1994	Induction of TGK mRNA in response to TPA treatment is transient, reaching a peak at 6-8 h and returning to baseline by 24 h. In contrast, elevation of TGK mRNA levels in response to Ca++ persists for at least 24 h. The increased abundance of TGK mRNA reflects increased transcription of the TGK gene, based on nuclear run-on analysis of Ca(++)- and TPA-treated keratinocytes.	Tetradecanoylphorbol Acetate	349-352	transglutaminase 1, K polypeptide	Mus musculus	151-154
8229768-2	1993	The purpose of this investigation was to study the role of phospholipase A2 (PLA2), arachidonic acid (AA), its metabolites, and protein kinase C (PKC) in the mechanism of PMA-stimulated O2- generation of liver infiltrated PMN as compared to circulating blood PMN.	Tetradecanoylphorbol Acetate	171-174	phospholipase A2 group IB	Rattus norvegicus	59-75
8229768-2	1993	The purpose of this investigation was to study the role of phospholipase A2 (PLA2), arachidonic acid (AA), its metabolites, and protein kinase C (PKC) in the mechanism of PMA-stimulated O2- generation of liver infiltrated PMN as compared to circulating blood PMN.	Tetradecanoylphorbol Acetate	171-174	phospholipase A2 group IB	Rattus norvegicus	77-81
7908680-5	1994	Induction of TGK mRNA in response to TPA treatment is transient, reaching a peak at 6-8 h and returning to baseline by 24 h. In contrast, elevation of TGK mRNA levels in response to Ca++ persists for at least 24 h. The increased abundance of TGK mRNA reflects increased transcription of the TGK gene, based on nuclear run-on analysis of Ca(++)- and TPA-treated keratinocytes.	Tetradecanoylphorbol Acetate	349-352	transglutaminase 1, K polypeptide	Mus musculus	151-154
7690030-4	1993	Western blotting analysis revealed that K+ depletion induced a 2.2-fold increase in GLUT4 in plasma membranes from basal cells, enhanced the PMA-stimulated GLUT4 translocation by 4-fold, and increased the 5-fold insulin-stimulated GLUT4 translocation by 15%, indicating the presence of an inactive GLUT4 intermediate.	Tetradecanoylphorbol Acetate	141-144	solute carrier family 2 member 4	Rattus norvegicus	156-161
7908680-6	1994	Induction of TGK mRNA by either TPA or Ca++ is blocked in the presence of cycloheximide, suggesting that a PKC-dependent protein factor is required for TGK gene expression in response to both stimuli.	Tetradecanoylphorbol Acetate	32-35	transglutaminase 1, K polypeptide	Mus musculus	13-16
7908680-7	1994	Furthermore, the accumulation of TGK mRNA in keratinocytes treated with TPA or Ca++ is blocked in cells treated with the PKC inhibitor GF 109203X or bryostatin.	Tetradecanoylphorbol Acetate	72-75	transglutaminase 1, K polypeptide	Mus musculus	33-36
7690030-4	1993	Western blotting analysis revealed that K+ depletion induced a 2.2-fold increase in GLUT4 in plasma membranes from basal cells, enhanced the PMA-stimulated GLUT4 translocation by 4-fold, and increased the 5-fold insulin-stimulated GLUT4 translocation by 15%, indicating the presence of an inactive GLUT4 intermediate.	Tetradecanoylphorbol Acetate	141-144	solute carrier family 2 member 4	Rattus norvegicus	156-161
7690030-4	1993	Western blotting analysis revealed that K+ depletion induced a 2.2-fold increase in GLUT4 in plasma membranes from basal cells, enhanced the PMA-stimulated GLUT4 translocation by 4-fold, and increased the 5-fold insulin-stimulated GLUT4 translocation by 15%, indicating the presence of an inactive GLUT4 intermediate.	Tetradecanoylphorbol Acetate	141-144	solute carrier family 2 member 4	Rattus norvegicus	156-161
16114500-7	2005	In an animal model of chronic inflammation, SAG clearly reduced the edematic response of 7-day model of multiple treatment of TPA (38.1% inhibition at 200 mg/kg/day).	Tetradecanoylphorbol Acetate	126-129	S-antigen, retina and pineal gland (arrestin)	Mus musculus	44-47
8157736-5	1994	Monocytes and in vitro matured macrophages expressed NPY mRNA in response to phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	77-102	neuropeptide Y	Homo sapiens	53-56
8157736-5	1994	Monocytes and in vitro matured macrophages expressed NPY mRNA in response to phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	104-107	neuropeptide Y	Homo sapiens	53-56
15837784-4	2005	Here, we show that TPA functions to decrease the cellular level of the ATM (ataxia telangiectasia mutated) protein, known to repress CS activation (Liao, W.-C., Haimovitz-Friedman, A., Persaud, R., McLoughlin, M., Ehleiter, D., Zhang, N., Gatei, M., Lavin, M., Kolesnick, R., and Fuks, Z.	Tetradecanoylphorbol Acetate	19-22	ATM serine/threonine kinase	Homo sapiens	71-105
7914348-4	1994	We find that activation of the second messenger pathway leading from protein kinase C to the transcription factor AP-1 by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) impairs induction of the TAT gene both by glucocorticoid hormones and cAMP.	Tetradecanoylphorbol Acetate	140-177	tyrosine aminotransferase	Rattus norvegicus	209-212
7914348-4	1994	We find that activation of the second messenger pathway leading from protein kinase C to the transcription factor AP-1 by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) impairs induction of the TAT gene both by glucocorticoid hormones and cAMP.	Tetradecanoylphorbol Acetate	179-182	tyrosine aminotransferase	Rattus norvegicus	209-212
7914348-5	1994	The effects of TPA treatment on chromatin structure of the TAT gene and protein-DNA interactions in vivo were assayed.	Tetradecanoylphorbol Acetate	15-18	tyrosine aminotransferase	Rattus norvegicus	59-62
7914348-6	1994	Under conditions in which TPA impairs glucocorticoid induction of TAT mRNA, the glucocorticoid receptor and other proteins binding within the glucocorticoid-inducible enhancer occupy their binding sites, indicating that inhibition occurs at a later step necessary for transcriptional stimulation.	Tetradecanoylphorbol Acetate	26-29	tyrosine aminotransferase	Rattus norvegicus	66-69
8139548-0	1994	rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.	Tetradecanoylphorbol Acetate	114-150	H3 histone pseudogene 16	Homo sapiens	65-68
8139548-0	1994	rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.	Tetradecanoylphorbol Acetate	152-155	H3 histone pseudogene 16	Homo sapiens	4-7
8373380-6	1993	The expression of VEGF mRNA in myocyte enriched cultures of new born rat ventricles was increased 2 fold by serum, 5 fold by phorbol myristate acetate and 7 fold by hypoxic conditions.	Tetradecanoylphorbol Acetate	125-150	vascular endothelial growth factor A	Rattus norvegicus	18-22
8104388-2	1993	The prognostic significance of tumor proliferative activity (TPA) in colorectal adenocarcinomas (CA) determined by proliferating cell nuclear antigen (PCNA) and Ki-67 staining is not well defined.	Tetradecanoylphorbol Acetate	61-64	proliferating cell nuclear antigen	Homo sapiens	115-149
8104388-2	1993	The prognostic significance of tumor proliferative activity (TPA) in colorectal adenocarcinomas (CA) determined by proliferating cell nuclear antigen (PCNA) and Ki-67 staining is not well defined.	Tetradecanoylphorbol Acetate	61-64	proliferating cell nuclear antigen	Homo sapiens	151-155
8139548-0	1994	rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.	Tetradecanoylphorbol Acetate	152-155	H3 histone pseudogene 16	Homo sapiens	65-68
15837784-8	2005	Gel shift analysis in LNCaP and CWR22-Rv1 cells demonstrated a significant reduction in DNA binding of the Sp1 transcription factor to the ATM promoter, and quantitative reverse transcription-PCR showed a 50% reduction of ATM mRNA between 8 and 16 h of TPA treatment, indicating that TPA inhibits ATM transcription.	Tetradecanoylphorbol Acetate	253-256	ATM serine/threonine kinase	Homo sapiens	222-225
8139548-8	1994	Membrane ruffling was also induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C-activating phorbol ester, but not by Ca2+ ionophore or microinjection of a dominant active Ki-ras p21 mutant (Ki-rasVal-12 p21).	Tetradecanoylphorbol Acetate	76-79	H3 histone pseudogene 16	Homo sapiens	199-202
15837784-8	2005	Gel shift analysis in LNCaP and CWR22-Rv1 cells demonstrated a significant reduction in DNA binding of the Sp1 transcription factor to the ATM promoter, and quantitative reverse transcription-PCR showed a 50% reduction of ATM mRNA between 8 and 16 h of TPA treatment, indicating that TPA inhibits ATM transcription.	Tetradecanoylphorbol Acetate	253-256	ATM serine/threonine kinase	Homo sapiens	222-225
8139548-8	1994	Membrane ruffling was also induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C-activating phorbol ester, but not by Ca2+ ionophore or microinjection of a dominant active Ki-ras p21 mutant (Ki-rasVal-12 p21).	Tetradecanoylphorbol Acetate	76-79	H3 histone pseudogene 16	Homo sapiens	224-227
8396935-4	1993	Phorbol myristate acetate (PMA), another activator of EL4.NOB-1 cells, had an opposite effect to IL-1 in that it increased binding site expression dramatically suggesting different mechanisms of action for these two effectors.	Tetradecanoylphorbol Acetate	0-25	NIN1/RPN12 binding protein 1 homolog	Mus musculus	58-63
8396935-4	1993	Phorbol myristate acetate (PMA), another activator of EL4.NOB-1 cells, had an opposite effect to IL-1 in that it increased binding site expression dramatically suggesting different mechanisms of action for these two effectors.	Tetradecanoylphorbol Acetate	27-30	NIN1/RPN12 binding protein 1 homolog	Mus musculus	58-63
15837784-8	2005	Gel shift analysis in LNCaP and CWR22-Rv1 cells demonstrated a significant reduction in DNA binding of the Sp1 transcription factor to the ATM promoter, and quantitative reverse transcription-PCR showed a 50% reduction of ATM mRNA between 8 and 16 h of TPA treatment, indicating that TPA inhibits ATM transcription.	Tetradecanoylphorbol Acetate	284-287	ATM serine/threonine kinase	Homo sapiens	222-225
8081876-3	1993	EGF-induced phosphorylation and communication inhibition were retained in cells pretreated with phorbol 12-myristate 13-acetate (PMA) to deplete protein kinase C. These results show that the EGF inhibition of communication is tightly linked to protein kinase C-independent phosphorylation of Cx43.	Tetradecanoylphorbol Acetate	96-127	epidermal growth factor	Homo sapiens	0-3
15837784-8	2005	Gel shift analysis in LNCaP and CWR22-Rv1 cells demonstrated a significant reduction in DNA binding of the Sp1 transcription factor to the ATM promoter, and quantitative reverse transcription-PCR showed a 50% reduction of ATM mRNA between 8 and 16 h of TPA treatment, indicating that TPA inhibits ATM transcription.	Tetradecanoylphorbol Acetate	284-287	ATM serine/threonine kinase	Homo sapiens	222-225
8081876-3	1993	EGF-induced phosphorylation and communication inhibition were retained in cells pretreated with phorbol 12-myristate 13-acetate (PMA) to deplete protein kinase C. These results show that the EGF inhibition of communication is tightly linked to protein kinase C-independent phosphorylation of Cx43.	Tetradecanoylphorbol Acetate	96-127	epidermal growth factor	Homo sapiens	191-194
8081876-3	1993	EGF-induced phosphorylation and communication inhibition were retained in cells pretreated with phorbol 12-myristate 13-acetate (PMA) to deplete protein kinase C. These results show that the EGF inhibition of communication is tightly linked to protein kinase C-independent phosphorylation of Cx43.	Tetradecanoylphorbol Acetate	129-132	epidermal growth factor	Homo sapiens	0-3
8081876-3	1993	EGF-induced phosphorylation and communication inhibition were retained in cells pretreated with phorbol 12-myristate 13-acetate (PMA) to deplete protein kinase C. These results show that the EGF inhibition of communication is tightly linked to protein kinase C-independent phosphorylation of Cx43.	Tetradecanoylphorbol Acetate	129-132	epidermal growth factor	Homo sapiens	191-194
8132674-8	1994	Like TIMP-1, TIMP-3 was highly inducible in mouse C3H 10T1/2 fibroblasts by phorbol ester (PMA), epidermal growth factor (EGF), and transforming growth factor-beta 1, but nuclear run-on assays showed that the on/off transcription kinetics were faster for TIMP-3 than TIMP-1.	Tetradecanoylphorbol Acetate	91-94	tissue inhibitor of metalloproteinase 3	Mus musculus	13-19
8135804-2	1994	Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after the treatment of recombinant interferon-gamma (rIFN-gamma) resulted in the increased accumulation of nitrite in the medium.	Tetradecanoylphorbol Acetate	58-89	interferon gamma	Rattus norvegicus	149-159
15824103-2	2005	The activity of other Nox enzymes such as gp91(phox)/Nox2 and Nox1 is known to absolutely require both an organizer protein (p47(phox) or Noxo1) andanactivatorprotein (p67(phox) or Noxa1); for the p47(phox)-dependent activation of these oxidases, treatment of cells with stimulants such as phorbol 12-myristate 13-acetate is also indispensable.	Tetradecanoylphorbol Acetate	290-321	paired Ig-like receptor B	Mus musculus	42-46
8135804-2	1994	Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after the treatment of recombinant interferon-gamma (rIFN-gamma) resulted in the increased accumulation of nitrite in the medium.	Tetradecanoylphorbol Acetate	91-94	interferon gamma	Rattus norvegicus	149-159
15824103-2	2005	The activity of other Nox enzymes such as gp91(phox)/Nox2 and Nox1 is known to absolutely require both an organizer protein (p47(phox) or Noxo1) andanactivatorprotein (p67(phox) or Noxa1); for the p47(phox)-dependent activation of these oxidases, treatment of cells with stimulants such as phorbol 12-myristate 13-acetate is also indispensable.	Tetradecanoylphorbol Acetate	290-321	methionine aminopeptidase 2	Mus musculus	168-171
8359233-10	1993	Taken together, our results suggest the existence of a labile mRNA regulatory protein or proteins, whose actions include destabilization of both c-fms and CSF-1 transcripts after inhibition of TPA-induced monocytic differentiation by dex or CsA.	Tetradecanoylphorbol Acetate	193-196	colony stimulating factor 1	Homo sapiens	155-160
15833736-2	2005	Because HO-1 is up-regulated by NAD(P)H oxidase activators such as lipopolysaccharide and 12-O-tetradecanoylphorbol-13-acetate in monocytic cells, we investigated the gene regulation of HO-1 by the chemical NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride (AEBSF).	Tetradecanoylphorbol Acetate	90-126	heme oxygenase 1	Homo sapiens	8-12
7689605-1	1993	Modulation of expression of the c-kit proto-oncogene product, the receptor for the recently identified stem cell factor, was studied on 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated cultures of CD34+ normal bone marrow progenitor cells, blast cells from patients with primary acute myelogenous leukemia, cells from the leukemia cell lines HEL and MO7E, as well as cultured HMC-1 mast cells.	Tetradecanoylphorbol Acetate	136-172	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	32-37
7689605-1	1993	Modulation of expression of the c-kit proto-oncogene product, the receptor for the recently identified stem cell factor, was studied on 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated cultures of CD34+ normal bone marrow progenitor cells, blast cells from patients with primary acute myelogenous leukemia, cells from the leukemia cell lines HEL and MO7E, as well as cultured HMC-1 mast cells.	Tetradecanoylphorbol Acetate	174-177	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	32-37
7509804-2	1994	With U937 cells, PMA-induced differentiation increased the production of both interstitial collagenase and 92-kDa gelatinase, whereas exposure to 1,25-(OH)2D3 induced full interstitial collagenase expression in the absence of any detectable 92-kDa gelatinase production.	Tetradecanoylphorbol Acetate	17-20	matrix metallopeptidase 1	Homo sapiens	78-102
7509804-2	1994	With U937 cells, PMA-induced differentiation increased the production of both interstitial collagenase and 92-kDa gelatinase, whereas exposure to 1,25-(OH)2D3 induced full interstitial collagenase expression in the absence of any detectable 92-kDa gelatinase production.	Tetradecanoylphorbol Acetate	17-20	matrix metallopeptidase 1	Homo sapiens	172-196
7509804-4	1994	With THP-1 cells, PMA also induced the production of 92-kDa gelatinase fully, but unlike U937 cells, the combination of PMA and 1,25-(OH)2D3 was required for substantial interstitial collagenase biosynthesis.	Tetradecanoylphorbol Acetate	18-21	matrix metallopeptidase 1	Homo sapiens	170-194
7509804-4	1994	With THP-1 cells, PMA also induced the production of 92-kDa gelatinase fully, but unlike U937 cells, the combination of PMA and 1,25-(OH)2D3 was required for substantial interstitial collagenase biosynthesis.	Tetradecanoylphorbol Acetate	120-123	matrix metallopeptidase 1	Homo sapiens	170-194
8120094-12	1994	Finally, PMA stimulates transcytosis of basolaterally internalized transferrin, suggesting that PMA acts to generally stimulate delivery of endocytosed proteins to the apical surface.	Tetradecanoylphorbol Acetate	9-12	inhibitor of carbonic anhydrase	Canis lupus familiaris	67-78
7690517-10	1993	Furthermore, CD5+B lymphocytes obtained from the same two CLL patients (DAT+) produce, in vitro understimulation with phorbal myristate acetate (PMA), monoclonal antibodies which react and bind to RBC.	Tetradecanoylphorbol Acetate	145-148	CD5 molecule	Homo sapiens	13-16
15910736-0	2005	Transcriptional activation of the Egr-1 gene mediated by tetradecanoylphorbol acetate and extracellular signal-regulated protein kinase.	Tetradecanoylphorbol Acetate	57-85	early growth response 1	Homo sapiens	34-39
8325843-5	1993	Fetal calf serum, insulin, IGF-I, 12-O-tetradecanoylphorbol (TPA), and cycloheximide induced a 2.2-kilobase c-fos transcript in neurons.	Tetradecanoylphorbol Acetate	61-64	FBJ osteosarcoma oncogene	Mus musculus	108-113
7509863-3	1994	Treatment of hippocampal neurons with glutamate/glycine (Glu/Gly), ionomycin, or 12-O-tetradecanoylphorbol 13-acetate (TPA) increased 32P labeling of immunoprecipitated alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate (AMPA)-type GluRs by 145%, 180%, and 227%, respectively, of control values.	Tetradecanoylphorbol Acetate	81-117	glutamyl-tRNA synthetase 2, mitochondrial	Homo sapiens	235-240
7509863-3	1994	Treatment of hippocampal neurons with glutamate/glycine (Glu/Gly), ionomycin, or 12-O-tetradecanoylphorbol 13-acetate (TPA) increased 32P labeling of immunoprecipitated alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate (AMPA)-type GluRs by 145%, 180%, and 227%, respectively, of control values.	Tetradecanoylphorbol Acetate	119-122	glutamyl-tRNA synthetase 2, mitochondrial	Homo sapiens	235-240
8325843-12	1993	TPA increased c-fos mRNA levels with similar kinetics to that of insulin and IGF-I; however, the attenuation phase more closely paralleled that of insulin.	Tetradecanoylphorbol Acetate	0-3	FBJ osteosarcoma oncogene	Mus musculus	14-19
8325843-13	1993	Two inhibitors of PKC, sphingosine and staurosporine, completely blocked the induction of c-fos mRNA by insulin, IGF-I, and TPA.	Tetradecanoylphorbol Acetate	124-127	FBJ osteosarcoma oncogene	Mus musculus	90-95
8206325-1	1994	We previously showed that activation of protein kinase C (PKC) with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA) in GT1-7 hypothalamic cells decreases GnRH mRNA levels in a dose and time dependent fashion.	Tetradecanoylphorbol Acetate	87-123	gonadotropin releasing hormone 1	Mus musculus	168-172
8206325-1	1994	We previously showed that activation of protein kinase C (PKC) with the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA) in GT1-7 hypothalamic cells decreases GnRH mRNA levels in a dose and time dependent fashion.	Tetradecanoylphorbol Acetate	125-128	gonadotropin releasing hormone 1	Mus musculus	168-172
8206325-3	1994	Analysis of the half-life of GnRH mRNA levels after transcriptional arrest with actinomycin-D (5 micrograms/ml) estimated the half-life of GnRH mRNA to be 22 h. TPA treatment did not alter the GnRH mRNA half-life directly, suggesting that the effects of TPA occur predominantly at the level of gene transcription.	Tetradecanoylphorbol Acetate	161-164	gonadotropin releasing hormone 1	Rattus norvegicus	29-33
15910736-2	2005	Likewise, the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) strongly upregulates Egr-1 biosynthesis.	Tetradecanoylphorbol Acetate	29-65	early growth response 1	Homo sapiens	93-98
8108142-3	1994	Here we show that in transient transfection assays a mutated form of the murine p53 tumor suppressor gene (ala135--&gt;val) induces expression of VEGF mRNA and potentiates TPA stimulated VEGF mRNA expression.	Tetradecanoylphorbol Acetate	172-175	transformation related protein 53, pseudogene	Mus musculus	80-83
15910736-2	2005	Likewise, the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) strongly upregulates Egr-1 biosynthesis.	Tetradecanoylphorbol Acetate	67-70	early growth response 1	Homo sapiens	93-98
15910736-3	2005	Here, we have analyzed the genetic elements involved in the regulation of Egr-1 gene transcription by ERK and TPA in human hepatoma cells.	Tetradecanoylphorbol Acetate	110-113	early growth response 1	Homo sapiens	74-79
8392062-2	1993	J774 cells responded to either phorbol 12-myristate 13-acetate (PMA) or LPS by the transient increase in the expression levels of c-jun and junB mRNA, but not of junD mRNA.	Tetradecanoylphorbol Acetate	31-62	jun B proto-oncogene	Mus musculus	140-144
15910736-4	2005	Expression experiments using mitogen-activated protein kinase phosphatase-1 or a dominant-negative mutant of the ternary complex factor Elk-1 revealed that the distal cluster of serum response elements is essential in the TPA-induced enhancement of Egr-1 promoter activity, encompassing two independent TPA-responsive elements.	Tetradecanoylphorbol Acetate	222-225	early growth response 1	Homo sapiens	249-254
8392062-2	1993	J774 cells responded to either phorbol 12-myristate 13-acetate (PMA) or LPS by the transient increase in the expression levels of c-jun and junB mRNA, but not of junD mRNA.	Tetradecanoylphorbol Acetate	64-67	jun B proto-oncogene	Mus musculus	140-144
8392062-8	1993	JunB in nuclear fraction appears to specifically bind to 12-O-tetradecanoylphorbol-13-acetate-response element (TRE), since preincubation of nuclear extracts with anti-JunB serum reduced the amount of TRE-binding proteins and since the amount of JunB, but not of c-Jun or JunD, immunoprecipitated from TRE-cross-linked nuclear proteins increased in response to LPS.	Tetradecanoylphorbol Acetate	57-93	jun B proto-oncogene	Mus musculus	0-4
7509207-7	1994	Mast cells from c-kit mutant mice adhere to fibronectin on stimulation with phorbol 12-myristate 13-acetate (PMA), but not on stimulation with steel factor, indicating that stimulation of integrin adhesiveness requires activation of the c-kit protein tyrosine kinase.	Tetradecanoylphorbol Acetate	76-107	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	16-21
8392062-8	1993	JunB in nuclear fraction appears to specifically bind to 12-O-tetradecanoylphorbol-13-acetate-response element (TRE), since preincubation of nuclear extracts with anti-JunB serum reduced the amount of TRE-binding proteins and since the amount of JunB, but not of c-Jun or JunD, immunoprecipitated from TRE-cross-linked nuclear proteins increased in response to LPS.	Tetradecanoylphorbol Acetate	57-93	jun B proto-oncogene	Mus musculus	168-172
7509207-7	1994	Mast cells from c-kit mutant mice adhere to fibronectin on stimulation with phorbol 12-myristate 13-acetate (PMA), but not on stimulation with steel factor, indicating that stimulation of integrin adhesiveness requires activation of the c-kit protein tyrosine kinase.	Tetradecanoylphorbol Acetate	76-107	fibronectin 1	Mus musculus	44-55
15927073-10	2005	To identify the protease(s) responsible, U937 cells were treated with phorbol 12-myristate 13-acetate (PMA), an agent that induces cellular differentiation and results in decreased expression of acid-independent serine proteases, including NE and cathepsin (Cat) G.	Tetradecanoylphorbol Acetate	70-101	cathepsin G	Homo sapiens	247-264
7509207-7	1994	Mast cells from c-kit mutant mice adhere to fibronectin on stimulation with phorbol 12-myristate 13-acetate (PMA), but not on stimulation with steel factor, indicating that stimulation of integrin adhesiveness requires activation of the c-kit protein tyrosine kinase.	Tetradecanoylphorbol Acetate	76-107	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	237-242
7509207-7	1994	Mast cells from c-kit mutant mice adhere to fibronectin on stimulation with phorbol 12-myristate 13-acetate (PMA), but not on stimulation with steel factor, indicating that stimulation of integrin adhesiveness requires activation of the c-kit protein tyrosine kinase.	Tetradecanoylphorbol Acetate	109-112	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	16-21
8392062-8	1993	JunB in nuclear fraction appears to specifically bind to 12-O-tetradecanoylphorbol-13-acetate-response element (TRE), since preincubation of nuclear extracts with anti-JunB serum reduced the amount of TRE-binding proteins and since the amount of JunB, but not of c-Jun or JunD, immunoprecipitated from TRE-cross-linked nuclear proteins increased in response to LPS.	Tetradecanoylphorbol Acetate	57-93	jun B proto-oncogene	Mus musculus	168-172
8392062-8	1993	JunB in nuclear fraction appears to specifically bind to 12-O-tetradecanoylphorbol-13-acetate-response element (TRE), since preincubation of nuclear extracts with anti-JunB serum reduced the amount of TRE-binding proteins and since the amount of JunB, but not of c-Jun or JunD, immunoprecipitated from TRE-cross-linked nuclear proteins increased in response to LPS.	Tetradecanoylphorbol Acetate	57-93	jun D proto-oncogene	Mus musculus	272-276
7509207-7	1994	Mast cells from c-kit mutant mice adhere to fibronectin on stimulation with phorbol 12-myristate 13-acetate (PMA), but not on stimulation with steel factor, indicating that stimulation of integrin adhesiveness requires activation of the c-kit protein tyrosine kinase.	Tetradecanoylphorbol Acetate	109-112	fibronectin 1	Mus musculus	44-55
15626739-9	2005	Consequently, Nef activation caused the inhibition of M-CSF-mediated proliferation of TF-1-fms cells and macrophage differentiation of the cells induced by M-CSF and 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	166-202	colony stimulating factor 1	Homo sapiens	54-59
8119299-1	1994	We have characterized regulation of type-1 plasminogen activator inhibitor (PAI-1) gene expression by phorbol 12-myristate 13-acetate (PMA) and the cAMP-inducing agent forskolin in the human breast carcinoma cell line MCF-7.	Tetradecanoylphorbol Acetate	102-133	serpin family E member 1	Homo sapiens	76-81
8119299-1	1994	We have characterized regulation of type-1 plasminogen activator inhibitor (PAI-1) gene expression by phorbol 12-myristate 13-acetate (PMA) and the cAMP-inducing agent forskolin in the human breast carcinoma cell line MCF-7.	Tetradecanoylphorbol Acetate	135-138	serpin family E member 1	Homo sapiens	76-81
8325370-3	1993	Moreover, EGF could stimulate the formation of [3H]phosphatidic acid in [3H]myristic acid preloaded cells, suggesting that EGF is able to activate cellular phospholipase D. Also, PMA was able to increase the phosphatidic acid formation with a parallel increase in the adenylate cyclase activity.	Tetradecanoylphorbol Acetate	179-182	epidermal growth factor	Bos taurus	10-13
8325370-3	1993	Moreover, EGF could stimulate the formation of [3H]phosphatidic acid in [3H]myristic acid preloaded cells, suggesting that EGF is able to activate cellular phospholipase D. Also, PMA was able to increase the phosphatidic acid formation with a parallel increase in the adenylate cyclase activity.	Tetradecanoylphorbol Acetate	179-182	epidermal growth factor	Bos taurus	123-126
8100719-4	1993	When stimulated with anti-CD3 and phorbol 12-myristate 13-acetate, purified patient CD8+ T cells exhibited significantly decreased proliferation, c-myc expression, and interleukin-2 (IL-2) production compared with that of normal CD8+ T cells.	Tetradecanoylphorbol Acetate	34-65	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	146-151
7508438-4	1994	Chymotrypsin and phorbol 12-myristate 13-acetate treatment of neutrophils caused shedding of L-selectin, but not of class I major histocompatibility complex antigens or beta 2 integrins, and blunted the capability of neutrophils to respond to sulfatides with an increase of cytosolic free calcium.	Tetradecanoylphorbol Acetate	17-48	selectin L	Homo sapiens	93-103
15659537-0	2005	Tumor necrosis factor alpha and phorbol 12-myristate-13-acetate down-regulate human 11beta-hydroxysteroid dehydrogenase type 2 through p50/p50 NF-kappaB homodimers and Egr-1.	Tetradecanoylphorbol Acetate	32-63	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	84-126
8199014-3	1994	Co-stimulation with A23187 plus PMA resulted in an up-regulation of M-CSF mRNA and a down-regulation of IL-6 mRNA.	Tetradecanoylphorbol Acetate	32-35	colony stimulating factor 1	Homo sapiens	68-73
7507209-3	1994	The hepatitis B virus transactivator was able to activate TRE (12-O-tetradecanoylphorbol-13-acetate response element)-directed transcription in different cell lines, including HepG2, HeLa, CV1, and PLC/PRF/5 cells.	Tetradecanoylphorbol Acetate	63-99	heparan sulfate proteoglycan 2	Homo sapiens	198-201
7685674-5	1993	Incubation of TNF- or PMA-stimulated HUVEC with BB11, an anti-E-selectin mAb, prior to the addition of COLO 205, led to almost complete inhibition of adherence of the tumor cells.	Tetradecanoylphorbol Acetate	22-25	selectin E	Homo sapiens	62-72
15659537-0	2005	Tumor necrosis factor alpha and phorbol 12-myristate-13-acetate down-regulate human 11beta-hydroxysteroid dehydrogenase type 2 through p50/p50 NF-kappaB homodimers and Egr-1.	Tetradecanoylphorbol Acetate	32-63	early growth response 1	Homo sapiens	168-173
7686498-6	1993	In contrast, 12-O-tetradecanoylphorbol 13-acetate reduced tyrosinase activity and eumelanin synthesis.	Tetradecanoylphorbol Acetate	13-49	tyrosinase	Mus musculus	58-68
15659537-4	2005	The analysis of the transcriptional regulation of 11beta-HSD2 by TNF-alpha and phorbol 12-myristate-13-acetate (PMA) with in vivo genomic footprinting in human colon SW620 cells revealed stimulus-dependent protein-DNA interactions in three promoter regions, kappaB1, Sp1/Egr-1I, and Sp1/Egr-1II.	Tetradecanoylphorbol Acetate	79-110	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	50-61
7508390-7	1994	Phorbol 12-myristate 13-acetate had an inhibitory effect on brush-border enzyme synthesis, in particular on sucrase-isomaltase, and blocked the forskolin-induced biosynthesis of lactase-phlorizin hydrolase.	Tetradecanoylphorbol Acetate	0-31	sucrase-isomaltase	Homo sapiens	108-126
15659537-4	2005	The analysis of the transcriptional regulation of 11beta-HSD2 by TNF-alpha and phorbol 12-myristate-13-acetate (PMA) with in vivo genomic footprinting in human colon SW620 cells revealed stimulus-dependent protein-DNA interactions in three promoter regions, kappaB1, Sp1/Egr-1I, and Sp1/Egr-1II.	Tetradecanoylphorbol Acetate	112-115	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	50-61
8297348-6	1994	Prolonged (48 h) exposure of cells to the phorbol ester phorbol 12-myristate 13-acetate (PMA; 100 nM) resulted in a marked decrease in the amounts of PKC-alpha and PKC-epsilon, with no change in levels of PKC-zeta.	Tetradecanoylphorbol Acetate	56-87	protein kinase C epsilon	Homo sapiens	164-175
15579495-5	2005	The increased adhesion of N-formyl-methionyl-leucyl-phenylalanine (fMLP; 0.1 microM)- and phorbol myristate acetate (PMA; 1 microM)-treated neutrophils to fibronectin-coated wells did not differ among vehicle- and capsaicin-pretreated rats.	Tetradecanoylphorbol Acetate	90-115	fibronectin 1	Rattus norvegicus	155-166
8297348-6	1994	Prolonged (48 h) exposure of cells to the phorbol ester phorbol 12-myristate 13-acetate (PMA; 100 nM) resulted in a marked decrease in the amounts of PKC-alpha and PKC-epsilon, with no change in levels of PKC-zeta.	Tetradecanoylphorbol Acetate	89-92	protein kinase C epsilon	Homo sapiens	164-175
8292022-5	1994	Stimulation of neutrophils with phorbol myristate acetate (PMA) resulted in enhancement of the oxidase activity to generate O2- anion and was accompanied by substantial translocation of p47phox to membrane.	Tetradecanoylphorbol Acetate	32-57	pleckstrin	Homo sapiens	186-189
8292022-5	1994	Stimulation of neutrophils with phorbol myristate acetate (PMA) resulted in enhancement of the oxidase activity to generate O2- anion and was accompanied by substantial translocation of p47phox to membrane.	Tetradecanoylphorbol Acetate	59-62	pleckstrin	Homo sapiens	186-189
7942278-6	1994	Long-term exposure to TPA depletes cells of PKC alpha and significantly reduces the PKC epsilon levels.	Tetradecanoylphorbol Acetate	22-25	protein kinase C epsilon	Homo sapiens	84-95
8410828-3	1993	Exposure to PMA over 48 h resulted in a significant increase in MMP-1 activity but only a modest and nonsignificant increase in MMP-2 activity.	Tetradecanoylphorbol Acetate	12-15	matrix metallopeptidase 1	Homo sapiens	64-69
8389757-8	1993	Other studies further demonstrate that the jun-B and fra-1 genes are induced by TPA in both HL-60/vinc and HL-60/vinc/R cells, whereas c-fos expression is attenuated in the HL-60/vinc line.	Tetradecanoylphorbol Acetate	80-83	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	53-58
15632189-5	2005	Conversely, activation of PKC by 12-O-tetradecanoylphorbol-13-acetate induced DGK translocation.	Tetradecanoylphorbol Acetate	33-69	protein kinase C epsilon	Homo sapiens	26-29
8394594-8	1993	Brief exposure to 12-tetradecanoylphorbol 13-acetate inhibits NMB-mediated PI turnover but not arachidonate release.	Tetradecanoylphorbol Acetate	18-52	neuromedin B	Mus musculus	62-65
8123590-5	1994	DNA-protein interaction between an evolutionarily conserved region (-73 to -45) of the human NPY promoter, containing potential binding sites for AP-1, AP-2, and Sp1, and nuclear extracts prepared from untreated and TPA-treated SH-SY5Y cells revealed one complex (CI) that was unaffected and three complexes (CII to CIV) that were induced by TPA treatment.	Tetradecanoylphorbol Acetate	216-219	neuropeptide Y	Homo sapiens	93-96
8123590-7	1994	In addition, TPA-mediated induction of AP-2 DNA binding activity to the NPY promoter was not dependent on increased AP-2 mRNA expression.	Tetradecanoylphorbol Acetate	13-16	neuropeptide Y	Homo sapiens	72-75
16095009-7	2005	When whole blood cells were stimulated with LPS or PMA plus ionomycin, but not PHA, BD patients had higher levels of MIP-1alpha in the culture supernatants compared to healthy controls.	Tetradecanoylphorbol Acetate	51-54	C-C motif chemokine ligand 3	Homo sapiens	117-127
8123597-3	1994	p26 mJUN was able to block both 12-O-tetradecanoylphorbol-13-acetate (TPA) and okadaic acid induced expression of the mouse stromelysin gene in 10Gy5 cells and TPA induced expression of the urokinase-type plasminogen activator gene in PDV cells as determined by Northern analyses.	Tetradecanoylphorbol Acetate	160-163	plasminogen activator, urokinase	Mus musculus	190-226
8282054-8	1994	Inhibition of GM-CSF binding by a combination of ET-18-OCH3 (10 microM) and TPA (1 or 10 nM) was less than additive, and ET-18-OCH3 partially inhibited TPA-induced protein kinase C (PKC) depletion in the cytosol and translocation to the particulate fractions.	Tetradecanoylphorbol Acetate	152-155	colony stimulating factor 2	Homo sapiens	14-20
8500615-4	1993	Thus p59fyn could replace the calcium ionophore but not activation of protein kinase C. The activation by p59fyn plus PMA was blocked by EGTA and by the immunosuppressant drug cyclosporin A.	Tetradecanoylphorbol Acetate	118-121	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	5-11
8502243-2	1993	PGCP mRNA was strongly induced in EL4.E1 cells by phorbol myristate acetate, which also induces mRNAs for several cytokines in these cells.	Tetradecanoylphorbol Acetate	50-75	carboxypeptidase Q	Mus musculus	0-4
8389144-1	1993	Thrombomodulin (TM) antigen and its cofactor activity for thrombin-dependent protein C activation were not detected in the untreated HL-60 human promyelocytic cell line, but appeared in cells cultured with 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3: 10-1,000 nM) or phorbol 12-myristate 13-acetate (PMA: 0.1-10 nM) accompanied by an increase in TM mRNA levels.	Tetradecanoylphorbol Acetate	273-304	thrombomodulin	Homo sapiens	0-14
8282054-9	1994	It is suggested that the inhibition of GM-CSF binding by ET-18-OCH3 is due in part to disruption of the plasma membrane and that the inhibition of GM-CSF binding by TPA is due to activation of PKC.	Tetradecanoylphorbol Acetate	165-168	colony stimulating factor 2	Homo sapiens	147-153
8254739-6	1994	One sequence motif is shown to constitutively bind CREB- and Jun-related proteins in both keratinocytes and fibroblasts, whereas the other is a target for TPA-induced c-Rel/p65(NF-kappa B)-binding activity specifically in keratinocytes.	Tetradecanoylphorbol Acetate	155-158	reticuloendotheliosis oncogene	Mus musculus	167-172
8254739-6	1994	One sequence motif is shown to constitutively bind CREB- and Jun-related proteins in both keratinocytes and fibroblasts, whereas the other is a target for TPA-induced c-Rel/p65(NF-kappa B)-binding activity specifically in keratinocytes.	Tetradecanoylphorbol Acetate	155-158	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	173-176
15611126-6	2005	Knockdown of PKCepsilon alone had no effect, but simultaneous knockdown of both PKCalpha and PKCepsilon in C4-2 cells that continued to express normal levels of PKCdelta inhibited PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	180-183	protein kinase C epsilon	Homo sapiens	93-103
7507197-5	1994	Cytoplasmic and cytoskeletal concentrations of actin and tropomyosin decreased to different degrees after treatment with TPA, AZA or DAG in HH39 myocardiocytes.	Tetradecanoylphorbol Acetate	121-124	actin, beta	Gallus gallus	47-52
15627980-2	2005	Treatment with 12-o--tetradecanoyl phorbol 13-acetate (TPA), inducing macrophage-like differentiation, produces a dramatic decrease of MHC-II expression as result of down-modulation of the activation of immune response gene 1 (AIR-1)-encoded MHC-II transactivator (CIITA).	Tetradecanoylphorbol Acetate	15-53	class II major histocompatibility complex transactivator	Homo sapiens	265-270
8389144-1	1993	Thrombomodulin (TM) antigen and its cofactor activity for thrombin-dependent protein C activation were not detected in the untreated HL-60 human promyelocytic cell line, but appeared in cells cultured with 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3: 10-1,000 nM) or phorbol 12-myristate 13-acetate (PMA: 0.1-10 nM) accompanied by an increase in TM mRNA levels.	Tetradecanoylphorbol Acetate	273-304	thrombomodulin	Homo sapiens	16-18
8389144-3	1993	The TM antigen level induced in 1 alpha,25(OH)2D3-treated cells was 8 times higher than that in PMA-treated cells.	Tetradecanoylphorbol Acetate	96-99	thrombomodulin	Homo sapiens	4-6
15627980-2	2005	Treatment with 12-o--tetradecanoyl phorbol 13-acetate (TPA), inducing macrophage-like differentiation, produces a dramatic decrease of MHC-II expression as result of down-modulation of the activation of immune response gene 1 (AIR-1)-encoded MHC-II transactivator (CIITA).	Tetradecanoylphorbol Acetate	55-58	class II major histocompatibility complex transactivator	Homo sapiens	265-270
7520816-2	1994	The expression of E-selectin was induced by tumour necrosis factor-alpha (TNF-alpha, 300 U/ml), phorbol ester (PMA, 10 ng/ml) and bacterial lipopolysaccharide (LPS, 4 micrograms/ml).	Tetradecanoylphorbol Acetate	111-114	selectin E	Homo sapiens	18-28
15627980-5	2005	Molecular studies demonstrate that TPA treatment affects the stability of CIITA mRNA rather than CIITA transcription.	Tetradecanoylphorbol Acetate	35-38	class II major histocompatibility complex transactivator	Homo sapiens	74-79
15673968-4	2005	Phorbol 12-myristate 13 acetate (PMA) enhanced PI-9 mRNA expression in the CD8+ T lymphocyte clone and YT-N10 cells prior to GrB mRNA expression.	Tetradecanoylphorbol Acetate	33-36	granzyme B	Homo sapiens	125-128
8186461-1	1994	Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2) are produced by stimulation with phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) in human T cell leukemia Jurkat cells.	Tetradecanoylphorbol Acetate	146-149	colony stimulating factor 2	Homo sapiens	0-48
8186461-1	1994	Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2) are produced by stimulation with phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) in human T cell leukemia Jurkat cells.	Tetradecanoylphorbol Acetate	146-149	colony stimulating factor 2	Homo sapiens	50-56
8186461-6	1994	We also found that the active CN partially replaces calcium ionophore in synergy with PMA to induce expression of endogenous GM-CSF and IL-2.	Tetradecanoylphorbol Acetate	86-89	colony stimulating factor 2	Homo sapiens	125-131
8264601-11	1994	Together, these results indicate that the TPA response in Drosophila cells stimulates specific transcription of RNA polymerase III genes by increasing the activity of the limiting transcription component, TFIIIB, and thereby increasing the number of functional transcription complexes.	Tetradecanoylphorbol Acetate	42-45	Brf RNA polymerase III subunit	Drosophila melanogaster	205-211
8511989-8	1993	However, phorbol myristate acetate (PMA), an activator of protein kinase C, was a potent stimulator of LIF message in Saos-2 but not U-2 OS cells.	Tetradecanoylphorbol Acetate	9-34	LIF interleukin 6 family cytokine	Homo sapiens	103-106
8511989-8	1993	However, phorbol myristate acetate (PMA), an activator of protein kinase C, was a potent stimulator of LIF message in Saos-2 but not U-2 OS cells.	Tetradecanoylphorbol Acetate	36-39	LIF interleukin 6 family cytokine	Homo sapiens	103-106
8473746-4	1993	Maximal induction of IRAP mRNA was observed between 8 and 16 h after stimulation with IL-1 alpha (1 U/ml), TNF-alpha (10 U/ml), LPS (50 ng/ml), and PMA (10 ng/ml).	Tetradecanoylphorbol Acetate	148-151	interleukin 1 receptor antagonist	Homo sapiens	21-25
15639337-9	2005	While TPA-induced activation of nuclear factor-(kappa)B remained unaffected by both extracts, they inhibited TPA-induced activation of activator protein-1 (AP-1) and attenuated the expression of its key component c-Fos.	Tetradecanoylphorbol Acetate	6-9	FBJ osteosarcoma oncogene	Mus musculus	213-218
8473310-3	1993	This protein was identified as p56lck based on its specific immunoprecipitation with polyclonal antisera to p56lck, by induction of a shift in its electrophoretic mobility following treatment of cells with 12-O-tetradecanoylphorbol-13-acetate and by co-chromatography with p56lck on protamine-agarose.	Tetradecanoylphorbol Acetate	206-242	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	31-37
8473310-3	1993	This protein was identified as p56lck based on its specific immunoprecipitation with polyclonal antisera to p56lck, by induction of a shift in its electrophoretic mobility following treatment of cells with 12-O-tetradecanoylphorbol-13-acetate and by co-chromatography with p56lck on protamine-agarose.	Tetradecanoylphorbol Acetate	206-242	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	108-114
8302296-6	1994	Phorbol myristate acetate induced Egr-1 mRNA expression but forskolin and dibutyryl cyclic AMP did not.	Tetradecanoylphorbol Acetate	0-25	early growth response 1	Homo sapiens	34-39
8473310-3	1993	This protein was identified as p56lck based on its specific immunoprecipitation with polyclonal antisera to p56lck, by induction of a shift in its electrophoretic mobility following treatment of cells with 12-O-tetradecanoylphorbol-13-acetate and by co-chromatography with p56lck on protamine-agarose.	Tetradecanoylphorbol Acetate	206-242	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	108-114
15639337-9	2005	While TPA-induced activation of nuclear factor-(kappa)B remained unaffected by both extracts, they inhibited TPA-induced activation of activator protein-1 (AP-1) and attenuated the expression of its key component c-Fos.	Tetradecanoylphorbol Acetate	109-112	FBJ osteosarcoma oncogene	Mus musculus	213-218
8473351-1	1993	PKC gamma differs from PKC alpha and -beta II and nPKC epsilon in its competence to mediate-12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive transcriptional activation through a TPA-response element.	Tetradecanoylphorbol Acetate	91-129	protein kinase C gamma	Homo sapiens	0-9
8473351-1	1993	PKC gamma differs from PKC alpha and -beta II and nPKC epsilon in its competence to mediate-12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive transcriptional activation through a TPA-response element.	Tetradecanoylphorbol Acetate	91-129	protein kinase C epsilon	Homo sapiens	50-62
8473351-1	1993	PKC gamma differs from PKC alpha and -beta II and nPKC epsilon in its competence to mediate-12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive transcriptional activation through a TPA-response element.	Tetradecanoylphorbol Acetate	131-134	protein kinase C gamma	Homo sapiens	0-9
8473351-1	1993	PKC gamma differs from PKC alpha and -beta II and nPKC epsilon in its competence to mediate-12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive transcriptional activation through a TPA-response element.	Tetradecanoylphorbol Acetate	131-134	protein kinase C epsilon	Homo sapiens	50-62
8473351-1	1993	PKC gamma differs from PKC alpha and -beta II and nPKC epsilon in its competence to mediate-12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive transcriptional activation through a TPA-response element.	Tetradecanoylphorbol Acetate	184-187	protein kinase C gamma	Homo sapiens	0-9
8463210-8	1993	The enhanced influx of calcium by calcium ionophore or the activation of protein kinase C by phorbol myristate acetate induced tyrosine phosphorylation of pp125FAK only in adherent cells.	Tetradecanoylphorbol Acetate	93-118	protein tyrosine kinase 2	Rattus norvegicus	155-163
8463255-0	1993	A polyomavirus enhancer A-binding protein-3 site and Ets-2 protein have a major role in the 12-O-tetradecanoylphorbol-13-acetate response of the human stromelysin gene.	Tetradecanoylphorbol Acetate	92-128	ETS proto-oncogene 2, transcription factor	Homo sapiens	53-58
8463255-9	1993	These data suggest that the PEA-3 site, but not the activator protein-1 site, and Ets-2 protein have a major role in the TPA induction of the human stromelysin gene transcription.	Tetradecanoylphorbol Acetate	121-124	ETS proto-oncogene 2, transcription factor	Homo sapiens	82-87
7680961-2	1993	Here we show that active (phorbol myristate acetate, phorbol dibutyrate acetate, and mezerein) but not inactive (4 beta-phorbol) tumor-promoting agents inhibit the mAb-induced modulation of CD2 and CD5, but not CD3, without concomitant changes in the surface distribution of these antigens (such as capping).	Tetradecanoylphorbol Acetate	26-51	CD2 molecule	Homo sapiens	190-193
7680961-2	1993	Here we show that active (phorbol myristate acetate, phorbol dibutyrate acetate, and mezerein) but not inactive (4 beta-phorbol) tumor-promoting agents inhibit the mAb-induced modulation of CD2 and CD5, but not CD3, without concomitant changes in the surface distribution of these antigens (such as capping).	Tetradecanoylphorbol Acetate	26-51	CD5 molecule	Homo sapiens	198-201
8495968-5	1993	IFN-gamma production by phytohaemagglutinin (PHA)- or ionomycin and phorbol myristate acetate (PMA)-stimulated splenocytes or purified splenic T cells from animals immunized with antigen and ricin was substantially reduced as compared with animals which were given saline or antigen alone (P &lt; 0.001 Student"s t-test).	Tetradecanoylphorbol Acetate	68-93	interferon gamma	Rattus norvegicus	0-9
8495968-5	1993	IFN-gamma production by phytohaemagglutinin (PHA)- or ionomycin and phorbol myristate acetate (PMA)-stimulated splenocytes or purified splenic T cells from animals immunized with antigen and ricin was substantially reduced as compared with animals which were given saline or antigen alone (P &lt; 0.001 Student"s t-test).	Tetradecanoylphorbol Acetate	95-98	interferon gamma	Rattus norvegicus	0-9
7681075-6	1993	Cell lines expressing single amino acid substitutions of the carboxyl-terminal asparagine of CD2 are incapable of avidity regulation by TCR signaling, PMA treatment, or elevation of intracellular cAMP levels, demonstrating that each of these stimuli utilizes a common structural element for regulating CD2 avidity.	Tetradecanoylphorbol Acetate	151-154	CD2 molecule	Homo sapiens	93-96
8462673-6	1993	TPA strongly induced PGHS-2 protein and also increased the amount of PGHS-1 protein.	Tetradecanoylphorbol Acetate	0-3	prostaglandin-endoperoxide synthase 1	Mus musculus	69-75
8461005-6	1993	In contrast, both TPA and bryostatin 1 stimulated translocation and a partial down-regulation of PKC-epsilon with similar kinetics.	Tetradecanoylphorbol Acetate	18-21	protein kinase C epsilon	Homo sapiens	97-108
8461900-1	1993	An assessment was made of the ability of human skin fibroblasts from newborn and old subjects to produce intracellular urokinase inhibitor and urokinase-plasminogen activator when exposed to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	191-216	serpin family B member 2	Homo sapiens	119-138
8334226-2	1993	In T lymphocytes all genes: platelet basic protein (PBP); platelet factor 4 (PF-4); IL-8/NAP-1; IP-10; GRO; pAT464 and pAT744 were induced by stimulation with phytohemagglutinin and phorbol 12-myristate 13-acetate (PHA/PMA).	Tetradecanoylphorbol Acetate	182-213	C-C motif chemokine ligand 4	Homo sapiens	119-125
8436616-3	1993	A single intracisternal injection of TP (5 x 10(-9) M in the CSF) induced sustained contraction lasting over 3 days, which almost paralleled the changes of membrane-bound PKC activity in the basilar arterial wall.	Tetradecanoylphorbol Acetate	37-39	colony stimulating factor 2	Homo sapiens	61-64
8095965-11	1993	In conclusion, PMA induces release of ECP from single adherent eosinophils and the effect appears to be mediated via protein kinase C and, in contrast to that in neutrophils, to be dependent on CD11/CD18 leukocyte integrins.	Tetradecanoylphorbol Acetate	15-18	lymphotoxin beta receptor	Homo sapiens	199-203
8461254-6	1993	The presence of the protein synthesis inhibitor cycloheximide completely prevented PMA-induced synthesis of IL-5 mRNA by both NIMP-TH1 and EL-4 cells, indicating that induction of IL-5 mRNA via PMA stimulation requires de novo synthesis of a presumptive trans-acting factor(s).	Tetradecanoylphorbol Acetate	83-86	interleukin 5	Mus musculus	108-112
8461254-6	1993	The presence of the protein synthesis inhibitor cycloheximide completely prevented PMA-induced synthesis of IL-5 mRNA by both NIMP-TH1 and EL-4 cells, indicating that induction of IL-5 mRNA via PMA stimulation requires de novo synthesis of a presumptive trans-acting factor(s).	Tetradecanoylphorbol Acetate	83-86	interleukin 5	Mus musculus	180-184
8441391-4	1993	Either decreased expression of endogenous normal ras in fibroblasts transfected with an inducible antisense ras construct or overexpression of a mutant ras gene reduced the capacity of the phorbol ester tetradecanoyl phorbol acetate to trigger expression of the tetradecanoyl phorbol acetate-responsive and ras-dependent reporter gene osteopontin (OPN).	Tetradecanoylphorbol Acetate	203-232	secreted phosphoprotein 1	Homo sapiens	335-346
8441391-4	1993	Either decreased expression of endogenous normal ras in fibroblasts transfected with an inducible antisense ras construct or overexpression of a mutant ras gene reduced the capacity of the phorbol ester tetradecanoyl phorbol acetate to trigger expression of the tetradecanoyl phorbol acetate-responsive and ras-dependent reporter gene osteopontin (OPN).	Tetradecanoylphorbol Acetate	203-232	secreted phosphoprotein 1	Homo sapiens	348-351
8439327-0	1993	An AP-1 enhancer mediates TPA-induced transcriptional activation of the chicken insulin-like growth factor I gene.	Tetradecanoylphorbol Acetate	26-29	insulin like growth factor 1	Gallus gallus	80-108
8457378-4	1993	RNA blot analysis showed that the level of mRNA for TAXREB107 increased transiently in Jurkat cells on treatment with TPA.	Tetradecanoylphorbol Acetate	118-121	ribosomal protein L6	Homo sapiens	52-61
8302585-0	1994	c-Myb prevents TPA-induced differentiation and cell death in v-Myb transformed monoblasts.	Tetradecanoylphorbol Acetate	15-18	MYB proto-oncogene, transcription factor	Homo sapiens	0-5
8302585-0	1994	c-Myb prevents TPA-induced differentiation and cell death in v-Myb transformed monoblasts.	Tetradecanoylphorbol Acetate	15-18	MYB proto-oncogene, transcription factor	Homo sapiens	2-5
8302585-4	1994	However, the response to phorbol ester (TPA) was significantly altered by c-Myb.	Tetradecanoylphorbol Acetate	40-43	MYB proto-oncogene, transcription factor	Homo sapiens	74-79
8302585-5	1994	Monoblasts transformed by v-Myb can be induced to differentiate into macrophages by treatment with TPA.	Tetradecanoylphorbol Acetate	99-102	MYB proto-oncogene, transcription factor	Homo sapiens	26-31
8302585-7	1994	However, when c-Myb was made TPA-inducible in these cells, TPA-induced differentiation into macrophages was blocked and cell death was prevented.	Tetradecanoylphorbol Acetate	29-32	MYB proto-oncogene, transcription factor	Homo sapiens	14-19
8302585-7	1994	However, when c-Myb was made TPA-inducible in these cells, TPA-induced differentiation into macrophages was blocked and cell death was prevented.	Tetradecanoylphorbol Acetate	59-62	MYB proto-oncogene, transcription factor	Homo sapiens	14-19
8262983-2	1993	Transient expression of actively mutated Fyn, having Phe-528 instead of Tyr-528 or Thr-338 instead of Ile-338, in Jurkat T-cells stimulated the serum response element (SRE), 12-O-tetradecanoyl-phorbol-13-acetate response element, cyclic AMP response element, and c-fos promoter.	Tetradecanoylphorbol Acetate	174-211	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	41-44
8280132-5	1993	In addition, GF 109203X completely inhibited TPA-induced increase in cellular content of noradrenaline as well as stimulation of expression of neuropeptide Y, growth-associated protein-43 and c-fos proto-oncogene mRNA by TPA.	Tetradecanoylphorbol Acetate	221-224	neuropeptide Y	Homo sapiens	143-157
8280132-5	1993	In addition, GF 109203X completely inhibited TPA-induced increase in cellular content of noradrenaline as well as stimulation of expression of neuropeptide Y, growth-associated protein-43 and c-fos proto-oncogene mRNA by TPA.	Tetradecanoylphorbol Acetate	221-224	growth associated protein 43	Homo sapiens	159-187
7694866-10	1993	Treatment with tetradecanoyl phorbol acetate (TPA), a potent activator of protein kinase C (PKC), in combination with IL-7 induced a level of c-myc expression greater than that elicited by either factor alone, suggesting that TPA and IL-7 utilize cooperative signaling pathways to increase c-myc gene expression.	Tetradecanoylphorbol Acetate	15-44	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	142-147
7694866-10	1993	Treatment with tetradecanoyl phorbol acetate (TPA), a potent activator of protein kinase C (PKC), in combination with IL-7 induced a level of c-myc expression greater than that elicited by either factor alone, suggesting that TPA and IL-7 utilize cooperative signaling pathways to increase c-myc gene expression.	Tetradecanoylphorbol Acetate	15-44	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	290-295
7694866-10	1993	Treatment with tetradecanoyl phorbol acetate (TPA), a potent activator of protein kinase C (PKC), in combination with IL-7 induced a level of c-myc expression greater than that elicited by either factor alone, suggesting that TPA and IL-7 utilize cooperative signaling pathways to increase c-myc gene expression.	Tetradecanoylphorbol Acetate	46-49	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	142-147
7694866-10	1993	Treatment with tetradecanoyl phorbol acetate (TPA), a potent activator of protein kinase C (PKC), in combination with IL-7 induced a level of c-myc expression greater than that elicited by either factor alone, suggesting that TPA and IL-7 utilize cooperative signaling pathways to increase c-myc gene expression.	Tetradecanoylphorbol Acetate	46-49	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	290-295
8218360-0	1993	Decrease in the phosphotyrosine phosphatase activity in the plasma membrane of human neutrophils on stimulation by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	115-146	cell division cycle 25C	Homo sapiens	16-43
8218360-1	1993	Phorbol 12-myristate 13-acetate (PMA) induced a decrease in the phosphotyrosine phosphatase (PTPase) activity in human neurophils.	Tetradecanoylphorbol Acetate	0-31	cell division cycle 25C	Homo sapiens	64-91
8218360-1	1993	Phorbol 12-myristate 13-acetate (PMA) induced a decrease in the phosphotyrosine phosphatase (PTPase) activity in human neurophils.	Tetradecanoylphorbol Acetate	0-31	cell division cycle 25C	Homo sapiens	93-99
8218360-1	1993	Phorbol 12-myristate 13-acetate (PMA) induced a decrease in the phosphotyrosine phosphatase (PTPase) activity in human neurophils.	Tetradecanoylphorbol Acetate	33-36	cell division cycle 25C	Homo sapiens	64-91
8218360-1	1993	Phorbol 12-myristate 13-acetate (PMA) induced a decrease in the phosphotyrosine phosphatase (PTPase) activity in human neurophils.	Tetradecanoylphorbol Acetate	33-36	cell division cycle 25C	Homo sapiens	93-99
8218360-8	1993	When the plasma membrane was treated with trypsin, the PTPase of the membrane from PMA-treated cells was mostly protected from the proteinase attack while that from the resting cells was not protected.	Tetradecanoylphorbol Acetate	83-86	cell division cycle 25C	Homo sapiens	55-61
8218360-9	1993	Pretreatment of the plasma membrane with Triton X-100 enabled trypsin to gain access to all the PTPase in the membrane from both PMA-treated and resting cells.	Tetradecanoylphorbol Acetate	129-132	cell division cycle 25C	Homo sapiens	96-102
8218360-10	1993	The PMA treatment affected neither subcellular localization of the PTPase nor the orientation of the plasma membrane vesicles.	Tetradecanoylphorbol Acetate	4-7	cell division cycle 25C	Homo sapiens	67-73
8218362-1	1993	We previously reported that protein kinase C (PKC) stimulation through phorbol ester (TPA) treatment enhances the effects of all-trans retinoic acid (RA) on immunophenotypic differentiation and RA nuclear receptor (RAR) activation in the multipotential human teratocarcinoma (TC) cell line NTera-2/clone D1 (abbreviated NT2/D1).	Tetradecanoylphorbol Acetate	86-89	protein kinase C gamma	Homo sapiens	46-49
8218362-1	1993	We previously reported that protein kinase C (PKC) stimulation through phorbol ester (TPA) treatment enhances the effects of all-trans retinoic acid (RA) on immunophenotypic differentiation and RA nuclear receptor (RAR) activation in the multipotential human teratocarcinoma (TC) cell line NTera-2/clone D1 (abbreviated NT2/D1).	Tetradecanoylphorbol Acetate	86-89	retinoic acid receptor alpha	Homo sapiens	194-213
8218362-1	1993	We previously reported that protein kinase C (PKC) stimulation through phorbol ester (TPA) treatment enhances the effects of all-trans retinoic acid (RA) on immunophenotypic differentiation and RA nuclear receptor (RAR) activation in the multipotential human teratocarcinoma (TC) cell line NTera-2/clone D1 (abbreviated NT2/D1).	Tetradecanoylphorbol Acetate	86-89	retinoic acid receptor alpha	Homo sapiens	215-218
8240289-0	1993	Epidermal growth factor and phorbol myristate acetate increase expression of the mRNA for cytosolic phospholipase A2 in glomerular mesangial cells.	Tetradecanoylphorbol Acetate	28-53	phospholipase A2 group IVA	Rattus norvegicus	90-116
8240289-1	1993	We have previously shown that phospholipase A2 (PLA2) activity is rapidly activated by epidermal growth factor (EGF) and phorbol 12-myristate 13-acetate (PMA) in renal mesangial cells and other cell systems in a manner that suggests a covalent modification of the PLA2 enzyme(s).	Tetradecanoylphorbol Acetate	121-152	phospholipase A2 group IB	Rattus norvegicus	30-46
8240289-1	1993	We have previously shown that phospholipase A2 (PLA2) activity is rapidly activated by epidermal growth factor (EGF) and phorbol 12-myristate 13-acetate (PMA) in renal mesangial cells and other cell systems in a manner that suggests a covalent modification of the PLA2 enzyme(s).	Tetradecanoylphorbol Acetate	121-152	phospholipase A2 group IB	Rattus norvegicus	48-52
8240289-1	1993	We have previously shown that phospholipase A2 (PLA2) activity is rapidly activated by epidermal growth factor (EGF) and phorbol 12-myristate 13-acetate (PMA) in renal mesangial cells and other cell systems in a manner that suggests a covalent modification of the PLA2 enzyme(s).	Tetradecanoylphorbol Acetate	154-157	phospholipase A2 group IB	Rattus norvegicus	30-46
8240289-1	1993	We have previously shown that phospholipase A2 (PLA2) activity is rapidly activated by epidermal growth factor (EGF) and phorbol 12-myristate 13-acetate (PMA) in renal mesangial cells and other cell systems in a manner that suggests a covalent modification of the PLA2 enzyme(s).	Tetradecanoylphorbol Acetate	154-157	phospholipase A2 group IB	Rattus norvegicus	48-52
8240289-1	1993	We have previously shown that phospholipase A2 (PLA2) activity is rapidly activated by epidermal growth factor (EGF) and phorbol 12-myristate 13-acetate (PMA) in renal mesangial cells and other cell systems in a manner that suggests a covalent modification of the PLA2 enzyme(s).	Tetradecanoylphorbol Acetate	154-157	phospholipase A2 group IB	Rattus norvegicus	264-268
8404639-5	1993	Furthermore, in PC12 cells, the up-regulation of junB mRNA by activin was observable even after high-dose treatment with 12-O-tetradecanoyl phorbol-13-acetate for 48 h, indicating that junB mRNA expression by activin is independent of both A- and C-kinases.	Tetradecanoylphorbol Acetate	121-158	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-53
8224184-1	1993	Previously, ethanol and the protein kinase C (PKC) activators phorbol 12-myristate 13-acetate (PMA) and bombesin were shown to synergistically stimulate phospholipase C (PLC)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn) in NIH 3T3 fibroblasts.	Tetradecanoylphorbol Acetate	62-93	protein kinase C epsilon	Homo sapiens	46-49
8224184-1	1993	Previously, ethanol and the protein kinase C (PKC) activators phorbol 12-myristate 13-acetate (PMA) and bombesin were shown to synergistically stimulate phospholipase C (PLC)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn) in NIH 3T3 fibroblasts.	Tetradecanoylphorbol Acetate	95-98	protein kinase C epsilon	Homo sapiens	46-49
8231235-6	1993	Treatment of NB-4 cells with all-trans retinoic acid (ATRA) or the phorbol ester TPA induced terminal differentiation and down-regulated annexin VIII mRNA expression rapidly within a few hours; vitamin D3 was ineffective in this regard; the protein kinase C activator Bryostatin 1 up-regulated the expression.	Tetradecanoylphorbol Acetate	81-84	annexin A8 like 1	Homo sapiens	137-149
8114760-1	1993	We report the results of an extensive kinetic analysis of the effects of ACTH, cAMP derivatives (dibutyryl cAMP and 8-bromo-cAMP) and phorbol ester (phorbol-12-myristate-13-acetate) on the expression of fos and jun gene family members at the mRNA (Northern hybridization) and protein levels (immunoprecipitation and indirect immunofluorescence) in the mouse Y-1 adrenocortical cell line.	Tetradecanoylphorbol Acetate	149-180	FBJ osteosarcoma oncogene	Mus musculus	203-206
8414506-6	1993	The tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) attenuated the DNA damage-induced increase in p53-DNA binding activity by decreasing the half-life of the p53 protein.	Tetradecanoylphorbol Acetate	19-56	transformation related protein 53, pseudogene	Mus musculus	109-112
8414506-6	1993	The tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) attenuated the DNA damage-induced increase in p53-DNA binding activity by decreasing the half-life of the p53 protein.	Tetradecanoylphorbol Acetate	19-56	transformation related protein 53, pseudogene	Mus musculus	169-172
8414506-6	1993	The tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) attenuated the DNA damage-induced increase in p53-DNA binding activity by decreasing the half-life of the p53 protein.	Tetradecanoylphorbol Acetate	58-61	transformation related protein 53, pseudogene	Mus musculus	109-112
8414506-6	1993	The tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) attenuated the DNA damage-induced increase in p53-DNA binding activity by decreasing the half-life of the p53 protein.	Tetradecanoylphorbol Acetate	58-61	transformation related protein 53, pseudogene	Mus musculus	169-172
8414506-7	1993	The tumor promoter properties of TPA may therefore be mediated by interfering with the cellular p53 response to DNA damage.	Tetradecanoylphorbol Acetate	33-36	transformation related protein 53, pseudogene	Mus musculus	96-99
8240350-1	1993	The cis-acting element of the granulocyte-macrophage colony-stimulating factor (GM-CSF) promoter, CLE0, is required for stimulation dependent expression of the GM-CSF gene by phorbol ester (PMA) and calcium ionophore (A23187) in T cells.	Tetradecanoylphorbol Acetate	190-193	colony stimulating factor 2	Homo sapiens	30-78
8240350-1	1993	The cis-acting element of the granulocyte-macrophage colony-stimulating factor (GM-CSF) promoter, CLE0, is required for stimulation dependent expression of the GM-CSF gene by phorbol ester (PMA) and calcium ionophore (A23187) in T cells.	Tetradecanoylphorbol Acetate	190-193	colony stimulating factor 2	Homo sapiens	80-86
8240350-1	1993	The cis-acting element of the granulocyte-macrophage colony-stimulating factor (GM-CSF) promoter, CLE0, is required for stimulation dependent expression of the GM-CSF gene by phorbol ester (PMA) and calcium ionophore (A23187) in T cells.	Tetradecanoylphorbol Acetate	190-193	colony stimulating factor 2	Homo sapiens	160-166
8405436-7	1993	After treatment of the cells with 1 microM TPA for 17 h, cPKC alpha, nPKC delta and nPKC epsilon were almost completely down-regulated, whereas aPKC zeta was still unaffected.	Tetradecanoylphorbol Acetate	43-46	protein kinase C epsilon	Homo sapiens	84-96
8407889-6	1993	Although treatment of the cells with the protein kinase C activator, phorbol 12-myristate 13-acetate also resulted in an induction of both cell attachment to collagen and of p21ras activation, tyrosine phosphorylation was not observed.	Tetradecanoylphorbol Acetate	69-100	HRas proto-oncogene, GTPase	Homo sapiens	174-180
8104537-10	1993	On preactivating the same cells, using phorbol myristate acetate (PMA)/ionomycin on concanavalin A (ConA) or especially PHA, levels of CD26 were upregulated and the immunotoxin effectively inhibited the ability to provide help for B-cell Ig synthesis while leaving intact the CD4-CD26+ and CD4+CD26- populations; an effect observed both functionally and by phenotype.	Tetradecanoylphorbol Acetate	39-64	dipeptidyl peptidase 4	Homo sapiens	135-139
8262550-3	1993	In this paper, we have demonstrated that a rapid hyperphosphorylation of CD27 is induced by a cyclic AMP-inducing agent, forskolin, and a membrane-permeable cAMP analogue, 8-bromo-cAMP, as well as phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	197-228	CD27 molecule	Homo sapiens	73-77
8262550-3	1993	In this paper, we have demonstrated that a rapid hyperphosphorylation of CD27 is induced by a cyclic AMP-inducing agent, forskolin, and a membrane-permeable cAMP analogue, 8-bromo-cAMP, as well as phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	230-233	CD27 molecule	Homo sapiens	73-77
8104222-5	1993	The cytolytic activity of the CD45-negative cells could be stimulated pharmacologically by ionomycin and PMA, which, when added to the cytotoxicity assays, induced killing of tumor targets.	Tetradecanoylphorbol Acetate	105-108	protein tyrosine phosphatase, receptor type, C	Rattus norvegicus	30-34
8402597-9	1993	Inhibition of the TPA response by these retinoids in JB6 cells correlated only with their transcriptional activation of RAR alpha, but not with that of RAR alpha.	Tetradecanoylphorbol Acetate	18-21	retinoic acid receptor alpha	Homo sapiens	120-129
8395530-4	1993	Pretreatment of the cells with TPA (10(-7) M) abolished the subsequent response to IL-1 beta, TGF-alpha, and EGF and at the same time resulted in &gt; 90% reduction of cytosolic protein kinase C activity.	Tetradecanoylphorbol Acetate	31-34	epidermal growth factor	Rattus norvegicus	109-112
8257632-6	1993	BTEB also activated the LTR activity in cooperation with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	57-88	Kruppel like factor 9	Homo sapiens	0-4
8214084-1	1993	We examined the mechanisms whereby phorbol 12-myristate 13-acetate (PMA)-activated rabbit peritoneal neutrophils [polymorphonuclear leukocytes (PMN)] altered endothelial-bound angiotensin-converting enzyme (ACE) activity in cultured bovine pulmonary arterial endothelial cells (EC).	Tetradecanoylphorbol Acetate	35-66	angiotensin-converting enzyme	Oryctolagus cuniculus	176-205
8214084-1	1993	We examined the mechanisms whereby phorbol 12-myristate 13-acetate (PMA)-activated rabbit peritoneal neutrophils [polymorphonuclear leukocytes (PMN)] altered endothelial-bound angiotensin-converting enzyme (ACE) activity in cultured bovine pulmonary arterial endothelial cells (EC).	Tetradecanoylphorbol Acetate	35-66	angiotensin-converting enzyme	Oryctolagus cuniculus	207-210
8214084-1	1993	We examined the mechanisms whereby phorbol 12-myristate 13-acetate (PMA)-activated rabbit peritoneal neutrophils [polymorphonuclear leukocytes (PMN)] altered endothelial-bound angiotensin-converting enzyme (ACE) activity in cultured bovine pulmonary arterial endothelial cells (EC).	Tetradecanoylphorbol Acetate	68-71	angiotensin-converting enzyme	Oryctolagus cuniculus	176-205
8214084-1	1993	We examined the mechanisms whereby phorbol 12-myristate 13-acetate (PMA)-activated rabbit peritoneal neutrophils [polymorphonuclear leukocytes (PMN)] altered endothelial-bound angiotensin-converting enzyme (ACE) activity in cultured bovine pulmonary arterial endothelial cells (EC).	Tetradecanoylphorbol Acetate	68-71	angiotensin-converting enzyme	Oryctolagus cuniculus	207-210
7517736-13	1993	On the other hand, as for uPA, tPA is inhibited by PAI-1.	Tetradecanoylphorbol Acetate	31-34	serpin family E member 1	Homo sapiens	51-56
8243888-2	1993	We report here that, compared to RA treatment alone, RA combined with the PKC stimulator 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced the regulated expression of the immunophenotypic differentiation markers SSEA-3, a globo-series carbohydrate, and the ganglio-series carbohydrate antigens GD2 and GD3.	Tetradecanoylphorbol Acetate	89-125	GRDX	Homo sapiens	304-307
8243888-2	1993	We report here that, compared to RA treatment alone, RA combined with the PKC stimulator 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced the regulated expression of the immunophenotypic differentiation markers SSEA-3, a globo-series carbohydrate, and the ganglio-series carbohydrate antigens GD2 and GD3.	Tetradecanoylphorbol Acetate	127-130	GRDX	Homo sapiens	304-307
8395394-3	1993	12-O-Tetradecanoyl phorbol-13-acetate and cytosine arabinoside produced a coordinate and stable stimulation of both vimentin and A/C lamin expression in U-937 cells.	Tetradecanoylphorbol Acetate	0-37	vimentin	Homo sapiens	116-124
8395394-3	1993	12-O-Tetradecanoyl phorbol-13-acetate and cytosine arabinoside produced a coordinate and stable stimulation of both vimentin and A/C lamin expression in U-937 cells.	Tetradecanoylphorbol Acetate	0-37	lamin A/C	Homo sapiens	133-138
8271267-13	1993	The effect of UTP on Maxi-K channel activity and current amplitude was blocked by pertussis toxin and by phorbol 12-myristate 13-acetate (PMA), but was not modified by okadaic acid, or by inhibitors of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	105-136	potassium calcium-activated channel subfamily M alpha 1	Bos taurus	21-27
8271267-13	1993	The effect of UTP on Maxi-K channel activity and current amplitude was blocked by pertussis toxin and by phorbol 12-myristate 13-acetate (PMA), but was not modified by okadaic acid, or by inhibitors of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	138-141	potassium calcium-activated channel subfamily M alpha 1	Bos taurus	21-27
7690438-9	1993	The functional importance of this aberrant glycosylation is unclear, however, since L-selectin is shed normally from phorbol myristate acetate (PMA)-stimulated CLL cells and since normal and CLL lymphocytes bind equally well in vitro to high endothelial venules.	Tetradecanoylphorbol Acetate	144-147	selectin L	Homo sapiens	84-94
7506807-9	1993	Co-transfection with fos and jun expression vectors mimics the effects of TPA suggesting that AP-1 is in fact the mediator of the observed response.	Tetradecanoylphorbol Acetate	74-77	FBJ osteosarcoma oncogene	Mus musculus	21-24
8349696-7	1993	Platelet-derived growth factor and phorbol myristate acetate, when added to low serum medium, blocked or reversed the effect of serum deprivation on ANPR-C.	Tetradecanoylphorbol Acetate	35-60	natriuretic peptide receptor 3	Rattus norvegicus	149-155
8349696-8	1993	We conclude that synthesis and expression of ANPR-C but not ANPR-A is suppressed by serum, platelet-derived growth factor, and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	127-152	natriuretic peptide receptor 3	Rattus norvegicus	45-51
8373969-8	1993	Pre-exposure with TPA (10(-9) M) for 2.5 h resulted in an increase in the stimulative potency of PGF2 alpha and PGI2, but not of PGE2.	Tetradecanoylphorbol Acetate	18-21	prostaglandin F synthase 2	Bos taurus	97-101
8393756-13	1993	Mepacrine (a phospholipase A2 inhibitor) reduced the A23187- and TPA-induced increase of PGE2.	Tetradecanoylphorbol Acetate	65-68	phospholipase A2	Oryctolagus cuniculus	13-29
8241569-9	1993	Two-dimensional tryptic and chymotryptic phosphopeptide mapping demonstrated that the in vitro phosphopeptides represented a specific subset of the in vivo phosphopeptides produced in response to EGF after chronic TPA treatment.	Tetradecanoylphorbol Acetate	214-217	epidermal growth factor	Homo sapiens	196-199
8314805-2	1993	We report here that expression directed by a junB promoter/chloramphenicol acetyltransferase reporter construct (junB/CAT) is induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor in mouse fibroblast 3T6 cells.	Tetradecanoylphorbol Acetate	157-193	jun B proto-oncogene	Mus musculus	45-49
8314805-2	1993	We report here that expression directed by a junB promoter/chloramphenicol acetyltransferase reporter construct (junB/CAT) is induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor in mouse fibroblast 3T6 cells.	Tetradecanoylphorbol Acetate	157-193	jun B proto-oncogene	Mus musculus	113-117
8314805-2	1993	We report here that expression directed by a junB promoter/chloramphenicol acetyltransferase reporter construct (junB/CAT) is induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor in mouse fibroblast 3T6 cells.	Tetradecanoylphorbol Acetate	195-198	jun B proto-oncogene	Mus musculus	45-49
8314805-2	1993	We report here that expression directed by a junB promoter/chloramphenicol acetyltransferase reporter construct (junB/CAT) is induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor in mouse fibroblast 3T6 cells.	Tetradecanoylphorbol Acetate	195-198	jun B proto-oncogene	Mus musculus	113-117
8314805-2	1993	We report here that expression directed by a junB promoter/chloramphenicol acetyltransferase reporter construct (junB/CAT) is induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor in mouse fibroblast 3T6 cells.	Tetradecanoylphorbol Acetate	195-198	epidermal growth factor	Mus musculus	226-229
8314805-5	1993	SRE1, the nucleotide sequence of which resembles that of the serum response element of the c-fos gene, is activated by TPA, platelet-derived growth factor, and fibroblast growth factor, but these growth-stimulating factors do not induce SRE2-mediated transcription.	Tetradecanoylphorbol Acetate	119-122	FBJ osteosarcoma oncogene	Mus musculus	91-96
8342646-5	1993	Increases in PDGF B-chain, but not PDGF A-chain, were observed within 3 h, maximal within 6 h (13-fold increase), and sustained for 24 h. PKC appeared to be involved because phorbol 12-myristate 13-acetate induced PDGF B-chain mRNA.	Tetradecanoylphorbol Acetate	174-205	platelet derived growth factor subunit B	Bos taurus	13-19
8342646-5	1993	Increases in PDGF B-chain, but not PDGF A-chain, were observed within 3 h, maximal within 6 h (13-fold increase), and sustained for 24 h. PKC appeared to be involved because phorbol 12-myristate 13-acetate induced PDGF B-chain mRNA.	Tetradecanoylphorbol Acetate	174-205	platelet derived growth factor subunit B	Bos taurus	214-220
8352523-3	1993	The results showed that TPA down-modulated the constitutive expression of c-myc, c-myb, and c-fms, mRNA to low but still detectable levels.	Tetradecanoylphorbol Acetate	24-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	74-79
8352523-3	1993	The results showed that TPA down-modulated the constitutive expression of c-myc, c-myb, and c-fms, mRNA to low but still detectable levels.	Tetradecanoylphorbol Acetate	24-27	MYB proto-oncogene, transcription factor	Homo sapiens	81-86
8104885-6	1993	However, when the stimulation signals were bypassed by ionomycin and phorbol 12-myristate 13-acetate (PMA), IL-2 was normally produced, suggesting that the IL-2 gene and nuclear factors for the IL-2 gene transcription are normal in LEC rats.	Tetradecanoylphorbol Acetate	102-105	interleukin 2	Rattus norvegicus	108-112
8104885-6	1993	However, when the stimulation signals were bypassed by ionomycin and phorbol 12-myristate 13-acetate (PMA), IL-2 was normally produced, suggesting that the IL-2 gene and nuclear factors for the IL-2 gene transcription are normal in LEC rats.	Tetradecanoylphorbol Acetate	102-105	interleukin 2	Rattus norvegicus	156-160
8104885-6	1993	However, when the stimulation signals were bypassed by ionomycin and phorbol 12-myristate 13-acetate (PMA), IL-2 was normally produced, suggesting that the IL-2 gene and nuclear factors for the IL-2 gene transcription are normal in LEC rats.	Tetradecanoylphorbol Acetate	102-105	interleukin 2	Rattus norvegicus	156-160
8391006-1	1993	Although a weak direct stimulus of superoxide anion (O2-) production, platelet-activating factor (PAF) markedly enhances responses to chemotactic peptides (such as n-formyl-met-leu-phe, FMLP) and phorbol esters (such as phorbol myristate acetate, PMA) in human neutrophils.	Tetradecanoylphorbol Acetate	220-245	PCNA clamp associated factor	Homo sapiens	70-96
8391006-1	1993	Although a weak direct stimulus of superoxide anion (O2-) production, platelet-activating factor (PAF) markedly enhances responses to chemotactic peptides (such as n-formyl-met-leu-phe, FMLP) and phorbol esters (such as phorbol myristate acetate, PMA) in human neutrophils.	Tetradecanoylphorbol Acetate	220-245	PCNA clamp associated factor	Homo sapiens	98-101
8391006-1	1993	Although a weak direct stimulus of superoxide anion (O2-) production, platelet-activating factor (PAF) markedly enhances responses to chemotactic peptides (such as n-formyl-met-leu-phe, FMLP) and phorbol esters (such as phorbol myristate acetate, PMA) in human neutrophils.	Tetradecanoylphorbol Acetate	247-250	PCNA clamp associated factor	Homo sapiens	70-96
8391006-1	1993	Although a weak direct stimulus of superoxide anion (O2-) production, platelet-activating factor (PAF) markedly enhances responses to chemotactic peptides (such as n-formyl-met-leu-phe, FMLP) and phorbol esters (such as phorbol myristate acetate, PMA) in human neutrophils.	Tetradecanoylphorbol Acetate	247-250	PCNA clamp associated factor	Homo sapiens	98-101
8323980-4	1993	The phorbol ester, 12-O-tetradeconoylphorbol 13-acetate (TPA), cannot support growth of these cells, is a more effective inducer than insulin of c-fos, c-myc, c-jun, jun-B, Krox-20, Krox 24, fra-1 and JE, and induces fra-1, JE and c-myc with different kinetics from those of insulin.	Tetradecanoylphorbol Acetate	57-60	transcription factor jun-B	Cricetulus griseus	166-171
8405374-4	1993	TPA-treated cells showed binding for C3b and weak binding for C3 and C3d.	Tetradecanoylphorbol Acetate	0-3	endogenous retrovirus group K member 13	Homo sapiens	69-72
8405374-5	1993	Taken together, the data suggest that Raji cells may express three binding sites for C3, C3b and C3d which can be differently modulated by anti-CR2 MoAbs and TPA.	Tetradecanoylphorbol Acetate	158-161	endogenous retrovirus group K member 13	Homo sapiens	97-100
8390537-5	1993	Notably, acidification or treatment with primary amines selectively inhibited the response to TNF, compared with the response to PMA, a drug that induces ELAM-1 through a pathway that bypasses surface receptors.	Tetradecanoylphorbol Acetate	129-132	selectin E	Homo sapiens	154-160
8388736-2	1993	Enhanced phosphorylation of eIF-4B was also detected upon exposure of the cells to phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), suggesting that eIF-4B may be a substrate of PKC.	Tetradecanoylphorbol Acetate	83-114	eukaryotic translation initiation factor 4B	Homo sapiens	28-34
8388736-2	1993	Enhanced phosphorylation of eIF-4B was also detected upon exposure of the cells to phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), suggesting that eIF-4B may be a substrate of PKC.	Tetradecanoylphorbol Acetate	83-114	eukaryotic translation initiation factor 4B	Homo sapiens	178-184
8388736-2	1993	Enhanced phosphorylation of eIF-4B was also detected upon exposure of the cells to phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), suggesting that eIF-4B may be a substrate of PKC.	Tetradecanoylphorbol Acetate	116-119	eukaryotic translation initiation factor 4B	Homo sapiens	28-34
8388736-2	1993	Enhanced phosphorylation of eIF-4B was also detected upon exposure of the cells to phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), suggesting that eIF-4B may be a substrate of PKC.	Tetradecanoylphorbol Acetate	116-119	eukaryotic translation initiation factor 4B	Homo sapiens	178-184
8505299-14	1993	Treatment of the cells with 100 nM 12-O-tetradecanoylphorbol-13-acetate resulted in a 20 +/- 1.2% (mean +/- S.E., p &lt; 0.01, n = 4) increase in the PLA2 activity in the cytosol but failed to increase PLA2 activity in the particulate fraction.	Tetradecanoylphorbol Acetate	35-71	LOC104974671	Bos taurus	202-206
8099849-7	1993	When CD26+ T cells were cultured in the presence of PMA, which depletes pkC activity, CD26 antigen expression was down-regulated.	Tetradecanoylphorbol Acetate	52-55	dipeptidyl peptidase 4	Homo sapiens	5-9
8099849-7	1993	When CD26+ T cells were cultured in the presence of PMA, which depletes pkC activity, CD26 antigen expression was down-regulated.	Tetradecanoylphorbol Acetate	52-55	dipeptidyl peptidase 4	Homo sapiens	86-90
8099851-2	1993	Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	171-196	interleukin 1 alpha	Homo sapiens	18-31
8099851-2	1993	Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	198-201	interleukin 1 alpha	Homo sapiens	18-31
8504741-6	1993	Thus, since extended exposure to TPA can down-regulate PKC, suppression of GnRH mRNA by TPA may be due to decreased PKC activity, indicating a role for PKC in the maintenance of the GnRH gene expression (a role that is unlikely to involve c-fos).	Tetradecanoylphorbol Acetate	33-36	gonadotropin releasing hormone 1	Mus musculus	182-186
8504741-6	1993	Thus, since extended exposure to TPA can down-regulate PKC, suppression of GnRH mRNA by TPA may be due to decreased PKC activity, indicating a role for PKC in the maintenance of the GnRH gene expression (a role that is unlikely to involve c-fos).	Tetradecanoylphorbol Acetate	88-91	gonadotropin releasing hormone 1	Mus musculus	75-79
8504741-6	1993	Thus, since extended exposure to TPA can down-regulate PKC, suppression of GnRH mRNA by TPA may be due to decreased PKC activity, indicating a role for PKC in the maintenance of the GnRH gene expression (a role that is unlikely to involve c-fos).	Tetradecanoylphorbol Acetate	88-91	gonadotropin releasing hormone 1	Mus musculus	182-186
8504741-7	1993	In transient transfections, the transcriptional activity from 3 kilobases of GnRH 5"-flanking sequence was repressed 2-fold by either 100 nM TPA or 20 microM NPC 15437 at 24 h, demonstrating that suppression of GnRH mRNA is at least, in part, at the level of transcription.	Tetradecanoylphorbol Acetate	141-144	gonadotropin releasing hormone 1	Mus musculus	77-81
8504741-7	1993	In transient transfections, the transcriptional activity from 3 kilobases of GnRH 5"-flanking sequence was repressed 2-fold by either 100 nM TPA or 20 microM NPC 15437 at 24 h, demonstrating that suppression of GnRH mRNA is at least, in part, at the level of transcription.	Tetradecanoylphorbol Acetate	141-144	gonadotropin releasing hormone 1	Mus musculus	211-215
8504741-9	1993	Enhancement of GnRH secretion by TPA was robust and rapid (2.5 min), while the response to forskolin was relatively delayed (2 h).	Tetradecanoylphorbol Acetate	33-36	gonadotropin releasing hormone 1	Mus musculus	15-19
8500530-1	1993	The effect of phorbol 12-myristate 13-acetate (PMA) on the synthesis, assembly and processing of the components of the T cell receptor (TcR) was studied with special focus on the CD3 omega chain.	Tetradecanoylphorbol Acetate	14-45	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	119-134
8500530-1	1993	The effect of phorbol 12-myristate 13-acetate (PMA) on the synthesis, assembly and processing of the components of the T cell receptor (TcR) was studied with special focus on the CD3 omega chain.	Tetradecanoylphorbol Acetate	14-45	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	136-139
8500530-1	1993	The effect of phorbol 12-myristate 13-acetate (PMA) on the synthesis, assembly and processing of the components of the T cell receptor (TcR) was studied with special focus on the CD3 omega chain.	Tetradecanoylphorbol Acetate	47-50	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	119-134
8500530-1	1993	The effect of phorbol 12-myristate 13-acetate (PMA) on the synthesis, assembly and processing of the components of the T cell receptor (TcR) was studied with special focus on the CD3 omega chain.	Tetradecanoylphorbol Acetate	47-50	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	136-139
8500530-6	1993	However, for all cell lines studied the amount of TcR complexes expressed on the cell surface was decreased after 16 h of PMA treatment.	Tetradecanoylphorbol Acetate	122-125	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	50-53
8359866-1	1993	CD8 (Ly-2) expression was suppressed in purified murine CD4-CD8+ thymocytes at the mRNA level upon continuous stimulation with PMA and ionomycin in the presence of rIL-2.	Tetradecanoylphorbol Acetate	127-130	interleukin 2	Rattus norvegicus	164-169
8396623-8	1993	TPA, although it decreased IGF-II mRNA levels, tended to increase IGF-II peptide in the medium.	Tetradecanoylphorbol Acetate	0-3	insulin like growth factor 2	Homo sapiens	66-72
8395652-6	1993	Activation of protein kinase C with the phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate decreased TRHR mRNA by about 40% in 4 h. Elevation of [Ca2+]i with ionomycin decreased TRHR mRNA by about 25%.	Tetradecanoylphorbol Acetate	54-91	thyrotropin releasing hormone receptor	Rattus norvegicus	102-106
8395652-6	1993	Activation of protein kinase C with the phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate decreased TRHR mRNA by about 40% in 4 h. Elevation of [Ca2+]i with ionomycin decreased TRHR mRNA by about 25%.	Tetradecanoylphorbol Acetate	54-91	thyrotropin releasing hormone receptor	Rattus norvegicus	179-183
8426742-8	1993	The serum induction of c-fos and junD as well as the serum and TPA (12-O-tetradecanoylphorbol-13-acetate) induction of junB and egr-1 are almost completely abolished.	Tetradecanoylphorbol Acetate	63-66	jun B proto-oncogene	Mus musculus	119-123
8426742-8	1993	The serum induction of c-fos and junD as well as the serum and TPA (12-O-tetradecanoylphorbol-13-acetate) induction of junB and egr-1 are almost completely abolished.	Tetradecanoylphorbol Acetate	63-66	early growth response 1	Mus musculus	128-133
8426742-8	1993	The serum induction of c-fos and junD as well as the serum and TPA (12-O-tetradecanoylphorbol-13-acetate) induction of junB and egr-1 are almost completely abolished.	Tetradecanoylphorbol Acetate	68-104	jun B proto-oncogene	Mus musculus	119-123
8426742-8	1993	The serum induction of c-fos and junD as well as the serum and TPA (12-O-tetradecanoylphorbol-13-acetate) induction of junB and egr-1 are almost completely abolished.	Tetradecanoylphorbol Acetate	68-104	early growth response 1	Mus musculus	128-133
8485613-7	1993	Both of the biphasic actions of GnRH on aromatase response to FSH were mimicked by protein kinase C activators, phobol myristate acetate (PMA) and oleoylacetyl glycerol; maximal effects occurred at 1 to 10 ng/mL.	Tetradecanoylphorbol Acetate	138-141	gonadotropin releasing hormone 1	Rattus norvegicus	32-36
8435107-3	1993	Northern analysis of mRNA isolated from the dorsal skins of SENCAR mice treated with 1 microgram of 4 beta-12-O-tetradecanoylphorbol-13-acetate (TPA) showed that a single application of TPA produced a significant increase in IL-1 alpha mRNA at 6 h that decreased by 24 h after treatment.	Tetradecanoylphorbol Acetate	186-189	interleukin 1 alpha	Mus musculus	225-235
8435107-4	1993	Two treatments of TPA at 48-h intervals induced, at 6 h, twice as much IL-1 alpha mRNA as one treatment.	Tetradecanoylphorbol Acetate	18-21	interleukin 1 alpha	Mus musculus	71-81
8435107-7	1993	The effects of various antitumor promoters on TPA-induced IL-1 alpha mRNA expression were also assessed.	Tetradecanoylphorbol Acetate	46-49	interleukin 1 alpha	Mus musculus	58-68
8424125-6	1993	Like 12-O-Tetradecanoly phorbol-13-acetate (TPA), a PK-C activator which also enhances EGF-stimulated growth of MEC, linoleate can phosphorylate a 40-42 KD protein.	Tetradecanoylphorbol Acetate	44-47	epidermal growth factor	Homo sapiens	87-90
8342330-4	1993	Addition of PMA (&gt; or = 10 nM) to monolayer cell cultures induced a 2- to 5.5-fold increase of PAI-1 antigen production within 8-24 h. In HUVEC, PMA (160 nM) induced both the 2.4 kb and 3.4 kb mRNA species of PAI-1: 3.1 +/- 1.1 and 1.7 +/- 0.8-fold (n = 6), respectively, within 8 h. Run-on experiments confirmed that this increase is at least partially mediated by increased gene transcription.	Tetradecanoylphorbol Acetate	12-15	serpin family E member 1	Homo sapiens	98-103
8342330-4	1993	Addition of PMA (&gt; or = 10 nM) to monolayer cell cultures induced a 2- to 5.5-fold increase of PAI-1 antigen production within 8-24 h. In HUVEC, PMA (160 nM) induced both the 2.4 kb and 3.4 kb mRNA species of PAI-1: 3.1 +/- 1.1 and 1.7 +/- 0.8-fold (n = 6), respectively, within 8 h. Run-on experiments confirmed that this increase is at least partially mediated by increased gene transcription.	Tetradecanoylphorbol Acetate	12-15	serpin family E member 1	Homo sapiens	212-217
8342330-4	1993	Addition of PMA (&gt; or = 10 nM) to monolayer cell cultures induced a 2- to 5.5-fold increase of PAI-1 antigen production within 8-24 h. In HUVEC, PMA (160 nM) induced both the 2.4 kb and 3.4 kb mRNA species of PAI-1: 3.1 +/- 1.1 and 1.7 +/- 0.8-fold (n = 6), respectively, within 8 h. Run-on experiments confirmed that this increase is at least partially mediated by increased gene transcription.	Tetradecanoylphorbol Acetate	148-151	serpin family E member 1	Homo sapiens	98-103
8342330-4	1993	Addition of PMA (&gt; or = 10 nM) to monolayer cell cultures induced a 2- to 5.5-fold increase of PAI-1 antigen production within 8-24 h. In HUVEC, PMA (160 nM) induced both the 2.4 kb and 3.4 kb mRNA species of PAI-1: 3.1 +/- 1.1 and 1.7 +/- 0.8-fold (n = 6), respectively, within 8 h. Run-on experiments confirmed that this increase is at least partially mediated by increased gene transcription.	Tetradecanoylphorbol Acetate	148-151	serpin family E member 1	Homo sapiens	212-217
8342330-5	1993	When HUVEC, HT1080 and HeLa, transfected with an 826 bp or a 336 bp PAI-1 gene promoter fragment, were stimulated with 160 nM phorbol 12-myristate 13-acetate (PMA), the CAT activity was induced 4-, 3.5- and 10-fold respectively for both constructs, revealing that PMA responsive sequences are present in the proximal 336 bp of the PAI-1 promoter.	Tetradecanoylphorbol Acetate	126-157	serpin family E member 1	Homo sapiens	68-73
8497248-7	1993	c-fms mRNA is acutely down-regulated in primary macrophages by CSF-1, bacterial lipopolysaccharide (LPS), and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	110-135	colony stimulating factor 1 receptor	Mus musculus	0-5
8497248-7	1993	c-fms mRNA is acutely down-regulated in primary macrophages by CSF-1, bacterial lipopolysaccharide (LPS), and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	137-140	colony stimulating factor 1 receptor	Mus musculus	0-5
15711926-7	2005	The increase in the percentage of spermatozoa Annexin V-FITC-positive/ PI-negative (early event of late apoptosis) was significant after the incubation with PMN plus PMA, PMN plus E. coli and E. coli alone.	Tetradecanoylphorbol Acetate	166-169	annexin A5	Homo sapiens	46-55
8388378-2	1993	We observed that the expression of the spr1 gene is strongly induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	72-103	psoriasis susceptibility 1 candidate 2	Homo sapiens	39-43
8388378-2	1993	We observed that the expression of the spr1 gene is strongly induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	105-108	psoriasis susceptibility 1 candidate 2	Homo sapiens	39-43
8322268-8	1993	With such high PAI-Fx available to bind tPA, occlusion-stimulated tPA-Fx could not rise, and fibrinolysis could not be initiated.	Tetradecanoylphorbol Acetate	40-43	serpin family B member 2	Homo sapiens	15-18
8342330-5	1993	When HUVEC, HT1080 and HeLa, transfected with an 826 bp or a 336 bp PAI-1 gene promoter fragment, were stimulated with 160 nM phorbol 12-myristate 13-acetate (PMA), the CAT activity was induced 4-, 3.5- and 10-fold respectively for both constructs, revealing that PMA responsive sequences are present in the proximal 336 bp of the PAI-1 promoter.	Tetradecanoylphorbol Acetate	126-157	serpin family E member 1	Homo sapiens	331-336
8342330-5	1993	When HUVEC, HT1080 and HeLa, transfected with an 826 bp or a 336 bp PAI-1 gene promoter fragment, were stimulated with 160 nM phorbol 12-myristate 13-acetate (PMA), the CAT activity was induced 4-, 3.5- and 10-fold respectively for both constructs, revealing that PMA responsive sequences are present in the proximal 336 bp of the PAI-1 promoter.	Tetradecanoylphorbol Acetate	159-162	serpin family E member 1	Homo sapiens	68-73
8485117-6	1993	Phorbol ester (phorbol 12-myristate 13-acetate, 160 nM) treatment of CHRF-288 and HEL cells for 4 days induced PAI-1 mRNA expression in CHRF-288 cells but not in HEL cells.	Tetradecanoylphorbol Acetate	15-46	serpin family E member 1	Homo sapiens	111-116
15547925-5	2005	As a result of major bleeding, the fibrinolytic system was also activated: a biphasic elevation of tPA was seen, first immediately after the bleeding event at 2 h, and later on the first postoperative day, followed by fibrinolytic shutdown associated with increased PAI-1 values.	Tetradecanoylphorbol Acetate	99-102	serpin family E member 1	Homo sapiens	266-271
8518229-2	1993	Expression of the endogenous c-myc gene has now been monitored during the differentiation, and associated loss of proliferation, of ML-1 human myeloblastic leukemia cells: c-myc mRNA remains detectable, at decreased levels, during differentiation along the monocyte/macrophage pathway induced with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	298-334	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	29-34
8518229-6	1993	These findings suggest that, during the 12-O-tetradecanoylphorbol-13-acetate-induced differentiation and loss of proliferation of ML-1 cells, c-myc protein is regulated through alterations that affect its cytoplasmic/nuclear distribution rather than its total cellular content.	Tetradecanoylphorbol Acetate	40-76	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	142-147
8504805-2	1993	Treatment with okadaic acid caused rapid phosphorylation of five proteins with molecular masses of 65, 55, 50, 28 and 15 kDa (p65, p55, p50, p28, p15, respectively) while TPA caused rapid phosphorylation of five proteins with molecular masses of 80, 70, 40, 34 and 28 kDa (p80, p70, p40, p34, p28, respectively).	Tetradecanoylphorbol Acetate	171-174	coilin	Mus musculus	273-276
15458367-1	2005	Protein kinase C (PKC), a family of phospholipid-dependent serine/threonine kinases, is not only the major intracellular receptor for the mouse skin tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) but also is activated by a variety of stress factors including ultraviolet radiation (UVR).	Tetradecanoylphorbol Acetate	164-200	protein kinase C epsilon	Homo sapiens	18-21
8513862-2	1993	Treatment of PEM with lipopolysaccharide (LPS) or tumor-promoting phorbol ester (12-O-tetradecanoylphorbol-13-acetate [TPA]) induces a rapid but transient loss of M-CSF receptors in PEM.	Tetradecanoylphorbol Acetate	81-117	colony stimulating factor 1	Homo sapiens	163-168
15458367-1	2005	Protein kinase C (PKC), a family of phospholipid-dependent serine/threonine kinases, is not only the major intracellular receptor for the mouse skin tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) but also is activated by a variety of stress factors including ultraviolet radiation (UVR).	Tetradecanoylphorbol Acetate	202-205	protein kinase C epsilon	Homo sapiens	18-21
8513862-2	1993	Treatment of PEM with lipopolysaccharide (LPS) or tumor-promoting phorbol ester (12-O-tetradecanoylphorbol-13-acetate [TPA]) induces a rapid but transient loss of M-CSF receptors in PEM.	Tetradecanoylphorbol Acetate	119-122	colony stimulating factor 1	Homo sapiens	163-168
15803435-7	2004	Phorbol-myristate-acetate, known to stimulate release of AA and MCSF, was used as a positive control in both experiments.	Tetradecanoylphorbol Acetate	0-25	colony stimulating factor 1	Homo sapiens	64-68
8513862-5	1993	On the other hand, the loss of M-CSF receptors induced by TPA has been prevented by PKC inhibitors but not by PLC inhibitors.	Tetradecanoylphorbol Acetate	58-61	colony stimulating factor 1	Homo sapiens	31-36
8513862-8	1993	Our results show that 1) TPA-induced M-CSF receptor loss is strictly dependent on PKC activation; 2) PLC activation alone also leads to downregulation of M-CSF receptors; and 3) LPS-induced M-CSF receptor downregulation in PEM is mediated primarily through a PLC-dependent pathway.	Tetradecanoylphorbol Acetate	25-28	colony stimulating factor 1	Homo sapiens	37-42
8513862-8	1993	Our results show that 1) TPA-induced M-CSF receptor loss is strictly dependent on PKC activation; 2) PLC activation alone also leads to downregulation of M-CSF receptors; and 3) LPS-induced M-CSF receptor downregulation in PEM is mediated primarily through a PLC-dependent pathway.	Tetradecanoylphorbol Acetate	25-28	colony stimulating factor 1	Homo sapiens	154-159
8513862-8	1993	Our results show that 1) TPA-induced M-CSF receptor loss is strictly dependent on PKC activation; 2) PLC activation alone also leads to downregulation of M-CSF receptors; and 3) LPS-induced M-CSF receptor downregulation in PEM is mediated primarily through a PLC-dependent pathway.	Tetradecanoylphorbol Acetate	25-28	colony stimulating factor 1	Homo sapiens	154-159
15558242-2	2004	Treatment with chymotrypsin or phorbol 12-myristate 13-acetate to shedding of L: -selectin had no effect on subsequent kazinol B-induced Ca(2+) response.	Tetradecanoylphorbol Acetate	31-62	selectin L	Homo sapiens	78-90
8491554-3	1993	RESULTS: Data indicate that messenger RNA levels for plasminogen activator inhibitor-1 are modulated in similar fashion in both cells types, being increased by incubation with transforming growth factor-beta, dexamethasone, tumor necrosis factor, phorbol myristate acetate, and thrombin.	Tetradecanoylphorbol Acetate	247-272	serpin family E member 1	Homo sapiens	53-86
8360272-4	1993	Beta 1 integrins were diffused on the adhesion surface, while alpha v beta 3 was clustered in focal contacts both in control cells and upon dendrite induction with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	164-195	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	70-76
8360272-4	1993	Beta 1 integrins were diffused on the adhesion surface, while alpha v beta 3 was clustered in focal contacts both in control cells and upon dendrite induction with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	197-200	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	70-76
19379296-7	2004	In both cell lines, stimulation with the tumour promoter phorbol 12-myristate 13-acetate induced a time-dependent increase in COX-2 protein, with COX-2 induction being stronger in cancerous SCC than in normal CK cells.	Tetradecanoylphorbol Acetate	57-88	prostaglandin-endoperoxide synthase 2	Canis lupus familiaris	126-131
7685642-0	1993	Involvement of the carboxyl-terminal region in modulation by TPA of the NMDA receptor channel.	Tetradecanoylphorbol Acetate	61-64	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	72-85
7685642-3	1993	To identify the structural domain involved in the modulation of the NMDA receptor channel by the TPA treatment, we constructed chimeric subunits between the epsilon 2 and epsilon 3 subunits.	Tetradecanoylphorbol Acetate	97-100	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	68-81
19379296-7	2004	In both cell lines, stimulation with the tumour promoter phorbol 12-myristate 13-acetate induced a time-dependent increase in COX-2 protein, with COX-2 induction being stronger in cancerous SCC than in normal CK cells.	Tetradecanoylphorbol Acetate	57-88	prostaglandin-endoperoxide synthase 2	Canis lupus familiaris	146-151
8484776-3	1993	The TPA-induced monocyte chemotactic protein-1 expression was abolished by treating the cells with both staurosporine and genistein; however, only a portion of the LPS-induced expression was inhibited by staurosporine/genistein.	Tetradecanoylphorbol Acetate	4-7	C-C motif chemokine ligand 2	Homo sapiens	16-46
8476858-2	1993	Our results show that differentiation of U937 cells with exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA) induces a temporally delayed (16-24 h) but marked increase in the biosynthesis and secretion of interstitial collagenase and TIMP.	Tetradecanoylphorbol Acetate	69-105	matrix metallopeptidase 1	Homo sapiens	208-232
15494373-2	2004	We found that heterogeneous nuclear ribonucleoprotein C1 and C2 (hnRNP C1/C2), two nuclear restricted pre-mRNA binding proteins, are translocated to the cytosolic compartment in a ROCK-dependent manner in PMA-induced pro-apoptotic cells, where nuclear envelopes remain intact.	Tetradecanoylphorbol Acetate	205-208	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	14-63
8476858-2	1993	Our results show that differentiation of U937 cells with exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA) induces a temporally delayed (16-24 h) but marked increase in the biosynthesis and secretion of interstitial collagenase and TIMP.	Tetradecanoylphorbol Acetate	107-110	matrix metallopeptidase 1	Homo sapiens	208-232
8470912-10	1993	Furthermore, the cross-talk between RAR and AP-1 is thought to give an explanation for the suppressive effects of retinoids against tumor promoters (TPA and others).	Tetradecanoylphorbol Acetate	149-152	retinoic acid receptor alpha	Homo sapiens	36-39
15494373-2	2004	We found that heterogeneous nuclear ribonucleoprotein C1 and C2 (hnRNP C1/C2), two nuclear restricted pre-mRNA binding proteins, are translocated to the cytosolic compartment in a ROCK-dependent manner in PMA-induced pro-apoptotic cells, where nuclear envelopes remain intact.	Tetradecanoylphorbol Acetate	205-208	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	65-76
15479821-2	2004	In this study, we found that TPA up-regulated phosphorylation of p38, a mitogen-activated protein kinase, and activated c-myc mRNA in EBV-positive epithelial GT38 cells.	Tetradecanoylphorbol Acetate	29-32	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	120-125
15479821-3	2004	The EBV immediate-early gene BZLF1 mRNA and its product ZEBRA protein were induced following TPA treatment.	Tetradecanoylphorbol Acetate	93-96	protein Zta	Human gammaherpesvirus 4	29-34
8469926-7	1993	The rIFN-gamma-activated macrophages displayed enhanced O2-consumption after stimulation with phorbol myristate acetate and heat-killed Listeria compared with macrophages from normal mice.	Tetradecanoylphorbol Acetate	94-119	interferon gamma	Rattus norvegicus	4-14
15479821-6	2004	Pretreatment of GT38 cells with the nitric oxide (NO) donor S-nitroso-N-acetylpenicillamine inhibited p38 phosphorylation and c-Myc activation by TPA, suggesting that NO may inhibit EBV reactivation via both p38 and c-Myc.	Tetradecanoylphorbol Acetate	146-149	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	126-131
15479821-9	2004	Our present study demonstrates for the first time that either p38 or c-myc siRNA can efficiently inhibit TPA-induced EBV reactivation in GT38 cells, indicating that p38- and/or c-myc-associated signaling pathways may play critical roles in the disruption of EBV latency by TPA.	Tetradecanoylphorbol Acetate	105-108	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	69-74
15542774-6	2004	Activation of PKC by phorbol ester (phorbol 12-myristate 13-acetate) enhanced EGF action on ERK1/2 phosphorylation without significantly altering p53 phosphorylation by resveratrol.	Tetradecanoylphorbol Acetate	36-67	epidermal growth factor	Homo sapiens	78-81
8454603-2	1993	We have investigated the molecular and biochemical basis for activation of interleukin 3 (IL3) gene expression in primary human T lymphocytes following CD3 and CD2 receptor stimulation or activation by phytohemagglutinin plus phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	226-257	interleukin 3	Homo sapiens	75-88
8454603-2	1993	We have investigated the molecular and biochemical basis for activation of interleukin 3 (IL3) gene expression in primary human T lymphocytes following CD3 and CD2 receptor stimulation or activation by phytohemagglutinin plus phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	226-257	interleukin 3	Homo sapiens	90-93
8454603-5	1993	The data also indicate that CD2 receptor activation and phytohemagglutinin plus phorbol 12-myristate 13-acetate stimulation augment T cell IL3 gene expression through the same cis- and trans-activating signals.	Tetradecanoylphorbol Acetate	80-111	interleukin 3	Homo sapiens	139-142
8449916-1	1993	The tumor promoter phorbol myristate acetate (PMA) directly activates protein kinase C (PKC) and, in human platelets, induces aggregation, release of granular contents, mobilization of intracellular Ca2+ as detected by the photoprotein aequorin, and phosphorylation of the 47-kDa substrate (p47) of PKC.	Tetradecanoylphorbol Acetate	19-44	pleckstrin	Homo sapiens	291-294
8449916-1	1993	The tumor promoter phorbol myristate acetate (PMA) directly activates protein kinase C (PKC) and, in human platelets, induces aggregation, release of granular contents, mobilization of intracellular Ca2+ as detected by the photoprotein aequorin, and phosphorylation of the 47-kDa substrate (p47) of PKC.	Tetradecanoylphorbol Acetate	46-49	pleckstrin	Homo sapiens	291-294
15470039-4	2004	For NK1/NK2 cell differentiation, initial stimulation with PMA and ionomycin was required.	Tetradecanoylphorbol Acetate	59-62	tachykinin 1	Mus musculus	4-7
8096323-12	1993	A PKC inhibitor, 1-(5-isoquinolinyl-sulfonyl)-2-methyl piperazine (H-7), blocked the PMA-dependent attenuation of ANF-dependent cyclic GMP formation.	Tetradecanoylphorbol Acetate	85-88	natriuretic peptide A	Bos taurus	114-117
15355467-8	2004	Nonspecific stimulus with calcium ionophore and phorbol-myristate-acetate of BM CD34(+) cells caused release of IL-5, IL-3 and GM-CSF.	Tetradecanoylphorbol Acetate	48-73	CD34 antigen	Mus musculus	80-84
7681664-0	1993	Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C. Treatment of murine hepatoma 1c1c7 cultures with dibenz[a,c]anthracene (DB[a,c]A)-induced P450 Cyp1a-1, as indicated by analyses of CYP1A1 mRNA and 7-ethoxyresorufin O-deethylase (EROD) activity.	Tetradecanoylphorbol Acetate	83-119	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	31-38
15355467-8	2004	Nonspecific stimulus with calcium ionophore and phorbol-myristate-acetate of BM CD34(+) cells caused release of IL-5, IL-3 and GM-CSF.	Tetradecanoylphorbol Acetate	48-73	interleukin 5	Mus musculus	112-116
8466854-4	1993	The effects of TPA on expression of cell cycle control genes demonstrated down-regulation of the cdc25 mitotic inducer during S-G2 progression.	Tetradecanoylphorbol Acetate	15-18	cell division cycle 25C	Homo sapiens	97-102
15493875-2	2004	In addition to inhibiting serine proteases (mainly tPA and uPA), PAI-1 interacts with vitronectin (Vn), fibrin or alpha(1)-acid glycoprotein, interactions which are important for PAI-1-mediated effects in inflammation, tumor invasion and metastasis.	Tetradecanoylphorbol Acetate	51-54	serpin family E member 1	Homo sapiens	65-70
8466854-8	1993	Taken together, these results indicate that the cdc25 gene product is functionally associated with S-G2 transition of proliferating myeloid leukemia cells and that down-regulation of this gene by TPA is associated with G2-M delay.	Tetradecanoylphorbol Acetate	196-199	cell division cycle 25C	Homo sapiens	48-53
15306223-6	2004	Pretreatment of tissues with PMA caused a marked reduction in the inotropic effect of hU-II, but did not affect hU-II-mediated phosphorylation of MLC-2.	Tetradecanoylphorbol Acetate	29-32	urotensin 2	Homo sapiens	86-91
15178807-0	2004	The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) provokes a prolonged morphologic response and ERK activation in Tsc2-null renal tumor cells.	Tetradecanoylphorbol Acetate	19-55	TSC complex subunit 2	Rattus norvegicus	126-130
15178807-0	2004	The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) provokes a prolonged morphologic response and ERK activation in Tsc2-null renal tumor cells.	Tetradecanoylphorbol Acetate	57-60	TSC complex subunit 2	Rattus norvegicus	126-130
15178807-4	2004	The tumor suppressor protein Tsc2 has a proposed GTPase activating protein (GAP) function for Rap1, providing a common mechanistic target for Tsc2 and TPA.	Tetradecanoylphorbol Acetate	151-154	TSC complex subunit 2	Rattus norvegicus	29-33
15178807-5	2004	We compared the cellular response of Tsc2-null (ERC-18) and Tsc2-competent (NRK-52E) renal epithelial cells to TPA treatment.	Tetradecanoylphorbol Acetate	111-114	TSC complex subunit 2	Rattus norvegicus	60-64
15334481-4	2004	METHODS: The shedding of TNFRSF1A in response to stimulation with phorbol myristate acetate was assessed in leukocytes and dermal fibroblasts from patients with C33Y TRAPS, and in HEK 293 cell lines stably transfected with constructs containing wild-type TNFRSF1A and/or TNFRSF1A mutants identified in TRAPS patients.	Tetradecanoylphorbol Acetate	66-91	TNF receptor superfamily member 1A	Homo sapiens	25-33
15334481-4	2004	METHODS: The shedding of TNFRSF1A in response to stimulation with phorbol myristate acetate was assessed in leukocytes and dermal fibroblasts from patients with C33Y TRAPS, and in HEK 293 cell lines stably transfected with constructs containing wild-type TNFRSF1A and/or TNFRSF1A mutants identified in TRAPS patients.	Tetradecanoylphorbol Acetate	66-91	TNF receptor superfamily member 1A	Homo sapiens	255-263
15334481-4	2004	METHODS: The shedding of TNFRSF1A in response to stimulation with phorbol myristate acetate was assessed in leukocytes and dermal fibroblasts from patients with C33Y TRAPS, and in HEK 293 cell lines stably transfected with constructs containing wild-type TNFRSF1A and/or TNFRSF1A mutants identified in TRAPS patients.	Tetradecanoylphorbol Acetate	66-91	TNF receptor superfamily member 1A	Homo sapiens	255-263
15279563-9	2004	MAO B, but not MAO A gene, could be activated by PMA (phorbol 12-myristate 13-acetate) by protein kinase C, MAPkinase signal transduction pathway involves cJun and Egr-1.	Tetradecanoylphorbol Acetate	54-85	early growth response 1	Homo sapiens	164-169
15246828-8	2004	In tPA-treated rabbits (0.9 mg/kg), the group P50 was 1.58 +/- 0.43 mg.	Tetradecanoylphorbol Acetate	3-6	Y-box-binding protein 1	Oryctolagus cuniculus	46-49
15246828-9	2004	In caffeinol (bolus) and tPA-treated rabbits, we measured a decrease in the P50 value to 0.70 +/- 0.30 mg and an increase in the rate of intracerebral hemorrhage compared to control.	Tetradecanoylphorbol Acetate	25-28	Y-box-binding protein 1	Oryctolagus cuniculus	76-79
15254761-7	2004	LSM showed that HOE642 prevented the PMA-induced disassociation of the zonula adherens molecule beta-catenin from the cell membrane and the decreased expression of the zonula occludens molecule ZO-1.	Tetradecanoylphorbol Acetate	37-40	catenin beta 1	Homo sapiens	96-108
15064333-4	2004	In mouse crude striatal and hippocampal synaptosomes, PKC activators beta-phorbol 12-myristate 13-acetate (beta-PMA) and beta-phorbol 12,13-dibutyrate produced time- and concentration-dependent reductions in CHT function.	Tetradecanoylphorbol Acetate	69-105	solute carrier family 5 (choline transporter), member 7	Mus musculus	208-211
15064333-4	2004	In mouse crude striatal and hippocampal synaptosomes, PKC activators beta-phorbol 12-myristate 13-acetate (beta-PMA) and beta-phorbol 12,13-dibutyrate produced time- and concentration-dependent reductions in CHT function.	Tetradecanoylphorbol Acetate	107-115	solute carrier family 5 (choline transporter), member 7	Mus musculus	208-211
15464363-3	2004	It contains a functionally active AP-1 site (TPA Responsive Element, TRE) which is essential for the high transcriptional activity of the COL10A1 enhancer in transiently transfected hypertrophic chondrocytes.	Tetradecanoylphorbol Acetate	45-48	collagen type X alpha 1 chain	Homo sapiens	138-145
15117942-6	2004	Furthermore, we found that treatment with both ionomycin and phorbol 12-myristate 13-acetate ensured efficient nuclear anchorage with the recruitment of NFAT1 into the SUMO-1 bodies, whereas treatment with ionomycin alone induced nuclear translocation of NFAT1 but not recruitment into the SUMO-1 bodies.	Tetradecanoylphorbol Acetate	61-92	nuclear factor of activated T cells 2	Homo sapiens	153-158
15117942-6	2004	Furthermore, we found that treatment with both ionomycin and phorbol 12-myristate 13-acetate ensured efficient nuclear anchorage with the recruitment of NFAT1 into the SUMO-1 bodies, whereas treatment with ionomycin alone induced nuclear translocation of NFAT1 but not recruitment into the SUMO-1 bodies.	Tetradecanoylphorbol Acetate	61-92	nuclear factor of activated T cells 2	Homo sapiens	255-260
15117942-7	2004	Our results suggest that the recruitment of NFAT1 into SUMO-1 bodies may be required for the progressive transcriptional activity of NFAT1 upon co-stimulation with ionomycin and phorbol 12-myristate 13-acetate, whereas anergic transcription stimulated by ionomycin alone may occur without recruitment into the SUMO-1 bodies.	Tetradecanoylphorbol Acetate	178-209	nuclear factor of activated T cells 2	Homo sapiens	44-49
15117942-7	2004	Our results suggest that the recruitment of NFAT1 into SUMO-1 bodies may be required for the progressive transcriptional activity of NFAT1 upon co-stimulation with ionomycin and phorbol 12-myristate 13-acetate, whereas anergic transcription stimulated by ionomycin alone may occur without recruitment into the SUMO-1 bodies.	Tetradecanoylphorbol Acetate	178-209	nuclear factor of activated T cells 2	Homo sapiens	133-138
15228600-2	2004	When COS-7 cells transfected with AANAT cDNA were treated with phorbol 12-myristate 13-acetate (PMA), both the activity and protein level of AANAT were increased.	Tetradecanoylphorbol Acetate	96-99	aralkylamine N-acetyltransferase	Rattus norvegicus	34-39
15228600-2	2004	When COS-7 cells transfected with AANAT cDNA were treated with phorbol 12-myristate 13-acetate (PMA), both the activity and protein level of AANAT were increased.	Tetradecanoylphorbol Acetate	96-99	aralkylamine N-acetyltransferase	Rattus norvegicus	141-146
15122342-6	2004	We first determined the effect of topical application of Lupeol to CD-1 mouse against 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced conventional markers and other novel markers of skin tumor promotion.	Tetradecanoylphorbol Acetate	86-123	CD1 antigen complex	Mus musculus	67-71
15122342-6	2004	We first determined the effect of topical application of Lupeol to CD-1 mouse against 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced conventional markers and other novel markers of skin tumor promotion.	Tetradecanoylphorbol Acetate	125-128	CD1 antigen complex	Mus musculus	67-71
15122342-7	2004	We found that topical application of Lupeol (1-2 mg/mouse) 30 min prior to TPA (3.2 nmol/mouse) application onto the skin of CD-1 mice afforded significant inhibition, in a time- and dose-dependent manner, against TPA-mediated increase in (i) skin edema and hyperplasia, (ii) epidermal ornithine decarboxylase (ODC) activity, and (iii) protein expression of ODC, cyclo-oxygenase-2 and nitric oxide synthase.	Tetradecanoylphorbol Acetate	214-217	CD1 antigen complex	Mus musculus	125-129
15122342-9	2004	We found that Lupeol treatment to mouse skin resulted in the inhibition of TPA-induced (i) activation of PI3K, (ii) phosphorylation of Akt at Thr(308), (iii) activation of NF-kappaB and IKKalpha, and (iv) degradation and phosphorylation of IkappaBalpha.	Tetradecanoylphorbol Acetate	75-78	conserved helix-loop-helix ubiquitous kinase	Mus musculus	186-194
15175801-8	2004	After a regression model was applied the only independent predictor of thrombolysis resistance was baseline PAI-1&gt;34 ng/ml, such that high PAI-1 levels interfere with tPA-induced recanalization in stroke, predicting a higher susceptibility towards clot-lysis resistance and poor out-come.	Tetradecanoylphorbol Acetate	170-173	serpin family E member 1	Homo sapiens	108-113
15175801-8	2004	After a regression model was applied the only independent predictor of thrombolysis resistance was baseline PAI-1&gt;34 ng/ml, such that high PAI-1 levels interfere with tPA-induced recanalization in stroke, predicting a higher susceptibility towards clot-lysis resistance and poor out-come.	Tetradecanoylphorbol Acetate	170-173	serpin family E member 1	Homo sapiens	142-147
15064752-8	2004	One of the identified genes, the high-mobility group protein A1 (Hmga1) is induced by TPA in P+, but not in transformation-resistant P cells.	Tetradecanoylphorbol Acetate	86-89	high mobility group AT-hook 1	Homo sapiens	33-63
15064752-8	2004	One of the identified genes, the high-mobility group protein A1 (Hmga1) is induced by TPA in P+, but not in transformation-resistant P cells.	Tetradecanoylphorbol Acetate	86-89	high mobility group AT-hook 1	Homo sapiens	65-70
15064752-9	2004	We show that TPA induction of the architectural transcription factor HMGA1 is inhibited by TAM67, is extracellular-signal-regulated kinase (ERK)-activation dependent, and is mediated by AP-1.	Tetradecanoylphorbol Acetate	13-16	high mobility group AT-hook 1	Homo sapiens	69-74
15064752-10	2004	HMGA1 antisense construct transfected into P+ cells blocked HMGA1 protein expression and inhibited TPA-induced transformation indicating that HMGA1 is required for transformation.	Tetradecanoylphorbol Acetate	99-102	high mobility group AT-hook 1	Homo sapiens	0-5
15138488-13	2004	Contrary to expectation, TPA (10(-9)-10(-8) mol l(-1)) inhibited DHT-induced AREs reporter activity and decreased levels of PSA in the LNCaP-JIP-1 cells.	Tetradecanoylphorbol Acetate	25-28	kallikrein related peptidase 3	Homo sapiens	124-127
15003856-3	2004	Capsaicin sensitivity of desensitized TRPV1 ion channels recovered on application of phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	85-116	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	38-43
15003856-3	2004	Capsaicin sensitivity of desensitized TRPV1 ion channels recovered on application of phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	118-121	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	38-43
15003856-4	2004	PMA-induced recovery of desensitized TRPV1 was primarily due to influx of extracellular calcium observed during re-application of capsaicin following desensitization.	Tetradecanoylphorbol Acetate	0-3	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	37-42
15063796-6	2004	TPA stimulated ERK-dependent increases in c-Fos protein and the c-Fos content of AP-1 complexes.	Tetradecanoylphorbol Acetate	0-3	FBJ osteosarcoma oncogene	Mus musculus	42-47
15063796-6	2004	TPA stimulated ERK-dependent increases in c-Fos protein and the c-Fos content of AP-1 complexes.	Tetradecanoylphorbol Acetate	0-3	FBJ osteosarcoma oncogene	Mus musculus	64-69
15033458-10	2004	These findings indicate that TPA down-regulates Smad6 expression presumably via PKCmu-ERK-dependent pathway and up-regulates Smad7 expression via PKCmu-dependent mechanism(s) which need no MAPK and NF-kappaB activation.	Tetradecanoylphorbol Acetate	29-32	SMAD family member 6	Homo sapiens	48-53
15013845-10	2004	beta-Cryptoxanthin (10(-6)M) significantly inhibited osteoclast-like cell formation induced by RANKL and M-CSF in the presence of PMA or DcAMP.	Tetradecanoylphorbol Acetate	130-133	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	95-100
15059889-8	2004	Immunoprecipitation analyses using lysates from TPA-treated epidermis and skin papillomas showed enhanced interaction between the EGFR and Stat3.	Tetradecanoylphorbol Acetate	48-51	epidermal growth factor receptor	Mus musculus	130-134
15059882-4	2004	In these cells, (V599E)B-RAF induced constitutive mitogen activated ERK-activating kinase (MEK) and extracellular signal-regulated kinase (ERK) signaling, 12-O-tetradecanoylphorbol-13-acetate-independent growth, and tumorigenicity in nude mice.	Tetradecanoylphorbol Acetate	155-191	Braf transforming gene	Mus musculus	23-28
15023541-8	2004	Further, 12-o-tetradecanoyl-phorbol-13-acetate (TPA) induced the production of alpha6p, and this induction was abolished by PAI-1 but not alpha2-antiplasmin.	Tetradecanoylphorbol Acetate	9-46	serpin family E member 1	Homo sapiens	124-129
15023541-8	2004	Further, 12-o-tetradecanoyl-phorbol-13-acetate (TPA) induced the production of alpha6p, and this induction was abolished by PAI-1 but not alpha2-antiplasmin.	Tetradecanoylphorbol Acetate	48-51	serpin family E member 1	Homo sapiens	124-129
15047839-0	2004	Early activation of the Kaposi"s sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway.	Tetradecanoylphorbol Acetate	99-128	LDL receptor related protein associated protein 1	Homo sapiens	69-72
15047839-3	2004	The cellular CCAAT/enhancer-binding protein alpha (C/EBP alpha) is induced in TPA-treated PEL cells and contributes to transactivation of the promoters for all of these genes through both direct binding and cooperative interactions with RTA and RAP targeted to upstream C/EBP sites.	Tetradecanoylphorbol Acetate	78-81	LDL receptor related protein associated protein 1	Homo sapiens	245-248
15047839-6	2004	Cotransfected cJUN plus cFOS or TPA treatment transactivated the KSHV RTA, RAP, and MTA promoters in an AP1-binding site-dependent manner in all three promoters.	Tetradecanoylphorbol Acetate	32-35	LDL receptor related protein associated protein 1	Homo sapiens	75-78
15047839-9	2004	Both increased phosphorylated cJUN and AP1 DNA-binding activity was detected as early as 1 h after TPA treatment in PEL cells, suggesting that AP1 activity may be crucial for very early activation of the RAP, MTA, and RTA promoters during the KSHV lytic cycle.	Tetradecanoylphorbol Acetate	99-102	LDL receptor related protein associated protein 1	Homo sapiens	204-207
14634037-5	2004	Treatment of RPTC with the protein kinase C stimulator phorbol 12-myristate 13-acetate increased the activity of ER-iPLA(2) 2-fold and increased cisplatin-induced RPTC apoptosis.	Tetradecanoylphorbol Acetate	55-86	calcium-independent phospholipase A2-gamma	Oryctolagus cuniculus	116-123
14660621-3	2004	Comparable GIRK current reduction was produced by protein kinase C (PKC) activation (phorbol 12-myristate 13-acetate).	Tetradecanoylphorbol Acetate	85-116	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	11-15
14741692-5	2004	PMA-induced SRA gene and protein expression was suppressed by pravastatin with a mean 3-fold decrease at 10 microM.	Tetradecanoylphorbol Acetate	0-3	macrophage scavenger receptor 1	Homo sapiens	12-15
14745949-4	2004	For example, inhibition of myosin light chain kinase (MLCK) by application of a specific inhibitory peptide or phorbol myistate acetate (PMA) disrupts myosin assembly without significantly affecting formation of actin bands.	Tetradecanoylphorbol Acetate	137-140	myosin light chain kinase	Homo sapiens	27-52
14745949-4	2004	For example, inhibition of myosin light chain kinase (MLCK) by application of a specific inhibitory peptide or phorbol myistate acetate (PMA) disrupts myosin assembly without significantly affecting formation of actin bands.	Tetradecanoylphorbol Acetate	137-140	myosin light chain kinase	Homo sapiens	54-58
14745949-4	2004	For example, inhibition of myosin light chain kinase (MLCK) by application of a specific inhibitory peptide or phorbol myistate acetate (PMA) disrupts myosin assembly without significantly affecting formation of actin bands.	Tetradecanoylphorbol Acetate	137-140	myosin heavy chain 14	Homo sapiens	27-33
14605001-6	2004	Dexamethasone (10(-7) m) was a potent inhibitor of phorbol-12-myristate-13-acetate-induced NNT-1/BSF-3 expression.	Tetradecanoylphorbol Acetate	51-82	cardiotrophin-like cytokine factor 1	Mus musculus	91-102
14556646-4	2004	In HEK-293 (human embryonic kidney 293) cells stably expressing recombinant IRS1 and in 3T3L1 adipocytes, rosiglitazone attenuated PMA-induced IRS1 S307/S612 phosphorylation and decreased insulin-stimulated Akt phosphorylation.	Tetradecanoylphorbol Acetate	131-134	insulin receptor substrate 1	Homo sapiens	76-80
14556646-4	2004	In HEK-293 (human embryonic kidney 293) cells stably expressing recombinant IRS1 and in 3T3L1 adipocytes, rosiglitazone attenuated PMA-induced IRS1 S307/S612 phosphorylation and decreased insulin-stimulated Akt phosphorylation.	Tetradecanoylphorbol Acetate	131-134	insulin receptor substrate 1	Homo sapiens	143-147
14684160-1	2004	In the present study the molecular mechanisms underlying tetradecanoylphorbol-13-acetate (TPA) mediated regulation of the human gamma-glutamyltransferase (GGT) gene were examined.	Tetradecanoylphorbol Acetate	90-93	gamma-glutamyltransferase light chain family member 3	Homo sapiens	128-153
14684160-1	2004	In the present study the molecular mechanisms underlying tetradecanoylphorbol-13-acetate (TPA) mediated regulation of the human gamma-glutamyltransferase (GGT) gene were examined.	Tetradecanoylphorbol Acetate	90-93	gamma-glutamyltransferase light chain family member 3	Homo sapiens	155-158
8466864-3	1993	We report here that both in the I alpha 1 and the I alpha 2 regions, maximal phorbol myristate acetate (PMA) and TGF-beta 1 responsiveness of the promoters can be conferred by 327 bp spanning the transcription initiation sites and a previously identified phylogenetically conserved region.	Tetradecanoylphorbol Acetate	77-102	adrenoceptor alpha 1D	Homo sapiens	34-41
8461254-3	1993	Progesterone and testosterone were as effective as PMA in inducing IL-5 mRNA levels in the T cell hybrid NIMP-TH1 and induced IL-5, -3 and -2 mRNA accumulation in the T cell lymphoma EL-4.	Tetradecanoylphorbol Acetate	51-54	interleukin 5	Mus musculus	67-71
8461254-3	1993	Progesterone and testosterone were as effective as PMA in inducing IL-5 mRNA levels in the T cell hybrid NIMP-TH1 and induced IL-5, -3 and -2 mRNA accumulation in the T cell lymphoma EL-4.	Tetradecanoylphorbol Acetate	51-54	interleukin 5	Mus musculus	126-141
14684160-2	2004	TPA challenge of HeLa cells resulted in an increase of GGT mRNA and enzyme activity.	Tetradecanoylphorbol Acetate	0-3	gamma-glutamyltransferase light chain family member 3	Homo sapiens	55-58
14672710-2	2004	Northern blot and reverse transcription polymerase chain reaction (RT-PCR) indicated that the induction of hST3Gal V by phorbol 12-myristate 13-acetate (PMA) is regulated at transcriptional level.	Tetradecanoylphorbol Acetate	120-151	tumor-suppressor, HELA cell type	Homo sapiens	107-111
8097865-4	1993	In contrast, TPA treatment inhibited the expression of c-myc mRNA.	Tetradecanoylphorbol Acetate	13-16	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	55-60
8440709-8	1993	Whereas treatment of HepG2 cells with PMA led to an increase in the formation of gp80.gp130.IL-6 complexes determined by cross-linking, no corresponding increase in high affinity binding sites was found.	Tetradecanoylphorbol Acetate	38-41	interleukin 6 cytokine family signal transducer	Homo sapiens	86-91
14672710-2	2004	Northern blot and reverse transcription polymerase chain reaction (RT-PCR) indicated that the induction of hST3Gal V by phorbol 12-myristate 13-acetate (PMA) is regulated at transcriptional level.	Tetradecanoylphorbol Acetate	153-156	tumor-suppressor, HELA cell type	Homo sapiens	107-111
7678205-10	1993	The maximal increase in u-PAR expression (254 +/- 27% above control, n = 11) was observed when HUVEC were preincubated with 10 nM PMA for 20 hours.	Tetradecanoylphorbol Acetate	130-133	plasminogen activator, urokinase receptor	Homo sapiens	24-29
7678205-11	1993	Induction of u-PAR by PMA was inhibited when HUVEC were preincubated with either cycloheximide or H7 but was unaffected by DAM.	Tetradecanoylphorbol Acetate	22-25	plasminogen activator, urokinase receptor	Homo sapiens	13-18
14729073-1	2003	The prolonged treatment with phorbol 12-myristate 13-acetate (PMA) of a human megakaryoblastic leukemia cell line, MEG-O1, induced increase of sphingosine kinase (SPHK) enzyme activity and SPHK1 protein expression as well as SPHK1 message.	Tetradecanoylphorbol Acetate	29-60	sphingosine kinase 1	Homo sapiens	189-194
7678813-11	1993	TPA also increased the expression of GP IIb/IIIa, fibronectin and factor VIII:RAg.	Tetradecanoylphorbol Acetate	0-3	integrin alpha 2b	Mus musculus	37-43
7678813-11	1993	TPA also increased the expression of GP IIb/IIIa, fibronectin and factor VIII:RAg.	Tetradecanoylphorbol Acetate	0-3	fibronectin 1	Mus musculus	50-61
14729073-1	2003	The prolonged treatment with phorbol 12-myristate 13-acetate (PMA) of a human megakaryoblastic leukemia cell line, MEG-O1, induced increase of sphingosine kinase (SPHK) enzyme activity and SPHK1 protein expression as well as SPHK1 message.	Tetradecanoylphorbol Acetate	29-60	sphingosine kinase 1	Homo sapiens	225-230
14729073-1	2003	The prolonged treatment with phorbol 12-myristate 13-acetate (PMA) of a human megakaryoblastic leukemia cell line, MEG-O1, induced increase of sphingosine kinase (SPHK) enzyme activity and SPHK1 protein expression as well as SPHK1 message.	Tetradecanoylphorbol Acetate	62-65	sphingosine kinase 1	Homo sapiens	143-161
14729073-1	2003	The prolonged treatment with phorbol 12-myristate 13-acetate (PMA) of a human megakaryoblastic leukemia cell line, MEG-O1, induced increase of sphingosine kinase (SPHK) enzyme activity and SPHK1 protein expression as well as SPHK1 message.	Tetradecanoylphorbol Acetate	62-65	sphingosine kinase 1	Homo sapiens	163-167
8440336-1	1993	The exposure of human peripheral blood mononuclear cells to extremely low frequency pulsed electromagnetic fields (PEMFs) increased both the spontaneous and the PHA- and TPA-induced production of interleukin-1 (IL-1) and IL-6.	Tetradecanoylphorbol Acetate	170-173	interleukin 1 alpha	Homo sapiens	196-209
8440336-1	1993	The exposure of human peripheral blood mononuclear cells to extremely low frequency pulsed electromagnetic fields (PEMFs) increased both the spontaneous and the PHA- and TPA-induced production of interleukin-1 (IL-1) and IL-6.	Tetradecanoylphorbol Acetate	170-173	interleukin 1 alpha	Homo sapiens	211-215
14729073-1	2003	The prolonged treatment with phorbol 12-myristate 13-acetate (PMA) of a human megakaryoblastic leukemia cell line, MEG-O1, induced increase of sphingosine kinase (SPHK) enzyme activity and SPHK1 protein expression as well as SPHK1 message.	Tetradecanoylphorbol Acetate	62-65	sphingosine kinase 1	Homo sapiens	189-194
7682535-10	1993	In the presence of a submitogenic dose of the protein kinase C (PKC) activating agent phorbol 12-myristate 13-acetate (PMA), co-stimulation with anti-CD5 or anti-CD28 increased CD69 expression above that induced by PMA alone.	Tetradecanoylphorbol Acetate	86-117	CD5 molecule	Homo sapiens	150-153
14729073-1	2003	The prolonged treatment with phorbol 12-myristate 13-acetate (PMA) of a human megakaryoblastic leukemia cell line, MEG-O1, induced increase of sphingosine kinase (SPHK) enzyme activity and SPHK1 protein expression as well as SPHK1 message.	Tetradecanoylphorbol Acetate	62-65	sphingosine kinase 1	Homo sapiens	225-230
7682535-10	1993	In the presence of a submitogenic dose of the protein kinase C (PKC) activating agent phorbol 12-myristate 13-acetate (PMA), co-stimulation with anti-CD5 or anti-CD28 increased CD69 expression above that induced by PMA alone.	Tetradecanoylphorbol Acetate	119-122	CD5 molecule	Homo sapiens	150-153
14729073-2	2003	Protein kinase C (PKC) inhibitor prevented the PMA-induced SPHK1 gene expression.	Tetradecanoylphorbol Acetate	47-50	sphingosine kinase 1	Homo sapiens	59-64
14527959-5	2003	We found that cIAP-2 mRNA levels were markedly increased in human colon cancer cells by treatment with the phorbol ester, phorbol-12-myristate-13-acetate (PMA), or bryostatin 1.	Tetradecanoylphorbol Acetate	122-153	baculoviral IAP repeat containing 3	Homo sapiens	14-20
14527959-5	2003	We found that cIAP-2 mRNA levels were markedly increased in human colon cancer cells by treatment with the phorbol ester, phorbol-12-myristate-13-acetate (PMA), or bryostatin 1.	Tetradecanoylphorbol Acetate	155-158	baculoviral IAP repeat containing 3	Homo sapiens	14-20
8383168-8	1993	PAF also stimulated superoxide anion production alone and in combination with the macrophage activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in both cell types.	Tetradecanoylphorbol Acetate	103-140	PCNA clamp associated factor	Homo sapiens	0-3
8383168-8	1993	PAF also stimulated superoxide anion production alone and in combination with the macrophage activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in both cell types.	Tetradecanoylphorbol Acetate	142-145	PCNA clamp associated factor	Homo sapiens	0-3
14527959-6	2003	Inhibitors of the Ca2+-independent, novel PKC isoforms, but not inhibitors of MAPK, PI3-kinase, or PKA, blocked PMA-stimulated cIAP-2 mRNA expression, suggesting a role of PKC in PMA-mediated cIAP-2 induction.	Tetradecanoylphorbol Acetate	112-115	baculoviral IAP repeat containing 3	Homo sapiens	127-133
14527959-6	2003	Inhibitors of the Ca2+-independent, novel PKC isoforms, but not inhibitors of MAPK, PI3-kinase, or PKA, blocked PMA-stimulated cIAP-2 mRNA expression, suggesting a role of PKC in PMA-mediated cIAP-2 induction.	Tetradecanoylphorbol Acetate	112-115	baculoviral IAP repeat containing 3	Homo sapiens	192-198
14532285-8	2003	The effect of PKC-epsilon on hsp90 beta expression seems to be stimuli-specific, as phorbol myristate acetate-mediated hsp90 beta expression was PKC-epsilon-independent.	Tetradecanoylphorbol Acetate	84-109	protein kinase C epsilon	Homo sapiens	14-25
8429689-0	1993	Up-regulation of small GTP-binding proteins smg P21A and ras P21S during TPA-induced differentiation of human leukemia cell lines.	Tetradecanoylphorbol Acetate	73-76	RAP1A, member of RAS oncogene family pseudogene	Homo sapiens	44-48
8472844-11	1993	Progesterone modulation of GnRH-stimulated FSH secretion was multiphasic, i.e. increased at 0-6 h, unchanged at 9 h and suppressed at 24 h. Acute and chronic exposures to P similarly modulated A23187-stimulated FSH release, whereas both P treatments increased PMA-stimulated FSH secretion.	Tetradecanoylphorbol Acetate	260-263	gonadotropin releasing hormone 1	Rattus norvegicus	27-31
14644416-2	2003	Northern blot and reverse transcription polymerase chain reaction indicated that the induction of hST3Gal V by TPA is regulated at the transcriptional level.	Tetradecanoylphorbol Acetate	111-114	tumor-suppressor, HELA cell type	Homo sapiens	98-102
8512018-4	1993	IL-1 alpha transcripts could be induced with phorbol myristate acetate (PMA) or PMA plus lipopolysaccharide (LPS) in 2 of 4 cell lines and IL-1 beta mRNA in 2 of 4 cell lines.	Tetradecanoylphorbol Acetate	45-70	interleukin 1 alpha	Homo sapiens	0-10
8512018-4	1993	IL-1 alpha transcripts could be induced with phorbol myristate acetate (PMA) or PMA plus lipopolysaccharide (LPS) in 2 of 4 cell lines and IL-1 beta mRNA in 2 of 4 cell lines.	Tetradecanoylphorbol Acetate	72-75	interleukin 1 alpha	Homo sapiens	0-10
8512018-4	1993	IL-1 alpha transcripts could be induced with phorbol myristate acetate (PMA) or PMA plus lipopolysaccharide (LPS) in 2 of 4 cell lines and IL-1 beta mRNA in 2 of 4 cell lines.	Tetradecanoylphorbol Acetate	80-83	interleukin 1 alpha	Homo sapiens	0-10
8512018-7	1993	After treatment with PMA and LPS, IL-1 alpha was detected in the culture fluid from two other lines and IL-1 beta in the medium from three lines.	Tetradecanoylphorbol Acetate	21-24	interleukin 1 alpha	Homo sapiens	34-44
14691289-7	2003	Phorbol 12-myristate 13-acetate-induced MCP-1 production, in the absence or presence of pioglitazone, were assayed in cultured macrophages.	Tetradecanoylphorbol Acetate	0-31	C-C motif chemokine ligand 2	Rattus norvegicus	40-45
8432620-1	1993	We investigated the role of protein kinase C activator phorbol 12-myristate 13-acetate (PMA) on IL-2-driven NK cell differentiation, by using an in vitro model previously set up by our laboratory.	Tetradecanoylphorbol Acetate	55-86	interleukin 2	Mus musculus	96-100
8432620-1	1993	We investigated the role of protein kinase C activator phorbol 12-myristate 13-acetate (PMA) on IL-2-driven NK cell differentiation, by using an in vitro model previously set up by our laboratory.	Tetradecanoylphorbol Acetate	88-91	interleukin 2	Mus musculus	96-100
8432620-5	1993	We now report that: (1) PMA inhibited the IL-2-induced NK cell differentiation and induced development of cells which lyse the NK-resistant target P815.	Tetradecanoylphorbol Acetate	24-27	interleukin 2	Mus musculus	42-46
14691289-11	2003	Phorbol 12-myristate 13-acetate-stimulated cultured macrophages in the presence of pioglitazone produced significantly lower levels of MCP-1 than the stimulated control in the absence of pioglitazone.	Tetradecanoylphorbol Acetate	0-31	C-C motif chemokine ligand 2	Rattus norvegicus	135-140
8397795-9	1993	c-fos and c-jun proteins synthesized in vitro could bind to the DNA fragment containing this sequence, but the binding was weaker than to the TPA-responsive element (TGACTCA).	Tetradecanoylphorbol Acetate	142-145	FBJ osteosarcoma oncogene	Mus musculus	0-5
13679379-3	2003	In contrast to a transient induction by H2O2, TPA persistently activated fra-1 transcription, principally at the transcriptional level.	Tetradecanoylphorbol Acetate	46-49	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	73-78
8247749-1	1993	The effect of phorbol 12-myristate 13-acetate (TPA) on the c-fos mRNA expression in the osteoblastic MC3T3-E1 cells cultured in a low-calcium environment was examined.	Tetradecanoylphorbol Acetate	14-45	FBJ osteosarcoma oncogene	Mus musculus	59-64
13679379-7	2003	Thus, cooperative interactions between factors binding to multiple cis-elements of the -379/-283 promoter region appear to regulate TPA-induced fra-1 transcription in HBE cells.	Tetradecanoylphorbol Acetate	132-135	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	144-149
13679379-11	2003	Chromatin immunoprecipitation assays revealed an enhanced recruitment of c-Jun, Jun-D, and Fra-2 to the endogenous fra-1 promoter upon TPA stimulation.	Tetradecanoylphorbol Acetate	135-138	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	115-120
13679379-12	2003	These results underscore the regulatory role of c-Jun, Jun-D, and Fra-2 in TPA-inducible fra-1 expression in HBE cells in vivo.	Tetradecanoylphorbol Acetate	75-78	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	89-94
14623254-3	2003	In contrast, during megakaryocytic differentiation by 12-O-tetradecanoyl phorbol 13-acetate (TPA), GSTP1-1 expression decreased at both mRNA and protein levels.	Tetradecanoylphorbol Acetate	54-91	glutathione S-transferase pi 1	Homo sapiens	99-106
14623254-3	2003	In contrast, during megakaryocytic differentiation by 12-O-tetradecanoyl phorbol 13-acetate (TPA), GSTP1-1 expression decreased at both mRNA and protein levels.	Tetradecanoylphorbol Acetate	93-96	glutathione S-transferase pi 1	Homo sapiens	99-106
12960165-6	2003	The p38 MAPK inhibitor SB202190 and overexpression of dominant negative mutants of MAPK kinase 4 (MKK4), MKK6, and p38 inhibited the TPA-dependent induction of Prx I gene transcription.	Tetradecanoylphorbol Acetate	133-136	mitogen-activated protein kinase kinase 6	Rattus norvegicus	105-109
12919959-6	2003	Here, we demonstrated that dexamethasone, a synthetic analog of glucocorticoid, known to inhibit tumor promotion in vivo, not only suppressed TPA-induced OPN mRNA expression and inhibited tumorigenic transformation of JB6 Cl41.5a cells (as previously shown in JB6 Cl22 and Cl41 cells), but also that the addition of OPN partially restored dexamethasone suppression of TPA-induced cell transformation.	Tetradecanoylphorbol Acetate	142-145	secreted phosphoprotein 1	Homo sapiens	316-319
12919959-7	2003	Therefore, we tested the hypothesis that OPN induction is required for tumor promoter-induced transformation of JB6 cells by examining (i) whether the addition of OPN will induce transformation, (ii) whether antisense OPN expression will inhibit TPA-induced transformation and (iii) if the latter experiment showed inhibition of TPA-induced transformation whether the addition of OPN will rescue this effect.	Tetradecanoylphorbol Acetate	246-249	secreted phosphoprotein 1	Homo sapiens	41-44
12919959-7	2003	Therefore, we tested the hypothesis that OPN induction is required for tumor promoter-induced transformation of JB6 cells by examining (i) whether the addition of OPN will induce transformation, (ii) whether antisense OPN expression will inhibit TPA-induced transformation and (iii) if the latter experiment showed inhibition of TPA-induced transformation whether the addition of OPN will rescue this effect.	Tetradecanoylphorbol Acetate	329-332	secreted phosphoprotein 1	Homo sapiens	41-44
12947120-3	2003	Here we found that 12-O-tetradecanoylphorbol-13-acetate (TPA) could induce cell apoptosis via induction of TR3 and E2F1 expression in LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	57-60	E2F transcription factor 1	Homo sapiens	115-119
12947120-5	2003	These data suggest that TPA is able to induce LNCaP cell apoptosis via induction of TR3 resulting in the induction of E2F1.	Tetradecanoylphorbol Acetate	24-27	E2F transcription factor 1	Homo sapiens	118-122
12947120-8	2003	Taken together, these data suggest that TPA is able to induce cell apoptosis via a TPA --&gt; TR3 --&gt; E2F1 --&gt; apoptosis pathway in LNCaP cells.	Tetradecanoylphorbol Acetate	40-43	E2F transcription factor 1	Homo sapiens	105-109
12920127-9	2003	Finally, we have determined that the proteasomal activity is required not only for phosphate-induced expression of osteopontin but also for the induction of osteopontin in response to 12-O-tetradecanoylphorbol 13-acetate and okadaic acid.	Tetradecanoylphorbol Acetate	184-220	secreted phosphoprotein 1	Homo sapiens	157-168
12867426-5	2003	We also show that two TSC2 mutants derived from TSC patients are defective in repressing phorbol 12-myristate 13-acetate-induced 4E-BP1 phosphorylation.	Tetradecanoylphorbol Acetate	89-120	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	129-135
12951044-0	2003	Induction of plasminogen activator inhibitor-2 is associated with suppression of invasive activity in TPA-mediated differentiation of human prostate cancer cells.	Tetradecanoylphorbol Acetate	102-105	serpin family B member 2	Homo sapiens	13-46
12951044-3	2003	We successfully detected plasminogen activator inhibitor type-2 (PAI-2) as one gene up-regulated by TPA treatment.	Tetradecanoylphorbol Acetate	100-103	serpin family B member 2	Homo sapiens	25-63
12951044-3	2003	We successfully detected plasminogen activator inhibitor type-2 (PAI-2) as one gene up-regulated by TPA treatment.	Tetradecanoylphorbol Acetate	100-103	serpin family B member 2	Homo sapiens	65-70
12951044-4	2003	The change in expression of PAI-2 by TPA was blocked by treatment with protein kinase C or mitogen-activated protein kinase inhibitors.	Tetradecanoylphorbol Acetate	37-40	serpin family B member 2	Homo sapiens	28-33
12951044-5	2003	We also found that secretion of PAI-2 protein was increased by TPA treatment.	Tetradecanoylphorbol Acetate	63-66	serpin family B member 2	Homo sapiens	32-37
12951044-6	2003	Moreover, we demonstrated that suppression of invasive activity of TSU-Pr1 cells by TPA treatment was blocked by co-treatment with anti-PAI-2 antibody.	Tetradecanoylphorbol Acetate	84-87	serpin family B member 2	Homo sapiens	136-141
12951044-7	2003	These results suggest that induction of PAI-2 is associated with suppression of invasive activity in TSU-Pr1 cells treated with TPA.	Tetradecanoylphorbol Acetate	128-131	serpin family B member 2	Homo sapiens	40-45
12963846-6	2003	IkappaBalphaM cells also displayed impairment in NaB- and PMA-mediated induction of p21CIP1 and phosphorylation (inactivation) of p34cdc2, as well as diminished levels of pRb-bound E2F1.	Tetradecanoylphorbol Acetate	58-61	cyclin dependent kinase 1	Homo sapiens	130-137
12963846-6	2003	IkappaBalphaM cells also displayed impairment in NaB- and PMA-mediated induction of p21CIP1 and phosphorylation (inactivation) of p34cdc2, as well as diminished levels of pRb-bound E2F1.	Tetradecanoylphorbol Acetate	58-61	E2F transcription factor 1	Homo sapiens	181-185
12949242-6	2003	Although inducible L-selectin shedding by phorbol 12-myristate 13-acetate stimulation was not observed by these cells in short-term assays, basal turnover did occur, resulting in the production of soluble L-selectin, as determined by enzyme-linked immunosorbent assay.	Tetradecanoylphorbol Acetate	42-73	selectin L	Homo sapiens	19-29
12878187-2	2003	Here, we demonstrate that PKC activation via phorbol 12-myristate 13-acetate (PMA) treatment of MDA-MB-231 cells inhibits EGF-induced cell spreading, the initial event of motility and chemotaxis.	Tetradecanoylphorbol Acetate	45-76	epidermal growth factor	Homo sapiens	122-125
12878187-2	2003	Here, we demonstrate that PKC activation via phorbol 12-myristate 13-acetate (PMA) treatment of MDA-MB-231 cells inhibits EGF-induced cell spreading, the initial event of motility and chemotaxis.	Tetradecanoylphorbol Acetate	78-81	epidermal growth factor	Homo sapiens	122-125
12754318-2	2003	Differentiation of SHSY-5Y cells with either retinoic acid (RA) or 12-o-tetradecanoyl-phorbol-13-acetate (TPA) significantly increased MOR mRNA levels.	Tetradecanoylphorbol Acetate	67-104	opioid receptor mu 1	Homo sapiens	135-138
12754318-2	2003	Differentiation of SHSY-5Y cells with either retinoic acid (RA) or 12-o-tetradecanoyl-phorbol-13-acetate (TPA) significantly increased MOR mRNA levels.	Tetradecanoylphorbol Acetate	106-109	opioid receptor mu 1	Homo sapiens	135-138
12939399-3	2003	Assay of telomerase enzyme activity, hTERT mRNA, and reporter gene assays confirmed that the hTERT promoter was silenced during 12-O-tetradecanoylphorbol-13-acetate-induced myogenic differentiation of telomerase-positive RD cells.	Tetradecanoylphorbol Acetate	128-164	telomerase reverse transcriptase	Homo sapiens	37-42
12939399-3	2003	Assay of telomerase enzyme activity, hTERT mRNA, and reporter gene assays confirmed that the hTERT promoter was silenced during 12-O-tetradecanoylphorbol-13-acetate-induced myogenic differentiation of telomerase-positive RD cells.	Tetradecanoylphorbol Acetate	128-164	telomerase reverse transcriptase	Homo sapiens	93-98
12606313-2	2003	We previously showed that SERCA2 downregulation can be simulated in cultured neonatal rat ventricular myocytes (NRVM) by treatment with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	173-204	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	26-32
12854826-13	2003	Finally, osteoblast differentiation and formation of a mineralized bone matrix were enhanced in osteoblast cultures derived from tPA-/-:uPA-/- mice.	Tetradecanoylphorbol Acetate	129-132	plasminogen activator, urokinase	Mus musculus	136-139
12788225-3	2003	PMA-induced galectin-3 overexpression was blocked by: protein kinase C inhibitors staurosporine, calphostin C, and apigenin; tyrosine-specific protein kinase inhibitors genistein and tyrphostin A25; PD 98059, a selective inhibitor of mitogen-activated protein kinase (MAPK) kinase 1 (MEK1 or MKK1); and SB 203580, a specific inhibitor of p38 MAPK.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 1	Homo sapiens	284-288
12788225-3	2003	PMA-induced galectin-3 overexpression was blocked by: protein kinase C inhibitors staurosporine, calphostin C, and apigenin; tyrosine-specific protein kinase inhibitors genistein and tyrphostin A25; PD 98059, a selective inhibitor of mitogen-activated protein kinase (MAPK) kinase 1 (MEK1 or MKK1); and SB 203580, a specific inhibitor of p38 MAPK.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 1	Homo sapiens	292-296
12759452-1	2003	Tumor promoters such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) are proinflammatory agents, and their mechanism of action in epithelial carcinogenesis has been linked to the release of IL-1 alpha and the induction of chronic inflammation in skin.	Tetradecanoylphorbol Acetate	42-78	interleukin 1 alpha	Mus musculus	206-216
12759452-1	2003	Tumor promoters such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) are proinflammatory agents, and their mechanism of action in epithelial carcinogenesis has been linked to the release of IL-1 alpha and the induction of chronic inflammation in skin.	Tetradecanoylphorbol Acetate	80-83	interleukin 1 alpha	Mus musculus	206-216
12759452-3	2003	Strikingly, the K14/IL-1 alpha mice were completely resistant to papilloma and carcinoma formation induced by a two-stage DMBA/TPA protocol, while littermate controls developed both tumor types.	Tetradecanoylphorbol Acetate	127-130	keratin 14	Mus musculus	16-19
12759452-3	2003	Strikingly, the K14/IL-1 alpha mice were completely resistant to papilloma and carcinoma formation induced by a two-stage DMBA/TPA protocol, while littermate controls developed both tumor types.	Tetradecanoylphorbol Acetate	127-130	interleukin 1 alpha	Mus musculus	20-30
12773514-6	2003	Also, Lck and Fyn as well as MEK1/ERK and p38 MAPK were found to regulate MICA expression in anti-CD28/phorbol 12-myristate 13-acetate-stimulated T cells.	Tetradecanoylphorbol Acetate	103-134	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	6-9
12773514-6	2003	Also, Lck and Fyn as well as MEK1/ERK and p38 MAPK were found to regulate MICA expression in anti-CD28/phorbol 12-myristate 13-acetate-stimulated T cells.	Tetradecanoylphorbol Acetate	103-134	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	14-17
12773514-6	2003	Also, Lck and Fyn as well as MEK1/ERK and p38 MAPK were found to regulate MICA expression in anti-CD28/phorbol 12-myristate 13-acetate-stimulated T cells.	Tetradecanoylphorbol Acetate	103-134	mitogen-activated protein kinase kinase 1	Homo sapiens	29-33
12618431-3	2003	In a first part, we show that the expression of 4E-BP1 protein and transcript decreases in hematopoietic cell lines cultivated in the presence of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	146-177	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	48-54
12618431-3	2003	In a first part, we show that the expression of 4E-BP1 protein and transcript decreases in hematopoietic cell lines cultivated in the presence of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	179-182	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	48-54
12640676-9	2003	Additionally, some TPA-induced genes, such as Sprr1A, Saa3, JunB, Il4ralpha, Gp38, RalGDS and Slpi exhibit high basal level in advanced stages of skin carcinogenesis, suggesting that at least a subgroup of the identified TPA-regulated genes may contribute to tumour progression and metastasis.	Tetradecanoylphorbol Acetate	19-22	jun B proto-oncogene	Mus musculus	60-64
12640676-9	2003	Additionally, some TPA-induced genes, such as Sprr1A, Saa3, JunB, Il4ralpha, Gp38, RalGDS and Slpi exhibit high basal level in advanced stages of skin carcinogenesis, suggesting that at least a subgroup of the identified TPA-regulated genes may contribute to tumour progression and metastasis.	Tetradecanoylphorbol Acetate	19-22	podoplanin	Mus musculus	77-81
12609995-2	2003	In the present study, PKG was found to be a target for phorbol 12-myristate 13-acetate (PMA)-responsive protein kinase C (PKC).	Tetradecanoylphorbol Acetate	55-86	protein kinase cGMP-dependent 1	Homo sapiens	22-25
12609995-2	2003	In the present study, PKG was found to be a target for phorbol 12-myristate 13-acetate (PMA)-responsive protein kinase C (PKC).	Tetradecanoylphorbol Acetate	88-91	protein kinase cGMP-dependent 1	Homo sapiens	22-25
12595531-9	2003	Furthermore, T cells treated with soluble anti-TCR antibody produced IL-2 when phorbol 12-myristate 13-acetate, which activates ERK, was present in the culture medium 2-6 h after the start of stimulation.	Tetradecanoylphorbol Acetate	79-110	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	47-50
12694376-5	2003	Both wound-healing and Boyden migration assays showed that TPA treatment promoted neuronal migration of GT1 cells; however, cotreatment of TPA with safingol or rottlerin (a PKC delta-selective inhibitor) clearly blocked this TPA effect, indicating that both PKC alpha and PKC delta may be positive regulators of neuronal migration.	Tetradecanoylphorbol Acetate	59-62	beta-1,4-galactosyltransferase 1	Homo sapiens	104-107
12694376-5	2003	Both wound-healing and Boyden migration assays showed that TPA treatment promoted neuronal migration of GT1 cells; however, cotreatment of TPA with safingol or rottlerin (a PKC delta-selective inhibitor) clearly blocked this TPA effect, indicating that both PKC alpha and PKC delta may be positive regulators of neuronal migration.	Tetradecanoylphorbol Acetate	139-142	beta-1,4-galactosyltransferase 1	Homo sapiens	104-107
12693948-11	2003	Indeed, PD98059 and SB203580, two selective inhibitors of MEK1/2 and p38MAPK, respectively, inhibited p67(PHOX) phosphorylation in fMLP- and PMA-stimulated neutrophils, with additive effects, thus suggesting that they also target different sites in vivo.	Tetradecanoylphorbol Acetate	141-144	mitogen-activated protein kinase kinase 1	Homo sapiens	58-64
12666133-4	2003	We produced and characterized a monoclonal antibody (MAb) 11G1 against purified alpha-enolase, which abrogated about 90% of cell-dependent plasminogen activation by either uPA or tPA on leukocytoid cell lines of different lineages: B-lymphocytic, T-lymphocytic, granulocytic, and monocytic cells.	Tetradecanoylphorbol Acetate	179-182	enolase 1	Homo sapiens	80-93
1336820-4	1992	A similar restriction of synaptophysin to long processes is also observed following differentiation and process formation induced by other treatments such as incubation in reduced serum or treatment with cyclic AMP or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	218-243	synaptophysin	Rattus norvegicus	25-38
1335418-3	1992	PMA treatment caused a concentration- and time-dependent increase in both c-Fos and Jun immunoreactivity in contrast to cAMP elevation that had only a slight effect.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-79
1429597-2	1992	AP-1 binds to 12-O-tetradecanoylphorbol-13-acetate-responsive elements (TREs) palindromic sequences.	Tetradecanoylphorbol Acetate	14-50	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
1480166-0	1992	Transcription induction of c-Ki-ras with the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in normal and transformed liver cells.	Tetradecanoylphorbol Acetate	61-97	KRAS proto-oncogene, GTPase	Rattus norvegicus	27-35
1480166-0	1992	Transcription induction of c-Ki-ras with the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in normal and transformed liver cells.	Tetradecanoylphorbol Acetate	99-102	KRAS proto-oncogene, GTPase	Rattus norvegicus	27-35
1480166-1	1992	Results from nuclear run-off assays show that exposure of hepatocytes and Reuber H35B hepatoma cells to the tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), leads to enhanced transcription of c-Ki-ras gene.	Tetradecanoylphorbol Acetate	125-161	KRAS proto-oncogene, GTPase	Rattus norvegicus	204-212
1445248-3	1992	Short-term preincubation of cells with the phorbol ester 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA), which activates protein kinase C (PKC), blocked the increase in [Ca2+]i induced by TLC, but did not alter that mediated by vasopressin.	Tetradecanoylphorbol Acetate	108-111	protein kinase C, gamma	Rattus norvegicus	130-146
1445248-3	1992	Short-term preincubation of cells with the phorbol ester 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA), which activates protein kinase C (PKC), blocked the increase in [Ca2+]i induced by TLC, but did not alter that mediated by vasopressin.	Tetradecanoylphorbol Acetate	108-111	protein kinase C, gamma	Rattus norvegicus	148-151
1385002-1	1992	In previous experiments, pretreatment of CD-1 mouse skin with prostratin (12-deoxyphorbol 13-acetate) inhibited hyperplasia, induction of ornithine decarboxylase and edema in response to acute treatment with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	208-239	ornithine decarboxylase, structural 1	Mus musculus	138-161
1423878-1	1992	The Ha-ras oncogene has been shown to be point-mutated and overexpressed in papillomas induced by the two-stage skin tumorigenesis regimen of 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	199-235	Harvey rat sarcoma virus oncogene	Mus musculus	4-10
1423878-1	1992	The Ha-ras oncogene has been shown to be point-mutated and overexpressed in papillomas induced by the two-stage skin tumorigenesis regimen of 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	237-240	Harvey rat sarcoma virus oncogene	Mus musculus	4-10
12606436-7	2003	The treatment of BESCs with 12-O-tetradecanoylphorbol 13-acetate resulted in a significant increase in the level of TIMP-1 but a significant decrease in the level of TIMP-2 in the stromal cells.	Tetradecanoylphorbol Acetate	28-64	TIMP metallopeptidase inhibitor 1	Bos taurus	116-122
1428115-7	1992	Phorbol 12-myristate 13-acetate-induced phosphorylation of pp42 indicates the possibility of an association between protein kinase C and the signal transduction pathway of angiotensin II-induced pp42 phosphorylation.	Tetradecanoylphorbol Acetate	0-31	eukaryotic translation initiation factor 2 subunit gamma	Rattus norvegicus	59-63
1428115-7	1992	Phorbol 12-myristate 13-acetate-induced phosphorylation of pp42 indicates the possibility of an association between protein kinase C and the signal transduction pathway of angiotensin II-induced pp42 phosphorylation.	Tetradecanoylphorbol Acetate	0-31	eukaryotic translation initiation factor 2 subunit gamma	Rattus norvegicus	195-199
12606436-10	2003	The production of TIMP-1 in BT-1 cells was also augmented by IL-1alpha, TNFalpha, and HGF at the level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	157-193	TIMP metallopeptidase inhibitor 1	Bos taurus	18-24
1480173-9	1992	8-Bromo-cAMP and phorbol 12-myristate 13-acetate (PMA) caused increases in the abundance of c-fos and c-jun transcripts.	Tetradecanoylphorbol Acetate	17-48	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-97
12601690-6	2003	Vitamin D(3) treatment or cytochalasin D in combination with PMA treatment did not affect WASP expression suggesting that adhesion and cytoskeletal integrity were both essential to regulate WASP expression.	Tetradecanoylphorbol Acetate	61-64	WASP actin nucleation promoting factor	Homo sapiens	190-194
1480173-9	1992	8-Bromo-cAMP and phorbol 12-myristate 13-acetate (PMA) caused increases in the abundance of c-fos and c-jun transcripts.	Tetradecanoylphorbol Acetate	50-53	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-97
1437149-1	1992	Transcription factor AP-1 is constituted by the various products of the fos and jun proto-oncogene family members, which associate as dimers to bind with variable efficiency to 12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive promoter elements (TREs).	Tetradecanoylphorbol Acetate	177-214	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-25
1437149-1	1992	Transcription factor AP-1 is constituted by the various products of the fos and jun proto-oncogene family members, which associate as dimers to bind with variable efficiency to 12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive promoter elements (TREs).	Tetradecanoylphorbol Acetate	177-214	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-75
1437149-1	1992	Transcription factor AP-1 is constituted by the various products of the fos and jun proto-oncogene family members, which associate as dimers to bind with variable efficiency to 12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive promoter elements (TREs).	Tetradecanoylphorbol Acetate	216-219	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-25
1437149-1	1992	Transcription factor AP-1 is constituted by the various products of the fos and jun proto-oncogene family members, which associate as dimers to bind with variable efficiency to 12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive promoter elements (TREs).	Tetradecanoylphorbol Acetate	216-219	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-75
1437150-0	1992	Differential induction of c-fos and c-jun proto-oncogenes and AP-1 activity by tumor promoter 12-O-tetradecanoyl phorbol 13-acetate in cells at different stages of tumor promotion in vitro.	Tetradecanoylphorbol Acetate	94-131	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	26-31
1437150-0	1992	Differential induction of c-fos and c-jun proto-oncogenes and AP-1 activity by tumor promoter 12-O-tetradecanoyl phorbol 13-acetate in cells at different stages of tumor promotion in vitro.	Tetradecanoylphorbol Acetate	94-131	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	36-41
12479793-5	2003	Exposing fibroblasts derived from RIP(-/-) mice to either cobalt or PMA resulted in an equivalent HIF-1 alpha induction to that seen in RIP(+/+) fibroblasts.	Tetradecanoylphorbol Acetate	68-71	hypoxia inducible factor 1, alpha subunit	Mus musculus	98-109
12594296-7	2003	In eosinophils stimulated with PMA, a pronounced shift of cytosolic Rac to p22(phox)-positive plasma membrane was observed by confocal microscopy, whereas neutrophils directed Rac2 mainly to intracellular sites coexpressing p22(phox).	Tetradecanoylphorbol Acetate	31-34	calcineurin like EF-hand protein 1	Homo sapiens	75-78
1328224-9	1992	Shedding of the extracellular domain of TNF-R2 was induced by 4 beta-phorbol 12-myristate 13-acetate but not by TNF-alpha or TNF-beta.	Tetradecanoylphorbol Acetate	62-100	TNF receptor superfamily member 1B	Homo sapiens	40-46
12594296-7	2003	In eosinophils stimulated with PMA, a pronounced shift of cytosolic Rac to p22(phox)-positive plasma membrane was observed by confocal microscopy, whereas neutrophils directed Rac2 mainly to intracellular sites coexpressing p22(phox).	Tetradecanoylphorbol Acetate	31-34	calcineurin like EF-hand protein 1	Homo sapiens	224-227
12688321-3	2003	Pretreatment with phorbol 12-myristate 13-acetate (PMA), an activator of PKC, prevented TNF-alpha-induced rapid onset of apoptosis, which occurs at 3 h culture with TNF-alpha, concomitantly with the up-regulation of c-Myc protein expression.	Tetradecanoylphorbol Acetate	18-49	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	216-221
1331128-7	1992	Addition of a combination of cholera toxin and TPA caused a synergistic induction of c-fos expression.	Tetradecanoylphorbol Acetate	47-50	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	85-90
1406636-6	1992	In this study, we mapped the sequences in the c-jun promoter responsible for epidermal growth factor (EGF), serum, and 12-O-tetradecanoylphorbol-13-acetate (TPA) induction by deletion and point mutational analysis.	Tetradecanoylphorbol Acetate	119-155	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	46-51
1406636-6	1992	In this study, we mapped the sequences in the c-jun promoter responsible for epidermal growth factor (EGF), serum, and 12-O-tetradecanoylphorbol-13-acetate (TPA) induction by deletion and point mutational analysis.	Tetradecanoylphorbol Acetate	157-160	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	46-51
12688321-3	2003	Pretreatment with phorbol 12-myristate 13-acetate (PMA), an activator of PKC, prevented TNF-alpha-induced rapid onset of apoptosis, which occurs at 3 h culture with TNF-alpha, concomitantly with the up-regulation of c-Myc protein expression.	Tetradecanoylphorbol Acetate	51-54	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	216-221
1406636-10	1992	Double mutation of the RSRF and AP-1 sites suggests that there is an additional TPA-responsive element between -80 and +150 in the c-jun promoter.	Tetradecanoylphorbol Acetate	80-83	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	32-36
1406636-10	1992	Double mutation of the RSRF and AP-1 sites suggests that there is an additional TPA-responsive element between -80 and +150 in the c-jun promoter.	Tetradecanoylphorbol Acetate	80-83	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-136
12688321-7	2003	Up-regulation of c-Myc protein evoked by pretreatment with PMA for a short time could disturb the signaling pathway of the ceramide and sphingosine, which are known to function as the endogenous modulators mediating the apoptotic signal of TNF-alpha.	Tetradecanoylphorbol Acetate	59-62	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	17-22
12606037-4	2003	Overexpression of arfaptin 1, a 39 kDa ARF-binding protein that inhibits in vitro activation of cholera toxin ADP-ribosyltransferase and phospholipase D (PLD) by ARF, inhibited PMA-stimulated MMP-9 and PLD activation.	Tetradecanoylphorbol Acetate	177-180	ADP ribosylation factor interacting protein 1	Homo sapiens	18-28
1394118-5	1992	The calmodulin antagonist cyclosporine A, which does not suppress PKC activity, very effectively inhibits the TPA-induced edema and down regulation of PKC.	Tetradecanoylphorbol Acetate	110-113	calmodulin 2	Mus musculus	4-14
12566297-8	2003	Again, DMBA/PMA-induced tumor formation was less (71% versus 89%) and significantly delayed (P = 0.02) in K14-survivin p53+/- animals compared with p53+/- non-Tgs.	Tetradecanoylphorbol Acetate	12-15	keratin 14	Mus musculus	106-109
1525167-4	1992	The results demonstrate that these cells express low levels of PKC alpha and PKC beta transcripts and exhibit an attenuated induction of c-jun expression following treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	179-215	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-142
1525167-4	1992	The results demonstrate that these cells express low levels of PKC alpha and PKC beta transcripts and exhibit an attenuated induction of c-jun expression following treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	217-220	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-142
12566297-8	2003	Again, DMBA/PMA-induced tumor formation was less (71% versus 89%) and significantly delayed (P = 0.02) in K14-survivin p53+/- animals compared with p53+/- non-Tgs.	Tetradecanoylphorbol Acetate	12-15	transformation related protein 53, pseudogene	Mus musculus	119-122
12542530-10	2003	Finally, immunohistochemistry demonstrated an inhibition in the production of the pro-inflammatory cytokines interleukin-1alpha and tumor necrosis factor alpha in the oxysterol-treated sites from both TPA- and oxazolone-treated animals.	Tetradecanoylphorbol Acetate	201-204	interleukin 1 alpha	Mus musculus	109-127
1389096-9	1992	The expression of 65-kDa HSP mRNA was increased in RINm5F cells following heat shock, while no induction was seen after stimulation with glucose, TPA or IBMX.	Tetradecanoylphorbol Acetate	146-149	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	25-28
12519122-6	2003	Using northern blots, we show that in DMEL-2 cells, TPA significantly increases the messenger ribonucleic acid (mRNA) levels of the tyrosinase gene family (tyrosinase, Tyrp1 and Dct) and the expression of Mitf.	Tetradecanoylphorbol Acetate	52-55	tyrosinase	Mus musculus	132-142
1355014-1	1992	The effects of several cytokines and phorbol myristate acetate (PMA) on LFA-1 and ICAM-1 expression on a human eosinophilic leukemia cell line, EoL-3, were investigated and compared with those of a human monocytic leukemia cell line, U937.	Tetradecanoylphorbol Acetate	64-67	intercellular adhesion molecule 1	Homo sapiens	82-88
12519122-6	2003	Using northern blots, we show that in DMEL-2 cells, TPA significantly increases the messenger ribonucleic acid (mRNA) levels of the tyrosinase gene family (tyrosinase, Tyrp1 and Dct) and the expression of Mitf.	Tetradecanoylphorbol Acetate	52-55	tyrosinase	Mus musculus	156-166
14517402-4	2003	E-selectin is strongly expressed on HUVEC activated by TNFalpha or TPA.	Tetradecanoylphorbol Acetate	67-70	selectin E	Homo sapiens	0-10
1324159-13	1992	The ET-1-mediated inhibition of both the FSH-stimulated accumulation of progesterone and cAMP after 24-h incubation was mimicked by an activator of protein kinase-C, phorbol 12-myristate 13-acetate, but not by an inactive phorbol.	Tetradecanoylphorbol Acetate	166-197	endothelin-1	Sus scrofa	4-8
1323817-5	1992	Transfection of the smg p21 cDNAs inhibited the activated ras p21-, PDGF- or TPA-stimulated c-fos-luciferase expression, but did not inhibit the activated c-raf-1 kinase- or Bt2cAMP-stimulated reaction.	Tetradecanoylphorbol Acetate	77-80	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	24-27
12507602-5	2003	5-(N-ethyl-N-isopropyl)-amiloride, selective blocker of NHE1, caused a dose-dependent inhibition of the PMA-induced Na(+) influx with IC(50) of 0.27 microM.	Tetradecanoylphorbol Acetate	104-107	solute carrier family 9 member A1	Canis lupus familiaris	56-60
20732145-4	1992	ADR (10 mum) and, to a lesser degree, DAU (5 mum) also enhance 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC activity, but, in contrast to ADR, 10-50 mum-DAU inhibit the ODC response to TPA by 50% or more.	Tetradecanoylphorbol Acetate	63-99	ornithine decarboxylase, structural 1	Mus musculus	114-117
20732145-4	1992	ADR (10 mum) and, to a lesser degree, DAU (5 mum) also enhance 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC activity, but, in contrast to ADR, 10-50 mum-DAU inhibit the ODC response to TPA by 50% or more.	Tetradecanoylphorbol Acetate	101-104	ornithine decarboxylase, structural 1	Mus musculus	114-117
20732145-5	1992	The induction and superinduction of ODC activities by ADR and/or TPA are all inhibited by the Ca(2+)-channel blocker verapamil.	Tetradecanoylphorbol Acetate	65-68	ornithine decarboxylase, structural 1	Mus musculus	36-39
12507602-9	2003	The data indicate that the Na(+)-H(+) exchanger in the frog erythrocytes is quiescent under basal conditions and can be markedly stimulated by PMA.	Tetradecanoylphorbol Acetate	143-146	solute carrier family 9 member A1	Canis lupus familiaris	27-47
12499080-2	2003	MEM significantly inhibited PMA-induced secretions of IL-8 and MCP-1 proteins in a dose-dependent manner.	Tetradecanoylphorbol Acetate	28-31	C-C motif chemokine ligand 2	Homo sapiens	63-68
1510117-5	1992	Furthermore, sphingosine (100 microM), a protein kinase C (PKC) inhibitor, totally blocked the LPO increment by PMA without any effect on the basal LPO in glomeruli, suggesting the involvement of PKC in LPO formation.	Tetradecanoylphorbol Acetate	112-115	protein kinase C, gamma	Rattus norvegicus	59-62
1510117-5	1992	Furthermore, sphingosine (100 microM), a protein kinase C (PKC) inhibitor, totally blocked the LPO increment by PMA without any effect on the basal LPO in glomeruli, suggesting the involvement of PKC in LPO formation.	Tetradecanoylphorbol Acetate	112-115	protein kinase C, gamma	Rattus norvegicus	196-199
12499080-4	2003	In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes.	Tetradecanoylphorbol Acetate	110-113	C-C motif chemokine ligand 2	Homo sapiens	145-150
1325152-10	1992	3 beta-HSD was not induced by cyclic AMP or TPA alone, but was induced by the combination of the two agents.	Tetradecanoylphorbol Acetate	44-47	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	0-10
12499080-4	2003	In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes.	Tetradecanoylphorbol Acetate	110-113	C-C motif chemokine ligand 2	Homo sapiens	191-196
12502859-9	2003	This association is specific, requiring the basic domain (amino acids 122 to 189) of K-bZIP and a specific region (amino acids 499 to 550) of K-Rta, and can be detected with K-bZIP and K-Rta endogenously expressed in BCBL-1 cells treated with tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	243-272	MAS related GPR family member F	Homo sapiens	144-147
1322709-4	1992	Phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C, stimulated synthesis of prostaglandins in Kupffer cells; PAF and PMA exerted additive actions on this process.	Tetradecanoylphorbol Acetate	33-36	PCNA clamp associated factor	Rattus norvegicus	130-133
12502859-9	2003	This association is specific, requiring the basic domain (amino acids 122 to 189) of K-bZIP and a specific region (amino acids 499 to 550) of K-Rta, and can be detected with K-bZIP and K-Rta endogenously expressed in BCBL-1 cells treated with tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	243-272	MAS related GPR family member F	Homo sapiens	187-190
14594325-9	2003	Preliminary results show that, among patients with short aPTTs, homozygosity for the hyperfibrinolytic PAI-1 5G or tPA I alleles are at increased risk of in-hospital mortality compared with 4G/4G PAI-1 and D/D tPA homozygotes (OR=2.6, 95% CI: 1.3-5.5 and OR=5.5, 95% CI: 1.3-24.5, respectively).	Tetradecanoylphorbol Acetate	115-118	serpin family E member 1	Homo sapiens	103-108
1535552-7	1992	Interestingly, 12-O-tetradecanoylphorbol-13-acetate transiently reduced CD45 protein-tyrosine phosphatase activity in the chronic myelogenous leukemia cell RWLeu4 without altering the CD45 amount (as measured by cell surface immunofluorescence).	Tetradecanoylphorbol Acetate	15-51	protein tyrosine phosphatase receptor type C	Homo sapiens	72-76
1616943-1	1992	The HGF-induced [Ca2+]i oscillations were suppressed by the pretreatment with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	78-109	hepatocyte growth factor	Rattus norvegicus	4-7
1616943-1	1992	The HGF-induced [Ca2+]i oscillations were suppressed by the pretreatment with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	111-114	hepatocyte growth factor	Rattus norvegicus	4-7
14594325-9	2003	Preliminary results show that, among patients with short aPTTs, homozygosity for the hyperfibrinolytic PAI-1 5G or tPA I alleles are at increased risk of in-hospital mortality compared with 4G/4G PAI-1 and D/D tPA homozygotes (OR=2.6, 95% CI: 1.3-5.5 and OR=5.5, 95% CI: 1.3-24.5, respectively).	Tetradecanoylphorbol Acetate	115-118	serpin family E member 1	Homo sapiens	196-201
14594325-9	2003	Preliminary results show that, among patients with short aPTTs, homozygosity for the hyperfibrinolytic PAI-1 5G or tPA I alleles are at increased risk of in-hospital mortality compared with 4G/4G PAI-1 and D/D tPA homozygotes (OR=2.6, 95% CI: 1.3-5.5 and OR=5.5, 95% CI: 1.3-24.5, respectively).	Tetradecanoylphorbol Acetate	210-213	serpin family E member 1	Homo sapiens	103-108
1317777-2	1992	The lectin Concanavalin-A (Con-A) and the activator of protein kinase-C tetradecanoylphorbol acetate (TPA) blunt the effects of elevated extracellular calcium (Ca2+) concentrations on several aspects of parathyroid function, including PTH release, the cytosolic calcium concentration, and the accumulation of cAMP and inositol phosphates.	Tetradecanoylphorbol Acetate	72-100	parathyroid hormone	Bos taurus	235-238
12419708-3	2002	Incubation of isolated membrane fractions suspended in Ca2+-free buffer with thrombin or phorbol 12-myristate 13-acetate resulted in a two- to threefold increase in iPLA2 activity.	Tetradecanoylphorbol Acetate	89-120	calcium-independent phospholipase A2-gamma	Oryctolagus cuniculus	165-170
1317777-2	1992	The lectin Concanavalin-A (Con-A) and the activator of protein kinase-C tetradecanoylphorbol acetate (TPA) blunt the effects of elevated extracellular calcium (Ca2+) concentrations on several aspects of parathyroid function, including PTH release, the cytosolic calcium concentration, and the accumulation of cAMP and inositol phosphates.	Tetradecanoylphorbol Acetate	102-105	parathyroid hormone	Bos taurus	235-238
1317777-4	1992	Con-A and TPA both enhanced PTH release by about 2-fold at 0.5-1 x 10(-4) M neomycin, concentrations that inhibited PTH release to an extent (40-50%) similar to that seen with high (1.5-2 mM) Ca2+.	Tetradecanoylphorbol Acetate	10-13	parathyroid hormone	Bos taurus	28-31
1317777-4	1992	Con-A and TPA both enhanced PTH release by about 2-fold at 0.5-1 x 10(-4) M neomycin, concentrations that inhibited PTH release to an extent (40-50%) similar to that seen with high (1.5-2 mM) Ca2+.	Tetradecanoylphorbol Acetate	10-13	parathyroid hormone	Bos taurus	116-119
1375896-4	1992	Uterine levels of c-fos mRNA observed after treatment with the phorbol ester phorbol 12-myristate 13-acetate are not decreased by a 3-h pretreatment with progesterone.	Tetradecanoylphorbol Acetate	77-108	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	18-23
1383560-0	1992	AP-1 complex and c-fos transcription are involved in TPA provoked and trans-synaptic inductions of the tyrosine hydroxylase gene: insights into long-term regulatory mechanisms.	Tetradecanoylphorbol Acetate	53-56	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	17-22
1321770-4	1992	Pretreatment of MCF-7 cells with TPA caused attenuation of both these BN-induced responses.	Tetradecanoylphorbol Acetate	33-36	gastrin releasing peptide	Homo sapiens	70-72
1321770-6	1992	Furthermore, putative down-regulation of PKC by prolonged TPA pretreatment also reversed the inhibitory action of TPA and enhanced BN-induced phosphoinositide hydrolysis.	Tetradecanoylphorbol Acetate	58-61	gastrin releasing peptide	Homo sapiens	131-133
1321770-7	1992	TPA also inhibited BN-induced increases in cytosolic Ca2+ concentration ([Ca2+]i) and caused a dose-dependent inhibition of epidermal growth factor (EGF) binding in MCF-7 cells.	Tetradecanoylphorbol Acetate	0-3	gastrin releasing peptide	Homo sapiens	19-21
1314821-1	1992	Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron.	Tetradecanoylphorbol Acetate	222-253	spindlin 1	Homo sapiens	19-23
1314821-1	1992	Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron.	Tetradecanoylphorbol Acetate	222-253	spindlin 1	Homo sapiens	34-38
1314821-1	1992	Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron.	Tetradecanoylphorbol Acetate	222-253	spindlin 1	Homo sapiens	34-38
1314824-6	1992	AUBF activity is very low in quiescent preadipocytes, but can be up-regulated by agonists such as TPA, TNF alpha, cAMP, and okadaic acid, all of which stabilize GLUT-1 mRNA.	Tetradecanoylphorbol Acetate	98-101	solute carrier family 2 member 1	Homo sapiens	161-167
1559232-5	1992	Sarp A significantly decreased the TPA-induced infiltration of neutrophils, the levels of myeloperoxidase in the dermis, and the formation of H2O2, cis-thymidine glycol, 8-hydroxyl-2"-deoxyguanosine, and 5-hydroxymethyl-2"-deoxyuridine in the epidermis.	Tetradecanoylphorbol Acetate	35-38	myeloperoxidase	Mus musculus	90-105
1313769-0	1992	Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.	Tetradecanoylphorbol Acetate	8-11	v-raf-leukemia viral oncogene 1	Mus musculus	81-86
1313769-2	1992	We show by use of Raf-1 dominant-negative mutants that Raf-1 is required for serum-, TPA-, and Ras-induced expression from the oncogene-responsive element in the polyomavirus enhancer.	Tetradecanoylphorbol Acetate	85-88	v-raf-leukemia viral oncogene 1	Mus musculus	18-23
1313769-2	1992	We show by use of Raf-1 dominant-negative mutants that Raf-1 is required for serum-, TPA-, and Ras-induced expression from the oncogene-responsive element in the polyomavirus enhancer.	Tetradecanoylphorbol Acetate	85-88	v-raf-leukemia viral oncogene 1	Mus musculus	55-60
1313769-4	1992	Raf-C4 appears to function by titrating out a Raf-1-activating factor that is induced by Ras following serum or TPA treatment of NIH-3T3 cells.	Tetradecanoylphorbol Acetate	112-115	v-raf-leukemia viral oncogene 1	Mus musculus	46-51
1371802-9	1992	Also, phorbol myristate acetate-induced homotypic adhesion of U937, which is ICAM-1 dependent, was markedly induced by these agents.	Tetradecanoylphorbol Acetate	6-31	intercellular adhesion molecule 1	Homo sapiens	77-83
1549364-0	1992	Regulation of the p58GTA cell division control-related protein kinase during phorbol 12-myristate 13-acetate-induced terminal differentiation of U937 cells.	Tetradecanoylphorbol Acetate	77-108	cyclin dependent kinase 11A	Homo sapiens	18-24
1549364-5	1992	Assays of p58GTA protein kinase activity show that, even though steady-state protein levels are relatively constant, protein kinase activity increases within 30 min of PMA treatment, and then peaks at 2 h and 12 h after PMA treatment.	Tetradecanoylphorbol Acetate	168-171	cyclin dependent kinase 11A	Homo sapiens	10-16
1371276-2	1992	Previous experiments have shown that heparin inhibits induction of c-fos and c-myc protooncogene mRNA in rat VSMC stimulated by phorbol 12-myristate 13-acetate (PMA) but not when stimulated by epidermal growth factor (EGF) (Pukac, L. A., Castellot, J. J., Wright, T. C., Caleb, B. L., and Karnovsky, M. J.	Tetradecanoylphorbol Acetate	128-159	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	67-72
1542579-1	1992	To understand the mechanism by which phorbol esters (PMA) stimulate c-jun transcription in human leukemic cell line U937, we have mutated specific enhancer sequences within the c-jun promoter.	Tetradecanoylphorbol Acetate	53-56	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-73
1542579-1	1992	To understand the mechanism by which phorbol esters (PMA) stimulate c-jun transcription in human leukemic cell line U937, we have mutated specific enhancer sequences within the c-jun promoter.	Tetradecanoylphorbol Acetate	53-56	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	177-182
1737349-6	1992	Down-regulation of PKC by prolonged pretreatment with 12-O-tetradecanoylphorbol-13-acetate was also associated with inhibition of CDDP-induced c-jun expression.	Tetradecanoylphorbol Acetate	54-90	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	143-148
1347198-9	1992	We conclude from these data that although PMA-induced ICAM-1 expression may be triggered through activation of protein kinase C, ICAM-1 induction by IL-1 beta, TNF-alpha, or LPS may involve distinct regulatory pathway(s).	Tetradecanoylphorbol Acetate	42-45	intercellular adhesion molecule 1	Homo sapiens	54-60
1347198-9	1992	We conclude from these data that although PMA-induced ICAM-1 expression may be triggered through activation of protein kinase C, ICAM-1 induction by IL-1 beta, TNF-alpha, or LPS may involve distinct regulatory pathway(s).	Tetradecanoylphorbol Acetate	42-45	intercellular adhesion molecule 1	Homo sapiens	129-135
1740006-1	1992	Previous work from our laboratory demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) or a synthetic diacylglycerol induced significantly higher epidermal ornithine decarboxylase (ODC) activity in C57BL/6 than in DBA/2 mice.	Tetradecanoylphorbol Acetate	52-88	ornithine decarboxylase, structural 1	Mus musculus	164-187
1740006-1	1992	Previous work from our laboratory demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) or a synthetic diacylglycerol induced significantly higher epidermal ornithine decarboxylase (ODC) activity in C57BL/6 than in DBA/2 mice.	Tetradecanoylphorbol Acetate	52-88	ornithine decarboxylase, structural 1	Mus musculus	189-192
1740006-1	1992	Previous work from our laboratory demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) or a synthetic diacylglycerol induced significantly higher epidermal ornithine decarboxylase (ODC) activity in C57BL/6 than in DBA/2 mice.	Tetradecanoylphorbol Acetate	90-93	ornithine decarboxylase, structural 1	Mus musculus	164-187
1740006-1	1992	Previous work from our laboratory demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) or a synthetic diacylglycerol induced significantly higher epidermal ornithine decarboxylase (ODC) activity in C57BL/6 than in DBA/2 mice.	Tetradecanoylphorbol Acetate	90-93	ornithine decarboxylase, structural 1	Mus musculus	189-192
1740006-3	1992	In addition, the ODC induction response in B6D2F1 offspring and BXD recombinant inbred (RI) strains was examined following multiple treatments with TPA.	Tetradecanoylphorbol Acetate	148-151	ornithine decarboxylase, structural 1	Mus musculus	17-20
1740006-7	1992	ODC activity induced by multiple application of TPA in B6DF1 mice, whose susceptibility to phorbol ester tumor promotion is inherited as an incomplete dominant trait, was comparable to that induced in C57BL/6 mice at all the doses examined.	Tetradecanoylphorbol Acetate	48-51	ornithine decarboxylase, structural 1	Mus musculus	0-3
1740006-8	1992	Cluster analysis of TPA-induced ODC activity in BXD RI strains allowed us tentatively to group them into four or five phenotypes and to estimate a minimum of two genetic loci controlling TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	20-23	ornithine decarboxylase, structural 1	Mus musculus	32-35
1740006-8	1992	Cluster analysis of TPA-induced ODC activity in BXD RI strains allowed us tentatively to group them into four or five phenotypes and to estimate a minimum of two genetic loci controlling TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	20-23	ornithine decarboxylase, structural 1	Mus musculus	199-202
1740006-8	1992	Cluster analysis of TPA-induced ODC activity in BXD RI strains allowed us tentatively to group them into four or five phenotypes and to estimate a minimum of two genetic loci controlling TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	187-190	ornithine decarboxylase, structural 1	Mus musculus	199-202
1537381-2	1992	Stimulation of the human T cell line Jurkat via the T cell receptor-CD3 complex with anti-CD3 monoclonal antibody or incubation with the tumor promoter phorbol 12-myristate 13-acetate caused increases in S6 kinase and microtubule-associated protein 2 (MAP) kinase activities.	Tetradecanoylphorbol Acetate	152-183	microtubule associated protein 2	Homo sapiens	218-250
1537381-2	1992	Stimulation of the human T cell line Jurkat via the T cell receptor-CD3 complex with anti-CD3 monoclonal antibody or incubation with the tumor promoter phorbol 12-myristate 13-acetate caused increases in S6 kinase and microtubule-associated protein 2 (MAP) kinase activities.	Tetradecanoylphorbol Acetate	152-183	microtubule associated protein 2	Homo sapiens	252-255
1370843-7	1992	TPA alone in the absence of CT and IBMX caused a dose-dependent stimulation of tyrosinase activity.	Tetradecanoylphorbol Acetate	0-3	tyrosinase	Homo sapiens	79-89
1370843-8	1992	Maximal tyrosinase activity was obtained in the presence of 0.8 nM TPA, 20 ng/ml CT, and 10(-4) M IBMX.	Tetradecanoylphorbol Acetate	67-70	tyrosinase	Homo sapiens	8-18
1576243-7	1992	Furthermore, LNC stimulated with ionomycin plus TPA were less susceptible to inhibition by pretreatment with TPA, most likely because this mitogenic combination caused a much greater amount of IL-2 mRNA than did Con A or Con A plus TPA.	Tetradecanoylphorbol Acetate	109-112	interleukin 2	Bos taurus	193-197
1576243-7	1992	Furthermore, LNC stimulated with ionomycin plus TPA were less susceptible to inhibition by pretreatment with TPA, most likely because this mitogenic combination caused a much greater amount of IL-2 mRNA than did Con A or Con A plus TPA.	Tetradecanoylphorbol Acetate	109-112	interleukin 2	Bos taurus	193-197
1576243-8	1992	Finally, a protein synthesis inhibitor, cycloheximide, partially counteracted the negative effects of TPA on IL-2 mRNA accumulation and on proliferation.	Tetradecanoylphorbol Acetate	102-105	interleukin 2	Bos taurus	109-113
1576243-9	1992	These results suggest that TPA, probably acting through protein kinase C, initially augments the production of IL-2 mRNA but subsequently induces mechanisms to decrease the level of mRNA.	Tetradecanoylphorbol Acetate	27-30	interleukin 2	Bos taurus	111-115
1372137-0	1992	Production of interleukin-2 mRNA by bovine lymph node lymphocytes in response to concanavalin A, 12-O-tetradecanoylphorbol-13-acetate, and ionomycin.	Tetradecanoylphorbol Acetate	97-133	interleukin 2	Bos taurus	14-27
1372137-4	1992	The dose-responses and time courses of the production of IL-2 mRNA in response to Concanavalin A (ConA), 12-O-tetradecanoylphorbol-13-acetate (TPA), and ionomycin in lymph node lymphocytes (LNC) were determined.	Tetradecanoylphorbol Acetate	105-141	interleukin 2	Bos taurus	57-61
1372137-4	1992	The dose-responses and time courses of the production of IL-2 mRNA in response to Concanavalin A (ConA), 12-O-tetradecanoylphorbol-13-acetate (TPA), and ionomycin in lymph node lymphocytes (LNC) were determined.	Tetradecanoylphorbol Acetate	143-146	interleukin 2	Bos taurus	57-61
1372137-5	1992	We found that high levels of IL-2 mRNA were produced in response to 1 microgram ml-1 ConA plus 10(-8) M TPA, but that even higher levels were produced in response to 1 microM ionomycin plus 10(-8) M TPA.	Tetradecanoylphorbol Acetate	104-107	interleukin 2	Bos taurus	29-33
1372137-5	1992	We found that high levels of IL-2 mRNA were produced in response to 1 microgram ml-1 ConA plus 10(-8) M TPA, but that even higher levels were produced in response to 1 microM ionomycin plus 10(-8) M TPA.	Tetradecanoylphorbol Acetate	199-202	interleukin 2	Bos taurus	29-33
1372137-8	1992	IL-2 mRNA was detected within 2 h of addition of ConA plus TPA (the earliest time examined), reached maximum levels within 6 h, and declined to low levels after 12 h. IL-2 mRNA from LNC incubated with ionomycin plus TPA appeared within 2 h, and reached maximum levels at about 9 h. In contrast to the decrease seen after 12 h with ConA plus TPA, IL-2 mRNA from these cells remained high for 18 h and declined to low levels after 24 h.	Tetradecanoylphorbol Acetate	59-62	interleukin 2	Bos taurus	0-4
1372137-8	1992	IL-2 mRNA was detected within 2 h of addition of ConA plus TPA (the earliest time examined), reached maximum levels within 6 h, and declined to low levels after 12 h. IL-2 mRNA from LNC incubated with ionomycin plus TPA appeared within 2 h, and reached maximum levels at about 9 h. In contrast to the decrease seen after 12 h with ConA plus TPA, IL-2 mRNA from these cells remained high for 18 h and declined to low levels after 24 h.	Tetradecanoylphorbol Acetate	216-219	interleukin 2	Bos taurus	0-4
1372137-8	1992	IL-2 mRNA was detected within 2 h of addition of ConA plus TPA (the earliest time examined), reached maximum levels within 6 h, and declined to low levels after 12 h. IL-2 mRNA from LNC incubated with ionomycin plus TPA appeared within 2 h, and reached maximum levels at about 9 h. In contrast to the decrease seen after 12 h with ConA plus TPA, IL-2 mRNA from these cells remained high for 18 h and declined to low levels after 24 h.	Tetradecanoylphorbol Acetate	216-219	interleukin 2	Bos taurus	167-171
1372137-8	1992	IL-2 mRNA was detected within 2 h of addition of ConA plus TPA (the earliest time examined), reached maximum levels within 6 h, and declined to low levels after 12 h. IL-2 mRNA from LNC incubated with ionomycin plus TPA appeared within 2 h, and reached maximum levels at about 9 h. In contrast to the decrease seen after 12 h with ConA plus TPA, IL-2 mRNA from these cells remained high for 18 h and declined to low levels after 24 h.	Tetradecanoylphorbol Acetate	216-219	interleukin 2	Bos taurus	167-171
1372137-8	1992	IL-2 mRNA was detected within 2 h of addition of ConA plus TPA (the earliest time examined), reached maximum levels within 6 h, and declined to low levels after 12 h. IL-2 mRNA from LNC incubated with ionomycin plus TPA appeared within 2 h, and reached maximum levels at about 9 h. In contrast to the decrease seen after 12 h with ConA plus TPA, IL-2 mRNA from these cells remained high for 18 h and declined to low levels after 24 h.	Tetradecanoylphorbol Acetate	216-219	interleukin 2	Bos taurus	0-4
1372137-8	1992	IL-2 mRNA was detected within 2 h of addition of ConA plus TPA (the earliest time examined), reached maximum levels within 6 h, and declined to low levels after 12 h. IL-2 mRNA from LNC incubated with ionomycin plus TPA appeared within 2 h, and reached maximum levels at about 9 h. In contrast to the decrease seen after 12 h with ConA plus TPA, IL-2 mRNA from these cells remained high for 18 h and declined to low levels after 24 h.	Tetradecanoylphorbol Acetate	216-219	interleukin 2	Bos taurus	167-171
1372137-8	1992	IL-2 mRNA was detected within 2 h of addition of ConA plus TPA (the earliest time examined), reached maximum levels within 6 h, and declined to low levels after 12 h. IL-2 mRNA from LNC incubated with ionomycin plus TPA appeared within 2 h, and reached maximum levels at about 9 h. In contrast to the decrease seen after 12 h with ConA plus TPA, IL-2 mRNA from these cells remained high for 18 h and declined to low levels after 24 h.	Tetradecanoylphorbol Acetate	216-219	interleukin 2	Bos taurus	167-171
1730078-2	1992	Media conditioned by phorbol myristate acetate (PMA)-stimulated murine bone marrow stromal cell lines, MC3T3-G2/PA6 and ST2, contained activin A/EDF, assayed as the activity inducing erythroid differentiation of an activin A/EDF-responsive murine erythroleukemia cell clone F5.	Tetradecanoylphorbol Acetate	21-46	interleukin 1 receptor-like 1	Mus musculus	120-123
1730078-2	1992	Media conditioned by phorbol myristate acetate (PMA)-stimulated murine bone marrow stromal cell lines, MC3T3-G2/PA6 and ST2, contained activin A/EDF, assayed as the activity inducing erythroid differentiation of an activin A/EDF-responsive murine erythroleukemia cell clone F5.	Tetradecanoylphorbol Acetate	48-51	interleukin 1 receptor-like 1	Mus musculus	120-123
1731522-5	1992	Within 48 hours after induction with phorbol ester (TPA), both parent lines exhibited markedly increased expression of c-fos/c-jun.	Tetradecanoylphorbol Acetate	52-55	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	119-124
1731522-5	1992	Within 48 hours after induction with phorbol ester (TPA), both parent lines exhibited markedly increased expression of c-fos/c-jun.	Tetradecanoylphorbol Acetate	52-55	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	125-130
1731522-14	1992	Expression of c-fos/c-jun also was noted in a subpopulation of H-RS cells in tissues; and this expression also was enhanced when these cells were treated with TPA in culture.	Tetradecanoylphorbol Acetate	159-162	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
1731522-14	1992	Expression of c-fos/c-jun also was noted in a subpopulation of H-RS cells in tissues; and this expression also was enhanced when these cells were treated with TPA in culture.	Tetradecanoylphorbol Acetate	159-162	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-25
1733573-0	1992	Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate.	Tetradecanoylphorbol Acetate	122-158	ornithine decarboxylase, structural 1	Mus musculus	13-36
1733573-1	1992	Single applications of 12-O-tetradecanoylphorbol-13-acetate (TPA), mezerein or ethyl phenylpropriolate (EPP) to mouse skin at appropriate doses cause similar degrees of hyperplasia and comparable levels of induction of epidermal ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	23-59	ornithine decarboxylase, structural 1	Mus musculus	229-252
1733573-1	1992	Single applications of 12-O-tetradecanoylphorbol-13-acetate (TPA), mezerein or ethyl phenylpropriolate (EPP) to mouse skin at appropriate doses cause similar degrees of hyperplasia and comparable levels of induction of epidermal ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	23-59	ornithine decarboxylase, structural 1	Mus musculus	254-257
1733573-2	1992	Multiple (n = 5) treatments with these agents, in contrast, resulted in large differences in induced ODC activity (TPA much greater than mezerein greater than EPP) with no differences in the degree of hyperplasia or [3H]thymidine pulse-labeling among the multiple treatment groups.	Tetradecanoylphorbol Acetate	115-118	ornithine decarboxylase, structural 1	Mus musculus	101-104
1733573-3	1992	To attempt to explain the cellular basis for the greater ODC-inducing ability of TPA relative to mezerein and EPP in chronic exposure protocols, immunocytochemical and flow cytometric analyses were performed.	Tetradecanoylphorbol Acetate	81-84	ornithine decarboxylase, structural 1	Mus musculus	57-60
1733573-8	1992	Our results suggest that chronic treatment of murine epidermis with the potent complete tumor promoter TPA leads to the selective expansion of a keratinocyte subpopulation that is hyperinducible for ODC and may be identical to the cells in the perifollicular region previously identified.	Tetradecanoylphorbol Acetate	103-106	ornithine decarboxylase, structural 1	Mus musculus	199-202
1571202-3	1992	In our first report, we characterized the rat lacrimal gland PKC along with a phorbol 12-myristate 13-acetate (PMA)-activated and phospholipid-independent protein kinase activity [Mauduit P., Zoukhri D. and Rossignol B.	Tetradecanoylphorbol Acetate	78-109	protein kinase C, gamma	Rattus norvegicus	61-64
12106305-1	1992	Protein kinase C (PKC) is a Ca2+-dependent enzyme involved in synaptic transmission, which can be experimentally activated by the phorbol ester, phorbol 12-myristate-13-acetate (TPA).	Tetradecanoylphorbol Acetate	145-176	protein kinase C, gamma	Rattus norvegicus	0-16
12106305-1	1992	Protein kinase C (PKC) is a Ca2+-dependent enzyme involved in synaptic transmission, which can be experimentally activated by the phorbol ester, phorbol 12-myristate-13-acetate (TPA).	Tetradecanoylphorbol Acetate	145-176	protein kinase C, gamma	Rattus norvegicus	18-21
12106305-1	1992	Protein kinase C (PKC) is a Ca2+-dependent enzyme involved in synaptic transmission, which can be experimentally activated by the phorbol ester, phorbol 12-myristate-13-acetate (TPA).	Tetradecanoylphorbol Acetate	178-181	protein kinase C, gamma	Rattus norvegicus	0-16
12106305-1	1992	Protein kinase C (PKC) is a Ca2+-dependent enzyme involved in synaptic transmission, which can be experimentally activated by the phorbol ester, phorbol 12-myristate-13-acetate (TPA).	Tetradecanoylphorbol Acetate	178-181	protein kinase C, gamma	Rattus norvegicus	18-21
12106305-9	1992	In particular, since mean quantum size and release probability remained almost unchanged during TPA facilitation, it was concluded that PKC acted by enlarging the immediately available store.	Tetradecanoylphorbol Acetate	96-99	protein kinase C, gamma	Rattus norvegicus	136-139
1727760-5	1992	Receptor-independent stimulation of protein kinase C by the phorbol ester beta-phorbol-12-myristate-13-acetate caused significant CCK release.	Tetradecanoylphorbol Acetate	74-110	cholecystokinin	Canis lupus familiaris	130-133
1335967-4	1992	PKA activity was increased by exposing cultured astrocytes to forskolin or dibutyryl cyclic AMP, whereas PKC activity was stimulated with phorbol-12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	138-169	protein kinase C, gamma	Rattus norvegicus	105-108
1335967-4	1992	PKA activity was increased by exposing cultured astrocytes to forskolin or dibutyryl cyclic AMP, whereas PKC activity was stimulated with phorbol-12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	171-174	protein kinase C, gamma	Rattus norvegicus	105-108
1284126-4	1992	In contrast, MMP-3, MMP-9 and TIMP-1 activities were markedly stimulated by TPA in most of the tumor cell lines and human umbilical vein endothelial cells (HUVEC), whereas the fibroblast lines were minimally stimulated or unresponsive to TPA.	Tetradecanoylphorbol Acetate	76-79	matrix metallopeptidase 9	Homo sapiens	20-25
1284126-10	1992	Exceptions were the fibroblast cell lines which showed either a much more marked mRNA response of MMP-9 to TPA than observed at protein level, or a high constitutive MMP-9 mRNA when MMP-9 activity was not detectable by zymography.	Tetradecanoylphorbol Acetate	107-110	matrix metallopeptidase 9	Homo sapiens	98-103
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	28-33
1284126-13	1992	TPA treatment caused the increased expression of c-fos containing AP-1-specific binding activity in selected tumor cell lines.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-54
1284126-14	1992	This activity was maximal at 6 h. An association was observed between AP-1 binding activity and increased expression of MMP-1, MMP-3 and MMP-9, which possess TPA-responsive elements (TRE).	Tetradecanoylphorbol Acetate	158-161	matrix metallopeptidase 9	Homo sapiens	137-142
1662217-0	1991	Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues.	Tetradecanoylphorbol Acetate	12-48	myelin basic protein	Oryctolagus cuniculus	92-112
1662217-0	1991	Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues.	Tetradecanoylphorbol Acetate	12-48	microtubule-associated protein 2	Oryctolagus cuniculus	113-145
1662217-0	1991	Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues.	Tetradecanoylphorbol Acetate	12-48	microtubule-associated protein 2	Oryctolagus cuniculus	151-155
1764695-3	1991	It was observed that TA inhibited TPA induced ODC activity.	Tetradecanoylphorbol Acetate	34-37	ornithine decarboxylase, structural 1	Mus musculus	46-49
1659520-4	1991	12-O-Tetradecanoyl-phorbol-13-acetate (TPA; 50-400 ng/ml) and 1-oleoyl-2-acetylglycerol (OAG; 1-75 micrograms/ml) mimicked the actions of EGF by inducing a concentration-dependent increase in pHi which reached a maximum of 0.25-0.30 pH units.	Tetradecanoylphorbol Acetate	0-37	epidermal growth factor	Gallus gallus	138-141
1659520-7	1991	Like EGF-induced cytosolic alkalinization, the increases in pHi in response to TPA or OAG were dependent on the presence of sodium concentration and were inhibited by amiloride, an inhibitor of the Na+/H+ antiporter.	Tetradecanoylphorbol Acetate	79-82	epidermal growth factor	Gallus gallus	5-8
1659520-9	1991	Down-regulation of granulosa cell PKC by pretreatment with TPA (200 ng/ml) for 2.5 h inhibited EGF-, TPA-, and OAG-induced cytosolic alkalinization.	Tetradecanoylphorbol Acetate	59-62	epidermal growth factor	Gallus gallus	95-98
1838006-8	1991	The CD45 deficient cells secreted highly reduced levels of lymphokines (IL-2, IL-3 or GM-CSF) after activation by anti-CD3 mAb combined with the phorbol ester TPA.	Tetradecanoylphorbol Acetate	159-162	protein tyrosine phosphatase receptor type C	Homo sapiens	4-8
1720402-0	1991	Phorbol 12-myristate-13-acetate (PMA) stimulates a differential expression of cholecystokinin (CCK) and c-fos mRNA in a human neuroblastoma cell line.	Tetradecanoylphorbol Acetate	0-31	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-109
1741758-4	1991	PC12 cells were "down-regulated" by prior treatment (24 h) with phorbol 12-myristate 13-acetate (PMA; 1 microM), which nearly abolished endogenous PKC activity.	Tetradecanoylphorbol Acetate	64-95	protein kinase C, alpha	Rattus norvegicus	147-150
1741758-4	1991	PC12 cells were "down-regulated" by prior treatment (24 h) with phorbol 12-myristate 13-acetate (PMA; 1 microM), which nearly abolished endogenous PKC activity.	Tetradecanoylphorbol Acetate	97-100	protein kinase C, alpha	Rattus norvegicus	147-150
1833215-7	1991	Third, the combination of bFGF and PMA induced a stimulated PLA2-catalyzed release of arachidonic acid in HUVE cells.	Tetradecanoylphorbol Acetate	35-38	phospholipase A2 group IIA	Homo sapiens	60-64
1913689-2	1991	The aim of this study was to investigate the in vitro effects of 12-O-tetradecanoylphorbol-13-acetate used as a differentiation inducer on the CD30, t(5;6)(q35;p21) DEL cell line, taken to be a reliable representative of the human malignant histiocytosis cell line.	Tetradecanoylphorbol Acetate	65-101	TNF receptor superfamily member 8	Homo sapiens	143-147
1913689-3	1991	Treatment of DEL cells with 33 nM 12-O-tetradecanoylphorbol-13-acetate for 6-24 h resulted in cell surface attachment (up to 80%), decrease in dividing ability, enhancement of nitro blue tetrazolium reducing capacity (from 8 to 42%), occurrence of a limited immunodependent phagocytosis, and transient increase in expression of tumor necrosis factor alpha gene and in production of tumor necrosis factor alpha protein, whereas tumor necrosis factor beta remained undetectable.	Tetradecanoylphorbol Acetate	34-70	lymphotoxin alpha	Homo sapiens	427-453
1336558-5	1992	Serum as well as 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulated NGF and all 4 BDNF mRNAs in L929 cells.	Tetradecanoylphorbol Acetate	17-54	nerve growth factor	Mus musculus	72-75
1336558-5	1992	Serum as well as 12-O-tetradecanoyl phorbol-13-acetate (TPA) stimulated NGF and all 4 BDNF mRNAs in L929 cells.	Tetradecanoylphorbol Acetate	56-59	nerve growth factor	Mus musculus	72-75
1426252-5	1992	Various PKC pseudosubstrate peptides are phosphorylated by PKC-eta in a phospholipid and TPA-dependent but calcium-independent manner.	Tetradecanoylphorbol Acetate	89-92	protein kinase C, alpha	Rattus norvegicus	8-11
1394224-6	1992	The decrease in K-ras expression was greater for TPA-treated cells than for 1-beta-arabinofuranosylcytosine-treated cells.	Tetradecanoylphorbol Acetate	49-52	KRAS proto-oncogene, GTPase	Homo sapiens	16-21
1472905-3	1992	This report describes the sequential changes in the expression of four proto-oncogenes, c-fos, c-myc, c-sis and H-ras in DMEC following PMA exposure.	Tetradecanoylphorbol Acetate	136-139	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	88-93
1472905-3	1992	This report describes the sequential changes in the expression of four proto-oncogenes, c-fos, c-myc, c-sis and H-ras in DMEC following PMA exposure.	Tetradecanoylphorbol Acetate	136-139	platelet derived growth factor subunit B	Homo sapiens	102-107
1330491-10	1992	c-fos mRNA was induced by treatment with 50 ng/ml tetradecanoyl phorbol acetate or by 40 ng/ml forskolin, while induction of Egr-1 mRNA was stimulated by treatment with tetradecanoyl phorbol acetate, but not forskolin.	Tetradecanoylphorbol Acetate	50-79	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
1402922-6	1992	Although a protein kinase C (PKC) inhibitor, staurosporine (5 microM), blocked PMA-induced [3H]PEt formation by 77%, it had no effect on the CCh-induced formation.	Tetradecanoylphorbol Acetate	79-82	protein kinase C, gamma	Rattus norvegicus	11-27
1402922-6	1992	Although a protein kinase C (PKC) inhibitor, staurosporine (5 microM), blocked PMA-induced [3H]PEt formation by 77%, it had no effect on the CCh-induced formation.	Tetradecanoylphorbol Acetate	79-82	protein kinase C, gamma	Rattus norvegicus	29-32
1282220-2	1992	Activators of PKC, such as phorbol 12-myristate 13-acetate (PMA), mezerein and oleoyl acetylglycerol produced a concentration-dependent potentiation of K(+)-induced release of [3H]5-hydroxytryptamine ([3H]5-HT).	Tetradecanoylphorbol Acetate	27-58	protein kinase C, gamma	Rattus norvegicus	14-17
1282220-2	1992	Activators of PKC, such as phorbol 12-myristate 13-acetate (PMA), mezerein and oleoyl acetylglycerol produced a concentration-dependent potentiation of K(+)-induced release of [3H]5-hydroxytryptamine ([3H]5-HT).	Tetradecanoylphorbol Acetate	60-63	protein kinase C, gamma	Rattus norvegicus	14-17
1282220-7	1992	Similarly, the PKC inhibitors, polymyxin B and staurosporine, blocked effects of both PMA and Bay K 8644 on K(+)-stimulated release of [3H]5-HT.	Tetradecanoylphorbol Acetate	86-89	protein kinase C, gamma	Rattus norvegicus	15-18
1331936-1	1992	The product of the c-jun proto-oncogene is the major component of the 12-O-tetradecanoyl phorbol 13-acetate (TPA)-inducible transcription factor AP-1.	Tetradecanoylphorbol Acetate	70-107	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	19-24
1331936-1	1992	The product of the c-jun proto-oncogene is the major component of the 12-O-tetradecanoyl phorbol 13-acetate (TPA)-inducible transcription factor AP-1.	Tetradecanoylphorbol Acetate	70-107	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	145-149
1331936-1	1992	The product of the c-jun proto-oncogene is the major component of the 12-O-tetradecanoyl phorbol 13-acetate (TPA)-inducible transcription factor AP-1.	Tetradecanoylphorbol Acetate	109-112	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	19-24
1331936-1	1992	The product of the c-jun proto-oncogene is the major component of the 12-O-tetradecanoyl phorbol 13-acetate (TPA)-inducible transcription factor AP-1.	Tetradecanoylphorbol Acetate	109-112	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	145-149
1331936-2	1992	Jun binds to the TPA-responsive elements (TREs) present in a large number of TPA-inducible genes, thereby regulating their expression in response to activation of protein kinase C. Previously we have shown that Jun/AP-1 can also activate cAMP-responsive elements (CREs), indicating the existence of cross-talk in signal transduction at the transcriptional level.	Tetradecanoylphorbol Acetate	17-20	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	215-219
1331936-2	1992	Jun binds to the TPA-responsive elements (TREs) present in a large number of TPA-inducible genes, thereby regulating their expression in response to activation of protein kinase C. Previously we have shown that Jun/AP-1 can also activate cAMP-responsive elements (CREs), indicating the existence of cross-talk in signal transduction at the transcriptional level.	Tetradecanoylphorbol Acetate	77-80	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	215-219
1416623-4	1992	Because agonist-induced modulations in the rate of synthesis of tPA and ET have been associated with the Fos and Jun protein families, it seems reasonable to propose that genetic expression in shear stress- or mechanical strain-stimulated endothelial cells is also regulated by selective induction of fos and jun gene products.	Tetradecanoylphorbol Acetate	64-67	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-108
1416623-4	1992	Because agonist-induced modulations in the rate of synthesis of tPA and ET have been associated with the Fos and Jun protein families, it seems reasonable to propose that genetic expression in shear stress- or mechanical strain-stimulated endothelial cells is also regulated by selective induction of fos and jun gene products.	Tetradecanoylphorbol Acetate	64-67	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	301-304
1421569-3	1992	Phosphorylation of serine 243 markedly decreases the binding of c-Jun to oligonucleotides containing the 12-O-tetradecanoylphorbol-13-acetate response element.	Tetradecanoylphorbol Acetate	105-141	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	64-69
1355672-8	1992	FMLP-induced neutrophil aggregation was inhibited by 39.8% +/- 11.5% and 44.8% +/- 12.3%, respectively, by MoAbs to CD18 and CD11b (P less than .0005, n = 4 for both); a similar effect was demonstrated on TPA-induced aggregation.	Tetradecanoylphorbol Acetate	205-208	integrin subunit alpha M	Homo sapiens	125-130
1511903-1	1992	We report here the nucleotide sequence of a rat TIS11 cDNA, an immediate early gene, induced by nerve growth factor and epidermal growth factor, by 12-O-tetradecanoyl phorbol-13-acetate, and other stimuli in PC12 pheochromocytoma cells.	Tetradecanoylphorbol Acetate	148-185	zinc finger protein 36	Rattus norvegicus	48-53
1494907-6	1992	Conversely, 12-O-tetradecanoylphorbol 13-acetate, a protein kinase C activator, increased CSF-1 mRNA levels.	Tetradecanoylphorbol Acetate	12-48	colony stimulating factor 1 (macrophage)	Mus musculus	90-95
1501272-9	1992	One, which we designated SF1, is a ubiquitous basal factor, and the other, SF2, is a T-cell-predominant phorbol myristate acetate-inducible factor.	Tetradecanoylphorbol Acetate	104-129	serine and arginine rich splicing factor 1	Homo sapiens	75-78
1525051-6	1992	This may be caused by the lack of induction of genes from the jun family, whose gene products are necessary for dimerization with the c-fos encoded protein, leading to an important step in growth factor signalling pathways; stimulation of TPA responsive element (TRE)-dependent transcriptional activity.	Tetradecanoylphorbol Acetate	239-242	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-139
1386920-2	1992	We found that mutant Ras blocks serum- and 12-O-tetradecanoyl phorbol 13-acetate-induced activation of Raf-1 kinase in NIH3T3 cells and Raf-1 as well as B-Raf PSK stimulation by nerve growth factor (NGF) in PC12 pheochromocytoma cells.	Tetradecanoylphorbol Acetate	43-80	v-raf-leukemia viral oncogene 1	Mus musculus	103-108
1386920-2	1992	We found that mutant Ras blocks serum- and 12-O-tetradecanoyl phorbol 13-acetate-induced activation of Raf-1 kinase in NIH3T3 cells and Raf-1 as well as B-Raf PSK stimulation by nerve growth factor (NGF) in PC12 pheochromocytoma cells.	Tetradecanoylphorbol Acetate	43-80	v-raf-leukemia viral oncogene 1	Mus musculus	136-141
1520339-3	1992	A single topical application of 12-O-tetradecanoylphorbol-13-acetate induced a much more profound and longer-lasting increase in transgene-derived ornithine decarboxylase activity in comparison with the endogenous enzyme activity.	Tetradecanoylphorbol Acetate	32-68	ornithine decarboxylase, structural 1	Mus musculus	147-170
1327204-7	1992	We report that the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA), which impaired granulosa cell differentiation, also abolished the RII beta synthesis induced by FSH.	Tetradecanoylphorbol Acetate	52-88	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	19-33
1327204-7	1992	We report that the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA), which impaired granulosa cell differentiation, also abolished the RII beta synthesis induced by FSH.	Tetradecanoylphorbol Acetate	90-93	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	19-33
1390239-9	1992	In two cases in which CD41 was not expressed before culture, the expression of CD41 was enhanced after culture with or without 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	127-164	integrin subunit alpha 2b	Homo sapiens	79-83
1390239-9	1992	In two cases in which CD41 was not expressed before culture, the expression of CD41 was enhanced after culture with or without 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	166-169	integrin subunit alpha 2b	Homo sapiens	79-83
1629631-5	1992	ODC activity was elevated in all treatment groups (TPA greater than EPP greater than UVR), with UVR induction returning to near control (acetone) levels by 16 weeks even though the UVR-induced hyperplasia continued to increase at the 16-week point.	Tetradecanoylphorbol Acetate	51-54	ornithine decarboxylase, structural 1	Mus musculus	0-3
1321269-1	1992	The Epstein-Barr virus BZLF1 protein that can induce the lytic cycle in latently infected cells is a transcription factor partially homologous to Fos and binds not only the canonical TPA (tetradecanoyl phorbol acetate)-responsive element (TRE) site but also sequences deviating from the TRE consensus sequence.	Tetradecanoylphorbol Acetate	183-186	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	146-149
1321269-1	1992	The Epstein-Barr virus BZLF1 protein that can induce the lytic cycle in latently infected cells is a transcription factor partially homologous to Fos and binds not only the canonical TPA (tetradecanoyl phorbol acetate)-responsive element (TRE) site but also sequences deviating from the TRE consensus sequence.	Tetradecanoylphorbol Acetate	188-217	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	146-149
1380176-2	1992	Phorbol myristate acetate, which is known to activate PKC, was able to mimic TNF alpha-induced up-regulation of ICAM-1 and partly also VCAM-1 expression.	Tetradecanoylphorbol Acetate	0-25	intercellular adhesion molecule 1	Homo sapiens	112-118
1379048-1	1992	The precursor of matrix metalloproteinase 9 (proMMP-9), also known as "92 kDa progelatinase/type IV procollagenase", was purified from the conditioned medium of U937 monocytic leukaemia and HT1080 fibrosarcoma cell lines stimulated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	237-268	matrix metallopeptidase 9	Homo sapiens	17-43
1617628-6	1992	In the present study we assessed the effect of skin application of GTP to SENCAR mice on 12-O-tetradecanoylphorbol-13-acetate (TPA) and other skin tumor promoter-caused induction of epidermal ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	89-125	ornithine decarboxylase, structural 1	Mus musculus	217-220
1617628-7	1992	Topical application of GTP to mouse skin inhibited TPA-induced epidermal ODC activity in a dose-dependent manner.	Tetradecanoylphorbol Acetate	51-54	ornithine decarboxylase, structural 1	Mus musculus	73-76
1617628-11	1992	In order to identify which of the specific epicatechin derivatives present in GTP is responsible for these inhibitory effects, they were isolated from GTP and evaluated for their inhibitory effects against TPA-caused induction of epidermal ODC activity.	Tetradecanoylphorbol Acetate	206-209	ornithine decarboxylase, structural 1	Mus musculus	240-243
1617628-13	1992	EGCG also showed greater inhibitory effects against TPA-caused induction of epidermal ODC activity when compared with several other naturally occurring polyphenols.	Tetradecanoylphorbol Acetate	52-55	ornithine decarboxylase, structural 1	Mus musculus	86-89
1638676-11	1992	These data demonstrate an irreversible decrease in and alteration of the subcellular distribution of PKC-alpha and beta 2 in DMBA-initiated/TPA-promoted papillomas.	Tetradecanoylphorbol Acetate	140-143	hemoglobin, beta adult minor chain	Mus musculus	115-121
1665733-4	1991	Pretreatment of BAEC with 4 beta-phorbol 12-myristate 13-acetate (PMA; 100 nM) reduced the magnitude of the initial transient elevation of [Ca2+]i, induced by thrombin (1 mu ml-1), low concentrations of bradykinin (1 nM) or ATP (0.3 microM, 3 microM), but not by higher concentrations of the latter two agonists.	Tetradecanoylphorbol Acetate	26-64	coagulation factor II, thrombin	Bos taurus	159-167
1665733-4	1991	Pretreatment of BAEC with 4 beta-phorbol 12-myristate 13-acetate (PMA; 100 nM) reduced the magnitude of the initial transient elevation of [Ca2+]i, induced by thrombin (1 mu ml-1), low concentrations of bradykinin (1 nM) or ATP (0.3 microM, 3 microM), but not by higher concentrations of the latter two agonists.	Tetradecanoylphorbol Acetate	26-64	kininogen 1	Bos taurus	203-213
1665733-4	1991	Pretreatment of BAEC with 4 beta-phorbol 12-myristate 13-acetate (PMA; 100 nM) reduced the magnitude of the initial transient elevation of [Ca2+]i, induced by thrombin (1 mu ml-1), low concentrations of bradykinin (1 nM) or ATP (0.3 microM, 3 microM), but not by higher concentrations of the latter two agonists.	Tetradecanoylphorbol Acetate	66-69	coagulation factor II, thrombin	Bos taurus	159-167
1665733-4	1991	Pretreatment of BAEC with 4 beta-phorbol 12-myristate 13-acetate (PMA; 100 nM) reduced the magnitude of the initial transient elevation of [Ca2+]i, induced by thrombin (1 mu ml-1), low concentrations of bradykinin (1 nM) or ATP (0.3 microM, 3 microM), but not by higher concentrations of the latter two agonists.	Tetradecanoylphorbol Acetate	66-69	kininogen 1	Bos taurus	203-213
1665733-5	1991	Addition of PMA (100 nM) during the plateau phase of the increase in [Ca2+]i induced by thrombin (1 mu ml-1), bradykinin (10 nM) or ATP (30 microM) resulted in a fall in [Ca2+]i.	Tetradecanoylphorbol Acetate	12-15	coagulation factor II, thrombin	Bos taurus	88-96
1665733-5	1991	Addition of PMA (100 nM) during the plateau phase of the increase in [Ca2+]i induced by thrombin (1 mu ml-1), bradykinin (10 nM) or ATP (30 microM) resulted in a fall in [Ca2+]i.	Tetradecanoylphorbol Acetate	12-15	kininogen 1	Bos taurus	110-120
12183077-5	2002	ML-1 cells treated with KH1060 alone increased translocation of PKC theta, whereas cells treated with TPA alone increased translocation of PKC alpha and PKC epsilon.	Tetradecanoylphorbol Acetate	102-105	protein kinase C epsilon	Homo sapiens	153-164
1655395-8	1991	12-O-Tetradecanolylphorbol 13-acetate (TPA), a stimulator of PKC was indeed able to increase intracellular cAMP; this effect was not additive with that of AII.	Tetradecanoylphorbol Acetate	39-42	protein kinase C, gamma	Rattus norvegicus	61-64
1655395-9	1991	conversely, application of the PKC inhibitors H7 [1-(5-isoquinolylsulfonyl)2-methyl-piperazine] and staurosporine or desensitization of PKC by long exposure of the cells to TPA abolished the cAMP response to TPA as well as that to AII.	Tetradecanoylphorbol Acetate	173-176	protein kinase C, gamma	Rattus norvegicus	31-34
1655395-9	1991	conversely, application of the PKC inhibitors H7 [1-(5-isoquinolylsulfonyl)2-methyl-piperazine] and staurosporine or desensitization of PKC by long exposure of the cells to TPA abolished the cAMP response to TPA as well as that to AII.	Tetradecanoylphorbol Acetate	173-176	protein kinase C, gamma	Rattus norvegicus	136-139
1516571-4	1992	The potent PKC activator phorbol myristate acetate (PMA) stimulated dose-dependent increases in free AA levels in both day 2 and day 7 cultures, with optimal stimulation at 50 nM.	Tetradecanoylphorbol Acetate	25-50	protein kinase C, gamma	Rattus norvegicus	11-14
1516571-4	1992	The potent PKC activator phorbol myristate acetate (PMA) stimulated dose-dependent increases in free AA levels in both day 2 and day 7 cultures, with optimal stimulation at 50 nM.	Tetradecanoylphorbol Acetate	52-55	protein kinase C, gamma	Rattus norvegicus	11-14
1516571-8	1992	That the capacity of PMA to modulate AA metabolism was mediated by activation of PKC was confirmed by demonstrating that (1) phorbol didecanoate, which lacks the ability to activate PKC, failed to activate AA metabolism; (2) pretreatment for 18 h with 1 microM PMA, which depletes cellular PKC, abolished subsequent AA metabolism activated by 50 nM PMA; and (3) the PKC inhibitor staurosporine abrogated increases in the quantities of both free AA and prostaglandin E2 in response to PMA.	Tetradecanoylphorbol Acetate	21-24	protein kinase C, gamma	Rattus norvegicus	81-84
1516571-8	1992	That the capacity of PMA to modulate AA metabolism was mediated by activation of PKC was confirmed by demonstrating that (1) phorbol didecanoate, which lacks the ability to activate PKC, failed to activate AA metabolism; (2) pretreatment for 18 h with 1 microM PMA, which depletes cellular PKC, abolished subsequent AA metabolism activated by 50 nM PMA; and (3) the PKC inhibitor staurosporine abrogated increases in the quantities of both free AA and prostaglandin E2 in response to PMA.	Tetradecanoylphorbol Acetate	21-24	protein kinase C, gamma	Rattus norvegicus	182-185
1516571-8	1992	That the capacity of PMA to modulate AA metabolism was mediated by activation of PKC was confirmed by demonstrating that (1) phorbol didecanoate, which lacks the ability to activate PKC, failed to activate AA metabolism; (2) pretreatment for 18 h with 1 microM PMA, which depletes cellular PKC, abolished subsequent AA metabolism activated by 50 nM PMA; and (3) the PKC inhibitor staurosporine abrogated increases in the quantities of both free AA and prostaglandin E2 in response to PMA.	Tetradecanoylphorbol Acetate	21-24	protein kinase C, gamma	Rattus norvegicus	182-185
1516571-8	1992	That the capacity of PMA to modulate AA metabolism was mediated by activation of PKC was confirmed by demonstrating that (1) phorbol didecanoate, which lacks the ability to activate PKC, failed to activate AA metabolism; (2) pretreatment for 18 h with 1 microM PMA, which depletes cellular PKC, abolished subsequent AA metabolism activated by 50 nM PMA; and (3) the PKC inhibitor staurosporine abrogated increases in the quantities of both free AA and prostaglandin E2 in response to PMA.	Tetradecanoylphorbol Acetate	21-24	protein kinase C, gamma	Rattus norvegicus	182-185
1516571-8	1992	That the capacity of PMA to modulate AA metabolism was mediated by activation of PKC was confirmed by demonstrating that (1) phorbol didecanoate, which lacks the ability to activate PKC, failed to activate AA metabolism; (2) pretreatment for 18 h with 1 microM PMA, which depletes cellular PKC, abolished subsequent AA metabolism activated by 50 nM PMA; and (3) the PKC inhibitor staurosporine abrogated increases in the quantities of both free AA and prostaglandin E2 in response to PMA.	Tetradecanoylphorbol Acetate	261-264	protein kinase C, gamma	Rattus norvegicus	81-84
1655395-9	1991	conversely, application of the PKC inhibitors H7 [1-(5-isoquinolylsulfonyl)2-methyl-piperazine] and staurosporine or desensitization of PKC by long exposure of the cells to TPA abolished the cAMP response to TPA as well as that to AII.	Tetradecanoylphorbol Acetate	208-211	protein kinase C, gamma	Rattus norvegicus	31-34
1655395-9	1991	conversely, application of the PKC inhibitors H7 [1-(5-isoquinolylsulfonyl)2-methyl-piperazine] and staurosporine or desensitization of PKC by long exposure of the cells to TPA abolished the cAMP response to TPA as well as that to AII.	Tetradecanoylphorbol Acetate	208-211	protein kinase C, gamma	Rattus norvegicus	136-139
1893970-1	1991	The human cell line CMK spontaneously expresses megakaryocytic characteristics and can be induced to differentiate into mature megakaryocytes after exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	160-196	cytidine/uridine monophosphate kinase 1	Homo sapiens	20-23
1388136-11	1992	Moreover, the combined effects of TPA and ionomycin on T-cell function and cell-surface antigen expression appear to be due, at least in part, to their synergistic activation of distinct PKC isoenzyme(s).	Tetradecanoylphorbol Acetate	34-37	CD53 molecule	Homo sapiens	75-95
12498806-4	2002	Importantly, only the VLA-1(+) MC from PB and SF adhered to collagen IV upon triggering with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	93-124	integrin subunit alpha 1	Homo sapiens	22-27
1534852-4	1992	We also found that binding of the CREB-like factor to the 21-bp core element was enhanced by treatment with TPA, with little effect on transcriptional activity; in contrast, forskolin and p40tax did not facilitate binding, though they enhanced transcription.	Tetradecanoylphorbol Acetate	108-111	cAMP responsive element binding protein 1	Homo sapiens	34-38
1893970-1	1991	The human cell line CMK spontaneously expresses megakaryocytic characteristics and can be induced to differentiate into mature megakaryocytes after exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	198-201	cytidine/uridine monophosphate kinase 1	Homo sapiens	20-23
12414531-2	2002	Using antibodies to detect human or rat C5a, incubation at pH 7.4 of human blood neutrophils or rat alveolar macrophages (AMs) with C5 in the presence of phorbol 12-myristate 13-acetate (PMA) led to generation of C5a.	Tetradecanoylphorbol Acetate	154-185	complement C5	Rattus norvegicus	213-216
1893970-8	1991	CMK cells exhibited mRNA for GPIIb, and its expression was augmented by TPA addition, but not PF4.	Tetradecanoylphorbol Acetate	72-75	cytidine/uridine monophosphate kinase 1	Homo sapiens	0-3
1893970-8	1991	CMK cells exhibited mRNA for GPIIb, and its expression was augmented by TPA addition, but not PF4.	Tetradecanoylphorbol Acetate	72-75	integrin subunit alpha 2b	Homo sapiens	29-34
1893970-9	1991	In contrast, CMK11-5 cells were found to contain mRNA for GPIIb and PF4, and their mRNA levels were increased by the addition of TPA.	Tetradecanoylphorbol Acetate	129-132	integrin subunit alpha 2b	Homo sapiens	58-63
1635552-10	1992	When PKC activity was down-regulated by prolonged exposure to phorbol myristate acetate, PC12 cells responded to staurosporine with neurite outgrowth similar to that of untreated cells.	Tetradecanoylphorbol Acetate	62-87	protein kinase C, gamma	Rattus norvegicus	5-8
1320299-8	1992	Neutrophil superoxide anion production (O2-) was assessed in a kinetic fashion (in nanomoles per minute) by superoxide dismutase-inhibitable cytochrome C reduction (phorbol myristate acetate stimulation).	Tetradecanoylphorbol Acetate	165-190	cytochrome c	Sus scrofa	141-153
12423348-12	2002	Stimulation with tetradecanoyl phorbol acetate, causing monocytic differentiation, also resulted in down-regulation (two fold to threefold) of cystatin F expression, whereas the cystatin C expression was essentially unaltered in both experiments.	Tetradecanoylphorbol Acetate	17-46	cystatin F	Homo sapiens	143-153
1320001-6	1992	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) did not cause an increase in osteocalcin secretion, while only a small increase in cellular content of osteocalcin in ROS 17/2.8 cells was observed.	Tetradecanoylphorbol Acetate	23-54	protein kinase C, gamma	Rattus norvegicus	14-17
1320001-6	1992	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) did not cause an increase in osteocalcin secretion, while only a small increase in cellular content of osteocalcin in ROS 17/2.8 cells was observed.	Tetradecanoylphorbol Acetate	56-59	protein kinase C, gamma	Rattus norvegicus	14-17
1939341-1	1991	Previous studies have shown that treatment of human myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of monocytic differentiation and expression of the c-jun and c-fos early response genes.	Tetradecanoylphorbol Acetate	80-116	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	203-208
1939341-1	1991	Previous studies have shown that treatment of human myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of monocytic differentiation and expression of the c-jun and c-fos early response genes.	Tetradecanoylphorbol Acetate	80-116	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	213-218
1939341-1	1991	Previous studies have shown that treatment of human myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of monocytic differentiation and expression of the c-jun and c-fos early response genes.	Tetradecanoylphorbol Acetate	118-121	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	203-208
1939341-1	1991	Previous studies have shown that treatment of human myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of monocytic differentiation and expression of the c-jun and c-fos early response genes.	Tetradecanoylphorbol Acetate	118-121	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	213-218
1939341-2	1991	The present work demonstrates that the glucocorticoid dexamethasone inhibits TPA-induced increases in c-jun and c-fos mRNA levels in U-937 leukemia cells.	Tetradecanoylphorbol Acetate	77-80	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	102-107
1939341-2	1991	The present work demonstrates that the glucocorticoid dexamethasone inhibits TPA-induced increases in c-jun and c-fos mRNA levels in U-937 leukemia cells.	Tetradecanoylphorbol Acetate	77-80	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	112-117
1351055-3	1992	ICAM-1 mRNA is not detected in unstimulated human umbilical vein endothelial cells (HUVECs), but accumulates transiently following tumor necrosis factor-alpha (TNF-alpha) or phorbol myristate acetate (PMA) treatment with maximal steady state levels occurring at 2 or 4 h, respectively.	Tetradecanoylphorbol Acetate	174-199	intercellular adhesion molecule 1	Homo sapiens	0-6
1351055-3	1992	ICAM-1 mRNA is not detected in unstimulated human umbilical vein endothelial cells (HUVECs), but accumulates transiently following tumor necrosis factor-alpha (TNF-alpha) or phorbol myristate acetate (PMA) treatment with maximal steady state levels occurring at 2 or 4 h, respectively.	Tetradecanoylphorbol Acetate	201-204	intercellular adhesion molecule 1	Homo sapiens	0-6
1939341-4	1991	Other studies have demonstrated that TPA-induced monocytic differentiation and expression of the c-jun and c-fos genes in myeloid leukemia cells are regulated by protein kinase C (PKC).	Tetradecanoylphorbol Acetate	37-40	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	97-102
12194985-6	2002	Phorbol 12-myristate 13-acetate-induced PKC activation following forskolin treatment resulted in vesicular distribution of all AQP2 kinase mutants, while all were still phosphorylated at Ser-256.	Tetradecanoylphorbol Acetate	0-31	aquaporin 2	Canis lupus familiaris	127-131
1939341-4	1991	Other studies have demonstrated that TPA-induced monocytic differentiation and expression of the c-jun and c-fos genes in myeloid leukemia cells are regulated by protein kinase C (PKC).	Tetradecanoylphorbol Acetate	37-40	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-112
1939341-6	1991	Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.	Tetradecanoylphorbol Acetate	87-90	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-62
1939341-6	1991	Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.	Tetradecanoylphorbol Acetate	87-90	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	67-72
1939341-6	1991	Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.	Tetradecanoylphorbol Acetate	87-90	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	165-170
1939341-6	1991	Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.	Tetradecanoylphorbol Acetate	87-90	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	175-180
1939341-6	1991	Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.	Tetradecanoylphorbol Acetate	139-142	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-62
1351055-4	1992	Pretreating HUVECs with PMA for 72 h down-regulates protein kinase C and inhibits the subsequent induction of ICAM-1 mRNA by PMA, but does not affect TNF-alpha-induced message accumulation.	Tetradecanoylphorbol Acetate	24-27	intercellular adhesion molecule 1	Homo sapiens	110-116
1616941-8	1992	Short treatment with PMA decreased the activity of PKC 1 (peaks 1b (PKC-alpha) and 1c) and to a lesser extent of PKC 2; cells from lean animals were more sensitive to PMA than those obtained from obese rats.	Tetradecanoylphorbol Acetate	21-24	protein kinase C, alpha	Rattus norvegicus	68-77
1591723-9	1992	Treatment with 12-O-tetradecanoylphorbol-13-acetate for 90 min did not induce PLP mRNA transcripts, but 12-O-tetradecanoylphorbol-13-acetate blocked the rapid serum induction of PLP gene expression.	Tetradecanoylphorbol Acetate	104-140	parathyroid hormone-like hormone	Rattus norvegicus	178-181
12194985-7	2002	Our data indicate that in collecting duct cells, AQP2 trafficking to vasopressin-sensitive vesicles is phosphorylation-independent, that phosphorylation of Ser-256 is necessary and sufficient for expression of AQP2 in the apical membrane, and that PMA-induced PKC-mediated endocytosis of AQP2 is independent of the AQP2 phosphorylation state.	Tetradecanoylphorbol Acetate	248-251	aquaporin 2	Canis lupus familiaris	210-214
12194985-7	2002	Our data indicate that in collecting duct cells, AQP2 trafficking to vasopressin-sensitive vesicles is phosphorylation-independent, that phosphorylation of Ser-256 is necessary and sufficient for expression of AQP2 in the apical membrane, and that PMA-induced PKC-mediated endocytosis of AQP2 is independent of the AQP2 phosphorylation state.	Tetradecanoylphorbol Acetate	248-251	aquaporin 2	Canis lupus familiaris	210-214
1656230-4	1991	Within 5 min of TPA treatment, the alpha 1 protein became rapidly phosphorylated on serine residues and its expression was dramatically reduced by 24 h. The beta 2 protein, after an initial increase in expression, was also significantly reduced 24 h after treatment with TPA.	Tetradecanoylphorbol Acetate	16-19	hemoglobin, beta adult minor chain	Mus musculus	157-163
1656230-4	1991	Within 5 min of TPA treatment, the alpha 1 protein became rapidly phosphorylated on serine residues and its expression was dramatically reduced by 24 h. The beta 2 protein, after an initial increase in expression, was also significantly reduced 24 h after treatment with TPA.	Tetradecanoylphorbol Acetate	271-274	hemoglobin, beta adult minor chain	Mus musculus	157-163
12194985-7	2002	Our data indicate that in collecting duct cells, AQP2 trafficking to vasopressin-sensitive vesicles is phosphorylation-independent, that phosphorylation of Ser-256 is necessary and sufficient for expression of AQP2 in the apical membrane, and that PMA-induced PKC-mediated endocytosis of AQP2 is independent of the AQP2 phosphorylation state.	Tetradecanoylphorbol Acetate	248-251	aquaporin 2	Canis lupus familiaris	210-214
12149272-2	2002	Previous studies demonstrated an inhibition of LPL activity and synthesis following depletion of protein kinase C (PKC) isoforms with long term treatment of 3T3-F442A adipocytes with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	183-219	lipoprotein lipase	Homo sapiens	47-50
12151388-12	2002	Furthermore, K-Ras, the isoform previously shown to bind to calmodulin, is the only one activated by TPA when calmodulin is inhibited.	Tetradecanoylphorbol Acetate	101-104	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	13-18
12151388-14	2002	In vitro experiments showed that the phosphorylation of K-Ras by PKC was inhibited by calmodulin, suggesting that calmodulin-dependent modulation of K-Ras phosphorylation by PKC could be the mechanism underlying K-Ras activation in fibroblasts treated with TPA plus W13.	Tetradecanoylphorbol Acetate	257-260	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	56-61
12151388-14	2002	In vitro experiments showed that the phosphorylation of K-Ras by PKC was inhibited by calmodulin, suggesting that calmodulin-dependent modulation of K-Ras phosphorylation by PKC could be the mechanism underlying K-Ras activation in fibroblasts treated with TPA plus W13.	Tetradecanoylphorbol Acetate	257-260	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	149-154
12151388-14	2002	In vitro experiments showed that the phosphorylation of K-Ras by PKC was inhibited by calmodulin, suggesting that calmodulin-dependent modulation of K-Ras phosphorylation by PKC could be the mechanism underlying K-Ras activation in fibroblasts treated with TPA plus W13.	Tetradecanoylphorbol Acetate	257-260	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	149-154
12354938-1	2002	AIMS: To establish whether the MYB protein expressed in HL-60 variant cells, which are cells resistant to 12-O-tetradecanoylphorbol-13-acetate (TPA) induced differentiation, is able to bind MYB recognition elements (MREs) involved in the transcriptional regulation of myb target genes.	Tetradecanoylphorbol Acetate	144-147	MYB proto-oncogene, transcription factor	Homo sapiens	31-34
12270146-2	2002	We examined TPA-induced activation of the MEK1-ERK1/2 pathway in the 100,000g Triton X-insoluble fraction of CMK cells as the membrane skeleton and researched the relation of the MEK1-ERK1/2 activation with integrin expression.	Tetradecanoylphorbol Acetate	12-15	mitogen-activated protein kinase kinase 1	Homo sapiens	42-46
12270146-2	2002	We examined TPA-induced activation of the MEK1-ERK1/2 pathway in the 100,000g Triton X-insoluble fraction of CMK cells as the membrane skeleton and researched the relation of the MEK1-ERK1/2 activation with integrin expression.	Tetradecanoylphorbol Acetate	12-15	mitogen-activated protein kinase kinase 1	Homo sapiens	179-183
12186945-7	2002	Notably, sarcomeric myosin expression is induced by both TPA and UO126 but is abrogated by the p38 inhibitor.	Tetradecanoylphorbol Acetate	57-60	myosin heavy chain 14	Homo sapiens	20-26
12186945-9	2002	Anisomycin persistently activates p38 and JNKs but prevents myosin expression induced by TPA.	Tetradecanoylphorbol Acetate	89-92	myosin heavy chain 14	Homo sapiens	60-66
12167592-10	2002	The stimulatory effects of LDL on PAI-1, tPA, and uPA gene regulation in HMC were blocked by the inhibition of PKC using GF-109203X 12 h after treatment with LDL or downregulation of PKC using phorbol myristate acetate.	Tetradecanoylphorbol Acetate	193-218	serpin family E member 1	Homo sapiens	34-39
12213569-7	2002	Distinct from serum factors and the tumor promoter TPA-induced MAPKs, which resulted in transcriptional activation of ELK or c-JUN, TCDD-stimulated MAPKs were critical for the induction of AHR-dependent gene transcription and CYP1A1 expression.	Tetradecanoylphorbol Acetate	51-54	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	226-232
12271109-6	2002	Diurnal decreases in tPA and tPA-PAI ranged from 1.5 (VE) to 1.3 (controls), whereas the diurnal decrease in PAI-1 was more than fourfold in VE and 2.7-fold in controls.	Tetradecanoylphorbol Acetate	29-32	serpin family E member 1	Homo sapiens	33-36
12400610-6	2002	Evidence that RAFTK is a modulator of Akt came from phorbol myristic acetate (PMA) stimulation.	Tetradecanoylphorbol Acetate	78-81	protein tyrosine kinase 2 beta	Homo sapiens	14-19
12091710-6	2002	Total peripheral T cell numbers were significantly reduced in CnA beta(-/-) mice and were defective in proliferative capacity and IL-2 production in response to PMA/ionomycin and T cell receptor cross-linking.	Tetradecanoylphorbol Acetate	161-164	interleukin 2	Mus musculus	130-134
12110618-15	2002	Since TPA induced the translocation of PKC-epsilon but not of PKC-alpha in resting parietal cells, PKC-epsilon seems to be at least responsible for an initial elevation of free intracellular calcium to initiate TPA-induced acid secretion.	Tetradecanoylphorbol Acetate	6-9	protein kinase C epsilon	Homo sapiens	39-50
12110618-15	2002	Since TPA induced the translocation of PKC-epsilon but not of PKC-alpha in resting parietal cells, PKC-epsilon seems to be at least responsible for an initial elevation of free intracellular calcium to initiate TPA-induced acid secretion.	Tetradecanoylphorbol Acetate	211-214	protein kinase C epsilon	Homo sapiens	99-110
12429947-0	2002	UCN-01 (7-hydroxystauorsporine) blocks PMA-induced maturation and reciprocally promotes apoptosis in human myelomonocytic leukemia cells (U937).	Tetradecanoylphorbol Acetate	39-42	urocortin	Homo sapiens	0-3
12429947-3	2002	Instead, administration of UCN-01 with PMA led to a marked increase in mitochondrial injury (e.g, cytochrome c release), activation of caspases-3 and -8, Bid cleavage, PARP degradation, and apoptosis, accompanied by a substantial reduction in viability and clonogenic survival.	Tetradecanoylphorbol Acetate	39-42	urocortin	Homo sapiens	27-30
12061815-8	2002	SB/PMA treatment also triggered a decline in the S and G(2)M populations, and dephosphorylation of p34(cdc2).	Tetradecanoylphorbol Acetate	3-6	cyclin dependent kinase 1	Homo sapiens	103-107
11934885-5	2002	PKCepsilon activation was associated with increased focal adhesion and lamellipodia formation as well as clustering of select integrins, and it is required for phorbol 12-myristate 13-acetate-induced adhesion and motility.	Tetradecanoylphorbol Acetate	160-191	protein kinase C epsilon	Homo sapiens	0-10
11923289-2	2002	We show here that the oxidative stress-responsive transcription factor Bach2 is a generic inhibitor of gene expression directed by the 12-O-tetradecanoylphorbol-13-acetate response element, the Maf recognition element, and the antioxidant-responsive element.	Tetradecanoylphorbol Acetate	135-171	avian musculoaponeurotic fibrosarcoma oncogene homolog	Mus musculus	194-197
12028437-14	2002	In collagen gels, NRKproHB-EGF developed short tubule-like structures in the absence of TPA treatment, but with simultaneous TPA treatment, longer and more arborized structures developed.	Tetradecanoylphorbol Acetate	88-91	epidermal growth factor	Rattus norvegicus	27-30
12028437-14	2002	In collagen gels, NRKproHB-EGF developed short tubule-like structures in the absence of TPA treatment, but with simultaneous TPA treatment, longer and more arborized structures developed.	Tetradecanoylphorbol Acetate	125-128	epidermal growth factor	Rattus norvegicus	27-30
12028437-15	2002	MMP-1 mRNA and immunoreactive protein increased in the TPA-treated cells, suggesting that protein kinase C-mediated collagenase activity was important for the observed tubulogenesis.	Tetradecanoylphorbol Acetate	55-58	matrix metallopeptidase 1	Rattus norvegicus	0-5
12028437-16	2002	However, inhibition of EGF receptor tyrosine kinase with AG 1478 significantly blunted the TPA-induced tubulogenesis by NRKproHB-EGF grown in collagen gels.	Tetradecanoylphorbol Acetate	91-94	epidermal growth factor	Rattus norvegicus	23-26
12028437-16	2002	However, inhibition of EGF receptor tyrosine kinase with AG 1478 significantly blunted the TPA-induced tubulogenesis by NRKproHB-EGF grown in collagen gels.	Tetradecanoylphorbol Acetate	91-94	epidermal growth factor	Rattus norvegicus	129-132
12040026-6	2002	The second was identified as TIS11b (phorbol-12-myristate-13-acetate-inducible sequence 11b)/ERF-1/cMG, a member of the CCCH double-zinc finger protein family.	Tetradecanoylphorbol Acetate	37-68	eukaryotic translation termination factor 1	Bos taurus	93-98
12032821-10	2002	Moreover, p53 levels further increased in the mitochondria of DMBA/TPA treated mice, and this increase was much greater in the MnSOD KO than in the wild type mice, suggesting a link between MnSOD deficiency and mitochondrial-mediated apoptosis.	Tetradecanoylphorbol Acetate	67-70	transformation related protein 53, pseudogene	Mus musculus	10-13
11880362-7	2002	Second, treatment of U937 cells with TPA significantly increased (3-5-fold) hMSH2 expression and, to a lesser extent, hMSH6 and hPMS2 expression, correlated to a restoration of MMR function.	Tetradecanoylphorbol Acetate	37-40	mutS homolog 6	Homo sapiens	118-123
11880362-7	2002	Second, treatment of U937 cells with TPA significantly increased (3-5-fold) hMSH2 expression and, to a lesser extent, hMSH6 and hPMS2 expression, correlated to a restoration of MMR function.	Tetradecanoylphorbol Acetate	37-40	PMS1 homolog 2, mismatch repair system component	Homo sapiens	128-133
12222798-10	2002	Furthermore, addition of 1-(5-isoquinolinesylphonyl)-2-methlylpiperazine dihydrochloride (H-7), a potent PKC inhibitor, blocked the effect of PMA on total cell-associated u-PA activity.	Tetradecanoylphorbol Acetate	142-145	plasminogen activator, urokinase	Bos taurus	171-175
12222798-11	2002	Thus, PKC plays a role in the modulation of u-PA and u-PAR by PMA in bovine neutrophils.	Tetradecanoylphorbol Acetate	62-65	plasminogen activator, urokinase	Bos taurus	44-48
12081207-5	2002	The expression of immunoreactive MMP-8 protein was reduced 30% by transforming growth factor beta-1 (TGF-beta1) at 1 ng/ml concentration and 60% at 10 ng/ml concentration, but up-regulated 2- and 2.5-fold after 10 nM and 100 nM phorbol 12-myristate 13 acetate (PMA), respectively.	Tetradecanoylphorbol Acetate	228-259	matrix metallopeptidase 8	Homo sapiens	33-38
12081207-5	2002	The expression of immunoreactive MMP-8 protein was reduced 30% by transforming growth factor beta-1 (TGF-beta1) at 1 ng/ml concentration and 60% at 10 ng/ml concentration, but up-regulated 2- and 2.5-fold after 10 nM and 100 nM phorbol 12-myristate 13 acetate (PMA), respectively.	Tetradecanoylphorbol Acetate	261-264	matrix metallopeptidase 8	Homo sapiens	33-38
12069074-3	2002	When a human myelomonocytic cell line U937 was treated with phorbol 12-myristate 13-acetate for 3 days, the LPS-induced MAIL expression was much potentiated in parallel with an increase in TLR4 expression.	Tetradecanoylphorbol Acetate	60-91	toll like receptor 4	Homo sapiens	189-193
11882518-5	2002	After phorbol 12-myristate 13-acetate, TNFR1 shedding was significantly decreased in DM-2 compared with control subjects, and it was directly associated with insulin sensitivity (r = 0.54, P = 0.03).	Tetradecanoylphorbol Acetate	6-37	TNF receptor superfamily member 1A	Homo sapiens	39-44
1922053-1	1991	We have identified oncogene-responsive sequences in the human c-fos promoter that mediate induction of transcription by several nonnuclear oncoproteins and the tumor promoter TPA.	Tetradecanoylphorbol Acetate	175-178	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	62-67
11799119-5	2002	The TPA-stimulated phosphorylation of all these sites is sensitive to inhibitors of MEK and to the inhibitor of mTOR, rapamycin, indicating that inputs from both mTOR and MEK are required for the regulation of 4E-BP1 phosphorylation by TPA.	Tetradecanoylphorbol Acetate	4-7	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	210-216
1651842-10	1991	Lastly, the phorbol ester phorbol 12-myristate 13-acetate increased the level of the four protooncogene mRNAs, and its effects on c-fos and c-myc were significantly higher than those produced by hCG.	Tetradecanoylphorbol Acetate	26-57	protein c-Fos	Sus scrofa	130-135
1651842-10	1991	Lastly, the phorbol ester phorbol 12-myristate 13-acetate increased the level of the four protooncogene mRNAs, and its effects on c-fos and c-myc were significantly higher than those produced by hCG.	Tetradecanoylphorbol Acetate	26-57	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	140-145
11799119-5	2002	The TPA-stimulated phosphorylation of all these sites is sensitive to inhibitors of MEK and to the inhibitor of mTOR, rapamycin, indicating that inputs from both mTOR and MEK are required for the regulation of 4E-BP1 phosphorylation by TPA.	Tetradecanoylphorbol Acetate	236-239	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	210-216
12039071-3	2002	The phorbol ester, 1-O-tetradecanoyl phorbol-13-acetate (TPA; 12.5 nM) increased pERK levels, whereas protein kinase C (PKC) depletion or inhibition by GF109203X (GF; 0.01-10 microM) suppressed GnRH-activated ERKs.	Tetradecanoylphorbol Acetate	57-60	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	81-85
11874241-7	2002	TGF-beta increased FGF-2 mRNA expression within 2 h and this was sustained for 24 h. Phorbal myristate acetate (PMA; 1 microM) also increased FGF-2 mRNA at 6 h. Time course studies showed that TGF-beta did not significantly alter FGFR1 or FGFR2 mRNA expression in MG-63 cells.	Tetradecanoylphorbol Acetate	112-115	fibroblast growth factor receptor 2	Homo sapiens	239-244
1909627-1	1991	The differentiation into macrophages of the U937 and HL60 human cell lines induced by 4 beta-phorbol 12-myristate 13-acetate (PMA) was accompanied by induction of the expression of the proto-oncogenes c-jun, jun B and jun D. However, expression of the three jun genes was regulated differently during induction of cell differentiation in both U937 and HL60 cells, with the three jun family members being expressed distinctly at different stages of cell differentiation.	Tetradecanoylphorbol Acetate	86-124	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	201-206
1909627-1	1991	The differentiation into macrophages of the U937 and HL60 human cell lines induced by 4 beta-phorbol 12-myristate 13-acetate (PMA) was accompanied by induction of the expression of the proto-oncogenes c-jun, jun B and jun D. However, expression of the three jun genes was regulated differently during induction of cell differentiation in both U937 and HL60 cells, with the three jun family members being expressed distinctly at different stages of cell differentiation.	Tetradecanoylphorbol Acetate	126-129	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	201-206
11792635-6	2002	Eosinophils isolated from the lungs and stimulated with phorbol 12-myristate 13-acetate and/or A-23187 released IL-5.	Tetradecanoylphorbol Acetate	56-87	interleukin 5	Mus musculus	112-116
1659543-8	1991	However, tetradecanoyl-13-phorbol acetate (TPA, 200 nM) was able to induce c-fos mRNA expression.	Tetradecanoylphorbol Acetate	43-46	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	75-80
1659543-9	1991	The protein kinase C (PKC) inhibitors H-7 (0.3-30 microM) and staurosporine (0.75 micrograms/ml) blocked FSH-induced c-fos mRNA expression in cultured granulosa cells while HA 1004, an inhibitor of cGMP- and cAMP-dependent protein kinases at 30 microM had no effect on TPA-induced c-fos expression, and only minimally inhibited FSH-induced c-fos expression.	Tetradecanoylphorbol Acetate	269-272	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-122
11970838-8	2002	However, pretreatment with low concentrations of HOCl prevented phorbol myristate acetate-induced von Willebrand factor expression (a marker for P-selectin).	Tetradecanoylphorbol Acetate	64-89	selectin P	Homo sapiens	145-155
1800956-4	1991	The effect of gastrin was comparable to the stimulation induced by phorbol 12-myristate, 13-acetate (PMA), a strong activator of protein kinase C. The increase in protein synthesis induced by gastrin was totally abolished by 1-(5-isoquinolinyl)-2-methylpiperazine, an inhibitor of protein kinase C activity.	Tetradecanoylphorbol Acetate	101-104	gastrin	Rattus norvegicus	14-21
1573389-9	1992	CPE secretion is stimulated two- to threefold by prolonged treatment (3-48 h) with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) but not by treatment with other secretagogues that stimulate CPE secretion from AtT-20 cells (forskolin, isoproterenol, A23187, and vasoactive intestinal peptide) or short (less than 3 h) exposure to TPA.	Tetradecanoylphorbol Acetate	101-137	carboxypeptidase E	Mus musculus	0-3
1573389-9	1992	CPE secretion is stimulated two- to threefold by prolonged treatment (3-48 h) with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) but not by treatment with other secretagogues that stimulate CPE secretion from AtT-20 cells (forskolin, isoproterenol, A23187, and vasoactive intestinal peptide) or short (less than 3 h) exposure to TPA.	Tetradecanoylphorbol Acetate	139-142	carboxypeptidase E	Mus musculus	0-3
1573389-9	1992	CPE secretion is stimulated two- to threefold by prolonged treatment (3-48 h) with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) but not by treatment with other secretagogues that stimulate CPE secretion from AtT-20 cells (forskolin, isoproterenol, A23187, and vasoactive intestinal peptide) or short (less than 3 h) exposure to TPA.	Tetradecanoylphorbol Acetate	139-142	carboxypeptidase E	Mus musculus	205-208
1573389-9	1992	CPE secretion is stimulated two- to threefold by prolonged treatment (3-48 h) with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) but not by treatment with other secretagogues that stimulate CPE secretion from AtT-20 cells (forskolin, isoproterenol, A23187, and vasoactive intestinal peptide) or short (less than 3 h) exposure to TPA.	Tetradecanoylphorbol Acetate	344-347	carboxypeptidase E	Mus musculus	0-3
1800956-4	1991	The effect of gastrin was comparable to the stimulation induced by phorbol 12-myristate, 13-acetate (PMA), a strong activator of protein kinase C. The increase in protein synthesis induced by gastrin was totally abolished by 1-(5-isoquinolinyl)-2-methylpiperazine, an inhibitor of protein kinase C activity.	Tetradecanoylphorbol Acetate	101-104	gastrin	Rattus norvegicus	192-199
11729181-2	2002	Previous studies have demonstrated that phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, inhibits Fas (CD95)-mediated apoptosis in Jurkat (type II) cells but not SKW6.4 (type I) cells.	Tetradecanoylphorbol Acetate	40-71	Fas cell surface death receptor	Homo sapiens	123-127
1799373-1	1991	Murine T cell surface antigens, CD4 and CD8 are phosphorylated in response to phorbol 12-myristate 13-acetate, a protein kinase C activator, but not phosphorylated after concanavalin A, Ca2+ ionophore or dibutyryl-cAMP treatment.	Tetradecanoylphorbol Acetate	78-109	CD4 antigen	Mus musculus	32-35
1577756-5	1992	In the present study, the phorbol ester, phorbol 12-myristate 13-acetate (PMA), stimulated c-fos transcription in a rapid and dose-dependent manner with an 800% increase in transcription following 15-30 min of addition.	Tetradecanoylphorbol Acetate	41-72	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	91-96
1577756-5	1992	In the present study, the phorbol ester, phorbol 12-myristate 13-acetate (PMA), stimulated c-fos transcription in a rapid and dose-dependent manner with an 800% increase in transcription following 15-30 min of addition.	Tetradecanoylphorbol Acetate	74-77	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	91-96
1577756-7	1992	PMA stimulated the translocation of protein kinase C (PKC) from the cytoplasm to the membrane in H4 hepatoma cells, as evidenced by a 77% decrease in cytosolic PKC and a 29% increase in membrane PKC activity following 10 min of treatment.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, beta	Rattus norvegicus	54-57
11729181-2	2002	Previous studies have demonstrated that phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, inhibits Fas (CD95)-mediated apoptosis in Jurkat (type II) cells but not SKW6.4 (type I) cells.	Tetradecanoylphorbol Acetate	73-76	Fas cell surface death receptor	Homo sapiens	123-127
1577756-7	1992	PMA stimulated the translocation of protein kinase C (PKC) from the cytoplasm to the membrane in H4 hepatoma cells, as evidenced by a 77% decrease in cytosolic PKC and a 29% increase in membrane PKC activity following 10 min of treatment.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, beta	Rattus norvegicus	160-163
1577756-7	1992	PMA stimulated the translocation of protein kinase C (PKC) from the cytoplasm to the membrane in H4 hepatoma cells, as evidenced by a 77% decrease in cytosolic PKC and a 29% increase in membrane PKC activity following 10 min of treatment.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, beta	Rattus norvegicus	160-163
1577756-9	1992	When H4 cells were pretreated with PMA for 24 h, there was a decrease of 20-45% in both cytosolic and membrane PKC activity and a complete loss of PMA"s induction of c-fos transcription.	Tetradecanoylphorbol Acetate	35-38	protein kinase C, beta	Rattus norvegicus	111-114
1577756-9	1992	When H4 cells were pretreated with PMA for 24 h, there was a decrease of 20-45% in both cytosolic and membrane PKC activity and a complete loss of PMA"s induction of c-fos transcription.	Tetradecanoylphorbol Acetate	35-38	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	166-171
1577756-11	1992	When cells were pretreated with PMA for 24 h, the insulin-induced increase in transcription of c-fos was reduced by 50%.	Tetradecanoylphorbol Acetate	32-35	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	95-100
2054934-6	1991	ET-1, TPA, and ionomycin similarly induced the expression of c-fos after 30 minutes, which returned to an undetectable level after 6 hours.	Tetradecanoylphorbol Acetate	6-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	61-66
11923096-5	2002	Mutation of both these cysteines reduced the basal activity of rPLD2, however its response to PMA stimulation in vivo was retained.	Tetradecanoylphorbol Acetate	94-97	phospholipase D2	Rattus norvegicus	63-68
2055193-3	1991	In contrast, TPA induced an increase in mRNA for beta-actin.	Tetradecanoylphorbol Acetate	13-16	POTE ankyrin domain family member F	Homo sapiens	49-59
1510878-4	1992	PMA, which directly activates PKC, mimicked the effect of the lectins on c-Fos and c-Jun, but elevation of either intracellular Ca2+ or cAMP levels had little or no effect.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78
1510878-4	1992	PMA, which directly activates PKC, mimicked the effect of the lectins on c-Fos and c-Jun, but elevation of either intracellular Ca2+ or cAMP levels had little or no effect.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-88
11756662-3	2002	We report here that C/EBPbeta-nullizygous mice are completely refractory to skin tumor development induced by a variety of carcinogens and carcinogenesis protocols, including 7,12-dimethylbenz[a]anthracene-initiation/12-O-tetradecanoylphorbol 13-acetate promotion, that produce tumors containing oncogenic Ras mutations.	Tetradecanoylphorbol Acetate	217-253	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	20-29
1572102-0	1992	Relationship between a novel human cytotoxin (factor 2) produced by a B cell line (Karpas 160) and phorbol-myristate-acetate-associated cytotoxicity.	Tetradecanoylphorbol Acetate	99-124	transcription termination factor 2	Homo sapiens	46-54
1572102-3	1992	We were able to show that phorbol myristate acetate (PMA) greatly enhanced the production of F2, and PMA may also account for part of the putative F2 cytotoxic activity to K562 cells in crude preparations.	Tetradecanoylphorbol Acetate	26-51	transcription termination factor 2	Homo sapiens	93-95
1901945-1	1991	Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages.	Tetradecanoylphorbol Acetate	109-145	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	95-100
1901945-1	1991	Treatment of macrophages with interferon-gamma (IFN gamma) strongly decreased the induction of c-fos mRNA by 12-O-tetradecanoylphorbol-13-acetate (TPA), lipopolysaccharide, or calcium ionophore A23187 in macrophages.	Tetradecanoylphorbol Acetate	147-150	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	95-100
1901945-3	1991	Run-on experiments indicated that c-fos was constitutively transcribed at low levels and that TPA augmented c-fos transcription.	Tetradecanoylphorbol Acetate	94-97	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	108-113
1901945-6	1991	These results indicated that IFN gamma inhibited c-fos mRNA induction by TPA at the posttranscriptional level.	Tetradecanoylphorbol Acetate	73-76	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-54
1901948-7	1991	This preferential response of the c-jun gene is mediated by its 5" control region and requires the TPA response element, suggesting that this element also serves as an early target for the signal transduction pathway elicited by DNA damage.	Tetradecanoylphorbol Acetate	99-102	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-39
1572102-3	1992	We were able to show that phorbol myristate acetate (PMA) greatly enhanced the production of F2, and PMA may also account for part of the putative F2 cytotoxic activity to K562 cells in crude preparations.	Tetradecanoylphorbol Acetate	53-56	transcription termination factor 2	Homo sapiens	93-95
11928815-1	2002	The serine proteinase inhibitor plasminogen activator inhibitor type-1 (PAI-1) is the primary physiological inhibitor of the tissue-type and the urokinase-type plasminogen activator (tPA and uPA, respectively) and as such an important regulator of proteolytic events taking place in the circulation and in the extracellular matrix.	Tetradecanoylphorbol Acetate	183-186	serpin family E member 1	Homo sapiens	32-70
11928815-1	2002	The serine proteinase inhibitor plasminogen activator inhibitor type-1 (PAI-1) is the primary physiological inhibitor of the tissue-type and the urokinase-type plasminogen activator (tPA and uPA, respectively) and as such an important regulator of proteolytic events taking place in the circulation and in the extracellular matrix.	Tetradecanoylphorbol Acetate	183-186	serpin family E member 1	Homo sapiens	72-77
1563479-0	1992	Cell cycle-dependent vimentin expression in elutriator-synchronized, TPA-treated MPC-11 mouse plasmacytoma cells.	Tetradecanoylphorbol Acetate	69-72	vimentin	Mus musculus	21-29
1909909-1	1991	The mutation was revealed with substitution of A for T in the second position of the 61 Ha-ras oncogene codon in the DNA of 31 skin tumours (26 papillomas and 5 carcinomas) and in 23 mice treated with 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	201-238	Harvey rat sarcoma virus oncogene	Mus musculus	88-94
12421622-6	2002	Cortical cultures treated with glutamate, forskolin or the phorbol ester phorbol 12-myristate 13-acetate exhibited robust increases in phospho-CREB.	Tetradecanoylphorbol Acetate	73-104	cAMP responsive element binding protein 1	Rattus norvegicus	143-147
2004606-0	1991	The effects of phorbol myristate acetate on the intracellular degradation of bovine parathyroid hormone.	Tetradecanoylphorbol Acetate	15-40	parathyroid hormone	Bos taurus	84-103
2004606-2	1991	In the presence of high extracellular Ca2+, phorbol myristate acetate (PMA) has been shown to stimulate PTH release to levels observed at low Ca2+, suggesting that protein kinase-C (PKC) is involved in the regulation of PTH secretion.	Tetradecanoylphorbol Acetate	44-69	parathyroid hormone	Bos taurus	104-107
2004606-2	1991	In the presence of high extracellular Ca2+, phorbol myristate acetate (PMA) has been shown to stimulate PTH release to levels observed at low Ca2+, suggesting that protein kinase-C (PKC) is involved in the regulation of PTH secretion.	Tetradecanoylphorbol Acetate	44-69	parathyroid hormone	Bos taurus	220-223
1563479-3	1992	A 6-h TPA treatment of G1-phase-enriched cultures induced both a partial G1-phase arrest in the same cycle and a moderate fraction of cells to become vimentin positive.	Tetradecanoylphorbol Acetate	6-9	vimentin	Mus musculus	150-158
1563479-4	1992	However, nearly all cells of the cultures enriched in S- or in G2/M-phase cells could be arrested by TPA treatment at the earliest in the G1 phase of the second cell cycle and displayed higher fractions of positive cells as well as higher average levels of vimentin.	Tetradecanoylphorbol Acetate	101-104	vimentin	Mus musculus	257-265
1563479-6	1992	In terms of fractions of vimentin-positive cells as well as of average cellular vimentin content, the differences between the cultures resembled, albeit on a higher level, those between the respective cultures treated with TPA for 6 h. These observations might explain the striking bimodal distribution of individual cellular vimentin content detectable in G1-phase fractions of asynchronous, TPA-treated cultures.	Tetradecanoylphorbol Acetate	223-226	vimentin	Mus musculus	25-33
1563479-6	1992	In terms of fractions of vimentin-positive cells as well as of average cellular vimentin content, the differences between the cultures resembled, albeit on a higher level, those between the respective cultures treated with TPA for 6 h. These observations might explain the striking bimodal distribution of individual cellular vimentin content detectable in G1-phase fractions of asynchronous, TPA-treated cultures.	Tetradecanoylphorbol Acetate	223-226	vimentin	Mus musculus	80-88
1563479-6	1992	In terms of fractions of vimentin-positive cells as well as of average cellular vimentin content, the differences between the cultures resembled, albeit on a higher level, those between the respective cultures treated with TPA for 6 h. These observations might explain the striking bimodal distribution of individual cellular vimentin content detectable in G1-phase fractions of asynchronous, TPA-treated cultures.	Tetradecanoylphorbol Acetate	223-226	vimentin	Mus musculus	80-88
1566818-2	1992	The B lymphoblastoid line JY expresses both LFA-1 and ICAM-1, and intercellular adhesion is enhanced by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which also induced capping of LFA-1, ICAM-1, and human leukocyte antigen.	Tetradecanoylphorbol Acetate	137-168	intercellular adhesion molecule 1	Homo sapiens	54-60
1566818-2	1992	The B lymphoblastoid line JY expresses both LFA-1 and ICAM-1, and intercellular adhesion is enhanced by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which also induced capping of LFA-1, ICAM-1, and human leukocyte antigen.	Tetradecanoylphorbol Acetate	137-168	intercellular adhesion molecule 1	Homo sapiens	213-219
1566818-2	1992	The B lymphoblastoid line JY expresses both LFA-1 and ICAM-1, and intercellular adhesion is enhanced by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which also induced capping of LFA-1, ICAM-1, and human leukocyte antigen.	Tetradecanoylphorbol Acetate	170-173	intercellular adhesion molecule 1	Homo sapiens	213-219
2004606-2	1991	In the presence of high extracellular Ca2+, phorbol myristate acetate (PMA) has been shown to stimulate PTH release to levels observed at low Ca2+, suggesting that protein kinase-C (PKC) is involved in the regulation of PTH secretion.	Tetradecanoylphorbol Acetate	71-74	parathyroid hormone	Bos taurus	104-107
2004606-2	1991	In the presence of high extracellular Ca2+, phorbol myristate acetate (PMA) has been shown to stimulate PTH release to levels observed at low Ca2+, suggesting that protein kinase-C (PKC) is involved in the regulation of PTH secretion.	Tetradecanoylphorbol Acetate	71-74	parathyroid hormone	Bos taurus	220-223
11728381-0	2001	Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated CYP1A1 and CYP1B1 induction by 12-O-tetradecanoylphorbol-13-acetate: role of transforming growth factor beta and mitogen-activated protein kinases.	Tetradecanoylphorbol Acetate	98-134	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	67-73
11728381-1	2001	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances or suppresses the transcriptional activation of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a cell/tissue-specific manner.	Tetradecanoylphorbol Acetate	18-54	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	118-124
1656239-4	1991	Potent phorbol esters, such as phorbol myristate acetate (PMA) and phorbol-12,13-dibutyrate, whose biological actions have been shown to be mediated through the activation of protein kinase-C, down-regulated VDR in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	31-56	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	208-211
11728381-1	2001	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances or suppresses the transcriptional activation of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a cell/tissue-specific manner.	Tetradecanoylphorbol Acetate	56-59	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	118-124
1656239-4	1991	Potent phorbol esters, such as phorbol myristate acetate (PMA) and phorbol-12,13-dibutyrate, whose biological actions have been shown to be mediated through the activation of protein kinase-C, down-regulated VDR in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	58-61	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	208-211
11728381-3	2001	Exposure of the immortalized human breast epithelial cell line MCF10A-Neo to TPA at the time of, or up to 12 hr prior to, the addition of TCDD strongly suppressed the transcriptional activation of CYP1A1 and CYP1B1 (IC(50) approximately 0.5 nM).	Tetradecanoylphorbol Acetate	77-80	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	197-203
1656239-6	1991	Desensitization of protein kinase-C by prolonged exposure of cells to phorbol esters eliminated the PMA-mediated down-regulation of VDR.	Tetradecanoylphorbol Acetate	100-103	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	132-135
11728381-5	2001	The suppressive effects of TPA on CYP1A1 induction by TCDD in MCF10A-Neo cultures could be partially suppressed by: (a) co-incubation of TCDD + TPA-treated cultures with a neutralizing TGFbeta pan antibody; (b) prior removal of latent TGFbeta from the culture medium; or (c) switching cultures to serum- and growth factor-free medium immediately before the addition of TPA and TCDD.	Tetradecanoylphorbol Acetate	27-30	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	34-40
2005087-7	1991	In keeping with this view, bFGF, and to a lesser degree NGF, can elicit a TIS gene response in PC12 cells in which PK-C has been down-regulated with TPA.	Tetradecanoylphorbol Acetate	149-152	protein kinase C, gamma	Rattus norvegicus	115-119
11728381-5	2001	The suppressive effects of TPA on CYP1A1 induction by TCDD in MCF10A-Neo cultures could be partially suppressed by: (a) co-incubation of TCDD + TPA-treated cultures with a neutralizing TGFbeta pan antibody; (b) prior removal of latent TGFbeta from the culture medium; or (c) switching cultures to serum- and growth factor-free medium immediately before the addition of TPA and TCDD.	Tetradecanoylphorbol Acetate	144-147	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	34-40
11728381-5	2001	The suppressive effects of TPA on CYP1A1 induction by TCDD in MCF10A-Neo cultures could be partially suppressed by: (a) co-incubation of TCDD + TPA-treated cultures with a neutralizing TGFbeta pan antibody; (b) prior removal of latent TGFbeta from the culture medium; or (c) switching cultures to serum- and growth factor-free medium immediately before the addition of TPA and TCDD.	Tetradecanoylphorbol Acetate	144-147	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	34-40
11728381-6	2001	Exposure of cultures to TPA 24-48 hr prior to subsequent TPA + TCDD treatment not only inhibited the suppressive effects of TPA, but markedly enhanced CYP1A1 mRNA accumulation.	Tetradecanoylphorbol Acetate	24-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	151-157
11753654-5	2001	We demonstrate that tumor promotion by TPA (12-O-tetradecanoylphorbol-13-acetate) also induces expression of BMP-6 in suprabasal keratinocytes.	Tetradecanoylphorbol Acetate	39-42	bone morphogenetic protein 6	Mus musculus	109-114
2002015-1	1991	Eukaryotic initiation factor (eIF) 4F, a multiprotein cap binding complex, has been shown to be phosphorylated in vivo in response to phorbol 12-myristate 13-acetate and insulin (Morley, S.J., and Traugh, J.A.	Tetradecanoylphorbol Acetate	134-165	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	0-37
1900458-2	1991	AP-1 consists of the products of the fos and jun oncogenes, which associate as dimers to bind TPA-responsive promoter elements (TRE) efficiently.	Tetradecanoylphorbol Acetate	94-97	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-40
11753654-5	2001	We demonstrate that tumor promotion by TPA (12-O-tetradecanoylphorbol-13-acetate) also induces expression of BMP-6 in suprabasal keratinocytes.	Tetradecanoylphorbol Acetate	44-80	bone morphogenetic protein 6	Mus musculus	109-114
11753654-11	2001	A higher rate of apoptotic keratinocytes was detectable in transgenic mice versus controls and a downregulation of mRNA for jun/fos family members in transgenic skin after TPA-treatment.	Tetradecanoylphorbol Acetate	172-175	FBJ osteosarcoma oncogene	Mus musculus	128-131
11707282-4	2001	On the other hand, PKCbeta inhibition suppressed the TPA-stimulated increase in neuropeptide Y mRNA, activation of neuropeptide Y gene promoter elements, and phosphorylation of Erk1/2.	Tetradecanoylphorbol Acetate	53-56	neuropeptide Y	Homo sapiens	80-94
1849053-3	1991	In this study, we demonstrate by stereochemical analysis of tetraol products that primarily anti-diolepoxides are being formed from (+-)-B[a]P-7,8-diol by TPA-stimulated PMNs with an anti/syn ratio of 6.	Tetradecanoylphorbol Acetate	155-158	synemin	Homo sapiens	188-191
11707282-4	2001	On the other hand, PKCbeta inhibition suppressed the TPA-stimulated increase in neuropeptide Y mRNA, activation of neuropeptide Y gene promoter elements, and phosphorylation of Erk1/2.	Tetradecanoylphorbol Acetate	53-56	neuropeptide Y	Homo sapiens	115-129
11707282-5	2001	The TPA-induced increase in neuropeptide Y expression was also inhibited by the MEK inhibitor PD98059.	Tetradecanoylphorbol Acetate	4-7	neuropeptide Y	Homo sapiens	28-42
11696370-2	2001	We observed (i) NAD-dependent enzyme activity and mRNA for 11beta-HSD2, but not 11beta-HSD1, (ii) increasing 11beta-HSD2 activity with increasing degree of differentiation and (iii) a concentration-dependent down-regulation by TNF-alpha, phorbol myristate acetate (PMA) or glucose of activity and mRNA of 11beta-HSD2.	Tetradecanoylphorbol Acetate	238-263	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	59-70
1832138-1	1991	In the present study the effect of 72-5D3 monoclonal antibody (CD45) on the proliferation induced by cross-linking of surface immunoglobulins on untreated and 4 beta-phorbol 12-myristate 13-acetate-treated human dense B cells was studied.	Tetradecanoylphorbol Acetate	161-197	protein tyrosine phosphatase receptor type C	Homo sapiens	63-67
11696370-2	2001	We observed (i) NAD-dependent enzyme activity and mRNA for 11beta-HSD2, but not 11beta-HSD1, (ii) increasing 11beta-HSD2 activity with increasing degree of differentiation and (iii) a concentration-dependent down-regulation by TNF-alpha, phorbol myristate acetate (PMA) or glucose of activity and mRNA of 11beta-HSD2.	Tetradecanoylphorbol Acetate	238-263	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	109-120
11696370-2	2001	We observed (i) NAD-dependent enzyme activity and mRNA for 11beta-HSD2, but not 11beta-HSD1, (ii) increasing 11beta-HSD2 activity with increasing degree of differentiation and (iii) a concentration-dependent down-regulation by TNF-alpha, phorbol myristate acetate (PMA) or glucose of activity and mRNA of 11beta-HSD2.	Tetradecanoylphorbol Acetate	238-263	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	109-120
11911279-7	2001	In contrast, we showed a slight increase of vimentin content in phorbol ester (PMA)-treated NB4 cells.	Tetradecanoylphorbol Acetate	79-82	vimentin	Homo sapiens	44-52
1825219-3	1991	We have examined the cell surface expression of alpha 5, alpha 4, and beta 1 subunits on purified peripheral blood T lymphocytes before and after activation with Con A and PMA.	Tetradecanoylphorbol Acetate	172-175	immunoglobulin binding protein 1	Homo sapiens	48-76
1825219-8	1991	After 72-h culture with Con A and PMA, a wide distribution of alpha 4 expression was observed.	Tetradecanoylphorbol Acetate	34-37	immunoglobulin binding protein 1	Homo sapiens	62-69
1847463-8	1991	Induction of c-fos by serum or 12-O-tetradecanoylphorbol-13-acetate is independent of temperature.	Tetradecanoylphorbol Acetate	31-67	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-18
11687282-4	2001	Treatment of the cells with TPA caused decreases in AQP4 and 9 mRNAs and proteins in time- and concentration-dependent manners.	Tetradecanoylphorbol Acetate	28-31	aquaporin 4	Rattus norvegicus	52-56
1653896-6	1991	Three lines of evidence suggest that protein kinase-C (PKC) mediates serum-stimulated PES gene expression: 1) 12-tetradecanoyl phorbol 13-acetate mimicked the serum response; 2) PES gene expression by serum was attenuated in cells depleted of PKC; and 3) a PKC inhibitor, sangivamycin, blocked serum-stimulated PES gene induction.	Tetradecanoylphorbol Acetate	110-145	protein kinase C, gamma	Rattus norvegicus	37-53
1653896-6	1991	Three lines of evidence suggest that protein kinase-C (PKC) mediates serum-stimulated PES gene expression: 1) 12-tetradecanoyl phorbol 13-acetate mimicked the serum response; 2) PES gene expression by serum was attenuated in cells depleted of PKC; and 3) a PKC inhibitor, sangivamycin, blocked serum-stimulated PES gene induction.	Tetradecanoylphorbol Acetate	110-145	protein kinase C, gamma	Rattus norvegicus	55-58
11687282-5	2001	The TPA-induced decreases in AQP4 and 9 mRNAs were inhibited by PKC inhibitors.	Tetradecanoylphorbol Acetate	4-7	aquaporin 4	Rattus norvegicus	29-33
11687282-6	2001	Moreover, prolonged treatment of the cells with TPA eliminated the subsequent decreases in AQP4 and 9 mRNAs caused by TPA.	Tetradecanoylphorbol Acetate	48-51	aquaporin 4	Rattus norvegicus	91-95
11687282-6	2001	Moreover, prolonged treatment of the cells with TPA eliminated the subsequent decreases in AQP4 and 9 mRNAs caused by TPA.	Tetradecanoylphorbol Acetate	118-121	aquaporin 4	Rattus norvegicus	91-95
1996120-1	1991	The TIS11 primary response gene is rapidly and transiently induced by both 12-O-tetradecanoylphorbol-13-acetate and growth factors.	Tetradecanoylphorbol Acetate	75-111	zinc finger protein 36	Rattus norvegicus	4-9
11605028-7	2001	In Western blotting, matrix metalloproteinase (MMP)-1 (tissue collagenase) but not MMP-2 (72-kDa gelatinase) expression was upregulated by PDGF and phorbol ester (TPA), which were reduced by diltiazem in a dose-dependent manner.	Tetradecanoylphorbol Acetate	163-166	matrix metallopeptidase 1	Homo sapiens	21-53
2011401-3	1991	In unstimulated proliferating JURKAT cells, high levels of C-MYC, N-RAS, and BCL2 mRNAs were found that diminished rapidly following TPA-induced cessation of growth.	Tetradecanoylphorbol Acetate	133-136	NRAS proto-oncogene, GTPase	Homo sapiens	66-71
2011401-4	1991	In contrast, accumulation of mRNAs for the C-FOS, C-JUN, and EGR-1 genes increased markedly in TPA-treated cells and preceded the induction of IL2R-alpha mRNA.	Tetradecanoylphorbol Acetate	95-98	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-55
11605028-7	2001	In Western blotting, matrix metalloproteinase (MMP)-1 (tissue collagenase) but not MMP-2 (72-kDa gelatinase) expression was upregulated by PDGF and phorbol ester (TPA), which were reduced by diltiazem in a dose-dependent manner.	Tetradecanoylphorbol Acetate	163-166	matrix metallopeptidase 1	Homo sapiens	55-73
11642552-10	2001	In contrast, high dose of TPA inhibited hTERT expression level.	Tetradecanoylphorbol Acetate	26-29	telomerase reverse transcriptase	Homo sapiens	40-45
11478838-4	2001	Following TPA treatment: lamins A/C and B1, B2 and vimentin increased in amount; LAP2 beta and emerin remained essentially unchanged; LBR increased markedly; histone subtypes H1.4 and 1.5 exhibited dephosphorylation.	Tetradecanoylphorbol Acetate	10-13	membrane spanning 4-domains A1	Homo sapiens	34-46
11478838-4	2001	Following TPA treatment: lamins A/C and B1, B2 and vimentin increased in amount; LAP2 beta and emerin remained essentially unchanged; LBR increased markedly; histone subtypes H1.4 and 1.5 exhibited dephosphorylation.	Tetradecanoylphorbol Acetate	10-13	vimentin	Homo sapiens	51-59
11478838-5	2001	Emerin, which was cytoplasmic in undifferentiated or granulocytic cells, localized into the nuclear envelope following TPA.	Tetradecanoylphorbol Acetate	119-122	emerin	Homo sapiens	0-6
11402047-6	2001	12-O-Tetradecanoylphorbol-13-acetate is another potent inducer of pro HB-EGF shedding.	Tetradecanoylphorbol Acetate	0-36	heparin binding EGF like growth factor	Homo sapiens	70-76
11402047-7	2001	We also demonstrate that the LPA-induced pathway is distinct from the 12-O-tetradecanoylphorbol-13-acetate-induced pathway and that these pathways constitute a dual signaling cascade that regulates the shedding of pro HB-EGF.	Tetradecanoylphorbol Acetate	70-106	heparin binding EGF like growth factor	Homo sapiens	218-224
11446769-5	2001	Protein kinase C (PKC) activator TPA also induced the phosphorylation of p70 S6K.	Tetradecanoylphorbol Acetate	33-36	ribosomal protein S6 kinase B1	Homo sapiens	73-80
1547736-2	1992	Phorbol 12-myristate 13-acetate (PMA), an activator of PKC, inhibited the stimulation of aldosterone production induced by K+ (5.4 mM) or ACTH (5 pM) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, gamma	Rattus norvegicus	55-58
1547736-2	1992	Phorbol 12-myristate 13-acetate (PMA), an activator of PKC, inhibited the stimulation of aldosterone production induced by K+ (5.4 mM) or ACTH (5 pM) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, gamma	Rattus norvegicus	55-58
1547736-4	1992	The inhibitory effect of PMA (5 nM) was reversed by preincubation of the cells with staurosporine (ST; 50 nM), an inhibitor of PKC.	Tetradecanoylphorbol Acetate	25-28	protein kinase C, gamma	Rattus norvegicus	127-130
11424083-8	2001	The PLC inhibitors, neomycin and U73,122, and PKC-alpha down regulator, phorbol 12-myristate 13-acetate (PMA), were able to prevent estradiol-induced DNA synthesis in hepatoma cells, but ineffective in mammary cells; wortmannin, an inhibitor of phosphoinositide 3-kinases (PI3-K), blocked DNA synthesis in both cell lines.	Tetradecanoylphorbol Acetate	72-103	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	245-271
11424083-8	2001	The PLC inhibitors, neomycin and U73,122, and PKC-alpha down regulator, phorbol 12-myristate 13-acetate (PMA), were able to prevent estradiol-induced DNA synthesis in hepatoma cells, but ineffective in mammary cells; wortmannin, an inhibitor of phosphoinositide 3-kinases (PI3-K), blocked DNA synthesis in both cell lines.	Tetradecanoylphorbol Acetate	105-108	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	245-271
11467851-6	2001	Expression of the PKCepsilon inhibitor inhibited PMA-induced APPs secretion and suppression of Abeta production.	Tetradecanoylphorbol Acetate	49-52	protein kinase C epsilon	Homo sapiens	18-28
11320078-3	2001	In this report, we show that binding to the HIV-2 pets site is modulated by treatment of U937 monocytic cells with TPA, an activator of protein kinase C. TPA treatment resulted in a reduction in the levels of DEK and the formation of a faster migrating pets complex in gel shift assays.	Tetradecanoylphorbol Acetate	115-118	DEK proto-oncogene	Homo sapiens	209-212
11320078-3	2001	In this report, we show that binding to the HIV-2 pets site is modulated by treatment of U937 monocytic cells with TPA, an activator of protein kinase C. TPA treatment resulted in a reduction in the levels of DEK and the formation of a faster migrating pets complex in gel shift assays.	Tetradecanoylphorbol Acetate	154-157	DEK proto-oncogene	Homo sapiens	209-212
11320078-4	2001	We show further that the actions of TPA on pets binding can be duplicated by phosphatase treatment of nuclear proteins and is blocked with okadaic acid, a protein phospatase-2A (PP2A) inhibitor.	Tetradecanoylphorbol Acetate	36-39	protein phosphatase 2 phosphatase activator	Homo sapiens	163-176
11320078-4	2001	We show further that the actions of TPA on pets binding can be duplicated by phosphatase treatment of nuclear proteins and is blocked with okadaic acid, a protein phospatase-2A (PP2A) inhibitor.	Tetradecanoylphorbol Acetate	36-39	protein phosphatase 2 phosphatase activator	Homo sapiens	178-182
11320078-5	2001	Finally, we demonstrate that ectopic expression of the catalytic domain of PP2A can activate the HIV-2 enhancer/promoter alone or in synergy with TPA, an effect mediated in part through the pets site.	Tetradecanoylphorbol Acetate	146-149	protein phosphatase 2 phosphatase activator	Homo sapiens	75-79
11404234-4	2001	Treatment with phorbol ester [12-O-tetradecanoyl-phorbol-13-acetate (TPA) 100 nM], an activator of protein kinase C, significantly enhanced 1,25(OH)2D3-induced OPN mRNA and transcription but had no effect on VDR or on 24(OH)ase mRNA or transcription.	Tetradecanoylphorbol Acetate	69-72	vitamin D receptor	Rattus norvegicus	208-211
11404234-5	2001	Studies using OPN promoter constructs indicate that TPA-enhanced OPN transcription is mediated by an effect on the OPN promoter separate from an effect on VDR.	Tetradecanoylphorbol Acetate	52-55	vitamin D receptor	Rattus norvegicus	155-158
11283017-9	2001	3) The beta3Gn-T5 expression was up-regulated by stimulation with retinoic acid and down-regulated with 12-O-tetradecanoylphorbol-13-acetate in HL-60 cells.	Tetradecanoylphorbol Acetate	104-140	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	Homo sapiens	7-17
11283014-4	2001	A WASP mutant with a deletion in the C-terminal region (WASPDeltaC) that is defective in actin polymerization potentiated NFAT transcription following TCR activation by anti-CD3 and anti-CD3/CD28 antibodies, but not by phorbol 12-myristate 13-acetate/ionomycin.	Tetradecanoylphorbol Acetate	219-250	WASP actin nucleation promoting factor	Homo sapiens	2-6
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	87-90	lysine demethylase and nuclear receptor corepressor	Mus musculus	269-271
11398145-12	2001	PAI-1 together with trigylcerides (both P &lt;.0001) and age (P &lt;.04) were main determinants for tPA-Ag (adj, R(2) =.41).	Tetradecanoylphorbol Acetate	100-103	serpin family E member 1	Homo sapiens	0-5
11311131-5	2001	Furthermore, PMA-induced Hic-5 tyrosine phosphorylation was also observed when platelets adhered to immobilized fibrinogen.	Tetradecanoylphorbol Acetate	13-16	transforming growth factor beta 1 induced transcript 1	Homo sapiens	25-30
11446745-2	2001	IL-1beta up-regulation is not dependent on PKC but the PKC activator PMA induces low levels of GM-CSF production and acts synergistically with IL-1beta to further increase GM-CSF.	Tetradecanoylphorbol Acetate	69-72	colony stimulating factor 2	Homo sapiens	95-101
11446745-2	2001	IL-1beta up-regulation is not dependent on PKC but the PKC activator PMA induces low levels of GM-CSF production and acts synergistically with IL-1beta to further increase GM-CSF.	Tetradecanoylphorbol Acetate	69-72	colony stimulating factor 2	Homo sapiens	172-178
11278385-0	2001	Extracellular signal-regulated kinase/90-KDA ribosomal S6 kinase/nuclear factor-kappa B pathway mediates phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells.	Tetradecanoylphorbol Acetate	105-136	ribosomal protein S6 kinase A1	Homo sapiens	45-64
11278385-6	2001	PMA-stimulated activation of ERK/MAPK, RSK1, and NF-kappaB and the PMA-induced megakaryocytic differentiation were prevented by pretreatment with PD98059, a specific inhibitor of the mitogen-activated ERK kinase (MEK).	Tetradecanoylphorbol Acetate	0-3	ribosomal protein S6 kinase A1	Homo sapiens	39-43
11277940-4	2001	The reduction in guanylate cyclase C mRNA was inhibited when cells were treated with 4beta-phorbol 12-myristate 13-acetate (PMA) in the presence of staurosporine, indicating that a primary phosphorylation event by protein kinase C triggered the reduction in RNA levels.	Tetradecanoylphorbol Acetate	85-122	natriuretic peptide receptor 3	Homo sapiens	17-36
11277940-4	2001	The reduction in guanylate cyclase C mRNA was inhibited when cells were treated with 4beta-phorbol 12-myristate 13-acetate (PMA) in the presence of staurosporine, indicating that a primary phosphorylation event by protein kinase C triggered the reduction in RNA levels.	Tetradecanoylphorbol Acetate	124-127	natriuretic peptide receptor 3	Homo sapiens	17-36
11341521-0	2001	The expression of exercise-induced tPA activity in blood is regulated by the basal level of PAI-1.	Tetradecanoylphorbol Acetate	35-38	serpin family E member 1	Homo sapiens	92-97
11297424-4	2001	RGS4, but not DeltaRGS4, also blocked phosphorylation of PAFR by platelet-activating factor (PAF) and, unexpectedly, by phorbol 12-myristate 13-acetate (PMA); it also blocked cross-phosphorylation by formylmethionylleucylphenylalanine (fMLP).	Tetradecanoylphorbol Acetate	120-151	regulator of G-protein signaling 4	Rattus norvegicus	0-4
11297424-4	2001	RGS4, but not DeltaRGS4, also blocked phosphorylation of PAFR by platelet-activating factor (PAF) and, unexpectedly, by phorbol 12-myristate 13-acetate (PMA); it also blocked cross-phosphorylation by formylmethionylleucylphenylalanine (fMLP).	Tetradecanoylphorbol Acetate	153-156	regulator of G-protein signaling 4	Rattus norvegicus	0-4
1991168-5	1991	Monocytes exposed to inactivated streptococci, phorbol-12-myristate-13-acetate, and tumor necrosis factor showed augmented levels of hsp70 transcripts, whereas interferon-gamma and monocyte, granulocyte, and granulocyte-monocyte colony-stimulating factors had no effect.	Tetradecanoylphorbol Acetate	47-78	heat shock protein family A (Hsp70) member 4	Homo sapiens	133-138
11313860-5	2001	Furthermore, thymocytes and splenic T cells from lck-Mad1 transgenic mice display a profound proliferative defect in response to activation with either PMA/Ionomycin or immobilized anti-CD3/CD28 antibody.	Tetradecanoylphorbol Acetate	152-155	MAX dimerization protein 1	Mus musculus	53-57
11298136-9	2001	The results obtained during a three year period in the proliferation assays show an impaired PMA (phorbol myristate acetate) activation in specific T lymphocyte activation pathways (CD69, CD26, CD28, CD3, PHA, PWM and Con A mediated) but not in others (CD2, ionomycin, and Ig surface receptor).	Tetradecanoylphorbol Acetate	98-123	dipeptidyl peptidase 4	Homo sapiens	188-192
11298136-9	2001	The results obtained during a three year period in the proliferation assays show an impaired PMA (phorbol myristate acetate) activation in specific T lymphocyte activation pathways (CD69, CD26, CD28, CD3, PHA, PWM and Con A mediated) but not in others (CD2, ionomycin, and Ig surface receptor).	Tetradecanoylphorbol Acetate	98-123	CD2 molecule	Homo sapiens	188-191
11260269-5	2001	Treatment of quiescent NIH-3T3 cells with FGF, PDGF or TPA, which induced the sustained activation of ERKs, resulted in the strong induction of SGK, whereas treatment with EGF, which induced the transient activation of ERKs, did not induce a strong expression of SGK.	Tetradecanoylphorbol Acetate	55-58	serum/glucocorticoid regulated kinase 1	Mus musculus	144-147
1899810-1	1991	A topical application of a chalcone derivative, 4,2",4"-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice.	Tetradecanoylphorbol Acetate	234-270	ornithine decarboxylase, structural 1	Mus musculus	140-143
1899810-1	1991	A topical application of a chalcone derivative, 4,2",4"-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice.	Tetradecanoylphorbol Acetate	272-275	ornithine decarboxylase, structural 1	Mus musculus	140-143
11260269-5	2001	Treatment of quiescent NIH-3T3 cells with FGF, PDGF or TPA, which induced the sustained activation of ERKs, resulted in the strong induction of SGK, whereas treatment with EGF, which induced the transient activation of ERKs, did not induce a strong expression of SGK.	Tetradecanoylphorbol Acetate	55-58	serum/glucocorticoid regulated kinase 1	Mus musculus	263-266
11287749-4	2001	Our findings suggest that TPA-induced tyrosine phosphorylation of FAK and paxillin in human hepatoma cells is PKC dependent and requires the integrity of the cell cytoskeleton but is uncoupled to the signal transduction pathway of PKC leading to the translocation of PKC and MAPK activation.	Tetradecanoylphorbol Acetate	26-29	paxillin	Homo sapiens	74-82
1988296-2	1991	In this study, we have examined expression of mRNA for these proteins, including the major 70-kDa heat shock protein, HSP70, in mononuclear cells following either heat shock or mitogenic activation with phytohemagglutinin (PHA), ionomycin, and the phorbol ester, tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	263-292	heat shock protein family A (Hsp70) member 4	Homo sapiens	118-123
11287749-1	2001	Treatment of cultured human hepatoma HepG2 cells with the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), results in an increase in tyrosine phosphorylation of several proteins, including the focal adhesion kinase (FAK) and paxillin using anti-phosphotyrosine Western blotting and immunoprecipitation.	Tetradecanoylphorbol Acetate	92-128	paxillin	Homo sapiens	254-262
1991991-2	1991	In this study, we investigated the effect of BHA on the activity of ornithine decarboxylase (ODC, an indicator of tumor promotion) and its gene expression induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in mouse skin.	Tetradecanoylphorbol Acetate	166-203	ornithine decarboxylase, structural 1	Mus musculus	68-91
11287749-1	2001	Treatment of cultured human hepatoma HepG2 cells with the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), results in an increase in tyrosine phosphorylation of several proteins, including the focal adhesion kinase (FAK) and paxillin using anti-phosphotyrosine Western blotting and immunoprecipitation.	Tetradecanoylphorbol Acetate	130-133	paxillin	Homo sapiens	254-262
1991991-2	1991	In this study, we investigated the effect of BHA on the activity of ornithine decarboxylase (ODC, an indicator of tumor promotion) and its gene expression induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in mouse skin.	Tetradecanoylphorbol Acetate	166-203	ornithine decarboxylase, structural 1	Mus musculus	93-96
1991991-2	1991	In this study, we investigated the effect of BHA on the activity of ornithine decarboxylase (ODC, an indicator of tumor promotion) and its gene expression induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in mouse skin.	Tetradecanoylphorbol Acetate	205-208	ornithine decarboxylase, structural 1	Mus musculus	68-91
11238722-4	2001	TPA treatment results in phosphorylation of cAMP responsive element binding protein (CREB) and activation of cAMP-dependent protein kinase (PKA) in PC12 cells; hence, we tested whether CREB and/or PKA are essential for the TPA response.	Tetradecanoylphorbol Acetate	0-3	cAMP responsive element binding protein 1	Rattus norvegicus	44-83
1991991-3	1991	TPA-induced ODC activity was markedly inhibited by the topical application of 55 mumol of BHA (the inhibition rate at 6 h was about 80%).	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	12-15
1991991-4	1991	In Northern and dot-blot analysis, the TPA-induced increase in ODC mRNA was shown to be markedly reduced by the same dose of BHA (the inhibition rate at 4 h was about 60%).	Tetradecanoylphorbol Acetate	39-42	ornithine decarboxylase, structural 1	Mus musculus	63-66
11238722-4	2001	TPA treatment results in phosphorylation of cAMP responsive element binding protein (CREB) and activation of cAMP-dependent protein kinase (PKA) in PC12 cells; hence, we tested whether CREB and/or PKA are essential for the TPA response.	Tetradecanoylphorbol Acetate	0-3	cAMP responsive element binding protein 1	Rattus norvegicus	85-89
11238722-4	2001	TPA treatment results in phosphorylation of cAMP responsive element binding protein (CREB) and activation of cAMP-dependent protein kinase (PKA) in PC12 cells; hence, we tested whether CREB and/or PKA are essential for the TPA response.	Tetradecanoylphorbol Acetate	0-3	cAMP responsive element binding protein 1	Rattus norvegicus	185-189
1899335-2	1991	Upon functional activation of granulocytes by 4 beta-phorbol 12-myristate 13-acetate (PMA), the levels of c-jun, jun B and jun D transcripts were increased.	Tetradecanoylphorbol Acetate	46-84	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-111
11238722-5	2001	In CREB-deficient cells, the response of the full TH gene proximal promoter or the independent response of the TH CRE by itself to TPA is inhibited.	Tetradecanoylphorbol Acetate	131-134	cAMP responsive element binding protein 1	Rattus norvegicus	3-7
1899335-2	1991	Upon functional activation of granulocytes by 4 beta-phorbol 12-myristate 13-acetate (PMA), the levels of c-jun, jun B and jun D transcripts were increased.	Tetradecanoylphorbol Acetate	86-89	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-111
11238722-6	2001	The TPA-inducibility of TH mRNA is also blocked in CREB-deficient cells.	Tetradecanoylphorbol Acetate	4-7	cAMP responsive element binding protein 1	Rattus norvegicus	51-55
1985780-3	1991	A factor reduction similar to that caused by activated Ha-ras was transiently obtained with 12-O-tetradecanoylphorbol-13-acetate in the PB-3c cells expressing normal c-Ha-ras.	Tetradecanoylphorbol Acetate	92-128	Harvey rat sarcoma virus oncogene	Mus musculus	55-61
1985780-4	1991	The analogous stimulation of protein kinase C (PKC) in PB-3c cells producing oncogenic Ha-ras led to an additional reduction of the IL-3 requirement during the first 24 h. In the absence of IL-3, the prolonged exposure of the cells to 12-O-tetradecanoylphorbol-13-acetate for 72 h resulted in a stimulation of growth when activated but not when normal Ha-ras was expressed.	Tetradecanoylphorbol Acetate	235-271	Harvey rat sarcoma virus oncogene	Mus musculus	87-93
1985780-6	1991	Upon 12-O-tetradecanoylphorbol-13-acetate treatment, a protracted down-regulation of the immunodetectable alpha-PKC as well as constitutively high levels of c-fos mRNA were observed when oncogenic Ha-ras was expressed.	Tetradecanoylphorbol Acetate	5-41	Harvey rat sarcoma virus oncogene	Mus musculus	197-203
1545132-4	1992	Mobility shift assays showed that addition of anti-AIM mAb to PMA-treated T lymphocytes markedly enhanced the binding activity of AP-1 to its cognate sequence, the phorbol ester response element.	Tetradecanoylphorbol Acetate	62-65	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-134
11208605-3	2001	These phosphorylations were attenuated by pretreatment with pertussis toxin (PTX) or by treatment with the phosphotyrosine kinase (PTK) inhibitors genistein and herbimycin, the phosphatidylinositol-specific phospholipase C (PI-PLC) inhibitor U-73122, or the protein kinase C (PKC) inhibitor GF109203X and were enhanced by the PKC activator phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	340-371	phosphatidylinositol-specific phospholipase C	Bos taurus	177-222
1373430-5	1992	The extracellular release of CLC protein was studied during the degranulation of basophils stimulated by anti-immunoglobulin E (anti-IgE), N-formyl-methionyl-leucyl-phenylalanine (fMLP), phorbol myristate acetate, eosinophil major basic protein (MBP), and calcium ionophore A23187.	Tetradecanoylphorbol Acetate	187-212	Charcot-Leyden crystal galectin	Homo sapiens	29-32
1374838-7	1992	The effect of the DHPs was stereospecific; (+)Bay K 8644, a Ca2+ antagonist, inhibited PMA-induced increases in c-fos and NGFI-A mRNAs.	Tetradecanoylphorbol Acetate	87-90	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	112-117
1313435-1	1992	Neutrophils stimulated with 4 beta-phorbol 12-myristate 13-acetate (PMA) release large quantities of superoxide (O2-) and exhibit phosphorylation of two proteins with molecular masses of 47(p47) and 49 kDa (p49).	Tetradecanoylphorbol Acetate	28-66	serum response factor binding protein 1	Homo sapiens	207-210
1313435-1	1992	Neutrophils stimulated with 4 beta-phorbol 12-myristate 13-acetate (PMA) release large quantities of superoxide (O2-) and exhibit phosphorylation of two proteins with molecular masses of 47(p47) and 49 kDa (p49).	Tetradecanoylphorbol Acetate	68-71	serum response factor binding protein 1	Homo sapiens	207-210
1312373-3	1992	Analysis of the subcellular fractionation of unstimulated cells by Western blotting of isopycnic sucrose density gradient fractions with anti-Rap1 peptide antibodies indicated that Rap1A colocalized with cytochrome b in the plasma membrane as well as in the specific granule membranes and that it was translocated, along with cytochrome b, to the plasma membrane when the cells were stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	399-424	mitochondrially encoded cytochrome b	Homo sapiens	204-216
1312373-3	1992	Analysis of the subcellular fractionation of unstimulated cells by Western blotting of isopycnic sucrose density gradient fractions with anti-Rap1 peptide antibodies indicated that Rap1A colocalized with cytochrome b in the plasma membrane as well as in the specific granule membranes and that it was translocated, along with cytochrome b, to the plasma membrane when the cells were stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	426-429	mitochondrially encoded cytochrome b	Homo sapiens	204-216
1537859-7	1992	To examine whether PKC-zeta was activated by TPA, PKC activity was evaluated in COS cells transiently over-expressing this isoform.	Tetradecanoylphorbol Acetate	45-48	protein kinase C zeta	Homo sapiens	19-27
1547524-1	1992	A single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin caused an induction of epidermal ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	32-68	ornithine decarboxylase, structural 1	Mus musculus	122-145
1547524-1	1992	A single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin caused an induction of epidermal ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	32-68	ornithine decarboxylase, structural 1	Mus musculus	147-150
1547524-1	1992	A single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin caused an induction of epidermal ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	70-73	ornithine decarboxylase, structural 1	Mus musculus	122-145
1547524-1	1992	A single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin caused an induction of epidermal ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	70-73	ornithine decarboxylase, structural 1	Mus musculus	147-150
1547524-2	1992	When mice were topically pretreated with staurosporine, a most potent protein kinase C inhibitor, 6-84 h prior to TPA treatment, TPA-caused ODC induction was markedly enhanced.	Tetradecanoylphorbol Acetate	114-117	ornithine decarboxylase, structural 1	Mus musculus	140-143
1547524-2	1992	When mice were topically pretreated with staurosporine, a most potent protein kinase C inhibitor, 6-84 h prior to TPA treatment, TPA-caused ODC induction was markedly enhanced.	Tetradecanoylphorbol Acetate	129-132	ornithine decarboxylase, structural 1	Mus musculus	140-143
1547524-3	1992	The enhancement of TPA-caused ODC induction by staurosporine was most pronounced when the time interval between staurosporine and TPA treatment was 36 h. Staurosporine elicited this enhancing effect in a dose-related manner.	Tetradecanoylphorbol Acetate	19-22	ornithine decarboxylase, structural 1	Mus musculus	30-33
1547524-3	1992	The enhancement of TPA-caused ODC induction by staurosporine was most pronounced when the time interval between staurosporine and TPA treatment was 36 h. Staurosporine elicited this enhancing effect in a dose-related manner.	Tetradecanoylphorbol Acetate	130-133	ornithine decarboxylase, structural 1	Mus musculus	30-33
1547524-6	1992	Although staurosporine markedly augmented TPA-caused ODC induction, staurosporine-caused ODC induction was not augmented by this compound.	Tetradecanoylphorbol Acetate	42-45	ornithine decarboxylase, structural 1	Mus musculus	53-56
1547524-8	1992	These results indicate that the enhancement of ODC induction by staurosporine is specific for the induction caused by TPA and that this enhancing effect is not related to the protein kinase C inhibitory action of staurosporine.	Tetradecanoylphorbol Acetate	118-121	ornithine decarboxylase, structural 1	Mus musculus	47-50
1547524-9	1992	TPA-caused epidermal ODC induction was inhibited by indomethacin, and this inhibition was reversed by prostaglandin E2 (PGE2).	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	21-24
1310679-4	1992	In primary cultures of dog thyrocytes, dedifferentiation of the cells by treatment with epidermal growth factor or 12-O-tetradecanoylphorbol-13-acetate led to decreased TSHr mRNA levels and nearly abolished thyroglobulin and TPO gene expression.	Tetradecanoylphorbol Acetate	115-151	thyroid stimulating hormone receptor	Canis lupus familiaris	169-173
1737059-5	1992	The combination of phorbol myristate acetate (PMA) and ionomycin also stimulated ODC activity in these cells.	Tetradecanoylphorbol Acetate	19-44	ornithine decarboxylase, structural 1	Mus musculus	81-84
1737059-5	1992	The combination of phorbol myristate acetate (PMA) and ionomycin also stimulated ODC activity in these cells.	Tetradecanoylphorbol Acetate	46-49	ornithine decarboxylase, structural 1	Mus musculus	81-84
1737059-6	1992	The anti-oxidants DES, NDGA and ferricyanide strongly inhibited the increase in ODC activity seen in response to either concanavalin A or PMA/ionomycin.	Tetradecanoylphorbol Acetate	138-141	ornithine decarboxylase, structural 1	Mus musculus	80-83
1532767-4	1992	In Ad5 E1A and Ad5 E1A + low-level beta 1 PKC expressing CREF clones, the tumor promoting agent 12-0-tetradecanoyl-phorbol-13-acetate (TPA) further enhances anchorage-independence.	Tetradecanoylphorbol Acetate	135-138	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	19-22
1532767-11	1992	In addition, the combination of a transfected Ad5 E1A and a beta 1 PKC gene in the same CREF clone results in an enhanced expression of the transformed phenotype in both the absence and presence of TPA.	Tetradecanoylphorbol Acetate	198-201	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	50-53
1309563-5	1992	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated c-fos expression but did not trigger cell proliferation.	Tetradecanoylphorbol Acetate	51-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	67-72
1543678-8	1992	In vivo treatment with the phorbol ester TPA rapidly elevates uterine levels of fos, jun, and myc transcripts, indicating that expression of these protooncogenes is under non-estrogenic as well as estrogenic regulation in this target tissue.	Tetradecanoylphorbol Acetate	41-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	80-83
1576243-0	1992	Characterization of the inhibition of interleukin 2 mRNA accumulation by 12-O-tetradecanoylphorbol-13-acetate in primary lymphocytes.	Tetradecanoylphorbol Acetate	73-109	interleukin 2	Bos taurus	38-51
1576243-4	1992	In this study we further characterized how TPA pretreatment affected IL-2 mRNA production.	Tetradecanoylphorbol Acetate	43-46	interleukin 2	Bos taurus	69-73
1576243-5	1992	We found that TPA depressed IL-2 mRNA accumulation in a dose-dependent manner after at least 10 h of pretreatment.	Tetradecanoylphorbol Acetate	14-17	interleukin 2	Bos taurus	28-32
1576243-7	1992	Furthermore, LNC stimulated with ionomycin plus TPA were less susceptible to inhibition by pretreatment with TPA, most likely because this mitogenic combination caused a much greater amount of IL-2 mRNA than did Con A or Con A plus TPA.	Tetradecanoylphorbol Acetate	48-51	interleukin 2	Bos taurus	193-197
1314957-5	1992	An early rise in VDR abundance occurred at 4 h, followed by a decrease and then a broad secondary rise at 18 h. At the mRNA level, forskolin caused a rapid rise in VDR transcripts after 1 h of exposure, a peak at 2 h, followed by a decline and a subsequent increase at 15 h. Activation of PK-C with the phorbol ester phorbol myristate acetate abolished the forskolin-induced increase in VDR protein and mRNA abundance.	Tetradecanoylphorbol Acetate	317-342	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	17-20
1314957-5	1992	An early rise in VDR abundance occurred at 4 h, followed by a decrease and then a broad secondary rise at 18 h. At the mRNA level, forskolin caused a rapid rise in VDR transcripts after 1 h of exposure, a peak at 2 h, followed by a decline and a subsequent increase at 15 h. Activation of PK-C with the phorbol ester phorbol myristate acetate abolished the forskolin-induced increase in VDR protein and mRNA abundance.	Tetradecanoylphorbol Acetate	317-342	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	164-167
1314957-5	1992	An early rise in VDR abundance occurred at 4 h, followed by a decrease and then a broad secondary rise at 18 h. At the mRNA level, forskolin caused a rapid rise in VDR transcripts after 1 h of exposure, a peak at 2 h, followed by a decline and a subsequent increase at 15 h. Activation of PK-C with the phorbol ester phorbol myristate acetate abolished the forskolin-induced increase in VDR protein and mRNA abundance.	Tetradecanoylphorbol Acetate	317-342	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	164-167
1314957-8	1992	Up- or down-regulation of VDR in these transfected cells by forskolin or phorbol myristate acetate pretreatment, respectively, resulted in corresponding enhancement or attenuation of 1,25-(OH)2D3-inducible CAT activity.	Tetradecanoylphorbol Acetate	73-98	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	26-29
1371192-2	1992	It is demonstrated that the binding of IgG2a and IgG2b but not IgG1 and IgG3 augments the biosynthesis of C3 both in the presence and in the absence of the phorbol ester, phorbol myristate acetate in the case of both cell types.	Tetradecanoylphorbol Acetate	171-196	immunoglobulin heavy constant gamma 2B	Mus musculus	49-54
1617422-0	1992	Activation of nerve growth factor synthesis in primary glial cells by phorbol 12-myristate 13-acetate: role of protein kinase C. Phorbol 12-myristate 13-acetate (PMA) induces a dramatic production of nerve growth factor (NGF) in primary cultures of newborn mouse astrocytes maintained in a serum-free medium.	Tetradecanoylphorbol Acetate	70-101	nerve growth factor	Mus musculus	14-33
1617422-0	1992	Activation of nerve growth factor synthesis in primary glial cells by phorbol 12-myristate 13-acetate: role of protein kinase C. Phorbol 12-myristate 13-acetate (PMA) induces a dramatic production of nerve growth factor (NGF) in primary cultures of newborn mouse astrocytes maintained in a serum-free medium.	Tetradecanoylphorbol Acetate	70-101	nerve growth factor	Mus musculus	200-219
1617422-0	1992	Activation of nerve growth factor synthesis in primary glial cells by phorbol 12-myristate 13-acetate: role of protein kinase C. Phorbol 12-myristate 13-acetate (PMA) induces a dramatic production of nerve growth factor (NGF) in primary cultures of newborn mouse astrocytes maintained in a serum-free medium.	Tetradecanoylphorbol Acetate	70-101	nerve growth factor	Mus musculus	221-224
1617422-0	1992	Activation of nerve growth factor synthesis in primary glial cells by phorbol 12-myristate 13-acetate: role of protein kinase C. Phorbol 12-myristate 13-acetate (PMA) induces a dramatic production of nerve growth factor (NGF) in primary cultures of newborn mouse astrocytes maintained in a serum-free medium.	Tetradecanoylphorbol Acetate	129-160	nerve growth factor	Mus musculus	14-33
1617422-0	1992	Activation of nerve growth factor synthesis in primary glial cells by phorbol 12-myristate 13-acetate: role of protein kinase C. Phorbol 12-myristate 13-acetate (PMA) induces a dramatic production of nerve growth factor (NGF) in primary cultures of newborn mouse astrocytes maintained in a serum-free medium.	Tetradecanoylphorbol Acetate	129-160	nerve growth factor	Mus musculus	200-219
1617422-0	1992	Activation of nerve growth factor synthesis in primary glial cells by phorbol 12-myristate 13-acetate: role of protein kinase C. Phorbol 12-myristate 13-acetate (PMA) induces a dramatic production of nerve growth factor (NGF) in primary cultures of newborn mouse astrocytes maintained in a serum-free medium.	Tetradecanoylphorbol Acetate	129-160	nerve growth factor	Mus musculus	221-224
1617422-0	1992	Activation of nerve growth factor synthesis in primary glial cells by phorbol 12-myristate 13-acetate: role of protein kinase C. Phorbol 12-myristate 13-acetate (PMA) induces a dramatic production of nerve growth factor (NGF) in primary cultures of newborn mouse astrocytes maintained in a serum-free medium.	Tetradecanoylphorbol Acetate	162-165	nerve growth factor	Mus musculus	14-33
1617422-0	1992	Activation of nerve growth factor synthesis in primary glial cells by phorbol 12-myristate 13-acetate: role of protein kinase C. Phorbol 12-myristate 13-acetate (PMA) induces a dramatic production of nerve growth factor (NGF) in primary cultures of newborn mouse astrocytes maintained in a serum-free medium.	Tetradecanoylphorbol Acetate	162-165	nerve growth factor	Mus musculus	200-219
1617422-0	1992	Activation of nerve growth factor synthesis in primary glial cells by phorbol 12-myristate 13-acetate: role of protein kinase C. Phorbol 12-myristate 13-acetate (PMA) induces a dramatic production of nerve growth factor (NGF) in primary cultures of newborn mouse astrocytes maintained in a serum-free medium.	Tetradecanoylphorbol Acetate	162-165	nerve growth factor	Mus musculus	221-224
1730592-3	1992	Using this antiserum for quantitative determination of the 80-kDa MARCKS-related protein, we found that the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a rapid down-regulation of this protein in the fibroblasts.	Tetradecanoylphorbol Acetate	122-158	myristoylated alanine rich protein kinase C substrate	Mus musculus	66-72
1730592-3	1992	Using this antiserum for quantitative determination of the 80-kDa MARCKS-related protein, we found that the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a rapid down-regulation of this protein in the fibroblasts.	Tetradecanoylphorbol Acetate	160-163	myristoylated alanine rich protein kinase C substrate	Mus musculus	66-72
1730592-5	1992	Staurosporine also suppresses the TPA-induced down-regulation, possibly indicating that the down-regulation of the MARCKS-related protein is dependent on its phosphorylation by protein kinase C.	Tetradecanoylphorbol Acetate	34-37	myristoylated alanine rich protein kinase C substrate	Mus musculus	115-121
11536950-6	1992	Under simulated weightlessness conditions EGF- and TPA-induced c-fos expression was decreased, while forskolin- and A23187-induced c-fos expression was independent of the gravity conditions.	Tetradecanoylphorbol Acetate	51-54	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-68
1733233-7	1992	Phorbol myristate acetate enhanced MRP-14 mRNA levels to a greater extent than MRP-8 mRNA levels, suggesting differential regulation of MRP gene expression by protein kinase C. The 1,25-(OH)2D3-induced relative increase in MRP mRNA levels was not changed by a 1,000-fold reduction in extracellular [Ca2+].	Tetradecanoylphorbol Acetate	0-25	S100 calcium binding protein A9	Homo sapiens	35-41
1294024-9	1992	The UV-induced effect on tyrosinase activity was higher in melanocytes cultured with BPE than in those cultured with TPA.	Tetradecanoylphorbol Acetate	117-120	tyrosinase	Homo sapiens	25-35
1312200-5	1992	Treatment of the C6 cells with phorbol 12-myristate 13-acetate caused a 13-fold increase in c-fos expression 0.5 h after administration and a decrease in proenkephalin mRNA.	Tetradecanoylphorbol Acetate	31-62	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-97
1531763-2	1992	High in vitro growth ability was observed in response to recombinant human IL-2 (rIL-2) and human rIL-7, both in the absence of any co-mitogen and in combination with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	200-203	interleukin 7	Rattus norvegicus	98-103
1313115-10	1992	Induction of c-fos mRNA by the phorbol ester, PMA, or by dioctanoyl glycerol, however, had no effect on Na,K-ATPase activity.	Tetradecanoylphorbol Acetate	46-49	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-18
1670943-0	1991	Phorbol myristate acetate-activated keratinocytes stimulate proliferation of resting peripheral blood mononuclear lymphocytes via a MHC-independent, but protein kinase C- and intercellular adhesion molecule-1-dependent, mechanism.	Tetradecanoylphorbol Acetate	0-25	intercellular adhesion molecule 1	Homo sapiens	175-208
1825556-0	1991	Effect of dexamethasone and phorbol myristate acetate on lipocortin 1, 2 and 5 mRNA and protein synthesis.	Tetradecanoylphorbol Acetate	28-53	annexin A1	Homo sapiens	57-78
1838253-9	1991	Treatment of cells known to activate the protein kinase C (TPA) and inositol triphosphate pathways has increased the level of beta-MHC mRNA while that of alpha-MHC remained unchanged.	Tetradecanoylphorbol Acetate	59-62	major histocompatibility complex, class I, C	Homo sapiens	131-134
1988078-4	1991	Assessment of total PKC specific activity revealed that translocation induced by TPA and the two nonphorbol activators was not associated with PKC degradation in hepatocytes from either control or PB-exposed rats.	Tetradecanoylphorbol Acetate	81-84	protein kinase C, gamma	Rattus norvegicus	20-23
1988078-7	1991	However, both the diminished epidermal growth factor receptor response and the inhibition of TPA-induced PKC translocation were reversed by withdrawal of PB for 2 to 4 weeks.	Tetradecanoylphorbol Acetate	93-96	protein kinase C, gamma	Rattus norvegicus	105-108
1720762-0	1991	Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels.	Tetradecanoylphorbol Acetate	0-31	glial fibrillary acidic protein	Homo sapiens	79-110
1720762-0	1991	Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels.	Tetradecanoylphorbol Acetate	0-31	glial fibrillary acidic protein	Homo sapiens	112-116
1720762-0	1991	Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels.	Tetradecanoylphorbol Acetate	33-36	glial fibrillary acidic protein	Homo sapiens	79-110
1720762-0	1991	Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels.	Tetradecanoylphorbol Acetate	33-36	glial fibrillary acidic protein	Homo sapiens	112-116
1720762-10	1991	These studies demonstrate that in the U-373MG cells, protein kinase C inhibitors and long treatment with PMA result in a decrease in steady-state GFAP mRNA.	Tetradecanoylphorbol Acetate	105-108	glial fibrillary acidic protein	Homo sapiens	146-150
27463352-5	1991	The expression of ND2 mRNA decreased in HL60 cells several hours after treatment with phorbol myristate acetate (PMA), or dimethyl sulfoxide (DMSO).	Tetradecanoylphorbol Acetate	86-111	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	18-21
27463352-5	1991	The expression of ND2 mRNA decreased in HL60 cells several hours after treatment with phorbol myristate acetate (PMA), or dimethyl sulfoxide (DMSO).	Tetradecanoylphorbol Acetate	113-116	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	18-21
1824713-4	1991	AP-1 binds to 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive elements (TREs); therefore, E1A might modulate a specific signal transduction pathway normally induced by activation of the protein kinase C. Binding of jun/AP-1 to a TRE is induced in all cell types studied when E1A is expressed.	Tetradecanoylphorbol Acetate	14-50	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
1824713-4	1991	AP-1 binds to 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive elements (TREs); therefore, E1A might modulate a specific signal transduction pathway normally induced by activation of the protein kinase C. Binding of jun/AP-1 to a TRE is induced in all cell types studied when E1A is expressed.	Tetradecanoylphorbol Acetate	52-55	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
1824713-4	1991	AP-1 binds to 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive elements (TREs); therefore, E1A might modulate a specific signal transduction pathway normally induced by activation of the protein kinase C. Binding of jun/AP-1 to a TRE is induced in all cell types studied when E1A is expressed.	Tetradecanoylphorbol Acetate	52-55	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	225-229
1704120-3	1991	C-fos in SMS-SB cells can still be induced by serum, TPA and the calcium ionophore, A23187, and superinduced by the combination of serum and cycloheximide.	Tetradecanoylphorbol Acetate	53-56	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
1844247-9	1991	Prolonged treatment of R6 cells with TPA caused total loss of cPKC alpha, nPKC delta and nPKC zeta but only a 60% reduction in nPKC epsilon.	Tetradecanoylphorbol Acetate	37-40	protein kinase C zeta	Homo sapiens	89-98
2174010-7	1990	On the contrary, P20 and P47 phosphorylation induced by 50 nM of 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C, was significantly decreased in the DM-A group.	Tetradecanoylphorbol Acetate	65-101	tubulin polymerization promoting protein family member 3	Homo sapiens	17-20
2148567-2	1990	CAP-23 was a substrate for purified protein kinase C (PKC) in vitro, and the protein was phosphorylated in a PMA-sensitive manner in cultured cells, indicating that it is a PKC substrate in situ.	Tetradecanoylphorbol Acetate	109-112	brain abundant membrane attached signal protein 1	Gallus gallus	0-6
2243505-3	1990	Both actinomycin-D and cycloheximide could abrogate PMA-induced p55 membrane expression, suggesting the need for de novo mRNA and protein synthesis.	Tetradecanoylphorbol Acetate	52-55	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	64-67
2256925-0	1990	Regulation of creatine phosphokinase B activity by protein kinase C. We previously reported that topical application of 12-o-tetradecanoylphorbol-13-acetate to mouse skin causes phosphorylation of epidermal proteins with molecular weights of 40,000 (p40) and 34,000 (p34).	Tetradecanoylphorbol Acetate	120-156	interleukin 12b	Mus musculus	250-253
1699748-5	1990	Increase in right atrial pressure in the presence of a phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), known to stimulate protein kinase C activity in heart cells, resulted in a significantly greater increase in the perfusate IR-ANP concentration than after vehicle infusion.	Tetradecanoylphorbol Acetate	70-107	natriuretic peptide A	Rattus norvegicus	241-244
1699748-5	1990	Increase in right atrial pressure in the presence of a phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), known to stimulate protein kinase C activity in heart cells, resulted in a significantly greater increase in the perfusate IR-ANP concentration than after vehicle infusion.	Tetradecanoylphorbol Acetate	109-112	natriuretic peptide A	Rattus norvegicus	241-244
1699748-6	1990	The calculated ANP increase corresponding to the 2 mm Hg increase in the right atrial pressure was 1.52-fold in the control group and 1.84-fold when 10 nM TPA was infused (P less than 0.05).	Tetradecanoylphorbol Acetate	155-158	natriuretic peptide A	Rattus norvegicus	15-18
1699748-7	1990	Infusion of TPA at a dose of 24 nM further increased the stretch-induced ANP release by causing 2.22-fold (P less than 0.01) increase in IR-ANP secretion.	Tetradecanoylphorbol Acetate	12-15	natriuretic peptide A	Rattus norvegicus	73-76
1699748-7	1990	Infusion of TPA at a dose of 24 nM further increased the stretch-induced ANP release by causing 2.22-fold (P less than 0.01) increase in IR-ANP secretion.	Tetradecanoylphorbol Acetate	12-15	natriuretic peptide A	Rattus norvegicus	140-143
2172787-2	1990	E1A abolished the transactivating function of AP-1 (Jun/Fos), which binds to the 12-O-tetradecanoylphorbol-13-acetate-responsive element of the collagenase gene (collTRE).	Tetradecanoylphorbol Acetate	81-117	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	56-59
2233279-0	1990	Protein kinase C inhibitors block insulin and PMA-stimulated hexose transport in isolated rat adipocytes and BC3H-1 myocytes.	Tetradecanoylphorbol Acetate	46-49	protein kinase C, gamma	Rattus norvegicus	0-16
2233279-2	1990	In both model systems, H-7, sangivamycin, and staurosporine, inhibitors of the catalytic domain of PKC, each effectively blocked insulin and PMA-stimulated hexose uptake at similar concentrations.	Tetradecanoylphorbol Acetate	141-144	protein kinase C, gamma	Rattus norvegicus	99-102
2148532-8	1990	Protein kinase C activation by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulated ANP secretion from the atrial myocytes, while the ventricular myocytes were unresponsive to TPA.	Tetradecanoylphorbol Acetate	31-68	natriuretic peptide A	Rattus norvegicus	86-89
2148532-8	1990	Protein kinase C activation by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulated ANP secretion from the atrial myocytes, while the ventricular myocytes were unresponsive to TPA.	Tetradecanoylphorbol Acetate	70-73	natriuretic peptide A	Rattus norvegicus	86-89
2208302-2	1990	GM-CSF expression (biological activity and mRNA level) was maximum after culturing the lymphocytes for 45 hr with concanavalin A and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	133-158	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-6
2211670-1	1990	Treatment of a variety of cells and tissues with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C (PKC) results in the inhibition of receptor-coupled inositol phospholipid-specific phospholipase C (PLC) activity.	Tetradecanoylphorbol Acetate	49-85	protein kinase C, gamma	Rattus norvegicus	109-125
2211670-1	1990	Treatment of a variety of cells and tissues with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C (PKC) results in the inhibition of receptor-coupled inositol phospholipid-specific phospholipase C (PLC) activity.	Tetradecanoylphorbol Acetate	49-85	protein kinase C, gamma	Rattus norvegicus	127-130
2211670-1	1990	Treatment of a variety of cells and tissues with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C (PKC) results in the inhibition of receptor-coupled inositol phospholipid-specific phospholipase C (PLC) activity.	Tetradecanoylphorbol Acetate	87-90	protein kinase C, gamma	Rattus norvegicus	109-125
2211670-1	1990	Treatment of a variety of cells and tissues with 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C (PKC) results in the inhibition of receptor-coupled inositol phospholipid-specific phospholipase C (PLC) activity.	Tetradecanoylphorbol Acetate	87-90	protein kinase C, gamma	Rattus norvegicus	127-130
2209721-0	1990	Alterations of cell cycle kinetics and vimentin expression in TPA-treated, asynchronous MPC-11 mouse plasmacytoma cells.	Tetradecanoylphorbol Acetate	62-65	vimentin	Mus musculus	39-47
2209721-3	1990	In the presence of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), cell proliferation ceases and large quantities of the intermediate filament protein vimentin are synthesized and accumulate in most of the cells.	Tetradecanoylphorbol Acetate	37-73	vimentin	Mus musculus	165-173
2209721-3	1990	In the presence of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), cell proliferation ceases and large quantities of the intermediate filament protein vimentin are synthesized and accumulate in most of the cells.	Tetradecanoylphorbol Acetate	75-78	vimentin	Mus musculus	165-173
2209721-8	1990	Vimentin accumulation could be detected by flow cytometry as early as 2 h after TPA addition; at this time, the percentage of vimentin-positive cells was highest in G2/M phase.	Tetradecanoylphorbol Acetate	80-83	vimentin	Mus musculus	0-8
2209721-9	1990	Prolonged TPA treatment induced vimentin accumulation in cells of all cell cycle phases.	Tetradecanoylphorbol Acetate	10-13	vimentin	Mus musculus	32-40
2209721-11	1990	The fraction of cells which displayed a higher level of vimentin probably represents those G1-phase cells which previously had undergone cell division in the presence of TPA.	Tetradecanoylphorbol Acetate	170-173	vimentin	Mus musculus	56-64
2209721-12	1990	Our data indicate that TPA-induced vimentin synthesis is regulated in a cell cycle-dependent manner and is maximally induced in cells which have passed a putative cell cycle restriction point in G1 phase.	Tetradecanoylphorbol Acetate	23-26	vimentin	Mus musculus	35-43
18475453-14	1992	TPA displayed a similar, but more potent amplification of PAF synthesis in response to both BK or the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	0-3	kininogen 1	Bos taurus	92-94
1530879-0	1992	Altered expression of protein kinase C, lck, and CD45 in a 12-O-tetradecanoylphorbol-13-acetate-dependent leukemic T-cell variant that expresses a high level of interleukin-2 receptor.	Tetradecanoylphorbol Acetate	59-95	protein tyrosine phosphatase receptor type C	Homo sapiens	49-53
1530879-2	1992	By selecting for growth in the presence of TPA, we have isolated two TPA-resistant variants of these cells, P13-50 and P13-5/A8.	Tetradecanoylphorbol Acetate	43-46	dynactin subunit 1	Homo sapiens	108-113
1530879-2	1992	By selecting for growth in the presence of TPA, we have isolated two TPA-resistant variants of these cells, P13-50 and P13-5/A8.	Tetradecanoylphorbol Acetate	69-72	dynactin subunit 1	Homo sapiens	108-113
1530879-5	1992	The P13-5/A8 cells are of particular interest because not only are they resistant to TPA toxicity but they actually require TPA for optimal growth.	Tetradecanoylphorbol Acetate	85-88	dynactin subunit 1	Homo sapiens	4-9
1530879-5	1992	The P13-5/A8 cells are of particular interest because not only are they resistant to TPA toxicity but they actually require TPA for optimal growth.	Tetradecanoylphorbol Acetate	124-127	dynactin subunit 1	Homo sapiens	4-9
1543542-5	1992	The expression of jun and fos gene family members, which make up the AP-1 complex, can be stimulated by serum and a number of growth factors, including EGF, and by TPA.	Tetradecanoylphorbol Acetate	164-167	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	26-29
1543542-7	1992	The data presented here demonstrate both similarities and differences in the basal and TPA- or EGF-induced levels of fos and jun family members between P+ and P- cells.	Tetradecanoylphorbol Acetate	87-90	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	117-120
1543542-8	1992	The most striking observation was that the overall TPA- and EGF-induced levels of jun but not fos expression were higher in P+ cells.	Tetradecanoylphorbol Acetate	51-54	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	94-97
1408948-6	1992	Similarly, the topical application of EGCG resulted in significant inhibition (p less than 0.005) in TPA-caused induction of epidermal ODC activity.	Tetradecanoylphorbol Acetate	101-104	ornithine decarboxylase, structural 1	Mus musculus	135-138
1450490-4	1992	Thus, treatment of cells with TPA results in a reduction in the levels of c-myb and c-myc mRNA, while the expression of c-fos, c-jun, and junB is greatly enhanced.	Tetradecanoylphorbol Acetate	30-33	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-125
1450490-4	1992	Thus, treatment of cells with TPA results in a reduction in the levels of c-myb and c-myc mRNA, while the expression of c-fos, c-jun, and junB is greatly enhanced.	Tetradecanoylphorbol Acetate	30-33	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	127-132
1450490-5	1992	Immunoprecipitation experiments also demonstrate a TPA induced increase in the c-jun protein in both sensitive and resistant cells.	Tetradecanoylphorbol Acetate	51-54	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-84
1450490-9	1992	These studies therefore demonstrate that HL-60/Vinc cells are defective in the TPA induction of a functional AP-1 complex and that this may account for the inability of these cells to differentiate to macrophages.	Tetradecanoylphorbol Acetate	79-82	nuclear paraspeckle assembly transcript 1	Homo sapiens	47-51
2254963-6	1990	Incubation of brain slices with [32P]-orthophosphate and the protein kinase C activator phorbol 12-myristate 13-acetate or forskolin, an activator of cyclic AMP-dependent protein kinase, stimulated phosphorylation of GFAP.	Tetradecanoylphorbol Acetate	88-119	glial fibrillary acidic protein	Homo sapiens	217-221
11156944-5	2001	Here, we demonstrate that PMA induces both reactive oxygen species (ROS) generation and TNF p75 receptor shedding in Mono Mac 6 cells, a human monocytic cell line, and l-selectin shedding in Jurkat T-cells.	Tetradecanoylphorbol Acetate	26-29	selectin L	Homo sapiens	168-178
2118993-4	1990	Stimulation of DNA synthesis by epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) was completely blocked by p21(Asn-17) expression, and stimulation by serum, fibroblast growth factor, and platelet-derived growth factor was partially inhibited.	Tetradecanoylphorbol Acetate	66-102	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	135-138
2118993-4	1990	Stimulation of DNA synthesis by epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) was completely blocked by p21(Asn-17) expression, and stimulation by serum, fibroblast growth factor, and platelet-derived growth factor was partially inhibited.	Tetradecanoylphorbol Acetate	104-107	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	135-138
1662619-0	1991	Activation of a keratinocyte phospholipase A2 by bradykinin and 4 beta-phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	64-102	phospholipase A2, group IB, pancreas	Mus musculus	29-45
1662619-4	1991	Three lines of evidence indicate phospholipase A2 activity to be involved in arachidonic acid release: (a) its inhibition by mepacrine, (b) the concomitant generation of lysophosphatidylcholine from [3H]choline-labeled cells and (c) an increase in arachidonic acid release from 14C-labeled phosphatidylcholine in particulate fractions from PMA-treated and bradykinin-treated keratinocytes.	Tetradecanoylphorbol Acetate	340-343	phospholipase A2, group IB, pancreas	Mus musculus	33-49
1720093-6	1991	In contrast, IR-PYY secretion only was stimulated in a synergistic fashion through calcium- and protein kinase-C-dependent pathways (stimulated with A23187 and phorbol myristate acetate, respectively).	Tetradecanoylphorbol Acetate	160-185	peptide YY	Rattus norvegicus	16-19
1721021-5	1991	Prior activation with phorbol 12-myristate 13-acetate (PMA) significantly increased the ability of T cells to up-regulate endothelial ICAM-1 and also induced the expression of both ELAM-1 and VCAM-1.	Tetradecanoylphorbol Acetate	22-53	intercellular adhesion molecule 1	Homo sapiens	134-140
1721021-5	1991	Prior activation with phorbol 12-myristate 13-acetate (PMA) significantly increased the ability of T cells to up-regulate endothelial ICAM-1 and also induced the expression of both ELAM-1 and VCAM-1.	Tetradecanoylphorbol Acetate	55-58	intercellular adhesion molecule 1	Homo sapiens	134-140
2178218-5	1990	PMA inhibited the increase in 3 beta HSD mRNA levels induced by hCG in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-3	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	30-40
11160957-4	2001	METHODS: The authors assessed endogenous CREB phosphorylation in a CLS fibroblast line by Western blotting and found impaired CREB phosphorylation in response to stimulation by EGF and the protein kinase C (PKC) agonist phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	220-251	epidermal growth factor	Homo sapiens	177-180
2118422-0	1990	Ability of the Ca2+ ionophores A23187 and ionomycin to mimic some of the effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production, ornithine decarboxylase activity, and DNA synthesis in mouse epidermis in vivo.	Tetradecanoylphorbol Acetate	103-139	ornithine decarboxylase, structural 1	Mus musculus	169-192
2118422-2	1990	In contrast, these doses of Ca2+ ionophores applied once or twice at a 48-h interval produce only 3-8% of the 16- or 34-fold inductions of epidermal ornithine decarboxylase (ODC) activities caused by similar TPA treatments.	Tetradecanoylphorbol Acetate	208-211	ornithine decarboxylase, structural 1	Mus musculus	174-177
2118422-6	1990	The results suggest that the magnitudes of Ca2+ ionophore- and TPA-induced DNA synthesis may be linked to HPx production rather than ODC induction.	Tetradecanoylphorbol Acetate	63-66	ornithine decarboxylase, structural 1	Mus musculus	133-136
2118525-5	1990	This region contains a sequence that is identical to the -296 element of the human c-fos gene and is homologous with the polyoma enhancer and the cAMP- and 12-O-tetradecanoylphorbol-13-acetate-responsive elements described for several genes.	Tetradecanoylphorbol Acetate	156-192	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-88
1791843-3	1991	It recently has been reported that certain nuclear receptors can antagonize the tumor promoter 12-O-tetradeconylphorbol-13-acetate (TPA) by direct interaction with the transcription factor AP-1, and that the AP-1 constituents cJun and cFos can inhibit receptor activity.	Tetradecanoylphorbol Acetate	132-135	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	189-193
1791843-3	1991	It recently has been reported that certain nuclear receptors can antagonize the tumor promoter 12-O-tetradeconylphorbol-13-acetate (TPA) by direct interaction with the transcription factor AP-1, and that the AP-1 constituents cJun and cFos can inhibit receptor activity.	Tetradecanoylphorbol Acetate	132-135	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	208-212
1791843-3	1991	It recently has been reported that certain nuclear receptors can antagonize the tumor promoter 12-O-tetradeconylphorbol-13-acetate (TPA) by direct interaction with the transcription factor AP-1, and that the AP-1 constituents cJun and cFos can inhibit receptor activity.	Tetradecanoylphorbol Acetate	132-135	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	226-230
1791843-3	1991	It recently has been reported that certain nuclear receptors can antagonize the tumor promoter 12-O-tetradeconylphorbol-13-acetate (TPA) by direct interaction with the transcription factor AP-1, and that the AP-1 constituents cJun and cFos can inhibit receptor activity.	Tetradecanoylphorbol Acetate	132-135	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	235-239
2168226-3	1990	Concentrations of H7 and H8 that inhibited the 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulated upregulation of CD11b expression and activation of the respiratory burst, both augmented the effects of GM-CSF.	Tetradecanoylphorbol Acetate	47-84	integrin subunit alpha M	Homo sapiens	118-123
11160957-4	2001	METHODS: The authors assessed endogenous CREB phosphorylation in a CLS fibroblast line by Western blotting and found impaired CREB phosphorylation in response to stimulation by EGF and the protein kinase C (PKC) agonist phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	253-256	epidermal growth factor	Homo sapiens	177-180
2168226-3	1990	Concentrations of H7 and H8 that inhibited the 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulated upregulation of CD11b expression and activation of the respiratory burst, both augmented the effects of GM-CSF.	Tetradecanoylphorbol Acetate	86-89	integrin subunit alpha M	Homo sapiens	118-123
2401054-9	1990	In a parallel study, ornithine decarboxylase activity, a suggested marker of promotion, was greatly elevated in the epidermis of all TPA-treated mice and the effect of diet tended to reflect the different rates of tumor formation observed among the groups.	Tetradecanoylphorbol Acetate	133-136	ornithine decarboxylase, structural 1	Mus musculus	21-44
1726926-4	1991	bFGF enhanced the secretion of IGFBP-2 and, like epidermal growth factor (EGF) and the tumour promoting phorbol ester (TPA), induced the appearance of IGFBP-3.	Tetradecanoylphorbol Acetate	119-122	insulin-like growth factor-binding protein 3	Ovis aries	151-158
1720402-0	1991	Phorbol 12-myristate-13-acetate (PMA) stimulates a differential expression of cholecystokinin (CCK) and c-fos mRNA in a human neuroblastoma cell line.	Tetradecanoylphorbol Acetate	33-36	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-109
11368020-8	2001	Apoptosis and pRb hypophosphorylation were associated with a reduction in cyclin D1 levels, suggesting that the growth-retarding effects of TPA were produced by modulation of this cell cycle protein.	Tetradecanoylphorbol Acetate	140-143	cyclin D1	Sus scrofa	74-83
1939224-2	1991	We have demonstrated previously that the G protein alpha subunit Gz alpha (or Gx alpha) in human platelets is subject to phosphorylation by agents that activate protein kinase C, including phorbol 12-myristate 13-acetate, thrombin, and the thromboxane A2 analog U46619.	Tetradecanoylphorbol Acetate	189-220	G protein subunit alpha z	Homo sapiens	65-73
11734063-4	2001	RESULTS: PLD2, but not PLD1, mRNA and protein were detected in these cells and endogenous PLD activity and ACh synthesis were stimulated by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	173-176	phospholipase D2	Mus musculus	9-13
1814434-9	1991	Activation of PKC has been implicated in the regulation of certain immediate early response genes, and in the present studies, TPA rapidly induced c-fos and c-jun gene expression.	Tetradecanoylphorbol Acetate	127-130	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	147-152
1974218-2	1990	The phorbol ester, phorbol 12 myristate 13-acetate, caused a concentration-dependent increase in immunoreactive somatostatin secretion with a 1-mumol/L concentration resulting in a 40-fold stimulation (basal 0.28% +/- 0.7% total cell content vs. 13.8% +/- 2.2% TCC, P less than 0.005).	Tetradecanoylphorbol Acetate	19-50	somatostatin	Homo sapiens	112-124
11299067-9	2001	The MOF score and blood TM levels were positively correlated with DIC score, thrombin-AT-III complex and tPA-PAI-1 complex, and negatively correlated with blood platelet count.	Tetradecanoylphorbol Acetate	105-108	thrombomodulin	Homo sapiens	24-26
1966941-5	1990	EL-4 feeder activity was strictly dependent on the presence of phorbol-myristate-acetate (PMA) and supernatant from stimulated T-lymphocytes (T-SN).	Tetradecanoylphorbol Acetate	63-88	epilepsy 4	Mus musculus	0-4
1966941-5	1990	EL-4 feeder activity was strictly dependent on the presence of phorbol-myristate-acetate (PMA) and supernatant from stimulated T-lymphocytes (T-SN).	Tetradecanoylphorbol Acetate	90-93	epilepsy 4	Mus musculus	0-4
1814434-9	1991	Activation of PKC has been implicated in the regulation of certain immediate early response genes, and in the present studies, TPA rapidly induced c-fos and c-jun gene expression.	Tetradecanoylphorbol Acetate	127-130	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-162
1814434-11	1991	Staurosporine, a nonspecific inhibitor of PKC, partially blocked TPA-induced adherence and growth inhibition and concomitantly prevented TPA-induced c-fos and c-jun gene expression.	Tetradecanoylphorbol Acetate	137-140	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	149-154
1814434-11	1991	Staurosporine, a nonspecific inhibitor of PKC, partially blocked TPA-induced adherence and growth inhibition and concomitantly prevented TPA-induced c-fos and c-jun gene expression.	Tetradecanoylphorbol Acetate	137-140	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	159-164
1915667-3	1991	In this paper we show that epidermal growth factor (EGF)- and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced expression of the c-fos and c-jun protooncogenes is decreased in microgravity, while no effect of gravity changes was observed on A23187- and forskolin-induced expression of these genes.	Tetradecanoylphorbol Acetate	62-99	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-137
1915667-3	1991	In this paper we show that epidermal growth factor (EGF)- and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced expression of the c-fos and c-jun protooncogenes is decreased in microgravity, while no effect of gravity changes was observed on A23187- and forskolin-induced expression of these genes.	Tetradecanoylphorbol Acetate	62-99	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	142-147
1915667-3	1991	In this paper we show that epidermal growth factor (EGF)- and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced expression of the c-fos and c-jun protooncogenes is decreased in microgravity, while no effect of gravity changes was observed on A23187- and forskolin-induced expression of these genes.	Tetradecanoylphorbol Acetate	101-104	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-137
11299067-9	2001	The MOF score and blood TM levels were positively correlated with DIC score, thrombin-AT-III complex and tPA-PAI-1 complex, and negatively correlated with blood platelet count.	Tetradecanoylphorbol Acetate	105-108	serpin family E member 1	Homo sapiens	109-114
1915667-3	1991	In this paper we show that epidermal growth factor (EGF)- and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced expression of the c-fos and c-jun protooncogenes is decreased in microgravity, while no effect of gravity changes was observed on A23187- and forskolin-induced expression of these genes.	Tetradecanoylphorbol Acetate	101-104	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	142-147
1696147-2	1990	The cells readily adhered on fibronectin, but TPA was needed for adherence on vitronectin and for the spreading of the cells on both substrata.	Tetradecanoylphorbol Acetate	46-49	vitronectin	Homo sapiens	78-89
1696147-10	1990	Thus, the results suggest that TPA would activate several integrin receptors in HEL cells and also stimulate the secretion of thrombospondin, which might be used as an adhesion ligand for the integrin vitronectin receptor alpha v/beta 3 complex.	Tetradecanoylphorbol Acetate	31-34	vitronectin	Homo sapiens	201-212
11299067-12	2001	Among the parameters indicating coagulopathy, tPA-PAI-1 complex, which is considered to originate from ECA, seemed to be a sensitive parameter of MODS and ECI, and might be a predictive marker of MODS.	Tetradecanoylphorbol Acetate	46-49	serpin family E member 1	Homo sapiens	50-55
1655978-8	1991	TPA induced c-fos and junB mRNAs transiently and preceding NGF mRNA induction but c-jun mRNA remained undetectable.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	12-17
12369726-4	2001	The induced activities of p21ras and its associated down-stream regulatory enzyme MAP-kinase following TPA stimulation were also comparable in the IR and WC patients.	Tetradecanoylphorbol Acetate	103-106	HRas proto-oncogene, GTPase	Homo sapiens	26-32
1656468-4	1991	Furthermore, when transfected CV-1 cells were treated with phorbol 12-myristate 13-acetate, a PKC activator, phosphorylation of wild-type hVDR was enhanced, whereas that of the Ser-51 mutant hVDR was unaffected.	Tetradecanoylphorbol Acetate	59-90	vitamin D receptor	Homo sapiens	138-142
1656468-4	1991	Furthermore, when transfected CV-1 cells were treated with phorbol 12-myristate 13-acetate, a PKC activator, phosphorylation of wild-type hVDR was enhanced, whereas that of the Ser-51 mutant hVDR was unaffected.	Tetradecanoylphorbol Acetate	59-90	vitamin D receptor	Homo sapiens	191-195
2164911-7	1990	Since ET-1 action involves activation of protein kinase-C (PKC), we studied the effect of a phorbol ester (PMA) on the down-regulation of ET-1 receptors.	Tetradecanoylphorbol Acetate	107-110	endothelin 1	Bos taurus	138-142
11527153-3	2001	Differentiation of MEG-01 cells with phorbol myristate acetate (PMA) was observed to result in a four-fold increase in both secreted and cell-associated PAI-1 antigen over a four day period.	Tetradecanoylphorbol Acetate	37-62	serpin family E member 1	Homo sapiens	153-158
1751404-0	1991	The role of jun and fos gene family members in 12-O-tetradecanoylphorbol-13-acetate induced hemopoietic differentiation.	Tetradecanoylphorbol Acetate	47-83	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-23
1751404-2	1991	In this study, we demonstrate that the expression of jun and fos gene family members is induced with variable kinetics during 12-O-tetradecanoylphorbol-13-acetate induced differentiation, with c-jun expression best paralleling differentiation.	Tetradecanoylphorbol Acetate	126-162	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	61-64
1913657-0	1991	Prostratin, a nonpromoting phorbol ester, inhibits induction by phorbol 12-myristate 13-acetate of ornithine decarboxylase, edema, and hyperplasia in CD-1 mouse skin.	Tetradecanoylphorbol Acetate	64-95	ornithine decarboxylase, structural 1	Mus musculus	99-122
11527153-3	2001	Differentiation of MEG-01 cells with phorbol myristate acetate (PMA) was observed to result in a four-fold increase in both secreted and cell-associated PAI-1 antigen over a four day period.	Tetradecanoylphorbol Acetate	64-67	serpin family E member 1	Homo sapiens	153-158
1680698-3	1991	ICAM-1 could be up-regulated only on the less differentiated cell lines HT29 and T84 by phorbol 12-myristate 13-acetate and by the cytokines interferon-gamma (IFN-gamma) and interleukin (IL) 1 beta.	Tetradecanoylphorbol Acetate	88-119	intercellular adhesion molecule 1	Homo sapiens	0-6
11169207-6	2001	Without pIgA, mimicking phospholipase-C activation by combining low concentrations of phorbol myristate acetate with ionomycin, or high concentrations of ionomycin alone, stimulates the rabbit, but not the human, pIgR transcytosis.	Tetradecanoylphorbol Acetate	86-111	polymeric immunoglobulin receptor	Homo sapiens	213-217
1939341-6	1991	Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.	Tetradecanoylphorbol Acetate	139-142	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	67-72
1939341-6	1991	Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.	Tetradecanoylphorbol Acetate	139-142	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	165-170
1939341-6	1991	Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.	Tetradecanoylphorbol Acetate	139-142	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	175-180
11152962-3	2000	In agreement with our previous finding that p90(rsk1) is essential for TPA-induced activation of NF-kappaB in Adenovirus 5E1-transformed Baby Rat Kidney cells, we now report that the MEK/ERK/p90(rsk1) inhibitor U0126 efficiently blocks TPA-induced IkappaBalpha processing in these cells.	Tetradecanoylphorbol Acetate	71-74	ribosomal protein S6 kinase A1	Rattus norvegicus	44-52
1939341-6	1991	Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.	Tetradecanoylphorbol Acetate	139-142	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-62
1939341-6	1991	Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.	Tetradecanoylphorbol Acetate	139-142	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	67-72
1939341-6	1991	Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.	Tetradecanoylphorbol Acetate	139-142	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	165-170
1939341-6	1991	Nuclear run-on assays demonstrate that: (1) induction of c-jun and c-fos expression by TPA is regulated by transcriptional mechanisms, (2) TPA-induced expression of c-jun and c-fos does not require protein synthesis, and (3) TPA-induced expression of both genes is inhibited at the transcriptional level by dexamethasone.	Tetradecanoylphorbol Acetate	139-142	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	175-180
1939341-8	1991	Increases in CAT activity during transient expression of these constructs in TPA-treated U-937 cells could be assigned to the region (-97 to -20) of the promoter that contains the AP-1 binding site.	Tetradecanoylphorbol Acetate	77-80	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	180-184
1939341-10	1991	These findings suggest that dexamethasone down-regulates TPA-induced transcription of the c-jun gene during monocytic differentiation by inhibiting activation of the AP-1 site.	Tetradecanoylphorbol Acetate	57-60	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-95
11152962-3	2000	In agreement with our previous finding that p90(rsk1) is essential for TPA-induced activation of NF-kappaB in Adenovirus 5E1-transformed Baby Rat Kidney cells, we now report that the MEK/ERK/p90(rsk1) inhibitor U0126 efficiently blocks TPA-induced IkappaBalpha processing in these cells.	Tetradecanoylphorbol Acetate	71-74	ribosomal protein S6 kinase A1	Rattus norvegicus	191-199
1939341-10	1991	These findings suggest that dexamethasone down-regulates TPA-induced transcription of the c-jun gene during monocytic differentiation by inhibiting activation of the AP-1 site.	Tetradecanoylphorbol Acetate	57-60	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	166-170
11152962-3	2000	In agreement with our previous finding that p90(rsk1) is essential for TPA-induced activation of NF-kappaB in Adenovirus 5E1-transformed Baby Rat Kidney cells, we now report that the MEK/ERK/p90(rsk1) inhibitor U0126 efficiently blocks TPA-induced IkappaBalpha processing in these cells.	Tetradecanoylphorbol Acetate	71-74	NFKB inhibitor alpha	Rattus norvegicus	248-260
11152962-3	2000	In agreement with our previous finding that p90(rsk1) is essential for TPA-induced activation of NF-kappaB in Adenovirus 5E1-transformed Baby Rat Kidney cells, we now report that the MEK/ERK/p90(rsk1) inhibitor U0126 efficiently blocks TPA-induced IkappaBalpha processing in these cells.	Tetradecanoylphorbol Acetate	236-239	ribosomal protein S6 kinase A1	Rattus norvegicus	44-52
1662987-6	1991	An analysis of defined elements in different promoters suggests that serine/threonine phosphoprotein phosphatases are involved in the regulation of the c-jun and the collagenase 12-O-tetradecanoyl phorbol-13-acetate (TPA) response element (TRE) as well as the c-fos serum response element (SRE).	Tetradecanoylphorbol Acetate	217-220	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	152-157
11152962-3	2000	In agreement with our previous finding that p90(rsk1) is essential for TPA-induced activation of NF-kappaB in Adenovirus 5E1-transformed Baby Rat Kidney cells, we now report that the MEK/ERK/p90(rsk1) inhibitor U0126 efficiently blocks TPA-induced IkappaBalpha processing in these cells.	Tetradecanoylphorbol Acetate	236-239	ribosomal protein S6 kinase A1	Rattus norvegicus	191-199
1909938-3	1991	TPA induced a rapid, yet transient 500- to 1000-fold increase in ornithine decarboxylase (ODC) activity which resulted in a 2- to 8.4-fold elevation of putrescine in both singly or chronically TPA-treated mouse epidermis 4-6 h after its application.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	65-88
1909938-3	1991	TPA induced a rapid, yet transient 500- to 1000-fold increase in ornithine decarboxylase (ODC) activity which resulted in a 2- to 8.4-fold elevation of putrescine in both singly or chronically TPA-treated mouse epidermis 4-6 h after its application.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	90-93
11125308-3	2000	Concanavalin A or phorbol myristate acetate/calcium ionophore/anti-CD3 stimulation of spleen cells from H2(b) congenic mice induced less IL-1, IL-2, IFN-gamma and MIF mRNA and/or protein than the equivalent cells from H2(d) mice.	Tetradecanoylphorbol Acetate	18-43	interleukin 2	Mus musculus	143-147
1909938-3	1991	TPA induced a rapid, yet transient 500- to 1000-fold increase in ornithine decarboxylase (ODC) activity which resulted in a 2- to 8.4-fold elevation of putrescine in both singly or chronically TPA-treated mouse epidermis 4-6 h after its application.	Tetradecanoylphorbol Acetate	193-196	ornithine decarboxylase, structural 1	Mus musculus	65-88
1909938-3	1991	TPA induced a rapid, yet transient 500- to 1000-fold increase in ornithine decarboxylase (ODC) activity which resulted in a 2- to 8.4-fold elevation of putrescine in both singly or chronically TPA-treated mouse epidermis 4-6 h after its application.	Tetradecanoylphorbol Acetate	193-196	ornithine decarboxylase, structural 1	Mus musculus	90-93
11090594-7	2000	Activity of AP-1-dependent luciferase reporter driven by 12-O-tetradecanoyl-phorbol-13-acetate-responsive element (TRE) was induced by cyclic strain, and this was attenuated by PD-98059, MEKK(K-M), JNK(K-R), and SB-203580.	Tetradecanoylphorbol Acetate	57-94	Jun proto-oncogene, AP-1 transcription factor subunit	Bos taurus	12-16
1861152-4	1991	Further, an increase in calcium/phospholipid-dependent kinase (PKC) activity resulting from the treatment of PC12 cells with NGF and TPA was observed concomitant with the increased phosphorylation of NF-M.	Tetradecanoylphorbol Acetate	133-136	protein kinase C, alpha	Rattus norvegicus	63-66
1861152-7	1991	These data suggest that NGF with or without TPA stimulates NF-M phosphorylation as a result of a complex series of events which include PKC-independent and PKC-dependent pathways.	Tetradecanoylphorbol Acetate	44-47	protein kinase C, alpha	Rattus norvegicus	136-139
1861152-7	1991	These data suggest that NGF with or without TPA stimulates NF-M phosphorylation as a result of a complex series of events which include PKC-independent and PKC-dependent pathways.	Tetradecanoylphorbol Acetate	44-47	protein kinase C, alpha	Rattus norvegicus	156-159
10976111-3	2000	The effect of TPA was specifically abolished by the PKC inhibitor GF109203X and by dominant negative PKCtheta, PKCepsilon, and PKCalpha, suggesting that novel and conventional PKC isoforms mediate phorbol ester action.	Tetradecanoylphorbol Acetate	14-17	protein kinase C epsilon	Homo sapiens	111-121
1654511-2	1991	In the presence of appropriate external solutions and drugs to reduce contamination from sodium, calcium, and potassium ion currents, application of phorbol 12-myristate 13-acetate or phorbol 12,13-dibutyrate, to stimulate PKC, activated a time-independent background current.	Tetradecanoylphorbol Acetate	149-180	protein kinase C, gamma	Rattus norvegicus	223-226
11126343-7	2000	In multiple linear regression analysis, triglycerides and PAI-1-Ag explained significant independent proportions of the variance of tPA-Ag.	Tetradecanoylphorbol Acetate	132-135	serpin family E member 1	Homo sapiens	58-63
1907991-10	1991	Anti-Ly6A/E, by itself, does not stimulate an increase in [3H]thymidine incorporation by IFN-gamma-treated resting B cells, but induces a striking increase in the presence of PMA.	Tetradecanoylphorbol Acetate	175-178	lymphocyte antigen 6 complex, locus A	Mus musculus	5-11
10931849-5	2000	TPA-induced differentiation of K562 cells causes rapid down-regulation of c-myc expression, due in part to an mRNA decay rate that is 4-fold faster compared with dividing cells.	Tetradecanoylphorbol Acetate	0-3	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	74-79
1653025-5	1991	Treatment with TPA provoked a loss of activity of peaks 1b (PKC-alpha) and 1c, whereas peak 1a (PKC-beta) activity was not affected.	Tetradecanoylphorbol Acetate	15-18	protein kinase C, alpha	Rattus norvegicus	60-77
1907719-5	1991	The mutant Jun lacks an activation domain and blocks stimulation of transcription by several oncoproteins, including Ras, v-Src, polyoma middle T, c-Jun and c-Fos, as well as by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	198-234	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	147-152
1907719-5	1991	The mutant Jun lacks an activation domain and blocks stimulation of transcription by several oncoproteins, including Ras, v-Src, polyoma middle T, c-Jun and c-Fos, as well as by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	236-239	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	147-152
1907719-5	1991	The mutant Jun lacks an activation domain and blocks stimulation of transcription by several oncoproteins, including Ras, v-Src, polyoma middle T, c-Jun and c-Fos, as well as by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	236-239	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-162
10931849-6	2000	A cell-free mRNA decay system reconstitutes TPA-induced destabilization of c-myc mRNA, but it requires at least two components for reconstitution.	Tetradecanoylphorbol Acetate	44-47	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	75-80
11040403-3	2000	In contrast, although neutrophil stimulation with tumor necrosis factor (TNF)-alpha, granulocyte macrophage-colony stimulating factor (GM-CSF), fMLP or phorbol myristate acetate (PMA) gave rise to a massive and prolonged FN-primed O(2)(-) release, a significant impairment of oxidative response occurred in the aged group as a result of GM-CSF or fMLP cell challenge.	Tetradecanoylphorbol Acetate	152-177	colony stimulating factor 2	Homo sapiens	337-343
1677641-1	1991	We have previously reported that K562/ADM, a typical P-glycoprotein-mediated multi-drug-resistant cell line, is cross-resistant to the growth-inhibitory effect of 12-O-tetradecanoylphorbol 13-acetate (TPA) and non-TPA type tumor promoters.	Tetradecanoylphorbol Acetate	163-199	adrenomedullin	Homo sapiens	33-41
1677641-1	1991	We have previously reported that K562/ADM, a typical P-glycoprotein-mediated multi-drug-resistant cell line, is cross-resistant to the growth-inhibitory effect of 12-O-tetradecanoylphorbol 13-acetate (TPA) and non-TPA type tumor promoters.	Tetradecanoylphorbol Acetate	201-204	adrenomedullin	Homo sapiens	33-41
1677641-1	1991	We have previously reported that K562/ADM, a typical P-glycoprotein-mediated multi-drug-resistant cell line, is cross-resistant to the growth-inhibitory effect of 12-O-tetradecanoylphorbol 13-acetate (TPA) and non-TPA type tumor promoters.	Tetradecanoylphorbol Acetate	214-217	adrenomedullin	Homo sapiens	33-41
1677641-5	1991	K562/TPA showed cross-resistance to etoposide, teniposide, adriamycin (ADM), vincristine, vindesine and 3-[(4-amino-2-methyl-5-pyrimidinyl)] methyl-1-(2-chloroethyl)-1-nitrosourea, but showed collateral sensitivity to cisplatin.	Tetradecanoylphorbol Acetate	5-8	adrenomedullin	Homo sapiens	71-74
11023507-2	2000	Expression of GPVI is increased in the megakaryoblastic cell lines HEL and CMK on differentiation with the phorbol ester phorbol 12-myristate 13-acetate (PMA), along with the Fc receptor gamma-chain (FcR gamma-chain).	Tetradecanoylphorbol Acetate	121-152	glycoprotein VI platelet	Homo sapiens	14-18
1677641-8	1991	Accumulation of ADM by K562/TPA was no lower than that of K562 although that of K562/ADM was 5-fold lower than K562.	Tetradecanoylphorbol Acetate	28-31	adrenomedullin	Homo sapiens	16-19
1677641-10	1991	The fluorescence of ADM was located in the nucleus of K562 and mainly in the cytoplasm of K562/TPA and K562/ADM.	Tetradecanoylphorbol Acetate	95-98	adrenomedullin	Homo sapiens	20-23
1677641-11	1991	The distribution of ADM in K562/TPA, however, was different from that in K562/ADM.	Tetradecanoylphorbol Acetate	32-35	adrenomedullin	Homo sapiens	20-23
1859360-4	1991	IL 1 and phorbol 12-myristate 13-acetate (PMA) also induced an increase in the constitutive hsp70 mRNA species, but without affecting the expression of the inducible hsp70 gene.	Tetradecanoylphorbol Acetate	9-40	heat shock protein family A (Hsp70) member 4	Homo sapiens	92-97
1859360-4	1991	IL 1 and phorbol 12-myristate 13-acetate (PMA) also induced an increase in the constitutive hsp70 mRNA species, but without affecting the expression of the inducible hsp70 gene.	Tetradecanoylphorbol Acetate	9-40	heat shock protein family A (Hsp70) member 4	Homo sapiens	166-171
11023507-2	2000	Expression of GPVI is increased in the megakaryoblastic cell lines HEL and CMK on differentiation with the phorbol ester phorbol 12-myristate 13-acetate (PMA), along with the Fc receptor gamma-chain (FcR gamma-chain).	Tetradecanoylphorbol Acetate	154-157	glycoprotein VI platelet	Homo sapiens	14-18
10918063-1	2000	The transcriptional induction of SPRR1B by phorbol 12-myristate 13-acetate (PMA) is mainly mediated by the first -152-base pair 5"-flanking region containing two functional AP-1 sites.	Tetradecanoylphorbol Acetate	43-74	small proline rich protein 1B	Homo sapiens	33-39
1859360-4	1991	IL 1 and phorbol 12-myristate 13-acetate (PMA) also induced an increase in the constitutive hsp70 mRNA species, but without affecting the expression of the inducible hsp70 gene.	Tetradecanoylphorbol Acetate	42-45	heat shock protein family A (Hsp70) member 4	Homo sapiens	92-97
10918063-1	2000	The transcriptional induction of SPRR1B by phorbol 12-myristate 13-acetate (PMA) is mainly mediated by the first -152-base pair 5"-flanking region containing two functional AP-1 sites.	Tetradecanoylphorbol Acetate	76-79	small proline rich protein 1B	Homo sapiens	33-39
2061303-2	1991	We have cloned ETR101 cDNA whose mRNA was induced immediate early (30 min) and transiently by TPA.	Tetradecanoylphorbol Acetate	94-97	immediate early response 2	Homo sapiens	15-21
10918063-3	2000	PKC inhibitor ablated PMA-stimulated expression of endogenous SPRR1B and reporter gene expression driven by SPRR1B promoter.	Tetradecanoylphorbol Acetate	22-25	small proline rich protein 1B	Homo sapiens	62-68
2061303-5	1991	ETR101 mRNA is induced by TPA in a wide variety of leukemia cells including myeloid, T-lymphoid, and B-lymphoid lineages.	Tetradecanoylphorbol Acetate	26-29	immediate early response 2	Homo sapiens	0-6
10918063-3	2000	PKC inhibitor ablated PMA-stimulated expression of endogenous SPRR1B and reporter gene expression driven by SPRR1B promoter.	Tetradecanoylphorbol Acetate	22-25	small proline rich protein 1B	Homo sapiens	108-114
2162765-3	1990	On the collagenase promoter, PEA3 acts synergistically with AP-1 to achieve maximum levels of transcription activation by 12-O-tetradecanoylphorbol-13-acetate (TPA), and non-nuclear oncoproteins, thereby defining a TPA- and oncogene-responsive unit (TORU).	Tetradecanoylphorbol Acetate	122-158	ETS variant transcription factor 4	Homo sapiens	29-33
10918063-13	2000	dn-c-Jun mutants abolished PMA-stimulated expression supporting an important role for AP-1 proteins in SPRR1B expression.	Tetradecanoylphorbol Acetate	27-30	small proline rich protein 1B	Homo sapiens	103-109
2162765-3	1990	On the collagenase promoter, PEA3 acts synergistically with AP-1 to achieve maximum levels of transcription activation by 12-O-tetradecanoylphorbol-13-acetate (TPA), and non-nuclear oncoproteins, thereby defining a TPA- and oncogene-responsive unit (TORU).	Tetradecanoylphorbol Acetate	160-163	ETS variant transcription factor 4	Homo sapiens	29-33
10918063-14	2000	Together, these results suggest that a PKCdelta/Ras/MEKK1/MKK1-dependent/AP-1 pathway regulates the PMA-inducible expression of the SPRR1B in tracheobronchial epithelial cells.	Tetradecanoylphorbol Acetate	100-103	mitogen-activated protein kinase kinase 1	Homo sapiens	58-62
2162765-3	1990	On the collagenase promoter, PEA3 acts synergistically with AP-1 to achieve maximum levels of transcription activation by 12-O-tetradecanoylphorbol-13-acetate (TPA), and non-nuclear oncoproteins, thereby defining a TPA- and oncogene-responsive unit (TORU).	Tetradecanoylphorbol Acetate	215-218	ETS variant transcription factor 4	Homo sapiens	29-33
1858892-9	1991	By contrast, the protein kinase C activator phorbol myristate acetate only enhanced preproET-1 mRNA expression at 30 min and suppressed expression thereafter.	Tetradecanoylphorbol Acetate	44-69	endothelin 1	Bos taurus	84-94
10918063-14	2000	Together, these results suggest that a PKCdelta/Ras/MEKK1/MKK1-dependent/AP-1 pathway regulates the PMA-inducible expression of the SPRR1B in tracheobronchial epithelial cells.	Tetradecanoylphorbol Acetate	100-103	small proline rich protein 1B	Homo sapiens	132-138
2361470-1	1990	Activators of protein kinase C, such as phorbol myristate acetate (PMA) and the synthetic diacylglycerol dioctanoylglycerol (diC8), either stimulate or inhibit PTH release depending on the extracellular Ca2+ concentration.	Tetradecanoylphorbol Acetate	40-65	parathyroid hormone	Bos taurus	160-163
11012779-7	2000	Enhancement of cytokine production was also observed in GM-CSF-treated macrophages after stimulation by phorbol 12-myristate 13-acetate (PMA), thus indicating that GM-CSF affects both CD14-dependent and -independent cytokine production.	Tetradecanoylphorbol Acetate	104-135	colony stimulating factor 2	Homo sapiens	56-62
2361470-1	1990	Activators of protein kinase C, such as phorbol myristate acetate (PMA) and the synthetic diacylglycerol dioctanoylglycerol (diC8), either stimulate or inhibit PTH release depending on the extracellular Ca2+ concentration.	Tetradecanoylphorbol Acetate	67-70	parathyroid hormone	Bos taurus	160-163
2361470-12	1990	With respect to secretion, either of the protein kinase C agonists (i.e. PMA or diC8) or the Ca2+ ionophore ionomycin inhibited PTH release at 0.5 mM Ca2+.	Tetradecanoylphorbol Acetate	73-76	parathyroid hormone	Bos taurus	128-131
1648385-12	1991	The induction of t-PA mRNA by PMA was dependent on protein synthesis and was preceded by a strong transient increase in c-jun and c-fos mRNA levels; the induction of c-fos but not of c-jun was potentiated by forskolin.	Tetradecanoylphorbol Acetate	30-33	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-125
1648385-12	1991	The induction of t-PA mRNA by PMA was dependent on protein synthesis and was preceded by a strong transient increase in c-jun and c-fos mRNA levels; the induction of c-fos but not of c-jun was potentiated by forskolin.	Tetradecanoylphorbol Acetate	30-33	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-135
11012779-7	2000	Enhancement of cytokine production was also observed in GM-CSF-treated macrophages after stimulation by phorbol 12-myristate 13-acetate (PMA), thus indicating that GM-CSF affects both CD14-dependent and -independent cytokine production.	Tetradecanoylphorbol Acetate	104-135	colony stimulating factor 2	Homo sapiens	164-170
1648385-12	1991	The induction of t-PA mRNA by PMA was dependent on protein synthesis and was preceded by a strong transient increase in c-jun and c-fos mRNA levels; the induction of c-fos but not of c-jun was potentiated by forskolin.	Tetradecanoylphorbol Acetate	30-33	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	166-171
11012779-7	2000	Enhancement of cytokine production was also observed in GM-CSF-treated macrophages after stimulation by phorbol 12-myristate 13-acetate (PMA), thus indicating that GM-CSF affects both CD14-dependent and -independent cytokine production.	Tetradecanoylphorbol Acetate	137-140	colony stimulating factor 2	Homo sapiens	56-62
2119527-5	1990	Phorbol myristate acetate also induced release of t-PA and vWF, though with a different time course; DDAVP was inactive.	Tetradecanoylphorbol Acetate	0-25	von Willebrand factor	Rattus norvegicus	59-62
1715317-2	1991	FK-506 and CsA were also potent inhibitors of A23187/PMA-stimulated IL-2 production by Jurkat and HuT-78 cells but had no effect on the response of mouse CTLL cells to IL-2.	Tetradecanoylphorbol Acetate	53-56	chorionic somatomammotropin hormone 1	Homo sapiens	0-14
11012779-7	2000	Enhancement of cytokine production was also observed in GM-CSF-treated macrophages after stimulation by phorbol 12-myristate 13-acetate (PMA), thus indicating that GM-CSF affects both CD14-dependent and -independent cytokine production.	Tetradecanoylphorbol Acetate	137-140	colony stimulating factor 2	Homo sapiens	164-170
1723066-5	1991	By itself, soluble mAb AC7 was not mitogenic for T cells but enhanced T cell proliferation that resulted from treatment with phorbol myristic acetate (PMA) in the presence of accessory cells.	Tetradecanoylphorbol Acetate	151-154	adenylate cyclase 7	Homo sapiens	23-26
11074603-5	2000	These results are in contrast to our previous observation that, HK1.ras, HK1.fos, and HK1.TGFalpha transgenic mice with the p53(-/-) genotype display an unexpected delay in both spontaneous and TPA-promoted papilloma formation compared with mice with p53(+/+) and p53(+/-) genotypes.	Tetradecanoylphorbol Acetate	194-197	transformation related protein 53, pseudogene	Mus musculus	124-127
1861870-1	1991	We previously reported the sequence of a cDNA, TIS11, cloned from TPA-treated Swiss 3T3 cells.	Tetradecanoylphorbol Acetate	66-69	zinc finger protein 36	Mus musculus	47-52
2231740-2	1990	In a Na(+)-and K(+)-free external solution, the delayed rectifier K+ current (IK) was increased by the activator of protein kinase C (PKC), 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	140-176	Prkca	Cavia porcellus	116-132
2231740-2	1990	In a Na(+)-and K(+)-free external solution, the delayed rectifier K+ current (IK) was increased by the activator of protein kinase C (PKC), 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	140-176	Prkca	Cavia porcellus	134-137
1656202-6	1991	After phorbol myristate acetate (PMA)-cell stimulation, cytochrome b was mobilized to fractions showing respiratory burst activity and enriched in 5"-nucleotidase activity.	Tetradecanoylphorbol Acetate	6-31	mitochondrially encoded cytochrome b	Homo sapiens	56-68
2231740-2	1990	In a Na(+)-and K(+)-free external solution, the delayed rectifier K+ current (IK) was increased by the activator of protein kinase C (PKC), 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	178-181	Prkca	Cavia porcellus	116-132
11028541-11	2000	Conversely, HTS attenuated PAF priming of PMA-mediated O2- production.	Tetradecanoylphorbol Acetate	42-45	PCNA clamp associated factor	Homo sapiens	27-30
2231740-2	1990	In a Na(+)-and K(+)-free external solution, the delayed rectifier K+ current (IK) was increased by the activator of protein kinase C (PKC), 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	178-181	Prkca	Cavia porcellus	134-137
2231740-4	1990	The increase in IK produced by 1 nM TPA was abolished by the inhibitor of PKC, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7, 10 microM).	Tetradecanoylphorbol Acetate	36-39	Prkca	Cavia porcellus	74-77
2231740-6	1990	PKC purified from bovine brain remarkably increased IK (151 +/- 101%, n = 5) in the presence of 1 nM TPA when it was internally applied using the cell dialysis method.	Tetradecanoylphorbol Acetate	101-104	Prkca	Cavia porcellus	0-3
2231740-7	1990	The concentration-response curve of IK for the intracellular concentration of Ca2+ was shifted to the left by 1 nM TPA, suggesting a Ca2(+)-dependent action of PKC and/or altered Ca2(+)-sensitivity of IK channels by phosphorylation.	Tetradecanoylphorbol Acetate	115-118	Prkca	Cavia porcellus	160-163
1656202-6	1991	After phorbol myristate acetate (PMA)-cell stimulation, cytochrome b was mobilized to fractions showing respiratory burst activity and enriched in 5"-nucleotidase activity.	Tetradecanoylphorbol Acetate	33-36	mitochondrially encoded cytochrome b	Homo sapiens	56-68
1904863-5	1991	Anoxia induces a further increase in total HIV-1 RNA in ACH.2 cells prestimulated to produce virus by phorbol 12-myristate 13-acetate and in H9 T cells acutely infected with HIV-1-IIIB.	Tetradecanoylphorbol Acetate	102-133	acyl-CoA thioesterase 1	Homo sapiens	56-61
2050666-10	1991	A 10-min exposure of the endothelial cells to low doses of phorbol 12-myristate 13-acetate was found to reduce Na-K-Cl cotransport whether in the presence or absence of angiotensin II, vasopressin, or bradykinin.	Tetradecanoylphorbol Acetate	59-90	kininogen 1	Bos taurus	201-211
10922477-2	2000	In this study, we demonstrate that PMA inhibits STAT activation by IL-6 and the related cytokine leukemia inhibitory factor (LIF) but not by oncostatin M (OSM).	Tetradecanoylphorbol Acetate	35-38	LIF interleukin 6 family cytokine	Homo sapiens	125-128
10861271-8	2000	Basal migration and the motogenic effects of butyrate, epidermal growth factor, and phorbol-12-myristate-13-acetate were suppressed by the u-PAR antisense oligonucleotide (40-60%) but were at best minimally affected following inhibition of u-PA expression and binding.	Tetradecanoylphorbol Acetate	84-115	plasminogen activator, urokinase receptor	Homo sapiens	139-144
2059213-5	1991	12-0-Tetradecanoylphorbol-13-acetate (TPA) also induced the synthesis of 15-PGDH but inhibited the enzyme activity.	Tetradecanoylphorbol Acetate	38-41	carbonyl reductase 1	Homo sapiens	73-80
2059213-6	1991	It appears that TPA caused a time dependent inactivation of 15-PGDH by a protein kinase C mediated mechanism.	Tetradecanoylphorbol Acetate	16-19	carbonyl reductase 1	Homo sapiens	60-67
2377740-4	1990	The phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate (TPA) and the synthetic diacylglycerol analogue 1-oleoyl-2-acetyl-sn-glycerol (OAG) are receptor-independent activators of the protein kinase C. Both TPA (10(-6) M) and OAG (10(-5) M) stimulated gastrin release to 214.0 +/- 29.3% and 198.2 +/- 20.8% of basal, respectively.	Tetradecanoylphorbol Acetate	18-55	gastrin	Rattus norvegicus	251-258
2163336-3	1990	The PK-C activator 12-O-tetradecanoylphorbol 13-acetate (TPA, 100 nmol/l) suppressed the FSH effect on cAMP output by 50-70% (p less than 0.01) in stages II-VI, but had no effect in stages VII-VIII.	Tetradecanoylphorbol Acetate	19-55	protein kinase C, gamma	Rattus norvegicus	4-8
2163336-3	1990	The PK-C activator 12-O-tetradecanoylphorbol 13-acetate (TPA, 100 nmol/l) suppressed the FSH effect on cAMP output by 50-70% (p less than 0.01) in stages II-VI, but had no effect in stages VII-VIII.	Tetradecanoylphorbol Acetate	57-60	protein kinase C, gamma	Rattus norvegicus	4-8
1889509-7	1991	Addition of PMA at a concentration of 100 ng/ml into the medium caused an increase in the cellular and medium levels of hCG alpha, hCG beta and hCG shortly (3h) after the exposure to PMA.	Tetradecanoylphorbol Acetate	12-15	chorionic gonadotropin subunit beta 3	Homo sapiens	131-139
10884289-5	2000	TPA treatment of infected adipocytes increased luciferase activity, consistent with previous studies indicating that the KLBP/FABP5 gene is up-regulated by phorbol esters.	Tetradecanoylphorbol Acetate	0-3	fatty acid binding protein 5, epidermal	Mus musculus	121-125
1889509-7	1991	Addition of PMA at a concentration of 100 ng/ml into the medium caused an increase in the cellular and medium levels of hCG alpha, hCG beta and hCG shortly (3h) after the exposure to PMA.	Tetradecanoylphorbol Acetate	183-186	chorionic gonadotropin subunit beta 3	Homo sapiens	131-139
10871841-0	2000	Annexin V inhibits the 12-O-tetradecanoylphorbol-13-acetate-induced activation of Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of Shc in MCF-7 cells.	Tetradecanoylphorbol Acetate	23-59	annexin A5	Homo sapiens	0-9
1904283-6	1991	Both TPA and 1,25(OH)2D3, which induce HL-60 cells to differentiate to macrophages, resulted in marked increases in c-jun mRNA; while RA and DMSO, which induce HL-60 cells to differentiate to granulocytes, did not greatly alter c-jun mRNA expression.	Tetradecanoylphorbol Acetate	5-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-121
2109010-0	1990	Phorbol myristate acetate-induced down-modulation of CD4 is dependent on calmodulin and intracellular calcium.	Tetradecanoylphorbol Acetate	0-25	calmodulin 2	Mus musculus	73-83
10871841-5	2000	Morphological changes induced by TPA were reduced by annexin V overexpression as well as by the pan-PKC inhibitor, bisindolylmaleimide I, and by the mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) inhibitor, PD98059.	Tetradecanoylphorbol Acetate	33-36	annexin A5	Homo sapiens	53-62
2318854-4	1990	Like endogenous and exogenously expressed wild type PKC alpha, the mutant PKC alpha K----R is translocated from the cytosol to the particulate fraction when cells are treated with a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	197-233	protein kinase C, alpha	Rattus norvegicus	74-83
2318854-4	1990	Like endogenous and exogenously expressed wild type PKC alpha, the mutant PKC alpha K----R is translocated from the cytosol to the particulate fraction when cells are treated with a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	235-238	protein kinase C, alpha	Rattus norvegicus	74-83
1904283-6	1991	Both TPA and 1,25(OH)2D3, which induce HL-60 cells to differentiate to macrophages, resulted in marked increases in c-jun mRNA; while RA and DMSO, which induce HL-60 cells to differentiate to granulocytes, did not greatly alter c-jun mRNA expression.	Tetradecanoylphorbol Acetate	5-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	228-233
2040611-6	1991	In these four cell lines, serum and/or phorbol 12-myristate 13-acetate exerted a large stimulatory effect on MARCKS protein phosphorylation.	Tetradecanoylphorbol Acetate	39-70	myristoylated alanine rich protein kinase C substrate	Mus musculus	109-115
10871841-6	2000	TPA-induced MEK1/2 and Raf-1 phosphorylation were reduced in these cells.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase kinase 1	Homo sapiens	12-18
10871841-11	2000	TPA induced the expression of p21WAF/CIP1 to a greater extent in MCF-7 parent and control plasmid cells than in annexin V overexpressors.	Tetradecanoylphorbol Acetate	0-3	annexin A5	Homo sapiens	112-121
10820198-10	2000	We found that CHP100 cells constitutively express both CXCR4 and CCR5 receptors and that stimulation with phorbol 12-myristate 13-acetate down-regulates their expression, thus preventing gp120-induced cell death.	Tetradecanoylphorbol Acetate	106-137	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	187-192
2318854-5	1990	On the other hand, the mutant PKC alpha K----R is not degraded when cells are treated with TPA, making a clear contrast to wild type PKC alpha; i.e. the mutant is resistant to TPA-mediated down-regulation.	Tetradecanoylphorbol Acetate	91-94	protein kinase C, alpha	Rattus norvegicus	30-39
10788447-5	2000	Interestingly, cotreatment with PMA (400 nm) attenuated IGF-1-induced activation of Akt.	Tetradecanoylphorbol Acetate	32-35	insulin-like growth factor 1	Rattus norvegicus	56-61
2318854-5	1990	On the other hand, the mutant PKC alpha K----R is not degraded when cells are treated with TPA, making a clear contrast to wild type PKC alpha; i.e. the mutant is resistant to TPA-mediated down-regulation.	Tetradecanoylphorbol Acetate	176-179	protein kinase C, alpha	Rattus norvegicus	30-39
2318854-5	1990	On the other hand, the mutant PKC alpha K----R is not degraded when cells are treated with TPA, making a clear contrast to wild type PKC alpha; i.e. the mutant is resistant to TPA-mediated down-regulation.	Tetradecanoylphorbol Acetate	176-179	protein kinase C, alpha	Rattus norvegicus	133-142
2318854-7	1990	These results suggest a link between the kinase activity of PKC alpha and the sensitivity to TPA-mediated proteolytic degradation.	Tetradecanoylphorbol Acetate	93-96	protein kinase C, alpha	Rattus norvegicus	60-69
2032222-1	1991	Naturally occurring plant phenols with antimutagenic and anticarcinogenic activities were tested for their abilities to inhibit the ornithine decarboxylase (ODC) response linked to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	205-241	ornithine decarboxylase, structural 1	Mus musculus	132-155
2032222-1	1991	Naturally occurring plant phenols with antimutagenic and anticarcinogenic activities were tested for their abilities to inhibit the ornithine decarboxylase (ODC) response linked to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	205-241	ornithine decarboxylase, structural 1	Mus musculus	157-160
2032222-1	1991	Naturally occurring plant phenols with antimutagenic and anticarcinogenic activities were tested for their abilities to inhibit the ornithine decarboxylase (ODC) response linked to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	243-246	ornithine decarboxylase, structural 1	Mus musculus	157-160
10775151-6	2000	FAK was also activated by phorbol 12-myristate 13-acetate (2 microM, 5 min).	Tetradecanoylphorbol Acetate	26-57	protein tyrosine kinase 2	Rattus norvegicus	0-3
2032222-2	1991	Topical applications of tannic acid (TA) inhibit remarkably and in a dose-dependent manner TPA-induced ODC activity in mouse epidermis in vivo.	Tetradecanoylphorbol Acetate	91-94	ornithine decarboxylase, structural 1	Mus musculus	103-106
2032222-4	1991	The induction of epidermal ODC activity by 8.5 nmol of TPA is inhibited maximally when 20 mumol of TA are applied topically to the skin 20 min before the tumor promoter.	Tetradecanoylphorbol Acetate	55-58	ornithine decarboxylase, structural 1	Mus musculus	27-30
2032222-5	1991	Gallic acid and several of its derivatives inhibit the ODC response to TPA to a lesser degree than TA.	Tetradecanoylphorbol Acetate	71-74	ornithine decarboxylase, structural 1	Mus musculus	55-58
2032222-7	1991	TA also inhibits the ODC-inducing activities of several structurally different tumor promoters and the greater ODC responses produced by repeated TPA treatments.	Tetradecanoylphorbol Acetate	146-149	ornithine decarboxylase, structural 1	Mus musculus	111-114
2333947-7	1990	Temporally, the maximal stimulation of PKC translocation by mezerein, teleocidin A, and TPA preceded their ability to stimulate maximal 125I-ANG II-specific binding.	Tetradecanoylphorbol Acetate	88-91	protein kinase C, gamma	Rattus norvegicus	39-42
10767399-5	2000	The superoxide generation induced by PMA with timosaponins E1 and E2 was suppressed by staurosporine, an inhibitor of protein kinase C, but was not suppressed by genistein, an inhibitor of protein tyrosine kinase.	Tetradecanoylphorbol Acetate	37-40	small nucleolar RNA, H/ACA box 73A	Homo sapiens	59-68
2099192-5	1990	The effect of heparin on c-fos mRNA induction was selective for specific mitogens, as heparin inhibited c-fos mRNA induction in phorbol 12-myristate 13-acetate (TPA) stimulated but not epidermal growth factor (EGF) stimulated VSMC.	Tetradecanoylphorbol Acetate	128-159	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	25-30
2099192-5	1990	The effect of heparin on c-fos mRNA induction was selective for specific mitogens, as heparin inhibited c-fos mRNA induction in phorbol 12-myristate 13-acetate (TPA) stimulated but not epidermal growth factor (EGF) stimulated VSMC.	Tetradecanoylphorbol Acetate	128-159	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	104-109
2099192-5	1990	The effect of heparin on c-fos mRNA induction was selective for specific mitogens, as heparin inhibited c-fos mRNA induction in phorbol 12-myristate 13-acetate (TPA) stimulated but not epidermal growth factor (EGF) stimulated VSMC.	Tetradecanoylphorbol Acetate	161-164	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	25-30
1645255-4	1991	UMR-106 cells treated with protein kinase C (PK-C) activating phorbol ester, phorbol 12-myristate 13-acetate (PMA, 10(-6) M) for 6 h also induced desensitization manifested by a loss of rPTH-stimulated cAMP accumulation to 50% of that in the control cells.	Tetradecanoylphorbol Acetate	77-108	protein kinase C, gamma	Rattus norvegicus	27-43
1645255-4	1991	UMR-106 cells treated with protein kinase C (PK-C) activating phorbol ester, phorbol 12-myristate 13-acetate (PMA, 10(-6) M) for 6 h also induced desensitization manifested by a loss of rPTH-stimulated cAMP accumulation to 50% of that in the control cells.	Tetradecanoylphorbol Acetate	77-108	protein kinase C, gamma	Rattus norvegicus	45-49
1645255-4	1991	UMR-106 cells treated with protein kinase C (PK-C) activating phorbol ester, phorbol 12-myristate 13-acetate (PMA, 10(-6) M) for 6 h also induced desensitization manifested by a loss of rPTH-stimulated cAMP accumulation to 50% of that in the control cells.	Tetradecanoylphorbol Acetate	110-113	protein kinase C, gamma	Rattus norvegicus	27-43
1645255-4	1991	UMR-106 cells treated with protein kinase C (PK-C) activating phorbol ester, phorbol 12-myristate 13-acetate (PMA, 10(-6) M) for 6 h also induced desensitization manifested by a loss of rPTH-stimulated cAMP accumulation to 50% of that in the control cells.	Tetradecanoylphorbol Acetate	110-113	protein kinase C, gamma	Rattus norvegicus	45-49
1645255-6	1991	Fifty micromolar H-7 (PK-C inhibitor) significantly blocked both rPTH- and PMA-induced desensitization.	Tetradecanoylphorbol Acetate	75-78	protein kinase C, gamma	Rattus norvegicus	22-26
2099192-5	1990	The effect of heparin on c-fos mRNA induction was selective for specific mitogens, as heparin inhibited c-fos mRNA induction in phorbol 12-myristate 13-acetate (TPA) stimulated but not epidermal growth factor (EGF) stimulated VSMC.	Tetradecanoylphorbol Acetate	161-164	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	104-109
10842315-1	2000	The tumor promoter phorbol 13-myristate 12-acetate (PMA), the best characterized protein kinase C agonist, frequently regulates gene expression via activation of Fos/Jun (AP-1) complexes.	Tetradecanoylphorbol Acetate	52-55	FBJ osteosarcoma oncogene	Mus musculus	162-165
2044660-13	1991	After stimulation with phorbol 12-myristate 13-acetate (PMA), there is a de novo protein synthesis-dependent increase in the level of CD44 transcripts.	Tetradecanoylphorbol Acetate	23-54	CD44 antigen	Mus musculus	134-138
2044660-13	1991	After stimulation with phorbol 12-myristate 13-acetate (PMA), there is a de novo protein synthesis-dependent increase in the level of CD44 transcripts.	Tetradecanoylphorbol Acetate	56-59	CD44 antigen	Mus musculus	134-138
10781803-0	2000	MAPK-dependent expression of p21(WAF) and p27(kip1) in PMA-induced differentiation of HL60 cells.	Tetradecanoylphorbol Acetate	55-58	cyclin dependent kinase inhibitor 1B	Homo sapiens	46-50
2110105-11	1990	Northern blotting showed that the transcription of the BPP gene was apparently induced by 12-O-tetradecanoylphorbol-13-acetate (phorbol derivative) in HeLa cells.	Tetradecanoylphorbol Acetate	90-126	sushi repeat containing protein X-linked 2	Homo sapiens	55-58
1711208-7	1991	Thus, the DAF gene promoter (i) exhibits sequences resembling both conventional and unconventional transcriptional control elements, (ii) possesses a region with negative regulatory activity, and (iii) responds to PMA and cAMP induction presumably via PRE- and CRE-like enhancer elements.	Tetradecanoylphorbol Acetate	214-217	CD55 molecule (Cromer blood group)	Homo sapiens	10-13
10781803-5	2000	PMA also induces the expression of the cyclin-dependent kinase inhibitors p21(WAF) and p27(kip1), which is modulated by the use of an inhibitor of the ERK cascade.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase inhibitor 1B	Homo sapiens	91-95
10797562-2	2000	Osteopontin (OPN) is a secreted, adhesive protein that is highly expressed in JB6 cells with TPA treatment, and its expression persists for at least 4 days, which is the time required for subsequent expression of transformed phenotype.	Tetradecanoylphorbol Acetate	93-96	secreted phosphoprotein 1	Homo sapiens	0-11
1851743-7	1991	Similar to its effect on the induction of AP1 by okadaic acid, PMA inhibits the induction of c-jun mRNA by okadaic acid.	Tetradecanoylphorbol Acetate	63-66	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-45
1851743-7	1991	Similar to its effect on the induction of AP1 by okadaic acid, PMA inhibits the induction of c-jun mRNA by okadaic acid.	Tetradecanoylphorbol Acetate	63-66	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-98
2178703-4	1990	Peritoneal neutrophils isolated from mice treated with rGM-CSF exhibited primed superoxide generation (O2-) after in vitro stimulation with suboptimal concentrations of phorbol myristate acetate (PMA), as compared with control mice (treated with diluent).	Tetradecanoylphorbol Acetate	169-194	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	59-62
2178703-4	1990	Peritoneal neutrophils isolated from mice treated with rGM-CSF exhibited primed superoxide generation (O2-) after in vitro stimulation with suboptimal concentrations of phorbol myristate acetate (PMA), as compared with control mice (treated with diluent).	Tetradecanoylphorbol Acetate	196-199	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	59-62
10797562-2	2000	Osteopontin (OPN) is a secreted, adhesive protein that is highly expressed in JB6 cells with TPA treatment, and its expression persists for at least 4 days, which is the time required for subsequent expression of transformed phenotype.	Tetradecanoylphorbol Acetate	93-96	secreted phosphoprotein 1	Homo sapiens	13-16
10797562-6	2000	TPA-treated JB6 cells had significantly (P &lt; 0.05) increased adherence to OPN compared with dimethylsulfoxide-treated control cells.	Tetradecanoylphorbol Acetate	0-3	secreted phosphoprotein 1	Homo sapiens	77-80
2109710-2	1990	A relatively selective PKC inhibitor, staurosporine, inhibited both GnRH- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced luteinizing hormone (LH) release with half-maximal inhibition (IC50) of about 80 nM.	Tetradecanoylphorbol Acetate	116-119	protein kinase C, gamma	Rattus norvegicus	23-26
1673981-11	1991	Stimulation of T cells with ionomycin and PMA greatly increased the expression of CD2 and CD44 without increasing the number of molecules associated with the cytoskeleton.	Tetradecanoylphorbol Acetate	42-45	CD44 molecule (Indian blood group)	Homo sapiens	90-94
10797562-8	2000	The argininylglycylaspartic acid (RGD) cell-binding region of OPN mediates attachment of TPA-treated JB6 cells because RGD, but not argininylglycylglutamic acid (RGE), peptides inhibited adherence of these cells to OPN in a dose-dependent manner.	Tetradecanoylphorbol Acetate	89-92	secreted phosphoprotein 1	Homo sapiens	62-65
1828153-7	1991	Ang II (10(9) - 10(-8) M) and a protein kinase C activator, phorbol 12-myristate 13-acetate (PMA, 10(-8) M) rapidly induced c-fos as well as c-Jun and Jun-B mRNA expression in RASM cells.	Tetradecanoylphorbol Acetate	60-91	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	124-129
2129223-4	1990	The ability of Et-1 to stimulate both DNA synthesis and anchorage-independent growth was markedly reduced by the depletion of cellular pkC activity induced by prolonged exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	181-217	protein kinase C, gamma	Rattus norvegicus	135-138
10797562-8	2000	The argininylglycylaspartic acid (RGD) cell-binding region of OPN mediates attachment of TPA-treated JB6 cells because RGD, but not argininylglycylglutamic acid (RGE), peptides inhibited adherence of these cells to OPN in a dose-dependent manner.	Tetradecanoylphorbol Acetate	89-92	secreted phosphoprotein 1	Homo sapiens	215-218
2129223-4	1990	The ability of Et-1 to stimulate both DNA synthesis and anchorage-independent growth was markedly reduced by the depletion of cellular pkC activity induced by prolonged exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	219-222	protein kinase C, gamma	Rattus norvegicus	135-138
1828153-7	1991	Ang II (10(9) - 10(-8) M) and a protein kinase C activator, phorbol 12-myristate 13-acetate (PMA, 10(-8) M) rapidly induced c-fos as well as c-Jun and Jun-B mRNA expression in RASM cells.	Tetradecanoylphorbol Acetate	60-91	PYD and CARD domain containing	Rattus norvegicus	138-142
1828153-7	1991	Ang II (10(9) - 10(-8) M) and a protein kinase C activator, phorbol 12-myristate 13-acetate (PMA, 10(-8) M) rapidly induced c-fos as well as c-Jun and Jun-B mRNA expression in RASM cells.	Tetradecanoylphorbol Acetate	93-96	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	124-129
10722731-5	2000	Surprisingly, we observed that expression of N17Ras inhibited the activity and phosphorylation of Elk-1, a physiological substrate of MAP kinases, in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	162-187	ELK1, member of ETS oncogene family	Mus musculus	98-103
1828153-7	1991	Ang II (10(9) - 10(-8) M) and a protein kinase C activator, phorbol 12-myristate 13-acetate (PMA, 10(-8) M) rapidly induced c-fos as well as c-Jun and Jun-B mRNA expression in RASM cells.	Tetradecanoylphorbol Acetate	93-96	PYD and CARD domain containing	Rattus norvegicus	138-142
2040661-6	1991	Other mitogenic agents, 12-0-tetradecanoyl phorbol 13-acetate (TPA) and exogenous phospholipase C, also increased BMM levels of [3H]myristoyl- and [3H]arachidonyl-DAG.	Tetradecanoylphorbol Acetate	63-66	lymphocyte antigen 6 complex	Mus musculus	163-166
1849953-2	1991	In critically ill patients at high risk for the development of septic syndrome (n = 17) peripheral blood PMN were assayed for O2- and H2O2 production after stimulation with phorbol myristate acetate (PMA, 40 nM).	Tetradecanoylphorbol Acetate	173-198	immunoglobulin kappa variable 1D-39	Homo sapiens	126-138
2107490-6	1990	Transcription of the fos, fra-1 and fra-2 genes was induced by phorbol ester (TPA) stimulation of U937 human monocytic cells.	Tetradecanoylphorbol Acetate	78-81	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-24
2107490-6	1990	Transcription of the fos, fra-1 and fra-2 genes was induced by phorbol ester (TPA) stimulation of U937 human monocytic cells.	Tetradecanoylphorbol Acetate	78-81	FOS like 2, AP-1 transcription factor subunit	Homo sapiens	36-41
2107490-7	1990	On TPA stimulation, the transcriptions of fos, fra-1 and fra-2 were detectable after 30, 60 and 120 min and maximum after 60, 90 and 240 min, respectively.	Tetradecanoylphorbol Acetate	3-6	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-45
2107490-7	1990	On TPA stimulation, the transcriptions of fos, fra-1 and fra-2 were detectable after 30, 60 and 120 min and maximum after 60, 90 and 240 min, respectively.	Tetradecanoylphorbol Acetate	3-6	FOS like 2, AP-1 transcription factor subunit	Homo sapiens	57-62
2107492-0	1990	2-Aminopurine abolishes EGF- and TPA-stimulated pp33 phosphorylation and c-fos induction without affecting the activation of protein kinase C. Epidermal Growth Factor (EGF) and Tetradecanoyl Phorbol Acetate (TPA) initiate signalling cascades in C3H 10T1/2 fibroblasts by primarily activating distinct protein kinases, the EGF receptor tyrosine kinase and protein kinase C respectively; there is no signal crossover at the initiation of signalling.	Tetradecanoylphorbol Acetate	33-36	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78
2107492-0	1990	2-Aminopurine abolishes EGF- and TPA-stimulated pp33 phosphorylation and c-fos induction without affecting the activation of protein kinase C. Epidermal Growth Factor (EGF) and Tetradecanoyl Phorbol Acetate (TPA) initiate signalling cascades in C3H 10T1/2 fibroblasts by primarily activating distinct protein kinases, the EGF receptor tyrosine kinase and protein kinase C respectively; there is no signal crossover at the initiation of signalling.	Tetradecanoylphorbol Acetate	177-206	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78
2013762-4	1991	Treatment with PMA increased 32P incorporation into all the peptide fragments that were phosphorylated by 8-BR on both vimentin and GFAP; however, PMA also stimulated phosphorylation of additional fragments of both proteins.	Tetradecanoylphorbol Acetate	15-18	glial fibrillary acidic protein	Homo sapiens	132-136
10694448-8	2000	However, PMA, a phorbol ester that inhibits Col2a1 expression and chondrocyte differentiation, had an unexpectedly modest effect on Sox9 RNA accumulation.	Tetradecanoylphorbol Acetate	9-12	SRY-box 9	Gallus gallus	132-136
1905005-2	1991	We analysed the induction of c-fos mRNA and protein by the protein kinase C (PKC) activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in exponentially growing NIH3T3 fibroblasts transformed by transfection with ras oncogenes.	Tetradecanoylphorbol Acetate	92-129	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-34
1905005-2	1991	We analysed the induction of c-fos mRNA and protein by the protein kinase C (PKC) activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in exponentially growing NIH3T3 fibroblasts transformed by transfection with ras oncogenes.	Tetradecanoylphorbol Acetate	131-134	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-34
1905005-3	1991	We found that H-ras has the unique ability to inhibit c-fos induction by TPA.	Tetradecanoylphorbol Acetate	73-76	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	54-59
2105946-1	1990	AP-1, the polypeptide product of c-jun, recognizes and binds to specific DNA sequences and stimulates transcription of genes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	189-225	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	33-38
2105946-1	1990	AP-1, the polypeptide product of c-jun, recognizes and binds to specific DNA sequences and stimulates transcription of genes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	227-230	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	33-38
2105946-2	1990	We studied the effects of TPA on the regulation of c-jun gene expression in HL-60 cells during monocytic differentiation.	Tetradecanoylphorbol Acetate	26-29	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	51-56
1905005-4	1991	In contrast, normal c-fos expression was induced by TPA in fibroblasts transformed by N- or K-ras or by the ras-unrelated oncogenes dbl and trk.	Tetradecanoylphorbol Acetate	52-55	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-25
10684811-6	2000	In the latter, the protein kinase C agonist phorbol myristate acetate transiently enhanced tissue factor (TF) mRNA levels and elicited a more prolonged elevation in TF protein levels, but did not affect plasminogen activator inhibitor-1 (PAI-1) mRNA and protein levels.	Tetradecanoylphorbol Acetate	44-69	coagulation factor III, tissue factor	Homo sapiens	91-104
1905005-4	1991	In contrast, normal c-fos expression was induced by TPA in fibroblasts transformed by N- or K-ras or by the ras-unrelated oncogenes dbl and trk.	Tetradecanoylphorbol Acetate	52-55	KRAS proto-oncogene, GTPase	Homo sapiens	92-97
1851004-1	1991	Pretreatment of UMR-106 cells (rat osteoblast like osteosarcoma cell line) with the protein kinase C(PK-C) activating phorbol ester, phorbol 12-myristate 13-acetate (PMA) results in a time dependent (1-12h) desensitization of PTH-stimulated cAMP production.	Tetradecanoylphorbol Acetate	133-164	protein kinase C, gamma	Rattus norvegicus	101-105
2105946-3	1990	Low levels of c-jun transcripts were detectable in untreated HL-60 leukemic cells, increased significantly by 6 h, and reached near maximal levels by 24 h of exposure to 32 nM TPA.	Tetradecanoylphorbol Acetate	176-179	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
2105946-4	1990	Similar kinetics of c-jun induction by TPA were observed in human U-937 and THP-1 monocytic leukemia cells.	Tetradecanoylphorbol Acetate	39-42	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-25
2105946-7	1990	TPA treatment of HL-60 cells in the presence of cycloheximide was associated with superinduction of c-jun transcripts.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	100-105
2105946-10	1990	The half-life of c-jun RNA as determined by treating HL-60 cells with TPA and actinomycin D was 30 min.	Tetradecanoylphorbol Acetate	70-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-22
2105946-11	1990	In contrast, the half-life of c-jun RNA in TPA-treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h. These findings suggested that the increase in c-jun RNA observed during TPA-induced monocytic differentiation is mediated by both transcriptional and post-transcriptional mechanisms.	Tetradecanoylphorbol Acetate	43-46	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-35
2105946-11	1990	In contrast, the half-life of c-jun RNA in TPA-treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h. These findings suggested that the increase in c-jun RNA observed during TPA-induced monocytic differentiation is mediated by both transcriptional and post-transcriptional mechanisms.	Tetradecanoylphorbol Acetate	43-46	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-183
1851004-1	1991	Pretreatment of UMR-106 cells (rat osteoblast like osteosarcoma cell line) with the protein kinase C(PK-C) activating phorbol ester, phorbol 12-myristate 13-acetate (PMA) results in a time dependent (1-12h) desensitization of PTH-stimulated cAMP production.	Tetradecanoylphorbol Acetate	166-169	protein kinase C, gamma	Rattus norvegicus	101-105
1851004-3	1991	PK-C inhibitor, H-7 significantly blocked this PMA-induced desensitization.	Tetradecanoylphorbol Acetate	47-50	protein kinase C, gamma	Rattus norvegicus	0-4
2105946-11	1990	In contrast, the half-life of c-jun RNA in TPA-treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h. These findings suggested that the increase in c-jun RNA observed during TPA-induced monocytic differentiation is mediated by both transcriptional and post-transcriptional mechanisms.	Tetradecanoylphorbol Acetate	204-207	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-35
2105946-11	1990	In contrast, the half-life of c-jun RNA in TPA-treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h. These findings suggested that the increase in c-jun RNA observed during TPA-induced monocytic differentiation is mediated by both transcriptional and post-transcriptional mechanisms.	Tetradecanoylphorbol Acetate	204-207	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-183
2013137-6	1991	In conclusion, these studies indicated that strain-dependent differences in the systemic inflammatory response following topical application of TPA may result from direct stimulation of splenic GM precursor cells by TPA and/or may occur, indirectly, through the release of cytokines [e.g. GM colony-stimulating factor (GM-CSF)] by induced epidermal (or other) cells.	Tetradecanoylphorbol Acetate	144-147	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	289-317
10684811-6	2000	In the latter, the protein kinase C agonist phorbol myristate acetate transiently enhanced tissue factor (TF) mRNA levels and elicited a more prolonged elevation in TF protein levels, but did not affect plasminogen activator inhibitor-1 (PAI-1) mRNA and protein levels.	Tetradecanoylphorbol Acetate	44-69	coagulation factor III, tissue factor	Homo sapiens	106-108
2013137-6	1991	In conclusion, these studies indicated that strain-dependent differences in the systemic inflammatory response following topical application of TPA may result from direct stimulation of splenic GM precursor cells by TPA and/or may occur, indirectly, through the release of cytokines [e.g. GM colony-stimulating factor (GM-CSF)] by induced epidermal (or other) cells.	Tetradecanoylphorbol Acetate	144-147	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	319-325
10684811-6	2000	In the latter, the protein kinase C agonist phorbol myristate acetate transiently enhanced tissue factor (TF) mRNA levels and elicited a more prolonged elevation in TF protein levels, but did not affect plasminogen activator inhibitor-1 (PAI-1) mRNA and protein levels.	Tetradecanoylphorbol Acetate	44-69	coagulation factor III, tissue factor	Homo sapiens	165-167
10718373-6	2000	Treatment of PMNs with phorbol myristate acetate (PMA), a protein kinase C activator, completely abolished the intracellular Ca2+ level stimulated by PAF, but not the intracellular Ca2+ level stimulated by fMLP.	Tetradecanoylphorbol Acetate	23-48	PCNA clamp associated factor	Homo sapiens	150-153
19912794-9	1991	In support of this role, the phorbol ester TPA was shown to induce NGF mRNA in L929 cells by Northern analysis.	Tetradecanoylphorbol Acetate	43-46	nerve growth factor	Mus musculus	67-70
1848559-6	1991	Using the PKC activator phorbol myristate acetate (PMA) as the agonist, we found that activation of the respiratory burst oxidase was associated with translocation of cytosolic p47-phox and p67-phox to the plasma membrane as well as redistribution of p47-phox to the Triton-insoluble cytoskeleton.	Tetradecanoylphorbol Acetate	24-49	neutrophil cytosolic factor 1	Homo sapiens	177-185
1848559-6	1991	Using the PKC activator phorbol myristate acetate (PMA) as the agonist, we found that activation of the respiratory burst oxidase was associated with translocation of cytosolic p47-phox and p67-phox to the plasma membrane as well as redistribution of p47-phox to the Triton-insoluble cytoskeleton.	Tetradecanoylphorbol Acetate	51-54	neutrophil cytosolic factor 1	Homo sapiens	177-185
2104941-3	1990	The fos protein made in insect cells manifested most of the characteristics of mammalian fos protein, which include (i) 55-kilodalton size, (ii) nuclear localization, (iii) phosphoesterification at serine residues, (iv) identical 35S tryptic peptide maps, (v) ability to make heterodimers with the nuclear jun oncoprotein, and (vi) cooperation with the jun protein to bind to a 12-O-tetradecanoyl-phorbol-13-acetate-responsive element.	Tetradecanoylphorbol Acetate	378-415	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-7
2104941-3	1990	The fos protein made in insect cells manifested most of the characteristics of mammalian fos protein, which include (i) 55-kilodalton size, (ii) nuclear localization, (iii) phosphoesterification at serine residues, (iv) identical 35S tryptic peptide maps, (v) ability to make heterodimers with the nuclear jun oncoprotein, and (vi) cooperation with the jun protein to bind to a 12-O-tetradecanoyl-phorbol-13-acetate-responsive element.	Tetradecanoylphorbol Acetate	378-415	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-92
10718373-6	2000	Treatment of PMNs with phorbol myristate acetate (PMA), a protein kinase C activator, completely abolished the intracellular Ca2+ level stimulated by PAF, but not the intracellular Ca2+ level stimulated by fMLP.	Tetradecanoylphorbol Acetate	50-53	PCNA clamp associated factor	Homo sapiens	150-153
2005129-10	1991	Endogenous protein kinase C activity in macrophages was depleted by treatment with 12-O-tetradecanoylphorbol-13-acetate for 24 h. GM-CSF increased Egr-1 mRNA in protein kinase C-depleted macrophages, whereas the stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate on Egr-1 was blocked.	Tetradecanoylphorbol Acetate	83-119	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	130-136
2005129-10	1991	Endogenous protein kinase C activity in macrophages was depleted by treatment with 12-O-tetradecanoylphorbol-13-acetate for 24 h. GM-CSF increased Egr-1 mRNA in protein kinase C-depleted macrophages, whereas the stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate on Egr-1 was blocked.	Tetradecanoylphorbol Acetate	234-270	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	130-136
10715542-6	2000	PGS-2 transcripts were highly upregulated in the ovaries by the phorbol ester, phorbol-12-myristate-13-acetate, in combination with the calcium ionophore, A23187.	Tetradecanoylphorbol Acetate	79-110	decorin	Homo sapiens	0-5
2011401-4	1991	In contrast, accumulation of mRNAs for the C-FOS, C-JUN, and EGR-1 genes increased markedly in TPA-treated cells and preceded the induction of IL2R-alpha mRNA.	Tetradecanoylphorbol Acetate	95-98	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	43-48
2326164-7	1990	A free molecular dynamics simulation of a trans-syn d(TpA) photoproduct confirmed all these structural characteristics.	Tetradecanoylphorbol Acetate	54-57	synemin	Homo sapiens	48-51
1688581-7	1990	The level of PI-PLC-sensitive HUVEC DAF was increased three- to fourfold by overnight treatment of cultures with the protein kinase C activators, PMA (1 to 10 nM), phorbol-12,13-dibutyrate (10 to 100 nM), and teleocidin A (1 to 10 nM) under conditions where cell number, protein, and lactate dehydrogenase remain unchanged.	Tetradecanoylphorbol Acetate	146-149	CD55 molecule (Cromer blood group)	Homo sapiens	36-39
1989991-8	1991	Phosphorylation of this protein was also enhanced in response to other secretagogues which, like CCK, stimulate a cascade leading to protein kinase C activation, and in response to direct activation of this enzyme by 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	217-253	cholecystokinin	Rattus norvegicus	97-100
10679481-9	2000	Treatment with FGF-2 or phorbol 12-myristate 13-acetate induced a more continuous pattern of PKCepsilon distribution, whereas the anti-Cx43 staining appeared to overlap extensively with that of PKCepsilon.	Tetradecanoylphorbol Acetate	24-55	protein kinase C epsilon	Homo sapiens	93-103
1899810-7	1991	ODC induction caused by TPA was inhibited by a topical application of cyclooxygenase inhibitor, indomethacin.	Tetradecanoylphorbol Acetate	24-27	ornithine decarboxylase, structural 1	Mus musculus	0-3
2404011-1	1990	12-O-Tetradecanoylphorbol-13-acetate (TPA) activated the c-fos gene enhancer linked to the chloramphenicol acetyltransferase or luciferase reporter gene in the wild type PC-12 cells but not in the variant PC-12 cells that originated from the wild type cells.	Tetradecanoylphorbol Acetate	0-36	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-62
2404011-1	1990	12-O-Tetradecanoylphorbol-13-acetate (TPA) activated the c-fos gene enhancer linked to the chloramphenicol acetyltransferase or luciferase reporter gene in the wild type PC-12 cells but not in the variant PC-12 cells that originated from the wild type cells.	Tetradecanoylphorbol Acetate	38-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-62
2032553-1	1991	Treatment of neutrophils with phorbol myristate acetate (PMA) increases surface expression of CR3 (iC3b-receptor; CD11b/CD18).	Tetradecanoylphorbol Acetate	30-55	integrin subunit alpha M	Homo sapiens	114-119
2032553-1	1991	Treatment of neutrophils with phorbol myristate acetate (PMA) increases surface expression of CR3 (iC3b-receptor; CD11b/CD18).	Tetradecanoylphorbol Acetate	57-60	integrin subunit alpha M	Homo sapiens	114-119
10636851-10	2000	Synergistic promoter activation (&gt;/=100-fold) is observed when PKCepsilon- or -eta-transfected cells are treated with TPA.	Tetradecanoylphorbol Acetate	121-124	protein kinase C epsilon	Homo sapiens	66-77
10625005-4	2000	Ketamine inhibited both the N-formyl-methionyl-leucyl-phenylalanine- and phorbol 12-myristate 13-acetate-induced up-regulation of CD18 and shedding of CD62L, determined by flow cytometry, in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	73-104	selectin L	Homo sapiens	151-156
1851138-5	1991	Under these conditions, dbcAMP was found to interfere with the TPA + ionomycin-mediated induction of c-jun encoding the JUN/AP-1 transcription factor.	Tetradecanoylphorbol Acetate	63-66	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	101-106
1688546-8	1990	Treatment of cardiocytes for 24 hours with either the calcium ionophore A23187 or the phorbol ester 12-O-tetradecanoylphorbol 13-acetate increased ANF secretion.	Tetradecanoylphorbol Acetate	100-136	natriuretic peptide A	Rattus norvegicus	147-150
10630774-4	2000	Using this antibody, cell-surface lactoferrin was measured concurrent with amount of secreted lactoferrin from bovine neutrophils activated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	145-170	lactotransferrin	Bos taurus	94-105
2156121-8	1990	A phorbol ester, PMA, which stimulates protein kinase C, also inhibits ANF-mediated accumulation of cGMP.	Tetradecanoylphorbol Acetate	17-20	natriuretic peptide A	Rattus norvegicus	71-74
10630774-4	2000	Using this antibody, cell-surface lactoferrin was measured concurrent with amount of secreted lactoferrin from bovine neutrophils activated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	172-175	lactotransferrin	Bos taurus	94-105
11052626-5	2000	However, in cells co-expressing Pgp/PKC (alpha or epsilon), pre-treatment with the phorbol ester TPA significantly reduced the swelling-activated 125I efflux with both PKC isoforms.	Tetradecanoylphorbol Acetate	97-100	phosphoglycolate phosphatase	Homo sapiens	32-35
1688390-1	1990	Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion.	Tetradecanoylphorbol Acetate	76-79	protein kinase C, gamma	Rattus norvegicus	84-100
1688390-1	1990	Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion.	Tetradecanoylphorbol Acetate	76-79	protein kinase C, gamma	Rattus norvegicus	102-106
11052626-6	2000	Our results suggest that phosphorylation with the Ca2+ independent variant PKC epsilon does not regulate the ATPase activity of Pgp and that stimulation of PKC with TPA alters the swelling-activated efflux of anions from insect cells expressing Pgp.	Tetradecanoylphorbol Acetate	165-168	phosphoglycolate phosphatase	Homo sapiens	245-248
10683319-3	2000	Tetradecanoyl phorbol acetate (TPA) strongly increased the IL-8 and MCP-1 amounts in the culture supernatants of all five cell lines.	Tetradecanoylphorbol Acetate	0-29	C-C motif chemokine ligand 2	Homo sapiens	68-73
22760862-4	2013	The GOH treatment also resulted in reduction of TPA-induced ornithine decarboxylase activity and [(3) H] thymidine incorporation by 53% (P &lt; 0.001) and 41% (P &lt; 0.001), respectively.	Tetradecanoylphorbol Acetate	48-51	ornithine decarboxylase, structural 1	Mus musculus	60-83
10683319-3	2000	Tetradecanoyl phorbol acetate (TPA) strongly increased the IL-8 and MCP-1 amounts in the culture supernatants of all five cell lines.	Tetradecanoylphorbol Acetate	31-34	C-C motif chemokine ligand 2	Homo sapiens	68-73
10872872-5	2000	The latent EBV was reactivated with high concentrations of TPA as shown by the expression of EBV BZLF1 gene product ZEBRA.	Tetradecanoylphorbol Acetate	59-62	protein Zta	Human gammaherpesvirus 4	97-102
21454541-4	2011	Interestingly, silencing p23 from LNCaP prostate cancer cells using RNAi markedly enhanced PKCdelta-dependent apoptosis and activation of PKCdelta downstream effectors ROCK and JNK by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	184-215	transmembrane p24 trafficking protein 10	Homo sapiens	25-28
21454541-5	2011	Moreover, translocation of PKCdelta to the plasma membrane by phorbol 12-myristate 13-acetate was enhanced in p23-depleted LNCaP cells.	Tetradecanoylphorbol Acetate	62-93	transmembrane p24 trafficking protein 10	Homo sapiens	110-113
10590260-9	1999	We investigated the functional significance of NFATp binding to CK-1 by overexpressing the protein in Jurkat T cells and found that NFATp cannot activate the CD28RR alone but can cooperate with signals generated by phorbol 12-myristate 13-acetate/calcium ionophore.	Tetradecanoylphorbol Acetate	215-246	nuclear factor of activated T cells 2	Homo sapiens	47-52
19521892-9	2009	Treatment with rHDL induced disruption of the lipid raft structures and blunted PMA-induced redistribution of p47phox into lipid rafts.	Tetradecanoylphorbol Acetate	80-83	neutrophil cytosolic factor 1	Homo sapiens	110-117
10528234-9	1999	Both the cyclic adenosine monophosphate (cAMP) analogue, 8-bromo-cAMP (8-Br-cAMP), and the protein kinase C (PKC) activator, phorbol myristate acetate, increased collagenase-3 expression, while the calcium ionophore, ionomycin, did not, suggesting that PTH was acting through the protein kinase A (PKA) and PKC pathways.	Tetradecanoylphorbol Acetate	125-150	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	280-296
10528234-9	1999	Both the cyclic adenosine monophosphate (cAMP) analogue, 8-bromo-cAMP (8-Br-cAMP), and the protein kinase C (PKC) activator, phorbol myristate acetate, increased collagenase-3 expression, while the calcium ionophore, ionomycin, did not, suggesting that PTH was acting through the protein kinase A (PKA) and PKC pathways.	Tetradecanoylphorbol Acetate	125-150	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	298-301
10588815-3	1999	In this study, we examined direct effects of LH, the proinflammatory cytokine, interleukin-1beta (IL-1beta), and pharmacological activators of protein kinase A (PKA) (forskolin and dibutyryl (db) cAMP) and PKC (LH-releasing hormone and phorbol 12-myristate 13-acetate (PMA)) signalling on the expression of 11betaHSD1 mRNA in vitro.	Tetradecanoylphorbol Acetate	236-267	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	161-164
34866386-3	2022	TPA-TRDN could selectively detect HSA with fast response (10 min), superior sensitivity (LOD 0.34 mug/mL, about 60-fold fluorescence enhancement), and wide detection range (0.00-0.30 mg/mL).	Tetradecanoylphorbol Acetate	0-3	triadin	Homo sapiens	4-8
10588815-3	1999	In this study, we examined direct effects of LH, the proinflammatory cytokine, interleukin-1beta (IL-1beta), and pharmacological activators of protein kinase A (PKA) (forskolin and dibutyryl (db) cAMP) and PKC (LH-releasing hormone and phorbol 12-myristate 13-acetate (PMA)) signalling on the expression of 11betaHSD1 mRNA in vitro.	Tetradecanoylphorbol Acetate	269-272	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	161-164
10561508-1	1999	Epidermal growth factor (EGF), insulin-like growth factor 1 (IGF1) and phorbol myristate acetate (PMA) induce the inhibition of glycogen synthase kinase 3 (GSK3) by stimulating the phosphorylation of an N-terminal serine.	Tetradecanoylphorbol Acetate	71-96	glycogen synthase kinase 3 beta	Mus musculus	128-154
34635253-1	2022	A conjugated microporous organic polymer (TPA-Bp) comprised of triphenylamine (TPA) and 2,2"-bipyridine-5,5"-diformaldehyde (Bp) was prepared via the Schiff-base reaction under ambient conditions.	Tetradecanoylphorbol Acetate	79-82	poly(A) binding protein cytoplasmic 3	Homo sapiens	42-48
34903321-6	2022	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) changed the expression levels of EMT markers, increasing alpha-SMA, vimentin, and MMP-9 expression and decreasing E-cadherin expression, with changes in cell morphology.	Tetradecanoylphorbol Acetate	15-51	matrix metallopeptidase 9	Homo sapiens	140-145
34903321-6	2022	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) changed the expression levels of EMT markers, increasing alpha-SMA, vimentin, and MMP-9 expression and decreasing E-cadherin expression, with changes in cell morphology.	Tetradecanoylphorbol Acetate	53-56	matrix metallopeptidase 9	Homo sapiens	140-145
34903321-9	2022	Inhibition of aurora kinase A blocked TPA-induced vimentin and MMP-9 expression, and decreased E-cadherin expression.	Tetradecanoylphorbol Acetate	38-41	matrix metallopeptidase 9	Homo sapiens	63-68
34499332-3	2021	In this study, rats were treated with aluminum maltol (Al(mal)3) to establish a toxic animal model and PMA was used to interfere with the expression of PKC.	Tetradecanoylphorbol Acetate	103-106	protein kinase C, gamma	Rattus norvegicus	152-155
34780714-5	2022	Although mRNA levels of inflammatory cytokines in skin after topical application of 12-O-tetradecanoylphorbol-13-acetate or imiquimod were comparable between kCYC+/- and wild-type mice, protein levels of inflammatory cytokines such as interleukin (IL)-17A, IL-22, and IL-23 were significantly upregulated in kCYC+/- mice in both models.	Tetradecanoylphorbol Acetate	84-120	interleukin 17A	Mus musculus	235-255
34804038-7	2021	However, EBV exposure impaired the cytokine (IFN-gamma, IL-2, and TNF-alpha) secretion capability of CD4+ and CD8+ T cells after stimulation with PMA/ionomycin in vitro.	Tetradecanoylphorbol Acetate	146-149	CD8a molecule	Homo sapiens	110-113
34713658-5	2021	The results showed that both PMA and LPS were able to induce firmly adhered neutrophils on ICAM-1 to produce NETs.	Tetradecanoylphorbol Acetate	29-32	intercellular adhesion molecule 1	Homo sapiens	91-97
34157522-7	2021	RESULTS: The results showed that serum levels of IL-38 were significantly increased after tPA therapy (P < 0.001).	Tetradecanoylphorbol Acetate	90-93	interleukin 1 family member 10	Homo sapiens	49-54
34224996-6	2021	In vitro experiments were performed to detect the level of MPO-DNA complex released by SEI-treated neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA) or co-cultured with platelets from CLP mice.	Tetradecanoylphorbol Acetate	127-158	myeloperoxidase	Mus musculus	59-62
34224996-6	2021	In vitro experiments were performed to detect the level of MPO-DNA complex released by SEI-treated neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA) or co-cultured with platelets from CLP mice.	Tetradecanoylphorbol Acetate	160-163	myeloperoxidase	Mus musculus	59-62
34224996-13	2021	In vitro experiments showed that the MPO-DNA level stimulated by PMA was significantly reduced by SEI treatment (P < 0.05 compared with DMSO treatment).	Tetradecanoylphorbol Acetate	65-68	myeloperoxidase	Mus musculus	37-40
34359010-0	2021	A novel commentary: Investigation of the role of a balance between neurotrophic and apoptotic proteins in the pathogenesis of psychosis via the tPA-BDNF pathway.	Tetradecanoylphorbol Acetate	144-147	brain derived neurotrophic factor	Homo sapiens	148-152
34572313-0	2021	The FcgammaRIII Engagement Augments PMA-Stimulated Neutrophil Extracellular Traps (NETs) Formation by Granulocytes Partially via Cross-Talk between Syk-ERK-NF-kappaB and PKC-ROS Signaling Pathways.	Tetradecanoylphorbol Acetate	36-39	Fc gamma receptor IIIa	Homo sapiens	4-15
34572313-0	2021	The FcgammaRIII Engagement Augments PMA-Stimulated Neutrophil Extracellular Traps (NETs) Formation by Granulocytes Partially via Cross-Talk between Syk-ERK-NF-kappaB and PKC-ROS Signaling Pathways.	Tetradecanoylphorbol Acetate	36-39	spleen associated tyrosine kinase	Homo sapiens	148-151
34483941-7	2021	Additionally, FM-CATH affected the enzymatic activities of thrombin, plasmin, beta-tryptase, and tPA, leading to coagulation inhibition in vitro and in vivo.	Tetradecanoylphorbol Acetate	97-100	cathepsin H	Mus musculus	17-21
34512147-7	2021	We further demonstrate that c-Jun, AR, and DNA methyltransferase-1 (DNMT1) form a complex in the 12-O-tetradecanoyl phorbol-13-acetate (TPA) response elements (TREs) region of the NDRG1 promoter, which suppresses NDRG1 transcription through DNA hypermethylation.	Tetradecanoylphorbol Acetate	97-134	N-myc downstream regulated 1	Homo sapiens	213-218
34512147-7	2021	We further demonstrate that c-Jun, AR, and DNA methyltransferase-1 (DNMT1) form a complex in the 12-O-tetradecanoyl phorbol-13-acetate (TPA) response elements (TREs) region of the NDRG1 promoter, which suppresses NDRG1 transcription through DNA hypermethylation.	Tetradecanoylphorbol Acetate	136-139	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-33
34512147-7	2021	We further demonstrate that c-Jun, AR, and DNA methyltransferase-1 (DNMT1) form a complex in the 12-O-tetradecanoyl phorbol-13-acetate (TPA) response elements (TREs) region of the NDRG1 promoter, which suppresses NDRG1 transcription through DNA hypermethylation.	Tetradecanoylphorbol Acetate	136-139	DNA methyltransferase 1	Homo sapiens	43-66
34512147-7	2021	We further demonstrate that c-Jun, AR, and DNA methyltransferase-1 (DNMT1) form a complex in the 12-O-tetradecanoyl phorbol-13-acetate (TPA) response elements (TREs) region of the NDRG1 promoter, which suppresses NDRG1 transcription through DNA hypermethylation.	Tetradecanoylphorbol Acetate	136-139	DNA methyltransferase 1	Homo sapiens	68-73
34512147-7	2021	We further demonstrate that c-Jun, AR, and DNA methyltransferase-1 (DNMT1) form a complex in the 12-O-tetradecanoyl phorbol-13-acetate (TPA) response elements (TREs) region of the NDRG1 promoter, which suppresses NDRG1 transcription through DNA hypermethylation.	Tetradecanoylphorbol Acetate	136-139	N-myc downstream regulated 1	Homo sapiens	180-185
34512147-7	2021	We further demonstrate that c-Jun, AR, and DNA methyltransferase-1 (DNMT1) form a complex in the 12-O-tetradecanoyl phorbol-13-acetate (TPA) response elements (TREs) region of the NDRG1 promoter, which suppresses NDRG1 transcription through DNA hypermethylation.	Tetradecanoylphorbol Acetate	136-139	N-myc downstream regulated 1	Homo sapiens	213-218
35197329-0	2022	Aberrant HO-1/NQO1-Reactive Oxygen Species-ERK Signaling Pathway Contributes to Aggravation of TPA-Induced Irritant Contact Dermatitis in Nrf2-Deficient Mice.	Tetradecanoylphorbol Acetate	95-98	NAD(P)H dehydrogenase, quinone 1	Mus musculus	14-18
35166073-4	2022	METHODS: IL-17A production from 5 sorted peripheral blood cell populations, namely MAITs, gammadelta T-cells, CD4+T-cells, CD8+T-cells and neutrophils was evaluated pre- and post-stimulation with PMA, the calcium ionophore A23187 and beta1,3 glucan.	Tetradecanoylphorbol Acetate	196-199	interleukin 17A	Homo sapiens	9-15
35068054-4	2022	Furthermore, PPP2CB deletion did not affect T cell receptor (TCR)-induced T cell activation or cytokine-induced T cell responses; however, it specifically enhanced phorbol myristate acetate (PMA) plus ionomycin-induced T cell activation with increased cellular proliferation, elevated CD69 and CD25 expression, and enhanced cytokines production (IFN-gamma, IL-2 and TNF).	Tetradecanoylphorbol Acetate	164-189	interleukin 2 receptor, alpha chain	Mus musculus	294-298
35095881-8	2021	Patients bearing effector memory CD4 and CD8 T cells with the phenotype of high MD exhibited poorer T-cell responses upon either phorbol 12-myristate-13-acetate (PMA)/ionomycin or SARS-CoV-2 peptide stimulation than those with low MD.	Tetradecanoylphorbol Acetate	162-165	CD8a molecule	Homo sapiens	41-44
2531661-3	1989	Consistent with studies demonstrating that the AP1 site mediates signal transduction in response to 12-O-tetradecanoylphorbol 13-acetate (TPA) we have shown that TPA can activate Ad-EIII expression and overcome the requirement for EIa.	Tetradecanoylphorbol Acetate	100-136	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-50
2531661-3	1989	Consistent with studies demonstrating that the AP1 site mediates signal transduction in response to 12-O-tetradecanoylphorbol 13-acetate (TPA) we have shown that TPA can activate Ad-EIII expression and overcome the requirement for EIa.	Tetradecanoylphorbol Acetate	138-141	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-50
2531661-3	1989	Consistent with studies demonstrating that the AP1 site mediates signal transduction in response to 12-O-tetradecanoylphorbol 13-acetate (TPA) we have shown that TPA can activate Ad-EIII expression and overcome the requirement for EIa.	Tetradecanoylphorbol Acetate	162-165	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-50
2531661-6	1989	An EIII promoter construct, in which sequences upstream of the TATA box had been replaced with four AP1 sites, was responsive to TPA and EIa and in combination promoted the synergistic effect.	Tetradecanoylphorbol Acetate	129-132	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	100-103
2602143-0	1989	Regulation of mouse ornithine decarboxylase activity by cell growth, serum and tetradecanoyl phorbol acetate is governed primarily by sequences within the coding region of the gene.	Tetradecanoylphorbol Acetate	79-108	ornithine decarboxylase, structural 1	Mus musculus	20-43
2602143-1	1989	To determine the genetic elements required for modulation of ornithine decarboxylase (ODC) activity in response to cell growth or treatment with serum or with tetradecanoyl phorbol acetate, ODC-deficient cells were transfected with a series of recombinant DNAs encoding mouse ODC.	Tetradecanoylphorbol Acetate	159-188	ornithine decarboxylase, structural 1	Mus musculus	61-84
2602143-1	1989	To determine the genetic elements required for modulation of ornithine decarboxylase (ODC) activity in response to cell growth or treatment with serum or with tetradecanoyl phorbol acetate, ODC-deficient cells were transfected with a series of recombinant DNAs encoding mouse ODC.	Tetradecanoylphorbol Acetate	159-188	ornithine decarboxylase, structural 1	Mus musculus	86-89
2591024-7	1989	Additionally, on this dosing regimen, the peak of ODC activity shifted to approximately 4 h after the last treatment, so that the time-course of ODC induction resembled that after multiple applications of TPA.	Tetradecanoylphorbol Acetate	205-208	ornithine decarboxylase, structural 1	Mus musculus	50-53
1908616-3	1991	Curcumin is a potent inhibitor of TPA-induced ornithine decarboxylase activity and inflammation in mouse skin whereas chlorogenic acid, caffeic acid and ferulic acid are only weakly active or inactive.	Tetradecanoylphorbol Acetate	34-37	ornithine decarboxylase, structural 1	Mus musculus	46-69
2007095-5	1991	In contrast, treatment with TPA was associated with rapid increases in jun-B mRNA levels that were maximal at 3 h and remained elevated at 48 h. The induction of jun-B expression by TPA in these cells preceded that of the c-jun and c-fos genes.	Tetradecanoylphorbol Acetate	28-31	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	222-227
2007095-5	1991	In contrast, treatment with TPA was associated with rapid increases in jun-B mRNA levels that were maximal at 3 h and remained elevated at 48 h. The induction of jun-B expression by TPA in these cells preceded that of the c-jun and c-fos genes.	Tetradecanoylphorbol Acetate	28-31	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	232-237
2007095-5	1991	In contrast, treatment with TPA was associated with rapid increases in jun-B mRNA levels that were maximal at 3 h and remained elevated at 48 h. The induction of jun-B expression by TPA in these cells preceded that of the c-jun and c-fos genes.	Tetradecanoylphorbol Acetate	182-185	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	222-227
2007095-5	1991	In contrast, treatment with TPA was associated with rapid increases in jun-B mRNA levels that were maximal at 3 h and remained elevated at 48 h. The induction of jun-B expression by TPA in these cells preceded that of the c-jun and c-fos genes.	Tetradecanoylphorbol Acetate	182-185	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	232-237
1722684-0	1991	Thyrotropin inhibits while insulin, epidermal growth factor and tetradecanoyl phorbol acetate stimulate insulin-like growth factor binding protein secretion from sheep thyroid cells.	Tetradecanoylphorbol Acetate	64-93	LOC105613195	Ovis aries	104-111
1722684-11	1991	TPA treatment increased IGFBP-2 mRNA.	Tetradecanoylphorbol Acetate	0-3	insulin-like growth factor-binding protein 2	Ovis aries	24-31
1958524-3	1991	E2 by itself, however, is poorly mitogenic and it does not induce genes from the jun family, whose gene products are necessary for heterodimerization with the c-fos encoded protein (Fos), leading to an important step in growth factor signalling pathways, stimulation of the 12-O-tetradecanoyl-phorbol-13-acetate responsive element (TRE)-dependent transcriptional activity.	Tetradecanoylphorbol Acetate	274-311	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-185
1671790-1	1991	In the present study, we investigated the effects of calmodulin, adenosine 5"-triphosphate (ATP) and pertussis toxin (PT) on phorbol ester (PMA) (a protein kinase C activator) induced inhibition of ANF-stimulated cyclic GMP formation in cells from the human renal cell line, SK-NEP-1.	Tetradecanoylphorbol Acetate	140-143	EMG1 N1-specific pseudouridine methyltransferase	Homo sapiens	278-283
10561508-1	1999	Epidermal growth factor (EGF), insulin-like growth factor 1 (IGF1) and phorbol myristate acetate (PMA) induce the inhibition of glycogen synthase kinase 3 (GSK3) by stimulating the phosphorylation of an N-terminal serine.	Tetradecanoylphorbol Acetate	71-96	glycogen synthase kinase 3 beta	Mus musculus	156-160
1857220-0	1991	Purification of amphiregulin from serum-free conditioned medium of 12-O-tetradecanoylphorbol 13-acetate-treated cell lines.	Tetradecanoylphorbol Acetate	67-103	amphiregulin	Homo sapiens	16-28
2591024-7	1989	Additionally, on this dosing regimen, the peak of ODC activity shifted to approximately 4 h after the last treatment, so that the time-course of ODC induction resembled that after multiple applications of TPA.	Tetradecanoylphorbol Acetate	205-208	ornithine decarboxylase, structural 1	Mus musculus	145-148
10497314-3	1999	We observed that the expression of the exogenous wild type MacMARCKS greatly enhanced LFA-1-mediated cell-cell adhesion in U937 cells treated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	147-178	MARCKS like 1	Homo sapiens	59-68
2601687-1	1989	12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	0-36	ornithine decarboxylase, structural 1	Mus musculus	51-74
2601687-1	1989	12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	0-36	ornithine decarboxylase, structural 1	Mus musculus	76-79
2601687-1	1989	12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	38-41	ornithine decarboxylase, structural 1	Mus musculus	51-74
2601687-1	1989	12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	38-41	ornithine decarboxylase, structural 1	Mus musculus	76-79
2601687-2	1989	TPA (30 nM)-caused ODC induction was almost completely blocked by 30 microM H-7 [1-(5-isoquinolinylsulfonyl)-2-methylpiperazine], a well known protein kinase C inhibitor, but the same concentration of H-7 failed to restore the 125I-EGF binding suppressed by TPA (10 nM).	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	19-22
2601687-2	1989	TPA (30 nM)-caused ODC induction was almost completely blocked by 30 microM H-7 [1-(5-isoquinolinylsulfonyl)-2-methylpiperazine], a well known protein kinase C inhibitor, but the same concentration of H-7 failed to restore the 125I-EGF binding suppressed by TPA (10 nM).	Tetradecanoylphorbol Acetate	258-261	ornithine decarboxylase, structural 1	Mus musculus	19-22
2601687-3	1989	On the other hand, sphingosine, another protein kinase C inhibitor, blocked not only TPA-caused ODC induction but also TPA-caused suppression of 125I-EGF binding.	Tetradecanoylphorbol Acetate	85-88	ornithine decarboxylase, structural 1	Mus musculus	96-99
1898988-4	1991	Furthermore, application of 5 micrograms TPA to mouse skin rapidly caused accumulation of ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	41-44	ornithine decarboxylase, structural 1	Mus musculus	90-113
1898988-4	1991	Furthermore, application of 5 micrograms TPA to mouse skin rapidly caused accumulation of ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	41-44	ornithine decarboxylase, structural 1	Mus musculus	115-118
1898988-5	1991	Similarly, sitosterol and lupane-type triterpene derivatives markedly inhibited this TPA-induced ODC accumulation.	Tetradecanoylphorbol Acetate	85-88	ornithine decarboxylase, structural 1	Mus musculus	97-100
2147223-1	1990	A DNA element located at positions -295 to -289 of the c-fos promoter (FAP site) is highly homologous to a consensus 12-O-tetradecanoyl phorbol-13-acetate-responsive element (TRE) and to a cyclic AMP (cAMP)-responsive element (CRE).	Tetradecanoylphorbol Acetate	117-154	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-60
2244911-8	1990	Prolonged exposure of HUVEC to phorbol myristate acetate down-regulated PKC activity and inhibited subsequent ICAM-1 up-regulation by this agent and by IL-1.	Tetradecanoylphorbol Acetate	31-56	intercellular adhesion molecule 1	Homo sapiens	110-116
10497314-3	1999	We observed that the expression of the exogenous wild type MacMARCKS greatly enhanced LFA-1-mediated cell-cell adhesion in U937 cells treated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	180-183	MARCKS like 1	Homo sapiens	59-68
10543954-5	1999	Surface plasmon resonance revealed that the affinity of initial reversible complex formation between PAI-1 and catalytically inactive Ser195--&gt;Ala variants of thrombin and thrombin-VR1(tPA) is only increased fivefold, i.e. KD is 652 and 128 nM for thrombin-S195A and thrombin-S195A-VR1(tPA), respectively.	Tetradecanoylphorbol Acetate	188-191	vault RNA 1-1	Homo sapiens	285-288
10543954-5	1999	Surface plasmon resonance revealed that the affinity of initial reversible complex formation between PAI-1 and catalytically inactive Ser195--&gt;Ala variants of thrombin and thrombin-VR1(tPA) is only increased fivefold, i.e. KD is 652 and 128 nM for thrombin-S195A and thrombin-S195A-VR1(tPA), respectively.	Tetradecanoylphorbol Acetate	289-292	serpin family E member 1	Homo sapiens	101-106
1976513-2	1990	The cells were treated with the phorbol ester TPA, which not only activates PKC but also causes down-regulation.	Tetradecanoylphorbol Acetate	46-49	protein kinase C, gamma	Rattus norvegicus	76-79
10543954-5	1999	Surface plasmon resonance revealed that the affinity of initial reversible complex formation between PAI-1 and catalytically inactive Ser195--&gt;Ala variants of thrombin and thrombin-VR1(tPA) is only increased fivefold, i.e. KD is 652 and 128 nM for thrombin-S195A and thrombin-S195A-VR1(tPA), respectively.	Tetradecanoylphorbol Acetate	289-292	vault RNA 1-1	Homo sapiens	184-187
1976513-4	1990	The [3H]PDBU binding to the membrane-associated PKC increased within 15-30 min of TPA treatment; thereafter total cellular [3H]PDBU binding decreased to a minimum of 20% of the control at 8 h. The rate of decrease in binding was greater than the decrease in the intensity of the staining of PKC holo enzyme visualized by anti-PKC antibody.	Tetradecanoylphorbol Acetate	82-85	protein kinase C, gamma	Rattus norvegicus	48-51
2555310-3	1989	Measurement of protein kinase C (PKC) activity in isolated fractions showed a substantial reduction of the total cellular PKC activity and of the activity in the cytosolic fraction following incubation of cells with 10(-8) M PMA for 30 min.	Tetradecanoylphorbol Acetate	225-228	protein kinase C, gamma	Rattus norvegicus	15-31
2555310-3	1989	Measurement of protein kinase C (PKC) activity in isolated fractions showed a substantial reduction of the total cellular PKC activity and of the activity in the cytosolic fraction following incubation of cells with 10(-8) M PMA for 30 min.	Tetradecanoylphorbol Acetate	225-228	protein kinase C, gamma	Rattus norvegicus	33-36
10543954-7	1999	Hirugen allosterically decreases the rate of thrombin inhibition by PAI-1 2.5-fold and of thrombin-VR1(tPA) 20-fold, by interfering with a unimolecular step in the reaction, not by decreasing initial complex formation or by altering the stoichiometry.	Tetradecanoylphorbol Acetate	103-106	vault RNA 1-1	Homo sapiens	99-102
2555310-3	1989	Measurement of protein kinase C (PKC) activity in isolated fractions showed a substantial reduction of the total cellular PKC activity and of the activity in the cytosolic fraction following incubation of cells with 10(-8) M PMA for 30 min.	Tetradecanoylphorbol Acetate	225-228	protein kinase C, gamma	Rattus norvegicus	122-125
2104232-4	1990	Also the NF-kappa B from the human T-cell line Jurkat, activated upon phytohemagglutinin (PHA)/phorbol 12-myristate 13-acetate (PMA/TPA) treatment in vivo or upon deoxycholate treatment in vitro, binds with high affinity to the sequence in the TNF-beta promoter.	Tetradecanoylphorbol Acetate	128-131	lymphotoxin alpha	Homo sapiens	244-252
10543954-8	1999	Finally, kinetic modeling demonstrated that acylation is the rate-limiting step in thrombin inhibition by PAI-1 (k approximately 10(-3) s(-1)) and this kinetic block is alleviated by the introduction of the tPA-VR1 into thrombin (k&gt;1 s(-1)).	Tetradecanoylphorbol Acetate	207-210	serpin family E member 1	Homo sapiens	106-111
10543954-8	1999	Finally, kinetic modeling demonstrated that acylation is the rate-limiting step in thrombin inhibition by PAI-1 (k approximately 10(-3) s(-1)) and this kinetic block is alleviated by the introduction of the tPA-VR1 into thrombin (k&gt;1 s(-1)).	Tetradecanoylphorbol Acetate	207-210	vault RNA 1-1	Homo sapiens	211-214
10497257-2	1999	The addition of phorbol ester (PMA, phorbol 12-myristate 13-acetate) to cells expressing HB-EGF(TM) results in the metalloproteinase-dependent release (shedding) of soluble HB-EGF.	Tetradecanoylphorbol Acetate	31-34	heparin binding EGF like growth factor	Homo sapiens	89-95
2226643-2	1990	In HEL-30 cells, protein kinase C activation is followed by ornithine decarboxylase stimulation and cell proliferation, events inhibited by H-7, a specific inhibitor of protein kinase C. TPA in NCTC cells inhibited the basal ornithine decarboxylase activity and cell growth, whereas H-7 did not modify TPA effect.	Tetradecanoylphorbol Acetate	187-190	ornithine decarboxylase, structural 1	Mus musculus	60-83
2674135-3	1989	The inhibitory effect of the B subunit was observed even in the presence of insulin, which greatly potentiates the mitogenic response to TPA or the B subunit.	Tetradecanoylphorbol Acetate	137-140	Insulin-like receptor	Drosophila melanogaster	76-83
2226643-2	1990	In HEL-30 cells, protein kinase C activation is followed by ornithine decarboxylase stimulation and cell proliferation, events inhibited by H-7, a specific inhibitor of protein kinase C. TPA in NCTC cells inhibited the basal ornithine decarboxylase activity and cell growth, whereas H-7 did not modify TPA effect.	Tetradecanoylphorbol Acetate	187-190	ornithine decarboxylase, structural 1	Mus musculus	225-248
10497257-2	1999	The addition of phorbol ester (PMA, phorbol 12-myristate 13-acetate) to cells expressing HB-EGF(TM) results in the metalloproteinase-dependent release (shedding) of soluble HB-EGF.	Tetradecanoylphorbol Acetate	31-34	heparin binding EGF like growth factor	Homo sapiens	173-179
2673548-3	1989	Small tonsil B cells activated in vitro with either PWM, phorbol 12-myristate 13-acetate (TPA), or anti-Ig plus low Mr B cell growth factor (BCGF) also demonstrated increased CD9 expression.	Tetradecanoylphorbol Acetate	57-88	CD9 molecule	Homo sapiens	175-178
10497257-2	1999	The addition of phorbol ester (PMA, phorbol 12-myristate 13-acetate) to cells expressing HB-EGF(TM) results in the metalloproteinase-dependent release (shedding) of soluble HB-EGF.	Tetradecanoylphorbol Acetate	36-67	heparin binding EGF like growth factor	Homo sapiens	89-95
2673548-3	1989	Small tonsil B cells activated in vitro with either PWM, phorbol 12-myristate 13-acetate (TPA), or anti-Ig plus low Mr B cell growth factor (BCGF) also demonstrated increased CD9 expression.	Tetradecanoylphorbol Acetate	90-93	CD9 molecule	Homo sapiens	175-178
2673548-7	1989	Two phorbols that activate protein kinase C (TPA; phorbol 12,13-dibutyrate) induced expression of the CD9 antigen whereas a phorbol analogue that does not activate C kinase (4-alpha-phorbol 12,13-didecanoate) and an analogue that is a very weak agonist (phorbol 12-myristate 13-acetate-4-0-methyl ether) were unable to induce CD9 expression on tonsil B cells or on the cell lines.	Tetradecanoylphorbol Acetate	45-48	CD9 molecule	Homo sapiens	102-105
1978837-8	1990	The level of beta-actin mRNA was elevated in resting cells by epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate and to a lesser extent by fibroblast growth factor, insulin, and dibutyryl cyclic AMP-elevating agents.	Tetradecanoylphorbol Acetate	90-126	actin, beta	Mus musculus	13-23
10497257-2	1999	The addition of phorbol ester (PMA, phorbol 12-myristate 13-acetate) to cells expressing HB-EGF(TM) results in the metalloproteinase-dependent release (shedding) of soluble HB-EGF.	Tetradecanoylphorbol Acetate	36-67	heparin binding EGF like growth factor	Homo sapiens	173-179
10603431-3	1999	As a result, tPA activity was significantly increased in CA1-CA4 and the dentate gyrus after TMT injection.	Tetradecanoylphorbol Acetate	13-16	carbonic anhydrase 1	Mus musculus	57-60
2266662-7	1990	Activation of protein kinase C (PKC) by phorbol myristate acetate (PMA) also decreased C-mediated cytolysis.	Tetradecanoylphorbol Acetate	40-65	protein kinase C, gamma	Rattus norvegicus	32-35
2266662-7	1990	Activation of protein kinase C (PKC) by phorbol myristate acetate (PMA) also decreased C-mediated cytolysis.	Tetradecanoylphorbol Acetate	67-70	protein kinase C, gamma	Rattus norvegicus	14-30
2266662-7	1990	Activation of protein kinase C (PKC) by phorbol myristate acetate (PMA) also decreased C-mediated cytolysis.	Tetradecanoylphorbol Acetate	67-70	protein kinase C, gamma	Rattus norvegicus	32-35
2266662-8	1990	Conversely, C lysis was enhanced in GEC that had been pretreated for 18 hours with a high dose of PMA to deplete PKC, and following PKC inhibition with H-7.	Tetradecanoylphorbol Acetate	98-101	protein kinase C, gamma	Rattus norvegicus	113-116
2673548-7	1989	Two phorbols that activate protein kinase C (TPA; phorbol 12,13-dibutyrate) induced expression of the CD9 antigen whereas a phorbol analogue that does not activate C kinase (4-alpha-phorbol 12,13-didecanoate) and an analogue that is a very weak agonist (phorbol 12-myristate 13-acetate-4-0-methyl ether) were unable to induce CD9 expression on tonsil B cells or on the cell lines.	Tetradecanoylphorbol Acetate	45-48	CD9 molecule	Homo sapiens	326-329
10551153-10	1999	GM-CSF (50 IU/ml) also significantly increased IL-8 production from 2-7 days of treatment of THP-1 cells when supplemented with a positive control, phorbol-12-myristate-13 acetate (PMA), as compared to PMA treatment alone.	Tetradecanoylphorbol Acetate	148-179	colony stimulating factor 2	Homo sapiens	0-6
2507555-2	1989	We have previously shown that agents capable of activating protein kinase C (PKC), such as FGF and the phorbol ester tetradecanoyl phorbol-13-acetate (TPA), inhibit the differentiation of the adipogenic cell line TA1, as measured by the rapid loss of adipocyte-specific RNAs.	Tetradecanoylphorbol Acetate	151-154	trace amine associated receptor 1	Homo sapiens	213-216
2507555-3	1989	We report here that the treatment of fully differentiated TA1 adipocytes with FGF at 10 ng/ml induces the reversal of adipocyte differentiation, even in cells where PKC activity has been down-regulated by TPA pretreatment.	Tetradecanoylphorbol Acetate	205-208	trace amine associated receptor 1	Homo sapiens	58-61
2507555-4	1989	In contrast, TPA or lower concentrations of FGF (1 ng/ml), both effective inducers of c-fos RNA in adipocytes, fail to reverse adipocyte differentiation.	Tetradecanoylphorbol Acetate	13-16	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-91
2126340-6	1990	E2 by itself, however, is poorly mitogenic, and it does not induce genes from the jun family, whose gene products are necessary for heterodimerization with the c-fos-encoded protein (Fos), leading to an important step in growth factor signalling pathways, stimulation of TPA-responsive element (TRE)-dependent transcriptional activity.	Tetradecanoylphorbol Acetate	271-274	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	183-186
1698561-4	1990	CD5 upregulation on TPA-sensitive JM cells appears correlated with inhibition of cell growth, blockage in G1 phase, and phenotypic maturation (downregulation of CD7 and CD1 antigens) and seemed to be related to PKC activation since DiC8 (a PKC activator) mimicked this TPA effect and H7 (a PKC inhibitor) partially reduced it.	Tetradecanoylphorbol Acetate	20-23	CD7 molecule	Homo sapiens	161-164
2507555-6	1989	Therefore, we propose that there are two FGF-sensitive pathways in TA1 cells: one responsible for the initiation of differentiation (TPA sensitive) and another required for maintenance of the adipose phenotype (TPA insensitive).	Tetradecanoylphorbol Acetate	133-136	trace amine associated receptor 1	Homo sapiens	67-70
10551153-10	1999	GM-CSF (50 IU/ml) also significantly increased IL-8 production from 2-7 days of treatment of THP-1 cells when supplemented with a positive control, phorbol-12-myristate-13 acetate (PMA), as compared to PMA treatment alone.	Tetradecanoylphorbol Acetate	181-184	colony stimulating factor 2	Homo sapiens	0-6
2507555-6	1989	Therefore, we propose that there are two FGF-sensitive pathways in TA1 cells: one responsible for the initiation of differentiation (TPA sensitive) and another required for maintenance of the adipose phenotype (TPA insensitive).	Tetradecanoylphorbol Acetate	211-214	trace amine associated receptor 1	Homo sapiens	67-70
10551153-10	1999	GM-CSF (50 IU/ml) also significantly increased IL-8 production from 2-7 days of treatment of THP-1 cells when supplemented with a positive control, phorbol-12-myristate-13 acetate (PMA), as compared to PMA treatment alone.	Tetradecanoylphorbol Acetate	202-205	colony stimulating factor 2	Homo sapiens	0-6
2204815-6	1990	Expression of Oct-2 potentiated transcription 13-fold in response to TPA plus PHA and permitted the enhancer to respond to the single stimulus of TPA.	Tetradecanoylphorbol Acetate	69-72	POU class 2 homeobox 2	Homo sapiens	14-19
2204815-6	1990	Expression of Oct-2 potentiated transcription 13-fold in response to TPA plus PHA and permitted the enhancer to respond to the single stimulus of TPA.	Tetradecanoylphorbol Acetate	146-149	POU class 2 homeobox 2	Homo sapiens	14-19
10493498-6	1999	A single application of TPA and okadaic acid increased IL-1alpha and IL-1beta gene expression in TNF-/- mice.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 alpha	Mus musculus	55-64
2147467-6	1990	These studies demonstrate that the basic peptides of both Fos and Jun have higher affinity for the TPA responsive element (TRE) and the cAMP responsive element (CRE) relative to the corresponding peptide for CREB.	Tetradecanoylphorbol Acetate	99-102	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-61
2789262-3	1989	To investigate the regulation of TdT gene expression, pre-B and pre-T cells were treated with PMA or three of its analogs and its effects on steady-state TdT mRNA levels determined.	Tetradecanoylphorbol Acetate	94-97	DNA nucleotidylexotransferase	Homo sapiens	33-36
2789262-3	1989	To investigate the regulation of TdT gene expression, pre-B and pre-T cells were treated with PMA or three of its analogs and its effects on steady-state TdT mRNA levels determined.	Tetradecanoylphorbol Acetate	94-97	DNA nucleotidylexotransferase	Homo sapiens	154-157
10469612-13	1999	In summary, our data indicate that: (i) 79% of the BP/TPA skin tumors in CD-1 mice had c-Ha-ras mutations for the combined data for high dose and low dose tumors; (ii) the major mutations detected in BP/TPA skin tumors were G--&gt;T transversions; (iii) the global mutation profile in the c-Ha-ras proto-oncogene in skin tumors obtained after initiation with a low dose of BP was different from that obtained after initiation with a high dose of BP.	Tetradecanoylphorbol Acetate	54-57	POC1 centriolar protein A	Mus musculus	87-91
2594016-11	1989	However, CD4+ and CD8+ T cells produced large amounts of IL-2 when stimulated with mitogen and a protein kinase C activator, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	125-150	CD8a molecule	Homo sapiens	18-21
2594016-11	1989	However, CD4+ and CD8+ T cells produced large amounts of IL-2 when stimulated with mitogen and a protein kinase C activator, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	152-155	CD8a molecule	Homo sapiens	18-21
2288880-8	1990	Since the phorbol ester 12-O-tetradecanoylphorbol-13-acetate also decreases 125I-EGF binding and increases EGF receptor biosynthesis in GP6ac cells, we tested the effect of RA in cells depleted of protein kinase C by prolonged treatment (18 h) with 10 microM 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	24-60	epidermal growth factor receptor	Rattus norvegicus	107-119
10511314-1	1999	We have studied the regulation and role of c-Myc and Max in the differentiation pathways induced in K562 cells by 12-O-tetradecanoyl phorbol-13 acetate (TPA) and staurosporine, an activator and inhibitor, respectively, of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	114-151	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	43-48
2201557-0	1990	Effect of phorbol myristate acetate on c-myc, beta-actin, and FV gene expression in morphologically recognizable human megakaryocytes: a kinetic analysis employing in situ hybridization.	Tetradecanoylphorbol Acetate	10-35	POTE ankyrin domain family member F	Homo sapiens	46-64
2201557-7	1990	In contrast, after 2 h of exposure to 8 nM PMA, a statistically significant increase (p less than 0.001) in c-myc and beta-actin mRNA expression was observed, whereas FV mRNA expression appeared to be unchanged (p = 0.207).	Tetradecanoylphorbol Acetate	43-46	POTE ankyrin domain family member F	Homo sapiens	118-128
2506174-5	1989	A similar effect on tPA mRNA was observed, with phorbol myristate acetate inducing a 3.5-fold increase in steady state tPA mRNA levels and forskolin enhancing that increase to 25-fold.	Tetradecanoylphorbol Acetate	48-73	chromosome 20 open reading frame 181	Homo sapiens	20-23
10511314-4	1999	c-myc expression was down-regulated in K562 differentiated by both TPA and staurosporine, whereas max expression did not change in either case.	Tetradecanoylphorbol Acetate	67-70	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
2506174-5	1989	A similar effect on tPA mRNA was observed, with phorbol myristate acetate inducing a 3.5-fold increase in steady state tPA mRNA levels and forskolin enhancing that increase to 25-fold.	Tetradecanoylphorbol Acetate	48-73	chromosome 20 open reading frame 181	Homo sapiens	119-122
2201557-9	1990	However, in the presence of higher PMA doses (160 nM), beta-actin mRNA levels remained elevated at 24 h. The relationship between megakaryocyte maturation and apparent level of beta-actin mRNA expression was also examined.	Tetradecanoylphorbol Acetate	35-38	POTE ankyrin domain family member F	Homo sapiens	55-65
10487706-4	1999	Exposure of these cells, for 1 h, to the active phorbol ester, phorbol 12-myristate 13-acetate (TPA, 100 nmol/L), acting via protein kinase C (PKC), elicited an increase in MMP-1 mRNA, with a peak stimulation after a 3- to 4-h culture period.	Tetradecanoylphorbol Acetate	63-94	matrix metallopeptidase 1	Homo sapiens	173-178
2227262-7	1990	We presented results showing that DNA-protein complexes with a 23 bp DNA are similar to but distinct from those with a TPA-responsive element DNA, the recognition site for c-jun/fos products.	Tetradecanoylphorbol Acetate	119-122	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-177
2227262-7	1990	We presented results showing that DNA-protein complexes with a 23 bp DNA are similar to but distinct from those with a TPA-responsive element DNA, the recognition site for c-jun/fos products.	Tetradecanoylphorbol Acetate	119-122	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-181
2506451-1	1989	The TPA (12-O-tetradecanoyl-phorbol-13-acetate) responsive element (TRE) is recognized by the inducible transcription factor AP1, a heterodimeric complex of Fos- and Jun-protein subunits, which each contain a specific structure known as the leucine zipper through which they interact.	Tetradecanoylphorbol Acetate	4-7	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	125-128
2506451-1	1989	The TPA (12-O-tetradecanoyl-phorbol-13-acetate) responsive element (TRE) is recognized by the inducible transcription factor AP1, a heterodimeric complex of Fos- and Jun-protein subunits, which each contain a specific structure known as the leucine zipper through which they interact.	Tetradecanoylphorbol Acetate	4-7	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-160
2506451-1	1989	The TPA (12-O-tetradecanoyl-phorbol-13-acetate) responsive element (TRE) is recognized by the inducible transcription factor AP1, a heterodimeric complex of Fos- and Jun-protein subunits, which each contain a specific structure known as the leucine zipper through which they interact.	Tetradecanoylphorbol Acetate	9-46	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	125-128
10487706-4	1999	Exposure of these cells, for 1 h, to the active phorbol ester, phorbol 12-myristate 13-acetate (TPA, 100 nmol/L), acting via protein kinase C (PKC), elicited an increase in MMP-1 mRNA, with a peak stimulation after a 3- to 4-h culture period.	Tetradecanoylphorbol Acetate	96-99	matrix metallopeptidase 1	Homo sapiens	173-178
2506451-1	1989	The TPA (12-O-tetradecanoyl-phorbol-13-acetate) responsive element (TRE) is recognized by the inducible transcription factor AP1, a heterodimeric complex of Fos- and Jun-protein subunits, which each contain a specific structure known as the leucine zipper through which they interact.	Tetradecanoylphorbol Acetate	9-46	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-160
1973076-5	1990	In contrast, treatment of fibroblasts with the phorbol ester, TPA, stimulated ICAM-1-dependent adhesion without an increase in ICAM-1 surface expression.	Tetradecanoylphorbol Acetate	62-65	intercellular adhesion molecule 1	Homo sapiens	78-84
10487706-9	1999	TSH (10-500 microU/mL) failed to significantly influence basal MMP-1 or TIMP-1 mRNA levels, but it caused a dose-dependent inhibition in TPA- and EGF-induced MMP-1 mRNA in malignant cells, and TPA-stimulated MMP-1 and TIMP-1 in benign cells.	Tetradecanoylphorbol Acetate	137-140	matrix metallopeptidase 1	Homo sapiens	158-163
2369749-1	1990	Ornithine decarboxylase (ODC), the initial enzyme in the polyamine biosynthetic pathway, has been used as a marker for the hyperplasia that occurs following exposure of mouse epidermis to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	207-243	ornithine decarboxylase, structural 1	Mus musculus	0-23
10487706-9	1999	TSH (10-500 microU/mL) failed to significantly influence basal MMP-1 or TIMP-1 mRNA levels, but it caused a dose-dependent inhibition in TPA- and EGF-induced MMP-1 mRNA in malignant cells, and TPA-stimulated MMP-1 and TIMP-1 in benign cells.	Tetradecanoylphorbol Acetate	137-140	matrix metallopeptidase 1	Homo sapiens	158-163
2369749-1	1990	Ornithine decarboxylase (ODC), the initial enzyme in the polyamine biosynthetic pathway, has been used as a marker for the hyperplasia that occurs following exposure of mouse epidermis to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	207-243	ornithine decarboxylase, structural 1	Mus musculus	25-28
10487706-9	1999	TSH (10-500 microU/mL) failed to significantly influence basal MMP-1 or TIMP-1 mRNA levels, but it caused a dose-dependent inhibition in TPA- and EGF-induced MMP-1 mRNA in malignant cells, and TPA-stimulated MMP-1 and TIMP-1 in benign cells.	Tetradecanoylphorbol Acetate	193-196	matrix metallopeptidase 1	Homo sapiens	158-163
2369749-1	1990	Ornithine decarboxylase (ODC), the initial enzyme in the polyamine biosynthetic pathway, has been used as a marker for the hyperplasia that occurs following exposure of mouse epidermis to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	245-248	ornithine decarboxylase, structural 1	Mus musculus	0-23
2369749-1	1990	Ornithine decarboxylase (ODC), the initial enzyme in the polyamine biosynthetic pathway, has been used as a marker for the hyperplasia that occurs following exposure of mouse epidermis to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	245-248	ornithine decarboxylase, structural 1	Mus musculus	25-28
2369749-3	1990	Basal levels of ODC-specific antibody binding were detectable in acetone-treated CD-1 mouse epidermis and were increased 3-fold at 4 h after TPA treatment.	Tetradecanoylphorbol Acetate	141-144	ornithine decarboxylase, structural 1	Mus musculus	16-19
2369749-4	1990	The amount of ODC antibody binding detected after exposure to 17 nmol TPA twice weekly for 3 weeks was similar to that detected within cells isolated from papillomas and was 2.5-fold higher than in cells isolated at 4 h after a single topical treatment of mice with TPA.	Tetradecanoylphorbol Acetate	70-73	ornithine decarboxylase, structural 1	Mus musculus	14-17
2369749-4	1990	The amount of ODC antibody binding detected after exposure to 17 nmol TPA twice weekly for 3 weeks was similar to that detected within cells isolated from papillomas and was 2.5-fold higher than in cells isolated at 4 h after a single topical treatment of mice with TPA.	Tetradecanoylphorbol Acetate	266-269	ornithine decarboxylase, structural 1	Mus musculus	14-17
2369749-5	1990	These observations support the hypothesis that specific subpopulations of keratinocytes constitutively express high levels of ODC following chronic exposure to TPA.	Tetradecanoylphorbol Acetate	160-163	ornithine decarboxylase, structural 1	Mus musculus	126-129
2170146-4	1990	After activation of PKC by phorbol 12-myristate 13-acetate (PMA), CD45RA expression rapidly increased within the first 24 h, whereas CD45R0 expression did not change within this time.	Tetradecanoylphorbol Acetate	27-58	protein tyrosine phosphatase receptor type C	Homo sapiens	66-70
2503364-2	1989	These actions can be mimicked by pretreatment of lactotrophs with the protein kinase-C (PKC) activator 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	103-140	protein kinase C, gamma	Rattus norvegicus	70-86
2503364-2	1989	These actions can be mimicked by pretreatment of lactotrophs with the protein kinase-C (PKC) activator 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	103-140	protein kinase C, gamma	Rattus norvegicus	88-91
2547991-0	1989	Loss of responsiveness of an AP1-related factor, PEBP1, to 12-O-tetradecanoylphorbol-13-acetate after transformation of NIH 3T3 cells by the Ha-ras oncogene.	Tetradecanoylphorbol Acetate	59-95	phosphatidylethanolamine binding protein 1	Mus musculus	49-54
2170146-4	1990	After activation of PKC by phorbol 12-myristate 13-acetate (PMA), CD45RA expression rapidly increased within the first 24 h, whereas CD45R0 expression did not change within this time.	Tetradecanoylphorbol Acetate	60-63	protein tyrosine phosphatase receptor type C	Homo sapiens	66-70
10487706-9	1999	TSH (10-500 microU/mL) failed to significantly influence basal MMP-1 or TIMP-1 mRNA levels, but it caused a dose-dependent inhibition in TPA- and EGF-induced MMP-1 mRNA in malignant cells, and TPA-stimulated MMP-1 and TIMP-1 in benign cells.	Tetradecanoylphorbol Acetate	193-196	matrix metallopeptidase 1	Homo sapiens	158-163
2483582-4	1989	We observed TPA, like Buserelin, increased LH mRNA levels in a very similar manner, the alpha mRNA increasing 1.8 - 2.5 fold and the LH beta mRNA 1.4 - 1.7 fold after 5 h culture and 3.0 - 3.5 fold and 2.2 - 2.4 fold respectively, after 24 h. In the presence of cholera toxin, the changes were more rapid, the highest values being reached at 5 h (8.6 fold increase for alpha and 4.0 fold for LH beta mRNA).	Tetradecanoylphorbol Acetate	12-15	luteinizing hormone subunit beta	Homo sapiens	133-140
2483582-4	1989	We observed TPA, like Buserelin, increased LH mRNA levels in a very similar manner, the alpha mRNA increasing 1.8 - 2.5 fold and the LH beta mRNA 1.4 - 1.7 fold after 5 h culture and 3.0 - 3.5 fold and 2.2 - 2.4 fold respectively, after 24 h. In the presence of cholera toxin, the changes were more rapid, the highest values being reached at 5 h (8.6 fold increase for alpha and 4.0 fold for LH beta mRNA).	Tetradecanoylphorbol Acetate	12-15	luteinizing hormone subunit beta	Homo sapiens	392-399
2197329-2	1990	We showed previously that GM-CSF production by lectin or phorbol ester (12-O-tetradecanoyl-phorbol-13-acetate (TPA]-treated T cells was unaffected by cyclosporin A whereas IL-2 and IL-3 expression were.	Tetradecanoylphorbol Acetate	72-109	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	26-32
10496313-5	1999	In contrast, after in vitro stimulation of peripheral blood PMN with phorbol myristate acetate, CD66c was much less up-regulated compared with CD66a and CD66b.	Tetradecanoylphorbol Acetate	69-94	CEA cell adhesion molecule 6	Homo sapiens	96-101
2163316-10	1990	Pretreatment with PMA inhibited the subsequent response to 100 nM PMA and 100 microM dioctanoylglycerol, but not to 5 microM forskolin or to depolarization with 56 mM KCl, demonstrating specific down-regulation of PKC.	Tetradecanoylphorbol Acetate	18-21	protein kinase C, gamma	Rattus norvegicus	214-217
2526179-4	1989	CD4+CD45R+ cells produced high levels of IL-2 mRNA when stimulated with either PMA together with calcium ionophore, or with PHA, but they expressed only trace quantities of mRNA for IL-4 or IFN-gamma.	Tetradecanoylphorbol Acetate	79-82	protein tyrosine phosphatase receptor type C	Homo sapiens	4-9
2401859-7	1990	The role of GH is mediated, at least in part, by means of activation of protein kinase C. In the presence of 4-beta-phorbol-12-myristate 13-acetate (PMA), a parallel increase of LPL mRNA content and LPL activity is observed at half the values obtained upon stimulation by GH.	Tetradecanoylphorbol Acetate	109-147	lipoprotein lipase	Mus musculus	178-181
10496313-6	1999	All samples of synovial fluid PMN exhibited an additional increase in the expression of CD66a, CD66b, and CD66c when stimulated with phorbol myristate acetate in vitro.	Tetradecanoylphorbol Acetate	133-158	CEA cell adhesion molecule 6	Homo sapiens	106-111
2401859-7	1990	The role of GH is mediated, at least in part, by means of activation of protein kinase C. In the presence of 4-beta-phorbol-12-myristate 13-acetate (PMA), a parallel increase of LPL mRNA content and LPL activity is observed at half the values obtained upon stimulation by GH.	Tetradecanoylphorbol Acetate	109-147	lipoprotein lipase	Mus musculus	199-202
10475624-4	1999	Stimulation of HL-60 and MONO-MAC-6 with lipopolysaccharide (LPS), and stimulation of ML-2 and MUTZ-3 with 12-tetradecanoyl phorbol 13-acetate (TPA) dramatically increased the MCP-1 level in the culture medium.	Tetradecanoylphorbol Acetate	107-142	C-C motif chemokine ligand 2	Homo sapiens	176-181
2401859-7	1990	The role of GH is mediated, at least in part, by means of activation of protein kinase C. In the presence of 4-beta-phorbol-12-myristate 13-acetate (PMA), a parallel increase of LPL mRNA content and LPL activity is observed at half the values obtained upon stimulation by GH.	Tetradecanoylphorbol Acetate	149-152	lipoprotein lipase	Mus musculus	178-181
2401859-7	1990	The role of GH is mediated, at least in part, by means of activation of protein kinase C. In the presence of 4-beta-phorbol-12-myristate 13-acetate (PMA), a parallel increase of LPL mRNA content and LPL activity is observed at half the values obtained upon stimulation by GH.	Tetradecanoylphorbol Acetate	149-152	lipoprotein lipase	Mus musculus	199-202
2178224-5	1990	In addition, we show that IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate transiently induce c-jun and c-fos expression and that retinoic acid inhibits IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate induction of c-fos, but not c-jun.	Tetradecanoylphorbol Acetate	35-72	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	92-97
2178224-5	1990	In addition, we show that IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate transiently induce c-jun and c-fos expression and that retinoic acid inhibits IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate induction of c-fos, but not c-jun.	Tetradecanoylphorbol Acetate	35-72	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	102-107
2482920-4	1989	In this model, transgenic mice produce and secrete human tissue plasminogen activator (h.tPA) to which these mice are immunologically tolerant.	Tetradecanoylphorbol Acetate	89-92	chromosome 20 open reading frame 181	Homo sapiens	57-85
2677677-5	1989	When GM-CSF-deprived 32D clone 3 cells were exposed to GM-CSF or to TPA, four TIS mRNAs (TIS7, TIS8, TIS10, and TIS11) were rapidly and transiently induced.	Tetradecanoylphorbol Acetate	68-71	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	5-11
2677677-5	1989	When GM-CSF-deprived 32D clone 3 cells were exposed to GM-CSF or to TPA, four TIS mRNAs (TIS7, TIS8, TIS10, and TIS11) were rapidly and transiently induced.	Tetradecanoylphorbol Acetate	68-71	zinc finger protein 36	Mus musculus	112-117
2787934-3	1989	Exposure of human T cells and some mouse T cells to the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA), an activator of protein kinase C, caused the dissociation of p56lck and CD4.	Tetradecanoylphorbol Acetate	71-108	CD4 antigen	Mus musculus	188-191
2178224-5	1990	In addition, we show that IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate transiently induce c-jun and c-fos expression and that retinoic acid inhibits IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate induction of c-fos, but not c-jun.	Tetradecanoylphorbol Acetate	35-72	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	211-216
2178224-5	1990	In addition, we show that IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate transiently induce c-jun and c-fos expression and that retinoic acid inhibits IL-1 and 12-O-tetradecanoyl-phorbol-13-acetate induction of c-fos, but not c-jun.	Tetradecanoylphorbol Acetate	35-72	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	226-231
10475624-5	1999	The highest amount of MCP-1 (&gt; 80 ng/ml within 24 h) was achieved by TPA stimulation of MUTZ-3 cells.	Tetradecanoylphorbol Acetate	72-75	C-C motif chemokine ligand 2	Homo sapiens	22-27
10433227-6	1999	Treatment with PMA also facilitated LHRH-induced LH release, to approximately the same degree as NPY.	Tetradecanoylphorbol Acetate	15-18	gonadotropin releasing hormone 1	Rattus norvegicus	36-40
2119311-3	1990	These findings suggest that TPA stimulates PGE2 release through activation of protein kinase C, phospholipase A2 and the cyclooxygenase pathway.	Tetradecanoylphorbol Acetate	28-31	phospholipase A2, group IB, pancreas	Mus musculus	96-112
2160972-3	1990	The 3-kilobase edg-1 transcript is rapidly induced when endothelial cells are treated with PMA and superinduced in the presence of cycloheximide.	Tetradecanoylphorbol Acetate	91-94	sphingosine-1-phosphate receptor 1	Homo sapiens	15-20
2787934-3	1989	Exposure of human T cells and some mouse T cells to the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA), an activator of protein kinase C, caused the dissociation of p56lck and CD4.	Tetradecanoylphorbol Acetate	110-113	CD4 antigen	Mus musculus	188-191
2786455-4	1989	When GP6ac cells were treated with agents thought to regulate protein kinase C activity, e.g., the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), TGF-alpha mRNA levels increased by 8- to 11-fold.	Tetradecanoylphorbol Acetate	115-151	glycoprotein VI	Rattus norvegicus	5-8
2786455-4	1989	When GP6ac cells were treated with agents thought to regulate protein kinase C activity, e.g., the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), TGF-alpha mRNA levels increased by 8- to 11-fold.	Tetradecanoylphorbol Acetate	115-151	transforming growth factor alpha	Rattus norvegicus	159-168
10402232-7	1999	We recently demonstrated that the ability of substance P (SP) neuropeptide to activate MAP kinase pathway in U-373MG astrocytoma cells correlates with its ability to selectively translocate PKCepsilon from cytosolic to membrane fraction, and that PKC inhibitors (e.g. CGP 41251) inhibit the activation of this pathway by SP or the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	345-382	protein kinase C epsilon	Homo sapiens	190-200
2786455-7	1989	TPA also increased epidermal growth factor receptor mRNA in GP6ac cells but the effect was less prolonged; maximal levels were seen at 4 h after TPA exposure and returned to control levels by 12 h. TPA increased TGF-alpha mRNA in GP6ac cells, in part, by increasing transcription of the TGF-alpha gene as measured by run-on transcription rates in isolated nuclei.	Tetradecanoylphorbol Acetate	0-3	epidermal growth factor receptor	Rattus norvegicus	19-51
2786455-7	1989	TPA also increased epidermal growth factor receptor mRNA in GP6ac cells but the effect was less prolonged; maximal levels were seen at 4 h after TPA exposure and returned to control levels by 12 h. TPA increased TGF-alpha mRNA in GP6ac cells, in part, by increasing transcription of the TGF-alpha gene as measured by run-on transcription rates in isolated nuclei.	Tetradecanoylphorbol Acetate	0-3	transforming growth factor alpha	Rattus norvegicus	212-221
2786455-7	1989	TPA also increased epidermal growth factor receptor mRNA in GP6ac cells but the effect was less prolonged; maximal levels were seen at 4 h after TPA exposure and returned to control levels by 12 h. TPA increased TGF-alpha mRNA in GP6ac cells, in part, by increasing transcription of the TGF-alpha gene as measured by run-on transcription rates in isolated nuclei.	Tetradecanoylphorbol Acetate	0-3	transforming growth factor alpha	Rattus norvegicus	287-296
2786455-8	1989	In addition, the induction of TGF-alpha by TPA was blocked by concurrent incubation with agents that inhibit protein synthesis.	Tetradecanoylphorbol Acetate	43-46	transforming growth factor alpha	Rattus norvegicus	30-39
2166202-2	1990	Marked induction of c-fos mRNA in astrocytes was observed after treatment with epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), dibutyryl cyclic AMP (db-cAMP), and phorbol diester (TPA; 12-O-tetra-decanoylphorbol 13-acetate), which are known to induce the proliferation or differentiation of astrocytes.	Tetradecanoylphorbol Acetate	202-205	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	20-25
2166202-3	1990	Increase of c-fos protein immunoreactivity (IR) was obtained after treatment with fetal calf serum, EGF, bFGF, db-cAMP and TPA.	Tetradecanoylphorbol Acetate	123-126	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	12-17
10402232-7	1999	We recently demonstrated that the ability of substance P (SP) neuropeptide to activate MAP kinase pathway in U-373MG astrocytoma cells correlates with its ability to selectively translocate PKCepsilon from cytosolic to membrane fraction, and that PKC inhibitors (e.g. CGP 41251) inhibit the activation of this pathway by SP or the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	345-382	protein kinase C epsilon	Homo sapiens	190-193
2786455-11	1989	The time course of induction and the sensitivity to inhibition of protein synthesis distinguish the effect of TPA on TGF-alpha mRNA from that of other genes regulated by TPA, e.g., c-myc and c-fos.	Tetradecanoylphorbol Acetate	110-113	transforming growth factor alpha	Rattus norvegicus	117-126
2786455-11	1989	The time course of induction and the sensitivity to inhibition of protein synthesis distinguish the effect of TPA on TGF-alpha mRNA from that of other genes regulated by TPA, e.g., c-myc and c-fos.	Tetradecanoylphorbol Acetate	170-173	transforming growth factor alpha	Rattus norvegicus	117-126
2110502-2	1990	Incubation of leukemic cells in the presence of the phorbol esters, 12-O-tetradecanoyl-phorbol-13-acetate or phorbol 12,13-dibutyrate, resulted in reduction of ADA and TdT mRNA levels, while PNP mRNA levels increased under the same treatment.	Tetradecanoylphorbol Acetate	68-105	adenosine deaminase	Homo sapiens	160-163
10402232-7	1999	We recently demonstrated that the ability of substance P (SP) neuropeptide to activate MAP kinase pathway in U-373MG astrocytoma cells correlates with its ability to selectively translocate PKCepsilon from cytosolic to membrane fraction, and that PKC inhibitors (e.g. CGP 41251) inhibit the activation of this pathway by SP or the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	384-387	protein kinase C epsilon	Homo sapiens	190-200
2110502-2	1990	Incubation of leukemic cells in the presence of the phorbol esters, 12-O-tetradecanoyl-phorbol-13-acetate or phorbol 12,13-dibutyrate, resulted in reduction of ADA and TdT mRNA levels, while PNP mRNA levels increased under the same treatment.	Tetradecanoylphorbol Acetate	68-105	DNA nucleotidylexotransferase	Homo sapiens	168-171
2551669-6	1989	Despite the differences in c-myc induction in Raji(P207) and Raji(DE88) cells, c-fos and the early Epstein-Barr virus gene DR were induced to a similar extent and with similar kinetics by TPA.	Tetradecanoylphorbol Acetate	188-191	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-84
2110502-4	1990	TPA caused a 40% decrease in ADA and a 60% decrease in TdT enzyme activity, after 6 h of treatment.	Tetradecanoylphorbol Acetate	0-3	adenosine deaminase	Homo sapiens	29-32
2110502-4	1990	TPA caused a 40% decrease in ADA and a 60% decrease in TdT enzyme activity, after 6 h of treatment.	Tetradecanoylphorbol Acetate	0-3	DNA nucleotidylexotransferase	Homo sapiens	55-58
10402232-7	1999	We recently demonstrated that the ability of substance P (SP) neuropeptide to activate MAP kinase pathway in U-373MG astrocytoma cells correlates with its ability to selectively translocate PKCepsilon from cytosolic to membrane fraction, and that PKC inhibitors (e.g. CGP 41251) inhibit the activation of this pathway by SP or the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	384-387	protein kinase C epsilon	Homo sapiens	190-193
2112105-7	1990	A putative TRE (TPA responsive element or AP-1 recognition sequence) strategically situated upstream from the GST pi tsp (-69 to -63) was examined by TPA treatment of HeLa cells transfected with GST-cat DNA.	Tetradecanoylphorbol Acetate	150-153	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-46
10444661-6	1999	On the other hand, the attenuation of the mAHP induced by PKC activator phorbol 12-myristate 13-acetate was blocked almost completely by H89, suggesting that the PKC action on the mAHP requires PKA activation.	Tetradecanoylphorbol Acetate	72-103	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	194-197
2138520-0	1990	TPA induction of EL4 resistance to macrophage-released TNF: role of ADP-ribosylation in tumoricidal activities of TNF and other factors.	Tetradecanoylphorbol Acetate	0-3	epilepsy 4	Mus musculus	17-20
1971316-4	1990	However, after stimulation of the T cells with the combination of phorbol-12-myristate-13-acetate (PMA) and ionomycin to bypass CD3, 3 out of 6 old mice still exhibited 2-fold lower proliferative responses than T cells from young mice; IL-2 production by the CD4+ T cells was lower in all old mice tested.	Tetradecanoylphorbol Acetate	66-97	CD4 antigen	Mus musculus	259-262
2473135-0	1989	Conversion of xanthine dehydrogenase to xanthine oxidase occurs during keratinocyte differentiation: modulation by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	115-151	xanthine dehydrogenase	Mus musculus	14-36
2473135-0	1989	Conversion of xanthine dehydrogenase to xanthine oxidase occurs during keratinocyte differentiation: modulation by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	115-151	xanthine dehydrogenase	Mus musculus	40-56
2473135-5	1989	Total XD + XO and XO specific activities in each subpopulation derived from TPA-treated mice were approximately twice the values measured in their control counterparts.	Tetradecanoylphorbol Acetate	76-79	xanthine dehydrogenase	Mus musculus	6-8
1971316-4	1990	However, after stimulation of the T cells with the combination of phorbol-12-myristate-13-acetate (PMA) and ionomycin to bypass CD3, 3 out of 6 old mice still exhibited 2-fold lower proliferative responses than T cells from young mice; IL-2 production by the CD4+ T cells was lower in all old mice tested.	Tetradecanoylphorbol Acetate	99-102	CD4 antigen	Mus musculus	259-262
10459861-3	1999	Here we show by Northern blot analysis as well as by Western and ligand blotting that TPA strongly promotes activin betaA-subunit mRNA and activin A protein expression in K562 cells in time- and concentration dependent manner.	Tetradecanoylphorbol Acetate	86-89	inhibin subunit beta E	Homo sapiens	108-115
2473135-9	1989	Furthermore, the increases in XO activity measured in epidermal homogenates after TPA treatment are due to TPA-dependent increases in 1) the relative proportions of keratinocytes undergoing differentiation, 2) tissue XD content, and 3) increased conversion of XD to XO.	Tetradecanoylphorbol Acetate	82-85	xanthine dehydrogenase	Mus musculus	217-219
2473135-9	1989	Furthermore, the increases in XO activity measured in epidermal homogenates after TPA treatment are due to TPA-dependent increases in 1) the relative proportions of keratinocytes undergoing differentiation, 2) tissue XD content, and 3) increased conversion of XD to XO.	Tetradecanoylphorbol Acetate	82-85	xanthine dehydrogenase	Mus musculus	260-262
2473135-9	1989	Furthermore, the increases in XO activity measured in epidermal homogenates after TPA treatment are due to TPA-dependent increases in 1) the relative proportions of keratinocytes undergoing differentiation, 2) tissue XD content, and 3) increased conversion of XD to XO.	Tetradecanoylphorbol Acetate	107-110	xanthine dehydrogenase	Mus musculus	217-219
2473135-9	1989	Furthermore, the increases in XO activity measured in epidermal homogenates after TPA treatment are due to TPA-dependent increases in 1) the relative proportions of keratinocytes undergoing differentiation, 2) tissue XD content, and 3) increased conversion of XD to XO.	Tetradecanoylphorbol Acetate	107-110	xanthine dehydrogenase	Mus musculus	260-262
1692187-2	1990	In this fraction, basal gastrin release (mean +/- SE) was 31.1 +/- 1.3 pg.10(6) cells-1.60 min-1 and was stimulated by 10(-8) M neuromedin C (222.3 +/- 18.1% of basal), 10(-4) M carbachol (227.5 +/- 25.9%), 10(-6) M 12-O-tetradecanoylphorbol-13-acetate (TPA) (196.3 +/- 14.7%), and 10(-3) M dibutyryl adenosine 3",5"-cyclic monophosphate (DBcAMP) (193.9 +/- 6.8%), respectively.	Tetradecanoylphorbol Acetate	216-252	gastrin	Rattus norvegicus	24-31
10459861-3	1999	Here we show by Northern blot analysis as well as by Western and ligand blotting that TPA strongly promotes activin betaA-subunit mRNA and activin A protein expression in K562 cells in time- and concentration dependent manner.	Tetradecanoylphorbol Acetate	86-89	inhibin subunit beta E	Homo sapiens	139-146
1692187-2	1990	In this fraction, basal gastrin release (mean +/- SE) was 31.1 +/- 1.3 pg.10(6) cells-1.60 min-1 and was stimulated by 10(-8) M neuromedin C (222.3 +/- 18.1% of basal), 10(-4) M carbachol (227.5 +/- 25.9%), 10(-6) M 12-O-tetradecanoylphorbol-13-acetate (TPA) (196.3 +/- 14.7%), and 10(-3) M dibutyryl adenosine 3",5"-cyclic monophosphate (DBcAMP) (193.9 +/- 6.8%), respectively.	Tetradecanoylphorbol Acetate	254-257	gastrin	Rattus norvegicus	24-31
10459861-6	1999	(1994) Blood 83, 2163-2170), we now show that the activin type I and IB receptor mRNAs are clearly induced by TPA but not by activin or TGF-beta.	Tetradecanoylphorbol Acetate	110-113	inhibin subunit beta E	Homo sapiens	50-57
2333947-5	1990	The PKC antagonist H-7 dose dependently inhibited phorbol 12-myristate 13-acetate (TPA)-stimulated increases in 125I-ANG II binding, whereas downregulation of PKC activity by chronic phorbol ester incubations of 24 and 48 h prevented TPA-stimulated increases in 125I-ANG II-specific binding.	Tetradecanoylphorbol Acetate	50-81	protein kinase C, gamma	Rattus norvegicus	4-7
2333947-5	1990	The PKC antagonist H-7 dose dependently inhibited phorbol 12-myristate 13-acetate (TPA)-stimulated increases in 125I-ANG II binding, whereas downregulation of PKC activity by chronic phorbol ester incubations of 24 and 48 h prevented TPA-stimulated increases in 125I-ANG II-specific binding.	Tetradecanoylphorbol Acetate	83-86	protein kinase C, gamma	Rattus norvegicus	4-7
2797218-1	1989	(1) The effect of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a specific activator of the protein kinase C (PrkC), on the function of junctional nicotinic acetylcholine receptors (nAChR) was examined on muscle fibres isolated from the M. flexor digitorum brevis of the rat.	Tetradecanoylphorbol Acetate	36-72	protein kinase C, gamma	Rattus norvegicus	108-124
2797218-1	1989	(1) The effect of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a specific activator of the protein kinase C (PrkC), on the function of junctional nicotinic acetylcholine receptors (nAChR) was examined on muscle fibres isolated from the M. flexor digitorum brevis of the rat.	Tetradecanoylphorbol Acetate	36-72	protein kinase C, gamma	Rattus norvegicus	126-130
2333947-5	1990	The PKC antagonist H-7 dose dependently inhibited phorbol 12-myristate 13-acetate (TPA)-stimulated increases in 125I-ANG II binding, whereas downregulation of PKC activity by chronic phorbol ester incubations of 24 and 48 h prevented TPA-stimulated increases in 125I-ANG II-specific binding.	Tetradecanoylphorbol Acetate	83-86	protein kinase C, gamma	Rattus norvegicus	159-162
2333947-5	1990	The PKC antagonist H-7 dose dependently inhibited phorbol 12-myristate 13-acetate (TPA)-stimulated increases in 125I-ANG II binding, whereas downregulation of PKC activity by chronic phorbol ester incubations of 24 and 48 h prevented TPA-stimulated increases in 125I-ANG II-specific binding.	Tetradecanoylphorbol Acetate	234-237	protein kinase C, gamma	Rattus norvegicus	4-7
2333947-6	1990	TPA (0.8 microM), mezerein (0.76 microM), and teleocidin A (0.5 microM) all caused a rapid translocation of PKC activity from the cytosol to the particulate fraction by 15 min.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, gamma	Rattus norvegicus	108-111
2797218-1	1989	(1) The effect of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a specific activator of the protein kinase C (PrkC), on the function of junctional nicotinic acetylcholine receptors (nAChR) was examined on muscle fibres isolated from the M. flexor digitorum brevis of the rat.	Tetradecanoylphorbol Acetate	36-72	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	163-196
2797218-1	1989	(1) The effect of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a specific activator of the protein kinase C (PrkC), on the function of junctional nicotinic acetylcholine receptors (nAChR) was examined on muscle fibres isolated from the M. flexor digitorum brevis of the rat.	Tetradecanoylphorbol Acetate	36-72	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	198-203
10459861-7	1999	We also show that the inducing effect of TPA on expression of activin betaA-subunit mRNA is potentiated by the protein kinase A activator 8-bromo-cAMP.	Tetradecanoylphorbol Acetate	41-44	inhibin subunit beta E	Homo sapiens	62-69
10423169-1	1999	The operational equivalence of different types of tumor promoters was studied by comparing immediate, early, and late effects of okadaic acid (OA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) on the phosphorylation state of p42 mitogen-activated protein kinase isoform (ERK2) in eight different cell lines.	Tetradecanoylphorbol Acetate	151-187	cyclin dependent kinase 20	Homo sapiens	226-229
2797218-1	1989	(1) The effect of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a specific activator of the protein kinase C (PrkC), on the function of junctional nicotinic acetylcholine receptors (nAChR) was examined on muscle fibres isolated from the M. flexor digitorum brevis of the rat.	Tetradecanoylphorbol Acetate	74-77	protein kinase C, gamma	Rattus norvegicus	108-124
2797218-1	1989	(1) The effect of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a specific activator of the protein kinase C (PrkC), on the function of junctional nicotinic acetylcholine receptors (nAChR) was examined on muscle fibres isolated from the M. flexor digitorum brevis of the rat.	Tetradecanoylphorbol Acetate	74-77	protein kinase C, gamma	Rattus norvegicus	126-130
2111328-1	1990	Transcription factor AP-1 mediates induction of a set of genes in response to the phorbol ester tumor promoter TPA.	Tetradecanoylphorbol Acetate	111-114	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-25
10397697-6	1999	Activation of protein kinase C by phorbol-12-myristate-13-acetate (PMA) resulted in increased PAI-1 production, whereas activation of the cAMP-dependent protein kinase by forskolin or dibutyryl cAMP (dBu-cAMP) significantly decreased PAI-1 production.	Tetradecanoylphorbol Acetate	34-65	serpin family E member 1	Homo sapiens	94-99
2155220-10	1990	4 beta-Phorbol 12-myristate 13-acetate (PMA) treatment enhanced histamine-stimulated AA release and serotonin secretion but inhibited thrombin-stimulated reactions.	Tetradecanoylphorbol Acetate	0-38	prothrombin	Oryctolagus cuniculus	134-142
2155220-10	1990	4 beta-Phorbol 12-myristate 13-acetate (PMA) treatment enhanced histamine-stimulated AA release and serotonin secretion but inhibited thrombin-stimulated reactions.	Tetradecanoylphorbol Acetate	40-43	prothrombin	Oryctolagus cuniculus	134-142
2797218-1	1989	(1) The effect of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), a specific activator of the protein kinase C (PrkC), on the function of junctional nicotinic acetylcholine receptors (nAChR) was examined on muscle fibres isolated from the M. flexor digitorum brevis of the rat.	Tetradecanoylphorbol Acetate	74-77	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	163-196
2797218-3	1989	This effect was more pronounced as the TPA concentration was increased in the range of 0.1-1 microM and was blocked by the PrkC-inhibitor 1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine (H-7).	Tetradecanoylphorbol Acetate	39-42	protein kinase C, gamma	Rattus norvegicus	123-127
2797218-4	1989	(3) TPA (0.1-0.5 microM) shortly applied to patch-clamped fibres caused a slight decrease in nAChR-channel slope conductance without affecting the mean lifetime.	Tetradecanoylphorbol Acetate	4-7	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	93-98
2109710-7	1990	TPA-induced LH release was nearly abolished in PKC-depleted cells and the response to GnRH was markedly reduced (40%).	Tetradecanoylphorbol Acetate	0-3	protein kinase C, gamma	Rattus norvegicus	47-50
10397697-6	1999	Activation of protein kinase C by phorbol-12-myristate-13-acetate (PMA) resulted in increased PAI-1 production, whereas activation of the cAMP-dependent protein kinase by forskolin or dibutyryl cAMP (dBu-cAMP) significantly decreased PAI-1 production.	Tetradecanoylphorbol Acetate	67-70	serpin family E member 1	Homo sapiens	94-99
10397697-6	1999	Activation of protein kinase C by phorbol-12-myristate-13-acetate (PMA) resulted in increased PAI-1 production, whereas activation of the cAMP-dependent protein kinase by forskolin or dibutyryl cAMP (dBu-cAMP) significantly decreased PAI-1 production.	Tetradecanoylphorbol Acetate	67-70	serpin family E member 1	Homo sapiens	234-239
2469725-6	1989	Cross-linking class I MHC molecules on Jurkat cells induced a rise by [Ca2+]i and induced IL-2 production upon co-stimulation with PMA.	Tetradecanoylphorbol Acetate	131-134	major histocompatibility complex, class I, C	Homo sapiens	22-25
10403525-4	1999	Unexpectedly, pretreatment of cells with ara-C or dFdC opposed BRY- and PMA-related induction of the cyclin-dependent kinase inhibitors (CDKIs) p21CIP1 and/or p27KIP1.	Tetradecanoylphorbol Acetate	72-75	cyclin dependent kinase inhibitor 1B	Homo sapiens	159-166
2549949-4	1989	When protein kinase C was down-regulated by chronic TPA treatment, [Val-12]p21ras was no longer able to inhibit agonist-stimulated inositol phosphate production.	Tetradecanoylphorbol Acetate	52-55	Harvey rat sarcoma virus oncogene	Mus musculus	75-81
1690514-3	1990	Peak effects on c-fos mRNA occurred between 15 and 30 min and were completely gone after 2 h. The elevation in c-fos mRNA was, in part, dependent on protein kinase C, since phorbol myristate acetate (PMA) also elevated c-fos mRNA and further increased c-fos mRNA expression by endothelin, but the effects were not additive.	Tetradecanoylphorbol Acetate	200-203	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	111-116
10410976-7	1999	Polyclonal activation of lung T cells from OA/OA mice with 12-myristate 13-acetate (PMA), ionomycin, anti-CD3 mAb, and anti-CD28 mAb resulted in higher percentages of IL-2+ (43%) and IL-5+ (7%) CD4 cells when compared to CD4+ T cells from non-OA sensitized, challenged mice.	Tetradecanoylphorbol Acetate	84-87	interleukin 2	Mus musculus	167-171
2138160-2	1990	Phorbol 12-myristate 13-acetate (PMA) has been reported to induce maturation-like changes, including the loss of TdT, in many leukemic cell lines.	Tetradecanoylphorbol Acetate	0-31	DNA nucleotidylexotransferase	Homo sapiens	113-116
2138160-2	1990	Phorbol 12-myristate 13-acetate (PMA) has been reported to induce maturation-like changes, including the loss of TdT, in many leukemic cell lines.	Tetradecanoylphorbol Acetate	33-36	DNA nucleotidylexotransferase	Homo sapiens	113-116
2138160-4	1990	At a concentration of 8 nM, PMA caused both repression of TdT synthesis and arrest of proliferation.	Tetradecanoylphorbol Acetate	28-31	DNA nucleotidylexotransferase	Homo sapiens	58-61
2107492-4	1990	This, to our knowledge, is the first demonstration that it is possible, by using 2-aminopurine which selectively blocks TPA-stimulated pp33 phosphorylation, to block c-fos induction in TPA-treated cells although protein kinase C remains fully active.	Tetradecanoylphorbol Acetate	120-123	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	166-171
2107492-4	1990	This, to our knowledge, is the first demonstration that it is possible, by using 2-aminopurine which selectively blocks TPA-stimulated pp33 phosphorylation, to block c-fos induction in TPA-treated cells although protein kinase C remains fully active.	Tetradecanoylphorbol Acetate	185-188	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	166-171
2107492-5	1990	Further, we show here that although EGF- and TPA-stimulated induction of c-fos is abolished by 2-aminopurine, the appearance of TRE-binding activity in nuclear extracts of stimulated cells is unaffected, suggesting that EGF- and TPA-stimulated induction of TRE-binding activity utilises existing proteins and is not dependent on fresh c-FOS synthesis.	Tetradecanoylphorbol Acetate	45-48	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78
2107492-5	1990	Further, we show here that although EGF- and TPA-stimulated induction of c-fos is abolished by 2-aminopurine, the appearance of TRE-binding activity in nuclear extracts of stimulated cells is unaffected, suggesting that EGF- and TPA-stimulated induction of TRE-binding activity utilises existing proteins and is not dependent on fresh c-FOS synthesis.	Tetradecanoylphorbol Acetate	45-48	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	335-340
2541502-2	1989	Functional activation of the transacting transcription factor AP-1 by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) may play an essential role in this process.	Tetradecanoylphorbol Acetate	126-129	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	62-66
2706740-10	1989	After topical treatment with TPA, C57BL/6 demonstrated an unexpected 2- and 4-fold increase in ODC activity over CD-1 and DBA/2 mice.	Tetradecanoylphorbol Acetate	29-32	ornithine decarboxylase, structural 1	Mus musculus	95-98
2706740-12	1989	Thus, the resistant strain (C57BL/6) demonstrated a "hyperinducibility" of epidermal ODC activity by TPA or DiC8.	Tetradecanoylphorbol Acetate	101-104	ornithine decarboxylase, structural 1	Mus musculus	85-88
2107492-6	1990	These results imply that 2-aminopurine-sensitive complexed and chromatin-associated pp33 phosphorylation may be crucial to c-fos induction in response to EGF and TPA.	Tetradecanoylphorbol Acetate	162-165	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-128
10410976-7	1999	Polyclonal activation of lung T cells from OA/OA mice with 12-myristate 13-acetate (PMA), ionomycin, anti-CD3 mAb, and anti-CD28 mAb resulted in higher percentages of IL-2+ (43%) and IL-5+ (7%) CD4 cells when compared to CD4+ T cells from non-OA sensitized, challenged mice.	Tetradecanoylphorbol Acetate	84-87	interleukin 5	Mus musculus	183-187
2107494-0	1990	Cross-talk in signal transduction: TPA-inducible factor jun/AP-1 activates cAMP-responsive enhancer elements.	Tetradecanoylphorbol Acetate	35-38	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-64
2107494-3	1990	The fos/jun heterodimer binds to and activates transcription from TPA-responsive promoter elements (TGACTCA), which represent one final target of the protein kinase C pathway.	Tetradecanoylphorbol Acetate	66-69	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-7
10381655-4	1999	Treatment with PMA plus ionomycin (P/I) results in the upregulation of Fas Ligand (FasL) and induction of apoptosis.	Tetradecanoylphorbol Acetate	15-18	Fas ligand	Homo sapiens	71-81
2706741-4	1989	Chlordane (100 microM) stimulated mouse brain PKC activity in the 10(5) g supernatant to a maximum velocity equal to that obtained when the enzyme was maximally stimulated with the skin-tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	217-253	protein kinase C, gamma	Rattus norvegicus	46-49
2706741-4	1989	Chlordane (100 microM) stimulated mouse brain PKC activity in the 10(5) g supernatant to a maximum velocity equal to that obtained when the enzyme was maximally stimulated with the skin-tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	255-258	protein kinase C, gamma	Rattus norvegicus	46-49
2706741-7	1989	In contrast, the addition of calcium only minimally affected (less than 30% increase) the TPA-stimulated PKC activity.	Tetradecanoylphorbol Acetate	90-93	protein kinase C, gamma	Rattus norvegicus	105-108
2706741-8	1989	Concentrations of TPA and chlordane which maximally stimulate PKC did not produce an additive effect on PKC activity.	Tetradecanoylphorbol Acetate	18-21	protein kinase C, gamma	Rattus norvegicus	62-65
1689293-4	1990	The protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (PMA), is itself weakly mitogenic and synergises with CSF-1 for stimulation of BMM DNA synthesis suggesting a possible role for protein kinase C in the stimulation of BMM DNA synthesis.	Tetradecanoylphorbol Acetate	32-68	colony stimulating factor 1 (macrophage)	Mus musculus	123-128
1689293-4	1990	The protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (PMA), is itself weakly mitogenic and synergises with CSF-1 for stimulation of BMM DNA synthesis suggesting a possible role for protein kinase C in the stimulation of BMM DNA synthesis.	Tetradecanoylphorbol Acetate	70-73	colony stimulating factor 1 (macrophage)	Mus musculus	123-128
10381655-4	1999	Treatment with PMA plus ionomycin (P/I) results in the upregulation of Fas Ligand (FasL) and induction of apoptosis.	Tetradecanoylphorbol Acetate	15-18	Fas ligand	Homo sapiens	83-87
2706741-9	1989	Chlordane- and TPA- stimulated PKC activity was phospholipid-dependent and could be inhibited by quercetin, a known inhibitor of PKC activity.	Tetradecanoylphorbol Acetate	15-18	protein kinase C, gamma	Rattus norvegicus	31-34
10392899-3	1999	We have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases transcription of the MDR1 gene and activates the MDR1 promoter, and that promoter activation by TPA requires binding of the zinc finger transcription factor EGR1 to specific MDR1 promoter sequences (C. McCoy and M. M. Cornwell, Mol.	Tetradecanoylphorbol Acetate	64-67	early growth response 1	Homo sapiens	236-240
2706741-9	1989	Chlordane- and TPA- stimulated PKC activity was phospholipid-dependent and could be inhibited by quercetin, a known inhibitor of PKC activity.	Tetradecanoylphorbol Acetate	15-18	protein kinase C, gamma	Rattus norvegicus	129-132
2105883-1	1990	CD4, the T cell surface antigen, is phosphorylated and internalized when T cells are activated or treated with a phorbol ester, PMA.	Tetradecanoylphorbol Acetate	128-131	CD53 molecule	Homo sapiens	11-31
10392899-3	1999	We have demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases transcription of the MDR1 gene and activates the MDR1 promoter, and that promoter activation by TPA requires binding of the zinc finger transcription factor EGR1 to specific MDR1 promoter sequences (C. McCoy and M. M. Cornwell, Mol.	Tetradecanoylphorbol Acetate	175-178	early growth response 1	Homo sapiens	236-240
10392899-6	1999	We demonstrate here that the Wilms" tumor (WT) suppressor, WT1, a member of the EGR family, inhibits the response of the MDR1 promoter to TPA in K562 cells.	Tetradecanoylphorbol Acetate	138-141	early growth response 1	Homo sapiens	80-83
2111591-7	1990	We also demonstrate the down-regulation of the CD8 alpha/beta heterodimers from the surface of a CD8+ T-cell clone following treatment with phorbol myristate acetate (PMA) while CD8 alpha/alpha homodimers remain on the cell surface.	Tetradecanoylphorbol Acetate	140-165	CD8a molecule	Homo sapiens	47-56
11498991-2	1999	The results showed that 4-bromo calcium ionophore (A23187) and phorbol 12-myristate 13-acetate (PMA) enhanced significantly the TF expression of astrocytes, but the expression was decreased markedly by trifluoperazine (TFP) and 1-(5-isoquinolinyl sulfonyl)-3-methyl-piperazine (H7) in the basic medium.	Tetradecanoylphorbol Acetate	63-94	coagulation factor III, tissue factor	Homo sapiens	128-130
2111591-7	1990	We also demonstrate the down-regulation of the CD8 alpha/beta heterodimers from the surface of a CD8+ T-cell clone following treatment with phorbol myristate acetate (PMA) while CD8 alpha/alpha homodimers remain on the cell surface.	Tetradecanoylphorbol Acetate	140-165	CD8a molecule	Homo sapiens	47-50
2111591-7	1990	We also demonstrate the down-regulation of the CD8 alpha/beta heterodimers from the surface of a CD8+ T-cell clone following treatment with phorbol myristate acetate (PMA) while CD8 alpha/alpha homodimers remain on the cell surface.	Tetradecanoylphorbol Acetate	167-170	CD8a molecule	Homo sapiens	47-56
2111591-7	1990	We also demonstrate the down-regulation of the CD8 alpha/beta heterodimers from the surface of a CD8+ T-cell clone following treatment with phorbol myristate acetate (PMA) while CD8 alpha/alpha homodimers remain on the cell surface.	Tetradecanoylphorbol Acetate	167-170	CD8a molecule	Homo sapiens	47-50
2108866-4	1990	H-7 produced a shift to the right of the dose-response curve for the PKC activator, 12-o-tetradecanoylphorbol-13-acetate (TPA) in the case of SHR aortas, while no such shift was noted in tissues from WKY.	Tetradecanoylphorbol Acetate	84-120	solute carrier family 9 member A2	Rattus norvegicus	0-3
11498991-2	1999	The results showed that 4-bromo calcium ionophore (A23187) and phorbol 12-myristate 13-acetate (PMA) enhanced significantly the TF expression of astrocytes, but the expression was decreased markedly by trifluoperazine (TFP) and 1-(5-isoquinolinyl sulfonyl)-3-methyl-piperazine (H7) in the basic medium.	Tetradecanoylphorbol Acetate	96-99	coagulation factor III, tissue factor	Homo sapiens	128-130
10334914-4	1999	Only phorbol 12-myristate 13-acetate is a common inducer for HB-EGF mRNA.	Tetradecanoylphorbol Acetate	5-36	heparin binding EGF like growth factor	Homo sapiens	61-67
2153049-5	1990	This is in contrast to a rapid decrease in the expression of two other H-RS-cell-associated antigens, CD30 and 2H9, in all 12-O-tetradecanoyl phorbol-13-acetate-treated H-RS cells.	Tetradecanoylphorbol Acetate	123-160	TNF receptor superfamily member 8	Homo sapiens	102-106
2153119-5	1990	PMA induced an increase of cytochrome b558 in the plasma membrane, including the Mr 22,000 band.	Tetradecanoylphorbol Acetate	0-3	mitochondrially encoded cytochrome b	Homo sapiens	27-39
10320796-0	1999	A possible mechanism of TPA-mediated downregulation of neurotrophin-3 gene expression in rat cultured vascular smooth muscle cells.	Tetradecanoylphorbol Acetate	24-27	neurotrophin 3	Rattus norvegicus	55-69
10320796-1	1999	We have previously reported that in cultured rat vascular smooth muscle cells (VSMCs), neurotrophin-3 (NT-3) gene expression was suppressed by TPA (12-O-tetradecanoyl phorbol-13-acetate), which induces an AP-1 transcription factor.	Tetradecanoylphorbol Acetate	143-146	neurotrophin 3	Rattus norvegicus	87-101
10320796-1	1999	We have previously reported that in cultured rat vascular smooth muscle cells (VSMCs), neurotrophin-3 (NT-3) gene expression was suppressed by TPA (12-O-tetradecanoyl phorbol-13-acetate), which induces an AP-1 transcription factor.	Tetradecanoylphorbol Acetate	143-146	neurotrophin 3	Rattus norvegicus	103-107
10320796-1	1999	We have previously reported that in cultured rat vascular smooth muscle cells (VSMCs), neurotrophin-3 (NT-3) gene expression was suppressed by TPA (12-O-tetradecanoyl phorbol-13-acetate), which induces an AP-1 transcription factor.	Tetradecanoylphorbol Acetate	148-185	neurotrophin 3	Rattus norvegicus	87-101
1689117-10	1990	12-O-tetradecanoyl phorbol-13-acetate reproduced the action of carbachol on binding of N-[3H]methylscopolamine and 125I-CCK-8 but not on binding of 125I-[Tyr4]bombesin, suggesting that carbachol activation of protein kinase C may in some way mediate the effect of carbachol on receptors for carbachol and those for CCK but not that on receptors for bombesin.	Tetradecanoylphorbol Acetate	0-37	cholecystokinin	Cavia porcellus	120-123
10320796-1	1999	We have previously reported that in cultured rat vascular smooth muscle cells (VSMCs), neurotrophin-3 (NT-3) gene expression was suppressed by TPA (12-O-tetradecanoyl phorbol-13-acetate), which induces an AP-1 transcription factor.	Tetradecanoylphorbol Acetate	148-185	neurotrophin 3	Rattus norvegicus	103-107
1689117-10	1990	12-O-tetradecanoyl phorbol-13-acetate reproduced the action of carbachol on binding of N-[3H]methylscopolamine and 125I-CCK-8 but not on binding of 125I-[Tyr4]bombesin, suggesting that carbachol activation of protein kinase C may in some way mediate the effect of carbachol on receptors for carbachol and those for CCK but not that on receptors for bombesin.	Tetradecanoylphorbol Acetate	0-37	cholecystokinin	Cavia porcellus	315-318
10320796-2	1999	In the present study, to clarify the mechanism for TPA-mediated downregulation of NT-3 gene expression, effects of cycloheximide and dexamethasone (Dex) on the TPA-mediated downregulation were examined in VSMCs.	Tetradecanoylphorbol Acetate	51-54	neurotrophin 3	Rattus norvegicus	82-86
10320796-2	1999	In the present study, to clarify the mechanism for TPA-mediated downregulation of NT-3 gene expression, effects of cycloheximide and dexamethasone (Dex) on the TPA-mediated downregulation were examined in VSMCs.	Tetradecanoylphorbol Acetate	160-163	neurotrophin 3	Rattus norvegicus	82-86
10320796-3	1999	Pretreatment with cycloheximide, an inhibitor of protein synthesis, or simultaneous treatment with Dex, an inhibitor of AP-1, suppressed the TPA-mediated downregulation of NT-3 gene expression.	Tetradecanoylphorbol Acetate	141-144	neurotrophin 3	Rattus norvegicus	172-176
1966667-4	1990	The addition of phorbolmyristateacetate (PMA), a protein kinase C activator, also caused a biphasic change in beta 2-adrenoceptor density on the surface of the cells.	Tetradecanoylphorbol Acetate	16-39	adrenoceptor beta 2	Homo sapiens	110-129
1966667-4	1990	The addition of phorbolmyristateacetate (PMA), a protein kinase C activator, also caused a biphasic change in beta 2-adrenoceptor density on the surface of the cells.	Tetradecanoylphorbol Acetate	41-44	adrenoceptor beta 2	Homo sapiens	110-129
10320796-5	1999	The present findings suggest that TPA-induced AP-1 de novo synthesis causes the downregulation of NT-3 gene expression in VSMCs.	Tetradecanoylphorbol Acetate	34-37	neurotrophin 3	Rattus norvegicus	98-102
10376803-10	1999	With the use of immunofluorescence, annexin II was found to translocate from cytoplasm to plasma membranes in type II cells upon stimulation with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	146-177	annexin A2	Bos taurus	36-46
10363755-9	1999	After further adjustment for baseline insulin levels, leptin levels were in males significantly associated with increased waist circumference (P&lt;0.001), low HDL cholesterol (P&lt;0.05), low tPA activity (P&lt;0.01) and high PAI-1 activity (P&lt;0.001).	Tetradecanoylphorbol Acetate	193-196	leptin	Homo sapiens	54-60
2129501-1	1990	A cDNA encoding the human homolog of mouse T-cell and mast cell growth factor P40 was derived from peripheral blood mononuclear cells (PBMC) stimulated with phytohemagglutinin and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	180-205	interleukin 9	Mus musculus	78-81
2092039-8	1990	GM-1/P by itself was unable to stimulate IL-2 production; however it markedly increased IL-2 production induced by Con A or Con A plus TPA.	Tetradecanoylphorbol Acetate	135-138	coenzyme Q10A	Mus musculus	0-6
10363755-10	1999	In postmenopausal females, a significant association between leptin and low tPA activity/high PAI-1 activity was seen after adjustment for age and BMI (P&lt;0.05).	Tetradecanoylphorbol Acetate	76-79	leptin	Homo sapiens	61-67
10213915-2	1999	Exposure to stress-related alpha2- or beta-adrenergics for 4 or 20 h in vitro had no effect on apoptosis in splenocytes of adult Xenopus laevis, while a 4-hour coincubation of clonidine, an alpha2-agonist, with a calcium ionophore (A23187) or a phorbol diester (PMA), enhanced apoptosis induced by each apoptogen alone.	Tetradecanoylphorbol Acetate	262-265	MGC75582, possible similarity to act2 S homeolog	Xenopus laevis	27-33
2083235-1	1990	The upstream region of the mouse granulocyte macrophage colony stimulating factor (GM-CSF) gene between positions -95 and -73 is required for phorbol-12-myristate-13-acetate (PMA)- and calcium ionophore (A23187)-inducible transcriptional activity in vivo.	Tetradecanoylphorbol Acetate	142-173	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	33-81
2083235-1	1990	The upstream region of the mouse granulocyte macrophage colony stimulating factor (GM-CSF) gene between positions -95 and -73 is required for phorbol-12-myristate-13-acetate (PMA)- and calcium ionophore (A23187)-inducible transcriptional activity in vivo.	Tetradecanoylphorbol Acetate	142-173	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	83-89
2083235-1	1990	The upstream region of the mouse granulocyte macrophage colony stimulating factor (GM-CSF) gene between positions -95 and -73 is required for phorbol-12-myristate-13-acetate (PMA)- and calcium ionophore (A23187)-inducible transcriptional activity in vivo.	Tetradecanoylphorbol Acetate	175-178	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	33-81
2083235-1	1990	The upstream region of the mouse granulocyte macrophage colony stimulating factor (GM-CSF) gene between positions -95 and -73 is required for phorbol-12-myristate-13-acetate (PMA)- and calcium ionophore (A23187)-inducible transcriptional activity in vivo.	Tetradecanoylphorbol Acetate	175-178	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	83-89
11081197-5	1999	Treatment of primary cultures of pituitary adenomas with phorbol 12-myristrate 13-acetate (PMA) resulted in an increase in pancreastatin (PST) secretion in most pituitary adenomas and increased PC1 mRNA and protein expression in gonadotroph adenomas, but not in other types of adenomas.	Tetradecanoylphorbol Acetate	91-94	proprotein convertase subtilisin/kexin type 1	Homo sapiens	194-197
1688572-3	1990	FK-506 or CsA also inhibited proliferation, IL-2 production, and IL-2R expression in splenic T cells activated with ionomycin + PMA.	Tetradecanoylphorbol Acetate	128-131	interleukin 2 receptor, alpha chain	Mus musculus	65-70
10206975-4	1999	Whole-cell Kir2.3 currents were inhibited by phorbol 12-myristate 13-acetate (PMA) in Xenopus oocytes.	Tetradecanoylphorbol Acetate	45-76	potassium inwardly rectifying channel subfamily J member 4 S homeolog	Xenopus laevis	11-17
2294153-2	1990	Phorbol myristate acetate (TPA) had an augmenting effect on LPL secretion by in vitro-derived bone marrow macrophages (BMMs), thioglycollate-elicited peritoneal macrophages (TgM phi), and resistant macrophages.	Tetradecanoylphorbol Acetate	0-25	lipoprotein lipase	Mus musculus	60-63
2294153-2	1990	Phorbol myristate acetate (TPA) had an augmenting effect on LPL secretion by in vitro-derived bone marrow macrophages (BMMs), thioglycollate-elicited peritoneal macrophages (TgM phi), and resistant macrophages.	Tetradecanoylphorbol Acetate	27-30	lipoprotein lipase	Mus musculus	60-63
2294153-5	1990	L-cell conditioned medium (L-CM), a source of macrophage colony-stimulating activity, augmented LPL secretion by BMMs and Tg-M phi, and when added together with TPA had an additive augmenting effect on LPL secretion in these cells.	Tetradecanoylphorbol Acetate	161-164	lipoprotein lipase	Mus musculus	202-205
10206975-4	1999	Whole-cell Kir2.3 currents were inhibited by phorbol 12-myristate 13-acetate (PMA) in Xenopus oocytes.	Tetradecanoylphorbol Acetate	78-81	potassium inwardly rectifying channel subfamily J member 4 S homeolog	Xenopus laevis	11-17
2294153-9	1990	Thus, TPA and L-CM, agents that exert a mitogenic effect on BMMs and Tg-M phi, augmented the secretion of LPL in these cell types, and RA and dexamethasone, agents which induce differentiation patterns in myeloid cells, suppressed LPL secretion.	Tetradecanoylphorbol Acetate	6-9	lipoprotein lipase	Mus musculus	106-109
10198352-3	1999	MUC5AC mRNA levels increased after &gt;/=0.01 nM acrolein, 10 microM prostaglandin E2 or 15-hydroxyeicosatetraenoic acid, 1.0 nM tumor necrosis factor-alpha (TNF-alpha), or 10 nM phorbol 12-myristate 13-acetate (a protein kinase C activator).	Tetradecanoylphorbol Acetate	179-210	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	0-6
2294153-9	1990	Thus, TPA and L-CM, agents that exert a mitogenic effect on BMMs and Tg-M phi, augmented the secretion of LPL in these cell types, and RA and dexamethasone, agents which induce differentiation patterns in myeloid cells, suppressed LPL secretion.	Tetradecanoylphorbol Acetate	6-9	lipoprotein lipase	Mus musculus	231-234
10209301-3	1999	While phorbol 12-myristate 13-acetate (PMA) upregulated the PAI-1 mRNA expression, a calcium ionophore, ionomycin, had little effect.	Tetradecanoylphorbol Acetate	6-37	serpin family E member 2	Rattus norvegicus	60-65
10209301-3	1999	While phorbol 12-myristate 13-acetate (PMA) upregulated the PAI-1 mRNA expression, a calcium ionophore, ionomycin, had little effect.	Tetradecanoylphorbol Acetate	39-42	serpin family E member 2	Rattus norvegicus	60-65
10051662-4	1999	Neurotoxicity elicited by hydrogen peroxide in hippocampal and cortical neuronal cultures is prevented by the phorbol ester, phorbol 12-myristate 13-acetate (PMA) via stimulation of protein kinase C. We observe phosphorylation of HO2 through the protein kinase C pathway with enhancement of HO2 catalytic activity and accumulation of BR in neuronal cultures.	Tetradecanoylphorbol Acetate	125-156	heme oxygenase 2	Mus musculus	230-233
2136708-7	1990	Furthermore, the level of this factor was found to increase to even higher levels in CREF cells treated with 12-O-tetradecanoylphorbol-13-acetate, and this induction resulted in a further suppression in the rate of E1A gene transcription.	Tetradecanoylphorbol Acetate	109-145	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	215-218
2222808-2	1990	In combination with 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent activator of PKC, TNF-alpha caused marked growth inhibition of LoVo cells, but TNF-beta had little antiproliferative effect.	Tetradecanoylphorbol Acetate	58-61	lymphotoxin alpha	Homo sapiens	152-160
2785861-6	1989	In addition, IL-4 in combination with PMA produced a marked increase in IgM secretion by peritoneal B cells cultured in vitro.	Tetradecanoylphorbol Acetate	38-41	immunoglobulin heavy constant mu	Mus musculus	72-75
10051662-4	1999	Neurotoxicity elicited by hydrogen peroxide in hippocampal and cortical neuronal cultures is prevented by the phorbol ester, phorbol 12-myristate 13-acetate (PMA) via stimulation of protein kinase C. We observe phosphorylation of HO2 through the protein kinase C pathway with enhancement of HO2 catalytic activity and accumulation of BR in neuronal cultures.	Tetradecanoylphorbol Acetate	125-156	heme oxygenase 2	Mus musculus	291-294
10051662-4	1999	Neurotoxicity elicited by hydrogen peroxide in hippocampal and cortical neuronal cultures is prevented by the phorbol ester, phorbol 12-myristate 13-acetate (PMA) via stimulation of protein kinase C. We observe phosphorylation of HO2 through the protein kinase C pathway with enhancement of HO2 catalytic activity and accumulation of BR in neuronal cultures.	Tetradecanoylphorbol Acetate	158-161	heme oxygenase 2	Mus musculus	230-233
2501508-2	1989	Induction of c-fos by epidermal growth factor, A23187, dBcAMP, or TPA in the same cells is not affected.	Tetradecanoylphorbol Acetate	66-69	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-18
10051662-4	1999	Neurotoxicity elicited by hydrogen peroxide in hippocampal and cortical neuronal cultures is prevented by the phorbol ester, phorbol 12-myristate 13-acetate (PMA) via stimulation of protein kinase C. We observe phosphorylation of HO2 through the protein kinase C pathway with enhancement of HO2 catalytic activity and accumulation of BR in neuronal cultures.	Tetradecanoylphorbol Acetate	158-161	heme oxygenase 2	Mus musculus	291-294
33801658-7	2021	RESULTS: The two sphingosine-1-phosphate receptors (S1PRs) expressed in peritoneal B cell subsets S1P1 and S1P4 are differentially regulated upon stimulation with the TLR4 agonist LPS, but not upon PMA/ionomycin or B cell receptor (BCR) crosslinking.	Tetradecanoylphorbol Acetate	198-201	sphingosine-1-phosphate receptor 1	Homo sapiens	98-102
10051662-5	1999	The neuroprotective effects of PMA are prevented by the HO inhibitor tin protoporphyrin IX and in cultures from mice with deletion of HO2 gene.	Tetradecanoylphorbol Acetate	31-34	heme oxygenase 2	Mus musculus	134-137
10049506-7	1999	Interestingly, although PKC-alpha also mediates the stimulatory effect of PMA on the synthesis of PtdCho by a phosphorylation mechanism, overexpression of holo PKC-epsilon or its regulatory domain fragments did not affect PMA-induced PtdCho synthesis.	Tetradecanoylphorbol Acetate	74-77	protein kinase C epsilon	Homo sapiens	160-171
10049654-5	1999	These data are strengthened by the observation that PMA and dibutyryl cGMP, but not A23187, increased P-selectin expression.	Tetradecanoylphorbol Acetate	52-55	selectin P	Homo sapiens	102-112
33237422-8	2021	PMA induced the MAPK pathway in HeLa cells through the activation of ERK, CREB, and RSK1.	Tetradecanoylphorbol Acetate	0-3	cAMP responsive element binding protein 1	Homo sapiens	74-78
33824670-3	2020	Accordingly, the objective of this study was to investigate the in vitro effects of trans-palmitoleic acid (tPA) and palmitic acid (PA) on lipid accumulation in hepatocytes, focusing on the gene expression of sirtuin 1 (SIRT1) as well as the transcriptional activity of peroxisome proliferator-activated receptor alpha (PPARalpha).	Tetradecanoylphorbol Acetate	108-111	sirtuin 1	Homo sapiens	209-218
33824670-12	2020	Conclusion: tPA causes less lipid accumulation in hepatocytes with no detrimental effect on cell viability and might be beneficial for liver cells by the activation of SIRT1 and induction of PPARalpha activity.	Tetradecanoylphorbol Acetate	12-15	sirtuin 1	Homo sapiens	168-173
2753224-1	1989	Recently, the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) was found to have prolactin (PRL)-like actions on specific metabolic processes in mouse mammary gland explants.	Tetradecanoylphorbol Acetate	47-83	prolactin	Mus musculus	108-117
2753224-1	1989	Recently, the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) was found to have prolactin (PRL)-like actions on specific metabolic processes in mouse mammary gland explants.	Tetradecanoylphorbol Acetate	85-88	prolactin	Mus musculus	108-117
10049654-6	1999	WEB 2086 (10 microM), a PAF-receptor antagonist, blocked peroxide-, PMA-, and A23187-mediated adhesion, but not peroxide-mediated P-selectin expression.	Tetradecanoylphorbol Acetate	68-71	PCNA clamp associated factor	Homo sapiens	24-27
7669726-7	1995	Staurosporine and H7, however, inhibit the increase in c-jun mRNA by TPA.	Tetradecanoylphorbol Acetate	69-72	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-60
9932870-0	1999	Effect of TPA on aquaporin 4 mRNA expression in cultured rat astrocytes.	Tetradecanoylphorbol Acetate	10-13	aquaporin 4	Rattus norvegicus	17-28
8070351-4	1994	In VSMC, angiotensin-II, which induces PTHrP expression, also rapidly (30 min) desensitized the cAMP response and down-regulated (75-90%) receptor mRNA within 1 h. Treatment of cells with phorbol 12-myristate 13-acetate (0.1 microM) mimicked these effects, whereas neither PTHrP-(1-34)NH2, forskolin, nor (Bu)2cAMP altered receptor mRNA expression.	Tetradecanoylphorbol Acetate	188-219	parathyroid hormone-like hormone	Rattus norvegicus	39-44
8070351-4	1994	In VSMC, angiotensin-II, which induces PTHrP expression, also rapidly (30 min) desensitized the cAMP response and down-regulated (75-90%) receptor mRNA within 1 h. Treatment of cells with phorbol 12-myristate 13-acetate (0.1 microM) mimicked these effects, whereas neither PTHrP-(1-34)NH2, forskolin, nor (Bu)2cAMP altered receptor mRNA expression.	Tetradecanoylphorbol Acetate	188-219	parathyroid hormone-like hormone	Rattus norvegicus	273-278
2542778-7	1989	These results demonstrate that intracellular cAMP and TPA are potent activators of both alpha- and LH beta-polypeptide chain synthesis, suggesting that cAMP as well as diacylglycerols may act as intracellular mediators of the GnRH effect on LH subunit synthesis.	Tetradecanoylphorbol Acetate	54-57	luteinizing hormone subunit beta	Homo sapiens	99-106
9932870-5	1999	Treatment of the cells with 0.1 microM of phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), an activator of PKC, caused a rapid decrease in AQP4 mRNA.	Tetradecanoylphorbol Acetate	56-92	aquaporin 4	Rattus norvegicus	148-152
9932870-5	1999	Treatment of the cells with 0.1 microM of phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), an activator of PKC, caused a rapid decrease in AQP4 mRNA.	Tetradecanoylphorbol Acetate	94-97	aquaporin 4	Rattus norvegicus	148-152
34436652-8	2021	In HT29 cells, phorbol 12-myristate 13-acetate (PMA) induced COX-2 expression and increased CD44 and ICAM-1 levels were down-regulated by diclofenac.	Tetradecanoylphorbol Acetate	15-46	CD44 molecule (Indian blood group)	Homo sapiens	92-96
9932870-7	1999	The TPA-induced decrease in AQP4 mRNA was inhibited by a relatively specific PKC inhibitor, 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H7) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	4-7	aquaporin 4	Rattus norvegicus	28-32
34436652-8	2021	In HT29 cells, phorbol 12-myristate 13-acetate (PMA) induced COX-2 expression and increased CD44 and ICAM-1 levels were down-regulated by diclofenac.	Tetradecanoylphorbol Acetate	15-46	intercellular adhesion molecule 1	Homo sapiens	101-107
2538838-3	1989	Two protein kinase C activators, 1,2-dioctanoyl glycerol and phorbol 12-myristate 13-acetate, suppress, whereas the calcium ionophore ionomycin enhances, the IFN-alpha/beta-induced expression of 2",5"-OAS mRNA.	Tetradecanoylphorbol Acetate	61-92	interferon alpha	Mus musculus	158-167
34436652-8	2021	In HT29 cells, phorbol 12-myristate 13-acetate (PMA) induced COX-2 expression and increased CD44 and ICAM-1 levels were down-regulated by diclofenac.	Tetradecanoylphorbol Acetate	48-51	CD44 molecule (Indian blood group)	Homo sapiens	92-96
9932870-8	1999	Moreover, prolonged treatment of the cells with TPA eliminated the subsequent decrease in AQP4 mRNA by TPA.	Tetradecanoylphorbol Acetate	48-51	aquaporin 4	Rattus norvegicus	90-94
34436652-8	2021	In HT29 cells, phorbol 12-myristate 13-acetate (PMA) induced COX-2 expression and increased CD44 and ICAM-1 levels were down-regulated by diclofenac.	Tetradecanoylphorbol Acetate	48-51	intercellular adhesion molecule 1	Homo sapiens	101-107
9932870-8	1999	Moreover, prolonged treatment of the cells with TPA eliminated the subsequent decrease in AQP4 mRNA by TPA.	Tetradecanoylphorbol Acetate	103-106	aquaporin 4	Rattus norvegicus	90-94
9932870-9	1999	These results strongly suggest that the TPA-induced decrease in AQP4 mRNA is mediated by PKC activation.	Tetradecanoylphorbol Acetate	40-43	aquaporin 4	Rattus norvegicus	64-68
9932870-12	1999	To test whether the TPA-induced decrease in AQP4 was due to a decrease in the mRNA stability, we examined the effect of actinomycin D, an inhibitor of transcription, on TPA-treated cells.	Tetradecanoylphorbol Acetate	20-23	aquaporin 4	Rattus norvegicus	44-48
2648396-7	1989	Furthermore, formation of foci of transformed RECs by the c-jun/ras combination was augmented 3-fold by the tumor promoter phorbol 12-tetradecanoate 13-acetate.	Tetradecanoylphorbol Acetate	123-159	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-63
34536821-8	2021	Phorbol 12-myristate 13-acetate (PMA) and lipopolysaccharide (LPS), the agonists of PKC and NF-kappaB signaling, respectively, significantly inhibit hp65-mediated UGT1A1 luciferase activity.	Tetradecanoylphorbol Acetate	0-31	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	163-169
9932870-14	1999	The results suggest that AQP4 mRNA is inhibited by TPA via PKC activation without de novo protein synthesis, and that the inhibition of AQP4 mRNA could be at the transcriptional level.	Tetradecanoylphorbol Acetate	51-54	aquaporin 4	Rattus norvegicus	25-29
34536821-8	2021	Phorbol 12-myristate 13-acetate (PMA) and lipopolysaccharide (LPS), the agonists of PKC and NF-kappaB signaling, respectively, significantly inhibit hp65-mediated UGT1A1 luciferase activity.	Tetradecanoylphorbol Acetate	33-36	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	163-169
9917510-9	1999	In brief, we have demonstrated that the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA)-induced luciferase activity in this cell system is mediated via the MAP kinase pathway and can be blocked in the presence of MEK1 selective inhibitors (PD 098059 or U0126).	Tetradecanoylphorbol Acetate	54-91	mitogen-activated protein kinase kinase 1	Homo sapiens	223-227
34536821-10	2021	PMA and LPS do not affect UGT1A1 activity in p65-silenced HepG2 cells; however, UA and OA mildly influence UGT1A1 expression in these cells.	Tetradecanoylphorbol Acetate	0-3	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	107-113
34437989-5	2021	The effect of PMA treatment was assayed on cell viability, caspase 3 activation, TNF-alpha and IL-1beta release and TNF receptor type I (TNFRI) and TNF receptor type II (TNFRII) levels.	Tetradecanoylphorbol Acetate	14-17	TNF receptor superfamily member 1A	Rattus norvegicus	116-135
34437989-5	2021	The effect of PMA treatment was assayed on cell viability, caspase 3 activation, TNF-alpha and IL-1beta release and TNF receptor type I (TNFRI) and TNF receptor type II (TNFRII) levels.	Tetradecanoylphorbol Acetate	14-17	TNF receptor superfamily member 1A	Rattus norvegicus	137-142
34437989-8	2021	PMA treatment also induces an increase in TNFRII levels while decreasing TNFRI after 24h.	Tetradecanoylphorbol Acetate	0-3	TNF receptor superfamily member 1A	Rattus norvegicus	73-78
2567568-11	1989	These results indicate that in the TPA-induced ear inflammation model the MPO response at 24 hr may be a useful additional indicator of drug activity.	Tetradecanoylphorbol Acetate	35-38	myeloperoxidase	Mus musculus	74-77
2466408-4	1989	In the presence of EGTA, 100 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) significantly increased ANP secretion; this increment was unaffected by 100 microM ryanodine.	Tetradecanoylphorbol Acetate	32-68	natriuretic peptide A	Rattus norvegicus	99-102
2466408-4	1989	In the presence of EGTA, 100 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) significantly increased ANP secretion; this increment was unaffected by 100 microM ryanodine.	Tetradecanoylphorbol Acetate	70-73	natriuretic peptide A	Rattus norvegicus	99-102
34671340-5	2021	As a functional outcome, immobilized FH and FHR-1 inhibited PMA-induced NET formation, but increased the adherence and IL-8 production of neutrophils.	Tetradecanoylphorbol Acetate	60-63	complement factor H	Homo sapiens	37-39
9917510-9	1999	In brief, we have demonstrated that the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA)-induced luciferase activity in this cell system is mediated via the MAP kinase pathway and can be blocked in the presence of MEK1 selective inhibitors (PD 098059 or U0126).	Tetradecanoylphorbol Acetate	93-96	mitogen-activated protein kinase kinase 1	Homo sapiens	223-227
10096423-0	1999	Inhibition of TPA-induced tumor promotion in CD-1 mouse epidermis by a polyphenolic fraction from grape seeds.	Tetradecanoylphorbol Acetate	14-17	CD1 antigen complex	Mus musculus	45-49
34157522-8	2021	A remarkable relationship was observed between the modified Rankin Score (mRS) and IL-38 serum changes in response to tPA therapy (P < 0.001).	Tetradecanoylphorbol Acetate	118-121	interleukin 1 family member 10	Homo sapiens	83-88
34157522-9	2021	Besides, IL-38 serum changes following tPA were dramatically related to NIHSS at hospitalization (P = 0.007).	Tetradecanoylphorbol Acetate	39-42	interleukin 1 family member 10	Homo sapiens	9-14
34157522-13	2021	CONCLUSION: The results indicate that tPA could meaningfully increase the IL-38 serum level.	Tetradecanoylphorbol Acetate	38-41	interleukin 1 family member 10	Homo sapiens	74-79
34157522-14	2021	Also, a negative correlation has been found between IL-38 serum changes in response to tPA and mRS.	Tetradecanoylphorbol Acetate	87-90	interleukin 1 family member 10	Homo sapiens	52-57
2466408-5	1989	These experiments suggest 1) that in absence of contractions, ANP secretion requires neither transplasmalemmal Ca2+ influx nor ryanodine-inhibitable Ca2+ release by sarcoplasmic reticulum (SR) and 2) that TPA stimulates ANP secretion without requiring Ca influx or ryanodine-inhibitable SR Ca release.	Tetradecanoylphorbol Acetate	205-208	natriuretic peptide A	Rattus norvegicus	62-65
9880563-2	1999	The MCL1 member of the BCL2 family is up-regulated during the induction of monocytic differentiation (approximately 10-fold with 12-O-tetradecanoylphorbol 13-acetate (TPA)).	Tetradecanoylphorbol Acetate	129-165	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	4-8
2496135-2	1989	This study describes the ability of TPA to also alter calcium ionophore A23187-induced incorporation of [3H]acetate into platelet activating factor (PAF).	Tetradecanoylphorbol Acetate	36-39	patchy fur	Mus musculus	149-152
2496135-5	1989	Sequential exposure to TPA and A23187 resulted in a greatly enhanced incorporation (11,861 dpm/10(6) cells) of [3H]acetate into PAF compared to TPA alone, which did not significantly influence [3H]acetate incorporation into PAF, and 0.1 microM A23187, which induced minimal incorporation (688 dpm/10(6) cells).	Tetradecanoylphorbol Acetate	23-26	patchy fur	Mus musculus	128-131
2496135-5	1989	Sequential exposure to TPA and A23187 resulted in a greatly enhanced incorporation (11,861 dpm/10(6) cells) of [3H]acetate into PAF compared to TPA alone, which did not significantly influence [3H]acetate incorporation into PAF, and 0.1 microM A23187, which induced minimal incorporation (688 dpm/10(6) cells).	Tetradecanoylphorbol Acetate	23-26	patchy fur	Mus musculus	224-227
34572313-9	2021	We found that human monomeric IgG and its subclasses IgG1 and IgG2 per se induced negligible NET formation of dHL-60, but the FcgammaRIII engagement by these IgG subclasses and Fc portion augment PMA-stimulated dHL-60 NET formation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	196-199	Fc gamma receptor IIIa	Homo sapiens	126-137
34572313-12	2021	In conclusion, we discovered that cross-talk between FcgammaRIII engagement-induced Syk-ERK and PMA-induced PKC signaling pathways augment NET formation of dHL-60 via increased ROS generation and pro-inflammatory cytokines, IL-8 and TNF-alpha, production.	Tetradecanoylphorbol Acetate	96-99	Fc gamma receptor IIIa	Homo sapiens	53-64
9880563-2	1999	The MCL1 member of the BCL2 family is up-regulated during the induction of monocytic differentiation (approximately 10-fold with 12-O-tetradecanoylphorbol 13-acetate (TPA)).	Tetradecanoylphorbol Acetate	167-170	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	4-8
34591419-11	2021	However, treatment with phorbol myristate acetate stimulated the expression of MMP-9, both active and inactive forms in equal proportion.	Tetradecanoylphorbol Acetate	24-49	matrix metallopeptidase 9	Homo sapiens	79-84
9880563-7	1999	Thus, the mechanism of the TPA-induced increase in MCL1 expression seen in myelomonocytic cells at early stages of differentiation involves signal transduction through ERKs and transcriptional activation through SRF/Elk-1.	Tetradecanoylphorbol Acetate	27-30	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	51-55
2644975-3	1989	In addition, sodium orthovanadate, an inhibitor of phosphotyrosine phosphatase, and 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a known activator of protein kinase C, also stimulated DNA synthesis in these cells, suggesting that protein phosphorylation might be involved in the mechanism of action of mIL-3 and mGM-CSF.	Tetradecanoylphorbol Acetate	84-121	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	312-319
10599442-3	1999	PURPOSE: The purpose of this study is to determine whether u-PAR display in 4 human bladder cancer cell lines (RT4, 253J, EJ and T24) can be modulated with substances including phorbol 12-myristate 13-acetate, interferon gamma, epidermal growth factor, and transforming growth factor beta and to correlate changes with u-PAR expression with the ability of these cells to invade artificial basement membrane (Matrigel).	Tetradecanoylphorbol Acetate	177-208	plasminogen activator, urokinase receptor	Homo sapiens	59-64
2522880-4	1989	In the presence of the tumor promoter phorbol 12-myristate 13-acetate IL 1 augments IL 2 secretion and IL 2R expression of EL4 5D3 but not of EL4 D6/76 cells.	Tetradecanoylphorbol Acetate	38-69	interleukin 2 receptor, alpha chain	Mus musculus	103-108
2522880-4	1989	In the presence of the tumor promoter phorbol 12-myristate 13-acetate IL 1 augments IL 2 secretion and IL 2R expression of EL4 5D3 but not of EL4 D6/76 cells.	Tetradecanoylphorbol Acetate	38-69	epilepsy 4	Mus musculus	123-126
2783435-6	1989	PMA could induce CD4 and CD8 phosphorylation in both CD3L and CD3H fractions.	Tetradecanoylphorbol Acetate	0-3	CD8a molecule	Homo sapiens	25-28
2646299-1	1989	Macrophage activation activity was characterized from a PMA-induced subclone of the murine EL-4 leukaemic cell line.	Tetradecanoylphorbol Acetate	56-59	epilepsy 4	Mus musculus	91-95
2498558-4	1989	Lipoxygenase inhibitors also inhibited TPA-caused ODC induction in isolated epidermal cells or cultured epidermal cells.	Tetradecanoylphorbol Acetate	39-42	ornithine decarboxylase, structural 1	Mus musculus	50-53
2498558-5	1989	Therefore, it is possible that these drugs inhibit TPA-caused ODC induction in mouse skin by directly acting on epidermal cells.	Tetradecanoylphorbol Acetate	51-54	ornithine decarboxylase, structural 1	Mus musculus	62-65
3191479-5	1988	Similarly, citral treatment decreased the ability of retinol, but not of retinoic acid, to inhibit the induction of epidermal ornithine decarboxylase activity by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	181-217	ornithine decarboxylase, structural 1	Mus musculus	126-149
3191479-6	1988	Although citral had little effect on epidermal ornithine decarboxylase activity when applied alone, it potentiated the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	168-204	ornithine decarboxylase, structural 1	Mus musculus	132-155
3191479-8	1988	Furthermore, the ability of citral to potentiate the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate suggests that modulation of the retinol oxidation pathway by such agents may enhance susceptibility to tumor promoters.	Tetradecanoylphorbol Acetate	102-138	ornithine decarboxylase, structural 1	Mus musculus	66-89
3071079-3	1988	These monoclonal antibodies (FO-120 &amp; FO-145) detected fos gene products induced in a human monocyte cell line (U-937) by phorbol acetate (TPA) and induced in both human and mouse fibroblast cell lines (284, BALB/c 3T3) by serum-stimulation.	Tetradecanoylphorbol Acetate	143-146	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	59-62
3142689-1	1988	Binding of the human transcription factor Jun/AP-1 to a conserved 8 bp nucleotide sequence (TRE) is responsible for increased transcription of different cellular genes in response to tumor promoters, such as TPA, and serum factors.	Tetradecanoylphorbol Acetate	208-211	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	46-50
3142689-2	1988	Enhanced Jun/AP-1 activity in TPA-stimulated cells is regulated by two different mechanisms: a posttranslational event acting on pre-existing Jun/AP-1 molecules, and transcriptional activation of jun gene expression leading to an increase in the total amount of Jun/AP-1.	Tetradecanoylphorbol Acetate	30-33	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-17
3142689-2	1988	Enhanced Jun/AP-1 activity in TPA-stimulated cells is regulated by two different mechanisms: a posttranslational event acting on pre-existing Jun/AP-1 molecules, and transcriptional activation of jun gene expression leading to an increase in the total amount of Jun/AP-1.	Tetradecanoylphorbol Acetate	30-33	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	146-150
3142689-2	1988	Enhanced Jun/AP-1 activity in TPA-stimulated cells is regulated by two different mechanisms: a posttranslational event acting on pre-existing Jun/AP-1 molecules, and transcriptional activation of jun gene expression leading to an increase in the total amount of Jun/AP-1.	Tetradecanoylphorbol Acetate	30-33	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	146-150
3142689-3	1988	Induction of jun transcription in response to TPA is mediated by binding of Jun/AP-1 to a high-affinity AP-1 binding site in the jun promoter region.	Tetradecanoylphorbol Acetate	46-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-84
3142689-3	1988	Induction of jun transcription in response to TPA is mediated by binding of Jun/AP-1 to a high-affinity AP-1 binding site in the jun promoter region.	Tetradecanoylphorbol Acetate	46-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-108
3142689-4	1988	Site-specific mutagenesis of this binding site prevents TPA induction and trans-activation by Jun/AP-1.	Tetradecanoylphorbol Acetate	56-59	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-102
2907482-0	1988	Induction of vimentin synthesis in a murine myeloma cell line by TPA is strongly dependent on the composition of the cell culture medium.	Tetradecanoylphorbol Acetate	65-68	vimentin	Mus musculus	13-21
2907482-1	1988	MPC-11 mouse plasmacytoma cells virtually lacking intermediate filament (IF) proteins can be induced to synthesize and accumulate the IF protein vimentin by treatment with the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	206-242	vimentin	Mus musculus	145-153
2907482-1	1988	MPC-11 mouse plasmacytoma cells virtually lacking intermediate filament (IF) proteins can be induced to synthesize and accumulate the IF protein vimentin by treatment with the tumor promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	244-247	vimentin	Mus musculus	145-153
2907482-3	1988	Vimentin synthesis could be elicited by a TPA concentration as low as 10(-9) M in cells grown in HB-102 serum-free medium.	Tetradecanoylphorbol Acetate	42-45	vimentin	Mus musculus	0-8
2907482-4	1988	Transfer of these cells to medium containing 15% fetal calf cerum (FCS) greatly reduced the ability of these cells to synthesize vimentin upon TPA treatment.	Tetradecanoylphorbol Acetate	143-146	vimentin	Bos taurus	129-137
2907482-5	1988	After 50 generations of culture in the presence of FCS, induction of vimentin synthesis was barely detectable even at a TPA concentration of 10(-6) M. Addition of FCS to cells grown in serum-free medium partially suppressed vimentin induction by TPA.	Tetradecanoylphorbol Acetate	120-123	vimentin	Mus musculus	69-77
2907482-5	1988	After 50 generations of culture in the presence of FCS, induction of vimentin synthesis was barely detectable even at a TPA concentration of 10(-6) M. Addition of FCS to cells grown in serum-free medium partially suppressed vimentin induction by TPA.	Tetradecanoylphorbol Acetate	246-249	vimentin	Mus musculus	69-77
2907482-5	1988	After 50 generations of culture in the presence of FCS, induction of vimentin synthesis was barely detectable even at a TPA concentration of 10(-6) M. Addition of FCS to cells grown in serum-free medium partially suppressed vimentin induction by TPA.	Tetradecanoylphorbol Acetate	246-249	vimentin	Mus musculus	224-232
2907482-6	1988	This suppression seems to be due, at least in part, to nondialyzable, heat-sensitive components of FCS, since the dialyzable fraction even enhanced vimentin induction by TPA.	Tetradecanoylphorbol Acetate	170-173	vimentin	Mus musculus	148-156
2907482-7	1988	When cells grown in the presence of FCS were transferred back to serum-free medium, their ability to synthesize vimentin in response to TPA treatment was readily restored.	Tetradecanoylphorbol Acetate	136-139	vimentin	Mus musculus	112-120
2907482-8	1988	The individual components of serum-free medium which proved to support vimentin induction by TPA were insulin and the unsaturated fatty acids oleic acid and linoleic acid.	Tetradecanoylphorbol Acetate	93-96	vimentin	Mus musculus	71-79
3265113-3	1988	Levels of hCS-1 gene mRNA and hCS release were increased by thyroid hormone, dexamethasone, a cyclic adenosine monophosphate (cAMP) analogue (8-bromo-cAMP), and phorbol ester, phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	176-207	chorionic somatomammotropin hormone 1	Homo sapiens	10-15
3265113-3	1988	Levels of hCS-1 gene mRNA and hCS release were increased by thyroid hormone, dexamethasone, a cyclic adenosine monophosphate (cAMP) analogue (8-bromo-cAMP), and phorbol ester, phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	209-212	chorionic somatomammotropin hormone 1	Homo sapiens	10-15
3179309-2	1988	In BALB/c 3T3 preadipose cells, TPA has previously been shown to rapidly inhibit Na+K+Cl- -cotransport activity, stimulate 2-deoxyglucose uptake and induce ornithine decarboxylase activity.	Tetradecanoylphorbol Acetate	32-35	ornithine decarboxylase, structural 1	Mus musculus	156-179
3068231-8	1988	Phorbol myristate acetate (PMA), a pharmacological activator of the lipid and CA++-dependent protein kinase C, was shown to induce nuclear proto-oncogene mRNA in the GM-CSF-dependent cell line.	Tetradecanoylphorbol Acetate	0-25	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	166-172
3068231-8	1988	Phorbol myristate acetate (PMA), a pharmacological activator of the lipid and CA++-dependent protein kinase C, was shown to induce nuclear proto-oncogene mRNA in the GM-CSF-dependent cell line.	Tetradecanoylphorbol Acetate	27-30	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	166-172
2970356-6	1988	Endogenous production of IL-2 after stimulation with PHA and phorbol myristate acetate was positive in 3/9 CD3- and in 8/8 CD3+, CD4-, CD8- clones.	Tetradecanoylphorbol Acetate	61-86	CD8a molecule	Homo sapiens	135-138
3192268-1	1988	Pretreatment of EL4 cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA) for 30 min renders them resistant to lysis by activated macrophages (M phi).	Tetradecanoylphorbol Acetate	31-68	epilepsy 4	Mus musculus	16-19
3192268-1	1988	Pretreatment of EL4 cells with 12-O-tetradecanoyl phorbol-13-acetate (TPA) for 30 min renders them resistant to lysis by activated macrophages (M phi).	Tetradecanoylphorbol Acetate	70-73	epilepsy 4	Mus musculus	16-19
3192268-2	1988	This resistance was augmented two to three-fold when TPA-treated EL4 cells were incubated for 2-6 hr prior to co-culture with M phi.	Tetradecanoylphorbol Acetate	53-56	epilepsy 4	Mus musculus	65-68
3042043-4	1988	GM-CSF significantly increased phorbol myristate acetate- and zymosan-elicited H2O2 release by resident and thioglycollate-elicited macrophages after 48 hours in vitro.	Tetradecanoylphorbol Acetate	31-56	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-6
2967092-12	1988	TPA and OAG induced a biphasic Ca2+ transient that could be detected only with aequorin.	Tetradecanoylphorbol Acetate	0-3	carbonic anhydrase 2	Homo sapiens	31-34
2967092-15	1988	Prestimulation of cells with TPA or OAG prevented the aequorin transient caused by cholecystokinin and vice versa, suggesting that TPA, OAG and cholecystokinin activate the same pathways of Ca2+ entry into the cytosol from the intracellular store(s) or the extracellular space.	Tetradecanoylphorbol Acetate	29-32	carbonic anhydrase 2	Homo sapiens	190-193
2967092-15	1988	Prestimulation of cells with TPA or OAG prevented the aequorin transient caused by cholecystokinin and vice versa, suggesting that TPA, OAG and cholecystokinin activate the same pathways of Ca2+ entry into the cytosol from the intracellular store(s) or the extracellular space.	Tetradecanoylphorbol Acetate	131-134	carbonic anhydrase 2	Homo sapiens	190-193
34374443-7	2021	APLME suppressed the activities of MMP-2 and MMP-9 in PMA (phorbol myristate acetate)-treated HT1080 cells.	Tetradecanoylphorbol Acetate	59-84	matrix metallopeptidase 9	Homo sapiens	45-50
34171483-9	2021	Integrin alpha6 and beta4 expression was also reduced when alpha2 expression was chemically induced using tetradecanoyl-phorbol-acetate (TPA).	Tetradecanoylphorbol Acetate	106-135	integrin subunit alpha 6	Homo sapiens	0-15
34171483-9	2021	Integrin alpha6 and beta4 expression was also reduced when alpha2 expression was chemically induced using tetradecanoyl-phorbol-acetate (TPA).	Tetradecanoylphorbol Acetate	137-140	integrin subunit alpha 6	Homo sapiens	0-15
34451927-9	2021	These results suggest that generation of TRPA1 endogenous agonists in the PMS-EAE mouse model may sensitise TRPA1 in trigeminal nociceptors to elicit PMA.	Tetradecanoylphorbol Acetate	150-153	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	41-46
34451927-9	2021	These results suggest that generation of TRPA1 endogenous agonists in the PMS-EAE mouse model may sensitise TRPA1 in trigeminal nociceptors to elicit PMA.	Tetradecanoylphorbol Acetate	150-153	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	108-113
34439276-6	2021	We found that phorbol myristate acetate-induced THP-1 macrophages took up EVs-miR-21-5p from EC109 or EC9706 cells and were transformed into M2 macrophages.	Tetradecanoylphorbol Acetate	14-39	microRNA 215	Homo sapiens	78-87
34422811-7	2021	Results: Overexpression of lncRNA TPA decreased the expression of E-cadherin, and significantly increased the expression of Vimentin, fibronectin and TGF-beta1 (p < 0.01), and increased the migration rate, migration ability and invasion ability of cell group (P < 0.01).	Tetradecanoylphorbol Acetate	34-37	vimentin	Mus musculus	124-132
34382410-7	2021	Silencing PCM1 significantly increased the level of IFN-gamma in Lv-1645 cells stimulated by PMA.	Tetradecanoylphorbol Acetate	93-96	pericentriolar material 1	Homo sapiens	10-14
34382410-8	2021	Conclusion: This study revealed that lncRNA-ENST00000421645 mediates the production of IFN-gamma by sponging PCM1 protein after PMA stimulation.	Tetradecanoylphorbol Acetate	128-131	pericentriolar material 1	Homo sapiens	109-113
34512147-7	2021	We further demonstrate that c-Jun, AR, and DNA methyltransferase-1 (DNMT1) form a complex in the 12-O-tetradecanoyl phorbol-13-acetate (TPA) response elements (TREs) region of the NDRG1 promoter, which suppresses NDRG1 transcription through DNA hypermethylation.	Tetradecanoylphorbol Acetate	97-134	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-33
34512147-7	2021	We further demonstrate that c-Jun, AR, and DNA methyltransferase-1 (DNMT1) form a complex in the 12-O-tetradecanoyl phorbol-13-acetate (TPA) response elements (TREs) region of the NDRG1 promoter, which suppresses NDRG1 transcription through DNA hypermethylation.	Tetradecanoylphorbol Acetate	97-134	DNA methyltransferase 1	Homo sapiens	43-66
34512147-7	2021	We further demonstrate that c-Jun, AR, and DNA methyltransferase-1 (DNMT1) form a complex in the 12-O-tetradecanoyl phorbol-13-acetate (TPA) response elements (TREs) region of the NDRG1 promoter, which suppresses NDRG1 transcription through DNA hypermethylation.	Tetradecanoylphorbol Acetate	97-134	DNA methyltransferase 1	Homo sapiens	68-73
34512147-7	2021	We further demonstrate that c-Jun, AR, and DNA methyltransferase-1 (DNMT1) form a complex in the 12-O-tetradecanoyl phorbol-13-acetate (TPA) response elements (TREs) region of the NDRG1 promoter, which suppresses NDRG1 transcription through DNA hypermethylation.	Tetradecanoylphorbol Acetate	97-134	N-myc downstream regulated 1	Homo sapiens	180-185
34376910-4	2021	Gene and protein expression analyses revealed that luteolin significantly suppressed cellular tryptophan hydroxylase 1 expression induced by phorbol 12-myristate 13-acetate stimulation.	Tetradecanoylphorbol Acetate	141-172	tryptophan hydroxylase 1	Rattus norvegicus	94-118
34093777-6	2021	The results demonstrated that triptolide decreased the expression of MMP-9 through inhibition of the TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK) and the downregulation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) activity.	Tetradecanoylphorbol Acetate	101-104	matrix metallopeptidase 9	Homo sapiens	69-74
34248948-6	2021	Furthermore, a Syk inhibitor attenuated NETs, that activated by phorbol myristate acetate (PMA; a NETs activator) or lipopolysaccharide (LPS; a potent inflammatory stimulator), more prominently in Fcgr2b-/- neutrophils than the WT cells as determined by dsDNA, PAD4 and MPO.	Tetradecanoylphorbol Acetate	64-89	spleen tyrosine kinase	Mus musculus	15-18
34248948-6	2021	Furthermore, a Syk inhibitor attenuated NETs, that activated by phorbol myristate acetate (PMA; a NETs activator) or lipopolysaccharide (LPS; a potent inflammatory stimulator), more prominently in Fcgr2b-/- neutrophils than the WT cells as determined by dsDNA, PAD4 and MPO.	Tetradecanoylphorbol Acetate	64-89	myeloperoxidase	Mus musculus	270-273
34248948-6	2021	Furthermore, a Syk inhibitor attenuated NETs, that activated by phorbol myristate acetate (PMA; a NETs activator) or lipopolysaccharide (LPS; a potent inflammatory stimulator), more prominently in Fcgr2b-/- neutrophils than the WT cells as determined by dsDNA, PAD4 and MPO.	Tetradecanoylphorbol Acetate	91-94	spleen tyrosine kinase	Mus musculus	15-18
34068760-10	2021	However, they only decreased PMA-induced p47phox phosphorylation.	Tetradecanoylphorbol Acetate	29-32	neutrophil cytosolic factor 1	Homo sapiens	41-48
34760627-9	2021	In our recent report, we found that PKCdelta-mediated ROS generation may interfere with the association of RKIP with heat shock protein 60 (HSP60)/MAPK complex via oxidation of HSP60 triggered by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	215-252	phosphatidylethanolamine binding protein 1	Homo sapiens	107-111
34760627-9	2021	In our recent report, we found that PKCdelta-mediated ROS generation may interfere with the association of RKIP with heat shock protein 60 (HSP60)/MAPK complex via oxidation of HSP60 triggered by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	215-252	heat shock protein family D (Hsp60) member 1	Homo sapiens	117-138
34760627-9	2021	In our recent report, we found that PKCdelta-mediated ROS generation may interfere with the association of RKIP with heat shock protein 60 (HSP60)/MAPK complex via oxidation of HSP60 triggered by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	215-252	heat shock protein family D (Hsp60) member 1	Homo sapiens	140-145
34760627-9	2021	In our recent report, we found that PKCdelta-mediated ROS generation may interfere with the association of RKIP with heat shock protein 60 (HSP60)/MAPK complex via oxidation of HSP60 triggered by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	215-252	heat shock protein family D (Hsp60) member 1	Homo sapiens	177-182
34846450-6	2021	Here, we designed two new aggregation-induced emission (AIE) molecules with activated alkyl groups (TPE-PPO and TPA-TPO).	Tetradecanoylphorbol Acetate	112-115	thyroid peroxidase	Homo sapiens	116-119
35513847-9	2022	PBMCs produced high levels of IFN-gamma, IL-4, and IL-17A after stimulation with PMA/Ionomycin and Con A.	Tetradecanoylphorbol Acetate	81-84	interleukin-4	Ovis aries	41-45
35418879-6	2022	In isolated hearts of normal rats, the PKC agonist, phorbol-12-myristate-13-acetate (PMA), induced prolongation of the QRS complex.	Tetradecanoylphorbol Acetate	52-83	protein kinase C, gamma	Rattus norvegicus	39-42
35418879-6	2022	In isolated hearts of normal rats, the PKC agonist, phorbol-12-myristate-13-acetate (PMA), induced prolongation of the QRS complex.	Tetradecanoylphorbol Acetate	85-88	protein kinase C, gamma	Rattus norvegicus	39-42
35230372-9	2022	MUG1 blunted while Lgals3 amplified neutrophil degranulation in response to phorbol 12-myristate 13-acetate or interleukin-1beta, as measured by MMP-9 secretion.	Tetradecanoylphorbol Acetate	76-107	matrix metallopeptidase 9	Homo sapiens	145-150
2836109-5	1988	In addition, captopril, MPG, or NAC, but not teprotide or enalaprilat, scavenge superoxide anion production by the purine-xanthine oxidase reaction and by canine neutrophils activated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	189-214	N-methylpurine DNA glycosylase	Canis lupus familiaris	24-27
9870925-10	1999	Although the surface expression of TNF-R assessed by 125I-TNF specific binding was decreased in the presence of hydrogen peroxide or PMA, TNF-RI mRNA transcript levels remained unchanged.	Tetradecanoylphorbol Acetate	133-136	TNF receptor superfamily member 1A	Homo sapiens	35-40
10370867-9	1999	As judged by the reverse transcriptase-polymerase chain reaction, resveratrol selectively inhibited TPA-induced expression of c-fos and transforming growth factor-beta 1 (TGF-beta 1), but did not affect other TPA-induced gene products including COX-1, COX-2, c-myc, c-jun, and tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	100-103	FBJ osteosarcoma oncogene	Mus musculus	126-131
3405206-8	1988	The level of gamma-actin mRNA was elevated in resting cells by 12-O-tetradecanoylphorbol-13-acetate, calcium ionophore A23187, and bombesin and to a lesser extent by cholera toxin, fibroblast-derived growth factor, and dibutyryl cyclic AMP.	Tetradecanoylphorbol Acetate	63-99	actin, gamma, cytoplasmic 1	Mus musculus	13-24
9891974-4	1998	Addition of the phorbol ester PMA (phorbol 12-myristate 13-acetate) reversed the inhibition of endosome fusion caused by a Rab5 negative mutant.	Tetradecanoylphorbol Acetate	30-33	RAB5A, member RAS oncogene family	Homo sapiens	123-127
3365842-1	1988	Hyperplasiogenic and tumor-promoting phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate or 12-O-retinoylphorbol-13-acetate induce the sequential transient expression of the proto-oncogenes c-fos and c-myc and the ornithine decarboxylase gene in mouse skin in vivo.	Tetradecanoylphorbol Acetate	60-96	ornithine decarboxylase, structural 1	Mus musculus	222-245
9891974-4	1998	Addition of the phorbol ester PMA (phorbol 12-myristate 13-acetate) reversed the inhibition of endosome fusion caused by a Rab5 negative mutant.	Tetradecanoylphorbol Acetate	35-66	RAB5A, member RAS oncogene family	Homo sapiens	123-127
9874514-5	1998	Addition of TPA from confluence in both media stimulated LPL activity on day 14 as well as ME activity on day 17.	Tetradecanoylphorbol Acetate	12-15	lipoprotein lipase	Homo sapiens	57-60
3259927-0	1988	Effect of tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate on CD 7 expression by T lineage cells.	Tetradecanoylphorbol Acetate	25-62	CD7 molecule	Homo sapiens	66-70
3259927-3	1988	CD 7 was found to be rapidly down-regulated by 12-O-tetradecanoylphorbol 13-acetate (TPA) from mature T cell surface.	Tetradecanoylphorbol Acetate	47-83	CD7 molecule	Homo sapiens	0-4
10052620-12	1998	Thus, in our non-palindromic oligonucleotide the water molecules bind differently to A11 and A15 although both adenines are part of a TpA step.	Tetradecanoylphorbol Acetate	134-137	DXS435E	Homo sapiens	85-88
3259927-3	1988	CD 7 was found to be rapidly down-regulated by 12-O-tetradecanoylphorbol 13-acetate (TPA) from mature T cell surface.	Tetradecanoylphorbol Acetate	85-88	CD7 molecule	Homo sapiens	0-4
3259927-5	1988	Within 2 h, TPA at 10 to 30 ng/ml induced a complete down-regulation of CD 7.	Tetradecanoylphorbol Acetate	12-15	CD7 molecule	Homo sapiens	72-76
3259927-6	1988	Twenty-four hours later, the reappearance of CD 7 on TPA-treated cells was observed.	Tetradecanoylphorbol Acetate	53-56	CD7 molecule	Homo sapiens	45-49
3259927-8	1988	In contrast, CD 7 expression on thymocytes was resistant to the effect of TPA.	Tetradecanoylphorbol Acetate	74-77	CD7 molecule	Homo sapiens	13-17
3259927-9	1988	In addition, certain leukemic T cells were also resistant to TPA-induced CD 7 down-regulation.	Tetradecanoylphorbol Acetate	61-64	CD7 molecule	Homo sapiens	73-77
9844925-5	1998	Here, we show that the PMA-induced phenotypic changes of K562 cells such as polylobulation of the nucleus and Pyk2 expression are independent of MAPK activation.	Tetradecanoylphorbol Acetate	23-26	protein tyrosine kinase 2 beta	Homo sapiens	110-114
3259927-10	1988	The mechanism underlying TPA-induced CD 7 down-regulation was investigated further.	Tetradecanoylphorbol Acetate	25-28	CD7 molecule	Homo sapiens	37-41
3259927-13	1988	Thus, it is concluded that the processes of protein kinase C activation and/or cytosolic calcium influx are not sufficient for TPA-induced CD 7 down-regulation; other pathways induced by TPA may be responsible.	Tetradecanoylphorbol Acetate	127-130	CD7 molecule	Homo sapiens	139-143
2835653-1	1988	The aim of the present study was to investigate the effects of staurosporine on phorbol-myristate acetate (PMA)-induced activation of protein kinase C (PKC) and the desensitization of leukotriene D4 (LTD4)-stimulated Ca2+ mobilization in rat basophilic leukemia (RBL-1) cells.	Tetradecanoylphorbol Acetate	80-105	RB transcriptional corepressor like 1	Rattus norvegicus	263-268
9972133-4	1998	Doxycycline (50 microM) completely inhibited the phorbol-12-myristate-13-acetate (PMA)-mediated induction of MMP-8 and MMP-9, as measured by Western blotting and gelatin zymography, respectively.	Tetradecanoylphorbol Acetate	49-80	matrix metallopeptidase 8	Homo sapiens	109-114
2835653-1	1988	The aim of the present study was to investigate the effects of staurosporine on phorbol-myristate acetate (PMA)-induced activation of protein kinase C (PKC) and the desensitization of leukotriene D4 (LTD4)-stimulated Ca2+ mobilization in rat basophilic leukemia (RBL-1) cells.	Tetradecanoylphorbol Acetate	107-110	RB transcriptional corepressor like 1	Rattus norvegicus	263-268
2835653-6	1988	Treatment of RBL-1 cells with PMA resulted in translocation and activation of PKC from the cytosol to the membrane fraction.	Tetradecanoylphorbol Acetate	30-33	RB transcriptional corepressor like 1	Rattus norvegicus	13-18
3365770-11	1988	To determine if the mechanism by which PMA or fresh serum altered intracellular glutathione and ODC activity was through the generation of oxygen radicals, EL4 cells were cultured with free radical scavengers.	Tetradecanoylphorbol Acetate	39-42	ornithine decarboxylase, structural 1	Mus musculus	96-99
9972133-4	1998	Doxycycline (50 microM) completely inhibited the phorbol-12-myristate-13-acetate (PMA)-mediated induction of MMP-8 and MMP-9, as measured by Western blotting and gelatin zymography, respectively.	Tetradecanoylphorbol Acetate	82-85	matrix metallopeptidase 8	Homo sapiens	109-114
9863665-12	1998	However, IL-1 (10 ng ml(-1)), foetal bovine serum (10%) and phorbol-12-myristate-13-acetate (3 microg ml(-1)) were effective positive control secretagogues of all the cytokines, PGE2 and MMP-1, respectively, from these cells.	Tetradecanoylphorbol Acetate	60-91	matrix metallopeptidase 1	Homo sapiens	187-192
2830906-1	1988	Activation of protein kinase C in erythrocytes by 4-beta-phorbol 12-myristate 13-acetate (PMA) resulted in a parallel stimulation (time course and dose response) of the phosphorylation of both membrane proteins (heterodimers of 107 kDa and 97 kDa, protein 4.1 and 4.9, respectively) and of phosphatidylinositol 4-phosphate (PIP) and, to a lesser extent, of phosphatidylinositol 4,5-bisphosphate (PIP2).	Tetradecanoylphorbol Acetate	50-88	erythrocyte membrane protein band 4.1	Homo sapiens	248-267
2830906-1	1988	Activation of protein kinase C in erythrocytes by 4-beta-phorbol 12-myristate 13-acetate (PMA) resulted in a parallel stimulation (time course and dose response) of the phosphorylation of both membrane proteins (heterodimers of 107 kDa and 97 kDa, protein 4.1 and 4.9, respectively) and of phosphatidylinositol 4-phosphate (PIP) and, to a lesser extent, of phosphatidylinositol 4,5-bisphosphate (PIP2).	Tetradecanoylphorbol Acetate	90-93	erythrocyte membrane protein band 4.1	Homo sapiens	248-267
9783809-5	1998	RA enhanced IL-1beta and inhibited IL-1ra production by 4beta phorbol 12beta-myristate-13alpha acetate (PMA)- and lipopolysaccharide (LPS)-stimulated human alveolar macrophages.	Tetradecanoylphorbol Acetate	104-107	interleukin 1 receptor antagonist	Homo sapiens	35-41
9765254-8	1998	Furthermore, translocation of p47(phox) to the membrane in response to phorbol myristate acetate or fMet-Leu-Phe was reduced in beta-PKC-depleted cells.	Tetradecanoylphorbol Acetate	71-96	pleckstrin	Homo sapiens	30-33
3257409-3	1988	The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, increased c-fos mRNA levels 4- to 5-fold above control.	Tetradecanoylphorbol Acetate	19-55	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	67-72
9765254-8	1998	Furthermore, translocation of p47(phox) to the membrane in response to phorbol myristate acetate or fMet-Leu-Phe was reduced in beta-PKC-depleted cells.	Tetradecanoylphorbol Acetate	71-96	pleckstrin	Homo sapiens	34-38
3345563-2	1988	These cell lines contain a 20- to 53-fold increase in PKC activity and exhibit dramatically enhanced morphologic changes following exposure to the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	201-204	protein kinase C, gamma	Rattus norvegicus	54-57
3345563-4	1988	In contrast to control cells, which display complete anchorage dependence, PKC-overproducing cells form small colonies in soft agar in the absence of TPA and large colonies in the presence of TPA.	Tetradecanoylphorbol Acetate	150-153	protein kinase C, gamma	Rattus norvegicus	75-78
9758695-8	1998	The data presented here suggest that the inhibition of DPIV enzymatic activity induces a inhibitory signal transmitted by tyrosine kinases which leads to a block in a PMA-induced downstream pathway.	Tetradecanoylphorbol Acetate	167-170	dipeptidyl peptidase 4	Homo sapiens	55-59
3345563-4	1988	In contrast to control cells, which display complete anchorage dependence, PKC-overproducing cells form small colonies in soft agar in the absence of TPA and large colonies in the presence of TPA.	Tetradecanoylphorbol Acetate	192-195	protein kinase C, gamma	Rattus norvegicus	75-78
9801169-3	1998	Here, through the use of several compounds inhibiting induction of Fas-L, we show that, in a Th1 clone, a protein kinase C (PKC) independent pathway activated by TCR stimulation is distinguishible from a PKC dependent pathway activated by either phorbol 12-myristate 13-acetate (PMA)/ionomycin or asynchronous stimulation of TCR and CD4 as occurs in gp120-apoptosis.	Tetradecanoylphorbol Acetate	246-277	Fas ligand	Homo sapiens	67-72
3281655-1	1988	The potentiation of glucose-stimulated insulin release induced by 100 nM-12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by clomiphene, an inhibitor of protein kinase C (PK C), in a dose-dependent manner.	Tetradecanoylphorbol Acetate	73-109	protein kinase C, gamma	Rattus norvegicus	161-177
3281655-1	1988	The potentiation of glucose-stimulated insulin release induced by 100 nM-12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by clomiphene, an inhibitor of protein kinase C (PK C), in a dose-dependent manner.	Tetradecanoylphorbol Acetate	73-109	protein kinase C, gamma	Rattus norvegicus	179-183
3281655-1	1988	The potentiation of glucose-stimulated insulin release induced by 100 nM-12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by clomiphene, an inhibitor of protein kinase C (PK C), in a dose-dependent manner.	Tetradecanoylphorbol Acetate	111-114	protein kinase C, gamma	Rattus norvegicus	161-177
3281655-1	1988	The potentiation of glucose-stimulated insulin release induced by 100 nM-12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by clomiphene, an inhibitor of protein kinase C (PK C), in a dose-dependent manner.	Tetradecanoylphorbol Acetate	111-114	protein kinase C, gamma	Rattus norvegicus	179-183
3281655-3	1988	Islet PK C activity, associated with a particulate fraction, was stimulated maximally by 100 nM-TPA.	Tetradecanoylphorbol Acetate	96-99	protein kinase C, gamma	Rattus norvegicus	6-10
9801169-3	1998	Here, through the use of several compounds inhibiting induction of Fas-L, we show that, in a Th1 clone, a protein kinase C (PKC) independent pathway activated by TCR stimulation is distinguishible from a PKC dependent pathway activated by either phorbol 12-myristate 13-acetate (PMA)/ionomycin or asynchronous stimulation of TCR and CD4 as occurs in gp120-apoptosis.	Tetradecanoylphorbol Acetate	279-282	Fas ligand	Homo sapiens	67-72
9808167-5	1998	The signal transmitting function of CD73 is also conserved, as splenic T cells treated with anti-CD73 mAb plus phorbol 12-myristate 13-acetate proliferate and secrete IL-2.	Tetradecanoylphorbol Acetate	111-142	5' nucleotidase, ecto	Mus musculus	36-40
2892695-3	1988	Herein we show that pretreatment of these cells with phorbol 12-myristate 13-acetate (PMA), a known activator of protein kinase C, attenuates the ANF-stimulated cyclic GMP accumulation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	53-84	natriuretic peptide A	Rattus norvegicus	146-149
2892695-3	1988	Herein we show that pretreatment of these cells with phorbol 12-myristate 13-acetate (PMA), a known activator of protein kinase C, attenuates the ANF-stimulated cyclic GMP accumulation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	86-89	natriuretic peptide A	Rattus norvegicus	146-149
2892695-4	1988	The half maximum inhibitory concentration of PMA was 10(-10) M. When these cells were incubated with PMA in the presence of 1-(5-isoquinolinyl-sulfonyl)-2-methyl piperazine, a protein kinase C inhibitor, the PMA-mediated attenuation of ANF-stimulated cyclic GMP formation is blocked.	Tetradecanoylphorbol Acetate	45-48	natriuretic peptide A	Rattus norvegicus	236-239
9808167-5	1998	The signal transmitting function of CD73 is also conserved, as splenic T cells treated with anti-CD73 mAb plus phorbol 12-myristate 13-acetate proliferate and secrete IL-2.	Tetradecanoylphorbol Acetate	111-142	interleukin 2	Mus musculus	167-171
2892695-4	1988	The half maximum inhibitory concentration of PMA was 10(-10) M. When these cells were incubated with PMA in the presence of 1-(5-isoquinolinyl-sulfonyl)-2-methyl piperazine, a protein kinase C inhibitor, the PMA-mediated attenuation of ANF-stimulated cyclic GMP formation is blocked.	Tetradecanoylphorbol Acetate	101-104	natriuretic peptide A	Rattus norvegicus	236-239
2892695-4	1988	The half maximum inhibitory concentration of PMA was 10(-10) M. When these cells were incubated with PMA in the presence of 1-(5-isoquinolinyl-sulfonyl)-2-methyl piperazine, a protein kinase C inhibitor, the PMA-mediated attenuation of ANF-stimulated cyclic GMP formation is blocked.	Tetradecanoylphorbol Acetate	101-104	natriuretic peptide A	Rattus norvegicus	236-239
9796919-4	1998	When another T cell hybridoma, KMIs-8.3.5, was treated with A23187 and phorbol myristate acetate, which leads to activation-induced apoptosis, Tcf-1 expression was again greatly reduced.	Tetradecanoylphorbol Acetate	71-96	transcription factor 7	Homo sapiens	143-148
9768673-7	1998	Leptin production and gene expression in BeWo cells were increased by treatment with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	85-110	leptin	Homo sapiens	0-6
3076326-0	1988	Mechanisms involved in ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate, a potent mouse skin tumor promoter and an activator of protein kinase C. ODC, the first enzyme in mammalian polyamine biosynthesis, is rapidly induced in response to a wide variety of growth stimuli.	Tetradecanoylphorbol Acetate	60-96	ornithine decarboxylase, structural 1	Mus musculus	23-46
3076326-3	1988	Our results indicate that TPA-induced ODC activity is regulated at the transcriptional level.	Tetradecanoylphorbol Acetate	26-29	ornithine decarboxylase, structural 1	Mus musculus	38-41
3076326-4	1988	An initial signal in ODC induction by TPA is not clear.	Tetradecanoylphorbol Acetate	38-41	ornithine decarboxylase, structural 1	Mus musculus	21-24
3076326-5	1988	We have suggested that TPA-increased accumulation of epidermal prostaglandins is required, but not sufficient, for ODC induction by TPA.	Tetradecanoylphorbol Acetate	23-26	ornithine decarboxylase, structural 1	Mus musculus	115-118
3076326-8	1988	The involvement of cyclic nucleotides in ODC induction by TPA is controversial.	Tetradecanoylphorbol Acetate	58-61	ornithine decarboxylase, structural 1	Mus musculus	41-44
3076326-9	1988	Also, generation of free radicals appears to be involved in ODC induction by TPA.	Tetradecanoylphorbol Acetate	77-80	ornithine decarboxylase, structural 1	Mus musculus	60-63
35424795-3	2022	The TPA cross section of trithiophene-based compound INT3 was found to be larger than that of triphenylamine-based compound INB3 in the red region (650-800 nm), which is attributed to its longer pi-conjugated structure and better molecular planarity.	Tetradecanoylphorbol Acetate	4-7	notch receptor 4	Homo sapiens	53-57
35424795-4	2022	Interestingly, the effective NLA of INB3 was found to be larger than INT3 in the NIR region (800-1100 nm), which is related to the excited state absorption (ESA) induced by TPA.	Tetradecanoylphorbol Acetate	173-176	notch receptor 4	Homo sapiens	69-73
9768673-7	1998	Leptin production and gene expression in BeWo cells were increased by treatment with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	112-115	leptin	Homo sapiens	0-6
9733756-5	1998	Further studies to determine potential upstream elements of S6K activation revealed: (i) similar time course of activation for protein kinase C isoforms (alpha, gamma, and epsilon) and c-Raf, (ii) absence of accompanying phosphatidylinositol 3-kinase activation, (iii) activation of c-Src subsequent to p70(S6K), and (iv) similar changes in adult cardiocytes after treatment with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	380-416	ribosomal protein S6 kinase B1	Homo sapiens	60-63
35072213-5	2022	Phytohaemagglutinin-induced release of pro-inflammatory mediators from PBMCs and production of intracellular cytokines by CD4+ and CD8+ T cells stimulated with phorbol 12-myristate 13-acetate and ionomycin in the presence or absence of 10 mug/mL azithromycin and 10 nM budesonide were determined using enzyme linked immunosorbent assay and flow cytometry.	Tetradecanoylphorbol Acetate	160-191	CD8a molecule	Homo sapiens	131-134
3076326-10	1988	Data summarized in this chapter indicate that activation of PKC may be an initial step in ODC induction by TPA.	Tetradecanoylphorbol Acetate	107-110	ornithine decarboxylase, structural 1	Mus musculus	90-93
9737343-12	1998	These results suggest that PA formed as a consequence of the activation of PLD by TPA is rapidly converted to arachidonic acid via a PAP/DAG lipase pathway, followed by a gradual conversion of arachidonic acid to PGE2 by COX in both UMR-106 cells and isolated adult osteoblastic cells, and that neither phospholipase A2 nor phospholipase C is involved in the TPA-induced PGE2 production.	Tetradecanoylphorbol Acetate	82-85	phospholipase A2 group IB	Rattus norvegicus	303-319
35127555-9	2021	Higher level of CD69, ICOS and PD-1, lower level of CD62L, and decreased IFN-gamma producing after stimulation by PMA and ionomycin were found in gammadeltaT cells from infected mice, compared with naive mice.	Tetradecanoylphorbol Acetate	114-117	inducible T cell co-stimulator	Mus musculus	22-26
9744505-6	1998	Immunofluorescence showed that PMA induced a rapid nuclear translocation of p42 MAP kinase of similar magnitude in the presence or absence of mutant ras expression.	Tetradecanoylphorbol Acetate	31-34	cyclin dependent kinase 20	Homo sapiens	76-79
2964282-0	1988	Calmodulin involvement in TPA and DDT induced inhibition of intercellular communication.	Tetradecanoylphorbol Acetate	26-29	LOC100759184	Cricetulus griseus	0-10
2827650-3	1987	Exposure of the cells to TPA resulted in a loss of cytosolic PK-C activity which was not accompanied by a concomitant increase of particulate activity.	Tetradecanoylphorbol Acetate	25-28	Prkca	Cavia porcellus	61-65
2514685-2	1989	Activators of protein kinase C, such as TPA, mellitin and phospholipase C and the calcium ionophore, A23187, induced c-fos mRNA in the presence or absence of cyclosporin A.	Tetradecanoylphorbol Acetate	40-43	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-122
9701566-6	1998	The amount of Munc-18-2 in the complex increases upon treatment of the cells with the protein kinase C activator phorbol myristate acetate, indicating a functional connection between the complex and cell signalling.	Tetradecanoylphorbol Acetate	113-138	syntaxin binding protein 2	Homo sapiens	14-23
9744958-12	1998	The data suggest that PMA enhances neuronal excitability via a protein kinase C-mediated increase in INaP at functionally critical subthreshold voltages.	Tetradecanoylphorbol Acetate	22-25	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta	Mus musculus	101-105
2607145-4	1989	When bovine lymph node cells (bLNC) were stimulated with the combination of concanavalin A (ConA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) for 24 h, 46.4 +/- 0.6% stained positive for IL-2 and, on average, each cell produced 0.92 +/- 0.6 pg of IL-2 in 24 h. Phytohemagglutinin (PHA) and TPA-stimulated human peripheral blood mononuclear cells (hPBMC) produced approximately the same amount.	Tetradecanoylphorbol Acetate	102-138	interleukin 2	Bos taurus	190-194
2607145-4	1989	When bovine lymph node cells (bLNC) were stimulated with the combination of concanavalin A (ConA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) for 24 h, 46.4 +/- 0.6% stained positive for IL-2 and, on average, each cell produced 0.92 +/- 0.6 pg of IL-2 in 24 h. Phytohemagglutinin (PHA) and TPA-stimulated human peripheral blood mononuclear cells (hPBMC) produced approximately the same amount.	Tetradecanoylphorbol Acetate	102-138	interleukin 2	Bos taurus	250-254
2824083-1	1987	Mouse skin papillomas and squamous cell carcinomas induced by initiation with 7,12-dimethylbenz[a]anthracene and promotion with phorbol esters, such as 12-O-tetradecanoyl phorbol-13-acetate, frequently contain an activated Harvey ras gene.	Tetradecanoylphorbol Acetate	152-189	Harvey rat sarcoma virus oncogene	Mus musculus	223-233
9716464-2	1998	A high percentage of beta-galactosidase-positive cells were detected in U937 and HL60 cultures at the late stage of macrophage-like differentiation induced by TPA.	Tetradecanoylphorbol Acetate	159-162	galactosidase, beta 1	Mus musculus	21-39
3677084-1	1987	Topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse skin results within 48 h in a 3-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating the reactive oxygen species superoxide and hydrogen peroxide.	Tetradecanoylphorbol Acetate	42-78	xanthine dehydrogenase	Mus musculus	151-167
3677084-1	1987	Topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse skin results within 48 h in a 3-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating the reactive oxygen species superoxide and hydrogen peroxide.	Tetradecanoylphorbol Acetate	42-78	xanthine dehydrogenase	Mus musculus	169-171
3677084-1	1987	Topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse skin results within 48 h in a 3-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating the reactive oxygen species superoxide and hydrogen peroxide.	Tetradecanoylphorbol Acetate	80-83	xanthine dehydrogenase	Mus musculus	151-167
3677084-1	1987	Topical application of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to SENCAR mouse skin results within 48 h in a 3-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating the reactive oxygen species superoxide and hydrogen peroxide.	Tetradecanoylphorbol Acetate	80-83	xanthine dehydrogenase	Mus musculus	169-171
2556385-2	1989	Transfection of the c-raf-1 cDNA or addition of TPA to NIH/3T3 cells stimulated the serum response element and TPA response element but not the cAMP response element.	Tetradecanoylphorbol Acetate	111-114	v-raf-leukemia viral oncogene 1	Mus musculus	20-27
2556385-4	1989	These results indicate that the activated c-raf-1 protein stimulates the serum response element and TPA response element in a manner independent of protein kinase C and cAMP-dependent protein kinase.	Tetradecanoylphorbol Acetate	100-103	v-raf-leukemia viral oncogene 1	Mus musculus	42-49
2819717-2	1989	The epidermis from SSIN mice treated with a single application of 12-O-tetradecanoylphorbol-13-acetate (TPA) displayed a large induction of ODC and a subsequent extensive hyperplasia.	Tetradecanoylphorbol Acetate	66-102	ornithine decarboxylase, structural 1	Mus musculus	140-143
2819717-2	1989	The epidermis from SSIN mice treated with a single application of 12-O-tetradecanoylphorbol-13-acetate (TPA) displayed a large induction of ODC and a subsequent extensive hyperplasia.	Tetradecanoylphorbol Acetate	104-107	ornithine decarboxylase, structural 1	Mus musculus	140-143
2819717-5	1989	The epidermis of C57BL/6J responds to a single application of TPA with a level of ODC induction similar to that of the SSIN mice.	Tetradecanoylphorbol Acetate	62-65	ornithine decarboxylase, structural 1	Mus musculus	82-85
9780004-6	1998	PKC mediated oncogene activation of the IGF-II gene presumably through action on Sp1 since (i) PKC activation by phorbol 12-myristate 13-acetate increased Sp1 expression, P3 and P4 activity and IGF-II mRNA in control but not in oncogene-transfected cells; and (ii) PKC inhibition by the PKC inhibitor Go6976 reduced Sp1, P3 and P4 activity and IGF-II mRNA in all three cell lines.	Tetradecanoylphorbol Acetate	113-144	insulin like growth factor 2	Homo sapiens	40-46
2819717-10	1989	It is concluded that, while hyperplasia remains an apparent requirement for tumor promotion, the ODC induction following an initial TPA treatment is insufficient for or not causally related to this hyperplasia.	Tetradecanoylphorbol Acetate	132-135	ornithine decarboxylase, structural 1	Mus musculus	97-100
9780004-6	1998	PKC mediated oncogene activation of the IGF-II gene presumably through action on Sp1 since (i) PKC activation by phorbol 12-myristate 13-acetate increased Sp1 expression, P3 and P4 activity and IGF-II mRNA in control but not in oncogene-transfected cells; and (ii) PKC inhibition by the PKC inhibitor Go6976 reduced Sp1, P3 and P4 activity and IGF-II mRNA in all three cell lines.	Tetradecanoylphorbol Acetate	113-144	insulin like growth factor 2	Homo sapiens	194-200
2509065-6	1989	Several discrepancies are observed between the hydroperoxide response to TPA and the known effects of the tumor promoter on ornithine decarboxylase (ODC) induction.	Tetradecanoylphorbol Acetate	73-76	ornithine decarboxylase, structural 1	Mus musculus	149-152
2834348-1	1987	Incubation of human promyelocytic leukemia (HL-60) cells with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a protein kinase C-activating phorbol ester, caused a marked increase in c-fos mRNA in a dose-dependent manner.	Tetradecanoylphorbol Acetate	62-99	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	180-185
2834348-1	1987	Incubation of human promyelocytic leukemia (HL-60) cells with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a protein kinase C-activating phorbol ester, caused a marked increase in c-fos mRNA in a dose-dependent manner.	Tetradecanoylphorbol Acetate	101-104	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	180-185
9780004-6	1998	PKC mediated oncogene activation of the IGF-II gene presumably through action on Sp1 since (i) PKC activation by phorbol 12-myristate 13-acetate increased Sp1 expression, P3 and P4 activity and IGF-II mRNA in control but not in oncogene-transfected cells; and (ii) PKC inhibition by the PKC inhibitor Go6976 reduced Sp1, P3 and P4 activity and IGF-II mRNA in all three cell lines.	Tetradecanoylphorbol Acetate	113-144	insulin like growth factor 2	Homo sapiens	194-200
2834348-6	1987	c-fos mRNA increased within 15 min and reached a maximal level 45 min after the stimulation of the cells by TPA or 8-Br-cAMP.	Tetradecanoylphorbol Acetate	108-111	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
2509065-7	1989	In contrast to the refractory state against ODC induction caused by TPA treatments repeated at intervals of less than 48 h, the time interval required for recovery of the hydroperoxide response to TPA in TPA-pretreated skins is only 5 h. The stimulatory effects of A23187, ionomycin and various diacylglycerols (DAGs) on hydroperoxide production do not correlate with their ODC-inducing activities.	Tetradecanoylphorbol Acetate	68-71	ornithine decarboxylase, structural 1	Mus musculus	44-47
2834348-7	1987	The simultaneous stimulation of the cells by TPA and 8-Br-cAMP at the respective doses giving maximal elevation of c-fos mRNA increased this mRNA in an additive manner.	Tetradecanoylphorbol Acetate	45-48	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	115-120
2509065-7	1989	In contrast to the refractory state against ODC induction caused by TPA treatments repeated at intervals of less than 48 h, the time interval required for recovery of the hydroperoxide response to TPA in TPA-pretreated skins is only 5 h. The stimulatory effects of A23187, ionomycin and various diacylglycerols (DAGs) on hydroperoxide production do not correlate with their ODC-inducing activities.	Tetradecanoylphorbol Acetate	197-200	ornithine decarboxylase, structural 1	Mus musculus	374-377
9710125-3	1998	In this study, we provide evidence that LOX-1 expression can be upregulated by tumor necrosis factor-alpha (TNF-alpha) and phorbol 12-myristate 13-acetate (PMA) in cultured bovine aortic endothelial cells.	Tetradecanoylphorbol Acetate	123-154	oxidized low density lipoprotein receptor 1	Bos taurus	40-45
2509065-7	1989	In contrast to the refractory state against ODC induction caused by TPA treatments repeated at intervals of less than 48 h, the time interval required for recovery of the hydroperoxide response to TPA in TPA-pretreated skins is only 5 h. The stimulatory effects of A23187, ionomycin and various diacylglycerols (DAGs) on hydroperoxide production do not correlate with their ODC-inducing activities.	Tetradecanoylphorbol Acetate	197-200	ornithine decarboxylase, structural 1	Mus musculus	374-377
2509065-9	1989	alpha-Difluoromethylornithine (DFMO) and other inhibitors of TPA-induced ODC activity fail to alter hydroperoxide production whereas the compounds that inhibit the hydroperoxide response to TPA, such as fluocinolone acetonide, have no or only minimal inhibitory activity against ODC induction.	Tetradecanoylphorbol Acetate	61-64	ornithine decarboxylase, structural 1	Mus musculus	73-76
2509065-9	1989	alpha-Difluoromethylornithine (DFMO) and other inhibitors of TPA-induced ODC activity fail to alter hydroperoxide production whereas the compounds that inhibit the hydroperoxide response to TPA, such as fluocinolone acetonide, have no or only minimal inhibitory activity against ODC induction.	Tetradecanoylphorbol Acetate	61-64	ornithine decarboxylase, structural 1	Mus musculus	279-282
2509065-12	1989	Populations of TPA-treated keratinocytes, therefore, may be responsible not only for ODC activation but also for hydroperoxide production.	Tetradecanoylphorbol Acetate	15-18	ornithine decarboxylase, structural 1	Mus musculus	85-88
2889736-6	1987	In addition to inhibiting the synthesis of these proteins, TPA greatly reduced the FSH- and Bt2cAMP-induced increase in levels of mRNA encoding the precursor form of P-450SCC.	Tetradecanoylphorbol Acetate	59-62	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	166-174
9710125-3	1998	In this study, we provide evidence that LOX-1 expression can be upregulated by tumor necrosis factor-alpha (TNF-alpha) and phorbol 12-myristate 13-acetate (PMA) in cultured bovine aortic endothelial cells.	Tetradecanoylphorbol Acetate	156-159	oxidized low density lipoprotein receptor 1	Bos taurus	40-45
3499189-1	1987	To evaluate relationships between c-fos proto-oncogene expression and specific lineages of hematopoietic differentiation we analyzed the constitutive and TPA-induced expression of the c-fos gene in a wide variety of fresh human leukemic cells.	Tetradecanoylphorbol Acetate	154-157	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	184-189
3499189-4	1987	TPA-induced c-fos expression seems to correlate with monocytoid differentiation only when sustained levels of transcripts (ie, detectable for at least 24 hours) were detected.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	12-17
2511043-3	1989	The presence of the erythroid factor in TPA-treated HEL cells in which the level of HCAI transcript has greatly decreased and in non-HCAI-expressing K562 cells suggests that in these cases the presence of the factor is not sufficient for HCAI expression.	Tetradecanoylphorbol Acetate	40-43	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	84-88
9783907-5	1998	GnRH-induced IPs desensitization was potentiated after direct activation of PKC by the phorbol ester TPA, suggesting the involvement of distinct mechanisms in the uncoupling exerted by either GnRH or TPA on GnRH-stimulated PI hydrolysis.	Tetradecanoylphorbol Acetate	101-104	gonadotropin releasing hormone 1	Mus musculus	0-4
9783907-5	1998	GnRH-induced IPs desensitization was potentiated after direct activation of PKC by the phorbol ester TPA, suggesting the involvement of distinct mechanisms in the uncoupling exerted by either GnRH or TPA on GnRH-stimulated PI hydrolysis.	Tetradecanoylphorbol Acetate	200-203	gonadotropin releasing hormone 1	Mus musculus	0-4
2518283-3	1989	The resulting Fos-Jun heterodimer can bind to the TPA-responsive element (TRE) by way of a novel, highly basic motif and can activate the transcription of TPA-responsive genes.	Tetradecanoylphorbol Acetate	50-53	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-17
2518283-3	1989	The resulting Fos-Jun heterodimer can bind to the TPA-responsive element (TRE) by way of a novel, highly basic motif and can activate the transcription of TPA-responsive genes.	Tetradecanoylphorbol Acetate	155-158	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-17
9783907-8	1998	Under GnRH desensitization conditions, TPA was still able to induce PLD activation and to further potentiate the GnRH-evoked PLD activity.	Tetradecanoylphorbol Acetate	39-42	gonadotropin releasing hormone 1	Mus musculus	6-10
9783907-8	1998	Under GnRH desensitization conditions, TPA was still able to induce PLD activation and to further potentiate the GnRH-evoked PLD activity.	Tetradecanoylphorbol Acetate	39-42	gonadotropin releasing hormone 1	Mus musculus	113-117
3664957-0	1987	Effect of butyric acid on 12-O-tetradecanoylphorbol-13-acetate-(TPA) induced mouse skin ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	26-62	ornithine decarboxylase, structural 1	Mus musculus	88-111
9671751-4	1998	Mutation of cis-elements within HS2 reveals that the tandem-binding sites for the hematopoietic-specific transcription factor NF-E2 are required for induction by TPA, and induction is conferred by expressing NF-E2 in an NF-E2-null cell line.	Tetradecanoylphorbol Acetate	162-165	spectrin beta, erythrocytic	Homo sapiens	32-35
3664957-0	1987	Effect of butyric acid on 12-O-tetradecanoylphorbol-13-acetate-(TPA) induced mouse skin ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	26-62	ornithine decarboxylase, structural 1	Mus musculus	113-116
3664957-0	1987	Effect of butyric acid on 12-O-tetradecanoylphorbol-13-acetate-(TPA) induced mouse skin ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	64-67	ornithine decarboxylase, structural 1	Mus musculus	88-111
2562220-5	1989	Ultraviolet cross-linking experiments have shown that both Fos and Jun directly contact the TGACTCA palindromic sequence defined as a TPA (12-O-tetradecanoyl phorbol-13-acetate) response element or TRE.	Tetradecanoylphorbol Acetate	134-137	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	59-62
2562220-5	1989	Ultraviolet cross-linking experiments have shown that both Fos and Jun directly contact the TGACTCA palindromic sequence defined as a TPA (12-O-tetradecanoyl phorbol-13-acetate) response element or TRE.	Tetradecanoylphorbol Acetate	139-176	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	59-62
3664957-0	1987	Effect of butyric acid on 12-O-tetradecanoylphorbol-13-acetate-(TPA) induced mouse skin ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	64-67	ornithine decarboxylase, structural 1	Mus musculus	113-116
9674706-4	1998	PMA treatment of the u-PAR-deficient OVCAR-3 ovarian cancer cells, which contain low JNK activities, resulted in a rapid (5 min) increase in JNK activity.	Tetradecanoylphorbol Acetate	0-3	plasminogen activator, urokinase receptor	Homo sapiens	21-26
3664957-3	1987	It was found that butyric acid inhibited the TPA-induced mouse skin ODC activity.	Tetradecanoylphorbol Acetate	45-48	ornithine decarboxylase, structural 1	Mus musculus	68-71
9662163-2	1998	K- and TNK-tPA are more fibrin-specific than rt-PA, and are also resistant to inactivation by plasminogen activator inhibitor-1 (PAI-1).	Tetradecanoylphorbol Acetate	11-14	serpin family E member 1	Homo sapiens	94-127
3499311-4	1987	TPA increased forskolin-stimulated 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) 2-fold, while depressing forskolin-stimulated 17 c-hydroxylase to basal values DHEA sulfotransferase increased 3-fold on transfer of human adrenocortical cells from serum-containing to defined, serum-free medium; TPA inhibited this increase.	Tetradecanoylphorbol Acetate	0-3	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	72-82
2482225-4	1989	AP-2 also has been proposed to confer TPA and cAMP inducibility on promoters/enhancers containing AP-2-binding sites.	Tetradecanoylphorbol Acetate	38-41	transcription factor AP-2 alpha	Homo sapiens	0-4
2482225-4	1989	AP-2 also has been proposed to confer TPA and cAMP inducibility on promoters/enhancers containing AP-2-binding sites.	Tetradecanoylphorbol Acetate	38-41	transcription factor AP-2 alpha	Homo sapiens	98-102
2482225-7	1989	In fact, AP-2 mRNA is repressed by both TPA and the calcium ionophore A23187 through a delayed response.	Tetradecanoylphorbol Acetate	40-43	transcription factor AP-2 alpha	Homo sapiens	9-13
9662163-2	1998	K- and TNK-tPA are more fibrin-specific than rt-PA, and are also resistant to inactivation by plasminogen activator inhibitor-1 (PAI-1).	Tetradecanoylphorbol Acetate	11-14	serpin family E member 1	Homo sapiens	129-134
2482225-8	1989	These data suggest that the AP-2-binding site-mediated cAMP and TPA responses are not regulated at the level of AP-2 expression but, rather, achieved either by post-translational changes in AP-2 or in conjunction with another protein.	Tetradecanoylphorbol Acetate	64-67	transcription factor AP-2 alpha	Homo sapiens	28-32
2820703-7	1987	Diacylglycerol and protein kinase C may play a role in this process, since dioctanoylglycerol (10(-4) M) and 12-O-tetradecanoyl phorbol 13-acetate (10(-6) M) each enhance PTH release from permeabilized cells 2- to 4-fold at a Ca2+ concentration (approximately 2 X 10(-7) M) equivalent to that present in the intact cell at low extracellular Ca2+ concentrations.	Tetradecanoylphorbol Acetate	109-146	parathyroid hormone	Bos taurus	171-174
9701026-3	1998	Furthermore, Go 6976 and GF 109203X abrogated phorbol myristate acetate-induced inhibition of anti-CD95-induced apoptosis.	Tetradecanoylphorbol Acetate	46-71	Fas cell surface death receptor	Homo sapiens	99-103
2556070-4	1989	Our results represent the first induction of KRAS gene rearrangement in cells of patients with familiar polyposis coli (FPC) treated with N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) and 12-0-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	225-228	KRAS proto-oncogene, GTPase	Homo sapiens	45-49
9684803-0	1998	Human thrombin and calcium bound factor Xa significantly shorten tPA-induced fibrin clot lysis time via neutralization of plasminogen activator inhibitor type 1 activity.	Tetradecanoylphorbol Acetate	65-68	serpin family E member 1	Homo sapiens	122-160
2550470-5	1989	However, the reactivated viral K-ras protein strongly increased the stimulability of membrane-associated PKC by TPA and it further increased TPA"s ability to enhance the responsiveness of adenylate cyclase to IPR and PGE1.	Tetradecanoylphorbol Acetate	112-115	KRAS proto-oncogene, GTPase	Homo sapiens	31-36
2550470-5	1989	However, the reactivated viral K-ras protein strongly increased the stimulability of membrane-associated PKC by TPA and it further increased TPA"s ability to enhance the responsiveness of adenylate cyclase to IPR and PGE1.	Tetradecanoylphorbol Acetate	141-144	KRAS proto-oncogene, GTPase	Homo sapiens	31-36
3116077-0	1987	Phosphorylation of the CD8 antigen on cytotoxic human T cells in response to phorbol myristate acetate or antigen-presenting B cells.	Tetradecanoylphorbol Acetate	77-102	CD8a molecule	Homo sapiens	23-26
3116077-3	1987	CD8 undergoes rapid and intense phosphorylation in serine upon addition of phorbol myristate acetate to the cells.	Tetradecanoylphorbol Acetate	75-100	CD8a molecule	Homo sapiens	0-3
9684803-5	1998	Fibrin autography revealed that both enzymes dose dependently interfered with complex formation between tPA and PAI-1, making large amounts of tPA remaining to be free form.	Tetradecanoylphorbol Acetate	104-107	serpin family E member 1	Homo sapiens	112-117
9684803-5	1998	Fibrin autography revealed that both enzymes dose dependently interfered with complex formation between tPA and PAI-1, making large amounts of tPA remaining to be free form.	Tetradecanoylphorbol Acetate	143-146	serpin family E member 1	Homo sapiens	112-117
2570112-8	1989	Optimal doses of CsA inhibited TPA-induced ODC activity, TGase activity, arachidonic acid release, and interleukin-1 beta (IL-1 beta) mRNA to the same degree (approximately 80%), despite measurement at widely different times (30 min-12 h) required to obtain maximal induction by TPA.	Tetradecanoylphorbol Acetate	31-34	ornithine decarboxylase, structural 1	Mus musculus	43-46
9632700-2	1998	The secretagogue bombesin, the protein kinase C activator phorbol 12-myristate 13-acetate (PMA), and the protein-tyrosine phosphatase inhibitor pervanadate induced tyrosine phosphorylation of different proteins, including paxillin and p125(FAK), which was reduced or blocked by the tyrosine kinase inhibitors genistein and tyrphostin B56, respectively.	Tetradecanoylphorbol Acetate	58-89	protein tyrosine kinase 2	Rattus norvegicus	240-243
2472874-9	1989	The results of this experiment indicated that elevated levels of Ha-ras-specific RNA, in comparison with normal epidermal RNA, were present in papillomas and carcinomas from DMBA-initiated, TPA-promoted mice irrespective of the diet the mice were fed.	Tetradecanoylphorbol Acetate	190-193	Harvey rat sarcoma virus oncogene	Mus musculus	65-71
3119989-0	1987	c-fos sequence necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate and the calcium ionophore.	Tetradecanoylphorbol Acetate	88-125	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
3119989-1	1987	We have investigated the sequence requirements for induction of the human c-fos gene by epidermal growth factor (EGF), 12-O-tetradecanoyl-13-acetate (TPA), and the calcium ionophore A23187 by transfecting c-fos promoter mutants into HeLa and A431 cells.	Tetradecanoylphorbol Acetate	150-153	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-79
9632700-2	1998	The secretagogue bombesin, the protein kinase C activator phorbol 12-myristate 13-acetate (PMA), and the protein-tyrosine phosphatase inhibitor pervanadate induced tyrosine phosphorylation of different proteins, including paxillin and p125(FAK), which was reduced or blocked by the tyrosine kinase inhibitors genistein and tyrphostin B56, respectively.	Tetradecanoylphorbol Acetate	91-94	protein tyrosine kinase 2	Rattus norvegicus	240-243
2506060-1	1989	The monoclonal antibody HC1/6 generated against phorbol 12-myristate 13-acetate-treated U-937 cells recognizes a new cell surface antigen with a broad relative molecular mass ranging from 100 to 150 kDa.	Tetradecanoylphorbol Acetate	48-79	CYCS pseudogene 39	Homo sapiens	24-29
9548719-3	1998	We found that in MDCK epithelial cells, MBS accumulated at the tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling area, where moesin, a member of the ERM (ezrin, radixin, and moesin) family, was localized.	Tetradecanoylphorbol Acetate	96-99	moesin	Canis lupus familiaris	139-145
2506060-5	1989	The expression of the HC1/6 antigen is increased up to 5-fold when U-937 (promonocytic) and HL-60 (myelomonocytic) cell lines are stimulated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	146-177	CYCS pseudogene 39	Homo sapiens	22-27
2769233-2	1989	We have analysed the effect of IFN-alpha/beta on the respiratory burst capacity of mouse peritoneal macrophages by luminol-dependent chemiluminescence using phorbol myristate acetate as trigger.	Tetradecanoylphorbol Acetate	157-182	interferon alpha	Mus musculus	31-40
2442256-5	1987	Inhibition of anti-Ig/Sepharose-induced mitogenesis by pretreatment of the cells with phorbol-12-myristate-13-acetate was associated with a specific inhibition (63%) of p40/pI-5.	Tetradecanoylphorbol Acetate	86-117	interleukin 9	Mus musculus	169-177
9508799-11	1998	Addition of purified PKC to the pipette solution, followed by a pretreatment with TPA, reduced the rate of ICl(swell) activation in human Pgp- and mouse Pgp1a-expressing CHO cells to the levels observed in parental and mouse Pgp1b-expressing cells.	Tetradecanoylphorbol Acetate	82-85	phosphoglycolate phosphatase	Homo sapiens	138-141
3477548-10	1987	Likewise, ODC levels are decreased in the 21.1 cells after exposure to PMA even though PMA only slightly modulates the growth of these cells.	Tetradecanoylphorbol Acetate	71-74	ornithine decarboxylase, structural 1	Mus musculus	10-13
3498728-5	1987	Under the same conditions, TPA decreased the level of muscular alpha-actin mRNA and increased that of nonmuscular beta- and gamma-actins mRNA.	Tetradecanoylphorbol Acetate	27-30	actin, alpha 2, smooth muscle, aorta	Gallus gallus	63-74
2813854-6	1989	Administration of phorbol ester (PMA 10-100 nM, a PK-C activator) alone significantly provoked gastrin release, but markedly inhibited the BBS (1 nM) stimulated gastrin secretion in a dose-dependent manner.	Tetradecanoylphorbol Acetate	33-36	gastrin	Rattus norvegicus	95-102
9535820-8	1998	Lastly, we observed that the use of the MEK1 inhibitor PD98059 inhibited TPA-mediated ERK activity and abrogated the anti-apoptotic effects of TPA.	Tetradecanoylphorbol Acetate	73-76	mitogen-activated protein kinase kinase 1	Homo sapiens	40-44
2813854-6	1989	Administration of phorbol ester (PMA 10-100 nM, a PK-C activator) alone significantly provoked gastrin release, but markedly inhibited the BBS (1 nM) stimulated gastrin secretion in a dose-dependent manner.	Tetradecanoylphorbol Acetate	33-36	gastrin	Rattus norvegicus	161-168
3329719-2	1987	c-fos and c-myc oncogenes expression was measured in these cells after addition of their specific growth factor TSH and after treatment with either forskolin, an activator of adenylate cyclase or with a tumor promoter, TPA.	Tetradecanoylphorbol Acetate	219-222	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
9535820-8	1998	Lastly, we observed that the use of the MEK1 inhibitor PD98059 inhibited TPA-mediated ERK activity and abrogated the anti-apoptotic effects of TPA.	Tetradecanoylphorbol Acetate	143-146	mitogen-activated protein kinase kinase 1	Homo sapiens	40-44
9575800-7	1998	However, protein kinase C (PKC) levels were downregulated in TPA-treated cells but not in alpha qQ209L-expressing cells, suggesting that the regulation of PKC by G alpha q may be different from regulation by TPA.	Tetradecanoylphorbol Acetate	61-64	G protein subunit alpha q	Homo sapiens	162-171
2820405-1	1987	NADPH-cytochrome c reductase and cytochrome b559 were purified from the membrane fraction of phorbol myristate acetate-stimulated porcine polymorphonuclear leukocytes.	Tetradecanoylphorbol Acetate	93-118	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
2759229-0	1989	Direct evidence that the kinase activity of protein kinase C is involved in transcriptional activation through a TPA-responsive element.	Tetradecanoylphorbol Acetate	113-116	protein kinase C, gamma	Rattus norvegicus	44-60
2759229-1	1989	In order to examine the involvement of protein kinase C (PKC) in the transcriptional activation of genes by TPA (12-0-tetradecanoyl phorbol 13-acetate) we have constructed a series of PKC expression plasmids.	Tetradecanoylphorbol Acetate	108-111	protein kinase C, gamma	Rattus norvegicus	39-55
9516131-4	1998	Treatment of EC with GAS6 significantly inhibited adhesion of polymorphonuclear cells (PMN) induced by phorbol 12-myristate 13-acetate (PMA), platelet-activating factor (PAF), thrombin, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), but not that induced by FMLP and IL-8.	Tetradecanoylphorbol Acetate	103-134	growth arrest specific 6	Homo sapiens	21-25
2759229-1	1989	In order to examine the involvement of protein kinase C (PKC) in the transcriptional activation of genes by TPA (12-0-tetradecanoyl phorbol 13-acetate) we have constructed a series of PKC expression plasmids.	Tetradecanoylphorbol Acetate	108-111	protein kinase C, gamma	Rattus norvegicus	57-60
2759229-1	1989	In order to examine the involvement of protein kinase C (PKC) in the transcriptional activation of genes by TPA (12-0-tetradecanoyl phorbol 13-acetate) we have constructed a series of PKC expression plasmids.	Tetradecanoylphorbol Acetate	108-111	protein kinase C, gamma	Rattus norvegicus	184-187
2759229-2	1989	Transient expression of an active fragment of PKC in rat fibroblasts resulted in the transcriptional activation of a TRE (TPA-responsive element)-CAT chimeric gene which contains various repetitions of collagenase TREs.	Tetradecanoylphorbol Acetate	122-125	protein kinase C, gamma	Rattus norvegicus	46-49
2759229-3	1989	These provide the first direct evidence that kinase activity of PKC is involved in TPA-induced transcriptional activation through TRE.	Tetradecanoylphorbol Acetate	83-86	protein kinase C, gamma	Rattus norvegicus	64-67
2759232-3	1989	Moreover, we have shown for the first time that this kinase or a kinase that coeluted from the column with PKC could be activated by a phorbol ester, PMA, in a phospholipid-free system, i.e. in the absence of any cofactor of PKC.	Tetradecanoylphorbol Acetate	150-153	protein kinase C, gamma	Rattus norvegicus	107-110
2820405-1	1987	NADPH-cytochrome c reductase and cytochrome b559 were purified from the membrane fraction of phorbol myristate acetate-stimulated porcine polymorphonuclear leukocytes.	Tetradecanoylphorbol Acetate	93-118	mitochondrially encoded cytochrome b	Homo sapiens	33-45
3306603-4	1987	The reduction in ADA enzymatic activity is preceded by a 5-10 fold reduction in ADA-specific mRNA which is also more rapid during TPA-induced differentiation.	Tetradecanoylphorbol Acetate	130-133	adenosine deaminase	Homo sapiens	17-20
3306603-4	1987	The reduction in ADA enzymatic activity is preceded by a 5-10 fold reduction in ADA-specific mRNA which is also more rapid during TPA-induced differentiation.	Tetradecanoylphorbol Acetate	130-133	adenosine deaminase	Homo sapiens	80-83
2759232-3	1989	Moreover, we have shown for the first time that this kinase or a kinase that coeluted from the column with PKC could be activated by a phorbol ester, PMA, in a phospholipid-free system, i.e. in the absence of any cofactor of PKC.	Tetradecanoylphorbol Acetate	150-153	protein kinase C, gamma	Rattus norvegicus	225-228
9745617-8	1998	Western immunoblot analysis of cyclins (A, B1, D1 and E) and p27Kip1, a cyclin-dependent kinase inhibitor, indicated that TPA induced cyclin A and cyclin B1 expression in P+ (but not in P-) JB6 cells and this induction coincided in time with TPA-induced synthesis of DNA.	Tetradecanoylphorbol Acetate	122-125	cyclin dependent kinase inhibitor 1B	Homo sapiens	61-68
9561912-10	1998	More significantly, they express constitutively the c-fms (the receptor of the macrophage growth factor) and, under TPA stimulation, are able to modulate the expression of this receptor and its ligand, as well as TNF-alpha and IL-1.	Tetradecanoylphorbol Acetate	116-119	interleukin 1 alpha	Homo sapiens	227-231
2500437-5	1989	On stimulation, the relative increases in AAG (approximately 4-fold, fMet-Leu-Phe; approximately 20-fold, PMA and A23187) were much greater than the corresponding relative increases in the levels of DAG (approximately 2-fold fMet-Leu-Phe; approximately 5-fold, PMA and A23187).	Tetradecanoylphorbol Acetate	106-109	N-methylpurine DNA glycosylase	Homo sapiens	42-45
2478116-8	1989	Agents which act directly on protein kinase C (phorbol myristate acetate) also stimulate C1-inh synthesis.	Tetradecanoylphorbol Acetate	47-72	serpin family G member 1	Homo sapiens	89-95
3112228-6	1987	In cultures of resident peritoneal macrophages, phorbol myristate acetate and cholera toxin increase the synthesis of the Mr 55,000 secreted PAI, whereas dexamethasone decreases the synthesis of both PAI; the production of PAI is also enhanced in the presence of macrophage colony-stimulating factor (CSF-1).	Tetradecanoylphorbol Acetate	48-73	colony stimulating factor 1 (macrophage)	Mus musculus	301-306
9555062-0	1998	The stimulation of rat astrocytes with phorbol-12-myristate-13-acetate increases the proenkephalin mRNA: involvement of proto-oncogenes.	Tetradecanoylphorbol Acetate	39-70	proenkephalin	Rattus norvegicus	85-98
9555062-1	1998	The effect of phorbol-12-myristate-13-acetate (PMA) on the regulation of proenkephalin (proENK) mRNA level, ENKCRE-2 or AP-1 DNA binding activity, and the mRNA and protein levels of proto-oncogenes (c-fos, fra-1, and c-jun) in primary cultured rat astrocytes were studied.	Tetradecanoylphorbol Acetate	47-50	proenkephalin	Rattus norvegicus	73-86
2665839-9	1989	On the other hand, PMA inhibited growth of CMK cells and induced most of them to express the GPIIb/IIIa antigen.	Tetradecanoylphorbol Acetate	19-22	integrin subunit alpha 2b	Homo sapiens	93-98
9555062-3	1998	Both AP-1 and ENKCRE-2 DNA binding activities were markedly increased at 1-4 h by PMA treatment and these PMA-induced responses were inhibited by pre-treatment with CHX, showing that the increase of proENK mRNA level was well correlated with the AP-1 and ENKCRE-2 DNA binding activities.	Tetradecanoylphorbol Acetate	82-85	proenkephalin	Rattus norvegicus	199-205
3614203-2	1987	Stimulation of quiescent BALB/c 3T3 mouse fibroblasts with purified fibroblast and platelet-derived growth factors and with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate results in a rapid and dramatic increase in ODC mRNA, similar to the increase caused by serum stimulation.	Tetradecanoylphorbol Acetate	143-179	ornithine decarboxylase, structural 1	Mus musculus	224-227
9555062-3	1998	Both AP-1 and ENKCRE-2 DNA binding activities were markedly increased at 1-4 h by PMA treatment and these PMA-induced responses were inhibited by pre-treatment with CHX, showing that the increase of proENK mRNA level was well correlated with the AP-1 and ENKCRE-2 DNA binding activities.	Tetradecanoylphorbol Acetate	106-109	proenkephalin	Rattus norvegicus	199-205
2544313-9	1989	TPA-caused epidermal ornithine decarboxylase (ODC) induction was not inhibited by staurosporine but rather augmented by this agent.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	21-44
9559896-16	1998	Whilst phorbol-12-myristate-13-acetate (PMA; 3 microg ml(-1)) and 10% foetal bovine serum (positive control agents) significantly stimulated the release of both MMP-1 and PGE2 from CEPI cells, BK (0.1 nM-10 microM) was without any significant effect under these conditions.	Tetradecanoylphorbol Acetate	7-38	matrix metallopeptidase 1	Homo sapiens	161-166
2544313-9	1989	TPA-caused epidermal ornithine decarboxylase (ODC) induction was not inhibited by staurosporine but rather augmented by this agent.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	46-49
2544313-13	1989	It is possible that TPA induces inflammation, ODC activity, epidermal hyperplasia and tumor promotion through the activation of different type(s) of protein kinase C and staurosporine inhibits only certain type(s) of protein kinase C. Another possible explanation is that the protein kinase C inhibition by staurosporine depends on the nature of the substrate proteins or the intracellular localization of the enzyme.	Tetradecanoylphorbol Acetate	20-23	ornithine decarboxylase, structural 1	Mus musculus	46-49
3037776-0	1987	Enhancement of Epstein-Barr virus membrane protein (LMP) expression by serum, TPA, or n-butyrate in latently infected Raji cells.	Tetradecanoylphorbol Acetate	78-81	PDZ and LIM domain 7	Homo sapiens	52-55
3495533-2	1987	PMA, carbachol, and EGF all stimulated rapid accumulation of mRNA for the proto-oncogenes c-fos and c-myc in the normal cells; in the protein kinase C-deficient cells, carbachol and EGF, but not PMA, retained this effect, which was not mimicked by the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-95
9559896-16	1998	Whilst phorbol-12-myristate-13-acetate (PMA; 3 microg ml(-1)) and 10% foetal bovine serum (positive control agents) significantly stimulated the release of both MMP-1 and PGE2 from CEPI cells, BK (0.1 nM-10 microM) was without any significant effect under these conditions.	Tetradecanoylphorbol Acetate	40-43	matrix metallopeptidase 1	Homo sapiens	161-166
2788092-2	1989	Here we show that IL4 and phorbol 12-myristate 13-acetate (PMA) induce, on a per cell basis, very high IgE secretion in purified human B cells by using a mouse thymoma (EL4) co-culture method.	Tetradecanoylphorbol Acetate	26-57	epilepsy 4	Mus musculus	169-172
2788092-2	1989	Here we show that IL4 and phorbol 12-myristate 13-acetate (PMA) induce, on a per cell basis, very high IgE secretion in purified human B cells by using a mouse thymoma (EL4) co-culture method.	Tetradecanoylphorbol Acetate	59-62	epilepsy 4	Mus musculus	169-172
3108444-4	1987	Similar kinetics of c-fos gene activation was also observed when cells were treated with PMA or sn-1,2-dioctanoylglycerol, but not with the calcium mobilizer ionomycin, suggesting a role for protein kinase C in gene regulation by chemoattractant receptors.	Tetradecanoylphorbol Acetate	89-92	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-25
9593585-6	1998	Growth arrest of HL-60 cells, caused by 10 nM phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced monocytic/macrophage-like differentiation for 72 hrs., has been accompanied by a 50% decrease in UBF1/2 mRNAs expression.	Tetradecanoylphorbol Acetate	98-101	upstream binding transcription factor	Homo sapiens	208-214
2777906-1	1989	Myelin basic protein, an 80-kilodalton (kDa) protein in rat oligodendrocytes, and an 80-kDa basic protein in neuroblastoma x neonatal Chinese hamster brain explant hybrids were phosphorylated extensively when the cells were treated with either phorbol esters (TPA) or diacylglycerols (e.g., oleyoyl-acetylglycerol).	Tetradecanoylphorbol Acetate	260-263	myelin basic protein	Rattus norvegicus	0-20
2504935-4	1989	In contrast, of the three effectors studied, only TPA induced transcription of the proto-oncogene c-fos, studied as a control gene responsive to various stimuli, and induced a rapid increase in urokinase-type PA (u-PA).	Tetradecanoylphorbol Acetate	50-53	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-103
3294900-5	1987	Furthermore, rGM-CSF was observed to significantly enhance TNF secretion by monocytes stimulated with endotoxin and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	116-141	colony stimulating factor 2	Rattus norvegicus	13-20
9464999-7	1998	Given the rapid Abeta turnover rate, acute studies were designed using phorbol 12-myristate 13-acetate (PMA), which had been demonstrated previously to reduce Abeta secretion from cells in vitro via induction of protein kinase C (PKC) activity.	Tetradecanoylphorbol Acetate	71-102	amyloid beta (A4) precursor protein	Mus musculus	159-164
3294900-5	1987	Furthermore, rGM-CSF was observed to significantly enhance TNF secretion by monocytes stimulated with endotoxin and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	143-146	colony stimulating factor 2	Rattus norvegicus	13-20
3581045-5	1987	The inhibition of TPA action was shown not to be restricted to DNA synthesis in 3T3 cultured cells since the sialoglycopeptide also inhibited TPA-induced ornithine decarboxylase (ODC, L-ornithine carboxylase, EC 4.1.1.17) activation in suspensions of mouse epidermal and 3T3 cells.	Tetradecanoylphorbol Acetate	142-145	ornithine decarboxylase, structural 1	Mus musculus	154-177
2684368-2	1989	Adult T-cell Leukemia cell lines MT-1, MT-2, KH-2 and MT-2 stimulated by phorbol 12-myristate 13-acetate (PMA) were used as target cells in immunofluorescence microscopy (IF) examination with positive rates as 0.20% (2/965), 0.62% (6/965), 0.20% (2/965) and 0.51 (5/965) respectively.	Tetradecanoylphorbol Acetate	73-104	potassium voltage-gated channel modifier subfamily G member 1	Homo sapiens	45-49
2684368-2	1989	Adult T-cell Leukemia cell lines MT-1, MT-2, KH-2 and MT-2 stimulated by phorbol 12-myristate 13-acetate (PMA) were used as target cells in immunofluorescence microscopy (IF) examination with positive rates as 0.20% (2/965), 0.62% (6/965), 0.20% (2/965) and 0.51 (5/965) respectively.	Tetradecanoylphorbol Acetate	106-109	potassium voltage-gated channel modifier subfamily G member 1	Homo sapiens	45-49
2742593-5	1989	Both phorbol myristate acetate (PMA) and Mezerein, a non-phorbol which also stimulates PKC, enhanced both the expression of ICAM 1 on HUVEC and the adherence of HUVEC for PMN.	Tetradecanoylphorbol Acetate	5-30	intercellular adhesion molecule 1	Homo sapiens	124-130
2742593-5	1989	Both phorbol myristate acetate (PMA) and Mezerein, a non-phorbol which also stimulates PKC, enhanced both the expression of ICAM 1 on HUVEC and the adherence of HUVEC for PMN.	Tetradecanoylphorbol Acetate	32-35	intercellular adhesion molecule 1	Homo sapiens	124-130
3581045-5	1987	The inhibition of TPA action was shown not to be restricted to DNA synthesis in 3T3 cultured cells since the sialoglycopeptide also inhibited TPA-induced ornithine decarboxylase (ODC, L-ornithine carboxylase, EC 4.1.1.17) activation in suspensions of mouse epidermal and 3T3 cells.	Tetradecanoylphorbol Acetate	142-145	ornithine decarboxylase, structural 1	Mus musculus	179-182
9464999-7	1998	Given the rapid Abeta turnover rate, acute studies were designed using phorbol 12-myristate 13-acetate (PMA), which had been demonstrated previously to reduce Abeta secretion from cells in vitro via induction of protein kinase C (PKC) activity.	Tetradecanoylphorbol Acetate	104-107	amyloid beta (A4) precursor protein	Mus musculus	159-164
3495445-5	1987	Stimulation of B lymphocytes with TPA plus ionomycin resulted in increased magnitude and a shift in the kinetics of c-fos and c-myc expression compared with either agent used alone.	Tetradecanoylphorbol Acetate	34-37	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-121
9525834-3	1998	However, MIP-1alpha production was increased in three cell lines by stimulation with lipopolysaccharide (LPS) and 5 cell lines by stimulation with phorbol-12myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	147-177	C-C motif chemokine ligand 3	Homo sapiens	9-19
3579940-1	1987	Ornithine decarboxylase (ODC) was induced in the liver, lung and brain of the mouse injected intraperitoneally with 12-O-tetradecanoylphorbol 13-acetate (TPA), showing maximal enzyme activity four hours after the injection.	Tetradecanoylphorbol Acetate	116-152	ornithine decarboxylase, structural 1	Mus musculus	0-23
3579940-1	1987	Ornithine decarboxylase (ODC) was induced in the liver, lung and brain of the mouse injected intraperitoneally with 12-O-tetradecanoylphorbol 13-acetate (TPA), showing maximal enzyme activity four hours after the injection.	Tetradecanoylphorbol Acetate	116-152	ornithine decarboxylase, structural 1	Mus musculus	25-28
2655888-2	1989	Enhanced expression of c-sis mRNA was induced by phorbol ester (PMA) and diacylglycerol, each of which activates protein kinase C. c-sis mRNA was also induced by transforming growth factor beta (TGF-beta).	Tetradecanoylphorbol Acetate	64-67	platelet derived growth factor subunit B	Homo sapiens	23-28
9525834-3	1998	However, MIP-1alpha production was increased in three cell lines by stimulation with lipopolysaccharide (LPS) and 5 cell lines by stimulation with phorbol-12myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	179-182	C-C motif chemokine ligand 3	Homo sapiens	9-19
3579940-1	1987	Ornithine decarboxylase (ODC) was induced in the liver, lung and brain of the mouse injected intraperitoneally with 12-O-tetradecanoylphorbol 13-acetate (TPA), showing maximal enzyme activity four hours after the injection.	Tetradecanoylphorbol Acetate	154-157	ornithine decarboxylase, structural 1	Mus musculus	0-23
3579940-1	1987	Ornithine decarboxylase (ODC) was induced in the liver, lung and brain of the mouse injected intraperitoneally with 12-O-tetradecanoylphorbol 13-acetate (TPA), showing maximal enzyme activity four hours after the injection.	Tetradecanoylphorbol Acetate	154-157	ornithine decarboxylase, structural 1	Mus musculus	25-28
9666341-12	1998	Similar to the effects of AVP, PMA inhibited cAMP-stimulated testosterone production and P450c17 mRNA expression.	Tetradecanoylphorbol Acetate	31-34	cytochrome P450, family 17, subfamily a, polypeptide 1	Mus musculus	89-96
3579940-3	1987	The induction of ODC activity by TPA was specifically blocked by methylglyoxal bis(butylamidinohydrazone) (MGBB), a competitive inhibitor of ODC and S-adenosylmethionine decarboxylase, but not by the analog methylglyoxal bis(guanylhydrazone) (MGBG).	Tetradecanoylphorbol Acetate	33-36	ornithine decarboxylase, structural 1	Mus musculus	17-20
3579940-3	1987	The induction of ODC activity by TPA was specifically blocked by methylglyoxal bis(butylamidinohydrazone) (MGBB), a competitive inhibitor of ODC and S-adenosylmethionine decarboxylase, but not by the analog methylglyoxal bis(guanylhydrazone) (MGBG).	Tetradecanoylphorbol Acetate	33-36	ornithine decarboxylase, structural 1	Mus musculus	141-144
3469021-0	1987	12-O-tetradecanoylphorbol-13-acetate-dependent induction of xanthine dehydrogenase and conversion to xanthine oxidase in murine epidermis.	Tetradecanoylphorbol Acetate	0-36	xanthine dehydrogenase	Mus musculus	60-82
2670560-7	1989	This stimulation could be mimicked by TPA, suggesting that the action could be mediated through activation of protein kinase C. Furthermore, addition of MGSA to the endothelial cell cultures induces gro/MGSA gene expression, implying that an autocrine mechanism exists.	Tetradecanoylphorbol Acetate	38-41	C-X-C motif chemokine ligand 1	Homo sapiens	153-157
2666144-7	1989	Pgp-1hi and Pgp-1lo T cells from young mice proliferate equally well when stimulated by optimal doses of phorbol myristate acetate and ionomycin suggesting that the poor responses to concanavalin A do not simply reflect low viability.	Tetradecanoylphorbol Acetate	105-130	CD44 antigen	Mus musculus	0-5
9467952-5	1998	Inhibition of the Erk2 pathway by PD98059, specific for the upstream MAP kinase kinase (MEK1), abolishes TPA-stimulated junB but not insulin-induced c-jun.	Tetradecanoylphorbol Acetate	105-108	mitogen-activated protein kinase kinase 1	Homo sapiens	88-92
9438385-8	1998	TPA inhibited Taxol-mediated activation of p34cdc2 kinase by preventing the dephosphorylation of the Tyr-15 residue on p34cdc2 without altering the levels of Cdc2 and cyclin B1.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase 1	Homo sapiens	43-50
2484077-11	1989	Phorbol-12-myristate-13-acetate (PMA, 30-300 nM), a direct activator of PK-C, significantly enhanced the EJP amplitude after 40 min in a concentration-dependent manner, without affecting the resting potential of the VSM cells.	Tetradecanoylphorbol Acetate	0-31	Prkca	Cavia porcellus	72-76
2484077-11	1989	Phorbol-12-myristate-13-acetate (PMA, 30-300 nM), a direct activator of PK-C, significantly enhanced the EJP amplitude after 40 min in a concentration-dependent manner, without affecting the resting potential of the VSM cells.	Tetradecanoylphorbol Acetate	33-36	Prkca	Cavia porcellus	72-76
3469021-0	1987	12-O-tetradecanoylphorbol-13-acetate-dependent induction of xanthine dehydrogenase and conversion to xanthine oxidase in murine epidermis.	Tetradecanoylphorbol Acetate	0-36	xanthine dehydrogenase	Mus musculus	101-117
3032995-0	1987	Effects of diverse intracellular thiol delivery agents on glutathione peroxidase activity, the ratio of reduced/oxidized glutathione, and ornithine decarboxylase induction in isolated mouse epidermal cells treated with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	219-255	ornithine decarboxylase, structural 1	Mus musculus	138-161
3032995-3	1987	Moreover, diethyldithiocarbamate prevents totally the initial drop in the GSH/GSSG ratio of TPA-treated cells and is the most potent inhibitor of TPA-decreased GSH peroxidase activity in relation with its remarkable 98% inhibition of TPA-induced ODC activity, suggesting that the potential antitumor-promoting activity of this compound in mouse skin may be far superior to that previously demonstrated by GSH in the initiation-promotion protocol.	Tetradecanoylphorbol Acetate	92-95	ornithine decarboxylase, structural 1	Mus musculus	246-249
9438385-8	1998	TPA inhibited Taxol-mediated activation of p34cdc2 kinase by preventing the dephosphorylation of the Tyr-15 residue on p34cdc2 without altering the levels of Cdc2 and cyclin B1.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase 1	Homo sapiens	119-126
3032995-3	1987	Moreover, diethyldithiocarbamate prevents totally the initial drop in the GSH/GSSG ratio of TPA-treated cells and is the most potent inhibitor of TPA-decreased GSH peroxidase activity in relation with its remarkable 98% inhibition of TPA-induced ODC activity, suggesting that the potential antitumor-promoting activity of this compound in mouse skin may be far superior to that previously demonstrated by GSH in the initiation-promotion protocol.	Tetradecanoylphorbol Acetate	146-149	ornithine decarboxylase, structural 1	Mus musculus	246-249
2547133-12	1989	TPA-induced ornithine decarboxylase (ODC) was significantly higher in AA-treated cultures compared to EPA-treated cultures.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	12-35
3032995-3	1987	Moreover, diethyldithiocarbamate prevents totally the initial drop in the GSH/GSSG ratio of TPA-treated cells and is the most potent inhibitor of TPA-decreased GSH peroxidase activity in relation with its remarkable 98% inhibition of TPA-induced ODC activity, suggesting that the potential antitumor-promoting activity of this compound in mouse skin may be far superior to that previously demonstrated by GSH in the initiation-promotion protocol.	Tetradecanoylphorbol Acetate	146-149	ornithine decarboxylase, structural 1	Mus musculus	246-249
2547133-12	1989	TPA-induced ornithine decarboxylase (ODC) was significantly higher in AA-treated cultures compared to EPA-treated cultures.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	37-40
9438386-8	1998	These findings demonstrate that stimulation of basal epidermal cells by 12-O-tetradecanoylphorbol-13-acetate results in several classic cell cycle events and suggests that p57Kip2 plays a key role in regulating proliferation in the epidermis.	Tetradecanoylphorbol Acetate	72-108	cyclin-dependent kinase inhibitor 1C (P57)	Mus musculus	172-179
9609459-4	1998	Semiquantitative PCR showed that phorbol myristate acetate (100 nM) increased the ratio of PCR products for MCP-1 to housekeeping gene glyceraldehyde-3-phosphate dehydrogenase on densitometric results at 24 h by 2.7-fold, which was prevented by calphostin C (200 nM) pretreatment.	Tetradecanoylphorbol Acetate	33-58	C-C motif chemokine ligand 2	Homo sapiens	108-113
2747640-2	1989	We found that SAA mRNA could be increased fivefold in transfected cells by treatment with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	90-121	serum amyloid A1 cluster	Homo sapiens	14-17
2747640-2	1989	We found that SAA mRNA could be increased fivefold in transfected cells by treatment with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	123-126	serum amyloid A1 cluster	Homo sapiens	14-17
3029099-1	1987	HeLa cells synthesize and secrete increased levels of tissue plasminogen activator (tPA) when incubated for 18 h with 10-20 nM phorbol myristate acetate.	Tetradecanoylphorbol Acetate	127-152	chromosome 20 open reading frame 181	Homo sapiens	84-87
3029099-9	1987	Phorbol myristate acetate, 5-20 nM, increased Na+/K+-ATPase activity up to 2-fold and tPA secretion up to 15-fold.	Tetradecanoylphorbol Acetate	0-25	chromosome 20 open reading frame 181	Homo sapiens	86-89
10063971-7	1998	We also explored the PKC mechanism(s) responsible for the synergism of TPA and gemcitabine, and determined that treatment with 10 nM TPA for 24 h in BG-1 cells: 1) downregulated PKCdelta and PKCalpha, without affecting PKCepsilon, 2) did not affect cell cycle distribution into S phase.	Tetradecanoylphorbol Acetate	133-136	protein kinase C epsilon	Homo sapiens	219-229
3029099-10	1987	We conclude that the secretion of tPA by HeLa cells treated with phorbol myristate acetate proceeds via a mechanism which requires extracellular Na+ and a functional Na+/K+-ATPase ("sodium pump") enzyme.	Tetradecanoylphorbol Acetate	65-90	chromosome 20 open reading frame 181	Homo sapiens	34-37
2565821-4	1989	Such reduced translocation of DG kinase by TPA is also observed in src-transformed cells, but not in myc-transformed cells.	Tetradecanoylphorbol Acetate	43-46	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	67-70
9392454-8	1997	In vivo co-exposure with phorbol-myristate-acetate (PMA) and TCDD also inhibited CYP1A1 induction.	Tetradecanoylphorbol Acetate	25-50	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	81-87
2714447-4	1989	Intracellular redistribution of PK-C caused by phorbol 12-myristate 13-acetate (PMA) was concentration-dependent and was due to translocation of isozyme III, because type II was insensitive to 5 x 10(-8) M PMA.	Tetradecanoylphorbol Acetate	47-78	protein kinase C, gamma	Rattus norvegicus	32-36
2714447-4	1989	Intracellular redistribution of PK-C caused by phorbol 12-myristate 13-acetate (PMA) was concentration-dependent and was due to translocation of isozyme III, because type II was insensitive to 5 x 10(-8) M PMA.	Tetradecanoylphorbol Acetate	80-83	protein kinase C, gamma	Rattus norvegicus	32-36
2564857-9	1989	In contrast, PMA-induced phosphorylation of TCR CD3 chains was significantly greater in Ta1+ cells as compared to Ta1- T cells.	Tetradecanoylphorbol Acetate	13-16	trace amine associated receptor 1	Homo sapiens	88-91
2564857-9	1989	In contrast, PMA-induced phosphorylation of TCR CD3 chains was significantly greater in Ta1+ cells as compared to Ta1- T cells.	Tetradecanoylphorbol Acetate	13-16	trace amine associated receptor 1	Homo sapiens	114-117
2948635-5	1987	Nuclear run-on assays showed that E1 transcription, as well as transcription of c-fos, c-myc, and beta-actin was stimulated in 293 cells within 30 min of TPA exposure and returned to basal levels by 60 min.	Tetradecanoylphorbol Acetate	154-157	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-85
9392454-8	1997	In vivo co-exposure with phorbol-myristate-acetate (PMA) and TCDD also inhibited CYP1A1 induction.	Tetradecanoylphorbol Acetate	52-55	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	81-87
9395471-2	1997	In the present studies we have examined the potential role of the mitogen-activated protein (MAP) kinase in the increased serine phosphorylation of IRS-1 observed in human embryonic kidney cells treated with an activator of protein kinase C, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	242-273	insulin receptor substrate 1	Homo sapiens	148-153
3098411-2	1987	At 5 h after their application to the skin, the complete tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the stage 2 promoter mezerein were the most potent in inhibiting GSH peroxidase activity and inducing ODC activity.	Tetradecanoylphorbol Acetate	72-108	ornithine decarboxylase, structural 1	Mus musculus	221-224
3098411-2	1987	At 5 h after their application to the skin, the complete tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the stage 2 promoter mezerein were the most potent in inhibiting GSH peroxidase activity and inducing ODC activity.	Tetradecanoylphorbol Acetate	110-113	ornithine decarboxylase, structural 1	Mus musculus	221-224
2496686-7	1989	However, when the freshly isolated regenerating T cells were cultured in the presence of Con A or PMA + ionophore A 23187, IL-2R was readily induced.	Tetradecanoylphorbol Acetate	98-101	interleukin 2 receptor, alpha chain	Mus musculus	123-128
9395471-4	1997	Second, an inhibitor of MAP kinase activation, PD98059, blocked the phorbol 12-myristate 13-acetate-induced inhibition of the insulin-stimulated increase in IRS-1 associated phosphatidylinositol 3-kinase.	Tetradecanoylphorbol Acetate	68-99	insulin receptor substrate 1	Homo sapiens	157-162
9371692-4	1997	S1P alone was a weak inducer of DNA synthesis, but its effects were enhanced by phosphocholine (PCho), insulin, ATP or PMA.	Tetradecanoylphorbol Acetate	119-122	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
2702729-3	1989	In DXME-protected skin, the hyperplastic stage was delayed; unexpectedly, before that stage, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced strongly ODC activity in the epidermal cell layer.	Tetradecanoylphorbol Acetate	93-130	ornithine decarboxylase, structural 1	Mus musculus	154-157
2702729-3	1989	In DXME-protected skin, the hyperplastic stage was delayed; unexpectedly, before that stage, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced strongly ODC activity in the epidermal cell layer.	Tetradecanoylphorbol Acetate	132-135	ornithine decarboxylase, structural 1	Mus musculus	154-157
2702729-4	1989	Provided that the proliferation process was induced, epidermal cells were increasingly sensitive toward TPA action; they may have been less dependent on inflammatory factors which may modulate the induction of ODC.	Tetradecanoylphorbol Acetate	104-107	ornithine decarboxylase, structural 1	Mus musculus	210-213
3791232-2	1987	However, we found that TPA could also partially protect human KB cells over a short time (72 h) from the cytotoxicity of several antitumor agents, including 4"-demethylepipodophyllotoxin 9-(4,6-O-ethylidene)-beta-D-glucopyranoside (VP-16), vincristine, mitoxantrone, and methotrexate, but not 1-beta-D-arabinofuranosylcytosine or 5-fluorouracil.	Tetradecanoylphorbol Acetate	23-26	host cell factor C1	Homo sapiens	232-237
3791232-8	1987	Verapamil, a calcium-channel blocker which has been found to circumvent resistance of multiple drug-resistant cells, also circumvented the protective effect of TPA when used with VP-16.	Tetradecanoylphorbol Acetate	160-163	host cell factor C1	Homo sapiens	179-184
3791232-9	1987	The presence of TPA during a 24-h exposure to radiolabeled VP-16 reduced the cellular drug content by about 30%, whereas verapamil enhanced drug content by at least 50% in TPA-treated and untreated cultures.	Tetradecanoylphorbol Acetate	16-19	host cell factor C1	Homo sapiens	59-64
9369943-0	1997	PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase 20	Homo sapiens	30-33
2830821-7	1987	The protein kinase C agonist, TPA, stimulates phosphorylation of the c-fos, but not the v-fos protein.	Tetradecanoylphorbol Acetate	30-33	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-74
2537172-3	1989	Incubation of ROS cells with PTH or phorbol 12-myristate 13-acetate (PMA) for 1-30 min caused a rapid and transient decrease in PKC activity in the cytosol, which was associated with a transient increase in PKC activity in the membrane fraction.	Tetradecanoylphorbol Acetate	36-67	protein kinase C, gamma	Rattus norvegicus	128-131
2537172-3	1989	Incubation of ROS cells with PTH or phorbol 12-myristate 13-acetate (PMA) for 1-30 min caused a rapid and transient decrease in PKC activity in the cytosol, which was associated with a transient increase in PKC activity in the membrane fraction.	Tetradecanoylphorbol Acetate	36-67	protein kinase C, gamma	Rattus norvegicus	207-210
2830821-7	1987	The protein kinase C agonist, TPA, stimulates phosphorylation of the c-fos, but not the v-fos protein.	Tetradecanoylphorbol Acetate	30-33	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-74
2537172-3	1989	Incubation of ROS cells with PTH or phorbol 12-myristate 13-acetate (PMA) for 1-30 min caused a rapid and transient decrease in PKC activity in the cytosol, which was associated with a transient increase in PKC activity in the membrane fraction.	Tetradecanoylphorbol Acetate	69-72	protein kinase C, gamma	Rattus norvegicus	128-131
9369943-2	1997	The protein kinase C inhibitor Ro 31-8220 specifically blocks PMA-induced differentiation, activation of the p42/44ERK- and p38RK-MAP kinase cascades and Hsp27-phosphorylation in HL-60 cells.	Tetradecanoylphorbol Acetate	62-65	heat shock protein family B (small) member 1	Homo sapiens	154-159
2537172-3	1989	Incubation of ROS cells with PTH or phorbol 12-myristate 13-acetate (PMA) for 1-30 min caused a rapid and transient decrease in PKC activity in the cytosol, which was associated with a transient increase in PKC activity in the membrane fraction.	Tetradecanoylphorbol Acetate	69-72	protein kinase C, gamma	Rattus norvegicus	207-210
9369949-6	1997	The increased F-actin content induced by PKC activators also was observed in suspension cells treated with TPA, and the kinetics of F-actin were similar to that for PKC activation.	Tetradecanoylphorbol Acetate	107-110	protein kinase C epsilon	Homo sapiens	41-44
2537172-6	1989	The effects of PTH and PMA on PKC were dose dependent, with ED50 values of 0.3 nM PTH and 4 nM PMA.	Tetradecanoylphorbol Acetate	23-26	protein kinase C, gamma	Rattus norvegicus	30-33
2537172-6	1989	The effects of PTH and PMA on PKC were dose dependent, with ED50 values of 0.3 nM PTH and 4 nM PMA.	Tetradecanoylphorbol Acetate	95-98	protein kinase C, gamma	Rattus norvegicus	30-33
2537172-7	1989	Chronic treatment of ROS cells for 3 days with PMA caused depletion of total PKC activity in cytosolic and membrane fractions to less than 10% of that in control cells.	Tetradecanoylphorbol Acetate	47-50	protein kinase C, gamma	Rattus norvegicus	77-80
3331712-1	1987	The combined effects of phorbol 12-myristate 13-acetate (PMA) and insulin on the suppression of mRNA coding for PEPCK (mRNAPEPCK) synthesis were additive.	Tetradecanoylphorbol Acetate	24-55	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	112-117
3331712-1	1987	The combined effects of phorbol 12-myristate 13-acetate (PMA) and insulin on the suppression of mRNA coding for PEPCK (mRNAPEPCK) synthesis were additive.	Tetradecanoylphorbol Acetate	57-60	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	112-117
9369949-7	1997	In addition, PKC epsilon, which is the PKC isoform most involved in regulating HeLa cell spreading in response to AA production, is more rapidly translocated to the membrane in response to TPA treatment than is the increase in F-actin.	Tetradecanoylphorbol Acetate	189-192	protein kinase C epsilon	Homo sapiens	13-24
2783943-0	1989	Requirements for modulation of the CD4 molecule in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	63-88	CD4 antigen	Mus musculus	35-38
9369949-7	1997	In addition, PKC epsilon, which is the PKC isoform most involved in regulating HeLa cell spreading in response to AA production, is more rapidly translocated to the membrane in response to TPA treatment than is the increase in F-actin.	Tetradecanoylphorbol Acetate	189-192	protein kinase C epsilon	Homo sapiens	13-16
9863191-5	1997	The results showed that the TF activities in A23187, PMA and A23187 + PMA groups were remarkably higher (P &lt; 0.01) than that in control.	Tetradecanoylphorbol Acetate	53-56	coagulation factor III, tissue factor	Homo sapiens	28-30
2498646-0	1989	An AP1-binding site in the c-fos gene can mediate induction by epidermal growth factor and 12-O-tetradecanoyl phorbol-13-acetate.	Tetradecanoylphorbol Acetate	91-128	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	3-6
2498646-0	1989	An AP1-binding site in the c-fos gene can mediate induction by epidermal growth factor and 12-O-tetradecanoyl phorbol-13-acetate.	Tetradecanoylphorbol Acetate	91-128	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-32
2498646-1	1989	We have demonstrated that two sequence elements in the c-fos promoter can mediate the response of the gene to epidermal growth factor and the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	157-194	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-60
3325885-7	1987	The c-fos mRNA expression increased in TPA-treated SH-SY5Y cells and remained high during extended exposure to the drug.	Tetradecanoylphorbol Acetate	39-42	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-9
3325885-9	1987	Thus, the TPA-induced neuronal differentiation of SH-SY5Y cells was compatible with high c-fos and a substantial N-myc mRNA expression.	Tetradecanoylphorbol Acetate	10-13	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-94
9863191-6	1997	Among the three treated groups, the TF activities in both A23187 group and A23187 + PMA group were lower than that in the PMA group (P &lt; 0.05), but the difference between the former two groups was statically insignificant (P &gt; 0.05).	Tetradecanoylphorbol Acetate	84-87	coagulation factor III, tissue factor	Homo sapiens	36-38
3790579-5	1986	One new polypeptide (p 62, Mr 58,000) was found in the medium of 12-O-tetradecanoylphorbol 13-acetate-treated cells.	Tetradecanoylphorbol Acetate	65-101	nucleoporin 62	Mus musculus	21-25
2498646-1	1989	We have demonstrated that two sequence elements in the c-fos promoter can mediate the response of the gene to epidermal growth factor and the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	196-199	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-60
9863191-6	1997	Among the three treated groups, the TF activities in both A23187 group and A23187 + PMA group were lower than that in the PMA group (P &lt; 0.05), but the difference between the former two groups was statically insignificant (P &gt; 0.05).	Tetradecanoylphorbol Acetate	122-125	coagulation factor III, tissue factor	Homo sapiens	36-38
9361374-5	1997	The phorbol-12-myristate-13-acetate (PMA) was a potent enhancer of TF expression in U-937.	Tetradecanoylphorbol Acetate	4-35	coagulation factor III, tissue factor	Homo sapiens	67-69
2465035-3	1989	On whole bone marrow cells, rGM-CSF had a colony-stimulating activity comparable to that of known sources of CSFs, ie, the supernatant (SN) of TPA 30-1 or 5637 cell lines, used as control.	Tetradecanoylphorbol Acetate	143-146	colony stimulating factor 2	Rattus norvegicus	28-35
3779635-2	1986	A time course and the dose-response curves of ODC induction paralleled that of ODC mRNA induction by TPA in MEC.	Tetradecanoylphorbol Acetate	101-104	ornithine decarboxylase, structural 1	Mus musculus	46-49
3779635-2	1986	A time course and the dose-response curves of ODC induction paralleled that of ODC mRNA induction by TPA in MEC.	Tetradecanoylphorbol Acetate	101-104	ornithine decarboxylase, structural 1	Mus musculus	79-82
3779635-4	1986	The magnitude of ODC induction was proportional to the amount of ODC mRNA increased by TPA.	Tetradecanoylphorbol Acetate	87-90	ornithine decarboxylase, structural 1	Mus musculus	17-20
9361374-5	1997	The phorbol-12-myristate-13-acetate (PMA) was a potent enhancer of TF expression in U-937.	Tetradecanoylphorbol Acetate	37-40	coagulation factor III, tissue factor	Homo sapiens	67-69
3779635-4	1986	The magnitude of ODC induction was proportional to the amount of ODC mRNA increased by TPA.	Tetradecanoylphorbol Acetate	87-90	ornithine decarboxylase, structural 1	Mus musculus	65-68
2912589-0	1989	Inhibition of the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate in mouse skin by sphingosine sulfate.	Tetradecanoylphorbol Acetate	67-103	ornithine decarboxylase, structural 1	Mus musculus	31-54
2912589-1	1989	We investigated the effect of sphingosine sulfate on the induction of ODC (ornithine decarboxylase) activity by TPA (12-O-tetradecanoylphorbol-13-acetate) in mouse skin.	Tetradecanoylphorbol Acetate	112-115	ornithine decarboxylase, structural 1	Mus musculus	70-73
3779635-5	1986	TPA (2 X 10(-7) M) failed to induce ODC activity in MEC plated in Ca2+-deprived medium; TPA induction of ODC could be resumed upon Ca2+ restoration in the medium.	Tetradecanoylphorbol Acetate	88-91	ornithine decarboxylase, structural 1	Mus musculus	105-108
9326347-7	1997	Phorbol myristate acetate (PMA) stimulation of ECV304 cells resulted in an increase of TF mRNA levels, which was abrogated when gene transcription was impaired, suggesting a transcriptional regulation of the TF gene by PMA.	Tetradecanoylphorbol Acetate	0-25	coagulation factor III, tissue factor	Homo sapiens	87-89
3779635-10	1986	Furthermore, palmitoylcarnitine, an inhibitor of protein kinase C, inhibited epidermal ODC induction and the increased level of ODC mRNA by TPA.	Tetradecanoylphorbol Acetate	140-143	ornithine decarboxylase, structural 1	Mus musculus	128-131
3779635-12	1986	Taken together, we conclude that activation of protein kinase C may be an early event in ODC gene transcription and skin tumor promotion by TPA.	Tetradecanoylphorbol Acetate	140-143	ornithine decarboxylase, structural 1	Mus musculus	89-92
3098181-3	1986	TPA can be considered as an amphiphilic compound, with a hydrophilic domain spanning the C-3 to C-20 region of the molecule and a lipophilic domain consisting of the acyl substituents on C-12 and C-13.	Tetradecanoylphorbol Acetate	0-3	complement C3	Homo sapiens	89-92
2912589-1	1989	We investigated the effect of sphingosine sulfate on the induction of ODC (ornithine decarboxylase) activity by TPA (12-O-tetradecanoylphorbol-13-acetate) in mouse skin.	Tetradecanoylphorbol Acetate	112-115	ornithine decarboxylase, structural 1	Mus musculus	75-98
2912589-1	1989	We investigated the effect of sphingosine sulfate on the induction of ODC (ornithine decarboxylase) activity by TPA (12-O-tetradecanoylphorbol-13-acetate) in mouse skin.	Tetradecanoylphorbol Acetate	117-153	ornithine decarboxylase, structural 1	Mus musculus	70-73
2912589-1	1989	We investigated the effect of sphingosine sulfate on the induction of ODC (ornithine decarboxylase) activity by TPA (12-O-tetradecanoylphorbol-13-acetate) in mouse skin.	Tetradecanoylphorbol Acetate	117-153	ornithine decarboxylase, structural 1	Mus musculus	75-98
2912589-3	1989	Significant inhibition of TPA-induced ODC activity was observed at 4, 6 and 8 h after TPA treatment in separate studies.	Tetradecanoylphorbol Acetate	26-29	ornithine decarboxylase, structural 1	Mus musculus	38-41
2912589-3	1989	Significant inhibition of TPA-induced ODC activity was observed at 4, 6 and 8 h after TPA treatment in separate studies.	Tetradecanoylphorbol Acetate	86-89	ornithine decarboxylase, structural 1	Mus musculus	38-41
2912589-4	1989	The results indicate that sphingosine sulfate is an effective inhibitor of ODC induction by TPA in mouse skin.	Tetradecanoylphorbol Acetate	92-95	ornithine decarboxylase, structural 1	Mus musculus	75-78
3098181-3	1986	TPA can be considered as an amphiphilic compound, with a hydrophilic domain spanning the C-3 to C-20 region of the molecule and a lipophilic domain consisting of the acyl substituents on C-12 and C-13.	Tetradecanoylphorbol Acetate	0-3	homeobox C13	Homo sapiens	196-200
9326347-7	1997	Phorbol myristate acetate (PMA) stimulation of ECV304 cells resulted in an increase of TF mRNA levels, which was abrogated when gene transcription was impaired, suggesting a transcriptional regulation of the TF gene by PMA.	Tetradecanoylphorbol Acetate	0-25	coagulation factor III, tissue factor	Homo sapiens	208-210
2651898-4	1989	Induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) led to a greater than 200-fold increase in PDGF-2 transcript levels in these cells.	Tetradecanoylphorbol Acetate	13-49	platelet derived growth factor subunit B	Homo sapiens	99-105
9326347-7	1997	Phorbol myristate acetate (PMA) stimulation of ECV304 cells resulted in an increase of TF mRNA levels, which was abrogated when gene transcription was impaired, suggesting a transcriptional regulation of the TF gene by PMA.	Tetradecanoylphorbol Acetate	27-30	coagulation factor III, tissue factor	Homo sapiens	87-89
2651898-4	1989	Induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) led to a greater than 200-fold increase in PDGF-2 transcript levels in these cells.	Tetradecanoylphorbol Acetate	51-54	platelet derived growth factor subunit B	Homo sapiens	99-105
2651898-7	1989	We also functionally identified different regulatory sequence elements of the PDGF-2 promoter in TPA-induced K562 cells.	Tetradecanoylphorbol Acetate	97-100	platelet derived growth factor subunit B	Homo sapiens	78-84
9326347-7	1997	Phorbol myristate acetate (PMA) stimulation of ECV304 cells resulted in an increase of TF mRNA levels, which was abrogated when gene transcription was impaired, suggesting a transcriptional regulation of the TF gene by PMA.	Tetradecanoylphorbol Acetate	27-30	coagulation factor III, tissue factor	Homo sapiens	208-210
2431072-7	1986	These data suggest that the proteinaceous plasma-derived cofactor acts in a fashion similar to TPA and that this as yet unexplained mechanism of TPA action is important to the full expression of epibolin and to the early phase of epidermal cell spreading.	Tetradecanoylphorbol Acetate	145-148	vitronectin	Homo sapiens	195-203
9345355-1	1997	Previous studies from this laboratory have shown that epidermal growth factor (EGF) and the tumor promoter, phorbol myristate acetate (PMA), are mitogenic in the endometrial cancer cell line HEC-1-A.	Tetradecanoylphorbol Acetate	108-133	epidermal growth factor	Homo sapiens	54-77
2879753-1	1986	Incubation of cultured ovine pituitary cells with the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA) (0.1-100 nM), caused a dose-related stimulation of both growth hormone (ED50 approximately 4 nM) and prolactin (ED50 approximately 14 nM) secretion.	Tetradecanoylphorbol Acetate	85-121	somatotropin	Ovis aries	184-198
2879753-1	1986	Incubation of cultured ovine pituitary cells with the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA) (0.1-100 nM), caused a dose-related stimulation of both growth hormone (ED50 approximately 4 nM) and prolactin (ED50 approximately 14 nM) secretion.	Tetradecanoylphorbol Acetate	123-126	somatotropin	Ovis aries	184-198
2879753-2	1986	Stimulation by TPA (100 nM) produced a substantial 10-fold increase in growth hormone with a smaller, 2-fold rise in prolactin secretion over 30 min; significant effects on the release of both hormones occurred within 2 min.	Tetradecanoylphorbol Acetate	15-18	somatotropin	Ovis aries	71-85
2624560-4	1989	With dispersed rat submandibular acinar-intercalated duct complexes, endogenous protein phosphorylation and mucin secretion studies were performed to determine if 12-O-tetradecanoylphorbol 13-acetate (PMA), a specific activator of protein kinase C, could act as an effective secretagogue for mucin secretion and if specific protein phosphorylation could be assigned to protein kinase C activation.	Tetradecanoylphorbol Acetate	163-199	solute carrier family 13 member 2	Rattus norvegicus	292-297
2498558-3	1989	TPA-caused responses in mouse skin such as skin tumor promotion, epidermal ornithine decarboxylase (ODC) induction and skin inflammation were inhibited by various lipoxygenase inhibitors of the arachidonic acid cascade.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	75-98
2879753-6	1986	At high concentrations (0.1-1.0 microM) dopamine also partially attenuated (by 43%) the TPA-induced stimulation of growth hormone secretion.	Tetradecanoylphorbol Acetate	88-91	somatotropin	Ovis aries	115-129
2498558-3	1989	TPA-caused responses in mouse skin such as skin tumor promotion, epidermal ornithine decarboxylase (ODC) induction and skin inflammation were inhibited by various lipoxygenase inhibitors of the arachidonic acid cascade.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	100-103
2879753-7	1986	Somatostatin (0.01-1.0 microM) completely inhibited the substantial (approximately 9-fold) TPA-induced stimulation of growth hormone secretion (inhibitory ED50 approximately 47 nM), and also suppressed TPA-stimulated prolactin secretion to the control level.	Tetradecanoylphorbol Acetate	91-94	somatotropin	Ovis aries	118-132
9378547-7	1997	c-myc can also form transcriptionally active heterodimeric complexes with the nuclear phosphoproteins p20/p22 max: thus, TPA treatment resulted in down-regulation of the p20 form of max in TUR cells.	Tetradecanoylphorbol Acetate	121-124	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
3093072-6	1986	Both the observed morphological changes and the expression of p21 were reversible in P+ cells when TPA exposure was terminated soon after foci had developed.	Tetradecanoylphorbol Acetate	99-102	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	62-65
3094975-0	1986	Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects.	Tetradecanoylphorbol Acetate	14-50	ornithine decarboxylase, structural 1	Mus musculus	70-93
3094975-4	1986	Induction of epidermal ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate (TPA; 10 nmol/mouse) was potently inhibited by these agents in a dose-dependent manner (1-30 mumol/mouse).	Tetradecanoylphorbol Acetate	50-86	ornithine decarboxylase, structural 1	Mus musculus	23-46
2915901-0	1989	Nucleotide sequence of a cDNA encoding TIS11, a message induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	105-134	zinc finger protein 36	Mus musculus	39-44
2915901-1	1989	We report here the nucleic acid sequence and deduced amino acid sequence of a cDNA for TIS11, a gene induced in 3T3 cells by tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	125-154	zinc finger protein 36	Mus musculus	87-92
9378547-7	1997	c-myc can also form transcriptionally active heterodimeric complexes with the nuclear phosphoproteins p20/p22 max: thus, TPA treatment resulted in down-regulation of the p20 form of max in TUR cells.	Tetradecanoylphorbol Acetate	121-124	calcineurin like EF-hand protein 1	Homo sapiens	106-109
3094975-4	1986	Induction of epidermal ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate (TPA; 10 nmol/mouse) was potently inhibited by these agents in a dose-dependent manner (1-30 mumol/mouse).	Tetradecanoylphorbol Acetate	88-91	ornithine decarboxylase, structural 1	Mus musculus	23-46
9316419-9	1997	Ecto-apyrase activity was modestly increased with differentiation of myeloid progenitors with either phorbol 12-myristate 13-acetate (PMA) or dibutyryl adenosine 3",5"-cyclic monophosphate (DBcAMP).	Tetradecanoylphorbol Acetate	101-132	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	0-12
3769135-5	1986	trans-Retinoic acid, a potent inhibitor of tumor promotion, markedly inhibited the epidermal induction of ornithine decarboxylase activity that resulted from the topical administration of sn-1,2-didecanoylglycerol or TPA.	Tetradecanoylphorbol Acetate	217-220	ornithine decarboxylase, structural 1	Mus musculus	106-129
2518685-5	1989	Mutations of the basic amino acids in fos protein prevent binding to TPA (phorbol ester)-responsive element (TRE) in the presence of wild-type jun protein.	Tetradecanoylphorbol Acetate	69-72	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-41
3265048-9	1988	The role of protein kinase C translocation and degradation in the PMA-induced responses in EL4 cells is unknown.	Tetradecanoylphorbol Acetate	66-69	epilepsy 4	Mus musculus	91-94
9316419-9	1997	Ecto-apyrase activity was modestly increased with differentiation of myeloid progenitors with either phorbol 12-myristate 13-acetate (PMA) or dibutyryl adenosine 3",5"-cyclic monophosphate (DBcAMP).	Tetradecanoylphorbol Acetate	134-137	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	0-12
9328180-1	1997	Phorbol ester-sensitive EL4 murine thymoma cells respond to phorbol 12-myristate 13-acetate with activation of ERK mitogen-activated protein kinases, synthesis of interleukin-2, and death, whereas phorbol ester-resistant variants of this cell line do not exhibit these responses.	Tetradecanoylphorbol Acetate	60-91	interleukin 2	Mus musculus	163-176
2848520-1	1988	In quiescent cultures of rabbit aortic smooth muscle cells, whole blood serum-induced DNA synthesis was inhibited markedly by protein kinase C-activating 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and phorbol-12, 13-dibutyrate (PDBu), cyclic AMP-derivatives, such as dibutyryl cyclic AMP (Bt2cAMP) and 8-bromo-cyclic AMP, and interferon alpha/beta.	Tetradecanoylphorbol Acetate	193-196	IFNA	Oryctolagus cuniculus	327-348
2848520-5	1988	TPA and Bt2cAMP inhibited the serum-induced DNA synthesis when added within 12 h after the addition of the serum, while interferon alpha/beta was active only when added within 6 h. These results suggest that there are at least three independent signaling systems, protein kinase C- and cyclic AMP-mediated systems and an unidentified system for interferon alpha/beta, which are involved in the antiproliferative mechanisms in rabbit aortic smooth muscle cells.	Tetradecanoylphorbol Acetate	0-3	IFNA	Oryctolagus cuniculus	345-366
3768726-1	1986	Serum-free aggregating cell cultures of fetal rat telencephalon treated with the potent tumor promoter phorbol 12-myristate 13-acetate (PMA) showed a dose-dependent, persistent stimulation of the enzymes choline acetyltransferase (ChAT), glutamic acid decarboxylase and glutamine synthetase.	Tetradecanoylphorbol Acetate	103-134	choline O-acetyltransferase	Rattus norvegicus	204-229
3768726-1	1986	Serum-free aggregating cell cultures of fetal rat telencephalon treated with the potent tumor promoter phorbol 12-myristate 13-acetate (PMA) showed a dose-dependent, persistent stimulation of the enzymes choline acetyltransferase (ChAT), glutamic acid decarboxylase and glutamine synthetase.	Tetradecanoylphorbol Acetate	136-139	choline O-acetyltransferase	Rattus norvegicus	204-229
10322942-4	1997	On the other hand, the expression level of c-myc gene in HL-60 cells decreased apparently after the preincubation of TA.	Tetradecanoylphorbol Acetate	117-119	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	43-48
3095123-9	1986	We observed that mitogenic doses of anti-T3 also induce an accumulation of c-fos mRNA, whose induction also is synergized by TPA.	Tetradecanoylphorbol Acetate	125-128	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-80
3017930-4	1986	When neutrophils were stimulated with phorbol myristate acetate in the presence of the heme-substituted peroxidase, a rapid accumulation of compound III, a complex of the enzyme with O-2, was observed accompanying an increase in oxygen consumption.	Tetradecanoylphorbol Acetate	38-63	immunoglobulin kappa variable 1D-39	Homo sapiens	183-186
3189535-2	1988	To assess whether protein kinase C (PKC) is involved in the regulation of gap junctions between primary differentiated cells, we studied the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on PKC translocation and junctional conductance of rat pancreatic exocrine cells.	Tetradecanoylphorbol Acetate	190-193	protein kinase C, gamma	Rattus norvegicus	198-201
3189535-3	1988	Our results show that although TPA induced the translocation of PKC from a "cytosolic" to a "microsomal" fraction within minutes, it failed to block the junctional conductance of acinar cell pairs up to 30 min after application.	Tetradecanoylphorbol Acetate	31-34	protein kinase C, gamma	Rattus norvegicus	64-67
3189535-4	1988	By contrast, analogous experiments on a liver-derived cell line (WB cells) showed that TPA-induced PKC translocation was paralleled by a marked and irreversible inhibition of intercellular coupling.	Tetradecanoylphorbol Acetate	87-90	protein kinase C, gamma	Rattus norvegicus	99-102
9281349-6	1997	To test this hypothesis, we studied the effect of calphostin C, a specific inhibitor of PKC that interacts with the cysteine-rich motif, and PMA (phorbol 12-myristate 13-acetate), an activator of several PKC isoforms that bind to the same region, on endosome fusion.	Tetradecanoylphorbol Acetate	146-177	protein kinase C gamma	Homo sapiens	204-207
3139287-1	1988	The effects of topically applied curcumin, chlorogenic acid, caffeic acid, and ferulic acid on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced epidermal ornithine decarboxylase activity, epidermal DNA synthesis, and the promotion of skin tumors were evaluated in female CD-1 mice.	Tetradecanoylphorbol Acetate	133-136	ornithine decarboxylase, structural 1	Mus musculus	156-179
3139287-2	1988	Topical application of 0.5, 1, 3, or 10 mumol of curcumin inhibited by 31, 46, 84, or 98%, respectively, the induction of epidermal ornithine decarboxylase activity by 5 nmol of TPA.	Tetradecanoylphorbol Acetate	178-181	ornithine decarboxylase, structural 1	Mus musculus	132-155
3139287-3	1988	In an additional study, the topical application of 10 mumol of curcumin, chlorogenic acid, caffeic acid, or ferulic acid inhibited by 91, 25, 42, or 46%, respectively, the induction of ornithine decarboxylase activity by 5 nmol of TPA.	Tetradecanoylphorbol Acetate	231-234	ornithine decarboxylase, structural 1	Mus musculus	185-208
3489544-5	1986	45, 1131) discovered that cross-linking of Ly-6 antigens on the cell surface acts in concert with phorbol myristate acetate to trigger mitogenesis in T cells.	Tetradecanoylphorbol Acetate	98-123	lymphocyte antigen 6 complex	Mus musculus	43-47
9281349-10	1997	In contrast, a glutathione S-transferase fusion protein containing a cysteine-rich region of the regulatory domain of PKCgamma inhibited endosome fusion in a PMA-dependent manner.	Tetradecanoylphorbol Acetate	158-161	protein kinase C gamma	Homo sapiens	118-126
3141077-1	1988	Recent work from this laboratory has demonstrated the presence of a structurally and functionally different ornithine decarboxylase (ODC) in mouse epidermal tumors induced by a two-stage protocol involving initiation with 7,12-dimethylbenzanthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	276-312	ornithine decarboxylase, structural 1	Mus musculus	108-131
9270009-3	1997	Using cultured mouse epidermal 308 cells, the steady-state levels of both 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC mRNA and c-fos were decreased by treatment with deguelin.	Tetradecanoylphorbol Acetate	112-115	FBJ osteosarcoma oncogene	Mus musculus	138-143
3141077-1	1988	Recent work from this laboratory has demonstrated the presence of a structurally and functionally different ornithine decarboxylase (ODC) in mouse epidermal tumors induced by a two-stage protocol involving initiation with 7,12-dimethylbenzanthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	276-312	ornithine decarboxylase, structural 1	Mus musculus	133-136
3141077-1	1988	Recent work from this laboratory has demonstrated the presence of a structurally and functionally different ornithine decarboxylase (ODC) in mouse epidermal tumors induced by a two-stage protocol involving initiation with 7,12-dimethylbenzanthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	314-317	ornithine decarboxylase, structural 1	Mus musculus	108-131
3169138-1	1988	The induction of differentiation in SH-SY5Y human neuroblastoma cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is accompanied by a rapid and a transient expression of c-fos mRNA and a down-regulation of c-myc mRNA.	Tetradecanoylphorbol Acetate	75-111	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	174-179
3169138-1	1988	The induction of differentiation in SH-SY5Y human neuroblastoma cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is accompanied by a rapid and a transient expression of c-fos mRNA and a down-regulation of c-myc mRNA.	Tetradecanoylphorbol Acetate	113-116	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	174-179
3169138-2	1988	The TPA-induced expression of c-fos mRNA was inhibited by H-7, a specific inhibitor of protein kinase C (PK-C).	Tetradecanoylphorbol Acetate	4-7	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-35
3091685-3	1986	The expression of rat IL 2R on those hybrid cells could be up-regulated by IL 2 itself, ATL-derived factor, and TPA and CA++ ionophore.	Tetradecanoylphorbol Acetate	112-115	interleukin 2 receptor, alpha chain	Mus musculus	22-27
3525223-1	1986	We have studied the possible involvement of the activation of calcium-dependent phospholipid-activated protein kinase (PK-C) in the stimulatory action of LHRH on Leydig cells, using 4 beta-phorbol-12-myristate-13-acetate (PMA) and phospholipase C (PL-C).	Tetradecanoylphorbol Acetate	222-225	protein kinase C, gamma	Rattus norvegicus	119-123
9270030-8	1997	Supershift electrophoresis mobility shift assay revealed that Jun B and c-Jun were absent from the AP-1/DNA complex following TNF-alpha but present following TPA treatment.	Tetradecanoylphorbol Acetate	158-161	jun B proto-oncogene	Mus musculus	62-67
3056960-8	1988	Phorbol myristate acetate (PMA)-induced grranulocyte adhesion to HUVE was significantly inhibited by anti-Mo1a and anti-beta, but not by anti-LFA-1a or anti-p150.	Tetradecanoylphorbol Acetate	0-25	integrin subunit alpha M	Homo sapiens	106-110
3056960-8	1988	Phorbol myristate acetate (PMA)-induced grranulocyte adhesion to HUVE was significantly inhibited by anti-Mo1a and anti-beta, but not by anti-LFA-1a or anti-p150.	Tetradecanoylphorbol Acetate	27-30	integrin subunit alpha M	Homo sapiens	106-110
9266828-4	1997	When over-expressed by transient transfection, SMRT inhibits MMP-1 promoter activity induced by interleukin-1 (IL-1), phorbol phorbol myristate acetate (PMA) or v-Src.	Tetradecanoylphorbol Acetate	153-156	matrix metallopeptidase 1	Homo sapiens	61-66
3272188-4	1988	As is the case with NGF, phorbol myristate acetate depresses aFGF-induced cell division and increases the outgrowth of neurites.	Tetradecanoylphorbol Acetate	25-50	fibroblast growth factor 1	Rattus norvegicus	61-65
3086451-11	1986	ICAM-1 isolated from phorbol myristic acetate (PMA) stimulated U937 and from fibroblasts yields an identical major product of Mr = 60,000 after chemical deglycosylation.	Tetradecanoylphorbol Acetate	47-50	intercellular adhesion molecule 1	Homo sapiens	0-6
9211894-3	1997	It was found that TPA inhibited androgen-induced PSA gene expression by a mechanism that did not alter nuclear levels of AR protein.	Tetradecanoylphorbol Acetate	18-21	kallikrein related peptidase 3	Homo sapiens	49-52
2847172-3	1988	Pretreatment with phorbol 12-myristate 13-acetate (PMA) caused a marked acceleration and amplification of m1 and m3 receptor-mediated arachidonic acid release.	Tetradecanoylphorbol Acetate	18-49	cholinergic receptor muscarinic 1	Homo sapiens	106-158
3458547-2	1986	Under identical conditions 7,8-BF also partially suppressed ornithine decarboxylase (ODC) activity in both unstimulated and TPA stimulated cultures.	Tetradecanoylphorbol Acetate	124-127	ornithine decarboxylase, structural 1	Mus musculus	60-83
9223434-3	1997	rTIMP-2 also bound with high affinity (Kd 0.99 nM) to HT1080 human fibrosarcoma cells treated with 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	99-136	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	0-7
3458547-2	1986	Under identical conditions 7,8-BF also partially suppressed ornithine decarboxylase (ODC) activity in both unstimulated and TPA stimulated cultures.	Tetradecanoylphorbol Acetate	124-127	ornithine decarboxylase, structural 1	Mus musculus	85-88
3458547-3	1986	The finding that 7,8-BF inhibition of TPA-induced ODC can not be overcome by addition of exogenous PGE2 suggests that ODC induction by TPA involves a prostaglandin-independent component.	Tetradecanoylphorbol Acetate	38-41	ornithine decarboxylase, structural 1	Mus musculus	50-53
3458547-3	1986	The finding that 7,8-BF inhibition of TPA-induced ODC can not be overcome by addition of exogenous PGE2 suggests that ODC induction by TPA involves a prostaglandin-independent component.	Tetradecanoylphorbol Acetate	135-138	ornithine decarboxylase, structural 1	Mus musculus	118-121
2847172-3	1988	Pretreatment with phorbol 12-myristate 13-acetate (PMA) caused a marked acceleration and amplification of m1 and m3 receptor-mediated arachidonic acid release.	Tetradecanoylphorbol Acetate	51-54	cholinergic receptor muscarinic 1	Homo sapiens	106-158
2846062-3	1988	This activity was similar to that of plasma membranes isolated from phorbol myristate acetate (PMA)-stimulated cells which possessed cytochrome b.	Tetradecanoylphorbol Acetate	68-93	mitochondrially encoded cytochrome b	Homo sapiens	133-145
2846062-3	1988	This activity was similar to that of plasma membranes isolated from phorbol myristate acetate (PMA)-stimulated cells which possessed cytochrome b.	Tetradecanoylphorbol Acetate	95-98	mitochondrially encoded cytochrome b	Homo sapiens	133-145
9211348-12	1997	PLA2 activation by PTH, -8-bromo-cAMP and PMA was assessed as 3H-AA release from prelabeled suspensions of neonatal and adult proximal tubules.	Tetradecanoylphorbol Acetate	42-45	phospholipase A2	Oryctolagus cuniculus	0-4
3139757-3	1988	Elevated H2O2 release in response to PMA was observed in resident macrophages after a 48-h incubation with IFN-gamma, TNF-alpha, TNF-beta, or CSF-GM.	Tetradecanoylphorbol Acetate	37-40	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	142-148
3139753-1	1988	We have previously shown that Lyt-2- L3T4- T cells from the lymph nodes of MRL/lpr/lpr mice could respond to 12-O-tetradecanoylphorbol-2-acetate (TPA) and A23187 by proliferation, IL-2 secretion, and IL-2R (IL-2R) expression.	Tetradecanoylphorbol Acetate	146-149	interleukin 2 receptor, alpha chain	Mus musculus	207-212
3139753-5	1988	TPA and A23187 synergistically induced both IL-2R and c-myc mRNA expression by the lpr Lyt-2- L3T4- T cells, as well as by normal T cells.	Tetradecanoylphorbol Acetate	0-3	interleukin 2 receptor, alpha chain	Mus musculus	44-49
2870134-1	1986	Serum-free aggregating cell cultures of fetal rat telencephalon treated with the potent tumor promoter phorbol 12-myristate 13-acetate (PMA) showed a marked, rapid, and sustained increase in the activity of the astrocyte-specific enzyme glutamine synthetase (GS).	Tetradecanoylphorbol Acetate	103-134	glutamate-ammonia ligase	Rattus norvegicus	237-257
2870134-1	1986	Serum-free aggregating cell cultures of fetal rat telencephalon treated with the potent tumor promoter phorbol 12-myristate 13-acetate (PMA) showed a marked, rapid, and sustained increase in the activity of the astrocyte-specific enzyme glutamine synthetase (GS).	Tetradecanoylphorbol Acetate	136-139	glutamate-ammonia ligase	Rattus norvegicus	237-257
9211348-14	1997	Thus, PTH, 8-bromo-cAMP and PMA stimulated PLA2 in adult but not neonatal proximal tubules.	Tetradecanoylphorbol Acetate	28-31	phospholipase A2	Oryctolagus cuniculus	43-47
3457882-2	1986	It was found that U937 responds to C3b by releasing both eicosanoids only after a 48 h induction period in the presence of PMA.	Tetradecanoylphorbol Acetate	123-126	complement C3	Homo sapiens	35-38
9254882-0	1997	Effect of 12-O-tetradecanoylphorbol-13-acetate on inhibition of expression of keratin 1 mRNA in mouse keratinocytes mimicked by 12(S)-hydroxyeicosatetraenoic acid.	Tetradecanoylphorbol Acetate	10-46	keratin 1	Mus musculus	78-87
9178763-6	1997	Stimulation of MMP-1 promoter by 12-O-tetradecanoyl phorbol-13-acetate and okadaic acid was differentially augmented by ETS-1 and ERGB/Fli-1, and abrogated by PU.1.	Tetradecanoylphorbol Acetate	33-70	matrix metallopeptidase 1	Homo sapiens	15-20
3519221-3	1986	The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration.	Tetradecanoylphorbol Acetate	12-15	vimentin	Mus musculus	62-70
3519221-3	1986	The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration.	Tetradecanoylphorbol Acetate	12-15	vimentin	Mus musculus	143-151
3519221-3	1986	The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration.	Tetradecanoylphorbol Acetate	12-15	vimentin	Mus musculus	143-151
3519221-3	1986	The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration.	Tetradecanoylphorbol Acetate	200-203	vimentin	Mus musculus	143-151
3519221-3	1986	The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration.	Tetradecanoylphorbol Acetate	200-203	vimentin	Mus musculus	143-151
3519221-3	1986	The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration.	Tetradecanoylphorbol Acetate	200-203	vimentin	Mus musculus	143-151
2970508-0	1988	Regulation of complement factor H synthesis in U-937 cells by phorbol myristate acetate, lipopolysaccharide, and IL-1.	Tetradecanoylphorbol Acetate	62-87	complement factor H	Homo sapiens	25-33
3413110-0	1988	Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7.	Tetradecanoylphorbol Acetate	76-107	amphiregulin	Homo sapiens	0-12
3165051-3	1988	We have previously shown that the PDGF-2 gene is expressed during 12-O-tetradecanoylphorbol-13-acetate (TPA) induced monocytic differentiation of human HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	66-102	platelet derived growth factor subunit B	Homo sapiens	34-40
3165051-3	1988	We have previously shown that the PDGF-2 gene is expressed during 12-O-tetradecanoylphorbol-13-acetate (TPA) induced monocytic differentiation of human HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	104-107	platelet derived growth factor subunit B	Homo sapiens	34-40
3165051-6	1988	In contrast, both PDGF-1 and PDGF-2 transcripts were detected in HL-60 cells and monocytes induced with TPA, while only PDGF-1 mRNA was found in TPA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	104-107	platelet derived growth factor subunit A	Homo sapiens	18-24
3165051-6	1988	In contrast, both PDGF-1 and PDGF-2 transcripts were detected in HL-60 cells and monocytes induced with TPA, while only PDGF-1 mRNA was found in TPA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	104-107	platelet derived growth factor subunit B	Homo sapiens	29-35
9178763-6	1997	Stimulation of MMP-1 promoter by 12-O-tetradecanoyl phorbol-13-acetate and okadaic acid was differentially augmented by ETS-1 and ERGB/Fli-1, and abrogated by PU.1.	Tetradecanoylphorbol Acetate	33-70	ETS proto-oncogene 1, transcription factor	Homo sapiens	120-125
3165051-6	1988	In contrast, both PDGF-1 and PDGF-2 transcripts were detected in HL-60 cells and monocytes induced with TPA, while only PDGF-1 mRNA was found in TPA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	145-148	platelet derived growth factor subunit A	Homo sapiens	120-126
3519221-3	1986	The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration.	Tetradecanoylphorbol Acetate	200-203	vimentin	Mus musculus	143-151
9178763-6	1997	Stimulation of MMP-1 promoter by 12-O-tetradecanoyl phorbol-13-acetate and okadaic acid was differentially augmented by ETS-1 and ERGB/Fli-1, and abrogated by PU.1.	Tetradecanoylphorbol Acetate	33-70	Spi-1 proto-oncogene	Homo sapiens	159-163
3519221-3	1986	The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration.	Tetradecanoylphorbol Acetate	200-203	vimentin	Mus musculus	143-151
3519221-3	1986	The minimum TPA concentration sufficient for the induction of vimentin synthesis was found to be 3 X 10(-9) M; substantially larger amounts of vimentin could be detected after treatment of cells with TPA at a concentration of 3 X 10(-8) M. At each effective TPA concentration tested, the maximum level of vimentin was reached after 18 to 24 h; it was dependent on the TPA concentration.	Tetradecanoylphorbol Acetate	200-203	vimentin	Mus musculus	143-151
9178763-8	1997	As compared to control cell lines, PU.1-positive stable cells exhibited clearly weaker binding of c-Jun and JunD containing AP-1 complexes to MMP-1 promoter AP-1 element, as well as marked reduction in basal level and induction of c-jun mRNA by 12-O-tetradecanoyl phorbol-13-acetate and okadaic acid, suggesting a novel mechanism for PU.1-mediated inhibition of AP-1 dependent gene expression.	Tetradecanoylphorbol Acetate	245-282	Spi-1 proto-oncogene	Homo sapiens	35-39
3519221-6	1986	The fact that only poly(A) +RNA from TPA-treated MPC-11 cells was able to direct vimentin synthesis in vitro suggests that in MPC-11 cells vimentin production is regulated at the transcriptional level.	Tetradecanoylphorbol Acetate	37-40	vimentin	Mus musculus	81-89
2840644-3	1988	Mouse GM-CSF gene was also activated by phytohaemagglutinin A (PHA)/phorbol myristate acetate (PMA) or PMA/calcium ionophore A23187 stimulation.	Tetradecanoylphorbol Acetate	68-93	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	6-12
3519221-6	1986	The fact that only poly(A) +RNA from TPA-treated MPC-11 cells was able to direct vimentin synthesis in vitro suggests that in MPC-11 cells vimentin production is regulated at the transcriptional level.	Tetradecanoylphorbol Acetate	37-40	vimentin	Mus musculus	139-147
9177393-5	1997	The c-jun and c-fos mRNA stimulation elicited by TPA was reduced by the PKC inhibitors, chelerythrine and staurosporine, and could not be mimicked by 4alpha-phorbol 12,13-didecanoate (a phorbol ester that fails to activate PKC), whereas the stimulation induced by EGF was diminished by the PTK inhibitor, genistein.	Tetradecanoylphorbol Acetate	49-52	epidermal growth factor	Homo sapiens	264-267
2840644-3	1988	Mouse GM-CSF gene was also activated by phytohaemagglutinin A (PHA)/phorbol myristate acetate (PMA) or PMA/calcium ionophore A23187 stimulation.	Tetradecanoylphorbol Acetate	95-98	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	6-12
2840644-3	1988	Mouse GM-CSF gene was also activated by phytohaemagglutinin A (PHA)/phorbol myristate acetate (PMA) or PMA/calcium ionophore A23187 stimulation.	Tetradecanoylphorbol Acetate	103-106	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	6-12
9177393-5	1997	The c-jun and c-fos mRNA stimulation elicited by TPA was reduced by the PKC inhibitors, chelerythrine and staurosporine, and could not be mimicked by 4alpha-phorbol 12,13-didecanoate (a phorbol ester that fails to activate PKC), whereas the stimulation induced by EGF was diminished by the PTK inhibitor, genistein.	Tetradecanoylphorbol Acetate	49-52	protein tyrosine kinase 2 beta	Homo sapiens	290-293
3293563-4	1988	Adenosine deaminase-stimulated lipolysis was enhanced by about 50% by PMA (100 ng/ml).	Tetradecanoylphorbol Acetate	70-73	adenosine deaminase	Rattus norvegicus	0-19
9153259-2	1997	In this study, L-selectin was found to be phosphorylated in lymphoblastoid cell lines, and phosphorylation was enhanced by phorbol ester (phorbol 12-myristate 13-acetate (PMA)) treatment.	Tetradecanoylphorbol Acetate	138-169	selectin L	Homo sapiens	15-25
3133109-4	1988	Treatment with TPA in vivo resulted in about 2-fold increases in the phosphorylations of epidermal proteins with molecular weights of 34,000 and 40,000 and isoelectric points of 4.7-5.1 and 5.2-6.2 (p34 and p40, respectively).	Tetradecanoylphorbol Acetate	15-18	interleukin 12b	Mus musculus	207-210
3133109-6	1988	Inhibitors of PKC, such as chlorpromazine, quercetin, and staurosporine inhibited these increases in phosphorylations of p34 and p40 on TPA treatment.	Tetradecanoylphorbol Acetate	136-139	interleukin 12b	Mus musculus	129-132
3948318-0	1986	The skin tumor-promoter 12-O-tetradecanoylphorbol-13-acetate induces transcription of the c-fos proto-oncogene in human bladder epithelial cells.	Tetradecanoylphorbol Acetate	24-60	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-95
3948318-1	1986	The effect of a single treatment with the skin tumor-promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of the cellular proto-oncogenes, c-myc, c-rasHa, c-rasKi and c-fos was examined in the non-tumorigenic human bladder epithelial cell line HCV 29.	Tetradecanoylphorbol Acetate	62-98	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	184-189
9153259-2	1997	In this study, L-selectin was found to be phosphorylated in lymphoblastoid cell lines, and phosphorylation was enhanced by phorbol ester (phorbol 12-myristate 13-acetate (PMA)) treatment.	Tetradecanoylphorbol Acetate	171-174	selectin L	Homo sapiens	15-25
3948318-2	1986	TPA (1 microgram/ml) increased the transcription of the c-fos gene of HCV 29 at least 50-fold, and this stimulation was observed within minutes.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	56-61
2455575-9	1988	An ultrastructural immunoperoxidase study demonstrated platelet GPIb and GPIIb/IIIa in both plasma membranes and protein synthesis areas such as perinuclear cisternae and endoplasmic reticulum after TPA induction.	Tetradecanoylphorbol Acetate	199-202	integrin subunit alpha 2b	Homo sapiens	73-78
9153259-6	1997	PMA-induced phosphorylation was on serine residues within the cytoplasmic tail of L-selectin that have been well conserved during recent evolution.	Tetradecanoylphorbol Acetate	0-3	selectin L	Homo sapiens	82-92
9148952-8	1997	In Rat-1DeltaRaf-1:ER cells, we observed a strong synergy of MKP-1 expression when cells were stimulated with estradiol in the presence of ionomycin, phorbol 12-myristate 13-acetate, or okadaic acid under conditions where these agents did not synergize for ERK activation.	Tetradecanoylphorbol Acetate	150-181	dual specificity phosphatase 1	Rattus norvegicus	61-66
2453228-3	1988	By themselves, murine colony-stimulating factor-1 (CSF-1) and recombinant murine granulocyte-macrophage CSF (GM-CSF) were stimulators of DNA synthesis in quiescent or noncycling BMMs, whereas recombinant murine interleukin-3 (IL-3) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), were weak mitogens.	Tetradecanoylphorbol Acetate	255-292	colony stimulating factor 1 (macrophage)	Mus musculus	22-49
2453228-3	1988	By themselves, murine colony-stimulating factor-1 (CSF-1) and recombinant murine granulocyte-macrophage CSF (GM-CSF) were stimulators of DNA synthesis in quiescent or noncycling BMMs, whereas recombinant murine interleukin-3 (IL-3) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), were weak mitogens.	Tetradecanoylphorbol Acetate	255-292	colony stimulating factor 1 (macrophage)	Mus musculus	51-56
2453228-3	1988	By themselves, murine colony-stimulating factor-1 (CSF-1) and recombinant murine granulocyte-macrophage CSF (GM-CSF) were stimulators of DNA synthesis in quiescent or noncycling BMMs, whereas recombinant murine interleukin-3 (IL-3) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), were weak mitogens.	Tetradecanoylphorbol Acetate	255-292	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	81-107
3940182-0	1986	Tumor promoter-induced refractory state against ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate in mouse epidermis.	Tetradecanoylphorbol Acetate	85-121	ornithine decarboxylase, structural 1	Mus musculus	48-71
3940182-1	1986	More than one application of the potent tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA), to mouse skin at intervals of more than 48 h led to a larger induction of ornithine decarboxylase (EC 4.1.1.17; ODC) than did a single application.	Tetradecanoylphorbol Acetate	63-99	ornithine decarboxylase, structural 1	Mus musculus	181-204
3940182-1	1986	More than one application of the potent tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA), to mouse skin at intervals of more than 48 h led to a larger induction of ornithine decarboxylase (EC 4.1.1.17; ODC) than did a single application.	Tetradecanoylphorbol Acetate	63-99	ornithine decarboxylase, structural 1	Mus musculus	219-222
2453228-3	1988	By themselves, murine colony-stimulating factor-1 (CSF-1) and recombinant murine granulocyte-macrophage CSF (GM-CSF) were stimulators of DNA synthesis in quiescent or noncycling BMMs, whereas recombinant murine interleukin-3 (IL-3) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), were weak mitogens.	Tetradecanoylphorbol Acetate	255-292	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	109-115
9144502-3	1997	Following treatment of neutrophils with FMLP, 12-O-tetradecanoylphorbol-13-acetate, or opsonized zymosan, pleckstrin was rapidly phosphorylated, which resulted in a shift in its electrophoretic mobility.	Tetradecanoylphorbol Acetate	46-82	pleckstrin	Homo sapiens	106-116
2453228-3	1988	By themselves, murine colony-stimulating factor-1 (CSF-1) and recombinant murine granulocyte-macrophage CSF (GM-CSF) were stimulators of DNA synthesis in quiescent or noncycling BMMs, whereas recombinant murine interleukin-3 (IL-3) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), were weak mitogens.	Tetradecanoylphorbol Acetate	294-297	colony stimulating factor 1 (macrophage)	Mus musculus	22-49
2453228-3	1988	By themselves, murine colony-stimulating factor-1 (CSF-1) and recombinant murine granulocyte-macrophage CSF (GM-CSF) were stimulators of DNA synthesis in quiescent or noncycling BMMs, whereas recombinant murine interleukin-3 (IL-3) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), were weak mitogens.	Tetradecanoylphorbol Acetate	294-297	colony stimulating factor 1 (macrophage)	Mus musculus	51-56
2453228-3	1988	By themselves, murine colony-stimulating factor-1 (CSF-1) and recombinant murine granulocyte-macrophage CSF (GM-CSF) were stimulators of DNA synthesis in quiescent or noncycling BMMs, whereas recombinant murine interleukin-3 (IL-3) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), were weak mitogens.	Tetradecanoylphorbol Acetate	294-297	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	81-107
2453228-3	1988	By themselves, murine colony-stimulating factor-1 (CSF-1) and recombinant murine granulocyte-macrophage CSF (GM-CSF) were stimulators of DNA synthesis in quiescent or noncycling BMMs, whereas recombinant murine interleukin-3 (IL-3) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), were weak mitogens.	Tetradecanoylphorbol Acetate	294-297	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	109-115
2453228-6	1988	CSF-1, GM-CSF, and IL-3 could also synergize with TPA; CSF-1 cooperated with 1-oleoyl-2-acetylglycerol (OAG), both sets of results pointing to an interaction with protein kinase C. LPS completely abolished the CSF-1-mediated stimulation of DNA synthesis.	Tetradecanoylphorbol Acetate	50-53	colony stimulating factor 1 (macrophage)	Mus musculus	0-5
2453228-6	1988	CSF-1, GM-CSF, and IL-3 could also synergize with TPA; CSF-1 cooperated with 1-oleoyl-2-acetylglycerol (OAG), both sets of results pointing to an interaction with protein kinase C. LPS completely abolished the CSF-1-mediated stimulation of DNA synthesis.	Tetradecanoylphorbol Acetate	50-53	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	7-13
3940182-1	1986	More than one application of the potent tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA), to mouse skin at intervals of more than 48 h led to a larger induction of ornithine decarboxylase (EC 4.1.1.17; ODC) than did a single application.	Tetradecanoylphorbol Acetate	101-104	ornithine decarboxylase, structural 1	Mus musculus	181-204
3940182-1	1986	More than one application of the potent tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA), to mouse skin at intervals of more than 48 h led to a larger induction of ornithine decarboxylase (EC 4.1.1.17; ODC) than did a single application.	Tetradecanoylphorbol Acetate	101-104	ornithine decarboxylase, structural 1	Mus musculus	219-222
3940182-6	1986	On the other hand, pretreatment with TPA caused a refractory effect on ODC induction by mezerein but potentiated ODC induction by ethylphenylpropiolate.	Tetradecanoylphorbol Acetate	37-40	ornithine decarboxylase, structural 1	Mus musculus	71-74
3940182-6	1986	On the other hand, pretreatment with TPA caused a refractory effect on ODC induction by mezerein but potentiated ODC induction by ethylphenylpropiolate.	Tetradecanoylphorbol Acetate	37-40	ornithine decarboxylase, structural 1	Mus musculus	113-116
3940182-7	1986	The epidermal cells escaped from the refractory state by repeated application of TPA at intervals of 24 h as well as at intervals of twice a week; that is, there was a full induction of ODC activity following a second application within 24 h of a prior application.	Tetradecanoylphorbol Acetate	81-84	ornithine decarboxylase, structural 1	Mus musculus	186-189
3940182-9	1986	Mixing of a soluble extract from mouse epidermis in the refractory state with that from TPA-stimulated epidermis gave essentially additive ODC activity.	Tetradecanoylphorbol Acetate	88-91	ornithine decarboxylase, structural 1	Mus musculus	139-142
3940182-11	1986	These results suggest that the refractory effect on ODC induction by TPA does not result from feedback regulation of ODC.	Tetradecanoylphorbol Acetate	69-72	ornithine decarboxylase, structural 1	Mus musculus	52-55
3135916-0	1988	TPA (12-O-tetradecanoylphorbol-13-acetate) enhances the central hypoglycemic action of thyrotropin-releasing hormone in mice.	Tetradecanoylphorbol Acetate	0-3	thyrotropin releasing hormone	Mus musculus	87-116
3135916-0	1988	TPA (12-O-tetradecanoylphorbol-13-acetate) enhances the central hypoglycemic action of thyrotropin-releasing hormone in mice.	Tetradecanoylphorbol Acetate	5-41	thyrotropin releasing hormone	Mus musculus	87-116
9164840-16	1997	NPR-C measured as 125I-ANP binding was likewise reduced 36.4(+/-5.1)% by exposure to PMA.	Tetradecanoylphorbol Acetate	85-88	natriuretic peptide receptor 3	Homo sapiens	0-5
3135916-1	1988	This study examined the effect of the calcium- and phospholipid-dependent protein kinase C (PKC) activator, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on the plasma glucose responses to central thyrotropin-releasing hormone (TRH) injection in mice in order to evaluate the involvement of PKC in the mechanism of TRH action in the central nervous system (CNS).	Tetradecanoylphorbol Acetate	108-145	thyrotropin releasing hormone	Mus musculus	195-224
3135916-1	1988	This study examined the effect of the calcium- and phospholipid-dependent protein kinase C (PKC) activator, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on the plasma glucose responses to central thyrotropin-releasing hormone (TRH) injection in mice in order to evaluate the involvement of PKC in the mechanism of TRH action in the central nervous system (CNS).	Tetradecanoylphorbol Acetate	108-145	thyrotropin releasing hormone	Mus musculus	226-229
3762216-5	1986	Phosphorylation of various cell lysate proteins (p18, p21, p29, p34 and p45) were also stimulated by TPA.	Tetradecanoylphorbol Acetate	101-104	cyclin dependent kinase inhibitor 2C	Mus musculus	49-52
3762216-5	1986	Phosphorylation of various cell lysate proteins (p18, p21, p29, p34 and p45) were also stimulated by TPA.	Tetradecanoylphorbol Acetate	101-104	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	54-57
3133307-1	1988	Supernatants from phorbol myristate acetate (PMA)-stimulated EL4.IL2 cells (EL4.PMA), but not recombinant IL-2 (rIL-2), induced the production of cytotoxic T lymphocytes (CTL) in low density murine spleen cell cultures.	Tetradecanoylphorbol Acetate	18-43	epilepsy 4	Mus musculus	61-64
9139727-3	1997	After phorbol 12-myristate 13-acetate addition, the same serum-starved cells regained p67 mRNA, p67 protein, and protein synthesis activity.	Tetradecanoylphorbol Acetate	6-37	methionyl aminopeptidase 2	Rattus norvegicus	86-89
3133307-1	1988	Supernatants from phorbol myristate acetate (PMA)-stimulated EL4.IL2 cells (EL4.PMA), but not recombinant IL-2 (rIL-2), induced the production of cytotoxic T lymphocytes (CTL) in low density murine spleen cell cultures.	Tetradecanoylphorbol Acetate	18-43	epilepsy 4	Mus musculus	76-79
3133307-1	1988	Supernatants from phorbol myristate acetate (PMA)-stimulated EL4.IL2 cells (EL4.PMA), but not recombinant IL-2 (rIL-2), induced the production of cytotoxic T lymphocytes (CTL) in low density murine spleen cell cultures.	Tetradecanoylphorbol Acetate	45-48	epilepsy 4	Mus musculus	61-64
3133307-1	1988	Supernatants from phorbol myristate acetate (PMA)-stimulated EL4.IL2 cells (EL4.PMA), but not recombinant IL-2 (rIL-2), induced the production of cytotoxic T lymphocytes (CTL) in low density murine spleen cell cultures.	Tetradecanoylphorbol Acetate	45-48	epilepsy 4	Mus musculus	76-79
3411820-6	1988	A topical application of TPA to the skin caused epidermal ODC induction in all of these strains of mice.	Tetradecanoylphorbol Acetate	25-28	ornithine decarboxylase, structural 1	Mus musculus	58-61
3411820-7	1988	At any doses of TPA, TPA-induced epidermal ODC activity of C57BL/6 mice was always higher than those of SENCAR and CD-1 mice.	Tetradecanoylphorbol Acetate	16-19	ornithine decarboxylase, structural 1	Mus musculus	43-46
3411820-7	1988	At any doses of TPA, TPA-induced epidermal ODC activity of C57BL/6 mice was always higher than those of SENCAR and CD-1 mice.	Tetradecanoylphorbol Acetate	21-24	ornithine decarboxylase, structural 1	Mus musculus	43-46
3081875-2	1986	TPA stimulated the release of acinar cell mucin and ductal cell protease (arginine esterase) in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 13 member 2	Rattus norvegicus	42-47
3081875-5	1986	Mucin and enzyme secretion caused by TPA or OAG in the rat submandibular model was not inhibited by either of two putative antagonists, the antipsychotic drug, fluphenazine, and the antibiotic, polymyxin B.	Tetradecanoylphorbol Acetate	37-40	solute carrier family 13 member 2	Rattus norvegicus	0-5
3081875-7	1986	Although extracellular Ca2+ was not an absolute requirement for a secretory response, the results indicate a synergistic relationship between TPA and Ca2+ in stimulating the release of both mucin and arginine esterase.	Tetradecanoylphorbol Acetate	142-145	solute carrier family 13 member 2	Rattus norvegicus	190-195
3411820-8	1988	Maximal induction of epidermal ODC by TPA was also highest in C57BL/6 mice among these three strains of mice.	Tetradecanoylphorbol Acetate	38-41	ornithine decarboxylase, structural 1	Mus musculus	31-34
9139727-3	1997	After phorbol 12-myristate 13-acetate addition, the same serum-starved cells regained p67 mRNA, p67 protein, and protein synthesis activity.	Tetradecanoylphorbol Acetate	6-37	methionyl aminopeptidase 2	Rattus norvegicus	96-99
3411820-9	1988	These results indicate that the mechanism of the difference in susceptibility of C57BL/6, CD-1 and SENCAR mice to the tumor-promoting action TPA resides in a step distal to or other than the protein kinase C activation and ODC induction.	Tetradecanoylphorbol Acetate	141-144	ornithine decarboxylase, structural 1	Mus musculus	223-226
2835653-7	1988	Pretreatment of RBL-1 cells with staurosporine inhibited the PMA-induced activation of PKC in the membrane fraction.	Tetradecanoylphorbol Acetate	61-64	RB transcriptional corepressor like 1	Rattus norvegicus	16-21
3083437-0	1986	Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and tumor promotion by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) in mouse skin.	Tetradecanoylphorbol Acetate	14-50	ornithine decarboxylase, structural 1	Mus musculus	69-92
3083437-1	1986	N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibited epidermal ornithine decarboxylase (ODC) induction caused either by 12-O-tetradecanoylphorbol-13-acetate (TPA) or teleocidin in CD-1 mice.	Tetradecanoylphorbol Acetate	134-170	ornithine decarboxylase, structural 1	Mus musculus	77-100
3083437-1	1986	N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibited epidermal ornithine decarboxylase (ODC) induction caused either by 12-O-tetradecanoylphorbol-13-acetate (TPA) or teleocidin in CD-1 mice.	Tetradecanoylphorbol Acetate	134-170	ornithine decarboxylase, structural 1	Mus musculus	102-105
9157959-7	1997	Both aFGF and bFGF suppressed the phorbol myristate acetate-induced expression of TF in endothelial cells but not the serum-induced expression of TF in fibroblast cells.	Tetradecanoylphorbol Acetate	34-59	coagulation factor III, tissue factor	Homo sapiens	82-84
2835653-9	1988	These results show that PMA-induced heterologous desensitization is mediated by PKC and staurosporine prevented this process by directly inhibiting PKC in intact RBL-1 cells.	Tetradecanoylphorbol Acetate	24-27	RB transcriptional corepressor like 1	Rattus norvegicus	162-167
9187876-7	1997	However, over 24 h in the presence of the active phorbol ester, phorbol myristate acetate (PMA), significant release of GM-CSF was seen.	Tetradecanoylphorbol Acetate	64-89	colony stimulating factor 2	Homo sapiens	120-126
3129437-6	1988	The Gly-24 TR behaves identically to the wild-type TR when cells are treated with PMA.	Tetradecanoylphorbol Acetate	82-85	transferrin receptor protein 1	Cricetulus griseus	11-13
3129437-6	1988	The Gly-24 TR behaves identically to the wild-type TR when cells are treated with PMA.	Tetradecanoylphorbol Acetate	82-85	transferrin receptor protein 1	Cricetulus griseus	51-53
2838949-2	1988	PMA at 5 ng/ml + Concanavalin A at 5 micrograms/ml treatment of peripheral blood mononuclear cells gave a greater yield of IL 2 activity in the supernatants than Con A, PMA or sodium periodate treatments alone.	Tetradecanoylphorbol Acetate	0-3	interleukin 2	Bos taurus	123-127
3083437-1	1986	N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibited epidermal ornithine decarboxylase (ODC) induction caused either by 12-O-tetradecanoylphorbol-13-acetate (TPA) or teleocidin in CD-1 mice.	Tetradecanoylphorbol Acetate	172-175	ornithine decarboxylase, structural 1	Mus musculus	102-105
3083437-2	1986	Inhibitory effect of W-7 on TPA-caused ODC induction was also observed in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated skin and even after repetitive TPA treatment.	Tetradecanoylphorbol Acetate	28-31	ornithine decarboxylase, structural 1	Mus musculus	39-42
3083437-2	1986	Inhibitory effect of W-7 on TPA-caused ODC induction was also observed in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated skin and even after repetitive TPA treatment.	Tetradecanoylphorbol Acetate	153-156	ornithine decarboxylase, structural 1	Mus musculus	39-42
4066701-7	1985	Ghosts from TPA-treated cells showed a marked increase in the phosphorylation of five proteins (termed PK-C-1-5) of Mr 120,000, 110,000, 80,000, 78,000, and 49,000.	Tetradecanoylphorbol Acetate	12-15	protein kinase C zeta	Homo sapiens	103-111
4066701-12	1985	Incubation of 32P-prelabeled erythrocytes with TPA (EC50 = 40 nM) also resulted in a dose-dependent phosphorylation of PK-C-1-5.	Tetradecanoylphorbol Acetate	47-50	protein kinase C zeta	Homo sapiens	119-127
3257396-13	1988	Taken together these results and previous work on the induction of the protooncogene c-myc and c-fos suggest that this B-CLL clone represents GO cells that undergo differentiation without concomitant proliferation when exposed to TPA.	Tetradecanoylphorbol Acetate	230-233	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	95-100
9187876-7	1997	However, over 24 h in the presence of the active phorbol ester, phorbol myristate acetate (PMA), significant release of GM-CSF was seen.	Tetradecanoylphorbol Acetate	91-94	colony stimulating factor 2	Homo sapiens	120-126
9150275-6	1997	Treatment with the phorbol ester PMA or with EGF, strongly increased uPA production (P &lt; 0.001).	Tetradecanoylphorbol Acetate	33-36	plasminogen activator, urokinase	Mus musculus	69-72
4066760-0	1985	Phorbol esters and gene expression: the role of rapid changes in K+ transport in the induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate in BALB/c 3T3 cells and a mutant cell line defective in Na+K+Cl- cotransport.	Tetradecanoylphorbol Acetate	125-161	ornithine decarboxylase, structural 1	Mus musculus	98-121
3123083-2	1988	Formation of papillomas by applications of TPA to 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mouse skin was effectively inhibited by simultaneous topical applications of MGBB, MGBB also dose-dependently inhibited the ability of TPA to induce increases of ODC activity, ODC mRNA level and the accumulation of putrescine and spermidine in mouse skin.	Tetradecanoylphorbol Acetate	43-46	ornithine decarboxylase, structural 1	Mus musculus	260-263
9150279-4	1997	The pretreatment of PKC-alpha transfected cells with ANP significantly inhibited the TPA-, ANG II- and ET-1-stimulated PKC activity.	Tetradecanoylphorbol Acetate	85-88	natriuretic peptide type A	Mus musculus	53-56
3123083-2	1988	Formation of papillomas by applications of TPA to 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mouse skin was effectively inhibited by simultaneous topical applications of MGBB, MGBB also dose-dependently inhibited the ability of TPA to induce increases of ODC activity, ODC mRNA level and the accumulation of putrescine and spermidine in mouse skin.	Tetradecanoylphorbol Acetate	43-46	ornithine decarboxylase, structural 1	Mus musculus	274-277
4066760-8	1985	To establish a possible link between early changes in cation fluxes and activation of gene expression by TPA, the induction of the enzyme ornithine decarboxylase (ODC) was studied in detail.	Tetradecanoylphorbol Acetate	105-108	ornithine decarboxylase, structural 1	Mus musculus	138-161
4066760-8	1985	To establish a possible link between early changes in cation fluxes and activation of gene expression by TPA, the induction of the enzyme ornithine decarboxylase (ODC) was studied in detail.	Tetradecanoylphorbol Acetate	105-108	ornithine decarboxylase, structural 1	Mus musculus	163-166
9108029-7	1997	Phorbol 12-myristate 13 acetate efficiently translocated TRX into the HeLa cell nucleus where Ref-1 preexists.	Tetradecanoylphorbol Acetate	0-31	thioredoxin	Homo sapiens	57-60
3338115-0	1988	Palmitoylcarnitine reverses 12-O-tetradecanoylphorbol-13-acetate-induced refractory state for the TPA-caused ornithine decarboxylase induction in mouse epidermis.	Tetradecanoylphorbol Acetate	28-64	ornithine decarboxylase, structural 1	Mus musculus	109-132
9108029-8	1997	This process seems to be essential for AP-1 activation by redox modification because co-overexpression of TRX and Ref-1 in COS-7 cells potentiated AP-1 activity only after TRX was transported into the nucleus by phorbol 12-myristate 13 acetate treatment.	Tetradecanoylphorbol Acetate	212-243	thioredoxin	Homo sapiens	106-109
3338115-0	1988	Palmitoylcarnitine reverses 12-O-tetradecanoylphorbol-13-acetate-induced refractory state for the TPA-caused ornithine decarboxylase induction in mouse epidermis.	Tetradecanoylphorbol Acetate	98-101	ornithine decarboxylase, structural 1	Mus musculus	109-132
3931725-16	1985	Synthesis of CA I, as with other erythroid markers such as glycophorin A and hemoglobin, was almost abolished after 12-O-tetradecanoyl-phorbol-13 acetate treatment of HEL cells.	Tetradecanoylphorbol Acetate	116-153	carbonic anhydrase 1	Homo sapiens	13-17
3338115-1	1988	When a single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was performed 12 h before the second application, ornithine decarboxylase (ODC) induction by the second application of TPA was markedly suppressed (refractory state).	Tetradecanoylphorbol Acetate	37-73	ornithine decarboxylase, structural 1	Mus musculus	130-153
3338115-1	1988	When a single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was performed 12 h before the second application, ornithine decarboxylase (ODC) induction by the second application of TPA was markedly suppressed (refractory state).	Tetradecanoylphorbol Acetate	37-73	ornithine decarboxylase, structural 1	Mus musculus	155-158
3338115-1	1988	When a single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was performed 12 h before the second application, ornithine decarboxylase (ODC) induction by the second application of TPA was markedly suppressed (refractory state).	Tetradecanoylphorbol Acetate	75-78	ornithine decarboxylase, structural 1	Mus musculus	130-153
3338115-1	1988	When a single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was performed 12 h before the second application, ornithine decarboxylase (ODC) induction by the second application of TPA was markedly suppressed (refractory state).	Tetradecanoylphorbol Acetate	75-78	ornithine decarboxylase, structural 1	Mus musculus	155-158
9108029-8	1997	This process seems to be essential for AP-1 activation by redox modification because co-overexpression of TRX and Ref-1 in COS-7 cells potentiated AP-1 activity only after TRX was transported into the nucleus by phorbol 12-myristate 13 acetate treatment.	Tetradecanoylphorbol Acetate	212-243	thioredoxin	Homo sapiens	172-175
3338115-1	1988	When a single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was performed 12 h before the second application, ornithine decarboxylase (ODC) induction by the second application of TPA was markedly suppressed (refractory state).	Tetradecanoylphorbol Acetate	199-202	ornithine decarboxylase, structural 1	Mus musculus	130-153
3338115-1	1988	When a single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was performed 12 h before the second application, ornithine decarboxylase (ODC) induction by the second application of TPA was markedly suppressed (refractory state).	Tetradecanoylphorbol Acetate	199-202	ornithine decarboxylase, structural 1	Mus musculus	155-158
9092538-3	1997	We report here that phorbol 12-myristate 13-acetate stimulation of T cells also enhanced the interaction between Cbl and two 14-3-3 isoforms (tau and zeta).	Tetradecanoylphorbol Acetate	20-51	Cbl proto-oncogene	Homo sapiens	113-154
3338115-2	1988	However, at intervals of 96 h between the first and the second application, the ODC activity induced by the second application of TPA was higher (enhanced state) than the activity induced by the single application.	Tetradecanoylphorbol Acetate	130-133	ornithine decarboxylase, structural 1	Mus musculus	80-83
3338115-7	1988	Pretreatment of mice with TPA 12 h or 96 h before the second TPA application resulted in the reduction or the increase in the Vmax values of ODC both for ornithine and pyridoxal-5"-phosphate, respectively.	Tetradecanoylphorbol Acetate	26-29	ornithine decarboxylase, structural 1	Mus musculus	141-144
4075283-3	1985	The ability of ADR to deplete the intracellular level of GSH correlated with its ability to increase basal and TPA-induced ornithine decarboxylase (ODC, L-ornithine carboxylase, EC 4.1.1.17) activities.	Tetradecanoylphorbol Acetate	111-114	ornithine decarboxylase, structural 1	Mus musculus	123-146
4075283-3	1985	The ability of ADR to deplete the intracellular level of GSH correlated with its ability to increase basal and TPA-induced ornithine decarboxylase (ODC, L-ornithine carboxylase, EC 4.1.1.17) activities.	Tetradecanoylphorbol Acetate	111-114	ornithine decarboxylase, structural 1	Mus musculus	148-151
3338115-7	1988	Pretreatment of mice with TPA 12 h or 96 h before the second TPA application resulted in the reduction or the increase in the Vmax values of ODC both for ornithine and pyridoxal-5"-phosphate, respectively.	Tetradecanoylphorbol Acetate	61-64	ornithine decarboxylase, structural 1	Mus musculus	141-144
9195048-1	1997	The induction of JE/MCP-1 gene by TPA was transcriptionally suppressed by antioxidants such as pyrrolidine dithiocarbamate (PDTC) or trimethylthiourea (TMTU) in Balb 3T3 cells, whereas that of other early response genes, c-fos or egr-1, was not affected by these agents.	Tetradecanoylphorbol Acetate	34-37	FBJ osteosarcoma oncogene	Mus musculus	221-226
3338115-12	1988	The TPA-induced refractory state and the enhanced state for ODC induction appear to result from the changes in the protein kinase C activities caused by TPA.	Tetradecanoylphorbol Acetate	153-156	ornithine decarboxylase, structural 1	Mus musculus	60-63
3338115-13	1988	However, it is not known whether such changes in the protein kinase C activities are the major causes for the TPA-induced refractory and/or enhanced state for ODC induction and whether or not the restorative effect of palmitoylcarnitine is due to its modulating action on protein kinase C activity.	Tetradecanoylphorbol Acetate	110-113	ornithine decarboxylase, structural 1	Mus musculus	159-162
4075283-4	1985	In vivo, topical ADR treatments also enhanced TPA-induced ODC activity as well as the tumor-promoting ability of TPA in the two-stage system of mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	46-49	ornithine decarboxylase, structural 1	Mus musculus	58-61
3932370-1	1985	rac-1-O-Myristoyl-2-O-acetylglycerol, rac-1-O-palmitoyl-2-O-acetylglycerol, and rac-1-O-oleoyl-2-O-acetylglycerol acted like phorbol myristate acetate and mezerein in stimulating human neutrophil aggregation.	Tetradecanoylphorbol Acetate	125-150	Rac family small GTPase 1	Homo sapiens	0-5
9195048-1	1997	The induction of JE/MCP-1 gene by TPA was transcriptionally suppressed by antioxidants such as pyrrolidine dithiocarbamate (PDTC) or trimethylthiourea (TMTU) in Balb 3T3 cells, whereas that of other early response genes, c-fos or egr-1, was not affected by these agents.	Tetradecanoylphorbol Acetate	34-37	early growth response 1	Mus musculus	230-235
2840274-7	1988	A calcium ionophore, A23187 (10(-7) M), and 12-O-tetradecanoylphorbol-13-acetate (10(-8) M), a direct stimulator of protein kinase C, stimulated the release of DHEA-S, but not those of Ald, B and F. The results suggest that SW-13 retains functioning adenylate cyclase which, however, is not linked with steroidogenesis and that DHEA-S is produced probably by the mechanisms which involve protein kinase C system or calcium ion.	Tetradecanoylphorbol Acetate	44-80	sulfotransferase family 2A member 1	Homo sapiens	160-166
2840274-7	1988	A calcium ionophore, A23187 (10(-7) M), and 12-O-tetradecanoylphorbol-13-acetate (10(-8) M), a direct stimulator of protein kinase C, stimulated the release of DHEA-S, but not those of Ald, B and F. The results suggest that SW-13 retains functioning adenylate cyclase which, however, is not linked with steroidogenesis and that DHEA-S is produced probably by the mechanisms which involve protein kinase C system or calcium ion.	Tetradecanoylphorbol Acetate	44-80	sulfotransferase family 2A member 1	Homo sapiens	328-334
9156339-2	1997	Induction of morphogenesis by TPA is accompanied by increased activity of the collagenase gene transcription factors, ETS1 and API, and the elaboration of collagenase by the endothelial cells.	Tetradecanoylphorbol Acetate	30-33	ETS proto-oncogene 1, transcription factor	Homo sapiens	118-122
2997786-4	1985	cAMP, epidermal growth factor, the phorbol ester phorbol 12-myristate 13-acetate, and K+ depolarization also induce the fos gene.	Tetradecanoylphorbol Acetate	49-80	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	120-123
9156339-7	1997	Further studies showed that inhibition of TPA-induced endothelial cell morphogenesis by oxLDL is correlated with suppression of the protein kinase C (PKC) and ETS1/AP1 activities.	Tetradecanoylphorbol Acetate	42-45	ETS proto-oncogene 1, transcription factor	Homo sapiens	159-163
2968003-0	1988	Induction of the CD4-8+ suppressor phenotype in CD4+8+ human thymocytes by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	75-100	CD48 molecule	Homo sapiens	17-22
10495787-4	1997	Ribonuclease protection assay revealed the expression of ECE-1 and -2 in cultured GEN, and the expression was increased approximately 2.5- and approximately 1.8-fold, respectively, by treatment with 10(-7) M 12-O-tetradecanocyl-phorbol-13-acetate (TPA) for 4 hours.	Tetradecanoylphorbol Acetate	248-251	endothelin converting enzyme 1	Homo sapiens	57-69
3136087-2	1988	These highly purified cell populations were examined for their proliferative responses, interleukin 2 (IL2) production and expression of IL2 receptor (IL2R) in response to phorbol myristate acetate (PMA) and the calcium ionophore A23187 (A2) or PMA plus concanavalin A.	Tetradecanoylphorbol Acetate	172-197	interleukin 2 receptor, alpha chain	Mus musculus	137-149
3136087-2	1988	These highly purified cell populations were examined for their proliferative responses, interleukin 2 (IL2) production and expression of IL2 receptor (IL2R) in response to phorbol myristate acetate (PMA) and the calcium ionophore A23187 (A2) or PMA plus concanavalin A.	Tetradecanoylphorbol Acetate	172-197	interleukin 2 receptor, alpha chain	Mus musculus	151-155
3136087-2	1988	These highly purified cell populations were examined for their proliferative responses, interleukin 2 (IL2) production and expression of IL2 receptor (IL2R) in response to phorbol myristate acetate (PMA) and the calcium ionophore A23187 (A2) or PMA plus concanavalin A.	Tetradecanoylphorbol Acetate	199-202	interleukin 2 receptor, alpha chain	Mus musculus	137-149
2934802-2	1985	Using the immune adherence method, we demonstrated that the amount of covalently fixed (i.e., C3bA-bound) C3b is markedly increased upon cell stimulation by phorbol myristate acetate or aggregated IgG, even in the absence of C3.	Tetradecanoylphorbol Acetate	157-182	complement C3	Homo sapiens	94-97
3161611-5	1985	In contrast, TPA treatment resulted in the rapid disappearance of PL-Ca-PK and the induction of phospholipid- and Ca2+- (PL-Ca-) independent protein kinase activity.	Tetradecanoylphorbol Acetate	13-16	carbonic anhydrase 2	Homo sapiens	96-128
3336010-3	1988	In living PtK2 cells, neomycin dose-dependently inhibited 12-O-tetradecanoyl-phorbol-13-acetate-induced phosphorylation of 88 K Da protein.	Tetradecanoylphorbol Acetate	58-95	focal adhesion kinase 1	Oryctolagus cuniculus	10-14
10495787-5	1997	These increases in ECE-1 and -2 expression with TPA were inhibited by cotreatment with calphostin C (10(-7) M).	Tetradecanoylphorbol Acetate	48-51	endothelin converting enzyme 1	Homo sapiens	19-31
10495787-6	1997	In contrast, 24-h treatment with 10(-7) M TPA significantly decreased the expression of ECE-1 and -2, indicating that the expression was tightly regulated by protein kinase C (PKC)-dependent mechanism(s).	Tetradecanoylphorbol Acetate	42-45	endothelin converting enzyme 1	Homo sapiens	88-100
10495787-7	1997	Actinomycin D (1 microgram/mL) abolished the TPA-induced increase of ECE-1 and -2 mRNA, whereas TPA treatment did not affect the mRNA stability of ECE-1 and -2, thus suggesting that TPA-induced increases of ECE-1 and -2 mRNA resulted from the transcriptional activation of ECE-1 and -2, gene, rather than from the increase of mRNA stability.	Tetradecanoylphorbol Acetate	45-48	endothelin converting enzyme 1	Homo sapiens	69-81
3677097-0	1987	Inhibition of 12-O-tetradecanoylphorbol-13-acetate induction of ornithine decarboxylase activity, DNA synthesis, and tumor promotion in mouse skin by ascorbic acid and ascorbyl palmitate.	Tetradecanoylphorbol Acetate	14-50	ornithine decarboxylase, structural 1	Mus musculus	64-87
3677097-4	1987	The topical application of relatively small doses of ascorbyl palmitate had a marked inhibitory effect on TPA-induced ornithine decarboxylase activity, DNA synthesis, and tumor promotion in mouse epidermis.	Tetradecanoylphorbol Acetate	106-109	ornithine decarboxylase, structural 1	Mus musculus	118-141
9147290-1	1997	GT1-7 cells respond to treatment with the phorbol ester, phorbol 12-myristate 13-acetate (PMA), with an inhibition of transcription of the proGnRH gene and decreases in GnRH mRNA levels.	Tetradecanoylphorbol Acetate	57-88	gonadotropin releasing hormone 1	Mus musculus	142-146
2824029-2	1987	inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo.	Tetradecanoylphorbol Acetate	51-87	ornithine decarboxylase, structural 1	Mus musculus	149-172
2824029-2	1987	inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo.	Tetradecanoylphorbol Acetate	51-87	ornithine decarboxylase, structural 1	Mus musculus	174-177
2824029-2	1987	inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo.	Tetradecanoylphorbol Acetate	89-92	ornithine decarboxylase, structural 1	Mus musculus	149-172
2824029-2	1987	inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo.	Tetradecanoylphorbol Acetate	89-92	ornithine decarboxylase, structural 1	Mus musculus	174-177
3864525-0	1985	Comparison of the inhibitory effects of retinoids on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activities in CD-1 and Sencar mice.	Tetradecanoylphorbol Acetate	53-89	ornithine decarboxylase, structural 1	Mus musculus	108-131
3933814-1	1985	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the non-promoter mezerein both induce ornithine decarboxylase activity in mouse epidermis by a route which can be blocked by indomethacin.	Tetradecanoylphorbol Acetate	19-55	ornithine decarboxylase, structural 1	Mus musculus	104-127
3933814-1	1985	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the non-promoter mezerein both induce ornithine decarboxylase activity in mouse epidermis by a route which can be blocked by indomethacin.	Tetradecanoylphorbol Acetate	57-60	ornithine decarboxylase, structural 1	Mus musculus	104-127
2824029-2	1987	inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo.	Tetradecanoylphorbol Acetate	137-140	ornithine decarboxylase, structural 1	Mus musculus	149-172
2824029-2	1987	inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo.	Tetradecanoylphorbol Acetate	137-140	ornithine decarboxylase, structural 1	Mus musculus	174-177
9147290-1	1997	GT1-7 cells respond to treatment with the phorbol ester, phorbol 12-myristate 13-acetate (PMA), with an inhibition of transcription of the proGnRH gene and decreases in GnRH mRNA levels.	Tetradecanoylphorbol Acetate	90-93	gonadotropin releasing hormone 1	Mus musculus	142-146
2824029-4	1987	DDTC also inhibits the effects of several structurally different tumor promoters and the greater GSH peroxidase and ODC responses produced by repeated TPA treatments.	Tetradecanoylphorbol Acetate	151-154	ornithine decarboxylase, structural 1	Mus musculus	116-119
9202667-5	1997	PMA, which activates PKC delta but not eta, resulted in intracellular pH (pHi) and viability protection, but did not protect against postischemic myocardial stunning.	Tetradecanoylphorbol Acetate	0-3	glucose-6-phosphate isomerase	Rattus norvegicus	74-77
2824029-5	1987	The inhibitory effects of DDTC on TPA-decreased GSH peroxidase and TPA-induced ODC activities are additive with those of Na2SeO3 and D-alpha-tocopherol (vitamin E).	Tetradecanoylphorbol Acetate	34-37	ornithine decarboxylase, structural 1	Mus musculus	79-82
2824029-5	1987	The inhibitory effects of DDTC on TPA-decreased GSH peroxidase and TPA-induced ODC activities are additive with those of Na2SeO3 and D-alpha-tocopherol (vitamin E).	Tetradecanoylphorbol Acetate	67-70	ornithine decarboxylase, structural 1	Mus musculus	79-82
3930615-6	1985	Therefore, TPA probably is not involved in the turnover of PI in these cells but is involved in the activation of PC hydrolyzing phospholipase A2 and PI hydrolyzing phospholipase C in these keratinocytes releasing arachidonic acid which then undergoes oxygenation reactions to provide biologically active eicosanoids.	Tetradecanoylphorbol Acetate	11-14	phospholipase A2, group IB, pancreas	Mus musculus	129-145
2990757-4	1985	Application of alpha- and beta-CBT to mouse skin prior to treatment with TPA inhibited TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	73-76	ornithine decarboxylase, structural 1	Mus musculus	99-102
2990757-4	1985	Application of alpha- and beta-CBT to mouse skin prior to treatment with TPA inhibited TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	87-90	ornithine decarboxylase, structural 1	Mus musculus	99-102
2990757-5	1985	The degree of inhibition was dependent on the dose and application of 16.5 mumol/mouse of alpha- and beta-CBT resulted in a 50 and 40% reduction, respectively, of the maximum of the ODC activity induced as a result of treatment with TPA.	Tetradecanoylphorbol Acetate	233-236	ornithine decarboxylase, structural 1	Mus musculus	182-185
2856403-2	1987	In these basal conditions, the individual addition of TSH, insulin, insulin-like growth factor-I (IGF-I), phorbol 12-myristate 13-acetate (TPA), alpha 1-adrenergic agents, or A23187, increase c-myc and/or c-fos proto-oncogene expression.	Tetradecanoylphorbol Acetate	106-137	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	205-210
9150350-11	1997	However, LPS enhanced the TPA-induced M-CSF production.	Tetradecanoylphorbol Acetate	26-29	colony stimulating factor 1	Homo sapiens	38-43
3689369-2	1987	Staurosporine at the concentrations which exert protein kinase C inhibition, however, failed to inhibit, but markedly augmented 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused ornithine decarboxylase (ODC) induction in isolated mouse epidermal cells.	Tetradecanoylphorbol Acetate	128-164	ornithine decarboxylase, structural 1	Mus musculus	178-201
3689369-2	1987	Staurosporine at the concentrations which exert protein kinase C inhibition, however, failed to inhibit, but markedly augmented 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused ornithine decarboxylase (ODC) induction in isolated mouse epidermal cells.	Tetradecanoylphorbol Acetate	128-164	ornithine decarboxylase, structural 1	Mus musculus	203-206
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	colony stimulating factor 2	Homo sapiens	77-103
3689369-2	1987	Staurosporine at the concentrations which exert protein kinase C inhibition, however, failed to inhibit, but markedly augmented 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused ornithine decarboxylase (ODC) induction in isolated mouse epidermal cells.	Tetradecanoylphorbol Acetate	166-169	ornithine decarboxylase, structural 1	Mus musculus	178-201
3689369-2	1987	Staurosporine at the concentrations which exert protein kinase C inhibition, however, failed to inhibit, but markedly augmented 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused ornithine decarboxylase (ODC) induction in isolated mouse epidermal cells.	Tetradecanoylphorbol Acetate	166-169	ornithine decarboxylase, structural 1	Mus musculus	203-206
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	colony stimulating factor 2	Homo sapiens	105-111
3689369-5	1987	Another protein kinase C inhibitor, H-7, inhibited both staurosporine- and TPA-caused ODC induction.	Tetradecanoylphorbol Acetate	75-78	ornithine decarboxylase, structural 1	Mus musculus	86-89
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	colony stimulating factor 2	Homo sapiens	253-259
9058710-6	1997	Moreover, we found that CD44-mediated adhesion of CD34+ cells to HA could be enhanced by phorbol 12-myristate 13-acetate (PMA), the function-activating anti-CD44 monoclonal antibody H90, and cytokines such as granulocyte-monocyte colony-stimulating factor, interleukin-3 (IL-3), and stem cell factor.	Tetradecanoylphorbol Acetate	122-125	interleukin 3	Homo sapiens	257-270
3477472-0	1987	The bcr-c-abl tyrosine kinase activity is extinguished by TPA in K562 leukemia cells.	Tetradecanoylphorbol Acetate	58-61	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	8-13
3477472-0	1987	The bcr-c-abl tyrosine kinase activity is extinguished by TPA in K562 leukemia cells.	Tetradecanoylphorbol Acetate	58-61	TXK tyrosine kinase	Homo sapiens	14-29
3477472-3	1987	In the present work the activity of the c-abl and c-src oncogene-encoded tyrosine kinase was investigated during phorbol diester (TPA) induced differentiation of the K562 CML cells.	Tetradecanoylphorbol Acetate	130-133	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	40-45
3926337-8	1985	The induction by DMBA of ornithine decarboxylase activity, a biochemical marker of tumor promoter activity, was not affected by CuDIPS; however, induction of ornithine decarboxylase by TPA was potently blocked.	Tetradecanoylphorbol Acetate	185-188	ornithine decarboxylase, structural 1	Mus musculus	158-181
3477472-3	1987	In the present work the activity of the c-abl and c-src oncogene-encoded tyrosine kinase was investigated during phorbol diester (TPA) induced differentiation of the K562 CML cells.	Tetradecanoylphorbol Acetate	130-133	TXK tyrosine kinase	Homo sapiens	73-88
2987348-0	1985	Studies of cytochrome b-245 translocation in the PMA stimulation of the human neutrophil NADPH-oxidase.	Tetradecanoylphorbol Acetate	49-52	mitochondrially encoded cytochrome b	Homo sapiens	11-23
9058710-6	1997	Moreover, we found that CD44-mediated adhesion of CD34+ cells to HA could be enhanced by phorbol 12-myristate 13-acetate (PMA), the function-activating anti-CD44 monoclonal antibody H90, and cytokines such as granulocyte-monocyte colony-stimulating factor, interleukin-3 (IL-3), and stem cell factor.	Tetradecanoylphorbol Acetate	122-125	interleukin 3	Homo sapiens	272-276
2987348-3	1985	Cytochrome b-245 is localized to two pools of specific granules within the beta fraction as assessed by differing sedimentation in narrow Percoll gradients and translocates upon PMA-stimulation from one of these specific granule sub-pools to the plasma membrane where it exhibits no change in its midpoint redox potential.	Tetradecanoylphorbol Acetate	178-181	mitochondrially encoded cytochrome b	Homo sapiens	0-12
3477472-4	1987	The high tyrosine kinase activity of p210bcr-c-abl is strongly reduced during the initial 24 h of TPA treatment.	Tetradecanoylphorbol Acetate	98-101	TXK tyrosine kinase	Homo sapiens	9-24
3477472-4	1987	The high tyrosine kinase activity of p210bcr-c-abl is strongly reduced during the initial 24 h of TPA treatment.	Tetradecanoylphorbol Acetate	98-101	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	45-50
9054402-2	1997	We have used the HL-60 cell line to study regulation of p27 as cells withdraw from the cell cycle following treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	123-159	interferon alpha inducible protein 27	Homo sapiens	56-59
2820605-0	1987	Decreased stimulation by 12-O-tetradecanoylphorbol-13-acetate of superoxide radical production by polymorphonuclear leukocytes carrying the Mediterranean variant of glucose-6-phosphate dehydrogenase.	Tetradecanoylphorbol Acetate	25-61	glucose-6-phosphate dehydrogenase	Homo sapiens	165-198
3887183-3	1985	Here, we show that the TPA (12-O-tetradecanoylphorbol-13-acetate)-induced macrophage-like differentiation of HL60 human promyelocytic precursor cells is accompanied by the induction of both c-fos mRNA and protein within 15 min after treatment, suggesting a functional role for c-fos in this differentiation system.	Tetradecanoylphorbol Acetate	23-26	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	190-195
9054402-2	1997	We have used the HL-60 cell line to study regulation of p27 as cells withdraw from the cell cycle following treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	161-164	interferon alpha inducible protein 27	Homo sapiens	56-59
3887183-3	1985	Here, we show that the TPA (12-O-tetradecanoylphorbol-13-acetate)-induced macrophage-like differentiation of HL60 human promyelocytic precursor cells is accompanied by the induction of both c-fos mRNA and protein within 15 min after treatment, suggesting a functional role for c-fos in this differentiation system.	Tetradecanoylphorbol Acetate	23-26	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	277-282
3887183-3	1985	Here, we show that the TPA (12-O-tetradecanoylphorbol-13-acetate)-induced macrophage-like differentiation of HL60 human promyelocytic precursor cells is accompanied by the induction of both c-fos mRNA and protein within 15 min after treatment, suggesting a functional role for c-fos in this differentiation system.	Tetradecanoylphorbol Acetate	28-64	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	190-195
3887183-3	1985	Here, we show that the TPA (12-O-tetradecanoylphorbol-13-acetate)-induced macrophage-like differentiation of HL60 human promyelocytic precursor cells is accompanied by the induction of both c-fos mRNA and protein within 15 min after treatment, suggesting a functional role for c-fos in this differentiation system.	Tetradecanoylphorbol Acetate	28-64	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	277-282
2820819-8	1987	We now show that purified ZP3 from 12-O-tetradecanoyl phorbol-13-acetate (TPA)-treated eggs possesses full sperm receptor activity but has lost its ability to induce a complete acrosome reaction.	Tetradecanoylphorbol Acetate	35-72	zona pellucida glycoprotein 3	Mus musculus	26-29
2820819-8	1987	We now show that purified ZP3 from 12-O-tetradecanoyl phorbol-13-acetate (TPA)-treated eggs possesses full sperm receptor activity but has lost its ability to induce a complete acrosome reaction.	Tetradecanoylphorbol Acetate	74-77	zona pellucida glycoprotein 3	Mus musculus	26-29
2820819-9	1987	The modification of the acrosome reaction-inducing activity of ZP3 from these TPA-treated eggs differs from ZP3 isolated from two-cell embryos, which cannot initiate the acrosome reaction.	Tetradecanoylphorbol Acetate	78-81	zona pellucida glycoprotein 3	Mus musculus	63-66
9250394-0	1997	The protein kinase inhibitor SB203580 uncouples PMA-induced differentiation of HL-60 cells from phosphorylation of Hsp27.	Tetradecanoylphorbol Acetate	48-51	heat shock protein family B (small) member 1	Homo sapiens	115-120
3498751-0	1987	Selective down modulation of L3T4 molecules on murine thymocytes by the tumor promoter, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	88-119	CD4 antigen	Mus musculus	29-33
3498751-1	1987	Treatment of murine thymocytes, but not mature peripheral T cells, with the tumor promoter, phorbol 12-myristate 13-acetate (PMA), 3 results in a rapid disappearance of L3T4 molecules from the surface of thymocytes.	Tetradecanoylphorbol Acetate	92-123	CD4 antigen	Mus musculus	169-173
9250394-5	1997	As a result, PMA-induced Hsp27 phosphorylation is inhibited in SB 203580-treated HL-60 cells indicating that p38RK and MAPKAP kinase 2 are components of the PMA-induced signal transduction pathway leading to Hsp27 phosphorylation.	Tetradecanoylphorbol Acetate	13-16	heat shock protein family B (small) member 1	Homo sapiens	25-30
3498751-1	1987	Treatment of murine thymocytes, but not mature peripheral T cells, with the tumor promoter, phorbol 12-myristate 13-acetate (PMA), 3 results in a rapid disappearance of L3T4 molecules from the surface of thymocytes.	Tetradecanoylphorbol Acetate	125-128	CD4 antigen	Mus musculus	169-173
9250394-5	1997	As a result, PMA-induced Hsp27 phosphorylation is inhibited in SB 203580-treated HL-60 cells indicating that p38RK and MAPKAP kinase 2 are components of the PMA-induced signal transduction pathway leading to Hsp27 phosphorylation.	Tetradecanoylphorbol Acetate	13-16	heat shock protein family B (small) member 1	Homo sapiens	208-213
2859127-1	1985	The constituent amino acids of reduced glutathione (GSH), GSH itself, and D-alpha-tocopherol inhibited 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC, L-ornithine carboxy-lyase, EC 4.1.1.17) activity in mouse epidermis in vivo and in vitro.	Tetradecanoylphorbol Acetate	142-145	ornithine decarboxylase, structural 1	Mus musculus	155-178
9250394-5	1997	As a result, PMA-induced Hsp27 phosphorylation is inhibited in SB 203580-treated HL-60 cells indicating that p38RK and MAPKAP kinase 2 are components of the PMA-induced signal transduction pathway leading to Hsp27 phosphorylation.	Tetradecanoylphorbol Acetate	157-160	heat shock protein family B (small) member 1	Homo sapiens	25-30
2859127-1	1985	The constituent amino acids of reduced glutathione (GSH), GSH itself, and D-alpha-tocopherol inhibited 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC, L-ornithine carboxy-lyase, EC 4.1.1.17) activity in mouse epidermis in vivo and in vitro.	Tetradecanoylphorbol Acetate	142-145	ornithine decarboxylase, structural 1	Mus musculus	180-183
2859127-3	1985	Moreover, the ability of the constituent amino acids of GSH and GSH to inhibit TPA-induced ODC activity correlated well with their ability to increase the ratio of GSH/oxidized glutathione (GSSG) in isolated epidermal cells.	Tetradecanoylphorbol Acetate	79-82	ornithine decarboxylase, structural 1	Mus musculus	91-94
3629608-5	1987	Myeloperoxidase activity, a marker for neutrophils, increased 15-fold in the skin by 16 hr after TPA treatment.	Tetradecanoylphorbol Acetate	97-100	myeloperoxidase	Mus musculus	0-15
3654756-4	1987	There are differences in where, when, and how myofibrillar alpha-actin and MHC are degraded and eliminated from TPA-myosacs.	Tetradecanoylphorbol Acetate	112-115	major histocompatibility complex, class I, C	Homo sapiens	75-78
9250394-5	1997	As a result, PMA-induced Hsp27 phosphorylation is inhibited in SB 203580-treated HL-60 cells indicating that p38RK and MAPKAP kinase 2 are components of the PMA-induced signal transduction pathway leading to Hsp27 phosphorylation.	Tetradecanoylphorbol Acetate	157-160	heat shock protein family B (small) member 1	Homo sapiens	208-213
3654756-16	1987	TPA reversibly blocks incorporation of [35S]methionine into myofibrillar alpha-actin, MHC, myosin light chains 1 and 2, the tropomyosins, and troponin C. It does not block the synthesis of beta- or gamma-actins, the nonmyofibrillar MHC or light chains, tubulin, vimentin, desmin, or most household molecules.	Tetradecanoylphorbol Acetate	0-3	major histocompatibility complex, class I, C	Homo sapiens	86-89
2859127-5	1985	Since the inhibitory effects of Cys on both the decrease in the ratio of GSH/GSSG and the induction of ODC activity by TPA were greatly reduced by the inhibitors of gamma-glutamyl transpeptidase and gamma-glutamylcysteine synthetase, it is suggested that some of the inhibitory effects of Glu, Cys and Gly on tumor promotion could result from their interference with the metabolism of the tripeptide GSH, a natural antioxidant which inhibits chemical carcinogenesis.	Tetradecanoylphorbol Acetate	119-122	ornithine decarboxylase, structural 1	Mus musculus	103-106
3654756-16	1987	TPA reversibly blocks incorporation of [35S]methionine into myofibrillar alpha-actin, MHC, myosin light chains 1 and 2, the tropomyosins, and troponin C. It does not block the synthesis of beta- or gamma-actins, the nonmyofibrillar MHC or light chains, tubulin, vimentin, desmin, or most household molecules.	Tetradecanoylphorbol Acetate	0-3	major histocompatibility complex, class I, C	Homo sapiens	232-235
9048588-4	1997	On the other hand, epidermal growth factor (EGF), Ca ionophore, the protein kinase C activator 12-O-tetradecanoylphorbol-13-acetate (TPA), and cAMP elevated 17HSD type 1 expression only in JEG-3 cells.	Tetradecanoylphorbol Acetate	133-136	epidermal growth factor	Homo sapiens	19-42
3329719-4	1987	In contrast, in v-ras-transformed rat thyroid cells, which express very high levels of p21, treatment with either TSH, forskolin or TPA does not induce c-fos gene expression, while c-myc expression was constitutive.	Tetradecanoylphorbol Acetate	132-135	KRAS proto-oncogene, GTPase	Rattus norvegicus	87-90
3301843-7	1987	The phorbol ester phorbol 12-myristate 13-acetate (PMA) also induces c-myc and c-fos mRNAs without inducing DNA synthesis.	Tetradecanoylphorbol Acetate	18-49	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	79-84
3301843-7	1987	The phorbol ester phorbol 12-myristate 13-acetate (PMA) also induces c-myc and c-fos mRNAs without inducing DNA synthesis.	Tetradecanoylphorbol Acetate	51-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	79-84
3301843-8	1987	However, the mechanism of this induction appears to be different from the insulin-induced induction since pretreatment of cells with PMA blocks only the PMA-mediated, not the insulin-mediated, induction of c-myc and c-fos.	Tetradecanoylphorbol Acetate	133-136	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	216-221
3921276-3	1985	The expression of abl was reduced in both papillomas and carcinomas and after repeated applications of 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	103-139	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	18-21
3921276-3	1985	The expression of abl was reduced in both papillomas and carcinomas and after repeated applications of 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	141-144	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	18-21
3921276-7	1985	The lower level of expression of abl in tumors and after repeated applications of TPA may indicate a role for this gene in some aspect of epidermal proliferation or differentiation.	Tetradecanoylphorbol Acetate	82-85	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	33-36
3995502-0	1985	Inhibition of the effects of 12-O-tetradecanoylphorbol-13-acetate on mouse epidermal glutathione peroxidase and ornithine decarboxylase activities by glutathione level-raising agents and selenium-containing compounds.	Tetradecanoylphorbol Acetate	29-65	ornithine decarboxylase, structural 1	Mus musculus	112-135
9155647-9	1997	When phorbol 12-myristate 13-acetate (PMA) was added to the cells triggered with CD2 + 28mAbs, the responses examined were enhanced in both cord and adult blood with no significant differences between the groups.	Tetradecanoylphorbol Acetate	5-36	CD2 molecule	Homo sapiens	81-84
3995502-3	1985	The inhibitory effects of 0.2 mM cysteine (Cys) or 0.5 mM GSH and 2.5 microM Na2 SeO3 or 50 microM selenocystamine on TPA-decreased GSH peroxidase activity were additive, in relation with their additive inhibitory effects on TPA-induced ornithine decarboxylase (ODC) (L-ornithine carboxylase, EC 4.1.1.17) activity.	Tetradecanoylphorbol Acetate	118-121	ornithine decarboxylase, structural 1	Mus musculus	237-260
3995502-3	1985	The inhibitory effects of 0.2 mM cysteine (Cys) or 0.5 mM GSH and 2.5 microM Na2 SeO3 or 50 microM selenocystamine on TPA-decreased GSH peroxidase activity were additive, in relation with their additive inhibitory effects on TPA-induced ornithine decarboxylase (ODC) (L-ornithine carboxylase, EC 4.1.1.17) activity.	Tetradecanoylphorbol Acetate	118-121	ornithine decarboxylase, structural 1	Mus musculus	262-265
2442709-4	1987	IP3 and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination, stimulated an additive secretion of mucin in the model.	Tetradecanoylphorbol Acetate	26-62	solute carrier family 13 member 2	Rattus norvegicus	121-126
2442709-4	1987	IP3 and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination, stimulated an additive secretion of mucin in the model.	Tetradecanoylphorbol Acetate	64-67	solute carrier family 13 member 2	Rattus norvegicus	121-126
9155647-9	1997	When phorbol 12-myristate 13-acetate (PMA) was added to the cells triggered with CD2 + 28mAbs, the responses examined were enhanced in both cord and adult blood with no significant differences between the groups.	Tetradecanoylphorbol Acetate	38-41	CD2 molecule	Homo sapiens	81-84
21533395-3	1997	CAL-A (0.5 nM) and OKA (2 nM), cell permeable inhibitors of PP1 and PP2A, augmented TNF alpha-induced TF expression, although TF expression induced by either TPA or thrombin was unchanged in the presence of GAL-A.	Tetradecanoylphorbol Acetate	158-161	coagulation factor III, tissue factor	Homo sapiens	126-128
2884032-5	1987	These agents are very potent inhibitors of growth of melanoma S91 cells and inhibit the induction of ornithine decarboxylase activity by phorbol 12-myristate 13-acetate in 3T6 fibroblasts.	Tetradecanoylphorbol Acetate	137-168	ornithine decarboxylase, structural 1	Mus musculus	101-124
3970689-2	1985	In vitro, the addition of 12-0-tetradecanoylphorbol-13-acetate (TPA) to adult mouse skin pieces incubated at 37 degrees C in serum-free MEM led to a dramatic increase in epidermal ODC activity 5 hours following treatment.	Tetradecanoylphorbol Acetate	64-67	ornithine decarboxylase, structural 1	Mus musculus	180-183
3628203-7	1987	By contrast, the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), and the DAG derivative, 1-oleoyl-2-acetylglycerol (OAG), increased soluble PKC in vitro twofold.	Tetradecanoylphorbol Acetate	33-69	protein kinase C, gamma	Rattus norvegicus	152-155
21533428-5	1997	Instead, PMA treatment led to reduced phosphorylation of p53.	Tetradecanoylphorbol Acetate	9-12	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	57-60
3628203-7	1987	By contrast, the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), and the DAG derivative, 1-oleoyl-2-acetylglycerol (OAG), increased soluble PKC in vitro twofold.	Tetradecanoylphorbol Acetate	71-74	protein kinase C, gamma	Rattus norvegicus	152-155
3628203-10	1987	TPA and OAG caused similar shifts in the subcellular distribution of PKC but did not stimulate DAG release, whereas phorbol and 4 alpha PDD were without effect on any parameter.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, gamma	Rattus norvegicus	69-72
3628203-11	1987	In vivo intracolonic instillation of DOC, OAG, or TPA each induced a shift of soluble PKC to the particulate fraction of colonic mucosal scrapings.	Tetradecanoylphorbol Acetate	50-53	protein kinase C, gamma	Rattus norvegicus	86-89
2981092-0	1985	Biochemical models of gamma-interferon action: altered expression of transferrin receptors on murine peritoneal macrophages after treatment in vitro with PMA or A23187.	Tetradecanoylphorbol Acetate	154-157	transferrin	Mus musculus	69-80
2981092-3	1985	We observed that the downshift of the transferrin receptor could be mimicked by exposure to the calcium ionophore (A23187) or the potent tumor promoter, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	153-184	transferrin	Mus musculus	38-49
2981092-3	1985	We observed that the downshift of the transferrin receptor could be mimicked by exposure to the calcium ionophore (A23187) or the potent tumor promoter, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	186-189	transferrin	Mus musculus	38-49
2981092-4	1985	Saturation binding studies on thioglycollate (TG)-elicited peritoneal macrophages after exposure to A23187 or PMA showed the reduced expression of transferrin binding activity attributable to a decrease in the total number of cellular transferrin receptors and not an alteration in receptor-ligand affinity, in agreement with previous results obtained after exposure to IFN gamma.	Tetradecanoylphorbol Acetate	110-113	transferrin	Mus musculus	147-158
9125669-4	1997	IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide.	Tetradecanoylphorbol Acetate	131-134	interleukin 1 alpha	Homo sapiens	0-4
2981092-4	1985	Saturation binding studies on thioglycollate (TG)-elicited peritoneal macrophages after exposure to A23187 or PMA showed the reduced expression of transferrin binding activity attributable to a decrease in the total number of cellular transferrin receptors and not an alteration in receptor-ligand affinity, in agreement with previous results obtained after exposure to IFN gamma.	Tetradecanoylphorbol Acetate	110-113	transferrin	Mus musculus	235-246
9125669-4	1997	IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide.	Tetradecanoylphorbol Acetate	227-230	interleukin 1 alpha	Homo sapiens	0-4
3034433-0	1987	Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements.	Tetradecanoylphorbol Acetate	50-53	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-34
3034433-5	1987	Here we demonstrate that multiple synthetic copies of the consensus AP-1-binding site can act as TPA-inducible enhancers in various plasmid constructs after transfection into HeLa cells.	Tetradecanoylphorbol Acetate	97-100	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-72
3034433-6	1987	These findings suggest that AP-1 is a transcription factor that functions by interacting with a specific enhancer element, and that its activities may be modulated by treatment of cells with TPA, known to stimulate protein kinase C.	Tetradecanoylphorbol Acetate	191-194	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-32
9115586-9	1997	Analysis of cellular proliferation in both DMBA-TPA-induced papillomas and in skin 48 h after TPA treatment alone revealed significantly more DNA synthesis in TGF alpha-transgenic mice relative to controls.	Tetradecanoylphorbol Acetate	48-51	transforming growth factor alpha	Mus musculus	159-168
3107806-8	1987	Indomethacin was found to inhibit TPA-induced ornithine decarboxylase activity to the same extent in both mice.	Tetradecanoylphorbol Acetate	34-37	ornithine decarboxylase, structural 1	Mus musculus	46-69
9115586-10	1997	These results demonstrate that TGF alpha, through EGFR overstimulation, can act synergistically with TPA to induce the formation, growth, and development of DMBA-initiated skin tumors containing classic Ha-ras gene mutations but not p53 gene inactivation.	Tetradecanoylphorbol Acetate	101-104	transforming growth factor alpha	Mus musculus	31-40
9065796-0	1997	Coordinated expression of matrilysin during TPA-induced apoptosis of LNCaP cells: two parallel processes affected by TPA.	Tetradecanoylphorbol Acetate	44-47	matrix metallopeptidase 7	Homo sapiens	26-36
3494505-17	1987	These results suggest that TPA may not directly induce the growth of M12 cells or the formation of colonies of bone marrow cells, but instead may act through the induction of a non-CSF-1 growth factor.	Tetradecanoylphorbol Acetate	27-30	colony stimulating factor 1 (macrophage)	Mus musculus	181-186
9065796-0	1997	Coordinated expression of matrilysin during TPA-induced apoptosis of LNCaP cells: two parallel processes affected by TPA.	Tetradecanoylphorbol Acetate	117-120	matrix metallopeptidase 7	Homo sapiens	26-36
3034291-4	1987	We confirm and extend the fact that these beta-adrenoceptors are of the beta 2-subtype, using selective ligands, photoaffinity labeling with [125I]CYP-diazirine identified two protein subunits: p59 and p72, the beta 2-adrenoceptor dependent adenylate cyclase desensitizes with half-life of 2.2 +/- 0.3 min whereas the loss of [125I]CYP binding from the cell surface requires longer exposure times to the agonist, phorbol-12-myristate-13-acetate (PMA) has no effect on the desensitization process nor does it have any effect on the modulation of beta-agonist affinity by guanyl nucleotides.	Tetradecanoylphorbol Acetate	413-444	HLA complex P5B	Homo sapiens	194-197
9065796-1	1997	Matrix metalloproteinases (MMPs) are upregulated by growth factors and 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	71-108	matrix metallopeptidase 7	Homo sapiens	27-31
3034291-4	1987	We confirm and extend the fact that these beta-adrenoceptors are of the beta 2-subtype, using selective ligands, photoaffinity labeling with [125I]CYP-diazirine identified two protein subunits: p59 and p72, the beta 2-adrenoceptor dependent adenylate cyclase desensitizes with half-life of 2.2 +/- 0.3 min whereas the loss of [125I]CYP binding from the cell surface requires longer exposure times to the agonist, phorbol-12-myristate-13-acetate (PMA) has no effect on the desensitization process nor does it have any effect on the modulation of beta-agonist affinity by guanyl nucleotides.	Tetradecanoylphorbol Acetate	446-449	HLA complex P5B	Homo sapiens	194-197
9065796-1	1997	Matrix metalloproteinases (MMPs) are upregulated by growth factors and 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	110-113	matrix metallopeptidase 7	Homo sapiens	27-31
3581045-5	1987	The inhibition of TPA action was shown not to be restricted to DNA synthesis in 3T3 cultured cells since the sialoglycopeptide also inhibited TPA-induced ornithine decarboxylase (ODC, L-ornithine carboxylase, EC 4.1.1.17) activation in suspensions of mouse epidermal and 3T3 cells.	Tetradecanoylphorbol Acetate	18-21	ornithine decarboxylase, structural 1	Mus musculus	154-177
9065796-2	1997	TPA (10 nM) induced apoptosis in LNCaP cells grown in serum-free medium at high seeding density, and increased mRNA and secreted protein levels for the MMP matrilysin.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 7	Homo sapiens	156-166
9065796-3	1997	While the TPA-augmented increase in matrilysin mRNA was seen at 4 h, secreted matrilysin protein levels at 8 h, TPA-induced DNA ladder formation was seen only at 10 h and the TPA-induced apoptosis was detected at 12 h. The sequence of events suggested a functional role for matrilysin in apoptosis.	Tetradecanoylphorbol Acetate	10-13	matrix metallopeptidase 7	Homo sapiens	36-46
9065796-3	1997	While the TPA-augmented increase in matrilysin mRNA was seen at 4 h, secreted matrilysin protein levels at 8 h, TPA-induced DNA ladder formation was seen only at 10 h and the TPA-induced apoptosis was detected at 12 h. The sequence of events suggested a functional role for matrilysin in apoptosis.	Tetradecanoylphorbol Acetate	10-13	matrix metallopeptidase 7	Homo sapiens	78-88
3475202-6	1987	The PDGF-A and B-chain (c-sis) RNA expression as well as secretion of PDGF polypeptides are induced in the K562 cell line upon induction of megakaryoblastic differentiation with 12-O-tetradecanoyl phorbol-13-acetate (TPA) whereas erythroid differentiation induced with sodium butyrate is accompanied by c-sis expression only.	Tetradecanoylphorbol Acetate	178-215	platelet derived growth factor subunit B	Homo sapiens	24-29
9065796-3	1997	While the TPA-augmented increase in matrilysin mRNA was seen at 4 h, secreted matrilysin protein levels at 8 h, TPA-induced DNA ladder formation was seen only at 10 h and the TPA-induced apoptosis was detected at 12 h. The sequence of events suggested a functional role for matrilysin in apoptosis.	Tetradecanoylphorbol Acetate	10-13	matrix metallopeptidase 7	Homo sapiens	78-88
3475202-6	1987	The PDGF-A and B-chain (c-sis) RNA expression as well as secretion of PDGF polypeptides are induced in the K562 cell line upon induction of megakaryoblastic differentiation with 12-O-tetradecanoyl phorbol-13-acetate (TPA) whereas erythroid differentiation induced with sodium butyrate is accompanied by c-sis expression only.	Tetradecanoylphorbol Acetate	217-220	platelet derived growth factor subunit A	Homo sapiens	4-22
3475202-6	1987	The PDGF-A and B-chain (c-sis) RNA expression as well as secretion of PDGF polypeptides are induced in the K562 cell line upon induction of megakaryoblastic differentiation with 12-O-tetradecanoyl phorbol-13-acetate (TPA) whereas erythroid differentiation induced with sodium butyrate is accompanied by c-sis expression only.	Tetradecanoylphorbol Acetate	217-220	platelet derived growth factor subunit B	Homo sapiens	24-29
9065796-6	1997	We conclude that the TPA-induced apoptosis and the regulation of matrilysin (a TPA-response element (TRE)-containing gene), are independent and parallel processes.	Tetradecanoylphorbol Acetate	21-24	matrix metallopeptidase 7	Homo sapiens	65-75
9065796-6	1997	We conclude that the TPA-induced apoptosis and the regulation of matrilysin (a TPA-response element (TRE)-containing gene), are independent and parallel processes.	Tetradecanoylphorbol Acetate	79-82	matrix metallopeptidase 7	Homo sapiens	65-75
9037208-5	1997	We also demonstrate the u-PA treatment potentiated phorbol ester (PMA)-mediated induction of PAI-2 mRNA, indicating that u-PA binding produces a bone fide response in vivo.	Tetradecanoylphorbol Acetate	66-69	serpin family B member 2	Homo sapiens	93-98
3032687-3	1987	The order of potency of the phosphoinositides in the activation of PKC, PI greater than PI 4P greater than PI 4,5DP, shows a negative correlation with the degree of acidity of the phospholipid head group, whether 1 mM Ca2+ or 200 nM TPA is present in the reaction assay mixture.	Tetradecanoylphorbol Acetate	233-236	protein kinase C, gamma	Rattus norvegicus	67-70
3029099-1	1987	HeLa cells synthesize and secrete increased levels of tissue plasminogen activator (tPA) when incubated for 18 h with 10-20 nM phorbol myristate acetate.	Tetradecanoylphorbol Acetate	127-152	chromosome 20 open reading frame 181	Homo sapiens	54-82
9028336-8	1997	The simultaneous treatment of the cells with GM-CSF and phorbol esters such as phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu) significantly inhibited both the tyrosine phosphorylation of p85 and the activation of PI3-kinase.	Tetradecanoylphorbol Acetate	79-110	colony stimulating factor 2	Homo sapiens	45-51
3558493-5	1987	Pretreatment of cells with phorbol-12, 13-dibutyrate (PDBu) for 24 h depleted cellular protein kinase C activity and inhibited the ability of TPA to induce these effects suggesting a direct involvement of protein kinase C. Similarly the bombesin stimulation of 32Pi into PC and of [3H]choline and [3H]phosphocholine release was inhibited by PDBu pretreatment.	Tetradecanoylphorbol Acetate	142-145	gastrin releasing peptide	Homo sapiens	237-245
9028336-8	1997	The simultaneous treatment of the cells with GM-CSF and phorbol esters such as phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu) significantly inhibited both the tyrosine phosphorylation of p85 and the activation of PI3-kinase.	Tetradecanoylphorbol Acetate	112-115	colony stimulating factor 2	Homo sapiens	45-51
9065603-5	1997	Incubation with phorbol-12-myristate-13-acetate led to a significant increase (p &lt; 0.005) of LDL-R mRNA in ER+ cells, whereas in ER- cells LDL-R mRNA levels remained merely unchanged.	Tetradecanoylphorbol Acetate	16-47	low density lipoprotein receptor	Homo sapiens	96-101
3546293-1	1987	The effect of phorbol 12-myristate 13-acetate on the phosphorylation of the ras p21 protein was studied by metabolically labeling cultured cells with [32P]orthophosphate and using a monoclonal antibody to immunoprecipitate the protein.	Tetradecanoylphorbol Acetate	14-45	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	80-83
9024778-8	1997	The degradation of FN is blocked by either serine protease inhibitors or goat anti-human tPA.	Tetradecanoylphorbol Acetate	89-92	fibronectin 1	Mus musculus	19-21
3546293-2	1987	Phorbol 12-myristate 13-acetate (100 nM) induced phosphorylation of cKi-ras p21 in a mouse adrenocortical cell line (Yl) expressing high levels of cKi-ras with exon 4B.	Tetradecanoylphorbol Acetate	0-31	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	76-79
3297041-0	1987	Stimulation of adipocyte phospholipid methyltransferase activity by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	68-99	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	25-55
9024778-9	1997	Our data suggest that enhanced production of tPA during PE outgrowth may facilitate the migratory behavior of PE cells by mediating the degradation of ECM components such as FN.	Tetradecanoylphorbol Acetate	45-48	fibronectin 1	Mus musculus	174-176
3297041-2	1987	The present studies demonstrate that treatment of rat adipocytes with the phorbol ester phorbol 12-myristate 13-acetate (PMA) causes a dose-dependent stimulation of phospholipid methyltransferase (PLMT) activity.	Tetradecanoylphorbol Acetate	88-119	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	165-195
3297041-2	1987	The present studies demonstrate that treatment of rat adipocytes with the phorbol ester phorbol 12-myristate 13-acetate (PMA) causes a dose-dependent stimulation of phospholipid methyltransferase (PLMT) activity.	Tetradecanoylphorbol Acetate	88-119	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	197-201
9157598-3	1997	Differentiation of MEG-01 cells induced by 100 nM 12-O-tetradecanoylphorbol-13-acetate revealed the considerable increases in mRNA expression of rap1B, rab3B, rab4, ram and ran whereas the levels of rap2B, rhoA and rac1 decreased.	Tetradecanoylphorbol Acetate	50-86	RAB3B, member RAS oncogene family	Homo sapiens	152-157
3297041-2	1987	The present studies demonstrate that treatment of rat adipocytes with the phorbol ester phorbol 12-myristate 13-acetate (PMA) causes a dose-dependent stimulation of phospholipid methyltransferase (PLMT) activity.	Tetradecanoylphorbol Acetate	121-124	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	165-195
3297041-2	1987	The present studies demonstrate that treatment of rat adipocytes with the phorbol ester phorbol 12-myristate 13-acetate (PMA) causes a dose-dependent stimulation of phospholipid methyltransferase (PLMT) activity.	Tetradecanoylphorbol Acetate	121-124	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	197-201
2948635-5	1987	Nuclear run-on assays showed that E1 transcription, as well as transcription of c-fos, c-myc, and beta-actin was stimulated in 293 cells within 30 min of TPA exposure and returned to basal levels by 60 min.	Tetradecanoylphorbol Acetate	154-157	POTE ankyrin domain family member F	Homo sapiens	98-108
9157598-3	1997	Differentiation of MEG-01 cells induced by 100 nM 12-O-tetradecanoylphorbol-13-acetate revealed the considerable increases in mRNA expression of rap1B, rab3B, rab4, ram and ran whereas the levels of rap2B, rhoA and rac1 decreased.	Tetradecanoylphorbol Acetate	50-86	RAP2B, member of RAS oncogene family	Homo sapiens	199-204
9008448-2	1997	BACKGROUND: TNK-tissue plasminogen activator (TNK-TPA) is a genetically engineered variant of TPA, which in experimental models has a slower plasma clearance and greater fibrin specificity and is 80-fold more resistant to plasminogen activator inhibitor-1 than alteplase TPA.	Tetradecanoylphorbol Acetate	50-53	serpin family E member 1	Homo sapiens	222-255
3028401-3	1987	Enhanced activity is predominantly seen in oxidoreductase-rich 27,000 X g membrane preparations obtained from phorbol myristate acetate activated cells.	Tetradecanoylphorbol Acetate	110-135	thioredoxin reductase 1	Homo sapiens	43-57
9008448-2	1997	BACKGROUND: TNK-tissue plasminogen activator (TNK-TPA) is a genetically engineered variant of TPA, which in experimental models has a slower plasma clearance and greater fibrin specificity and is 80-fold more resistant to plasminogen activator inhibitor-1 than alteplase TPA.	Tetradecanoylphorbol Acetate	94-97	serpin family E member 1	Homo sapiens	222-255
3101510-5	1987	12-O-tetradecanoylphorbol-13-acetate (TPA) inhibited binding of CCK in the same manner as carbamylcholine.	Tetradecanoylphorbol Acetate	0-36	cholecystokinin	Rattus norvegicus	64-67
9332492-2	1997	Our data show that TPA and TNF stimulate an immediate and massive phosphorylation of HSP27, whereas OH-TAM affect the phosphorylation status of the protein only after a 3 day delay.	Tetradecanoylphorbol Acetate	19-22	heat shock protein family B (small) member 1	Homo sapiens	85-90
3101510-5	1987	12-O-tetradecanoylphorbol-13-acetate (TPA) inhibited binding of CCK in the same manner as carbamylcholine.	Tetradecanoylphorbol Acetate	38-41	cholecystokinin	Rattus norvegicus	64-67
3101510-7	1987	By contrast, inhibition of binding of CCK by TPA did not reverse after a 60-min incubation without the agent.	Tetradecanoylphorbol Acetate	45-48	cholecystokinin	Rattus norvegicus	38-41
3101510-9	1987	The action of TPA on binding of CCK suggests the possible involvement of the activation of protein kinase C in the inhibition of binding.	Tetradecanoylphorbol Acetate	14-17	cholecystokinin	Rattus norvegicus	32-35
9332492-3	1997	In the case of TPA, high levels of HSP27 phosphorylation were maintained for at least 4 days, along with growth inhibition and acquisition by the cells of a secretory phenotype.	Tetradecanoylphorbol Acetate	15-18	heat shock protein family B (small) member 1	Homo sapiens	35-40
3476168-0	1987	Phenotypic modulation of chronic lymphocytic, prolymphocytic, and lymphoplasmacytic leukemia cells by TPA: induction of TRAP isoenzyme 5 and HD6 (CD22) antigen and enhancement of IgM messenger RNA.	Tetradecanoylphorbol Acetate	102-105	defensin alpha 6	Homo sapiens	141-144
9332492-4	1997	TPA and OH-TAM exerted similar immediated effects on cell growth, despite the different time course of their action on HSP27 phosphorylation.	Tetradecanoylphorbol Acetate	0-3	heat shock protein family B (small) member 1	Homo sapiens	119-124
9202885-6	1997	Distinct regions of the proximal promoter respond to a wide array of signals such as phorbol myristate acetate (PMA) and Ca2+ ionophore or phytohemaglutinin (PHA), CD28 activation, human T leukemia virus (HTLV)-1 tax, TNF, and interleukin 1 (IL-1).	Tetradecanoylphorbol Acetate	112-115	interleukin 1 alpha	Homo sapiens	227-246
9034205-3	1997	After stimulation, PMA-treated THP-1 cells showed not only a 40-fold increase in 125I-labeled LDL binding but also a 40-fold increase in the immunoreactive LDL-R protein, confirming that the increase in LDL binding is due to an increase LDL-R number.	Tetradecanoylphorbol Acetate	19-22	low density lipoprotein receptor	Homo sapiens	156-161
9034205-3	1997	After stimulation, PMA-treated THP-1 cells showed not only a 40-fold increase in 125I-labeled LDL binding but also a 40-fold increase in the immunoreactive LDL-R protein, confirming that the increase in LDL binding is due to an increase LDL-R number.	Tetradecanoylphorbol Acetate	19-22	low density lipoprotein receptor	Homo sapiens	237-242
8972184-3	1997	Deletion of the Raf zinc finger and replacement with a homologous zinc finger from protein kinase C gamma (PKC gamma) (to give gamma/Raf) also abrogates EGF-induced activation but enables a vigorous phorbol myristate acetate (PMA)-induced activation.	Tetradecanoylphorbol Acetate	199-224	protein kinase C gamma	Homo sapiens	107-116
8972184-3	1997	Deletion of the Raf zinc finger and replacement with a homologous zinc finger from protein kinase C gamma (PKC gamma) (to give gamma/Raf) also abrogates EGF-induced activation but enables a vigorous phorbol myristate acetate (PMA)-induced activation.	Tetradecanoylphorbol Acetate	226-229	protein kinase C gamma	Homo sapiens	107-116
9586065-2	1997	EGF increased the binding activity in nuclear extracts of MC3T3-E1 cells to TPA-responsive element (TRE).	Tetradecanoylphorbol Acetate	76-79	epidermal growth factor	Mus musculus	0-3
9443649-4	1997	However, when phorbol myristate acetate (PMA)-activated T lymphocytes, which express lymphocyte function-associated antigen-1 (LFA-1), were cocultured with tumor cells, attachment of S20 increased twofold (60 +/- 11.9%) but AS6 showed no change (32 +/- 11%).	Tetradecanoylphorbol Acetate	14-39	ribosomal protein S20	Homo sapiens	183-186
9443649-4	1997	However, when phorbol myristate acetate (PMA)-activated T lymphocytes, which express lymphocyte function-associated antigen-1 (LFA-1), were cocultured with tumor cells, attachment of S20 increased twofold (60 +/- 11.9%) but AS6 showed no change (32 +/- 11%).	Tetradecanoylphorbol Acetate	41-44	ribosomal protein S20	Homo sapiens	183-186
9000129-10	1996	Sequences homologous to uCOM are found in the promoters of other inducible genes, coding for proteases, cytokines and chemokines: for example, in the promoter of the MIP-1alpha/LD78 chemokine gene, a 15/18 nucleotides identity is found in a region mediating positive and negative functions in TPA induction.	Tetradecanoylphorbol Acetate	293-296	C-C motif chemokine ligand 3	Homo sapiens	166-176
8955185-5	1996	The proliferative response of LFA-1 -/- splenocytes following stimulation by LPS, PMA plus ionomycin, or immobilized anti-CD3epsilon mAb is normal, but Con A-stimulated proliferation is greatly diminished.	Tetradecanoylphorbol Acetate	82-85	integrin alpha L	Mus musculus	30-35
8977319-5	1996	In the CD22- murine pro-B cell line, FEMCL, CD22 expression was inducible by treatment with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	92-123	CD22 antigen	Mus musculus	7-11
8977319-5	1996	In the CD22- murine pro-B cell line, FEMCL, CD22 expression was inducible by treatment with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	92-123	CD22 antigen	Mus musculus	44-48
9004163-0	1996	Phorbol myristate acetate-induced hypertrophy of neonatal rat cardiac myocytes is associated with decreased sarcoplasmic reticulum Ca2+ ATPase (SERCA2) gene expression and calcium reuptake.	Tetradecanoylphorbol Acetate	0-25	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	144-150
8948648-7	1996	In the Tst-1/Oct6 gene enhancer, a TPA response element was found in close proximity to the estrogen receptor binding site.	Tetradecanoylphorbol Acetate	35-38	POU domain, class 3, transcription factor 1	Mus musculus	7-12
8948648-7	1996	In the Tst-1/Oct6 gene enhancer, a TPA response element was found in close proximity to the estrogen receptor binding site.	Tetradecanoylphorbol Acetate	35-38	POU domain, class 3, transcription factor 1	Mus musculus	13-17
8969886-8	1996	PMA, on the other hand, induces equally well c-fos, c-jun and c-myc.	Tetradecanoylphorbol Acetate	0-3	FBJ osteosarcoma oncogene	Mus musculus	45-50
8908202-7	1996	As expected, MARCKS is also phosphorylated by phorbol 12-myristate 13 acetate (PMA), a PKC activator, but with a slower onset and more prolonged duration.	Tetradecanoylphorbol Acetate	46-77	myristoylated alanine rich protein kinase C substrate	Bos taurus	13-19
8908202-7	1996	As expected, MARCKS is also phosphorylated by phorbol 12-myristate 13 acetate (PMA), a PKC activator, but with a slower onset and more prolonged duration.	Tetradecanoylphorbol Acetate	79-82	myristoylated alanine rich protein kinase C substrate	Bos taurus	13-19
8958788-12	1996	Phorbol 12-myristate 13-acetate (10 ng/ml) enhanced GM-CSF mRNA and protein levels in all cell types investigated.	Tetradecanoylphorbol Acetate	0-31	colony stimulating factor 2	Homo sapiens	52-58
8938544-8	1996	The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1.	Tetradecanoylphorbol Acetate	109-140	interleukin 1 alpha	Homo sapiens	366-379
8947596-6	1996	However, the T cells of B10 mice produced high levels of IL-2 and IL-4 when stimulated by phorbol myristate acetate (PMA) and Ca2+ ionophore, proving the existence of a functionally intact signal transduction pathway downstream of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	117-120	interleukin 2	Mus musculus	57-61
8947596-6	1996	However, the T cells of B10 mice produced high levels of IL-2 and IL-4 when stimulated by phorbol myristate acetate (PMA) and Ca2+ ionophore, proving the existence of a functionally intact signal transduction pathway downstream of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	117-120	interleukin 4	Mus musculus	66-70
8948021-6	1996	Proper crosslinking of TCR together with CD4, CD8, or LFA-1 inhibits the death, and its inhibitory activity is mimicked by proper combinations of ionomycin, a calcium ionophore, and phorbol myristate acetate (PMA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	182-207	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	23-26
8849450-2	1996	Treatment of human cell lines with soluble monomeric gp120 at 37 degrees C induced an association between the surface CD4-gp120 complex and a 45-kilodalton protein, which can be down-modulated by the phorbol ester phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	214-245	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
8849450-2	1996	Treatment of human cell lines with soluble monomeric gp120 at 37 degrees C induced an association between the surface CD4-gp120 complex and a 45-kilodalton protein, which can be down-modulated by the phorbol ester phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	214-245	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	122-127
8824249-2	1996	Plasminogen activator inhibitor type 2 (PAI-2) mRNA and antigen levels are synergistically induced in HT-1080 fibrosarcoma cells when treated with a combination of tumor necrosis factor (TNF) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	196-227	serpin family B member 2	Homo sapiens	0-38
8824249-2	1996	Plasminogen activator inhibitor type 2 (PAI-2) mRNA and antigen levels are synergistically induced in HT-1080 fibrosarcoma cells when treated with a combination of tumor necrosis factor (TNF) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	196-227	serpin family B member 2	Homo sapiens	40-45
8824249-2	1996	Plasminogen activator inhibitor type 2 (PAI-2) mRNA and antigen levels are synergistically induced in HT-1080 fibrosarcoma cells when treated with a combination of tumor necrosis factor (TNF) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	229-232	serpin family B member 2	Homo sapiens	0-38
8824249-2	1996	Plasminogen activator inhibitor type 2 (PAI-2) mRNA and antigen levels are synergistically induced in HT-1080 fibrosarcoma cells when treated with a combination of tumor necrosis factor (TNF) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	229-232	serpin family B member 2	Homo sapiens	40-45
8874185-1	1996	The level of granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA is fourfold lower in phorbol myristate acetate (PMA) + phytohemagglutinin (PHA)-activated mononuclear cells (MNC) from newborns compared with adults.	Tetradecanoylphorbol Acetate	97-122	colony stimulating factor 2	Homo sapiens	13-61
8874185-1	1996	The level of granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA is fourfold lower in phorbol myristate acetate (PMA) + phytohemagglutinin (PHA)-activated mononuclear cells (MNC) from newborns compared with adults.	Tetradecanoylphorbol Acetate	97-122	colony stimulating factor 2	Homo sapiens	63-69
8874185-1	1996	The level of granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA is fourfold lower in phorbol myristate acetate (PMA) + phytohemagglutinin (PHA)-activated mononuclear cells (MNC) from newborns compared with adults.	Tetradecanoylphorbol Acetate	124-127	colony stimulating factor 2	Homo sapiens	13-61
6331639-0	1984	Induction of mouse brain ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate is independent of TPA receptor concentration.	Tetradecanoylphorbol Acetate	52-88	ornithine decarboxylase, structural 1	Mus musculus	25-48
8874185-1	1996	The level of granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA is fourfold lower in phorbol myristate acetate (PMA) + phytohemagglutinin (PHA)-activated mononuclear cells (MNC) from newborns compared with adults.	Tetradecanoylphorbol Acetate	124-127	colony stimulating factor 2	Homo sapiens	63-69
6331639-3	1984	TPA-dependent induction of ODC activity was maximal on days 5 and 9 postnatally while on day 7, the developmental (endogenous) level of ODC in brain was high and, concurrently, the ability of TPA to induce ODC was reduced.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	27-30
8917435-1	1996	Experiments were designed to clarify the role of c-Jun/c-Fos and of putative phorbol 12-myristate-13-acetate-(PMA)-responsive elements (TREs) in the induction of plasminogen-activator inhibitor 1 (PAI-1) gene transcription in the human hepatoma cell line HepG2 by activators of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	77-108	serpin family E member 1	Homo sapiens	162-195
6331639-3	1984	TPA-dependent induction of ODC activity was maximal on days 5 and 9 postnatally while on day 7, the developmental (endogenous) level of ODC in brain was high and, concurrently, the ability of TPA to induce ODC was reduced.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	136-139
6331639-3	1984	TPA-dependent induction of ODC activity was maximal on days 5 and 9 postnatally while on day 7, the developmental (endogenous) level of ODC in brain was high and, concurrently, the ability of TPA to induce ODC was reduced.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	136-139
6331639-3	1984	TPA-dependent induction of ODC activity was maximal on days 5 and 9 postnatally while on day 7, the developmental (endogenous) level of ODC in brain was high and, concurrently, the ability of TPA to induce ODC was reduced.	Tetradecanoylphorbol Acetate	192-195	ornithine decarboxylase, structural 1	Mus musculus	27-30
6331639-3	1984	TPA-dependent induction of ODC activity was maximal on days 5 and 9 postnatally while on day 7, the developmental (endogenous) level of ODC in brain was high and, concurrently, the ability of TPA to induce ODC was reduced.	Tetradecanoylphorbol Acetate	192-195	ornithine decarboxylase, structural 1	Mus musculus	136-139
6331639-3	1984	TPA-dependent induction of ODC activity was maximal on days 5 and 9 postnatally while on day 7, the developmental (endogenous) level of ODC in brain was high and, concurrently, the ability of TPA to induce ODC was reduced.	Tetradecanoylphorbol Acetate	192-195	ornithine decarboxylase, structural 1	Mus musculus	136-139
8917435-1	1996	Experiments were designed to clarify the role of c-Jun/c-Fos and of putative phorbol 12-myristate-13-acetate-(PMA)-responsive elements (TREs) in the induction of plasminogen-activator inhibitor 1 (PAI-1) gene transcription in the human hepatoma cell line HepG2 by activators of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	110-113	serpin family E member 1	Homo sapiens	162-195
6331639-4	1984	Both TPA-dependent and developmental increases in mouse brain ODC activity were significantly reduced by intracisternal injection of retinoic acid (RA).	Tetradecanoylphorbol Acetate	5-8	ornithine decarboxylase, structural 1	Mus musculus	62-65
8870649-4	1996	c-myc, which was induced strongly in response to PMA treatment, was only marginally up-regulated by bryostatin.	Tetradecanoylphorbol Acetate	49-52	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
6331639-5	1984	The efficacy of TPA in elevating ODC activity at postnatal ages 1-220 days-old was independent of both soluble-and particulate-associated TPA receptor concentration.	Tetradecanoylphorbol Acetate	16-19	ornithine decarboxylase, structural 1	Mus musculus	33-36
6331639-7	1984	Furthermore, the endogenous mechanism of ODC induction is distinct from that of the TPA-dependent increase in ODC enzyme activity.	Tetradecanoylphorbol Acetate	84-87	ornithine decarboxylase, structural 1	Mus musculus	110-113
8870649-6	1996	Finally, an anti-sense oligonucleotide blockade of c-myc inhibited PMA-induced proliferation but not the differentiation of BCLL cells, implicating this nuclear oncogene as an important determinant distinguishing PMA from bryostatin-coupled biological responses and also as a candidate third-messenger effector target for the anti-tumour effects of bryostatin.	Tetradecanoylphorbol Acetate	67-70	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	51-56
6609264-1	1984	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) was used for the induction of in vitro differentiation in primary cultures of chronic lymphocytic leukemia cells to study its effects on B-cell antigens [surface IgG, HLA-DR, and the mouse erythrocyte receptor (MR)] and on T-cell antigens [T65 and Lyt-3 (sheep erythrocyte receptor)] found on these cells.	Tetradecanoylphorbol Acetate	18-54	CD8 antigen, beta chain 1	Mus musculus	309-314
6609264-1	1984	The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) was used for the induction of in vitro differentiation in primary cultures of chronic lymphocytic leukemia cells to study its effects on B-cell antigens [surface IgG, HLA-DR, and the mouse erythrocyte receptor (MR)] and on T-cell antigens [T65 and Lyt-3 (sheep erythrocyte receptor)] found on these cells.	Tetradecanoylphorbol Acetate	56-59	CD8 antigen, beta chain 1	Mus musculus	309-314
9081434-0	1996	[Modulation with phorbol myristate acetate and staurosporine  of interleukin 2- induced proliferation and nonspecific cytotoxicity of rat lymphocytes].	Tetradecanoylphorbol Acetate	17-42	interleukin 2	Rattus norvegicus	65-78
6609264-6	1984	In the T-cell phenotype, TPA increased the expression of T65 and Lyt-3, but it did not induce any B-cell antigens.	Tetradecanoylphorbol Acetate	25-28	CD8 antigen, beta chain 1	Mus musculus	65-70
8813135-8	1996	WAF1/CIP1/p21 expression increased in response to TPA promotion in all HK1-p53 transgenic genotypes regardless of p53 status.	Tetradecanoylphorbol Acetate	50-53	transformation related protein 53, pseudogene	Mus musculus	75-78
6325428-2	1984	Increased phosphorylation of vinculin was noted as early as 10 min following phorbol 12-myristate 13-acetate treatment and was maximal at about 1 h. Maximal increases in phosphorylation were noted at approximately 100 nM phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	77-108	vinculin	Mus musculus	29-37
6325428-2	1984	Increased phosphorylation of vinculin was noted as early as 10 min following phorbol 12-myristate 13-acetate treatment and was maximal at about 1 h. Maximal increases in phosphorylation were noted at approximately 100 nM phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	221-252	vinculin	Mus musculus	29-37
8813135-9	1996	However, in HK1-p53 null genotypes, although TPA-induced, p53-independent WAF1/CIP1/p21 expression was observed, no large increase in expression was associated with the observed paradoxical tumorigenesis block.	Tetradecanoylphorbol Acetate	45-48	transformation related protein 53, pseudogene	Mus musculus	16-19
6322972-4	1984	Both cell lines responded to RA pretreatment with an increase in EGF- and TPA-induced ODC activity, without a concomitant increase in DNA synthesis in either cell line.	Tetradecanoylphorbol Acetate	74-77	ornithine decarboxylase, structural 1	Mus musculus	86-89
8813135-9	1996	However, in HK1-p53 null genotypes, although TPA-induced, p53-independent WAF1/CIP1/p21 expression was observed, no large increase in expression was associated with the observed paradoxical tumorigenesis block.	Tetradecanoylphorbol Acetate	45-48	transformation related protein 53, pseudogene	Mus musculus	58-61
8943722-7	1996	However, IL-1 beta, IL-2 and TNF-alpha mRNA levels of lymph node cells from CD4- mice could be upregulated by phorbol myristate acetate in vitro.	Tetradecanoylphorbol Acetate	110-135	interleukin 2	Mus musculus	20-24
6427052-0	1984	Effects of flavonoids and antioxidants on 12-O-tetradecanoyl-phorbol-13-acetate-caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds.	Tetradecanoylphorbol Acetate	42-79	ornithine decarboxylase, structural 1	Mus musculus	97-120
6427052-1	1984	The effects of flavonoids, antioxidants and related compounds on 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused epidermal ornithine decarboxylase (ODC) induction, DNA synthesis and skin tumor promotion, and on epidermal lipoxygenase activity, were investigated using CD-1 mice.	Tetradecanoylphorbol Acetate	65-101	ornithine decarboxylase, structural 1	Mus musculus	125-148
3102251-3	1987	Stimulation of T lymphocytes with either concanavalin A or the combination of phorbol myristate acetate plus calcium ionophore resulted in increased Pgp-1 expression which was found to be regulated independently of DNA synthesis and interleukin 2 receptor expression.	Tetradecanoylphorbol Acetate	78-103	CD44 antigen	Mus musculus	149-154
9121495-1	1996	Phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) regulation of the GnRH gene was studied in two mouse GnRH neuronal cell lines, Gn11 and NLT.	Tetradecanoylphorbol Acetate	14-51	gonadotropin releasing hormone 1	Mus musculus	76-80
2881817-4	1987	Preincubation of the tissue with the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA, 10(-7) mol/l) translocated PK-C to the membranes, and the majority of this activity was recovered by solubilization.	Tetradecanoylphorbol Acetate	67-103	protein kinase C, gamma	Rattus norvegicus	137-141
2881817-4	1987	Preincubation of the tissue with the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA, 10(-7) mol/l) translocated PK-C to the membranes, and the majority of this activity was recovered by solubilization.	Tetradecanoylphorbol Acetate	105-108	protein kinase C, gamma	Rattus norvegicus	137-141
2881817-11	1987	Involvement of PK-C in Leydig cell function was demonstrated using the TPA, which at 10(-7) mol/l inhibited basal cAMP production by 50% (P less than 0.01) but increased that of testosterone by 2- to 3-fold (P less than 0.01).	Tetradecanoylphorbol Acetate	71-74	protein kinase C, gamma	Rattus norvegicus	15-19
6427052-1	1984	The effects of flavonoids, antioxidants and related compounds on 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused epidermal ornithine decarboxylase (ODC) induction, DNA synthesis and skin tumor promotion, and on epidermal lipoxygenase activity, were investigated using CD-1 mice.	Tetradecanoylphorbol Acetate	65-101	ornithine decarboxylase, structural 1	Mus musculus	150-153
6427052-1	1984	The effects of flavonoids, antioxidants and related compounds on 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused epidermal ornithine decarboxylase (ODC) induction, DNA synthesis and skin tumor promotion, and on epidermal lipoxygenase activity, were investigated using CD-1 mice.	Tetradecanoylphorbol Acetate	103-106	ornithine decarboxylase, structural 1	Mus musculus	150-153
6427052-4	1984	Similarly, morin, fisetin , kaempferol and n-propyl gallate markedly inhibited TPA-caused ODC induction.	Tetradecanoylphorbol Acetate	79-82	ornithine decarboxylase, structural 1	Mus musculus	90-93
6427052-9	1984	Thus, the inhibitory effects of flavonoids and antioxidants on the TPA-caused ODC induction and tumor promotion were roughly parallel with their activities of lipoxygenase inhibition.	Tetradecanoylphorbol Acetate	67-70	ornithine decarboxylase, structural 1	Mus musculus	78-81
6427052-10	1984	These results further support our hypothesis that a lipoxygenase product(s) is involved in the mechanism of TPA-caused ODC induction and tumor promotion.	Tetradecanoylphorbol Acetate	108-111	ornithine decarboxylase, structural 1	Mus musculus	119-122
2430571-2	1986	This TPA (hence probably protein kinase C)-enhanced association of mT with pp60c-src was accompanied by a large increase in the transforming ability of mT as indicated by a much enhanced ability of TPA-treated mT-1 cells producing submaximal levels of mT to proliferate while suspended in semi-solid medium and to form foci on confluent monolayers of normal F111 cells.	Tetradecanoylphorbol Acetate	5-8	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	75-84
9121495-1	1996	Phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) regulation of the GnRH gene was studied in two mouse GnRH neuronal cell lines, Gn11 and NLT.	Tetradecanoylphorbol Acetate	53-56	gonadotropin releasing hormone 1	Mus musculus	76-80
2430571-2	1986	This TPA (hence probably protein kinase C)-enhanced association of mT with pp60c-src was accompanied by a large increase in the transforming ability of mT as indicated by a much enhanced ability of TPA-treated mT-1 cells producing submaximal levels of mT to proliferate while suspended in semi-solid medium and to form foci on confluent monolayers of normal F111 cells.	Tetradecanoylphorbol Acetate	198-201	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	75-84
9121495-1	1996	Phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) regulation of the GnRH gene was studied in two mouse GnRH neuronal cell lines, Gn11 and NLT.	Tetradecanoylphorbol Acetate	53-56	gonadotropin releasing hormone 1	Mus musculus	111-115
9121495-4	1996	In contrast, TPA treatment stimulated expression of a human GnRH-luciferase reporter construct, correlating with the expression of the protoon-cogenes c-fos and c-jun.	Tetradecanoylphorbol Acetate	13-16	gonadotropin releasing hormone 1	Mus musculus	60-64
3770209-1	1986	Two ornithine decarboxylase mRNA species are seen in mouse epidermis in response to the topical application of the phorbol ester tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	145-182	ornithine decarboxylase, structural 1	Mus musculus	4-27
6317450-1	1983	Treatment of human neutrophils with triphenyltin chloride (TPTCl)-inhibited superoxide (O-2) production stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	120-145	immunoglobulin kappa variable 1D-39	Homo sapiens	88-91
6317450-1	1983	Treatment of human neutrophils with triphenyltin chloride (TPTCl)-inhibited superoxide (O-2) production stimulated with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	147-150	immunoglobulin kappa variable 1D-39	Homo sapiens	88-91
8798512-15	1996	Thus, the elevated expression of u-PAR in RKO cells, which constitutively produces this binding site, as well as in phorbol 12-myristate 13-acetate-stimulated GEO cells requires an AP-1 motif located 184 bp upstream of the transcriptional start site.	Tetradecanoylphorbol Acetate	116-147	plasminogen activator, urokinase receptor	Homo sapiens	33-38
6315837-3	1983	When compared to oxidative responses of cells treated with PMA alone, the degree of enhancement by pretreatment with FMLP was 1.85-fold for O-2 generation, 1.73-fold for OH.	Tetradecanoylphorbol Acetate	59-62	immunoglobulin kappa variable 1D-39	Homo sapiens	140-143
6640844-0	1983	The induction of ornithine decarboxylase by phorbol 12-myristate 13-acetate or by serum is inhibited by antioxidants.	Tetradecanoylphorbol Acetate	44-75	ornithine decarboxylase, structural 1	Mus musculus	17-40
3770209-1	1986	Two ornithine decarboxylase mRNA species are seen in mouse epidermis in response to the topical application of the phorbol ester tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	184-187	ornithine decarboxylase, structural 1	Mus musculus	4-27
3769135-3	1986	The time course for the induction of ornithine decarboxylase activity by TPA and the time course for its induction by sn-1,2-didecanoylglycerol were similar; both compounds produced rapid increases in ornithine decarboxylase activity with peak induction occurring 4-6 h after application of the inducing chemical.	Tetradecanoylphorbol Acetate	73-76	ornithine decarboxylase, structural 1	Mus musculus	37-60
3095338-1	1986	12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter, acts similarly to growth factors by selectively increasing the rate of production of the secreted proteins, mitogen regulated protein (MRP) and major excreted protein (MEP) by murine 3T3 cells.	Tetradecanoylphorbol Acetate	0-36	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	177-202
3095338-1	1986	12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter, acts similarly to growth factors by selectively increasing the rate of production of the secreted proteins, mitogen regulated protein (MRP) and major excreted protein (MEP) by murine 3T3 cells.	Tetradecanoylphorbol Acetate	0-36	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	204-207
3095338-1	1986	12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter, acts similarly to growth factors by selectively increasing the rate of production of the secreted proteins, mitogen regulated protein (MRP) and major excreted protein (MEP) by murine 3T3 cells.	Tetradecanoylphorbol Acetate	38-41	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	177-202
3095338-1	1986	12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter, acts similarly to growth factors by selectively increasing the rate of production of the secreted proteins, mitogen regulated protein (MRP) and major excreted protein (MEP) by murine 3T3 cells.	Tetradecanoylphorbol Acetate	38-41	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	204-207
3095338-9	1986	In summary, the ability to TPA and teleocidin to increase the rate of production of MRP and MEP correlated with the ability of these tumor promoters to stimulate DNA synthesis in quiescent 3T3 and TNR-9 cells.	Tetradecanoylphorbol Acetate	27-30	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	84-87
3463364-1	1986	There is a marked increase in the activity of sialic acid lyase (N-acetylneuraminate lyase; EC 4.1.3.3; also known as sialic acid aldolase) in HL-60 cells induced to differentiate into macrophages by the phorbol ester, tetradecanoylphorbol 12-myristate 13 acetate (TPA).	Tetradecanoylphorbol Acetate	265-268	N-acetylneuraminate pyruvate lyase	Homo sapiens	65-90
6640844-3	1983	Therefore, we have studied the effect of antioxidants on the induction of ODC by PMA, medium change only and medium change plus PMA in mouse mammary tumor cells Mm5mt/C1.	Tetradecanoylphorbol Acetate	81-84	ornithine decarboxylase, structural 1	Mus musculus	74-77
6411958-9	1983	CSF-GM was produced in cultures treated singly with 500 ng TPA/ml or with Con A.	Tetradecanoylphorbol Acetate	59-62	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-6
8831575-4	1996	Upon neutrophil challenge with PMA for 10 min the amount of membrane-associated Rab5a was upregulated while the cytosolic content of the protein concomitantly decreased.	Tetradecanoylphorbol Acetate	31-34	RAB5A, member RAS oncogene family	Homo sapiens	80-85
2427243-5	1986	Significantly enhanced levels of Ha-ras RNA were observed in TPA-promoted papillomas as early as 7 weeks after initiation.	Tetradecanoylphorbol Acetate	61-64	Harvey rat sarcoma virus oncogene	Mus musculus	33-39
2427243-6	1986	Only trace amounts of Ha-ras RNA were present in untreated epidermis or epidermis treated with the (+) or (-) enantiomer followed by 2-12 treatments with TPA (pre-papilloma stage).	Tetradecanoylphorbol Acetate	154-157	Harvey rat sarcoma virus oncogene	Mus musculus	22-28
6407752-1	1983	Application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin leads to a manifold induction of ornithine decarboxylase (ODC) activity within 5 hr and an increased accumulation of putrescine.	Tetradecanoylphorbol Acetate	41-77	ornithine decarboxylase, structural 1	Mus musculus	131-154
3768852-1	1986	Ornithine decarboxylase (ODC EC 4.1.1.17) induction in mouse epidermis after single or multiple topical applications of chrysarobin differed from that following topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	222-225	ornithine decarboxylase, structural 1	Mus musculus	0-23
8816913-1	1996	Studies on the link between cellular signalling and cell cycle control at the G2 checkpoint have shown that, in HeLa cells, epidermal growth factor (EGF) and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) rapidly inhibit the G2-M transition by preventing the key component of mitosis-promoting factor (MPF), p34cdc2, from expressing protein kinase activity.	Tetradecanoylphorbol Acetate	176-212	cyclin dependent kinase 1	Homo sapiens	322-329
3093371-2	1986	Induction of IL-2 receptor (IL-2R), IL-2 production and subsequent de novo DNA synthesis in MRL/l mice by the tumour-promoting phorbol ester 12-o-tetradecanoyl phorbol 13-acetate (TPA) and calcium ionophore (A23187) were examined.	Tetradecanoylphorbol Acetate	141-178	interleukin 2 receptor, alpha chain	Mus musculus	13-26
6407752-1	1983	Application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin leads to a manifold induction of ornithine decarboxylase (ODC) activity within 5 hr and an increased accumulation of putrescine.	Tetradecanoylphorbol Acetate	41-77	ornithine decarboxylase, structural 1	Mus musculus	156-159
6407752-1	1983	Application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin leads to a manifold induction of ornithine decarboxylase (ODC) activity within 5 hr and an increased accumulation of putrescine.	Tetradecanoylphorbol Acetate	79-82	ornithine decarboxylase, structural 1	Mus musculus	131-154
6407752-1	1983	Application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin leads to a manifold induction of ornithine decarboxylase (ODC) activity within 5 hr and an increased accumulation of putrescine.	Tetradecanoylphorbol Acetate	79-82	ornithine decarboxylase, structural 1	Mus musculus	156-159
6407752-4	1983	TPA-induced ODC activity and the accumulation of putrescine were almost completely inhibited.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	12-15
8816913-1	1996	Studies on the link between cellular signalling and cell cycle control at the G2 checkpoint have shown that, in HeLa cells, epidermal growth factor (EGF) and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) rapidly inhibit the G2-M transition by preventing the key component of mitosis-promoting factor (MPF), p34cdc2, from expressing protein kinase activity.	Tetradecanoylphorbol Acetate	214-217	epidermal growth factor	Homo sapiens	124-147
8816913-1	1996	Studies on the link between cellular signalling and cell cycle control at the G2 checkpoint have shown that, in HeLa cells, epidermal growth factor (EGF) and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) rapidly inhibit the G2-M transition by preventing the key component of mitosis-promoting factor (MPF), p34cdc2, from expressing protein kinase activity.	Tetradecanoylphorbol Acetate	214-217	epidermal growth factor	Homo sapiens	149-152
3094508-1	1986	12-O-tetradecanoylphorbol-13-acetate (TPA) induced in Balb/c 3T3 cells an earliest prostaglandin biosynthesis and an ornithine decarboxylase activation, this time-relation being more evident if serum was added to incubation medium in low concentration (0.2%).	Tetradecanoylphorbol Acetate	0-36	ornithine decarboxylase, structural 1	Mus musculus	117-140
3094508-1	1986	12-O-tetradecanoylphorbol-13-acetate (TPA) induced in Balb/c 3T3 cells an earliest prostaglandin biosynthesis and an ornithine decarboxylase activation, this time-relation being more evident if serum was added to incubation medium in low concentration (0.2%).	Tetradecanoylphorbol Acetate	38-41	ornithine decarboxylase, structural 1	Mus musculus	117-140
8816913-9	1996	We now show that, concomitant with the prevention of MPF activation, EGF and TPA induced a reduction of the activity of cdc25-C in synchronized cultures.	Tetradecanoylphorbol Acetate	77-80	cell division cycle 25C	Homo sapiens	120-127
3015445-1	1986	In order to investigate the correlation between stimulation of superoxide generation and induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) we have used the macrophage cell line J774.16 and a clone derived from this line that, by contrast with the parental line, is unable to generate superoxides in response to TPA.	Tetradecanoylphorbol Acetate	135-171	ornithine decarboxylase, structural 1	Mus musculus	102-125
6850576-2	1983	Mice maintained on a diet containing 0.75% BHA for 8 days showed a 50% reduction in maximal ODC induction following treatment with TPA when compared to mice fed a control diet.	Tetradecanoylphorbol Acetate	131-134	ornithine decarboxylase, structural 1	Mus musculus	92-95
8816913-10	1996	Furthermore, treatment of mitotic HeLa cells with TPA did not influence the kinase activity of MPF but caused a rapid decrease of the specific enzyme activity of cdc25-C, probably due to dephosphorylation of the enzyme, as indicated by reduced binding of monoclonal MPM-2 antibody specific for phosphoepitopes in M phase.	Tetradecanoylphorbol Acetate	50-53	cell division cycle 25C	Homo sapiens	162-169
8816913-12	1996	The scenario in cells late in G2 that are committed to enter mitosis may be as follows: In those cells where the signalling pathways responding to EGF as well as those responding to TPA are still open, cdc25-C is prevented by dephosphorylation from exceeding the threshold level of activity required to initiate the activation of and the autocatalytic feedback loop with p34cdc2 and to enter mitosis.	Tetradecanoylphorbol Acetate	182-185	cell division cycle 25C	Homo sapiens	202-209
8872603-6	1996	Upon treatment with TPA, H2O2 was produced first, the nuclear proto-oncogenes fos and jun were activated, and then the HO gene was activated.	Tetradecanoylphorbol Acetate	20-23	FBJ osteosarcoma oncogene	Mus musculus	78-81
6850576-3	1983	Topical application of BHA (55 mumol) 30 min prior to TPA treatment (17 nmol) elicited an 80% inhibition of promoter-induced ODC activity.	Tetradecanoylphorbol Acetate	54-57	ornithine decarboxylase, structural 1	Mus musculus	125-128
2426709-5	1986	Promyeloid U937 cells could be induced by 4 beta-phorbol 12-myristate 13-acetate to synthesize and express GPIIb/IIIa-related molecules on their cell surface.	Tetradecanoylphorbol Acetate	42-80	integrin subunit alpha 2b	Homo sapiens	107-112
8872603-7	1996	The extent of transcriptional activation of the fos, jun, and HO genes in M1 cells treated with TPA was reduced by a specific inhibitor of C-kinase and a scavenger of oxygen radicals.	Tetradecanoylphorbol Acetate	96-99	FBJ osteosarcoma oncogene	Mus musculus	48-51
2424975-3	1986	The expression of an antigen reactive to RP-1 on rat peritoneal neutrophils was enhanced by stimulation with phorbol myristate acetate and concanavalin A.	Tetradecanoylphorbol Acetate	109-134	RP1, axonemal microtubule associated	Rattus norvegicus	41-45
6850576-10	1983	Collectively, these results demonstrate an early and direct inhibition of TPA-induced ODC activity by lipophilic phenolic antioxidants and suggest a role for reactive oxygen and/or free radical species in tumor promotion.	Tetradecanoylphorbol Acetate	74-77	ornithine decarboxylase, structural 1	Mus musculus	86-89
8872603-8	1996	When M1 cells were treated with H2O2, essentially the same level of transcription of the HO gene was observed, but the extent of transcriptional activation of the fos and jun genes was about half of the treatment with TPA.	Tetradecanoylphorbol Acetate	218-221	FBJ osteosarcoma oncogene	Mus musculus	163-166
8872603-9	1996	Super-shift assays using the TRE of the HO gene revealed that the Fos and Jun proteins from nuclei of M1 cells treated with TPA bound to the TRE, and same assays using DNA with the NF-kappa B motif also revealed that the active NF-kappa B protein from M1 cells treated with H2O2 or TPA also bound to the corresponding motif.	Tetradecanoylphorbol Acetate	124-127	FBJ osteosarcoma oncogene	Mus musculus	66-69
8819496-7	1996	Pretreatment of P11-5HT1A cells with the phorbol ester, phorbol 12-myristate 13-acetate (PMA), also resulted in desensitization of the 5-HT1A receptor, as indicated by a marked decrease in the potency and intrinsic activity of 8-OH-DPAT.	Tetradecanoylphorbol Acetate	56-87	5-hydroxytryptamine receptor 1A	Homo sapiens	135-150
6600634-1	1983	It has been suggested that 12-0-tetradecanoylphorbol-13-acetate (TPA) may stimulate the proliferation of granulocyte-macrophage (GM) colony-forming cells (CFC) via the GM colony-stimulating factor (CSF) receptor.	Tetradecanoylphorbol Acetate	65-68	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	198-201
6600634-3	1983	The colonies induced by TPA (10(-8)M) were smaller than normally seen with maximal concentrations of GM-CSF, and less than 30% of the GM-CFC formed colonies in the presence of TPA.	Tetradecanoylphorbol Acetate	24-27	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	101-107
6600634-8	1983	The number of colonies formed from the CFC was dependent on the number of accessory cells present, suggesting that the macrophages were induced by TPA to produce CSF.	Tetradecanoylphorbol Acetate	147-150	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	162-165
6600634-9	1983	Although the purified GM-CFC required CSF for proliferation, TPA (10(-8) M) increased (5-10-fold) the sensitivity of the GM-CFC to GM-CSF.	Tetradecanoylphorbol Acetate	61-64	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	131-137
6600634-10	1983	These observations indicate that TPA does not stimulate GM-CFC proliferation directly, but rather by inducing GM-CSF production by accessory cells and by increasing the responsiveness of GM-CFC to GM-CSF.	Tetradecanoylphorbol Acetate	33-36	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	110-116
3099748-1	1986	Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein.	Tetradecanoylphorbol Acetate	83-86	ornithine decarboxylase, structural 1	Mus musculus	112-135
3099748-1	1986	Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein.	Tetradecanoylphorbol Acetate	83-86	ornithine decarboxylase, structural 1	Mus musculus	137-140
3099748-1	1986	Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein.	Tetradecanoylphorbol Acetate	83-86	ornithine decarboxylase, structural 1	Mus musculus	188-191
3099748-1	1986	Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein.	Tetradecanoylphorbol Acetate	83-86	ornithine decarboxylase, structural 1	Mus musculus	188-191
3099748-2	1986	Application of 10 nmol of TPA to mouse skin led to a dramatic increase in soluble epidermal ODC activity which paralleled an increase in amount of enzymically active ODC protein as determined by gel electrophoresis of immunoprecipitated difluoromethyl[3H]ornithine-bound ODC.	Tetradecanoylphorbol Acetate	26-29	ornithine decarboxylase, structural 1	Mus musculus	92-95
3099748-2	1986	Application of 10 nmol of TPA to mouse skin led to a dramatic increase in soluble epidermal ODC activity which paralleled an increase in amount of enzymically active ODC protein as determined by gel electrophoresis of immunoprecipitated difluoromethyl[3H]ornithine-bound ODC.	Tetradecanoylphorbol Acetate	26-29	ornithine decarboxylase, structural 1	Mus musculus	166-169
3099748-2	1986	Application of 10 nmol of TPA to mouse skin led to a dramatic increase in soluble epidermal ODC activity which paralleled an increase in amount of enzymically active ODC protein as determined by gel electrophoresis of immunoprecipitated difluoromethyl[3H]ornithine-bound ODC.	Tetradecanoylphorbol Acetate	26-29	ornithine decarboxylase, structural 1	Mus musculus	166-169
3099748-3	1986	Application of TPA to mouse skin also resulted in an increase in ODC mRNA measured by dot-blot analysis using a radiolabelled cDNA probe.	Tetradecanoylphorbol Acetate	15-18	ornithine decarboxylase, structural 1	Mus musculus	65-68
3099748-4	1986	ODC mRNA induction preceded the increase in ODC activity by TPA.	Tetradecanoylphorbol Acetate	60-63	ornithine decarboxylase, structural 1	Mus musculus	44-47
3099748-5	1986	TPA-increased ODC mRNA displayed a single major band of 2.1 kilobases in size identified by the Northern blotting procedure.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	14-17
6600634-10	1983	These observations indicate that TPA does not stimulate GM-CFC proliferation directly, but rather by inducing GM-CSF production by accessory cells and by increasing the responsiveness of GM-CFC to GM-CSF.	Tetradecanoylphorbol Acetate	33-36	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	197-203
6831394-1	1983	Addition of the tumor promotor 12-O-tetradecanoyl phorbol-13-acetate (TPA) to serum-deprived mouse 3T3 cells resulted in an increase in ornithine decarboxylase activity which is maximal at 3 h and declined thereafter.	Tetradecanoylphorbol Acetate	31-68	ornithine decarboxylase, structural 1	Mus musculus	136-159
6831394-1	1983	Addition of the tumor promotor 12-O-tetradecanoyl phorbol-13-acetate (TPA) to serum-deprived mouse 3T3 cells resulted in an increase in ornithine decarboxylase activity which is maximal at 3 h and declined thereafter.	Tetradecanoylphorbol Acetate	70-73	ornithine decarboxylase, structural 1	Mus musculus	136-159
6833404-0	1983	Glucose uptake and ornithine decarboxylase activity in tetradecanoyl phorbol acetate non-proliferative variants.	Tetradecanoylphorbol Acetate	55-84	ornithine decarboxylase, structural 1	Mus musculus	19-42
6833404-8	1983	Although an elevation of ornithine decarboxylase levels occurred in 3T3-TNR-2 cells treated with TPA, the maximal specific activity in the variant was less than the unstimulated value for 3T3 cells.	Tetradecanoylphorbol Acetate	97-100	ornithine decarboxylase, structural 1	Mus musculus	25-48
6848192-12	1983	Additionally, there is a strain-related difference in sensitivity with regard to ODC-inducing activity of TPA in the livers of C57BL/6 and DBA/2 mice.	Tetradecanoylphorbol Acetate	106-109	ornithine decarboxylase, structural 1	Mus musculus	81-84
6300296-5	1983	An eightfold improvement in the yield of gp340 was obtained when B95-8 cells were cultured in the presence of 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	110-147	deleted in malignant brain tumors 1	Homo sapiens	41-46
6185249-1	1983	Double applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin at intervals of greater than 48 h led to a larger induction of ornithine decarboxylase (ODC) and a smaller increase of DNA and RNA synthesis than did a single application.	Tetradecanoylphorbol Acetate	23-59	ornithine decarboxylase, structural 1	Mus musculus	143-166
6872135-5	1983	Both HD and TPA stimulated maximal ODC activity 3-5 h after application, with epidermal ODC levels returning to basal levels within 12 h. The magnitude of ODC induction after multiple applications of HD was not as great as that observed for TPA.	Tetradecanoylphorbol Acetate	12-15	ornithine decarboxylase, structural 1	Mus musculus	35-38
6872135-6	1983	Single skin applications of TPA and HD also transiently elevated hepatic ODC levels 27- and 7-fold, respectively; however, liver ODC activity did not increase following multiple applications of either chemical.	Tetradecanoylphorbol Acetate	28-31	ornithine decarboxylase, structural 1	Mus musculus	73-76
6319830-2	1983	Phorbol ester (TPA) promotes differentiation of human leukaemic lymphoblasts as assessed by changes in phenotypic surface markers and terminal deoxynucleotidyl transferase (TdT) activity.	Tetradecanoylphorbol Acetate	15-18	DNA nucleotidylexotransferase	Homo sapiens	134-171
6319830-2	1983	Phorbol ester (TPA) promotes differentiation of human leukaemic lymphoblasts as assessed by changes in phenotypic surface markers and terminal deoxynucleotidyl transferase (TdT) activity.	Tetradecanoylphorbol Acetate	15-18	DNA nucleotidylexotransferase	Homo sapiens	173-176
6240487-2	1983	The aim of the first approach was to obtain further evidence for the possible relevance of the induction of ornithine decarboxylase (ODC) activity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin.	Tetradecanoylphorbol Acetate	169-205	ornithine decarboxylase, structural 1	Mus musculus	108-131
6240487-2	1983	The aim of the first approach was to obtain further evidence for the possible relevance of the induction of ornithine decarboxylase (ODC) activity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin.	Tetradecanoylphorbol Acetate	169-205	ornithine decarboxylase, structural 1	Mus musculus	133-136
6240487-2	1983	The aim of the first approach was to obtain further evidence for the possible relevance of the induction of ornithine decarboxylase (ODC) activity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin.	Tetradecanoylphorbol Acetate	207-210	ornithine decarboxylase, structural 1	Mus musculus	108-131
6240487-2	1983	The aim of the first approach was to obtain further evidence for the possible relevance of the induction of ornithine decarboxylase (ODC) activity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin.	Tetradecanoylphorbol Acetate	207-210	ornithine decarboxylase, structural 1	Mus musculus	133-136
6240487-3	1983	The irreversible inhibitor of ODC activity, alpha-difluoromethylornithine, not only prevented ODC activity in a dose-dependent manner following skin application, it also prevented skin tumor promotion by TPA.	Tetradecanoylphorbol Acetate	204-207	ornithine decarboxylase, structural 1	Mus musculus	30-33
6959135-1	1982	Addition of 12-tetradecanoylphorbol 13-acetate (TPA) to cultures of intact Swiss mouse 3T3 fibroblasts induced a dose-dependent increase in ornithine decarboxylase (OrnDCase) activity.	Tetradecanoylphorbol Acetate	12-46	ornithine decarboxylase, structural 1	Mus musculus	140-163
6292251-4	1982	The assay has been used to demonstrate that cell membrane MA is a better source of gp340 for large-scale work than is the Epstein-Barr virus envelope and to measure the increase in expression of gp340 following treatment of cells with 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	235-272	deleted in malignant brain tumors 1	Homo sapiens	83-88
6292251-4	1982	The assay has been used to demonstrate that cell membrane MA is a better source of gp340 for large-scale work than is the Epstein-Barr virus envelope and to measure the increase in expression of gp340 following treatment of cells with 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	235-272	deleted in malignant brain tumors 1	Homo sapiens	195-200
6292251-4	1982	The assay has been used to demonstrate that cell membrane MA is a better source of gp340 for large-scale work than is the Epstein-Barr virus envelope and to measure the increase in expression of gp340 following treatment of cells with 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	274-277	deleted in malignant brain tumors 1	Homo sapiens	195-200
6813857-4	1982	Production of interferon by phorbol myristate acetate-stimulated BFS cell cultures was synergistically increased by the addition of EL4 thymoma cell culture supernatants.	Tetradecanoylphorbol Acetate	28-53	epilepsy 4	Mus musculus	132-135
6279298-1	1982	A series of homologous spin-labeled fatty acid analogs of the type 12-O-FASL (n,m)-phorbol-13-acetate [(n,m)PA] of 12-O-tetradecanoylphorbol-13-acetate (TPA) with variable chain length N of the fatty acid moiety and various positions of the nitroxide group were synthesized.	Tetradecanoylphorbol Acetate	115-151	spindlin 1	Mus musculus	23-27
7116561-8	1982	This is in contrast with the well documented activation of ODC in mouse skin treated with TPA.	Tetradecanoylphorbol Acetate	90-93	ornithine decarboxylase, structural 1	Mus musculus	59-62
7116561-9	1982	Since TPA acts as a promoter in the mouse whereas both croton oil and TPA have no promoting action in the guinea pig, the above result supports the view that ODC activationis related to promotion, and provides a possible explanation for the resistance of this animal species to promotion.	Tetradecanoylphorbol Acetate	6-9	ornithine decarboxylase, structural 1	Mus musculus	158-161
7151243-1	1982	12-O-Tetradecanoylphorbol-13-acetate promotion of skin tumors in mice can be inhibited by topical application of either the phospholipase A2 inhibitor dibromoacetophenone or the cyclooxygenase-lipoxygenase inhibitors 5,8,11,14-eicosatetrayonic acid or 1-phenyl-3-pyrazolidinone.	Tetradecanoylphorbol Acetate	0-36	phospholipase A2, group IB, pancreas	Mus musculus	124-140
6975322-1	1981	A variant line of murine T lymphoma EL4 produces high levels of the lymphokine Interleukin 2 (IL 2) when it is stimulated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	127-152	epilepsy 4	Mus musculus	36-39
6975322-6	1981	The IL 2 produced by injected oocytes from a given preparation of mRNA is about 1% of the amount produced by the EL4 cells stimulated originally with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	150-175	epilepsy 4	Mus musculus	113-116
6975322-8	1981	We conclude that IL 2 is essentially protein in nature, that the protein is coded for by poly A+ mRNA, and that the amount of this mRNA increases significantly after stimulation of the variant EL4 cells with the inducer phorbol myristate acetate.	Tetradecanoylphorbol Acetate	220-245	epilepsy 4	Mus musculus	193-196
7251684-0	1981	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate induces ornithine decarboxylase in proliferating basal cells but not in differentiating cells from mouse epidermis.	Tetradecanoylphorbol Acetate	19-55	ornithine decarboxylase, structural 1	Mus musculus	64-87
7251684-3	1981	This model was utilized to determine which cell type in mouse epidermis responds to the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), by an induction of the enzyme ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	118-154	ornithine decarboxylase, structural 1	Mus musculus	192-215
7251684-3	1981	This model was utilized to determine which cell type in mouse epidermis responds to the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), by an induction of the enzyme ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	118-154	ornithine decarboxylase, structural 1	Mus musculus	217-220
7251684-3	1981	This model was utilized to determine which cell type in mouse epidermis responds to the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), by an induction of the enzyme ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	156-159	ornithine decarboxylase, structural 1	Mus musculus	192-215
7251684-3	1981	This model was utilized to determine which cell type in mouse epidermis responds to the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), by an induction of the enzyme ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	156-159	ornithine decarboxylase, structural 1	Mus musculus	217-220
7251684-4	1981	Previous data had shown that TPA induces ODC in primary mouse epidermal cells only during the first 36 hr after plating in medium containing 1.44 mM Ca2+.	Tetradecanoylphorbol Acetate	29-32	ornithine decarboxylase, structural 1	Mus musculus	41-44
7251684-8	1981	These results strongly suggest that the basal cells of the epidermis constitute the major target cells for the induction of ODC by TPA.	Tetradecanoylphorbol Acetate	131-134	ornithine decarboxylase, structural 1	Mus musculus	124-127
6265062-1	1981	Comparison was made of the ability of the potent tumor promoter phorbol myristate acetate (PMA), as well as less active PMA analogs and non-phorbol ester tumor promoters, to stimulate superoxide anion radical (O-.2) production by human polymorphonuclear leukocytes (PMN).	Tetradecanoylphorbol Acetate	64-89	immunoglobulin kappa variable 1D-39	Homo sapiens	210-214
7248923-1	1981	Addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to a murine epidermal cell line leads to an early induction of the arachidonic acid cascade as measured by the release of [14C]arachidonic acid and [14C]prostaglandin E2 into the medium, to an induction of the ornithine decarboxylase and finally to cell proliferation.	Tetradecanoylphorbol Acetate	30-66	ornithine decarboxylase, structural 1	Mus musculus	283-306
7248923-1	1981	Addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to a murine epidermal cell line leads to an early induction of the arachidonic acid cascade as measured by the release of [14C]arachidonic acid and [14C]prostaglandin E2 into the medium, to an induction of the ornithine decarboxylase and finally to cell proliferation.	Tetradecanoylphorbol Acetate	68-71	ornithine decarboxylase, structural 1	Mus musculus	283-306
7448761-0	1981	Paradoxical effect of anthralin on 12-O-tetradecanoylphorbol-13-acetate-induced mouse epidermal ornithine decarboxylase activity, proliferation, and tumor promotion.	Tetradecanoylphorbol Acetate	35-71	ornithine decarboxylase, structural 1	Mus musculus	96-119
7448775-0	1981	Differential retinoic acid inhibition of ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate and by germicidal ultraviolet light.	Tetradecanoylphorbol Acetate	78-114	ornithine decarboxylase, structural 1	Mus musculus	41-64
7448775-3	1981	It was found that the induction of ODC by TPA is almost completely prevented by 0.1 to 1 microM retinoic acid while the induction by UV is only moderately inhibited.	Tetradecanoylphorbol Acetate	42-45	ornithine decarboxylase, structural 1	Mus musculus	35-38
7448775-7	1981	Other agents known to modulate the induction of ODC by TPA (fluocinolone acetonide, tosyl-L-lysylchloromethane, and local anesthetics) do not act differentially on UV induction.	Tetradecanoylphorbol Acetate	55-58	ornithine decarboxylase, structural 1	Mus musculus	48-51
7448775-8	1981	These agents possibly act at transcription or translation, both of which are required for ODC induction by TPA or UV.	Tetradecanoylphorbol Acetate	107-110	ornithine decarboxylase, structural 1	Mus musculus	90-93
7448775-9	1981	The preferential inhibition by retinoic acid of ODC induction by TPA is interpreted to result from specific interference at a unique and early site of interaction of TPA with the cell.	Tetradecanoylphorbol Acetate	65-68	ornithine decarboxylase, structural 1	Mus musculus	48-51
7448775-9	1981	The preferential inhibition by retinoic acid of ODC induction by TPA is interpreted to result from specific interference at a unique and early site of interaction of TPA with the cell.	Tetradecanoylphorbol Acetate	166-169	ornithine decarboxylase, structural 1	Mus musculus	48-51
6933562-0	1980	Local anesthetics inhibit induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	85-121	ornithine decarboxylase, structural 1	Mus musculus	39-62
6933562-1	1980	The induction of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) activity in mouse epidermal cells in vivo and in vitro occurs rapidly after exposure to the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	189-225	ornithine decarboxylase, structural 1	Mus musculus	17-40
6933562-1	1980	The induction of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) activity in mouse epidermal cells in vivo and in vitro occurs rapidly after exposure to the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	227-230	ornithine decarboxylase, structural 1	Mus musculus	17-40
498078-0	1979	Ornithine decarboxylase activity and DNA synthesis after treatment of cells in culture with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	92-128	ornithine decarboxylase, structural 1	Mus musculus	0-23
498078-1	1979	The ability of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce the enzyme ornithine decarboxylase (ODC) and to stimulate DNA synthesis was studied in four different cell types in vitro.	Tetradecanoylphorbol Acetate	34-70	ornithine decarboxylase, structural 1	Mus musculus	98-121
498078-1	1979	The ability of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce the enzyme ornithine decarboxylase (ODC) and to stimulate DNA synthesis was studied in four different cell types in vitro.	Tetradecanoylphorbol Acetate	34-70	ornithine decarboxylase, structural 1	Mus musculus	123-126
498078-1	1979	The ability of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce the enzyme ornithine decarboxylase (ODC) and to stimulate DNA synthesis was studied in four different cell types in vitro.	Tetradecanoylphorbol Acetate	72-75	ornithine decarboxylase, structural 1	Mus musculus	98-121
498078-1	1979	The ability of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce the enzyme ornithine decarboxylase (ODC) and to stimulate DNA synthesis was studied in four different cell types in vitro.	Tetradecanoylphorbol Acetate	72-75	ornithine decarboxylase, structural 1	Mus musculus	123-126
498078-2	1979	The effects of this agent on each cell type were different: (a) in hamster embryo cells, TPA induced ODC but had no effect on DNA synthesis; (b) TPA induced ODC and stimulated DNA synthesis in BALB/c 3T3 mouse cells; (c) it did not induce ODC in human fibroblasts but did stimulate DNA synthesis; and (d) it induced neither ODC nor DNA synthesis in rat embryo fibroblasts.	Tetradecanoylphorbol Acetate	89-92	ornithine decarboxylase, structural 1	Mus musculus	101-104
498078-2	1979	The effects of this agent on each cell type were different: (a) in hamster embryo cells, TPA induced ODC but had no effect on DNA synthesis; (b) TPA induced ODC and stimulated DNA synthesis in BALB/c 3T3 mouse cells; (c) it did not induce ODC in human fibroblasts but did stimulate DNA synthesis; and (d) it induced neither ODC nor DNA synthesis in rat embryo fibroblasts.	Tetradecanoylphorbol Acetate	145-148	ornithine decarboxylase, structural 1	Mus musculus	157-160
498078-2	1979	The effects of this agent on each cell type were different: (a) in hamster embryo cells, TPA induced ODC but had no effect on DNA synthesis; (b) TPA induced ODC and stimulated DNA synthesis in BALB/c 3T3 mouse cells; (c) it did not induce ODC in human fibroblasts but did stimulate DNA synthesis; and (d) it induced neither ODC nor DNA synthesis in rat embryo fibroblasts.	Tetradecanoylphorbol Acetate	145-148	ornithine decarboxylase, structural 1	Mus musculus	157-160
679197-0	1978	Effects of retinoic acid and juvenile hormone on the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	102-138	ornithine decarboxylase, structural 1	Mus musculus	66-89
626983-0	1978	Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis by vitamin A analogs (retinoids).	Tetradecanoylphorbol Acetate	14-50	ornithine decarboxylase, structural 1	Mus musculus	59-82
954002-0	1976	The effect of colchicine on the induction of ornithine decarboxylase by 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	72-109	ornithine decarboxylase, structural 1	Mus musculus	45-68
954002-1	1976	The induction of mouse epidermal ornithine decarboxylase, 1 of the earliest and largest phenotypic changes following treatment of mouse skin with the tumor-promoting agent, 12-O-tetradecanoyl-phorbol-13-acetate, can be inhibited by prior administration of colchicine.	Tetradecanoylphorbol Acetate	173-210	ornithine decarboxylase, structural 1	Mus musculus	33-56
33352199-10	2021	In ex vivo PMA/ionomycin-stimulated cultures of WC1- gammadelta T cells but not WC1+ produced both IL-17 and IFNgamma.	Tetradecanoylphorbol Acetate	11-14	uncharacterized protein LOC751809	Bos taurus	48-51
33704695-6	2021	Furthermore, the addition of 10-8 M PMA, a well-known PKC activator, mimicked PMCA modulation by LPA.	Tetradecanoylphorbol Acetate	36-39	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	78-82
33760219-0	2021	Bruton"s agammaglobulinemia tyrosine kinase (Btk) regulates TPA-induced breast cancer cell invasion via PLCgamma2/PKCbeta/NF-kappaB/AP-1-dependent matrix metalloproteinase-9 activation.	Tetradecanoylphorbol Acetate	60-63	Bruton tyrosine kinase	Homo sapiens	0-43
33760219-0	2021	Bruton"s agammaglobulinemia tyrosine kinase (Btk) regulates TPA-induced breast cancer cell invasion via PLCgamma2/PKCbeta/NF-kappaB/AP-1-dependent matrix metalloproteinase-9 activation.	Tetradecanoylphorbol Acetate	60-63	Bruton tyrosine kinase	Homo sapiens	45-48
33760219-0	2021	Bruton"s agammaglobulinemia tyrosine kinase (Btk) regulates TPA-induced breast cancer cell invasion via PLCgamma2/PKCbeta/NF-kappaB/AP-1-dependent matrix metalloproteinase-9 activation.	Tetradecanoylphorbol Acetate	60-63	matrix metallopeptidase 9	Homo sapiens	147-173
33760219-5	2021	In this study, the anti-metastatic activity of BTK inhibitors was examined in MCF-7 cells focusing on MMP-9 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated MCF-7 cells.	Tetradecanoylphorbol Acetate	122-158	matrix metallopeptidase 9	Homo sapiens	102-107
33760219-5	2021	In this study, the anti-metastatic activity of BTK inhibitors was examined in MCF-7 cells focusing on MMP-9 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated MCF-7 cells.	Tetradecanoylphorbol Acetate	160-163	Bruton tyrosine kinase	Homo sapiens	47-50
33760219-5	2021	In this study, the anti-metastatic activity of BTK inhibitors was examined in MCF-7 cells focusing on MMP-9 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated MCF-7 cells.	Tetradecanoylphorbol Acetate	160-163	matrix metallopeptidase 9	Homo sapiens	102-107
33923123-0	2021	Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-Associated NOD2 Mutations.	Tetradecanoylphorbol Acetate	71-96	platelet derived growth factor subunit B	Homo sapiens	50-56
33443102-7	2021	Finally, we found that silencing of PKCalpha, but not PKCdelta, inhibits phorbol-12-myristate-13-acetate (PMA)-induced cytoplasmic enrichment of KRIT1, suggesting a major role for PKCalpha in regulating KRIT1 nucleocytoplasmic shuttling.	Tetradecanoylphorbol Acetate	73-104	KRIT1 ankyrin repeat containing	Homo sapiens	145-150
33443102-7	2021	Finally, we found that silencing of PKCalpha, but not PKCdelta, inhibits phorbol-12-myristate-13-acetate (PMA)-induced cytoplasmic enrichment of KRIT1, suggesting a major role for PKCalpha in regulating KRIT1 nucleocytoplasmic shuttling.	Tetradecanoylphorbol Acetate	73-104	KRIT1 ankyrin repeat containing	Homo sapiens	203-208
33443102-7	2021	Finally, we found that silencing of PKCalpha, but not PKCdelta, inhibits phorbol-12-myristate-13-acetate (PMA)-induced cytoplasmic enrichment of KRIT1, suggesting a major role for PKCalpha in regulating KRIT1 nucleocytoplasmic shuttling.	Tetradecanoylphorbol Acetate	106-109	KRIT1 ankyrin repeat containing	Homo sapiens	145-150
33443102-7	2021	Finally, we found that silencing of PKCalpha, but not PKCdelta, inhibits phorbol-12-myristate-13-acetate (PMA)-induced cytoplasmic enrichment of KRIT1, suggesting a major role for PKCalpha in regulating KRIT1 nucleocytoplasmic shuttling.	Tetradecanoylphorbol Acetate	106-109	KRIT1 ankyrin repeat containing	Homo sapiens	203-208
33310310-5	2021	RESULTS: The results provide evidence that topical treatment with HPSB significantly inhibits TPA-induced epidermal hyperplasia and leukocyte infiltration through the down-regulation of cyclooxygenase-2 (COX-2), matrix metalloprotein-9 (MMP-9), and ornithine decarboxylase (ODC) protein expression in mouse skin.	Tetradecanoylphorbol Acetate	94-97	ornithine decarboxylase, structural 1	Mus musculus	249-272
33310310-5	2021	RESULTS: The results provide evidence that topical treatment with HPSB significantly inhibits TPA-induced epidermal hyperplasia and leukocyte infiltration through the down-regulation of cyclooxygenase-2 (COX-2), matrix metalloprotein-9 (MMP-9), and ornithine decarboxylase (ODC) protein expression in mouse skin.	Tetradecanoylphorbol Acetate	94-97	ornithine decarboxylase, structural 1	Mus musculus	274-277
32956670-9	2020	The ability of Pyk2 and Src inhibitors to restore Cx43 function in the presence of PMA was also observed in NRVMs.	Tetradecanoylphorbol Acetate	83-86	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	24-27
33182021-11	2020	NEAT1 expression in Jurkat cells was induced by PMA/ionomycin stimulation upon activation of the TCR-p38 pathway.	Tetradecanoylphorbol Acetate	48-51	nuclear paraspeckle assembly transcript 1	Homo sapiens	0-5
33182021-13	2020	Knocking down NEAT1 expression with an ASO suppressed the expression of CXCL8 and TNF-alpha in PMA/ionomycin-stimulated Jurkat cells.	Tetradecanoylphorbol Acetate	95-98	nuclear paraspeckle assembly transcript 1	Homo sapiens	14-19
33182021-15	2020	Furthermore, we also detected the expression profile of Jurkat cells stimulated by PMA/ionomycin when NEAT1 was silenced or not, in order to produce an overview of NEAT1-regulated genes.	Tetradecanoylphorbol Acetate	83-86	nuclear paraspeckle assembly transcript 1	Homo sapiens	102-107
33182021-15	2020	Furthermore, we also detected the expression profile of Jurkat cells stimulated by PMA/ionomycin when NEAT1 was silenced or not, in order to produce an overview of NEAT1-regulated genes.	Tetradecanoylphorbol Acetate	83-86	nuclear paraspeckle assembly transcript 1	Homo sapiens	164-169
33229509-10	2020	To complete the analysis of the CXCL10/CXCL11/CXCR3 axis, we activated miR-34a-5p transfected CD4+ and CD8+ T cells by PMA/Ionomycin and found reduced levels of endogenous CXCR3 and CXCR3 on the cell surface.	Tetradecanoylphorbol Acetate	119-122	C-X-C motif chemokine ligand 10	Homo sapiens	32-38
3011239-5	1986	The authors have therefore also investigated the changes in enzyme pattern of B-CLL after incubation with TPA B-CLL cells are characterized by low levels of ADA, PNP, and 5"-NT, but TPA caused a marked increase in PNP activity (P less than 0.001, t test for paired samples), a pattern similar to HCL.	Tetradecanoylphorbol Acetate	106-109	adenosine deaminase	Homo sapiens	157-160
3487457-11	1986	This phenomenon was found to correlate functionally with increased proliferative response of the T cells, in presence of phorbol myristate acetate, to anti-Ly-6 antibodies cross-linked on their surface.	Tetradecanoylphorbol Acetate	121-146	lymphocyte antigen 6 complex	Mus musculus	156-160
3087287-6	1986	Epidermal ODC activity increased by TPA appears to be the result of an increase in both the amount of ODC protein and the level of hybridizable ODC messenger.	Tetradecanoylphorbol Acetate	36-39	ornithine decarboxylase, structural 1	Mus musculus	102-105
3087287-6	1986	Epidermal ODC activity increased by TPA appears to be the result of an increase in both the amount of ODC protein and the level of hybridizable ODC messenger.	Tetradecanoylphorbol Acetate	36-39	ornithine decarboxylase, structural 1	Mus musculus	102-105
3085964-9	1986	The retinoid and DFMO preclude TPA-increased ornithine decarboxylase (ODC) activity and the accumulation of putrescine by differential effects on ODC, an enzyme associated with skin tumor promotion by TPA.	Tetradecanoylphorbol Acetate	31-34	ornithine decarboxylase, structural 1	Mus musculus	45-68
3085964-9	1986	The retinoid and DFMO preclude TPA-increased ornithine decarboxylase (ODC) activity and the accumulation of putrescine by differential effects on ODC, an enzyme associated with skin tumor promotion by TPA.	Tetradecanoylphorbol Acetate	31-34	ornithine decarboxylase, structural 1	Mus musculus	70-73
3085964-9	1986	The retinoid and DFMO preclude TPA-increased ornithine decarboxylase (ODC) activity and the accumulation of putrescine by differential effects on ODC, an enzyme associated with skin tumor promotion by TPA.	Tetradecanoylphorbol Acetate	201-204	ornithine decarboxylase, structural 1	Mus musculus	146-149
3708757-7	1986	Anti-promotion properties were assessed by measuring the effects of apigenin, robinetin and indole-3-carbinol on induction of ornithine decarboxylase activity (ODC) in mouse epidermis by 17 nmol 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	195-232	ornithine decarboxylase, structural 1	Mus musculus	126-149
3708757-7	1986	Anti-promotion properties were assessed by measuring the effects of apigenin, robinetin and indole-3-carbinol on induction of ornithine decarboxylase activity (ODC) in mouse epidermis by 17 nmol 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	195-232	ornithine decarboxylase, structural 1	Mus musculus	160-163
3708757-7	1986	Anti-promotion properties were assessed by measuring the effects of apigenin, robinetin and indole-3-carbinol on induction of ornithine decarboxylase activity (ODC) in mouse epidermis by 17 nmol 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	234-237	ornithine decarboxylase, structural 1	Mus musculus	160-163
3708757-11	1986	Inhibition by 30-90% of TPA-induced ODC was observed at 6 h after TPA in mice pretreated with 12.5-100 mumol apigenin.	Tetradecanoylphorbol Acetate	24-27	ornithine decarboxylase, structural 1	Mus musculus	36-39
3708757-11	1986	Inhibition by 30-90% of TPA-induced ODC was observed at 6 h after TPA in mice pretreated with 12.5-100 mumol apigenin.	Tetradecanoylphorbol Acetate	66-69	ornithine decarboxylase, structural 1	Mus musculus	36-39
3708757-12	1986	Pretreatment with 37.5 or 50 mumol indole-3-carbinol or 0.5, 12.5 or 25 mumol robinetin resulted in elevated induction of epidermal ODC by TPA at 6 h after TPA.	Tetradecanoylphorbol Acetate	139-142	ornithine decarboxylase, structural 1	Mus musculus	132-135
3708757-12	1986	Pretreatment with 37.5 or 50 mumol indole-3-carbinol or 0.5, 12.5 or 25 mumol robinetin resulted in elevated induction of epidermal ODC by TPA at 6 h after TPA.	Tetradecanoylphorbol Acetate	156-159	ornithine decarboxylase, structural 1	Mus musculus	132-135
3708757-13	1986	However, treatment with 50 or 100 mumol robinetin diminished ODC induction at 6 h after TPA.	Tetradecanoylphorbol Acetate	88-91	ornithine decarboxylase, structural 1	Mus musculus	61-64
3486215-4	1986	The combination of phytohemagglutinin (PHA) and 4 beta-phorbol 12-myristate 13-acetate (PMA) stimulated DNA synthesis by accessory cell (AC)-depleted T cells cultured at high density, but the use of low density cultures indicated that intact AC were absolutely necessary for PHA-stimulated T cell DNA synthesis even in the presence of PMA, interleukin 1 (IL 1), or interleukin 2 (IL 2).	Tetradecanoylphorbol Acetate	48-86	interleukin-2	Cavia porcellus	380-384
3486215-4	1986	The combination of phytohemagglutinin (PHA) and 4 beta-phorbol 12-myristate 13-acetate (PMA) stimulated DNA synthesis by accessory cell (AC)-depleted T cells cultured at high density, but the use of low density cultures indicated that intact AC were absolutely necessary for PHA-stimulated T cell DNA synthesis even in the presence of PMA, interleukin 1 (IL 1), or interleukin 2 (IL 2).	Tetradecanoylphorbol Acetate	88-91	interleukin-2	Cavia porcellus	380-384
2937805-8	1986	Activation of poly-ADP-ribose polymerase was also observed in peripheral lymphocytes incubated in the presence of phorbol myristate acetate-stimulated polymorphonuclear neutrophils.	Tetradecanoylphorbol Acetate	114-139	poly (ADP-ribose) polymerase family, member 1	Mus musculus	14-40
3081453-2	1986	When direct induction of ODC by TPA was blocked by also applying indomethacin, maximum ODC activity occurred only when PGE was applied simultaneously with TPA 4 1/2 hr before killing of the mice.	Tetradecanoylphorbol Acetate	32-35	ornithine decarboxylase, structural 1	Mus musculus	25-28
3081453-2	1986	When direct induction of ODC by TPA was blocked by also applying indomethacin, maximum ODC activity occurred only when PGE was applied simultaneously with TPA 4 1/2 hr before killing of the mice.	Tetradecanoylphorbol Acetate	32-35	ornithine decarboxylase, structural 1	Mus musculus	87-90
3081453-2	1986	When direct induction of ODC by TPA was blocked by also applying indomethacin, maximum ODC activity occurred only when PGE was applied simultaneously with TPA 4 1/2 hr before killing of the mice.	Tetradecanoylphorbol Acetate	155-158	ornithine decarboxylase, structural 1	Mus musculus	25-28
3081453-2	1986	When direct induction of ODC by TPA was blocked by also applying indomethacin, maximum ODC activity occurred only when PGE was applied simultaneously with TPA 4 1/2 hr before killing of the mice.	Tetradecanoylphorbol Acetate	155-158	ornithine decarboxylase, structural 1	Mus musculus	87-90
3081453-3	1986	If either TPA or PGE was applied at other times, ODC activity decreased substantially.	Tetradecanoylphorbol Acetate	10-13	ornithine decarboxylase, structural 1	Mus musculus	49-52
3081453-4	1986	Induction of ODC by mezerein was blocked by indomethacin but restored by PGE, as was observed with TPA, but induction by ethyl phenylpropiolate was not affected by indomethacin or PGE.	Tetradecanoylphorbol Acetate	99-102	ornithine decarboxylase, structural 1	Mus musculus	13-16
3081453-7	1986	Inhibition by topical retinoic acid of ODC induction by TPA was partially overcome in a dose-response fashion by PGE.	Tetradecanoylphorbol Acetate	56-59	ornithine decarboxylase, structural 1	Mus musculus	39-42
3513761-0	1986	Enhancement of glucagon secretion from isolated rat islets of Langerhans by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	76-107	glucagon	Rattus norvegicus	15-23
3513761-1	1986	The phorbol ester 4 beta-phorbol 12-myristate 13-acetate (PMA), at concentrations of 0.1 microM and above, stimulated secretion of glucagon and of insulin from isolated rat islets of Langerhans incubated in the presence of 5.5 mM-glucose.	Tetradecanoylphorbol Acetate	20-56	glucagon	Rattus norvegicus	131-139
3513761-1	1986	The phorbol ester 4 beta-phorbol 12-myristate 13-acetate (PMA), at concentrations of 0.1 microM and above, stimulated secretion of glucagon and of insulin from isolated rat islets of Langerhans incubated in the presence of 5.5 mM-glucose.	Tetradecanoylphorbol Acetate	58-61	glucagon	Rattus norvegicus	131-139
2417740-4	1986	A phorbol acetate (12-O-tetradecanoylphorbol 13-acetate) caused a twofold enhancement in tPA yield but the most significant results were obtained with 5-azacytidine.	Tetradecanoylphorbol Acetate	19-55	chromosome 20 open reading frame 181	Homo sapiens	89-92
3080438-3	1986	Removal of vinculin from adhesion plaques following exposure of cells to PDGF was temperature dependent, occurred in many fibroblast cell lines, and could be mimicked by 12-tetradecanoyl phorbol-13-acetate (TPA; 5-125 nM) or melittin (0.35 microM).	Tetradecanoylphorbol Acetate	170-205	vinculin	Mus musculus	11-19
3080438-3	1986	Removal of vinculin from adhesion plaques following exposure of cells to PDGF was temperature dependent, occurred in many fibroblast cell lines, and could be mimicked by 12-tetradecanoyl phorbol-13-acetate (TPA; 5-125 nM) or melittin (0.35 microM).	Tetradecanoylphorbol Acetate	207-210	vinculin	Mus musculus	11-19
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Tetradecanoylphorbol Acetate	58-61	complement C3	Homo sapiens	65-68
3079908-3	1986	We propose a stereochemical model in which the oxygens in TPA at C-3, C-4, C-9, and C-20 (O-3, O-4, O-9, and O-20) correspond to the O-11, N-13, N-1, and O-24 positions in teleocidin and the O-27, O-3, O-11, and O-30 oxygens in aplysiatoxin, respectively.	Tetradecanoylphorbol Acetate	58-61	complement C9	Homo sapiens	75-78
3002353-4	1985	These results are consistent with a role for p21 in signal transduction related to the effects of TPA.	Tetradecanoylphorbol Acetate	98-101	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	45-48
3876342-0	1985	Role of phorbol ester receptors in the 12-0-tetradecanoyl-phorbol-13-acetate (TPA)-induced down-regulation of colony-stimulating factor (CSF-1) binding to murine peritoneal exudate macrophages.	Tetradecanoylphorbol Acetate	78-81	colony stimulating factor 1 (macrophage)	Mus musculus	137-142
3876342-1	1985	Treatment of murine peritoneal exudate macrophages (PEM) by tumor-promoting phorbol esters (TPA) results in a rapid loss of binding activity to radioactive-labeled colony-stimulating factor ([125I]-CSF-1) on the cell surface.	Tetradecanoylphorbol Acetate	92-95	colony stimulating factor 1 (macrophage)	Mus musculus	198-203
3876342-2	1985	The inhibitory effect of TPA on PEM is transient; treated cells recover full [125I]-CSF-1 binding activity in less than 6 hr at 37 degrees C either in the presence or after the removal of added TPA.	Tetradecanoylphorbol Acetate	25-28	colony stimulating factor 1 (macrophage)	Mus musculus	84-89
3876342-14	1985	This study provides evidence that the loss of CSF-1-receptors induced by TPA treatment requires the presence of phorbol ester receptors and proceeds presumably via a co-internalization of both CSF-1 and phorbol ester receptors; the refractoriness to TPA is thereby induced by a transient loss of available phorbol ester receptors.	Tetradecanoylphorbol Acetate	73-76	colony stimulating factor 1 (macrophage)	Mus musculus	46-51
3876342-14	1985	This study provides evidence that the loss of CSF-1-receptors induced by TPA treatment requires the presence of phorbol ester receptors and proceeds presumably via a co-internalization of both CSF-1 and phorbol ester receptors; the refractoriness to TPA is thereby induced by a transient loss of available phorbol ester receptors.	Tetradecanoylphorbol Acetate	73-76	colony stimulating factor 1 (macrophage)	Mus musculus	193-198
3876342-14	1985	This study provides evidence that the loss of CSF-1-receptors induced by TPA treatment requires the presence of phorbol ester receptors and proceeds presumably via a co-internalization of both CSF-1 and phorbol ester receptors; the refractoriness to TPA is thereby induced by a transient loss of available phorbol ester receptors.	Tetradecanoylphorbol Acetate	250-253	colony stimulating factor 1 (macrophage)	Mus musculus	46-51
2992824-1	1985	Previously it was shown that lipophilic analogs of a free-radical scavenger, 2(3)-tert-butyl-4-hydroxyanisole (BHA), inhibit ornithine decarboxylase (ODC) activity which is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse epidermis.	Tetradecanoylphorbol Acetate	184-220	ornithine decarboxylase, structural 1	Mus musculus	125-148
2992824-1	1985	Previously it was shown that lipophilic analogs of a free-radical scavenger, 2(3)-tert-butyl-4-hydroxyanisole (BHA), inhibit ornithine decarboxylase (ODC) activity which is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse epidermis.	Tetradecanoylphorbol Acetate	184-220	ornithine decarboxylase, structural 1	Mus musculus	150-153
2992824-1	1985	Previously it was shown that lipophilic analogs of a free-radical scavenger, 2(3)-tert-butyl-4-hydroxyanisole (BHA), inhibit ornithine decarboxylase (ODC) activity which is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse epidermis.	Tetradecanoylphorbol Acetate	222-225	ornithine decarboxylase, structural 1	Mus musculus	125-148
2992824-1	1985	Previously it was shown that lipophilic analogs of a free-radical scavenger, 2(3)-tert-butyl-4-hydroxyanisole (BHA), inhibit ornithine decarboxylase (ODC) activity which is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse epidermis.	Tetradecanoylphorbol Acetate	222-225	ornithine decarboxylase, structural 1	Mus musculus	150-153
2992824-6	1985	The inhibitory activities of these analogs for lipid peroxidation were related to both their lipophilic and antioxidant properties and corresponded favorably with their inhibitory activities for TPA-induced ODC activities in mouse epidermis.	Tetradecanoylphorbol Acetate	195-198	ornithine decarboxylase, structural 1	Mus musculus	207-210
2992824-8	1985	These results imply that lipophilic BHA analogs inhibit TPA-induced ODC activity by scavenging free radicals other than O-2.	Tetradecanoylphorbol Acetate	56-59	ornithine decarboxylase, structural 1	Mus musculus	68-71
3925027-4	1985	The stimulation of phospholipase A2 action was observed in the order of A23187 greater than FBS greater than TPA.	Tetradecanoylphorbol Acetate	109-112	phospholipase A2, group IB, pancreas	Mus musculus	19-35
2987226-7	1985	Since stimulation of granulocytes by phorbol myristate acetate, FMLP, or C5a results in exocytosis and/or endocytosis, then the role of these processes in regulating stimulated O-2 production by controlling the content of plasma membrane redox enzymes is questionable.	Tetradecanoylphorbol Acetate	37-62	immunoglobulin kappa variable 1D-39	Homo sapiens	177-180
3922966-8	1985	Presumably, calcium ionophore unmasked the synthesis of leukotriene C4 from phorbol myristate acetate-released and exogenous arachidonate by elevating intracellular calcium levels enough for 5-lipoxygenase activation.	Tetradecanoylphorbol Acetate	76-101	arachidonate 5-lipoxygenase	Mus musculus	191-205
2987422-3	1985	O-2 release was quantified by evaluating superoxide dismutase-inhibitable reduction of cytochrome c after stimulation of monocytes with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	136-161	immunoglobulin kappa variable 1D-39	Homo sapiens	0-3
2997989-1	1985	Superinfection of Raji cells with Epstein-Barr virus (EBV) or chemical induction of HR-1 cells with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) results in the induction of a deoxyuridine triphosphate nucleotidohydrolase (dUTPase) which is not observed in mock-treated cells or TPA-treated EBV genome-negative BJAB cells.	Tetradecanoylphorbol Acetate	139-142	Deoxyuridine triphosphatase	Drosophila melanogaster	221-228
3158313-3	1985	Other agents which either stimulate PK C directly (1-oleoyl-2-acetyl-sn-glycerol and 12-O-tetradecanoyl phorbol-13-acetate) or elevate cellular diglyceride levels (phospholipase C) also promoted a redistribution of the enzyme from cytosol to membrane.	Tetradecanoylphorbol Acetate	85-122	protein kinase C, gamma	Rattus norvegicus	36-40
3158316-5	1985	These results suggest that the activation of protein kinase C is an initial and essential event in the process of ornithine decarboxylase induction caused by 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	158-195	ornithine decarboxylase, structural 1	Mus musculus	114-137
3156132-1	1985	The relative abilities of insulin and the phorbol ester tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) to lead to the phosphorylation of ribosomal protein S6 in vivo were compared in a Reuber H35 hepatoma cell line shown previously to be highly responsive to these agents.	Tetradecanoylphorbol Acetate	71-108	ribosomal protein S6	Rattus norvegicus	149-169
3156132-1	1985	The relative abilities of insulin and the phorbol ester tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) to lead to the phosphorylation of ribosomal protein S6 in vivo were compared in a Reuber H35 hepatoma cell line shown previously to be highly responsive to these agents.	Tetradecanoylphorbol Acetate	110-113	ribosomal protein S6	Rattus norvegicus	149-169
2578899-4	1985	TPA application at day 7 evokes, however, (i) a hyperplastic reaction followed by a massive "psoriasis-like" hyperkeratosis, (ii) an increase of ornithine decarboxylase activity and (iii) a restoration of the neonatal keratin polypeptide pattern.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	145-168
3939686-10	1985	Treatment of HL60 cells with 12-0 tetra decanoylphorbol-13-acetate (TPA), which promotes macrophage-like differentiation, also induced c-fos with a time course similar to that observed in mitogen-treated fibroblasts.	Tetradecanoylphorbol Acetate	68-71	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	135-140
6092699-1	1984	cDNA libraries from EL-4 cells treated with 12-O-tetradecanoyl phorbol-13-acetate (TPA) were screened for TPA-inducible sequences by differential hybridization.	Tetradecanoylphorbol Acetate	44-81	epilepsy 4	Mus musculus	20-24
6089211-1	1984	Supernatants from phorbol 12-myristate 13-acetate-activated cultures of the mouse EL4 thymoma, or of several mouse T-cell hybridomas stimulated either by their specific antigen or by concanavalin A, induced primary splenic B cells to proliferate and differentiate to antibody-secreting cells.	Tetradecanoylphorbol Acetate	18-49	epilepsy 4	Mus musculus	82-85
6746662-8	1984	Membranes of resting and phorbol myristate acetate-stimulated cytoplasts contain equal amounts of cytochrome b (4 pmol/milliunit of alkaline phosphatase) and also equal amounts of noncovalently bound FAD (2 pmol/milliunit of alkaline phosphatase).	Tetradecanoylphorbol Acetate	25-50	mitochondrially encoded cytochrome b	Homo sapiens	98-110
6368713-1	1984	Culture fluids from a phorbol myristate acetate-stimulated EL-4 thymoma cell line were previously found to activate mouse macrophages to become nonspecifically tumoricidal.	Tetradecanoylphorbol Acetate	22-47	epilepsy 4	Mus musculus	59-63
6085623-1	1984	Treatment of resident murine peritoneal macrophages with 12-O-tetradecanoyl phorbol-13-acetate (TPA) rapidly converted the cells to tumour cytostatic and cytolytic effector cells, as determined by growth inhibition or lysis of T-lymphoma cells (Eb, EL4) in vitro.	Tetradecanoylphorbol Acetate	57-94	epilepsy 4	Mus musculus	249-252
6085623-1	1984	Treatment of resident murine peritoneal macrophages with 12-O-tetradecanoyl phorbol-13-acetate (TPA) rapidly converted the cells to tumour cytostatic and cytolytic effector cells, as determined by growth inhibition or lysis of T-lymphoma cells (Eb, EL4) in vitro.	Tetradecanoylphorbol Acetate	96-99	epilepsy 4	Mus musculus	249-252
6315223-7	1983	The magnitude of vesical ODC induction correlated well with the ability of a series of phorbol esters to promote mouse skin tumor formation (TPA greater than phorbol didecanoate greater than phorbol dibenzoate, and phorbol diacetate or phorbol did not induce bladder ODC activity).	Tetradecanoylphorbol Acetate	141-144	ornithine decarboxylase, structural 1	Mus musculus	25-28
6315223-9	1983	Increased ODC activity by TPA was the result of an increased amount of ODC protein localized mostly (greater than 60%) in urinary bladder mucosa.	Tetradecanoylphorbol Acetate	26-29	ornithine decarboxylase, structural 1	Mus musculus	10-13
6315223-9	1983	Increased ODC activity by TPA was the result of an increased amount of ODC protein localized mostly (greater than 60%) in urinary bladder mucosa.	Tetradecanoylphorbol Acetate	26-29	ornithine decarboxylase, structural 1	Mus musculus	71-74
6315223-14	1983	Since TPA binds specifically to urinary bladder epithelium, and the induction of ODC activity is one of the properties of tumor promoters, one may conclude that TPA may promote urinary bladder carcinogenesis.	Tetradecanoylphorbol Acetate	161-164	ornithine decarboxylase, structural 1	Mus musculus	81-84
6644098-0	1983	Effects of amino acid treatments on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis in vivo and in vitro.	Tetradecanoylphorbol Acetate	36-72	ornithine decarboxylase, structural 1	Mus musculus	81-104
6644098-4	1983	Arginine and its analog, canavanine, inhibited to the same degree TPA-induced ornithine decarboxylase activity, and potentiated to the same extent the inhibitory effects of glutamic acid, asparagine, and glycine on this enzyme.	Tetradecanoylphorbol Acetate	66-69	ornithine decarboxylase, structural 1	Mus musculus	78-101
6315213-0	1983	Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis by sweetening agents and related compounds.	Tetradecanoylphorbol Acetate	14-50	ornithine decarboxylase, structural 1	Mus musculus	59-82
6315213-1	1983	The effects of naturally occurring sweetening agents, which inhibited the induction of Epstein-Barr virus-associated early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), and related compounds on the induction of ornithine decarboxylase (ODC) by TPA is examined.	Tetradecanoylphorbol Acetate	151-187	ornithine decarboxylase, structural 1	Mus musculus	237-260
6315213-2	1983	Application of glycyrrhetinic acid or steviol to mouse skin 1 h before TPA treatment showed a remarkable decrease in TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	71-74	ornithine decarboxylase, structural 1	Mus musculus	129-132
6315213-2	1983	Application of glycyrrhetinic acid or steviol to mouse skin 1 h before TPA treatment showed a remarkable decrease in TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	117-120	ornithine decarboxylase, structural 1	Mus musculus	129-132
6315213-3	1983	Post-treatment with glycyrrhetinic acid or steviol 1 h after application of TPA also resulted in a considerable depression in the induction of ODC activity.	Tetradecanoylphorbol Acetate	76-79	ornithine decarboxylase, structural 1	Mus musculus	143-146
6315213-5	1983	These results suggest that glycyrrhetinic acid and steviol interfere with the process of induction of epidermal ODC by TPA treatment of mouse skin.	Tetradecanoylphorbol Acetate	119-122	ornithine decarboxylase, structural 1	Mus musculus	112-115
6413085-2	1983	TPA (20 nmol/mouse)-induced epidermal ornithine decarboxylase (ODC) activity was also inhibited by quercetin (10-30 mumol/mouse), but it failed to inhibit the stimulation of epidermal DNA synthesis by TPA.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	38-61
6413085-2	1983	TPA (20 nmol/mouse)-induced epidermal ornithine decarboxylase (ODC) activity was also inhibited by quercetin (10-30 mumol/mouse), but it failed to inhibit the stimulation of epidermal DNA synthesis by TPA.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	63-66
6413085-2	1983	TPA (20 nmol/mouse)-induced epidermal ornithine decarboxylase (ODC) activity was also inhibited by quercetin (10-30 mumol/mouse), but it failed to inhibit the stimulation of epidermal DNA synthesis by TPA.	Tetradecanoylphorbol Acetate	201-204	ornithine decarboxylase, structural 1	Mus musculus	63-66
6413085-5	1983	These results suggest that the inhibition of lipoxygenase by quercetin is one of the major actions of the above agent to inhibit tumor promotion and TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	149-152	ornithine decarboxylase, structural 1	Mus musculus	161-164
6616764-2	1983	In CFLP mice, which responded to carcinogen with development of lung-adenomas, a single topical application of TPA to hairless mouse skin increased ornithine decarboxylase activity in the lung.	Tetradecanoylphorbol Acetate	111-114	ornithine decarboxylase, structural 1	Mus musculus	148-171
6311564-3	1983	The method consists in the evaluation of the stimulation of superoxide anion (O-2) production (as superoxide dismutase-sensitive cytochrome c reduction) by leukocytes in whole blood challenged with (a) phagocytosable particles (opsonized zymosan); (b) particles that become phagocytosable by virtue of the opsonizing capacity of the plasma of blood samples (zymosan); and (c) a soluble agent such as phorbol myristate acetate.	Tetradecanoylphorbol Acetate	400-425	immunoglobulin kappa variable 1D-39	Homo sapiens	78-81
6306017-4	1983	Biologically active TPA (12-O-tetradecanoyl phorbol-13-acetate) inhibits the binding of 125I-CSF-1 to its receptor on PEM.	Tetradecanoylphorbol Acetate	20-23	colony stimulating factor 1 (macrophage)	Mus musculus	93-98
6306017-4	1983	Biologically active TPA (12-O-tetradecanoyl phorbol-13-acetate) inhibits the binding of 125I-CSF-1 to its receptor on PEM.	Tetradecanoylphorbol Acetate	25-62	colony stimulating factor 1 (macrophage)	Mus musculus	93-98
6306017-8	1983	Treated cells recover their 125I-CSF-1-binding activity whether TPA is later removed or not.	Tetradecanoylphorbol Acetate	64-67	colony stimulating factor 1 (macrophage)	Mus musculus	33-38
6304119-1	1983	The tumor-promoting phorbol diester, 12-O-tetradecanoylphorbol-13-acetate (TPA) was found to act both independently of and synergistically with the mononuclear phagocyte specific colony stimulating factor (CSF-1) to stimulate the formation of macrophage colonies in cultures of mouse bone marrow cells.	Tetradecanoylphorbol Acetate	37-73	colony stimulating factor 1 (macrophage)	Mus musculus	206-211
6304119-1	1983	The tumor-promoting phorbol diester, 12-O-tetradecanoylphorbol-13-acetate (TPA) was found to act both independently of and synergistically with the mononuclear phagocyte specific colony stimulating factor (CSF-1) to stimulate the formation of macrophage colonies in cultures of mouse bone marrow cells.	Tetradecanoylphorbol Acetate	75-78	colony stimulating factor 1 (macrophage)	Mus musculus	206-211
6304119-4	1983	However, TPA-stimulated colony formation was suboptimal and delayed in serum-free cultures that could support optimal colony formation in the presence of CSF-1.	Tetradecanoylphorbol Acetate	9-12	colony stimulating factor 1 (macrophage)	Mus musculus	154-159
6304119-7	1983	Thus, TPA is able to mimic CSF-1 in its effects on CSF-1 responsive cells in some aspects (the spectrum of target cells, the morphology of resulting colonies, and the ability to down-regulate the CSF-1 receptor) but it is not able to mimic CSF-1 in other ways (TPA alone cannot stimulate the full CSF-1 response, TPA does not stimulate the most primitive CSF-1 responsive cells, and TPA does not bind to the CSF-1 receptor).	Tetradecanoylphorbol Acetate	6-9	colony stimulating factor 1 (macrophage)	Mus musculus	27-32
6304119-7	1983	Thus, TPA is able to mimic CSF-1 in its effects on CSF-1 responsive cells in some aspects (the spectrum of target cells, the morphology of resulting colonies, and the ability to down-regulate the CSF-1 receptor) but it is not able to mimic CSF-1 in other ways (TPA alone cannot stimulate the full CSF-1 response, TPA does not stimulate the most primitive CSF-1 responsive cells, and TPA does not bind to the CSF-1 receptor).	Tetradecanoylphorbol Acetate	6-9	colony stimulating factor 1 (macrophage)	Mus musculus	51-56
6304119-7	1983	Thus, TPA is able to mimic CSF-1 in its effects on CSF-1 responsive cells in some aspects (the spectrum of target cells, the morphology of resulting colonies, and the ability to down-regulate the CSF-1 receptor) but it is not able to mimic CSF-1 in other ways (TPA alone cannot stimulate the full CSF-1 response, TPA does not stimulate the most primitive CSF-1 responsive cells, and TPA does not bind to the CSF-1 receptor).	Tetradecanoylphorbol Acetate	6-9	colony stimulating factor 1 (macrophage)	Mus musculus	51-56
6304119-7	1983	Thus, TPA is able to mimic CSF-1 in its effects on CSF-1 responsive cells in some aspects (the spectrum of target cells, the morphology of resulting colonies, and the ability to down-regulate the CSF-1 receptor) but it is not able to mimic CSF-1 in other ways (TPA alone cannot stimulate the full CSF-1 response, TPA does not stimulate the most primitive CSF-1 responsive cells, and TPA does not bind to the CSF-1 receptor).	Tetradecanoylphorbol Acetate	6-9	colony stimulating factor 1 (macrophage)	Mus musculus	51-56
6304119-7	1983	Thus, TPA is able to mimic CSF-1 in its effects on CSF-1 responsive cells in some aspects (the spectrum of target cells, the morphology of resulting colonies, and the ability to down-regulate the CSF-1 receptor) but it is not able to mimic CSF-1 in other ways (TPA alone cannot stimulate the full CSF-1 response, TPA does not stimulate the most primitive CSF-1 responsive cells, and TPA does not bind to the CSF-1 receptor).	Tetradecanoylphorbol Acetate	6-9	colony stimulating factor 1 (macrophage)	Mus musculus	51-56
6840848-2	1983	LK produced by incubating spleen cells from immunized A/J and LAF mice with concanavalin A stimulated a response by thio MACs to phorbol-12-myristate-13-acetate (PMA)-induced chemiluminescence and activated these cells to inhibit intracellular Chlamydia psittaci replication.	Tetradecanoylphorbol Acetate	129-160	myristoylated alanine rich protein kinase C substrate	Mus musculus	121-125
6404265-1	1983	NADPH-dependent O2- generating oxidoreductase activity recovered from cell lysates of phorbol myristate acetate-stimulated human neutrophils exhibits dependence on Ca+2 and Mg+2 for full expression of its catalytic activity.	Tetradecanoylphorbol Acetate	86-111	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
6404265-1	1983	NADPH-dependent O2- generating oxidoreductase activity recovered from cell lysates of phorbol myristate acetate-stimulated human neutrophils exhibits dependence on Ca+2 and Mg+2 for full expression of its catalytic activity.	Tetradecanoylphorbol Acetate	86-111	thioredoxin reductase 1	Homo sapiens	31-45
6848192-4	1983	dose of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 micrograms/kg) enhanced the activity of ODC about 70-fold within 12 hr in C57BL/6 mice and 18-fold within 24 hr in DBA/2 mice without affecting AHH activity markedly.	Tetradecanoylphorbol Acetate	27-63	ornithine decarboxylase, structural 1	Mus musculus	114-117
6848192-4	1983	dose of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 micrograms/kg) enhanced the activity of ODC about 70-fold within 12 hr in C57BL/6 mice and 18-fold within 24 hr in DBA/2 mice without affecting AHH activity markedly.	Tetradecanoylphorbol Acetate	65-68	ornithine decarboxylase, structural 1	Mus musculus	114-117
6848192-5	1983	4-O-Methyl-12-O-tetradecanoylphorbol-13-acetate (100 micrograms/kg) raised ODC activity to about 25% of the TPA-treated value in C57BL/6 mice; in DBA/2 mice, TPA and 4-O-methyl-12-O-tetradecanoylphorbol-13-acetate induced ODC activity to roughly the same level.	Tetradecanoylphorbol Acetate	108-111	ornithine decarboxylase, structural 1	Mus musculus	75-78
6848192-7	1983	The inducing effect of TPA on ODC activity was potentiated by a simultaneous administration of MC to C57BL/6 mice; combined TPA and TCDD to DBA/2 mice exerted an additive effect on hepatic ODC activity.	Tetradecanoylphorbol Acetate	23-26	ornithine decarboxylase, structural 1	Mus musculus	30-33
6848192-7	1983	The inducing effect of TPA on ODC activity was potentiated by a simultaneous administration of MC to C57BL/6 mice; combined TPA and TCDD to DBA/2 mice exerted an additive effect on hepatic ODC activity.	Tetradecanoylphorbol Acetate	23-26	ornithine decarboxylase, structural 1	Mus musculus	189-192
6848192-7	1983	The inducing effect of TPA on ODC activity was potentiated by a simultaneous administration of MC to C57BL/6 mice; combined TPA and TCDD to DBA/2 mice exerted an additive effect on hepatic ODC activity.	Tetradecanoylphorbol Acetate	124-127	ornithine decarboxylase, structural 1	Mus musculus	189-192
6848192-9	1983	effectively inhibited the induction of ODC activity elicited by TPA, MC, or TCDD either alone or in various combinations but did not interfere with AHH induction.	Tetradecanoylphorbol Acetate	64-67	ornithine decarboxylase, structural 1	Mus musculus	39-42
6848192-10	1983	These data indicate that different regulatory factors are involved in the ODC induction process elicited by TPA and polycyclic aromatic compounds and that MC and TCDD may induce ODC activity by different mechanisms.	Tetradecanoylphorbol Acetate	108-111	ornithine decarboxylase, structural 1	Mus musculus	74-77
6185249-1	1983	Double applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin at intervals of greater than 48 h led to a larger induction of ornithine decarboxylase (ODC) and a smaller increase of DNA and RNA synthesis than did a single application.	Tetradecanoylphorbol Acetate	23-59	ornithine decarboxylase, structural 1	Mus musculus	168-171
6185249-1	1983	Double applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin at intervals of greater than 48 h led to a larger induction of ornithine decarboxylase (ODC) and a smaller increase of DNA and RNA synthesis than did a single application.	Tetradecanoylphorbol Acetate	61-64	ornithine decarboxylase, structural 1	Mus musculus	143-166
6185249-1	1983	Double applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin at intervals of greater than 48 h led to a larger induction of ornithine decarboxylase (ODC) and a smaller increase of DNA and RNA synthesis than did a single application.	Tetradecanoylphorbol Acetate	61-64	ornithine decarboxylase, structural 1	Mus musculus	168-171
6982943-1	1982	Supernatant culture fluids from a phorbol myristate acetate (PMA) stimulated variant of the murine EL-4 thymoma cell line activated inflammatory macrophages for nonspecific tumoricidal activity in vitro; active supernatants fluids were not directly toxic to tumor target cells in the absence of macrophages.	Tetradecanoylphorbol Acetate	34-59	epilepsy 4	Mus musculus	99-103
6982943-1	1982	Supernatant culture fluids from a phorbol myristate acetate (PMA) stimulated variant of the murine EL-4 thymoma cell line activated inflammatory macrophages for nonspecific tumoricidal activity in vitro; active supernatants fluids were not directly toxic to tumor target cells in the absence of macrophages.	Tetradecanoylphorbol Acetate	61-64	epilepsy 4	Mus musculus	99-103
6805948-0	1982	Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by phospholipase A2 inhibitors and lipoxygenase inhibitor.	Tetradecanoylphorbol Acetate	14-50	ornithine decarboxylase, structural 1	Mus musculus	69-92
6805948-0	1982	Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by phospholipase A2 inhibitors and lipoxygenase inhibitor.	Tetradecanoylphorbol Acetate	14-50	phospholipase A2, group IB, pancreas	Mus musculus	105-121
33719253-6	2020	Results: The levels of c-fos protein and mRNA expressions were up-regulated during PMA-induced polarization of THP-1 monocytes.	Tetradecanoylphorbol Acetate	83-86	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	23-28
31303127-6	2020	This was associated with inhibition of cell proliferation in LycT + DMBA/TPA group as observed by the decrease in epidermal morphometric parameters and mRNA and protein expression of proliferating cell nuclear antigen when compared to DMBA/TPA group (p <= 0.05).	Tetradecanoylphorbol Acetate	73-76	proliferating cell nuclear antigen	Mus musculus	183-217
32673666-4	2020	Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages, followed by induction to osteoclasts using macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL).	Tetradecanoylphorbol Acetate	0-31	TNF superfamily member 11	Homo sapiens	236-241
32673666-4	2020	Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages, followed by induction to osteoclasts using macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL).	Tetradecanoylphorbol Acetate	33-36	TNF superfamily member 11	Homo sapiens	196-234
32673666-4	2020	Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages, followed by induction to osteoclasts using macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL).	Tetradecanoylphorbol Acetate	33-36	TNF superfamily member 11	Homo sapiens	236-241
32913271-4	2020	In the patients with T2D (DM), multifunctionality of circulating CD8 + PD-1 + T cells stimulated with PMA/ionomycin as well as with HLA-A*24:02 CMV peptide was dampened, while metformin recovered multifunctionality.	Tetradecanoylphorbol Acetate	102-105	CD8a molecule	Homo sapiens	65-68
32339486-10	2020	The SGK1 inhibitor GSK650394 stimulated GPRC5A basal levels at low doses and inhibit its TPA-induced expression at concentrations >=10 muM.	Tetradecanoylphorbol Acetate	89-92	serum/glucocorticoid regulated kinase 1	Homo sapiens	4-8
32339486-13	2020	PKA and SGK1 kinases are also involved in its TPA-induced upregulation.	Tetradecanoylphorbol Acetate	46-49	serum/glucocorticoid regulated kinase 1	Homo sapiens	8-12
32447451-5	2020	RESULTS: Stimulation of cells by PMA or LPS (without Actovegin ) significantly increased the secretion of IL-1beta, IL-6, IL-10 and TNF-alpha from PBMCs, compared to controls.	Tetradecanoylphorbol Acetate	33-36	interleukin 10	Homo sapiens	122-127
6805948-1	1982	Application of 12-O-tetradecanoylphorbol-13-acetate (TPA; 20 nmol/mouse), a tumor-promoting agent, to mouse skin results in an induction of epidermal ornithine decarboxylase (ODC; EC 4.1.1.17).	Tetradecanoylphorbol Acetate	15-51	ornithine decarboxylase, structural 1	Mus musculus	150-173
6805948-1	1982	Application of 12-O-tetradecanoylphorbol-13-acetate (TPA; 20 nmol/mouse), a tumor-promoting agent, to mouse skin results in an induction of epidermal ornithine decarboxylase (ODC; EC 4.1.1.17).	Tetradecanoylphorbol Acetate	15-51	ornithine decarboxylase, structural 1	Mus musculus	175-178
6805948-1	1982	Application of 12-O-tetradecanoylphorbol-13-acetate (TPA; 20 nmol/mouse), a tumor-promoting agent, to mouse skin results in an induction of epidermal ornithine decarboxylase (ODC; EC 4.1.1.17).	Tetradecanoylphorbol Acetate	53-56	ornithine decarboxylase, structural 1	Mus musculus	150-173
6805948-1	1982	Application of 12-O-tetradecanoylphorbol-13-acetate (TPA; 20 nmol/mouse), a tumor-promoting agent, to mouse skin results in an induction of epidermal ornithine decarboxylase (ODC; EC 4.1.1.17).	Tetradecanoylphorbol Acetate	53-56	ornithine decarboxylase, structural 1	Mus musculus	175-178
8819496-7	1996	Pretreatment of P11-5HT1A cells with the phorbol ester, phorbol 12-myristate 13-acetate (PMA), also resulted in desensitization of the 5-HT1A receptor, as indicated by a marked decrease in the potency and intrinsic activity of 8-OH-DPAT.	Tetradecanoylphorbol Acetate	89-92	5-hydroxytryptamine receptor 1A	Homo sapiens	135-150
6805948-2	1982	Induction of ODC by TPA was inhibited by treatment of skin with indomethacin (1.12 mumol/mouse), a cyclooxygenase inhibitor, and the ODC activity suppressed by indomethacin was completely restored by concurrent application of prostaglandin E2 (PGE2) (140 nmol/mouse) as described first by Verma et al.	Tetradecanoylphorbol Acetate	20-23	ornithine decarboxylase, structural 1	Mus musculus	13-16
6805948-2	1982	Induction of ODC by TPA was inhibited by treatment of skin with indomethacin (1.12 mumol/mouse), a cyclooxygenase inhibitor, and the ODC activity suppressed by indomethacin was completely restored by concurrent application of prostaglandin E2 (PGE2) (140 nmol/mouse) as described first by Verma et al.	Tetradecanoylphorbol Acetate	20-23	ornithine decarboxylase, structural 1	Mus musculus	133-136
32505192-6	2020	METHODS: Herein, we used rat brain astrocytes (RBA) to demonstrate the signaling mechanisms of phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression by zymographic, RT-PCR, subcellular isolation, Western blot, ROS detection, and promoter reporter analyses.	Tetradecanoylphorbol Acetate	95-126	matrix metallopeptidase 9	Rattus norvegicus	141-146
32505192-6	2020	METHODS: Herein, we used rat brain astrocytes (RBA) to demonstrate the signaling mechanisms of phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression by zymographic, RT-PCR, subcellular isolation, Western blot, ROS detection, and promoter reporter analyses.	Tetradecanoylphorbol Acetate	128-131	matrix metallopeptidase 9	Rattus norvegicus	141-146
32505192-7	2020	Then, we evaluate the effects of rottlerin on PMA-induced MMP-9 expression in RBA and its influencing mechanism.	Tetradecanoylphorbol Acetate	46-49	matrix metallopeptidase 9	Rattus norvegicus	58-63
32505192-9	2020	Subsequently, PMA induced MMP-9 expression via PKCdelta-mediated reactive oxygen species (ROS) generation, extracellular signal-regulated kinase 1/2 (ERK1/2) activation, and then induced c-Fos/AP-1 signaling pathway.	Tetradecanoylphorbol Acetate	14-17	matrix metallopeptidase 9	Rattus norvegicus	26-31
7116338-0	1982	Dissociation of 12-O-tetradecanoylphorbol-13-acetate and 3-methylcholanthrene-induced induction in ornithine decarboxylase and aryl hydrocarbon hydroxylase activities in C57BL/6 mouse dermal fibroblasts in culture.	Tetradecanoylphorbol Acetate	16-52	ornithine decarboxylase, structural 1	Mus musculus	99-122
8806873-3	1996	This in vitro system displays many of the functional and metabolic properties of a differentiated epidermis and can be induced to specifically release IL-1 alpha in response to a mixture of lipopolysaccharide and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	213-238	interleukin 1 alpha	Homo sapiens	151-161
7068980-1	1982	The tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) causes a dose-dependent induction (up to 300-fold) of ornithine decarboxylase activity in the epidermis of intact mice within 5 hours after the application to the skin of from 1 to 10 nmoles of the ester in 0.2 ml of acetone.	Tetradecanoylphorbol Acetate	35-71	ornithine decarboxylase, structural 1	Mus musculus	132-155
32505192-9	2020	Subsequently, PMA induced MMP-9 expression via PKCdelta-mediated reactive oxygen species (ROS) generation, extracellular signal-regulated kinase 1/2 (ERK1/2) activation, and then induced c-Fos/AP-1 signaling pathway.	Tetradecanoylphorbol Acetate	14-17	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	187-192
7068980-1	1982	The tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) causes a dose-dependent induction (up to 300-fold) of ornithine decarboxylase activity in the epidermis of intact mice within 5 hours after the application to the skin of from 1 to 10 nmoles of the ester in 0.2 ml of acetone.	Tetradecanoylphorbol Acetate	73-76	ornithine decarboxylase, structural 1	Mus musculus	132-155
8702672-4	1996	Secretion of stored SP-B was stimulated by forskolin/12-O-tetradecanoylphorbol-13-acetate and intracellular SP-B was localized to secretory granules by immunoelectron microscopy.	Tetradecanoylphorbol Acetate	53-89	surfactant associated protein B	Mus musculus	20-24
7035564-5	1982	TPA-treated cells also underwent a concomitant decrease in the expression of TdT when analyzed enzymatically or by immunofluorescence.	Tetradecanoylphorbol Acetate	0-3	DNA nucleotidylexotransferase	Homo sapiens	77-80
32317318-5	2020	Here, we found that bone marrow-derived macrophages (BMDM) from myeloid cell lineage-selective CD147-null mice had significantly reduced Ehrlichia-induced or EtpE-C-induced blockade of ROS generation in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	215-240	basigin	Mus musculus	95-100
8759733-4	1996	The shift of Lck following direct PKC activation by 12-O-tetradecanoyl phorbol 13-acetate, which bypasses early receptor-triggered biochemical events, is insensitive to forskolin.	Tetradecanoylphorbol Acetate	52-89	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tetradecanoylphorbol Acetate	36-39	colony stimulating factor 3	Homo sapiens	50-55
31893611-0	2020	Methyl linderone suppresses TPA-stimulated IL-8 and MMP-9 expression via the ERK/STAT3 pathway in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	28-31	matrix metallopeptidase 9	Homo sapiens	52-57
31893611-6	2020	Moreover, it inhibited two metastasis-related factors, matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8), at the mRNA and protein expression levels, in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	162-165	matrix metallopeptidase 9	Homo sapiens	55-81
7051778-0	1982	Disappearance of nuclear TdT in RPMI-8402 following TPA treatment.	Tetradecanoylphorbol Acetate	52-55	DNA nucleotidylexotransferase	Homo sapiens	25-28
31893611-6	2020	Moreover, it inhibited two metastasis-related factors, matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8), at the mRNA and protein expression levels, in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	162-165	matrix metallopeptidase 9	Homo sapiens	83-88
8753812-4	1996	The synergistic interaction between PMA and RA on G-CSF production appeared to be mediated primarily through production of interleukin-1 beta (IL-1 beta) since neutralization of IL-1 beta activity inhibited about 80% of G-CSF production.	Tetradecanoylphorbol Acetate	36-39	colony stimulating factor 3	Homo sapiens	220-225
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	colony stimulating factor 3	Homo sapiens	83-88
8702641-6	1996	In addition, forskolin and a PKA agonist, Sp-8-CTP-cAMP-S, increased PKC activity, and direct stimulation of PKC with phorbol 12-myristate 13-acetate increased PLC-gamma protein and activity, effects that were blocked by calphostin C. We suggest that the D1A-mediated stimulation of PLC occurs as a result of PKA activation.	Tetradecanoylphorbol Acetate	118-149	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	309-312
31932898-8	2020	The resultant sustained [Ca2+]i increase is additive to submaximal, but not maximal carbachol-induced [Ca2+]i. Synergistic mucin secretion was mimicked by VIP plus either phorbol 12-myristate 13-acetate or 0.01 muM thapsigargin, and blocked by the PKC inhibitor, Go6976.	Tetradecanoylphorbol Acetate	171-202	solute carrier family 13 member 2	Rattus norvegicus	123-128
7122574-3	1982	The data presented here indicate that PMA treatment induces in myotubes increased synthesis of a 31.000 Mr polypeptide (31 K) within 4 hr of treatment, while the inhibition of the synthesis of contractile proteins, such as myosin and actin, occurs only after 8 hr of treatment.	Tetradecanoylphorbol Acetate	38-41	myosin, heavy chain 10, non-muscle	Gallus gallus	223-229
8702564-2	1996	125I-Heregulin binding to NIH 3T3 cells overexpressing the ErbB-4 receptor is rapidly decreased by 12-O-tetradecanoylphorbol-13-acetate (TPA) pretreatment.	Tetradecanoylphorbol Acetate	99-135	erb-b2 receptor tyrosine kinase 4	Mus musculus	59-65
6970773-7	1981	However, when 12-O-tetradecanoylphorbol 13-acetate (TPA), a promoter of T cell colony growth shown in other systems to inhibit metabolic cooperation, was added, a striking decrease in frequency of colonies with both G-6-PD types was found.	Tetradecanoylphorbol Acetate	14-50	glucose-6-phosphate dehydrogenase	Homo sapiens	216-222
6970773-7	1981	However, when 12-O-tetradecanoylphorbol 13-acetate (TPA), a promoter of T cell colony growth shown in other systems to inhibit metabolic cooperation, was added, a striking decrease in frequency of colonies with both G-6-PD types was found.	Tetradecanoylphorbol Acetate	52-55	glucose-6-phosphate dehydrogenase	Homo sapiens	216-222
30794104-1	2020	BACKGROUND: Malignant profile computed tomography perfusion (CTP) lesions are associated with poor outcomes after administration of intravenous tissue-plasminogen activator (IV-tPA) for ischemic stroke.	Tetradecanoylphorbol Acetate	177-180	chromosome 20 open reading frame 181	Homo sapiens	144-172
8702564-2	1996	125I-Heregulin binding to NIH 3T3 cells overexpressing the ErbB-4 receptor is rapidly decreased by 12-O-tetradecanoylphorbol-13-acetate (TPA) pretreatment.	Tetradecanoylphorbol Acetate	137-140	erb-b2 receptor tyrosine kinase 4	Mus musculus	59-65
7448785-4	1981	12-O-Tetradecanoylphorbol-13-acetate, a potent promoter in mouse skin carcinogenesis, induced a 39-fold increase in ornithine decarboxylase activity, the best response among the various substances tested.	Tetradecanoylphorbol Acetate	0-36	ornithine decarboxylase, structural 1	Mus musculus	116-139
8702564-3	1996	Immunologic analysis demonstrates that TPA treatment of cells induces the proteolytic cleavage of ErbB-4, producing an 80-kDa cytoplasmic domain fragment, which contains a low level of phosphotyrosine, and a 120-kDa ectodomain fragment, which is released into the extracellular medium.	Tetradecanoylphorbol Acetate	39-42	erb-b2 receptor tyrosine kinase 4	Mus musculus	98-104
8702564-4	1996	Cleavage of ErbB-4 was also enhanced by other protein kinase C activators, i.e. platelet-derived growth factor, ionomycin, and synthetic diacylglycerol, while protein kinase C inhibition or down-regulation suppressed the TPA stimulation of ErbB-4 degradation.	Tetradecanoylphorbol Acetate	221-224	erb-b2 receptor tyrosine kinase 4	Mus musculus	12-18
8709153-1	1996	We have studied the effect of gelsolin, a Ca-dependent actin-binding protein, on the microsecond rotational dynamics of actin filaments, using time-resolved phosphorescence (TPA) and absorption anisotropy (TAA) of erythrosin iodoacetamide attached to Cys374 on actin.	Tetradecanoylphorbol Acetate	174-177	gelsolin	Homo sapiens	30-38
6116315-0	1981	Inhibition by epidermal extracts of the 12-O-tetradecanoylphorbol-13-acetate induced peak of ornithine decarboxylase activity in the mouse epidermis.	Tetradecanoylphorbol Acetate	40-76	ornithine decarboxylase, structural 1	Mus musculus	93-116
6116315-2	1981	4.1.117) (ODC) activity following a single topical application of 17 nmoles of 12-O-tetradecanoylphorbol-13-acetate (TPA) on hairless mouse skin was established.	Tetradecanoylphorbol Acetate	79-115	ornithine decarboxylase, structural 1	Mus musculus	10-13
6116315-2	1981	4.1.117) (ODC) activity following a single topical application of 17 nmoles of 12-O-tetradecanoylphorbol-13-acetate (TPA) on hairless mouse skin was established.	Tetradecanoylphorbol Acetate	117-120	ornithine decarboxylase, structural 1	Mus musculus	10-13
6116315-7	1981	Following the administration of epidermal extracts, the inhibition of the TPA-induced ODC-response correlated positively with the presence of epidermal G2-chalone activity (determined by a stathmokinetic method) whereas myocardial, skeletal muscle, or heat-inactivated epidermal extracts with no epidermal G2-chalone activity, had no effect on TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	74-77	ornithine decarboxylase, structural 1	Mus musculus	86-89
33268675-0	2020	The effects of Phorbol 12-myristate 13-acetate concentration on the expression of miR-155 and miR-125b and their macrophage function-related genes in the U937 cell line.	Tetradecanoylphorbol Acetate	15-46	microRNA 155	Homo sapiens	82-89
6116315-7	1981	Following the administration of epidermal extracts, the inhibition of the TPA-induced ODC-response correlated positively with the presence of epidermal G2-chalone activity (determined by a stathmokinetic method) whereas myocardial, skeletal muscle, or heat-inactivated epidermal extracts with no epidermal G2-chalone activity, had no effect on TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	74-77	ornithine decarboxylase, structural 1	Mus musculus	356-359
8871052-6	1996	In three out of nine clones tested, the stimulation with anti-CD2/CD28/phorbol myristate acetate (PMA) induced a shift of the IFN-gamma/IL-4 ratio towards a Th2-type cytokine profile.	Tetradecanoylphorbol Acetate	71-96	CD2 molecule	Homo sapiens	62-65
31727941-7	2019	Following phorbol myristate acetate stimulation of the cultured PBMNCs, flow cytometry revealed a decrease in intracellular IL-10 storage in the main cell populations of the PBMNCs cultured from MMD patients relative to those cultured from controls.	Tetradecanoylphorbol Acetate	10-35	interleukin 10	Homo sapiens	124-129
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	175-206	CD8a molecule	Homo sapiens	35-38
8871052-6	1996	In three out of nine clones tested, the stimulation with anti-CD2/CD28/phorbol myristate acetate (PMA) induced a shift of the IFN-gamma/IL-4 ratio towards a Th2-type cytokine profile.	Tetradecanoylphorbol Acetate	98-101	CD2 molecule	Homo sapiens	62-65
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	175-206	CD8a molecule	Homo sapiens	265-268
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	175-206	CD8a molecule	Homo sapiens	265-268
7471050-1	1980	The induction of epidermal ornithine decarboxylase (EC 4.1.1.17) (ODC) following topical application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mice can be inhibited by topical application of putrescine, the product of the enzyme.	Tetradecanoylphorbol Acetate	130-166	ornithine decarboxylase, structural 1	Mus musculus	27-50
7471050-1	1980	The induction of epidermal ornithine decarboxylase (EC 4.1.1.17) (ODC) following topical application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mice can be inhibited by topical application of putrescine, the product of the enzyme.	Tetradecanoylphorbol Acetate	130-166	ornithine decarboxylase, structural 1	Mus musculus	66-69
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	208-211	CD8a molecule	Homo sapiens	35-38
7471050-1	1980	The induction of epidermal ornithine decarboxylase (EC 4.1.1.17) (ODC) following topical application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mice can be inhibited by topical application of putrescine, the product of the enzyme.	Tetradecanoylphorbol Acetate	168-171	ornithine decarboxylase, structural 1	Mus musculus	27-50
8877730-5	1996	Murine wt p53 derived from pSG5p53cD strongly repressed the IL-2 and IL-4 promoters in both cell lines induced by the phorbol ester TPA and the Ca2+ ionophore ionomycin but not, however, in uninduced cells.	Tetradecanoylphorbol Acetate	132-135	transformation related protein 53, pseudogene	Mus musculus	10-13
7471050-1	1980	The induction of epidermal ornithine decarboxylase (EC 4.1.1.17) (ODC) following topical application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mice can be inhibited by topical application of putrescine, the product of the enzyme.	Tetradecanoylphorbol Acetate	168-171	ornithine decarboxylase, structural 1	Mus musculus	66-69
7471050-2	1980	The degree of inhibition depended on both the dose and the time of putrescine application; application of 20 mumol of putrescine 2 hr after TPA treatment inhibited the induction of ODC activity by 50%.	Tetradecanoylphorbol Acetate	140-143	ornithine decarboxylase, structural 1	Mus musculus	181-184
7471050-5	1980	Putrescine, when added directly to the assay medium at a 100-mumol dose level inhibited by 97% the TPA-induced ODC activity, but the amount of putrescine (20 mumol) which gave 50% inhibition of the induction of ODC activity in vivo had no effect when added to the assay system.	Tetradecanoylphorbol Acetate	99-102	ornithine decarboxylase, structural 1	Mus musculus	111-114
7471050-5	1980	Putrescine, when added directly to the assay medium at a 100-mumol dose level inhibited by 97% the TPA-induced ODC activity, but the amount of putrescine (20 mumol) which gave 50% inhibition of the induction of ODC activity in vivo had no effect when added to the assay system.	Tetradecanoylphorbol Acetate	99-102	ornithine decarboxylase, structural 1	Mus musculus	211-214
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	208-211	CD8a molecule	Homo sapiens	265-268
31649684-7	2019	Ex vivo examination of CD38+HLA-DR+CD8+ T cells indicated that this subset of cells displayed stronger secretion of IFN-gamma and IL-2 before and after a 6-h stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (ION) relative to healthy CD38+HLA-DR+CD8+ T cells, indicating the functional feasibility of CD38+HLA-DR+CD8+ T cells.	Tetradecanoylphorbol Acetate	208-211	CD8a molecule	Homo sapiens	265-268
31376533-11	2019	Similarly, canonical second messengers and effectors of Galphaq (e.g. ionophore A23187-induced increase in intracellular Ca2+ and activation of PKC by PMA (phorbol 12-myristate 13-acetate)) inhibited Alk2(R206H)-mediated induction of ALP activity.	Tetradecanoylphorbol Acetate	156-187	activin A receptor type 1	Homo sapiens	200-204
6168406-1	1980	12-O-Tetradecanoylphorbol-13-acetate (TPA) and mezerein (MZ) are diterpene esters of similar structure and approximately equipotent on a molar basis as far as their hyperplasiogenic, inflammatory, and induction of ornithine decarboxylase activity effects in mouse skin are concerned.	Tetradecanoylphorbol Acetate	0-36	ornithine decarboxylase, structural 1	Mus musculus	214-237
8877730-5	1996	Murine wt p53 derived from pSG5p53cD strongly repressed the IL-2 and IL-4 promoters in both cell lines induced by the phorbol ester TPA and the Ca2+ ionophore ionomycin but not, however, in uninduced cells.	Tetradecanoylphorbol Acetate	132-135	interleukin 2	Mus musculus	60-64
6168406-1	1980	12-O-Tetradecanoylphorbol-13-acetate (TPA) and mezerein (MZ) are diterpene esters of similar structure and approximately equipotent on a molar basis as far as their hyperplasiogenic, inflammatory, and induction of ornithine decarboxylase activity effects in mouse skin are concerned.	Tetradecanoylphorbol Acetate	38-41	ornithine decarboxylase, structural 1	Mus musculus	214-237
8877730-5	1996	Murine wt p53 derived from pSG5p53cD strongly repressed the IL-2 and IL-4 promoters in both cell lines induced by the phorbol ester TPA and the Ca2+ ionophore ionomycin but not, however, in uninduced cells.	Tetradecanoylphorbol Acetate	132-135	interleukin 4	Mus musculus	69-73
8882959-5	1996	In support of these results, all three ATL cell lines established from these patients secreted M-CSF in vitro after stimulation with phorbol myristate acetate (PMA) or concanavalin A (Con A).	Tetradecanoylphorbol Acetate	133-158	colony stimulating factor 1	Homo sapiens	95-100
22283009-7	1980	A good correlation was observed between the induction of ornithine decarboxylase (ODC) activity and the formation of skin tumors by various doses of TPA.	Tetradecanoylphorbol Acetate	149-152	ornithine decarboxylase, structural 1	Mus musculus	57-80
22283009-7	1980	A good correlation was observed between the induction of ornithine decarboxylase (ODC) activity and the formation of skin tumors by various doses of TPA.	Tetradecanoylphorbol Acetate	149-152	ornithine decarboxylase, structural 1	Mus musculus	82-85
22283009-13	1980	The results indicate that a) the incidence of papillomas serves as a rapid (18 weeks) index for subsequent appearance of carcinomas, b) twice weekly applications of 10 nmol of TPA for 18 weeks following initiation of female CD-1 mice with 0.2 micromol of DMBA is an appropriate protocol for maximum tumor yield in initiation-promotion experiments, and c) ODC induction may be an important component of the mechanism of skin tumor promotion by TPA.	Tetradecanoylphorbol Acetate	176-179	ornithine decarboxylase, structural 1	Mus musculus	355-358
31362059-7	2019	Additionally, IL-9Rhigh CD8+ T cells following anti-TCR and PMA + ionomycin stimulation presented higher IL-2 and IL-17 expression, and lower IFN-gamma expression, than IL-9Rlow CD8+ T cells.	Tetradecanoylphorbol Acetate	60-63	interleukin 9	Sus scrofa	14-18
31362059-7	2019	Additionally, IL-9Rhigh CD8+ T cells following anti-TCR and PMA + ionomycin stimulation presented higher IL-2 and IL-17 expression, and lower IFN-gamma expression, than IL-9Rlow CD8+ T cells.	Tetradecanoylphorbol Acetate	60-63	CD8a molecule	Homo sapiens	24-27
8882959-5	1996	In support of these results, all three ATL cell lines established from these patients secreted M-CSF in vitro after stimulation with phorbol myristate acetate (PMA) or concanavalin A (Con A).	Tetradecanoylphorbol Acetate	160-163	colony stimulating factor 1	Homo sapiens	95-100
8709967-3	1996	Phorbol myristate acetate (PMA), an activator of protein kinase C (PKC) enhanced the NR transcript level in dark-grown leaves.	Tetradecanoylphorbol Acetate	0-25	nitrate reductase [NADH] 1	Zea mays	85-87
31484825-6	2019	PKC activation in vivo via injecting phorbol myristate acetate (PMA) or by constitutively active Gqalpha-Q209L in osteocytes and osteoblasts promoted FGF23 production.	Tetradecanoylphorbol Acetate	37-62	fibroblast growth factor 23	Mus musculus	150-155
31484825-6	2019	PKC activation in vivo via injecting phorbol myristate acetate (PMA) or by constitutively active Gqalpha-Q209L in osteocytes and osteoblasts promoted FGF23 production.	Tetradecanoylphorbol Acetate	64-67	fibroblast growth factor 23	Mus musculus	150-155
336799-3	1977	The recoveries of DNA, RNA, and protein on a per area basis were the same for the microwave and conventional heat separation procedures, and the TPA-induced ornithine decarboxylase levels were comparable.	Tetradecanoylphorbol Acetate	145-148	ornithine decarboxylase, structural 1	Mus musculus	157-180
8709967-3	1996	Phorbol myristate acetate (PMA), an activator of protein kinase C (PKC) enhanced the NR transcript level in dark-grown leaves.	Tetradecanoylphorbol Acetate	27-30	nitrate reductase [NADH] 1	Zea mays	85-87
8760241-14	1996	Phorbol esters (12-O-tetradecanoylphorbol-13-acetate) and forskolin stimulated Kcn1 gene expression 2.5- and 3.5-fold, respectively.	Tetradecanoylphorbol Acetate	16-52	potassium voltage-gated channel subfamily A member 10	Oryctolagus cuniculus	79-83
908030-3	1977	ODC was induced in both cell types by 12-O-tetradecanoyl-phorbol-13-acetate (TPA); maximal induction occurred 4 to 6 hr after the addition of the promoter to the medium of confluent cultures and was greater in transformed cells than in normal cells.	Tetradecanoylphorbol Acetate	38-75	ornithine decarboxylase, structural 1	Mus musculus	0-3
908030-3	1977	ODC was induced in both cell types by 12-O-tetradecanoyl-phorbol-13-acetate (TPA); maximal induction occurred 4 to 6 hr after the addition of the promoter to the medium of confluent cultures and was greater in transformed cells than in normal cells.	Tetradecanoylphorbol Acetate	77-80	ornithine decarboxylase, structural 1	Mus musculus	0-3
31002911-11	2019	In addition, phorbol-12-myristate-13-acetate (PMA, a activator of PKC) markedly attenuated the suppressive effects of propofol on ERK1/2 phosphorylation and NSC proliferation.	Tetradecanoylphorbol Acetate	13-44	protein kinase C, alpha	Rattus norvegicus	66-69
31002911-11	2019	In addition, phorbol-12-myristate-13-acetate (PMA, a activator of PKC) markedly attenuated the suppressive effects of propofol on ERK1/2 phosphorylation and NSC proliferation.	Tetradecanoylphorbol Acetate	46-49	protein kinase C, alpha	Rattus norvegicus	66-69
31285782-10	2019	Interestingly, treatment with either N-acetyl-L-cysteine (NAC) or diphenyleneiodonium (DPI) reduced the PMA-stimulated phosphorylation of these PTKs, implicating a potential role in cellular ROS signaling.	Tetradecanoylphorbol Acetate	104-107	X-linked Kx blood group	Homo sapiens	58-61
33846306-10	2021	However, we found that epidermis lacking both p21 and ASK1 reacquires increased sensitivity to DMBA/TPA-induced tumorigenesis.	Tetradecanoylphorbol Acetate	100-103	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	46-49
8843340-1	1996	Effects of p110, the catalytic subunit of PI-3 kinase, on induction of TPA response element-driven promoter by EGF was examined.	Tetradecanoylphorbol Acetate	71-74	spliceosome associated factor 3, U4/U6 recycling protein	Homo sapiens	11-15
33626581-11	2021	Levels of integrin alphaIIbbeta3 activation, fibrinogen binding, and aggregation were significantly lower in platelets from RUNX1L43S/L43S and RUNX1WT/L43S using phorbol 12-myristate 13-acetate (PMA), adenosine diphosphate (ADP), and high thrombin doses.	Tetradecanoylphorbol Acetate	195-198	runt related transcription factor 1	Mus musculus	124-129
33307168-5	2021	Heat shock protein 60 (HSP60), one of the chaperones in mitochondria was the major protein oxidized in TPA-treated HCCs.	Tetradecanoylphorbol Acetate	103-106	heat shock protein family D (Hsp60) member 1	Homo sapiens	0-21
33307168-5	2021	Heat shock protein 60 (HSP60), one of the chaperones in mitochondria was the major protein oxidized in TPA-treated HCCs.	Tetradecanoylphorbol Acetate	103-106	heat shock protein family D (Hsp60) member 1	Homo sapiens	23-28
8843340-1	1996	Effects of p110, the catalytic subunit of PI-3 kinase, on induction of TPA response element-driven promoter by EGF was examined.	Tetradecanoylphorbol Acetate	71-74	epidermal growth factor	Homo sapiens	111-114
33307168-6	2021	Moreover, depletion of HSP60 or expression of HSP60 cysteine mutant prevented TPA-induced phosphorylation of MAPKs.	Tetradecanoylphorbol Acetate	78-81	heat shock protein family D (Hsp60) member 1	Homo sapiens	23-28
31151753-8	2019	Either forskolin or phorbol 12 myristate 13-acetate can mimic hCG induction of Kctd11 expression.	Tetradecanoylphorbol Acetate	20-51	potassium channel tetramerization domain containing 11	Rattus norvegicus	79-85
8884387-3	1996	The NPY production in response to forskolin and phorbol 12-myristate 13-acetate (PMA) was taken as a criterion for regulated expression of NPY.	Tetradecanoylphorbol Acetate	48-79	neuropeptide Y	Homo sapiens	4-7
33307168-6	2021	Moreover, depletion of HSP60 or expression of HSP60 cysteine mutant prevented TPA-induced phosphorylation of MAPKs.	Tetradecanoylphorbol Acetate	78-81	heat shock protein family D (Hsp60) member 1	Homo sapiens	46-51
33307168-8	2021	TPA dissociated RKIP from HSP60 in both mitochondria and cytosol, concurrently with translocation of HSP60 and MAPK from mitochondria to cytosol, which was associated with robust phosphorylation of MAPKs in the cytosol.	Tetradecanoylphorbol Acetate	0-3	phosphatidylethanolamine binding protein 1	Homo sapiens	16-20
33307168-8	2021	TPA dissociated RKIP from HSP60 in both mitochondria and cytosol, concurrently with translocation of HSP60 and MAPK from mitochondria to cytosol, which was associated with robust phosphorylation of MAPKs in the cytosol.	Tetradecanoylphorbol Acetate	0-3	heat shock protein family D (Hsp60) member 1	Homo sapiens	26-31
33307168-8	2021	TPA dissociated RKIP from HSP60 in both mitochondria and cytosol, concurrently with translocation of HSP60 and MAPK from mitochondria to cytosol, which was associated with robust phosphorylation of MAPKs in the cytosol.	Tetradecanoylphorbol Acetate	0-3	heat shock protein family D (Hsp60) member 1	Homo sapiens	101-106
33307168-9	2021	Moreover, TPA induced opposite phenotypical changes of HCCs, G1 cell cycle arrest, and cell migration, which were prevented by mtROS scavengers and depletion of PKCdelta and HSP60.	Tetradecanoylphorbol Acetate	10-13	heat shock protein family D (Hsp60) member 1	Homo sapiens	174-179
31047687-1	2019	PURPOSE: We aimed to assess agreement on intravenous tissue-plasminogen activator (IV tPA) and mechanical thrombectomy (MT) management decisions in acute ischemic stroke (AIS) patients.	Tetradecanoylphorbol Acetate	86-89	chromosome 20 open reading frame 181	Homo sapiens	53-81
8884387-3	1996	The NPY production in response to forskolin and phorbol 12-myristate 13-acetate (PMA) was taken as a criterion for regulated expression of NPY.	Tetradecanoylphorbol Acetate	48-79	neuropeptide Y	Homo sapiens	139-142
33307168-10	2021	Consistently, TPA increased the migration-related genes, hydrogen peroxide inducible clone5, matrix metalloproteinase-1/3, laminingamma2, and suppressed the cell cycle regulator cyclin E1 (CCNE1) via PKCdelta/mtROS/HSP60/MAPK-axis.	Tetradecanoylphorbol Acetate	14-17	cyclin E1	Homo sapiens	178-187
8884387-3	1996	The NPY production in response to forskolin and phorbol 12-myristate 13-acetate (PMA) was taken as a criterion for regulated expression of NPY.	Tetradecanoylphorbol Acetate	81-84	neuropeptide Y	Homo sapiens	4-7
33307168-10	2021	Consistently, TPA increased the migration-related genes, hydrogen peroxide inducible clone5, matrix metalloproteinase-1/3, laminingamma2, and suppressed the cell cycle regulator cyclin E1 (CCNE1) via PKCdelta/mtROS/HSP60/MAPK-axis.	Tetradecanoylphorbol Acetate	14-17	cyclin E1	Homo sapiens	189-194
33307168-10	2021	Consistently, TPA increased the migration-related genes, hydrogen peroxide inducible clone5, matrix metalloproteinase-1/3, laminingamma2, and suppressed the cell cycle regulator cyclin E1 (CCNE1) via PKCdelta/mtROS/HSP60/MAPK-axis.	Tetradecanoylphorbol Acetate	14-17	heat shock protein family D (Hsp60) member 1	Homo sapiens	215-220
30642680-1	2019	BACKGROUND AND PURPOSE: Recent studies demonstrated the benefit of mechanical thrombectomy (MT) plus intravenous tissue-type plasminogen activator (IV-tPA) (MT-IV-tPA) in acute ischemic stroke.	Tetradecanoylphorbol Acetate	151-154	metallothionein 4	Homo sapiens	157-162
8884387-3	1996	The NPY production in response to forskolin and phorbol 12-myristate 13-acetate (PMA) was taken as a criterion for regulated expression of NPY.	Tetradecanoylphorbol Acetate	81-84	neuropeptide Y	Homo sapiens	139-142
30642680-2	2019	This study aimed to estimate the cost-utility of MT-IV-tPA compared with IV-tPA alone from the perspective of the French National Health Insurance.	Tetradecanoylphorbol Acetate	55-58	metallothionein 4	Homo sapiens	49-54
33307168-11	2021	Finally, c-jun and c-fos were required for TPA-induced expression of the migration-related genes and a novel microRNA, miR-6134, was responsible for TPA-induced suppression of CCNE1.	Tetradecanoylphorbol Acetate	43-46	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	9-14
33307168-11	2021	Finally, c-jun and c-fos were required for TPA-induced expression of the migration-related genes and a novel microRNA, miR-6134, was responsible for TPA-induced suppression of CCNE1.	Tetradecanoylphorbol Acetate	43-46	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	19-24
30642680-11	2019	The probabilistic analysis showed that the probability of MT-IV-TPA being cost-effective was 85.4% at threshold willingness-to-pay of $30,000 per QALY gained, reaching 98% at $50,000 per QALY gained.	Tetradecanoylphorbol Acetate	64-67	metallothionein 4	Homo sapiens	58-63
8884387-7	1996	Thus, forskolin + PMA led to an increased production of NPY.	Tetradecanoylphorbol Acetate	18-21	neuropeptide Y	Homo sapiens	56-59
33307168-11	2021	Finally, c-jun and c-fos were required for TPA-induced expression of the migration-related genes and a novel microRNA, miR-6134, was responsible for TPA-induced suppression of CCNE1.	Tetradecanoylphorbol Acetate	43-46	microRNA 6134	Homo sapiens	109-127
33307168-11	2021	Finally, c-jun and c-fos were required for TPA-induced expression of the migration-related genes and a novel microRNA, miR-6134, was responsible for TPA-induced suppression of CCNE1.	Tetradecanoylphorbol Acetate	43-46	cyclin E1	Homo sapiens	176-181
33307168-11	2021	Finally, c-jun and c-fos were required for TPA-induced expression of the migration-related genes and a novel microRNA, miR-6134, was responsible for TPA-induced suppression of CCNE1.	Tetradecanoylphorbol Acetate	149-152	microRNA 6134	Homo sapiens	109-127
8884387-8	1996	Exposure to PMA alone led to an increase in NPY production comparable to that seen after forskolin + PMA and this effect of PMA was dose-dependent.	Tetradecanoylphorbol Acetate	12-15	neuropeptide Y	Homo sapiens	44-47
33307168-11	2021	Finally, c-jun and c-fos were required for TPA-induced expression of the migration-related genes and a novel microRNA, miR-6134, was responsible for TPA-induced suppression of CCNE1.	Tetradecanoylphorbol Acetate	149-152	cyclin E1	Homo sapiens	176-181
30921339-7	2019	Phorbol ester 12-O-tetradecanoylphorbol-13-acetate (PMA), a PKC activator, up-regulated FGF23 production.	Tetradecanoylphorbol Acetate	14-50	protein kinase C, gamma	Rattus norvegicus	60-63
30921339-7	2019	Phorbol ester 12-O-tetradecanoylphorbol-13-acetate (PMA), a PKC activator, up-regulated FGF23 production.	Tetradecanoylphorbol Acetate	52-55	protein kinase C, gamma	Rattus norvegicus	60-63
8796788-5	1996	The action of IL-1 was greatly potentiated by the protein kinase C-activating phorbol ester, TPA, and inhibited by actinomycin D and cycloheximide.	Tetradecanoylphorbol Acetate	93-96	interleukin 1 alpha	Homo sapiens	14-18
32894784-12	2021	DISCUSSION: Thawed plasma retained the ability to inhibit tPA-induced fibrinolysis over 28-day storage at 1-4 C. alpha2 -AP levels were maintained in plasma thawed for 28 days and FFP.	Tetradecanoylphorbol Acetate	58-61	serpin family F member 2	Homo sapiens	113-123
8652819-3	1996	Using ultrastructural and confocal laser scanning microscopic (CLSM) image analysis, we observed that treatment of Dami cells, a human megakaryocytic cell line, with phorbol myristate acetate (PMA) induces the accumulation of PAI-1 and Vn in intracellular storage vacuoles that contain other alpha-granule proteins such as von Willebrand factor.	Tetradecanoylphorbol Acetate	166-191	serpin family E member 1	Homo sapiens	226-231
33128580-3	2021	Mechanistic investigation revealed that transforming growth factor beta-induced (TGFBI) acts as a potential downstream target of HMGB1 and lentivirus-mediated knockdown of TGFBI expression impaired phorbol-12-myristate-13-acetate (PMA) and all-trans retinoic acid (ATRA)-induced myeloid differentiation of AML cell lines.	Tetradecanoylphorbol Acetate	198-229	transforming growth factor beta induced	Homo sapiens	40-79
33128580-3	2021	Mechanistic investigation revealed that transforming growth factor beta-induced (TGFBI) acts as a potential downstream target of HMGB1 and lentivirus-mediated knockdown of TGFBI expression impaired phorbol-12-myristate-13-acetate (PMA) and all-trans retinoic acid (ATRA)-induced myeloid differentiation of AML cell lines.	Tetradecanoylphorbol Acetate	198-229	transforming growth factor beta induced	Homo sapiens	81-86
30886319-4	2019	Stimulation of P5424 cells by the calcium ionophore ionomycin together with PMA resulted in gene regulation of T-cell differentiation and activation markers, partially mimicking the CD4-CD8- double negative (DN) to double positive (DP) transition and some aspects of subsequent T-cell maturation and activation.	Tetradecanoylphorbol Acetate	76-79	CD8a molecule	Homo sapiens	186-189
30871060-9	2019	GA also inhibited the PMA-induced phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta), c-Jun N-terminal kinase (JNK) and p38 proteins (P38), suggesting that IKKalpha/beta, JNK and P38 activation is dependent on PKC activity.	Tetradecanoylphorbol Acetate	22-25	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	53-73
33128580-3	2021	Mechanistic investigation revealed that transforming growth factor beta-induced (TGFBI) acts as a potential downstream target of HMGB1 and lentivirus-mediated knockdown of TGFBI expression impaired phorbol-12-myristate-13-acetate (PMA) and all-trans retinoic acid (ATRA)-induced myeloid differentiation of AML cell lines.	Tetradecanoylphorbol Acetate	198-229	transforming growth factor beta induced	Homo sapiens	172-177
8652819-3	1996	Using ultrastructural and confocal laser scanning microscopic (CLSM) image analysis, we observed that treatment of Dami cells, a human megakaryocytic cell line, with phorbol myristate acetate (PMA) induces the accumulation of PAI-1 and Vn in intracellular storage vacuoles that contain other alpha-granule proteins such as von Willebrand factor.	Tetradecanoylphorbol Acetate	193-196	serpin family E member 1	Homo sapiens	226-231
33128580-3	2021	Mechanistic investigation revealed that transforming growth factor beta-induced (TGFBI) acts as a potential downstream target of HMGB1 and lentivirus-mediated knockdown of TGFBI expression impaired phorbol-12-myristate-13-acetate (PMA) and all-trans retinoic acid (ATRA)-induced myeloid differentiation of AML cell lines.	Tetradecanoylphorbol Acetate	231-234	transforming growth factor beta induced	Homo sapiens	40-79
33128580-3	2021	Mechanistic investigation revealed that transforming growth factor beta-induced (TGFBI) acts as a potential downstream target of HMGB1 and lentivirus-mediated knockdown of TGFBI expression impaired phorbol-12-myristate-13-acetate (PMA) and all-trans retinoic acid (ATRA)-induced myeloid differentiation of AML cell lines.	Tetradecanoylphorbol Acetate	231-234	transforming growth factor beta induced	Homo sapiens	81-86
30871060-9	2019	GA also inhibited the PMA-induced phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta), c-Jun N-terminal kinase (JNK) and p38 proteins (P38), suggesting that IKKalpha/beta, JNK and P38 activation is dependent on PKC activity.	Tetradecanoylphorbol Acetate	22-25	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	74-93
30871060-9	2019	GA also inhibited the PMA-induced phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta), c-Jun N-terminal kinase (JNK) and p38 proteins (P38), suggesting that IKKalpha/beta, JNK and P38 activation is dependent on PKC activity.	Tetradecanoylphorbol Acetate	22-25	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	80-93
33128580-3	2021	Mechanistic investigation revealed that transforming growth factor beta-induced (TGFBI) acts as a potential downstream target of HMGB1 and lentivirus-mediated knockdown of TGFBI expression impaired phorbol-12-myristate-13-acetate (PMA) and all-trans retinoic acid (ATRA)-induced myeloid differentiation of AML cell lines.	Tetradecanoylphorbol Acetate	231-234	transforming growth factor beta induced	Homo sapiens	172-177
8652819-6	1996	Reverse transcription-PCR analysis of RNA extracted from resting and PMA-treated Dami cells confirmed that PAI-1 mRNA expression was detectable at low levels in resting cells and induced by PMA treatment.	Tetradecanoylphorbol Acetate	69-72	serpin family E member 1	Homo sapiens	107-112
33182035-4	2020	In phorbol 12-myristate 13-acetate (PMA)-stimulated A549 airway epithelial cells, THCA pretreatment decreased the mRNA expression and secretion of interleukin (IL)-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecules 1 (ICAM-1), and reduced the mRNA expression of matrix metalloproteinase 9 (MMP-9).	Tetradecanoylphorbol Acetate	36-39	chemokine (C-C motif) ligand 2	Mus musculus	167-201
8655590-6	1996	Artificially activating PKC with phorbol myristate acetate or poisoning the calcium pump with thapsigargin stimulates transcytosis of pIgR, while the intracellular Ca chelator BAPTA-AM inhibits transcytosis.	Tetradecanoylphorbol Acetate	33-58	polymeric immunoglobulin receptor	Homo sapiens	134-138
33182035-4	2020	In phorbol 12-myristate 13-acetate (PMA)-stimulated A549 airway epithelial cells, THCA pretreatment decreased the mRNA expression and secretion of interleukin (IL)-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecules 1 (ICAM-1), and reduced the mRNA expression of matrix metalloproteinase 9 (MMP-9).	Tetradecanoylphorbol Acetate	36-39	chemokine (C-C motif) ligand 2	Mus musculus	203-208
30651883-7	2019	Following incubation with PMA and ionomycin, morphine significantly decreased Th1 cells and the Th1/Th2 ratio in the CRC group.	Tetradecanoylphorbol Acetate	26-29	negative elongation factor complex member C/D	Homo sapiens	78-81
30651883-7	2019	Following incubation with PMA and ionomycin, morphine significantly decreased Th1 cells and the Th1/Th2 ratio in the CRC group.	Tetradecanoylphorbol Acetate	26-29	negative elongation factor complex member C/D	Homo sapiens	96-99
8761946-2	1996	Since fos/jun and steroid hormones interact to regulate gene expression, we asked whether phorbol-12-myristate-13-acetate (PMA), which stimulates binding of fos/jun to AP1 sites, transactivates the avian beta 3 integrin gene and, if so, does the phorbol ester modulate 1,25(OH)2D3 induction of the gene.	Tetradecanoylphorbol Acetate	90-121	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	204-210
32940288-1	2020	An RGD-peptide conjugated ruthenium(ii) complex has been developed, which functions as a two-photon absorption (TPA) photodynamic therapy (PDT) agent for ablating tumours by selectively targeting the mitochondria of integrin alphavbeta3-rich tumour cells.	Tetradecanoylphorbol Acetate	112-115	integrin subunit alpha V	Homo sapiens	216-236
33019942-8	2021	It was observed that lapachol above 0.5 microM inhibited the activation of MMP-2 and MMP-9 stimulated by PMA.	Tetradecanoylphorbol Acetate	105-108	matrix metallopeptidase 9	Homo sapiens	85-90
31061278-5	2019	The increased production of MMP-9 and MMP-13 in the articular chondrocytes induced by tumor necrosis factor-alpha (TNF-alpha) or phorbol-12-myristate-13-acetate (PMA) was significantly suppressed by concomitant treatment with 1alpha,25(OH)2D3 in vitro.	Tetradecanoylphorbol Acetate	129-160	matrix metallopeptidase 9	Rattus norvegicus	28-33
8761946-2	1996	Since fos/jun and steroid hormones interact to regulate gene expression, we asked whether phorbol-12-myristate-13-acetate (PMA), which stimulates binding of fos/jun to AP1 sites, transactivates the avian beta 3 integrin gene and, if so, does the phorbol ester modulate 1,25(OH)2D3 induction of the gene.	Tetradecanoylphorbol Acetate	123-126	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	204-210
8648737-2	1996	We have found that the human T leukemia/lymphotropic virus type 1 viral protein Tax can also strongly costimulate expression of interleukin-2 (IL-2), IL-3, and granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA in T cells activated with the phorbol ester phorbol myristate acetate (PMA) and calcium ionophore, which can mimic activation through the antigen specific T-cell receptor.	Tetradecanoylphorbol Acetate	267-292	colony stimulating factor 2	Homo sapiens	160-208
32887693-7	2020	Ubc9-mediated SUMOylated alpha-synuclein avoided PMA-induced lysosomal degradation due to its high solubility.	Tetradecanoylphorbol Acetate	49-52	ubiquitin-conjugating enzyme E2I	Mus musculus	0-4
8648737-2	1996	We have found that the human T leukemia/lymphotropic virus type 1 viral protein Tax can also strongly costimulate expression of interleukin-2 (IL-2), IL-3, and granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA in T cells activated with the phorbol ester phorbol myristate acetate (PMA) and calcium ionophore, which can mimic activation through the antigen specific T-cell receptor.	Tetradecanoylphorbol Acetate	267-292	colony stimulating factor 2	Homo sapiens	210-216
8648737-2	1996	We have found that the human T leukemia/lymphotropic virus type 1 viral protein Tax can also strongly costimulate expression of interleukin-2 (IL-2), IL-3, and granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA in T cells activated with the phorbol ester phorbol myristate acetate (PMA) and calcium ionophore, which can mimic activation through the antigen specific T-cell receptor.	Tetradecanoylphorbol Acetate	294-297	colony stimulating factor 2	Homo sapiens	160-208
31061278-5	2019	The increased production of MMP-9 and MMP-13 in the articular chondrocytes induced by tumor necrosis factor-alpha (TNF-alpha) or phorbol-12-myristate-13-acetate (PMA) was significantly suppressed by concomitant treatment with 1alpha,25(OH)2D3 in vitro.	Tetradecanoylphorbol Acetate	129-160	matrix metallopeptidase 13	Rattus norvegicus	38-44
31061278-5	2019	The increased production of MMP-9 and MMP-13 in the articular chondrocytes induced by tumor necrosis factor-alpha (TNF-alpha) or phorbol-12-myristate-13-acetate (PMA) was significantly suppressed by concomitant treatment with 1alpha,25(OH)2D3 in vitro.	Tetradecanoylphorbol Acetate	162-165	matrix metallopeptidase 9	Rattus norvegicus	28-33
31061278-5	2019	The increased production of MMP-9 and MMP-13 in the articular chondrocytes induced by tumor necrosis factor-alpha (TNF-alpha) or phorbol-12-myristate-13-acetate (PMA) was significantly suppressed by concomitant treatment with 1alpha,25(OH)2D3 in vitro.	Tetradecanoylphorbol Acetate	162-165	matrix metallopeptidase 13	Rattus norvegicus	38-44
8648737-2	1996	We have found that the human T leukemia/lymphotropic virus type 1 viral protein Tax can also strongly costimulate expression of interleukin-2 (IL-2), IL-3, and granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA in T cells activated with the phorbol ester phorbol myristate acetate (PMA) and calcium ionophore, which can mimic activation through the antigen specific T-cell receptor.	Tetradecanoylphorbol Acetate	294-297	colony stimulating factor 2	Homo sapiens	210-216
32932813-7	2020	In parallel, the addition of RA to either CD3/CD28 or phorbol myristate acetate (PMA)/ionomycin during QVOA and TILDA, respectively, was shown to augment reactivation of the replication-competent viral reservoir in anti-retroviral therapy (ART)-suppressed RMs as shown by a greater than 2.3-fold increase for QVOA and 1 to 2-fold increments for multi-spliced RNA per million CD4+ T cells.	Tetradecanoylphorbol Acetate	81-84	CD4 molecule	Macaca mulatta	375-378
8648737-3	1996	Reporter constructs also showed strong synergy between both stimuli and showed that Tax and the PMA-Ca2+ ionophore act through different regions of the IL-2 and GM-CSF genes.	Tetradecanoylphorbol Acetate	96-99	colony stimulating factor 2	Homo sapiens	161-167
8648737-6	1996	Tax protein mutants, however, showed that a pathway(s) other than NF-kappaB/rel induction could also cooperate with the PMA-Ca2+ ionophore to activate the GM-CSF and IL-2 genes.	Tetradecanoylphorbol Acetate	120-123	colony stimulating factor 2	Homo sapiens	155-161
8649402-7	1996	The ability of an interfering ERK-2 mutant to block phorbol myristate acetate and v-ras-dependent PAC-1 transcription indicates that mitogen-activated protein kinase activation is necessary for these stimuli to induce transcription of the PAC-1 gene in T cells.	Tetradecanoylphorbol Acetate	52-77	dual specificity phosphatase 2	Mus musculus	239-244
30392833-3	2019	We compared time metrics and outcomes of stroke patients who were assessed and received intravenous recombinant tissue plasminogen activator (IV-tPA) via TM during after-hours with those during on-hours.	Tetradecanoylphorbol Acetate	145-148	chromosome 20 open reading frame 181	Homo sapiens	112-140
8621938-4	1996	An immunoblot analysis revealed that both ATPo and the cross-linking of FcRs led to tyrosine phosphorylation of 44- and 110-kDa proteins, which thus suggested that these tyrosine-phosphorylated proteins are involved in a modulation of the degranulation process following an elevation of [Ca2+]i. Pretreatment with PMA inhibited the FcR-induced [Ca2+]i increase, while not inhibiting the ATPo-induced one, thus suggesting that ATPo can mobilize [Ca2+]i even when protein kinase C (PKC) has already been activated.	Tetradecanoylphorbol Acetate	314-317	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	Mus musculus	42-46
32758447-8	2020	Phorbol-myristate-acetate-induced formation of neutrophil extracellular traps (NETs) was reduced in affected cells (p = 0.015), and phagocytosis assays in MPO-deficient mice and human cells revealed altered neutrophil function and impaired clearance of neutrophils by monocytes (efferocytosis) allowing prolonged neutrophil persistence in inflammatory skin.	Tetradecanoylphorbol Acetate	0-25	myeloperoxidase	Mus musculus	155-158
8621938-4	1996	An immunoblot analysis revealed that both ATPo and the cross-linking of FcRs led to tyrosine phosphorylation of 44- and 110-kDa proteins, which thus suggested that these tyrosine-phosphorylated proteins are involved in a modulation of the degranulation process following an elevation of [Ca2+]i. Pretreatment with PMA inhibited the FcR-induced [Ca2+]i increase, while not inhibiting the ATPo-induced one, thus suggesting that ATPo can mobilize [Ca2+]i even when protein kinase C (PKC) has already been activated.	Tetradecanoylphorbol Acetate	314-317	Fc receptor	Mus musculus	72-75
32983167-5	2020	Topical administration of PM1 or PM2 led to attenuated PMA-induced ear edema, reduced local production of the pro-inflammatory chemokines MCP-1 and CXCL-1 as well as the cytokine IL-6.	Tetradecanoylphorbol Acetate	55-58	transmembrane protein 11	Homo sapiens	26-29
8621938-4	1996	An immunoblot analysis revealed that both ATPo and the cross-linking of FcRs led to tyrosine phosphorylation of 44- and 110-kDa proteins, which thus suggested that these tyrosine-phosphorylated proteins are involved in a modulation of the degranulation process following an elevation of [Ca2+]i. Pretreatment with PMA inhibited the FcR-induced [Ca2+]i increase, while not inhibiting the ATPo-induced one, thus suggesting that ATPo can mobilize [Ca2+]i even when protein kinase C (PKC) has already been activated.	Tetradecanoylphorbol Acetate	314-317	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	Mus musculus	387-391
8621938-4	1996	An immunoblot analysis revealed that both ATPo and the cross-linking of FcRs led to tyrosine phosphorylation of 44- and 110-kDa proteins, which thus suggested that these tyrosine-phosphorylated proteins are involved in a modulation of the degranulation process following an elevation of [Ca2+]i. Pretreatment with PMA inhibited the FcR-induced [Ca2+]i increase, while not inhibiting the ATPo-induced one, thus suggesting that ATPo can mobilize [Ca2+]i even when protein kinase C (PKC) has already been activated.	Tetradecanoylphorbol Acetate	314-317	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	Mus musculus	387-391
31529243-6	2020	Topical DMBA and TPA application resulted in a significant increase in the protein levels, immunoreactivity, and mRNA expression of HRAS, HIF1alpha, Akt, and PTEN (p &lt; 0.05).	Tetradecanoylphorbol Acetate	17-20	Harvey rat sarcoma virus oncogene	Mus musculus	132-136
8631923-9	1996	Stimulation of protein kinase C (PKC) activity with the phorbol ester phorbol 12-myristate 13-acetate enhances paxillin phosphorylation, while two selective inhibitors of PKC, GF109203X and chelerythrine chloride, effectively block the phosphorylation of paxillin induced in response to vitronectin adhesion.	Tetradecanoylphorbol Acetate	70-101	paxillin	Homo sapiens	111-119
8625537-9	1996	Similar but transient inhibition of most T-cell products (IL-2, IL-3, IL-4, IL-5, IL-10, TNF-beta and GM-CSF) was noted in the PMA/ionomycin-containing cultures.	Tetradecanoylphorbol Acetate	127-130	interleukin 3	Homo sapiens	64-68
32577560-3	2020	Objective: To screen the effectiveness of a novel IFN-alpha/beta signalling inhibitor in the development reduction of skin lesions in IMQ and TPA mice models of psoriasis.	Tetradecanoylphorbol Acetate	142-145	interferon alpha	Mus musculus	50-59
8625537-9	1996	Similar but transient inhibition of most T-cell products (IL-2, IL-3, IL-4, IL-5, IL-10, TNF-beta and GM-CSF) was noted in the PMA/ionomycin-containing cultures.	Tetradecanoylphorbol Acetate	127-130	colony stimulating factor 2	Homo sapiens	102-108
8796364-2	1996	Neutrophils from patients treated with nifedipine showed a significantly lower superoxide generation stimulated by phorbol myristate acetate (PMA) (50 ng mL-1), opsonized zymosan (1 mg mL-1) or formyl-methionyl-leucylphenylalanine (FMLP) (10(-7) M), whereas superoxide generation by neutrophils of patients receiving diltiazem or verapamil showed only a slight and insignificant reduction compared with controls.	Tetradecanoylphorbol Acetate	115-140	L1 cell adhesion molecule	Mus musculus	154-158
32321446-8	2020	Moreover, NCEH1 was upregulated through RORalpha via a phorbol myristate acetate-dependent mechanism during macrophage differentiation from THP1 cells.	Tetradecanoylphorbol Acetate	55-80	RAR related orphan receptor A	Homo sapiens	40-48
8796364-2	1996	Neutrophils from patients treated with nifedipine showed a significantly lower superoxide generation stimulated by phorbol myristate acetate (PMA) (50 ng mL-1), opsonized zymosan (1 mg mL-1) or formyl-methionyl-leucylphenylalanine (FMLP) (10(-7) M), whereas superoxide generation by neutrophils of patients receiving diltiazem or verapamil showed only a slight and insignificant reduction compared with controls.	Tetradecanoylphorbol Acetate	142-145	L1 cell adhesion molecule	Mus musculus	154-158
8666674-4	1996	Treatment of Jurkat cells with phorbol myristate acetate increased the expression of sialylated Lewis(x)-related sLe(x)related epitopes and induced the synthesis of E-selectin ligands functional at physiologic levels of linear shear-stress.	Tetradecanoylphorbol Acetate	31-56	selectin E	Homo sapiens	165-175
32276922-5	2020	Our data revealed that SAP 1C9-hi CD8 T cells clearly displayed higher polyfunctional responses versus SAP 1C9-lo CD8 T cells following PMA/ionomycin stimulation.	Tetradecanoylphorbol Acetate	136-139	CD8a molecule	Homo sapiens	34-37
8601602-3	1996	The mitosis-specific vimentin phosphorylation by PKC was dramatically enhanced by treatment with a PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), while no phosphorylation of vimentin by PKC was observed in interphase cells treated with TPA.	Tetradecanoylphorbol Acetate	114-150	vimentin	Homo sapiens	21-29
32191627-0	2020	3,5-Dicaffeoyl-epi-quinic acid inhibits the PMA-stimulated activation and expression of MMP-9 but not MMP-2 via downregulation of MAPK pathway.	Tetradecanoylphorbol Acetate	44-47	matrix metallopeptidase 9	Homo sapiens	88-93
8601602-3	1996	The mitosis-specific vimentin phosphorylation by PKC was dramatically enhanced by treatment with a PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), while no phosphorylation of vimentin by PKC was observed in interphase cells treated with TPA.	Tetradecanoylphorbol Acetate	152-155	vimentin	Homo sapiens	21-29
31922892-7	2020	Additional experiments assessing mitoROS generation using the mitochondrial-targeted ROS indicator, MitoSOX, revealed that a PKCbeta-mitochondrial oxidant signaling pathway can be pharmacologically stimulated by the PKC activator phorbol 12-myristate 13-acetate (PMA) in primary cultures of pulmonary artery smooth muscle cells (PASMCs) from control neonates.	Tetradecanoylphorbol Acetate	230-261	protein kinase C, beta	Rattus norvegicus	125-132
8601602-3	1996	The mitosis-specific vimentin phosphorylation by PKC was dramatically enhanced by treatment with a PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), while no phosphorylation of vimentin by PKC was observed in interphase cells treated with TPA.	Tetradecanoylphorbol Acetate	248-251	vimentin	Homo sapiens	21-29
31922892-7	2020	Additional experiments assessing mitoROS generation using the mitochondrial-targeted ROS indicator, MitoSOX, revealed that a PKCbeta-mitochondrial oxidant signaling pathway can be pharmacologically stimulated by the PKC activator phorbol 12-myristate 13-acetate (PMA) in primary cultures of pulmonary artery smooth muscle cells (PASMCs) from control neonates.	Tetradecanoylphorbol Acetate	230-261	protein kinase C, beta	Rattus norvegicus	125-128
31922892-7	2020	Additional experiments assessing mitoROS generation using the mitochondrial-targeted ROS indicator, MitoSOX, revealed that a PKCbeta-mitochondrial oxidant signaling pathway can be pharmacologically stimulated by the PKC activator phorbol 12-myristate 13-acetate (PMA) in primary cultures of pulmonary artery smooth muscle cells (PASMCs) from control neonates.	Tetradecanoylphorbol Acetate	263-266	protein kinase C, beta	Rattus norvegicus	125-132
8771559-8	1996	Addition of the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) also caused increases in TH and DBH mRNA levels.	Tetradecanoylphorbol Acetate	43-74	dopamine beta-hydroxylase	Homo sapiens	113-116
31922892-7	2020	Additional experiments assessing mitoROS generation using the mitochondrial-targeted ROS indicator, MitoSOX, revealed that a PKCbeta-mitochondrial oxidant signaling pathway can be pharmacologically stimulated by the PKC activator phorbol 12-myristate 13-acetate (PMA) in primary cultures of pulmonary artery smooth muscle cells (PASMCs) from control neonates.	Tetradecanoylphorbol Acetate	263-266	protein kinase C, beta	Rattus norvegicus	125-128
8771559-8	1996	Addition of the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) also caused increases in TH and DBH mRNA levels.	Tetradecanoylphorbol Acetate	76-79	dopamine beta-hydroxylase	Homo sapiens	113-116
31939617-8	2020	Taken together, these results demonstrated that morin hydrate reduced the metastatic potential in TPA-treated MCF-7 human breast cancer cells via the inhibition of MMPs, uPA and uPAR, and the underlying Akt/GSK-3beta/c-Fos pathway.	Tetradecanoylphorbol Acetate	98-101	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	217-222
8771559-9	1996	In protein kinase C-downregulated cells pretreated with PMA for 24 h, the stimulatory effect of PACAP on TH and DBH gene expression was diminished.	Tetradecanoylphorbol Acetate	56-59	dopamine beta-hydroxylase	Homo sapiens	112-115
8780174-3	1996	The stimulatory effects of phorbol 12-myristate 13-acetate and bacterial lipopolysaccharide (LPS) on E-selectin expression were also downregulated by the forskolin-rolipram combination and by SpcAMPS.	Tetradecanoylphorbol Acetate	27-58	selectin E	Homo sapiens	101-111
31796994-6	2020	Notably, treatment of cells with ionomycin, a calcium ionophore and a known activator of ADAM10, or with phorbol 12-myristate 13-acetate, an activator of ADAM17, dramatically increases the release of soluble PD-L1 to the media.	Tetradecanoylphorbol Acetate	105-136	ADAM metallopeptidase domain 17	Homo sapiens	154-160
8703583-3	1996	Scatchard analysis of 125I-labeled IGF-I to FLG 29.1 cells revealed the presence of a single high affinity binding site in both untreated and TPA-treated cells with a similar Kd value (0.3 +/- 0.2 nmol/L and 0.4 +/- 0.1 nmol/L, respectively).	Tetradecanoylphorbol Acetate	142-145	filaggrin	Homo sapiens	44-47
31806018-7	2019	In splenocytes stimulated either with H. meleagridis antigen or PMA/ionomycin, IFN-gamma-producing CD4+ T cells from infected chickens increased in comparison to cells from non-infected birds 2 weeks and 5 weeks post-infection.	Tetradecanoylphorbol Acetate	64-67	interferon gamma	Gallus gallus	79-88
31806018-8	2019	Additionally, an increase of IFN-gamma-producing CD4-CD8beta- cells upon H. meleagridis antigen and PMA/ionomycin stimulation was detected.	Tetradecanoylphorbol Acetate	100-103	interferon gamma	Gallus gallus	29-38
31361541-5	2019	Furthermore, IL-17A stimulation resulted in mRNA and protein expression of scavenger receptor (LOX-1) in phorbol 12-myristate 13-acetate (PMA)-activated U937 cells.	Tetradecanoylphorbol Acetate	105-136	interleukin 17A	Homo sapiens	13-19
8703583-6	1996	Northern analysis demonstrated that mRNA for IGF-I receptor was expressed by both untreated and TPA-treated FLG 29.1 cells.	Tetradecanoylphorbol Acetate	96-99	filaggrin	Homo sapiens	108-111
31361541-5	2019	Furthermore, IL-17A stimulation resulted in mRNA and protein expression of scavenger receptor (LOX-1) in phorbol 12-myristate 13-acetate (PMA)-activated U937 cells.	Tetradecanoylphorbol Acetate	138-141	interleukin 17A	Homo sapiens	13-19
8703583-7	1996	In addition, FLG 29.1 cells released in the conditioned medium IGFBP-2 and IGFBP-4, whose expression was increased by TPA treatment as demonstrated by ligand and immunoblot analyses.	Tetradecanoylphorbol Acetate	118-121	filaggrin	Homo sapiens	13-16
8935929-3	1996	To investigate the role of UCH-L1 in TPA-induced Reh differentiation and apoptosis, molecular and chemical inhibition was used.	Tetradecanoylphorbol Acetate	37-40	ubiquitin C-terminal hydrolase L1	Homo sapiens	27-33
8935929-7	1996	TPA-induced changes in Reh cell growth and morphology, UCH-L1 protein expression, apoptosis contour, surface phenotype, and enzymatic profile were assessed in the presence or absence of NaBH4, AODN or SODN.	Tetradecanoylphorbol Acetate	0-3	ubiquitin C-terminal hydrolase L1	Homo sapiens	55-61
31325464-0	2019	Sites phosphorylated in human alpha1B-adrenoceptors in response to noradrenaline and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	85-110	alpha-1-B glycoprotein	Homo sapiens	30-37
8671615-5	1996	We have previously shown that proper cross-linking of TCR-CD3 with LFA-1, CD4 or CD8 inhibited glucocorticoid-induced thymocyte apoptosis in vitro, and that a proper combination of the calcium ionophore, ionomycin and the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), mimicked the inhibitory effect.	Tetradecanoylphorbol Acetate	256-287	T cell receptor alpha variable 6-3	Mus musculus	54-57
8671615-5	1996	We have previously shown that proper cross-linking of TCR-CD3 with LFA-1, CD4 or CD8 inhibited glucocorticoid-induced thymocyte apoptosis in vitro, and that a proper combination of the calcium ionophore, ionomycin and the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), mimicked the inhibitory effect.	Tetradecanoylphorbol Acetate	256-287	integrin alpha L	Mus musculus	67-72
31358321-8	2019	Phorbol 12-myristate 13-acetate (PMA)-stimulated HuB-transduced cells demonstrated significantly enhanced activation of endogenous c-Fos and CREB dependent cascades.	Tetradecanoylphorbol Acetate	0-31	ELAV like RNA binding protein 2	Homo sapiens	49-52
31358321-8	2019	Phorbol 12-myristate 13-acetate (PMA)-stimulated HuB-transduced cells demonstrated significantly enhanced activation of endogenous c-Fos and CREB dependent cascades.	Tetradecanoylphorbol Acetate	0-31	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-136
8671615-6	1996	Here we determined whether this combination of ionomycin and PMA induces differentiation of isolated DP thymocytes from normal and TCR transgenic mice.	Tetradecanoylphorbol Acetate	61-64	T cell receptor alpha variable 6-3	Mus musculus	131-134
31358321-8	2019	Phorbol 12-myristate 13-acetate (PMA)-stimulated HuB-transduced cells demonstrated significantly enhanced activation of endogenous c-Fos and CREB dependent cascades.	Tetradecanoylphorbol Acetate	0-31	cAMP responsive element binding protein 1	Homo sapiens	141-145
8778231-4	1996	Adrenocorticotropin (ACTH) treatment increased c-myc mRNA accumulation dose- and time-dependently up to more than 5-fold (on average), with the maximal effect at 2 h. (Bu)2cAMP and 12-O-tetradecanoyl phorbol 13-acetate (TPA) also induced c-myc gene expression.	Tetradecanoylphorbol Acetate	181-218	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	47-52
31358321-8	2019	Phorbol 12-myristate 13-acetate (PMA)-stimulated HuB-transduced cells demonstrated significantly enhanced activation of endogenous c-Fos and CREB dependent cascades.	Tetradecanoylphorbol Acetate	33-36	ELAV like RNA binding protein 2	Homo sapiens	49-52
31358321-8	2019	Phorbol 12-myristate 13-acetate (PMA)-stimulated HuB-transduced cells demonstrated significantly enhanced activation of endogenous c-Fos and CREB dependent cascades.	Tetradecanoylphorbol Acetate	33-36	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-136
31358321-8	2019	Phorbol 12-myristate 13-acetate (PMA)-stimulated HuB-transduced cells demonstrated significantly enhanced activation of endogenous c-Fos and CREB dependent cascades.	Tetradecanoylphorbol Acetate	33-36	cAMP responsive element binding protein 1	Homo sapiens	141-145
8778231-4	1996	Adrenocorticotropin (ACTH) treatment increased c-myc mRNA accumulation dose- and time-dependently up to more than 5-fold (on average), with the maximal effect at 2 h. (Bu)2cAMP and 12-O-tetradecanoyl phorbol 13-acetate (TPA) also induced c-myc gene expression.	Tetradecanoylphorbol Acetate	220-223	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	47-52
8778231-7	1996	H-7 totally abolished ACTH-, TPA- and (Bu)2cAMP-induced c-myc expression, while staurosporine inhibited the stimulatory effects of ACTH and TPA, and HA1004 weakly inhibited the effects of ACTH and (Bu)2cAMP.	Tetradecanoylphorbol Acetate	29-32	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	56-61
31540162-7	2019	In addition, fisetin treatment significantly decreased the secretion of Th1/Th-17 pro-inflammatory cytokines, particularly IFN-gamma and IL-17A by 12-O-tetradecanolylphorbol 13-acetate (TPA)-stimulated NHEKs and anti-CD3/CD28-activated human PBMCs.	Tetradecanoylphorbol Acetate	186-189	negative elongation factor complex member C/D	Homo sapiens	72-75
8597533-8	1996	The peaks of Cx26 and Cx43 expression and Cx31.1 inhibition appeared 12 h after TPA application and 24 h after OA and chrysarobin application.	Tetradecanoylphorbol Acetate	80-83	gap junction protein, beta 2	Mus musculus	13-17
31540162-7	2019	In addition, fisetin treatment significantly decreased the secretion of Th1/Th-17 pro-inflammatory cytokines, particularly IFN-gamma and IL-17A by 12-O-tetradecanolylphorbol 13-acetate (TPA)-stimulated NHEKs and anti-CD3/CD28-activated human PBMCs.	Tetradecanoylphorbol Acetate	186-189	interleukin 17A	Homo sapiens	137-143
8562968-4	1996	Brief treatment with phorbol 12-myristate 13-acetate (PMA) caused a significant increase in HEL cell adhesion to monoclonal antibodies (MoAbs) specific for activated alpha IIb beta 3 (PAC1 or pl-55).	Tetradecanoylphorbol Acetate	21-52	ADCYAP receptor type I	Homo sapiens	184-188
31146918-5	2019	RANK mRNA expression in pre-osteoclastic RAW264.7 cells was induced by Phorbol12-myristate13-acetate (PMA) and suppressed by protein kinase C (PKC) inhibitor calphostin C. In RAW264.7 cells, Fos knockdown by siRNA blocked the inducible effect of PMA on RANK expression.	Tetradecanoylphorbol Acetate	71-100	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	Mus musculus	0-4
31146918-5	2019	RANK mRNA expression in pre-osteoclastic RAW264.7 cells was induced by Phorbol12-myristate13-acetate (PMA) and suppressed by protein kinase C (PKC) inhibitor calphostin C. In RAW264.7 cells, Fos knockdown by siRNA blocked the inducible effect of PMA on RANK expression.	Tetradecanoylphorbol Acetate	102-105	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	Mus musculus	0-4
8562968-4	1996	Brief treatment with phorbol 12-myristate 13-acetate (PMA) caused a significant increase in HEL cell adhesion to monoclonal antibodies (MoAbs) specific for activated alpha IIb beta 3 (PAC1 or pl-55).	Tetradecanoylphorbol Acetate	54-57	ADCYAP receptor type I	Homo sapiens	184-188
29564917-6	2019	Losartan + apelin yielded a further significant decrease in ATR1 gene expression, glycaemic indices, serum TGs and TPA versus Apelin only.	Tetradecanoylphorbol Acetate	115-118	apelin	Rattus norvegicus	11-17
8775226-2	1996	We hypothesised that tPA would also be present in CSF during fibrinolysis after intraventricular haemorrhage.	Tetradecanoylphorbol Acetate	21-24	colony stimulating factor 2	Homo sapiens	50-53
8775226-3	1996	We measured tPA antigen in CSF from 13 normal newborn infants and 14 infants with post-haemorrhagic ventricular dilatation (PHVD).	Tetradecanoylphorbol Acetate	12-15	colony stimulating factor 2	Homo sapiens	27-30
8775226-4	1996	tPA was undetectable or at the limit of detection (1 microgram/l) in normal CSF.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 2	Homo sapiens	76-79
30707387-3	2019	After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages.	Tetradecanoylphorbol Acetate	33-64	interleukin 10	Homo sapiens	220-225
30707387-3	2019	After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages.	Tetradecanoylphorbol Acetate	66-69	interleukin 10	Homo sapiens	204-218
8775226-5	1996	The CSF tPA concentration ranged from 1.3 to 3.5 micrograms/l in the infants with PHVD.	Tetradecanoylphorbol Acetate	8-11	colony stimulating factor 2	Homo sapiens	4-7
30707387-3	2019	After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages.	Tetradecanoylphorbol Acetate	66-69	interleukin 10	Homo sapiens	220-225
8775226-6	1996	Serial tapping in one infant showed persistence of tPA in the CSF from 3 to 8 weeks of age.	Tetradecanoylphorbol Acetate	51-54	colony stimulating factor 2	Homo sapiens	62-65
8775226-7	1996	We conclude that endogenous tPA may be part of the physiological response to intraventricular haemorrhage or may be present as a result of passive diffusion into the CSF.	Tetradecanoylphorbol Acetate	28-31	colony stimulating factor 2	Homo sapiens	166-169
8848429-8	1996	Inhibition of protein kinase C activity by pretreatment with 1 microM chelerythrine chloride or by prolonged stimulation with 50 ng/ml tetradecanoyl phorbol acetate (TPA) attenuated the induction of Egr-1 mRNA by 2 microM PGE2.	Tetradecanoylphorbol Acetate	135-164	early growth response 1	Mus musculus	199-204
30936203-4	2019	Our results demonstrate that direct activation of PKC via the phorbol ester phorbol 12-myristate 13-acetate (PMA) mimics CXCL12-mediated desensitization, internalization, ubiquitination, and lysosomal trafficking of CXCR4.	Tetradecanoylphorbol Acetate	76-107	C-X-C motif chemokine receptor 4	Homo sapiens	216-221
30936203-4	2019	Our results demonstrate that direct activation of PKC via the phorbol ester phorbol 12-myristate 13-acetate (PMA) mimics CXCL12-mediated desensitization, internalization, ubiquitination, and lysosomal trafficking of CXCR4.	Tetradecanoylphorbol Acetate	109-112	C-X-C motif chemokine receptor 4	Homo sapiens	216-221
8848429-8	1996	Inhibition of protein kinase C activity by pretreatment with 1 microM chelerythrine chloride or by prolonged stimulation with 50 ng/ml tetradecanoyl phorbol acetate (TPA) attenuated the induction of Egr-1 mRNA by 2 microM PGE2.	Tetradecanoylphorbol Acetate	166-169	early growth response 1	Mus musculus	199-204
8543831-4	1996	In monocytic Mono Mac6 cells stimulated with the phorbolester tetradecanoyl phorbolacetate (TPA), thioredoxin was found to augment the expression of TNF at the protein and mRNA levels.	Tetradecanoylphorbol Acetate	62-90	thioredoxin	Homo sapiens	98-109
8543831-4	1996	In monocytic Mono Mac6 cells stimulated with the phorbolester tetradecanoyl phorbolacetate (TPA), thioredoxin was found to augment the expression of TNF at the protein and mRNA levels.	Tetradecanoylphorbol Acetate	92-95	thioredoxin	Homo sapiens	98-109
31027698-8	2019	These patients also showed impaired signal transducer and activator of transcription-1 (STAT1) signaling upon stimulation with IL-6 and phorbol 12-myristate 13-acetate (PMA), and T-Cells from a healthy donor that were treated for four days with IL-6 displayed a similar muting of STAT signaling, which verified the effect seen in patient samples.	Tetradecanoylphorbol Acetate	136-167	signal transducer and activator of transcription 1	Homo sapiens	36-86
8543831-6	1996	Treatment of TPA-stimulated Mono Mac6 cells resulted in a strong potentiation of secreted IL-1 bioactivity and expression of IL-1 alpha and IL-8 mRNA.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 alpha	Homo sapiens	90-94
31027698-8	2019	These patients also showed impaired signal transducer and activator of transcription-1 (STAT1) signaling upon stimulation with IL-6 and phorbol 12-myristate 13-acetate (PMA), and T-Cells from a healthy donor that were treated for four days with IL-6 displayed a similar muting of STAT signaling, which verified the effect seen in patient samples.	Tetradecanoylphorbol Acetate	136-167	signal transducer and activator of transcription 1	Homo sapiens	88-93
30203271-4	2019	The cells differentiated with retinoic acid and 12-o-tetradecanoylphorbol-13-acetate show a significant increase in the expression of tyrosine hydroxylase, vesicular monoamine transporter-2, and dopamine transporter.	Tetradecanoylphorbol Acetate	48-84	solute carrier family 6 member 3	Homo sapiens	195-215
8543831-6	1996	Treatment of TPA-stimulated Mono Mac6 cells resulted in a strong potentiation of secreted IL-1 bioactivity and expression of IL-1 alpha and IL-8 mRNA.	Tetradecanoylphorbol Acetate	13-16	interleukin 1 alpha	Homo sapiens	125-135
8552594-6	1996	Activation of PKC epsilon was further confirmed in terms of PKC epsilon-dependent expression of a phorbol 12-tetradecanoate 13-acetate response element (TRE)-luciferase reporter.	Tetradecanoylphorbol Acetate	98-134	protein kinase C epsilon	Homo sapiens	14-25
30620003-9	2019	Results: Carotid plaque burden [total plaque area (TPA)] was associated with higher levels of phosphate (TPA, r = 0.20, P &lt; 0.01) and FGF-23 (r = 0.19, P &lt; 0.01).	Tetradecanoylphorbol Acetate	51-54	fibroblast growth factor 23	Homo sapiens	137-143
30915077-5	2019	PMA-induced NETs were decorated with annexins, azurocidin and histone H3, whereas A23187-induced NETs were decorated with granule proteins including CAMP/LL37, CRISP3, lipocalin and MMP8, histones H1.0, H1.4, and H1.5, interleukin-8, protein-arginine deiminase-4 (PADI4), and alpha-enolase.	Tetradecanoylphorbol Acetate	0-3	azurocidin 1	Homo sapiens	47-57
8552594-6	1996	Activation of PKC epsilon was further confirmed in terms of PKC epsilon-dependent expression of a phorbol 12-tetradecanoate 13-acetate response element (TRE)-luciferase reporter.	Tetradecanoylphorbol Acetate	98-134	protein kinase C epsilon	Homo sapiens	60-71
8615653-0	1996	Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21).	Tetradecanoylphorbol Acetate	56-59	H3 histone pseudogene 16	Homo sapiens	139-142
30590137-8	2019	KA repressed the PMA-induced phosphorylation of Akt, c-Jun N-terminal kinase (JNK) 1/2, and p38 MAPK, which are signaling molecules upstream of MMP-9 expression.	Tetradecanoylphorbol Acetate	17-20	matrix metallopeptidase 9	Homo sapiens	144-149
30658316-7	2019	TPA upregulated claudin 1 levels in all HBC cell lines analyzed.	Tetradecanoylphorbol Acetate	0-3	claudin 1	Homo sapiens	16-25
30466990-0	2018	Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCalpha/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	132-135	matrix metallopeptidase 9	Homo sapiens	42-47
30466990-9	2018	CONCLUSION: Orientin inhibits migratory and invasive responses by suppressing MMP-9 and IL-8 expression through mitigation of TPA-induced PKCalpha and ERK activation, as well as the nuclear translocation of AP-1 and STAT3.	Tetradecanoylphorbol Acetate	126-129	matrix metallopeptidase 9	Homo sapiens	78-83
8717351-6	1996	Activation of protein kinase C with tetradecanoylphorbol acetate (1 mumol/l) caused a strong increase in the number of neurones expressing proenkephalin mRNA.	Tetradecanoylphorbol Acetate	36-64	proenkephalin	Rattus norvegicus	139-152
30658316-9	2019	TPA treatment also led to an accumulation of claudin 1 in the cytoplasm.	Tetradecanoylphorbol Acetate	0-3	claudin 1	Homo sapiens	45-54
8598484-6	1996	Of interest, both activated CD8+ TCR-alpha beta+ iIEL subsets, but not fresh cells, were able to mediate Fas-based killing when triggered with PMA and CA2+ ionophore.	Tetradecanoylphorbol Acetate	143-146	T cell receptor alpha chain	Mus musculus	33-42
30529522-1	2019	INTRODUCTION: Intra-arterial tissue plasminogen activator (IA-tPA) has been widely used in conjunction with mechanical thrombectomy (MT) or as rescue therapy.	Tetradecanoylphorbol Acetate	62-65	chromosome 20 open reading frame 181	Homo sapiens	29-57
30519264-3	2018	In the present study, SE1 potently inhibited gelatin digestion by MMP-9 induced by phorbol 12-myristate 13-acetate (PMA) and migration of human fibrosarcoma HT1080 cells in dose-dependent manner.	Tetradecanoylphorbol Acetate	83-114	matrix metallopeptidase 9	Homo sapiens	66-71
30519264-3	2018	In the present study, SE1 potently inhibited gelatin digestion by MMP-9 induced by phorbol 12-myristate 13-acetate (PMA) and migration of human fibrosarcoma HT1080 cells in dose-dependent manner.	Tetradecanoylphorbol Acetate	116-119	matrix metallopeptidase 9	Homo sapiens	66-71
21594311-7	1996	Furthermore, azatyrosine inhibited activation of the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element in response to stimulation by oncogenic c-ErbB-2.	Tetradecanoylphorbol Acetate	53-89	erb-b2 receptor tyrosine kinase 2	Mus musculus	153-161
30389973-6	2018	Moreover, pre-treatment with Bay 61-3606 (a Syk inhibitor) or Bay 11-7082 (a NF-kappaB inhibitor) abolished the PMA-induced Thy-1 up-regulation and migration inhibition in endothelial cells.	Tetradecanoylphorbol Acetate	112-115	spleen tyrosine kinase	Danio rerio	44-47
30838000-8	2019	Upon in vitro activation with PMA plus ionomycin or IL12 plus IL18, fewer MAIT cells isolated from the young adult group expressed IFN-gamma, IL17A and Granzyme B then cells from other age groups while the proportion of cells that expressed TNF-alpha was similar.	Tetradecanoylphorbol Acetate	30-33	interleukin 17A	Homo sapiens	142-147
21594311-7	1996	Furthermore, azatyrosine inhibited activation of the 12-O-tetradecanoylphorbol-13-acetate (TPA) response element in response to stimulation by oncogenic c-ErbB-2.	Tetradecanoylphorbol Acetate	91-94	erb-b2 receptor tyrosine kinase 2	Mus musculus	153-161
21594328-1	1996	The effects of genistein, a soybean isoflavone, on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced expression of c-fos and c-jun in CD-1 mouse skin have been investigated.	Tetradecanoylphorbol Acetate	51-88	FBJ osteosarcoma oncogene	Mus musculus	117-122
30325010-10	2019	Intracellular cytokine staining following phorbol myristate acetate (PMA)/ionomycin stimulation demonstrated that  &gt; 30% CD4+ T cells positive for IL-22 express the innate markers gammadeltaT cell receptor and/or CD56, with much lower proportions for IL-17A+ cells (P &lt; 0 001).	Tetradecanoylphorbol Acetate	69-72	interleukin 22	Homo sapiens	150-155
21594328-1	1996	The effects of genistein, a soybean isoflavone, on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced expression of c-fos and c-jun in CD-1 mouse skin have been investigated.	Tetradecanoylphorbol Acetate	90-93	FBJ osteosarcoma oncogene	Mus musculus	117-122
30274867-12	2018	CONCLUSION: The oral KISS1-54 DNA vaccine with fused tPA signal peptide was more effective than that KISS1-10 DNA vaccine in suppressing fertility of female rats.	Tetradecanoylphorbol Acetate	53-56	KiSS-1 metastasis-suppressor	Rattus norvegicus	21-26
21594328-2	1996	A promoting dose (8.5 mu mol) of TPA significantly increases transcript levels of c-fos, and 2.7 and 3.2 kb c-jun mRNA in mouse skin by 7.0-, 3.2-, and 1.7-fold, respectively.	Tetradecanoylphorbol Acetate	33-36	FBJ osteosarcoma oncogene	Mus musculus	82-87
21594328-4	1996	Suppression of c-fos was more pronounced than that of c-jun, and at a dose of 10 mu mol genistein, TPA-induced c-fos expression was almost completely diminished.	Tetradecanoylphorbol Acetate	99-102	FBJ osteosarcoma oncogene	Mus musculus	15-20
30566262-8	2019	Up-regulation of cytokines (TSLP, IL-4, IL-5, IL-13, RANTES) in human mast cells treated with phorbol 12-myristate 13-acetate and calcium ionophore was also suppressed by boehmite.	Tetradecanoylphorbol Acetate	94-125	C-C motif chemokine ligand 5	Homo sapiens	53-59
21594328-4	1996	Suppression of c-fos was more pronounced than that of c-jun, and at a dose of 10 mu mol genistein, TPA-induced c-fos expression was almost completely diminished.	Tetradecanoylphorbol Acetate	99-102	FBJ osteosarcoma oncogene	Mus musculus	111-116
21594328-6	1996	Effect of application time of genistein on TPA-induced c-fos expression was also investigated.	Tetradecanoylphorbol Acetate	43-46	FBJ osteosarcoma oncogene	Mus musculus	55-60
29775091-3	2018	This study showed that skin nuclear VDR expression in TPA-treated mice has a daily rhythm with the peak at the middle of active period.	Tetradecanoylphorbol Acetate	54-57	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	36-39
21594328-7	1996	The results showed that topical application of 10 mu mol genistein 30 min prior to, simultaneously, and 30 min after tumor promoter treatment can equally suppress TPA-induced c-fos expression.	Tetradecanoylphorbol Acetate	163-166	FBJ osteosarcoma oncogene	Mus musculus	175-180
29775091-5	2018	These data suggest that chronotherapeutic profiles of maxacalcitol partly depend on the daily rhythm of skin nuclear VDR in TPA-treated mice.	Tetradecanoylphorbol Acetate	124-127	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	117-120
30511745-9	2019	Restoration of diacylglycerol-mediated signalling in lipin1 deficient myoblasts by phorbol 12-myristate 13-acetate transiently activated PKC and HDAC5, and upregulated MEF2c expression.	Tetradecanoylphorbol Acetate	83-114	lipin 1	Mus musculus	53-59
21594328-10	1996	It is hypothesized that the inhibitory effect of genistein on TPA-induced c-fos expression may be through the modulation of mitogen-activated protein (MAP) kinase in vivo.	Tetradecanoylphorbol Acetate	62-65	FBJ osteosarcoma oncogene	Mus musculus	74-79
12237694-2	1996	Some functions and characteristics of the three PAI-1 were compared, such as the inhibiting effect on tPA, the activation by denaturation, the stability to thermal or pH changes, and the activation by fibrinogen and heparin.	Tetradecanoylphorbol Acetate	102-105	serpin family E member 1	Homo sapiens	48-53
30634395-8	2019	Ammonia decreased the level of phosphorylated Sp1, and the effect was reinforced by long-term incubation with PKC modulator, phorbol 12-myristate 13-acetate, which is a treatment likely to dephosphorylate Sp1.	Tetradecanoylphorbol Acetate	125-156	protein kinase C, delta	Mus musculus	110-113
30310408-0	2018	Successful development of squamous cell carcinoma and hyperplasia in RGEN-mediated p27 KO mice after the treatment of DMBA and TPA.	Tetradecanoylphorbol Acetate	127-130	cyclin-dependent kinase inhibitor 1B	Mus musculus	83-86
7503727-3	1995	TPA treatment also reduced prohormone convertase-1 (PC-1) protein and increased PC-1 mRNA levels.	Tetradecanoylphorbol Acetate	0-3	proprotein convertase subtilisin/kexin type 1	Homo sapiens	27-50
30061889-6	2018	Moreover, CD49dhigh CD4+ T cells showed a Th1-like memory phenotype, characterized by high expression of CD44 and CXCR3; low expression of CD62L and CCR7; rapid production of IFN-gamma, tumor necrosis factor-alpha, and IL-2 upon stimulation with phorbol myristate acetate and ionomycin; and rapid proliferation upon stimulation with anti-CD3 and anti-CD28 antibodies.	Tetradecanoylphorbol Acetate	246-271	negative elongation factor complex member C/D	Homo sapiens	42-45
30137206-7	2018	Inflammation was attenuated in Klk6-/- skin following chronic exposure to TPA, indicated by markedly low expression of proinflammatory cytokines, in direct contrast to wt.	Tetradecanoylphorbol Acetate	74-77	kallikrein related-peptidase 6	Mus musculus	31-35
7503727-3	1995	TPA treatment also reduced prohormone convertase-1 (PC-1) protein and increased PC-1 mRNA levels.	Tetradecanoylphorbol Acetate	0-3	proprotein convertase subtilisin/kexin type 1	Homo sapiens	52-56
7503727-3	1995	TPA treatment also reduced prohormone convertase-1 (PC-1) protein and increased PC-1 mRNA levels.	Tetradecanoylphorbol Acetate	0-3	proprotein convertase subtilisin/kexin type 1	Homo sapiens	80-84
8543026-4	1995	After blocking of LTC4 metabolism with the H2O2 scavenger catalase, a PMA-provoked suppression of the conversion of LTA4 to LTC4 was observed, indicating PKC-dependent regulation of LTC4 synthase activity.	Tetradecanoylphorbol Acetate	70-73	leukotriene C4 synthase	Homo sapiens	182-195
31194000-0	2019	Forskolin and Phorbol 12-myristate 13-acetate modulates the expression pattern of AP-1 factors and cell cycle regulators in estrogen-responsive MCF-7 cells.	Tetradecanoylphorbol Acetate	14-45	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-86
8547036-5	1995	In response to stimulation with phorbol-12-myristate-13 acetate (PMA), the 16T(-) cells produced more IL-4 and IFN-gamma, whereas the 35T(-) and MH-1 cells exhibited increased secretion of IFN-gamma, but still no IL-4 or IL-4 mRNA production.	Tetradecanoylphorbol Acetate	32-63	interleukin 4	Mus musculus	102-106
29940858-13	2018	A locus on Chr4 associated with both ACLR and TPA resides within DOCK2, a gene that has been shown to promote immune cell migration and invasion in synovitis, an important predictor of ACLR.	Tetradecanoylphorbol Acetate	46-49	dedicator of cytokinesis 2	Homo sapiens	65-70
8547036-5	1995	In response to stimulation with phorbol-12-myristate-13 acetate (PMA), the 16T(-) cells produced more IL-4 and IFN-gamma, whereas the 35T(-) and MH-1 cells exhibited increased secretion of IFN-gamma, but still no IL-4 or IL-4 mRNA production.	Tetradecanoylphorbol Acetate	65-68	interleukin 4	Mus musculus	102-106
30545441-5	2018	Also, Tat-ATOX1 protein markedly inhibited LPS- and TPA-induced inflammatory responses by decreasing cyclooxygenase- 2 (COX-2) and inducible nitric oxide synthase (iNOS) and further inhibited phosphorylation of mitogen activated protein kinases (MAPKs; JNK, ERK and p38) and the nuclear factor-kappaB (NF-kappaB) signaling pathway.	Tetradecanoylphorbol Acetate	52-55	antioxidant 1 copper chaperone	Homo sapiens	10-15
8547036-5	1995	In response to stimulation with phorbol-12-myristate-13 acetate (PMA), the 16T(-) cells produced more IL-4 and IFN-gamma, whereas the 35T(-) and MH-1 cells exhibited increased secretion of IFN-gamma, but still no IL-4 or IL-4 mRNA production.	Tetradecanoylphorbol Acetate	65-68	interleukin 4	Mus musculus	213-217
30466979-8	2018	In addition, EWSS and EYSS could markedly inhibit the MPO activity in the ears of TPA-, AA- or CO-treated mice.	Tetradecanoylphorbol Acetate	82-85	myeloperoxidase	Mus musculus	54-57
7497525-4	1995	We purified human peripheral NK cells (&gt; 98% CD56+) and found that PMA and ionomycin treatment upregulated FasL message and stimulated the NK cells to lyse a Fas+ TC.	Tetradecanoylphorbol Acetate	70-73	neural cell adhesion molecule 1	Homo sapiens	48-52
30133131-8	2018	These results indicate that mLU8C-PU inhibits migratory and invasive responses in MCF-7 breast cancer cells by suppressing MMP-9 and IL-8 expression through mitigating TPA-induced PKCalpha, JNK activation, and the nuclear translocation of AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	168-171	matrix metallopeptidase 9	Homo sapiens	123-128
29926068-9	2018	Co-immunoprecipitation results showed that the interaction between TRPC1 and Orai1 was reduced by Calhex231 plus TPA, Ro31-8220 or Go6976 addition in the Spermine-stimulated HUVECs.	Tetradecanoylphorbol Acetate	113-116	transient receptor potential cation channel subfamily C member 1	Homo sapiens	67-72
29926068-9	2018	Co-immunoprecipitation results showed that the interaction between TRPC1 and Orai1 was reduced by Calhex231 plus TPA, Ro31-8220 or Go6976 addition in the Spermine-stimulated HUVECs.	Tetradecanoylphorbol Acetate	113-116	ORAI calcium release-activated calcium modulator 1	Homo sapiens	77-82
29926068-10	2018	Double knockdown of Trpc1 and Orai1 genes significantly decreased [Ca2+]i level and NO production in all of the Spermine+Ca2+, Calhex231+TPA+Spermine+Ca2+, Ro31-8220+Spermine+Ca2+ and Go6976+Spermine+Ca2+ groups.	Tetradecanoylphorbol Acetate	137-140	transient receptor potential cation channel subfamily C member 1	Homo sapiens	20-25
29926068-10	2018	Double knockdown of Trpc1 and Orai1 genes significantly decreased [Ca2+]i level and NO production in all of the Spermine+Ca2+, Calhex231+TPA+Spermine+Ca2+, Ro31-8220+Spermine+Ca2+ and Go6976+Spermine+Ca2+ groups.	Tetradecanoylphorbol Acetate	137-140	ORAI calcium release-activated calcium modulator 1	Homo sapiens	30-35
7497525-4	1995	We purified human peripheral NK cells (&gt; 98% CD56+) and found that PMA and ionomycin treatment upregulated FasL message and stimulated the NK cells to lyse a Fas+ TC.	Tetradecanoylphorbol Acetate	70-73	Fas ligand	Homo sapiens	110-114
8789601-11	1995	PKC-epsilon was not detected in SK-N-MC cell lines but translocated with TPA treatment in the other three cell lines.	Tetradecanoylphorbol Acetate	73-76	protein kinase C epsilon	Homo sapiens	0-11
29660338-7	2018	It was found that TPA induced interaction between the transcriptional factors Sp1 and P53 producing Sp1-p53 complex which strongly interacted with c-Jun only after short exposure to TPA.	Tetradecanoylphorbol Acetate	18-21	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	147-152
29660338-7	2018	It was found that TPA induced interaction between the transcriptional factors Sp1 and P53 producing Sp1-p53 complex which strongly interacted with c-Jun only after short exposure to TPA.	Tetradecanoylphorbol Acetate	182-185	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	147-152
30337297-5	2018	MRTFAOE increased binding of SRF to genomic sites and enhanced TPA-induced expression of SRF target genes.	Tetradecanoylphorbol Acetate	63-66	serum response factor	Homo sapiens	29-32
30337297-5	2018	MRTFAOE increased binding of SRF to genomic sites and enhanced TPA-induced expression of SRF target genes.	Tetradecanoylphorbol Acetate	63-66	serum response factor	Homo sapiens	89-92
30337297-6	2018	The TPA-induced genes are predicted to be regulated by SRF and ETS factors, whereas those upregulated by TPA plus MRTFAOE lack ETS binding motifs, and MRTFAOE skews SRF binding to genomic regions with CArG sites in regions relatively lacking in ETS binding motifs.	Tetradecanoylphorbol Acetate	4-7	serum response factor	Homo sapiens	55-58
30337297-6	2018	The TPA-induced genes are predicted to be regulated by SRF and ETS factors, whereas those upregulated by TPA plus MRTFAOE lack ETS binding motifs, and MRTFAOE skews SRF binding to genomic regions with CArG sites in regions relatively lacking in ETS binding motifs.	Tetradecanoylphorbol Acetate	4-7	serum response factor	Homo sapiens	165-168
29660338-8	2018	In addition, TPA treatment highly induced the expression of CREB which attached to the Sp1-p53 complex mainly after a long exposure to TPA.	Tetradecanoylphorbol Acetate	13-16	cAMP responsive element binding protein 1	Homo sapiens	60-64
29660338-8	2018	In addition, TPA treatment highly induced the expression of CREB which attached to the Sp1-p53 complex mainly after a long exposure to TPA.	Tetradecanoylphorbol Acetate	135-138	cAMP responsive element binding protein 1	Homo sapiens	60-64
7478534-0	1995	ETS1 transactivates the human GM-CSF promoter in Jurkat T cells stimulated with PMA and ionomycin.	Tetradecanoylphorbol Acetate	80-83	ETS proto-oncogene 1, transcription factor	Homo sapiens	0-4
29660338-9	2018	A strong binding of sp1, p53 and CREB proteins with HTLV-1 LTR and strong binding of NF-kappaB with HIV-1 LTR were observed after long (24 h) and short (6 h) exposures to TPA respectively by Chip assay.	Tetradecanoylphorbol Acetate	171-174	cAMP responsive element binding protein 1	Homo sapiens	33-37
29660338-10	2018	These results support the possibility that sp1, p53 and CREB are involved in the TPA induced HTLV-1 LTR expression while TPA activation of HIV-1 LTR seems to be dependent on PKC activity through the NF-kappaB pathway.	Tetradecanoylphorbol Acetate	81-84	cAMP responsive element binding protein 1	Homo sapiens	56-60
30308980-8	2018	This formulation effectively ameliorated TPA-induced hyperplasia, by reducing skin edema, epidermal thickness, MPO activity and COX-2 expression.	Tetradecanoylphorbol Acetate	41-44	myeloperoxidase	Mus musculus	111-114
7478534-0	1995	ETS1 transactivates the human GM-CSF promoter in Jurkat T cells stimulated with PMA and ionomycin.	Tetradecanoylphorbol Acetate	80-83	colony stimulating factor 2	Homo sapiens	30-36
7478534-9	1995	The GM-CSF promoter, modified in this way to be ETS1 specific, is fully responsive to PMA/ionomycin induction, in addition to ETS1 transactivation in the presence of PMA and ionomycin.	Tetradecanoylphorbol Acetate	86-89	colony stimulating factor 2	Homo sapiens	4-10
30076961-9	2018	Unexpectedly, FSAP-treated fibrinogen or plasma exhibited a significantly faster tPA-driven lysis, which correlated exclusively with cleavage of fibrinogen and not with activation of plasminogen activators.	Tetradecanoylphorbol Acetate	81-84	hyaluronan binding protein 2	Homo sapiens	14-18
7478534-9	1995	The GM-CSF promoter, modified in this way to be ETS1 specific, is fully responsive to PMA/ionomycin induction, in addition to ETS1 transactivation in the presence of PMA and ionomycin.	Tetradecanoylphorbol Acetate	86-89	ETS proto-oncogene 1, transcription factor	Homo sapiens	48-52
7478534-9	1995	The GM-CSF promoter, modified in this way to be ETS1 specific, is fully responsive to PMA/ionomycin induction, in addition to ETS1 transactivation in the presence of PMA and ionomycin.	Tetradecanoylphorbol Acetate	166-169	colony stimulating factor 2	Homo sapiens	4-10
29292524-8	2018	When stimulated with PMA/ionomycin, CD4+ T cells from women with EP presented significantly higher interferon (IFN)-gamma and interleukin (IL)-17 secretion, and lower transforming growth factor (TGF)-beta secretion.	Tetradecanoylphorbol Acetate	21-24	interleukin 17A	Homo sapiens	126-145
30208917-8	2018	However, whereas phorbol 12-myristate 13-acetate/ionomycin stimulation induced the production of both interferon-gamma and IL-17 by breast duct MAIT cells, bacterially exposed breast carcinoma cells elicited a strongly IL-17-biased response.	Tetradecanoylphorbol Acetate	17-48	interleukin 17A	Homo sapiens	123-128
7478534-9	1995	The GM-CSF promoter, modified in this way to be ETS1 specific, is fully responsive to PMA/ionomycin induction, in addition to ETS1 transactivation in the presence of PMA and ionomycin.	Tetradecanoylphorbol Acetate	166-169	ETS proto-oncogene 1, transcription factor	Homo sapiens	48-52
7478534-9	1995	The GM-CSF promoter, modified in this way to be ETS1 specific, is fully responsive to PMA/ionomycin induction, in addition to ETS1 transactivation in the presence of PMA and ionomycin.	Tetradecanoylphorbol Acetate	166-169	ETS proto-oncogene 1, transcription factor	Homo sapiens	126-130
30015874-4	2018	P2X7R may serve a crucial role in the development of atherosclerosis; therefore, the present study aimed to determine whether P2X7R regulated the expression of EMMPRIN and MMP-9 in phorbol 12-myristate 13-acetate (PMA)-induced macrophages.	Tetradecanoylphorbol Acetate	181-212	matrix metallopeptidase 9	Homo sapiens	172-177
7499234-8	1995	Antibodies to Egr-1 completely supershift the PMA-induced complex.	Tetradecanoylphorbol Acetate	46-49	early growth response 1	Homo sapiens	14-19
30058806-0	2018	Nobiletin and 5-Hydroxy-6,7,8,3",4"-pentamethoxyflavone Ameliorate 12- O-Tetradecanoylphorbol-13-acetate-Induced Psoriasis-Like Mouse Skin Lesions by Regulating the Expression of Ki-67 and Proliferating Cell Nuclear Antigen and the Differentiation of CD4+ T Cells through Mitogen-Activated Protein Kinase Signaling Pathways.	Tetradecanoylphorbol Acetate	67-104	antigen identified by monoclonal antibody Ki 67	Mus musculus	179-184
7488130-3	1995	Further studies showed that 12-O-tetradecanoyl phorbol 13-acetate (TPA) enhanced the accumulation of WAF1; cells refractory to TPA still increased their levels of WAF1 mRNA when exposed to IL-1.	Tetradecanoylphorbol Acetate	67-70	interleukin 1 alpha	Homo sapiens	189-193
30058806-0	2018	Nobiletin and 5-Hydroxy-6,7,8,3",4"-pentamethoxyflavone Ameliorate 12- O-Tetradecanoylphorbol-13-acetate-Induced Psoriasis-Like Mouse Skin Lesions by Regulating the Expression of Ki-67 and Proliferating Cell Nuclear Antigen and the Differentiation of CD4+ T Cells through Mitogen-Activated Protein Kinase Signaling Pathways.	Tetradecanoylphorbol Acetate	67-104	proliferating cell nuclear antigen	Mus musculus	189-223
30058806-8	2018	The expression levels in TPA, Nob, and 5-HPMF groups were 0.649 +- 0.094, 0.218 +- 0.034, and 0.193 +- 0.042 for Ki-67 and 0.753 +- 0.114, 0.315 +- 0.094, and 0.294 +- 0.035 for PCNA, respectively.	Tetradecanoylphorbol Acetate	25-28	antigen identified by monoclonal antibody Ki 67	Mus musculus	113-118
30058806-8	2018	The expression levels in TPA, Nob, and 5-HPMF groups were 0.649 +- 0.094, 0.218 +- 0.034, and 0.193 +- 0.042 for Ki-67 and 0.753 +- 0.114, 0.315 +- 0.094, and 0.294 +- 0.035 for PCNA, respectively.	Tetradecanoylphorbol Acetate	25-28	proliferating cell nuclear antigen	Mus musculus	178-182
7592827-7	1995	Measurement of intracellular cholesterol esterification suggested that PMA induced translocation of intracellular cholesterol to a specific pool for apoA-I-mediated efflux, and a protein kinase C inhibitor reversed this effect.	Tetradecanoylphorbol Acetate	71-74	apolipoprotein A1	Rattus norvegicus	149-155
8562483-6	1995	When two tyrosine kinase inhibitors (tyrphostins RG50864 and RG13022) were incorporated into the treatment regimens, the TPA-induced epidermal hyperplasia and cell proliferation were effectively blocked, and the TPA-stimulated EGFr tyrosine phosphorylation was significantly reduced.	Tetradecanoylphorbol Acetate	121-124	epidermal growth factor receptor	Mus musculus	227-231
7592765-4	1995	Hypermethylation within the SRE of the low density lipoprotein receptor promoter was observed when cells were treated with cholesterol synthesis inhibitors, insulin, or phorbol 12-myristate 13-acetate, suggesting that the SRE regulates this promoter through sterol-independent as well as sterol-dependent mechanisms.	Tetradecanoylphorbol Acetate	169-200	low density lipoprotein receptor	Homo sapiens	39-71
30038030-0	2018	Tumor promoter TPA activates Wnt/beta-catenin signaling in a casein kinase 1-dependent manner.	Tetradecanoylphorbol Acetate	15-18	catenin (cadherin associated protein), beta 1	Mus musculus	33-45
30038030-2	2018	Activation of Wnt/beta-catenin signaling has a decisive role in mouse skin carcinogenesis, but it remains unclear how TPA activates Wnt/beta-catenin signaling in mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	118-121	catenin (cadherin associated protein), beta 1	Mus musculus	136-148
30038030-3	2018	Here, we found that TPA could enhance Wnt/beta-catenin signaling in a casein kinase 1 (CK1) epsilon/delta-dependent manner.	Tetradecanoylphorbol Acetate	20-23	catenin (cadherin associated protein), beta 1	Mus musculus	42-54
30038030-5	2018	TPA further induced the phosphorylation of LRP6 at Thr1479 and Ser1490 and the formation of a CK1epsilon-LRP6-axin1 complex, leading to an increase in cytosolic beta-catenin.	Tetradecanoylphorbol Acetate	0-3	catenin (cadherin associated protein), beta 1	Mus musculus	161-173
30038030-6	2018	Moreover, TPA increased the association of beta-catenin with TCF4E in a CK1epsilon/delta-dependent way, resulting in the activation of Wnt target genes.	Tetradecanoylphorbol Acetate	10-13	catenin (cadherin associated protein), beta 1	Mus musculus	43-55
30038030-7	2018	Consistently, treatment with a selective CK1epsilon/delta inhibitor SR3029 suppressed TPA-induced skin tumor formation in vivo, probably through blocking Wnt/beta-catenin signaling.	Tetradecanoylphorbol Acetate	86-89	catenin (cadherin associated protein), beta 1	Mus musculus	158-170
30038030-8	2018	Taken together, our study has identified a pathway by which TPA activates Wnt/beta-catenin signaling.	Tetradecanoylphorbol Acetate	60-63	catenin (cadherin associated protein), beta 1	Mus musculus	78-90
29627456-3	2018	Comparative flow cytometric analyses of lymphocyte subsets stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin revealed differences in expression of IL-17A by CD4, CD8, and gammadelta T cells across ruminants and swine species.	Tetradecanoylphorbol Acetate	75-106	CD4 molecule	Sus scrofa	175-178
29627456-3	2018	Comparative flow cytometric analyses of lymphocyte subsets stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin revealed differences in expression of IL-17A by CD4, CD8, and gammadelta T cells across ruminants and swine species.	Tetradecanoylphorbol Acetate	108-111	CD4 molecule	Sus scrofa	175-178
29303837-1	2018	BACKGROUND: For ischemic stroke, the chance of improved recovery is directly impacted by length of time from symptom onset to administration of intravenous tissue plasminogen activator (IV tPA).	Tetradecanoylphorbol Acetate	189-192	chromosome 20 open reading frame 181	Homo sapiens	156-184
29079502-11	2018	Distal MCAO and tPA application with LB1 or DMSO showed that treatment significantly decreased the infarct volume and the hemorrhage area.	Tetradecanoylphorbol Acetate	16-19	cytoskeleton associated protein 2	Mus musculus	37-40
29079502-13	2018	These data suggest that LB1 can be used as an adjuvant agent to tPA.	Tetradecanoylphorbol Acetate	64-67	cytoskeleton associated protein 2	Mus musculus	24-27
29115558-4	2018	In vivo, bryostatin 1 prevented the TPA-mediated increase in the level of H2O2 and myeloperoxidase in mouse epidermal tissue.	Tetradecanoylphorbol Acetate	36-39	myeloperoxidase	Mus musculus	74-98
28968695-11	2018	After stimulation in vitro with phorbol 12-myristate 13-acetate and ionomycin, the frequencies of Th22 and IL-22+ CD4+ lymphocytes were similar between patients with and without GCA.	Tetradecanoylphorbol Acetate	32-63	interleukin 22	Homo sapiens	107-112
7590279-5	1995	Phorbol ester (PMA) treatment of cultured baboon SMC produced a 2.5-fold increase in TIMP-1 transcript.	Tetradecanoylphorbol Acetate	15-18	metalloproteinase inhibitor 1	Papio anubis	85-91
29662625-10	2018	Phorbol 12-myristate 13-acetate (PMA), similarly to cisplatin, mediated AREG shedding and membrane fading of surface ADAM17.	Tetradecanoylphorbol Acetate	0-31	amphiregulin	Homo sapiens	72-76
29662625-10	2018	Phorbol 12-myristate 13-acetate (PMA), similarly to cisplatin, mediated AREG shedding and membrane fading of surface ADAM17.	Tetradecanoylphorbol Acetate	0-31	ADAM metallopeptidase domain 17	Homo sapiens	117-123
29662625-10	2018	Phorbol 12-myristate 13-acetate (PMA), similarly to cisplatin, mediated AREG shedding and membrane fading of surface ADAM17.	Tetradecanoylphorbol Acetate	33-36	amphiregulin	Homo sapiens	72-76
29662625-10	2018	Phorbol 12-myristate 13-acetate (PMA), similarly to cisplatin, mediated AREG shedding and membrane fading of surface ADAM17.	Tetradecanoylphorbol Acetate	33-36	ADAM metallopeptidase domain 17	Homo sapiens	117-123
7485466-4	1995	IL-1Ra was produced constitutively in most experiments, and its production was upregulated by phorbol 12-myristate 13-acetate and by IL-1 beta.	Tetradecanoylphorbol Acetate	94-125	interleukin 1 receptor antagonist	Homo sapiens	0-6
29710490-0	2018	Anti-metastatic potential of a proton beam is regulated by p38 MAPK/c-Fos signaling pathway in TPA-treated HepG2 human hepatocellular carcinoma.	Tetradecanoylphorbol Acetate	95-98	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-73
29710490-5	2018	In addition, matrix metalloproteinase-9 (MMP-9) activity and mRNA expressions were reversed by proton beam irradiation in TPA-treated HepG2 cells only.	Tetradecanoylphorbol Acetate	122-125	matrix metallopeptidase 9	Homo sapiens	13-39
29710490-5	2018	In addition, matrix metalloproteinase-9 (MMP-9) activity and mRNA expressions were reversed by proton beam irradiation in TPA-treated HepG2 cells only.	Tetradecanoylphorbol Acetate	122-125	matrix metallopeptidase 9	Homo sapiens	41-46
29710490-8	2018	Therefore, the result demonstrates that the anti-metastatic effects of a proton beam in TPA-treated HepG2 cells are associated with the inhibition of MMP-9 activity and the down-regulations of MMP-9, uPA, uPAR, Snail-1 and VEGF gene expression via the p38 MAPK/c-Fos signaling pathway.	Tetradecanoylphorbol Acetate	88-91	matrix metallopeptidase 9	Homo sapiens	150-155
28589317-0	2017	Bcl6 gene-silencing facilitates PMA-induced megakaryocyte differentiation in K562 cells.	Tetradecanoylphorbol Acetate	32-35	BCL6 transcription repressor	Homo sapiens	0-4
8589290-3	1995	The recovery of pHi per minute (delta pH/min) after an acid load was 0.26 +/- 0.03 (N = 53) in control conditions and was increased by the diadenosine polyphosphates Ap4A, Ap5A, Ap6A, the phorbol ester phorbol 12-myristat 13-acetate (PMA) (each 5 mumol/L) and angiotensin II (100 nmol/L) by 0.05 +/- 0.02 (N = 10), 0.11 +/- 0.05 (N = 13), 0.09 +/- 0.02 (N = 24), 0.10 +/- 0.03 (N = 7), and 0.09 +/- 0.03 (N = 8), respectively.	Tetradecanoylphorbol Acetate	234-237	glucose-6-phosphate isomerase	Rattus norvegicus	16-19
29198314-10	2017	Following 72 h culture of T cells in SMG (SMG-T) or control static (Static-T) conditions, IL-2 production by the T cells was reduced in SMG-T cells compared to Static-T cells upon stimulation by phorbol 12-myristate 13-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	228-231	sterile alpha motif domain containing 4A	Homo sapiens	136-141
29198314-13	2017	When activation of SMG-T cells occurred in SMG, the T cells produced less IL-2 than control T cell cultures upon incubation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	129-132	sterile alpha motif domain containing 4A	Homo sapiens	19-22
29198314-13	2017	When activation of SMG-T cells occurred in SMG, the T cells produced less IL-2 than control T cell cultures upon incubation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	129-132	sterile alpha motif domain containing 4A	Homo sapiens	43-46
29168020-3	2018	A treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced the expression of the Cu transport protein ATP7A in THP-1 cells.	Tetradecanoylphorbol Acetate	17-53	ATPase copper transporting alpha	Homo sapiens	111-116
29168020-3	2018	A treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced the expression of the Cu transport protein ATP7A in THP-1 cells.	Tetradecanoylphorbol Acetate	55-58	ATPase copper transporting alpha	Homo sapiens	111-116
8578682-7	1995	Dot blot analysis indicated that the expression of IL-1 beta was predominant to that of IL-1 alpha in equine PBMC stimulated with LPS or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	137-162	interleukin-1 beta	Equus caballus	51-60
29168020-4	2018	On the other hand, the nuclear translocation of Atox-1 was detected in TPA-treated THP-1 cells, and was suppressed in the presence of the Cu chelator, bathocuproinedisulfonic acid.	Tetradecanoylphorbol Acetate	71-74	antioxidant 1 copper chaperone	Homo sapiens	48-54
29168020-5	2018	Furthermore, Atox-1 bound to the SOD3 promoter region in TPA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	57-60	antioxidant 1 copper chaperone	Homo sapiens	13-19
29168020-6	2018	The overexpression of Atox-1 in THP-1 cells significantly enhanced TPA-elicited SOD3 expression, whereas its knockdown suppressed this induction.	Tetradecanoylphorbol Acetate	67-70	antioxidant 1 copper chaperone	Homo sapiens	22-28
29168020-7	2018	The present results demonstrate that Atox-1 functions as a key molecule in TPA-elicited SOD3 expression.	Tetradecanoylphorbol Acetate	75-78	antioxidant 1 copper chaperone	Homo sapiens	37-43
29115558-8	2018	The activity of ornithine decarboxylase, increased by TPA, was additionally inhibited following pretreatment of the mice with bryostatin 1.	Tetradecanoylphorbol Acetate	54-57	ornithine decarboxylase, structural 1	Mus musculus	16-39
28666872-2	2017	Tumor necrosis factor-alpha converting enzyme (TACE) is known to be responsible for phorbol myristate acetate (PMA)-induced shedding of various membrane proteins.	Tetradecanoylphorbol Acetate	84-109	ADAM metallopeptidase domain 17	Homo sapiens	0-45
28666872-2	2017	Tumor necrosis factor-alpha converting enzyme (TACE) is known to be responsible for phorbol myristate acetate (PMA)-induced shedding of various membrane proteins.	Tetradecanoylphorbol Acetate	84-109	ADAM metallopeptidase domain 17	Homo sapiens	47-51
28666872-2	2017	Tumor necrosis factor-alpha converting enzyme (TACE) is known to be responsible for phorbol myristate acetate (PMA)-induced shedding of various membrane proteins.	Tetradecanoylphorbol Acetate	111-114	ADAM metallopeptidase domain 17	Homo sapiens	0-45
28666872-2	2017	Tumor necrosis factor-alpha converting enzyme (TACE) is known to be responsible for phorbol myristate acetate (PMA)-induced shedding of various membrane proteins.	Tetradecanoylphorbol Acetate	111-114	ADAM metallopeptidase domain 17	Homo sapiens	47-51
28916473-10	2017	We demonstrated that Ser486, a phosphorylation target of ataxia telangiectasia mutated kinase (ATM kinase) located in the NIS of NOX2 (NOX2-NIS), was phosphorylated in purified cytochrome b558 after stimulation with phorbol 12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	216-247	cytochrome b-245 beta chain	Homo sapiens	129-133
7568028-7	1995	As the result of PKR loss, they also showed impaired induction of IFN-alpha and IFN-beta genes in response to several inducers--specifically, encephalomyocarditis virus, lipopolysaccharide, and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	194-225	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	17-20
28916473-10	2017	We demonstrated that Ser486, a phosphorylation target of ataxia telangiectasia mutated kinase (ATM kinase) located in the NIS of NOX2 (NOX2-NIS), was phosphorylated in purified cytochrome b558 after stimulation with phorbol 12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	216-247	cytochrome b-245 beta chain	Homo sapiens	135-139
28916473-10	2017	We demonstrated that Ser486, a phosphorylation target of ataxia telangiectasia mutated kinase (ATM kinase) located in the NIS of NOX2 (NOX2-NIS), was phosphorylated in purified cytochrome b558 after stimulation with phorbol 12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	216-247	mitochondrially encoded cytochrome b	Homo sapiens	177-189
28916473-10	2017	We demonstrated that Ser486, a phosphorylation target of ataxia telangiectasia mutated kinase (ATM kinase) located in the NIS of NOX2 (NOX2-NIS), was phosphorylated in purified cytochrome b558 after stimulation with phorbol 12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	249-252	cytochrome b-245 beta chain	Homo sapiens	129-133
28916473-10	2017	We demonstrated that Ser486, a phosphorylation target of ataxia telangiectasia mutated kinase (ATM kinase) located in the NIS of NOX2 (NOX2-NIS), was phosphorylated in purified cytochrome b558 after stimulation with phorbol 12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	249-252	cytochrome b-245 beta chain	Homo sapiens	135-139
28916473-10	2017	We demonstrated that Ser486, a phosphorylation target of ataxia telangiectasia mutated kinase (ATM kinase) located in the NIS of NOX2 (NOX2-NIS), was phosphorylated in purified cytochrome b558 after stimulation with phorbol 12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	249-252	mitochondrially encoded cytochrome b	Homo sapiens	177-189
28513986-9	2017	TPA also activated Protein Kinase D 1(PKD1) in FFA-exposed cardiomyocytes, as assessed by autophosphorylation of PKD1 on Y916.	Tetradecanoylphorbol Acetate	0-3	protein kinase D1	Homo sapiens	19-35
28594273-0	2017	Effect of TPA and HTLV-1 Tax on BRCA1 and ERE controlled genes expression.	Tetradecanoylphorbol Acetate	10-13	BRCA1 DNA repair associated	Homo sapiens	32-37
7665972-1	1995	We investigated the effects of insulin, insulin-like growth factor-I (IGF-I), and phorbol 12-myristate 13-acetate (PMA) on neutral cholesteryl esterase activity in cultured rat vascular smooth muscle cells.	Tetradecanoylphorbol Acetate	82-113	lipase A, lysosomal acid type	Rattus norvegicus	131-151
28594273-7	2017	Here we examined the effect of TPA on the expression of BRCA1 and genes controlled by ERE region in MCF-7 cells and on Tax activity on these genes.	Tetradecanoylphorbol Acetate	31-34	BRCA1 DNA repair associated	Homo sapiens	56-61
28594273-8	2017	Our results showed strong stimulatory effect of TPA on both BRCA1 and ERE expression without treatment with E2.	Tetradecanoylphorbol Acetate	48-51	BRCA1 DNA repair associated	Homo sapiens	60-65
7665972-1	1995	We investigated the effects of insulin, insulin-like growth factor-I (IGF-I), and phorbol 12-myristate 13-acetate (PMA) on neutral cholesteryl esterase activity in cultured rat vascular smooth muscle cells.	Tetradecanoylphorbol Acetate	115-118	lipase A, lysosomal acid type	Rattus norvegicus	131-151
28594273-10	2017	It seems that TPA activation of BRCA1 and ERE expression is dependent on PKC activity but not through the NFkappaB pathway.	Tetradecanoylphorbol Acetate	14-17	BRCA1 DNA repair associated	Homo sapiens	32-37
28594273-11	2017	However, 53BP1 may be involved in this TPA activity because its overexpression significantly reduced the TPA stimulatory effect on BRCA1 and ERE expression.	Tetradecanoylphorbol Acetate	39-42	BRCA1 DNA repair associated	Homo sapiens	131-136
29166726-8	2017	Post incubation with Calhex231+ TPA, Ro31-8220 and Go6967, TRPC1 and STIM1 positioned in cytoplasm was significantly reduced, and the combined TRPC1 and STIM1 was also significantly reduced.	Tetradecanoylphorbol Acetate	32-35	transient receptor potential cation channel subfamily C member 1	Homo sapiens	59-64
7665972-4	1995	Incubation of cells for 6 to 12 hours with PMA (10(-9) mol/L to 10(-6) mol/L), an activator of protein kinase C, significantly increased neutral cholesteryl esterase activity in a dose-dependent manner.	Tetradecanoylphorbol Acetate	43-46	lipase A, lysosomal acid type	Rattus norvegicus	145-165
28594273-11	2017	However, 53BP1 may be involved in this TPA activity because its overexpression significantly reduced the TPA stimulatory effect on BRCA1 and ERE expression.	Tetradecanoylphorbol Acetate	105-108	BRCA1 DNA repair associated	Homo sapiens	131-136
7665972-5	1995	However, down-regulation of protein kinase C activity by long-term incubation (18 to 48 hours) with PMA resulted in a significant decrease in neutral cholesteryl esterase activity.	Tetradecanoylphorbol Acetate	100-103	lipase A, lysosomal acid type	Rattus norvegicus	150-170
7544583-5	1995	If stimulated with PMA plus ionomycin, JCaM expressed Fas-L mRNA and underwent apoptosis.	Tetradecanoylphorbol Acetate	19-22	Fas ligand	Homo sapiens	54-59
28969043-3	2017	Isothiocyanates, particularly PEITC, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 activity and invasion in various cancer cell lines.	Tetradecanoylphorbol Acetate	48-84	matrix metallopeptidase 9	Homo sapiens	99-104
28969043-3	2017	Isothiocyanates, particularly PEITC, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 activity and invasion in various cancer cell lines.	Tetradecanoylphorbol Acetate	86-89	matrix metallopeptidase 9	Homo sapiens	99-104
28571709-5	2017	Our data show that treatment of cells with phorbol 12-myristate 13-acetate (PMA), amphetamine (AMPH) or okadaic acid (OA) leads to an increase in the phosphorylation of DAT at both residues and that these responses are dependent on the activity of protein kinase C. We also show that AMPH-induced and OA-induced phosphorylation of DAT are dependent on Ca2+/calmodulin-dependent protein kinase alpha.	Tetradecanoylphorbol Acetate	43-74	solute carrier family 6 member 3	Homo sapiens	169-172
28571709-5	2017	Our data show that treatment of cells with phorbol 12-myristate 13-acetate (PMA), amphetamine (AMPH) or okadaic acid (OA) leads to an increase in the phosphorylation of DAT at both residues and that these responses are dependent on the activity of protein kinase C. We also show that AMPH-induced and OA-induced phosphorylation of DAT are dependent on Ca2+/calmodulin-dependent protein kinase alpha.	Tetradecanoylphorbol Acetate	43-74	solute carrier family 6 member 3	Homo sapiens	331-334
28571709-5	2017	Our data show that treatment of cells with phorbol 12-myristate 13-acetate (PMA), amphetamine (AMPH) or okadaic acid (OA) leads to an increase in the phosphorylation of DAT at both residues and that these responses are dependent on the activity of protein kinase C. We also show that AMPH-induced and OA-induced phosphorylation of DAT are dependent on Ca2+/calmodulin-dependent protein kinase alpha.	Tetradecanoylphorbol Acetate	76-79	solute carrier family 6 member 3	Homo sapiens	169-172
28571709-5	2017	Our data show that treatment of cells with phorbol 12-myristate 13-acetate (PMA), amphetamine (AMPH) or okadaic acid (OA) leads to an increase in the phosphorylation of DAT at both residues and that these responses are dependent on the activity of protein kinase C. We also show that AMPH-induced and OA-induced phosphorylation of DAT are dependent on Ca2+/calmodulin-dependent protein kinase alpha.	Tetradecanoylphorbol Acetate	76-79	solute carrier family 6 member 3	Homo sapiens	331-334
27887857-10	2017	In vitro studies demonstrated that the inhibition of DPP-4 promoted PMA-induced monocytic cells differentiation, with increased CD68 and p21 expression, regulated by extracellular signal-regulated protein kinase 1/2 activation.	Tetradecanoylphorbol Acetate	68-71	CD68 molecule	Homo sapiens	128-132
28185006-9	2017	Our data indicated that TPA-induced hair follicle regeneration is associated with activation of Akt and Wnt/beta-catenin signaling.	Tetradecanoylphorbol Acetate	24-27	catenin (cadherin associated protein), beta 1	Mus musculus	108-120
7605983-5	1995	Furthermore, PDTC inhibited TF expression in response to tumor necrosis factor-alpha, interleukin-1 beta, and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	110-141	coagulation factor III, tissue factor	Homo sapiens	28-30
28970848-10	2017	CONCLUSION: The results indicated that the inhibitory effects of CFE against TPA-induced MMP-9 expression and MCF-7 cell invasion were dependent on the protein kinase C delta/p38/c-Jun N-terminal kinase/AP-1 pathway.	Tetradecanoylphorbol Acetate	77-80	matrix metallopeptidase 9	Homo sapiens	89-94
28970848-10	2017	CONCLUSION: The results indicated that the inhibitory effects of CFE against TPA-induced MMP-9 expression and MCF-7 cell invasion were dependent on the protein kinase C delta/p38/c-Jun N-terminal kinase/AP-1 pathway.	Tetradecanoylphorbol Acetate	77-80	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	203-207
7605990-6	1995	PEBP2 alpha A1 and alpha B1 enhanced the expression of the GM-CSF promoter-driven reporter plasmid in unstimulated and 12-O-tetradecanoylphorbol 13-acetate/phytohemagglutinin-stimulated human Jurkat T cells.	Tetradecanoylphorbol Acetate	119-155	phosphatidylethanolamine binding protein 2	Mus musculus	0-5
7605990-6	1995	PEBP2 alpha A1 and alpha B1 enhanced the expression of the GM-CSF promoter-driven reporter plasmid in unstimulated and 12-O-tetradecanoylphorbol 13-acetate/phytohemagglutinin-stimulated human Jurkat T cells.	Tetradecanoylphorbol Acetate	119-155	colony stimulating factor 2	Homo sapiens	59-65
7795258-4	1995	Downregulation of protein kinase (PK) by a 24-hour incubation in 100 nmol/L 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in the presence of IL-3 dramatically reduced bcl-2 mRNA levels, and induced apoptosis in the presence of IL-3.	Tetradecanoylphorbol Acetate	76-113	interleukin 3	Homo sapiens	139-143
28408066-1	2017	BACKGROUND AND PURPOSE: As Chinese Asian populations have an increased risk of intracerebral hemorrhage (ICH) after intravenous tissue plasminogen activator (IV tPA), we aimed to design a rapid, clinically applicable risk scoring system to predict ICH and functional outcomes after IV tPA treatment in Asian ischemic stroke patients.	Tetradecanoylphorbol Acetate	161-164	chromosome 20 open reading frame 181	Homo sapiens	128-156
28179525-8	2017	We show that LMP1 enhances the lytic infection-inducing effects of epithelial cell differentiation, as well as 12-O-tetradecanoylphorbol-13-acetate (TPA) and sodium butyrate treatment, in EBV-infected epithelial cells by increasing expression of the Z and R proteins.	Tetradecanoylphorbol Acetate	111-147	PDZ and LIM domain 7	Homo sapiens	13-17
7795258-4	1995	Downregulation of protein kinase (PK) by a 24-hour incubation in 100 nmol/L 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in the presence of IL-3 dramatically reduced bcl-2 mRNA levels, and induced apoptosis in the presence of IL-3.	Tetradecanoylphorbol Acetate	76-113	interleukin 3	Homo sapiens	225-229
28097492-9	2017	TRPM2 and TRPV1 currents were increased by the PKC activator, phorbol myristate acetate (PMA), although the currents were decreased by ACA, CPZ, and the PKC inhibitor, bisindolylmaleimide I (BIM).	Tetradecanoylphorbol Acetate	62-87	protein kinase C, gamma	Rattus norvegicus	47-50
28539358-7	2017	Phorbol 12-myristate 13-acetate stimulation of both cell types revealed that PKCepsilon positively regulates beta-catenin expression and stabilization in a glycogen synthase kinase 3beta-independent manner.	Tetradecanoylphorbol Acetate	0-31	catenin (cadherin associated protein), beta 1	Mus musculus	109-121
7795258-4	1995	Downregulation of protein kinase (PK) by a 24-hour incubation in 100 nmol/L 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in the presence of IL-3 dramatically reduced bcl-2 mRNA levels, and induced apoptosis in the presence of IL-3.	Tetradecanoylphorbol Acetate	115-118	interleukin 3	Homo sapiens	139-143
7795258-4	1995	Downregulation of protein kinase (PK) by a 24-hour incubation in 100 nmol/L 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in the presence of IL-3 dramatically reduced bcl-2 mRNA levels, and induced apoptosis in the presence of IL-3.	Tetradecanoylphorbol Acetate	115-118	interleukin 3	Homo sapiens	225-229
7789317-8	1995	Both insulin and TPA stimulated egr-1 gene expression up to 10-fold in the control cell, but neither of these two agents showed any effect on egr-1 gene expression in the PKC-alpha down-regulated Hep3B cells.	Tetradecanoylphorbol Acetate	17-20	early growth response 1	Homo sapiens	32-37
29050234-9	2017	Via its interaction with IkappaBalpha, AURKC indirectly induced NF-kappaB activation; accordingly, AKCI decreased PMA-induced activation of NF-kappaB.	Tetradecanoylphorbol Acetate	114-117	aurora kinase C	Homo sapiens	39-44
27930810-11	2017	In vitro, preincubation with alamandine dose-dependently abrogated PMA-induced neutrophil degranulation of MMP-9 and MPO.	Tetradecanoylphorbol Acetate	67-70	myeloperoxidase	Mus musculus	117-120
27810232-0	2017	Potential role of IL-17-producing CD4/CD8 double negative alphabeta T cells in psoriatic skin inflammation in a TPA-induced STAT3C transgenic mouse model.	Tetradecanoylphorbol Acetate	112-115	interleukin 17A	Mus musculus	18-23
27810232-4	2017	OBJECTIVE: To investigate which subsets of IL-17-producing cells are involved in psoriasis-like skin inflammation in a TPA (tumor promoter 12-O-tetradecanoylphorbol-13-acetate)-induced K14.Stat3C mouse model.	Tetradecanoylphorbol Acetate	119-122	interleukin 17A	Mus musculus	43-48
27810232-4	2017	OBJECTIVE: To investigate which subsets of IL-17-producing cells are involved in psoriasis-like skin inflammation in a TPA (tumor promoter 12-O-tetradecanoylphorbol-13-acetate)-induced K14.Stat3C mouse model.	Tetradecanoylphorbol Acetate	139-175	interleukin 17A	Mus musculus	43-48
28402957-5	2017	Furthermore, we notice that a series of genes, including PI3KCA, NFATC1and TNFSF9, which play important roles during NK cell activation, were at "poised" state prior to activation, and that modifications of H3K4me3 and H3K27me3 on these promotors were sensitive to stimulation with Phorbol Myristate Acetate (PMA) and Ionomycin (Iono) in the NK92MI cell line.	Tetradecanoylphorbol Acetate	309-312	nuclear factor of activated T cells 1	Homo sapiens	65-71
7628547-3	1995	In senescent endothelial cells, PAI-1 mRNA and protein are constitutively high, but uninducible by exogenous interleukin 1 alpha as well as by the phorbol ester TPA.	Tetradecanoylphorbol Acetate	161-164	serpin family E member 1	Homo sapiens	32-37
28380444-4	2017	Exposure of human nasopharyngeal carcinoma (NPC) cells to phorbol-12-myristate-13-acetate (PMA) increased the levels of Casp12 and MMP-9 resulting in NPC cell invasion.	Tetradecanoylphorbol Acetate	58-89	caspase 12 (gene/pseudogene)	Homo sapiens	120-126
27810232-6	2017	RESULTS: We observed significantly increased numbers of IL-17-producing CD4+ T cells, CD8+ T cells and dermal gammadelta T cells in TPA-induced skin lesions of K14.Stat3C mice.	Tetradecanoylphorbol Acetate	132-135	interleukin 17A	Mus musculus	56-61
27810232-6	2017	RESULTS: We observed significantly increased numbers of IL-17-producing CD4+ T cells, CD8+ T cells and dermal gammadelta T cells in TPA-induced skin lesions of K14.Stat3C mice.	Tetradecanoylphorbol Acetate	132-135	CD8a molecule	Homo sapiens	86-89
27810232-11	2017	CONCLUSION: In TPA-induced lesional skin of K14.Stat3C mice, IL-17-producing CD4+ Th17 cells, CD8+ Tc17 cells, dermal gammadelta T cells and TCR- cells probably containing ILCs all participated in skin inflammation, which is similar to human clinical psoriatic features.	Tetradecanoylphorbol Acetate	15-18	interleukin 17A	Mus musculus	61-66
27810232-11	2017	CONCLUSION: In TPA-induced lesional skin of K14.Stat3C mice, IL-17-producing CD4+ Th17 cells, CD8+ Tc17 cells, dermal gammadelta T cells and TCR- cells probably containing ILCs all participated in skin inflammation, which is similar to human clinical psoriatic features.	Tetradecanoylphorbol Acetate	15-18	CD4 antigen	Mus musculus	77-80
28380444-4	2017	Exposure of human nasopharyngeal carcinoma (NPC) cells to phorbol-12-myristate-13-acetate (PMA) increased the levels of Casp12 and MMP-9 resulting in NPC cell invasion.	Tetradecanoylphorbol Acetate	58-89	matrix metallopeptidase 9	Homo sapiens	131-136
28380444-4	2017	Exposure of human nasopharyngeal carcinoma (NPC) cells to phorbol-12-myristate-13-acetate (PMA) increased the levels of Casp12 and MMP-9 resulting in NPC cell invasion.	Tetradecanoylphorbol Acetate	91-94	caspase 12 (gene/pseudogene)	Homo sapiens	120-126
28380444-4	2017	Exposure of human nasopharyngeal carcinoma (NPC) cells to phorbol-12-myristate-13-acetate (PMA) increased the levels of Casp12 and MMP-9 resulting in NPC cell invasion.	Tetradecanoylphorbol Acetate	91-94	matrix metallopeptidase 9	Homo sapiens	131-136
7564571-2	1995	To elucidate this, we investigated the capacity of AM from young (16-week-old) and aged (100-week-old) rats to become primed with recombinant rat interferon-gamma (IFN-gamma) for increased phorbol myristate acetate (PMA)-elicited O2- production, utilizing an MCLA-dependent chemiluminescent assay.	Tetradecanoylphorbol Acetate	189-214	interferon gamma	Rattus norvegicus	146-162
28469194-5	2017	KXS might fulfill this effect by up-regulating the expressions of NGF, BDNF and Trk receptors in hippocampus, which were confirmed by the treatment of corresponding blockers tPA-stop and K252a.	Tetradecanoylphorbol Acetate	174-177	nerve growth factor	Mus musculus	66-69
7564571-2	1995	To elucidate this, we investigated the capacity of AM from young (16-week-old) and aged (100-week-old) rats to become primed with recombinant rat interferon-gamma (IFN-gamma) for increased phorbol myristate acetate (PMA)-elicited O2- production, utilizing an MCLA-dependent chemiluminescent assay.	Tetradecanoylphorbol Acetate	189-214	interferon gamma	Rattus norvegicus	164-173
27267660-4	2016	Directly activating protein kinase Cs with phorbol myristate acetate stimulated microglial phagocytosis, and induced neuronal loss mediated by MFG-E8/vitronectin receptor pathway of microglial phagocytosis.	Tetradecanoylphorbol Acetate	43-68	vitronectin	Homo sapiens	150-161
7775485-1	1995	Selective 12-O-tetradecanoylphorbol-13-acetate induction of a single transcription start site in the HMG-I/Y gene.	Tetradecanoylphorbol Acetate	10-46	high mobility group AT-hook 1	Homo sapiens	101-108
27809835-10	2016	Moreover, Anv-polysaccharides strongly inhibited PMA-induced PKCbeta and p47phox translocation to membranes and p47phox phosphorylation on Ser328, a main PKC target.	Tetradecanoylphorbol Acetate	49-52	neutrophil cytosolic factor 1	Homo sapiens	73-80
28502291-4	2017	Results IM significantly inhibited both mRNA and protein levels of ABIN1 and NF-kappaB, but raised the mRNA and protein levels of A20; while phorbol 12-myristate 13-acetate/ionomycin increased the expression levels of ABIN1 and A20 mRNA and protein.	Tetradecanoylphorbol Acetate	141-172	immunoglobulin kappa variable 1-27	Homo sapiens	228-231
27809835-10	2016	Moreover, Anv-polysaccharides strongly inhibited PMA-induced PKCbeta and p47phox translocation to membranes and p47phox phosphorylation on Ser328, a main PKC target.	Tetradecanoylphorbol Acetate	49-52	neutrophil cytosolic factor 1	Homo sapiens	112-119
7775485-2	1995	The human HMG-I/Y gene, encoding the non-histone "high mobility group" proteins HMG-I and HMG-Y, is transcriptionally activated in human K562 erythroleukemia cells by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	182-218	high mobility group AT-hook 1	Homo sapiens	10-17
7775485-2	1995	The human HMG-I/Y gene, encoding the non-histone "high mobility group" proteins HMG-I and HMG-Y, is transcriptionally activated in human K562 erythroleukemia cells by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	220-223	high mobility group AT-hook 1	Homo sapiens	10-17
28301720-3	2017	Herein, we demonstrated a terrylenediimide (TDI)-poly(acrylic acid) (TPA)-based nanomedicine (TNM) platform used as an intrinsic theranostic agent.	Tetradecanoylphorbol Acetate	69-72	teneurin transmembrane protein 1	Homo sapiens	94-97
7775485-4	1995	In this report, we show that transcriptional activation of the HMG-I/Y gene is dependent on protein synthesis and is an early event (2 h after induction) in the TPA-mediated differentiation process.	Tetradecanoylphorbol Acetate	161-164	high mobility group AT-hook 1	Homo sapiens	63-70
7775602-4	1995	12-O-Tetradecanoylphorbol-13-acetate (TPA) or linoleic acid decreased tyrosinase activity, while dibutyryl cyclic adenosine monophosphate (dbcAMP) or palmitic acid increased it.	Tetradecanoylphorbol Acetate	0-36	tyrosinase	Mus musculus	70-80
27600920-0	2016	Melatonin suppresses TPA-induced metastasis by downregulating matrix metalloproteinase-9 expression through JNK/SP-1 signaling in nasopharyngeal carcinoma.	Tetradecanoylphorbol Acetate	21-24	matrix metallopeptidase 9	Homo sapiens	62-88
27600920-4	2016	Here, we show that melatonin treatment inhibits TPA-induced cell motility by regulating the matrix metalloproteinase-9 (MMP-9) expression in NPC.	Tetradecanoylphorbol Acetate	48-51	matrix metallopeptidase 9	Homo sapiens	92-118
27600920-4	2016	Here, we show that melatonin treatment inhibits TPA-induced cell motility by regulating the matrix metalloproteinase-9 (MMP-9) expression in NPC.	Tetradecanoylphorbol Acetate	48-51	matrix metallopeptidase 9	Homo sapiens	120-125
27923483-10	2017	Treatment with PMA induced MT1-MMP-GFP internalization, enhanced phospho-Smad2, and reduced MMP-2 activation, whereas rottlerin pretreatment inhibited these effects.	Tetradecanoylphorbol Acetate	15-18	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	27-34
27923483-10	2017	Treatment with PMA induced MT1-MMP-GFP internalization, enhanced phospho-Smad2, and reduced MMP-2 activation, whereas rottlerin pretreatment inhibited these effects.	Tetradecanoylphorbol Acetate	15-18	matrix metallopeptidase 2	Mus musculus	92-97
27600920-8	2016	Thus, we conclude that melatonin suppresses the motility of NPC by regulating TPA-induced MMP-9 gene expression via inhibiting SP-1-DNA binding ability.	Tetradecanoylphorbol Acetate	78-81	matrix metallopeptidase 9	Homo sapiens	90-95
7775602-4	1995	12-O-Tetradecanoylphorbol-13-acetate (TPA) or linoleic acid decreased tyrosinase activity, while dibutyryl cyclic adenosine monophosphate (dbcAMP) or palmitic acid increased it.	Tetradecanoylphorbol Acetate	38-41	tyrosinase	Mus musculus	70-80
7775602-6	1995	The number of melanosomes changed when agents which modulate the tyrosinase gene expression were added, since TPA decreased, dbcAMP increased, and linoleic acid or palmitic acid did not alter their number.	Tetradecanoylphorbol Acetate	110-113	tyrosinase	Mus musculus	65-75
7761434-8	1995	Furthermore, Fra-1 repressed AP-1 activity induced by either TPA or expression of c-Jun and c-Fos.	Tetradecanoylphorbol Acetate	61-64	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	13-18
27737648-3	2016	METHODS AND RESULTS: Exposure of NPC cells to phorbol-12-myristate-13-acetate (PMA) or macrophage conditioned media (CM) upregulated MMP-9 and N-cadherin cleavage, which resulted in NPC cell invasion.	Tetradecanoylphorbol Acetate	46-77	matrix metallopeptidase 9	Homo sapiens	133-138
27737648-3	2016	METHODS AND RESULTS: Exposure of NPC cells to phorbol-12-myristate-13-acetate (PMA) or macrophage conditioned media (CM) upregulated MMP-9 and N-cadherin cleavage, which resulted in NPC cell invasion.	Tetradecanoylphorbol Acetate	46-77	cadherin 2	Homo sapiens	143-153
28098879-9	2017	PMA potently stimulated MMP-9 and had a moderate effect on MMP-2.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	24-29
28286738-4	2017	Treatment with phorbol-12-myristate-13-acetate (PMA), a potent agonist of protein kinase C (PKC) and its downstream effector in the MEK/ERK-dependent pathway, resulted in the activation of mTORC1 signaling and phosphorylation of the upstream regulator tuberous sclerosis 2 (TSC2) in C2C12 myoblasts.	Tetradecanoylphorbol Acetate	15-46	TSC complex subunit 2	Homo sapiens	274-278
28286738-4	2017	Treatment with phorbol-12-myristate-13-acetate (PMA), a potent agonist of protein kinase C (PKC) and its downstream effector in the MEK/ERK-dependent pathway, resulted in the activation of mTORC1 signaling and phosphorylation of the upstream regulator tuberous sclerosis 2 (TSC2) in C2C12 myoblasts.	Tetradecanoylphorbol Acetate	48-51	TSC complex subunit 2	Homo sapiens	274-278
28286738-6	2017	TSC2 phosphorylation at Ser664 (an ERK-dependent phosphorylation site) was prevented with U0126, and BIM-I treatment blocked PMA-induced phosphorylation of TSC2 at multiple residues (Ser664, Ser939, and Thr1462).	Tetradecanoylphorbol Acetate	125-128	TSC complex subunit 2	Homo sapiens	0-4
28286738-6	2017	TSC2 phosphorylation at Ser664 (an ERK-dependent phosphorylation site) was prevented with U0126, and BIM-I treatment blocked PMA-induced phosphorylation of TSC2 at multiple residues (Ser664, Ser939, and Thr1462).	Tetradecanoylphorbol Acetate	125-128	TSC complex subunit 2	Homo sapiens	156-160
27737648-3	2016	METHODS AND RESULTS: Exposure of NPC cells to phorbol-12-myristate-13-acetate (PMA) or macrophage conditioned media (CM) upregulated MMP-9 and N-cadherin cleavage, which resulted in NPC cell invasion.	Tetradecanoylphorbol Acetate	79-82	matrix metallopeptidase 9	Homo sapiens	133-138
27737648-3	2016	METHODS AND RESULTS: Exposure of NPC cells to phorbol-12-myristate-13-acetate (PMA) or macrophage conditioned media (CM) upregulated MMP-9 and N-cadherin cleavage, which resulted in NPC cell invasion.	Tetradecanoylphorbol Acetate	79-82	cadherin 2	Homo sapiens	143-153
7761434-9	1995	We therefore conclude that inhibitory AP-1 complexes composed of Jun-Fra heterodimers, induced by BHQ, antagonize the transcriptional effects of the tumor promoter TPA, which are mediated by Jun-Fos heterodimers.	Tetradecanoylphorbol Acetate	164-167	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	69-72
7537734-7	1995	PKC down-regulation following prolonged exposure to TPA diminished TPA-stimulated RPTP alpha phosphorylation.	Tetradecanoylphorbol Acetate	52-55	protein tyrosine phosphatase, receptor type, A	Mus musculus	82-92
27737648-6	2016	CTF2/N-cad (CTF2), a product of the gamma-secretase cleavage of N-cadherin, was released and translocated into the nuclear compartment in PMA-treated cells.	Tetradecanoylphorbol Acetate	138-141	cadherin 2	Homo sapiens	5-10
27737648-6	2016	CTF2/N-cad (CTF2), a product of the gamma-secretase cleavage of N-cadherin, was released and translocated into the nuclear compartment in PMA-treated cells.	Tetradecanoylphorbol Acetate	138-141	cadherin 2	Homo sapiens	64-74
27876502-3	2017	MATERIALS AND METHODS: MeOH extracts (MOD) and BuOH extracts (BOD) were prepared and examined for their ability to inhibit phorbol myristate acetate (PMA)-induced matrix metalloproteinase (MMP)-9 and intercellular adhesion molecule (ICAM)-1 expressions in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	123-148	matrix metallopeptidase 9	Homo sapiens	163-195
27876502-3	2017	MATERIALS AND METHODS: MeOH extracts (MOD) and BuOH extracts (BOD) were prepared and examined for their ability to inhibit phorbol myristate acetate (PMA)-induced matrix metalloproteinase (MMP)-9 and intercellular adhesion molecule (ICAM)-1 expressions in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	150-153	matrix metallopeptidase 9	Homo sapiens	163-195
7537734-7	1995	PKC down-regulation following prolonged exposure to TPA diminished TPA-stimulated RPTP alpha phosphorylation.	Tetradecanoylphorbol Acetate	67-70	protein tyrosine phosphatase, receptor type, A	Mus musculus	82-92
27708396-3	2016	Here, we demonstrate that ERK/c-Jun signaling is involved in DNA demethylation of EBV immediate early (IE) gene Zta in response to 12-O-Tetradecanoylphorbol-13-acetate (TPA) stimulation.	Tetradecanoylphorbol Acetate	131-167	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-35
7537734-10	1995	TPA treatment caused redistribution of some intracellular RPTP alpha to the cell surface, but this did not require direct phosphorylation of RPTP alpha at Ser-180/Ser-204.	Tetradecanoylphorbol Acetate	0-3	protein tyrosine phosphatase, receptor type, A	Mus musculus	58-68
27708396-3	2016	Here, we demonstrate that ERK/c-Jun signaling is involved in DNA demethylation of EBV immediate early (IE) gene Zta in response to 12-O-Tetradecanoylphorbol-13-acetate (TPA) stimulation.	Tetradecanoylphorbol Acetate	169-172	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-35
27708396-8	2016	Thus, TPA activates ERK/c-Jun signaling, which subsequently facilitates Tet1 to bind to Zta promoter, leading to DNA demethylation, gene expression, and EBV reactivation.	Tetradecanoylphorbol Acetate	6-9	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	24-29
7648800-2	1995	Lucigenin-enhanced chemiluminescence (CL) to phorbol myristate acetate as respiratory burst and sorbitol levels in neutrophils after incubation with glucose and an aldose reductase (AR) inhibitor, SNK-860 (SNK) were measured.	Tetradecanoylphorbol Acetate	45-70	polo like kinase 2	Homo sapiens	197-204
27580455-4	2016	Interestingly, in vivo assays of ECGO topical treatment (100mug/20mul/ear) significantly mitigated the TPA (4mug/20mul/ear) induced edema induction and Myeloperoxidase activity.	Tetradecanoylphorbol Acetate	103-106	myeloperoxidase	Mus musculus	152-167
29358849-8	2017	In addition, overexpression of Mfn2 downregulated phorbol myristate acetate (PMA)/ionomycin-, rapamycin- and starvation-induced autophagy in Jurkat T cells.	Tetradecanoylphorbol Acetate	50-75	mitofusin 2	Homo sapiens	31-35
29358849-8	2017	In addition, overexpression of Mfn2 downregulated phorbol myristate acetate (PMA)/ionomycin-, rapamycin- and starvation-induced autophagy in Jurkat T cells.	Tetradecanoylphorbol Acetate	77-80	mitofusin 2	Homo sapiens	31-35
27693558-3	2016	Here, we report that mice deficient for Lgr4 are resistant to 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced keratinocyte proliferation and papilloma formation.	Tetradecanoylphorbol Acetate	62-99	leucine-rich repeat-containing G protein-coupled receptor 4	Mus musculus	40-44
27693558-3	2016	Here, we report that mice deficient for Lgr4 are resistant to 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced keratinocyte proliferation and papilloma formation.	Tetradecanoylphorbol Acetate	101-104	leucine-rich repeat-containing G protein-coupled receptor 4	Mus musculus	40-44
7648800-2	1995	Lucigenin-enhanced chemiluminescence (CL) to phorbol myristate acetate as respiratory burst and sorbitol levels in neutrophils after incubation with glucose and an aldose reductase (AR) inhibitor, SNK-860 (SNK) were measured.	Tetradecanoylphorbol Acetate	45-70	polo like kinase 2	Homo sapiens	197-200
27693558-4	2016	We show that TPA treatment activates MEK1, ERK1/2 and downstream effector AP-1 in wild-type (WT) epidermal cells and mice, but not in cells or mice where Lgr4 is depleted.	Tetradecanoylphorbol Acetate	13-16	leucine-rich repeat-containing G protein-coupled receptor 4	Mus musculus	154-158
27693558-5	2016	Wnt/beta-catenin signaling is also dramatically activated by TPA treatment, and this activation is abolished when Lgr4 is deleted.	Tetradecanoylphorbol Acetate	61-64	catenin (cadherin associated protein), beta 1	Mus musculus	4-16
12595919-10	1995	BCP in acetone was tested as an initiator with the promoter 12- O -tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	60-98	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	Mus musculus	0-3
27693558-5	2016	Wnt/beta-catenin signaling is also dramatically activated by TPA treatment, and this activation is abolished when Lgr4 is deleted.	Tetradecanoylphorbol Acetate	61-64	leucine-rich repeat-containing G protein-coupled receptor 4	Mus musculus	114-118
27693558-6	2016	We provide evidences that blocking both MEK1/ERK1/2 and Wnt/beta-catenin pathways prevents TPA-induced increase in the expression of Ccnd1 (cyclin D1), a known Wnt/beta-catenin target gene, and that the activation of MEK1/ERK1/2 pathway lies upstream of Wnt/beta-catenin signal pathway.	Tetradecanoylphorbol Acetate	91-94	catenin (cadherin associated protein), beta 1	Mus musculus	60-72
27693558-6	2016	We provide evidences that blocking both MEK1/ERK1/2 and Wnt/beta-catenin pathways prevents TPA-induced increase in the expression of Ccnd1 (cyclin D1), a known Wnt/beta-catenin target gene, and that the activation of MEK1/ERK1/2 pathway lies upstream of Wnt/beta-catenin signal pathway.	Tetradecanoylphorbol Acetate	91-94	cyclin D1	Mus musculus	133-138
27693558-6	2016	We provide evidences that blocking both MEK1/ERK1/2 and Wnt/beta-catenin pathways prevents TPA-induced increase in the expression of Ccnd1 (cyclin D1), a known Wnt/beta-catenin target gene, and that the activation of MEK1/ERK1/2 pathway lies upstream of Wnt/beta-catenin signal pathway.	Tetradecanoylphorbol Acetate	91-94	cyclin D1	Mus musculus	140-149
27693558-6	2016	We provide evidences that blocking both MEK1/ERK1/2 and Wnt/beta-catenin pathways prevents TPA-induced increase in the expression of Ccnd1 (cyclin D1), a known Wnt/beta-catenin target gene, and that the activation of MEK1/ERK1/2 pathway lies upstream of Wnt/beta-catenin signal pathway.	Tetradecanoylphorbol Acetate	91-94	catenin (cadherin associated protein), beta 1	Mus musculus	164-176
27693558-6	2016	We provide evidences that blocking both MEK1/ERK1/2 and Wnt/beta-catenin pathways prevents TPA-induced increase in the expression of Ccnd1 (cyclin D1), a known Wnt/beta-catenin target gene, and that the activation of MEK1/ERK1/2 pathway lies upstream of Wnt/beta-catenin signal pathway.	Tetradecanoylphorbol Acetate	91-94	catenin (cadherin associated protein), beta 1	Mus musculus	164-176
26868487-4	2016	Functional analysis of ZEB1 phosphorylation site mutants near the second zinc finger domain (termed ZD2) show that increased phosphorylation (due to either PMA plus ionomycin, or IGF-1) can inhibit transcriptional repression by either a ZEB1-ZD2 domain clone, or full-length ZEB1.	Tetradecanoylphorbol Acetate	156-159	zinc finger E-box binding homeobox 1	Homo sapiens	23-27
26868487-4	2016	Functional analysis of ZEB1 phosphorylation site mutants near the second zinc finger domain (termed ZD2) show that increased phosphorylation (due to either PMA plus ionomycin, or IGF-1) can inhibit transcriptional repression by either a ZEB1-ZD2 domain clone, or full-length ZEB1.	Tetradecanoylphorbol Acetate	156-159	zinc finger E-box binding homeobox 1	Homo sapiens	237-241
26868487-4	2016	Functional analysis of ZEB1 phosphorylation site mutants near the second zinc finger domain (termed ZD2) show that increased phosphorylation (due to either PMA plus ionomycin, or IGF-1) can inhibit transcriptional repression by either a ZEB1-ZD2 domain clone, or full-length ZEB1.	Tetradecanoylphorbol Acetate	156-159	zinc finger E-box binding homeobox 1	Homo sapiens	237-241
12595919-10	1995	BCP in acetone was tested as an initiator with the promoter 12- O -tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	100-103	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	Mus musculus	0-3
7718627-6	1995	Both genes were also inducible by TPA while forskolin which activates the cAMP-dependent pathway induced TIS1 but not TIS8.	Tetradecanoylphorbol Acetate	34-37	nuclear receptor subfamily 4, group A, member 1	Mus musculus	105-109
27349859-4	2016	BK5.PRAS40(T246A) mice were resistant to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced epidermal hyperproliferation and skin tumor development.	Tetradecanoylphorbol Acetate	41-77	AKT1 substrate 1 (proline-rich)	Mus musculus	4-10
27349859-4	2016	BK5.PRAS40(T246A) mice were resistant to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced epidermal hyperproliferation and skin tumor development.	Tetradecanoylphorbol Acetate	79-82	AKT1 substrate 1 (proline-rich)	Mus musculus	4-10
27349859-5	2016	In transgenic mice, PRAS40(T246A) remained bound to raptor in keratinocytes even after treatment with TPA, consistent with reduced mTORC1 signaling and altered levels of cell cycle proteins.	Tetradecanoylphorbol Acetate	102-105	AKT1 substrate 1 (proline-rich)	Mus musculus	20-26
27707928-9	2016	Consistent with this, the majority of these CD8 T cells remained IFN-gamma unresponsive even after TCR-dependent polyclonal stimulation (anti-CD3 plus anti-CD28) but produced IFN-gamma by TCR-independent polyclonal stimulation (phorbol 12-myristate 13-acetate [PMA] plus ionomycin).	Tetradecanoylphorbol Acetate	228-259	CD8a molecule	Homo sapiens	44-47
27707928-9	2016	Consistent with this, the majority of these CD8 T cells remained IFN-gamma unresponsive even after TCR-dependent polyclonal stimulation (anti-CD3 plus anti-CD28) but produced IFN-gamma by TCR-independent polyclonal stimulation (phorbol 12-myristate 13-acetate [PMA] plus ionomycin).	Tetradecanoylphorbol Acetate	261-264	CD8a molecule	Homo sapiens	44-47
27349859-6	2016	BK5.PRAS40(T246A) mice also displayed attenuated skin inflammation in response to TPA.	Tetradecanoylphorbol Acetate	82-85	AKT1 substrate 1 (proline-rich)	Mus musculus	4-10
7718627-7	1995	Down-regulation of protein kinase C (PKC) activity by TPA pretreatment repressed the bFGF induction of TIS1 but had little effect on the bFGF-stimulated expression of TIS8.	Tetradecanoylphorbol Acetate	54-57	nuclear receptor subfamily 4, group A, member 1	Mus musculus	103-107
27942049-8	2016	Moreover, in HEK cells expressing KLHL3 and WNK4, we showed that the activation of protein kinase C by phorbol 12-myristate 13-acetate induces KLHL3S433-P and increases WNK4 levels by abrogating its ubiquitination.	Tetradecanoylphorbol Acetate	103-134	kelch-like 3	Mus musculus	34-39
7717978-5	1995	The tumour promoter and protein kinase C agonist, phorbol 12-myristate 13-acetate (PMA), also activated Raf-1, MEK-1, and MAP kinase in Ramos cells, but did not induce tyrosine phosphorylation of Shc or Shc/Grb2 association.	Tetradecanoylphorbol Acetate	50-81	mitogen-activated protein kinase kinase 1	Homo sapiens	111-116
27464529-0	2016	12-O-tetradecanoylphorbol-13-acetate activates hair follicle melanocytes for hair pigmentation via Wnt/beta-catenin signaling.	Tetradecanoylphorbol Acetate	0-36	catenin (cadherin associated protein), beta 1	Mus musculus	103-115
7717978-5	1995	The tumour promoter and protein kinase C agonist, phorbol 12-myristate 13-acetate (PMA), also activated Raf-1, MEK-1, and MAP kinase in Ramos cells, but did not induce tyrosine phosphorylation of Shc or Shc/Grb2 association.	Tetradecanoylphorbol Acetate	83-86	mitogen-activated protein kinase kinase 1	Homo sapiens	111-116
27464529-8	2016	At the molecular level, nuclear beta-catenin, a key factor of Wnt/beta-catenin signaling, was highly synthesized in melanocytes and keratinocytes in TPA-induced hair bulbs.	Tetradecanoylphorbol Acetate	149-152	catenin (cadherin associated protein), beta 1	Mus musculus	32-44
27118510-2	2016	When intravenous tissue plasminogen activator (IV-tPA) therapy is considered for acute ischemic stroke, TAAAD must be excluded.	Tetradecanoylphorbol Acetate	50-53	chromosome 20 open reading frame 181	Homo sapiens	17-45
27464529-8	2016	At the molecular level, nuclear beta-catenin, a key factor of Wnt/beta-catenin signaling, was highly synthesized in melanocytes and keratinocytes in TPA-induced hair bulbs.	Tetradecanoylphorbol Acetate	149-152	catenin (cadherin associated protein), beta 1	Mus musculus	66-78
7890653-11	1995	The identical fluorescence changes obtained with tPa.PAI-1 and uPA.PAI-1 complexes and elastase-cleaved PAI-1 strongly suggest that in the stable protease-PAI-1 complex the reactive center loop is cleaved and inserted into beta sheet A and that this process is central to the inhibition mechanism.	Tetradecanoylphorbol Acetate	49-52	serpin family E member 1	Homo sapiens	53-58
27464529-9	2016	Inhibition of Wnt/beta-catenin signaling by injecting Dickkopf1 plasmids into TPA-treated skin decreased hair matrix pigmentation and inhibited the proliferation and differentiation of McSCs.	Tetradecanoylphorbol Acetate	78-81	catenin (cadherin associated protein), beta 1	Mus musculus	18-30
26945879-0	2016	Loss of CRABP-II Characterizes Human Skin Poorly Differentiated Squamous Cell Carcinomas and Favors DMBA/TPA-Induced Carcinogenesis.	Tetradecanoylphorbol Acetate	105-108	cellular retinoic acid binding protein 2	Homo sapiens	8-16
7612191-6	1995	PMA-induced differentiation of myeloid cells is accompanied by inhibition of uPA-PAI-1 internalization/degradation and the down-regulation of alpha 2-MR.	Tetradecanoylphorbol Acetate	0-3	serpin family E member 1	Homo sapiens	81-86
26013710-6	2016	These mice also exhibited significantly reduced epidermal proliferation in response to TPA treatment that again correlated with reduced levels of cell cycle regulators and increased levels of p53 and p21.	Tetradecanoylphorbol Acetate	87-90	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	200-203
27596969-7	2016	Interestingly, immunohistochemistry and flow cytometry analyses revealed that TPA treatment significantly increased infiltration of interleukin-17 (IL-17) producing dermal gammadelta T cells, while frequencies of gammadelta T cells was decreased by GF2 treatment, subsequently ameliorating inflammation in skin.	Tetradecanoylphorbol Acetate	78-81	interleukin 17A	Mus musculus	132-146
27596969-7	2016	Interestingly, immunohistochemistry and flow cytometry analyses revealed that TPA treatment significantly increased infiltration of interleukin-17 (IL-17) producing dermal gammadelta T cells, while frequencies of gammadelta T cells was decreased by GF2 treatment, subsequently ameliorating inflammation in skin.	Tetradecanoylphorbol Acetate	78-81	interleukin 17A	Mus musculus	148-153
27596969-8	2016	Concomitantly, TPA-mediated skin inflammation was significantly ameliorated in IL-17A knock out mice.	Tetradecanoylphorbol Acetate	15-18	interleukin 17A	Mus musculus	79-85
27596969-10	2016	These results clearly suggest that GF2 treatment ameliorates TPA-induced dermal inflammation by inhibiting production of IL-17 and ROS in gammadelta T cells and neutrophils, respectively.	Tetradecanoylphorbol Acetate	61-64	interleukin 17A	Mus musculus	121-126
7867591-3	1995	We report that the effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and forskolin on a neuroblastoma cell line (LA-N-5) and a pheochromocytoma cell line (PC12) are mediated through both increased transcription of the NPY gene and through stabilization of NPY messenger RNA (mRNA).	Tetradecanoylphorbol Acetate	30-67	neuropeptide Y	Homo sapiens	223-226
7867591-3	1995	We report that the effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and forskolin on a neuroblastoma cell line (LA-N-5) and a pheochromocytoma cell line (PC12) are mediated through both increased transcription of the NPY gene and through stabilization of NPY messenger RNA (mRNA).	Tetradecanoylphorbol Acetate	30-67	neuropeptide Y	Homo sapiens	261-264
7867591-3	1995	We report that the effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and forskolin on a neuroblastoma cell line (LA-N-5) and a pheochromocytoma cell line (PC12) are mediated through both increased transcription of the NPY gene and through stabilization of NPY messenger RNA (mRNA).	Tetradecanoylphorbol Acetate	69-72	neuropeptide Y	Homo sapiens	223-226
27505250-7	2016	Next, we examined effects of 10 different agents on the expression of CD44 transcripts in cultured human keratinocytes, and found that several agents, particularly epidermal growth factor, hydrogen peroxide, phorbol 12-myristate 13-acetate, retinoic acid, calcium and fetal calf serum differently regulated their expressions in various patterns.	Tetradecanoylphorbol Acetate	208-239	CD44 molecule (Indian blood group)	Homo sapiens	70-74
7867591-3	1995	We report that the effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and forskolin on a neuroblastoma cell line (LA-N-5) and a pheochromocytoma cell line (PC12) are mediated through both increased transcription of the NPY gene and through stabilization of NPY messenger RNA (mRNA).	Tetradecanoylphorbol Acetate	69-72	neuropeptide Y	Homo sapiens	261-264
27012760-9	2016	These results demonstrate the potential of 1-3 as an anti-EPCR shedding reagent against PMA-mediated and CLP-mediated EPCR shedding.	Tetradecanoylphorbol Acetate	88-91	protein C receptor, endothelial	Mus musculus	58-62
7862129-7	1995	In addition, 12-O-tetradecanoylphorbol-13-acetate exposure of HepG2 cells results in a reciprocal decrease in HNF-3 alpha and -3 gamma expression which may facilitate interaction of AP-1 with the TTR AP-1-HNF-3 site.	Tetradecanoylphorbol Acetate	13-49	forkhead box A1	Homo sapiens	110-128
26929603-7	2016	RESULTS: ANDRO ameliorated the increase in the intracellular calcium, protein, and messenger RNA levels of TSLP induced by phorbol myristate acetate/calcium ionophore A23187, through the blocking of the receptor-interacting protein 2/caspase-1/NF-kappaB pathway in human mast cell line 1 cells.	Tetradecanoylphorbol Acetate	123-148	receptor interacting serine/threonine kinase 2	Homo sapiens	203-233
27130278-4	2016	Non-toxic hit compounds that blocked hypertrophy in response to phenylephrine (PE) and phorbol myristate acetate (PMA) were identified based on their ability to reduce cell size and inhibit expression of atrial natriuretic factor (ANF), which is a biomarker of pathological cardiac hypertrophy.	Tetradecanoylphorbol Acetate	87-112	natriuretic peptide A	Rattus norvegicus	204-229
27130278-4	2016	Non-toxic hit compounds that blocked hypertrophy in response to phenylephrine (PE) and phorbol myristate acetate (PMA) were identified based on their ability to reduce cell size and inhibit expression of atrial natriuretic factor (ANF), which is a biomarker of pathological cardiac hypertrophy.	Tetradecanoylphorbol Acetate	87-112	natriuretic peptide A	Rattus norvegicus	231-234
7878013-7	1995	Interestingly, the degree of apoptosis of CD4+ T cells by crosslinking of CD4 molecules via a combination of gp120, anti-gp120, and goat anti-mouse IgG was significantly greater for T cells primed with PMA-treated Mo than for unprimed T cells.	Tetradecanoylphorbol Acetate	202-205	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	109-114
27130278-4	2016	Non-toxic hit compounds that blocked hypertrophy in response to phenylephrine (PE) and phorbol myristate acetate (PMA) were identified based on their ability to reduce cell size and inhibit expression of atrial natriuretic factor (ANF), which is a biomarker of pathological cardiac hypertrophy.	Tetradecanoylphorbol Acetate	114-117	natriuretic peptide A	Rattus norvegicus	204-229
27130278-4	2016	Non-toxic hit compounds that blocked hypertrophy in response to phenylephrine (PE) and phorbol myristate acetate (PMA) were identified based on their ability to reduce cell size and inhibit expression of atrial natriuretic factor (ANF), which is a biomarker of pathological cardiac hypertrophy.	Tetradecanoylphorbol Acetate	114-117	natriuretic peptide A	Rattus norvegicus	231-234
26831087-4	2016	Tle1(Delta/Delta) macrophages produce increased inflammatory cytokines in response to Toll-like receptor (TLR) agonists and lipopolysaccharides (LPS), and Tle1(Delta/Delta) mice display an enhanced inflammatory response to ear skin 12-O-tetradecanoylphorbol-13-acetate treatment.	Tetradecanoylphorbol Acetate	232-268	transducin-like enhancer of split 1	Mus musculus	0-4
27349720-3	2016	This study aimed to assess the effects of phorbol myristate acetate/ionomycin (PMA/IONO) on the growth and apoptosis of the DLBCL cell line OCI-LY1, and their associations with A20, MALT1 and survivin levels.	Tetradecanoylphorbol Acetate	79-82	immunoglobulin kappa variable 1-27	Homo sapiens	177-180
26831087-4	2016	Tle1(Delta/Delta) macrophages produce increased inflammatory cytokines in response to Toll-like receptor (TLR) agonists and lipopolysaccharides (LPS), and Tle1(Delta/Delta) mice display an enhanced inflammatory response to ear skin 12-O-tetradecanoylphorbol-13-acetate treatment.	Tetradecanoylphorbol Acetate	232-268	transducin-like enhancer of split 1	Mus musculus	155-159
7878013-7	1995	Interestingly, the degree of apoptosis of CD4+ T cells by crosslinking of CD4 molecules via a combination of gp120, anti-gp120, and goat anti-mouse IgG was significantly greater for T cells primed with PMA-treated Mo than for unprimed T cells.	Tetradecanoylphorbol Acetate	202-205	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	121-126
21153151-10	1995	Treatment of PCOS theca cells with EGF, FGF, TGFbeta and TPA resulted in the inhibition of forskolin-stimulated 17alpha-hydroxyprogesterone production.	Tetradecanoylphorbol Acetate	57-60	epidermal growth factor	Homo sapiens	35-38
26848699-3	2016	Slug and the related transcription factor Snail were expressed at high levels in skin tumors induced by 7,12-dimethylbenz[alpha]anthracene application followed by 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	163-199	snail family zinc finger 1	Mus musculus	42-47
26848699-3	2016	Slug and the related transcription factor Snail were expressed at high levels in skin tumors induced by 7,12-dimethylbenz[alpha]anthracene application followed by 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment.	Tetradecanoylphorbol Acetate	201-204	snail family zinc finger 1	Mus musculus	42-47
26848699-4	2016	TPA-induced transient elevation of Slug and Snail proteins in normal mouse epidermis and studies in Slug transgenic mice indicated that Slug modulates TPA-induced epidermal hyperplasia and cutaneous inflammation.	Tetradecanoylphorbol Acetate	0-3	snail family zinc finger 1	Mus musculus	44-49
26848699-4	2016	TPA-induced transient elevation of Slug and Snail proteins in normal mouse epidermis and studies in Slug transgenic mice indicated that Slug modulates TPA-induced epidermal hyperplasia and cutaneous inflammation.	Tetradecanoylphorbol Acetate	151-154	snail family zinc finger 1	Mus musculus	44-49
26848699-5	2016	Although Snail family factors have been linked to inflammation via interactions with the cyclooxygenase-2 (COX-2) pathway, a pathway that also plays an important role in skin carcinogenesis, transient TPA induction of Slug and Snail appeared unrelated to COX-2 expression.	Tetradecanoylphorbol Acetate	201-204	snail family zinc finger 1	Mus musculus	9-14
27341144-7	2016	TIM-3 expression was induced in the cells using phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	48-73	hepatitis A virus cellular receptor 2	Homo sapiens	0-5
27341144-7	2016	TIM-3 expression was induced in the cells using phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	75-78	hepatitis A virus cellular receptor 2	Homo sapiens	0-5
27075590-7	2016	17-AAG inhibited PMA-induced cyclooxygenase-2 (COX-2) mRNA expression and protein level.	Tetradecanoylphorbol Acetate	17-20	N-methylpurine DNA glycosylase	Homo sapiens	3-6
21153153-5	1995	In this study, the effects of phorbol 12-myristate 13-acetate (PMA, a PKC activator) and staurosporine (ST, a PKC inhibitor) on IGF-I action were studied using immature rat ovarian granulosa cells.	Tetradecanoylphorbol Acetate	30-61	insulin-like growth factor 1	Rattus norvegicus	128-133
27035791-12	2016	Our findings revealed that the anti-invasive effects of Rev-AuNPs in response to TPA-stimulation were mediated by the suppression of MMP-9, COX-2, NF-kappaB, AP-1, PI3K/Akt and ERK and/or the activation of HO-1 signaling cascades.	Tetradecanoylphorbol Acetate	81-84	matrix metallopeptidase 9	Homo sapiens	133-138
21153153-5	1995	In this study, the effects of phorbol 12-myristate 13-acetate (PMA, a PKC activator) and staurosporine (ST, a PKC inhibitor) on IGF-I action were studied using immature rat ovarian granulosa cells.	Tetradecanoylphorbol Acetate	63-66	insulin-like growth factor 1	Rattus norvegicus	128-133
21153155-5	1995	Thrombin and the phorbol ester, TPA, compounds which regulate TF expression in other cell types by activation of protein kinase C (PKC), increased TF mRNA in both uterine organ cultures and in separated uterine cells.	Tetradecanoylphorbol Acetate	32-35	coagulation factor III, tissue factor	Homo sapiens	62-64
21153155-5	1995	Thrombin and the phorbol ester, TPA, compounds which regulate TF expression in other cell types by activation of protein kinase C (PKC), increased TF mRNA in both uterine organ cultures and in separated uterine cells.	Tetradecanoylphorbol Acetate	32-35	coagulation factor III, tissue factor	Homo sapiens	147-149
26721188-6	2016	SNARE complex formation in intact PC12 cells was similarly inhibited by forskolin (activator of PKA) and promoted by phorbol 12-myristate 13-acetate (PMA, activator of PKC).	Tetradecanoylphorbol Acetate	117-148	protein kinase C, gamma	Rattus norvegicus	168-171
26742640-7	2016	We observed that differentiation of SH-SY5Y human neuroblastoma cells induced by retinoic acid (RA), the phorbol ester PMA, or the gamma-secretase inhibitor DAPT resulted in an electrophoretic mobility shift of Fe65.	Tetradecanoylphorbol Acetate	119-122	amyloid beta precursor protein binding family B member 1	Homo sapiens	211-215
7544678-1	1995	The isoform of protein kinase C responsible for the inhibition of histamine-stimulated adenylate cyclase by the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), has been investigated in a particulate fraction prepared from the human gastric cancer cell line HGT-1.	Tetradecanoylphorbol Acetate	165-168	solute carrier family 25 member 16	Homo sapiens	268-273
26721188-6	2016	SNARE complex formation in intact PC12 cells was similarly inhibited by forskolin (activator of PKA) and promoted by phorbol 12-myristate 13-acetate (PMA, activator of PKC).	Tetradecanoylphorbol Acetate	150-153	protein kinase C, gamma	Rattus norvegicus	168-171
26721188-9	2016	Forced expression of WT SNAP-25 restored the secretory response of the SNAP-25-depleted cells to high-K(+), and this response was enhanced by forskolin or PMA.	Tetradecanoylphorbol Acetate	155-158	synaptosome associated protein 25	Rattus norvegicus	24-31
26721188-9	2016	Forced expression of WT SNAP-25 restored the secretory response of the SNAP-25-depleted cells to high-K(+), and this response was enhanced by forskolin or PMA.	Tetradecanoylphorbol Acetate	155-158	synaptosome associated protein 25	Rattus norvegicus	71-78
26614570-8	2016	Atorvastatin attenuated PMA-induced MMP-9 gelatinolytic activity by mechanisms not involving NO, although it increased nitrite concentrations, whereas sildenafil had no effects.	Tetradecanoylphorbol Acetate	24-27	matrix metallopeptidase 9	Homo sapiens	36-41
7544522-9	1995	After stimulation with lipopolysaccharide or phorbol myristate acetate, the MNCs expressed high levels of G-CSF and GM-CSF mRNA.	Tetradecanoylphorbol Acetate	45-70	colony stimulating factor 3	Homo sapiens	106-111
27257341-4	2016	Of the four polyphenols tested, CAPE significantly suppressed the 12-O-tetradecanoylphorbol 13-acetate (TPA)-elicited expression of cluster for differentiation (CD) 11b, 14, and 36, and this was accompanied by the inhibition of THP-1 cell adhesion to HUVEC.	Tetradecanoylphorbol Acetate	66-102	integrin subunit alpha M	Homo sapiens	132-168
27257341-4	2016	Of the four polyphenols tested, CAPE significantly suppressed the 12-O-tetradecanoylphorbol 13-acetate (TPA)-elicited expression of cluster for differentiation (CD) 11b, 14, and 36, and this was accompanied by the inhibition of THP-1 cell adhesion to HUVEC.	Tetradecanoylphorbol Acetate	104-107	integrin subunit alpha M	Homo sapiens	132-168
7544522-9	1995	After stimulation with lipopolysaccharide or phorbol myristate acetate, the MNCs expressed high levels of G-CSF and GM-CSF mRNA.	Tetradecanoylphorbol Acetate	45-70	colony stimulating factor 2	Homo sapiens	116-122
27257341-5	2016	CAPE also suppressed the activation of TPA-elicited nuclear factor-kappaB (NF-kappaB) and accumulation of NADPH oxidase 2 (NOX2)-derived reactive oxygen species (ROS), but did not affect extracellular signal-regulated kinase (ERK) phosphorylation.	Tetradecanoylphorbol Acetate	39-42	cytochrome b-245 beta chain	Homo sapiens	106-121
27257341-5	2016	CAPE also suppressed the activation of TPA-elicited nuclear factor-kappaB (NF-kappaB) and accumulation of NADPH oxidase 2 (NOX2)-derived reactive oxygen species (ROS), but did not affect extracellular signal-regulated kinase (ERK) phosphorylation.	Tetradecanoylphorbol Acetate	39-42	cytochrome b-245 beta chain	Homo sapiens	123-127
26376757-11	2016	In vitro treatment of splenocytes isolated from healthy mice with rmMFG-E8 showed significant downregulation in PMA/ionomycin-induced IL-17 expression.	Tetradecanoylphorbol Acetate	112-115	interleukin 17A	Mus musculus	134-139
8673471-1	1995	Stimulated human peripheral blood mononuclear cells (MNC) have been shown to express both G-CSF and GM-CSF, Furthermore, G-CSF is expressed by monocytes but not lymphocytes, whereas GM-CSF is expressed largely by T lymphocytes and at low levels in monocytes/macrophages, Here we present the effect of TPA (120-O-tetradecanoyl phorbol-13-acetate) on G-CSF and GM-CSF expression in stimulated human MNCs and T lymphocytes.	Tetradecanoylphorbol Acetate	301-304	colony stimulating factor 2	Homo sapiens	100-106
27476935-3	2016	p-Cymene was found to dose-dependently inhibit the 12-O-tetradecanoylphorbol 13-acetate (TPA)-augmented production and gene expression of MMP-9 in HT-1080 cells.	Tetradecanoylphorbol Acetate	51-87	matrix metallopeptidase 9	Homo sapiens	138-143
27476935-3	2016	p-Cymene was found to dose-dependently inhibit the 12-O-tetradecanoylphorbol 13-acetate (TPA)-augmented production and gene expression of MMP-9 in HT-1080 cells.	Tetradecanoylphorbol Acetate	89-92	matrix metallopeptidase 9	Homo sapiens	138-143
25753147-5	2016	Notably, a short-term DMBA/TPA challenge, modeling the initial stages of chemical skin carcinogenesis treatment, elicited an enhanced inflammation in p38delta-null skin compared with skin of wild-type mice, as assessed by measuring the expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-17, and TNFalpha.	Tetradecanoylphorbol Acetate	27-30	interleukin 17A	Mus musculus	304-309
27074999-3	2016	According to the enzyme activity and XPS measurements, when the GOx concentration is 4 mg mL(-1), they are most effectively immobilized (via the physical entrapment effect) and TPA-crosslinked GOx/PEI/CNT(TPA/[GOx/PEI/CNT]) forms pi conjugated bonds via chemical bonding, inducing the promotion of electron transfer by delocalization of electrons.	Tetradecanoylphorbol Acetate	177-180	hydroxyacid oxidase 1	Homo sapiens	193-196
27074999-3	2016	According to the enzyme activity and XPS measurements, when the GOx concentration is 4 mg mL(-1), they are most effectively immobilized (via the physical entrapment effect) and TPA-crosslinked GOx/PEI/CNT(TPA/[GOx/PEI/CNT]) forms pi conjugated bonds via chemical bonding, inducing the promotion of electron transfer by delocalization of electrons.	Tetradecanoylphorbol Acetate	205-208	hydroxyacid oxidase 1	Homo sapiens	64-67
8673471-1	1995	Stimulated human peripheral blood mononuclear cells (MNC) have been shown to express both G-CSF and GM-CSF, Furthermore, G-CSF is expressed by monocytes but not lymphocytes, whereas GM-CSF is expressed largely by T lymphocytes and at low levels in monocytes/macrophages, Here we present the effect of TPA (120-O-tetradecanoyl phorbol-13-acetate) on G-CSF and GM-CSF expression in stimulated human MNCs and T lymphocytes.	Tetradecanoylphorbol Acetate	301-304	colony stimulating factor 3	Homo sapiens	121-126
27074999-3	2016	According to the enzyme activity and XPS measurements, when the GOx concentration is 4 mg mL(-1), they are most effectively immobilized (via the physical entrapment effect) and TPA-crosslinked GOx/PEI/CNT(TPA/[GOx/PEI/CNT]) forms pi conjugated bonds via chemical bonding, inducing the promotion of electron transfer by delocalization of electrons.	Tetradecanoylphorbol Acetate	205-208	hydroxyacid oxidase 1	Homo sapiens	193-196
27074999-3	2016	According to the enzyme activity and XPS measurements, when the GOx concentration is 4 mg mL(-1), they are most effectively immobilized (via the physical entrapment effect) and TPA-crosslinked GOx/PEI/CNT(TPA/[GOx/PEI/CNT]) forms pi conjugated bonds via chemical bonding, inducing the promotion of electron transfer by delocalization of electrons.	Tetradecanoylphorbol Acetate	205-208	hydroxyacid oxidase 1	Homo sapiens	193-196
8673471-1	1995	Stimulated human peripheral blood mononuclear cells (MNC) have been shown to express both G-CSF and GM-CSF, Furthermore, G-CSF is expressed by monocytes but not lymphocytes, whereas GM-CSF is expressed largely by T lymphocytes and at low levels in monocytes/macrophages, Here we present the effect of TPA (120-O-tetradecanoyl phorbol-13-acetate) on G-CSF and GM-CSF expression in stimulated human MNCs and T lymphocytes.	Tetradecanoylphorbol Acetate	301-304	colony stimulating factor 2	Homo sapiens	182-188
27074999-4	2016	Due to the optimized GOx concentration and pi conjugated bonds, TPA/[GOx/PEI/CNT], including 4 mg mL(-1) GOx displays a high electron transfer rate, followed by excellent catalytic activity and EBC performance.	Tetradecanoylphorbol Acetate	64-67	hydroxyacid oxidase 1	Homo sapiens	21-24
27074999-4	2016	Due to the optimized GOx concentration and pi conjugated bonds, TPA/[GOx/PEI/CNT], including 4 mg mL(-1) GOx displays a high electron transfer rate, followed by excellent catalytic activity and EBC performance.	Tetradecanoylphorbol Acetate	64-67	hydroxyacid oxidase 1	Homo sapiens	69-72
8673471-1	1995	Stimulated human peripheral blood mononuclear cells (MNC) have been shown to express both G-CSF and GM-CSF, Furthermore, G-CSF is expressed by monocytes but not lymphocytes, whereas GM-CSF is expressed largely by T lymphocytes and at low levels in monocytes/macrophages, Here we present the effect of TPA (120-O-tetradecanoyl phorbol-13-acetate) on G-CSF and GM-CSF expression in stimulated human MNCs and T lymphocytes.	Tetradecanoylphorbol Acetate	301-304	colony stimulating factor 3	Homo sapiens	121-126
27074999-4	2016	Due to the optimized GOx concentration and pi conjugated bonds, TPA/[GOx/PEI/CNT], including 4 mg mL(-1) GOx displays a high electron transfer rate, followed by excellent catalytic activity and EBC performance.	Tetradecanoylphorbol Acetate	64-67	hydroxyacid oxidase 1	Homo sapiens	69-72
29199794-6	2016	RESULTS: The annual number of tissue plasminogen activator treatment (tPA) increased and door-to needle time significantly decreased from 2012 to 2014.	Tetradecanoylphorbol Acetate	70-73	chromosome 20 open reading frame 181	Homo sapiens	30-58
8673471-1	1995	Stimulated human peripheral blood mononuclear cells (MNC) have been shown to express both G-CSF and GM-CSF, Furthermore, G-CSF is expressed by monocytes but not lymphocytes, whereas GM-CSF is expressed largely by T lymphocytes and at low levels in monocytes/macrophages, Here we present the effect of TPA (120-O-tetradecanoyl phorbol-13-acetate) on G-CSF and GM-CSF expression in stimulated human MNCs and T lymphocytes.	Tetradecanoylphorbol Acetate	301-304	colony stimulating factor 2	Homo sapiens	182-188
8673471-2	1995	We observed that TPA (30nM) decreased G-CSF mRNA levels in MNCs, while ionomycin increased G-CSF in a dose-dependent manner.	Tetradecanoylphorbol Acetate	17-20	colony stimulating factor 3	Homo sapiens	38-43
8673471-3	1995	TPA and ionomycin individually increased GM-CSF mRNA levels in T-lymphocytes and MNCs.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 2	Homo sapiens	41-47
8673471-4	1995	Further, GM-CSF was induced synergistically by TPA plus ionomycin, whereas this combination markedly decreased G-CSF mRNA levels in MNCs.	Tetradecanoylphorbol Acetate	47-50	colony stimulating factor 2	Homo sapiens	9-15
26717978-5	2016	(PJT) on MMP-9 expression and the invasion of MCF-7 breast cancer cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	83-119	matrix metallopeptidase 9	Homo sapiens	9-14
26980735-3	2016	This study showed that melatonin attenuated the 12-O-tetradecanoylphorbol-13-acetate-induced migration of oral cancer cell lines, HSC-3 and OECM-1.	Tetradecanoylphorbol Acetate	48-84	DnaJ heat shock protein family (Hsp40) member B7	Homo sapiens	130-135
7843222-3	1995	In addition, the effects of PMA-mediated down-regulation on the expression of PKC epsilon and zeta were determined using high concentrations of PMA over 24- and 48-h time periods in these cells.	Tetradecanoylphorbol Acetate	28-31	protein kinase C epsilon	Homo sapiens	78-98
26717978-5	2016	(PJT) on MMP-9 expression and the invasion of MCF-7 breast cancer cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	121-124	matrix metallopeptidase 9	Homo sapiens	9-14
26717978-8	2016	The results indicated that the PJT-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involved the suppression of the PKCalpha/NF-kappaB pathway in MCF-7 cells.	Tetradecanoylphorbol Acetate	58-61	matrix metallopeptidase 9	Homo sapiens	70-75
27042241-14	2016	As a proof of principle, there was concordance in the kinetics of the RASSF1A and the serological cancer biomarkers CA 15-3, CEA, and TPA.	Tetradecanoylphorbol Acetate	134-137	Ras association domain family member 1	Homo sapiens	70-77
7843222-3	1995	In addition, the effects of PMA-mediated down-regulation on the expression of PKC epsilon and zeta were determined using high concentrations of PMA over 24- and 48-h time periods in these cells.	Tetradecanoylphorbol Acetate	144-147	protein kinase C epsilon	Homo sapiens	78-98
27127545-3	2016	In the present study, we demonstrated that the treatment of human breast cancer MCF-7 cells with phorbol ester (TPA), a protein kinase C activator, significantly induced cell proliferation and migration, and these were accompanied by the significant induction of Slug expression.	Tetradecanoylphorbol Acetate	112-115	snail family transcriptional repressor 2	Homo sapiens	263-267
7843222-6	1995	Expression of PKC epsilon was not completely depressed, however, even at the highest concentration of the phorbol ester after 48-h incubation with PMA.	Tetradecanoylphorbol Acetate	147-150	protein kinase C epsilon	Homo sapiens	14-25
27127545-4	2016	Moreover, the TPA-elicited induction of Slug expression was regulated by histone H3 acetylation and NADPH oxidase (NOX) 2-derived ROS signaling, indicating that ROS and histone acetylation are involved in TPA-elicited EMT processes.	Tetradecanoylphorbol Acetate	14-17	snail family transcriptional repressor 2	Homo sapiens	40-44
27127545-4	2016	Moreover, the TPA-elicited induction of Slug expression was regulated by histone H3 acetylation and NADPH oxidase (NOX) 2-derived ROS signaling, indicating that ROS and histone acetylation are involved in TPA-elicited EMT processes.	Tetradecanoylphorbol Acetate	205-208	snail family transcriptional repressor 2	Homo sapiens	40-44
26856460-2	2016	Evidence against the use of intravenous tissue plasminogen activator (IV tPA) has been suggested due to possibility of hemorrhage.	Tetradecanoylphorbol Acetate	73-76	chromosome 20 open reading frame 181	Homo sapiens	40-68
8821624-6	1995	Expression of this antisense DNA in the presence of zinc in PMA-induced serum-starved cells completely inhibited induced appearance of p67 mRNA and subsequent protein synthesis.	Tetradecanoylphorbol Acetate	60-63	methionyl aminopeptidase 2	Rattus norvegicus	135-138
7768965-1	1995	As a part of a series of investigations on the functions of TIS21 and TIS1 genes, we measured in vivo 12-O-tetradecanoylphorbol-13-acetate (TPA) inducibility of primary response genes (TIS21, TIS8 and TIS1) in the Balb/c mice and the changes of TIS gene expression in thymic carcinoma tissues and A549 and NCIH69 human lung cancer cell lines.	Tetradecanoylphorbol Acetate	102-138	nuclear receptor subfamily 4, group A, member 1	Mus musculus	70-74
26840563-11	2016	On the other hand, HGF and TPA increased cysteinyl glutathione-containing HSP60, consistent with the decrease of cysteine (-SH)-containing HSP60.	Tetradecanoylphorbol Acetate	27-30	heat shock protein family D (Hsp60) member 1	Homo sapiens	74-79
26840563-11	2016	On the other hand, HGF and TPA increased cysteinyl glutathione-containing HSP60, consistent with the decrease of cysteine (-SH)-containing HSP60.	Tetradecanoylphorbol Acetate	27-30	heat shock protein family D (Hsp60) member 1	Homo sapiens	139-144
26459162-6	2016	Interestingly, data obtained using calcium imaging techniques suggested that NED-180 reduced the TPA-induced activation of TRPM1 (melastatin), which could explain the NED-180-induced inhibition of melanogenesis.	Tetradecanoylphorbol Acetate	97-100	transient receptor potential cation channel, subfamily M, member 1	Mus musculus	123-128
7768965-1	1995	As a part of a series of investigations on the functions of TIS21 and TIS1 genes, we measured in vivo 12-O-tetradecanoylphorbol-13-acetate (TPA) inducibility of primary response genes (TIS21, TIS8 and TIS1) in the Balb/c mice and the changes of TIS gene expression in thymic carcinoma tissues and A549 and NCIH69 human lung cancer cell lines.	Tetradecanoylphorbol Acetate	102-138	early growth response 1	Mus musculus	192-196
7768965-1	1995	As a part of a series of investigations on the functions of TIS21 and TIS1 genes, we measured in vivo 12-O-tetradecanoylphorbol-13-acetate (TPA) inducibility of primary response genes (TIS21, TIS8 and TIS1) in the Balb/c mice and the changes of TIS gene expression in thymic carcinoma tissues and A549 and NCIH69 human lung cancer cell lines.	Tetradecanoylphorbol Acetate	102-138	nuclear receptor subfamily 4, group A, member 1	Mus musculus	201-205
7768965-1	1995	As a part of a series of investigations on the functions of TIS21 and TIS1 genes, we measured in vivo 12-O-tetradecanoylphorbol-13-acetate (TPA) inducibility of primary response genes (TIS21, TIS8 and TIS1) in the Balb/c mice and the changes of TIS gene expression in thymic carcinoma tissues and A549 and NCIH69 human lung cancer cell lines.	Tetradecanoylphorbol Acetate	140-143	nuclear receptor subfamily 4, group A, member 1	Mus musculus	70-74
26836805-13	2016	The frequencies of B10 cells were similar in the three groups, irrespective of whether IL-10 was induced by a combination of phorbol 12-myristate 13-acetate (PMA) and ionomycin, by CpG oligodeoxynucletodies (ODN) 2006, or by TG.	Tetradecanoylphorbol Acetate	158-161	interleukin 10	Homo sapiens	87-92
26651527-7	2015	4DN significantly decreased the expression levels of iNOS, COX-2, and MMP-9, suppressed phosphorylation of PI3K/Akt and ERK, and increased the levels of HO-1 and NQO1 in TPA-treated mice.	Tetradecanoylphorbol Acetate	170-173	NAD(P)H dehydrogenase, quinone 1	Mus musculus	162-166
7768965-2	1995	In vivo induction of the TIS genes (TIS21, -8 and -1) by intraperitoneal injection of TPA was dramatic only at the needle contact site, i.e. in the abdominal muscle, not in the thigh muscle.	Tetradecanoylphorbol Acetate	86-89	BTG anti-proliferation factor 2	Homo sapiens	36-52
7768965-6	1995	Interestingly, induction of TIS21 expression was obliterated in the human lung cancer cells; A549 cells completely lost the ability to express TIS21 after a combined treatment of TPA and cycloheximide.	Tetradecanoylphorbol Acetate	179-182	BTG anti-proliferation factor 2	Homo sapiens	28-33
26718128-4	2016	Hispolon decreased the level of cellular ROS significantly and repressed TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK), accompanied by upregulation of E-cadherin and downregulation of the transcriptional repressor Slug.	Tetradecanoylphorbol Acetate	73-76	snail family transcriptional repressor 2	Homo sapiens	243-247
7768965-6	1995	Interestingly, induction of TIS21 expression was obliterated in the human lung cancer cells; A549 cells completely lost the ability to express TIS21 after a combined treatment of TPA and cycloheximide.	Tetradecanoylphorbol Acetate	179-182	BTG anti-proliferation factor 2	Homo sapiens	143-148
26981393-3	2016	We used the mouse EL4 T cell as a model system to study genes that are induced as a result of T cell activation using phorbol myristate acetate (PMA) and calcium ionomycin (I) as stimuli.	Tetradecanoylphorbol Acetate	118-143	epilepsy 4	Mus musculus	18-21
8705253-7	1995	PMA treatment also caused an increase in myeloperoxidase (MPO) activity in the lung, suggestive of neutrophil infiltration.	Tetradecanoylphorbol Acetate	0-3	myeloperoxidase	Rattus norvegicus	41-56
26981393-3	2016	We used the mouse EL4 T cell as a model system to study genes that are induced as a result of T cell activation using phorbol myristate acetate (PMA) and calcium ionomycin (I) as stimuli.	Tetradecanoylphorbol Acetate	145-148	epilepsy 4	Mus musculus	18-21
26133738-9	2015	In the parallel experiments, we demonstrated that TG2 inhibition reduced RANKL expression in both HPDL cells from CP patients and monocytes differentiated to macrophages by tetradecanoyl phorbol acetate treatment.	Tetradecanoylphorbol Acetate	173-202	TNF superfamily member 11	Homo sapiens	73-78
26505736-4	2016	KEY RESULTS: PGE2 inhibited PMA-induced NET formation in vitro through EP2 and EP4 Galphas-coupled receptors.	Tetradecanoylphorbol Acetate	28-31	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	71-74
8705253-7	1995	PMA treatment also caused an increase in myeloperoxidase (MPO) activity in the lung, suggestive of neutrophil infiltration.	Tetradecanoylphorbol Acetate	0-3	myeloperoxidase	Rattus norvegicus	58-61
7818763-4	1995	PGHS-1 steady-state levels remained unchanged upon induction of acute or chronic epidermal hyperplasia by TPA and in papillomas and carcinomas generated by the initiation-promotion procedure, with 7,12-dimethylbenz[a]anthracene as initiator and TPA as promoter.	Tetradecanoylphorbol Acetate	106-109	prostaglandin-endoperoxide synthase 1	Mus musculus	0-6
26498639-11	2015	The levels of MMP-2, MMP-9, E-cad and integrin beta1 in the TPA-induced A549 cells changed markedly, compared with the untreated cells.	Tetradecanoylphorbol Acetate	60-63	matrix metallopeptidase 9	Homo sapiens	21-26
26498639-11	2015	The levels of MMP-2, MMP-9, E-cad and integrin beta1 in the TPA-induced A549 cells changed markedly, compared with the untreated cells.	Tetradecanoylphorbol Acetate	60-63	integrin subunit beta 1	Homo sapiens	38-52
26430963-5	2015	Further investigation found that H3K36 dimethylation was significantly reduced near the COX-2 promoter because histone demethylase 2A (KDM2A) was recruited to the COX-2 promoter after TPA treatment.	Tetradecanoylphorbol Acetate	184-187	lysine demethylase 2A	Homo sapiens	135-140
26430963-6	2015	In addition, the transcription factor c-Fos was found to be required to recruit KDM2A to the COX-2 promoter for reactivation of COX-2 in response to TPA treatment in both the H719 and H460 cell lines.	Tetradecanoylphorbol Acetate	149-152	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-43
26430963-6	2015	In addition, the transcription factor c-Fos was found to be required to recruit KDM2A to the COX-2 promoter for reactivation of COX-2 in response to TPA treatment in both the H719 and H460 cell lines.	Tetradecanoylphorbol Acetate	149-152	lysine demethylase 2A	Homo sapiens	80-85
26372376-6	2015	Firstly, AgNPs inhibit phorbol 12-myristate 13-acetate (PMA)-induced monocyte differentiation by down-regulating both expression of surface marker CD11b and response to lipopolysaccharide (LPS) stimulation.	Tetradecanoylphorbol Acetate	56-59	integrin subunit alpha M	Homo sapiens	147-152
7818763-4	1995	PGHS-1 steady-state levels remained unchanged upon induction of acute or chronic epidermal hyperplasia by TPA and in papillomas and carcinomas generated by the initiation-promotion procedure, with 7,12-dimethylbenz[a]anthracene as initiator and TPA as promoter.	Tetradecanoylphorbol Acetate	245-248	prostaglandin-endoperoxide synthase 1	Mus musculus	0-6
7539127-8	1995	Activation of protein kinase C by beta-phorbol 12-myristate, 13-acetate resulted in a dose-dependent inhibition of the response to TRH, suggesting that protein kinase C was involved in desensitization.	Tetradecanoylphorbol Acetate	34-71	thyrotropin-releasing hormone L homeolog	Xenopus laevis	131-134
26431317-7	2015	Further analysis revealed that TPA+UVC co-exposure caused synergistic perturbation of specific genes associated with p53, AP-1 and inflammatory pathways important in carcinogenesis.	Tetradecanoylphorbol Acetate	31-34	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	122-126
26217011-7	2015	Tetradecanoyl phorbol acetate (TPA)-induced CD44 cleavage requires dephosphorylation of ICD serine 291, while induced neuregulin release depends on the phosphorylation of several NRG1-ICD serines, in part mediated by protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	0-29	CD44 molecule (Indian blood group)	Homo sapiens	44-48
26217011-7	2015	Tetradecanoyl phorbol acetate (TPA)-induced CD44 cleavage requires dephosphorylation of ICD serine 291, while induced neuregulin release depends on the phosphorylation of several NRG1-ICD serines, in part mediated by protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	31-34	CD44 molecule (Indian blood group)	Homo sapiens	44-48
7892286-7	1995	Further studies show that genistein significantly inhibits TPA-induced proto-oncogene expression (c-fos) in mouse skin in a dose-dependent manner.	Tetradecanoylphorbol Acetate	59-62	FBJ osteosarcoma oncogene	Mus musculus	98-103
26375594-8	2015	In vitro stimulation of peripheral blood lymphocytes with ovalbumin followed by stimulation with PMA/ionomycin allowed the identification by flow cytometry of CD4+ T cells producing either IL-17A, IFN-gamma, or both cytokines.	Tetradecanoylphorbol Acetate	97-100	interferon gamma	Bos taurus	197-206
7961634-8	1994	In contrast, inhibition of protein kinase C by calphostin C and chelerythrine or down-regulation with phorbol 12-myristate 13-acetate drastically reduces PGE2 and arachidonic acid-induced c-fos and Egr-1 mRNA levels.	Tetradecanoylphorbol Acetate	102-133	FBJ osteosarcoma oncogene	Mus musculus	188-193
26033110-4	2015	PKC activation by phorbol 12-myristate 13-acetate causes cortactin phosphorylation, filopodial retraction and F-actin-bundle loss.	Tetradecanoylphorbol Acetate	18-49	cortactin	Homo sapiens	57-66
7961634-8	1994	In contrast, inhibition of protein kinase C by calphostin C and chelerythrine or down-regulation with phorbol 12-myristate 13-acetate drastically reduces PGE2 and arachidonic acid-induced c-fos and Egr-1 mRNA levels.	Tetradecanoylphorbol Acetate	102-133	early growth response 1	Mus musculus	198-203
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	Tetradecanoylphorbol Acetate	56-59	mitogen-activated protein kinase 8	Mus musculus	165-169
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	Tetradecanoylphorbol Acetate	56-59	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	226-229
7819061-6	1994	Of the cell lines which did not express IL-3 under unstimulated condition, only HEL cells were able to express IL-3 mRNA after treatment with PMA for 72 h. Furthermore, the proliferation of DAMI and MEG-01 cells could be enhanced in the presence of IL-3 and suppressed by the anti-IL-3 antibody and the IL-3 antisense oligodexyonucleotides (ODNs).	Tetradecanoylphorbol Acetate	142-145	interleukin 3	Homo sapiens	111-115
7819061-6	1994	Of the cell lines which did not express IL-3 under unstimulated condition, only HEL cells were able to express IL-3 mRNA after treatment with PMA for 72 h. Furthermore, the proliferation of DAMI and MEG-01 cells could be enhanced in the presence of IL-3 and suppressed by the anti-IL-3 antibody and the IL-3 antisense oligodexyonucleotides (ODNs).	Tetradecanoylphorbol Acetate	142-145	interleukin 3	Homo sapiens	111-115
27057457-4	2016	In the current study, we therefore investigated how the most potent and frequently used tumor promoter 12-O-Tetradecanoylphorbol-13-acetate (TPA) affects the development and progression of carcinogen-induced melanomas in Hgf-Cdk4(R24C) mice.	Tetradecanoylphorbol Acetate	103-139	hepatocyte growth factor	Mus musculus	221-224
7819061-6	1994	Of the cell lines which did not express IL-3 under unstimulated condition, only HEL cells were able to express IL-3 mRNA after treatment with PMA for 72 h. Furthermore, the proliferation of DAMI and MEG-01 cells could be enhanced in the presence of IL-3 and suppressed by the anti-IL-3 antibody and the IL-3 antisense oligodexyonucleotides (ODNs).	Tetradecanoylphorbol Acetate	142-145	interleukin 3	Homo sapiens	111-115
27057457-4	2016	In the current study, we therefore investigated how the most potent and frequently used tumor promoter 12-O-Tetradecanoylphorbol-13-acetate (TPA) affects the development and progression of carcinogen-induced melanomas in Hgf-Cdk4(R24C) mice.	Tetradecanoylphorbol Acetate	141-144	hepatocyte growth factor	Mus musculus	221-224
27057457-6	2016	Using a highly metastatic Hgf-Cdk4(R24C) melanoma skin transplant we could show that TPA enhances systemic spread of melanoma cells which was depended on intact TLR4 signaling in recipient mice and on the presence of neutrophils.	Tetradecanoylphorbol Acetate	85-88	hepatocyte growth factor	Mus musculus	26-29
7819061-6	1994	Of the cell lines which did not express IL-3 under unstimulated condition, only HEL cells were able to express IL-3 mRNA after treatment with PMA for 72 h. Furthermore, the proliferation of DAMI and MEG-01 cells could be enhanced in the presence of IL-3 and suppressed by the anti-IL-3 antibody and the IL-3 antisense oligodexyonucleotides (ODNs).	Tetradecanoylphorbol Acetate	142-145	interleukin 3	Homo sapiens	111-115
7876334-13	1994	The Con A-induced PI-turnover was not affected by PMA (50 nM), but the NaVO3-induced PI-turnover was increased over 2-fold by PMA (50 nM), suggesting that the Con A-induced PLC in intact splenocytes is different from NaVO3-induced PLC.	Tetradecanoylphorbol Acetate	126-129	heparan sulfate proteoglycan 2	Homo sapiens	173-176
25486434-3	2015	Ppp6c deficiency induced papilloma formation with 7,12-dimethylbenz (a) anthracene (DMBA) only, and development of those papillomas was significantly accelerated compared with that seen following DMBA/TPA (12-O-tetradecanoylphorbol 13-acetate) treatment of wild-type mice.	Tetradecanoylphorbol Acetate	206-242	protein phosphatase 6, catalytic subunit	Mus musculus	0-5
7876334-13	1994	The Con A-induced PI-turnover was not affected by PMA (50 nM), but the NaVO3-induced PI-turnover was increased over 2-fold by PMA (50 nM), suggesting that the Con A-induced PLC in intact splenocytes is different from NaVO3-induced PLC.	Tetradecanoylphorbol Acetate	126-129	heparan sulfate proteoglycan 2	Homo sapiens	231-234
7720005-5	1994	The activity of tPA might be inhibited b PAI-1, although the content of tPA in the culture medium seemed to be increased after endothelial cell injury.	Tetradecanoylphorbol Acetate	16-19	serpin family E member 1	Homo sapiens	41-46
26176694-7	2015	The levels of cleaved caspase-3, cleaved PARP (the substrate of caspase-3) and caspase-9 (the modulator of the caspase-3), which had increased following IR injury, were significantly inhibited by NSP in both wild type and tPA-/- mice.	Tetradecanoylphorbol Acetate	222-225	caspase 3	Mus musculus	22-31
26176694-7	2015	The levels of cleaved caspase-3, cleaved PARP (the substrate of caspase-3) and caspase-9 (the modulator of the caspase-3), which had increased following IR injury, were significantly inhibited by NSP in both wild type and tPA-/- mice.	Tetradecanoylphorbol Acetate	222-225	poly (ADP-ribose) polymerase family, member 1	Mus musculus	41-45
26176694-7	2015	The levels of cleaved caspase-3, cleaved PARP (the substrate of caspase-3) and caspase-9 (the modulator of the caspase-3), which had increased following IR injury, were significantly inhibited by NSP in both wild type and tPA-/- mice.	Tetradecanoylphorbol Acetate	222-225	caspase 3	Mus musculus	64-73
26176694-7	2015	The levels of cleaved caspase-3, cleaved PARP (the substrate of caspase-3) and caspase-9 (the modulator of the caspase-3), which had increased following IR injury, were significantly inhibited by NSP in both wild type and tPA-/- mice.	Tetradecanoylphorbol Acetate	222-225	caspase 3	Mus musculus	64-73
7980409-6	1994	After stimulation with phorbol 12-myristate 13-acetate and phytohaemagglutinin for 10 min, p105-NF-kappa B and p50-NF-kappa B, but not p36-I kappa B, were highly phosphorylated.	Tetradecanoylphorbol Acetate	23-54	annexin A2	Homo sapiens	135-138
25626394-7	2015	We demonstrated that PGRN expression was dramatically enhanced in the psoriasis-like lesions of TPA-treated WT mice, in accordance with human psoriatic lesions.	Tetradecanoylphorbol Acetate	96-99	granulin	Mus musculus	21-25
25626394-8	2015	Surprisingly, PGRN(-/-) mice were more sensitive to the development of TPA-induced psoriasis-like inflammation.	Tetradecanoylphorbol Acetate	71-74	granulin	Mus musculus	14-18
7531462-8	1994	Anti-APO-1-induced apoptosis was also found to be inhibited in Jurkat cells by the induction of protein kinase C (PKC) with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	124-160	Fas cell surface death receptor	Homo sapiens	5-10
25626394-9	2015	The mechanism underlying this increased sensitivity of PGRN(-/-) mice to TPA-induced psoriasis-like inflammation was impaired differentiation of regulatory T cells in lymph nodes and decreased recruitment of these cells in the affected skin, which results in more severe inflammation.	Tetradecanoylphorbol Acetate	73-76	granulin	Mus musculus	55-59
7531462-8	1994	Anti-APO-1-induced apoptosis was also found to be inhibited in Jurkat cells by the induction of protein kinase C (PKC) with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	162-165	Fas cell surface death receptor	Homo sapiens	5-10
26021873-9	2015	The conditioned medium (CM) from HepG2 cells that overexpressed miR-26a reduced the migration ability of THP-1 cells stimulated by phorbol myristate acetate (PMA) increased expression of interleukin (IL)-12b or IL-23 mRNA and decreased expression of chemokine (C-C motif) ligand (CCL)22, CCL17, and IL-10 mRNA, in comparison to the medium from the parental HepG2 cells.	Tetradecanoylphorbol Acetate	131-156	interleukin 12B	Homo sapiens	187-207
7955078-9	1994	Topical application of 5 nmol TPA to the backs of CD-1 mice once a day for 5 days caused epidermal hyperplasia and the levels of c-Jun were increased in the suprabasal layer of the epidermis and in the muscle layer of the dermis.	Tetradecanoylphorbol Acetate	30-33	CD1 antigen complex	Mus musculus	50-54
7852866-2	1994	Stimulation of the leukemic T cell line Jurkat with the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore ionomycin rapidly and transiently increased LDL receptor mRNA levels.	Tetradecanoylphorbol Acetate	70-101	low density lipoprotein receptor	Homo sapiens	178-190
26016954-7	2015	To assess the maximal frequency of inducible IL-10+ B cells in the three donor groups PBMCs were stimulated with PMA/ionomycin.	Tetradecanoylphorbol Acetate	113-116	interleukin 10	Homo sapiens	45-50
25871385-6	2015	Furthermore, in response to DMBA/TPA, the Dsg2/Ptc1+/lacZ mice developed squamous lessons earlier than the WT, Ptc1(+/lacZ), and Inv-Dsg2 littermates.	Tetradecanoylphorbol Acetate	33-36	patched 1	Mus musculus	47-51
7852866-2	1994	Stimulation of the leukemic T cell line Jurkat with the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore ionomycin rapidly and transiently increased LDL receptor mRNA levels.	Tetradecanoylphorbol Acetate	103-106	low density lipoprotein receptor	Homo sapiens	178-190
25871385-6	2015	Furthermore, in response to DMBA/TPA, the Dsg2/Ptc1+/lacZ mice developed squamous lessons earlier than the WT, Ptc1(+/lacZ), and Inv-Dsg2 littermates.	Tetradecanoylphorbol Acetate	33-36	patched 1	Mus musculus	111-115
25871385-6	2015	Furthermore, in response to DMBA/TPA, the Dsg2/Ptc1+/lacZ mice developed squamous lessons earlier than the WT, Ptc1(+/lacZ), and Inv-Dsg2 littermates.	Tetradecanoylphorbol Acetate	33-36	inversin	Mus musculus	129-132
7916993-4	1994	A subset of TIS genes (TIS1, TIS10, and TIS21) was preferentially induced by TPA in P-cells.	Tetradecanoylphorbol Acetate	77-80	BTG anti-proliferation factor 2	Homo sapiens	40-45
25871385-7	2015	Additionally, DMBA/TPA induced BCC formation in all mice harboring the Ptc1(+/lacZ) gene and the presence of Dsg2 in Dsg2/Ptc1(+/lacZ) mice doubled the BCC tumor burden.	Tetradecanoylphorbol Acetate	19-22	patched 1	Mus musculus	71-75
25871385-7	2015	Additionally, DMBA/TPA induced BCC formation in all mice harboring the Ptc1(+/lacZ) gene and the presence of Dsg2 in Dsg2/Ptc1(+/lacZ) mice doubled the BCC tumor burden.	Tetradecanoylphorbol Acetate	19-22	patched 1	Mus musculus	122-126
7916993-6	1994	TIS1 and TIS21 protein levels were also greater in TPA-treated P-cells than P+ cells.	Tetradecanoylphorbol Acetate	51-54	BTG anti-proliferation factor 2	Homo sapiens	9-14
7916993-7	1994	Forskolin, a cAMP-elevating anti-promoter, increased TPA-induced levels of TIS1, TIS10, and TIS21 mRNAs in P+ cells, ruling in potential roles for these genes in modulating tumor promotion.	Tetradecanoylphorbol Acetate	53-56	BTG anti-proliferation factor 2	Homo sapiens	92-97
25875631-9	2015	Chrysin inhibited phorbol-12-myristate 13-acetate (PMA)-induced MMP-9 expression in a dose-dependent manner.	Tetradecanoylphorbol Acetate	18-49	matrix metallopeptidase 9	Homo sapiens	64-69
25875631-9	2015	Chrysin inhibited phorbol-12-myristate 13-acetate (PMA)-induced MMP-9 expression in a dose-dependent manner.	Tetradecanoylphorbol Acetate	51-54	matrix metallopeptidase 9	Homo sapiens	64-69
7929090-6	1994	The phosphotyrosine content of p125FAK, paxillin, and p130 was also increased following stimulation with phorbol 12-myristate 13-acetate (PMA) (0.1 microM).	Tetradecanoylphorbol Acetate	105-136	PTK2 protein tyrosine kinase 2	Mus musculus	31-38
7916295-3	1994	We observed that phorbol 12-myristate 13-acetate, Mn2+, cross-linking of CD3 or activating antibodies against LFA-1 enhanced LFA-1-mediated T cell adhesion to ICAM-2 and -3, although to a lesser extent than to ICAM-1.	Tetradecanoylphorbol Acetate	17-48	intercellular adhesion molecule 2	Homo sapiens	159-172
25530093-8	2015	Moreover, TPA (12-O-tetradecanoylphorbol-13-acetate), a potent inducer of c-Jun, could remarkably promote viral immediate-early gene wsv069 transcription in crayfish hemocytes.	Tetradecanoylphorbol Acetate	10-13	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-79
7829134-2	1994	In this study, the protective effect of ADF/TRX on the cytotoxicity of endothelial cells caused by phorbol myristate acetate (PMA)-activated neutrophils or hydrogen peroxide (H2O2) was examined.	Tetradecanoylphorbol Acetate	99-124	thioredoxin	Homo sapiens	40-43
25530093-8	2015	Moreover, TPA (12-O-tetradecanoylphorbol-13-acetate), a potent inducer of c-Jun, could remarkably promote viral immediate-early gene wsv069 transcription in crayfish hemocytes.	Tetradecanoylphorbol Acetate	15-51	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-79
7829134-2	1994	In this study, the protective effect of ADF/TRX on the cytotoxicity of endothelial cells caused by phorbol myristate acetate (PMA)-activated neutrophils or hydrogen peroxide (H2O2) was examined.	Tetradecanoylphorbol Acetate	99-124	thioredoxin	Homo sapiens	44-47
25682767-2	2015	It was suggested that the interleukin-23 (IL-23)/IL-17A cytokine axis played a critical role in the pathogenesis of 12-O-tetradecanoyl phorbol 12-myristate 13-acetate (TPA)-induced K14-VEGF transgenic psoriasis-like mice model.	Tetradecanoylphorbol Acetate	168-171	interleukin 17A	Mus musculus	49-55
25682767-2	2015	It was suggested that the interleukin-23 (IL-23)/IL-17A cytokine axis played a critical role in the pathogenesis of 12-O-tetradecanoyl phorbol 12-myristate 13-acetate (TPA)-induced K14-VEGF transgenic psoriasis-like mice model.	Tetradecanoylphorbol Acetate	168-171	vascular endothelial growth factor A	Mus musculus	185-189
25682767-3	2015	Here, we report that topical use of a curcumin gel formulation inhibited TPA-induced Th1 inflammation in K14-VEGF transgenic mice ears but not Th17 inflammation as expected.	Tetradecanoylphorbol Acetate	73-76	vascular endothelial growth factor A	Mus musculus	109-113
7829134-2	1994	In this study, the protective effect of ADF/TRX on the cytotoxicity of endothelial cells caused by phorbol myristate acetate (PMA)-activated neutrophils or hydrogen peroxide (H2O2) was examined.	Tetradecanoylphorbol Acetate	126-129	thioredoxin	Homo sapiens	40-43
25682767-7	2015	In conclusion, curcumin inhibits TPA-induced Th1 inflammation in K14-VEGF transgenic mice which has not been previously described.	Tetradecanoylphorbol Acetate	33-36	vascular endothelial growth factor A	Mus musculus	69-73
7829134-2	1994	In this study, the protective effect of ADF/TRX on the cytotoxicity of endothelial cells caused by phorbol myristate acetate (PMA)-activated neutrophils or hydrogen peroxide (H2O2) was examined.	Tetradecanoylphorbol Acetate	126-129	thioredoxin	Homo sapiens	44-47
7799308-8	1994	Northern analysis showed a 4.5-fold increase in the abundance of specific mRNA for latent matrix metalloproteinase-1 following treatment of cells with phorbol myristate acetate, but a marked decrease following interferon treatment.	Tetradecanoylphorbol Acetate	151-176	matrix metallopeptidase 1	Homo sapiens	90-116
7849624-4	1994	Following a 24h, 48h, and 72h treatment, with 16 nM TPA, c-myc mRNA was suppressed by 91%, 83%, and 78%, respectively, in good agreement with the extent of growth reduction observed.	Tetradecanoylphorbol Acetate	52-55	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	57-62
7849624-5	1994	At the low dose of TPA (0.16 nM), however, the c-myc mRNA expression remained inhibited by 85% even though cell growth was only reduced by 10-14%.	Tetradecanoylphorbol Acetate	19-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	47-52
7522191-2	1994	In this study we found that most of the vimentin of undifferentiated HL60 and cells induced to differentiate either along the monocytoid pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA) or along the granulocytic pathway by retinoic acid was soluble in a buffer containing 1% Triton X-100/0.6 mol/l KCl in which the intermediate filament proteins usually are not soluble.	Tetradecanoylphorbol Acetate	148-184	vimentin	Homo sapiens	40-48
26414495-7	2015	Production of reactive oxygen species (ROS) induced by PMA (126.7 +- 2.1%) was markedly attenuated by curcumin, DMC, and BDMC to 99.5 +- 7.8%, 87.8 +- 8.2%, and 89.8 +- 7.6%, respectively, resulting in the down-regulation of CD11b and MMP-9 expression.	Tetradecanoylphorbol Acetate	55-58	integrin subunit alpha M	Homo sapiens	225-230
26414495-7	2015	Production of reactive oxygen species (ROS) induced by PMA (126.7 +- 2.1%) was markedly attenuated by curcumin, DMC, and BDMC to 99.5 +- 7.8%, 87.8 +- 8.2%, and 89.8 +- 7.6%, respectively, resulting in the down-regulation of CD11b and MMP-9 expression.	Tetradecanoylphorbol Acetate	55-58	matrix metallopeptidase 9	Homo sapiens	235-240
7522191-2	1994	In this study we found that most of the vimentin of undifferentiated HL60 and cells induced to differentiate either along the monocytoid pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA) or along the granulocytic pathway by retinoic acid was soluble in a buffer containing 1% Triton X-100/0.6 mol/l KCl in which the intermediate filament proteins usually are not soluble.	Tetradecanoylphorbol Acetate	186-189	vimentin	Homo sapiens	40-48
7522191-5	1994	The distribution of both forms of vimentin changed during induction of differentiation by TPA and after 24 h the Mr 54,000 species was predominant.	Tetradecanoylphorbol Acetate	90-93	vimentin	Homo sapiens	34-42
7522191-6	1994	After an additional 24 h exposure to TPA the relative levels of the two forms of vimentin approached equivalence and a high level of vimentin degradation products was seen.	Tetradecanoylphorbol Acetate	37-40	vimentin	Homo sapiens	81-89
7522191-6	1994	After an additional 24 h exposure to TPA the relative levels of the two forms of vimentin approached equivalence and a high level of vimentin degradation products was seen.	Tetradecanoylphorbol Acetate	37-40	vimentin	Homo sapiens	133-141
25401496-0	2015	Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells.	Tetradecanoylphorbol Acetate	23-26	matrix metallopeptidase 9	Homo sapiens	35-61
7522191-7	1994	These results suggest that TPA may increase vimentin degradation along a pathway that has a Mr 54,000 intermediate.	Tetradecanoylphorbol Acetate	27-30	vimentin	Homo sapiens	44-52
25401496-8	2015	Zymography and Western blot analyses suggested that resveratrol inhibited TPA-induced MMP-9 gelatinolytic activity and protein expression.	Tetradecanoylphorbol Acetate	74-77	matrix metallopeptidase 9	Homo sapiens	86-91
8035792-8	1994	EGR1 and EGR2 increased IL-3 promoter activity when the transfected cells were stimulated with phorbol-12-myristate-13-acetate and A23187.	Tetradecanoylphorbol Acetate	95-126	early growth response 1	Homo sapiens	0-4
26117319-7	2015	In loss-of-function experiments, genetic silencing of the NADPH oxidase subunit Nox2 blocked PMA-induced intracellular TRX-1/PRX-1 downregulation in macrophages.	Tetradecanoylphorbol Acetate	93-96	cytochrome b-245 beta chain	Homo sapiens	80-84
8035792-8	1994	EGR1 and EGR2 increased IL-3 promoter activity when the transfected cells were stimulated with phorbol-12-myristate-13-acetate and A23187.	Tetradecanoylphorbol Acetate	95-126	early growth response 2	Homo sapiens	9-13
24464587-2	2015	Topical treatment with both 12-O-tetradecanoylphorbol-13-acetate (TPA) and 3-methyl-1,8-dihydroxy-9-anthrone (chrysarobin or CHRY) led to rapid phosphorylation of Stat1 on both tyrosine (Y701) and serine (S727) residues in epidermis.	Tetradecanoylphorbol Acetate	28-64	signal transducer and activator of transcription 1	Mus musculus	163-168
8035792-8	1994	EGR1 and EGR2 increased IL-3 promoter activity when the transfected cells were stimulated with phorbol-12-myristate-13-acetate and A23187.	Tetradecanoylphorbol Acetate	95-126	interleukin 3	Homo sapiens	24-28
8068181-2	1994	Using in situ hybridization techniques, we confirmed in this study the expression of ST-1 mRNA in mouse skin keratinocytes treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and also observed dramatic expression of ST-1 message in underlying fibroblastic cells.	Tetradecanoylphorbol Acetate	155-191	matrix metallopeptidase 3	Mus musculus	85-89
25818598-0	2015	Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-kappaB and MAPK activation in macrophages and TPA-induced ear edema in mice.	Tetradecanoylphorbol Acetate	118-121	carbonyl reductase 1	Mus musculus	4-8
8038217-5	1994	Phorbol-myristate acetate (PMA) inhibited EGF-dependent protein tyrosine phosphorylation, and when compared to melittin or calcium ionophore A23187, only PMA potentiated the EGF-induced tyrosine phosphorylation of two proteins immunologically related to mitogen activated protein (MAP) kinases of 40 kDa and 44 kDa molecular mass.	Tetradecanoylphorbol Acetate	0-25	epidermal growth factor	Mus musculus	42-45
25818598-6	2015	Furthermore, Tat-CBR1 protein inhibited inflammatory responses in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation when applied topically.	Tetradecanoylphorbol Acetate	66-102	carbonyl reductase 1	Mus musculus	17-21
25818598-6	2015	Furthermore, Tat-CBR1 protein inhibited inflammatory responses in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation when applied topically.	Tetradecanoylphorbol Acetate	104-107	carbonyl reductase 1	Mus musculus	17-21
25982116-3	2015	Phosphorylation of S226 is required for the rapid increase in glucose uptake and enhanced cell surface localization of GLUT1 induced by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	154-191	solute carrier family 2 member 1	Homo sapiens	119-124
8038217-5	1994	Phorbol-myristate acetate (PMA) inhibited EGF-dependent protein tyrosine phosphorylation, and when compared to melittin or calcium ionophore A23187, only PMA potentiated the EGF-induced tyrosine phosphorylation of two proteins immunologically related to mitogen activated protein (MAP) kinases of 40 kDa and 44 kDa molecular mass.	Tetradecanoylphorbol Acetate	0-25	epidermal growth factor	Mus musculus	174-177
8038217-5	1994	Phorbol-myristate acetate (PMA) inhibited EGF-dependent protein tyrosine phosphorylation, and when compared to melittin or calcium ionophore A23187, only PMA potentiated the EGF-induced tyrosine phosphorylation of two proteins immunologically related to mitogen activated protein (MAP) kinases of 40 kDa and 44 kDa molecular mass.	Tetradecanoylphorbol Acetate	27-30	epidermal growth factor	Mus musculus	42-45
8038217-5	1994	Phorbol-myristate acetate (PMA) inhibited EGF-dependent protein tyrosine phosphorylation, and when compared to melittin or calcium ionophore A23187, only PMA potentiated the EGF-induced tyrosine phosphorylation of two proteins immunologically related to mitogen activated protein (MAP) kinases of 40 kDa and 44 kDa molecular mass.	Tetradecanoylphorbol Acetate	154-157	epidermal growth factor	Mus musculus	174-177
7913409-3	1994	On stimulation with phytohemagglutinin and phorbol 12-myristate 13-acetate, transplant-derived peripheral blood mononuclear cells demonstrate statistically significant depressed production of interleukin 3 (IL-3), IL-4, granulocyte-macrophage-colony-stimulating factor, and gamma-interferon as compared to normal controls, during the first 6 months following engraftment, which recover to normal levels 6 months or more posttransplant.	Tetradecanoylphorbol Acetate	43-74	interleukin 3	Homo sapiens	192-211
25982116-3	2015	Phosphorylation of S226 is required for the rapid increase in glucose uptake and enhanced cell surface localization of GLUT1 induced by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	193-196	solute carrier family 2 member 1	Homo sapiens	119-124
25982116-4	2015	Endogenous GLUT1 is phosphorylated on S226 in primary endothelial cells in response to TPA or VEGF.	Tetradecanoylphorbol Acetate	87-90	solute carrier family 2 member 1	Homo sapiens	11-16
7913409-3	1994	On stimulation with phytohemagglutinin and phorbol 12-myristate 13-acetate, transplant-derived peripheral blood mononuclear cells demonstrate statistically significant depressed production of interleukin 3 (IL-3), IL-4, granulocyte-macrophage-colony-stimulating factor, and gamma-interferon as compared to normal controls, during the first 6 months following engraftment, which recover to normal levels 6 months or more posttransplant.	Tetradecanoylphorbol Acetate	43-74	colony stimulating factor 2	Homo sapiens	220-268
8027056-1	1994	We investigated the signal transduction pathways leading to the 12-O-tetradecanoylphorbol-13-acetate (TPA)- and interleukin-1 alpha (IL-1)-induced IL-1 alpha mRNA in mouse keratinocytes.	Tetradecanoylphorbol Acetate	64-100	interleukin 1 alpha	Mus musculus	147-157
25545227-8	2015	Here it is shown that NETs formation is strictly dependent on glucose and to a lesser extent on glutamine, that Glut-1, glucose uptake, and glycolysis rate increase upon PMA stimulation, and that NET formation is inhibited by the glycolysis inhibitor, 2-deoxy-glucose, and to a lesser extent by the ATP synthase inhibitor oligomycin.	Tetradecanoylphorbol Acetate	170-173	solute carrier family 2 member 1	Homo sapiens	112-118
25941985-4	2015	Treatment with CPT also downregulated phorbol-12-myristate-13-acetate (PMA)- and tumor necrosis factor-alpha (TNF-alpha)-induced MMP-9 and VEGF expression by inhibiting nuclear factor-kappaB (NF-kappaB) activity.	Tetradecanoylphorbol Acetate	38-69	matrix metallopeptidase 9	Homo sapiens	129-134
25941985-4	2015	Treatment with CPT also downregulated phorbol-12-myristate-13-acetate (PMA)- and tumor necrosis factor-alpha (TNF-alpha)-induced MMP-9 and VEGF expression by inhibiting nuclear factor-kappaB (NF-kappaB) activity.	Tetradecanoylphorbol Acetate	71-74	matrix metallopeptidase 9	Homo sapiens	129-134
8027056-1	1994	We investigated the signal transduction pathways leading to the 12-O-tetradecanoylphorbol-13-acetate (TPA)- and interleukin-1 alpha (IL-1)-induced IL-1 alpha mRNA in mouse keratinocytes.	Tetradecanoylphorbol Acetate	102-105	interleukin 1 alpha	Mus musculus	147-157
25941985-6	2015	We further confirmed that CPT inhibits PMA-induced MMP-9 and VEGF expression by upregulating nuclear factor-erythroid related factor-2 (Nrf2)-mediated heme oxygenase-1 (HO-1) induction.	Tetradecanoylphorbol Acetate	39-42	matrix metallopeptidase 9	Homo sapiens	51-56
8027056-2	1994	Induction of IL-1 alpha mRNA by TPA or IL-1 alpha was followed by increases in cell-associated IL-1 alpha protein measured by enzyme-linked immunosorbent assay.	Tetradecanoylphorbol Acetate	32-35	interleukin 1 alpha	Mus musculus	13-23
8027056-3	1994	Although protein kinase C (PKC) was involved in TPA-induced IL-1 alpha mRNA, down-regulation of PKC did not block the induction of this gene by TPA.	Tetradecanoylphorbol Acetate	48-51	interleukin 1 alpha	Mus musculus	60-70
8027056-8	1994	In addition, both TPA and IL-1 alpha caused increases not only in the phosphorylation of c-Jun and c-Fos protein but also in the transactivating activity of AP-1 nuclear transcription factor.	Tetradecanoylphorbol Acetate	18-21	FBJ osteosarcoma oncogene	Mus musculus	99-104
8027056-10	1994	This study suggests that the activation of AP-1 may be a common event through which TPA and IL-1 alpha induce IL-1 alpha mRNA.	Tetradecanoylphorbol Acetate	84-87	interleukin 1 alpha	Mus musculus	110-120
7947388-7	1994	TPA-induced LNCaP apoptosis was preceded by rapid yet transient induction of the early response transcription factors NGFI-A and c-fos.	Tetradecanoylphorbol Acetate	0-3	early growth response 1	Homo sapiens	118-124
25695860-5	2015	Cells were also treated with PMA to induce MMP-9 activity.	Tetradecanoylphorbol Acetate	29-32	matrix metallopeptidase 9	Homo sapiens	43-48
25666088-5	2015	Our aim of the present study is to investigate the pro-inflammatory cytokines and pattern of AP-1 factors expressed during activation of lung adenocarcinoma A549 cells by Phorbol-12-myristate-13-acetate (PMA) and to understand the anti-inflammatory effect of apigenin.	Tetradecanoylphorbol Acetate	171-202	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-97
7947388-9	1994	TPA-induced expression of NGFI-A and c-fos and death of LNCaP cultures were blocked by pretreatment with staurosporine, a potent inhibitor of several protein kinases.	Tetradecanoylphorbol Acetate	0-3	early growth response 1	Homo sapiens	26-32
25666088-5	2015	Our aim of the present study is to investigate the pro-inflammatory cytokines and pattern of AP-1 factors expressed during activation of lung adenocarcinoma A549 cells by Phorbol-12-myristate-13-acetate (PMA) and to understand the anti-inflammatory effect of apigenin.	Tetradecanoylphorbol Acetate	204-207	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-97
7947388-10	1994	Based on these studies, we suggest that activation of a TPA-inducible kinase(s) mediates apoptosis of androgen-sensitive prostate cells by means of an intracellular pathway that may involve the transient activation of the early response transcription factors NGFI-A and c-fos.	Tetradecanoylphorbol Acetate	56-59	early growth response 1	Homo sapiens	259-265
8020607-4	1994	Furthermore, activity of Ki-ras p21 2 h prior to TPA exposure enhanced the inhibitory effect of TPA in quiescent cells.	Tetradecanoylphorbol Acetate	49-52	H3 histone pseudogene 16	Homo sapiens	32-35
25670016-3	2015	We further show that glaucine significantly blocks phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression and activity in a dose-dependent manner.	Tetradecanoylphorbol Acetate	51-82	matrix metallopeptidase 9	Homo sapiens	97-102
25670016-3	2015	We further show that glaucine significantly blocks phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression and activity in a dose-dependent manner.	Tetradecanoylphorbol Acetate	84-87	matrix metallopeptidase 9	Homo sapiens	97-102
25348263-0	2015	Coordinated activation of AMP-activated protein kinase, extracellular signal-regulated kinase, and autophagy regulates phorbol myristate acetate-induced differentiation of SH-SY5Y neuroblastoma cells.	Tetradecanoylphorbol Acetate	119-144	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	26-54
8020607-4	1994	Furthermore, activity of Ki-ras p21 2 h prior to TPA exposure enhanced the inhibitory effect of TPA in quiescent cells.	Tetradecanoylphorbol Acetate	96-99	H3 histone pseudogene 16	Homo sapiens	32-35
8020607-6	1994	The suppression of junctional communication by TPA was completely prevented if the oncogenic p21 had been active for a longer period of time (48 h).	Tetradecanoylphorbol Acetate	47-50	H3 histone pseudogene 16	Homo sapiens	93-96
8020607-8	1994	From these results we conclude that there is a cell-state dependence of junctional sensitivity to TPA in NRK cells and that ras p21 activity potentiates the junctional response to TPA.	Tetradecanoylphorbol Acetate	180-183	H3 histone pseudogene 16	Homo sapiens	128-131
7947460-4	1994	Activation with antigen or TPA/anti-CD3 mAb of Th2 T cell clones that had been preincubated with rIL-12 and rIL-2 for 5 days induced or enhanced the expression of IFN-gamma transcripts, as well as the production of IFN-gamma by these cells.	Tetradecanoylphorbol Acetate	27-30	interleukin 2	Rattus norvegicus	108-113
24243709-7	2015	Phorbol 12-myristate 13-acetate (PMA) and ionomycin enhanced activity of NFAT1, reduced E-cadherin and alpha-catenin protein levels, and increased protein levels of N-cadherin and Vimentin.	Tetradecanoylphorbol Acetate	0-31	nuclear factor of activated T cells 1	Homo sapiens	73-78
7932377-9	1994	12-O-Tetradecanoylphorbol-13-acetate decreased the affinity of the receptor for EGF changing the dissociation constant from 1.8 to 3.9 nmol l-1.	Tetradecanoylphorbol Acetate	0-36	epidermal growth factor	Homo sapiens	80-83
24243709-7	2015	Phorbol 12-myristate 13-acetate (PMA) and ionomycin enhanced activity of NFAT1, reduced E-cadherin and alpha-catenin protein levels, and increased protein levels of N-cadherin and Vimentin.	Tetradecanoylphorbol Acetate	0-31	cadherin 2	Homo sapiens	165-175
24243709-7	2015	Phorbol 12-myristate 13-acetate (PMA) and ionomycin enhanced activity of NFAT1, reduced E-cadherin and alpha-catenin protein levels, and increased protein levels of N-cadherin and Vimentin.	Tetradecanoylphorbol Acetate	33-36	nuclear factor of activated T cells 1	Homo sapiens	73-78
24243709-7	2015	Phorbol 12-myristate 13-acetate (PMA) and ionomycin enhanced activity of NFAT1, reduced E-cadherin and alpha-catenin protein levels, and increased protein levels of N-cadherin and Vimentin.	Tetradecanoylphorbol Acetate	33-36	cadherin 2	Homo sapiens	165-175
8043196-0	1994	Transforming growth factor-alpha expression in peritoneal macrophages elicited from SENCAR and B6C3F1 mice: responses to lipopolysaccharide and 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	144-180	transforming growth factor alpha	Mus musculus	0-32
25973018-12	2015	BCG induced HMGB1, IL-6, IL-10 and TNF-alpha production effectively in PMA-treated THP-1 cells.	Tetradecanoylphorbol Acetate	71-74	interleukin 10	Homo sapiens	25-30
8043196-2	1994	We hypothesized a similar strain-dependent secretion of transforming growth factor-alpha (TGF-alpha) by TPA-stimulated MPs.	Tetradecanoylphorbol Acetate	104-107	transforming growth factor alpha	Mus musculus	56-88
8043196-2	1994	We hypothesized a similar strain-dependent secretion of transforming growth factor-alpha (TGF-alpha) by TPA-stimulated MPs.	Tetradecanoylphorbol Acetate	104-107	transforming growth factor alpha	Mus musculus	90-99
8043196-6	1994	Although significant amounts of TGF-alpha could be detected in both SENCAR- and B6C3F1-derived MPs (i.e., approximately 2-3 ng/5 x 10(6) cells), SENCAR MPs did not secrete TGF-alpha in response to either TPA or LPS.	Tetradecanoylphorbol Acetate	204-207	transforming growth factor alpha	Mus musculus	32-41
8090283-2	1994	Previously we demonstrated that the synthetic diacylglycerol, phorbol 12-myristate 13-acetate (PMA) and PLC mimic the stimulatory effects of GnRH on both luteinizing hormone (LH) glycosylation and release.	Tetradecanoylphorbol Acetate	62-93	gonadotropin releasing hormone 1	Rattus norvegicus	141-145
24008983-0	2015	Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway.	Tetradecanoylphorbol Acetate	13-49	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	144-147
24008983-7	2015	We also determined that activator protein 1 (AP1) family member c-Fos mediated TPA activation of the 4.2 kb WF Fbxo10 promoter.	Tetradecanoylphorbol Acetate	79-82	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	24-43
24008983-7	2015	We also determined that activator protein 1 (AP1) family member c-Fos mediated TPA activation of the 4.2 kb WF Fbxo10 promoter.	Tetradecanoylphorbol Acetate	79-82	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-48
24008983-7	2015	We also determined that activator protein 1 (AP1) family member c-Fos mediated TPA activation of the 4.2 kb WF Fbxo10 promoter.	Tetradecanoylphorbol Acetate	79-82	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	64-69
25079913-3	2015	CCK (0.3, 100 nM) and TPA (1 muM) activated SFK and altered the activation of FAK proteins (PYK2, p125(FAK)), adaptor proteins (p130(CAS), paxillin), MAPK (p42/44, JNK, p38), Shc, PKC (PKD, MARCKS), Akt but not GSK3-beta.	Tetradecanoylphorbol Acetate	22-25	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	44-47
8090283-2	1994	Previously we demonstrated that the synthetic diacylglycerol, phorbol 12-myristate 13-acetate (PMA) and PLC mimic the stimulatory effects of GnRH on both luteinizing hormone (LH) glycosylation and release.	Tetradecanoylphorbol Acetate	95-98	gonadotropin releasing hormone 1	Rattus norvegicus	141-145
25079913-3	2015	CCK (0.3, 100 nM) and TPA (1 muM) activated SFK and altered the activation of FAK proteins (PYK2, p125(FAK)), adaptor proteins (p130(CAS), paxillin), MAPK (p42/44, JNK, p38), Shc, PKC (PKD, MARCKS), Akt but not GSK3-beta.	Tetradecanoylphorbol Acetate	22-25	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	133-136
7974383-2	1994	To clarify the mechanism, PAI-2 gene expression induced by phorbol myristate acetate (PMA), a PKC activator, and Bt2cAMP was investigated by Northern blot hybridization using a PAI-2 cDNA probe cloned from a human placental library.	Tetradecanoylphorbol Acetate	59-84	serpin family B member 2	Homo sapiens	26-31
25079913-3	2015	CCK (0.3, 100 nM) and TPA (1 muM) activated SFK and altered the activation of FAK proteins (PYK2, p125(FAK)), adaptor proteins (p130(CAS), paxillin), MAPK (p42/44, JNK, p38), Shc, PKC (PKD, MARCKS), Akt but not GSK3-beta.	Tetradecanoylphorbol Acetate	22-25	protein kinase C, gamma	Rattus norvegicus	180-183
25079913-3	2015	CCK (0.3, 100 nM) and TPA (1 muM) activated SFK and altered the activation of FAK proteins (PYK2, p125(FAK)), adaptor proteins (p130(CAS), paxillin), MAPK (p42/44, JNK, p38), Shc, PKC (PKD, MARCKS), Akt but not GSK3-beta.	Tetradecanoylphorbol Acetate	22-25	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	190-196
7974383-2	1994	To clarify the mechanism, PAI-2 gene expression induced by phorbol myristate acetate (PMA), a PKC activator, and Bt2cAMP was investigated by Northern blot hybridization using a PAI-2 cDNA probe cloned from a human placental library.	Tetradecanoylphorbol Acetate	86-89	serpin family B member 2	Homo sapiens	26-31
25479224-9	2014	In the nasal epithelial cells of patients with allergic rhinitis, EGCG significantly decreased phorbol 12-myristate 13-acetate (PMA)-induced MUC5B and MMP-9 expression.	Tetradecanoylphorbol Acetate	95-126	matrix metallopeptidase 9	Homo sapiens	151-156
25479224-9	2014	In the nasal epithelial cells of patients with allergic rhinitis, EGCG significantly decreased phorbol 12-myristate 13-acetate (PMA)-induced MUC5B and MMP-9 expression.	Tetradecanoylphorbol Acetate	128-131	matrix metallopeptidase 9	Homo sapiens	151-156
7974383-10	1994	The cells pretreated with PMA for 24 h did not any more respond to stimulation with PMA but responded to cAMP and PAI-2 mRNA level was increased.	Tetradecanoylphorbol Acetate	26-29	serpin family B member 2	Homo sapiens	114-119
7974383-11	1994	The apparent half-life of constitutive level PAI-2 mRNA in PL-21 cells, determined by actinomycin-D-decay experiments, was approximately 2 h. Those induced by PMA and cAMP were approximately 5 h and 2 h, respectively.	Tetradecanoylphorbol Acetate	159-162	serpin family B member 2	Homo sapiens	45-50
7975181-0	1994	Down-regulation followed by re-expression of equine CD4 molecules in response to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	81-106	CD4 molecule	Equus caballus	52-55
7975181-1	1994	The regulatory effects of phorbol myristate acetate (PMA) on the expression of the CD4 molecule on horse T cells were investigated.	Tetradecanoylphorbol Acetate	26-51	CD4 molecule	Equus caballus	83-86
7975181-1	1994	The regulatory effects of phorbol myristate acetate (PMA) on the expression of the CD4 molecule on horse T cells were investigated.	Tetradecanoylphorbol Acetate	53-56	CD4 molecule	Equus caballus	83-86
7975181-3	1994	Over 75% of the surface CD4 molecules per cell were lost after a 4 h exposure to PMA at 37 degrees C. The regulation of equine CD4 expression induced by PMA was temperature dependent and reversible.	Tetradecanoylphorbol Acetate	81-84	CD4 molecule	Equus caballus	24-27
25375862-9	2014	The ability of CPAF to suppress acute and chronic inflammatory changes in response to PMA application(s) was PAF-R dependent, as CPAF had no effect on basal or PMA-induced inflammation in Ptafr-/- mice.	Tetradecanoylphorbol Acetate	86-89	platelet-activating factor receptor	Mus musculus	109-114
7975181-3	1994	Over 75% of the surface CD4 molecules per cell were lost after a 4 h exposure to PMA at 37 degrees C. The regulation of equine CD4 expression induced by PMA was temperature dependent and reversible.	Tetradecanoylphorbol Acetate	81-84	CD4 molecule	Equus caballus	127-130
8204886-3	1994	The induction of IL-5 mRNA by phorbol 12-myristate 13-acetate (PMA) stimulation was found to be cyclosporin A-resistant, in contrast to the induction of IL-2 and GM-CSF mRNAs.	Tetradecanoylphorbol Acetate	30-61	interleukin 5	Mus musculus	17-21
25282183-1	2014	BACKGROUND: Matrix metalloproteinase-9 (MMP-9) plays a key role for the blood-brain barrier disruption and intravenous tissue plasminogen activator (iv-tPA) therapy increases MMP-9.	Tetradecanoylphorbol Acetate	152-155	matrix metallopeptidase 9	Homo sapiens	12-38
8204886-3	1994	The induction of IL-5 mRNA by phorbol 12-myristate 13-acetate (PMA) stimulation was found to be cyclosporin A-resistant, in contrast to the induction of IL-2 and GM-CSF mRNAs.	Tetradecanoylphorbol Acetate	63-66	interleukin 5	Mus musculus	17-21
25282183-1	2014	BACKGROUND: Matrix metalloproteinase-9 (MMP-9) plays a key role for the blood-brain barrier disruption and intravenous tissue plasminogen activator (iv-tPA) therapy increases MMP-9.	Tetradecanoylphorbol Acetate	152-155	matrix metallopeptidase 9	Homo sapiens	40-45
25282183-1	2014	BACKGROUND: Matrix metalloproteinase-9 (MMP-9) plays a key role for the blood-brain barrier disruption and intravenous tissue plasminogen activator (iv-tPA) therapy increases MMP-9.	Tetradecanoylphorbol Acetate	152-155	matrix metallopeptidase 9	Homo sapiens	175-180
8199198-3	1994	Binding activity of 125I-M-CSF to THP-1 cells was higher than that in THP-1 cells elicited with TPA.	Tetradecanoylphorbol Acetate	96-99	colony stimulating factor 1	Homo sapiens	25-30
25282183-3	2014	We aimed to investigate whether edaravone would suppress the MMP-9 increase after iv-tPA using low-dose alteplase (0.6 mg/kg).	Tetradecanoylphorbol Acetate	85-88	matrix metallopeptidase 9	Homo sapiens	61-66
8199198-4	1994	THP-1 cells incubated with M-CSF before TPA treatment were designated MT macrophages, and those incubated with M-CSF after TPA treatment were called TM macrophages.	Tetradecanoylphorbol Acetate	123-126	colony stimulating factor 1	Homo sapiens	111-116
7515343-8	1994	Thus, CD4+, Leu-8+ T cells from patients with PBC have a defect of proliferation and suppressor function that is reversed by coculture with PMA.	Tetradecanoylphorbol Acetate	140-143	selectin L	Homo sapiens	12-17
25150527-9	2014	RESULTS: All oils/fats showed topic anti-inflammatory activity, with better effect in the TPA-induced mice ear edema assay.	Tetradecanoylphorbol Acetate	90-93	DNA segment, Chr 7, ERATO Doi 443, expressed	Mus musculus	18-22
24909729-4	2014	In A549 cells, phorbol 12-myristate 13-acetate (PMA) treatment induced upregulation of COX-2 and MRP4 together, but not other MRP transporters.	Tetradecanoylphorbol Acetate	15-46	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	97-100
24909729-4	2014	In A549 cells, phorbol 12-myristate 13-acetate (PMA) treatment induced upregulation of COX-2 and MRP4 together, but not other MRP transporters.	Tetradecanoylphorbol Acetate	48-51	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	97-100
7925714-6	1994	Hyperactivation of protein kinase C by treatment of retinas with phorbol myristate acetate resulted in the phosphorylation of vimentin in situ, indicating that the phosphorylation is physiologically relevant.	Tetradecanoylphorbol Acetate	65-90	vimentin	Homo sapiens	126-134
8089198-5	1994	At 3 h after the treatment of the cells with H-7 and TPA, vitamin D receptor (VDR) contents estimated by 3H-1,25(OH)2D3 binding capacity were 72.4 and 63.2% of vehicle-treated cells without significant changes of binding affinities, suggesting that the effect of H-7 and TPA was not the result of changes in VDR content or its binding affinity.	Tetradecanoylphorbol Acetate	53-56	vitamin D receptor	Rattus norvegicus	58-76
25036403-0	2014	Annexin A3 plays a role in cytoplasmic calcium oscillation by extracellular calcium in the human promyelocytic leukemia HL-60 cells differentiated by phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	150-181	annexin A3	Homo sapiens	0-10
8089198-5	1994	At 3 h after the treatment of the cells with H-7 and TPA, vitamin D receptor (VDR) contents estimated by 3H-1,25(OH)2D3 binding capacity were 72.4 and 63.2% of vehicle-treated cells without significant changes of binding affinities, suggesting that the effect of H-7 and TPA was not the result of changes in VDR content or its binding affinity.	Tetradecanoylphorbol Acetate	53-56	vitamin D receptor	Rattus norvegicus	78-81
24742714-10	2014	The above findings, taken together, suggest that genistein inhibits TPA-induced COX-2 expression in MCF10A cells by blocking ERK-mediated phosphorylation of p65 and its subsequent interaction with CBP and TBP.	Tetradecanoylphorbol Acetate	68-71	TATA-box binding protein	Homo sapiens	205-208
25915883-12	2015	Treatment with PKC-activating agent phorbol-12-myristate-13-acetate attenuated exendin-4-induced relaxations and reduced GLP-1R expression in WKY arteries, which were reversed by GFX, Go6976, or hispidin.	Tetradecanoylphorbol Acetate	36-67	protein kinase C, alpha	Rattus norvegicus	15-18
8089198-5	1994	At 3 h after the treatment of the cells with H-7 and TPA, vitamin D receptor (VDR) contents estimated by 3H-1,25(OH)2D3 binding capacity were 72.4 and 63.2% of vehicle-treated cells without significant changes of binding affinities, suggesting that the effect of H-7 and TPA was not the result of changes in VDR content or its binding affinity.	Tetradecanoylphorbol Acetate	53-56	vitamin D receptor	Rattus norvegicus	308-311
25915883-12	2015	Treatment with PKC-activating agent phorbol-12-myristate-13-acetate attenuated exendin-4-induced relaxations and reduced GLP-1R expression in WKY arteries, which were reversed by GFX, Go6976, or hispidin.	Tetradecanoylphorbol Acetate	36-67	glucagon-like peptide 1 receptor	Rattus norvegicus	121-127
25241044-8	2014	Furthermore, curcumin reversed PMA stimulated PKC activation and suppressed the chronic activation of AMPK, which in turn reduced the expression of MMP-9, MMP-13 and EMMPRIN.	Tetradecanoylphorbol Acetate	31-34	matrix metallopeptidase 9	Homo sapiens	148-153
8089198-5	1994	At 3 h after the treatment of the cells with H-7 and TPA, vitamin D receptor (VDR) contents estimated by 3H-1,25(OH)2D3 binding capacity were 72.4 and 63.2% of vehicle-treated cells without significant changes of binding affinities, suggesting that the effect of H-7 and TPA was not the result of changes in VDR content or its binding affinity.	Tetradecanoylphorbol Acetate	271-274	vitamin D receptor	Rattus norvegicus	78-81
8183547-2	1994	Addition of the tumor promoter, phorbol myristate acetate (PMA), prevents apoptotic cell death induced by low serum concentrations in NIH3T3 cells that constitutively express and are transformed by v-myc.	Tetradecanoylphorbol Acetate	32-57	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	200-203
24961879-2	2014	Here, we show that leukocytic Runx3 expression is central to the two-stage DMBA/TPA-induced skin tumorigenesis.	Tetradecanoylphorbol Acetate	80-83	runt related transcription factor 3	Mus musculus	30-35
25301262-6	2015	EGFR and AKT phosphorylation was enhanced by stimulation with the ADAM17 agonist chemokine phorbol myristate acetate.	Tetradecanoylphorbol Acetate	91-116	ADAM metallopeptidase domain 17	Homo sapiens	66-72
25447204-5	2015	A novel FFAT (two phenylalanines in an acidic tract)-like motif was identified in ORP3; only disruption of both the FFAT-like and canonical FFAT motif abolished the phorbol-12-myristate-13-acetate (PMA) stimulated interaction of ORP3-P with VAPA.	Tetradecanoylphorbol Acetate	165-196	oxysterol binding protein like 3	Homo sapiens	82-86
7514103-6	1994	When the sIg stimulation of B cells was mimicked by the costimulation with 12-O-tetradecanoylphorbol 13-acetate and ionomycin, H2-c-fos B cells required higher concentrations of ionomycin for the optimal proliferative responses, suggesting that calcium-dependent signal transduction pathways are disturbed in those B cells.	Tetradecanoylphorbol Acetate	75-111	FBJ osteosarcoma oncogene	Mus musculus	130-135
25447204-5	2015	A novel FFAT (two phenylalanines in an acidic tract)-like motif was identified in ORP3; only disruption of both the FFAT-like and canonical FFAT motif abolished the phorbol-12-myristate-13-acetate (PMA) stimulated interaction of ORP3-P with VAPA.	Tetradecanoylphorbol Acetate	165-196	oxysterol binding protein like 3	Homo sapiens	229-235
25447204-5	2015	A novel FFAT (two phenylalanines in an acidic tract)-like motif was identified in ORP3; only disruption of both the FFAT-like and canonical FFAT motif abolished the phorbol-12-myristate-13-acetate (PMA) stimulated interaction of ORP3-P with VAPA.	Tetradecanoylphorbol Acetate	198-201	oxysterol binding protein like 3	Homo sapiens	82-86
24956535-10	2014	In multiple regression analysis, RBP4 (beta = 0.232, p = 0.025) and hsCRP (beta = 0.300, p = 0.004) emerged as independent determinants of TPA in patients with carotid atherosclerosis.	Tetradecanoylphorbol Acetate	139-142	retinol binding protein 4	Homo sapiens	33-37
8185825-0	1994	Epidermal expression of transforming growth factor-alpha in transgenic mice: induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression.	Tetradecanoylphorbol Acetate	106-142	transforming growth factor alpha	Mus musculus	24-56
25663523-4	2015	Increased expression of PAR-4, but not other PARs, was observed in fibroblasts stimulated with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	95-120	F2R like thrombin or trypsin receptor 3	Homo sapiens	24-29
8185825-2	1994	We observed that HK1.TGF alpha mice were highly sensitive to TPA promotion, exhibiting multiple papillomas as early as the third week of treatment.	Tetradecanoylphorbol Acetate	61-64	transforming growth factor alpha	Mus musculus	21-30
24780839-8	2014	In conclusion, PMA exerted its anti-cancer effects via the activation of pro-apoptotic JNK/p53 and inhibition of pro-proliferative E2F1/AR in prostate cancer cells including CRPC cells.	Tetradecanoylphorbol Acetate	15-18	tumor protein p53 L homeolog	Xenopus laevis	91-94
8185825-6	1994	Both spontaneous and TPA-induced HK1.TGF alpha papillomas expressed c-Ha-ras message levels similar to those in normal, nontransgenic epidermis or HK1.TGF alpha hyperplastic epidermis.	Tetradecanoylphorbol Acetate	21-24	transforming growth factor alpha	Mus musculus	37-46
25453494-6	2015	Moreover, kaempferol repressed phorbol-12-myristate-13-acetate (PMA)-induced MMP-9 expression and activity through suppressing the translocation of protein kinase Cdelta (PKCdelta) and MAPK signaling pathway.	Tetradecanoylphorbol Acetate	31-62	matrix metallopeptidase 9	Homo sapiens	77-82
8185825-6	1994	Both spontaneous and TPA-induced HK1.TGF alpha papillomas expressed c-Ha-ras message levels similar to those in normal, nontransgenic epidermis or HK1.TGF alpha hyperplastic epidermis.	Tetradecanoylphorbol Acetate	21-24	POC1 centriolar protein A	Mus musculus	68-72
25453494-6	2015	Moreover, kaempferol repressed phorbol-12-myristate-13-acetate (PMA)-induced MMP-9 expression and activity through suppressing the translocation of protein kinase Cdelta (PKCdelta) and MAPK signaling pathway.	Tetradecanoylphorbol Acetate	64-67	matrix metallopeptidase 9	Homo sapiens	77-82
8185825-6	1994	Both spontaneous and TPA-induced HK1.TGF alpha papillomas expressed c-Ha-ras message levels similar to those in normal, nontransgenic epidermis or HK1.TGF alpha hyperplastic epidermis.	Tetradecanoylphorbol Acetate	21-24	transforming growth factor alpha	Mus musculus	151-160
24859472-4	2014	The results revealed that 12-O-tetradecanoylphorbol-13-acetate-induced increases in COX-2 and MMP-9 expression levels were reversed by proton beam irradiation in a dose-dependent manner.	Tetradecanoylphorbol Acetate	26-62	matrix metallopeptidase 9	Homo sapiens	94-99
8185825-7	1994	These data demonstrate that TGF-alpha overexpression can be an initiating event for TPA promotion, that papillomatogenesis in HK1.TGF alpha mice proceeds frequently via a pathway independent of Ha-ras activation or overexpression, and, thus, that other events are required for autonomous growth and malignant conversion.	Tetradecanoylphorbol Acetate	84-87	transforming growth factor alpha	Mus musculus	28-37
8190100-4	1994	Similarly, cAMP accumulation was enhanced by coincubation with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	100-131	protein kinase C epsilon	Homo sapiens	85-88
24753227-4	2014	The 12-O-tetradecanoylphorbol-13-acetate-responsive element, a binding site for c-Jun and c-Fos, was identified as resveratrol-responsive element.	Tetradecanoylphorbol Acetate	4-40	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-85
25533502-5	2015	Moreover, butein abolished TNF-alpha- and PMA-induced IkappaBalpha phosphorylation, which participates in NF-kappaB activation, and PMA-induced phosphorylation of c-Jun, a subunit composed of AP-1.	Tetradecanoylphorbol Acetate	42-45	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	192-196
25533502-6	2015	In vitro, butein inhibited the phosphorylation of c-Jun, binding to GST beads, mediated by JNK isolated from PMA-treated cells.	Tetradecanoylphorbol Acetate	109-112	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-55
24753227-4	2014	The 12-O-tetradecanoylphorbol-13-acetate-responsive element, a binding site for c-Jun and c-Fos, was identified as resveratrol-responsive element.	Tetradecanoylphorbol Acetate	4-40	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-95
8190100-4	1994	Similarly, cAMP accumulation was enhanced by coincubation with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187.	Tetradecanoylphorbol Acetate	133-136	protein kinase C epsilon	Homo sapiens	85-88
8190100-5	1994	After exposure to PMA for 24 hr (PKC-depleted cells), 5-HT and A23187 still enhanced cAMP formed in response to forskolin and 5"-N-ethylcarboxamidoadenosine, whereas the amplifying effects of PMA were abolished.	Tetradecanoylphorbol Acetate	18-21	protein kinase C epsilon	Homo sapiens	33-36
25559824-11	2015	Finally, PMA + ionomycin stimulation did not induce significant alterations on MSCs phenotype but did increase indoleamine-2,3-dioxygenase (IDO), inducible costimulatory ligand (ICOSL), IL-1beta, IL-8, and TNF-alpha mRNA expression.	Tetradecanoylphorbol Acetate	9-12	inducible T cell costimulator ligand	Homo sapiens	178-183
9397948-2	1994	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) resulted in a time- and dose-dependent increase in VDR expression in ROS cells.	Tetradecanoylphorbol Acetate	23-54	vitamin D receptor	Rattus norvegicus	112-115
24486723-8	2014	In addition, MED significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced CCA cells invasion in a dose-dependent manner by reducing the expression of matrix metalloelastase 9 (MMP-9).	Tetradecanoylphorbol Acetate	79-82	matrix metallopeptidase 9	Homo sapiens	194-199
9397948-2	1994	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) resulted in a time- and dose-dependent increase in VDR expression in ROS cells.	Tetradecanoylphorbol Acetate	56-59	vitamin D receptor	Rattus norvegicus	112-115
24789371-4	2014	We found that shikonin inhibited phorbol 12-myristate 13-acetate (PMA)-induced cell migration and invasion in MCF-7 breast cancer cells, which was correlated with modulation of matrix metalloproteinase-9 (MMP-9) through suppression of both expression and proteolytic and promoter activity.	Tetradecanoylphorbol Acetate	33-64	matrix metallopeptidase 9	Homo sapiens	177-203
26510981-7	2015	Pharmacological inhibition of ceramidase activity or activation PKC activity with 12-myristate 13-acetate (PMA) or diacylglycerol (DAG) decreased endogenous APP mRNA levels in ABCA2 overexpressing cells.	Tetradecanoylphorbol Acetate	107-110	ATP binding cassette subfamily A member 2	Homo sapiens	176-181
9397948-8	1994	PMA treatment alone resulted in a 50% increase in VDR protein and a marginal 20% increase in VDR mRNA.	Tetradecanoylphorbol Acetate	0-3	vitamin D receptor	Rattus norvegicus	50-53
9397948-8	1994	PMA treatment alone resulted in a 50% increase in VDR protein and a marginal 20% increase in VDR mRNA.	Tetradecanoylphorbol Acetate	0-3	vitamin D receptor	Rattus norvegicus	93-96
25403261-8	2015	Moreover, we stimulated the chicken spleen cells with phorbol 12-myristate 13-acetate (PMA) and ionomycin aiming at the induction of immunoproteasome, but in spite of the induction of proliferation and IFN-gamma, no evidence for immunoproteasome formation in chicken could be obtained.	Tetradecanoylphorbol Acetate	87-90	interferon gamma	Gallus gallus	202-211
9397949-6	1994	In addition to estrogen, epidermal growth factor (EGF) and tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) can also induce c-myc expression with no effect on c-fos or lactoferrin expression.	Tetradecanoylphorbol Acetate	74-110	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	133-138
9397949-6	1994	In addition to estrogen, epidermal growth factor (EGF) and tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) can also induce c-myc expression with no effect on c-fos or lactoferrin expression.	Tetradecanoylphorbol Acetate	112-115	epidermal growth factor	Homo sapiens	25-48
9397949-6	1994	In addition to estrogen, epidermal growth factor (EGF) and tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) can also induce c-myc expression with no effect on c-fos or lactoferrin expression.	Tetradecanoylphorbol Acetate	112-115	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	133-138
24789371-4	2014	We found that shikonin inhibited phorbol 12-myristate 13-acetate (PMA)-induced cell migration and invasion in MCF-7 breast cancer cells, which was correlated with modulation of matrix metalloproteinase-9 (MMP-9) through suppression of both expression and proteolytic and promoter activity.	Tetradecanoylphorbol Acetate	33-64	matrix metallopeptidase 9	Homo sapiens	205-210
24789371-4	2014	We found that shikonin inhibited phorbol 12-myristate 13-acetate (PMA)-induced cell migration and invasion in MCF-7 breast cancer cells, which was correlated with modulation of matrix metalloproteinase-9 (MMP-9) through suppression of both expression and proteolytic and promoter activity.	Tetradecanoylphorbol Acetate	66-69	matrix metallopeptidase 9	Homo sapiens	177-203
25845382-4	2015	Proton beam irradiation inhibited the increase in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced integrin beta1 protein expression and the gene expression of members of the integrin family, such as alpha5beta1, alpha6beta4, alphavbeta3, and alphavbeta6 in human colorectal adenocarcinoma HT-29 cells.	Tetradecanoylphorbol Acetate	50-86	integrin subunit beta 1	Homo sapiens	101-115
8157658-2	1994	Dissociation of L-hsp27 to S-hsp27 was enhanced by incubation of cells with phorbol 12-myristate-13 acetate, interleukin-1 alpha, tumor necrosis factor alpha, or okadaic acid, all of which are known to enhance or mimic the effects of phosphorylation of hsp27 without stimulation of its synthesis.	Tetradecanoylphorbol Acetate	76-107	heat shock protein family B (small) member 1	Homo sapiens	18-23
25845382-4	2015	Proton beam irradiation inhibited the increase in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced integrin beta1 protein expression and the gene expression of members of the integrin family, such as alpha5beta1, alpha6beta4, alphavbeta3, and alphavbeta6 in human colorectal adenocarcinoma HT-29 cells.	Tetradecanoylphorbol Acetate	88-91	integrin subunit beta 1	Homo sapiens	101-115
24789371-4	2014	We found that shikonin inhibited phorbol 12-myristate 13-acetate (PMA)-induced cell migration and invasion in MCF-7 breast cancer cells, which was correlated with modulation of matrix metalloproteinase-9 (MMP-9) through suppression of both expression and proteolytic and promoter activity.	Tetradecanoylphorbol Acetate	66-69	matrix metallopeptidase 9	Homo sapiens	205-210
8157658-2	1994	Dissociation of L-hsp27 to S-hsp27 was enhanced by incubation of cells with phorbol 12-myristate-13 acetate, interleukin-1 alpha, tumor necrosis factor alpha, or okadaic acid, all of which are known to enhance or mimic the effects of phosphorylation of hsp27 without stimulation of its synthesis.	Tetradecanoylphorbol Acetate	76-107	heat shock protein family B (small) member 1	Homo sapiens	29-34
24859347-0	2014	The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin.	Tetradecanoylphorbol Acetate	121-124	sirtuin 1	Homo sapiens	64-69
27057553-5	2015	MSU crystals, PMA, and H2O2 induced the release of S100A8, S100A9, and S100A12 homodimers, as well as S100A8/A9 heterodimer.	Tetradecanoylphorbol Acetate	14-17	S100 calcium binding protein A9	Homo sapiens	59-65
8157658-2	1994	Dissociation of L-hsp27 to S-hsp27 was enhanced by incubation of cells with phorbol 12-myristate-13 acetate, interleukin-1 alpha, tumor necrosis factor alpha, or okadaic acid, all of which are known to enhance or mimic the effects of phosphorylation of hsp27 without stimulation of its synthesis.	Tetradecanoylphorbol Acetate	76-107	heat shock protein family B (small) member 1	Homo sapiens	29-34
8144618-4	1994	Like in man and rat, the expressions of collagenase I, stromelysin-1, and stromelysin-2 are regulated by the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate and by UV irradiation, but not by cAMP.	Tetradecanoylphorbol Acetate	124-161	matrix metallopeptidase 10	Rattus norvegicus	74-87
25518925-2	2015	In this study, we analyzed the effect of flavonols on MMP-9 expression in phorbol-12-myristate-13-acetate (PMA)-induced human fibrosarcoma HT-1080 cells.	Tetradecanoylphorbol Acetate	74-105	matrix metallopeptidase 9	Homo sapiens	54-59
24796531-6	2014	c-Jun increased expression of SPPR3 mainly via a PKC/JNK pathway in response to TPA in KYSE450 cells.	Tetradecanoylphorbol Acetate	80-83	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
8178955-6	1994	We estimated the Na-H exchange flux (JNa-H) as the difference JTotal-JEIPA/R-CGRP, forskolin, and PMA produced similar increases in the slope of the JNa-H vs. pHi-relationship.	Tetradecanoylphorbol Acetate	98-101	glucose-6-phosphate isomerase	Rattus norvegicus	159-162
25518925-2	2015	In this study, we analyzed the effect of flavonols on MMP-9 expression in phorbol-12-myristate-13-acetate (PMA)-induced human fibrosarcoma HT-1080 cells.	Tetradecanoylphorbol Acetate	107-110	matrix metallopeptidase 9	Homo sapiens	54-59
8054453-2	1994	The mechanism and kinetics of TF mRNA and TF activity induction in human peripheral blood monocytes (HPBM) in response to bacterial lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) were investigated.	Tetradecanoylphorbol Acetate	161-186	coagulation factor III, tissue factor	Homo sapiens	30-32
25489104-3	2014	Here we report that mice lacking DUSP5 show a greatly increased sensitivity to mutant Harvey-Ras (HRas(Q61L))-driven papilloma formation in the 7,12-Dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA) model of skin carcinogenesis.	Tetradecanoylphorbol Acetate	175-211	Harvey rat sarcoma virus oncogene	Mus musculus	86-96
24604087-0	2014	Decursin prevents TPA-induced invasion through suppression of PKCalpha/p38/NF-kappaB-dependent MMP-9 expression in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	18-21	matrix metallopeptidase 9	Homo sapiens	95-100
24604087-5	2014	Therefore, in this study, we investigated the inhibitory effect of decursin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion, as well as the molecular mechanisms involved in MCF-7 cells.	Tetradecanoylphorbol Acetate	79-115	matrix metallopeptidase 9	Homo sapiens	130-135
24604087-5	2014	Therefore, in this study, we investigated the inhibitory effect of decursin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion, as well as the molecular mechanisms involved in MCF-7 cells.	Tetradecanoylphorbol Acetate	117-120	matrix metallopeptidase 9	Homo sapiens	130-135
24604087-6	2014	Our results showed that decursin inhibits TPA-induced MMP-9 expression and cell invasion through the suppression of NF-kappaB.	Tetradecanoylphorbol Acetate	42-45	matrix metallopeptidase 9	Homo sapiens	54-59
8054453-2	1994	The mechanism and kinetics of TF mRNA and TF activity induction in human peripheral blood monocytes (HPBM) in response to bacterial lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) were investigated.	Tetradecanoylphorbol Acetate	188-191	coagulation factor III, tissue factor	Homo sapiens	30-32
25280942-3	2014	Upon stimulating IL-32theta-expressing THP-1 cells with phorbol myristate acetate (PMA), we found that the CCL5 transcript level was significantly reduced.	Tetradecanoylphorbol Acetate	56-81	C-C motif chemokine ligand 5	Homo sapiens	107-111
8054453-2	1994	The mechanism and kinetics of TF mRNA and TF activity induction in human peripheral blood monocytes (HPBM) in response to bacterial lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) were investigated.	Tetradecanoylphorbol Acetate	188-191	coagulation factor III, tissue factor	Homo sapiens	42-44
25280942-3	2014	Upon stimulating IL-32theta-expressing THP-1 cells with phorbol myristate acetate (PMA), we found that the CCL5 transcript level was significantly reduced.	Tetradecanoylphorbol Acetate	83-86	C-C motif chemokine ligand 5	Homo sapiens	107-111
8054453-3	1994	Northern blot analysis showed that both LPS and PMA induce a transient accumulation of TF mRNA in HPBM, that reaches maximum levels after 3-6 h and rapidly declines thereafter.	Tetradecanoylphorbol Acetate	48-51	coagulation factor III, tissue factor	Homo sapiens	87-89
8005230-7	1994	The PKC activator phorbol myristate acetate (PMA) not only induced luciferase activity by itself but enhanced the action of Epo.	Tetradecanoylphorbol Acetate	18-43	erythropoietin	Mus musculus	124-127
25043383-8	2014	More importantly, we observed that subpicomolar DPI inhibited phorbol myristate acetate (PMA)-induced activation of NOX2.	Tetradecanoylphorbol Acetate	62-87	cytochrome b-245 beta chain	Homo sapiens	116-120
25043383-8	2014	More importantly, we observed that subpicomolar DPI inhibited phorbol myristate acetate (PMA)-induced activation of NOX2.	Tetradecanoylphorbol Acetate	89-92	cytochrome b-245 beta chain	Homo sapiens	116-120
25132928-5	2014	METHODS: Human AF (hAF) pellet was co-cultured for 48 hours with phorbol myristate acetate-stimulated macrophage-like THP-1 cells.	Tetradecanoylphorbol Acetate	65-90	coagulation factor XII	Homo sapiens	15-17
25132928-5	2014	METHODS: Human AF (hAF) pellet was co-cultured for 48 hours with phorbol myristate acetate-stimulated macrophage-like THP-1 cells.	Tetradecanoylphorbol Acetate	65-90	coagulation factor XII	Homo sapiens	19-22
8005230-7	1994	The PKC activator phorbol myristate acetate (PMA) not only induced luciferase activity by itself but enhanced the action of Epo.	Tetradecanoylphorbol Acetate	45-48	erythropoietin	Mus musculus	124-127
24733900-7	2014	Intrabody expression did not affect the overall accumulation of pSSTAT3 induced by interleukin-6 or phorbol 12-myristate 13-acetate (PMA), the PMA-induced expression of the c-Fos gene, or the PMA-induced accumulation of pSSTAT3 specifically in mitochondria.	Tetradecanoylphorbol Acetate	143-146	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	173-178
8005230-8	1994	On the other hand, the PKC inhibitor 1-(5-isoquinolynyl-sulfonyl)-2-methylpiperazine (H7) suppressed the effect of Epo and PMA, whereas a nonspecific protein kinase inhibitor, N-(2-Guanidinoethyl)-5-Isoquinolinesulfornamine (HA1004) inhibited the action of neither Epo nor PMA.	Tetradecanoylphorbol Acetate	123-126	erythropoietin	Mus musculus	265-268
24733900-7	2014	Intrabody expression did not affect the overall accumulation of pSSTAT3 induced by interleukin-6 or phorbol 12-myristate 13-acetate (PMA), the PMA-induced expression of the c-Fos gene, or the PMA-induced accumulation of pSSTAT3 specifically in mitochondria.	Tetradecanoylphorbol Acetate	143-146	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	173-178
8005230-8	1994	On the other hand, the PKC inhibitor 1-(5-isoquinolynyl-sulfonyl)-2-methylpiperazine (H7) suppressed the effect of Epo and PMA, whereas a nonspecific protein kinase inhibitor, N-(2-Guanidinoethyl)-5-Isoquinolinesulfornamine (HA1004) inhibited the action of neither Epo nor PMA.	Tetradecanoylphorbol Acetate	273-276	erythropoietin	Mus musculus	115-118
24722289-12	2014	Phorbol 12-myristate 13-acetate (PMA), which stimulates PKCs, induced p66(Shc) phosphorylation and this was inhibited by ruboxistaurin and PKCbeta2 siRNA.	Tetradecanoylphorbol Acetate	0-31	SHC adaptor protein 1	Homo sapiens	74-77
24240680-4	2014	Treatment of Caggs-Cre/FR-Hras(G12V) mice with TPA alone was sufficient to trigger papilloma development with a shorter latency and an ~10-fold greater tumor burden than DMBA/TPA-treated WT-controls.	Tetradecanoylphorbol Acetate	47-50	Harvey rat sarcoma virus oncogene	Mus musculus	26-30
24240680-5	2014	Hras(G12V) allele copy number was increased in all papillomas induced by TPA.	Tetradecanoylphorbol Acetate	73-76	Harvey rat sarcoma virus oncogene	Mus musculus	0-4
8143789-3	1994	In the present study, we have first examined the synergistic effects of cAMP and TPA on the gene expression of activin A, an important regulator of cell growth and differentiation, and next we revealed their ordered action in HT1080 cells.	Tetradecanoylphorbol Acetate	81-84	inhibin subunit beta E	Homo sapiens	111-118
24240680-6	2014	DMBA/TPA treatment of Hras(G12V) knock-in mice induced an even greater incidence of papillomas, which either harbored Hras(G12V) amplification or developed an Hras(Q61L) mutation in the second allele.	Tetradecanoylphorbol Acetate	5-8	Harvey rat sarcoma virus oncogene	Mus musculus	22-26
24240680-6	2014	DMBA/TPA treatment of Hras(G12V) knock-in mice induced an even greater incidence of papillomas, which either harbored Hras(G12V) amplification or developed an Hras(Q61L) mutation in the second allele.	Tetradecanoylphorbol Acetate	5-8	Harvey rat sarcoma virus oncogene	Mus musculus	118-122
24722289-12	2014	Phorbol 12-myristate 13-acetate (PMA), which stimulates PKCs, induced p66(Shc) phosphorylation and this was inhibited by ruboxistaurin and PKCbeta2 siRNA.	Tetradecanoylphorbol Acetate	33-36	SHC adaptor protein 1	Homo sapiens	74-77
24240680-6	2014	DMBA/TPA treatment of Hras(G12V) knock-in mice induced an even greater incidence of papillomas, which either harbored Hras(G12V) amplification or developed an Hras(Q61L) mutation in the second allele.	Tetradecanoylphorbol Acetate	5-8	Harvey rat sarcoma virus oncogene	Mus musculus	118-122
8143789-4	1994	A combined treatment of these cells with cAMP and TPA synergistically increased accumulation of the activin A mRNA.	Tetradecanoylphorbol Acetate	50-53	inhibin subunit beta E	Homo sapiens	100-107
24699135-5	2014	LR11 was not expressed in THP-1 monocytes, but it was expressed and released in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 macrophages (PMA/THP-1).	Tetradecanoylphorbol Acetate	80-111	sortilin related receptor 1	Homo sapiens	0-4
25174454-10	2014	The siRNA studies also showed that PMA-induced MMP-9 expression is NF-kappaB-dependent.	Tetradecanoylphorbol Acetate	35-38	matrix metallopeptidase 9	Homo sapiens	47-52
8143789-6	1994	In contrast, the increase in activin A mRNA levels in those cells preexposed to cAMP with subsequent treatment by TPA was limited to that caused by TPA alone, suggesting an importance of ordered stimulation.	Tetradecanoylphorbol Acetate	114-117	inhibin subunit beta E	Homo sapiens	29-36
24699135-5	2014	LR11 was not expressed in THP-1 monocytes, but it was expressed and released in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 macrophages (PMA/THP-1).	Tetradecanoylphorbol Acetate	113-116	sortilin related receptor 1	Homo sapiens	0-4
24699135-9	2014	Likewise, the PMA-stimulated release of sLR11 increased in THP-1 cells transfected with CD9-targeted shRNAs, which was negated by treatment with the metalloproteinase inhibitor GM6001.	Tetradecanoylphorbol Acetate	14-17	CD9 molecule	Homo sapiens	88-91
25260594-8	2014	Further investigation disclosed that the AP-1 activator TPA-induced MMP9 activity and the TPA-promoted migration and invasion of hepatoma cells were significantly attenuated by miR-101 but were enhanced by miR-101 inhibitor.	Tetradecanoylphorbol Acetate	56-59	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	41-45
25260594-8	2014	Further investigation disclosed that the AP-1 activator TPA-induced MMP9 activity and the TPA-promoted migration and invasion of hepatoma cells were significantly attenuated by miR-101 but were enhanced by miR-101 inhibitor.	Tetradecanoylphorbol Acetate	56-59	matrix metallopeptidase 9	Homo sapiens	68-72
8143789-6	1994	In contrast, the increase in activin A mRNA levels in those cells preexposed to cAMP with subsequent treatment by TPA was limited to that caused by TPA alone, suggesting an importance of ordered stimulation.	Tetradecanoylphorbol Acetate	148-151	inhibin subunit beta E	Homo sapiens	29-36
8143789-9	1994	These results demonstrated that transient stimulation of HT1080 cells by TPA with subsequent exposure to cAMP is sufficient for the synergistic induction of the activin A gene expression and suggested that the combinatorial action of TPA followed by cAMP stimulation plays an important role in regulating activin synthesis in these cells.	Tetradecanoylphorbol Acetate	73-76	inhibin subunit beta E	Homo sapiens	161-168
25041880-7	2014	At 3 months, 58 patients (64.4% TPA) obtained a BCR-ABL transcripts level &lt;10%.	Tetradecanoylphorbol Acetate	32-35	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	48-55
8143789-9	1994	These results demonstrated that transient stimulation of HT1080 cells by TPA with subsequent exposure to cAMP is sufficient for the synergistic induction of the activin A gene expression and suggested that the combinatorial action of TPA followed by cAMP stimulation plays an important role in regulating activin synthesis in these cells.	Tetradecanoylphorbol Acetate	73-76	inhibin subunit beta E	Homo sapiens	305-312
8144923-6	1994	dbcAMP inhibited the TPA plus ionomycin-induced transcription of IL-2 and IL-2R genes in EL4 cells, suggesting interference with biochemic events downstream to PI hydrolysis and upstream to transcription of early activation genes.	Tetradecanoylphorbol Acetate	21-24	interleukin 2	Mus musculus	65-69
24637716-5	2014	Conversely, THAP11 overexpression accelerated the megakaryocytic differentiation induced by phorbol myristate acetate (PMA) with increased percentage of CD41+ cells, increased numbers of 4N cells, and elevated CD61 mRNA levels, and THAP11 knockdown attenuated the megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	92-117	integrin subunit alpha 2b	Homo sapiens	153-157
24322293-10	2014	Furthermore, intracellular cytokine staining revealed that expression of IL-4 and IL-17 were significantly enhanced in both the NK and NKT cells of infected mice after phorbol 12-myristate 13-acetate (PMA) and ionomycin stimulation (P &lt; 0.05).	Tetradecanoylphorbol Acetate	168-199	interleukin 17A	Mus musculus	82-87
24322293-10	2014	Furthermore, intracellular cytokine staining revealed that expression of IL-4 and IL-17 were significantly enhanced in both the NK and NKT cells of infected mice after phorbol 12-myristate 13-acetate (PMA) and ionomycin stimulation (P &lt; 0.05).	Tetradecanoylphorbol Acetate	201-204	interleukin 17A	Mus musculus	82-87
8144923-9	1994	Furthermore, the TPA plus ionomycin-induced transcription program of members of the jun and fos family of genes was altered by dbcAMP, suggesting that inhibition of T cell proliferation by dbcAMP is a consequence of intervention in transcriptional regulation by TRE-binding proteins.	Tetradecanoylphorbol Acetate	17-20	FBJ osteosarcoma oncogene	Mus musculus	92-95
8183247-5	1994	Expression in several cell lines in culture reveals that rapid TRH-R desensitization by TRH and phorbol 12-myristate 13-acetate is cell type specific.	Tetradecanoylphorbol Acetate	96-127	thyrotropin releasing hormone receptor	Homo sapiens	63-68
8142369-4	1994	Addition of the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol 13-acetate (TPA), or the Ca2+ ionophore, ionomycin, mimicked the profile of GnRH-induced alpha and LH beta mRNA elevation.	Tetradecanoylphorbol Acetate	88-91	gonadotropin releasing hormone 1	Rattus norvegicus	152-156
24753817-0	2014	12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin 8 Phosphorylation and Reorganization via Expression of Transglutaminase-2.	Tetradecanoylphorbol Acetate	0-36	keratin 8	Homo sapiens	45-54
24753817-5	2014	Therefore, we examined the underlying mechanism and effect of TPA on K8 phosphorylation and reorganization.	Tetradecanoylphorbol Acetate	62-65	keratin 8	Homo sapiens	69-71
8142369-5	1994	The two phases of FSH beta mRNA elevation induced by GnRH could be mimicked by TPA, while the decrease at 6 h was mimicked by ionomycin.	Tetradecanoylphorbol Acetate	79-82	gonadotropin releasing hormone 1	Rattus norvegicus	53-57
24753817-6	2014	TPA induced phosphorylation and reorganization of K8 and transglutaminase-2 (Tgase-2) expression in a time- and dose-dependent manner in PANC-1 cells.	Tetradecanoylphorbol Acetate	0-3	keratin 8	Homo sapiens	50-52
24753817-8	2014	We next investigated, using cystamine (CTM), Tgase inhibitor, and Tgase-2 gene silencing, Tgase-2"s possible involvement in TPA-induced K8 phosphorylation and reorganization.	Tetradecanoylphorbol Acetate	124-127	keratin 8	Homo sapiens	136-138
8141770-3	1994	Activation of superoxide production by phorbol 12-myristate 13-acetate or formylmethionyl-leucyl-phenylalanine in whole cells, and by SDS in the cell-free assay, led to the dissociation of some of the p21rac2 from rhoGDI and its movement to the plasma membrane together with p47phox and p67phox.	Tetradecanoylphorbol Acetate	39-70	Rho GDP dissociation inhibitor alpha	Homo sapiens	214-220
7510248-4	1994	In cells pretreated with 12-O-tetradecanoylphorbol 13-acetate, induction of c-fos by hypergravity was almost completely abolished, whereas that of egr-1 was not affected.	Tetradecanoylphorbol Acetate	25-61	FBJ osteosarcoma oncogene	Mus musculus	76-81
24190483-6	2014	Osteosarcoma and rhabdomyosarcoma showed bands corresponding to MMP-2 and -9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	123-154	matrix metallopeptidase 9	Homo sapiens	112-117
24190483-6	2014	Osteosarcoma and rhabdomyosarcoma showed bands corresponding to MMP-2 and -9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	156-159	matrix metallopeptidase 9	Homo sapiens	112-117
7510248-4	1994	In cells pretreated with 12-O-tetradecanoylphorbol 13-acetate, induction of c-fos by hypergravity was almost completely abolished, whereas that of egr-1 was not affected.	Tetradecanoylphorbol Acetate	25-61	early growth response 1	Mus musculus	147-152
23884247-6	2014	From various stimuli tested, 12-O-tetradecanoylphorbol-13-acetate and tunicamycin affected SKI-1 expression.	Tetradecanoylphorbol Acetate	29-65	membrane bound transcription factor peptidase, site 1	Homo sapiens	91-96
8109973-1	1994	The capacity of human neutrophils to bind PAF was rapidly diminished upon cell stimulation with both physiological agonists (N-formylmethionylleucylphenylalanine (FMLP), leukotriene B4 (LTB4)) and pharmacologic agonists (phorbol 12-myristate 13-acetate (PMA), A23187).	Tetradecanoylphorbol Acetate	221-252	PCNA clamp associated factor	Homo sapiens	42-45
24085323-5	2013	Fibrosarcoma, chondrosarcoma, liposarcoma and synovial sarcoma showed bands corresponding to MMP-2 and MMP-9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	188-191	matrix metallopeptidase 9	Homo sapiens	144-149
8109973-1	1994	The capacity of human neutrophils to bind PAF was rapidly diminished upon cell stimulation with both physiological agonists (N-formylmethionylleucylphenylalanine (FMLP), leukotriene B4 (LTB4)) and pharmacologic agonists (phorbol 12-myristate 13-acetate (PMA), A23187).	Tetradecanoylphorbol Acetate	254-257	PCNA clamp associated factor	Homo sapiens	42-45
8109973-6	1994	PMA-induced PAF receptor downregulation was staurosporine-sensitive while PAF receptor downregulation by A23187, FMLP, or LTB4 was staurosporine-resistant.	Tetradecanoylphorbol Acetate	0-3	PCNA clamp associated factor	Homo sapiens	12-15
7905499-6	1994	Stimulation of transfected T cells with the mitogen Con A, anti-CD3 Ab, or PMA plus ionomycin activated the IL2ZH construct in Th1 but not Th2 cells.	Tetradecanoylphorbol Acetate	75-78	heart and neural crest derivatives expressed 2	Mus musculus	139-142
8289830-4	1994	In vitro translated purified Vav activated by phorbol myristate acetate (PMA) or phosphorylation with recombinant p56lck displayed GEF activity against Ras but not against recombinant RacI, RacII, Ral, or RhoA proteins.	Tetradecanoylphorbol Acetate	46-71	vav 1 oncogene	Mus musculus	29-32
23470260-7	2013	Stimulation with the ADAM17 agonist chemokine phorbol myristate acetate increased migration and invasion of GSCs, which was counteracted by ADAM17 knockdown.	Tetradecanoylphorbol Acetate	46-71	ADAM metallopeptidase domain 17	Homo sapiens	21-27
8289830-4	1994	In vitro translated purified Vav activated by phorbol myristate acetate (PMA) or phosphorylation with recombinant p56lck displayed GEF activity against Ras but not against recombinant RacI, RacII, Ral, or RhoA proteins.	Tetradecanoylphorbol Acetate	46-71	rho/rac guanine nucleotide exchange factor (GEF) 2	Mus musculus	131-134
23470260-7	2013	Stimulation with the ADAM17 agonist chemokine phorbol myristate acetate increased migration and invasion of GSCs, which was counteracted by ADAM17 knockdown.	Tetradecanoylphorbol Acetate	46-71	ADAM metallopeptidase domain 17	Homo sapiens	140-146
8289830-4	1994	In vitro translated purified Vav activated by phorbol myristate acetate (PMA) or phosphorylation with recombinant p56lck displayed GEF activity against Ras but not against recombinant RacI, RacII, Ral, or RhoA proteins.	Tetradecanoylphorbol Acetate	73-76	vav 1 oncogene	Mus musculus	29-32
8289830-4	1994	In vitro translated purified Vav activated by phorbol myristate acetate (PMA) or phosphorylation with recombinant p56lck displayed GEF activity against Ras but not against recombinant RacI, RacII, Ral, or RhoA proteins.	Tetradecanoylphorbol Acetate	73-76	rho/rac guanine nucleotide exchange factor (GEF) 2	Mus musculus	131-134
8288885-2	1994	In contrast to mature T cells or the Jurkat cell line, PER-117 cells require interleukin-1 (IL-1) for optimal IL-2 secretion, in addition to calcium ionophore and phorbol 12-myristate 12-acetate (PMA).	Tetradecanoylphorbol Acetate	196-199	interleukin 1 alpha	Homo sapiens	92-96
23933110-0	2013	Luteolin 8-C-beta-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-kappaB signaling in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	66-69	matrix metallopeptidase 9	Homo sapiens	78-83
24152909-5	2013	The expression of MMP-9 and cell invasion increased after TPA treatment, whereas TPA-induced MMP-9 expression and cell invasion were decreased by BVT948 pretreatment.	Tetradecanoylphorbol Acetate	58-61	matrix metallopeptidase 9	Homo sapiens	18-23
24152909-5	2013	The expression of MMP-9 and cell invasion increased after TPA treatment, whereas TPA-induced MMP-9 expression and cell invasion were decreased by BVT948 pretreatment.	Tetradecanoylphorbol Acetate	81-84	matrix metallopeptidase 9	Homo sapiens	93-98
23937324-4	2013	Contrary to PKCalpha and zeta, expression of PKCdelta in isc1Delta cells exhibited a similar phenotype to that observed with wild-type yeast cells expressing PKCdelta treated with a PKC activator, as phorbol 12-myristate 13-acetate (PMA), specifically a growth inhibition associated with a G2/M cell cycle arrest.	Tetradecanoylphorbol Acetate	200-231	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	57-61
23647458-6	2013	Finally, DHA uptake by GLUT1 in choroid plexus cells was assessed in the presence of phorbol-12-myristate-13-acetate (PMA)-activated human neutrophils.	Tetradecanoylphorbol Acetate	85-116	solute carrier family 2 member 1	Homo sapiens	23-28
23647458-6	2013	Finally, DHA uptake by GLUT1 in choroid plexus cells was assessed in the presence of phorbol-12-myristate-13-acetate (PMA)-activated human neutrophils.	Tetradecanoylphorbol Acetate	118-121	solute carrier family 2 member 1	Homo sapiens	23-28
24053256-0	2013	Selaginella tamariscina extract suppresses TPA-induced invasion and metastasis through inhibition of MMP-9 in human nasopharyngeal carcinoma HONE-1 cells.	Tetradecanoylphorbol Acetate	43-46	matrix metallopeptidase 9	Homo sapiens	101-106
24053256-7	2013	Treatment of STE on TPA-induced HONE-1 cells inhibited MMP-9 expression and ERK1/2 phosphorylation without affecting JNK and p38 phosphorylation.	Tetradecanoylphorbol Acetate	20-23	matrix metallopeptidase 9	Homo sapiens	55-60
24212062-5	2013	FACS results indicated that Th17 cell was the main source of IL-17 in the infected pulmonary lymphocytes after phorbol-12-myristate-13-acetate (PMA) and Ionomycin stimulation.	Tetradecanoylphorbol Acetate	111-142	interleukin 17A	Mus musculus	61-66
24212062-5	2013	FACS results indicated that Th17 cell was the main source of IL-17 in the infected pulmonary lymphocytes after phorbol-12-myristate-13-acetate (PMA) and Ionomycin stimulation.	Tetradecanoylphorbol Acetate	144-147	interleukin 17A	Mus musculus	61-66
24084455-5	2013	Phorbol 12-myristate 13-acetate (PMA), 100 ng/ml was added to cells to induce MMP-9 secretion.	Tetradecanoylphorbol Acetate	0-31	matrix metallopeptidase 9	Homo sapiens	78-83
24084455-5	2013	Phorbol 12-myristate 13-acetate (PMA), 100 ng/ml was added to cells to induce MMP-9 secretion.	Tetradecanoylphorbol Acetate	33-36	matrix metallopeptidase 9	Homo sapiens	78-83
24084455-8	2013	Zymography did not demonstrate MMP-2 or MMP-9 secretion in normal cells; however, PMA strongly induced MMP-9, which was inhibited by NM in a dose-dependent manner.	Tetradecanoylphorbol Acetate	82-85	matrix metallopeptidase 9	Homo sapiens	103-108
23977008-9	2013	In HL-60 and THP1 cells, KLF6 mRNA and protein levels are up-regulated with a concordant reduction of PTTG1 expression upon treatment with PMA.	Tetradecanoylphorbol Acetate	139-142	Kruppel like factor 6	Homo sapiens	25-29
23977008-11	2013	The protein kinase C (PKC) inhibitor and the MAPK/ERK kinase (MEK) inhibitor significantly blocked the potentiation of PMA-mediated KLF6 induction and the down-regulation of PTTG1, indicating that PTTG1 is suppressed via the activation of PKC/ERK/KLF6 pathway.	Tetradecanoylphorbol Acetate	119-122	Kruppel like factor 6	Homo sapiens	132-136
23977008-11	2013	The protein kinase C (PKC) inhibitor and the MAPK/ERK kinase (MEK) inhibitor significantly blocked the potentiation of PMA-mediated KLF6 induction and the down-regulation of PTTG1, indicating that PTTG1 is suppressed via the activation of PKC/ERK/KLF6 pathway.	Tetradecanoylphorbol Acetate	119-122	Kruppel like factor 6	Homo sapiens	247-251
23615401-0	2013	Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	48-51	matrix metallopeptidase 9	Homo sapiens	60-86
23615401-4	2013	In this study, we investigated the effect of AP on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and invasion in MCF-7 breast cancer cells and the possible mechanisms involved.	Tetradecanoylphorbol Acetate	51-87	matrix metallopeptidase 9	Homo sapiens	102-107
23615401-4	2013	In this study, we investigated the effect of AP on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and invasion in MCF-7 breast cancer cells and the possible mechanisms involved.	Tetradecanoylphorbol Acetate	89-92	matrix metallopeptidase 9	Homo sapiens	102-107
23615401-5	2013	The results showed that AP dose-dependently inhibited TPA-induced MMP-9 protein expression, enzyme activity, migration and invasion.	Tetradecanoylphorbol Acetate	54-57	matrix metallopeptidase 9	Homo sapiens	66-71
23615401-8	2013	HO-1 end products, such as carbon monoxide, free iron and bilirubin, suppressed the TPA-induced MMP-9 mRNA and protein expression, enzyme activity, migration and invasion in MCF-7 cells.	Tetradecanoylphorbol Acetate	84-87	matrix metallopeptidase 9	Homo sapiens	96-101
23615401-10	2013	In conclusion, these results suggest that AP inhibits TPA-induced cell migration and invasion by reducing MMP-9 activation, which is mediated mainly by inhibition of the ERK1/2 and phosphatidylinositol 3-kinase/Akt signaling pathways and subsequent AP-1 and NF-kappaB transactivation.	Tetradecanoylphorbol Acetate	54-57	matrix metallopeptidase 9	Homo sapiens	106-111
23615401-11	2013	Additionally, induction of HO-1 expression is at least partially involved in the inhibition of TPA-induced MMP-9 activation and cell migration in MCF-7 cells by AP.	Tetradecanoylphorbol Acetate	95-98	matrix metallopeptidase 9	Homo sapiens	107-112
23584792-10	2013	Forskolin (FSK)/phorbol 12-myristate 13-acetate (PMA), to mimic PGE(2), resulted in a further significant increase in PII activity with all CRTCs, with CRTC2 and CRTC3 having greater effects.	Tetradecanoylphorbol Acetate	16-47	CREB regulated transcription coactivator 2	Homo sapiens	152-157
23584792-10	2013	Forskolin (FSK)/phorbol 12-myristate 13-acetate (PMA), to mimic PGE(2), resulted in a further significant increase in PII activity with all CRTCs, with CRTC2 and CRTC3 having greater effects.	Tetradecanoylphorbol Acetate	49-52	CREB regulated transcription coactivator 2	Homo sapiens	152-157
23584792-12	2013	Moreover, gene silencing of CRTC2 and CRTC3 significantly reduced the FSK/PMA-mediated stimulation of aromatase activity.	Tetradecanoylphorbol Acetate	74-77	CREB regulated transcription coactivator 2	Homo sapiens	28-33
23551262-5	2013	Expression and release of IL-17 was significantly higher in hepatic lymphocytes from infected mice compared with control mice in response to both non-specific stimulation with anti-CD3 monoclonal antibody plus/anti-CD28 monoclonal antibody and PMA plus ionomycin.	Tetradecanoylphorbol Acetate	244-247	interleukin 17A	Mus musculus	26-31
23664529-8	2013	By BANF1 knockdown in TPA-stimulated HSC-1 cells, the mRNA levels of S100A9 were significantly elevated compared with those of control HSC-1 cells treated with siRNA to CD4.	Tetradecanoylphorbol Acetate	22-25	S100 calcium binding protein A9	Homo sapiens	69-75
23775122-2	2013	PKC activation by phorbol ester (phorbol myristate acetate [PMA]) reduced insulin-induced p-Tyr-IRS2 by 46% +- 13% and, similarly, phosphorylation of Akt/eNOS.	Tetradecanoylphorbol Acetate	33-58	protein kinase C, beta	Rattus norvegicus	0-3
23775122-2	2013	PKC activation by phorbol ester (phorbol myristate acetate [PMA]) reduced insulin-induced p-Tyr-IRS2 by 46% +- 13% and, similarly, phosphorylation of Akt/eNOS.	Tetradecanoylphorbol Acetate	33-58	insulin receptor substrate 2	Cricetulus griseus	90-100
23775122-2	2013	PKC activation by phorbol ester (phorbol myristate acetate [PMA]) reduced insulin-induced p-Tyr-IRS2 by 46% +- 13% and, similarly, phosphorylation of Akt/eNOS.	Tetradecanoylphorbol Acetate	33-58	nitric oxide synthase 3	Rattus norvegicus	154-158
23775122-2	2013	PKC activation by phorbol ester (phorbol myristate acetate [PMA]) reduced insulin-induced p-Tyr-IRS2 by 46% +- 13% and, similarly, phosphorylation of Akt/eNOS.	Tetradecanoylphorbol Acetate	60-63	protein kinase C, beta	Rattus norvegicus	0-3
23775122-2	2013	PKC activation by phorbol ester (phorbol myristate acetate [PMA]) reduced insulin-induced p-Tyr-IRS2 by 46% +- 13% and, similarly, phosphorylation of Akt/eNOS.	Tetradecanoylphorbol Acetate	60-63	insulin receptor substrate 2	Cricetulus griseus	90-100
23775122-2	2013	PKC activation by phorbol ester (phorbol myristate acetate [PMA]) reduced insulin-induced p-Tyr-IRS2 by 46% +- 13% and, similarly, phosphorylation of Akt/eNOS.	Tetradecanoylphorbol Acetate	60-63	nitric oxide synthase 3	Rattus norvegicus	154-158
23775122-3	2013	Site-specific mutational analysis showed that PMA increased serine phosphorylation at three sites on IRS2 (positions 303, 343, and 675), which affected insulin-induced tyrosine phosphorylation of IRS2 at positions 653, 671, and 911 (p-Tyr-IRS2) and p-Akt/eNOS.	Tetradecanoylphorbol Acetate	46-49	nitric oxide synthase 3	Rattus norvegicus	255-259
23866919-6	2013	Such abilities as interaction of LRP1 with NMDA receptor subunits or its important role in tPa-mediated NMDA receptor signaling were already demonstrated.	Tetradecanoylphorbol Acetate	91-94	low density lipoprotein receptor-related protein 1	Mus musculus	33-37
23230284-8	2013	Interestingly, in untagged fibulin-3 studies, one compound, phorbol 12-myristate 13-acetate, reduced R345W fibulin-3 secretion while minimally enhancing WT fibulin-3 secretion, the desired activity and selectivity we sought for ML.	Tetradecanoylphorbol Acetate	60-91	EGF containing fibulin extracellular matrix protein 1	Homo sapiens	107-116
23230284-8	2013	Interestingly, in untagged fibulin-3 studies, one compound, phorbol 12-myristate 13-acetate, reduced R345W fibulin-3 secretion while minimally enhancing WT fibulin-3 secretion, the desired activity and selectivity we sought for ML.	Tetradecanoylphorbol Acetate	60-91	EGF containing fibulin extracellular matrix protein 1	Homo sapiens	107-116
23702712-10	2013	KB-R7785 and ADAM17 depletion significantly blocked TNF-alpha shedding by TPA.	Tetradecanoylphorbol Acetate	74-77	ADAM metallopeptidase domain 17	Homo sapiens	13-19
24276261-3	2013	In this brief report, we investigate the potential involvement of CaV2 VDCC subtypes in functional effects of the phorbol ester, phorbol 12-myristate 13-acetate (PMA) on nociceptive transmission in the spinal cord.	Tetradecanoylphorbol Acetate	162-165	caveolin 2	Mus musculus	66-70
23635876-7	2013	Glomerular mRNA expression of KLF2 and KLF4 correlated with that of tPA and inversely with that of PAI-1 in rTx-TMA.	Tetradecanoylphorbol Acetate	68-71	Kruppel like factor 4	Homo sapiens	39-43
23589174-8	2013	SBI-0089410 inhibited the 12-O-tetradecanoylphorbol-l3-acetate (TPA)-induced membrane translocation of protein kinase C (PKC) isoforms, whereas both compounds decreased ATF2 phosphorylation by PKCepsilon and ATF2 transcriptional activity.	Tetradecanoylphorbol Acetate	64-67	activating transcription factor 2	Homo sapiens	208-212
23675462-5	2013	Here, we demonstrate that both MSK1 and MSK2, regulate the phorbol ester 12-O-tetradecanoylphorbol-13-acetate induced expression of the breast cancer marker gene, trefoil factor 1 (TFF1), by phosphorylating H3S10 at its 5" regulatory regions.	Tetradecanoylphorbol Acetate	73-109	ribosomal protein S6 kinase A4	Homo sapiens	40-44
25010822-7	2014	RESULTS: BF1 inhibited the hypersensitivity and paw edema induced by intraplantar injection of carrageenan, BK, and PGE2 (P &lt; 0.001), and it was effective in reducing the hypersensitivity evoked by complete Freund adjuvant or epinephrine (P &lt; 0.001) but not by lipopolysaccharide (P = 0.2570).	Tetradecanoylphorbol Acetate	122-127	forkhead box G1	Mus musculus	9-12
25010822-7	2014	RESULTS: BF1 inhibited the hypersensitivity and paw edema induced by intraplantar injection of carrageenan, BK, and PGE2 (P &lt; 0.001), and it was effective in reducing the hypersensitivity evoked by complete Freund adjuvant or epinephrine (P &lt; 0.001) but not by lipopolysaccharide (P = 0.2570).	Tetradecanoylphorbol Acetate	242-247	forkhead box G1	Mus musculus	9-12
25010822-8	2014	BF1 inhibited the licking behavior induced by phorbol myristate acetate (P &lt; 0.001), suggesting involvement of the PKC pathway.	Tetradecanoylphorbol Acetate	46-71	forkhead box G1	Mus musculus	0-3
25027711-6	2014	TPA-induced phosphorylation of Akt, S6 kinase (S6K), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) in mouse skin was lower in the curcumin group than in the control group.	Tetradecanoylphorbol Acetate	0-3	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	36-45
25027711-6	2014	TPA-induced phosphorylation of Akt, S6 kinase (S6K), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) in mouse skin was lower in the curcumin group than in the control group.	Tetradecanoylphorbol Acetate	0-3	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	47-50
25178676-5	2014	We demonstrated that IL-32alpha interacts with protein kinase C (PKC)delta and PKCe in a phorbol 12-myristate 13-acetate (PMA) dependent way, and that PKCe regulates the interaction of IL-32alpha with PLZF.	Tetradecanoylphorbol Acetate	122-125	zinc finger and BTB domain containing 16	Homo sapiens	201-205
25245533-3	2014	In this study, we showed that PMA induces an interaction between IL-32alpha, PKCepsilon, and BCL6, forming a trimer.	Tetradecanoylphorbol Acetate	30-33	BCL6 transcription repressor	Homo sapiens	93-97
25245533-7	2014	Further, the pan-PKC inhibitor and PKCepsilon inhibitor disrupted PMA-induced interaction between IL-32alpha and BCL6.	Tetradecanoylphorbol Acetate	66-69	BCL6 transcription repressor	Homo sapiens	113-117
25245533-9	2014	PMA induces post-translational modification of BCL6 by conjugation to SUMO-2, while IL-32alpha inhibits.	Tetradecanoylphorbol Acetate	0-3	BCL6 transcription repressor	Homo sapiens	47-51
25245533-9	2014	PMA induces post-translational modification of BCL6 by conjugation to SUMO-2, while IL-32alpha inhibits.	Tetradecanoylphorbol Acetate	0-3	small ubiquitin like modifier 2	Homo sapiens	70-76
25245533-10	2014	PKCepsilon inhibition eliminated PMA-induced SUMOylation of BCL6.	Tetradecanoylphorbol Acetate	33-36	BCL6 transcription repressor	Homo sapiens	60-64
25244493-8	2014	Inhibition of ERK activation blocks phorbol myristate acetate-induced MMP-9 activity and VEGF-A secretion in vitro.	Tetradecanoylphorbol Acetate	36-61	matrix metallopeptidase 9	Homo sapiens	70-75
23288142-0	2013	Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	108-144	matrix metallopeptidase 9	Homo sapiens	14-40
23288142-4	2013	We found that TPA (100 ng/ml) induced MMP-9 enzyme activity both dose- and time-dependently, and 200 muM DHA and LA significantly inhibited MMP-9 mRNA and protein expression, enzyme activity, cell migration, and invasion.	Tetradecanoylphorbol Acetate	14-17	matrix metallopeptidase 9	Homo sapiens	38-43
23288142-5	2013	Treatment with PD98059 (10 muM), wortmannin (10 muM), and GF109203X (0.5 muM) decreased TPA-induced MMP-9 protein expression and enzyme activity.	Tetradecanoylphorbol Acetate	88-91	matrix metallopeptidase 9	Homo sapiens	100-105
8308281-3	1994	Using the assay, LIF/HILDA was measurable in supernatants after in vitro whole blood stimulation with phytohemagglutinin (PHA), OKT3, and phorbol myristate acetate (PMA) but not with lipopolysaccharide (LPS) or Ca ionophore.	Tetradecanoylphorbol Acetate	138-163	LIF interleukin 6 family cytokine	Homo sapiens	17-20
8308281-3	1994	Using the assay, LIF/HILDA was measurable in supernatants after in vitro whole blood stimulation with phytohemagglutinin (PHA), OKT3, and phorbol myristate acetate (PMA) but not with lipopolysaccharide (LPS) or Ca ionophore.	Tetradecanoylphorbol Acetate	138-163	LIF interleukin 6 family cytokine	Homo sapiens	21-26
8308281-3	1994	Using the assay, LIF/HILDA was measurable in supernatants after in vitro whole blood stimulation with phytohemagglutinin (PHA), OKT3, and phorbol myristate acetate (PMA) but not with lipopolysaccharide (LPS) or Ca ionophore.	Tetradecanoylphorbol Acetate	165-168	LIF interleukin 6 family cytokine	Homo sapiens	17-20
8308281-3	1994	Using the assay, LIF/HILDA was measurable in supernatants after in vitro whole blood stimulation with phytohemagglutinin (PHA), OKT3, and phorbol myristate acetate (PMA) but not with lipopolysaccharide (LPS) or Ca ionophore.	Tetradecanoylphorbol Acetate	165-168	LIF interleukin 6 family cytokine	Homo sapiens	21-26
8282054-7	1994	TPA at 1 and 10 nM inhibited GM-CSF binding.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 2	Homo sapiens	29-35
23297317-3	2013	In the present study, to investigate the effects of radiation on phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic differentiation of K562 cells, the cellular processes responsible for the expression of CD41 antigen (GPIIb/IIIa), which is reported to be expressed early in megakaryocyte maturation, were analyzed.	Tetradecanoylphorbol Acetate	98-101	integrin subunit alpha 2b	Homo sapiens	214-218
23297317-3	2013	In the present study, to investigate the effects of radiation on phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic differentiation of K562 cells, the cellular processes responsible for the expression of CD41 antigen (GPIIb/IIIa), which is reported to be expressed early in megakaryocyte maturation, were analyzed.	Tetradecanoylphorbol Acetate	98-101	integrin subunit alpha 2b	Homo sapiens	228-233
8282054-8	1994	Inhibition of GM-CSF binding by a combination of ET-18-OCH3 (10 microM) and TPA (1 or 10 nM) was less than additive, and ET-18-OCH3 partially inhibited TPA-induced protein kinase C (PKC) depletion in the cytosol and translocation to the particulate fractions.	Tetradecanoylphorbol Acetate	76-79	colony stimulating factor 2	Homo sapiens	14-20
7514078-5	1994	Stimulation with phorbol 12-myristate 13-acetate (PMA), however, gave rise to large, plastic adherent cells which also showed strong homotypic adhesion, expressed CD62L at minimal levels and CD11c at comparably highest levels and altogether mimicked the large cell variant of EF B cells.	Tetradecanoylphorbol Acetate	17-48	selectin L	Homo sapiens	163-168
23416458-5	2013	Higher levels of IL-17 and IFN-gamma were produced by stimulation with PMA/Ionomycin compared to anti-CD3/anti-CD28.	Tetradecanoylphorbol Acetate	71-74	interleukin 17A	Homo sapiens	17-22
23416458-8	2013	Furthermore the dose response curve for PMA/Ionomycin differed for IL-10 compared to IL-17 and IFN-gamma as it was biphasic with no IL-10 production at higher PMA/Ionomycin concentrations.	Tetradecanoylphorbol Acetate	40-43	interleukin 10	Homo sapiens	67-72
7514078-5	1994	Stimulation with phorbol 12-myristate 13-acetate (PMA), however, gave rise to large, plastic adherent cells which also showed strong homotypic adhesion, expressed CD62L at minimal levels and CD11c at comparably highest levels and altogether mimicked the large cell variant of EF B cells.	Tetradecanoylphorbol Acetate	50-53	selectin L	Homo sapiens	163-168
23416458-8	2013	Furthermore the dose response curve for PMA/Ionomycin differed for IL-10 compared to IL-17 and IFN-gamma as it was biphasic with no IL-10 production at higher PMA/Ionomycin concentrations.	Tetradecanoylphorbol Acetate	40-43	interleukin 17A	Homo sapiens	85-90
23416458-8	2013	Furthermore the dose response curve for PMA/Ionomycin differed for IL-10 compared to IL-17 and IFN-gamma as it was biphasic with no IL-10 production at higher PMA/Ionomycin concentrations.	Tetradecanoylphorbol Acetate	159-162	interleukin 10	Homo sapiens	67-72
8262983-5	1993	Furthermore, normal and active Fyn stimulated transcription from the IL-2 gene promoter when transfected cells were stimulated by concanavalin A plus 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	150-186	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	31-34
23377348-4	2013	The results indicate that HSP70 interaction with MARCKS is enhanced after exposure of the cells to the protein kinase C activator/mucin secretagogue, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	150-181	heat shock protein family A (Hsp70) member 4	Homo sapiens	26-31
23377348-4	2013	The results indicate that HSP70 interaction with MARCKS is enhanced after exposure of the cells to the protein kinase C activator/mucin secretagogue, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	183-186	heat shock protein family A (Hsp70) member 4	Homo sapiens	26-31
8262984-2	1993	Triggering of T cells with anti-CD3 or with phorbol 12-myristate 13-acetate (PMA) results in the appearance of slower migrating forms (shift) of p56lck.	Tetradecanoylphorbol Acetate	44-75	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	145-151
23377348-5	2013	Pretreatment of NHBEs with MAL3-101 attenuated in a concentration-dependent manner PMA-stimulated mucin secretion and interactions among HSP70, MARCKS, and CSP.	Tetradecanoylphorbol Acetate	83-86	heat shock protein family A (Hsp70) member 4	Homo sapiens	137-142
8262984-2	1993	Triggering of T cells with anti-CD3 or with phorbol 12-myristate 13-acetate (PMA) results in the appearance of slower migrating forms (shift) of p56lck.	Tetradecanoylphorbol Acetate	77-80	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	145-151
23353996-4	2013	To verify the regulatory mechanism of TPA-induced             MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126,             and TPA-induced MMP-9 expression was significantly decreased.	Tetradecanoylphorbol Acetate	162-165	matrix metallopeptidase 9	Homo sapiens	174-179
8280066-4	1993	Both inhibitors prolonged the lifetime of PKC in PMA-treated cells, and leupeptin was shown to block the PMA-stimulated appearance of PKM in the cytosol.	Tetradecanoylphorbol Acetate	105-108	pyruvate kinase M1/2	Homo sapiens	134-137
23353996-5	2013	We also found that             TPA-induced cell migration and MMP-9 expression was significantly decreased by             silibinin.	Tetradecanoylphorbol Acetate	31-34	matrix metallopeptidase 9	Homo sapiens	62-67
8250033-8	1993	A 45-minute incubation of cells with phorbol 12-myristate 13-acetate caused a concentration-dependent decrease in EGF binding that was prevented by a 40-hour, 2 mumol/L pre-exposure to phorbol 12-myristate 13-acetate; 10(-8) mol/L EGF also caused a downregulation of the EGF receptor that was not prevented by phorbol 12-myristate 13-acetate or retinoic acid.	Tetradecanoylphorbol Acetate	37-68	epidermal growth factor	Sus scrofa	114-117
23512660-3	2013	Reduced exposure to TPA-induced chronic inflammation causes a dramatic reduction in classical papillomas and squamous cell carcinomas (SCCs), but the mice still develop highly invasive carcinomas with EMT properties, reduced levels of Hras and Egfr signaling, and frequent Ink4/Arf deletions.	Tetradecanoylphorbol Acetate	20-23	Harvey rat sarcoma virus oncogene	Mus musculus	235-239
8250033-8	1993	A 45-minute incubation of cells with phorbol 12-myristate 13-acetate caused a concentration-dependent decrease in EGF binding that was prevented by a 40-hour, 2 mumol/L pre-exposure to phorbol 12-myristate 13-acetate; 10(-8) mol/L EGF also caused a downregulation of the EGF receptor that was not prevented by phorbol 12-myristate 13-acetate or retinoic acid.	Tetradecanoylphorbol Acetate	37-68	epidermal growth factor	Sus scrofa	231-234
8250033-8	1993	A 45-minute incubation of cells with phorbol 12-myristate 13-acetate caused a concentration-dependent decrease in EGF binding that was prevented by a 40-hour, 2 mumol/L pre-exposure to phorbol 12-myristate 13-acetate; 10(-8) mol/L EGF also caused a downregulation of the EGF receptor that was not prevented by phorbol 12-myristate 13-acetate or retinoic acid.	Tetradecanoylphorbol Acetate	37-68	epidermal growth factor	Sus scrofa	231-234
8250033-8	1993	A 45-minute incubation of cells with phorbol 12-myristate 13-acetate caused a concentration-dependent decrease in EGF binding that was prevented by a 40-hour, 2 mumol/L pre-exposure to phorbol 12-myristate 13-acetate; 10(-8) mol/L EGF also caused a downregulation of the EGF receptor that was not prevented by phorbol 12-myristate 13-acetate or retinoic acid.	Tetradecanoylphorbol Acetate	185-216	epidermal growth factor	Sus scrofa	114-117
8250033-8	1993	A 45-minute incubation of cells with phorbol 12-myristate 13-acetate caused a concentration-dependent decrease in EGF binding that was prevented by a 40-hour, 2 mumol/L pre-exposure to phorbol 12-myristate 13-acetate; 10(-8) mol/L EGF also caused a downregulation of the EGF receptor that was not prevented by phorbol 12-myristate 13-acetate or retinoic acid.	Tetradecanoylphorbol Acetate	185-216	epidermal growth factor	Sus scrofa	231-234
8250033-8	1993	A 45-minute incubation of cells with phorbol 12-myristate 13-acetate caused a concentration-dependent decrease in EGF binding that was prevented by a 40-hour, 2 mumol/L pre-exposure to phorbol 12-myristate 13-acetate; 10(-8) mol/L EGF also caused a downregulation of the EGF receptor that was not prevented by phorbol 12-myristate 13-acetate or retinoic acid.	Tetradecanoylphorbol Acetate	185-216	epidermal growth factor	Sus scrofa	231-234
8250033-8	1993	A 45-minute incubation of cells with phorbol 12-myristate 13-acetate caused a concentration-dependent decrease in EGF binding that was prevented by a 40-hour, 2 mumol/L pre-exposure to phorbol 12-myristate 13-acetate; 10(-8) mol/L EGF also caused a downregulation of the EGF receptor that was not prevented by phorbol 12-myristate 13-acetate or retinoic acid.	Tetradecanoylphorbol Acetate	185-216	epidermal growth factor	Sus scrofa	114-117
22490516-5	2013	Pancreatic acini were coincubated in vitro from wild-type and cathepsin-B-deficient animals with phorbol-12-myristate-13-acetate (PMA)-activated neutrophils and macrophages, caerulein or TNFalpha, and activities of trypsin, cathepsin-B and caspase-3 were measured, as well as necrosis using fluorogenic substrates.	Tetradecanoylphorbol Acetate	130-133	cathepsin B	Mus musculus	62-73
8250033-8	1993	A 45-minute incubation of cells with phorbol 12-myristate 13-acetate caused a concentration-dependent decrease in EGF binding that was prevented by a 40-hour, 2 mumol/L pre-exposure to phorbol 12-myristate 13-acetate; 10(-8) mol/L EGF also caused a downregulation of the EGF receptor that was not prevented by phorbol 12-myristate 13-acetate or retinoic acid.	Tetradecanoylphorbol Acetate	185-216	epidermal growth factor	Sus scrofa	231-234
8250033-8	1993	A 45-minute incubation of cells with phorbol 12-myristate 13-acetate caused a concentration-dependent decrease in EGF binding that was prevented by a 40-hour, 2 mumol/L pre-exposure to phorbol 12-myristate 13-acetate; 10(-8) mol/L EGF also caused a downregulation of the EGF receptor that was not prevented by phorbol 12-myristate 13-acetate or retinoic acid.	Tetradecanoylphorbol Acetate	185-216	epidermal growth factor	Sus scrofa	231-234
8243334-3	1993	GnRH action was mimicked by phorbol 12-myristate-13-acetate (PMA), but stimulation of Ca2+ entry by K(+)-induced depolarization and Bay K 8644 was much less effective.	Tetradecanoylphorbol Acetate	28-59	gonadotropin releasing hormone 1	Mus musculus	0-4
24049660-11	2013	The significantly increased postchallenge concentrations of IL-2, IL-8, IL-12p70, IL-13, IL-18, IFN- gamma , TNF- alpha , and TGF- beta were released by peripheral blood cells after stimulation with PMA, as compared with both their prechallenge concentrations and with the PBS control values.	Tetradecanoylphorbol Acetate	199-202	interleukin 18	Homo sapiens	89-94
8243334-3	1993	GnRH action was mimicked by phorbol 12-myristate-13-acetate (PMA), but stimulation of Ca2+ entry by K(+)-induced depolarization and Bay K 8644 was much less effective.	Tetradecanoylphorbol Acetate	61-64	gonadotropin releasing hormone 1	Mus musculus	0-4
23002036-7	2013	Chromatin immunoprecipitation assays were used to identify a 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element (TRE-III) responsible for c-Jun-mediated transcriptional activation of Gipr.	Tetradecanoylphorbol Acetate	61-97	gastric inhibitory polypeptide receptor	Mus musculus	192-196
8245456-4	1993	These cells produce a low level of IL-5 when stimulated with PMA alone; however, N6, O2-dibutyryl cAMP (Bt2cAMP), in combination with PMA, augmented by more than tenfold the IL-5 production at the mRNA and the protein levels.	Tetradecanoylphorbol Acetate	134-137	interleukin 5	Mus musculus	35-39
23002036-7	2013	Chromatin immunoprecipitation assays were used to identify a 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element (TRE-III) responsible for c-Jun-mediated transcriptional activation of Gipr.	Tetradecanoylphorbol Acetate	99-102	gastric inhibitory polypeptide receptor	Mus musculus	192-196
8245456-4	1993	These cells produce a low level of IL-5 when stimulated with PMA alone; however, N6, O2-dibutyryl cAMP (Bt2cAMP), in combination with PMA, augmented by more than tenfold the IL-5 production at the mRNA and the protein levels.	Tetradecanoylphorbol Acetate	134-137	interleukin 5	Mus musculus	174-178
23099255-6	2013	These effects were associated with euphol"s ability to prevent TPA-induced protein kinase C (PKC) activation, namely PKCalpha and PKCdelta isozymes.	Tetradecanoylphorbol Acetate	63-66	protein kinase C, delta	Mus musculus	130-138
8245456-8	1993	In contrast, Bt2cAMP almost completely inhibited the PMA-dependent activation of the endogenous IL-2 gene as well as the transfected IL-2 promoter.	Tetradecanoylphorbol Acetate	53-56	interleukin 2	Mus musculus	96-100
8245456-8	1993	In contrast, Bt2cAMP almost completely inhibited the PMA-dependent activation of the endogenous IL-2 gene as well as the transfected IL-2 promoter.	Tetradecanoylphorbol Acetate	53-56	interleukin 2	Mus musculus	133-137
8246947-7	1993	In contrast, in Swiss 3T3 cells, inhibition of both p21ras activation and TPA-sensitive PKC, but not calcium influx, inhibited EGF-induced ERK2 phosphorylation.	Tetradecanoylphorbol Acetate	74-77	epidermal growth factor	Mus musculus	127-130
23006313-4	2013	Treatment of MSCs with PKC activator, phorbol 12-myristate 13-acetate (PMA), increased cell adhesion and spreading in a dose-dependent method and significantly decreased detachment.	Tetradecanoylphorbol Acetate	38-69	protein kinase C, gamma	Rattus norvegicus	23-26
23006313-4	2013	Treatment of MSCs with PKC activator, phorbol 12-myristate 13-acetate (PMA), increased cell adhesion and spreading in a dose-dependent method and significantly decreased detachment.	Tetradecanoylphorbol Acetate	71-74	protein kinase C, gamma	Rattus norvegicus	23-26
23006313-5	2013	When MSCs were treated with PKC inhibitor, that is, rottlerin, adhesion of MSCs was slightly diminished, and detachment was also decreased compared to the treatment with PMA.	Tetradecanoylphorbol Acetate	170-173	protein kinase C, gamma	Rattus norvegicus	28-31
25275146-10	2014	Administration of 12-O-tetradecanoylphorbol-13-acetate (TPA) markedly increased mice ear oedema and myeloperidase (MPO) activity.	Tetradecanoylphorbol Acetate	18-54	myeloperoxidase	Mus musculus	115-118
25275146-10	2014	Administration of 12-O-tetradecanoylphorbol-13-acetate (TPA) markedly increased mice ear oedema and myeloperidase (MPO) activity.	Tetradecanoylphorbol Acetate	56-59	myeloperoxidase	Mus musculus	115-118
24747121-10	2014	Taken together, sulforaphane inhibits TPA-induced NF-kappaB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKalpha and NAK-IKKbeta.	Tetradecanoylphorbol Acetate	38-41	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	172-180
7693343-4	1993	The TGF-beta 3 protein could be detected immunohistochemically in both dermis and epidermis in control skins and at early times of TPA treatment.	Tetradecanoylphorbol Acetate	131-134	transforming growth factor, beta 3	Mus musculus	4-14
8136266-2	1993	We found that interleukin 4 (IL-4), a T lymphocyte-derived cytokine known to regulate a number of monocyte functions, inhibited the production of TF by monocytes in response to endotoxin and phorbol myristate acetate (PMA) in vitro.	Tetradecanoylphorbol Acetate	191-216	coagulation factor III, tissue factor	Homo sapiens	146-148
24436096-5	2014	In this study, the incidence of skin papillomas induced by 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) in S100a9(-/-) mice has been investigated.	Tetradecanoylphorbol Acetate	135-138	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	143-149
8136266-2	1993	We found that interleukin 4 (IL-4), a T lymphocyte-derived cytokine known to regulate a number of monocyte functions, inhibited the production of TF by monocytes in response to endotoxin and phorbol myristate acetate (PMA) in vitro.	Tetradecanoylphorbol Acetate	218-221	coagulation factor III, tissue factor	Homo sapiens	146-148
23151889-0	2013	Surfactin suppresses TPA-induced breast cancer cell invasion through the inhibition of MMP-9 expression.	Tetradecanoylphorbol Acetate	21-24	matrix metallopeptidase 9	Homo sapiens	87-92
8224278-8	1993	The stimulation by EGF was attenuated by the treatment with genistein, 12-O-tetradecanoylphorbol-13-acetate, or thapsigargin.	Tetradecanoylphorbol Acetate	71-107	epidermal growth factor	Homo sapiens	19-22
23383050-4	2013	We demonstrate simultaneous measurement of miR155 and CD69 in 12-O-tetradecanoylphorbol 13-acetate (PMA) and Ionomycin stimulated Jurkat cells.	Tetradecanoylphorbol Acetate	62-98	microRNA 155	Homo sapiens	43-49
23383050-4	2013	We demonstrate simultaneous measurement of miR155 and CD69 in 12-O-tetradecanoylphorbol 13-acetate (PMA) and Ionomycin stimulated Jurkat cells.	Tetradecanoylphorbol Acetate	100-103	microRNA 155	Homo sapiens	43-49
25000305-0	2014	Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-kappaB activation through MAPK signaling pathways in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	23-26	matrix metallopeptidase 9	Homo sapiens	35-40
25000305-2	2014	The synthesis and secretion of MMP-9 can be stimulated by a variety of stimuli, including cytokines and phorbol 12-myristate 13-acetate (PMA), during various pathological processes, such as tumor invasion, atherosclerosis, inflammation, and rheumatoid arthritis, whereas MMP-2 is usually expressed constitutively.	Tetradecanoylphorbol Acetate	104-135	matrix metallopeptidase 9	Homo sapiens	31-36
25000305-2	2014	The synthesis and secretion of MMP-9 can be stimulated by a variety of stimuli, including cytokines and phorbol 12-myristate 13-acetate (PMA), during various pathological processes, such as tumor invasion, atherosclerosis, inflammation, and rheumatoid arthritis, whereas MMP-2 is usually expressed constitutively.	Tetradecanoylphorbol Acetate	137-140	matrix metallopeptidase 9	Homo sapiens	31-36
25000305-4	2014	In this study, we investigated the antiproliferative and antiinvasive effects of delphinidin on PMA-induced MMP-9 expression in MCF-7 human breast carcinoma cells using zymography, western blotting, reverse transcription-polymerase chain reaction, and Matrigel invasion assay.	Tetradecanoylphorbol Acetate	96-99	matrix metallopeptidase 9	Homo sapiens	108-113
25000305-5	2014	Delphinidin significantly suppressed PMA-induced MMP-9 protein expression in MCF-7 human breast carcinoma cells, and it also inhibited the MMP-9 gene transcriptional activity by blocking the activation of NFkappaB (NF-kappaB) through MAPK signaling pathways.	Tetradecanoylphorbol Acetate	37-40	matrix metallopeptidase 9	Homo sapiens	49-54
7511544-13	1993	12-O-tetradecanoyl phorbol-13-acetate (TPA), a protein kinase regulator, upregulated IGFBP-1 in HFA cultures as determined by RIA, but ACTH was without effect.	Tetradecanoylphorbol Acetate	0-37	insulin like growth factor binding protein 1	Homo sapiens	85-92
25000305-7	2014	These results suggest that delphinidin is a potential antimetastatic agent that suppresses PMA-induced cancer cell invasion through the specific inhibition of NF-kappaB-dependent MMP-9 gene expression.	Tetradecanoylphorbol Acetate	91-94	matrix metallopeptidase 9	Homo sapiens	179-184
23036528-6	2012	The relative amounts of mRNA for TLR4 and MD-2 increased threefold during in vitro activation of the cells with CpG-ODN 2216 but was decreased in cultures stimulated with PMA/ionomycin.	Tetradecanoylphorbol Acetate	171-174	toll like receptor 4	Equus caballus	33-37
7511544-13	1993	12-O-tetradecanoyl phorbol-13-acetate (TPA), a protein kinase regulator, upregulated IGFBP-1 in HFA cultures as determined by RIA, but ACTH was without effect.	Tetradecanoylphorbol Acetate	39-42	insulin like growth factor binding protein 1	Homo sapiens	85-92
7511544-15	1993	IGFBP-3 was downregulated by TPA both at protein and mRNA levels, but it was not affected by ACTH.	Tetradecanoylphorbol Acetate	29-32	insulin like growth factor binding protein 3	Homo sapiens	0-7
25130808-10	2014	The cells treated with both TPA and As2O3 expressed far more CD11b antigens compared with cells exposed to As2O3 alone.	Tetradecanoylphorbol Acetate	28-31	integrin subunit alpha M	Homo sapiens	61-66
8408003-5	1993	Immunoprecipitations revealed the synthesis of IL-11 protein in response to TGF-beta 1, IL-1 beta, as well as phorbol 12-myristate 13-acetate, and a synergistic action of TGF-beta 1 and IL-1 beta was observed.	Tetradecanoylphorbol Acetate	110-141	interleukin 11	Homo sapiens	47-52
23216989-7	2012	In contrast, PMA-induced THP-1 differentiation toward monocytic cells expressed CD11b+, and CD14+, but not CD123, and revealed exclusively IL-12 expression while stimulated by dengue-2.	Tetradecanoylphorbol Acetate	13-16	integrin subunit alpha M	Homo sapiens	80-85
24850301-9	2014	PMA-induced phosphorylation of ERK1/2 signal was also suppressed by blocking CD44.	Tetradecanoylphorbol Acetate	0-3	CD44 molecule (Indian blood group)	Homo sapiens	77-81
7691883-3	1993	Quantitative PCR analysis showed that stimulation with high concentration of KCl, BAY-K 8644, or 12-O-tetradecanoyl phorbol-13-acetate resulted in an immediate and substantial increase (two- to threefold) of Kv1.4 mRNA levels in spontaneously beating myocytes prepared from neonatal rat ventricles.	Tetradecanoylphorbol Acetate	97-134	potassium voltage-gated channel subfamily A member 4	Rattus norvegicus	208-213
24801891-5	2014	Phorbol myristate acetate-stimulated whole blood interleukin (IL)-4, IL-5, IL-10, IL-12, IL-13, IL-17A, IL-17F, IL-22, and interferon-gamma secretory responses were analyzed for associations comparing participants with allergic vs nonallergic asthma phenotypes with those without asthma.	Tetradecanoylphorbol Acetate	0-25	interleukin 10	Homo sapiens	75-80
24801891-5	2014	Phorbol myristate acetate-stimulated whole blood interleukin (IL)-4, IL-5, IL-10, IL-12, IL-13, IL-17A, IL-17F, IL-22, and interferon-gamma secretory responses were analyzed for associations comparing participants with allergic vs nonallergic asthma phenotypes with those without asthma.	Tetradecanoylphorbol Acetate	0-25	interleukin 22	Homo sapiens	112-117
23169635-5	2012	In contrast, PC1(hi) cells produced more IL-10 than PC1(lo) cells when stimulated with LPS and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	95-126	interleukin 10	Homo sapiens	41-46
23169635-5	2012	In contrast, PC1(hi) cells produced more IL-10 than PC1(lo) cells when stimulated with LPS and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	128-131	interleukin 10	Homo sapiens	41-46
22740037-0	2012	Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-kappaB activation in TPA-induced breast cancer cells.	Tetradecanoylphorbol Acetate	119-122	matrix metallopeptidase 9	Homo sapiens	57-62
22740037-3	2012	In the present study, we investigated the inhibitory effects of ar-turmerone on expression and enzymatic activity levels of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase (MMP)-9 and cyclooxygenaase-2 (COX-2) in breast cancer cells.	Tetradecanoylphorbol Acetate	124-160	matrix metallopeptidase 9	Homo sapiens	175-207
24637302-0	2014	PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism.	Tetradecanoylphorbol Acetate	0-3	SKI like proto-oncogene	Homo sapiens	12-16
8376930-8	1993	In lymphoid or p56lck-expressing transfected cells, these effects were preceded by the PMA-induced dissociation of CD4 and p56lck, which released CD4 and made possible increased endocytosis and altered intracellular trafficking.	Tetradecanoylphorbol Acetate	87-90	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	15-21
8376930-8	1993	In lymphoid or p56lck-expressing transfected cells, these effects were preceded by the PMA-induced dissociation of CD4 and p56lck, which released CD4 and made possible increased endocytosis and altered intracellular trafficking.	Tetradecanoylphorbol Acetate	87-90	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	123-129
24962779-6	2014	In a DMBA/TPA-induced mouse skin tumor model, inhibition of Rac1 activity and depletion of CD11b+Gr1+ cells resulted in significant tumor formation.	Tetradecanoylphorbol Acetate	10-13	integrin subunit alpha M	Homo sapiens	91-96
8264664-4	1993	When the TGF beta 1 promoter activity is induced by 12-O-tetradecanoyl phorbol13-acetate (an activator of AP-1-controlled gene transcription), this activity can be strongly repressed by retinoic acid receptor-alpha (RAR alpha), RAR beta, or retinoid X receptor-alpha (RXR alpha) as well as other members of the nuclear receptor family.	Tetradecanoylphorbol Acetate	52-88	retinoic acid receptor alpha	Homo sapiens	186-214
24962779-7	2014	TPA induced recruitment of CD11b+Gr1+ cells into dermis; however, Rac1 inhibitor abolished this recruitment.	Tetradecanoylphorbol Acetate	0-3	integrin subunit alpha M	Homo sapiens	27-32
22740037-3	2012	In the present study, we investigated the inhibitory effects of ar-turmerone on expression and enzymatic activity levels of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase (MMP)-9 and cyclooxygenaase-2 (COX-2) in breast cancer cells.	Tetradecanoylphorbol Acetate	162-165	matrix metallopeptidase 9	Homo sapiens	175-207
22740037-9	2012	Thus, transfection of breast cancer cells with PI3K/Akt and ERK1/2 siRNAs significantly decreased TPA-induced MMP-9 and COX-2 expression.	Tetradecanoylphorbol Acetate	98-101	matrix metallopeptidase 9	Homo sapiens	110-115
22740037-10	2012	These results suggest that ar-turmerone suppressed the TPA-induced up-regulation of MMP-9 and COX-2 expression by blocking NF-kappaB, PI3K/Akt, and ERK1/2 signaling in human breast cancer cells.	Tetradecanoylphorbol Acetate	55-58	matrix metallopeptidase 9	Homo sapiens	84-89
8264664-4	1993	When the TGF beta 1 promoter activity is induced by 12-O-tetradecanoyl phorbol13-acetate (an activator of AP-1-controlled gene transcription), this activity can be strongly repressed by retinoic acid receptor-alpha (RAR alpha), RAR beta, or retinoid X receptor-alpha (RXR alpha) as well as other members of the nuclear receptor family.	Tetradecanoylphorbol Acetate	52-88	retinoic acid receptor alpha	Homo sapiens	216-225
25045647-2	2014	The purpose of this study was to evaluate the relationships between thrombus size on GRE SVS and recanalization after intravenous administration of tissue plasminogen activator (IV-tPA).	Tetradecanoylphorbol Acetate	181-184	chromosome 20 open reading frame 181	Homo sapiens	148-176
8396892-0	1993	Potentiation of CYP1A1 gene expression in MCF-7 human breast cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	129-165	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	16-22
8396892-1	1993	In MCF-7 cells treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 12-O-tetradecanoylphorbol-13-acetate (TPA) causes a time- and concentration-dependent modulation of TCDD-induced CYP1A1 gene expression.	Tetradecanoylphorbol Acetate	72-108	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	185-191
24936444-4	2014	Treatments with hyperglycaemia (25 mM) or phorbol myristate acetate (PMA, a protein kinase C activator, 100 nM) significantly increased NADPH oxidase activity, O2 ( -) generation, proapoptotic protein Bax expression, TUNEL-positive staining and caspase-3/7 activities.	Tetradecanoylphorbol Acetate	42-67	2,4-dienoyl-CoA reductase 1	Homo sapiens	136-141
22986104-3	2012	TPA induced the expression of critical events of tumorigenesis like ornithine decarboxylase, cyclooxygenase-2, interleukin-6 and pSTAT3 in mouse skin after 5h of application, whereas expression of transglutaminase2 was decreased at this time point.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	68-91
24936444-4	2014	Treatments with hyperglycaemia (25 mM) or phorbol myristate acetate (PMA, a protein kinase C activator, 100 nM) significantly increased NADPH oxidase activity, O2 ( -) generation, proapoptotic protein Bax expression, TUNEL-positive staining and caspase-3/7 activities.	Tetradecanoylphorbol Acetate	69-72	2,4-dienoyl-CoA reductase 1	Homo sapiens	136-141
8396892-3	1993	In cells treated with TCDD for 24 h and 100 ng/ml TPA for 26 and 30 h, the TCDD-induced CYP1A1 gene expression was detected.	Tetradecanoylphorbol Acetate	50-53	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	88-94
8396892-4	1993	For example, TCDD-induced EROD activity decreased from 122 pmol/min/mg to 25.5 pmol/min/mg after treatment of MCF-7 cells with TPA for 26 h and this was also paralleled by a 44% decrease in CYP1A1 mRNA levels.	Tetradecanoylphorbol Acetate	127-130	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	190-196
8396892-7	1993	In MCF-7 cells treated with TPA for 36 or 48 h, the TCDD-induced EROD activity and CYP1A1 mRNA levels were restored and in cells exposed to TPA for 72 or 96 h superinducibility of CYP1A1 gene expression was observed; there was a 2.8- and 2.2-fold increase in EROD activity and CYP1A1 mRNA levels, respectively, compared to MCF-7 cells treated with TCDD alone.	Tetradecanoylphorbol Acetate	28-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	83-89
23022525-2	2012	The activation of Protein Kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) can increase ECE-1 phosphorylation, which in turn promotes ECE-1c trafficking to the cell surface where ET-1 production occurs.	Tetradecanoylphorbol Acetate	44-75	endothelin-converting enzyme 1	Cricetulus griseus	95-100
8396892-7	1993	In MCF-7 cells treated with TPA for 36 or 48 h, the TCDD-induced EROD activity and CYP1A1 mRNA levels were restored and in cells exposed to TPA for 72 or 96 h superinducibility of CYP1A1 gene expression was observed; there was a 2.8- and 2.2-fold increase in EROD activity and CYP1A1 mRNA levels, respectively, compared to MCF-7 cells treated with TCDD alone.	Tetradecanoylphorbol Acetate	28-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	180-186
23022525-2	2012	The activation of Protein Kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) can increase ECE-1 phosphorylation, which in turn promotes ECE-1c trafficking to the cell surface where ET-1 production occurs.	Tetradecanoylphorbol Acetate	77-80	endothelin-converting enzyme 1	Cricetulus griseus	95-100
24885456-0	2014	Saussurea lappa extract suppresses TPA-induced cell invasion via inhibition of NF-kappaB-dependent MMP-9 expression in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	35-38	matrix metallopeptidase 9	Homo sapiens	99-104
24885456-13	2014	Therefore, ELS-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of NF-kB pathway in MCF-7 cells.	Tetradecanoylphorbol Acetate	38-41	matrix metallopeptidase 9	Homo sapiens	50-55
24885456-14	2014	CONCLUSIONS: These results indicate that ELS-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of NF-kB pathway in MCF-7 cells.	Tetradecanoylphorbol Acetate	68-71	matrix metallopeptidase 9	Homo sapiens	80-85
24859347-8	2014	Adenoviral over-expression of SIRT1 suppressed PMA and calcium ionophore Ionomycin (PMA/Io)-induced COX-2 expression in human umbilical vein endothelial cells (HUVECs), while SIRT1 RNAi reversed the effects in HUVECs.	Tetradecanoylphorbol Acetate	47-50	sirtuin 1	Homo sapiens	30-35
8396892-7	1993	In MCF-7 cells treated with TPA for 36 or 48 h, the TCDD-induced EROD activity and CYP1A1 mRNA levels were restored and in cells exposed to TPA for 72 or 96 h superinducibility of CYP1A1 gene expression was observed; there was a 2.8- and 2.2-fold increase in EROD activity and CYP1A1 mRNA levels, respectively, compared to MCF-7 cells treated with TCDD alone.	Tetradecanoylphorbol Acetate	28-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	180-186
24604087-8	2014	These results indicate that decursin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKCalpha, MAPK and NF-kappaB pathways in MCF-7 cells.	Tetradecanoylphorbol Acetate	60-63	matrix metallopeptidase 9	Homo sapiens	72-77
8396892-7	1993	In MCF-7 cells treated with TPA for 36 or 48 h, the TCDD-induced EROD activity and CYP1A1 mRNA levels were restored and in cells exposed to TPA for 72 or 96 h superinducibility of CYP1A1 gene expression was observed; there was a 2.8- and 2.2-fold increase in EROD activity and CYP1A1 mRNA levels, respectively, compared to MCF-7 cells treated with TCDD alone.	Tetradecanoylphorbol Acetate	140-143	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	83-89
8396892-7	1993	In MCF-7 cells treated with TPA for 36 or 48 h, the TCDD-induced EROD activity and CYP1A1 mRNA levels were restored and in cells exposed to TPA for 72 or 96 h superinducibility of CYP1A1 gene expression was observed; there was a 2.8- and 2.2-fold increase in EROD activity and CYP1A1 mRNA levels, respectively, compared to MCF-7 cells treated with TCDD alone.	Tetradecanoylphorbol Acetate	140-143	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	180-186
8396892-7	1993	In MCF-7 cells treated with TPA for 36 or 48 h, the TCDD-induced EROD activity and CYP1A1 mRNA levels were restored and in cells exposed to TPA for 72 or 96 h superinducibility of CYP1A1 gene expression was observed; there was a 2.8- and 2.2-fold increase in EROD activity and CYP1A1 mRNA levels, respectively, compared to MCF-7 cells treated with TCDD alone.	Tetradecanoylphorbol Acetate	140-143	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	180-186
24743307-8	2014	In support of this notion, we observed decreased CSB occupancy of TPA-response elements when c-Jun levels were diminished.	Tetradecanoylphorbol Acetate	66-69	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-98
22713854-3	2012	hCG or forskolin+PMA induced the transient increase in Runx1, Ptgs2, and Tnfaip6 expression, while the expression of Runx2 continued to increase until 48 h. The knockdown of the agonist-stimulated Runx2 expression increased Runx1, Ptgs2, and Tnfaip6 expression and PGE(2) levels in luteinizing granulosa cells.	Tetradecanoylphorbol Acetate	17-20	RUNX family transcription factor 1	Rattus norvegicus	55-60
8396892-8	1993	The biphasic temporal effects of TPA on TCDD-induced CYP1A1 gene expression in MCF-7 cells were paralleled by comparable changes in nuclear Ah receptor levels and binding to a synthetic DRE.	Tetradecanoylphorbol Acetate	33-36	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	53-59
8396892-9	1993	In contrast, prolonged exposure of the wild-type Hepa 1c1c7 or T47-D cells to both TCDD plus TPA gave results similar to those observed after 24 h. These data show that the effects of TPA on TCDD-induced expression of CYP1A1 are cell-specific and suggest that the proposed protein kinase C (PKC)-dependent activation of the nuclear Ah receptor complex may not be required in MCF-7 cells since TPA downregulates PKC activity within 11 h and this inactivation persists for at least 96 h.	Tetradecanoylphorbol Acetate	93-96	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	218-224
8396892-9	1993	In contrast, prolonged exposure of the wild-type Hepa 1c1c7 or T47-D cells to both TCDD plus TPA gave results similar to those observed after 24 h. These data show that the effects of TPA on TCDD-induced expression of CYP1A1 are cell-specific and suggest that the proposed protein kinase C (PKC)-dependent activation of the nuclear Ah receptor complex may not be required in MCF-7 cells since TPA downregulates PKC activity within 11 h and this inactivation persists for at least 96 h.	Tetradecanoylphorbol Acetate	184-187	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	218-224
22919060-8	2012	The PKC activator, phorbol-12-myristate-13-acetate (PMA), could mimic the induction of COX-2 and CREB1 phosphorylation.	Tetradecanoylphorbol Acetate	19-50	cAMP responsive element binding protein 1	Homo sapiens	97-102
24532790-0	2014	12-O-tetradecanoylphorbol-13-acetate promotes breast cancer cell motility by increasing S100A14 level in a Kruppel-like transcription factor 4 (KLF4)-dependent manner.	Tetradecanoylphorbol Acetate	0-36	Kruppel like factor 4	Homo sapiens	107-142
8396892-9	1993	In contrast, prolonged exposure of the wild-type Hepa 1c1c7 or T47-D cells to both TCDD plus TPA gave results similar to those observed after 24 h. These data show that the effects of TPA on TCDD-induced expression of CYP1A1 are cell-specific and suggest that the proposed protein kinase C (PKC)-dependent activation of the nuclear Ah receptor complex may not be required in MCF-7 cells since TPA downregulates PKC activity within 11 h and this inactivation persists for at least 96 h.	Tetradecanoylphorbol Acetate	184-187	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	218-224
24532790-0	2014	12-O-tetradecanoylphorbol-13-acetate promotes breast cancer cell motility by increasing S100A14 level in a Kruppel-like transcription factor 4 (KLF4)-dependent manner.	Tetradecanoylphorbol Acetate	0-36	Kruppel like factor 4	Homo sapiens	144-148
24532790-5	2014	Here, we determined that 12-O-tetradecanoylphorbol-13-acetate (TPA) up-regulated the expression of KLF4 and facilitated its binding directly to two conserved GC-rich DNA segments within the S100A14 promoter, which is essential for the transactivation of KLF4 induced S100A14 expression.	Tetradecanoylphorbol Acetate	25-61	Kruppel like factor 4	Homo sapiens	99-103
22919060-8	2012	The PKC activator, phorbol-12-myristate-13-acetate (PMA), could mimic the induction of COX-2 and CREB1 phosphorylation.	Tetradecanoylphorbol Acetate	52-55	cAMP responsive element binding protein 1	Homo sapiens	97-102
22919060-9	2012	The induction of COX-2 by PGF2alpha and PMA could be attenuated by the small interfering RNA-mediated knockdown of CREB1 expression or overexpressing dominant-negative CREB1.	Tetradecanoylphorbol Acetate	40-43	cAMP responsive element binding protein 1	Homo sapiens	115-120
8312133-4	1993	The Ca2+ signal induced by fluoride as well as one induced by EGF was inhibited by the pretreatment of cells with protein kinase C activator, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	142-167	epidermal growth factor	Homo sapiens	62-65
22919060-9	2012	The induction of COX-2 by PGF2alpha and PMA could be attenuated by the small interfering RNA-mediated knockdown of CREB1 expression or overexpressing dominant-negative CREB1.	Tetradecanoylphorbol Acetate	40-43	cAMP responsive element binding protein 1	Homo sapiens	168-173
22919060-10	2012	A chromatin immunoprecipitation assay showed that the binding of CREB1 to the COX-2 promoter was increased by PGF2alpha and PMA in amnion fibroblasts.	Tetradecanoylphorbol Acetate	124-127	cAMP responsive element binding protein 1	Homo sapiens	65-70
24532790-5	2014	Here, we determined that 12-O-tetradecanoylphorbol-13-acetate (TPA) up-regulated the expression of KLF4 and facilitated its binding directly to two conserved GC-rich DNA segments within the S100A14 promoter, which is essential for the transactivation of KLF4 induced S100A14 expression.	Tetradecanoylphorbol Acetate	25-61	Kruppel like factor 4	Homo sapiens	254-258
24532790-5	2014	Here, we determined that 12-O-tetradecanoylphorbol-13-acetate (TPA) up-regulated the expression of KLF4 and facilitated its binding directly to two conserved GC-rich DNA segments within the S100A14 promoter, which is essential for the transactivation of KLF4 induced S100A14 expression.	Tetradecanoylphorbol Acetate	63-66	Kruppel like factor 4	Homo sapiens	99-103
24532790-5	2014	Here, we determined that 12-O-tetradecanoylphorbol-13-acetate (TPA) up-regulated the expression of KLF4 and facilitated its binding directly to two conserved GC-rich DNA segments within the S100A14 promoter, which is essential for the transactivation of KLF4 induced S100A14 expression.	Tetradecanoylphorbol Acetate	63-66	Kruppel like factor 4	Homo sapiens	254-258
24532790-6	2014	Furthermore, stable silencing of KLF4 significantly suppressed breast cancer cell migration induced by TPA.	Tetradecanoylphorbol Acetate	103-106	Kruppel like factor 4	Homo sapiens	33-37
24532790-7	2014	Collectively, these results offer insights into the fact that TPA provokes cell motility through regulating the expression and function of S100A14 in a KLF4-dependent manner.	Tetradecanoylphorbol Acetate	62-65	Kruppel like factor 4	Homo sapiens	152-156
24637716-5	2014	Conversely, THAP11 overexpression accelerated the megakaryocytic differentiation induced by phorbol myristate acetate (PMA) with increased percentage of CD41+ cells, increased numbers of 4N cells, and elevated CD61 mRNA levels, and THAP11 knockdown attenuated the megakaryocytic differentiation.	Tetradecanoylphorbol Acetate	119-122	integrin subunit alpha 2b	Homo sapiens	153-157
8312133-4	1993	The Ca2+ signal induced by fluoride as well as one induced by EGF was inhibited by the pretreatment of cells with protein kinase C activator, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	169-172	epidermal growth factor	Homo sapiens	62-65
8359233-3	1993	The present studies demonstrate that dexamethasone (dex) and cyclosporin A (CsA) resulted in inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced monocytic differentiation of HL60 cells, as well as TPA induction of c-fms and CSF-1 transcripts.	Tetradecanoylphorbol Acetate	145-148	colony stimulating factor 1	Homo sapiens	237-242
23989051-12	2014	Treatment with PMA and ionomycin significantly prevented the decrease in IL-17 but not IL-22 after EtOH exposure and burn injury.	Tetradecanoylphorbol Acetate	15-18	interleukin 17A	Mus musculus	73-78
22804716-5	2012	DAT was distributed between the synaptosomal membrane (60%) and endosomal vesicles (40%), and in vitro application of the protein kinase C activator phorbol 12-myristate 13-acetate to striatal synaptosomes caused DAT internalization into the vesicle fractions.	Tetradecanoylphorbol Acetate	149-180	solute carrier family 6 member 3	Homo sapiens	0-3
22804716-5	2012	DAT was distributed between the synaptosomal membrane (60%) and endosomal vesicles (40%), and in vitro application of the protein kinase C activator phorbol 12-myristate 13-acetate to striatal synaptosomes caused DAT internalization into the vesicle fractions.	Tetradecanoylphorbol Acetate	149-180	solute carrier family 6 member 3	Homo sapiens	213-216
8360264-4	1993	To this end, hsp28 protein expression was examined during phorbol ester (PMA)-induced macrophage differentiation of the human HL-60 promyelocytic leukemic cell line.	Tetradecanoylphorbol Acetate	73-76	heat shock protein family B (small) member 1	Homo sapiens	13-18
23982114-8	2014	ASP(+) uptake by mOCT3 and human OCT3 (hOCT3) was efficiently inhibited by 1-methyl-4-phenylpyridinium, tetrapentylammonium (TPA(+)), corticosterone, serotonin, and histamine and by the drugs ketamine, fluoxetine, and diazepam.	Tetradecanoylphorbol Acetate	125-128	solute carrier family 22 member 3	Homo sapiens	18-22
23982114-8	2014	ASP(+) uptake by mOCT3 and human OCT3 (hOCT3) was efficiently inhibited by 1-methyl-4-phenylpyridinium, tetrapentylammonium (TPA(+)), corticosterone, serotonin, and histamine and by the drugs ketamine, fluoxetine, and diazepam.	Tetradecanoylphorbol Acetate	125-128	solute carrier family 22 member 3	Homo sapiens	39-44
23982114-9	2014	The half maximal inhibitory concentrations of mOCT3 and hOCT3 for TPA(+), serotonin, diazepam, and ketamine are significantly different.	Tetradecanoylphorbol Acetate	66-69	solute carrier family 22 member 3	Homo sapiens	56-61
8360264-5	1993	Whereas hsp28 was constitutively expressed at relatively low levels in an unphosphorylated state, hsp28 was rapidly phosphorylated within 4 hr following PMA-induced differentiation, preceding increased hsp28 protein levels at 24-48 h. In contrast to other differentiative agents, hsp28 steady state mRNA and protein were regulated concordantly in response to macrophage differentiation.	Tetradecanoylphorbol Acetate	153-156	heat shock protein family B (small) member 1	Homo sapiens	98-103
22871965-4	2012	Mithramycin A inhibits Specific Protein (Sp) family member binding to DNA and reduced 1,25(OH)(2)D(3)-induced and PMA-enhanced hCYP24A1 promoter activity.	Tetradecanoylphorbol Acetate	114-117	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	127-135
8360264-5	1993	Whereas hsp28 was constitutively expressed at relatively low levels in an unphosphorylated state, hsp28 was rapidly phosphorylated within 4 hr following PMA-induced differentiation, preceding increased hsp28 protein levels at 24-48 h. In contrast to other differentiative agents, hsp28 steady state mRNA and protein were regulated concordantly in response to macrophage differentiation.	Tetradecanoylphorbol Acetate	153-156	heat shock protein family B (small) member 1	Homo sapiens	98-103
22623726-9	2012	Smurf2 depletion also counteracted the TPA-induced endocytosis and degradation of connexin43.	Tetradecanoylphorbol Acetate	39-42	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	0-6
24239722-1	2014	The role of protein kinase C (PKC) isozymes in phorbol myristate acetate (PMA)-induced sphingosine 1-phosphate (S1P) receptor 1 (S1P1) phosphorylation was studied.	Tetradecanoylphorbol Acetate	47-72	sphingosine-1-phosphate receptor 1	Homo sapiens	87-127
24239722-1	2014	The role of protein kinase C (PKC) isozymes in phorbol myristate acetate (PMA)-induced sphingosine 1-phosphate (S1P) receptor 1 (S1P1) phosphorylation was studied.	Tetradecanoylphorbol Acetate	47-72	sphingosine-1-phosphate receptor 1	Homo sapiens	129-133
8360264-5	1993	Whereas hsp28 was constitutively expressed at relatively low levels in an unphosphorylated state, hsp28 was rapidly phosphorylated within 4 hr following PMA-induced differentiation, preceding increased hsp28 protein levels at 24-48 h. In contrast to other differentiative agents, hsp28 steady state mRNA and protein were regulated concordantly in response to macrophage differentiation.	Tetradecanoylphorbol Acetate	153-156	heat shock protein family B (small) member 1	Homo sapiens	98-103
24239722-1	2014	The role of protein kinase C (PKC) isozymes in phorbol myristate acetate (PMA)-induced sphingosine 1-phosphate (S1P) receptor 1 (S1P1) phosphorylation was studied.	Tetradecanoylphorbol Acetate	74-77	sphingosine-1-phosphate receptor 1	Homo sapiens	87-127
8353279-4	1993	Steady-state levels of prothymosin alpha mRNA, which are high in exponentially growing HL-60, decrease within hours after induction of HL-60 to differentiate along the neutrophil pathway with dimethylsulfoxide (DMSO) or along the macrophage lineage with either tetradecanoylphorbol acetate (TPA) or bryostatin 1.	Tetradecanoylphorbol Acetate	261-289	prothymosin alpha pseudogene 9	Homo sapiens	23-40
24239722-1	2014	The role of protein kinase C (PKC) isozymes in phorbol myristate acetate (PMA)-induced sphingosine 1-phosphate (S1P) receptor 1 (S1P1) phosphorylation was studied.	Tetradecanoylphorbol Acetate	74-77	sphingosine-1-phosphate receptor 1	Homo sapiens	129-133
24239722-2	2014	Activation of S1P1 receptors induced an immediate increase in intracellular calcium, which was blocked by preincubation with PMA.	Tetradecanoylphorbol Acetate	125-128	sphingosine-1-phosphate receptor 1	Homo sapiens	14-18
24239722-7	2014	Additionally, expression of dominant-negative mutants of PKC alpha or beta and knockdown of these isozymes using short hairpin RNA, markedly attenuated PMA-induced S1P1 phosphorylation.	Tetradecanoylphorbol Acetate	152-155	sphingosine-1-phosphate receptor 1	Homo sapiens	164-168
24246502-5	2014	Second, cytokine production upon stimulation with both phorbol 12-myristate 13-acetate/ionomycin and CMV-peptide-loaded antigen-presenting cells was intact in CMV-tetramer(+)CD8(+) T cells.	Tetradecanoylphorbol Acetate	55-86	CD8a molecule	Homo sapiens	174-177
22700433-5	2012	15d-PGJ2-G treatment decreased phorbol 12-myristate 13-acetate (PMA)/calcium ionophore (I0)-induced NFAT DNA binding to the human IL-2 promoter and nuclear NFAT2 accumulation.	Tetradecanoylphorbol Acetate	31-62	nuclear factor of activated T cells 1	Homo sapiens	156-161
22700433-5	2012	15d-PGJ2-G treatment decreased phorbol 12-myristate 13-acetate (PMA)/calcium ionophore (I0)-induced NFAT DNA binding to the human IL-2 promoter and nuclear NFAT2 accumulation.	Tetradecanoylphorbol Acetate	64-67	nuclear factor of activated T cells 1	Homo sapiens	156-161
22643241-3	2012	Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed.	Tetradecanoylphorbol Acetate	31-62	amphiregulin	Homo sapiens	286-298
22643241-3	2012	Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed.	Tetradecanoylphorbol Acetate	64-67	amphiregulin	Homo sapiens	286-298
8353279-4	1993	Steady-state levels of prothymosin alpha mRNA, which are high in exponentially growing HL-60, decrease within hours after induction of HL-60 to differentiate along the neutrophil pathway with dimethylsulfoxide (DMSO) or along the macrophage lineage with either tetradecanoylphorbol acetate (TPA) or bryostatin 1.	Tetradecanoylphorbol Acetate	291-294	prothymosin alpha pseudogene 9	Homo sapiens	23-40
24337742-5	2014	ADAM17 was found to be expressed on NK cells, and stimulation with PMA or N-ethyl-maleimide resulted in the shedding of FcgammaRIIIA/CD16A and CD62L, a specific substrate of ADAM17.	Tetradecanoylphorbol Acetate	67-70	ADAM metallopeptidase domain 17	Homo sapiens	0-6
7688385-8	1993	Treatment of cells with phorbol myristate acetate induced tyrosine phosphorylation of a protein with the same mobility in SDS-PAGE gels as the protein induced after PAF stimulation.	Tetradecanoylphorbol Acetate	24-49	PCNA clamp associated factor	Homo sapiens	165-168
24337742-5	2014	ADAM17 was found to be expressed on NK cells, and stimulation with PMA or N-ethyl-maleimide resulted in the shedding of FcgammaRIIIA/CD16A and CD62L, a specific substrate of ADAM17.	Tetradecanoylphorbol Acetate	67-70	Fc gamma receptor IIIa	Homo sapiens	120-132
24337742-5	2014	ADAM17 was found to be expressed on NK cells, and stimulation with PMA or N-ethyl-maleimide resulted in the shedding of FcgammaRIIIA/CD16A and CD62L, a specific substrate of ADAM17.	Tetradecanoylphorbol Acetate	67-70	Fc gamma receptor IIIa	Homo sapiens	133-138
24337742-5	2014	ADAM17 was found to be expressed on NK cells, and stimulation with PMA or N-ethyl-maleimide resulted in the shedding of FcgammaRIIIA/CD16A and CD62L, a specific substrate of ADAM17.	Tetradecanoylphorbol Acetate	67-70	ADAM metallopeptidase domain 17	Homo sapiens	174-180
22583821-2	2012	CNP mRNA is up-regulated in human vascular smooth muscle cells (SMC) by PDGF-BB via a protein kinase C (PKC)-dependent pathways, and by general PKC activation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	164-189	natriuretic peptide C	Homo sapiens	0-3
22583821-2	2012	CNP mRNA is up-regulated in human vascular smooth muscle cells (SMC) by PDGF-BB via a protein kinase C (PKC)-dependent pathways, and by general PKC activation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	191-194	natriuretic peptide C	Homo sapiens	0-3
8394856-9	1993	The new immunoassay was used to study the mechanisms underlying the release of soluble p55 TNFR from U937 cells stimulated with TPA.	Tetradecanoylphorbol Acetate	128-131	TNF receptor superfamily member 1A	Homo sapiens	87-90
22583821-10	2012	A 8-10-fold greater PMA-induced increase in CNP transcript in SMC than in HAEC suggests that smooth muscle cells could be selectively targeted for CNP up-regulation by PKC-alpha- and PKC-delta-activators.	Tetradecanoylphorbol Acetate	20-23	natriuretic peptide C	Homo sapiens	44-47
22583821-10	2012	A 8-10-fold greater PMA-induced increase in CNP transcript in SMC than in HAEC suggests that smooth muscle cells could be selectively targeted for CNP up-regulation by PKC-alpha- and PKC-delta-activators.	Tetradecanoylphorbol Acetate	20-23	natriuretic peptide C	Homo sapiens	147-150
24706270-8	2014	By stimulation of PBMCs with PMA/ionomycin for 6 h, more than 1-2 % of total CD8 T cells are identified as positive in terms of multifunctionality, thus producing multiple cytokines--IL-2, TNFalpha, and IFNgamma--at single-cell level in case of all healthy donors.	Tetradecanoylphorbol Acetate	29-32	CD8a molecule	Homo sapiens	77-80
24220687-0	2014	Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression.	Tetradecanoylphorbol Acetate	73-76	matrix metallopeptidase 9	Homo sapiens	43-48
24220687-5	2014	The results showed that sanguinarine inhibited TPA-induced MMP-9 and COX-2 mRNA and protein expression in a dose-dependent manner at non-cytotoxic concentrations.	Tetradecanoylphorbol Acetate	47-50	matrix metallopeptidase 9	Homo sapiens	59-64
8394856-9	1993	The new immunoassay was used to study the mechanisms underlying the release of soluble p55 TNFR from U937 cells stimulated with TPA.	Tetradecanoylphorbol Acetate	128-131	TNF receptor superfamily member 1A	Homo sapiens	91-95
8394856-10	1993	The TPA induced release of soluble p55 TNFR from U937 cells occurred in two phases.	Tetradecanoylphorbol Acetate	4-7	TNF receptor superfamily member 1A	Homo sapiens	35-38
22552935-7	2012	alpha-Tocopherol (PKC inhibitor) significantly increased arginine transport in both pregnant and CRF pregnant rats, effects that were attenuated by ex vivo incubation of glomeruli with PMA (a PKC stimulant).	Tetradecanoylphorbol Acetate	185-188	protein kinase C, alpha	Rattus norvegicus	18-21
8394856-10	1993	The TPA induced release of soluble p55 TNFR from U937 cells occurred in two phases.	Tetradecanoylphorbol Acetate	4-7	TNF receptor superfamily member 1A	Homo sapiens	39-43
22552935-7	2012	alpha-Tocopherol (PKC inhibitor) significantly increased arginine transport in both pregnant and CRF pregnant rats, effects that were attenuated by ex vivo incubation of glomeruli with PMA (a PKC stimulant).	Tetradecanoylphorbol Acetate	185-188	protein kinase C, alpha	Rattus norvegicus	192-195
24246425-4	2014	The levels of FosB mRNA and cJun mRNA increased following treatment with forskolin, phorbol-12-myristate-13-acetate (PMA), or A23187 in the hypothalamic cells.	Tetradecanoylphorbol Acetate	84-115	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-18
24246425-4	2014	The levels of FosB mRNA and cJun mRNA increased following treatment with forskolin, phorbol-12-myristate-13-acetate (PMA), or A23187 in the hypothalamic cells.	Tetradecanoylphorbol Acetate	117-120	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-18
8394856-11	1993	First, a rapid increase of soluble p55 was observed after the addition of TPA.	Tetradecanoylphorbol Acetate	74-77	TNF receptor superfamily member 1A	Homo sapiens	35-38
8394856-13	1993	Addition of TPA increased the p55 mRNA expression in U937 cells.	Tetradecanoylphorbol Acetate	12-15	TNF receptor superfamily member 1A	Homo sapiens	30-33
8394856-14	1993	The results suggest that TPA induces both release and new synthesis of p55 in U937 cells.	Tetradecanoylphorbol Acetate	25-28	TNF receptor superfamily member 1A	Homo sapiens	71-74
8348742-1	1993	During the phorbol myristate acetate (PMA)-induced differentiation of U937 cells to a macrophage-like phenotype, the levels of the heat shock proteins hsp90, hsp72 and hsp65 increased dramatically to a peak level following 24 h of treatment, and then declined.	Tetradecanoylphorbol Acetate	11-36	heat shock protein 90 alpha family class A member 1	Homo sapiens	151-156
24340045-4	2013	Multicolour fluorescence analysis of IL-17-expressing peripheral blood mononuclear cells (PBMC) revealed larger proportions of IL-17(+)CD3(-) non-T cells in RA patients than in healthy controls (constitutive, 13.6% vs. 8.4%, and after stimulation with PMA/ionomycin 17.4% vs. 7.9% p &lt; 0.001 in both cases).	Tetradecanoylphorbol Acetate	252-255	interleukin 17A	Homo sapiens	37-42
24353864-10	2013	In addition, SB203580 and MMP-9 I (MMP-9 inhibitor) significantly decreased PMA-induced MUC5B expression.	Tetradecanoylphorbol Acetate	76-79	matrix metallopeptidase 9	Homo sapiens	26-31
24353864-10	2013	In addition, SB203580 and MMP-9 I (MMP-9 inhibitor) significantly decreased PMA-induced MUC5B expression.	Tetradecanoylphorbol Acetate	76-79	matrix metallopeptidase 9	Homo sapiens	35-40
24085323-5	2013	Fibrosarcoma, chondrosarcoma, liposarcoma and synovial sarcoma showed bands corresponding to MMP-2 and MMP-9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	155-186	matrix metallopeptidase 9	Homo sapiens	103-108
24085323-5	2013	Fibrosarcoma, chondrosarcoma, liposarcoma and synovial sarcoma showed bands corresponding to MMP-2 and MMP-9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	155-186	matrix metallopeptidase 9	Homo sapiens	144-149
24085323-5	2013	Fibrosarcoma, chondrosarcoma, liposarcoma and synovial sarcoma showed bands corresponding to MMP-2 and MMP-9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	188-191	matrix metallopeptidase 9	Homo sapiens	103-108
22415432-6	2012	After stimulation with PMA and ionomycin, gammadelta T cells from HBV-ACLF patients produced the greatest amount of TNF-alpha or IL-17 among the three groups.	Tetradecanoylphorbol Acetate	23-26	interleukin 17A	Homo sapiens	129-134
8348742-1	1993	During the phorbol myristate acetate (PMA)-induced differentiation of U937 cells to a macrophage-like phenotype, the levels of the heat shock proteins hsp90, hsp72 and hsp65 increased dramatically to a peak level following 24 h of treatment, and then declined.	Tetradecanoylphorbol Acetate	38-41	heat shock protein 90 alpha family class A member 1	Homo sapiens	151-156
23933110-4	2013	LU8C-FP suppressed TPA-induced MMP-9 and IL-8 secretion and mRNA expression via inhibition of the MAPK signaling pathway and down-regulation of nuclear AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	19-22	matrix metallopeptidase 9	Homo sapiens	31-36
8406581-6	1993	Cells cultured with Con A for 4 days, washed, and restimulated with PMA + ionomycin were unable to express detectable levels of IL-4 and IL-5 mRNA, but produced high levels of IFN-gamma mRNA.	Tetradecanoylphorbol Acetate	68-71	interferon gamma	Rattus norvegicus	176-185
24035999-8	2013	Real-time imaging in MIN6 cells expressing green fluorescent protein-tagged DGKalpha or DGKgamma showed that the DGK activator phorbol 12-myristate 13-acetate rapidly induced translocation of DGKgamma to the plasma membrane, whereas high K(+) slowly translocated DGKalpha and DGKgamma to the plasma membrane.	Tetradecanoylphorbol Acetate	127-158	diacylglycerol kinase, gamma	Mus musculus	263-284
22139477-5	2012	ROMK1 channels pre-incubated with the PKC activator phorbol-12-myristate-13-acetate exhibited increased sensitivity to pH(i) (effective pK(a) shifted to pH approximately 7.0).	Tetradecanoylphorbol Acetate	52-83	potassium inwardly rectifying channel subfamily J member 1 S homeolog	Xenopus laevis	0-5
22586143-4	2012	In a phorbol 12-myristate 13-acetate (PMA)-stimulated pituitary adenoma cell line, AtT-20 cells, we found that the cleavage of L1 was correspondingly enhanced with the increased interaction between Src and Shc.	Tetradecanoylphorbol Acetate	5-36	src homology 2 domain-containing transforming protein C1	Mus musculus	206-209
22586143-4	2012	In a phorbol 12-myristate 13-acetate (PMA)-stimulated pituitary adenoma cell line, AtT-20 cells, we found that the cleavage of L1 was correspondingly enhanced with the increased interaction between Src and Shc.	Tetradecanoylphorbol Acetate	38-41	src homology 2 domain-containing transforming protein C1	Mus musculus	206-209
8227206-3	1993	TPA prevented the accumulation of differentiation markers such as dipeptidylpeptidase IV, villin or mucins, down-regulated the expression of these molecules in post-confluent differentiated cell cultures and induced the loss of the functional integrity of the tight junction in the monolayer (i.e. decreased transepithelial resistance and inhibited dome formation).	Tetradecanoylphorbol Acetate	0-3	dipeptidyl peptidase 4	Homo sapiens	66-88
24118067-8	2013	CONCLUSION: (15R)-PGE2 (1) and (15R)-O-Ac-PGA2 (3) present significant inhibition on three important events related to the topical inflammatory response induced by TPA: the oedema formation, the PMNs degranulation, events that modulate MPO and elastase levels at inflammation site, and the inhibition of the enzyme activity.	Tetradecanoylphorbol Acetate	164-167	myeloperoxidase	Mus musculus	236-239
7689100-4	1993	Pretreatment of A431 cells with phorbol-12-myristate-13-acetate, a protein kinase C activator, blocked PAF-stimulated PLC.	Tetradecanoylphorbol Acetate	32-63	PCNA clamp associated factor	Homo sapiens	103-106
23879967-7	2013	Meanwhile upregulating the [Ca2+]i either by TG or phorbol myristate acetate (PMA) could stimulate the production of MMP-9 in A375 cells with the expression of Basigin.	Tetradecanoylphorbol Acetate	51-76	matrix metallopeptidase 9	Homo sapiens	117-122
23879967-7	2013	Meanwhile upregulating the [Ca2+]i either by TG or phorbol myristate acetate (PMA) could stimulate the production of MMP-9 in A375 cells with the expression of Basigin.	Tetradecanoylphorbol Acetate	78-81	matrix metallopeptidase 9	Homo sapiens	117-122
23940030-6	2013	In addition, FBXO25 overexpression suppressed induction of two ELK-1 target genes, c-fos and egr-1, in response to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	115-146	ETS transcription factor ELK1	Homo sapiens	63-68
22556269-4	2012	METHODS: We assessed TRIM27 expression in human cancer using cancer profiling arrays containing paired tumor and normal cRNA (n = 261) as well as in murine skin cancer induced by 7, 12-dimethylbenzanthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	215-251	tripartite motif containing 27	Homo sapiens	21-27
22556269-4	2012	METHODS: We assessed TRIM27 expression in human cancer using cancer profiling arrays containing paired tumor and normal cRNA (n = 261) as well as in murine skin cancer induced by 7, 12-dimethylbenzanthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	253-256	tripartite motif containing 27	Homo sapiens	21-27
22542663-7	2012	However, treatment of sMCF-7 cells by phorbol 12-myristate 13-acetate (PMA), a PKC activator, induces both tubular network formation and VEGFR-2/VEGFR-3 over-expressions.	Tetradecanoylphorbol Acetate	38-69	kinase insert domain receptor	Homo sapiens	137-144
22542663-7	2012	However, treatment of sMCF-7 cells by phorbol 12-myristate 13-acetate (PMA), a PKC activator, induces both tubular network formation and VEGFR-2/VEGFR-3 over-expressions.	Tetradecanoylphorbol Acetate	38-69	fms related receptor tyrosine kinase 4	Homo sapiens	145-152
22542663-7	2012	However, treatment of sMCF-7 cells by phorbol 12-myristate 13-acetate (PMA), a PKC activator, induces both tubular network formation and VEGFR-2/VEGFR-3 over-expressions.	Tetradecanoylphorbol Acetate	71-74	kinase insert domain receptor	Homo sapiens	137-144
23940030-6	2013	In addition, FBXO25 overexpression suppressed induction of two ELK-1 target genes, c-fos and egr-1, in response to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	115-146	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-88
7689100-4	1993	Pretreatment of A431 cells with phorbol-12-myristate-13-acetate, a protein kinase C activator, blocked PAF-stimulated PLC.	Tetradecanoylphorbol Acetate	32-63	heparan sulfate proteoglycan 2	Homo sapiens	118-121
22542663-7	2012	However, treatment of sMCF-7 cells by phorbol 12-myristate 13-acetate (PMA), a PKC activator, induces both tubular network formation and VEGFR-2/VEGFR-3 over-expressions.	Tetradecanoylphorbol Acetate	71-74	fms related receptor tyrosine kinase 4	Homo sapiens	145-152
23804203-5	2013	In contrast, activation of PKC with phorbol 12-myristate 13-acetate mimicked the inhibitory effect of REV on K(v)2.2 by modifying the activation or inactivation properties of Kv2.2 channels and eliminated any further inhibition by REV.	Tetradecanoylphorbol Acetate	36-67	potassium voltage-gated channel subfamily B member 2	Homo sapiens	175-180
8233727-11	1993	Considering the low proportion of lymphocytes, stimulation with phorbol myristate acetate in combination with ionomycin resulted in considerable production of the following lymphokines: IL-2, IL-3, IL-4, IL-10, interferon-gamma, tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	64-89	interleukin 3	Homo sapiens	192-196
24152593-9	2013	Although expression of BIGH3 did not alter actin polymerization in response to CXCL12, it inhibited the PMA-induced activation of the small GTPase RAC1 as well as the phosphorylation and activation of extracellular-regulated kinases (ERKs).	Tetradecanoylphorbol Acetate	104-107	transforming growth factor beta induced	Homo sapiens	23-28
24152593-9	2013	Although expression of BIGH3 did not alter actin polymerization in response to CXCL12, it inhibited the PMA-induced activation of the small GTPase RAC1 as well as the phosphorylation and activation of extracellular-regulated kinases (ERKs).	Tetradecanoylphorbol Acetate	104-107	Rac family small GTPase 1	Homo sapiens	147-151
8364890-5	1993	Changes in patterns of TPA-inducible, secreted proteins, including those likely to be proliferin, were detected following organotin treatment of confluent monolayers.	Tetradecanoylphorbol Acetate	23-26	prolactin family 2, subfamily c, member 2	Mus musculus	86-96
23660295-6	2013	When stimulated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or CD437, this TR3-TRAPgamma interaction not only induced Ca(2+) depletion in the endoplasmic reticulum (ER) but also promoted the expression of the proapoptotic transcriptional regulator CHOP.	Tetradecanoylphorbol Acetate	21-57	signal sequence receptor subunit 3	Homo sapiens	83-92
23660295-6	2013	When stimulated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or CD437, this TR3-TRAPgamma interaction not only induced Ca(2+) depletion in the endoplasmic reticulum (ER) but also promoted the expression of the proapoptotic transcriptional regulator CHOP.	Tetradecanoylphorbol Acetate	59-62	signal sequence receptor subunit 3	Homo sapiens	83-92
22749038-3	2012	Treatment of 17.94 cells with 12-O-Tetradecanoylphorbol 13-acetate caused morphological changes, which led to reduced NCAM and SALL1 expression, but expression of vimentin was maintained, indicating a potential for stromal differentiation.	Tetradecanoylphorbol Acetate	30-66	spalt like transcription factor 1	Homo sapiens	127-132
22505712-6	2012	Moreover, phorbol myristate acetate enhanced Nedd4-2 phosphorylation and the formation of GLT-1 Nedd4-2 complexes, whereas siRNA knockdown of Nedd4-2 prevented ubiquitination, endocytosis, and the concomitant decrease in GLT-1 activity triggered by PKC activation.	Tetradecanoylphorbol Acetate	10-35	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	45-52
7687618-0	1993	Functionally anergic lpr and gld B220+ T cell receptor (TCR)-alpha/beta+ double-negative T cells express CD28 and respond to costimulation with phorbol myristate acetate and antibodies to CD28 and the TCR.	Tetradecanoylphorbol Acetate	144-169	T cell receptor alpha chain	Mus musculus	39-66
22505712-6	2012	Moreover, phorbol myristate acetate enhanced Nedd4-2 phosphorylation and the formation of GLT-1 Nedd4-2 complexes, whereas siRNA knockdown of Nedd4-2 prevented ubiquitination, endocytosis, and the concomitant decrease in GLT-1 activity triggered by PKC activation.	Tetradecanoylphorbol Acetate	10-35	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	96-103
22505712-6	2012	Moreover, phorbol myristate acetate enhanced Nedd4-2 phosphorylation and the formation of GLT-1 Nedd4-2 complexes, whereas siRNA knockdown of Nedd4-2 prevented ubiquitination, endocytosis, and the concomitant decrease in GLT-1 activity triggered by PKC activation.	Tetradecanoylphorbol Acetate	10-35	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	96-103
23536578-8	2013	In Nanog-expressing human embryonal carcinoma cell lines, NT2/D1 and NCCIT, Nanog expression was suppressed by exposure to PKC activator Phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	137-168	Nanog homeobox	Homo sapiens	3-8
23536578-8	2013	In Nanog-expressing human embryonal carcinoma cell lines, NT2/D1 and NCCIT, Nanog expression was suppressed by exposure to PKC activator Phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	137-168	Nanog homeobox	Homo sapiens	76-81
23536578-8	2013	In Nanog-expressing human embryonal carcinoma cell lines, NT2/D1 and NCCIT, Nanog expression was suppressed by exposure to PKC activator Phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	170-173	Nanog homeobox	Homo sapiens	3-8
7687618-0	1993	Functionally anergic lpr and gld B220+ T cell receptor (TCR)-alpha/beta+ double-negative T cells express CD28 and respond to costimulation with phorbol myristate acetate and antibodies to CD28 and the TCR.	Tetradecanoylphorbol Acetate	144-169	T cell receptor alpha variable 6-3	Mus musculus	56-59
23536578-8	2013	In Nanog-expressing human embryonal carcinoma cell lines, NT2/D1 and NCCIT, Nanog expression was suppressed by exposure to PKC activator Phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	170-173	Nanog homeobox	Homo sapiens	76-81
22534407-1	2012	BACKGROUND: We sought to determine if intravenous tissue plasminogen activator (IV tPA) use for acute ischemic stroke increased in Massachusetts in association with the Primary Stroke Service program, a statewide stroke center designation and quality improvement initiative.	Tetradecanoylphorbol Acetate	83-86	chromosome 20 open reading frame 181	Homo sapiens	50-78
7687618-7	1993	These studies showed that highly purified B220+ TCR-alpha/beta+ DN T cells expressed high levels of CD28, responded weakly to stimulation with PMA and anti-CD28 mAb and quite strongly to PMA, anti-CD28 antibody and high concentrations of immobilized anti-TCR-alpha/beta antibodies.	Tetradecanoylphorbol Acetate	143-146	T cell receptor alpha chain	Mus musculus	48-57
7687618-7	1993	These studies showed that highly purified B220+ TCR-alpha/beta+ DN T cells expressed high levels of CD28, responded weakly to stimulation with PMA and anti-CD28 mAb and quite strongly to PMA, anti-CD28 antibody and high concentrations of immobilized anti-TCR-alpha/beta antibodies.	Tetradecanoylphorbol Acetate	187-190	T cell receptor alpha chain	Mus musculus	48-57
23647419-5	2013	The AP-1 agonist, tetradeconoyl-12,13-phorbol acetate (TPA), also stimulated hTH promoter activity, and Dex and TPA together further accentuated this response.	Tetradecanoylphorbol Acetate	55-58	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-8
8333840-6	1993	In contrast, GnRH and TPA stimulated activin, and to a lesser degree, inhibin production; significantly, this is the first demonstration of activin dimer production by granulosa cells.	Tetradecanoylphorbol Acetate	22-25	inhibin subunit beta E	Homo sapiens	37-44
23647419-5	2013	The AP-1 agonist, tetradeconoyl-12,13-phorbol acetate (TPA), also stimulated hTH promoter activity, and Dex and TPA together further accentuated this response.	Tetradecanoylphorbol Acetate	112-115	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-8
23806369-8	2013	With knockdown of LSD1, H3K4 methylation at IL-6 promoter was found increased after TPA treatment at different times points (all P&lt;0.05, except 24 hours).	Tetradecanoylphorbol Acetate	84-87	lysine demethylase 1A	Homo sapiens	18-22
22250985-4	2012	Upon activation by plate-bound anti-CD3/anti-CD28 or PMA/ionomycin, Fat-1 CD4+ T-cells failed to metabolize PtdIns(4,5)P2.	Tetradecanoylphorbol Acetate	53-56	FAT atypical cadherin 1	Mus musculus	68-73
22250985-4	2012	Upon activation by plate-bound anti-CD3/anti-CD28 or PMA/ionomycin, Fat-1 CD4+ T-cells failed to metabolize PtdIns(4,5)P2.	Tetradecanoylphorbol Acetate	53-56	CD4 antigen	Mus musculus	74-77
8333840-6	1993	In contrast, GnRH and TPA stimulated activin, and to a lesser degree, inhibin production; significantly, this is the first demonstration of activin dimer production by granulosa cells.	Tetradecanoylphorbol Acetate	22-25	inhibin subunit beta E	Homo sapiens	140-147
22258329-5	2012	The induction of S-adenosylmethionine decarboxylase (AdoMetDC) activity and its product decarboxylated AdoMet were impaired in CAG-SpmS mice, and the spermine:spermidine ratio was increased 3-fold in both untreated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated skin.	Tetradecanoylphorbol Acetate	219-255	S-adenosylmethionine decarboxylase 1	Mus musculus	17-51
22258329-5	2012	The induction of S-adenosylmethionine decarboxylase (AdoMetDC) activity and its product decarboxylated AdoMet were impaired in CAG-SpmS mice, and the spermine:spermidine ratio was increased 3-fold in both untreated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated skin.	Tetradecanoylphorbol Acetate	219-255	S-adenosylmethionine decarboxylase 1	Mus musculus	53-61
22258329-5	2012	The induction of S-adenosylmethionine decarboxylase (AdoMetDC) activity and its product decarboxylated AdoMet were impaired in CAG-SpmS mice, and the spermine:spermidine ratio was increased 3-fold in both untreated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated skin.	Tetradecanoylphorbol Acetate	257-260	S-adenosylmethionine decarboxylase 1	Mus musculus	17-51
23563849-10	2013	On gelatinase zymography, A-549 cells showed one band corresponding to MMP-2 and induction of MMP-9 with PMA (100 ng/ml) treatment.	Tetradecanoylphorbol Acetate	105-108	matrix metallopeptidase 9	Homo sapiens	94-99
23563849-11	2013	MSTO-211H showed two bands, an intense band corresponding to MMP-2 and a faint band corresponding to MMP-9; MMP-9 was enhanced significantly with PMA treatment.	Tetradecanoylphorbol Acetate	146-149	matrix metallopeptidase 9	Homo sapiens	101-106
23563849-11	2013	MSTO-211H showed two bands, an intense band corresponding to MMP-2 and a faint band corresponding to MMP-9; MMP-9 was enhanced significantly with PMA treatment.	Tetradecanoylphorbol Acetate	146-149	matrix metallopeptidase 9	Homo sapiens	108-113
8314790-0	1993	Phorbol 12-myristate 13-acetate-induced phosphorylation of Op18 in Jurkat T cells.	Tetradecanoylphorbol Acetate	0-31	stathmin 1	Homo sapiens	59-63
8314790-3	1993	In actively proliferating Jurkat T cells which express Op18 at high level, phorbol 12-myristate 13-acetate (PMA) treatment induces a rapid increase in the level of several Op18 phosphorylated forms.	Tetradecanoylphorbol Acetate	75-106	stathmin 1	Homo sapiens	55-59
22258329-5	2012	The induction of S-adenosylmethionine decarboxylase (AdoMetDC) activity and its product decarboxylated AdoMet were impaired in CAG-SpmS mice, and the spermine:spermidine ratio was increased 3-fold in both untreated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated skin.	Tetradecanoylphorbol Acetate	257-260	S-adenosylmethionine decarboxylase 1	Mus musculus	53-61
8314790-3	1993	In actively proliferating Jurkat T cells which express Op18 at high level, phorbol 12-myristate 13-acetate (PMA) treatment induces a rapid increase in the level of several Op18 phosphorylated forms.	Tetradecanoylphorbol Acetate	75-106	stathmin 1	Homo sapiens	172-176
8314790-3	1993	In actively proliferating Jurkat T cells which express Op18 at high level, phorbol 12-myristate 13-acetate (PMA) treatment induces a rapid increase in the level of several Op18 phosphorylated forms.	Tetradecanoylphorbol Acetate	108-111	stathmin 1	Homo sapiens	55-59
8314790-3	1993	In actively proliferating Jurkat T cells which express Op18 at high level, phorbol 12-myristate 13-acetate (PMA) treatment induces a rapid increase in the level of several Op18 phosphorylated forms.	Tetradecanoylphorbol Acetate	108-111	stathmin 1	Homo sapiens	172-176
24213313-11	2012	MMP-2 and MMP-9 activities were further modulated by phorbol 12-myristate 13-acetate (PMA) induction and inhibited by NM.	Tetradecanoylphorbol Acetate	53-84	matrix metallopeptidase 9	Homo sapiens	10-15
8393277-7	1993	However, unlike in other cell types, AVP stimulated the Na(+)-H+ antiport only simultaneously with a dramatic cell acidification or after treatment with TPA.	Tetradecanoylphorbol Acetate	153-156	arginine vasopressin	Gallus gallus	37-40
24213313-11	2012	MMP-2 and MMP-9 activities were further modulated by phorbol 12-myristate 13-acetate (PMA) induction and inhibited by NM.	Tetradecanoylphorbol Acetate	86-89	matrix metallopeptidase 9	Homo sapiens	10-15
8323287-16	1993	In contrast to the PHS genes expressed in murine (and chicken) fibroblasts in which only the gene coding for the larger mRNA species is transcriptionally regulated, in the rat tracheal cells both genes are positively regulated by TPA and EGF and downregulated by glucocorticoids.	Tetradecanoylphorbol Acetate	230-233	pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1	Mus musculus	19-22
22075471-6	2012	The fundamental subunits of membrane CYBB and cytosolic NCF2 were markedly upregulated after phorbol-12-myristate-13-acetate (PMA) treatment, as detected by quantitative real-time PCR, Western blotting, and immunohistochemistry.	Tetradecanoylphorbol Acetate	93-124	neutrophil cytosolic factor 2	Mus musculus	56-60
7686495-4	1993	When 0.3 ng/ml of phorbol 12-myristate 13-acetate (PMA) was added together with TGF-beta 1, TGF-beta 1 inhibited growth of PC-3 cells (about 50% inhibition), and the growth inhibitory activity of TGF-beta 1 in PC-3U cells was enhanced (more than 90% inhibition).	Tetradecanoylphorbol Acetate	18-49	proprotein convertase subtilisin/kexin type 1	Homo sapiens	123-127
22075471-6	2012	The fundamental subunits of membrane CYBB and cytosolic NCF2 were markedly upregulated after phorbol-12-myristate-13-acetate (PMA) treatment, as detected by quantitative real-time PCR, Western blotting, and immunohistochemistry.	Tetradecanoylphorbol Acetate	126-129	neutrophil cytosolic factor 2	Mus musculus	56-60
7686495-4	1993	When 0.3 ng/ml of phorbol 12-myristate 13-acetate (PMA) was added together with TGF-beta 1, TGF-beta 1 inhibited growth of PC-3 cells (about 50% inhibition), and the growth inhibitory activity of TGF-beta 1 in PC-3U cells was enhanced (more than 90% inhibition).	Tetradecanoylphorbol Acetate	51-54	proprotein convertase subtilisin/kexin type 1	Homo sapiens	123-127
8505299-14	1993	Treatment of the cells with 100 nM 12-O-tetradecanoylphorbol-13-acetate resulted in a 20 +/- 1.2% (mean +/- S.E., p &lt; 0.01, n = 4) increase in the PLA2 activity in the cytosol but failed to increase PLA2 activity in the particulate fraction.	Tetradecanoylphorbol Acetate	35-71	LOC104974671	Bos taurus	150-154
22081309-5	2012	Phorbol 12-myristate 13-acetate-activated granulocytes (CD16(low)/CD66b(++)/CD15(+)) that have a phenotype similar to MDSCs from cancer patients, effectively suppressed both proliferation and cytotoxicity of normal T cells.	Tetradecanoylphorbol Acetate	0-31	Fc gamma receptor IIIa	Homo sapiens	56-60
8099849-6	1993	When activated through the TCR/CD3 pathway, the CD2 pathway, or directly by the phorbol ester, PMA, the memory (CD26+) T cells showed an increased proliferative response that was inhibited by the pkC inhibitor, staurosporine.	Tetradecanoylphorbol Acetate	95-98	dipeptidyl peptidase 4	Homo sapiens	112-116
8495556-7	1993	Stimulation of protein kinase C (PKC) by exposure of quiescent RASMs to phorbol 12-myristate 13-acetate caused a biphasic response in IGF I binding; there was a 42% decrease in receptor number at 45 minutes and a 238% increase at 24 hours.	Tetradecanoylphorbol Acetate	72-103	insulin-like growth factor 1	Rattus norvegicus	134-139
23119229-2	2012	Phosphorylation of the NOX2 cytosolic subunit p47phox is required for phorbol myristate acetate (PMA)-induced NOX2 activation in EBV-transformed B lymphocytes, however the role of this process in receptor-mediated NOX2 activation is not known.	Tetradecanoylphorbol Acetate	70-95	cytochrome b-245 beta chain	Homo sapiens	23-27
23119229-2	2012	Phosphorylation of the NOX2 cytosolic subunit p47phox is required for phorbol myristate acetate (PMA)-induced NOX2 activation in EBV-transformed B lymphocytes, however the role of this process in receptor-mediated NOX2 activation is not known.	Tetradecanoylphorbol Acetate	70-95	neutrophil cytosolic factor 1	Homo sapiens	46-53
23119229-2	2012	Phosphorylation of the NOX2 cytosolic subunit p47phox is required for phorbol myristate acetate (PMA)-induced NOX2 activation in EBV-transformed B lymphocytes, however the role of this process in receptor-mediated NOX2 activation is not known.	Tetradecanoylphorbol Acetate	70-95	cytochrome b-245 beta chain	Homo sapiens	110-114
23119229-2	2012	Phosphorylation of the NOX2 cytosolic subunit p47phox is required for phorbol myristate acetate (PMA)-induced NOX2 activation in EBV-transformed B lymphocytes, however the role of this process in receptor-mediated NOX2 activation is not known.	Tetradecanoylphorbol Acetate	70-95	cytochrome b-245 beta chain	Homo sapiens	110-114
23119229-2	2012	Phosphorylation of the NOX2 cytosolic subunit p47phox is required for phorbol myristate acetate (PMA)-induced NOX2 activation in EBV-transformed B lymphocytes, however the role of this process in receptor-mediated NOX2 activation is not known.	Tetradecanoylphorbol Acetate	97-100	cytochrome b-245 beta chain	Homo sapiens	23-27
23119229-2	2012	Phosphorylation of the NOX2 cytosolic subunit p47phox is required for phorbol myristate acetate (PMA)-induced NOX2 activation in EBV-transformed B lymphocytes, however the role of this process in receptor-mediated NOX2 activation is not known.	Tetradecanoylphorbol Acetate	97-100	neutrophil cytosolic factor 1	Homo sapiens	46-53
8330930-7	1993	Agents that blocked cathepsin G or cathepsin G and elastase completely prevented the proteolysis associated with PMA-stimulated neutrophils, suggesting that the actions of elastase may be dependent on the presence of biologically active cathepsin G.	Tetradecanoylphorbol Acetate	113-116	cathepsin G	Homo sapiens	20-59
23119229-2	2012	Phosphorylation of the NOX2 cytosolic subunit p47phox is required for phorbol myristate acetate (PMA)-induced NOX2 activation in EBV-transformed B lymphocytes, however the role of this process in receptor-mediated NOX2 activation is not known.	Tetradecanoylphorbol Acetate	97-100	cytochrome b-245 beta chain	Homo sapiens	110-114
8330930-7	1993	Agents that blocked cathepsin G or cathepsin G and elastase completely prevented the proteolysis associated with PMA-stimulated neutrophils, suggesting that the actions of elastase may be dependent on the presence of biologically active cathepsin G.	Tetradecanoylphorbol Acetate	113-116	cathepsin G	Homo sapiens	20-31
23119229-2	2012	Phosphorylation of the NOX2 cytosolic subunit p47phox is required for phorbol myristate acetate (PMA)-induced NOX2 activation in EBV-transformed B lymphocytes, however the role of this process in receptor-mediated NOX2 activation is not known.	Tetradecanoylphorbol Acetate	97-100	cytochrome b-245 beta chain	Homo sapiens	110-114
8396623-3	1993	ACTH enhanced IGF-II mRNA accumulation dose- and time-dependently, maximally four- to sixfold, and this increase was inhibited dose-dependently (0.01-100 micrograms/l) by 12-O-tetradecanoyl phorbol-13-acetate (TPA), a PKC activator.	Tetradecanoylphorbol Acetate	171-208	insulin like growth factor 2	Homo sapiens	14-20
8396623-3	1993	ACTH enhanced IGF-II mRNA accumulation dose- and time-dependently, maximally four- to sixfold, and this increase was inhibited dose-dependently (0.01-100 micrograms/l) by 12-O-tetradecanoyl phorbol-13-acetate (TPA), a PKC activator.	Tetradecanoylphorbol Acetate	210-213	insulin like growth factor 2	Homo sapiens	14-20
8396623-4	1993	TPA decreased basal IGF-II mRNA levels by approximately 55%.	Tetradecanoylphorbol Acetate	0-3	insulin like growth factor 2	Homo sapiens	20-26
21377232-2	2012	The binding of AP-1 proteins to the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element can activate target genes and regulate many critical cellular processes.	Tetradecanoylphorbol Acetate	36-72	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-19
8396623-8	1993	TPA, although it decreased IGF-II mRNA levels, tended to increase IGF-II peptide in the medium.	Tetradecanoylphorbol Acetate	0-3	insulin like growth factor 2	Homo sapiens	27-33
21377232-2	2012	The binding of AP-1 proteins to the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element can activate target genes and regulate many critical cellular processes.	Tetradecanoylphorbol Acetate	74-77	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-19
7684374-3	1993	We have isolated human cDNA clones encoding glyoxalase I from a phorbol myristate acetate-treated U937 cDNA library.	Tetradecanoylphorbol Acetate	64-89	glyoxalase I	Homo sapiens	44-56
21975875-6	2012	Broad PKC inhibitors (PMA, bisindolylmaleimide, Go6976), as well as specific PKCbeta blockade with an inhibitor and small interfering RNA (siRNA), prevented RhoA activation by glucose.	Tetradecanoylphorbol Acetate	22-25	ras homolog family member A	Rattus norvegicus	157-161
8322268-8	1993	With such high PAI-Fx available to bind tPA, occlusion-stimulated tPA-Fx could not rise, and fibrinolysis could not be initiated.	Tetradecanoylphorbol Acetate	66-69	serpin family B member 2	Homo sapiens	15-18
8388649-10	1993	Addition of H(+)-ATPase inhibitors, NBD-Cl or bafilomycin, following PMA stimulation or acid loading, inhibited pHi restoration.	Tetradecanoylphorbol Acetate	69-72	glucose-6-phosphate isomerase	Rattus norvegicus	112-115
22414682-5	2012	RESULTS: The levels of IL-8 and GRO-alpha were significantly increased after treatment with EGF, TGF-alpha, TNF-alpha and TPA by primary cultured granulosa-lutein cells.	Tetradecanoylphorbol Acetate	122-125	C-X-C motif chemokine ligand 1	Homo sapiens	32-41
8389299-2	1993	The regulation of low-density-lipoprotein(LDL)-receptor activity by 4 beta-phorbol 12-myristate 13-acetate (PMA) and LDL was investigated in the human hepatoma cell line Hep G2.	Tetradecanoylphorbol Acetate	68-106	low density lipoprotein receptor	Homo sapiens	42-55
23056468-9	2012	In addition, ING4 suppressed PMA-induced cell invasion and NF-kappaB-target gene expression in T47D cells, indicating that ING4 inhibited NF-kappaB activity in breast cancer cells.	Tetradecanoylphorbol Acetate	29-32	inhibitor of growth family member 4	Homo sapiens	13-17
23056468-9	2012	In addition, ING4 suppressed PMA-induced cell invasion and NF-kappaB-target gene expression in T47D cells, indicating that ING4 inhibited NF-kappaB activity in breast cancer cells.	Tetradecanoylphorbol Acetate	29-32	inhibitor of growth family member 4	Homo sapiens	123-127
8389299-2	1993	The regulation of low-density-lipoprotein(LDL)-receptor activity by 4 beta-phorbol 12-myristate 13-acetate (PMA) and LDL was investigated in the human hepatoma cell line Hep G2.	Tetradecanoylphorbol Acetate	108-111	low density lipoprotein receptor	Homo sapiens	42-55
8389730-0	1993	Contrasting effects of two tumour promoters, phorbol myristate acetate and okadaic acid, on T-cell responses and activation of p42 MAP-kinase/ERK-2.	Tetradecanoylphorbol Acetate	45-70	cyclin dependent kinase 20	Homo sapiens	127-130
22006917-5	2011	Here, we report that serine 44 in the N-terminal head domain of K17 (K17-Ser(44)) is phosphorylated in response to extracellular stimuli (serum, EGF, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate) that alter skin keratinocyte growth, and to cellular stresses (sorbitol-induced hyperosmotic shock, UV irradiation, and hydrogen peroxide-induced oxidative stress).	Tetradecanoylphorbol Acetate	172-208	keratin 17	Mus musculus	64-67
8389730-8	1993	PMA induced a 42,000 MW tyrosine phosphoprotein which co-electrophoresed and co-chromatographed with ERK-2, a p42 MAP-kinase.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase 20	Homo sapiens	110-113
22006917-5	2011	Here, we report that serine 44 in the N-terminal head domain of K17 (K17-Ser(44)) is phosphorylated in response to extracellular stimuli (serum, EGF, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate) that alter skin keratinocyte growth, and to cellular stresses (sorbitol-induced hyperosmotic shock, UV irradiation, and hydrogen peroxide-induced oxidative stress).	Tetradecanoylphorbol Acetate	172-208	keratin 17	Mus musculus	69-80
8314909-2	1993	12-o-tetradecanoyl 13-phorbol acetate (TPA) differentiated them to macrophage-like cells with induction of MMP-9, and tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) stimulated the production of MMP-9 by TPA-treated cells.	Tetradecanoylphorbol Acetate	39-42	interleukin 1 alpha	Homo sapiens	162-181
8314909-2	1993	12-o-tetradecanoyl 13-phorbol acetate (TPA) differentiated them to macrophage-like cells with induction of MMP-9, and tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) stimulated the production of MMP-9 by TPA-treated cells.	Tetradecanoylphorbol Acetate	39-42	interleukin 1 alpha	Homo sapiens	183-193
8102878-4	1993	Induction of dermatitis by topical application of PMA increased the expression of Ly-6.A2 on TCR gamma delta+ dendritic epidermal T cells and did not change its expression on keratinocytes.	Tetradecanoylphorbol Acetate	50-53	T cell receptor alpha variable 6-3	Mus musculus	93-96
21810446-9	2011	PKCtheta inhibition (by pseudostrate-inhibitor or dominant negative) inhibited CCK- and TPA-stimulation of PKD, Src, RafC, PYK2, p125(FAK) and IKKalpha/beta, but not basal/stimulated enzyme secretion.	Tetradecanoylphorbol Acetate	88-91	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	112-115
22160590-5	2011	Treatment with TPA modified the activity of phosphoPKCalpha and caused an increase of the Snail family members Snail, Slug and Smad-interacting protein 1 and a decrease of E-cadherin.	Tetradecanoylphorbol Acetate	15-18	snail family transcriptional repressor 2	Homo sapiens	118-122
22160590-6	2011	In HPAC cells treated with TPA, downregulation of claudin-1 and mislocalization of claudin-4 and occludin around the nuclei were observed, together with a decrease in the numbers of tight junction strands and an increase in phosphorylation of claudin-4.	Tetradecanoylphorbol Acetate	27-30	claudin 1	Homo sapiens	50-59
8496339-3	1993	We studied the effects of phytohemagglutinin (PHA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) on the biosynthesis of CRH in human T-lymphocyte cell cultures.	Tetradecanoylphorbol Acetate	55-91	corticotropin releasing hormone	Homo sapiens	121-124
8496339-3	1993	We studied the effects of phytohemagglutinin (PHA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) on the biosynthesis of CRH in human T-lymphocyte cell cultures.	Tetradecanoylphorbol Acetate	93-96	corticotropin releasing hormone	Homo sapiens	121-124
8496339-4	1993	A significant increase in CRH mRNA levels was observed in human lymphocytes after 12 h of PHA/TPA treatment, while the levels decreased after 22 h. These findings could imply an immunomodulatory role for CRH that could be due to autocrine and/or paracrine interactions.	Tetradecanoylphorbol Acetate	94-97	corticotropin releasing hormone	Homo sapiens	26-29
8496339-4	1993	A significant increase in CRH mRNA levels was observed in human lymphocytes after 12 h of PHA/TPA treatment, while the levels decreased after 22 h. These findings could imply an immunomodulatory role for CRH that could be due to autocrine and/or paracrine interactions.	Tetradecanoylphorbol Acetate	94-97	corticotropin releasing hormone	Homo sapiens	204-207
22000935-17	2011	In addition, all compounds except chemical 15, significantly reduced neutrophil infiltration, measured as myeloperoxidase activity on TPA application test.	Tetradecanoylphorbol Acetate	134-137	myeloperoxidase	Mus musculus	106-121
8449942-7	1993	Stimulation of murine bone marrow macrophages by mediators of inflammation, such as lipopolysaccharide, phorbol 12-myristate 13-acetate, interleukin-1, and interferon-gamma resulted in the reduced expression of fli-1 mRNA.	Tetradecanoylphorbol Acetate	104-135	Friend leukemia integration 1	Mus musculus	211-216
21400615-4	2011	Western blot analysis revealed that 5"-NIO inhibited activities of Raf-1 (S338), MEK1/2, ERK1/2, JNK, and c-Jun induced by EGF or TPA, respectively, whereas it did not affect autophosphorylation of epidermal growth factor receptor (EGFR) induced by EGF or TPA.	Tetradecanoylphorbol Acetate	130-133	v-raf-leukemia viral oncogene 1	Mus musculus	67-72
21400615-4	2011	Western blot analysis revealed that 5"-NIO inhibited activities of Raf-1 (S338), MEK1/2, ERK1/2, JNK, and c-Jun induced by EGF or TPA, respectively, whereas it did not affect autophosphorylation of epidermal growth factor receptor (EGFR) induced by EGF or TPA.	Tetradecanoylphorbol Acetate	130-133	mitogen-activated protein kinase 8	Mus musculus	97-100
8439961-7	1993	To determine the level of regulation of the Epo-R gene, its rate of transcription was measured by nuclear run-off assay in untreated cells and in cells exposed to PMA for 6, 12, and 24 h. The rate of transcription was nearly identical at all time points in control and PMA-treated cells.	Tetradecanoylphorbol Acetate	163-166	erythropoietin receptor	Homo sapiens	44-49
8439961-7	1993	To determine the level of regulation of the Epo-R gene, its rate of transcription was measured by nuclear run-off assay in untreated cells and in cells exposed to PMA for 6, 12, and 24 h. The rate of transcription was nearly identical at all time points in control and PMA-treated cells.	Tetradecanoylphorbol Acetate	269-272	erythropoietin receptor	Homo sapiens	44-49
21633078-3	2011	In the HSG cells stably transfected with a wild-type mouse AQP5 construct, a protein band immunoreactive with antibody against phosphorylated PKA substrate was detected in the AQP5 immunoprecipitated sample, and its intensity was enhanced by short-term treatment of the cells with 8-bromo-cAMP, forskolin, or phorbol 12-myristate 13-acetate, but not by that with A23187 calcium ionophore.	Tetradecanoylphorbol Acetate	309-340	aquaporin 5	Mus musculus	59-63
23456480-4	2013	We studied the effects of DetaNONOate (10-400 muM) or SNAP (50-400 muM) on phorbol 12-myristate 13-acetate (PMA; 10 nM)-induced increases in MMP-9 activity (by gel zymography) or concentrations (by ELISA) as well as on a tissue inhibitor of MMPs" (TIMP)-1 concentrations (by ELISA) in the conditioned medium of HUVECs incubated for 24 h with these drugs.	Tetradecanoylphorbol Acetate	75-106	matrix metallopeptidase 9	Homo sapiens	141-146
21804018-4	2011	Moreover, PMA-induced IL-1beta production was significantly reduced in the presence of TLR2, TLR4, and CD11b Abs.	Tetradecanoylphorbol Acetate	10-13	integrin subunit alpha M	Homo sapiens	103-108
8436597-3	1993	Northern blot analysis revealed that LPS increased IL-8 mRNA levels in neutrophils, with a maximal fivefold increase by 2 h. IL-8 mRNa levels returned to baseline values within 12 h. In contrast, LPS-stimulated monocytes demonstrated a sustained increase of IL-8 mRNA levels for more than 24 h. TNF-alpha, IL-1 beta, and phorbol myristate acetate also increased IL-8 mRNA levels in neutrophils.	Tetradecanoylphorbol Acetate	321-346	interferon regulatory factor 6	Homo sapiens	37-40
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	43-79	cAMP responsive element binding protein 1	Homo sapiens	159-163
23456480-4	2013	We studied the effects of DetaNONOate (10-400 muM) or SNAP (50-400 muM) on phorbol 12-myristate 13-acetate (PMA; 10 nM)-induced increases in MMP-9 activity (by gel zymography) or concentrations (by ELISA) as well as on a tissue inhibitor of MMPs" (TIMP)-1 concentrations (by ELISA) in the conditioned medium of HUVECs incubated for 24 h with these drugs.	Tetradecanoylphorbol Acetate	108-111	matrix metallopeptidase 9	Homo sapiens	141-146
23456480-5	2013	We also examined whether the irreversible inhibitor of soluble guanylyl cyclase ODQ modified the effects of SNAP or whether 8-bromo-cGMP (a cell-permeable analog of cGMP) influenced PMA-induced effects on MMP-9 expression.	Tetradecanoylphorbol Acetate	182-185	matrix metallopeptidase 9	Homo sapiens	205-210
21705328-0	2011	Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.	Tetradecanoylphorbol Acetate	81-84	cAMP responsive element binding protein 1	Homo sapiens	159-163
8436597-3	1993	Northern blot analysis revealed that LPS increased IL-8 mRNA levels in neutrophils, with a maximal fivefold increase by 2 h. IL-8 mRNa levels returned to baseline values within 12 h. In contrast, LPS-stimulated monocytes demonstrated a sustained increase of IL-8 mRNA levels for more than 24 h. TNF-alpha, IL-1 beta, and phorbol myristate acetate also increased IL-8 mRNA levels in neutrophils.	Tetradecanoylphorbol Acetate	321-346	interferon regulatory factor 6	Homo sapiens	196-199
21705328-1	2011	12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors.	Tetradecanoylphorbol Acetate	0-36	cAMP responsive element binding protein 1	Homo sapiens	246-285
21705328-1	2011	12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors.	Tetradecanoylphorbol Acetate	0-36	cAMP responsive element binding protein 1	Homo sapiens	287-291
21705328-1	2011	12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors.	Tetradecanoylphorbol Acetate	38-41	cAMP responsive element binding protein 1	Homo sapiens	246-285
8387623-9	1993	The specificity of the TPA effect was evaluated with the following test agents: 0.2 nmol/L epidermal growth factor (EGF), 0.1 mumol/L 4 alpha-TPA (a stereoisomer of TPA), or 1.0 mumol/L A23187.	Tetradecanoylphorbol Acetate	23-26	epidermal growth factor	Canis lupus familiaris	91-114
21705328-1	2011	12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP-responsive element-binding protein (CREB)-1/ATF-1-like factors.	Tetradecanoylphorbol Acetate	38-41	cAMP responsive element binding protein 1	Homo sapiens	287-291
23526078-8	2013	Proliferation of ACHN cells was concentration dependent in the presence of PMA and calphostin C. Netrin-1 and UNC5B expressions were upregulated in cells treated with PMA while calphostin C reversed this upregulation.	Tetradecanoylphorbol Acetate	75-78	netrin 1	Homo sapiens	97-105
23526078-8	2013	Proliferation of ACHN cells was concentration dependent in the presence of PMA and calphostin C. Netrin-1 and UNC5B expressions were upregulated in cells treated with PMA while calphostin C reversed this upregulation.	Tetradecanoylphorbol Acetate	75-78	unc-5 netrin receptor B	Homo sapiens	110-115
23526078-10	2013	Our data highly suggested that PMA-induced upregulation and calphostin C-induced reversion of netrin-1 and UNC5B in kidney carcinoma were accompanied by the activation of the netrin-1/UNC5B pathways.	Tetradecanoylphorbol Acetate	31-34	netrin 1	Homo sapiens	175-183
23526078-10	2013	Our data highly suggested that PMA-induced upregulation and calphostin C-induced reversion of netrin-1 and UNC5B in kidney carcinoma were accompanied by the activation of the netrin-1/UNC5B pathways.	Tetradecanoylphorbol Acetate	31-34	unc-5 netrin receptor B	Homo sapiens	184-189
21705328-4	2011	Small interfering RNA (siRNA) experiments indicated that knocking down the NADPH oxidase components e.g. Rac1, p22(phox), p67(phox), and NOXO1 in A549 cells impaired TPA-induced MnSOD expression.	Tetradecanoylphorbol Acetate	166-169	Rac family small GTPase 1	Homo sapiens	105-109
8387623-9	1993	The specificity of the TPA effect was evaluated with the following test agents: 0.2 nmol/L epidermal growth factor (EGF), 0.1 mumol/L 4 alpha-TPA (a stereoisomer of TPA), or 1.0 mumol/L A23187.	Tetradecanoylphorbol Acetate	23-26	epidermal growth factor	Canis lupus familiaris	116-119
21705328-7	2011	Furthermore, siRNA-induced knock-down of CREB and Forkhead box class O (FOXO) 3a led to a reduction in TPA-induced MnSOD gene expression.	Tetradecanoylphorbol Acetate	103-106	cAMP responsive element binding protein 1	Homo sapiens	41-45
24276261-3	2013	In this brief report, we investigate the potential involvement of CaV2 VDCC subtypes in functional effects of the phorbol ester, phorbol 12-myristate 13-acetate (PMA) on nociceptive transmission in the spinal cord.	Tetradecanoylphorbol Acetate	129-160	caveolin 2	Mus musculus	66-70
8441379-7	1993	When ligated to the murine c-fos promoter, however, the proIL-1 beta enhancer was inducible in phorbol myristate acetate-stimulated HeLa cells, suggesting the existence of a proIL-1 beta promoter-proximal requirement for tissue specificity.	Tetradecanoylphorbol Acetate	95-120	FBJ osteosarcoma oncogene	Mus musculus	27-32
7679006-3	1993	However, in the presence of optimal concentrations of granulocyte colony-stimulating factor (G-CSF) or interleukin-6 (IL-6), TPA or bryostatin markedly elevated the number of colonies formed from the GM-CFC.	Tetradecanoylphorbol Acetate	125-128	colony stimulating factor 3	Homo sapiens	54-91
23528267-2	2013	Rat primary cultures of DRG neurons were stimulated with phorbol-12-myristate-13-acetate (PMA), a potent activator of protein kinase C (PKC), which resulted in the robust expression of both BDNF mRNA and protein.	Tetradecanoylphorbol Acetate	90-93	protein kinase C, gamma	Rattus norvegicus	118-134
23528267-2	2013	Rat primary cultures of DRG neurons were stimulated with phorbol-12-myristate-13-acetate (PMA), a potent activator of protein kinase C (PKC), which resulted in the robust expression of both BDNF mRNA and protein.	Tetradecanoylphorbol Acetate	90-93	protein kinase C, gamma	Rattus norvegicus	136-139
23528267-2	2013	Rat primary cultures of DRG neurons were stimulated with phorbol-12-myristate-13-acetate (PMA), a potent activator of protein kinase C (PKC), which resulted in the robust expression of both BDNF mRNA and protein.	Tetradecanoylphorbol Acetate	90-93	brain-derived neurotrophic factor	Rattus norvegicus	190-194
21525431-8	2011	Furthermore, the PKC activator phorbol 12-myristate 13-acetate (PMA), but not its analog 4alpha-phorbol 12, 13-didecanoate (4alpha-PDD), suppressed TRPC6 expression, and this PMA effect was not affected by catalase.	Tetradecanoylphorbol Acetate	31-62	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	148-153
21525431-8	2011	Furthermore, the PKC activator phorbol 12-myristate 13-acetate (PMA), but not its analog 4alpha-phorbol 12, 13-didecanoate (4alpha-PDD), suppressed TRPC6 expression, and this PMA effect was not affected by catalase.	Tetradecanoylphorbol Acetate	64-67	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	148-153
7679006-3	1993	However, in the presence of optimal concentrations of granulocyte colony-stimulating factor (G-CSF) or interleukin-6 (IL-6), TPA or bryostatin markedly elevated the number of colonies formed from the GM-CFC.	Tetradecanoylphorbol Acetate	125-128	colony stimulating factor 3	Homo sapiens	93-99
8381412-4	1993	Two-dimensional phosphopeptide mapping shows that the same sites in TnI are modified by PKC in vitro and in TPA- or alpha-agonist-stimulated cells.	Tetradecanoylphorbol Acetate	108-111	troponin I3, cardiac type	Rattus norvegicus	68-71
21533871-1	2011	The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	95-126	epilepsy 4	Mus musculus	11-14
21533871-1	2011	The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	128-131	epilepsy 4	Mus musculus	11-14
23114726-7	2013	The treatment of specific inhibitor for ERK (U0126) to MCF-7 cells could inhibit TPA-induced MMP-2/MMP-9 and phospho-ERK along with an inhibition on cell invasion and migration.	Tetradecanoylphorbol Acetate	81-84	matrix metallopeptidase 9	Homo sapiens	99-104
8426746-6	1993	Comparison of the findings with those for the promoters of other TPA-inducible matrix metalloproteinases, interstitial collagenase and stromelysin 1, revealed that the signal to the AP-1 sites is common for the TPA-inducibility of the genes but that the signals to the kappa B or Sp-1 sites, which are not present in interstitial collagenase and stromelysin 1 promoters, are the unique determinant for the inducibility of the 92 kDa type IV collagenase gene.	Tetradecanoylphorbol Acetate	65-68	matrix metallopeptidase 1	Homo sapiens	106-130
8426746-6	1993	Comparison of the findings with those for the promoters of other TPA-inducible matrix metalloproteinases, interstitial collagenase and stromelysin 1, revealed that the signal to the AP-1 sites is common for the TPA-inducibility of the genes but that the signals to the kappa B or Sp-1 sites, which are not present in interstitial collagenase and stromelysin 1 promoters, are the unique determinant for the inducibility of the 92 kDa type IV collagenase gene.	Tetradecanoylphorbol Acetate	65-68	matrix metallopeptidase 1	Homo sapiens	317-341
23643258-4	2013	Moreover, IFN-gamma, IL-4, IL-9 and IL-17 secreted by gammadeltaT cells were detected by means of intracellular cytokine staining after stimulation with PMA plus ionomycin.	Tetradecanoylphorbol Acetate	153-156	interleukin 9	Mus musculus	27-31
23643258-4	2013	Moreover, IFN-gamma, IL-4, IL-9 and IL-17 secreted by gammadeltaT cells were detected by means of intracellular cytokine staining after stimulation with PMA plus ionomycin.	Tetradecanoylphorbol Acetate	153-156	interleukin 17A	Mus musculus	36-41
23377348-8	2013	MARCKS translocated rapidly from plasma membrane to cytoplasm, whereas HSP70 was observed in the cytoplasm and appeared to associate with MARCKS after PMA exposure.	Tetradecanoylphorbol Acetate	151-154	heat shock protein family A (Hsp70) member 4	Homo sapiens	71-76
21354279-0	2011	Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCalpha/ERK1/2-dependent matrix metalloproteinase-9 expression.	Tetradecanoylphorbol Acetate	15-46	matrix metallopeptidase 9	Homo sapiens	135-161
21354279-4	2011	We found that piperine suppresses PMA-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB and AP-1 activation without changing the level of tissue inhibitor of metalloproteinase (TIMP)-1.	Tetradecanoylphorbol Acetate	34-37	matrix metallopeptidase 9	Homo sapiens	47-73
21354279-4	2011	We found that piperine suppresses PMA-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB and AP-1 activation without changing the level of tissue inhibitor of metalloproteinase (TIMP)-1.	Tetradecanoylphorbol Acetate	34-37	matrix metallopeptidase 9	Homo sapiens	75-80
8426746-6	1993	Comparison of the findings with those for the promoters of other TPA-inducible matrix metalloproteinases, interstitial collagenase and stromelysin 1, revealed that the signal to the AP-1 sites is common for the TPA-inducibility of the genes but that the signals to the kappa B or Sp-1 sites, which are not present in interstitial collagenase and stromelysin 1 promoters, are the unique determinant for the inducibility of the 92 kDa type IV collagenase gene.	Tetradecanoylphorbol Acetate	211-214	matrix metallopeptidase 1	Homo sapiens	106-130
23615261-0	2013	Sulforaphane controls TPA-induced MMP-9 expression through the NF-kappaB signaling pathway, but not AP-1, in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	22-25	matrix metallopeptidase 9	Homo sapiens	34-39
8426746-6	1993	Comparison of the findings with those for the promoters of other TPA-inducible matrix metalloproteinases, interstitial collagenase and stromelysin 1, revealed that the signal to the AP-1 sites is common for the TPA-inducibility of the genes but that the signals to the kappa B or Sp-1 sites, which are not present in interstitial collagenase and stromelysin 1 promoters, are the unique determinant for the inducibility of the 92 kDa type IV collagenase gene.	Tetradecanoylphorbol Acetate	211-214	matrix metallopeptidase 1	Homo sapiens	317-341
23615261-4	2013	In this study, we investigated the effect of sulforaphane on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells.	Tetradecanoylphorbol Acetate	61-98	matrix metallopeptidase 9	Homo sapiens	113-118
8381280-2	1993	Dibutyryl-cAMP, forskolin, staurosporine and phorbol 12-myristate 13-acetate were all found to mimic the cytostatic action of IL-1 on K562 cells.	Tetradecanoylphorbol Acetate	45-76	interleukin 1 alpha	Homo sapiens	126-130
23615261-4	2013	In this study, we investigated the effect of sulforaphane on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells.	Tetradecanoylphorbol Acetate	100-103	matrix metallopeptidase 9	Homo sapiens	113-118
23615261-5	2013	TPA-induced MMP-9 expression and cell invasion were decreased by sulforaphane treatment.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	12-17
23615261-9	2013	In this study, we demonstrated that the inhibition of TPA-induced MMP-9 expression and cell invasion by sulforaphane was mediated by the suppression of the NF-kappaB pathway in MCF-7 cells.	Tetradecanoylphorbol Acetate	54-57	matrix metallopeptidase 9	Homo sapiens	66-71
21089054-0	2011	Acteoside inhibits PMA-induced matrix metalloproteinase-9 expression via CaMK/ERK- and JNK/NF-kappaB-dependent signaling.	Tetradecanoylphorbol Acetate	19-22	matrix metallopeptidase 9	Homo sapiens	31-57
21089054-5	2011	We found that acteoside suppresses phorbol-12-myristate-13-acetate (PMA)-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB activation.	Tetradecanoylphorbol Acetate	35-66	matrix metallopeptidase 9	Homo sapiens	82-108
21089054-5	2011	We found that acteoside suppresses phorbol-12-myristate-13-acetate (PMA)-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB activation.	Tetradecanoylphorbol Acetate	35-66	matrix metallopeptidase 9	Homo sapiens	110-115
21089054-5	2011	We found that acteoside suppresses phorbol-12-myristate-13-acetate (PMA)-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB activation.	Tetradecanoylphorbol Acetate	68-71	matrix metallopeptidase 9	Homo sapiens	82-108
23353996-3	2013	Our results revealed that the levels             of MMP-9 mRNA and protein expression were significantly increased by TPA but not             MMP-2 in TPC-1 and MCF7 cells.	Tetradecanoylphorbol Acetate	118-121	matrix metallopeptidase 9	Homo sapiens	52-57
8392354-2	1993	Treatment of WEHI-3B cells with 200 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) for 5 min leads to the activation of cytosolic DGK without significant effect on microsomal DGK.	Tetradecanoylphorbol Acetate	39-75	diacylglycerol kinase, beta	Mus musculus	129-132
23353996-4	2013	To verify the regulatory mechanism of TPA-induced             MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126,             and TPA-induced MMP-9 expression was significantly decreased.	Tetradecanoylphorbol Acetate	38-41	matrix metallopeptidase 9	Homo sapiens	62-67
23353996-4	2013	To verify the regulatory mechanism of TPA-induced             MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126,             and TPA-induced MMP-9 expression was significantly decreased.	Tetradecanoylphorbol Acetate	38-41	matrix metallopeptidase 9	Homo sapiens	174-179
23353996-4	2013	To verify the regulatory mechanism of TPA-induced             MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126,             and TPA-induced MMP-9 expression was significantly decreased.	Tetradecanoylphorbol Acetate	162-165	matrix metallopeptidase 9	Homo sapiens	62-67
23490067-7	2013	AA clearly increased TPA-induced HL-60 cell differentiation, as evidenced by a marked increase in CD11b expression, which was inhibited by NAC and PD98059 addition.	Tetradecanoylphorbol Acetate	21-24	integrin subunit alpha M	Homo sapiens	98-103
23292685-0	2013	Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition             of NF-kappaB-dependent MMP-9 expression.	Tetradecanoylphorbol Acetate	15-18	matrix metallopeptidase 9	Homo sapiens	111-116
23292685-6	2013	In this study, we investigated             the inhibitory effect of sulfuretin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced             MMP-9 expression and cell invasion in MCF-7 cells.	Tetradecanoylphorbol Acetate	82-118	matrix metallopeptidase 9	Homo sapiens	145-150
23292685-6	2013	In this study, we investigated             the inhibitory effect of sulfuretin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced             MMP-9 expression and cell invasion in MCF-7 cells.	Tetradecanoylphorbol Acetate	120-123	matrix metallopeptidase 9	Homo sapiens	145-150
21372127-9	2011	Our data showed that phorbol 12-myristate 13-acetate-induced differentiation of macrophages is accompanied by a robust induction of apoE and STAT1 expression.	Tetradecanoylphorbol Acetate	21-52	signal transducer and activator of transcription 1	Homo sapiens	141-146
21295103-5	2011	The mechanism revealed that wogonin significantly inhibited the expression and activity of both endogenous and phorbol-12-myristate-13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) potentially associating with the suppression of translocation of protein kinase C (PKC) delta and phosphorylation of extracellular signal-regulated kinase (ERK1/2).	Tetradecanoylphorbol Acetate	111-142	matrix metallopeptidase 9	Homo sapiens	157-183
21295103-5	2011	The mechanism revealed that wogonin significantly inhibited the expression and activity of both endogenous and phorbol-12-myristate-13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) potentially associating with the suppression of translocation of protein kinase C (PKC) delta and phosphorylation of extracellular signal-regulated kinase (ERK1/2).	Tetradecanoylphorbol Acetate	111-142	matrix metallopeptidase 9	Homo sapiens	185-190
21295103-5	2011	The mechanism revealed that wogonin significantly inhibited the expression and activity of both endogenous and phorbol-12-myristate-13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) potentially associating with the suppression of translocation of protein kinase C (PKC) delta and phosphorylation of extracellular signal-regulated kinase (ERK1/2).	Tetradecanoylphorbol Acetate	144-147	matrix metallopeptidase 9	Homo sapiens	157-183
21295103-5	2011	The mechanism revealed that wogonin significantly inhibited the expression and activity of both endogenous and phorbol-12-myristate-13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) potentially associating with the suppression of translocation of protein kinase C (PKC) delta and phosphorylation of extracellular signal-regulated kinase (ERK1/2).	Tetradecanoylphorbol Acetate	144-147	matrix metallopeptidase 9	Homo sapiens	185-190
21346238-8	2011	Crossing IL-17A-deficient mice with K5.Stat3C mice resulted in partial attenuation of 12-O-tetradecanoylphorbol-13-acetate-induced lesions, which were further attenuated by anti-IL-12/23p40 Ab treatment.	Tetradecanoylphorbol Acetate	86-122	interleukin 17A	Mus musculus	9-15
23292685-8	2013	We demonstrated that             sulfuretin mediated the inhibition of TPA-induced MMP-9 expression and that cell             invasion in MCF-7 cells involved suppression of the NF-kappaB pathway.	Tetradecanoylphorbol Acetate	71-74	matrix metallopeptidase 9	Homo sapiens	83-88
23242121-2	2013	In this study, we investigated the inhibitory             effects of guggulsterone isomers (cis or trans) on 12-O-tetradecanoylpho-bol-13-acetate             (TPA)-induced MMP-9 expression.	Tetradecanoylphorbol Acetate	159-162	matrix metallopeptidase 9	Homo sapiens	172-177
8392354-2	1993	Treatment of WEHI-3B cells with 200 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) for 5 min leads to the activation of cytosolic DGK without significant effect on microsomal DGK.	Tetradecanoylphorbol Acetate	39-75	diacylglycerol kinase, beta	Mus musculus	174-177
23242121-4	2013	Cis-guggulsterone was             more potent than trans-guggulsterone in the inhibition of TPA-induced MMP-9 expression             and invasion of MCF-7 cells.	Tetradecanoylphorbol Acetate	92-95	matrix metallopeptidase 9	Homo sapiens	104-109
8392354-2	1993	Treatment of WEHI-3B cells with 200 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) for 5 min leads to the activation of cytosolic DGK without significant effect on microsomal DGK.	Tetradecanoylphorbol Acetate	77-80	diacylglycerol kinase, beta	Mus musculus	129-132
23440225-4	2013	The purpose of this study was to examine which PKC isoforms are responsible for the PMA-induced augmentation of long-term potentiation (LTP) in the CA1 stratum radiatum of the hippocampus in vitro and verify that this facilitation requires NMDAR activation.	Tetradecanoylphorbol Acetate	84-87	carbonic anhydrase 1	Homo sapiens	148-151
8392354-2	1993	Treatment of WEHI-3B cells with 200 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) for 5 min leads to the activation of cytosolic DGK without significant effect on microsomal DGK.	Tetradecanoylphorbol Acetate	77-80	diacylglycerol kinase, beta	Mus musculus	174-177
8392354-3	1993	When these cells were first exposed to 50 microM ET-16-OCH3-GPC for 30 min prior to activation with TPA, the activity of DGK was inhibited by about 70%, as measured by the ability of enzyme to form [32P]phosphatidic acid ([32P]PA).	Tetradecanoylphorbol Acetate	100-103	diacylglycerol kinase, beta	Mus musculus	121-124
8374508-6	1993	Vitamin E succinate plus suboptimal levels of the protein kinase C (PKC) activator phorbol myristate acetate (PMA) induced the highest levels of IL-2 by EL-4 cells.	Tetradecanoylphorbol Acetate	83-108	interleukin 2	Mus musculus	145-149
23293002-3	2013	In contrast, in T cells, BOB.1/OBF.1 expression is inducible by treatment of cells with PMA/Ionomycin or by antigen receptor engagement, indicating a marked difference in the regulation of BOB.1/OBF.1 expression in B versus T cells.	Tetradecanoylphorbol Acetate	88-91	POU class 2 homeobox associating factor 1	Homo sapiens	25-30
23293002-3	2013	In contrast, in T cells, BOB.1/OBF.1 expression is inducible by treatment of cells with PMA/Ionomycin or by antigen receptor engagement, indicating a marked difference in the regulation of BOB.1/OBF.1 expression in B versus T cells.	Tetradecanoylphorbol Acetate	88-91	POU class 2 homeobox associating factor 1	Homo sapiens	31-36
23293002-3	2013	In contrast, in T cells, BOB.1/OBF.1 expression is inducible by treatment of cells with PMA/Ionomycin or by antigen receptor engagement, indicating a marked difference in the regulation of BOB.1/OBF.1 expression in B versus T cells.	Tetradecanoylphorbol Acetate	88-91	POU class 2 homeobox associating factor 1	Homo sapiens	195-200
21314333-4	2011	The myeloperoxidase activity in TPA-treated skin from MSK1/2 knockout mice was significantly elevated compared with wild-type mice.	Tetradecanoylphorbol Acetate	32-35	myeloperoxidase	Mus musculus	4-19
21386996-5	2011	In agreement with previous studies, we demonstrated that PMA triggers a rapid ADAM17-mediated release of HB-EGF.	Tetradecanoylphorbol Acetate	57-60	ADAM metallopeptidase domain 17	Homo sapiens	78-84
8374508-6	1993	Vitamin E succinate plus suboptimal levels of the protein kinase C (PKC) activator phorbol myristate acetate (PMA) induced the highest levels of IL-2 by EL-4 cells.	Tetradecanoylphorbol Acetate	110-113	interleukin 2	Mus musculus	145-149
7678263-14	1993	Short-term treatment with PMA (1-2 h) again resulted in loss of the GM-CSF acidification response, but without a decrease in expression of high-affinity GM-CSF receptors.	Tetradecanoylphorbol Acetate	26-29	colony stimulating factor 2	Homo sapiens	68-74
21106746-5	2011	Site-directed mutagenesis studies indicate that both AP-1 response elements are critical for 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced MIEP activity in transient-transfection assays.	Tetradecanoylphorbol Acetate	93-129	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	53-57
23007964-5	2012	Cells were also treated with phorbol 12-myristate 13-acetate (PMA) to induce matrix metalloproteinase (MMP)-9 activity.	Tetradecanoylphorbol Acetate	29-60	matrix metallopeptidase 9	Homo sapiens	77-109
23007964-5	2012	Cells were also treated with phorbol 12-myristate 13-acetate (PMA) to induce matrix metalloproteinase (MMP)-9 activity.	Tetradecanoylphorbol Acetate	62-65	matrix metallopeptidase 9	Homo sapiens	77-109
8352883-1	1993	Treatment of the dorsal epidermis of SENCAR mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced a time- and dose-dependent stimulation of interleukin-1 alpha (IL-1 alpha) gene expression.	Tetradecanoylphorbol Acetate	54-90	interleukin 1 alpha	Mus musculus	147-166
21106746-5	2011	Site-directed mutagenesis studies indicate that both AP-1 response elements are critical for 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced MIEP activity in transient-transfection assays.	Tetradecanoylphorbol Acetate	131-134	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	53-57
8352883-1	1993	Treatment of the dorsal epidermis of SENCAR mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced a time- and dose-dependent stimulation of interleukin-1 alpha (IL-1 alpha) gene expression.	Tetradecanoylphorbol Acetate	54-90	interleukin 1 alpha	Mus musculus	168-178
21640608-1	2012	BACKGROUND: Patients who have ischemic strokes (ISs) while hospitalized for other conditions may be less likely to receive intravenous tissue plasminogen activator (IV tPA) when compared to patients who have strokes in the community.	Tetradecanoylphorbol Acetate	168-171	chromosome 20 open reading frame 181	Homo sapiens	135-163
22713854-3	2012	hCG or forskolin+PMA induced the transient increase in Runx1, Ptgs2, and Tnfaip6 expression, while the expression of Runx2 continued to increase until 48 h. The knockdown of the agonist-stimulated Runx2 expression increased Runx1, Ptgs2, and Tnfaip6 expression and PGE(2) levels in luteinizing granulosa cells.	Tetradecanoylphorbol Acetate	17-20	TNF alpha induced protein 6	Rattus norvegicus	73-80
22713854-3	2012	hCG or forskolin+PMA induced the transient increase in Runx1, Ptgs2, and Tnfaip6 expression, while the expression of Runx2 continued to increase until 48 h. The knockdown of the agonist-stimulated Runx2 expression increased Runx1, Ptgs2, and Tnfaip6 expression and PGE(2) levels in luteinizing granulosa cells.	Tetradecanoylphorbol Acetate	17-20	RUNX family transcription factor 1	Rattus norvegicus	224-229
22713854-3	2012	hCG or forskolin+PMA induced the transient increase in Runx1, Ptgs2, and Tnfaip6 expression, while the expression of Runx2 continued to increase until 48 h. The knockdown of the agonist-stimulated Runx2 expression increased Runx1, Ptgs2, and Tnfaip6 expression and PGE(2) levels in luteinizing granulosa cells.	Tetradecanoylphorbol Acetate	17-20	TNF alpha induced protein 6	Rattus norvegicus	242-249
8352883-1	1993	Treatment of the dorsal epidermis of SENCAR mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced a time- and dose-dependent stimulation of interleukin-1 alpha (IL-1 alpha) gene expression.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 alpha	Mus musculus	147-166
22773863-4	2012	TPA/IFN-gamma induced GSK-3 activation, which in turn activated signal transducer and activator of transcription 1.	Tetradecanoylphorbol Acetate	0-3	signal transducer and activator of transcription 1	Mus musculus	64-114
8352883-1	1993	Treatment of the dorsal epidermis of SENCAR mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced a time- and dose-dependent stimulation of interleukin-1 alpha (IL-1 alpha) gene expression.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 alpha	Mus musculus	168-178
8352883-2	1993	Levels of IL-1 alpha mRNA were elevated as early as 15 min and peaked at 3-4 h after a single application of TPA (2 micrograms or 10 micrograms).	Tetradecanoylphorbol Acetate	109-112	interleukin 1 alpha	Mus musculus	10-20
8352883-3	1993	IL-1 alpha gene expression increased in epidermal tissue isolated from SENCAR mice at 1, 3, 6, 10, 16, and 22 wk after a single treatment with 10 nmol 7,12-dimethylbenz[a]anthracene (DMBA) and subsequent twice-weekly application of 2 micrograms TPA.	Tetradecanoylphorbol Acetate	245-248	interleukin 1 alpha	Mus musculus	0-10
21865725-6	2011	We also found that celastrol inhibited PMA-induced MMP-9 expression at both the mRNA and the protein levels, and the proteolytic activity of MMP-9 in MCF-7 cells.	Tetradecanoylphorbol Acetate	39-42	matrix metallopeptidase 9	Homo sapiens	51-56
8352883-7	1993	Injection of IL-1 alpha-specific antibodies (50 micrograms) into SENCAR mice via the tail vein 2 h before treatment with TPA (2 micrograms or 10 micrograms) significantly (P &lt; 0.05) inhibited the skin thickening usually observed 24 h after treatment with TPA.	Tetradecanoylphorbol Acetate	121-124	interleukin 1 alpha	Mus musculus	13-23
22841871-3	2012	In this study, mechanisms of PBP-mediated antipromoting effects were investigated in a mouse model employing the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	128-164	phosphatidylethanolamine binding protein 1	Mus musculus	29-32
8352883-7	1993	Injection of IL-1 alpha-specific antibodies (50 micrograms) into SENCAR mice via the tail vein 2 h before treatment with TPA (2 micrograms or 10 micrograms) significantly (P &lt; 0.05) inhibited the skin thickening usually observed 24 h after treatment with TPA.	Tetradecanoylphorbol Acetate	258-261	interleukin 1 alpha	Mus musculus	13-23
22841871-3	2012	In this study, mechanisms of PBP-mediated antipromoting effects were investigated in a mouse model employing the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	166-169	phosphatidylethanolamine binding protein 1	Mus musculus	29-32
22841871-7	2012	Complementary confocal microscopic evaluation showed a decrease in TPA-induced PKCalpha fluorescence in PBP-3-pretreated membranes, whereas pretreatment with PBP-5 did not show a similar decrease.	Tetradecanoylphorbol Acetate	67-70	phosphatidylethanolamine binding protein 1	Mus musculus	104-107
8352883-10	1993	These data suggest that IL-1 alpha is a pivotal cytokine produced by specific subpopulations of epidermal keratinocytes and that IL-1 alpha primarily regulates the epidermal proliferative response of a distinctly separate population of keratinocytes after topical exposure of murine epidermis to TPA and secondarily modulates neutrophil migration into the dermis.	Tetradecanoylphorbol Acetate	296-299	interleukin 1 alpha	Mus musculus	129-139
22841871-8	2012	Based on the experiments with specific enzyme inhibitors and phosphospecific antibodies, both PBP-3 and PBP-5 were observed to decrease TPA-induced level and/or activity of phosphatidylinositol 3-kinase (PI3K) and AKT1 (pS473).	Tetradecanoylphorbol Acetate	136-139	phosphatidylethanolamine binding protein 1	Mus musculus	94-97
21625419-5	2011	Human brain microvascular endothelial cells were treated with a combination of phorbol 12-myristate 13-acetate (PMA), a carcinogen documented to increase MMP-9 and COX-2 through NF-kappaB, and several naturally occurring flavonoids.	Tetradecanoylphorbol Acetate	79-110	matrix metallopeptidase 9	Homo sapiens	154-159
22841871-8	2012	Based on the experiments with specific enzyme inhibitors and phosphospecific antibodies, both PBP-3 and PBP-5 were observed to decrease TPA-induced level and/or activity of phosphatidylinositol 3-kinase (PI3K) and AKT1 (pS473).	Tetradecanoylphorbol Acetate	136-139	phosphatidylethanolamine binding protein 1	Mus musculus	104-107
8352883-11	1993	Consequently, manipulation of IL-1 alpha may be a way to attenuate or abrogate the cutaneous response to TPA by altering keratinocyte proliferation, the resultant hyperplasia, and a portion of the inflammatory response characterized by dermal infiltration of neutrophils.	Tetradecanoylphorbol Acetate	105-108	interleukin 1 alpha	Mus musculus	30-40
22841871-10	2012	Altogether, PBP-mediated decrease in TPA-induced PKC phosphorylation correlated well with decreased TPA-induced NF-kappaB phosphorylation and downstream target proteins associated with proliferation, apoptosis, and inflammation in mouse skin.	Tetradecanoylphorbol Acetate	37-40	phosphatidylethanolamine binding protein 1	Mus musculus	12-15
8289985-4	1993	Calcitriol therapy resulted in significant increases in the phorbol myristate acetate (PMA)-induced secretion of IL-1 and IL-6 (p = 0.04 and 0.03, respectively).	Tetradecanoylphorbol Acetate	60-85	interleukin 1 alpha	Homo sapiens	113-117
22841871-10	2012	Altogether, PBP-mediated decrease in TPA-induced PKC phosphorylation correlated well with decreased TPA-induced NF-kappaB phosphorylation and downstream target proteins associated with proliferation, apoptosis, and inflammation in mouse skin.	Tetradecanoylphorbol Acetate	100-103	phosphatidylethanolamine binding protein 1	Mus musculus	12-15
20967886-3	2011	Mass spectrometry and Western blot analysis using phospho-specific antibodies revealed that phorbol 12-myristate 13-acetate (PMA) treatment induced the phosphorylation of synaptosomal-associated protein of 23 kDa (SNAP-23) on Ser(95), Ser(120), and Ser(160) in cultured astrocytes and C6 cells.	Tetradecanoylphorbol Acetate	92-123	synaptosome associated protein 23	Homo sapiens	171-212
20967886-3	2011	Mass spectrometry and Western blot analysis using phospho-specific antibodies revealed that phorbol 12-myristate 13-acetate (PMA) treatment induced the phosphorylation of synaptosomal-associated protein of 23 kDa (SNAP-23) on Ser(95), Ser(120), and Ser(160) in cultured astrocytes and C6 cells.	Tetradecanoylphorbol Acetate	92-123	synaptosome associated protein 23	Homo sapiens	214-221
20967886-3	2011	Mass spectrometry and Western blot analysis using phospho-specific antibodies revealed that phorbol 12-myristate 13-acetate (PMA) treatment induced the phosphorylation of synaptosomal-associated protein of 23 kDa (SNAP-23) on Ser(95), Ser(120), and Ser(160) in cultured astrocytes and C6 cells.	Tetradecanoylphorbol Acetate	125-128	synaptosome associated protein 23	Homo sapiens	171-212
20967886-3	2011	Mass spectrometry and Western blot analysis using phospho-specific antibodies revealed that phorbol 12-myristate 13-acetate (PMA) treatment induced the phosphorylation of synaptosomal-associated protein of 23 kDa (SNAP-23) on Ser(95), Ser(120), and Ser(160) in cultured astrocytes and C6 cells.	Tetradecanoylphorbol Acetate	125-128	synaptosome associated protein 23	Homo sapiens	214-221
22921746-4	2012	In this study, we investigated the inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion and the molecular mechanisms involved in MCF-7 cells.	Tetradecanoylphorbol Acetate	68-104	matrix metallopeptidase 9	Homo sapiens	119-124
22921746-4	2012	In this study, we investigated the inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion and the molecular mechanisms involved in MCF-7 cells.	Tetradecanoylphorbol Acetate	106-109	matrix metallopeptidase 9	Homo sapiens	119-124
22921746-5	2012	Our results showed that curcumin inhibits TPA-induced MMP-9 expression and cell invasion through suppressing NF-kappaB and AP-1 activation.	Tetradecanoylphorbol Acetate	42-45	matrix metallopeptidase 9	Homo sapiens	54-59
22921746-7	2012	These results indicate that curcumin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKCalpha, MAPK and NF-kappaB/AP-1 pathway in MCF-7 cells.	Tetradecanoylphorbol Acetate	60-63	matrix metallopeptidase 9	Homo sapiens	72-77
8289985-4	1993	Calcitriol therapy resulted in significant increases in the phorbol myristate acetate (PMA)-induced secretion of IL-1 and IL-6 (p = 0.04 and 0.03, respectively).	Tetradecanoylphorbol Acetate	87-90	interleukin 1 alpha	Homo sapiens	113-117
22623726-7	2012	The HECT E3 ubiquitin ligase smad ubiquitination regulatory factor-2 (Smurf2) was found to be recruited to connexin43 gap junctions in response to TPA treatment.	Tetradecanoylphorbol Acetate	147-150	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	29-68
1450403-4	1992	We showed that IL-4R mRNA accumulation in human T cells is enhanced fourfold after activation of different secondary signaling pathways by concanavalin A (Con A), phorbol myristate acetate (PMA), the calcium ionophore A23187, and combinations of these factors.	Tetradecanoylphorbol Acetate	163-188	interleukin 4 receptor	Homo sapiens	15-20
22623726-7	2012	The HECT E3 ubiquitin ligase smad ubiquitination regulatory factor-2 (Smurf2) was found to be recruited to connexin43 gap junctions in response to TPA treatment.	Tetradecanoylphorbol Acetate	147-150	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	70-76
22617836-7	2012	TPA-/CCK-stimulated Yes activation was completely inhibited by thapsigargin and the PKC inhibitor, GF109203X.	Tetradecanoylphorbol Acetate	0-3	cholecystokinin	Rattus norvegicus	5-8
22617836-8	2012	CCK/TPA stimulated the association of Yes with focal adhesion kinases (Pyk2, FAK) and its autophosphorylated forms (pY397FAK, pY402Pyk2).	Tetradecanoylphorbol Acetate	4-7	cholecystokinin	Rattus norvegicus	0-3
22617836-9	2012	Moreover, CCK/TPA stimulated Yes interacted with a number of other signaling proteins, including Shc, PKD, p130(Cas), PI3K and PTEN.	Tetradecanoylphorbol Acetate	14-17	cholecystokinin	Rattus norvegicus	10-13
22617836-9	2012	Moreover, CCK/TPA stimulated Yes interacted with a number of other signaling proteins, including Shc, PKD, p130(Cas), PI3K and PTEN.	Tetradecanoylphorbol Acetate	14-17	phosphatase and tensin homolog	Rattus norvegicus	127-131
22773582-0	2012	Sorafenib inhibits TPA-induced MMP-9 and VEGF expression via suppression of ERK/NF-kappaB pathway in hepatocellular carcinoma cells.	Tetradecanoylphorbol Acetate	19-22	matrix metallopeptidase 9	Homo sapiens	31-36
22773582-4	2012	TPA increased the NF-kappaB activity and the expressions of MMP-9 and VEGF significantly, but its effects were suppressed by sorafenib in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	60-65
22773582-6	2012	Furthermore, transfection of Huh7 cell with an inhibitor of kappaB-alpha mutant vector, led to reduced TPA-induced MMP-9 and VEGF mRNA expressions.	Tetradecanoylphorbol Acetate	103-106	matrix metallopeptidase 9	Homo sapiens	115-120
22773582-7	2012	Sorafenib inhibits TPA-induced MMP-9 and VEGF expressions via the suppression of ERK/NF-kappaB pathway in HCC cells.	Tetradecanoylphorbol Acetate	19-22	matrix metallopeptidase 9	Homo sapiens	31-36
22505246-5	2012	Juglone significantly suppressed TPA-induced protein kinase B (AKT) and c-Jun phosphorylation and c-fos activation, but not mitogen-activated protein-kinase kinase (MEK), extracellular signaling-regulated kinase (ERK) or 90 kDa ribosomal protein S6 kinase (RSK) phosphorylation.	Tetradecanoylphorbol Acetate	33-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-77
22589261-11	2012	PBMC stimulated with PMA/ionomycin expressed higher levels of IL-22 in patients with RA than controls but this was not significant (mean 584.75 pg/ml and 295.57 pg/ml; p = 0.553).	Tetradecanoylphorbol Acetate	21-24	interleukin 22	Homo sapiens	62-67
22561169-6	2012	A reporter gene assay revealed that Mn2+ promoted the activity of AP-1 (activator protein-1, a complex of c-Fos and c-Jun) in the presence of PMA.	Tetradecanoylphorbol Acetate	142-145	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-70
22561169-6	2012	A reporter gene assay revealed that Mn2+ promoted the activity of AP-1 (activator protein-1, a complex of c-Fos and c-Jun) in the presence of PMA.	Tetradecanoylphorbol Acetate	142-145	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-91
22561169-6	2012	A reporter gene assay revealed that Mn2+ promoted the activity of AP-1 (activator protein-1, a complex of c-Fos and c-Jun) in the presence of PMA.	Tetradecanoylphorbol Acetate	142-145	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-111
22561169-6	2012	A reporter gene assay revealed that Mn2+ promoted the activity of AP-1 (activator protein-1, a complex of c-Fos and c-Jun) in the presence of PMA.	Tetradecanoylphorbol Acetate	142-145	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-121
22561169-8	2012	These results suggest that Mn2+ promotes PMA-induced IL-2 production by inducing the production and activation of AP-1, at least in part.	Tetradecanoylphorbol Acetate	41-44	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	114-118
22160839-4	2012	Th1 and Th2 cells, levels of INF-gamma, IL-2, IL-4 and the activities of T-bet and GATA3 were significantly increased after incubation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	140-143	negative elongation factor complex member C/D	Homo sapiens	0-3
22160839-4	2012	Th1 and Th2 cells, levels of INF-gamma, IL-2, IL-4 and the activities of T-bet and GATA3 were significantly increased after incubation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	140-143	GATA binding protein 3	Homo sapiens	83-88
22160839-5	2012	However, the number of Th1 cells, Th1/ Th2, the levels of INF-gamma and INF-gamma/IL-4, and the activities and protein levels of T-bet and GATA3 were decreased after incubation with PMA and ionomycin in the presence of morphine.	Tetradecanoylphorbol Acetate	182-185	negative elongation factor complex member C/D	Homo sapiens	23-26
22160839-5	2012	However, the number of Th1 cells, Th1/ Th2, the levels of INF-gamma and INF-gamma/IL-4, and the activities and protein levels of T-bet and GATA3 were decreased after incubation with PMA and ionomycin in the presence of morphine.	Tetradecanoylphorbol Acetate	182-185	negative elongation factor complex member C/D	Homo sapiens	34-37
22160839-5	2012	However, the number of Th1 cells, Th1/ Th2, the levels of INF-gamma and INF-gamma/IL-4, and the activities and protein levels of T-bet and GATA3 were decreased after incubation with PMA and ionomycin in the presence of morphine.	Tetradecanoylphorbol Acetate	182-185	GATA binding protein 3	Homo sapiens	139-144
22464766-11	2012	Finally, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced CD200R(+) infiltrative cells and epidermal proliferation were suppressed in Invalpha6beta4 mice treated with M-CSF neutralizing antibodies.	Tetradecanoylphorbol Acetate	9-45	CD200 receptor 1	Mus musculus	60-66
22464766-11	2012	Finally, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced CD200R(+) infiltrative cells and epidermal proliferation were suppressed in Invalpha6beta4 mice treated with M-CSF neutralizing antibodies.	Tetradecanoylphorbol Acetate	9-45	colony stimulating factor 1 (macrophage)	Mus musculus	169-174
22464766-11	2012	Finally, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced CD200R(+) infiltrative cells and epidermal proliferation were suppressed in Invalpha6beta4 mice treated with M-CSF neutralizing antibodies.	Tetradecanoylphorbol Acetate	47-50	CD200 receptor 1	Mus musculus	60-66
22464766-11	2012	Finally, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced CD200R(+) infiltrative cells and epidermal proliferation were suppressed in Invalpha6beta4 mice treated with M-CSF neutralizing antibodies.	Tetradecanoylphorbol Acetate	47-50	colony stimulating factor 1 (macrophage)	Mus musculus	169-174
22297135-4	2012	Both vMIP-I and the vMIP-II gene products were detected 24 h post-induction with 12-O-tetradecanoylphorbol-13-acetate until 60 h in the cytoplasm of primary effusion lymphoma cell lines.	Tetradecanoylphorbol Acetate	81-117	K6	Human gammaherpesvirus 8	5-11
22151918-7	2012	RESULTS:   Cucurbitacin B has significantly suppressed 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cell invasion and migration in a concentration-dependent manner, which was accompanied with suppression of TPA-induced MMP-9 expression through inactivation of phosphorylation of extracellular signal-regulated kinase (ERK) 1/2, p38 and Akt.	Tetradecanoylphorbol Acetate	93-96	matrix metallopeptidase 9	Homo sapiens	225-230
22151918-8	2012	In the nucleus, it has also strongly suppressed TPA-stimulated expression of NF-kappaB, c-Jun and c-Fos.	Tetradecanoylphorbol Acetate	48-51	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	88-93
22151918-8	2012	In the nucleus, it has also strongly suppressed TPA-stimulated expression of NF-kappaB, c-Jun and c-Fos.	Tetradecanoylphorbol Acetate	48-51	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-103
22543148-5	2012	RESULTS: After stimulation with different concentrations of glucose (5.6 and 16.7 mmol/L), HCNP group showed significantly higher insulin levels than the control and HCNP+ PMA groups.	Tetradecanoylphorbol Acetate	172-175	phosphatidylethanolamine binding protein 1	Rattus norvegicus	91-95
22336225-4	2012	Other indicators of PMA-induced HEL cell differentiation, such as increased expression of CD41/CD61 and an increase in cell complexity/granularity, were inhibited by cicaprost in an IP receptor-dependent and STAT3-dependent manner.	Tetradecanoylphorbol Acetate	20-23	integrin subunit alpha 2b	Homo sapiens	90-94
22052014-10	2012	Consistent with these data, PMA-induced Egr-1 interaction with the NHE2 promoter region was prevented in nuclear extracts from U0126-pretreated cells.	Tetradecanoylphorbol Acetate	28-31	solute carrier family 9 member A2	Homo sapiens	67-71
22023041-7	2012	By linear correlation analysis, GDF-15 exhibited a moderate relation to von Willebrand factor (r = 0.30), and weak, albeit significant relations (r = 0.13-0.29) to E-selectin, P-selectin, ICAM-1, VCAM-1, MMP-9, TIMP-1, D-dimer, PAI-1 activity and tPA-antigen.	Tetradecanoylphorbol Acetate	247-250	growth differentiation factor 15	Homo sapiens	32-38
22206674-0	2012	PMA induces GCMa phosphorylation and alters its stability via the PKC- and ERK-dependent pathway.	Tetradecanoylphorbol Acetate	0-3	glial cells missing transcription factor 1	Homo sapiens	12-16
22206674-5	2012	PMA caused a transient decrease in the endogenous GCMa protein level in JEG-3 cells that was accompanied by an increase in GCMa phosphorylation.	Tetradecanoylphorbol Acetate	0-3	glial cells missing transcription factor 1	Homo sapiens	50-54
22206674-5	2012	PMA caused a transient decrease in the endogenous GCMa protein level in JEG-3 cells that was accompanied by an increase in GCMa phosphorylation.	Tetradecanoylphorbol Acetate	0-3	glial cells missing transcription factor 1	Homo sapiens	123-127
23258984-6	2012	TGSs and individual GSs also significantly decreased MMP-2 and MMP-9 reporter gene activities in the presence of phorbol 12-myristate 13-acetate (PMA), the MMP inducer.	Tetradecanoylphorbol Acetate	113-144	matrix metallopeptidase 2	Mus musculus	53-58
23258984-6	2012	TGSs and individual GSs also significantly decreased MMP-2 and MMP-9 reporter gene activities in the presence of phorbol 12-myristate 13-acetate (PMA), the MMP inducer.	Tetradecanoylphorbol Acetate	146-149	matrix metallopeptidase 2	Mus musculus	53-58
22312276-3	2012	The present study investigates the effects of aqueous extracts of those plants on the production of reactive oxygen species (ROS) and the release of myeloperoxidase (MPO) by equine neutrophils activated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	208-239	myeloperoxidase	Equus caballus	149-164
22312276-3	2012	The present study investigates the effects of aqueous extracts of those plants on the production of reactive oxygen species (ROS) and the release of myeloperoxidase (MPO) by equine neutrophils activated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	208-239	myeloperoxidase	Equus caballus	166-169
22312276-3	2012	The present study investigates the effects of aqueous extracts of those plants on the production of reactive oxygen species (ROS) and the release of myeloperoxidase (MPO) by equine neutrophils activated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	241-244	myeloperoxidase	Equus caballus	166-169
21947138-7	2012	In both cell lines, zymography demonstrated a band             corresponding to MMP-2 in normal cells and MMP-9 with phorbol 12-myristate 13-acetate             treatment.	Tetradecanoylphorbol Acetate	117-148	matrix metallopeptidase 9	Homo sapiens	106-111
23056582-3	2012	Phosphorylation at Thr 163 in the PEST region, stimulated by 12-O-tetradecanoylphorbol acetic acid (TPA)-induced activation of extracellular signal-regulated kinase (ERK), is associated with Mcl-1 stabilization in BL41-3 Burkitt lymphoma cells.	Tetradecanoylphorbol Acetate	100-103	induced myeloid leukemia cell differentiation protein Mcl-1	Cricetulus griseus	191-196
23056582-7	2012	TPA-treated BL41-3 cells, in addition to exhibiting Thr 163 phosphorylation and Mcl-1 stabilization, exhibited an ~10-fold increase in resistance to multiple chemotherapeutic agents, including Ara-C, etoposide, vinblastine, or cisplatin.	Tetradecanoylphorbol Acetate	0-3	induced myeloid leukemia cell differentiation protein Mcl-1	Cricetulus griseus	80-85
22299029-0	2012	Differential role of PKC-induced c-Jun in HTLV-1 LTR activation by 12-O-tetradecanoylphorbol-13-acetate in different human T-cell lines.	Tetradecanoylphorbol Acetate	67-103	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	33-38
22253701-10	2012	TPA-induced activity of pBL-FFL-CAT5 was negatively regulated by T3/TR.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 25 member 5	Homo sapiens	65-70
21989206-8	2011	KEY FINDINGS: Transduced PEP-1-CypA protein markedly inhibited lipopolysaccharide- and 12-O-tetradecanoyl phorbol-13-acetate-induced expression levels of COX-2 as well as pro-inflammatory cytokine levels in vitro and in vivo.	Tetradecanoylphorbol Acetate	87-124	peptidylprolyl isomerase A	Mus musculus	31-35
21864583-3	2011	In this study, we examined the functional roles of mouse Zac1 (mZac1) in HeLa cells treated with 12-O-tetradecanoylphorbol-13-acetate (PMA), a potent Activator protein 1 (AP-1) activator.	Tetradecanoylphorbol Acetate	97-133	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	150-169
21864583-3	2011	In this study, we examined the functional roles of mouse Zac1 (mZac1) in HeLa cells treated with 12-O-tetradecanoylphorbol-13-acetate (PMA), a potent Activator protein 1 (AP-1) activator.	Tetradecanoylphorbol Acetate	97-133	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	171-175
21864583-3	2011	In this study, we examined the functional roles of mouse Zac1 (mZac1) in HeLa cells treated with 12-O-tetradecanoylphorbol-13-acetate (PMA), a potent Activator protein 1 (AP-1) activator.	Tetradecanoylphorbol Acetate	135-138	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	150-169
21864583-3	2011	In this study, we examined the functional roles of mouse Zac1 (mZac1) in HeLa cells treated with 12-O-tetradecanoylphorbol-13-acetate (PMA), a potent Activator protein 1 (AP-1) activator.	Tetradecanoylphorbol Acetate	135-138	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	171-175
22232712-0	2011	The Effect of Doxycycline on PMA-Induced MUC5B Expression via MMP-9 and p38 in NCI-H292 Cells.	Tetradecanoylphorbol Acetate	29-32	matrix metallopeptidase 9	Homo sapiens	62-67
22232712-5	2011	Therefore, the effects and signal pathways of doxycycline on PMA-induced MUC5B expression dependent MMP-9 in human airway epithelial cells were investigated.	Tetradecanoylphorbol Acetate	61-64	matrix metallopeptidase 9	Homo sapiens	100-105
22232712-6	2011	METHODS: In human NCI-H292 airway epithelial cells, MUC5B and MMP-9 mRNA expression, MUC5B protein expression, and MMP-9 protein activity after the treatment with PMA, MMP-9 or doxycycline were determined by reverse transcriptase-polymerase chain reaction, enzyme immunoassay, gelatin zymography, and Western blot analysis.	Tetradecanoylphorbol Acetate	163-166	matrix metallopeptidase 9	Homo sapiens	62-67
22232712-9	2011	Doxycycline inhibited PMA-induced MUC5B expression, and PMA-induced MMP-9 mRNA expression and protein activity.	Tetradecanoylphorbol Acetate	56-59	matrix metallopeptidase 9	Homo sapiens	68-73
22232712-11	2011	CONCLUSION: The results of this study suggest that doxycycline inhibited PMA-induced MUC5B mRNA expression and protein production through the MMP-9 and p38 pathways in human NCI-H292 airway epithelial cells.	Tetradecanoylphorbol Acetate	73-76	matrix metallopeptidase 9	Homo sapiens	142-147
22217709-7	2011	Zymography revealed matrix MMP-2 and phorbol 12-myristate 13-acetate induced MMP-9 expression.	Tetradecanoylphorbol Acetate	37-68	matrix metallopeptidase 9	Homo sapiens	77-82
21720768-5	2011	However, when HL-60 and NB4 were differentiated to monocytic lineage induced by phorbol 12-myristate 13-acetate the expressions of beta3GnT-2 and beta3GnT-8 showed no alterations or the increase of expressions was far less than those in myelocytic differentiation.	Tetradecanoylphorbol Acetate	80-111	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	131-141
21720768-5	2011	However, when HL-60 and NB4 were differentiated to monocytic lineage induced by phorbol 12-myristate 13-acetate the expressions of beta3GnT-2 and beta3GnT-8 showed no alterations or the increase of expressions was far less than those in myelocytic differentiation.	Tetradecanoylphorbol Acetate	80-111	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	Homo sapiens	146-156
21720768-6	2011	By means of FITC-labeled tomato lectin affinity staining and flow-cytometry, it was found that the product of beta3GnT-2 and -8, polyLacNAc was also increased on the cell surface of HL-60 and NB4 treated with ATRA or DMSO, but unchanged when treated with PMA.	Tetradecanoylphorbol Acetate	255-258	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	110-120
22192260-5	2011	In the presence of phorbol-12-myristate-13-acetate-ionomycin, with or without CAPE treatment, the asthmatic children showed significantly decreased levels of IL-10 secretion compared with the healthy controls.	Tetradecanoylphorbol Acetate	19-50	interleukin 10	Homo sapiens	158-163
21925496-3	2011	The present study aimed to investigate the modulating effects of cilostazol on monocyte invasion and the gene expressions of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1.	Tetradecanoylphorbol Acetate	223-254	matrix metallopeptidase 9	Homo sapiens	125-151
21925496-3	2011	The present study aimed to investigate the modulating effects of cilostazol on monocyte invasion and the gene expressions of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1.	Tetradecanoylphorbol Acetate	256-259	matrix metallopeptidase 9	Homo sapiens	125-151
21959183-5	2011	In addition, the TPA-induced increase in myeloperoxidase activity (MPO) in the ear was reduced (77 +- 8%) by the topical application of EEVS.	Tetradecanoylphorbol Acetate	17-20	myeloperoxidase	Mus musculus	41-56
21959183-5	2011	In addition, the TPA-induced increase in myeloperoxidase activity (MPO) in the ear was reduced (77 +- 8%) by the topical application of EEVS.	Tetradecanoylphorbol Acetate	17-20	myeloperoxidase	Mus musculus	67-70
21803046-10	2011	Whereas TMX-induced PKC activation was not attenuated inhibition of PKCbeta, inhibition of PKCalpha with HBDDE prevented inhibitory effects of both PMA and TMX.	Tetradecanoylphorbol Acetate	148-151	protein kinase C, alpha	Rattus norvegicus	91-99
21896870-8	2011	In contrast, PMA, a potent PKC activator, partially abolished the positive effect of ET on the axonal regeneration of axotomized RGCs.	Tetradecanoylphorbol Acetate	13-16	protein kinase C, gamma	Rattus norvegicus	27-30
21699843-7	2011	RESULTS: The PKC activator phorbol 12-myristate 13-acetate (PMA) decreased I(Ks) density by &gt;60% (P &lt; .05) when coexpressed with wild-type dynamin 2 in CHO cells, but had no effect when coexpressed with K44A-dynamin 2.	Tetradecanoylphorbol Acetate	27-58	dynamin-2	Cricetulus griseus	145-154
21699843-7	2011	RESULTS: The PKC activator phorbol 12-myristate 13-acetate (PMA) decreased I(Ks) density by &gt;60% (P &lt; .05) when coexpressed with wild-type dynamin 2 in CHO cells, but had no effect when coexpressed with K44A-dynamin 2.	Tetradecanoylphorbol Acetate	27-58	dynamin-2	Cricetulus griseus	214-223
21699843-7	2011	RESULTS: The PKC activator phorbol 12-myristate 13-acetate (PMA) decreased I(Ks) density by &gt;60% (P &lt; .05) when coexpressed with wild-type dynamin 2 in CHO cells, but had no effect when coexpressed with K44A-dynamin 2.	Tetradecanoylphorbol Acetate	60-63	dynamin-2	Cricetulus griseus	145-154
21699843-7	2011	RESULTS: The PKC activator phorbol 12-myristate 13-acetate (PMA) decreased I(Ks) density by &gt;60% (P &lt; .05) when coexpressed with wild-type dynamin 2 in CHO cells, but had no effect when coexpressed with K44A-dynamin 2.	Tetradecanoylphorbol Acetate	60-63	dynamin-2	Cricetulus griseus	214-223
21805048-7	2011	Results showed that the expression of MMP-9 and cell invasion in response to TPA was increased, whereas TPA-induced MMP-9 expression and cell invasion was decreased by RCE.	Tetradecanoylphorbol Acetate	77-80	matrix metallopeptidase 9	Homo sapiens	38-43
21336564-4	2011	Rapamycin potentiated differentiation of ATRA-treated NB4 cells, but the combination of rapamycin and LY 294002 inhibited the expression of CD11b in both ATRA- and phorbol myristate acetate (PMA)-stimulated cells more than PI3K inhibitor alone.	Tetradecanoylphorbol Acetate	164-189	integrin subunit alpha M	Homo sapiens	140-145
21336564-4	2011	Rapamycin potentiated differentiation of ATRA-treated NB4 cells, but the combination of rapamycin and LY 294002 inhibited the expression of CD11b in both ATRA- and phorbol myristate acetate (PMA)-stimulated cells more than PI3K inhibitor alone.	Tetradecanoylphorbol Acetate	191-194	integrin subunit alpha M	Homo sapiens	140-145
21737808-1	2011	BACKGROUND AND PURPOSE: Plasma matrix metalloproteinase-9 levels predict posttissue plasminogen activator (tPA) hemorrhage.	Tetradecanoylphorbol Acetate	107-110	matrix metallopeptidase 9	Homo sapiens	31-57
21737808-3	2011	RESULTS: Matrix metalloproteinase-9 level decreased at 72 hours compared with baseline in MINOS (tPA, P=0.0022; non-tPA, P=0.0066) and was lower than in the non-MINOS comparison group at 24 hours (tPA, P&lt;0.0001; non-tPA, P=0.0019).	Tetradecanoylphorbol Acetate	97-100	matrix metallopeptidase 9	Homo sapiens	9-35
21737808-3	2011	RESULTS: Matrix metalloproteinase-9 level decreased at 72 hours compared with baseline in MINOS (tPA, P=0.0022; non-tPA, P=0.0066) and was lower than in the non-MINOS comparison group at 24 hours (tPA, P&lt;0.0001; non-tPA, P=0.0019).	Tetradecanoylphorbol Acetate	116-119	matrix metallopeptidase 9	Homo sapiens	9-35
21737808-3	2011	RESULTS: Matrix metalloproteinase-9 level decreased at 72 hours compared with baseline in MINOS (tPA, P=0.0022; non-tPA, P=0.0066) and was lower than in the non-MINOS comparison group at 24 hours (tPA, P&lt;0.0001; non-tPA, P=0.0019).	Tetradecanoylphorbol Acetate	116-119	matrix metallopeptidase 9	Homo sapiens	9-35
21737808-3	2011	RESULTS: Matrix metalloproteinase-9 level decreased at 72 hours compared with baseline in MINOS (tPA, P=0.0022; non-tPA, P=0.0066) and was lower than in the non-MINOS comparison group at 24 hours (tPA, P&lt;0.0001; non-tPA, P=0.0019).	Tetradecanoylphorbol Acetate	116-119	matrix metallopeptidase 9	Homo sapiens	9-35
21737808-4	2011	CONCLUSIONS: Lower plasma matrix metalloproteinase-9 was seen among tPA-treated subjects in the MINOS trial.	Tetradecanoylphorbol Acetate	68-71	matrix metallopeptidase 9	Homo sapiens	26-52
21737808-5	2011	Combining minocycline with tPA may prevent the adverse consequences of thrombolytic therapy through suppression of matrix metalloproteinase-9 activity.	Tetradecanoylphorbol Acetate	27-30	matrix metallopeptidase 9	Homo sapiens	115-141
21784979-8	2011	Impaired TetON-HIF-1:VEGF(Delta) neovascularization could be partially rescued by 12-O-tetradecanoylphorbol-13-acetate skin treatment.	Tetradecanoylphorbol Acetate	82-118	vascular endothelial growth factor A	Mus musculus	21-25
21665893-3	2011	We now provide experimental evidence to indicate that protein kinase D (PKD) promotes survival signals in LNCaP cells in response to PMA treatment.	Tetradecanoylphorbol Acetate	133-136	protein kinase D1	Homo sapiens	54-70
21665893-3	2011	We now provide experimental evidence to indicate that protein kinase D (PKD) promotes survival signals in LNCaP cells in response to PMA treatment.	Tetradecanoylphorbol Acetate	133-136	protein kinase D1	Homo sapiens	72-75
21306750-7	2011	Insulin secretion induced by the protein kinase A (PKA) activators forskolin and 3-isobutyl-1-methyl-xanthine, in the presence of 11.1 mmol/L glucose, was lower in LDLR(-/-) islets and was normalized in the presence of the protein kinase C pathway activators carbachol and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	273-304	low density lipoprotein receptor	Mus musculus	164-168
21713380-0	2011	Inhibitory effect of phytoglycoprotein (38 kDa) on expression of matrix metalloproteinase-9 in 12-O-tetradecanoylphorbol-13-acetate-treated HepG2cells.	Tetradecanoylphorbol Acetate	95-131	matrix metallopeptidase 9	Homo sapiens	65-91
20889800-6	2011	We demonstrate that IL-10 can regulate this protective phenotype in phorbol myristate acetate (PMA)-treated THP-1 cells, monocyte-derived macrophages (MDMs), and human alveolar macrophages (AMs) infected with Mtb.	Tetradecanoylphorbol Acetate	68-93	interleukin 10	Homo sapiens	20-25
20889800-6	2011	We demonstrate that IL-10 can regulate this protective phenotype in phorbol myristate acetate (PMA)-treated THP-1 cells, monocyte-derived macrophages (MDMs), and human alveolar macrophages (AMs) infected with Mtb.	Tetradecanoylphorbol Acetate	95-98	interleukin 10	Homo sapiens	20-25
21045076-10	2011	Inhibition of SOD2 reduced the PMA-induced respiratory burst and IL1A, IL-1R1, IL-1R2 and IL8RA gene expression in neutrophil-differentiated HL60 cells.	Tetradecanoylphorbol Acetate	31-34	C-X-C motif chemokine receptor 1	Homo sapiens	90-95
21448567-6	2011	Simvastatin and atorvastatin, but not pravastatin, attenuated PMA-induced increases in MMP-9 levels (P &lt; 0.05).	Tetradecanoylphorbol Acetate	62-65	matrix metallopeptidase 9	Homo sapiens	87-92
21707856-5	2011	And increased phosphorylation of XIAP at the site was also confirmed in SH-SY5Y cells treated with PKC activator, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	114-145	X-linked inhibitor of apoptosis	Homo sapiens	33-37
21707856-5	2011	And increased phosphorylation of XIAP at the site was also confirmed in SH-SY5Y cells treated with PKC activator, phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	147-150	X-linked inhibitor of apoptosis	Homo sapiens	33-37
21707856-8	2011	RESULTS: Recombinant XIAP was phosphorylated at Ser(87) by PKC in vitro and treatment of XIAP-transfected SH-SY5Y cells with a PKC activator, phorbol 12-myristate 13-acetate (PMA) induced phosphorylation of XIAP at Ser(87) .	Tetradecanoylphorbol Acetate	142-173	X-linked inhibitor of apoptosis	Homo sapiens	21-25
21707856-8	2011	RESULTS: Recombinant XIAP was phosphorylated at Ser(87) by PKC in vitro and treatment of XIAP-transfected SH-SY5Y cells with a PKC activator, phorbol 12-myristate 13-acetate (PMA) induced phosphorylation of XIAP at Ser(87) .	Tetradecanoylphorbol Acetate	142-173	X-linked inhibitor of apoptosis	Homo sapiens	89-93
21707856-8	2011	RESULTS: Recombinant XIAP was phosphorylated at Ser(87) by PKC in vitro and treatment of XIAP-transfected SH-SY5Y cells with a PKC activator, phorbol 12-myristate 13-acetate (PMA) induced phosphorylation of XIAP at Ser(87) .	Tetradecanoylphorbol Acetate	142-173	X-linked inhibitor of apoptosis	Homo sapiens	89-93
21707856-8	2011	RESULTS: Recombinant XIAP was phosphorylated at Ser(87) by PKC in vitro and treatment of XIAP-transfected SH-SY5Y cells with a PKC activator, phorbol 12-myristate 13-acetate (PMA) induced phosphorylation of XIAP at Ser(87) .	Tetradecanoylphorbol Acetate	175-178	X-linked inhibitor of apoptosis	Homo sapiens	21-25
21707856-8	2011	RESULTS: Recombinant XIAP was phosphorylated at Ser(87) by PKC in vitro and treatment of XIAP-transfected SH-SY5Y cells with a PKC activator, phorbol 12-myristate 13-acetate (PMA) induced phosphorylation of XIAP at Ser(87) .	Tetradecanoylphorbol Acetate	175-178	X-linked inhibitor of apoptosis	Homo sapiens	89-93
21707856-8	2011	RESULTS: Recombinant XIAP was phosphorylated at Ser(87) by PKC in vitro and treatment of XIAP-transfected SH-SY5Y cells with a PKC activator, phorbol 12-myristate 13-acetate (PMA) induced phosphorylation of XIAP at Ser(87) .	Tetradecanoylphorbol Acetate	175-178	X-linked inhibitor of apoptosis	Homo sapiens	89-93
20734334-7	2011	Topical application of DMBA/TPA to the skin resulted in well-developed carcinomas associated with decreased expression of pro-apoptotic protein such as caspase 3 and enhanced expression of antiapoptotic protein such as bcl-2 when compared with the control counterparts.	Tetradecanoylphorbol Acetate	28-31	caspase 3	Mus musculus	152-161
21415525-5	2011	St2b2-shRNA clearly suppressed TPA-induced epidermal hyperplasia and the expression of a marker of epidermal differentiation, involucrin (INV).	Tetradecanoylphorbol Acetate	31-34	sulfotransferase family 1B, member 1	Mus musculus	0-5
21415525-7	2011	Furthermore, treatment with TNFalpha-siRNA or anti-TNF receptor antibodies reduced the TPA-induced enhancement of St2b2 expression.	Tetradecanoylphorbol Acetate	87-90	sulfotransferase family 1B, member 1	Mus musculus	114-119
21415525-8	2011	Treatment with BAY 11-7082, a specific inhibitor of nuclear factor-kappa B (NF-kappaB), diminished TPA-induced St2b2 expression.	Tetradecanoylphorbol Acetate	99-102	sulfotransferase family 1B, member 1	Mus musculus	111-116
21415525-9	2011	These results suggested that enhancement of St2b2 expression by TPA treatment occurs mainly through the TNFalpha-NF-kappaB inflammatory signaling pathway, which in turn leads to increased CS concentrations in epidermal cells and hyperplasia.	Tetradecanoylphorbol Acetate	64-67	sulfotransferase family 1B, member 1	Mus musculus	44-49
21490774-4	2011	We also demonstrate that the phorbol ester, PMA, increased, while protein kinase C inhibitors reduced SR-BI-mediated HDL lipid uptake in HepG2 cells.	Tetradecanoylphorbol Acetate	44-47	scavenger receptor class B member 1	Homo sapiens	102-107
21039753-0	2011	Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cdelta/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages.	Tetradecanoylphorbol Acetate	201-226	matrix metallopeptidase 9	Homo sapiens	82-108
21039753-3	2011	The aim of the present study was to explore whether artemisinin, a natural extract from Artemisia annua, could decrease EMMPRIN and MMP-9 expression in phorbol myristate acetate (PMA)-induced macrophages by regulating the protein kinase (PK) Cdelta/c-Jun N-terminal kinase (JNK)/p38/extracellular signal-regulated kinase (ERK) pathway.	Tetradecanoylphorbol Acetate	179-182	matrix metallopeptidase 9	Homo sapiens	132-137
21047949-3	2011	In this study, we demonstrate that MA-10 mouse Leydig tumor cells express several PKC isoforms to varying levels and that the activation of PKC signaling, by phorbol 12-myristate 13-acetate (PMA) elevated the expression and phosphorylation of PKCalpha, -delta, -epsilon, and -mu/protein kinase D (PKD).	Tetradecanoylphorbol Acetate	158-189	protein kinase D1	Mus musculus	297-300
21047949-3	2011	In this study, we demonstrate that MA-10 mouse Leydig tumor cells express several PKC isoforms to varying levels and that the activation of PKC signaling, by phorbol 12-myristate 13-acetate (PMA) elevated the expression and phosphorylation of PKCalpha, -delta, -epsilon, and -mu/protein kinase D (PKD).	Tetradecanoylphorbol Acetate	191-194	protein kinase D1	Mus musculus	297-300
21047949-6	2011	PKD was capable of controlling PMA and cAMP/PKA-mediated synergism involved in the steroidogenic response.	Tetradecanoylphorbol Acetate	31-34	protein kinase D1	Mus musculus	0-3
19861506-8	2011	Elevated activities of myeloperoxidase, xanthine oxidase and skin edema formation in TPA-treated mice were also lowered by NDGA indicating a restrained inflammatory response.	Tetradecanoylphorbol Acetate	85-88	myeloperoxidase	Mus musculus	23-38
19861506-8	2011	Elevated activities of myeloperoxidase, xanthine oxidase and skin edema formation in TPA-treated mice were also lowered by NDGA indicating a restrained inflammatory response.	Tetradecanoylphorbol Acetate	85-88	xanthine dehydrogenase	Mus musculus	40-56
21646795-8	2011	Tr1 cells were defined as CD4+CD25+ T cells that predominantly produce IL-10 when costimulated with phorbol myristate acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	100-125	interleukin 10	Homo sapiens	71-76
21646795-8	2011	Tr1 cells were defined as CD4+CD25+ T cells that predominantly produce IL-10 when costimulated with phorbol myristate acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	127-130	interleukin 10	Homo sapiens	71-76
22096365-6	2011	Inversely, PMA-induced matrix-metalloproteinase-9 (MMP-9) gene expression and protein secretion were abrogated in the presence of 2-DG, and this can be partially explained by reduced nuclear factor-kappaB signaling.	Tetradecanoylphorbol Acetate	11-14	matrix metallopeptidase 9	Homo sapiens	23-49
22096365-6	2011	Inversely, PMA-induced matrix-metalloproteinase-9 (MMP-9) gene expression and protein secretion were abrogated in the presence of 2-DG, and this can be partially explained by reduced nuclear factor-kappaB signaling.	Tetradecanoylphorbol Acetate	11-14	matrix metallopeptidase 9	Homo sapiens	51-56
22163040-6	2011	In in vitro experiments, ACSL5 mRNA expression was greatly increased when inducing apoptosis in Jurkat T cells and PBMCs by Phorbol-Myristate-Acetate plus Ionomycin (PMA+Io).	Tetradecanoylphorbol Acetate	124-149	acyl-CoA synthetase long chain family member 5	Homo sapiens	25-30
22163040-6	2011	In in vitro experiments, ACSL5 mRNA expression was greatly increased when inducing apoptosis in Jurkat T cells and PBMCs by Phorbol-Myristate-Acetate plus Ionomycin (PMA+Io).	Tetradecanoylphorbol Acetate	166-169	acyl-CoA synthetase long chain family member 5	Homo sapiens	25-30
20654639-10	2010	Phorbol-12-myristate-13-acetate (PMA), a PKC activator, inhibited corticosterone-induced reduction in EAAC1 activity.	Tetradecanoylphorbol Acetate	0-31	solute carrier family 1 member 1	Rattus norvegicus	102-107
20654639-10	2010	Phorbol-12-myristate-13-acetate (PMA), a PKC activator, inhibited corticosterone-induced reduction in EAAC1 activity.	Tetradecanoylphorbol Acetate	33-36	solute carrier family 1 member 1	Rattus norvegicus	102-107
21151895-4	2010	Combination therapy with tPA plus cilostazol prevented development of hemorrhagic transformation, reduced brain edema, prevented endothelial injury via reduction MMP-9 activity, and prevented the blood-brain barrier opening by inhibiting decreased claudin-5 expression.	Tetradecanoylphorbol Acetate	25-28	claudin 5	Mus musculus	248-257
20826143-6	2010	Inhibitors of phosphatidylinositol 3-kinase (PI3-K), Akt, and phosphodiesterase 3B (PDE3B) diminished the PMA effect.	Tetradecanoylphorbol Acetate	106-109	phosphodiesterase 3B	Homo sapiens	62-82
20826143-6	2010	Inhibitors of phosphatidylinositol 3-kinase (PI3-K), Akt, and phosphodiesterase 3B (PDE3B) diminished the PMA effect.	Tetradecanoylphorbol Acetate	106-109	phosphodiesterase 3B	Homo sapiens	84-89
20131957-0	2010	Hyul-Tong-Ryung suppresses PMA-induced MMP-9 expression by inhibiting AP-1-mediated gene expression via ERK 1/2 signaling pathway in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	27-30	matrix metallopeptidase 9	Homo sapiens	39-44
20131957-0	2010	Hyul-Tong-Ryung suppresses PMA-induced MMP-9 expression by inhibiting AP-1-mediated gene expression via ERK 1/2 signaling pathway in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	27-30	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	70-74
20131957-1	2010	Our previous study has demonstrated that the methanol extract of Hyul-Tong-Ryung (HM) specifically suppresses the phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) production through the inhibition of MMP-9 mRNA expression in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	114-145	matrix metallopeptidase 9	Homo sapiens	188-193
20131957-1	2010	Our previous study has demonstrated that the methanol extract of Hyul-Tong-Ryung (HM) specifically suppresses the phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) production through the inhibition of MMP-9 mRNA expression in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	114-145	matrix metallopeptidase 9	Homo sapiens	232-237
20131957-1	2010	Our previous study has demonstrated that the methanol extract of Hyul-Tong-Ryung (HM) specifically suppresses the phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) production through the inhibition of MMP-9 mRNA expression in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	147-150	matrix metallopeptidase 9	Homo sapiens	188-193
20131957-1	2010	Our previous study has demonstrated that the methanol extract of Hyul-Tong-Ryung (HM) specifically suppresses the phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) production through the inhibition of MMP-9 mRNA expression in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	147-150	matrix metallopeptidase 9	Homo sapiens	232-237
20131957-7	2010	These results indicate that HM inhibits PMA-induced MMP-9 expression by blocking the activation of activator protein-1 (AP-1) via extracellular signal regulated kinase 1/2 (ERK 1/2) signaling pathway.	Tetradecanoylphorbol Acetate	40-43	matrix metallopeptidase 9	Homo sapiens	52-57
20131957-7	2010	These results indicate that HM inhibits PMA-induced MMP-9 expression by blocking the activation of activator protein-1 (AP-1) via extracellular signal regulated kinase 1/2 (ERK 1/2) signaling pathway.	Tetradecanoylphorbol Acetate	40-43	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	99-118
21042787-7	2010	RCAN3 inhibits HUVEC proliferation both basally and under VEGF or phorbol 12-myristate 13-acetate-stimulated conditions, however it does not modulate gene expression of the chosen inflammatory genes.	Tetradecanoylphorbol Acetate	66-97	RCAN family member 3	Homo sapiens	0-5
20455592-3	2010	Nonfused syn-trimer exhibits nearly the same S(1)-state lifetime and two-photon absorption (TPA) value as the nonfused dimer, while the nonfused anti-trimer exhibits different values.	Tetradecanoylphorbol Acetate	92-95	synemin	Homo sapiens	9-12
21124749-6	2010	We next found that propranolol dose-dependently inhibited induction of the key extracellular matrix-degrading and blood-brain barrier disrupting enzyme matrix metalloproteinase- 9 (MMP-9) by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	191-222	matrix metallopeptidase 9	Homo sapiens	152-179
21124749-6	2010	We next found that propranolol dose-dependently inhibited induction of the key extracellular matrix-degrading and blood-brain barrier disrupting enzyme matrix metalloproteinase- 9 (MMP-9) by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	191-222	matrix metallopeptidase 9	Homo sapiens	181-186
21124749-6	2010	We next found that propranolol dose-dependently inhibited induction of the key extracellular matrix-degrading and blood-brain barrier disrupting enzyme matrix metalloproteinase- 9 (MMP-9) by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	224-227	matrix metallopeptidase 9	Homo sapiens	152-179
21124749-6	2010	We next found that propranolol dose-dependently inhibited induction of the key extracellular matrix-degrading and blood-brain barrier disrupting enzyme matrix metalloproteinase- 9 (MMP-9) by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	224-227	matrix metallopeptidase 9	Homo sapiens	181-186
20458747-0	2010	12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression.	Tetradecanoylphorbol Acetate	0-36	matrix metallopeptidase 9	Homo sapiens	138-143
20458747-1	2010	An increase in MMP-9 gene expression and enzyme activity with stimulating the migration of GBM8401 glioma cells via wound healing assay by 12-O-tetradecanoylphorbol-13-acetate (TPA) was detected in glioblastoma cells GBM8401.	Tetradecanoylphorbol Acetate	139-175	matrix metallopeptidase 9	Homo sapiens	15-20
20458747-1	2010	An increase in MMP-9 gene expression and enzyme activity with stimulating the migration of GBM8401 glioma cells via wound healing assay by 12-O-tetradecanoylphorbol-13-acetate (TPA) was detected in glioblastoma cells GBM8401.	Tetradecanoylphorbol Acetate	177-180	matrix metallopeptidase 9	Homo sapiens	15-20
20554224-1	2010	Treatment rates with intravenously administered tissue plasminogen activator (IV-tPA) in acute ischemic stroke (IS) remain low in Asian populations.	Tetradecanoylphorbol Acetate	81-84	chromosome 20 open reading frame 181	Homo sapiens	48-76
21047770-4	2010	To understand the underlying mechanism, we showed that CADPE significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced increases in MMP-9 expression and activity in a dose-dependent manner.	Tetradecanoylphorbol Acetate	85-116	matrix metallopeptidase 9	Homo sapiens	144-149
21047770-4	2010	To understand the underlying mechanism, we showed that CADPE significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced increases in MMP-9 expression and activity in a dose-dependent manner.	Tetradecanoylphorbol Acetate	118-121	matrix metallopeptidase 9	Homo sapiens	144-149
20670683-5	2010	NCX (1 nM-50 muM) dose-dependently inhibited phorbol 12-myristate 13-acetate (PMA)-induced TNF-alpha release from monocytes (IC(50)=240 nM) and MDM (IC(50)=52 nM).	Tetradecanoylphorbol Acetate	78-81	T cell leukemia homeobox 2	Homo sapiens	0-3
20670683-8	2010	Likewise, NCX was more effective than pravastatin and the other NO donors in inhibiting PMA-induced NF-kappaB translocation in both cell types, and, at the highest concentration, significantly (P&lt;0.05) enhanced PPARgamma protein expression in monocytes.	Tetradecanoylphorbol Acetate	88-91	T cell leukemia homeobox 2	Homo sapiens	10-13
20696763-7	2010	ERK1/2 are also activated in most cells by phorbol 12-myristate 13-acetate, a classical inhibitor of agrin-induced AChR clustering in myotubes.	Tetradecanoylphorbol Acetate	43-74	agrin	Homo sapiens	101-106
20810567-0	2010	Differential role of PKC isoforms in GnRH and phorbol 12-myristate 13-acetate activation of extracellular signal-regulated kinase and Jun N-terminal kinase.	Tetradecanoylphorbol Acetate	46-77	mitogen-activated protein kinase 8	Mus musculus	134-155
20601426-10	2010	Stable depletion of GEP100 decreased phagocytosis of serum-treated zymosan and IgG-coated latex beads by human monocyte-macrophage-like U937 cells differentiated with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	167-198	IQ motif and Sec7 domain ArfGEF 1	Homo sapiens	20-26
20574434-4	2010	CD4+CD25+ cells isolated from the SDLNs of BALB/c mice, 24 and 96  hours after topical treatment with 1,25(OH)(2)D(3), consistently expressed increased IL-2 mRNA levels and also secreted enhanced quantities of IL-2 after ex vivo stimulation with phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	246-277	CD4 antigen	Mus musculus	0-3
20652762-0	2010	Alpha-mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells.	Tetradecanoylphorbol Acetate	27-58	matrix metallopeptidase 9	Homo sapiens	73-78
20652762-1	2010	The purpose of this study is to investigate the anti-metastatic effect of alpha-mangostin on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in A549 human lung adenocarcinoma cells.	Tetradecanoylphorbol Acetate	93-124	matrix metallopeptidase 9	Homo sapiens	178-204
20652762-1	2010	The purpose of this study is to investigate the anti-metastatic effect of alpha-mangostin on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in A549 human lung adenocarcinoma cells.	Tetradecanoylphorbol Acetate	93-124	matrix metallopeptidase 9	Homo sapiens	206-211
20652762-1	2010	The purpose of this study is to investigate the anti-metastatic effect of alpha-mangostin on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in A549 human lung adenocarcinoma cells.	Tetradecanoylphorbol Acetate	126-129	matrix metallopeptidase 9	Homo sapiens	178-204
20652762-1	2010	The purpose of this study is to investigate the anti-metastatic effect of alpha-mangostin on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in A549 human lung adenocarcinoma cells.	Tetradecanoylphorbol Acetate	126-129	matrix metallopeptidase 9	Homo sapiens	206-211
20417648-7	2010	Thrombin also decreased TER after depletion of conventional and novel Ca(2+)-dependent PKC isoforms using phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	106-137	protein kinase C zeta	Homo sapiens	87-90
20417648-7	2010	Thrombin also decreased TER after depletion of conventional and novel Ca(2+)-dependent PKC isoforms using phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	139-142	protein kinase C zeta	Homo sapiens	87-90
20564234-7	2010	We demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment of the airway epithelial cell line NCI-H292 increases MUC8 gene and AP2 alpha expression.	Tetradecanoylphorbol Acetate	21-52	transcription factor AP-2 alpha	Homo sapiens	137-146
20564234-7	2010	We demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment of the airway epithelial cell line NCI-H292 increases MUC8 gene and AP2 alpha expression.	Tetradecanoylphorbol Acetate	54-57	transcription factor AP-2 alpha	Homo sapiens	137-146
20564234-15	2010	From these results, we concluded that PMA induces MUC8 gene expression through a mechanism involving PKC, ERK1/2, and AP2 alpha activation in human airway epithelial cells.	Tetradecanoylphorbol Acetate	38-41	transcription factor AP-2 alpha	Homo sapiens	118-127
20479004-8	2010	Moreover, PD98059, a specific inhibitor of MEK1/2, and juglone, a potent Pin1 inhibitor, significantly suppressed the TPA-induced expression of E2F-4 as well as Egr-1 transcription factors, which control LC-3 gene expression.	Tetradecanoylphorbol Acetate	118-121	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	204-208
20590612-0	2010	Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activator protein-1.	Tetradecanoylphorbol Acetate	174-205	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	252-271
20590612-6	2010	In these cells, metformin also suppressed phorbol-12-myristate-13-acetate (PMA)-enhanced levels of matrix metalloproteinases-9 (MMP-9) protein, mRNA and transcription activity through suppression of activator protein-1 (AP-1) activation.	Tetradecanoylphorbol Acetate	42-73	matrix metallopeptidase 9	Homo sapiens	99-126
20590612-6	2010	In these cells, metformin also suppressed phorbol-12-myristate-13-acetate (PMA)-enhanced levels of matrix metalloproteinases-9 (MMP-9) protein, mRNA and transcription activity through suppression of activator protein-1 (AP-1) activation.	Tetradecanoylphorbol Acetate	42-73	matrix metallopeptidase 9	Homo sapiens	128-133
20590612-6	2010	In these cells, metformin also suppressed phorbol-12-myristate-13-acetate (PMA)-enhanced levels of matrix metalloproteinases-9 (MMP-9) protein, mRNA and transcription activity through suppression of activator protein-1 (AP-1) activation.	Tetradecanoylphorbol Acetate	42-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	199-218
20590612-6	2010	In these cells, metformin also suppressed phorbol-12-myristate-13-acetate (PMA)-enhanced levels of matrix metalloproteinases-9 (MMP-9) protein, mRNA and transcription activity through suppression of activator protein-1 (AP-1) activation.	Tetradecanoylphorbol Acetate	42-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	220-224
20590612-6	2010	In these cells, metformin also suppressed phorbol-12-myristate-13-acetate (PMA)-enhanced levels of matrix metalloproteinases-9 (MMP-9) protein, mRNA and transcription activity through suppression of activator protein-1 (AP-1) activation.	Tetradecanoylphorbol Acetate	75-78	matrix metallopeptidase 9	Homo sapiens	99-126
20590612-6	2010	In these cells, metformin also suppressed phorbol-12-myristate-13-acetate (PMA)-enhanced levels of matrix metalloproteinases-9 (MMP-9) protein, mRNA and transcription activity through suppression of activator protein-1 (AP-1) activation.	Tetradecanoylphorbol Acetate	75-78	matrix metallopeptidase 9	Homo sapiens	128-133
20590612-6	2010	In these cells, metformin also suppressed phorbol-12-myristate-13-acetate (PMA)-enhanced levels of matrix metalloproteinases-9 (MMP-9) protein, mRNA and transcription activity through suppression of activator protein-1 (AP-1) activation.	Tetradecanoylphorbol Acetate	75-78	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	199-218
20590612-6	2010	In these cells, metformin also suppressed phorbol-12-myristate-13-acetate (PMA)-enhanced levels of matrix metalloproteinases-9 (MMP-9) protein, mRNA and transcription activity through suppression of activator protein-1 (AP-1) activation.	Tetradecanoylphorbol Acetate	75-78	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	220-224
20590612-10	2010	CONCLUSIONS AND IMPLICATIONS: Metformin inhibited PMA-induced invasion and migration of human fibrosarcoma cells via Ca(2+)-dependent PKCalpha/ERK and JNK/AP-1-signalling pathways.	Tetradecanoylphorbol Acetate	50-53	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	155-159
20188123-4	2010	Activation of chicken NK-cells with PMA/Ionomycin or with the NK target cell-line LSCC-RP9 resulted in increased expression of CD107 (LAMP-1) and a newly developed flow cytometry based cytotoxicity assay showed that NK-cells were able to kill target cells.	Tetradecanoylphorbol Acetate	36-39	lysosomal associated membrane protein 1	Gallus gallus	134-140
19943262-3	2010	Bergamottin reduced phorbol-12-myristate-13-acetate (PMA)-induced activation of MMP-9 and MMP-2 and further inhibited cell invasion and migration.	Tetradecanoylphorbol Acetate	20-51	matrix metallopeptidase 9	Homo sapiens	80-85
19943262-3	2010	Bergamottin reduced phorbol-12-myristate-13-acetate (PMA)-induced activation of MMP-9 and MMP-2 and further inhibited cell invasion and migration.	Tetradecanoylphorbol Acetate	53-56	matrix metallopeptidase 9	Homo sapiens	80-85
20444294-14	2010	Then we showed that TPA not only up regulated miR-101 expression, but also reduced protein level of EZH2, EED and H3K27me3 in HepG2 cells.	Tetradecanoylphorbol Acetate	20-23	embryonic ectoderm development	Homo sapiens	106-109
20444294-15	2010	Using lenti-virus-mediated shRNA to knockdown endogenous PKCalpha expression, we observed that TPA induced growth arrest, elevation of miR-101 and reduction of EZH2, EED and H3K27me3 proteins were all PKCalpha dependent.	Tetradecanoylphorbol Acetate	95-98	embryonic ectoderm development	Homo sapiens	166-169
20213728-0	2010	CARM1 activates myogenin gene via PCAF in the early differentiation of TPA-induced rhabdomyosarcoma-derived cells.	Tetradecanoylphorbol Acetate	71-74	coactivator associated arginine methyltransferase 1	Homo sapiens	0-5
20213728-3	2010	Here, we show that CARM1 can be recruited to the promoter of myogenin gene to enhance its transcriptional activation via PCAF at the early stage of TPA-induced RD cell differentiation.	Tetradecanoylphorbol Acetate	148-151	coactivator associated arginine methyltransferase 1	Homo sapiens	19-24
20213728-6	2010	We suggest that the physical interaction of CARM1 and PCAF is likely pivotal for the activation of PCAF in the downstream of CARM1 pathway for inducing myogenin under TPA-induced differentiation.	Tetradecanoylphorbol Acetate	167-170	coactivator associated arginine methyltransferase 1	Homo sapiens	44-49
20213728-6	2010	We suggest that the physical interaction of CARM1 and PCAF is likely pivotal for the activation of PCAF in the downstream of CARM1 pathway for inducing myogenin under TPA-induced differentiation.	Tetradecanoylphorbol Acetate	167-170	coactivator associated arginine methyltransferase 1	Homo sapiens	125-130
20388733-3	2010	The TPA-responsive PKC isoform PKCdelta directly binds paxillin in a yeast two-hybrid assay and phosphorylates paxillin at T538 in vitro and also co-immunoprecipitates with paxillin and mediates phosphorylation of this residue in vivo.	Tetradecanoylphorbol Acetate	4-7	protein kinase C, delta	Mus musculus	31-39
20206692-5	2010	Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response.	Tetradecanoylphorbol Acetate	183-219	vitamin D receptor	Homo sapiens	90-93
20206692-5	2010	Interestingly, nuclear factor-kappaB (NF-kappaB) signaling, which is critical for 1,25-VD/VDR activity was found reduced in LNCaP-R cells, thereby treatment with NF-kappaB activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), can sensitize LNCaP-R vitamin D response.	Tetradecanoylphorbol Acetate	221-224	vitamin D receptor	Homo sapiens	90-93
20163138-1	2010	NADPH oxidase 4 (Nox4) is constitutively active, while Nox2 requires the cytosolic regulatory subunits p47(phox) and p67(phox) and activated Rac with activation by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	164-195	cytochrome b-245 beta chain	Homo sapiens	55-59
20163138-1	2010	NADPH oxidase 4 (Nox4) is constitutively active, while Nox2 requires the cytosolic regulatory subunits p47(phox) and p67(phox) and activated Rac with activation by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	197-200	cytochrome b-245 beta chain	Homo sapiens	55-59
20035145-5	2010	Tc1/Tc2 and Th1/Th2 were determined by analyzing intracellular cytokine staining for IFN-gamma and IL-4 in peripheral blood CD8+ and CD4+ T cells using flow cytometry after stimulation with phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	190-221	transcriptional and immune response regulator	Homo sapiens	0-3
20080871-3	2010	Immunohistochemistry and Western blot experiments in 4B cells revealed time-dependent nuclear translocation of TORC1,TORC 2, and TORC3 by forskolin [but not by the phorbol ester, phorbol 12-myristate 13-acetate (PMA)] in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	212-215	CREB regulated transcription coactivator 2	Homo sapiens	117-123
20072156-3	2010	Here, we provide the first demonstration that onzin expression is significantly downregulated during differentiation induction of acute myeloid leukemic (AML) cell lines and primary cells by all-trans retinoic acid (ATRA) and especially by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	240-271	placenta associated 8	Homo sapiens	46-51
20072156-3	2010	Here, we provide the first demonstration that onzin expression is significantly downregulated during differentiation induction of acute myeloid leukemic (AML) cell lines and primary cells by all-trans retinoic acid (ATRA) and especially by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	273-276	placenta associated 8	Homo sapiens	46-51
20053986-2	2010	To bind to its target AP-1/12-O-tetradecanoylphorbol-13-acetate-responsive element or cAMP-responsive element DNA sequences in gene promoters and exert its transcriptional part, c-Fos must heterodimerize with other bZip proteins, its best studied partners being the Jun proteins (c-Jun, JunB, and JunD).	Tetradecanoylphorbol Acetate	27-63	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-183
20053986-2	2010	To bind to its target AP-1/12-O-tetradecanoylphorbol-13-acetate-responsive element or cAMP-responsive element DNA sequences in gene promoters and exert its transcriptional part, c-Fos must heterodimerize with other bZip proteins, its best studied partners being the Jun proteins (c-Jun, JunB, and JunD).	Tetradecanoylphorbol Acetate	27-63	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	280-285
20053986-5	2010	Whereas monomeric c-Fos is highly mobile and distributed evenly with nucleolar exclusion in the nucleus, heterodimerization with c-Jun entails intranuclear redistribution and dramatic reduction in mobility of c-Fos caused by predominant association with the nuclear matrix independently of any binding to AP-1/12-O-tetradecanoylphorbol-13-acetate-responsive element or cAMP-responsive element sequences.	Tetradecanoylphorbol Acetate	310-346	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	129-134
20053986-5	2010	Whereas monomeric c-Fos is highly mobile and distributed evenly with nucleolar exclusion in the nucleus, heterodimerization with c-Jun entails intranuclear redistribution and dramatic reduction in mobility of c-Fos caused by predominant association with the nuclear matrix independently of any binding to AP-1/12-O-tetradecanoylphorbol-13-acetate-responsive element or cAMP-responsive element sequences.	Tetradecanoylphorbol Acetate	310-346	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	209-214
20043135-0	2010	Cordycepin inhibits TPA-induced matrix metalloproteinase-9 expression by suppressing the MAPK/AP-1 pathway in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	20-23	matrix metallopeptidase 9	Homo sapiens	32-58
20043135-9	2010	Cordycepin inhibits TPA-induced MMP-9 expression and cell invasion by suppressing AP-1 activation.	Tetradecanoylphorbol Acetate	20-23	matrix metallopeptidase 9	Homo sapiens	32-37
20043135-11	2010	Cordycepin is a potent inhibitor of TPA-induced MMP-9 expression and blocks strongly the ability of AP-1 activation via MAPK signaling pathway in MCF-7 cells.	Tetradecanoylphorbol Acetate	36-39	matrix metallopeptidase 9	Homo sapiens	48-53
19784811-0	2010	Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages.	Tetradecanoylphorbol Acetate	37-68	retinoid X receptor alpha	Homo sapiens	0-19
19784811-0	2010	Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages.	Tetradecanoylphorbol Acetate	70-73	retinoid X receptor alpha	Homo sapiens	0-19
19784811-9	2010	In the presence of the RXR agonists 9-cis retinoic acid or SR11237, PMA-induced THP-1 cells became less adherent, showed decreased macrophage-like morphological changes, decreased cell surface antigen CD11b and CD36 expression, and down regulated the phagocytosis of latex beads and the production of TNF-alpha and MMP-9.	Tetradecanoylphorbol Acetate	68-71	retinoid X receptor alpha	Homo sapiens	23-26
19784811-9	2010	In the presence of the RXR agonists 9-cis retinoic acid or SR11237, PMA-induced THP-1 cells became less adherent, showed decreased macrophage-like morphological changes, decreased cell surface antigen CD11b and CD36 expression, and down regulated the phagocytosis of latex beads and the production of TNF-alpha and MMP-9.	Tetradecanoylphorbol Acetate	68-71	matrix metallopeptidase 9	Homo sapiens	315-320
19784811-10	2010	These data suggest that RXR agonists inhibit PMA-induced THP-1 cell differentiation into macrophage-like cells, which may be helpful in understanding the anti-atherosclerotic effect of RXR and its agonists.	Tetradecanoylphorbol Acetate	45-48	retinoid X receptor alpha	Homo sapiens	24-27
19784811-10	2010	These data suggest that RXR agonists inhibit PMA-induced THP-1 cell differentiation into macrophage-like cells, which may be helpful in understanding the anti-atherosclerotic effect of RXR and its agonists.	Tetradecanoylphorbol Acetate	45-48	retinoid X receptor alpha	Homo sapiens	185-188
20026244-2	2010	In this study, we examined whether alpha-synuclein, a major components of Lewy body that has been implicated in the modulation of neuroinflammation, regulates MMP-9 and tPA activity, which plays important roles in neurodegeneration as well as regeneration processes, in cultured rat primary glial cells.	Tetradecanoylphorbol Acetate	169-172	synuclein alpha	Rattus norvegicus	35-50
20026244-5	2010	In contrast, the activity of tPA was decreased by alpha-synuclein with only marginal changes in the level of mRNA encoding tPA, if any.	Tetradecanoylphorbol Acetate	29-32	synuclein alpha	Rattus norvegicus	50-65
20026244-8	2010	Treatment of alpha-synuclein increased the phosphorylation of ERK1/2 and the inhibition of ERK1/2 reversed the changes in MMP-9 and tPA activity.	Tetradecanoylphorbol Acetate	132-135	synuclein alpha	Rattus norvegicus	13-28
20798497-1	2010	BACKGROUND: In this report, we explored the role of PKCalpha and PKCe as mediators of phorbol 12-myristate13-acetate (PMA)-induced proliferation in pituitary tumor GH3B6 cells, and determined if the ERK1/2 and Akt pathways were activated.	Tetradecanoylphorbol Acetate	118-121	protein kinase C, alpha	Rattus norvegicus	52-60
20798497-5	2010	RESULTS: Incubation with PMA for 15 min stimulated PKCalpha and PKCe activation, which was correlated with the phosphorylation of ERK1/2 but not Akt.	Tetradecanoylphorbol Acetate	25-28	protein kinase C, alpha	Rattus norvegicus	51-59
20492173-1	2010	This study first investigates the anti-metastatic effect of alpha-mangostin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in human breast adenocarcinoma cells, MCF-7.	Tetradecanoylphorbol Acetate	79-115	matrix metallopeptidase 9	Homo sapiens	197-202
20492173-1	2010	This study first investigates the anti-metastatic effect of alpha-mangostin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in human breast adenocarcinoma cells, MCF-7.	Tetradecanoylphorbol Acetate	117-120	matrix metallopeptidase 9	Homo sapiens	197-202
20492173-3	2010	Data also showed alpha-mangostin could inhibit the activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) involved in the downregulation the enzyme activities, protein, and messenger RNA levels of MMP-2 and MMP-9 induced by TPA.	Tetradecanoylphorbol Acetate	238-241	matrix metallopeptidase 9	Homo sapiens	221-226
20492173-4	2010	Next, alpha-mangostin also strongly inhibited TPA-induced degradation of inhibitor of kappaBalpha (IkappaBalpha) and the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun.	Tetradecanoylphorbol Acetate	46-49	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	175-180
20492173-4	2010	Next, alpha-mangostin also strongly inhibited TPA-induced degradation of inhibitor of kappaBalpha (IkappaBalpha) and the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun.	Tetradecanoylphorbol Acetate	46-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	186-191
20492173-6	2010	Further, the treatment of specific inhibitor for ERK (U0126) to MCF-7 cells could inhibit TPA-induced MMP-2 and MMP-9 expressions along with an inhibition on cell invasion and migration.	Tetradecanoylphorbol Acetate	90-93	matrix metallopeptidase 9	Homo sapiens	112-117
20492175-0	2010	Acacetin inhibits TPA-induced MMP-2 and u-PA expressions of human lung cancer cells through inactivating JNK signaling pathway and reducing binding activities of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	18-21	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	176-180
19626033-6	2010	Unexpectedly, topical treatment of K14-RIP4 mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced dramatic, neutrophilic inflammation, an effect that was independent of tumor necrosis factor type 1 receptor (TNFR1/p55) function.	Tetradecanoylphorbol Acetate	54-90	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	221-224
19626033-6	2010	Unexpectedly, topical treatment of K14-RIP4 mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced dramatic, neutrophilic inflammation, an effect that was independent of tumor necrosis factor type 1 receptor (TNFR1/p55) function.	Tetradecanoylphorbol Acetate	92-95	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	215-220
19626033-6	2010	Unexpectedly, topical treatment of K14-RIP4 mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced dramatic, neutrophilic inflammation, an effect that was independent of tumor necrosis factor type 1 receptor (TNFR1/p55) function.	Tetradecanoylphorbol Acetate	92-95	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	221-224
19804834-1	2010	In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation, an increase in the migration/invasion of U87 glioblastoma cells was detected by a wound healing assay, transwell analysis, and spheroid formation assay by inducing matrix metalloproteinase-9 (MMP-9) enzyme activity via a gelatin zymographic analysis.	Tetradecanoylphorbol Acetate	19-55	small nucleolar RNA, C/D box 87	Homo sapiens	116-119
19804834-1	2010	In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation, an increase in the migration/invasion of U87 glioblastoma cells was detected by a wound healing assay, transwell analysis, and spheroid formation assay by inducing matrix metalloproteinase-9 (MMP-9) enzyme activity via a gelatin zymographic analysis.	Tetradecanoylphorbol Acetate	19-55	matrix metallopeptidase 9	Homo sapiens	239-265
19804834-1	2010	In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation, an increase in the migration/invasion of U87 glioblastoma cells was detected by a wound healing assay, transwell analysis, and spheroid formation assay by inducing matrix metalloproteinase-9 (MMP-9) enzyme activity via a gelatin zymographic analysis.	Tetradecanoylphorbol Acetate	19-55	matrix metallopeptidase 9	Homo sapiens	267-272
19804834-1	2010	In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation, an increase in the migration/invasion of U87 glioblastoma cells was detected by a wound healing assay, transwell analysis, and spheroid formation assay by inducing matrix metalloproteinase-9 (MMP-9) enzyme activity via a gelatin zymographic analysis.	Tetradecanoylphorbol Acetate	57-60	small nucleolar RNA, C/D box 87	Homo sapiens	116-119
19804834-1	2010	In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation, an increase in the migration/invasion of U87 glioblastoma cells was detected by a wound healing assay, transwell analysis, and spheroid formation assay by inducing matrix metalloproteinase-9 (MMP-9) enzyme activity via a gelatin zymographic analysis.	Tetradecanoylphorbol Acetate	57-60	matrix metallopeptidase 9	Homo sapiens	239-265
19804834-1	2010	In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation, an increase in the migration/invasion of U87 glioblastoma cells was detected by a wound healing assay, transwell analysis, and spheroid formation assay by inducing matrix metalloproteinase-9 (MMP-9) enzyme activity via a gelatin zymographic analysis.	Tetradecanoylphorbol Acetate	57-60	matrix metallopeptidase 9	Homo sapiens	267-272
19804834-2	2010	A dose- and time-dependent increase in cyclooxygenase-2 (COX-2) gene expression with elevated prostaglandin E(2) (PGE(2)) production was identified in TPA- but not in 4alpha-TPA (a respective inactive compound)-treated U87 cells TPA-induced migration/invasion was significantly blocked by adding the COX-2-specific inhibitor, NS398, through a reduction in PGE(2) production.	Tetradecanoylphorbol Acetate	151-154	small nucleolar RNA, C/D box 87	Homo sapiens	219-222
19804834-3	2010	Data from the pharmacological studies using specific chemical inhibitors showed that activation of protein kinase C (PKC) and extracellular signal-regulated kinases (ERKs) was involved in TPA-induced migration/invasion, COX-2 protein expression, and MMP-9 activation.	Tetradecanoylphorbol Acetate	188-191	matrix metallopeptidase 9	Homo sapiens	250-255
19853631-6	2010	In addition, the c-Jun mutant blocked the IP activity stimulated by TPA.	Tetradecanoylphorbol Acetate	68-71	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-22
19857463-3	2009	The megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of NRP-1 mRNA and protein expression and by an increase in VEGF-binding activity, which was mainly mediated by VEGFR-2.	Tetradecanoylphorbol Acetate	71-96	kinase insert domain receptor	Homo sapiens	256-263
19857463-3	2009	The megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of NRP-1 mRNA and protein expression and by an increase in VEGF-binding activity, which was mainly mediated by VEGFR-2.	Tetradecanoylphorbol Acetate	98-101	kinase insert domain receptor	Homo sapiens	256-263
18691343-2	2009	Intracellular interleukin-4 (Th2 cytokine) and interferon-gamma (Th1 cytokine) production was assessed in CD4+ T lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin using flow cytometry.	Tetradecanoylphorbol Acetate	138-169	negative elongation factor complex member C/D	Homo sapiens	65-68
19715751-0	2009	Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells.	Tetradecanoylphorbol Acetate	19-22	matrix metallopeptidase 9	Homo sapiens	31-36
19715751-2	2009	In a previous study, we reported that silibinin suppresses TPA-induced MMP-9 expression through the Raf/MEK/ERK pathway.	Tetradecanoylphorbol Acetate	59-62	matrix metallopeptidase 9	Homo sapiens	71-76
19715751-3	2009	AIMS OF THE STUDY: Herein we determined the co-relationship between MMP-9 and COX-2, as well as the effect of silibinin on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 and COX-2 expression in the human breast cancer cells, MCF-7 and MDA-MB231.	Tetradecanoylphorbol Acetate	123-160	matrix metallopeptidase 9	Homo sapiens	175-180
19715751-7	2009	RESULTS: The expression of MMP-9 and COX-2 in response to TPA was increased, whereas TPA-induced MMP-9 and COX-2 expression was decreased by silibinin.	Tetradecanoylphorbol Acetate	58-61	matrix metallopeptidase 9	Homo sapiens	27-32
19715751-7	2009	RESULTS: The expression of MMP-9 and COX-2 in response to TPA was increased, whereas TPA-induced MMP-9 and COX-2 expression was decreased by silibinin.	Tetradecanoylphorbol Acetate	85-88	matrix metallopeptidase 9	Homo sapiens	97-102
19715751-8	2009	Our results showed that TPA-induced MMP-9 expression was inhibited by celecoxib in a dose-dependent fashion, but not MMP-1-expression.	Tetradecanoylphorbol Acetate	24-27	matrix metallopeptidase 9	Homo sapiens	36-41
19715751-10	2009	In contrast, TPA-induced MMP-9 and COX-2 expression was decreased by UO126 (MEK 1/2 inhibitor).	Tetradecanoylphorbol Acetate	13-16	matrix metallopeptidase 9	Homo sapiens	25-30
19715751-11	2009	CONCLUSION: Silibinin down-regulates TPA-induced MMP-9 expression through inhibition of COX-2 expression in breast cancer cells.	Tetradecanoylphorbol Acetate	37-40	matrix metallopeptidase 9	Homo sapiens	49-54
21060209-5	2011	The TPA-induced expression of PDGF-B mRNA and PDGF-BB protein levels in culture media was significantly decreased by treatment with PPARalpha activators, Wy14643 and fenofibric acid, in a dose-dependent manner.	Tetradecanoylphorbol Acetate	4-7	platelet derived growth factor subunit B	Homo sapiens	30-36
20961851-4	2010	We showed that inhibiting PKC with GF1 or activating it with phorbol 12-myristate 13-acetate potentiated and inhibited agonist-induced Ca(2+) entry, respectively, into cells expressing TRPC6.	Tetradecanoylphorbol Acetate	61-92	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	185-190
20131957-7	2010	These results indicate that HM inhibits PMA-induced MMP-9 expression by blocking the activation of activator protein-1 (AP-1) via extracellular signal regulated kinase 1/2 (ERK 1/2) signaling pathway.	Tetradecanoylphorbol Acetate	40-43	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-124
20728597-7	2010	Interestingly, maximal IL-2 production and CD4(+) T cell cycle progression are observed upon activation with soluble anti-CD3 and phorbol 12-myristate 13-acetate (PMA), a phorbol ester.	Tetradecanoylphorbol Acetate	130-161	CD4 antigen	Mus musculus	43-46
20728597-7	2010	Interestingly, maximal IL-2 production and CD4(+) T cell cycle progression are observed upon activation with soluble anti-CD3 and phorbol 12-myristate 13-acetate (PMA), a phorbol ester.	Tetradecanoylphorbol Acetate	163-166	CD4 antigen	Mus musculus	43-46
20458747-3	2010	Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125.	Tetradecanoylphorbol Acetate	119-122	matrix metallopeptidase 9	Homo sapiens	145-150
20458747-4	2010	Activation of NF-kappaB protein p65 nuclear translocation and IkappaBalpha protein phosphorylation with increased NF-kappaB-directed luciferase activity by TPA were observed, and these were blocked by the PD98059 and IkB inhibitor BAY117082 accompanied by reducing migration and MMP-9 activity induced by TPA in GBM8401 cells.	Tetradecanoylphorbol Acetate	156-159	matrix metallopeptidase 9	Homo sapiens	279-284
20458747-4	2010	Activation of NF-kappaB protein p65 nuclear translocation and IkappaBalpha protein phosphorylation with increased NF-kappaB-directed luciferase activity by TPA were observed, and these were blocked by the PD98059 and IkB inhibitor BAY117082 accompanied by reducing migration and MMP-9 activity induced by TPA in GBM8401 cells.	Tetradecanoylphorbol Acetate	305-308	matrix metallopeptidase 9	Homo sapiens	279-284
20458747-5	2010	Transfection of GBM8401 cells with PKCalpha siRNA specifically reduced PKCalpha protein expression with blocking TPA-induced MMP-9 activation and migration.	Tetradecanoylphorbol Acetate	113-116	matrix metallopeptidase 9	Homo sapiens	125-130
20627998-6	2010	Pretreatment with E6201 cream attenuated phorbol-12 myristate 13-acetate-induced ornithine decarboxylase activity, a marker of proliferation in epidermis.	Tetradecanoylphorbol Acetate	41-72	ornithine decarboxylase, structural 1	Mus musculus	81-104
20696233-7	2010	Furthermore, butein repressed the expression of VEGF and MMP-9 induced by treatment with tumor necrosis factor-alpha and phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	121-152	matrix metallopeptidase 9	Homo sapiens	57-62
20610768-5	2010	Using a cell surface biotinylation assay, we showed that PKC activation with phorbol 12-myristate 13-acetate (PMA) increased (approximately 3-fold) cell surface levels of TRPM4-GFP protein in &lt;10 min.	Tetradecanoylphorbol Acetate	77-108	protein kinase C, alpha	Rattus norvegicus	57-60
20610768-5	2010	Using a cell surface biotinylation assay, we showed that PKC activation with phorbol 12-myristate 13-acetate (PMA) increased (approximately 3-fold) cell surface levels of TRPM4-GFP protein in &lt;10 min.	Tetradecanoylphorbol Acetate	77-108	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	171-180
20610768-5	2010	Using a cell surface biotinylation assay, we showed that PKC activation with phorbol 12-myristate 13-acetate (PMA) increased (approximately 3-fold) cell surface levels of TRPM4-GFP protein in &lt;10 min.	Tetradecanoylphorbol Acetate	110-113	protein kinase C, alpha	Rattus norvegicus	57-60
20610768-5	2010	Using a cell surface biotinylation assay, we showed that PKC activation with phorbol 12-myristate 13-acetate (PMA) increased (approximately 3-fold) cell surface levels of TRPM4-GFP protein in &lt;10 min.	Tetradecanoylphorbol Acetate	110-113	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	171-180
20610768-8	2010	PMA-induced translocation of TRPM4 to the plasma membrane was independent of PKCalpha and PKCbeta activity but was inhibited by blockade of PKCdelta with rottlerin.	Tetradecanoylphorbol Acetate	0-3	transient receptor potential cation channel, subfamily M, member 4	Rattus norvegicus	29-34
20610768-8	2010	PMA-induced translocation of TRPM4 to the plasma membrane was independent of PKCalpha and PKCbeta activity but was inhibited by blockade of PKCdelta with rottlerin.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	77-85
20610768-8	2010	PMA-induced translocation of TRPM4 to the plasma membrane was independent of PKCalpha and PKCbeta activity but was inhibited by blockade of PKCdelta with rottlerin.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, beta	Rattus norvegicus	90-97
20336681-6	2010	Moreover, 6-shogaol markedly suppressed TPA-induced activation of extracellular signal-regulate kinase1/2, p38 mitogen-activated protein kinase, JNK1/2, and phosphatidylinositol 3-kinase/Akt, which are upstream of nuclear factor-kappaB and AP-1.	Tetradecanoylphorbol Acetate	40-43	mitogen-activated protein kinase 8	Mus musculus	145-151
20582552-4	2010	Phorbol 12-myristate 13-acetate (PMA) treatment for 5637 bladder cancer cells increased COX-2 expression, slightly induced Slug expression, and decreased E-cadherin expression.	Tetradecanoylphorbol Acetate	0-31	snail family transcriptional repressor 2	Homo sapiens	123-127
20582552-4	2010	Phorbol 12-myristate 13-acetate (PMA) treatment for 5637 bladder cancer cells increased COX-2 expression, slightly induced Slug expression, and decreased E-cadherin expression.	Tetradecanoylphorbol Acetate	33-36	snail family transcriptional repressor 2	Homo sapiens	123-127
20501791-8	2010	Ex-vivo rat testis culture showed that PMA induced the cleavage of the KIT extracellular domain.	Tetradecanoylphorbol Acetate	39-42	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	71-74
20590612-0	2010	Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activator protein-1.	Tetradecanoylphorbol Acetate	174-205	matrix metallopeptidase 9	Homo sapiens	73-99
20514473-0	2010	Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by apigenin via the inhibition of p38 mitogen-activated protein kinase-dependent matrix metalloproteinase-9 expression.	Tetradecanoylphorbol Acetate	15-46	matrix metallopeptidase 9	Homo sapiens	156-182
20514473-3	2010	We found that apigenin markedly inhibits the phorbol-12-myristate-13-acetate (PMA)-induced increase in MMP-9 expression and activity in several cancer cell lines.	Tetradecanoylphorbol Acetate	45-76	matrix metallopeptidase 9	Homo sapiens	103-108
20514473-3	2010	We found that apigenin markedly inhibits the phorbol-12-myristate-13-acetate (PMA)-induced increase in MMP-9 expression and activity in several cancer cell lines.	Tetradecanoylphorbol Acetate	78-81	matrix metallopeptidase 9	Homo sapiens	103-108
20514473-6	2010	We found that apigenin could inhibit PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), which was involved in the down-regulation of the expression of matrix metalloproteinase-9 (MMP-9) at mRNA levels.	Tetradecanoylphorbol Acetate	37-40	matrix metallopeptidase 9	Homo sapiens	180-206
20514473-6	2010	We found that apigenin could inhibit PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), which was involved in the down-regulation of the expression of matrix metalloproteinase-9 (MMP-9) at mRNA levels.	Tetradecanoylphorbol Acetate	37-40	matrix metallopeptidase 9	Homo sapiens	208-213
20152819-4	2010	DHA reduced PMA-induced activation of MMP-9 and MMP-2 and further inhibited cell invasion and migration.	Tetradecanoylphorbol Acetate	12-15	matrix metallopeptidase 9	Homo sapiens	38-43
20152819-5	2010	DHA suppressed PMA-enhanced expression of MMP-9 protein, mRNA, and transcriptional activity through suppressing NF-kappaB and AP-1 activation without changing the level of tissue inhibitor of metalloproteinase (TIMP)-1.	Tetradecanoylphorbol Acetate	15-18	matrix metallopeptidase 9	Homo sapiens	42-47
20152819-5	2010	DHA suppressed PMA-enhanced expression of MMP-9 protein, mRNA, and transcriptional activity through suppressing NF-kappaB and AP-1 activation without changing the level of tissue inhibitor of metalloproteinase (TIMP)-1.	Tetradecanoylphorbol Acetate	15-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	126-130
20152819-7	2010	DHA-inhibited PMA-induced NF-kappaB and c-Jun nuclear translocation, which are upstream of PMA-induced MMP-9 expression and invasion.	Tetradecanoylphorbol Acetate	14-17	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	40-45
20152819-7	2010	DHA-inhibited PMA-induced NF-kappaB and c-Jun nuclear translocation, which are upstream of PMA-induced MMP-9 expression and invasion.	Tetradecanoylphorbol Acetate	14-17	matrix metallopeptidase 9	Homo sapiens	103-108
20152819-7	2010	DHA-inhibited PMA-induced NF-kappaB and c-Jun nuclear translocation, which are upstream of PMA-induced MMP-9 expression and invasion.	Tetradecanoylphorbol Acetate	91-94	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	40-45
20152819-7	2010	DHA-inhibited PMA-induced NF-kappaB and c-Jun nuclear translocation, which are upstream of PMA-induced MMP-9 expression and invasion.	Tetradecanoylphorbol Acetate	91-94	matrix metallopeptidase 9	Homo sapiens	103-108
20431084-1	2010	BACKGROUND AND PURPOSE: Intracranial mechanical thrombectomy is a therapeutic option for acute ischemic stroke patients failing intravenous tissue plasminogen activator (IV tPA).	Tetradecanoylphorbol Acetate	173-176	chromosome 20 open reading frame 181	Homo sapiens	140-168
20491082-3	2010	CT1 and CT2 showed very strong anti-tumor-promoting activities at IC(50) 0.7 microg/ml and 0.1 microg/ml, respectively, in a convenient, short-term in vitro assay, i.e., the inhibition of Epstein-Barr virus (EBV) activation induced by phorbol 12-myristate 13-acetate (PMA) and sodium butyrate.	Tetradecanoylphorbol Acetate	235-266	cancer/testis antigen 2	Homo sapiens	8-11
20491082-3	2010	CT1 and CT2 showed very strong anti-tumor-promoting activities at IC(50) 0.7 microg/ml and 0.1 microg/ml, respectively, in a convenient, short-term in vitro assay, i.e., the inhibition of Epstein-Barr virus (EBV) activation induced by phorbol 12-myristate 13-acetate (PMA) and sodium butyrate.	Tetradecanoylphorbol Acetate	268-271	cancer/testis antigen 2	Homo sapiens	8-11
20615023-2	2010	Using this system, we are able to detect activation-dependent changes in the Raman and elastic-scattering signals from CD8+ T cells stimulated with either Staphylococcal enterotoxin B (SEB) or phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	193-218	CD8a molecule	Homo sapiens	119-122
20138977-3	2010	First, we suggest that the expression of MMP-9 by TPA involves phosphorylation of IKK, p38, and PKC in hepG2.	Tetradecanoylphorbol Acetate	50-53	matrix metallopeptidase 9	Homo sapiens	41-46
20138977-5	2010	Hesperidin significantly suppressed the TPA-induced the mRNA level of MMP-9.	Tetradecanoylphorbol Acetate	40-43	matrix metallopeptidase 9	Homo sapiens	70-75
20332816-6	2010	Moreover, PMA, an activator of PKC, induced a dramatic elevation in the m/c-PKC activity ratio, accompanied with the increase in neurite length (r=0.99, P&lt; 0.01).	Tetradecanoylphorbol Acetate	10-13	protein kinase C, gamma	Rattus norvegicus	31-34
20332816-6	2010	Moreover, PMA, an activator of PKC, induced a dramatic elevation in the m/c-PKC activity ratio, accompanied with the increase in neurite length (r=0.99, P&lt; 0.01).	Tetradecanoylphorbol Acetate	10-13	protein kinase C, gamma	Rattus norvegicus	76-79
20006981-5	2010	The PKCalpha activator, phorbol-12-myristate-13-acetate (PMA) induced the expression of VDR in the rat liver, and the induction of VDR by 1,25(OH)(2)D(3) and CDCA was inhibited by the PKCalpha inhibitor, bisindolyl maleimide I (Bis I).	Tetradecanoylphorbol Acetate	24-55	protein kinase C, alpha	Rattus norvegicus	4-12
20006981-5	2010	The PKCalpha activator, phorbol-12-myristate-13-acetate (PMA) induced the expression of VDR in the rat liver, and the induction of VDR by 1,25(OH)(2)D(3) and CDCA was inhibited by the PKCalpha inhibitor, bisindolyl maleimide I (Bis I).	Tetradecanoylphorbol Acetate	24-55	protein kinase C, alpha	Rattus norvegicus	184-192
20006981-5	2010	The PKCalpha activator, phorbol-12-myristate-13-acetate (PMA) induced the expression of VDR in the rat liver, and the induction of VDR by 1,25(OH)(2)D(3) and CDCA was inhibited by the PKCalpha inhibitor, bisindolyl maleimide I (Bis I).	Tetradecanoylphorbol Acetate	57-60	protein kinase C, alpha	Rattus norvegicus	4-12
20006981-5	2010	The PKCalpha activator, phorbol-12-myristate-13-acetate (PMA) induced the expression of VDR in the rat liver, and the induction of VDR by 1,25(OH)(2)D(3) and CDCA was inhibited by the PKCalpha inhibitor, bisindolyl maleimide I (Bis I).	Tetradecanoylphorbol Acetate	57-60	protein kinase C, alpha	Rattus norvegicus	184-192
20139271-5	2010	Stimulation with PMA/ionomycin caused splenic CD4(+)PD-1(+) T cells to secrete high levels of IFN-gamma, IL-10, low levels of TNF-alpha, faint levels of IL-2, IL-21, and no IL-4, IL-17.	Tetradecanoylphorbol Acetate	17-20	CD4 molecule	Sus scrofa	46-49
20139271-5	2010	Stimulation with PMA/ionomycin caused splenic CD4(+)PD-1(+) T cells to secrete high levels of IFN-gamma, IL-10, low levels of TNF-alpha, faint levels of IL-2, IL-21, and no IL-4, IL-17.	Tetradecanoylphorbol Acetate	17-20	interleukin 4	Sus scrofa	173-177
19952305-2	2010	The goal of this study was to develop a more clinically relevant recombinant biotherapeutic by fusing a mutant tPA with a single-chain antibody fragment (scFv) with specificity for glycophorin A (GPA) on mouse RBCs.	Tetradecanoylphorbol Acetate	111-114	glycophorin A	Mus musculus	181-194
20053683-2	2010	Here, we demonstrate that during the phorbol 12-myristate 13-acetate (PMA)-induced differentiation of HL-60 cells toward macrophages, beta-actin translocates from the cytoplasm to the nucleus and that this process is dramatically inhibited by pretreatment with p38 mitogen-activated protein kinase inhibitors.	Tetradecanoylphorbol Acetate	37-68	POTE ankyrin domain family member F	Homo sapiens	134-144
20053683-2	2010	Here, we demonstrate that during the phorbol 12-myristate 13-acetate (PMA)-induced differentiation of HL-60 cells toward macrophages, beta-actin translocates from the cytoplasm to the nucleus and that this process is dramatically inhibited by pretreatment with p38 mitogen-activated protein kinase inhibitors.	Tetradecanoylphorbol Acetate	70-73	POTE ankyrin domain family member F	Homo sapiens	134-144
20126997-8	2010	MMP-9 was stimulated by phorbol 12-myristate 13-acetate in HeLa cells and enhanced in DoTc2-4510.	Tetradecanoylphorbol Acetate	24-55	matrix metallopeptidase 9	Homo sapiens	0-5
20018888-3	2010	12-O-Tetradecanoylphorbol-13-acetate-type tumor promoters, such as phorbol 12-myristate 13-acetate (PMA) and teleocidin, increase Rac1 activity and overcome the amino-Nogo-induced inhibition of cell spreading.	Tetradecanoylphorbol Acetate	0-36	Rac family small GTPase 1	Homo sapiens	130-134
20018888-3	2010	12-O-Tetradecanoylphorbol-13-acetate-type tumor promoters, such as phorbol 12-myristate 13-acetate (PMA) and teleocidin, increase Rac1 activity and overcome the amino-Nogo-induced inhibition of cell spreading.	Tetradecanoylphorbol Acetate	67-98	Rac family small GTPase 1	Homo sapiens	130-134
20018888-3	2010	12-O-Tetradecanoylphorbol-13-acetate-type tumor promoters, such as phorbol 12-myristate 13-acetate (PMA) and teleocidin, increase Rac1 activity and overcome the amino-Nogo-induced inhibition of cell spreading.	Tetradecanoylphorbol Acetate	100-103	Rac family small GTPase 1	Homo sapiens	130-134
20082219-2	2010	In this study, we examined the inhibitory effect of bee venom (BV) and its major peptides, melittin and apamin, on PMA-induced invasion induced by MMP-9 expression in Caki-1 renal cancer cells.	Tetradecanoylphorbol Acetate	115-118	matrix metallopeptidase 9	Homo sapiens	147-152
19946336-2	2010	JWA depletion blocked the inhibitory effect of As(2)O(3) on HeLa cell migration, but enhanced cell migration after PMA treatment.	Tetradecanoylphorbol Acetate	115-118	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	0-3
20178640-11	2010	The NCF1 pseudogene expression responded robustly to PMA induction during macrophage differentiation.	Tetradecanoylphorbol Acetate	53-56	neutrophil cytosolic factor 1	Homo sapiens	4-8
20025870-7	2010	In contrast, treatment of HASM by PMA induces phosphorylation and activation of Ra, MEK1/2, ERK1/2, JNK, Elk-1, and c-Jun.	Tetradecanoylphorbol Acetate	34-37	ETS transcription factor ELK1	Homo sapiens	105-110
20025870-7	2010	In contrast, treatment of HASM by PMA induces phosphorylation and activation of Ra, MEK1/2, ERK1/2, JNK, Elk-1, and c-Jun.	Tetradecanoylphorbol Acetate	34-37	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-121
19768635-0	2010	Plumbagin inhibits TPA-induced MMP-2 and u-PA expressions by reducing binding activities of NF-kappaB and AP-1 via ERK signaling pathway in A549 human lung cancer cells.	Tetradecanoylphorbol Acetate	19-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-110
19768635-4	2010	Next, plumbagin also strongly inhibited TPA-induced phosphorylation and degradation of inhibitor of kappaBalpha (IkappaBalpha), and the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun.	Tetradecanoylphorbol Acetate	40-43	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	190-195
19768635-4	2010	Next, plumbagin also strongly inhibited TPA-induced phosphorylation and degradation of inhibitor of kappaBalpha (IkappaBalpha), and the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun.	Tetradecanoylphorbol Acetate	40-43	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	201-206
20350353-7	2010	Based on the results obtained, it can be concluded that TPA and high concentrations of other growth factors intensify the proliferation of melanocytes, without the risk of damage to the HRAS (exon 1 and 2), KRAS (exon 1 and 2), NRAS (exon 1 and 2), and BRAF (exon 11 and 15) genes.	Tetradecanoylphorbol Acetate	56-59	NRAS proto-oncogene, GTPase	Homo sapiens	228-232
20492175-5	2010	Next, acacetin also strongly inhibited TPA-stimulated the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun.	Tetradecanoylphorbol Acetate	39-42	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	112-117
20492175-5	2010	Next, acacetin also strongly inhibited TPA-stimulated the nuclear levels of nuclear factor kappa B (NF-kappaB), c-Fos, and c-Jun.	Tetradecanoylphorbol Acetate	39-42	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-128
20492175-8	2010	Taken together, these results suggest the antimetastatic effects of acacetin on the TPA-induced A549 cells might be by reducing MMP-2 and u-PA expressions through inhibiting phosphorylation of JNK and reducing NF-kappaB and AP-1 binding activities.	Tetradecanoylphorbol Acetate	84-87	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	224-228
20798838-3	2010	At present, intravenously administered tissue plasminogen activator (IV-TPA) remains the only FDA-approved therapeutic agent for the treatment of ischemic stroke within 3 hours of symptom onset.	Tetradecanoylphorbol Acetate	72-75	chromosome 20 open reading frame 181	Homo sapiens	39-67
19769987-5	2009	Although several tumor necrosis factor-alpha- and phorbol-12-myristate-13-acetate/ionomycin-induced NF-kappaB target genes are CARM1 dependent, CARM1 enzymatic activity was dispensable for gene expression.	Tetradecanoylphorbol Acetate	50-81	coactivator associated arginine methyltransferase 1	Homo sapiens	127-132
19762470-6	2009	Moreover, treatment of HeLa cells with phorbol 12-myristate 13-acetate or epidermal growth factor induced the disassociation of Sam68 from the large complex and the appearance of Sam68 within the smaller complex.	Tetradecanoylphorbol Acetate	39-70	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	128-133
19762470-6	2009	Moreover, treatment of HeLa cells with phorbol 12-myristate 13-acetate or epidermal growth factor induced the disassociation of Sam68 from the large complex and the appearance of Sam68 within the smaller complex.	Tetradecanoylphorbol Acetate	39-70	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	179-184
19563436-4	2009	Exposure to the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), enhanced TaALMT1-mediated inward currents.	Tetradecanoylphorbol Acetate	50-81	aluminum-activated malate transporter 1	Triticum aestivum	98-105
19563436-4	2009	Exposure to the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), enhanced TaALMT1-mediated inward currents.	Tetradecanoylphorbol Acetate	83-86	aluminum-activated malate transporter 1	Triticum aestivum	98-105
19840403-7	2009	PMA/ionomycin induced higher mRNA expression of CysLTR2 in B cell lines from ht2+/+ asthmatics than those from ht1+/+ asthmatics.	Tetradecanoylphorbol Acetate	0-3	cysteinyl leukotriene receptor 2	Homo sapiens	48-55
19758695-7	2009	Cyclosporin A (5 microM) and ascomycin (5 microM), inhibitors of the Ca(2+)/calmodulin-dependent protein phosphatase, calcineurin, fully restored the inhibitory effect of PMA and TMX on channel activity.	Tetradecanoylphorbol Acetate	171-174	thioredoxin related transmembrane protein 1	Homo sapiens	179-182
19691493-8	2009	When mouse erythroleukemia cells were treated with 12-O-tetradecanoyl-phorbol 13-acetate, an activator of protein kinase C, or hemin, phospho-ferrochelatase levels increased, with a concomitant decrease in zinc-insertion activity and a slight increase in iron-removal activity.	Tetradecanoylphorbol Acetate	51-88	ferrochelatase	Mus musculus	142-156
19420332-3	2009	Changes of expression of MMP-2 and MMP-9 of fibroblasts after the simulation of a standard PKC activator, 2-O-tetradecanoyl-phorbol-13-acetate (TPA), were studied.	Tetradecanoylphorbol Acetate	144-147	matrix metallopeptidase 9	Homo sapiens	35-40
19420332-7	2009	TPA stimulated the expression of MMP-2 and MMP-9 by pterygium fibroblasts isolated from early-stage specimens in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	43-48
19722655-3	2009	The BDE difference between 1 and one-electron oxidized species, [Ru(III)(dmp(-))(TPA)](2+), was determined to be 89 kcal mol(-1), which was large enough to achieve hydrogen atom transfer (HAT) from phenol derivatives.	Tetradecanoylphorbol Acetate	81-84	homeobox D13	Homo sapiens	4-7
19722655-4	2009	In the HAT reactions from phenol derivatives to [Ru(III)(dmp(-))(TPA)](2+), the second-order rate constants (k) were determined to exhibit a linear relationship with BDE values of phenol derivatives with a slope (-0.4), suggesting that this HAT is simultaneous proton and electron transfer.	Tetradecanoylphorbol Acetate	65-68	homeobox D13	Homo sapiens	166-169
19722655-5	2009	As for HAT reaction from 2,4,6-tri-tert-buthylphenol (TBP; BDE = 79.15 kcal mol(-1)) to [Ru(III)(dmp(-))(TPA)](2+), the activation parameters were determined to be DeltaH(double dagger) = 1.6 +/- 0.2 kcal mol(-1) and DeltaS(double dagger) = -36 +/- 2 cal K(-1) mol(-1).	Tetradecanoylphorbol Acetate	105-108	TATA-box binding protein	Homo sapiens	54-57
19328559-0	2009	Activation of equine neutrophils by phorbol myristate acetate or N-formyl-methionyl-leucyl-phenylalanine induces a different response in reactive oxygen species production and release of active myeloperoxidase.	Tetradecanoylphorbol Acetate	36-61	myeloperoxidase	Equus caballus	194-209
19509226-5	2009	Treatment of human adipose stromal cells with forskolin and phorbol 12-myristate 13-acetate (PMA), to mimic prostaglandin E(2), resulted in nuclear translocation of CRTC2.	Tetradecanoylphorbol Acetate	60-91	CREB regulated transcription coactivator 2	Homo sapiens	165-170
19509226-5	2009	Treatment of human adipose stromal cells with forskolin and phorbol 12-myristate 13-acetate (PMA), to mimic prostaglandin E(2), resulted in nuclear translocation of CRTC2.	Tetradecanoylphorbol Acetate	93-96	CREB regulated transcription coactivator 2	Homo sapiens	165-170
19509226-9	2009	Adiponectin treatment significantly decreased forskolin/PMA-stimulated aromatase expression, consistent with the decreased nuclear translocation of CRTC2 and the decreased binding of CRTC2 to PII.	Tetradecanoylphorbol Acetate	56-59	CREB regulated transcription coactivator 2	Homo sapiens	148-153
19447859-4	2009	Increase in the enzyme activity, protein and messenger RNA levels of matrix metalloproteinase (MMP)-9 were observed in TPA-treated HepG(2) cells, and these were blocked by pterostilbene.	Tetradecanoylphorbol Acetate	119-122	matrix metallopeptidase 9	Homo sapiens	69-101
19225867-6	2009	Activation of protein kinase C (PKC) with phorbol myristate acetate increased c-Fos and c-Jun mRNA, whereas inhibition of PKC with bisindolylmaleimide as well as inhibition of extracellular signal-regulated kinases (ERK) 1/2 with PD98059 abolished the NE-induced increase in c-Fos and c-Jun gene expression.	Tetradecanoylphorbol Acetate	42-67	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	78-83
19472186-3	2009	Treatment with both TPA and TNFalpha decreased mRNA levels of PPARgamma, aP2, LPL and adiponectin.	Tetradecanoylphorbol Acetate	20-23	transcription factor AP-2 alpha	Homo sapiens	73-76
19181503-0	2009	Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	19-22	matrix metallopeptidase 9	Homo sapiens	31-36
19181503-2	2009	Herein, we investigated the effect of silibinin, a major constituent (flavanolignan) of the fruits of Silybum marianum, on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 and VEGF expression in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	123-160	matrix metallopeptidase 9	Homo sapiens	175-180
19181503-3	2009	The expression of MMP-9 and VEGF in response to TPA was increased, whereas TPA-induced MMP-9 and VEGF expression was decreased by silibinin.	Tetradecanoylphorbol Acetate	48-51	matrix metallopeptidase 9	Homo sapiens	18-23
19181503-3	2009	The expression of MMP-9 and VEGF in response to TPA was increased, whereas TPA-induced MMP-9 and VEGF expression was decreased by silibinin.	Tetradecanoylphorbol Acetate	75-78	matrix metallopeptidase 9	Homo sapiens	87-92
19416869-4	2009	We have directly tested this hypothesis by determining the effects of dystrophin and utrophin on the microsecond rotational dynamics of a phosphorescent dye attached to C374 on actin, as detected by transient phosphorescence anisotropy (TPA).	Tetradecanoylphorbol Acetate	237-240	utrophin	Homo sapiens	85-93
19416869-5	2009	Binding of dystrophin or utrophin to actin resulted in significant changes in the TPA decay, increasing the final anisotropy (restricting the rotational amplitude) and decreasing the rotational correlation times (increasing the rotational rates and the torsional flexibility).	Tetradecanoylphorbol Acetate	82-85	utrophin	Homo sapiens	25-33
19263515-1	2009	The EL4 murine lymphoma cell line exists in variant phenotypes that differ with respect to responses to the tumor promoter phorbol 12-myristate 13-acetate (PMA1).	Tetradecanoylphorbol Acetate	123-154	epilepsy 4	Mus musculus	4-7
19130490-0	2009	Molecular mechanisms of nitric oxide-dependent inhibition of TPA-induced matrix metalloproteinase-9 (MMP-9) in MCF-7 cells.	Tetradecanoylphorbol Acetate	61-64	matrix metallopeptidase 9	Homo sapiens	73-99
19130490-0	2009	Molecular mechanisms of nitric oxide-dependent inhibition of TPA-induced matrix metalloproteinase-9 (MMP-9) in MCF-7 cells.	Tetradecanoylphorbol Acetate	61-64	matrix metallopeptidase 9	Homo sapiens	101-106
19405995-9	2009	Phorbol-12-myristate-13-acetate, a protein kinase C activator, increased EAAT3 activity.	Tetradecanoylphorbol Acetate	0-31	solute carrier family 1 member 1	Rattus norvegicus	73-78
19405995-10	2009	However, 0.64 microM amitriptyline induced a similar degree of decrease in EAAT3 activity in the presence or absence of phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	120-151	solute carrier family 1 member 1	Rattus norvegicus	75-80
18486150-11	2009	In confocal microscopy in Jurkat T cell line, phorbol 12-myristate 13-acetate (PMA) activated cPKC isoform PKCalpha after 30 min treatment and activated PKC-zeta after 60 min treatment.	Tetradecanoylphorbol Acetate	46-77	protein kinase C zeta	Homo sapiens	153-161
18486150-11	2009	In confocal microscopy in Jurkat T cell line, phorbol 12-myristate 13-acetate (PMA) activated cPKC isoform PKCalpha after 30 min treatment and activated PKC-zeta after 60 min treatment.	Tetradecanoylphorbol Acetate	79-82	protein kinase C zeta	Homo sapiens	153-161
19337254-3	2009	Treatment with TPA resulted in BCL6 degradation and cyclin D2 upregulation.	Tetradecanoylphorbol Acetate	15-18	BCL6 transcription repressor	Homo sapiens	31-35
19220020-10	2009	HEK293 cells harboring the PDP1 siRNA construct also displayed a marked decrease in the extent of PMA-initiated conversion of cellular PSDP to PSMP.	Tetradecanoylphorbol Acetate	98-101	phospholipid phosphatase 6	Homo sapiens	135-139
19133651-6	2009	Moreover, using a luciferase expression vector (pAP-1-Luc) driven by seven copies of an AP-1 cis-element, we observed that microRNA-101 expression inhibited phorbol 12-myristate 13-acetate (PMA)-induced AP-1 activity.	Tetradecanoylphorbol Acetate	157-188	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-53
19133651-6	2009	Moreover, using a luciferase expression vector (pAP-1-Luc) driven by seven copies of an AP-1 cis-element, we observed that microRNA-101 expression inhibited phorbol 12-myristate 13-acetate (PMA)-induced AP-1 activity.	Tetradecanoylphorbol Acetate	157-188	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	88-92
19133651-6	2009	Moreover, using a luciferase expression vector (pAP-1-Luc) driven by seven copies of an AP-1 cis-element, we observed that microRNA-101 expression inhibited phorbol 12-myristate 13-acetate (PMA)-induced AP-1 activity.	Tetradecanoylphorbol Acetate	190-193	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-53
19133651-6	2009	Moreover, using a luciferase expression vector (pAP-1-Luc) driven by seven copies of an AP-1 cis-element, we observed that microRNA-101 expression inhibited phorbol 12-myristate 13-acetate (PMA)-induced AP-1 activity.	Tetradecanoylphorbol Acetate	190-193	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	88-92
18843292-10	2009	Coculture with PMA-treated THP-1 macrophages induced COX-2-dependent release of matrix metalloproteinase-9 and subsequent increased invasion of BCC cells.	Tetradecanoylphorbol Acetate	15-18	matrix metallopeptidase 9	Homo sapiens	80-106
19176525-5	2009	A serine-to-alanine mutation at position 121 of ATF-2 represses the c-Jun-dependent transcription of AP-1/cyclic AMP-response element reporter genes and also the p300-mediated activation of a Gal4-reporter gene in response to TPA.	Tetradecanoylphorbol Acetate	226-229	activating transcription factor 2	Homo sapiens	48-53
19176525-5	2009	A serine-to-alanine mutation at position 121 of ATF-2 represses the c-Jun-dependent transcription of AP-1/cyclic AMP-response element reporter genes and also the p300-mediated activation of a Gal4-reporter gene in response to TPA.	Tetradecanoylphorbol Acetate	226-229	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-73
19176525-6	2009	Our results suggest that the phosphorylation of ATF-2 at Ser-121 plays a key role in the c-Jun-mediated activation of transcription that occurs in response to TPA.	Tetradecanoylphorbol Acetate	159-162	activating transcription factor 2	Homo sapiens	48-53
19176525-6	2009	Our results suggest that the phosphorylation of ATF-2 at Ser-121 plays a key role in the c-Jun-mediated activation of transcription that occurs in response to TPA.	Tetradecanoylphorbol Acetate	159-162	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-94
19164291-8	2009	Silencing of endogenous TORC2 gene expression by RNA interference decreased the levels of the BZLF1 protein in response to 12-O-tetradecanoylphorbol-13-acetate/ionophore.	Tetradecanoylphorbol Acetate	123-159	CREB regulated transcription coactivator 2	Homo sapiens	24-29
19101626-3	2009	However, a precise mechanism for C1P-induced activation of cPLA(2)alpha has not been well elucidated; such as the phosphorylation signal caused by the extracellular signal-regulated kinases (ERK1/2) pathway, a downstream of the protein kinase C activation with 4beta-phorbol myristate acetate (PMA), is required or not.	Tetradecanoylphorbol Acetate	294-297	phospholipase A2 group IVA	Homo sapiens	59-71
18816790-3	2009	2) Evoked acetylcholine (ACh) release is enhanced with the PKA agonist Sp-8-BrcAMP and the PKC agonist phorbol ester (PMA).	Tetradecanoylphorbol Acetate	118-121	protein kinase C, gamma	Rattus norvegicus	91-94
18988696-5	2009	Induction of ICOS mRNA levels by phorbol ester (PMA) plus ionomycin (Io) activation in mouse splenocytes was attenuated by Delta(9)-THC in a concentration-related manner.	Tetradecanoylphorbol Acetate	48-51	inducible T cell co-stimulator	Mus musculus	13-17
19027047-6	2009	Furthermore, non-specific and antigen-specific stimulation of CD8+ T cells by phorbol myristate acetate and MHC class I peptide-pulsed splenocytes, respectively, modulated TLR expression in purified CD4+ and CD8+ T cells.	Tetradecanoylphorbol Acetate	78-103	CD8a molecule	Homo sapiens	62-65
19027047-6	2009	Furthermore, non-specific and antigen-specific stimulation of CD8+ T cells by phorbol myristate acetate and MHC class I peptide-pulsed splenocytes, respectively, modulated TLR expression in purified CD4+ and CD8+ T cells.	Tetradecanoylphorbol Acetate	78-103	CD4 antigen	Mus musculus	199-202
19027047-6	2009	Furthermore, non-specific and antigen-specific stimulation of CD8+ T cells by phorbol myristate acetate and MHC class I peptide-pulsed splenocytes, respectively, modulated TLR expression in purified CD4+ and CD8+ T cells.	Tetradecanoylphorbol Acetate	78-103	CD8a molecule	Homo sapiens	208-211
19302552-9	2009	Association of phospho-ERK 1/2 to alpha(1B)-adrenoceptors increased not only in response to agonist but also in response to agents that increase alpha(1B)-adrenoceptor and ERK1/2 phosphorylation [such as endothelin-1, phorbol 12-myristate-13-acetate (PMA) and epidermal growth factor (EGF)]; not surprisingly, PD98059 decreased this effect.	Tetradecanoylphorbol Acetate	218-249	adrenoceptor alpha 1B	Homo sapiens	34-56
18974158-3	2009	Prior exposure of macrophages to a PKC activator, phorbol 12-myristate 13-acetate (PMA) inhibited the PI3K activation induced by the Fcgamma receptor (FcgammaR) ligation but not that induced by C5a.	Tetradecanoylphorbol Acetate	50-81	protein kinase C, delta	Mus musculus	35-38
18974158-3	2009	Prior exposure of macrophages to a PKC activator, phorbol 12-myristate 13-acetate (PMA) inhibited the PI3K activation induced by the Fcgamma receptor (FcgammaR) ligation but not that induced by C5a.	Tetradecanoylphorbol Acetate	83-86	protein kinase C, delta	Mus musculus	35-38
18835982-3	2009	Herein we demonstrate that vanillin reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 gelatinolytic activity and suppressed cell invasion through the down-regulation of MMP-9 gene transcription in HepG2 cells.	Tetradecanoylphorbol Acetate	44-80	matrix metallopeptidase 9	Homo sapiens	95-100
18835982-3	2009	Herein we demonstrate that vanillin reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 gelatinolytic activity and suppressed cell invasion through the down-regulation of MMP-9 gene transcription in HepG2 cells.	Tetradecanoylphorbol Acetate	44-80	matrix metallopeptidase 9	Homo sapiens	184-189
18835982-3	2009	Herein we demonstrate that vanillin reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 gelatinolytic activity and suppressed cell invasion through the down-regulation of MMP-9 gene transcription in HepG2 cells.	Tetradecanoylphorbol Acetate	82-85	matrix metallopeptidase 9	Homo sapiens	95-100
18835982-3	2009	Herein we demonstrate that vanillin reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 gelatinolytic activity and suppressed cell invasion through the down-regulation of MMP-9 gene transcription in HepG2 cells.	Tetradecanoylphorbol Acetate	82-85	matrix metallopeptidase 9	Homo sapiens	184-189
18835982-5	2009	Moreover, vanillin significantly suppressed the TPA-induced enzymatic activity of MMP-9 and decreased the induced mRNA level of MMP-9.	Tetradecanoylphorbol Acetate	48-51	matrix metallopeptidase 9	Homo sapiens	82-87
18835982-5	2009	Moreover, vanillin significantly suppressed the TPA-induced enzymatic activity of MMP-9 and decreased the induced mRNA level of MMP-9.	Tetradecanoylphorbol Acetate	48-51	matrix metallopeptidase 9	Homo sapiens	128-133
19418353-0	2009	Inhibitory effect of immature plum on PMA-induced MMP-9 expression in human hepatocellular carcinoma.	Tetradecanoylphorbol Acetate	38-41	matrix metallopeptidase 9	Homo sapiens	50-55
19418353-6	2009	PMA induced the translocation of c-jun and p65 to the nucleus; however, IPE inhibited their nuclear translocations induced by PMA in HepG2 cells.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	33-38
18996084-4	2008	Here we show the expression of CatE in primary human B cells and DC, which was only elevated in B cells after induction with phorbol 12-myristate 13-acetate (PMA), resulted in enhanced presentation of tetanus toxin C-fragment (TTC) to the respective T cells.	Tetradecanoylphorbol Acetate	125-156	cathepsin E	Homo sapiens	31-35
18996084-4	2008	Here we show the expression of CatE in primary human B cells and DC, which was only elevated in B cells after induction with phorbol 12-myristate 13-acetate (PMA), resulted in enhanced presentation of tetanus toxin C-fragment (TTC) to the respective T cells.	Tetradecanoylphorbol Acetate	158-161	cathepsin E	Homo sapiens	31-35
19018257-6	2008	TAM67 increased dephosphorylation of Akt induced by LY294002 and reduced the TPA response element DNA-binding of phosphorylated c-Jun.	Tetradecanoylphorbol Acetate	77-80	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	128-133
18617650-5	2008	Cyclodextrin, but not cyclodextrin/cholesterol complex, also inhibited PMA-induced CD11b activation implicating cholesterol efflux as the main mechanism.	Tetradecanoylphorbol Acetate	71-74	integrin subunit alpha M	Homo sapiens	83-88
18621736-9	2008	By using RNA interference, we demonstrate that inhibition of RACK1 expression diminishes the phorbol 12-myristate 13-acetate-dependent translocation of ADAM12 to membranes of hepatic stellate cells.	Tetradecanoylphorbol Acetate	93-124	receptor for activated C kinase 1	Homo sapiens	61-66
18496024-9	2008	CONCLUSIONS: Th2- and Th1-adjuvant activities can be quantitatively evaluated by using PMA-treated THP-1 cells and PMA-treated/forskolin-stimulated THP-1 cells, respectively.	Tetradecanoylphorbol Acetate	87-90	negative elongation factor complex member C/D	Homo sapiens	22-25
18496024-9	2008	CONCLUSIONS: Th2- and Th1-adjuvant activities can be quantitatively evaluated by using PMA-treated THP-1 cells and PMA-treated/forskolin-stimulated THP-1 cells, respectively.	Tetradecanoylphorbol Acetate	115-118	negative elongation factor complex member C/D	Homo sapiens	22-25
18063670-5	2008	IL17 (IL17A) positive T cells were identified by a flow cytometer after ex vivo stimulation with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	97-122	interleukin 17A	Homo sapiens	0-4
18063670-5	2008	IL17 (IL17A) positive T cells were identified by a flow cytometer after ex vivo stimulation with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	97-122	interleukin 17A	Homo sapiens	6-11
18628248-2	2008	Increases in the protein, messenger RNA and enzyme activity levels of matrix metalloproteinase (MMP)-9 were observed in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells, and these were blocked by QUE, but not by quercitrin or rutin.	Tetradecanoylphorbol Acetate	120-156	matrix metallopeptidase 9	Homo sapiens	70-102
18628248-2	2008	Increases in the protein, messenger RNA and enzyme activity levels of matrix metalloproteinase (MMP)-9 were observed in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells, and these were blocked by QUE, but not by quercitrin or rutin.	Tetradecanoylphorbol Acetate	158-161	matrix metallopeptidase 9	Homo sapiens	70-102
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	190-193	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	154-179
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	190-193	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	181-185
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	190-193	matrix metallopeptidase 9	Homo sapiens	228-233
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	190-193	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	389-393
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Tetradecanoylphorbol Acetate	216-219	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	181-185
18496150-7	2008	RESULTS: We discovered that the MMP-9 promoter was significantly stimulated by phorbol myristate acetate and TNF-alpha on luciferase reporter gene assays.	Tetradecanoylphorbol Acetate	79-104	matrix metallopeptidase 9	Homo sapiens	32-37
18541274-3	2008	Zinc significantly reduced IFN-gamma expression and activator protein-1 (AP-1) signaling in cells activated by phorbol 12-myristate 13-acetate (PMA) and phytohemagglutinin (PHA) without affecting cell viability.	Tetradecanoylphorbol Acetate	111-142	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-71
18541274-3	2008	Zinc significantly reduced IFN-gamma expression and activator protein-1 (AP-1) signaling in cells activated by phorbol 12-myristate 13-acetate (PMA) and phytohemagglutinin (PHA) without affecting cell viability.	Tetradecanoylphorbol Acetate	111-142	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-77
18541274-3	2008	Zinc significantly reduced IFN-gamma expression and activator protein-1 (AP-1) signaling in cells activated by phorbol 12-myristate 13-acetate (PMA) and phytohemagglutinin (PHA) without affecting cell viability.	Tetradecanoylphorbol Acetate	144-147	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-71
18541274-3	2008	Zinc significantly reduced IFN-gamma expression and activator protein-1 (AP-1) signaling in cells activated by phorbol 12-myristate 13-acetate (PMA) and phytohemagglutinin (PHA) without affecting cell viability.	Tetradecanoylphorbol Acetate	144-147	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-77
18387943-2	2008	However, recent studies indicate that PKCdelta also is dynamically regulated through tyrosine phosphorylation in H(2)O(2)- and phorbol 12-myristate 13-acetate (PMA)-treated cardiomyocytes.	Tetradecanoylphorbol Acetate	127-158	protein kinase C, delta	Mus musculus	38-46
18387943-2	2008	However, recent studies indicate that PKCdelta also is dynamically regulated through tyrosine phosphorylation in H(2)O(2)- and phorbol 12-myristate 13-acetate (PMA)-treated cardiomyocytes.	Tetradecanoylphorbol Acetate	160-163	protein kinase C, delta	Mus musculus	38-46
18400024-2	2008	MATERIALS AND METHODS: Effect of PBP pre-treatments on 12-O-tetradecanoylphorbol-13-acetate (TPA) promoted skin papillomas was studied in 7,12-dimethylbenz(a)anthracene initiated mice over 40 weeks.	Tetradecanoylphorbol Acetate	55-91	phosphatidylethanolamine binding protein 1	Mus musculus	33-36
18400024-2	2008	MATERIALS AND METHODS: Effect of PBP pre-treatments on 12-O-tetradecanoylphorbol-13-acetate (TPA) promoted skin papillomas was studied in 7,12-dimethylbenz(a)anthracene initiated mice over 40 weeks.	Tetradecanoylphorbol Acetate	93-96	phosphatidylethanolamine binding protein 1	Mus musculus	33-36
18400024-6	2008	Most PBP fractions decreased TPA-induced cell proliferation by decreasing activation of signalling kinases (c-Jun N-terminal protein kinase, extracellular signal-regulated protein kinase, p38 protein kinase and Akt), transcription factors (activator protein-1 and nuclear factor kappa B) and inflammatory protein (cyclooxygenase 2).	Tetradecanoylphorbol Acetate	29-32	phosphatidylethanolamine binding protein 1	Mus musculus	5-8
18400024-7	2008	TPA-induced epidermal cell apoptosis was also decreased by pre-treatment with most PBP fractions.	Tetradecanoylphorbol Acetate	0-3	phosphatidylethanolamine binding protein 1	Mus musculus	83-86
18400024-8	2008	Higher levels of p53 and p21 in skin cells pre-treated with PBP fractions followed by TPA treatment as compared to only TPA-treated animals suggested possible activation of a cell cycle checkpoint.	Tetradecanoylphorbol Acetate	86-89	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	25-28
18400024-8	2008	Higher levels of p53 and p21 in skin cells pre-treated with PBP fractions followed by TPA treatment as compared to only TPA-treated animals suggested possible activation of a cell cycle checkpoint.	Tetradecanoylphorbol Acetate	120-123	phosphatidylethanolamine binding protein 1	Mus musculus	60-63
18400024-10	2008	In conclusion, the protective effects of PBP fractions could be attributed to inhibition of TPA-induced cellular proliferation.	Tetradecanoylphorbol Acetate	92-95	phosphatidylethanolamine binding protein 1	Mus musculus	41-44
19031740-6	2008	Surface antigen Gp IIb-IIIa (CD41) of knock-down cells treated with phorbol 12-myristate 13-acetate was analyzed by flow cytometry.	Tetradecanoylphorbol Acetate	68-99	integrin subunit alpha 2b	Homo sapiens	29-33
19704116-5	2009	However, phorbol 12-myristate 13-acetate and ionomycin stimulation or conjugation to susceptible target cells induced myosin-dependent colocalization of Rab27a and Munc13-4 with perforin.	Tetradecanoylphorbol Acetate	9-40	RAB27A, member RAS oncogene family	Homo sapiens	153-159
19887187-5	2009	In phorbol myristate acetate-differentiated THP-1 macrophages, pressure stimulated beta(1)-integrin T788/789 phosphorylation, but not S785 phosphorylation.	Tetradecanoylphorbol Acetate	3-28	integrin subunit beta 1	Homo sapiens	83-99
19828892-3	2009	We tested the hypothesis that cPLA(2)alpha also regulates MMP-9 induction by Fusobacterium nucleatum and by phorbol 12-myristate-13-acetate (PMA) in gingival epithelial cells.	Tetradecanoylphorbol Acetate	108-139	phospholipase A2 group IVA	Homo sapiens	30-42
19828892-3	2009	We tested the hypothesis that cPLA(2)alpha also regulates MMP-9 induction by Fusobacterium nucleatum and by phorbol 12-myristate-13-acetate (PMA) in gingival epithelial cells.	Tetradecanoylphorbol Acetate	108-139	matrix metallopeptidase 9	Homo sapiens	58-63
19959889-3	2009	TPA-treated cells became blast-cell-like and had high expressions of cyclin D, cyclin B and PCNA.	Tetradecanoylphorbol Acetate	0-3	proliferating cell nuclear antigen	Canis lupus familiaris	92-96
19590902-8	2009	Significant decrease in the incidence of CRB was observed when prophylactic TPA/tobra ABL was used in the high-risk group (P = 0.0201).	Tetradecanoylphorbol Acetate	76-79	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	86-89
19590902-11	2009	However, both the overall and infection-free survival of the catheters in the high-risk group significantly improved while the patients were receiving TPA/tobra ABL prophylaxis, becoming similar to the outcomes of the catheters in the average-risk group and exhibiting statistically non-significant differences (P = 0.5571 and P = 0.9711, respectively).	Tetradecanoylphorbol Acetate	151-154	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	161-164
19687351-6	2009	In addition, EXP3179 inhibited (P&lt;0.05) both phorbol myristate acetate-stimulated p47phox translocation from cytosol to membranes and protein kinase C activity.	Tetradecanoylphorbol Acetate	48-73	neutrophil cytosolic factor 1	Homo sapiens	85-92
19687351-8	2009	EXP3179 also inhibited (P&lt;0.05) phorbol myristate acetate-stimulated MMP-9 secretion.	Tetradecanoylphorbol Acetate	35-60	matrix metallopeptidase 9	Homo sapiens	72-77
19564157-4	2009	Here, we report that PAD2 is expressed in human monocytic leukaemia THP-1 cells during differentiation into macrophages by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	123-159	peptidyl arginine deiminase 2	Homo sapiens	21-25
19633291-2	2009	Here we demonstrate that 12-O-tetradecanoylphorbol-13-acetate (TPA) induces TBX2 expression in normal human fibroblasts in a protein kinase C (PKC)-dependent and MAPK-independent manner.	Tetradecanoylphorbol Acetate	25-61	T-box transcription factor 2	Homo sapiens	76-80
19633291-2	2009	Here we demonstrate that 12-O-tetradecanoylphorbol-13-acetate (TPA) induces TBX2 expression in normal human fibroblasts in a protein kinase C (PKC)-dependent and MAPK-independent manner.	Tetradecanoylphorbol Acetate	63-66	T-box transcription factor 2	Homo sapiens	76-80
19633291-3	2009	Our data further reveal that TPA activates transcription of TBX2 through activating MSK1, which leads to an increase in phosphorylated histone H3 and the recruitment of Sp1 to the TBX2 gene.	Tetradecanoylphorbol Acetate	29-32	T-box transcription factor 2	Homo sapiens	60-64
19633291-3	2009	Our data further reveal that TPA activates transcription of TBX2 through activating MSK1, which leads to an increase in phosphorylated histone H3 and the recruitment of Sp1 to the TBX2 gene.	Tetradecanoylphorbol Acetate	29-32	T-box transcription factor 2	Homo sapiens	180-184
19725963-3	2009	We identified a high incidence region (HIR) of vector integration using PCR techniques in the upstream region close to the LMO2 transcription start site in the TPA-Mat T cell line.	Tetradecanoylphorbol Acetate	160-163	LIM domain only 2	Homo sapiens	123-127
19571234-4	2009	The present studies were, therefore, undertaken to investigate ASBT regulation in intestinal Caco-2 monolayers by the well-known PKC activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	143-174	solute carrier family 10 member 2	Homo sapiens	63-67
19571234-4	2009	The present studies were, therefore, undertaken to investigate ASBT regulation in intestinal Caco-2 monolayers by the well-known PKC activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	143-174	protein kinase C zeta	Homo sapiens	129-132
19571234-4	2009	The present studies were, therefore, undertaken to investigate ASBT regulation in intestinal Caco-2 monolayers by the well-known PKC activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	176-179	solute carrier family 10 member 2	Homo sapiens	63-67
19571234-4	2009	The present studies were, therefore, undertaken to investigate ASBT regulation in intestinal Caco-2 monolayers by the well-known PKC activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	176-179	protein kinase C zeta	Homo sapiens	129-132
19571234-6	2009	The inhibitory effect of PMA was blocked in the presence of 5 microM bisindolylmaleimide I (PKC inhibitor) but not 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-AM (Ca(2+) chelator) or LY-294002 (phosphatidylinositol 3-kinase inhibitor).	Tetradecanoylphorbol Acetate	25-28	protein kinase C zeta	Homo sapiens	92-95
19470390-7	2009	Pretreatment of farnesol significantly decreased TPA-induced ornithine decarboxylase (ODC) activity and [(3)H]thymidine incorporation in dose-dependent manner.	Tetradecanoylphorbol Acetate	49-52	ornithine decarboxylase, structural 1	Mus musculus	61-84
19470390-7	2009	Pretreatment of farnesol significantly decreased TPA-induced ornithine decarboxylase (ODC) activity and [(3)H]thymidine incorporation in dose-dependent manner.	Tetradecanoylphorbol Acetate	49-52	ornithine decarboxylase, structural 1	Mus musculus	86-89
18355442-4	2008	B428 inhibited basal and PMA-induced active MMP-9 in glioblastomas (GBM) U1242 cell media as well as cell invasion in vitro.	Tetradecanoylphorbol Acetate	25-28	matrix metallopeptidase 9	Homo sapiens	44-49
1450403-4	1992	We showed that IL-4R mRNA accumulation in human T cells is enhanced fourfold after activation of different secondary signaling pathways by concanavalin A (Con A), phorbol myristate acetate (PMA), the calcium ionophore A23187, and combinations of these factors.	Tetradecanoylphorbol Acetate	190-193	interleukin 4 receptor	Homo sapiens	15-20
19427336-7	2009	Re-expression study reveals that the shorter isoform of Aiolos (Aio-2) controls PMA/ionomycin-mediated apoptosis via up-regulation and down-regulation of the PKCdelta and bak genes, respectively.	Tetradecanoylphorbol Acetate	80-83	IKAROS family zinc finger 3	Gallus gallus	56-62
19420016-7	2009	Treatment with the protein kinase C (PKC)delta inhibitor rottlerin caused a marked decrease in PMA-induced MMP-9 secretion and cell invasion, as well as ERK/AP-1 activation, and KPS-A reduced PMA-induced membrane localization of PKCdelta.	Tetradecanoylphorbol Acetate	95-98	matrix metallopeptidase 9	Homo sapiens	107-112
1467836-8	1992	TPA (1 microM) significantly attenuated the peak Ins(1,4,5)P3 response to bradykinin and histamine by 30% and 70% respectively.	Tetradecanoylphorbol Acetate	0-3	kininogen 1	Bos taurus	74-84
19420016-9	2009	These results suggest that KPS-A inhibits PMA-induced invasion by reducing MMP-9 activation, mainly via the PI3K/Akt/NF-kappaB and PKCdelta/ERK/AP-1 pathways in MCF-7 cells and blocks tumor growth and MMP-9-mediated invasiveness in mice with breast carcinoma.	Tetradecanoylphorbol Acetate	42-45	matrix metallopeptidase 9	Homo sapiens	75-80
19420016-9	2009	These results suggest that KPS-A inhibits PMA-induced invasion by reducing MMP-9 activation, mainly via the PI3K/Akt/NF-kappaB and PKCdelta/ERK/AP-1 pathways in MCF-7 cells and blocks tumor growth and MMP-9-mediated invasiveness in mice with breast carcinoma.	Tetradecanoylphorbol Acetate	42-45	matrix metallopeptidase 9	Homo sapiens	201-206
19542437-5	2009	Splenic iNKT cells produced IL-27p28 in the culture supernatant upon stimulation with PMA plus ionomycin, although the transcript of IL-27p28 in the iNKT cells was constitutively expressed regardless of the stimulation.	Tetradecanoylphorbol Acetate	86-89	interleukin 27	Mus musculus	28-36
18194441-3	2008	In this study, we examine in vitro whether ACBP is secreted by Muller glial cells and Muller-like QNR/K2 cells following stimulation with elevated levels of KCl and phorbol myristic acetate (PMA).	Tetradecanoylphorbol Acetate	191-194	acyl-CoA-binding protein	Oryctolagus cuniculus	43-47
18194441-4	2008	KCl and PMA stimulation evoked secretion of threonine-phosphorylated ACBP.	Tetradecanoylphorbol Acetate	8-11	acyl-CoA-binding protein	Oryctolagus cuniculus	69-73
18194441-8	2008	As CK2 is not expressed in QNR/K2 cells, it is probable that protein kinase C accounts for the phosphorylation of ACBP in these cells and for the PMA-evoked secretion of ACBP.	Tetradecanoylphorbol Acetate	146-149	acyl-CoA-binding protein	Oryctolagus cuniculus	170-174
18483307-2	2008	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) enzyme activity and gene expression at both protein and mRNA levels were examined in human breast carcinoma cells (MCF-7 and MDA-MB-231), and the addition of the MMP-9 inhibitor, SB3CT, significantly suppressed TPA-induced invasion and migration according to the in vitro Transwell assay.	Tetradecanoylphorbol Acetate	0-36	matrix metallopeptidase 9	Homo sapiens	51-77
19542437-6	2009	By contrast, the transcript of IL-27EBI3 was induced in the iNKT cells upon stimulation with PMA plus ionomycin in vitro and with alpha-GalCer treatment in vivo, suggesting that IL-27 (p28/EBI3) could be produced by iNKT cells in an activation-dependent manner.	Tetradecanoylphorbol Acetate	93-96	interleukin 27	Mus musculus	31-36
19542437-6	2009	By contrast, the transcript of IL-27EBI3 was induced in the iNKT cells upon stimulation with PMA plus ionomycin in vitro and with alpha-GalCer treatment in vivo, suggesting that IL-27 (p28/EBI3) could be produced by iNKT cells in an activation-dependent manner.	Tetradecanoylphorbol Acetate	93-96	Epstein-Barr virus induced gene 3	Mus musculus	36-40
18483307-2	2008	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) enzyme activity and gene expression at both protein and mRNA levels were examined in human breast carcinoma cells (MCF-7 and MDA-MB-231), and the addition of the MMP-9 inhibitor, SB3CT, significantly suppressed TPA-induced invasion and migration according to the in vitro Transwell assay.	Tetradecanoylphorbol Acetate	0-36	matrix metallopeptidase 9	Homo sapiens	79-84
1338729-10	1992	Analogous effects were observed with TPA which minimally stimulated c-fos and c-jun mRNAs on day 0, but markedly increased these messages on day 2.	Tetradecanoylphorbol Acetate	37-40	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	68-73
18483307-2	2008	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) enzyme activity and gene expression at both protein and mRNA levels were examined in human breast carcinoma cells (MCF-7 and MDA-MB-231), and the addition of the MMP-9 inhibitor, SB3CT, significantly suppressed TPA-induced invasion and migration according to the in vitro Transwell assay.	Tetradecanoylphorbol Acetate	0-36	matrix metallopeptidase 9	Homo sapiens	248-253
18483307-2	2008	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) enzyme activity and gene expression at both protein and mRNA levels were examined in human breast carcinoma cells (MCF-7 and MDA-MB-231), and the addition of the MMP-9 inhibitor, SB3CT, significantly suppressed TPA-induced invasion and migration according to the in vitro Transwell assay.	Tetradecanoylphorbol Acetate	38-41	matrix metallopeptidase 9	Homo sapiens	51-77
18483307-2	2008	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) enzyme activity and gene expression at both protein and mRNA levels were examined in human breast carcinoma cells (MCF-7 and MDA-MB-231), and the addition of the MMP-9 inhibitor, SB3CT, significantly suppressed TPA-induced invasion and migration according to the in vitro Transwell assay.	Tetradecanoylphorbol Acetate	38-41	matrix metallopeptidase 9	Homo sapiens	79-84
18483307-2	2008	12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) enzyme activity and gene expression at both protein and mRNA levels were examined in human breast carcinoma cells (MCF-7 and MDA-MB-231), and the addition of the MMP-9 inhibitor, SB3CT, significantly suppressed TPA-induced invasion and migration according to the in vitro Transwell assay.	Tetradecanoylphorbol Acetate	38-41	matrix metallopeptidase 9	Homo sapiens	248-253
19737478-1	2009	AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF).	Tetradecanoylphorbol Acetate	113-144	interleukin 18	Homo sapiens	70-84
19737478-1	2009	AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF).	Tetradecanoylphorbol Acetate	113-144	interleukin 18	Homo sapiens	86-91
19737478-1	2009	AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF).	Tetradecanoylphorbol Acetate	146-149	interleukin 18	Homo sapiens	70-84
1335598-4	1992	20 minute treatment with TGF-b1 (8 ng/ml), forskolin (30 microM), and TPA (200 nM) all caused an increase in MARCKS phosphorylation as quantified by densitometric scanning.	Tetradecanoylphorbol Acetate	70-73	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	109-115
19737478-1	2009	AIM: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF).	Tetradecanoylphorbol Acetate	146-149	interleukin 18	Homo sapiens	86-91
18211802-5	2008	Stimulation of HeLa S3 cells with 12-O-tetradecanoyl-phorbol-13-acetate induced the phosphorylation of GEF-H1 in an ERK-dependent manner.	Tetradecanoylphorbol Acetate	34-71	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	103-109
1280433-3	1992	Phorbol myristate acetate (PMA) and thrombin increased the expression of PDGF B-chain gene to 19.8 +/- 1.75 and 15.9 +/- 1.84 fold (n = 3) of the control without affecting beta-receptor gene expression.	Tetradecanoylphorbol Acetate	0-25	platelet derived growth factor subunit B	Homo sapiens	73-85
17891173-5	2008	In this study, we examined the role of Rab13 and JRAB/MICAL-L2 in the scattering of Madin-Darby canine kidney (MDCK) cells in response to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	138-174	MICAL-like 2	Mus musculus	49-53
17891173-6	2008	Knockdown of Rab13 in canine MDCK cells suppressed the TPA-induced scattering, and this phenotype was restored by re-expression of human Rab13.	Tetradecanoylphorbol Acetate	55-58	RAB13, member RAS oncogene family	Homo sapiens	137-142
17891173-7	2008	During TPA-induced MDCK cell scattering, Rab13 was transiently activated and returned to its basal level, and both Rab13 and JRAB/MICAL-L2 were colocalized with F-actin at cell-cell contact sites and then accumulated at emerging lamellipodial structures.	Tetradecanoylphorbol Acetate	7-10	MICAL-like 2	Mus musculus	125-129
17891173-8	2008	TPA-induced MDCK cell scattering was also inhibited by knockdown of canine JRAB/MICAL-L2 and rescued by re-expression of mouse JRAB/MICAL-L2.	Tetradecanoylphorbol Acetate	0-3	MICAL-like 2	Mus musculus	75-79
17891173-8	2008	TPA-induced MDCK cell scattering was also inhibited by knockdown of canine JRAB/MICAL-L2 and rescued by re-expression of mouse JRAB/MICAL-L2.	Tetradecanoylphorbol Acetate	0-3	MICAL-like 2	Mus musculus	127-131
17891173-8	2008	TPA-induced MDCK cell scattering was also inhibited by knockdown of canine JRAB/MICAL-L2 and rescued by re-expression of mouse JRAB/MICAL-L2.	Tetradecanoylphorbol Acetate	0-3	MICAL-like 2	Mus musculus	132-140
19379723-7	2009	As immunostaining analysis revealed that PDE7A is expressed in the epidermis and TNF-alpha is known to contribute to the TPA-induced edema, it is possible that the inhibitory effect of ASB16165 on skin edema in mouse TPA-induced dermatitis model is mediated by suppression of TNF-alpha production.	Tetradecanoylphorbol Acetate	217-220	phosphodiesterase 7A	Mus musculus	41-46
1280433-3	1992	Phorbol myristate acetate (PMA) and thrombin increased the expression of PDGF B-chain gene to 19.8 +/- 1.75 and 15.9 +/- 1.84 fold (n = 3) of the control without affecting beta-receptor gene expression.	Tetradecanoylphorbol Acetate	27-30	platelet derived growth factor subunit B	Homo sapiens	73-85
19422227-4	2009	Phorbol-12-myristate-13-acetate (PMA)-induced invasion and matrix metalloproteinase (MMP)-9 expression levels of HepG2 cells were reduced by GLE treatment in a dose-dependent manner.	Tetradecanoylphorbol Acetate	33-36	matrix metallopeptidase 9	Homo sapiens	59-91
1332032-5	1992	We report here that O2- production was partly restored to phorbol 12-myristate 13-acetate-stimulated Epstein-Barr virus-transformed B lymphocytes from a patient with p47phox-deficient chronic granulomatous disease by transfection with an expression plasmid containing a p47phox cDNA inserted in the sense direction.	Tetradecanoylphorbol Acetate	58-89	neutrophil cytosolic factor 1	Homo sapiens	166-173
19235605-4	2009	Cell treatment with phorbol 12-myristate 13-acetate (PMA) plus ionomycin or the CD3 mAb OKT3 plus intercellular cell adhesion molecule-1 (ICAM-1) at 37 degrees C for 6 h induced a dramatic increase in CD25, CD69 and MEM148 epitope exposure.	Tetradecanoylphorbol Acetate	20-51	interleukin 2 receptor, alpha chain	Mus musculus	201-205
18174170-3	2008	Moreover, NIH3T3 cells expressing the 4 CRUs of Ahnak showed enhanced c-Raf, MEK, and Erk phosphorylation in response to phorbol 12-myristate 13-acetate (PMA) compared with parental cells.	Tetradecanoylphorbol Acetate	121-152	v-raf-leukemia viral oncogene 1	Mus musculus	70-75
18174170-3	2008	Moreover, NIH3T3 cells expressing the 4 CRUs of Ahnak showed enhanced c-Raf, MEK, and Erk phosphorylation in response to phorbol 12-myristate 13-acetate (PMA) compared with parental cells.	Tetradecanoylphorbol Acetate	154-157	v-raf-leukemia viral oncogene 1	Mus musculus	70-75
1357985-8	1992	PMA treatment results in ICAM-1 protein induction that declines to basal levels by 3 days.	Tetradecanoylphorbol Acetate	0-3	intercellular adhesion molecule 1	Homo sapiens	25-31
18205225-7	2008	Exposure to HIV-1 Tat protein (1,000 ng/ml) increased HTLV-1 p19 expression almost twofold by 48 hr, and cells co-stimulated with 10 nM phorbol myristate acetate (PMA) showed almost a fourfold increase over baseline.	Tetradecanoylphorbol Acetate	136-161	Tat	Human immunodeficiency virus 1	18-21
18205225-7	2008	Exposure to HIV-1 Tat protein (1,000 ng/ml) increased HTLV-1 p19 expression almost twofold by 48 hr, and cells co-stimulated with 10 nM phorbol myristate acetate (PMA) showed almost a fourfold increase over baseline.	Tetradecanoylphorbol Acetate	163-166	Tat	Human immunodeficiency virus 1	18-21
19679626-8	2009	Zymography revealed MMP-2 and phorbol 12-myristate 13-acetate-induced MMP-9 secretion.	Tetradecanoylphorbol Acetate	30-61	matrix metallopeptidase 9	Homo sapiens	70-75
11537644-10	1992	Furthermore, both under clinostatting and real microgravity, EGF- and TPA-induced c-fos expression is decreased, while forskolin and A23187-induced c-fos expression remains unaltered.	Tetradecanoylphorbol Acetate	70-73	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-87
19181503-4	2009	To investigate the regulatory mechanism of silibinin on TPA-induced MMP-9 and VEGF expression, we pretreated cells with various inhibitors, such as UO126 (MEK1/2 inhibitor), SP600125 (JNK inhibitor), and SB203580 (p38 inhibitor).	Tetradecanoylphorbol Acetate	56-59	matrix metallopeptidase 9	Homo sapiens	68-73
19181503-5	2009	Interestingly, TPA-induced MMP-9 expression was significantly inhibited by UO126, but not by SP600125 and SB203580.	Tetradecanoylphorbol Acetate	15-18	matrix metallopeptidase 9	Homo sapiens	27-32
19181503-10	2009	Taken together, we suggest that the inhibition of TPA-induced MMP-9 and VEGF expression by silibinin is mediated by the suppression of the Raf/MEK/ERK pathway in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	50-53	matrix metallopeptidase 9	Homo sapiens	62-67
18048355-4	2008	Here, we show that Kidins220, which is a substrate of PKD proteins in neuroendocrine cells, is localized in the ends of the processes of BON cells, similar to the expression pattern of NT vesicles, and translocates to the membrane and large vesicle-like structures formed in response to phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	287-318	protein kinase D1	Homo sapiens	54-57
18024477-9	2008	In conclusion, we demonstrated that the anti-invasive effects of the LAB on the PMA-induced HepG(2) cells might be through inhibiting the phosphorylation of ERK1/2 and reducing AP-1 and NF-kappaB DNA-binding activities, leading to downregulation of MMP-9 expression.	Tetradecanoylphorbol Acetate	80-83	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	177-181
19375915-5	2009	Apparently, phorbol myristate acetate (PMA) stimulated expressions of ERK, JNK and p38 were altered in the presence of potent tumour inducer, phorbol myristate acetate QAGlc, suggesting their suppression also contributes to QAGlc-mediated inhibition of MMP-9 and MMP-2.	Tetradecanoylphorbol Acetate	12-37	matrix metallopeptidase 9	Homo sapiens	253-258
1445798-5	1992	Although the levels of other fos-related mRNAs were also elevated, their maximal induction was delayed by approximately 5 h. IL-1 alone had little or no effect, but enhanced TPA induced transcription and steady-state levels of these mRNAs.	Tetradecanoylphorbol Acetate	174-177	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-32
19375915-5	2009	Apparently, phorbol myristate acetate (PMA) stimulated expressions of ERK, JNK and p38 were altered in the presence of potent tumour inducer, phorbol myristate acetate QAGlc, suggesting their suppression also contributes to QAGlc-mediated inhibition of MMP-9 and MMP-2.	Tetradecanoylphorbol Acetate	39-42	matrix metallopeptidase 9	Homo sapiens	253-258
19375915-5	2009	Apparently, phorbol myristate acetate (PMA) stimulated expressions of ERK, JNK and p38 were altered in the presence of potent tumour inducer, phorbol myristate acetate QAGlc, suggesting their suppression also contributes to QAGlc-mediated inhibition of MMP-9 and MMP-2.	Tetradecanoylphorbol Acetate	142-167	matrix metallopeptidase 9	Homo sapiens	253-258
1445798-6	1992	The expression of fos and jun during T-cell activation was accompanied by increased specific binding of JunB, FosB, and fos-related antigen containing complexes to the TPA responsive element.	Tetradecanoylphorbol Acetate	168-171	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-21
19168130-7	2009	Treatment with doxycycline/TPA or TPA alone increased phosphorylations of Elk-1(S383), PDK1(S241), Rb(S807/S811), PKCdelta(T505), p38MAPK(T180/Y182), MEK1/2(S217/S221) and ERK2(T185/T187).	Tetradecanoylphorbol Acetate	27-30	ETS transcription factor ELK1	Homo sapiens	74-79
18024477-9	2008	In conclusion, we demonstrated that the anti-invasive effects of the LAB on the PMA-induced HepG(2) cells might be through inhibiting the phosphorylation of ERK1/2 and reducing AP-1 and NF-kappaB DNA-binding activities, leading to downregulation of MMP-9 expression.	Tetradecanoylphorbol Acetate	80-83	matrix metallopeptidase 9	Homo sapiens	249-254
1445798-6	1992	The expression of fos and jun during T-cell activation was accompanied by increased specific binding of JunB, FosB, and fos-related antigen containing complexes to the TPA responsive element.	Tetradecanoylphorbol Acetate	168-171	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-123
19168130-7	2009	Treatment with doxycycline/TPA or TPA alone increased phosphorylations of Elk-1(S383), PDK1(S241), Rb(S807/S811), PKCdelta(T505), p38MAPK(T180/Y182), MEK1/2(S217/S221) and ERK2(T185/T187).	Tetradecanoylphorbol Acetate	27-30	pyruvate dehydrogenase kinase 1	Homo sapiens	87-91
19168130-7	2009	Treatment with doxycycline/TPA or TPA alone increased phosphorylations of Elk-1(S383), PDK1(S241), Rb(S807/S811), PKCdelta(T505), p38MAPK(T180/Y182), MEK1/2(S217/S221) and ERK2(T185/T187).	Tetradecanoylphorbol Acetate	34-37	ETS transcription factor ELK1	Homo sapiens	74-79
1396338-13	1992	A similar activation of PKC was achieved with 100 nM TPA.	Tetradecanoylphorbol Acetate	53-56	protein kinase C, gamma	Rattus norvegicus	24-27
19168130-7	2009	Treatment with doxycycline/TPA or TPA alone increased phosphorylations of Elk-1(S383), PDK1(S241), Rb(S807/S811), PKCdelta(T505), p38MAPK(T180/Y182), MEK1/2(S217/S221) and ERK2(T185/T187).	Tetradecanoylphorbol Acetate	34-37	pyruvate dehydrogenase kinase 1	Homo sapiens	87-91
18197392-0	2008	hnRNP-R regulates the PMA-induced c-fos expression in retinal cells.	Tetradecanoylphorbol Acetate	22-25	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	34-39
19130490-2	2009	We investigated the modulatory effects of nitric oxide (NO) on the 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced MMP-9 expression in MCF-7 cells.	Tetradecanoylphorbol Acetate	67-103	matrix metallopeptidase 9	Homo sapiens	118-123
1396338-16	1992	In a second experiment, the mitogenic effect of IGF-I was partially abolished in cells depleted of PKC by preincubation with high concentrations of TPA (300 nM).	Tetradecanoylphorbol Acetate	148-151	protein kinase C, gamma	Rattus norvegicus	99-102
19130490-2	2009	We investigated the modulatory effects of nitric oxide (NO) on the 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced MMP-9 expression in MCF-7 cells.	Tetradecanoylphorbol Acetate	105-108	matrix metallopeptidase 9	Homo sapiens	118-123
18234971-11	2008	Our results show that JNK1-associated COX-2 induction is implicated in TPA-associated cell transformation and cell cycle progression.	Tetradecanoylphorbol Acetate	71-74	mitogen-activated protein kinase 8	Mus musculus	22-26
19130490-3	2009	Different chemical NO donors inhibited the extracellular content of TPA-induced MMP-9 protein and MMP-9 activity as assessed by gelatin-zymography and ELISA, respectively.	Tetradecanoylphorbol Acetate	68-71	matrix metallopeptidase 9	Homo sapiens	80-85
1396338-17	1992	Finally, incubation of astrocytes with the PKC inhibitor H-7 at 20 microM, a concentration that completely blocked the mitogenic action of TPA, only reduced the ability of IGF-I to stimulate DNA synthesis by 50%.	Tetradecanoylphorbol Acetate	139-142	protein kinase C, gamma	Rattus norvegicus	43-46
19130490-3	2009	Different chemical NO donors inhibited the extracellular content of TPA-induced MMP-9 protein and MMP-9 activity as assessed by gelatin-zymography and ELISA, respectively.	Tetradecanoylphorbol Acetate	68-71	matrix metallopeptidase 9	Homo sapiens	98-103
19130490-6	2009	Electrophoretic mobility shift assays (EMSA), showed that NO specifically interferes with the TPA-induced DNA binding affinity of c-Jun and c-Fos without affecting the TPA-induced increase in the levels of the transcription factors.	Tetradecanoylphorbol Acetate	94-97	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-135
1426027-1	1992	12-O-Tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C (PKC), induced ornithine decarboxylase (ODC) in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	0-36	ornithine decarboxylase, structural 1	Mus musculus	92-115
19130490-6	2009	Electrophoretic mobility shift assays (EMSA), showed that NO specifically interferes with the TPA-induced DNA binding affinity of c-Jun and c-Fos without affecting the TPA-induced increase in the levels of the transcription factors.	Tetradecanoylphorbol Acetate	94-97	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-145
19130490-7	2009	Using pharmacological inhibitors and small interfering (si)RNA we found that PKCdelta is indispensably involved in the TPA-triggered MMP-9 expression.	Tetradecanoylphorbol Acetate	119-122	matrix metallopeptidase 9	Homo sapiens	133-138
19130490-8	2009	Concomitantly, the TPA-evoked increase in total PKC activity was strongly attenuated in the lysates from NO-treated MCF-7 cells, thus suggesting that NO attenuates TPA-triggered MMP-9 mainly through a direct inhibition of PKCdelta.	Tetradecanoylphorbol Acetate	19-22	matrix metallopeptidase 9	Homo sapiens	178-183
19130490-8	2009	Concomitantly, the TPA-evoked increase in total PKC activity was strongly attenuated in the lysates from NO-treated MCF-7 cells, thus suggesting that NO attenuates TPA-triggered MMP-9 mainly through a direct inhibition of PKCdelta.	Tetradecanoylphorbol Acetate	164-167	matrix metallopeptidase 9	Homo sapiens	178-183
19289499-5	2009	The newly identified kappaB site in the BECN1 promoter specifically interacts with p65 both in vitro and in living Jurkat cells upon phorbol myristate acetate (PMA)-ionomycin stimulation, where p65 induction is coupled to BECN1 upregulation and autophagy induction.	Tetradecanoylphorbol Acetate	133-158	beclin 1	Homo sapiens	40-45
19289499-5	2009	The newly identified kappaB site in the BECN1 promoter specifically interacts with p65 both in vitro and in living Jurkat cells upon phorbol myristate acetate (PMA)-ionomycin stimulation, where p65 induction is coupled to BECN1 upregulation and autophagy induction.	Tetradecanoylphorbol Acetate	160-163	beclin 1	Homo sapiens	40-45
19289499-5	2009	The newly identified kappaB site in the BECN1 promoter specifically interacts with p65 both in vitro and in living Jurkat cells upon phorbol myristate acetate (PMA)-ionomycin stimulation, where p65 induction is coupled to BECN1 upregulation and autophagy induction.	Tetradecanoylphorbol Acetate	160-163	beclin 1	Homo sapiens	222-227
18050249-6	2007	Activation-induced shedding of CD16 was investigated by treating blood samples with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	84-109	Fc gamma receptor IIIa	Homo sapiens	31-35
18056199-2	2007	In this study, we investigated whether synthetic induction of c-Fos/AP-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) converts the phenotype of TRAIL-resistant prostate cancer cells to a TRAIL-sensitive phenotype in vitro and in vivo.	Tetradecanoylphorbol Acetate	76-112	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	62-67
18056199-2	2007	In this study, we investigated whether synthetic induction of c-Fos/AP-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) converts the phenotype of TRAIL-resistant prostate cancer cells to a TRAIL-sensitive phenotype in vitro and in vivo.	Tetradecanoylphorbol Acetate	76-112	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-72
18056199-2	2007	In this study, we investigated whether synthetic induction of c-Fos/AP-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) converts the phenotype of TRAIL-resistant prostate cancer cells to a TRAIL-sensitive phenotype in vitro and in vivo.	Tetradecanoylphorbol Acetate	114-117	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	62-67
1426027-1	1992	12-O-Tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C (PKC), induced ornithine decarboxylase (ODC) in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	0-36	ornithine decarboxylase, structural 1	Mus musculus	117-120
1426027-1	1992	12-O-Tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C (PKC), induced ornithine decarboxylase (ODC) in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	38-41	ornithine decarboxylase, structural 1	Mus musculus	92-115
1426027-1	1992	12-O-Tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C (PKC), induced ornithine decarboxylase (ODC) in primary cultured mouse epidermal cells.	Tetradecanoylphorbol Acetate	38-41	ornithine decarboxylase, structural 1	Mus musculus	117-120
18056199-2	2007	In this study, we investigated whether synthetic induction of c-Fos/AP-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) converts the phenotype of TRAIL-resistant prostate cancer cells to a TRAIL-sensitive phenotype in vitro and in vivo.	Tetradecanoylphorbol Acetate	114-117	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-72
18802750-2	2009	Our previous study showed the effect of phorbol 12-myristate 13-acetate (PMA), a PKC activator, inducing a decrease in retinal cells proliferation.	Tetradecanoylphorbol Acetate	40-71	protein kinase C, gamma	Rattus norvegicus	81-84
18056199-5	2007	RESULTS: We show that the combination of TRAIL with low-dose TPA has no effect on nonmalignant prostate epithelial cells; however, TPA up-regulates most AP-1 proteins and AP-1 activity, reduces c-FLIP(L), and potentiates TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	131-134	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	153-157
18802750-2	2009	Our previous study showed the effect of phorbol 12-myristate 13-acetate (PMA), a PKC activator, inducing a decrease in retinal cells proliferation.	Tetradecanoylphorbol Acetate	73-76	protein kinase C, gamma	Rattus norvegicus	81-84
1426027-3	1992	Both TPA- and staurosporine-caused ODC inductions were markedly suppressed in the PKC-down-regulated cells.	Tetradecanoylphorbol Acetate	5-8	ornithine decarboxylase, structural 1	Mus musculus	35-38
18056199-5	2007	RESULTS: We show that the combination of TRAIL with low-dose TPA has no effect on nonmalignant prostate epithelial cells; however, TPA up-regulates most AP-1 proteins and AP-1 activity, reduces c-FLIP(L), and potentiates TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	131-134	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	171-175
1405765-4	1992	Two antibodies, MEP21 and MEP26, reacted with proteins of 150 and 47-60 kDa, respectively, which are expressed on the surface of E26 progenitor cells but whose expression is extinguished following TPA-induced differentiation.	Tetradecanoylphorbol Acetate	197-200	podocalyxin like	Gallus gallus	16-21
18056199-8	2007	In vivo xenograft experiments suggest that TPA elevates the expression of c-Fos and reduces c-FLIP(L).	Tetradecanoylphorbol Acetate	43-46	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-79
19360311-9	2009	The first group characterized by low basal MMP-9 secretion fell into three different categories of susceptibility to PMA induction of MMP-9 expression: resistant, moderately susceptible and highly susceptible.	Tetradecanoylphorbol Acetate	117-120	matrix metallopeptidase 9	Homo sapiens	134-139
19360311-10	2009	High basal MMP-9 levels responsive to PMA induction characterized the second group.	Tetradecanoylphorbol Acetate	38-41	matrix metallopeptidase 9	Homo sapiens	11-16
19912882-7	1992	Incubation of neuroblastoma cells with the active phorbol ester, phorbol 12-myristate 13-acetate (PMA), increased expression of CAT from pTH(-245/+2 1)CAT over 6-fold and was accompanied by induction of c-fos and c-jun mRNAs and proteins.	Tetradecanoylphorbol Acetate	65-96	parathyroid hormone	Bos taurus	137-140
19379553-4	2009	Meanwhile, PCR, cloning and direct DNA sequencing were used to identify mutations in the 5" regulatory region of bcl-6 in K562 cells before and after induction with TPA.	Tetradecanoylphorbol Acetate	165-168	BCL6 transcription repressor	Homo sapiens	113-118
17982670-2	2007	In this study, the expression of B7-DC, -H1, -H2, and -H3 in response to TPA was markedly induced in K562 cells.	Tetradecanoylphorbol Acetate	73-76	programmed cell death 1 ligand 2	Homo sapiens	33-38
17982670-4	2007	Pre-treatments with protein kinase C (PKC) inhibitors significantly inhibited TPA-induced expression of B7-DC, -H1, -H2, and -H3 mRNA as well as TPA-induced phosphorylation of ERK, p38 MAPK, JNK, and PI-3K.	Tetradecanoylphorbol Acetate	78-81	programmed cell death 1 ligand 2	Homo sapiens	104-128
17982670-5	2007	TPA-induced expression of B7-DC, -H1, -H2, and -H3 mRNA was abrogated by pre-treatments with inhibitors of ERK and p38 MAPK.	Tetradecanoylphorbol Acetate	0-3	programmed cell death 1 ligand 2	Homo sapiens	26-50
19912882-7	1992	Incubation of neuroblastoma cells with the active phorbol ester, phorbol 12-myristate 13-acetate (PMA), increased expression of CAT from pTH(-245/+2 1)CAT over 6-fold and was accompanied by induction of c-fos and c-jun mRNAs and proteins.	Tetradecanoylphorbol Acetate	65-96	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	203-208
19912882-7	1992	Incubation of neuroblastoma cells with the active phorbol ester, phorbol 12-myristate 13-acetate (PMA), increased expression of CAT from pTH(-245/+2 1)CAT over 6-fold and was accompanied by induction of c-fos and c-jun mRNAs and proteins.	Tetradecanoylphorbol Acetate	65-96	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	213-218
17277233-4	2007	We found that EP2 knockout mice had reduced cyclooxygenase-2 (COX-2) expression after 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment compared with wild-type (WT) mice.	Tetradecanoylphorbol Acetate	86-122	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	14-17
17277233-4	2007	We found that EP2 knockout mice had reduced cyclooxygenase-2 (COX-2) expression after 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment compared with wild-type (WT) mice.	Tetradecanoylphorbol Acetate	124-127	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	14-17
17277233-5	2007	Further, primary keratinocytes from EP2 transgenic mice had increased COX-2 expression after either TPA or PGE2 treatment and COX-2 expression was blocked by 10 microM SQ 22,536, an adenylate cyclase inhibitor.	Tetradecanoylphorbol Acetate	100-103	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	36-39
19250646-0	2009	Involvement of PKC alpha in PMA-induced facilitation of exocytosis and vesicle fusion in PC12 cells.	Tetradecanoylphorbol Acetate	28-31	protein kinase C, alpha	Rattus norvegicus	15-24
19250646-4	2009	Amperometric measurements based on carbon fiber microelectrodes demonstrated that PKC alpha has a key role in the PMA-mediated facilitation of exocytosis and vesicle fusion in neuroendocrine PC12 cells.	Tetradecanoylphorbol Acetate	114-117	protein kinase C, alpha	Rattus norvegicus	82-91
19912882-7	1992	Incubation of neuroblastoma cells with the active phorbol ester, phorbol 12-myristate 13-acetate (PMA), increased expression of CAT from pTH(-245/+2 1)CAT over 6-fold and was accompanied by induction of c-fos and c-jun mRNAs and proteins.	Tetradecanoylphorbol Acetate	98-101	parathyroid hormone	Bos taurus	137-140
19912882-7	1992	Incubation of neuroblastoma cells with the active phorbol ester, phorbol 12-myristate 13-acetate (PMA), increased expression of CAT from pTH(-245/+2 1)CAT over 6-fold and was accompanied by induction of c-fos and c-jun mRNAs and proteins.	Tetradecanoylphorbol Acetate	98-101	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	203-208
19912882-7	1992	Incubation of neuroblastoma cells with the active phorbol ester, phorbol 12-myristate 13-acetate (PMA), increased expression of CAT from pTH(-245/+2 1)CAT over 6-fold and was accompanied by induction of c-fos and c-jun mRNAs and proteins.	Tetradecanoylphorbol Acetate	98-101	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	213-218
19179613-5	2009	These lal(-/-) T cells lost the ability to respond to T cell receptor stimulation, including reduced expression of cell surface receptor CD69, abolishment of T cell proliferation, and decreased expression of T lymphokines after stimulation by either anti-CD3 plus anti-CD28 or phorbol-12-myristate-13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	277-308	lysosomal acid lipase A	Mus musculus	6-9
17277233-6	2007	EP2 knockout mice had significantly decreased, whereas EP2 transgenic mice had significantly increased PGE2 production in response to a single treatment of TPA.	Tetradecanoylphorbol Acetate	156-159	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	55-58
1527003-4	1992	Densitometric analysis of autoradiograms revealed that phorbol myristate acetate caused a 3.78 +/- 0.97-fold increase in MARCKS phosphorylation over control.	Tetradecanoylphorbol Acetate	55-80	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	121-127
17786281-3	2007	These effects were blocked by a tyrosine kinase inhibitor (PP2) or Src small interfering RNA (siRNA), indicating that Src was involved in the PMA-induced activation of Cas/Crk/Rac1 signaling pathway.	Tetradecanoylphorbol Acetate	142-145	Rac family small GTPase 1	Homo sapiens	176-180
17786281-10	2007	We propose that PMA-induced migration was dependent on activation of PKC/Src/Cas/Crk/Rac1 signaling pathway via modulating cytoskeletal reorganization during glioblastoma cell migration.	Tetradecanoylphorbol Acetate	16-19	Rac family small GTPase 1	Homo sapiens	85-89
17804722-5	2007	When cells were stimulated with tumor promoters, such as epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylation of RSK was increased within 5 min.	Tetradecanoylphorbol Acetate	90-126	ribosomal protein S6 kinase polypeptide 1	Mus musculus	153-156
18710402-3	2009	CD4(+) T cells were activated with phorbol 12-myristate 13-acetate (PMA) and different concentrations of a Ca(2+) ionophore, Ionomycin (I), or a sarcoplasmic Ca(2+) ATPase inhibitor, Thapsigargin (TG).	Tetradecanoylphorbol Acetate	35-66	CD4 antigen	Mus musculus	0-3
18710402-3	2009	CD4(+) T cells were activated with phorbol 12-myristate 13-acetate (PMA) and different concentrations of a Ca(2+) ionophore, Ionomycin (I), or a sarcoplasmic Ca(2+) ATPase inhibitor, Thapsigargin (TG).	Tetradecanoylphorbol Acetate	68-71	CD4 antigen	Mus musculus	0-3
1325212-7	1992	We demonstrated that EBV-positive cell lines derived from patients with American Burkitt"s lymphoma, and especially those from patients with AIDS, constitutively express large quantities of hIL-10 by Northern blot analysis and ELISA (range, 3,101 to 25,915 pg/mL), and that both teleocidin and PMA induce hIL-10 in these cell lines.	Tetradecanoylphorbol Acetate	294-297	interleukin 10	Homo sapiens	190-196
19124542-6	2009	In contrast, the phorbol ester PMA (phorbol-12-myristate-13-acetate, a pharmacological mimic of the downstream mediator diacylglycerol in alpha-adrenergic signalling), caused continuous PKD-dependent HDAC5-GFP nuclear efflux and maintained PKD1-mPlum redistribution.	Tetradecanoylphorbol Acetate	36-67	protein kinase D1	Mus musculus	186-189
19124542-7	2009	In the absence of expressed HDAC, PMA increased histone H3 acetylation and increased MEF2 reporter activity in a PKD-dependent manner, consistent with PKD phosphorylation of endogenous HDAC(s) and reduced nuclear HDAC activity due to HDAC nuclear efflux.	Tetradecanoylphorbol Acetate	34-37	protein kinase D1	Mus musculus	113-116
19124542-7	2009	In the absence of expressed HDAC, PMA increased histone H3 acetylation and increased MEF2 reporter activity in a PKD-dependent manner, consistent with PKD phosphorylation of endogenous HDAC(s) and reduced nuclear HDAC activity due to HDAC nuclear efflux.	Tetradecanoylphorbol Acetate	34-37	protein kinase D1	Mus musculus	151-154
17630204-4	2007	Isoeugenol inhibited phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io)-induced IL-2 mRNA expression and protein secretion in B6C3F1 mouse splenocytes, and in EL4.IL-2 mouse T-cells, as determined by real-time RT-PCR and ELISA, respectively.	Tetradecanoylphorbol Acetate	21-52	epilepsy 4	Mus musculus	166-169
17630204-4	2007	Isoeugenol inhibited phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io)-induced IL-2 mRNA expression and protein secretion in B6C3F1 mouse splenocytes, and in EL4.IL-2 mouse T-cells, as determined by real-time RT-PCR and ELISA, respectively.	Tetradecanoylphorbol Acetate	54-57	epilepsy 4	Mus musculus	166-169
1508194-9	1992	Autophosphorylation of immunoprecipitated nPKC theta was observed; it was enhanced by phosphatidylserine and 12-O-tetradecanoylphorbol-13-acetate but attenuated by the addition of Ca2+.	Tetradecanoylphorbol Acetate	109-145	protein kinase C, theta	Mus musculus	42-52
17671741-6	2007	GF109203X, an inhibitor of the classic and the novel protein kinase C isoenzymes, and Go6976, the selective inhibitor of the classical cPKC isoenzymes were able to abolish the effect of PMA or/and Ca-ionophore on the calcineurin activity with concomitant reversal of the hyperphosphorylation of Cabin 1.	Tetradecanoylphorbol Acetate	186-189	calcineurin binding protein 1	Homo sapiens	295-302
19258426-5	2009	Pretreatment with NSC 676914 is here shown to repress 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IkappaB-alpha phosphorylation and translocation of p65/50 to the nucleus but not the processing of p52 from p100, suggesting the inhibition of NF-kappaB regulator IKKbeta rather than IKKalpha.	Tetradecanoylphorbol Acetate	54-90	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	288-296
19258426-5	2009	Pretreatment with NSC 676914 is here shown to repress 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced IkappaB-alpha phosphorylation and translocation of p65/50 to the nucleus but not the processing of p52 from p100, suggesting the inhibition of NF-kappaB regulator IKKbeta rather than IKKalpha.	Tetradecanoylphorbol Acetate	92-95	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	288-296
17619933-2	2007	We describe a case of a 77-year-old patient with a presumed ischemic cerebral infarct, in whom planned treatment with tissue plasminogen activator therapy (TPA) was withheld because of partial spontaneous improvement in his condition.	Tetradecanoylphorbol Acetate	156-159	chromosome 20 open reading frame 181	Homo sapiens	118-146
19208844-4	2009	The promoter assay showed that MMP-9 promoter activity was suppressed by RECK and that RECK-mediated suppression of MMP-9 promoter activity requires 12-O-tetradecanoylphorbol-13-acetate-responsive element (TRE) and kappaB sites.	Tetradecanoylphorbol Acetate	149-185	matrix metallopeptidase 9	Homo sapiens	31-36
19208844-4	2009	The promoter assay showed that MMP-9 promoter activity was suppressed by RECK and that RECK-mediated suppression of MMP-9 promoter activity requires 12-O-tetradecanoylphorbol-13-acetate-responsive element (TRE) and kappaB sites.	Tetradecanoylphorbol Acetate	149-185	matrix metallopeptidase 9	Homo sapiens	116-121
1324189-2	1992	Pretreatment of astrocytes with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), attenuated CNP-induced cGMP responses in a dose-dependent manner, with a half-maximal inhibitory concentration of 6 nM, whereas the inactive phorbol ester analog, 4 alpha-phorbol 12,13-didecanoate, was without effect.	Tetradecanoylphorbol Acetate	32-63	natriuretic peptide type C	Mus musculus	122-125
19015273-3	2009	In this study, we show that activated PKCdelta (wild-type PKCdelta stimulated by phorbol 12-myristate 13-acetate or constitutively active PKCdelta) decreased Gli-luciferase reporter activity in NIH/3T3 cells, as well as the endogenous hedgehog-responsive gene PTCH1.	Tetradecanoylphorbol Acetate	81-112	protein kinase C, delta	Mus musculus	38-46
19015273-3	2009	In this study, we show that activated PKCdelta (wild-type PKCdelta stimulated by phorbol 12-myristate 13-acetate or constitutively active PKCdelta) decreased Gli-luciferase reporter activity in NIH/3T3 cells, as well as the endogenous hedgehog-responsive gene PTCH1.	Tetradecanoylphorbol Acetate	81-112	protein kinase C, delta	Mus musculus	58-66
19015273-3	2009	In this study, we show that activated PKCdelta (wild-type PKCdelta stimulated by phorbol 12-myristate 13-acetate or constitutively active PKCdelta) decreased Gli-luciferase reporter activity in NIH/3T3 cells, as well as the endogenous hedgehog-responsive gene PTCH1.	Tetradecanoylphorbol Acetate	81-112	protein kinase C, delta	Mus musculus	58-66
19015273-3	2009	In this study, we show that activated PKCdelta (wild-type PKCdelta stimulated by phorbol 12-myristate 13-acetate or constitutively active PKCdelta) decreased Gli-luciferase reporter activity in NIH/3T3 cells, as well as the endogenous hedgehog-responsive gene PTCH1.	Tetradecanoylphorbol Acetate	81-112	GLI family zinc finger 1	Homo sapiens	158-161
19029298-8	2009	Collectively, these results implicate PKD1-Ser744 phosphorylation in the phorbol 12-myristate 13-acetate-dependent mechanism that increases PKD1 activity toward physiologically relevant substrates.	Tetradecanoylphorbol Acetate	73-104	protein kinase D1	Homo sapiens	38-42
19029298-8	2009	Collectively, these results implicate PKD1-Ser744 phosphorylation in the phorbol 12-myristate 13-acetate-dependent mechanism that increases PKD1 activity toward physiologically relevant substrates.	Tetradecanoylphorbol Acetate	73-104	protein kinase D1	Homo sapiens	140-144
17569658-5	2007	In contrast, we show that PKCdelta-Thr(505) phosphorylation dynamically increases in cardiomyocytes treated with phorbol 12-myristate 13-acetate or the alpha(1)-adrenergic receptor agonist norepinephrine via a mechanism that requires novel PKC isoform activity and not phosphoinositide-dependent kinase-1.	Tetradecanoylphorbol Acetate	113-144	protein kinase C, delta	Mus musculus	26-34
17569658-5	2007	In contrast, we show that PKCdelta-Thr(505) phosphorylation dynamically increases in cardiomyocytes treated with phorbol 12-myristate 13-acetate or the alpha(1)-adrenergic receptor agonist norepinephrine via a mechanism that requires novel PKC isoform activity and not phosphoinositide-dependent kinase-1.	Tetradecanoylphorbol Acetate	113-144	protein kinase C, delta	Mus musculus	26-29
1324189-2	1992	Pretreatment of astrocytes with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), attenuated CNP-induced cGMP responses in a dose-dependent manner, with a half-maximal inhibitory concentration of 6 nM, whereas the inactive phorbol ester analog, 4 alpha-phorbol 12,13-didecanoate, was without effect.	Tetradecanoylphorbol Acetate	65-68	natriuretic peptide type C	Mus musculus	122-125
1324189-3	1992	In the presence of staurosporine, a PKC inhibitor, the inhibitory effect of PMA on CNP-stimulated cGMP production was reversed.	Tetradecanoylphorbol Acetate	76-79	natriuretic peptide type C	Mus musculus	83-86
17507007-4	2007	FPP-3 also suppressed TPA-induced increases in MMP-9 protein and mRNA levels, but did not alter TIMP-1 level.	Tetradecanoylphorbol Acetate	22-25	matrix metallopeptidase 9	Homo sapiens	47-52
1323347-2	1992	In endothelial cells, the stimulation of tPA production by phorbol 12-myristate 13-acetate (PMA) was potentiated 1.9-fold by 10 mumol/L t-RA, or 1.8 times the additive effect.	Tetradecanoylphorbol Acetate	59-90	chromosome 20 open reading frame 181	Homo sapiens	41-44
19331173-10	2009	Resveratrol reduced the PMA-induced ICAM-1 expression in HT1080 cells as determined by RT-PCR, flow cytometry and ELISA.	Tetradecanoylphorbol Acetate	24-27	intercellular adhesion molecule 1	Homo sapiens	36-42
1323347-2	1992	In endothelial cells, the stimulation of tPA production by phorbol 12-myristate 13-acetate (PMA) was potentiated 1.9-fold by 10 mumol/L t-RA, or 1.8 times the additive effect.	Tetradecanoylphorbol Acetate	92-95	chromosome 20 open reading frame 181	Homo sapiens	41-44
18992303-6	2009	Moreover, ICER II mRNA expression was transiently induced by stimulation with PMA and ionomycin in normal glucose cultures; however, with high glucose, the induction disappeared.	Tetradecanoylphorbol Acetate	78-81	cAMP responsive element modulator	Homo sapiens	10-14
17908428-4	2007	The percentages of cell differentiation in JWA containing vectors transfected cells treated with TPA were significantly higher those of MCF-7-N1 cells (vector only control).	Tetradecanoylphorbol Acetate	97-100	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	43-46
17908428-6	2007	CONCLUSION: JWA transfection enhanced MCF-7 cell differentiation induced by TPA significantly, and PKC sites mutation in JWA coding region has no obviously effect on TPA-induced MCF-7 cell differentiation.	Tetradecanoylphorbol Acetate	76-79	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	12-15
1323347-4	1992	Higher concentrations of t-RA (400 nmol/L) depressed tPA secretion by itself and also suppressed PMA-induced tPA production by 50%.	Tetradecanoylphorbol Acetate	97-100	chromosome 20 open reading frame 181	Homo sapiens	109-112
1323347-8	1992	Nor did 10 nmol/L PMA and 40 nmol/L t-RA together affect cAMP levels, suggesting that t-RA-mediated potentiation of PMA-induced tPA production occurred via a mechanism that was independent of cAMP levels.	Tetradecanoylphorbol Acetate	116-119	chromosome 20 open reading frame 181	Homo sapiens	128-131
1639133-4	1992	However, the three microtubule-disrupting agents--colchicine, nocodazole, and tubulazole--depressed the stimulation of tPA secretion by phorbol myristate acetate (PMA) by 50- to 65%.	Tetradecanoylphorbol Acetate	136-161	chromosome 20 open reading frame 181	Homo sapiens	119-122
17234720-0	2007	Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B.	Tetradecanoylphorbol Acetate	23-59	ornithine decarboxylase, structural 1	Mus musculus	157-180
17234720-5	2007	To further elucidate the molecular mechanisms underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling molecules controlling these proteins were explored in mouse skin.	Tetradecanoylphorbol Acetate	126-129	ornithine decarboxylase, structural 1	Mus musculus	152-175
17234720-5	2007	To further elucidate the molecular mechanisms underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling molecules controlling these proteins were explored in mouse skin.	Tetradecanoylphorbol Acetate	126-129	ornithine decarboxylase, structural 1	Mus musculus	177-180
17234720-7	2007	When mouse skin was treated after TPA-induced production of papillomas, xanthorrhizol remarkably suppressed the expression of ODC, iNOS and COX-2 and inhibited the activation of NF-kappaB.	Tetradecanoylphorbol Acetate	34-37	ornithine decarboxylase, structural 1	Mus musculus	126-129
19229172-2	2008	In order to label IL-17-secreting cells, a single cell suspension of mouse splenocytes is prepared and stimulated at 37 degrees C with PMA/ionomycin to induce cytokine secretion.	Tetradecanoylphorbol Acetate	135-138	interleukin 17A	Mus musculus	18-23
18975922-0	2008	Phorbol-12-myristate 13-acetate acting through protein kinase Cepsilon induces translocator protein (18-kDa) TSPO gene expression.	Tetradecanoylphorbol Acetate	0-31	transcription elongation factor B (SIII), polypeptide 2 (elongin B),-like	Mus musculus	101-107
18820286-3	2008	We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin.	Tetradecanoylphorbol Acetate	71-107	ornithine decarboxylase, structural 1	Mus musculus	209-232
18820286-3	2008	We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin.	Tetradecanoylphorbol Acetate	71-107	ornithine decarboxylase, structural 1	Mus musculus	234-237
18820286-3	2008	We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin.	Tetradecanoylphorbol Acetate	109-112	ornithine decarboxylase, structural 1	Mus musculus	209-232
18820286-3	2008	We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin.	Tetradecanoylphorbol Acetate	109-112	ornithine decarboxylase, structural 1	Mus musculus	234-237
1639133-4	1992	However, the three microtubule-disrupting agents--colchicine, nocodazole, and tubulazole--depressed the stimulation of tPA secretion by phorbol myristate acetate (PMA) by 50- to 65%.	Tetradecanoylphorbol Acetate	163-166	chromosome 20 open reading frame 181	Homo sapiens	119-122
1639858-2	1992	Using the phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate (TPA) and calcium, two agents known to induce keratinocyte differentiation in vitro, we examined the expression of the genes encoding c-fos, c-myc, and c-jun; involucrin, a protein precursor of the keratinocyte cornified envelope; and L-7, a ribosomal protein.	Tetradecanoylphorbol Acetate	24-61	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	196-201
18684713-6	2008	Glutamate transport assay revealed that increasing the expression of Arl6ip1 in C6BU-1 cells markedly enhanced Na+-dependent EAAC1-mediated glutamate transport activity in the presence of 100 nm phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	195-226	solute carrier family 1 member 1	Rattus norvegicus	125-130
17612968-11	2007	PKC-gamma could be further activated by 400 nM phorbol-12-myristate-13-acetate (PMA), but the PKC-gamma protein levels remained constant.	Tetradecanoylphorbol Acetate	47-78	protein kinase C, gamma	Rattus norvegicus	0-9
17612968-11	2007	PKC-gamma could be further activated by 400 nM phorbol-12-myristate-13-acetate (PMA), but the PKC-gamma protein levels remained constant.	Tetradecanoylphorbol Acetate	80-83	protein kinase C, gamma	Rattus norvegicus	0-9
1639858-2	1992	Using the phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate (TPA) and calcium, two agents known to induce keratinocyte differentiation in vitro, we examined the expression of the genes encoding c-fos, c-myc, and c-jun; involucrin, a protein precursor of the keratinocyte cornified envelope; and L-7, a ribosomal protein.	Tetradecanoylphorbol Acetate	63-66	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	196-201
17114644-0	2007	Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms.	Tetradecanoylphorbol Acetate	24-27	matrix metallopeptidase 9	Homo sapiens	37-63
17114644-2	2007	Here, we found that an antitumor antibiotic, ascofuranone, inhibits invasion and MMP-9 induction induced by phorbol myristate acetate (PMA) in human cell lines.	Tetradecanoylphorbol Acetate	108-133	matrix metallopeptidase 9	Homo sapiens	81-86
18553255-4	2008	WNT-4 mRNA expression was clearly upregulated by ACTH and 8-bromo-cAMP (8-BrcAMP) in primary cultures of normal adult adrenocortical cells, but downregulated by 8-BrcAMP and 12- O-tetradecanoylphorbol-13-acetate (TPA) in human NCI-H295R adrenocortical carcinoma cells.	Tetradecanoylphorbol Acetate	174-211	Wnt family member 4	Homo sapiens	0-5
1641975-5	1992	UV-crosslinking analysis of NF-kappa B-specific proteins induced in TPA-treated cells showed the presence of 45 and 55 kDa NF-kappa B-binding protein in TPA-induced HNHIVdt4 cells while, in HNHIV alpha 1 cells, we detected only 55-, 110-, and 200-kDa proteins, but no 45-kDa protein.	Tetradecanoylphorbol Acetate	68-71	programmed cell death 11	Homo sapiens	123-149
18553255-4	2008	WNT-4 mRNA expression was clearly upregulated by ACTH and 8-bromo-cAMP (8-BrcAMP) in primary cultures of normal adult adrenocortical cells, but downregulated by 8-BrcAMP and 12- O-tetradecanoylphorbol-13-acetate (TPA) in human NCI-H295R adrenocortical carcinoma cells.	Tetradecanoylphorbol Acetate	213-216	Wnt family member 4	Homo sapiens	0-5
18619673-6	2008	In contrast, PMA treatment (but not forskolin) resulted in a 2-fold increase in production of galanin and somatostatin, and a 3-fold increase in NPY production.	Tetradecanoylphorbol Acetate	13-16	somatostatin	Homo sapiens	106-118
17114644-2	2007	Here, we found that an antitumor antibiotic, ascofuranone, inhibits invasion and MMP-9 induction induced by phorbol myristate acetate (PMA) in human cell lines.	Tetradecanoylphorbol Acetate	135-138	matrix metallopeptidase 9	Homo sapiens	81-86
1641975-5	1992	UV-crosslinking analysis of NF-kappa B-specific proteins induced in TPA-treated cells showed the presence of 45 and 55 kDa NF-kappa B-binding protein in TPA-induced HNHIVdt4 cells while, in HNHIV alpha 1 cells, we detected only 55-, 110-, and 200-kDa proteins, but no 45-kDa protein.	Tetradecanoylphorbol Acetate	153-156	programmed cell death 11	Homo sapiens	123-149
1634545-0	1992	Interaction of AP-1-, AP-2-, and Sp1-like proteins with two distinct sites in the upstream regulatory region of the plasminogen activator inhibitor-1 gene mediates the phorbol 12-myristate 13-acetate response.	Tetradecanoylphorbol Acetate	168-199	transcription factor AP-2 alpha	Homo sapiens	22-26
17551222-5	2007	In adhesion studies, CoMS weakly but spontaneously adhered to fibronectin (FN), which was enhanced by phorbol ester (TPA), while CM-MC and VI-MC required cell activation by TPA to adhere to FN.	Tetradecanoylphorbol Acetate	117-120	fibronectin 1	Canis lupus familiaris	62-73
1352969-4	1992	However, differentiation of these cells, as promoted by 12-O-tetradecanoylphorbol-13-acetate actually resulted in decreased levels of hsp60 mRNA expression as well as mitochondrial RNA expression, suggesting significant differences in involvement of mitochondria in the differentiation of these cell lineages.	Tetradecanoylphorbol Acetate	56-92	heat shock protein family D (Hsp60) member 1	Homo sapiens	134-139
17207890-5	2007	TNF-alpha stimulated expression of both chemokines, while the PKCalpha/beta activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced only expression of IL-8 and inhibited TNF-alpha-induced RANTES expression.	Tetradecanoylphorbol Acetate	86-123	C-C motif chemokine ligand 5	Homo sapiens	194-200
17207890-5	2007	TNF-alpha stimulated expression of both chemokines, while the PKCalpha/beta activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced only expression of IL-8 and inhibited TNF-alpha-induced RANTES expression.	Tetradecanoylphorbol Acetate	125-128	C-C motif chemokine ligand 5	Homo sapiens	194-200
17350626-8	2007	The phosphorylation of MEK1/2 and Raf-1 induced by ET-1 or TPA were also inhibited by EGCG.	Tetradecanoylphorbol Acetate	59-62	v-raf-leukemia viral oncogene 1	Mus musculus	34-39
18813807-0	2008	Rac1 mediates phorbol 12-myristate 13-acetate-induced migration of glioblastoma cells via paxillin.	Tetradecanoylphorbol Acetate	14-45	Rac family small GTPase 1	Homo sapiens	0-4
18813807-1	2008	Previously, we reported that phorbol 12-myristate 13-acetate (PMA)-activated protein kinase C (PKC) induced Rac1 activation in A172 glioblastoma cells.	Tetradecanoylphorbol Acetate	29-60	Rac family small GTPase 1	Homo sapiens	108-112
18813807-1	2008	Previously, we reported that phorbol 12-myristate 13-acetate (PMA)-activated protein kinase C (PKC) induced Rac1 activation in A172 glioblastoma cells.	Tetradecanoylphorbol Acetate	62-65	Rac family small GTPase 1	Homo sapiens	108-112
18628248-4	2008	Application of QUE significantly suppressed TPA-induced activation of the PKCdelta/ERK/AP-1-signaling cascade.	Tetradecanoylphorbol Acetate	44-47	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	87-91
18628248-6	2008	Results suggested that OH groups at both C3" and C4" play central roles in QUE"s inhibition of TPA-induced MMP-9 activation and migration, and an additional OH at C3, C5 or C7 may increase the inhibitory potency of the 3",4"-diOH flavone against TPA-induced MMP-9 activity and migration.	Tetradecanoylphorbol Acetate	95-98	matrix metallopeptidase 9	Homo sapiens	107-112
18628248-6	2008	Results suggested that OH groups at both C3" and C4" play central roles in QUE"s inhibition of TPA-induced MMP-9 activation and migration, and an additional OH at C3, C5 or C7 may increase the inhibitory potency of the 3",4"-diOH flavone against TPA-induced MMP-9 activity and migration.	Tetradecanoylphorbol Acetate	95-98	matrix metallopeptidase 9	Homo sapiens	258-263
1358239-0	1992	Micromanipulation of adhesion of phorbol 12-myristate-13-acetate-stimulated T lymphocytes to planar membranes containing intercellular adhesion molecule-1.	Tetradecanoylphorbol Acetate	33-64	intercellular adhesion molecule 1	Homo sapiens	121-154
18487372-6	2008	HCECs were incubated with and without activators (IgE-activated mast cell supernates, phorbol myristate acetate [PMA; to activate TACE], TNFalpha, and IFNgamma [to upregulate TNFR1]) for 24 hours.	Tetradecanoylphorbol Acetate	86-111	ADAM metallopeptidase domain 17	Homo sapiens	130-134
1358239-4	1992	T lymphocytes stimulated with phorbol 12-myristate-13-acetate (PMA) conjugated strongly with the planar membrane containing purified ICAM-1.	Tetradecanoylphorbol Acetate	30-61	intercellular adhesion molecule 1	Homo sapiens	133-139
17397398-6	2007	Monitoring individual tPA-CFP release events revealed that "full release" events are increased in Syt VII-GFP-expressing cells, but not in Syt VII-DN-GFP-expressing or Syt VII-silenced cells.	Tetradecanoylphorbol Acetate	22-25	synaptotagmin 7	Rattus norvegicus	98-105
1358239-4	1992	T lymphocytes stimulated with phorbol 12-myristate-13-acetate (PMA) conjugated strongly with the planar membrane containing purified ICAM-1.	Tetradecanoylphorbol Acetate	63-66	intercellular adhesion molecule 1	Homo sapiens	133-139
1358239-8	1992	The physical strength of adhesion between a PMA-stimulated T lymphocyte and a planar membrane containing 1,000 ICAM-1 molecules/micron 2 was comparable to the strength of adhesion between a cytotoxic T cell and its target cell.	Tetradecanoylphorbol Acetate	44-47	intercellular adhesion molecule 1	Homo sapiens	111-117
21479483-12	2008	Although phorbol 12-myristate 13-acetate treatment induced MMP-9 activity in E-type cells, it had no effect on R-type cells.	Tetradecanoylphorbol Acetate	9-40	matrix metallopeptidase 9	Homo sapiens	59-64
1612026-7	1992	The protein kinase-C (PKC) activator phorbol 12-myristate 13-acetate increased [3H]thymidine incorporation, and TGF beta inhibited this action of phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	37-68	protein kinase C, gamma	Rattus norvegicus	4-20
18690222-5	2008	Mice doubly deficient in MSK1 and MSK2 were hypersensitive to lipopolysaccharide-induced endotoxic shock and showed prolonged inflammation in a model of toxic contact eczema induced by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	185-216	ribosomal protein S6 kinase, polypeptide 4	Mus musculus	34-38
18477669-4	2008	Treatment with TPA increased transepithelial electrical resistance, with tight junction barrier function more than 4-fold that of the control, together with up-regulation of tight junction proteins, occludin, zona occludens (ZO)-1, ZO-2 and claudin-1 at the transcriptional level.	Tetradecanoylphorbol Acetate	15-18	claudin 1	Homo sapiens	241-250
18477669-8	2008	The knockdown of GATA-3 using RNA interference resulted in inhibition of up-regulation of ZO-1 and ZO-2 by treatment with TPA.	Tetradecanoylphorbol Acetate	122-125	GATA binding protein 3	Homo sapiens	17-23
17214970-0	2007	Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	21-24	matrix metallopeptidase 9	Homo sapiens	33-38
17214970-2	2007	In this study, we examined the inhibitory effect of silibinin, a flavonoid antioxidant from milk thistle (Silybum marianum L.) on PMA-induced MMP-9 expression in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	130-133	matrix metallopeptidase 9	Homo sapiens	142-147
17214970-3	2007	Silibinin significantly and selectively suppressed PMA-induced MMP-9 expression in MCF-7.	Tetradecanoylphorbol Acetate	51-54	matrix metallopeptidase 9	Homo sapiens	63-68
18534633-9	2008	Taken together, hemin inhibited TPA-induced COX-2 expression by altering NF-kappaB signaling pathway via ERK and p38 MAPK, as well as TPA-induced ODC expression in mouse skin.	Tetradecanoylphorbol Acetate	134-137	ornithine decarboxylase, structural 1	Mus musculus	146-149
1612026-7	1992	The protein kinase-C (PKC) activator phorbol 12-myristate 13-acetate increased [3H]thymidine incorporation, and TGF beta inhibited this action of phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	37-68	protein kinase C, gamma	Rattus norvegicus	22-25
1612026-7	1992	The protein kinase-C (PKC) activator phorbol 12-myristate 13-acetate increased [3H]thymidine incorporation, and TGF beta inhibited this action of phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	146-177	protein kinase C, gamma	Rattus norvegicus	4-20
17149700-8	2007	Notably, 12-O-tetradecanoyl-13-phorbol acetate (TPA) mediated intracellular translocation of RACK1-interacting PKC alpha and delta was abrogated in RACK1DeltaWD1-expressing cells.	Tetradecanoylphorbol Acetate	48-51	receptor for activated C kinase 1	Mus musculus	93-98
1612026-7	1992	The protein kinase-C (PKC) activator phorbol 12-myristate 13-acetate increased [3H]thymidine incorporation, and TGF beta inhibited this action of phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	146-177	protein kinase C, gamma	Rattus norvegicus	22-25
17149700-8	2007	Notably, 12-O-tetradecanoyl-13-phorbol acetate (TPA) mediated intracellular translocation of RACK1-interacting PKC alpha and delta was abrogated in RACK1DeltaWD1-expressing cells.	Tetradecanoylphorbol Acetate	48-51	receptor for activated C kinase 1	Mus musculus	148-153
1618916-6	1992	Activation of the NADPH oxidase by phorbol myristate acetate, F-, N-formyl-methionyl-leucyl-phenylalanine (FMLP), or tumor necrosis factor (TNF) dramatically reduced autofluorescence levels.	Tetradecanoylphorbol Acetate	35-60	2,4-dienoyl-CoA reductase 1	Homo sapiens	18-23
17131377-0	2007	Role of ROS and MAPK in TPA-induced ICAM-1 expression in the myeloid ML-1 cell line.	Tetradecanoylphorbol Acetate	24-27	intercellular adhesion molecule 1	Homo sapiens	36-42
1416026-5	1992	Studies on the protooncogene-encoded transcription factor c-Jun employing this assay revealed a TPA-inducible protein dephosphorylation event that strongly increases the DNA-binding potential of the protein.	Tetradecanoylphorbol Acetate	96-99	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-63
17131377-2	2007	Though induction of ICAM-1 by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in myeloid cells has been reported, the molecular mechanism by which TPA upregulates ICAM-1 expression remains unclear.	Tetradecanoylphorbol Acetate	30-67	intercellular adhesion molecule 1	Homo sapiens	20-26
17131377-2	2007	Though induction of ICAM-1 by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in myeloid cells has been reported, the molecular mechanism by which TPA upregulates ICAM-1 expression remains unclear.	Tetradecanoylphorbol Acetate	69-72	intercellular adhesion molecule 1	Homo sapiens	20-26
17131377-2	2007	Though induction of ICAM-1 by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in myeloid cells has been reported, the molecular mechanism by which TPA upregulates ICAM-1 expression remains unclear.	Tetradecanoylphorbol Acetate	143-146	intercellular adhesion molecule 1	Homo sapiens	20-26
17131377-2	2007	Though induction of ICAM-1 by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in myeloid cells has been reported, the molecular mechanism by which TPA upregulates ICAM-1 expression remains unclear.	Tetradecanoylphorbol Acetate	143-146	intercellular adhesion molecule 1	Homo sapiens	159-165
17131377-3	2007	In the present study, we investigated the signaling mechanism associated with TPA-induced ICAM-1 expression in ML-1 cells.	Tetradecanoylphorbol Acetate	78-81	intercellular adhesion molecule 1	Homo sapiens	90-96
1572414-1	1992	Insulin and the phorbol ester, phorbol 12-myristate 13-acetate, induce beta-actin gene transcription in H4 cells.	Tetradecanoylphorbol Acetate	31-62	POTE ankyrin domain family member F	Homo sapiens	71-81
17131377-4	2007	Herein, our microarray, flow cytometry, and Western blot analysis indicated that ICAM-1 was constitutively expressed at a low level in ML-1 cells, but its expression was further upregulated at both the mRNA and protein levels in response to TPA.	Tetradecanoylphorbol Acetate	241-244	intercellular adhesion molecule 1	Homo sapiens	81-87
17131377-5	2007	ICAM-1 expression in response to TPA was inhibited by pretreatment with GF109203X [a specific inhibitor of protein kinase C (PKC)], or with PD98059 and U0126 (specific inhibitors of MEK), suggesting the importance of PKC, and Erk1/2 signaling cascades in this response.	Tetradecanoylphorbol Acetate	33-36	intercellular adhesion molecule 1	Homo sapiens	0-6
1350288-6	1992	In contrast, CD4+ T cells from infected mice could be induced to proliferate by stimulation with PMA and ionomycin resulting in IL-2R up-regulation, IL-2 production, and proliferation.	Tetradecanoylphorbol Acetate	97-100	CD4 antigen	Mus musculus	13-16
17131377-6	2007	Interestingly, ICAM-1 expression in response to TPA-induced PKC activation was linked to the generation of reactive oxygen species (ROS), as pretreatment with NAC (an ROS scavenger) blocked both ErK1/2 activation and ICAM-1 expression induced by TPA.	Tetradecanoylphorbol Acetate	48-51	intercellular adhesion molecule 1	Homo sapiens	15-21
17131377-6	2007	Interestingly, ICAM-1 expression in response to TPA-induced PKC activation was linked to the generation of reactive oxygen species (ROS), as pretreatment with NAC (an ROS scavenger) blocked both ErK1/2 activation and ICAM-1 expression induced by TPA.	Tetradecanoylphorbol Acetate	48-51	X-linked Kx blood group	Homo sapiens	159-162
17131377-6	2007	Interestingly, ICAM-1 expression in response to TPA-induced PKC activation was linked to the generation of reactive oxygen species (ROS), as pretreatment with NAC (an ROS scavenger) blocked both ErK1/2 activation and ICAM-1 expression induced by TPA.	Tetradecanoylphorbol Acetate	48-51	intercellular adhesion molecule 1	Homo sapiens	217-223
17131377-6	2007	Interestingly, ICAM-1 expression in response to TPA-induced PKC activation was linked to the generation of reactive oxygen species (ROS), as pretreatment with NAC (an ROS scavenger) blocked both ErK1/2 activation and ICAM-1 expression induced by TPA.	Tetradecanoylphorbol Acetate	246-249	intercellular adhesion molecule 1	Homo sapiens	15-21
17131377-6	2007	Interestingly, ICAM-1 expression in response to TPA-induced PKC activation was linked to the generation of reactive oxygen species (ROS), as pretreatment with NAC (an ROS scavenger) blocked both ErK1/2 activation and ICAM-1 expression induced by TPA.	Tetradecanoylphorbol Acetate	246-249	X-linked Kx blood group	Homo sapiens	159-162
1350288-6	1992	In contrast, CD4+ T cells from infected mice could be induced to proliferate by stimulation with PMA and ionomycin resulting in IL-2R up-regulation, IL-2 production, and proliferation.	Tetradecanoylphorbol Acetate	97-100	interleukin 2 receptor, alpha chain	Mus musculus	128-133
17131377-7	2007	In addition, TPA-induced ICAM-1 expression was blocked by inhibition of nuclear factor-kappaB (NF-kappaB) activation following pretreatment with BAY11-7085 (a specific inhibitor of NF-kappaB activation).	Tetradecanoylphorbol Acetate	13-16	intercellular adhesion molecule 1	Homo sapiens	25-31
17131377-9	2007	Together, these observations demonstrated that TPA, a potent activator of PKC, induces ICAM-1 expression via a ROS- and ERK1/2-dependent signaling mechanism in ML-1 cells.	Tetradecanoylphorbol Acetate	47-50	intercellular adhesion molecule 1	Homo sapiens	87-93
1563479-7	1992	The pattern of vimentin mRNA accumulation in synchronized cultures after short-term TPA treatment strongly suggests that the cell cycle-dependent pattern of vimentin expression is caused, at least in part, by different levels of vimentin mRNA accumulated in the cells.	Tetradecanoylphorbol Acetate	84-87	vimentin	Mus musculus	157-165
1563479-7	1992	The pattern of vimentin mRNA accumulation in synchronized cultures after short-term TPA treatment strongly suggests that the cell cycle-dependent pattern of vimentin expression is caused, at least in part, by different levels of vimentin mRNA accumulated in the cells.	Tetradecanoylphorbol Acetate	84-87	vimentin	Mus musculus	157-165
1563479-8	1992	Since proteinaceous mediator(s) are obviously involved in TPA-induced vimentin expression in MPC-11 cells, cell cycle-dependent vimentin expression in these cells may be dependent on cell cycle-dependent regulation of the activity and/or concentration of such mediator(s).	Tetradecanoylphorbol Acetate	58-61	vimentin	Mus musculus	70-78
1563479-8	1992	Since proteinaceous mediator(s) are obviously involved in TPA-induced vimentin expression in MPC-11 cells, cell cycle-dependent vimentin expression in these cells may be dependent on cell cycle-dependent regulation of the activity and/or concentration of such mediator(s).	Tetradecanoylphorbol Acetate	58-61	vimentin	Mus musculus	128-136
17185330-3	2007	In human eosinophils studied in the perforated-patch configuration, phorbol myristate acetate (PMA) stimulation elicited NADPH oxidase-generated electron current (I(e)) and enhanced proton channel gating identically in the presence or absence of three specific cPLA(2)alpha inhibitors, Wyeth-1, pyrrolidine-2 and AACOCF(3) (arachidonyl trifluoromethyl ketone).	Tetradecanoylphorbol Acetate	68-93	phospholipase A2 group IVA	Homo sapiens	261-273
1321409-1	1992	Treatment of rat submandibular acinar cell extracts with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) caused the dose-dependent activation of protein kinase C (PKC), assessed by the phosphorylation of a novel and highly specific substrate.	Tetradecanoylphorbol Acetate	113-116	protein kinase C, gamma	Rattus norvegicus	158-174
17185330-3	2007	In human eosinophils studied in the perforated-patch configuration, phorbol myristate acetate (PMA) stimulation elicited NADPH oxidase-generated electron current (I(e)) and enhanced proton channel gating identically in the presence or absence of three specific cPLA(2)alpha inhibitors, Wyeth-1, pyrrolidine-2 and AACOCF(3) (arachidonyl trifluoromethyl ketone).	Tetradecanoylphorbol Acetate	95-98	phospholipase A2 group IVA	Homo sapiens	261-273
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	62-93	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-9
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	62-93	phospholipase A2 group IVA	Homo sapiens	174-200
17334233-3	2007	In this study, we show that phorbol myristate acetate (PMA) induces MMP-9 expression via a protein kinase Calpha (PKCalpha)-dependent signaling cascade in BEAS-2B human lung epithelial cells.	Tetradecanoylphorbol Acetate	28-53	matrix metallopeptidase 9	Homo sapiens	68-73
1321409-1	1992	Treatment of rat submandibular acinar cell extracts with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) caused the dose-dependent activation of protein kinase C (PKC), assessed by the phosphorylation of a novel and highly specific substrate.	Tetradecanoylphorbol Acetate	113-116	protein kinase C, gamma	Rattus norvegicus	176-179
1321409-3	1992	The TPA elevation of PKC was blocked by the PKC inhibitors H-7 and sangivamycin.	Tetradecanoylphorbol Acetate	4-7	protein kinase C, gamma	Rattus norvegicus	21-24
1321409-3	1992	The TPA elevation of PKC was blocked by the PKC inhibitors H-7 and sangivamycin.	Tetradecanoylphorbol Acetate	4-7	protein kinase C, gamma	Rattus norvegicus	44-47
1321409-4	1992	In intact cells, TPA caused the translocation of PKC from cytosol to membrane, consistent with its known mode of activation.	Tetradecanoylphorbol Acetate	17-20	protein kinase C, gamma	Rattus norvegicus	49-52
17334233-3	2007	In this study, we show that phorbol myristate acetate (PMA) induces MMP-9 expression via a protein kinase Calpha (PKCalpha)-dependent signaling cascade in BEAS-2B human lung epithelial cells.	Tetradecanoylphorbol Acetate	55-58	matrix metallopeptidase 9	Homo sapiens	68-73
1551880-9	1992	Phorbol myristate acetate (PMA), an activator of PKC, which did not affect [Ca2+]i, mimicked the actions of AGEPC, stimulating eicosanoid production and promoting tyrosine phosphorylation of a set of proteins similar to those phosphorylated following AGEPC stimulation.	Tetradecanoylphorbol Acetate	0-25	protein kinase C, gamma	Rattus norvegicus	49-52
17334233-4	2007	Pretreatment with either GF109203X, a general PKC inhibitor, or Go6976, a PKCalpha/beta isozyme inhibitor, inhibited PMA-induced activation of the MMP-9 promoter, as did transient transfection with PKCalpha antisense oligonuclotides.	Tetradecanoylphorbol Acetate	117-120	matrix metallopeptidase 9	Homo sapiens	147-152
17155946-4	2007	Phorbol-12-myristate 13-acetate (PMA)-stimulated EPCR shedding is reduced by approximately 50% in HEK293 cells transfected with human EPCR cDNA and by 60% in human umbilical vein endothelial cells after transfection of TACE small interfering RNA (siRNA) into these cells.	Tetradecanoylphorbol Acetate	33-36	ADAM metallopeptidase domain 17	Homo sapiens	219-223
1551880-9	1992	Phorbol myristate acetate (PMA), an activator of PKC, which did not affect [Ca2+]i, mimicked the actions of AGEPC, stimulating eicosanoid production and promoting tyrosine phosphorylation of a set of proteins similar to those phosphorylated following AGEPC stimulation.	Tetradecanoylphorbol Acetate	27-30	protein kinase C, gamma	Rattus norvegicus	49-52
16888805-0	2007	Interleukin-1beta and tetradecanoylphorbol acetate-induced biosynthesis of tumor necrosis factor alpha in human hepatoma cells involves the transcription factors ATF2 and c-Jun and stress-activated protein kinases.	Tetradecanoylphorbol Acetate	22-50	activating transcription factor 2	Homo sapiens	162-166
1315627-6	1992	Copper(II) bis(diisopropylsalicylate) (2 mumol 30 min before BSF), an effective inhibitor of TPA-induced ODC activity and tumor promotion, also had little or no effect on BSF-induced ODC.	Tetradecanoylphorbol Acetate	93-96	ornithine decarboxylase, structural 1	Mus musculus	105-108
16888805-0	2007	Interleukin-1beta and tetradecanoylphorbol acetate-induced biosynthesis of tumor necrosis factor alpha in human hepatoma cells involves the transcription factors ATF2 and c-Jun and stress-activated protein kinases.	Tetradecanoylphorbol Acetate	22-50	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	171-176
16888805-5	2007	Both IL-1beta and TPA triggered phosphorylation and activation of the basic region leucine zipper transcription factors c-Jun and ATF2 and expression of dominant-negative mutants of c-Jun and ATF2-reduced TNFalpha promoter activity and secretion of TNFalpha.	Tetradecanoylphorbol Acetate	18-21	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-125
16888805-5	2007	Both IL-1beta and TPA triggered phosphorylation and activation of the basic region leucine zipper transcription factors c-Jun and ATF2 and expression of dominant-negative mutants of c-Jun and ATF2-reduced TNFalpha promoter activity and secretion of TNFalpha.	Tetradecanoylphorbol Acetate	18-21	activating transcription factor 2	Homo sapiens	130-134
16888805-5	2007	Both IL-1beta and TPA triggered phosphorylation and activation of the basic region leucine zipper transcription factors c-Jun and ATF2 and expression of dominant-negative mutants of c-Jun and ATF2-reduced TNFalpha promoter activity and secretion of TNFalpha.	Tetradecanoylphorbol Acetate	18-21	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-187
16888805-5	2007	Both IL-1beta and TPA triggered phosphorylation and activation of the basic region leucine zipper transcription factors c-Jun and ATF2 and expression of dominant-negative mutants of c-Jun and ATF2-reduced TNFalpha promoter activity and secretion of TNFalpha.	Tetradecanoylphorbol Acetate	18-21	activating transcription factor 2	Homo sapiens	192-196
1315627-7	1992	The work described in this paper suggests that BSF induces epidermal ODC by a very specific mechanism that exhibits both similarities and differences with that of the phorbol ester, TPA.	Tetradecanoylphorbol Acetate	182-185	ornithine decarboxylase, structural 1	Mus musculus	69-72
1312452-2	1992	Activation of PKC by incubation for 4 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) resulted in a comparable dose-dependent decrease in 1,25-dihydroxyvitamin D3 binding in the osteoblast-like cell lines UMR 106 and ROS 17/2.8, with a maximum inhibition at 100 nM and an IC50 at 5 nM PMA.	Tetradecanoylphorbol Acetate	63-94	protein kinase C, gamma	Rattus norvegicus	14-17
17848742-8	2007	Zymography demonstrated secretion of MMP-2 by untreated human testis cancer cells and MMP-9 with PMA induction.	Tetradecanoylphorbol Acetate	97-100	matrix metallopeptidase 9	Homo sapiens	86-91
1312452-2	1992	Activation of PKC by incubation for 4 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) resulted in a comparable dose-dependent decrease in 1,25-dihydroxyvitamin D3 binding in the osteoblast-like cell lines UMR 106 and ROS 17/2.8, with a maximum inhibition at 100 nM and an IC50 at 5 nM PMA.	Tetradecanoylphorbol Acetate	96-99	protein kinase C, gamma	Rattus norvegicus	14-17
1312452-2	1992	Activation of PKC by incubation for 4 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) resulted in a comparable dose-dependent decrease in 1,25-dihydroxyvitamin D3 binding in the osteoblast-like cell lines UMR 106 and ROS 17/2.8, with a maximum inhibition at 100 nM and an IC50 at 5 nM PMA.	Tetradecanoylphorbol Acetate	300-303	protein kinase C, gamma	Rattus norvegicus	14-17
1312452-10	1992	The effect of activation of PKC on VDR is not a general effect, as PMA does not affect basal ornithine decarboxylase activity and potentiates PTH-induced ornithine decarboxylase activity.	Tetradecanoylphorbol Acetate	67-70	protein kinase C, gamma	Rattus norvegicus	28-31
1544377-2	1992	A 48-h exposure of murine plasmacytomas MPC-11 to the phorbol ester TPA reduces their growth and induces vimentin synthesis without affecting the composition of their nuclear lamina.	Tetradecanoylphorbol Acetate	68-71	vimentin	Mus musculus	105-113
17038313-9	2006	Consistently, beta-phorbol myristate acetate (PMA), but not 4alpha-PMA, induced a 3-fold stimulation of 32P incorporation into NCKX2 expressed in HEK293 cells.	Tetradecanoylphorbol Acetate	46-49	solute carrier family 24 member 2	Homo sapiens	127-132
1544380-6	1992	EGF and TPA reduced transiently the TSHr mRNA accumulation but did not suppress it.	Tetradecanoylphorbol Acetate	8-11	thyroid stimulating hormone receptor	Canis lupus familiaris	36-40
1560050-1	1992	EL 4-6.1 cells, variants of the murine EL4 thymoma cell line, can be activated by interleukin 1 (IL-1) or phorbol 12-myristate-13-acetate (PMA), or PMA+IL-1 to secrete interleukin 2 (IL-2) and interleukin 4 (IL-4) and to express the IL-2 receptor (IL-2R).	Tetradecanoylphorbol Acetate	139-142	interleukin 2 receptor, alpha chain	Mus musculus	233-246
16601754-3	2006	Depletion of GEF-H1 expression in D2 cells decreased RhoA activity and prevented PMA-induced contraction and apoptosis.	Tetradecanoylphorbol Acetate	81-84	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	13-19
16601754-6	2006	Given that GEF-H1 is inactivated when associated with microtubules and its release into cytosol due to depolymerization of microtubules activates RhoA, our results demonstrated that nonmicrotubule-associated GEF-H1 in D2 cells contributes to the sustained activation of RhoA/ROCK signaling in suspension cells, making cells susceptible to PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	339-342	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	11-17
16601754-6	2006	Given that GEF-H1 is inactivated when associated with microtubules and its release into cytosol due to depolymerization of microtubules activates RhoA, our results demonstrated that nonmicrotubule-associated GEF-H1 in D2 cells contributes to the sustained activation of RhoA/ROCK signaling in suspension cells, making cells susceptible to PMA-induced apoptosis.	Tetradecanoylphorbol Acetate	339-342	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	208-214
1560050-1	1992	EL 4-6.1 cells, variants of the murine EL4 thymoma cell line, can be activated by interleukin 1 (IL-1) or phorbol 12-myristate-13-acetate (PMA), or PMA+IL-1 to secrete interleukin 2 (IL-2) and interleukin 4 (IL-4) and to express the IL-2 receptor (IL-2R).	Tetradecanoylphorbol Acetate	139-142	interleukin 2 receptor, alpha chain	Mus musculus	248-253
1347710-6	1992	MoAbs GoH3 and 450-30, which bind the alpha 6 subunit of VLA-6, significantly reduced adherence of phorbol myristate acetate-stimulated PMNs to laminin-coated surfaces when CD11/CD18-independent adherence was blocked with anti-CD11/CD18 MoAbs.	Tetradecanoylphorbol Acetate	99-124	integrin subunit alpha 6	Homo sapiens	57-62
1515466-1	1992	A bispecific F(ab")2 monoclonal antibody which recognizes both the platelet GPIIb/IIIa receptor and human tissue plasminogen activator was produced to target tPA to platelets for enhancement of thrombolysis.	Tetradecanoylphorbol Acetate	158-161	integrin subunit alpha 2b	Homo sapiens	76-81
16787963-6	2006	In addition, SNAT2 expression in the mammary gland was induced by forskolin and PMA, inducers of PKA and PKC signaling pathways, respectively.	Tetradecanoylphorbol Acetate	80-83	solute carrier family 38, member 2	Rattus norvegicus	13-18
1370830-8	1992	Compared with R6-C1 cells, R6-PKC3 cells exhibited a 2-3-fold increase in the basal level of phosphorylation of MARCKS and after treatment with TPA, displayed a dramatic prolongation in phosphorylation of this protein.	Tetradecanoylphorbol Acetate	144-147	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	112-118
1370830-9	1992	Additionally, treatment of R6-PKC3 cells with TPA led to a prolonged increase in both the cytosolic and total cellular level of the MARCKS protein and a pronounced decrease in the level of MARCKS mRNA.	Tetradecanoylphorbol Acetate	46-49	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	132-138
16987710-1	2006	CD4+ and CD8+ lymphocyte cytokine production in patients with HIV/AIDS and Controls, in response to stimulation with phorbol-12-myristate-13-acetate (PMA) and ionomycin was assessed using single cell flow cytometric methods.	Tetradecanoylphorbol Acetate	117-148	CD8a molecule	Homo sapiens	9-12
1370830-9	1992	Additionally, treatment of R6-PKC3 cells with TPA led to a prolonged increase in both the cytosolic and total cellular level of the MARCKS protein and a pronounced decrease in the level of MARCKS mRNA.	Tetradecanoylphorbol Acetate	46-49	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	189-195
16987710-1	2006	CD4+ and CD8+ lymphocyte cytokine production in patients with HIV/AIDS and Controls, in response to stimulation with phorbol-12-myristate-13-acetate (PMA) and ionomycin was assessed using single cell flow cytometric methods.	Tetradecanoylphorbol Acetate	150-153	CD8a molecule	Homo sapiens	9-12
1347198-3	1992	We probed the involvement of protein kinase function and intracellular calcium ion upon ICAM-1 expression of human umbilical vein endothelial cells activated alternatively by TNF-alpha, IL-1 beta, LPS, or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	205-236	intercellular adhesion molecule 1	Homo sapiens	88-94
1310905-2	1992	In human erythrocyte membranes, membrane binding of spin-labeled TPA-analogous phorbol (doxyl)esters [(n,m)PA] was investigated during measurement of the kinetics of the decay of their electron paramagnetic resonance signal by ascorbate reduction.	Tetradecanoylphorbol Acetate	65-68	spindlin 1	Homo sapiens	52-56
16934760-5	2006	In the present study, a library of analogs of curcumin was screened for activity against the TPA-induced activation of AP-1 using the Panomics AP-1 Reporter 293 stable cell line which is designed for screening potential inhibitors.	Tetradecanoylphorbol Acetate	93-96	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	119-123
16934760-5	2006	In the present study, a library of analogs of curcumin was screened for activity against the TPA-induced activation of AP-1 using the Panomics AP-1 Reporter 293 stable cell line which is designed for screening potential inhibitors.	Tetradecanoylphorbol Acetate	93-96	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	143-147
16934760-8	2006	In addition, a number of analogs were identified that enhanced the TPA-induced activation of AP-1.	Tetradecanoylphorbol Acetate	67-70	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-97
1544398-5	1992	Both concanavalin A (ConA) and the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA) induce GM-CSF expression in EL-4 cells.	Tetradecanoylphorbol Acetate	50-86	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	100-106
1544398-5	1992	Both concanavalin A (ConA) and the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA) induce GM-CSF expression in EL-4 cells.	Tetradecanoylphorbol Acetate	88-91	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	100-106
1544398-6	1992	However, the biological activity of GM-CSF in the supernatants of the TPA-stimulated cells was higher than that of ConA-stimulated cells.	Tetradecanoylphorbol Acetate	70-73	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	36-42
1544398-10	1992	Actinomycin D chase experiments show that ConA increases the GM-CSF mRNA half-life from less than 30 to 90 min, whereas TPA prolongs it to greater than 3 h. These results indicate that GM-CSF mRNA induction by ConA (in common with TPA) is regulated predominantly via RNA stabilization and that the difference in prolongation of the mRNA half-life provides the primary explanation for the lower levels of GM-CSF mRNA induced by ConA compared to TPA.	Tetradecanoylphorbol Acetate	120-123	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	185-191
16854530-2	2006	Previously we showed that the expression of MDR3 mRNA was down-regulated by phorbol 12-myristate 13-acetate (PMA) in human Chang liver cells.	Tetradecanoylphorbol Acetate	76-107	ATP binding cassette subfamily B member 4	Homo sapiens	44-48
18387645-2	2008	JWA, a novel retinoic acid-inducible gene, is known to be involved in apoptosis induced by various agents, for example, 12-O-tetradecanoylphorbol 13-acetate, N-4-hydroxy-phenyl-retinamide and arsenic trioxide.	Tetradecanoylphorbol Acetate	120-156	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	0-3
16854530-2	2006	Previously we showed that the expression of MDR3 mRNA was down-regulated by phorbol 12-myristate 13-acetate (PMA) in human Chang liver cells.	Tetradecanoylphorbol Acetate	109-112	ATP binding cassette subfamily B member 4	Homo sapiens	44-48
1544398-10	1992	Actinomycin D chase experiments show that ConA increases the GM-CSF mRNA half-life from less than 30 to 90 min, whereas TPA prolongs it to greater than 3 h. These results indicate that GM-CSF mRNA induction by ConA (in common with TPA) is regulated predominantly via RNA stabilization and that the difference in prolongation of the mRNA half-life provides the primary explanation for the lower levels of GM-CSF mRNA induced by ConA compared to TPA.	Tetradecanoylphorbol Acetate	120-123	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	185-191
18356551-7	2008	Moreover, FVB.LDLR-/- macrophages showed 5-fold increased PMA-induced shedding of tumor necrosis factor (TNF)-alpha and 32% increased release of TNF-receptor I compared to B6.LDLR-/-.	Tetradecanoylphorbol Acetate	58-61	low density lipoprotein receptor	Mus musculus	14-18
1544398-10	1992	Actinomycin D chase experiments show that ConA increases the GM-CSF mRNA half-life from less than 30 to 90 min, whereas TPA prolongs it to greater than 3 h. These results indicate that GM-CSF mRNA induction by ConA (in common with TPA) is regulated predominantly via RNA stabilization and that the difference in prolongation of the mRNA half-life provides the primary explanation for the lower levels of GM-CSF mRNA induced by ConA compared to TPA.	Tetradecanoylphorbol Acetate	231-234	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	185-191
18356551-7	2008	Moreover, FVB.LDLR-/- macrophages showed 5-fold increased PMA-induced shedding of tumor necrosis factor (TNF)-alpha and 32% increased release of TNF-receptor I compared to B6.LDLR-/-.	Tetradecanoylphorbol Acetate	58-61	low density lipoprotein receptor	Mus musculus	175-179
1544398-10	1992	Actinomycin D chase experiments show that ConA increases the GM-CSF mRNA half-life from less than 30 to 90 min, whereas TPA prolongs it to greater than 3 h. These results indicate that GM-CSF mRNA induction by ConA (in common with TPA) is regulated predominantly via RNA stabilization and that the difference in prolongation of the mRNA half-life provides the primary explanation for the lower levels of GM-CSF mRNA induced by ConA compared to TPA.	Tetradecanoylphorbol Acetate	231-234	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	185-191
1544398-10	1992	Actinomycin D chase experiments show that ConA increases the GM-CSF mRNA half-life from less than 30 to 90 min, whereas TPA prolongs it to greater than 3 h. These results indicate that GM-CSF mRNA induction by ConA (in common with TPA) is regulated predominantly via RNA stabilization and that the difference in prolongation of the mRNA half-life provides the primary explanation for the lower levels of GM-CSF mRNA induced by ConA compared to TPA.	Tetradecanoylphorbol Acetate	231-234	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	185-191
1544398-10	1992	Actinomycin D chase experiments show that ConA increases the GM-CSF mRNA half-life from less than 30 to 90 min, whereas TPA prolongs it to greater than 3 h. These results indicate that GM-CSF mRNA induction by ConA (in common with TPA) is regulated predominantly via RNA stabilization and that the difference in prolongation of the mRNA half-life provides the primary explanation for the lower levels of GM-CSF mRNA induced by ConA compared to TPA.	Tetradecanoylphorbol Acetate	231-234	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	185-191
16887814-5	2006	Both P1 and P2 can be regulated by phorbol ester (12-O-tetradecanoylphorbol-13-acetate) and calcium ionophore (A23187).	Tetradecanoylphorbol Acetate	50-86	crystallin gamma F, pseudogene	Homo sapiens	5-14
1309563-5	1992	The PKC activator phorbol 12-myristate 13-acetate (PMA) stimulated c-fos expression but did not trigger cell proliferation.	Tetradecanoylphorbol Acetate	18-49	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	67-72
1549353-2	1992	Both smg p21A mRNA and smg p21B mRNA were detected in CMK, a human megakaryocytic leukemia cell line, and their levels were markedly elevated by treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), which caused the differentiation of this cell line into more mature megakaryocytes.	Tetradecanoylphorbol Acetate	160-197	cytidine/uridine monophosphate kinase 1	Homo sapiens	54-57
18413234-7	2008	Activation of Ras guanine nucleotide releasing proteins (RasGRPs) by phorbol 12-myristate 13-acetate (PMA) or downregulation of Gal-3 by Gal-3 shRNA increased the levels of N-Ras-GTP in Gal-3 expressing cells.	Tetradecanoylphorbol Acetate	69-100	NRAS proto-oncogene, GTPase	Homo sapiens	173-178
1549353-3	1992	The smg p21 protein molecules also increased during the TPA-induced differentiation of CMK cells.	Tetradecanoylphorbol Acetate	56-59	cytidine/uridine monophosphate kinase 1	Homo sapiens	87-90
18413234-7	2008	Activation of Ras guanine nucleotide releasing proteins (RasGRPs) by phorbol 12-myristate 13-acetate (PMA) or downregulation of Gal-3 by Gal-3 shRNA increased the levels of N-Ras-GTP in Gal-3 expressing cells.	Tetradecanoylphorbol Acetate	102-105	NRAS proto-oncogene, GTPase	Homo sapiens	173-178
16814409-7	2006	In MCF7 cells, where the ERK pathway is inactivated and MMPs are not secreted and the ERK pathway can be activated by PMA, the PMA-induced ERK phosphorylation was reduced by the expression of rpS3.	Tetradecanoylphorbol Acetate	118-121	ribosomal protein S3	Homo sapiens	192-196
1549353-5	1992	Ha-ras p21 mRNA was undetectable, but both Ki- and N-ras p21 mRNAs were detected in CMK cells and their levels were also increased during TPA-induced differentiation of CMK cells, although to a lesser extent than those of smg p21 mRNAs.	Tetradecanoylphorbol Acetate	138-141	cytidine/uridine monophosphate kinase 1	Homo sapiens	84-87
1549353-5	1992	Ha-ras p21 mRNA was undetectable, but both Ki- and N-ras p21 mRNAs were detected in CMK cells and their levels were also increased during TPA-induced differentiation of CMK cells, although to a lesser extent than those of smg p21 mRNAs.	Tetradecanoylphorbol Acetate	138-141	cytidine/uridine monophosphate kinase 1	Homo sapiens	169-172
1310017-6	1992	Pretreatment of these cells with H-7, a PKC inhibitor, released the endothelin and PMA-mediated attenuation of ANF-stimulated cGMP formation.	Tetradecanoylphorbol Acetate	83-86	natriuretic peptide A	Rattus norvegicus	111-114
16893987-9	2006	Pretreatment of the cells with phorbol myristate acetate to enhance ERK activation reduced p40 production in response to the optimal LPS stimulation.	Tetradecanoylphorbol Acetate	31-56	interleukin 12b	Mus musculus	91-94
19688047-6	2008	RESULTS: The pharmacological PKC activator phorbol-12-myristate-13-acetate (PMA) and platelet-derived growth factor (PDGF) were able to induce the activation of Raf-1 kinase in the v-H-ras-transformed NIH3T3 fibroblasts.	Tetradecanoylphorbol Acetate	43-74	v-raf-leukemia viral oncogene 1	Mus musculus	161-166
19688047-6	2008	RESULTS: The pharmacological PKC activator phorbol-12-myristate-13-acetate (PMA) and platelet-derived growth factor (PDGF) were able to induce the activation of Raf-1 kinase in the v-H-ras-transformed NIH3T3 fibroblasts.	Tetradecanoylphorbol Acetate	76-79	v-raf-leukemia viral oncogene 1	Mus musculus	161-166
1730238-1	1992	The CDw50 antigen is a constitutively non-phosphorylated leukocyte surface molecule which becomes highly phosphorylated in all the normal and lymphoblastoid cells analyzed (peripheral blood mononuclear cells, Molt 4, CEM, 8402, Namalwa), after stimulation with tumor promoter agents (phorbol 12-myristate 13-acetate, phorbol 12,13-dibutyrate, mezerein).	Tetradecanoylphorbol Acetate	284-315	intercellular adhesion molecule 3	Homo sapiens	4-9
18248623-1	2008	We examined the mechanisms involved in protein kinase C (PKC)-dependent down-regulation of dopamine transporter (DAT) activity and cell surface expression by treating heterologously expressing cells with the clathrin-mediated endocytosis inhibitor concanavalin A (Con A) or the cholesterol depleter/membrane raft disrupter methyl-beta-cyclodextrin (MbetaC) prior to treatment with the PKC activator phorbol 12-myristate, 13-acetate (PMA).	Tetradecanoylphorbol Acetate	433-436	solute carrier family 6 member 3	Homo sapiens	113-116
16762451-6	2006	HT-29/DCC cells show no changes in adherent junctions but upon treatment with TPA, HT-29/DCC cells show resistance to scattering, and maintain E-cadherin in the membrane.	Tetradecanoylphorbol Acetate	78-81	DCC netrin 1 receptor	Homo sapiens	6-9
16762451-6	2006	HT-29/DCC cells show no changes in adherent junctions but upon treatment with TPA, HT-29/DCC cells show resistance to scattering, and maintain E-cadherin in the membrane.	Tetradecanoylphorbol Acetate	78-81	DCC netrin 1 receptor	Homo sapiens	89-92
1738590-1	1992	The TPA-inducible transcription factor AP-1, consisting of homo- or hetero-dimers of members of the Jun- and Fos-families, regulates transcription of a wide variety of genes containing the TPA response element (TRE).	Tetradecanoylphorbol Acetate	4-7	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-43
16607034-6	2006	Dibutyryl cyclic AMP and phorbol 12-myristate 13-acetate, which differentiate apoA-I-mediated cellular lipid release between 293/2c and 293/6c, also exhibited the same differential effects on the SAA-mediated reactions.	Tetradecanoylphorbol Acetate	25-56	serum amyloid A1 cluster	Homo sapiens	196-199
16613841-7	2006	Phorbol 12-myristate 13-acetate (PMA) switches on DKF-1 catalytic activity in situ by promoting phosphorylation of a single amino acid Thr(588) in the activation loop.	Tetradecanoylphorbol Acetate	0-31	Serine/threonine-protein kinase dkf-1	Caenorhabditis elegans	50-55
18435488-3	2008	Our study delineates a unique brain endothelial phenotype in that MMP-9 secretion is increased upon phorbol 12-myristate 13-acetate (PMA) treatment of HBMEC.	Tetradecanoylphorbol Acetate	100-131	matrix metallopeptidase 9	Homo sapiens	66-71
18435488-3	2008	Our study delineates a unique brain endothelial phenotype in that MMP-9 secretion is increased upon phorbol 12-myristate 13-acetate (PMA) treatment of HBMEC.	Tetradecanoylphorbol Acetate	133-136	matrix metallopeptidase 9	Homo sapiens	66-71
18339327-2	2008	To determine whether a Neu3 is able to modulate megakaryocytic differentiation of K562 cells, we studied the functional significance of human Neu3 induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	158-189	neuraminidase 3	Homo sapiens	142-146
18339327-2	2008	To determine whether a Neu3 is able to modulate megakaryocytic differentiation of K562 cells, we studied the functional significance of human Neu3 induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	191-194	neuraminidase 3	Homo sapiens	142-146
1738590-1	1992	The TPA-inducible transcription factor AP-1, consisting of homo- or hetero-dimers of members of the Jun- and Fos-families, regulates transcription of a wide variety of genes containing the TPA response element (TRE).	Tetradecanoylphorbol Acetate	4-7	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	109-112
18339327-5	2008	Neu3 overexpression inhibited the PMA-induced ERK1/2 and p38 MAPK phosphorylation in the K562 cells.	Tetradecanoylphorbol Acetate	34-37	neuraminidase 3	Homo sapiens	0-4
1738590-1	1992	The TPA-inducible transcription factor AP-1, consisting of homo- or hetero-dimers of members of the Jun- and Fos-families, regulates transcription of a wide variety of genes containing the TPA response element (TRE).	Tetradecanoylphorbol Acetate	189-192	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-43
18483307-4	2008	MCF-7 cells overexpressing HO-1 (MCF-7/HO-1) were established in the present study, and TPA-induced MMP-9 gene expression, tumor invasion, and colony formation were significantly reduced in MCF-7/HO-1 cells, compared with those in Neo-transfected cells.	Tetradecanoylphorbol Acetate	88-91	matrix metallopeptidase 9	Homo sapiens	100-105
16613841-7	2006	Phorbol 12-myristate 13-acetate (PMA) switches on DKF-1 catalytic activity in situ by promoting phosphorylation of a single amino acid Thr(588) in the activation loop.	Tetradecanoylphorbol Acetate	33-36	Serine/threonine-protein kinase dkf-1	Caenorhabditis elegans	50-55
18483307-6	2008	Additionally, the addition of carbon monoxide, but not ferric ions, biliverdin, or bilirubin, inhibited TPA-induced invasion through suppressing MMP-9, extracellular signal-regulated kinases, and AP-1 activation stimulated by TPA.	Tetradecanoylphorbol Acetate	104-107	matrix metallopeptidase 9	Homo sapiens	145-150
1738590-1	1992	The TPA-inducible transcription factor AP-1, consisting of homo- or hetero-dimers of members of the Jun- and Fos-families, regulates transcription of a wide variety of genes containing the TPA response element (TRE).	Tetradecanoylphorbol Acetate	189-192	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	109-112
16613842-7	2006	Mutations at a "Pro(11)" position in C1 domains were inactivating; kinase activity was minimal at PMA concentrations that stimulated wild type DKF-1 approximately 10-fold.	Tetradecanoylphorbol Acetate	98-101	Serine/threonine-protein kinase dkf-1	Caenorhabditis elegans	143-148
16613842-8	2006	DKF-1 mutants exhibited unchanged, maximum kinase activity after cells were incubated with high PMA concentrations.	Tetradecanoylphorbol Acetate	96-99	Serine/threonine-protein kinase dkf-1	Caenorhabditis elegans	0-5
1521167-2	1992	The mechanism of ornithine decarboxylase (ODC) induction by phorbol ester (TPA) has been studied in two permanent epithelial cell lines, a control (Ctr) and a Benzo (a) pyrene transformed line (BaP-tr); the degree of ODC gene expression (ODC-mRNA) was evaluated in comparison to the ODC activity.	Tetradecanoylphorbol Acetate	75-78	ornithine decarboxylase, structural 1	Mus musculus	17-40
16713561-4	2006	Cyld-/- tumors and keratinocytes treated with 12-O-tetradecanoylphorbol-13 acetate (TPA) or UV light are hyperproliferative and have elevated cyclin D1 levels.	Tetradecanoylphorbol Acetate	46-82	cyclin D1	Mus musculus	142-151
16713561-4	2006	Cyld-/- tumors and keratinocytes treated with 12-O-tetradecanoylphorbol-13 acetate (TPA) or UV light are hyperproliferative and have elevated cyclin D1 levels.	Tetradecanoylphorbol Acetate	84-87	cyclin D1	Mus musculus	142-151
16713561-6	2006	In Cyld+/+ keratinocytes, TPA or UV light triggers the translocation of Cyld from the cytoplasm to the perinuclear region, where Cyld binds and deubiquitinates Bcl-3, thereby preventing nuclear accumulation of Bcl-3 and p50/Bcl-3- or p52/Bcl-3-dependent proliferation.	Tetradecanoylphorbol Acetate	26-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100	Mus musculus	234-237
1521167-2	1992	The mechanism of ornithine decarboxylase (ODC) induction by phorbol ester (TPA) has been studied in two permanent epithelial cell lines, a control (Ctr) and a Benzo (a) pyrene transformed line (BaP-tr); the degree of ODC gene expression (ODC-mRNA) was evaluated in comparison to the ODC activity.	Tetradecanoylphorbol Acetate	75-78	ornithine decarboxylase, structural 1	Mus musculus	42-45
1521167-3	1992	A small dose of TPA (4 x 10(-8) M) highly induced ODC activity in these cells.	Tetradecanoylphorbol Acetate	16-19	ornithine decarboxylase, structural 1	Mus musculus	50-53
15993536-5	2006	Separately, SF inhibited TPA-induced ornithine decarboxylase activity in mouse skin, an obligate step in TPA-induced promotion of carcinogenesis.	Tetradecanoylphorbol Acetate	25-28	ornithine decarboxylase, structural 1	Mus musculus	37-60
1521167-6	1992	Repetitive TPA treatment decreased the ODC induction in these cells, as compared to that resulting from a single TPA treatment.	Tetradecanoylphorbol Acetate	11-14	ornithine decarboxylase, structural 1	Mus musculus	39-42
15993536-5	2006	Separately, SF inhibited TPA-induced ornithine decarboxylase activity in mouse skin, an obligate step in TPA-induced promotion of carcinogenesis.	Tetradecanoylphorbol Acetate	105-108	ornithine decarboxylase, structural 1	Mus musculus	37-60
1521167-14	1992	Studies now in progress suggested that the inhibition of TPA induced ODC by DXME may reflect ODC gene repression, as for the stimulating effect it could be related to ODC post-transcriptional modulation, owing to the decrease of proteolytic action.	Tetradecanoylphorbol Acetate	57-60	ornithine decarboxylase, structural 1	Mus musculus	69-72
1521167-14	1992	Studies now in progress suggested that the inhibition of TPA induced ODC by DXME may reflect ODC gene repression, as for the stimulating effect it could be related to ODC post-transcriptional modulation, owing to the decrease of proteolytic action.	Tetradecanoylphorbol Acetate	57-60	ornithine decarboxylase, structural 1	Mus musculus	93-96
1521167-14	1992	Studies now in progress suggested that the inhibition of TPA induced ODC by DXME may reflect ODC gene repression, as for the stimulating effect it could be related to ODC post-transcriptional modulation, owing to the decrease of proteolytic action.	Tetradecanoylphorbol Acetate	57-60	ornithine decarboxylase, structural 1	Mus musculus	93-96
16651411-6	2006	Mutation of the activator protein 1 (AP-1) binding site abrogated the TPA-induced transcriptional response of the luciferase reporter gene under the control of the TFF1 promoter, showing the requirement for the AP-1 site.	Tetradecanoylphorbol Acetate	70-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	16-35
16651411-6	2006	Mutation of the activator protein 1 (AP-1) binding site abrogated the TPA-induced transcriptional response of the luciferase reporter gene under the control of the TFF1 promoter, showing the requirement for the AP-1 site.	Tetradecanoylphorbol Acetate	70-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-41
16651411-6	2006	Mutation of the activator protein 1 (AP-1) binding site abrogated the TPA-induced transcriptional response of the luciferase reporter gene under the control of the TFF1 promoter, showing the requirement for the AP-1 site.	Tetradecanoylphorbol Acetate	70-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	211-215
1395075-6	1992	In both cell types, serum-induced 3H-thymidine incorporation was enhanced by PKC down-regulation, which was obtained by prolonged treatment of cells with high dose of TPA, whereas it was inhibited in a dose-dependent manner by activation of the enzyme.	Tetradecanoylphorbol Acetate	167-170	protein kinase C, gamma	Rattus norvegicus	77-80
1395075-8	1992	Our results indicate therefore i) that in the presence of serum PKC exerts an antiproliferative effect in rat aortic fibroblasts and ii) that the increase in PKC activity and in sensitivity to TPA exhibited by SHR-derived fibroblasts, is not involved in the increased proliferation rate displayed by SHR-derived fibroblasts in serum-containing medium.	Tetradecanoylphorbol Acetate	193-196	protein kinase C, gamma	Rattus norvegicus	64-67
1521461-5	1992	12-O-Tetradecanoylphorbol-13-acetate (TPA)-responsive element-like sequences have been identified in upstream regions of the GST-P gene, and oncogene products c-jun and c-fos are suggested to activate the gene.	Tetradecanoylphorbol Acetate	0-36	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	169-174
1521461-5	1992	12-O-Tetradecanoylphorbol-13-acetate (TPA)-responsive element-like sequences have been identified in upstream regions of the GST-P gene, and oncogene products c-jun and c-fos are suggested to activate the gene.	Tetradecanoylphorbol Acetate	38-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	169-174
16803512-5	2006	Untreated DoTc2 4510 cells showed MMP-9 expression, which was enhanced with phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	76-107	matrix metallopeptidase 9	Homo sapiens	34-39
1730747-15	1992	In the present report, we show that heparin selectively repressed TPA-inducible AP-1-mediated gene expression.	Tetradecanoylphorbol Acetate	66-69	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-84
1662217-5	1991	Kinase assays in myelin basic protein (MBP)-containing gel, after SDS-polyacrylamide gel electrophoresis, revealed that insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated MBP kinase activity in alpha Y91 immunoprecipitates comigrated at molecular mass 42 and 44 kDa.	Tetradecanoylphorbol Acetate	131-167	myelin basic protein	Oryctolagus cuniculus	17-37
16618982-7	2006	Although phorbol 12-myristate 13-acetate treatment increased phosphorylation of MARCKS and activated MAP kinase, it did not activate the FS promoter.	Tetradecanoylphorbol Acetate	9-40	myristoylated alanine rich protein kinase C substrate	Mus musculus	80-86
1662217-5	1991	Kinase assays in myelin basic protein (MBP)-containing gel, after SDS-polyacrylamide gel electrophoresis, revealed that insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated MBP kinase activity in alpha Y91 immunoprecipitates comigrated at molecular mass 42 and 44 kDa.	Tetradecanoylphorbol Acetate	169-172	myelin basic protein	Oryctolagus cuniculus	17-37
1662217-16	1991	These data also demonstrate that insulin and TPA activate MBP/MAP2 kinase activity by de novo phosphorylation of threonine and tyrosine residues via a very similar pathway.	Tetradecanoylphorbol Acetate	45-48	microtubule-associated protein 2	Oryctolagus cuniculus	62-66
1662619-9	1991	The data suggest that epidermal phospholipase A2 activity can be stimulated by bradykinin via a B2 receptor-G-protein-dependent pathway, which is independent of PKC and a PKC-dependent pathway which is activated by phorbol esters such as PMA.	Tetradecanoylphorbol Acetate	238-241	phospholipase A2, group IB, pancreas	Mus musculus	32-48
17075289-7	2006	RESULTS: We detected the de novo synthesis of MMP-9 in HCMC after stimulation with PMA and found that the synthesis was mediated through protein kinase C-mitogen activated protein kinase kinase (MEK)-ERK pathway.	Tetradecanoylphorbol Acetate	83-86	matrix metallopeptidase 9	Homo sapiens	46-51
17075289-8	2006	The MMP-9 production induced by PMA was suppressed by simultaneous treatment with A23187, whereas GM-CSF production was potentiated.	Tetradecanoylphorbol Acetate	32-35	matrix metallopeptidase 9	Homo sapiens	4-9
1744120-4	1991	Moreover, the effects of phorbol 12-myristate 13-acetate (PMA) and insulin were additive in the induction of ET-1 gene expression.	Tetradecanoylphorbol Acetate	25-56	endothelin 1	Bos taurus	109-113
1744120-4	1991	Moreover, the effects of phorbol 12-myristate 13-acetate (PMA) and insulin were additive in the induction of ET-1 gene expression.	Tetradecanoylphorbol Acetate	58-61	endothelin 1	Bos taurus	109-113
16673205-6	2006	12-O-tetradecanoylphorbol-13-acetate (TPA), a direct activator VEGF synthesis induced by PKC, was inhibited by minodronate.	Tetradecanoylphorbol Acetate	0-36	vascular endothelial growth factor A	Mus musculus	63-67
16673205-6	2006	12-O-tetradecanoylphorbol-13-acetate (TPA), a direct activator VEGF synthesis induced by PKC, was inhibited by minodronate.	Tetradecanoylphorbol Acetate	38-41	vascular endothelial growth factor A	Mus musculus	63-67
1744120-5	1991	When protein kinase C in the bovine aortic endothelial cells was down-regulated by preincubation with 8 x 10(-7) M PMA for 24 or 48 h, insulin was still able to increase ET-1 mRNA levels whereas PMA was ineffective.	Tetradecanoylphorbol Acetate	115-118	endothelin 1	Bos taurus	170-174
16673205-7	2006	Minodronate inhibited Raf-1, MEK1/2 and p44/p42 MAP kinase phosphorylation induced by TPA.	Tetradecanoylphorbol Acetate	86-89	v-raf-leukemia viral oncogene 1	Mus musculus	22-27
1722647-7	1991	Preincubation of acini with 12-O-tetradecanoylphorbol 12,13-acetate (TPA, 1 microM), an activator of protein kinase C (PKC), decreased subsequent CCK-8-stimulated amylase release, and total binding of 125I-BH-CCK-8 to a similar extent as with pretreatment with CCh.	Tetradecanoylphorbol Acetate	69-72	cholecystokinin	Rattus norvegicus	146-149
1722647-7	1991	Preincubation of acini with 12-O-tetradecanoylphorbol 12,13-acetate (TPA, 1 microM), an activator of protein kinase C (PKC), decreased subsequent CCK-8-stimulated amylase release, and total binding of 125I-BH-CCK-8 to a similar extent as with pretreatment with CCh.	Tetradecanoylphorbol Acetate	69-72	cholecystokinin	Rattus norvegicus	209-212
16516815-6	2006	mRNA of all enzymes were present in cultured HEK and HaCaT cells, but the prominent induction of CYP4F8 mRNA in psoriasis could not be mimicked by treatment of these keratinocytes with a mixture of inflammatory cytokines or with phorbol 12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	229-260	cytochrome P450 family 4 subfamily F member 8	Homo sapiens	97-103
1722647-8	1991	The inhibitory effect of TPA or CCh on CCK-8-stimulated amylase release was reversed by simultaneous preincubation with H-7, an inhibitor of PKC.	Tetradecanoylphorbol Acetate	25-28	cholecystokinin	Rattus norvegicus	39-42
1722647-10	1991	After CCh or TPA preincubation, CCK-8-stimulated production of [3H]inositol phosphates was inhibited by at least 49%.	Tetradecanoylphorbol Acetate	13-16	cholecystokinin	Rattus norvegicus	32-35
1819689-1	1991	When rat pleural mononuclear leukocytes were stimulated with 1 microM phorbol myristate acetate (PMA), platelet-activating factor (PAF)-like activity was detected in the supernatant and the cellular fractions of the incubation mixture, as measured by rabbit platelet aggregation.	Tetradecanoylphorbol Acetate	70-95	PCNA clamp associated factor	Rattus norvegicus	131-134
16330529-5	2006	Similarly, activation of PKC with phorbol 12-myristate 13-acetate (PMA) depressed LPS-stimulated IL-12p40 secretion, and depletion of PKC augmented LPS-stimulated IL-12p40 secretion.	Tetradecanoylphorbol Acetate	34-65	interleukin 12b	Mus musculus	97-105
16330529-5	2006	Similarly, activation of PKC with phorbol 12-myristate 13-acetate (PMA) depressed LPS-stimulated IL-12p40 secretion, and depletion of PKC augmented LPS-stimulated IL-12p40 secretion.	Tetradecanoylphorbol Acetate	67-70	interleukin 12b	Mus musculus	97-105
16424000-2	2006	We reported that FVB/N transgenic mice that overexpress ( approximately 8-fold) PKCdelta protein in basal epidermal cells and cells of the hair follicle are resistant to the development of both skin papillomas and squamous cell carcinoma (SCC) elicited by 7,12-dimethylbenz(a)anthracene initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion protocol.	Tetradecanoylphorbol Acetate	302-338	protein kinase C, delta	Mus musculus	80-88
1819689-1	1991	When rat pleural mononuclear leukocytes were stimulated with 1 microM phorbol myristate acetate (PMA), platelet-activating factor (PAF)-like activity was detected in the supernatant and the cellular fractions of the incubation mixture, as measured by rabbit platelet aggregation.	Tetradecanoylphorbol Acetate	97-100	PCNA clamp associated factor	Rattus norvegicus	131-134
1944268-3	1991	Saturation mutagenesis of the CLE0 element indicates that in addition to the previously mapped region between -73 and -91 (CLE2+ GC box), the CLE0 element is necessary for induction of the mouse GM-CSF gene by phorbol myristate acetate/Ca ionophore (A23187) stimulation in T cells.	Tetradecanoylphorbol Acetate	210-235	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	195-201
16424000-2	2006	We reported that FVB/N transgenic mice that overexpress ( approximately 8-fold) PKCdelta protein in basal epidermal cells and cells of the hair follicle are resistant to the development of both skin papillomas and squamous cell carcinoma (SCC) elicited by 7,12-dimethylbenz(a)anthracene initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion protocol.	Tetradecanoylphorbol Acetate	340-343	protein kinase C, delta	Mus musculus	80-88
16424000-5	2006	PKCdelta overexpression in transgenic mice enhanced TPA-induced but not UVR-induced apoptosis and suppressed TPA-stimulated but not UVR-stimulated levels of cell PCNA, cytokines (TNF-alpha, G-CSF, and GM-CSF), and the expression of COX-2, p-Akt, and p38.	Tetradecanoylphorbol Acetate	52-55	protein kinase C, delta	Mus musculus	0-8
16424000-5	2006	PKCdelta overexpression in transgenic mice enhanced TPA-induced but not UVR-induced apoptosis and suppressed TPA-stimulated but not UVR-stimulated levels of cell PCNA, cytokines (TNF-alpha, G-CSF, and GM-CSF), and the expression of COX-2, p-Akt, and p38.	Tetradecanoylphorbol Acetate	109-112	protein kinase C, delta	Mus musculus	0-8
1816077-3	1991	Epidermal hyperplasia induced on exposure of S/RV Cri mouse skin to a single or multiple TPA application after MCA injection was associated with a significant increase in the thickness of nucleated cell layers, stratum granulosum, number of suprabasal cells and dark basal cells.	Tetradecanoylphorbol Acetate	89-92	cribriform degeneration	Mus musculus	50-53
16424000-7	2006	The proapoptotic activity of PKCdelta coupled with its ability to suppress TPA-induced expression of proinflammatory cytokines, COX-2 expression, and the phosphorylation of Akt and p38 may play roles in the suppression of TPA-promoted development of SCC.	Tetradecanoylphorbol Acetate	75-78	protein kinase C, delta	Mus musculus	29-37
16424000-7	2006	The proapoptotic activity of PKCdelta coupled with its ability to suppress TPA-induced expression of proinflammatory cytokines, COX-2 expression, and the phosphorylation of Akt and p38 may play roles in the suppression of TPA-promoted development of SCC.	Tetradecanoylphorbol Acetate	222-225	protein kinase C, delta	Mus musculus	29-37
1801783-5	1991	Depletion of PKC by prolonged TPA treatment resulted in inhibition of c-jun expression.	Tetradecanoylphorbol Acetate	30-33	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	70-75
16319225-5	2005	In primary CD8(+) T cells, which express only TR2 and TR4 and are resistant to TRAIL-induced apoptosis, stimulation with phorbol myristate acetate abrogated the ligand-independent interaction between TR2 and TR4 and enhanced their sensitivity to TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	121-146	CD8a molecule	Homo sapiens	11-14
16319225-5	2005	In primary CD8(+) T cells, which express only TR2 and TR4 and are resistant to TRAIL-induced apoptosis, stimulation with phorbol myristate acetate abrogated the ligand-independent interaction between TR2 and TR4 and enhanced their sensitivity to TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	121-146	taste 1 receptor member 2	Homo sapiens	46-49
16319225-5	2005	In primary CD8(+) T cells, which express only TR2 and TR4 and are resistant to TRAIL-induced apoptosis, stimulation with phorbol myristate acetate abrogated the ligand-independent interaction between TR2 and TR4 and enhanced their sensitivity to TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	121-146	TNF receptor superfamily member 10d	Homo sapiens	54-57
1659379-6	1991	On exposure to PMA a complete depletion of PKC-alpha is observed within 8 h. In contrast, down-regulation of PKC-epsilon to 10-20% of that found in control cells requires a 24 h treatment with PMA.	Tetradecanoylphorbol Acetate	15-18	protein kinase C, alpha	Rattus norvegicus	43-52
16319225-5	2005	In primary CD8(+) T cells, which express only TR2 and TR4 and are resistant to TRAIL-induced apoptosis, stimulation with phorbol myristate acetate abrogated the ligand-independent interaction between TR2 and TR4 and enhanced their sensitivity to TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	121-146	taste 1 receptor member 2	Homo sapiens	200-203
16319225-5	2005	In primary CD8(+) T cells, which express only TR2 and TR4 and are resistant to TRAIL-induced apoptosis, stimulation with phorbol myristate acetate abrogated the ligand-independent interaction between TR2 and TR4 and enhanced their sensitivity to TRAIL-induced apoptosis.	Tetradecanoylphorbol Acetate	121-146	TNF receptor superfamily member 10d	Homo sapiens	208-211
1659379-6	1991	On exposure to PMA a complete depletion of PKC-alpha is observed within 8 h. In contrast, down-regulation of PKC-epsilon to 10-20% of that found in control cells requires a 24 h treatment with PMA.	Tetradecanoylphorbol Acetate	193-196	protein kinase C, alpha	Rattus norvegicus	43-52
16251219-7	2005	On the other hand, enhanced basal expression of IL-15Ralpha was detected in leucocytes from SLE patients, with defective induction upon stimulation with phytohaemagglutinin or phorbol myristate acetate/ionomycin.	Tetradecanoylphorbol Acetate	176-201	interleukin 15 receptor subunit alpha	Homo sapiens	48-59
1928327-5	1991	Calmidazolium partially inhibited the PMA-induced translocation of PKC.	Tetradecanoylphorbol Acetate	38-41	protein kinase C, gamma	Rattus norvegicus	67-70
16356124-2	2005	In the present study, we investigated the possible inhibitory effects of curcumin on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in MCF10A human breast epithelial (MCF10A) cells and the underlying mechanisms.	Tetradecanoylphorbol Acetate	149-185	matrix metallopeptidase 9	Homo sapiens	113-118
16356124-2	2005	In the present study, we investigated the possible inhibitory effects of curcumin on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in MCF10A human breast epithelial (MCF10A) cells and the underlying mechanisms.	Tetradecanoylphorbol Acetate	187-190	matrix metallopeptidase 9	Homo sapiens	113-118
1928327-6	1991	These results suggest that 1) the calmodulin antagonists inhibit the development of PMA-induced contraction, at least in part, through inhibition of PKC translocation; 2) the mechanisms of phorbol ester- and agonist-induced translocation of PKC are distinct; 3) the potencies and inhibitory mechanisms of these agents depend on whether the agents are added before or during the contraction; and 4) the selectivity of these agents, as evaluated in enzyme preparations, may not be consistent with their cellular actions.	Tetradecanoylphorbol Acetate	84-87	protein kinase C, gamma	Rattus norvegicus	149-152
16356124-7	2005	Treatment of MCF10A cells with U0126, which is a pharmacological inhibitor of ERK1/2, reduced TPA-induced up-regulation of COX-2 and MMP-9.	Tetradecanoylphorbol Acetate	94-97	matrix metallopeptidase 9	Homo sapiens	133-138
16356124-8	2005	Taken together, these findings suggest that curcumin inhibits the TPA-induced up-regulation of COX-2 and MMP-9 by suppressing ERK1/2 phosphorylation and NF-kappaB trans-activation in human breast epithelial cells, which may contribute to its chemopreventive potential.	Tetradecanoylphorbol Acetate	66-69	matrix metallopeptidase 9	Homo sapiens	105-110
1928327-6	1991	These results suggest that 1) the calmodulin antagonists inhibit the development of PMA-induced contraction, at least in part, through inhibition of PKC translocation; 2) the mechanisms of phorbol ester- and agonist-induced translocation of PKC are distinct; 3) the potencies and inhibitory mechanisms of these agents depend on whether the agents are added before or during the contraction; and 4) the selectivity of these agents, as evaluated in enzyme preparations, may not be consistent with their cellular actions.	Tetradecanoylphorbol Acetate	84-87	protein kinase C, gamma	Rattus norvegicus	241-244
1930148-11	1991	Furthermore, phorbol 12-myristate 13-acetate blocked the HDL3-induced rise in [Ca2+]i.	Tetradecanoylphorbol Acetate	13-44	carbonic anhydrase 2	Homo sapiens	79-82
15927450-10	2005	In addition, RO 31-8220, a potent PKC inhibitor that blocks PMA-induced PKD3 activation in vivo, significantly attenuates the plasma membrane translocation of wild-type PKD3 at different doses of PMA.	Tetradecanoylphorbol Acetate	60-63	PKD3	Homo sapiens	72-76
15927450-10	2005	In addition, RO 31-8220, a potent PKC inhibitor that blocks PMA-induced PKD3 activation in vivo, significantly attenuates the plasma membrane translocation of wild-type PKD3 at different doses of PMA.	Tetradecanoylphorbol Acetate	60-63	PKD3	Homo sapiens	169-173
1838021-5	1991	In neonatal cultured rat atrial myocytes, protein kinase C activation by 12-O-tetradecanoylphorbol 13-acetate stimulated ANF secretion, whereas the release was unresponsive to changes in intracellular Ca2+.	Tetradecanoylphorbol Acetate	73-109	natriuretic peptide A	Rattus norvegicus	121-124
15927450-10	2005	In addition, RO 31-8220, a potent PKC inhibitor that blocks PMA-induced PKD3 activation in vivo, significantly attenuates the plasma membrane translocation of wild-type PKD3 at different doses of PMA.	Tetradecanoylphorbol Acetate	196-199	PKD3	Homo sapiens	169-173
15994198-6	2005	In the enhancer, an Oct-1 binding site, a Pbx/Prep binding site, Msx/Dlx binding sites, and a previously unidentified protein-binding element at -1793, all contribute to TPA suppression.	Tetradecanoylphorbol Acetate	170-173	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	20-25
15994198-7	2005	TPA treatment leads to decreased binding of Oct-1 and Pbx1a/Prep to their sites.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	44-49
1894734-6	1991	Furthermore, protein kinase C activators, such as 12-O-tetradecanoylphorbol 13-acetate (TPA) or 1-oleoyl-2-acetyl glycerol (OAG), consistently potentiate BV-2 cell-mediated anti-Candida activity, the phenomena being dose-dependent.	Tetradecanoylphorbol Acetate	50-86	mitogen-activated protein kinase kinase kinase 14	Mus musculus	13-27
16109712-2	2005	To gain insight into these mechanisms, human DAT was purified in large amounts using a two-step affinity chromatography procedure from untreated HeLa cells or cells treated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	178-209	solute carrier family 6 member 3	Homo sapiens	45-48
1894734-6	1991	Furthermore, protein kinase C activators, such as 12-O-tetradecanoylphorbol 13-acetate (TPA) or 1-oleoyl-2-acetyl glycerol (OAG), consistently potentiate BV-2 cell-mediated anti-Candida activity, the phenomena being dose-dependent.	Tetradecanoylphorbol Acetate	88-91	mitogen-activated protein kinase kinase kinase 14	Mus musculus	13-27
16109712-2	2005	To gain insight into these mechanisms, human DAT was purified in large amounts using a two-step affinity chromatography procedure from untreated HeLa cells or cells treated with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	211-214	solute carrier family 6 member 3	Homo sapiens	45-48
16109712-3	2005	Mass spectrometric analysis of purified DAT complexes revealed the presence of several proteins, among which ubiquitin was particularly abundant in the PMA-treated sample.	Tetradecanoylphorbol Acetate	152-155	solute carrier family 6 member 3	Homo sapiens	40-43
1917935-1	1991	Phorbol esters (TPA) and concanavalin A (ConA) are known to induce granulocyte-macrophage colony-stimulating factor (GM-CSF) production in murine thymoma EL-4 cells by mRNA stabilization.	Tetradecanoylphorbol Acetate	16-19	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	67-115
16109712-4	2005	Western blotting of highly purified DAT protein confirmed constitutive ubiquitylation of DAT and a dramatic increase in DAT ubiquitylation in cells treated with PMA.	Tetradecanoylphorbol Acetate	161-164	solute carrier family 6 member 3	Homo sapiens	36-39
1917935-1	1991	Phorbol esters (TPA) and concanavalin A (ConA) are known to induce granulocyte-macrophage colony-stimulating factor (GM-CSF) production in murine thymoma EL-4 cells by mRNA stabilization.	Tetradecanoylphorbol Acetate	16-19	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	117-123
16230392-5	2005	Unlike EP3 knockout mice, the EP2 knockout mice produced significantly fewer tumors and reduced tumor incidence compared with wild type (WT) mice in a 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) two-stage carcinogenesis protocol.	Tetradecanoylphorbol Acetate	189-225	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	30-33
1917935-2	1991	The role of the 3"-untranslated region (3"-UTR) in GM-CSF mRNA stabilization induced by TPA and ConA in EL-4 cells was examined by transfection studies using chloramphenicol acetyltransferase (CAT) constructions.	Tetradecanoylphorbol Acetate	88-91	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	51-57
16230392-5	2005	Unlike EP3 knockout mice, the EP2 knockout mice produced significantly fewer tumors and reduced tumor incidence compared with wild type (WT) mice in a 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) two-stage carcinogenesis protocol.	Tetradecanoylphorbol Acetate	227-230	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	30-33
16230392-7	2005	In addition, the epidermis of EP2 knockout mice 48 hours after topical TPA treatment was significantly thinner compared with that of WT mice.	Tetradecanoylphorbol Acetate	71-74	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	30-33
1873807-0	1991	Tumor promoter 12-O-tetradecanoylphorbol-13-acetate and sn-1,2-dioctanoylglycerol increase the phosphorylation of protein kinase C in cells.	Tetradecanoylphorbol Acetate	15-51	protein kinase C, gamma	Rattus norvegicus	114-130
16230392-8	2005	The inflammatory response to TPA was reduced in EP2 knockout mice, based on a reduced number of macrophages in the dermis and a reduced level of interleukin-1alpha mRNA expression, compared with WT mice.	Tetradecanoylphorbol Acetate	29-32	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	48-51
18282766-5	2008	Respiratory burst was stimulated by trout atrial natriuretic peptide, trout C-type natriuretic peptide-1 and 8-bromo-cGMP in a dose dependant manner with the highest activity as a result of stimulation with trout C-type natriuretic peptide-1 in excess of that achieved by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	272-297	C-type natriuretic peptide 1	Oncorhynchus mykiss	76-104
18282766-5	2008	Respiratory burst was stimulated by trout atrial natriuretic peptide, trout C-type natriuretic peptide-1 and 8-bromo-cGMP in a dose dependant manner with the highest activity as a result of stimulation with trout C-type natriuretic peptide-1 in excess of that achieved by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	272-297	C-type natriuretic peptide 1	Oncorhynchus mykiss	213-241
18282766-5	2008	Respiratory burst was stimulated by trout atrial natriuretic peptide, trout C-type natriuretic peptide-1 and 8-bromo-cGMP in a dose dependant manner with the highest activity as a result of stimulation with trout C-type natriuretic peptide-1 in excess of that achieved by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	299-302	C-type natriuretic peptide 1	Oncorhynchus mykiss	76-104
18282766-5	2008	Respiratory burst was stimulated by trout atrial natriuretic peptide, trout C-type natriuretic peptide-1 and 8-bromo-cGMP in a dose dependant manner with the highest activity as a result of stimulation with trout C-type natriuretic peptide-1 in excess of that achieved by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	299-302	C-type natriuretic peptide 1	Oncorhynchus mykiss	213-241
16405934-2	2005	Following stimulation with phorbol 12-myristate 13-acetate and ionomycin, anti-CD3/CD28, antigen-specific peptide, or allogeneic cells, both CD4 and CD8 T cells expressed the transgene within 24h in a manner that was consistent with cellular activation markers.	Tetradecanoylphorbol Acetate	27-58	CD4 antigen	Mus musculus	141-144
1873807-6	1991	The autophosphorylation of PKC was stimulated by treatment of C3H 10T1/2 cells with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate or sn-1,2-dioctanoylglycerol.	Tetradecanoylphorbol Acetate	103-139	protein kinase C, gamma	Rattus norvegicus	27-30
1873807-7	1991	Exposure of cells to 100 nM 12-O-tetradecanoylphorbol-13-acetate for 15 min increased the phosphorylation of PKC by 5-fold in the particulate fraction, while treatment with 100 microM dioctanoylglycerol enhanced phosphorylation of PKC only by 2-fold.	Tetradecanoylphorbol Acetate	28-64	protein kinase C, gamma	Rattus norvegicus	109-112
1873807-7	1991	Exposure of cells to 100 nM 12-O-tetradecanoylphorbol-13-acetate for 15 min increased the phosphorylation of PKC by 5-fold in the particulate fraction, while treatment with 100 microM dioctanoylglycerol enhanced phosphorylation of PKC only by 2-fold.	Tetradecanoylphorbol Acetate	28-64	protein kinase C, gamma	Rattus norvegicus	231-234
1682409-3	1991	Expression of CD54 is increased by cytokines (gamma-interferon, tumour necrosis factor, interleukin-1) and by an activator of C-kinase, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	136-167	intercellular adhesion molecule 1	Rattus norvegicus	14-18
16175052-5	2005	alpha-Santalol treatment (1.25% and 2.5%) resulted in a significant decrease in the TPA-induced ODC activity and incorporation of [3H]thymidine in DNA in the epidermis of CD-1 mice.	Tetradecanoylphorbol Acetate	84-87	ornithine decarboxylase, structural 1	Mus musculus	96-99
16272134-6	2005	Mutations of this site diminished the synergistic effect on the promoter activity induced by PMA and oleic acid, suggesting a possible interaction between this site and the downstream PPARdelta site.	Tetradecanoylphorbol Acetate	93-96	peroxisome proliferator activated receptor delta	Homo sapiens	184-193
18372238-3	2008	In transient co-transfection assays, phorbol myristate acetate (PMA) suppressed LXR-dependent transactivation of LXR-responsive reporter genes or the natural promoter of the human ATP-binding cassette (ABC), ABCA1 gene.	Tetradecanoylphorbol Acetate	37-62	ATP binding cassette subfamily A member 1	Homo sapiens	208-213
18372238-3	2008	In transient co-transfection assays, phorbol myristate acetate (PMA) suppressed LXR-dependent transactivation of LXR-responsive reporter genes or the natural promoter of the human ATP-binding cassette (ABC), ABCA1 gene.	Tetradecanoylphorbol Acetate	64-67	ATP binding cassette subfamily A member 1	Homo sapiens	208-213
16111532-4	2005	TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64.	Tetradecanoylphorbol Acetate	0-3	CD9 molecule	Homo sapiens	77-80
1861147-6	1991	Short (10 min) pretreatment with tetradecanoylphorbol acetate (TPA) almost completely eliminated the bradykinin-stimulated formation of inositol phosphates, but failed to affect bradykinin stimulation of label in PA, suggesting that PA production in response to bradykinin is not downstream of phospholipase C activation.	Tetradecanoylphorbol Acetate	33-61	kininogen 1	Bos taurus	101-111
16111532-4	2005	TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64.	Tetradecanoylphorbol Acetate	0-3	integrin subunit alpha M	Homo sapiens	82-87
16111532-4	2005	TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64.	Tetradecanoylphorbol Acetate	0-3	intercellular adhesion molecule 1	Homo sapiens	89-93
17996892-9	2008	Conversely, the PKC activator Phorbol-12-myristate-13-acetate (0.5 microM, n=7) mimicked the effect of NPY and significantly reduced (3)H-acetylcholine release during field stimulation.	Tetradecanoylphorbol Acetate	30-61	pro-neuropeptide Y	Cavia porcellus	103-106
18070609-5	2008	Functional studies with Gal4-p65 constructs revealed that serine 276 is crucial to confer LPS-dependent repression of TPA-mediated induction of p65 transactivation.	Tetradecanoylphorbol Acetate	118-121	galectin 4	Homo sapiens	24-28
1861147-6	1991	Short (10 min) pretreatment with tetradecanoylphorbol acetate (TPA) almost completely eliminated the bradykinin-stimulated formation of inositol phosphates, but failed to affect bradykinin stimulation of label in PA, suggesting that PA production in response to bradykinin is not downstream of phospholipase C activation.	Tetradecanoylphorbol Acetate	63-66	kininogen 1	Bos taurus	101-111
18070596-4	2008	Further mechanistic studies revealed that irisolidone inhibits the binding of NF-kappaB and AP-1 to the MMP-9 promoter and suppresses the PMA-induced phosphorylation of ERK and JNK, which are upstream signaling molecules in MMP-9 expression.	Tetradecanoylphorbol Acetate	138-141	matrix metallopeptidase 9	Homo sapiens	224-229
1652760-5	1991	Treatment of a T-cell leukemia line (Jurkat) with either phytohemagglutinin or anti-CD3 antibodies induced phosphorylation of tyrosine residues in CD45; treatment with phorbol 12-myristate 13-acetate did not.	Tetradecanoylphorbol Acetate	168-199	protein tyrosine phosphatase receptor type C	Homo sapiens	147-151
16277846-6	2005	In ATRA and TPA group, the change of HSP70 had positive correlation with JWA, and negative correlation with Bcl-2.	Tetradecanoylphorbol Acetate	12-15	heat shock protein family A (Hsp70) member 4	Homo sapiens	37-42
16277846-6	2005	In ATRA and TPA group, the change of HSP70 had positive correlation with JWA, and negative correlation with Bcl-2.	Tetradecanoylphorbol Acetate	12-15	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	73-76
16277846-10	2005	It is concluded that JWA may play double important roles in regulating ATRA and TPA-induced differentiation and apoptosis in leukemic cells.	Tetradecanoylphorbol Acetate	80-83	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	21-24
18045946-3	2008	Cytokine flow cytometry was utilized to assess production of Th1 cytokines tumor necrosis factor alpha and gamma interferon following ex vivo stimulation with either phorbol myristate acetate/ionomycin or the Vdelta2 gammadelta T-cell receptor agonist isopentenyl pyrophosphate.	Tetradecanoylphorbol Acetate	166-191	negative elongation factor complex member C/D	Homo sapiens	61-64
1652474-4	1991	PMA stimulated phosphorylation of a single major IGF-I receptor phosphoserine peptide which was phosphorylated to a lesser extent after IGF-I.	Tetradecanoylphorbol Acetate	0-3	insulin like growth factor 1 receptor	Homo sapiens	49-63
16045733-5	2005	As a result of it the amount of interferon-gamma producing CD7(+) T-cells and the concentration of interferon-gamma in cultural supernatants were maximal in the cell cultures incubated with anti-CD3, interleukin-7 and dexamethasone during the first 68 h and subsequently restimulated with phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	289-320	CD7 molecule	Homo sapiens	59-62
1909114-1	1991	In JB6 epidermal cells, induction of fos proto-oncogene expression by phorbol 12-myristate 13-acetate can be inhibited by the protein kinase C (PKC) inhibitor H7 [1-5(isoquinolinesulphonyl)-2-methylpiperazine].	Tetradecanoylphorbol Acetate	70-101	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-40
16085055-7	2005	In this study, we demonstrate that tumor cells activated to bind HA by cytokines rapidly release CD44 upon treatment with phorbol ester (PMA).	Tetradecanoylphorbol Acetate	137-140	CD44 molecule (Indian blood group)	Homo sapiens	97-101
1782669-7	1991	Induction of c-fos and c-myc occurred at both temperatures after the stimulation with FBS, TPA or A23187.	Tetradecanoylphorbol Acetate	91-94	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-18
16061178-1	2005	Activation of the Jun-N-terminal kinase (JNK) signaling cascade by phorbol esters (TPA) or protein kinase C (PKC) is well documented, although the underlying mechanism is not known.	Tetradecanoylphorbol Acetate	83-86	mitogen-activated protein kinase 8	Mus musculus	18-39
16061178-1	2005	Activation of the Jun-N-terminal kinase (JNK) signaling cascade by phorbol esters (TPA) or protein kinase C (PKC) is well documented, although the underlying mechanism is not known.	Tetradecanoylphorbol Acetate	83-86	mitogen-activated protein kinase 8	Mus musculus	41-44
16061178-4	2005	Ser129 phosphorylation augments JNK phosphorylation by MKK4 and/or MKK7 and is required for JNK activation by TPA, TNFalpha, UV irradiation, and PKC, but not by anisomycin or MEKK1.	Tetradecanoylphorbol Acetate	110-113	mitogen-activated protein kinase 8	Mus musculus	92-95
1839520-2	1991	It exhibited in vitro inhibitory effects on the diolein and TPA (12-O-tetradecanoylphorbol-13-acetate) induced activation of Protein Kinase C (PKC) from rat brain and also showed inhibitory effects on the calcium/phospholipid-independent phosphorylation of protamine by PKC.	Tetradecanoylphorbol Acetate	60-63	protein kinase C, gamma	Rattus norvegicus	125-141
1839520-2	1991	It exhibited in vitro inhibitory effects on the diolein and TPA (12-O-tetradecanoylphorbol-13-acetate) induced activation of Protein Kinase C (PKC) from rat brain and also showed inhibitory effects on the calcium/phospholipid-independent phosphorylation of protamine by PKC.	Tetradecanoylphorbol Acetate	60-63	protein kinase C, gamma	Rattus norvegicus	143-146
16046711-7	2005	The insulin secretion induced by phorbol 12-myristate 13-acetate (a stimulator of PKC) was higher in islets of LPN and LPP rats than in the respective controls, especially at 8.3 mmol glucose/L.	Tetradecanoylphorbol Acetate	33-64	protein kinase C, alpha	Rattus norvegicus	82-85
1839520-2	1991	It exhibited in vitro inhibitory effects on the diolein and TPA (12-O-tetradecanoylphorbol-13-acetate) induced activation of Protein Kinase C (PKC) from rat brain and also showed inhibitory effects on the calcium/phospholipid-independent phosphorylation of protamine by PKC.	Tetradecanoylphorbol Acetate	60-63	protein kinase C, gamma	Rattus norvegicus	270-273
1839520-2	1991	It exhibited in vitro inhibitory effects on the diolein and TPA (12-O-tetradecanoylphorbol-13-acetate) induced activation of Protein Kinase C (PKC) from rat brain and also showed inhibitory effects on the calcium/phospholipid-independent phosphorylation of protamine by PKC.	Tetradecanoylphorbol Acetate	65-101	protein kinase C, gamma	Rattus norvegicus	125-141
1839520-2	1991	It exhibited in vitro inhibitory effects on the diolein and TPA (12-O-tetradecanoylphorbol-13-acetate) induced activation of Protein Kinase C (PKC) from rat brain and also showed inhibitory effects on the calcium/phospholipid-independent phosphorylation of protamine by PKC.	Tetradecanoylphorbol Acetate	65-101	protein kinase C, gamma	Rattus norvegicus	143-146
1839520-2	1991	It exhibited in vitro inhibitory effects on the diolein and TPA (12-O-tetradecanoylphorbol-13-acetate) induced activation of Protein Kinase C (PKC) from rat brain and also showed inhibitory effects on the calcium/phospholipid-independent phosphorylation of protamine by PKC.	Tetradecanoylphorbol Acetate	65-101	protein kinase C, gamma	Rattus norvegicus	270-273
15979384-6	2005	Interestingly, phorbol myristate acetate together with IKKalpha gene transfection strongly inhibited the expression of involucrin in SCC cells and induced the phosphorylation of serine residue in IKKalpha, suggesting that protein kinase C is involved in the effect of IKKalpha on the differentiation of SCC cells.	Tetradecanoylphorbol Acetate	15-40	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	196-204
1649821-5	1991	As indicated by measurement of oxygen consumption, the purified cytochrome catalytically reduced oxygen at a rate equal to approximately 30% of the activity of the phorbol myristate acetate-activated cells on the basis of cytochrome b558 content.	Tetradecanoylphorbol Acetate	164-189	cytochrome b, mitochondrial	Rattus norvegicus	222-234
15979384-6	2005	Interestingly, phorbol myristate acetate together with IKKalpha gene transfection strongly inhibited the expression of involucrin in SCC cells and induced the phosphorylation of serine residue in IKKalpha, suggesting that protein kinase C is involved in the effect of IKKalpha on the differentiation of SCC cells.	Tetradecanoylphorbol Acetate	15-40	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	196-204
1859360-4	1991	IL 1 and phorbol 12-myristate 13-acetate (PMA) also induced an increase in the constitutive hsp70 mRNA species, but without affecting the expression of the inducible hsp70 gene.	Tetradecanoylphorbol Acetate	42-45	heat shock protein family A (Hsp70) member 4	Homo sapiens	166-171
21162189-8	2005	Pretreatment of PKC inhibitor chelerythrine chloride blocked the changes induced by PMA.	Tetradecanoylphorbol Acetate	84-87	protein kinase C, gamma	Rattus norvegicus	16-19
1850009-1	1991	The promoter for the 2.8-kb RNA of Epstein-Barr virus encoding BZLF1 and BRLF1 was identified and shown to be activated by both BZLF1 and BRLF1 but not by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	155-191	BRLF1	Human gammaherpesvirus 4	73-78
16005455-5	2005	PMA treatment produced a concentration-dependent increase in cell injury and PKC activity.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	77-80
1675782-3	1991	We report here that incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates the phosphorylation of the normal neu protein (p185) and the oncogenic neu protein (p185*).	Tetradecanoylphorbol Acetate	45-81	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	146-150
1675782-3	1991	We report here that incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates the phosphorylation of the normal neu protein (p185) and the oncogenic neu protein (p185*).	Tetradecanoylphorbol Acetate	45-81	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	183-187
15920718-4	2005	Mrp/plf-mRNA was not detected in Northern blot hybridizations, but large increases in mRNAs for ornithine decarboxylase gene and mRNA (odc), v-jun oncogene-related transcription factor gene and mRNA (junB), egr1 (early growth response protein gene and mRNA) were measured relative to beta 2 microglobulin gene and mRNA (b2m) mRNA in response to TPA.	Tetradecanoylphorbol Acetate	345-348	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	0-3
1675782-3	1991	We report here that incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates the phosphorylation of the normal neu protein (p185) and the oncogenic neu protein (p185*).	Tetradecanoylphorbol Acetate	83-86	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	146-150
1675782-3	1991	We report here that incubation of cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates the phosphorylation of the normal neu protein (p185) and the oncogenic neu protein (p185*).	Tetradecanoylphorbol Acetate	83-86	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	183-187
16342423-8	2005	In H9c2 cells, coincubation with PMA lead to an increase in the rate of the IGF1 receptor activation, and this may further implicate a role for PKC in regulating the IGF1R.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, alpha	Rattus norvegicus	144-147
1675782-5	1991	Phosphate labeling experiments showed that TPA causes a reduction of basal phosphotyrosine in p185 but not p185*.	Tetradecanoylphorbol Acetate	43-46	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	94-98
1675782-7	1991	TPA also inhibited tyrosine phosphorylation of p185* in an in vitro immune complex kinase assay.	Tetradecanoylphorbol Acetate	0-3	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	47-51
1675782-8	1991	These data suggest that protein kinase C, the receptor for TPA, regulates p185 function through serine or threonine phosphorylation.	Tetradecanoylphorbol Acetate	59-62	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	74-78
15833746-3	2005	12-O-Tetradecanoylphorbol-13-acetate treatment or expression of an alpha-secretase enzyme, ADAM10, resulted in ectodomain cleavage of beta2 in Chinese hamster ovary cells.	Tetradecanoylphorbol Acetate	0-36	hemoglobin, beta adult minor chain	Mus musculus	134-139
15824103-3	2005	Here we show that ectopic expression of Nox3 in various types of cells leads to phorbol 12-myristate 13-acetate-independent constitutive production of a substantial amount of superoxide under the conditions where gp91(phox) and Nox1 fail to generate superoxide, i.e. in the absence of the oxidase organizers and activators.	Tetradecanoylphorbol Acetate	80-111	NADPH oxidase 3	Mus musculus	40-44
1902229-10	1991	Experiments using phorbol ester (phorbol 12-myristate 13-acetate) in combination with the Ca2+ ionophore ionomycin confirm that activation of protein kinase C induces c-fos and c-jun expression and that a concomitant increase in cytosolic [Ca2+] potentiates the induction of c-fos while repressing that of c-jun.	Tetradecanoylphorbol Acetate	33-64	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-172
1902229-10	1991	Experiments using phorbol ester (phorbol 12-myristate 13-acetate) in combination with the Ca2+ ionophore ionomycin confirm that activation of protein kinase C induces c-fos and c-jun expression and that a concomitant increase in cytosolic [Ca2+] potentiates the induction of c-fos while repressing that of c-jun.	Tetradecanoylphorbol Acetate	33-64	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	177-182
15922088-7	2005	The VEGF synthesis stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), a direct activator of PKC, was suppressed by tiludronate.	Tetradecanoylphorbol Acetate	33-69	vascular endothelial growth factor A	Mus musculus	4-8
1902229-10	1991	Experiments using phorbol ester (phorbol 12-myristate 13-acetate) in combination with the Ca2+ ionophore ionomycin confirm that activation of protein kinase C induces c-fos and c-jun expression and that a concomitant increase in cytosolic [Ca2+] potentiates the induction of c-fos while repressing that of c-jun.	Tetradecanoylphorbol Acetate	33-64	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	275-280
15922088-7	2005	The VEGF synthesis stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), a direct activator of PKC, was suppressed by tiludronate.	Tetradecanoylphorbol Acetate	71-74	vascular endothelial growth factor A	Mus musculus	4-8
1902229-10	1991	Experiments using phorbol ester (phorbol 12-myristate 13-acetate) in combination with the Ca2+ ionophore ionomycin confirm that activation of protein kinase C induces c-fos and c-jun expression and that a concomitant increase in cytosolic [Ca2+] potentiates the induction of c-fos while repressing that of c-jun.	Tetradecanoylphorbol Acetate	33-64	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	306-311
15922088-8	2005	The TPA-induced phosphorylations of Raf-1, MEK1/2 and p44/p42 MAP kinase were inhibited by tiludronate.	Tetradecanoylphorbol Acetate	4-7	v-raf-leukemia viral oncogene 1	Mus musculus	36-41
1903305-4	1991	Although not effective as an agonist, phorbol myristate acetate potentiated A23187- and bradykinin-stimulated synthesis of 1-radyl-2-[3H]acetyl-GPC.	Tetradecanoylphorbol Acetate	38-63	kininogen 1	Bos taurus	88-98
15784625-8	2005	Nectin-4 shedding is constitutive, strongly enhanced by 12-O-tetradecanoylphorbol-13-acetate activation, and reduced tumor necrosis factor-alpha protease inhibitor TAPI-1 or by the tissue inhibitor of metalloproteinase-3 (TIMP-3).	Tetradecanoylphorbol Acetate	56-92	nectin cell adhesion molecule 4	Homo sapiens	0-8
1903305-4	1991	Although not effective as an agonist, phorbol myristate acetate potentiated A23187- and bradykinin-stimulated synthesis of 1-radyl-2-[3H]acetyl-GPC.	Tetradecanoylphorbol Acetate	38-63	glycophorin C	Bos taurus	144-147
1849366-7	1991	Activation of protein kinase C by phorbol 12-myristate-13-acetate (PMA) decreases ANP-stimulated IP3 production.	Tetradecanoylphorbol Acetate	34-65	natriuretic peptide A	Rattus norvegicus	82-85
15878350-7	2005	In HEK-293 cells transfected with rat EBP50 cDNA, a treatment with 12 myristate 13-acetate (PMA) induced a translocation of PKCalpha and beta isoforms to the membrane and increased 32P incorporation into EBP50.	Tetradecanoylphorbol Acetate	92-95	protein kinase C, alpha	Rattus norvegicus	124-132
15757899-4	2005	Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.	Tetradecanoylphorbol Acetate	63-66	growth differentiation factor 15	Homo sapiens	234-239
1849366-7	1991	Activation of protein kinase C by phorbol 12-myristate-13-acetate (PMA) decreases ANP-stimulated IP3 production.	Tetradecanoylphorbol Acetate	67-70	natriuretic peptide A	Rattus norvegicus	82-85
15757899-7	2005	Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival.	Tetradecanoylphorbol Acetate	14-17	growth differentiation factor 15	Homo sapiens	26-31
2018470-4	1991	The PMA-induced stimulation of both transport and transporter translocation was substantially less than that induced by insulin in this cell line; the PMA-induced increase in plasma-membrane GLUT 1 and GLUT 4 transporter isoforms was only about 40% and 10% respectively of that induced by insulin.	Tetradecanoylphorbol Acetate	151-154	solute carrier family 2 member 1	Homo sapiens	191-197
15757899-7	2005	Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival.	Tetradecanoylphorbol Acetate	14-17	growth differentiation factor 15	Homo sapiens	46-51
15757899-7	2005	Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival.	Tetradecanoylphorbol Acetate	14-17	growth differentiation factor 15	Homo sapiens	46-51
15757899-7	2005	Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival.	Tetradecanoylphorbol Acetate	82-85	growth differentiation factor 15	Homo sapiens	26-31
15757899-7	2005	Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival.	Tetradecanoylphorbol Acetate	82-85	growth differentiation factor 15	Homo sapiens	46-51
15757899-7	2005	Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival.	Tetradecanoylphorbol Acetate	82-85	growth differentiation factor 15	Homo sapiens	46-51
15757899-8	2005	These results demonstrate that NAG-1 expression is up-regulated by TPA in LNCaP cells through a PKC-dependent pathway involving the activation of NF-kappa B.	Tetradecanoylphorbol Acetate	67-70	growth differentiation factor 15	Homo sapiens	31-36
1848566-8	1991	In cell culture conditions both ACTH and a protein kinase C regulator 12-O-tetradecanoyl phorbol-13-acetate induced 3 beta HSD gene expression.	Tetradecanoylphorbol Acetate	70-107	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	116-126
18178624-3	2008	When exposed to a combination of DMBA/TPA, mice lacking MyD88 formed fewer skin papillomas than genetically matched WT controls treated in a similar manner.	Tetradecanoylphorbol Acetate	38-41	myeloid differentiation primary response gene 88	Mus musculus	56-61
1848116-6	1991	NGF enhanced the superoxide production induced by phorbol 12-myristate 13-acetate (PMA), which acts at postreceptor sites, and that induced by opsonized zymosan, a receptor-mediated ligand.	Tetradecanoylphorbol Acetate	50-81	nerve growth factor	Mus musculus	0-3
18024477-0	2008	Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	24-27	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	176-180
18024477-4	2008	The results showed that the LAB suppressed PMA-induced MMP-9 activity in a dose-dependent transcriptional level.	Tetradecanoylphorbol Acetate	43-46	matrix metallopeptidase 9	Homo sapiens	55-60
18024477-7	2008	Moreover, LAB also strongly inhibited PMA-stimulated nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) DNA-binding activities of HepG(2) cells in dose-dependent manners.	Tetradecanoylphorbol Acetate	38-41	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	92-111
18024477-7	2008	Moreover, LAB also strongly inhibited PMA-stimulated nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) DNA-binding activities of HepG(2) cells in dose-dependent manners.	Tetradecanoylphorbol Acetate	38-41	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-117
18234971-0	2008	A JNK1/AP-1-dependent, COX-2 induction is implicated in 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation through regulating cell cycle progression.	Tetradecanoylphorbol Acetate	56-92	mitogen-activated protein kinase 8	Mus musculus	2-6
15820131-3	2005	We have extended our previous studies on a porcine spleen galectin-1 in relation to its functional roles such as polymorphonuclear neutrophils (PMNs) stimulation compared to well known PMN activators e.g. N-formyl-L-methionyl-L leucyl-L-phenylalanine (fMLP) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	262-293	galectin 1	Sus scrofa	58-68
15820131-3	2005	We have extended our previous studies on a porcine spleen galectin-1 in relation to its functional roles such as polymorphonuclear neutrophils (PMNs) stimulation compared to well known PMN activators e.g. N-formyl-L-methionyl-L leucyl-L-phenylalanine (fMLP) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	295-298	galectin 1	Sus scrofa	58-68
15733533-4	2005	ST2 mRNA was produced from the distal promoter in EL-4 cells stimulated with both phorbol 12-myristate 13-acetate (PMA) and dibutyryl cAMP (Bt2cAMP).	Tetradecanoylphorbol Acetate	82-113	interleukin 1 receptor-like 1	Mus musculus	0-3
18063832-6	2008	We aimed to determine the change in plasma F2IP levels over time and relationship with plasma MMP-9 in tPA-treated and tPA-untreated stroke patients.	Tetradecanoylphorbol Acetate	103-106	matrix metallopeptidase 9	Homo sapiens	94-99
1848116-6	1991	NGF enhanced the superoxide production induced by phorbol 12-myristate 13-acetate (PMA), which acts at postreceptor sites, and that induced by opsonized zymosan, a receptor-mediated ligand.	Tetradecanoylphorbol Acetate	83-86	nerve growth factor	Mus musculus	0-3
1901251-9	1991	The stimulation of chemiluminescence by TPA was inhibited by the addition of phospholipase A2 (PLA2) inhibitor, 4-p-BPB; this metabolic inhibitor did not affect the decrease of chemiluminescence production induced by DEN.	Tetradecanoylphorbol Acetate	40-43	phospholipase A2, group IB, pancreas	Mus musculus	77-93
17942404-3	2007	In the present study we present new evidence that a disintegrin and metalloproteinase-17 (ADAM17) is responsible for phorbol 12-myristate 13-acetate-induced release of TMEFF2-ECD using small interfering RNA to ablate ADAM17 expression or by inhibiting enzymatic activity.	Tetradecanoylphorbol Acetate	117-148	ADAM metallopeptidase domain 17	Homo sapiens	90-96
17942404-3	2007	In the present study we present new evidence that a disintegrin and metalloproteinase-17 (ADAM17) is responsible for phorbol 12-myristate 13-acetate-induced release of TMEFF2-ECD using small interfering RNA to ablate ADAM17 expression or by inhibiting enzymatic activity.	Tetradecanoylphorbol Acetate	117-148	ADAM metallopeptidase domain 17	Homo sapiens	217-223
15733533-4	2005	ST2 mRNA was produced from the distal promoter in EL-4 cells stimulated with both phorbol 12-myristate 13-acetate (PMA) and dibutyryl cAMP (Bt2cAMP).	Tetradecanoylphorbol Acetate	115-118	interleukin 1 receptor-like 1	Mus musculus	0-3
1901251-9	1991	The stimulation of chemiluminescence by TPA was inhibited by the addition of phospholipase A2 (PLA2) inhibitor, 4-p-BPB; this metabolic inhibitor did not affect the decrease of chemiluminescence production induced by DEN.	Tetradecanoylphorbol Acetate	40-43	phospholipase A2, group IB, pancreas	Mus musculus	95-99
1847859-7	1991	In fetal cultures TPA slightly increased P450scc, P450c11, and P450c21 mRNA levels, whereas it decreased P450c17 mRNA.	Tetradecanoylphorbol Acetate	18-21	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	50-57
15785969-6	2005	The expression of a large fraction of the 80 EBV genes was found to be activated after TPA treatment with a noticeable increase of 19 and 21 fold, respectively in BSLF1 and BBLF4.	Tetradecanoylphorbol Acetate	87-90	helicase-primase primase subunit	Human gammaherpesvirus 4	163-168
15828232-5	2005	In addition, the phorbol myristate acetate (PMA)-stimulated 22 kDa-subunit (p22phox) protein levels and 47 kDa-subunit (p47phox) protein levels in NADPH (superoxide generating enzyme nicotinamide adenine dinucleotide phosphate (reduced form)) oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	17-42	neutrophil cytosolic factor 1	Homo sapiens	120-127
17933457-12	2007	Lastly, the pharmacological AP-1 activator phorbol myristate acetate increased AP-1 binding, trans-activated the wild-type but not the AP-1 mutant NOS3 promoter and dose-dependently stimulated UAEC NOS3 and c-Jun protein expression.	Tetradecanoylphorbol Acetate	43-68	jun oncogene	Ovis aries	207-212
17942077-7	2007	We also observed that PKCalpha, beta1, beta2, gamma, delta, epsilon, and eta translocate to the plasma membrane within 10 min of the start of TPA treatment, while the cellular localizations of PKCzeta and iota were not affected by TPA.	Tetradecanoylphorbol Acetate	142-145	hemoglobin, beta adult minor chain	Mus musculus	39-76
17947801-6	2007	In addition, we have also shown that treatment of endothelial cells with phorbol 12-myristate 13-acetate resulted in the exportation of HDAC7 out of the nucleus through a protein kinase C/protein kinase D activation pathway and induced, similarly to HDAC7 silencing, an increase in PDGF-B expression, as well as a partial inhibition of endothelial cell migration.	Tetradecanoylphorbol Acetate	73-104	platelet derived growth factor subunit B	Homo sapiens	282-288
15828232-5	2005	In addition, the phorbol myristate acetate (PMA)-stimulated 22 kDa-subunit (p22phox) protein levels and 47 kDa-subunit (p47phox) protein levels in NADPH (superoxide generating enzyme nicotinamide adenine dinucleotide phosphate (reduced form)) oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators.	Tetradecanoylphorbol Acetate	44-47	neutrophil cytosolic factor 1	Homo sapiens	120-127
1899867-4	1991	Stimulation with arginine vasopressin, epidermal growth factor, or phorbol myristate acetate increased [3H]thymidine incorporation and mRNA levels of the immediate-early response genes c-fos and Egr-1.	Tetradecanoylphorbol Acetate	67-92	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	185-190
15777839-4	2005	Cholera toxin-induced activation of cAMP responsive element (CRE)-binding protein (CREB) was enhanced by pretreating cells with ATRA for 24 h. In contrast, HGF production induced by epidermal growth factor (EGF) or phorbol 12-myristate 13-acetate (PMA) was potently inhibited by ATRA.	Tetradecanoylphorbol Acetate	215-246	cAMP responsive element binding protein 1	Homo sapiens	83-87
17982670-6	2007	However, inhibition of PI-3K and JNK only caused decrease of TPA-induced B7-DC mRNA and B7-H3 mRNA, respectively.	Tetradecanoylphorbol Acetate	61-64	programmed cell death 1 ligand 2	Homo sapiens	73-78
17982670-8	2007	NF-kappaB inhibitors significantly attenuated the expression of B7-DC, -H1, -H2, and -H3 mRNA in response to TPA.	Tetradecanoylphorbol Acetate	109-112	programmed cell death 1 ligand 2	Homo sapiens	64-88
17982670-9	2007	These results suggest that TPA induces the expression of B7-DC, -H1, -H2, and -H3 mRNA in K562 cells via activation of PKC, ERK, p38 MAPK, and NF-kappaB.	Tetradecanoylphorbol Acetate	27-30	programmed cell death 1 ligand 2	Homo sapiens	57-81
17982670-10	2007	Distinctly, the expression of B7-DC mRNA and -H3 mRNA in response to TPA is also PI-3K- and JNK-dependent, respectively.	Tetradecanoylphorbol Acetate	69-72	programmed cell death 1 ligand 2	Homo sapiens	30-35
1826618-15	1991	Our present results indicate that the phorbol ester TPA increases the release of ANP from the hypertrophied, but not from normal rat myocardium.	Tetradecanoylphorbol Acetate	52-55	natriuretic peptide A	Rattus norvegicus	81-84
17895316-10	2007	Microarray data showed a 37-fold increase in c-fos after treatment with TPA.	Tetradecanoylphorbol Acetate	72-75	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-50
15777839-4	2005	Cholera toxin-induced activation of cAMP responsive element (CRE)-binding protein (CREB) was enhanced by pretreating cells with ATRA for 24 h. In contrast, HGF production induced by epidermal growth factor (EGF) or phorbol 12-myristate 13-acetate (PMA) was potently inhibited by ATRA.	Tetradecanoylphorbol Acetate	248-251	cAMP responsive element binding protein 1	Homo sapiens	83-87
15707581-3	2005	12-O-Tetradecanoylphorbol-13-acetate (followed for 2 h) caused dose- and time-dependent decreases in communication for five of seven connexins, the unresponsive being connexin45 and 57.	Tetradecanoylphorbol Acetate	0-36	gap junction protein, gamma 1	Mus musculus	167-177
1904375-1	1991	The product of the fos-related fosB gene shares many properties with c-Fos such as inducibility by growth factors, complex formation with members of the Jun family and cooperative binding with Jun to the TPA response element (TRE).	Tetradecanoylphorbol Acetate	204-207	FBJ osteosarcoma oncogene B	Mus musculus	31-35
17826795-12	2007	In experiment 2, GLN increased expression of CD11b and reactive oxygen intermediate with phorbol myristate acetate, compared with controls.	Tetradecanoylphorbol Acetate	89-114	integrin subunit alpha M	Homo sapiens	45-50
17583568-8	2007	The TPA resistance phenotype correlated with a reduced ability to induce ornithine decarboxylase, interleukin-1alpha, and tumor necrosis factor-alpha and a reduced proliferation response.	Tetradecanoylphorbol Acetate	4-7	ornithine decarboxylase, structural 1	Mus musculus	73-96
1899904-2	1991	The addition of exogenous arachidonic acid to cells pretreated with TPA resulted in increased PGE2 formation, compared with basal levels, indicating an elevation in prostaglandin H synthase (PHS) activity.	Tetradecanoylphorbol Acetate	68-71	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	165-189
17690255-4	2007	As early as 24 hours after sepsis, CD4(+) T cells proliferated poorly to T-cell receptor stimulation, despite normal responses to phorbol myristate acetate and ionomycin, and possessed decreased levels of CD3zeta.	Tetradecanoylphorbol Acetate	130-155	CD4 antigen	Mus musculus	35-38
17702895-5	2007	Importantly, silencing of the Rap1 guanine exchange factor CalDAG-GEFI inhibited SDF-1alpha- and phorbol 12-myristate 13-acetate (PMA)-induced adhesion to ICAM-1 while having no effect on adhesion to VCAM-1.	Tetradecanoylphorbol Acetate	97-128	intercellular adhesion molecule 1	Homo sapiens	155-161
15538571-13	2005	Quercetin promoted caspase-3 activity in a dose-dependent manner, which was also regulated by PMA and doxorubicin with a pattern similar to that seen in their effect on apoptosis, mitochondrial membrane potential and Bcl-2 expression, but none of these were directly affected by PMA and doxorubicin.	Tetradecanoylphorbol Acetate	94-97	caspase 3	Mus musculus	19-28
15538571-13	2005	Quercetin promoted caspase-3 activity in a dose-dependent manner, which was also regulated by PMA and doxorubicin with a pattern similar to that seen in their effect on apoptosis, mitochondrial membrane potential and Bcl-2 expression, but none of these were directly affected by PMA and doxorubicin.	Tetradecanoylphorbol Acetate	279-282	caspase 3	Mus musculus	19-28
17702895-5	2007	Importantly, silencing of the Rap1 guanine exchange factor CalDAG-GEFI inhibited SDF-1alpha- and phorbol 12-myristate 13-acetate (PMA)-induced adhesion to ICAM-1 while having no effect on adhesion to VCAM-1.	Tetradecanoylphorbol Acetate	130-133	intercellular adhesion molecule 1	Homo sapiens	155-161
1899904-2	1991	The addition of exogenous arachidonic acid to cells pretreated with TPA resulted in increased PGE2 formation, compared with basal levels, indicating an elevation in prostaglandin H synthase (PHS) activity.	Tetradecanoylphorbol Acetate	68-71	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	191-194
1899904-3	1991	PHS activity was maximal at 4 hr and was dependent upon the concentration of TPA.	Tetradecanoylphorbol Acetate	77-80	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	0-3
15734996-4	2005	Compared with Odc(+/+) mice, Odc(+/-) mice exhibit reduced epidermal ODC enzyme activity and polyamine accumulation following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	160-196	ornithine decarboxylase, structural 1	Mus musculus	29-32
1899904-5	1991	The recovery of PHS activity of cells in which the existing PHS was inhibited by aspirin was enhanced by TPA treatment.	Tetradecanoylphorbol Acetate	105-108	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	16-19
15734996-4	2005	Compared with Odc(+/+) mice, Odc(+/-) mice exhibit reduced epidermal ODC enzyme activity and polyamine accumulation following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	160-196	ornithine decarboxylase, structural 1	Mus musculus	69-72
15734996-4	2005	Compared with Odc(+/+) mice, Odc(+/-) mice exhibit reduced epidermal ODC enzyme activity and polyamine accumulation following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	198-201	ornithine decarboxylase, structural 1	Mus musculus	29-32
17974965-4	2007	Pretreatment of tumor cells with PKC inhibitors, phosphoinositide 3-kinase (PI3K) inhibitor, PKC-alpha small interfering RNA (siRNA), and short hairpin RNA abrogated phorbol 12-myristate 13-acetate-induced down-regulation of LRP and inhibited astrocytic tumor invasion in vitro.	Tetradecanoylphorbol Acetate	166-197	low density lipoprotein receptor-related protein 1	Mus musculus	225-228
1899904-5	1991	The recovery of PHS activity of cells in which the existing PHS was inhibited by aspirin was enhanced by TPA treatment.	Tetradecanoylphorbol Acetate	105-108	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	60-63
15734996-5	2005	Furthermore, following chronic TPA treatment, the characteristic hyperplastic response of the epidermis was diminished in Odc(+/-) mice.	Tetradecanoylphorbol Acetate	31-34	ornithine decarboxylase, structural 1	Mus musculus	122-125
1899904-6	1991	TPA treatment enhanced the expression of PHS mRNA, as measured by Northern analysis.	Tetradecanoylphorbol Acetate	0-3	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	41-44
1899904-7	1991	The addition of actinomycin D and cycloheximide reduced the TPA enhancement of PHS mRNA, indicating that the increase in PHS activity required de novo RNA and protein synthesis.	Tetradecanoylphorbol Acetate	60-63	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	79-82
15685366-5	2005	Results revealed that TPA treatment in CNE2 cells could upregulate the expression of "triosephosphate isomerase" and "14-3-3 protein sigma" and downregulate the expression of "reticulocalbin 1 precursor", "nucleophosmin", "mitochondrial matrix protein p1 precursor", and "stathmin".	Tetradecanoylphorbol Acetate	22-25	heat shock protein family D (Hsp60) member 1	Homo sapiens	223-254
17410540-7	2007	Moreover, sperm, which bound but did not fuse with the eggs treated with the anti-CD9 antibody KMC8, were liberated from the egg membrane after PMA, but not calphostin c, treatment.	Tetradecanoylphorbol Acetate	144-147	CD9 antigen	Mus musculus	82-85
1899904-7	1991	The addition of actinomycin D and cycloheximide reduced the TPA enhancement of PHS mRNA, indicating that the increase in PHS activity required de novo RNA and protein synthesis.	Tetradecanoylphorbol Acetate	60-63	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	121-124
15684381-6	2005	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced differentiation in HL60 cells was used to examine PTB-induced modulation of p27(Kip1) protein synthesis during differentiation.	Tetradecanoylphorbol Acetate	0-36	polypyrimidine tract binding protein 1	Homo sapiens	101-104
17786281-0	2007	Src regulates phorbol 12-myristate 13-acetate-activated PKC-induced migration via Cas/Crk/Rac1 signaling pathway in glioblastoma cells.	Tetradecanoylphorbol Acetate	14-45	Rac family small GTPase 1	Homo sapiens	90-94
15684381-6	2005	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced differentiation in HL60 cells was used to examine PTB-induced modulation of p27(Kip1) protein synthesis during differentiation.	Tetradecanoylphorbol Acetate	38-41	polypyrimidine tract binding protein 1	Homo sapiens	101-104
15455341-8	2005	We also found that topical application of PFE resulted in inhibition of TPA-induced phosphorylation of ERK1/2, p38 and JNK1/2, as well as activation of NF-kappaB and IKKalpha and phosphorylation and degradation of IkappaBalpha.	Tetradecanoylphorbol Acetate	72-75	mitogen-activated protein kinase 8	Mus musculus	119-125
17786281-2	2007	PMA treatment induced tyrosine phosphorylation of Crk-associated substrate (Cas) and formation of a complex with Crk, followed by Rac1 activation, a downstream effector of Cas/Crk complex.	Tetradecanoylphorbol Acetate	0-3	Rac family small GTPase 1	Homo sapiens	130-134
1899904-8	1991	Furthermore, pretreatment of the cells with protein kinase C inhibitors reduced the TPA-dependent stimulation of PHS activity and the expression of PHS mRNA.	Tetradecanoylphorbol Acetate	84-87	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	113-116
17635916-7	2007	Moreover, down-regulation of PKDs through RNA interference resulted in the attenuation of both basal and phorbol 12-myristate 13-acetate-induced phosphorylation, which was followed by the accumulation of SPHK2 in the nucleus in a manner rescued by PKD over-expression.	Tetradecanoylphorbol Acetate	105-136	protein kinase D1	Homo sapiens	29-32
1899904-8	1991	Furthermore, pretreatment of the cells with protein kinase C inhibitors reduced the TPA-dependent stimulation of PHS activity and the expression of PHS mRNA.	Tetradecanoylphorbol Acetate	84-87	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	148-151
1899904-9	1991	The data suggest that TPA-stimulated de novo synthesis of PHS is mediated by protein kinase C.	Tetradecanoylphorbol Acetate	22-25	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	58-61
1703443-6	1991	In addition, accumulation of c-fos mRNA by insulin/dexamethasone/methylisobutylxanthine was enhanced in protein kinase C-depleted cells pretreated with phorbol 12-myristate 13-acetate, indicating that protein kinase C may negatively regulate c-fos expression induced by insulin/dexamethasone/methylisobutylxanthine.	Tetradecanoylphorbol Acetate	152-183	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-34
17616647-4	2007	nPKCdelta in SPOC1 cells was tyrosine phosphorylated by exposure to purinergic agonist (ATPgammaS) or PMA, actions that were blocked by the Src kinase inhibitor, PP1.	Tetradecanoylphorbol Acetate	102-105	PHD finger protein 13	Homo sapiens	13-18
15544855-3	2005	NPY and PYY increased oxidative burst in phorbol myristate acetate (PMA)-stimulated macrophages involving activation of protein kinase C (PKC), and decreased it in zymosan-stimulated cells resembling inhibition of signaling pathways subsequent to binding of zymosan particles for the iC3b fragment receptor on macrophages.	Tetradecanoylphorbol Acetate	41-66	peptide YY	Rattus norvegicus	8-11
17689141-1	2007	Recently, we have shown that protein kinase C (PKC) activated by phorbol 12-myristate 13-acetate (PMA) attenuates the beta1-adrenergic receptor (beta1-AR)-mediated lipolysis in rat adipocytes.	Tetradecanoylphorbol Acetate	65-96	protein kinase C, gamma	Rattus norvegicus	29-45
15544855-3	2005	NPY and PYY increased oxidative burst in phorbol myristate acetate (PMA)-stimulated macrophages involving activation of protein kinase C (PKC), and decreased it in zymosan-stimulated cells resembling inhibition of signaling pathways subsequent to binding of zymosan particles for the iC3b fragment receptor on macrophages.	Tetradecanoylphorbol Acetate	68-71	peptide YY	Rattus norvegicus	8-11
1703443-6	1991	In addition, accumulation of c-fos mRNA by insulin/dexamethasone/methylisobutylxanthine was enhanced in protein kinase C-depleted cells pretreated with phorbol 12-myristate 13-acetate, indicating that protein kinase C may negatively regulate c-fos expression induced by insulin/dexamethasone/methylisobutylxanthine.	Tetradecanoylphorbol Acetate	152-183	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	242-247
15544855-6	2005	Additionally, it was shown that NPY Y5 receptor mediated suppression of oxidative burst in PMA- and zymosan-stimulated macrophages.	Tetradecanoylphorbol Acetate	91-94	neuropeptide Y receptor Y5	Rattus norvegicus	32-47
17689141-1	2007	Recently, we have shown that protein kinase C (PKC) activated by phorbol 12-myristate 13-acetate (PMA) attenuates the beta1-adrenergic receptor (beta1-AR)-mediated lipolysis in rat adipocytes.	Tetradecanoylphorbol Acetate	65-96	protein kinase C, gamma	Rattus norvegicus	47-50
17689141-1	2007	Recently, we have shown that protein kinase C (PKC) activated by phorbol 12-myristate 13-acetate (PMA) attenuates the beta1-adrenergic receptor (beta1-AR)-mediated lipolysis in rat adipocytes.	Tetradecanoylphorbol Acetate	98-101	protein kinase C, gamma	Rattus norvegicus	29-45
1675515-0	1991	Detection of ornithine decarboxylase gene expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin using in situ hybridization.	Tetradecanoylphorbol Acetate	56-92	ornithine decarboxylase, structural 1	Mus musculus	13-36
17689141-1	2007	Recently, we have shown that protein kinase C (PKC) activated by phorbol 12-myristate 13-acetate (PMA) attenuates the beta1-adrenergic receptor (beta1-AR)-mediated lipolysis in rat adipocytes.	Tetradecanoylphorbol Acetate	98-101	protein kinase C, gamma	Rattus norvegicus	47-50
17596302-9	2007	In BC-1, a primary effusion lymphoma cell line that is dually infected with EBV and KSHV, CHX blocked EBV BRLF1 lytic gene expression induced by TPA and sodium butyrate; KSHV ORF50 mRNA induced simultaneously in the same cells by the same inducing stimuli was resistant to CHX.	Tetradecanoylphorbol Acetate	145-148	BRLF1	Human gammaherpesvirus 4	106-111
15456774-9	2004	Furthermore, 7E4 abrogated LFA-1/ICAM-1 adhesion of phorbol 12-myristate 13-acetate-treated MOLT-4 cells.	Tetradecanoylphorbol Acetate	52-83	intercellular adhesion molecule 1	Homo sapiens	33-39
1675515-1	1991	The localization of ornithine decarboxylase gene expression in mouse skin by tumour promoter, 12-O-tetradecanoylphorbol-13-acetate, was investigated using in situ hybridization.	Tetradecanoylphorbol Acetate	94-130	ornithine decarboxylase, structural 1	Mus musculus	20-43
15491978-3	2004	We have previously shown that hCAT-1-mediated transport is decreased after protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) (Graf, P., Forstermann, U., and Closs, E. I.	Tetradecanoylphorbol Acetate	112-143	solute carrier family 7 member 1	Homo sapiens	30-36
15491978-3	2004	We have previously shown that hCAT-1-mediated transport is decreased after protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) (Graf, P., Forstermann, U., and Closs, E. I.	Tetradecanoylphorbol Acetate	145-148	solute carrier family 7 member 1	Homo sapiens	30-36
15491978-8	2004	In both Xenopus laevis oocytes and U373MG glioblastoma cells, PMA treatment promoted the internalization of hCAT-1 (fused to the enhanced green fluorescence protein (EGFP)) as visualized by fluorescence microscopy.	Tetradecanoylphorbol Acetate	62-65	solute carrier family 7 member 1	Homo sapiens	108-114
15356004-0	2004	Src tyrosine kinase inhibitor PP2 markedly enhances Ras-independent activation of Raf-1 protein kinase by phorbol myristate acetate and H2O2.	Tetradecanoylphorbol Acetate	106-131	v-raf-leukemia viral oncogene 1	Mus musculus	82-87
15356004-14	2004	This PP2 effect resulted in significant and sustained Ras-independent activation of Raf-1 by PMA and H2O2.	Tetradecanoylphorbol Acetate	93-96	v-raf-leukemia viral oncogene 1	Mus musculus	84-89
15374947-6	2004	Furthermore, TGF-beta-mediated suppression of immune cell function was exaggerated in Ahsg-/- animals, as shown by inhibition of macrophage activation and reduction in 12-O-tetradecanoylphorbol 13-acetate-induced cutaneous inflammation.	Tetradecanoylphorbol Acetate	168-204	alpha-2-HS-glycoprotein	Mus musculus	86-90
15365312-6	2004	Shedding of p75 and p55 TNF receptors (Mono Mac 6 cells) or L-selectin (Jurkat T cells) was induced by stimulation with lipopolysaccharide and phorbol myristate acetate for Mono Mac 6 cells and PMA alone for Jurkat T cells.	Tetradecanoylphorbol Acetate	143-168	TNF receptor superfamily member 1B	Homo sapiens	12-15
15322235-7	2004	Down-regulation of PKC by prolonged treatment with 1 microM 12-O-tetradecanoylphorbol-13 acetate for 24 h inhibited the potentiating action of bFGF.	Tetradecanoylphorbol Acetate	60-96	protein kinase C, gamma	Rattus norvegicus	19-22
15289320-3	2004	This cyclopentenone was able to inhibit activator protein1 (AP-1)-dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate (PMA) or c-Jun overexpression.	Tetradecanoylphorbol Acetate	141-172	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	40-58
15289320-3	2004	This cyclopentenone was able to inhibit activator protein1 (AP-1)-dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate (PMA) or c-Jun overexpression.	Tetradecanoylphorbol Acetate	141-172	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-64
15289320-3	2004	This cyclopentenone was able to inhibit activator protein1 (AP-1)-dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate (PMA) or c-Jun overexpression.	Tetradecanoylphorbol Acetate	174-177	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	40-58
15289320-3	2004	This cyclopentenone was able to inhibit activator protein1 (AP-1)-dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate (PMA) or c-Jun overexpression.	Tetradecanoylphorbol Acetate	174-177	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-64
15289320-3	2004	This cyclopentenone was able to inhibit activator protein1 (AP-1)-dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate (PMA) or c-Jun overexpression.	Tetradecanoylphorbol Acetate	174-177	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-187
15194008-4	2004	Zymographic analysis showed that emodin suppressed TPA-induced MMP-9 activity in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	51-54	matrix metallopeptidase 9	Homo sapiens	63-68
15252133-9	2004	Moreover, suppression of RACK-I expression by transfecting melanocytes with siRNA against RACK-I reduced the basal tyrosinase activity and blocked TPA-induced increases in tyrosinase activity.	Tetradecanoylphorbol Acetate	147-150	tyrosinase	Homo sapiens	172-182
15077172-4	2004	In parp-1(-/-) mice, development of papilloma-like premalignant lesions induced with DMBA and TPA, is strongly delayed and the final number of tumor-bearing mice and total tumor number were significantly reduced.	Tetradecanoylphorbol Acetate	94-97	poly (ADP-ribose) polymerase family, member 1	Mus musculus	3-9
15457682-7	2004	Although exposure of cells to prostratin or phorbol-myristate-acetate (PMA) induces the translocation of several PKC isoforms to the plasma membrane, the use of specific PKC inhibitors revealed that novel PKCs are the main mediators of the prostratin-induced CD4 down-regulation, whereas both conventional and novel PKCs contribute to CXCR4 down-regulation.	Tetradecanoylphorbol Acetate	44-69	C-X-C motif chemokine receptor 4	Homo sapiens	335-340
15457682-7	2004	Although exposure of cells to prostratin or phorbol-myristate-acetate (PMA) induces the translocation of several PKC isoforms to the plasma membrane, the use of specific PKC inhibitors revealed that novel PKCs are the main mediators of the prostratin-induced CD4 down-regulation, whereas both conventional and novel PKCs contribute to CXCR4 down-regulation.	Tetradecanoylphorbol Acetate	71-74	C-X-C motif chemokine receptor 4	Homo sapiens	335-340
15481789-4	2004	Administration of 12-o-tetradecanoyl- phorbol-13-acetate (TPA) increased the release of MMP-9 but not of MMP-2.	Tetradecanoylphorbol Acetate	18-56	matrix metallopeptidase 9	Homo sapiens	88-93
15481789-4	2004	Administration of 12-o-tetradecanoyl- phorbol-13-acetate (TPA) increased the release of MMP-9 but not of MMP-2.	Tetradecanoylphorbol Acetate	58-61	matrix metallopeptidase 9	Homo sapiens	88-93
15481789-6	2004	Moreover, the increased level of MMP-9 by TPA in breast cancer was also higher than that in adjacent normal breast tissue and fibroadenoma.	Tetradecanoylphorbol Acetate	42-45	matrix metallopeptidase 9	Homo sapiens	33-38
15147830-3	2004	The MEK inhibitor U0126 (0.1 to 10 microM) enhanced the TPA-induced ICAM-1 expression but not the IFN-gamma-induced one.	Tetradecanoylphorbol Acetate	56-59	intercellular adhesion molecule 1	Homo sapiens	68-74
15147830-5	2004	Furthermore, PD98059 (0.5 to 50 microM), another MEK inhibitor, enhanced the TPA-induced ICAM-1 expression as well.	Tetradecanoylphorbol Acetate	77-80	intercellular adhesion molecule 1	Homo sapiens	89-95
15147830-7	2004	BAY11-7082, an inhibitor of nuclear factor kappaB (NF-kappaB) activation, and MG132, a 26S proteasome inhibitor, reduced the TPA-induced ICAM-1 expression but not the IFN-gamma-induced one.	Tetradecanoylphorbol Acetate	125-128	intercellular adhesion molecule 1	Homo sapiens	137-143
15251408-8	2004	At 30 and 120 min after PMA/ionomycin stimulation, 55 +/- 14% and 42 +/- 14%, respectively, of CD8(hi+) CTLs still stained perforin(+) (time point 0 min = 100%).	Tetradecanoylphorbol Acetate	24-27	CD8a molecule	Homo sapiens	95-98
15175502-6	2004	While indolactam-mediated PKC activation stimulates membrane assembly of both TJ proteins, TPA-mediated PKC activation stimulates only that of ZO-1alpha(+).	Tetradecanoylphorbol Acetate	91-94	protein kinase C, delta	Mus musculus	104-107
15033975-2	2004	Increased caspase-3 activity associated with apoptosis was found in the skin of wild-type mice after tumor promotion with 12-O-tetradecanoylphorbol-13-acetate, and this effect was diminished in PPARbeta-null mice.	Tetradecanoylphorbol Acetate	122-158	caspase 3	Mus musculus	10-19
15117853-3	2004	METHODS AND RESULTS: ST2 levels were measured in serum from 810 patients with acute myocardial infarction in the Thrombolysis In Myocardial Infarction (TIMI) 14 (362 patients) and Enoxaparin and TNK-tPA With or Without GPIIb/IIIa Inhibitor as Reperfusion Strategy in STEMI (ENTIRE)-TIMI 23 (448 patients) clinical trials.	Tetradecanoylphorbol Acetate	199-202	ST2	Homo sapiens	21-24
15081401-0	2004	Single-nucleotide polymorphism g.1548G &gt; A (E469K) in human ICAM-1 gene affects mRNA splicing pattern and TPA-induced apoptosis.	Tetradecanoylphorbol Acetate	109-112	intercellular adhesion molecule 1	Homo sapiens	63-69
15048868-6	2004	In addition, inhibition of conventional and novel PKC isoforms by chronic (24 h) exposure to phorbol 12-myristate 13-acetate (PMA) inhibited AVP-induced activation of ERK and p70S6 kinase as well as EGF-R phosphorylation.	Tetradecanoylphorbol Acetate	93-124	epidermal growth factor receptor	Rattus norvegicus	199-204
15048868-6	2004	In addition, inhibition of conventional and novel PKC isoforms by chronic (24 h) exposure to phorbol 12-myristate 13-acetate (PMA) inhibited AVP-induced activation of ERK and p70S6 kinase as well as EGF-R phosphorylation.	Tetradecanoylphorbol Acetate	126-129	epidermal growth factor receptor	Rattus norvegicus	199-204
14709331-4	2004	In addition, in cells depleted of diacylglycerol-sensitive PKC by prolonged treatment with 4beta-phorbol 12beta-myristate 13alpha-acetate (PMA), the stimulatory effects of PGF2alpha on glucose transport and GLUT1 mRNA accumulation were both inhibited.	Tetradecanoylphorbol Acetate	139-142	solute carrier family 2 member 1	Homo sapiens	207-212
15287155-0	2004	Exogenous prostaglandin E2 inhibits TPA induced matrix metalloproteinase-9 production in MCF-7 cells.	Tetradecanoylphorbol Acetate	36-39	matrix metallopeptidase 9	Homo sapiens	48-74
15287155-3	2004	TPA induced a strong production of MMP-9 while exogenous PGE2 had no effect on the basal MMP-9 level, but inhibited the TPA induced enzyme expression and matrigel invasiveness.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	35-40
14670076-9	2004	In addition, rat embryo fibroblasts overexpressing syndecan-4 exhibited a slowed down-regulation of PKC-alpha in response either to a prolonged treatment with PMA or to maintaining cells in suspension culture.	Tetradecanoylphorbol Acetate	159-162	protein kinase C, alpha	Rattus norvegicus	100-109
14676211-9	2004	In a transfected cell-based sheddase assay, ADAM33 functioned as a negative regulator of APP shedding and mediated some constitutive shedding of KL-1, which was not regulated by phorbol 12-myristate 13-acetate activation.	Tetradecanoylphorbol Acetate	178-209	ADAM metallopeptidase domain 33	Homo sapiens	44-50
15025540-4	2004	This is more particularly the case when the nonspecific transfection pathways are minimized (i.e. for N/P &lt;or= 2.5 AMD-labeled polyplexes) and in the presence of phorbol myristate acetate which triggers CXCR4 receptor endocytosis of the AMD-labeled polyplexes to a larger extent than that of their respective nonlabeled ones.	Tetradecanoylphorbol Acetate	165-190	C-X-C motif chemokine receptor 4	Homo sapiens	206-211
15067739-1	2004	OBJECTIVE: To investigate the effect of mitogen Phorbol 12-myristate 13-Acetate (PMA) on CD3, CD4 and CD8 expression of human T-lymphocytes.	Tetradecanoylphorbol Acetate	48-79	CD8a molecule	Homo sapiens	102-105
15067739-1	2004	OBJECTIVE: To investigate the effect of mitogen Phorbol 12-myristate 13-Acetate (PMA) on CD3, CD4 and CD8 expression of human T-lymphocytes.	Tetradecanoylphorbol Acetate	81-84	CD8a molecule	Homo sapiens	102-105
17443671-5	2007	In TF-1-fms cells expressing HIV-1 Nef protein in a conditionally active-manner, both M-CSF-mediated proliferation and M-CSF/TPA-mediated differentiation were inhibited by the activation of Nef.	Tetradecanoylphorbol Acetate	125-128	Nef	Human immunodeficiency virus 1	35-38
17443671-5	2007	In TF-1-fms cells expressing HIV-1 Nef protein in a conditionally active-manner, both M-CSF-mediated proliferation and M-CSF/TPA-mediated differentiation were inhibited by the activation of Nef.	Tetradecanoylphorbol Acetate	125-128	Nef	Human immunodeficiency virus 1	190-193
17372274-11	2007	The present study revealed that topical application of SP600125, a pharmacological inhibitor of c-Jun-N-terminal kinase (JNK), abrogated the activation of AP-1 and the expression of COX-2 in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	191-194	mitogen-activated protein kinase 8	Mus musculus	96-119
17372274-11	2007	The present study revealed that topical application of SP600125, a pharmacological inhibitor of c-Jun-N-terminal kinase (JNK), abrogated the activation of AP-1 and the expression of COX-2 in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	191-194	mitogen-activated protein kinase 8	Mus musculus	121-124
17372274-12	2007	Taken together, humulone suppressed TPA-induced activation of NF-kappaB and AP-1 and subsequent expression of COX-2 by blocking upstream kinases IKK and JNK, respectively, which may account for its antitumor-promoting effects on mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	36-39	mitogen-activated protein kinase 8	Mus musculus	153-156
17482559-7	2007	Further mechanistic investigations revealed that short-term treatment (2 h) of cells with protein phosphatase 1/2A inhibitor okadaic acid (80.5 ng/ml) and proteinkinase C inducer phorbol 12-myristate 13-acetate (PMA; 0.62 microg/ml) almost abolished Rfc1 mediated MTX uptake.	Tetradecanoylphorbol Acetate	179-210	replication factor C subunit 1	Rattus norvegicus	250-254
17355247-10	2007	Moreover, leptin enhanced the expression of CD69 and CD25 on CD4(+) and CD8(+) cells after stimulation with PMA-ionomycin.	Tetradecanoylphorbol Acetate	108-111	CD8a molecule	Homo sapiens	72-75
17398109-6	2007	RESULTS: Patients with low levels of preoperative basal neutrophil CD11b expression had the greatest increase in CD11b following phorbol-12-myristate-13-acetate stimulation.	Tetradecanoylphorbol Acetate	129-160	integrin subunit alpha M	Homo sapiens	67-72
17398109-6	2007	RESULTS: Patients with low levels of preoperative basal neutrophil CD11b expression had the greatest increase in CD11b following phorbol-12-myristate-13-acetate stimulation.	Tetradecanoylphorbol Acetate	129-160	integrin subunit alpha M	Homo sapiens	113-118
17485888-7	2007	Treatment of the cells with phorbol 12-myristate 13-acetate, which induces the differentiation of the cells into macrophage-like cells, significantly enhanced the IFN-gamma -induced RIG-I expression.	Tetradecanoylphorbol Acetate	28-59	DExD/H-box helicase 58	Homo sapiens	182-187
17409628-8	2007	Moreover, the cell-permeable cAMP analog, 8-bromo cAMP (10(-7) M), and phorbol 12-myristate 13 acetate (10(-7) M) potentiated HGF-induced MAPK phosphorylation.	Tetradecanoylphorbol Acetate	71-102	hepatocyte growth factor	Rattus norvegicus	126-129
17425422-8	2007	With PMA/ionomycin stimulation, the percent IL-17 expression in CD4(+) cells (median) was 1.45 versus 0.65 (p&lt; 0.0001) and in CD4() T cells it was 1.0 versus 0.12 (p&lt; 0.0001).	Tetradecanoylphorbol Acetate	5-8	interleukin 17A	Homo sapiens	44-49
17425422-10	2007	IL-17 expression was further inducible by PMA/ionomycin stimulation in vitro only in CD4(+) T cells.	Tetradecanoylphorbol Acetate	42-45	interleukin 17A	Homo sapiens	0-5
17227757-19	2007	The potential biological relevance of the hBVR activation of PKC betaII was suggested by the finding that in cells transfected with the PKC betaII, hBVR augmented phorbol myristate acetate-mediated c-fos expression, and infection with sihBVR attenuated the response.	Tetradecanoylphorbol Acetate	163-188	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	198-203
17227757-20	2007	Also, in cells overexpressing hBVR and PKC betaII, as well as in untransfected cells, upon treatment with phorbol myristate acetate, the PKC translocated to the plasma membrane and co-localized with hBVR.	Tetradecanoylphorbol Acetate	106-131	protein kinase C zeta	Homo sapiens	39-42
17214970-4	2007	Silibinin has been found to inhibit PMA-induced MMP-9 gene transcriptional activity by blocking the activation of AP-1 via MAPK signaling pathways.	Tetradecanoylphorbol Acetate	36-39	matrix metallopeptidase 9	Homo sapiens	48-53
17214970-6	2007	These results suggest that silibinin represents a potential anti-metastatic agent suppressing PMA-induced cancer cell invasion through the specific inhibition of AP-1-dependent MMP-9 gene expression.	Tetradecanoylphorbol Acetate	94-97	matrix metallopeptidase 9	Homo sapiens	177-182
17182622-4	2007	Klk8 mRNA as well as Klk6 and Klk7 mRNA were up-regulated after 12-O-tetradecanoylphorbol-13-acetate application in the WT mice.	Tetradecanoylphorbol Acetate	64-100	kallikrein related-peptidase 6	Mus musculus	21-25
17103408-7	2007	A significant increase in Th1 and Th2 CD4+ T cells was observed in the patients after ex vivo stimulation with phorbol 12-myristate 13-acetate /ionomycin.	Tetradecanoylphorbol Acetate	111-142	negative elongation factor complex member C/D	Homo sapiens	26-29
17155946-4	2007	Phorbol-12-myristate 13-acetate (PMA)-stimulated EPCR shedding is reduced by approximately 50% in HEK293 cells transfected with human EPCR cDNA and by 60% in human umbilical vein endothelial cells after transfection of TACE small interfering RNA (siRNA) into these cells.	Tetradecanoylphorbol Acetate	0-31	ADAM metallopeptidase domain 17	Homo sapiens	219-223
17404068-7	2007	Since the transcription factor activator protein-1 (AP-1) plays a role in tumor promotion and is also known to regulate COX-2 induction, we attempted to determine the effect of KG-135 on TPA-induced activation of AP-1.	Tetradecanoylphorbol Acetate	187-190	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-50
17404068-7	2007	Since the transcription factor activator protein-1 (AP-1) plays a role in tumor promotion and is also known to regulate COX-2 induction, we attempted to determine the effect of KG-135 on TPA-induced activation of AP-1.	Tetradecanoylphorbol Acetate	187-190	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	213-217
17404068-8	2007	Cotreatment with KG-135 resulted in a decrease in TPA-induced DNA binding of AP-1.	Tetradecanoylphorbol Acetate	50-53	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-81
17404068-11	2007	Taken together, the above findings suggest that KG-135 inhibits TPA-induced COX-2 expression in MCF-10A cells by blocking the JNK/AP-1 signaling pathway.	Tetradecanoylphorbol Acetate	64-67	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-134
17065239-1	2007	The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to the tumor promoter phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	114-145	epilepsy 4	Mus musculus	11-14
17065239-1	2007	The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to the tumor promoter phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	147-150	epilepsy 4	Mus musculus	11-14
17173184-2	2006	Although the original work showed that PLSCR1 contributes to the transbilayer movement of phospholipids, the following studies revealed that PLSCR1 expression can be induced by some cytokines such as interferon, epidermal growth factor, and also by leukemic cell differentiation-inducing agents such as all-trans retinoic acid (ATRA) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	338-369	phospholipid scramblase 1	Homo sapiens	141-147
17173184-2	2006	Although the original work showed that PLSCR1 contributes to the transbilayer movement of phospholipids, the following studies revealed that PLSCR1 expression can be induced by some cytokines such as interferon, epidermal growth factor, and also by leukemic cell differentiation-inducing agents such as all-trans retinoic acid (ATRA) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	371-374	phospholipid scramblase 1	Homo sapiens	141-147
17187679-9	2006	Furthermore, TPA-induced S100A9 gene expression in HaCaT keratinocytes was blocked after the pharmacologic inhibition of PARP-1 with 1,5-isoquinolinediol (DiQ).	Tetradecanoylphorbol Acetate	13-16	S100 calcium binding protein A9	Homo sapiens	25-31
17106253-9	2006	Dot blot indicated that Bicyclol inhibited mRNA expressions of H-ras, c-myc and PKCalpha genes by TPA-stimulation.	Tetradecanoylphorbol Acetate	98-101	protein kinase C, alpha	Rattus norvegicus	80-88
16973724-9	2006	PKD phosphorylation was also dose-dependently increased by the PKC activator phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	77-108	protein kinase D1	Homo sapiens	0-3
16987961-8	2006	In contrast, treatment by bisindolylmaleimide, Go6976, and rottlerin, and chronic application of phorbol 12-myristate 13-acetate and/or bryostatin-1 indicated that PKC delta mediated PEA-15 inhibition of astrocyte migration.	Tetradecanoylphorbol Acetate	97-128	protein kinase C, delta	Mus musculus	164-173
16757545-7	2006	Stimulation of PKC using the phorbol ester 12-O-tetradecanoylphorbol 13-acetate caused a rapid, significant (P &lt; or = 0.05) increase in c-Jun and c-Fos concentrations but a significant decrease in mRNA for OTR within 6 h followed by a significant decrease in OT binding by 24 h. Adenoviral infection of the cells with expression vectors for c-Jun and c-Fos increased the AP-1 subunits but had no effect on OTR expression.	Tetradecanoylphorbol Acetate	43-79	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	139-144
16757545-7	2006	Stimulation of PKC using the phorbol ester 12-O-tetradecanoylphorbol 13-acetate caused a rapid, significant (P &lt; or = 0.05) increase in c-Jun and c-Fos concentrations but a significant decrease in mRNA for OTR within 6 h followed by a significant decrease in OT binding by 24 h. Adenoviral infection of the cells with expression vectors for c-Jun and c-Fos increased the AP-1 subunits but had no effect on OTR expression.	Tetradecanoylphorbol Acetate	43-79	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	149-154
16757545-7	2006	Stimulation of PKC using the phorbol ester 12-O-tetradecanoylphorbol 13-acetate caused a rapid, significant (P &lt; or = 0.05) increase in c-Jun and c-Fos concentrations but a significant decrease in mRNA for OTR within 6 h followed by a significant decrease in OT binding by 24 h. Adenoviral infection of the cells with expression vectors for c-Jun and c-Fos increased the AP-1 subunits but had no effect on OTR expression.	Tetradecanoylphorbol Acetate	43-79	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	344-349
16757545-7	2006	Stimulation of PKC using the phorbol ester 12-O-tetradecanoylphorbol 13-acetate caused a rapid, significant (P &lt; or = 0.05) increase in c-Jun and c-Fos concentrations but a significant decrease in mRNA for OTR within 6 h followed by a significant decrease in OT binding by 24 h. Adenoviral infection of the cells with expression vectors for c-Jun and c-Fos increased the AP-1 subunits but had no effect on OTR expression.	Tetradecanoylphorbol Acetate	43-79	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	354-359
17072500-4	2006	The treatment of tumor cells with two NF-kappaB inducers, tumor necrosis factor-alpha and phorbol 12-myristate 13-acetate, decreased HLA-G1 cell surface expression but increased intracytoplasmic HLA-G proteins.	Tetradecanoylphorbol Acetate	90-121	major histocompatibility complex, class I, G	Homo sapiens	133-139
17072500-4	2006	The treatment of tumor cells with two NF-kappaB inducers, tumor necrosis factor-alpha and phorbol 12-myristate 13-acetate, decreased HLA-G1 cell surface expression but increased intracytoplasmic HLA-G proteins.	Tetradecanoylphorbol Acetate	90-121	major histocompatibility complex, class I, G	Homo sapiens	133-138
16475165-0	2006	Knockdown of NFAT3 blocked TPA-induced COX-2 and iNOS expression, and enhanced cell transformation in Cl41 cells.	Tetradecanoylphorbol Acetate	27-30	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4	Mus musculus	13-18
16475165-5	2006	In this study, we used a small interfering RNA (siRNA) expression construct to study the role of NFAT3 in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell transformation with the tumor promotion-sensitive mouse epidermal Cl41 cells.	Tetradecanoylphorbol Acetate	110-146	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4	Mus musculus	97-102
16475165-5	2006	In this study, we used a small interfering RNA (siRNA) expression construct to study the role of NFAT3 in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell transformation with the tumor promotion-sensitive mouse epidermal Cl41 cells.	Tetradecanoylphorbol Acetate	148-151	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4	Mus musculus	97-102
16475165-6	2006	Our results showed that TPA was able to induce NFAT3 activation in Cl41 cells.	Tetradecanoylphorbol Acetate	24-27	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4	Mus musculus	47-52
16475165-9	2006	However, anchorage-independent transformation in response to TPA was significantly enhanced in NFAT3 siRNA stable transfectants as compared with vector transfectants.	Tetradecanoylphorbol Acetate	61-64	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4	Mus musculus	95-100
16891616-4	2006	PACAP38 and GIF ameliorated the production of microglia-derived reactive oxygen species (ROS), where both LPS- and phorbol 12-myristate 13-acetate-induced superoxide and intracellular ROS were inhibited.	Tetradecanoylphorbol Acetate	115-146	cobalamin binding intrinsic factor	Rattus norvegicus	12-15
16962263-4	2006	The effect of BaP on the Hsp70 expression level was markedly attenuated by co-treatment with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	93-124	heat shock protein family A (Hsp70) member 4	Homo sapiens	25-30
16962263-4	2006	The effect of BaP on the Hsp70 expression level was markedly attenuated by co-treatment with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	126-129	heat shock protein family A (Hsp70) member 4	Homo sapiens	25-30
16945329-4	2006	PPARgamma expression in response to TPA was attenuated by pretreatment with bisindolylmaleimide I, N-acetyl-L-cysteine (NAC) and PD98059.	Tetradecanoylphorbol Acetate	36-39	X-linked Kx blood group	Homo sapiens	120-123
16945329-6	2006	Pretreatment with bisindolylmaleimide I or NAC blocked TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK), suggesting that ERK-mediated signaling is also involved in the induction of PPARgamma.	Tetradecanoylphorbol Acetate	55-58	X-linked Kx blood group	Homo sapiens	43-46
16930678-6	2006	Single particle tracking reveals that the average ICAM-1 mobility is 44% less in late than early passage cells after its motion is stimulated by the Protein Kinase C (PKC) activator, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	183-208	intercellular adhesion molecule 1	Homo sapiens	50-56
16930678-6	2006	Single particle tracking reveals that the average ICAM-1 mobility is 44% less in late than early passage cells after its motion is stimulated by the Protein Kinase C (PKC) activator, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	210-213	intercellular adhesion molecule 1	Homo sapiens	50-56
16969515-7	2006	Furthermore, it showed that AT inhibited the TPA-induced expression of COX-2 protein and ornithine decarboxylase (ODC) activity in epidermis.	Tetradecanoylphorbol Acetate	45-48	ornithine decarboxylase, structural 1	Mus musculus	89-112
16969515-7	2006	Furthermore, it showed that AT inhibited the TPA-induced expression of COX-2 protein and ornithine decarboxylase (ODC) activity in epidermis.	Tetradecanoylphorbol Acetate	45-48	ornithine decarboxylase, structural 1	Mus musculus	114-117
1675515-4	1991	These results indicate that the epidermal cells are mainly responsible for the activation of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	120-156	ornithine decarboxylase, structural 1	Mus musculus	93-116
16835219-3	2006	In contrast to other cellular sialidases Neu2, Neu3, and Neu4, whose expression either remains unchanged or is down-regulated, Neu1 mRNA, protein and activity are specifically increased during the phorbol 12-myristate 13-acetate-induced differentiation, consistent with a significant induction of the transcriptional activity of the Neu1 gene promoter.	Tetradecanoylphorbol Acetate	197-228	neuraminidase 3	Homo sapiens	47-51
1898633-8	1991	These results suggest that the protein complex binding to the DSE regulatory element is the target for c-fos activation by TPA and inhibition by hemin in K 562 cells.	Tetradecanoylphorbol Acetate	123-126	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-108
16607275-5	2006	Overexpression of the EP2 receptor increased TPA-induced keratinocyte proliferation both in vivo and in vitro.	Tetradecanoylphorbol Acetate	45-48	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	22-34
16607275-6	2006	In addition, the epidermis of EP2 TG mice 48 h after topical TPA treatment was significantly thicker compared to that of WT mice.	Tetradecanoylphorbol Acetate	61-64	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	30-33
16607275-8	2006	The inflammatory response to TPA was increased in EP2 TG mice, as demonstrated by an increased number of macrophages in the dermis.	Tetradecanoylphorbol Acetate	29-32	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	50-53
1822395-1	1991	We show here that TPA treatment of MCF-7 cells represses estrogen receptor dependent transcriptional activity, while increasing the AP1 binding activity.	Tetradecanoylphorbol Acetate	18-21	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-135
16777970-5	2006	Furthermore, PKC activation by phorbol 12-myristate 13-acetate (PMA) produced an extremely high level of CNP mRNA that was abolished by GF109203X.	Tetradecanoylphorbol Acetate	31-62	natriuretic peptide C	Homo sapiens	105-108
16777970-5	2006	Furthermore, PKC activation by phorbol 12-myristate 13-acetate (PMA) produced an extremely high level of CNP mRNA that was abolished by GF109203X.	Tetradecanoylphorbol Acetate	64-67	natriuretic peptide C	Homo sapiens	105-108
1822395-5	1991	Our results suggest that the inhibition of TPA of the estrogen dependent growth of the MCF-7 cells is caused by over expression of cJun and cFos.	Tetradecanoylphorbol Acetate	43-46	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-135
1822395-5	1991	Our results suggest that the inhibition of TPA of the estrogen dependent growth of the MCF-7 cells is caused by over expression of cJun and cFos.	Tetradecanoylphorbol Acetate	43-46	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-144
1830012-4	1991	Leucocyte common antigen (CD45) cell surface expression was quantitatively increased on MOLT-4 cells by TPA induction, unaltered by rIFN and up-regulated by combined action of TPA and rIFN.	Tetradecanoylphorbol Acetate	104-107	protein tyrosine phosphatase receptor type C	Homo sapiens	26-30
17090476-2	2006	The authors determined the time course of activation and downregulation of PKCepsilon by the known PKC activator phorbol 12-myristate 13-acetate (PMA) and demonstrate that chemical inhibition of PKC by calphostin C or the novel PKC isoform inhibitor Ro 31-8220 induced striking detachment of ciliated BBECs from the basal cell monolayer within 1 hour, independent of apoptosis or necrotic cell death.	Tetradecanoylphorbol Acetate	113-144	protein kinase C epsilon	Bos taurus	75-85
17090476-2	2006	The authors determined the time course of activation and downregulation of PKCepsilon by the known PKC activator phorbol 12-myristate 13-acetate (PMA) and demonstrate that chemical inhibition of PKC by calphostin C or the novel PKC isoform inhibitor Ro 31-8220 induced striking detachment of ciliated BBECs from the basal cell monolayer within 1 hour, independent of apoptosis or necrotic cell death.	Tetradecanoylphorbol Acetate	113-144	protein kinase C epsilon	Bos taurus	75-78
17090476-2	2006	The authors determined the time course of activation and downregulation of PKCepsilon by the known PKC activator phorbol 12-myristate 13-acetate (PMA) and demonstrate that chemical inhibition of PKC by calphostin C or the novel PKC isoform inhibitor Ro 31-8220 induced striking detachment of ciliated BBECs from the basal cell monolayer within 1 hour, independent of apoptosis or necrotic cell death.	Tetradecanoylphorbol Acetate	146-149	protein kinase C epsilon	Bos taurus	75-85
17090476-2	2006	The authors determined the time course of activation and downregulation of PKCepsilon by the known PKC activator phorbol 12-myristate 13-acetate (PMA) and demonstrate that chemical inhibition of PKC by calphostin C or the novel PKC isoform inhibitor Ro 31-8220 induced striking detachment of ciliated BBECs from the basal cell monolayer within 1 hour, independent of apoptosis or necrotic cell death.	Tetradecanoylphorbol Acetate	146-149	protein kinase C epsilon	Bos taurus	75-78
17090476-2	2006	The authors determined the time course of activation and downregulation of PKCepsilon by the known PKC activator phorbol 12-myristate 13-acetate (PMA) and demonstrate that chemical inhibition of PKC by calphostin C or the novel PKC isoform inhibitor Ro 31-8220 induced striking detachment of ciliated BBECs from the basal cell monolayer within 1 hour, independent of apoptosis or necrotic cell death.	Tetradecanoylphorbol Acetate	146-149	protein kinase C epsilon	Bos taurus	99-102
1830012-4	1991	Leucocyte common antigen (CD45) cell surface expression was quantitatively increased on MOLT-4 cells by TPA induction, unaltered by rIFN and up-regulated by combined action of TPA and rIFN.	Tetradecanoylphorbol Acetate	176-179	protein tyrosine phosphatase receptor type C	Homo sapiens	26-30
17090476-2	2006	The authors determined the time course of activation and downregulation of PKCepsilon by the known PKC activator phorbol 12-myristate 13-acetate (PMA) and demonstrate that chemical inhibition of PKC by calphostin C or the novel PKC isoform inhibitor Ro 31-8220 induced striking detachment of ciliated BBECs from the basal cell monolayer within 1 hour, independent of apoptosis or necrotic cell death.	Tetradecanoylphorbol Acetate	146-149	protein kinase C epsilon	Bos taurus	99-102
1830012-5	1991	CD8 antigen was down-regulated by both TPA and rIFN.	Tetradecanoylphorbol Acetate	39-42	CD8a molecule	Homo sapiens	0-3
1898656-1	1991	Phorbol myristate acetate-induced accumulation of adenosine owing to inactivation of extracellularly released adenosine deaminase.	Tetradecanoylphorbol Acetate	0-25	adenosine deaminase	Homo sapiens	110-129
16763098-8	2006	The IMD-induced effects were abolished by the protein kinase C inhibitor chelerythrine (1 microM), downregulation of protein kinase C using phorbol 12-myristate 13-acetate (1 microM), and the protein kinase A inhibitor H89 (1 microM).	Tetradecanoylphorbol Acetate	140-171	adrenomedullin 2	Mus musculus	4-7
1898656-9	1991	PMA stimulation also provoked an inactivation of extracellular adenosine deaminase, purine nucleoside phosphorylase, and lactate dehydrogenase in PMN suspensions.	Tetradecanoylphorbol Acetate	0-3	adenosine deaminase	Homo sapiens	63-82
1898656-10	1991	We concluded that PMNs, even when not stimulated, continuously produce adenosine by dephosphorylation of extracellularly released adenylates; and that stimulation of PMNs by PMA causes adenosine accumulation owing to the inactivation of adenosine deaminase released by broken cells.	Tetradecanoylphorbol Acetate	174-177	adenosine deaminase	Homo sapiens	237-256
1716733-4	1991	It has been found that in E1Aad5 + cHa-ras-transformed cells the expression of c-fos promoter has a constitutive, non-inducible character while in REF cells and cells immortalized by E1Aad5 the fos-promoter can be regulated by serum growth factors, EGF, and TPA.	Tetradecanoylphorbol Acetate	258-261	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	79-84
16877364-4	2006	Here we report that treatment with 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate induced metastatic melanomas in all HGF/SF mice on the C57BL/6 background, which histologically resemble human melanoma.	Tetradecanoylphorbol Acetate	70-106	hepatocyte growth factor	Mus musculus	143-149
16818732-2	2006	In contrast to B-2 cells, cyclin D2 is up-regulated in a rapid and transient manner in phorbol ester (PMA)-stimulated B-1a cells, whereas cyclin D3 does not accumulate until late G(1) phase.	Tetradecanoylphorbol Acetate	102-105	cyclin D2	Mus musculus	26-35
1701978-2	1990	Because adenosine 3",5"-cyclic monophosphate (cAMP) and phorbol myristate acetate (PMA) activate Cl- channels via phosphorylation by cAMP-dependent protein kinase and protein kinase C, respectively, we asked whether Ca2(+)-dependent Cl- channel activation is phosphorylation dependent.	Tetradecanoylphorbol Acetate	56-81	carbonic anhydrase 2	Homo sapiens	216-219
16773182-4	2006	Phorbol 12-myrisate 13-acetate (PMA) increased MUC5AC mRNA expression and transcriptional activities of MUC5AC promoter-reporter deletion constructs containing AP-1 consensus sites.	Tetradecanoylphorbol Acetate	32-35	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	160-164
1701978-2	1990	Because adenosine 3",5"-cyclic monophosphate (cAMP) and phorbol myristate acetate (PMA) activate Cl- channels via phosphorylation by cAMP-dependent protein kinase and protein kinase C, respectively, we asked whether Ca2(+)-dependent Cl- channel activation is phosphorylation dependent.	Tetradecanoylphorbol Acetate	83-86	carbonic anhydrase 2	Homo sapiens	216-219
16611631-5	2006	Stimulation of neuroblastoma cells with IGF1 or TPA decreases GSK3 activity concomitantly with CRMP2 and CRMP4 phosphorylation.	Tetradecanoylphorbol Acetate	48-51	dihydropyrimidinase like 3	Homo sapiens	105-110
2128972-4	1990	tPA production by HOMC was also stimulated by phorbol 12-myristate 13-acetate (2.6-fold), fibrin clots (1.9-fold), or batroxobin (1.9-fold).	Tetradecanoylphorbol Acetate	46-77	chromosome 20 open reading frame 181	Homo sapiens	0-3
16368122-5	2006	Arsenic/TPA treatment resulted in increased expression of alpha-fetoprotein, k-ras, c-myc, estrogen receptor-alpha, cyclin D1, cdk2na, plasminogen activator inhibitor-1, cytokeratin-8, cytokeratin-18, glutathione S-transferases and insulin-like growth factor binding proteins in liver and liver tumors from both male and female mice.	Tetradecanoylphorbol Acetate	8-11	alpha fetoprotein	Mus musculus	58-75
16368122-5	2006	Arsenic/TPA treatment resulted in increased expression of alpha-fetoprotein, k-ras, c-myc, estrogen receptor-alpha, cyclin D1, cdk2na, plasminogen activator inhibitor-1, cytokeratin-8, cytokeratin-18, glutathione S-transferases and insulin-like growth factor binding proteins in liver and liver tumors from both male and female mice.	Tetradecanoylphorbol Acetate	8-11	cyclin D1	Mus musculus	116-125
16368122-6	2006	Arsenic/TPA also decreased the expression of BRCA1, betaine-homocysteine methyltransferase, CYP7B1, CYP2F2 and insulin-like growth factor-1 in normal and cancerous livers.	Tetradecanoylphorbol Acetate	8-11	breast cancer 1, early onset	Mus musculus	45-50
16368122-6	2006	Arsenic/TPA also decreased the expression of BRCA1, betaine-homocysteine methyltransferase, CYP7B1, CYP2F2 and insulin-like growth factor-1 in normal and cancerous livers.	Tetradecanoylphorbol Acetate	8-11	cytochrome P450, family 7, subfamily b, polypeptide 1	Mus musculus	92-98
2174364-3	1990	Down regulation of protein kinase C by prolonged exposure of hepatoma cells to TPA causes a dramatic decrease in the glucagon-stimulated effect on Ki-ras expression.	Tetradecanoylphorbol Acetate	79-82	KRAS proto-oncogene, GTPase	Rattus norvegicus	147-153
16698993-8	2006	(iv) BZLF1 was specifically coimmunoprecipitated with BGLF4 in 12-O-tetradecanoylphorbol-13-acetate-treated B95-8 cells and in COS-1 cells transiently expressing both of these viral proteins.	Tetradecanoylphorbol Acetate	63-99	tegument serine/threonine protein kinase	Human gammaherpesvirus 4	54-59
2266662-7	1990	Activation of protein kinase C (PKC) by phorbol myristate acetate (PMA) also decreased C-mediated cytolysis.	Tetradecanoylphorbol Acetate	40-65	protein kinase C, gamma	Rattus norvegicus	14-30
16481048-8	2006	In addition, CD5+/Mac-1- peritoneal B cells responded to PMA, a mitogen that stimulates B-1 cells but not B-2 cells, and not to anti-Ig, that stimulates B-2 cells but not B-1 cells.	Tetradecanoylphorbol Acetate	57-60	CD5 antigen	Mus musculus	13-16
16651411-9	2006	In the presence of TPA, whereas ERalpha was not bound to the promoter, a strong association of acetylated and/or phospho-H3, MSK1, and c-Jun was observed.	Tetradecanoylphorbol Acetate	19-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	135-140
1710077-5	1990	CDw50 is a poorly or non-constitutively phosphorylated molecule that becomes phosphorylated by treatment with phorbol 12-myristate 13-acetate (PMA) of peripheral blood mononuclear cells (PBMC).	Tetradecanoylphorbol Acetate	110-141	intercellular adhesion molecule 3	Homo sapiens	0-5
16675300-6	2006	The delayed synthesis of PGE2 and PGF2alpha following the stimulation for 24 with a mixture of PMA and calcium ionophore A23187 was the highest in preadipocytes, reflecting the increased expression levels of cPLA2alpha and COX-2.	Tetradecanoylphorbol Acetate	95-98	phospholipase A2 group IVA	Homo sapiens	208-218
1710077-5	1990	CDw50 is a poorly or non-constitutively phosphorylated molecule that becomes phosphorylated by treatment with phorbol 12-myristate 13-acetate (PMA) of peripheral blood mononuclear cells (PBMC).	Tetradecanoylphorbol Acetate	143-146	intercellular adhesion molecule 3	Homo sapiens	0-5
16374778-6	2006	PMA, which mimics diacylglycerol (DAG) as an activator of cPKC, novel-PKC (nPKC), and non-PKC DAG-driven molecule(s), produced a dose-dependent dual effect on phagocytosis by CR3/MAC-1 and SRAI/II, i.e., augmentation at low concentrations and inhibition at high concentrations.	Tetradecanoylphorbol Acetate	0-3	integrin subunit alpha M	Homo sapiens	179-184
1698561-5	1990	On the other hand, on CEM III cells TPA induced no modulation of CD5 antigen, a less dramatic effect on cell growth and cell cycle, but a CD7 downregulation.	Tetradecanoylphorbol Acetate	36-39	CD7 molecule	Homo sapiens	138-141
16374778-7	2006	Inhibition of phagocytosis by CR3/MAC-1 was enhanced by combining inhibiting concentrations of PMA with PKC inhibitors Go-6976 or Ro-318220, suggesting inhibition by PMA/DAG-driven non-PKC molecule(s).	Tetradecanoylphorbol Acetate	95-98	integrin subunit alpha M	Homo sapiens	34-39
1975240-4	1990	Treatment of U-937 cells with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in the presence of mAb to LFA-1 or ICAM-1 antigens yielded cells free from homotypic adhesions but differentiated as evidenced by their decreased proliferation and enhanced capacity for generation of superoxide anion.	Tetradecanoylphorbol Acetate	48-84	intercellular adhesion molecule 1	Homo sapiens	120-126
16480952-0	2006	Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cells.	Tetradecanoylphorbol Acetate	46-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-63
16480952-3	2006	To further understand how the mitogen-activated protein kinase signaling pathways regulate AP-1 activity and expression of c-Jun target genes, our strategy was based on the use of 12-o-tetradecanoylophorbol-13-acetate (TPA) and pharmacological reagents to induce or block c-Jun expression.	Tetradecanoylphorbol Acetate	219-222	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-128
16480952-4	2006	The mRNA and protein expression of these genes increased in response to TPA-induced c-Jun/AP-1 expression.	Tetradecanoylphorbol Acetate	72-75	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	84-89
2129414-6	1990	Tissue plasminogen activator activity (tPA) rose from 162 before to 1447 mIU/ml at 2 min.	Tetradecanoylphorbol Acetate	39-42	chromosome 20 open reading frame 181	Homo sapiens	0-28
16480952-4	2006	The mRNA and protein expression of these genes increased in response to TPA-induced c-Jun/AP-1 expression.	Tetradecanoylphorbol Acetate	72-75	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-94
16480952-7	2006	Taken together, these results suggested that differentiation-associated genes were regulated by TPA-induced c-Jun/AP-1 mainly via a PKC/JNK pathway in esophageal cancer cell line KYSE450.	Tetradecanoylphorbol Acetate	96-99	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	108-113
16480952-7	2006	Taken together, these results suggested that differentiation-associated genes were regulated by TPA-induced c-Jun/AP-1 mainly via a PKC/JNK pathway in esophageal cancer cell line KYSE450.	Tetradecanoylphorbol Acetate	96-99	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	114-118
2199463-6	1990	EGF and 12-0-tetradecanoyl phorbol-13-acetate (TPA) inhibited the Tg mRNA accumulation induced by TSH (and/or insulin).	Tetradecanoylphorbol Acetate	47-50	insulin	Canis lupus familiaris	110-117
16455237-4	2006	Conversely, PMA induced a marked increase of MT1-MMP and MMP-9.	Tetradecanoylphorbol Acetate	12-15	matrix metallopeptidase 9	Homo sapiens	57-62
2370555-0	1990	Induction of nerve growth factor gene expression by 12-O-tetradecanoyl phorbol 13-acetate.	Tetradecanoylphorbol Acetate	52-89	nerve growth factor	Mus musculus	13-32
16324695-2	2006	Preincubation with 1 microM of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) caused a small but significant decrease in isoprenaline-induced E(max), indicating activated PKC-mediated heterologous beta(2)-adrenoceptor desensitization.	Tetradecanoylphorbol Acetate	68-99	adrenoceptor beta 2	Bos taurus	225-245
2370555-3	1990	We investigated whether 12-O-tetradecanoyl phorbol 13-acetate (TPA), also a known stimulator of protein kinase C, regulates NGF gene expression.	Tetradecanoylphorbol Acetate	24-61	nerve growth factor	Mus musculus	124-127
16324695-2	2006	Preincubation with 1 microM of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) caused a small but significant decrease in isoprenaline-induced E(max), indicating activated PKC-mediated heterologous beta(2)-adrenoceptor desensitization.	Tetradecanoylphorbol Acetate	101-104	adrenoceptor beta 2	Bos taurus	225-245
14638691-4	2004	In the current study, comparative analysis of PKCalpha processing induced by the PKC agonists phorbol 12-myristate 13-acetate and bryostatin 1 in IEC-18 rat intestinal epithelial cells demonstrates that: (a) at least two pathways of PKCalpha down-regulation can co-exist within cells, and (b) a single PKC agonist can activate both pathways at the same time.	Tetradecanoylphorbol Acetate	94-125	protein kinase C, alpha	Rattus norvegicus	46-54
2370555-3	1990	We investigated whether 12-O-tetradecanoyl phorbol 13-acetate (TPA), also a known stimulator of protein kinase C, regulates NGF gene expression.	Tetradecanoylphorbol Acetate	63-66	nerve growth factor	Mus musculus	124-127
14638691-4	2004	In the current study, comparative analysis of PKCalpha processing induced by the PKC agonists phorbol 12-myristate 13-acetate and bryostatin 1 in IEC-18 rat intestinal epithelial cells demonstrates that: (a) at least two pathways of PKCalpha down-regulation can co-exist within cells, and (b) a single PKC agonist can activate both pathways at the same time.	Tetradecanoylphorbol Acetate	94-125	protein kinase C, alpha	Rattus norvegicus	46-49
2370555-4	1990	We show here that TPA stimulates NGF mRNA in mouse kidney and L929 fibroblasts but not in dispersed salivary cells.	Tetradecanoylphorbol Acetate	18-21	nerve growth factor	Mus musculus	33-36
14638691-4	2004	In the current study, comparative analysis of PKCalpha processing induced by the PKC agonists phorbol 12-myristate 13-acetate and bryostatin 1 in IEC-18 rat intestinal epithelial cells demonstrates that: (a) at least two pathways of PKCalpha down-regulation can co-exist within cells, and (b) a single PKC agonist can activate both pathways at the same time.	Tetradecanoylphorbol Acetate	94-125	protein kinase C, alpha	Rattus norvegicus	81-84
2370555-6	1990	The induction of NGF mRNA is inhibited by cycloheximide, NGF mRNA levels decrease to similar values after 4 h of incubation with actinomycin D alone or in combination with TPA.	Tetradecanoylphorbol Acetate	172-175	nerve growth factor	Mus musculus	17-20
16155104-6	2006	Phorbol 12-myristate 13-acetate (PMA) induced nuclear translocation of endogenous PKC alpha and Ad-wtPKC alpha concomitantly with an increase in nuclear TR alpha1 protein.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, alpha	Rattus norvegicus	82-91
2370555-6	1990	The induction of NGF mRNA is inhibited by cycloheximide, NGF mRNA levels decrease to similar values after 4 h of incubation with actinomycin D alone or in combination with TPA.	Tetradecanoylphorbol Acetate	172-175	nerve growth factor	Mus musculus	57-60
16155104-6	2006	Phorbol 12-myristate 13-acetate (PMA) induced nuclear translocation of endogenous PKC alpha and Ad-wtPKC alpha concomitantly with an increase in nuclear TR alpha1 protein.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, alpha	Rattus norvegicus	82-91
14977346-4	2004	In unstimulated and after stimulation with either N-formyl-methionyl-leucyl-phenylalanine or phorbol-12-myristate-13-acetate neutrophil surface expression of PSGL-1, L-selectin, CD11a and CD11b were measured by flow cytometry.	Tetradecanoylphorbol Acetate	93-124	L-selectin	Oryctolagus cuniculus	166-176
2194392-7	1990	When stimulated in vitro by anti-mu and TPA, (phorbol ester) tumor cells showed a decrease in CD21 and Slg and a stronger expression of CD25, T9, T10, and PCA1, with evidence of Ig secretion in four out of the seven cases studied.	Tetradecanoylphorbol Acetate	40-43	interferon stimulated exonuclease gene 20	Homo sapiens	136-140
14630988-7	2004	In addition, the percentages of T cells secreting IFN-gamma after in vitro stimulation with phorbol myristate acetate and ionomycin was significantly higher in infected fetuses [10% (5-25)] than in healthy fetuses [0.8% (0.6-1.2)] with IFN-gamma being mostly secreted by CD8(+) T cells and to a lesser extend by CD4(+) T cells.	Tetradecanoylphorbol Acetate	92-117	CD8a molecule	Homo sapiens	271-274
16847746-1	2006	The expression of CXCR4, a membrane protein which is involved in the entry of HIV-1, is down-modulated from the cell surface by Phorbol 12-myristate 13-acetate (PMA) and the Ca+ ionophore, Ionomycin.	Tetradecanoylphorbol Acetate	128-159	C-X-C motif chemokine receptor 4	Homo sapiens	18-23
16847746-1	2006	The expression of CXCR4, a membrane protein which is involved in the entry of HIV-1, is down-modulated from the cell surface by Phorbol 12-myristate 13-acetate (PMA) and the Ca+ ionophore, Ionomycin.	Tetradecanoylphorbol Acetate	161-164	C-X-C motif chemokine receptor 4	Homo sapiens	18-23
16847746-2	2006	Inducible co-stimulator (ICOS), which contributes to lymphocyte proliferation, is up-regulated by PMA/Ionomycin.	Tetradecanoylphorbol Acetate	98-101	inducible T cell costimulator	Homo sapiens	0-23
16847746-2	2006	Inducible co-stimulator (ICOS), which contributes to lymphocyte proliferation, is up-regulated by PMA/Ionomycin.	Tetradecanoylphorbol Acetate	98-101	inducible T cell costimulator	Homo sapiens	25-29
1695727-3	1990	Database searches have revealed no similarities between cMG1 and other genes, except that over a 67-amino acid region the cMG1 protein shows 72% identity to the product of the TIS11 gene, a TPA-induced sequence in Swiss 3T3 cells.	Tetradecanoylphorbol Acetate	190-193	zinc finger protein 36	Mus musculus	176-181
16847746-4	2006	In this report, we show that SNG interferes with both effects of PMA/Ionomycin, namely CXCR4 down-regulation and ICOS up-regulation.	Tetradecanoylphorbol Acetate	65-68	C-X-C motif chemokine receptor 4	Homo sapiens	87-92
16283633-6	2006	Injection of phorbolmyristate acetate (PMA), an activator of protein kinase C (PKC) that in turn upregulates OPG expression, also delayed eruption by 1 day.	Tetradecanoylphorbol Acetate	13-37	protein kinase C, alpha	Rattus norvegicus	79-82
15033023-5	2004	RESULTS: (1) The expressions of both JWA protein and Hsp70 were significantly up-regulated after K562 cells treated by TPA (100, 200 ng/ml) or adriamycin (4 x 10(-8) mol/L) 48 h, and followed by heat shock (42 degrees C, 2 h).	Tetradecanoylphorbol Acetate	119-122	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	37-40
15033023-5	2004	RESULTS: (1) The expressions of both JWA protein and Hsp70 were significantly up-regulated after K562 cells treated by TPA (100, 200 ng/ml) or adriamycin (4 x 10(-8) mol/L) 48 h, and followed by heat shock (42 degrees C, 2 h).	Tetradecanoylphorbol Acetate	119-122	heat shock protein family A (Hsp70) member 4	Homo sapiens	53-58
14570867-7	2004	Expression of ABCA1-GFP- and apoA-I-mediated lipid release were enhanced in parallel by phorbol 12-myristate 13-acetate (PMA) in 293/2c cells.	Tetradecanoylphorbol Acetate	88-119	ATP binding cassette subfamily A member 1	Homo sapiens	14-19
16283633-6	2006	Injection of phorbolmyristate acetate (PMA), an activator of protein kinase C (PKC) that in turn upregulates OPG expression, also delayed eruption by 1 day.	Tetradecanoylphorbol Acetate	39-42	protein kinase C, alpha	Rattus norvegicus	79-82
16283633-7	2006	PMA was only injected from Days 1-4 such that PKC-alpha would be increased and activated.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	46-55
1972160-5	1990	This costimulation cannot be readily accounted for by ICAM-1-mediated adhesion but is consistent with a role in signaling, which is observed in ICAM-1-mediated augmentation of activation induced by PMA/ionomycin.	Tetradecanoylphorbol Acetate	198-201	intercellular adhesion molecule 1	Homo sapiens	144-150
14570867-7	2004	Expression of ABCA1-GFP- and apoA-I-mediated lipid release were enhanced in parallel by phorbol 12-myristate 13-acetate (PMA) in 293/2c cells.	Tetradecanoylphorbol Acetate	121-124	ATP binding cassette subfamily A member 1	Homo sapiens	14-19
2334926-9	1990	Preincubation of HL-60 or K562 cells with 1 to 100 nM 12-O-tetradecanoylphorbol-13-acetate for 10 min prior to the addition of SRI 62-834 inhibited the rise in intracellular calcium in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	54-90	sorcin	Homo sapiens	127-130
14979936-4	2004	RA-PBMCs activated with phytohemagglutinin and phorbol 12-myristate 13-acetate showed an increased sensitivity to IL-12 and IL-18, but still the RA-PBMC response was lower.	Tetradecanoylphorbol Acetate	47-78	interleukin 18	Homo sapiens	124-129
16242794-6	2005	Phorbol myristate acetate (PMA), a protein kinase C (PKC) activator, completely prevented Ang II-stimulated eNOS protein expression at 8 h, whereas depletion of PKC by long-term treatment with PMA, induced eNOS protein expression.	Tetradecanoylphorbol Acetate	27-30	protein kinase C alpha	Bos taurus	53-56
16242794-6	2005	Phorbol myristate acetate (PMA), a protein kinase C (PKC) activator, completely prevented Ang II-stimulated eNOS protein expression at 8 h, whereas depletion of PKC by long-term treatment with PMA, induced eNOS protein expression.	Tetradecanoylphorbol Acetate	27-30	protein kinase C alpha	Bos taurus	161-164
16242794-6	2005	Phorbol myristate acetate (PMA), a protein kinase C (PKC) activator, completely prevented Ang II-stimulated eNOS protein expression at 8 h, whereas depletion of PKC by long-term treatment with PMA, induced eNOS protein expression.	Tetradecanoylphorbol Acetate	193-196	protein kinase C alpha	Bos taurus	161-164
15630183-8	2004	Up regulation of ICAM-1, VCAM-1 cyclooxygenase-2 (COX-2), KC and MIP-2 by TPA were markedly reduced by pre-treatment with extract of perilla (PE) or RA.	Tetradecanoylphorbol Acetate	74-77	intercellular adhesion molecule 1	Homo sapiens	17-23
2111343-6	1990	Thus, PMA treatment appears to have dissociated agonist-induced arachidonic acid liberation (index of phospholipase A2) from phosphoinositide hydrolysis (index of phospholipase C), suggesting that these two coupling processes can occur in a parallel and independent manner in mouse peritoneal macrophages.	Tetradecanoylphorbol Acetate	6-9	phospholipase A2, group IB, pancreas	Mus musculus	102-118
15981203-6	2005	The activities of cutaneous gamma-glutamyl transpeptidase (GGT) and glutathione-S-transferase P (GST-P), marker enzymes of tumorigenesis, were found to exhibit higher expression in AO or isolated sanguinarine/TPA treated groups when compared to control.	Tetradecanoylphorbol Acetate	209-212	inactive glutathione hydrolase 2	Homo sapiens	28-57
15981203-6	2005	The activities of cutaneous gamma-glutamyl transpeptidase (GGT) and glutathione-S-transferase P (GST-P), marker enzymes of tumorigenesis, were found to exhibit higher expression in AO or isolated sanguinarine/TPA treated groups when compared to control.	Tetradecanoylphorbol Acetate	209-212	inactive glutathione hydrolase 2	Homo sapiens	59-62
15010730-5	2004	RESULTS: A kinetic study in healthy controls showed that stimulation with phorbol 12-myristate 13-acetate and ionomycin significantly increased the frequencies of IL-10-producing CD3+, CD4+ and CD8+ cells.	Tetradecanoylphorbol Acetate	74-105	interleukin 10	Homo sapiens	163-168
2113601-4	1990	Upon treatment with TPA or Bryo, the steady-state levels of c-jun mRNA increased rapidly, reached a maximum at 0.5 or 1 hr, and then decreased in the B-CLL cells from all five patients analyzed; this reaction was augmented by the addition of A23187.	Tetradecanoylphorbol Acetate	20-23	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-65
15010730-5	2004	RESULTS: A kinetic study in healthy controls showed that stimulation with phorbol 12-myristate 13-acetate and ionomycin significantly increased the frequencies of IL-10-producing CD3+, CD4+ and CD8+ cells.	Tetradecanoylphorbol Acetate	74-105	CD8a molecule	Homo sapiens	194-197
16524842-12	2005	The expression of cyclin D1 and c-fos were detected only in the tumorous skin tissues of the TPA-treated group.	Tetradecanoylphorbol Acetate	93-96	cyclin D1	Mus musculus	18-27
2112749-5	1990	As previously shown in patients with AIDS, even in asymptomatic HIV-1-seropositive patients, CD8+DR+ cells from the same patient, compared to CD8+DR- lymphocytes, showed a substantial reduction in their ability to proliferate in vitro in response to different stimuli, such as mitogens (phytohemagglutinin and phorbol 12-myristate 13-acetate) and monoclonal antibodies directed against CD3, CD2, and CD28 molecules, and displayed a defective clonogenic potential.	Tetradecanoylphorbol Acetate	310-341	CD8a molecule	Homo sapiens	93-96
16183650-4	2005	The apoptotic effect of phorbol 12-myristate 13-acetate in LNCaP cells was impaired by inhibition or depletion of tumor necrosis factor alpha-converting enzyme, the enzyme responsible for tumor necrosis factor alpha (TNFalpha) shedding.	Tetradecanoylphorbol Acetate	24-55	ADAM metallopeptidase domain 17	Homo sapiens	114-159
15763930-7	2004	Injection of a PKC activator, phorbol 12-myristate 13-acetate (PMA), at late postnatal days, slightly accelerated first mandibular molar eruption.	Tetradecanoylphorbol Acetate	30-61	protein kinase C, alpha	Rattus norvegicus	15-18
15763930-7	2004	Injection of a PKC activator, phorbol 12-myristate 13-acetate (PMA), at late postnatal days, slightly accelerated first mandibular molar eruption.	Tetradecanoylphorbol Acetate	63-66	protein kinase C, alpha	Rattus norvegicus	15-18
2112750-1	1990	We show that the stimulation of human immunodeficiency virus (HIV) brought about by tumor necrosis factor alpha and phorbol 12-myristate 13-acetate can be inhibited by adding N-acetyl-L-cysteine (NAC).	Tetradecanoylphorbol Acetate	116-147	X-linked Kx blood group	Homo sapiens	196-199
16125466-3	2005	The proportion of CD4+ and CD8+ T cells that produced IFN-gamma and IL-4 after stimulation with PMA (Phorbol 12-myristate 13-acetate) and ionomycin was significantly reduced in VL patients compared to sub-clinical and asymptomatic infections or healthy controls.	Tetradecanoylphorbol Acetate	96-99	CD8a molecule	Homo sapiens	27-30
16125466-3	2005	The proportion of CD4+ and CD8+ T cells that produced IFN-gamma and IL-4 after stimulation with PMA (Phorbol 12-myristate 13-acetate) and ionomycin was significantly reduced in VL patients compared to sub-clinical and asymptomatic infections or healthy controls.	Tetradecanoylphorbol Acetate	101-132	CD8a molecule	Homo sapiens	27-30
15136882-5	2004	Treatment of NPVSM with 10 nM 4-beta phorbol myristate acetate (PMA), a PKC activator, induced translocation of PKCalpha, and PKCdelta from the soluble to the particulate fraction, while exposure to 10 nM endothelin-1 (ET-1), a potent vasoconstrictor and mitogenic substance, caused translocation of PKCdelta and PKCiota from the soluble to the particulate fraction.	Tetradecanoylphorbol Acetate	64-67	protein kinase C, alpha	Rattus norvegicus	112-120
2159816-8	1990	Unlike in other cells tested, the jun and c-fos transcription factor mRNAs showed a prolonged biphasic induction response in K562 cells during TPA treatment.	Tetradecanoylphorbol Acetate	143-146	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-47
14709397-8	2004	In addition, both neutrophil adhesion and ICAM-1 expression which were increased by a MAP kinase activator, anisomycin (1 microM), or a PKC activator, phorbol 12-myristate 13-acetate (10 nM) were also attenuated by gliclazide.	Tetradecanoylphorbol Acetate	151-182	intercellular adhesion molecule 1	Homo sapiens	42-48
16323285-8	2005	Conversely, protein levels of manganese superoxide dismutase and the matrix metalloproteinases MMP-1 and MMP-9 were progressively increased in TPA-treated asPARP TUR cells, respectively.	Tetradecanoylphorbol Acetate	143-146	matrix metallopeptidase 9	Homo sapiens	105-110
2159816-9	1990	This response was associated with enhanced activity of a transfected recombinant reporter plasmid containing binding sites for the jun/fos transcription factor complex (AP-1) similar to the TPA-responsive element (TRE) sequence we found in the EPA/TIMP gene promoter.	Tetradecanoylphorbol Acetate	190-193	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	135-138
2110512-2	1990	PAMBCu inhibited TPA-caused epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. skin inflammation.	Tetradecanoylphorbol Acetate	17-20	ornithine decarboxylase, structural 1	Mus musculus	38-61
16265694-5	2005	Intracellular staining of interleukin 10 (IL-10) was performed after stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	86-89	interleukin 10	Homo sapiens	26-40
16265694-5	2005	Intracellular staining of interleukin 10 (IL-10) was performed after stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	86-89	interleukin 10	Homo sapiens	42-47
16265694-8	2005	PD-1-positive SS salivary lymphocytes expressed IL-10 intracellularly upon PMA/ionomycin stimulation.	Tetradecanoylphorbol Acetate	75-78	interleukin 10	Homo sapiens	48-53
15976015-5	2005	injections of TPA strongly inhibited tumor growth, increased the percentage of caspase-3-positive cells, and decreased the ratio of mitotic cells to caspase-3-positive cells in the tumors.	Tetradecanoylphorbol Acetate	14-17	caspase 3	Mus musculus	79-88
12879265-6	2004	Specific protein kinase C activator phorbol myristate acetate reduced transcription and secretion of IL-18 in RA SF and OA SF.	Tetradecanoylphorbol Acetate	36-61	interleukin 18	Homo sapiens	101-106
2110512-2	1990	PAMBCu inhibited TPA-caused epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. skin inflammation.	Tetradecanoylphorbol Acetate	17-20	ornithine decarboxylase, structural 1	Mus musculus	63-66
15976015-5	2005	injections of TPA strongly inhibited tumor growth, increased the percentage of caspase-3-positive cells, and decreased the ratio of mitotic cells to caspase-3-positive cells in the tumors.	Tetradecanoylphorbol Acetate	14-17	caspase 3	Mus musculus	149-158
2138520-6	1990	A tumor-promoting phorbol ester, TPA, rendered TNF-sensitive and -insensitive EL4 cells resistant to M phi-mediated lysis.	Tetradecanoylphorbol Acetate	33-36	epilepsy 4	Mus musculus	78-81
14644357-9	2003	Furthermore, CHL, hemin and TBAP decreased myeloperoxidase (MPO) activity and H(2)O(2) formation as well as epidermal ornithine decarboxylase (ODC) activity in mouse skin treated with TPA.	Tetradecanoylphorbol Acetate	184-187	ornithine decarboxylase, structural 1	Mus musculus	118-141
16228063-0	2005	Mechanism of CD11b down-regulation from phorbol myristate acetate stimulated polymorphonuclear neutrophils.	Tetradecanoylphorbol Acetate	40-65	integrin subunit alpha M	Homo sapiens	13-18
2157661-3	1990	After 24 h there was a significant (P less than 0.001) increase in MPO levels in the PMA-treated colons compared to ethanol control.	Tetradecanoylphorbol Acetate	85-88	myeloperoxidase	Oryctolagus cuniculus	67-70
16228063-1	2005	OBJECTIVE: To investigate the mechanism of CD11b down-regulation in phorbol myristate acetate (PMA) stimulated polymorphonuclear leukocytes (PMN).	Tetradecanoylphorbol Acetate	68-93	integrin subunit alpha M	Homo sapiens	43-48
16228063-1	2005	OBJECTIVE: To investigate the mechanism of CD11b down-regulation in phorbol myristate acetate (PMA) stimulated polymorphonuclear leukocytes (PMN).	Tetradecanoylphorbol Acetate	95-98	integrin subunit alpha M	Homo sapiens	43-48
14644357-9	2003	Furthermore, CHL, hemin and TBAP decreased myeloperoxidase (MPO) activity and H(2)O(2) formation as well as epidermal ornithine decarboxylase (ODC) activity in mouse skin treated with TPA.	Tetradecanoylphorbol Acetate	184-187	ornithine decarboxylase, structural 1	Mus musculus	143-146
14654785-6	2003	Previously, tandem AP1 sites in the promoter were reported to be important for the serum and TPA inducibility of the vimentin gene.	Tetradecanoylphorbol Acetate	93-96	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	19-22
16156860-3	2005	For this purpose, Evi1 was conditionally expressed in human erythroleukaemia cells (HEL) that progress along the megakaryocyte lineage in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	154-190	MDS1 and EVI1 complex locus	Homo sapiens	18-22
2320002-4	1990	This protein, HB16, displays structural similarity to CREB and to c-Jun and c-Fos, which bind the related 12-O-tetradecanoylphorbol-13-acetate response element (TRE).	Tetradecanoylphorbol Acetate	106-142	activating transcription factor 2	Homo sapiens	14-18
16156860-3	2005	For this purpose, Evi1 was conditionally expressed in human erythroleukaemia cells (HEL) that progress along the megakaryocyte lineage in the presence of 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	192-195	MDS1 and EVI1 complex locus	Homo sapiens	18-22
16156860-8	2005	Sustained CDK2 catalytic activity, typically associated with megakaryocyte endomitosis, was dramatically decreased in TPA-stimulated Evi1-expressing HEL cells because of significantly reduced levels of cyclin A.	Tetradecanoylphorbol Acetate	118-121	MDS1 and EVI1 complex locus	Homo sapiens	133-137
16009334-5	2005	We show that the pp32-retinoblastoma protein complex is modulated during TPA-induced K562 differentiation.	Tetradecanoylphorbol Acetate	73-76	acidic nuclear phosphoprotein 32 family member A	Homo sapiens	17-21
14623285-0	2003	The synergistic activation of Raf-1 kinase by phorbol myristate acetate and hydrogen peroxide in NIH3T3 cells.	Tetradecanoylphorbol Acetate	46-71	v-raf-leukemia viral oncogene 1	Mus musculus	30-35
14623285-1	2003	We have previously demonstrated that a 33kDa C-terminal fragment of c-Raf-1 underwent a mobility shift in response to hydrogen peroxide (H(2)O(2)) and phorbol myristate acetate (PMA), respectively.	Tetradecanoylphorbol Acetate	151-176	v-raf-leukemia viral oncogene 1	Mus musculus	68-73
14623285-1	2003	We have previously demonstrated that a 33kDa C-terminal fragment of c-Raf-1 underwent a mobility shift in response to hydrogen peroxide (H(2)O(2)) and phorbol myristate acetate (PMA), respectively.	Tetradecanoylphorbol Acetate	178-181	v-raf-leukemia viral oncogene 1	Mus musculus	68-73
14623285-4	2003	Interestingly, H(2)O(2) produced synergistic increase of PMA-stimulated Raf-1 kinase activation after simultaneous treatment of PMA and H(2)O(2).	Tetradecanoylphorbol Acetate	57-60	v-raf-leukemia viral oncogene 1	Mus musculus	72-77
14623285-4	2003	Interestingly, H(2)O(2) produced synergistic increase of PMA-stimulated Raf-1 kinase activation after simultaneous treatment of PMA and H(2)O(2).	Tetradecanoylphorbol Acetate	128-131	v-raf-leukemia viral oncogene 1	Mus musculus	72-77
14623285-6	2003	Taken together, our data suggest that the synergistic activation of Raf-1 kinase in response to PMA and H(2)O(2) occurs via mechanisms that involve an interaction of Raf-1 kinase and PKC-epsilon, along with a transient phosphorylation of both Raf-1 kinase and PKC.	Tetradecanoylphorbol Acetate	96-99	v-raf-leukemia viral oncogene 1	Mus musculus	68-73
2320002-4	1990	This protein, HB16, displays structural similarity to CREB and to c-Jun and c-Fos, which bind the related 12-O-tetradecanoylphorbol-13-acetate response element (TRE).	Tetradecanoylphorbol Acetate	106-142	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-71
14623285-6	2003	Taken together, our data suggest that the synergistic activation of Raf-1 kinase in response to PMA and H(2)O(2) occurs via mechanisms that involve an interaction of Raf-1 kinase and PKC-epsilon, along with a transient phosphorylation of both Raf-1 kinase and PKC.	Tetradecanoylphorbol Acetate	96-99	v-raf-leukemia viral oncogene 1	Mus musculus	166-171
2320002-4	1990	This protein, HB16, displays structural similarity to CREB and to c-Jun and c-Fos, which bind the related 12-O-tetradecanoylphorbol-13-acetate response element (TRE).	Tetradecanoylphorbol Acetate	106-142	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-81
14623285-6	2003	Taken together, our data suggest that the synergistic activation of Raf-1 kinase in response to PMA and H(2)O(2) occurs via mechanisms that involve an interaction of Raf-1 kinase and PKC-epsilon, along with a transient phosphorylation of both Raf-1 kinase and PKC.	Tetradecanoylphorbol Acetate	96-99	v-raf-leukemia viral oncogene 1	Mus musculus	166-171
16098040-5	2005	Elevated extracellular calcium and acute 12-O-tetradecanoylphorbol-13-acetate (TPA) treatments induced differentiation and triggered a downmodulation of PKD levels, autophosphorylation at serine 916, and activity.	Tetradecanoylphorbol Acetate	41-77	protein kinase D1	Mus musculus	153-156
16098040-5	2005	Elevated extracellular calcium and acute 12-O-tetradecanoylphorbol-13-acetate (TPA) treatments induced differentiation and triggered a downmodulation of PKD levels, autophosphorylation at serine 916, and activity.	Tetradecanoylphorbol Acetate	79-82	protein kinase D1	Mus musculus	153-156
16098040-6	2005	Chronic TPA treatment stimulated proliferation and resulted in a recovery of PKD levels, autophosphorylation, and activity.	Tetradecanoylphorbol Acetate	8-11	protein kinase D1	Mus musculus	77-80
1690514-3	1990	Peak effects on c-fos mRNA occurred between 15 and 30 min and were completely gone after 2 h. The elevation in c-fos mRNA was, in part, dependent on protein kinase C, since phorbol myristate acetate (PMA) also elevated c-fos mRNA and further increased c-fos mRNA expression by endothelin, but the effects were not additive.	Tetradecanoylphorbol Acetate	173-198	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-21
15972968-3	2005	Here, we demonstrate enhanced expression of the small Ras-related GTPase Rab11a after short-term TPA treatment of mouse back skin.	Tetradecanoylphorbol Acetate	97-100	RAB11A, member RAS oncogene family	Mus musculus	73-79
1690514-3	1990	Peak effects on c-fos mRNA occurred between 15 and 30 min and were completely gone after 2 h. The elevation in c-fos mRNA was, in part, dependent on protein kinase C, since phorbol myristate acetate (PMA) also elevated c-fos mRNA and further increased c-fos mRNA expression by endothelin, but the effects were not additive.	Tetradecanoylphorbol Acetate	173-198	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	111-116
15972968-4	2005	Expression of Rab11a in vivo and in vitro critically depended on c-Fos, because TPA application to the back skin of c-Fos-deficient mice and to mouse embryonic fibroblasts did not induce Rab11a mRNA or protein expression.	Tetradecanoylphorbol Acetate	80-83	RAB11A, member RAS oncogene family	Mus musculus	14-20
12960151-9	2003	Furthermore, we detected the 2.8-kb PDGF-B mRNA in erythroleukemia K562 cells upon 12-O-tetradecanoylphorbol-13-acetate-induced differentiation.	Tetradecanoylphorbol Acetate	83-119	platelet derived growth factor subunit B	Homo sapiens	36-42
15972968-5	2005	Moreover, dexamethasone, which is a potent inhibitor of AP-1-mediated transactivation that exhibits anti-inflammatory and anti-tumor promoting activities, inhibited TPA-induced expression of Rab11a.	Tetradecanoylphorbol Acetate	165-168	RAB11A, member RAS oncogene family	Mus musculus	191-197
1690514-3	1990	Peak effects on c-fos mRNA occurred between 15 and 30 min and were completely gone after 2 h. The elevation in c-fos mRNA was, in part, dependent on protein kinase C, since phorbol myristate acetate (PMA) also elevated c-fos mRNA and further increased c-fos mRNA expression by endothelin, but the effects were not additive.	Tetradecanoylphorbol Acetate	173-198	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	111-116
15972968-6	2005	Within the Rab11a gene promoter, we identified a functional AP-1 binding element that exhibited elevated c-Fos binding activity after TPA treatment of keratinocytes.	Tetradecanoylphorbol Acetate	134-137	RAB11A, member RAS oncogene family	Mus musculus	11-17
1690514-3	1990	Peak effects on c-fos mRNA occurred between 15 and 30 min and were completely gone after 2 h. The elevation in c-fos mRNA was, in part, dependent on protein kinase C, since phorbol myristate acetate (PMA) also elevated c-fos mRNA and further increased c-fos mRNA expression by endothelin, but the effects were not additive.	Tetradecanoylphorbol Acetate	173-198	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	111-116
15806162-11	2005	RNAi-mediated knockdown of endogenous SRF, ELK1 and c-JUN protein expression significantly reduced TPA-stimulated FRA-1 promoter activity.	Tetradecanoylphorbol Acetate	99-102	serum response factor	Homo sapiens	38-41
14627504-4	2003	RESULTS: MMP-9 activity in U937 cells increased significantly after exposed to PMA at 10 nmol/L for 24 h without FCS (P&lt;0.01).	Tetradecanoylphorbol Acetate	79-82	matrix metallopeptidase 9	Homo sapiens	9-14
15806162-11	2005	RNAi-mediated knockdown of endogenous SRF, ELK1 and c-JUN protein expression significantly reduced TPA-stimulated FRA-1 promoter activity.	Tetradecanoylphorbol Acetate	99-102	ETS transcription factor ELK1	Homo sapiens	43-47
14627504-6	2003	Western blot and RT-PCR experiments displayed that MMP-9 protein (P&lt;0.01) and mRNA expression (P&lt;0.01) increased significantly in PMA-treated U937 cells.	Tetradecanoylphorbol Acetate	136-139	matrix metallopeptidase 9	Homo sapiens	51-56
1690514-3	1990	Peak effects on c-fos mRNA occurred between 15 and 30 min and were completely gone after 2 h. The elevation in c-fos mRNA was, in part, dependent on protein kinase C, since phorbol myristate acetate (PMA) also elevated c-fos mRNA and further increased c-fos mRNA expression by endothelin, but the effects were not additive.	Tetradecanoylphorbol Acetate	200-203	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-21
15806162-11	2005	RNAi-mediated knockdown of endogenous SRF, ELK1 and c-JUN protein expression significantly reduced TPA-stimulated FRA-1 promoter activity.	Tetradecanoylphorbol Acetate	99-102	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-57
1690514-3	1990	Peak effects on c-fos mRNA occurred between 15 and 30 min and were completely gone after 2 h. The elevation in c-fos mRNA was, in part, dependent on protein kinase C, since phorbol myristate acetate (PMA) also elevated c-fos mRNA and further increased c-fos mRNA expression by endothelin, but the effects were not additive.	Tetradecanoylphorbol Acetate	200-203	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	111-116
1690514-3	1990	Peak effects on c-fos mRNA occurred between 15 and 30 min and were completely gone after 2 h. The elevation in c-fos mRNA was, in part, dependent on protein kinase C, since phorbol myristate acetate (PMA) also elevated c-fos mRNA and further increased c-fos mRNA expression by endothelin, but the effects were not additive.	Tetradecanoylphorbol Acetate	200-203	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	111-116
14555991-5	2003	In K562 cells, Phorbol 12-myristate 13-acetate activates Erk1/2 and consequently increases Bim-EL phosphorylation and degradation by the proteasome, resulting in cell survival, while the Bcr-Abl inhibitor imatinib abrogates Bim-EL phosphorylation and degradation and induces caspase activation and apoptosis.	Tetradecanoylphorbol Acetate	15-46	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	187-194
2105842-8	1990	VL30 and MT mRNA levels were not found to be elevated in epidermal tumors whereas the mRNA level corresponding to glyceraldehyde-3-phosphate dehydrogenase was elevated in tumors and induced by TPA with time-kinetics that correlate with a TPA-induced hyperproliferation.	Tetradecanoylphorbol Acetate	193-196	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	114-154
15741214-7	2005	Activation (phorbol 12-myristate 13-acetate [PMA]/ionomycin) of normal T and B lymphocytes induced weak fibromodulin gene expression, but not to the extent seen in freshly isolated B-CLL cells.	Tetradecanoylphorbol Acetate	12-43	fibromodulin	Homo sapiens	104-116
15741214-7	2005	Activation (phorbol 12-myristate 13-acetate [PMA]/ionomycin) of normal T and B lymphocytes induced weak fibromodulin gene expression, but not to the extent seen in freshly isolated B-CLL cells.	Tetradecanoylphorbol Acetate	45-48	fibromodulin	Homo sapiens	104-116
12950238-3	2003	In this study, the intracellular interleukin-4 and interferon-gamma production in CD4+ T-lymphocytes activated by phorbol 12-myristate 13-acetate and ionomycin was assessed via flow cytometry in order to determine the clinical significance of the Th1/Th2 ratio in 42 patients with ITP.	Tetradecanoylphorbol Acetate	114-145	negative elongation factor complex member C/D	Homo sapiens	247-250
2105842-8	1990	VL30 and MT mRNA levels were not found to be elevated in epidermal tumors whereas the mRNA level corresponding to glyceraldehyde-3-phosphate dehydrogenase was elevated in tumors and induced by TPA with time-kinetics that correlate with a TPA-induced hyperproliferation.	Tetradecanoylphorbol Acetate	238-241	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	114-154
15821757-7	2005	At 1 microM, both agents inhibited PMA-induced PKC activity in ARVM.	Tetradecanoylphorbol Acetate	35-38	protein kinase C, alpha	Rattus norvegicus	47-50
2154599-6	1990	In addition, the Zta protein, which possesses a similar basic domain to the conserved DNA-binding region of the c-Fos, c-Jun, GCN4, and CREB protein family, proved to bind directly to the consensus AP-1 site in the collagenase 12-O-tetradecanoylphorbol-13-acetate response element.	Tetradecanoylphorbol Acetate	227-263	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	112-117
2154599-6	1990	In addition, the Zta protein, which possesses a similar basic domain to the conserved DNA-binding region of the c-Fos, c-Jun, GCN4, and CREB protein family, proved to bind directly to the consensus AP-1 site in the collagenase 12-O-tetradecanoylphorbol-13-acetate response element.	Tetradecanoylphorbol Acetate	227-263	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	119-124
15760920-3	2005	They mediated both the phorbol myristate acetate (PMA) downregulation of DMBT1 expression and the initiation of cell differentiation, which was measured by cell cycle withdrawal and the induction of the tissue-specific marker trefoil factor 1 (TFF1).	Tetradecanoylphorbol Acetate	23-48	deleted in malignant brain tumors 1	Homo sapiens	73-78
2154599-6	1990	In addition, the Zta protein, which possesses a similar basic domain to the conserved DNA-binding region of the c-Fos, c-Jun, GCN4, and CREB protein family, proved to bind directly to the consensus AP-1 site in the collagenase 12-O-tetradecanoylphorbol-13-acetate response element.	Tetradecanoylphorbol Acetate	227-263	cAMP responsive element binding protein 1	Homo sapiens	136-140
15760920-3	2005	They mediated both the phorbol myristate acetate (PMA) downregulation of DMBT1 expression and the initiation of cell differentiation, which was measured by cell cycle withdrawal and the induction of the tissue-specific marker trefoil factor 1 (TFF1).	Tetradecanoylphorbol Acetate	50-53	deleted in malignant brain tumors 1	Homo sapiens	73-78
2154599-6	1990	In addition, the Zta protein, which possesses a similar basic domain to the conserved DNA-binding region of the c-Fos, c-Jun, GCN4, and CREB protein family, proved to bind directly to the consensus AP-1 site in the collagenase 12-O-tetradecanoylphorbol-13-acetate response element.	Tetradecanoylphorbol Acetate	227-263	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	198-202
2154599-8	1990	Cellular AP-1 binding activity proved to be low in latently EBV-infected Raji cells but was induced (together with the Zta protein) after activation of the lytic cycle with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	173-209	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	9-13
12860017-5	2003	Besides the staurosporines, also 12-O-tetradecanoyl phorbol acetate (TPA) and tumor necrosis factor-alpha (TNFalpha) strongly increased the IL-8 and MCP-1 secretion of NB-4 cells.	Tetradecanoylphorbol Acetate	33-67	chemokine (C-C motif) ligand 2	Mus musculus	149-154
16006663-6	2005	Interestingly, PMA (phorbol 12-myristate 13-acetate)-induced sAbetaPP production was maintained under the stress conditions used, suggesting that potential non-amyloidogenic AbetaPP processing can still be favoured.	Tetradecanoylphorbol Acetate	15-18	amyloid beta precursor protein	Rattus norvegicus	62-69
12860017-5	2003	Besides the staurosporines, also 12-O-tetradecanoyl phorbol acetate (TPA) and tumor necrosis factor-alpha (TNFalpha) strongly increased the IL-8 and MCP-1 secretion of NB-4 cells.	Tetradecanoylphorbol Acetate	69-72	chemokine (C-C motif) ligand 2	Mus musculus	149-154
2154605-6	1990	A distinct TPA-responsive element (ZII) is located near the TATA box and shares homology with the AP-1-binding site in the c-jun promoter.	Tetradecanoylphorbol Acetate	11-14	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-128
16006663-6	2005	Interestingly, PMA (phorbol 12-myristate 13-acetate)-induced sAbetaPP production was maintained under the stress conditions used, suggesting that potential non-amyloidogenic AbetaPP processing can still be favoured.	Tetradecanoylphorbol Acetate	20-51	amyloid beta precursor protein	Rattus norvegicus	62-69
16006663-7	2005	This is of potential therapeutic interest, since it indicates that even under adverse stress conditions drugs such as PMA can affect AbetaPP processing, leading to increased sAbetaPP production and a concomitant reduction in Abeta production.	Tetradecanoylphorbol Acetate	118-121	amyloid beta precursor protein	Rattus norvegicus	133-140
2138330-5	1990	Functional evidence for a specific association between CD16 and zeta NK in intact cells was obtained by demonstrating a coordinate down-modulation of both of these molecules induced by either phorbol 12-myristate 13-acetate or monoclonal antibodies reactive with CD16.	Tetradecanoylphorbol Acetate	192-223	Fc gamma receptor IIIa	Homo sapiens	55-59
16006663-7	2005	This is of potential therapeutic interest, since it indicates that even under adverse stress conditions drugs such as PMA can affect AbetaPP processing, leading to increased sAbetaPP production and a concomitant reduction in Abeta production.	Tetradecanoylphorbol Acetate	118-121	amyloid beta precursor protein	Rattus norvegicus	133-138
15911072-9	2005	Furthermore, the activation of NPR-C receptor by C-ANP(4-23) and CNP inhibits the mitogen-activated protein kinase activity stimulated by endothelin-3, platelet-derived growth factor, phorbol-12 myristate 13-acetate, suggesting that NPR-C receptor might also be coupled to other signal transduction system or that there may be an interaction of the NPR-C receptor and some other signaling pathways.	Tetradecanoylphorbol Acetate	184-215	natriuretic peptide C	Homo sapiens	65-68
12898704-3	2003	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) induced MMP-9 but not MMP-2 secretion as measured by gelatin zymography.	Tetradecanoylphorbol Acetate	37-68	matrix metallopeptidase 9	Rattus norvegicus	83-88
12898704-3	2003	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) induced MMP-9 but not MMP-2 secretion as measured by gelatin zymography.	Tetradecanoylphorbol Acetate	70-73	matrix metallopeptidase 9	Rattus norvegicus	83-88
1689299-4	1990	In contrast, factors that inhibit endothelial cell proliferation such as phorbol myristate acetate and the cytokines interleukin-1, interleukin-6, and tumor necrosis factor-alpha increase both PDGF A-chain and B-chain mRNA levels.	Tetradecanoylphorbol Acetate	73-98	platelet derived growth factor subunit A	Homo sapiens	193-205
12819195-5	2003	Additionally, TPA treatment alters the activity of cytoplasmic complexes that bind AREs, including complexes containing the ARE-specific, mRNA-destabilizing factor, AUF1.	Tetradecanoylphorbol Acetate	14-17	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	165-169
12819195-6	2003	Analyses of AUF1 from control and TPA-treated cells indicated that post-translational modifications of the major cytoplasmic isoform, p40AUF1, are altered concomitant with changes in RNA binding activity and stabilization of ARE-containing mRNAs.	Tetradecanoylphorbol Acetate	34-37	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	12-16
15855058-8	2005	Inhibition of PKCalpha in isolated TII cells by long-time incubation with PMA inhibited PKCalpha and Prx-1 but not Prx-6.	Tetradecanoylphorbol Acetate	74-77	protein kinase C, alpha	Rattus norvegicus	14-22
15855058-8	2005	Inhibition of PKCalpha in isolated TII cells by long-time incubation with PMA inhibited PKCalpha and Prx-1 but not Prx-6.	Tetradecanoylphorbol Acetate	74-77	protein kinase C, alpha	Rattus norvegicus	88-96
15855058-8	2005	Inhibition of PKCalpha in isolated TII cells by long-time incubation with PMA inhibited PKCalpha and Prx-1 but not Prx-6.	Tetradecanoylphorbol Acetate	74-77	periaxin	Rattus norvegicus	101-104
15757899-2	2005	In the current study, the regulation of NAG-1 expression in LNCaP human prostate carcinoma cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) was examined.	Tetradecanoylphorbol Acetate	100-136	growth differentiation factor 15	Homo sapiens	40-45
15757899-2	2005	In the current study, the regulation of NAG-1 expression in LNCaP human prostate carcinoma cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) was examined.	Tetradecanoylphorbol Acetate	138-141	growth differentiation factor 15	Homo sapiens	40-45
15757899-3	2005	TPA treatment increased NAG-1 protein and mRNA levels in a time- and concentration-dependent manner as well as NF-kappa B binding/transcriptional activity in LNCaP cells.	Tetradecanoylphorbol Acetate	0-3	growth differentiation factor 15	Homo sapiens	24-29
15757899-4	2005	Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.	Tetradecanoylphorbol Acetate	63-66	growth differentiation factor 15	Homo sapiens	87-92
12881422-3	2003	However, the phorbol ester (TPA) and EGF-induced phosphorylation of Ser63 and Ser73 is mediated by ERK1/ERK2, as well as JNK1/JNK2, in fibroblasts from wild-type mice and by ERK1/ERK2 alone in fibroblasts from JNK-deficient mice.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 8	Mus musculus	121-125
1689353-5	1990	RAP potentiated the effect of CsA on proliferation and IL-2R expression in T cells stimulated with ionomycin + PMA.	Tetradecanoylphorbol Acetate	111-114	interleukin 2 receptor, alpha chain	Mus musculus	55-60
15862172-11	2005	Following exposure of RPE cells to PMA for 24 hr, PKC-delta was significantly down regulated, whereas PKC-alpha, -beta, -epsilon and -zeta remained unchanged.	Tetradecanoylphorbol Acetate	35-38	protein kinase C, alpha	Rattus norvegicus	102-138
2306238-4	1990	10(-7)M 12-O-tetradecanoyl phorbol -13-acetate (TPA) increased aFGF mRNA expression in both proliferating and differentiated satellite cells.	Tetradecanoylphorbol Acetate	8-46	fibroblast growth factor 1	Rattus norvegicus	63-67
15728660-7	2005	Simvastatin reduced TPA- and PDGF/IL-1-induced MMP-9 secretion and mRNA levels, effects reversed by geranylgeranyl pyrophosphate and mimicked by inhibiting Rho geranylgeranylation or Rho-kinase (ROCK).	Tetradecanoylphorbol Acetate	20-23	matrix metallopeptidase 9	Homo sapiens	47-52
12881422-3	2003	However, the phorbol ester (TPA) and EGF-induced phosphorylation of Ser63 and Ser73 is mediated by ERK1/ERK2, as well as JNK1/JNK2, in fibroblasts from wild-type mice and by ERK1/ERK2 alone in fibroblasts from JNK-deficient mice.	Tetradecanoylphorbol Acetate	28-31	mitogen-activated protein kinase 8	Mus musculus	121-124
12818356-8	2003	TPA and Thapsigargin were capable of decreasing the level of CD4 molecules on the cell surface, probably due to the loss of these molecules.	Tetradecanoylphorbol Acetate	0-3	CD4 antigen	Mus musculus	61-64
2306238-4	1990	10(-7)M 12-O-tetradecanoyl phorbol -13-acetate (TPA) increased aFGF mRNA expression in both proliferating and differentiated satellite cells.	Tetradecanoylphorbol Acetate	48-51	fibroblast growth factor 1	Rattus norvegicus	63-67
2105157-2	1990	Apigenin was a potent inhibitor of epidermal ornithine decarboxylase induction by TPA in a dose-dependent manner from 1 to 20 mumol.	Tetradecanoylphorbol Acetate	82-85	ornithine decarboxylase, structural 1	Mus musculus	45-68
12810552-7	2003	Surprisingly, the activation function (AF)-1-dependent transactivation triggered by epithelial growth factor and phorbol-12-myristate-13-acetate is also abolished in ERDeltaE7 despite AF1 integrity, suggesting a cross-talk between AF1 and AF2 regions of the receptor.	Tetradecanoylphorbol Acetate	113-144	interferon gamma receptor 2	Homo sapiens	231-234
12810623-2	2003	TPA treatment induced epidermal ornithine decarboxylase (ODC) activity and putrescine levels approximately 3-4-fold more in PKC epsilon transgenic mice than their wild-type littermates.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	32-55
12810623-2	2003	TPA treatment induced epidermal ornithine decarboxylase (ODC) activity and putrescine levels approximately 3-4-fold more in PKC epsilon transgenic mice than their wild-type littermates.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	57-60
12810623-6	2003	These results indicate that TPA-induced ODC activity and the resultant accumulation of putrescine in PKC epsilon transgenic mice are linked to growth and maintenance of hair follicles, and the development of mSCC.	Tetradecanoylphorbol Acetate	28-31	ornithine decarboxylase, structural 1	Mus musculus	40-43
15752728-4	2005	To figure out the effect of PLD on synapsin I expression, we treated the neural stem cells with phorbol myristate acetate (PMA) to stimulate PLD activity.	Tetradecanoylphorbol Acetate	96-121	synapsin I	Rattus norvegicus	35-45
15737651-5	2005	A luciferase reporter assay demonstrated that upregulation of TTMP by TPA is triggered at the promoter level.	Tetradecanoylphorbol Acetate	70-73	chromosome 3 open reading frame 52	Homo sapiens	62-66
1690135-0	1990	The role of CD44, CD45, CD45RO, CD46 and CD55 as potential anti-adhesion molecules involved in the binding of human tonsillar T cells to phorbol 12-myristate 13-acetate-differentiated U-937 cells.	Tetradecanoylphorbol Acetate	137-168	CD55 molecule (Cromer blood group)	Homo sapiens	41-45
15794745-4	2005	We found that phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC), decreased the level of autophosphorylated PKR in a dose- and time-dependent manner in IFN-treated mouse fibroblast cells.	Tetradecanoylphorbol Acetate	14-45	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	141-144
15794745-4	2005	We found that phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC), decreased the level of autophosphorylated PKR in a dose- and time-dependent manner in IFN-treated mouse fibroblast cells.	Tetradecanoylphorbol Acetate	47-50	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	141-144
12810681-0	2003	Dykellic acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor kappa B transcriptional activity.	Tetradecanoylphorbol Acetate	23-48	matrix metallopeptidase 9	Homo sapiens	57-83
12810681-2	2003	Expression of MMPs is regulated by cytokines and signal transduction pathways, including those activated by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	108-133	matrix metallopeptidase 9	Homo sapiens	14-18
12810681-3	2003	We found that dykellic acid, a fungal metabolite, significantly inhibits the phorbol myristate acetate-induced increase in MMP-9 expression and activity.	Tetradecanoylphorbol Acetate	77-102	matrix metallopeptidase 9	Homo sapiens	123-128
2158073-1	1990	The nuclear oncoproteins fos and jun are associated as a heterodimer which binds to TPA (PMA or TPA: phorbol 12-myristate 13-acetate)- responsive promoter elements (TRE), the recognition site for the transcription factor AP-1.	Tetradecanoylphorbol Acetate	84-87	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-28
12945873-5	2003	With 0.1 micromol/l phorbol-12-myristate-13-acetate, GPIIb/IIIa activation was irreversible.	Tetradecanoylphorbol Acetate	20-51	integrin subunit alpha 2b	Homo sapiens	53-58
15647254-5	2005	A highly specific PKC beta inhibitor, LY379196, blocked dopamine efflux that was stimulated by either amphetamine or the PKC activator, 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	136-172	protein kinase C, beta	Rattus norvegicus	18-26
15647254-5	2005	A highly specific PKC beta inhibitor, LY379196, blocked dopamine efflux that was stimulated by either amphetamine or the PKC activator, 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	136-172	protein kinase C, alpha	Rattus norvegicus	18-21
2158073-1	1990	The nuclear oncoproteins fos and jun are associated as a heterodimer which binds to TPA (PMA or TPA: phorbol 12-myristate 13-acetate)- responsive promoter elements (TRE), the recognition site for the transcription factor AP-1.	Tetradecanoylphorbol Acetate	84-87	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	221-225
15743787-3	2005	U937 cells expressed low levels of an HMGB1/amphoterin receptor, receptor for advanced glycation end-products (RAGE), whereas RAGE production was induced in differentiated phorbol 12-myristate 13-acetate (PMA)-U937 cells.	Tetradecanoylphorbol Acetate	172-203	advanced glycosylation end-product specific receptor	Homo sapiens	126-130
15743787-3	2005	U937 cells expressed low levels of an HMGB1/amphoterin receptor, receptor for advanced glycation end-products (RAGE), whereas RAGE production was induced in differentiated phorbol 12-myristate 13-acetate (PMA)-U937 cells.	Tetradecanoylphorbol Acetate	205-208	advanced glycosylation end-product specific receptor	Homo sapiens	65-109
12755693-4	2003	This maturation is negatively influenced by the phorbol ester phorbol-12-myristate-13-acetate (PMA), which decreases the cellular amount of the mature form of TACE in PMA-treated HEK293 and SH-SY5Y cells.	Tetradecanoylphorbol Acetate	62-93	ADAM metallopeptidase domain 17	Homo sapiens	159-163
12755693-4	2003	This maturation is negatively influenced by the phorbol ester phorbol-12-myristate-13-acetate (PMA), which decreases the cellular amount of the mature form of TACE in PMA-treated HEK293 and SH-SY5Y cells.	Tetradecanoylphorbol Acetate	95-98	ADAM metallopeptidase domain 17	Homo sapiens	159-163
15743787-3	2005	U937 cells expressed low levels of an HMGB1/amphoterin receptor, receptor for advanced glycation end-products (RAGE), whereas RAGE production was induced in differentiated phorbol 12-myristate 13-acetate (PMA)-U937 cells.	Tetradecanoylphorbol Acetate	205-208	advanced glycosylation end-product specific receptor	Homo sapiens	126-130
2158073-1	1990	The nuclear oncoproteins fos and jun are associated as a heterodimer which binds to TPA (PMA or TPA: phorbol 12-myristate 13-acetate)- responsive promoter elements (TRE), the recognition site for the transcription factor AP-1.	Tetradecanoylphorbol Acetate	89-92	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-28
15538571-19	2005	PMA enhanced the effect of quercetin on the translocation of PKC-delta.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, delta	Mus musculus	61-70
2158073-1	1990	The nuclear oncoproteins fos and jun are associated as a heterodimer which binds to TPA (PMA or TPA: phorbol 12-myristate 13-acetate)- responsive promoter elements (TRE), the recognition site for the transcription factor AP-1.	Tetradecanoylphorbol Acetate	89-92	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	221-225
2158073-1	1990	The nuclear oncoproteins fos and jun are associated as a heterodimer which binds to TPA (PMA or TPA: phorbol 12-myristate 13-acetate)- responsive promoter elements (TRE), the recognition site for the transcription factor AP-1.	Tetradecanoylphorbol Acetate	96-99	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-28
2158073-1	1990	The nuclear oncoproteins fos and jun are associated as a heterodimer which binds to TPA (PMA or TPA: phorbol 12-myristate 13-acetate)- responsive promoter elements (TRE), the recognition site for the transcription factor AP-1.	Tetradecanoylphorbol Acetate	96-99	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	221-225
12755693-4	2003	This maturation is negatively influenced by the phorbol ester phorbol-12-myristate-13-acetate (PMA), which decreases the cellular amount of the mature form of TACE in PMA-treated HEK293 and SH-SY5Y cells.	Tetradecanoylphorbol Acetate	167-170	ADAM metallopeptidase domain 17	Homo sapiens	159-163
15572354-3	2005	Inhibition of PKC with GF109203X, Go6983, or Go6976 and down-regulation of PKC activity enhanced the release of Ca2+ from internal stores in response to the polyvalent cationic CaR agonist neomycin, whereas activation of PKC with acute 12-O-tetradecanoylphorbol-13-acetate treatment decreased the release.	Tetradecanoylphorbol Acetate	236-272	carbonic anhydrase 2	Homo sapiens	112-115
2158073-1	1990	The nuclear oncoproteins fos and jun are associated as a heterodimer which binds to TPA (PMA or TPA: phorbol 12-myristate 13-acetate)- responsive promoter elements (TRE), the recognition site for the transcription factor AP-1.	Tetradecanoylphorbol Acetate	101-132	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-28
12755693-8	2003	Moreover, the PMA dependent decrease of the mature enzyme form is specific for TACE, as the amount of mature ADAM10 was unaffected in PMA-treated HEK293 and SH-SY5Y cells.	Tetradecanoylphorbol Acetate	14-17	ADAM metallopeptidase domain 17	Homo sapiens	79-83
2158073-1	1990	The nuclear oncoproteins fos and jun are associated as a heterodimer which binds to TPA (PMA or TPA: phorbol 12-myristate 13-acetate)- responsive promoter elements (TRE), the recognition site for the transcription factor AP-1.	Tetradecanoylphorbol Acetate	101-132	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	221-225
2108866-4	1990	H-7 produced a shift to the right of the dose-response curve for the PKC activator, 12-o-tetradecanoylphorbol-13-acetate (TPA) in the case of SHR aortas, while no such shift was noted in tissues from WKY.	Tetradecanoylphorbol Acetate	122-125	solute carrier family 9 member A2	Rattus norvegicus	0-3
15498788-13	2005	When IH-901 was treated topically prior to TPA, expression and activity of ODC were inhibited dose-dependently.	Tetradecanoylphorbol Acetate	43-46	ornithine decarboxylase, structural 1	Mus musculus	75-78
2153360-0	1990	Modes of inhibitory action of 4 beta-phorbol 12-myristate 13-acetate in thrombin-stimulated arachidonic acid release in intact and permeabilized platelets.	Tetradecanoylphorbol Acetate	30-68	prothrombin	Oryctolagus cuniculus	72-80
15389577-2	2005	PMA stimulation induced ruffling and translocated cortactin to the plasma membrane.	Tetradecanoylphorbol Acetate	0-3	cortactin	Homo sapiens	50-59
12739001-2	2003	When K562 cells were induced to differentiate into the megakaryocyte lineage by treatment with TPA, the expression of the c-ets-1, Fli-1 and TEL2 genes was increased, and that of the TEL gene was decreased at the onset of differentiation.	Tetradecanoylphorbol Acetate	95-98	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	131-136
12745080-1	2003	In isolated rat pancreatic acini, protein expression of RhoA and Rho-associated kinase, ROCK-II, and the formation of immunocomplex of RhoA with ROCK-II were enhanced by CCK-8, carbachol, and the phorbol ester TPA.	Tetradecanoylphorbol Acetate	210-213	ras homolog family member A	Rattus norvegicus	56-60
15389577-10	2005	We conclude that PMA-induced membrane ruffling is caused via ARF6-Rac1 and ARF1 pathways operating in parallel and that PLD may be inhibitory.	Tetradecanoylphorbol Acetate	17-20	Rac family small GTPase 1	Homo sapiens	66-70
12745080-1	2003	In isolated rat pancreatic acini, protein expression of RhoA and Rho-associated kinase, ROCK-II, and the formation of immunocomplex of RhoA with ROCK-II were enhanced by CCK-8, carbachol, and the phorbol ester TPA.	Tetradecanoylphorbol Acetate	210-213	ras homolog family member A	Rattus norvegicus	135-139
15389577-10	2005	We conclude that PMA-induced membrane ruffling is caused via ARF6-Rac1 and ARF1 pathways operating in parallel and that PLD may be inhibitory.	Tetradecanoylphorbol Acetate	17-20	ADP ribosylation factor 1	Homo sapiens	75-79
2153360-1	1990	The tumor-promoting phorbol ester 4 beta-phorbol 12-myristate 13-acetate (PMA) inhibited thrombin-stimulated arachidonic acid (AA) release in rabbit and human platelets.	Tetradecanoylphorbol Acetate	36-72	prothrombin	Oryctolagus cuniculus	89-97
12745080-1	2003	In isolated rat pancreatic acini, protein expression of RhoA and Rho-associated kinase, ROCK-II, and the formation of immunocomplex of RhoA with ROCK-II were enhanced by CCK-8, carbachol, and the phorbol ester TPA.	Tetradecanoylphorbol Acetate	210-213	cholecystokinin	Rattus norvegicus	170-173
2153360-1	1990	The tumor-promoting phorbol ester 4 beta-phorbol 12-myristate 13-acetate (PMA) inhibited thrombin-stimulated arachidonic acid (AA) release in rabbit and human platelets.	Tetradecanoylphorbol Acetate	74-77	prothrombin	Oryctolagus cuniculus	89-97
12522006-1	2003	Monocytic differentiation of 32DPKCdelta cells in response to activation of protein kinase C delta (PKCdelta) by phorbol 12-myristate 13-acetate (PMA) was inhibited by exogenous CCAAT/enhancer binding protein alpha-estradiol receptor (C/EBPalpha-ER), which impeded morphologic maturation and induction of macrosialin mRNA.	Tetradecanoylphorbol Acetate	113-144	CD68 molecule	Homo sapiens	305-316
15695610-5	2005	We identified an interaction between actin and the PKC alpha isoenzyme in non-activated metaphase II (MII) eggs and in eggs activated by phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	151-188	protein kinase C, alpha	Rattus norvegicus	51-60
2153360-2	1990	PMA was effective over the same concentration range that activates protein kinase C in intact rabbit platelets: IC50 vs thrombin = 0.5 nM, greater than 90% inhibition at 10 nM.	Tetradecanoylphorbol Acetate	0-3	prothrombin	Oryctolagus cuniculus	120-128
15695610-5	2005	We identified an interaction between actin and the PKC alpha isoenzyme in non-activated metaphase II (MII) eggs and in eggs activated by phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	190-193	protein kinase C, alpha	Rattus norvegicus	51-60
2153360-3	1990	Suppression of thrombin-stimulated AA release was evident within 5 min of pretreatment with 1 nM PMA.	Tetradecanoylphorbol Acetate	97-100	prothrombin	Oryctolagus cuniculus	15-23
2153360-8	1990	PMA pretreatment reduced the inhibitory effect of thrombin on forskolin-stimulated cAMP accumulation, but had no effect on nonstimulated cAMP metabolism in the presence of thrombin.	Tetradecanoylphorbol Acetate	0-3	prothrombin	Oryctolagus cuniculus	50-58
15574370-11	2005	The binding of tPA and plasmin to S100A10 also protects against inhibition by physiological inhibitors, PAI-1 and alpha2-antiplasmin, respectively.	Tetradecanoylphorbol Acetate	15-18	serpin family F member 2	Homo sapiens	114-132
12856808-3	2003	Semi-quantitative RT-PCR revealed that the effect of forskolin was attenuated by the addition of phorbol ester, tetradecanoyl phorbol acetate (TPA), an activator of the protein kinase C (PKC) pathway, whereas TPA on its own slightly reduced the basal level of 11betaHSD2 expression judging from the content of specific mRNA.	Tetradecanoylphorbol Acetate	112-141	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	260-270
12856808-3	2003	Semi-quantitative RT-PCR revealed that the effect of forskolin was attenuated by the addition of phorbol ester, tetradecanoyl phorbol acetate (TPA), an activator of the protein kinase C (PKC) pathway, whereas TPA on its own slightly reduced the basal level of 11betaHSD2 expression judging from the content of specific mRNA.	Tetradecanoylphorbol Acetate	143-146	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	260-270
2153360-10	1990	In digitonin-permeabilized platelets, thrombin plus guanosine 5"-(3-O-thio)triphosphate (GTP gamma S)-stimulated AA release, but not GTP gamma S- and AIF4(-)-stimulated AA release, was abolished by PMA pretreatment.	Tetradecanoylphorbol Acetate	198-201	prothrombin	Oryctolagus cuniculus	38-46
12856808-5	2003	Phorbol ester TPA markedly reduced the effect of forskolin on the synthesis of 11betaHSD2 and attenuated the basal level of synthesis of this protein.	Tetradecanoylphorbol Acetate	14-17	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	79-89
16156954-4	2005	Topical application of TPA alone in mouse skin enhances ornithine decarboxylase activity and also increases [3H]-thymidine incorporation in DNA.	Tetradecanoylphorbol Acetate	23-26	ornithine decarboxylase, structural 1	Mus musculus	56-79
2127691-6	1990	In a Xenopus kidney cell line, the fos gene can be transcriptionally activated by serum growth factors and 12-O-tetradecanoylphorbol-13-acetate, and the fos mRNA can be superinduced by cycloheximide.	Tetradecanoylphorbol Acetate	107-143	FBJ murine osteosarcoma viral oncogene homolog S homeolog	Xenopus laevis	35-38
15271671-4	2004	PMA induced nuclear translocation of endogenous and AdV-WT PKC-alpha in NRVMs.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	59-68
12707358-8	2003	In coimmunoprecipitation experiments, IKKalpha/beta was found to be associated with c-Src and to be phosphorylated on its tyrosine residues after TNF-alpha or TPA treatment.	Tetradecanoylphorbol Acetate	159-162	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	38-51
2127691-10	1990	Furthermore, the Xenopus fos protein collaborates with mammalian jun protein to activate transcription from 12-O-tetradecanoylphorbol-13-acetate-responsive element.	Tetradecanoylphorbol Acetate	108-144	FBJ murine osteosarcoma viral oncogene homolog S homeolog	Xenopus laevis	25-28
12590140-6	2003	The binding of KLF6 to the iNOS promoter was significantly increased in Jurkat cells, primary T lymphocytes, and COS-7 cells subjected to NaCN-induced hypoxia, heat shock, serum starvation, and phorbol 12-myristate 13-acetate/ ionophore stimulation.	Tetradecanoylphorbol Acetate	194-225	Kruppel like factor 6	Homo sapiens	15-19
15271671-15	2004	However, AdV-DN PKC-alpha partially blocked PMA-induced ERK activation.	Tetradecanoylphorbol Acetate	44-47	protein kinase C, alpha	Rattus norvegicus	16-25
2293979-5	1990	Incubation of the cells with 100 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in transient translocation of PKC activity to the membrane (15 min) which was followed by a 64% decrease in total cellular enzyme activity after 3 h. In PKC-depleted cells, the aldosterone response to ACTH was increased by 25% but AII-stimulated steroidogenesis was unchanged.	Tetradecanoylphorbol Acetate	36-72	protein kinase C, gamma	Rattus norvegicus	118-121
15307820-4	2004	In the present study, we show that PMA treatment increases glucose uptake in 3T3-L1 adipocytes by two mechanisms: a mitogen-activated protein kinase kinase-dependent increase in GLUT1 (glucose transporter 1) expression levels and a PKClambda-dependent translocation of GLUT1 towards the plasma membrane.	Tetradecanoylphorbol Acetate	35-38	solute carrier family 2 member 1	Homo sapiens	178-183
15307820-4	2004	In the present study, we show that PMA treatment increases glucose uptake in 3T3-L1 adipocytes by two mechanisms: a mitogen-activated protein kinase kinase-dependent increase in GLUT1 (glucose transporter 1) expression levels and a PKClambda-dependent translocation of GLUT1 towards the plasma membrane.	Tetradecanoylphorbol Acetate	35-38	solute carrier family 2 member 1	Homo sapiens	185-206
15307820-4	2004	In the present study, we show that PMA treatment increases glucose uptake in 3T3-L1 adipocytes by two mechanisms: a mitogen-activated protein kinase kinase-dependent increase in GLUT1 (glucose transporter 1) expression levels and a PKClambda-dependent translocation of GLUT1 towards the plasma membrane.	Tetradecanoylphorbol Acetate	35-38	solute carrier family 2 member 1	Homo sapiens	269-274
12700661-7	2003	In small resting (G0) B cells, costimulation with PMA and ionomycin, but not PMA or ionomycin alone, induces cyclin D2 expression and cell-cycle progression.	Tetradecanoylphorbol Acetate	50-53	cyclin D2	Mus musculus	109-118
2293979-5	1990	Incubation of the cells with 100 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in transient translocation of PKC activity to the membrane (15 min) which was followed by a 64% decrease in total cellular enzyme activity after 3 h. In PKC-depleted cells, the aldosterone response to ACTH was increased by 25% but AII-stimulated steroidogenesis was unchanged.	Tetradecanoylphorbol Acetate	36-72	protein kinase C, gamma	Rattus norvegicus	241-244
12651162-8	2003	HEK293 cells stably overexpressing Trespin display increased cell proliferation and partial resistance to growth inhibition and phosphorylation of c-Jun induced by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	182-218	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	147-152
15308560-0	2004	Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation.	Tetradecanoylphorbol Acetate	49-74	phospholipid scramblase 1	Homo sapiens	83-108
2293979-5	1990	Incubation of the cells with 100 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in transient translocation of PKC activity to the membrane (15 min) which was followed by a 64% decrease in total cellular enzyme activity after 3 h. In PKC-depleted cells, the aldosterone response to ACTH was increased by 25% but AII-stimulated steroidogenesis was unchanged.	Tetradecanoylphorbol Acetate	74-77	protein kinase C, gamma	Rattus norvegicus	118-121
15541021-4	2004	Addition of 12-O-tetradecanoyl-phorbol-13-acetate (10 ng/ml) to the culture medium caused an increase of production of MMP-2 and MMP-9 by cultured uveal melanocytes, and also stimulated the transcription of MMP-2 and MMP-9 of these cells.	Tetradecanoylphorbol Acetate	12-49	matrix metallopeptidase 9	Homo sapiens	129-134
15541021-4	2004	Addition of 12-O-tetradecanoyl-phorbol-13-acetate (10 ng/ml) to the culture medium caused an increase of production of MMP-2 and MMP-9 by cultured uveal melanocytes, and also stimulated the transcription of MMP-2 and MMP-9 of these cells.	Tetradecanoylphorbol Acetate	12-49	matrix metallopeptidase 9	Homo sapiens	217-222
12689660-11	2003	CD11b(+)Gr-1(+) cells isolated from the blood or spleen of TCDD-treated mice produced up to fivefold higher levels of superoxide following PMA stimulation when compared with cells from vehicle-treated mice.	Tetradecanoylphorbol Acetate	139-142	integrin subunit alpha M	Homo sapiens	0-5
2293979-5	1990	Incubation of the cells with 100 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in transient translocation of PKC activity to the membrane (15 min) which was followed by a 64% decrease in total cellular enzyme activity after 3 h. In PKC-depleted cells, the aldosterone response to ACTH was increased by 25% but AII-stimulated steroidogenesis was unchanged.	Tetradecanoylphorbol Acetate	74-77	protein kinase C, gamma	Rattus norvegicus	241-244
2293979-6	1990	In contrast, in cells in which PKC was translocated to the membrane by a 15 min preincubation with TPA, aldosterone response to AII was enhanced by 40%, while the response to ACTH was reduced by 30%; under these conditions membrane PKC levels rapidly returned to basal.	Tetradecanoylphorbol Acetate	99-102	protein kinase C, gamma	Rattus norvegicus	31-34
2293979-6	1990	In contrast, in cells in which PKC was translocated to the membrane by a 15 min preincubation with TPA, aldosterone response to AII was enhanced by 40%, while the response to ACTH was reduced by 30%; under these conditions membrane PKC levels rapidly returned to basal.	Tetradecanoylphorbol Acetate	99-102	protein kinase C, gamma	Rattus norvegicus	232-235
15477007-6	2004	We found that both inhibited the increase in expression of many of the genes, including IL-2 and MKP-2, that were induced early after stimulation of lymphocytes with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	166-191	dual specificity phosphatase 4	Homo sapiens	97-102
2293979-11	1990	However, the fact that aldosterone responses to AII are potentiated during TPA-induced PKC translocation to the membrane suggests that AII and phorbol esters do not share the same mechanism of action in the regulation of steroidogenesis.	Tetradecanoylphorbol Acetate	75-78	protein kinase C, gamma	Rattus norvegicus	87-90
2090920-7	1990	Addition of phorbol 12-myristate 13-acetate (PMA) or IL-4 to the culture of BCL1-B20 cells inhibited both the IL-5-mediated augmentation of IgM secretion and the elevated expression of c-myc mRNA.	Tetradecanoylphorbol Acetate	12-43	cyclin D1	Mus musculus	76-80
15522912-6	2004	Treatment of HepG2 cells with CA (100 microg/mL) and CAPE (5 microg/mL) suppressed phorbol 12-myristate 13-acetate (PMA) -induced MMP-9 expression by inhibiting the function of NF-kappaB, but not AP-1.	Tetradecanoylphorbol Acetate	83-114	matrix metallopeptidase 9	Homo sapiens	130-135
12668279-7	2003	Since TPA-induced epidermal ornithine decarboxylase (ODC) activity and [(3)H]thymidine incorporation are conventionally used markers of skin tumor promotion, we also assessed the effect of pre-application of palm oil on these parameters, and it was observed that the application of palm oil prior to the application of TPA alleviated both these TPA-induced markers of tumor promotion.	Tetradecanoylphorbol Acetate	6-9	ornithine decarboxylase, structural 1	Mus musculus	28-51
12668279-7	2003	Since TPA-induced epidermal ornithine decarboxylase (ODC) activity and [(3)H]thymidine incorporation are conventionally used markers of skin tumor promotion, we also assessed the effect of pre-application of palm oil on these parameters, and it was observed that the application of palm oil prior to the application of TPA alleviated both these TPA-induced markers of tumor promotion.	Tetradecanoylphorbol Acetate	6-9	ornithine decarboxylase, structural 1	Mus musculus	53-56
15522912-6	2004	Treatment of HepG2 cells with CA (100 microg/mL) and CAPE (5 microg/mL) suppressed phorbol 12-myristate 13-acetate (PMA) -induced MMP-9 expression by inhibiting the function of NF-kappaB, but not AP-1.	Tetradecanoylphorbol Acetate	116-119	matrix metallopeptidase 9	Homo sapiens	130-135
2090920-7	1990	Addition of phorbol 12-myristate 13-acetate (PMA) or IL-4 to the culture of BCL1-B20 cells inhibited both the IL-5-mediated augmentation of IgM secretion and the elevated expression of c-myc mRNA.	Tetradecanoylphorbol Acetate	45-48	cyclin D1	Mus musculus	76-80
12645577-10	2003	Substitution of these residues with phenylalanines abolished ICAM-1 promoter activity and c-Src-dependent phosphorylation of IKKbeta induced by TNF-alpha or TPA.	Tetradecanoylphorbol Acetate	157-160	intercellular adhesion molecule 1	Homo sapiens	61-67
2157183-7	1990	In fact, the expression of E1A rendered the c-jun gene hypersensitive to TPA induction.	Tetradecanoylphorbol Acetate	73-76	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	44-49
12620479-7	2003	RESULT(S): Phorbol 12-myristate 13-acetate elicited an increase in MMP-9 and TIMP-1 secretion in both groups and apparently did not affect progesterone secretion.	Tetradecanoylphorbol Acetate	11-42	matrix metallopeptidase 9	Homo sapiens	67-72
15838289-4	2004	Chelerythrine and prolonged exposure to phorbol 12-myristate 13-acetate abolished the activation of NCX1 induced by endothelin-1.	Tetradecanoylphorbol Acetate	40-71	endothelin-1	Sus scrofa	116-128
15292277-2	2004	Here, we show that SHP expression increases during monocytic differentiaton with exposure HL-60 leukemia cells to a 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, whose treatment induced the SHP promoter activity dependent on c-Jun expression, which is well known to be involved in the commitment step in the TPA-induced differentiation of HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	116-152	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	240-245
2217443-11	1990	Among the megakaryocytic phenotypes, increase in GPIIb/IIIa complex, determined by a biochemical method, PPO by ultrastructural study, and the increase in cellular ploidy were clearly observed by PMA treatment.	Tetradecanoylphorbol Acetate	196-199	integrin subunit alpha 2b	Homo sapiens	49-54
15292277-2	2004	Here, we show that SHP expression increases during monocytic differentiaton with exposure HL-60 leukemia cells to a 12-O-tetradecanoylphorbol-13-acetate (TPA) response element, whose treatment induced the SHP promoter activity dependent on c-Jun expression, which is well known to be involved in the commitment step in the TPA-induced differentiation of HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	154-157	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	240-245
15292277-4	2004	Electrophoretic mobility shift assays using oligonucleotides derived from the SHP promoter reveal that c-Jun exhibit TPA-induced DNA binding, providing a mechanism for the transcriptional activation of SHP gene expression.	Tetradecanoylphorbol Acetate	117-120	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-108
15292277-5	2004	It was also found that overexpression of SHP and c-Jun greatly facilitated monocytic differentiation by TPA and surprisingly, that expression of SHP or c-Jun alone was sufficient to make cells differentiate into functionally mature monocytes, but silencing of SHP and c-Jun by RNA interference diminished the TPA-induced monocytic differentiation.	Tetradecanoylphorbol Acetate	104-107	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-54
12554796-3	2003	Forskolin/phorbol myristate (PMA) induced PR promoter-luciferase reporter activity in granulosa cells greater than 15-fold.	Tetradecanoylphorbol Acetate	29-32	progesterone receptor	Mus musculus	42-44
12592382-3	2003	During this period, phosphorylation of one of the downstream transcriptional factors of MAPK cascade, ATF2, was 3.2- and 2.0-fold induced by TPA and Saikosaponin a, respectively, whereas that of another transcriptional factor, c-jun, was induced by TPA only.	Tetradecanoylphorbol Acetate	249-252	activating transcription factor 2	Homo sapiens	102-106
12592382-4	2003	On the other hand, expressions of proto-oncogene c-jun, junB and c-fos were induced by TPA and Saikosaponin a during 30 min to 6 h of treatment.	Tetradecanoylphorbol Acetate	87-90	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-54
12592382-4	2003	On the other hand, expressions of proto-oncogene c-jun, junB and c-fos were induced by TPA and Saikosaponin a during 30 min to 6 h of treatment.	Tetradecanoylphorbol Acetate	87-90	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-70
15372680-1	2004	The reaction of [FeII(tpa)(OTf)2] (tpa=tris(2-pyridylmethyl)amine) and its related 5-Me3-tpa complex with hydrogen peroxide affords spectroscopically distinct iron(III)-peroxo intermediates in CH3CN and acetone.	Tetradecanoylphorbol Acetate	22-25	POU class 2 homeobox 2	Homo sapiens	27-32
15372680-1	2004	The reaction of [FeII(tpa)(OTf)2] (tpa=tris(2-pyridylmethyl)amine) and its related 5-Me3-tpa complex with hydrogen peroxide affords spectroscopically distinct iron(III)-peroxo intermediates in CH3CN and acetone.	Tetradecanoylphorbol Acetate	35-38	POU class 2 homeobox 2	Homo sapiens	27-32
22073254-5	2011	PMA/ionomycin-induced lytic granule exocytosis was preceded by a rapid association of the docking molecule Rab27a to approximately half of the lytic granules.	Tetradecanoylphorbol Acetate	0-3	RAB27A, member RAS oncogene family	Homo sapiens	107-113
15258160-3	2004	RAW 264.7 macrophages were first stimulated with interferon-gamma and lipopolysaccharide (IFN-gamma/LPS) and then triggered by phorbol 12-myristate 13-acetate (PMA) in order to promote co-generation of NO* and O*2-.. IRP-1 was isolated by immunoprecipitation and analyzed for protein-bound nitrotyrosine by Western blotting.	Tetradecanoylphorbol Acetate	160-163	aconitase 1	Mus musculus	217-222
15258160-7	2004	IRP-1 nitration was strongly reduced when IFN-gamma/LPS/PMA-stimulated cells were incubated with myeloperoxidase inhibitors, which points to the contribution of the nitrite/H2O2/peroxidase pathway to IRP-1 nitration in vivo.	Tetradecanoylphorbol Acetate	56-59	aconitase 1	Mus musculus	0-5
15258160-7	2004	IRP-1 nitration was strongly reduced when IFN-gamma/LPS/PMA-stimulated cells were incubated with myeloperoxidase inhibitors, which points to the contribution of the nitrite/H2O2/peroxidase pathway to IRP-1 nitration in vivo.	Tetradecanoylphorbol Acetate	56-59	myeloperoxidase	Mus musculus	97-112
15258160-7	2004	IRP-1 nitration was strongly reduced when IFN-gamma/LPS/PMA-stimulated cells were incubated with myeloperoxidase inhibitors, which points to the contribution of the nitrite/H2O2/peroxidase pathway to IRP-1 nitration in vivo.	Tetradecanoylphorbol Acetate	56-59	aconitase 1	Mus musculus	200-205
12592382-6	2003	Inductions of c-fos RNA by both drugs and c-jun phosphorylation by TPA were also significantly reduced by PD98059 pretreatment.	Tetradecanoylphorbol Acetate	67-70	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
12592382-6	2003	Inductions of c-fos RNA by both drugs and c-jun phosphorylation by TPA were also significantly reduced by PD98059 pretreatment.	Tetradecanoylphorbol Acetate	67-70	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-47
12592382-7	2003	In addition, AP-1 DNA-binding assay using nonisotopic capillary electrophoresis and laser-induced fluorescence (CE/LIF) demonstrated that the AP-1-related DNA-binding activity was significantly induced by TPA and Saikosaponin a, which can be reduced by PD98059 pretreatment.	Tetradecanoylphorbol Acetate	205-208	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-17
12592382-7	2003	In addition, AP-1 DNA-binding assay using nonisotopic capillary electrophoresis and laser-induced fluorescence (CE/LIF) demonstrated that the AP-1-related DNA-binding activity was significantly induced by TPA and Saikosaponin a, which can be reduced by PD98059 pretreatment.	Tetradecanoylphorbol Acetate	205-208	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	142-146
11060311-6	2001	Activation of ERKs and JNKs by phorbol 12-myristate 13-acetate and tumor necrosis factor alpha, respectively, leading to increased MMP-9 amounts was not antagonized by KiSS-1 expression, suggesting that MAPK pathways modulating MMP-9 synthesis are not the target of KiSS-1.	Tetradecanoylphorbol Acetate	31-62	matrix metallopeptidase 9	Homo sapiens	131-136
12582025-6	2003	The effects of alpha-santalol treatment on TPA-induced epidermal ornithine decarboxylase (ODC) activity and (3)H-thymidine incorporation in epidermal DNA of CD-1 and SENCAR mice were also investigated.	Tetradecanoylphorbol Acetate	43-46	ornithine decarboxylase, structural 1	Mus musculus	65-88
15166090-7	2004	Thus, increased thioredoxin-1 in keratinocytes acts as an enhancer of carcinogenesis in the DMBA/TPA two-stage model of skin carcinogenesis in mice.	Tetradecanoylphorbol Acetate	97-100	thioredoxin 1	Mus musculus	16-29
15354318-4	2004	However, the ornithine decarboxylase (ODC) activity and unscheduled DNA synthesis are elevated on single topical application of TPA to the dorsal cutaneous portions of the mice.	Tetradecanoylphorbol Acetate	128-131	ornithine decarboxylase, structural 1	Mus musculus	13-36
12582025-6	2003	The effects of alpha-santalol treatment on TPA-induced epidermal ornithine decarboxylase (ODC) activity and (3)H-thymidine incorporation in epidermal DNA of CD-1 and SENCAR mice were also investigated.	Tetradecanoylphorbol Acetate	43-46	ornithine decarboxylase, structural 1	Mus musculus	90-93
11060311-6	2001	Activation of ERKs and JNKs by phorbol 12-myristate 13-acetate and tumor necrosis factor alpha, respectively, leading to increased MMP-9 amounts was not antagonized by KiSS-1 expression, suggesting that MAPK pathways modulating MMP-9 synthesis are not the target of KiSS-1.	Tetradecanoylphorbol Acetate	31-62	matrix metallopeptidase 9	Homo sapiens	228-233
12582025-9	2003	alpha-Santalol treatment resulted in a significant (P &lt; 0.05) inhibition in TPA-induced ODC activity and incorporation of (3)H-thymidine in DNA in the epidermis of both strains of mice.	Tetradecanoylphorbol Acetate	79-82	ornithine decarboxylase, structural 1	Mus musculus	91-94
15354318-4	2004	However, the ornithine decarboxylase (ODC) activity and unscheduled DNA synthesis are elevated on single topical application of TPA to the dorsal cutaneous portions of the mice.	Tetradecanoylphorbol Acetate	128-131	ornithine decarboxylase, structural 1	Mus musculus	38-41
15354318-5	2004	Topical applications of soy isoflavones, half-an-hour prior to the application of TPA prevented the induction of ODC activity and DNA synthesis mediated by TPA (p &lt; 0.01).	Tetradecanoylphorbol Acetate	82-85	ornithine decarboxylase, structural 1	Mus musculus	113-116
7818761-1	1995	This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain.	Tetradecanoylphorbol Acetate	102-138	ornithine decarboxylase, structural 1	Mus musculus	197-220
15354318-5	2004	Topical applications of soy isoflavones, half-an-hour prior to the application of TPA prevented the induction of ODC activity and DNA synthesis mediated by TPA (p &lt; 0.01).	Tetradecanoylphorbol Acetate	156-159	ornithine decarboxylase, structural 1	Mus musculus	113-116
7818761-1	1995	This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain.	Tetradecanoylphorbol Acetate	102-138	ornithine decarboxylase, structural 1	Mus musculus	222-225
12464393-7	2003	PMA increased the amount of membrane-associated, inactive PKC.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, gamma	Rattus norvegicus	58-61
7818761-1	1995	This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain.	Tetradecanoylphorbol Acetate	140-143	ornithine decarboxylase, structural 1	Mus musculus	197-220
15625319-2	2004	Challenging [(3)H]Sph-labeled platelet suspensions with thrombin or 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in a decrease in Sph-1-P formation and an increase in sphingosine (Sph), ceramide (Cer), and sphingomyelin formation.	Tetradecanoylphorbol Acetate	68-104	ankyrin 1	Homo sapiens	137-142
15625319-2	2004	Challenging [(3)H]Sph-labeled platelet suspensions with thrombin or 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in a decrease in Sph-1-P formation and an increase in sphingosine (Sph), ceramide (Cer), and sphingomyelin formation.	Tetradecanoylphorbol Acetate	106-109	ankyrin 1	Homo sapiens	137-142
7818761-1	1995	This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain.	Tetradecanoylphorbol Acetate	140-143	ornithine decarboxylase, structural 1	Mus musculus	222-225
15625319-5	2004	When quantified with [(3)H]acetic anhydride acetylation, followed by HPLC separation, the amounts of Sph-1-P and Sph decreased and increased, respectively, upon stimulation with thrombin or TPA, and these changes were attenuated by staurosporine.	Tetradecanoylphorbol Acetate	190-193	ankyrin 1	Homo sapiens	101-106
15625319-6	2004	Under these TPA treatment conditions, over half of the [(3)H]Sph-1-P (formed in platelets incubated with [(3)H]Sph) was detected extracellularly, possibly due to its release from platelets, which was completely inhibited by staurosporine pretreatment.	Tetradecanoylphorbol Acetate	12-15	ankyrin 1	Homo sapiens	61-66
15625319-7	2004	Furthermore, when TPA-induced Sph-1-P release was blocked by staurosporine after the stimulation, the extracellular [(3)H]Sph-1-P radioactivity decreased, suggesting that the Sph-1-P released may undergo dephosphorylation extracellularly.	Tetradecanoylphorbol Acetate	18-21	ankyrin 1	Homo sapiens	30-35
7818761-2	1995	Northern blot analysis demonstrated that a single promoting dose of TPA induced ODC mRNA expression 10- to 15-fold in both strains.	Tetradecanoylphorbol Acetate	68-71	ornithine decarboxylase, structural 1	Mus musculus	80-83
15625319-7	2004	Furthermore, when TPA-induced Sph-1-P release was blocked by staurosporine after the stimulation, the extracellular [(3)H]Sph-1-P radioactivity decreased, suggesting that the Sph-1-P released may undergo dephosphorylation extracellularly.	Tetradecanoylphorbol Acetate	18-21	ankyrin 1	Homo sapiens	122-127
15625319-7	2004	Furthermore, when TPA-induced Sph-1-P release was blocked by staurosporine after the stimulation, the extracellular [(3)H]Sph-1-P radioactivity decreased, suggesting that the Sph-1-P released may undergo dephosphorylation extracellularly.	Tetradecanoylphorbol Acetate	18-21	ankyrin 1	Homo sapiens	122-127
12631113-11	2003	Incubation of MCs with phorbol myristate acetate (PMA) for four hours resulted in an increase in fractalkine mRNA expression that could be suppressed by calphostin C or depletion of PKC by pretreatment with PMA for 24 hours.	Tetradecanoylphorbol Acetate	23-48	protein kinase C zeta	Homo sapiens	182-185
7818761-3	1995	Treatment of each strain with a second dose of TPA, 48 h (in C57BL/6 mice) or 72 h (in SSIN mice) after the first, led to hyperinduction of ODC activity.	Tetradecanoylphorbol Acetate	47-50	ornithine decarboxylase, structural 1	Mus musculus	140-143
12631113-11	2003	Incubation of MCs with phorbol myristate acetate (PMA) for four hours resulted in an increase in fractalkine mRNA expression that could be suppressed by calphostin C or depletion of PKC by pretreatment with PMA for 24 hours.	Tetradecanoylphorbol Acetate	50-53	protein kinase C zeta	Homo sapiens	182-185
1801827-0	1991	Alpha-1 antichymotrypsin is increased in human alveolar macrophages by phorbol myristate acetate or lipopolysaccharide and released from these activated macrophages by glucocorticoid.	Tetradecanoylphorbol Acetate	71-96	serpin family A member 3	Homo sapiens	0-24
12631113-11	2003	Incubation of MCs with phorbol myristate acetate (PMA) for four hours resulted in an increase in fractalkine mRNA expression that could be suppressed by calphostin C or depletion of PKC by pretreatment with PMA for 24 hours.	Tetradecanoylphorbol Acetate	207-210	protein kinase C zeta	Homo sapiens	182-185
15377337-9	2004	Upon stimulation of the cultured cells with 12-O-tetradecanoyl-phorbol-13-acetate, tumour necrosis factor-alpha, lipopolysaccharide or H2O2, DCD mRNA expression was not detected in primary keratinocytes, fibroblasts and melanocytes, but was detected in MeWo and SKMEL28 melanoma cells.	Tetradecanoylphorbol Acetate	44-81	dermcidin	Homo sapiens	141-144
34958827-9	2022	Norepinephrine (NE), PMA and m-3M3FBS were used to activate alpha-1 adrenergic signaling.	Tetradecanoylphorbol Acetate	21-24	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	60-67
15344912-6	2004	We show that, in these cells, the phorbol esters 4beta-phorbol 12-myristate 13-acetate (PMA) or phorbol 12,13-dibutyrate have a direct stimulatory effect and induced 4-10-fold increases in AANAT protein levels, AANAT activity and melatonin production.	Tetradecanoylphorbol Acetate	49-86	serotonin N-acetyltransferase	Bos taurus	189-194
15344912-6	2004	We show that, in these cells, the phorbol esters 4beta-phorbol 12-myristate 13-acetate (PMA) or phorbol 12,13-dibutyrate have a direct stimulatory effect and induced 4-10-fold increases in AANAT protein levels, AANAT activity and melatonin production.	Tetradecanoylphorbol Acetate	49-86	serotonin N-acetyltransferase	Bos taurus	211-216
15344912-6	2004	We show that, in these cells, the phorbol esters 4beta-phorbol 12-myristate 13-acetate (PMA) or phorbol 12,13-dibutyrate have a direct stimulatory effect and induced 4-10-fold increases in AANAT protein levels, AANAT activity and melatonin production.	Tetradecanoylphorbol Acetate	88-91	serotonin N-acetyltransferase	Bos taurus	189-194
15344912-6	2004	We show that, in these cells, the phorbol esters 4beta-phorbol 12-myristate 13-acetate (PMA) or phorbol 12,13-dibutyrate have a direct stimulatory effect and induced 4-10-fold increases in AANAT protein levels, AANAT activity and melatonin production.	Tetradecanoylphorbol Acetate	88-91	serotonin N-acetyltransferase	Bos taurus	211-216
15328001-2	2004	AMPK activated with either 5"-aminoimidazole-4-carboxamide ribonucleoside (AICAR) or with 5"-AMP significantly attenuated both phorbol 12-myristate 13-acetate (PMA) and formyl methionyl leucyl phenylalanine-stimulated superoxide anion O2- release by human neutrophils, consistently with a reduced translocation to the cell membrane and phosphorylation of a cytosolic component of NADPH oxidase, namely p47phox.	Tetradecanoylphorbol Acetate	127-158	neutrophil cytosolic factor 1	Homo sapiens	402-409
15328001-2	2004	AMPK activated with either 5"-aminoimidazole-4-carboxamide ribonucleoside (AICAR) or with 5"-AMP significantly attenuated both phorbol 12-myristate 13-acetate (PMA) and formyl methionyl leucyl phenylalanine-stimulated superoxide anion O2- release by human neutrophils, consistently with a reduced translocation to the cell membrane and phosphorylation of a cytosolic component of NADPH oxidase, namely p47phox.	Tetradecanoylphorbol Acetate	160-163	neutrophil cytosolic factor 1	Homo sapiens	402-409
15358181-3	2004	After the AP-1 inhibition by curcumin analogs in TPA-treated HT-1080 human fibrosarcoma cells, a decrease in mRNA expression of c-jun and MMP3 (stromelysin-1) has been observed.	Tetradecanoylphorbol Acetate	49-52	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	10-14
15279563-9	2004	MAO B, but not MAO A gene, could be activated by PMA (phorbol 12-myristate 13-acetate) by protein kinase C, MAPkinase signal transduction pathway involves cJun and Egr-1.	Tetradecanoylphorbol Acetate	49-52	monoamine oxidase B	Homo sapiens	0-5
15345372-1	2004	Previous research demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment increased the number of skin papillomas in v-Ha-ras transgenic (Tg.AC) mice that had received sodium arsenite [(As(III)] in drinking water, indicating that this model is useful for studying the toxic effects of arsenic in vivo.	Tetradecanoylphorbol Acetate	36-72	Harvey rat sarcoma virus oncogene	Mus musculus	134-140
15345372-1	2004	Previous research demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment increased the number of skin papillomas in v-Ha-ras transgenic (Tg.AC) mice that had received sodium arsenite [(As(III)] in drinking water, indicating that this model is useful for studying the toxic effects of arsenic in vivo.	Tetradecanoylphorbol Acetate	74-77	Harvey rat sarcoma virus oncogene	Mus musculus	134-140
14961054-7	2004	Furthermore, the phenylephrine concentration-response curve was potentiated in the presence of phorbol 12-myristate13-acetate (PMA) (0.1 microM), a PKC activator (EC50: phenylephrine 1.0 +/- 0.8 microM vs phenylephrine + PMA 0.3 +/- 0.1 microM) and inhibited in the presence of chelerythrine chloride (30 microM), a PKC inhibitor (EC50: phenylephrine 1.0 +/- 0.8 microM vs phenylephrine + chelerythrine chloride 5.7 +/- 2.4 microM).	Tetradecanoylphorbol Acetate	95-125	protein kinase C, alpha	Rattus norvegicus	148-151
14961054-7	2004	Furthermore, the phenylephrine concentration-response curve was potentiated in the presence of phorbol 12-myristate13-acetate (PMA) (0.1 microM), a PKC activator (EC50: phenylephrine 1.0 +/- 0.8 microM vs phenylephrine + PMA 0.3 +/- 0.1 microM) and inhibited in the presence of chelerythrine chloride (30 microM), a PKC inhibitor (EC50: phenylephrine 1.0 +/- 0.8 microM vs phenylephrine + chelerythrine chloride 5.7 +/- 2.4 microM).	Tetradecanoylphorbol Acetate	127-130	protein kinase C, alpha	Rattus norvegicus	148-151
15282324-3	2004	We report here that CCND1 promoter activation by estrogens in human breast cancer cells is mediated by recruitment of a c-Jun/c-Fos/estrogen receptor alpha complex to the tetradecanoyl phorbol acetate-responsive element of the gene, together with Oct-1 to a site immediately adjacent.	Tetradecanoylphorbol Acetate	171-200	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-125
15282324-3	2004	We report here that CCND1 promoter activation by estrogens in human breast cancer cells is mediated by recruitment of a c-Jun/c-Fos/estrogen receptor alpha complex to the tetradecanoyl phorbol acetate-responsive element of the gene, together with Oct-1 to a site immediately adjacent.	Tetradecanoylphorbol Acetate	171-200	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	126-131
15138267-5	2004	Bryostatin 1 selectively prevents nPKCdelta depletion by phorbol 12-myristate 13-acetate when coapplied, coincident with protection of BCR-induced CREB phosphorylation.	Tetradecanoylphorbol Acetate	57-88	protein kinase C, delta	Mus musculus	34-43
15357004-10	2004	LY294002 a Pl3-kinase inhibitor blocked GSTA2 induction by t-BHQ, which was reversed by PMA-induced PKC activation.	Tetradecanoylphorbol Acetate	88-91	glutathione S-transferase alpha 2	Homo sapiens	40-45
15280448-3	2004	Our results demonstrate that IL-10 significantly inhibited MMP-2 transcription and protein expression induced by a phorbol ester, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	130-161	interleukin 10	Homo sapiens	29-34
15047712-8	2004	Treatment of LGI1-expressing cells with phorbol myristate acetate prevents the inhibition of MMP1/3 and restores invasiveness and ERK1/2 phosphorylation, suggesting that LGI1 acts through the ERK/MAPK pathway.	Tetradecanoylphorbol Acetate	40-65	leucine rich glioma inactivated 1	Homo sapiens	13-17
15047712-8	2004	Treatment of LGI1-expressing cells with phorbol myristate acetate prevents the inhibition of MMP1/3 and restores invasiveness and ERK1/2 phosphorylation, suggesting that LGI1 acts through the ERK/MAPK pathway.	Tetradecanoylphorbol Acetate	40-65	leucine rich glioma inactivated 1	Homo sapiens	170-174
15037634-0	2004	Activation of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, by phorbol 12-myristate 13-acetate (PMA) suppresses glucose transport into astroglioma cells via the glucose transporter-1 (GLUT-1).	Tetradecanoylphorbol Acetate	82-113	solute carrier family 2 member 1	Homo sapiens	180-201
15037634-0	2004	Activation of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, by phorbol 12-myristate 13-acetate (PMA) suppresses glucose transport into astroglioma cells via the glucose transporter-1 (GLUT-1).	Tetradecanoylphorbol Acetate	82-113	solute carrier family 2 member 1	Homo sapiens	203-209
15037634-0	2004	Activation of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, by phorbol 12-myristate 13-acetate (PMA) suppresses glucose transport into astroglioma cells via the glucose transporter-1 (GLUT-1).	Tetradecanoylphorbol Acetate	115-118	solute carrier family 2 member 1	Homo sapiens	180-201
15037634-0	2004	Activation of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, by phorbol 12-myristate 13-acetate (PMA) suppresses glucose transport into astroglioma cells via the glucose transporter-1 (GLUT-1).	Tetradecanoylphorbol Acetate	115-118	solute carrier family 2 member 1	Homo sapiens	203-209
15138488-3	2004	In this study, we found that TPA activates the c-Jun NH2-terminal kinase (JNK)/c-Jun/AP-1 pathway.	Tetradecanoylphorbol Acetate	29-32	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-52
15138488-4	2004	To explore the possible role that the JNK/c-Jun/AP-1 signal pathway has on TPA-induced apoptosis in LNCaP cells, we stably transfected the scaffold protein, JNK interacting protein 1 (JIP-1), which binds to JNK inhibiting its ability to phosphorylate c-Jun.	Tetradecanoylphorbol Acetate	75-78	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-47
15115382-4	2004	A k(app) value in the 10(3) M(-1) s(-1) range for uPA was obtained, together with a selectivity index higher than 240 toward other trypsin-like proteases such as tPA, thrombin, plasmin, and FXa.	Tetradecanoylphorbol Acetate	162-165	coagulation factor X	Homo sapiens	190-193
15102766-4	2004	Infection by L. major amastigotes blocked nuclear translocation of a phorbol-12 myristate-13 acetate (PMA)-induced p50/p65 NF-kappaB complex in PMA-treated differentiated U937 cells and triggered expression of p50- and c-Rel-containing complexes in both U937 cells and fresh human monocytes.	Tetradecanoylphorbol Acetate	69-100	REL proto-oncogene, NF-kB subunit	Homo sapiens	219-224
15102766-4	2004	Infection by L. major amastigotes blocked nuclear translocation of a phorbol-12 myristate-13 acetate (PMA)-induced p50/p65 NF-kappaB complex in PMA-treated differentiated U937 cells and triggered expression of p50- and c-Rel-containing complexes in both U937 cells and fresh human monocytes.	Tetradecanoylphorbol Acetate	102-105	REL proto-oncogene, NF-kB subunit	Homo sapiens	219-224
15086915-8	2004	In culture, hhavcr-1 is dramatically overexpressed in normal and tumor cell lines that, having acquired the fully differentiated phenotype, are induced to de-differentiate by means of phorbol ester phorbol 12-myristate-13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	198-229	hepatitis A virus cellular receptor 1	Homo sapiens	12-20
15086915-8	2004	In culture, hhavcr-1 is dramatically overexpressed in normal and tumor cell lines that, having acquired the fully differentiated phenotype, are induced to de-differentiate by means of phorbol ester phorbol 12-myristate-13-acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	231-234	hepatitis A virus cellular receptor 1	Homo sapiens	12-20
15179048-7	2004	In addition, PMA-induction of Lkn-1/CCL15 in transiently transfected U937 cells was blocked by proteasome inhibitor 1.	Tetradecanoylphorbol Acetate	13-16	C-C motif chemokine ligand 15	Homo sapiens	30-35
15179048-7	2004	In addition, PMA-induction of Lkn-1/CCL15 in transiently transfected U937 cells was blocked by proteasome inhibitor 1.	Tetradecanoylphorbol Acetate	13-16	C-C motif chemokine ligand 15	Homo sapiens	36-41
15020229-3	2004	Retinoic acid (RA)-induced differentiation increased PLD1 and PLD2 mRNA levels and PLD activity that was responsive to phorbol myristate acetate.	Tetradecanoylphorbol Acetate	119-144	phospholipase D2	Homo sapiens	62-66
15180304-7	2004	Both phorbol 12-myristate 13-acetate (PMA; 2.5 mM) and forskolin (FSK; 5 mM) increased the c-fos and c-jun mRNA expressions.	Tetradecanoylphorbol Acetate	5-36	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-96
15180304-7	2004	Both phorbol 12-myristate 13-acetate (PMA; 2.5 mM) and forskolin (FSK; 5 mM) increased the c-fos and c-jun mRNA expressions.	Tetradecanoylphorbol Acetate	5-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	101-106
15180304-7	2004	Both phorbol 12-myristate 13-acetate (PMA; 2.5 mM) and forskolin (FSK; 5 mM) increased the c-fos and c-jun mRNA expressions.	Tetradecanoylphorbol Acetate	38-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-96
15180304-7	2004	Both phorbol 12-myristate 13-acetate (PMA; 2.5 mM) and forskolin (FSK; 5 mM) increased the c-fos and c-jun mRNA expressions.	Tetradecanoylphorbol Acetate	38-41	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	101-106
15180304-9	2004	When LPS was co-treated with either PMA or FSK, it showed an additive interaction for the induction of c-jun mRNA expression.	Tetradecanoylphorbol Acetate	36-39	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-108
15059889-2	2004	Stat1, Stat3, and Stat5 were activated in mouse epidermis after treatment with different classes of tumor promoters, including 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and chrysarobin.	Tetradecanoylphorbol Acetate	127-163	signal transducer and activator of transcription 1	Mus musculus	0-5
15059889-2	2004	Stat1, Stat3, and Stat5 were activated in mouse epidermis after treatment with different classes of tumor promoters, including 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and chrysarobin.	Tetradecanoylphorbol Acetate	165-168	signal transducer and activator of transcription 1	Mus musculus	0-5
15059889-3	2004	In addition, Stat1, Stat3, and Stat5 were constitutively activated in skin tumors generated by the two-stage carcinogenesis regimen using 7,12-dimethylbenz(a)anthracene as initiator and TPA as promoter.	Tetradecanoylphorbol Acetate	186-189	signal transducer and activator of transcription 1	Mus musculus	13-18
15034932-2	2004	The natural product, nordihydroguaiaretic acid (NDGA) shows an inhibitory effect on the binding of jun/AP-1 protein to the AP-1 site in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated HL60 cells.	Tetradecanoylphorbol Acetate	136-172	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-107
15034932-2	2004	The natural product, nordihydroguaiaretic acid (NDGA) shows an inhibitory effect on the binding of jun/AP-1 protein to the AP-1 site in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated HL60 cells.	Tetradecanoylphorbol Acetate	136-172	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-127
15034932-2	2004	The natural product, nordihydroguaiaretic acid (NDGA) shows an inhibitory effect on the binding of jun/AP-1 protein to the AP-1 site in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated HL60 cells.	Tetradecanoylphorbol Acetate	174-177	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-107
15034932-2	2004	The natural product, nordihydroguaiaretic acid (NDGA) shows an inhibitory effect on the binding of jun/AP-1 protein to the AP-1 site in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated HL60 cells.	Tetradecanoylphorbol Acetate	174-177	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-127
15034932-3	2004	The NDGA inhibits the auto-regulated de novo synthesis of c-jun mRNA in TPA-stimulated HL60 cells.	Tetradecanoylphorbol Acetate	72-75	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-63
15052686-11	2004	The effects of preconditioning were mimicked by stimulating PKC with 4beta phorobol-12-myristate13-acetate (PMA).	Tetradecanoylphorbol Acetate	108-111	protein kinase C, gamma	Rattus norvegicus	60-63
15161022-3	2004	EGCG inhibited the phorbol 12-myristate 13-acetate (PMA)-induced cell invasiveness and MMP-9 expression in a dose-dependent manner.	Tetradecanoylphorbol Acetate	19-50	matrix metallopeptidase 9	Homo sapiens	87-92
15161022-3	2004	EGCG inhibited the phorbol 12-myristate 13-acetate (PMA)-induced cell invasiveness and MMP-9 expression in a dose-dependent manner.	Tetradecanoylphorbol Acetate	52-55	matrix metallopeptidase 9	Homo sapiens	87-92
15161022-7	2004	EGCG also abrogated the PMA-induced activation of extracellular-regulated protein kinase (Erk) and c-jun N-terminal kinase (JNK), which are upstream modulators of AP-1.	Tetradecanoylphorbol Acetate	24-27	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	163-167
15028639-8	2004	Pretreatment (1 h) of hippocampal cells with phorbol-12-myristate-13-acetate, a PKC activator, at increasing concentrations (1-100 ng x ml(-1)), resulted in a dose-dependent reduction in Abeta-induced toxicity, whereas the inactive 4alpha-phorbol had no effect.	Tetradecanoylphorbol Acetate	45-76	protein kinase C, gamma	Rattus norvegicus	80-83
15041541-0	2004	[Effects of mitogen-activated protein kinase on phorbol 12-myristate 13-acetate-induced matrix metalloproteinase-9 gene expression in cytotrophoblastic cells].	Tetradecanoylphorbol Acetate	48-79	matrix metallopeptidase 9	Homo sapiens	88-114
15041541-1	2004	OBJECTIVE: To explore the regulatory mechanism of matrix metalloproteinase-9 (MMP-9) gene expression induced by phorbol 12-myristate 13-acetate (PMA) in cytotrophoblastic cells.	Tetradecanoylphorbol Acetate	112-143	matrix metallopeptidase 9	Homo sapiens	50-76
15041541-1	2004	OBJECTIVE: To explore the regulatory mechanism of matrix metalloproteinase-9 (MMP-9) gene expression induced by phorbol 12-myristate 13-acetate (PMA) in cytotrophoblastic cells.	Tetradecanoylphorbol Acetate	112-143	matrix metallopeptidase 9	Homo sapiens	78-83
15041541-1	2004	OBJECTIVE: To explore the regulatory mechanism of matrix metalloproteinase-9 (MMP-9) gene expression induced by phorbol 12-myristate 13-acetate (PMA) in cytotrophoblastic cells.	Tetradecanoylphorbol Acetate	145-148	matrix metallopeptidase 9	Homo sapiens	50-76
15041541-1	2004	OBJECTIVE: To explore the regulatory mechanism of matrix metalloproteinase-9 (MMP-9) gene expression induced by phorbol 12-myristate 13-acetate (PMA) in cytotrophoblastic cells.	Tetradecanoylphorbol Acetate	145-148	matrix metallopeptidase 9	Homo sapiens	78-83
15041541-3	2004	RESULTS: Cytotrophoblastic cells treated with PMA showed markedly increased MMP-9 mRNA level.	Tetradecanoylphorbol Acetate	46-49	matrix metallopeptidase 9	Homo sapiens	76-81
14700523-10	2004	In addition, LPS/TPA induces metalloproteinase 9 (MMP9) activity by gelatin activity assay in gel.	Tetradecanoylphorbol Acetate	17-20	matrix metallopeptidase 9	Rattus norvegicus	50-54
14700523-11	2004	Wogonin and quercetin but not rutin, inhibitors of iNOS gene expression and NO production induced by LPS, showed the significant inhibition on LPS/TPA-induced transformation foci formation, accompanied by inhibiting iNOS gene expression, NO production and MMP9 activity.	Tetradecanoylphorbol Acetate	147-150	matrix metallopeptidase 9	Rattus norvegicus	256-260
14625290-4	2004	Stimulation of transfected cells with phorbol 12-myristate 13-acetate (PMA) induced metalloproteinase-mediated release of c-Kit ectodomain, which increased further upon TACE overexpression.	Tetradecanoylphorbol Acetate	38-69	ADAM metallopeptidase domain 17	Homo sapiens	169-173
14625290-4	2004	Stimulation of transfected cells with phorbol 12-myristate 13-acetate (PMA) induced metalloproteinase-mediated release of c-Kit ectodomain, which increased further upon TACE overexpression.	Tetradecanoylphorbol Acetate	71-74	ADAM metallopeptidase domain 17	Homo sapiens	169-173
14605869-6	2004	Stimulation of primary neurons with glutamate, KCl, phorbol 12-myristate 13-acetate, and leukemia inhibitory factor appreciably increased the level of c-Fos but not of Cdkl2 transcripts.	Tetradecanoylphorbol Acetate	52-83	cyclin-dependent kinase-like 2 (CDC2-related kinase)	Mus musculus	168-173
15009705-0	2004	Matrix metalloproteinase 9 expression is coordinately modulated by the KRE-M9 and 12-O-tetradecanoyl-phorbol-13-acetate responsive elements.	Tetradecanoylphorbol Acetate	82-119	matrix metallopeptidase 9	Homo sapiens	0-26
15009705-2	2004	The KRE-M9 element, which is located between the 12-O-tetradecanoyl-phorbol-13-acetate responsive element (TRE) and the transcription initiation site in the MMP-9 promoter, is essential for MMP-9 transcription in the absence of the TRE.	Tetradecanoylphorbol Acetate	49-86	matrix metallopeptidase 9	Homo sapiens	190-195
14732702-3	2004	Our data showed that the heteromeric GIRK1/GIRK4 channels were inhibited by a PKC activator phorbol 12-myristate 13-acetate (PMA) through reduction of single channel open-state probability.	Tetradecanoylphorbol Acetate	92-123	potassium inwardly rectifying channel subfamily J member 3 S homeolog	Xenopus laevis	37-42
14732702-3	2004	Our data showed that the heteromeric GIRK1/GIRK4 channels were inhibited by a PKC activator phorbol 12-myristate 13-acetate (PMA) through reduction of single channel open-state probability.	Tetradecanoylphorbol Acetate	125-128	potassium inwardly rectifying channel subfamily J member 3 S homeolog	Xenopus laevis	37-42
15193278-8	2004	Supporting this idea, the cytosolic and particulate protein levels of PKC delta and were found to change with time, and may account for the time-dependent manner in which TPA induced cell death.	Tetradecanoylphorbol Acetate	171-174	protein kinase C, gamma	Rattus norvegicus	70-73
14693697-3	2004	In contrast, responses to the pharmacologic activator 12-O-tetradecanoylphorbol-13-acetate (TPA) were reciprocally modulated by overexpression of the PKC alpha WT or PKC alpha KD but not the corresponding PKC delta adenoviruses.	Tetradecanoylphorbol Acetate	54-90	protein kinase C, alpha	Rattus norvegicus	150-159
14693697-3	2004	In contrast, responses to the pharmacologic activator 12-O-tetradecanoylphorbol-13-acetate (TPA) were reciprocally modulated by overexpression of the PKC alpha WT or PKC alpha KD but not the corresponding PKC delta adenoviruses.	Tetradecanoylphorbol Acetate	54-90	protein kinase C, alpha	Rattus norvegicus	166-175
15136882-5	2004	Treatment of NPVSM with 10 nM 4-beta phorbol myristate acetate (PMA), a PKC activator, induced translocation of PKCalpha, and PKCdelta from the soluble to the particulate fraction, while exposure to 10 nM endothelin-1 (ET-1), a potent vasoconstrictor and mitogenic substance, caused translocation of PKCdelta and PKCiota from the soluble to the particulate fraction.	Tetradecanoylphorbol Acetate	64-67	protein kinase C, alpha	Rattus norvegicus	72-75
14673171-4	2004	We report here that ATF-3, JunB, and BRG-1 (the ATPase subunit of the 2-MDa human chromatin remodeling machine SWI/SNF) are recruited to the 3" boundary of nuc-1 following phorbol myristate acetate stimulation in Jurkat T cells.	Tetradecanoylphorbol Acetate	172-197	peroxisome proliferator activated receptor delta	Homo sapiens	156-161
14670086-4	2003	We manipulated the response to PMA using a potent synthetic agonist of PPARdelta , compound F. THP-1 sub-lines that either over-expressed PPARdelta protein, or expressed PPARdelta anti-sense RNA were generated.	Tetradecanoylphorbol Acetate	31-34	peroxisome proliferator activated receptor delta	Homo sapiens	71-80
12880635-7	2003	TNF expression was upregulated in PBLs, and in G14D and 42TA cells, but not in 3B11 cells, by PMA/calcium ionophore treatment.	Tetradecanoylphorbol Acetate	94-97	tumor necrosis factor a (TNF superfamily, member 2)	Ictalurus punctatus	0-3
14672351-0	2003	12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation.	Tetradecanoylphorbol Acetate	0-36	TNF superfamily member 11	Homo sapiens	86-91
14672351-0	2003	12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation.	Tetradecanoylphorbol Acetate	38-41	TNF superfamily member 11	Homo sapiens	86-91
14672351-2	2003	Using a RAW(264.7) cell culture system and assays for NF-kappaB nuclear translocation, NF-kappaB reporter gene activity, and MAPK assays, we demonstrated that TPA inhibits osteoclastogenesis through the suppression of RANKL-induced NF-kappaB activation.	Tetradecanoylphorbol Acetate	159-162	TNF superfamily member 11	Homo sapiens	218-223
14672351-7	2003	Assays for NF-kappaB nuclear translocation, NF-kappaB reporter gene activity, protein kinase activity, and Western blotting were used to examine the effects of TPA on RANKL-induced NF-kappaB, c-Jun N-terminal kinase (JNK), and MEK/ERK and p38 signal transduction pathways.	Tetradecanoylphorbol Acetate	160-163	TNF superfamily member 11	Homo sapiens	167-172
14672351-8	2003	RESULTS: We found that TPA inhibited RANKL-induced RAW(264.7) cell differentiation into osteoclasts in a dose-dependent manner.	Tetradecanoylphorbol Acetate	23-26	TNF superfamily member 11	Homo sapiens	37-42
14672351-9	2003	Time course analysis showed that the inhibitory effect of TPA on RANKL-induced osteoclastogenesis occurs predominantly at an early stage of osteoclast differentiation.	Tetradecanoylphorbol Acetate	58-61	TNF superfamily member 11	Homo sapiens	65-70
14672351-10	2003	TPA alone had little effect on NF-kappaB activation in RAW(264.7) cells, but it suppresses the RANKL-induced NF-kappaB activation in a dose-dependent fashion.	Tetradecanoylphorbol Acetate	0-3	TNF superfamily member 11	Homo sapiens	95-100
14672351-11	2003	Interestingly, the suppressive effect of TPA on RANKL-induced NF-kappaB activation was prevented by a conventional PKC inhibitor, Go6976.	Tetradecanoylphorbol Acetate	41-44	TNF superfamily member 11	Homo sapiens	48-53
14672351-14	2003	TPA also inhibited RANKL-induced activation of ERK but had little effect on p38 activation.	Tetradecanoylphorbol Acetate	0-3	TNF superfamily member 11	Homo sapiens	19-24
14672351-15	2003	CONCLUSION: Given that NF-kappaB activation is obligatory for osteoclast differentiation, our studies imply that inhibition of osteoclastogenesis by TPA is, at least in part, caused by the suppression of RANKL-induced activation of NF-kappaB during an early stage of osteoclastogenesis.	Tetradecanoylphorbol Acetate	149-152	TNF superfamily member 11	Homo sapiens	204-209
12628505-5	2003	Pretreatment of dorsal skins of female ICR mice with Rg(3) significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase activity and 7,12-dimethylbenz[a]anthracene-initiated papilloma formation.	Tetradecanoylphorbol Acetate	83-119	ornithine decarboxylase, structural 1	Mus musculus	134-157
12433930-2	2003	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is often used to induce AP-1 activity.	Tetradecanoylphorbol Acetate	18-54	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	85-89
12433930-2	2003	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is often used to induce AP-1 activity.	Tetradecanoylphorbol Acetate	56-59	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	85-89
12433930-8	2003	We demonstrated that c-Fos, c-Jun, and JunD are involved in TPA inhibitory effect due to their ability to bind TRE-ALAS, evidenced by supershift analysis and their capacity to repress promoter activity in transfection assays.	Tetradecanoylphorbol Acetate	60-63	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-26
12433930-8	2003	We demonstrated that c-Fos, c-Jun, and JunD are involved in TPA inhibitory effect due to their ability to bind TRE-ALAS, evidenced by supershift analysis and their capacity to repress promoter activity in transfection assays.	Tetradecanoylphorbol Acetate	60-63	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-33
14680506-9	2003	Interestingly, macrophages stimulated with phorbol 12-myristate 13-acetate/ionomycin displayed an augmented IL-10 response upon addition of dibutyryl cAMP, with corresponding downregulation in TNF-alpha, suggesting a complex interaction between protein kinase C and protein kinase A in cytokine regulation.	Tetradecanoylphorbol Acetate	43-74	interleukin 10	Homo sapiens	108-113
12457964-6	2002	Kinetic studies of antigen expression by Western blotting revealed that ORF50 protein was induced as early as 6 h after TPA treatment.	Tetradecanoylphorbol Acetate	120-123	ORF50	Human gammaherpesvirus 8	72-77
12207561-3	2002	In contrast with previous studies, a hyperphosphorylated form of this PKC isoform, promoted by calyculin A, was rapidly degraded in PMA-treated cells.	Tetradecanoylphorbol Acetate	132-135	protein kinase C, delta	Mus musculus	70-73
12414091-5	2002	Here we showed that a relatively low concentration of 12-phorbol-13-myristate acetate (PMA) mimicked the EtOH-caused inhibition of MBP expression without affecting morphology.	Tetradecanoylphorbol Acetate	87-90	myelin basic protein	Rattus norvegicus	131-134
12213812-5	2002	Protein kinase C (PKC) activators, the diacylglycerol analogue 1,2-dioctanoyl-sn-glycerol and phorbol myristate acetate (PMA), mimicked the effect of serotonin on MMP-13 protein expression; prolonged PMA treatment (which down-regulates PKC) lowered MMP-13 protein levels.	Tetradecanoylphorbol Acetate	94-119	matrix metallopeptidase 13	Rattus norvegicus	163-169
12213812-5	2002	Protein kinase C (PKC) activators, the diacylglycerol analogue 1,2-dioctanoyl-sn-glycerol and phorbol myristate acetate (PMA), mimicked the effect of serotonin on MMP-13 protein expression; prolonged PMA treatment (which down-regulates PKC) lowered MMP-13 protein levels.	Tetradecanoylphorbol Acetate	94-119	matrix metallopeptidase 13	Rattus norvegicus	249-255
12384259-10	2002	Phorbol 12-myristate 13-acetate, a PKC activator, inhibited the activity of both wild type and Y403H EAAT2.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, gamma	Rattus norvegicus	35-38
12947046-5	2003	In addition, we demonstrated that the E2 repression could be antagonized by phorbol 12-myristate 13-acetate, which stimulated c-Jun phosphorylation on serine 63, a process that is a prerequisite for recruitment of the transcriptional coactivator cAMP response element binding protein (CREB)-binding protein (CBP).	Tetradecanoylphorbol Acetate	76-107	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	126-131
34737182-5	2021	Patients who received mechanical thrombectomy alone were compared with those who underwent MT+IV-tPA.	Tetradecanoylphorbol Acetate	97-100	metallothionein 4	Homo sapiens	91-96
34650643-12	2021	In a 12-O-tetradecanoylphorbol-13-acetate-induced mouse model, Tat-Trx1 reduced inflammatory damage by inhibiting inflammatory mediator and cytokine production.	Tetradecanoylphorbol Acetate	5-41	thioredoxin 1	Mus musculus	67-71
34608498-8	2021	Furthermore, downregulation of matriptase suppressed TPA-induced MMP-9 expression and invasiveness via PAR-2/PLCgamma2/PKC/MAPK activation.	Tetradecanoylphorbol Acetate	53-56	matrix metallopeptidase 9	Homo sapiens	65-70
12379230-4	2002	Here we documented that 15d-PGJ(2) dose-dependently inhibited phorbol-12-myristate-13-acetate (PMA)-stimulated expression of the PDGF-A and PDGF-B chain in human umbilical vein endothelial cells (HUVEC) by Northern blot and Western blot analyses.	Tetradecanoylphorbol Acetate	62-93	platelet derived growth factor subunit A	Homo sapiens	129-135
12379230-4	2002	Here we documented that 15d-PGJ(2) dose-dependently inhibited phorbol-12-myristate-13-acetate (PMA)-stimulated expression of the PDGF-A and PDGF-B chain in human umbilical vein endothelial cells (HUVEC) by Northern blot and Western blot analyses.	Tetradecanoylphorbol Acetate	62-93	platelet derived growth factor subunit B	Homo sapiens	140-146
34899697-7	2021	They also decreased IL-17+ T and NKT cells following PMA and Ionomycin-stimulation.	Tetradecanoylphorbol Acetate	53-56	interleukin 17A	Homo sapiens	20-25
12379230-4	2002	Here we documented that 15d-PGJ(2) dose-dependently inhibited phorbol-12-myristate-13-acetate (PMA)-stimulated expression of the PDGF-A and PDGF-B chain in human umbilical vein endothelial cells (HUVEC) by Northern blot and Western blot analyses.	Tetradecanoylphorbol Acetate	95-98	platelet derived growth factor subunit A	Homo sapiens	129-135
12379230-4	2002	Here we documented that 15d-PGJ(2) dose-dependently inhibited phorbol-12-myristate-13-acetate (PMA)-stimulated expression of the PDGF-A and PDGF-B chain in human umbilical vein endothelial cells (HUVEC) by Northern blot and Western blot analyses.	Tetradecanoylphorbol Acetate	95-98	platelet derived growth factor subunit B	Homo sapiens	140-146
12296855-4	2002	The effect of blockade of Kor is to inhibit phorbol myristate acetate (PMA)-induced cytokine production by translational or post-translational mechanisms, an effect that is duplicated by increasing extracellular K+.	Tetradecanoylphorbol Acetate	44-69	opioid receptor kappa 1	Homo sapiens	26-29
12296855-4	2002	The effect of blockade of Kor is to inhibit phorbol myristate acetate (PMA)-induced cytokine production by translational or post-translational mechanisms, an effect that is duplicated by increasing extracellular K+.	Tetradecanoylphorbol Acetate	71-74	opioid receptor kappa 1	Homo sapiens	26-29
34808347-8	2022	Furthermore, we demonstrated that HIV-1-infected cells that underwent the transient expression of FLIP- or XIAP-induced viral latency would then produce an increased level of viral RNA upon the reversal of these antiapoptotic effects via PMA treatment compared to LacZ control cells.	Tetradecanoylphorbol Acetate	238-241	X-linked inhibitor of apoptosis	Homo sapiens	107-111
12356734-4	2002	Using a CARD-deleted variant of CARD11 and RNA interference (RNAi), we demonstrate that CARD11 mediates NF-kappaB activation by alphaCD3/alphaCD28 cross-linking and PMA/ionomycin treatment, but not by TNFalpha or dsRNA.	Tetradecanoylphorbol Acetate	165-168	caspase recruitment domain family, member 11	Mus musculus	32-38
12356734-4	2002	Using a CARD-deleted variant of CARD11 and RNA interference (RNAi), we demonstrate that CARD11 mediates NF-kappaB activation by alphaCD3/alphaCD28 cross-linking and PMA/ionomycin treatment, but not by TNFalpha or dsRNA.	Tetradecanoylphorbol Acetate	165-168	caspase recruitment domain family, member 11	Mus musculus	88-94
12209884-3	2002	TPA-induced mitogen activated protein kinases (MAPK) phosphorylation, ornithine decarboxylase (ODC), c-Jun, and cyclooxygenase 2 (COX-2) protein expressions in a time-dependent manner, and the maximal inductive time point is at 1 h for MAPK phosphorylation and 6 h for others.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	70-93
34867961-9	2021	In stimulating peripheral blood mononuclear cells using PMA plus ionomycin, a high TIM3 level on T cells correlated with low interleukin-2 and tumor necrosis factor-alpha (TNF-alpha) on CD4+ cells and interferon-gamma and TNF-alpha on CD8+ T cells.	Tetradecanoylphorbol Acetate	56-59	hepatitis A virus cellular receptor 2	Homo sapiens	83-87
12209884-3	2002	TPA-induced mitogen activated protein kinases (MAPK) phosphorylation, ornithine decarboxylase (ODC), c-Jun, and cyclooxygenase 2 (COX-2) protein expressions in a time-dependent manner, and the maximal inductive time point is at 1 h for MAPK phosphorylation and 6 h for others.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	95-98
12209884-4	2002	Flavanone, 2"-OH flavanone, 4"-OH flavanone, 6-OH flavanone showed the dose-dependent inhibition on TPA-stimulated MAPK phosphorylation, COX-2, ODC, c-Jun protein expressions.	Tetradecanoylphorbol Acetate	100-103	ornithine decarboxylase, structural 1	Mus musculus	144-147
12209884-7	2002	And, PD98059, a specific inhibitor of ERKs, inhibited TPA-induced MAPK phosphorylation, accompanied by decreasing COX-2, c-Jun, and ODC protein expression, and showed dose-dependent inhibition on TPA-induced proliferation in cells.	Tetradecanoylphorbol Acetate	54-57	ornithine decarboxylase, structural 1	Mus musculus	132-135
12209884-8	2002	These results demonstrated that PGE(2) is an important mediator in TPA-induced proliferation, and MAPK phosphorylation was located at the upstream of COX-2, c-Jun, and ODC gene expressions in TPA-induced responses.	Tetradecanoylphorbol Acetate	192-195	ornithine decarboxylase, structural 1	Mus musculus	168-171
12209884-9	2002	Furthermore, flavanone, 2"-OH flavanone, 4"-OH flavanone, 6-OH flavanone (100 microM) suppressed TPA-induced colony formation associated with blocking MAPK phosphorylation, ODC, c-Jun, and COX-2 proteins expression.	Tetradecanoylphorbol Acetate	97-100	ornithine decarboxylase, structural 1	Mus musculus	173-176
34867961-9	2021	In stimulating peripheral blood mononuclear cells using PMA plus ionomycin, a high TIM3 level on T cells correlated with low interleukin-2 and tumor necrosis factor-alpha (TNF-alpha) on CD4+ cells and interferon-gamma and TNF-alpha on CD8+ T cells.	Tetradecanoylphorbol Acetate	56-59	CD8a molecule	Homo sapiens	235-238
34769032-0	2021	Fluoroquinolones Suppress TGF-beta and PMA-Induced MMP-9 Production in Cancer Cells: Implications in Repurposing Quinolone Antibiotics for Cancer Treatment.	Tetradecanoylphorbol Acetate	39-42	matrix metallopeptidase 9	Homo sapiens	51-56
12244166-2	2002	Using stable Jurkat transfectants that express KIR or CD8-KIR fusion proteins we have shown for the first time that KIR inhibits, in a ligation-independent manner, the AICD induced by PHA, PMA/ionomycin, or anti-CD3 Ab.	Tetradecanoylphorbol Acetate	189-192	CD8a molecule	Homo sapiens	54-57
12244166-2	2002	Using stable Jurkat transfectants that express KIR or CD8-KIR fusion proteins we have shown for the first time that KIR inhibits, in a ligation-independent manner, the AICD induced by PHA, PMA/ionomycin, or anti-CD3 Ab.	Tetradecanoylphorbol Acetate	189-192	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	58-61
12244166-2	2002	Using stable Jurkat transfectants that express KIR or CD8-KIR fusion proteins we have shown for the first time that KIR inhibits, in a ligation-independent manner, the AICD induced by PHA, PMA/ionomycin, or anti-CD3 Ab.	Tetradecanoylphorbol Acetate	189-192	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	58-61
12193414-4	2002	Provision of granulosa cells with phorbol 12-myristate 13-acetate (PMA) (but not 4alphaPMA, an inert analogue), a tumor-promoting phorbol ester and an established activator of PKC, was without significant effect on the expression of IGFBP-4 transcripts but resulted in biphasic dose-dependent alterations in IGFBP-5 transcripts and in the accumulation of the IGFBP-4 and -5 proteins.	Tetradecanoylphorbol Acetate	67-70	protein kinase C, gamma	Rattus norvegicus	176-179
34672321-5	2022	Contrary to those results, we show here that tumor development induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) together with DMBA was suppressed in DNAM-1-deficient mice.	Tetradecanoylphorbol Acetate	74-110	CD226 antigen	Mus musculus	154-160
34672321-5	2022	Contrary to those results, we show here that tumor development induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) together with DMBA was suppressed in DNAM-1-deficient mice.	Tetradecanoylphorbol Acetate	112-115	CD226 antigen	Mus musculus	154-160
34667224-0	2021	K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors.	Tetradecanoylphorbol Acetate	118-121	keratin 15	Mus musculus	0-3
12208511-2	2002	We found that in a dose-dependent manner soluble CD163 induces a decrease in CD69 expression, a reduced [(3)H]thymidine uptake and a down-regulated matrix metalloproteinase-9 RNA expression in phorbol myristate acetate-stimulated T-cells.	Tetradecanoylphorbol Acetate	193-218	CD163 molecule	Homo sapiens	49-54
12208511-2	2002	We found that in a dose-dependent manner soluble CD163 induces a decrease in CD69 expression, a reduced [(3)H]thymidine uptake and a down-regulated matrix metalloproteinase-9 RNA expression in phorbol myristate acetate-stimulated T-cells.	Tetradecanoylphorbol Acetate	193-218	matrix metallopeptidase 9	Homo sapiens	148-174
34667224-6	2021	However, K15 promoter-driven expression of NKIRAS2 effectively suppressed the development of skin tumors induced by treatment with 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	169-205	keratin 15	Mus musculus	9-12
12187329-6	2002	Whereas TPA treatment resulted in a strong induction of p21(WAF/CIP1), c-Fos and c-Jun levels, neither one of the novel PKC activators altered expression of these proteins.	Tetradecanoylphorbol Acetate	8-11	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-76
12187329-6	2002	Whereas TPA treatment resulted in a strong induction of p21(WAF/CIP1), c-Fos and c-Jun levels, neither one of the novel PKC activators altered expression of these proteins.	Tetradecanoylphorbol Acetate	8-11	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	81-86
34667224-6	2021	However, K15 promoter-driven expression of NKIRAS2 effectively suppressed the development of skin tumors induced by treatment with 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	169-205	NFKB inhibitor interacting Ras-like protein 2	Mus musculus	43-50
12118064-1	2002	Downregulation of protein kinase Calpha (PKCalpha) following long-term exposure to phorbol esters such as TPA is traffic dependent and involves delivery of the active, membrane-associated PKCalpha to endosomes.	Tetradecanoylphorbol Acetate	106-109	protein kinase C, alpha	Rattus norvegicus	18-39
34667224-6	2021	However, K15 promoter-driven expression of NKIRAS2 effectively suppressed the development of skin tumors induced by treatment with 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	207-210	keratin 15	Mus musculus	9-12
12118064-1	2002	Downregulation of protein kinase Calpha (PKCalpha) following long-term exposure to phorbol esters such as TPA is traffic dependent and involves delivery of the active, membrane-associated PKCalpha to endosomes.	Tetradecanoylphorbol Acetate	106-109	protein kinase C, alpha	Rattus norvegicus	41-49
34667224-6	2021	However, K15 promoter-driven expression of NKIRAS2 effectively suppressed the development of skin tumors induced by treatment with 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	207-210	NFKB inhibitor interacting Ras-like protein 2	Mus musculus	43-50
12118064-1	2002	Downregulation of protein kinase Calpha (PKCalpha) following long-term exposure to phorbol esters such as TPA is traffic dependent and involves delivery of the active, membrane-associated PKCalpha to endosomes.	Tetradecanoylphorbol Acetate	106-109	protein kinase C, alpha	Rattus norvegicus	188-196
12118064-2	2002	In this study, we show that synaptotagmin II (Syt II), a member of the Syt family of proteins, is required for TPA-induced degradation of PKCalpha.	Tetradecanoylphorbol Acetate	111-114	protein kinase C, alpha	Rattus norvegicus	138-146
34437989-11	2021	These data suggest that PMA treatment induces IL1beta and TNF-alpha release and modulation of TNFRI/TNFRII expression promoting RGCs survival after axotomy.	Tetradecanoylphorbol Acetate	24-27	TNF receptor superfamily member 1A	Rattus norvegicus	94-99
12118064-4	2002	We demonstrate that in TPA-treated RBL cells, PKCalpha travels from the cytosol to the plasma membrane, where it is delivered to early endosomes on its route to degradation.	Tetradecanoylphorbol Acetate	23-26	protein kinase C, alpha	Rattus norvegicus	46-54
12118064-5	2002	By contrast, in TPA-treated RBL-Syt II(-) cells, PKCalpha is diverted to recycling endosomes and remains distributed between the plasma membrane and the perinuclear recycling endocytic compartment.	Tetradecanoylphorbol Acetate	16-19	protein kinase C, alpha	Rattus norvegicus	49-57
34721397-7	2021	We found that CD29 could be reliably used as a marker to identify CD4+ CTLs in rhesus macaques since CD29hi CD4+ T cells secrete higher cytotoxic and proinflammatory cytokines following PMA/ionomycin or gag stimulation.	Tetradecanoylphorbol Acetate	186-189	CD4 molecule	Macaca mulatta	66-69
12190877-5	2002	Ultraviolet (30 mJ per cm2) and phorbol ester (12-O-tetradecanoyl-phorbol-13-acetate, 50 nM) treatment increased expression of human macrophage metalloelastase mRNA and protein in the cultured human dermal fibroblasts, but not in the keratinocytes.	Tetradecanoylphorbol Acetate	47-84	matrix metallopeptidase 12	Homo sapiens	133-159
34721397-7	2021	We found that CD29 could be reliably used as a marker to identify CD4+ CTLs in rhesus macaques since CD29hi CD4+ T cells secrete higher cytotoxic and proinflammatory cytokines following PMA/ionomycin or gag stimulation.	Tetradecanoylphorbol Acetate	186-189	CD4 molecule	Macaca mulatta	108-111
34645720-8	2022	After stimulation with 10 nM or 1 muM TPA, ANXA1 and A5 mRNA levels were increased at 6 h. ANXA1 mRNA levels were higher in the 1 muM TPA than in the 10 nM TPA treatment, whereas 1 muM TPA did not show further stimulation of ANXA5 mRNA compared to 10 nM TPA.	Tetradecanoylphorbol Acetate	38-41	annexin A5	Mus musculus	225-230
12101411-3	2002	The induction of a specific subset of AP-1 responsive genes thought to be important for tumour development, namely GM-CSF, MMP-9 and MMP-3, was suppressed in TNF-alpha(-/-) compared to wild-type mouse skin in response to the tumour promotor TPA.	Tetradecanoylphorbol Acetate	241-244	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	115-121
34157522-3	2021	This study was designed to analyze the effect of tPA therapy on interleukin-38 serum level changes and the serum level of IL-38 in the prognosis of ischemic stroke patients in the next three months.	Tetradecanoylphorbol Acetate	49-52	interleukin 1 family member 10	Homo sapiens	64-78
12080017-8	2002	PKC alpha translocation was first detected 5-10 min after exposure to TPA and reached a maximum at 20 min, whereas in eggs activated by OAG, translocation of PKC alpha was observed almost immediately and reached a maximum within 5 min.	Tetradecanoylphorbol Acetate	70-73	protein kinase C, alpha	Rattus norvegicus	0-9
34157522-3	2021	This study was designed to analyze the effect of tPA therapy on interleukin-38 serum level changes and the serum level of IL-38 in the prognosis of ischemic stroke patients in the next three months.	Tetradecanoylphorbol Acetate	49-52	interleukin 1 family member 10	Homo sapiens	122-127
11955957-3	2002	The PKC activator phorbol 12-myristate 13-acetate (PMA) inhibited the lysosomal degradation of [14C]S-HRP (1 microM PMA: 40% inhibition, P&lt;.05), without affecting either the endocytic uptake or the delivery to lysosomes.	Tetradecanoylphorbol Acetate	18-49	protein kinase C, gamma	Rattus norvegicus	4-7
34339541-0	2021	A novel melatonin-regulated lncRNA suppresses TPA-induced oral cancer cell motility through replenishing PRUNE2 expression.	Tetradecanoylphorbol Acetate	46-49	prune homolog 2 with BCH domain	Homo sapiens	105-111
11955957-3	2002	The PKC activator phorbol 12-myristate 13-acetate (PMA) inhibited the lysosomal degradation of [14C]S-HRP (1 microM PMA: 40% inhibition, P&lt;.05), without affecting either the endocytic uptake or the delivery to lysosomes.	Tetradecanoylphorbol Acetate	51-54	protein kinase C, gamma	Rattus norvegicus	4-7
14642775-4	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema, in which the expression of sPLA(2)-IID, -IIF and -V was increased, was significantly reduced by YM-26734, a competitive sPLA(2)-IIA inhibitor that turned out to inhibit sPLA(2)-IID, -IIE, -V and -X as well.	Tetradecanoylphorbol Acetate	0-36	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	95-119
14642775-4	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema, in which the expression of sPLA(2)-IID, -IIF and -V was increased, was significantly reduced by YM-26734, a competitive sPLA(2)-IIA inhibitor that turned out to inhibit sPLA(2)-IID, -IIE, -V and -X as well.	Tetradecanoylphorbol Acetate	0-36	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	188-199
14642775-4	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema, in which the expression of sPLA(2)-IID, -IIF and -V was increased, was significantly reduced by YM-26734, a competitive sPLA(2)-IIA inhibitor that turned out to inhibit sPLA(2)-IID, -IIE, -V and -X as well.	Tetradecanoylphorbol Acetate	0-36	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	95-102
14642775-4	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema, in which the expression of sPLA(2)-IID, -IIF and -V was increased, was significantly reduced by YM-26734, a competitive sPLA(2)-IIA inhibitor that turned out to inhibit sPLA(2)-IID, -IIE, -V and -X as well.	Tetradecanoylphorbol Acetate	38-41	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	95-119
14642775-4	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema, in which the expression of sPLA(2)-IID, -IIF and -V was increased, was significantly reduced by YM-26734, a competitive sPLA(2)-IIA inhibitor that turned out to inhibit sPLA(2)-IID, -IIE, -V and -X as well.	Tetradecanoylphorbol Acetate	38-41	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	188-199
14642775-4	2003	12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema, in which the expression of sPLA(2)-IID, -IIF and -V was increased, was significantly reduced by YM-26734, a competitive sPLA(2)-IIA inhibitor that turned out to inhibit sPLA(2)-IID, -IIE, -V and -X as well.	Tetradecanoylphorbol Acetate	38-41	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	95-102
11955957-3	2002	The PKC activator phorbol 12-myristate 13-acetate (PMA) inhibited the lysosomal degradation of [14C]S-HRP (1 microM PMA: 40% inhibition, P&lt;.05), without affecting either the endocytic uptake or the delivery to lysosomes.	Tetradecanoylphorbol Acetate	116-119	protein kinase C, gamma	Rattus norvegicus	4-7
11955957-7	2002	PMA induced phosphorylation and hepatocyte membrane-to-lysosome redistribution of the myristoylated alanine-rich C kinase substrate (MARCKS) protein, raising the possibility that MARCKS mediates the PKC-induced inhibition of lysosomal proteolysis.	Tetradecanoylphorbol Acetate	0-3	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	86-131
11955957-7	2002	PMA induced phosphorylation and hepatocyte membrane-to-lysosome redistribution of the myristoylated alanine-rich C kinase substrate (MARCKS) protein, raising the possibility that MARCKS mediates the PKC-induced inhibition of lysosomal proteolysis.	Tetradecanoylphorbol Acetate	0-3	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	133-139
34339541-3	2021	Downregulation of MROS-1 by melatonin suppressed TPA-induced oral cancer migration through replenishing the protein expression of prune homolog 2 (PRUNE2), which functioned as a tumor suppressor in oral cancer.	Tetradecanoylphorbol Acetate	49-52	prune homolog 2 with BCH domain	Homo sapiens	130-145
11955957-7	2002	PMA induced phosphorylation and hepatocyte membrane-to-lysosome redistribution of the myristoylated alanine-rich C kinase substrate (MARCKS) protein, raising the possibility that MARCKS mediates the PKC-induced inhibition of lysosomal proteolysis.	Tetradecanoylphorbol Acetate	0-3	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	179-185
34339541-3	2021	Downregulation of MROS-1 by melatonin suppressed TPA-induced oral cancer migration through replenishing the protein expression of prune homolog 2 (PRUNE2), which functioned as a tumor suppressor in oral cancer.	Tetradecanoylphorbol Acetate	49-52	prune homolog 2 with BCH domain	Homo sapiens	147-153
11955957-7	2002	PMA induced phosphorylation and hepatocyte membrane-to-lysosome redistribution of the myristoylated alanine-rich C kinase substrate (MARCKS) protein, raising the possibility that MARCKS mediates the PKC-induced inhibition of lysosomal proteolysis.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, gamma	Rattus norvegicus	199-202
12960044-8	2003	In contrast, 12-O-tetradecanoyl phorbol-13-acetate, a protein kinase C (PKC) activator, increased Phex expression in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	13-50	phosphate regulating endopeptidase homolog, X-linked	Rattus norvegicus	98-102
34421897-7	2021	Flow cytometry suggested that the Y287N mutation might reduce the expression of IL-17 of Th17 cells in peripheral blood mononuclear cells stimulated by phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	152-177	interleukin 17A	Homo sapiens	80-85
12127822-3	2002	To mimic the effects of IPC, adenosine (ADO; an adenosine receptor agonist) or 4-phorbol 12-myristate 13-acetate (PMA; a PKC activator) was delivered to the vascular network of the cremaster 24 h before the prolonged ischemia via local intra-arterial infusion.	Tetradecanoylphorbol Acetate	114-117	protein kinase C, gamma	Rattus norvegicus	121-124
34440679-9	2021	Flagellin, PMA and poly I:C exerted proinflammatory action in certain concentrations in both 2D and 3D cultures, reflected by the increased cellular IL-6 release.	Tetradecanoylphorbol Acetate	11-14	interleukin 6	Gallus gallus	149-153
12134072-3	2002	In normal NIH 3T3 cells, (Raf-1[51-220]GFP) showed minimal membrane localization that was enhanced after stimulation with platelet-derived growth factor or phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	156-187	v-raf-leukemia viral oncogene 1	Mus musculus	26-31
12071806-7	2002	We performed a molecular analysis of Hras gene mutations in skin tumors of Car-S mice induced by X-ray initiation/TPA promotion or by TPA promotion alone.	Tetradecanoylphorbol Acetate	114-117	Harvey rat sarcoma virus oncogene	Mus musculus	37-41
15088714-4	2003	Glutamate transport was decreased significantly in Muller cells exposed to phorbol-12-myristate-13-acetate (PMA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	75-106	protein kinase C, gamma	Rattus norvegicus	116-132
15088714-4	2003	Glutamate transport was decreased significantly in Muller cells exposed to phorbol-12-myristate-13-acetate (PMA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	75-106	protein kinase C, gamma	Rattus norvegicus	134-137
15088714-4	2003	Glutamate transport was decreased significantly in Muller cells exposed to phorbol-12-myristate-13-acetate (PMA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	108-111	protein kinase C, gamma	Rattus norvegicus	116-132
15088714-4	2003	Glutamate transport was decreased significantly in Muller cells exposed to phorbol-12-myristate-13-acetate (PMA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	108-111	protein kinase C, gamma	Rattus norvegicus	134-137
12941954-9	2003	We identified tumor necrosis factor alpha-converting enzyme (TACE or ADAM17) as the protease that mediates the PMA-induced release.	Tetradecanoylphorbol Acetate	111-114	ADAM metallopeptidase domain 17	Homo sapiens	61-65
12941954-9	2003	We identified tumor necrosis factor alpha-converting enzyme (TACE or ADAM17) as the protease that mediates the PMA-induced release.	Tetradecanoylphorbol Acetate	111-114	ADAM metallopeptidase domain 17	Homo sapiens	69-75
12071806-7	2002	We performed a molecular analysis of Hras gene mutations in skin tumors of Car-S mice induced by X-ray initiation/TPA promotion or by TPA promotion alone.	Tetradecanoylphorbol Acetate	134-137	Harvey rat sarcoma virus oncogene	Mus musculus	37-41
34307446-7	2021	Observer-independent high-content imaging revealed a striking reduction of perinuclear Weibel-Palade bodies in unstimulated CCM1 -/- BOECs which was observed in CCM1 +/- BOECs only after stimulation with PMA or histamine.	Tetradecanoylphorbol Acetate	204-207	KRIT1 ankyrin repeat containing	Homo sapiens	161-165
11956220-3	2002	In this study, we have shown that phorbol 12-myristate 13-acetate (PMA) increases human MAO B, but not MAO A, gene expression.	Tetradecanoylphorbol Acetate	34-65	monoamine oxidase B	Homo sapiens	88-93
11956220-3	2002	In this study, we have shown that phorbol 12-myristate 13-acetate (PMA) increases human MAO B, but not MAO A, gene expression.	Tetradecanoylphorbol Acetate	67-70	monoamine oxidase B	Homo sapiens	88-93
11956220-9	2002	Furthermore, protein kinase C inhibitor blocks the PMA-dependent activation of MAO B.	Tetradecanoylphorbol Acetate	51-54	monoamine oxidase B	Homo sapiens	79-84
11956220-10	2002	Co-transfection of the MAO B promoter with dominant negative forms of Ras, Raf-1, MEKK1, MEK1, MEK3, MEK7, ERK2, JNK1, and p38/RK inhibit the PMA-dependent activation of the MAO B promoter.	Tetradecanoylphorbol Acetate	142-145	monoamine oxidase B	Homo sapiens	23-28
12191496-3	2002	Here we report that secretion and expression of HGF in U87 astrocytoma is increased by a PKC activator, PMA, an effect which is abolished by a PKC inhibitor, Go6976, specific for PKCalpha and PKCbeta1.	Tetradecanoylphorbol Acetate	104-107	small nucleolar RNA, C/D box 87	Homo sapiens	55-58
12057991-7	2002	CREB-2 and c-Fos binding was increased by phorbol 12-myristate 13-acetate but not tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	42-73	activating transcription factor 2	Homo sapiens	0-6
12057991-7	2002	CREB-2 and c-Fos binding was increased by phorbol 12-myristate 13-acetate but not tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	42-73	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	11-16
12119277-4	2002	For example, treatment with cholera toxin, thapsigargin, and phorbol 12-myristate 13-acetate (which activate PKA, CaM kinase II, and PKC, respectively) exhibit synergy in the stimulation of both PLD and secretion.	Tetradecanoylphorbol Acetate	61-92	protein kinase C, gamma	Rattus norvegicus	133-136
12093473-5	2002	The zymosan-induced increase in iPLA2 activity was suppressed by pretreatment with 4beta-phorbol 12-myristate 13-acetate for 10 hr, by which PKCalpha and PKCdelta, but not PKCbeta and PKCepsilon, were depleted, and by Go6976, a PKCalpha inhibitor, but not rottlerin, a PKCdelta inhibitor.	Tetradecanoylphorbol Acetate	83-120	protein kinase C, delta	Mus musculus	154-162
12093473-5	2002	The zymosan-induced increase in iPLA2 activity was suppressed by pretreatment with 4beta-phorbol 12-myristate 13-acetate for 10 hr, by which PKCalpha and PKCdelta, but not PKCbeta and PKCepsilon, were depleted, and by Go6976, a PKCalpha inhibitor, but not rottlerin, a PKCdelta inhibitor.	Tetradecanoylphorbol Acetate	83-120	protein kinase C, delta	Mus musculus	269-277
12113473-9	2002	Considering the TPA-responsiveness and expression pattern, we propose that KLF5 like another member of its family KLF4/GKLF may play an important role in skin morphogenesis and carcinogenesis potentially via its interaction with NF-kappaB factors.	Tetradecanoylphorbol Acetate	16-19	Kruppel like factor 4	Homo sapiens	114-118
12113473-9	2002	Considering the TPA-responsiveness and expression pattern, we propose that KLF5 like another member of its family KLF4/GKLF may play an important role in skin morphogenesis and carcinogenesis potentially via its interaction with NF-kappaB factors.	Tetradecanoylphorbol Acetate	16-19	Kruppel like factor 4	Homo sapiens	119-123
12032864-2	2002	We reported that FVB/N transgenic mice that overexpress ( approximately eightfold) PKCdelta protein in basal epidermal cells are resistant to skin tumor formation by the 7,12-dimethylbenz(a)anthracene (DMBA)-initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promotion protocol.	Tetradecanoylphorbol Acetate	223-259	protein kinase C, delta	Mus musculus	83-91
12032864-2	2002	We reported that FVB/N transgenic mice that overexpress ( approximately eightfold) PKCdelta protein in basal epidermal cells are resistant to skin tumor formation by the 7,12-dimethylbenz(a)anthracene (DMBA)-initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promotion protocol.	Tetradecanoylphorbol Acetate	261-264	protein kinase C, delta	Mus musculus	83-91
12032864-3	2002	However, despite being resistant to skin tumor promotion by TPA, PKCdelta transgenic mice elicited a 3-4-fold increase in TPA-induced epidermal ODC activity and putrescine levels than their wild-type littermates.	Tetradecanoylphorbol Acetate	122-125	protein kinase C, delta	Mus musculus	65-73
12032864-3	2002	However, despite being resistant to skin tumor promotion by TPA, PKCdelta transgenic mice elicited a 3-4-fold increase in TPA-induced epidermal ODC activity and putrescine levels than their wild-type littermates.	Tetradecanoylphorbol Acetate	122-125	ornithine decarboxylase, structural 1	Mus musculus	144-147
12032864-4	2002	PKCdelta was observed to be the key component of the TPA signal transduction pathways to the induction of mouse epidermal ODC activity.	Tetradecanoylphorbol Acetate	53-56	protein kinase C, delta	Mus musculus	0-8
12032864-4	2002	PKCdelta was observed to be the key component of the TPA signal transduction pathways to the induction of mouse epidermal ODC activity.	Tetradecanoylphorbol Acetate	53-56	ornithine decarboxylase, structural 1	Mus musculus	122-125
12032864-5	2002	To determine if TPA-induced ODC activity and associated putrescine levels in PKCdelta transgenic mice contributed to PKCdelta-mediated suppression of skin tumor promotion by TPA, the irreversible inhibitor of ODC, alpha-difluoromethylornithine (DFMO), was used.	Tetradecanoylphorbol Acetate	16-19	ornithine decarboxylase, structural 1	Mus musculus	28-31
11986211-3	2002	In the presence of serum and phorbol 12-myristate 13-acetate (PMA), a PKC activator, cells exhibited full megakaryocytic differentiation, manifested by adhesion, shape change, increased cell size, polyploidy, PPF, and expression of CD41(+), CD61(+), and CD62P(+).	Tetradecanoylphorbol Acetate	29-60	integrin subunit alpha 2b	Homo sapiens	232-236
11986211-3	2002	In the presence of serum and phorbol 12-myristate 13-acetate (PMA), a PKC activator, cells exhibited full megakaryocytic differentiation, manifested by adhesion, shape change, increased cell size, polyploidy, PPF, and expression of CD41(+), CD61(+), and CD62P(+).	Tetradecanoylphorbol Acetate	62-65	integrin subunit alpha 2b	Homo sapiens	232-236
12082627-5	2002	The AP-1 activator phorbol 12-myristate 13-acetate (TPA) enhanced the binding of this DR4 AP-1 binding site to protein(s) in a nuclear extract from TPA-treated cells, increased luciferase activity of a reporter construct containing this site and induced DR4 expression at the transcription level.	Tetradecanoylphorbol Acetate	52-55	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-8
12082627-5	2002	The AP-1 activator phorbol 12-myristate 13-acetate (TPA) enhanced the binding of this DR4 AP-1 binding site to protein(s) in a nuclear extract from TPA-treated cells, increased luciferase activity of a reporter construct containing this site and induced DR4 expression at the transcription level.	Tetradecanoylphorbol Acetate	52-55	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-94
12082627-5	2002	The AP-1 activator phorbol 12-myristate 13-acetate (TPA) enhanced the binding of this DR4 AP-1 binding site to protein(s) in a nuclear extract from TPA-treated cells, increased luciferase activity of a reporter construct containing this site and induced DR4 expression at the transcription level.	Tetradecanoylphorbol Acetate	148-151	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-8
12082627-5	2002	The AP-1 activator phorbol 12-myristate 13-acetate (TPA) enhanced the binding of this DR4 AP-1 binding site to protein(s) in a nuclear extract from TPA-treated cells, increased luciferase activity of a reporter construct containing this site and induced DR4 expression at the transcription level.	Tetradecanoylphorbol Acetate	148-151	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-94
12020816-4	2002	The TPA-induced differentiation of U937 cells, which also resulted in growth arrest, abruptly down-regulated the expression of NHP2.	Tetradecanoylphorbol Acetate	4-7	NHP2 ribonucleoprotein	Homo sapiens	127-131
12020816-5	2002	Removal of TPA restored cell growth through the retrodifferentiation process and subsequent expression of NHP2.	Tetradecanoylphorbol Acetate	11-14	NHP2 ribonucleoprotein	Homo sapiens	106-110
11947929-6	2002	These results suggest that intracellular signals initiated by alpha4beta7 integrin involve the tyrosine phosphorylation of paxillin and p105(Cas-L), which are differentially regulated, at least in part, by mechanisms that are PMA-sensitive or -insensitive.	Tetradecanoylphorbol Acetate	226-229	neural precursor cell expressed, developmentally down-regulated gene 9	Mus musculus	136-140
11947929-6	2002	These results suggest that intracellular signals initiated by alpha4beta7 integrin involve the tyrosine phosphorylation of paxillin and p105(Cas-L), which are differentially regulated, at least in part, by mechanisms that are PMA-sensitive or -insensitive.	Tetradecanoylphorbol Acetate	226-229	neural precursor cell expressed, developmentally down-regulated gene 9	Mus musculus	141-146
11956069-5	2002	The subsequent confirmation of the altered expression levels of the selected genes by semiquantitative reverse transcription-PCR demonstrated that overexpression of the antisense ING1 stimulated expression of 14 genes, which included cyclin B1, 12-O-tetradecanoylphorbol-13-acetate-inducible sequence 11, proto-oncogene DEK, and osteopontin, whereas we have detected transcriptional repression of 5 genes, including TPT1.	Tetradecanoylphorbol Acetate	245-281	inhibitor of growth family, member 1	Mus musculus	179-183
11956069-6	2002	In addition, adenovirus-mediated overexpression of ING1 in NMuMG cells resulted in down-regulation of cyclin B1, 12-O-tetradecanoylphorbol-13-acetate-inducible sequence 11, DEK, and osteopontin, whereas the levels of TPT1 expression were increased.	Tetradecanoylphorbol Acetate	113-149	inhibitor of growth family, member 1	Mus musculus	51-55
11897696-3	2002	In whole cell lysates, proteasome inhibitors (proteasome inhibitor I and II, Lactacystin, beta-Lactone, Calpain inhibitor I) prevented in both gonadotrope cell lines the TPA-induced depletion of PKC alpha, epsilon, and the GnRH-elicited PKC epsilon down-regulation; they counteracted in mixed pituitary cell cultures as well, the TPA-evoked PKC alpha, epsilon depletion.	Tetradecanoylphorbol Acetate	170-173	protein kinase C, alpha	Rattus norvegicus	195-204
11897696-3	2002	In whole cell lysates, proteasome inhibitors (proteasome inhibitor I and II, Lactacystin, beta-Lactone, Calpain inhibitor I) prevented in both gonadotrope cell lines the TPA-induced depletion of PKC alpha, epsilon, and the GnRH-elicited PKC epsilon down-regulation; they counteracted in mixed pituitary cell cultures as well, the TPA-evoked PKC alpha, epsilon depletion.	Tetradecanoylphorbol Acetate	170-173	protein kinase C, alpha	Rattus norvegicus	341-350
11897696-7	2002	Inhibition of PKC catalytic activity (GF109203X, Go6976), selectively prevented the TPA-evoked PKC alpha depletion in both mixed pituitary cells and alpha T(3)-1 gonadotropes; in alpha T(3)-1 subcellular fractions, PKC alpha inactivation overcame the TPA-evoked isoenzyme degradation by inducing a pronounced membrane accumulation of the isoform without affecting its membrane relocalization.	Tetradecanoylphorbol Acetate	84-87	protein kinase C, alpha	Rattus norvegicus	14-17
11897696-7	2002	Inhibition of PKC catalytic activity (GF109203X, Go6976), selectively prevented the TPA-evoked PKC alpha depletion in both mixed pituitary cells and alpha T(3)-1 gonadotropes; in alpha T(3)-1 subcellular fractions, PKC alpha inactivation overcame the TPA-evoked isoenzyme degradation by inducing a pronounced membrane accumulation of the isoform without affecting its membrane relocalization.	Tetradecanoylphorbol Acetate	84-87	protein kinase C, alpha	Rattus norvegicus	95-104
11897696-7	2002	Inhibition of PKC catalytic activity (GF109203X, Go6976), selectively prevented the TPA-evoked PKC alpha depletion in both mixed pituitary cells and alpha T(3)-1 gonadotropes; in alpha T(3)-1 subcellular fractions, PKC alpha inactivation overcame the TPA-evoked isoenzyme degradation by inducing a pronounced membrane accumulation of the isoform without affecting its membrane relocalization.	Tetradecanoylphorbol Acetate	84-87	protein kinase C, alpha	Rattus norvegicus	215-224
11897696-7	2002	Inhibition of PKC catalytic activity (GF109203X, Go6976), selectively prevented the TPA-evoked PKC alpha depletion in both mixed pituitary cells and alpha T(3)-1 gonadotropes; in alpha T(3)-1 subcellular fractions, PKC alpha inactivation overcame the TPA-evoked isoenzyme degradation by inducing a pronounced membrane accumulation of the isoform without affecting its membrane relocalization.	Tetradecanoylphorbol Acetate	251-254	protein kinase C, alpha	Rattus norvegicus	14-17
12042071-9	2002	Okadaic acid and phorbol 12-myristate 13-acetate significantly decreased heme-mediated induction of heme oxygenase-1 mRNA in both Huh-7 and HepG2 cells.	Tetradecanoylphorbol Acetate	17-48	MIR7-3 host gene	Homo sapiens	130-135
11927660-9	2002	fMetLeuPhe and phorbol 12-myristate 13-acetate stimulated ARNO and cytohesin-1 as well as Arf1 translocation to HL-60 cell membranes.	Tetradecanoylphorbol Acetate	15-46	ADP ribosylation factor 1	Homo sapiens	90-94
12054913-5	2002	IL-17 also enhanced the IL-6 synthesis stimulated by 12- O -tetradecanoylphorbol-13-acetate, a direct activator of protein kinase C. In addition, IL-17 amplified the IL-6 synthesis induced by ET-1.	Tetradecanoylphorbol Acetate	53-91	interleukin 17A	Mus musculus	0-5
12054913-5	2002	IL-17 also enhanced the IL-6 synthesis stimulated by 12- O -tetradecanoylphorbol-13-acetate, a direct activator of protein kinase C. In addition, IL-17 amplified the IL-6 synthesis induced by ET-1.	Tetradecanoylphorbol Acetate	53-91	interleukin 17A	Mus musculus	146-151
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, alpha	Rattus norvegicus	49-58
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, alpha	Rattus norvegicus	264-273
11888895-2	2002	However, our recent reports indicated that 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced tumor development is suppressed in Jnk2 knockout mice but enhanced in Jnk1 knockout mice.	Tetradecanoylphorbol Acetate	74-110	mitogen-activated protein kinase 8	Mus musculus	189-193
11888903-4	2002	Here, we show that JNK1-deficient (Jnk1(-/-)) mice are more susceptible to TPA-induced skin tumor development than wild-type mice.	Tetradecanoylphorbol Acetate	75-78	mitogen-activated protein kinase 8	Mus musculus	35-39
11888903-6	2002	At the end of 33 weeks of TPA promotion, the number of skin tumors and tumors &gt;1.5 mm in diameter per mouse in Jnk1(-/-) mice was significantly increased by 71% (P &lt; 0.03) and 82% (P &lt; 0.03), respectively, relative to the wild-type mice.	Tetradecanoylphorbol Acetate	26-29	mitogen-activated protein kinase 8	Mus musculus	114-118
11888903-8	2002	Strikingly, Jnk1(-/-) mouse skin was more sensitive to TPA-induced AP-1 DNA binding activity and phosphorylation of extracellular signal-regulated kinases and Akt, which are two important survival signaling components.	Tetradecanoylphorbol Acetate	55-58	mitogen-activated protein kinase 8	Mus musculus	12-16
11896487-7	2002	RESULTS: PMA (200 nM) induced maximal translocation of ventricular PKCalpha from the cytosol to the membranes within 10 min.	Tetradecanoylphorbol Acetate	9-12	protein kinase C, alpha	Rattus norvegicus	67-75
11751911-7	2002	ICAM-1 promoter activity was enhanced by IFN-gamma and TPA in cells transfected with pIC339-Luc, containing the downstream NF-kappaB and gamma-activated site (GAS) sites, but not in cells transfected with GAS-deletion mutant, pIC135 (DeltaAP2).	Tetradecanoylphorbol Acetate	55-58	intercellular adhesion molecule 1	Homo sapiens	0-6
11751911-9	2002	The IFN-gamma-induced ICAM-1 promoter activity was inhibited by tyrosine kinase inhibitors, a phosphatidylinositol-phospholipase C inhibitor, or PKC inhibitors, and the TPA-induced ICAM-1 promoter activity was also inhibited by tyrosine kinase inhibitors.	Tetradecanoylphorbol Acetate	169-172	intercellular adhesion molecule 1	Homo sapiens	22-28
11751911-11	2002	However, cotransfection with dominant negative mutants of PKCalpha or c-Src inhibited both IFN-gamma- and TPA-induced ICAM-1 promoter activity.	Tetradecanoylphorbol Acetate	106-109	intercellular adhesion molecule 1	Homo sapiens	118-124
11922944-6	2002	Expression of mSSP increased significantly within the first hours of B cell treatment with either CD40L, anti-IgM, or phorbol myristate acetate (PMA) with or without ionomycin.	Tetradecanoylphorbol Acetate	118-143	NOP58 ribonucleoprotein	Mus musculus	14-18
11853160-0	2002	Induction of CD4+ regulatory T cells by TPA in mice: contra-suppression by CD8+ T cells.	Tetradecanoylphorbol Acetate	40-43	CD4 antigen	Mus musculus	13-16
11853160-1	2002	Among the eight inbred mouse strains employed in our preceding report, 12-O-tetradecanoylphorbol 13-acetate (TPA) painting alone induced CD4+ regulatory T (Tr) cells in four strains (e.g., C3H/He) at 6-8 weeks of age, but not in the remaining strains (e.g., C57BL/6, BALB/c).	Tetradecanoylphorbol Acetate	71-107	CD4 antigen	Mus musculus	137-140
11853160-1	2002	Among the eight inbred mouse strains employed in our preceding report, 12-O-tetradecanoylphorbol 13-acetate (TPA) painting alone induced CD4+ regulatory T (Tr) cells in four strains (e.g., C3H/He) at 6-8 weeks of age, but not in the remaining strains (e.g., C57BL/6, BALB/c).	Tetradecanoylphorbol Acetate	109-112	CD4 antigen	Mus musculus	137-140
11853160-8	2002	ICAM-1 expression on CD4 T cells greatly increased following growth in 10 week-BALB/c mice receiving TPA than 6-week-old mice, however, a slight increase in growth occurred in 6-to-10-week-old animals in which TPA was absent.	Tetradecanoylphorbol Acetate	101-104	CD4 antigen	Mus musculus	21-24
11853160-8	2002	ICAM-1 expression on CD4 T cells greatly increased following growth in 10 week-BALB/c mice receiving TPA than 6-week-old mice, however, a slight increase in growth occurred in 6-to-10-week-old animals in which TPA was absent.	Tetradecanoylphorbol Acetate	210-213	CD4 antigen	Mus musculus	21-24
11853175-6	2002	And it also suppressed ornithine decarboxylase activity stimulated by TPA on mouse skin.	Tetradecanoylphorbol Acetate	70-73	ornithine decarboxylase, structural 1	Mus musculus	23-46
11875714-0	2002	Interferon-alpha resistance in renal carcinoma cells is associated with defective induction of signal transducer and activator of transcription 1 which can be restored by a supernatant of phorbol 12-myristate 13-acetate stimulated peripheral blood mononuclear cells.	Tetradecanoylphorbol Acetate	188-219	signal transducer and activator of transcription 1	Homo sapiens	95-145
11875714-3	2002	Here we report both, a lack of signal transducer and activator of transcription induction in interferon-alpha resistant renal cell carcinoma cells and signal transducer and activator of transcription 1 reinduction of phorbol 12-myristate 13-acetate-stimulated peripheral blood mononuclear cells supernatant.	Tetradecanoylphorbol Acetate	217-248	signal transducer and activator of transcription 1	Homo sapiens	151-201
11876774-3	2002	32P-labelling of GluR4 increased upon AMPA receptor stimulation or cell treatment with phorbol 12-myristate 13-acetate (PMA) before stimulating with kainate.	Tetradecanoylphorbol Acetate	87-118	glutamate ionotropic receptor AMPA type subunit 4	Gallus gallus	17-22
11876774-3	2002	32P-labelling of GluR4 increased upon AMPA receptor stimulation or cell treatment with phorbol 12-myristate 13-acetate (PMA) before stimulating with kainate.	Tetradecanoylphorbol Acetate	120-123	glutamate ionotropic receptor AMPA type subunit 4	Gallus gallus	17-22
14519120-0	2003	PKCdelta-dependent cleavage and nuclear translocation of annexin A1 by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	71-102	annexin A1	Homo sapiens	57-67
14519120-2	2003	The mitogen phorbol 12-myristate 13-acetate (PMA) induces expression and phosphorylation of ANX-1.	Tetradecanoylphorbol Acetate	12-43	annexin A1	Homo sapiens	92-97
14519120-2	2003	The mitogen phorbol 12-myristate 13-acetate (PMA) induces expression and phosphorylation of ANX-1.	Tetradecanoylphorbol Acetate	45-48	annexin A1	Homo sapiens	92-97
14519120-6	2003	The PMA-induced nuclear translocation of ANX-1 was inhibited by the protein kinase C (PKC)delta-specific inhibitor rottlerin, indicating that PKCdelta plays a role in nuclear translocation of the cleaved ANX-1.	Tetradecanoylphorbol Acetate	4-7	annexin A1	Homo sapiens	41-46
14519120-6	2003	The PMA-induced nuclear translocation of ANX-1 was inhibited by the protein kinase C (PKC)delta-specific inhibitor rottlerin, indicating that PKCdelta plays a role in nuclear translocation of the cleaved ANX-1.	Tetradecanoylphorbol Acetate	4-7	annexin A1	Homo sapiens	204-209
12960243-4	2003	Immunoprecipitation experiments using plasma membranes of phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils revealed coimmunoprecipitation of PR3 with CD11b/CD18, indicating their location in the same complex.	Tetradecanoylphorbol Acetate	91-94	integrin subunit alpha M	Homo sapiens	162-167
14585180-6	2003	In a second experiment, two groups each consisting of three CD(1) mice were used to assess the effect of pomegranate seed oil on TPA-stimulated ornithine decarboxylase (ODC) activity, an important event in skin cancer promotion.	Tetradecanoylphorbol Acetate	129-132	ornithine decarboxylase, structural 1	Mus musculus	169-172
14585180-10	2003	Pomegranate seed oil (5%) significantly decreased (P &lt;.05) tumor incidence, multiplicity, and TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	97-100	ornithine decarboxylase, structural 1	Mus musculus	109-112
14585196-0	2003	Proteasome-mediated degradation of RNase L in response to phorbol-12-myristate-13-acetate (PMA) treatment of mouse L929 cells.	Tetradecanoylphorbol Acetate	58-89	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	Mus musculus	35-42
14585196-0	2003	Proteasome-mediated degradation of RNase L in response to phorbol-12-myristate-13-acetate (PMA) treatment of mouse L929 cells.	Tetradecanoylphorbol Acetate	91-94	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	Mus musculus	35-42
14585196-3	2003	Here, we report that phorbol-12-myristate-13-acetate (PMA) treatment of mouse L929 fibroblasts caused rapid degradation of RNase L in a dose-dependent and time-dependent manner.	Tetradecanoylphorbol Acetate	21-52	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	Mus musculus	123-130
14585196-3	2003	Here, we report that phorbol-12-myristate-13-acetate (PMA) treatment of mouse L929 fibroblasts caused rapid degradation of RNase L in a dose-dependent and time-dependent manner.	Tetradecanoylphorbol Acetate	54-57	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	Mus musculus	123-130
12869588-4	2003	IRES-mediated translation was potentiated by the protein kinase C activators, 12-O-tetradecanoylphorbol 13-acetate (PMA) and bryostatin 1, and appears to involve phosphorylation of amino terminus of eIF4G.	Tetradecanoylphorbol Acetate	116-119	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	199-204
12954456-3	2003	Among the various monosaccharides (1 mM) tested in the presence of PMA, myo-inositol was most effective in restoring the PMA-induced down-regulation of taurine transport in murine macrophages (82% increase compared to the value for cells treated with PMA Alone, p &lt; 0.01).	Tetradecanoylphorbol Acetate	67-70	synaptopodin 2	Mus musculus	72-75
12954456-3	2003	Among the various monosaccharides (1 mM) tested in the presence of PMA, myo-inositol was most effective in restoring the PMA-induced down-regulation of taurine transport in murine macrophages (82% increase compared to the value for cells treated with PMA Alone, p &lt; 0.01).	Tetradecanoylphorbol Acetate	121-124	synaptopodin 2	Mus musculus	72-75
12954456-3	2003	Among the various monosaccharides (1 mM) tested in the presence of PMA, myo-inositol was most effective in restoring the PMA-induced down-regulation of taurine transport in murine macrophages (82% increase compared to the value for cells treated with PMA Alone, p &lt; 0.01).	Tetradecanoylphorbol Acetate	121-124	synaptopodin 2	Mus musculus	72-75
12972643-4	2003	To examine this hypothesis, we stimulated NCI-H292 cells with phorbol 12-myristate 13-acetate (PMA, an activator of TACE) and pathophysiologic stimuli [lipopolysaccharide (LPS) and supernatant from the Gram-negative bacterium Pseudomonas aeruginosa (PA sup)].	Tetradecanoylphorbol Acetate	95-98	ADAM metallopeptidase domain 17	Homo sapiens	116-120
12826681-2	2003	Several authors have described how 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of cells results in an increase of Src activity, but the mechanism of the PKC-mediated Src activation is unknown.	Tetradecanoylphorbol Acetate	35-71	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	125-128
12826681-2	2003	Several authors have described how 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of cells results in an increase of Src activity, but the mechanism of the PKC-mediated Src activation is unknown.	Tetradecanoylphorbol Acetate	73-76	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	125-128
12826681-2	2003	Several authors have described how 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of cells results in an increase of Src activity, but the mechanism of the PKC-mediated Src activation is unknown.	Tetradecanoylphorbol Acetate	73-76	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	177-180
12826681-8	2003	These data support a model in which the main mechanism of 12-O-tetradecanoylphorbol-13-acetate-induced Src activation is the direct phosphorylation and activation of PTP alpha by PKC delta, which in turn dephosphorylates and activates Src.	Tetradecanoylphorbol Acetate	58-94	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	103-106
12826681-8	2003	These data support a model in which the main mechanism of 12-O-tetradecanoylphorbol-13-acetate-induced Src activation is the direct phosphorylation and activation of PTP alpha by PKC delta, which in turn dephosphorylates and activates Src.	Tetradecanoylphorbol Acetate	58-94	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	235-238
12967943-4	2003	(2) The monocytic cell line U-937 strongly expresses Annexin 1 after 24 h of phorbol 12-myristate 13-acetate (PMA, 1 nm) treatment and externalizes/releases the protein after additional 16 h of dexamethasone (1 microm) treatment.	Tetradecanoylphorbol Acetate	77-108	annexin A1	Homo sapiens	53-62
12967943-4	2003	(2) The monocytic cell line U-937 strongly expresses Annexin 1 after 24 h of phorbol 12-myristate 13-acetate (PMA, 1 nm) treatment and externalizes/releases the protein after additional 16 h of dexamethasone (1 microm) treatment.	Tetradecanoylphorbol Acetate	110-113	annexin A1	Homo sapiens	53-62
12938167-1	2003	We have investigated the effects of sex steroids, estradiol (E2), and testosterone (T) on the synthesis of tumor necrosis factor alpha (TNF-alpha) and interleukin-10 (IL-10) in phorbol-myristate-acetate (PMA)-differentiated human monoblastic U937 cells.	Tetradecanoylphorbol Acetate	177-202	interleukin 10	Homo sapiens	151-165
12938167-1	2003	We have investigated the effects of sex steroids, estradiol (E2), and testosterone (T) on the synthesis of tumor necrosis factor alpha (TNF-alpha) and interleukin-10 (IL-10) in phorbol-myristate-acetate (PMA)-differentiated human monoblastic U937 cells.	Tetradecanoylphorbol Acetate	177-202	interleukin 10	Homo sapiens	167-172
12925217-7	2003	Histamine enhanced transcriptional activity and DNA binding of activator protein 1 at the two TPA-response elements.	Tetradecanoylphorbol Acetate	94-97	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-82
12925217-8	2003	It shifted the TPA-response-element-binding activator protein 1 composition from c-Jun homodimers to c-Fos/c-Jun heterodimers.	Tetradecanoylphorbol Acetate	15-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	44-63
12925217-8	2003	It shifted the TPA-response-element-binding activator protein 1 composition from c-Jun homodimers to c-Fos/c-Jun heterodimers.	Tetradecanoylphorbol Acetate	15-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	81-86
12925217-8	2003	It shifted the TPA-response-element-binding activator protein 1 composition from c-Jun homodimers to c-Fos/c-Jun heterodimers.	Tetradecanoylphorbol Acetate	15-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	101-106
12925217-8	2003	It shifted the TPA-response-element-binding activator protein 1 composition from c-Jun homodimers to c-Fos/c-Jun heterodimers.	Tetradecanoylphorbol Acetate	15-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-112
12970875-0	2003	Degradation of retinoid X receptor alpha by TPA through proteasome pathway in gastric cancer cells.	Tetradecanoylphorbol Acetate	44-47	retinoid X receptor alpha	Homo sapiens	15-40
12970875-1	2003	AIM: To investigate and determine the mechanism and signal pathway of tetradecanoylphorbol-1, 3-acetate (TPA) in degradation of RXRalpha.	Tetradecanoylphorbol Acetate	105-108	retinoid X receptor alpha	Homo sapiens	128-136
12970875-8	2003	When cells were treated with TPA, expression of RXRalpha was repressed in a time-dependent and TPA-concentration-dependent manner.	Tetradecanoylphorbol Acetate	29-32	retinoid X receptor alpha	Homo sapiens	48-56
12970875-8	2003	When cells were treated with TPA, expression of RXRalpha was repressed in a time-dependent and TPA-concentration-dependent manner.	Tetradecanoylphorbol Acetate	95-98	retinoid X receptor alpha	Homo sapiens	48-56
12970875-10	2003	When cells were pre-incubated with proteasome inhibitor MG132 for 3 hrs, followed by TPA for another 12 hrs, TPA-induced RXRalpha degradation was inhibited.	Tetradecanoylphorbol Acetate	85-88	retinoid X receptor alpha	Homo sapiens	121-129
12970875-10	2003	When cells were pre-incubated with proteasome inhibitor MG132 for 3 hrs, followed by TPA for another 12 hrs, TPA-induced RXRalpha degradation was inhibited.	Tetradecanoylphorbol Acetate	109-112	retinoid X receptor alpha	Homo sapiens	121-129
12970875-11	2003	Further observation of RXRalpha translocation in the presence of MG132 showed that MG-132 could block TPA-induced RXRalpha redistribution.	Tetradecanoylphorbol Acetate	102-105	retinoid X receptor alpha	Homo sapiens	23-31
12970875-11	2003	Further observation of RXRalpha translocation in the presence of MG132 showed that MG-132 could block TPA-induced RXRalpha redistribution.	Tetradecanoylphorbol Acetate	102-105	retinoid X receptor alpha	Homo sapiens	114-122
12970875-12	2003	Conversely, when RXRalpha translocation was inhibited by LMB, an inhibitor for blocking protein export from the nucleus, TPA could not repress expression of RXRalpha.	Tetradecanoylphorbol Acetate	121-124	retinoid X receptor alpha	Homo sapiens	17-25
12970875-13	2003	CONCLUSION: TPA could induce the degradation of RXRalpha protein in BGC-823 cells, and this degradation is time- and TPA-concentration-dependent.	Tetradecanoylphorbol Acetate	12-15	retinoid X receptor alpha	Homo sapiens	48-56
12970875-13	2003	CONCLUSION: TPA could induce the degradation of RXRalpha protein in BGC-823 cells, and this degradation is time- and TPA-concentration-dependent.	Tetradecanoylphorbol Acetate	117-120	retinoid X receptor alpha	Homo sapiens	48-56
12970875-14	2003	Furthermore, the degradation of RXRalpha by TPA is via a proteasome pathway and associated with RXRalphatranslocation from the nucleus to the cytoplasm.	Tetradecanoylphorbol Acetate	44-47	retinoid X receptor alpha	Homo sapiens	32-40
12795636-11	2003	Furthermore, we have detected a dramatic increase in immune staining of EOS in cultured U937 cells treated with PMA, which represent activated macrophages.	Tetradecanoylphorbol Acetate	112-115	EOS	Homo sapiens	72-75
12890570-5	2003	Since activities of CRE-luc and c-fos-luc were highly dependent on cell types, GnRH-induced CRE-luc or c-fos-luc activity was normalized by forskolin-induced CRE-luc or 12-O-tetradecanoylphenol-13-acetate (TPA)-induced c-fos-luc activity, respectively.	Tetradecanoylphorbol Acetate	206-209	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-108
12890570-5	2003	Since activities of CRE-luc and c-fos-luc were highly dependent on cell types, GnRH-induced CRE-luc or c-fos-luc activity was normalized by forskolin-induced CRE-luc or 12-O-tetradecanoylphenol-13-acetate (TPA)-induced c-fos-luc activity, respectively.	Tetradecanoylphorbol Acetate	206-209	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-108
12928540-4	2003	Tacalcitol ointment (20 micro g/g) also significantly inhibited TPA-induced myeloperoxidase (MPO) activity, as effectively as calcipotriol ointment (50 micro g/g) or betamethasone valerate ointment (1.2 mg/g).	Tetradecanoylphorbol Acetate	64-67	myeloperoxidase	Mus musculus	76-91
12928540-4	2003	Tacalcitol ointment (20 micro g/g) also significantly inhibited TPA-induced myeloperoxidase (MPO) activity, as effectively as calcipotriol ointment (50 micro g/g) or betamethasone valerate ointment (1.2 mg/g).	Tetradecanoylphorbol Acetate	64-67	myeloperoxidase	Mus musculus	93-96
12774311-6	2003	Moreover, this effect was attenuated by the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate, which can rapidly decrease AQP4 mRNA expression, indicating that the response was specific.	Tetradecanoylphorbol Acetate	71-107	aquaporin 4	Homo sapiens	136-140
12787135-6	2003	GC-rich Sp1 element and activator protein 1 (AP-1) element on MCP-1 promoter were required for constitutive and 12-O-tetradecanoylphorbol-13-acetate-induced transcription, respectively, and involved in transrepression by E2.	Tetradecanoylphorbol Acetate	112-148	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	24-43
12787135-6	2003	GC-rich Sp1 element and activator protein 1 (AP-1) element on MCP-1 promoter were required for constitutive and 12-O-tetradecanoylphorbol-13-acetate-induced transcription, respectively, and involved in transrepression by E2.	Tetradecanoylphorbol Acetate	112-148	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-49
12787135-7	2003	E2 inhibited constitutive Sp1 and 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 transcriptional activities whereas it did not inhibit DNA binding of Sp1 or AP-1 c-Fos/c-Jun.	Tetradecanoylphorbol Acetate	34-70	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-83
12787062-8	2003	Stimulation of TH gene promoter activity, which was observed in control cell lines treated with either 50 mm KCl or TPA was also dramatically inhibited in the c-Fos-deficient cells.	Tetradecanoylphorbol Acetate	116-119	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	159-164
12790799-5	2003	To further investigate whether conventional or novel PKC isoforms adversely affect beta-cell proliferation, the effect of phorbol ester (phorbol 12-myristate 13-acetate; PMA)-mediated activation of these PKC isoforms on glucose/IGF-I-induced INS-1 cell mitogenesis, and insulin receptor substrate (IRS)-mediated signal transduction was investigated.	Tetradecanoylphorbol Acetate	137-168	protein kinase C, gamma	Rattus norvegicus	204-207
12790799-5	2003	To further investigate whether conventional or novel PKC isoforms adversely affect beta-cell proliferation, the effect of phorbol ester (phorbol 12-myristate 13-acetate; PMA)-mediated activation of these PKC isoforms on glucose/IGF-I-induced INS-1 cell mitogenesis, and insulin receptor substrate (IRS)-mediated signal transduction was investigated.	Tetradecanoylphorbol Acetate	170-173	protein kinase C, gamma	Rattus norvegicus	204-207
12790799-6	2003	PMA-mediated activation of PKC (100 nM; 4 h) reduced glucose/IGF-I mediated beta-cell mitogenesis (&gt;50%; P&lt; or =0.05), which was reversible by the general PKC inhibitor Go6850 (1 microM), indicating an effect of PKC and not due to a non-specific PMA toxicity.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, gamma	Rattus norvegicus	27-30
12790799-6	2003	PMA-mediated activation of PKC (100 nM; 4 h) reduced glucose/IGF-I mediated beta-cell mitogenesis (&gt;50%; P&lt; or =0.05), which was reversible by the general PKC inhibitor Go6850 (1 microM), indicating an effect of PKC and not due to a non-specific PMA toxicity.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, gamma	Rattus norvegicus	161-164
12790799-6	2003	PMA-mediated activation of PKC (100 nM; 4 h) reduced glucose/IGF-I mediated beta-cell mitogenesis (&gt;50%; P&lt; or =0.05), which was reversible by the general PKC inhibitor Go6850 (1 microM), indicating an effect of PKC and not due to a non-specific PMA toxicity.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, gamma	Rattus norvegicus	161-164
12790799-10	2003	Thus, FFA/PMA-induced activation of novel PKC isoforms can inhibit glucose/IGF-I-mediated beta-cell mitogenesis, in part by decreasing PKB activation, despite an upregulation of Erk1/2.	Tetradecanoylphorbol Acetate	10-13	protein kinase C, gamma	Rattus norvegicus	42-45
12745093-2	2003	We found that phorbol-12-myristate-13-acetate (PMA)-stimulated invasion of the hepatocellular carcinoma (HCC) SNU-387 and SNU-398 cells and that PMA induced the secretion of MMP-9 in the cells, but did not induce the secretion of MMP-2.	Tetradecanoylphorbol Acetate	14-45	matrix metallopeptidase 9	Homo sapiens	174-179
12745093-2	2003	We found that phorbol-12-myristate-13-acetate (PMA)-stimulated invasion of the hepatocellular carcinoma (HCC) SNU-387 and SNU-398 cells and that PMA induced the secretion of MMP-9 in the cells, but did not induce the secretion of MMP-2.	Tetradecanoylphorbol Acetate	47-50	matrix metallopeptidase 9	Homo sapiens	174-179
12621058-6	2003	This protein, which we named SPRACT, is derived through alternative translation of the TACE-coding sequence and is, similarly to TACE, phosphorylated in response to growth factor and phorbol 12-myristate 13-acetate stimulation.	Tetradecanoylphorbol Acetate	183-214	ADAM metallopeptidase domain 17	Homo sapiens	87-91
12621058-6	2003	This protein, which we named SPRACT, is derived through alternative translation of the TACE-coding sequence and is, similarly to TACE, phosphorylated in response to growth factor and phorbol 12-myristate 13-acetate stimulation.	Tetradecanoylphorbol Acetate	183-214	ADAM metallopeptidase domain 17	Homo sapiens	129-133
12615924-4	2003	In this study we investigate the molecular mechanism for PKC regulation of ROMK and report that mutants of ROMK1 with reduced PIP(2) affinity exhibit an increased sensitivity to inhibition by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	192-217	potassium inwardly rectifying channel subfamily J member 1 S homeolog	Xenopus laevis	75-79
12615924-4	2003	In this study we investigate the molecular mechanism for PKC regulation of ROMK and report that mutants of ROMK1 with reduced PIP(2) affinity exhibit an increased sensitivity to inhibition by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	192-217	potassium inwardly rectifying channel subfamily J member 1 S homeolog	Xenopus laevis	107-112
12615924-4	2003	In this study we investigate the molecular mechanism for PKC regulation of ROMK and report that mutants of ROMK1 with reduced PIP(2) affinity exhibit an increased sensitivity to inhibition by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	219-222	potassium inwardly rectifying channel subfamily J member 1 S homeolog	Xenopus laevis	75-79
12615924-4	2003	In this study we investigate the molecular mechanism for PKC regulation of ROMK and report that mutants of ROMK1 with reduced PIP(2) affinity exhibit an increased sensitivity to inhibition by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	219-222	potassium inwardly rectifying channel subfamily J member 1 S homeolog	Xenopus laevis	107-112
12652654-2	2003	The ability of phorbol myristyl acetate (PMA), a protein kinase C activator that has been reported to increase macrophage spreading and carcinoma cell motility, to rescue these hck(-/-)fgr(-/-) defects was tested.	Tetradecanoylphorbol Acetate	41-44	hemopoietic cell kinase	Mus musculus	177-180
12652654-3	2003	Although PMA-treated wild-type and hck(-/-)fgr(-/-) macrophages exhibited a similar flattened, spread phenotype, PMA did not rescue the hck(-/-)fgr(-/-) macrophage migration defect.	Tetradecanoylphorbol Acetate	9-12	hemopoietic cell kinase	Mus musculus	35-38
12566449-4	2003	A 12-O-tetradecanoylphorbol-13-acetate response element (TRE) located 5" to the estrogen response element was necessary for cAMP-dependent activation of gene expression by ER beta but not ER alpha, indicating that the former subtype requires a functional interaction with TRE-interacting factor(s) to stimulate transcription.	Tetradecanoylphorbol Acetate	2-38	estrogen receptor 2	Gallus gallus	172-179
12694199-2	2003	We have previously shown that DNase II expression is up-regulated at the transcriptional level during the phorbol 12-myristate-13-acetate (PMA)-induced differentiation of HL-60 and THP-1 cells.	Tetradecanoylphorbol Acetate	106-137	Deoxyribonuclease II	Drosophila melanogaster	30-38
12694199-2	2003	We have previously shown that DNase II expression is up-regulated at the transcriptional level during the phorbol 12-myristate-13-acetate (PMA)-induced differentiation of HL-60 and THP-1 cells.	Tetradecanoylphorbol Acetate	139-142	Deoxyribonuclease II	Drosophila melanogaster	30-38
12656657-3	2003	After the analysis of the lymphocyte sub-populations, the intracellular content of interferon-gamma (IFN-gamma) in phorbolmyristate acetate (PMA)-stimulated CD4+ and CD8+ lymphocytes was assayed.	Tetradecanoylphorbol Acetate	141-144	CD8a molecule	Homo sapiens	166-169
12632075-0	2003	Rhein inhibits TPA-induced activator protein-1 activation and cell transformation by blocking the JNK-dependent pathway.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 8	Mus musculus	98-101
12651935-2	2003	To examine this regulation at the signal transduction level, we treated cultured dental follicle cells with either phorbolmyristate acetate (PMA) or dibutyryl cyclic AMP (dbcAMP) to activate either protein kinase C (PKC) or protein kinase A (PKA).	Tetradecanoylphorbol Acetate	115-139	protein kinase C, alpha	Rattus norvegicus	216-219
12788669-7	2003	Administration of TPA, Con-A, and RGD increased the expression of MMPs 1, 2, 9, and 10.	Tetradecanoylphorbol Acetate	18-21	matrix metallopeptidase 9	Homo sapiens	66-70
12788669-9	2003	MAPK-I had no effect on constitutive MMP expression but reduced or abolished the TPA up-regulation of MMP-9 in MDA-MB-231 and MCF-7.	Tetradecanoylphorbol Acetate	81-84	matrix metallopeptidase 9	Homo sapiens	102-107
12634378-6	2003	A striking feature of Rta-mediated lytic gene expression was that Rta induced KSHV gene expression in a more powerful and efficient manner than TPA stimulation, indicating that Rta plays a central, leading role in KSHV lytic gene expression.	Tetradecanoylphorbol Acetate	144-147	ORF50	Human gammaherpesvirus 8	22-25
12645577-2	2003	TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ICAM-1 promoter activity was inhibited by a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2).	Tetradecanoylphorbol Acetate	14-50	intercellular adhesion molecule 1	Homo sapiens	65-71
12645577-2	2003	TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ICAM-1 promoter activity was inhibited by a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2).	Tetradecanoylphorbol Acetate	52-55	intercellular adhesion molecule 1	Homo sapiens	65-71
12645577-5	2003	Furthermore, the dominant-negative c-Src (KM) mutant inhibited induction of ICAM-1 promoter activity by TNF-alpha or TPA.	Tetradecanoylphorbol Acetate	117-120	intercellular adhesion molecule 1	Homo sapiens	76-82
11772950-4	2002	Angiostatin blocked chemotaxis of neutrophils to CXCR2 chemokine receptor agonists (IL-8, MIP-2, and GROalpha), formyl-Met-Leu-Phe (fMLP), and 12-O-tetradecanoylphorbol 13-acetate, and repressed fMLP-induced mitochondrial activity.	Tetradecanoylphorbol Acetate	143-179	chemokine (C-X-C motif) receptor 2	Mus musculus	49-54
11820927-4	2002	The addition of 10 nM TPA to skin epidermal cells from newborn mice resulted in a twofold increase in cholesterol sulfation and concomitantly enhanced the St2b2 content after 40 h. Other candidate cholesterol sulfotransferases, St2a4 and St2a9, were not detected in skin by RT-PCR.	Tetradecanoylphorbol Acetate	22-25	sulfotransferase family 1B, member 1	Mus musculus	155-160
11853879-5	2002	Treatment of B16 cells with TPA or alphaMSH rapidly stimulated ODC activity.	Tetradecanoylphorbol Acetate	28-31	ornithine decarboxylase, structural 1	Mus musculus	63-66
11785980-5	2002	Deletion also significantly decreased the phorbol 12-myristate 13-acetate (PMA)-induced release of GHBP and the accumulation of membrane-anchored remnant proteins.	Tetradecanoylphorbol Acetate	42-73	growth hormone receptor	Homo sapiens	99-103
11785980-5	2002	Deletion also significantly decreased the phorbol 12-myristate 13-acetate (PMA)-induced release of GHBP and the accumulation of membrane-anchored remnant proteins.	Tetradecanoylphorbol Acetate	75-78	growth hormone receptor	Homo sapiens	99-103
12598935-4	2003	Pretreatment with L-Arg (100 micromol/L) decreased significantly Ang II -activated PKC activity and PKC activity induced by phorbol 12-myristate 13-acetate (PMA) ( 10 micromol/L), a PKC activator.	Tetradecanoylphorbol Acetate	124-155	protein kinase C, gamma	Rattus norvegicus	83-86
12598935-4	2003	Pretreatment with L-Arg (100 micromol/L) decreased significantly Ang II -activated PKC activity and PKC activity induced by phorbol 12-myristate 13-acetate (PMA) ( 10 micromol/L), a PKC activator.	Tetradecanoylphorbol Acetate	124-155	protein kinase C, gamma	Rattus norvegicus	100-103
11839145-3	2002	Treatment with phorbol 12-myristate 13-acetate (PMA) induces differentiation of THP-1 cells into adherent macrophage-like cells, which are susceptible to M-tropic, CCR5-dependent isolates (R5 strains).	Tetradecanoylphorbol Acetate	15-46	C-C motif chemokine receptor 5	Homo sapiens	164-168
34204745-9	2021	The results showed that XN in non-cytotoxic concentrations impaired the PMA-driven migratory and invasive capacity of A549 cells by decreasing the level of expression of MMP-9 and concomitantly increasing the expression of the TIMP-1 protein, i.e., a specific blocker of pro-MMP-9 activation.	Tetradecanoylphorbol Acetate	72-75	matrix metallopeptidase 9	Homo sapiens	170-175
11839145-3	2002	Treatment with phorbol 12-myristate 13-acetate (PMA) induces differentiation of THP-1 cells into adherent macrophage-like cells, which are susceptible to M-tropic, CCR5-dependent isolates (R5 strains).	Tetradecanoylphorbol Acetate	48-51	C-C motif chemokine receptor 5	Homo sapiens	164-168
12142035-1	2002	CD4/CD8 lineage commitment of thymocytes is controlled by the T cell receptor-mediated signals and is mimicked in vitro by a long-pulse stimulation of isolated CD4(+)CD8(+) thymocytes with proper combinations of phorbol myristate acetate and the calcium ionophore ionomycin.	Tetradecanoylphorbol Acetate	212-237	CD8a molecule	Homo sapiens	4-7
12598935-4	2003	Pretreatment with L-Arg (100 micromol/L) decreased significantly Ang II -activated PKC activity and PKC activity induced by phorbol 12-myristate 13-acetate (PMA) ( 10 micromol/L), a PKC activator.	Tetradecanoylphorbol Acetate	124-155	protein kinase C, gamma	Rattus norvegicus	100-103
12598935-4	2003	Pretreatment with L-Arg (100 micromol/L) decreased significantly Ang II -activated PKC activity and PKC activity induced by phorbol 12-myristate 13-acetate (PMA) ( 10 micromol/L), a PKC activator.	Tetradecanoylphorbol Acetate	157-160	protein kinase C, gamma	Rattus norvegicus	83-86
12598935-4	2003	Pretreatment with L-Arg (100 micromol/L) decreased significantly Ang II -activated PKC activity and PKC activity induced by phorbol 12-myristate 13-acetate (PMA) ( 10 micromol/L), a PKC activator.	Tetradecanoylphorbol Acetate	157-160	protein kinase C, gamma	Rattus norvegicus	100-103
12598935-4	2003	Pretreatment with L-Arg (100 micromol/L) decreased significantly Ang II -activated PKC activity and PKC activity induced by phorbol 12-myristate 13-acetate (PMA) ( 10 micromol/L), a PKC activator.	Tetradecanoylphorbol Acetate	157-160	protein kinase C, gamma	Rattus norvegicus	100-103
12592382-3	2003	During this period, phosphorylation of one of the downstream transcriptional factors of MAPK cascade, ATF2, was 3.2- and 2.0-fold induced by TPA and Saikosaponin a, respectively, whereas that of another transcriptional factor, c-jun, was induced by TPA only.	Tetradecanoylphorbol Acetate	141-144	activating transcription factor 2	Homo sapiens	102-106
12592382-3	2003	During this period, phosphorylation of one of the downstream transcriptional factors of MAPK cascade, ATF2, was 3.2- and 2.0-fold induced by TPA and Saikosaponin a, respectively, whereas that of another transcriptional factor, c-jun, was induced by TPA only.	Tetradecanoylphorbol Acetate	141-144	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	227-232
11893077-4	2002	Expression of the CD11b antisense gene in stably transfected U937 cells (as-CD11b cells) resulted in an attenuated response to TPA.	Tetradecanoylphorbol Acetate	127-130	integrin subunit alpha M	Homo sapiens	18-23
12708472-5	2003	Among all neuroblastoma cells, expression of NF-M and CGA was stable at a high level throughout TPA-induced differentiation.	Tetradecanoylphorbol Acetate	96-99	neurofilament medium chain	Homo sapiens	45-49
34204745-11	2021	Furthermore, the XN-treatment counteracted the PMA-induced EMT of the A549 cells by the upregulation of E-cadherin and alpha-E-catenin and the downregulation of N-cadherin, vimentin, and Snail-1 expression.	Tetradecanoylphorbol Acetate	47-50	catenin alpha 1	Homo sapiens	119-134
12708472-6	2003	In TM87-16 and TTC642 MRT cells, synapsin I mRNA promptly increased after TPA differentiation, with the peak level at 6 h, and thereafter, synapsin I mRNA rapidly decreased in a time-dependent manner.	Tetradecanoylphorbol Acetate	74-77	synapsin I	Homo sapiens	33-43
34204745-11	2021	Furthermore, the XN-treatment counteracted the PMA-induced EMT of the A549 cells by the upregulation of E-cadherin and alpha-E-catenin and the downregulation of N-cadherin, vimentin, and Snail-1 expression.	Tetradecanoylphorbol Acetate	47-50	cadherin 2	Homo sapiens	161-171
35578812-2	2022	We demonstrated that expression of IL-38, which exhibits high expression in the skin, is downregulated in human cutaneous squamous cell carcinoma and 7,12-dimethylbenzanthracene/12-O-tetradecanoyl phorbol-13-acetate-induced mouse skin tumorigenesis.	Tetradecanoylphorbol Acetate	178-215	interleukin 1 family member 10	Homo sapiens	35-40
12393862-12	2002	Preliminary studies showed that a protein kinase C activator, phorbol 12-myristate 13-acetate, promoted the cellular processing of hADAM19; however, three calmodulin antagonists, trifluoperazine, W7, and calmidazolium, impaired this cleavage, indicating complex signal pathways may be involved in the processing.	Tetradecanoylphorbol Acetate	62-93	ADAM metallopeptidase domain 19	Homo sapiens	131-138
12452835-5	2002	The resting immune cell lines showed weak or no gp-340 mRNA expression; while the two epithelial cell lines expressed gp-340 at much higher level, which was differentially regulated by phorbol myristate acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	185-210	deleted in malignant brain tumors 1	Homo sapiens	118-124
12452835-5	2002	The resting immune cell lines showed weak or no gp-340 mRNA expression; while the two epithelial cell lines expressed gp-340 at much higher level, which was differentially regulated by phorbol myristate acetate (PMA) treatment.	Tetradecanoylphorbol Acetate	212-215	deleted in malignant brain tumors 1	Homo sapiens	118-124
11893077-4	2002	Expression of the CD11b antisense gene in stably transfected U937 cells (as-CD11b cells) resulted in an attenuated response to TPA.	Tetradecanoylphorbol Acetate	127-130	integrin subunit alpha M	Homo sapiens	76-81
11893077-5	2002	As-CD11b cells demonstrated poor adhesion to solid substrate upon TPA treatment in contrast to U937 control cells.	Tetradecanoylphorbol Acetate	66-69	integrin subunit alpha M	Homo sapiens	3-8
11893077-9	2002	According to the failure to undergo a monocytic differentiation program, TPA treatment of as-CD11b cells resulted in a progressively increasing amount of apoptotic cells whereas the differentiated population of U937 control cells remained alive.	Tetradecanoylphorbol Acetate	73-76	integrin subunit alpha M	Homo sapiens	93-98
12452835-6	2002	In the A549 cells, gp-340 was up-regulated along with the PMA-induced proinflammatory expression of both IL-6 and IL-8.	Tetradecanoylphorbol Acetate	58-61	deleted in malignant brain tumors 1	Homo sapiens	19-25
35043283-8	2022	Epigenomic CpG methyl-seq revealed that FX attenuated TPA-induced differentially methylated regions (DMRs) of Uhrf1 and Dnmt1 genes.	Tetradecanoylphorbol Acetate	54-57	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	110-115
12359735-6	2002	In vivo phosphorylation studies using (32)P(i)-labeled mesangial cells revealed that TPA, PDGF, angiotensin II, and ATP trigger an increased phosphorylation of the neutral ceramidase, which is blocked by the broad spectrum PKC inhibitor Ro-31 8220 but not by CGP 41251, which has a preferential action on Ca(2+)-dependent isoforms, thus suggesting the involvement of a Ca(2+)-independent PKC isoform.	Tetradecanoylphorbol Acetate	85-88	protein kinase C, alpha	Rattus norvegicus	223-226
12359735-6	2002	In vivo phosphorylation studies using (32)P(i)-labeled mesangial cells revealed that TPA, PDGF, angiotensin II, and ATP trigger an increased phosphorylation of the neutral ceramidase, which is blocked by the broad spectrum PKC inhibitor Ro-31 8220 but not by CGP 41251, which has a preferential action on Ca(2+)-dependent isoforms, thus suggesting the involvement of a Ca(2+)-independent PKC isoform.	Tetradecanoylphorbol Acetate	85-88	protein kinase C, alpha	Rattus norvegicus	388-391
11752148-5	2002	The same conditioned media also inhibit phorbol myristate acetate-induced activation of the HIV-1 LTR and activate the signal transducer and activator of transcription 1 (STAT1) protein.	Tetradecanoylphorbol Acetate	40-65	signal transducer and activator of transcription 1	Homo sapiens	171-176
12568491-6	2002	Consistent with this notion, phorbol myristate acetate and ionomycin elicit mucin secretion from SPOC1 cells and HBE xenografts, whereas cyclic nucleotides do not.	Tetradecanoylphorbol Acetate	29-54	solute carrier family 13 member 2	Rattus norvegicus	76-81
35043283-8	2022	Epigenomic CpG methyl-seq revealed that FX attenuated TPA-induced differentially methylated regions (DMRs) of Uhrf1 and Dnmt1 genes.	Tetradecanoylphorbol Acetate	54-57	DNA methyltransferase 1	Homo sapiens	120-125
35095881-8	2021	Patients bearing effector memory CD4 and CD8 T cells with the phenotype of high MD exhibited poorer T-cell responses upon either phorbol 12-myristate-13-acetate (PMA)/ionomycin or SARS-CoV-2 peptide stimulation than those with low MD.	Tetradecanoylphorbol Acetate	129-160	CD8a molecule	Homo sapiens	41-44
11591718-6	2001	Although the NES function of RFP in HepG2 cells is masked by another domain in RFP or by another protein, 12-O-tetradecanoylphorbol-13-acetate treatment or overexpression of constitutively active protein kinase Calpha (PKCalpha) abrogated masking, leading to the cytoplasmic localization of RFP.	Tetradecanoylphorbol Acetate	106-142	tripartite motif containing 27	Homo sapiens	29-32
12433834-9	2002	Electrophoretic mobility shift assays and supershift analyses have revealed that activating protein 1 (AP-1) is the transcription factor binding the cAMP-responsive element/12-O-tetradecanoylphorbol 13-acetate-responsive element located in the ACE promoter after PMA stimulation.	Tetradecanoylphorbol Acetate	173-209	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-107
12433834-12	2002	Our results demonstrate that the two transcription factors, Egr-1 and AP-1, are involved in the PMA-induced ACE transcriptional activation in human endothelial cells via the activation of the extracellular signal-regulated kinase 1/2 signaling pathway.	Tetradecanoylphorbol Acetate	96-99	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	70-74
35087488-3	2021	PMA-induced differentiation in these cells recapitulates steps of megakaryopoiesis including gene activation, expression of CD41/61 and CD61 platelet surface markers and accumulation of intracellular reactive oxygen species (ROS).	Tetradecanoylphorbol Acetate	0-3	integrin subunit alpha 2b	Homo sapiens	124-131
12467977-3	2002	In the presence of AGC10 the cytoplasmic levels of IL-2 protein of CD4(+) and CD8(+) blood lymphocytes stimulated with phorbol myristate acetate (PMA) plus ionomycin were markedly reduced.	Tetradecanoylphorbol Acetate	119-144	CD8a molecule	Homo sapiens	78-81
12467977-3	2002	In the presence of AGC10 the cytoplasmic levels of IL-2 protein of CD4(+) and CD8(+) blood lymphocytes stimulated with phorbol myristate acetate (PMA) plus ionomycin were markedly reduced.	Tetradecanoylphorbol Acetate	146-149	CD8a molecule	Homo sapiens	78-81
12572591-9	2002	Substrate zymography confirmed increased release of MMP-9 in response to PMA (control vs. PMA 10(-8) and PMA 10(-7) mol/l; p &lt; 0.01).	Tetradecanoylphorbol Acetate	73-76	matrix metallopeptidase 9	Homo sapiens	52-57
11768000-5	2001	Exposure of cardiomyocytes to 100 nmol/L 4-beta-phorbol 12-myristate 13-acetate (PMA) caused translocation of PKC-delta from the cytosol to the membrane in the 12W group, whereas in the 50W group, the translocation was attenuated.	Tetradecanoylphorbol Acetate	41-79	protein kinase C, gamma	Rattus norvegicus	110-113
11768000-5	2001	Exposure of cardiomyocytes to 100 nmol/L 4-beta-phorbol 12-myristate 13-acetate (PMA) caused translocation of PKC-delta from the cytosol to the membrane in the 12W group, whereas in the 50W group, the translocation was attenuated.	Tetradecanoylphorbol Acetate	81-84	protein kinase C, gamma	Rattus norvegicus	110-113
12270146-4	2002	TPA-treated CMK cells revealed increased expression of integrins alphaIIb and beta3 only when the cell adhesion persisted, regardless of the difference of culture substratum.	Tetradecanoylphorbol Acetate	0-3	cytidine/uridine monophosphate kinase 1	Homo sapiens	12-15
2513128-1	1989	c-Jun, Jun-B, and Jun-D proteins bind to the TPA response element (TRE) either as homodimers or as Jun-Fos heterodimers.	Tetradecanoylphorbol Acetate	45-48	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
12270146-5	2002	Sustained activation of the MEK1-ERK1/2 pathway is generated in the membrane skeleton by continuous cell adhesion and seems to be essential to TPA-induced megakaryocytic differentiation of CMK cells.	Tetradecanoylphorbol Acetate	143-146	cytidine/uridine monophosphate kinase 1	Homo sapiens	189-192
2513128-1	1989	c-Jun, Jun-B, and Jun-D proteins bind to the TPA response element (TRE) either as homodimers or as Jun-Fos heterodimers.	Tetradecanoylphorbol Acetate	45-48	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-106
11714729-4	2001	Consequently, CD44ICD acts as a signal transduction molecule, where it translocates to the nucleus and activates transcription mediated through the 12-O-tetradecanoylphorbol 13-acetate-responsive element, which is found in numerous genes involved in diverse cellular processes.	Tetradecanoylphorbol Acetate	148-184	CD44 molecule (Indian blood group)	Homo sapiens	14-18
2513129-3	1989	However, cotransfection of c-jun and jun-B into primary rat embryo cells with c-Ha-ras results in a significant decrease in transformation compared with c-jun alone, an event reversed by TPA.	Tetradecanoylphorbol Acetate	187-190	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-32
12065085-11	2002	TPA was the most effective in inducing epidermal ODC activity and [(3)H]thymidine incorporation followed by mezerein, COOH and BPO.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	49-52
2513129-3	1989	However, cotransfection of c-jun and jun-B into primary rat embryo cells with c-Ha-ras results in a significant decrease in transformation compared with c-jun alone, an event reversed by TPA.	Tetradecanoylphorbol Acetate	187-190	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	153-158
2556385-0	1989	Activation of the serum response element and 12-O-tetradecanoylphorbol-13-acetate response element by the activated c-raf-1 protein in a manner independent of protein kinase C. Transfection of the cDNA encoding the activated c-raf-1 protein or addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) or dibutyryl cAMP to NIH/3T3 cells activated the c-fos gene enhancer linked to the chloramphenicol acetyltransferase or luciferase reporter gene.	Tetradecanoylphorbol Acetate	45-81	v-raf-leukemia viral oncogene 1	Mus musculus	116-123
12198164-2	2002	Here we show that the mouse tetradecanoyl phorbol acetate induced sequence 7 (TIS7) protein is a novel transcriptional co-repressor that can associate with the SIN3 complex.	Tetradecanoylphorbol Acetate	28-57	transcriptional regulator, SIN3A (yeast)	Mus musculus	160-164
11514578-9	2001	Our results suggest a novel role for Grb4 in the inhibition of promitogenic enhancer elements such as 12-O-tetradecanoylphorbol-13-acetate-responsive element and SRE.	Tetradecanoylphorbol Acetate	102-138	NCK adaptor protein 2	Homo sapiens	37-41
2556385-0	1989	Activation of the serum response element and 12-O-tetradecanoylphorbol-13-acetate response element by the activated c-raf-1 protein in a manner independent of protein kinase C. Transfection of the cDNA encoding the activated c-raf-1 protein or addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) or dibutyryl cAMP to NIH/3T3 cells activated the c-fos gene enhancer linked to the chloramphenicol acetyltransferase or luciferase reporter gene.	Tetradecanoylphorbol Acetate	45-81	v-raf-leukemia viral oncogene 1	Mus musculus	225-232
11719466-10	2001	Taken together, this study shows that a PKC-epsilon-Raf-1-MEK-ERK-AP1 signaling cascade acts on a 12-O-tetradecanoylphorbol-13-acetate response element-like element to mediate hypoxia-induced GRP78 expression in human gastric cancer cells.	Tetradecanoylphorbol Acetate	98-134	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-69
2556385-0	1989	Activation of the serum response element and 12-O-tetradecanoylphorbol-13-acetate response element by the activated c-raf-1 protein in a manner independent of protein kinase C. Transfection of the cDNA encoding the activated c-raf-1 protein or addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) or dibutyryl cAMP to NIH/3T3 cells activated the c-fos gene enhancer linked to the chloramphenicol acetyltransferase or luciferase reporter gene.	Tetradecanoylphorbol Acetate	256-292	v-raf-leukemia viral oncogene 1	Mus musculus	116-123
12211438-9	2002	The direct PKC stimulator 12-O-tetradecanoylphorbol-13-acetate (PMA) did not induce RANKL mRNA in MS1 cells, but it did up-regulate OPG mRNA and also antagonized osteoclast formation induced by PTH(1-34) in both MS1/spleen cocultures and normal bone marrow cultures.	Tetradecanoylphorbol Acetate	26-62	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	132-135
2556385-0	1989	Activation of the serum response element and 12-O-tetradecanoylphorbol-13-acetate response element by the activated c-raf-1 protein in a manner independent of protein kinase C. Transfection of the cDNA encoding the activated c-raf-1 protein or addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) or dibutyryl cAMP to NIH/3T3 cells activated the c-fos gene enhancer linked to the chloramphenicol acetyltransferase or luciferase reporter gene.	Tetradecanoylphorbol Acetate	256-292	v-raf-leukemia viral oncogene 1	Mus musculus	225-232
12211438-9	2002	The direct PKC stimulator 12-O-tetradecanoylphorbol-13-acetate (PMA) did not induce RANKL mRNA in MS1 cells, but it did up-regulate OPG mRNA and also antagonized osteoclast formation induced by PTH(1-34) in both MS1/spleen cocultures and normal bone marrow cultures.	Tetradecanoylphorbol Acetate	64-67	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	132-135
2556385-0	1989	Activation of the serum response element and 12-O-tetradecanoylphorbol-13-acetate response element by the activated c-raf-1 protein in a manner independent of protein kinase C. Transfection of the cDNA encoding the activated c-raf-1 protein or addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) or dibutyryl cAMP to NIH/3T3 cells activated the c-fos gene enhancer linked to the chloramphenicol acetyltransferase or luciferase reporter gene.	Tetradecanoylphorbol Acetate	294-297	v-raf-leukemia viral oncogene 1	Mus musculus	116-123
12072430-8	2002	We further show that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases BCSG1 mRNA expression and up-regulates BCSG1 promoter activity through the intronic AP1 sites.	Tetradecanoylphorbol Acetate	21-57	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	158-161
11641060-0	2001	Transient translocation of hemidesmosomal bullous pemphigoid antigen 1 from cytosol to membrane fractions by 12-O-tetradecanoylphorbol-13-acetate treatment and Ca2+-switch in a human carcinoma cell line.	Tetradecanoylphorbol Acetate	109-145	dystonin	Homo sapiens	42-70
11641060-2	2001	In this study, we examined the effects of TPA and Ca2+-switch on intracellular localization of BPAG1 by immuno-blotting and immuno-fluorescence microscopy with monoclonal antibodies to the antigen after sub-cellular fractionation.	Tetradecanoylphorbol Acetate	42-45	dystonin	Homo sapiens	95-100
11641060-4	2001	In normal Ca2+-cultured cells, TPA (50 nM) caused a complete translocation of BPAG1 from cytosol to membrane fractions within 10 min, that was inhibited by pretreatment with H7 (a selective PKC inhibitor) at 40 microM.	Tetradecanoylphorbol Acetate	31-34	dystonin	Homo sapiens	78-83
12072430-8	2002	We further show that 12-O-tetradecanoylphorbol-13-acetate (TPA) increases BCSG1 mRNA expression and up-regulates BCSG1 promoter activity through the intronic AP1 sites.	Tetradecanoylphorbol Acetate	59-62	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	158-161
12072430-9	2002	The effect of TPA on BCSG1 transcription is also demonstrated under in vivo conditions in intact cells by using chromatin immunoprecipitation assays that show the TPA-induced binding of c-Jun to the chromatin region encompassing the intronic AP1 sites.	Tetradecanoylphorbol Acetate	14-17	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	186-191
12072430-9	2002	The effect of TPA on BCSG1 transcription is also demonstrated under in vivo conditions in intact cells by using chromatin immunoprecipitation assays that show the TPA-induced binding of c-Jun to the chromatin region encompassing the intronic AP1 sites.	Tetradecanoylphorbol Acetate	14-17	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	242-245
12072430-9	2002	The effect of TPA on BCSG1 transcription is also demonstrated under in vivo conditions in intact cells by using chromatin immunoprecipitation assays that show the TPA-induced binding of c-Jun to the chromatin region encompassing the intronic AP1 sites.	Tetradecanoylphorbol Acetate	163-166	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	186-191
2556385-0	1989	Activation of the serum response element and 12-O-tetradecanoylphorbol-13-acetate response element by the activated c-raf-1 protein in a manner independent of protein kinase C. Transfection of the cDNA encoding the activated c-raf-1 protein or addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) or dibutyryl cAMP to NIH/3T3 cells activated the c-fos gene enhancer linked to the chloramphenicol acetyltransferase or luciferase reporter gene.	Tetradecanoylphorbol Acetate	294-297	v-raf-leukemia viral oncogene 1	Mus musculus	225-232
12072430-9	2002	The effect of TPA on BCSG1 transcription is also demonstrated under in vivo conditions in intact cells by using chromatin immunoprecipitation assays that show the TPA-induced binding of c-Jun to the chromatin region encompassing the intronic AP1 sites.	Tetradecanoylphorbol Acetate	163-166	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	242-245
2511003-1	1989	Fos and Jun proteins form a tight complex which binds specifically to the AP1 recognition sequence, a palindromic DNA element also referred to as the TPA responsive element (TRE).	Tetradecanoylphorbol Acetate	150-153	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-3
12076508-4	2002	Short term exposure to phorbol 12-myristate 13-acetate (TPA), a phorbol ester tumour promoter, or hydrogen peroxide (H(2)O(2)) also activates AP-1 and NF-kappa B binding.	Tetradecanoylphorbol Acetate	23-54	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	142-146
12076508-4	2002	Short term exposure to phorbol 12-myristate 13-acetate (TPA), a phorbol ester tumour promoter, or hydrogen peroxide (H(2)O(2)) also activates AP-1 and NF-kappa B binding.	Tetradecanoylphorbol Acetate	56-59	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	142-146
11641060-5	2001	After 30 min and 4 h of TPA-treatment, BPAG1 was exclusively detected in cytoskeleton fractions.	Tetradecanoylphorbol Acetate	24-27	dystonin	Homo sapiens	39-44
2558432-6	1989	In addition, EGF, insulin, and TPA, like hCG, elevated mRNA levels of competence oncogenes (c-fos and c-myc), albeit to different extents.	Tetradecanoylphorbol Acetate	31-34	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	92-97
11641439-9	2001	PMA challenge of HASMC elicited phosphorylation of the stimulatory PKA-specific phosphorylation site, Ser126 in PDE4D5 in a manner ablated by PD98059, indomethacin, and H89.	Tetradecanoylphorbol Acetate	0-3	phosphodiesterase 4D	Homo sapiens	112-117
11641439-10	2001	We propose that, in HASMC, PMA activates PDE4D5 through an ERK-controlled autocrine mechanism.	Tetradecanoylphorbol Acetate	27-30	phosphodiesterase 4D	Homo sapiens	41-46
11594749-7	2001	These results revealed that low-density lipoprotein receptor-related protein (LRP), which is known to be a receptor for tPA and to be blocked by RAP, was up-regulated by IL-1.	Tetradecanoylphorbol Acetate	120-123	low density lipoprotein receptor-related protein 1	Mus musculus	78-81
11477089-3	2001	The enhancement of human leukocyte antigen-DR alpha expression is at least due to the TPA-dependent induction of the IFN-gamma receptor 1 chain and IFN-gamma receptor 2 chain genes.	Tetradecanoylphorbol Acetate	86-89	interferon gamma receptor 2	Homo sapiens	148-168
12093719-1	2002	OBJECTIVES: To study the proportion and characteristics of potential candidates for the intravenous administration of tissue plasminogen activator (IV-tPA) among patients with cerebral infarction in a Japanese emergency department (ED).	Tetradecanoylphorbol Acetate	151-154	chromosome 20 open reading frame 181	Homo sapiens	118-146
12091246-9	2002	Long-time incubation of type II cells with phorbol myristyl acetate (PMA) reduced HDL-holoparticle uptake and megalin expression.	Tetradecanoylphorbol Acetate	69-72	LDL receptor related protein 2	Rattus norvegicus	110-117
2553289-8	1989	These results indicate that a mechanism susceptible to lipoxygenase inhibitors plays a role not only in the TPA-caused but also in the BrMBA-caused epidermal ODC induction, skin inflammation and tumor promotion.	Tetradecanoylphorbol Acetate	108-111	ornithine decarboxylase, structural 1	Mus musculus	158-161
12091247-2	2002	We have recently shown that phorbol 13-myristate 12-acetate (PMA)-stimulated SPRR1B transcription in Clara-like H441 cells is mainly mediated by activator protein-1 (AP-1) and c-Jun N-terminal kinase-1 (JNK1).	Tetradecanoylphorbol Acetate	61-64	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	145-164
12091247-2	2002	We have recently shown that phorbol 13-myristate 12-acetate (PMA)-stimulated SPRR1B transcription in Clara-like H441 cells is mainly mediated by activator protein-1 (AP-1) and c-Jun N-terminal kinase-1 (JNK1).	Tetradecanoylphorbol Acetate	61-64	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	166-170
11549266-7	2001	Moreover, PMA (phorbol myristate acetate), PKC (protein kinase C) activator, protected U937 cells from okadaic acid-induced apoptosis, abrogated okadaic acid-induced caspase 3 activation, and specifically inhibited downregulation of XIAP (X-linked inhibitor of apoptosis) by okadaic acid.	Tetradecanoylphorbol Acetate	10-13	X-linked inhibitor of apoptosis	Homo sapiens	233-237
2790804-7	1989	These results demonstrate that phenobarbital, like TPA and other tumor promoters, can modulate the EGF receptor system but suggest that it does so without directly competing with EGF for binding to its receptor or by activating protein kinase C.	Tetradecanoylphorbol Acetate	51-54	epidermal growth factor receptor	Rattus norvegicus	99-111
11785657-6	2001	A PKC activator, phorbol 12-myristate 13-acetate (PMA), inhibited insulin-dependent Akt phosphorylation.	Tetradecanoylphorbol Acetate	17-48	protein kinase C, gamma	Rattus norvegicus	2-5
11785657-6	2001	A PKC activator, phorbol 12-myristate 13-acetate (PMA), inhibited insulin-dependent Akt phosphorylation.	Tetradecanoylphorbol Acetate	50-53	protein kinase C, gamma	Rattus norvegicus	2-5
11785657-8	2001	We further showed that the PKC inhibitor, G06983, blocked the PMA-induced inhibition of Akt phosphorylation by insulin.	Tetradecanoylphorbol Acetate	62-65	protein kinase C, gamma	Rattus norvegicus	27-30
12097169-4	2002	In this study, we examined the expression of PACE4 and furin during the differentiation of megakaryoblastic cell lines, Dami and HEL cells, induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	151-182	proprotein convertase subtilisin/kexin type 6	Homo sapiens	45-50
12097169-4	2002	In this study, we examined the expression of PACE4 and furin during the differentiation of megakaryoblastic cell lines, Dami and HEL cells, induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	184-187	proprotein convertase subtilisin/kexin type 6	Homo sapiens	45-50
12134900-6	2002	In addition, PMA-induced downregulation of TIMP-1 and TIMP-2 secretion and upregulation of the membrane type I MMP, a major activator of MMP-2 on the cell surface, were reversed by SB203580 in these cells; the PMA-induced increase of invasion in vitro decreased when SB203580 was added to the top compartment of a modified Boyden chamber; and the inhibitor also reduced the MMP secretion and PMA-induced in vitro invasion in various glioma cell lines.	Tetradecanoylphorbol Acetate	13-16	TIMP metallopeptidase inhibitor 2	Homo sapiens	54-60
2555163-2	1989	This factor, although distinct from PEA1 (AP1), is activated by the same oncogenes (v-src, polyoma (Py) middle T, c-Ha-ras, v-mos, v-raf), by tetradecanoyl phorbol-acetate (TPA) and by serum components.	Tetradecanoylphorbol Acetate	142-171	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-45
12082614-5	2002	Glucocorticoids, which exhibit potent anti-inflammatory and anti-tumor promoting activities repressed TPA-mediated S100A8 and S100A9 induction in wild type, but not in c-fos(-/-) mice, thus identifying both genes as the first examples of AP-1 target genes whose repression of TPA-induced transcription by glucocorticoids depends on c-Fos.	Tetradecanoylphorbol Acetate	102-105	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	126-132
2555163-2	1989	This factor, although distinct from PEA1 (AP1), is activated by the same oncogenes (v-src, polyoma (Py) middle T, c-Ha-ras, v-mos, v-raf), by tetradecanoyl phorbol-acetate (TPA) and by serum components.	Tetradecanoylphorbol Acetate	173-176	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	42-45
2559125-0	1989	[Transcriptional activation mechanisms of TPA- and cAMP-inducible genes: TRE and CRE].	Tetradecanoylphorbol Acetate	42-45	tRNA-Glu (anticodon TTC) 3-1	Homo sapiens	73-76
11912190-11	2002	Phorbol 12-myristate 13-acetate caused phosphorylation of Ng in WT mice and promoted the translocation of PKC from the cytosolic to the particulate fractions of both the WT and KO mice, albeit to a lesser extent in the latter.	Tetradecanoylphorbol Acetate	0-31	neurogranin	Mus musculus	58-60
12054499-3	2002	As shown by gelatin zymography, both FGF-2 and TPA stimulated the secretion of MMP-9 in MCF-7 cells while they did not change the level of MMP-2 secretion.	Tetradecanoylphorbol Acetate	47-50	matrix metallopeptidase 9	Homo sapiens	79-84
11550977-8	2001	The [125I]-GM-CSF binding to the cells was slightly increased with phorbol 12-myristate 13-acetate (PMA), insulin-like growth factor-I, platelet derived growth factor, basic fibroblast growth factor, and tumor necrosis factor-alpha, and decreased with pertussis toxin, cholera toxin, and interleukin-1beta.	Tetradecanoylphorbol Acetate	67-98	colony stimulating factor 2	Rattus norvegicus	11-17
11502881-8	2001	Furthermore, the PMA-induced extracellular signal-regulated kinase 1/2 and c-Jun amino-terminal kinase activities that contributed to AP-1 activity and MCP-1 gene induction were obviously attenuated after pretreating ECs with Wog.	Tetradecanoylphorbol Acetate	17-20	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-80
12054499-5	2002	The FGF-2- and TPA-induced MMP-9 secretion was significantly inhibited by transient transfection of MCF-7 cells with dominant negative Ras (Ras-N17) and by treatment with MEK(1/2) inhibitor PD98059.	Tetradecanoylphorbol Acetate	15-18	matrix metallopeptidase 9	Homo sapiens	27-32
2790191-3	1989	Incubation with the differentiating agent phorbol-12-myristate-13-acetate markedly increased the percentage of cells with the CD4- CD8+ phenotype, suggesting that leukemic cells were already committed towards a differentiated element with the CD4- CD8+ phenotype.	Tetradecanoylphorbol Acetate	42-73	CD8a molecule	Homo sapiens	131-134
12054499-6	2002	A pan-protein kinase C (PKC) inhibitor, GF109203X, was found to totally abolish the FGF-2- and TPA-induced MMP-9 secretion and ERK(1/2) phosphorylation.	Tetradecanoylphorbol Acetate	95-98	matrix metallopeptidase 9	Homo sapiens	107-112
12054499-8	2002	These results demonstrated that FGF-2 and TPA induce MMP-9 secretion in MCF-7 cells mainly through PKC-dependent activation of the Ras/ERK(1/2) signaling pathway.	Tetradecanoylphorbol Acetate	42-45	matrix metallopeptidase 9	Homo sapiens	53-58
12032864-5	2002	To determine if TPA-induced ODC activity and associated putrescine levels in PKCdelta transgenic mice contributed to PKCdelta-mediated suppression of skin tumor promotion by TPA, the irreversible inhibitor of ODC, alpha-difluoromethylornithine (DFMO), was used.	Tetradecanoylphorbol Acetate	16-19	protein kinase C, delta	Mus musculus	77-85
12032864-5	2002	To determine if TPA-induced ODC activity and associated putrescine levels in PKCdelta transgenic mice contributed to PKCdelta-mediated suppression of skin tumor promotion by TPA, the irreversible inhibitor of ODC, alpha-difluoromethylornithine (DFMO), was used.	Tetradecanoylphorbol Acetate	16-19	protein kinase C, delta	Mus musculus	117-125
11561718-1	2001	The effects of forskolin (FSK) and phobol 12-myristate-13-acetate (PMA) on c-fos and c-jun mRNA expressions in rat C6 glioma cells were studied.	Tetradecanoylphorbol Acetate	67-70	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	75-80
11561718-6	2001	Cycloheximide (CHX) caused a superinduction of the FSK- or PMA-induced c-fos mRNA level.	Tetradecanoylphorbol Acetate	59-62	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	71-76
12032864-5	2002	To determine if TPA-induced ODC activity and associated putrescine levels in PKCdelta transgenic mice contributed to PKCdelta-mediated suppression of skin tumor promotion by TPA, the irreversible inhibitor of ODC, alpha-difluoromethylornithine (DFMO), was used.	Tetradecanoylphorbol Acetate	16-19	ornithine decarboxylase, structural 1	Mus musculus	209-212
2790191-3	1989	Incubation with the differentiating agent phorbol-12-myristate-13-acetate markedly increased the percentage of cells with the CD4- CD8+ phenotype, suggesting that leukemic cells were already committed towards a differentiated element with the CD4- CD8+ phenotype.	Tetradecanoylphorbol Acetate	42-73	CD8a molecule	Homo sapiens	248-251
12032864-5	2002	To determine if TPA-induced ODC activity and associated putrescine levels in PKCdelta transgenic mice contributed to PKCdelta-mediated suppression of skin tumor promotion by TPA, the irreversible inhibitor of ODC, alpha-difluoromethylornithine (DFMO), was used.	Tetradecanoylphorbol Acetate	174-177	protein kinase C, delta	Mus musculus	117-125
12032864-6	2002	PKCdelta transgenic mice and their wild-type littermates were initiated with 100 nmol DMBA and then promoted twice weekly with 5 nmol TPA.	Tetradecanoylphorbol Acetate	134-137	protein kinase C, delta	Mus musculus	0-8
11517301-5	2001	Stable expression of dnIkkbeta also blocked phorbol 12-myristate 13-acetate (PMA)-induced activation of NF-kappaB and overexpression of cyclin D1, concomitantly with the loss or reduced tumorigenic potential of these cells.	Tetradecanoylphorbol Acetate	44-75	cyclin D1	Mus musculus	136-145
11517301-5	2001	Stable expression of dnIkkbeta also blocked phorbol 12-myristate 13-acetate (PMA)-induced activation of NF-kappaB and overexpression of cyclin D1, concomitantly with the loss or reduced tumorigenic potential of these cells.	Tetradecanoylphorbol Acetate	77-80	cyclin D1	Mus musculus	136-145
2506174-8	1989	The effect of two inhibitors of protein kinases, H-7 and staurosporine, on PMA-induced tPA antigen secretion and tPA mRNA levels were examined.	Tetradecanoylphorbol Acetate	75-78	chromosome 20 open reading frame 181	Homo sapiens	87-90
11500047-2	2001	Here we showed that in cultured human vascular smooth muscle cells (SMC), the PKC stimulator phorbol 12-myristate 13-acetate (PMA) inhibited [(3)H]thymidine incorporation in response to the growth factor PDGF associated with downregulation of PDGFbeta (but not alpha) receptors, which was recovered to normal level after PKC was depleted.	Tetradecanoylphorbol Acetate	93-124	platelet derived growth factor subunit B	Homo sapiens	243-251
11500047-2	2001	Here we showed that in cultured human vascular smooth muscle cells (SMC), the PKC stimulator phorbol 12-myristate 13-acetate (PMA) inhibited [(3)H]thymidine incorporation in response to the growth factor PDGF associated with downregulation of PDGFbeta (but not alpha) receptors, which was recovered to normal level after PKC was depleted.	Tetradecanoylphorbol Acetate	126-129	platelet derived growth factor subunit B	Homo sapiens	243-251
12082627-5	2002	The AP-1 activator phorbol 12-myristate 13-acetate (TPA) enhanced the binding of this DR4 AP-1 binding site to protein(s) in a nuclear extract from TPA-treated cells, increased luciferase activity of a reporter construct containing this site and induced DR4 expression at the transcription level.	Tetradecanoylphorbol Acetate	19-50	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-8
12082627-5	2002	The AP-1 activator phorbol 12-myristate 13-acetate (TPA) enhanced the binding of this DR4 AP-1 binding site to protein(s) in a nuclear extract from TPA-treated cells, increased luciferase activity of a reporter construct containing this site and induced DR4 expression at the transcription level.	Tetradecanoylphorbol Acetate	19-50	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-94
11964282-7	2002	CHOK1 cells stably expressing CD33 with cytoplasmic tails of various length also showed phorbol myristate acetate (PMA)-dependent phosphorylation of CD33.	Tetradecanoylphorbol Acetate	88-113	LOW QUALITY PROTEIN: myeloid cell surface antigen CD33	Cricetulus griseus	30-34
2507902-5	1989	Transforming ras protein activated an intracellular signal pathway, which led to the induction of 12-O-tetradecanoyl phorbol-13-acetate-responsive elements; activation was enhanced by coexpression of the proto-oncogene jun (encoding AP-1) and was further augmented by fos.	Tetradecanoylphorbol Acetate	98-135	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	268-271
11964282-7	2002	CHOK1 cells stably expressing CD33 with cytoplasmic tails of various length also showed phorbol myristate acetate (PMA)-dependent phosphorylation of CD33.	Tetradecanoylphorbol Acetate	88-113	LOW QUALITY PROTEIN: myeloid cell surface antigen CD33	Cricetulus griseus	149-153
11964282-7	2002	CHOK1 cells stably expressing CD33 with cytoplasmic tails of various length also showed phorbol myristate acetate (PMA)-dependent phosphorylation of CD33.	Tetradecanoylphorbol Acetate	115-118	LOW QUALITY PROTEIN: myeloid cell surface antigen CD33	Cricetulus griseus	30-34
11964282-7	2002	CHOK1 cells stably expressing CD33 with cytoplasmic tails of various length also showed phorbol myristate acetate (PMA)-dependent phosphorylation of CD33.	Tetradecanoylphorbol Acetate	115-118	LOW QUALITY PROTEIN: myeloid cell surface antigen CD33	Cricetulus griseus	149-153
2813854-6	1989	Administration of phorbol ester (PMA 10-100 nM, a PK-C activator) alone significantly provoked gastrin release, but markedly inhibited the BBS (1 nM) stimulated gastrin secretion in a dose-dependent manner.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, gamma	Rattus norvegicus	50-54
11507056-3	2001	K5-AZ mice treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) at 0 and 24 h exhibit increases in epidermal and dermal ODC activity that are reduced in magnitude.	Tetradecanoylphorbol Acetate	24-60	ornithine decarboxylase, structural 1	Mus musculus	123-126
11507056-3	2001	K5-AZ mice treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) at 0 and 24 h exhibit increases in epidermal and dermal ODC activity that are reduced in magnitude.	Tetradecanoylphorbol Acetate	62-65	ornithine decarboxylase, structural 1	Mus musculus	123-126
11980664-8	2002	Treatment of cells with 12-O-tetradecanoylphorbol-13-acetate to phosphorylate NKX3.1 had no effect on NKX3.1 coactivation of serum response factor.	Tetradecanoylphorbol Acetate	24-60	NK3 homeobox 1	Homo sapiens	78-84
11507056-4	2001	K6-AZ mice treated similarly do not show any increased ODC activity or protein after a second application due to TPA-induced expression of AZ protein.	Tetradecanoylphorbol Acetate	113-116	ornithine decarboxylase antizyme 1	Mus musculus	3-5
2736522-5	1989	Pretreatment of CMK cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), a stimulus for protein kinase C, further enhanced the PGE1-induced increase in the cellular cyclic AMP level.	Tetradecanoylphorbol Acetate	31-67	cytidine/uridine monophosphate kinase 1	Homo sapiens	16-19
11504768-11	2001	In combination with TPA, carnosic acid potentiated the expression of VDR and RAR-alpha.	Tetradecanoylphorbol Acetate	20-23	vitamin D receptor	Homo sapiens	69-72
11959130-2	2002	Activation of conventional PKCs (cPKCs) and novel PKCs (nPKCs) using 10 nM phorbol 12-myristate 13-acetate (PMA) significantly inhibited DAT-associated transport currents.	Tetradecanoylphorbol Acetate	75-106	solute carrier family 6 member 3	Homo sapiens	137-140
11959130-2	2002	Activation of conventional PKCs (cPKCs) and novel PKCs (nPKCs) using 10 nM phorbol 12-myristate 13-acetate (PMA) significantly inhibited DAT-associated transport currents.	Tetradecanoylphorbol Acetate	108-111	solute carrier family 6 member 3	Homo sapiens	137-140
2736522-5	1989	Pretreatment of CMK cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), a stimulus for protein kinase C, further enhanced the PGE1-induced increase in the cellular cyclic AMP level.	Tetradecanoylphorbol Acetate	69-72	cytidine/uridine monophosphate kinase 1	Homo sapiens	16-19
2736522-6	1989	Inversely, pretreatment of CMK cells with TPA (10 nM), prior to the addition of PGE1, inhibited the PGE1-induced elevation of [Ca2+]i.	Tetradecanoylphorbol Acetate	42-45	cytidine/uridine monophosphate kinase 1	Homo sapiens	27-30
12058964-7	2002	TPA induced MMP-9 activity in MCF-7 cells and increased its activity in MDA-MB-231 cells, however, MMP-2 activity was not detected.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	12-17
11483407-7	2001	12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC activator, stimulated ICAM-1 expression, this effect was inhibited by genistein or tyrphostin 23.	Tetradecanoylphorbol Acetate	0-36	intercellular adhesion molecule 1	Homo sapiens	72-78
2769792-3	1989	In contrast, EGF, FGF, and TPA were equally effective in inducing accumulation of TIS8 and TIS28/c-fos mRNAs.	Tetradecanoylphorbol Acetate	27-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	97-102
11483407-7	2001	12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC activator, stimulated ICAM-1 expression, this effect was inhibited by genistein or tyrphostin 23.	Tetradecanoylphorbol Acetate	38-41	intercellular adhesion molecule 1	Homo sapiens	72-78
11483407-12	2001	TPA also stimulated NF-kappaB DNA-protein binding and ICAM-1 promoter activity, these effects being inhibited by genistein or tyrphostin 23.	Tetradecanoylphorbol Acetate	0-3	intercellular adhesion molecule 1	Homo sapiens	54-60
11483407-13	2001	TNF-alpha- or TPA-induced ICAM-1 promoter activity was inhibited by dominant negative PKCalpha or IKK2, but not IKK1 mutant.	Tetradecanoylphorbol Acetate	14-17	intercellular adhesion molecule 1	Homo sapiens	26-32
11483407-13	2001	TNF-alpha- or TPA-induced ICAM-1 promoter activity was inhibited by dominant negative PKCalpha or IKK2, but not IKK1 mutant.	Tetradecanoylphorbol Acetate	14-17	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	112-116
11994133-4	2002	Phorbol-12-myristate-13-acetate (PMA), but not the inactive analogue 4 alpha-PMA, induced a redistribution of both types of secretory vesicles near the plasma membrane, and this change was abolished by a protein kinase C (PKC) inhibitor, bisindolylmaleimide I (BIS).	Tetradecanoylphorbol Acetate	0-31	protein kinase C, gamma	Rattus norvegicus	204-220
11994133-4	2002	Phorbol-12-myristate-13-acetate (PMA), but not the inactive analogue 4 alpha-PMA, induced a redistribution of both types of secretory vesicles near the plasma membrane, and this change was abolished by a protein kinase C (PKC) inhibitor, bisindolylmaleimide I (BIS).	Tetradecanoylphorbol Acetate	0-31	protein kinase C, gamma	Rattus norvegicus	222-225
11994133-4	2002	Phorbol-12-myristate-13-acetate (PMA), but not the inactive analogue 4 alpha-PMA, induced a redistribution of both types of secretory vesicles near the plasma membrane, and this change was abolished by a protein kinase C (PKC) inhibitor, bisindolylmaleimide I (BIS).	Tetradecanoylphorbol Acetate	33-36	protein kinase C, gamma	Rattus norvegicus	204-220
11994133-4	2002	Phorbol-12-myristate-13-acetate (PMA), but not the inactive analogue 4 alpha-PMA, induced a redistribution of both types of secretory vesicles near the plasma membrane, and this change was abolished by a protein kinase C (PKC) inhibitor, bisindolylmaleimide I (BIS).	Tetradecanoylphorbol Acetate	33-36	protein kinase C, gamma	Rattus norvegicus	222-225
11560779-7	2001	The contributions of these binding sites and the roles of the transcription factors Egr-1, AP-2, and Sp1 in the activation of hMnSOD transcription by TPA were investigated by site-directed mutation analysis, Western blotting, and overexpression of transcription factors.	Tetradecanoylphorbol Acetate	150-153	transcription factor AP-2 alpha	Homo sapiens	91-95
2500364-4	1989	CA II mRNA was also induced to a lesser extent by 12-O-tetradecanoyl phorbol 13-acetate.	Tetradecanoylphorbol Acetate	50-87	carbonic anhydrase 2	Homo sapiens	0-5
11884618-5	2002	In several types of mammalian cells, RACK1 interacted with IGF-IR, protein kinase C, and beta1 integrin in response to IGF-I and phorbol 12-myristate 13-acetate stimulation.	Tetradecanoylphorbol Acetate	129-160	receptor for activated C kinase 1	Homo sapiens	37-42
11884618-5	2002	In several types of mammalian cells, RACK1 interacted with IGF-IR, protein kinase C, and beta1 integrin in response to IGF-I and phorbol 12-myristate 13-acetate stimulation.	Tetradecanoylphorbol Acetate	129-160	insulin like growth factor 1 receptor	Homo sapiens	59-65
11884618-5	2002	In several types of mammalian cells, RACK1 interacted with IGF-IR, protein kinase C, and beta1 integrin in response to IGF-I and phorbol 12-myristate 13-acetate stimulation.	Tetradecanoylphorbol Acetate	129-160	integrin subunit beta 1	Homo sapiens	89-103
2542306-3	1989	ANF secretion was stimulated approximately 4-fold after a 1-h incubation of the cultures with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA); maximal release occurred at about 100 nM TPA.	Tetradecanoylphorbol Acetate	112-148	natriuretic peptide A	Rattus norvegicus	0-3
11909979-4	2002	The knockout of both MSK1 and MSK2 resulted in a 50% reduction in c-fos and junB gene transcription in response to anisomycin or UV-C radiation but only a small reduction in response to tetradecanoyl phorbol acetate or epidermal growth factor in fibroblasts.	Tetradecanoylphorbol Acetate	186-215	ribosomal protein S6 kinase, polypeptide 4	Mus musculus	30-34
11481619-6	2001	Treatment of HepG2 cells with phorbol-12-myristate-13-acetate (PMA) resulted in a rapid decrease of apically localized MRP2 and a loss of more than 90% of pseudocanaliculi within 4 hours.	Tetradecanoylphorbol Acetate	30-61	ATP binding cassette subfamily C member 2	Homo sapiens	119-123
11481619-6	2001	Treatment of HepG2 cells with phorbol-12-myristate-13-acetate (PMA) resulted in a rapid decrease of apically localized MRP2 and a loss of more than 90% of pseudocanaliculi within 4 hours.	Tetradecanoylphorbol Acetate	63-66	ATP binding cassette subfamily C member 2	Homo sapiens	119-123
2542306-3	1989	ANF secretion was stimulated approximately 4-fold after a 1-h incubation of the cultures with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA); maximal release occurred at about 100 nM TPA.	Tetradecanoylphorbol Acetate	150-153	natriuretic peptide A	Rattus norvegicus	0-3
11481619-8	2001	Interestingly, PMA treatment (1-100 nmol/L) led to the appearance of immunoreactive MRP2 at the basolateral membrane within 30 minutes.	Tetradecanoylphorbol Acetate	15-18	ATP binding cassette subfamily C member 2	Homo sapiens	84-88
12013527-5	2002	Thus, PAF increased the TPA- and terbutaline-stimulated phosphatidylcholine secretion, that are PKC and PKA activators respectively, suggesting the involvement of both protein kinases in the process.	Tetradecanoylphorbol Acetate	24-27	PCNA clamp associated factor	Rattus norvegicus	6-9
2542306-3	1989	ANF secretion was stimulated approximately 4-fold after a 1-h incubation of the cultures with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA); maximal release occurred at about 100 nM TPA.	Tetradecanoylphorbol Acetate	197-200	natriuretic peptide A	Rattus norvegicus	0-3
2542306-4	1989	Reversed-phase high performance liquid chromatography analysis of secreted material indicated that the cells efficiently cosecretionally processed ANF under both basal and TPA-stimulated conditions.	Tetradecanoylphorbol Acetate	172-175	natriuretic peptide A	Rattus norvegicus	147-150
11511407-3	2001	RESULTS: Using the nuclear transcription factor CREB as a target, both the activation of the cyclic AMP-PKA pathway by isoproterenol and the activation of the PKC pathway by PMA caused phosphorylation of nuclear CREB.	Tetradecanoylphorbol Acetate	174-177	cAMP responsive element binding protein 1	Homo sapiens	48-52
2542306-5	1989	However, incubating the cultures for more than 1 h with TPA resulted in a blunted secretory response to further TPA challenge and a 40-50% decrease in the quantity of ANF in the cells.	Tetradecanoylphorbol Acetate	56-59	natriuretic peptide A	Rattus norvegicus	167-170
11511407-3	2001	RESULTS: Using the nuclear transcription factor CREB as a target, both the activation of the cyclic AMP-PKA pathway by isoproterenol and the activation of the PKC pathway by PMA caused phosphorylation of nuclear CREB.	Tetradecanoylphorbol Acetate	174-177	cAMP responsive element binding protein 1	Homo sapiens	212-216
11866452-4	2002	The expression of annexin 5 mRNA was also augmented by phorbol 12-myristate 13-acetate but not by forskolin.	Tetradecanoylphorbol Acetate	55-86	annexin A5	Rattus norvegicus	18-27
2548844-1	1989	When expressed in Epstein-Barr virus (EBV) latently infected B cells, the EBV early protein EB1 trans-activates as many EBV early genes as does TPA.	Tetradecanoylphorbol Acetate	144-147	microtubule associated protein RP/EB family member 1	Homo sapiens	92-95
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, alpha	Rattus norvegicus	49-58
11832354-5	2002	Phorbol 12-myristate 13-acetate (PMA) stimulated PKC-alpha translocation from the cytosol to the membrane and inhibited approximately 50% of the PTH-(1-34), forskolin, and 8-bromoadenosine 3",5"-cyclic monophosphate-stimulated IGFBP-5 mRNA levels, suggesting that PKC-alpha negatively regulates protein kinase A (PKA)-mediated induction of IGFBP-5 mRNA.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, alpha	Rattus norvegicus	264-273
11493622-6	2001	LPS, zymosan, and PMA caused marked and dose-dependent increases in TNF-alpha and IL-10 production.	Tetradecanoylphorbol Acetate	18-21	interleukin 10	Homo sapiens	82-87
2548844-3	1989	One of them (ZRE-M) overlaps with a consensus TPA responsive element (TRE) defined as an AP-1/c-jun/c-fos binding site and is located in an EBV promoter controlling the expression of the post-transcriptional activator EB2.	Tetradecanoylphorbol Acetate	46-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	94-99
12041912-10	2002	The addition of phorbol 12-myristate 13-acetate increased mRNA expression for both c-fos and 24-hydroxylase in 1,25(OH)2D3-treated UMR-106 cells.	Tetradecanoylphorbol Acetate	16-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-88
2548844-3	1989	One of them (ZRE-M) overlaps with a consensus TPA responsive element (TRE) defined as an AP-1/c-jun/c-fos binding site and is located in an EBV promoter controlling the expression of the post-transcriptional activator EB2.	Tetradecanoylphorbol Acetate	46-49	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	100-105
11421927-0	2001	Expression of adhesion molecules on cord-blood-derived, cultured human mast cells and effect of dexamethasone on intercellular adhesion molecule-1 expression on the mast cells treated by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	187-212	intercellular adhesion molecule 1	Homo sapiens	113-146
11751911-6	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC activator, stimulated ICAM-1 expression; this effect was inhibited by tyrosine kinase or Src inhibitor.	Tetradecanoylphorbol Acetate	0-36	intercellular adhesion molecule 1	Homo sapiens	72-78
11751911-6	2002	12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC activator, stimulated ICAM-1 expression; this effect was inhibited by tyrosine kinase or Src inhibitor.	Tetradecanoylphorbol Acetate	38-41	intercellular adhesion molecule 1	Homo sapiens	72-78
11914583-1	2002	The functional role of mitogen-activated protein kinase (MAPK) signaling and c-Jun induction in phorbol 12-myristate 13-acetate (PMA)-induced human 12(S)-lipoxygenase gene expression was studied in human epidermoid carcinoma A431 cells.	Tetradecanoylphorbol Acetate	96-127	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-82
11421927-8	2001	In contrast, the expression of VLA-4 and Mac-1 was decreased after the incubation with PMA for 24 h. The PMA-induced upregulation of ICAM-1 was inhibited by dexamethasone in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	87-90	intercellular adhesion molecule 1	Homo sapiens	133-139
11421927-8	2001	In contrast, the expression of VLA-4 and Mac-1 was decreased after the incubation with PMA for 24 h. The PMA-induced upregulation of ICAM-1 was inhibited by dexamethasone in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	105-108	intercellular adhesion molecule 1	Homo sapiens	133-139
11914583-1	2002	The functional role of mitogen-activated protein kinase (MAPK) signaling and c-Jun induction in phorbol 12-myristate 13-acetate (PMA)-induced human 12(S)-lipoxygenase gene expression was studied in human epidermoid carcinoma A431 cells.	Tetradecanoylphorbol Acetate	129-132	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-82
2925639-3	1989	Respiratory burst activity was recovered by subsequent addition of a supraoptimal dose of phorbol 12-myristate 13-acetate, indicating that in the presence of the inhibitor only the activation of the NADPH:O2 oxidoreductase via protein kinase C is inhibited, but not the oxidoreductase itself.	Tetradecanoylphorbol Acetate	90-121	thioredoxin reductase 1	Homo sapiens	208-222
11914583-7	2002	Enhancement of binding between the c-Jun-Sp1 complex and the Sp1 oligonucleotide was observed in cells treated with PMA, suggesting the possible interaction of c-Jun-Sp1 with GC-rich binding sites in the gene promoter.	Tetradecanoylphorbol Acetate	116-119	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-40
11914583-7	2002	Enhancement of binding between the c-Jun-Sp1 complex and the Sp1 oligonucleotide was observed in cells treated with PMA, suggesting the possible interaction of c-Jun-Sp1 with GC-rich binding sites in the gene promoter.	Tetradecanoylphorbol Acetate	116-119	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	160-165
2925639-3	1989	Respiratory burst activity was recovered by subsequent addition of a supraoptimal dose of phorbol 12-myristate 13-acetate, indicating that in the presence of the inhibitor only the activation of the NADPH:O2 oxidoreductase via protein kinase C is inhibited, but not the oxidoreductase itself.	Tetradecanoylphorbol Acetate	90-121	thioredoxin reductase 1	Homo sapiens	270-284
11861805-8	2002	In addition, phorbol-12-myristate-13-acetate (PMA, 100 nM), a PKC activator, markedly inhibited glycine-activated current.	Tetradecanoylphorbol Acetate	13-44	protein kinase C, gamma	Rattus norvegicus	62-65
11861805-8	2002	In addition, phorbol-12-myristate-13-acetate (PMA, 100 nM), a PKC activator, markedly inhibited glycine-activated current.	Tetradecanoylphorbol Acetate	46-49	protein kinase C, gamma	Rattus norvegicus	62-65
19003325-3	2001	We investigated the intracellular signaling pathways, which were Ca/CN cascade and Ras/MAPK cascade, of these tolerant CD4 T cells using phorbol-12-myristate-13-acetate (PMA) and ionomycin, which are known to directly stimulate these pathways.	Tetradecanoylphorbol Acetate	137-168	CD4 antigen	Mus musculus	119-122
19003325-3	2001	We investigated the intracellular signaling pathways, which were Ca/CN cascade and Ras/MAPK cascade, of these tolerant CD4 T cells using phorbol-12-myristate-13-acetate (PMA) and ionomycin, which are known to directly stimulate these pathways.	Tetradecanoylphorbol Acetate	170-173	CD4 antigen	Mus musculus	119-122
2545356-3	1989	A protein of Mr 46,000 was observed in the culture medium of Huh-7 Cl-4 cells treated by TPA or plated at low density, but only slightly in the culture medium of Huh-7 Cl-4 cells plated at high density.	Tetradecanoylphorbol Acetate	89-92	MIR7-3 host gene	Homo sapiens	61-66
11435485-0	2001	Retardation of early-onset PMA-induced apoptosis in mouse neutrophils deficient in myeloperoxidase.	Tetradecanoylphorbol Acetate	27-30	myeloperoxidase	Mus musculus	83-98
11870880-5	2002	Treatment of adult HK1.src(529) transgenic mice with the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate resulted in an increase in epidermal hyperplasia and labeling index significantly greater than that seen in nontransgenic littermates.	Tetradecanoylphorbol Acetate	86-122	hexokinase 1	Mus musculus	19-22
11922944-6	2002	Expression of mSSP increased significantly within the first hours of B cell treatment with either CD40L, anti-IgM, or phorbol myristate acetate (PMA) with or without ionomycin.	Tetradecanoylphorbol Acetate	145-148	NOP58 ribonucleoprotein	Mus musculus	14-18
2766409-4	1989	Results obtained in this way showed that the double bond at C-2 and C-3 of the flavonoid structure is a prerequisite for anti-tumor-promoting activity, and indicated that activity in this screening assay for inhibitors of TPA-induced ear edema reflects the anti-tumor-promoting effect in two-stage carcinogenesis.	Tetradecanoylphorbol Acetate	222-225	complement component 2 (within H-2S)	Mus musculus	60-63
11741892-1	2002	Here we demonstrate that phosphorylation of the sphingosine 1-phosphate (SSP) receptor "endothelial differentiation gene 1" (EDG1 or S1P(1)) receptor is increased in response to either SSP or phorbol 12-myristate 13-acetate (PMA) exposure but not lysophosphatidic acid.	Tetradecanoylphorbol Acetate	192-223	sphingosine-1-phosphate receptor 1	Homo sapiens	125-129
11741892-1	2002	Here we demonstrate that phosphorylation of the sphingosine 1-phosphate (SSP) receptor "endothelial differentiation gene 1" (EDG1 or S1P(1)) receptor is increased in response to either SSP or phorbol 12-myristate 13-acetate (PMA) exposure but not lysophosphatidic acid.	Tetradecanoylphorbol Acetate	225-228	sphingosine-1-phosphate receptor 1	Homo sapiens	125-129
11478406-5	2001	RESULTS: PMA promoted a marked transient translocation of ventricular PKCalpha from the cytosol to the membranes within 10 minutes in lean rats, whereas it had a much weaker effect in obese rats.	Tetradecanoylphorbol Acetate	9-12	protein kinase C, alpha	Rattus norvegicus	70-78
2665635-0	1989	Human immunodeficiency virus long terminal repeat responds to transformation by the mutant T24 H-ras1 oncogene and it contains multiple AP-1 binding TPA-inducible consensus sequence elements.	Tetradecanoylphorbol Acetate	149-152	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-140
11352830-5	2001	In vitro experiments using isolated leukocytes treated with phorbol 12-myristate 13-acetate showed that monocytes and neutrophils but not lymphocytes were hyperreactive to cell activation, as measured by CD11b overexpression and increased L-selectin shedding in PPVL rats.	Tetradecanoylphorbol Acetate	60-91	selectin L	Rattus norvegicus	239-249
11751871-3	2002	Further analysis demonstrated that serum or 12-O-tetradecanoylphorbol-13-acetate activation of several immediate early genes including fos, fosB, junB, and egr1 was inhibited by Wnt signaling.	Tetradecanoylphorbol Acetate	44-80	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	135-138
2665635-5	1989	We have noted four motifs in the HIV-1 LTR region which resemble TPA-inducible and AP-1 binding consensus sequences.	Tetradecanoylphorbol Acetate	65-68	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-87
2665635-6	1989	Since H-ras1 fos and jun/AP-1 respond to TPA and T24 H-ras1 is known to induce both fos and jun/AP-1 nuclear transcriptional factors, it is possible that the latter genes play a role in HIV-1 transcription.	Tetradecanoylphorbol Acetate	41-44	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-29
11368535-8	2001	TPA and Vitrogen resulted in up-regulation of MMP-9 in each of the cell lines, while Con-A could up-regulate MMP-9 expression only in SUIT-2.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	46-51
11368535-11	2001	CONCLUSION: These data suggest that, while MMP-2 and MMP-9 are not constitutively expressed in pancreatic carcinoma cell lines, they may be up-regulated by TPA, Con-A, and Vitrogen.	Tetradecanoylphorbol Acetate	156-159	matrix metallopeptidase 9	Homo sapiens	53-58
11458449-6	2001	In addition, baicalein inhibited the expressions of ELAM-1 and ICAM-1 stimulated by protein kinase C (PKC) activator phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	117-142	intercellular adhesion molecule 1	Homo sapiens	63-69
11924871-2	2002	In an attempt to clarify how tPA favors ischemia-induced neuronal damage, we performed in vitro electrophysiological experiments in striatal slices by using mice selectively lacking this serine protease.We found that tPA ablation did not affect the membrane depolarization of striatal neurons exposed to combined oxygen and glucose deprivation but fully prevented the induction of NMDA-dependent post-ischemic long-term synaptic potentiation.	Tetradecanoylphorbol Acetate	29-32	complement component 1, s subcomponent 1	Mus musculus	187-202
11924871-2	2002	In an attempt to clarify how tPA favors ischemia-induced neuronal damage, we performed in vitro electrophysiological experiments in striatal slices by using mice selectively lacking this serine protease.We found that tPA ablation did not affect the membrane depolarization of striatal neurons exposed to combined oxygen and glucose deprivation but fully prevented the induction of NMDA-dependent post-ischemic long-term synaptic potentiation.	Tetradecanoylphorbol Acetate	217-220	complement component 1, s subcomponent 1	Mus musculus	187-202
2665635-6	1989	Since H-ras1 fos and jun/AP-1 respond to TPA and T24 H-ras1 is known to induce both fos and jun/AP-1 nuclear transcriptional factors, it is possible that the latter genes play a role in HIV-1 transcription.	Tetradecanoylphorbol Acetate	41-44	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	96-100
2564319-2	1989	There is evidence that TPA acts via a specific receptor mechanism involving activation of protein kinase C (pkC).	Tetradecanoylphorbol Acetate	23-26	protein kinase C, gamma	Rattus norvegicus	90-106
11795874-1	2002	Phorbol 12-myristate-13-acetate (PMA), a potent tumor promoter and activator of most protein kinase C (PKC) isotypes, was found to significantly inhibit the growth of low population density (1-5% confluency) NIH 3T3 cells.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, delta	Mus musculus	103-106
11795874-1	2002	Phorbol 12-myristate-13-acetate (PMA), a potent tumor promoter and activator of most protein kinase C (PKC) isotypes, was found to significantly inhibit the growth of low population density (1-5% confluency) NIH 3T3 cells.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, delta	Mus musculus	103-106
11795874-3	2002	PMA-induced growth arrest is accompanied by an elevation in the level of p21(Cip1) protein, along with cell cycle arrest at the G1/S transition.	Tetradecanoylphorbol Acetate	0-3	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	73-76
11795874-3	2002	PMA-induced growth arrest is accompanied by an elevation in the level of p21(Cip1) protein, along with cell cycle arrest at the G1/S transition.	Tetradecanoylphorbol Acetate	0-3	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	77-81
11795874-4	2002	Activation of PKC is required for this growth inhibitory response since the pan PKC inhibitor GF109203 blocked this effect of PMA.	Tetradecanoylphorbol Acetate	126-129	protein kinase C, delta	Mus musculus	14-17
11458449-6	2001	In addition, baicalein inhibited the expressions of ELAM-1 and ICAM-1 stimulated by protein kinase C (PKC) activator phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	144-147	intercellular adhesion molecule 1	Homo sapiens	63-69
2564319-2	1989	There is evidence that TPA acts via a specific receptor mechanism involving activation of protein kinase C (pkC).	Tetradecanoylphorbol Acetate	23-26	protein kinase C, gamma	Rattus norvegicus	108-111
11795874-4	2002	Activation of PKC is required for this growth inhibitory response since the pan PKC inhibitor GF109203 blocked this effect of PMA.	Tetradecanoylphorbol Acetate	126-129	protein kinase C, delta	Mus musculus	80-83
11795879-4	2002	Finally, NADH/NADPH inhibitors prevent the p66(Shc) Ser-phosphorylation induced by serum and by phorbol 12-myristate-13-acetate, which suggests that the direct target(s) of reactive oxygen species is(are) located upstream from the machinery connecting growth factor receptors to Ras.	Tetradecanoylphorbol Acetate	96-127	SHC adaptor protein 1	Homo sapiens	47-50
2784444-0	1989	Comparison of phorbol-12-myristate-13-acetate and dioctanoyl-sn-glycerol in the activation of EL4/6.1 thymoma cells.	Tetradecanoylphorbol Acetate	14-45	epilepsy 4	Mus musculus	94-99
11779137-4	2002	Treatment with the phorbol ester TPA caused translocation of PKC alpha, beta2, and epsilon to the plasma membrane.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, alpha	Rattus norvegicus	61-70
11279008-6	2001	The binding of the Nrf2/small Maf complex to ARE was induced by hemin, whereas the binding of Jun/Fos proteins to ARE was induced by phorbol 12-myristate 13-acetate, but not hemin.	Tetradecanoylphorbol Acetate	133-164	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-101
11287316-3	2001	Phosphorylation of p92 was inducible when Mac-1 was activated by phorbol 12-myristate 13-acetate, the beta(2)-specific activating antibody CBR LFA-1/2, or interleukin-8 (77 amino acids).	Tetradecanoylphorbol Acetate	65-96	integrin subunit alpha M	Homo sapiens	42-47
2784444-2	1989	These cells have been shown to express interleukin-2 receptors (IL-2R) upon stimulation with optimal amounts of PMA (10 ng/ml); also, suboptimal amounts of PMA (1 ng/ml) synergized with the Ca2+ ionophore ionomycin and recombinant interleukin-1 (rIL-1) (Lowenthal et al., 1986).	Tetradecanoylphorbol Acetate	112-115	interleukin 2 receptor, alpha chain	Mus musculus	39-62
2784444-2	1989	These cells have been shown to express interleukin-2 receptors (IL-2R) upon stimulation with optimal amounts of PMA (10 ng/ml); also, suboptimal amounts of PMA (1 ng/ml) synergized with the Ca2+ ionophore ionomycin and recombinant interleukin-1 (rIL-1) (Lowenthal et al., 1986).	Tetradecanoylphorbol Acetate	112-115	interleukin 2 receptor, alpha chain	Mus musculus	64-69
2499943-1	1989	In rabbit platelets, collagen (50 micrograms/ml)- or thrombin (0.5 U/ml)-induced diacylglycerol formation was dose-dependently prevented by phorbol 12-myristate 13-acetate (PMA, 2-50 nM).	Tetradecanoylphorbol Acetate	140-171	prothrombin	Oryctolagus cuniculus	53-61
11301042-3	2001	The current study further investigates the signaling pathways activated by BisA by comparing its effects with those of the PKC agonist phorbol 12-myristate 13-acetate (PMA) in the IEC-18 intestinal crypt cell line.	Tetradecanoylphorbol Acetate	135-166	protein kinase C, alpha	Rattus norvegicus	123-126
11301042-3	2001	The current study further investigates the signaling pathways activated by BisA by comparing its effects with those of the PKC agonist phorbol 12-myristate 13-acetate (PMA) in the IEC-18 intestinal crypt cell line.	Tetradecanoylphorbol Acetate	168-171	protein kinase C, alpha	Rattus norvegicus	123-126
11301042-10	2001	On the other hand, BisA and PMA both promoted PKC-dependent activation of Erk 1 and 2 in this system.	Tetradecanoylphorbol Acetate	28-31	protein kinase C, alpha	Rattus norvegicus	46-49
11817594-10	2002	In addition, CRISP-3 was detected by RT-PCR between 30 minutes and 6 hours in phorbol myristate acetate-activated normal PBLs, while staurosporine inhibited this expression.	Tetradecanoylphorbol Acetate	78-103	cysteine rich secretory protein 3	Homo sapiens	13-20
11380624-2	2001	In this study, we investigated the roles of Syk and other PTKs for the phorbol esters, 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced PLD activation in K562 and DT40 cells.	Tetradecanoylphorbol Acetate	87-123	spleen associated tyrosine kinase	Homo sapiens	44-47
2499943-1	1989	In rabbit platelets, collagen (50 micrograms/ml)- or thrombin (0.5 U/ml)-induced diacylglycerol formation was dose-dependently prevented by phorbol 12-myristate 13-acetate (PMA, 2-50 nM).	Tetradecanoylphorbol Acetate	173-176	prothrombin	Oryctolagus cuniculus	53-61
11380624-2	2001	In this study, we investigated the roles of Syk and other PTKs for the phorbol esters, 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced PLD activation in K562 and DT40 cells.	Tetradecanoylphorbol Acetate	125-128	spleen associated tyrosine kinase	Homo sapiens	44-47
11380624-3	2001	RESULTS: TPA-induced PLD activation was remarkably reduced in both Syk dominant negative mutant K562 cells and Syk deficient DT40 B cells.	Tetradecanoylphorbol Acetate	9-12	spleen associated tyrosine kinase	Homo sapiens	67-70
11380624-3	2001	RESULTS: TPA-induced PLD activation was remarkably reduced in both Syk dominant negative mutant K562 cells and Syk deficient DT40 B cells.	Tetradecanoylphorbol Acetate	9-12	spleen associated tyrosine kinase	Homo sapiens	111-114
12404881-5	2002	At concentrations of 16 and 35 mumol/l, NAC significantly reduced in a concentration-dependent manner the activation of polymorphonuclear neutrophils (PMNs) oxidative bursts induced by all of the stimulants (C. albicans, formyl-methionyl-leucyl-phenylalanine (fMLP), phorbol myristate acetate (PMA)).	Tetradecanoylphorbol Acetate	267-292	X-linked Kx blood group	Homo sapiens	40-43
12404881-5	2002	At concentrations of 16 and 35 mumol/l, NAC significantly reduced in a concentration-dependent manner the activation of polymorphonuclear neutrophils (PMNs) oxidative bursts induced by all of the stimulants (C. albicans, formyl-methionyl-leucyl-phenylalanine (fMLP), phorbol myristate acetate (PMA)).	Tetradecanoylphorbol Acetate	294-297	X-linked Kx blood group	Homo sapiens	40-43
2492471-2	1989	TPA induces also an increase of ornithine decarboxylase (ODC) activity and elevates the intracellular concentrations of putrescine and polyamines within 4-8 h. A similar increase of intracellular putrescine and polyamine concentrations can be achieved by administration of 2 mM putrescine to the culture medium.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	32-55
11756554-3	2002	Tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor induce activator protein 1 (AP-1) activity and neoplastic transformation in JB6 transformation-sensitive (P(+)) cells, but not in transformation-resistant (P(-)) variants.	Tetradecanoylphorbol Acetate	24-60	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-127
2492471-2	1989	TPA induces also an increase of ornithine decarboxylase (ODC) activity and elevates the intracellular concentrations of putrescine and polyamines within 4-8 h. A similar increase of intracellular putrescine and polyamine concentrations can be achieved by administration of 2 mM putrescine to the culture medium.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	57-60
11756554-3	2002	Tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor induce activator protein 1 (AP-1) activity and neoplastic transformation in JB6 transformation-sensitive (P(+)) cells, but not in transformation-resistant (P(-)) variants.	Tetradecanoylphorbol Acetate	62-65	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-127
2492471-4	1989	Putrescine has rather a counter-regulatory effect as concluded from the observation that the TPA-induced TCGF production and IL-2-specific mRNA expression are augmented (superinduced) by the ODC inhibitor D,L-alpha-difluoromethylornithine (DFMO) and again suppressed after the administration of putrescine or polyamines to DFMO-treated cultures.	Tetradecanoylphorbol Acetate	93-96	ornithine decarboxylase, structural 1	Mus musculus	191-194
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	95-120	S100 calcium binding protein A9	Homo sapiens	212-217
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	95-120	S100 calcium binding protein A9	Homo sapiens	265-270
2699432-0	1989	Receptor downregulation and DNA synthesis are modulated by EGF and TPA in cells expressing an EGFR/neu chimera.	Tetradecanoylphorbol Acetate	67-70	epidermal growth factor receptor	Rattus norvegicus	94-98
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	122-125	S100 calcium binding protein A9	Homo sapiens	212-217
11292747-8	2001	As a positive control for inducible expression, immortalized keratinocytes were incubated with phorbol myristate acetate (PMA) (50 ng/ml) for 24 h. Incubation with PMA stimulated increased expression of MRP8 and MRP14 mRNA within 2 h, peaking within 5 h. MRP8- and MRP14-specific mRNA expression by immortalized keratinocytes appeared to be unaffected by LPS or IL-1 beta.	Tetradecanoylphorbol Acetate	122-125	S100 calcium binding protein A9	Homo sapiens	265-270
11312156-4	2001	PMA is known to specifically activate protein kinase C and, indeed, the stimulatory effects of PMA in both cell lines were completely inhibited by the protein kinase inhibitor, staurosporine (100 nM), suggesting that activation of protein kinase C (PKC) may mediate PMA-induced GHBP shedding.	Tetradecanoylphorbol Acetate	0-3	growth hormone receptor	Homo sapiens	278-282
12416263-5	2002	Western and Northern blots indicated that TF-3 significantly reduced the protein and mRNA levels of ODC in TPA-treated mouse skin and NIH 3T3 cells, whereas EGCG showed less activity.	Tetradecanoylphorbol Acetate	107-110	ornithine decarboxylase, structural 1	Mus musculus	100-103
11700037-3	2001	In isolated CD4+CD8+CCR7-thymocytes, a moderate 20-h pulse stimulation with a combination of the calcium ionophore ionomycin and the protein kinase C activator phorbol myristate acetate induced CCR7 expression and CD8 downregulation.	Tetradecanoylphorbol Acetate	160-185	CD8a molecule	Homo sapiens	16-19
11700037-3	2001	In isolated CD4+CD8+CCR7-thymocytes, a moderate 20-h pulse stimulation with a combination of the calcium ionophore ionomycin and the protein kinase C activator phorbol myristate acetate induced CCR7 expression and CD8 downregulation.	Tetradecanoylphorbol Acetate	160-185	CD8a molecule	Homo sapiens	214-217
11312156-4	2001	PMA is known to specifically activate protein kinase C and, indeed, the stimulatory effects of PMA in both cell lines were completely inhibited by the protein kinase inhibitor, staurosporine (100 nM), suggesting that activation of protein kinase C (PKC) may mediate PMA-induced GHBP shedding.	Tetradecanoylphorbol Acetate	95-98	growth hormone receptor	Homo sapiens	278-282
2699432-8	1989	These results show that the chimeric EGFR/neu receptor undergoes typical downregulation upon ligand binding and TPA pretreatment and is capable of transducing an EGF-induced mitogenic signal.	Tetradecanoylphorbol Acetate	112-115	epidermal growth factor receptor	Rattus norvegicus	37-41
2512251-2	1989	Treatment of CD4+ or CD8+ CTL clones with phorbol myristate acetate (PMA), phytohemagglutinin, or mitogenic combinations of CD2-specific antibodies also resulted in CD4 or CD8 phosphorylation.	Tetradecanoylphorbol Acetate	42-67	CD8a molecule	Homo sapiens	21-24
11331935-6	2001	Phosphorylation of Cx43 was increased upon activation of protein kinase C (PKC) by 1 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	92-123	protein kinase C, gamma	Rattus norvegicus	57-73
11331935-6	2001	Phosphorylation of Cx43 was increased upon activation of protein kinase C (PKC) by 1 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	92-123	protein kinase C, gamma	Rattus norvegicus	75-78
11331935-6	2001	Phosphorylation of Cx43 was increased upon activation of protein kinase C (PKC) by 1 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	125-128	protein kinase C, gamma	Rattus norvegicus	57-73
11331935-6	2001	Phosphorylation of Cx43 was increased upon activation of protein kinase C (PKC) by 1 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	125-128	protein kinase C, gamma	Rattus norvegicus	75-78
11733942-7	2001	Application of a PKC activator (PMA; 1mM: phorbol 12-myristate 13-acetate), mimicked the effect of ET-1.	Tetradecanoylphorbol Acetate	42-73	endothelin-1	Cavia porcellus	99-103
11703361-6	2001	As expected, CD8+ T lymphocytes from peripheral blood of healthy volunteers produced significantly more IFN-gamma in the presence of PMA and calcium-ionophore than after stimulation with anti-CD3 antibodies.	Tetradecanoylphorbol Acetate	133-136	CD8a molecule	Homo sapiens	13-16
11703361-7	2001	However, in subjects with allergic asthma, IFN-gamma secretion of CD8+ T cells was significantly higher when incubated with anti-CD3 antibodies than after activation with PMA and calcium-ionophore.	Tetradecanoylphorbol Acetate	171-174	CD8a molecule	Homo sapiens	66-69
2512251-2	1989	Treatment of CD4+ or CD8+ CTL clones with phorbol myristate acetate (PMA), phytohemagglutinin, or mitogenic combinations of CD2-specific antibodies also resulted in CD4 or CD8 phosphorylation.	Tetradecanoylphorbol Acetate	42-67	CD8a molecule	Homo sapiens	172-175
11703361-8	2001	While IFN-gamma secretion of CD8+ T lymphocytes of patients with allergic asthma was lower than that of healthy controls in the presence of PMA/calcium-ionophore, it was significantly elevated when compared with normal controls after stimulation with anti-CD3 antibodies.	Tetradecanoylphorbol Acetate	140-143	CD8a molecule	Homo sapiens	29-32
2512251-2	1989	Treatment of CD4+ or CD8+ CTL clones with phorbol myristate acetate (PMA), phytohemagglutinin, or mitogenic combinations of CD2-specific antibodies also resulted in CD4 or CD8 phosphorylation.	Tetradecanoylphorbol Acetate	69-72	CD8a molecule	Homo sapiens	21-24
2512251-2	1989	Treatment of CD4+ or CD8+ CTL clones with phorbol myristate acetate (PMA), phytohemagglutinin, or mitogenic combinations of CD2-specific antibodies also resulted in CD4 or CD8 phosphorylation.	Tetradecanoylphorbol Acetate	69-72	CD8a molecule	Homo sapiens	172-175
11600479-11	2001	The cause of Behcet"s syndrome is unknown but peripheral blood CD45 gammadelta T cells in Behcet"s produce &gt;50-fold more TNF-alpha than controls when stimulated with phorbol myristate acetate and anti-CD3.	Tetradecanoylphorbol Acetate	169-194	protein tyrosine phosphatase receptor type C	Homo sapiens	63-67
2512251-5	1989	Exposure of these transfectants to PMA induced rapid phosphorylation of the CD4 and CD8 molecules.	Tetradecanoylphorbol Acetate	35-38	CD8a molecule	Homo sapiens	84-87
11356008-3	2001	Here, we report that IL-6 and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically transactivate the IRE in HepG2 cells, which is coupled to a strong upregulation of c-Jun and c-Fos expression by TPA via the mitogen-activated protein kinase (MAPK) pathway.	Tetradecanoylphorbol Acetate	30-66	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-177
2491757-1	1989	The effects of age on the activity and translocation of protein kinase C (PKC) and on the facilitation of 5-hydroxytryptamine (5-HT, serotonin) release induced by PKC activation with the phorbol ester phorbol 12-myristate 13-acetate were investigated.	Tetradecanoylphorbol Acetate	201-232	protein kinase C, gamma	Rattus norvegicus	163-166
11356008-3	2001	Here, we report that IL-6 and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically transactivate the IRE in HepG2 cells, which is coupled to a strong upregulation of c-Jun and c-Fos expression by TPA via the mitogen-activated protein kinase (MAPK) pathway.	Tetradecanoylphorbol Acetate	30-66	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-187
11356008-3	2001	Here, we report that IL-6 and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically transactivate the IRE in HepG2 cells, which is coupled to a strong upregulation of c-Jun and c-Fos expression by TPA via the mitogen-activated protein kinase (MAPK) pathway.	Tetradecanoylphorbol Acetate	68-71	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-177
11356008-3	2001	Here, we report that IL-6 and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically transactivate the IRE in HepG2 cells, which is coupled to a strong upregulation of c-Jun and c-Fos expression by TPA via the mitogen-activated protein kinase (MAPK) pathway.	Tetradecanoylphorbol Acetate	68-71	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-187
11356008-3	2001	Here, we report that IL-6 and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically transactivate the IRE in HepG2 cells, which is coupled to a strong upregulation of c-Jun and c-Fos expression by TPA via the mitogen-activated protein kinase (MAPK) pathway.	Tetradecanoylphorbol Acetate	202-205	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-177
11356008-3	2001	Here, we report that IL-6 and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically transactivate the IRE in HepG2 cells, which is coupled to a strong upregulation of c-Jun and c-Fos expression by TPA via the mitogen-activated protein kinase (MAPK) pathway.	Tetradecanoylphorbol Acetate	202-205	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-187
11598909-2	2001	Our present results show that fetal calf serum (FCS) and 4 beta-phorbol-12-myristate acetate (PMA) caused an enhancement of phospholipase A(2) (PLA(2)) activity in the membrane fraction of non-confluent cells allowing PLA(2) access to its substrate and the release of AA.	Tetradecanoylphorbol Acetate	94-97	phospholipase A2, group IB, pancreas	Mus musculus	124-142
11598909-2	2001	Our present results show that fetal calf serum (FCS) and 4 beta-phorbol-12-myristate acetate (PMA) caused an enhancement of phospholipase A(2) (PLA(2)) activity in the membrane fraction of non-confluent cells allowing PLA(2) access to its substrate and the release of AA.	Tetradecanoylphorbol Acetate	94-97	phospholipase A2, group IB, pancreas	Mus musculus	144-150
20702295-3	1989	At the non-toxic level of 250 mum, CuSO(4) inhibited by 40% the induction of ornithine decarboxylase by TPA in murine epidermal cultures.	Tetradecanoylphorbol Acetate	104-107	ornithine decarboxylase, structural 1	Mus musculus	77-100
11598909-2	2001	Our present results show that fetal calf serum (FCS) and 4 beta-phorbol-12-myristate acetate (PMA) caused an enhancement of phospholipase A(2) (PLA(2)) activity in the membrane fraction of non-confluent cells allowing PLA(2) access to its substrate and the release of AA.	Tetradecanoylphorbol Acetate	94-97	phospholipase A2, group IB, pancreas	Mus musculus	218-224
11710937-13	2001	Compared with the control, c-fos expression in 12-O-tetradecanoyl-phorbol-13-acetate-treated keratinocytes decreased with age in the thigh, but increased in the photoaged skin of forearm.	Tetradecanoylphorbol Acetate	47-84	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-32
11710937-14	2001	The increased c-fos expression in 12-O-tetradecanoyl-phorbol-13-acetate-treated keratinocytes could be relevant for the predisposition of photoaged keratinocytes to malignant transformation.	Tetradecanoylphorbol Acetate	34-71	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
11278336-12	2001	Bisphenol A diglycidyl ether, a compound that binds to PPARgamma but lacks the ability to activate transcription, also inhibited PMA-mediated induction of AP-1 activity and COX-2.	Tetradecanoylphorbol Acetate	129-132	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	155-159
20702295-7	1989	It appears that oxidants generated in response to TPA partially mediate the induction of ornithine decarboxylase and to a lesser extent DNA synthesis.	Tetradecanoylphorbol Acetate	50-53	ornithine decarboxylase, structural 1	Mus musculus	89-112
11306241-2	2001	One of these compounds, cannabinol (CBN) has been shown to inhibit interleukin-2 (IL-2) expression and the activation of cAMP response element binding protein (CREB) and nuclear factor for immunoglobulin kappa chain in B cells (NF-kappaB) following phorbol-12-myristate-13 acetate (PMA) plus ionomycin (Io) treatment of thymocytes.	Tetradecanoylphorbol Acetate	249-280	cAMP responsive element binding protein 1	Homo sapiens	121-158
11306241-2	2001	One of these compounds, cannabinol (CBN) has been shown to inhibit interleukin-2 (IL-2) expression and the activation of cAMP response element binding protein (CREB) and nuclear factor for immunoglobulin kappa chain in B cells (NF-kappaB) following phorbol-12-myristate-13 acetate (PMA) plus ionomycin (Io) treatment of thymocytes.	Tetradecanoylphorbol Acetate	249-280	cAMP responsive element binding protein 1	Homo sapiens	160-164
11306241-2	2001	One of these compounds, cannabinol (CBN) has been shown to inhibit interleukin-2 (IL-2) expression and the activation of cAMP response element binding protein (CREB) and nuclear factor for immunoglobulin kappa chain in B cells (NF-kappaB) following phorbol-12-myristate-13 acetate (PMA) plus ionomycin (Io) treatment of thymocytes.	Tetradecanoylphorbol Acetate	282-285	cAMP responsive element binding protein 1	Homo sapiens	121-158
11306241-2	2001	One of these compounds, cannabinol (CBN) has been shown to inhibit interleukin-2 (IL-2) expression and the activation of cAMP response element binding protein (CREB) and nuclear factor for immunoglobulin kappa chain in B cells (NF-kappaB) following phorbol-12-myristate-13 acetate (PMA) plus ionomycin (Io) treatment of thymocytes.	Tetradecanoylphorbol Acetate	282-285	cAMP responsive element binding protein 1	Homo sapiens	160-164
11495925-6	2001	We show that the cleavage of fractalkine can be markedly enhanced by stimulating cells with phorbol 12-myristate 13-acetate (PMA), and we identify tumor necrosis factor-alpha converting enzyme (TACE; ADAM17) as the protease responsible for this PMA-induced fractalkine release.	Tetradecanoylphorbol Acetate	245-248	ADAM metallopeptidase domain 17	Homo sapiens	147-192
11495925-6	2001	We show that the cleavage of fractalkine can be markedly enhanced by stimulating cells with phorbol 12-myristate 13-acetate (PMA), and we identify tumor necrosis factor-alpha converting enzyme (TACE; ADAM17) as the protease responsible for this PMA-induced fractalkine release.	Tetradecanoylphorbol Acetate	245-248	ADAM metallopeptidase domain 17	Homo sapiens	194-198
11495925-6	2001	We show that the cleavage of fractalkine can be markedly enhanced by stimulating cells with phorbol 12-myristate 13-acetate (PMA), and we identify tumor necrosis factor-alpha converting enzyme (TACE; ADAM17) as the protease responsible for this PMA-induced fractalkine release.	Tetradecanoylphorbol Acetate	245-248	ADAM metallopeptidase domain 17	Homo sapiens	200-206
20837424-3	1989	At 100 mum-palmitoylcarnitine inhibited TPA-induced ODC by 50% and phospholipase C-induced ODC by 95%.	Tetradecanoylphorbol Acetate	40-43	ornithine decarboxylase, structural 1	Mus musculus	52-55
11678905-4	2001	Following re-stimulation in vitro with PMA and ionomycin, CD4+ T cells produced IFNgamma, TNFalpha, TNFbeta, IL-2, IL-4, IL-10 and IL-13.	Tetradecanoylphorbol Acetate	39-42	lymphotoxin alpha	Homo sapiens	100-107
11678905-4	2001	Following re-stimulation in vitro with PMA and ionomycin, CD4+ T cells produced IFNgamma, TNFalpha, TNFbeta, IL-2, IL-4, IL-10 and IL-13.	Tetradecanoylphorbol Acetate	39-42	interleukin 10	Homo sapiens	121-126
3142956-6	1988	The tumor-promoting phorbol diester, 12-o-tetradecanoyl-phorbol-13-acetate (TPA) also acted synergistically with the three CSFs (IL-3, GM-CSF, and M-CSF) to stimulate the proliferation of BDM-1 cells.	Tetradecanoylphorbol Acetate	37-74	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	135-141
11485830-0	2001	The activation of PI 3-K and PKC zeta in PMA-induced differentiation of HL-60 cells.	Tetradecanoylphorbol Acetate	41-44	protein kinase C zeta	Homo sapiens	29-37
11485830-5	2001	PMA also induced the activation of PKC zeta during monocytic differentiation of HL-60 cells, and LY294002-pretreated cells failed to induce PKC zeta activation.	Tetradecanoylphorbol Acetate	0-3	protein kinase C zeta	Homo sapiens	35-43
11331247-1	2001	The tumor-promoting phorbol ester TPA (12-O-tetradecanoylphorbol-13-acetate) cooperates with c-Src overexpression to transform rat fibroblasts.	Tetradecanoylphorbol Acetate	34-37	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	93-98
11331247-2	2001	TPA transforms c-Src-overexpressing cells by depleting the delta isoform of protein kinase C (PKCdelta).	Tetradecanoylphorbol Acetate	0-3	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	15-20
11485830-7	2001	This implies that activated PI 3-K subsequently stimulates the PKC zeta in the process of PMA-induced monocytic differentiation.	Tetradecanoylphorbol Acetate	90-93	protein kinase C zeta	Homo sapiens	63-71
11388647-6	2001	When phorbol 12-myristate 13-acetate-treated THP-1 and J774A.1 cells were incubated in the medium containing 20% of serum from rats administered R-755, the ACAT activities of the cells were inhibited.	Tetradecanoylphorbol Acetate	5-36	sterol O-acyltransferase 1	Oryctolagus cuniculus	156-160
3142956-6	1988	The tumor-promoting phorbol diester, 12-o-tetradecanoyl-phorbol-13-acetate (TPA) also acted synergistically with the three CSFs (IL-3, GM-CSF, and M-CSF) to stimulate the proliferation of BDM-1 cells.	Tetradecanoylphorbol Acetate	37-74	colony stimulating factor 1 (macrophage)	Mus musculus	136-141
3142956-6	1988	The tumor-promoting phorbol diester, 12-o-tetradecanoyl-phorbol-13-acetate (TPA) also acted synergistically with the three CSFs (IL-3, GM-CSF, and M-CSF) to stimulate the proliferation of BDM-1 cells.	Tetradecanoylphorbol Acetate	76-79	colony stimulating factor 1 (macrophage)	Mus musculus	136-141
11551496-7	2001	Induction of TPA-induced mouse epidermal ornithine decarboxylase (ODC) activity and H(2)O(2)- and UV-induced formation of oxidized DNA bases in vitro were also attenuated by the above compounds.	Tetradecanoylphorbol Acetate	13-16	ornithine decarboxylase, structural 1	Mus musculus	41-64
3057494-6	1988	Transformation by v-src, or treatment with platelet-derived growth factor or phorbol 12-myristate 13-acetate, activated the Raf-1-associated serine/kinase activity as measured in immune-complex kinase assays.	Tetradecanoylphorbol Acetate	77-108	v-raf-leukemia viral oncogene 1	Mus musculus	124-129
11551496-7	2001	Induction of TPA-induced mouse epidermal ornithine decarboxylase (ODC) activity and H(2)O(2)- and UV-induced formation of oxidized DNA bases in vitro were also attenuated by the above compounds.	Tetradecanoylphorbol Acetate	13-16	ornithine decarboxylase, structural 1	Mus musculus	66-69
11549266-0	2001	Phorbol myristate acetate inhibits okadaic acid-induced apoptosis and downregulation of X-linked inhibitor of apoptosis in U937 cells.	Tetradecanoylphorbol Acetate	0-25	X-linked inhibitor of apoptosis	Homo sapiens	88-119
11338405-3	2001	Furthermore, our group demonstrated that UVA enhanced 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated induction of ornithine decarboxylase (ODC) activity in mouse skin (1).	Tetradecanoylphorbol Acetate	54-90	ornithine decarboxylase, structural 1	Mus musculus	119-142
11338405-3	2001	Furthermore, our group demonstrated that UVA enhanced 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated induction of ornithine decarboxylase (ODC) activity in mouse skin (1).	Tetradecanoylphorbol Acetate	54-90	ornithine decarboxylase, structural 1	Mus musculus	144-147
11338405-3	2001	Furthermore, our group demonstrated that UVA enhanced 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated induction of ornithine decarboxylase (ODC) activity in mouse skin (1).	Tetradecanoylphorbol Acetate	92-95	ornithine decarboxylase, structural 1	Mus musculus	119-142
11338405-3	2001	Furthermore, our group demonstrated that UVA enhanced 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated induction of ornithine decarboxylase (ODC) activity in mouse skin (1).	Tetradecanoylphorbol Acetate	92-95	ornithine decarboxylase, structural 1	Mus musculus	144-147
11338405-11	2001	UVA slightly enhanced TPA-mediated ODC mRNA induction, while it enhanced ODC enzyme activity 70%.	Tetradecanoylphorbol Acetate	22-25	ornithine decarboxylase, structural 1	Mus musculus	35-38
3196353-1	1988	When applied 5 min either before or after treatment with TPA, 1 microgram of staurosporine cause about 56% inhibition of ODC-induction by 5 micrograms of TPA.	Tetradecanoylphorbol Acetate	57-60	ornithine decarboxylase, structural 1	Mus musculus	121-124
11310793-8	2001	Studies using inhibitors for protein kinases involved in cell signaling pathways suggested that stress-activated kinase p38 and mitogen-activated protein kinase kinase MEK are involved in TPA-independent regulation of TYRP2 expression in melanocytes.	Tetradecanoylphorbol Acetate	188-191	dopachrome tautomerase	Homo sapiens	218-223
11124968-0	2001	CD45 negatively regulates monocytic cell differentiation by inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase Cdelta.	Tetradecanoylphorbol Acetate	71-102	protein tyrosine phosphatase receptor type C	Homo sapiens	0-4
11124968-2	2001	Here we report that CD45 negatively regulates monocyte differentiation by inhibiting phorbol 12-myristate 13-acetate (PMA)-dependent activation of protein kinase C (PKC) delta.	Tetradecanoylphorbol Acetate	85-116	protein tyrosine phosphatase receptor type C	Homo sapiens	20-24
11587160-9	2001	Stimulation with PMA caused more rapid activation in EHT neutrophils with expression of CD11b, followed rapidly by exocytosis of primary granules.	Tetradecanoylphorbol Acetate	17-20	integrin subunit alpha M	Homo sapiens	88-93
11477572-11	2001	Despite long-term papilloma inhibition in both PKC delta and PKC epsilon transgenic mice, the induction of ODC by TPA was not attenuated in PKC delta and epsilon mouse lines.	Tetradecanoylphorbol Acetate	114-117	ornithine decarboxylase, structural 1	Mus musculus	107-110
11477572-14	2001	TPA-induced ODC activity and the resultant accumulation of polyamines may play different roles (e.g., induction of apoptosis vs. proliferation) in the pathways leading to the induction of cancer in PKC alpha, PKC delta and PKC epsilon transgenic mice.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	12-15
11477572-14	2001	TPA-induced ODC activity and the resultant accumulation of polyamines may play different roles (e.g., induction of apoptosis vs. proliferation) in the pathways leading to the induction of cancer in PKC alpha, PKC delta and PKC epsilon transgenic mice.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, delta	Mus musculus	209-218
3196353-1	1988	When applied 5 min either before or after treatment with TPA, 1 microgram of staurosporine cause about 56% inhibition of ODC-induction by 5 micrograms of TPA.	Tetradecanoylphorbol Acetate	154-157	ornithine decarboxylase, structural 1	Mus musculus	121-124
11509614-2	2001	We have found that a greater induction in HIV-1 long terminal repeat-driven gene expression was observed upon PMA/ionomycin (Iono) stimulation of a CD45-deficient cell line (J45.01) in comparison to the parental Jurkat cells.	Tetradecanoylphorbol Acetate	110-113	protein tyrosine phosphatase receptor type C	Homo sapiens	148-152
3141077-1	1988	Recent work from this laboratory has demonstrated the presence of a structurally and functionally different ornithine decarboxylase (ODC) in mouse epidermal tumors induced by a two-stage protocol involving initiation with 7,12-dimethylbenzanthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	314-317	ornithine decarboxylase, structural 1	Mus musculus	133-136
2849413-4	1988	Pretreatment with phorbol 12-myristate 13-acetate (PMA) for 20 min inhibited the ability of [Tyr4]bombesin to induce phosphatidylinositol (PtdIns) turnover and to increase intracellular free Ca2+ ([Ca2+]i).	Tetradecanoylphorbol Acetate	18-49	gastrin releasing peptide	Homo sapiens	98-106
11547349-12	2001	Introducing 100 mm inhibitor into the DF reduced J(HCO3) to approximately 20 pmole cm(-2) sec(-1) for tetramethylammonium (TMA(+)), approximately 24 for TEA(+), approximately 10 for tetrapropylammonium (TPA(+)), and virtually zero for tetrabutylammonium (TBA(+)).	Tetradecanoylphorbol Acetate	203-206	secretory blood group 1, pseudogene	Homo sapiens	90-96
11564170-5	2001	Transcriptional activation of BSSP by 12-O-tetradecanoylphorbol-13-acetate was found to be independent of c-Fos expression and resistant to downregulation by glucocorticoids.	Tetradecanoylphorbol Acetate	38-74	kallikrein related-peptidase 6	Mus musculus	30-34
11169972-0	2001	Modulation of cyclin D1 and its signaling components by the phorbol ester TPA and the tyrosine phosphatase inhibitor vanadate.	Tetradecanoylphorbol Acetate	74-77	cyclin D1	Mus musculus	14-23
11169972-2	2001	TPA treatment resulted in a temporary induction of cyclin D1 peaking at 9 h post stimulation.	Tetradecanoylphorbol Acetate	0-3	cyclin D1	Mus musculus	51-60
11169972-3	2001	PD98059 (10 microM), the specific inhibitor of MAPK kinase, completely blocked TPA-stimulated cyclin D1 induction and DNA synthesis, confirming that MAPK activation plays an essential role in TPA-stimulated cell-cycle progression.	Tetradecanoylphorbol Acetate	79-82	cyclin D1	Mus musculus	94-103
11169972-3	2001	PD98059 (10 microM), the specific inhibitor of MAPK kinase, completely blocked TPA-stimulated cyclin D1 induction and DNA synthesis, confirming that MAPK activation plays an essential role in TPA-stimulated cell-cycle progression.	Tetradecanoylphorbol Acetate	192-195	cyclin D1	Mus musculus	94-103
11169972-5	2001	p70s6K, an important kinase involved in the regulation of protein synthesis and cell-cycle progression, has been reported to be activated through a PKC-dependent pathway (TPA-activatable) in addition to a PI3K-dependent pathway.	Tetradecanoylphorbol Acetate	171-174	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	0-6
2849413-4	1988	Pretreatment with phorbol 12-myristate 13-acetate (PMA) for 20 min inhibited the ability of [Tyr4]bombesin to induce phosphatidylinositol (PtdIns) turnover and to increase intracellular free Ca2+ ([Ca2+]i).	Tetradecanoylphorbol Acetate	51-54	gastrin releasing peptide	Homo sapiens	98-106
11169972-6	2001	Here, we demonstrate for the first time that TPA-stimulated MAPK activation is essential for the phosphorylation of several key residues involved in the activation of p70s6K, namely, thr389, thr421, and ser424.	Tetradecanoylphorbol Acetate	45-48	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	167-173
11514958-4	2001	Basal and phorbol myristate acetate (PMA)-stimulated oxidative burst and CD11b expression were determined using dihydrorhodamine 123 and phycoerythrin (PE)-conjugated anti-CD11b monoclonal antibodies.	Tetradecanoylphorbol Acetate	37-40	integrin subunit alpha M	Homo sapiens	73-78
11514958-4	2001	Basal and phorbol myristate acetate (PMA)-stimulated oxidative burst and CD11b expression were determined using dihydrorhodamine 123 and phycoerythrin (PE)-conjugated anti-CD11b monoclonal antibodies.	Tetradecanoylphorbol Acetate	37-40	integrin subunit alpha M	Homo sapiens	172-177
2849413-5	1988	Pretreatment with PMA for 48 h attenuated the ability of subsequently added PMA to decrease the response to [Tyr4]bombesin.	Tetradecanoylphorbol Acetate	18-21	gastrin releasing peptide	Homo sapiens	114-122
2849413-5	1988	Pretreatment with PMA for 48 h attenuated the ability of subsequently added PMA to decrease the response to [Tyr4]bombesin.	Tetradecanoylphorbol Acetate	76-79	gastrin releasing peptide	Homo sapiens	114-122
11494368-5	2001	A PKC activator, phorbol-12-myristate-13-acetate, enhanced the secretion of BDNF.	Tetradecanoylphorbol Acetate	17-48	protein kinase C, alpha	Rattus norvegicus	2-5
3139753-1	1988	We have previously shown that Lyt-2- L3T4- T cells from the lymph nodes of MRL/lpr/lpr mice could respond to 12-O-tetradecanoylphorbol-2-acetate (TPA) and A23187 by proliferation, IL-2 secretion, and IL-2R (IL-2R) expression.	Tetradecanoylphorbol Acetate	146-149	interleukin 2 receptor, alpha chain	Mus musculus	200-205
11494368-5	2001	A PKC activator, phorbol-12-myristate-13-acetate, enhanced the secretion of BDNF.	Tetradecanoylphorbol Acetate	17-48	brain-derived neurotrophic factor	Rattus norvegicus	76-80
11261799-6	2001	When stimulated by phorbol 12-myristate 13-acetate (PMA), Lsp1-/- peritoneal neutrophils produce more superoxide than WT.	Tetradecanoylphorbol Acetate	19-50	lymphocyte specific 1	Mus musculus	58-62
11261799-6	2001	When stimulated by phorbol 12-myristate 13-acetate (PMA), Lsp1-/- peritoneal neutrophils produce more superoxide than WT.	Tetradecanoylphorbol Acetate	52-55	lymphocyte specific 1	Mus musculus	58-62
2842422-5	1988	Addition of RA or the tumor promoter, phorbol 12-myristic 13-acetate (PMA), to HPBM or THP-1 cells resulted in significant increases in 5NT activity with opposite effects on ADA activity.	Tetradecanoylphorbol Acetate	70-73	adenosine deaminase	Homo sapiens	174-177
11411021-5	2001	RESULTS: Phorbol-12-myristate-13-acetate significantly upregulated the nephrin expression in A293 cells, while no change was found after treatment with additional stimulants for other main signalling pathways, e.g. okadaic acid, lysophosphatidic acid, bradykinin, angiotensin II (ANG II) and arginine vasopressin (AVP).	Tetradecanoylphorbol Acetate	9-40	NPHS1 adhesion molecule, nephrin	Homo sapiens	71-78
11226521-4	2001	Promoter deletion analyses revealed that the activator protein-1 (AP-1) transcription factor site was crucial for 12-O-tetradecanoyl phorbol 13-acetate (TPA)-mediated GSTP1 gene transcription.	Tetradecanoylphorbol Acetate	114-151	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-64
11476900-2	2001	In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (PMA) have been reported to differentiate into CD4 single positive cells.	Tetradecanoylphorbol Acetate	139-170	CD4 antigen	Mus musculus	21-24
11476900-2	2001	In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (PMA) have been reported to differentiate into CD4 single positive cells.	Tetradecanoylphorbol Acetate	139-170	CD4 antigen	Mus musculus	218-221
11476900-2	2001	In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (PMA) have been reported to differentiate into CD4 single positive cells.	Tetradecanoylphorbol Acetate	172-175	CD4 antigen	Mus musculus	21-24
11476900-2	2001	In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (PMA) have been reported to differentiate into CD4 single positive cells.	Tetradecanoylphorbol Acetate	172-175	CD4 antigen	Mus musculus	218-221
3135941-2	1988	fos protein (p55fos) is associated with other nuclear proteins in complexes that bind to regulatory regions containing TPA-responsive promoter elements (TREs).	Tetradecanoylphorbol Acetate	119-122	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-3
11587480-0	2001	Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	181-217	ATP binding cassette subfamily C member 2	Homo sapiens	81-85
11435343-4	2001	Methods and Results-PKC was downregulated by prolonged (24-hour) treatment with phorbol 12-myristate 13-acetate (4 microgram/kg body weight) before subsequent experiments in rats.	Tetradecanoylphorbol Acetate	80-111	protein kinase C, alpha	Rattus norvegicus	20-23
11431495-8	2001	On the other hand, the phorbol ester phorbol 12-myristate 13-acetate (PMA), which does not affect TASK-1, produces strong inhibition of KT3.2 currents.	Tetradecanoylphorbol Acetate	37-68	potassium two pore domain channel subfamily K member 9	Homo sapiens	136-141
11431495-8	2001	On the other hand, the phorbol ester phorbol 12-myristate 13-acetate (PMA), which does not affect TASK-1, produces strong inhibition of KT3.2 currents.	Tetradecanoylphorbol Acetate	70-73	potassium two pore domain channel subfamily K member 9	Homo sapiens	136-141
11500965-3	2001	Since PKC can activate extracellular signal regulated kinases (ERKs) and these also downregulate GJIC, we hypothesized that the inhibition of GJIC by TPA involved ERKs.	Tetradecanoylphorbol Acetate	150-153	protein kinase C, gamma	Rattus norvegicus	6-9
11500965-6	2001	These data suggest that ERKs are activated by PKC in response to TPA treatment and are downstream mediators of the gap junction effects of the phorbol ester.	Tetradecanoylphorbol Acetate	65-68	protein kinase C, gamma	Rattus norvegicus	46-49
11331069-3	2001	To elucidate the role of protein kinase C in the regulation of MDR3 gene expression, we investigated the effect of phorbol 12-myristate 13-acetate (PMA) on the level of MDR3 mRNA in human Chang liver cells by a reverse transcription-polymerase chain reaction method.	Tetradecanoylphorbol Acetate	115-146	ATP binding cassette subfamily B member 4	Homo sapiens	169-173
11331069-3	2001	To elucidate the role of protein kinase C in the regulation of MDR3 gene expression, we investigated the effect of phorbol 12-myristate 13-acetate (PMA) on the level of MDR3 mRNA in human Chang liver cells by a reverse transcription-polymerase chain reaction method.	Tetradecanoylphorbol Acetate	148-151	ATP binding cassette subfamily B member 4	Homo sapiens	169-173
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	54-85	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	159-166
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	54-85	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	167-171
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	54-85	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	159-162
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	87-90	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	159-166
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	87-90	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	167-171
11374877-3	2001	Treatment of mouse primary keratinocyte cultures with phorbol-12-myristate-13-acetate (PMA) reduced DNA synthesis and sequentially induced an up-regulation of p21Cip1/WAF1 (p21), hr and involucrin (inv) mRNAs in a time-dependent fashion, suggesting that an increase in hr gene expression is associated with keratinocyte differentiation.	Tetradecanoylphorbol Acetate	87-90	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	159-162
11407309-0	2001	Induction of CD4+ regulatory T cells by 12-O-tetradecanoylphorbol 13-acetate in mice.	Tetradecanoylphorbol Acetate	40-76	CD4 antigen	Mus musculus	13-16
11407309-4	2001	TPA painting induced CD4+Tr cells in C3H/He (H-2k), C3H/HeN (H-2k), DBA/2 (H-2d) and AKR/N (H-2k) mice, but not in C57BL/6 (H-2b), C57BL/10 (H-2b), BALB/c (H-2d) and A/J (H-2a).	Tetradecanoylphorbol Acetate	0-3	CD4 antigen	Mus musculus	21-24
11334627-4	2001	Both PKC isoforms of BLM are functional since a protein kinase C activator, TPA, increased the total hydroxylamine-resistant 32P(i) incorporation from [gamma-32P]ATP into the BLM.	Tetradecanoylphorbol Acetate	76-79	protein kinase D1	Homo sapiens	5-8
11334627-5	2001	In parallel, TPA stimulated the Na(+)-ATPase activity from BLM in a dose-dependent manner, the effect being reversed by the PKC inhibitor sphingosine.	Tetradecanoylphorbol Acetate	13-16	protein kinase D1	Homo sapiens	124-127
11465087-4	2001	Moreover, stimulation with phorbol 12-myristate 13-acetate increased endocytosis of IgM-coated microparticles mediated by the Fc alpha/mu receptor expressed on pro-B cell line Ba/F3 cells.	Tetradecanoylphorbol Acetate	27-58	immunoglobulin heavy constant mu	Mus musculus	84-87
11699875-8	2001	The PKC inhibitor, Go6976, which only inhibits conventional PKCalpha and _, suppressed TPA-induced glucose uptake, but suppressed insulin-induced glucose uptake to only a small extent.	Tetradecanoylphorbol Acetate	87-90	protein kinase C, alpha	Rattus norvegicus	4-7
11699875-9	2001	On the other hand, the PKC inhibitor, RO32-0432, which inhibits conventional, novel, and atypical PKCs, markedly suppressed both insulin- and TPA-induced glucose uptake.	Tetradecanoylphorbol Acetate	142-145	protein kinase C, alpha	Rattus norvegicus	23-26
11333365-6	2001	Further in vitro study showed that NAMDA potentiated phorbol-12 myristate-13 acetate (PMA)-induced c-Fos expression, AP1 binding activity, and late gene expression determined by chloramphenicol acetyltransferase (CAT) activity from AP1 containing tyrosine hydroxylase promoter-CAT fusion gene in SK-N-BE(2)C neurons.	Tetradecanoylphorbol Acetate	53-84	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	99-104
11333365-6	2001	Further in vitro study showed that NAMDA potentiated phorbol-12 myristate-13 acetate (PMA)-induced c-Fos expression, AP1 binding activity, and late gene expression determined by chloramphenicol acetyltransferase (CAT) activity from AP1 containing tyrosine hydroxylase promoter-CAT fusion gene in SK-N-BE(2)C neurons.	Tetradecanoylphorbol Acetate	86-89	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	99-104
11288147-8	2001	Finally, although the protein kinase C stimulator phorbol-12-myristate-13-acetate enhanced EAAT2 mRNA levels after hypoxia, protein kinase C inhibitor bisindolylmaleimide I had the opposite effect.	Tetradecanoylphorbol Acetate	50-81	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	91-96
11405060-6	2001	uPAR in phorbol-12-myristate-13-acetate-stimulated chondrocytes colocalized with caveolin as well as beta 1-integrin, as demonstrated by double immunostaining with specific antibodies.	Tetradecanoylphorbol Acetate	8-39	integrin subunit beta 1	Homo sapiens	101-116
11338405-13	2001	alpha-Tocopherol pretreatment inhibited the induction of ODC enzyme activity by TPA treatment combined with UVA exposure (TPA + UVA); however, alpha-tocopherol had less of an inhibitory effect on ODC mRNA induction by TPA + UVA.	Tetradecanoylphorbol Acetate	80-83	ornithine decarboxylase, structural 1	Mus musculus	57-60
11338405-13	2001	alpha-Tocopherol pretreatment inhibited the induction of ODC enzyme activity by TPA treatment combined with UVA exposure (TPA + UVA); however, alpha-tocopherol had less of an inhibitory effect on ODC mRNA induction by TPA + UVA.	Tetradecanoylphorbol Acetate	122-125	ornithine decarboxylase, structural 1	Mus musculus	57-60
11338405-13	2001	alpha-Tocopherol pretreatment inhibited the induction of ODC enzyme activity by TPA treatment combined with UVA exposure (TPA + UVA); however, alpha-tocopherol had less of an inhibitory effect on ODC mRNA induction by TPA + UVA.	Tetradecanoylphorbol Acetate	122-125	ornithine decarboxylase, structural 1	Mus musculus	57-60
11338405-14	2001	Curcumin, a plant pigment, dramatically inhibited both TPA- and TPA + UVA-induced expression of ODC and MT genes.	Tetradecanoylphorbol Acetate	55-58	ornithine decarboxylase, structural 1	Mus musculus	96-99
11338405-14	2001	Curcumin, a plant pigment, dramatically inhibited both TPA- and TPA + UVA-induced expression of ODC and MT genes.	Tetradecanoylphorbol Acetate	64-67	ornithine decarboxylase, structural 1	Mus musculus	96-99
11338405-15	2001	CONCLUSIONS: These results demonstrate that UVA can induce MT gene expression and enhance TPA-induced ODC and MT gene expression.	Tetradecanoylphorbol Acetate	90-93	ornithine decarboxylase, structural 1	Mus musculus	102-105
12687202-4	2001	CsA downregulates PMA/ionomycin-induced LTalpha at both transcription and protein expression levels, whereas it downregulates LTbeta at the transcript but not at the protein expression levels.	Tetradecanoylphorbol Acetate	18-21	lymphotoxin alpha	Homo sapiens	40-47
11124968-2	2001	Here we report that CD45 negatively regulates monocyte differentiation by inhibiting phorbol 12-myristate 13-acetate (PMA)-dependent activation of protein kinase C (PKC) delta.	Tetradecanoylphorbol Acetate	118-121	protein tyrosine phosphatase receptor type C	Homo sapiens	20-24
11124968-4	2001	In addition, reduction in CD45 expression caused the duration of peak PMA-induced MEK and extracellular signal-regulated kinase (ERK) 1/2 activity to increase from 5 min to 30 min while leading to a 4-fold increase in PMA-dependent PKCdelta activation.	Tetradecanoylphorbol Acetate	70-73	protein tyrosine phosphatase receptor type C	Homo sapiens	26-30
11124968-4	2001	In addition, reduction in CD45 expression caused the duration of peak PMA-induced MEK and extracellular signal-regulated kinase (ERK) 1/2 activity to increase from 5 min to 30 min while leading to a 4-fold increase in PMA-dependent PKCdelta activation.	Tetradecanoylphorbol Acetate	218-221	protein tyrosine phosphatase receptor type C	Homo sapiens	26-30
11250869-4	2001	When expressed in Xenopus laevis oocytes, hCAT-1-mediated L-arginine transport was reduced to 44+/-3% after a 30 min treatment of the oocytes with 100 nM phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	154-185	solute carrier family 7 member 1	Homo sapiens	42-48
11250869-4	2001	When expressed in Xenopus laevis oocytes, hCAT-1-mediated L-arginine transport was reduced to 44+/-3% after a 30 min treatment of the oocytes with 100 nM phorbol-12-myristate-13-acetate (PMA).	Tetradecanoylphorbol Acetate	187-190	solute carrier family 7 member 1	Homo sapiens	42-48
11250869-7	2001	In EA.hy926 endothelial cells, maximal inhibition of hCAT-1-mediated L-arginine transport (to 3 -- 11% of control) was observed after treatment of the cells with 100 nM PMA for 4 h. A 20 -- 30 h exposure of the cells to 100 nM PMA led to the recovery of the L-arginine uptake rate that was now resistant to a second application of PMA.	Tetradecanoylphorbol Acetate	169-172	solute carrier family 7 member 1	Homo sapiens	53-59
11250869-7	2001	In EA.hy926 endothelial cells, maximal inhibition of hCAT-1-mediated L-arginine transport (to 3 -- 11% of control) was observed after treatment of the cells with 100 nM PMA for 4 h. A 20 -- 30 h exposure of the cells to 100 nM PMA led to the recovery of the L-arginine uptake rate that was now resistant to a second application of PMA.	Tetradecanoylphorbol Acetate	227-230	solute carrier family 7 member 1	Homo sapiens	53-59
11250869-7	2001	In EA.hy926 endothelial cells, maximal inhibition of hCAT-1-mediated L-arginine transport (to 3 -- 11% of control) was observed after treatment of the cells with 100 nM PMA for 4 h. A 20 -- 30 h exposure of the cells to 100 nM PMA led to the recovery of the L-arginine uptake rate that was now resistant to a second application of PMA.	Tetradecanoylphorbol Acetate	227-230	solute carrier family 7 member 1	Homo sapiens	53-59
11312897-10	2001	All test samples were positive for inhibition of TPA-induced free radical formation on neutrophil-like leukocytes and were found to follow the order AHM &gt; ATM &gt; ABM &gt; PAM.	Tetradecanoylphorbol Acetate	49-52	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	176-179
11487146-7	2001	The present results suggested that TNF-alpha stimulates PA activity via an enhancement of tPA gene expression in HDP cells and MMP-2 activity, and further that tPA-activated TNF-alpha stimulated MMP-9.	Tetradecanoylphorbol Acetate	160-163	matrix metallopeptidase 9	Homo sapiens	195-200
11224528-3	2001	Expression of B7-H3 protein, however, can be induced on dendritic cells (DCs) and monocytes by inflammatory cytokines and a combination of phorbol myristate acetate (PMA) + ionomycin.	Tetradecanoylphorbol Acetate	139-164	CD276 antigen	Mus musculus	14-19
11224528-3	2001	Expression of B7-H3 protein, however, can be induced on dendritic cells (DCs) and monocytes by inflammatory cytokines and a combination of phorbol myristate acetate (PMA) + ionomycin.	Tetradecanoylphorbol Acetate	166-169	CD276 antigen	Mus musculus	14-19
11238950-5	2001	We also found that the Rac1-GTP level decreased after stimulation with TPA and that the Rac1-IQGAP1 complexes decreased, while the IQGAP1-beta-catenin complexes increased during action of TPA.	Tetradecanoylphorbol Acetate	188-191	catenin beta 1	Canis lupus familiaris	138-150
11181442-5	2001	Thus, total PKC activity does not indicate absolute sensitivity of a cell system to TPA-induced suppression of communication, but within a certain cell system increasing PKC activity may enhance the sensitivity to TPA in this respect.	Tetradecanoylphorbol Acetate	214-217	protein kinase C, alpha	Rattus norvegicus	170-173
11181442-9	2001	Long-term treatment with TPA caused strong down-regulation of PKC alpha, delta and epsilon, but little down-regulation of PKC mu.	Tetradecanoylphorbol Acetate	25-28	protein kinase C, alpha	Rattus norvegicus	62-90
11158244-7	2001	PMA treatment also produced an increase in the phosphorylation of serine 890 on the NR1 subunit, a known PKC site, at 5 min with phosphorylation returning to near basal levels by 10 min while tyrosine phosphorylation of NR2A and NR2B was sustained for up to 15 min.	Tetradecanoylphorbol Acetate	0-3	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	229-233
11152592-9	2001	The latter regulated reporter gene activity stronger in response to PMA (phorbol 12-myristate 13-acetate) stimulation and were used to construct HF1 reporter cell lines.	Tetradecanoylphorbol Acetate	68-71	complement factor H	Homo sapiens	145-148
11152592-9	2001	The latter regulated reporter gene activity stronger in response to PMA (phorbol 12-myristate 13-acetate) stimulation and were used to construct HF1 reporter cell lines.	Tetradecanoylphorbol Acetate	73-104	complement factor H	Homo sapiens	145-148
11145705-2	2001	In bone marrow (BM) neutrophils isolated from rac2(-/-) mice generated by gene targeting, we previously reported that PMA-induced superoxide production was reduced by about 4-fold, which was partially corrected in TNF-alpha-primed BM neutrophils and in peritoneal exudate neutrophils.	Tetradecanoylphorbol Acetate	118-121	Rac family small GTPase 2	Mus musculus	46-50
11226521-4	2001	Promoter deletion analyses revealed that the activator protein-1 (AP-1) transcription factor site was crucial for 12-O-tetradecanoyl phorbol 13-acetate (TPA)-mediated GSTP1 gene transcription.	Tetradecanoylphorbol Acetate	114-151	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-70
11226521-4	2001	Promoter deletion analyses revealed that the activator protein-1 (AP-1) transcription factor site was crucial for 12-O-tetradecanoyl phorbol 13-acetate (TPA)-mediated GSTP1 gene transcription.	Tetradecanoylphorbol Acetate	153-156	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-64
11226521-4	2001	Promoter deletion analyses revealed that the activator protein-1 (AP-1) transcription factor site was crucial for 12-O-tetradecanoyl phorbol 13-acetate (TPA)-mediated GSTP1 gene transcription.	Tetradecanoylphorbol Acetate	153-156	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-70
11226521-5	2001	Electrophoretic mobility shift assays and transient transfection analysis demonstrated that both DNA binding and transactivation activities of AP-1 were induced by TPA.	Tetradecanoylphorbol Acetate	164-167	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	143-147
11159837-7	2001	Activation of the PKA and PKC pathways by 10 microM forskolin and 1 microM PMA, respectively, induced Nurr1 mRNA levels.	Tetradecanoylphorbol Acetate	75-78	nuclear receptor subfamily 4, group A, member 2	Mus musculus	102-107
11179965-9	2001	In contrast, enforced tPACRE-binding activity of CREB in HeLa cells significantly reduced the magnitude of PMA-mediated induction of t-PA mRNA in HeLa cells.	Tetradecanoylphorbol Acetate	107-110	cAMP responsive element binding protein 1	Homo sapiens	49-53
11152521-12	2001	Finally, K8 was also found to accumulate in functional viral RC, detected by incorporation of pulse-labeled bromodeoxyuridine into newly synthesized DNA in both tetradecanoyl phorbol acetate-induced JSC-1 primary effusion lymphoblasts and in KSHV lytically infected endothelial cells.	Tetradecanoylphorbol Acetate	161-190	K8	Human gammaherpesvirus 8	9-11
11241758-3	2001	The data showed that a A(182)--&gt;T transversion in the c-Ha-ras gene was present in 100% and 81% of the skin tumors developed in Car-S and Car-R mice, respectively, after DMBA initiation and TPA promotion, suggesting that differences in genetic susceptibility can influence the frequency of c-Ha-ras mutations in the skin tumors produced.	Tetradecanoylphorbol Acetate	193-196	Harvey rat sarcoma virus oncogene	Mus musculus	57-65
11235918-6	2001	Increased ODC gene and SAMDC gene expression in response to phorbol-12-myristate-13-acetate (PMA) treatment was found to involve transcriptional events in both NR3 cells and in C2 cells.	Tetradecanoylphorbol Acetate	60-91	ornithine decarboxylase, structural 1	Mus musculus	10-13
11235918-6	2001	Increased ODC gene and SAMDC gene expression in response to phorbol-12-myristate-13-acetate (PMA) treatment was found to involve transcriptional events in both NR3 cells and in C2 cells.	Tetradecanoylphorbol Acetate	60-91	S-adenosylmethionine decarboxylase 1	Mus musculus	23-28
11235918-6	2001	Increased ODC gene and SAMDC gene expression in response to phorbol-12-myristate-13-acetate (PMA) treatment was found to involve transcriptional events in both NR3 cells and in C2 cells.	Tetradecanoylphorbol Acetate	93-96	ornithine decarboxylase, structural 1	Mus musculus	10-13
11235918-6	2001	Increased ODC gene and SAMDC gene expression in response to phorbol-12-myristate-13-acetate (PMA) treatment was found to involve transcriptional events in both NR3 cells and in C2 cells.	Tetradecanoylphorbol Acetate	93-96	S-adenosylmethionine decarboxylase 1	Mus musculus	23-28
11560763-1	2001	BACKGROUND: Phorbol 12-myristate 13-acetate (PMA) is often used as an activating phorbol ester of protein kinase C (PKC) to investigate the roles of the kinase in cellular functions.	Tetradecanoylphorbol Acetate	12-43	protein kinase C, gamma	Rattus norvegicus	98-114
11560763-1	2001	BACKGROUND: Phorbol 12-myristate 13-acetate (PMA) is often used as an activating phorbol ester of protein kinase C (PKC) to investigate the roles of the kinase in cellular functions.	Tetradecanoylphorbol Acetate	12-43	protein kinase C, gamma	Rattus norvegicus	116-119
11560763-1	2001	BACKGROUND: Phorbol 12-myristate 13-acetate (PMA) is often used as an activating phorbol ester of protein kinase C (PKC) to investigate the roles of the kinase in cellular functions.	Tetradecanoylphorbol Acetate	45-48	protein kinase C, gamma	Rattus norvegicus	98-114
11560763-1	2001	BACKGROUND: Phorbol 12-myristate 13-acetate (PMA) is often used as an activating phorbol ester of protein kinase C (PKC) to investigate the roles of the kinase in cellular functions.	Tetradecanoylphorbol Acetate	45-48	protein kinase C, gamma	Rattus norvegicus	116-119
11560763-4	2001	RESULTS: In current-clamp recording, PMA (80 nM) reversibly inhibited 15 mM glucose-induced action potential spikes superimposed on a slow membrane depolarization and this inhibition can not be prevented by pre-treatment of the cell with a specific PKC inhibitor, bisindolylmaleimide (BIM, 1 microM).	Tetradecanoylphorbol Acetate	37-40	protein kinase C, gamma	Rattus norvegicus	249-252
11913958-4	2001	Treatment with 12-o-tetradecanoyl phorbol-13-acetate (TPA), a protein kinase C (PKC) activator, resulted in an increased secretion of PAcP in a dose- and time-dependent fashion.	Tetradecanoylphorbol Acetate	15-52	acid phosphatase 3	Homo sapiens	134-138
11913958-4	2001	Treatment with 12-o-tetradecanoyl phorbol-13-acetate (TPA), a protein kinase C (PKC) activator, resulted in an increased secretion of PAcP in a dose- and time-dependent fashion.	Tetradecanoylphorbol Acetate	54-57	acid phosphatase 3	Homo sapiens	134-138
11913958-6	2001	This TPA stimulation of PAcP secretion was observed 2 h after exposure, while TPA did not have a significant effect on the mRNA level even with a 6 h treatment.	Tetradecanoylphorbol Acetate	5-8	acid phosphatase 3	Homo sapiens	24-28
11913958-8	2001	This TPA stimulation of PAcP secretion was more potent than the conventional stimulating agent 5alpha-dihydrotestosterone (DHT) at the same concentration of 50 nM.	Tetradecanoylphorbol Acetate	5-8	acid phosphatase 3	Homo sapiens	24-28
11913958-9	2001	Furthermore, the action of TPA and DHT on PAcP secretion was blocked by five different PKC inhibitors.	Tetradecanoylphorbol Acetate	27-30	acid phosphatase 3	Homo sapiens	42-46
11746513-6	2001	Ank gene expression is also upregulated after treating quiescent fibroblasts with several other mitogenic agents (e.g., calf serum or platelet-derived growth factor-BB) or the tumor promoter phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	191-222	progressive ankylosis	Mus musculus	0-3
11384880-11	2001	Furthermore, we showed that the PKC activator phorbol-12-myristate-13-acetate (PMA) also potentiated the IL-4-induced 3beta-HSD activity, thus suggesting that one signaling molecule that is involved in the signal transduction of the IL-4 action on 3beta-HSD type 1 expression is also a substrate for PKC.	Tetradecanoylphorbol Acetate	46-77	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	118-127
11384880-11	2001	Furthermore, we showed that the PKC activator phorbol-12-myristate-13-acetate (PMA) also potentiated the IL-4-induced 3beta-HSD activity, thus suggesting that one signaling molecule that is involved in the signal transduction of the IL-4 action on 3beta-HSD type 1 expression is also a substrate for PKC.	Tetradecanoylphorbol Acetate	46-77	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	248-257
11384880-11	2001	Furthermore, we showed that the PKC activator phorbol-12-myristate-13-acetate (PMA) also potentiated the IL-4-induced 3beta-HSD activity, thus suggesting that one signaling molecule that is involved in the signal transduction of the IL-4 action on 3beta-HSD type 1 expression is also a substrate for PKC.	Tetradecanoylphorbol Acetate	79-82	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	118-127
11384880-11	2001	Furthermore, we showed that the PKC activator phorbol-12-myristate-13-acetate (PMA) also potentiated the IL-4-induced 3beta-HSD activity, thus suggesting that one signaling molecule that is involved in the signal transduction of the IL-4 action on 3beta-HSD type 1 expression is also a substrate for PKC.	Tetradecanoylphorbol Acetate	79-82	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	248-257
10995778-8	2000	Induction of SAA by phorbol 12-myristate 13-acetate, a known agonist of protein kinase C (PKC), suggested a potential role of the PKC signaling pathway in the activation process.	Tetradecanoylphorbol Acetate	20-51	serum amyloid A1 cluster	Homo sapiens	13-16
11190776-6	2000	moderately reduced PLA2 activity in TPA-induced mouse ear inflammation test.	Tetradecanoylphorbol Acetate	36-39	phospholipase A2, group IB, pancreas	Mus musculus	19-23
11095914-8	2000	Activation of classical and novel PKC isozymes by phorbol 12-myristate 13-acetate and phorbol 12,13-dibutyrate stimulated goblet cell glycoprotein secretion.	Tetradecanoylphorbol Acetate	50-81	protein kinase C, alpha	Rattus norvegicus	34-37
11146165-10	2000	Expression of CD41, a differentiation-related phenotype, was significantly induced by TPA after 7 days of treatment, showing that functional maturation was mainly induced by TPA.	Tetradecanoylphorbol Acetate	86-89	integrin subunit alpha 2b	Homo sapiens	14-18
11146165-10	2000	Expression of CD41, a differentiation-related phenotype, was significantly induced by TPA after 7 days of treatment, showing that functional maturation was mainly induced by TPA.	Tetradecanoylphorbol Acetate	174-177	integrin subunit alpha 2b	Homo sapiens	14-18
11121152-6	2000	Atopic dermatitis keratinocyte nuclear lysates had higher constitutive levels of c-Jun, and phorbol myristate acetate promoted an earlier and stronger expression of c-Jun, JunB, and of the phosphorylated forms of c-Fos.	Tetradecanoylphorbol Acetate	92-117	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	165-170
11121152-6	2000	Atopic dermatitis keratinocyte nuclear lysates had higher constitutive levels of c-Jun, and phorbol myristate acetate promoted an earlier and stronger expression of c-Jun, JunB, and of the phosphorylated forms of c-Fos.	Tetradecanoylphorbol Acetate	92-117	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	213-218
11093788-5	2000	TPA, a PKC activator, stimulated ICAM-1 expression as well, this effect being inhibited by tyrosine kinase inhibitors.	Tetradecanoylphorbol Acetate	0-3	intercellular adhesion molecule 1	Homo sapiens	33-39
11093788-9	2000	TPA also stimulated NF-kappaB DNA-protein binding and ICAM-1 promoter activity as well, these effects being inhibited by tyrosine kinase inhibitors.	Tetradecanoylphorbol Acetate	0-3	intercellular adhesion molecule 1	Homo sapiens	54-60
11093788-10	2000	Dominant-negative PKCalpha, NIK, or IKK2, but not IKK1 mutant, inhibited IL-1beta- or TPA-induced ICAM-1 promoter activity.	Tetradecanoylphorbol Acetate	86-89	intercellular adhesion molecule 1	Homo sapiens	98-104
11094104-4	2000	RESULTS: Pretreatment of T cells with IFN-beta potentiates the production of IL-10 when they interact with adult human microglia, human fetal microglia, or U937 cells treated with phorbol-12-myristate-13-acetate (PMA) and IFN-gamma.	Tetradecanoylphorbol Acetate	180-211	interleukin 10	Homo sapiens	77-82
11052995-7	2000	PYY secretion stimulated by phorbol 12-myristate 13-acetate and by forskolin was also more potently suppressed by S-28 and the octapeptide SSTR-5 analogs.	Tetradecanoylphorbol Acetate	28-59	peptide YY	Rattus norvegicus	0-3
10915787-4	2000	PMA treatment rapidly induced hVH5 transcripts in these cells, and induced expression of M3/6 completely inhibited PMA-stimulated phosphorylation of SAPK, suggesting a feedback loop to control SAPK activity.	Tetradecanoylphorbol Acetate	0-3	dual specificity phosphatase 8	Homo sapiens	30-34
11003570-2	2000	Depletion of the conventional (c) and novel (n) PKC isozymes following 24 h exposure of human pulmonary artery endothelial (HPAE) cells with the phorbol ester, phorbol 12-myristate 13-acetate (500 nM), failed to prevent TNF-alpha-induced oxidant generation.	Tetradecanoylphorbol Acetate	160-191	protein kinase C zeta	Homo sapiens	48-51
11129950-1	2000	The TIS11 gene is an immediate early gene that is induced rapidly and transiently by phorbol 12-myristate 13-acetate and various growth factors.	Tetradecanoylphorbol Acetate	85-116	zinc finger protein 36	Rattus norvegicus	4-9
10871606-2	2000	12-O-Tetradecanoylphorbol-13-acetate (TPA) induction of the FGF-BP gene occurs through transcriptional mechanisms involving Sp1, AP-1, and CCAATT/enhancer-binding protein sites in the proximal FGF-BP gene promoter.	Tetradecanoylphorbol Acetate	0-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	129-133
10871606-2	2000	12-O-Tetradecanoylphorbol-13-acetate (TPA) induction of the FGF-BP gene occurs through transcriptional mechanisms involving Sp1, AP-1, and CCAATT/enhancer-binding protein sites in the proximal FGF-BP gene promoter.	Tetradecanoylphorbol Acetate	38-41	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	129-133
11149424-0	2001	Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition.	Tetradecanoylphorbol Acetate	85-121	ornithine decarboxylase, structural 1	Mus musculus	130-153
11149424-0	2001	Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition.	Tetradecanoylphorbol Acetate	85-121	ornithine decarboxylase, structural 1	Mus musculus	155-158
11149424-0	2001	Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition.	Tetradecanoylphorbol Acetate	85-121	ornithine decarboxylase, structural 1	Mus musculus	231-234
10871606-9	2000	In vitro gel shift analysis revealed distinct and TPA-dependent binding of USF1 and USF2 to the repressor element that required nucleotides within the E-box.	Tetradecanoylphorbol Acetate	50-53	upstream transcription factor 2, c-fos interacting	Homo sapiens	84-88
3135941-7	1988	Cooperation between nuclear oncoproteins fos and jun is required for full activation of transcription from a TPA-responsive promoter element in transfected mammalian cells.	Tetradecanoylphorbol Acetate	109-112	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	41-44
10993214-4	2000	Although translocation of p47phox and p67phox to the membrane fraction by PMA-stimulation of intact and GCSF-treated neutrophils occurred in parallel with O2- production, that of CB-treated neutrophils by PMA-stimulation was not always proportional to O2- production.	Tetradecanoylphorbol Acetate	74-77	neutrophil cytosolic factor 1	Homo sapiens	26-33
10993217-3	2000	The dissociation constants (Kd"s) of TPA to PDI, histone H1 and PKCalpha were determined to be 1.03 x 10(-6) M, 5.70 x 10(-7) M, and 4.00 x 10(-7) m, respectively, by the surface plasmon resonance (SPR) method.	Tetradecanoylphorbol Acetate	37-40	H1.0 linker histone	Homo sapiens	49-59
3140790-0	1988	The inhibitory GTP-binding protein (Gi) occurs in rat Leydig cells and is differentially modified by lutropin and 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	114-150	RAS like proto-oncogene B	Rattus norvegicus	15-34
11012750-7	2000	Under stimulation conditions where increases in [Ca2+]i occur (e.g. PMA plus ionomycin or CD3 plus CD28 ligation) RANTES secretion can be severely reduced compared with the levels observed in response to the phorbol ester PMA.	Tetradecanoylphorbol Acetate	68-71	C-C motif chemokine ligand 5	Homo sapiens	114-120
3140790-0	1988	The inhibitory GTP-binding protein (Gi) occurs in rat Leydig cells and is differentially modified by lutropin and 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	114-150	RAS like proto-oncogene B	Rattus norvegicus	36-38
3140790-4	1988	The results implicate the presence of an inhibitory GTP-binding protein (Gi), which may be inhibited by TPA.	Tetradecanoylphorbol Acetate	104-107	RAS like proto-oncogene B	Rattus norvegicus	52-71
3140790-4	1988	The results implicate the presence of an inhibitory GTP-binding protein (Gi), which may be inhibited by TPA.	Tetradecanoylphorbol Acetate	104-107	RAS like proto-oncogene B	Rattus norvegicus	73-75
10851233-4	2000	The zinc-induced activation of p70S6k was partially inhibited by down-regulation of phorbol 12-myristate 13-acetate-responsive protein kinase C (PKC) by chronic treatment with phorbol 12-myristate 13-acetate, but this was not significant.	Tetradecanoylphorbol Acetate	84-115	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	31-37
3135944-0	1988	Antioxidants inhibit proliferation and cell surface expression of receptors for interleukin-2 and transferrin in T lymphocytes stimulated with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	143-168	transferrin	Mus musculus	98-109
10851233-4	2000	The zinc-induced activation of p70S6k was partially inhibited by down-regulation of phorbol 12-myristate 13-acetate-responsive protein kinase C (PKC) by chronic treatment with phorbol 12-myristate 13-acetate, but this was not significant.	Tetradecanoylphorbol Acetate	176-207	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	31-37
2837462-4	1988	In rat thymic lymphocytes, the increase in the level of c-fos RNA induced by the combination of 12-O-tetradecanoylphorbol 13-acetate and ionomycin was unaffected by inhibition of the antiport with 5-(N-ethyl-N-propyl)amiloride.	Tetradecanoylphorbol Acetate	96-132	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-61
10856305-4	2000	In platelets, cellular activation by thrombin or phorbol 12-myristate 13-acetate decreased the binding of syntaxin 4 with SNAP-23, another platelet t-SNARE.	Tetradecanoylphorbol Acetate	49-80	syntaxin 4	Homo sapiens	106-116
3260181-3	1988	Expression of the TSP-1 gene was observed in T lymphocytes in vitro in response to either phorbolester (phorbol 12-myristate 13-acetate), Ca2+ ionophore (A23187), lectin or alloantigen.	Tetradecanoylphorbol Acetate	104-135	serine protease 55	Homo sapiens	18-23
10856305-4	2000	In platelets, cellular activation by thrombin or phorbol 12-myristate 13-acetate decreased the binding of syntaxin 4 with SNAP-23, another platelet t-SNARE.	Tetradecanoylphorbol Acetate	49-80	synaptosome associated protein 23	Homo sapiens	122-129
10951141-5	2000	RESULTS: The IL-18 gene was constitutively transcribed by primary human keratinocytes and cell lines and was not significantly altered following exposure to IL-1 beta, tumour necrosis factor-alpha, interferon (IFN)-gamma, phorbol myristate acetate or nickel sulphate.	Tetradecanoylphorbol Acetate	222-247	interleukin 18	Homo sapiens	13-18
2845222-7	1988	The relevance of oxidant production to the tumor promotion process is suggested by the ability of exogenous xanthine/xanthine oxidase, a superoxide anion-generating system, to induce ornithine decarboxylase, a characteristic of TPA-treated cells.	Tetradecanoylphorbol Acetate	228-231	xanthine dehydrogenase	Mus musculus	117-133
10922477-1	2000	Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130.	Tetradecanoylphorbol Acetate	90-93	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	366-370
10908728-0	2000	Annexin-I inhibits PMA-induced c-fos SRE activation by suppressing cytosolic phospholipase A2 signal.	Tetradecanoylphorbol Acetate	19-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-36
2845222-7	1988	The relevance of oxidant production to the tumor promotion process is suggested by the ability of exogenous xanthine/xanthine oxidase, a superoxide anion-generating system, to induce ornithine decarboxylase, a characteristic of TPA-treated cells.	Tetradecanoylphorbol Acetate	228-231	ornithine decarboxylase, structural 1	Mus musculus	183-206
10908728-6	2000	The stimulation of Rat2 fibroblast cells with phorbol 12-myristate 13-acetate (PMA) induced the c-fos serum response element (SRE).	Tetradecanoylphorbol Acetate	46-77	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	96-101
2456821-4	1988	In the absence of VIP, the calcium ionophore, ionomycin, and the phorbol ester, phorbol 12-myristate-13-acetate, also stimulate somatostatin release.	Tetradecanoylphorbol Acetate	80-111	somatostatin	Homo sapiens	128-140
10908728-6	2000	The stimulation of Rat2 fibroblast cells with phorbol 12-myristate 13-acetate (PMA) induced the c-fos serum response element (SRE).	Tetradecanoylphorbol Acetate	79-82	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	96-101
10866321-5	2000	In a transient transfection assay, all three RAR subtypes, RARalpha, RARbeta, and RARgamma, could effectively inhibit phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity and the activity of oncogenes c-Jun and c-Fos on AP-1 containing reporter genes in the presence of retinoic acid (RA).	Tetradecanoylphorbol Acetate	132-168	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	177-181
10866321-5	2000	In a transient transfection assay, all three RAR subtypes, RARalpha, RARbeta, and RARgamma, could effectively inhibit phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity and the activity of oncogenes c-Jun and c-Fos on AP-1 containing reporter genes in the presence of retinoic acid (RA).	Tetradecanoylphorbol Acetate	132-168	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	221-226
10866321-5	2000	In a transient transfection assay, all three RAR subtypes, RARalpha, RARbeta, and RARgamma, could effectively inhibit phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity and the activity of oncogenes c-Jun and c-Fos on AP-1 containing reporter genes in the presence of retinoic acid (RA).	Tetradecanoylphorbol Acetate	132-168	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	231-236
10866321-5	2000	In a transient transfection assay, all three RAR subtypes, RARalpha, RARbeta, and RARgamma, could effectively inhibit phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity and the activity of oncogenes c-Jun and c-Fos on AP-1 containing reporter genes in the presence of retinoic acid (RA).	Tetradecanoylphorbol Acetate	132-168	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	240-244
3135916-6	1988	These results, demonstrating a specific effect of TPA in enhancing the hypoglycemic response to central TRH or its neuroactive, though not inactive, analogs are consistent with a possible role for PKC in the mechanism of TRH action in the CNS.	Tetradecanoylphorbol Acetate	50-53	thyrotropin releasing hormone	Mus musculus	104-107
10848707-9	2000	The expression of c-Fos was increased by phorbol 12-myristate 13-acetate added before NGF, suggesting that c-Fos may be involved in regulating NGF production.	Tetradecanoylphorbol Acetate	41-72	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-23
10848707-9	2000	The expression of c-Fos was increased by phorbol 12-myristate 13-acetate added before NGF, suggesting that c-Fos may be involved in regulating NGF production.	Tetradecanoylphorbol Acetate	41-72	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-112
3135916-6	1988	These results, demonstrating a specific effect of TPA in enhancing the hypoglycemic response to central TRH or its neuroactive, though not inactive, analogs are consistent with a possible role for PKC in the mechanism of TRH action in the CNS.	Tetradecanoylphorbol Acetate	50-53	thyrotropin releasing hormone	Mus musculus	221-224
3349487-0	1988	Inhibition of tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced synthesis of epidermal ornithine decarboxylase messenger RNA and diacylglycerol-promoted mouse skin tumor formation by retinoic acid.	Tetradecanoylphorbol Acetate	29-65	ornithine decarboxylase, structural 1	Mus musculus	97-120
3349487-1	1988	Evidence is presented that inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC; EC 4.1.1.17) by retinoic acid may involve inhibition of protein kinase C-mediated synthesis of ODC mRNA.	Tetradecanoylphorbol Acetate	41-77	ornithine decarboxylase, structural 1	Mus musculus	92-115
10959625-2	2000	Previous study using promotion-sensitive JB6 mouse epidermal cells, an in vitro model of the promotion stage of multistage carcinogenesis, showed that the expression of cyclin D1 is stimulated in the presence (but not in the absence) of 12-O-tetradecanoylphorbol-13-acetate (TPA) in these cells maintained under anchorage-independent culture conditions.	Tetradecanoylphorbol Acetate	237-273	cyclin D1	Mus musculus	169-178
10959625-2	2000	Previous study using promotion-sensitive JB6 mouse epidermal cells, an in vitro model of the promotion stage of multistage carcinogenesis, showed that the expression of cyclin D1 is stimulated in the presence (but not in the absence) of 12-O-tetradecanoylphorbol-13-acetate (TPA) in these cells maintained under anchorage-independent culture conditions.	Tetradecanoylphorbol Acetate	275-278	cyclin D1	Mus musculus	169-178
10959625-8	2000	Since TPA is capable of stimulating the expression of cyclin D1 not only through TRE but also through CRE and NF-kappaB response element in the promoter, we tentatively propose a sequence of events that possibly leads to TPA-induced, anchorage-independent synthesis of cyclins D1 and A in the promotion-sensitive JB6 mouse epidermal cells.	Tetradecanoylphorbol Acetate	6-9	cyclin D1	Mus musculus	54-63
3349487-1	1988	Evidence is presented that inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC; EC 4.1.1.17) by retinoic acid may involve inhibition of protein kinase C-mediated synthesis of ODC mRNA.	Tetradecanoylphorbol Acetate	41-77	ornithine decarboxylase, structural 1	Mus musculus	117-120
3349487-1	1988	Evidence is presented that inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC; EC 4.1.1.17) by retinoic acid may involve inhibition of protein kinase C-mediated synthesis of ODC mRNA.	Tetradecanoylphorbol Acetate	41-77	ornithine decarboxylase, structural 1	Mus musculus	217-220
10848898-8	2000	Contemporaneous stimulation of eosinophils with PMA and Mn2+ induced a dramatically increased release of ECP regardless of which protein the eosinophils were adhering to.	Tetradecanoylphorbol Acetate	48-51	ribonuclease A family member 3	Homo sapiens	105-108
3349487-1	1988	Evidence is presented that inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC; EC 4.1.1.17) by retinoic acid may involve inhibition of protein kinase C-mediated synthesis of ODC mRNA.	Tetradecanoylphorbol Acetate	79-82	ornithine decarboxylase, structural 1	Mus musculus	92-115
3349487-1	1988	Evidence is presented that inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC; EC 4.1.1.17) by retinoic acid may involve inhibition of protein kinase C-mediated synthesis of ODC mRNA.	Tetradecanoylphorbol Acetate	79-82	ornithine decarboxylase, structural 1	Mus musculus	117-120
3349487-1	1988	Evidence is presented that inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC; EC 4.1.1.17) by retinoic acid may involve inhibition of protein kinase C-mediated synthesis of ODC mRNA.	Tetradecanoylphorbol Acetate	79-82	ornithine decarboxylase, structural 1	Mus musculus	217-220
10779366-0	2000	Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C. Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate induced a continuous decrease in the gamma-aminobutyric acid (GABA)-activated current amplitude from recombinant GABA receptors (formed by rho1 or alphabetagamma subunits) expressed in Xenopus oocytes.	Tetradecanoylphorbol Acetate	143-174	GABA(A) receptor-associated protein L homeolog	Xenopus laevis	26-59
3349487-2	1988	A single application of 10 nmol of TPA to intact mouse skin led to an increase in the steady state levels of epidermal ODC mRNA; a maximal level of ODC mRNA occurred at about 3.5 h after TPA treatment.	Tetradecanoylphorbol Acetate	35-38	ornithine decarboxylase, structural 1	Mus musculus	119-122
3349487-2	1988	A single application of 10 nmol of TPA to intact mouse skin led to an increase in the steady state levels of epidermal ODC mRNA; a maximal level of ODC mRNA occurred at about 3.5 h after TPA treatment.	Tetradecanoylphorbol Acetate	35-38	ornithine decarboxylase, structural 1	Mus musculus	148-151
3349487-3	1988	TPA-induced increase in ODC mRNA preceded the increase in epidermal ODC activity.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	24-27
3349487-3	1988	TPA-induced increase in ODC mRNA preceded the increase in epidermal ODC activity.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	68-71
10777594-6	2000	Moreover, phorbol myristate acetate, a potent anti-apoptotic effector, was found to protect SRF completely from cleavage by caspase 3 and also to prevent the inhibition of the c-FOS promoter activity by death effectors.	Tetradecanoylphorbol Acetate	10-35	serum response factor	Homo sapiens	92-95
10777594-6	2000	Moreover, phorbol myristate acetate, a potent anti-apoptotic effector, was found to protect SRF completely from cleavage by caspase 3 and also to prevent the inhibition of the c-FOS promoter activity by death effectors.	Tetradecanoylphorbol Acetate	10-35	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	176-181
3349487-4	1988	Application of 17 nmol of retinoic acid 1 h before application of TPA to mouse skin inhibited the induction of both ODC mRNA and ODC activity.	Tetradecanoylphorbol Acetate	66-69	ornithine decarboxylase, structural 1	Mus musculus	116-119
3349487-4	1988	Application of 17 nmol of retinoic acid 1 h before application of TPA to mouse skin inhibited the induction of both ODC mRNA and ODC activity.	Tetradecanoylphorbol Acetate	66-69	ornithine decarboxylase, structural 1	Mus musculus	129-132
3349487-5	1988	Using the DNA-excess filter hybridization technique, we found that TPA-increased steady state levels of ODC mRNA in primary culture of newborn mouse epidermal cells were the result of enhanced accumulation of newly synthesized ODC mRNA.	Tetradecanoylphorbol Acetate	67-70	ornithine decarboxylase, structural 1	Mus musculus	104-107
3349487-5	1988	Using the DNA-excess filter hybridization technique, we found that TPA-increased steady state levels of ODC mRNA in primary culture of newborn mouse epidermal cells were the result of enhanced accumulation of newly synthesized ODC mRNA.	Tetradecanoylphorbol Acetate	67-70	ornithine decarboxylase, structural 1	Mus musculus	227-230
10760470-5	2000	In addition, we found that the hLysoPLA I can be up-regulated by phorbol 12-myristate 13-acetate (PMA) stimulation, a process in which phospholipase A(2) is activated and lysophospholipids are generated in WISH cells.	Tetradecanoylphorbol Acetate	65-96	lysophospholipase 1	Homo sapiens	31-41
10760470-5	2000	In addition, we found that the hLysoPLA I can be up-regulated by phorbol 12-myristate 13-acetate (PMA) stimulation, a process in which phospholipase A(2) is activated and lysophospholipids are generated in WISH cells.	Tetradecanoylphorbol Acetate	98-101	lysophospholipase 1	Homo sapiens	31-41
10760470-6	2000	Furthermore, the PMA-induced hLysoPLA I expression can be blocked by the protein kinase C (PKC) inhibitor Go6976.	Tetradecanoylphorbol Acetate	17-20	lysophospholipase 1	Homo sapiens	29-39
11208899-2	2001	Ro31-8220, a PKC inhibitor, reduced TPA-stimulated release of choline- and ethanolamine-metabolites to basal levels.	Tetradecanoylphorbol Acetate	36-39	protein kinase C, alpha	Rattus norvegicus	13-16
11208899-7	2001	Exposure of bipolar undifferentiated CG-4 line cells to TPA resulted in down-regulatation of PKC-alpha and PKC-beta which could not be detected by Western blotting after a few hours; PKC-epsilon was down-regulated much more slowly but PKCs delta, zeta and iota were not influenced by 48 h exposure of cells to TPA.	Tetradecanoylphorbol Acetate	56-59	protein kinase C, alpha	Rattus norvegicus	93-102
11208899-7	2001	Exposure of bipolar undifferentiated CG-4 line cells to TPA resulted in down-regulatation of PKC-alpha and PKC-beta which could not be detected by Western blotting after a few hours; PKC-epsilon was down-regulated much more slowly but PKCs delta, zeta and iota were not influenced by 48 h exposure of cells to TPA.	Tetradecanoylphorbol Acetate	56-59	protein kinase C, beta	Rattus norvegicus	107-115
3349487-7	1988	Exposure of primary cultures of newborn epidermal cells to retinoic acid, in conjunction with TPA, inhibited the synthesis of ODC mRNA and failed to alter the half-life of ODC mRNA.	Tetradecanoylphorbol Acetate	94-97	ornithine decarboxylase, structural 1	Mus musculus	126-129
3349487-8	1988	These results implicate the role of transcription activation in TPA-induced ODC gene expression and indicate that retinoic acid may inhibit TPA-induced ODC gene transcription.	Tetradecanoylphorbol Acetate	64-67	ornithine decarboxylase, structural 1	Mus musculus	76-79
11087222-5	2000	Western blot analysis demonstrated an increased PKC-epsilon translocation after exposure to R-PIA, Phe, and the PKC activators dioctanoylglycerol (50 microM) and phorbol myristate acetate (1 microM).	Tetradecanoylphorbol Acetate	162-187	protein kinase C, gamma	Rattus norvegicus	48-51
3349487-8	1988	These results implicate the role of transcription activation in TPA-induced ODC gene expression and indicate that retinoic acid may inhibit TPA-induced ODC gene transcription.	Tetradecanoylphorbol Acetate	140-143	ornithine decarboxylase, structural 1	Mus musculus	152-155
3349487-11	1988	Taken together, one may conclude that the mechanism of inhibition of TPA-induced ODC by retinoic acid may involve the inhibition of protein kinase C-mediated accumulation of newly synthesized ODC mRNA.	Tetradecanoylphorbol Acetate	69-72	ornithine decarboxylase, structural 1	Mus musculus	81-84
10792504-8	2000	These results suggest that PMA induces the transcriptional activation of the MCP-3 gene through de novo protein synthesis and the rapid decay of PMA-induced MCP-3 mRNA through de novo synthesis of adenosine/uridine (AU)-rich element binding proteins and cAMP signalling inhibits the PMA-induced transcriptional activation of the MCP-3 gene expression.	Tetradecanoylphorbol Acetate	27-30	C-C motif chemokine ligand 7	Homo sapiens	157-162
3349487-11	1988	Taken together, one may conclude that the mechanism of inhibition of TPA-induced ODC by retinoic acid may involve the inhibition of protein kinase C-mediated accumulation of newly synthesized ODC mRNA.	Tetradecanoylphorbol Acetate	69-72	ornithine decarboxylase, structural 1	Mus musculus	192-195
10792504-8	2000	These results suggest that PMA induces the transcriptional activation of the MCP-3 gene through de novo protein synthesis and the rapid decay of PMA-induced MCP-3 mRNA through de novo synthesis of adenosine/uridine (AU)-rich element binding proteins and cAMP signalling inhibits the PMA-induced transcriptional activation of the MCP-3 gene expression.	Tetradecanoylphorbol Acetate	27-30	C-C motif chemokine ligand 7	Homo sapiens	157-162
11200811-3	2000	METHOD OF STUDY: Phytohemaglutinin (PHA) or phorbol myristate acetate (PMA) activated T cell adhesion to the following extracellular matrix proteins: collagen IV, fibronectin and elastin were studied in women with the history of RSA.	Tetradecanoylphorbol Acetate	44-69	elastin	Homo sapiens	179-186
3258598-7	1988	Platelet-derived growth factor, fibroblast growth factor, insulin-like growth factor-I, insulin, phorbol esters (12-O-tetradecanoylphorbol 13-acetate and phorbol 12,13-dibutyrate), and fresh fetal calf serum also induced activation of the MAP2 kinase in the quiescent TIG-3 cells.	Tetradecanoylphorbol Acetate	113-149	microtubule associated protein 2	Homo sapiens	239-243
11200811-3	2000	METHOD OF STUDY: Phytohemaglutinin (PHA) or phorbol myristate acetate (PMA) activated T cell adhesion to the following extracellular matrix proteins: collagen IV, fibronectin and elastin were studied in women with the history of RSA.	Tetradecanoylphorbol Acetate	71-74	elastin	Homo sapiens	179-186
11125308-4	2000	However, following stimulation with lipopolysaccharide or phorbol myristate acetate/calcium ionophore, peritoneal cells from H2(b) mice synthesised significantly more IL-1 beta, TNF-alpha, TNFR and IFN-gamma protein and IFN-gamma mRNA than cells from congenic H2(k) or H2(d) mice.	Tetradecanoylphorbol Acetate	58-83	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	189-193
11082462-7	2000	Intracolonic administration of the phorbol ester phorbol-12-myristate-13-acetate (PMA; 3 mg kg(-1)) increased colonic cellular PKC activity within 2 h after instillation.	Tetradecanoylphorbol Acetate	49-80	protein kinase C, gamma	Rattus norvegicus	127-130
10694257-5	2000	G-proteins were activated by including 0.4 mM GTP or 0.1 mM GTP-gamma-S in the pipette, and PKC was activated by bath application of 500 nM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	140-171	protein kinase C, gamma	Rattus norvegicus	92-95
10694257-5	2000	G-proteins were activated by including 0.4 mM GTP or 0.1 mM GTP-gamma-S in the pipette, and PKC was activated by bath application of 500 nM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	173-176	protein kinase C, gamma	Rattus norvegicus	92-95
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Tetradecanoylphorbol Acetate	152-155	integrin subunit alpha M	Homo sapiens	257-262
11082462-7	2000	Intracolonic administration of the phorbol ester phorbol-12-myristate-13-acetate (PMA; 3 mg kg(-1)) increased colonic cellular PKC activity within 2 h after instillation.	Tetradecanoylphorbol Acetate	82-85	protein kinase C, gamma	Rattus norvegicus	127-130
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Tetradecanoylphorbol Acetate	152-155	integrin subunit alpha M	Homo sapiens	264-269
3258598-8	1988	The activated MAP2 kinase activity in cells stimulated by platelet-derived growth factor, fibroblast growth factor, insulin-like growth factor-I, insulin, 12-O-tetradecanoylphorbol 13-acetate, phorbol 12,13-dibutyrate, or fetal calf serum was almost completely inhibited by 2 microM Ca2+, like the EGF-stimulated kinase.	Tetradecanoylphorbol Acetate	155-191	microtubule associated protein 2	Homo sapiens	14-18
2833174-12	1988	Interestingly in the TPA-treated platelet membrane, thrombin stimulated GTPase activity to a higher level than that in untreated platelet membrane.	Tetradecanoylphorbol Acetate	21-24	prothrombin	Oryctolagus cuniculus	52-60
10735602-7	2000	However, by in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, peripheral CD4 cells demonstrated a significant decrease of IFN-gamma-producing T helper 1 (Th1) cells and an increase of IL-4-producing T helper 2 (Th2) cells after immunotherapy.	Tetradecanoylphorbol Acetate	37-68	negative elongation factor complex member C/D	Homo sapiens	182-185
10735602-7	2000	However, by in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, peripheral CD4 cells demonstrated a significant decrease of IFN-gamma-producing T helper 1 (Th1) cells and an increase of IL-4-producing T helper 2 (Th2) cells after immunotherapy.	Tetradecanoylphorbol Acetate	70-73	negative elongation factor complex member C/D	Homo sapiens	182-185
10670466-7	2000	PMA completely inhibited the cholinergic agonist-induced plateau of [Ca2+]i. PMA and calyculin A decreased both the [Ca2+]i transient and the plateau of [Ca2+]i induced by thapsigargin, further supporting the idea that PKC modulates the entry of Ca2+.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, gamma	Rattus norvegicus	219-222
11205273-6	2000	TPA, which up-regulates the expression of beta 1 integrins, increases invasiveness of cells.	Tetradecanoylphorbol Acetate	0-3	integrin subunit beta 1	Homo sapiens	42-58
11073105-7	2000	The present PMA-stimulated system was inhibited by the anti-FcgammaRII mAb IV.3, the anti-CD18 mAb MEM 48, and the anti-CD11b mAb 2LPM19c but not by the anti-CD66b mAb 80H3 and N-acetyl-D-glucosamine.	Tetradecanoylphorbol Acetate	12-15	integrin subunit alpha M	Homo sapiens	120-125
10934195-7	2000	Forskolin and phorbol myristate acetate acted synergistically to enhance transcription of an AP1(-73COL)-luciferase construct.	Tetradecanoylphorbol Acetate	14-39	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-96
3129437-1	1988	In Chinese hamster ovary (CHO) fibroblast cells the protein kinase C activating phorbol ester, phorbol myristate acetate (PMA), stimulates an increase in cell surface transferrin receptor (TR) expression by increasing the exocytic rate of the recycling pathway.	Tetradecanoylphorbol Acetate	95-120	transferrin receptor protein 1	Cricetulus griseus	167-187
10915802-5	2000	In contrast to the CNP-dependent desensitization process, which results in coordinate dephosphorylation of all five sites in the receptor, phorbol 12-myristate 13-acetate treatment causes the dephosphorylation of only one site, which we have identified as Ser(523).	Tetradecanoylphorbol Acetate	139-170	natriuretic peptide C	Homo sapiens	19-22
3129437-1	1988	In Chinese hamster ovary (CHO) fibroblast cells the protein kinase C activating phorbol ester, phorbol myristate acetate (PMA), stimulates an increase in cell surface transferrin receptor (TR) expression by increasing the exocytic rate of the recycling pathway.	Tetradecanoylphorbol Acetate	95-120	transferrin receptor protein 1	Cricetulus griseus	189-191
3129437-1	1988	In Chinese hamster ovary (CHO) fibroblast cells the protein kinase C activating phorbol ester, phorbol myristate acetate (PMA), stimulates an increase in cell surface transferrin receptor (TR) expression by increasing the exocytic rate of the recycling pathway.	Tetradecanoylphorbol Acetate	122-125	transferrin receptor protein 1	Cricetulus griseus	167-187
11066030-8	2000	With respect to the ADR, the PMA protective effect was lost in the presence of the selective PKC inhibitor myristoylated epidermal growth factor peptide 651d-658 (Myr-PKCI; 10 microM).	Tetradecanoylphorbol Acetate	29-32	protein kinase C iota	Homo sapiens	167-171
10644756-7	2000	The inhibitory effect of PDGF on GH-induced tyrosyl phosphorylation of JAK2 and GHR is abolished by depletion of 4beta-phorbol 12-myristate 13-acetate (PMA)-sensitive PKCs with chronic PMA treatment and is severely inhibited by GF109203X, an inhibitor of PKCs.	Tetradecanoylphorbol Acetate	113-150	growth hormone receptor	Homo sapiens	80-83
10644756-7	2000	The inhibitory effect of PDGF on GH-induced tyrosyl phosphorylation of JAK2 and GHR is abolished by depletion of 4beta-phorbol 12-myristate 13-acetate (PMA)-sensitive PKCs with chronic PMA treatment and is severely inhibited by GF109203X, an inhibitor of PKCs.	Tetradecanoylphorbol Acetate	152-155	growth hormone receptor	Homo sapiens	80-83
3129437-1	1988	In Chinese hamster ovary (CHO) fibroblast cells the protein kinase C activating phorbol ester, phorbol myristate acetate (PMA), stimulates an increase in cell surface transferrin receptor (TR) expression by increasing the exocytic rate of the recycling pathway.	Tetradecanoylphorbol Acetate	122-125	transferrin receptor protein 1	Cricetulus griseus	189-191
10644756-7	2000	The inhibitory effect of PDGF on GH-induced tyrosyl phosphorylation of JAK2 and GHR is abolished by depletion of 4beta-phorbol 12-myristate 13-acetate (PMA)-sensitive PKCs with chronic PMA treatment and is severely inhibited by GF109203X, an inhibitor of PKCs.	Tetradecanoylphorbol Acetate	185-188	growth hormone receptor	Homo sapiens	80-83
2832424-9	1988	The induction of ODC mRNA by either LPS or TPA was blocked by the addition of cycloheximide (25 micrograms/ml) or anisomycin (0.1 mM) to the cellular incubation mixture.	Tetradecanoylphorbol Acetate	43-46	ornithine decarboxylase, structural 1	Mus musculus	17-20
12749772-2	2000	The down-modulation induced upon cellular activation with PMA is due to proteolytic shedding mediated by a cysteine metalloprotease, presumably the TNF-alpha converting enzyme (TALE), and is susceptible to inhibitors of the hydroxamate class.	Tetradecanoylphorbol Acetate	58-61	ADAM metallopeptidase domain 17	Homo sapiens	148-175
10893237-2	2000	Activation of endogenous PKC by phorbol 12-myristate 13-acetate inhibited both Galpha(q)-coupled (oxytocin and M1 muscarinic) and Galpha(i)-coupled (formyl-Met-Leu-Phe) receptor-stimulated PI turnover by 50-100% in PHM1, HeLa, COSM6, and RBL-2H3 cells expressing PLCbeta(3).	Tetradecanoylphorbol Acetate	32-63	phospholipase C beta 3	Rattus norvegicus	263-273
10972960-5	2000	Pharmacological studies using the PKC activator, phorbol myristate acetate, and inhibitors, calphostin-C, and staurosporine, demonstrated PKC activity to be inversely related to NCAM polysialylation in the mouse neuro-2A cell line.	Tetradecanoylphorbol Acetate	49-74	protein kinase C, delta	Mus musculus	138-141
12749772-2	2000	The down-modulation induced upon cellular activation with PMA is due to proteolytic shedding mediated by a cysteine metalloprotease, presumably the TNF-alpha converting enzyme (TALE), and is susceptible to inhibitors of the hydroxamate class.	Tetradecanoylphorbol Acetate	58-61	ADAM metallopeptidase domain 17	Homo sapiens	177-181
2832424-10	1988	This indicated that protein synthesis was required as a prerequisite to LPS or TPA induction of ODC mRNA.	Tetradecanoylphorbol Acetate	79-82	ornithine decarboxylase, structural 1	Mus musculus	96-99
10572244-10	1999	PD98059, an inhibitor of the upstream kinase that activates p42/p44 MAP kinase, suppressed the induction of HSP27 stimulated by PGF(2alpha) or TPA.	Tetradecanoylphorbol Acetate	143-146	heat shock protein 1	Mus musculus	108-113
2832424-12	1988	Stimulation with 8-bromo-cAMP in addition to LPS has been shown to enhance the induction of ODC over that induced by LPS or TPA alone.	Tetradecanoylphorbol Acetate	124-127	ornithine decarboxylase, structural 1	Mus musculus	92-95
3278004-3	1988	We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18).	Tetradecanoylphorbol Acetate	14-39	integrin subunit alpha M	Homo sapiens	152-157
10615860-0	1999	Evaluation of the potential of cancer chemopreventive activity mediated by inhibition of 12-O-tetradecanoyl phorbol 13-acetate-induced ornithine decarboxylase activity.	Tetradecanoylphorbol Acetate	89-126	ornithine decarboxylase, structural 1	Mus musculus	135-158
10615860-1	1999	In order to discover new cancer chemopreventive agents from natural or synthetic products, a structurally diverse class of chemopreventive agents was evaluated using in vitro biomarker of inhibition of 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in cultured mouse epidermal 308 (ME 308) cells.	Tetradecanoylphorbol Acetate	202-238	ornithine decarboxylase, structural 1	Mus musculus	253-276
10996858-4	2000	Furthermore, the ability to translocate was present in young animals after a short treatment with the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA; 100 nM) or dioctanoyl-glycerol (50 microM), whereas the ability was absent in aged rats, suggesting that PKC function was impaired with aging independent of agonist stimulation.	Tetradecanoylphorbol Acetate	155-158	protein kinase C, alpha	Rattus norvegicus	265-268
10971511-3	2000	The influence of TA on the expression of ICAM-1 and MHC-I was studied on resting and phorbol myristate acetate (PMA)- or interferon-gamma (IFN-gamma)- and/or tumour necrosis factor-alpha (TNF-alpha)-activated cells using flow cytometry and immunocytochemistry.	Tetradecanoylphorbol Acetate	85-110	intercellular adhesion molecule 1	Homo sapiens	41-47
11012750-1	2000	This study has examined the stimuli required for secretion of regulated upon activation, normal T-cell expressed, presumed secreted (RANTES) from T lymphocytes and found that stimuli such as phorbol 12-myristate 13-acetate (PMA), which are unable to support T-cell proliferation and interleukin-2 (IL-2) production, are nevertheless able to elicit strong secretion of RANTES.	Tetradecanoylphorbol Acetate	224-227	C-C motif chemokine ligand 5	Homo sapiens	133-139
11012750-5	2000	Our data also indicate that the observed effects of PMA on RANTES secretion are probably due to activation of protein kinase C (PKC) isoenzymes, since RANTES secretion was unaffected by the non-PKC activating 4alpha-phorbol ester, whilst the general PKC inhibitor Ro-32-0432 inhibits PMA-stimulated RANTES secretion.	Tetradecanoylphorbol Acetate	52-55	C-C motif chemokine ligand 5	Homo sapiens	59-65
10590230-6	1999	ASF/SF2 mRNA levels were decreased 2-fold in both MNNG-initiated cells and TPA-induced transformed cells compared with the normal parental cells, whereas hnRNP A2 mRNA expression did not significantly change between these three types of cells.	Tetradecanoylphorbol Acetate	75-78	serine and arginine-rich splicing factor 1	Mus musculus	0-7
10590230-8	1999	Moreover, RT-PCR analysis showed that distinct forms of ASF/SF2 mRNA were present in the MNNG-initiated cells and TPA-induced transformed cells but not in the parental cells.	Tetradecanoylphorbol Acetate	114-117	serine and arginine-rich splicing factor 1	Mus musculus	56-63
3278004-3	1988	We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18).	Tetradecanoylphorbol Acetate	14-39	integrin subunit alpha M	Homo sapiens	225-230
10969179-9	2000	In THP-1 myeloid leukemia cells pretreated with TPA (to induce receptors for IFN-gamma), IFN-gamma induced SOCS-2.	Tetradecanoylphorbol Acetate	48-51	suppressor of cytokine signaling 2	Homo sapiens	107-113
3278004-3	1988	We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18).	Tetradecanoylphorbol Acetate	41-44	integrin subunit alpha M	Homo sapiens	152-157
3278004-3	1988	We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18).	Tetradecanoylphorbol Acetate	41-44	integrin subunit alpha M	Homo sapiens	225-230
3278004-5	1988	Pretreatment of neutrophils with the anion channel-blocking agent, DIDS (4,4"-diisothiocyanostilbene-2,2"-disulfonic acid), inhibited the increased surface expression of CD11b and CD18 after stimulation by PMA, A23187, or FMLP and resulted in nearly complete inhibition of neutrophil aggregation.	Tetradecanoylphorbol Acetate	206-209	integrin subunit alpha M	Homo sapiens	170-175
3276673-2	1988	Both insulin and the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) induced c-fos mRNA accumulation in cells expressing high numbers of normal human insulin receptors; PMA but not insulin was effective in the cells expressing the mutant receptor.	Tetradecanoylphorbol Acetate	51-82	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	97-102
10806207-6	2000	Treatment of HeLa cells with tumor necrosis factor, epidermal growth factor, phorbol 12-myristate 13-acetate, and ionomycin but not with insulin resulted in strong activation of endogenous RSKB.	Tetradecanoylphorbol Acetate	77-108	ribosomal protein S6 kinase A4	Homo sapiens	189-193
10659998-5	1999	Prior treatment of VSMCs with staurosporine (1 microM), a PKC inhibitor, inhibited the ability of PMA to attenuate BK-induced responses, suggesting that the inhibitory effect of PMA is mediated through the activation of PKC.	Tetradecanoylphorbol Acetate	98-101	protein kinase C, alpha	Rattus norvegicus	58-61
10659998-5	1999	Prior treatment of VSMCs with staurosporine (1 microM), a PKC inhibitor, inhibited the ability of PMA to attenuate BK-induced responses, suggesting that the inhibitory effect of PMA is mediated through the activation of PKC.	Tetradecanoylphorbol Acetate	98-101	protein kinase C, alpha	Rattus norvegicus	220-223
3276673-2	1988	Both insulin and the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) induced c-fos mRNA accumulation in cells expressing high numbers of normal human insulin receptors; PMA but not insulin was effective in the cells expressing the mutant receptor.	Tetradecanoylphorbol Acetate	84-87	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	97-102
10567579-5	1999	Activation of PKCdelta by 12-O-tetradecanoylphorbol-13-acetate (TPA) at a nanomolar concentration was lethal to normal and neoplastic mouse and human keratinocytes overexpressing PKCdelta.	Tetradecanoylphorbol Acetate	26-62	protein kinase C, delta	Mus musculus	14-22
10567579-5	1999	Activation of PKCdelta by 12-O-tetradecanoylphorbol-13-acetate (TPA) at a nanomolar concentration was lethal to normal and neoplastic mouse and human keratinocytes overexpressing PKCdelta.	Tetradecanoylphorbol Acetate	64-67	protein kinase C, delta	Mus musculus	14-22
10913371-4	2000	In addition, the transactivational activity of TIS11 was found to be significantly reduced by treating the transfectants with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	126-157	zinc finger protein 36	Rattus norvegicus	47-52
2827679-3	1988	Moreover, protein kinase C-activating 12-O-tetradecanoylphorbol-13-acetate and Ca2+-ionophore A23187 increased the c-fos mRNA level in an additive manner.	Tetradecanoylphorbol Acetate	38-74	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	115-120
10913371-4	2000	In addition, the transactivational activity of TIS11 was found to be significantly reduced by treating the transfectants with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	159-162	zinc finger protein 36	Rattus norvegicus	47-52
10913371-5	2000	PMA-induced inactivation of TIS11 was blocked by calphostin C, a protein kinase C inhibitor, and PD98059, a mitogen-activated protein (MAP) kinase kinase inhibitor.	Tetradecanoylphorbol Acetate	0-3	zinc finger protein 36	Rattus norvegicus	28-33
10569809-7	1999	Pretreatment of mice with silymarin also produced highly significant inhibition of TPA-caused induction of epidermal lipid peroxidation (47-66% inhibition, P &lt; 0.001) and myeloperoxidase activity (56-100% inhibition, P &lt; 0.001).	Tetradecanoylphorbol Acetate	83-86	myeloperoxidase	Mus musculus	174-189
10551813-6	1999	However, down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PKC inhibitor Ro-31-8220 did not block the activation of p70(S6k) by ROS, indicating that the activation of TPA-responsive PKC was not required for stimulation of p70(S6k) activity by H(2)O(2) in JB6 cells.	Tetradecanoylphorbol Acetate	134-137	annexin A6	Homo sapiens	209-212
10551813-6	1999	However, down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PKC inhibitor Ro-31-8220 did not block the activation of p70(S6k) by ROS, indicating that the activation of TPA-responsive PKC was not required for stimulation of p70(S6k) activity by H(2)O(2) in JB6 cells.	Tetradecanoylphorbol Acetate	134-137	annexin A6	Homo sapiens	315-318
10949928-1	2000	The transcription factor Bach2, a member of the BTB-basic region leucine zipper (bZip) factor family, binds to a 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive element and the related Maf-recognition element (MARE) by forming homodimers or heterodimers with Maf-related transcription factors.	Tetradecanoylphorbol Acetate	113-149	BTB domain and CNC homolog 2	Homo sapiens	25-30
10949928-1	2000	The transcription factor Bach2, a member of the BTB-basic region leucine zipper (bZip) factor family, binds to a 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive element and the related Maf-recognition element (MARE) by forming homodimers or heterodimers with Maf-related transcription factors.	Tetradecanoylphorbol Acetate	151-154	BTB domain and CNC homolog 2	Homo sapiens	25-30
3128036-3	1988	After exposure to TPA, HL-60, Epstein-Barr virus-immortalized B-cell lines, Molt-3, MT-2 and B-CLLs showed markedly augmented CD9 expression.	Tetradecanoylphorbol Acetate	18-21	CD9 molecule	Homo sapiens	126-129
10968651-4	2000	RESULTS: In control rat myocytes, pretreatment with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), reduced the rate of Mn2+ quench to 68% of the untreated cell response.	Tetradecanoylphorbol Acetate	52-83	protein kinase C, alpha	Rattus norvegicus	125-128
10968651-4	2000	RESULTS: In control rat myocytes, pretreatment with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), reduced the rate of Mn2+ quench to 68% of the untreated cell response.	Tetradecanoylphorbol Acetate	85-88	protein kinase C, alpha	Rattus norvegicus	125-128
3128036-6	1988	Although CD9 is known to be one of the most useful markers of pre-B-cell common acute lymphoblastic leukemia, the expression of CD9 does not seem to be restricted to any specific cell lineage and can be induced in various hematopoietic cell lineages by treatment with TPA.	Tetradecanoylphorbol Acetate	268-271	CD9 molecule	Homo sapiens	128-131
2827513-0	1988	Effect of phorbol myristate acetate on secretion of parathyroid hormone.	Tetradecanoylphorbol Acetate	10-35	parathyroid hormone	Bos taurus	52-71
10913062-4	2000	The c-fos gene expression was also enhanced by 13-O-tetradecanoyl phorbol-13-acetate (TPA) in early passage but was somewhat suppressed in the late passage.	Tetradecanoylphorbol Acetate	86-89	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-9
10947075-3	2000	In contrast, the chronic treatment with PMA increased the expression of PKCepsilon and PKCzeta.	Tetradecanoylphorbol Acetate	40-43	protein kinase C zeta	Homo sapiens	87-94
10578141-9	1999	4 The extent of cellular damage in response to addition of SNAP to the incubation medium was enhanced by coincubation with the PKC activator, phorbol 12-myristate 13-acetate (PMA; 1 and 10 microM).	Tetradecanoylphorbol Acetate	142-173	protein kinase C, alpha	Rattus norvegicus	127-130
10578141-9	1999	4 The extent of cellular damage in response to addition of SNAP to the incubation medium was enhanced by coincubation with the PKC activator, phorbol 12-myristate 13-acetate (PMA; 1 and 10 microM).	Tetradecanoylphorbol Acetate	175-178	protein kinase C, alpha	Rattus norvegicus	127-130
2827513-1	1988	The influence of phorbol myristate acetate (PMA), an activator of protein kinase c, on the secretion of parathyroid hormone from collagenase-dispersed bovine parathyroid cells was tested.	Tetradecanoylphorbol Acetate	17-42	parathyroid hormone	Bos taurus	104-123
2827513-1	1988	The influence of phorbol myristate acetate (PMA), an activator of protein kinase c, on the secretion of parathyroid hormone from collagenase-dispersed bovine parathyroid cells was tested.	Tetradecanoylphorbol Acetate	44-47	parathyroid hormone	Bos taurus	104-123
10643587-7	1999	A PKC activator, 12-O-tetradecanoyl phorbol 13-acetate, decreased PAF-AH secretion.	Tetradecanoylphorbol Acetate	17-54	phospholipase A2 group VII	Homo sapiens	66-72
3142649-1	1988	Interrelationship between inflammation and ornithine decarboxylase activity induced in vitro by the carcinogenic 12-O-tetradecanoyl-phorbol-13-acetate].	Tetradecanoylphorbol Acetate	113-150	ornithine decarboxylase, structural 1	Mus musculus	43-66
10521422-2	1999	Here we show that in mouse Ltk(-) fibroblasts, calcium ionophore acts in synergy with either cAMP or PMA to strongly induce the endogenous c-fos gene.	Tetradecanoylphorbol Acetate	101-104	leukocyte tyrosine kinase	Mus musculus	27-30
10899920-7	2000	It is interesting that the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA), which induces the synthesis of PGs in many tissues, inhibited the increase in L-PGDS expression induced by dexamethasone.	Tetradecanoylphorbol Acetate	42-79	prostaglandin D2 synthase (brain)	Mus musculus	165-171
10899920-7	2000	It is interesting that the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA), which induces the synthesis of PGs in many tissues, inhibited the increase in L-PGDS expression induced by dexamethasone.	Tetradecanoylphorbol Acetate	81-84	prostaglandin D2 synthase (brain)	Mus musculus	165-171
3142649-2	1988	Topical application of 2 micrograms 12-O-tetradecanoyl-phorbol-13-acetate (TPA) regularly induced two early events in mouse skin: inflammatory reaction localized in dermal compartment and stimulation of ornithine decarboxylase activity in epidermal cells, in relation to polyamine synthesis and cell division.	Tetradecanoylphorbol Acetate	36-73	ornithine decarboxylase, structural 1	Mus musculus	203-226
10880381-6	2000	Topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) induced strong VEGF-GFP expression in suprabasal epidermis.	Tetradecanoylphorbol Acetate	23-59	vascular endothelial growth factor A	Mus musculus	81-85
10502285-8	1999	Furthermore, both RA and 1,25-D3, but not PGD2 abolish the induction of Tn-C by the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate.	Tetradecanoylphorbol Acetate	99-136	tenascin C	Rattus norvegicus	72-76
3142649-2	1988	Topical application of 2 micrograms 12-O-tetradecanoyl-phorbol-13-acetate (TPA) regularly induced two early events in mouse skin: inflammatory reaction localized in dermal compartment and stimulation of ornithine decarboxylase activity in epidermal cells, in relation to polyamine synthesis and cell division.	Tetradecanoylphorbol Acetate	75-78	ornithine decarboxylase, structural 1	Mus musculus	203-226
10880381-6	2000	Topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) induced strong VEGF-GFP expression in suprabasal epidermis.	Tetradecanoylphorbol Acetate	61-64	vascular endothelial growth factor A	Mus musculus	81-85
3142649-5	1988	At this stage, another TPA treatment induced a strong ODC activity concurrent with severe inflammation of the dermis.	Tetradecanoylphorbol Acetate	23-26	ornithine decarboxylase, structural 1	Mus musculus	54-57
3142649-6	1988	Inhibition of the synthesis of inflammatory factors may antagonize TPA-induced ODC, but the protective potencies differs according to the evolutive stages of the cell.	Tetradecanoylphorbol Acetate	67-70	ornithine decarboxylase, structural 1	Mus musculus	79-82
10514437-4	1999	Because previous studies have indicated that exposure of JB6 Cl 41 cells to either 12-O-tetradecanoylphorbol-13-acetate (TPA) or tumor necrosis factor-alpha (TNF-alpha) results in cell transformation, we investigated the role of JNKs in this biological process by using dominant negative JNK(1) and the cell transformation model JB6 Cl 41 cells.	Tetradecanoylphorbol Acetate	121-124	mitogen-activated protein kinase 8	Mus musculus	288-294
10889170-10	2000	Phorbol myristate acetate and phenylephrine triggered translocation of PKC-alpha and PKC-delta isoforms from the cytosol to the membrane in control aortas; in cirrhotic aortas, only PKC-alpha was translocated.	Tetradecanoylphorbol Acetate	0-25	protein kinase C, alpha	Rattus norvegicus	71-80
3142649-7	1988	After the first TPA treatment the anti-inflammatory compounds dexamethasone and indomethacin effectively inhibited ODC activity.	Tetradecanoylphorbol Acetate	16-19	ornithine decarboxylase, structural 1	Mus musculus	115-118
10889170-10	2000	Phorbol myristate acetate and phenylephrine triggered translocation of PKC-alpha and PKC-delta isoforms from the cytosol to the membrane in control aortas; in cirrhotic aortas, only PKC-alpha was translocated.	Tetradecanoylphorbol Acetate	0-25	protein kinase C, gamma	Rattus norvegicus	71-74
2964282-8	1988	These results suggest different mechanisms of action of TPA and DDT on metabolic cooperation and support the hypothesis that with calcium CaM may be of importance for drug-induced inhibition of intercellular communication and tumour promotion.	Tetradecanoylphorbol Acetate	56-59	LOC100759184	Cricetulus griseus	138-141
10889170-10	2000	Phorbol myristate acetate and phenylephrine triggered translocation of PKC-alpha and PKC-delta isoforms from the cytosol to the membrane in control aortas; in cirrhotic aortas, only PKC-alpha was translocated.	Tetradecanoylphorbol Acetate	0-25	protein kinase C, alpha	Rattus norvegicus	182-191
10914330-2	2000	The phorbol ester TPA reduced SP-A1 and SP-A2 promoter activity to approximately 35% to 45% compared to that of control cells.	Tetradecanoylphorbol Acetate	18-21	surfactant protein A2	Homo sapiens	40-45
10914330-4	2000	Using NCI-H441 nuclear proteins, electromobility shift assay analysis showed that the intron region +309/+329 of SP-A1 and the corresponding region of SP-A2 formed sequence-specific DNA/protein complexes that were induced by TPA exposure.	Tetradecanoylphorbol Acetate	225-228	surfactant protein A2	Homo sapiens	151-156
10508860-7	1999	By monitoring fluorescent recombinant protein and by gel mobility shift assays, PS1 was shown to accelerate the translocation of QM from the cytoplasm to the nucleus and to thereby suppress the binding of c-Jun homodimer to 12-O-tetradecanoylphorbol-13- acetate (TPA)-responsive element (TRE).	Tetradecanoylphorbol Acetate	224-261	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	205-210
10508860-7	1999	By monitoring fluorescent recombinant protein and by gel mobility shift assays, PS1 was shown to accelerate the translocation of QM from the cytoplasm to the nucleus and to thereby suppress the binding of c-Jun homodimer to 12-O-tetradecanoylphorbol-13- acetate (TPA)-responsive element (TRE).	Tetradecanoylphorbol Acetate	263-266	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	205-210
10914330-5	2000	The region +318/+324 of SP-A1 contains sequences similar to a consensus AP-1 binding site, TGACTGA (TCACTGA for SP-A2), which when mutated (TGAGAGT) prevented the formation of the TPA-induced DNA/protein complex.	Tetradecanoylphorbol Acetate	180-183	surfactant protein A2	Homo sapiens	112-117
2850161-2	1988	In the presence of 100 micrograms/ml eglin-c, the activation time was prolonged and the maximum linear rate of O-2 formation was depressed following stimulation with PMA; a concentration of 1000 micrograms/ml eglin-c was required to produce a similar effect with opsonized zymosan.	Tetradecanoylphorbol Acetate	166-169	immunoglobulin kappa variable 1D-39	Homo sapiens	111-114
11002391-5	2000	Phenotyping of U937 cells for complement receptors (CRs) and Fcgamma receptors (FcgammaRs) showed that interferon gamma (INFgamma) increased expression of FcgammaRI, CR3 (CD11b/CD18) and CR4 (CD11c/CD18) and that phorbol-12-myristate-13-acetate (PMA) increased expression of CR4.	Tetradecanoylphorbol Acetate	213-244	integrin subunit alpha M	Homo sapiens	171-176
10534117-6	1999	In transient transfection assays, PMA and NaB both stimulate transcription of the luciferase reporter gene placed under the control of ctsb promoter fragments.	Tetradecanoylphorbol Acetate	34-37	cathepsin B	Homo sapiens	135-139
3234856-1	1988	The effect of phorbol-12-myristate-13-acetate (PMA), an activator of protein kinase C (PK-C) on lipid peroxidation (LPO) in rat liver homogenates and microsomes was studied.	Tetradecanoylphorbol Acetate	14-45	protein kinase C, gamma	Rattus norvegicus	69-85
10629861-5	1999	Short-time (10-20 min) treatment with phorbol 12-myristate 13-acetate (PMA) induced translocation of PKC alpha from cytosolic to particulate fraction.	Tetradecanoylphorbol Acetate	38-69	protein kinase C, alpha	Rattus norvegicus	101-110
10629861-5	1999	Short-time (10-20 min) treatment with phorbol 12-myristate 13-acetate (PMA) induced translocation of PKC alpha from cytosolic to particulate fraction.	Tetradecanoylphorbol Acetate	71-74	protein kinase C, alpha	Rattus norvegicus	101-110
10629861-6	1999	PKC alpha was completely downregulated by treatment with 100 nM PMA for 24 hours.	Tetradecanoylphorbol Acetate	64-67	protein kinase C, alpha	Rattus norvegicus	0-9
10903418-0	2000	Inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin ornithine decarboxylase and protein kinase C by polyphenolics from grapes.	Tetradecanoylphorbol Acetate	14-50	ornithine decarboxylase, structural 1	Mus musculus	76-99
10903418-0	2000	Inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin ornithine decarboxylase and protein kinase C by polyphenolics from grapes.	Tetradecanoylphorbol Acetate	52-55	ornithine decarboxylase, structural 1	Mus musculus	76-99
10903418-3	2000	The present studies were designed to further characterize the effect of time and dose of application of GPF on TPA-induced ODC activity and protein expression, and on protein kinase C activity in mouse skin epidermis.	Tetradecanoylphorbol Acetate	111-114	ornithine decarboxylase, structural 1	Mus musculus	123-126
10903418-8	2000	Application of grape polyphenolics (20 mg) at 60 and 30 min prior to treatment with TPA inhibited ODC activity by 62 and 68%, respectively, compared with controls (P&lt;0.05).	Tetradecanoylphorbol Acetate	84-87	ornithine decarboxylase, structural 1	Mus musculus	98-101
3234856-1	1988	The effect of phorbol-12-myristate-13-acetate (PMA), an activator of protein kinase C (PK-C) on lipid peroxidation (LPO) in rat liver homogenates and microsomes was studied.	Tetradecanoylphorbol Acetate	14-45	protein kinase C, gamma	Rattus norvegicus	87-91
3234856-1	1988	The effect of phorbol-12-myristate-13-acetate (PMA), an activator of protein kinase C (PK-C) on lipid peroxidation (LPO) in rat liver homogenates and microsomes was studied.	Tetradecanoylphorbol Acetate	47-50	protein kinase C, gamma	Rattus norvegicus	69-85
10484327-3	1999	The effect of quercetin on ICAM-1 expression induced by agonists phorbol 12-myristate 13-acetate (PMA) and tumor necrosis factor-alpha (TNF-alpha) in human endothelial cell line ECV304 (ECV) was investigated.	Tetradecanoylphorbol Acetate	65-96	intercellular adhesion molecule 1	Homo sapiens	27-33
3234856-1	1988	The effect of phorbol-12-myristate-13-acetate (PMA), an activator of protein kinase C (PK-C) on lipid peroxidation (LPO) in rat liver homogenates and microsomes was studied.	Tetradecanoylphorbol Acetate	47-50	protein kinase C, gamma	Rattus norvegicus	87-91
10484327-3	1999	The effect of quercetin on ICAM-1 expression induced by agonists phorbol 12-myristate 13-acetate (PMA) and tumor necrosis factor-alpha (TNF-alpha) in human endothelial cell line ECV304 (ECV) was investigated.	Tetradecanoylphorbol Acetate	98-101	intercellular adhesion molecule 1	Homo sapiens	27-33
10871846-5	2000	We showed that H-ras null mutant mice develop approximately six times less papillomas compared with wild-type littermates after 20 weeks of TPA treatment.	Tetradecanoylphorbol Acetate	140-143	Harvey rat sarcoma virus oncogene	Mus musculus	15-20
10871841-13	2000	This work shows that annexin V overexpression suppresses the TPA-induced Ras/ERK signaling by inhibiting at/or upstream of Shc, possibly through the inhibition of PKCs.	Tetradecanoylphorbol Acetate	61-64	SHC adaptor protein 1	Homo sapiens	123-126
10469612-13	1999	In summary, our data indicate that: (i) 79% of the BP/TPA skin tumors in CD-1 mice had c-Ha-ras mutations for the combined data for high dose and low dose tumors; (ii) the major mutations detected in BP/TPA skin tumors were G--&gt;T transversions; (iii) the global mutation profile in the c-Ha-ras proto-oncogene in skin tumors obtained after initiation with a low dose of BP was different from that obtained after initiation with a high dose of BP.	Tetradecanoylphorbol Acetate	54-57	Harvey rat sarcoma virus oncogene	Mus musculus	87-95
3234856-2	1988	PMA (10(-10) to 10(-6) M) produced a concentration-dependent inhibition of LPO, which was greatly decreased by polymyxin B (PxB) (an inhibitor of PK-C).	Tetradecanoylphorbol Acetate	0-3	protein kinase C, gamma	Rattus norvegicus	146-150
10469619-3	1999	Therefore, we assessed the anti-tumor-promoting effect of a polyphenolic fraction isolated from grape seeds (GSP) employing the 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol 13-acetate (TPA)-promoted SENCAR mouse skin two-stage carcinogenesis protocol as a model system.	Tetradecanoylphorbol Acetate	218-221	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	109-112
2465997-2	1988	Short-term treatment of cells with phorbol-12-myristate-13-acetate (PMA) increased GFAP mRNA levels, but prolonged treatment of cells with PMA or 1-oleoyl-2-acetyl-rac-glycerol produced a dramatic decrease in GFAP mRNA; 4-beta-phorbol had no effect.	Tetradecanoylphorbol Acetate	35-66	glial fibrillary acidic protein	Homo sapiens	83-87
10465281-3	1999	Forskolin (Fsk, 10 microM) or 12-O-tetradecanoyl-phorbol 13-acetate (TPA, 100 nM) increases CRH-BP mRNA levels up to 30 times control level, and together they act synergistically to increase CRH-BP gene expression up to 100 times control levels.	Tetradecanoylphorbol Acetate	30-67	corticotropin releasing hormone binding protein	Rattus norvegicus	92-98
10816429-9	2000	In contrast, phosphatidylinositol 3-kinase (PI 3-kinase) and protein kinase B (PKB) activation by insulin and HGF is strong and sustained, whereas it is weak and transient with EGF and absent in the presence of TSH or PMA.	Tetradecanoylphorbol Acetate	218-221	insulin	Canis lupus familiaris	98-105
10879623-3	2000	In another set of experiments, the hearts pretreated with and without a PKC activator PMA (15 pmol/5 min) were subjected to the sustained ischemia and reperfusion.	Tetradecanoylphorbol Acetate	86-89	protein kinase C, gamma	Rattus norvegicus	72-75
2465997-2	1988	Short-term treatment of cells with phorbol-12-myristate-13-acetate (PMA) increased GFAP mRNA levels, but prolonged treatment of cells with PMA or 1-oleoyl-2-acetyl-rac-glycerol produced a dramatic decrease in GFAP mRNA; 4-beta-phorbol had no effect.	Tetradecanoylphorbol Acetate	35-66	glial fibrillary acidic protein	Homo sapiens	209-213
2465997-2	1988	Short-term treatment of cells with phorbol-12-myristate-13-acetate (PMA) increased GFAP mRNA levels, but prolonged treatment of cells with PMA or 1-oleoyl-2-acetyl-rac-glycerol produced a dramatic decrease in GFAP mRNA; 4-beta-phorbol had no effect.	Tetradecanoylphorbol Acetate	68-71	glial fibrillary acidic protein	Homo sapiens	83-87
10889466-6	2000	12-O-Tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC)-activating phorbol ester, stimulated VEGF secretion.	Tetradecanoylphorbol Acetate	0-36	vascular endothelial growth factor A	Mus musculus	106-110
2465997-2	1988	Short-term treatment of cells with phorbol-12-myristate-13-acetate (PMA) increased GFAP mRNA levels, but prolonged treatment of cells with PMA or 1-oleoyl-2-acetyl-rac-glycerol produced a dramatic decrease in GFAP mRNA; 4-beta-phorbol had no effect.	Tetradecanoylphorbol Acetate	68-71	glial fibrillary acidic protein	Homo sapiens	209-213
10889466-6	2000	12-O-Tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC)-activating phorbol ester, stimulated VEGF secretion.	Tetradecanoylphorbol Acetate	38-41	vascular endothelial growth factor A	Mus musculus	106-110
10465281-3	1999	Forskolin (Fsk, 10 microM) or 12-O-tetradecanoyl-phorbol 13-acetate (TPA, 100 nM) increases CRH-BP mRNA levels up to 30 times control level, and together they act synergistically to increase CRH-BP gene expression up to 100 times control levels.	Tetradecanoylphorbol Acetate	30-67	corticotropin releasing hormone binding protein	Rattus norvegicus	191-197
3283748-5	1988	In conclusion, the results presented indicate that the inhibition of TPA-induced ODC gene expression may be one of the mechanisms contributing to the antitumor promoting property of the retinoids.	Tetradecanoylphorbol Acetate	69-72	ornithine decarboxylase, structural 1	Mus musculus	81-84
10465281-3	1999	Forskolin (Fsk, 10 microM) or 12-O-tetradecanoyl-phorbol 13-acetate (TPA, 100 nM) increases CRH-BP mRNA levels up to 30 times control level, and together they act synergistically to increase CRH-BP gene expression up to 100 times control levels.	Tetradecanoylphorbol Acetate	69-72	corticotropin releasing hormone binding protein	Rattus norvegicus	92-98
10465281-3	1999	Forskolin (Fsk, 10 microM) or 12-O-tetradecanoyl-phorbol 13-acetate (TPA, 100 nM) increases CRH-BP mRNA levels up to 30 times control level, and together they act synergistically to increase CRH-BP gene expression up to 100 times control levels.	Tetradecanoylphorbol Acetate	69-72	corticotropin releasing hormone binding protein	Rattus norvegicus	191-197
10465281-7	1999	CRH-BP hnRNA transcripts can be detected transiently after the addition of Fsk or TPA, and dexamethasone can repress Fsk- or TPA-induced CRH-BP hnRNA levels in this assay.	Tetradecanoylphorbol Acetate	82-85	corticotropin releasing hormone binding protein	Rattus norvegicus	0-6
10465281-7	1999	CRH-BP hnRNA transcripts can be detected transiently after the addition of Fsk or TPA, and dexamethasone can repress Fsk- or TPA-induced CRH-BP hnRNA levels in this assay.	Tetradecanoylphorbol Acetate	125-128	corticotropin releasing hormone binding protein	Rattus norvegicus	137-143
10959625-8	2000	Since TPA is capable of stimulating the expression of cyclin D1 not only through TRE but also through CRE and NF-kappaB response element in the promoter, we tentatively propose a sequence of events that possibly leads to TPA-induced, anchorage-independent synthesis of cyclins D1 and A in the promotion-sensitive JB6 mouse epidermal cells.	Tetradecanoylphorbol Acetate	221-224	cyclin D1	Mus musculus	54-63
10848972-4	2000	Actinomycin D abolished the TPA-induced adrenomedullin expression, indicating that the induction of ADM gene expression by TPA was regulated at the transcriptional level.	Tetradecanoylphorbol Acetate	28-31	adrenomedullin	Homo sapiens	40-54
10848972-4	2000	Actinomycin D abolished the TPA-induced adrenomedullin expression, indicating that the induction of ADM gene expression by TPA was regulated at the transcriptional level.	Tetradecanoylphorbol Acetate	28-31	adrenomedullin	Homo sapiens	100-103
10848972-4	2000	Actinomycin D abolished the TPA-induced adrenomedullin expression, indicating that the induction of ADM gene expression by TPA was regulated at the transcriptional level.	Tetradecanoylphorbol Acetate	123-126	adrenomedullin	Homo sapiens	40-54
10848972-4	2000	Actinomycin D abolished the TPA-induced adrenomedullin expression, indicating that the induction of ADM gene expression by TPA was regulated at the transcriptional level.	Tetradecanoylphorbol Acetate	123-126	adrenomedullin	Homo sapiens	100-103
3121727-6	1987	When added directly into cultures of T cells stimulated with concanavalin A or by the combination of ionomycin with the protein kinase C activator phorbol myristate acetate (PMA), the H-22.10 mAb inhibited Ly-6A/E enhancement without affecting the blastogenesis or the emergence of interleukin 2 receptors and transferrin receptors.	Tetradecanoylphorbol Acetate	174-177	lymphocyte antigen 6 complex, locus A	Mus musculus	206-213
10848972-5	2000	Transient transfection assay revealed that a cis-acting region (positions -70 to -30) of human adrenomedullin gene was necessary for TPA-induced reporter gene expression.	Tetradecanoylphorbol Acetate	133-136	adrenomedullin	Homo sapiens	95-109
10848972-9	2000	These results indicate that the region (-70 to -30) of the human ADM gene containing multiple AP-2 binding sites is responsible for TPA-induced adrenomedullin expression in THP-1 cells.	Tetradecanoylphorbol Acetate	132-135	adrenomedullin	Homo sapiens	65-68
10848972-9	2000	These results indicate that the region (-70 to -30) of the human ADM gene containing multiple AP-2 binding sites is responsible for TPA-induced adrenomedullin expression in THP-1 cells.	Tetradecanoylphorbol Acetate	132-135	transcription factor AP-2 alpha	Homo sapiens	94-98
10848972-9	2000	These results indicate that the region (-70 to -30) of the human ADM gene containing multiple AP-2 binding sites is responsible for TPA-induced adrenomedullin expression in THP-1 cells.	Tetradecanoylphorbol Acetate	132-135	adrenomedullin	Homo sapiens	144-158
3677097-6	1987	The topical application of 4 mumol of ascorbyl palmitate inhibited by 60-76% the induction of epidermal ornithine decarboxylase activity and DNA synthesis that occurred after a single topical application of 2 nmol of TPA whereas similar doses of ascorbic acid had no inhibitory effect.	Tetradecanoylphorbol Acetate	217-220	ornithine decarboxylase, structural 1	Mus musculus	104-127
3677084-2	1987	The antiinflammatory steroid fluocinolone acetonide, an inhibitor of TPA-induced hyperplasia, as well as the multiple stages of tumor promotion as defined in SENCAR mice (Stages I and II), inhibited the TPA-dependent elevation of epidermal XO activity.	Tetradecanoylphorbol Acetate	203-206	xanthine dehydrogenase	Mus musculus	240-242
3677084-6	1987	Multiple treatments with TPA or ethyl phenylpropiolate resulted in a sustained elevation of XO activity which peaked at five treatments and then declined.	Tetradecanoylphorbol Acetate	25-28	xanthine dehydrogenase	Mus musculus	92-94
3677084-9	1987	These results suggest that the TPA-dependent elevation of epidermal XO activity is associated with the hyperplasia induced by the agent, and is a consequence of the hyperplasia rather than the cause of it.	Tetradecanoylphorbol Acetate	31-34	xanthine dehydrogenase	Mus musculus	68-70
3500223-4	1987	We found that in all three types of lysis (direct, lectin-mediated lysis, C or phorbol myristate acetate-induced) the requirement for Ca2+ in lysis was dictated by the target cell used; the same CTL can kill one target cell in the absence of detectable Ca2+, and absolutely require Ca2+ for the lysis of another target cell.	Tetradecanoylphorbol Acetate	79-104	carbonic anhydrase 2	Homo sapiens	134-137
3125055-0	1987	The induction of ornithine decarboxylase caused by 12-O-tetradecanoylphorbol-13-acetate in isolated epidermal cells is inhibited by lipoxygenase inhibitors but not by cyclooxygenase inhibitors.	Tetradecanoylphorbol Acetate	51-87	ornithine decarboxylase, structural 1	Mus musculus	17-40
3125055-1	1987	The effects of lipoxygenase and cyclooxygenase inhibitors on ornithine decarboxylase (ODC) induction by a potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) were examined in vitro in isolated mouse epidermal cells.	Tetradecanoylphorbol Acetate	129-165	ornithine decarboxylase, structural 1	Mus musculus	61-84
3125055-1	1987	The effects of lipoxygenase and cyclooxygenase inhibitors on ornithine decarboxylase (ODC) induction by a potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) were examined in vitro in isolated mouse epidermal cells.	Tetradecanoylphorbol Acetate	129-165	ornithine decarboxylase, structural 1	Mus musculus	86-89
3125055-1	1987	The effects of lipoxygenase and cyclooxygenase inhibitors on ornithine decarboxylase (ODC) induction by a potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) were examined in vitro in isolated mouse epidermal cells.	Tetradecanoylphorbol Acetate	167-170	ornithine decarboxylase, structural 1	Mus musculus	61-84
3125055-4	1987	These results suggest that the lipoxygenase inhibitors inhibit TPA-caused epidermal ODC induction in mouse skin at least in part by acting directly on epidermal cells while cyclooxygenase inhibitor inhibits it indirectly by acting on cells other than epidermal cells, e.g. cells which are involved in the prostaglandin-dependent inflammatory process.	Tetradecanoylphorbol Acetate	63-66	ornithine decarboxylase, structural 1	Mus musculus	84-87
2822168-7	1987	TPA induced the differentiation of the more mature pre-T-ALL cells of this case in vitro, and not only CD25 (Tac) antigen but also CD4 and CD8 antigens appeared on the cell surface.	Tetradecanoylphorbol Acetate	0-3	CD8a molecule	Homo sapiens	139-142
3433255-1	1987	PAF-likely activity, detected as aggregation of washed platelets, was found in the exudate of rats with pleurisy induced by phorbol myristate acetate (PMA, 1 nmol).	Tetradecanoylphorbol Acetate	124-149	PCNA clamp associated factor	Rattus norvegicus	0-3
3433255-1	1987	PAF-likely activity, detected as aggregation of washed platelets, was found in the exudate of rats with pleurisy induced by phorbol myristate acetate (PMA, 1 nmol).	Tetradecanoylphorbol Acetate	151-154	PCNA clamp associated factor	Rattus norvegicus	0-3
3433255-2	1987	At 30 min after the injection of PMA, 400-500 pg of PAF was detected in the pleural exudate.	Tetradecanoylphorbol Acetate	33-36	PCNA clamp associated factor	Rattus norvegicus	52-55
3621189-4	1987	In 1 alpha (OH)D3-treated mice, induction of epidermal ODC by 12-O-tetradecanoylphorbol-13-acetate was markedly inhibited, the inhibition being maximal 2 to 4 days after 1 alpha (OH)D3 administration.	Tetradecanoylphorbol Acetate	62-98	ornithine decarboxylase, structural 1	Mus musculus	55-58
3119989-2	1987	Induction by both EGF and TPA in HeLa cells required the presence of the c-fos enhancer located at -317 to -298 relative to the mRNA cap site.	Tetradecanoylphorbol Acetate	26-29	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78
3479682-10	1987	The phorbol ester tumor promoter tetradecanoyl phorbol acetate also increased PDGF A expression with similar kinetics, but with a mechanism distinct from that of TGF-beta.	Tetradecanoylphorbol Acetate	33-62	platelet derived growth factor subunit A	Homo sapiens	78-84
3612691-4	1987	The biological activity of these heteroarotinoids was assayed by either the suppression of the 12-O-tetradecanoylphorbol 13-acetate (TPA) induced synthesis of ornithine decarboxylase (ODC) in mouse skin or the induction of differentiation of human (HL-60) promyelocytic cells.	Tetradecanoylphorbol Acetate	95-131	ornithine decarboxylase, structural 1	Mus musculus	159-182
3612691-4	1987	The biological activity of these heteroarotinoids was assayed by either the suppression of the 12-O-tetradecanoylphorbol 13-acetate (TPA) induced synthesis of ornithine decarboxylase (ODC) in mouse skin or the induction of differentiation of human (HL-60) promyelocytic cells.	Tetradecanoylphorbol Acetate	95-131	ornithine decarboxylase, structural 1	Mus musculus	184-187
3612691-4	1987	The biological activity of these heteroarotinoids was assayed by either the suppression of the 12-O-tetradecanoylphorbol 13-acetate (TPA) induced synthesis of ornithine decarboxylase (ODC) in mouse skin or the induction of differentiation of human (HL-60) promyelocytic cells.	Tetradecanoylphorbol Acetate	133-136	ornithine decarboxylase, structural 1	Mus musculus	159-182
3109744-1	1987	A cloned variant of the EL-4 murine T-cell line treated with phorbol myristate acetate (PMA) releases a factor that activates macrophages for nonspecific tumor cytotoxicity.	Tetradecanoylphorbol Acetate	61-86	epilepsy 4	Mus musculus	24-28
3109744-1	1987	A cloned variant of the EL-4 murine T-cell line treated with phorbol myristate acetate (PMA) releases a factor that activates macrophages for nonspecific tumor cytotoxicity.	Tetradecanoylphorbol Acetate	88-91	epilepsy 4	Mus musculus	24-28
3496224-3	1987	TPA stimulation of an interleukin 2 (IL 2)-producing variant, EL4+, induced a 3-4-fold increase in TCR beta, but not alpha, chain mRNA.	Tetradecanoylphorbol Acetate	0-3	epilepsy 4	Mus musculus	62-65
3496224-6	1987	TPA stimulation of EL4+ cells also induced de novo expression of the IL 2 gene and subsequent secretion of this lymphokine.	Tetradecanoylphorbol Acetate	0-3	epilepsy 4	Mus musculus	19-22
3036707-5	1987	Acetylcholine, nitroprusside, and atrial natriuretic factor induced relaxation in vascular smooth muscle contracted by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	119-155	natriuretic peptide A	Rattus norvegicus	34-59
3597558-0	1987	Differential induction of transcription of c-myc and c-fos proto-oncogenes by 12-O-tetradecanoylphorbol-13-acetate in mortal and immortal human urothelial cells.	Tetradecanoylphorbol Acetate	78-114	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	53-58
3597558-2	1987	A single treatment with TPA (1 microgram/ml) increased the transcription of c-fos and c-myc proto-oncogenes at least 20-fold in the mortal cell line HU 1752.	Tetradecanoylphorbol Acetate	24-27	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-81
3597558-4	1987	When immortalized cell lines were treated with TPA a similar rapid and transient morphological response was observed, but the TPA treatment only increased the level of c-fos mRNA, suggesting that the normal regulation of c-myc transcription is altered in immortalized cells irrespective of their tumorigenic properties.	Tetradecanoylphorbol Acetate	126-129	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	168-173
3475202-6	1987	The PDGF-A and B-chain (c-sis) RNA expression as well as secretion of PDGF polypeptides are induced in the K562 cell line upon induction of megakaryoblastic differentiation with 12-O-tetradecanoyl phorbol-13-acetate (TPA) whereas erythroid differentiation induced with sodium butyrate is accompanied by c-sis expression only.	Tetradecanoylphorbol Acetate	178-215	platelet derived growth factor subunit A	Homo sapiens	4-22
3815331-1	1987	Topical treatment of mouse skin with the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) results in an array of biochemical alterations, one of the earliest being a more than 200-fold transient induction of epidermal ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	63-99	ornithine decarboxylase, structural 1	Mus musculus	234-257
10458930-4	1999	Phorbol 12-myristate 13-acetate increased cPLA(2) activity and PGI(2) synthesis but failed to alter [Ca(2+)](i).	Tetradecanoylphorbol Acetate	0-31	phospholipase A2 group IVA	Homo sapiens	42-49
10444443-8	1999	Phorbol 12-myristate 13-acetate (PMA, 1 microM) acutely inhibited NHE3 activity by 28% of control, whereas epidermal growth factor (EGF, 200 ng/ml) stimulated the activity by 18%.	Tetradecanoylphorbol Acetate	0-31	solute carrier family 9 member A3	Homo sapiens	66-70
10444443-8	1999	Phorbol 12-myristate 13-acetate (PMA, 1 microM) acutely inhibited NHE3 activity by 28% of control, whereas epidermal growth factor (EGF, 200 ng/ml) stimulated the activity by 18%.	Tetradecanoylphorbol Acetate	33-36	solute carrier family 9 member A3	Homo sapiens	66-70
3815331-1	1987	Topical treatment of mouse skin with the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) results in an array of biochemical alterations, one of the earliest being a more than 200-fold transient induction of epidermal ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	63-99	ornithine decarboxylase, structural 1	Mus musculus	259-262
10849115-4	2000	Pretreatment of neutrophils with phorbol myristate acetate caused a marked decrease in the expression of L-selectin on neutrophils from both normal and BLAD calves.	Tetradecanoylphorbol Acetate	33-58	L-selectin	Bos taurus	105-115
3815331-1	1987	Topical treatment of mouse skin with the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) results in an array of biochemical alterations, one of the earliest being a more than 200-fold transient induction of epidermal ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	101-104	ornithine decarboxylase, structural 1	Mus musculus	234-257
3815331-1	1987	Topical treatment of mouse skin with the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) results in an array of biochemical alterations, one of the earliest being a more than 200-fold transient induction of epidermal ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	101-104	ornithine decarboxylase, structural 1	Mus musculus	259-262
3815331-2	1987	There is an excellent correlation between the induction of epidermal ODC activity and changes in the level of immunoreactive ODC protein following a single TPA treatment to skin.	Tetradecanoylphorbol Acetate	156-159	ornithine decarboxylase, structural 1	Mus musculus	69-72
10444443-9	1999	The effect of PMA was abolished by the protein kinase C (PKC) inhibitor 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, suggesting involvement of PKC in the PMA-induced inhibition of NHE3.	Tetradecanoylphorbol Acetate	14-17	solute carrier family 9 member A3	Homo sapiens	183-187
10444443-9	1999	The effect of PMA was abolished by the protein kinase C (PKC) inhibitor 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, suggesting involvement of PKC in the PMA-induced inhibition of NHE3.	Tetradecanoylphorbol Acetate	157-160	solute carrier family 9 member A3	Homo sapiens	183-187
10874208-6	2000	Induction of skin tumors was significantly accelerated in the DMA-treated group, as well as in the TPA-treated group, indicating that DMA has a promoting effect on skin tumorigenesis in K6 / ODC transgenic mice.	Tetradecanoylphorbol Acetate	99-102	ornithine decarboxylase, structural 1	Mus musculus	191-194
3815331-2	1987	There is an excellent correlation between the induction of epidermal ODC activity and changes in the level of immunoreactive ODC protein following a single TPA treatment to skin.	Tetradecanoylphorbol Acetate	156-159	ornithine decarboxylase, structural 1	Mus musculus	125-128
3815331-3	1987	Both ODC activity and protein levels peak at 4.5 h after TPA treatment and rapidly fall to basal levels by 24 h. Cycloheximide treatment of mice in which ODC had been previously induced by TPA indicated a similar rapid turnover of both ODC catalytic activity and protein levels.	Tetradecanoylphorbol Acetate	57-60	ornithine decarboxylase, structural 1	Mus musculus	5-8
10444518-2	1999	Such agents include 12-O-tetradecanoylphorbol 13-acetate (TPA) and cell-permeable diacylglycerols that directly activate PKC.	Tetradecanoylphorbol Acetate	20-56	protein kinase C, alpha	Rattus norvegicus	121-124
3815331-3	1987	Both ODC activity and protein levels peak at 4.5 h after TPA treatment and rapidly fall to basal levels by 24 h. Cycloheximide treatment of mice in which ODC had been previously induced by TPA indicated a similar rapid turnover of both ODC catalytic activity and protein levels.	Tetradecanoylphorbol Acetate	189-192	ornithine decarboxylase, structural 1	Mus musculus	5-8
3815331-3	1987	Both ODC activity and protein levels peak at 4.5 h after TPA treatment and rapidly fall to basal levels by 24 h. Cycloheximide treatment of mice in which ODC had been previously induced by TPA indicated a similar rapid turnover of both ODC catalytic activity and protein levels.	Tetradecanoylphorbol Acetate	189-192	ornithine decarboxylase, structural 1	Mus musculus	154-157
10772818-5	2000	Both TPA and NGF induced a sustained activation and nuclear accumulation of ERK that was accompanied by transactivation of a serum response element (SRE)-driven reporter and of the c-fos gene.	Tetradecanoylphorbol Acetate	5-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	181-186
3815331-3	1987	Both ODC activity and protein levels peak at 4.5 h after TPA treatment and rapidly fall to basal levels by 24 h. Cycloheximide treatment of mice in which ODC had been previously induced by TPA indicated a similar rapid turnover of both ODC catalytic activity and protein levels.	Tetradecanoylphorbol Acetate	189-192	ornithine decarboxylase, structural 1	Mus musculus	154-157
10468798-5	1999	SDZ ASM 981 inhibits the phorbol myristate acetate/phytohaemagglutinin-stimulated transcription of a reporter gene coupled to the human IL-2 promoter in the human T-cell line Jurkat and the IgE/antigen-mediated transcription of a reporter gene coupled to the human tumour necrosis factor (TNF)-alpha promoter in the murine mast-cell line CPII.	Tetradecanoylphorbol Acetate	25-50	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	4-7
3815331-4	1987	Northern blot analysis of polyadenylated RNA isolated from mouse epidermis after a single TPA treatment revealed the stimulation of one species of ODC mRNA of 2.0 kilobases with a maximum at 3.5 h declining by 16 h. The same-sized species of ODC mRNA was detected 4.5 h after multiple biweekly treatments with TPA as well as in mouse papillomas and carcinomas not treated with TPA for at least 1 week.	Tetradecanoylphorbol Acetate	90-93	ornithine decarboxylase, structural 1	Mus musculus	147-150
3815331-4	1987	Northern blot analysis of polyadenylated RNA isolated from mouse epidermis after a single TPA treatment revealed the stimulation of one species of ODC mRNA of 2.0 kilobases with a maximum at 3.5 h declining by 16 h. The same-sized species of ODC mRNA was detected 4.5 h after multiple biweekly treatments with TPA as well as in mouse papillomas and carcinomas not treated with TPA for at least 1 week.	Tetradecanoylphorbol Acetate	90-93	ornithine decarboxylase, structural 1	Mus musculus	242-245
10482923-3	1999	Here, we have investigated the particular protein kinase C (PKC) isoform(s) responsible for the inhibition of P2Y1 and P2Y2 receptor-evoked inositol phosphate (IP) formation by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	177-208	protein kinase C alpha	Bos taurus	60-63
10800949-1	2000	Synaptosomal-associated protein of 25 kDa (SNAP-25), a t-SNARE protein essential for neurotransmitter release, is phosphorylated at Ser187 following activation of cellular protein kinase C by treatment with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	207-238	synaptosome associated protein 25	Rattus norvegicus	0-41
3815331-4	1987	Northern blot analysis of polyadenylated RNA isolated from mouse epidermis after a single TPA treatment revealed the stimulation of one species of ODC mRNA of 2.0 kilobases with a maximum at 3.5 h declining by 16 h. The same-sized species of ODC mRNA was detected 4.5 h after multiple biweekly treatments with TPA as well as in mouse papillomas and carcinomas not treated with TPA for at least 1 week.	Tetradecanoylphorbol Acetate	310-313	ornithine decarboxylase, structural 1	Mus musculus	147-150
10800949-1	2000	Synaptosomal-associated protein of 25 kDa (SNAP-25), a t-SNARE protein essential for neurotransmitter release, is phosphorylated at Ser187 following activation of cellular protein kinase C by treatment with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	207-238	synaptosome associated protein 25	Rattus norvegicus	43-50
10753872-3	2000	It is further shown that FTI inhibits p70s6k activation in response to serum, phorbol myristate acetate, and increased amino acid levels.	Tetradecanoylphorbol Acetate	78-103	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	38-44
10482923-3	1999	Here, we have investigated the particular protein kinase C (PKC) isoform(s) responsible for the inhibition of P2Y1 and P2Y2 receptor-evoked inositol phosphate (IP) formation by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	210-213	protein kinase C alpha	Bos taurus	60-63
10482923-10	1999	Pretreatment of the selective PKC inhibitor Ro 31-8220 attenuated the inhibitory effect of PMA on IP formation.	Tetradecanoylphorbol Acetate	91-94	protein kinase C alpha	Bos taurus	30-33
3815331-4	1987	Northern blot analysis of polyadenylated RNA isolated from mouse epidermis after a single TPA treatment revealed the stimulation of one species of ODC mRNA of 2.0 kilobases with a maximum at 3.5 h declining by 16 h. The same-sized species of ODC mRNA was detected 4.5 h after multiple biweekly treatments with TPA as well as in mouse papillomas and carcinomas not treated with TPA for at least 1 week.	Tetradecanoylphorbol Acetate	310-313	ornithine decarboxylase, structural 1	Mus musculus	147-150
10739673-5	2000	Downregulation of c-myc mRNA and upregulation of c-fos and egr-1 mRNA and protein, which normally occur during TPA-induced differentiation, were not affected by inclusion of the protease inhibitors.	Tetradecanoylphorbol Acetate	111-114	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-54
3815331-6	1987	These observations indicate that the induction of epidermal ODC activity following TPA treatment results in a transient increase in the steady state levels of ODC mRNA and in the rate of synthesis of ODC protein, in contrast to epidermal tumors where the levels of ODC mRNA and protein are constitutively elevated.	Tetradecanoylphorbol Acetate	83-86	ornithine decarboxylase, structural 1	Mus musculus	60-63
10739673-6	2000	These data indicate that serine proteases specifically mediate many of the phenotypic aspects of TPA-induced monocytic differentiation but are not involved with the induction or repression of differentiation-sensitive transcription factors and suggest that serine protease activity is required for intracellular processing of CD11b.	Tetradecanoylphorbol Acetate	97-100	integrin subunit alpha M	Homo sapiens	326-331
3815331-6	1987	These observations indicate that the induction of epidermal ODC activity following TPA treatment results in a transient increase in the steady state levels of ODC mRNA and in the rate of synthesis of ODC protein, in contrast to epidermal tumors where the levels of ODC mRNA and protein are constitutively elevated.	Tetradecanoylphorbol Acetate	83-86	ornithine decarboxylase, structural 1	Mus musculus	159-162
10775036-3	2000	The effect of phorbol 12-myristate 13-acetate (PMA) on cell differentiation and signal transduction in a human myeloid leukemia cell line, TF-1a, was investigated.	Tetradecanoylphorbol Acetate	14-45	tripartite motif containing 24	Homo sapiens	139-144
10482923-11	1999	Go 6976 (an inhibitor of conventional PKCalpha, beta and gamma) and LY 379196 (a selective PKCbeta inhibitor) also dose-dependently inhibited the PMA-mediated desensitization.	Tetradecanoylphorbol Acetate	146-149	protein kinase C alpha	Bos taurus	38-62
10775036-3	2000	The effect of phorbol 12-myristate 13-acetate (PMA) on cell differentiation and signal transduction in a human myeloid leukemia cell line, TF-1a, was investigated.	Tetradecanoylphorbol Acetate	47-50	tripartite motif containing 24	Homo sapiens	139-144
3815331-6	1987	These observations indicate that the induction of epidermal ODC activity following TPA treatment results in a transient increase in the steady state levels of ODC mRNA and in the rate of synthesis of ODC protein, in contrast to epidermal tumors where the levels of ODC mRNA and protein are constitutively elevated.	Tetradecanoylphorbol Acetate	83-86	ornithine decarboxylase, structural 1	Mus musculus	159-162
10775036-5	2000	PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1.	Tetradecanoylphorbol Acetate	0-3	ETS transcription factor ELK1	Homo sapiens	257-262
3815331-6	1987	These observations indicate that the induction of epidermal ODC activity following TPA treatment results in a transient increase in the steady state levels of ODC mRNA and in the rate of synthesis of ODC protein, in contrast to epidermal tumors where the levels of ODC mRNA and protein are constitutively elevated.	Tetradecanoylphorbol Acetate	83-86	ornithine decarboxylase, structural 1	Mus musculus	159-162
10775036-5	2000	PMA treatment rapidly (10 min) induced phosphorylation of MAPK kinase (MEK and p44/42 MAPK), which persisted for at least 24 h. p44/42 MAPK immunoprecipitates from lysates of PMA-treated cells had increased ability to phosphorylate the transcription factor Elk-1.	Tetradecanoylphorbol Acetate	175-178	ETS transcription factor ELK1	Homo sapiens	257-262
3029561-2	1987	The levels of c-fos mRNA were dramatically increased by stimulation with phorbol myristate acetate (PMA), calcium ionophore, or 1-oleoyl-2-acetoyl glycerol (OAG).	Tetradecanoylphorbol Acetate	73-98	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
10803709-7	2000	TPA and bryostatin 1 decreased n-PKC delta expression, the intracellular melanin level and metastatic capacity in both cell lines.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, delta	Mus musculus	33-42
10678110-3	1999	RESULTS: Phorbol ester (PMA) enhanced the expression of ICAM-1 in a concentration (10-100 nmol.L-1) and time (4-16 h)-dependent manner in RBMEC.	Tetradecanoylphorbol Acetate	24-27	intercellular adhesion molecule 1	Rattus norvegicus	56-62
10419502-8	1999	In addition, 12-O-tetradecanoylphorbol-13-acetate-induced activation of Ral is completely abolished by inhibitors of protein kinase C, whereas 12-O-tetradecanoylphorbol-13-acetate-induced Ras activation is largely insensitive.	Tetradecanoylphorbol Acetate	13-49	RAS like proto-oncogene A	Homo sapiens	72-75
3029561-2	1987	The levels of c-fos mRNA were dramatically increased by stimulation with phorbol myristate acetate (PMA), calcium ionophore, or 1-oleoyl-2-acetoyl glycerol (OAG).	Tetradecanoylphorbol Acetate	100-103	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
10472804-2	1999	AFB1 inhibited the phorbol-12myristate-13-acetate/i6nomycin (PMA/Io)-induced IL-2 mRNA expression in the murine thymocytes and Jurkat E6-1 cells as determined by qualitative RT-PCR, while no effect was observed in the EL4.IL-2 cells.	Tetradecanoylphorbol Acetate	19-49	epilepsy 4	Mus musculus	218-221
10772365-4	2000	Tissue plasminogen activator reduced the mean peak CL of macrophages exposed to PMA or ZMA by 20% and 36%, respectively (p=0.0008 and p=0.028, analysis of variance).	Tetradecanoylphorbol Acetate	80-83	chromosome 20 open reading frame 181	Homo sapiens	0-28
10472804-2	1999	AFB1 inhibited the phorbol-12myristate-13-acetate/i6nomycin (PMA/Io)-induced IL-2 mRNA expression in the murine thymocytes and Jurkat E6-1 cells as determined by qualitative RT-PCR, while no effect was observed in the EL4.IL-2 cells.	Tetradecanoylphorbol Acetate	61-64	epilepsy 4	Mus musculus	218-221
3098322-7	1987	Immunoglobulin heavy chain and T cell receptor beta-chain genes remained in germline configuration after treatment with TPA, when analyzed with JH and CT beta probes, respectively.	Tetradecanoylphorbol Acetate	120-123	phosphate cytidylyltransferase 1B, choline	Homo sapiens	151-158
10400642-3	1999	Here we show that this attenuation of tyrosine phosphorylation of Shc, CrkL, and the proto-oncogene Cbl is mimicked by treatment of mouse T lymphocytes or cultured Jurkat cells with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	182-213	src homology 2 domain-containing transforming protein C1	Mus musculus	66-69
10388538-8	1999	These results suggest that the inhibition of PMA-induced HA adhesion by IFN-gamma and IL-4 may influence B cell migration through their ability to downregulate CD44-HA interactions.	Tetradecanoylphorbol Acetate	45-48	CD44 molecule (Indian blood group)	Homo sapiens	160-164
10398310-9	1999	Co-expression of CD7 on CD34+ cells was induced to decrease significantly after short-term in vitro culture with the differentiation-inducing agent phorbol ester (PMA) and with a combination of cytokines (stem-cell factor, interleukin-3 and granulocyte colony-stimulating factor).	Tetradecanoylphorbol Acetate	163-166	CD7 molecule	Homo sapiens	17-20
10397633-1	1999	Cellular distribution and activation by phorbol myristate acetate (PMA) of classical (alpha, betaI, betaII,gamma), novel (delta, epsilon, theta, eta), and atypical (zeta, iota) protein kinase C (PKC) isoforms were studied in cultured rat neonatal microglial and astroglial cells by Western blot analysis.	Tetradecanoylphorbol Acetate	40-65	protein kinase C, gamma	Rattus norvegicus	177-193
10385697-6	1999	Transcriptional activation required the galanin 12-O-tetradecanoylphorbol-13-acetate (phorbol-12-myristate-13-acetate) response element (GTRE) octamer sequence (TGACGCGG) in the proximal enhancer of the GAL gene, previously shown to confer phorbol ester responsiveness in chromaffin cells.	Tetradecanoylphorbol Acetate	48-84	galanin and GMAP prepropeptide	Homo sapiens	40-47
10385697-6	1999	Transcriptional activation required the galanin 12-O-tetradecanoylphorbol-13-acetate (phorbol-12-myristate-13-acetate) response element (GTRE) octamer sequence (TGACGCGG) in the proximal enhancer of the GAL gene, previously shown to confer phorbol ester responsiveness in chromaffin cells.	Tetradecanoylphorbol Acetate	48-84	galanin and GMAP prepropeptide	Homo sapiens	203-206
10385697-6	1999	Transcriptional activation required the galanin 12-O-tetradecanoylphorbol-13-acetate (phorbol-12-myristate-13-acetate) response element (GTRE) octamer sequence (TGACGCGG) in the proximal enhancer of the GAL gene, previously shown to confer phorbol ester responsiveness in chromaffin cells.	Tetradecanoylphorbol Acetate	86-117	galanin and GMAP prepropeptide	Homo sapiens	40-47
10385697-6	1999	Transcriptional activation required the galanin 12-O-tetradecanoylphorbol-13-acetate (phorbol-12-myristate-13-acetate) response element (GTRE) octamer sequence (TGACGCGG) in the proximal enhancer of the GAL gene, previously shown to confer phorbol ester responsiveness in chromaffin cells.	Tetradecanoylphorbol Acetate	86-117	galanin and GMAP prepropeptide	Homo sapiens	203-206
10361238-4	1999	CD8+ T cell supernatants enhanced LTR-mediated gene expression in U38 cells activated with Tat in the absence or presence of phorbol myristate acetate (PMA) and ionomycin or TNF-alpha.	Tetradecanoylphorbol Acetate	152-155	CD8a molecule	Homo sapiens	0-3
10361238-4	1999	CD8+ T cell supernatants enhanced LTR-mediated gene expression in U38 cells activated with Tat in the absence or presence of phorbol myristate acetate (PMA) and ionomycin or TNF-alpha.	Tetradecanoylphorbol Acetate	125-150	CD8a molecule	Homo sapiens	0-3
10545022-0	1999	TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-alpha and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment.	Tetradecanoylphorbol Acetate	0-3	troponin I3, cardiac type	Homo sapiens	114-119
10545022-1	1999	We previously found that 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced invasiveness was associated with augmentation of cell motility but not that of metalloproteinase activity in a highly metastatic variant (L-10) of the human colon adenocarcinoma cell line RCM-1 and that this enhancement was possibly mediated by protein kinase C (PKC).	Tetradecanoylphorbol Acetate	25-61	troponin I3, cardiac type	Homo sapiens	265-270
10545022-1	1999	We previously found that 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced invasiveness was associated with augmentation of cell motility but not that of metalloproteinase activity in a highly metastatic variant (L-10) of the human colon adenocarcinoma cell line RCM-1 and that this enhancement was possibly mediated by protein kinase C (PKC).	Tetradecanoylphorbol Acetate	63-66	troponin I3, cardiac type	Homo sapiens	265-270
10400827-8	1999	Addition of PKC inhibitors reverses the PMA-mediated down-regulation of LPS-induced IL-10 secretion, indicating that PKC, once activated in vivo, might play a prominent role in controlling the secretion of IL-10 by AM.	Tetradecanoylphorbol Acetate	40-43	interleukin 10	Homo sapiens	84-89
10400827-8	1999	Addition of PKC inhibitors reverses the PMA-mediated down-regulation of LPS-induced IL-10 secretion, indicating that PKC, once activated in vivo, might play a prominent role in controlling the secretion of IL-10 by AM.	Tetradecanoylphorbol Acetate	40-43	interleukin 10	Homo sapiens	206-211
10365914-7	1999	Analysis of the IGF-1 receptor (IGF-1r) and epidermal growth factor (EGFr) in the epidermis of TPA-treated HK1.IGF-1 transgenic and non-transgenic mice revealed that both receptors were activated (hyperphosphorylated on tyrosine residues), and the level of activation was higher in transgenic mice.	Tetradecanoylphorbol Acetate	95-98	hexokinase 1	Mus musculus	107-110
10347243-6	1999	The involvement of PKC was further demonstrated by direct inhibition of GIRK currents by the phorbol esters, phorbol-12,13-dibutyrate and phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	138-169	potassium inwardly rectifying channel subfamily J member 3 S homeolog	Xenopus laevis	72-76
10344756-3	1999	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced immediate early genes, such as c-Jun, c-Fos, and Egr-1 in activated Ki-ras-disrupted clones, whereas c-Jun induction was rare in HCT116.	Tetradecanoylphorbol Acetate	0-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-87
10344756-3	1999	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced immediate early genes, such as c-Jun, c-Fos, and Egr-1 in activated Ki-ras-disrupted clones, whereas c-Jun induction was rare in HCT116.	Tetradecanoylphorbol Acetate	38-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-94
10344756-3	1999	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced immediate early genes, such as c-Jun, c-Fos, and Egr-1 in activated Ki-ras-disrupted clones, whereas c-Jun induction was rare in HCT116.	Tetradecanoylphorbol Acetate	38-41	KRAS proto-oncogene, GTPase	Homo sapiens	119-125
10344756-3	1999	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced immediate early genes, such as c-Jun, c-Fos, and Egr-1 in activated Ki-ras-disrupted clones, whereas c-Jun induction was rare in HCT116.	Tetradecanoylphorbol Acetate	38-41	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-87
10344756-4	1999	TPA induced both phosphorylation of stress-activated protein kinase kinase 1 (SEK1) and c-Jun NH2-terminal kinase (JNK) in the activated Ki-ras-disrupted clones but not in HCT116.	Tetradecanoylphorbol Acetate	0-3	KRAS proto-oncogene, GTPase	Homo sapiens	137-143
10344756-5	1999	On the other hand, TPA-induced mitogen-activated protein kinase kinase 1/2 (MEK1/2)-extracellular signal-regulated kinase (ERK) activation was equally induced between HCT116 and the Ki-ras-disrupted clones.	Tetradecanoylphorbol Acetate	19-22	KRAS proto-oncogene, GTPase	Homo sapiens	182-188
10344756-6	1999	Furthermore, TPA-induced SEK1-JNK activation was observed in a DLD-1-derived activated Ki-ras-disrupted clone but not in DLD-1.	Tetradecanoylphorbol Acetate	13-16	KRAS proto-oncogene, GTPase	Homo sapiens	87-93
10385256-10	1999	Tranilast inhibited phorbol myristate acetate (PMA)-dependent stimulation of [3H]-thymidine incorporation and VEGF- and PMA-induced gene expression of integrin alpha v and c-fos in BREC.	Tetradecanoylphorbol Acetate	47-50	vascular endothelial growth factor A	Bos taurus	110-114
10331422-8	1999	The protein kinase C (PKC) agonist phorbol myristate acetate (PMA) induced KDR mRNA expression 5.1-fold at 100 nmol/l.	Tetradecanoylphorbol Acetate	35-60	kinase insert domain receptor	Homo sapiens	75-78
10331422-8	1999	The protein kinase C (PKC) agonist phorbol myristate acetate (PMA) induced KDR mRNA expression 5.1-fold at 100 nmol/l.	Tetradecanoylphorbol Acetate	62-65	kinase insert domain receptor	Homo sapiens	75-78
10212240-10	1999	Furthermore, staurosporine did not inhibit internalization although it blocked phorbol 12-myristate 13-acetate-induced CCR-3 down-modulation.	Tetradecanoylphorbol Acetate	79-110	C-C motif chemokine receptor 3	Homo sapiens	119-124
10411311-7	1999	Overnight treatment with 4beta-phorbol 12-myristate 13-acetate, an activator of PKC, down-regulated PKC alpha, delta, and epsilon, but not PKC zeta.	Tetradecanoylphorbol Acetate	25-62	protein kinase C, alpha	Rattus norvegicus	80-83
10319997-2	1999	This is shown to be due to the inability of TPA to maintain activation of MAP/extracellular signal-regulated kinase kinase (MEK) and cRaf1.	Tetradecanoylphorbol Acetate	44-47	TNF receptor associated factor 3	Homo sapiens	133-138
10098498-6	1999	The Ca2+ ionophore, A23187 or ionomycin, mimicked the effect of AVP, whereas the protein kinase C (PKC) activator, TPA, only induced a slight increase in AA release.	Tetradecanoylphorbol Acetate	115-118	protein kinase C, alpha	Rattus norvegicus	99-102
10098498-9	1999	Western blots demonstrated expression of PKCalpha, betaI, epsilon, delta, and zeta in H9c2 cells; PKC inhibitors (staurosporine or Ro 31-8220) or down-regulation of PKCalpha, betaI, epsilon, and delta by long-term (24 h) TPA treatment caused a partial blockade of the AVP-induced response, whereas the A23187-induced AA release was unaffected by down-regulation of these isoforms.	Tetradecanoylphorbol Acetate	221-224	protein kinase C, alpha	Rattus norvegicus	41-82
10098498-9	1999	Western blots demonstrated expression of PKCalpha, betaI, epsilon, delta, and zeta in H9c2 cells; PKC inhibitors (staurosporine or Ro 31-8220) or down-regulation of PKCalpha, betaI, epsilon, and delta by long-term (24 h) TPA treatment caused a partial blockade of the AVP-induced response, whereas the A23187-induced AA release was unaffected by down-regulation of these isoforms.	Tetradecanoylphorbol Acetate	221-224	protein kinase C, alpha	Rattus norvegicus	41-44
10098498-9	1999	Western blots demonstrated expression of PKCalpha, betaI, epsilon, delta, and zeta in H9c2 cells; PKC inhibitors (staurosporine or Ro 31-8220) or down-regulation of PKCalpha, betaI, epsilon, and delta by long-term (24 h) TPA treatment caused a partial blockade of the AVP-induced response, whereas the A23187-induced AA release was unaffected by down-regulation of these isoforms.	Tetradecanoylphorbol Acetate	221-224	protein kinase C, alpha	Rattus norvegicus	165-200
10098498-12	1999	AVP- or TPA-induced activation and tyrosine phosphorylation of p42 MAPK were completely blocked by down-regulation of PKCalpha, betaI, epsilon, and delta, but still occurred, together with the cytosolic PLA2 mobility shift, in the absence of external Ca2+.	Tetradecanoylphorbol Acetate	8-11	protein kinase C, alpha	Rattus norvegicus	118-153
10460009-7	1999	Furthermore, this c-fos expression is not inhibited by cycloheximide, but is completely abolished by pretreatment with TPA, so that the c-fos gene is a direct target of TGF-beta1 signalling and PKC is involved in this c-fos induction.	Tetradecanoylphorbol Acetate	119-122	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	18-23
10460009-7	1999	Furthermore, this c-fos expression is not inhibited by cycloheximide, but is completely abolished by pretreatment with TPA, so that the c-fos gene is a direct target of TGF-beta1 signalling and PKC is involved in this c-fos induction.	Tetradecanoylphorbol Acetate	119-122	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	136-141
10460009-7	1999	Furthermore, this c-fos expression is not inhibited by cycloheximide, but is completely abolished by pretreatment with TPA, so that the c-fos gene is a direct target of TGF-beta1 signalling and PKC is involved in this c-fos induction.	Tetradecanoylphorbol Acetate	119-122	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	136-141
10460017-3	1999	It is interesting that TPA induced 24-hydroxylation activity far more efficiently than dbcAMP, in addition to their effects in increasing VDR.	Tetradecanoylphorbol Acetate	23-26	vitamin D receptor	Homo sapiens	138-141
10460017-4	1999	TPA increased basal levels of c-fos mRNA to the maximum by 1 h after the treatment, whereas dbcAMP failed to affect c-fos gene expression.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-35
10460017-5	1999	Together with the previous data indicating the presence of AP-1-like sequence in the promoter of 24-hydroxylase gene, it was suggested that TPA potentiated the effect of 1,25-(OH)2D3 through an activation of c-fos gene expression.	Tetradecanoylphorbol Acetate	140-143	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	208-213
10460017-6	1999	This notion was further supported by the data showing that TPA and dbcAMP also acted in a synergistic manner to activate c-fos gene expression.	Tetradecanoylphorbol Acetate	59-62	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	121-126
10363574-7	1999	Ornithine decarboxylase (ODC) activity following topical application of phytol was increased in a dose-dependent manner and showed a weak, delayed induction (which was maximal 11-12 h after treatment) as compared with the case of TPA.	Tetradecanoylphorbol Acetate	230-233	ornithine decarboxylase, structural 1	Mus musculus	25-28
10326864-3	1999	A single treatment with three different tumor promoters (12-O-tetradecanoylphorbol-13-acetate (TPA), anthralin, and thapsigargin) induced IL-1Ra mRNA with different kinetics in mouse skin.	Tetradecanoylphorbol Acetate	57-93	interleukin 1 receptor antagonist	Mus musculus	138-144
10326864-3	1999	A single treatment with three different tumor promoters (12-O-tetradecanoylphorbol-13-acetate (TPA), anthralin, and thapsigargin) induced IL-1Ra mRNA with different kinetics in mouse skin.	Tetradecanoylphorbol Acetate	95-98	interleukin 1 receptor antagonist	Mus musculus	138-144
10326864-4	1999	The expression of IL-1Ra mRNA also was induced by TPA and IL-1alpha in a dose-related and time-dependent manner in cultured mouse keratinocytes.	Tetradecanoylphorbol Acetate	50-53	interleukin 1 receptor antagonist	Mus musculus	18-24
10085148-3	1999	Treatment of neonatal cardiac myocytes with the hypertrophic agonist 12-O-tetradecanoylphorbol-13-acetate or phenylephrine increased expression of Glut1 mRNA relative to Glut4 mRNA.	Tetradecanoylphorbol Acetate	69-105	solute carrier family 2 member 1	Homo sapiens	147-152
10085148-5	1999	Stimulation of the cells with 12-O-tetradecanoylphorbol-13-acetate or phenylephrine induced transcription from the Glut1 promoter, which was inhibited by cotransfection with the mitogen-activated protein kinase phosphatases CL100 and MKP-3.	Tetradecanoylphorbol Acetate	30-66	solute carrier family 2 member 1	Homo sapiens	115-120
10037704-9	1999	C/EBPbeta and C/EBPdelta inhibit both TPA- and C/EBPalpha-dependent promoter activation, indicating functional differences among C/EBP family members.	Tetradecanoylphorbol Acetate	38-41	CCAAT enhancer binding protein delta	Homo sapiens	14-24
10228559-6	1999	TPA stimulation of A2780/CP70 cells also resulted in a rapid but transient induction of c-jun and c-fos as determined by Northern and Western blot analyses, which peaked about 2 h before the peak in ERCC-1 expression.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	88-93
10228559-6	1999	TPA stimulation of A2780/CP70 cells also resulted in a rapid but transient induction of c-jun and c-fos as determined by Northern and Western blot analyses, which peaked about 2 h before the peak in ERCC-1 expression.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-103
10228559-11	1999	These data suggest that AP-1 may contribute to the upregulation of ERCC-1 in response to TPA in human ovarian cancer cells.	Tetradecanoylphorbol Acetate	89-92	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	24-28
10094489-10	1999	The PKC isoform most translocated by TPA was PKC-delta.	Tetradecanoylphorbol Acetate	37-40	protein kinase C, alpha	Rattus norvegicus	4-7
9988737-10	1999	The expression of this mutant form of c-Jun also completely blocks 12-O-tetradecanoylphorbol-13-acetate-induced M-CSF receptor promoter activity during monocytic differentiation.	Tetradecanoylphorbol Acetate	67-103	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-43
10211940-0	1999	Inhibitory effect of munetone, an isoflavonoid, on 12-O-tetradecanoylphorbol 13-acetate-induced ornithine decarboxylase activity.	Tetradecanoylphorbol Acetate	51-87	ornithine decarboxylase, structural 1	Mus musculus	96-119
10211940-2	1999	(Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified as an active principle (IC50 = 46 ng/ml).	Tetradecanoylphorbol Acetate	59-95	ornithine decarboxylase, structural 1	Mus musculus	110-133
10211940-2	1999	(Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified as an active principle (IC50 = 46 ng/ml).	Tetradecanoylphorbol Acetate	59-95	ornithine decarboxylase, structural 1	Mus musculus	144-147
10211940-2	1999	(Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified as an active principle (IC50 = 46 ng/ml).	Tetradecanoylphorbol Acetate	97-100	ornithine decarboxylase, structural 1	Mus musculus	110-133
10211940-2	1999	(Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified as an active principle (IC50 = 46 ng/ml).	Tetradecanoylphorbol Acetate	97-100	ornithine decarboxylase, structural 1	Mus musculus	144-147
10211940-4	1999	In addition, munetone inhibited TPA-independent c-Myc-induced ODC activity with cultured BALB/c c-MycER cells, as well as 7,12-dimethylbenz[a]anthracene (DMBA)-induced preneoplastic lesion formation in a mouse mammary gland organ culture (MMOC) system.	Tetradecanoylphorbol Acetate	32-35	ornithine decarboxylase, structural 1	Mus musculus	62-65
9920928-2	1999	The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation.	Tetradecanoylphorbol Acetate	67-98	intercellular adhesion molecule 1	Homo sapiens	276-282
9920928-2	1999	The lower classic PKC activity on pretreatment with phorbol ester (phorbol 12-myristate 13-acetate (PMA)) for 24 h markedly decreased IL-1beta-induced E-selectin mRNA expression in the presence of fetal calf serum and basic fibroblast growth factor, although the induction of ICAM-1 mRNA expression was only influenced a little by the PKC down-regulation.	Tetradecanoylphorbol Acetate	100-103	intercellular adhesion molecule 1	Homo sapiens	276-282
9973380-5	1999	Freshly isolated CRTH2+ CD4+ T cells produced Th2- but little or no Th1-type cytokines upon stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	109-112	prostaglandin D2 receptor 2	Homo sapiens	17-22
9891065-8	1999	TPA-induced activation of the SRE was partially inhibited by dominant negative c-Raf, ERK1, or ERK2, and constitutively active mutants of PKC-alpha and PKC-epsilon activated the transactivation domain of Elk-1.	Tetradecanoylphorbol Acetate	0-3	v-raf-leukemia viral oncogene 1	Mus musculus	79-84
9891065-10	1999	Furthermore, TPA treatment of serum-starved NIH 3T3 cells led to phosphorylation of SEK1, and constitutively active mutants of PKC-alpha and PKC-epsilon activated the transactivation domain of c-Jun, a major substrate of JNK.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 8	Mus musculus	221-224
10068151-5	1999	The stimulatory effect of phorbol 12-myristate 13-acetate (PMA) (0.1 microg/ml) on superoxide production and myeloperoxidase, which is inhibited by 100 nM staurosporine, was not affected by 100 microM ambroxol.	Tetradecanoylphorbol Acetate	26-57	myeloperoxidase	Mus musculus	109-124
10068151-5	1999	The stimulatory effect of phorbol 12-myristate 13-acetate (PMA) (0.1 microg/ml) on superoxide production and myeloperoxidase, which is inhibited by 100 nM staurosporine, was not affected by 100 microM ambroxol.	Tetradecanoylphorbol Acetate	59-62	myeloperoxidase	Mus musculus	109-124
10195695-3	1999	Our results demonstrate that induction of differentiation in NHEK by either treatment with the phorbol ester phorbol 12-myristate-13-acetate (PMA), suspension culture or confluence greatly enhances the expression of PPARbeta mRNA.	Tetradecanoylphorbol Acetate	109-140	peroxisome proliferator activated receptor delta	Homo sapiens	216-224
10195695-3	1999	Our results demonstrate that induction of differentiation in NHEK by either treatment with the phorbol ester phorbol 12-myristate-13-acetate (PMA), suspension culture or confluence greatly enhances the expression of PPARbeta mRNA.	Tetradecanoylphorbol Acetate	142-145	peroxisome proliferator activated receptor delta	Homo sapiens	216-224
9932728-2	1999	We found that activity and mobility on electrophoresis gels of the cPLA2 protein were significantly increased by f-Met-Leu-Phe (fMLP), 12-myristate 13-acetate (PMA) and the Ca2+-ATPase inhibitors, thapsigargin and cyclopiazonic acid.	Tetradecanoylphorbol Acetate	160-163	phospholipase A2 group IVA	Homo sapiens	67-72
9989263-3	1999	Upon treatment with phorbol myristate acetate (PMA), PKC alpha translocated from the cytosolic fraction to the membrane fraction to which PLD1 also localized.	Tetradecanoylphorbol Acetate	20-45	protein kinase C, alpha	Rattus norvegicus	53-62
9989263-3	1999	Upon treatment with phorbol myristate acetate (PMA), PKC alpha translocated from the cytosolic fraction to the membrane fraction to which PLD1 also localized.	Tetradecanoylphorbol Acetate	47-50	protein kinase C, alpha	Rattus norvegicus	53-62
9989263-5	1999	However, most of GFP-PKC alpha was translocated from the cytosol to the plasma membrane after treatment with PMA.	Tetradecanoylphorbol Acetate	109-112	protein kinase C, alpha	Rattus norvegicus	21-30
10851292-12	1999	Moreover, because both prolactin and TPA induced PKC activity, and because the effects of prolactin and TPA were eliminated when PKC was downregulated, we postulate that the prolactin effect on mAAT expression is mediated via the diacylglycerol PKC signal transduction pathway in rat lateral prostate and human prostate cancer cells.	Tetradecanoylphorbol Acetate	37-40	protein kinase C, gamma	Rattus norvegicus	49-52
10851292-12	1999	Moreover, because both prolactin and TPA induced PKC activity, and because the effects of prolactin and TPA were eliminated when PKC was downregulated, we postulate that the prolactin effect on mAAT expression is mediated via the diacylglycerol PKC signal transduction pathway in rat lateral prostate and human prostate cancer cells.	Tetradecanoylphorbol Acetate	104-107	protein kinase C, gamma	Rattus norvegicus	129-132
10851292-12	1999	Moreover, because both prolactin and TPA induced PKC activity, and because the effects of prolactin and TPA were eliminated when PKC was downregulated, we postulate that the prolactin effect on mAAT expression is mediated via the diacylglycerol PKC signal transduction pathway in rat lateral prostate and human prostate cancer cells.	Tetradecanoylphorbol Acetate	104-107	protein kinase C, gamma	Rattus norvegicus	129-132
10578486-4	1999	Topical application of baicalein inhibited tumor promoter-caused induction of epidermal ornithine decarboxylase activity by TPA (5 nmol).	Tetradecanoylphorbol Acetate	124-127	ornithine decarboxylase, structural 1	Mus musculus	88-111
10578486-6	1999	Pretreatment of mouse skin with various amounts of baicalein caused inhibition of H2O2 and myeloperoxidase formation by TPA.	Tetradecanoylphorbol Acetate	120-123	myeloperoxidase	Mus musculus	82-106
9862370-3	1998	Addition of various co-stimuli (phorbol 12-myristate 13-acetate or monoclonal antibodies to CD3 or CD2) increases the CD82-induced morphological alterations and, reciprocally, CD82 engagement synergizes with these stimuli to induce T cell activation as indicated by both primary tyrosine phosphorylation and IL-2 production.	Tetradecanoylphorbol Acetate	32-63	CD82 molecule	Homo sapiens	118-122
9862370-3	1998	Addition of various co-stimuli (phorbol 12-myristate 13-acetate or monoclonal antibodies to CD3 or CD2) increases the CD82-induced morphological alterations and, reciprocally, CD82 engagement synergizes with these stimuli to induce T cell activation as indicated by both primary tyrosine phosphorylation and IL-2 production.	Tetradecanoylphorbol Acetate	32-63	CD82 molecule	Homo sapiens	176-180
9887232-11	1998	The cytosolic PLA2 (cPLA2)/Ca2+-independent PLA2 (iPLA2) inhibitor, AACOCF3, inhibited 75.6% PMA-stimulated LPA secretion in ovarian cancer cells, suggesting a cPLA2/iPLA2 activity was involved in LPA production from ovarian cancer cells.	Tetradecanoylphorbol Acetate	93-96	phospholipase A2 group IVA	Homo sapiens	4-18
9887232-11	1998	The cytosolic PLA2 (cPLA2)/Ca2+-independent PLA2 (iPLA2) inhibitor, AACOCF3, inhibited 75.6% PMA-stimulated LPA secretion in ovarian cancer cells, suggesting a cPLA2/iPLA2 activity was involved in LPA production from ovarian cancer cells.	Tetradecanoylphorbol Acetate	93-96	phospholipase A2 group IVA	Homo sapiens	20-25
9885906-10	1998	Similar cytokine profiles were obtained when the CD4+ T cells were stimulated by Leishmania major-antigen instead of PMA/ionomycin.	Tetradecanoylphorbol Acetate	117-120	CD4 antigen	Mus musculus	49-52
9847438-5	1998	For this purpose, human lymphocytes were induced to express IL-4Ralpha chain by means of protein kinase C (PKC) activation with phorbol myristate acetate (PMA) or by triggering the Janus kinase-Stat pathway with IL-4 in the presence or absence of pharmacologic doses of dexamethasone.	Tetradecanoylphorbol Acetate	128-153	interleukin 4 receptor	Homo sapiens	60-70
9847438-5	1998	For this purpose, human lymphocytes were induced to express IL-4Ralpha chain by means of protein kinase C (PKC) activation with phorbol myristate acetate (PMA) or by triggering the Janus kinase-Stat pathway with IL-4 in the presence or absence of pharmacologic doses of dexamethasone.	Tetradecanoylphorbol Acetate	155-158	interleukin 4 receptor	Homo sapiens	60-70
10723128-7	2000	We find here that the FAP1 site contributes strongly to phorbol ester (TPA) and Erk MAP kinase activation of the c-fos enhancer and that both the p62TCF and FAP1 sites are required for effective activation of the enhancer.	Tetradecanoylphorbol Acetate	71-74	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-118
10723128-8	2000	We further find that the FAP1 site binds ATF1 and CREB from HeLa nuclear extracts and that the phosphorylation of these factors is induced by TPA.	Tetradecanoylphorbol Acetate	142-145	cAMP responsive element binding protein 1	Homo sapiens	50-54
10702388-5	2000	Expression of vIRF1, vIL6, and PF-8 proteins in the infected B cells of MCD lymph nodes reproduces the expression pattern observed in TPA-stimulated KSHV-infected B-cell lines.	Tetradecanoylphorbol Acetate	134-137	K9	Human gammaherpesvirus 8	14-19
10688817-5	2000	The target for this inhibition was Jak2, and the activation of PKC by 12-O-tetradecanoyl-phorbol-13-acetate treatment also abrogated IL-3-induced tyrosine phosphorylation of Jak2 in Ba/F3 cells.	Tetradecanoylphorbol Acetate	70-107	protein kinase C, delta	Mus musculus	63-66
10679127-6	2000	Interestingly, synovial fluid cells, in contrast to PBMCs isolated from patients with rheumatoid arthritis, but not osteoarthritis, respond to PMA + ionomycin with much lower, comparable to IL-15-triggered IL-17 secretion.	Tetradecanoylphorbol Acetate	143-146	interleukin 17A	Homo sapiens	206-211
10679127-7	2000	Moreover, PMA + ionomycin-triggered IL-17 secretion is completely or partially blocked in the presence of low doses of cyclosporin A or high doses of methylprednisolone, respectively.	Tetradecanoylphorbol Acetate	10-13	interleukin 17A	Homo sapiens	36-41
10693946-3	2000	Significant increases in the levels of c-fos, c-jun, and egr-1 but not NGFIB mRNA were observed in PC12 cells exposed to lead or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	129-160	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	39-44
10739005-8	2000	In the case of the monocytic maturation of HL-60 cells treated with phorbol esters (PMA), the abl and bcr homologous genes were repositioned closer to each other and closer to the nuclear centre.	Tetradecanoylphorbol Acetate	84-87	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	94-97
10688643-2	2000	We found that the phorbol myristate acetate (PMA)-responsive protein kinase C (PKC) isotypes (alpha, betaI, betaII, and delta) or phosphatidylinositol-3-OH kinase (PI 3-kinase) itself activated LFA-1 to bind ICAM-1.	Tetradecanoylphorbol Acetate	18-43	intercellular adhesion molecule 1	Homo sapiens	208-214
10688643-2	2000	We found that the phorbol myristate acetate (PMA)-responsive protein kinase C (PKC) isotypes (alpha, betaI, betaII, and delta) or phosphatidylinositol-3-OH kinase (PI 3-kinase) itself activated LFA-1 to bind ICAM-1.	Tetradecanoylphorbol Acetate	45-48	intercellular adhesion molecule 1	Homo sapiens	208-214
10769627-3	2000	Exposure to the protein kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H7), increased the phosphorylation of wild type p53 protein, whereas exposure to the tumor promoter phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), decreased it in vivo following 3 hours incubation with mouse epidermal JB6 cells.	Tetradecanoylphorbol Acetate	220-257	mitogen-activated protein kinase kinase kinase 14	Mus musculus	16-30
10769627-3	2000	Exposure to the protein kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H7), increased the phosphorylation of wild type p53 protein, whereas exposure to the tumor promoter phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), decreased it in vivo following 3 hours incubation with mouse epidermal JB6 cells.	Tetradecanoylphorbol Acetate	259-262	mitogen-activated protein kinase kinase kinase 14	Mus musculus	16-30
10714394-2	2000	In an attempt to reveal the mechanism of tumor cell CD44 activation, we compared the physical and chemical properties of CD44 in nonactivated LB cell lymphoma with those in phorbol 12-myristate 13-acetate (PMA)-activated LB cells and of an LB cell subline (designated HA9) expressing constitutively-active CD44.	Tetradecanoylphorbol Acetate	206-209	CD44 molecule (Indian blood group)	Homo sapiens	52-56
10714394-8	2000	Similarly, under suboptimal conditions, a synergistic effect was obtained with tunicamycin and PMA: each one alone was ineffective but in combination they induced the acquisition of HA binding by the lymphoma cells, while their CD44 expression was not enhanced.	Tetradecanoylphorbol Acetate	95-98	CD44 molecule (Indian blood group)	Homo sapiens	228-232
11023645-6	2000	However, tumor promoter phorbol ester 12-o-tetradecanoyl phorbol-13-acetate (TPA) functioned as a potent inhibitor of both PAcP and PSA expression.	Tetradecanoylphorbol Acetate	38-75	acid phosphatase 3	Homo sapiens	123-127
11023645-6	2000	However, tumor promoter phorbol ester 12-o-tetradecanoyl phorbol-13-acetate (TPA) functioned as a potent inhibitor of both PAcP and PSA expression.	Tetradecanoylphorbol Acetate	77-80	acid phosphatase 3	Homo sapiens	123-127
11023645-7	2000	Prolonged treatment with DHT as well as TPA resulted in a similar down-regulation of protein kinase C and cellular PAcP activities.	Tetradecanoylphorbol Acetate	40-43	acid phosphatase 3	Homo sapiens	115-119
11093031-2	2000	The down-regulation of PKCalpha by long-term exposure to phorbol myristate acetate (PMA) provoked a reduced mitogenic response to EGF while the down-regulation of PKCepsilon with oligonucleotide antisense had no effect on the stimulation of DNA synthesis, assayed as thymidine incorporation.	Tetradecanoylphorbol Acetate	57-82	epidermal growth factor	Gallus gallus	130-133
11093031-2	2000	The down-regulation of PKCalpha by long-term exposure to phorbol myristate acetate (PMA) provoked a reduced mitogenic response to EGF while the down-regulation of PKCepsilon with oligonucleotide antisense had no effect on the stimulation of DNA synthesis, assayed as thymidine incorporation.	Tetradecanoylphorbol Acetate	84-87	epidermal growth factor	Gallus gallus	130-133
11315098-4	2000	In addition, conditioned medium collected from SNB19 cells transfected with these expression vectors showed diminished MMP-9 activity in the presence of phorbol myristate acetate, as determined by gelatin zymography.	Tetradecanoylphorbol Acetate	153-178	matrix metallopeptidase 9	Homo sapiens	119-124
10655565-6	2000	Other known stimuli for NK cells (IL-2 and CD16 monoclonal antibody and incubation with K562, the NK-sensitive cell line) promoted IFN-gamma and TNF-alpha production in NK cells to a lesser extent than did PMA and ionomycin stimulation.	Tetradecanoylphorbol Acetate	206-209	Fc gamma receptor IIIa	Homo sapiens	43-47
10634419-7	2000	RANTES production was increased by phorbol 12-myristate 13-acetate, but not by 8-bromo-cAMP.	Tetradecanoylphorbol Acetate	35-66	C-C motif chemokine ligand 5	Homo sapiens	0-6
10590133-4	2000	Northern blot analysis showed that K15 was weakly expressed in latently infected BCBL-1 cells, and the level of its expression was significantly induced by tetradecanoyl phorbol acetate stimulation.	Tetradecanoylphorbol Acetate	156-185	keratin 15	Homo sapiens	35-38
10601280-6	1999	The first one is a TPA-responsive element that controls the base-line ST3 promoter activity but is not required for its activation.	Tetradecanoylphorbol Acetate	19-22	matrix metallopeptidase 11	Homo sapiens	70-73
10601319-7	1999	TPA treatment rapidly induced phosphorylation of the CREB-1/ATF-1-like factor via the protein kinase C pathway.	Tetradecanoylphorbol Acetate	0-3	cAMP responsive element binding protein 1	Homo sapiens	53-59
10601319-8	1999	These results led us to conclude that the human MnSOD gene having the promoter construct used in this study is induced by TPA via activation of a CREB-1/ATF-1-like factor and not via either NF-kappaB or AP-1.	Tetradecanoylphorbol Acetate	122-125	cAMP responsive element binding protein 1	Homo sapiens	146-152
10637505-5	1999	Analysis of cells stably expressing Elk-1 in vivo shows that following serum or TPA stimulation, residues T353, T363, T368, S383, S389 and T417 become phosphorylated with similar kinetics.	Tetradecanoylphorbol Acetate	80-83	ETS transcription factor ELK1	Homo sapiens	36-41
10673028-4	1999	Gel supershift assays were performed to detect association of all seven AP-1 family members with their DNA binding site in TPA-treated and -untreated P+ and P- cells.	Tetradecanoylphorbol Acetate	123-126	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-76
10673032-7	1999	The promoter region contains functional serum response element, YY1-like binding site and AP1 site, which is supported by the finding that the expression of RACK1 gene in cultured porcine ST cells has a serum response as well as a TPA response.	Tetradecanoylphorbol Acetate	231-234	receptor for activated C kinase 1	Homo sapiens	157-162
10572244-5	1999	A total of 10 nM 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of PKC, induced the accumulation of HSP27.	Tetradecanoylphorbol Acetate	17-53	heat shock protein 1	Mus musculus	110-115
10572244-5	1999	A total of 10 nM 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of PKC, induced the accumulation of HSP27.	Tetradecanoylphorbol Acetate	55-58	heat shock protein 1	Mus musculus	110-115
10583731-5	1999	CRF-BP mRNA levels were determined by Northern analysis following 12 h treatment with the following agents: forskolin (1-30 microM), CRF (1-1000 nM), phorbol-12-myristate-13-acetate (TPA; 1-50 nM), dexamethasone (1-100 nM) and IL6 (10-500 pM).	Tetradecanoylphorbol Acetate	150-181	corticotropin releasing hormone binding protein	Rattus norvegicus	0-6
10583731-5	1999	CRF-BP mRNA levels were determined by Northern analysis following 12 h treatment with the following agents: forskolin (1-30 microM), CRF (1-1000 nM), phorbol-12-myristate-13-acetate (TPA; 1-50 nM), dexamethasone (1-100 nM) and IL6 (10-500 pM).	Tetradecanoylphorbol Acetate	183-186	corticotropin releasing hormone binding protein	Rattus norvegicus	0-6
10583731-6	1999	Significant increases in CRF-BP mRNA were observed in response to forskolin (30 mM), CRF (100, 1000 nM), IL6 (100, 500 pM), TPA (50 nM) and dexamethasone (100 nM; P&lt;0.05 for all; n=3-6 for all).	Tetradecanoylphorbol Acetate	124-127	corticotropin releasing hormone binding protein	Rattus norvegicus	25-31
10583731-8	1999	Twenty-four hour treatment with 30 microM forskolin, 1000 nM CRF, 50 nM TPA, 100 pM IL6 or 100 nM dexamethasone significantly increased CRF-BP expression (P&lt;0.05, n=3 for each treatment).	Tetradecanoylphorbol Acetate	72-75	corticotropin releasing hormone binding protein	Rattus norvegicus	136-142
10569807-3	1999	To determine the sensitivity to a chemical promotion stimulus, HK1.fos/alpha mice were promoted with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	101-137	hexokinase 1	Mus musculus	63-66
10569807-3	1999	To determine the sensitivity to a chemical promotion stimulus, HK1.fos/alpha mice were promoted with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	139-142	hexokinase 1	Mus musculus	63-66
10569807-4	1999	Previously, after 7 mo TPA promotion of HK1.TGFalpha mice that express moderate levels of TGFalpha elicited papillomas that remained regression-prone and benign for up to 2 yr.	Tetradecanoylphorbol Acetate	23-26	hexokinase 1	Mus musculus	40-52
10569807-5	1999	In HK1.fos mice, 6 mo TPA elicited papillomas that required spontaneous c-Ha-ras activation and converted to malignancy after 14-16 mo.	Tetradecanoylphorbol Acetate	22-25	hexokinase 1	Mus musculus	3-6
10569807-6	1999	We now show that in HK1.fos/alpha transgenic genotypes, TPA promotion accelerated papillomatogenesis, with the earliest papilloma appearance at 2 mo after initiation of TPA promotion.	Tetradecanoylphorbol Acetate	56-59	hexokinase 1	Mus musculus	20-23
10582689-5	1999	Despite this mild phenotype, the effects of PKCdelta overexpression on mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) were dramatic.	Tetradecanoylphorbol Acetate	101-137	protein kinase C, delta	Mus musculus	44-52
10582689-5	1999	Despite this mild phenotype, the effects of PKCdelta overexpression on mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) were dramatic.	Tetradecanoylphorbol Acetate	139-142	protein kinase C, delta	Mus musculus	44-52
10582689-14	1999	Thus, PKCdelta when expressed at sufficient levels can suppress skin tumor promotion by TPA.	Tetradecanoylphorbol Acetate	88-91	protein kinase C, delta	Mus musculus	6-14
10551813-6	1999	However, down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PKC inhibitor Ro-31-8220 did not block the activation of p70(S6k) by ROS, indicating that the activation of TPA-responsive PKC was not required for stimulation of p70(S6k) activity by H(2)O(2) in JB6 cells.	Tetradecanoylphorbol Acetate	66-69	annexin A6	Homo sapiens	209-212
10551813-6	1999	However, down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PKC inhibitor Ro-31-8220 did not block the activation of p70(S6k) by ROS, indicating that the activation of TPA-responsive PKC was not required for stimulation of p70(S6k) activity by H(2)O(2) in JB6 cells.	Tetradecanoylphorbol Acetate	66-69	annexin A6	Homo sapiens	315-318
10551813-6	1999	However, down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PKC inhibitor Ro-31-8220 did not block the activation of p70(S6k) by ROS, indicating that the activation of TPA-responsive PKC was not required for stimulation of p70(S6k) activity by H(2)O(2) in JB6 cells.	Tetradecanoylphorbol Acetate	134-137	annexin A6	Homo sapiens	209-212
10551813-6	1999	However, down-regulation of 12-O-tetradecanoylphorbol-13-acetate (TPA)-responsive protein kinase C (PKC) by chronic pretreatment with TPA or a specific PKC inhibitor Ro-31-8220 did not block the activation of p70(S6k) by ROS, indicating that the activation of TPA-responsive PKC was not required for stimulation of p70(S6k) activity by H(2)O(2) in JB6 cells.	Tetradecanoylphorbol Acetate	134-137	annexin A6	Homo sapiens	315-318
10555965-4	1999	While basal and PMA-stimulated phosphorylation were unaffected by the A(2A)AR-selective antagonist ZM241385, they were both blocked by GF109203X (a selective inhibitor of conventional and novel PKC isoforms) and rottlerin (a PKCdelta-selective inhibitor) but not Go6976 (selective for conventional PKC isoforms).	Tetradecanoylphorbol Acetate	16-19	protein kinase C, gamma	Rattus norvegicus	194-197
10555965-4	1999	While basal and PMA-stimulated phosphorylation were unaffected by the A(2A)AR-selective antagonist ZM241385, they were both blocked by GF109203X (a selective inhibitor of conventional and novel PKC isoforms) and rottlerin (a PKCdelta-selective inhibitor) but not Go6976 (selective for conventional PKC isoforms).	Tetradecanoylphorbol Acetate	16-19	protein kinase C, gamma	Rattus norvegicus	225-228
10555965-5	1999	However, coexpression of the A(2A)AR with each of the alpha, betaI, and betaII isoforms of PKC increased basal and PMA-stimulated phosphorylation.	Tetradecanoylphorbol Acetate	115-118	protein kinase C, gamma	Rattus norvegicus	91-94
10542109-4	1999	Further, we demonstrate that gastrin-releasing peptide, which activates a Gq-coupled GRP receptor, isoproterenol, which activates a Gs-coupled beta-adrenergic receptor, calcium ionophores, and phorbol 12-myristate 13-acetate, a stimulator of protein kinase C, can mediate increases in luciferase expression in the presence of forskolin but not in its absence.	Tetradecanoylphorbol Acetate	193-224	gastrin releasing peptide	Homo sapiens	29-54
10583213-5	1999	About 40% of platelet Sph-1-P could be released extracellularly by 12-O-tetradecanoylphorbol 13-acetate, possibly through mediation by protein kinase C. On the other hand, in erythrocytes, neutrophils and mononuclear cells a significant percentage of Sph-1-P formed inside the cell was discharged without stimulation, whereas the stimulation-dependent release was marginal.	Tetradecanoylphorbol Acetate	67-103	ankyrin 1	Homo sapiens	22-27
10607425-5	1999	Cyclosporin A inhibits induction of JNK function by TCR/CD28, PMA/ionomycin, ceramide, or H(2)O(2), but not induction by UV light or hyperosmolar sorbitol.	Tetradecanoylphorbol Acetate	62-65	mitogen-activated protein kinase 8	Mus musculus	36-39
10540182-8	1999	LS-180 cells spontaneously released hTM5 as well as CEP into the culture medium that was significantly stimulated by a calcium ionophore, A23187, but inhibited by phorbol-12-myristate-13-acetate, monensin and methylamine.	Tetradecanoylphorbol Acetate	163-194	tropomyosin 3	Homo sapiens	36-40
10630630-2	1999	The production of CFI by Hep G2 cells was enhanced in a dose- and time-dependent fashion by 12-O-tetradecanoyl-1,2-phorbol 13-acetate (TPA), a potent PKC activator.	Tetradecanoylphorbol Acetate	135-138	complement factor I	Homo sapiens	18-21
10630630-4	1999	The TPA-dependent increase in CFI secretion was correlated with an increase in CFI mRNA levels.	Tetradecanoylphorbol Acetate	4-7	complement factor I	Homo sapiens	30-33
10630630-4	1999	The TPA-dependent increase in CFI secretion was correlated with an increase in CFI mRNA levels.	Tetradecanoylphorbol Acetate	4-7	complement factor I	Homo sapiens	79-82
10630630-7	1999	However, calphostin C, a specific inhibitor of PKC, abolished the TPA-induced increase in CFI mRNA levels.	Tetradecanoylphorbol Acetate	66-69	complement factor I	Homo sapiens	90-93
10630630-8	1999	Down regulation of intracellular PKC levels by prior exposure of Hep G2 cells to a high concentration of TPA also blocked the increase in CFI mRNA levels induced by TPA suggesting that the TPA effects were mediated via activation of PKC.	Tetradecanoylphorbol Acetate	105-108	complement factor I	Homo sapiens	138-141
10630630-8	1999	Down regulation of intracellular PKC levels by prior exposure of Hep G2 cells to a high concentration of TPA also blocked the increase in CFI mRNA levels induced by TPA suggesting that the TPA effects were mediated via activation of PKC.	Tetradecanoylphorbol Acetate	165-168	complement factor I	Homo sapiens	138-141
10630630-8	1999	Down regulation of intracellular PKC levels by prior exposure of Hep G2 cells to a high concentration of TPA also blocked the increase in CFI mRNA levels induced by TPA suggesting that the TPA effects were mediated via activation of PKC.	Tetradecanoylphorbol Acetate	165-168	complement factor I	Homo sapiens	138-141
10630630-9	1999	mRNA decay studies indicated that the half-life of CFI mRNA in TPA-induced cells was not significantly different from control.	Tetradecanoylphorbol Acetate	63-66	complement factor I	Homo sapiens	51-54
10630630-10	1999	Nuclear run-on transcriptional assays on the other hand demonstrated that whereas the CFI gene is transcribed under basal conditions in Hep G2 cells, TPA induced a 3-4 fold increase in the transcription rate of CFI gene in 24 h. The transcription rate of GAPDH gene did not change, indicating that the effects were not general on gene transcription.	Tetradecanoylphorbol Acetate	150-153	complement factor I	Homo sapiens	211-214
10630630-14	1999	These results indicate that TPA regulation of CFI gene requires PKC signalling and is mediated by via a TPA response element (TRE) in the CFI promoter region located at -136/-130 and involves the transactivation of AP-1 and NF-kappaB transcription factors.	Tetradecanoylphorbol Acetate	28-31	complement factor I	Homo sapiens	46-49
10630630-14	1999	These results indicate that TPA regulation of CFI gene requires PKC signalling and is mediated by via a TPA response element (TRE) in the CFI promoter region located at -136/-130 and involves the transactivation of AP-1 and NF-kappaB transcription factors.	Tetradecanoylphorbol Acetate	28-31	complement factor I	Homo sapiens	138-141
10630630-14	1999	These results indicate that TPA regulation of CFI gene requires PKC signalling and is mediated by via a TPA response element (TRE) in the CFI promoter region located at -136/-130 and involves the transactivation of AP-1 and NF-kappaB transcription factors.	Tetradecanoylphorbol Acetate	104-107	complement factor I	Homo sapiens	46-49
10630630-14	1999	These results indicate that TPA regulation of CFI gene requires PKC signalling and is mediated by via a TPA response element (TRE) in the CFI promoter region located at -136/-130 and involves the transactivation of AP-1 and NF-kappaB transcription factors.	Tetradecanoylphorbol Acetate	104-107	complement factor I	Homo sapiens	138-141
10521508-5	1999	In both COS-1 and HEK-293 cells transiently overexpressing CXCR4, SDF-1alpha and phorbol esters (PMA) promoted rapid internalization of cell surface receptors as assessed by both enzyme-linked immunosorbent assay and immunofluorescence analysis.	Tetradecanoylphorbol Acetate	97-100	C-X-C motif chemokine receptor 4	Homo sapiens	59-64
10512355-5	1999	We identified and determined the glucose transporters and PKC isoforms affected by insulin and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	95-131	protein kinase C, alpha	Rattus norvegicus	58-61
10512355-5	1999	We identified and determined the glucose transporters and PKC isoforms affected by insulin and 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	133-136	protein kinase C, alpha	Rattus norvegicus	58-61
10512355-8	1999	In contrast, TPA translocated GLUT1 and GLUT3 without affecting GLUT4.	Tetradecanoylphorbol Acetate	13-16	solute carrier family 2 member 3	Rattus norvegicus	40-45
10512355-10	1999	TPA translocated and activated PKC-alpha, -beta2, and -delta; these effects were not noticeably affected by PI3K inhibitors.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	31-40
10564368-10	1999	Furthermore, pretreatment of the neurons with the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), attenuated the N/OFQ inhibition of the calcium channel current whereas the cAMP-dependent kinase A activator, forskolin, showed no effect, suggesting the probable involvement of PKC in the N/OFQ-induced desensitization.	Tetradecanoylphorbol Acetate	84-115	protein kinase C, gamma	Rattus norvegicus	50-66
10564368-10	1999	Furthermore, pretreatment of the neurons with the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), attenuated the N/OFQ inhibition of the calcium channel current whereas the cAMP-dependent kinase A activator, forskolin, showed no effect, suggesting the probable involvement of PKC in the N/OFQ-induced desensitization.	Tetradecanoylphorbol Acetate	84-115	protein kinase C, gamma	Rattus norvegicus	68-71
10504492-10	1999	Exposure of VSMCs to PMA for 3 hours mimicked the short-term effect of ALDO on NHE activity.	Tetradecanoylphorbol Acetate	21-24	solute carrier family 9 member A1	Rattus norvegicus	79-82
10464284-4	1999	To address the mechanisms regulating CD44 cleavage at the extracellular domain, we show that 12-O-tetradecanoylphorbol 13-acetate (TPA) and the calcium ionophore ionomycin rapidly enhance metalloprotease-mediated CD44 cleavage in U251MG cells via protein kinase C-dependent and -independent pathways, respectively, suggesting the existence of multiple distinct pathways for regulation of CD44 cleavage.	Tetradecanoylphorbol Acetate	93-129	CD44 molecule (Indian blood group)	Homo sapiens	37-41
10464284-4	1999	To address the mechanisms regulating CD44 cleavage at the extracellular domain, we show that 12-O-tetradecanoylphorbol 13-acetate (TPA) and the calcium ionophore ionomycin rapidly enhance metalloprotease-mediated CD44 cleavage in U251MG cells via protein kinase C-dependent and -independent pathways, respectively, suggesting the existence of multiple distinct pathways for regulation of CD44 cleavage.	Tetradecanoylphorbol Acetate	93-129	CD44 molecule (Indian blood group)	Homo sapiens	213-217
10464284-4	1999	To address the mechanisms regulating CD44 cleavage at the extracellular domain, we show that 12-O-tetradecanoylphorbol 13-acetate (TPA) and the calcium ionophore ionomycin rapidly enhance metalloprotease-mediated CD44 cleavage in U251MG cells via protein kinase C-dependent and -independent pathways, respectively, suggesting the existence of multiple distinct pathways for regulation of CD44 cleavage.	Tetradecanoylphorbol Acetate	93-129	CD44 molecule (Indian blood group)	Homo sapiens	213-217
10464284-4	1999	To address the mechanisms regulating CD44 cleavage at the extracellular domain, we show that 12-O-tetradecanoylphorbol 13-acetate (TPA) and the calcium ionophore ionomycin rapidly enhance metalloprotease-mediated CD44 cleavage in U251MG cells via protein kinase C-dependent and -independent pathways, respectively, suggesting the existence of multiple distinct pathways for regulation of CD44 cleavage.	Tetradecanoylphorbol Acetate	131-134	CD44 molecule (Indian blood group)	Homo sapiens	37-41
10464284-4	1999	To address the mechanisms regulating CD44 cleavage at the extracellular domain, we show that 12-O-tetradecanoylphorbol 13-acetate (TPA) and the calcium ionophore ionomycin rapidly enhance metalloprotease-mediated CD44 cleavage in U251MG cells via protein kinase C-dependent and -independent pathways, respectively, suggesting the existence of multiple distinct pathways for regulation of CD44 cleavage.	Tetradecanoylphorbol Acetate	131-134	CD44 molecule (Indian blood group)	Homo sapiens	213-217
10464284-4	1999	To address the mechanisms regulating CD44 cleavage at the extracellular domain, we show that 12-O-tetradecanoylphorbol 13-acetate (TPA) and the calcium ionophore ionomycin rapidly enhance metalloprotease-mediated CD44 cleavage in U251MG cells via protein kinase C-dependent and -independent pathways, respectively, suggesting the existence of multiple distinct pathways for regulation of CD44 cleavage.	Tetradecanoylphorbol Acetate	131-134	CD44 molecule (Indian blood group)	Homo sapiens	213-217
10469619-4	1999	Following tumor initiation with DMBA, topical application of GSP at doses of 0.5 and 1.5 mg/mouse/application to the dorsal initiated mouse skin resulted in a highly significant inhibition of TPA tumor promotion.	Tetradecanoylphorbol Acetate	192-195	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	61-64
10469622-0	1999	Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters.	Tetradecanoylphorbol Acetate	91-94	thioredoxin 1	Mus musculus	13-24
10469622-2	1999	The specific activity of thioredoxin and thioredoxin reductase in extracts from normal epidermis increased by 40 and 50%, respectively, after single or multiple application of TPA.	Tetradecanoylphorbol Acetate	176-179	thioredoxin 1	Mus musculus	25-36
10469622-7	1999	Multiple applications of TPA to tumor initiated (7,12-dimethyl[a]benzanthracene-treated) skin resulted in elevated levels of both the thioredoxin and glutaredoxin systems when examined 6 days after the last phorbol ester treatment.	Tetradecanoylphorbol Acetate	25-28	thioredoxin 1	Mus musculus	134-145
10469622-8	1999	Induction of thioredoxin, thioredoxin reductase and glutaredoxin activities by TPA and calcium ionophores may play a general role in the epigenetic mechanism of tumor promotion via thiol redox control mechanisms.	Tetradecanoylphorbol Acetate	79-82	thioredoxin 1	Mus musculus	13-24
10476784-15	1999	Staurosporine, PKC depletion, and TPA all enhanced ICAM-1 expression.	Tetradecanoylphorbol Acetate	34-37	intercellular adhesion molecule 1	Homo sapiens	51-57
10454570-0	1999	Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate.	Tetradecanoylphorbol Acetate	202-231	activating transcription factor 2	Homo sapiens	90-95
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	260-263	activating transcription factor 2	Homo sapiens	184-189
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	260-263	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	191-196
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	381-384	activating transcription factor 2	Homo sapiens	184-189
10454570-5	1999	The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1- but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA- but not in the IL-1-dependent stimulation of the uPA enhancer.	Tetradecanoylphorbol Acetate	381-384	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	191-196
10487519-4	1999	However, induction of K6-driven tTA expression by the tumor promoter (12-O-tetradecanoylphorbol-13-acetate) (TPA) led to very high levels of epidermal ODC activity and robust hyperplasia, especially involving hair follicles.	Tetradecanoylphorbol Acetate	70-106	ornithine decarboxylase, structural 1	Mus musculus	151-154
10487519-4	1999	However, induction of K6-driven tTA expression by the tumor promoter (12-O-tetradecanoylphorbol-13-acetate) (TPA) led to very high levels of epidermal ODC activity and robust hyperplasia, especially involving hair follicles.	Tetradecanoylphorbol Acetate	109-112	ornithine decarboxylase, structural 1	Mus musculus	151-154
10487519-6	1999	Finally, the number of papillomas that developed in a standard (7,12-dimethybenz[a]anthracene) (DMBA)/TPA protocol was greatly reduced in mice in which transgenic Odc expression was repressed by doxycycline.	Tetradecanoylphorbol Acetate	102-105	ornithine decarboxylase, structural 1	Mus musculus	163-166
10487519-7	1999	Our results demonstrated that the higher levels of ODC expression produced in the transgenic model in the induced versus the repressed condition make the normally promotion-resistant C57Bl/6 strain much more sensitive to the short-term and long-term (i.e., tumor-promoting) effects of TPA.	Tetradecanoylphorbol Acetate	285-288	ornithine decarboxylase, structural 1	Mus musculus	51-54
10441128-5	1999	Down regulation or inhibition of PKC greatly attenuated the PMA-induced phosphorylation as well as the activation of PLD1.	Tetradecanoylphorbol Acetate	60-63	protein kinase C, gamma	Rattus norvegicus	33-36
10452523-2	1999	The C1a and C1b domains play equivalent roles for translocation in response to phorbol 12-myristate 13-acetate, mezerein, and (-)octylindolactam V. These results contrast with those previously reported for PKC delta, suggesting that the domains play different roles in different PKC isoforms.	Tetradecanoylphorbol Acetate	79-110	protein kinase C, delta	Mus musculus	206-215
10415383-6	1999	The involvement of protein kinase C was demonstrated by the synergistic effect of TPA on PAF-stimulated tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	82-85	PCNA clamp associated factor	Rattus norvegicus	89-92
10411001-5	1999	HL-60 cells induced with phorbol myristate acetate (PMA) showed a rapid fourfold stimulation of CXCR4 mRNA within 1 h, declining to barely detectable levels at 3 h, with eventual restoration over time, mirroring the expression pattern in monocytes.	Tetradecanoylphorbol Acetate	25-50	C-X-C motif chemokine receptor 4	Homo sapiens	96-101
10411001-5	1999	HL-60 cells induced with phorbol myristate acetate (PMA) showed a rapid fourfold stimulation of CXCR4 mRNA within 1 h, declining to barely detectable levels at 3 h, with eventual restoration over time, mirroring the expression pattern in monocytes.	Tetradecanoylphorbol Acetate	52-55	C-X-C motif chemokine receptor 4	Homo sapiens	96-101
10403539-2	1999	AL-1 inhibited TPA-induced intracellular peroxide formation in differentiated HL-60 cells, suggesting that this suppression might be attributable to the inhibition of O2- generation.	Tetradecanoylphorbol Acetate	15-18	ephrin A5	Homo sapiens	0-4
10403548-0	1999	Inositol hexaphosphate reduces 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase independent of protein kinase C isoform expression in keratinocytes.	Tetradecanoylphorbol Acetate	31-67	ornithine decarboxylase, structural 1	Mus musculus	76-99
10403548-3	1999	In this study, we investigated the effect of InsP6 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity, an essential event in tumor promotion in HEL-30 cells, a murine keratinocyte cell line and SENCAR mouse skin.	Tetradecanoylphorbol Acetate	54-90	ornithine decarboxylase, structural 1	Mus musculus	105-128
10403548-3	1999	In this study, we investigated the effect of InsP6 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity, an essential event in tumor promotion in HEL-30 cells, a murine keratinocyte cell line and SENCAR mouse skin.	Tetradecanoylphorbol Acetate	54-90	ornithine decarboxylase, structural 1	Mus musculus	130-133
10403548-3	1999	In this study, we investigated the effect of InsP6 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity, an essential event in tumor promotion in HEL-30 cells, a murine keratinocyte cell line and SENCAR mouse skin.	Tetradecanoylphorbol Acetate	92-95	ornithine decarboxylase, structural 1	Mus musculus	105-128
10403548-8	1999	These results indicate that InsP6 reduces TPA-induced ODC activity independent of PKC isoform expression.	Tetradecanoylphorbol Acetate	42-45	ornithine decarboxylase, structural 1	Mus musculus	54-57
10354374-6	1999	Phorbol 12-myristate 13-acetate stimulation revealed that, among lymphocytes, cord blood B cells are the main cellular source of interleukin-10.	Tetradecanoylphorbol Acetate	0-31	interleukin 10	Homo sapiens	129-143
10344756-0	1999	Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells.	Tetradecanoylphorbol Acetate	28-64	KRAS proto-oncogene, GTPase	Homo sapiens	10-16
10344756-3	1999	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced immediate early genes, such as c-Jun, c-Fos, and Egr-1 in activated Ki-ras-disrupted clones, whereas c-Jun induction was rare in HCT116.	Tetradecanoylphorbol Acetate	0-36	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-94
10344756-3	1999	12-O-Tetradecanoylphorbol-13-acetate (TPA) induced immediate early genes, such as c-Jun, c-Fos, and Egr-1 in activated Ki-ras-disrupted clones, whereas c-Jun induction was rare in HCT116.	Tetradecanoylphorbol Acetate	0-36	KRAS proto-oncogene, GTPase	Homo sapiens	119-125
10352363-11	1999	Finally, ramipril completely abolished the PDGF A and B chain gene expression induced by phorbol 12-myristate 13-acetate, a specific protein kinase C activator, suggesting a site of action downstream of this enzyme in the mitogenic signal transduction pathway.	Tetradecanoylphorbol Acetate	89-120	platelet derived growth factor subunit A	Homo sapiens	43-55
10331502-5	1999	After incubation with phorbol myristate acetate (PMA) and ionomycin, the expression of DOR mRNA in splenocytes and T cells was significantly reduced compared with unstimulated cells in culture.	Tetradecanoylphorbol Acetate	22-47	opioid receptor, delta 1	Mus musculus	87-90
10331502-5	1999	After incubation with phorbol myristate acetate (PMA) and ionomycin, the expression of DOR mRNA in splenocytes and T cells was significantly reduced compared with unstimulated cells in culture.	Tetradecanoylphorbol Acetate	49-52	opioid receptor, delta 1	Mus musculus	87-90
10331502-6	1999	In addition, the inhibitory effect of PMA prevented anti-CD3-epsilon-stimulated DOR expression.	Tetradecanoylphorbol Acetate	38-41	opioid receptor, delta 1	Mus musculus	80-83
10329260-5	1999	Phorbol myristate acetate, known to induce protease activity in other endothelial cell populations, stimulated MMP1, MMP9, and TIMP1 secretion in both NDEC and PEDEC.	Tetradecanoylphorbol Acetate	0-25	matrix metallopeptidase 9	Homo sapiens	117-121
10320642-9	1999	After stimulation with A23187 and phorbol myristate acetate, an up-regulation of SCF mRNA was noted in HMC-1 and KU-812 cells, without changes in the relationship of the two splice variants.	Tetradecanoylphorbol Acetate	34-59	KIT ligand	Homo sapiens	81-84
10411311-7	1999	Overnight treatment with 4beta-phorbol 12-myristate 13-acetate, an activator of PKC, down-regulated PKC alpha, delta, and epsilon, but not PKC zeta.	Tetradecanoylphorbol Acetate	25-62	protein kinase C, alpha	Rattus norvegicus	100-129
10205165-4	1999	Treatment with phorbol 12-myristate 13-acetate (PMA) allows alphavbeta3 to locate to the focal adhesion contacts and the cells to spread on vitronectin in the presence of CKI peptides.	Tetradecanoylphorbol Acetate	15-46	vitronectin	Homo sapiens	140-151
10205165-4	1999	Treatment with phorbol 12-myristate 13-acetate (PMA) allows alphavbeta3 to locate to the focal adhesion contacts and the cells to spread on vitronectin in the presence of CKI peptides.	Tetradecanoylphorbol Acetate	48-51	vitronectin	Homo sapiens	140-151
9856820-5	1998	Increased production of IL-4 and IL-13 in both CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells after 4 h in vitro stimulation with phorbol 12-myristate 13-acetate and ionomycin, was more prominent in AD-H patients than in AD-L patients or healthy controls, whereas IFN-gamma-producing CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells were relatively diminished in AD-H patients.	Tetradecanoylphorbol Acetate	129-160	CD8a molecule	Homo sapiens	72-75
9843579-16	1998	Activation of PKC by phorbol ester (12-O-tetradecanoylphorbol-13-acetate) induced and attachment-dependent phosphorylation of both cPLA2 and ERK2 in suspension cells.	Tetradecanoylphorbol Acetate	36-72	phospholipase A2 group IVA	Homo sapiens	131-136
9792719-8	1998	Down-regulation of PKC by prolonged treatment with 4beta-phorbol 12-myristate 13-acetate also abolished H2O2-stimulated PLD activity.	Tetradecanoylphorbol Acetate	51-88	protein kinase C, alpha	Rattus norvegicus	19-22
9827570-5	1998	OAT1-mediated PAH uptake was markedly inhibited by phorbol 12-myristate 13-acetate (PMA), phorbol 12,13-dibutyrate and mezerein, but not by 4alpha-phorbol 12,13-didecanoate.	Tetradecanoylphorbol Acetate	51-82	solute carrier family 22 member 6	Rattus norvegicus	0-4
9827570-5	1998	OAT1-mediated PAH uptake was markedly inhibited by phorbol 12-myristate 13-acetate (PMA), phorbol 12,13-dibutyrate and mezerein, but not by 4alpha-phorbol 12,13-didecanoate.	Tetradecanoylphorbol Acetate	84-87	solute carrier family 22 member 6	Rattus norvegicus	0-4
9834970-1	1998	Rotenone is the classical inhibitor of NADH: ubiquinone oxidoreductase and its analogue deguelin is a potent inhibitor of 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase mRNA steady state level and enzyme activity in mouse 308 cells (Gerhauser et al.	Tetradecanoylphorbol Acetate	122-158	ornithine decarboxylase, structural 1	Mus musculus	173-196
9834970-1	1998	Rotenone is the classical inhibitor of NADH: ubiquinone oxidoreductase and its analogue deguelin is a potent inhibitor of 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase mRNA steady state level and enzyme activity in mouse 308 cells (Gerhauser et al.	Tetradecanoylphorbol Acetate	160-163	ornithine decarboxylase, structural 1	Mus musculus	173-196
10216261-7	1999	We performed a primer extension analysis using mRNA from HeLa S3 cells stimulated with phorbol 12-myristate 13-acetate (PMA), Ca2+ ionophore A23187 and cycloheximide (CHX) in order to induce the Nurr1 mRNA expression, and determined one transcription initiation site within CRE.	Tetradecanoylphorbol Acetate	87-118	nuclear receptor subfamily 4 group A member 2	Homo sapiens	195-200
10094832-4	1999	This enhanced adhesion was mediated by alpha2beta1 integrin, since both anti-alpha2 and anti-beta1 blocking antibodies each completely abrogated the TPA-induced adhesion.	Tetradecanoylphorbol Acetate	149-152	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	45-50
3119281-0	1987	Treatment of mouse L-cells with phorbol myristate acetate induces the secretion of a plasminogen activator inhibitor which binds to human and mouse urokinase and human tissue plasminogen activator.	Tetradecanoylphorbol Acetate	32-57	chromosome 20 open reading frame 181	Homo sapiens	168-196
10094832-8	1999	Northern blot analysis revealed that mRNA levels of both alpha2 and beta1 subunits were increased after exposure to TPA for 4 h, indicating that the induction of alpha2beta1 mRNA preceded that of its cell surface expression.	Tetradecanoylphorbol Acetate	116-119	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	68-73
10188728-1	1999	Treatment with low (nanomolar) concentrations of phorbol-12-myristate-13-acetate (PMA) for 5 to 30 min suppresses locomotion of Walker 256 carcinosarcoma cells, suggesting that activation of protein kinase C (PKC) is a stop signal for tumor cell locomotion.	Tetradecanoylphorbol Acetate	49-80	protein kinase C, alpha	Rattus norvegicus	209-212
9730868-5	1998	In contrast, C5a- and PMA-induced adhesion to TNF-alpha/IFN-gamma-activated NHBEC (increased from 11.1 +/- 1.3% to 21.9 +/- 1.0% and 27.6 +/- 1.9%, respectively) was CD18- and ICAM-1-dependent.	Tetradecanoylphorbol Acetate	22-25	intercellular adhesion molecule 1	Homo sapiens	176-182
3609441-5	1987	Addition of alpha-amanitin abolished the 12 hr peak, but the TPA induced ODC activity was only partly inhibited.	Tetradecanoylphorbol Acetate	61-64	ornithine decarboxylase, structural 1	Mus musculus	73-76
10188728-1	1999	Treatment with low (nanomolar) concentrations of phorbol-12-myristate-13-acetate (PMA) for 5 to 30 min suppresses locomotion of Walker 256 carcinosarcoma cells, suggesting that activation of protein kinase C (PKC) is a stop signal for tumor cell locomotion.	Tetradecanoylphorbol Acetate	82-85	protein kinase C, alpha	Rattus norvegicus	209-212
10188728-5	1999	Long-term incubation with PMA (0.1 microM, 6 hr) resulted in significant reduction of expression of conventional PKCs alpha, betaI, betaII and gamma and of the novel PKC eta to 10% to 26% of controls.	Tetradecanoylphorbol Acetate	26-29	protein kinase C, alpha	Rattus norvegicus	113-148
9743233-8	1998	Moreover, phorbol 12-myristate 13-acetate, H2O2, or the combination of H2O2 and sodium orthovanadate (vanadate) activated c-Jun-activating kinase.	Tetradecanoylphorbol Acetate	10-41	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	122-127
10188728-5	1999	Long-term incubation with PMA (0.1 microM, 6 hr) resulted in significant reduction of expression of conventional PKCs alpha, betaI, betaII and gamma and of the novel PKC eta to 10% to 26% of controls.	Tetradecanoylphorbol Acetate	26-29	protein kinase C, alpha	Rattus norvegicus	113-116
3609441-6	1987	ODC induction by TPA was lower in C3H/10T1/2 CL8 cells initiated with 3-methyl-cholanthrene (MCA).	Tetradecanoylphorbol Acetate	17-20	ornithine decarboxylase, structural 1	Mus musculus	0-3
10188728-9	1999	Motility and polarized shape of the down-regulated cells were no longer susceptible to short-term treatment with PMA, showing that active PKC is indeed responsible for the inhibitory effects of PMA.	Tetradecanoylphorbol Acetate	113-116	protein kinase C, alpha	Rattus norvegicus	138-141
3609441-7	1987	ODC increased with TPA up to 10(-7) M and decreased at higher concentrations of TPA.	Tetradecanoylphorbol Acetate	19-22	ornithine decarboxylase, structural 1	Mus musculus	0-3
10188728-9	1999	Motility and polarized shape of the down-regulated cells were no longer susceptible to short-term treatment with PMA, showing that active PKC is indeed responsible for the inhibitory effects of PMA.	Tetradecanoylphorbol Acetate	194-197	protein kinase C, alpha	Rattus norvegicus	138-141
9731481-6	1998	In PANC-1 human pancreatic cancer cells, steady-state Id2 mRNA levels increased upon serum addition and decreased after induction of differentiation with either sodium butyrate or 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	180-216	inhibitor of DNA binding 2	Homo sapiens	54-57
10209302-6	1999	10 nM TNF-alpha pretreatment also suppressed 10 nM insulin- and 1 microM TPA-induced increases in membrane-associated PKCbeta and PKCzeta.	Tetradecanoylphorbol Acetate	73-76	protein kinase C, beta	Rattus norvegicus	118-125
3609441-7	1987	ODC increased with TPA up to 10(-7) M and decreased at higher concentrations of TPA.	Tetradecanoylphorbol Acetate	80-83	ornithine decarboxylase, structural 1	Mus musculus	0-3
3027109-2	1987	HM3-11 and HM3-14 produce two molecular species of CSF, which are not found in the conditioned media from cultures of BAM1 and BAM3 or lipopolysaccharide (LPS), phorbolmyristate-acetate (PMA), and zymosan-stimulated BAM3.	Tetradecanoylphorbol Acetate	187-190	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	51-54
10225479-2	1999	The treatment with 10 nmol/L 12-tetra decanoylphorbol-13-acetate (TPA) for more than 2 hours decreased PKC activity by approximately 80% without marked hypertrophy.	Tetradecanoylphorbol Acetate	66-69	protein kinase C, gamma	Rattus norvegicus	103-106
9768595-7	1998	IL-3, as well as the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate, caused a shift in the electrophoretic mobility of cPLA2, which indicated phosphorylation of cPLA2 and therefore its activation.	Tetradecanoylphorbol Acetate	54-85	phospholipase A2 group IVA	Homo sapiens	137-142
9768595-7	1998	IL-3, as well as the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate, caused a shift in the electrophoretic mobility of cPLA2, which indicated phosphorylation of cPLA2 and therefore its activation.	Tetradecanoylphorbol Acetate	54-85	phospholipase A2 group IVA	Homo sapiens	179-184
10460017-8	1999	The present study suggested that the activation of early c-fos response gene by TPA might be another mechanism to enhance the effect of 1,25-(OH)2D3, besides up-regulation of VDR.	Tetradecanoylphorbol Acetate	80-83	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-62
3119603-7	1987	Fibroblast growth factor (FGF) and the tumor promoter phorbol myristate acetate (TPA) induce the c-fos gene but not this DNA-binding activity.	Tetradecanoylphorbol Acetate	54-79	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	97-102
10460017-8	1999	The present study suggested that the activation of early c-fos response gene by TPA might be another mechanism to enhance the effect of 1,25-(OH)2D3, besides up-regulation of VDR.	Tetradecanoylphorbol Acetate	80-83	vitamin D receptor	Homo sapiens	175-178
10201899-6	1999	In contrast, PMA-induced JNK activation is inhibited by Ca2+ ionophore.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 8	Mus musculus	25-28
9868866-1	1998	The correlation between ornithine decarboxylase (ODC) protein induction and specific protein kinase C (PKC) isozyme expression by gamma-ray in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated normal and v-rasHa transformed mouse keratinocytes was examined.	Tetradecanoylphorbol Acetate	181-184	ornithine decarboxylase, structural 1	Mus musculus	24-47
9868866-1	1998	The correlation between ornithine decarboxylase (ODC) protein induction and specific protein kinase C (PKC) isozyme expression by gamma-ray in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated normal and v-rasHa transformed mouse keratinocytes was examined.	Tetradecanoylphorbol Acetate	181-184	ornithine decarboxylase, structural 1	Mus musculus	49-52
9868866-6	1998	Gamma-ray increases ODC protein expression in both TPA-treated normal and v-rasHa transformed mouse keratinocytes and this phenomenon correlated to the increased induction of PKC alpha without altering other PKC isozymes.	Tetradecanoylphorbol Acetate	51-54	ornithine decarboxylase, structural 1	Mus musculus	20-23
9868866-8	1998	These results indicate that PKC alpha as an important regulator of mouse epidermal changes by gamma-radiation, contributes to the ODC expression occurring during exposure to tumor promoter, such as TPA, and epidermal neoplasia induced by ras activation.	Tetradecanoylphorbol Acetate	198-201	ornithine decarboxylase, structural 1	Mus musculus	130-133
10087019-3	1999	We examined the effects of activation of endogenous PKC by 4beta-phorbol 12-myristate 13-acetate (PMA) and dialysis of cells with PKM and a pseudosubstrate inhibitor PKC(19-31) (PKC-I) on kappa- and mu-opioid-mediated inhibition of calcium current, calcium current amplitude, and rundown.	Tetradecanoylphorbol Acetate	59-96	protein kinase C, gamma	Rattus norvegicus	52-55
3119603-7	1987	Fibroblast growth factor (FGF) and the tumor promoter phorbol myristate acetate (TPA) induce the c-fos gene but not this DNA-binding activity.	Tetradecanoylphorbol Acetate	81-84	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	97-102
10087019-3	1999	We examined the effects of activation of endogenous PKC by 4beta-phorbol 12-myristate 13-acetate (PMA) and dialysis of cells with PKM and a pseudosubstrate inhibitor PKC(19-31) (PKC-I) on kappa- and mu-opioid-mediated inhibition of calcium current, calcium current amplitude, and rundown.	Tetradecanoylphorbol Acetate	98-101	protein kinase C, gamma	Rattus norvegicus	52-55
10087019-4	1999	PMA modestly increased peak calcium current and substantially reduced calcium current "rundown," effects blocked by PKC-I.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, gamma	Rattus norvegicus	116-121
3099293-5	1987	The expression of MYC and FOS was rapidly induced by the phorbol 12-myristate 13-acetate treatment.	Tetradecanoylphorbol Acetate	57-88	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	26-29
9766437-9	1998	Ha-ras exon I codons 12 and 13 were mutated in 11 of 19 tumors (58%) from mice given AZT and TPA and in one of 15 tumors (7%) from mice given TPA alone (P= 0.004).	Tetradecanoylphorbol Acetate	93-96	Harvey rat sarcoma virus oncogene	Mus musculus	0-6
10382944-2	1999	A secondary objective was to determine whether apoptosis induced by ATO compared with VP-16 is differentially affected by an activator of protein kinase C (PKC), phorbol 12-myristate 13-acetate (PMA), which has been reported to inhibit apoptosis induced by some chemotherapeutic agents.	Tetradecanoylphorbol Acetate	162-193	host cell factor C1	Homo sapiens	86-91
9766437-9	1998	Ha-ras exon I codons 12 and 13 were mutated in 11 of 19 tumors (58%) from mice given AZT and TPA and in one of 15 tumors (7%) from mice given TPA alone (P= 0.004).	Tetradecanoylphorbol Acetate	142-145	Harvey rat sarcoma virus oncogene	Mus musculus	0-6
3096578-6	1986	Finally, transcription of c-fos in A431 cells is markedly induced by the tumor promoter TPA and the calcium ionophore A23187, yet neither induced an increased level of the enhancer-binding activity.	Tetradecanoylphorbol Acetate	88-91	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	26-31
9743209-5	1998	In activated T cells toremifene clearly inhibits phorbol 12-myristate 13-acetate (PMA)-induced JNK activity, suggesting that the JNK pathway may also be involved in the up-regulation of TNF-R2 expression by antioestrogens.	Tetradecanoylphorbol Acetate	49-80	TNF receptor superfamily member 1B	Homo sapiens	186-192
9743209-5	1998	In activated T cells toremifene clearly inhibits phorbol 12-myristate 13-acetate (PMA)-induced JNK activity, suggesting that the JNK pathway may also be involved in the up-regulation of TNF-R2 expression by antioestrogens.	Tetradecanoylphorbol Acetate	82-85	TNF receptor superfamily member 1B	Homo sapiens	186-192
10382944-2	1999	A secondary objective was to determine whether apoptosis induced by ATO compared with VP-16 is differentially affected by an activator of protein kinase C (PKC), phorbol 12-myristate 13-acetate (PMA), which has been reported to inhibit apoptosis induced by some chemotherapeutic agents.	Tetradecanoylphorbol Acetate	195-198	host cell factor C1	Homo sapiens	86-91
10085163-12	1999	Long term treatment of cells with TPA is known to down-regulate PKC.	Tetradecanoylphorbol Acetate	34-37	protein kinase C, gamma	Rattus norvegicus	64-67
10085163-14	1999	TPA treatment of 3T3-F442A adipocytes decreased PKC alpha, beta, delta, and epsilon isoforms, whereas PKC lambda, theta, zeta, micro, iota, and gamma remained unchanged or decreased minimally.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	48-138
9683525-16	1998	The level of PKC mu was constant; however, a slow mobility form was observed in TPA-treated cells.	Tetradecanoylphorbol Acetate	80-83	protein kinase D1	Homo sapiens	13-19
2946598-2	1986	However, when BM cells are treated with LPS and the tumor-promoting phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) simultaneously, they generate significant levels of CSF.	Tetradecanoylphorbol Acetate	82-119	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	178-181
9683525-19	1998	This arrest, in turn, is associated with a shift of PKC isozymes PKC alpha, PKC betaI, PKC betaII, PKC delta, PKC epsilon, and PKC mu to the membrane fraction which is induced by addition of TPA.	Tetradecanoylphorbol Acetate	191-194	protein kinase D1	Homo sapiens	127-133
9683538-10	1998	Treatment of F3II cells, with phorbol myristate acetate (PMA) or phosphatidic acid (PA, the product of PLD-dependent hydrolysis of phosphatidylcholine), significantly enhanced CD44 expression.	Tetradecanoylphorbol Acetate	30-55	CD44 antigen	Mus musculus	176-180
9683538-10	1998	Treatment of F3II cells, with phorbol myristate acetate (PMA) or phosphatidic acid (PA, the product of PLD-dependent hydrolysis of phosphatidylcholine), significantly enhanced CD44 expression.	Tetradecanoylphorbol Acetate	57-60	CD44 antigen	Mus musculus	176-180
10082883-7	1999	The effects of choline and cytidine were enhanced by 12-O-tetradecanoylphorbol-13-acetate (TPA, 1 microM), which activates CTP:phosphocholine cytidylyltransferase (CT) and facilitates choline uptake.	Tetradecanoylphorbol Acetate	53-89	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	123-162
10082883-7	1999	The effects of choline and cytidine were enhanced by 12-O-tetradecanoylphorbol-13-acetate (TPA, 1 microM), which activates CTP:phosphocholine cytidylyltransferase (CT) and facilitates choline uptake.	Tetradecanoylphorbol Acetate	91-94	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	123-162
2946598-2	1986	However, when BM cells are treated with LPS and the tumor-promoting phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) simultaneously, they generate significant levels of CSF.	Tetradecanoylphorbol Acetate	121-124	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	178-181
2946598-5	1986	B-lymphocytes may be the main source of the CSF from BM cells, since BM cells adherent to surfaces coated with goat antimouse immunoglobulin produced CSF in amounts similar to those produced by unseparated BM cells after stimulation with LPS and TPA.	Tetradecanoylphorbol Acetate	246-249	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	44-47
9744516-1	1998	The effects of three inducers of differentiation, phorbol myristate acetate (PMA), retinoic acid (RA) and interferon-gamma (IFN-gamma), on the temporal regulation of vitamin D receptor (VDR) expression in HL-60 cells were analyzed by Northern blotting and immunofluorescence assays.	Tetradecanoylphorbol Acetate	50-75	vitamin D receptor	Homo sapiens	166-184
9744516-1	1998	The effects of three inducers of differentiation, phorbol myristate acetate (PMA), retinoic acid (RA) and interferon-gamma (IFN-gamma), on the temporal regulation of vitamin D receptor (VDR) expression in HL-60 cells were analyzed by Northern blotting and immunofluorescence assays.	Tetradecanoylphorbol Acetate	50-75	vitamin D receptor	Homo sapiens	186-189
9744516-1	1998	The effects of three inducers of differentiation, phorbol myristate acetate (PMA), retinoic acid (RA) and interferon-gamma (IFN-gamma), on the temporal regulation of vitamin D receptor (VDR) expression in HL-60 cells were analyzed by Northern blotting and immunofluorescence assays.	Tetradecanoylphorbol Acetate	77-80	vitamin D receptor	Homo sapiens	166-184
10066432-6	1999	Therefore, we suggest that PMA-induced activation of PKC leads to protease-mediated shedding of CD163.	Tetradecanoylphorbol Acetate	27-30	CD163 molecule	Homo sapiens	96-101
3102248-10	1986	Second, with regard to the requirements for receptor expression, it was observed that either anti-Ig or phorbol diester (phorbol-12-myristate 13-acetate) can induce IL 2R and IL 2 responsiveness (proliferation assay) in LPS blasts but not in fresh B cells.	Tetradecanoylphorbol Acetate	121-152	interleukin 2 receptor, alpha chain	Mus musculus	165-170
10100637-5	1999	Cells expressing the large subunit of RNA polymerase II and LSdelta31 were able to transcribe the c-fos and hsp70A genes after treatment with the phorbolester TPA and after heat-shock, respectively.	Tetradecanoylphorbol Acetate	159-162	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-103
3540941-2	1986	Phorbol 12-myristate 13-acetate pretreatment abolished the increase in c-fos mRNA due to additional phorbol 12-myristate 13-acetate treatment and decreased but did not eliminate the ability of platelet-derived growth factor, fibroblast growth factor, fetal calf serum, bombesin, and insulin to stimulate c-fos mRNA.	Tetradecanoylphorbol Acetate	0-31	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-76
10209066-3	1999	It was found that individual members of the signal transducer and activator of transcription (STAT) family are regulated by ciliary neurotrophic factor (CNTF) and by protein kinase C. Treatment of SH-SY5Y human neuroblastoma cells with the phorbol ester, 12- O -tetradecanoylphorbol 13-acetate (TPA), for 4-5 h caused a 60% decline in both STAT2 and STAT3 levels and no decline in levels of STATs 1, 5 or 6, or in Jaks 1 or 2.	Tetradecanoylphorbol Acetate	255-293	ciliary neurotrophic factor	Homo sapiens	124-151
10209066-3	1999	It was found that individual members of the signal transducer and activator of transcription (STAT) family are regulated by ciliary neurotrophic factor (CNTF) and by protein kinase C. Treatment of SH-SY5Y human neuroblastoma cells with the phorbol ester, 12- O -tetradecanoylphorbol 13-acetate (TPA), for 4-5 h caused a 60% decline in both STAT2 and STAT3 levels and no decline in levels of STATs 1, 5 or 6, or in Jaks 1 or 2.	Tetradecanoylphorbol Acetate	255-293	ciliary neurotrophic factor	Homo sapiens	153-157
10209066-3	1999	It was found that individual members of the signal transducer and activator of transcription (STAT) family are regulated by ciliary neurotrophic factor (CNTF) and by protein kinase C. Treatment of SH-SY5Y human neuroblastoma cells with the phorbol ester, 12- O -tetradecanoylphorbol 13-acetate (TPA), for 4-5 h caused a 60% decline in both STAT2 and STAT3 levels and no decline in levels of STATs 1, 5 or 6, or in Jaks 1 or 2.	Tetradecanoylphorbol Acetate	295-298	ciliary neurotrophic factor	Homo sapiens	124-151
10209066-3	1999	It was found that individual members of the signal transducer and activator of transcription (STAT) family are regulated by ciliary neurotrophic factor (CNTF) and by protein kinase C. Treatment of SH-SY5Y human neuroblastoma cells with the phorbol ester, 12- O -tetradecanoylphorbol 13-acetate (TPA), for 4-5 h caused a 60% decline in both STAT2 and STAT3 levels and no decline in levels of STATs 1, 5 or 6, or in Jaks 1 or 2.	Tetradecanoylphorbol Acetate	295-298	ciliary neurotrophic factor	Homo sapiens	153-157
9658145-6	1998	Furthermore, phorbol myristate acetate and membrane-targeted HIV-1 Nef also enhanced the LTR activity in the presence of Tat in the TAR- and kappaB cis element-dependent manner.	Tetradecanoylphorbol Acetate	13-38	Tat	Human immunodeficiency virus 1	121-124
9689011-10	1998	The effect of ATP or PMA was reversed by the PKC inhibitors Ro-31-8220 (10(-8) M) and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (10(-5) M), indicating that suppression of iNOS is mediated via activation of PKC through stimulated P2Y2 receptors.	Tetradecanoylphorbol Acetate	21-24	purinergic receptor P2Y2	Rattus norvegicus	234-238
3540941-2	1986	Phorbol 12-myristate 13-acetate pretreatment abolished the increase in c-fos mRNA due to additional phorbol 12-myristate 13-acetate treatment and decreased but did not eliminate the ability of platelet-derived growth factor, fibroblast growth factor, fetal calf serum, bombesin, and insulin to stimulate c-fos mRNA.	Tetradecanoylphorbol Acetate	0-31	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	304-309
9973202-3	1999	Treatment with the biologically active phorbol ester 12-O-tetradecanoylphorbol-13-acetate or with membrane-permeable diacylglycerols also stimulated PKD activation, which was also completely prevented by prior exposure of the cells to GF I.	Tetradecanoylphorbol Acetate	53-89	protein kinase D1	Homo sapiens	149-152
3540941-2	1986	Phorbol 12-myristate 13-acetate pretreatment abolished the increase in c-fos mRNA due to additional phorbol 12-myristate 13-acetate treatment and decreased but did not eliminate the ability of platelet-derived growth factor, fibroblast growth factor, fetal calf serum, bombesin, and insulin to stimulate c-fos mRNA.	Tetradecanoylphorbol Acetate	100-131	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-76
9690620-0	1998	Binding of ETS family members is important for the function of the c-sis/platelet-derived growth factor-B TATA neighboring sequence in 12-O-tetradecanoylphorbol-13-acetate-treated K562 cells.	Tetradecanoylphorbol Acetate	135-171	platelet derived growth factor subunit B	Homo sapiens	67-72
3540941-4	1986	Cycloheximide treatment in combination with insulin or phorbol 12-myristate 13-acetate resulted in superinduction of c-fos mRNA.	Tetradecanoylphorbol Acetate	55-86	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	117-122
9690620-1	1998	The c-sis/platelet-derived growth factor (PDGF)-B TATA neighboring sequence (TNS) is a promoter element that is required for the full induction of this gene in K562 erythroleukemia cells undergoing 12-O-tetradecanoylphorbol-13-acetate-mediated megakaryoblastic differentiation.	Tetradecanoylphorbol Acetate	198-234	platelet derived growth factor subunit B	Homo sapiens	4-9
9690620-1	1998	The c-sis/platelet-derived growth factor (PDGF)-B TATA neighboring sequence (TNS) is a promoter element that is required for the full induction of this gene in K562 erythroleukemia cells undergoing 12-O-tetradecanoylphorbol-13-acetate-mediated megakaryoblastic differentiation.	Tetradecanoylphorbol Acetate	198-234	platelet derived growth factor subunit B	Homo sapiens	42-49
10426567-0	1999	Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway.	Tetradecanoylphorbol Acetate	260-291	protein kinase C zeta	Homo sapiens	51-54
3490509-8	1986	Generation of promiscuous killing activity by PMA and ionomycin, on the other hand, was class I independent.	Tetradecanoylphorbol Acetate	46-49	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	Mus musculus	88-95
10426567-0	1999	Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway.	Tetradecanoylphorbol Acetate	293-296	protein kinase C zeta	Homo sapiens	51-54
9618150-6	1998	Cotransfection with dominant-negative p85 or with dominant-negative Ras also produced down-regulation of the insulin or IGF-I-induced 12-O-tetradecanoylphorbol-13-acetate response element (TRE)-CAT (five AP-1, activating protein-1, binding sites arranged in tandem) transactivation.	Tetradecanoylphorbol Acetate	134-170	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	38-41
9678170-7	1998	Upon concurrent stimulation of EL4.IL-2 cells with phorbol 12-myristate-13-acetate, seven of the eight strains displayed significant enhancement of IL-2 and IL-5 production, with S. thermophilus being most effective.	Tetradecanoylphorbol Acetate	51-82	epilepsy 4	Mus musculus	31-34
9632805-5	1998	Syk-deficient neutrophils derived from the bone marrow were incapable of generating reactive oxygen intermediates in response to FcgammaR engagement but responded normally to tetradecanoyl phorbol acetate stimulation.	Tetradecanoylphorbol Acetate	175-204	spleen tyrosine kinase	Mus musculus	0-3
9604867-12	1998	Prolonged treatment of the cells with TPA downregulated PKC-alpha and -beta, but not PKC-zeta.	Tetradecanoylphorbol Acetate	38-41	protein kinase C, alpha	Rattus norvegicus	56-75
9604717-6	1998	Contralateral ears from AA- or TPA-treated mice also showed a significant increase in MPO levels.	Tetradecanoylphorbol Acetate	31-34	myeloperoxidase	Mus musculus	86-89
9614208-5	1998	The response of prolactin mRNA to TGF-beta2 was inhibited by preincubation of cells with phorbol-12-myristate-13-acetate, which down-regulated protein kinase C (PKC).	Tetradecanoylphorbol Acetate	89-120	protein kinase C, gamma	Rattus norvegicus	161-164
9655185-6	1998	Also down-regulation of PKC alpha and epsilon, the major isotypes of PKC in BPAECs, by TPA (100 nM, 18 h) did not attenuate the DPV-induced PLD activation.	Tetradecanoylphorbol Acetate	87-90	protein kinase C alpha	Bos taurus	24-33
9655185-6	1998	Also down-regulation of PKC alpha and epsilon, the major isotypes of PKC in BPAECs, by TPA (100 nM, 18 h) did not attenuate the DPV-induced PLD activation.	Tetradecanoylphorbol Acetate	87-90	protein kinase C alpha	Bos taurus	24-27
9655185-7	1998	The effects of putative tyrosine kinase and PKC inhibitors were specific as determined by comparing [32P] PBt formation between DPV and TPA.	Tetradecanoylphorbol Acetate	136-139	protein kinase C alpha	Bos taurus	44-47
9593690-4	1998	Cytochalasin-D treatment of SNB19 cells resulted in the loss of phorbol 12-myristate 13-acetate-induced matrix metalloproteinase-9 (also known as gelatinase-B) expression and coincided with inhibition of actin polymerization, resulting in cell rounding.	Tetradecanoylphorbol Acetate	64-95	matrix metallopeptidase 9	Homo sapiens	104-130
9593752-10	1998	The protein kinase C activator phorbol 12-myristate 13-acetate, a phorbol ester, as well as 1-oleoyl-2-acetoyl-3-glycerol, a cell-permeable diacylglycerol analog, also stimulated APP-S secretion.	Tetradecanoylphorbol Acetate	31-62	cathepsin B	Homo sapiens	179-184
9630570-6	1998	Further, the data also showed that the protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA 150 nM) reduced the spreading of the waves.	Tetradecanoylphorbol Acetate	72-103	protein kinase C, gamma	Rattus norvegicus	39-55
9630570-6	1998	Further, the data also showed that the protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA 150 nM) reduced the spreading of the waves.	Tetradecanoylphorbol Acetate	72-103	protein kinase C, gamma	Rattus norvegicus	57-60
9630570-6	1998	Further, the data also showed that the protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA 150 nM) reduced the spreading of the waves.	Tetradecanoylphorbol Acetate	105-108	protein kinase C, gamma	Rattus norvegicus	39-55
9602173-6	1998	We found that c-Fos, a bZip protein known to be induced by serum and TPA, is sufficient to antagonize the JunD function.	Tetradecanoylphorbol Acetate	69-72	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
9600091-1	1998	The expression of the neuropeptide galanin (GAL) is elevated in vivo upon nerve stimulation, injury, and in vitro by phorbol 12-myristate-13-acetate (PMA), suggesting that a signal pathway involving protein kinase C activation may be involved in GAL-gene activation.	Tetradecanoylphorbol Acetate	117-148	galanin and GMAP prepropeptide	Homo sapiens	35-42
9600091-1	1998	The expression of the neuropeptide galanin (GAL) is elevated in vivo upon nerve stimulation, injury, and in vitro by phorbol 12-myristate-13-acetate (PMA), suggesting that a signal pathway involving protein kinase C activation may be involved in GAL-gene activation.	Tetradecanoylphorbol Acetate	117-148	galanin and GMAP prepropeptide	Homo sapiens	44-47
9600091-1	1998	The expression of the neuropeptide galanin (GAL) is elevated in vivo upon nerve stimulation, injury, and in vitro by phorbol 12-myristate-13-acetate (PMA), suggesting that a signal pathway involving protein kinase C activation may be involved in GAL-gene activation.	Tetradecanoylphorbol Acetate	150-153	galanin and GMAP prepropeptide	Homo sapiens	35-42
9600091-1	1998	The expression of the neuropeptide galanin (GAL) is elevated in vivo upon nerve stimulation, injury, and in vitro by phorbol 12-myristate-13-acetate (PMA), suggesting that a signal pathway involving protein kinase C activation may be involved in GAL-gene activation.	Tetradecanoylphorbol Acetate	150-153	galanin and GMAP prepropeptide	Homo sapiens	44-47
9572838-6	1998	PTH/PTHrP receptor phosphorylation in ROS 17/2.8, COS-7, and LLCPK-1 cells was also stimulated with forskolin and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	114-139	parathyroid hormone-like hormone	Rattus norvegicus	4-9
9572838-6	1998	PTH/PTHrP receptor phosphorylation in ROS 17/2.8, COS-7, and LLCPK-1 cells was also stimulated with forskolin and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	141-144	parathyroid hormone-like hormone	Rattus norvegicus	4-9
9615391-4	1998	At equimolar concentrations (10 nM), PMA, in contrast to bryostatin 1, induced cellular differentiation of U937 cells, reflected by growth inhibition, increased plastic adhesion, and expression of the monocytic differentiation marker, CD11b.	Tetradecanoylphorbol Acetate	37-40	integrin subunit alpha M	Homo sapiens	235-240
9603471-4	1998	In contrast, the phorbol 12-myristate 13-acetate (PMA)-induced IL-10 production and CD69 expression, and the ionomycin plus PMA-induced IL-2 production are not affected.	Tetradecanoylphorbol Acetate	17-48	interleukin 10	Homo sapiens	63-68
9603471-4	1998	In contrast, the phorbol 12-myristate 13-acetate (PMA)-induced IL-10 production and CD69 expression, and the ionomycin plus PMA-induced IL-2 production are not affected.	Tetradecanoylphorbol Acetate	50-53	interleukin 10	Homo sapiens	63-68
9525478-9	1998	The inhibitory effect of [Ca++]i chelation on beta1 integrin activation was reversed by repleting [Ca++]i with ionomycin in a Ca++-containing buffer, or by the addition of higher concentrations of PMA (10 ng/ml).	Tetradecanoylphorbol Acetate	197-200	integrin subunit beta 1	Homo sapiens	46-60
9570757-8	1998	PCNA immunoreactivity significantly increased after 8 hours treatment of RA or TPA, suggesting a hyperproliferative growth response.	Tetradecanoylphorbol Acetate	79-82	proliferating cell nuclear antigen	Rattus norvegicus	0-4
9570757-9	1998	Epidermal hyperplasia was confirmed by monitoring the expression patterns of K10 and K14 in RA- or TPA-treated skin.	Tetradecanoylphorbol Acetate	99-102	keratin 14	Rattus norvegicus	85-88
9573531-2	1998	The promoter regions of certain ECM genes contain TPA (phorbol ester)-responsive element (TRE) motifs that bind the transcription factor, activator protein-1 (AP-1), a complex of Jun and other phosphoproteins.	Tetradecanoylphorbol Acetate	50-53	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-157
9573531-2	1998	The promoter regions of certain ECM genes contain TPA (phorbol ester)-responsive element (TRE) motifs that bind the transcription factor, activator protein-1 (AP-1), a complex of Jun and other phosphoproteins.	Tetradecanoylphorbol Acetate	50-53	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	159-163
9585067-5	1998	When it was applied to the dorsal surface of CD-1 mice before TPA application, PCA (5, 10 or 20 micromol) inhibited the induction of epidermal ornithine decarboxylase (ODC) activity by 5 nmol TPA and myeloperoxidase (MPO) activity by 6.5 nmol TPA.	Tetradecanoylphorbol Acetate	192-195	ornithine decarboxylase, structural 1	Mus musculus	143-166
9585067-5	1998	When it was applied to the dorsal surface of CD-1 mice before TPA application, PCA (5, 10 or 20 micromol) inhibited the induction of epidermal ornithine decarboxylase (ODC) activity by 5 nmol TPA and myeloperoxidase (MPO) activity by 6.5 nmol TPA.	Tetradecanoylphorbol Acetate	192-195	ornithine decarboxylase, structural 1	Mus musculus	168-171
9585067-5	1998	When it was applied to the dorsal surface of CD-1 mice before TPA application, PCA (5, 10 or 20 micromol) inhibited the induction of epidermal ornithine decarboxylase (ODC) activity by 5 nmol TPA and myeloperoxidase (MPO) activity by 6.5 nmol TPA.	Tetradecanoylphorbol Acetate	192-195	ornithine decarboxylase, structural 1	Mus musculus	143-166
9585067-5	1998	When it was applied to the dorsal surface of CD-1 mice before TPA application, PCA (5, 10 or 20 micromol) inhibited the induction of epidermal ornithine decarboxylase (ODC) activity by 5 nmol TPA and myeloperoxidase (MPO) activity by 6.5 nmol TPA.	Tetradecanoylphorbol Acetate	192-195	ornithine decarboxylase, structural 1	Mus musculus	168-171
9526000-2	1998	In AtT-20 cells transfected with rat cannabinoid receptor (CB1), the activation of an inwardly rectifying potassium current (Kir current) and depression of P/Q-type calcium channels by cannabinoids were prevented by stimulation of protein kinase C by 100 nM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	258-289	cannabinoid receptor 1	Rattus norvegicus	59-62
9526000-2	1998	In AtT-20 cells transfected with rat cannabinoid receptor (CB1), the activation of an inwardly rectifying potassium current (Kir current) and depression of P/Q-type calcium channels by cannabinoids were prevented by stimulation of protein kinase C by 100 nM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	258-289	protein kinase C, gamma	Rattus norvegicus	231-247
9526000-2	1998	In AtT-20 cells transfected with rat cannabinoid receptor (CB1), the activation of an inwardly rectifying potassium current (Kir current) and depression of P/Q-type calcium channels by cannabinoids were prevented by stimulation of protein kinase C by 100 nM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	291-294	cannabinoid receptor 1	Rattus norvegicus	59-62
9526000-2	1998	In AtT-20 cells transfected with rat cannabinoid receptor (CB1), the activation of an inwardly rectifying potassium current (Kir current) and depression of P/Q-type calcium channels by cannabinoids were prevented by stimulation of protein kinase C by 100 nM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	291-294	protein kinase C, gamma	Rattus norvegicus	231-247
9535857-3	1998	In several cell types, phorbol 12-myristate 13-acetate (PMA) acutely inhibits NHE3 activity by changes in Vmax, but the mechanism of this inhibition is unknown.	Tetradecanoylphorbol Acetate	23-54	solute carrier family 9 member A3	Homo sapiens	78-82
9535857-3	1998	In several cell types, phorbol 12-myristate 13-acetate (PMA) acutely inhibits NHE3 activity by changes in Vmax, but the mechanism of this inhibition is unknown.	Tetradecanoylphorbol Acetate	56-59	solute carrier family 9 member A3	Homo sapiens	78-82
9563852-3	1998	We report that Ax 1 synthesis occurs upon phorbol 12-myristate 13-acetate (PMA) treatment of A 549 cells and its appearance is correlated with the presence of dipeptidyl peptidase IV, or CD26, a marker of epithelial cell differentiation.	Tetradecanoylphorbol Acetate	42-73	annexin A1	Homo sapiens	15-19
9563852-3	1998	We report that Ax 1 synthesis occurs upon phorbol 12-myristate 13-acetate (PMA) treatment of A 549 cells and its appearance is correlated with the presence of dipeptidyl peptidase IV, or CD26, a marker of epithelial cell differentiation.	Tetradecanoylphorbol Acetate	75-78	annexin A1	Homo sapiens	15-19
9563852-4	1998	In addition, using transfection experiments and site-directed mutagenesis with the Ax 1 promoter coupled to a reporter gene, we report that a unique region of the Ax 1 promoter confers the response of the reporter gene to PMA and dexamethasone.	Tetradecanoylphorbol Acetate	222-225	annexin A1	Homo sapiens	83-87
9563852-4	1998	In addition, using transfection experiments and site-directed mutagenesis with the Ax 1 promoter coupled to a reporter gene, we report that a unique region of the Ax 1 promoter confers the response of the reporter gene to PMA and dexamethasone.	Tetradecanoylphorbol Acetate	222-225	annexin A1	Homo sapiens	163-167
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	15-51	matrix metallopeptidase 9	Homo sapiens	117-122
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	15-51	matrix metallopeptidase 9	Homo sapiens	207-212
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	53-56	matrix metallopeptidase 9	Homo sapiens	117-122
9568638-6	1998	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific.	Tetradecanoylphorbol Acetate	53-56	matrix metallopeptidase 9	Homo sapiens	207-212
9568638-8	1998	The secretion of immunoreactive PAI-1 was considerably elevated (&gt; 20-fold) in TPA-treated MCF7/LCC1 cells, whereas the TPA-dependent level of 92-kDa MMP-9 was only approximately 2-fold higher in MCF7/LCC1 cells than in MCF-7 cells.	Tetradecanoylphorbol Acetate	82-85	C-C motif chemokine ligand 16	Homo sapiens	99-103
9568638-8	1998	The secretion of immunoreactive PAI-1 was considerably elevated (&gt; 20-fold) in TPA-treated MCF7/LCC1 cells, whereas the TPA-dependent level of 92-kDa MMP-9 was only approximately 2-fold higher in MCF7/LCC1 cells than in MCF-7 cells.	Tetradecanoylphorbol Acetate	82-85	C-C motif chemokine ligand 16	Homo sapiens	204-208
9568638-8	1998	The secretion of immunoreactive PAI-1 was considerably elevated (&gt; 20-fold) in TPA-treated MCF7/LCC1 cells, whereas the TPA-dependent level of 92-kDa MMP-9 was only approximately 2-fold higher in MCF7/LCC1 cells than in MCF-7 cells.	Tetradecanoylphorbol Acetate	123-126	matrix metallopeptidase 9	Homo sapiens	153-158
9568638-8	1998	The secretion of immunoreactive PAI-1 was considerably elevated (&gt; 20-fold) in TPA-treated MCF7/LCC1 cells, whereas the TPA-dependent level of 92-kDa MMP-9 was only approximately 2-fold higher in MCF7/LCC1 cells than in MCF-7 cells.	Tetradecanoylphorbol Acetate	123-126	C-C motif chemokine ligand 16	Homo sapiens	204-208
9568638-9	1998	In both cell lines treatment with TPA was associated with an increase (approximately 10-fold) in in vitro migration, which in the MCF7/LCC1 cells was significantly attenuated by a reconstituted basement membrane extract (Matrigel).	Tetradecanoylphorbol Acetate	34-37	C-C motif chemokine ligand 16	Homo sapiens	135-139
9520415-5	1998	Three motifs, homologous to the binding sites of NF-kappaB, SP-1, and AP-1 proteins, contribute to induction of the MMP9 promoter by 12-O-tetradecanoyl-phorbol-13-acetate and tumor necrosis factor alpha.	Tetradecanoylphorbol Acetate	133-170	matrix metallopeptidase 9	Homo sapiens	116-120
9524250-7	1998	TPA inducibility of this DH region was seen by the CAT reporter assay and appeared to be direction-dependent suggesting a functional cooperation between PEA3/TTCA and TRE.	Tetradecanoylphorbol Acetate	0-3	ETS variant transcription factor 4	Homo sapiens	153-157
9478937-5	1998	Functional activation of the JNKK/SEK1-JNK/SAPK-c-Jun cascade (where JNKK/SEK1 is JNK kinase/SAPK kinase) was demonstrated by activation of a 12-O-tetradecanoylphorbol-13-acetate response element (TRE) reporter construct in a c-Jun dependent fashion.	Tetradecanoylphorbol Acetate	142-178	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	226-231
9487139-3	1998	Phosphorylation of rabbit OSBP stably overexpressed in CHO-K1 cells was altered by staurosporine and okadaic acid, while other protein kinase activators and inhibitors such as TPA, sphingosine and bis-indolylmaleimide were without affect.	Tetradecanoylphorbol Acetate	176-179	oxysterol-binding protein 1	Oryctolagus cuniculus	26-30
9486138-3	1998	Platelet-derived growth factor-BB (PDGF-BB), endothelin-1 (ET-1), and phorbol 12-myristate 13-acetate (PMA) induced a dose-dependent expression of ets-1 mRNA.	Tetradecanoylphorbol Acetate	70-101	ETS proto-oncogene 1, transcription factor	Rattus norvegicus	147-152
9445389-8	1998	These results demonstrate that activation of the protein kinase C pathway by PMA results in an early up-regulation of H3.3B gene expression via the CRE/TRE element.	Tetradecanoylphorbol Acetate	77-80	tRNA-Glu (anticodon TTC) 3-1	Homo sapiens	152-155
9472806-9	1998	In vitro activation of normal eosinophils with phorbol 12-myristate 13-acetate upregulated CD9 and EG2 expression but failed to induce the CD25 antigen, suggesting that selective activating stimuli may be required.	Tetradecanoylphorbol Acetate	47-78	CD9 molecule	Homo sapiens	91-94
9557948-8	1998	Combined with PMA, PGE2 can overcome the decrease induced by PMA of the CD3 expression and partially reduced the disappearance of the CD4 molecule.	Tetradecanoylphorbol Acetate	14-17	CD4 antigen	Mus musculus	134-137
9433911-5	1998	A similar defect of CD8+ cells of HIV+ individuals was also seen with H2O2 levels stimulated with PMA in the presence of a catalase inhibitor.	Tetradecanoylphorbol Acetate	98-101	CD8a molecule	Homo sapiens	20-23
9419349-5	1998	ITF also decreased activation of ERK activity induced by either transforming growth factor-alpha, which links extracellular stimuli to the Ras/Raf/MEK/ERK pathway via the epidermal growth factor receptor, or phorbol 12-myristate 13-acetate, which activates Raf through protein kinase C. ITF-induced inhibition of ERK activity was blocked by an inhibitor of tyrosine and dual-specific phosphatases, sodium orthovanadate.	Tetradecanoylphorbol Acetate	208-239	trefoil factor 3	Rattus norvegicus	0-3
9468299-7	1998	Suramin-activated PKCmu behaves like that activated by phosphatidylserine and the phorbol ester TPA regarding autophosphorylation and differential inhibition by the PKC inhibitors Go 6976 and Go 6983.	Tetradecanoylphorbol Acetate	96-99	protein kinase D1	Homo sapiens	18-23
9468299-7	1998	Suramin-activated PKCmu behaves like that activated by phosphatidylserine and the phorbol ester TPA regarding autophosphorylation and differential inhibition by the PKC inhibitors Go 6976 and Go 6983.	Tetradecanoylphorbol Acetate	96-99	protein kinase C zeta	Homo sapiens	18-21
9468299-8	1998	In the presence of activating cofactors, such as phosphatidylserine and TPA or cholesterol sulfate (for PKCzeta), the activity of the aPKCzeta is further stimulated, PKCmu is not significantly affected, and the cPKCs and the nPKCdelta are strongly inhibited by suramin.	Tetradecanoylphorbol Acetate	72-75	protein kinase C zeta	Homo sapiens	104-111
9468299-8	1998	In the presence of activating cofactors, such as phosphatidylserine and TPA or cholesterol sulfate (for PKCzeta), the activity of the aPKCzeta is further stimulated, PKCmu is not significantly affected, and the cPKCs and the nPKCdelta are strongly inhibited by suramin.	Tetradecanoylphorbol Acetate	72-75	protein kinase D1	Homo sapiens	166-171
9709308-4	1998	The HHV-8 vIL-6, vDHFR, vTS, and vBcl-2 proteins have all been shown to be active in a variety of appropriate functional assays, and transcripts from vIL-6, vMIP-1B, vIE1-A, vIE1-B, and vDHFR genes are all expressed as abundant single messenger RNA species after butyrate or phorbol ester (TPA) induction of the lytic cycle in HHV8-positive BCBL cell lines.	Tetradecanoylphorbol Acetate	290-293	K2	Human gammaherpesvirus 8	10-15
9870716-1	1998	Calphostin C, a secondary metabolite of the fungus Cladosporium cladosporioides, is generally used as a specific inhibitor of protein kinase C. It is known that 12-O-tetradecanoyl-13-phorbol acetate (TPA), a protein kinase C activator, induces expression of mRNA for amphiregulin (AR), a member of EGF-related polypeptides, in mammalian epithelial cells.	Tetradecanoylphorbol Acetate	200-203	amphiregulin	Homo sapiens	267-279
9870716-1	1998	Calphostin C, a secondary metabolite of the fungus Cladosporium cladosporioides, is generally used as a specific inhibitor of protein kinase C. It is known that 12-O-tetradecanoyl-13-phorbol acetate (TPA), a protein kinase C activator, induces expression of mRNA for amphiregulin (AR), a member of EGF-related polypeptides, in mammalian epithelial cells.	Tetradecanoylphorbol Acetate	200-203	amphiregulin	Homo sapiens	281-283
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Tetradecanoylphorbol Acetate	113-138	colony stimulating factor 1 (macrophage)	Mus musculus	196-201
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Tetradecanoylphorbol Acetate	140-143	colony stimulating factor 1 (macrophage)	Mus musculus	196-201
9704334-10	1998	Phorbol 12-myristate 13-acetate (PMA, 2 or 5 nM) protected CCE cells against apoptosis induced by the introduction of TGF-beta 1 and withdrawal of aFGF, bFGF or VEGF, while H7 (50 microM), but not HA1004 (50 microM), abrogated the protective effect of PMA on CCE apoptosis.	Tetradecanoylphorbol Acetate	0-31	vascular endothelial growth factor A	Mus musculus	161-165
9388261-8	1997	The binding of (p65)2 and/or c-Rel/p65 to the A2 probe was also detected from 12-o-tetradecanoylphorbol 13-acetate-stimulated HeLa, HOS, and A172 cells in which expression of MCP-1 mRNA was elevated.	Tetradecanoylphorbol Acetate	78-114	REL proto-oncogene, NF-kB subunit	Homo sapiens	29-34
9388271-8	1997	Both ErbB2 and paxillin also exhibit reduced migration on SDS-polyacrylamide gel electrophoresis following PMA treatment, suggesting that they are also phosphorylated on serine/threonine residues.	Tetradecanoylphorbol Acetate	107-110	erb-b2 receptor tyrosine kinase 2	Rattus norvegicus	5-10
9388272-5	1997	272, 31172-31181), we demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment of Fao cells induces tyrosine phosphorylation of several proteins including ErbB2 and ErbB3.	Tetradecanoylphorbol Acetate	40-71	erb-b2 receptor tyrosine kinase 2	Rattus norvegicus	164-169
9461041-0	1997	A variant of the HL-60 cell line expressing a high level of PTP1C exhibits increased susceptibility to differentiation by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	122-153	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	60-65
9461041-4	1997	Furthermore, antisense PTP1C oligonucleotides decreased the PMA-induced adherence of HL-60/MCSFR4D2 cells.	Tetradecanoylphorbol Acetate	60-63	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	23-28
9435584-9	1997	PKC downregulation with 1 microM phorbol 12-myristate 13-acetate had the same selective antiproliferative effect on immature fibroblasts as GF-109203X and Go-6976.	Tetradecanoylphorbol Acetate	33-64	protein kinase C alpha	Bos taurus	0-3
9435584-10	1997	The protein levels of PKC-alpha and -beta II, but not of PKC-beta I, were completely degraded in response to phorbol 12-myristate 13-acetate pretreatment.	Tetradecanoylphorbol Acetate	109-140	protein kinase C alpha	Bos taurus	22-44
9435679-6	1997	cPLA2 activity stimulated by phorbol ester [phorbol 12-myristate 13-acetate (PMA)] displayed a similar degree of activation and was associated with an increase in serine phosphorylation identical to that caused by BK.	Tetradecanoylphorbol Acetate	44-75	cytosolic phospholipase A2	Oryctolagus cuniculus	0-5
9435679-6	1997	cPLA2 activity stimulated by phorbol ester [phorbol 12-myristate 13-acetate (PMA)] displayed a similar degree of activation and was associated with an increase in serine phosphorylation identical to that caused by BK.	Tetradecanoylphorbol Acetate	77-80	cytosolic phospholipase A2	Oryctolagus cuniculus	0-5
9430371-8	1997	c-fos mRNA expression induced by 4-beta-phorbol-12-myristate-13-acetate, an activator of protein kinase C, was insensitive to lovastatin treatment.	Tetradecanoylphorbol Acetate	33-71	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
9371732-10	1997	Acute treatment of ASM cells with PMA (a direct activator of PKC) also stimulated the MAPK-dependent phosphorylation of cPLA2.	Tetradecanoylphorbol Acetate	34-37	phospholipase A2 group IVA	Homo sapiens	120-125
10092879-2	1999	Injection into rats of 4 beta-phorbol 12-myristate 13-acetate, a known activator of PKC, caused a rapid and marked increase in PKC activity (+325% at 10 min) in the GE fraction, along with an increase in the abundance of the PKC alpha-isoform as seen on Western immunoblots.	Tetradecanoylphorbol Acetate	23-61	protein kinase C, alpha	Rattus norvegicus	84-87
10092879-2	1999	Injection into rats of 4 beta-phorbol 12-myristate 13-acetate, a known activator of PKC, caused a rapid and marked increase in PKC activity (+325% at 10 min) in the GE fraction, along with an increase in the abundance of the PKC alpha-isoform as seen on Western immunoblots.	Tetradecanoylphorbol Acetate	23-61	protein kinase C, alpha	Rattus norvegicus	127-130
10092879-2	1999	Injection into rats of 4 beta-phorbol 12-myristate 13-acetate, a known activator of PKC, caused a rapid and marked increase in PKC activity (+325% at 10 min) in the GE fraction, along with an increase in the abundance of the PKC alpha-isoform as seen on Western immunoblots.	Tetradecanoylphorbol Acetate	23-61	protein kinase C, alpha	Rattus norvegicus	225-234
10092879-5	1999	In contrast, addition of purified PKC increased (twofold) PDE activity in GE fractions from control rats but affected only slightly the activity in GE fractions from 4 beta-phorbol 12-myristate 13-acetate-treated rats.	Tetradecanoylphorbol Acetate	168-204	protein kinase C, alpha	Rattus norvegicus	34-37
9927621-10	1999	The potent PKC inhibitor bisindolylmaleimide I dose dependently inhibited ERK and JNK activation by TPA, but not NE.	Tetradecanoylphorbol Acetate	100-103	protein kinase C, gamma	Rattus norvegicus	11-14
9873009-2	1999	In this study, we show that the secretion of matrix metalloproteinase-9 (MMP-9) from HT 1080 human fibrosarcoma cells was stimulated by phorbol 12-myristate 13-acetate in a time- and dose-dependent manner that involved protein kinase C. The phorbol ester also increased PLD activity in the cells.	Tetradecanoylphorbol Acetate	136-167	matrix metallopeptidase 9	Homo sapiens	45-71
9873009-2	1999	In this study, we show that the secretion of matrix metalloproteinase-9 (MMP-9) from HT 1080 human fibrosarcoma cells was stimulated by phorbol 12-myristate 13-acetate in a time- and dose-dependent manner that involved protein kinase C. The phorbol ester also increased PLD activity in the cells.	Tetradecanoylphorbol Acetate	136-167	matrix metallopeptidase 9	Homo sapiens	73-78
10189500-5	1999	In particular, levels of tissue plasminogen activator activity (TPA), and fibrin and fibrinogen degradation products (FDP) all decreased.	Tetradecanoylphorbol Acetate	64-67	chromosome 20 open reading frame 181	Homo sapiens	25-53
9888864-6	1999	This region of the PAI-1 promoter was previously found to contain a tetradecanoyl phorbol acetate-response element (TRE; between -58 and -50) necessary for PMA responsiveness and with a high affinity for c-Jun homodimers.	Tetradecanoylphorbol Acetate	68-97	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	204-209
9886389-5	1999	Similar to PMA treatment, which abolished both CXCR4 receptor expression and the chemotactic response of Jurkat cells to SDF-1, anti-CD3 Ab treatment reduced cell surface expression of CXCR4 to 65% of the control value, an effect that was blocked by protein kinase C inhibitors.	Tetradecanoylphorbol Acetate	11-14	C-X-C motif chemokine receptor 4	Homo sapiens	47-52
9886389-5	1999	Similar to PMA treatment, which abolished both CXCR4 receptor expression and the chemotactic response of Jurkat cells to SDF-1, anti-CD3 Ab treatment reduced cell surface expression of CXCR4 to 65% of the control value, an effect that was blocked by protein kinase C inhibitors.	Tetradecanoylphorbol Acetate	11-14	C-X-C motif chemokine receptor 4	Homo sapiens	185-190
9892016-3	1999	By transient transfection of the GH3 cell line, we demonstrate that activation of the PKC system with the phorbol ester, phorbol 12-myristate 13-acetate (PMA), increases activity of region -207/+5 of the rat LHbeta gene promoter (approximately 2-fold) and markedly augments SF-1-induced stimulation (95-fold in the presence of both factors vs. 13-fold for SF-1 alone).	Tetradecanoylphorbol Acetate	121-152	nuclear receptor subfamily 5, group A, member 1	Rattus norvegicus	274-278
9892016-3	1999	By transient transfection of the GH3 cell line, we demonstrate that activation of the PKC system with the phorbol ester, phorbol 12-myristate 13-acetate (PMA), increases activity of region -207/+5 of the rat LHbeta gene promoter (approximately 2-fold) and markedly augments SF-1-induced stimulation (95-fold in the presence of both factors vs. 13-fold for SF-1 alone).	Tetradecanoylphorbol Acetate	121-152	nuclear receptor subfamily 5, group A, member 1	Rattus norvegicus	356-360
10579204-5	1999	Electrophoretic mobility shift assays and supershift assays revealed that c-Fos-containing activator protein- complexes preferentially bound the metallothionein phorbol-12-myristate-13-acetate response element sequence-containing oligonucleotides.	Tetradecanoylphorbol Acetate	161-192	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-79
9883882-1	1998	We studied the regulation of the beta-galactoside alpha2,6-sialyltransferase (hST6Gal I) gene during HL-60 cell differentiation induced with dimethyl sulfoxide (DMSO), all transretinoic acid (ATRA), and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	203-228	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	78-87
9883882-1	1998	We studied the regulation of the beta-galactoside alpha2,6-sialyltransferase (hST6Gal I) gene during HL-60 cell differentiation induced with dimethyl sulfoxide (DMSO), all transretinoic acid (ATRA), and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	230-233	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	78-87
10381133-2	1998	Application of TPA to mouse skin induces oxidative stress, as evidenced by numerous biochemical responses, including significant generation of H2O2 and enhanced levels of myeloperoxidase and oxidized glutathione reductase activities and decreases in glutathione levels and superoxide dismutase activity.	Tetradecanoylphorbol Acetate	15-18	myeloperoxidase	Mus musculus	171-186
9829997-1	1998	The inhibition of gamma-aminobutyric acid (GABA)-gated chloride currents by the protein kinase C (PKC) activator 4beta-phorbol 12-myristate 13-acetate (PMA) was investigated using recombinant human GABAA receptors expressed in Xenopus oocytes.	Tetradecanoylphorbol Acetate	113-150	GABA(A) receptor-associated protein L homeolog	Xenopus laevis	198-203
9829997-1	1998	The inhibition of gamma-aminobutyric acid (GABA)-gated chloride currents by the protein kinase C (PKC) activator 4beta-phorbol 12-myristate 13-acetate (PMA) was investigated using recombinant human GABAA receptors expressed in Xenopus oocytes.	Tetradecanoylphorbol Acetate	152-155	GABA(A) receptor-associated protein L homeolog	Xenopus laevis	198-203
9829997-11	1998	It is concluded that, in Xenopus oocytes, PMA induces an internalization of the GABAA receptor through PKC-mediated phosphorylation of an unidentified protein(s) and that this contributes to the decrease in electrophysiological responses to GABA following PKC activation.	Tetradecanoylphorbol Acetate	42-45	GABA(A) receptor-associated protein L homeolog	Xenopus laevis	80-85
9846968-8	1998	Injection of neutralizing antibodies to GM-CSF after TPA application reduced the number of papillomas in Tg.AC mice.	Tetradecanoylphorbol Acetate	53-56	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	40-46
9885901-5	1998	By contrast, phorbol myristate acetate (PMA) and/or ionomycin-induced apoptosis had much slower kinetics, were preceded by an early increase of NF-kappaB/RelA-p50, AP-1 and NUR-77 activities, and were insensitive to proteasome inhibition.	Tetradecanoylphorbol Acetate	13-38	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	164-168
9885901-5	1998	By contrast, phorbol myristate acetate (PMA) and/or ionomycin-induced apoptosis had much slower kinetics, were preceded by an early increase of NF-kappaB/RelA-p50, AP-1 and NUR-77 activities, and were insensitive to proteasome inhibition.	Tetradecanoylphorbol Acetate	40-43	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	164-168
9815227-2	1998	Incubation with 20-100 ng/mL IL-10 for 2-3 days decreased the fungicidal activity of monocytes against serum-opsonized C. albicans blastoconidia (P&lt;/=.04), reduced their capacity to damage unopsonized hyphae (P&lt;/=.006), and suppressed superoxide anion production in response to phorbol myristate acetate (P=.019) and N-FMLP (P=.04) but not to serum-opsonized blastoconidia.	Tetradecanoylphorbol Acetate	284-309	interleukin 10	Homo sapiens	29-34
9862447-4	1998	Cytokine-induced activation of neutral SMase was inhibited by stimulation of protein kinase C (PKC) by the phorbol ester TPA which caused a reduction of ceramide back to control levels.	Tetradecanoylphorbol Acetate	121-124	protein kinase C, alpha	Rattus norvegicus	95-98
9862447-5	1998	This inhibitory effect of TPA was reversed by the specific PKC-inhibitor Ro-318220.	Tetradecanoylphorbol Acetate	26-29	protein kinase C, alpha	Rattus norvegicus	59-62
9862447-6	1998	Long-term incubation (24 h) of mesangial cells with TPA, which downregulates PKC-alpha, -delta, and -epsilon isoenzymes, resulted in a recovery of IL-1beta-stimulated neutral SMase activity as well as ceramide formation.	Tetradecanoylphorbol Acetate	52-55	protein kinase C, alpha	Rattus norvegicus	77-108
9815052-7	1998	12-O-tetradecanoylphorbol 13-acetate (TPA) also reduced the magnitude of the potentiation of amylase release caused by VIP plus CCK-8 or CCh, although TPA itself decreased neither VIP-stimulated adenylyl cyclase activity nor intracellular cAMP accumulation.	Tetradecanoylphorbol Acetate	0-36	cholecystokinin	Rattus norvegicus	128-131
9815052-7	1998	12-O-tetradecanoylphorbol 13-acetate (TPA) also reduced the magnitude of the potentiation of amylase release caused by VIP plus CCK-8 or CCh, although TPA itself decreased neither VIP-stimulated adenylyl cyclase activity nor intracellular cAMP accumulation.	Tetradecanoylphorbol Acetate	38-41	cholecystokinin	Rattus norvegicus	128-131
9824507-3	1998	Cross-linking GPI-anchored molecules, including CD52, on the surface of T lymphocytes in the presence of phorbol 12-myristate 13-acetate or anti-CD3, results in cellular activation.	Tetradecanoylphorbol Acetate	105-136	CD52 molecule	Homo sapiens	48-52
9794432-4	1998	Dexamethasone down-regulated the NADPH oxidase system of cytokine-differentiated THP-1 cells as assessed by an inhibition on the PMA-stimulated superoxide release, cytochrome b558 content, and expression of the gp91-phox and p47-phox genes.	Tetradecanoylphorbol Acetate	129-132	neutrophil cytosolic factor 1	Homo sapiens	225-233
9794433-6	1998	4) In PMA-stimulated B cells from an X91+ CGD patient in which p22phox was normally expressed and gp91phox was present but lacked five amino acids, translocation of p47phox to the membranes was unaffected, but p67phox and p40phox were poorly translocated, and the production of O2- was greatly reduced with respect to that by normal B cells.	Tetradecanoylphorbol Acetate	6-9	cytochrome b-245 beta chain	Homo sapiens	98-106
9794433-6	1998	4) In PMA-stimulated B cells from an X91+ CGD patient in which p22phox was normally expressed and gp91phox was present but lacked five amino acids, translocation of p47phox to the membranes was unaffected, but p67phox and p40phox were poorly translocated, and the production of O2- was greatly reduced with respect to that by normal B cells.	Tetradecanoylphorbol Acetate	6-9	neutrophil cytosolic factor 1	Homo sapiens	165-172
9821665-5	1998	These results suggest that the inhibition of PMA-induced rat neutrophil aggregation by magnolol is probably attributable, at least in part, to the direct suppression of PKC activity through blockade of the regulatory region of PKC.	Tetradecanoylphorbol Acetate	45-48	protein kinase C, gamma	Rattus norvegicus	169-172
9821665-5	1998	These results suggest that the inhibition of PMA-induced rat neutrophil aggregation by magnolol is probably attributable, at least in part, to the direct suppression of PKC activity through blockade of the regulatory region of PKC.	Tetradecanoylphorbol Acetate	45-48	protein kinase C, gamma	Rattus norvegicus	227-230
9788660-8	1998	PMNs in washed whole blood were then analyzed for phorbol myristate acetate (PMA)-stimulated CD11b, CD35, and CD16 expressions and production of reactive oxygen intermediates (ROI), as well as phagocytosis with/without anti-CD11b antibody.	Tetradecanoylphorbol Acetate	50-75	integrin subunit alpha M	Homo sapiens	93-98
9788660-8	1998	PMNs in washed whole blood were then analyzed for phorbol myristate acetate (PMA)-stimulated CD11b, CD35, and CD16 expressions and production of reactive oxygen intermediates (ROI), as well as phagocytosis with/without anti-CD11b antibody.	Tetradecanoylphorbol Acetate	50-75	Fc gamma receptor IIIa	Homo sapiens	110-114
9788660-8	1998	PMNs in washed whole blood were then analyzed for phorbol myristate acetate (PMA)-stimulated CD11b, CD35, and CD16 expressions and production of reactive oxygen intermediates (ROI), as well as phagocytosis with/without anti-CD11b antibody.	Tetradecanoylphorbol Acetate	77-80	integrin subunit alpha M	Homo sapiens	93-98
9788660-8	1998	PMNs in washed whole blood were then analyzed for phorbol myristate acetate (PMA)-stimulated CD11b, CD35, and CD16 expressions and production of reactive oxygen intermediates (ROI), as well as phagocytosis with/without anti-CD11b antibody.	Tetradecanoylphorbol Acetate	77-80	Fc gamma receptor IIIa	Homo sapiens	110-114
9722539-6	1998	UTP, ionomycin, and phorbol ester (phorbol 12-myristate 13-acetate) increased MAP kinase activity and also promoted the tyrosine phosphorylation of RAFTK, the epidermal growth factor (EGF) receptor, SHC, and p120(cbl).	Tetradecanoylphorbol Acetate	35-66	epidermal growth factor receptor	Rattus norvegicus	159-197
9722539-9	1998	The similar effects of UTP, ionomycin, and phorbol 12-myristate 13-acetate (PMA) on these signaling proteins demonstrate that the two signaling molecules from phosphatidylinositol 4,5-bisphosphate hydrolysis ([Ca2+]i, from inositol 1,4,5-trisphosphate production, and diacylglycerol) can individually initiate the activation of MAP kinase in an EGF receptor-dependent manner.	Tetradecanoylphorbol Acetate	43-74	epidermal growth factor receptor	Rattus norvegicus	345-357
9722539-9	1998	The similar effects of UTP, ionomycin, and phorbol 12-myristate 13-acetate (PMA) on these signaling proteins demonstrate that the two signaling molecules from phosphatidylinositol 4,5-bisphosphate hydrolysis ([Ca2+]i, from inositol 1,4,5-trisphosphate production, and diacylglycerol) can individually initiate the activation of MAP kinase in an EGF receptor-dependent manner.	Tetradecanoylphorbol Acetate	76-79	epidermal growth factor receptor	Rattus norvegicus	345-357
9730948-5	1998	Both PGF and PMA had additive effects on FSK-dependent CFTR activity.	Tetradecanoylphorbol Acetate	13-16	cystic fibrosis transmembrane conductance regulator	Mus musculus	55-59
9768595-11	1998	The selective PKC inhibitors, bis-indolylmaleimide II and Ro-31-8220 inhibited the phorbol 12-myristate 13-acetate-mediated cPLA2 electrophoretic mobility shift, but not the IL-3-mediated shift, suggesting that the IL-3 effect is PKC independent.	Tetradecanoylphorbol Acetate	83-114	phospholipase A2 group IVA	Homo sapiens	124-129
9720718-4	1998	These double CD7 and myeloid antigen (CD13 and/or CD33) positive progenitors tend to lose their CD7 expression, while retaining their myeloid characteristics, after in vitro culture with the differentiation-inducing agent phorbol ester (TPA).	Tetradecanoylphorbol Acetate	237-240	CD7 molecule	Homo sapiens	13-16
9729434-8	1998	On the other hand, TPA-induced rantes expression was not superinduced by cycloheximide, suggesting a protein synthesis-dependent process.	Tetradecanoylphorbol Acetate	19-22	C-C motif chemokine ligand 5	Homo sapiens	31-37
9766008-0	1998	Role of Glut1 glucose transporter activation in stimulation of glucose transport by A231876 and TPA.	Tetradecanoylphorbol Acetate	96-99	solute carrier family 2 member 1	Homo sapiens	8-13
9716184-0	1998	v-Jun represses c-jun proto-oncogene expression in vivo through a 12-O-tetradecanoylphorbol-13-acetate-responsive element in the proximal gene promoter.	Tetradecanoylphorbol Acetate	66-102	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	16-21
9744550-12	1998	In contrast, genistein only exhibited a moderate inhibition of TPA-induced ornithine decarboxylase activity (P &gt; 0.05).	Tetradecanoylphorbol Acetate	63-66	ornithine decarboxylase, structural 1	Mus musculus	75-98
9849427-3	1998	Their effects on c-fos mRNA levels after induction by either epidermal growth factor (EGF) or the tumour promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) was measured in human breast cancer-derived MDA-MB-468 cells.	Tetradecanoylphorbol Acetate	129-165	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-22
9849427-3	1998	Their effects on c-fos mRNA levels after induction by either epidermal growth factor (EGF) or the tumour promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) was measured in human breast cancer-derived MDA-MB-468 cells.	Tetradecanoylphorbol Acetate	167-170	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-22
9849427-5	1998	In contrast, both genistein and equol at 100 mumol/l decreased TPA-induced c-fos levels, by 75 and 67%, respectively.	Tetradecanoylphorbol Acetate	63-66	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-80
9681449-4	1998	Studies with protein kinase inhibitors and phorbol 12-myristate 13-acetate showed that protein kinase C (PKC) is activated intracellularly.	Tetradecanoylphorbol Acetate	43-74	protein kinase C, alpha	Rattus norvegicus	105-108
9710256-8	1998	When cells were stimulated with phorbol 12-myristate 13-acetate or phorbol 12,13-diacetate, Ca2+ was released from these tubules.	Tetradecanoylphorbol Acetate	32-63	carbonic anhydrase 2	Homo sapiens	92-95
9353351-9	1997	The important contribution of the PKCepsilon catalytic domain to the growth of PKCdelta/epsilon-expressing cells was also evident in terms of a significantly increased saturation density in the presence of PMA, their formation of foci upon PMA treatment, and the induction of anchorage-independent growth.	Tetradecanoylphorbol Acetate	206-209	protein kinase C, delta	Mus musculus	79-87
9374631-9	1997	The effect of CCK in activating Rafs was at least partially mimicked by stimulation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	107-143	cholecystokinin	Rattus norvegicus	14-17
9671751-2	1998	We have used stable transfection assays to show that activation of the mitogen-activated protein (MAP) kinase pathway by low concentrations of the phorbol ester phorbol 12-tetradecanoate 13-acetate (TPA) induces enhancer activity of the LCR subregion HS2, but not HS3.	Tetradecanoylphorbol Acetate	161-197	spectrin alpha, erythrocytic 1	Homo sapiens	264-267
3827822-2	1986	Phorbol myristate acetate (PMA)-stimulated human monocyte-like cells (U-937) were found to synthesize the third component of complement (C3), as shown by enzyme-linked immunosorbent assay and immunoprecipitation from [35S]methionine-labelled culture supernatants.	Tetradecanoylphorbol Acetate	0-25	complement C3	Homo sapiens	125-139
9671751-2	1998	We have used stable transfection assays to show that activation of the mitogen-activated protein (MAP) kinase pathway by low concentrations of the phorbol ester phorbol 12-tetradecanoate 13-acetate (TPA) induces enhancer activity of the LCR subregion HS2, but not HS3.	Tetradecanoylphorbol Acetate	199-202	spectrin alpha, erythrocytic 1	Homo sapiens	264-267
9719465-6	1998	(3) Pheophytin a and b from green tea showed inhibitory effects against early induction of ornithine decarboxylase (ODC) in BALB/c mouse skin fibroblasts caused by TPA.	Tetradecanoylphorbol Acetate	164-167	ornithine decarboxylase, structural 1	Mus musculus	91-114
9719465-6	1998	(3) Pheophytin a and b from green tea showed inhibitory effects against early induction of ornithine decarboxylase (ODC) in BALB/c mouse skin fibroblasts caused by TPA.	Tetradecanoylphorbol Acetate	164-167	ornithine decarboxylase, structural 1	Mus musculus	116-119
9667501-4	1998	Inhibition of PMA-induced ICAM-1 and VCAM-1 expression as well as PMA-induced adhesion of Jurkat T-cells to ECV cells by alpha-lipoate was dose dependent (50-250 microM).	Tetradecanoylphorbol Acetate	14-17	intercellular adhesion molecule 1	Homo sapiens	26-32
9351440-6	1997	The deletion analysis revealed that the c-fos serum response element (SRE) and the 12-O-tetradecanoylphorbol-13-acetate response element (TRE) mainly account for c-fos luciferase expression by RhoA Val14.	Tetradecanoylphorbol Acetate	83-119	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	162-167
9348195-4	1997	Both 1,25-(OH)2D3 and TPA independently up-regulated the vitamin D receptor, p21, and the hypophosphorylated form of retinoblastoma (Rb) protein.	Tetradecanoylphorbol Acetate	22-25	vitamin D receptor	Homo sapiens	57-75
9348199-4	1997	We also found that treatment of L6 myotubes with 5 microM tetradecanoyl phorbol-13-acetate (TPA) for 24 h led to 80-100% losses of all DAG-dependent PKCs (alpha, beta1, beta2, delta, epsilon) and TPA-stimulated glucose transport (2-deoxyglucose uptake); in contrast, there was full retention of PKC-zeta, as well as insulin-stimulated glucose transport and translocation of GLUT4 and GLUT1 to the plasma membrane.	Tetradecanoylphorbol Acetate	92-95	protein kinase C zeta	Homo sapiens	295-303
9348199-6	1997	Of further interest, TPA acutely activated membrane-associated PI 3-kinase in L6 myotubes, and acute effects of TPA on glucose transport were inhibited, not only by the PKC inhibitor, LY379196, but also by both wortmannin and LY294002; this suggested that DAG-sensitive PKCs activate glucose transport through cross-talk with phosphatidylinositol (PI) 3-kinase, rather than directly through PKC.	Tetradecanoylphorbol Acetate	21-24	protein kinase C, beta	Rattus norvegicus	270-273
9348199-6	1997	Of further interest, TPA acutely activated membrane-associated PI 3-kinase in L6 myotubes, and acute effects of TPA on glucose transport were inhibited, not only by the PKC inhibitor, LY379196, but also by both wortmannin and LY294002; this suggested that DAG-sensitive PKCs activate glucose transport through cross-talk with phosphatidylinositol (PI) 3-kinase, rather than directly through PKC.	Tetradecanoylphorbol Acetate	112-115	protein kinase C, beta	Rattus norvegicus	169-172
3827822-2	1986	Phorbol myristate acetate (PMA)-stimulated human monocyte-like cells (U-937) were found to synthesize the third component of complement (C3), as shown by enzyme-linked immunosorbent assay and immunoprecipitation from [35S]methionine-labelled culture supernatants.	Tetradecanoylphorbol Acetate	27-30	complement C3	Homo sapiens	125-139
9348199-6	1997	Of further interest, TPA acutely activated membrane-associated PI 3-kinase in L6 myotubes, and acute effects of TPA on glucose transport were inhibited, not only by the PKC inhibitor, LY379196, but also by both wortmannin and LY294002; this suggested that DAG-sensitive PKCs activate glucose transport through cross-talk with phosphatidylinositol (PI) 3-kinase, rather than directly through PKC.	Tetradecanoylphorbol Acetate	112-115	protein kinase C, beta	Rattus norvegicus	270-273
9688860-2	1998	In SPOC1 cells, the mobilization of intracellular Ca2+ by ionomycin or the activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) stimulates mucin secretion in a fully additive fashion [L. H. Abdullah, J. D. Conway, J.	Tetradecanoylphorbol Acetate	115-146	solute carrier family 13 member 2	Rattus norvegicus	164-169
9688860-2	1998	In SPOC1 cells, the mobilization of intracellular Ca2+ by ionomycin or the activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) stimulates mucin secretion in a fully additive fashion [L. H. Abdullah, J. D. Conway, J.	Tetradecanoylphorbol Acetate	148-151	solute carrier family 13 member 2	Rattus norvegicus	164-169
9688860-13	1998	PMA, but not 4alpha-phorbol, increased mucin release at all Ca2+ activities tested: at 10 nM Ca2+ mucin release was 2.1-fold greater than control and at 4.7 microM Ca2+ mucin release was maximal (3.6-fold increase).	Tetradecanoylphorbol Acetate	0-3	solute carrier family 13 member 2	Rattus norvegicus	39-44
3093072-3	1986	Prolonged incubation with TPA allowed P- cells to regain their original appearance and resulted in growth inhibition; however, the extended presence of TPA produced in P+ cells persistent alterations in the distribution of actin, vinculin, and fibronectin.	Tetradecanoylphorbol Acetate	152-155	vinculin	Mus musculus	230-238
9688860-13	1998	PMA, but not 4alpha-phorbol, increased mucin release at all Ca2+ activities tested: at 10 nM Ca2+ mucin release was 2.1-fold greater than control and at 4.7 microM Ca2+ mucin release was maximal (3.6-fold increase).	Tetradecanoylphorbol Acetate	0-3	solute carrier family 13 member 2	Rattus norvegicus	98-103
9688860-13	1998	PMA, but not 4alpha-phorbol, increased mucin release at all Ca2+ activities tested: at 10 nM Ca2+ mucin release was 2.1-fold greater than control and at 4.7 microM Ca2+ mucin release was maximal (3.6-fold increase).	Tetradecanoylphorbol Acetate	0-3	solute carrier family 13 member 2	Rattus norvegicus	98-103
12386374-8	1997	These results suggest that CREB, rather than AP-1 proteins, are required for the CRE-mediated TPA activation of the beta-pol promoter.	Tetradecanoylphorbol Acetate	94-97	cAMP responsive element binding protein 1	Homo sapiens	27-31
9406065-7	1997	Upon stimulation of EL-4.IL-2 with phorbol-12-myristate-13-acetate, there were variable increases in interleukin-2 secretion (up to 2.4-fold for 10(6) Bifidobacterium Bf-1/ml) and interleukin-5 secretion (up to 4.6-fold for 10(8) B. adolescentis M101-4).	Tetradecanoylphorbol Acetate	35-66	epilepsy 4	Mus musculus	20-24
10091935-5	1998	TPA-treated B16F1 cells showed enhanced release of basic FGF (bFGF) and vascular endothelial growth factor (VEGF) and increased angiogenic capacity and lung colony formation in vivo.	Tetradecanoylphorbol Acetate	0-3	vascular endothelial growth factor A	Mus musculus	72-106
3021151-1	1986	The secretion of parathyroid hormone (PTH) is suppressed in bovine parathyroid cells by raised extracellular [Ca2+], and 12-0-tetradecanoyl-phorbol-13-acetate (TPA) stimulates the release of PTH from cells suppressed by high extracellular [Ca2+].	Tetradecanoylphorbol Acetate	160-163	parathyroid hormone	Bos taurus	17-36
10091935-5	1998	TPA-treated B16F1 cells showed enhanced release of basic FGF (bFGF) and vascular endothelial growth factor (VEGF) and increased angiogenic capacity and lung colony formation in vivo.	Tetradecanoylphorbol Acetate	0-3	vascular endothelial growth factor A	Mus musculus	108-112
9658185-2	1998	Exposure of the cells to 4beta-phorbol-12-myristate-13-acetate (PMA), an activator PKC, resulted in a down-regulation of both beta1AR binding sites and mRNA levels in a time- and concentration-dependent manner.	Tetradecanoylphorbol Acetate	25-62	protein kinase C, gamma	Rattus norvegicus	83-86
9658185-2	1998	Exposure of the cells to 4beta-phorbol-12-myristate-13-acetate (PMA), an activator PKC, resulted in a down-regulation of both beta1AR binding sites and mRNA levels in a time- and concentration-dependent manner.	Tetradecanoylphorbol Acetate	64-67	protein kinase C, gamma	Rattus norvegicus	83-86
9658188-1	1998	In whole-cell phosphorylation studies, recombinantly expressed human alpha2AAR displayed an increase in phosphorylation after short-term exposure to 100 nM phorbol 12-myristate-13-acetate (PMA) that was blocked by preincubation with a PKC inhibitor.	Tetradecanoylphorbol Acetate	156-187	adrenoceptor alpha 2A	Homo sapiens	69-78
9658188-1	1998	In whole-cell phosphorylation studies, recombinantly expressed human alpha2AAR displayed an increase in phosphorylation after short-term exposure to 100 nM phorbol 12-myristate-13-acetate (PMA) that was blocked by preincubation with a PKC inhibitor.	Tetradecanoylphorbol Acetate	189-192	adrenoceptor alpha 2A	Homo sapiens	69-78
31207793-9	1997	Upon stimulation of EL4.IL-2 cells with phorbol 12-myristate-13-acetate, IL-2 secretion increased up to 1.9-fold in the presence of 106 L. bulgaricus Lr 79 cells per ml whereas this cytokine decreased in the presence of 107 or 108 lactobacilli per ml.	Tetradecanoylphorbol Acetate	40-71	epilepsy 4	Mus musculus	20-23
3760584-5	1986	NADPH oxidase was activated by stimulation of macrophages with phorbol-myristate acetate and activity levels correlated with ability of intact cells to produce superoxide anion.	Tetradecanoylphorbol Acetate	63-88	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
9433916-3	1997	By treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), HL-60 cells were transformed to macrophage-like cells, which secreted PAF-AH into the culture medium time- and dose-dependently.	Tetradecanoylphorbol Acetate	18-54	phospholipase A2 group VII	Homo sapiens	132-138
9433916-3	1997	By treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), HL-60 cells were transformed to macrophage-like cells, which secreted PAF-AH into the culture medium time- and dose-dependently.	Tetradecanoylphorbol Acetate	56-59	phospholipase A2 group VII	Homo sapiens	132-138
9433916-5	1997	Among the substances examined, cortisol and TGF-beta suppressed PAF-AH secretion from TPA-stimulated HL-60 cells in a significant and dose-dependent way.	Tetradecanoylphorbol Acetate	86-89	phospholipase A2 group VII	Homo sapiens	64-70
9334224-7	1997	Our results provide an explanation for the inhibitory action of fMLP and phorbol 12-myristate 13-acetate on capacitative cation influx and reveal that upon physiological stimulation, Ca2+ entry into neutrophils is restricted by the depolarization accompanying O-2 production.	Tetradecanoylphorbol Acetate	73-104	immunoglobulin kappa variable 1D-39	Homo sapiens	260-263
9658188-5	1998	The desensitization of this agonist response was not caused by PKC-mediated augmentation of G protein-coupled receptor kinase activity, because PMA-promoted desensitization of a mutated alpha2AAR that lacked G protein-coupled receptor kinase phosphorylation sites was identical to that of wild-type alpha2AAR.	Tetradecanoylphorbol Acetate	144-147	alpha-2A adrenergic receptor	Cricetulus griseus	186-195
9658188-5	1998	The desensitization of this agonist response was not caused by PKC-mediated augmentation of G protein-coupled receptor kinase activity, because PMA-promoted desensitization of a mutated alpha2AAR that lacked G protein-coupled receptor kinase phosphorylation sites was identical to that of wild-type alpha2AAR.	Tetradecanoylphorbol Acetate	144-147	alpha-2A adrenergic receptor	Cricetulus griseus	299-308
9632690-8	1998	These hydrophobic residues appeared to be required for the binding of 14-3-3zeta to distinct activation states of Raf-1 because mutations V176D, L216D, L220D, and L227D reduced the interaction of 14-3-3zeta with Raf-1 from both phorbol 12-myristate 13-acetate-stimulated and unstimulated Jurkat T cells.	Tetradecanoylphorbol Acetate	228-259	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	70-80
9632690-8	1998	These hydrophobic residues appeared to be required for the binding of 14-3-3zeta to distinct activation states of Raf-1 because mutations V176D, L216D, L220D, and L227D reduced the interaction of 14-3-3zeta with Raf-1 from both phorbol 12-myristate 13-acetate-stimulated and unstimulated Jurkat T cells.	Tetradecanoylphorbol Acetate	228-259	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	196-206
9642110-3	1998	We have previously shown that moderate stimulation of CD4(+)CD8(+) thymocytes with a combination of the calcium ionophore ionomycin and phorbol myristate acetate mimics positive selection events including downregulation of CD8 expression.	Tetradecanoylphorbol Acetate	136-161	CD8a molecule	Homo sapiens	60-63
3733713-6	1986	Similarly, pretreatment with PMA abolished the ability of additional PMA to increase ornithine decarboxylase mRNA levels but did not prevent the increases in these mRNA levels caused by FGF or serum.	Tetradecanoylphorbol Acetate	29-32	ornithine decarboxylase, structural 1	Mus musculus	85-108
9642110-3	1998	We have previously shown that moderate stimulation of CD4(+)CD8(+) thymocytes with a combination of the calcium ionophore ionomycin and phorbol myristate acetate mimics positive selection events including downregulation of CD8 expression.	Tetradecanoylphorbol Acetate	136-161	CD8a molecule	Homo sapiens	223-226
9614208-5	1998	The response of prolactin mRNA to TGF-beta2 was inhibited by preincubation of cells with phorbol-12-myristate-13-acetate, which down-regulated protein kinase C (PKC).	Tetradecanoylphorbol Acetate	89-120	protein kinase C, gamma	Rattus norvegicus	143-159
9322938-6	1997	Treatment of the microsome-enriched fraction with crude rat brain PKC in the presence of phorbol 12-myristate 13-acetate (TPA) or CaCl2 abolished the specific [125I]melatonin binding.	Tetradecanoylphorbol Acetate	89-120	protein kinase C, gamma	Rattus norvegicus	66-69
9322938-6	1997	Treatment of the microsome-enriched fraction with crude rat brain PKC in the presence of phorbol 12-myristate 13-acetate (TPA) or CaCl2 abolished the specific [125I]melatonin binding.	Tetradecanoylphorbol Acetate	122-125	protein kinase C, gamma	Rattus norvegicus	66-69
3460639-2	1986	HL60 cells were shown to produce cathepsin B in response to treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	75-111	cathepsin B	Homo sapiens	33-44
9364213-6	1997	Because the level of the transcription factor activator protein 1 (AP-1) has been shown to be critical for the responsiveness of JB6 cells to TPA-induced transformation, we compared c-jun and c-fos expression as well as the AP-1-binding activity and the AP-1-mediated transactivation of the reporter construct TRE-CAT between bcl-2-expressing cells and control cells.	Tetradecanoylphorbol Acetate	142-145	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	46-65
9364213-6	1997	Because the level of the transcription factor activator protein 1 (AP-1) has been shown to be critical for the responsiveness of JB6 cells to TPA-induced transformation, we compared c-jun and c-fos expression as well as the AP-1-binding activity and the AP-1-mediated transactivation of the reporter construct TRE-CAT between bcl-2-expressing cells and control cells.	Tetradecanoylphorbol Acetate	142-145	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	67-71
9364213-8	1997	Furthermore, the levels of AP-1 and AP-1-induced transactivation of TRE-CAT were greater in bcl-2-transfected cells than in control cells after TPA treatment.	Tetradecanoylphorbol Acetate	144-147	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-31
9364213-8	1997	Furthermore, the levels of AP-1 and AP-1-induced transactivation of TRE-CAT were greater in bcl-2-transfected cells than in control cells after TPA treatment.	Tetradecanoylphorbol Acetate	144-147	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	36-40
9622599-6	1998	The effect of TGFbeta2 on Gel B secretion was reversed by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	58-83	transforming growth factor beta 2	Homo sapiens	14-22
9622599-6	1998	The effect of TGFbeta2 on Gel B secretion was reversed by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	58-83	matrix metallopeptidase 9	Homo sapiens	26-31
9622599-6	1998	The effect of TGFbeta2 on Gel B secretion was reversed by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	85-88	transforming growth factor beta 2	Homo sapiens	14-22
9622599-6	1998	The effect of TGFbeta2 on Gel B secretion was reversed by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	85-88	matrix metallopeptidase 9	Homo sapiens	26-31
9630570-6	1998	Further, the data also showed that the protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA 150 nM) reduced the spreading of the waves.	Tetradecanoylphorbol Acetate	105-108	protein kinase C, gamma	Rattus norvegicus	57-60
9612227-0	1998	Chronic exposure to TPA depletes PKC alpha and augments Ca-dependent insulin secretion from cultured rat islets.	Tetradecanoylphorbol Acetate	20-23	protein kinase C, alpha	Rattus norvegicus	33-42
9612227-4	1998	In agreement with previous studies, culturing in TPA reduced the islet content of immunoreactive PKC alpha by &gt; 95% and abolished the capacity of the phorbol ester to stimulate secretion during a subsequent dynamic perifusion.	Tetradecanoylphorbol Acetate	49-52	protein kinase C, alpha	Rattus norvegicus	97-106
3460639-2	1986	HL60 cells were shown to produce cathepsin B in response to treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	113-116	cathepsin B	Homo sapiens	33-44
9603453-6	1998	Restimulation with the protein kinase C activator phorbol 12-myristate 13-acetate and the calcium ionophore ionomycin or an agonistic anti-CD3 monoclonal antibody induced significant up-regulation of surface TRAIL and CD95L in CD3+, TCRalphabeta cells with CD4+ or CD8+ phenotype.	Tetradecanoylphorbol Acetate	50-81	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	208-213
3460639-3	1986	Intracellular levels of cathepsin B and immunohistochemical staining of the enzyme were related to time in culture with increasing concentrations of TPA from 1 nmol/1 to 8.0 nmol/1.	Tetradecanoylphorbol Acetate	149-152	cathepsin B	Homo sapiens	24-35
3460639-4	1986	Synthesis of cathepsin B was associated with TPA-induced phagocytic activity of cells in culture, expression of alpha-naphthyl acetate esterase and reduced cell division.	Tetradecanoylphorbol Acetate	45-48	cathepsin B	Homo sapiens	13-24
9374197-6	1997	Down-regulation of PKC by prolonged (18 h) treatment with 1 microM PMA prevented the A beta-induced S6 phosphorylation.	Tetradecanoylphorbol Acetate	67-70	protein kinase C, alpha	Rattus norvegicus	19-22
3460639-7	1986	The production of cathepsin B by TPA-induced HL60 cells was significantly reduced by 0.25 mumol/1 dexamethasone and the non-steroidal anti-inflammatory compound 4-(6-methoxy-2-naphthyl)-butan-2-one but not by indomethacin.	Tetradecanoylphorbol Acetate	33-36	cathepsin B	Homo sapiens	18-29
9374197-6	1997	Down-regulation of PKC by prolonged (18 h) treatment with 1 microM PMA prevented the A beta-induced S6 phosphorylation.	Tetradecanoylphorbol Acetate	67-70	amyloid beta precursor protein	Rattus norvegicus	85-91
9581809-4	1998	Syk was found to be associated with Fc alphaR and its phosphorylation was increased in phorbol myristate acetate (PMA)- and interferon-gamma (IFN-gamma)-treated U937 cells.	Tetradecanoylphorbol Acetate	87-112	spleen associated tyrosine kinase	Homo sapiens	0-3
3015445-1	1986	In order to investigate the correlation between stimulation of superoxide generation and induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) we have used the macrophage cell line J774.16 and a clone derived from this line that, by contrast with the parental line, is unable to generate superoxides in response to TPA.	Tetradecanoylphorbol Acetate	135-171	ornithine decarboxylase, structural 1	Mus musculus	127-130
9581809-4	1998	Syk was found to be associated with Fc alphaR and its phosphorylation was increased in phorbol myristate acetate (PMA)- and interferon-gamma (IFN-gamma)-treated U937 cells.	Tetradecanoylphorbol Acetate	114-117	spleen associated tyrosine kinase	Homo sapiens	0-3
9553058-8	1998	In T cells, overexpression of SPRK/MLK3, an activator of JNK/SAPK, strongly induces DSE-dependent transcription and dominant negative kinases of SEK and SAPK impair TPA/ionomycin-induced DSE activity.	Tetradecanoylphorbol Acetate	165-168	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	30-34
3015445-1	1986	In order to investigate the correlation between stimulation of superoxide generation and induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) we have used the macrophage cell line J774.16 and a clone derived from this line that, by contrast with the parental line, is unable to generate superoxides in response to TPA.	Tetradecanoylphorbol Acetate	173-176	ornithine decarboxylase, structural 1	Mus musculus	102-125
9553058-8	1998	In T cells, overexpression of SPRK/MLK3, an activator of JNK/SAPK, strongly induces DSE-dependent transcription and dominant negative kinases of SEK and SAPK impair TPA/ionomycin-induced DSE activity.	Tetradecanoylphorbol Acetate	165-168	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	35-39
9349751-6	1997	In addition, PMA inhibited hCG- and CRH-stimulated steroidogenesis in MA-10 cells and CRH-stimulated steroidogenesis in primary Leydig cells, suggesting that activation of the protein kinase C pathway can influence protein kinase A stimulated steroidogenesis.	Tetradecanoylphorbol Acetate	13-16	corticotropin releasing hormone	Mus musculus	36-39
3015445-1	1986	In order to investigate the correlation between stimulation of superoxide generation and induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) we have used the macrophage cell line J774.16 and a clone derived from this line that, by contrast with the parental line, is unable to generate superoxides in response to TPA.	Tetradecanoylphorbol Acetate	173-176	ornithine decarboxylase, structural 1	Mus musculus	127-130
9252399-3	1997	Responsiveness to 12-O-tetradecanoylphorbol-13-acetate (TPA) localized to the SP-B proximal promoter (-140/-65 bp) and specifically to binding sites for TTF-1 and HNF3, which act as cell-specific enhancers of SP-B expression.	Tetradecanoylphorbol Acetate	18-54	forkhead box M1	Homo sapiens	163-167
9252399-3	1997	Responsiveness to 12-O-tetradecanoylphorbol-13-acetate (TPA) localized to the SP-B proximal promoter (-140/-65 bp) and specifically to binding sites for TTF-1 and HNF3, which act as cell-specific enhancers of SP-B expression.	Tetradecanoylphorbol Acetate	56-59	forkhead box M1	Homo sapiens	163-167
3015445-1	1986	In order to investigate the correlation between stimulation of superoxide generation and induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) we have used the macrophage cell line J774.16 and a clone derived from this line that, by contrast with the parental line, is unable to generate superoxides in response to TPA.	Tetradecanoylphorbol Acetate	350-353	ornithine decarboxylase, structural 1	Mus musculus	127-130
9252399-4	1997	Treatment of cells with TPA (10 nM) caused a time-dependent decrease in both TTF-1 and HNF3 in nuclear extracts and accumulation of both factors in the cytoplasm as assessed by electromobility shift, Western, Southwestern, and immunofluorescence assays.	Tetradecanoylphorbol Acetate	24-27	forkhead box M1	Homo sapiens	87-91
9575847-10	1998	Taurocholate and phorbol 12-myristate 13-acetate suppressed mRNA (61 +/- 4% and 49 +/- 13%, respectively), suggesting that protein kinase C mediated effects of bile acids on CEH mRNA levels.	Tetradecanoylphorbol Acetate	17-48	epoxide hydrolase 2	Rattus norvegicus	174-177
3015445-2	1986	No difference was observed between the normal and the defective cells, with respect to ODC induction by TPA over a wide range of TPA concentrations (0.2-5.0 micrograms/ml).	Tetradecanoylphorbol Acetate	104-107	ornithine decarboxylase, structural 1	Mus musculus	87-90
9528979-6	1998	As determined by immunoblotting with anti-GHR cytoplasmic domain serum, addition of phorbol 12-myristate 13-acetate (PMA; 1 microg/ml) to serum-starved cells led to rapid loss (roughly 60% decline after 1 h; t(1/2) = approximately 5 min) of mature GHRs (115-140 kDa) from either total cell or detergent-soluble extracts.	Tetradecanoylphorbol Acetate	84-115	growth hormone receptor	Homo sapiens	42-45
9528979-6	1998	As determined by immunoblotting with anti-GHR cytoplasmic domain serum, addition of phorbol 12-myristate 13-acetate (PMA; 1 microg/ml) to serum-starved cells led to rapid loss (roughly 60% decline after 1 h; t(1/2) = approximately 5 min) of mature GHRs (115-140 kDa) from either total cell or detergent-soluble extracts.	Tetradecanoylphorbol Acetate	117-120	growth hormone receptor	Homo sapiens	42-45
3088111-10	1986	Although the small increase in (Ca++)i induced by 9.3 may account for its synergy with PMA, this effect is unlikely to account for the more potent synergistic effect observed with 9.3 and phytohemagglutinin or immobilized anti-T3 and anti-Ti antibodies.	Tetradecanoylphorbol Acetate	87-90	carbonic anhydrase 1	Homo sapiens	32-38
9535217-9	1998	PMA and okadaic acid induced an increase in HSF1 phosphorylation in both vector- and HSP-70 cDNA-transfected cells, although levels of phosphorylated HSF1 in HSP-70 cDNA-transfected cells were lower than those in vector-transfected cells.	Tetradecanoylphorbol Acetate	0-3	heat shock protein family A (Hsp70) member 4	Homo sapiens	85-91
9535217-9	1998	PMA and okadaic acid induced an increase in HSF1 phosphorylation in both vector- and HSP-70 cDNA-transfected cells, although levels of phosphorylated HSF1 in HSP-70 cDNA-transfected cells were lower than those in vector-transfected cells.	Tetradecanoylphorbol Acetate	0-3	heat shock protein family A (Hsp70) member 4	Homo sapiens	158-164
9277499-3	1997	Monocytic cell adhesion to EC in response to tumor necrosis factor-alpha (TNF-alpha), lipopolysaccharide (LPS), alpha-thrombin, or phorbol 12-myristate 13-acetate (PMA) was similarly inhibited by NAC.	Tetradecanoylphorbol Acetate	131-162	X-linked Kx blood group	Homo sapiens	196-199
3099748-0	1986	Increased mouse epidermal ornithine decarboxylase activity by the tumour promoter 12-O-tetradecanoylphorbol 13-acetate involves increased amounts of both enzyme protein and messenger RNA.	Tetradecanoylphorbol Acetate	82-118	ornithine decarboxylase, structural 1	Mus musculus	26-49
9242444-4	1997	Here, we report the cell surface association of MMP-9 in human breast epithelial MCF10A cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	107-143	matrix metallopeptidase 9	Homo sapiens	48-53
9242444-4	1997	Here, we report the cell surface association of MMP-9 in human breast epithelial MCF10A cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	145-148	matrix metallopeptidase 9	Homo sapiens	48-53
9242444-5	1997	Surface biotinylation and immunoprecipitation with anti-MMP-9 antibodies revealed the presence of two MMP-9 forms (M(r) 92,000 and 85,000) on the surface of TPA-treated MCF10A cells, whereas in the media, only the M(r) 92,000 form was detected, mostly in complex with TIMP-1, a specific MMP-9 inhibitor.	Tetradecanoylphorbol Acetate	157-160	matrix metallopeptidase 9	Homo sapiens	56-61
9517568-13	1998	ATP, TPA, or A23187 induced an increase in the activity and tyrosine phosphorylation of p42 MAPK, as well as a molecular weight shift, consistent with phosphorylation, of cytosolic phospholipase A2 (cPLA2).	Tetradecanoylphorbol Acetate	5-8	phospholipase A2 group IVA	Homo sapiens	171-197
9517568-13	1998	ATP, TPA, or A23187 induced an increase in the activity and tyrosine phosphorylation of p42 MAPK, as well as a molecular weight shift, consistent with phosphorylation, of cytosolic phospholipase A2 (cPLA2).	Tetradecanoylphorbol Acetate	5-8	phospholipase A2 group IVA	Homo sapiens	199-204
9242444-5	1997	Surface biotinylation and immunoprecipitation with anti-MMP-9 antibodies revealed the presence of two MMP-9 forms (M(r) 92,000 and 85,000) on the surface of TPA-treated MCF10A cells, whereas in the media, only the M(r) 92,000 form was detected, mostly in complex with TIMP-1, a specific MMP-9 inhibitor.	Tetradecanoylphorbol Acetate	157-160	matrix metallopeptidase 9	Homo sapiens	102-107
3099748-1	1986	Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein.	Tetradecanoylphorbol Acetate	45-81	ornithine decarboxylase, structural 1	Mus musculus	112-135
9242444-5	1997	Surface biotinylation and immunoprecipitation with anti-MMP-9 antibodies revealed the presence of two MMP-9 forms (M(r) 92,000 and 85,000) on the surface of TPA-treated MCF10A cells, whereas in the media, only the M(r) 92,000 form was detected, mostly in complex with TIMP-1, a specific MMP-9 inhibitor.	Tetradecanoylphorbol Acetate	157-160	matrix metallopeptidase 9	Homo sapiens	102-107
9242444-6	1997	The MMP-9 forms were also found in purified plasma membranes of TPA-treated cells.	Tetradecanoylphorbol Acetate	64-67	matrix metallopeptidase 9	Homo sapiens	4-9
3099748-1	1986	Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein.	Tetradecanoylphorbol Acetate	45-81	ornithine decarboxylase, structural 1	Mus musculus	137-140
9242444-10	1997	These studies demonstrate a specific cell surface association of MMP-9 in response to TPA that may help to localize TIMP-1-free enzyme on the surface of breast epithelial cells.	Tetradecanoylphorbol Acetate	86-89	matrix metallopeptidase 9	Homo sapiens	65-70
3099748-1	1986	Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein.	Tetradecanoylphorbol Acetate	45-81	ornithine decarboxylase, structural 1	Mus musculus	188-191
9540984-3	1998	This pattern of expression was retained over 7 d. The addition of 100 U interferon (IFN)-gamma per ml over 3 d and 1 nM phorbol myristate acetate over 24 h resulted in the expression of intercellular adhesion molecule (ICAM)-1 and HLA-DR by infundibular keratinocytes, as determined by immunohistochemistry.	Tetradecanoylphorbol Acetate	120-145	intercellular adhesion molecule 1	Homo sapiens	186-226
3099748-1	1986	Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein.	Tetradecanoylphorbol Acetate	45-81	ornithine decarboxylase, structural 1	Mus musculus	188-191
2424873-7	1986	Surface marker analysis revealed that the expression of CD2 to CD7 antigens (and also CD25) may be modified following incubation of the TLC with TPA or sodium butyrate but not with 5-azacytidine.	Tetradecanoylphorbol Acetate	145-148	CD7 molecule	Homo sapiens	63-66
9528769-2	1998	Here, we used in-gel kinase assays to determine that pp90rsk1 activated by either epidermal growth factor (EGF) or phorbol myristate acetate specifically phosphorylates Ser-167 within AF-1.	Tetradecanoylphorbol Acetate	115-140	interferon gamma receptor 2	Homo sapiens	184-188
9516439-11	1998	In contrast, the addition of recombinant Ral proteins (RalA and RalB), glucosylation substrates for TscL and TcdB-1470, but not for TcdB, to membranes of TcdB-1470- or TcsL-treated cells fully restored PLD stimulation by PMA without altering the strict MgATP dependence of PMA-induced PLD stimulation.	Tetradecanoylphorbol Acetate	221-224	RAS like proto-oncogene A	Homo sapiens	41-44
9516439-11	1998	In contrast, the addition of recombinant Ral proteins (RalA and RalB), glucosylation substrates for TscL and TcdB-1470, but not for TcdB, to membranes of TcdB-1470- or TcsL-treated cells fully restored PLD stimulation by PMA without altering the strict MgATP dependence of PMA-induced PLD stimulation.	Tetradecanoylphorbol Acetate	221-224	RAS like proto-oncogene A	Homo sapiens	55-59
9370104-3	1997	Sandalwood oil treatment significantly decreased papilloma incidence by 67%, multiplicity by 96%, and TPA-induced ODC activity by 70%.	Tetradecanoylphorbol Acetate	102-105	ornithine decarboxylase, structural 1	Mus musculus	114-117
9276765-11	1997	TPA-induced MPO increase was decreased by all COX-2 inhibitors.	Tetradecanoylphorbol Acetate	0-3	myeloperoxidase	Mus musculus	12-15
9276765-12	1997	Indomethacin and zileuton had similar effect on AA and TPA-induced increase in MPO.	Tetradecanoylphorbol Acetate	55-58	myeloperoxidase	Mus musculus	79-82
2423606-8	1986	This finding was in contrast to the continued O-2 production by phorbol myristate acetate-stimulated neutrophils similarly washed and resuspended in stimulus-free medium.	Tetradecanoylphorbol Acetate	64-89	immunoglobulin kappa variable 1D-39	Homo sapiens	46-49
9514905-3	1998	Furthermore, expression of the immediate early genes c-fos and c-jun was up-regulated by TPA only in LNCaP and DU-145 cells, whereas PC-3 cells failed to express c-fos mRNA.	Tetradecanoylphorbol Acetate	89-92	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	53-58
9514905-3	1998	Furthermore, expression of the immediate early genes c-fos and c-jun was up-regulated by TPA only in LNCaP and DU-145 cells, whereas PC-3 cells failed to express c-fos mRNA.	Tetradecanoylphorbol Acetate	89-92	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-68
9263987-2	1997	Short-term (30 min) pretreatment of endothelial cells with 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent activator of protein kinase C (PKC), decreases the ATP-stimulated phosphoinositide degradation and Ca2+ mobilization.	Tetradecanoylphorbol Acetate	59-95	protein kinase C alpha	Bos taurus	143-146
3711103-1	1986	The addition of the tumor promoting phorbol ester 12-O-tetradecanoyl phorbol 13-acetate to intact human red blood cells activates protein kinase C and stimulates the phosphorylation of the membrane skeletal proteins band 4.1 and band 4.9 as well as two proteins of molecular mass 115 and 110 kDa.	Tetradecanoylphorbol Acetate	50-87	erythrocyte membrane protein band 4.1	Homo sapiens	216-224
9263987-2	1997	Short-term (30 min) pretreatment of endothelial cells with 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent activator of protein kinase C (PKC), decreases the ATP-stimulated phosphoinositide degradation and Ca2+ mobilization.	Tetradecanoylphorbol Acetate	97-100	protein kinase C alpha	Bos taurus	143-146
9263987-8	1997	On exposure to TPA, a complete depletion of PKC-alpha is observed within four hours.	Tetradecanoylphorbol Acetate	15-18	protein kinase C alpha	Bos taurus	44-53
9263987-9	1997	In contrast, PKC-epsilon was more resistant to phorbol ester, and even after 48 hours of TPA treatment, only 60% of PKC-epsilon was down-regulated.	Tetradecanoylphorbol Acetate	89-92	protein kinase C epsilon	Bos taurus	13-24
9263987-9	1997	In contrast, PKC-epsilon was more resistant to phorbol ester, and even after 48 hours of TPA treatment, only 60% of PKC-epsilon was down-regulated.	Tetradecanoylphorbol Acetate	89-92	protein kinase C epsilon	Bos taurus	116-127
9525279-3	1998	At 24 h following topical application of TPA to the dorsal epidermis of mice, dermal leukocytes expressed higher levels of beta2 integrin protein compared with the lower levels of beta2 integrin protein expression by peripheral blood leukocytes.	Tetradecanoylphorbol Acetate	41-44	hemoglobin, beta adult minor chain	Mus musculus	123-128
9525279-3	1998	At 24 h following topical application of TPA to the dorsal epidermis of mice, dermal leukocytes expressed higher levels of beta2 integrin protein compared with the lower levels of beta2 integrin protein expression by peripheral blood leukocytes.	Tetradecanoylphorbol Acetate	41-44	hemoglobin, beta adult minor chain	Mus musculus	180-185
9525279-7	1998	In addition, injection of either anti-ICAM-1 adhesion molecule antibody alone (P &lt; 0.004) or in combination with anti-beta2 integrin antibody (P &lt; 0.001) significantly inhibited TPA-induced production of 7,8-dihydroxy-2"-deoxyguanosine (8-OHdG) immunoreactive proteins by epidermal keratinocytes.	Tetradecanoylphorbol Acetate	184-187	hemoglobin, beta adult minor chain	Mus musculus	121-126
9525279-8	1998	Beta2 integrin/ICAM-1 adhesion molecules work in concert to regulate migration, retention and functional activation of leukocytes within the dermis during TPA-induced skin inflammation and within stromal tissue of papillomas that form during multi-stage carcinogenesis.	Tetradecanoylphorbol Acetate	155-158	hemoglobin, beta adult minor chain	Mus musculus	0-5
3087287-0	1986	Induction of mouse epidermal ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate: dependence on calcium availability.	Tetradecanoylphorbol Acetate	75-111	ornithine decarboxylase, structural 1	Mus musculus	29-52
9543636-5	1998	RESULTS: A phorbol mitogen (TPA), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B, stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression; TIMP-2 levels are reduced by TNF but not affected by the other treatments.	Tetradecanoylphorbol Acetate	28-31	TIMP metallopeptidase inhibitor 2	Homo sapiens	235-241
9245716-1	1997	Following induction of cell differentiation in vitro, an increase in Syk activity was observed only in HL60 cells differentiation into granulocytes induced by all trans retinoic acid (RA) but not into macrophages induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) or monocytes induced by sodium butyrate.	Tetradecanoylphorbol Acetate	224-260	spleen associated tyrosine kinase	Homo sapiens	69-72
9245716-1	1997	Following induction of cell differentiation in vitro, an increase in Syk activity was observed only in HL60 cells differentiation into granulocytes induced by all trans retinoic acid (RA) but not into macrophages induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) or monocytes induced by sodium butyrate.	Tetradecanoylphorbol Acetate	262-265	spleen associated tyrosine kinase	Homo sapiens	69-72
3087287-1	1986	The role of calcium in epidermal ornithine decarboxylase (ODC) induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) was determined in adult mouse skin pieces incubated in serum-free minimal essential medium (MEM).	Tetradecanoylphorbol Acetate	76-112	ornithine decarboxylase, structural 1	Mus musculus	33-56
9515031-3	1998	In the transient transfection assay, TGF-beta1 potentiated NE- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-activated c-fos promoter/enhancer, but not forskolin-activated c-fos promoter/enhancer.	Tetradecanoylphorbol Acetate	66-102	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	119-124
9515031-3	1998	In the transient transfection assay, TGF-beta1 potentiated NE- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-activated c-fos promoter/enhancer, but not forskolin-activated c-fos promoter/enhancer.	Tetradecanoylphorbol Acetate	104-107	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	119-124
3087287-1	1986	The role of calcium in epidermal ornithine decarboxylase (ODC) induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) was determined in adult mouse skin pieces incubated in serum-free minimal essential medium (MEM).	Tetradecanoylphorbol Acetate	76-112	ornithine decarboxylase, structural 1	Mus musculus	58-61
9515031-3	1998	In the transient transfection assay, TGF-beta1 potentiated NE- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-activated c-fos promoter/enhancer, but not forskolin-activated c-fos promoter/enhancer.	Tetradecanoylphorbol Acetate	104-107	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	172-177
9515031-4	1998	The c-fos serum response element (SRE) and the TPA response element (TRE) were responsible for TGF-beta1-induced potentiation of the NE or TPA action.	Tetradecanoylphorbol Acetate	139-142	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	4-9
9515031-5	1998	Although TGF-beta1 activated not only the wild-type c-fos SRE, but also the mutated c-fos SRE, which contains an intact binding site for the serum response factor (SRF) but lacks the ternary complex factor (TCF) binding site, TPA activated the wild-type c-fos SRE but not the mutated c-fos SRE.	Tetradecanoylphorbol Acetate	226-229	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-89
9515031-5	1998	Although TGF-beta1 activated not only the wild-type c-fos SRE, but also the mutated c-fos SRE, which contains an intact binding site for the serum response factor (SRF) but lacks the ternary complex factor (TCF) binding site, TPA activated the wild-type c-fos SRE but not the mutated c-fos SRE.	Tetradecanoylphorbol Acetate	226-229	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-89
9515031-5	1998	Although TGF-beta1 activated not only the wild-type c-fos SRE, but also the mutated c-fos SRE, which contains an intact binding site for the serum response factor (SRF) but lacks the ternary complex factor (TCF) binding site, TPA activated the wild-type c-fos SRE but not the mutated c-fos SRE.	Tetradecanoylphorbol Acetate	226-229	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-89
9272645-3	1997	Glutamate production by such cells was enhanced, in a concentration-dependent manner, by treatment with serum-opsonized zymosan (OZ), lipopolysaccharide (LPS), phorbol myristate acetate (PMA), and beta-amyloid peptide Abeta (1-40); but not by treatment with the reverse Abeta (40-1) or the Abeta (25-35) subfragment.	Tetradecanoylphorbol Acetate	187-190	amyloid beta precursor protein	Rattus norvegicus	218-223
9272645-3	1997	Glutamate production by such cells was enhanced, in a concentration-dependent manner, by treatment with serum-opsonized zymosan (OZ), lipopolysaccharide (LPS), phorbol myristate acetate (PMA), and beta-amyloid peptide Abeta (1-40); but not by treatment with the reverse Abeta (40-1) or the Abeta (25-35) subfragment.	Tetradecanoylphorbol Acetate	187-190	amyloid beta precursor protein	Rattus norvegicus	270-275
9272645-3	1997	Glutamate production by such cells was enhanced, in a concentration-dependent manner, by treatment with serum-opsonized zymosan (OZ), lipopolysaccharide (LPS), phorbol myristate acetate (PMA), and beta-amyloid peptide Abeta (1-40); but not by treatment with the reverse Abeta (40-1) or the Abeta (25-35) subfragment.	Tetradecanoylphorbol Acetate	187-190	amyloid beta precursor protein	Rattus norvegicus	270-275
3087287-1	1986	The role of calcium in epidermal ornithine decarboxylase (ODC) induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) was determined in adult mouse skin pieces incubated in serum-free minimal essential medium (MEM).	Tetradecanoylphorbol Acetate	114-117	ornithine decarboxylase, structural 1	Mus musculus	33-56
3087287-1	1986	The role of calcium in epidermal ornithine decarboxylase (ODC) induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) was determined in adult mouse skin pieces incubated in serum-free minimal essential medium (MEM).	Tetradecanoylphorbol Acetate	114-117	ornithine decarboxylase, structural 1	Mus musculus	58-61
9202001-7	1997	This differential substrate specificity of MKP-1 can be functionally extended to nuclear transcriptional events in that PMA-induced c-Jun transcriptional activity was more sensitive to inhibition by MKP-1 than either Elk-1 or c-Myc.	Tetradecanoylphorbol Acetate	120-123	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-137
9499065-8	1998	Flow cytometric analysis revealed that this effect may be due largely to up-regulation of CXCR4 expression by SDF-1alpha on CrFK cells, an effect mimicked by treatment of the cells with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	186-211	C-X-C motif chemokine receptor 4	Felis catus	90-95
9202001-7	1997	This differential substrate specificity of MKP-1 can be functionally extended to nuclear transcriptional events in that PMA-induced c-Jun transcriptional activity was more sensitive to inhibition by MKP-1 than either Elk-1 or c-Myc.	Tetradecanoylphorbol Acetate	120-123	ETS transcription factor ELK1	Homo sapiens	217-222
3087287-2	1986	Addition of TPA to skin pieces incubated in serum-free MEM, which contains 1.82 mM Ca2+ and 0.83 mM Mg2+, resulted in about a 200-fold increase in epidermal ODC activity at about 8 h after TPA treatment.	Tetradecanoylphorbol Acetate	12-15	ornithine decarboxylase, structural 1	Mus musculus	157-160
3087287-4	1986	Similarly, chelation of extracellular calcium by ethyleneglycol bis(beta-aminoethyl ether) N,N"-tetraacetic acid (EGTA) prevented ODC induction by TPA, which could be resumed upon calcium restoration in the medium.	Tetradecanoylphorbol Acetate	147-150	ornithine decarboxylase, structural 1	Mus musculus	130-133
9545106-12	1998	In nearly all cell types, treatment with PMA, IL-1, and TNF-alpha caused an increase of the MMP-9 mRNA levels.	Tetradecanoylphorbol Acetate	41-44	matrix metallopeptidase 9	Homo sapiens	92-97
3087287-6	1986	Epidermal ODC activity increased by TPA appears to be the result of an increase in both the amount of ODC protein and the level of hybridizable ODC messenger.	Tetradecanoylphorbol Acetate	36-39	ornithine decarboxylase, structural 1	Mus musculus	10-13
9478937-5	1998	Functional activation of the JNKK/SEK1-JNK/SAPK-c-Jun cascade (where JNKK/SEK1 is JNK kinase/SAPK kinase) was demonstrated by activation of a 12-O-tetradecanoylphorbol-13-acetate response element (TRE) reporter construct in a c-Jun dependent fashion.	Tetradecanoylphorbol Acetate	142-178	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	48-53
9218873-8	1997	This TRE bound TPA induced specific nuclear complexes in vitro containing junD, c-jun, c-fos, and fra2 but not cAMP-responsive element binding/activating transcription factor family proteins.	Tetradecanoylphorbol Acetate	15-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	87-92
9218873-8	1997	This TRE bound TPA induced specific nuclear complexes in vitro containing junD, c-jun, c-fos, and fra2 but not cAMP-responsive element binding/activating transcription factor family proteins.	Tetradecanoylphorbol Acetate	15-18	FOS like 2, AP-1 transcription factor subunit	Homo sapiens	98-102
2423265-0	1986	Heterogeneity of ornithine decarboxylase expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin and in epidermal tumors.	Tetradecanoylphorbol Acetate	55-91	ornithine decarboxylase, structural 1	Mus musculus	17-40
9218873-13	1997	These data show that the ICAM-TRE and its cognate jun- and fos-containing transcription factors play a predominant role in the transcriptional response of ICAM-1 to the protein kinase C activator TPA in SK-N-SH cells.	Tetradecanoylphorbol Acetate	196-199	intercellular adhesion molecule 1	Homo sapiens	155-161
9219725-7	1997	Phorbol ester (PMA), which induces protein-kinase C mediated signal transduction and enhances cellular differentiation in many non-small cell lung cancer (NSCLC) cell lines, increased intracellular Cat B activity and Cat B protein as well as its secretion in some cell lines but not in others, regardless of their histological type.	Tetradecanoylphorbol Acetate	15-18	cathepsin B	Homo sapiens	198-203
9511724-8	1998	Long-term treatment with either the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) or bryostatin 1 inhibited levels of Dsg1 and Dsg3, but not Dsg2 in NHEKs and HaCaT cells.	Tetradecanoylphorbol Acetate	50-86	desmoglein 1	Homo sapiens	129-133
9511724-8	1998	Long-term treatment with either the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) or bryostatin 1 inhibited levels of Dsg1 and Dsg3, but not Dsg2 in NHEKs and HaCaT cells.	Tetradecanoylphorbol Acetate	88-91	desmoglein 1	Homo sapiens	129-133
9511724-9	1998	Chronic TPA also decreased Dsg1 and Dsg3 mRNA levels in NHEKs, further supporting a role for PKC activation in the expression of the suprabasal Dsg1 and Dsg3.	Tetradecanoylphorbol Acetate	8-11	desmoglein 1	Homo sapiens	27-31
9511724-9	1998	Chronic TPA also decreased Dsg1 and Dsg3 mRNA levels in NHEKs, further supporting a role for PKC activation in the expression of the suprabasal Dsg1 and Dsg3.	Tetradecanoylphorbol Acetate	8-11	desmoglein 1	Homo sapiens	144-148
9484776-8	1998	Keratinocytes from the HK1.bcl-2 mice were significantly more resistant to cell death induction by U.V.-B, DMBA, and TPA, compared to control keratinocytes.	Tetradecanoylphorbol Acetate	117-120	hexokinase 1	Mus musculus	23-26
9484776-9	1998	Furthermore, papillomas developed at a significantly greater frequency and shorter latency in the HK1.bcl-2 mice compared to control littermates following initiation with DMBA and promotion with TPA.	Tetradecanoylphorbol Acetate	195-198	hexokinase 1	Mus musculus	98-101
9219725-7	1997	Phorbol ester (PMA), which induces protein-kinase C mediated signal transduction and enhances cellular differentiation in many non-small cell lung cancer (NSCLC) cell lines, increased intracellular Cat B activity and Cat B protein as well as its secretion in some cell lines but not in others, regardless of their histological type.	Tetradecanoylphorbol Acetate	15-18	cathepsin B	Homo sapiens	217-222
2423265-1	1986	One of the earliest events after treatment of mouse skin with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is the induction of ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	81-117	ornithine decarboxylase, structural 1	Mus musculus	144-167
2423265-1	1986	One of the earliest events after treatment of mouse skin with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is the induction of ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	81-117	ornithine decarboxylase, structural 1	Mus musculus	169-172
9426300-3	1998	The present study shows that down-regulation of PKC by prolonged (2 h) treatment with 0.1 muM 12-O-tetradecanoylphorbol-13-acetate (TPA) markedly reduced basal CCK receptor phosphorylation as well as that induced by TPA (0.1 muM) and cholecystokinin-(26-33)-peptide amide (CCK8, 0.1 muM).	Tetradecanoylphorbol Acetate	94-130	protein kinase C, gamma	Rattus norvegicus	48-51
2423265-1	1986	One of the earliest events after treatment of mouse skin with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is the induction of ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	119-122	ornithine decarboxylase, structural 1	Mus musculus	144-167
9426300-3	1998	The present study shows that down-regulation of PKC by prolonged (2 h) treatment with 0.1 muM 12-O-tetradecanoylphorbol-13-acetate (TPA) markedly reduced basal CCK receptor phosphorylation as well as that induced by TPA (0.1 muM) and cholecystokinin-(26-33)-peptide amide (CCK8, 0.1 muM).	Tetradecanoylphorbol Acetate	94-130	cholecystokinin	Rattus norvegicus	160-163
9426300-3	1998	The present study shows that down-regulation of PKC by prolonged (2 h) treatment with 0.1 muM 12-O-tetradecanoylphorbol-13-acetate (TPA) markedly reduced basal CCK receptor phosphorylation as well as that induced by TPA (0.1 muM) and cholecystokinin-(26-33)-peptide amide (CCK8, 0.1 muM).	Tetradecanoylphorbol Acetate	132-135	protein kinase C, gamma	Rattus norvegicus	48-51
9279477-3	1997	Pretreatment with 1 microM TPA and 10 nM insulin for 60 min resulted in the marked decreases of insulin-induced [3H]2-DOG uptake.	Tetradecanoylphorbol Acetate	27-30	insulin	Canis lupus familiaris	96-103
9426300-3	1998	The present study shows that down-regulation of PKC by prolonged (2 h) treatment with 0.1 muM 12-O-tetradecanoylphorbol-13-acetate (TPA) markedly reduced basal CCK receptor phosphorylation as well as that induced by TPA (0.1 muM) and cholecystokinin-(26-33)-peptide amide (CCK8, 0.1 muM).	Tetradecanoylphorbol Acetate	132-135	cholecystokinin	Rattus norvegicus	160-163
9279477-4	1997	Translocation of Mono Q column-purified cytosolic PKC enzyme activity and PKC beta immunoreactivity from cytosol to the membrane was suppressed by pretreatment with TPA and insulin for 60 min.	Tetradecanoylphorbol Acetate	165-168	protein kinase C, beta	Rattus norvegicus	50-53
2423265-1	1986	One of the earliest events after treatment of mouse skin with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is the induction of ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	119-122	ornithine decarboxylase, structural 1	Mus musculus	169-172
9279477-4	1997	Translocation of Mono Q column-purified cytosolic PKC enzyme activity and PKC beta immunoreactivity from cytosol to the membrane was suppressed by pretreatment with TPA and insulin for 60 min.	Tetradecanoylphorbol Acetate	165-168	protein kinase C, beta	Rattus norvegicus	74-82
9426300-3	1998	The present study shows that down-regulation of PKC by prolonged (2 h) treatment with 0.1 muM 12-O-tetradecanoylphorbol-13-acetate (TPA) markedly reduced basal CCK receptor phosphorylation as well as that induced by TPA (0.1 muM) and cholecystokinin-(26-33)-peptide amide (CCK8, 0.1 muM).	Tetradecanoylphorbol Acetate	216-219	protein kinase C, gamma	Rattus norvegicus	48-51
2423265-2	1986	Using an immunoperoxidase technique with a rabbit antiserum specific for ODC, the localization of cells containing high levels of ODC following TPA treatment was determined.	Tetradecanoylphorbol Acetate	144-147	ornithine decarboxylase, structural 1	Mus musculus	73-76
9279477-5	1997	These results indicate that acute treatment with TPA and insulin which are PKC activators suppress translocation/activation of PKC, and accordingly inhibit insulin-induced glucose uptake.	Tetradecanoylphorbol Acetate	49-52	protein kinase C, beta	Rattus norvegicus	75-78
9279477-5	1997	These results indicate that acute treatment with TPA and insulin which are PKC activators suppress translocation/activation of PKC, and accordingly inhibit insulin-induced glucose uptake.	Tetradecanoylphorbol Acetate	49-52	protein kinase C, beta	Rattus norvegicus	127-130
2423265-2	1986	Using an immunoperoxidase technique with a rabbit antiserum specific for ODC, the localization of cells containing high levels of ODC following TPA treatment was determined.	Tetradecanoylphorbol Acetate	144-147	ornithine decarboxylase, structural 1	Mus musculus	130-133
9279477-5	1997	These results indicate that acute treatment with TPA and insulin which are PKC activators suppress translocation/activation of PKC, and accordingly inhibit insulin-induced glucose uptake.	Tetradecanoylphorbol Acetate	49-52	insulin	Canis lupus familiaris	156-163
2423265-3	1986	CD-1 female mice treated with multiple topical applications of TPA and killed 4.5 h after the last TPA treatment exhibited a heterogeneous localization of ODC in this hyperplastic epidermis.	Tetradecanoylphorbol Acetate	63-66	ornithine decarboxylase, structural 1	Mus musculus	155-158
9279477-6	1997	We suggest that a decrease of cytosolic PKC activity may mainly-contribute to the impaired responsiveness of the glucose transport system after acute TPA and insulin treatment.	Tetradecanoylphorbol Acetate	150-153	protein kinase C, beta	Rattus norvegicus	40-43
9426300-7	1998	In addition, TPA-induced inhibition of the increase in cytosolic free Ca2+ concentration ([Ca2+]i) evoked by the high-affinity CCK receptor agonist JMV-180 was completely reversed.	Tetradecanoylphorbol Acetate	13-16	cholecystokinin	Rattus norvegicus	127-130
2423265-5	1986	This specific ODC staining in cells surrounding hair follicles was inhibited by pretreatment of mice with either retinoic acid or cycloheximide 1 h before TPA treatment.	Tetradecanoylphorbol Acetate	155-158	ornithine decarboxylase, structural 1	Mus musculus	14-17
2423265-6	1986	The induction of ODC-specific staining after TPA treatment in hyperplastic mouse skin was transient, since no staining was observed 16 or 24 h after TPA treatment.	Tetradecanoylphorbol Acetate	45-48	ornithine decarboxylase, structural 1	Mus musculus	17-20
9442079-3	1998	The TPA-induced p130cas phosphorylation increased within 5 min of stimulation and persisted for at least 4 days, whereas bFGF/IGF-I-induced p130cas phosphorylation was biphasic.	Tetradecanoylphorbol Acetate	4-7	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	16-20
9211989-3	1997	Immunoprecipitation and immunoblotting of the culture medium with monoclonal antibodies demonstrated a rapid onset of synthesis and secretion of Mr 280,000 tenascin (Tn) polypeptide with TPA and both Mr 280,000 and 190,000 Tn polypeptides with RA and an increased secretion of extradomain A cellular fibronectin (EDA-Fn) upon both treatments.	Tetradecanoylphorbol Acetate	187-190	tenascin C	Homo sapiens	156-164
9211989-3	1997	Immunoprecipitation and immunoblotting of the culture medium with monoclonal antibodies demonstrated a rapid onset of synthesis and secretion of Mr 280,000 tenascin (Tn) polypeptide with TPA and both Mr 280,000 and 190,000 Tn polypeptides with RA and an increased secretion of extradomain A cellular fibronectin (EDA-Fn) upon both treatments.	Tetradecanoylphorbol Acetate	187-190	tenascin C	Homo sapiens	166-168
9301678-5	1997	Expression of the c-myc gene was down-regulated and c-jun and c-fms transcripts increased following exposure to 5-500 nM TPA.	Tetradecanoylphorbol Acetate	121-124	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-57
9828078-2	1998	It has been shown previously that IFN-gamma induces increased CB activity in phorbol myristate acetate (PMA)-primed THP-1 cells.	Tetradecanoylphorbol Acetate	77-102	cathepsin B	Homo sapiens	62-64
2423265-6	1986	The induction of ODC-specific staining after TPA treatment in hyperplastic mouse skin was transient, since no staining was observed 16 or 24 h after TPA treatment.	Tetradecanoylphorbol Acetate	149-152	ornithine decarboxylase, structural 1	Mus musculus	17-20
9828078-2	1998	It has been shown previously that IFN-gamma induces increased CB activity in phorbol myristate acetate (PMA)-primed THP-1 cells.	Tetradecanoylphorbol Acetate	104-107	cathepsin B	Homo sapiens	62-64
2423265-7	1986	In contrast, benign papillomas produced by two-stage tumorigenesis contained some cells demonstrating high levels of ODC a week after the last TPA application.	Tetradecanoylphorbol Acetate	143-146	ornithine decarboxylase, structural 1	Mus musculus	117-120
2871947-12	1986	TPA treatment also increased ornithine decarboxylase activity in all lines, even at the higher Ca2+ concentration, although normal keratinocytes respond only when grown in medium with low Ca2+.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	29-52
9472663-1	1998	We have measured by flow cytometry the ability of subsets of CD8+CD3+ lymphocytes within mononuclear cell preparations to make intracellular cytokines (IL-2, tumour necrosis factor-alpha (TNF-alpha) and IFN-gamma) on stimulation in vitro with phorbol myristate acetate (PMA) and ionomycin for 16 h. These CD8+ subsets were defined by the presence or absence of CD28 or HLA-DR. Subsets of normal CD8+ cells were compared with cells from the antibody deficiency disease common variable immunodeficiency (CVID).	Tetradecanoylphorbol Acetate	243-268	CD8a molecule	Homo sapiens	61-64
9472663-1	1998	We have measured by flow cytometry the ability of subsets of CD8+CD3+ lymphocytes within mononuclear cell preparations to make intracellular cytokines (IL-2, tumour necrosis factor-alpha (TNF-alpha) and IFN-gamma) on stimulation in vitro with phorbol myristate acetate (PMA) and ionomycin for 16 h. These CD8+ subsets were defined by the presence or absence of CD28 or HLA-DR. Subsets of normal CD8+ cells were compared with cells from the antibody deficiency disease common variable immunodeficiency (CVID).	Tetradecanoylphorbol Acetate	270-273	CD8a molecule	Homo sapiens	61-64
9791941-5	1998	Using this approach it can be concluded that activation of the cells with phorbol-12-myristate-13-acetate causes a change in the redox state of cytochrome b558.	Tetradecanoylphorbol Acetate	74-105	mitochondrially encoded cytochrome b	Homo sapiens	144-156
9301678-6	1997	In contrast, exposure to 0.5 nM TPA decreased c-myc expression and increased c-jun transcripts only transiently between 4 and 8 h while little if any effect was detectable on c-fms mRNA expression and subsequent differentiation.	Tetradecanoylphorbol Acetate	32-35	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-82
9182576-6	1997	Thrombin and the phorbol ester, phorbol 12-myristate 13-acetate, also increased p125(FAK) tyrosine phosphorylation in HUVECs.	Tetradecanoylphorbol Acetate	32-63	SEC23 interacting protein	Homo sapiens	80-84
3466024-1	1986	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced megakaryoblastic differentiation and c-sis expression in the human hematopoietic stem cell line K-562.	Tetradecanoylphorbol Acetate	18-54	platelet derived growth factor subunit B	Homo sapiens	106-111
9179381-11	1997	Both the neutrophil cytosolic protein kinase C (PKC) activity and the PMA-induced PKC associated with the membrane were unaffected by acetylshikonin.	Tetradecanoylphorbol Acetate	70-73	protein kinase C, gamma	Rattus norvegicus	82-85
9208127-17	1997	As well as affecting p53, TPA elicited a rapid decline of the steady state level of Bax within 30 min.	Tetradecanoylphorbol Acetate	26-29	BCL2-associated X protein	Mus musculus	84-87
9710361-8	1998	This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min.	Tetradecanoylphorbol Acetate	97-100	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	299-303
9710361-8	1998	This response was transient, as the level returned to the control level after 6 h. Forskolin and TPA evoked similar increases, but their effects appeared after 30 min and reached their maxima after 2 h. In contrast, GRF and forskolin, but not TPA, increased the GH mRNA level 2-fold after 24 h. The cJun mRNA level showed no significant change in response to these agents over 24 h and GRF and TPA increased the cFos mRNA level 1.4 and 2.3-fold, respectively, after 30 min.	Tetradecanoylphorbol Acetate	97-100	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	412-416
9710361-10	1998	Furthermore, the GRF-induced increase in cFos mRNA level by GRF and TPA did not appear to be participated straightforward in the GH gene expression, suggesting that cFos alone is insufficient to the activation.	Tetradecanoylphorbol Acetate	68-71	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	41-45
3466024-1	1986	The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced megakaryoblastic differentiation and c-sis expression in the human hematopoietic stem cell line K-562.	Tetradecanoylphorbol Acetate	56-59	platelet derived growth factor subunit B	Homo sapiens	106-111
9472737-7	1998	Activation of PKC by phorbol 12-myristate 13-acetate (20 nM) decreased I(IsK) (gerbil: by 62 +/- 10%; rat: by 72 +/- 6%) in perforated-patch whole-cell recordings while the inactive analog, 4alphaPMA, had no effect.	Tetradecanoylphorbol Acetate	21-52	protein kinase C, gamma	Rattus norvegicus	14-17
9168824-5	1997	Activation of PKC by exposure of resident PM phi to phorbol myristate acetate (PMA) also resulted in enhanced IL-6 release and PMA was shown to synergize with CSF-1.	Tetradecanoylphorbol Acetate	79-82	colony stimulating factor 1 (macrophage)	Mus musculus	159-164
3082993-1	1986	The murine T lymphoma EL4 subline produces large amounts of interleukin 2 (IL-2) upon stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	103-128	epilepsy 4	Mus musculus	22-25
3082993-1	1986	The murine T lymphoma EL4 subline produces large amounts of interleukin 2 (IL-2) upon stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	130-133	epilepsy 4	Mus musculus	22-25
9135074-6	1997	Adult HK1.IGF-1 mice developed spontaneous tumors following treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) alone and exhibited an exaggerated epidermal proliferative response following treatment with the tumor promoter compared to non transgenic littermates.	Tetradecanoylphorbol Acetate	75-111	hexokinase 1	Mus musculus	6-9
3082993-6	1986	The reverted EL4 cells were again able to produce large amounts of IL-2 upon restimulation with PMA.	Tetradecanoylphorbol Acetate	96-99	epilepsy 4	Mus musculus	13-16
9135074-6	1997	Adult HK1.IGF-1 mice developed spontaneous tumors following treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) alone and exhibited an exaggerated epidermal proliferative response following treatment with the tumor promoter compared to non transgenic littermates.	Tetradecanoylphorbol Acetate	113-116	hexokinase 1	Mus musculus	6-9
3081251-1	1986	Palmitoylcarnitine, which has been reported to be an inhibitor of calcium-activated, phospholipid-dependent protein kinase (protein kinase C), inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced epidermal ornithine decarboxylase in mouse skin in a dose-dependent manner.	Tetradecanoylphorbol Acetate	191-194	ornithine decarboxylase, structural 1	Mus musculus	214-237
9106500-11	1997	When the thymocytes were activated with 12-O-tetradecanoylpholbol-13-acetate (TPA) and calcium ionophore A23187, the proportion of AC1+ cells increased remarkably and were detected not only in CD4+ cells but also in CD8+ cells.	Tetradecanoylphorbol Acetate	78-81	Cd4 molecule	Rattus norvegicus	193-196
9173892-5	1997	Stimulation of AtT-20 cells with either forskolin or phorbol 12-myristate 13-acetate induces the secretion of wild-type CPE and of CPE lacking the pro region to similar extents, indicating a similar efficiency of sorting of the mutant.	Tetradecanoylphorbol Acetate	53-84	carboxypeptidase E	Mus musculus	120-123
9173892-5	1997	Stimulation of AtT-20 cells with either forskolin or phorbol 12-myristate 13-acetate induces the secretion of wild-type CPE and of CPE lacking the pro region to similar extents, indicating a similar efficiency of sorting of the mutant.	Tetradecanoylphorbol Acetate	53-84	carboxypeptidase E	Mus musculus	131-134
9150350-2	1997	In the present study, we prepared a karyotype of MONO-MAC-1, analysed the growth behaviour, determined the presence of differentiation-associated antigens and studied the expression and secretion of several cytokines upon stimulation with 12-O-tetradecanoyl phorbol 13-acetate (TPA) and lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	239-276	integrin subunit alpha M	Homo sapiens	54-59
9596928-6	1997	U937 cells stimulated by low dosage PMA adhered with coated C 33, and the adhesion was blocked by anti-CD 11b monoclonal antibody.	Tetradecanoylphorbol Acetate	36-39	integrin subunit alpha M	Homo sapiens	103-109
9075429-5	1997	However, during stimulation with beta-phorbol 12-myristate 13-acetate, the increase in CD11b expression in neutrophils from patients with diabetes was significantly less than in controls.	Tetradecanoylphorbol Acetate	33-69	integrin subunit alpha M	Homo sapiens	87-92
9067545-6	1997	Overexpression of MnSOD led to a significant decrease in c-jun and c-fos expression in response to treatment with TPA or the oxidant promoter superoxide.	Tetradecanoylphorbol Acetate	114-117	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-62
9067545-6	1997	Overexpression of MnSOD led to a significant decrease in c-jun and c-fos expression in response to treatment with TPA or the oxidant promoter superoxide.	Tetradecanoylphorbol Acetate	114-117	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	67-72
9115810-3	1997	Pretreatment of ACH-2 T cells by NAC followed by stimulation with PMA, TNF-alpha, or hydrogen peroxide (H2O2) resulted in strong suppression of NF-kappa B activation.	Tetradecanoylphorbol Acetate	66-69	acyl-CoA thioesterase 1	Homo sapiens	16-21
9042336-6	1997	The effect of PAF on c-fos gene expression was not prevented by pre incubation with the PTK inhibitors genistein or methyl-2,5-dihydroxycinnamate, whereas was strongly affected by PKC down regulation after long term incubation with PMA or by PKC inhibition with sangivamycin.	Tetradecanoylphorbol Acetate	232-235	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-26
9068340-4	1997	Halothane and PMA in combination reduced membrane PKC activity to undetectable levels and reduced cytosol PKC activity (P &lt; 0.01).	Tetradecanoylphorbol Acetate	14-17	protein kinase C, alpha	Rattus norvegicus	50-53
9068340-4	1997	Halothane and PMA in combination reduced membrane PKC activity to undetectable levels and reduced cytosol PKC activity (P &lt; 0.01).	Tetradecanoylphorbol Acetate	14-17	protein kinase C, alpha	Rattus norvegicus	106-109
9068340-7	1997	Experiments using isoform-selective antibodies to PKC alpha, PKC beta or PKC gamma demonstrated synergistic interactions between halothane and PMA in promoting translocation of the three conventional PKC isoforms from the cytosol to the membrane fraction of synaptosomes and down-regulation of their immunoreactivity.	Tetradecanoylphorbol Acetate	143-146	protein kinase C, alpha	Rattus norvegicus	50-59
9068340-7	1997	Experiments using isoform-selective antibodies to PKC alpha, PKC beta or PKC gamma demonstrated synergistic interactions between halothane and PMA in promoting translocation of the three conventional PKC isoforms from the cytosol to the membrane fraction of synaptosomes and down-regulation of their immunoreactivity.	Tetradecanoylphorbol Acetate	143-146	protein kinase C, beta	Rattus norvegicus	61-69
9068340-7	1997	Experiments using isoform-selective antibodies to PKC alpha, PKC beta or PKC gamma demonstrated synergistic interactions between halothane and PMA in promoting translocation of the three conventional PKC isoforms from the cytosol to the membrane fraction of synaptosomes and down-regulation of their immunoreactivity.	Tetradecanoylphorbol Acetate	143-146	protein kinase C, gamma	Rattus norvegicus	73-82
9068340-7	1997	Experiments using isoform-selective antibodies to PKC alpha, PKC beta or PKC gamma demonstrated synergistic interactions between halothane and PMA in promoting translocation of the three conventional PKC isoforms from the cytosol to the membrane fraction of synaptosomes and down-regulation of their immunoreactivity.	Tetradecanoylphorbol Acetate	143-146	protein kinase C, alpha	Rattus norvegicus	50-53
9068340-8	1997	Halothane and PMA together reduced cytosol PKC alpha/beta/gamma immunoreactivity significantly more (P &lt; 0.05) than PMA alone.	Tetradecanoylphorbol Acetate	14-17	protein kinase C, alpha	Rattus norvegicus	43-52
9040941-6	1997	Because WASP also binds to Ash/Grb2 SH3 domains and the association of Ash/Grb2 and Shc is induced by 12-O-tetradecanoylphorbol 13-acetate treatment, a signaling pathway, PKC-tyrosine kinase-Shc-Ash/Grb2-WASP, is suggested for regulating megakaryocyte differentiation.	Tetradecanoylphorbol Acetate	102-138	SHC adaptor protein 1	Homo sapiens	84-87
9040941-6	1997	Because WASP also binds to Ash/Grb2 SH3 domains and the association of Ash/Grb2 and Shc is induced by 12-O-tetradecanoylphorbol 13-acetate treatment, a signaling pathway, PKC-tyrosine kinase-Shc-Ash/Grb2-WASP, is suggested for regulating megakaryocyte differentiation.	Tetradecanoylphorbol Acetate	102-138	TXK tyrosine kinase	Homo sapiens	175-190
9040941-6	1997	Because WASP also binds to Ash/Grb2 SH3 domains and the association of Ash/Grb2 and Shc is induced by 12-O-tetradecanoylphorbol 13-acetate treatment, a signaling pathway, PKC-tyrosine kinase-Shc-Ash/Grb2-WASP, is suggested for regulating megakaryocyte differentiation.	Tetradecanoylphorbol Acetate	102-138	SHC adaptor protein 1	Homo sapiens	191-194
9040945-8	1997	Results from these studies suggest that TPA-induced microtubule reorganization is a prerequisite for integrin vesicle translocation in U937 cells and that vesicle translocation to the plasma membrane may be a prerequisite for the transcriptional activation of cd11b and cd11c integrin genes in the early stages of monocyte differentiation.	Tetradecanoylphorbol Acetate	40-43	integrin subunit alpha M	Homo sapiens	260-265
9052738-3	1997	Measles virus and phorbol 12-myristate 13-acetate (PMA) induced MCP-3 mRNA after 6 hr of stimulation.	Tetradecanoylphorbol Acetate	18-49	C-C motif chemokine ligand 7	Homo sapiens	64-69
9052738-3	1997	Measles virus and phorbol 12-myristate 13-acetate (PMA) induced MCP-3 mRNA after 6 hr of stimulation.	Tetradecanoylphorbol Acetate	51-54	C-C motif chemokine ligand 7	Homo sapiens	64-69
21533382-1	1997	Amphiregulin (AR), a new member of the EGF family of ligand, is a glycoprotein containing a 78 or 84 amino acid core polypeptide that was originally purified from the conditioned medium of the breast carcinoma cell line MCF-7 after treatment with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	247-278	amphiregulin	Homo sapiens	0-12
21533382-1	1997	Amphiregulin (AR), a new member of the EGF family of ligand, is a glycoprotein containing a 78 or 84 amino acid core polypeptide that was originally purified from the conditioned medium of the breast carcinoma cell line MCF-7 after treatment with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	247-278	amphiregulin	Homo sapiens	14-16
21533386-4	1997	Raspberry extract (2x15 mg) containing sanguiin H6 and lambertianin D as well as oligomeric procyanidins (2x15 mg) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity by about 30%.	Tetradecanoylphorbol Acetate	123-159	ornithine decarboxylase, structural 1	Mus musculus	174-197
21533386-4	1997	Raspberry extract (2x15 mg) containing sanguiin H6 and lambertianin D as well as oligomeric procyanidins (2x15 mg) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity by about 30%.	Tetradecanoylphorbol Acetate	123-159	ornithine decarboxylase, structural 1	Mus musculus	199-202
21533386-7	1997	Our results su est that hydrolyzable and condensed tannins from various sources, which can inhibit the ODC, HPx, and DNA responses to TPA, might also inhibit the tumor-promoting activity of this agent.	Tetradecanoylphorbol Acetate	134-137	ornithine decarboxylase, structural 1	Mus musculus	103-106
9003041-3	1997	We found that when the active beta from of 4 beta-12-O-tetradecanoylphorbol 13-acetate (TPA), but not the inactive alpha analogue, was incubated in the presence of aFGF, basic FGF, or brain-derived neurotrophic factor, TH expression was initiated.	Tetradecanoylphorbol Acetate	88-91	brain derived neurotrophic factor	Homo sapiens	184-217
8999961-2	1997	In this report, we show that in EL4, a murine T-lymphoma cell line, stimulation with concanavalin A or treatment with phorbol 13-myristate 12-acetate (PMA) inhibit growth, due to cell cycle arrest at both the G1 and the G2/M phases.	Tetradecanoylphorbol Acetate	151-154	epilepsy 4	Mus musculus	32-35
8999961-5	1997	We demonstrate that concanavalin A inhibits cyclin D-Cdk4 activity by decreasing the amount of cyclin D. The inhibition of cyclin E-Cdk2 by both concanavalin A and PMA is due to increased binding of the Cdk inhibitor p21 to this complex.	Tetradecanoylphorbol Acetate	164-167	cyclin-dependent kinase 2	Mus musculus	132-136
8999961-5	1997	We demonstrate that concanavalin A inhibits cyclin D-Cdk4 activity by decreasing the amount of cyclin D. The inhibition of cyclin E-Cdk2 by both concanavalin A and PMA is due to increased binding of the Cdk inhibitor p21 to this complex.	Tetradecanoylphorbol Acetate	164-167	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	217-220
8995230-1	1997	The overexpression of protein kinase C-delta (PKC-delta), but not PKC-epsilon, enables the mouse myeloid cell line 32D to differentiate into macrophages when treated with phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	194-230	protein kinase C, delta	Mus musculus	46-55
8995230-1	1997	The overexpression of protein kinase C-delta (PKC-delta), but not PKC-epsilon, enables the mouse myeloid cell line 32D to differentiate into macrophages when treated with phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	232-235	protein kinase C, delta	Mus musculus	46-55
8995230-5	1997	These are the characteristics of the macrophage phenotype found in TPA-treated 32D cells that overexpressed PKC-delta.	Tetradecanoylphorbol Acetate	67-70	protein kinase C, delta	Mus musculus	108-117
8995230-7	1997	A PKC inhibitor directed toward the catalytic domain of PKC, GF109203X, and a selective inhibitor of PKC-delta, Rottlerin, blocked the TPA-induced differentiation of PKC-epsilon delta-overexpressing 32D cells.	Tetradecanoylphorbol Acetate	135-138	protein kinase C, delta	Mus musculus	2-5
8995230-7	1997	A PKC inhibitor directed toward the catalytic domain of PKC, GF109203X, and a selective inhibitor of PKC-delta, Rottlerin, blocked the TPA-induced differentiation of PKC-epsilon delta-overexpressing 32D cells.	Tetradecanoylphorbol Acetate	135-138	protein kinase C, delta	Mus musculus	101-110
9332699-5	1997	However, linoleic acid and linoleic acid anilide slightly inhibited the phorbol myristate acetate (PMA)-induced expression of CD11b, which was decreased by 27 and 21% at concentrations of 100 and 1000 microM, respectively.	Tetradecanoylphorbol Acetate	72-97	integrin subunit alpha M	Homo sapiens	126-131
9332699-5	1997	However, linoleic acid and linoleic acid anilide slightly inhibited the phorbol myristate acetate (PMA)-induced expression of CD11b, which was decreased by 27 and 21% at concentrations of 100 and 1000 microM, respectively.	Tetradecanoylphorbol Acetate	99-102	integrin subunit alpha M	Homo sapiens	126-131
9192071-3	1997	In contrast, 24 h treatment with the phorbol ester 12-O-tetradecanoylphorbol-3-acetate (TPA) downregulates calbindin-D28K and PKC activity.	Tetradecanoylphorbol Acetate	88-91	protein kinase C alpha	Bos taurus	126-129
9192071-8	1997	Consistent with amino acid sequence analysis of calbindin-D28K indicating two threonine residues that fit the consensus for PKC phosphorylation, TPA-treated MDBK cells exhibit enhanced expression of a phosphothreonine-containing protein that co-migrates with calbindin-D28K.	Tetradecanoylphorbol Acetate	145-148	protein kinase C alpha	Bos taurus	124-127
9067639-5	1997	Downregulation of protein kinase C (PKC) alpha and epsilon isoforms by pretreatment of fibroblasts for 48 h with phorbol 12-myristate 13-acetate (PMA), markedly attenuated both thrombin and PDGF-stimulated p70s6k activation (by 74.8 +/- 4.4% and 82.3 +/- 7.9% respectively).	Tetradecanoylphorbol Acetate	113-144	protein kinase C alpha	Bos taurus	18-46
9067639-5	1997	Downregulation of protein kinase C (PKC) alpha and epsilon isoforms by pretreatment of fibroblasts for 48 h with phorbol 12-myristate 13-acetate (PMA), markedly attenuated both thrombin and PDGF-stimulated p70s6k activation (by 74.8 +/- 4.4% and 82.3 +/- 7.9% respectively).	Tetradecanoylphorbol Acetate	113-144	coagulation factor II, thrombin	Bos taurus	177-185
9067639-5	1997	Downregulation of protein kinase C (PKC) alpha and epsilon isoforms by pretreatment of fibroblasts for 48 h with phorbol 12-myristate 13-acetate (PMA), markedly attenuated both thrombin and PDGF-stimulated p70s6k activation (by 74.8 +/- 4.4% and 82.3 +/- 7.9% respectively).	Tetradecanoylphorbol Acetate	146-149	protein kinase C alpha	Bos taurus	18-46
9067639-5	1997	Downregulation of protein kinase C (PKC) alpha and epsilon isoforms by pretreatment of fibroblasts for 48 h with phorbol 12-myristate 13-acetate (PMA), markedly attenuated both thrombin and PDGF-stimulated p70s6k activation (by 74.8 +/- 4.4% and 82.3 +/- 7.9% respectively).	Tetradecanoylphorbol Acetate	146-149	coagulation factor II, thrombin	Bos taurus	177-185
9039136-3	1997	Angiotensin II (ANG II), endothelin-1 (ET-1), and 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated fourfold to fivefold PKC activity in PKC-alpha cDNA-transfected RTASM cells.	Tetradecanoylphorbol Acetate	50-86	protein kinase C, alpha	Rattus norvegicus	125-128
9039136-3	1997	Angiotensin II (ANG II), endothelin-1 (ET-1), and 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated fourfold to fivefold PKC activity in PKC-alpha cDNA-transfected RTASM cells.	Tetradecanoylphorbol Acetate	50-86	protein kinase C, alpha	Rattus norvegicus	141-150
9039136-3	1997	Angiotensin II (ANG II), endothelin-1 (ET-1), and 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated fourfold to fivefold PKC activity in PKC-alpha cDNA-transfected RTASM cells.	Tetradecanoylphorbol Acetate	88-91	protein kinase C, alpha	Rattus norvegicus	125-128
9039136-3	1997	Angiotensin II (ANG II), endothelin-1 (ET-1), and 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated fourfold to fivefold PKC activity in PKC-alpha cDNA-transfected RTASM cells.	Tetradecanoylphorbol Acetate	88-91	protein kinase C, alpha	Rattus norvegicus	141-150
9218534-6	1997	Since the co-expression with a dominant negative c-Fos abolished the responsiveness to TPA, we conclude that activated transcription of the DRA gene depends on interactions between the X2 box and NF-X2, which contains c-Fos.	Tetradecanoylphorbol Acetate	87-90	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	218-223
9591190-4	1997	It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU).	Tetradecanoylphorbol Acetate	16-52	ornithine decarboxylase, structural 1	Mus musculus	124-147
9591190-4	1997	It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU).	Tetradecanoylphorbol Acetate	16-52	ornithine decarboxylase, structural 1	Mus musculus	149-152
9591190-4	1997	It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU).	Tetradecanoylphorbol Acetate	16-52	ornithine decarboxylase, structural 1	Mus musculus	166-169
9591190-4	1997	It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU).	Tetradecanoylphorbol Acetate	54-57	ornithine decarboxylase, structural 1	Mus musculus	124-147
9591190-4	1997	It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU).	Tetradecanoylphorbol Acetate	54-57	ornithine decarboxylase, structural 1	Mus musculus	149-152
8988173-5	1997	In a search for cellular factors that could activate p21 during phorbol ester (TPA)-induced differentiation, we identified AP2 as a regulator of p21 expression.	Tetradecanoylphorbol Acetate	79-82	transcription factor AP-2 alpha	Homo sapiens	123-126
9633822-0	1997	Fibroblast growth factor-2 and TPA enhance prostate-cancer-cell proliferation and activate members of the Ras and PKC signal transduction pathways.	Tetradecanoylphorbol Acetate	31-34	protein kinase C, alpha	Rattus norvegicus	114-117
9633822-5	1997	Antisense-FGF-1 transfectant doubling-time was 2.2-fold greater than that of vector-control transfectants and was reduced 2.0- or 2.3-fold, respectively, when these cells were cultured in medium containing FGF-2 or TPA.	Tetradecanoylphorbol Acetate	215-218	fibroblast growth factor 1	Rattus norvegicus	10-15
9286030-4	1997	Of the various cytokines, tumor necrosis factor alpha (TNF alpha), interferon-gamma (IFN gamma), and phorbol myristate acetate (PMA) strongly upregulated ICAM-1 protein expression on RCC.	Tetradecanoylphorbol Acetate	101-126	intercellular adhesion molecule 1	Homo sapiens	154-160
9286030-4	1997	Of the various cytokines, tumor necrosis factor alpha (TNF alpha), interferon-gamma (IFN gamma), and phorbol myristate acetate (PMA) strongly upregulated ICAM-1 protein expression on RCC.	Tetradecanoylphorbol Acetate	128-131	intercellular adhesion molecule 1	Homo sapiens	154-160
8962141-8	1996	Stimulation with phorbol 12-myristate 13-acetate increased both surface and total CD68 expression considerably.	Tetradecanoylphorbol Acetate	17-48	CD68 molecule	Homo sapiens	82-86
9006088-0	1996	Quantitation of early clonal expansion of two mutant 61st codon c-Ha-ras alleles in DMBA/TPA treated mouse skin by nested PCR/RFLP.	Tetradecanoylphorbol Acetate	89-92	Harvey rat sarcoma virus oncogene	Mus musculus	64-72
9006114-6	1996	Four of these were unique codon 13 GGC --&gt; GTC changes, significantly different from the DMBA group and from historical TPA-only controls.	Tetradecanoylphorbol Acetate	123-126	gamma-glutamyl cyclotransferase	Mus musculus	35-38
8973627-4	1996	The CD4+CD7- subpopulation was found to secrete significantly higher levels of IL-5 compared with the CD4+CD7- subset upon stimulation with ionomycin/phorbol myristate acetate (PMA) plus anti-CD28 MoAbs.	Tetradecanoylphorbol Acetate	150-175	CD7 molecule	Homo sapiens	8-11
8973627-4	1996	The CD4+CD7- subpopulation was found to secrete significantly higher levels of IL-5 compared with the CD4+CD7- subset upon stimulation with ionomycin/phorbol myristate acetate (PMA) plus anti-CD28 MoAbs.	Tetradecanoylphorbol Acetate	177-180	CD7 molecule	Homo sapiens	8-11
8977524-7	1996	A23187, which synergizes with PMA in the induction of IL-4 and IFN-gamma, inhibited PMA-induced IL-10 production in a dose-dependent manner.	Tetradecanoylphorbol Acetate	30-33	interleukin 10	Homo sapiens	96-101
8977524-7	1996	A23187, which synergizes with PMA in the induction of IL-4 and IFN-gamma, inhibited PMA-induced IL-10 production in a dose-dependent manner.	Tetradecanoylphorbol Acetate	84-87	interleukin 10	Homo sapiens	96-101
9423851-3	1998	After 18 and 48 h of treatment with IL-15, human elutriated monocytes manifested enhanced superoxide production in response to either phorbol myristate acetate or opsonized Candida albicans blastoconidia.	Tetradecanoylphorbol Acetate	134-159	interleukin 15	Homo sapiens	36-41
10195234-7	1998	In U937 cells, TNF-alpha and phorbol myristate acetate (PMA) stimulated CXCR4 gene transcription; this effect was reversed with prior treatment of cells with IFN-gamma.	Tetradecanoylphorbol Acetate	29-54	C-X-C motif chemokine receptor 4	Homo sapiens	72-77
10195234-7	1998	In U937 cells, TNF-alpha and phorbol myristate acetate (PMA) stimulated CXCR4 gene transcription; this effect was reversed with prior treatment of cells with IFN-gamma.	Tetradecanoylphorbol Acetate	56-59	C-X-C motif chemokine receptor 4	Homo sapiens	72-77
9388272-5	1997	272, 31172-31181), we demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment of Fao cells induces tyrosine phosphorylation of several proteins including ErbB2 and ErbB3.	Tetradecanoylphorbol Acetate	73-76	erb-b2 receptor tyrosine kinase 2	Rattus norvegicus	164-169
9489948-0	1997	Semiquantitative PCR of alpha2 and alpha4 integrin mRNA shows differential response to the transcriptional modulators TGF-beta1 and TPA.	Tetradecanoylphorbol Acetate	132-135	immunoglobulin binding protein 1	Homo sapiens	35-41
21528341-5	1997	More specifically, we observed: (a) increased secretion and/or activation of gelatinases A (MMP-2) and B (MMP-9) after exposure of 8 cell lines to 10(-6) M TPA; (b) increased activation of interstitial collagenase (MMP-1) caseinolysis after stimulation of 3 cancer cell lines with 10(-7) M TPA; and (c) increased activation of MMP-2 after exposure of 2 cell lines to 0.5 mM H3O2.	Tetradecanoylphorbol Acetate	156-159	matrix metallopeptidase 9	Homo sapiens	103-111
9369952-5	1997	In contrast, depletion of cellular protein kinase C (PKC) with phorbol-12-myristate 13-acetate (0.01 microM for 20 hr) increased both BK- and alpha-T-induced phosphoinositide turnover but inhibited the agonist-induced increase in permeability.	Tetradecanoylphorbol Acetate	63-94	kininogen 1	Bos taurus	134-136
9487993-9	1997	In cultured Cushing"s adenoma cells, adrenocorticotropin, dibutyryl cAMP ((Bu)2cAMP) and staurosporine inhibited the accumulation of ADM mRNA by 40, 50 and 70% respectively (P &lt; 0.05), whereas the protein kinase C activator, 12-O-tetradecanoyl phorbol 13-acetate (TPA), increased it by 50% (P &lt; 0.05).	Tetradecanoylphorbol Acetate	228-265	adrenomedullin	Homo sapiens	133-136
9487993-9	1997	In cultured Cushing"s adenoma cells, adrenocorticotropin, dibutyryl cAMP ((Bu)2cAMP) and staurosporine inhibited the accumulation of ADM mRNA by 40, 50 and 70% respectively (P &lt; 0.05), whereas the protein kinase C activator, 12-O-tetradecanoyl phorbol 13-acetate (TPA), increased it by 50% (P &lt; 0.05).	Tetradecanoylphorbol Acetate	267-270	adrenomedullin	Homo sapiens	133-136
9409785-0	1997	Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2.	Tetradecanoylphorbol Acetate	59-62	ETS variant transcription factor 4	Homo sapiens	19-23
9409785-0	1997	Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2.	Tetradecanoylphorbol Acetate	59-62	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	24-27
9353342-5	1997	SDF-1 and phorbol 12-myristate 13-acetate (PMA), but not a membrane permeable cAMP analog induced rapid phosphorylation as well as desensitization of Wt CXCR4.	Tetradecanoylphorbol Acetate	10-41	C-X-C motif chemokine receptor 4	Homo sapiens	153-158
9353342-5	1997	SDF-1 and phorbol 12-myristate 13-acetate (PMA), but not a membrane permeable cAMP analog induced rapid phosphorylation as well as desensitization of Wt CXCR4.	Tetradecanoylphorbol Acetate	43-46	C-X-C motif chemokine receptor 4	Homo sapiens	153-158
9353342-9	1997	PMA completely inhibited phosphoinositide hydrolysis and calcium mobilization in Wt CXCR4 but only partially inhibited these responses in DeltaCyto CXCR4.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine receptor 4	Homo sapiens	84-89
9353342-9	1997	PMA completely inhibited phosphoinositide hydrolysis and calcium mobilization in Wt CXCR4 but only partially inhibited these responses in DeltaCyto CXCR4.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine receptor 4	Homo sapiens	148-153
9374728-6	1997	BBEC primary cultures treated with either 500 U/ml TNF-alpha for 2-4 h or 100 ng/ml 12-O-tetradecanoylphorbol 13-acetate for 15 min resulted in three-to fivefold increases in PKC activity in the particulate fractions of crude cell lysates.	Tetradecanoylphorbol Acetate	84-120	protein kinase C alpha	Bos taurus	175-178
9348199-7	1997	Also, the cell-permeable, myristoylated PKC-zeta pseudosubstrate inhibited insulin-stimulated glucose transport both in non-down-regulated and PKC-depleted (TPA-treated) L6 myotubes; thus, the PKC-zeta pseudosubstrate appeared to inhibit a protein kinase that is required for insulin-stimulated glucose transport but is distinct from DAG-sensitive PKCs.	Tetradecanoylphorbol Acetate	157-160	protein kinase C zeta	Homo sapiens	40-48
9348199-7	1997	Also, the cell-permeable, myristoylated PKC-zeta pseudosubstrate inhibited insulin-stimulated glucose transport both in non-down-regulated and PKC-depleted (TPA-treated) L6 myotubes; thus, the PKC-zeta pseudosubstrate appeared to inhibit a protein kinase that is required for insulin-stimulated glucose transport but is distinct from DAG-sensitive PKCs.	Tetradecanoylphorbol Acetate	157-160	protein kinase C, beta	Rattus norvegicus	40-43
9348199-7	1997	Also, the cell-permeable, myristoylated PKC-zeta pseudosubstrate inhibited insulin-stimulated glucose transport both in non-down-regulated and PKC-depleted (TPA-treated) L6 myotubes; thus, the PKC-zeta pseudosubstrate appeared to inhibit a protein kinase that is required for insulin-stimulated glucose transport but is distinct from DAG-sensitive PKCs.	Tetradecanoylphorbol Acetate	157-160	protein kinase C zeta	Homo sapiens	193-201
9427286-7	1997	An activator of protein kinase C (PKCs), 12-O-tetradecanoyl phorbol 13-acetate (TPA), abolishes the up-regulation of myf5 gene expression by dexamethasone and anisomycin, and its effect is counteracted by an inhibitor of PKCs, GF 109203X.	Tetradecanoylphorbol Acetate	41-78	myogenic factor 5	Mus musculus	117-121
9427286-7	1997	An activator of protein kinase C (PKCs), 12-O-tetradecanoyl phorbol 13-acetate (TPA), abolishes the up-regulation of myf5 gene expression by dexamethasone and anisomycin, and its effect is counteracted by an inhibitor of PKCs, GF 109203X.	Tetradecanoylphorbol Acetate	80-83	myogenic factor 5	Mus musculus	117-121
9341140-4	1997	Reporter gene assays also demonstrated that gastrin and PMA stimulated Elk-1- and c-Myc-dependent transactivation, consistent with gastrin- and PMA-induced activation of ERKs.	Tetradecanoylphorbol Acetate	56-59	ETS transcription factor ELK1	Homo sapiens	71-76
9341140-4	1997	Reporter gene assays also demonstrated that gastrin and PMA stimulated Elk-1- and c-Myc-dependent transactivation, consistent with gastrin- and PMA-induced activation of ERKs.	Tetradecanoylphorbol Acetate	144-147	ETS transcription factor ELK1	Homo sapiens	71-76
9353133-2	1997	Phorbol ester (PMA), added to stimulate phosphorylation of P-gp by protein kinase C (PKC), caused a decrease in the cellular accumulation of DNR and VP-16, both in multidrug-resistant (MDR) P-gp-overexpressing cells and in wild-type cells.	Tetradecanoylphorbol Acetate	15-18	host cell factor C1	Homo sapiens	149-154
9317111-3	1997	In these experiments using CD8+ alloreactive cell lines, we demonstrate that induction of FasL mRNA can occur in response to either PMA or ionomycin independently.	Tetradecanoylphorbol Acetate	132-135	CD8a molecule	Homo sapiens	27-30
9300179-0	1997	c-sis/platelet-derived growth factor-B promoter requirements for induction during the 12-O-tetradecanoylphorbol-13-acetate-mediated megakaryoblastic differentiation of K562 human erythroleukemia cells.	Tetradecanoylphorbol Acetate	86-122	platelet derived growth factor subunit B	Homo sapiens	0-5
9300179-2	1997	We have studied the transcriptional regulation of the c-sis/PDGF-B gene in human K562 erythroleukemia cells that have been induced to undergo megakaryoblastic differentiation by treatment with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	193-229	platelet derived growth factor subunit B	Homo sapiens	54-59
9300179-2	1997	We have studied the transcriptional regulation of the c-sis/PDGF-B gene in human K562 erythroleukemia cells that have been induced to undergo megakaryoblastic differentiation by treatment with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	193-229	platelet derived growth factor subunit B	Homo sapiens	60-66
9300179-11	1997	The TNS, therefore, appears to represent a target for a constitutively bound factor(s) that is required for cooperation with a differentiation-specific factor bound at the SPE to drive efficient c-sis/PDGF-B transcription in TPA-treated K562 cells.	Tetradecanoylphorbol Acetate	225-228	platelet derived growth factor subunit B	Homo sapiens	195-200
9300179-11	1997	The TNS, therefore, appears to represent a target for a constitutively bound factor(s) that is required for cooperation with a differentiation-specific factor bound at the SPE to drive efficient c-sis/PDGF-B transcription in TPA-treated K562 cells.	Tetradecanoylphorbol Acetate	225-228	platelet derived growth factor subunit B	Homo sapiens	201-207
8952699-0	1996	Characterization of a novel amphiregulin-related molecule in 12-O-tetradecanoylphorbol-13-acetate-treated breast cancer cells.	Tetradecanoylphorbol Acetate	61-97	amphiregulin	Homo sapiens	28-40
8952699-1	1996	Amphiregulin (AR) can be induced at the mRNA level by 17-beta-estradiol (E2) or the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	113-149	amphiregulin	Homo sapiens	0-12
8952699-1	1996	Amphiregulin (AR) can be induced at the mRNA level by 17-beta-estradiol (E2) or the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	113-149	amphiregulin	Homo sapiens	14-16
8952699-1	1996	Amphiregulin (AR) can be induced at the mRNA level by 17-beta-estradiol (E2) or the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	151-154	amphiregulin	Homo sapiens	0-12
8952699-1	1996	Amphiregulin (AR) can be induced at the mRNA level by 17-beta-estradiol (E2) or the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	151-154	amphiregulin	Homo sapiens	14-16
8952699-2	1996	This study compares the effects of TPA and E2 on the regulation of processing of AR isoforms and on subcellular localization in human MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	35-38	amphiregulin	Homo sapiens	81-83
9368670-5	1997	By contrast, apoptosis induced by VP-16 in CCRF-CEM cells was attenuated by the addition of 0.5 microM phorbol 12-myristate 13-acetate, a potent PKC stimulator.	Tetradecanoylphorbol Acetate	103-134	host cell factor C1	Homo sapiens	34-39
8952699-4	1996	AR isoforms of 28, 18, and 10 kDa and an additional species of approximately 55-60 kDa were detected in the cellular conditioned media after TPA stimulation.	Tetradecanoylphorbol Acetate	141-144	amphiregulin	Homo sapiens	0-2
3008983-6	1986	Because retinoids do not directly affect TPA binding to PK-C, the data suggest that (i) the presence of retinoic acid results in the exposure of heretofore cryptic TPA-binding sites in the membrane, where this binding is most likely related to the alteration of membrane structure and (ii) de novo ODC induction is not required for retinoid-dependent inhibition of PK-C, although the TPA induction of PK-C appears to be necessary with regard to ODC induction.	Tetradecanoylphorbol Acetate	164-167	ornithine decarboxylase, structural 1	Mus musculus	298-301
8952699-9	1996	These data suggest that TPA activation of PKC may be involved in post-translational modifications of AR, such as glycosylation, and in alteration of its subcellular routing to predominantly a secretory pathway.	Tetradecanoylphorbol Acetate	24-27	amphiregulin	Homo sapiens	101-103
8970984-7	1996	However, the TPA responsiveness of both CMV elements proved to involve synergistic interactions between the core SRF binding site (CCATATATGG) and the adjacent inverted ETS binding motifs (TTCC), which correlated directly with formation of a bound tripartite complex containing both the cellular SRF and ELK-1 proteins.	Tetradecanoylphorbol Acetate	13-16	serum response factor	Homo sapiens	113-116
8970984-7	1996	However, the TPA responsiveness of both CMV elements proved to involve synergistic interactions between the core SRF binding site (CCATATATGG) and the adjacent inverted ETS binding motifs (TTCC), which correlated directly with formation of a bound tripartite complex containing both the cellular SRF and ELK-1 proteins.	Tetradecanoylphorbol Acetate	13-16	serum response factor	Homo sapiens	296-299
8970984-7	1996	However, the TPA responsiveness of both CMV elements proved to involve synergistic interactions between the core SRF binding site (CCATATATGG) and the adjacent inverted ETS binding motifs (TTCC), which correlated directly with formation of a bound tripartite complex containing both the cellular SRF and ELK-1 proteins.	Tetradecanoylphorbol Acetate	13-16	ETS transcription factor ELK1	Homo sapiens	304-309
9350434-2	1997	Since these latter compounds were known to activate NF-kappa B translocation in a redox-sensitive way, we have demonstrated that NF-kappa B activation by PMA was resistant to antioxidant N-acetyl-L-cysteine (NAC) and sensitive to kinase inhibitors staurosporine and H7 while activation by H2O2 or TNF-alpha were not.	Tetradecanoylphorbol Acetate	154-157	X-linked Kx blood group	Homo sapiens	208-211
9328442-13	1997	Therefore, under these tandem conditions, tumor yields were additive, indicating that there are at least two distinct populations of mutant Ha-ras cells: one promoted by mirex and the other by TPA.	Tetradecanoylphorbol Acetate	193-196	Harvey rat sarcoma virus oncogene	Mus musculus	140-146
9270009-8	1997	Moreover, inhibition of this enzyme correlated with a rapid depletion of ATP levels and potential to inhibit either TPA- or c-Myc-induced ODC activity.	Tetradecanoylphorbol Acetate	116-119	ornithine decarboxylase, structural 1	Mus musculus	138-141
9270011-6	1997	In this study, we present evidence that RME can down-regulate AP-1 activity induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate, insulin, growth factors, and the nuclear proto-oncogenes c-Jun and c-Fos.	Tetradecanoylphorbol Acetate	106-142	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	62-66
9270011-9	1997	Furthermore, using gel retardation assay, we show that 12-O-tetradecanoylphorbol-13-acetate- and epidermal growth factor-induced AP-1 binding activity in breast cancer cells is inhibited by RME.	Tetradecanoylphorbol Acetate	55-91	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	129-133
3008983-6	1986	Because retinoids do not directly affect TPA binding to PK-C, the data suggest that (i) the presence of retinoic acid results in the exposure of heretofore cryptic TPA-binding sites in the membrane, where this binding is most likely related to the alteration of membrane structure and (ii) de novo ODC induction is not required for retinoid-dependent inhibition of PK-C, although the TPA induction of PK-C appears to be necessary with regard to ODC induction.	Tetradecanoylphorbol Acetate	164-167	ornithine decarboxylase, structural 1	Mus musculus	445-448
9242432-1	1997	Asbestos and the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), increase c-fos and c-jun mRNA levels and AP-1 DNA binding activity in rat pleural mesothelial (RPM) cells, a target cell of asbestos-induced mesotheliomas (N. H. Heintz et al., Proc.	Tetradecanoylphorbol Acetate	47-83	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	100-105
3008983-6	1986	Because retinoids do not directly affect TPA binding to PK-C, the data suggest that (i) the presence of retinoic acid results in the exposure of heretofore cryptic TPA-binding sites in the membrane, where this binding is most likely related to the alteration of membrane structure and (ii) de novo ODC induction is not required for retinoid-dependent inhibition of PK-C, although the TPA induction of PK-C appears to be necessary with regard to ODC induction.	Tetradecanoylphorbol Acetate	164-167	ornithine decarboxylase, structural 1	Mus musculus	298-301
9242432-1	1997	Asbestos and the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), increase c-fos and c-jun mRNA levels and AP-1 DNA binding activity in rat pleural mesothelial (RPM) cells, a target cell of asbestos-induced mesotheliomas (N. H. Heintz et al., Proc.	Tetradecanoylphorbol Acetate	85-88	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	100-105
3008983-6	1986	Because retinoids do not directly affect TPA binding to PK-C, the data suggest that (i) the presence of retinoic acid results in the exposure of heretofore cryptic TPA-binding sites in the membrane, where this binding is most likely related to the alteration of membrane structure and (ii) de novo ODC induction is not required for retinoid-dependent inhibition of PK-C, although the TPA induction of PK-C appears to be necessary with regard to ODC induction.	Tetradecanoylphorbol Acetate	164-167	ornithine decarboxylase, structural 1	Mus musculus	445-448
2936810-1	1986	Phorbol myristate acetate (PMA) exerts a biphasic effect on receptors for C3b and C3bi of human polymorphonuclear leukocytes (PMN).	Tetradecanoylphorbol Acetate	0-25	complement C3	Homo sapiens	74-77
9231795-3	1997	Both Ca2+-dependent and -independent PKC activity appear equally inhibited by aldosterone, and PMA-stimulated increases in PKC activity appear similarly aldosterone-sensitive.	Tetradecanoylphorbol Acetate	95-98	protein kinase C, gamma	Rattus norvegicus	123-126
9600114-0	1997	12-O-tetradecanoylphorbol-13-acetate (TPA) downregulates expression of CD30 in erythroleukemia cell line K562.	Tetradecanoylphorbol Acetate	0-36	TNF receptor superfamily member 8	Homo sapiens	71-75
9600114-0	1997	12-O-tetradecanoylphorbol-13-acetate (TPA) downregulates expression of CD30 in erythroleukemia cell line K562.	Tetradecanoylphorbol Acetate	38-41	TNF receptor superfamily member 8	Homo sapiens	71-75
9600114-3	1997	In this study, modulation of the CD30 molecule was investigated by the treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	86-123	TNF receptor superfamily member 8	Homo sapiens	33-37
9600114-3	1997	In this study, modulation of the CD30 molecule was investigated by the treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	125-128	TNF receptor superfamily member 8	Homo sapiens	33-37
8943323-8	1996	Here we show that 3pK is activated in vivo by the growth inducers serum and tetradecanoyl phorbol acetate in promyelocytic HL60 cells and transiently transfected embryonic kidney 293 cells.	Tetradecanoylphorbol Acetate	76-105	MAPK activated protein kinase 3	Homo sapiens	18-21
8906745-4	1996	Our work demonstrates that: (1) resting B cells from mice containing the Yaa allele hyperproliferated compared to that seen with B cells from mice lacking the Yaa allele, (2) this hyperproliferation occurred whether cells were stimulated with phorbol myristate acetate/ionomycin, LPS, anti-IgM, or CD40L cross-linking, (3) this hyperproliferation is specific to B and not T cells.	Tetradecanoylphorbol Acetate	243-268	accelerated autoimmunity and lymphoproliferation transposition	Mus musculus	73-76
9600114-4	1997	When cultures were supplemented with TPA, CD30 transcript was downregulated in a dose- and time-dependent manner in the erythroleukemia cell line K562.	Tetradecanoylphorbol Acetate	37-40	TNF receptor superfamily member 8	Homo sapiens	42-46
2936810-1	1986	Phorbol myristate acetate (PMA) exerts a biphasic effect on receptors for C3b and C3bi of human polymorphonuclear leukocytes (PMN).	Tetradecanoylphorbol Acetate	27-30	complement C3	Homo sapiens	74-77
9600114-6	1997	This consecutive reduction of both the transcript and proteins suggests that TPA directly inhibits the transcriptional step of CD30, and subsequently CD30 molecules would decrease on the cell surface.	Tetradecanoylphorbol Acetate	77-80	TNF receptor superfamily member 8	Homo sapiens	127-131
9600114-6	1997	This consecutive reduction of both the transcript and proteins suggests that TPA directly inhibits the transcriptional step of CD30, and subsequently CD30 molecules would decrease on the cell surface.	Tetradecanoylphorbol Acetate	77-80	TNF receptor superfamily member 8	Homo sapiens	150-154
9600114-8	1997	The addition of H-7 recovered the inhibitory effect of TPA, indicating that PKC is involved in the transcription of CD30.	Tetradecanoylphorbol Acetate	55-58	TNF receptor superfamily member 8	Homo sapiens	116-120
9600114-9	1997	When either 2 micrograms/ml actinomycin D or 20 micrograms/ml cycloheximide was added simultaneously with TPA to the culture, the repressive effect of TPA on CD30 was abolished.	Tetradecanoylphorbol Acetate	106-109	TNF receptor superfamily member 8	Homo sapiens	158-162
9600114-9	1997	When either 2 micrograms/ml actinomycin D or 20 micrograms/ml cycloheximide was added simultaneously with TPA to the culture, the repressive effect of TPA on CD30 was abolished.	Tetradecanoylphorbol Acetate	151-154	TNF receptor superfamily member 8	Homo sapiens	158-162
9047076-0	1996	Modulation of levels of a negative transcription factor for IL-2 by 12-O-tetradecanoyl phorbol-13-acetate and okadaic acid.	Tetradecanoylphorbol Acetate	68-105	interleukin 2	Bos taurus	60-64
9047076-7	1996	Because exposure of lymphocytes to either OKA or TPA should lead to an increase in the phosphorylation and binding of the NREA protein, and a decrease in IL-2 production, proliferation should be decreased.	Tetradecanoylphorbol Acetate	49-52	interleukin 2	Bos taurus	154-158
9047076-9	1996	However, the mechanisms of action of OKA and TPA appeared to be different because exogenous IL-2 reversed the inhibition of proliferation caused by TPA but not by OKA.	Tetradecanoylphorbol Acetate	45-48	interleukin 2	Bos taurus	92-96
9047076-9	1996	However, the mechanisms of action of OKA and TPA appeared to be different because exogenous IL-2 reversed the inhibition of proliferation caused by TPA but not by OKA.	Tetradecanoylphorbol Acetate	148-151	interleukin 2	Bos taurus	92-96
3457877-10	1986	The coefficients of correlations between CA125 and other tumor markers are as follows: IAP 0.5268, TPA 0.4541, HBDH 0.4551, CEA 0.2942, Ferritin -0.1005, alpha 1AT 0.5321, ESR -0.0619, LDH 0.5994.	Tetradecanoylphorbol Acetate	99-102	mucin 16, cell surface associated	Homo sapiens	41-46
9234942-5	1997	Only the lytic LMP-1 protein is present in BJAB cells early (within minutes following addition of virus) after infection with virus derived from either uninduced or tetradecanoyl phorbol acetate and sodium butyrate-induced B958 cells.	Tetradecanoylphorbol Acetate	165-194	PDZ and LIM domain 7	Homo sapiens	15-20
3081271-0	1986	Effects of lipoxygenase and cyclooxygenase inhibitors on the induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate and isoproterenol in mouse tissues in vivo.	Tetradecanoylphorbol Acetate	101-137	ornithine decarboxylase, structural 1	Mus musculus	74-97
9252557-5	1997	316: 943-951, 1996) secreted mucin on exposure to phorbol 12-myristate 13-acetate (PMA) [apparent affinity (K0.5) approximately 100 nM] and ionomycin (K0.5 approximately 5 microM) almost fivefold over baseline.	Tetradecanoylphorbol Acetate	50-81	solute carrier family 13 member 2	Rattus norvegicus	29-34
9252557-5	1997	316: 943-951, 1996) secreted mucin on exposure to phorbol 12-myristate 13-acetate (PMA) [apparent affinity (K0.5) approximately 100 nM] and ionomycin (K0.5 approximately 5 microM) almost fivefold over baseline.	Tetradecanoylphorbol Acetate	83-86	solute carrier family 13 member 2	Rattus norvegicus	29-34
8931867-2	1996	Tacalcitol was shown to inhibit epidermal proliferation using TPA-induced ornithine decarboxylase activity and DNA synthesis as indices, and the induction of epidermal differentiation using type I transglutaminase activity as an index.	Tetradecanoylphorbol Acetate	62-65	ornithine decarboxylase, structural 1	Mus musculus	74-97
3081271-2	1986	administration of 12-O-tetradecanoylphorbol-13-acetate (TPA) (400 micrograms/kg) caused a remarkable increase in ornithine decarboxylase (ODC) activity in CD-1 mouse liver (8.3-fold), spleen (17.8-fold), kidney (4-fold), lung (7.7-fold) and brain (2.7-fold).	Tetradecanoylphorbol Acetate	18-54	ornithine decarboxylase, structural 1	Mus musculus	113-136
8828483-7	1996	Phorbol myristate acetate, an activator of protein kinase C, mimicked the effects of bFGF and TGF alpha.	Tetradecanoylphorbol Acetate	0-25	transforming growth factor alpha	Rattus norvegicus	94-103
9202234-11	1997	The pattern of steroid responses was retained in the presence of the c-Jun activator phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	85-116	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-74
3081271-2	1986	administration of 12-O-tetradecanoylphorbol-13-acetate (TPA) (400 micrograms/kg) caused a remarkable increase in ornithine decarboxylase (ODC) activity in CD-1 mouse liver (8.3-fold), spleen (17.8-fold), kidney (4-fold), lung (7.7-fold) and brain (2.7-fold).	Tetradecanoylphorbol Acetate	18-54	ornithine decarboxylase, structural 1	Mus musculus	138-141
8828483-8	1996	Interestingly, long term (24-h) pretreatment with phorbol myristate acetate resulted in a severe loss of responsiveness to bFGF or TGF alpha.	Tetradecanoylphorbol Acetate	50-75	transforming growth factor alpha	Rattus norvegicus	131-140
3081271-2	1986	administration of 12-O-tetradecanoylphorbol-13-acetate (TPA) (400 micrograms/kg) caused a remarkable increase in ornithine decarboxylase (ODC) activity in CD-1 mouse liver (8.3-fold), spleen (17.8-fold), kidney (4-fold), lung (7.7-fold) and brain (2.7-fold).	Tetradecanoylphorbol Acetate	56-59	ornithine decarboxylase, structural 1	Mus musculus	113-136
9121495-5	1996	TPA stimulation of the human GnRH gene is mediated by a consensus AP-1 site located at -402 to -396 bp, TGACTCA, which specifically binds c-fos and c-jun in Gn11 and NLT cells and recombinant c-jun in gel mobility shift studies.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	148-153
3081271-2	1986	administration of 12-O-tetradecanoylphorbol-13-acetate (TPA) (400 micrograms/kg) caused a remarkable increase in ornithine decarboxylase (ODC) activity in CD-1 mouse liver (8.3-fold), spleen (17.8-fold), kidney (4-fold), lung (7.7-fold) and brain (2.7-fold).	Tetradecanoylphorbol Acetate	56-59	ornithine decarboxylase, structural 1	Mus musculus	138-141
9121495-5	1996	TPA stimulation of the human GnRH gene is mediated by a consensus AP-1 site located at -402 to -396 bp, TGACTCA, which specifically binds c-fos and c-jun in Gn11 and NLT cells and recombinant c-jun in gel mobility shift studies.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	192-197
3081271-3	1986	TPA induced an increase in ODC activity in liver, spleen and kidney in a dose-dependent manner (100-800 micrograms/kg).	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	27-30
3081271-5	1986	BW755C, an inhibitor of cyclooxygenase and lipoxygenase, prevented the TPA-induced increase in ODC activity in liver, spleen and kidney in a dose-dependent manner.	Tetradecanoylphorbol Acetate	71-74	ornithine decarboxylase, structural 1	Mus musculus	95-98
8887449-3	1996	When EL-4 thymoma cells were stimulated with phorbol 12-myristate 13-acetate plus ionomycin in the presence of 500 ng/ml VT, DNA binding activity by NF-kappaB/Rel in nuclear extracts was increased from 2 to 48 hr when compared to controls employing no VT. VT preferentially induced a slower migrating electrophoretic band of the NF-kappaB/Rel complex particularly in later time points (8-48 hr).	Tetradecanoylphorbol Acetate	45-76	epilepsy 4	Mus musculus	5-9
9247590-3	1997	We report that the mutation of S126 in the CD3-gamma chain that is known to inhibit phorbol-12-myristate 13-acetate-induced TCR down-regulation does not affect down-regulation induced by a specific agonist.	Tetradecanoylphorbol Acetate	84-115	CD3 gamma subunit of T-cell receptor complex	Homo sapiens	43-52
3081271-6	1986	AA861-a selective lipoxygenase inhibitor, also showed the inhibition of TPA-induced increase in ODC activity in these tissues.	Tetradecanoylphorbol Acetate	72-75	ornithine decarboxylase, structural 1	Mus musculus	96-99
9254887-9	1997	However, the combination of substantial levels of mRNA for stromelysin-1, stromelysin-2, collagenase, membrane type 1 MMP, and gelatinase A occurred only in TPA-treated cells in the absence of TAM67.	Tetradecanoylphorbol Acetate	157-160	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	102-121
9254887-9	1997	However, the combination of substantial levels of mRNA for stromelysin-1, stromelysin-2, collagenase, membrane type 1 MMP, and gelatinase A occurred only in TPA-treated cells in the absence of TAM67.	Tetradecanoylphorbol Acetate	157-160	matrix metallopeptidase 2	Mus musculus	127-139
9190898-1	1997	While the standard form of CD44 was expressed at high levels in both treated and untreated cells, variant isoforms were strongly upregulated in response to treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA), insulin-like growth factor-1 (IGF-1) and platelet-derived growth factor (PDGF) as shown by RT-PCR and immunofluorescence.	Tetradecanoylphorbol Acetate	171-208	CD44 molecule (Indian blood group)	Homo sapiens	27-31
8790149-8	1996	Coexpression of CD7 was detected on 8.7-34.5% (mean 17.3%) of this CD 13/33+ cell population, but it was induced to decrease significantly after short-term in vitro culture with the differentiation-inducing agent phorbol ester (TPA).	Tetradecanoylphorbol Acetate	228-231	CD7 molecule	Homo sapiens	16-19
3081271-8	1986	On the other hand, indomethacin, a selective cyclooxygenase inhibitor, enhanced the TPA-induced increase in ODC activity in these tissues dose-dependently.	Tetradecanoylphorbol Acetate	84-87	ornithine decarboxylase, structural 1	Mus musculus	108-111
9190898-1	1997	While the standard form of CD44 was expressed at high levels in both treated and untreated cells, variant isoforms were strongly upregulated in response to treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA), insulin-like growth factor-1 (IGF-1) and platelet-derived growth factor (PDGF) as shown by RT-PCR and immunofluorescence.	Tetradecanoylphorbol Acetate	210-213	CD44 molecule (Indian blood group)	Homo sapiens	27-31
9190898-6	1997	The induction of CD44V by TPA, IGF-1 or PDGF was correlated with an increased cellular binding to hyaluronic acid, a major counterreceptor for CD44.	Tetradecanoylphorbol Acetate	26-29	CD44 molecule (Indian blood group)	Homo sapiens	17-21
3081271-12	1986	These results indicate that product(s) of lipoxygenase pathway play an important role in ODC induction caused by TPA in liver, spleen and kidney, while the lipoxygenase pathway does not play an essential role in the isoproterenol-induced increase in ODC activity.	Tetradecanoylphorbol Acetate	113-116	ornithine decarboxylase, structural 1	Mus musculus	89-92
9190898-6	1997	The induction of CD44V by TPA, IGF-1 or PDGF was correlated with an increased cellular binding to hyaluronic acid, a major counterreceptor for CD44.	Tetradecanoylphorbol Acetate	26-29	CD44 molecule (Indian blood group)	Homo sapiens	143-147
8790149-11	1996	The fact that CD7 expression tended to be lost after TPA stimulation suggested that CD7 was transiently expressed in early myeloid differentiation.	Tetradecanoylphorbol Acetate	53-56	CD7 molecule	Homo sapiens	84-87
3002350-4	1985	The combination of A23187 and TPA stimulated ANP secretion higher than the calculated additive value for each agent.	Tetradecanoylphorbol Acetate	30-33	natriuretic peptide A	Rattus norvegicus	45-48
4054128-4	1985	In resting PMN and in PMN activated by phorbol myristate acetate (PMA), cytochrome b was located into two membrane fractions, one of which was enriched in plasma membrane and cosedimented with alkaline phosphatase, while the other consisted of a denser material cosedimenting with markers of the specific and azurophil granules, i.e. the vitamin-B12-binding protein and myeloperoxidase respectively.	Tetradecanoylphorbol Acetate	39-64	cytochrome b	Bos taurus	72-84
8804315-7	1996	In parallel with these findings, we directly show that whn functions as a transcription factor that can specifically suppress expression of differentiation/TPA-responsive genes.	Tetradecanoylphorbol Acetate	156-159	forkhead box N1	Mus musculus	55-58
9138088-7	1997	Conversely, the DNA-binding of the transcription factor AP-2 was slightly reduced by TPA-induced HL-60 differentiation but unchanged during granulocyte differentiation.	Tetradecanoylphorbol Acetate	85-88	transcription factor AP-2 alpha	Homo sapiens	56-60
9177393-8	1997	Addition of TSH (0.1-0.5 mU/mL), however, to either TPA or EGF dose dependently inhibited the c-jun and c-fos mRNA elicited by these agents.	Tetradecanoylphorbol Acetate	52-55	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	94-99
9177393-8	1997	Addition of TSH (0.1-0.5 mU/mL), however, to either TPA or EGF dose dependently inhibited the c-jun and c-fos mRNA elicited by these agents.	Tetradecanoylphorbol Acetate	52-55	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-109
8909987-0	1996	GTP-binding protein regulates the contractile response elicited by the phorbol ester (PMA)-induced activation of protein kinase C in the isolated rat aorta.	Tetradecanoylphorbol Acetate	86-89	RAS like proto-oncogene B	Rattus norvegicus	0-19
4054128-4	1985	In resting PMN and in PMN activated by phorbol myristate acetate (PMA), cytochrome b was located into two membrane fractions, one of which was enriched in plasma membrane and cosedimented with alkaline phosphatase, while the other consisted of a denser material cosedimenting with markers of the specific and azurophil granules, i.e. the vitamin-B12-binding protein and myeloperoxidase respectively.	Tetradecanoylphorbol Acetate	66-69	cytochrome b	Bos taurus	72-84
9154841-3	1997	In rat fibroblasts overexpressing the c-Src proto-oncogene, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced anchorage-independent growth and other transformation-related phenotypes.	Tetradecanoylphorbol Acetate	78-114	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	38-43
4053280-4	1985	We have developed an assay system which effectively measured tumor promoter (TPA)-induced ornithine decarboxylase activity on 3-4 mm skin samples from mice and humans.	Tetradecanoylphorbol Acetate	77-80	ornithine decarboxylase, structural 1	Mus musculus	90-113
9154841-3	1997	In rat fibroblasts overexpressing the c-Src proto-oncogene, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced anchorage-independent growth and other transformation-related phenotypes.	Tetradecanoylphorbol Acetate	116-119	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	38-43
9153199-5	1997	Additionally, the rapid stimulatory effect of GnRH-A was blocked by the selective PKC inhibitor GF109203X, by TPA-mediated down-regulation of endogenous PKC, or by Ca2+ removal.	Tetradecanoylphorbol Acetate	110-113	protein kinase C, delta	Mus musculus	153-156
8883899-8	1996	The protein kinase C (PKC) inhibitor, chelerythrine chloride, also reduced excitatory amino acid efflux, wheres the PKC activator phorbol 12-myristate 13-acetate (PMA) enhanced their release.	Tetradecanoylphorbol Acetate	130-161	protein kinase C, gamma	Rattus norvegicus	4-20
3915532-3	1985	The increase in the MEP transcript, which is dependent on the PDGF concentration, begins 3 to 4 h after PDGF addition and is maximal at 12 h. The accumulation of the MEP transcript is growth-factor specific: PDGF and the tumor promoter 12-O-tetradecanoylphorbol-13-acetate, an agent which acts like PDGF, induce MEP RNA accumulation, whereas epidermal growth factor, somatomedin C, insulin, and whole plasma do not.	Tetradecanoylphorbol Acetate	236-272	neurolysin (metallopeptidase M3 family)	Mus musculus	20-23
8883899-8	1996	The protein kinase C (PKC) inhibitor, chelerythrine chloride, also reduced excitatory amino acid efflux, wheres the PKC activator phorbol 12-myristate 13-acetate (PMA) enhanced their release.	Tetradecanoylphorbol Acetate	130-161	protein kinase C, gamma	Rattus norvegicus	22-25
8883899-8	1996	The protein kinase C (PKC) inhibitor, chelerythrine chloride, also reduced excitatory amino acid efflux, wheres the PKC activator phorbol 12-myristate 13-acetate (PMA) enhanced their release.	Tetradecanoylphorbol Acetate	130-161	protein kinase C, gamma	Rattus norvegicus	116-119
8883899-8	1996	The protein kinase C (PKC) inhibitor, chelerythrine chloride, also reduced excitatory amino acid efflux, wheres the PKC activator phorbol 12-myristate 13-acetate (PMA) enhanced their release.	Tetradecanoylphorbol Acetate	163-166	protein kinase C, gamma	Rattus norvegicus	4-20
8883899-8	1996	The protein kinase C (PKC) inhibitor, chelerythrine chloride, also reduced excitatory amino acid efflux, wheres the PKC activator phorbol 12-myristate 13-acetate (PMA) enhanced their release.	Tetradecanoylphorbol Acetate	163-166	protein kinase C, gamma	Rattus norvegicus	22-25
8883899-8	1996	The protein kinase C (PKC) inhibitor, chelerythrine chloride, also reduced excitatory amino acid efflux, wheres the PKC activator phorbol 12-myristate 13-acetate (PMA) enhanced their release.	Tetradecanoylphorbol Acetate	163-166	protein kinase C, gamma	Rattus norvegicus	116-119
9153199-7	1997	The rapid effect of GnRH-A upon PKCdelta mRNA levels in serum-starved cells was mimicked by TPA, but not by ionomycin, and was abolished by down-regulation of PKC or by Ca2+ removal.	Tetradecanoylphorbol Acetate	92-95	protein kinase C, delta	Mus musculus	32-40
9153199-7	1997	The rapid effect of GnRH-A upon PKCdelta mRNA levels in serum-starved cells was mimicked by TPA, but not by ionomycin, and was abolished by down-regulation of PKC or by Ca2+ removal.	Tetradecanoylphorbol Acetate	92-95	protein kinase C, delta	Mus musculus	32-35
9153199-9	1997	Western blot analysis revealed that GnRH-A and TPA stimulated (within 5 min) the activation and some degradation of PKCdelta and PKCepsilon.	Tetradecanoylphorbol Acetate	47-50	protein kinase C, delta	Mus musculus	116-124
9164852-4	1997	Treatment of cells with 500 nM PMA for 3 h led to the complete depletion of PKC-delta and the partial depletion of PKC-alpha but did not significantly affect the expression of the other PKC isoforms.	Tetradecanoylphorbol Acetate	31-34	protein kinase C, delta	Mus musculus	76-85
9115222-3	1997	Here we demonstrate that PAF or phorbol 12-myristate 13-acetate (PMA) pretreatment inhibited wild type PAFR-induced PLC-mediated responses by approximately 90%, whereas these responses to the phosphorylation-deficient mPAFR were inhibited by approximately 50%, despite normal G protein coupling, suggesting a distal inhibitory locus.	Tetradecanoylphorbol Acetate	32-63	platelet-activating factor receptor	Mus musculus	218-223
9115222-3	1997	Here we demonstrate that PAF or phorbol 12-myristate 13-acetate (PMA) pretreatment inhibited wild type PAFR-induced PLC-mediated responses by approximately 90%, whereas these responses to the phosphorylation-deficient mPAFR were inhibited by approximately 50%, despite normal G protein coupling, suggesting a distal inhibitory locus.	Tetradecanoylphorbol Acetate	65-68	platelet-activating factor receptor	Mus musculus	218-223
3915532-3	1985	The increase in the MEP transcript, which is dependent on the PDGF concentration, begins 3 to 4 h after PDGF addition and is maximal at 12 h. The accumulation of the MEP transcript is growth-factor specific: PDGF and the tumor promoter 12-O-tetradecanoylphorbol-13-acetate, an agent which acts like PDGF, induce MEP RNA accumulation, whereas epidermal growth factor, somatomedin C, insulin, and whole plasma do not.	Tetradecanoylphorbol Acetate	236-272	neurolysin (metallopeptidase M3 family)	Mus musculus	166-169
9351190-3	1997	Additionally, in these cells which are usually devoid of significant amounts of cytoplasmic intermediate filament (cIF) proteins, synthesis and accumulation of the cIF protein vimentin was rapidly induced by TPA treatment and almost all cells became vimentin-positive.	Tetradecanoylphorbol Acetate	208-211	vimentin	Mus musculus	176-184
9351190-3	1997	Additionally, in these cells which are usually devoid of significant amounts of cytoplasmic intermediate filament (cIF) proteins, synthesis and accumulation of the cIF protein vimentin was rapidly induced by TPA treatment and almost all cells became vimentin-positive.	Tetradecanoylphorbol Acetate	208-211	vimentin	Mus musculus	250-258
3915532-3	1985	The increase in the MEP transcript, which is dependent on the PDGF concentration, begins 3 to 4 h after PDGF addition and is maximal at 12 h. The accumulation of the MEP transcript is growth-factor specific: PDGF and the tumor promoter 12-O-tetradecanoylphorbol-13-acetate, an agent which acts like PDGF, induce MEP RNA accumulation, whereas epidermal growth factor, somatomedin C, insulin, and whole plasma do not.	Tetradecanoylphorbol Acetate	236-272	neurolysin (metallopeptidase M3 family)	Mus musculus	166-169
9351190-6	1997	We suggest that in MPC-11 cells undergoing apoptosis in response to TPA treatment vimentin as well as lamin B are degraded, leading to a rearrangement and eventual loss of their respective filament networks.	Tetradecanoylphorbol Acetate	68-71	vimentin	Mus musculus	82-90
8687498-6	1996	Phorbol-12-myristate-13-acetate (PMA) pretreatment of the hepatocytes clearly inhibited the glycogenolytic potency of Ap3A and ADP, but had only a minor effect on the potency of Ap4A or ATP.	Tetradecanoylphorbol Acetate	0-31	seminal vesicle secretory protein 4	Rattus norvegicus	118-130
2995448-8	1985	beta-Glucuronidase levels in the BAL fluids increased from 0.85 U/ml to 4.36 U/ml and 8.25 U/ml in FNLP- and PMA-treated animals, respectively.	Tetradecanoylphorbol Acetate	109-112	beta-glucuronidase	Macaca mulatta	0-18
8687498-6	1996	Phorbol-12-myristate-13-acetate (PMA) pretreatment of the hepatocytes clearly inhibited the glycogenolytic potency of Ap3A and ADP, but had only a minor effect on the potency of Ap4A or ATP.	Tetradecanoylphorbol Acetate	33-36	seminal vesicle secretory protein 4	Rattus norvegicus	118-130
8702464-5	1996	Our approach was to mutate either the first, the second, or both zinc fingers of PKCdelta, to express the mutated enzyme in NIH 3T3 cells, and to monitor the effect of the mutations on the dose-response curve for translocation induced by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	238-269	protein kinase C, delta	Mus musculus	81-89
8702464-8	1996	We conclude that the zinc fingers in the intact PKC are not equivalent and that the second zinc finger plays the predominant role in translocation of protein kinase Cdelta in response to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	187-218	protein kinase C, delta	Mus musculus	48-51
9180294-3	1997	Although the expression of BCL-6 transcripts was very low or undetectable in untreated HL-60 or U-937 cells, treatment of these cells with TPA to induce monocytic differentiation resulted in an apparent increase of BCL-6 mRNA, suggesting that BCL-6 gene expression is not limited to B cells and it is closely associated with monocytic lineage differentiation.	Tetradecanoylphorbol Acetate	139-142	BCL6 transcription repressor	Homo sapiens	27-32
9180294-3	1997	Although the expression of BCL-6 transcripts was very low or undetectable in untreated HL-60 or U-937 cells, treatment of these cells with TPA to induce monocytic differentiation resulted in an apparent increase of BCL-6 mRNA, suggesting that BCL-6 gene expression is not limited to B cells and it is closely associated with monocytic lineage differentiation.	Tetradecanoylphorbol Acetate	139-142	BCL6 transcription repressor	Homo sapiens	215-220
9180294-3	1997	Although the expression of BCL-6 transcripts was very low or undetectable in untreated HL-60 or U-937 cells, treatment of these cells with TPA to induce monocytic differentiation resulted in an apparent increase of BCL-6 mRNA, suggesting that BCL-6 gene expression is not limited to B cells and it is closely associated with monocytic lineage differentiation.	Tetradecanoylphorbol Acetate	139-142	BCL6 transcription repressor	Homo sapiens	215-220
9180294-4	1997	The BCL-6 transcripts in TPA-treated U-937 cells were superinduced by the treatment with cycloheximide (CHX) and the half-life of the BCL-6 mRNA was apparently prolonged when TPA-treated U-937 cells were exposed to CHX in the presence of actinomycin D (ACD).	Tetradecanoylphorbol Acetate	25-28	BCL6 transcription repressor	Homo sapiens	4-9
9180294-4	1997	The BCL-6 transcripts in TPA-treated U-937 cells were superinduced by the treatment with cycloheximide (CHX) and the half-life of the BCL-6 mRNA was apparently prolonged when TPA-treated U-937 cells were exposed to CHX in the presence of actinomycin D (ACD).	Tetradecanoylphorbol Acetate	25-28	BCL6 transcription repressor	Homo sapiens	134-139
9180294-4	1997	The BCL-6 transcripts in TPA-treated U-937 cells were superinduced by the treatment with cycloheximide (CHX) and the half-life of the BCL-6 mRNA was apparently prolonged when TPA-treated U-937 cells were exposed to CHX in the presence of actinomycin D (ACD).	Tetradecanoylphorbol Acetate	175-178	BCL6 transcription repressor	Homo sapiens	4-9
9180294-4	1997	The BCL-6 transcripts in TPA-treated U-937 cells were superinduced by the treatment with cycloheximide (CHX) and the half-life of the BCL-6 mRNA was apparently prolonged when TPA-treated U-937 cells were exposed to CHX in the presence of actinomycin D (ACD).	Tetradecanoylphorbol Acetate	175-178	BCL6 transcription repressor	Homo sapiens	134-139
9180294-5	1997	Furthermore, the nuclear run-on assay revealed that the BCL-6 transcription signals were enhanced by TPA treatment.	Tetradecanoylphorbol Acetate	101-104	BCL6 transcription repressor	Homo sapiens	56-61
9180294-6	1997	These results suggest that the increase of BCL-6 mRNA in U-937 cells stimulated with TPA to induce monocytic lineage differentiation is mediated by both transcriptional and post-transcriptional regulation.	Tetradecanoylphorbol Acetate	85-88	BCL6 transcription repressor	Homo sapiens	43-48
8922537-1	1996	Insulin and 12-O-tetradecanoyl phorbol-13-acetate (TPA) induce both glucose uptake and translocation of protein kinase C (PKC) from cytosol to membrane in insulin-sensitive tissues as previously reported by several investigators.	Tetradecanoylphorbol Acetate	12-49	protein kinase C, alpha	Rattus norvegicus	122-125
2991376-2	1985	Macrophages incubated for 48 hr or more with concentrated L cell-conditioned medium as a source of M-CSF released two to three times as much O2- in response to PMA as did unexposed macrophages.	Tetradecanoylphorbol Acetate	160-163	colony stimulating factor 1 (macrophage)	Mus musculus	99-104
9155018-6	1997	Further, MNK1 was activated upon stimulation of HeLa cells with 12-O-tetradecanoylphorbol-13-acetate, fetal calf serum, anisomycin, UV irradiation, tumor necrosis factor-alpha, interleukin-1beta, or osmotic shock, and the activation by these stimuli was differentially inhibited by the MEK inhibitor PD098059 or the p38 MAP kinase inhibitor SB202190.	Tetradecanoylphorbol Acetate	64-100	MAPK interacting serine/threonine kinase 1	Homo sapiens	9-13
2992509-3	1985	O-2 production induced by each of phorbol myristate acetate, concanavalin A, and A23187, however, was rather resistant to the pretreatment with IAP.	Tetradecanoylphorbol Acetate	34-59	immunoglobulin kappa variable 1D-39	Homo sapiens	0-3
9142914-5	1997	Gastrin stimulation increased c-fos and c-jun mRNA abundance and AP-1-dependent transcriptional activity, as assessed by a reporter construct in which the CAT reporter gene is under the control of a 12-O-tetradecanoylphorbol-13-acetate response element multimer.	Tetradecanoylphorbol Acetate	199-235	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-35
9142914-5	1997	Gastrin stimulation increased c-fos and c-jun mRNA abundance and AP-1-dependent transcriptional activity, as assessed by a reporter construct in which the CAT reporter gene is under the control of a 12-O-tetradecanoylphorbol-13-acetate response element multimer.	Tetradecanoylphorbol Acetate	199-235	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	40-45
9142914-5	1997	Gastrin stimulation increased c-fos and c-jun mRNA abundance and AP-1-dependent transcriptional activity, as assessed by a reporter construct in which the CAT reporter gene is under the control of a 12-O-tetradecanoylphorbol-13-acetate response element multimer.	Tetradecanoylphorbol Acetate	199-235	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-69
8922537-1	1996	Insulin and 12-O-tetradecanoyl phorbol-13-acetate (TPA) induce both glucose uptake and translocation of protein kinase C (PKC) from cytosol to membrane in insulin-sensitive tissues as previously reported by several investigators.	Tetradecanoylphorbol Acetate	51-54	protein kinase C, alpha	Rattus norvegicus	122-125
8922537-5	1996	TPA also induced time-dependent increases in PKC alpha and gamma (34% and 500% increase, respectively) but not in PKC zeta.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	45-54
8922537-6	1996	However, PKC beta I mRNA was decreased for up to 60 min and then maintained at under the basal level during stimulation with insulin and TPA.	Tetradecanoylphorbol Acetate	137-140	protein kinase C, beta	Rattus norvegicus	9-17
8871061-4	1996	Subsequent analysis of the human ICAM-1 promoter has revealed that both 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumour necrosis factor-alpha (TNF-alpha) upregulate ICAM-1 expression through the presence of a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC).	Tetradecanoylphorbol Acetate	72-108	intercellular adhesion molecule 1	Homo sapiens	33-39
8871061-4	1996	Subsequent analysis of the human ICAM-1 promoter has revealed that both 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumour necrosis factor-alpha (TNF-alpha) upregulate ICAM-1 expression through the presence of a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC).	Tetradecanoylphorbol Acetate	72-108	intercellular adhesion molecule 1	Homo sapiens	171-177
9202672-5	1997	Cells (three dishes per group) were treated with the PK-C activating phorbol ester phorbol-12-myristate-13-acetate (PMA) (100 nM) or vehicle for 1 hr and challenged with EGF (50 ng/ml) or vehicle for 15 min.	Tetradecanoylphorbol Acetate	83-114	protein kinase C, gamma	Rattus norvegicus	53-57
9202672-5	1997	Cells (three dishes per group) were treated with the PK-C activating phorbol ester phorbol-12-myristate-13-acetate (PMA) (100 nM) or vehicle for 1 hr and challenged with EGF (50 ng/ml) or vehicle for 15 min.	Tetradecanoylphorbol Acetate	116-119	protein kinase C, gamma	Rattus norvegicus	53-57
8871061-4	1996	Subsequent analysis of the human ICAM-1 promoter has revealed that both 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumour necrosis factor-alpha (TNF-alpha) upregulate ICAM-1 expression through the presence of a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC).	Tetradecanoylphorbol Acetate	110-113	intercellular adhesion molecule 1	Homo sapiens	33-39
2991234-1	1985	The phosphorylation of the membrane skeleton components protein 4.1 and protein 4.9 in intact erythrocytes is shown to increase in the presence of either 1 microM 12-O-tetradecanoyl phorbol 13-acetate or 2 mM dibutyryl cAMP.	Tetradecanoylphorbol Acetate	163-200	erythrocyte membrane protein band 4.1	Homo sapiens	56-67
8871061-4	1996	Subsequent analysis of the human ICAM-1 promoter has revealed that both 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumour necrosis factor-alpha (TNF-alpha) upregulate ICAM-1 expression through the presence of a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC).	Tetradecanoylphorbol Acetate	110-113	intercellular adhesion molecule 1	Homo sapiens	171-177
8872491-1	1996	We have previously shown that interferon-gamma (IFN-gamma) increases intracellular levels of the lysosomal proteinase, CB, in THP-1 cell primed with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	149-180	cathepsin B	Homo sapiens	119-121
9124569-8	1997	Consistent with this, CCK receptor phosphorylation induced by 12-O-tetradecanoylphorbol-13-acetate treatment did not stimulate receptor internalization.	Tetradecanoylphorbol Acetate	62-98	cholecystokinin	Rattus norvegicus	22-25
8872491-1	1996	We have previously shown that interferon-gamma (IFN-gamma) increases intracellular levels of the lysosomal proteinase, CB, in THP-1 cell primed with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	182-185	cathepsin B	Homo sapiens	119-121
2861859-1	1985	The mechanisms by which topically applied retinoic acid to mouse skin inhibits tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced epidermal ornithine decarboxylase activity were analyzed.	Tetradecanoylphorbol Acetate	94-130	ornithine decarboxylase, structural 1	Mus musculus	155-178
8768691-7	1996	In addition, treatment of the astrocytes with phorbol myristate acetate, a protein kinase C activator, caused a robust increase in CRF-BP levels in the medium.	Tetradecanoylphorbol Acetate	46-71	corticotropin releasing hormone binding protein	Rattus norvegicus	131-137
9067561-5	1997	Myeloperoxidase (MPO) measurements indicated dramatic infiltrations of the skins of all three murine strains by neutrophils within 48 h of a single TPA application.	Tetradecanoylphorbol Acetate	148-151	myeloperoxidase	Mus musculus	0-15
9067561-6	1997	MPO activities remained significantly elevated in the skins of 129/SvEv mice and C57BL/6 mice following eight TPA treatments.	Tetradecanoylphorbol Acetate	110-113	myeloperoxidase	Mus musculus	0-3
9060454-9	1997	Addition of intact specific granule membranes to the plasma membranes from PMA-treated neutrophils markedly decreased phosphorylation in both CD11b and CD18 subunits.	Tetradecanoylphorbol Acetate	75-78	integrin subunit alpha M	Homo sapiens	142-147
9122616-6	1997	When IL-10 and IFN-gamma were added simultaneously to neutrophil culture, IL-10 dose-dependently reduced IFN-gamma-induced increase of CR3 expression, O(2)- production (in response to both FMLP and phorbol 12-myristate 13-acetate, or PMA) and ADCC, but did not change Fc gamma RI expression on phagocytes.	Tetradecanoylphorbol Acetate	198-229	interleukin 10	Homo sapiens	5-10
9122616-6	1997	When IL-10 and IFN-gamma were added simultaneously to neutrophil culture, IL-10 dose-dependently reduced IFN-gamma-induced increase of CR3 expression, O(2)- production (in response to both FMLP and phorbol 12-myristate 13-acetate, or PMA) and ADCC, but did not change Fc gamma RI expression on phagocytes.	Tetradecanoylphorbol Acetate	198-229	interleukin 10	Homo sapiens	74-79
8703996-1	1996	The effect of phorbol 12-myristate 13-acetate (PMA) on the expression and shedding of intercellular adhesion molecule-1 (ICAM-1) was investigated on the hematopoietic cell lines K 562 and U 937 using flow cytometry, fluorescence microscopy and ELISA technique.	Tetradecanoylphorbol Acetate	14-45	intercellular adhesion molecule 1	Homo sapiens	121-127
8703996-1	1996	The effect of phorbol 12-myristate 13-acetate (PMA) on the expression and shedding of intercellular adhesion molecule-1 (ICAM-1) was investigated on the hematopoietic cell lines K 562 and U 937 using flow cytometry, fluorescence microscopy and ELISA technique.	Tetradecanoylphorbol Acetate	47-50	intercellular adhesion molecule 1	Homo sapiens	86-119
2861859-1	1985	The mechanisms by which topically applied retinoic acid to mouse skin inhibits tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced epidermal ornithine decarboxylase activity were analyzed.	Tetradecanoylphorbol Acetate	132-135	ornithine decarboxylase, structural 1	Mus musculus	155-178
2861859-3	1985	In addition, inhibition of TPA-caused increased ornithine decarboxylase activity does not appear to be due to enhanced degradation and/or post-translational modification of ornithine decarboxylase by transglutaminase-mediated putrescine incorporation.	Tetradecanoylphorbol Acetate	27-30	ornithine decarboxylase, structural 1	Mus musculus	48-71
9124366-5	1997	12-O-tetradecanoylphorbol-13-acetate stimulated surfactant secretion and activated PKC-alpha, -beta, -delta, and -eta isozymes in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-36	protein kinase C, alpha	Rattus norvegicus	83-117
8703996-1	1996	The effect of phorbol 12-myristate 13-acetate (PMA) on the expression and shedding of intercellular adhesion molecule-1 (ICAM-1) was investigated on the hematopoietic cell lines K 562 and U 937 using flow cytometry, fluorescence microscopy and ELISA technique.	Tetradecanoylphorbol Acetate	47-50	intercellular adhesion molecule 1	Homo sapiens	121-127
2861859-4	1985	We found that retinoic acid inhibits the synthesis of ornithine decarboxylase caused by TPA.	Tetradecanoylphorbol Acetate	88-91	ornithine decarboxylase, structural 1	Mus musculus	54-77
8703996-2	1996	At low concentration of 1 nM, PMA stimulated the expression of ICAM-1 on the cell surface about 4-fold within 24 h, whereas a short-term treatment with 100 nM PMA led to the shedding of 35% of ICAM-1 from the surface of K 562 cells.	Tetradecanoylphorbol Acetate	30-33	intercellular adhesion molecule 1	Homo sapiens	63-69
9012737-10	1997	The fatty acids also inhibited the expression of ICAM-1 and E-selectin induced by phorbol 12-myristate 13-acetate, showing that inhibition occurred at a post-TNF-alpha receptor binding level.	Tetradecanoylphorbol Acetate	82-113	intercellular adhesion molecule 1	Homo sapiens	49-55
8703996-2	1996	At low concentration of 1 nM, PMA stimulated the expression of ICAM-1 on the cell surface about 4-fold within 24 h, whereas a short-term treatment with 100 nM PMA led to the shedding of 35% of ICAM-1 from the surface of K 562 cells.	Tetradecanoylphorbol Acetate	159-162	intercellular adhesion molecule 1	Homo sapiens	63-69
2861859-5	1985	Application of 10 nmol TPA to mouse skin led to a dramatic induction of epidermal ornithine decarboxylase activity which was paralled by increased [3H]difluoromethylornithine binding and an increased incorporation of [35S]methionine into the enzyme.	Tetradecanoylphorbol Acetate	23-26	ornithine decarboxylase, structural 1	Mus musculus	82-105
8703996-2	1996	At low concentration of 1 nM, PMA stimulated the expression of ICAM-1 on the cell surface about 4-fold within 24 h, whereas a short-term treatment with 100 nM PMA led to the shedding of 35% of ICAM-1 from the surface of K 562 cells.	Tetradecanoylphorbol Acetate	159-162	intercellular adhesion molecule 1	Homo sapiens	193-199
2861859-6	1985	Application of 17 nmol retinoic acid 1 h prior to application of 10 nmol TPA to skin resulted in inhibition of the induction of activity which accompanied inhibition of [3H]difluoromethylornithine binding and [35S]methionine incorporation into ornithine decarboxylase protein as determined by the tube-gel electrophoresis of the enzyme immunoprecipitated with monoclonal antibodies to it.	Tetradecanoylphorbol Acetate	73-76	ornithine decarboxylase, structural 1	Mus musculus	244-267
9003008-9	1997	Moreover, the phorbol ester phorbol 12-myristate 13-acetate mimicked most of the effects of AngII in BAC and decreased both AT2-binding sites and mRNA on PC12W cells, indicating that the hormonal regulation of both AT1 and AT2 receptors is mediated through protein kinase C activation.	Tetradecanoylphorbol Acetate	28-59	serine (or cysteine) peptidase inhibitor, clade B, member 9d	Mus musculus	124-127
2861859-8	1985	The results indicate that retinoic acid possibly inhibits TPA-caused synthesis of ornithine decarboxylase protein selectively.	Tetradecanoylphorbol Acetate	58-61	ornithine decarboxylase, structural 1	Mus musculus	82-105
8694833-2	1996	By contrast, 1, 25 D3 increases the expression of CD11b, an early myeloid marker and enhances adherence to plastic following priming of the cells with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	184-187	integrin subunit alpha M	Homo sapiens	50-55
3859699-8	1985	Thus human skin, like mouse skin, is responsive to TPA for ODC induction.	Tetradecanoylphorbol Acetate	51-54	ornithine decarboxylase, structural 1	Mus musculus	59-62
17180098-4	1996	Stimulation of T cells by treatment with PMA and ionomycine (P/I) lead up to a 100-fold maximal increase in CD95-L mRNA after 4 h. CD95-L mRNA is produced by activated CD8 and CD4T cells.	Tetradecanoylphorbol Acetate	41-44	CD8a molecule	Homo sapiens	168-171
9179619-2	1997	We found that adding increasing amounts of tPA significantly (r = 0.89, P &lt; 0.025) and progressively reduced O2.- generation by neutrophils treated with phorbol myristate acetate (PMA) in vitro.	Tetradecanoylphorbol Acetate	156-181	chromosome 20 open reading frame 181	Homo sapiens	43-46
9179619-2	1997	We found that adding increasing amounts of tPA significantly (r = 0.89, P &lt; 0.025) and progressively reduced O2.- generation by neutrophils treated with phorbol myristate acetate (PMA) in vitro.	Tetradecanoylphorbol Acetate	183-186	chromosome 20 open reading frame 181	Homo sapiens	43-46
3159569-8	1985	We observed strong induction of c-fos and to a lesser extent of c-myc also by TPA, and by the calcium ionophore A23187, indicating an important role for kinase C in proto-oncogene activation by growth factors.	Tetradecanoylphorbol Acetate	78-81	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	32-37
9039645-6	1997	The PKC activator phorbol myristate acetate (PMA) also increased IR current density, whereas the inactive alpha-4 isoform was ineffective.	Tetradecanoylphorbol Acetate	18-43	protein kinase C, gamma	Rattus norvegicus	4-7
9039645-6	1997	The PKC activator phorbol myristate acetate (PMA) also increased IR current density, whereas the inactive alpha-4 isoform was ineffective.	Tetradecanoylphorbol Acetate	45-48	protein kinase C, gamma	Rattus norvegicus	4-7
8836876-9	1996	The [3H]alkylacyl-GP and [3H]alkylacyl-GPethanol, phospholipase D breakdown products from [3H]alkylacyl-GPC, obtained after neutrophil prelabelling and activation by phorbol myristate acetate, were exclusively present in the plasma membranes.	Tetradecanoylphorbol Acetate	166-191	glycophorin C (Gerbich blood group)	Homo sapiens	104-107
8836877-6	1996	12-O-Tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC)-activating phorbol ester, inhibited the arsenite-induced accumulation of hsp27.	Tetradecanoylphorbol Acetate	0-36	heat shock protein 1	Mus musculus	142-147
8836877-6	1996	12-O-Tetradecanoylphorbol-13-acetate (TPA), a protein kinase C (PKC)-activating phorbol ester, inhibited the arsenite-induced accumulation of hsp27.	Tetradecanoylphorbol Acetate	38-41	heat shock protein 1	Mus musculus	142-147
9015316-14	1997	Increased levels of alpha2 and MMP-1 mRNA in collagen gel-stimulated fibroblasts were abrogated by bisindolylmaleimide GF 109203X and calphostin C, chemical inhibitors for PKC, but retained when cells were depleted of 12-myristate 13-acetate (PMA)-inducible PKC isoforms by 24 h of pretreatment with phorbol PMA.	Tetradecanoylphorbol Acetate	243-246	protein kinase C zeta	Homo sapiens	172-175
3871817-1	1985	We have examined the effect of tumor-promoting phorbol esters such as phorbol myristate acetate (PMA) on the murine B cell leukemia BCL-1 and its in vitro adapted derivative CW.13.20.	Tetradecanoylphorbol Acetate	70-95	cyclin D1	Mus musculus	132-137
8999881-4	1997	In contrast, 12-O-tetradecanoylphorbol-13-acetate strongly activated p90(RSK) but only weakly stimulated p70(S6K).	Tetradecanoylphorbol Acetate	13-49	annexin A6	Homo sapiens	105-108
9002947-3	1997	Cortactin, but not its related protein HS1, is upregulated during the phorbol 12-myristate 13-acetate (PMA)-mediated maturation of a human megakaryoblastic cell line CMK.	Tetradecanoylphorbol Acetate	70-101	cortactin	Homo sapiens	0-9
9002947-3	1997	Cortactin, but not its related protein HS1, is upregulated during the phorbol 12-myristate 13-acetate (PMA)-mediated maturation of a human megakaryoblastic cell line CMK.	Tetradecanoylphorbol Acetate	70-101	cytidine/uridine monophosphate kinase 1	Homo sapiens	166-169
9002947-3	1997	Cortactin, but not its related protein HS1, is upregulated during the phorbol 12-myristate 13-acetate (PMA)-mediated maturation of a human megakaryoblastic cell line CMK.	Tetradecanoylphorbol Acetate	103-106	cortactin	Homo sapiens	0-9
3871817-1	1985	We have examined the effect of tumor-promoting phorbol esters such as phorbol myristate acetate (PMA) on the murine B cell leukemia BCL-1 and its in vitro adapted derivative CW.13.20.	Tetradecanoylphorbol Acetate	97-100	cyclin D1	Mus musculus	132-137
8663173-3	1996	Activation of PKC by 12-0-tetradecanoylphorbol-13-acetate (TPA) did not affect the basal amount of p21(ras).GTP but significantly reduced insulin-induced increases in p21(ras).GTP.	Tetradecanoylphorbol Acetate	59-62	KRAS proto-oncogene, GTPase	Rattus norvegicus	167-170
9022759-1	1997	Human megakaryoblastic cells (CMK line) are known to differentiate to mature megakaryocyte-like cells by treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	120-156	cytidine/uridine monophosphate kinase 1	Homo sapiens	30-33
3871817-2	1985	Phorbol esters, including PMA and phorbol dibutyrate (PDBu), were potent inhibitors of BCL-1 IgM secretion induced by either LPS or lymphokines; half-maximal inhibition was obtained with 0.1 nM PMA and 0.8 nm PDBu.	Tetradecanoylphorbol Acetate	26-29	cyclin D1	Mus musculus	87-92
9022759-1	1997	Human megakaryoblastic cells (CMK line) are known to differentiate to mature megakaryocyte-like cells by treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	158-161	cytidine/uridine monophosphate kinase 1	Homo sapiens	30-33
8663173-5	1996	Depletion of PKC by an 18-h incubation with TPA or inhibition by bisindolylmaleimide resulted in profound inhibition of the insulin-induced p21(ras).GTP loading.	Tetradecanoylphorbol Acetate	44-47	KRAS proto-oncogene, GTPase	Rattus norvegicus	140-143
3871817-2	1985	Phorbol esters, including PMA and phorbol dibutyrate (PDBu), were potent inhibitors of BCL-1 IgM secretion induced by either LPS or lymphokines; half-maximal inhibition was obtained with 0.1 nM PMA and 0.8 nm PDBu.	Tetradecanoylphorbol Acetate	194-197	cyclin D1	Mus musculus	87-92
2983900-1	1985	Both dehydroepiandrosterone (DHEA) and the synthetic steroid 16 alpha-Br-epiandrosterone (Br-Epi), a more potent inhibitor of glucose-6-phosphate dehydrogenase (G6PDH) than DHEA, inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of superoxide anion (O2-) formation by human neutrophils.	Tetradecanoylphorbol Acetate	191-227	glucose-6-phosphate dehydrogenase	Homo sapiens	126-159
8670165-12	1996	Activation of protein kinase C (PKC) by 1 microgram/ml phorbol 12-myristate 13-acetate (PMA) caused an increase in mucin secretion (342% versus control 100%), comparable with the effect of 40 mM TUDC.	Tetradecanoylphorbol Acetate	55-86	mucin	Canis lupus familiaris	115-120
8670165-12	1996	Activation of protein kinase C (PKC) by 1 microgram/ml phorbol 12-myristate 13-acetate (PMA) caused an increase in mucin secretion (342% versus control 100%), comparable with the effect of 40 mM TUDC.	Tetradecanoylphorbol Acetate	88-91	mucin	Canis lupus familiaris	115-120
9008610-2	1997	METHODS: The expression of CD11b and L-selectin during neutrophil activation with tumor necrosis factor alpha (TNF alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), FMLP, phorbol myristate acetate (PMA), and calcium ionophore A23187 was assessed by flow cytometry.	Tetradecanoylphorbol Acetate	188-213	integrin subunit alpha M	Homo sapiens	27-32
9008610-2	1997	METHODS: The expression of CD11b and L-selectin during neutrophil activation with tumor necrosis factor alpha (TNF alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), FMLP, phorbol myristate acetate (PMA), and calcium ionophore A23187 was assessed by flow cytometry.	Tetradecanoylphorbol Acetate	215-218	integrin subunit alpha M	Homo sapiens	27-32
2983900-1	1985	Both dehydroepiandrosterone (DHEA) and the synthetic steroid 16 alpha-Br-epiandrosterone (Br-Epi), a more potent inhibitor of glucose-6-phosphate dehydrogenase (G6PDH) than DHEA, inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of superoxide anion (O2-) formation by human neutrophils.	Tetradecanoylphorbol Acetate	229-232	glucose-6-phosphate dehydrogenase	Homo sapiens	126-159
9546811-5	1997	With the exception of one clone in the IL-2 group, all clones produced IL-10 on stimulation with anti-CD3 and phorbol-12-myristate 13-acetate (PMA) with similar mean values for both groups.	Tetradecanoylphorbol Acetate	110-141	interleukin 10	Homo sapiens	71-76
3156383-0	1985	Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice.	Tetradecanoylphorbol Acetate	126-151	prolactin	Mus musculus	0-9
9413940-4	1997	Pretreatment of HL-60 cells with Ro 31-8220 also inhibited PMA-induced activation of c-raf-1, a known PKC alpha target.	Tetradecanoylphorbol Acetate	59-62	TNF receptor associated factor 3	Homo sapiens	85-92
8811426-2	1996	Incubation of slices with 1-aminocyclopentane-1,3-trans-dicarboxylic acid (trans-ACPD) or phorbol myristate acetate (PMA) in the presence of okadaic acid (OA) shifted the calcium sensitivity of neuronal NOS in the homogenate or in the cytosolic fraction.	Tetradecanoylphorbol Acetate	90-115	nitric oxide synthase 1	Rattus norvegicus	194-206
8632171-4	1996	Nevertheless, concomitant with an increase in the number of responsive cells, a profound priming of the phorbol 12-myristate 13-acetate-evoked production of superoxide anion was observed in A beta (1-40)-treated cultures.	Tetradecanoylphorbol Acetate	104-135	amyloid beta precursor protein	Rattus norvegicus	190-196
3156383-0	1985	Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice.	Tetradecanoylphorbol Acetate	126-151	ornithine decarboxylase, structural 1	Mus musculus	25-48
3156383-0	1985	Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice.	Tetradecanoylphorbol Acetate	126-151	ornithine decarboxylase, structural 1	Mus musculus	200-223
8752662-7	1996	12-O-Tetradecanoylphorbol 13-acetate increases the size of the chondroitin sulfate chain(s) attached to CD44 but not the proportion of CD44 molecules that carry chondroitin sulfate.	Tetradecanoylphorbol Acetate	0-36	CD44 molecule (Indian blood group)	Homo sapiens	104-108
9034963-9	1997	Down-regulation of PKC by chronic exposure to TPA eliminated stimulation of PLD by TPA but not by STS.	Tetradecanoylphorbol Acetate	46-49	protein kinase C, gamma	Rattus norvegicus	19-22
9034963-9	1997	Down-regulation of PKC by chronic exposure to TPA eliminated stimulation of PLD by TPA but not by STS.	Tetradecanoylphorbol Acetate	83-86	protein kinase C, gamma	Rattus norvegicus	19-22
3156383-0	1985	Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice.	Tetradecanoylphorbol Acetate	126-151	ornithine decarboxylase, structural 1	Mus musculus	225-228
8989665-4	1997	TPA (10 nM) induced a transient 42% decrease in 125I-CNTF binding sites after 4 h of treatment that recovered to near control levels after 7 h of continuous exposure.	Tetradecanoylphorbol Acetate	0-3	ciliary neurotrophic factor	Homo sapiens	53-57
8989665-5	1997	TPA-treated cells showed a decreased sensitivity to CNTF and a sevenfold decrease in levels of STAT3.	Tetradecanoylphorbol Acetate	0-3	ciliary neurotrophic factor	Homo sapiens	52-56
3156383-0	1985	Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice.	Tetradecanoylphorbol Acetate	153-156	prolactin	Mus musculus	0-9
8989665-8	1997	Thus, retinoic acid and TPA regulate CNTF receptors on neuroblastoma cells differently, and the results demonstrate the importance of transcriptional control of CNTF receptors and also implicate translational and post-translational mechanisms in the regulation of cytokine receptors and responses on neurons.	Tetradecanoylphorbol Acetate	24-27	ciliary neurotrophic factor	Homo sapiens	37-41
8836162-13	1996	These latter results were not due to a lack of efficacy because a single administration of DiC8 was as effective as TPA in inducing c-fos mRNA at 30 min.	Tetradecanoylphorbol Acetate	116-119	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-137
3156383-0	1985	Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice.	Tetradecanoylphorbol Acetate	153-156	ornithine decarboxylase, structural 1	Mus musculus	25-48
3156383-0	1985	Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice.	Tetradecanoylphorbol Acetate	153-156	ornithine decarboxylase, structural 1	Mus musculus	200-223
3156383-0	1985	Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice.	Tetradecanoylphorbol Acetate	153-156	ornithine decarboxylase, structural 1	Mus musculus	225-228
9398921-5	1997	Secretion of RANTES-protein in supernatants was investigated after stimulation with 50 ng/ml tumor necrosis factor-alpha (TNF-alpha), interleukin-1-beta (IL-1-beta), lipopolysaccharide (LPS), phorbolmyrisate acetate (PMA), interferon-gamma (IFN-gamma) and serum-free medium (SFM) for 24 hours.	Tetradecanoylphorbol Acetate	217-220	C-C motif chemokine ligand 5	Homo sapiens	13-19
6202789-1	1984	Factors obtained from phorbol myristate acetate (PMA)-stimulated EL-4 thymoma cells, a continuous T cell line, suppressed lymphokine-induced macrophage activation to kill intracellular Leishmania tropica amastigotes.	Tetradecanoylphorbol Acetate	22-47	epilepsy 4	Mus musculus	65-69
8951343-6	1996	However, under these conditions TPA caused almost complete translocation of PKC-alpha from the cytosol to the membrane.	Tetradecanoylphorbol Acetate	32-35	protein kinase C alpha	Bos taurus	76-85
8977262-8	1996	Whereas the phorbolester phorbol myristate acetate was able to downregulate the expression of CD52 on eosinophils in a dose-dependent manner, different eosinophil activating cytokines and chemotaxins had no effect.	Tetradecanoylphorbol Acetate	25-50	CD52 molecule	Homo sapiens	94-98
8650251-6	1996	The accumulation of c-fos; mRNA in the cultured mammary tissues was also increased by human GH, recombinant bovine PRL, cycloheximide, and phorbol 12-myristate 13-acetate (TPA).	Tetradecanoylphorbol Acetate	139-170	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-25
8650251-6	1996	The accumulation of c-fos; mRNA in the cultured mammary tissues was also increased by human GH, recombinant bovine PRL, cycloheximide, and phorbol 12-myristate 13-acetate (TPA).	Tetradecanoylphorbol Acetate	172-175	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-25
8661368-1	1996	The CD4(+) cultures were stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin to activate protein kinase C and increase cytoplasmic free calcium, respectively, in a range of VT concentrations.	Tetradecanoylphorbol Acetate	41-72	CD4 antigen	Mus musculus	4-7
8661368-1	1996	The CD4(+) cultures were stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin to activate protein kinase C and increase cytoplasmic free calcium, respectively, in a range of VT concentrations.	Tetradecanoylphorbol Acetate	74-77	CD4 antigen	Mus musculus	4-7
8661368-12	1996	Taken together, VT enhanced andsolidusor delayed peak IL-2, IL-4, and IL-5 gene expression and secretion in CD4(+) T cells stimulated with PMA and ionomycin.	Tetradecanoylphorbol Acetate	139-142	CD4 antigen	Mus musculus	108-111
6202789-1	1984	Factors obtained from phorbol myristate acetate (PMA)-stimulated EL-4 thymoma cells, a continuous T cell line, suppressed lymphokine-induced macrophage activation to kill intracellular Leishmania tropica amastigotes.	Tetradecanoylphorbol Acetate	49-52	epilepsy 4	Mus musculus	65-69
8955209-1	1996	We have analyzed the induction of the receptor for the anaphylatoxic peptide C3a (C3aR) by the immunomodulator IFN-gamma, the phorbol ester PMA, and dibutyryl cAMP (Bt2cAMP) in comparison with the C5a receptor (C5aR, CD88).	Tetradecanoylphorbol Acetate	140-143	complement C3	Homo sapiens	77-80
6233008-3	1984	(1) When GF-containing fluids from cultures of phorbol myristic acetate (PMA)-activated EL4 thymoma were fractionated by a variety of biochemical techniques.	Tetradecanoylphorbol Acetate	73-76	epilepsy 4	Mus musculus	88-91
9022291-2	1996	The aim of the present study was to evaluate the influence of 12-O-tetradecanoylphorbol 13-acetate (TPA)--a potent ODC inducer on antiproliferative and apoptotic effects of TGF-beta 1 in L1210 leukemic cells.	Tetradecanoylphorbol Acetate	100-103	ornithine decarboxylase, structural 1	Mus musculus	115-118
8635865-7	1996	CPT may indirectly decrease the ornithine decarboxylase-inducing activity of multiple TPA treatments because it can inhibit the stimulation of RNA synthesis by this compound.	Tetradecanoylphorbol Acetate	86-89	ornithine decarboxylase, structural 1	Mus musculus	32-55
8793856-4	1996	Reverse transcription-polymerase chain reaction (RT-PCR) analysis was performed to estimate the c-jun and c-fos mRNA contents in GnRH-, forskolin- (cAMP activator) and tetradecanoyl phorbol acetate- (TPA; protein kinase C activator) treated primary cultures of porcine anterior pituitary cells.	Tetradecanoylphorbol Acetate	200-203	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	96-101
9035611-10	1996	Inhibition of PKC activity by PKC inhibitors (H-7 or staurosporine) or downregulation induced by prolonged treatment with phorbol 12-myristate 13-acetate (PMA) or thyleametoxin (TX) significantly blocked the NE-induced AA release, which indicates PKC is involved in mediating NE-induced AA release.	Tetradecanoylphorbol Acetate	155-158	protein kinase C, alpha	Rattus norvegicus	14-17
8793856-5	1996	Densitometric quantification demonstrated that GnRH and TPA treatment increased c-jun and c-fos mRNA levels significantly, whereas forskolin reduced the levels of both.	Tetradecanoylphorbol Acetate	56-59	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-85
8793856-5	1996	Densitometric quantification demonstrated that GnRH and TPA treatment increased c-jun and c-fos mRNA levels significantly, whereas forskolin reduced the levels of both.	Tetradecanoylphorbol Acetate	56-59	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-95
6423272-3	1984	Application of 1 micrograms 1 alpha, 25(OH)2D3 within 30 min before or after treatment with 10 micrograms TPA caused about 72% inhibition of ODC induction at 4 hr.	Tetradecanoylphorbol Acetate	106-109	ornithine decarboxylase, structural 1	Mus musculus	141-144
8971787-2	1996	Incubation of the cells for 24 h with A beta(25-35) as well as with A beta(1-42) resulted in an enhanced production of reactive oxygen radicals (ROI) in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	165-196	amyloid beta precursor protein	Rattus norvegicus	68-74
8971787-2	1996	Incubation of the cells for 24 h with A beta(25-35) as well as with A beta(1-42) resulted in an enhanced production of reactive oxygen radicals (ROI) in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	198-201	amyloid beta precursor protein	Rattus norvegicus	68-74
6423272-5	1984	The dose required for 50% inhibition was 0.063 micrograms, or 0.15 nmol, which is about one-half that of retinoic acid, a known inhibitor of induction of ODC activity by TPA.	Tetradecanoylphorbol Acetate	170-173	ornithine decarboxylase, structural 1	Mus musculus	154-157
8972916-3	1996	It seemed probable that the absence of AP-1 sites in the promoter of the CHUB2 gene was likely to be responsible for the very dissimilar regulation of the two genes by UV light and TPA, despite the fact that these genes are evolutionarily equivalent.	Tetradecanoylphorbol Acetate	181-184	polyubiquitin-C	Cricetulus griseus	73-78
8647095-9	1996	In HT-1080 cells, CREB-1 was the most prominent t-PACRE-binding activity detected and was greatly increased in cells treated with PMA.	Tetradecanoylphorbol Acetate	130-133	cAMP responsive element binding protein 1	Homo sapiens	18-24
6320872-10	1984	Addition of phorbol myristate acetate to intact neutrophils in the presence of glucose resulted in CO- and cyanide-insensitive respiration, accumulation of O-2, and also in reduction of cytochrome b.	Tetradecanoylphorbol Acetate	12-37	immunoglobulin kappa variable 1D-39	Homo sapiens	156-159
8613475-4	1996	TPA treatment of HT1080 cells induced the expression of interstitial collagenase (MMP-1) and increased the expression of gelatinase B (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), and MT-MMP, a membrane-bound activator of progelatinase A (proMMP-2), while MMP-2 and TIMP-2 expression were decreased.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	135-140
8626571-6	1996	Phosphorylation of Vif was stimulated by phorbol 12-myristate 13-acetate and inhibited by staurosporine and hypericin, a drug with potent anti-HIV activity.	Tetradecanoylphorbol Acetate	41-72	Vif	Human immunodeficiency virus 1	19-22
8945999-3	1996	In contrast, addition of 1 microM phorbol 12-myristate 13-acetate, a stimulator of PKC, led to addition of "new" K+ channel currents in 9 of 20 patches in the basolateral membrane of the CCD, and the mean increase in NP0, a product of channel number (N) and open probability (Pzero), was 0.90 in these 9 patches.	Tetradecanoylphorbol Acetate	34-65	protein kinase C, gamma	Rattus norvegicus	83-86
8946002-5	1996	Consistent with the cotransporter stimulation, PMA decreased steady-state pHi in the presence of CO2/ HCO3-.	Tetradecanoylphorbol Acetate	47-50	glucose-6-phosphate isomerase	Oryctolagus cuniculus	74-77
6320872-10	1984	Addition of phorbol myristate acetate to intact neutrophils in the presence of glucose resulted in CO- and cyanide-insensitive respiration, accumulation of O-2, and also in reduction of cytochrome b.	Tetradecanoylphorbol Acetate	12-37	mitochondrially encoded cytochrome b	Homo sapiens	186-198
6704115-3	1984	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) also inhibited B-16 differentiation and the combination of TPA with IFN-alpha A/D (Bgl) or mouse L-cell interferon was synergistic in delaying melanogenesis.	Tetradecanoylphorbol Acetate	19-55	interferon alpha	Mus musculus	130-139
8903410-8	1996	HGF, phorbol myristate acetate (PMA) and a DG analog, oleylacetylglycerol (OAG), activated the expression of c-jun and c-fos messenger RNAs (mRNAs).	Tetradecanoylphorbol Acetate	5-30	hepatocyte growth factor	Rattus norvegicus	0-3
8903410-8	1996	HGF, phorbol myristate acetate (PMA) and a DG analog, oleylacetylglycerol (OAG), activated the expression of c-jun and c-fos messenger RNAs (mRNAs).	Tetradecanoylphorbol Acetate	5-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	119-124
8903410-8	1996	HGF, phorbol myristate acetate (PMA) and a DG analog, oleylacetylglycerol (OAG), activated the expression of c-jun and c-fos messenger RNAs (mRNAs).	Tetradecanoylphorbol Acetate	32-35	hepatocyte growth factor	Rattus norvegicus	0-3
8903410-8	1996	HGF, phorbol myristate acetate (PMA) and a DG analog, oleylacetylglycerol (OAG), activated the expression of c-jun and c-fos messenger RNAs (mRNAs).	Tetradecanoylphorbol Acetate	32-35	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	119-124
8630024-8	1996	However, flt-1, flt-4 and KDR transcript levels were enhanced following treatment with tetradecanoylphorbol acetate.	Tetradecanoylphorbol Acetate	87-115	fms related receptor tyrosine kinase 4	Homo sapiens	16-21
8630024-8	1996	However, flt-1, flt-4 and KDR transcript levels were enhanced following treatment with tetradecanoylphorbol acetate.	Tetradecanoylphorbol Acetate	87-115	kinase insert domain receptor	Homo sapiens	26-29
8605349-5	1996	IL-15 stimulated the proliferation of freshly isolated leukemic B cells, but not resting normal B lymphocytes, the latter being able to grow in the presence of IL-15 only after in vitro preactivation with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	205-230	interleukin 15	Homo sapiens	0-5
8605349-5	1996	IL-15 stimulated the proliferation of freshly isolated leukemic B cells, but not resting normal B lymphocytes, the latter being able to grow in the presence of IL-15 only after in vitro preactivation with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	205-230	interleukin 15	Homo sapiens	160-165
6320907-0	1984	Phosphorylation of myosin light chain in intact pig leukocytes stimulated by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	77-108	myosin light chain 1	Sus scrofa	19-37
8928811-5	1996	After 8 h of TPA exposure, actin filaments reassembled and vinculin again localized to the cell periphery.	Tetradecanoylphorbol Acetate	13-16	vinculin	Mus musculus	59-67
8928811-8	1996	Both vinculin and talin concentrations increased with prolonged TPA treatment.	Tetradecanoylphorbol Acetate	64-67	vinculin	Mus musculus	5-13
8885992-2	1996	Go 6976 inhibited the Ca(2+)- and diacylglycerol (DAG)-dependent PKC activities in beta-cell extracts in vitro and fully inhibited insulin secretory responses of rat islets of Langerhans to the PKC activator 4 beta phorbol myristate acetate (PMA), suggesting that it was an effective inhibitor of the DAG-dependent isoforms of PKC in situ.	Tetradecanoylphorbol Acetate	242-245	protein kinase C, gamma	Rattus norvegicus	65-68
6320907-2	1984	The labeling of the myosin light chain (Mr = 21000) was increased by exposure of the cells to phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	94-125	myosin light chain 1	Sus scrofa	20-38
6325215-7	1984	The data suggest that TPA induced secretion in pituitary tumour cells may result from the previously reported ability of the phorbol ester to stimulate the activity of phospholipase A2, and to the subsequent biosynthesis of prostaglandins.	Tetradecanoylphorbol Acetate	22-25	phospholipase A2, group IB, pancreas	Mus musculus	168-184
8797597-2	1996	c-Jun and v-Jun bind specifically to 12-O-tetradecanoylphorbol-13-acetate responsive elements [TREs, also called activator protein 1 (AP-1) motifs].	Tetradecanoylphorbol Acetate	37-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
8797597-2	1996	c-Jun and v-Jun bind specifically to 12-O-tetradecanoylphorbol-13-acetate responsive elements [TREs, also called activator protein 1 (AP-1) motifs].	Tetradecanoylphorbol Acetate	37-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	10-15
8797597-2	1996	c-Jun and v-Jun bind specifically to 12-O-tetradecanoylphorbol-13-acetate responsive elements [TREs, also called activator protein 1 (AP-1) motifs].	Tetradecanoylphorbol Acetate	37-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-132
8797597-2	1996	c-Jun and v-Jun bind specifically to 12-O-tetradecanoylphorbol-13-acetate responsive elements [TREs, also called activator protein 1 (AP-1) motifs].	Tetradecanoylphorbol Acetate	37-73	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-138
8732291-3	1996	We have studied the effects of 12-tetradecanoyl phorbol 13-acetate (TPA) and/or dexamethasone on the expression, translocation, and secretion of lipocortin 1 in U937 cells.	Tetradecanoylphorbol Acetate	31-66	annexin A1	Homo sapiens	145-157
6319411-2	1984	Neutrophils, activated by either opsonized zymosan particles or the soluble stimulus phorbol myristate acetate, released O-2, which subsequently entered the ghosts and reduced (Fe3+)cytochrome c.	Tetradecanoylphorbol Acetate	85-110	immunoglobulin kappa variable 1D-39	Homo sapiens	121-124
8732291-3	1996	We have studied the effects of 12-tetradecanoyl phorbol 13-acetate (TPA) and/or dexamethasone on the expression, translocation, and secretion of lipocortin 1 in U937 cells.	Tetradecanoylphorbol Acetate	68-71	annexin A1	Homo sapiens	145-157
8798441-6	1996	Treatment with phorbol 12-myristate 13-acetate (PMA) led to an increase in both the amount of phosphorylated CREB and the bcl-2 promoter activity.	Tetradecanoylphorbol Acetate	15-46	cAMP responsive element binding protein 1	Homo sapiens	109-113
8805627-2	1996	Surface Ig ligation or pharmacologic stimulation with PMA and ionomycin resulted in the delayed (2-3 h after stimulation) nuclear appearance of tyrosine-phosphorylated STAT1 alpha, in contrast to the rapid induction that follows cytokine treatment.	Tetradecanoylphorbol Acetate	54-57	signal transducer and activator of transcription 1	Homo sapiens	168-173
6319411-6	1984	Human eosinophils stimulated by phorbol myristate acetate reacted similarly to human neutrophils; the rate of O-2 production/cell was about twice as high for eosinophils as for neutrophils.	Tetradecanoylphorbol Acetate	32-57	immunoglobulin kappa variable 1D-39	Homo sapiens	110-113
6319390-5	1984	Maximal phosphorylation of ribosomal protein S6 was achieved by 60 min and remained elevated for at least 90 min in the presence of TPA.	Tetradecanoylphorbol Acetate	132-135	ribosomal protein S6	Rattus norvegicus	27-47
8887775-4	1996	The PKC activators phorbol 12-myristate 14-acetate (PMA) and phorbol 12, 13-dibutyrate (PDBu) inhibited KIR2.3 currents, but not KIR2.1 or KIR1.1 current.	Tetradecanoylphorbol Acetate	52-55	potassium inwardly rectifying channel subfamily J member 1 S homeolog	Xenopus laevis	139-145
9052983-4	1996	The amount of PKC alpha RNA and protein was 6- to 38-fold lower, and PKC mu RNA was 4.5- to 16.5-fold higher in unmodified and TPA-resistant LNCaP cells than in the androgen-independent cells.	Tetradecanoylphorbol Acetate	127-130	protein kinase D1	Homo sapiens	69-75
8617996-8	1996	Although the levels of Jun and Fos gene expression did not differ from those observed in normal fibroblasts, AP-1-binding activity, as measured by the ability to bind to an oligonucleotide containing a TPA-responsive element, was significantly elevated in CL fibroblasts as compared with normal fibroblasts.	Tetradecanoylphorbol Acetate	202-205	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-34
8631823-1	1996	The B-lymphoblastoid cell line JY undergoes homotypic aggregation in a lymphocyte function-associated antigen-1 (LFA-1)-mediated, intracellular adhesion molecule-1 (ICAM-1)-dependent manner when stimulated with phorbol 12-myristate 13-acetate or anti-LFA-1 antibodies.	Tetradecanoylphorbol Acetate	211-242	intercellular adhesion molecule 1	Homo sapiens	165-171
6232432-6	1984	Immunoprecipitation, after ectolabeling of the cells with the C17 antibody and SDS-polyacrylamide gel electrophoresis, proved that TPA-induced K562 expressed both GP IIIa and GP IIb.	Tetradecanoylphorbol Acetate	131-134	integrin subunit alpha 2b	Homo sapiens	175-181
8631823-5	1996	p130cas phosphorylation was rapidly reversible upon disengagement of the LFA-1-ICAM-1 complex and required cell adhesion since binding of phorbol 12-myristate 13-acetate-stimulated JY cells to purified ICAM-1 or cross-linking of either LFA-1 or ICAM-1 was not sufficient to induce phosphorylation of p130cas.	Tetradecanoylphorbol Acetate	138-169	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	0-4
8631823-5	1996	p130cas phosphorylation was rapidly reversible upon disengagement of the LFA-1-ICAM-1 complex and required cell adhesion since binding of phorbol 12-myristate 13-acetate-stimulated JY cells to purified ICAM-1 or cross-linking of either LFA-1 or ICAM-1 was not sufficient to induce phosphorylation of p130cas.	Tetradecanoylphorbol Acetate	138-169	intercellular adhesion molecule 1	Homo sapiens	79-85
8631823-5	1996	p130cas phosphorylation was rapidly reversible upon disengagement of the LFA-1-ICAM-1 complex and required cell adhesion since binding of phorbol 12-myristate 13-acetate-stimulated JY cells to purified ICAM-1 or cross-linking of either LFA-1 or ICAM-1 was not sufficient to induce phosphorylation of p130cas.	Tetradecanoylphorbol Acetate	138-169	intercellular adhesion molecule 1	Homo sapiens	202-208
8631823-5	1996	p130cas phosphorylation was rapidly reversible upon disengagement of the LFA-1-ICAM-1 complex and required cell adhesion since binding of phorbol 12-myristate 13-acetate-stimulated JY cells to purified ICAM-1 or cross-linking of either LFA-1 or ICAM-1 was not sufficient to induce phosphorylation of p130cas.	Tetradecanoylphorbol Acetate	138-169	intercellular adhesion molecule 1	Homo sapiens	202-208
8879350-1	1996	The PKC activators phorbol 12-myristate 13-acetate (PMA) and 1-oleoyl 2-acetyl glycerol (OAG) stimulated CNP release; the maximal effects were apparent at 4 h, at which time release was 934 and 205% of the control value, respectively.	Tetradecanoylphorbol Acetate	19-50	natriuretic peptide C	Homo sapiens	105-108
8879350-1	1996	The PKC activators phorbol 12-myristate 13-acetate (PMA) and 1-oleoyl 2-acetyl glycerol (OAG) stimulated CNP release; the maximal effects were apparent at 4 h, at which time release was 934 and 205% of the control value, respectively.	Tetradecanoylphorbol Acetate	52-55	natriuretic peptide C	Homo sapiens	105-108
8879350-2	1996	The PKC inhibitors staurosporine and H-7 did not affect basal CNP release, but each abolished the increase in CNP release induced by PMA or OAG.	Tetradecanoylphorbol Acetate	133-136	natriuretic peptide C	Homo sapiens	110-113
6352806-1	1983	A subline of the C57BL/6 mouse EL-4 thymoma produces upon stimulation with phorbol myristate acetate (PMA) a B cell growth factor (BCGF) that co-stimulates anti-IgM-stimulated splenic B cells.	Tetradecanoylphorbol Acetate	75-100	epilepsy 4	Mus musculus	31-35
8877133-4	1996	For ACH-2 cells stimulated with phorbol 12-myristate 13-acetate (PMA; 50 ng/ml), IL-12 and IL-15 significantly increased p24 antigen production by 20 and 30%, respectively (n = 6).	Tetradecanoylphorbol Acetate	32-63	acyl-CoA thioesterase 1	Homo sapiens	4-9
8877133-4	1996	For ACH-2 cells stimulated with phorbol 12-myristate 13-acetate (PMA; 50 ng/ml), IL-12 and IL-15 significantly increased p24 antigen production by 20 and 30%, respectively (n = 6).	Tetradecanoylphorbol Acetate	32-63	interleukin 15	Homo sapiens	91-96
8877133-4	1996	For ACH-2 cells stimulated with phorbol 12-myristate 13-acetate (PMA; 50 ng/ml), IL-12 and IL-15 significantly increased p24 antigen production by 20 and 30%, respectively (n = 6).	Tetradecanoylphorbol Acetate	65-68	acyl-CoA thioesterase 1	Homo sapiens	4-9
8877133-4	1996	For ACH-2 cells stimulated with phorbol 12-myristate 13-acetate (PMA; 50 ng/ml), IL-12 and IL-15 significantly increased p24 antigen production by 20 and 30%, respectively (n = 6).	Tetradecanoylphorbol Acetate	65-68	interleukin 15	Homo sapiens	91-96
8814250-6	1996	Functional helper T cells (Th1 and Th2) were induced from the CD4 lineage-committed cells upon secondary stimulation with a combination of ionomycin and PMA followed by lymphokine treatment.	Tetradecanoylphorbol Acetate	153-156	CD4 antigen	Mus musculus	62-65
8636079-2	1996	We demonstrate here that TPA stimulation increases tyrosine phosphorylation of an 80-kDa protein at an early stage of megakaryocytic differentiation and that this 80-kDa protein is identical with cortactin.	Tetradecanoylphorbol Acetate	25-28	cortactin	Homo sapiens	196-205
8636079-3	1996	Since tyrosine kinase Syk was activated by TPA stimulation, we examined the possibility that cortactin is a potential substrate of Syk in K562 cells.	Tetradecanoylphorbol Acetate	43-46	spleen associated tyrosine kinase	Homo sapiens	22-25
8636079-4	1996	TPA-induced tyrosine phosphorylation of cortactin was decreased profoundly by overexpression of dominant-negative Syk.	Tetradecanoylphorbol Acetate	0-3	cortactin	Homo sapiens	40-49
8636079-4	1996	TPA-induced tyrosine phosphorylation of cortactin was decreased profoundly by overexpression of dominant-negative Syk.	Tetradecanoylphorbol Acetate	0-3	spleen associated tyrosine kinase	Homo sapiens	114-117
8636079-7	1996	These data suggest that Syk phosphorylates cortactin in K562 cells upon TPA treatment.	Tetradecanoylphorbol Acetate	72-75	spleen associated tyrosine kinase	Homo sapiens	24-27
8636079-7	1996	These data suggest that Syk phosphorylates cortactin in K562 cells upon TPA treatment.	Tetradecanoylphorbol Acetate	72-75	cortactin	Homo sapiens	43-52
8794869-5	1996	Cells depleted of phorbol 12-myristate 13-acetate (PMA)-inducible PKCs by chronic treatment with PMA still demonstrated an alpha 2 response to PDGF indicating that a non-PMA-sensitive PKC isoform was required.	Tetradecanoylphorbol Acetate	18-49	protein kinase C zeta	Homo sapiens	66-69
6352806-1	1983	A subline of the C57BL/6 mouse EL-4 thymoma produces upon stimulation with phorbol myristate acetate (PMA) a B cell growth factor (BCGF) that co-stimulates anti-IgM-stimulated splenic B cells.	Tetradecanoylphorbol Acetate	102-105	epilepsy 4	Mus musculus	31-35
8794869-5	1996	Cells depleted of phorbol 12-myristate 13-acetate (PMA)-inducible PKCs by chronic treatment with PMA still demonstrated an alpha 2 response to PDGF indicating that a non-PMA-sensitive PKC isoform was required.	Tetradecanoylphorbol Acetate	51-54	protein kinase C zeta	Homo sapiens	66-69
6578050-7	1983	Differentiation of C12 cells by RA and TPA was similar to that observed with native HL60 cells, whereas C13 cells showed lower degrees of sensitivity to RA and TPA.	Tetradecanoylphorbol Acetate	160-163	homeobox C13	Homo sapiens	104-107
8794869-5	1996	Cells depleted of phorbol 12-myristate 13-acetate (PMA)-inducible PKCs by chronic treatment with PMA still demonstrated an alpha 2 response to PDGF indicating that a non-PMA-sensitive PKC isoform was required.	Tetradecanoylphorbol Acetate	97-100	protein kinase C zeta	Homo sapiens	66-69
8864900-8	1996	A 24 h pretreatment with PMA at 10(-7) M inhibited the mitogenic response, tyrosine phosphorylation of MAPK, and induction of c-fos mRNA subsequent to the addition of PMA, but not bFGF.	Tetradecanoylphorbol Acetate	25-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	126-131
8864900-8	1996	A 24 h pretreatment with PMA at 10(-7) M inhibited the mitogenic response, tyrosine phosphorylation of MAPK, and induction of c-fos mRNA subsequent to the addition of PMA, but not bFGF.	Tetradecanoylphorbol Acetate	167-170	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	126-131
8630387-5	1996	Phorbol myristate acetate, a promoter of monocytic differentiation in HL-60 cells, also caused a significant increase in NK-TR1 over basal levels.	Tetradecanoylphorbol Acetate	0-25	thioredoxin reductase 1	Homo sapiens	124-127
6850576-0	1983	Inhibition by 2(3)-tert-butyl-4-hydroxyanisole and other antioxidants of epidermal ornithine decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	127-163	ornithine decarboxylase, structural 1	Mus musculus	83-106
8690892-2	1996	Moreover, phorbol esters such as PMA, which can activate cPLA2 via mitogen-activated protein (MAP) kinase in most cell types, also failed to induce the release of arachidonate from mature cells, suggesting that the cPLA2 pathway may not be functional in mature lymphocytes.	Tetradecanoylphorbol Acetate	33-36	phospholipase A2 group IVA	Homo sapiens	57-62
8865287-1	1996	The production of IL-10 by human neonatal blood mononuclear leukocytes (BML) stimulated with lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-alpha), antibodies to CD3, or phorbol 12-myristate 13-acetate (PMA) was measured.	Tetradecanoylphorbol Acetate	182-213	interleukin 10	Homo sapiens	18-23
6850576-1	1983	The relationship between reactive oxygen and/or free radical species and tumor promotion was evaluated by investigating the inhibitory effects of 2(3)-tert-butyl-4-hydroxyanisole (BHA) and other antioxidants on the induction of ornithine decarboxylase (ODC) activity in mouse epidermis by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	307-343	ornithine decarboxylase, structural 1	Mus musculus	228-251
8865287-1	1996	The production of IL-10 by human neonatal blood mononuclear leukocytes (BML) stimulated with lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-alpha), antibodies to CD3, or phorbol 12-myristate 13-acetate (PMA) was measured.	Tetradecanoylphorbol Acetate	215-218	interleukin 10	Homo sapiens	18-23
6850576-1	1983	The relationship between reactive oxygen and/or free radical species and tumor promotion was evaluated by investigating the inhibitory effects of 2(3)-tert-butyl-4-hydroxyanisole (BHA) and other antioxidants on the induction of ornithine decarboxylase (ODC) activity in mouse epidermis by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	345-348	ornithine decarboxylase, structural 1	Mus musculus	228-251
8616013-5	1996	Western blot analysis of nuclear lysates consistently showed a significant increase of PKC-alpha, -beta I, -epsilon, theta and -zeta isoforms after 30 min of PMA treatment, followed by a drastic decline of all but PKC-zeta isoforms.	Tetradecanoylphorbol Acetate	158-161	protein kinase C zeta	Homo sapiens	214-222
6220085-11	1983	A second T cell cytotoxicity-inducing factor (TCF2) was pH 2-sensitive and was found in Con A-induced spleen cell supernatants as well as in interferon-free supernatants of PMA-stimulated EL-4 cells.	Tetradecanoylphorbol Acetate	173-176	HNF1 homeobox B	Mus musculus	46-50
8640756-6	1996	Preapplication of GE onto the skin of SENCAR mice resulted in significant inhibition of 12-0-tetradecanoylphorbol-13-acetate (TPA)-caused induction of epidermal ODC, cyclooxygenase, and lipoxygenase activities and ODC mRNA expression in a does-dependent manner.	Tetradecanoylphorbol Acetate	126-129	ornithine decarboxylase, structural 1	Mus musculus	214-217
8783199-6	1996	Here the effects of CNTF, which did not induce neural differentiation, were enhanced by differentiation with 12-O-tetradecanoylphorbol 13-acetate (10 nM) and prevented by retinoic acid (10 microM).	Tetradecanoylphorbol Acetate	109-145	ciliary neurotrophic factor	Homo sapiens	20-24
8761294-6	1996	Interestingly, expression of PKC-delta K376R strongly reduced TPA responsive element (TRE) transactivation induced by PDGF stimulation, suggesting that activation of TRE-containing genes, which may be involved in Sis-mediated transformation, are negatively regulated by expression of PKC-delta K376R.	Tetradecanoylphorbol Acetate	62-65	protein kinase C, delta	Mus musculus	29-38
8761308-4	1996	Nested-deletion analyses showed that the SPE was required for TPA-inducibility of c-sis/PDGF-B transcription.	Tetradecanoylphorbol Acetate	62-65	platelet derived growth factor subunit B	Homo sapiens	82-87
8761308-4	1996	Nested-deletion analyses showed that the SPE was required for TPA-inducibility of c-sis/PDGF-B transcription.	Tetradecanoylphorbol Acetate	62-65	platelet derived growth factor subunit B	Homo sapiens	88-94
8663336-5	1996	The down-regulation of PKC by growing mesangial cells in the presence of phorbol 12-myristate 13-acetate for 24 h failed to modify the up-regulated response in PGE2 formation by IL-1beta.	Tetradecanoylphorbol Acetate	73-104	protein kinase C zeta	Homo sapiens	23-26
8703996-1	1996	The effect of phorbol 12-myristate 13-acetate (PMA) on the expression and shedding of intercellular adhesion molecule-1 (ICAM-1) was investigated on the hematopoietic cell lines K 562 and U 937 using flow cytometry, fluorescence microscopy and ELISA technique.	Tetradecanoylphorbol Acetate	14-45	intercellular adhesion molecule 1	Homo sapiens	86-119
6601774-3	1983	In this report we describe the direct induction of IgM synthesis and secretion in cloned lines of long-term tissue culture adapted neoplastic B cells (BCL1) by T-cell supernatants from phorbol-12-myristate 13-acetate (PMA)-induced EL-4 cells or concanavalin A (Con A)-induced 7.1.1a cells5,9.	Tetradecanoylphorbol Acetate	185-216	immunoglobulin heavy constant mu	Mus musculus	51-54
8760041-6	1996	Superfusion of the PKC activator phorbol 12-myristate 13-acetate produced effects on IK and ICa similar to those observed after ANG II.	Tetradecanoylphorbol Acetate	33-64	protein kinase C, gamma	Rattus norvegicus	19-22
8652841-5	1996	Stimulation of mouse B cells with anti-IgM or IgD antibodies, bacterial lipopolysaccharide, phorbol 12-myristate 13-acetate plus ionomycin, or CD40 ligand led to a five-fold to 35-fold decrease in BCL-6 mRNA levels.	Tetradecanoylphorbol Acetate	92-123	B cell leukemia/lymphoma 6	Mus musculus	197-202
8652844-6	1996	To better define the role of MAPKAP kinase 2 in the activation of human neutrophils, its enzymatic activity was measured after stimulation by either a phorbol ester (phorbol myristate acetate [PMA]), a potent protein kinase C activator, or the tripeptide fMLP, which is a chemotactic factor.	Tetradecanoylphorbol Acetate	166-191	MAPK activated protein kinase 2	Homo sapiens	29-44
6601774-3	1983	In this report we describe the direct induction of IgM synthesis and secretion in cloned lines of long-term tissue culture adapted neoplastic B cells (BCL1) by T-cell supernatants from phorbol-12-myristate 13-acetate (PMA)-induced EL-4 cells or concanavalin A (Con A)-induced 7.1.1a cells5,9.	Tetradecanoylphorbol Acetate	185-216	cyclin D1	Mus musculus	151-155
8652844-6	1996	To better define the role of MAPKAP kinase 2 in the activation of human neutrophils, its enzymatic activity was measured after stimulation by either a phorbol ester (phorbol myristate acetate [PMA]), a potent protein kinase C activator, or the tripeptide fMLP, which is a chemotactic factor.	Tetradecanoylphorbol Acetate	193-196	MAPK activated protein kinase 2	Homo sapiens	29-44
6601774-3	1983	In this report we describe the direct induction of IgM synthesis and secretion in cloned lines of long-term tissue culture adapted neoplastic B cells (BCL1) by T-cell supernatants from phorbol-12-myristate 13-acetate (PMA)-induced EL-4 cells or concanavalin A (Con A)-induced 7.1.1a cells5,9.	Tetradecanoylphorbol Acetate	218-221	immunoglobulin heavy constant mu	Mus musculus	51-54
8654580-3	1996	The Fos and Jun components of AP1 were induced rapidly and transiently in PC12 cells following the addition of phorbol ester (phorbol 12-myristate 13-acetate, PMA).	Tetradecanoylphorbol Acetate	126-157	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	4-7
6601774-3	1983	In this report we describe the direct induction of IgM synthesis and secretion in cloned lines of long-term tissue culture adapted neoplastic B cells (BCL1) by T-cell supernatants from phorbol-12-myristate 13-acetate (PMA)-induced EL-4 cells or concanavalin A (Con A)-induced 7.1.1a cells5,9.	Tetradecanoylphorbol Acetate	218-221	cyclin D1	Mus musculus	151-155
8654580-3	1996	The Fos and Jun components of AP1 were induced rapidly and transiently in PC12 cells following the addition of phorbol ester (phorbol 12-myristate 13-acetate, PMA).	Tetradecanoylphorbol Acetate	159-162	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	4-7
6601110-3	1983	Low concentrations of glucocorticoids and also prostaglandins E1 and E2 suppress both the CSF-1-stimulated and the TPA-stimulated macrophage DNA synthesis; these same drugs inhibit the CSF-1-mediated and TPA-mediated enhancement of macrophage plasminogen activator (PA) activity.	Tetradecanoylphorbol Acetate	115-118	colony stimulating factor 1 (macrophage)	Mus musculus	185-190
8639843-4	1996	In highly purified CD4+ T cells, IFN-alpha upregulated IL-10 mRNA upon activation with phytohemagglutinin and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	110-135	interleukin 10	Homo sapiens	55-60
6601131-4	1983	As a consequence of TPA treatment, resistance to dGuo is observed in 8402, as well as in two other TdT+ lymphoid T cell lines, Molt-4 and CEM-10.	Tetradecanoylphorbol Acetate	20-23	DNA nucleotidylexotransferase	Homo sapiens	99-102
8703801-9	1996	Although PKC zeta was resistant to TPA treatment and its translocation was reduced, the amount of this isozyme in the cytosol fraction decreased throughout the differentiation process.	Tetradecanoylphorbol Acetate	35-38	protein kinase C zeta	Homo sapiens	9-17
6884565-0	1983	Purification of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase from mouse epidermis.	Tetradecanoylphorbol Acetate	16-52	ornithine decarboxylase, structural 1	Mus musculus	61-84
9099936-10	1996	Both spontaneous and up-regulated expression of ICAM-1, LFA-3 and VCAM-1 by IFN-gamma, IL-1beta or 12-o-tetradecanoyl phorbol 13-acetate (TPA) were markedly suppressed by clarithromycin in a dose-dependent manner at concentrations between 0.1 and 10 microg/ml.	Tetradecanoylphorbol Acetate	99-136	intercellular adhesion molecule 1	Homo sapiens	48-54
9099936-10	1996	Both spontaneous and up-regulated expression of ICAM-1, LFA-3 and VCAM-1 by IFN-gamma, IL-1beta or 12-o-tetradecanoyl phorbol 13-acetate (TPA) were markedly suppressed by clarithromycin in a dose-dependent manner at concentrations between 0.1 and 10 microg/ml.	Tetradecanoylphorbol Acetate	138-141	intercellular adhesion molecule 1	Homo sapiens	48-54
6884565-1	1983	Ornithine decarboxylase was purified at least 1500-fold from mouse epidermis pretreated with five consecutive doses of 12-O-tetradecanoylphorbol-13-acetate and 3-isobutyl-1-methylxanthine at 3- to 4-day intervals.	Tetradecanoylphorbol Acetate	119-155	ornithine decarboxylase, structural 1	Mus musculus	0-23
8641191-2	1996	Both 8-Br-cAMP and TPA increased plasma ACTH concentrations and the POMC messenger RNA (mRNA) concentrations in the anterior pituitary.	Tetradecanoylphorbol Acetate	19-22	proopiomelanocortin	Rattus norvegicus	68-72
7152673-1	1982	The cytochrome b 245 of human neutrophils was reduced when the neutrophils under anaerobic conditions were stimulated by serum-treated zymosan, immune complexes, or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	165-190	mitochondrially encoded cytochrome b	Homo sapiens	4-16
8647210-3	1996	Lipopolysaccharide (LPS)- or phorbol 12-myristate 13-acetate (PMA)-stimulated monocytes derived from peripheral blood of healthy donors also induced decreased expression of CD3 and CD16-associated zeta chains similar to that observed in T cells and natural killer (NK) cells of patients with advanced cancer.	Tetradecanoylphorbol Acetate	29-60	Fc gamma receptor IIIa	Homo sapiens	181-185
8647210-3	1996	Lipopolysaccharide (LPS)- or phorbol 12-myristate 13-acetate (PMA)-stimulated monocytes derived from peripheral blood of healthy donors also induced decreased expression of CD3 and CD16-associated zeta chains similar to that observed in T cells and natural killer (NK) cells of patients with advanced cancer.	Tetradecanoylphorbol Acetate	62-65	Fc gamma receptor IIIa	Homo sapiens	181-185
6959135-1	1982	Addition of 12-tetradecanoylphorbol 13-acetate (TPA) to cultures of intact Swiss mouse 3T3 fibroblasts induced a dose-dependent increase in ornithine decarboxylase (OrnDCase) activity.	Tetradecanoylphorbol Acetate	12-46	ornithine decarboxylase, structural 1	Mus musculus	165-173
8804936-8	1996	On resting AMs, the surface expression of CD11b/CD18 was significantly higher (p &lt; 0.01) compared to resting BMs but did not increase further upon activation with fMLP, PMA or ionomycin.	Tetradecanoylphorbol Acetate	172-175	integrin subunit alpha M	Homo sapiens	42-47
6959135-1	1982	Addition of 12-tetradecanoylphorbol 13-acetate (TPA) to cultures of intact Swiss mouse 3T3 fibroblasts induced a dose-dependent increase in ornithine decarboxylase (OrnDCase) activity.	Tetradecanoylphorbol Acetate	48-51	ornithine decarboxylase, structural 1	Mus musculus	140-163
8793801-4	1996	Phorbol myristate acetate (PMA), a protein kinase C (PKC) activator, increased MCP-1 message by mesangial cells while depleting PKC decreased MCP-1 gene expression to control levels.	Tetradecanoylphorbol Acetate	0-25	chemokine (C-C motif) ligand 2	Mus musculus	79-84
8793801-4	1996	Phorbol myristate acetate (PMA), a protein kinase C (PKC) activator, increased MCP-1 message by mesangial cells while depleting PKC decreased MCP-1 gene expression to control levels.	Tetradecanoylphorbol Acetate	0-25	chemokine (C-C motif) ligand 2	Mus musculus	142-147
6959135-1	1982	Addition of 12-tetradecanoylphorbol 13-acetate (TPA) to cultures of intact Swiss mouse 3T3 fibroblasts induced a dose-dependent increase in ornithine decarboxylase (OrnDCase) activity.	Tetradecanoylphorbol Acetate	48-51	ornithine decarboxylase, structural 1	Mus musculus	165-173
8793801-4	1996	Phorbol myristate acetate (PMA), a protein kinase C (PKC) activator, increased MCP-1 message by mesangial cells while depleting PKC decreased MCP-1 gene expression to control levels.	Tetradecanoylphorbol Acetate	27-30	chemokine (C-C motif) ligand 2	Mus musculus	79-84
8793801-4	1996	Phorbol myristate acetate (PMA), a protein kinase C (PKC) activator, increased MCP-1 message by mesangial cells while depleting PKC decreased MCP-1 gene expression to control levels.	Tetradecanoylphorbol Acetate	27-30	chemokine (C-C motif) ligand 2	Mus musculus	142-147
6805948-4	1982	Treatment of mice with tetracaine (20 and 100 mumol/mouse), a nonspecific phospholipase A2 inhibitor, inhibited the induction of ODC by TPA.	Tetradecanoylphorbol Acetate	136-139	phospholipase A2, group IB, pancreas	Mus musculus	74-90
6805948-4	1982	Treatment of mice with tetracaine (20 and 100 mumol/mouse), a nonspecific phospholipase A2 inhibitor, inhibited the induction of ODC by TPA.	Tetradecanoylphorbol Acetate	136-139	ornithine decarboxylase, structural 1	Mus musculus	129-132
8661513-6	1996	This remaining exchanger activity was mostly mediated via NHE-3 as shown by inhibition of the Na influx following PKC stimulation (65% with PMA vs. 100% without PMA.	Tetradecanoylphorbol Acetate	140-143	solute carrier family 9 member A3	Sus scrofa	58-63
8661513-6	1996	This remaining exchanger activity was mostly mediated via NHE-3 as shown by inhibition of the Na influx following PKC stimulation (65% with PMA vs. 100% without PMA.	Tetradecanoylphorbol Acetate	161-164	solute carrier family 9 member A3	Sus scrofa	58-63
6805948-6	1982	The TPA-induced ODC inhibited by mepacrine was not restored by the treatment of mice with PGE2.	Tetradecanoylphorbol Acetate	4-7	ornithine decarboxylase, structural 1	Mus musculus	16-19
6805948-7	1982	TPA-induced ODC inhibited by either mepacrine or p-bromophenacyl bromide was partially but significantly restored by treatment with arachidonic acid (1 to 40 mumol/mouse).	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	12-15
6805948-9	1982	Treatment of mice with nordihydroguaiaretic acid (10 to 90 mumol/mouse), a lipoxygenase inhibitor, also inhibited the induction of ODC by TPA.	Tetradecanoylphorbol Acetate	138-141	ornithine decarboxylase, structural 1	Mus musculus	131-134
8667229-6	1996	Exogenous arachidonic acid also inhibited TPA-induced PAF production in parallel with increase in PGE2 levels.	Tetradecanoylphorbol Acetate	42-45	PCNA clamp associated factor	Rattus norvegicus	54-57
6805948-10	1982	These results strongly indicate that the stimulation of phospholipase A2 activity is a crucial process in inducing mouse epidermal ODC by TPA and not only cyclooxygenase product (i.e., PGE2) but also lipoxygenase product(s) are involved in the mechanism of ODC induction.	Tetradecanoylphorbol Acetate	138-141	phospholipase A2, group IB, pancreas	Mus musculus	56-72
8658534-2	1996	The CD4+ cultures were stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin to activate protein kinase C and increase cytoplasmic free calcium, respectively, in a range of VT concentrations.	Tetradecanoylphorbol Acetate	39-70	CD4 antigen	Mus musculus	4-7
8658534-2	1996	The CD4+ cultures were stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin to activate protein kinase C and increase cytoplasmic free calcium, respectively, in a range of VT concentrations.	Tetradecanoylphorbol Acetate	72-75	CD4 antigen	Mus musculus	4-7
6805948-10	1982	These results strongly indicate that the stimulation of phospholipase A2 activity is a crucial process in inducing mouse epidermal ODC by TPA and not only cyclooxygenase product (i.e., PGE2) but also lipoxygenase product(s) are involved in the mechanism of ODC induction.	Tetradecanoylphorbol Acetate	138-141	ornithine decarboxylase, structural 1	Mus musculus	131-134
8658534-13	1996	Taken together, VT enhanced and/or delayed peak IL-2, IL-4, and IL-5 gene expression and secretion in CD4+ T cells stimulated with PMA and ionomycin.	Tetradecanoylphorbol Acetate	131-134	CD4 antigen	Mus musculus	102-105
6805948-11	1982	Our present data also suggest that the above arachidonate metabolites are essential but not sufficient factors for the TPA-stimulated induction of ODC.	Tetradecanoylphorbol Acetate	119-122	ornithine decarboxylase, structural 1	Mus musculus	147-150
7116338-1	1982	The effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) and 3-methyl-cholanthrene (MC) on ornithine decarboxylase (ODC) and aryl hydrocarbon hydroxylase (AHH) activities were studied in C57BL/6 mouse dermal fibroblasts in culture.	Tetradecanoylphorbol Acetate	15-51	ornithine decarboxylase, structural 1	Mus musculus	92-115
8649860-6	1996	Two of these sites were differentially observed in cells displaying high and low TGFalpha gene transcription, while a third site correlated with TPA-induced expression.	Tetradecanoylphorbol Acetate	145-148	transforming growth factor alpha	Rattus norvegicus	81-89
7116338-1	1982	The effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) and 3-methyl-cholanthrene (MC) on ornithine decarboxylase (ODC) and aryl hydrocarbon hydroxylase (AHH) activities were studied in C57BL/6 mouse dermal fibroblasts in culture.	Tetradecanoylphorbol Acetate	53-56	ornithine decarboxylase, structural 1	Mus musculus	92-115
7116338-2	1982	TPA selectively induced ODC activity and MC selectively induced AHH activity in these cells.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	24-27
6951664-6	1982	In one of these three ALL cases the population of TdT-positive cells and the TdT activity of the blasts decreased significantly after culture with TPA.	Tetradecanoylphorbol Acetate	147-150	DNA nucleotidylexotransferase	Homo sapiens	50-53
8799468-0	1996	Gingko biloba extract EGb 761 is a suppresser of AP-1 transcription factor stimulated by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	89-120	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-53
8733584-6	1996	PKC-alpha was largely cytosolic in unstimulated cells and almost all translocated to the membrane (Triton X-100 soluble) after a 1 min treatment with the PKC activating phorbol myristate acetate (PMA); PKC-epsilon was always in a Triton X-100 insoluble membrane fraction, while PKC-zeta was found in both soluble and membrane bound (Triton X-100 soluble) forms in the unstimulated cells and was unaffected by PMA.	Tetradecanoylphorbol Acetate	196-199	protein kinase C alpha	Bos taurus	0-9
8733584-8	1996	Treatment with PMA for 6 h led to a 90% downregulation of PKC-alpha, while the immunoreactivity to the epsilon and zeta isoforms remained largely unchanged.	Tetradecanoylphorbol Acetate	15-18	protein kinase C alpha	Bos taurus	58-67
6951664-6	1982	In one of these three ALL cases the population of TdT-positive cells and the TdT activity of the blasts decreased significantly after culture with TPA.	Tetradecanoylphorbol Acetate	147-150	DNA nucleotidylexotransferase	Homo sapiens	77-80
8733584-11	1996	Thus the PGI2 response to PMA under conditions when 90% of the PKC-alpha was lost resembles that seen on acute stimulation of PKC by PMA, and the PGI2 response does not correlate with phospholipase C response.	Tetradecanoylphorbol Acetate	26-29	protein kinase C alpha	Bos taurus	63-72
6817941-0	1982	Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by lipoxygenase inhibitors: possible role of product(s) of lipoxygenase pathway.	Tetradecanoylphorbol Acetate	14-50	ornithine decarboxylase, structural 1	Mus musculus	69-92
8616873-1	1996	Both TPA and A23187 dramatically enhanced MDA-MB-435 cell adhesion to type IV collagen (collagen IV), vitronectin, and, to some extent, fibronectin and laminin.	Tetradecanoylphorbol Acetate	5-8	vitronectin	Homo sapiens	102-113
8616873-7	1996	Calphostin C, a PKC inhibitor, blocked the stimulation of adhesion by A23187, exogenous AA, and TPA to both collagen IV and vitronectin.	Tetradecanoylphorbol Acetate	96-99	vitronectin	Homo sapiens	124-135
8620603-12	1996	For additional comparison, c-fos expression was induced by Ang II and phorbol myristate acetate, which did not induce exchanger expression; conversely, exchanger expression was induced by veratridine, which did not increase c-fos expression.	Tetradecanoylphorbol Acetate	70-95	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-32
6817941-3	1982	Inhibition of TPA-induced ODC by indomethacin (1.12 mumol/mouse), a selective cyclooxygenase inhibitor, was counteracted by prostaglandin E2 (PGE2) (140 nmol/mouse).	Tetradecanoylphorbol Acetate	14-17	ornithine decarboxylase, structural 1	Mus musculus	26-29
8647171-4	1996	The resulting CD4+ T cell clones generated under these different experimental conditions were then analyzed for their ability to produce IL-2, IL-4, IL-5, IL-10, IFN-gamma and tumor necrosis factor (TNF)-beta in response to stimulation with phorbol 12-myristate 13-acetate (PMA) + anti-CD3 monoclonal antibody or PMA + ionomycin.	Tetradecanoylphorbol Acetate	241-272	lymphotoxin alpha	Homo sapiens	176-208
6817941-7	1982	Thus, the suppressive effect of nordihydroguaiaretic acid or phenidone on the ODC induction by TPA would be due to the inhibition of lipoxygenase.	Tetradecanoylphorbol Acetate	95-98	ornithine decarboxylase, structural 1	Mus musculus	78-81
8613475-4	1996	TPA treatment of HT1080 cells induced the expression of interstitial collagenase (MMP-1) and increased the expression of gelatinase B (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), and MT-MMP, a membrane-bound activator of progelatinase A (proMMP-2), while MMP-2 and TIMP-2 expression were decreased.	Tetradecanoylphorbol Acetate	0-3	TIMP metallopeptidase inhibitor 2	Homo sapiens	280-286
7083472-4	1982	Retinoic acid inhibited the TPA-induced ODC activity and the ensuing accumulation of putrescine, but did not alter the TPA-induced SAM-D activity or the molar ratio of spermidine/spermine.	Tetradecanoylphorbol Acetate	28-31	ornithine decarboxylase, structural 1	Mus musculus	40-43
8780012-2	1996	To explore the role of protein kinase C (PKC) in this action of NGF, PKC was down-regulated by long-term treatment of the cells with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	133-164	protein kinase C, alpha	Rattus norvegicus	41-44
8780012-2	1996	To explore the role of protein kinase C (PKC) in this action of NGF, PKC was down-regulated by long-term treatment of the cells with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	133-164	protein kinase C, alpha	Rattus norvegicus	69-72
8780012-2	1996	To explore the role of protein kinase C (PKC) in this action of NGF, PKC was down-regulated by long-term treatment of the cells with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	166-169	protein kinase C, alpha	Rattus norvegicus	69-72
7083472-7	1982	Hence, at four levels of retinoic acid (0.17, 1.70, 17.0 and 170 nmol), which all inhibited the TPA-induced ODC effectively, there was no change in the total number of basal cells that divided during 16-48 h after TPA-application.	Tetradecanoylphorbol Acetate	96-99	ornithine decarboxylase, structural 1	Mus musculus	108-111
8780012-5	1996	These data, as well as that PMA alone can induce AA release in PC12 cells, suggest that PKC is necessary for NGF-induced AA release.	Tetradecanoylphorbol Acetate	28-31	protein kinase C, alpha	Rattus norvegicus	88-91
7295793-0	1981	Characterization of arginase activity from mouse epidermis and its relation to ornithine decarboxylase induction by the tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	143-179	ornithine decarboxylase, structural 1	Mus musculus	79-102
8622882-7	1996	Gel shift assays demonstrated the mobility pattern of TPA-responsive element (TRE) binding complex with AP-1 derived from H-ras transfectants migrated faster than those from Balb-Neo1, v-myc and H-ras/v-myc.	Tetradecanoylphorbol Acetate	54-57	Harvey rat sarcoma virus oncogene	Mus musculus	122-127
6976970-2	1981	It was found that the induction process by TPA, which included increase in cells with receptors to sheep red blood cells (E--rosette positive--E+) and decrease in the levels of the marker enzyme terminal deoxynucleotidyl transferase (TdT) was not affected by the presence of DNA synthesis inhibitor arabinofuranosylcytosine (Ara-C).	Tetradecanoylphorbol Acetate	43-46	DNA nucleotidylexotransferase	Homo sapiens	234-237
8622882-7	1996	Gel shift assays demonstrated the mobility pattern of TPA-responsive element (TRE) binding complex with AP-1 derived from H-ras transfectants migrated faster than those from Balb-Neo1, v-myc and H-ras/v-myc.	Tetradecanoylphorbol Acetate	54-57	Harvey rat sarcoma virus oncogene	Mus musculus	195-200
8700159-3	1996	However, a superinduction of ODC activity (approximately 13 CO2/60 min/mg protein) is observed upon the second TPA application at 48 or 72 h after the first TPA treatment.	Tetradecanoylphorbol Acetate	157-160	ornithine decarboxylase, structural 1	Mus musculus	29-32
8700159-0	1996	Superinduction of mouse epidermal ornithine decarboxylase activity by repeated 12-o-tetradecanoylphorbol-13-acetate treatments.	Tetradecanoylphorbol Acetate	79-115	ornithine decarboxylase, structural 1	Mus musculus	34-57
8700159-1	1996	A correlation of the levels of epidermal protein kinase C (PKC) isozymes, steady state levels of ornithine decarboxylase (ODC) mRNA, and ODC antizyme with the induction of ornithine decarboxylase (ODC) activity by a second repeat 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment to mouse skin was determined.	Tetradecanoylphorbol Acetate	230-266	ornithine decarboxylase, structural 1	Mus musculus	172-195
8739233-2	1996	Under dual whole-cell voltage-clamp, PKC activation by 100 nM TPA increased g(j) by 16 +/- 2% (mean +/- S.E.M, n = 9), 1.5 mM of the PKG activator 8-bromo-cGMP (8Br-cGMP) decreased g(j) by 26 +/- 2% (n = 4), whereas 1.5 mM of the PKA activator 8Br-cAMP did not affect g(j) (1 +/- 5%, n = 11).	Tetradecanoylphorbol Acetate	62-65	protein kinase C, gamma	Rattus norvegicus	37-40
6976970-4	1981	The kinetics of the increased in E+ cells, decrease in the levels of TdT in these cells, or decrease in the ability to proliferate as measured by colony formation were similar with exposure to TPA for 1, 6, 24, or 96 hours.	Tetradecanoylphorbol Acetate	193-196	DNA nucleotidylexotransferase	Homo sapiens	69-72
6261139-3	1981	The recently discovered class of tumour promoters, the teleocidins, are as potent as TPA in the induction of ornithine decarboxylase in mouse skin, the inhibition of differentiation of Friend erythroleukaemia cells, the induction of HL-60 cell adhesion and the promotion of tumours on mouse skin.	Tetradecanoylphorbol Acetate	85-88	ornithine decarboxylase, structural 1	Mus musculus	109-132
8613261-4	1996	Kinetic analyses indicated that whereas 12-O-tetradecanoylphorbol 13-acetate increased the maximal transport capacity of NHE-1 in both cell types, affinity for H+ was increased in WKY cells and cooperativity for H+ at the internal modifier site was reduced in SHR cells.	Tetradecanoylphorbol Acetate	40-76	solute carrier family 9 member A1	Rattus norvegicus	121-126
8564984-2	1996	In this study, we show that palytoxin, a potent non-12-O-tetradecanoylphorbol-13-acetate (TPA)-type skin tumor promoter, induces a signaling pathway leading to the activation of the stress-activated protein kinases/c-Jun N-terminal kinases (JNK) in Swiss 3T3 fibroblasts.	Tetradecanoylphorbol Acetate	90-93	mitogen-activated protein kinase 8	Mus musculus	241-244
21153286-1	1996	The objective of this study was to investigate the effect of the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) on FSH- and LH-induced 3beta-HSD-gene expression in cultured porcine granulosa cells.	Tetradecanoylphorbol Acetate	95-126	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	156-165
21153286-1	1996	The objective of this study was to investigate the effect of the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) on FSH- and LH-induced 3beta-HSD-gene expression in cultured porcine granulosa cells.	Tetradecanoylphorbol Acetate	128-131	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	156-165
21153286-5	1996	When granulosa cells were treated with PMA (100 nM) just before the addition of FSH, the 3beta-HSD rnRNA levels induced by 10 or 30 ng/mL of FSH were inhibited or partially inhibited, respectively.	Tetradecanoylphorbol Acetate	39-42	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	89-98
8786321-5	1996	Mesangial cells preincubated with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, stimulated both the gene and protein expression of ICAM-1.	Tetradecanoylphorbol Acetate	34-65	intercellular adhesion molecule 1	Homo sapiens	160-166
8786321-5	1996	Mesangial cells preincubated with phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, stimulated both the gene and protein expression of ICAM-1.	Tetradecanoylphorbol Acetate	67-70	intercellular adhesion molecule 1	Homo sapiens	160-166
7306036-3	1981	In experiments designed to test this contention, it was found that addition of TPA (1 microM to 1 nM) to confluent mouse 3T3 fibroblasts successively caused the release of prostaglandins E2 and I2, induction of the enzyme ornithine decarboxylase (EC 4.1.1.17), stimulation of [3H]thymidine incorporation into DNA, and cell proliferation.	Tetradecanoylphorbol Acetate	79-82	ornithine decarboxylase, structural 1	Mus musculus	222-245
8689410-14	1996	When cells were simultaneously treated with 1 mumol/L PMA and ionomycin together for 1 hour, the increase in HSP-70 and HSF1 mRNAs reached a greater level than the level stimulated by either drug alone.	Tetradecanoylphorbol Acetate	54-57	heat shock protein family A (Hsp70) member 4	Homo sapiens	109-115
8689410-15	1996	CONCLUSIONS: These results indicate that both PMA and ionomycin stimulate HSF1, but not HSF2, translocation and synthesis leading to the HSP-70 expression and that their effects are Ca(2+)-dependent.	Tetradecanoylphorbol Acetate	46-49	heat shock protein family A (Hsp70) member 4	Homo sapiens	137-143
8621384-14	1996	Acute or chronic treatment with TGFalpha did not induce significant PKCdelta translocation in contrast to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, which induced both translocation and tyrosine phosphorylation of PKCdelta.	Tetradecanoylphorbol Acetate	124-160	protein kinase C, delta	Mus musculus	227-235
8608807-1	1996	Tumor necrosis factor (TNF), like granulocyte-macrophage colony-stimul ating factor (GM-CSF), rapidly primed human monocytes for enhanced release of superoxide (O-2) stimulated by receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A), but not by phorbol myristate acetate (PMA), which bypasses the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	294-319	immunoglobulin kappa variable 1D-39	Homo sapiens	161-164
21153286-10	1996	We concluded that stimulation of PKC by PMA appears to have inhibited the gonadotropin-induced increase in 3beta-HSD mRNA levels by preventing cAMP-activated 3beta-HSD-gene transcription.	Tetradecanoylphorbol Acetate	40-43	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	107-116
21153286-10	1996	We concluded that stimulation of PKC by PMA appears to have inhibited the gonadotropin-induced increase in 3beta-HSD mRNA levels by preventing cAMP-activated 3beta-HSD-gene transcription.	Tetradecanoylphorbol Acetate	40-43	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	158-167
8655638-5	1996	On the other hand, PMA-induced phosphorylation and translocation of p47phox were not affected by such a low dose of okadaic acid.	Tetradecanoylphorbol Acetate	19-22	neutrophil cytosolic factor 1	Homo sapiens	68-75
8608807-1	1996	Tumor necrosis factor (TNF), like granulocyte-macrophage colony-stimul ating factor (GM-CSF), rapidly primed human monocytes for enhanced release of superoxide (O-2) stimulated by receptor-mediated agonists, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and concanavalin A (Con A), but not by phorbol myristate acetate (PMA), which bypasses the receptors to stimulate the cells.	Tetradecanoylphorbol Acetate	321-324	immunoglobulin kappa variable 1D-39	Homo sapiens	161-164
7306036-7	1981	Pretreatment of the cells with 1,3-diaminopropane (1 mM) or alpha-methylornithine (5 mM), inhibitors of polyamine synthesis, decreased TPA-induced ornithine decarboxylase activity without affecting DNA synthesis.	Tetradecanoylphorbol Acetate	135-138	ornithine decarboxylase, structural 1	Mus musculus	147-170
7306036-8	1981	TPA stimulated [3H]thymidine incorporation into DNA, even when the ornithine decarboxylase activity was completely blocked.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	67-90
8599842-6	1996	The expression of TDAG8 is greatly induced upon activation of T cells by anti-TCR antibody or by phorbol 12-myristate 13-acetate plus ionomycin.	Tetradecanoylphorbol Acetate	97-128	G-protein coupled receptor 65	Mus musculus	18-23
8703375-4	1996	PMN incubated in the presence of the soluble stimuli phorbol myristate acetate(PMA, 100 ng/ml) or recombinant human C5a(rHC5a, 10(-8) M) generated significant amounts of hydrogen peroxide, increased their CD11b expression and decreased their CD16 expression.	Tetradecanoylphorbol Acetate	53-78	integrin subunit alpha M	Homo sapiens	205-210
6797751-1	1981	Topical administration of the promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), is accompanied by an increased incorporation of [3H]arachidonic acid into mouse skin and a very significant activation of epidermal cell membrane phospholipase A2 without affecting intracellular acid phospholipase.	Tetradecanoylphorbol Acetate	40-76	phospholipase A2, group IB, pancreas	Mus musculus	230-246
8703375-4	1996	PMN incubated in the presence of the soluble stimuli phorbol myristate acetate(PMA, 100 ng/ml) or recombinant human C5a(rHC5a, 10(-8) M) generated significant amounts of hydrogen peroxide, increased their CD11b expression and decreased their CD16 expression.	Tetradecanoylphorbol Acetate	53-78	Fc gamma receptor IIIa	Homo sapiens	242-246
8703375-4	1996	PMN incubated in the presence of the soluble stimuli phorbol myristate acetate(PMA, 100 ng/ml) or recombinant human C5a(rHC5a, 10(-8) M) generated significant amounts of hydrogen peroxide, increased their CD11b expression and decreased their CD16 expression.	Tetradecanoylphorbol Acetate	79-82	integrin subunit alpha M	Homo sapiens	205-210
8703375-4	1996	PMN incubated in the presence of the soluble stimuli phorbol myristate acetate(PMA, 100 ng/ml) or recombinant human C5a(rHC5a, 10(-8) M) generated significant amounts of hydrogen peroxide, increased their CD11b expression and decreased their CD16 expression.	Tetradecanoylphorbol Acetate	79-82	Fc gamma receptor IIIa	Homo sapiens	242-246
8645270-3	1996	However, when the agonist was concanavalin A (ConA) or phorbol 12-myristate 13-acetate (PMA), rac 1 and rac 2, but not the p190 GAP, were translocated.	Tetradecanoylphorbol Acetate	55-86	Rac family small GTPase 1	Homo sapiens	94-99
8645270-3	1996	However, when the agonist was concanavalin A (ConA) or phorbol 12-myristate 13-acetate (PMA), rac 1 and rac 2, but not the p190 GAP, were translocated.	Tetradecanoylphorbol Acetate	88-91	Rac family small GTPase 1	Homo sapiens	94-99
8631008-6	1996	Following exposure to 12-O-tetradecanoylphorbol-13-acetate, the FAS expression in HL60 cells is abolished, fatty acid synthesis diminishes, and the cells become insensitive to cerulenin while acquiring a differentiated, macrophage-like phenotype.	Tetradecanoylphorbol Acetate	22-58	fatty acid synthase	Homo sapiens	64-67
6797751-1	1981	Topical administration of the promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), is accompanied by an increased incorporation of [3H]arachidonic acid into mouse skin and a very significant activation of epidermal cell membrane phospholipase A2 without affecting intracellular acid phospholipase.	Tetradecanoylphorbol Acetate	78-81	phospholipase A2, group IB, pancreas	Mus musculus	230-246
7273334-7	1981	The relation between the rate of DNA-synthesis and the spermidine/spermine ratio as well as the ordered time sequence for the accumulation of putrescine and the induction of ODC and SAM-D activities, suggest a strong interdependence and a strict regulation of these events in hairless mouse epidermis induced to proliferate by TPA.	Tetradecanoylphorbol Acetate	327-330	ornithine decarboxylase, structural 1	Mus musculus	174-177
8660281-6	1996	In order to decide whether PKC is directly involved in the secretory process, the effect of down regulation of PKC by phorbol 12-myristate 13-acetate (PMA) was studied in primary cultured guinea pig parotid acinar cells.	Tetradecanoylphorbol Acetate	118-149	Prkca	Cavia porcellus	111-114
8660281-6	1996	In order to decide whether PKC is directly involved in the secretory process, the effect of down regulation of PKC by phorbol 12-myristate 13-acetate (PMA) was studied in primary cultured guinea pig parotid acinar cells.	Tetradecanoylphorbol Acetate	151-154	Prkca	Cavia porcellus	111-114
8621697-0	1996	Activation of epidermal growth factor receptor gene transcription by phorbol 12-myristate 13-acetate is mediated by activator protein 2.	Tetradecanoylphorbol Acetate	69-100	transcription factor AP-2 alpha	Homo sapiens	116-135
8866753-4	1996	Acteoside prevented the up-regulation of ICAM-1 expression mediated by inflammatory cytokines or phorbol 12-myristate 13-acetate on HUVECs and rat mesangial cells.	Tetradecanoylphorbol Acetate	97-128	intercellular adhesion molecule 1	Rattus norvegicus	41-47
8750931-1	1996	Although the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA) has been known to induce heterologous desensitization of the epidermal adenylate cyclase, the precise mechanism of PMA action remains unknown.	Tetradecanoylphorbol Acetate	47-78	protein kinase C, gamma	Rattus norvegicus	13-29
8750931-1	1996	Although the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA) has been known to induce heterologous desensitization of the epidermal adenylate cyclase, the precise mechanism of PMA action remains unknown.	Tetradecanoylphorbol Acetate	47-78	protein kinase C, gamma	Rattus norvegicus	31-34
7328673-8	1981	ODC induction after exposure to 12-0-tetradecanoylphorbol-13-acetate (TPA) in basal cells is enhanced 20-fold over the response of a culture population containing both differentiating and basal cells.	Tetradecanoylphorbol Acetate	70-73	ornithine decarboxylase, structural 1	Mus musculus	0-3
8750931-1	1996	Although the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA) has been known to induce heterologous desensitization of the epidermal adenylate cyclase, the precise mechanism of PMA action remains unknown.	Tetradecanoylphorbol Acetate	80-83	protein kinase C, gamma	Rattus norvegicus	13-29
8750931-1	1996	Although the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA) has been known to induce heterologous desensitization of the epidermal adenylate cyclase, the precise mechanism of PMA action remains unknown.	Tetradecanoylphorbol Acetate	80-83	protein kinase C, gamma	Rattus norvegicus	31-34
8603426-1	1996	CD4+ T cells from mice with murine AIDS (MAIDS) have been shown to be unable to respond to TCR stimulation as measured by proliferation, IL-2 production, or IL-2R upregulation, although responsiveness was restored with PMA and ionomycin.	Tetradecanoylphorbol Acetate	219-222	CD4 antigen	Mus musculus	0-3
8603430-0	1996	Cellular induction mechanism of CD8+ suppressor T cells by DMBA and TPA: formation of CD4+ suppressor-inducer T cells.	Tetradecanoylphorbol Acetate	68-71	CD4 antigen	Mus musculus	86-89
7328673-11	1981	After exposure to low concentrations of TPA or to weak promoters of the phorbol ester series, ODC activity is maximal at 3 hr.	Tetradecanoylphorbol Acetate	40-43	ornithine decarboxylase, structural 1	Mus musculus	94-97
8603430-3	1996	And the macrophages plus TPA induced CD4+ T suppressor inducer cells in the mice spleens.	Tetradecanoylphorbol Acetate	25-28	CD4 antigen	Mus musculus	37-40
8825424-3	1996	Matrix metalloproteinase-9 activity was induced by phorbol 12-myristate 13-acetate (apical), interleukin-1 alpha (basal), and by conditioned medium from DX3 human melanoma cells (basal).	Tetradecanoylphorbol Acetate	51-82	matrix metallopeptidase 9	Homo sapiens	0-26
7328673-12	1981	With higher concentrations of TPA, the ODC maximum is at 9 hr.	Tetradecanoylphorbol Acetate	30-33	ornithine decarboxylase, structural 1	Mus musculus	39-42
6116315-7	1981	Following the administration of epidermal extracts, the inhibition of the TPA-induced ODC-response correlated positively with the presence of epidermal G2-chalone activity (determined by a stathmokinetic method) whereas myocardial, skeletal muscle, or heat-inactivated epidermal extracts with no epidermal G2-chalone activity, had no effect on TPA-induced ODC activity.	Tetradecanoylphorbol Acetate	344-347	ornithine decarboxylase, structural 1	Mus musculus	86-89
8530360-6	1995	Phorbol 12-myristate 13-acetate did not activate the JNKs although it activated ERK1 and ERK2, which phosphorylated the c-Jun transactivation domain in vitro.	Tetradecanoylphorbol Acetate	0-31	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-125
8730514-5	1996	Downregulation of PKC alpha and PKC epsilon isoforms following chronic phorbol myristate 12, 13-acetate (PMA) pre-treatment resulted in the abolition of AII-stimulated MAP kinase activation.	Tetradecanoylphorbol Acetate	105-108	protein kinase C, alpha	Rattus norvegicus	18-27
21153293-6	1996	TPA, an activator of protein kinase C, enhanced p21( ras ) and MAP-kinase activity in Nb2-11C cells but failed to induce proliferation.	Tetradecanoylphorbol Acetate	0-3	KRAS proto-oncogene, GTPase	Rattus norvegicus	48-51
7471050-6	1980	Mixing of soluble extracts from TPA-treated mouse epidermis posttreated either with acetone or putrescine or with mouse epidermis treated with putrescine alone gave essentially additive ODC activity.	Tetradecanoylphorbol Acetate	32-35	ornithine decarboxylase, structural 1	Mus musculus	186-189
7388798-4	1980	5,6-Epoxyretinoic acid, 5,6-dihydroretinoic acid, and retinoic acid were equally effective in inhibiting the induction of ODC activity by TPA.	Tetradecanoylphorbol Acetate	138-141	ornithine decarboxylase, structural 1	Mus musculus	122-125
8727695-1	1996	How 4 beta-phorbol 12-myristate 13-acetate (PMA) and ionomycin (Io), a calcium ionophore, affect on the atrial natriuretic peptide (ANP) stimulated cyclic-3",5"-guanosine monophosphate (cGMP) production in cultured rat mesangial cells was examined.	Tetradecanoylphorbol Acetate	6-42	natriuretic peptide A	Rattus norvegicus	104-130
8727695-1	1996	How 4 beta-phorbol 12-myristate 13-acetate (PMA) and ionomycin (Io), a calcium ionophore, affect on the atrial natriuretic peptide (ANP) stimulated cyclic-3",5"-guanosine monophosphate (cGMP) production in cultured rat mesangial cells was examined.	Tetradecanoylphorbol Acetate	44-47	natriuretic peptide A	Rattus norvegicus	104-130
7588323-8	1995	Although AII and TPA (known activators of protein kinase C) as well as forskolin and (Bu)2cAMP (known activators of protein kinase A) increased the expression of 3 beta HSD mRNA, K+ treatment was without effect, suggesting that elevation of [Ca2+]i in response to K+ did not activate the protein kinase C or protein kinase A signaling pathways.	Tetradecanoylphorbol Acetate	17-20	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	162-172
7499370-2	1995	The tyrosine kinase inhibitor herbimycin A was found to block NF-kappa B stimulation in response to interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat T lymphoma cells.	Tetradecanoylphorbol Acetate	118-149	epilepsy 4	Mus musculus	153-156
7388798-6	1980	These results indicate that (a) epoxidation of retinoic acid at the 5,6-position is not a rate-limiting modification for the anti-promoting activity of retinoic acid and that (b) inhibition of the induction by TPA of mouse epidermal ODC activity may be a simple test for screening the potential prophylactic activities of new retinoids.	Tetradecanoylphorbol Acetate	210-213	ornithine decarboxylase, structural 1	Mus musculus	233-236
6967217-10	1980	Terminal transferase activities and percentages of terminal-transferase-positive cells in these cultures were reduced to as low as 1/10th in 4 days in the presence of 16 nM TPA.	Tetradecanoylphorbol Acetate	173-176	DNA nucleotidylexotransferase	Homo sapiens	0-20
8675753-5	1995	Parathyroid hormone treatment significantly enhanced (threefold) release of superoxide anion by monocytes stimulated with phorbol 12-myristate 13-acetate and increased migration of monocytes to bone particles in vitro.	Tetradecanoylphorbol Acetate	122-153	parathyroid hormone	Bos taurus	0-19
8632663-4	1995	Consistent with these findings, MC3 cells treated with TPA showed an increased expression of GATA-1, but not GATA-3 transcripts, whereas those without TPA treatment expressed only the GATA-2 transcript.	Tetradecanoylphorbol Acetate	55-58	GATA binding protein 3	Homo sapiens	109-115
8555236-8	1996	Furthermore, DMS inhibited the release of Sph-1-P from platelets stimulated with 12-O-tetradecanoylphorbol 13-acetate and inhibited platelet aggregation induced by exogenous addition of Sph-1-P.	Tetradecanoylphorbol Acetate	81-117	ankyrin 1	Homo sapiens	42-47
8564924-6	1996	(2) All-trans beta-carotene caused a remarkable stimulation for the early induction of ornithine decarboxylase (ODC) activity after the stimulation of TPA and fetal bovine serum.	Tetradecanoylphorbol Acetate	151-154	ornithine decarboxylase, structural 1	Mus musculus	112-115
8558059-5	1996	The PMA-induced translocation of p47phox to the plasma membrane was diminished in neutrophils loaded with peptide 4.	Tetradecanoylphorbol Acetate	4-7	neutrophil cytosolic factor 1	Homo sapiens	33-40
6967217-10	1980	Terminal transferase activities and percentages of terminal-transferase-positive cells in these cultures were reduced to as low as 1/10th in 4 days in the presence of 16 nM TPA.	Tetradecanoylphorbol Acetate	173-176	DNA nucleotidylexotransferase	Homo sapiens	51-71
315310-2	1979	We report here that even short exposure of lymphocytes to 12-O-tetradecanoyl-phorbol 13-acetate changes the balance between the levels of neutral ribonuclease and ribonuclease inhibitor.	Tetradecanoylphorbol Acetate	58-95	ribonuclease/angiogenin inhibitor 1	Homo sapiens	163-185
8624460-5	1996	In this review, a novel posttranscriptional regulation of ICAM-1 gene expression by two inflammatory mediators, interferon-gamma and phorbol myristate acetate, and the possible role of the serine/threonine phosphorylation pathway in the cycloheximide-induced ICAM-1 message stabilization are discussed in light of our current understanding of ICAM-1 gene regulation during an inflammatory response.	Tetradecanoylphorbol Acetate	133-158	intercellular adhesion molecule 1	Homo sapiens	58-64
8624460-5	1996	In this review, a novel posttranscriptional regulation of ICAM-1 gene expression by two inflammatory mediators, interferon-gamma and phorbol myristate acetate, and the possible role of the serine/threonine phosphorylation pathway in the cycloheximide-induced ICAM-1 message stabilization are discussed in light of our current understanding of ICAM-1 gene regulation during an inflammatory response.	Tetradecanoylphorbol Acetate	133-158	intercellular adhesion molecule 1	Homo sapiens	259-265
8624460-5	1996	In this review, a novel posttranscriptional regulation of ICAM-1 gene expression by two inflammatory mediators, interferon-gamma and phorbol myristate acetate, and the possible role of the serine/threonine phosphorylation pathway in the cycloheximide-induced ICAM-1 message stabilization are discussed in light of our current understanding of ICAM-1 gene regulation during an inflammatory response.	Tetradecanoylphorbol Acetate	133-158	intercellular adhesion molecule 1	Homo sapiens	259-265
7478524-7	1995	Among UT16 cells, most of TPA-inducible PTPase genes, PTP-1C, PTP-MEG2, P19-PTP, HPTP epsilon, and PTP-U1, did not respond to TPA.	Tetradecanoylphorbol Acetate	26-29	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	54-60
7498491-0	1995	The recombinant GABA transporter GAT1 is downregulated upon activation of protein kinase C. Treatment of human embryonic kidney 293 cells expressing the rat gamma-aminobutyric acid (GABA) transporter 1 (GAT1) with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) was found to decrease the velocity of specific [3H]GABA uptake.	Tetradecanoylphorbol Acetate	251-282	solute carrier family 6 member 12	Rattus norvegicus	157-201
8838143-3	1996	Treatment of cells with TPA increased c-fos mRNA 20-fold with only a 2-fold increase in c-jun mRNA levels.	Tetradecanoylphorbol Acetate	24-27	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	38-43
315310-5	1979	Both 12-O-tetradecanoyl-phorbol 13-acetate and phytohaemagglutinin increase the level of ribonuclease inhibitor in T cells.	Tetradecanoylphorbol Acetate	5-42	ribonuclease/angiogenin inhibitor 1	Homo sapiens	89-111
8710683-3	1996	Cell-conditioned media (CM) from EL-4 cells treated with 0.2 ng/ml phorbol myristate acetate (PMA) + 0.1 microgram/ml VES contained increased amounts of IL-2, as determined by the murine cytotoxic T cell IL-2-dependent CTLL-2 bioassay.	Tetradecanoylphorbol Acetate	67-92	epilepsy 4	Mus musculus	33-37
7498491-0	1995	The recombinant GABA transporter GAT1 is downregulated upon activation of protein kinase C. Treatment of human embryonic kidney 293 cells expressing the rat gamma-aminobutyric acid (GABA) transporter 1 (GAT1) with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) was found to decrease the velocity of specific [3H]GABA uptake.	Tetradecanoylphorbol Acetate	251-282	solute carrier family 6 member 12	Rattus norvegicus	203-207
7498491-0	1995	The recombinant GABA transporter GAT1 is downregulated upon activation of protein kinase C. Treatment of human embryonic kidney 293 cells expressing the rat gamma-aminobutyric acid (GABA) transporter 1 (GAT1) with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) was found to decrease the velocity of specific [3H]GABA uptake.	Tetradecanoylphorbol Acetate	284-287	solute carrier family 6 member 12	Rattus norvegicus	157-201
7498491-0	1995	The recombinant GABA transporter GAT1 is downregulated upon activation of protein kinase C. Treatment of human embryonic kidney 293 cells expressing the rat gamma-aminobutyric acid (GABA) transporter 1 (GAT1) with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) was found to decrease the velocity of specific [3H]GABA uptake.	Tetradecanoylphorbol Acetate	284-287	solute carrier family 6 member 12	Rattus norvegicus	203-207
8710683-3	1996	Cell-conditioned media (CM) from EL-4 cells treated with 0.2 ng/ml phorbol myristate acetate (PMA) + 0.1 microgram/ml VES contained increased amounts of IL-2, as determined by the murine cytotoxic T cell IL-2-dependent CTLL-2 bioassay.	Tetradecanoylphorbol Acetate	94-97	epilepsy 4	Mus musculus	33-37
454439-0	1979	Reduction and subsequent oxidation of a cytochrome b of human neutrophils after stimulation with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	97-122	mitochondrially encoded cytochrome b	Homo sapiens	40-52
7594530-8	1995	To determine whether TAPI would prevent shedding under more physiologic conditions, we demonstrated that TAPI was able to prevent unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes.	Tetradecanoylphorbol Acetate	147-150	sequestosome 1	Homo sapiens	202-205
8632663-3	1995	TPA treatment also enhanced the expression of GPIIb mRNA, and induced the expression of interleukin-6 (IL-6) and its receptor mRNAs, while it did not induce transcripts of the genes IL-11 and mpl ligand, and further decreased the transcript of the mpl gene.	Tetradecanoylphorbol Acetate	0-3	integrin subunit alpha 2b	Homo sapiens	46-51
8750893-3	1995	SgII mRNA levels remained elevated for 24 h. Activation of protein kinase C with 100 nM phorbol 12-myristate 13-acetate (PMA) also increased SgII mRNA expression, although induction with PMA was slower and more moderate (3.8-fold above control after 24 h).	Tetradecanoylphorbol Acetate	88-119	secretogranin II	Rattus norvegicus	0-4
7592995-2	1995	In this work, we demonstrate that the levels of c-jun mRNA, c-Jun protein, and DNA binding activity of a nuclear transcription factor AP-1 to 12-o-tetradecanoylphorbol 13-acetate responsive elements all increased following treatment with the cell-permeable ceramide, N-acetylsphingosine in human leukemia HL-60 cells.	Tetradecanoylphorbol Acetate	142-178	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	48-53
7592995-2	1995	In this work, we demonstrate that the levels of c-jun mRNA, c-Jun protein, and DNA binding activity of a nuclear transcription factor AP-1 to 12-o-tetradecanoylphorbol 13-acetate responsive elements all increased following treatment with the cell-permeable ceramide, N-acetylsphingosine in human leukemia HL-60 cells.	Tetradecanoylphorbol Acetate	142-178	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-138
7592861-5	1995	TPA-dependent stimulation can also be demonstrated by co-transfection with plasmid DNAs that overexpress the JUN family of proteins, especially c-JUN.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	144-149
7592895-1	1995	We have recently shown that addition of follitropin (FSH) or a phorbol ester (phorbol 12-myristate 13-acetate (PMA)) to cells expressing the recombinant follitropin receptor (FSHR) results in both phosphorylation and uncoupling of the FSHR from adenylyl cyclase.	Tetradecanoylphorbol Acetate	78-109	follicle stimulating hormone receptor	Homo sapiens	153-173
8750893-3	1995	SgII mRNA levels remained elevated for 24 h. Activation of protein kinase C with 100 nM phorbol 12-myristate 13-acetate (PMA) also increased SgII mRNA expression, although induction with PMA was slower and more moderate (3.8-fold above control after 24 h).	Tetradecanoylphorbol Acetate	88-119	secretogranin II	Rattus norvegicus	141-145
8750893-3	1995	SgII mRNA levels remained elevated for 24 h. Activation of protein kinase C with 100 nM phorbol 12-myristate 13-acetate (PMA) also increased SgII mRNA expression, although induction with PMA was slower and more moderate (3.8-fold above control after 24 h).	Tetradecanoylphorbol Acetate	121-124	secretogranin II	Rattus norvegicus	0-4
8750893-3	1995	SgII mRNA levels remained elevated for 24 h. Activation of protein kinase C with 100 nM phorbol 12-myristate 13-acetate (PMA) also increased SgII mRNA expression, although induction with PMA was slower and more moderate (3.8-fold above control after 24 h).	Tetradecanoylphorbol Acetate	121-124	secretogranin II	Rattus norvegicus	141-145
28370-4	1978	These studies show that TPA tyrosinase is kinetically normal and that the defect with this form of albinism must be elsewhere in the melanin pathway.	Tetradecanoylphorbol Acetate	24-27	tyrosinase	Homo sapiens	28-38
7593412-7	1995	A PKC activator, 12-O-tetradecanoylphorbol 13-acetate, also decreased PAF-AH secretion.	Tetradecanoylphorbol Acetate	17-53	phospholipase A2 group VII	Homo sapiens	70-76
7592895-1	1995	We have recently shown that addition of follitropin (FSH) or a phorbol ester (phorbol 12-myristate 13-acetate (PMA)) to cells expressing the recombinant follitropin receptor (FSHR) results in both phosphorylation and uncoupling of the FSHR from adenylyl cyclase.	Tetradecanoylphorbol Acetate	78-109	follicle stimulating hormone receptor	Homo sapiens	175-179
7592895-1	1995	We have recently shown that addition of follitropin (FSH) or a phorbol ester (phorbol 12-myristate 13-acetate (PMA)) to cells expressing the recombinant follitropin receptor (FSHR) results in both phosphorylation and uncoupling of the FSHR from adenylyl cyclase.	Tetradecanoylphorbol Acetate	78-109	follicle stimulating hormone receptor	Homo sapiens	235-239
7592895-1	1995	We have recently shown that addition of follitropin (FSH) or a phorbol ester (phorbol 12-myristate 13-acetate (PMA)) to cells expressing the recombinant follitropin receptor (FSHR) results in both phosphorylation and uncoupling of the FSHR from adenylyl cyclase.	Tetradecanoylphorbol Acetate	111-114	follicle stimulating hormone receptor	Homo sapiens	153-173
7592895-1	1995	We have recently shown that addition of follitropin (FSH) or a phorbol ester (phorbol 12-myristate 13-acetate (PMA)) to cells expressing the recombinant follitropin receptor (FSHR) results in both phosphorylation and uncoupling of the FSHR from adenylyl cyclase.	Tetradecanoylphorbol Acetate	111-114	follicle stimulating hormone receptor	Homo sapiens	175-179
7592895-1	1995	We have recently shown that addition of follitropin (FSH) or a phorbol ester (phorbol 12-myristate 13-acetate (PMA)) to cells expressing the recombinant follitropin receptor (FSHR) results in both phosphorylation and uncoupling of the FSHR from adenylyl cyclase.	Tetradecanoylphorbol Acetate	111-114	follicle stimulating hormone receptor	Homo sapiens	235-239
269443-6	1977	Paradoxially, FA potentiates the increase in ornithine decarboxylase activity after TPA administeration both in vivo and in vitro.	Tetradecanoylphorbol Acetate	84-87	ornithine decarboxylase, structural 1	Mus musculus	45-68
8593248-4	1995	Here we investigate the effect of well-known PKC activator 12-O-tetradecanoyl-2 phorbol-13-acetate (TPA), on the levels of 32P incorporation into EGF induced phosphatidylinositols (PI, PI4P, PI4, 5P2) and different phospholipids (PC, PA, PS) as well as on induced tyrosine kinase activity.	Tetradecanoylphorbol Acetate	100-103	serpin family A member 4	Homo sapiens	185-199
7559616-2	1995	However, while TPA, as expected, powerfully stimulated the phosphorylation of the PKCs" 85-kDa myristoylated alanine-rich protein kinase C substrate (MARCKS) protein, ionomycin unexpectedly did not.	Tetradecanoylphorbol Acetate	15-18	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	95-148
7559616-2	1995	However, while TPA, as expected, powerfully stimulated the phosphorylation of the PKCs" 85-kDa myristoylated alanine-rich protein kinase C substrate (MARCKS) protein, ionomycin unexpectedly did not.	Tetradecanoylphorbol Acetate	15-18	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	150-156
7559616-4	1995	Pretreating the glioma cells with ionomycin prevented TPA-stimulated PKCs from phosphorylating the MARCKS protein.	Tetradecanoylphorbol Acetate	54-57	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	99-105
8589457-6	1995	Rather, the induction of glucose transport in chicken embryo fibroblasts by v-src, serum, and 12-O-tetradecanoylphorbol 13-acetate was associated with induction of GLUT3 mRNA level and GLUT3 transcription.	Tetradecanoylphorbol Acetate	94-130	solute carrier family 2 member 14	Gallus gallus	164-169
8589457-6	1995	Rather, the induction of glucose transport in chicken embryo fibroblasts by v-src, serum, and 12-O-tetradecanoylphorbol 13-acetate was associated with induction of GLUT3 mRNA level and GLUT3 transcription.	Tetradecanoylphorbol Acetate	94-130	solute carrier family 2 member 14	Gallus gallus	185-190
7592779-1	1995	Stimulation of NIH 3T3 cells with platelet-derived growth factor (PDGF)-BB and 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances vascular endothelial growth factor (VEGF) gene expression.	Tetradecanoylphorbol Acetate	117-120	vascular endothelial growth factor A	Mus musculus	167-171
7592779-2	1995	To address the question of whether Ras and Raf are involved in the induction of VEGF gene expression by PDGF and TPA, we examined the effects of both factors on NIH 3T3 cells stably transfected with v-Ha-ras or v-raf.	Tetradecanoylphorbol Acetate	113-116	vascular endothelial growth factor A	Mus musculus	80-84
7592779-4	1995	Stimulation with PDGF or TPA resulted in increased VEGF mRNA in all cell lines, with highest levels found in the transformed cells.	Tetradecanoylphorbol Acetate	25-28	vascular endothelial growth factor A	Mus musculus	51-55
7559616-9	1995	In the present experiments calmodulin prevented MARCKS phosphorylation by TPA-stimulated PKCs in glioma cell lysates, and this blockade was lifted by a calmodulin antagonist, the calmodulin-binding domain peptide.	Tetradecanoylphorbol Acetate	74-77	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	48-54
861945-0	1977	Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.	Tetradecanoylphorbol Acetate	54-91	ornithine decarboxylase, structural 1	Mus musculus	100-123
7559616-12	1995	The ability of ionomycin to prevent TPA-stimulated PKCs from phosphorylating MARCKS depended on whether ionomycin was added before, with, or after TPA.	Tetradecanoylphorbol Acetate	36-39	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	77-83
7594621-3	1995	Separated neutrophils are also more resistant than unseparated neutrophils to PMA induced upregulation of a functional epitope of CD11b.	Tetradecanoylphorbol Acetate	78-81	integrin subunit alpha M	Homo sapiens	130-135
7586169-11	1995	Western blot analyses of TPA-treated WB-F344 or C10 cells revealed the presence of a hyperphosphorylated form of Cx43 (Cx43-P3) and no reduction in Cx43-P2, in contrast to BHT-treated cells.	Tetradecanoylphorbol Acetate	25-28	gene rich cluster, C10 gene	Mus musculus	48-51
8528190-5	1995	Phorbol myristate acetate can cause an increase, at 4 and 8 hours of differentiation, of intracellular levels of putrescine as well as a decrease in terminal deoxynucleotidyl transferase synthesis showing the probable involvement that polyamines have in the differentiation process.	Tetradecanoylphorbol Acetate	0-25	DNA nucleotidylexotransferase	Homo sapiens	149-186
191821-0	1977	Dissociation of increases in levels of 3":5"-cyclic AMP and 3":5"-cyclic GMP from induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate in mouse epidermis in vivo.	Tetradecanoylphorbol Acetate	141-178	ornithine decarboxylase, structural 1	Mus musculus	95-118
7664646-4	1995	In this culture system, 10(-10)-10(-8) M 12-O-tetradecanoylphorbol-13-acetate stimulated the formation of TRAP-positive MNCs, whereas salmon calcitonin inhibited it.	Tetradecanoylphorbol Acetate	41-77	acid phosphatase 5, tartrate resistant	Mus musculus	106-110
7545901-1	1995	Experiments were carried out to determine Raf-1 protein kinase domain fragments which exhibit a characteristic electrophoretic mobility shift noted with Raf-1 protein kinase in response to serum and phorbol ester (PMA) treatment of serum-deprived NIH 3T3 cells.	Tetradecanoylphorbol Acetate	214-217	v-raf-leukemia viral oncogene 1	Mus musculus	42-47
7548231-6	1995	We show that clusterin gene expression is repressed in cells undergoing apoptosis in response to the application of RU 486 and TPA, but is unchanged in cells in which apoptosis has been triggered by cholesterol treatment.	Tetradecanoylphorbol Acetate	127-130	clusterin	Canis lupus familiaris	13-22
191821-1	1977	A single application of 17 nmol of 12-O-tetradecanoyl phorbol-13-acetate (TPA) to mouse skin caused a marked (200- to 400-fold) induction of ornithine decarboxylase (EC 4.1.1.17, L-ornithine carboxy-lyase) activity in mouse epidermal and epidermal-dermal preparations.	Tetradecanoylphorbol Acetate	35-72	ornithine decarboxylase, structural 1	Mus musculus	141-164
7557381-4	1995	A second tyrosine kinase activity is induced in response to both calcium and TPA, and has been identified as fyn, a nonreceptor tyrosine kinase of the src family.	Tetradecanoylphorbol Acetate	77-80	Fyn proto-oncogene	Mus musculus	109-112
7545901-1	1995	Experiments were carried out to determine Raf-1 protein kinase domain fragments which exhibit a characteristic electrophoretic mobility shift noted with Raf-1 protein kinase in response to serum and phorbol ester (PMA) treatment of serum-deprived NIH 3T3 cells.	Tetradecanoylphorbol Acetate	214-217	v-raf-leukemia viral oncogene 1	Mus musculus	153-158
7545901-5	1995	These results suggest that modification(s) within the 33 kDa C-terminal portion of Raf-1 which occur independently of association with Ras may be responsible for the band shift observed with serum and PMA treatment of serum-deprived NIH 3T3 cells.	Tetradecanoylphorbol Acetate	201-204	v-raf-leukemia viral oncogene 1	Mus musculus	83-88
7557381-5	1995	fyn activation is induced in keratinocytes within 6 hr of calcium exposure, but already within 2 min of TPA treatment.	Tetradecanoylphorbol Acetate	104-107	Fyn proto-oncogene	Mus musculus	0-3
191821-1	1977	A single application of 17 nmol of 12-O-tetradecanoyl phorbol-13-acetate (TPA) to mouse skin caused a marked (200- to 400-fold) induction of ornithine decarboxylase (EC 4.1.1.17, L-ornithine carboxy-lyase) activity in mouse epidermal and epidermal-dermal preparations.	Tetradecanoylphorbol Acetate	74-77	ornithine decarboxylase, structural 1	Mus musculus	141-164
7557381-6	1995	Cortactin, a p80-85 substrate of src- and fyn-related kinases that localizes with actin at cell adhesion sites, is increasingly tyrosine phosphorylated in calcium- and TPA-induced differentiation, with a time course which parallels that of fyn activation.	Tetradecanoylphorbol Acetate	168-171	Fyn proto-oncogene	Mus musculus	42-45
191821-5	1977	When isoproterenol was injected 10 min prior to an application of either 1.7 or 17 nmol of TPA, the magnitude of the ornithine decarboxylase induction was the same as induction with TPA alone.	Tetradecanoylphorbol Acetate	91-94	ornithine decarboxylase, structural 1	Mus musculus	117-140
7557381-6	1995	Cortactin, a p80-85 substrate of src- and fyn-related kinases that localizes with actin at cell adhesion sites, is increasingly tyrosine phosphorylated in calcium- and TPA-induced differentiation, with a time course which parallels that of fyn activation.	Tetradecanoylphorbol Acetate	168-171	Fyn proto-oncogene	Mus musculus	240-243
8552303-4	1995	The potent PKC activator, 12-O-tetradecanoyl phorbol 13-acetate (TPA), also stimulated RCEC proliferation, whereas the inhibition of PKC by staurosporine caused a concomitant loss in ACM-induced PKC translocation, MARCKS protein phosphorylation and DNA synthesis.	Tetradecanoylphorbol Acetate	26-63	protein kinase C, gamma	Rattus norvegicus	11-14
8552303-4	1995	The potent PKC activator, 12-O-tetradecanoyl phorbol 13-acetate (TPA), also stimulated RCEC proliferation, whereas the inhibition of PKC by staurosporine caused a concomitant loss in ACM-induced PKC translocation, MARCKS protein phosphorylation and DNA synthesis.	Tetradecanoylphorbol Acetate	65-68	protein kinase C, gamma	Rattus norvegicus	11-14
8552303-4	1995	The potent PKC activator, 12-O-tetradecanoyl phorbol 13-acetate (TPA), also stimulated RCEC proliferation, whereas the inhibition of PKC by staurosporine caused a concomitant loss in ACM-induced PKC translocation, MARCKS protein phosphorylation and DNA synthesis.	Tetradecanoylphorbol Acetate	65-68	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	214-220
34054535-5	2021	The PKC gene of H9C2 was knocked down by siRNA and overexpressed by phorbol 12-myristate 13-acetate (PMA, PKC agonist).	Tetradecanoylphorbol Acetate	68-99	protein kinase C, gamma	Rattus norvegicus	4-7
7664289-10	1995	Although STR-3 could be induced in normal pulmonary fibroblasts with growth factors (basic fibroblast growth factor and platelet-derived growth factor) and/or 12-O-tetradecanoylphorbol-13-acetate, STR-3 induction was inhibited by all-trans retinoic acid, a commonly used chemopreventive agent for aerodigestive tract malignancies.	Tetradecanoylphorbol Acetate	159-195	matrix metallopeptidase 11	Homo sapiens	9-14
7548173-5	1995	RBL-2H3 cells express PKC alpha, beta, delta, epsilon and zeta isozymes and down-regulation of PKC by exposure to PMA (20 nM) for 1-2 h caused rapid decrease in PKC alpha and beta isozymes, leaving PKC delta, epsilon and zeta isozymes intact.	Tetradecanoylphorbol Acetate	114-117	protein kinase C, alpha	Rattus norvegicus	22-31
7548173-5	1995	RBL-2H3 cells express PKC alpha, beta, delta, epsilon and zeta isozymes and down-regulation of PKC by exposure to PMA (20 nM) for 1-2 h caused rapid decrease in PKC alpha and beta isozymes, leaving PKC delta, epsilon and zeta isozymes intact.	Tetradecanoylphorbol Acetate	114-117	protein kinase C, alpha	Rattus norvegicus	22-25
7548173-5	1995	RBL-2H3 cells express PKC alpha, beta, delta, epsilon and zeta isozymes and down-regulation of PKC by exposure to PMA (20 nM) for 1-2 h caused rapid decrease in PKC alpha and beta isozymes, leaving PKC delta, epsilon and zeta isozymes intact.	Tetradecanoylphorbol Acetate	114-117	protein kinase C, alpha	Rattus norvegicus	161-170
7548173-6	1995	Apparent decreases in the levels of PKC alpha and beta to about 50% were observed after adding 20 nM PMA for 1 h, when PMA-stimulated PLD activity was inhibited by up to 70%.	Tetradecanoylphorbol Acetate	101-104	protein kinase C, alpha	Rattus norvegicus	36-45
7554075-6	1995	TPA- and mirex-promoted papillomas that were refractory to RA and FA demonstrated the same incidence of Ha-ras mutation as TPA- or mirex-promoted papillomas without RA and FA treatment, further indicating that the inhibitory activity of RA and FA is promoter-dependent and not solely dependent on mutant Ha-ras.	Tetradecanoylphorbol Acetate	0-3	Harvey rat sarcoma virus oncogene	Mus musculus	104-110
7554075-6	1995	TPA- and mirex-promoted papillomas that were refractory to RA and FA demonstrated the same incidence of Ha-ras mutation as TPA- or mirex-promoted papillomas without RA and FA treatment, further indicating that the inhibitory activity of RA and FA is promoter-dependent and not solely dependent on mutant Ha-ras.	Tetradecanoylphorbol Acetate	0-3	Harvey rat sarcoma virus oncogene	Mus musculus	304-310
7548173-6	1995	Apparent decreases in the levels of PKC alpha and beta to about 50% were observed after adding 20 nM PMA for 1 h, when PMA-stimulated PLD activity was inhibited by up to 70%.	Tetradecanoylphorbol Acetate	119-122	protein kinase C, alpha	Rattus norvegicus	36-45
7585834-10	1995	Phorbol 12-myristate 13-acetate also decreased [Ca2+]i transients, caused c-fos induction, and provoked hypertrophy in myocytes.	Tetradecanoylphorbol Acetate	0-31	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-79
34054535-5	2021	The PKC gene of H9C2 was knocked down by siRNA and overexpressed by phorbol 12-myristate 13-acetate (PMA, PKC agonist).	Tetradecanoylphorbol Acetate	68-99	protein kinase C, gamma	Rattus norvegicus	106-109
7585834-14	1995	Phorbol 12-myristate 13-acetate did not affect [Ca2+]i or cellular growth in nonmyocytes but did cause c-fos induction.	Tetradecanoylphorbol Acetate	0-31	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	103-108
34054535-5	2021	The PKC gene of H9C2 was knocked down by siRNA and overexpressed by phorbol 12-myristate 13-acetate (PMA, PKC agonist).	Tetradecanoylphorbol Acetate	101-104	protein kinase C, gamma	Rattus norvegicus	4-7
33044016-10	2021	Additionally, overexpression of miR-1696 can not only inhibit the formation of NETs by restraining the expression of GPx3, interfering with the generation of ROS and activation of the MAPK and PI3K/AKT pathways, but also reducing the release of PMA-induced NETs promoted by overexpression of GPx3.	Tetradecanoylphorbol Acetate	245-248	microRNA 1696	Gallus gallus	32-40
8519690-8	1995	Either 12 or 24 h treatment with 200 or 2000 ng/ml TPA caused complete PKC alpha and partial PKC delta down-regulation in C3, T5, and NRK cells.	Tetradecanoylphorbol Acetate	51-54	protein kinase C, delta	Mus musculus	93-102
8519690-13	1995	Both aFGF and basic FGF (bFGF) promoted concentration-dependent enhancement of TPA-pretreated T5 cell thymidine incorporation, and the effects of combined TPA and either aFGF or bFGF treatment were additive.	Tetradecanoylphorbol Acetate	79-82	fibroblast growth factor 1	Rattus norvegicus	5-9
7590880-5	1995	Activation of B cells [phorbol myristate acetate (PMA), surface immunoglobulin cross-linking alone or in the presence of interleukin-2 (IL-2)] induced CD44E (variable exon V8-10), R2 (VIO) and CD44 isoforms containing exons V6 and/or V7 (CD44 V6/V7).	Tetradecanoylphorbol Acetate	23-48	CD44 molecule (Indian blood group)	Homo sapiens	151-155
7649107-3	1995	In the current report we established the mechanisms of the PKC-activating phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) and the steroid hormone E2 on the induction of AR expression in human breast carcinoma cell lines.	Tetradecanoylphorbol Acetate	104-140	amphiregulin	Homo sapiens	194-196
7649107-3	1995	In the current report we established the mechanisms of the PKC-activating phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) and the steroid hormone E2 on the induction of AR expression in human breast carcinoma cell lines.	Tetradecanoylphorbol Acetate	142-145	amphiregulin	Homo sapiens	194-196
7649107-4	1995	TPA (100 nM) and E2 (1 nM) induce AR messenger RNA (mRNA) expression by 6- to 8-fold and 3- to 6-fold, respectively, in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	0-3	amphiregulin	Homo sapiens	34-36
7649107-5	1995	In addition, immunoreactive AR protein is induced by both TPA and E2 by 6- to 8-fold and 2- to 4-fold, respectively.	Tetradecanoylphorbol Acetate	58-61	amphiregulin	Homo sapiens	28-30
7590880-5	1995	Activation of B cells [phorbol myristate acetate (PMA), surface immunoglobulin cross-linking alone or in the presence of interleukin-2 (IL-2)] induced CD44E (variable exon V8-10), R2 (VIO) and CD44 isoforms containing exons V6 and/or V7 (CD44 V6/V7).	Tetradecanoylphorbol Acetate	23-48	CD44 molecule (Indian blood group)	Homo sapiens	193-197
7590880-5	1995	Activation of B cells [phorbol myristate acetate (PMA), surface immunoglobulin cross-linking alone or in the presence of interleukin-2 (IL-2)] induced CD44E (variable exon V8-10), R2 (VIO) and CD44 isoforms containing exons V6 and/or V7 (CD44 V6/V7).	Tetradecanoylphorbol Acetate	23-48	CD44 molecule (Indian blood group)	Homo sapiens	193-197
7649107-6	1995	The PKC-modulating drugs, bryostatin and H-7, and antiestrogens (ICI 164,384 and 4-hydroxytamoxifen) interfere with AR induction by TPA and estrogen, respectively.	Tetradecanoylphorbol Acetate	132-135	amphiregulin	Homo sapiens	116-118
33044016-11	2021	These results provide evidence that miR-1696 targeted GPx3 activities in neutrophils could be used to regulate the NETs formation stimulated by PMA.	Tetradecanoylphorbol Acetate	144-147	microRNA 1696	Gallus gallus	36-44
7649107-7	1995	The effects of TPA and E2 on the induction of AR mRNA were both closely associated with enhanced transcription of the AR gene.	Tetradecanoylphorbol Acetate	15-18	amphiregulin	Homo sapiens	46-48
7649107-7	1995	The effects of TPA and E2 on the induction of AR mRNA were both closely associated with enhanced transcription of the AR gene.	Tetradecanoylphorbol Acetate	15-18	amphiregulin	Homo sapiens	118-120
7590880-5	1995	Activation of B cells [phorbol myristate acetate (PMA), surface immunoglobulin cross-linking alone or in the presence of interleukin-2 (IL-2)] induced CD44E (variable exon V8-10), R2 (VIO) and CD44 isoforms containing exons V6 and/or V7 (CD44 V6/V7).	Tetradecanoylphorbol Acetate	50-53	CD44 molecule (Indian blood group)	Homo sapiens	151-155
33760219-8	2021	BTK inhibitors [ibrutinib (10 microM), CNX-774 (10 microM)] significantly attenuated TPA-induced cell invasion and migration in MCF-7 cells and inhibited the activation of the phospholipase Cgamma2/PKCbeta signaling pathways.	Tetradecanoylphorbol Acetate	85-88	Bruton tyrosine kinase	Homo sapiens	0-3
7649107-8	1995	However, TPA had an additional effect at the posttranscriptional level by stabilizing the AR mRNA.	Tetradecanoylphorbol Acetate	9-12	amphiregulin	Homo sapiens	90-92
7649107-9	1995	The protein synthesis inhibitor, cycloheximide, prevented AR induction by TPA, suggesting that a component of the TPA induction of AR is indirect and dependent upon protein synthesis.	Tetradecanoylphorbol Acetate	74-77	amphiregulin	Homo sapiens	58-60
7649107-9	1995	The protein synthesis inhibitor, cycloheximide, prevented AR induction by TPA, suggesting that a component of the TPA induction of AR is indirect and dependent upon protein synthesis.	Tetradecanoylphorbol Acetate	74-77	amphiregulin	Homo sapiens	131-133
7657802-4	1995	During cardiocyte hypertrophy evoked by endothelin-1, Phenylephrine, or PMA, the steady state level of BNP mRNA increased as rapidly as the "immediate-early" induction of the c-fos gene expression, and reached a maximal level within 1 h. Actinomycin D, a transcriptional inhibitor, completely diminished the response, while the translational blocked with cycloheximide did not inhibit it.	Tetradecanoylphorbol Acetate	72-75	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	175-180
7649107-9	1995	The protein synthesis inhibitor, cycloheximide, prevented AR induction by TPA, suggesting that a component of the TPA induction of AR is indirect and dependent upon protein synthesis.	Tetradecanoylphorbol Acetate	114-117	amphiregulin	Homo sapiens	58-60
33760219-10	2021	Collectively, results of the present study indicated that BTK suppressed TPA-induced MMP-9 expression and cell invasion/migration by activating the MAPK or IkappaB kinase/NF-kappaB/activator protein-1 pathway.	Tetradecanoylphorbol Acetate	73-76	Bruton tyrosine kinase	Homo sapiens	58-61
7649107-9	1995	The protein synthesis inhibitor, cycloheximide, prevented AR induction by TPA, suggesting that a component of the TPA induction of AR is indirect and dependent upon protein synthesis.	Tetradecanoylphorbol Acetate	114-117	amphiregulin	Homo sapiens	131-133
7649107-11	1995	The results presented herein thus demonstrate that TPA and E2 are able to stimulate AR gene transcription by two separate mechanisms.	Tetradecanoylphorbol Acetate	51-54	amphiregulin	Homo sapiens	84-86
7480087-3	1995	Staurosporine and H-7, protein kinase C (PKC) inhibitors, suppressed the increase of mRNA and PGE2 levels caused by TPA, but not that caused by EGF.	Tetradecanoylphorbol Acetate	116-119	solute carrier family 9 member A2	Rattus norvegicus	18-21
33760219-10	2021	Collectively, results of the present study indicated that BTK suppressed TPA-induced MMP-9 expression and cell invasion/migration by activating the MAPK or IkappaB kinase/NF-kappaB/activator protein-1 pathway.	Tetradecanoylphorbol Acetate	73-76	matrix metallopeptidase 9	Homo sapiens	85-90
8532957-7	1995	Furthermore, both TU/BAL and KN/LN represented a profile of Th1-like cells: they secreted IL-2 and IFN-gamma, but not IL-4, IL-5 and IL-6, when stimulated with PHA in the presence or absence of 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	194-230	negative elongation factor complex member C/D	Homo sapiens	60-63
7642607-8	1995	TIMP-3 gene expression was inducible by AP-1 and NF-KB activators, 12-O-tetradecanoylphorbol-13-acetate, and tumor necrosis factor-alpha only in preneoplastic cells with an induction peak at 2 h post-treatment, suggesting classification of mTIMP-3 as a member of the immediate early gene family.	Tetradecanoylphorbol Acetate	67-103	TIMP metallopeptidase inhibitor 3	Homo sapiens	0-6
33788722-5	2021	The induction of IL-17 and other inflammatory cytokines by TPA was also suppressed by mPGES-1 deficiency, although DMBA-induced apoptosis was not affected.	Tetradecanoylphorbol Acetate	59-62	interleukin 17A	Mus musculus	17-22
33421194-5	2021	Ether-linked lipids containing an alkyl moiety with a medium chain length (C11-C14) were uniquely upregulated, and the administration of their biosynthetic precursor 1-O-dodecyl-rac-glycerol attenuated phorbol 12-myristate 13-acetate (PMA) induced vascular cell adhesion molecule-1 (VCAM-1) expression.	Tetradecanoylphorbol Acetate	202-233	aldo-keto reductase family 1 member C4	Homo sapiens	74-82
7543105-10	1995	The addition of the phorbol ester phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, to monolayers of human skin fibroblasts, increased vitronectin degradation.	Tetradecanoylphorbol Acetate	34-65	vitronectin	Homo sapiens	154-165
7543105-10	1995	The addition of the phorbol ester phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, to monolayers of human skin fibroblasts, increased vitronectin degradation.	Tetradecanoylphorbol Acetate	67-70	vitronectin	Homo sapiens	154-165
7614710-8	1995	Phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, caused rapid desensitization of the receptor-mediated IP3 response.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, gamma	Rattus norvegicus	41-57
7614710-8	1995	Phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, caused rapid desensitization of the receptor-mediated IP3 response.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, gamma	Rattus norvegicus	59-62
7614710-8	1995	Phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, caused rapid desensitization of the receptor-mediated IP3 response.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, gamma	Rattus norvegicus	41-57
7614710-8	1995	Phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, caused rapid desensitization of the receptor-mediated IP3 response.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, gamma	Rattus norvegicus	59-62
7614710-10	1995	The specific PKC inhibitor GF109203X or PKC depletion by prolonged treatment with 1 mumol/L PMA completely blocked the PMA-dependent desensitization.	Tetradecanoylphorbol Acetate	92-95	protein kinase C, gamma	Rattus norvegicus	13-16
7614710-10	1995	The specific PKC inhibitor GF109203X or PKC depletion by prolonged treatment with 1 mumol/L PMA completely blocked the PMA-dependent desensitization.	Tetradecanoylphorbol Acetate	92-95	protein kinase C, gamma	Rattus norvegicus	40-43
7614710-10	1995	The specific PKC inhibitor GF109203X or PKC depletion by prolonged treatment with 1 mumol/L PMA completely blocked the PMA-dependent desensitization.	Tetradecanoylphorbol Acetate	119-122	protein kinase C, gamma	Rattus norvegicus	13-16
7614710-10	1995	The specific PKC inhibitor GF109203X or PKC depletion by prolonged treatment with 1 mumol/L PMA completely blocked the PMA-dependent desensitization.	Tetradecanoylphorbol Acetate	119-122	protein kinase C, gamma	Rattus norvegicus	40-43
8530184-5	1995	Our results indicate that stimuli related to protein kinase C (PKC) such as the phorbol ester phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 increase ICAM-1 mRNA expression, whereas cyclic nucleotide analogs and PKA agonists have no effect.	Tetradecanoylphorbol Acetate	94-125	intercellular adhesion molecule 1	Rattus norvegicus	170-176
7614738-3	1995	Constitutive lipocortin 1 was detected in U937 myelomonocytic leukemia cells, and lipocortin 1 was increased by treatment with PMA or PMA+IFN-gamma (P &lt; 0.05) but not by dexamethasone.	Tetradecanoylphorbol Acetate	127-130	annexin A1	Homo sapiens	82-94
33421194-5	2021	Ether-linked lipids containing an alkyl moiety with a medium chain length (C11-C14) were uniquely upregulated, and the administration of their biosynthetic precursor 1-O-dodecyl-rac-glycerol attenuated phorbol 12-myristate 13-acetate (PMA) induced vascular cell adhesion molecule-1 (VCAM-1) expression.	Tetradecanoylphorbol Acetate	235-238	aldo-keto reductase family 1 member C4	Homo sapiens	74-82
8530184-5	1995	Our results indicate that stimuli related to protein kinase C (PKC) such as the phorbol ester phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 increase ICAM-1 mRNA expression, whereas cyclic nucleotide analogs and PKA agonists have no effect.	Tetradecanoylphorbol Acetate	127-130	intercellular adhesion molecule 1	Rattus norvegicus	170-176
33035505-8	2020	The PKC activator PMA, but not the diacylglycerol analogue OAG, stimulated ICa1.2 in a concentration-dependent manner; conversely, the PKCalpha inhibitor Go6976 markedly reduced basal ICa1.2 and, similarly to the PKCdelta (rottlerin) and PKCepsilon translocation inhibitors antagonised PMA-induced current stimulation.	Tetradecanoylphorbol Acetate	18-21	protein kinase C, alpha	Rattus norvegicus	4-7
11725057-7	1995	Both the AP-1/AP-2/SP-1 dyad protein binding region and, to a lesser extent, the YY1 tandem-repeat cluster conferred responsiveness to TPA when placed upstream of a heterologous promoter in transient expression assays.	Tetradecanoylphorbol Acetate	135-138	transcription factor AP-2 alpha	Homo sapiens	14-18
7626081-5	1995	Unlike fMLP, phorbol myristate acetate (PMA) induced a concentration-dependent translocation of the PKC isoforms, which persisted in the membrane in the absence of external calcium.	Tetradecanoylphorbol Acetate	13-38	protein kinase C zeta	Homo sapiens	100-103
7626081-5	1995	Unlike fMLP, phorbol myristate acetate (PMA) induced a concentration-dependent translocation of the PKC isoforms, which persisted in the membrane in the absence of external calcium.	Tetradecanoylphorbol Acetate	40-43	protein kinase C zeta	Homo sapiens	100-103
33035505-8	2020	The PKC activator PMA, but not the diacylglycerol analogue OAG, stimulated ICa1.2 in a concentration-dependent manner; conversely, the PKCalpha inhibitor Go6976 markedly reduced basal ICa1.2 and, similarly to the PKCdelta (rottlerin) and PKCepsilon translocation inhibitors antagonised PMA-induced current stimulation.	Tetradecanoylphorbol Acetate	18-21	protein kinase C, alpha	Rattus norvegicus	135-143
7624133-9	1995	These results suggest that TRRS negatively regulates the transcriptional activation function of SRF, and consequently contributes to the low basal activity at the CArG box before TPA induction.	Tetradecanoylphorbol Acetate	179-182	serum response factor	Homo sapiens	96-99
7616215-1	1995	Stimulation of cultured cerebellar granule cells with N-methyl-D-aspartate (NMDA) or kainic acid (KA) leads to activation of activator protein-1 (AP-1) DNA-binding activity, which can be monitored by an increase in 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive element (TRE)-binding activity, in concert with c-fos induction.	Tetradecanoylphorbol Acetate	215-251	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	125-144
7616215-1	1995	Stimulation of cultured cerebellar granule cells with N-methyl-D-aspartate (NMDA) or kainic acid (KA) leads to activation of activator protein-1 (AP-1) DNA-binding activity, which can be monitored by an increase in 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive element (TRE)-binding activity, in concert with c-fos induction.	Tetradecanoylphorbol Acetate	215-251	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	146-150
7616215-1	1995	Stimulation of cultured cerebellar granule cells with N-methyl-D-aspartate (NMDA) or kainic acid (KA) leads to activation of activator protein-1 (AP-1) DNA-binding activity, which can be monitored by an increase in 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive element (TRE)-binding activity, in concert with c-fos induction.	Tetradecanoylphorbol Acetate	215-251	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	317-322
7616215-1	1995	Stimulation of cultured cerebellar granule cells with N-methyl-D-aspartate (NMDA) or kainic acid (KA) leads to activation of activator protein-1 (AP-1) DNA-binding activity, which can be monitored by an increase in 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive element (TRE)-binding activity, in concert with c-fos induction.	Tetradecanoylphorbol Acetate	253-256	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	125-144
7616215-1	1995	Stimulation of cultured cerebellar granule cells with N-methyl-D-aspartate (NMDA) or kainic acid (KA) leads to activation of activator protein-1 (AP-1) DNA-binding activity, which can be monitored by an increase in 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive element (TRE)-binding activity, in concert with c-fos induction.	Tetradecanoylphorbol Acetate	253-256	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	146-150
7637391-0	1995	The protein kinase C inhibitor H7 blocks phosphorylation of stathmin during TPA-induced growth inhibition of human pre-B leukemia REH6 cells.	Tetradecanoylphorbol Acetate	76-79	prolactin regulatory element binding	Homo sapiens	115-120
33035505-8	2020	The PKC activator PMA, but not the diacylglycerol analogue OAG, stimulated ICa1.2 in a concentration-dependent manner; conversely, the PKCalpha inhibitor Go6976 markedly reduced basal ICa1.2 and, similarly to the PKCdelta (rottlerin) and PKCepsilon translocation inhibitors antagonised PMA-induced current stimulation.	Tetradecanoylphorbol Acetate	286-289	protein kinase C, alpha	Rattus norvegicus	4-7
33035505-8	2020	The PKC activator PMA, but not the diacylglycerol analogue OAG, stimulated ICa1.2 in a concentration-dependent manner; conversely, the PKCalpha inhibitor Go6976 markedly reduced basal ICa1.2 and, similarly to the PKCdelta (rottlerin) and PKCepsilon translocation inhibitors antagonised PMA-induced current stimulation.	Tetradecanoylphorbol Acetate	286-289	protein kinase C, alpha	Rattus norvegicus	135-143
7539928-6	1995	Induction of c-fos and c-jun expression by TPA was inhibited by both herbimycin A and calphostin C, suggesting that both PKC and TK pathways are necessary for the induction of the TPA-induced transcription factor AP1, which is a known TPA-inducible early immediate gene product.	Tetradecanoylphorbol Acetate	43-46	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-18
33011272-3	2020	Activation of NADPH oxidase-2 (NOX-2) in neutrophils by stimulators of protein kinase C (PKC), such as phorbol myristate acetate (PMA), results in the rapid generation of superoxide at the expense of oxidation of NADPH to NADP+.	Tetradecanoylphorbol Acetate	103-128	cytochrome b-245 beta chain	Homo sapiens	14-29
7539928-6	1995	Induction of c-fos and c-jun expression by TPA was inhibited by both herbimycin A and calphostin C, suggesting that both PKC and TK pathways are necessary for the induction of the TPA-induced transcription factor AP1, which is a known TPA-inducible early immediate gene product.	Tetradecanoylphorbol Acetate	43-46	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	23-28
7539928-6	1995	Induction of c-fos and c-jun expression by TPA was inhibited by both herbimycin A and calphostin C, suggesting that both PKC and TK pathways are necessary for the induction of the TPA-induced transcription factor AP1, which is a known TPA-inducible early immediate gene product.	Tetradecanoylphorbol Acetate	43-46	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	213-216
7539928-6	1995	Induction of c-fos and c-jun expression by TPA was inhibited by both herbimycin A and calphostin C, suggesting that both PKC and TK pathways are necessary for the induction of the TPA-induced transcription factor AP1, which is a known TPA-inducible early immediate gene product.	Tetradecanoylphorbol Acetate	180-183	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-18
7539928-6	1995	Induction of c-fos and c-jun expression by TPA was inhibited by both herbimycin A and calphostin C, suggesting that both PKC and TK pathways are necessary for the induction of the TPA-induced transcription factor AP1, which is a known TPA-inducible early immediate gene product.	Tetradecanoylphorbol Acetate	180-183	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	23-28
7539928-6	1995	Induction of c-fos and c-jun expression by TPA was inhibited by both herbimycin A and calphostin C, suggesting that both PKC and TK pathways are necessary for the induction of the TPA-induced transcription factor AP1, which is a known TPA-inducible early immediate gene product.	Tetradecanoylphorbol Acetate	180-183	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	213-216
7539928-6	1995	Induction of c-fos and c-jun expression by TPA was inhibited by both herbimycin A and calphostin C, suggesting that both PKC and TK pathways are necessary for the induction of the TPA-induced transcription factor AP1, which is a known TPA-inducible early immediate gene product.	Tetradecanoylphorbol Acetate	180-183	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-18
7539928-6	1995	Induction of c-fos and c-jun expression by TPA was inhibited by both herbimycin A and calphostin C, suggesting that both PKC and TK pathways are necessary for the induction of the TPA-induced transcription factor AP1, which is a known TPA-inducible early immediate gene product.	Tetradecanoylphorbol Acetate	180-183	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	23-28
7539928-6	1995	Induction of c-fos and c-jun expression by TPA was inhibited by both herbimycin A and calphostin C, suggesting that both PKC and TK pathways are necessary for the induction of the TPA-induced transcription factor AP1, which is a known TPA-inducible early immediate gene product.	Tetradecanoylphorbol Acetate	180-183	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	213-216
7616215-1	1995	Stimulation of cultured cerebellar granule cells with N-methyl-D-aspartate (NMDA) or kainic acid (KA) leads to activation of activator protein-1 (AP-1) DNA-binding activity, which can be monitored by an increase in 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive element (TRE)-binding activity, in concert with c-fos induction.	Tetradecanoylphorbol Acetate	253-256	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	317-322
7542684-4	1995	Furthermore, when PMN were activated with N-formyl-methionylleucyl-phenylalanine or phorbol myristate acetate in the presence of superoxide dismutase (SOD) and catalase, methemoglobin formation ensued.	Tetradecanoylphorbol Acetate	84-109	hemoglobin subunit gamma 2	Homo sapiens	170-183
7628641-0	1995	Cell-specific effects of RAS oncogene and protein kinase C agonist TPA on P-glycoprotein function.	Tetradecanoylphorbol Acetate	67-70	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	74-88
33011272-3	2020	Activation of NADPH oxidase-2 (NOX-2) in neutrophils by stimulators of protein kinase C (PKC), such as phorbol myristate acetate (PMA), results in the rapid generation of superoxide at the expense of oxidation of NADPH to NADP+.	Tetradecanoylphorbol Acetate	103-128	cytochrome b-245 beta chain	Homo sapiens	31-36
7628641-4	1995	TPA-induced Pgp function shows dissimilar pattern of cell specificity.	Tetradecanoylphorbol Acetate	0-3	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	12-15
33011272-3	2020	Activation of NADPH oxidase-2 (NOX-2) in neutrophils by stimulators of protein kinase C (PKC), such as phorbol myristate acetate (PMA), results in the rapid generation of superoxide at the expense of oxidation of NADPH to NADP+.	Tetradecanoylphorbol Acetate	103-128	2,4-dienoyl-CoA reductase 1	Homo sapiens	14-19
33011272-3	2020	Activation of NADPH oxidase-2 (NOX-2) in neutrophils by stimulators of protein kinase C (PKC), such as phorbol myristate acetate (PMA), results in the rapid generation of superoxide at the expense of oxidation of NADPH to NADP+.	Tetradecanoylphorbol Acetate	130-133	cytochrome b-245 beta chain	Homo sapiens	14-29
7797495-0	1995	The fatty acid bimodal action on superoxide anion production by human adherent monocytes under phorbol 12-myristate 13-acetate or diacylglycerol activation can be explained by the modulation of protein kinase C and p47phox translocation.	Tetradecanoylphorbol Acetate	95-126	neutrophil cytosolic factor 1	Homo sapiens	215-222
7797495-3	1995	At 3 nM and 30 microM, both fatty acids had enhancing and depressing effects, respectively, on PKC translocation and O-.2 production strictly depending on the PMA- or diacylglycerol-stimulated state of the cell.	Tetradecanoylphorbol Acetate	159-162	immunoglobulin kappa variable 1D-39	Homo sapiens	117-121
7775471-6	1995	Thus, the effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) were compared with those of heat shock on the expression, in PBM, of the major HSP, hsp70 and hsp90, using biometabolic labeling, Western and Northern blotting, and gel mobility shift assays.	Tetradecanoylphorbol Acetate	72-75	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	156-159
8527265-10	1995	The thiol captopril and MPG (but not enalaprilat) caused an initial delay in luminol chemiluminescence production by PMA-stimulated neutrophils.	Tetradecanoylphorbol Acetate	117-120	N-methylpurine DNA glycosylase	Homo sapiens	24-27
33011272-3	2020	Activation of NADPH oxidase-2 (NOX-2) in neutrophils by stimulators of protein kinase C (PKC), such as phorbol myristate acetate (PMA), results in the rapid generation of superoxide at the expense of oxidation of NADPH to NADP+.	Tetradecanoylphorbol Acetate	130-133	cytochrome b-245 beta chain	Homo sapiens	31-36
33011272-3	2020	Activation of NADPH oxidase-2 (NOX-2) in neutrophils by stimulators of protein kinase C (PKC), such as phorbol myristate acetate (PMA), results in the rapid generation of superoxide at the expense of oxidation of NADPH to NADP+.	Tetradecanoylphorbol Acetate	130-133	2,4-dienoyl-CoA reductase 1	Homo sapiens	14-19
32750368-6	2020	Phorbol myristate acetate increased alpha1A-adrenoceptor interaction with Rab5 and Rab9 but did not modify it with Rab7.	Tetradecanoylphorbol Acetate	0-25	RAB9A, member RAS oncogene family	Homo sapiens	83-87
8530162-5	1995	TPA treatment also caused a profound change in the IFN-gamma activation of GAF and DIF.	Tetradecanoylphorbol Acetate	0-3	fibroblast growth factor 9	Homo sapiens	75-78
7781604-2	1995	Here we report that SH-PTP1 is phosphorylated on both serine and tyrosine residues in response to thrombin or phorbol myristate acetate (PMA), which increased by 60 and 40%, respectively, SH-PTP1 activity.	Tetradecanoylphorbol Acetate	110-135	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	20-27
7781604-2	1995	Here we report that SH-PTP1 is phosphorylated on both serine and tyrosine residues in response to thrombin or phorbol myristate acetate (PMA), which increased by 60 and 40%, respectively, SH-PTP1 activity.	Tetradecanoylphorbol Acetate	110-135	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	188-195
7781604-2	1995	Here we report that SH-PTP1 is phosphorylated on both serine and tyrosine residues in response to thrombin or phorbol myristate acetate (PMA), which increased by 60 and 40%, respectively, SH-PTP1 activity.	Tetradecanoylphorbol Acetate	137-140	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	20-27
7781604-2	1995	Here we report that SH-PTP1 is phosphorylated on both serine and tyrosine residues in response to thrombin or phorbol myristate acetate (PMA), which increased by 60 and 40%, respectively, SH-PTP1 activity.	Tetradecanoylphorbol Acetate	137-140	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	188-195
32750368-8	2020	Cell stimulation with phorbol myristate acetate induced the alpha1A-adrenoceptors to interact with the late endosomal marker, Rab9, suggesting that the receptors are directed to slow recycling endosomes once they have transited to the Trans-Golgi network to be retrieved to the plasma membrane.	Tetradecanoylphorbol Acetate	22-47	RAB9A, member RAS oncogene family	Homo sapiens	126-130
7541446-5	1995	Treatment with interferon-beta (IFN-beta), platelet-derived growth factor-AA, leukemia inhibitory factor, phorbol 12-myristate 13-acetate, and dibutyryl cyclic AMP stimulated phosphorylation of HSP27 moderately, while IFN-gamma, TNF-beta, basic fibroblast growth factor, epidermal growth factor, or fetal bovine serum did not significantly alter the level of HSP27 phosphorylation.	Tetradecanoylphorbol Acetate	106-137	lymphotoxin alpha	Homo sapiens	229-237
33090557-6	2020	Following ex vivo stimulation with phorbol myristate acetate/ionomycin, PSC patients showed significantly increased numbers of IL-17A-producing peripheral blood CD4+ T cells compared to PBC patients and healthy controls, indicating increased Th17 differentiation in vivo.	Tetradecanoylphorbol Acetate	35-60	interleukin 17A	Homo sapiens	127-133
7598724-2	1995	Endogenous GMF in astrocytes is phosphorylated at the serine (major) and threonine (minor) residues within 15 min after stimulation by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	135-166	glia maturation factor beta	Homo sapiens	11-14
7598724-2	1995	Endogenous GMF in astrocytes is phosphorylated at the serine (major) and threonine (minor) residues within 15 min after stimulation by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	168-171	glia maturation factor beta	Homo sapiens	11-14
7615002-3	1995	Induction of the ATAC gene requires stimulation by both phorbol 12-myristate 13-acetate and Ca2+ ionophore A23187 ("two-signal gene") and is fully abrogated by the immunosuppressive agent cyclosporin A.	Tetradecanoylphorbol Acetate	56-87	X-C motif chemokine ligand 1	Homo sapiens	17-21
7761402-8	1995	The delayed induction of cyclin D1 expression by TPA is observed only in the P-3T3 cells, correlating with mitogenesis.	Tetradecanoylphorbol Acetate	49-52	cyclin D1	Mus musculus	25-34
7761402-9	1995	N-Acetylcysteine does not affect the immediate early pathway but can inhibit the TPA-mediated induction of cyclin D1 and DNA synthesis.	Tetradecanoylphorbol Acetate	81-84	cyclin D1	Mus musculus	107-116
33003440-2	2020	In this paper, we report that podoplanin is coordinately expressed with the CD44 standard (CD44s) and variant (CD44v) isoforms in vivo-in hyperplastic skin after a pro-inflammatory stimulus with 12-O-tetradecanoylphorbol-13-acetate (TPA)-and in vitro-in cell lines representative of different stages of mouse-skin chemical carcinogenesis, as well as in human squamous carcinoma cell (SCC) lines.	Tetradecanoylphorbol Acetate	195-231	CD44 antigen	Mus musculus	76-80
7763256-1	1995	Leukotriene B4 (LTB4) and phorbol 12-myristate 13-acetate (PMA) were found to activate serine/threonine kinase c-Raf-1 (Raf-1) and mitogen-activated protein (MAP) kinase in guinea pig eosinophils.	Tetradecanoylphorbol Acetate	26-57	RAF proto-oncogene serine/threonine-protein kinase	Cavia porcellus	111-118
7480804-7	1995	In contrast to IL-1 beta, treatment with phorbol ester (12-O-tetradecanoyl phorbol-13-acetate, TPA, 10(-10)-10(-6)M) for 24 h significantly inhibited total cellular cPLA2 activity in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	56-93	phospholipase A2 group IVA	Homo sapiens	165-170
32626908-7	2020	Microglia in the group receiving 72 h of PMA stimulation displayed the highest percentage of cells arrested in G0/G1, the highest amount of senescence-associated expression of p53 and p21, and the most prominent secretion of TNF-alpha and IL-1beta.	Tetradecanoylphorbol Acetate	41-44	KRAS proto-oncogene, GTPase	Rattus norvegicus	184-187
7480804-7	1995	In contrast to IL-1 beta, treatment with phorbol ester (12-O-tetradecanoyl phorbol-13-acetate, TPA, 10(-10)-10(-6)M) for 24 h significantly inhibited total cellular cPLA2 activity in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	95-98	phospholipase A2 group IVA	Homo sapiens	165-170
7480804-8	1995	The amount of total cellular cPLA2 protein seen on Western blot remained unchanged following TPA treatment.	Tetradecanoylphorbol Acetate	93-96	phospholipase A2 group IVA	Homo sapiens	29-34
7480804-10	1995	In contrast, TPA may only cause cPLA2 translocation but no increase in cPLA2 protein synthesis, resulting in limited PG synthesis.	Tetradecanoylphorbol Acetate	13-16	phospholipase A2 group IVA	Homo sapiens	32-37
7763256-1	1995	Leukotriene B4 (LTB4) and phorbol 12-myristate 13-acetate (PMA) were found to activate serine/threonine kinase c-Raf-1 (Raf-1) and mitogen-activated protein (MAP) kinase in guinea pig eosinophils.	Tetradecanoylphorbol Acetate	26-57	RAF proto-oncogene serine/threonine-protein kinase	Cavia porcellus	113-118
7763256-1	1995	Leukotriene B4 (LTB4) and phorbol 12-myristate 13-acetate (PMA) were found to activate serine/threonine kinase c-Raf-1 (Raf-1) and mitogen-activated protein (MAP) kinase in guinea pig eosinophils.	Tetradecanoylphorbol Acetate	59-62	RAF proto-oncogene serine/threonine-protein kinase	Cavia porcellus	111-118
7763256-1	1995	Leukotriene B4 (LTB4) and phorbol 12-myristate 13-acetate (PMA) were found to activate serine/threonine kinase c-Raf-1 (Raf-1) and mitogen-activated protein (MAP) kinase in guinea pig eosinophils.	Tetradecanoylphorbol Acetate	59-62	RAF proto-oncogene serine/threonine-protein kinase	Cavia porcellus	113-118
7544154-2	1995	To assess the requirements for papilloma formation and malignant conversion and determine the sensitivity to a chemical promotion stimulus, HK1.fos mice were promoted with 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	172-208	hexokinase 1	Mus musculus	140-143
7544154-3	1995	HK1.fos mice were sensitive to TPA promotion but developed papillomas only after long latency (20-30 weeks of promotion) and in relatively few numbers per animal, suggesting the necessity of an additional genetic event prior to overt lesion formation.	Tetradecanoylphorbol Acetate	31-34	hexokinase 1	Mus musculus	0-3
7544154-4	1995	Consistent with this idea, at 60 weeks, on cessation of TPA promotion, these HK1.fos TPA-papillomas were found to be autonomous, TPA-independent tumors which persisted, grew larger, and converted to malignancy.	Tetradecanoylphorbol Acetate	56-59	hexokinase 1	Mus musculus	77-80
7779868-4	1995	Phorbol ester (TPA) caused rapid depletion of myotube PKC alpha and PKC alpha and PKC delta isoforms from the cytosolic compartment and rapid appearance of these isoforms in the membrane fraction.	Tetradecanoylphorbol Acetate	15-18	protein kinase C, alpha	Rattus norvegicus	54-63
7544154-4	1995	Consistent with this idea, at 60 weeks, on cessation of TPA promotion, these HK1.fos TPA-papillomas were found to be autonomous, TPA-independent tumors which persisted, grew larger, and converted to malignancy.	Tetradecanoylphorbol Acetate	85-88	hexokinase 1	Mus musculus	77-80
31392347-7	2020	While we were able to characterize the uORFs with respect to their exact size and sequential requirements in this cellular context, only TPA stimulation partially overcame the translation-inhibitory activity of the TNFAIP2 uORFs.	Tetradecanoylphorbol Acetate	137-140	TNF alpha induced protein 2	Homo sapiens	215-222
7544154-4	1995	Consistent with this idea, at 60 weeks, on cessation of TPA promotion, these HK1.fos TPA-papillomas were found to be autonomous, TPA-independent tumors which persisted, grew larger, and converted to malignancy.	Tetradecanoylphorbol Acetate	85-88	hexokinase 1	Mus musculus	77-80
7544154-6	1995	These data indicate that epidermal expression of v-fos induces sensitivity to TPA promotion, but since additional genetic events, such as endogenous c-rasHa activation, appear to be required in tumorigenesis, v-fos may predominantly play a role in the mechanism of promotion to achieve papilloma autonomy and TPA independence.	Tetradecanoylphorbol Acetate	78-81	Harvey rat sarcoma virus oncogene	Mus musculus	149-156
7544154-6	1995	These data indicate that epidermal expression of v-fos induces sensitivity to TPA promotion, but since additional genetic events, such as endogenous c-rasHa activation, appear to be required in tumorigenesis, v-fos may predominantly play a role in the mechanism of promotion to achieve papilloma autonomy and TPA independence.	Tetradecanoylphorbol Acetate	309-312	Harvey rat sarcoma virus oncogene	Mus musculus	149-156
7779868-4	1995	Phorbol ester (TPA) caused rapid depletion of myotube PKC alpha and PKC alpha and PKC delta isoforms from the cytosolic compartment and rapid appearance of these isoforms in the membrane fraction.	Tetradecanoylphorbol Acetate	15-18	protein kinase C, alpha	Rattus norvegicus	68-77
32148409-6	2020	Results: Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) or UV-B induced release of GM-CSF in the SP-1 keratinocytes.	Tetradecanoylphorbol Acetate	24-60	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	94-100
7744871-8	1995	The results indicate that the specific binding of ATF3/Jun and a previously uncharacterized factor account for signal-specific transcription in response to EGF or an activated Ha-ras gene in a cell type in which the cooperative action of an activated Ha-ras gene and 12-O-tetradecanoylphorbol-13-acetate cause tumor growth.	Tetradecanoylphorbol Acetate	267-303	Harvey rat sarcoma virus oncogene	Mus musculus	176-182
7744871-8	1995	The results indicate that the specific binding of ATF3/Jun and a previously uncharacterized factor account for signal-specific transcription in response to EGF or an activated Ha-ras gene in a cell type in which the cooperative action of an activated Ha-ras gene and 12-O-tetradecanoylphorbol-13-acetate cause tumor growth.	Tetradecanoylphorbol Acetate	267-303	Harvey rat sarcoma virus oncogene	Mus musculus	251-257
7730629-1	1995	cAMP inhibits PMA-induced IL-2 production at the transcriptional level in EL-4, a mouse lymphoma line.	Tetradecanoylphorbol Acetate	14-17	epilepsy 4	Mus musculus	74-78
7744791-7	1995	Moreover, although phorbol 12-myristate 13-acetate stimulated both the stable translocation of p47phox and p67phox and sustained NADPH oxidase activity, it did not stimulate p21rac2 translocation.	Tetradecanoylphorbol Acetate	19-50	neutrophil cytosolic factor 1	Homo sapiens	95-102
7738187-12	1995	Both 12-O-tetradecanoyl phorbol 13-acetate and 1,25(OH)2D3 activated endogenous PKC, as assessed by inhibition of myristoylated alanine-rich C kinase substrate back-phosphorylation by exogenous PKC.	Tetradecanoylphorbol Acetate	5-42	protein kinase C, alpha	Rattus norvegicus	80-83
7738187-12	1995	Both 12-O-tetradecanoyl phorbol 13-acetate and 1,25(OH)2D3 activated endogenous PKC, as assessed by inhibition of myristoylated alanine-rich C kinase substrate back-phosphorylation by exogenous PKC.	Tetradecanoylphorbol Acetate	5-42	protein kinase C, alpha	Rattus norvegicus	194-197
7536806-3	1995	The activity of both classes of voltage-dependent Ca2+ channels was slightly augmented by the phorbol ester phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), but the effect of PMA was markedly enhanced by the protein phosphatase inhibitor okadaic acid (OKA).	Tetradecanoylphorbol Acetate	141-144	protein kinase C, gamma	Rattus norvegicus	163-179
32148409-6	2020	Results: Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) or UV-B induced release of GM-CSF in the SP-1 keratinocytes.	Tetradecanoylphorbol Acetate	62-65	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	94-100
7536806-3	1995	The activity of both classes of voltage-dependent Ca2+ channels was slightly augmented by the phorbol ester phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), but the effect of PMA was markedly enhanced by the protein phosphatase inhibitor okadaic acid (OKA).	Tetradecanoylphorbol Acetate	141-144	protein kinase C, gamma	Rattus norvegicus	181-184
32148409-10	2020	Western blot analysis showed that TPA enhanced the phosphorylation of PKCdelta and ERK in the keratinocytes.	Tetradecanoylphorbol Acetate	34-37	protein kinase C, delta	Mus musculus	70-78
7492943-6	1995	Treatment of both cells with TPA for 10 min resulted in the translocation of PKC alpha, PKC delta and PKC epsilon to the membrane fraction.	Tetradecanoylphorbol Acetate	29-32	protein kinase C, delta	Mus musculus	88-97
32148409-11	2020	When we examined the effect of ginsenoside Rh3, we identified that ginsenoside Rh3 inhibited the TPA-induced phosphorylation levels of PKCdelta and ERK.	Tetradecanoylphorbol Acetate	97-100	protein kinase C, delta	Mus musculus	135-143
7492943-9	1995	In this condition, the translocation of cPKC alpha, nPKC delta and nPKC epsilon induced by TPA still occurred, however, that of cPKC alpha was reduced more than in the normal condition.	Tetradecanoylphorbol Acetate	91-94	protein kinase C, delta	Mus musculus	52-62
7492943-10	1995	After long-term treatment (17 h) with TPA, cPKC alpha, nPKC delta and nPKC epsilon were down-regulated both in the cytosol and membrane.	Tetradecanoylphorbol Acetate	38-41	protein kinase C, delta	Mus musculus	55-65
7774812-7	1995	Whereas T beta RI levels remained relatively constant, T beta RII expression was strongly induced in TPA-treated skins, prior to the induction of the growth inhibitory response to TGF-beta 1, and its level of expression correlated with growth sensitivity to TGF-beta 1 in vivo and in vitro.	Tetradecanoylphorbol Acetate	101-104	transforming growth factor, beta receptor II	Mus musculus	55-65
31939617-0	2020	Inhibition of TPA-induced metastatic potential by morin hydrate in MCF-7 human breast cancer cells via the Akt/GSK-3beta/c-Fos signaling pathway.	Tetradecanoylphorbol Acetate	14-17	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	121-126
7549920-2	1995	However, whereas in control experiments using Swiss 3T3 cells TPA stimulated phosphorylation of the major PKC substrate, MARCKS, the agent did not induce the phosphorylation of any protein with the electrophoretic mobility pattern of MARCKS in RIE-1 cells.	Tetradecanoylphorbol Acetate	62-65	myristoylated alanine rich protein kinase C substrate	Mus musculus	121-127
31939617-4	2020	The results showed that morin hydrate suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell migration and invasion via the inhibition of matrix metalloproteinase (MMP)-9 activity.	Tetradecanoylphorbol Acetate	49-85	matrix metallopeptidase 9	Homo sapiens	150-182
31939617-4	2020	The results showed that morin hydrate suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell migration and invasion via the inhibition of matrix metalloproteinase (MMP)-9 activity.	Tetradecanoylphorbol Acetate	87-90	matrix metallopeptidase 9	Homo sapiens	150-182
8846884-0	1995	Effect of phorbol myristate acetate (PMA) on P-glycoprotein mediated vincristine resistance of L1210 cells.	Tetradecanoylphorbol Acetate	10-35	phosphoglycolate phosphatase	Mus musculus	45-59
31730933-5	2020	Demonstrated in a respiratory burst assay, response to phorbol 12-myristate 13-acetate stimulus (135 muM) was 10.2-fold greater in peritoneal macrophages isolated from +SS rats compared to nonresponsive + SSp67phox-/- cells, validating that + SS rats were capable of producing NOX2-derived ROS in cells of hematopoietic origin.	Tetradecanoylphorbol Acetate	55-86	cytochrome b-245 beta chain	Rattus norvegicus	277-281
8846884-0	1995	Effect of phorbol myristate acetate (PMA) on P-glycoprotein mediated vincristine resistance of L1210 cells.	Tetradecanoylphorbol Acetate	37-40	phosphoglycolate phosphatase	Mus musculus	45-59
8846884-1	1995	Effect of phorbol myristate acetate (PMA) on P-glycoprotein (P-GP)-mediated vincristine resistance of the multidrug resistant mouse leukemic cell line L1210/VCR was studied by one hour lasting incubation of cells in the presence of PMA, and after three days of cultivation in the presence of the same substance.	Tetradecanoylphorbol Acetate	10-35	phosphoglycolate phosphatase	Mus musculus	45-59
7534073-5	1995	However, when protein kinase C (PKC) was either inhibited by the PKC inhibitor GF 109203X or depleted by a prolonged TPA treatment, the stimulation of MBP phosphorylation by EGF was strongly inhibited.	Tetradecanoylphorbol Acetate	117-120	protein kinase C zeta	Homo sapiens	32-35
7656159-7	1995	Immunocytochemical investigation also confirmed that heparin could inhibit the expression of nuclear oncogene c-fos and c-jun in the MsC stimulated by PMA.	Tetradecanoylphorbol Acetate	151-154	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	110-115
7730383-5	1995	Activation of each isozyme"s kinase activity (with the exception of PKC-zeta) by treatment of these cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate results in isozyme-specific alterations of cell morphology, as well as in a rapid, selective redistribution of the different PKC isozymes to distinct subcellular structures.	Tetradecanoylphorbol Acetate	129-165	protein kinase C zeta	Homo sapiens	68-76
7794805-2	1995	In response to 12-O-tetradecanoylphorbol-13-acetate (TPA), parental U937 cells displayed growth arrest and differentiated into a monocyte/macrophage-like cell line, while PKC-zeta cells underwent death.	Tetradecanoylphorbol Acetate	15-51	protein kinase C zeta	Homo sapiens	171-179
7794805-2	1995	In response to 12-O-tetradecanoylphorbol-13-acetate (TPA), parental U937 cells displayed growth arrest and differentiated into a monocyte/macrophage-like cell line, while PKC-zeta cells underwent death.	Tetradecanoylphorbol Acetate	53-56	protein kinase C zeta	Homo sapiens	171-179
7900855-8	1995	Protein kinase C (PKC) activator 4 beta-phorbol 12-myristate 13-acetate also induced accumulation of alpha 1A/D-AR mRNAs, and PKC inhibitor H-7 completely blocked ANG II-induced accumulation of the alpha 1A/D-AR mRNAs.	Tetradecanoylphorbol Acetate	35-71	protein kinase C, gamma	Rattus norvegicus	0-16
31813339-8	2020	Importantly, DUSP19 silencing and overexpression mediated p-NF-kappaBp65 level, cleaved Caspase-3 expression, and concentration of IL-6 and IL-8 in mouse primary microglia cells were reversed by NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) and NF-kappaB activator 12-myristate 13-acetate (PMA), respectively.Conclusion: These results suggested that DUSP19-mediated SCI-induced apoptosis and inflammation via NF-kappaB signaling and might therefore serve as a potential therapeutic target for SCI.	Tetradecanoylphorbol Acetate	299-302	dual specificity phosphatase 19	Mus musculus	13-19
7900855-8	1995	Protein kinase C (PKC) activator 4 beta-phorbol 12-myristate 13-acetate also induced accumulation of alpha 1A/D-AR mRNAs, and PKC inhibitor H-7 completely blocked ANG II-induced accumulation of the alpha 1A/D-AR mRNAs.	Tetradecanoylphorbol Acetate	35-71	protein kinase C, gamma	Rattus norvegicus	18-21
7794805-5	1995	TPA-induced down-regulation of PKC activity was similar in both cells.	Tetradecanoylphorbol Acetate	0-3	protein kinase C zeta	Homo sapiens	31-34
7794805-7	1995	Expression of gadd45 was induced by TPA in PKC-zeta but not parental cells and occurred as a primary response to TPA and prior to the onset of cell death.	Tetradecanoylphorbol Acetate	36-39	protein kinase C zeta	Homo sapiens	43-51
7794813-4	1995	TPA was found to induce the expression of both the PDGF-A and the PDGF-B chains.	Tetradecanoylphorbol Acetate	0-3	platelet derived growth factor subunit A	Homo sapiens	51-57
7794813-4	1995	TPA was found to induce the expression of both the PDGF-A and the PDGF-B chains.	Tetradecanoylphorbol Acetate	0-3	platelet derived growth factor subunit B	Homo sapiens	66-72
8846884-1	1995	Effect of phorbol myristate acetate (PMA) on P-glycoprotein (P-GP)-mediated vincristine resistance of the multidrug resistant mouse leukemic cell line L1210/VCR was studied by one hour lasting incubation of cells in the presence of PMA, and after three days of cultivation in the presence of the same substance.	Tetradecanoylphorbol Acetate	10-35	phosphoglycolate phosphatase	Mus musculus	61-65
8846884-1	1995	Effect of phorbol myristate acetate (PMA) on P-glycoprotein (P-GP)-mediated vincristine resistance of the multidrug resistant mouse leukemic cell line L1210/VCR was studied by one hour lasting incubation of cells in the presence of PMA, and after three days of cultivation in the presence of the same substance.	Tetradecanoylphorbol Acetate	37-40	phosphoglycolate phosphatase	Mus musculus	45-59
7711210-8	1995	TGF alpha increased basal tPA activity at both stages of follicular development but inhibited activities of uPA in undifferentiated granulosa cells, irrespective of the presence of FSH.	Tetradecanoylphorbol Acetate	26-29	transforming growth factor alpha	Rattus norvegicus	0-9
31432146-4	2019	We used phorbol 12-myristate 13-acetate (PMA), which is known to induce MMP-9 expression and secretion, to stimulate HT1080 cells.	Tetradecanoylphorbol Acetate	8-39	matrix metallopeptidase 9	Homo sapiens	72-77
7651936-2	1995	We previously found that 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced invasion of Matrigel was associated with augmentation of cell motility but not with metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1.	Tetradecanoylphorbol Acetate	25-61	troponin I3, cardiac type	Homo sapiens	267-272
7651936-2	1995	We previously found that 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced invasion of Matrigel was associated with augmentation of cell motility but not with metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1.	Tetradecanoylphorbol Acetate	63-66	troponin I3, cardiac type	Homo sapiens	267-272
8846884-1	1995	Effect of phorbol myristate acetate (PMA) on P-glycoprotein (P-GP)-mediated vincristine resistance of the multidrug resistant mouse leukemic cell line L1210/VCR was studied by one hour lasting incubation of cells in the presence of PMA, and after three days of cultivation in the presence of the same substance.	Tetradecanoylphorbol Acetate	37-40	phosphoglycolate phosphatase	Mus musculus	61-65
8846884-1	1995	Effect of phorbol myristate acetate (PMA) on P-glycoprotein (P-GP)-mediated vincristine resistance of the multidrug resistant mouse leukemic cell line L1210/VCR was studied by one hour lasting incubation of cells in the presence of PMA, and after three days of cultivation in the presence of the same substance.	Tetradecanoylphorbol Acetate	232-235	phosphoglycolate phosphatase	Mus musculus	61-65
7541474-3	1995	Activation of protein kinase C (PKC) by tumor promoter phorbol 12-myrystate 13-acetate (PMA) induced a rapid morphological differentiation and a decrease in GFAP mRNA, whereas the GFAP level remained unchanged.	Tetradecanoylphorbol Acetate	88-91	glial fibrillary acidic protein	Homo sapiens	157-161
7841194-0	1995	Mechanism of regulation of PDGF-A chain gene expression by serum and TPA.	Tetradecanoylphorbol Acetate	69-72	platelet derived growth factor subunit A	Homo sapiens	27-39
7841194-5	1995	We also analyzed the regions of PDGF-A chain gene that respond to serum and TPA by the chloramphenicol acetyltransferase (CAT) assay and the gel retardation assay.	Tetradecanoylphorbol Acetate	76-79	platelet derived growth factor subunit A	Homo sapiens	32-44
31432146-4	2019	We used phorbol 12-myristate 13-acetate (PMA), which is known to induce MMP-9 expression and secretion, to stimulate HT1080 cells.	Tetradecanoylphorbol Acetate	41-44	matrix metallopeptidase 9	Homo sapiens	72-77
7841194-6	1995	The region from TATA to -135 bp has the activity of the basal expression of PDGF-A chain gene and is considered to be involved in down regulation after the treatment with serum and TPA.	Tetradecanoylphorbol Acetate	181-184	platelet derived growth factor subunit A	Homo sapiens	76-88
31632572-7	2019	In an in vitro assay, after treatment with phorbol myristate acetate (PMA), the THP-1 cells differentiated into M2 macrophages and induced COX2/MMP9-dependent invasiveness in GC cells.	Tetradecanoylphorbol Acetate	43-68	matrix metallopeptidase 9	Homo sapiens	144-148
7695161-2	1995	Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes.	Tetradecanoylphorbol Acetate	29-54	integrin subunit alpha M	Homo sapiens	138-143
7695161-2	1995	Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes.	Tetradecanoylphorbol Acetate	56-59	integrin subunit alpha M	Homo sapiens	138-143
7695161-8	1995	The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 also showed inhibitory effects on the increase in intracellular fluorescence intensity of the endothelial cells exposed to PMA-stimulated leukocytes.	Tetradecanoylphorbol Acetate	188-191	integrin subunit alpha M	Homo sapiens	41-46
7695161-8	1995	The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 also showed inhibitory effects on the increase in intracellular fluorescence intensity of the endothelial cells exposed to PMA-stimulated leukocytes.	Tetradecanoylphorbol Acetate	188-191	intercellular adhesion molecule 1	Homo sapiens	58-64
7722418-2	1995	At an extracellular pH (pHo) of 7.4 (nominal absence of CO2-HCO3-), PMA caused a dose-dependent increase in the rate of cellular H+ extrusion with little change in intracellular pH (pHi).	Tetradecanoylphorbol Acetate	68-71	glucose-6-phosphate isomerase	Oryctolagus cuniculus	182-185
7722418-4	1995	PMA-induced changes in pHi were sensitive to bafilomycin A1, but were insensitive to amiloride.	Tetradecanoylphorbol Acetate	0-3	glucose-6-phosphate isomerase	Oryctolagus cuniculus	23-26
7727042-2	1995	We used 7,12-dimethylbenz[a]anthracene-initiated and 12-O-tetradecanoylphorbol-13-acetate-promoted SENCAR mouse skin tumors, which were shown to contain Ha-ras oncogene activated by point mutation at codon 61, as an in vivo model for these studies.	Tetradecanoylphorbol Acetate	53-89	Harvey rat sarcoma virus oncogene	Mus musculus	153-159
31632572-7	2019	In an in vitro assay, after treatment with phorbol myristate acetate (PMA), the THP-1 cells differentiated into M2 macrophages and induced COX2/MMP9-dependent invasiveness in GC cells.	Tetradecanoylphorbol Acetate	70-73	matrix metallopeptidase 9	Homo sapiens	144-148
31339777-8	2019	Cultured murine macrophages were stimulated with phorbol 12-myristate 13-acetate, which downregulated gene expression of TRPA1 (P < 0.01).	Tetradecanoylphorbol Acetate	49-80	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	121-126
7647574-3	1995	Phorbol 12-myristate 13-acetate (PMA) was used as a PKC activator in this study.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, alpha	Rattus norvegicus	52-55
7647574-3	1995	Phorbol 12-myristate 13-acetate (PMA) was used as a PKC activator in this study.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, alpha	Rattus norvegicus	52-55
7647574-4	1995	PKC activity assay revealed that PMA (300 nM) induced a rapid translocation from cytosol to membrane within 1 min and led to an almost complete translocation within 15 min.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, alpha	Rattus norvegicus	0-3
7647574-8	1995	Treatment with PMA (300 nM) for 24 h resulted in the down-regulation of PKC alpha, delta, and epsilon, but not PKC zeta.	Tetradecanoylphorbol Acetate	15-18	protein kinase C, alpha	Rattus norvegicus	72-81
7836403-8	1995	264, 11228-11235), TPA stimulated the phosphorylation of the PKCs substrate, the 85-kDa myristoylated alanine-rich kinase C substrate (MARCKS) protein, in intact keratinocytes, but Ca2+ did not.	Tetradecanoylphorbol Acetate	19-22	myristoylated alanine rich protein kinase C substrate	Mus musculus	135-141
31339777-9	2019	A TRPA1 agonist, cinnamaldehyde, significantly inhibited phorbol 12-myristate 13-acetate-stimulated expression of IL-1beta and chemokine (C-C motif) ligand 2 in macrophages, which were attenuated by pretreatment with a TRPA1 antagonist, HC030031.	Tetradecanoylphorbol Acetate	57-88	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	2-7
7851400-5	1995	Despite a limited in vitro phorbol ester response, an apparent phorbol ester activation of PKC mu was observed when cell cultures, instead of immunoprecipitated enzyme, were treated with either phorbol 12-myristate 13-acetate or 1,2 dioleoyl-sn-glycerol.	Tetradecanoylphorbol Acetate	194-225	protein kinase D1	Homo sapiens	91-97
31339777-9	2019	A TRPA1 agonist, cinnamaldehyde, significantly inhibited phorbol 12-myristate 13-acetate-stimulated expression of IL-1beta and chemokine (C-C motif) ligand 2 in macrophages, which were attenuated by pretreatment with a TRPA1 antagonist, HC030031.	Tetradecanoylphorbol Acetate	57-88	chemokine (C-C motif) ligand 2	Mus musculus	127-157
31339777-9	2019	A TRPA1 agonist, cinnamaldehyde, significantly inhibited phorbol 12-myristate 13-acetate-stimulated expression of IL-1beta and chemokine (C-C motif) ligand 2 in macrophages, which were attenuated by pretreatment with a TRPA1 antagonist, HC030031.	Tetradecanoylphorbol Acetate	57-88	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	219-224
8001266-11	1995	Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate or an increase in intracellular Ca2+ by the Ca2+ ionophore A23187 was sufficient to cause tyrosine phosphorylation of multiple proteins and activation of MAP kinase and RSK.	Tetradecanoylphorbol Acetate	40-71	protein kinase C, gamma	Rattus norvegicus	14-30
31277605-11	2019	CONCLUSIONS: As seen in the present case, CCI may benefit from immediate treatment with intravenous tissue plasminogen activator (IV-tPA).	Tetradecanoylphorbol Acetate	133-136	chromosome 20 open reading frame 181	Homo sapiens	100-128
8001266-11	1995	Activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate or an increase in intracellular Ca2+ by the Ca2+ ionophore A23187 was sufficient to cause tyrosine phosphorylation of multiple proteins and activation of MAP kinase and RSK.	Tetradecanoylphorbol Acetate	40-71	protein kinase C, gamma	Rattus norvegicus	32-35
8538195-15	1995	Curcumin enhances glutathione content and glutathione-S-transferase activity in liver; and it inhibits lipid peroxidation and arachidonic acid metabolism in mouse skin, protein kinase C activity in TPA-treated NIH 3T3 cells, chemically induced ODC and tyrosine protein kinase activities in rat colon, and 8-hydroxyguanosine formation in mouse fibroblasts.	Tetradecanoylphorbol Acetate	198-201	ornithine decarboxylase, structural 1	Mus musculus	244-247
7887916-4	1995	The results showed that the CCK-induced cholesterol esterase secretion could be mimicked by addition of the Ca2+ ionophore A23187 or by transient incubation of AR42J cells with the protein kinase C activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	208-239	cholecystokinin	Rattus norvegicus	28-31
7887916-4	1995	The results showed that the CCK-induced cholesterol esterase secretion could be mimicked by addition of the Ca2+ ionophore A23187 or by transient incubation of AR42J cells with the protein kinase C activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	208-239	carboxyl ester lipase	Rattus norvegicus	40-60
7887916-4	1995	The results showed that the CCK-induced cholesterol esterase secretion could be mimicked by addition of the Ca2+ ionophore A23187 or by transient incubation of AR42J cells with the protein kinase C activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	241-244	cholecystokinin	Rattus norvegicus	28-31
7887916-4	1995	The results showed that the CCK-induced cholesterol esterase secretion could be mimicked by addition of the Ca2+ ionophore A23187 or by transient incubation of AR42J cells with the protein kinase C activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	241-244	carboxyl ester lipase	Rattus norvegicus	40-60
7475951-4	1995	PKC-alpha was mobilized to the membrane fraction by the phorbol ester, TPA, but not by the phosphoinositide-coupled agonists carbachol, methoxamine and substance P (SP).	Tetradecanoylphorbol Acetate	71-74	protein kinase C, alpha	Rattus norvegicus	0-9
30952555-1	2019	Intravenous tissue-plasminogen activator (IV-TPA) treatment in acute ischemic stroke (AIS) patients due to small vessel occlusion (SVO) has been debated because of its small expected benefit and symptomatic intracranial hemorrhage (SICH) risk.	Tetradecanoylphorbol Acetate	45-48	chromosome 20 open reading frame 181	Homo sapiens	12-40
7475951-6	1995	Biochemical assay of total PKC confirmed that cytosolic enzyme activity was significantly reduced by TPA and carbachol to 29% and 75% respectively of control levels.	Tetradecanoylphorbol Acetate	101-104	protein kinase C, alpha	Rattus norvegicus	27-30
7796933-6	1995	Consistently, ionomycin plus low doses of TPA solely reproduced the potent effect of TRH on c-fos transcripts.	Tetradecanoylphorbol Acetate	42-45	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-97
7796933-7	1995	Data collected from TRH and TPA down-regulated cells indicated that TRH probably recruits TPA-dependent PKC isoforms for stimulating c-fos but not jun B transcripts.	Tetradecanoylphorbol Acetate	28-31	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	133-138
7796933-7	1995	Data collected from TRH and TPA down-regulated cells indicated that TRH probably recruits TPA-dependent PKC isoforms for stimulating c-fos but not jun B transcripts.	Tetradecanoylphorbol Acetate	90-93	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	133-138
21043585-7	1995	Treatment of cells with TPA was associated with induction of c-jun and junB mRN A within 1-4 h. The protein products of these transcription factors are known to be part of the transcription factor complex Activator protein 1 (AP-1).	Tetradecanoylphorbol Acetate	24-27	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	61-66
21043585-7	1995	Treatment of cells with TPA was associated with induction of c-jun and junB mRN A within 1-4 h. The protein products of these transcription factors are known to be part of the transcription factor complex Activator protein 1 (AP-1).	Tetradecanoylphorbol Acetate	24-27	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	205-224
7540861-7	1995	To determine the level of CD5 regulation, we activated T cells using phorbol myristate acetate (PMA)/ionomycin and report that CD5 induction was sensitive to actinomycin D (AcD).	Tetradecanoylphorbol Acetate	69-94	CD5 antigen	Mus musculus	26-29
7540861-7	1995	To determine the level of CD5 regulation, we activated T cells using phorbol myristate acetate (PMA)/ionomycin and report that CD5 induction was sensitive to actinomycin D (AcD).	Tetradecanoylphorbol Acetate	96-99	CD5 antigen	Mus musculus	26-29
7785466-4	1995	Inhibition of protein kinase C both by staurosporine (1 x 10(-8) M) and by prolonged incubation with the phorbol ester phorbol 12-myristate 13-acetate (PMA) (1 x 10(-7) M), decreased PTH mRNA levels at 24 h, reaching approximately 40% and 5% of control, respectively.	Tetradecanoylphorbol Acetate	119-150	parathyroid hormone	Bos taurus	183-186
7785466-4	1995	Inhibition of protein kinase C both by staurosporine (1 x 10(-8) M) and by prolonged incubation with the phorbol ester phorbol 12-myristate 13-acetate (PMA) (1 x 10(-7) M), decreased PTH mRNA levels at 24 h, reaching approximately 40% and 5% of control, respectively.	Tetradecanoylphorbol Acetate	152-155	parathyroid hormone	Bos taurus	183-186
21043585-7	1995	Treatment of cells with TPA was associated with induction of c-jun and junB mRN A within 1-4 h. The protein products of these transcription factors are known to be part of the transcription factor complex Activator protein 1 (AP-1).	Tetradecanoylphorbol Acetate	24-27	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	226-230
21043585-8	1995	Indeed, our data prove a rapid induction of AP-1 protein after TPA stimulation, as shown by mobility shift assays.	Tetradecanoylphorbol Acetate	63-66	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	44-48
30668328-6	2019	PG significantly suppressed the phorbol 12-myristate 13-acetate (PMA)-induced increase of matrix metalloproteinase (MMP)-9 expression as well as gelatinolytic MMP-9 activity, which are essential for cancer metastasis.	Tetradecanoylphorbol Acetate	32-63	matrix metallopeptidase 9	Homo sapiens	90-122
7811231-1	1994	The cis-acting region, GM-kappa B/GC-box (positions -95 and -73), within the murine GM-CSF gene promoter is required for maximal induction by stimulation with phorbol-12-myristate acetate (PMA) and calcium ionophore (A23187) in T cells.	Tetradecanoylphorbol Acetate	189-192	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	84-90
7532210-4	1995	Phorbol 12-myristate 13-acetate (PMA), a PKC activator, increased cyclic GMP concentration without glutamate receptor activation.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, gamma	Rattus norvegicus	41-44
7532210-4	1995	Phorbol 12-myristate 13-acetate (PMA), a PKC activator, increased cyclic GMP concentration without glutamate receptor activation.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, gamma	Rattus norvegicus	41-44
7983058-5	1994	DNA binding activity to IdATF sites was clearly decreased during C2 cell differentiation and rapidly reactivated by treatment with either phorbol 12-myristate 13-acetate or serum, which correlated with the induction of endogenous Id2A mRNA expression.	Tetradecanoylphorbol Acetate	138-169	inhibitor of DNA binding 2	Homo sapiens	230-234
30668328-6	2019	PG significantly suppressed the phorbol 12-myristate 13-acetate (PMA)-induced increase of matrix metalloproteinase (MMP)-9 expression as well as gelatinolytic MMP-9 activity, which are essential for cancer metastasis.	Tetradecanoylphorbol Acetate	65-68	matrix metallopeptidase 9	Homo sapiens	90-122
7538636-4	1995	The treatment of multidrug-resistant cells with 100 nM PMA for 2 hours resulted in the activation not of PKC-zeta but of PKC-alpha, with concomitant decrease in vincristine accumulation and increase in P-glycoprotein phosphorylation.	Tetradecanoylphorbol Acetate	55-58	protein kinase C zeta	Homo sapiens	105-113
30579151-2	2019	The plasma turbidity lysis and whole blood tissue Plasminogen Activator-Rotational Thromboelastometry (tPA-ROTEM) assays estimate fibrinolysis under more physiological conditions than clinically used assays.	Tetradecanoylphorbol Acetate	103-106	chromosome 20 open reading frame 181	Homo sapiens	43-71
7538636-5	1995	The exposure of multidrug-resistant cells to 100 nM PMA for 24 hours induced down-regulation not of PKC-zeta but of PKC-alpha, with concurrent decrease in vincristine accumulation, and reduced but still increased P-glycoprotein phosphorylation.	Tetradecanoylphorbol Acetate	52-55	protein kinase C zeta	Homo sapiens	100-108
7857987-5	1995	Insulin was unable to produce a redistribution of PKC, whereas phorbol 12-myristate 13-acetate (PMA) increased membrane associated PKC twofold.	Tetradecanoylphorbol Acetate	63-94	protein kinase C, gamma	Rattus norvegicus	131-134
7857987-5	1995	Insulin was unable to produce a redistribution of PKC, whereas phorbol 12-myristate 13-acetate (PMA) increased membrane associated PKC twofold.	Tetradecanoylphorbol Acetate	96-99	protein kinase C, gamma	Rattus norvegicus	131-134
7982951-8	1994	In addition, the mutants were expressed in Chinese hamster ovary cells for analysis of the ability of the receptor to mediate BDNF-stimulated transcription from a 12-O-tetradecanoylphorbol-13-acetate response element (TRE).	Tetradecanoylphorbol Acetate	163-199	brain-derived neurotrophic factor	Cricetulus griseus	126-130
7713192-7	1994	The phorbol ester, phorbol myristate acetate (PMA), caused a significant 2-3 fold increase in AP-1 DNA binding, which was sustained for 24 h and completely attenuated by co-incubation with dexamethasone.	Tetradecanoylphorbol Acetate	19-44	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	94-98
7713192-7	1994	The phorbol ester, phorbol myristate acetate (PMA), caused a significant 2-3 fold increase in AP-1 DNA binding, which was sustained for 24 h and completely attenuated by co-incubation with dexamethasone.	Tetradecanoylphorbol Acetate	46-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	94-98
30579151-10	2019	In these patients, the tPA-ROTEM results depended on FII, FXII, plasminogen, alpha2-antiplasmin, PAI-1 and TAFI levels.	Tetradecanoylphorbol Acetate	23-26	serpin family F member 2	Homo sapiens	77-95
30415531-4	2019	In detail, pLTA decreased the production of IL-10 by phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells stimulated with prostaglandin E2 (PGE-2) and LPS.	Tetradecanoylphorbol Acetate	53-84	interleukin 10	Homo sapiens	44-49
7747595-9	1994	Treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) transiently suppressed BDNF mRNA.	Tetradecanoylphorbol Acetate	15-52	brain derived neurotrophic factor	Homo sapiens	82-86
7747595-9	1994	Treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) transiently suppressed BDNF mRNA.	Tetradecanoylphorbol Acetate	54-57	brain derived neurotrophic factor	Homo sapiens	82-86
7747595-10	1994	Treatment with both serum and TPA first stimulated and then transiently suppressed BDNF mRNA.	Tetradecanoylphorbol Acetate	30-33	brain derived neurotrophic factor	Homo sapiens	83-87
30415531-4	2019	In detail, pLTA decreased the production of IL-10 by phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells stimulated with prostaglandin E2 (PGE-2) and LPS.	Tetradecanoylphorbol Acetate	86-89	interleukin 10	Homo sapiens	44-49
7864828-4	1995	Gel-retardation assay indicates Fos as a component of the complex formed between the consensus oligonucleotide of the TPA (PMA, phorbol 12-myristate 13-acetate) response element (TRE) and nuclear extract prepared from butyrate-treated cells.	Tetradecanoylphorbol Acetate	118-121	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	32-35
30522955-5	2019	Notably, the novel pseudotripeptides influenced inflammatory cytokine expression (IL-1beta, IL-18, and TNF-alpha) in Abeta25-35-, PMA-, and LPS-treated THP-1 cells.	Tetradecanoylphorbol Acetate	130-133	interleukin 18	Homo sapiens	92-97
7864828-4	1995	Gel-retardation assay indicates Fos as a component of the complex formed between the consensus oligonucleotide of the TPA (PMA, phorbol 12-myristate 13-acetate) response element (TRE) and nuclear extract prepared from butyrate-treated cells.	Tetradecanoylphorbol Acetate	123-126	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	32-35
7864828-4	1995	Gel-retardation assay indicates Fos as a component of the complex formed between the consensus oligonucleotide of the TPA (PMA, phorbol 12-myristate 13-acetate) response element (TRE) and nuclear extract prepared from butyrate-treated cells.	Tetradecanoylphorbol Acetate	128-159	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	32-35
7829270-4	1995	Both DNFB and TPA caused marked induction of ODC, c-fos and c-jun mRNA.	Tetradecanoylphorbol Acetate	14-17	ornithine decarboxylase, structural 1	Mus musculus	45-48
7893348-0	1994	Induction of c-fos in pituitary cells by thyrotrophin-releasing hormone and phorbol 12-myristate 13-acetate depends upon Ca2+ influx.	Tetradecanoylphorbol Acetate	76-107	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-18
7893348-1	1994	The role of cytosolic free Ca2+ ([Ca2+]i) in the induction of the immediate early gene c-fos by TRH or by phorbol 12-myristate 13-acetate (PMA) was studied in the clonal pituitary cell line GH4C1.	Tetradecanoylphorbol Acetate	106-137	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	87-92
7996872-4	1994	Hemin slightly increased the total hemoglobin production of the cells and phorbol diester (TPA), dimethyl sulfoxide (DMSO) and sodium butyrate (SB) increased the expression of megakaryocytic markers (gpIIb/IIIa complex).	Tetradecanoylphorbol Acetate	91-94	integrin subunit alpha 2b	Homo sapiens	200-205
30645596-11	2019	PMA could activate PKCalpha and promote the angiogenesis capacity of human EPCs via NADPH oxidase-mediated, redox-related, MMP-2 and MMP-9 pathways.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	133-138
7704431-0	1994	Phorbol myristate acetate enhances degradation of TRH receptor mRNA in a pituitary cell type-specific manner.	Tetradecanoylphorbol Acetate	0-25	thyrotropin releasing hormone receptor	Mus musculus	50-62
7704431-3	1994	In stably transfected GH pituitary cells, we find that phorbol 12-myristate 13-acetate (PMA), like TRH, down-regulates TRH-R mRNA by increasing the rate of TRH-R mRNA degradation.	Tetradecanoylphorbol Acetate	55-86	thyrotropin releasing hormone receptor	Mus musculus	119-124
7864072-3	1995	TNF-alpha, IL-1 beta and phorbol myristate acetate (PMA) treatment increased AP-1 and NF kappa B DNA binding by up to 200% but decreased CREB binding (38%) over a 60-min time course.	Tetradecanoylphorbol Acetate	25-50	cAMP responsive element binding protein 1	Homo sapiens	137-141
7864072-3	1995	TNF-alpha, IL-1 beta and phorbol myristate acetate (PMA) treatment increased AP-1 and NF kappa B DNA binding by up to 200% but decreased CREB binding (38%) over a 60-min time course.	Tetradecanoylphorbol Acetate	52-55	cAMP responsive element binding protein 1	Homo sapiens	137-141
7704431-3	1994	In stably transfected GH pituitary cells, we find that phorbol 12-myristate 13-acetate (PMA), like TRH, down-regulates TRH-R mRNA by increasing the rate of TRH-R mRNA degradation.	Tetradecanoylphorbol Acetate	55-86	thyrotropin releasing hormone receptor	Mus musculus	156-161
31026389-10	2019	In addition, Pra-B attenuated TPA-induced nuclear translocation of NF-kappaB-p65/-p50, which reduced Ikk-alpha phosphorylation in HeLa cells.	Tetradecanoylphorbol Acetate	30-33	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	101-110
7704431-3	1994	In stably transfected GH pituitary cells, we find that phorbol 12-myristate 13-acetate (PMA), like TRH, down-regulates TRH-R mRNA by increasing the rate of TRH-R mRNA degradation.	Tetradecanoylphorbol Acetate	88-91	thyrotropin releasing hormone receptor	Mus musculus	119-124
7704431-3	1994	In stably transfected GH pituitary cells, we find that phorbol 12-myristate 13-acetate (PMA), like TRH, down-regulates TRH-R mRNA by increasing the rate of TRH-R mRNA degradation.	Tetradecanoylphorbol Acetate	88-91	thyrotropin releasing hormone receptor	Mus musculus	156-161
7859347-4	1995	Topical application of crocetin inhibited tumor promoter-caused induction of epidermal ODC activity by TPA (5 nmol).	Tetradecanoylphorbol Acetate	103-106	ornithine decarboxylase, structural 1	Mus musculus	87-90
30618749-5	2018	ISLA significantly decreased phorbol 12-myristate 13-acetate (PMA)-induced increases in matrix metalloproteinase (MMP) activities and suppressed PMA-induced activation of mitogen-activated protein kinase as well as NF-kappaB, which are involved in cancer metastasis.	Tetradecanoylphorbol Acetate	29-60	matrix metallopeptidase 9	Homo sapiens	114-117
16695971-4	1995	TPA treated cells were positive for cathepsin B and MAC387, cell numbers were reduced, and the cells became adherent, confirming terminal monocytic differentiation.	Tetradecanoylphorbol Acetate	0-3	cathepsin B	Homo sapiens	36-47
16695971-4	1995	TPA treated cells were positive for cathepsin B and MAC387, cell numbers were reduced, and the cells became adherent, confirming terminal monocytic differentiation.	Tetradecanoylphorbol Acetate	0-3	S100 calcium binding protein A9	Homo sapiens	52-58
7814423-8	1995	Here we investigate possible molecular mechanisms underlying the reciprocal effects of PKC alpha and PKC beta I. Overexpression of both isoforms enhanced 12-O-tetradecanoyl phorbol-13 acetate-induced expression of the growth regulatory genes c-jun, c-myc, and collagenase and enhanced feedback inhibition of epidermal growth factor receptor binding and cellular levels of diacylglycerol.	Tetradecanoylphorbol Acetate	154-191	protein kinase C, alpha	Rattus norvegicus	87-96
7720404-7	1995	Exposure of BCE cells to thrombin changed the distribution of F-actin and vinculin into a diffuse pattern; a similar alteration was also induced by incubation with PMA.	Tetradecanoylphorbol Acetate	164-167	coagulation factor II, thrombin	Bos taurus	25-33
8788311-3	1995	Twelve-0-tetradecanoylphorbol-13-acetate (TPA) increased c-fos and c-jun expressions in endometrial fibroblasts as estradiol did, and pretreatment with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) reduced the estrogen-inducible c-fos and c-jun expressions.	Tetradecanoylphorbol Acetate	42-45	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-62
8788311-3	1995	Twelve-0-tetradecanoylphorbol-13-acetate (TPA) increased c-fos and c-jun expressions in endometrial fibroblasts as estradiol did, and pretreatment with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) reduced the estrogen-inducible c-fos and c-jun expressions.	Tetradecanoylphorbol Acetate	42-45	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	67-72
8788311-3	1995	Twelve-0-tetradecanoylphorbol-13-acetate (TPA) increased c-fos and c-jun expressions in endometrial fibroblasts as estradiol did, and pretreatment with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) reduced the estrogen-inducible c-fos and c-jun expressions.	Tetradecanoylphorbol Acetate	42-45	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	251-256
8788311-3	1995	Twelve-0-tetradecanoylphorbol-13-acetate (TPA) increased c-fos and c-jun expressions in endometrial fibroblasts as estradiol did, and pretreatment with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) reduced the estrogen-inducible c-fos and c-jun expressions.	Tetradecanoylphorbol Acetate	42-45	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	261-266
7869830-6	1995	TPA induced the expression of PDGF-A mRNA, whereas LPS had no effect.	Tetradecanoylphorbol Acetate	0-3	platelet derived growth factor subunit A	Homo sapiens	30-36
7869830-7	1995	Treatment of TPA-stimulated cells with estrogen caused a 61% and 190% increase in PDGF-A mRNA (p &lt; 0.05) at 48 and 96 hours, respectively.	Tetradecanoylphorbol Acetate	13-16	platelet derived growth factor subunit A	Homo sapiens	82-88
7533872-2	1995	In isolated rat hepatocytes angiotensin II and phorbol 12-myristate 13-acetate (PMA) induce the expression of c-fos.	Tetradecanoylphorbol Acetate	47-78	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	110-115
7533872-2	1995	In isolated rat hepatocytes angiotensin II and phorbol 12-myristate 13-acetate (PMA) induce the expression of c-fos.	Tetradecanoylphorbol Acetate	80-83	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	110-115
7659180-2	1995	Staurosporine, a protein kinase inhibitor with broad profile of inhibitory activity on diverse protein kinases, but not CGP 41,251 substantially inhibited the TPA-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1, CD54) and to a lesser extent also its ligand CD11a.	Tetradecanoylphorbol Acetate	159-162	intercellular adhesion molecule 1	Homo sapiens	188-221
7659180-2	1995	Staurosporine, a protein kinase inhibitor with broad profile of inhibitory activity on diverse protein kinases, but not CGP 41,251 substantially inhibited the TPA-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1, CD54) and to a lesser extent also its ligand CD11a.	Tetradecanoylphorbol Acetate	159-162	intercellular adhesion molecule 1	Homo sapiens	223-229
7659180-2	1995	Staurosporine, a protein kinase inhibitor with broad profile of inhibitory activity on diverse protein kinases, but not CGP 41,251 substantially inhibited the TPA-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1, CD54) and to a lesser extent also its ligand CD11a.	Tetradecanoylphorbol Acetate	159-162	intercellular adhesion molecule 1	Homo sapiens	231-235
8552199-4	1995	TPA treatment induced hairy cell leukemia (HCL) characteristics, given by the membrane CD22 and CD25 expression and TRAP positivity in the majority of the cases tested.	Tetradecanoylphorbol Acetate	0-3	interferon stimulated exonuclease gene 20	Homo sapiens	96-100
7805853-3	1994	cPKC-alpha, nPKC-epsilon or aPKC-zeta expression plasmids each stimulated ANF-promoter activity and expression of a reporter gene under the control of a 12-O-tetradecanoylphorbol 13-acetate-response element (TRE).	Tetradecanoylphorbol Acetate	153-189	natriuretic peptide A	Rattus norvegicus	74-77
7946399-6	1994	Treatment with phorbol myristate acetate or 1-oleoyl-2-acetyl-sn-glycerol produced a dose-related, 2- to 4-fold increase in PTHrP secretion.	Tetradecanoylphorbol Acetate	15-40	parathyroid hormone-like hormone	Rattus norvegicus	124-129
7526863-2	1994	The phorbol ester analogue 4 alpha phorbol had no inhibitory effect and 24 h preincubations with PMA resulted in a characteristic down-regulation of the response indicating that the inhibitory actions were mediated via the activation of protein kinase C. Forskolin in the presence of the phosphodiesterase inhibitor IBMX stimulated intracellular cyclic AMP concentrations by up to eight fold, but did not alter basal nor CNP-stimulated cyclic GMP production.	Tetradecanoylphorbol Acetate	97-100	2',3'-cyclic nucleotide 3' phosphodiesterase	Mus musculus	421-424
7946388-3	1994	This inhibition was reversed when the cells were preincubated with the PKC inhibitor staurosporine for 5 min before the addition of PMA.	Tetradecanoylphorbol Acetate	132-135	Prkca	Cavia porcellus	71-74
7848923-0	1994	Regulation of CD9 expression during 12-O-tetradecanoyl-phorbol-13-acetate- induced differentiation of human myeloid leukemia (HL-60) cells.	Tetradecanoylphorbol Acetate	36-73	CD9 molecule	Homo sapiens	14-17
7848923-3	1994	Although several studies indicate that treatment of specific hematopoietic cells with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), induces CD9 expression, the mechanisms by which CD9 expression is regulated have not been elucidated.	Tetradecanoylphorbol Acetate	106-142	CD9 molecule	Homo sapiens	158-161
7848923-3	1994	Although several studies indicate that treatment of specific hematopoietic cells with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), induces CD9 expression, the mechanisms by which CD9 expression is regulated have not been elucidated.	Tetradecanoylphorbol Acetate	106-142	CD9 molecule	Homo sapiens	198-201
7848923-3	1994	Although several studies indicate that treatment of specific hematopoietic cells with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), induces CD9 expression, the mechanisms by which CD9 expression is regulated have not been elucidated.	Tetradecanoylphorbol Acetate	144-147	CD9 molecule	Homo sapiens	158-161
7848923-3	1994	Although several studies indicate that treatment of specific hematopoietic cells with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), induces CD9 expression, the mechanisms by which CD9 expression is regulated have not been elucidated.	Tetradecanoylphorbol Acetate	144-147	CD9 molecule	Homo sapiens	198-201
7848923-4	1994	Here, we provide evidence that, in HL-60 cells, increases in the level of CD9 protein occur in parallel with TPA-induced differentiation.	Tetradecanoylphorbol Acetate	109-112	CD9 molecule	Homo sapiens	74-77
7848923-5	1994	More than 80% of HL-60 cells exposed to 17 nM TPA become CD9 positive within 24 h. CD9 mRNA levels increase within 8-10 h after starting TPA treatment.	Tetradecanoylphorbol Acetate	46-49	CD9 molecule	Homo sapiens	57-60
7848923-5	1994	More than 80% of HL-60 cells exposed to 17 nM TPA become CD9 positive within 24 h. CD9 mRNA levels increase within 8-10 h after starting TPA treatment.	Tetradecanoylphorbol Acetate	46-49	CD9 molecule	Homo sapiens	83-86
7848923-5	1994	More than 80% of HL-60 cells exposed to 17 nM TPA become CD9 positive within 24 h. CD9 mRNA levels increase within 8-10 h after starting TPA treatment.	Tetradecanoylphorbol Acetate	137-140	CD9 molecule	Homo sapiens	83-86
7848923-9	1994	These results suggest that CD9 expression in TPA-treated HL-60 cells is regulated at the transcriptional level and that activation of transcription occurs subsequent to the production of proteins induced as an immediate-early response to TPA.	Tetradecanoylphorbol Acetate	45-48	CD9 molecule	Homo sapiens	27-30
7848923-9	1994	These results suggest that CD9 expression in TPA-treated HL-60 cells is regulated at the transcriptional level and that activation of transcription occurs subsequent to the production of proteins induced as an immediate-early response to TPA.	Tetradecanoylphorbol Acetate	238-241	CD9 molecule	Homo sapiens	27-30
8556517-9	1994	By comparing the quantity of virus produced in infected cells with the amount of virus produced in chronically infected U1 monocytes and ACH-2 lymphocytes stimulated with phorbol 12-myristate 13-acetate and interleukin-2, the approximate number of infected cells per sample is calculated.	Tetradecanoylphorbol Acetate	171-202	acyl-CoA thioesterase 1	Homo sapiens	137-142
7525295-2	1994	Immunofluorescence flow cytometry analysis revealed a remarkable and very rapid down-regulation of the ICAM-3 cell surface expression upon neutrophil activation with stimulating agents such as phorbol myristate acetate (PMA) or calcium ionophore.	Tetradecanoylphorbol Acetate	193-218	intercellular adhesion molecule 3	Homo sapiens	103-109
7525295-2	1994	Immunofluorescence flow cytometry analysis revealed a remarkable and very rapid down-regulation of the ICAM-3 cell surface expression upon neutrophil activation with stimulating agents such as phorbol myristate acetate (PMA) or calcium ionophore.	Tetradecanoylphorbol Acetate	220-223	intercellular adhesion molecule 3	Homo sapiens	103-109
7859929-8	1994	MARCKS phosphorylation was markedly increased when ovine anterior pituitary cells were exposed to 1 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	107-138	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	0-6
7859929-8	1994	MARCKS phosphorylation was markedly increased when ovine anterior pituitary cells were exposed to 1 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	140-143	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	0-6
7820693-3	1994	To evaluate this possibility, a phorbol ester, TPA (12-O-tetradecanoyl phorbol 13-acetate), was used to activate a key enzyme, protein kinase C (PKC), of the PI pathway in ovariectomized (OVX) rats either primed or not primed with estrogen.	Tetradecanoylphorbol Acetate	47-50	protein kinase C, gamma	Rattus norvegicus	127-143
7820693-3	1994	To evaluate this possibility, a phorbol ester, TPA (12-O-tetradecanoyl phorbol 13-acetate), was used to activate a key enzyme, protein kinase C (PKC), of the PI pathway in ovariectomized (OVX) rats either primed or not primed with estrogen.	Tetradecanoylphorbol Acetate	47-50	protein kinase C, gamma	Rattus norvegicus	145-148
7820693-3	1994	To evaluate this possibility, a phorbol ester, TPA (12-O-tetradecanoyl phorbol 13-acetate), was used to activate a key enzyme, protein kinase C (PKC), of the PI pathway in ovariectomized (OVX) rats either primed or not primed with estrogen.	Tetradecanoylphorbol Acetate	52-89	protein kinase C, gamma	Rattus norvegicus	127-143
7820693-3	1994	To evaluate this possibility, a phorbol ester, TPA (12-O-tetradecanoyl phorbol 13-acetate), was used to activate a key enzyme, protein kinase C (PKC), of the PI pathway in ovariectomized (OVX) rats either primed or not primed with estrogen.	Tetradecanoylphorbol Acetate	52-89	protein kinase C, gamma	Rattus norvegicus	145-148
7948035-7	1994	The amounts of p47-phox and p67-phox translocated to the plasma membrane in response to phorbol myristate acetate (PMA) increased with increasing amounts of cytochrome b-558 in the membrane.	Tetradecanoylphorbol Acetate	88-113	mitochondrially encoded cytochrome b	Homo sapiens	157-169
7948035-7	1994	The amounts of p47-phox and p67-phox translocated to the plasma membrane in response to phorbol myristate acetate (PMA) increased with increasing amounts of cytochrome b-558 in the membrane.	Tetradecanoylphorbol Acetate	115-118	neutrophil cytosolic factor 1	Homo sapiens	15-23
7948035-7	1994	The amounts of p47-phox and p67-phox translocated to the plasma membrane in response to phorbol myristate acetate (PMA) increased with increasing amounts of cytochrome b-558 in the membrane.	Tetradecanoylphorbol Acetate	115-118	mitochondrially encoded cytochrome b	Homo sapiens	157-169
7869421-1	1994	We have already shown that alkylcatechol markedly enhances synthesis/secretion of nerve growth factor (NGF) in cultured mouse fibroblasts and astroglial cells through immediate accumulation of NGF mRNA and that the stimulatory effect of alkylcatechol on NGF synthesis/secretion is synergistically enhanced by the coadministration of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	333-364	nerve growth factor	Mus musculus	82-101
7869421-1	1994	We have already shown that alkylcatechol markedly enhances synthesis/secretion of nerve growth factor (NGF) in cultured mouse fibroblasts and astroglial cells through immediate accumulation of NGF mRNA and that the stimulatory effect of alkylcatechol on NGF synthesis/secretion is synergistically enhanced by the coadministration of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	333-364	nerve growth factor	Mus musculus	103-106
7869421-1	1994	We have already shown that alkylcatechol markedly enhances synthesis/secretion of nerve growth factor (NGF) in cultured mouse fibroblasts and astroglial cells through immediate accumulation of NGF mRNA and that the stimulatory effect of alkylcatechol on NGF synthesis/secretion is synergistically enhanced by the coadministration of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	366-369	nerve growth factor	Mus musculus	82-101
7869421-1	1994	We have already shown that alkylcatechol markedly enhances synthesis/secretion of nerve growth factor (NGF) in cultured mouse fibroblasts and astroglial cells through immediate accumulation of NGF mRNA and that the stimulatory effect of alkylcatechol on NGF synthesis/secretion is synergistically enhanced by the coadministration of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	366-369	nerve growth factor	Mus musculus	103-106
7869421-2	1994	The stimulatory effect on NGF mRNA expression of astroglial cells in culture by 4-methylcatechol (MC), an alkylcatechol, and/or PMA was blocked by treatment of the cells with cycloheximide, suggesting de novo synthesis of some cellular protein(s) is essential for the observed increase in the NGF mRNA level.	Tetradecanoylphorbol Acetate	128-131	nerve growth factor	Mus musculus	26-29
7869421-2	1994	The stimulatory effect on NGF mRNA expression of astroglial cells in culture by 4-methylcatechol (MC), an alkylcatechol, and/or PMA was blocked by treatment of the cells with cycloheximide, suggesting de novo synthesis of some cellular protein(s) is essential for the observed increase in the NGF mRNA level.	Tetradecanoylphorbol Acetate	128-131	nerve growth factor	Mus musculus	293-296
7869421-3	1994	The exposure to MC and/or PMA caused a rapid increase in c-fos mRNA content, which was immediately followed by an increase in c-jun mRNA, prior to NGF mRNA elevation.	Tetradecanoylphorbol Acetate	26-29	nerve growth factor	Mus musculus	147-150
7866310-5	1994	Co-transfection with expression plasmids for c-jun and/or c-fos showed that Jun itself induced the luciferase activity, whereas Fos inhibited both the basal and TPA-induced luciferase activity.	Tetradecanoylphorbol Acetate	161-164	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	128-131
7523156-8	1994	EGF and TNF-alpha could enhance c-fos gene expression when protein kinase C was down-regulated by phorbol ester myristate (PMA).	Tetradecanoylphorbol Acetate	123-126	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	32-37
7925438-11	1994	Similar to PKC-alpha, transient PKC-theta overexpression in murine EL4 thymoma cells caused an approximately 2.5-fold increase in the phorbol-12-myristate-13-acetate-induced transcriptional activation of an interleukin-2 promoter-reporter gene construct.	Tetradecanoylphorbol Acetate	134-165	protein kinase C, theta	Mus musculus	32-41
7926460-7	1994	Stimulation of FSC with phorbol myristate acetate (10(-7) mol/L) or PDGF BB (20 ng/mL) increased steady-state levels of PDGF A-chain and B-chain messenger RNA.	Tetradecanoylphorbol Acetate	24-49	platelet derived growth factor subunit A	Homo sapiens	120-132
21559644-2	1994	Thapsigargin (TG) respectively mimics about 15, 75 and 75% of the ODC, HPx and DNA responses to TPA and these differences persist after chronic treatments.	Tetradecanoylphorbol Acetate	96-99	ornithine decarboxylase, structural 1	Mus musculus	66-69
21559644-6	1994	But the ODC response to TG is greater when this compound is applied 48 h after TPA than after another TG treatment.	Tetradecanoylphorbol Acetate	79-82	ornithine decarboxylase, structural 1	Mus musculus	8-11
7931079-9	1994	OAP confers to Oct-2 responsivity to both TPA/Ca2+ and RA, since specific mutations of the AP-1/OAP-binding site significantly reduce the transactivation by Oct-2 in response to TPA and Ca2+ and abolish the inhibition by RA.	Tetradecanoylphorbol Acetate	178-181	POU class 2 homeobox 2	Homo sapiens	15-20
7931079-9	1994	OAP confers to Oct-2 responsivity to both TPA/Ca2+ and RA, since specific mutations of the AP-1/OAP-binding site significantly reduce the transactivation by Oct-2 in response to TPA and Ca2+ and abolish the inhibition by RA.	Tetradecanoylphorbol Acetate	178-181	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-95
7931079-9	1994	OAP confers to Oct-2 responsivity to both TPA/Ca2+ and RA, since specific mutations of the AP-1/OAP-binding site significantly reduce the transactivation by Oct-2 in response to TPA and Ca2+ and abolish the inhibition by RA.	Tetradecanoylphorbol Acetate	178-181	POU class 2 homeobox 2	Homo sapiens	157-162
7931079-11	1994	Therefore, we propose that the TPA/calcium-activated AP-1/OAP element is the main target of positive or negative regulatory signals influencing the IL-2 octamer motif, through synergism with Oct-2 and antagonism by RAR.	Tetradecanoylphorbol Acetate	31-34	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	53-57
7931079-11	1994	Therefore, we propose that the TPA/calcium-activated AP-1/OAP element is the main target of positive or negative regulatory signals influencing the IL-2 octamer motif, through synergism with Oct-2 and antagonism by RAR.	Tetradecanoylphorbol Acetate	31-34	POU class 2 homeobox 2	Homo sapiens	191-196
7925957-0	1994	ARF1-regulated phospholipase D in human neutrophils is enhanced by PMA and MgATP.	Tetradecanoylphorbol Acetate	67-70	ADP ribosylation factor 1	Homo sapiens	0-4
7943245-4	1994	TPA treatment of these cells for 24 h induced a significant concentration-dependent downregulation of PKC-alpha, but not PKC-zeta.	Tetradecanoylphorbol Acetate	0-3	protein kinase C zeta	Homo sapiens	121-129
8083467-1	1994	Mouse thymoma line EL-4 cells produce cytokines such as interleukin (IL)-2, IL-3, IL-4, IL-10, and granulocyte-macrophage colony-stimulating factor in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	163-194	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	99-147
7871547-5	1994	However, TPA resulted in 100% tumor incidence and 8.8 tumors per mouse after 20 weeks of promotion, and induced epidermal ODC activity.	Tetradecanoylphorbol Acetate	9-12	ornithine decarboxylase, structural 1	Mus musculus	122-125
7525610-5	1994	There is also evidence that cells located in G1 or G2/M phase at the beginning of TPA treatment finally expressed low levels of vimentin.	Tetradecanoylphorbol Acetate	82-85	vimentin	Mus musculus	128-136
7525610-6	1994	On the contrary, cells located in S phase at TPA exposure showed high vimentin levels after treatment.	Tetradecanoylphorbol Acetate	45-48	vimentin	Mus musculus	70-78
7525612-9	1994	In addition, treatment of H-ras transformed cells with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) led to an elevation in ODC mRNA levels not observed in parental 10T1/2 fibroblasts.	Tetradecanoylphorbol Acetate	75-111	Harvey rat sarcoma virus oncogene	Mus musculus	26-31
7525612-9	1994	In addition, treatment of H-ras transformed cells with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) led to an elevation in ODC mRNA levels not observed in parental 10T1/2 fibroblasts.	Tetradecanoylphorbol Acetate	75-111	ornithine decarboxylase, structural 1	Mus musculus	141-144
7525612-9	1994	In addition, treatment of H-ras transformed cells with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) led to an elevation in ODC mRNA levels not observed in parental 10T1/2 fibroblasts.	Tetradecanoylphorbol Acetate	113-116	Harvey rat sarcoma virus oncogene	Mus musculus	26-31
7525612-9	1994	In addition, treatment of H-ras transformed cells with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) led to an elevation in ODC mRNA levels not observed in parental 10T1/2 fibroblasts.	Tetradecanoylphorbol Acetate	113-116	ornithine decarboxylase, structural 1	Mus musculus	141-144
7524684-2	1994	TPA, but not CCK-8, caused translocation of PKC enzyme activity from the cytosol fraction to the membrane fraction.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	44-47
7948035-7	1994	The amounts of p47-phox and p67-phox translocated to the plasma membrane in response to phorbol myristate acetate (PMA) increased with increasing amounts of cytochrome b-558 in the membrane.	Tetradecanoylphorbol Acetate	88-113	neutrophil cytosolic factor 1	Homo sapiens	15-23
7943843-10	1994	Pretreatment with phorbol 12-myristate 13-acetate (100 nM), to stimulate protein kinase C activity, did not alter bradykinin-stimulated prostacyclin production and prevented the inhibition of the response to bradykinin by halothane.	Tetradecanoylphorbol Acetate	18-49	kininogen 1	Bos taurus	208-218
7522129-7	1994	As opposed to peripheral blood lymphocytes (PBL), phorbol 12-myristate 13-acetate (PMA) stimulation of decidual NK cells elicited a rapid increase in the numbers of CD11b-positive cells but not increased fluorescence intensity of CD11b on the stained cells.	Tetradecanoylphorbol Acetate	50-81	integrin subunit alpha M	Homo sapiens	165-170
7522129-7	1994	As opposed to peripheral blood lymphocytes (PBL), phorbol 12-myristate 13-acetate (PMA) stimulation of decidual NK cells elicited a rapid increase in the numbers of CD11b-positive cells but not increased fluorescence intensity of CD11b on the stained cells.	Tetradecanoylphorbol Acetate	83-86	integrin subunit alpha M	Homo sapiens	165-170
7522129-7	1994	As opposed to peripheral blood lymphocytes (PBL), phorbol 12-myristate 13-acetate (PMA) stimulation of decidual NK cells elicited a rapid increase in the numbers of CD11b-positive cells but not increased fluorescence intensity of CD11b on the stained cells.	Tetradecanoylphorbol Acetate	83-86	integrin subunit alpha M	Homo sapiens	230-235
8087866-10	1994	The fact that PKC inhibitor staurosporine blocks PMA- but not CD16-induced downregulation suggests that CD16 downregulation can be achieved via two different pathways: one that is PKC dependent and one that is not.	Tetradecanoylphorbol Acetate	49-52	Fc gamma receptor IIIa	Homo sapiens	104-108
7875527-7	1994	Consequently, the binding activity of c-Jun protein to the TPA-responsive element increases, and this causes the induction of PPET-1 mRNA.	Tetradecanoylphorbol Acetate	59-62	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-43
7883762-7	1994	Furthermore, evidence is presented which indicates a synergistic effect of A23187 and thrombin on the activation of p72syk, and an inhibitory effect of pretreatment with phorbol 12-myristate 13-acetate, a protein kinase C activator, on the activation of p72syk induced by either A23187 or thrombin.	Tetradecanoylphorbol Acetate	170-201	spleen associated tyrosine kinase	Homo sapiens	254-260
7931079-3	1994	We show here that Oct-2, despite the presence of an active transcriptional activation domain, requires TPA/Ca2+-induced signals to strongly transactivate the IL-2 octamer motif in Jurkat T cells.	Tetradecanoylphorbol Acetate	103-106	POU class 2 homeobox 2	Homo sapiens	18-23
7931079-5	1994	The presence of an intact COOH-terminal domain of Oct-2 contributes to both TPA/Ca2+-induced transactivation and the RA-mediated repression.	Tetradecanoylphorbol Acetate	76-79	POU class 2 homeobox 2	Homo sapiens	50-55
7931079-8	1994	Mutations of the genuine octamer-binding site abrogate both the binding of Oct-1 and Oct-2 and the TPA/Ca2+-induced transactivation of the OAP/octamer motif.	Tetradecanoylphorbol Acetate	99-102	POU class 2 homeobox 2	Homo sapiens	85-90
7931079-9	1994	OAP confers to Oct-2 responsivity to both TPA/Ca2+ and RA, since specific mutations of the AP-1/OAP-binding site significantly reduce the transactivation by Oct-2 in response to TPA and Ca2+ and abolish the inhibition by RA.	Tetradecanoylphorbol Acetate	42-45	POU class 2 homeobox 2	Homo sapiens	15-20
7931079-9	1994	OAP confers to Oct-2 responsivity to both TPA/Ca2+ and RA, since specific mutations of the AP-1/OAP-binding site significantly reduce the transactivation by Oct-2 in response to TPA and Ca2+ and abolish the inhibition by RA.	Tetradecanoylphorbol Acetate	42-45	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-95
7931079-9	1994	OAP confers to Oct-2 responsivity to both TPA/Ca2+ and RA, since specific mutations of the AP-1/OAP-binding site significantly reduce the transactivation by Oct-2 in response to TPA and Ca2+ and abolish the inhibition by RA.	Tetradecanoylphorbol Acetate	42-45	POU class 2 homeobox 2	Homo sapiens	157-162
7935392-1	1994	The murine myeloid progenitor cell line 32D was recently shown to undergo monocytic differentiation when protein kinase C-delta (PKC-delta) was overexpressed and activated by 12-O-tetradecanoylphorbol-13-acetate (TPA) (H. Mischak, J.H.	Tetradecanoylphorbol Acetate	175-211	protein kinase C, delta	Mus musculus	105-127
7935392-1	1994	The murine myeloid progenitor cell line 32D was recently shown to undergo monocytic differentiation when protein kinase C-delta (PKC-delta) was overexpressed and activated by 12-O-tetradecanoylphorbol-13-acetate (TPA) (H. Mischak, J.H.	Tetradecanoylphorbol Acetate	175-211	protein kinase C, delta	Mus musculus	129-138
7935392-1	1994	The murine myeloid progenitor cell line 32D was recently shown to undergo monocytic differentiation when protein kinase C-delta (PKC-delta) was overexpressed and activated by 12-O-tetradecanoylphorbol-13-acetate (TPA) (H. Mischak, J.H.	Tetradecanoylphorbol Acetate	213-216	protein kinase C, delta	Mus musculus	105-127
7935392-1	1994	The murine myeloid progenitor cell line 32D was recently shown to undergo monocytic differentiation when protein kinase C-delta (PKC-delta) was overexpressed and activated by 12-O-tetradecanoylphorbol-13-acetate (TPA) (H. Mischak, J.H.	Tetradecanoylphorbol Acetate	213-216	protein kinase C, delta	Mus musculus	129-138
7935392-7	1994	Tyrosine phosphorylation of PKC-delta occurred when PKC-delta-transfected 32D cells were stimulated by TPA (W. Li, H. Mischak, J.-C. Yu, L.-M. Wang, J.F.	Tetradecanoylphorbol Acetate	103-106	protein kinase C, delta	Mus musculus	28-37
7935392-7	1994	Tyrosine phosphorylation of PKC-delta occurred when PKC-delta-transfected 32D cells were stimulated by TPA (W. Li, H. Mischak, J.-C. Yu, L.-M. Wang, J.F.	Tetradecanoylphorbol Acetate	103-106	protein kinase C, delta	Mus musculus	52-61
7935392-17	1994	Tyrosine-phosphorylated PKC-delta was observed only for the membrane fraction after stimulation with PDGF-BB or TPA.	Tetradecanoylphorbol Acetate	112-115	protein kinase C, delta	Mus musculus	24-33
7935392-18	1994	The enzymatic activity of PKC-delta in the membrane fraction also increased after stimulation with TPA or PDGF, providing a positive correlation between PKC-delta tyrosine phosphorylation and its activation.	Tetradecanoylphorbol Acetate	99-102	protein kinase C, delta	Mus musculus	26-35
7935392-18	1994	The enzymatic activity of PKC-delta in the membrane fraction also increased after stimulation with TPA or PDGF, providing a positive correlation between PKC-delta tyrosine phosphorylation and its activation.	Tetradecanoylphorbol Acetate	99-102	protein kinase C, delta	Mus musculus	153-162
7929053-4	1994	When Evi-1 was expressed, transactivation through a 12-O-tetradecanoylphorbol 13-acetate-responsive element was observed in NIH3T3 and P19 cells.	Tetradecanoylphorbol Acetate	52-88	MDS1 and EVI1 complex locus	Mus musculus	5-10
7943237-7	1994	CCK-induced activation of MAP kinase may be mediated by protein kinase C, since 12-O-tetradecanoylphorbol 13-acetate (TPA) mimicked the effect of CCK and staurosporine concentration dependently inhibited the action of CCK.	Tetradecanoylphorbol Acetate	80-116	cholecystokinin	Rattus norvegicus	0-3
7943237-7	1994	CCK-induced activation of MAP kinase may be mediated by protein kinase C, since 12-O-tetradecanoylphorbol 13-acetate (TPA) mimicked the effect of CCK and staurosporine concentration dependently inhibited the action of CCK.	Tetradecanoylphorbol Acetate	80-116	cholecystokinin	Rattus norvegicus	146-149
7943237-7	1994	CCK-induced activation of MAP kinase may be mediated by protein kinase C, since 12-O-tetradecanoylphorbol 13-acetate (TPA) mimicked the effect of CCK and staurosporine concentration dependently inhibited the action of CCK.	Tetradecanoylphorbol Acetate	80-116	cholecystokinin	Rattus norvegicus	146-149
7943237-7	1994	CCK-induced activation of MAP kinase may be mediated by protein kinase C, since 12-O-tetradecanoylphorbol 13-acetate (TPA) mimicked the effect of CCK and staurosporine concentration dependently inhibited the action of CCK.	Tetradecanoylphorbol Acetate	118-121	cholecystokinin	Rattus norvegicus	0-3
7943237-7	1994	CCK-induced activation of MAP kinase may be mediated by protein kinase C, since 12-O-tetradecanoylphorbol 13-acetate (TPA) mimicked the effect of CCK and staurosporine concentration dependently inhibited the action of CCK.	Tetradecanoylphorbol Acetate	118-121	cholecystokinin	Rattus norvegicus	146-149
7943237-7	1994	CCK-induced activation of MAP kinase may be mediated by protein kinase C, since 12-O-tetradecanoylphorbol 13-acetate (TPA) mimicked the effect of CCK and staurosporine concentration dependently inhibited the action of CCK.	Tetradecanoylphorbol Acetate	118-121	cholecystokinin	Rattus norvegicus	146-149
8091139-4	1994	Monoclonal antibody against CD28 had a costimulatory effect on T cells stimulated by phorbol myristate acetate (PMA), concanavalin A or MoAb against TCR.	Tetradecanoylphorbol Acetate	85-110	CD28 molecule	Gallus gallus	28-32
8091139-4	1994	Monoclonal antibody against CD28 had a costimulatory effect on T cells stimulated by phorbol myristate acetate (PMA), concanavalin A or MoAb against TCR.	Tetradecanoylphorbol Acetate	112-115	CD28 molecule	Gallus gallus	28-32
8046240-0	1994	A low molecular weight phagocytosis-inhibitory factor obtained from human erythrocyte membranes specifically down-regulates Mac-1 activity on tetradecanoyl phorbol acetate-stimulated monocytic cell lines in a Ca(2+)-dependent manner.	Tetradecanoylphorbol Acetate	142-171	dermcidin	Homo sapiens	23-53
8046240-0	1994	A low molecular weight phagocytosis-inhibitory factor obtained from human erythrocyte membranes specifically down-regulates Mac-1 activity on tetradecanoyl phorbol acetate-stimulated monocytic cell lines in a Ca(2+)-dependent manner.	Tetradecanoylphorbol Acetate	142-171	integrin subunit alpha M	Homo sapiens	124-129
8039597-5	1994	Also, short-term incubation of ASMCs with the active phorbol ester, phorbol 12-myristate 13-acetate, led to a reduction in peak [Ca2+]i response to all three agonists, whereas the inactive phorbol ester, 4 alpha-phorbol 12,13-didecanoate, which does not activate PKC, had no such effect.	Tetradecanoylphorbol Acetate	68-99	protein kinase C, gamma	Rattus norvegicus	263-266
8045973-8	1994	MMP-9, but not MMP-2, secretion was stimulated by phorbol myristate acetate.	Tetradecanoylphorbol Acetate	50-75	matrix metallopeptidase 9	Homo sapiens	0-5
8037774-1	1994	The expression of pEL98 (also termed mts1), an S100-related calcium-binding protein, was induced during macrophagic or granulocytic differentiation of human promyelocytic leukemia HL-60 cells in response to phorbol 12-myristate 13-acetate or dimethylsulfoxide, respectively.	Tetradecanoylphorbol Acetate	207-238	S100 calcium binding protein A4	Homo sapiens	18-23
8037774-1	1994	The expression of pEL98 (also termed mts1), an S100-related calcium-binding protein, was induced during macrophagic or granulocytic differentiation of human promyelocytic leukemia HL-60 cells in response to phorbol 12-myristate 13-acetate or dimethylsulfoxide, respectively.	Tetradecanoylphorbol Acetate	207-238	S100 calcium binding protein A4	Homo sapiens	37-41
7517419-0	1994	TNF-alpha associated with fibronectin enhances phorbol myristate acetate- or antigen-mediated integrin-dependent adhesion of CD4+ T cells via protein tyrosine phosphorylation.	Tetradecanoylphorbol Acetate	47-72	Cd4 molecule	Rattus norvegicus	125-128
7517419-4	1994	A brief exposure of CD4+ cells to low dosages of soluble TNF-alpha or of FN- or laminin-bound TNF-alpha synergized with PMA to enhance the integrin-mediated binding of CD4+ cells to these immobilized ECM moieties.	Tetradecanoylphorbol Acetate	120-123	Cd4 molecule	Rattus norvegicus	20-23
7517419-4	1994	A brief exposure of CD4+ cells to low dosages of soluble TNF-alpha or of FN- or laminin-bound TNF-alpha synergized with PMA to enhance the integrin-mediated binding of CD4+ cells to these immobilized ECM moieties.	Tetradecanoylphorbol Acetate	120-123	Cd4 molecule	Rattus norvegicus	168-171
7517419-8	1994	Soluble, and to a greater extent FN-bound, TNF-alpha synergizes with PMA to intensify protein tyrosine phosphorylation in FN-bound CD4+ cells, and this effect of TNF-alpha was inhibited by inhibitors of tyrosine kinase.	Tetradecanoylphorbol Acetate	69-72	Cd4 molecule	Rattus norvegicus	131-134
8001904-2	1994	The gene for PDGF A chain is constitutively weakly expressed by MEG-01 cells and strong expression is induced in MEG-01, MOLM-1 and MOLM-7 but not in HEL cells after treatment with PMA for three days.	Tetradecanoylphorbol Acetate	181-184	platelet derived growth factor subunit A	Homo sapiens	13-25
8027214-5	1994	Basal 3 beta HSD activity and progesterone production were inhibited by TPA.	Tetradecanoylphorbol Acetate	72-75	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	6-16
7912755-10	1994	Culture supernatants from blasts cultured with or without TPA showed the production of large amounts of IL-8, IL-6, TNF-alpha, MIP-1 alpha, IL-10 and interferon gamma and modest amounts of IL-1 alpha, GM-CSF and stem cell factor.	Tetradecanoylphorbol Acetate	58-61	interleukin 10	Homo sapiens	140-145
7971144-8	1994	After [Ca2+]i oscillations were induced with OPE or low concentrations of CCK-8 (20 pM), 1 nM TPA caused a gradual slowing of oscillation frequency over 15-20 min without affecting [Ca2+]i spike amplitude.	Tetradecanoylphorbol Acetate	94-97	cholecystokinin	Rattus norvegicus	74-77
7971144-9	1994	In contrast, 1 microM TPA inhibited OPE binding and caused a more generalized inhibition of OPE- and CCK-evoked Ca2+ signals.	Tetradecanoylphorbol Acetate	22-25	cholecystokinin	Rattus norvegicus	101-104
8195229-2	1994	Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	290-326	dual specificity mitogen-activated protein kinase kinase 1	Cricetulus griseus	64-69
8195229-2	1994	Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	290-326	dual specificity mitogen-activated protein kinase kinase 1	Cricetulus griseus	138-143
8195229-2	1994	Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	328-331	dual specificity mitogen-activated protein kinase kinase 1	Cricetulus griseus	64-69
8195229-2	1994	Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	328-331	dual specificity mitogen-activated protein kinase kinase 1	Cricetulus griseus	138-143
8195229-5	1994	These results suggest that 1) signals initiated by insulin and TPA converge on Raf-1 and activate its MAPKKK activity and 2) Raf-1, MAPKK, and mSos not only lie upstream of MAPK but also are phosphorylated by MAPK, directly or indirectly, and at least Raf-1 kinase activity might be down-regulated by this feedback mechanism.	Tetradecanoylphorbol Acetate	63-66	dual specificity mitogen-activated protein kinase kinase 1	Cricetulus griseus	102-107
8183567-1	1994	Transcription of the cytoskeletal beta-actin gene is rapidly induced by phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore, A23187, in cultured H4IIE hepatoma (H4) cells.	Tetradecanoylphorbol Acetate	72-103	POTE ankyrin domain family member F	Homo sapiens	34-44
8183567-1	1994	Transcription of the cytoskeletal beta-actin gene is rapidly induced by phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore, A23187, in cultured H4IIE hepatoma (H4) cells.	Tetradecanoylphorbol Acetate	105-108	POTE ankyrin domain family member F	Homo sapiens	34-44
8073090-2	1994	Topical applications of the procyanidins, 15 min before the tumor promoter, inhibit TPA-induced ornithine decarboxylase (ODC) activity and this inhibition increases with the degree of polymerization (trimer &gt; dimer &gt; monomer).	Tetradecanoylphorbol Acetate	84-87	ornithine decarboxylase, structural 1	Mus musculus	96-119
8073090-2	1994	Topical applications of the procyanidins, 15 min before the tumor promoter, inhibit TPA-induced ornithine decarboxylase (ODC) activity and this inhibition increases with the degree of polymerization (trimer &gt; dimer &gt; monomer).	Tetradecanoylphorbol Acetate	84-87	ornithine decarboxylase, structural 1	Mus musculus	121-124
8073090-3	1994	At a dose of 10 mumol, all procyanidin dimers inhibit the ODC response to TPA to a greater degree than 20 mumol of epicatechin and 10 mumol of epicatechin and/or catechin.	Tetradecanoylphorbol Acetate	74-77	ornithine decarboxylase, structural 1	Mus musculus	58-61
8073090-5	1994	At a dose of 10 mumol, the epicatechin trimer also inhibits TPA-induced ODC activity and HPx production to a greater degree than 10-30 mumol of epicatechin.	Tetradecanoylphorbol Acetate	60-63	ornithine decarboxylase, structural 1	Mus musculus	72-75
8204657-7	1994	Phorbol 12-myristate 13-acetate induced a 4- to 5-fold increase in secreted latent cathepsin B, but did not alter significantly the accumulation of cystatin C in media.	Tetradecanoylphorbol Acetate	0-31	cathepsin B	Homo sapiens	83-94
8182081-3	1994	Inhibition of PKC by bisindolylmaleimide reduced basal GABA uptake 80% and blocked the phorbol 12-myristate 13-acetate (PMA)-induced stimulation of transport.	Tetradecanoylphorbol Acetate	87-118	protein kinase C, gamma	Rattus norvegicus	14-17
8182081-3	1994	Inhibition of PKC by bisindolylmaleimide reduced basal GABA uptake 80% and blocked the phorbol 12-myristate 13-acetate (PMA)-induced stimulation of transport.	Tetradecanoylphorbol Acetate	120-123	protein kinase C, gamma	Rattus norvegicus	14-17
8175801-6	1994	Using in vitro synthesized Jun and Fos, binding to the ARE could not be detected, whereas Jun/Fos binding to a classical AP-1-binding site, a TPA response element (TRE) from the human collagenase gene, could be demonstrated by gel retardation assays.	Tetradecanoylphorbol Acetate	142-145	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	94-97
9397959-8	1994	MARCKS phosphorylation was markedly increased when ovine anterior pituitary cells were exposed to 1 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	107-138	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	0-6
9397959-8	1994	MARCKS phosphorylation was markedly increased when ovine anterior pituitary cells were exposed to 1 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	140-143	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	0-6
8167157-6	1994	The release of CCK-LI from STC-1 cells was stimulated by dibutyryl cAMP, forskolin, KCl, A23187, 4 beta-phorbol 12-myristate 13-acetate and luminal stimulants, e.g., sodium oleate, L-tryptophan, camostat and plaunotol.	Tetradecanoylphorbol Acetate	99-135	cholecystokinin	Canis lupus familiaris	15-18
8137494-9	1994	Treatment of the arteries with phorbol 12-myristate 13-acetate, a potent stimulator of PKC, induced ICAM-1 expression and enhanced the endothelial adhesiveness to PMNs and PMN-induced EDR impairment, mimicking the effects of Ox-LDL.	Tetradecanoylphorbol Acetate	31-62	intercellular adhesion molecule 1	Homo sapiens	100-106
7914348-6	1994	Under conditions in which TPA impairs glucocorticoid induction of TAT mRNA, the glucocorticoid receptor and other proteins binding within the glucocorticoid-inducible enhancer occupy their binding sites, indicating that inhibition occurs at a later step necessary for transcriptional stimulation.	Tetradecanoylphorbol Acetate	26-29	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	80-103
8139548-0	1994	rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.	Tetradecanoylphorbol Acetate	152-155	Rac family small GTPase 1	Homo sapiens	0-3
8134117-7	1994	The expression of HYL was upregulated when these myeloid cells were differentiated by induction with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	101-126	megakaryocyte-associated tyrosine kinase	Homo sapiens	18-21
8135799-1	1994	Calcium has been suggested to be an intracellular second messenger for ornithine decarboxylase (ODC) induction caused by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	121-157	ornithine decarboxylase, structural 1	Mus musculus	71-94
8135799-1	1994	Calcium has been suggested to be an intracellular second messenger for ornithine decarboxylase (ODC) induction caused by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	121-157	ornithine decarboxylase, structural 1	Mus musculus	96-99
8135799-1	1994	Calcium has been suggested to be an intracellular second messenger for ornithine decarboxylase (ODC) induction caused by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	159-162	ornithine decarboxylase, structural 1	Mus musculus	71-94
8135799-1	1994	Calcium has been suggested to be an intracellular second messenger for ornithine decarboxylase (ODC) induction caused by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	159-162	ornithine decarboxylase, structural 1	Mus musculus	96-99
8135799-2	1994	In the present study, the effects of dietary calcium supplement and calcium and verapamil injections on TPA-induced ODC activity in skin was investigated in CD-1 and SENCAR mouse.	Tetradecanoylphorbol Acetate	104-107	ornithine decarboxylase, structural 1	Mus musculus	116-119
8135799-4	1994	However, calcium injections enhanced the TPA-induced ODC activity in CD-1 and SENCAR mouse skin.	Tetradecanoylphorbol Acetate	41-44	ornithine decarboxylase, structural 1	Mus musculus	53-56
8135799-5	1994	Verapamil injections resulted in a significant decrease in TPA-induced ODC activity in CD-1 and SENCAR mice.	Tetradecanoylphorbol Acetate	59-62	ornithine decarboxylase, structural 1	Mus musculus	71-74
7509717-11	1994	Staining for induced ODC in mice treated with 12-O-tetradecanoylphorbol-13-acetate once weekly for 7 weeks was intense and diffuse throughout the suprabasal layers of the epidermis.	Tetradecanoylphorbol Acetate	46-82	ornithine decarboxylase, structural 1	Mus musculus	21-24
8108138-5	1994	TPA down-regulates evi-1 mRNA production and blocks forskolin mediated induction.	Tetradecanoylphorbol Acetate	0-3	MDS1 and EVI1 complex locus	Homo sapiens	19-24
8063812-2	1994	We demonstrate using a human glial cell line (1321N1) that activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) increases beta-APP mRNA levels, induces known components of the transcription factor activator protein-1 (AP-1), and increases protein-DNA binding activity to AP-1 sequences within the beta-APP promoter.	Tetradecanoylphorbol Acetate	101-132	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	224-243
8063812-2	1994	We demonstrate using a human glial cell line (1321N1) that activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) increases beta-APP mRNA levels, induces known components of the transcription factor activator protein-1 (AP-1), and increases protein-DNA binding activity to AP-1 sequences within the beta-APP promoter.	Tetradecanoylphorbol Acetate	101-132	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	245-249
8063812-2	1994	We demonstrate using a human glial cell line (1321N1) that activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) increases beta-APP mRNA levels, induces known components of the transcription factor activator protein-1 (AP-1), and increases protein-DNA binding activity to AP-1 sequences within the beta-APP promoter.	Tetradecanoylphorbol Acetate	101-132	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	298-302
8063812-2	1994	We demonstrate using a human glial cell line (1321N1) that activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) increases beta-APP mRNA levels, induces known components of the transcription factor activator protein-1 (AP-1), and increases protein-DNA binding activity to AP-1 sequences within the beta-APP promoter.	Tetradecanoylphorbol Acetate	134-137	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	224-243
8063812-2	1994	We demonstrate using a human glial cell line (1321N1) that activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) increases beta-APP mRNA levels, induces known components of the transcription factor activator protein-1 (AP-1), and increases protein-DNA binding activity to AP-1 sequences within the beta-APP promoter.	Tetradecanoylphorbol Acetate	134-137	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	245-249
8063812-2	1994	We demonstrate using a human glial cell line (1321N1) that activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) increases beta-APP mRNA levels, induces known components of the transcription factor activator protein-1 (AP-1), and increases protein-DNA binding activity to AP-1 sequences within the beta-APP promoter.	Tetradecanoylphorbol Acetate	134-137	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	298-302
8063739-2	1994	We found previously that this effect of insulin was essentially normal in cells in which protein kinase C (PKC) was down-regulated by 16 h of exposure to 16 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	164-195	protein kinase C, gamma	Rattus norvegicus	89-105
8063739-2	1994	We found previously that this effect of insulin was essentially normal in cells in which protein kinase C (PKC) was down-regulated by 16 h of exposure to 16 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	164-195	protein kinase C, gamma	Rattus norvegicus	107-110
8063739-2	1994	We found previously that this effect of insulin was essentially normal in cells in which protein kinase C (PKC) was down-regulated by 16 h of exposure to 16 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	197-200	protein kinase C, gamma	Rattus norvegicus	89-105
8063739-2	1994	We found previously that this effect of insulin was essentially normal in cells in which protein kinase C (PKC) was down-regulated by 16 h of exposure to 16 microM phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	197-200	protein kinase C, gamma	Rattus norvegicus	107-110
8063739-5	1994	PKC enzyme activity was undetectable in the first two cell types after down-regulation; in addition, in all three cells the expressed PKC isozymes other than PKC zeta were completely down-regulated by the PMA exposure.	Tetradecanoylphorbol Acetate	205-208	protein kinase C, gamma	Rattus norvegicus	0-3
8063739-5	1994	PKC enzyme activity was undetectable in the first two cell types after down-regulation; in addition, in all three cells the expressed PKC isozymes other than PKC zeta were completely down-regulated by the PMA exposure.	Tetradecanoylphorbol Acetate	205-208	protein kinase C, gamma	Rattus norvegicus	134-137
8063739-5	1994	PKC enzyme activity was undetectable in the first two cell types after down-regulation; in addition, in all three cells the expressed PKC isozymes other than PKC zeta were completely down-regulated by the PMA exposure.	Tetradecanoylphorbol Acetate	205-208	protein kinase C, gamma	Rattus norvegicus	134-137
8052650-2	1994	These cells could be largely depleted of the endogenous PKC isozymes by chronic treatment with phorbol 12-myristate 13-acetate followed by permeabilization of the cells with streptolysin O.	Tetradecanoylphorbol Acetate	95-126	protein kinase C, alpha	Rattus norvegicus	56-59
8293569-16	1994	12-O-Tetradecanoylphorbol 13-acetate (TPA, 300 nmol/L) induced translocation of soluble PKC-alpha, PKC-delta, and PKC-epsilon to the particulate fraction at 30 minutes and complete (PKC-alpha and PKC-delta) or 80% (PKC-epsilon) downregulation at 24 hours.	Tetradecanoylphorbol Acetate	0-36	protein kinase C, alpha	Rattus norvegicus	88-97
8293569-16	1994	12-O-Tetradecanoylphorbol 13-acetate (TPA, 300 nmol/L) induced translocation of soluble PKC-alpha, PKC-delta, and PKC-epsilon to the particulate fraction at 30 minutes and complete (PKC-alpha and PKC-delta) or 80% (PKC-epsilon) downregulation at 24 hours.	Tetradecanoylphorbol Acetate	0-36	protein kinase C, alpha	Rattus norvegicus	182-191
8293569-16	1994	12-O-Tetradecanoylphorbol 13-acetate (TPA, 300 nmol/L) induced translocation of soluble PKC-alpha, PKC-delta, and PKC-epsilon to the particulate fraction at 30 minutes and complete (PKC-alpha and PKC-delta) or 80% (PKC-epsilon) downregulation at 24 hours.	Tetradecanoylphorbol Acetate	38-41	protein kinase C, alpha	Rattus norvegicus	88-97
8293569-16	1994	12-O-Tetradecanoylphorbol 13-acetate (TPA, 300 nmol/L) induced translocation of soluble PKC-alpha, PKC-delta, and PKC-epsilon to the particulate fraction at 30 minutes and complete (PKC-alpha and PKC-delta) or 80% (PKC-epsilon) downregulation at 24 hours.	Tetradecanoylphorbol Acetate	38-41	protein kinase C, alpha	Rattus norvegicus	182-191
8113389-2	1994	In this study, transforming growth factor-alpha (TGF alpha) and the tumor promoter, tetradecanoyl phorbol acetate (TPA), are shown to stimulate the production of eicosanoids by rat intestinal epithelial (RIE-1) cells in culture.	Tetradecanoylphorbol Acetate	115-118	transforming growth factor alpha	Rattus norvegicus	15-47
8113389-2	1994	In this study, transforming growth factor-alpha (TGF alpha) and the tumor promoter, tetradecanoyl phorbol acetate (TPA), are shown to stimulate the production of eicosanoids by rat intestinal epithelial (RIE-1) cells in culture.	Tetradecanoylphorbol Acetate	115-118	transforming growth factor alpha	Rattus norvegicus	49-58
30618749-5	2018	ISLA significantly decreased phorbol 12-myristate 13-acetate (PMA)-induced increases in matrix metalloproteinase (MMP) activities and suppressed PMA-induced activation of mitogen-activated protein kinase as well as NF-kappaB, which are involved in cancer metastasis.	Tetradecanoylphorbol Acetate	62-65	matrix metallopeptidase 9	Homo sapiens	114-117
8175888-4	1994	Sequencing revealed identity of the Jurkat clone to a cDNA, termed ETR101, recently isolated from HL60 promyelocytic leukaemia cells and shown to be an immediate early gene expressed upon TPA stimulation of these cells [Shimizu et al.	Tetradecanoylphorbol Acetate	188-191	immediate early response 2	Homo sapiens	67-73
30404828-6	2018	alpha-Synuclein and phorbol 12-myristate 13-acetate (PMA), which is known to enhance vesicle priming mediated by Rab3A, Munc13-1 and Munc18-1, act on the same population of vesicles, but regulate priming independently.	Tetradecanoylphorbol Acetate	53-56	synuclein alpha	Rattus norvegicus	0-15
8175888-8	1994	The divergent effects of TPA treatment upon cell proliferation and differentiation in different circumstances allow some speculation about a possible role for the ETR101 gene product upon cellular differentiation.	Tetradecanoylphorbol Acetate	25-28	immediate early response 2	Homo sapiens	163-169
8297348-6	1994	Prolonged (48 h) exposure of cells to the phorbol ester phorbol 12-myristate 13-acetate (PMA; 100 nM) resulted in a marked decrease in the amounts of PKC-alpha and PKC-epsilon, with no change in levels of PKC-zeta.	Tetradecanoylphorbol Acetate	89-92	protein kinase C zeta	Homo sapiens	205-213
8055654-0	1994	Inhibitory effect of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NIH3T3 cells.	Tetradecanoylphorbol Acetate	75-106	xanthine dehydrogenase	Mus musculus	33-63
8055654-1	1994	Treatment of NIH3T3 cells with the tumor promoter phorbol-12-myristate-13-acetate (PMA) results within 30 min in a 1.8-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating reactive oxygen species such as superoxide and hydrogen peroxide.	Tetradecanoylphorbol Acetate	50-81	xanthine dehydrogenase	Mus musculus	137-153
8055654-1	1994	Treatment of NIH3T3 cells with the tumor promoter phorbol-12-myristate-13-acetate (PMA) results within 30 min in a 1.8-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating reactive oxygen species such as superoxide and hydrogen peroxide.	Tetradecanoylphorbol Acetate	50-81	xanthine dehydrogenase	Mus musculus	155-157
30093697-0	2018	TPA-023 attenuates subchronic phencyclidine-induced declarative and reversal learning deficits via GABAA receptor agonist mechanism: possible therapeutic target for cognitive deficit in schizophrenia.	Tetradecanoylphorbol Acetate	0-3	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	99-104
8055654-1	1994	Treatment of NIH3T3 cells with the tumor promoter phorbol-12-myristate-13-acetate (PMA) results within 30 min in a 1.8-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating reactive oxygen species such as superoxide and hydrogen peroxide.	Tetradecanoylphorbol Acetate	83-86	xanthine dehydrogenase	Mus musculus	137-153
8055654-1	1994	Treatment of NIH3T3 cells with the tumor promoter phorbol-12-myristate-13-acetate (PMA) results within 30 min in a 1.8-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of generating reactive oxygen species such as superoxide and hydrogen peroxide.	Tetradecanoylphorbol Acetate	83-86	xanthine dehydrogenase	Mus musculus	155-157
8055654-2	1994	Simultaneous administration of 2 and 10 microM curcumin with 100 ng/ml PMA inhibits PMA-induced increases in XO activity measured 30 min later by 22.7% and 36.5%, respectively.	Tetradecanoylphorbol Acetate	71-74	xanthine dehydrogenase	Mus musculus	109-111
8055654-2	1994	Simultaneous administration of 2 and 10 microM curcumin with 100 ng/ml PMA inhibits PMA-induced increases in XO activity measured 30 min later by 22.7% and 36.5%, respectively.	Tetradecanoylphorbol Acetate	84-87	xanthine dehydrogenase	Mus musculus	109-111
8055654-5	1994	Based on these findings, induction of XO activity is deemed to be one of the major causative elements in PMA-mediated tumor promotion, and the major inhibitory mechanism of curcumin on PMA-induced increases in XD/XO enzyme activities is through direct inactivation at the protein level.	Tetradecanoylphorbol Acetate	105-108	xanthine dehydrogenase	Mus musculus	38-40
7507104-8	1994	Exposure to 1 microM TPA for 24 h down-regulated PKC-alpha, -delta, and -epsilon, but not PKC-zeta.	Tetradecanoylphorbol Acetate	21-24	protein kinase C, alpha	Rattus norvegicus	49-80
30093697-11	2018	These results suggest that TPA-023 and other GABAA agonists may be of benefit to treat CIAS.	Tetradecanoylphorbol Acetate	27-30	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	45-50
8056031-4	1994	Stimulation of IL-2R alpha+ and IL-2R alpha- immature thymocytes with phorbol 12-myristate 13-acetate and calcium ionophore induces synthesis of IL-2R alpha and IL-2R beta mRNA.	Tetradecanoylphorbol Acetate	70-101	interleukin 2 receptor, alpha chain	Mus musculus	15-26
30314274-4	2018	Conversely, chronic topical applications of a PAF-R agonist suppressed non-melanoma skin cancer (NMSC) in a topical chemical carcinogenesis model (dimethylbenz[a]anthracene/phorbol 12-myristate 13-acetate (DMBA/PMA)) in-part via anti-inflammatory effects.	Tetradecanoylphorbol Acetate	173-204	platelet-activating factor receptor	Mus musculus	46-51
8056031-4	1994	Stimulation of IL-2R alpha+ and IL-2R alpha- immature thymocytes with phorbol 12-myristate 13-acetate and calcium ionophore induces synthesis of IL-2R alpha and IL-2R beta mRNA.	Tetradecanoylphorbol Acetate	70-101	interleukin 2 receptor, alpha chain	Mus musculus	32-43
8056031-4	1994	Stimulation of IL-2R alpha+ and IL-2R alpha- immature thymocytes with phorbol 12-myristate 13-acetate and calcium ionophore induces synthesis of IL-2R alpha and IL-2R beta mRNA.	Tetradecanoylphorbol Acetate	70-101	interleukin 2 receptor, alpha chain	Mus musculus	32-43
21559587-4	1994	The most effective antioxidant, loblolly pine bark CT, also inhibits TPA-induced ODC activity and macromolecule synthesis to a much greater degree than catechin or the other CTs tested.	Tetradecanoylphorbol Acetate	69-72	ornithine decarboxylase, structural 1	Mus musculus	81-84
7527452-5	1994	Overnight treatment of ANA-1 cells with 100 ng/ml 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) caused the suppression of both PKC activity and LPL-induced TNF alpha mRNA expression.	Tetradecanoylphorbol Acetate	101-104	lipoprotein lipase	Mus musculus	154-157
30314274-4	2018	Conversely, chronic topical applications of a PAF-R agonist suppressed non-melanoma skin cancer (NMSC) in a topical chemical carcinogenesis model (dimethylbenz[a]anthracene/phorbol 12-myristate 13-acetate (DMBA/PMA)) in-part via anti-inflammatory effects.	Tetradecanoylphorbol Acetate	211-214	platelet-activating factor receptor	Mus musculus	46-51
30596378-8	2018	CCL2 was detected in few cluster of differentiation (CD)14+ monocytes in PBMC stimulated with PMA and ionomycin for 2 h. CCL3 was produced by CD14+ monocytes after 4-6 h culture in medium.	Tetradecanoylphorbol Acetate	94-97	C-C motif chemokine 2	Equus caballus	0-4
8035171-4	1994	The action of IL-1 was not mediated by PKC because treatment of cells with maximal concentrations of both IL-1 and TPA gave an additive increase in NGF mRNA content and NGF secretion, and because down-regulating PKC activity failed to inhibit the stimulatory effects of IL-1.	Tetradecanoylphorbol Acetate	115-118	protein kinase C, gamma	Rattus norvegicus	212-215
30596378-12	2018	Culture of PBMC for longer than 6 h or stimulation with PMA and ionomycin reduced the percentage of CCL5+ cells.	Tetradecanoylphorbol Acetate	56-59	C-C motif chemokine 5	Equus caballus	100-104
8035171-6	1994	An analysis of the effects of IL-1 and TPA on immediate early gene expression indicated that IL-1 preferentially induced c-jun gene expression, whereas TPA greatly increased c-fos and zif/268 gene expression.	Tetradecanoylphorbol Acetate	152-155	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	174-179
29559340-0	2018	Epidermal FABP Prevents Chemical-Induced Skin Tumorigenesis by Regulation of TPA-Induced IFN/p53/SOX2 Pathway in Keratinocytes.	Tetradecanoylphorbol Acetate	77-80	SRY (sex determining region Y)-box 2	Mus musculus	97-101
8036019-2	1994	Although S63 and S73 are conserved in the mutant v-Jun oncoprotein, they are not phosphorylated by two enzymes which target the corresponding residues in c-Jun in vitro; namely a partially purified c-Jun kinase from TPA-stimulated U937 cells and purified p54 mitogen activated protein (MAP) kinase.	Tetradecanoylphorbol Acetate	216-219	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	198-203
8036020-5	1994	Following activation of PKC, the effects of TPA are known to act through the transcription factor AP-1.	Tetradecanoylphorbol Acetate	44-47	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-102
8025287-2	1994	Activation of protein kinase C-dependent pathways with phorbol myristate acetate (PMA) or activation of protein kinase A-dependent pathways with DBcAMP and prostaglandin E2 resulted in an augmented IL-4R expression at mRNA and protein level.	Tetradecanoylphorbol Acetate	82-85	interleukin 4 receptor	Homo sapiens	198-203
30245919-9	2018	Induction of miR-155 expression was also observed with anti-CD3/anti-CD28 simulation and phorbol-12-Myristate-13-Acetate (PMA) treatment, and further augmented by calcium inophore and bromocyclic AMP in the latter treatment.	Tetradecanoylphorbol Acetate	89-120	microRNA 155	Homo sapiens	13-20
7525477-4	1994	PMA induced a time-, dose-, and L-arginine-dependent increase in cyclic GMP, which could be inhibited by dexamethasone or actinomycin D.	Tetradecanoylphorbol Acetate	0-3	5'-nucleotidase, cytosolic II	Homo sapiens	72-75
30245919-9	2018	Induction of miR-155 expression was also observed with anti-CD3/anti-CD28 simulation and phorbol-12-Myristate-13-Acetate (PMA) treatment, and further augmented by calcium inophore and bromocyclic AMP in the latter treatment.	Tetradecanoylphorbol Acetate	122-125	microRNA 155	Homo sapiens	13-20
7515859-8	1994	Taken together, our data indicate that PMA induces a rapid and temporary ECM-dependent enhancement of melanoma cell attachment and spreading, and that the response to ECM components appears not to be due to significant shifts in beta 1 integrin expression, but rather to activation of beta 1 integrins.	Tetradecanoylphorbol Acetate	39-42	integrin subunit beta 1	Homo sapiens	285-301
29528516-6	2018	Both the metabotropic glutamate receptor 3 (mGluR3) antagonist Ly341495 and the protein kinase C (PKC) activator phorbol-12-myristate-13-acetate prevented the decrease in melatonin secretion, suggesting that BMAA inhibits melatonin synthesis by mGluR3 activation and PKC inhibition.	Tetradecanoylphorbol Acetate	113-144	glutamate receptor, ionotropic, AMPA3 (alpha 3)	Mus musculus	245-251
8020140-0	1994	Inhibitory effect of silymarin, an anti-hepatotoxic flavonoid, on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice.	Tetradecanoylphorbol Acetate	66-102	ornithine decarboxylase, structural 1	Mus musculus	121-144
8020140-4	1994	Application of silymarin at doses of 0.5-18 mg (1-37 mumol)/mouse prior to that of TPA (2.5 micrograms) treatment resulted in significant inhibition of TPA-induced epidermal ODC activity in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	152-155	ornithine decarboxylase, structural 1	Mus musculus	174-177
30073169-10	2018	In agreement, 80 nM PMA (a PKC activator) mimicked the effect of LPS on the activation of the MEK/ERK/TSC2/mTORC1/S6K pathway, monocyte adhesion to ECV cells and actin cytoskeleton rearrangement.	Tetradecanoylphorbol Acetate	20-23	TSC complex subunit 2	Homo sapiens	102-106
8020140-5	1994	Northern blot analysis revealed that topical application of silymarin at the dose of 2 mg/mouse resulted in almost complete inhibition of TPA-induced epidermal ODC mRNA.	Tetradecanoylphorbol Acetate	138-141	ornithine decarboxylase, structural 1	Mus musculus	160-163
8020141-1	1994	Rapid transient induction of the human c-jun proto-oncogene by 12-O-tetradecanoylphorbol-13-acetate (TPA) and UV irradiation requires the presence of two cis-acting elements, Jun1 and Jun2.	Tetradecanoylphorbol Acetate	63-99	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-44
8020141-1	1994	Rapid transient induction of the human c-jun proto-oncogene by 12-O-tetradecanoylphorbol-13-acetate (TPA) and UV irradiation requires the presence of two cis-acting elements, Jun1 and Jun2.	Tetradecanoylphorbol Acetate	101-104	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-44
29842805-6	2018	The present results showed that the MEF2A and MEF2D function as mediators for TPA-elicited SOD3 expression by interacting with HDAC or p300.	Tetradecanoylphorbol Acetate	78-81	myocyte enhancer factor 2D	Homo sapiens	46-51
8194136-3	1994	We confirmed that N-acetyl-L-cysteine (NAC), a cysteine prodrug which maintains intracellular GSH levels during oxidative stress, inhibits in the chronically infected U1 cells, the stimulation of HIV replication induced by phorbol 12-myristate 13-acetate (PMA), interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF).	Tetradecanoylphorbol Acetate	223-254	X-linked Kx blood group	Homo sapiens	39-42
8200037-3	1994	In the present report, we describe a CD30 mAb, termed BY88, that was capable of inducing, in a short-term assay, a strong proliferation of the T cell clone DS6 when added in combination with IL2 or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	198-223	TNF receptor superfamily member 8	Homo sapiens	37-41
29630947-3	2018	At non-lethal concentrations, the compounds suppressed in vitro migration of MDA-MB-231 breast carcinoma cells, which was correlated with a dose-dependent downregulation of phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) expression and secretion.	Tetradecanoylphorbol Acetate	173-204	matrix metallopeptidase 9	Homo sapiens	247-252
8201967-2	1994	Relative to CHO R cells, CHO Y2 cells exhibited a marked decrease in their response to insulin and 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) for hIR phosphorylation on serine residues.	Tetradecanoylphorbol Acetate	150-153	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	159-162
8201967-4	1994	Finally, in contrast to CHO R cells, CHO Y2 cells were refractory to PMA-induced IR desensitization for subsequent activation by insulin of exogenous tyrosine kinase and glycogen synthesis.	Tetradecanoylphorbol Acetate	69-72	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	81-83
8201967-5	1994	These results strongly suggest that the replacement of tyrosines 1162 and 1163 by phenylalanine residues changes the IR beta-subunit conformation and thus impedes phosphorylation of the IR at crucial serine residues and prevents PMA-induced desensitization.	Tetradecanoylphorbol Acetate	229-232	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	117-119
8201967-5	1994	These results strongly suggest that the replacement of tyrosines 1162 and 1163 by phenylalanine residues changes the IR beta-subunit conformation and thus impedes phosphorylation of the IR at crucial serine residues and prevents PMA-induced desensitization.	Tetradecanoylphorbol Acetate	229-232	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	186-188
29630947-3	2018	At non-lethal concentrations, the compounds suppressed in vitro migration of MDA-MB-231 breast carcinoma cells, which was correlated with a dose-dependent downregulation of phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) expression and secretion.	Tetradecanoylphorbol Acetate	206-209	matrix metallopeptidase 9	Homo sapiens	247-252
29748238-5	2018	Moreover, the expression of miR-302e was significantly decreased in response to phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 or ovalbumin (OVA) stimulation.	Tetradecanoylphorbol Acetate	80-111	microRNA 302e	Homo sapiens	28-36
29748238-5	2018	Moreover, the expression of miR-302e was significantly decreased in response to phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 or ovalbumin (OVA) stimulation.	Tetradecanoylphorbol Acetate	113-116	microRNA 302e	Homo sapiens	28-36
7910166-3	1994	Here, we have developed stable GC-A transfectants of NIH3T3 cells, which display marked reductions in hormone-dependent cGMP elevations and guanylyl cyclase activity after incubation with ANP or phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	195-226	natriuretic peptide receptor 1	Mus musculus	31-35
29477140-6	2018	Furthermore, we found that treatment with the KDM6B inhibitor GSK-J4 perturbed the PMA-mediated differentiation of THP-1 cells.	Tetradecanoylphorbol Acetate	83-86	lysine demethylase 6B	Homo sapiens	46-51
7910166-7	1994	The specific PKC inhibitor, GF-109203X, completely blocked the PMA-dependent dephosphorylation and desensitization of GC-A but failed to inhibit either ANP-dependent process.	Tetradecanoylphorbol Acetate	63-66	natriuretic peptide receptor 1	Mus musculus	118-122
8187876-0	1994	Antipeptide antibodies directed against the C-terminus of protein kinase C zeta (PKC zeta) react with a Ca(2+)- and TPA-sensitive PKC in HT-29 human intestinal epithelial cells.	Tetradecanoylphorbol Acetate	116-119	protein kinase C zeta	Homo sapiens	58-79
8187876-0	1994	Antipeptide antibodies directed against the C-terminus of protein kinase C zeta (PKC zeta) react with a Ca(2+)- and TPA-sensitive PKC in HT-29 human intestinal epithelial cells.	Tetradecanoylphorbol Acetate	116-119	protein kinase C zeta	Homo sapiens	81-89
29725176-1	2018	Background: The effect of intravenous tissue plasminogen activator (IV tPA) administration before endovascular intervention as compared to without at thrombectomy-capable low-volume centers on procedural aspects and patient outcomes has not been investigated.	Tetradecanoylphorbol Acetate	71-74	chromosome 20 open reading frame 181	Homo sapiens	38-66
8187876-0	1994	Antipeptide antibodies directed against the C-terminus of protein kinase C zeta (PKC zeta) react with a Ca(2+)- and TPA-sensitive PKC in HT-29 human intestinal epithelial cells.	Tetradecanoylphorbol Acetate	116-119	protein kinase C zeta	Homo sapiens	81-84
8187876-1	1994	We have studied the PKC isoforms present in HT-29 M6 colon cancer cells, the differentiation of which to mucus-secreting cells is blocked by TPA.	Tetradecanoylphorbol Acetate	141-144	protein kinase C zeta	Homo sapiens	20-23
8187876-2	1994	In addition to a major 72 kDa band, a 77 kDa PKC isoform was recognized by two different antibodies raised against a C-terminus-specific peptide for the TPA-insensitive isoform, PKC zeta.	Tetradecanoylphorbol Acetate	153-156	protein kinase C zeta	Homo sapiens	45-48
8187876-2	1994	In addition to a major 72 kDa band, a 77 kDa PKC isoform was recognized by two different antibodies raised against a C-terminus-specific peptide for the TPA-insensitive isoform, PKC zeta.	Tetradecanoylphorbol Acetate	153-156	protein kinase C zeta	Homo sapiens	178-186
8194525-1	1994	Modulation of gene expression by 12-O-tetradecanoylphorbol-13-acetate (TPA) is thought to be mediated by protein kinase C (PKC), a major cellular receptor for TPA.	Tetradecanoylphorbol Acetate	33-69	protein kinase C, delta	Mus musculus	123-126
8194525-1	1994	Modulation of gene expression by 12-O-tetradecanoylphorbol-13-acetate (TPA) is thought to be mediated by protein kinase C (PKC), a major cellular receptor for TPA.	Tetradecanoylphorbol Acetate	71-74	protein kinase C, delta	Mus musculus	123-126
8194525-1	1994	Modulation of gene expression by 12-O-tetradecanoylphorbol-13-acetate (TPA) is thought to be mediated by protein kinase C (PKC), a major cellular receptor for TPA.	Tetradecanoylphorbol Acetate	159-162	protein kinase C, delta	Mus musculus	123-126
8194525-2	1994	We confirm this by showing that the overexpression of PKC delta enhances the TPA induction of the TRE-tk-CAT reporter gene in NIH3T3 cells.	Tetradecanoylphorbol Acetate	77-80	protein kinase C, delta	Mus musculus	54-63
7917514-2	1994	Secretion of IL-2 and TNF-alpha, surface expression of IL-2R, and DNA-binding activity of NF-kappa B and AP-1 (Fos/Jun) complex in response to phorbol myristate acetate, TNF-alpha, or immobilized antibodies to CD3 were monitored.	Tetradecanoylphorbol Acetate	143-168	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	111-114
8200063-5	1994	Intraperitoneal injection of recombinant (r) GM-CSF into SENCAR mice at 2 h prior to topical application of 10 micrograms TPA induced a significant increase in epidermal keratinocyte proliferation, leukocyte infiltration into the dermis, hydroperoxide production by circulating neutrophils and chemotactic activity present within the plasma at 24 h compared to treatment with only 10 micrograms TPA.	Tetradecanoylphorbol Acetate	122-125	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	45-51
8200063-5	1994	Intraperitoneal injection of recombinant (r) GM-CSF into SENCAR mice at 2 h prior to topical application of 10 micrograms TPA induced a significant increase in epidermal keratinocyte proliferation, leukocyte infiltration into the dermis, hydroperoxide production by circulating neutrophils and chemotactic activity present within the plasma at 24 h compared to treatment with only 10 micrograms TPA.	Tetradecanoylphorbol Acetate	395-398	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	45-51
8200063-6	1994	Intravenous injection of anti-GM-CSF antibodies significantly inhibited both local and systemic inflammatory events induced by topical application of TPA.	Tetradecanoylphorbol Acetate	150-153	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	30-36
8179594-1	1994	The transcription factor AP-1 is an important human mediator of the cellular response to serum, growth factors, and phorbol esters such as 12-O-tetradecanoyl-phorbol-13 acetate (TPA).	Tetradecanoylphorbol Acetate	139-176	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-29
8179594-1	1994	The transcription factor AP-1 is an important human mediator of the cellular response to serum, growth factors, and phorbol esters such as 12-O-tetradecanoyl-phorbol-13 acetate (TPA).	Tetradecanoylphorbol Acetate	178-181	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-29
8179594-2	1994	The AP-1 complex consists of distinct protein heterodimers encoded by the proto-oncogene c-fos and c-jun mRNA whose gene expression can be induced by TPA, cyclic AMP and growth factors.	Tetradecanoylphorbol Acetate	150-153	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-8
8179594-2	1994	The AP-1 complex consists of distinct protein heterodimers encoded by the proto-oncogene c-fos and c-jun mRNA whose gene expression can be induced by TPA, cyclic AMP and growth factors.	Tetradecanoylphorbol Acetate	150-153	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-94
8179594-2	1994	The AP-1 complex consists of distinct protein heterodimers encoded by the proto-oncogene c-fos and c-jun mRNA whose gene expression can be induced by TPA, cyclic AMP and growth factors.	Tetradecanoylphorbol Acetate	150-153	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	99-104
8179594-3	1994	Recent findings suggest an involvement of reactive oxygen species in the pathway of TPA and protein kinase C leading to expression of c-fos and c-jun mRNA.	Tetradecanoylphorbol Acetate	84-87	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-139
8179594-3	1994	Recent findings suggest an involvement of reactive oxygen species in the pathway of TPA and protein kinase C leading to expression of c-fos and c-jun mRNA.	Tetradecanoylphorbol Acetate	84-87	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	144-149
8179594-5	1994	When cells were preincubated with dihydrolipoic acid (0.2 mM) the expression of c-fos mRNA was suppressed at 30 min after stimulation of TPA (0.5 microM) whereas in the case of preincubation of alpha-lipoic acid (0.2 microM), the expression was enhanced at 30 min.	Tetradecanoylphorbol Acetate	137-140	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-85
7519562-1	1994	We examined the mechanisms involved in the activation of atrial natriuretic peptide (ANP) gene expression and secretion in response to acidic fibroblast growth factor (aFGF) by studying the effects of staurosporine, a protein kinase C inhibitor, and 12-O-tetradecanoyl phorbol 13-acetate (TPA), an activator of protein kinase C, on basal and AFGF-induced ANP messenger RNA (mRNA) and immunoreactive ANP (IR-ANP) levels in cultured neonatal rat cardiac myocytes.	Tetradecanoylphorbol Acetate	250-287	fibroblast growth factor 1	Rattus norvegicus	168-172
7519562-1	1994	We examined the mechanisms involved in the activation of atrial natriuretic peptide (ANP) gene expression and secretion in response to acidic fibroblast growth factor (aFGF) by studying the effects of staurosporine, a protein kinase C inhibitor, and 12-O-tetradecanoyl phorbol 13-acetate (TPA), an activator of protein kinase C, on basal and AFGF-induced ANP messenger RNA (mRNA) and immunoreactive ANP (IR-ANP) levels in cultured neonatal rat cardiac myocytes.	Tetradecanoylphorbol Acetate	289-292	natriuretic peptide A	Rattus norvegicus	57-83
7519562-1	1994	We examined the mechanisms involved in the activation of atrial natriuretic peptide (ANP) gene expression and secretion in response to acidic fibroblast growth factor (aFGF) by studying the effects of staurosporine, a protein kinase C inhibitor, and 12-O-tetradecanoyl phorbol 13-acetate (TPA), an activator of protein kinase C, on basal and AFGF-induced ANP messenger RNA (mRNA) and immunoreactive ANP (IR-ANP) levels in cultured neonatal rat cardiac myocytes.	Tetradecanoylphorbol Acetate	289-292	natriuretic peptide A	Rattus norvegicus	85-88
7519562-1	1994	We examined the mechanisms involved in the activation of atrial natriuretic peptide (ANP) gene expression and secretion in response to acidic fibroblast growth factor (aFGF) by studying the effects of staurosporine, a protein kinase C inhibitor, and 12-O-tetradecanoyl phorbol 13-acetate (TPA), an activator of protein kinase C, on basal and AFGF-induced ANP messenger RNA (mRNA) and immunoreactive ANP (IR-ANP) levels in cultured neonatal rat cardiac myocytes.	Tetradecanoylphorbol Acetate	289-292	fibroblast growth factor 1	Rattus norvegicus	168-172
7519562-6	1994	TPA (100 nM) alone significantly stimulated ANP gene expression and secretion but these effects were not augmented by combining aFGF with TPA.	Tetradecanoylphorbol Acetate	0-3	natriuretic peptide A	Rattus norvegicus	44-47
8144669-7	1994	In addition, we show that protein kinase C (PKC) also undergoes an extensive redistribution to the Triton X-100-insoluble fraction in 4 beta-phorbol 12-myristate 13-acetate-stimulated cells, the extent of which is diminished significantly in neutrophils from chronic granulomatous disease patients who lack either p47-phox or cytochrome b558.	Tetradecanoylphorbol Acetate	136-172	neutrophil cytosolic factor 1	Homo sapiens	314-322
8144669-7	1994	In addition, we show that protein kinase C (PKC) also undergoes an extensive redistribution to the Triton X-100-insoluble fraction in 4 beta-phorbol 12-myristate 13-acetate-stimulated cells, the extent of which is diminished significantly in neutrophils from chronic granulomatous disease patients who lack either p47-phox or cytochrome b558.	Tetradecanoylphorbol Acetate	136-172	mitochondrially encoded cytochrome b	Homo sapiens	326-338
8149476-4	1994	Both single and multiple applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in accumulation of GM-CSF mRNA in the epidermis.	Tetradecanoylphorbol Acetate	41-77	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	112-118
8149476-4	1994	Both single and multiple applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in accumulation of GM-CSF mRNA in the epidermis.	Tetradecanoylphorbol Acetate	79-82	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	112-118
8149476-7	1994	The retinoic acid analogue RO-109359 which, unlike RA, does not have tumor promoting activity per se, inhibited the TPA-induced increase in epidermal GM-CSF mRNA levels.	Tetradecanoylphorbol Acetate	116-119	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	150-156
8149476-8	1994	When an antibody specific to GM-CSF was administered prior to TPA, the promoter-induced dermal inflammation and increase in epidermal dark cell number were reduced, yet promoter-induced epidermal hyperplasia was not.	Tetradecanoylphorbol Acetate	62-65	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	29-35
8149483-0	1994	Retinoic acid nuclear receptors and tumor promotion: decreased expression of retinoic acid nuclear receptors by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	131-167	retinoic acid receptor, alpha	Mus musculus	0-31
8149483-0	1994	Retinoic acid nuclear receptors and tumor promotion: decreased expression of retinoic acid nuclear receptors by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	131-167	retinoic acid receptor, alpha	Mus musculus	77-108
8149483-1	1994	During studies to determine the mechanism of tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA), we found that TPA downregulates mouse epidermal retinoic acid nuclear receptors (RAR), a superfamily of nuclear steroid/thyroid receptors implicated in mediating effects of retinoic acid (RA).	Tetradecanoylphorbol Acetate	64-100	retinoic acid receptor, alpha	Mus musculus	156-187
8149483-1	1994	During studies to determine the mechanism of tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA), we found that TPA downregulates mouse epidermal retinoic acid nuclear receptors (RAR), a superfamily of nuclear steroid/thyroid receptors implicated in mediating effects of retinoic acid (RA).	Tetradecanoylphorbol Acetate	64-100	retinoic acid receptor, alpha	Mus musculus	189-192
8030434-2	1994	Using this assay system, we examined the effect of phorbol myristate acetate (PMA) on osteoclast formation as assessed by the appearance of tartrate-resistant acid phosphatase (TRAP)-positive cells and bone resorption lacunae.	Tetradecanoylphorbol Acetate	78-81	acid phosphatase 5, tartrate resistant	Mus musculus	140-175
8139561-10	1994	Stimulation with tetradecanoyl phorbol acetate (TPA) resulted in the nuclear translocation of both NF-kappa B and c-Rel-p65 (RelA) in HeLa cells and of NF-kappa B in HepG2 cells but had no effect on either complex in K562 cells.	Tetradecanoylphorbol Acetate	17-46	REL proto-oncogene, NF-kB subunit	Homo sapiens	114-119
8139561-10	1994	Stimulation with tetradecanoyl phorbol acetate (TPA) resulted in the nuclear translocation of both NF-kappa B and c-Rel-p65 (RelA) in HeLa cells and of NF-kappa B in HepG2 cells but had no effect on either complex in K562 cells.	Tetradecanoylphorbol Acetate	48-51	REL proto-oncogene, NF-kB subunit	Homo sapiens	114-119
8139561-11	1994	In addition, TPA stimulation of HepG2 cells induced the expression of a cytosolic latent c-Rel-p65 (RelA) complex which, however, was not translocated to the nucleus.	Tetradecanoylphorbol Acetate	13-16	REL proto-oncogene, NF-kB subunit	Homo sapiens	89-94
8119191-0	1994	1,25-Dihydroxyvitamin D3 and phorbol myristate acetate synergistically increase carbonic anhydrase-II expression in a human myelomonocytic cell line.	Tetradecanoylphorbol Acetate	29-54	carbonic anhydrase 2	Homo sapiens	80-101
8119191-4	1994	Both 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3; 10 nM] and phorbol myristate acetate (10 ng/ml), doses that cause monocytic differentiation of the HL-60 cell, induced small increases in CA-II mRNA and CA-II protein, as measured by Northern analysis and Western immunoblotting, respectively.	Tetradecanoylphorbol Acetate	56-81	carbonic anhydrase 2	Homo sapiens	183-188
8119191-4	1994	Both 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3; 10 nM] and phorbol myristate acetate (10 ng/ml), doses that cause monocytic differentiation of the HL-60 cell, induced small increases in CA-II mRNA and CA-II protein, as measured by Northern analysis and Western immunoblotting, respectively.	Tetradecanoylphorbol Acetate	56-81	carbonic anhydrase 2	Homo sapiens	198-203
8119191-7	1994	The large increase in CA-II mRNA allowed assessment of the dose dependence of both agents, with ED50 values of 1 nM for 1,25-(OH)2D3 and 1 ng/ml for phorbol myristate acetate.	Tetradecanoylphorbol Acetate	149-174	carbonic anhydrase 2	Homo sapiens	22-27
7510235-6	1994	These similarities are extended to show that culturing of lpr CD4-CD8- T cells in the presence of IL-2 in combination with phorbol 12-myristate 13-acetate and ionomycin initiates cell cycling and results in the gain of function; re-stimulation now yields IL-2-dependent proliferation in the absence of exogenous IL-2.	Tetradecanoylphorbol Acetate	123-154	CD4 antigen	Mus musculus	62-65
7510294-8	1994	The level of IGFBP-2 mRNA in the cells was increased by TPA, indicating that the increase in IGFBP-2 secretion results from the stimulation of IGFBP-2 production.	Tetradecanoylphorbol Acetate	56-59	insulin-like growth factor binding protein 2	Mus musculus	13-20
7510294-8	1994	The level of IGFBP-2 mRNA in the cells was increased by TPA, indicating that the increase in IGFBP-2 secretion results from the stimulation of IGFBP-2 production.	Tetradecanoylphorbol Acetate	56-59	insulin-like growth factor binding protein 2	Mus musculus	93-100
7510294-8	1994	The level of IGFBP-2 mRNA in the cells was increased by TPA, indicating that the increase in IGFBP-2 secretion results from the stimulation of IGFBP-2 production.	Tetradecanoylphorbol Acetate	56-59	insulin-like growth factor binding protein 2	Mus musculus	93-100
8114743-5	1994	We demonstrate that tetradecanoyl phorbol acetate treatment results in a marked and prolonged increase in AP-1 binding activity on these elements, which can be accounted for almost entirely by c-jun and junB.	Tetradecanoylphorbol Acetate	20-49	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	193-198
7906937-6	1994	The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 showed almost complete inhibition of the increase in intracellular peroxide levels of the endothelial cells exposed to PMA-stimulated leukocytes.	Tetradecanoylphorbol Acetate	184-187	integrin subunit alpha M	Homo sapiens	41-46
8106362-7	1994	In MDBK cells, the phorbol ester 12-0-tetradecanoylphorbol-13-acetate (TPA) (100 nM, 24 h) down-regulates PKC alpha and, to a lesser extent, PKC zeta, without altering their subcellular distribution.	Tetradecanoylphorbol Acetate	71-74	protein kinase C alpha	Bos taurus	106-115
8180129-9	1994	A 72-h treatment with one nM TPA maximally increased expression of c-jun, krox-24, and jun-B mRNA transcripts.	Tetradecanoylphorbol Acetate	29-32	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	67-72
8289787-4	1994	Ablation of epidermal growth factor-, tetradecanoyl phorbol acetate-, or anisomycin-stimulated S6 phosphorylation by using the p70/85S6k inhibitor rapamycin has no effect on histone H3 and HMG-like protein phosphorylation or on the induction and superinduction of c-fos and c-jun.	Tetradecanoylphorbol Acetate	38-67	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	264-269
8289787-4	1994	Ablation of epidermal growth factor-, tetradecanoyl phorbol acetate-, or anisomycin-stimulated S6 phosphorylation by using the p70/85S6k inhibitor rapamycin has no effect on histone H3 and HMG-like protein phosphorylation or on the induction and superinduction of c-fos and c-jun.	Tetradecanoylphorbol Acetate	38-67	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	274-279
8123590-3	1994	Functional AP-1 activity was demonstrated in differentiating SH-SY5Y cells by transient transfection assays using a TPA-responsive reporter plasmid.	Tetradecanoylphorbol Acetate	116-119	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	11-15
8288587-2	1994	Recently, 12-O-tetradecanoylphorbol 13-acetate has been found to mediate Raf-1 phosphorylation, suggesting that protein kinase C (PKC) may be involved in the Raf-1 activation mechanism(s).	Tetradecanoylphorbol Acetate	10-46	v-raf-leukemia viral oncogene 1	Mus musculus	73-78
8288587-2	1994	Recently, 12-O-tetradecanoylphorbol 13-acetate has been found to mediate Raf-1 phosphorylation, suggesting that protein kinase C (PKC) may be involved in the Raf-1 activation mechanism(s).	Tetradecanoylphorbol Acetate	10-46	v-raf-leukemia viral oncogene 1	Mus musculus	158-163
8288641-7	1994	Treatment of HL-60, but not HL-525, cells with TPA was associated with increased MAP kinase activity as determined by phosphorylation of myelin basic protein and the c-Jun Y peptide.	Tetradecanoylphorbol Acetate	47-50	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	166-171
8276849-4	1994	The mitogenic responses of PKA and PDE mutants to insulin, epidermal growth factor, or 12-O-tetradecanoylphorbol-13-acetate were not significantly changed.	Tetradecanoylphorbol Acetate	87-123	mitogen-activated protein kinase kinase kinase 14	Mus musculus	27-30
7942278-2	1994	Expression of Ha-ras by dexamethasone leads to a transcriptional activation of the fos-CAT construct which was found to be sensitive to the PKC inhibitor ilmofosine (BM41440) and abrogated by PKC depletion following long-term exposure to TPA.	Tetradecanoylphorbol Acetate	238-241	Harvey rat sarcoma virus oncogene	Mus musculus	14-20
7942278-5	1994	Transcriptional activation of the SRE-FAP-TK-CAT as well as the SRE-TK-CAT constructs by Ha-ras is sensitive to the PKC-inhibitor ilmofosine (BM41440) and blocked by long-term exposure to TPA.	Tetradecanoylphorbol Acetate	188-191	Harvey rat sarcoma virus oncogene	Mus musculus	89-95
8123590-7	1994	In addition, TPA-mediated induction of AP-2 DNA binding activity to the NPY promoter was not dependent on increased AP-2 mRNA expression.	Tetradecanoylphorbol Acetate	13-16	transcription factor AP-2 alpha	Homo sapiens	39-43
8137877-6	1994	Application of phorbol 12-myristate 13-acetate also depressed the Ca2+ channel current, but this phorbol ester-induced depression was not additive to that induced by interleukin-1 beta.	Tetradecanoylphorbol Acetate	15-46	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	66-69
7879317-2	1994	ICAM-1 antigen expression was induced on CaKi-1 cells by incubation with either phorbol-12-myristate 13 acetate (PMA) or interferon-gamma (IFN-gamma).	Tetradecanoylphorbol Acetate	80-111	intercellular adhesion molecule 1	Homo sapiens	0-6
7879317-2	1994	ICAM-1 antigen expression was induced on CaKi-1 cells by incubation with either phorbol-12-myristate 13 acetate (PMA) or interferon-gamma (IFN-gamma).	Tetradecanoylphorbol Acetate	113-116	intercellular adhesion molecule 1	Homo sapiens	0-6
8257426-2	1993	Evidence has been accumulated that in phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, the translocation to the plasma membrane of the cytosolic components p47phox and p67phox and the phosphorylation of p47phox are essential steps in activation of NADPH oxidase.	Tetradecanoylphorbol Acetate	38-69	neutrophil cytosolic factor 1	Homo sapiens	169-176
8112504-8	1993	PAF-induced contraction was significantly reduced by treatment with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	68-99	PCNA clamp associated factor	Rattus norvegicus	0-3
8112504-8	1993	PAF-induced contraction was significantly reduced by treatment with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	101-104	PCNA clamp associated factor	Rattus norvegicus	0-3
7505837-3	1993	The phorbol ester phorbol-12-myristoyl-13-acetate (PMA) did not affect biosynthesis of the protein backbone, but enhanced incorporation of phosphate by a factor of 2-3, indicating the involvement of protein kinase C. Exclusive phosphorylation of serine residues was also observed, when purified MAG was incubated with protein kinase C in the presence of [gamma-32P]ATP.	Tetradecanoylphorbol Acetate	51-54	myelin associated glycoprotein	Homo sapiens	295-298
8107331-1	1993	The effects of L-nitro-arginine (LNAG) and phorbol myristate acetate (PMA) were studied in bradykinin-induced relaxations in bovine coronary arteries.	Tetradecanoylphorbol Acetate	43-68	kininogen 1	Bos taurus	91-101
8107331-1	1993	The effects of L-nitro-arginine (LNAG) and phorbol myristate acetate (PMA) were studied in bradykinin-induced relaxations in bovine coronary arteries.	Tetradecanoylphorbol Acetate	70-73	kininogen 1	Bos taurus	91-101
8134292-6	1993	Staurosporine, an inhibitor of protein kinase C, totally abolished the basal as well as the gastrin-stimulated activity of protein kinase C. The tumor promoter phorbol 12-myristate 13-acetate also stimulated colonic epithelial protein kinase C. However, prolonged treatment of cells with phorbol inhibited their subsequent response to gastrin stimulation.	Tetradecanoylphorbol Acetate	160-191	gastrin	Rattus norvegicus	92-99
8134292-6	1993	Staurosporine, an inhibitor of protein kinase C, totally abolished the basal as well as the gastrin-stimulated activity of protein kinase C. The tumor promoter phorbol 12-myristate 13-acetate also stimulated colonic epithelial protein kinase C. However, prolonged treatment of cells with phorbol inhibited their subsequent response to gastrin stimulation.	Tetradecanoylphorbol Acetate	160-191	gastrin	Rattus norvegicus	335-342
8405436-4	1993	Exposure of the cells to 100 nM TPA for 10 min resulted in the translocation of conventional PKC alpha (cPKC alpha) and new PKC delta (nPKC delta) and -epsilon from the cytosolic to the membrane fraction, while left atypical PKC zeta (aPKC zeta) unaffected.	Tetradecanoylphorbol Acetate	32-35	protein kinase C zeta	Homo sapiens	225-233
8407934-6	1993	After activation of neutrophils with phorbol 12-myristate 13-acetate or formyl-methionyl-leucyl-phenylalanine, Rac was translocated from the cytosol to the plasma membrane, and this translocation corresponded temporally with the translocation of p47-phox and p67-phox and with the generation of superoxide.	Tetradecanoylphorbol Acetate	37-68	neutrophil cytosolic factor 1	Homo sapiens	246-254
8287040-2	1993	12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophorin A) and myelocytic (CD11b) antigens in K562-L, but increased the expression of these antigens in K562-H. TPA increased the megakaryocytic (CD61) antigens in both cells.	Tetradecanoylphorbol Acetate	0-37	integrin subunit alpha M	Homo sapiens	122-127
8287040-2	1993	12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophorin A) and myelocytic (CD11b) antigens in K562-L, but increased the expression of these antigens in K562-H. TPA increased the megakaryocytic (CD61) antigens in both cells.	Tetradecanoylphorbol Acetate	39-42	integrin subunit alpha M	Homo sapiens	122-127
8223588-9	1993	After exposure to phorbol 12-myristate 13-acetate, a complete depletion of PKC-beta was observed within 1 h and the complete depletion of PKC-alpha and PKC-delta isotypes was observed within 4 h. In contrast, PKC-epsilon was only partially down-regulated after a 24-h treatment with phorbol 12-myristate 13-acetate and PKC-zeta was not affected at all.	Tetradecanoylphorbol Acetate	283-314	protein kinase C, delta	Mus musculus	152-161
8409525-1	1993	In a previous paper, we have shown that bradykinin (Bk) and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulate arachidonic acid release from HEL-30 keratinocytes along a Bk-B2 receptor G-protein-coupled pathway or a protein kinase C-dependent mechanism, respectively.	Tetradecanoylphorbol Acetate	116-119	crystallin lambda 1	Homo sapiens	161-167
8409755-5	1993	Treatment of macrophages with 4 beta-phorbol 12-myristate 13-acetate causes a rapid increase in the phosphorylation and a 1.4-1.8-fold increase in the activity of the 85-kd arachidonate-mobilizing phospholipase A2 as determined in an in vitro assay.	Tetradecanoylphorbol Acetate	30-68	phospholipase A2, group IB, pancreas	Mus musculus	197-213
8415663-3	1993	Although both exchangers were stimulated by serum, NHE3 was inhibited by phorbol 12-myristate 13-acetate (PMA), which stimulated NHE1.	Tetradecanoylphorbol Acetate	73-104	solute carrier family 9 member A3	Homo sapiens	51-55
8415663-3	1993	Although both exchangers were stimulated by serum, NHE3 was inhibited by phorbol 12-myristate 13-acetate (PMA), which stimulated NHE1.	Tetradecanoylphorbol Acetate	106-109	solute carrier family 9 member A3	Homo sapiens	51-55
8415663-5	1993	In contrast, serum stimulated and PMA inhibited NHE3 by a Vmax change.	Tetradecanoylphorbol Acetate	34-37	solute carrier family 9 member A3	Homo sapiens	48-52
8395530-4	1993	Pretreatment of the cells with TPA (10(-7) M) abolished the subsequent response to IL-1 beta, TGF-alpha, and EGF and at the same time resulted in &gt; 90% reduction of cytosolic protein kinase C activity.	Tetradecanoylphorbol Acetate	31-34	transforming growth factor alpha	Rattus norvegicus	94-103
8204956-1	1993	Jun and Fos are major components of the transcriptional complex AP-1 (Activator Protein-1), a collection of dimeric transcriptional activators composed of members of the Jun and Fos family of bZIP proteins, that bind to a common site known as TRE (TPA Responsive Element) or the AP-1 site.	Tetradecanoylphorbol Acetate	248-251	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	8-11
8204956-1	1993	Jun and Fos are major components of the transcriptional complex AP-1 (Activator Protein-1), a collection of dimeric transcriptional activators composed of members of the Jun and Fos family of bZIP proteins, that bind to a common site known as TRE (TPA Responsive Element) or the AP-1 site.	Tetradecanoylphorbol Acetate	248-251	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	64-68
8204956-1	1993	Jun and Fos are major components of the transcriptional complex AP-1 (Activator Protein-1), a collection of dimeric transcriptional activators composed of members of the Jun and Fos family of bZIP proteins, that bind to a common site known as TRE (TPA Responsive Element) or the AP-1 site.	Tetradecanoylphorbol Acetate	248-251	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	70-89
8204956-1	1993	Jun and Fos are major components of the transcriptional complex AP-1 (Activator Protein-1), a collection of dimeric transcriptional activators composed of members of the Jun and Fos family of bZIP proteins, that bind to a common site known as TRE (TPA Responsive Element) or the AP-1 site.	Tetradecanoylphorbol Acetate	248-251	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-181
8204956-1	1993	Jun and Fos are major components of the transcriptional complex AP-1 (Activator Protein-1), a collection of dimeric transcriptional activators composed of members of the Jun and Fos family of bZIP proteins, that bind to a common site known as TRE (TPA Responsive Element) or the AP-1 site.	Tetradecanoylphorbol Acetate	248-251	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	279-283
8204956-2	1993	Transcription of c-jun is rapidly induced by exposure to different extra-cellular signals like growth factors, cytokines, tumor promoters (TPA), UV and other DNA-damaging agents.	Tetradecanoylphorbol Acetate	139-142	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-22
8376598-6	1993	Stimulation with PMA or Ionomycin resulted in full translocation of Mac-1 from secretory vesicles and gelatinase granules to the plasma membrane, and partial translocation of Mac-1 from specific granules.	Tetradecanoylphorbol Acetate	17-20	integrin subunit alpha M	Homo sapiens	68-73
8376598-6	1993	Stimulation with PMA or Ionomycin resulted in full translocation of Mac-1 from secretory vesicles and gelatinase granules to the plasma membrane, and partial translocation of Mac-1 from specific granules.	Tetradecanoylphorbol Acetate	17-20	integrin subunit alpha M	Homo sapiens	175-180
8103067-3	1993	Anti-CD3-activated CD8+ T cells did not express gp39; however, CD8+ T cells activated with PMA/ionomycin expressed gp39.	Tetradecanoylphorbol Acetate	91-94	CD8a molecule	Homo sapiens	63-66
8361757-7	1993	As transformation by Ras depends on jun-mediated transcriptional events, we also examined H-ras and c-raf-1 cooperation in transcriptional transactivation of TPA-responsive element (TRE)-dependent reporters.	Tetradecanoylphorbol Acetate	158-161	v-raf-leukemia viral oncogene 1	Mus musculus	100-107
8397306-7	1993	The concomitant administration of homocatechol (10(-4) M) and PMA (10(-8) - 10(-6) M) evoked a drastic and prolonged increase in the NGF mRNA level, and also markedly increased the amounts of NGF secreted by the cells (approximately 150-fold).	Tetradecanoylphorbol Acetate	62-65	nerve growth factor	Mus musculus	133-136
8397306-7	1993	The concomitant administration of homocatechol (10(-4) M) and PMA (10(-8) - 10(-6) M) evoked a drastic and prolonged increase in the NGF mRNA level, and also markedly increased the amounts of NGF secreted by the cells (approximately 150-fold).	Tetradecanoylphorbol Acetate	62-65	nerve growth factor	Mus musculus	192-195
8395972-6	1993	The tumor promoters, butylated hydroxytoluene (BHT), 12-O-tetradecanoylphorbol-13-acetate (TPA), and p,p"-dichlorodiphenyltrichloroethane (DDT), inhibited dye-coupling in C10 cells but phenobarbital (PB) did not.	Tetradecanoylphorbol Acetate	53-89	gene rich cluster, C10 gene	Mus musculus	171-174
8321321-1	1993	The kinase Raf-1 can be activated by treatment of cells with mitogens and by the protein kinase C (PKC) activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) (reviewed in refs 1,2).	Tetradecanoylphorbol Acetate	114-151	v-raf-leukemia viral oncogene 1	Mus musculus	11-16
8321321-1	1993	The kinase Raf-1 can be activated by treatment of cells with mitogens and by the protein kinase C (PKC) activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) (reviewed in refs 1,2).	Tetradecanoylphorbol Acetate	153-156	v-raf-leukemia viral oncogene 1	Mus musculus	11-16
8323287-1	1993	Previous studies from our laboratory suggested that phorbol 12-myristate 13-acetate (TPA) stimulates prostaglandin E2 (PGE2) production by inducing de novo synthesis of prostaglandin H synthase (PHS) in a rat tracheal cell line.	Tetradecanoylphorbol Acetate	52-83	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	169-193
8323287-1	1993	Previous studies from our laboratory suggested that phorbol 12-myristate 13-acetate (TPA) stimulates prostaglandin E2 (PGE2) production by inducing de novo synthesis of prostaglandin H synthase (PHS) in a rat tracheal cell line.	Tetradecanoylphorbol Acetate	52-83	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	195-198
8323287-1	1993	Previous studies from our laboratory suggested that phorbol 12-myristate 13-acetate (TPA) stimulates prostaglandin E2 (PGE2) production by inducing de novo synthesis of prostaglandin H synthase (PHS) in a rat tracheal cell line.	Tetradecanoylphorbol Acetate	85-88	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	169-193
8323287-1	1993	Previous studies from our laboratory suggested that phorbol 12-myristate 13-acetate (TPA) stimulates prostaglandin E2 (PGE2) production by inducing de novo synthesis of prostaglandin H synthase (PHS) in a rat tracheal cell line.	Tetradecanoylphorbol Acetate	85-88	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	195-198
8352523-4	1993	Conversely, TPA-induced differentiation resulted in transient appearance of c-fos, whereas no change in the level of c-sis and actin transcripts were observed.	Tetradecanoylphorbol Acetate	12-15	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-81
8287495-7	1994	Immunoprecipitation of 32P-labeled H-9 cells with antibodies to the beta 1 integrin subunit demonstrated phosphorylation of an alpha integrin subunit after treatment with TPA.	Tetradecanoylphorbol Acetate	171-174	integrin subunit beta 1	Homo sapiens	68-83
8275926-3	1994	In contrast, activin pretreatment increased the potency of both A23187 (Ca2+ ionophore) and phorbol 12-myristate 13-acetate [a protein kinase-C (PKC) activator] as secretagogues for FSH and LH release.	Tetradecanoylphorbol Acetate	92-123	protein kinase C, gamma	Rattus norvegicus	127-143
8275926-3	1994	In contrast, activin pretreatment increased the potency of both A23187 (Ca2+ ionophore) and phorbol 12-myristate 13-acetate [a protein kinase-C (PKC) activator] as secretagogues for FSH and LH release.	Tetradecanoylphorbol Acetate	92-123	protein kinase C, gamma	Rattus norvegicus	145-148
7813861-6	1994	TPA (12-0-tetradecanoylphorbol-13-acetate, 0.1-1 microM) dose-dependently increased the secretion of PYY and TGLP1 (maximal release at 328% and 326%, respectively), whereas 4 alpha-phorbol was ineffective.	Tetradecanoylphorbol Acetate	0-3	peptide YY	Rattus norvegicus	101-104
29563383-1	2018	To investigate whether focal adhesion kinase (FAK) can participate in the secretion of matrix metalloproteinase 9 (MMP9) after CD147 stimulation in THP-1 induced macrophages; thus, to explore the potential treatment perspectives for acute coronary syndrome (ACS).Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages.	Tetradecanoylphorbol Acetate	263-294	matrix metallopeptidase 9	Homo sapiens	115-119
8270871-3	1994	Stimulation of human neutrophils with PMA greatly increased O2(-)-generating activity and caused considerable translocation of the cytosolic components p47phox and p67phox.	Tetradecanoylphorbol Acetate	38-41	neutrophil cytosolic factor 1	Homo sapiens	152-159
8328965-4	1993	Treatment of THP-1 cells for 1-72 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) led to a stable enzyme activation, which was also found after partial purification of PLA2 from PMA-stimulated THP-1 cells.	Tetradecanoylphorbol Acetate	59-90	phospholipase A2 group IIA	Homo sapiens	183-187
8328965-4	1993	Treatment of THP-1 cells for 1-72 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) led to a stable enzyme activation, which was also found after partial purification of PLA2 from PMA-stimulated THP-1 cells.	Tetradecanoylphorbol Acetate	92-95	phospholipase A2 group IIA	Homo sapiens	183-187
29563383-1	2018	To investigate whether focal adhesion kinase (FAK) can participate in the secretion of matrix metalloproteinase 9 (MMP9) after CD147 stimulation in THP-1 induced macrophages; thus, to explore the potential treatment perspectives for acute coronary syndrome (ACS).Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages.	Tetradecanoylphorbol Acetate	296-299	matrix metallopeptidase 9	Homo sapiens	115-119
8398898-1	1993	The kinase activity of the BCR-ABL gene product is known to be down-regulated in K562 cells treated with low concentrations of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	145-181	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	27-34
7841543-5	1994	Northern blot analysis demonstrated that androgen induction of human glandular kallikrein-1 (hKLK2) mRNA was repressed by TPA in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	122-125	kallikrein related peptidase 2	Homo sapiens	93-98
7841543-6	1994	A time course study showed that both hKLK2 and c-myc mRNAs were repressed by TPA as early as four hours.	Tetradecanoylphorbol Acetate	77-80	kallikrein related peptidase 2	Homo sapiens	37-42
8398898-1	1993	The kinase activity of the BCR-ABL gene product is known to be down-regulated in K562 cells treated with low concentrations of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	183-186	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	27-34
29710490-8	2018	Therefore, the result demonstrates that the anti-metastatic effects of a proton beam in TPA-treated HepG2 cells are associated with the inhibition of MMP-9 activity and the down-regulations of MMP-9, uPA, uPAR, Snail-1 and VEGF gene expression via the p38 MAPK/c-Fos signaling pathway.	Tetradecanoylphorbol Acetate	88-91	matrix metallopeptidase 9	Homo sapiens	193-198
8398898-5	1993	Our results indicate that BCR-ABL/BCR complexes disappeared at precisely the same time after TPA treatment as the loss of autophosphorylation activity exhibited by total p210 BCR-ABL, which occurred 16-19 h after TPA treatment.	Tetradecanoylphorbol Acetate	93-96	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	26-33
8398898-5	1993	Our results indicate that BCR-ABL/BCR complexes disappeared at precisely the same time after TPA treatment as the loss of autophosphorylation activity exhibited by total p210 BCR-ABL, which occurred 16-19 h after TPA treatment.	Tetradecanoylphorbol Acetate	213-216	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	26-33
8398898-5	1993	Our results indicate that BCR-ABL/BCR complexes disappeared at precisely the same time after TPA treatment as the loss of autophosphorylation activity exhibited by total p210 BCR-ABL, which occurred 16-19 h after TPA treatment.	Tetradecanoylphorbol Acetate	213-216	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	175-182
8398898-6	1993	The loss of kinase activity preceded the loss of p210 BCR by more than 24 h. A degraded form of p210 BCR-ABL (about 175 kilodaltons) accounted for the residual autophosphorylation activity seen during the later phases of kinase inactivation following TPA treatment, and this form was preferentially sequestered within BCR-ABL/BCR complexes.	Tetradecanoylphorbol Acetate	251-254	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	101-108
8398898-8	1993	We conclude that 15 nM TPA treatment of K562 cells initiates effects that simultaneously interfere with the phosphorylation of p160 BCR in BCR-ABL complexes and inactivates the autophosphorylation activity of the full length BCR-ABL protein.	Tetradecanoylphorbol Acetate	23-26	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	139-146
7841543-9	1994	The above studies suggest that (1) the repression of androgen induction of gene expression by TPA-activated PKC is at least in part due to overexpression of c-jun and c-fos and (2) PKC may be a negative growth regulator in prostate cells.	Tetradecanoylphorbol Acetate	94-97	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-162
7841543-9	1994	The above studies suggest that (1) the repression of androgen induction of gene expression by TPA-activated PKC is at least in part due to overexpression of c-jun and c-fos and (2) PKC may be a negative growth regulator in prostate cells.	Tetradecanoylphorbol Acetate	94-97	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-172
8146021-5	1994	Conversely, PMA-induced inhibition of EPO mRNA accumulation was paralleled by translocation of PKC alpha from cytosol to membranes and the time- and dose-dependent attenuation of the inhibitory effect of PMA on EPO mRNA levels was paralleled by down-regulation of PKC alpha.	Tetradecanoylphorbol Acetate	12-15	protein kinase C, alpha	Rattus norvegicus	95-104
8398898-8	1993	We conclude that 15 nM TPA treatment of K562 cells initiates effects that simultaneously interfere with the phosphorylation of p160 BCR in BCR-ABL complexes and inactivates the autophosphorylation activity of the full length BCR-ABL protein.	Tetradecanoylphorbol Acetate	23-26	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	225-232
29710490-8	2018	Therefore, the result demonstrates that the anti-metastatic effects of a proton beam in TPA-treated HepG2 cells are associated with the inhibition of MMP-9 activity and the down-regulations of MMP-9, uPA, uPAR, Snail-1 and VEGF gene expression via the p38 MAPK/c-Fos signaling pathway.	Tetradecanoylphorbol Acetate	88-91	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	261-266
29628981-9	2018	12-O-tetradecanoylphorbol-13-acetate (TPA) induced MMP-9 expression and invasion in MCF-7 cell.	Tetradecanoylphorbol Acetate	0-36	matrix metallopeptidase 9	Homo sapiens	51-56
8403464-1	1993	The activity and gene expression of ornithine decarboxylase (ODC, an indicator of tumour promotion) were induced by the phorbol ester tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), in mouse skin.	Tetradecanoylphorbol Acetate	151-187	ornithine decarboxylase, structural 1	Mus musculus	36-59
8403464-1	1993	The activity and gene expression of ornithine decarboxylase (ODC, an indicator of tumour promotion) were induced by the phorbol ester tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), in mouse skin.	Tetradecanoylphorbol Acetate	151-187	ornithine decarboxylase, structural 1	Mus musculus	61-64
8403464-1	1993	The activity and gene expression of ornithine decarboxylase (ODC, an indicator of tumour promotion) were induced by the phorbol ester tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), in mouse skin.	Tetradecanoylphorbol Acetate	189-192	ornithine decarboxylase, structural 1	Mus musculus	36-59
8403464-1	1993	The activity and gene expression of ornithine decarboxylase (ODC, an indicator of tumour promotion) were induced by the phorbol ester tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), in mouse skin.	Tetradecanoylphorbol Acetate	189-192	ornithine decarboxylase, structural 1	Mus musculus	61-64
8146021-5	1994	Conversely, PMA-induced inhibition of EPO mRNA accumulation was paralleled by translocation of PKC alpha from cytosol to membranes and the time- and dose-dependent attenuation of the inhibitory effect of PMA on EPO mRNA levels was paralleled by down-regulation of PKC alpha.	Tetradecanoylphorbol Acetate	12-15	protein kinase C, alpha	Rattus norvegicus	264-273
8146021-5	1994	Conversely, PMA-induced inhibition of EPO mRNA accumulation was paralleled by translocation of PKC alpha from cytosol to membranes and the time- and dose-dependent attenuation of the inhibitory effect of PMA on EPO mRNA levels was paralleled by down-regulation of PKC alpha.	Tetradecanoylphorbol Acetate	204-207	protein kinase C, alpha	Rattus norvegicus	95-104
8146021-5	1994	Conversely, PMA-induced inhibition of EPO mRNA accumulation was paralleled by translocation of PKC alpha from cytosol to membranes and the time- and dose-dependent attenuation of the inhibitory effect of PMA on EPO mRNA levels was paralleled by down-regulation of PKC alpha.	Tetradecanoylphorbol Acetate	204-207	protein kinase C, alpha	Rattus norvegicus	264-273
7974918-1	1994	In the present study we investigated the effect of interferon-gamma (IFN-gamma) and phorbol-12-myristate 13 acetate (PMA) on intercellular adhesion molecule-1 (ICAM-1) antigen expression and shedding in human renal carcinoma cell cultures.	Tetradecanoylphorbol Acetate	84-115	intercellular adhesion molecule 1	Homo sapiens	125-158
7974918-1	1994	In the present study we investigated the effect of interferon-gamma (IFN-gamma) and phorbol-12-myristate 13 acetate (PMA) on intercellular adhesion molecule-1 (ICAM-1) antigen expression and shedding in human renal carcinoma cell cultures.	Tetradecanoylphorbol Acetate	84-115	intercellular adhesion molecule 1	Homo sapiens	160-166
7974918-1	1994	In the present study we investigated the effect of interferon-gamma (IFN-gamma) and phorbol-12-myristate 13 acetate (PMA) on intercellular adhesion molecule-1 (ICAM-1) antigen expression and shedding in human renal carcinoma cell cultures.	Tetradecanoylphorbol Acetate	117-120	intercellular adhesion molecule 1	Homo sapiens	125-158
8403464-3	1993	On administration of colchicine (100 micrograms) intraperitoneally 1.5 h before TPA treatment, ODC activity and ODC mRNA levels stimulated by TPA were suppressed to about 52 and 64%, respectively.	Tetradecanoylphorbol Acetate	142-145	ornithine decarboxylase, structural 1	Mus musculus	95-98
8403464-3	1993	On administration of colchicine (100 micrograms) intraperitoneally 1.5 h before TPA treatment, ODC activity and ODC mRNA levels stimulated by TPA were suppressed to about 52 and 64%, respectively.	Tetradecanoylphorbol Acetate	142-145	ornithine decarboxylase, structural 1	Mus musculus	112-115
7974918-1	1994	In the present study we investigated the effect of interferon-gamma (IFN-gamma) and phorbol-12-myristate 13 acetate (PMA) on intercellular adhesion molecule-1 (ICAM-1) antigen expression and shedding in human renal carcinoma cell cultures.	Tetradecanoylphorbol Acetate	117-120	intercellular adhesion molecule 1	Homo sapiens	160-166
29628981-9	2018	12-O-tetradecanoylphorbol-13-acetate (TPA) induced MMP-9 expression and invasion in MCF-7 cell.	Tetradecanoylphorbol Acetate	38-41	matrix metallopeptidase 9	Homo sapiens	51-56
8268240-4	1993	Stimulation of porcine neutrophils with either myristic acid or phorbol myristate acetate resulted in great enhancement of the oxidase activity, and in considerable translocation of p49-phox and p63-phox.	Tetradecanoylphorbol Acetate	64-89	serum response factor binding protein 1	Homo sapiens	182-185
8314857-0	1993	1,25-Dihydroxy vitamin D3 and 12-O-tetradecanoyl phorbol-13-acetate synergistically induce monocytic cell differentiation: FOS and RB expression.	Tetradecanoylphorbol Acetate	30-67	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-126
29628981-12	2018	The selective PPARgamma antagonist GW9662 reversed MMP-9 inhibition by troglitazone in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	87-90	matrix metallopeptidase 9	Homo sapiens	51-56
8391009-2	1993	Monocytic differentiation of HL-60 cells by TPA (12-0-tetradecanoyl phorbol-13-acetate) has been reported to be paralleled by increased AP-1 binding to DNA and by elevated c-jun expression, suggesting transcriptional level of control.	Tetradecanoylphorbol Acetate	44-47	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-140
8391009-2	1993	Monocytic differentiation of HL-60 cells by TPA (12-0-tetradecanoyl phorbol-13-acetate) has been reported to be paralleled by increased AP-1 binding to DNA and by elevated c-jun expression, suggesting transcriptional level of control.	Tetradecanoylphorbol Acetate	44-47	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-177
27467093-7	2018	The tubercular uveitis group demonstrated heightened Th1, Th17 responses following in vitro stimulation with phorbol myristate acetate (PMA)/ionomycin.	Tetradecanoylphorbol Acetate	136-139	negative elongation factor complex member C/D	Homo sapiens	53-56
8405374-4	1993	TPA-treated cells showed binding for C3b and weak binding for C3 and C3d.	Tetradecanoylphorbol Acetate	0-3	complement C3	Homo sapiens	37-40
8405374-5	1993	Taken together, the data suggest that Raji cells may express three binding sites for C3, C3b and C3d which can be differently modulated by anti-CR2 MoAbs and TPA.	Tetradecanoylphorbol Acetate	158-161	complement C3	Homo sapiens	89-92
8505313-3	1993	The immune complex phosphatase assay using the antibody demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) and a vitamin D metabolite increased the PTP activity of immunoprecipitated PTP1C to 230 and 150% of control, respectively.	Tetradecanoylphorbol Acetate	74-110	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	193-198
8505313-3	1993	The immune complex phosphatase assay using the antibody demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) and a vitamin D metabolite increased the PTP activity of immunoprecipitated PTP1C to 230 and 150% of control, respectively.	Tetradecanoylphorbol Acetate	112-115	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	193-198
8505313-5	1993	The time course increment by TPA of PTP1C activity was closely correlated with that of the acquisition by HL-60 cells of a macrophage-like phenotype.	Tetradecanoylphorbol Acetate	29-32	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	36-41
8505313-6	1993	In addition, TPA increased the amount of PTP1C detected by immunoblotting and immunoprecipitation and raised the level of expression of PTP1C mRNA in HL-60 cells.	Tetradecanoylphorbol Acetate	13-16	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	41-46
8280066-0	1993	Phorbol 12-myristate 13-acetate-stimulated phosphorylation of erythrocyte membrane skeletal proteins is blocked by calpain inhibitors: possible role of protein kinase M. Human erythrocytes contain cytosolic protein kinase C (PKC) which, when activated by phorbol 12-myristate 13-acetate (PMA), induces the phosphorylation of the membrane skeletal proteins band 4.1, band 4.9 and adducin.	Tetradecanoylphorbol Acetate	0-31	erythrocyte membrane protein band 4.1	Homo sapiens	356-364
8280080-12	1993	In human vein endothelial cells it enhanced the PMA-mediated induction of MMP-9, whereas it suppressed this induction in human microvascular endothelial cells and in synovial fibroblasts.	Tetradecanoylphorbol Acetate	48-51	matrix metallopeptidase 9	Homo sapiens	74-79
8253535-0	1993	TPA-enhanced invasion of Matrigel associated with augmentation of cell motility but not metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1.	Tetradecanoylphorbol Acetate	0-3	troponin I3, cardiac type	Homo sapiens	194-199
8253535-1	1993	We previously found that the enhanced activity to invade Matrigel upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) was one of the major properties of a highly metastatic variant (L-10) of a human rectal adenocarcinoma cell line RCM-1.	Tetradecanoylphorbol Acetate	88-124	troponin I3, cardiac type	Homo sapiens	244-249
8253535-1	1993	We previously found that the enhanced activity to invade Matrigel upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA) was one of the major properties of a highly metastatic variant (L-10) of a human rectal adenocarcinoma cell line RCM-1.	Tetradecanoylphorbol Acetate	126-129	troponin I3, cardiac type	Homo sapiens	244-249
8505313-6	1993	In addition, TPA increased the amount of PTP1C detected by immunoblotting and immunoprecipitation and raised the level of expression of PTP1C mRNA in HL-60 cells.	Tetradecanoylphorbol Acetate	13-16	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	136-141
8505313-7	1993	The increase of PTP1C mRNA induced by TPA treatment was inhibited by cycloheximide, suggesting that new protein synthesis is required for the increase by TPA of PTP1C mRNA expression.	Tetradecanoylphorbol Acetate	38-41	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	16-21
29259250-3	2017	Herein, we investigated how Snail upregulated transcription of ZEB1 and MMP9 induced by the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA) in hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	107-144	zinc finger E-box binding homeobox 1	Homo sapiens	63-67
8505313-7	1993	The increase of PTP1C mRNA induced by TPA treatment was inhibited by cycloheximide, suggesting that new protein synthesis is required for the increase by TPA of PTP1C mRNA expression.	Tetradecanoylphorbol Acetate	38-41	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	161-166
8505313-7	1993	The increase of PTP1C mRNA induced by TPA treatment was inhibited by cycloheximide, suggesting that new protein synthesis is required for the increase by TPA of PTP1C mRNA expression.	Tetradecanoylphorbol Acetate	154-157	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	16-21
8505313-7	1993	The increase of PTP1C mRNA induced by TPA treatment was inhibited by cycloheximide, suggesting that new protein synthesis is required for the increase by TPA of PTP1C mRNA expression.	Tetradecanoylphorbol Acetate	154-157	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	161-166
7504152-2	1993	When HEL cells were treated with 10(-7) M TPA, glycophorin A expression and hemoglobin synthesis were reduced, while the expression of GP IIb/IIIa was induced in association with the morphological changes.	Tetradecanoylphorbol Acetate	42-45	integrin subunit alpha 2b	Homo sapiens	135-141
8505313-8	1993	Furthermore, TPA increased the rate of transcription of the PTP1C gene without affecting the stability of PTP1C mRNA.	Tetradecanoylphorbol Acetate	13-16	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	60-65
29259250-3	2017	Herein, we investigated how Snail upregulated transcription of ZEB1 and MMP9 induced by the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA) in hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	107-144	matrix metallopeptidase 9	Homo sapiens	72-76
8505313-9	1993	These results suggest that (i) two subtypes of PTP1C may exist and function in various cell types, and (ii) TPA stimulates the PTP activity of PTP1C by increasing the transcription rate of PTP1C gene expression.	Tetradecanoylphorbol Acetate	108-111	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	47-52
8505313-9	1993	These results suggest that (i) two subtypes of PTP1C may exist and function in various cell types, and (ii) TPA stimulates the PTP activity of PTP1C by increasing the transcription rate of PTP1C gene expression.	Tetradecanoylphorbol Acetate	108-111	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	143-148
8505313-9	1993	These results suggest that (i) two subtypes of PTP1C may exist and function in various cell types, and (ii) TPA stimulates the PTP activity of PTP1C by increasing the transcription rate of PTP1C gene expression.	Tetradecanoylphorbol Acetate	108-111	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	143-148
8227003-2	1993	Phorbol 12-myristate 13-acetate (PMA) and okadaic acid, an inhibitor of serine/threonine phosphatases, stimulated arachidonic acid release, supporting a role for phosphorylation events in regulating PLA2 activation.	Tetradecanoylphorbol Acetate	0-31	phospholipase A2, group IB, pancreas	Mus musculus	199-203
29259250-3	2017	Herein, we investigated how Snail upregulated transcription of ZEB1 and MMP9 induced by the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA) in hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	146-149	zinc finger E-box binding homeobox 1	Homo sapiens	63-67
8103344-1	1993	Incubation of the human renal carcinoma cell line CaKi-1 with interferon-gamma (IFN-gamma) or the phorbol ester, phorbol-12-myristate 13-acetate (PMA) strongly stimulated the immunocytochemical expression of the intercellular adhesion molecule-1 (ICAM-1) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	113-144	intercellular adhesion molecule 1	Homo sapiens	212-245
8103344-1	1993	Incubation of the human renal carcinoma cell line CaKi-1 with interferon-gamma (IFN-gamma) or the phorbol ester, phorbol-12-myristate 13-acetate (PMA) strongly stimulated the immunocytochemical expression of the intercellular adhesion molecule-1 (ICAM-1) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	113-144	intercellular adhesion molecule 1	Homo sapiens	247-253
29259250-3	2017	Herein, we investigated how Snail upregulated transcription of ZEB1 and MMP9 induced by the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA) in hepatoma cell HepG2.	Tetradecanoylphorbol Acetate	146-149	matrix metallopeptidase 9	Homo sapiens	72-76
8103344-1	1993	Incubation of the human renal carcinoma cell line CaKi-1 with interferon-gamma (IFN-gamma) or the phorbol ester, phorbol-12-myristate 13-acetate (PMA) strongly stimulated the immunocytochemical expression of the intercellular adhesion molecule-1 (ICAM-1) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	146-149	intercellular adhesion molecule 1	Homo sapiens	212-245
8103344-1	1993	Incubation of the human renal carcinoma cell line CaKi-1 with interferon-gamma (IFN-gamma) or the phorbol ester, phorbol-12-myristate 13-acetate (PMA) strongly stimulated the immunocytochemical expression of the intercellular adhesion molecule-1 (ICAM-1) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	146-149	intercellular adhesion molecule 1	Homo sapiens	247-253
8227003-2	1993	Phorbol 12-myristate 13-acetate (PMA) and okadaic acid, an inhibitor of serine/threonine phosphatases, stimulated arachidonic acid release, supporting a role for phosphorylation events in regulating PLA2 activation.	Tetradecanoylphorbol Acetate	33-36	phospholipase A2, group IB, pancreas	Mus musculus	199-203
29259250-4	2017	According to deletion mapping and site directed mutagenesis analysis, the TPA-responsive elements on both MMP9 and ZEB1 promoters locate on a putative EGR1 and SP1 overlapping region coupled with an upstream proposed Snail binding motif TCACA.	Tetradecanoylphorbol Acetate	74-77	matrix metallopeptidase 9	Homo sapiens	106-110
8227003-4	1993	The 85-kDa PLA2 was phosphorylated on serine in the macrophages, and the level of phosphorylation increased in response to zymosan, PMA, okadaic acid, and, to a lesser extent, A23187.	Tetradecanoylphorbol Acetate	132-135	phospholipase A2, group IB, pancreas	Mus musculus	11-15
8227003-6	1993	Zymosan, PMA, A23187, or okadaic acid stimulated time-dependent increases in PLA2 activity in the cytosolic fraction.	Tetradecanoylphorbol Acetate	9-12	phospholipase A2, group IB, pancreas	Mus musculus	77-81
8500546-4	1993	Heat shock protein 70 gene was initially down regulated and was induced only after 48 h. The well-differentiated malignant keratinocyte cell line differed in that the c-fos, GADD, SPR1, and IL1-beta genes had several-fold higher induction, but involucrin mRNA was undetectable and fibronectin mRNA was only minimally induced after TPA stimulation.	Tetradecanoylphorbol Acetate	331-334	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-172
8500546-4	1993	Heat shock protein 70 gene was initially down regulated and was induced only after 48 h. The well-differentiated malignant keratinocyte cell line differed in that the c-fos, GADD, SPR1, and IL1-beta genes had several-fold higher induction, but involucrin mRNA was undetectable and fibronectin mRNA was only minimally induced after TPA stimulation.	Tetradecanoylphorbol Acetate	331-334	Sp4 transcription factor	Homo sapiens	180-184
29259250-4	2017	According to deletion mapping and site directed mutagenesis analysis, the TPA-responsive elements on both MMP9 and ZEB1 promoters locate on a putative EGR1 and SP1 overlapping region coupled with an upstream proposed Snail binding motif TCACA.	Tetradecanoylphorbol Acetate	74-77	zinc finger E-box binding homeobox 1	Homo sapiens	115-119
29259250-5	2017	Consistently, chromatin immunoprecipitation (ChIP) assay showed TPA triggered binding of Snail, EGR1 and SP1 on MMP9 and ZEB1 promoters.	Tetradecanoylphorbol Acetate	64-67	matrix metallopeptidase 9	Homo sapiens	112-116
8359866-1	1993	CD8 (Ly-2) expression was suppressed in purified murine CD4-CD8+ thymocytes at the mRNA level upon continuous stimulation with PMA and ionomycin in the presence of rIL-2.	Tetradecanoylphorbol Acetate	127-130	CD4 antigen	Mus musculus	56-59
7694572-3	1993	Treatment of macrophages with vanadate plus TPA led to activation of protein kinase C (PKC) and NADPH oxidase (O2- generation in intact cells), massive cellular protein tyrosine phosphorylation, suppression of protein tyrosine phosphatase (PTP) activity and a sustained activation of protein tyrosine kinase (PTK) and myelin basic protein kinase activity (the latter three enzyme activities were assessed in cell lysates).	Tetradecanoylphorbol Acetate	44-47	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	210-238
29259250-5	2017	Consistently, chromatin immunoprecipitation (ChIP) assay showed TPA triggered binding of Snail, EGR1 and SP1 on MMP9 and ZEB1 promoters.	Tetradecanoylphorbol Acetate	64-67	zinc finger E-box binding homeobox 1	Homo sapiens	121-125
7694572-3	1993	Treatment of macrophages with vanadate plus TPA led to activation of protein kinase C (PKC) and NADPH oxidase (O2- generation in intact cells), massive cellular protein tyrosine phosphorylation, suppression of protein tyrosine phosphatase (PTP) activity and a sustained activation of protein tyrosine kinase (PTK) and myelin basic protein kinase activity (the latter three enzyme activities were assessed in cell lysates).	Tetradecanoylphorbol Acetate	44-47	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	240-243
8389253-3	1993	Recent studies from this laboratory have shown that TPA significantly enhances formation of hydrogen peroxide (H2O2) and oxidized DNA bases in SENCAR mouse skin, as it increases the infiltration of polymorphonuclear leukocytes (PMNs), as quantitated by myeloperoxidase (MPO).	Tetradecanoylphorbol Acetate	52-55	myeloperoxidase	Mus musculus	253-268
8389253-3	1993	Recent studies from this laboratory have shown that TPA significantly enhances formation of hydrogen peroxide (H2O2) and oxidized DNA bases in SENCAR mouse skin, as it increases the infiltration of polymorphonuclear leukocytes (PMNs), as quantitated by myeloperoxidase (MPO).	Tetradecanoylphorbol Acetate	52-55	myeloperoxidase	Mus musculus	270-273
7694572-5	1993	Vanadate plus H2O2 mimicked the effect of vanadate plus TPA on PKC activation, cellular protein tyrosine phosphorylation, PTP and PTK, but their effects were resistant to DPI.	Tetradecanoylphorbol Acetate	56-59	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	122-125
29259250-7	2017	Also, electrophoresis mobility shift assay revealed TPA enhanced binding of Snail with a MMP9 promoter fragment.	Tetradecanoylphorbol Acetate	52-55	matrix metallopeptidase 9	Homo sapiens	89-93
8389253-7	1993	Comparison of the net values indicated that 4 micrograms TPA enhanced PMN infiltration (MPO units/cm2) and oxidant formation (nmol H2O2/cm2) in SENCAR mice by 7.7- and 11-fold respectively over those present in TPA-treated C57BL/6J mouse skin.	Tetradecanoylphorbol Acetate	57-60	myeloperoxidase	Mus musculus	88-91
8491187-9	1993	We also show that stimulation of HeLa cells with the phorbol ester TPA enhances phosphorylation of PTP1B.	Tetradecanoylphorbol Acetate	67-70	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	99-104
8130084-4	1993	After treatment for 24 h, TNF-beta caused a marked down-regulation of PKC similar to that seen after 24 h treatment with TPA; significant activation persisted, however, in the cells treated for 24 h with TNF-alpha.	Tetradecanoylphorbol Acetate	121-124	lymphotoxin alpha	Homo sapiens	26-34
29270166-6	2017	The whole blood of the patient produced 35% less IFN-gamma compared to controls assessed by ELISA and flow cytometry, but IL-17 producing T cells from patient were almost absent in PBMC stimulated with PMA plus ionomycin.	Tetradecanoylphorbol Acetate	202-205	interleukin 17A	Homo sapiens	122-127
8491187-12	1993	Thus the TPA-stimulated phosphorylation of PTP1B in vivo appears to result directly from phosphorylation by PKC.	Tetradecanoylphorbol Acetate	9-12	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	43-48
8491187-13	1993	The effect of phosphorylation on the activity of PTP1B has been examined in immunoprecipitates from TPA-treated and nocodazole-arrested cells.	Tetradecanoylphorbol Acetate	100-103	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	49-54
8504805-2	1993	Treatment with okadaic acid caused rapid phosphorylation of five proteins with molecular masses of 65, 55, 50, 28 and 15 kDa (p65, p55, p50, p28, p15, respectively) while TPA caused rapid phosphorylation of five proteins with molecular masses of 80, 70, 40, 34 and 28 kDa (p80, p70, p40, p34, p28, respectively).	Tetradecanoylphorbol Acetate	171-174	interleukin 12b	Mus musculus	283-286
28888989-0	2017	Noradrenaline, oxymetazoline and phorbol myristate acetate induce distinct functional actions and phosphorylation patterns of alpha1A-adrenergic receptors.	Tetradecanoylphorbol Acetate	33-58	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	126-133
8340356-2	1993	The phosphorylation of p50 was also stimulated by a protein kinase C activator, phorbol myristate acetate (PMA), but not by a calcium ionophore, A23187.	Tetradecanoylphorbol Acetate	80-105	lymphocyte specific 1	Mus musculus	23-26
8340356-2	1993	The phosphorylation of p50 was also stimulated by a protein kinase C activator, phorbol myristate acetate (PMA), but not by a calcium ionophore, A23187.	Tetradecanoylphorbol Acetate	107-110	lymphocyte specific 1	Mus musculus	23-26
8242857-1	1993	The frequency and spectrum of Ha-ras mutations in benzo[a]pyrene (B[a]P)-initiated/12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted CD-1 mouse skin papillomas were characterized by amplifying high molecular weight papilloma DNA using the polymerase chain reaction (PCR) followed by direct DNA sequencing.	Tetradecanoylphorbol Acetate	83-119	Harvey rat sarcoma virus oncogene	Mus musculus	30-36
8242857-1	1993	The frequency and spectrum of Ha-ras mutations in benzo[a]pyrene (B[a]P)-initiated/12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted CD-1 mouse skin papillomas were characterized by amplifying high molecular weight papilloma DNA using the polymerase chain reaction (PCR) followed by direct DNA sequencing.	Tetradecanoylphorbol Acetate	121-124	Harvey rat sarcoma virus oncogene	Mus musculus	30-36
7903158-8	1993	Stimulation with anti-CD28 mAb in conjunction with phorbol myristate acetate and ionomycin promotes cell cycling in the CD2- subset of CD4-CD8- T cells, and results in a slight induction of CD2 levels during the course of the culture period.	Tetradecanoylphorbol Acetate	51-76	CD4 antigen	Mus musculus	135-138
29130110-0	2017	Epimedium koreanum Nakai inhibits PMA-induced cancer cell migration and invasion by modulating NF-kappaB/MMP-9 signaling in monomorphic malignant human glioma cells.	Tetradecanoylphorbol Acetate	34-37	matrix metallopeptidase 9	Homo sapiens	105-110
8234287-5	1993	The levels of Oct-2 mRNA and protein were increased in activated cells, were increased to a lesser extent in the PMA-treated cells, and were undetectable in resting cells.	Tetradecanoylphorbol Acetate	113-116	POU class 2 homeobox 2	Homo sapiens	14-19
8491988-0	1993	12-O-tetradecanoylphorbol-13-acetate not only modulates proliferation rates, but also alters antigen expression and LAK-cell susceptibility of normal human melanocytes in vitro.	Tetradecanoylphorbol Acetate	0-36	alpha kinase 1	Homo sapiens	116-119
8491988-6	1993	In contrast, the expression of the differentiation marker K.1.2 and of intercellular adhesion molecule-1 was decreased in TPA-treated cultures.	Tetradecanoylphorbol Acetate	122-125	intercellular adhesion molecule 1	Homo sapiens	71-104
8473886-2	1993	The secretion of CPE enzymatic activity from astrocytes has been shown previously to be increased approximately twofold by treatment with tetradecanoylphorbol 13-acetate (TPA), a phorbol ester.	Tetradecanoylphorbol Acetate	171-174	carboxypeptidase E	Mus musculus	17-20
29130110-5	2017	Additionally, pre- or post-treatment with PMA followed by EYK decreased MMP-9 activity in A172 cells.	Tetradecanoylphorbol Acetate	42-45	matrix metallopeptidase 9	Homo sapiens	72-77
8473886-3	1993	In this study, metabolic labeling with [35S]Met was utilized to examine the effect of TPA on the biosynthesis of CPE protein in cultured astrocytes and in AtT-20 cells, a pituitary-derived cell line.	Tetradecanoylphorbol Acetate	86-89	carboxypeptidase E	Mus musculus	113-116
8473886-4	1993	Treatment of astrocytes with 0.1 micrograms/ml TPA for 24 h caused an 80% increase in the level of radiolabeled CPE in both the media and the cells, indicating that the synthesis of CPE was stimulated by the TPA.	Tetradecanoylphorbol Acetate	47-50	carboxypeptidase E	Mus musculus	112-115
8400300-6	1993	When CD11b/CD18 expressing K562 cells were stimulated with phorbol myristate acetate (50 ng/mL) for 24 to 48 hours, these K562 cells formed dense cell:cell aggregates.	Tetradecanoylphorbol Acetate	59-84	integrin subunit alpha M	Homo sapiens	5-10
29130110-8	2017	Taken together, our results suggest that EYK suppresses PMA-induced cancer cell migration in monomorphic malignant human glioma cells by downregulating the NF-kappaB pathway and decreasing MMP-9 activity.	Tetradecanoylphorbol Acetate	56-59	matrix metallopeptidase 9	Homo sapiens	189-194
8473886-4	1993	Treatment of astrocytes with 0.1 micrograms/ml TPA for 24 h caused an 80% increase in the level of radiolabeled CPE in both the media and the cells, indicating that the synthesis of CPE was stimulated by the TPA.	Tetradecanoylphorbol Acetate	47-50	carboxypeptidase E	Mus musculus	182-185
8473886-4	1993	Treatment of astrocytes with 0.1 micrograms/ml TPA for 24 h caused an 80% increase in the level of radiolabeled CPE in both the media and the cells, indicating that the synthesis of CPE was stimulated by the TPA.	Tetradecanoylphorbol Acetate	208-211	carboxypeptidase E	Mus musculus	112-115
29132393-11	2017	Furthermore, 96 h after induction of the lytic cycle with either TPA (Akata) or TGF-beta (MUTU-1), IFI16 protein levels decreased up to 80% as compared to the EBV-negative cell line BJAB.	Tetradecanoylphorbol Acetate	65-68	interferon gamma inducible protein 16	Homo sapiens	99-104
8473886-4	1993	Treatment of astrocytes with 0.1 micrograms/ml TPA for 24 h caused an 80% increase in the level of radiolabeled CPE in both the media and the cells, indicating that the synthesis of CPE was stimulated by the TPA.	Tetradecanoylphorbol Acetate	208-211	carboxypeptidase E	Mus musculus	182-185
8473886-5	1993	AtT-20 cells also secreted more radiolabeled CPE in response to TPA, but this increase was offset by a proportional decrease in the cellular level of radiolabeled CPE, and synthesis of CPE was not stimulated in this cell line.	Tetradecanoylphorbol Acetate	64-67	carboxypeptidase E	Mus musculus	45-48
8473886-6	1993	Northern blot analysis demonstrated that 0.1 micrograms/ml TPA elevated CPE mRNA by approximately 50% in cultured astrocytes but not in AtT-20 cells.	Tetradecanoylphorbol Acetate	59-62	carboxypeptidase E	Mus musculus	72-75
8473886-7	1993	Quantitative in situ hybridization studies demonstrated that the TPA-induced increase in CPE mRNA expression was largely due to increases in the number of cells expressing CPE mRNA, although for astrocytes from some brain regions the average level of CPE mRNA per cell was also elevated by TPA.	Tetradecanoylphorbol Acetate	65-68	carboxypeptidase E	Mus musculus	89-92
8473886-7	1993	Quantitative in situ hybridization studies demonstrated that the TPA-induced increase in CPE mRNA expression was largely due to increases in the number of cells expressing CPE mRNA, although for astrocytes from some brain regions the average level of CPE mRNA per cell was also elevated by TPA.	Tetradecanoylphorbol Acetate	65-68	carboxypeptidase E	Mus musculus	172-175
8473886-7	1993	Quantitative in situ hybridization studies demonstrated that the TPA-induced increase in CPE mRNA expression was largely due to increases in the number of cells expressing CPE mRNA, although for astrocytes from some brain regions the average level of CPE mRNA per cell was also elevated by TPA.	Tetradecanoylphorbol Acetate	65-68	carboxypeptidase E	Mus musculus	172-175
8473886-7	1993	Quantitative in situ hybridization studies demonstrated that the TPA-induced increase in CPE mRNA expression was largely due to increases in the number of cells expressing CPE mRNA, although for astrocytes from some brain regions the average level of CPE mRNA per cell was also elevated by TPA.	Tetradecanoylphorbol Acetate	290-293	carboxypeptidase E	Mus musculus	89-92
8274878-2	1993	Basal and PTH- and forskolin-stimulated adenylate cyclase activities were determined in the presence or absence of 100 nM phorbol 12-myristate 13-acetate (PMA), the activator of PKC, in ROS 17/2.8 cells that had been previously cultured with or without dexamethasone or 1,25(OH)2D3.	Tetradecanoylphorbol Acetate	155-158	protein kinase C, gamma	Rattus norvegicus	178-181
8242260-14	1993	The protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but not the biologically inactive 4 alpha-phorbol 12,13-didecanoate, increased phospholipase D activity in mesangial cells, suggesting that PKC may mediate nucleotide-induced phosphatidylcholine hydrolysis.	Tetradecanoylphorbol Acetate	38-69	protein kinase C, alpha	Rattus norvegicus	22-25
8242260-14	1993	The protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but not the biologically inactive 4 alpha-phorbol 12,13-didecanoate, increased phospholipase D activity in mesangial cells, suggesting that PKC may mediate nucleotide-induced phosphatidylcholine hydrolysis.	Tetradecanoylphorbol Acetate	38-69	protein kinase C, alpha	Rattus norvegicus	217-220
8242260-14	1993	The protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but not the biologically inactive 4 alpha-phorbol 12,13-didecanoate, increased phospholipase D activity in mesangial cells, suggesting that PKC may mediate nucleotide-induced phosphatidylcholine hydrolysis.	Tetradecanoylphorbol Acetate	71-74	protein kinase C, alpha	Rattus norvegicus	22-25
8242260-14	1993	The protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), but not the biologically inactive 4 alpha-phorbol 12,13-didecanoate, increased phospholipase D activity in mesangial cells, suggesting that PKC may mediate nucleotide-induced phosphatidylcholine hydrolysis.	Tetradecanoylphorbol Acetate	71-74	protein kinase C, alpha	Rattus norvegicus	217-220
8392417-2	1993	KM-3 cells are lymphoblastoid cells expressing the TdT and when induced to differentiate by phorbol ester (PMA) they loose this enzyme.	Tetradecanoylphorbol Acetate	107-110	DNA nucleotidylexotransferase	Homo sapiens	51-54
28731287-4	2017	Our results demonstrated that tricetin attenuates 12-O-tetradecanoylphorbol-13-acetate-induced SCC-9, HSC-3, and OECM-1 cell invasiveness and migration by reducing matrix metalloproteinase (MMP)-9 enzyme activity.	Tetradecanoylphorbol Acetate	50-86	DnaJ heat shock protein family (Hsp40) member B7	Homo sapiens	102-107
8467792-7	1993	The stimulation of transformed myelomonocytic cells or of normal peripheral blood macrophages with kinases or LPS or TPA respectively, led to the rapid redistribution of NF-M protein from the cell bodies to the nucleus, consistent with the notion that NF-M was directly affected by such treatments.	Tetradecanoylphorbol Acetate	117-120	neurofilament medium chain	Homo sapiens	170-174
8467792-7	1993	The stimulation of transformed myelomonocytic cells or of normal peripheral blood macrophages with kinases or LPS or TPA respectively, led to the rapid redistribution of NF-M protein from the cell bodies to the nucleus, consistent with the notion that NF-M was directly affected by such treatments.	Tetradecanoylphorbol Acetate	117-120	neurofilament medium chain	Homo sapiens	252-256
8314909-3	1993	TNF alpha also induced the production of MMP-9 by TPA-untreated U937 cells without morphological differentiation.	Tetradecanoylphorbol Acetate	50-53	matrix metallopeptidase 9	Homo sapiens	41-46
8242260-16	1993	Down-regulation of PKC-alpha and -delta isoenzymes by 8 h PMA treatment still resulted in full phospholipase D activation.	Tetradecanoylphorbol Acetate	58-61	protein kinase C, alpha	Rattus norvegicus	19-28
8223588-9	1993	After exposure to phorbol 12-myristate 13-acetate, a complete depletion of PKC-beta was observed within 1 h and the complete depletion of PKC-alpha and PKC-delta isotypes was observed within 4 h. In contrast, PKC-epsilon was only partially down-regulated after a 24-h treatment with phorbol 12-myristate 13-acetate and PKC-zeta was not affected at all.	Tetradecanoylphorbol Acetate	18-49	protein kinase C, delta	Mus musculus	152-161
8406825-5	1993	PMA completely restored IL-6 production and partially that of CSF.	Tetradecanoylphorbol Acetate	0-3	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	62-65
8314909-6	1993	MMP-9 was purified to homogeneity as an inactive zymogen with M(r) 92,000 (proMMP-9) from TPA-differentiated U937 cells treated with TNF alpha.	Tetradecanoylphorbol Acetate	90-93	matrix metallopeptidase 9	Homo sapiens	0-5
28731287-4	2017	Our results demonstrated that tricetin attenuates 12-O-tetradecanoylphorbol-13-acetate-induced SCC-9, HSC-3, and OECM-1 cell invasiveness and migration by reducing matrix metalloproteinase (MMP)-9 enzyme activity.	Tetradecanoylphorbol Acetate	50-86	matrix metallopeptidase 9	Homo sapiens	164-196
8105372-6	1993	This treatment resulted in the inhibition of phorbol 12-myristate 13-acetate (PMA)-induced cellular adhesion, morphological changes, and the expression of leukocyte integrin CD11b.	Tetradecanoylphorbol Acetate	45-76	integrin subunit alpha M	Homo sapiens	174-179
29198314-10	2017	Following 72 h culture of T cells in SMG (SMG-T) or control static (Static-T) conditions, IL-2 production by the T cells was reduced in SMG-T cells compared to Static-T cells upon stimulation by phorbol 12-myristate 13-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	195-226	sterile alpha motif domain containing 4A	Homo sapiens	37-40
8105372-6	1993	This treatment resulted in the inhibition of phorbol 12-myristate 13-acetate (PMA)-induced cellular adhesion, morphological changes, and the expression of leukocyte integrin CD11b.	Tetradecanoylphorbol Acetate	78-81	integrin subunit alpha M	Homo sapiens	174-179
8384354-1	1993	Expression of immediate-early genes involving the 12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive element (TRE) is modulated by post-translational modification of pre-existing activator protein 1 (AP-1) constituents.	Tetradecanoylphorbol Acetate	89-92	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	183-202
29198314-10	2017	Following 72 h culture of T cells in SMG (SMG-T) or control static (Static-T) conditions, IL-2 production by the T cells was reduced in SMG-T cells compared to Static-T cells upon stimulation by phorbol 12-myristate 13-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	195-226	sterile alpha motif domain containing 4A	Homo sapiens	42-47
8384354-1	1993	Expression of immediate-early genes involving the 12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive element (TRE) is modulated by post-translational modification of pre-existing activator protein 1 (AP-1) constituents.	Tetradecanoylphorbol Acetate	89-92	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	204-208
8378087-2	1993	The chimaeric Fos-ER proteins showed estrogen-inducible activation of TRE (TPA-responsive element)-directed transcription and hormone-dependent transformation of fibroblasts.	Tetradecanoylphorbol Acetate	75-78	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-17
29198314-10	2017	Following 72 h culture of T cells in SMG (SMG-T) or control static (Static-T) conditions, IL-2 production by the T cells was reduced in SMG-T cells compared to Static-T cells upon stimulation by phorbol 12-myristate 13-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	195-226	sterile alpha motif domain containing 4A	Homo sapiens	136-141
8384844-3	1993	Employing Northern blotting, a sandwich enzyme-linked immunosorbent assay and immunocytochemical analysis we determined MRP8/MRP14 mRNA and protein levels, which were found to be elevated after VD3 and reduced after TPA treatment.	Tetradecanoylphorbol Acetate	216-219	S100 calcium binding protein A9	Homo sapiens	125-130
29198314-10	2017	Following 72 h culture of T cells in SMG (SMG-T) or control static (Static-T) conditions, IL-2 production by the T cells was reduced in SMG-T cells compared to Static-T cells upon stimulation by phorbol 12-myristate 13-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	228-231	sterile alpha motif domain containing 4A	Homo sapiens	37-40
29198314-10	2017	Following 72 h culture of T cells in SMG (SMG-T) or control static (Static-T) conditions, IL-2 production by the T cells was reduced in SMG-T cells compared to Static-T cells upon stimulation by phorbol 12-myristate 13-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	228-231	sterile alpha motif domain containing 4A	Homo sapiens	42-47
8095029-2	1993	Treatment of hepatocytes with EGF in combination with phorbol ester (TPA) resulted in an additive decrease of PEPCK mRNA levels.	Tetradecanoylphorbol Acetate	69-72	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	110-115
28842814-11	2017	Activation of PKCgamma by PMA aggravated allodynia and increased the expression of CGRP and c-Fos.	Tetradecanoylphorbol Acetate	26-29	protein kinase C, gamma	Rattus norvegicus	14-22
8095029-3	1993	Overnight pretreatment of hepatocytes with TPA, which is known to downregulate protein kinase C, abolished the TPA and reduced the EGF-mediated inhibition of PEPCK gene expression.	Tetradecanoylphorbol Acetate	43-46	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	158-163
8095395-4	1993	In addition, TPA- or 1,25-dihydroxyvitamin D3-mediated differentiation of the U937 cell line into a macrophage-like phenotype was associated with increased expression of ICAM-1.	Tetradecanoylphorbol Acetate	13-16	intercellular adhesion molecule 1	Homo sapiens	170-176
7507605-12	1993	Phorbol 12-Myristate 13-Acetate (PMA), a tumor promoter, alone had no effect on [3H]thymidine incorporation, but its addition suppressed the stimulatory effect of EGF when they were added simultaneously in the presence of 5% FBS.	Tetradecanoylphorbol Acetate	0-31	epidermal growth factor	Gallus gallus	163-166
7507605-12	1993	Phorbol 12-Myristate 13-Acetate (PMA), a tumor promoter, alone had no effect on [3H]thymidine incorporation, but its addition suppressed the stimulatory effect of EGF when they were added simultaneously in the presence of 5% FBS.	Tetradecanoylphorbol Acetate	33-36	epidermal growth factor	Gallus gallus	163-166
8095395-5	1993	In both cell lines, two ICAM-1 mRNA transcripts were found, and expression was stimulated to a similar degree within 1 to 2 h after addition of TPA.	Tetradecanoylphorbol Acetate	144-147	intercellular adhesion molecule 1	Homo sapiens	24-30
28842814-11	2017	Activation of PKCgamma by PMA aggravated allodynia and increased the expression of CGRP and c-Fos.	Tetradecanoylphorbol Acetate	26-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-97
8095395-6	1993	In both cell lines, the anti-inflammatory corticosteroid dexamethasone repressed both constitutive and TPA-stimulated ICAM-1 expression, within 3 h of its addition.	Tetradecanoylphorbol Acetate	103-106	intercellular adhesion molecule 1	Homo sapiens	118-124
28992327-10	2017	Using a two-stage DMBA/TPA-induced skin cancer model, we find that PAQR4-deleted mice are resistant to chemical carcinogen-induced tumor formation.	Tetradecanoylphorbol Acetate	23-26	progestin and adipoQ receptor family member IV	Mus musculus	67-72
8460940-9	1993	In the present study, we have demonstrated that a myelocytic leukemic cell line (HL-60) produces and secretes PAF-AH into a defined medium when the cells are differentiated into macrophages following stimulation by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	215-251	phospholipase A2 group VII	Homo sapiens	110-116
8460940-9	1993	In the present study, we have demonstrated that a myelocytic leukemic cell line (HL-60) produces and secretes PAF-AH into a defined medium when the cells are differentiated into macrophages following stimulation by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	253-256	phospholipase A2 group VII	Homo sapiens	110-116
8460940-11	1993	Stimulation with TPA caused a dose- and time-dependent increase in PAF-AH activity in the media.	Tetradecanoylphorbol Acetate	17-20	phospholipase A2 group VII	Homo sapiens	67-73
28970848-0	2017	Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells.	Tetradecanoylphorbol Acetate	34-70	matrix metallopeptidase 9	Homo sapiens	93-119
28970848-0	2017	Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells.	Tetradecanoylphorbol Acetate	34-70	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	128-147
8452537-3	1993	Stimulation of cardiomyocytes with 4 beta-phorbol 12-myristate 13-acetate (PMA) led to a rapid increase in particulate-bound PKC activity, a response attributed to the activation of alpha-, delta- and zeta- type PKCs but not beta-type PKC.	Tetradecanoylphorbol Acetate	35-73	protein kinase C, alpha	Rattus norvegicus	125-128
8452537-3	1993	Stimulation of cardiomyocytes with 4 beta-phorbol 12-myristate 13-acetate (PMA) led to a rapid increase in particulate-bound PKC activity, a response attributed to the activation of alpha-, delta- and zeta- type PKCs but not beta-type PKC.	Tetradecanoylphorbol Acetate	35-73	protein kinase C, alpha	Rattus norvegicus	212-215
28970848-9	2017	Furthermore, CFE attenuated the TPA-induced activation of AP-1.	Tetradecanoylphorbol Acetate	32-35	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-62
8452537-3	1993	Stimulation of cardiomyocytes with 4 beta-phorbol 12-myristate 13-acetate (PMA) led to a rapid increase in particulate-bound PKC activity, a response attributed to the activation of alpha-, delta- and zeta- type PKCs but not beta-type PKC.	Tetradecanoylphorbol Acetate	75-78	protein kinase C, alpha	Rattus norvegicus	125-128
8452537-3	1993	Stimulation of cardiomyocytes with 4 beta-phorbol 12-myristate 13-acetate (PMA) led to a rapid increase in particulate-bound PKC activity, a response attributed to the activation of alpha-, delta- and zeta- type PKCs but not beta-type PKC.	Tetradecanoylphorbol Acetate	75-78	protein kinase C, alpha	Rattus norvegicus	212-215
28927117-0	2017	Salvia miltiorrhiza extract inhibits TPA-induced MMP-9 expression and invasion through the MAPK/AP-1 signaling pathway in human breast cancer MCF-7 cells.	Tetradecanoylphorbol Acetate	37-40	matrix metallopeptidase 9	Homo sapiens	49-54
8452537-5	1993	Confirming this, 4 beta-phorbol 12-monoacetate and 4 alpha-phorbol had no effect on cellular eicosanoid formation, while the PMA-induced response was fully abolished both in the presence of the PKC inhibitors staurosporine and CGP 41251 and in PKC-down-regulated cells.	Tetradecanoylphorbol Acetate	125-128	protein kinase C, alpha	Rattus norvegicus	194-197
8452537-5	1993	Confirming this, 4 beta-phorbol 12-monoacetate and 4 alpha-phorbol had no effect on cellular eicosanoid formation, while the PMA-induced response was fully abolished both in the presence of the PKC inhibitors staurosporine and CGP 41251 and in PKC-down-regulated cells.	Tetradecanoylphorbol Acetate	125-128	protein kinase C, alpha	Rattus norvegicus	244-247
8436593-4	1993	Downregulation of protein kinase C (PKC) by high doses of phorbol esters or selective PKC inhibitors prevented the induction of this mRNA by NGF, suggesting that NGF and TPA act through a common PKC-dependent pathway.	Tetradecanoylphorbol Acetate	170-173	protein kinase C, gamma	Rattus norvegicus	18-34
8436593-4	1993	Downregulation of protein kinase C (PKC) by high doses of phorbol esters or selective PKC inhibitors prevented the induction of this mRNA by NGF, suggesting that NGF and TPA act through a common PKC-dependent pathway.	Tetradecanoylphorbol Acetate	170-173	protein kinase C, gamma	Rattus norvegicus	36-39
8436593-4	1993	Downregulation of protein kinase C (PKC) by high doses of phorbol esters or selective PKC inhibitors prevented the induction of this mRNA by NGF, suggesting that NGF and TPA act through a common PKC-dependent pathway.	Tetradecanoylphorbol Acetate	170-173	protein kinase C, gamma	Rattus norvegicus	86-89
8387158-3	1993	We then studied the effects of cAMP- and protein kinase-C-dependent pathways on the expression of 3 beta HSD-I and 17 beta HSD-II genes using an analog of cAMP [8-(4-chlorophenylthio)cAMP (8CPTcAMP)] and a protein kinase-C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), in JEG-3 cells.	Tetradecanoylphorbol Acetate	240-271	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	98-110
8387158-8	1993	When JEG-3 cells were exposed to 8CPTcAMP or PMA, 3 beta HSD-I and 17 beta HSD-II gene transcriptions were increased in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	45-48	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	50-62
28927117-6	2017	The inhibitory effects of SME on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression were assessed using western blotting, reverse transcription-quantitative polymerase chain reaction and zymography assays.	Tetradecanoylphorbol Acetate	33-69	matrix metallopeptidase 9	Homo sapiens	84-89
8387158-9	1993	Moreover, the combined effects of PMA and 8CPTcAMP on 3 beta HSD-I mRNA levels was additive and synergistic on 17 beta HSD-II mRNA levels.	Tetradecanoylphorbol Acetate	34-37	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	54-66
28927117-6	2017	The inhibitory effects of SME on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression were assessed using western blotting, reverse transcription-quantitative polymerase chain reaction and zymography assays.	Tetradecanoylphorbol Acetate	71-74	matrix metallopeptidase 9	Homo sapiens	84-89
28927117-9	2017	The present study demonstrated the inhibitory effects of the SME ethanol solution on MMP-9 expression and cell invasion in TPA-treated MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	123-126	matrix metallopeptidase 9	Homo sapiens	85-90
8455768-6	1993	Inhibition of PKC activity by prolonged treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) or staurosporine, a potent PKC inhibitor, before irradiation enhanced radiation-induced DNA damage and attenuated the repair of damaged DNA.	Tetradecanoylphorbol Acetate	55-91	protein kinase C, gamma	Rattus norvegicus	14-17
28927117-10	2017	SME suppressed TPA-induced MMP-9 expression and MCF-7 cell invasion by blocking the transcriptional activation of AP-1.	Tetradecanoylphorbol Acetate	15-18	matrix metallopeptidase 9	Homo sapiens	27-32
8455768-6	1993	Inhibition of PKC activity by prolonged treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) or staurosporine, a potent PKC inhibitor, before irradiation enhanced radiation-induced DNA damage and attenuated the repair of damaged DNA.	Tetradecanoylphorbol Acetate	93-96	protein kinase C, gamma	Rattus norvegicus	14-17
28895863-7	2017	Using this system we found that stimulation of equine peripheral blood mononuclear cells (PBMC) with phorbol 12-myristate 13-acetate (PMA) and ionomycin induced IL-2 secretion most potently.	Tetradecanoylphorbol Acetate	101-132	interleukin 2	Equus caballus	161-165
8094032-10	1993	These results suggest that although PMA-induced ICAM-1 expression is PKC dependent on HS 683 and SK-N-SH cells, the stimulation of ICAM-1 expression by retinoic acid and by IFN-gamma may be due to PKC inactivation at longer time points (24 h), as mimicked by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, staurosporine, or PKC depletion by high doses of PMA.	Tetradecanoylphorbol Acetate	36-39	intercellular adhesion molecule 1	Homo sapiens	48-54
8094032-10	1993	These results suggest that although PMA-induced ICAM-1 expression is PKC dependent on HS 683 and SK-N-SH cells, the stimulation of ICAM-1 expression by retinoic acid and by IFN-gamma may be due to PKC inactivation at longer time points (24 h), as mimicked by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, staurosporine, or PKC depletion by high doses of PMA.	Tetradecanoylphorbol Acetate	36-39	intercellular adhesion molecule 1	Homo sapiens	131-137
28895863-7	2017	Using this system we found that stimulation of equine peripheral blood mononuclear cells (PBMC) with phorbol 12-myristate 13-acetate (PMA) and ionomycin induced IL-2 secretion most potently.	Tetradecanoylphorbol Acetate	134-137	interleukin 2	Equus caballus	161-165
8428966-6	1993	Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone.	Tetradecanoylphorbol Acetate	101-132	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-38
28895863-9	2017	After stimulation of equine PBMC with PMA and ionomycin, IL-2 production was detected in 13.0% (range 7.5-16.8%) of the lymphocytes by flow cytometric analysis.	Tetradecanoylphorbol Acetate	38-41	interleukin 2	Equus caballus	57-61
8428966-6	1993	Constitutive expression in vivo of Fos, and to a lesser extent Fra-1, eliminates the requirement for phorbol 12-myristate 13-acetate (PMA) stimulation, leaving NF-AT-directed transcription responsive to calcium ionophore alone.	Tetradecanoylphorbol Acetate	134-137	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-38
28827793-9	2017	Our results support the model: following phorbol 12-myristate 13-acetate (PMA) or TCR/CD3 activation of T cells, LPAP is rapidly dephosphorylated at Ser-99 and Ser-172 and slowly phosphorylated at Ser-163.	Tetradecanoylphorbol Acetate	41-72	protein tyrosine phosphatase receptor type C associated protein	Homo sapiens	113-117
8435870-0	1993	Inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced increase in ornithine decarboxylase mRNA in mouse epidermis.	Tetradecanoylphorbol Acetate	33-69	ornithine decarboxylase, structural 1	Mus musculus	90-113
28827793-9	2017	Our results support the model: following phorbol 12-myristate 13-acetate (PMA) or TCR/CD3 activation of T cells, LPAP is rapidly dephosphorylated at Ser-99 and Ser-172 and slowly phosphorylated at Ser-163.	Tetradecanoylphorbol Acetate	74-77	protein tyrosine phosphatase receptor type C associated protein	Homo sapiens	113-117
8435870-1	1993	Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration.	Tetradecanoylphorbol Acetate	22-58	ornithine decarboxylase, structural 1	Mus musculus	155-178
8435870-1	1993	Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration.	Tetradecanoylphorbol Acetate	22-58	ornithine decarboxylase, structural 1	Mus musculus	180-183
28402957-5	2017	Furthermore, we notice that a series of genes, including PI3KCA, NFATC1and TNFSF9, which play important roles during NK cell activation, were at "poised" state prior to activation, and that modifications of H3K4me3 and H3K27me3 on these promotors were sensitive to stimulation with Phorbol Myristate Acetate (PMA) and Ionomycin (Iono) in the NK92MI cell line.	Tetradecanoylphorbol Acetate	282-307	nuclear factor of activated T cells 1	Homo sapiens	65-71
8435870-1	1993	Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration.	Tetradecanoylphorbol Acetate	60-63	ornithine decarboxylase, structural 1	Mus musculus	155-178
8435870-1	1993	Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration.	Tetradecanoylphorbol Acetate	60-63	ornithine decarboxylase, structural 1	Mus musculus	180-183
8435870-1	1993	Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration.	Tetradecanoylphorbol Acetate	272-275	ornithine decarboxylase, structural 1	Mus musculus	155-178
8435870-1	1993	Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration.	Tetradecanoylphorbol Acetate	272-275	ornithine decarboxylase, structural 1	Mus musculus	180-183
8435870-2	1993	The concentration of epidermal ODC mRNA then decreased rapidly during the next 5 h. The time course for TPA-induced increases in epidermal ODC enzyme activity paralleled very closely the time course for TPA-induced increases in ODC mRNA.	Tetradecanoylphorbol Acetate	104-107	ornithine decarboxylase, structural 1	Mus musculus	31-34
8435870-2	1993	The concentration of epidermal ODC mRNA then decreased rapidly during the next 5 h. The time course for TPA-induced increases in epidermal ODC enzyme activity paralleled very closely the time course for TPA-induced increases in ODC mRNA.	Tetradecanoylphorbol Acetate	104-107	ornithine decarboxylase, structural 1	Mus musculus	139-142
8435870-2	1993	The concentration of epidermal ODC mRNA then decreased rapidly during the next 5 h. The time course for TPA-induced increases in epidermal ODC enzyme activity paralleled very closely the time course for TPA-induced increases in ODC mRNA.	Tetradecanoylphorbol Acetate	104-107	ornithine decarboxylase, structural 1	Mus musculus	139-142
8435870-2	1993	The concentration of epidermal ODC mRNA then decreased rapidly during the next 5 h. The time course for TPA-induced increases in epidermal ODC enzyme activity paralleled very closely the time course for TPA-induced increases in ODC mRNA.	Tetradecanoylphorbol Acetate	203-206	ornithine decarboxylase, structural 1	Mus musculus	31-34
28498408-8	2017	However, subsequent re-stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin resulted in enhanced IL-17 production and expression, particularly in CD4+ surface CXCR3 positive cells.	Tetradecanoylphorbol Acetate	40-71	interleukin 17A	Homo sapiens	113-118
8435870-3	1993	Topical administration of 1, 3 or 10 mumol curcumin together with 5 nmol TPA inhibited by 66, 81 and 91% respectively TPA-induced increases in epidermal ODC enzyme activity measured 5 h later.	Tetradecanoylphorbol Acetate	73-76	ornithine decarboxylase, structural 1	Mus musculus	153-156
8435870-3	1993	Topical administration of 1, 3 or 10 mumol curcumin together with 5 nmol TPA inhibited by 66, 81 and 91% respectively TPA-induced increases in epidermal ODC enzyme activity measured 5 h later.	Tetradecanoylphorbol Acetate	118-121	ornithine decarboxylase, structural 1	Mus musculus	153-156
8435870-4	1993	In a parallel study, TPA-induced increases in the concentration of epidermal ODC mRNA was inhibited by 54, 85 and 82% respectively.	Tetradecanoylphorbol Acetate	21-24	ornithine decarboxylase, structural 1	Mus musculus	77-80
8472849-3	1993	In contrast to the effect of PMA, the inactive analog phorbol had no effect on PDGF-A chain mRNA levels, while the PKC inhibitor H7 markedly reduced the PMA-induced increment in PDGF-A chain mRNA.	Tetradecanoylphorbol Acetate	153-156	platelet derived growth factor subunit A	Homo sapiens	178-190
28498408-8	2017	However, subsequent re-stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin resulted in enhanced IL-17 production and expression, particularly in CD4+ surface CXCR3 positive cells.	Tetradecanoylphorbol Acetate	73-76	interleukin 17A	Homo sapiens	113-118
28322979-8	2017	In addition, MDMA induces a short-term increase in both tPA activity and expression, a serine-protease which is involved in BBB disruption and upregulation of MMP-9 expression.	Tetradecanoylphorbol Acetate	56-59	matrix metallopeptidase 9	Rattus norvegicus	159-164
8275798-5	1993	When cells were pretreated with the protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), PAF-elicited Ca(2+)-signal was diminished substantially.	Tetradecanoylphorbol Acetate	64-95	patchy fur	Mus musculus	103-106
8275798-5	1993	When cells were pretreated with the protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), PAF-elicited Ca(2+)-signal was diminished substantially.	Tetradecanoylphorbol Acetate	97-100	patchy fur	Mus musculus	103-106
28492556-1	2017	Multiple lines of evidence have demonstrated that increased expression of phospholipid scramblase 1 (PLSCR1) is involved in the differentiation of acute myeloid leukemia (AML) cells by several differentiation-inducing agents including ATRA and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	244-275	phospholipid scramblase 1	Homo sapiens	74-99
8081948-14	1993	Phorbol 12-myristate 13-acetate stimulation of PKC caused down-regulation of PKC-alpha, -delta and -epsilon isoenzymes in epithelial and mesangial cells.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, alpha	Rattus norvegicus	47-50
8081948-14	1993	Phorbol 12-myristate 13-acetate stimulation of PKC caused down-regulation of PKC-alpha, -delta and -epsilon isoenzymes in epithelial and mesangial cells.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, alpha	Rattus norvegicus	77-107
8416791-3	1993	In this work we investigated c-fos and c-jun gene expression and AP-1-(12-O-tetradecanoylphorbol-13-acetate)-responsive enhancer element (TRE) binding activity during keratinocyte differentiation utilizing both authentic and in culture-reconstituted human epidermis.	Tetradecanoylphorbol Acetate	71-107	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-69
8225036-13	1993	Unlike fMLP, phorbol myristate acetate (PMA), which has been most commonly used in spin trapping studies, induced superoxide release which was not influenced by cell adhesion.	Tetradecanoylphorbol Acetate	13-38	spindlin 1	Homo sapiens	83-87
8225036-13	1993	Unlike fMLP, phorbol myristate acetate (PMA), which has been most commonly used in spin trapping studies, induced superoxide release which was not influenced by cell adhesion.	Tetradecanoylphorbol Acetate	40-43	spindlin 1	Homo sapiens	83-87
8244198-1	1993	Culture of two lymphoid leukemia cell lines with 5 x 10(-9) to 10(-7) M 12-0-tetradecanoyl-phorbol 13-acetate (TPA) induced the significant increase in sialyltransferase, acid phosphatase and butyrate esterase activities, the decrease in poly(A) polymerase and terminal deoxynucleotidyl transferase (TdT) activities.	Tetradecanoylphorbol Acetate	111-114	DNA nucleotidylexotransferase	Homo sapiens	261-298
8244198-1	1993	Culture of two lymphoid leukemia cell lines with 5 x 10(-9) to 10(-7) M 12-0-tetradecanoyl-phorbol 13-acetate (TPA) induced the significant increase in sialyltransferase, acid phosphatase and butyrate esterase activities, the decrease in poly(A) polymerase and terminal deoxynucleotidyl transferase (TdT) activities.	Tetradecanoylphorbol Acetate	111-114	DNA nucleotidylexotransferase	Homo sapiens	300-303
8244198-2	1993	B4-, J5-, TdT- or PNA-positive cells were decreased in TPA-treated cells, while B1-positive cells were increased.	Tetradecanoylphorbol Acetate	55-58	DNA nucleotidylexotransferase	Homo sapiens	10-13
8098501-3	1993	Administration of morphine significantly inhibited the phorbol myristate acetate (PMA)-stimulated increase in interleukin-2 receptor (IL-2R) expression in both CD4+ and CD8+ mouse T cells.	Tetradecanoylphorbol Acetate	55-80	interleukin 2 receptor, alpha chain	Mus musculus	110-132
8098501-3	1993	Administration of morphine significantly inhibited the phorbol myristate acetate (PMA)-stimulated increase in interleukin-2 receptor (IL-2R) expression in both CD4+ and CD8+ mouse T cells.	Tetradecanoylphorbol Acetate	55-80	interleukin 2 receptor, alpha chain	Mus musculus	134-139
8098501-3	1993	Administration of morphine significantly inhibited the phorbol myristate acetate (PMA)-stimulated increase in interleukin-2 receptor (IL-2R) expression in both CD4+ and CD8+ mouse T cells.	Tetradecanoylphorbol Acetate	82-85	interleukin 2 receptor, alpha chain	Mus musculus	110-132
8098501-3	1993	Administration of morphine significantly inhibited the phorbol myristate acetate (PMA)-stimulated increase in interleukin-2 receptor (IL-2R) expression in both CD4+ and CD8+ mouse T cells.	Tetradecanoylphorbol Acetate	82-85	interleukin 2 receptor, alpha chain	Mus musculus	134-139
8352882-1	1993	The goal of this study was to compare the response of mouse epidermal keratinocytes (MEKs) and human epidermal keratinocytes (HEKs) to 12-O-tetradecanoylphorbol-13-acetate (TPA) with respect to the activation and downregulation of protein kinase C (PKC), the expression of c-jun and c-fos, and the expression and induction of ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	135-171	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	273-278
8352882-1	1993	The goal of this study was to compare the response of mouse epidermal keratinocytes (MEKs) and human epidermal keratinocytes (HEKs) to 12-O-tetradecanoylphorbol-13-acetate (TPA) with respect to the activation and downregulation of protein kinase C (PKC), the expression of c-jun and c-fos, and the expression and induction of ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	135-171	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	283-288
8384457-6	1993	Preincubation of SENCAR MPs with 100 microM dibromoacetophenone, an inhibitor of phospholipase A2, completely suppressed the superoxide induced by TPA and TG stimulation.	Tetradecanoylphorbol Acetate	147-150	phospholipase A2, group IB, pancreas	Mus musculus	81-97
8094920-1	1993	Incubation of the human renal carcinoma cell line CaKi-1 with tumour necrosis factor alpha (TNF alpha) or the phorbol ester phorbol-12-myristate 13 acetate (PMA) strongly enhanced the immunocytochemical staining of the intercellular adhesion molecule ICAM-1, in a non-linear manner.	Tetradecanoylphorbol Acetate	124-155	intercellular adhesion molecule 1	Homo sapiens	251-257
8094920-1	1993	Incubation of the human renal carcinoma cell line CaKi-1 with tumour necrosis factor alpha (TNF alpha) or the phorbol ester phorbol-12-myristate 13 acetate (PMA) strongly enhanced the immunocytochemical staining of the intercellular adhesion molecule ICAM-1, in a non-linear manner.	Tetradecanoylphorbol Acetate	157-160	intercellular adhesion molecule 1	Homo sapiens	251-257
8216342-5	1993	Likewise, the PK-C activator 12,O,tetradecanoyl phorbol 13 acetate (TPA) reduces both the efficacy of secretin and the potency of cholecystokinin.	Tetradecanoylphorbol Acetate	68-71	protein kinase C, gamma	Rattus norvegicus	14-18
8216342-5	1993	Likewise, the PK-C activator 12,O,tetradecanoyl phorbol 13 acetate (TPA) reduces both the efficacy of secretin and the potency of cholecystokinin.	Tetradecanoylphorbol Acetate	68-71	secretin	Rattus norvegicus	102-110
8396935-4	1993	Phorbol myristate acetate (PMA), another activator of EL4.NOB-1 cells, had an opposite effect to IL-1 in that it increased binding site expression dramatically suggesting different mechanisms of action for these two effectors.	Tetradecanoylphorbol Acetate	0-25	epilepsy 4	Mus musculus	54-57
8396935-4	1993	Phorbol myristate acetate (PMA), another activator of EL4.NOB-1 cells, had an opposite effect to IL-1 in that it increased binding site expression dramatically suggesting different mechanisms of action for these two effectors.	Tetradecanoylphorbol Acetate	27-30	epilepsy 4	Mus musculus	54-57
8103055-3	1993	Preincubation with the PKC activators phorbol-12-myristate-13-acetate (PMA) (3-300 nM) or 1-oleyl-2-acetyl-glycerol (OAG) (30 microM) significantly attenuated the release of NO and PGI2 from EC stimulated with bradykinin (0.3-30 nM), whereas phorbol-12,13-didecanoate (PDD) (30-300 nM), which does not activate PKC, had no effect.	Tetradecanoylphorbol Acetate	38-69	kininogen 1	Bos taurus	210-220
8103055-5	1993	These effects were correlated with a reduced (PMA) or enhanced (UCN-01) elevation of intracellular Ca2+ in response to bradykinin in both types of EC.	Tetradecanoylphorbol Acetate	46-49	kininogen 1	Bos taurus	119-129
8103055-8	1993	Incubation of bovine EC with PMA elicited a significant increase in membrane-bound PKC alpha immunoreactivity, whereas there was no translocation of PKC alpha from the cytosolic to the membrane fraction with bradykinin.	Tetradecanoylphorbol Acetate	29-32	protein kinase C alpha	Bos taurus	83-92
7692906-8	1993	ACH-2 can be converted to productive infection by stimulation of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), mitogen or cytokines (TNF-alpha), or infection with HSV.	Tetradecanoylphorbol Acetate	80-116	acyl-CoA thioesterase 1	Homo sapiens	0-5
7692906-8	1993	ACH-2 can be converted to productive infection by stimulation of the cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), mitogen or cytokines (TNF-alpha), or infection with HSV.	Tetradecanoylphorbol Acetate	118-121	acyl-CoA thioesterase 1	Homo sapiens	0-5
8101106-7	1993	Furthermore, the p65 antisense oligomer effectively abolished an upregulation of CD11b that was produced by formyl-met-leu-phe and TPA.	Tetradecanoylphorbol Acetate	131-134	integrin subunit alpha M	Homo sapiens	81-86
8325838-4	1993	Time- and calcium-dependent vesiculation of platelets in response to ADP, collagen, thrombin, phorbol myristate acetate, and the thrombin peptide SFLLRN were dramatically inhibited, in a concentration-dependent manner, by monoclonal antibodies to GPIIb-IIIa (A2A9, 7E3, PAC1) and RGDS.	Tetradecanoylphorbol Acetate	94-119	integrin subunit alpha 2b	Homo sapiens	247-252
8325838-7	1993	A central role for GPIIb-IIIa is supported by the near total inability of Glanzmann"s thrombasthenic (type I) platelets to vesiculate in response to thrombin, ADP, collagen, and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	178-209	integrin subunit alpha 2b	Homo sapiens	19-24
8232274-8	1993	In addition, we show that like the ANF-R1A, the ANF-R1C guanylyl cyclase activity can be regulated by phosphorylation since preincubation with TPA or FKL attenuates the subsequent stimulation by CNP in cultured cells.	Tetradecanoylphorbol Acetate	143-146	natriuretic peptide C	Homo sapiens	195-198
8401297-2	1993	The c-fos expression of iron deprived cells retained its response to stimulation by TPA, and cytosolic PKC activity did not decline after iron deprivation.	Tetradecanoylphorbol Acetate	84-87	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-9
8100719-4	1993	When stimulated with anti-CD3 and phorbol 12-myristate 13-acetate, purified patient CD8+ T cells exhibited significantly decreased proliferation, c-myc expression, and interleukin-2 (IL-2) production compared with that of normal CD8+ T cells.	Tetradecanoylphorbol Acetate	34-65	CD8a molecule	Homo sapiens	84-87
8100719-4	1993	When stimulated with anti-CD3 and phorbol 12-myristate 13-acetate, purified patient CD8+ T cells exhibited significantly decreased proliferation, c-myc expression, and interleukin-2 (IL-2) production compared with that of normal CD8+ T cells.	Tetradecanoylphorbol Acetate	34-65	CD8a molecule	Homo sapiens	229-232
28492556-1	2017	Multiple lines of evidence have demonstrated that increased expression of phospholipid scramblase 1 (PLSCR1) is involved in the differentiation of acute myeloid leukemia (AML) cells by several differentiation-inducing agents including ATRA and phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	244-275	phospholipid scramblase 1	Homo sapiens	101-107
28322331-6	2017	Western blot analysis showed that both phosphorylated STAT3 and phosphorylated AKT expressions were significantly increased in epidermis of TC-PTP-deficient mice compared to control mice following TPA treatment.	Tetradecanoylphorbol Acetate	197-200	protein tyrosine phosphatase, non-receptor type 2	Mus musculus	140-146
28098862-5	2017	Phorbol 12-myristate 13-acetate (PMA), which is a Rac1 activator, significantly enhanced the expression levels of MMP-2, -3, -9 and -19 proteins, whereas the results of rhein and Rac1 inhibitor NSC23766 were just the opposite.	Tetradecanoylphorbol Acetate	0-31	Rac family small GTPase 1	Homo sapiens	50-54
28098862-5	2017	Phorbol 12-myristate 13-acetate (PMA), which is a Rac1 activator, significantly enhanced the expression levels of MMP-2, -3, -9 and -19 proteins, whereas the results of rhein and Rac1 inhibitor NSC23766 were just the opposite.	Tetradecanoylphorbol Acetate	0-31	Rac family small GTPase 1	Homo sapiens	179-183
28098862-5	2017	Phorbol 12-myristate 13-acetate (PMA), which is a Rac1 activator, significantly enhanced the expression levels of MMP-2, -3, -9 and -19 proteins, whereas the results of rhein and Rac1 inhibitor NSC23766 were just the opposite.	Tetradecanoylphorbol Acetate	33-36	Rac family small GTPase 1	Homo sapiens	50-54
28098862-5	2017	Phorbol 12-myristate 13-acetate (PMA), which is a Rac1 activator, significantly enhanced the expression levels of MMP-2, -3, -9 and -19 proteins, whereas the results of rhein and Rac1 inhibitor NSC23766 were just the opposite.	Tetradecanoylphorbol Acetate	33-36	Rac family small GTPase 1	Homo sapiens	179-183
28098862-8	2017	Furthermore, rhein significantly inhibited JNK, AP-1 phosphorylation in the cells treated with PMA.	Tetradecanoylphorbol Acetate	95-98	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	48-52
28097492-9	2017	TRPM2 and TRPV1 currents were increased by the PKC activator, phorbol myristate acetate (PMA), although the currents were decreased by ACA, CPZ, and the PKC inhibitor, bisindolylmaleimide I (BIM).	Tetradecanoylphorbol Acetate	89-92	protein kinase C, gamma	Rattus norvegicus	47-50
28351321-6	2017	We demonstrate that temsirolimus and torin 1 effectively reduced the constitutive as well as phorbol-myristate-acetate/oncostatin-M-induced expression of mesenchymal markers (fibronectin, vimentin, and YKL40) and neural stem cell markers (Sox2, Oct4, nestin, and mushashi1).	Tetradecanoylphorbol Acetate	93-118	SRY-box transcription factor 2	Homo sapiens	239-243
29098164-0	2017	Cell Signaling Pathway in 12-O-Tetradecanoylphorbol-13-acetate-Induced LCN2 Gene Transcription in Esophageal Squamous Cell Carcinoma.	Tetradecanoylphorbol Acetate	26-62	lipocalin 2	Homo sapiens	71-75
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	73-109	lipocalin 2	Homo sapiens	37-41
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	73-109	protein phosphatase 1 regulatory subunit 18	Homo sapiens	220-227
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	73-109	lipocalin 2	Homo sapiens	331-335
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	111-114	lipocalin 2	Homo sapiens	37-41
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	111-114	protein phosphatase 1 regulatory subunit 18	Homo sapiens	220-227
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	111-114	lipocalin 2	Homo sapiens	331-335
29098164-3	2017	Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXRbeta) at a novel TPA-responsive element (TRE), at -152~-60 bp of the 5" flanking region of the LCN2 promoter.	Tetradecanoylphorbol Acetate	253-256	lipocalin 2	Homo sapiens	37-41
29098164-8	2017	We found that MISP, KLF10, KLF15, PPP1R18, and RXRbeta proteins could strongly respond to TPA stimulation and activate LCN2 transcriptional expression.	Tetradecanoylphorbol Acetate	90-93	protein phosphatase 1 regulatory subunit 18	Homo sapiens	34-41
8392184-3	1993	The treatment of endothelial cells with either phorbol 12-myristate 13-acetate (100 nM) to activate protein kinase C (PKC) or forskolin (10 microM) to stimulate adenylate cyclase sharply decreased ET-1 mRNA.	Tetradecanoylphorbol Acetate	47-78	endothelin 1	Bos taurus	197-201
29098164-8	2017	We found that MISP, KLF10, KLF15, PPP1R18, and RXRbeta proteins could strongly respond to TPA stimulation and activate LCN2 transcriptional expression.	Tetradecanoylphorbol Acetate	90-93	lipocalin 2	Homo sapiens	119-123
28373608-6	2017	Pre-treatment with quercetin and rottlerin, PKCdelta signaling inhibitors, significantly suppressed the PMA-induced elevation of glucagon secretion.	Tetradecanoylphorbol Acetate	104-107	protein kinase C, delta	Mus musculus	44-52
8389757-11	1993	Activity of the mitogen-activated protein kinase family with associated phosphorylation of c-Jun Y-peptide was markedly diminished in TPA-treated HL-60/vinc cells, but not in response to okadaic acid.	Tetradecanoylphorbol Acetate	134-137	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-96
8242794-8	1993	Expression of ornithine decarboxylase mRNA and protein is increased by vinblastine sulfate but decreased by cytochalasin B in TPA treated cells.	Tetradecanoylphorbol Acetate	126-129	ornithine decarboxylase, structural 1	Mus musculus	14-37
8489251-8	1993	Preincubation of cells with 500 nM TPA overnight resulted in the inhibition of insulin- and TPA-stimulated 2-[3H]DOG uptake.	Tetradecanoylphorbol Acetate	35-38	insulin	Canis lupus familiaris	79-86
8390855-7	1993	Because Ha-Ras requires isoprenylation for membrane binding, we examined the effect of the isoprenylation inhibitors lovastatin and perillic acid on PMA-induced c-Jun phosphorylation.	Tetradecanoylphorbol Acetate	149-152	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	161-166
8316048-7	1993	AA-Supplemented (1.6 microM) cultures supported approximately twice the induction of ornithine decarboxylase activity by TPA compared with cultures treated with 1.8 microM LA.	Tetradecanoylphorbol Acetate	121-124	ornithine decarboxylase, structural 1	Mus musculus	85-108
8321620-9	1993	Pretreatment with PKC inhibitors, staurosporine or PKCI, prevented the TPA-dependent decrease in gj.	Tetradecanoylphorbol Acetate	71-74	protein kinase C, gamma	Rattus norvegicus	18-21
8321620-9	1993	Pretreatment with PKC inhibitors, staurosporine or PKCI, prevented the TPA-dependent decrease in gj.	Tetradecanoylphorbol Acetate	71-74	protein kinase C, gamma	Rattus norvegicus	51-55
8463255-7	1993	However, only the mutation of the proximal, but not the distal PEA-3 site, significantly inhibited the TPA response.	Tetradecanoylphorbol Acetate	103-106	ETS variant transcription factor 4	Homo sapiens	63-68
8463255-9	1993	These data suggest that the PEA-3 site, but not the activator protein-1 site, and Ets-2 protein have a major role in the TPA induction of the human stromelysin gene transcription.	Tetradecanoylphorbol Acetate	121-124	ETS variant transcription factor 4	Homo sapiens	28-33
8494821-2	1993	We previously reported that CLE2/GC-box (at positions -95 to -73, which is homologous to the NF-kappa B binding site) and CLE0 (at positions to -40) of the mouse GM-CSF promoter are essential for transcriptional activation in response to phorbol-12-myristate-13-acetate (PMA)/calcium ionophore (A23187).	Tetradecanoylphorbol Acetate	271-274	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	162-168
8494827-4	1993	Here we show that protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) causes a decrease of both CD4 and CD8 expression at the cell surface level and at the mRNA level in a CD4+ CD8+ T cell line and in freshly isolated thymocytes.	Tetradecanoylphorbol Acetate	55-86	CD8a molecule	Homo sapiens	127-130
8494827-4	1993	Here we show that protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) causes a decrease of both CD4 and CD8 expression at the cell surface level and at the mRNA level in a CD4+ CD8+ T cell line and in freshly isolated thymocytes.	Tetradecanoylphorbol Acetate	55-86	CD8a molecule	Homo sapiens	200-203
8494827-4	1993	Here we show that protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) causes a decrease of both CD4 and CD8 expression at the cell surface level and at the mRNA level in a CD4+ CD8+ T cell line and in freshly isolated thymocytes.	Tetradecanoylphorbol Acetate	88-91	CD8a molecule	Homo sapiens	127-130
8494827-4	1993	Here we show that protein kinase C (PKC) activation by phorbol 12-myristate 13-acetate (PMA) causes a decrease of both CD4 and CD8 expression at the cell surface level and at the mRNA level in a CD4+ CD8+ T cell line and in freshly isolated thymocytes.	Tetradecanoylphorbol Acetate	88-91	CD8a molecule	Homo sapiens	200-203
8384354-1	1993	Expression of immediate-early genes involving the 12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive element (TRE) is modulated by post-translational modification of pre-existing activator protein 1 (AP-1) constituents.	Tetradecanoylphorbol Acetate	50-87	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	183-202
8384354-1	1993	Expression of immediate-early genes involving the 12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive element (TRE) is modulated by post-translational modification of pre-existing activator protein 1 (AP-1) constituents.	Tetradecanoylphorbol Acetate	50-87	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	204-208
8383965-1	1993	Incubation of human polymorphonuclear leucocytes (PMN) with either the chemotactic factor N-formylmethionyl-leucylphenylalanine (FMLP) or phorbol 12-myristate 13-acetate (PMA) activates a kinase with phosphorylating activity towards a known microtubule-associated protein-2 (MAP) kinase substrate, the epidermal growth factor receptor peptide (T669).	Tetradecanoylphorbol Acetate	138-169	microtubule associated protein 2	Homo sapiens	241-273
8383965-1	1993	Incubation of human polymorphonuclear leucocytes (PMN) with either the chemotactic factor N-formylmethionyl-leucylphenylalanine (FMLP) or phorbol 12-myristate 13-acetate (PMA) activates a kinase with phosphorylating activity towards a known microtubule-associated protein-2 (MAP) kinase substrate, the epidermal growth factor receptor peptide (T669).	Tetradecanoylphorbol Acetate	138-169	microtubule associated protein 2	Homo sapiens	275-278
8096435-4	1993	Identical to phorbol 12-myristate 13-acetate (PMA)-induced clustering, CD45-mediated aggregation was also suppressed by EDTA, by cytochalasin B, and by incubation at 4 degrees C, all characteristics of adhesion mediated by integrins.	Tetradecanoylphorbol Acetate	13-44	protein tyrosine phosphatase receptor type C	Homo sapiens	71-75
8096435-4	1993	Identical to phorbol 12-myristate 13-acetate (PMA)-induced clustering, CD45-mediated aggregation was also suppressed by EDTA, by cytochalasin B, and by incubation at 4 degrees C, all characteristics of adhesion mediated by integrins.	Tetradecanoylphorbol Acetate	46-49	protein tyrosine phosphatase receptor type C	Homo sapiens	71-75
8095965-4	1993	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) induced release of ECP in a dose-dependent fashion but 4-alpha-PMA, an analogue that does not activate protein kinase C, did not cause degranulation.	Tetradecanoylphorbol Acetate	31-62	ribonuclease A family member 3	Homo sapiens	88-91
8095965-4	1993	The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) induced release of ECP in a dose-dependent fashion but 4-alpha-PMA, an analogue that does not activate protein kinase C, did not cause degranulation.	Tetradecanoylphorbol Acetate	64-67	ribonuclease A family member 3	Homo sapiens	88-91
8095965-11	1993	In conclusion, PMA induces release of ECP from single adherent eosinophils and the effect appears to be mediated via protein kinase C and, in contrast to that in neutrophils, to be dependent on CD11/CD18 leukocyte integrins.	Tetradecanoylphorbol Acetate	15-18	ribonuclease A family member 3	Homo sapiens	38-41
8487592-3	1993	An estimation was made of the 50% inhibitory concentration (IC50) of mesna and NAC for PMA-induced H2O2 production by human neutrophils, the results being 70 mcM and 77 mcM, respectively.	Tetradecanoylphorbol Acetate	87-90	methylmalonyl-CoA mutase	Homo sapiens	158-161
8487592-3	1993	An estimation was made of the 50% inhibitory concentration (IC50) of mesna and NAC for PMA-induced H2O2 production by human neutrophils, the results being 70 mcM and 77 mcM, respectively.	Tetradecanoylphorbol Acetate	87-90	methylmalonyl-CoA mutase	Homo sapiens	169-172
8442767-7	1993	The finding that induction of c-jun expression by ethanol was inhibited by the isoquinolinesulfonamide derivative H7, but not by HA1004, suggested that this effect is mediated by protein kinase C. Furthermore, down-regulation of protein kinase C by prolonged exposure to 12-O-tetradecanoylphorbol-13-acetate was associated with a block in ethanol-induced c-jun expression.	Tetradecanoylphorbol Acetate	271-307	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-35
8426742-11	1993	We conclude that Raf-1 signaling is essential for transformation of NIH/3T3 cells by peripheral oncogenes and for regulation of a subset of early response genes by TPA and serum growth factors.	Tetradecanoylphorbol Acetate	164-167	v-raf-leukemia viral oncogene 1	Mus musculus	17-22
8421910-7	1993	We also observed that the detectable levels of p37 and p50 in the infected MOLT-4 cells were greatly reduced after phorbol ester (TPA) treatment under the condition of which HIV-1 gene expression was increased by about fivefold.	Tetradecanoylphorbol Acetate	130-133	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	47-50
7681292-5	1993	Previous studies have suggested that the induction of K13 in mouse skin is related to the mutation of the Ha-ras gene by the initiating agent DMBA, a mutation consistently found in murine DMBA/TPA-induced tumors and rarely found in human skin tumors.	Tetradecanoylphorbol Acetate	193-196	Harvey rat sarcoma virus oncogene	Mus musculus	106-112
8346079-11	1993	However, TPA induction of ornithine decarboxylase activity did not appear to be significantly modified by dietary linoleate.	Tetradecanoylphorbol Acetate	9-12	ornithine decarboxylase, structural 1	Mus musculus	26-49
8356391-4	1993	Subcultured synovial fibroblasts, devoid of macrophages, did not produce MMP-9 as judged by zymography and immunolocalisation; but when stimulated with phorbol myristate acetate and interleukin-1 alpha both MMP-9 and MMP-3 were co-expressed.	Tetradecanoylphorbol Acetate	152-177	matrix metallopeptidase 9	Homo sapiens	207-212
28373608-8	2017	Quercetin suppressed PMA-induced phosphorylation of Tyr311 of PKCdelta in isolated islets.	Tetradecanoylphorbol Acetate	21-24	protein kinase C, delta	Mus musculus	62-70
28123548-0	2017	DHA blocks TPA-induced cell invasion by inhibiting MMP-9 expression via suppression of the PPAR-gamma/NF-kappaB pathway in MCF-7 cells.	Tetradecanoylphorbol Acetate	11-14	matrix metallopeptidase 9	Homo sapiens	51-56
28123548-4	2017	The present study investigated the inhibitory effect of DHA on MMP-9 expression and cell invasion induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the MCF-7 breast cancer cell line.	Tetradecanoylphorbol Acetate	109-145	matrix metallopeptidase 9	Homo sapiens	63-68
28123548-4	2017	The present study investigated the inhibitory effect of DHA on MMP-9 expression and cell invasion induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the MCF-7 breast cancer cell line.	Tetradecanoylphorbol Acetate	147-150	matrix metallopeptidase 9	Homo sapiens	63-68
27333995-7	2016	HE treatment had reduced the mouse skin oedema (47%) and myeloperoxidase (MPO) activity significantly (40%) in TPA-challenged tissues.	Tetradecanoylphorbol Acetate	111-114	myeloperoxidase	Mus musculus	57-72
27333995-7	2016	HE treatment had reduced the mouse skin oedema (47%) and myeloperoxidase (MPO) activity significantly (40%) in TPA-challenged tissues.	Tetradecanoylphorbol Acetate	111-114	myeloperoxidase	Mus musculus	74-77
27599715-2	2016	We here report that stimulation of lung epithelial A549 tumor cells with phorbol-12-myristate-13-acetate (PMA) leads to the downregulation of the surface expressed mature form of ADAM17 without affecting ADAM10 expression.	Tetradecanoylphorbol Acetate	73-104	ADAM metallopeptidase domain 17	Homo sapiens	179-185
27599715-2	2016	We here report that stimulation of lung epithelial A549 tumor cells with phorbol-12-myristate-13-acetate (PMA) leads to the downregulation of the surface expressed mature form of ADAM17 without affecting ADAM10 expression.	Tetradecanoylphorbol Acetate	106-109	ADAM metallopeptidase domain 17	Homo sapiens	179-185
27731361-9	2016	Our results therefore imply that physiological activation of ADAM17 does not rely on its relocalisation, but that PMA-induced PKC activity drastically dysregulates the localisation of ADAM17.	Tetradecanoylphorbol Acetate	114-117	ADAM metallopeptidase domain 17	Homo sapiens	184-190
27109393-6	2016	Tissue plasminogen activator levels (tPA) were significantly lower in the cases (p &lt; 0.001) but Plasminogen activator inhibitor type 1 (PAI-1) values were comparable.	Tetradecanoylphorbol Acetate	37-40	chromosome 20 open reading frame 181	Homo sapiens	0-28
27492945-1	2016	The decision to administer intravenous tissue plasminogen activator (IV tPA) is based on standard exclusion and inclusion criteria, which include laboratories, imaging, and time of last known well.	Tetradecanoylphorbol Acetate	72-75	chromosome 20 open reading frame 181	Homo sapiens	39-67
27534378-6	2016	Results using both functionals agree that the RFP-derived model of the Gold Fluorescent Protein chromophore (Model 20) has the largest intrinsic TPA cross-section at the optimized geometry.	Tetradecanoylphorbol Acetate	145-148	tripartite motif containing 27	Homo sapiens	46-49
27466416-6	2016	Overexpression of IFI16 reduced lytic gene induction by the chemical agent 12-O-tetradecoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	111-114	interferon gamma inducible protein 16	Homo sapiens	18-23
27466416-7	2016	IFI16 protein levels were significantly reduced or absent in TPA- or doxycycline-induced cells expressing lytic KSHV proteins.	Tetradecanoylphorbol Acetate	61-64	interferon gamma inducible protein 16	Homo sapiens	0-5
27339895-7	2016	By time-lapse FRET microscopy, IkappaBalpha ERK WWOX complex exhibits an increased binding strength by 1-2-fold after exposure to ionophore A23187/phorbol myristate acetate for 15-24 h. Meanwhile, a portion of ERK and WWOX relocates to the nucleus, suggesting their role in the induction of CD3 and CD8 expression in MOLT-4.	Tetradecanoylphorbol Acetate	147-172	CD8a molecule	Homo sapiens	299-302
27409664-6	2016	Furthermore, downregulation of CTBP1 by miR-644a upregulates wild type- or mutant-p53 which acts as a "molecular switch" between G1-arrest and apoptosis by inducing cyclin-dependent kinase inhibitor 1 (p21, CDKN1A, CIP1) or pro-apoptotic phorbol-12-myristate-13-acetate-induced protein 1 (Noxa, PMAIP1), respectively.	Tetradecanoylphorbol Acetate	238-269	microRNA 644a	Homo sapiens	40-48
27035791-6	2016	Rev-AuNPs suppressed TPA-induced enzymatic activity and the expression of matrix metalloproteinase (MMP)-9 and cyclooxygenase-2 (COX-2).	Tetradecanoylphorbol Acetate	21-24	matrix metallopeptidase 9	Homo sapiens	74-106
27243897-2	2016	The goal of our current study was to reveal the relationship between Rac1/NADPH pathway and radiosensitization in CNE-1 cells using Rac1 activator, phorbol 12-myristate 13-acetate (PMA) and Rac1 inhibitor NSC23766.	Tetradecanoylphorbol Acetate	148-179	Rac family small GTPase 1	Homo sapiens	69-73
27243897-2	2016	The goal of our current study was to reveal the relationship between Rac1/NADPH pathway and radiosensitization in CNE-1 cells using Rac1 activator, phorbol 12-myristate 13-acetate (PMA) and Rac1 inhibitor NSC23766.	Tetradecanoylphorbol Acetate	181-184	Rac family small GTPase 1	Homo sapiens	69-73
27105502-8	2016	The in vitro study showed that MALT1 inhibitors decreased production of IL-1beta/IL-18 in phorbol myristate acetate-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome.	Tetradecanoylphorbol Acetate	90-115	interleukin 18	Homo sapiens	81-86
27074999-2	2016	For estimating the physical entrapment effect, the best glucose oxidase (GOx) concentration immobilized on polyethyleneimine (PEI) and carbon nanotube (CNT) (GOx/PEI/CNT) was determined, while for inspecting the chemical bonding effect, terephthalaldehyde (TPA) and glutaraldehyde (GA) crosslinkers were employed.	Tetradecanoylphorbol Acetate	257-260	hydroxyacid oxidase 1	Homo sapiens	73-76
27074999-3	2016	According to the enzyme activity and XPS measurements, when the GOx concentration is 4 mg mL(-1), they are most effectively immobilized (via the physical entrapment effect) and TPA-crosslinked GOx/PEI/CNT(TPA/[GOx/PEI/CNT]) forms pi conjugated bonds via chemical bonding, inducing the promotion of electron transfer by delocalization of electrons.	Tetradecanoylphorbol Acetate	177-180	hydroxyacid oxidase 1	Homo sapiens	64-67
27074999-3	2016	According to the enzyme activity and XPS measurements, when the GOx concentration is 4 mg mL(-1), they are most effectively immobilized (via the physical entrapment effect) and TPA-crosslinked GOx/PEI/CNT(TPA/[GOx/PEI/CNT]) forms pi conjugated bonds via chemical bonding, inducing the promotion of electron transfer by delocalization of electrons.	Tetradecanoylphorbol Acetate	177-180	hydroxyacid oxidase 1	Homo sapiens	193-196
27011169-5	2016	Our results showed significantly accelerated biodegradation of ox-SWCNTs and OH-SWCNTs in macrophages activated by phorbol myristate acetate (PMA), which could be prevented by N-acetyl-l-cysteine (NAC), whereas p-SWCNTs were resistant to biodegradation.	Tetradecanoylphorbol Acetate	115-140	X-linked Kx blood group	Homo sapiens	197-200
27011169-5	2016	Our results showed significantly accelerated biodegradation of ox-SWCNTs and OH-SWCNTs in macrophages activated by phorbol myristate acetate (PMA), which could be prevented by N-acetyl-l-cysteine (NAC), whereas p-SWCNTs were resistant to biodegradation.	Tetradecanoylphorbol Acetate	142-145	X-linked Kx blood group	Homo sapiens	197-200
26786102-3	2016	Here we show that androgens (5alpha-dihydrotestosterone and R1881) suppress c-Fos protein and mRNA expression induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) or EGF in human prostate cancer (PCa) cell lines.	Tetradecanoylphorbol Acetate	121-157	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-81
26786102-3	2016	Here we show that androgens (5alpha-dihydrotestosterone and R1881) suppress c-Fos protein and mRNA expression induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) or EGF in human prostate cancer (PCa) cell lines.	Tetradecanoylphorbol Acetate	159-162	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-81
26786102-5	2016	We show that androgen signaling suppresses TPA-induced c-Fos expression through repressing a PKC/MEK/ERK/ELK-1 signaling pathway.	Tetradecanoylphorbol Acetate	43-46	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-60
26786102-5	2016	We show that androgen signaling suppresses TPA-induced c-Fos expression through repressing a PKC/MEK/ERK/ELK-1 signaling pathway.	Tetradecanoylphorbol Acetate	43-46	ETS transcription factor ELK1	Homo sapiens	105-110
26786102-10	2016	Acquisition of androgen-independent killing by TPA correlates with activation of p38(MAPK), suppression of ERK1/2, and loss of c-Fos.	Tetradecanoylphorbol Acetate	47-50	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	127-132
26679069-1	2016	BACKGROUND: Obtaining a routine computed tomography (CT) brain scan 24 hours after treatment with intravenous tissue plasminogen activator (IV-tPA) is included in the American Heart Association/American Stroke Association acute stroke guidelines.	Tetradecanoylphorbol Acetate	143-146	chromosome 20 open reading frame 181	Homo sapiens	110-138
26848699-5	2016	Although Snail family factors have been linked to inflammation via interactions with the cyclooxygenase-2 (COX-2) pathway, a pathway that also plays an important role in skin carcinogenesis, transient TPA induction of Slug and Snail appeared unrelated to COX-2 expression.	Tetradecanoylphorbol Acetate	201-204	snail family zinc finger 1	Mus musculus	227-232
26848699-6	2016	In cultured human keratinocytes, TPA induced Snail mRNA expression while suppressing Slug expression, and this differential regulation was due specifically to activation of the TPA receptor.	Tetradecanoylphorbol Acetate	33-36	snail family transcriptional repressor 2	Homo sapiens	85-89
26796274-6	2016	Moreover, the loss of epithelial markers, including E-cadherin and GATA-3, suggested that chronic exposure of TPA stimulates EMT.	Tetradecanoylphorbol Acetate	110-113	GATA binding protein 3	Homo sapiens	67-73
26667493-2	2016	For this purpose, new terephthalaldehyde (TPA) and conventional glutaraldehyde (GA) cross-linkers are adopted on a glucose oxidase (GOx), polyethyleneimine (PEI) and carbon nanotube (CNT)(GOx/PEI/CNT) structure.	Tetradecanoylphorbol Acetate	42-45	hydroxyacid oxidase 1	Homo sapiens	115-130
26667493-2	2016	For this purpose, new terephthalaldehyde (TPA) and conventional glutaraldehyde (GA) cross-linkers are adopted on a glucose oxidase (GOx), polyethyleneimine (PEI) and carbon nanotube (CNT)(GOx/PEI/CNT) structure.	Tetradecanoylphorbol Acetate	42-45	hydroxyacid oxidase 1	Homo sapiens	132-135
26667493-2	2016	For this purpose, new terephthalaldehyde (TPA) and conventional glutaraldehyde (GA) cross-linkers are adopted on a glucose oxidase (GOx), polyethyleneimine (PEI) and carbon nanotube (CNT)(GOx/PEI/CNT) structure.	Tetradecanoylphorbol Acetate	42-45	hydroxyacid oxidase 1	Homo sapiens	188-191
26667493-3	2016	GOx/PEI/CNT cross-linked by TPA (TPA/[GOx/PEI/CNT]) results in a superior EBC performance and stability to other catalysts.	Tetradecanoylphorbol Acetate	28-31	hydroxyacid oxidase 1	Homo sapiens	0-3
26667493-3	2016	GOx/PEI/CNT cross-linked by TPA (TPA/[GOx/PEI/CNT]) results in a superior EBC performance and stability to other catalysts.	Tetradecanoylphorbol Acetate	28-31	hydroxyacid oxidase 1	Homo sapiens	38-41
26667493-3	2016	GOx/PEI/CNT cross-linked by TPA (TPA/[GOx/PEI/CNT]) results in a superior EBC performance and stability to other catalysts.	Tetradecanoylphorbol Acetate	33-36	hydroxyacid oxidase 1	Homo sapiens	0-3
26667493-3	2016	GOx/PEI/CNT cross-linked by TPA (TPA/[GOx/PEI/CNT]) results in a superior EBC performance and stability to other catalysts.	Tetradecanoylphorbol Acetate	33-36	hydroxyacid oxidase 1	Homo sapiens	38-41
26667493-4	2016	It is attributed to the pi bonds conjugated between the aldehyde of TPA and amine of the GOx/PEI molecules.	Tetradecanoylphorbol Acetate	68-71	hydroxyacid oxidase 1	Homo sapiens	89-92
26667493-6	2016	The maximum power density (MPD) of an EBC adopting TPA/[GOx/PEI/CNT] (0.66 mW cm(-2)) is far better than that of the other EBCs (the MPD of EBC adopting GOx/PEI/CNT is 0.40 mW cm(-2)).	Tetradecanoylphorbol Acetate	51-54	hydroxyacid oxidase 1	Homo sapiens	56-59
26667493-6	2016	The maximum power density (MPD) of an EBC adopting TPA/[GOx/PEI/CNT] (0.66 mW cm(-2)) is far better than that of the other EBCs (the MPD of EBC adopting GOx/PEI/CNT is 0.40 mW cm(-2)).	Tetradecanoylphorbol Acetate	51-54	hydroxyacid oxidase 1	Homo sapiens	153-156
26667493-7	2016	Regarding stability, the covalent bonding formed between TPA and GOx/PEI plays a critical role in preventing the denaturation of GOx molecules, leading to an excellent stability.	Tetradecanoylphorbol Acetate	57-60	hydroxyacid oxidase 1	Homo sapiens	65-68
26667493-7	2016	Regarding stability, the covalent bonding formed between TPA and GOx/PEI plays a critical role in preventing the denaturation of GOx molecules, leading to an excellent stability.	Tetradecanoylphorbol Acetate	57-60	hydroxyacid oxidase 1	Homo sapiens	129-132
26667493-8	2016	By repeated measurements of the catalytic activity, TPA/[GOx/PEI/CNT] maintains its activity to 92% of its initial value even after five weeks.	Tetradecanoylphorbol Acetate	52-55	hydroxyacid oxidase 1	Homo sapiens	57-60
26494252-7	2016	Addition of phorbol 12-myristate 13-acetate increased Erk activity leading to suppression of gstp1-2 mRNA.	Tetradecanoylphorbol Acetate	12-43	glutathione S-transferase pi 1.2	Danio rerio	93-100
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	41-72	ATP binding cassette subfamily B member 11	Homo sapiens	339-343
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	41-72	ATP binding cassette subfamily C member 2	Homo sapiens	348-352
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	74-77	ATP binding cassette subfamily B member 11	Homo sapiens	339-343
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	74-77	ATP binding cassette subfamily C member 2	Homo sapiens	348-352
26475020-5	2015	During phorbol myristate acetate (PMA)-activation of HDLECs, miR-132 is induced in a CREB-dependent manner and inhibition of miR-132 results in increased AGO2 expression.	Tetradecanoylphorbol Acetate	7-32	cAMP responsive element binding protein 1	Homo sapiens	85-89
26475020-5	2015	During phorbol myristate acetate (PMA)-activation of HDLECs, miR-132 is induced in a CREB-dependent manner and inhibition of miR-132 results in increased AGO2 expression.	Tetradecanoylphorbol Acetate	34-37	cAMP responsive element binding protein 1	Homo sapiens	85-89
26397194-5	2015	The inhibitory effects of ITCs on PMA-induced MMP-9 expression were found to be associated with the inhibition of MMP-9 transcription levels through suppression of nuclear translocation of NF-kappaB and activator protein-1 (AP-1).	Tetradecanoylphorbol Acetate	34-37	matrix metallopeptidase 9	Homo sapiens	46-51
26397194-5	2015	The inhibitory effects of ITCs on PMA-induced MMP-9 expression were found to be associated with the inhibition of MMP-9 transcription levels through suppression of nuclear translocation of NF-kappaB and activator protein-1 (AP-1).	Tetradecanoylphorbol Acetate	34-37	matrix metallopeptidase 9	Homo sapiens	114-119
26319521-5	2015	At the same time, the results showed that infected mouse splenic NK cells expressed increased levels of CD25 and CD69 and produced more IL-2, IL-4, and IL-17 and less IFN-gamma after stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	200-203	interleukin 2 receptor, alpha chain	Mus musculus	104-108
26319521-5	2015	At the same time, the results showed that infected mouse splenic NK cells expressed increased levels of CD25 and CD69 and produced more IL-2, IL-4, and IL-17 and less IFN-gamma after stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	200-203	interleukin 17A	Mus musculus	152-157
26608825-5	2015	In HT1080 cells, TSG101 depletion increased both baseline and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion through enhancing MMP-9 mRNA expression, but did not affect the expression or activation of MMP-2.	Tetradecanoylphorbol Acetate	62-93	matrix metallopeptidase 9	Homo sapiens	108-113
26608825-5	2015	In HT1080 cells, TSG101 depletion increased both baseline and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion through enhancing MMP-9 mRNA expression, but did not affect the expression or activation of MMP-2.	Tetradecanoylphorbol Acetate	95-98	matrix metallopeptidase 9	Homo sapiens	108-113
26459397-9	2015	In conclusion, repeated intra-nigrostriatal treatment with PMA induced microglial senescence with increased expression levels of beta-galactosidase and p21 in the substantia nigra of the rats.	Tetradecanoylphorbol Acetate	59-62	KRAS proto-oncogene, GTPase	Rattus norvegicus	152-155
26486958-10	2015	Accordingly, IL-22 mRNA half-life as determined in TPA/A23187-stimulated Jurkat T cells decreased under the influence of the MEK1/2 inhibitor U0126.	Tetradecanoylphorbol Acetate	51-54	interleukin 22	Homo sapiens	13-18
26343458-3	2015	In addition to these elements, we previously identified a TPA-responsive element (TRE) in the hepcidin promoter and showed that it mediated the transcriptional activation of hepcidin through activator protein (AP)-1 induced by serum.	Tetradecanoylphorbol Acetate	58-61	tRNA-Glu (anticodon TTC) 3-1	Homo sapiens	82-85
26473723-3	2015	Phorbol myristate acetate markedly inhibited LPA1- and LPA3-mediated effect, whereas that mediated by LPA2 was only partially diminished; the actions of the phorbol ester were inhibited by bisindolylmaleimide I and by overnight incubation with the protein kinase C activator, which leads to down regulation of this protein kinase.	Tetradecanoylphorbol Acetate	0-25	lysophosphatidic acid receptor 1	Homo sapiens	45-49
26473723-6	2015	Lysophosphatidic acid and phorbol myristate acetate were able to induce LPA1-3 phosphorylation, in time- and concentration-dependent fashions.	Tetradecanoylphorbol Acetate	26-51	lysophosphatidic acid receptor 1	Homo sapiens	72-76
26101063-0	2015	Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways.	Tetradecanoylphorbol Acetate	18-21	matrix metallopeptidase 9	Homo sapiens	66-92
26101063-4	2015	Matrix metalloproteinase (MMP)-9 is a major component facilitating the invasion of many cancer tumor cell types, and thus the inhibitory effect of fisetin on MMP-9 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated human breast cancer cells was investigated in this study.	Tetradecanoylphorbol Acetate	178-214	matrix metallopeptidase 9	Homo sapiens	158-163
26101063-4	2015	Matrix metalloproteinase (MMP)-9 is a major component facilitating the invasion of many cancer tumor cell types, and thus the inhibitory effect of fisetin on MMP-9 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated human breast cancer cells was investigated in this study.	Tetradecanoylphorbol Acetate	216-219	matrix metallopeptidase 9	Homo sapiens	0-32
26049101-2	2015	Following 20 weeks of promotion with TPA the Cyp 1b1 null mice, initiated with DBC, exhibited reductions in incidence, multiplicity, and progression.	Tetradecanoylphorbol Acetate	37-40	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	45-52
26044736-6	2015	Moreover, the inhibition of Aurora kinases by their siRNAs and inhibitors suppressed TPA-induced cell invasion and expression of MMP-9 by inhibiting the activation of NF-kappaB/AP-1, major transcription factors for MMP-9 expression in MCF-7 cells.	Tetradecanoylphorbol Acetate	85-88	matrix metallopeptidase 9	Homo sapiens	129-134
26044736-6	2015	Moreover, the inhibition of Aurora kinases by their siRNAs and inhibitors suppressed TPA-induced cell invasion and expression of MMP-9 by inhibiting the activation of NF-kappaB/AP-1, major transcription factors for MMP-9 expression in MCF-7 cells.	Tetradecanoylphorbol Acetate	85-88	matrix metallopeptidase 9	Homo sapiens	215-220
26211738-4	2015	Here, we show the first characterization of Cdr1as expression in islet cells, which was upregulated by long-term forskolin and PMA stimulation, but not high glucose, indicating the involvement of cAMP and PKC pathways.	Tetradecanoylphorbol Acetate	127-130	CDR1 antisense RNA	Homo sapiens	44-50
25997494-9	2015	On gelatinase zymography, SK-Hep-1 showed bands corresponding to MMP-2 and MMP-9 with enhancement of MMP-9 with PMA (100 ng/ml) treatment.	Tetradecanoylphorbol Acetate	112-115	matrix metallopeptidase 9	Homo sapiens	101-106
26171065-0	2015	Hispolon inhibits TPA-induced invasion by reducing MMP-9 expression through the NF-kappaB signaling pathway in MDA-MB-231 human breast cancer cells.	Tetradecanoylphorbol Acetate	18-21	matrix metallopeptidase 9	Homo sapiens	51-56
26171065-5	2015	Hispolon also prevented the TPA-induced secretion of matrix metalloproteinase-9 (MMP-9) and reduced its expression at the transcriptional and translational levels.	Tetradecanoylphorbol Acetate	28-31	matrix metallopeptidase 9	Homo sapiens	53-79
26171065-5	2015	Hispolon also prevented the TPA-induced secretion of matrix metalloproteinase-9 (MMP-9) and reduced its expression at the transcriptional and translational levels.	Tetradecanoylphorbol Acetate	28-31	matrix metallopeptidase 9	Homo sapiens	81-86
26171065-9	2015	In conclusion, the results of the present study indicated that hispolon inhibited TPA-induced migration and invasion of MDA-MB-231 cells by reducing the secretion and expression of MMP-9 through the NF-kappaB signaling pathway.	Tetradecanoylphorbol Acetate	82-85	matrix metallopeptidase 9	Homo sapiens	181-186
26116564-8	2015	Treatment of HT29 and Caco-2 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced an invasive phenotype response along with corresponding increases in ROS production and NOX2 and MMP-7 expression as well as reduced AMPK phosphorylation, which resemble basal conditions of highly invasive human colon cancer cells (SW620 and HCT116).	Tetradecanoylphorbol Acetate	40-76	cytochrome b-245 beta chain	Homo sapiens	179-183
26116564-8	2015	Treatment of HT29 and Caco-2 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced an invasive phenotype response along with corresponding increases in ROS production and NOX2 and MMP-7 expression as well as reduced AMPK phosphorylation, which resemble basal conditions of highly invasive human colon cancer cells (SW620 and HCT116).	Tetradecanoylphorbol Acetate	78-81	cytochrome b-245 beta chain	Homo sapiens	179-183
26116564-12	2015	TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors.	Tetradecanoylphorbol Acetate	0-3	neutrophil cytosolic factor 1	Homo sapiens	177-184
26116564-12	2015	TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors.	Tetradecanoylphorbol Acetate	126-129	cytochrome b-245 beta chain	Homo sapiens	152-156
26116564-12	2015	TPA-induced induction of MMP-7 expression was suppressed by AP-1, NF-kappaB, and MAPK (ERK, p38, and JNK) inhibitors, whereas TPA-induced expression of NOX2 and its regulators, p47phox and p67phox, was blocked by p38 and NF-kappaB inhibitors.	Tetradecanoylphorbol Acetate	126-129	neutrophil cytosolic factor 1	Homo sapiens	177-184
26137162-0	2015	Failure of matrix metalloproteinase-9 dimer induction by phorbol 12-myristate 13-acetate in normal human cell lines.	Tetradecanoylphorbol Acetate	57-88	matrix metallopeptidase 9	Homo sapiens	11-37
26137162-8	2015	The aim of the present study was to analyze the expression patterns of MMP-2, MMP-9 and MMP-9 dimer in normal human cells from a number of tissues treated with PMA.	Tetradecanoylphorbol Acetate	160-163	matrix metallopeptidase 9	Homo sapiens	78-83
26137162-8	2015	The aim of the present study was to analyze the expression patterns of MMP-2, MMP-9 and MMP-9 dimer in normal human cells from a number of tissues treated with PMA.	Tetradecanoylphorbol Acetate	160-163	matrix metallopeptidase 9	Homo sapiens	88-93
25948100-5	2015	The levels of interferon-gamma (IFN-gamma) and interleukin-17 (IL-17) secreted by T cells stimulated with PMA and ionomycin were also determined by flow cytometry.	Tetradecanoylphorbol Acetate	106-109	interleukin 17A	Homo sapiens	47-61
25948100-5	2015	The levels of interferon-gamma (IFN-gamma) and interleukin-17 (IL-17) secreted by T cells stimulated with PMA and ionomycin were also determined by flow cytometry.	Tetradecanoylphorbol Acetate	106-109	interleukin 17A	Homo sapiens	63-68
25912851-9	2015	alpha-Asarone increased the expression levels of MMP-2 and MMP-9 stimulated by phenazine methosulfate (PMS) and phorbol 12-myristate 13-acetate (PMA) in HT1080.	Tetradecanoylphorbol Acetate	112-143	matrix metallopeptidase 9	Homo sapiens	59-64
25912851-9	2015	alpha-Asarone increased the expression levels of MMP-2 and MMP-9 stimulated by phenazine methosulfate (PMS) and phorbol 12-myristate 13-acetate (PMA) in HT1080.	Tetradecanoylphorbol Acetate	145-148	matrix metallopeptidase 9	Homo sapiens	59-64
25652588-4	2015	We show here that activation or overexpression of constitutively active merlin or downregulation of ERMs inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced [as well as serum, hepatocyte growth factor (HGF), or platelet-derived growth factor (PDGF)] CD44 cleavage by the metalloprotease ADAM10, whereas overexpressed ERM proteins promoted cleavage.	Tetradecanoylphorbol Acetate	115-151	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	72-78
25652588-4	2015	We show here that activation or overexpression of constitutively active merlin or downregulation of ERMs inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced [as well as serum, hepatocyte growth factor (HGF), or platelet-derived growth factor (PDGF)] CD44 cleavage by the metalloprotease ADAM10, whereas overexpressed ERM proteins promoted cleavage.	Tetradecanoylphorbol Acetate	115-151	CD44 molecule (Indian blood group)	Homo sapiens	259-263
25652588-4	2015	We show here that activation or overexpression of constitutively active merlin or downregulation of ERMs inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced [as well as serum, hepatocyte growth factor (HGF), or platelet-derived growth factor (PDGF)] CD44 cleavage by the metalloprotease ADAM10, whereas overexpressed ERM proteins promoted cleavage.	Tetradecanoylphorbol Acetate	153-156	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	72-78
25652588-4	2015	We show here that activation or overexpression of constitutively active merlin or downregulation of ERMs inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced [as well as serum, hepatocyte growth factor (HGF), or platelet-derived growth factor (PDGF)] CD44 cleavage by the metalloprotease ADAM10, whereas overexpressed ERM proteins promoted cleavage.	Tetradecanoylphorbol Acetate	153-156	CD44 molecule (Indian blood group)	Homo sapiens	259-263
25915860-0	2015	12-O-Tetradecanoylphorbol-13-Acetate Induces Up-Regulated Transcription of Variant 1 but Not Variant 2 of VIL2 in Esophageal Squamous Cell Carcinoma Cells via ERK1/2/AP-1/Sp1 Signaling.	Tetradecanoylphorbol Acetate	0-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	166-170
25915860-7	2015	AP-1 and Sp1 binding sites within the promoter region of VIL2 V1 acted not only as basal transcriptional elements but also as a composite TPA-responsive element (TRE) for the transcription of VIL2 V1.	Tetradecanoylphorbol Acetate	138-141	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
25915860-8	2015	TPA stimulation enhanced c-Jun and Sp1 binding to the TRE via activation of the ERK1/2 pathway and increased protein levels of c-Jun, c-Fos, and Sp1, resulting in over-expression of VIL2 V1, whereas the MEK1/2 inhibitor U0126 blocked these events.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-30
25915860-8	2015	TPA stimulation enhanced c-Jun and Sp1 binding to the TRE via activation of the ERK1/2 pathway and increased protein levels of c-Jun, c-Fos, and Sp1, resulting in over-expression of VIL2 V1, whereas the MEK1/2 inhibitor U0126 blocked these events.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	127-132
25915860-8	2015	TPA stimulation enhanced c-Jun and Sp1 binding to the TRE via activation of the ERK1/2 pathway and increased protein levels of c-Jun, c-Fos, and Sp1, resulting in over-expression of VIL2 V1, whereas the MEK1/2 inhibitor U0126 blocked these events.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-139
25915860-10	2015	Taken together, these results suggest that TPA is able to induce VIL2 V1 over-expression in ESCC cells by activating MEK/ERK1/2 signaling and increasing binding of Sp1 and c-Jun to the TRE of the VIL2 V1 promoter, and that VIL2 is an important TPA-induced effector.	Tetradecanoylphorbol Acetate	43-46	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-177
25765655-4	2015	We found that increased expression of G9a along with transcription factor YY1 specifically represses UHRF1 transcription during TPA-mediated leukemia cell differentiation.	Tetradecanoylphorbol Acetate	128-131	euchromatic histone lysine methyltransferase 2	Homo sapiens	38-41
25765655-4	2015	We found that increased expression of G9a along with transcription factor YY1 specifically represses UHRF1 transcription during TPA-mediated leukemia cell differentiation.	Tetradecanoylphorbol Acetate	128-131	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	101-106
25682767-0	2015	Curcumin relieves TPA-induced Th1 inflammation in K14-VEGF transgenic mice.	Tetradecanoylphorbol Acetate	18-21	vascular endothelial growth factor A	Mus musculus	54-58
25348263-1	2015	We explored the interplay between the intracellular energy sensor AMP-activated protein kinase (AMPK), extracellular signal-regulated kinase (ERK), and autophagy in phorbol myristate acetate (PMA)-induced neuronal differentiation of SH-SY5Y human neuroblastoma cells.	Tetradecanoylphorbol Acetate	192-195	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	66-94
25348263-1	2015	We explored the interplay between the intracellular energy sensor AMP-activated protein kinase (AMPK), extracellular signal-regulated kinase (ERK), and autophagy in phorbol myristate acetate (PMA)-induced neuronal differentiation of SH-SY5Y human neuroblastoma cells.	Tetradecanoylphorbol Acetate	192-195	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	96-100
25348263-7	2015	Therefore, PMA-induced neuronal differentiation of SH-SY5Y cells depends on a complex interplay between AMPK, ERK, and autophagy, in which the stimulatory effects of AMPK/ERK signaling are counteracted by the coinciding autophagic response.	Tetradecanoylphorbol Acetate	11-14	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	104-108
25348263-7	2015	Therefore, PMA-induced neuronal differentiation of SH-SY5Y cells depends on a complex interplay between AMPK, ERK, and autophagy, in which the stimulatory effects of AMPK/ERK signaling are counteracted by the coinciding autophagic response.	Tetradecanoylphorbol Acetate	11-14	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	166-170
25348263-8	2015	Phorbol myristate acetate (PMA) induces the expression of dopamine transporter, microtubule-associated protein 2, and beta-tubulin, and subsequent neuronal differentiation of SH-SY5Y neuroblastoma cells through AMP-activated protein kinase (AMPK)-dependent activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	0-25	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	211-239
25348263-8	2015	Phorbol myristate acetate (PMA) induces the expression of dopamine transporter, microtubule-associated protein 2, and beta-tubulin, and subsequent neuronal differentiation of SH-SY5Y neuroblastoma cells through AMP-activated protein kinase (AMPK)-dependent activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	0-25	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	241-245
25348263-8	2015	Phorbol myristate acetate (PMA) induces the expression of dopamine transporter, microtubule-associated protein 2, and beta-tubulin, and subsequent neuronal differentiation of SH-SY5Y neuroblastoma cells through AMP-activated protein kinase (AMPK)-dependent activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	27-30	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	211-239
25348263-8	2015	Phorbol myristate acetate (PMA) induces the expression of dopamine transporter, microtubule-associated protein 2, and beta-tubulin, and subsequent neuronal differentiation of SH-SY5Y neuroblastoma cells through AMP-activated protein kinase (AMPK)-dependent activation of extracellular signal-regulated kinase (ERK).	Tetradecanoylphorbol Acetate	27-30	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	241-245
25583575-5	2015	In addition, these isoflavones potently enhanced Il17a mRNA expression in mouse T lymphoma EL4 cells treated with phorbol myristate acetate and ionomycin, but showed slight enhancement of Il17a gene expression in RORalpha/gamma-knockdown EL4 cells.	Tetradecanoylphorbol Acetate	114-139	interleukin 17A	Mus musculus	49-54
25840633-6	2015	The effects of these compounds on phorbol 12-myristate 13-acetate (PMA)- induced MMP-9 gene and protein expression in airway epithelial cells (NCI-H292) were also investigated.	Tetradecanoylphorbol Acetate	34-65	matrix metallopeptidase 9	Homo sapiens	81-86
25840633-6	2015	The effects of these compounds on phorbol 12-myristate 13-acetate (PMA)- induced MMP-9 gene and protein expression in airway epithelial cells (NCI-H292) were also investigated.	Tetradecanoylphorbol Acetate	67-70	matrix metallopeptidase 9	Homo sapiens	81-86
25840633-13	2015	Furthermore, crude Phlai extracts (100 mg/ml) and compound D, at concentrations of 50 and 100 mg/ml, attenuated the PMA-induced MMP-9 gene and expression in NCI-H292 cells.	Tetradecanoylphorbol Acetate	116-119	matrix metallopeptidase 9	Homo sapiens	128-133
25447204-5	2015	A novel FFAT (two phenylalanines in an acidic tract)-like motif was identified in ORP3; only disruption of both the FFAT-like and canonical FFAT motif abolished the phorbol-12-myristate-13-acetate (PMA) stimulated interaction of ORP3-P with VAPA.	Tetradecanoylphorbol Acetate	198-201	oxysterol binding protein like 3	Homo sapiens	229-235
25698902-4	2015	Furthermore, the results of gelatin zymography and reverse transcriptase polymerase chain reaction (RT-PCR) assays showed that galangin reduced the TPA-induced enzyme activity of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in HepG2 cells; moreover, the messenger RNA level was downregulated.	Tetradecanoylphorbol Acetate	148-151	matrix metallopeptidase 9	Homo sapiens	218-244
25698902-4	2015	Furthermore, the results of gelatin zymography and reverse transcriptase polymerase chain reaction (RT-PCR) assays showed that galangin reduced the TPA-induced enzyme activity of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in HepG2 cells; moreover, the messenger RNA level was downregulated.	Tetradecanoylphorbol Acetate	148-151	matrix metallopeptidase 9	Homo sapiens	246-251
25698902-5	2015	We also observed through a Western blotting assay that galangin strongly inhibited the TPA-induced protein expressions of protein kinase Calpha (PKCalpha), protein kinase Cdelta (PKCdelta), phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2), the phospho-inhibitor of kappaBalpha (phospho-IkappaBalpha), c-Fos, c-Jun, and nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	87-90	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	318-323
25698902-5	2015	We also observed through a Western blotting assay that galangin strongly inhibited the TPA-induced protein expressions of protein kinase Calpha (PKCalpha), protein kinase Cdelta (PKCdelta), phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2), the phospho-inhibitor of kappaBalpha (phospho-IkappaBalpha), c-Fos, c-Jun, and nuclear factor kappa B (NF-kappaB).	Tetradecanoylphorbol Acetate	87-90	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	325-330
25486458-5	2015	Under steady state conditions, DPP9 was not seen at the plasma membrane, but upon stimulation with either phorbol 12-myristate 13-acetate or epidermal growth factor, some DPP9 re-distributed towards the ruffling membrane.	Tetradecanoylphorbol Acetate	106-137	dipeptidyl peptidase 9	Homo sapiens	31-35
25486458-5	2015	Under steady state conditions, DPP9 was not seen at the plasma membrane, but upon stimulation with either phorbol 12-myristate 13-acetate or epidermal growth factor, some DPP9 re-distributed towards the ruffling membrane.	Tetradecanoylphorbol Acetate	106-137	dipeptidyl peptidase 9	Homo sapiens	171-175
25533502-0	2015	Butein suppresses ICAM-1 expression through the inhibition of IkappaBalpha and c-Jun phosphorylation in TNF-alpha- and PMA-treated HUVECs.	Tetradecanoylphorbol Acetate	119-122	intercellular adhesion molecule 1	Homo sapiens	18-24
25533502-0	2015	Butein suppresses ICAM-1 expression through the inhibition of IkappaBalpha and c-Jun phosphorylation in TNF-alpha- and PMA-treated HUVECs.	Tetradecanoylphorbol Acetate	119-122	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-84
25449925-9	2015	In primary human macrophages, acetylated chitosan enhanced IL-1ra release without inducing IL-1beta, and required PMA priming to elicit STAT-1 activation and IP-10 release.	Tetradecanoylphorbol Acetate	114-117	signal transducer and activator of transcription 1	Homo sapiens	136-142
25449925-9	2015	In primary human macrophages, acetylated chitosan enhanced IL-1ra release without inducing IL-1beta, and required PMA priming to elicit STAT-1 activation and IP-10 release.	Tetradecanoylphorbol Acetate	114-117	C-X-C motif chemokine ligand 10	Homo sapiens	158-163
25789788-6	2015	Importantly, Suv39h1 overexpression in mice confers resistance to a DMBA/TPA induced skin carcinogenesis protocol that is characterized by the accumulation of activating H-ras mutations.	Tetradecanoylphorbol Acetate	73-76	Harvey rat sarcoma virus oncogene	Mus musculus	170-175
26021525-8	2015	Treatment of HUVEC and EA.hy 926 cells with PKC-activating phorbol esters (phorbol-12-myristate-13-acetate, PMA or phorbol-12,13-dibutyrate) resulted in a downregulation of BDNF expression, whereas the inactive 4alpha-phorbol-12,13-didecanoate was without effect.	Tetradecanoylphorbol Acetate	75-106	brain derived neurotrophic factor	Homo sapiens	173-177
26021525-10	2015	BDNF downregulation by PMA could be prevented by PKC inhibitors Go 6983 and rottlerin, but not by Go 6976.	Tetradecanoylphorbol Acetate	23-26	brain derived neurotrophic factor	Homo sapiens	0-4
26021525-11	2015	Thus, a Go 6983/rottlerin-sensitive PKC isoform is likely to be responsible for PMA-induced BDNF downregulation.	Tetradecanoylphorbol Acetate	80-83	brain derived neurotrophic factor	Homo sapiens	92-96
25489104-3	2014	Here we report that mice lacking DUSP5 show a greatly increased sensitivity to mutant Harvey-Ras (HRas(Q61L))-driven papilloma formation in the 7,12-Dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA) model of skin carcinogenesis.	Tetradecanoylphorbol Acetate	218-221	Harvey rat sarcoma virus oncogene	Mus musculus	86-96
25520561-8	2014	Furthermore, recombinant cavin-3 significantly prevented PMA-mediated dephosphorylation of AKT, a crucial regulator in MMP-9 transcription.	Tetradecanoylphorbol Acetate	57-60	matrix metallopeptidase 9	Homo sapiens	119-124
25449852-5	2014	Circulating Th1, Th2 and Th17 effector cells were identified by intracellular staining for IFN-gamma, IL-4 and IL-17, respectively, upon in vitro stimulation with PMA and calcium ionophore.	Tetradecanoylphorbol Acetate	163-166	negative elongation factor complex member C/D	Homo sapiens	12-15
25449852-5	2014	Circulating Th1, Th2 and Th17 effector cells were identified by intracellular staining for IFN-gamma, IL-4 and IL-17, respectively, upon in vitro stimulation with PMA and calcium ionophore.	Tetradecanoylphorbol Acetate	163-166	interleukin 17A	Homo sapiens	111-116
25339677-7	2014	We found that fMLF- and PMA-induced Rac activation were almost completely lost in mouse neutrophils lacking both DOCK2 and DOCK5.	Tetradecanoylphorbol Acetate	24-27	dedicator of cytokinesis 5	Mus musculus	123-128
25310083-1	2014	In the present study, in order to clarify the preventive mechanism of N-acetyl-L-cysteine (NAC) on arsenite-induced apoptosis in U937 cells, which lack functional p53, the cytotoxicity among U937 cells [monocytes and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated macrophages] receiving NAC treatment at different times post arsenite treatment was examined.	Tetradecanoylphorbol Acetate	217-253	X-linked Kx blood group	Homo sapiens	91-94
25310083-1	2014	In the present study, in order to clarify the preventive mechanism of N-acetyl-L-cysteine (NAC) on arsenite-induced apoptosis in U937 cells, which lack functional p53, the cytotoxicity among U937 cells [monocytes and 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated macrophages] receiving NAC treatment at different times post arsenite treatment was examined.	Tetradecanoylphorbol Acetate	255-258	X-linked Kx blood group	Homo sapiens	91-94
24240680-12	2014	Treatment with SCH66336 also induced near-complete regression of papillomas of TPA-treated Hras(G12V) knock-in mice.	Tetradecanoylphorbol Acetate	79-82	Harvey rat sarcoma virus oncogene	Mus musculus	91-95
25281873-6	2014	Significantly, we have found that activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) in LNCaP prostate cancer cells down-regulates the expression of NF-YA and PRMT5 at the transcription level in a c-Fos-dependent manner.	Tetradecanoylphorbol Acetate	74-105	nuclear transcription factor Y subunit alpha	Homo sapiens	176-181
25281873-6	2014	Significantly, we have found that activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) in LNCaP prostate cancer cells down-regulates the expression of NF-YA and PRMT5 at the transcription level in a c-Fos-dependent manner.	Tetradecanoylphorbol Acetate	74-105	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	224-229
25281873-6	2014	Significantly, we have found that activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) in LNCaP prostate cancer cells down-regulates the expression of NF-YA and PRMT5 at the transcription level in a c-Fos-dependent manner.	Tetradecanoylphorbol Acetate	107-110	nuclear transcription factor Y subunit alpha	Homo sapiens	176-181
25281873-6	2014	Significantly, we have found that activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) in LNCaP prostate cancer cells down-regulates the expression of NF-YA and PRMT5 at the transcription level in a c-Fos-dependent manner.	Tetradecanoylphorbol Acetate	107-110	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	224-229
24662765-0	2014	DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice.	Tetradecanoylphorbol Acetate	5-8	patched 1	Mus musculus	92-96
25113080-3	2014	We performed a meta-analysis and metaregression of the published literature to determine the best definition of mild strokes and if intravenously administered tissue plasminogen activator (IV-tPA) is beneficial.	Tetradecanoylphorbol Acetate	192-195	chromosome 20 open reading frame 181	Homo sapiens	159-187
25123184-6	2014	EGCG treatment significantly decreased mRNA and protein expression levels of MMP-9 in the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) and tumor necrosis factor alpha (TNF-alpha) in human retinal pigment epithelial cells (HRPECs).	Tetradecanoylphorbol Acetate	102-138	matrix metallopeptidase 9	Homo sapiens	77-82
25123184-6	2014	EGCG treatment significantly decreased mRNA and protein expression levels of MMP-9 in the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) and tumor necrosis factor alpha (TNF-alpha) in human retinal pigment epithelial cells (HRPECs).	Tetradecanoylphorbol Acetate	140-143	matrix metallopeptidase 9	Homo sapiens	77-82
24037529-5	2014	In contrast, TPA-promoted (that is, c-fos-activated) bi-genic HK1.ras-Delta5PTEN(flx) cohorts lost p53/p21 expression during early papillomatogenesis and rapidly produced poorly differentiated carcinomas (pdSCCs) with high BrdU-labelling and elevated cyclin D1/E2 expression levels, indicative of a progression mechanism driven by failures in cell-cycle control.	Tetradecanoylphorbol Acetate	13-16	hexokinase 1	Mus musculus	62-65
24037529-5	2014	In contrast, TPA-promoted (that is, c-fos-activated) bi-genic HK1.ras-Delta5PTEN(flx) cohorts lost p53/p21 expression during early papillomatogenesis and rapidly produced poorly differentiated carcinomas (pdSCCs) with high BrdU-labelling and elevated cyclin D1/E2 expression levels, indicative of a progression mechanism driven by failures in cell-cycle control.	Tetradecanoylphorbol Acetate	13-16	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	103-106
24037529-5	2014	In contrast, TPA-promoted (that is, c-fos-activated) bi-genic HK1.ras-Delta5PTEN(flx) cohorts lost p53/p21 expression during early papillomatogenesis and rapidly produced poorly differentiated carcinomas (pdSCCs) with high BrdU-labelling and elevated cyclin D1/E2 expression levels, indicative of a progression mechanism driven by failures in cell-cycle control.	Tetradecanoylphorbol Acetate	13-16	cyclin D1	Mus musculus	251-260
25161767-9	2014	In cultured cells, Insl6 inhibits Jurkat cell proliferation and activation in response to phytohemagglutinin/phorbol 12-myristate 13-acetate stimulation.	Tetradecanoylphorbol Acetate	109-140	insulin like 6	Homo sapiens	19-24
24946851-9	2014	A dose-dependent suppression in TPA-mediated TNF-alpha, IL-6, IFN-gamma, IL-17 and PGE2 levels which was associated with a decrease in infiltration of inflammatory cells was also observed with the treatment.	Tetradecanoylphorbol Acetate	32-35	interleukin 17A	Mus musculus	73-78
24867464-10	2014	On gelatinase zymography, all three cell lines showed bands corresponding to MMP-2 and LN-18 and T-98G showed PMA (100 ng/ml)-induced MMP-9.	Tetradecanoylphorbol Acetate	110-113	matrix metallopeptidase 9	Homo sapiens	134-139
25143809-0	2014	The Heterochromatin-1 Phosphorylation Contributes to TPA-Induced AP-1 Expression.	Tetradecanoylphorbol Acetate	53-56	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-69
25143809-4	2014	In the present study, we show that heterochromatin 1 gamma (HP1gamma) plays a negative role in TPA-induced c-Jun and c-Fos expression.	Tetradecanoylphorbol Acetate	95-98	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-112
25143809-4	2014	In the present study, we show that heterochromatin 1 gamma (HP1gamma) plays a negative role in TPA-induced c-Jun and c-Fos expression.	Tetradecanoylphorbol Acetate	95-98	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	117-122
24961897-3	2014	The results demonstrated that the planarization of TPA donor and the extended conjugation of pi-linker in sensitizers LC2 and LC3 could result in a red shift of absorption and a reduction in exciton binding energy, which is beneficial to enhance the matching degree of absorption of sensitizers with solar photon-flux spectrum and to improve the incident photon-to-current conversion efficiency, both contributing to the significant increase of photocurrent density as compared to reference dye LC1.	Tetradecanoylphorbol Acetate	51-54	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	126-129
24760882-7	2014	Lastly, Jurkat T cells latently infected with HIV (JLat cells) were more responsive to phorbol 12-myristate 13-acetate (PMA) reactivation in the absence of CYLD, indicating that CYLD activity could play a role in HIV reactivation from latency.	Tetradecanoylphorbol Acetate	87-118	CYLD lysine 63 deubiquitinase	Homo sapiens	178-182
24840330-13	2014	Taken together, our findings reveal that Slit2 promotes DMBA/TPA-induced skin tumorigenesis by increasing cell proliferation, microvessel density, and invasive behavior of cutaneous squamous cell carcinoma, along with loss of basement membrane, by upregulation of MMP2 expression.	Tetradecanoylphorbol Acetate	61-64	matrix metallopeptidase 2	Mus musculus	264-268
24985180-9	2014	Cells treated with both TPA and As2O3 expressed more CD11b antigens compared with the cells exposed to As2O3 alone.	Tetradecanoylphorbol Acetate	24-27	integrin subunit alpha M	Homo sapiens	53-58
24286317-5	2014	Furthermore, Bis knockdown notably decreased TPA-induced matrix metalloproteinase-9 (MMP-9) activity and mRNA expression, as measured by zymography and quantitative real time PCR, respectively.	Tetradecanoylphorbol Acetate	45-48	matrix metallopeptidase 9	Homo sapiens	57-83
24286317-5	2014	Furthermore, Bis knockdown notably decreased TPA-induced matrix metalloproteinase-9 (MMP-9) activity and mRNA expression, as measured by zymography and quantitative real time PCR, respectively.	Tetradecanoylphorbol Acetate	45-48	matrix metallopeptidase 9	Homo sapiens	85-90
24345425-5	2014	While a profound reduction of specific BDNF-related miRNAs (let7d, miR124 and miR132) may contribute to explaining the increased proBDNF levels, the up-regulation of the extracellular proteases tPA is indicative of increased processing leading to higher levels of released mBDNF.	Tetradecanoylphorbol Acetate	194-197	brain-derived neurotrophic factor	Rattus norvegicus	39-43
24515436-5	2014	Ankrd1 deletion enhanced both basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP13 promoter activity; conversely, Ankrd1 overexpression in control cells decreased PMA-induced MMP13 promoter activity.	Tetradecanoylphorbol Acetate	40-71	ankyrin repeat domain 1 (cardiac muscle)	Mus musculus	0-6
24515436-5	2014	Ankrd1 deletion enhanced both basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP13 promoter activity; conversely, Ankrd1 overexpression in control cells decreased PMA-induced MMP13 promoter activity.	Tetradecanoylphorbol Acetate	73-76	ankyrin repeat domain 1 (cardiac muscle)	Mus musculus	0-6
24515436-5	2014	Ankrd1 deletion enhanced both basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP13 promoter activity; conversely, Ankrd1 overexpression in control cells decreased PMA-induced MMP13 promoter activity.	Tetradecanoylphorbol Acetate	172-175	ankyrin repeat domain 1 (cardiac muscle)	Mus musculus	0-6
24515436-5	2014	Ankrd1 deletion enhanced both basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP13 promoter activity; conversely, Ankrd1 overexpression in control cells decreased PMA-induced MMP13 promoter activity.	Tetradecanoylphorbol Acetate	172-175	ankyrin repeat domain 1 (cardiac muscle)	Mus musculus	123-129
24519937-8	2014	Overexpressing PKCdelta followed by incubation with phorbol 12-myristate 13-acetate resulted in an increase in p65 Ser-536 phosphorylation and enhanced DNA binding affinity without affecting IkappaB degradation or p65 nuclear translocation.	Tetradecanoylphorbol Acetate	52-83	protein kinase C, delta	Mus musculus	15-23
23913269-5	2014	The aim of this study was to characterize the interactions between TG2 and sPLA2 in LPS-stimulated THP-1 cells, which were treated with TPA to induce early differentiated macrophage-type model.	Tetradecanoylphorbol Acetate	136-139	phospholipase A2 group IIA	Homo sapiens	75-80
24378964-7	2014	Parallel sets of cultures were treated with PMA (100 ng/ml) for induction of MMP-9.	Tetradecanoylphorbol Acetate	44-47	matrix metallopeptidase 9	Homo sapiens	77-82
24252747-9	2014	Coordinate up-regulation of Nnat and involucrin, but not cytokeratin1, was demonstrated in cultured keratinocytes under differentiation stimuli such as extracellular calcium elevation, exposure to phorbol myristate acetate, and increased cell density.	Tetradecanoylphorbol Acetate	197-222	neuronatin	Homo sapiens	28-32
24134140-6	2014	This conformational change was associated with faster phorbol 12-myristate 13-acetate-induced translocation and accumulation of fully phosphorylated PKCgamma in the insoluble fraction, which could be rescued by coexpressing PDK1 kinase that normally triggers PKCgamma autophosphorylation.	Tetradecanoylphorbol Acetate	54-85	pyruvate dehydrogenase kinase 1	Homo sapiens	224-228
24456812-8	2014	We further show that TPA specifically activates the shedding of alphaM/beta2 integrin (Mac-1), which was not shed upon LPS-stimulation of macrophages.	Tetradecanoylphorbol Acetate	21-24	hemoglobin, beta adult minor chain	Mus musculus	71-76
23396363-1	2014	The inducible proto-oncogenic (c-Fos:c-Jun)/AP-1 transcription complex binds 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive elements (TRE) in its target genes.	Tetradecanoylphorbol Acetate	77-113	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-36
23396363-1	2014	The inducible proto-oncogenic (c-Fos:c-Jun)/AP-1 transcription complex binds 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive elements (TRE) in its target genes.	Tetradecanoylphorbol Acetate	77-113	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-42
23396363-1	2014	The inducible proto-oncogenic (c-Fos:c-Jun)/AP-1 transcription complex binds 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive elements (TRE) in its target genes.	Tetradecanoylphorbol Acetate	115-118	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-36
23396363-1	2014	The inducible proto-oncogenic (c-Fos:c-Jun)/AP-1 transcription complex binds 12-O-tetradecanoylphorbol 13-acetate (TPA)-responsive elements (TRE) in its target genes.	Tetradecanoylphorbol Acetate	115-118	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-42
23396363-5	2014	Instead, thanks to the generation of an antibody specific for SUMO-modified c-Fos, we provide here direct evidence that SUMOylated c-Fos is present on a stably integrated reporter TPA-inducible promoter at the onset of transcriptional activation and colocalizes with RNA polymerase II within chromatin.	Tetradecanoylphorbol Acetate	180-183	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-81
23396363-5	2014	Instead, thanks to the generation of an antibody specific for SUMO-modified c-Fos, we provide here direct evidence that SUMOylated c-Fos is present on a stably integrated reporter TPA-inducible promoter at the onset of transcriptional activation and colocalizes with RNA polymerase II within chromatin.	Tetradecanoylphorbol Acetate	180-183	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-136
23396363-8	2014	Finally, activation of GADD153, an AP-1 target gene, is also associated with a rapid increase in SUMOylation at the level of its TRE and c-Fos SUMOylation dampens its induction by TPA.	Tetradecanoylphorbol Acetate	180-183	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-142
24286866-4	2014	TIM-1 and TIM-4 lacking the intracellular domain were efficiently cleaved after ionomycin- and PMA-treatment, indicating that the intracellular domain was not necessary for ectodomain shedding.	Tetradecanoylphorbol Acetate	95-98	hepatitis A virus cellular receptor 1	Homo sapiens	0-5
24753817-11	2014	Overall, these results suggested that TPA induced K8 phosphorylation and reorganization via Tgase-2 expression in PANC-1 cells.	Tetradecanoylphorbol Acetate	38-41	keratin 8	Homo sapiens	50-52
24258363-4	2014	In addition, the MSE inhibitory effect on upstream of NFkappaB was found to involve the transcriptional effects of MAPK signaling as indicated by strong suppression on TPA-induced activation of extracellular signal regulate kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt.	Tetradecanoylphorbol Acetate	168-171	mitogen-activated protein kinase 8	Mus musculus	286-318
24297175-8	2014	Arginine vasopressin (100 and 500 pm) and the PKC activator phorbol 12-myristate 13-acetate (1 nm) each inhibited human (h) Kv7.5 and hKv7.4/7.5, but not hKv7.4 channels expressed in A7r5 cells.	Tetradecanoylphorbol Acetate	60-91	protein kinase C, alpha	Rattus norvegicus	46-49
24433534-4	2014	METHODS: In this study, the possible mechanisms underlying Gen-mediated reduction of 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced cell invasion and inhibition of secreted and cytosolic MMP-9 production in human hepatoma cells (HepG2, Huh-7, and HA22T) and murine embryonic liver cells (BNL CL2) were investigated.	Tetradecanoylphorbol Acetate	85-121	MIR7-3 host gene	Homo sapiens	240-245
24433534-4	2014	METHODS: In this study, the possible mechanisms underlying Gen-mediated reduction of 12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced cell invasion and inhibition of secreted and cytosolic MMP-9 production in human hepatoma cells (HepG2, Huh-7, and HA22T) and murine embryonic liver cells (BNL CL2) were investigated.	Tetradecanoylphorbol Acetate	123-126	MIR7-3 host gene	Homo sapiens	240-245
24404184-7	2014	Using neutrophil-like differentiated HL60 cells, we show here that Rab27a plays an essential role in both phorbol myristate acetate (PMA)- and Candida albicans-induced NET formation by regulating ROS production.	Tetradecanoylphorbol Acetate	106-131	RAB27A, member RAS oncogene family	Homo sapiens	67-73
24404184-7	2014	Using neutrophil-like differentiated HL60 cells, we show here that Rab27a plays an essential role in both phorbol myristate acetate (PMA)- and Candida albicans-induced NET formation by regulating ROS production.	Tetradecanoylphorbol Acetate	133-136	RAB27A, member RAS oncogene family	Homo sapiens	67-73
24173318-7	2014	Luciferase assays showed that HF decreases TPA-induced MMP-9 promoter binding activities of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	43-46	matrix metallopeptidase 9	Homo sapiens	55-60
24173318-7	2014	Luciferase assays showed that HF decreases TPA-induced MMP-9 promoter binding activities of NF-kappaB and AP-1.	Tetradecanoylphorbol Acetate	43-46	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-110
24465258-2	2014	A large administrative database was evaluated to determine the outcomes of mechanical thrombectomy and intravenous tissue plasminogen activator (IV-tPA) for the treatment of posterior-circulation (vertebrobasilar) strokes.	Tetradecanoylphorbol Acetate	148-151	chromosome 20 open reading frame 181	Homo sapiens	115-143
24174064-5	2014	Matrix metalloproteinase-9 (MMP-9) activity in the resting and PMA-stimulated state in HT1080 cells was dose-dependently decreased by KIOM-C treatment via suppression of NF-kappaB activation.	Tetradecanoylphorbol Acetate	63-66	matrix metallopeptidase 9	Homo sapiens	0-26
24174064-5	2014	Matrix metalloproteinase-9 (MMP-9) activity in the resting and PMA-stimulated state in HT1080 cells was dose-dependently decreased by KIOM-C treatment via suppression of NF-kappaB activation.	Tetradecanoylphorbol Acetate	63-66	matrix metallopeptidase 9	Homo sapiens	28-33
24246425-6	2014	Furthermore, downregulation of FosB or cJun suppressed the CRF gene expression induced by forskolin, PMA, or A23187.	Tetradecanoylphorbol Acetate	101-104	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-35
24094605-8	2014	CONCLUSION: The present data evidence that CPB activity generates fine-mesh fibrin which is more difficult to lyse by tPA, but conversely, CPB and plasmin together can stimulate fibrinolysis, possibly by enhancing plasmin diffusion.	Tetradecanoylphorbol Acetate	118-121	carboxypeptidase B1	Homo sapiens	43-46
24386331-3	2013	We report that PMA strongly induced c-Fos expression, but tumor necrosis factor (TNF)-alpha did not.	Tetradecanoylphorbol Acetate	15-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	36-41
24308937-1	2013	BACKGROUND: The early identification of patients who are unlikely to respond to intravenous recombinant tissue plasminogen activator (IV-tPA) could help select candidates for additional intra-arterial therapy or add-on antithrombotic drugs during the acute stage of stroke.	Tetradecanoylphorbol Acetate	137-140	chromosome 20 open reading frame 181	Homo sapiens	104-132
24126491-7	2013	RT-PCR analysis demonstrated that PMA upregulated the expression of intercellular adhesion molecule-1 (ICAM-1) in HL-60 cells, and that anti-ICAM-1 monoclonal antibody not only abrogated PMA-induced aggregation and adhesion of the cells but also restored its sensitivity to Vitex.	Tetradecanoylphorbol Acetate	34-37	intercellular adhesion molecule 1	Homo sapiens	68-101
24126491-7	2013	RT-PCR analysis demonstrated that PMA upregulated the expression of intercellular adhesion molecule-1 (ICAM-1) in HL-60 cells, and that anti-ICAM-1 monoclonal antibody not only abrogated PMA-induced aggregation and adhesion of the cells but also restored its sensitivity to Vitex.	Tetradecanoylphorbol Acetate	34-37	intercellular adhesion molecule 1	Homo sapiens	103-109
24126491-7	2013	RT-PCR analysis demonstrated that PMA upregulated the expression of intercellular adhesion molecule-1 (ICAM-1) in HL-60 cells, and that anti-ICAM-1 monoclonal antibody not only abrogated PMA-induced aggregation and adhesion of the cells but also restored its sensitivity to Vitex.	Tetradecanoylphorbol Acetate	34-37	intercellular adhesion molecule 1	Homo sapiens	141-147
24126491-7	2013	RT-PCR analysis demonstrated that PMA upregulated the expression of intercellular adhesion molecule-1 (ICAM-1) in HL-60 cells, and that anti-ICAM-1 monoclonal antibody not only abrogated PMA-induced aggregation and adhesion of the cells but also restored its sensitivity to Vitex.	Tetradecanoylphorbol Acetate	187-190	intercellular adhesion molecule 1	Homo sapiens	141-147
24121505-4	2013	PMA-induced shedding of Tim-3 was abrogated by deletion of amino acids Glu(181)-Asp(190) of the stalk region and Tim-3 lacking the intracellular domain was not efficiently cleaved after PMA stimulation.	Tetradecanoylphorbol Acetate	0-3	hepatitis A virus cellular receptor 2	Homo sapiens	24-29
24121505-4	2013	PMA-induced shedding of Tim-3 was abrogated by deletion of amino acids Glu(181)-Asp(190) of the stalk region and Tim-3 lacking the intracellular domain was not efficiently cleaved after PMA stimulation.	Tetradecanoylphorbol Acetate	0-3	hepatitis A virus cellular receptor 2	Homo sapiens	113-118
23983193-5	2013	The different Toc-isoforms suppressed inflammatory response in interferon (IFN) gamma/phorbol myristate acetate (PMA)-induced Caco-2 adult-derived intestinal epithelial cells, but exacerbated both IL8 and PGE2 secretion in fetal-derived FHs 74 Int intestinal epithelial cells.	Tetradecanoylphorbol Acetate	86-111	rhomboid 5 homolog 2	Homo sapiens	14-17
23983193-5	2013	The different Toc-isoforms suppressed inflammatory response in interferon (IFN) gamma/phorbol myristate acetate (PMA)-induced Caco-2 adult-derived intestinal epithelial cells, but exacerbated both IL8 and PGE2 secretion in fetal-derived FHs 74 Int intestinal epithelial cells.	Tetradecanoylphorbol Acetate	113-116	rhomboid 5 homolog 2	Homo sapiens	14-17
24008507-7	2013	Similar to the inhibitory effects shown in MDA-MB-231 cells, we observed that DSW treatment resulted in the inhibition of TPA-induced migration and MMP-9 activity with a concomitant decrease in mRNA levels of MMP-9, TGF-beta, Wnt5a and Wnt3a.	Tetradecanoylphorbol Acetate	122-125	matrix metallopeptidase 9	Homo sapiens	148-153
23900236-10	2013	U-2OS osteosarcoma cells showed strong bands corresponding to inactive MMP-2 and MMP-9 and faint bands corresponding to active MMP-2 and MMP-9 dimer; PMA treatment enhanced MMP-9 and MMP-9 dimer activity.	Tetradecanoylphorbol Acetate	150-153	matrix metallopeptidase 9	Homo sapiens	137-142
23900236-9	2013	On gelatinase zymography, osteosarcoma MNNG-HOS showed a band corresponding to MMP-2 and induction of MMP-9 with PMA (100 ng/ml) treatment.	Tetradecanoylphorbol Acetate	113-116	matrix metallopeptidase 9	Homo sapiens	102-107
23900236-10	2013	U-2OS osteosarcoma cells showed strong bands corresponding to inactive MMP-2 and MMP-9 and faint bands corresponding to active MMP-2 and MMP-9 dimer; PMA treatment enhanced MMP-9 and MMP-9 dimer activity.	Tetradecanoylphorbol Acetate	150-153	matrix metallopeptidase 9	Homo sapiens	81-86
23900236-10	2013	U-2OS osteosarcoma cells showed strong bands corresponding to inactive MMP-2 and MMP-9 and faint bands corresponding to active MMP-2 and MMP-9 dimer; PMA treatment enhanced MMP-9 and MMP-9 dimer activity.	Tetradecanoylphorbol Acetate	150-153	matrix metallopeptidase 9	Homo sapiens	137-142
23900236-10	2013	U-2OS osteosarcoma cells showed strong bands corresponding to inactive MMP-2 and MMP-9 and faint bands corresponding to active MMP-2 and MMP-9 dimer; PMA treatment enhanced MMP-9 and MMP-9 dimer activity.	Tetradecanoylphorbol Acetate	150-153	matrix metallopeptidase 9	Homo sapiens	137-142
23900236-11	2013	Rhabdomyosarcoma showed MMP-2 and faint MMP-9 bands; PMA treatment enhanced MMP-9 expression.	Tetradecanoylphorbol Acetate	53-56	matrix metallopeptidase 9	Homo sapiens	76-81
23758794-4	2013	Compound IVn was also found to inhibit PMA-induced MMP-9 expression in MDA-MB-231 cells at sublethal concentrations.	Tetradecanoylphorbol Acetate	39-42	matrix metallopeptidase 9	Homo sapiens	51-56
24089228-13	2013	It was noteworthy that the ERK activator (phorbol 12-myristate 13-acetate [PMA]) treatment increased the MMP-9/VEGF levels after propofol treatment, and led to significant increase of proliferation, invasion and angiogenesis.	Tetradecanoylphorbol Acetate	42-73	matrix metallopeptidase 9	Homo sapiens	105-110
24089228-13	2013	It was noteworthy that the ERK activator (phorbol 12-myristate 13-acetate [PMA]) treatment increased the MMP-9/VEGF levels after propofol treatment, and led to significant increase of proliferation, invasion and angiogenesis.	Tetradecanoylphorbol Acetate	75-78	matrix metallopeptidase 9	Homo sapiens	105-110
23856463-1	2013	The cell surface glycoprotein CD44 enhances phorbol-12-myristate 13-acetate (TPA)-induced expression of p21WAF1 by stabilizing its mRNA and enhancing the protein"s half-life in several cell lines.	Tetradecanoylphorbol Acetate	44-75	CD44 molecule (Indian blood group)	Homo sapiens	30-34
23856463-1	2013	The cell surface glycoprotein CD44 enhances phorbol-12-myristate 13-acetate (TPA)-induced expression of p21WAF1 by stabilizing its mRNA and enhancing the protein"s half-life in several cell lines.	Tetradecanoylphorbol Acetate	77-80	CD44 molecule (Indian blood group)	Homo sapiens	30-34
23434434-9	2013	Physostigmine, in the concentration range tested, suppressed the expression of CD11b following stimulation with PMA not significantly (human PMN: control: 63.1+-10.7 vs. 97 muM physostigmine: 49.9+-12.8 MESF, p=n.s.).	Tetradecanoylphorbol Acetate	112-115	integrin subunit alpha M	Homo sapiens	79-84
23786520-6	2013	Moreover, pretreatment with 1 suppressed TPA-triggered induction of NOX2 and membrane translocation of p47(phox).	Tetradecanoylphorbol Acetate	41-44	cytochrome b-245 beta chain	Homo sapiens	68-72
23786520-7	2013	Overall, it is revealed that 1 suppresses TPA-triggered induction of CD families by the prevention of NOX2 activation.	Tetradecanoylphorbol Acetate	42-45	cytochrome b-245 beta chain	Homo sapiens	102-106
23055378-4	2013	Skin tumours obtained in the DMBA/TPA group exhibited enhanced expression of proliferating cell nuclear antigen (PCNA, index of proliferation), p21 and cyclin D1, with no alterations in p53 expression in comparison to the control group.	Tetradecanoylphorbol Acetate	34-37	proliferating cell nuclear antigen	Mus musculus	77-111
23055378-4	2013	Skin tumours obtained in the DMBA/TPA group exhibited enhanced expression of proliferating cell nuclear antigen (PCNA, index of proliferation), p21 and cyclin D1, with no alterations in p53 expression in comparison to the control group.	Tetradecanoylphorbol Acetate	34-37	proliferating cell nuclear antigen	Mus musculus	113-117
23055378-4	2013	Skin tumours obtained in the DMBA/TPA group exhibited enhanced expression of proliferating cell nuclear antigen (PCNA, index of proliferation), p21 and cyclin D1, with no alterations in p53 expression in comparison to the control group.	Tetradecanoylphorbol Acetate	34-37	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	144-147
23055378-4	2013	Skin tumours obtained in the DMBA/TPA group exhibited enhanced expression of proliferating cell nuclear antigen (PCNA, index of proliferation), p21 and cyclin D1, with no alterations in p53 expression in comparison to the control group.	Tetradecanoylphorbol Acetate	34-37	cyclin D1	Mus musculus	152-161
23055378-5	2013	Tumours in AAILE + DMBA/TPA group exhibited low PCNA and cyclin D1 expression and enhanced expression of p53 and p21 in comparison to the DMBA/TPA group.	Tetradecanoylphorbol Acetate	24-27	proliferating cell nuclear antigen	Mus musculus	48-52
23055378-5	2013	Tumours in AAILE + DMBA/TPA group exhibited low PCNA and cyclin D1 expression and enhanced expression of p53 and p21 in comparison to the DMBA/TPA group.	Tetradecanoylphorbol Acetate	24-27	cyclin D1	Mus musculus	57-66
23055378-5	2013	Tumours in AAILE + DMBA/TPA group exhibited low PCNA and cyclin D1 expression and enhanced expression of p53 and p21 in comparison to the DMBA/TPA group.	Tetradecanoylphorbol Acetate	24-27	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	113-116
23661254-10	2013	On gelatinase zymography, fibrosarcoma, chondrosarcoma, liposarcoma and synovial sarcoma showed bands corresponding to MMP-2 and MMP-9 with enhancement of MMP-9 with PMA (100 ng/ml) treatment.	Tetradecanoylphorbol Acetate	166-169	matrix metallopeptidase 9	Homo sapiens	155-160
23661254-11	2013	Uterine leiomyosarcoma showed strong bands corresponding to inactive and active MMP-9 and a faint band corresponding to MMP-9 dimer induced with PMA treatment, but no MMP-2 band.	Tetradecanoylphorbol Acetate	145-148	matrix metallopeptidase 9	Homo sapiens	120-125
23228462-7	2013	Finally, we showed that, contrary to the PKC inhibitors, the PKC activator phorbol 12-myristate 13-acetate (PMA) enhanced risk-taking behavior and induced an antidepressant-like effect.	Tetradecanoylphorbol Acetate	75-106	protein kinase C, gamma	Rattus norvegicus	61-64
23228462-7	2013	Finally, we showed that, contrary to the PKC inhibitors, the PKC activator phorbol 12-myristate 13-acetate (PMA) enhanced risk-taking behavior and induced an antidepressant-like effect.	Tetradecanoylphorbol Acetate	108-111	protein kinase C, gamma	Rattus norvegicus	61-64
22351517-6	2013	TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-43
22351517-6	2013	TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-49
23528267-2	2013	Rat primary cultures of DRG neurons were stimulated with phorbol-12-myristate-13-acetate (PMA), a potent activator of protein kinase C (PKC), which resulted in the robust expression of both BDNF mRNA and protein.	Tetradecanoylphorbol Acetate	57-88	protein kinase C, gamma	Rattus norvegicus	118-134
23528267-2	2013	Rat primary cultures of DRG neurons were stimulated with phorbol-12-myristate-13-acetate (PMA), a potent activator of protein kinase C (PKC), which resulted in the robust expression of both BDNF mRNA and protein.	Tetradecanoylphorbol Acetate	57-88	protein kinase C, gamma	Rattus norvegicus	136-139
23528267-2	2013	Rat primary cultures of DRG neurons were stimulated with phorbol-12-myristate-13-acetate (PMA), a potent activator of protein kinase C (PKC), which resulted in the robust expression of both BDNF mRNA and protein.	Tetradecanoylphorbol Acetate	57-88	brain-derived neurotrophic factor	Rattus norvegicus	190-194
23288142-10	2013	HO-1 siRNA alleviated the inhibition by DHA of TPA-induced MMP-9 protein expression and enzyme activity in MCF-7 cells, and HO-1 knockdown reversed the DHA inhibition of cell migration.	Tetradecanoylphorbol Acetate	47-50	matrix metallopeptidase 9	Homo sapiens	59-64
23114726-0	2013	Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 breast adenocarcinoma cells invasion/migration by alpha-tomatine through activating PKCalpha/ERK/NF-kappaB-dependent MMP-2/MMP-9 expressions.	Tetradecanoylphorbol Acetate	15-51	matrix metallopeptidase 9	Homo sapiens	189-194
23945300-3	2013	The proportion of Th1 and Th17 cells in the PBMCs was detected with flow cytometry after stimulated by PMA and ionomycin.	Tetradecanoylphorbol Acetate	103-106	negative elongation factor complex member C/D	Homo sapiens	18-21
23671446-8	2013	RESULTS: Midazolam significantly down-regulated PMA-induced MMP-9 protein expression at concentrations of 5, 10 and 20 microM, the values were 1.95 +-0.09 (p &lt; 0.01), 1.71 +-0.12 (p &lt; 0.01) and 1.35 +-0.20 (p &lt; 0.001), respectively.	Tetradecanoylphorbol Acetate	48-51	matrix metallopeptidase 9	Homo sapiens	60-65
23528311-5	2013	The cells were also treated with PMA to induce MMP-9 expression.	Tetradecanoylphorbol Acetate	33-36	matrix metallopeptidase 9	Homo sapiens	47-52
23262392-9	2013	When preincubated oocytes with phorbol-12-myristate-13-acetate (PMA, a PKC activator) were exposed to caffeine, PMA-induced increase in EAAT3 activity was abolished.	Tetradecanoylphorbol Acetate	31-62	solute carrier family 1 member 1	Rattus norvegicus	136-141
23262392-9	2013	When preincubated oocytes with phorbol-12-myristate-13-acetate (PMA, a PKC activator) were exposed to caffeine, PMA-induced increase in EAAT3 activity was abolished.	Tetradecanoylphorbol Acetate	64-67	solute carrier family 1 member 1	Rattus norvegicus	136-141
23262392-9	2013	When preincubated oocytes with phorbol-12-myristate-13-acetate (PMA, a PKC activator) were exposed to caffeine, PMA-induced increase in EAAT3 activity was abolished.	Tetradecanoylphorbol Acetate	112-115	solute carrier family 1 member 1	Rattus norvegicus	136-141
23362866-9	2013	In the murine model, 11beta-HSD1 expression was decreased in TPA-treated hyperproliferative skin.	Tetradecanoylphorbol Acetate	61-64	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	21-32
22718316-9	2013	TPA-induced DSPC secretion and apoptosis were elevated in VEGF-deficient type II cells.	Tetradecanoylphorbol Acetate	0-3	vascular endothelial growth factor A	Mus musculus	58-62
24804016-6	2013	Gene expression results in HUVEC showed that cinnamon extract treatment inhibited TPA induction of protein kinase C, PKCalpha and PKCeta messenger RNA (mRNA) expression in a dose-dependent manner along with suppression of vascular endothelial growth factor receptor 1 (VEGFR1/Flt1) and vascular endothelial growth factor receptor 2 (VEGFR2/KDR/Flk1) mRNA expression.	Tetradecanoylphorbol Acetate	82-85	kinase insert domain receptor	Homo sapiens	333-339
23236172-2	2012	Using epidermis-specific Itga3 KO mice subjected to the 7,12-dimethylbenzanthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate two-stage skin carcinogenesis protocol, we demonstrate that efficient tumor development is critically dependent on the presence of alpha3beta1.	Tetradecanoylphorbol Acetate	91-127	integrin alpha 3	Mus musculus	25-30
23198878-0	2012	Murine CD4+CD25- cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo.	Tetradecanoylphorbol Acetate	47-50	CD4 antigen	Mus musculus	7-10
23198878-0	2012	Murine CD4+CD25- cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo.	Tetradecanoylphorbol Acetate	47-50	interleukin 2 receptor, alpha chain	Mus musculus	11-15
23198878-5	2012	METHODS: Using phorbol myristate acetate (PMA)/ionomycin and anti-CD3 activation of CD4+CD25- cells we generated in vitro functional CD4+CD25- iTreg (TregPMA) cells.	Tetradecanoylphorbol Acetate	15-40	CD4 antigen	Mus musculus	133-136
23198878-5	2012	METHODS: Using phorbol myristate acetate (PMA)/ionomycin and anti-CD3 activation of CD4+CD25- cells we generated in vitro functional CD4+CD25- iTreg (TregPMA) cells.	Tetradecanoylphorbol Acetate	15-40	interleukin 2 receptor, alpha chain	Mus musculus	137-141
23198878-5	2012	METHODS: Using phorbol myristate acetate (PMA)/ionomycin and anti-CD3 activation of CD4+CD25- cells we generated in vitro functional CD4+CD25- iTreg (TregPMA) cells.	Tetradecanoylphorbol Acetate	42-45	CD4 antigen	Mus musculus	133-136
23198878-5	2012	METHODS: Using phorbol myristate acetate (PMA)/ionomycin and anti-CD3 activation of CD4+CD25- cells we generated in vitro functional CD4+CD25- iTreg (TregPMA) cells.	Tetradecanoylphorbol Acetate	42-45	interleukin 2 receptor, alpha chain	Mus musculus	137-141
23123091-6	2012	Knocking down PTEN expression via siRNA inhibited TPA-induced Bax expression.	Tetradecanoylphorbol Acetate	50-53	BCL2-associated X protein	Mus musculus	62-65
22736020-9	2012	FOXP3+ mucosal CD4+ T cells from both IBD and control specimens were able to make IL-17A in vitro after phorbol myristate acetate (PMA) and ionomycin stimulation, but these cells did not preferentially express Deltaexon2.	Tetradecanoylphorbol Acetate	104-129	interleukin 17A	Homo sapiens	82-88
22736020-9	2012	FOXP3+ mucosal CD4+ T cells from both IBD and control specimens were able to make IL-17A in vitro after phorbol myristate acetate (PMA) and ionomycin stimulation, but these cells did not preferentially express Deltaexon2.	Tetradecanoylphorbol Acetate	131-134	interleukin 17A	Homo sapiens	82-88
22749933-9	2012	Knockdown of Romo1 in Hep3B and Huh-7 HCC cells reduced their invasive activity in response to stimulation with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	112-148	reactive oxygen species modulator 1	Homo sapiens	13-18
22871965-1	2012	Phorbol 12-myristate 13-acetate (PMA) increased 1,25(OH)(2)D(3)-induced human 25 hydroxyvitamin d-24 hydroxylase (hCYP24A1) gene expression and vitamin D receptor (VDR) binding to the hCYP24A1 promoter.	Tetradecanoylphorbol Acetate	0-31	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	114-122
22871965-1	2012	Phorbol 12-myristate 13-acetate (PMA) increased 1,25(OH)(2)D(3)-induced human 25 hydroxyvitamin d-24 hydroxylase (hCYP24A1) gene expression and vitamin D receptor (VDR) binding to the hCYP24A1 promoter.	Tetradecanoylphorbol Acetate	0-31	vitamin D receptor	Homo sapiens	144-162
22871965-1	2012	Phorbol 12-myristate 13-acetate (PMA) increased 1,25(OH)(2)D(3)-induced human 25 hydroxyvitamin d-24 hydroxylase (hCYP24A1) gene expression and vitamin D receptor (VDR) binding to the hCYP24A1 promoter.	Tetradecanoylphorbol Acetate	0-31	vitamin D receptor	Homo sapiens	164-167
22871965-1	2012	Phorbol 12-myristate 13-acetate (PMA) increased 1,25(OH)(2)D(3)-induced human 25 hydroxyvitamin d-24 hydroxylase (hCYP24A1) gene expression and vitamin D receptor (VDR) binding to the hCYP24A1 promoter.	Tetradecanoylphorbol Acetate	0-31	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	184-192
22871965-1	2012	Phorbol 12-myristate 13-acetate (PMA) increased 1,25(OH)(2)D(3)-induced human 25 hydroxyvitamin d-24 hydroxylase (hCYP24A1) gene expression and vitamin D receptor (VDR) binding to the hCYP24A1 promoter.	Tetradecanoylphorbol Acetate	33-36	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	114-122
22871965-1	2012	Phorbol 12-myristate 13-acetate (PMA) increased 1,25(OH)(2)D(3)-induced human 25 hydroxyvitamin d-24 hydroxylase (hCYP24A1) gene expression and vitamin D receptor (VDR) binding to the hCYP24A1 promoter.	Tetradecanoylphorbol Acetate	33-36	vitamin D receptor	Homo sapiens	144-162
22871965-1	2012	Phorbol 12-myristate 13-acetate (PMA) increased 1,25(OH)(2)D(3)-induced human 25 hydroxyvitamin d-24 hydroxylase (hCYP24A1) gene expression and vitamin D receptor (VDR) binding to the hCYP24A1 promoter.	Tetradecanoylphorbol Acetate	33-36	vitamin D receptor	Homo sapiens	164-167
22871965-1	2012	Phorbol 12-myristate 13-acetate (PMA) increased 1,25(OH)(2)D(3)-induced human 25 hydroxyvitamin d-24 hydroxylase (hCYP24A1) gene expression and vitamin D receptor (VDR) binding to the hCYP24A1 promoter.	Tetradecanoylphorbol Acetate	33-36	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	184-192
22977714-0	2012	Phorbol 12-Myristate 13-Acetate Induces MUC16 Expression via PKCdelta and p38 in Human Airway Epithelial Cells.	Tetradecanoylphorbol Acetate	0-31	mucin 16, cell surface associated	Homo sapiens	40-45
22977714-8	2012	SB203580 (p38 MAPK inhibitor) inhibited PMA-induced MUC16 expression, while U0126 (ERK1/2 inhibitor) did not.	Tetradecanoylphorbol Acetate	40-43	mucin 16, cell surface associated	Homo sapiens	52-57
22488409-2	2012	Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	79-110	matrix metallopeptidase 9	Homo sapiens	48-53
22488409-2	2012	Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	79-110	matrix metallopeptidase 9	Homo sapiens	125-130
22488409-2	2012	Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	79-110	matrix metallopeptidase 9	Homo sapiens	125-130
22488409-2	2012	Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	112-115	matrix metallopeptidase 9	Homo sapiens	48-53
22488409-2	2012	Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	112-115	matrix metallopeptidase 9	Homo sapiens	125-130
22488409-2	2012	Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	112-115	matrix metallopeptidase 9	Homo sapiens	125-130
22578382-9	2012	A constitutively active mutant of CaMKII activated a luciferase reporter plasmid under the control of MEF2, when cotransfected in T lymphocytes stimulated by Ionomycin and PMA, whereas its inhibitor KN-62 inhibited MEF2 binding in cell lysates of the same cells.	Tetradecanoylphorbol Acetate	172-175	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	34-40
22710295-6	2012	RESULTS: The results showed that ERP significantly decreased the ear thickness and MPO activity in mouse model of inflammation induced by TPA.	Tetradecanoylphorbol Acetate	138-141	myeloperoxidase	Mus musculus	83-86
22696685-3	2012	We show that treatment with a combination of phorbol 12-myristate 13-acetate (PMA) plus ionophore A23187 (Io), which induces NFAT activation, increased REDD1 mRNA and protein expression and inhibited mTOR signaling; pretreatment with the calcineurin inhibitor cyclosporin A (CsA), an antagonist of NFAT signaling, decreased REDD1 induction and mTOR inhibition.	Tetradecanoylphorbol Acetate	45-76	DNA damage inducible transcript 4	Homo sapiens	152-157
22696685-3	2012	We show that treatment with a combination of phorbol 12-myristate 13-acetate (PMA) plus ionophore A23187 (Io), which induces NFAT activation, increased REDD1 mRNA and protein expression and inhibited mTOR signaling; pretreatment with the calcineurin inhibitor cyclosporin A (CsA), an antagonist of NFAT signaling, decreased REDD1 induction and mTOR inhibition.	Tetradecanoylphorbol Acetate	45-76	DNA damage inducible transcript 4	Homo sapiens	324-329
22696685-3	2012	We show that treatment with a combination of phorbol 12-myristate 13-acetate (PMA) plus ionophore A23187 (Io), which induces NFAT activation, increased REDD1 mRNA and protein expression and inhibited mTOR signaling; pretreatment with the calcineurin inhibitor cyclosporin A (CsA), an antagonist of NFAT signaling, decreased REDD1 induction and mTOR inhibition.	Tetradecanoylphorbol Acetate	78-81	DNA damage inducible transcript 4	Homo sapiens	152-157
22696685-3	2012	We show that treatment with a combination of phorbol 12-myristate 13-acetate (PMA) plus ionophore A23187 (Io), which induces NFAT activation, increased REDD1 mRNA and protein expression and inhibited mTOR signaling; pretreatment with the calcineurin inhibitor cyclosporin A (CsA), an antagonist of NFAT signaling, decreased REDD1 induction and mTOR inhibition.	Tetradecanoylphorbol Acetate	78-81	DNA damage inducible transcript 4	Homo sapiens	324-329
22607136-1	2012	Previous work has demonstrated that phorbol ester (TPA)-induced adherence of human U937 myeloid leukemia cells can be blocked upon down-modulation of the beta2-integrin CD11b after stable transfection of U937 cells with a pMTH1 vector-containing the CD11b gene in antisense orientation (asCD11b-U937) [Otte et al., (2011)].	Tetradecanoylphorbol Acetate	51-54	integrin subunit alpha M	Homo sapiens	169-174
22607136-1	2012	Previous work has demonstrated that phorbol ester (TPA)-induced adherence of human U937 myeloid leukemia cells can be blocked upon down-modulation of the beta2-integrin CD11b after stable transfection of U937 cells with a pMTH1 vector-containing the CD11b gene in antisense orientation (asCD11b-U937) [Otte et al., (2011)].	Tetradecanoylphorbol Acetate	51-54	integrin subunit alpha M	Homo sapiens	250-255
22381172-0	2012	Berberine suppresses the TPA-induced MMP-1 and MMP-9 expressions through the inhibition of PKC-alpha in breast cancer cells.	Tetradecanoylphorbol Acetate	25-28	matrix metallopeptidase 9	Homo sapiens	47-52
22381172-9	2012	In contrast, TPA, which is a tumor promoter, significantly increased the levels of the MMP-1 and MMP-9 mRNA and protein expressions in the MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	13-16	matrix metallopeptidase 9	Homo sapiens	97-102
22381172-10	2012	We also observed that the TPA-induced MMP-1 and MMP-9 mRNA and protein expressions were prevented by BBR treatment.	Tetradecanoylphorbol Acetate	26-29	matrix metallopeptidase 9	Homo sapiens	48-53
22381172-11	2012	In addition, the TPA-induced MMP-1 and MMP-9 expressions were completely decreased by Go6983 and PKC-alpha siRNA, respectively.	Tetradecanoylphorbol Acetate	17-20	matrix metallopeptidase 9	Homo sapiens	39-44
22381172-13	2012	CONCLUSION: The TPA-induced PKC-alpha phosphorylation is suppressed and then the MMP-1 and MMP-9 expressions are also inhibited by berberine.	Tetradecanoylphorbol Acetate	16-19	matrix metallopeptidase 9	Homo sapiens	91-96
22484090-3	2012	Phorbol-12-myristate-13-acetate (PMA) treated THP-1 cells stimulated with rBm33 and subsequent incubation with GFP expressing Escherichia coli (E. coli) for 2 h enhanced the uptake of E. coli.	Tetradecanoylphorbol Acetate	0-31	RNA binding motif protein 33	Rattus norvegicus	74-79
22484090-3	2012	Phorbol-12-myristate-13-acetate (PMA) treated THP-1 cells stimulated with rBm33 and subsequent incubation with GFP expressing Escherichia coli (E. coli) for 2 h enhanced the uptake of E. coli.	Tetradecanoylphorbol Acetate	33-36	RNA binding motif protein 33	Rattus norvegicus	74-79
22465218-4	2012	In the present study, we found that mangiferin, a glucosylxanthone isolated from Anemarrhena asphodeloides, specifically inhibited MMP-9 gene expression in phorbol myristate acetate (PMA)-stimulated human astroglioma U87MG, U373MG, and CRT-MG cells.	Tetradecanoylphorbol Acetate	156-181	matrix metallopeptidase 9	Homo sapiens	131-136
22465218-4	2012	In the present study, we found that mangiferin, a glucosylxanthone isolated from Anemarrhena asphodeloides, specifically inhibited MMP-9 gene expression in phorbol myristate acetate (PMA)-stimulated human astroglioma U87MG, U373MG, and CRT-MG cells.	Tetradecanoylphorbol Acetate	183-186	matrix metallopeptidase 9	Homo sapiens	131-136
22465218-8	2012	Further mechanistic studies demonstrated that mangiferin inhibits the binding of NF-kappaB and AP-1 to the MMP-9 promoter and suppresses the PMA-induced phosphorylation of Akt and MAP kinases, which are upstream signaling molecules in MMP-9 expression.	Tetradecanoylphorbol Acetate	141-144	matrix metallopeptidase 9	Homo sapiens	235-240
22586032-3	2012	Activation of PKC-theta with PMA promoted Th17 differentiation in wild type (WT) but not PKC-theta(-/-) T cells.	Tetradecanoylphorbol Acetate	29-32	protein kinase C, theta	Mus musculus	14-23
22416134-2	2012	In this study, we discovered that K-bZIP interacts with histone deacetylase (HDAC) 1/2 in 12-O-tetradecanoylphorbol-13-acetate-stimulated BCBL-1 lymphocyte cells.	Tetradecanoylphorbol Acetate	90-126	histone deacetylase 9	Homo sapiens	56-75
22416134-2	2012	In this study, we discovered that K-bZIP interacts with histone deacetylase (HDAC) 1/2 in 12-O-tetradecanoylphorbol-13-acetate-stimulated BCBL-1 lymphocyte cells.	Tetradecanoylphorbol Acetate	90-126	histone deacetylase 9	Homo sapiens	77-81
22174178-1	2012	Phorbol-12-myristate-13-acetate (PMA), a protein kinase C(PKC) activator, can modulate 1alpha, 25 dihydroxyvitamin D(3) (1,25(OH)(2)D(3))-induced expression of the 24-hydroxylase (CYP24A1) gene but this has not been studied in differentiated enterocytes, a primary 1,25(OH)(2) D(3) target cell.	Tetradecanoylphorbol Acetate	0-31	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	180-187
22357618-5	2012	We found that miR-212 was up-regulated when cells were treated with 4ss-12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	110-113	microRNA 212	Homo sapiens	14-21
22230807-6	2012	In addition, the phorbol ester PMA alone or in combination with ionomycin induced a stronger increase in threonine phosphorylation of S100A9 in SLE than in Normal PBMCs, while the same stimuli caused the opposite effect on phosphorylation and activation of Erk1/2, suggesting the existence of an abnormal S100A9 signaling in SLE PBMCs.	Tetradecanoylphorbol Acetate	31-34	S100 calcium binding protein A9	Homo sapiens	134-140
22230807-6	2012	In addition, the phorbol ester PMA alone or in combination with ionomycin induced a stronger increase in threonine phosphorylation of S100A9 in SLE than in Normal PBMCs, while the same stimuli caused the opposite effect on phosphorylation and activation of Erk1/2, suggesting the existence of an abnormal S100A9 signaling in SLE PBMCs.	Tetradecanoylphorbol Acetate	31-34	S100 calcium binding protein A9	Homo sapiens	305-311
22289359-6	2012	Next, five azole-type fungicides, showing ROR inverse agonist activity, were tested on IL-17 mRNA expression in mouse T lymphoma EL4 cells treated with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	152-177	interleukin 17A	Mus musculus	87-92
22223848-0	2012	Loss of the platelet activating factor receptor in mice augments PMA-induced inflammation and cutaneous chemical carcinogenesis.	Tetradecanoylphorbol Acetate	65-68	platelet-activating factor receptor	Mus musculus	12-47
22223848-5	2012	While PAF receptor knockout mice (PAFR(-/-)) showed an expected but modest reduction in the acute inflammatory response to phorbol 12-myristate 13-acetate (PMA), these mice exhibited a surprising increase in inflammation following chronic PMA application.	Tetradecanoylphorbol Acetate	123-154	patchy fur	Mus musculus	6-9
22223848-5	2012	While PAF receptor knockout mice (PAFR(-/-)) showed an expected but modest reduction in the acute inflammatory response to phorbol 12-myristate 13-acetate (PMA), these mice exhibited a surprising increase in inflammation following chronic PMA application.	Tetradecanoylphorbol Acetate	123-154	platelet-activating factor receptor	Mus musculus	34-38
22223848-5	2012	While PAF receptor knockout mice (PAFR(-/-)) showed an expected but modest reduction in the acute inflammatory response to phorbol 12-myristate 13-acetate (PMA), these mice exhibited a surprising increase in inflammation following chronic PMA application.	Tetradecanoylphorbol Acetate	156-159	patchy fur	Mus musculus	6-9
22052014-2	2012	Our earlier studies have shown that mitogenic agent phorbol 12-myristate 13-acetate (PMA) induces the expression of NHE2 through activation of transcription factor early growth response-1 (Egr-1) and its interactions with the NHE2 promoter.	Tetradecanoylphorbol Acetate	52-83	solute carrier family 9 member A2	Homo sapiens	116-120
22052014-2	2012	Our earlier studies have shown that mitogenic agent phorbol 12-myristate 13-acetate (PMA) induces the expression of NHE2 through activation of transcription factor early growth response-1 (Egr-1) and its interactions with the NHE2 promoter.	Tetradecanoylphorbol Acetate	52-83	solute carrier family 9 member A2	Homo sapiens	226-230
22052014-2	2012	Our earlier studies have shown that mitogenic agent phorbol 12-myristate 13-acetate (PMA) induces the expression of NHE2 through activation of transcription factor early growth response-1 (Egr-1) and its interactions with the NHE2 promoter.	Tetradecanoylphorbol Acetate	85-88	solute carrier family 9 member A2	Homo sapiens	116-120
22052014-2	2012	Our earlier studies have shown that mitogenic agent phorbol 12-myristate 13-acetate (PMA) induces the expression of NHE2 through activation of transcription factor early growth response-1 (Egr-1) and its interactions with the NHE2 promoter.	Tetradecanoylphorbol Acetate	85-88	solute carrier family 9 member A2	Homo sapiens	226-230
22052014-5	2012	We show that, in response to PMA, PKCdelta, a member of novel PKC isozymes, and MEK-ERK1/2 pathway of mitogen-activated protein kinases stimulate the NHE2 expression in C2BBe1 intestinal epithelial cells.	Tetradecanoylphorbol Acetate	29-32	solute carrier family 9 member A2	Homo sapiens	150-154
22092277-6	2012	Phorbol myristate acetate (100 nmol/L, 10 min) induced the translocation of the PKCalpha, betaI, betaII, delta and epsilon isoforms, whereas 48 h pretreatment of cells with 1 mumol/L Scu significantly inhibited PMA-induced PKCbetaI, betaII and delta translocation.	Tetradecanoylphorbol Acetate	0-25	protein kinase C, alpha	Rattus norvegicus	80-88
22092277-6	2012	Phorbol myristate acetate (100 nmol/L, 10 min) induced the translocation of the PKCalpha, betaI, betaII, delta and epsilon isoforms, whereas 48 h pretreatment of cells with 1 mumol/L Scu significantly inhibited PMA-induced PKCbetaI, betaII and delta translocation.	Tetradecanoylphorbol Acetate	211-214	protein kinase C, alpha	Rattus norvegicus	80-88
22382313-2	2012	The present study was performed to determine the anti-invasive effect of Kalopanaxsaponin A (KPS-A) on matrix metalloproteinase-9 (MMP-9)-meidated invasion in phorbol 12-myristate 13-acetate (PMA)-stimulated human oral squamous cell carcinoma (OSCC) cells and a murine xenograft model of human OSCC.	Tetradecanoylphorbol Acetate	159-190	matrix metallopeptidase 9	Homo sapiens	103-129
22382313-2	2012	The present study was performed to determine the anti-invasive effect of Kalopanaxsaponin A (KPS-A) on matrix metalloproteinase-9 (MMP-9)-meidated invasion in phorbol 12-myristate 13-acetate (PMA)-stimulated human oral squamous cell carcinoma (OSCC) cells and a murine xenograft model of human OSCC.	Tetradecanoylphorbol Acetate	159-190	matrix metallopeptidase 9	Homo sapiens	131-136
22382313-2	2012	The present study was performed to determine the anti-invasive effect of Kalopanaxsaponin A (KPS-A) on matrix metalloproteinase-9 (MMP-9)-meidated invasion in phorbol 12-myristate 13-acetate (PMA)-stimulated human oral squamous cell carcinoma (OSCC) cells and a murine xenograft model of human OSCC.	Tetradecanoylphorbol Acetate	192-195	matrix metallopeptidase 9	Homo sapiens	103-129
22382313-2	2012	The present study was performed to determine the anti-invasive effect of Kalopanaxsaponin A (KPS-A) on matrix metalloproteinase-9 (MMP-9)-meidated invasion in phorbol 12-myristate 13-acetate (PMA)-stimulated human oral squamous cell carcinoma (OSCC) cells and a murine xenograft model of human OSCC.	Tetradecanoylphorbol Acetate	192-195	matrix metallopeptidase 9	Homo sapiens	131-136
22382313-4	2012	KPS-A treatment reduced the stability of PMA-induced MMP-9 mRNA and inhibited the PMA-induced cytoplasmic translocation of HuR.	Tetradecanoylphorbol Acetate	41-44	matrix metallopeptidase 9	Homo sapiens	53-58
22523472-7	2012	HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-kappaB.	Tetradecanoylphorbol Acetate	57-88	matrix metallopeptidase 9	Homo sapiens	127-132
22523472-7	2012	HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-kappaB.	Tetradecanoylphorbol Acetate	90-93	matrix metallopeptidase 9	Homo sapiens	127-132
22523472-8	2012	We found that resveratrol efficiently reversed the PMA-induced MMP-9 secretion and COX-2 expression.	Tetradecanoylphorbol Acetate	51-54	matrix metallopeptidase 9	Homo sapiens	63-68
25374685-3	2012	AP1 binds specifically to 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive element 5"-TGAG/CTCA-3" (AP1 site).	Tetradecanoylphorbol Acetate	26-62	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-3
25374685-3	2012	AP1 binds specifically to 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive element 5"-TGAG/CTCA-3" (AP1 site).	Tetradecanoylphorbol Acetate	26-62	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-108
25374685-3	2012	AP1 binds specifically to 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive element 5"-TGAG/CTCA-3" (AP1 site).	Tetradecanoylphorbol Acetate	64-67	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-3
25374685-3	2012	AP1 binds specifically to 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive element 5"-TGAG/CTCA-3" (AP1 site).	Tetradecanoylphorbol Acetate	64-67	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-108
22293298-0	2012	The cadin-2-en-1beta-ol-1beta-D-glucuronopyranoside suppresses TPA-mediated matrix metalloproteinase-9 expression through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells.	Tetradecanoylphorbol Acetate	63-66	matrix metallopeptidase 9	Homo sapiens	76-102
22293298-6	2012	Zymographic analysis showed that CR4-1 suppressed TPA-induced MMP-9 activity in a dose-dependent manner.	Tetradecanoylphorbol Acetate	50-53	matrix metallopeptidase 9	Homo sapiens	62-67
22416475-5	2012	Th1/Th2 and Tc1/Tc2 were determined by analyzing intracellular cytokine staining for IFN-gamma and IL-4 in blood CD4+ and CD8+ T cells using flow cytometry after stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	179-182	negative elongation factor complex member C/D	Homo sapiens	0-3
22629859-2	2012	Besides it phorbol-12-myristate 13-acetate was shown possible to modulate promoter activity of TsPO - protein that is involved in steroidogenesis and cell proliferation regulation.	Tetradecanoylphorbol Acetate	11-42	translocator protein	Homo sapiens	95-99
22629859-3	2012	Caspase-3 and TsPO expression was measured in squamous cell carcinoma cells after incubation with phorbol-12-myristate 13-acetate and ultraviolet radiation.	Tetradecanoylphorbol Acetate	98-129	translocator protein	Homo sapiens	14-18
23300800-7	2012	We also observed a strong synergistic activation of AP-1 pathway when using butyrate with PMA, a PKC activator.	Tetradecanoylphorbol Acetate	90-93	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-56
23300800-8	2012	Moreover, butyrate enhanced the PMA-induced expression of c-fos and ERK1/2 phosphorylation, but not p38 and JNK.	Tetradecanoylphorbol Acetate	32-35	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-63
22879913-3	2012	Although it has been widely noted that interferon-beta (IFNbeta) downregulates both the basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression at the transcriptional level, the molecular mechanism of this repression is poorly understood.	Tetradecanoylphorbol Acetate	98-129	matrix metallopeptidase 9	Homo sapiens	144-149
22879913-3	2012	Although it has been widely noted that interferon-beta (IFNbeta) downregulates both the basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression at the transcriptional level, the molecular mechanism of this repression is poorly understood.	Tetradecanoylphorbol Acetate	131-134	matrix metallopeptidase 9	Homo sapiens	144-149
22253701-13	2012	Our data demonstrate that FFL cDNA sequence mediates the TPA-induced transcriptional activity, which is inhibited by T3/TR.	Tetradecanoylphorbol Acetate	57-60	solute carrier family 25 member 5	Homo sapiens	117-122
21937661-6	2011	We identified a subset of CD8(+) T cells refractory to phorbol 12-myristate 13-acetate plus ionomycin-induced ERK1/2 phosphorylation (referred to as p-ERK1/2-refractory cells) that was greatly expanded in HIV-1-infected adults.	Tetradecanoylphorbol Acetate	55-86	CD8a molecule	Homo sapiens	26-29
21400615-6	2011	Importantly, 5"-NIO inhibited Pin1 phosphorylation at serine 16 induced by EGF or TPA, respectively, resulted in the inhibition of interaction between Pin1 and Raf-1.	Tetradecanoylphorbol Acetate	82-85	v-raf-leukemia viral oncogene 1	Mus musculus	160-165
21400615-8	2011	Together, these findings suggest that 5"-NIO might act as an anticarcinogene in EGF- or TPA-induced carcinogenesis through the inhibition of interaction between Pin1 and Raf-1.	Tetradecanoylphorbol Acetate	88-91	v-raf-leukemia viral oncogene 1	Mus musculus	170-175
21890901-5	2011	Reactivation of viral expression in YR2 cells by the phorbol 12-myristate 13-acetate (PMA) plus ionomycin combination was accompanied by a rapid but transient chromatin remodeling in the 5"-LTR, leading to an increased PU.1 and USF-1/USF-2 recruitment in vivo sustained by PMA/ionomycin-mediated USF phosphorylation.	Tetradecanoylphorbol Acetate	53-84	upstream transcription factor 2, c-fos interacting	Homo sapiens	234-239
21890901-5	2011	Reactivation of viral expression in YR2 cells by the phorbol 12-myristate 13-acetate (PMA) plus ionomycin combination was accompanied by a rapid but transient chromatin remodeling in the 5"-LTR, leading to an increased PU.1 and USF-1/USF-2 recruitment in vivo sustained by PMA/ionomycin-mediated USF phosphorylation.	Tetradecanoylphorbol Acetate	86-89	upstream transcription factor 2, c-fos interacting	Homo sapiens	234-239
21871883-5	2011	In this study we investigated the effect of A771726, the active metabolite of leflunomide, on expression of CD147 and on the gelatinolytic activity of MMP-2 and MMP-9 in phorbol myristate acetate (PMA) differentiated THP-1 cells.	Tetradecanoylphorbol Acetate	170-195	matrix metallopeptidase 9	Homo sapiens	161-166
21795061-7	2011	Ketamine and MK-801 decreased TH1 cells, TH2 cells, IFN-gamma and IL-4 levels but increased the ratio of TH1/TH2 and IFN-gamma/IL-4 in the presence of PMA and ionomycin.	Tetradecanoylphorbol Acetate	151-154	negative elongation factor complex member C/D	Homo sapiens	105-108
21745711-0	2011	Induction of lysophosphatidic acid receptor-3 by 12-O-tetradecanoylphorbol-13-acetate stimulates cell migration of rat liver cells.	Tetradecanoylphorbol Acetate	49-85	lysophosphatidic acid receptor 3	Rattus norvegicus	13-45
21745711-5	2011	The expressions of the LPA receptor-3 (Lpar3) gene were significantly elevated in WB-F344 and RH7777 cells treated by TPA, but not Lpar1 and Lpar2 genes.	Tetradecanoylphorbol Acetate	118-121	lysophosphatidic acid receptor 3	Rattus norvegicus	23-37
21745711-5	2011	The expressions of the LPA receptor-3 (Lpar3) gene were significantly elevated in WB-F344 and RH7777 cells treated by TPA, but not Lpar1 and Lpar2 genes.	Tetradecanoylphorbol Acetate	118-121	lysophosphatidic acid receptor 3	Rattus norvegicus	39-44
21689256-3	2011	Phorbol 12-myristate 13-acetate (PMA) is known to enhance the percentage of fusion-competent vesicles and this is mediated by protein kinase C (PKC)-independent Munc13-1 activation and PKC-dependent dissociation of Munc18-1 from syntaxin 1a.	Tetradecanoylphorbol Acetate	0-31	syntaxin binding protein 1	Homo sapiens	215-223
21689256-3	2011	Phorbol 12-myristate 13-acetate (PMA) is known to enhance the percentage of fusion-competent vesicles and this is mediated by protein kinase C (PKC)-independent Munc13-1 activation and PKC-dependent dissociation of Munc18-1 from syntaxin 1a.	Tetradecanoylphorbol Acetate	33-36	syntaxin binding protein 1	Homo sapiens	215-223
22272060-3	2011	In the present study, we investigated whether LPA(3) is involved in cell migration of mouse lung tumor cells stimulated by TPA.	Tetradecanoylphorbol Acetate	123-126	lysophosphatidic acid receptor 3	Mus musculus	46-52
21480395-10	2011	We also performed ELISAs and discovered significant up-regulation of IL-8 and VEGF secretion by UMSCC 11A after treatment with phorbol 12-myristate 13-acetate, tumor necrosis factor alpha, and CSC, which was down-regulated by the A-Fos dominant negative protein.	Tetradecanoylphorbol Acetate	127-158	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	232-235
21805048-0	2011	Radix clematidis extract inhibits TPA-induced MMP-9 expression by suppressing NF-kappaB activation in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	34-37	matrix metallopeptidase 9	Homo sapiens	46-51
21805048-3	2011	The purpose of the present study was to investigate the effects of RCE on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells.	Tetradecanoylphorbol Acetate	74-111	matrix metallopeptidase 9	Homo sapiens	126-131
21805048-3	2011	The purpose of the present study was to investigate the effects of RCE on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells.	Tetradecanoylphorbol Acetate	113-116	matrix metallopeptidase 9	Homo sapiens	126-131
21805048-7	2011	Results showed that the expression of MMP-9 and cell invasion in response to TPA was increased, whereas TPA-induced MMP-9 expression and cell invasion was decreased by RCE.	Tetradecanoylphorbol Acetate	104-107	matrix metallopeptidase 9	Homo sapiens	116-121
21805048-9	2011	Thus, RCE is a potent inhibitor of TPA-induced MMP-9 expression and markedly blocks the NF-kappaB pathway in MCF-7 cells.	Tetradecanoylphorbol Acetate	35-38	matrix metallopeptidase 9	Homo sapiens	47-52
21467074-5	2011	Phorbol 12-myristate 13-acetate (PMA), which stimulates PKCs, induced p66shc phosphorylation and this was inhibited by a selective PKCbetaII inhibitor.	Tetradecanoylphorbol Acetate	0-31	src homology 2 domain-containing transforming protein C1	Mus musculus	70-76
21467074-5	2011	Phorbol 12-myristate 13-acetate (PMA), which stimulates PKCs, induced p66shc phosphorylation and this was inhibited by a selective PKCbetaII inhibitor.	Tetradecanoylphorbol Acetate	33-36	src homology 2 domain-containing transforming protein C1	Mus musculus	70-76
21467074-8	2011	Moreover, PMA-induced p66shc phosphorylation was augmented in cells in which APE1 was knocked down.	Tetradecanoylphorbol Acetate	10-13	src homology 2 domain-containing transforming protein C1	Mus musculus	22-28
22111068-0	2011	Intra-Arterial Thrombolysis after Full-Dose Intravenous tPA via the "Drip and Ship" Approach in Patients with Acute Ischemic Stroke: Preliminary Report.	Tetradecanoylphorbol Acetate	56-59	inositol polyphosphate-5-phosphatase D	Homo sapiens	78-82
21573487-4	2011	ROS production and MPO release by the PMA-stimulated neutrophils were measured by the lucigenin-enhanced chemiluminescence and ELISA assays, respectively.	Tetradecanoylphorbol Acetate	38-41	myeloperoxidase	Equus caballus	19-22
21631112-5	2011	Similarly, in the murine ear edema model, 12-O-tetradecanoylphorbol-13-acetate-induced inflammation was inhibited by mogrosides by down-regulating COX-2 and IL-6 and up-regulating PARP1, BCL2l1, TRP53, MAPK9, and PPARdelta gene expression.	Tetradecanoylphorbol Acetate	42-78	poly (ADP-ribose) polymerase family, member 1	Mus musculus	180-185
21371509-7	2011	Catalase-loaded PAOX microparticles significantly inhibited hydrogen peroxide generation in Phorbol-12-myristate-13-acetate (PMA)-stimulated macrophages, in a dose-dependent manner.	Tetradecanoylphorbol Acetate	92-123	polyamine oxidase	Homo sapiens	16-20
21371509-7	2011	Catalase-loaded PAOX microparticles significantly inhibited hydrogen peroxide generation in Phorbol-12-myristate-13-acetate (PMA)-stimulated macrophages, in a dose-dependent manner.	Tetradecanoylphorbol Acetate	125-128	polyamine oxidase	Homo sapiens	16-20
21612443-0	2011	Neutrophil gelatinase-associated lipocalin in gastric carcinoma cells and its induction by TPA are controlled by C/EBPbeta.	Tetradecanoylphorbol Acetate	91-94	lipocalin 2	Homo sapiens	0-42
21612443-7	2011	Gastric cancer cells treated with TPA resulted in the transactivation of NGAL promoter and the upregulation of its mRNA and protein levels.	Tetradecanoylphorbol Acetate	34-37	lipocalin 2	Homo sapiens	73-77
21612443-8	2011	We identified the -110 to -79 sequence segment upstream from the transcription initiation site of NGAL as a TPA responsive element (TRE) and confirmed that C/EBPbeta was able to bind to the -87 to -79 segment.	Tetradecanoylphorbol Acetate	108-111	lipocalin 2	Homo sapiens	98-102
21612443-10	2011	These results suggest that NGAL is overexpressed in gastric cancer, the binding of C/EBPbeta to the TRE of its gene promoter mediates its TPA-induced overexpression in gastric carcinoma cells.	Tetradecanoylphorbol Acetate	138-141	lipocalin 2	Homo sapiens	27-31
21402126-9	2011	Yet the presence of isoflurane caused PMA (but not MCh) to enhance Ca(v)2.1 currents.	Tetradecanoylphorbol Acetate	38-41	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit S homeolog	Xenopus laevis	67-75
21499124-6	2011	Binding activity to ULBP1 promoter region of AP-2alpha, which suggested as suppressor of expression of ULBP1, was decreased by treatment with EGFR inhibitors, and restored by pretreatment with phorbol 12-myristate 13-acetate in A549 and SW-900.	Tetradecanoylphorbol Acetate	193-224	transcription factor AP-2 alpha	Homo sapiens	45-54
21089054-5	2011	We found that acteoside suppresses phorbol-12-myristate-13-acetate (PMA)-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB activation.	Tetradecanoylphorbol Acetate	68-71	matrix metallopeptidase 9	Homo sapiens	110-115
21186251-6	2011	BAS 02104951 also inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Elk-1 phosphorylation in HeLa cells, translocation of PKCepsilon and PKCeta to the membrane following treatment of PC3 cells with TPA.	Tetradecanoylphorbol Acetate	28-64	ETS transcription factor ELK1	Homo sapiens	79-84
21186251-6	2011	BAS 02104951 also inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Elk-1 phosphorylation in HeLa cells, translocation of PKCepsilon and PKCeta to the membrane following treatment of PC3 cells with TPA.	Tetradecanoylphorbol Acetate	66-69	ETS transcription factor ELK1	Homo sapiens	79-84
21262201-4	2011	MMP-9 expression and cell invasion in response to 12-O-tetradecanoylphorbol-13-acetate (TPA) was increased, whereas these inductions were muted by DHAvD.	Tetradecanoylphorbol Acetate	50-86	matrix metallopeptidase 9	Homo sapiens	0-5
21262201-4	2011	MMP-9 expression and cell invasion in response to 12-O-tetradecanoylphorbol-13-acetate (TPA) was increased, whereas these inductions were muted by DHAvD.	Tetradecanoylphorbol Acetate	88-91	matrix metallopeptidase 9	Homo sapiens	0-5
21262201-6	2011	The results indicate that DHAvD-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the MAPK/NF-kappaB and MAPK/AP-1 pathways in MCF-7 cells.	Tetradecanoylphorbol Acetate	55-58	matrix metallopeptidase 9	Homo sapiens	67-72
21093509-2	2011	Herein, we report the differential modulation of protein kinase C (PKC)-associated proteins by TH2-3, and the PKC activator, phorbol 12-myristate 13-acetate (PMA), in RAW264.7 macrophages.	Tetradecanoylphorbol Acetate	125-156	protein kinase C, delta	Mus musculus	67-70
21093509-2	2011	Herein, we report the differential modulation of protein kinase C (PKC)-associated proteins by TH2-3, and the PKC activator, phorbol 12-myristate 13-acetate (PMA), in RAW264.7 macrophages.	Tetradecanoylphorbol Acetate	158-161	protein kinase C, delta	Mus musculus	67-70
21415525-0	2011	Tumor necrosis factor-alpha-nuclear factor-kappa B-signaling enhances St2b2 expression during 12-O-tetradecanoylphorbol-13-acetate-induced epidermal hyperplasia.	Tetradecanoylphorbol Acetate	94-130	sulfotransferase family 1B, member 1	Mus musculus	70-75
21415525-2	2011	12-O-Tetradecanoylphorbol-13-acetate (TPA) causes epidermal hyperplasia, an abnormal increase in epidermal cell numbers resulting from aberrant cell differentiation and an increase in St2b2 protein levels.	Tetradecanoylphorbol Acetate	0-36	sulfotransferase family 1B, member 1	Mus musculus	184-189
21415525-2	2011	12-O-Tetradecanoylphorbol-13-acetate (TPA) causes epidermal hyperplasia, an abnormal increase in epidermal cell numbers resulting from aberrant cell differentiation and an increase in St2b2 protein levels.	Tetradecanoylphorbol Acetate	38-41	sulfotransferase family 1B, member 1	Mus musculus	184-189
21625419-5	2011	Human brain microvascular endothelial cells were treated with a combination of phorbol 12-myristate 13-acetate (PMA), a carcinogen documented to increase MMP-9 and COX-2 through NF-kappaB, and several naturally occurring flavonoids.	Tetradecanoylphorbol Acetate	112-115	matrix metallopeptidase 9	Homo sapiens	154-159
20339310-8	2011	PKCtheta pseudosubstrate significantly reduced the phorbol 3-myristate 12-acetate (PMA)-induced phosphorylation of ERK.	Tetradecanoylphorbol Acetate	83-86	protein kinase C, theta	Mus musculus	0-8
20718733-5	2010	The suppressive effects of 6-shogaol on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) gelatinolytic activity and nuclear factor-kappaB (NF-kappaB) activation were further determined.	Tetradecanoylphorbol Acetate	40-71	matrix metallopeptidase 9	Homo sapiens	86-112
20718733-5	2010	The suppressive effects of 6-shogaol on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) gelatinolytic activity and nuclear factor-kappaB (NF-kappaB) activation were further determined.	Tetradecanoylphorbol Acetate	40-71	matrix metallopeptidase 9	Homo sapiens	114-119
20718733-5	2010	The suppressive effects of 6-shogaol on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) gelatinolytic activity and nuclear factor-kappaB (NF-kappaB) activation were further determined.	Tetradecanoylphorbol Acetate	73-76	matrix metallopeptidase 9	Homo sapiens	86-112
20718733-5	2010	The suppressive effects of 6-shogaol on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) gelatinolytic activity and nuclear factor-kappaB (NF-kappaB) activation were further determined.	Tetradecanoylphorbol Acetate	73-76	matrix metallopeptidase 9	Homo sapiens	114-119
20670683-5	2010	NCX (1 nM-50 muM) dose-dependently inhibited phorbol 12-myristate 13-acetate (PMA)-induced TNF-alpha release from monocytes (IC(50)=240 nM) and MDM (IC(50)=52 nM).	Tetradecanoylphorbol Acetate	45-76	T cell leukemia homeobox 2	Homo sapiens	0-3
20923877-3	2010	LMP1 TES2 activated NF-kappaB in Jurkat cell lines harboring NEMO truncated at 372 (A45) or NEMO with an in-frame deletion of 133-224 (2C), whereas TNFalpha, 12-O-Tetradecanoylphorbol-13-acetate, human T-cell leukemia virus 1 Tax, and CD40 did not.	Tetradecanoylphorbol Acetate	158-194	PDZ and LIM domain 7	Homo sapiens	0-4
20832999-2	2010	Indeed, the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA) induces biphasic PKD activation, which mirrors the biphasic response of initial differentiation followed by proliferation and tumor promotion seen in TPA-treated keratinocytes in vitro and epidermis in vivo.	Tetradecanoylphorbol Acetate	42-78	protein kinase D1	Homo sapiens	102-105
20832999-2	2010	Indeed, the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA) induces biphasic PKD activation, which mirrors the biphasic response of initial differentiation followed by proliferation and tumor promotion seen in TPA-treated keratinocytes in vitro and epidermis in vivo.	Tetradecanoylphorbol Acetate	80-83	protein kinase D1	Homo sapiens	102-105
20832999-2	2010	Indeed, the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA) induces biphasic PKD activation, which mirrors the biphasic response of initial differentiation followed by proliferation and tumor promotion seen in TPA-treated keratinocytes in vitro and epidermis in vivo.	Tetradecanoylphorbol Acetate	235-238	protein kinase D1	Homo sapiens	102-105
20832999-3	2010	OBJECTIVE: Our objective was to test the idea that PKD"s pro-proliferative and/or anti-differentiative effects in keratinocytes contribute to TPA-induced tumorigenesis.	Tetradecanoylphorbol Acetate	142-145	protein kinase D1	Homo sapiens	51-54
20832999-10	2010	The protein kinase C/PKD inhibitor Go6976 blocked the increase in proliferation (as measured by DNA specific activity) induced by chronic TPA without affecting the initial TPA-elicited differentiation.	Tetradecanoylphorbol Acetate	138-141	protein kinase D1	Homo sapiens	21-24
20403427-4	2010	Here, we show that co-expression of the Gbetagamma dimer decreased phorbol 12-myristate 13-acetate (PMA)-stimulated AP-1 gene reporter activity in HEK293 cells as well as the AP-1 dependent gonadotropin-releasing hormone-stimulated human follicle-stimulating hormone beta reporter activity in LbetaT2 gonadotrope cells.	Tetradecanoylphorbol Acetate	67-98	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-120
20403427-4	2010	Here, we show that co-expression of the Gbetagamma dimer decreased phorbol 12-myristate 13-acetate (PMA)-stimulated AP-1 gene reporter activity in HEK293 cells as well as the AP-1 dependent gonadotropin-releasing hormone-stimulated human follicle-stimulating hormone beta reporter activity in LbetaT2 gonadotrope cells.	Tetradecanoylphorbol Acetate	100-103	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-120
19761816-6	2010	Activation of PKC with either phorbol 12-myristate 13-acetate or thrombin enhanced AQP4 phosphorylation, reduced water permeability and significantly decreased cell invasion.	Tetradecanoylphorbol Acetate	30-61	aquaporin 4	Homo sapiens	83-87
20442406-4	2010	In this study, we report that ectopic expression of HA-PRMT1 in K562 cells suppressed phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic differentiation as demonstrated by changes in cytological characteristics, adhesive properties, and CD41 expression, whereas knockdown of PRMT1 by small interference RNA promoted differentiation.	Tetradecanoylphorbol Acetate	86-117	protein arginine methyltransferase 1	Homo sapiens	55-60
20442406-4	2010	In this study, we report that ectopic expression of HA-PRMT1 in K562 cells suppressed phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic differentiation as demonstrated by changes in cytological characteristics, adhesive properties, and CD41 expression, whereas knockdown of PRMT1 by small interference RNA promoted differentiation.	Tetradecanoylphorbol Acetate	86-117	integrin subunit alpha 2b	Homo sapiens	247-251
20442406-4	2010	In this study, we report that ectopic expression of HA-PRMT1 in K562 cells suppressed phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic differentiation as demonstrated by changes in cytological characteristics, adhesive properties, and CD41 expression, whereas knockdown of PRMT1 by small interference RNA promoted differentiation.	Tetradecanoylphorbol Acetate	86-117	protein arginine methyltransferase 1	Homo sapiens	285-290
20442406-4	2010	In this study, we report that ectopic expression of HA-PRMT1 in K562 cells suppressed phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic differentiation as demonstrated by changes in cytological characteristics, adhesive properties, and CD41 expression, whereas knockdown of PRMT1 by small interference RNA promoted differentiation.	Tetradecanoylphorbol Acetate	119-122	protein arginine methyltransferase 1	Homo sapiens	55-60
20442406-4	2010	In this study, we report that ectopic expression of HA-PRMT1 in K562 cells suppressed phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic differentiation as demonstrated by changes in cytological characteristics, adhesive properties, and CD41 expression, whereas knockdown of PRMT1 by small interference RNA promoted differentiation.	Tetradecanoylphorbol Acetate	119-122	integrin subunit alpha 2b	Homo sapiens	247-251
20442406-4	2010	In this study, we report that ectopic expression of HA-PRMT1 in K562 cells suppressed phorbol 12-myristate 13-acetate (PMA)-induced megakaryocytic differentiation as demonstrated by changes in cytological characteristics, adhesive properties, and CD41 expression, whereas knockdown of PRMT1 by small interference RNA promoted differentiation.	Tetradecanoylphorbol Acetate	119-122	protein arginine methyltransferase 1	Homo sapiens	285-290
20566912-6	2010	In addition, we evaluated the effect of 4 physiologically relevant agents, including retinoic acid, interleukin 1beta, phorbol 12-myristate 13-acetate (PMA), and dexamethasone, on the expression of MUC4 and MUC16 in HNPE cells at the gene and protein levels.	Tetradecanoylphorbol Acetate	119-150	mucin 16, cell surface associated	Homo sapiens	207-212
20566912-11	2010	Dexamethasone and PMA are potent mediators for the expression of MUC16 in nasal polyps.	Tetradecanoylphorbol Acetate	18-21	mucin 16, cell surface associated	Homo sapiens	65-70
20308057-7	2010	Analysis of Ras isoforms showed that both H-Ras and N-Ras depended on RasGRP1 for activation by TPA, whereas activation of K-Ras could not be detected.	Tetradecanoylphorbol Acetate	96-99	Harvey rat sarcoma virus oncogene	Mus musculus	42-47
20308057-7	2010	Analysis of Ras isoforms showed that both H-Ras and N-Ras depended on RasGRP1 for activation by TPA, whereas activation of K-Ras could not be detected.	Tetradecanoylphorbol Acetate	96-99	neuroblastoma ras oncogene	Mus musculus	52-57
20302858-6	2010	Among these human DNA helicase genes, XPB, RecQL5, and RTEL promoters were activated during TPA-induced HL-60 cell differentiation.	Tetradecanoylphorbol Acetate	92-95	ERCC excision repair 3, TFIIH core complex helicase subunit	Homo sapiens	38-41
20331435-4	2010	By using PMA and the phosphatase inhibitors cantharidin and calyculin A, we could selectively activate PKC or p38 MAPK respectively to promote TACE-dependent shedding of L-selectin.	Tetradecanoylphorbol Acetate	9-12	ADAM metallopeptidase domain 17	Homo sapiens	143-147
20178130-8	2010	Following dedifferentiation of chondrocytes or treatment of primary chondrocytes with hyaluronan oligosaccharides, IL-1beta, or phorbol myristate acetate, CD44 fragmentation was enhanced.	Tetradecanoylphorbol Acetate	128-153	CD44 molecule (Indian blood group)	Homo sapiens	155-159
20486934-6	2010	The mumbaistatin analog significantly inhibited the phorbol 12-myristate 13-acetate (PMA)-induced matrix-metalloproteinase (MMP)-9 secretion and gene expression as assessed by zymography and RT-PCR.	Tetradecanoylphorbol Acetate	52-83	matrix metallopeptidase 9	Homo sapiens	98-130
20486934-6	2010	The mumbaistatin analog significantly inhibited the phorbol 12-myristate 13-acetate (PMA)-induced matrix-metalloproteinase (MMP)-9 secretion and gene expression as assessed by zymography and RT-PCR.	Tetradecanoylphorbol Acetate	85-88	matrix metallopeptidase 9	Homo sapiens	98-130
20176111-9	2010	Transient transfection assays indicate that NSC13746 can inhibit the TPA induced activation of two B-ZIP dependent reporters.	Tetradecanoylphorbol Acetate	69-72	death associated protein kinase 3	Homo sapiens	101-104
20188714-4	2010	In addition, gelatin zymography showed that glycitein inhibited the PMA-induced MMP-9 secretion in U87MG cells.	Tetradecanoylphorbol Acetate	68-71	matrix metallopeptidase 9	Homo sapiens	80-85
20188714-6	2010	In support of this, treatment of MMP-3- or MMP-9-specific inhibitor significantly suppressed PMA-induced invasion of glioma cells.	Tetradecanoylphorbol Acetate	93-96	matrix metallopeptidase 9	Homo sapiens	43-48
20158498-7	2010	Whereas numerous mammalian protease inhibitors have no effect on MLK3 proteolysis, blockade of the proteasome through epoxomicin or MG132 abolishes PMA-induced production of the CTF of MLK3.	Tetradecanoylphorbol Acetate	148-151	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	185-189
20360975-6	2010	Phorbol myristate acetate (PMA) upregulated the expression of resistin mRNA in U937 cells by increasing the recruitment of Sp1, ATF-2 and PPARgamma on the resistin gene promoter.	Tetradecanoylphorbol Acetate	0-25	activating transcription factor 2	Homo sapiens	128-133
20360975-6	2010	Phorbol myristate acetate (PMA) upregulated the expression of resistin mRNA in U937 cells by increasing the recruitment of Sp1, ATF-2 and PPARgamma on the resistin gene promoter.	Tetradecanoylphorbol Acetate	27-30	activating transcription factor 2	Homo sapiens	128-133
20163138-6	2010	In contrast, chimera Nox4/2, consisting of the Nox4 TM and Nox2 DH domains, exhibited PMA-dependent activation that required coexpression of regulatory subunits.	Tetradecanoylphorbol Acetate	86-89	cytochrome b-245 beta chain	Homo sapiens	59-63
20007519-6	2010	Coincubation with glutamate agonists and phorbol 12-myristate 13-acetate, a protein kinase C activator, significantly enhanced mean levels of TNF-alpha and RANTES in SW982 cell supernatants compared with incubation with either agent alone.	Tetradecanoylphorbol Acetate	41-72	C-C motif chemokine ligand 5	Homo sapiens	156-162
20179211-5	2010	DATS also diminished TPA-induced expression of c-Jun and c-Fos, the principal components of AP-1, and blunted the activation of c-Jun NH(2)-terminal kinase (JNK) and Akt.	Tetradecanoylphorbol Acetate	21-24	mitogen-activated protein kinase 8	Mus musculus	157-160
20179211-6	2010	Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and c-Fos, and inhibition of COX-2 expression in TPA-treated mouse skin.	Tetradecanoylphorbol Acetate	192-195	mitogen-activated protein kinase 8	Mus musculus	28-31
20179211-7	2010	The JNK or Akt kinase assay, taking c-Jun fusion protein as a substrate, revealed that TPA induced JNK- or Akt-mediated c-Jun phosphorylation in mouse skin, which was significantly attenuated by DATS or respective pharmacologic inhibitors.	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase 8	Mus musculus	4-7
20179211-7	2010	The JNK or Akt kinase assay, taking c-Jun fusion protein as a substrate, revealed that TPA induced JNK- or Akt-mediated c-Jun phosphorylation in mouse skin, which was significantly attenuated by DATS or respective pharmacologic inhibitors.	Tetradecanoylphorbol Acetate	87-90	mitogen-activated protein kinase 8	Mus musculus	99-103
20179211-9	2010	Taken together, the inhibitory effects of DATS on TPA-induced AP-1 activation and COX-2 expression through modulation of JNK or Akt signaling may partly account for its antitumor-promoting effect on mouse skin carcinogenesis.	Tetradecanoylphorbol Acetate	50-53	mitogen-activated protein kinase 8	Mus musculus	121-124
20117839-3	2010	Agilent Mouse Whole Genome microarrays were hybridized with fluorescently labeled total RNA isolated from resting CD4 T cells cultured +/-10(-7)M VIP for 5h or PMA/ionomycin activated CD4 T cells cultured +/-10(-7)M VIP for 5h.	Tetradecanoylphorbol Acetate	160-163	CD4 antigen	Mus musculus	184-187
20032465-8	2010	The PKC activator phorbol 12-myristate 13-acetate partially rescued FTY720-induced down-regulation of the S1P(1) receptor, linking PKC activation with S1P(1) receptor surface expression.	Tetradecanoylphorbol Acetate	18-49	protein kinase C, gamma	Rattus norvegicus	4-7
20032465-8	2010	The PKC activator phorbol 12-myristate 13-acetate partially rescued FTY720-induced down-regulation of the S1P(1) receptor, linking PKC activation with S1P(1) receptor surface expression.	Tetradecanoylphorbol Acetate	18-49	protein kinase C, gamma	Rattus norvegicus	131-134
19969058-10	2010	We confirmed that PMA-induced MMP-9 activity was significantly decreased by melittin, but not by apamin and phospholipase A(2).	Tetradecanoylphorbol Acetate	18-21	matrix metallopeptidase 9	Homo sapiens	30-35
19969058-12	2010	CONCLUSION: Bee venom inhibits PMA-induced MMP-9 expression and activity by inhibition of NF-kappaB via p38 MAPK and JNK signaling pathways in MCF-7 cells.	Tetradecanoylphorbol Acetate	31-34	matrix metallopeptidase 9	Homo sapiens	43-48
20107497-5	2010	Human platelets and their TPA-differentiated precursors expressed a classical 50 kDa VDR protein, which increased with megakaryocytes maturation.	Tetradecanoylphorbol Acetate	26-29	vitamin D receptor	Homo sapiens	85-88
20861614-8	2010	Epithelial cells with increased levels of TACE shed more soluble TNFR2 into culture media and even more after TACE activation by phorbol-12-myristate-13-acetate stimulation.	Tetradecanoylphorbol Acetate	129-160	ADAM metallopeptidase domain 17	Homo sapiens	42-46
20861614-8	2010	Epithelial cells with increased levels of TACE shed more soluble TNFR2 into culture media and even more after TACE activation by phorbol-12-myristate-13-acetate stimulation.	Tetradecanoylphorbol Acetate	129-160	ADAM metallopeptidase domain 17	Homo sapiens	110-114
20119960-5	2010	To demonstrate its utility, this method has been applied to the quantitation of the mRNA levels for two transcription factors, Klf4 and Sox5, and a housekeeping gene, Gapdh, in human leukemia K562 cells before and after induction with phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	235-266	Kruppel like factor 4	Homo sapiens	127-131
19766691-2	2010	In the present study, we show the protein kinase C activator, phorbol myristate acetate (PMA), potently induced mRNA expression and secretion of the C-C chemokine MCP-1 in U937 cells.	Tetradecanoylphorbol Acetate	62-87	chemokine (C-C motif) ligand 2	Mus musculus	163-168
19766691-2	2010	In the present study, we show the protein kinase C activator, phorbol myristate acetate (PMA), potently induced mRNA expression and secretion of the C-C chemokine MCP-1 in U937 cells.	Tetradecanoylphorbol Acetate	89-92	chemokine (C-C motif) ligand 2	Mus musculus	163-168
20492173-0	2010	alpha-Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells.	Tetradecanoylphorbol Acetate	54-57	matrix metallopeptidase 9	Homo sapiens	77-82
20492173-1	2010	This study first investigates the anti-metastatic effect of alpha-mangostin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in human breast adenocarcinoma cells, MCF-7.	Tetradecanoylphorbol Acetate	79-115	matrix metallopeptidase 9	Homo sapiens	169-195
19672103-7	2010	Moreover, calphostin C (a PKC inhibitor) inhibited TGF-beta(1)-induced alpha-SMA expression, whereas phorbol-12-myristate-13-acetate (a PKC activator) induced it.	Tetradecanoylphorbol Acetate	101-132	protein kinase C, alpha	Rattus norvegicus	136-139
19804834-6	2010	Additionally, the natural flavonoids quercetin (QE), baicalein (BE), and myricetin (ME) effectively blocked TPA-induced migration/invasion while simultaneously inhibiting COX-2/PGE(2) production, MMP-9 enzyme activity, and peroxide production in U87 cells.	Tetradecanoylphorbol Acetate	108-111	matrix metallopeptidase 9	Homo sapiens	196-201
19804834-6	2010	Additionally, the natural flavonoids quercetin (QE), baicalein (BE), and myricetin (ME) effectively blocked TPA-induced migration/invasion while simultaneously inhibiting COX-2/PGE(2) production, MMP-9 enzyme activity, and peroxide production in U87 cells.	Tetradecanoylphorbol Acetate	108-111	small nucleolar RNA, C/D box 87	Homo sapiens	246-249
20046424-8	2009	Treatment of cancer cells with phorbol 12-myristate 13-acetate increased the expressions of COX-2 and Snail, decreased 15-hydroxyprostaglandin dehydrogenase expression, and increased the cells" motility.	Tetradecanoylphorbol Acetate	31-62	carbonyl reductase 1	Homo sapiens	119-156
19554423-9	2009	Conversely, activation of PKC by phorbol 12-myristate 13-acetate (PMA) upregulated the ODC/polyamine system, whereas the PKC inhibitor chelerythrine (Che) downregulated the ODC/polyamine system.	Tetradecanoylphorbol Acetate	33-64	protein kinase C, gamma	Rattus norvegicus	26-29
19554423-9	2009	Conversely, activation of PKC by phorbol 12-myristate 13-acetate (PMA) upregulated the ODC/polyamine system, whereas the PKC inhibitor chelerythrine (Che) downregulated the ODC/polyamine system.	Tetradecanoylphorbol Acetate	66-69	protein kinase C, gamma	Rattus norvegicus	26-29
19675305-7	2009	Mutation of a putatively phosphorylated threonine (T504) to aspartic acid within a PKC consensus recognition sequence unique to Kv4.3-L eliminated the PMA response.	Tetradecanoylphorbol Acetate	151-154	potassium channel, voltage gated Shal related subfamily D, member 3 L homeolog	Xenopus laevis	128-133
19759192-3	2009	Using this two-stage chemical carcinogenesis protocol, we found that the development of DMBA/TPA-induced skin tumors was diminished in IL-12p40-knockout mice than in their wild-type counterparts.	Tetradecanoylphorbol Acetate	93-96	interleukin 12b	Mus musculus	135-143
19467330-7	2009	Propranolol significantly reduced MMP-9 secretion upon treatment with the tumor-promoting agent phorbol 12-myristate 13-acetate, while secretion of MMP-2 remained unaffected.	Tetradecanoylphorbol Acetate	96-127	matrix metallopeptidase 9	Homo sapiens	34-39
19559082-7	2009	These results indicated that BaP induced NCF1/p47(phox) expression and subsequently enhanced superoxide anion production in PMA-treated human macrophages, in an AhR-dependent manner; such an NCF1/NADPH oxidase regulation by polycyclic aromatic hydrocarbons may participate in deleterious effects toward human health triggered by these environmental contaminants, including atherosclerosis and smoking-related diseases.	Tetradecanoylphorbol Acetate	124-127	neutrophil cytosolic factor 1	Homo sapiens	191-195
19587094-4	2009	EP2"s contributions to the activation of these pathways and papilloma development were determined by inhibiting endogenous TPA-induced PGE(2) production with indomethacin (Indo) and concomitantly treating with the EP2 agonist, CAY10399 (CAY).	Tetradecanoylphorbol Acetate	123-126	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	0-3
19740314-4	2009	This report confirms, using IL-32 small interfering RNA, that IL-32beta induces an anti-inflammatory cytokine IL-10 in K562-IL-32beta cells and U937 promonocytic cells, which express endogenous IL-32beta upon phorbol 12-myristate 13-acetate (PMA) treatment, and monocyte-derived dendritic cells (DC) upon lipopolysaccharide (LPS) treatment.	Tetradecanoylphorbol Acetate	209-240	interleukin 10	Homo sapiens	110-115
19740314-4	2009	This report confirms, using IL-32 small interfering RNA, that IL-32beta induces an anti-inflammatory cytokine IL-10 in K562-IL-32beta cells and U937 promonocytic cells, which express endogenous IL-32beta upon phorbol 12-myristate 13-acetate (PMA) treatment, and monocyte-derived dendritic cells (DC) upon lipopolysaccharide (LPS) treatment.	Tetradecanoylphorbol Acetate	242-245	interleukin 10	Homo sapiens	110-115
19541923-12	2009	Ectopic expression of c-Jun/c-Fos or p300 or treatment of cells with phorbol 12-myristate 13-acetate (PMA) stimulated endogenous TFF2 mRNA expression and promoter activity, and p53 inhibited the effects of AP-1 and PMA on TFF2.	Tetradecanoylphorbol Acetate	102-105	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	22-27
19420016-0	2009	Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	28-31	matrix metallopeptidase 9	Homo sapiens	61-87
19420016-2	2009	We investigated the inhibitory effect of kalopanaxsaponin A (KPS-A) on cell invasion and MMP-9 activation in phorbol 12-myristate 13-acetate (PMA)-treated MCF-7 human breast cancer cells.	Tetradecanoylphorbol Acetate	142-145	matrix metallopeptidase 9	Homo sapiens	89-94
19420016-4	2009	PMA-induced cell invasion was blocked in the presence of a primary antibody of MMP-9, and KPS-A suppressed the increased expression and/or secretion of MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	79-84
19420016-5	2009	Using specific inhibitors, we confirmed that PMA-induced cell invasion and MMP-9 expression is primarily regulated by nuclear factor-kappa B (NF-kappaB) activation via phosphatidylinositol 3-kinase (PI3K)/Akt and activator protein-1 (AP-1) activation via extracellular signal-regulated kinase (ERK)1/2.	Tetradecanoylphorbol Acetate	45-48	matrix metallopeptidase 9	Homo sapiens	75-80
19205902-3	2009	In current manuscript, using THP-1 cells, a human monocytic cell line, we found that ATP7A expression was increased in cells exposed to phorbol-12-myristate-13-acetate (PMA), a potent inducer of neovascularization and cancer.	Tetradecanoylphorbol Acetate	136-167	ATPase copper transporting alpha	Homo sapiens	85-90
19205902-3	2009	In current manuscript, using THP-1 cells, a human monocytic cell line, we found that ATP7A expression was increased in cells exposed to phorbol-12-myristate-13-acetate (PMA), a potent inducer of neovascularization and cancer.	Tetradecanoylphorbol Acetate	169-172	ATPase copper transporting alpha	Homo sapiens	85-90
19205902-6	2009	PMA treatment in THP-1 cells resulted in increased expression of matrix metalloproteinase (MMP) 9 and vascular endothelial growth factor receptor 1 (VEGFR1), whereas inhibition of ATP7A resulted in suppression of PMA-induced expression of VEGFR1, but not MMP9.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	65-97
19205902-6	2009	PMA treatment in THP-1 cells resulted in increased expression of matrix metalloproteinase (MMP) 9 and vascular endothelial growth factor receptor 1 (VEGFR1), whereas inhibition of ATP7A resulted in suppression of PMA-induced expression of VEGFR1, but not MMP9.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	255-259
19205902-8	2009	Collectively, we demonstrate that PMA induces copper egress in THP-1 cells, which is regulated by ATP7A, and ATP7A regulates VEGFR1 expression.	Tetradecanoylphorbol Acetate	34-37	ATPase copper transporting alpha	Homo sapiens	98-103
19333010-0	2009	Activation of protein kinase C by phorbol 12-myristate 13-acetate suppresses the growth of lung cancer cells through KLF6 induction.	Tetradecanoylphorbol Acetate	34-65	Kruppel like factor 6	Homo sapiens	117-121
19333010-5	2009	Moreover, PMA induced cell growth arrest through KLF6 induction in H358 NSCLC cells.	Tetradecanoylphorbol Acetate	10-13	Kruppel like factor 6	Homo sapiens	49-53
19333010-6	2009	The increase in KLF6 by PMA was associated with upregulation of the cyclin-dependent kinase inhibitors (CDKIs) p21(WAF1/CIP1) and p27(KIP1).	Tetradecanoylphorbol Acetate	24-27	Kruppel like factor 6	Homo sapiens	16-20
19366675-3	2009	Here, we report that in embryonic zebrafish, the activation of PKCgamma by phorbol 12-myristate 13-acetate, strongly potentiates the amplitude of AMPAR-mediated miniature excitatory postsynaptic currents (AMPA-mEPSCs) via a N-ethylmaleimide-sensitive fusion (NSF) and protein interacting with C-kinase-1 (PICK1)-dependent process.	Tetradecanoylphorbol Acetate	75-106	N-ethylmaleimide-sensitive factor a	Danio rerio	259-262
19366675-3	2009	Here, we report that in embryonic zebrafish, the activation of PKCgamma by phorbol 12-myristate 13-acetate, strongly potentiates the amplitude of AMPAR-mediated miniature excitatory postsynaptic currents (AMPA-mEPSCs) via a N-ethylmaleimide-sensitive fusion (NSF) and protein interacting with C-kinase-1 (PICK1)-dependent process.	Tetradecanoylphorbol Acetate	75-106	protein interacting with prkca 1	Danio rerio	268-303
19366675-3	2009	Here, we report that in embryonic zebrafish, the activation of PKCgamma by phorbol 12-myristate 13-acetate, strongly potentiates the amplitude of AMPAR-mediated miniature excitatory postsynaptic currents (AMPA-mEPSCs) via a N-ethylmaleimide-sensitive fusion (NSF) and protein interacting with C-kinase-1 (PICK1)-dependent process.	Tetradecanoylphorbol Acetate	75-106	protein interacting with prkca 1	Danio rerio	305-310
19338776-7	2009	Runx3 inhibited IL-4 production in EL-4 T cells stimulated with PMA/ionomycin.	Tetradecanoylphorbol Acetate	64-67	runt related transcription factor 3	Mus musculus	0-5
19092850-6	2009	In contrast, TPA increased the level of manganese superoxide dismutase, which catalyzes the dismutation of superoxide into H(2)O(2) and O(2) without affecting the levels of copper-zinc superoxide dismutase or glutathione peroxidase 1, which removes H(2)O(2) using glutathione as substrate.	Tetradecanoylphorbol Acetate	13-16	glutathione peroxidase 1	Homo sapiens	209-233
19302816-6	2009	After treatment of these two cell types with phorbol 12-myristate 13-acetate (PMA) for 48 h, cells with reduced Nm23-H1 expression had a higher percentage of 8N ploidy and higher expression of CD41 than K562 cells overexpressing Nm23-H1.	Tetradecanoylphorbol Acetate	45-76	integrin subunit alpha 2b	Homo sapiens	193-197
19302816-6	2009	After treatment of these two cell types with phorbol 12-myristate 13-acetate (PMA) for 48 h, cells with reduced Nm23-H1 expression had a higher percentage of 8N ploidy and higher expression of CD41 than K562 cells overexpressing Nm23-H1.	Tetradecanoylphorbol Acetate	78-81	integrin subunit alpha 2b	Homo sapiens	193-197
19244111-8	2009	Remarkably, up-regulation of both IL-17 expression in the skin and T helper 17 (Th17) cell number in draining lymph nodes after DMBA/TPA treatment was dependent on IFNgamma signaling.	Tetradecanoylphorbol Acetate	133-136	interleukin 17A	Mus musculus	34-39
19244111-9	2009	Depletion of IL-17 not only decreased the DMBA/TPA-induced inflammation and keratinocyte proliferation but also delayed papilloma development.	Tetradecanoylphorbol Acetate	47-50	interleukin 17A	Mus musculus	13-18
19124542-6	2009	In contrast, the phorbol ester PMA (phorbol-12-myristate-13-acetate, a pharmacological mimic of the downstream mediator diacylglycerol in alpha-adrenergic signalling), caused continuous PKD-dependent HDAC5-GFP nuclear efflux and maintained PKD1-mPlum redistribution.	Tetradecanoylphorbol Acetate	31-34	protein kinase D1	Mus musculus	186-189
19164581-4	2009	After exposure of cells to the AP-1 agonist 12-O-tetradecanoylphorbol-13-acetate (TPA), CRTC1 is recruited to AP-1 target gene promoters and associates with c-Jun and c-Fos to activate transcription.	Tetradecanoylphorbol Acetate	44-80	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-35
19164581-4	2009	After exposure of cells to the AP-1 agonist 12-O-tetradecanoylphorbol-13-acetate (TPA), CRTC1 is recruited to AP-1 target gene promoters and associates with c-Jun and c-Fos to activate transcription.	Tetradecanoylphorbol Acetate	44-80	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	110-114
19164581-4	2009	After exposure of cells to the AP-1 agonist 12-O-tetradecanoylphorbol-13-acetate (TPA), CRTC1 is recruited to AP-1 target gene promoters and associates with c-Jun and c-Fos to activate transcription.	Tetradecanoylphorbol Acetate	44-80	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-162
19164581-4	2009	After exposure of cells to the AP-1 agonist 12-O-tetradecanoylphorbol-13-acetate (TPA), CRTC1 is recruited to AP-1 target gene promoters and associates with c-Jun and c-Fos to activate transcription.	Tetradecanoylphorbol Acetate	44-80	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-172
19164581-4	2009	After exposure of cells to the AP-1 agonist 12-O-tetradecanoylphorbol-13-acetate (TPA), CRTC1 is recruited to AP-1 target gene promoters and associates with c-Jun and c-Fos to activate transcription.	Tetradecanoylphorbol Acetate	82-85	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-35
19164581-4	2009	After exposure of cells to the AP-1 agonist 12-O-tetradecanoylphorbol-13-acetate (TPA), CRTC1 is recruited to AP-1 target gene promoters and associates with c-Jun and c-Fos to activate transcription.	Tetradecanoylphorbol Acetate	82-85	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	110-114
19164581-4	2009	After exposure of cells to the AP-1 agonist 12-O-tetradecanoylphorbol-13-acetate (TPA), CRTC1 is recruited to AP-1 target gene promoters and associates with c-Jun and c-Fos to activate transcription.	Tetradecanoylphorbol Acetate	82-85	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-162
19164581-4	2009	After exposure of cells to the AP-1 agonist 12-O-tetradecanoylphorbol-13-acetate (TPA), CRTC1 is recruited to AP-1 target gene promoters and associates with c-Jun and c-Fos to activate transcription.	Tetradecanoylphorbol Acetate	82-85	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-172
19000913-6	2009	Pre-treatment of DAT expressing cells with phorbol-12-myristate-13-acetate, an activator of protein kinase C, attenuated the inhibitory effect of Zn(2+) on uptake in HEK293 cells and increased the stimulatory effect in SK-N-MC cells.	Tetradecanoylphorbol Acetate	43-74	solute carrier family 6 member 3	Homo sapiens	17-20
19118017-4	2009	We confirmed that CXCR2 is expressed by keratinocytes and showed that transformation by oncogenic ras (a hallmark of DMBA initiation) or TPA exposure induced all CXCR2 ligands.	Tetradecanoylphorbol Acetate	137-140	chemokine (C-X-C motif) receptor 2	Mus musculus	18-23
19118017-4	2009	We confirmed that CXCR2 is expressed by keratinocytes and showed that transformation by oncogenic ras (a hallmark of DMBA initiation) or TPA exposure induced all CXCR2 ligands.	Tetradecanoylphorbol Acetate	137-140	chemokine (C-X-C motif) receptor 2	Mus musculus	162-167
19118017-11	2009	The up-regulation of CXCR2 ligands after initiation by oncogenic ras and promotion with TPA in the mouse skin model provides a mechanism to stimulate migration by both autocrine and paracrine pathways and contribute to tumor development.	Tetradecanoylphorbol Acetate	88-91	chemokine (C-X-C motif) receptor 2	Mus musculus	21-26
19358982-8	2009	In contrast, PMA-treated monocytes bypassed caspase 3, 9 pathways and lead to cathepsin B-dependent necrosis.	Tetradecanoylphorbol Acetate	13-16	cathepsin B	Homo sapiens	78-89
19922365-6	2009	Phorbol 12-myristate 13-acetate, a PKC activator, significantly increased wild-type EAAT3 activity.	Tetradecanoylphorbol Acetate	0-31	solute carrier family 1 member 1	Rattus norvegicus	84-89
19056110-6	2009	RESULTS: Approximately 10% of APT-infiltrating T cells secreted IL-17 after phorbol 12-myristate 13-acetate (PMA)/ionomycin stimulation.	Tetradecanoylphorbol Acetate	76-107	interleukin 17A	Homo sapiens	64-69
19056110-6	2009	RESULTS: Approximately 10% of APT-infiltrating T cells secreted IL-17 after phorbol 12-myristate 13-acetate (PMA)/ionomycin stimulation.	Tetradecanoylphorbol Acetate	109-112	interleukin 17A	Homo sapiens	64-69
18952052-2	2008	While screening for compounds that could block the association of HDAC4 with the BTB domain-containing transcriptional repressor Bach2, we discovered that phorbol 12-myristate 13-acetate (PMA) induced the cytoplasmic retention of HDAC4 mutants lacking a nuclear export signal (NES).	Tetradecanoylphorbol Acetate	155-186	BTB domain and CNC homolog 2	Homo sapiens	129-134
18952052-2	2008	While screening for compounds that could block the association of HDAC4 with the BTB domain-containing transcriptional repressor Bach2, we discovered that phorbol 12-myristate 13-acetate (PMA) induced the cytoplasmic retention of HDAC4 mutants lacking a nuclear export signal (NES).	Tetradecanoylphorbol Acetate	188-191	BTB domain and CNC homolog 2	Homo sapiens	129-134
18456322-6	2008	Ba(2+) influx was reduced by 30-40% when cells were treated with either a PKC inhibitor (Go 6983, bisindolylmaleimide) or the PKC activator phorbol-12-myristate-13-acetate.	Tetradecanoylphorbol Acetate	140-171	protein kinase C, alpha	Rattus norvegicus	126-129
18703851-3	2008	While 12-O-tetradecanoyl-phorbol-13 acetate, a protein kinase C activator, increased the expression of annexin A5 mRNA, bisindolylmaleimide, an inhibitor of protein kinase C, suppressed GnRHa-stimulated expression of annexin A5 and LHbeta mRNA.	Tetradecanoylphorbol Acetate	6-43	annexin A5	Mus musculus	103-113
18703851-3	2008	While 12-O-tetradecanoyl-phorbol-13 acetate, a protein kinase C activator, increased the expression of annexin A5 mRNA, bisindolylmaleimide, an inhibitor of protein kinase C, suppressed GnRHa-stimulated expression of annexin A5 and LHbeta mRNA.	Tetradecanoylphorbol Acetate	6-43	annexin A5	Mus musculus	217-227
19048121-3	2008	Here, we explored a pathway by which phorbol 12-myristate 13-acetate (PMA) up-regulates KAI1 transcription in LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	37-68	CD82 molecule	Homo sapiens	88-92
19048121-3	2008	Here, we explored a pathway by which phorbol 12-myristate 13-acetate (PMA) up-regulates KAI1 transcription in LNCaP prostate cancer cells.	Tetradecanoylphorbol Acetate	70-73	CD82 molecule	Homo sapiens	88-92
18927459-9	2008	Combining minocycline with delayed 6-hour tPA decreased plasma MMP-9 levels, reduced infarction, and ameliorated brain hemorrhage.	Tetradecanoylphorbol Acetate	42-45	matrix metallopeptidase 9	Rattus norvegicus	63-68
18703509-4	2008	Overexpression of constitutively active PKD or PKD activation by treatment with phorbol 12-myristate 13-acetate results in phosphorylation of two serine residues (Ser5 and Ser87) in a form of Bit1 that is confined to the cytoplasm and concomitantly increases the apoptotic activity of cytoplasmic Bit1.	Tetradecanoylphorbol Acetate	80-111	protein kinase D1	Homo sapiens	40-43
18703509-4	2008	Overexpression of constitutively active PKD or PKD activation by treatment with phorbol 12-myristate 13-acetate results in phosphorylation of two serine residues (Ser5 and Ser87) in a form of Bit1 that is confined to the cytoplasm and concomitantly increases the apoptotic activity of cytoplasmic Bit1.	Tetradecanoylphorbol Acetate	80-111	protein kinase D1	Homo sapiens	47-50
18922899-8	2008	CD34, considered a marker for both KSCs and skin cancer stem cells, and Rac1, a key gene stimulating KSC self-renewal, were greatly increased in tumors produced by arsenic plus TPA exposure versus TPA alone, and both were elevated in arsenic-treated fetal skin.	Tetradecanoylphorbol Acetate	177-180	Rac family small GTPase 1	Homo sapiens	72-76
18922899-9	2008	Greatly increased numbers of CD34-positive probable cancer stem cells and marked overexpression of RAC1 protein occurred in tumors induced by arsenic plus TPA compared with TPA alone.	Tetradecanoylphorbol Acetate	155-158	Rac family small GTPase 1	Homo sapiens	99-103
18922899-9	2008	Greatly increased numbers of CD34-positive probable cancer stem cells and marked overexpression of RAC1 protein occurred in tumors induced by arsenic plus TPA compared with TPA alone.	Tetradecanoylphorbol Acetate	173-176	Rac family small GTPase 1	Homo sapiens	99-103
18684225-3	2008	Concanavalin A induced expression of IL-2 mRNA and production of IL-2, and the combination of thapsigargin and phorbol myristate acetate induced expression of IL-4 and IL-10 mRNAs and production of IL-4 and IL-10.	Tetradecanoylphorbol Acetate	111-136	interleukin 10	Homo sapiens	168-173
18684225-3	2008	Concanavalin A induced expression of IL-2 mRNA and production of IL-2, and the combination of thapsigargin and phorbol myristate acetate induced expression of IL-4 and IL-10 mRNAs and production of IL-4 and IL-10.	Tetradecanoylphorbol Acetate	111-136	interleukin 10	Homo sapiens	207-212
18499341-2	2008	In this study, we found that CKS reduced 12-O-tetradecanoylphorbol-13-acetate (PMA)-enhanced Matrix metalloproteinases (MMP)-9 and MMP-2 activation in a dose-dependant manner and further inhibited HT-1080 cell invasion and migration.	Tetradecanoylphorbol Acetate	41-77	matrix metallopeptidase 9	Homo sapiens	93-126
18499341-2	2008	In this study, we found that CKS reduced 12-O-tetradecanoylphorbol-13-acetate (PMA)-enhanced Matrix metalloproteinases (MMP)-9 and MMP-2 activation in a dose-dependant manner and further inhibited HT-1080 cell invasion and migration.	Tetradecanoylphorbol Acetate	79-82	matrix metallopeptidase 9	Homo sapiens	93-126
18768832-8	2008	Specific Abs against Rab27a inhibited Ca(2+) and GTP-gamma-S activation and PMA-induced exocytosis of CD66b-enriched tertiary and specific granules in electropermeabilized neutrophils, whereas secretion of CD63-enriched azurophil granules was scarcely affected.	Tetradecanoylphorbol Acetate	76-79	RAB27A, member RAS oncogene family	Homo sapiens	21-27
18511809-3	2008	We dis-covered that CD45 is sequentially cleaved by serine/metalloproteinases and gamma-secretases during activation of human monocytes and granulocytes by fungal stimuli or phorbol 12-myristate 13-acetate but not by other microbial stimuli.	Tetradecanoylphorbol Acetate	174-205	protein tyrosine phosphatase receptor type C	Homo sapiens	20-24
18583709-8	2008	Moreover, silencing of cardiomyocyte Hsp25 allowed phorbol 12-myristate 13-acetate to elicit a significant phosphorylation of PKCdelta, an appreciable association between PKCdelta and PKD, and a vigorous activation of PKD.	Tetradecanoylphorbol Acetate	51-82	protein kinase D1	Homo sapiens	184-187
18583709-8	2008	Moreover, silencing of cardiomyocyte Hsp25 allowed phorbol 12-myristate 13-acetate to elicit a significant phosphorylation of PKCdelta, an appreciable association between PKCdelta and PKD, and a vigorous activation of PKD.	Tetradecanoylphorbol Acetate	51-82	protein kinase D1	Homo sapiens	218-221
18579711-5	2008	Inflammation was induced in the ear skin with five topical applications of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and a significantly increased inflammation was found in TPA-induced K14/VEGF transgenic animals compared with wild-type mice.	Tetradecanoylphorbol Acetate	175-178	vascular endothelial growth factor A	Mus musculus	191-195
18579711-11	2008	In conclusion, the TPA-induced phenotype in K14/VEGF animals displayed several features of psoriasis, including a T(h)17 cytokine profile and a chronic-like progression, and can be used as an in vivo screening model of psoriasis.	Tetradecanoylphorbol Acetate	19-22	vascular endothelial growth factor A	Mus musculus	48-52
18534633-0	2008	Hemin inhibits cyclooxygenase-2 expression through nuclear factor-kappa B activation and ornithine decarboxylase expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin.	Tetradecanoylphorbol Acetate	127-163	ornithine decarboxylase, structural 1	Mus musculus	89-112
18177935-4	2008	By using 12-O-tetradecanoylphorbol-13-acetate (TPA)-differentiated human promyelocytic HL-60 and promonocytic U-937 cells, we discover that polyamines block the expression, secretion and activation of MMP-9.	Tetradecanoylphorbol Acetate	9-45	matrix metallopeptidase 9	Homo sapiens	201-206
18177935-4	2008	By using 12-O-tetradecanoylphorbol-13-acetate (TPA)-differentiated human promyelocytic HL-60 and promonocytic U-937 cells, we discover that polyamines block the expression, secretion and activation of MMP-9.	Tetradecanoylphorbol Acetate	47-50	matrix metallopeptidase 9	Homo sapiens	201-206
18177935-7	2008	In addition, the NF-kappaB inhibitors (pyrrolidinedithiocarbamate, BAY-11-7082 and lactacystin) suppress the TPA-induced MMP-9 enzyme activity.	Tetradecanoylphorbol Acetate	109-112	matrix metallopeptidase 9	Homo sapiens	121-126
18177935-10	2008	Therefore, we suggest that ODC inhibits the TNF-alpha-elevated MMP-9 activation via NF-kappaB as TPA-induced macrophage-like differentiation and this interrupting mechanism may provide a new conceivable resolution why leukemia is poorly differentiated besides atypical growth.	Tetradecanoylphorbol Acetate	97-100	matrix metallopeptidase 9	Homo sapiens	63-68
18501114-2	2008	METHODS: The treatment of synchronized ASM cells from asthmatic rats with PKC-specific agonist phorbol 12-myristate 13-acetate (PMA) and antagonist 2-{1-[3-(amidinothio) propyl]-1Hindol-3-yl}-3-(1-methylindol-3-yl) maleimide methanesulfonate salt (Ro31-8220) was followed by the proliferation assay.	Tetradecanoylphorbol Acetate	95-126	protein kinase C, gamma	Rattus norvegicus	74-77
18516710-1	2008	OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF).	Tetradecanoylphorbol Acetate	119-150	interleukin 18	Homo sapiens	76-90
18516710-1	2008	OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF).	Tetradecanoylphorbol Acetate	119-150	interleukin 18	Homo sapiens	92-97
18516710-1	2008	OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF).	Tetradecanoylphorbol Acetate	152-155	interleukin 18	Homo sapiens	76-90
18516710-1	2008	OBJECTIVE: To determine the effects of triptolide (TP) on the expression of interleukin-18 (IL-18) and its receptor in phorbol 12-myristate 13-acetate (PMA)-stimulated rheumatoid arthritis synovial fibroblasts (RASF).	Tetradecanoylphorbol Acetate	152-155	interleukin 18	Homo sapiens	92-97
18583263-7	2008	RSG inhibited protein synthesis enhancement and increased (3)H-leucine incorporation induced by ET-1 and PMA, and antagonized the effects of ET-1 and PMA in promoting PKC activity and c-fos protein expression in the myocytes.	Tetradecanoylphorbol Acetate	150-153	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	184-189
18295358-3	2008	Reciprocal immunoprecipitations followed by Western blot analysis demonstrated that all PKC isozymes expressed in rat hepatocytes are modified by tyrosine nitration and tyrosine phosphorylation in different ways upon exposure of cells to a direct PKC activator (TPA), or to an extracellular ligand known to activate PKC-dependent pathways (epinephrine).	Tetradecanoylphorbol Acetate	262-265	protein kinase C, alpha	Rattus norvegicus	88-91
18423386-5	2008	Analysis of the Ras-MAPK pathway upon phorbol myristate acetate (PMA) and ionomycin stimulation revealed that PLD2 promoted an early and sustained increase in ERK1/2 phosphorylation in both cell lines.	Tetradecanoylphorbol Acetate	38-63	phospholipase D2	Homo sapiens	110-114
18423386-5	2008	Analysis of the Ras-MAPK pathway upon phorbol myristate acetate (PMA) and ionomycin stimulation revealed that PLD2 promoted an early and sustained increase in ERK1/2 phosphorylation in both cell lines.	Tetradecanoylphorbol Acetate	65-68	phospholipase D2	Homo sapiens	110-114
18390749-6	2008	In addition, inducible expression of KLF4 in the HL60 human acute myeloid leukemia cell line stimulated monocytic differentiation and enhanced 12-O-tetradecanoylphorbol 13-acetate induced macrophage differentiation, but blocked all-trans-retinoic acid induced granulocytic differentiation of HL60 cells.	Tetradecanoylphorbol Acetate	143-179	Kruppel like factor 4	Homo sapiens	37-41
18088599-2	2008	In this study, we examined the inhibitory effect of capillarisin, a bioactive flavonoid of Artemisia capillaries, on phorbol myristate acetate (PMA)-induced MMP-9 expression in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	117-142	matrix metallopeptidase 9	Homo sapiens	157-162
18088599-2	2008	In this study, we examined the inhibitory effect of capillarisin, a bioactive flavonoid of Artemisia capillaries, on phorbol myristate acetate (PMA)-induced MMP-9 expression in MCF-7 human breast carcinoma cells.	Tetradecanoylphorbol Acetate	144-147	matrix metallopeptidase 9	Homo sapiens	157-162
18088599-3	2008	Capillarisin significantly and selectively suppressed PMA-induced MMP-9 expression in MCF-7 and the Matrigel invasion assay showed that capillarisin reduces PMA-induced invasion of MCF-7 cells.	Tetradecanoylphorbol Acetate	54-57	matrix metallopeptidase 9	Homo sapiens	66-71
18088599-4	2008	Capillarisin has been found to suppress PMA-induced MMP-9 expression through inhibition of the NF-kappaB-dependent transcriptional activity of MMP-9 gene via p38 MAPK and JNK signaling pathways.	Tetradecanoylphorbol Acetate	40-43	matrix metallopeptidase 9	Homo sapiens	52-57
18088599-4	2008	Capillarisin has been found to suppress PMA-induced MMP-9 expression through inhibition of the NF-kappaB-dependent transcriptional activity of MMP-9 gene via p38 MAPK and JNK signaling pathways.	Tetradecanoylphorbol Acetate	40-43	matrix metallopeptidase 9	Homo sapiens	143-148
18197699-4	2008	Here we characterize STAT5 tyrosine phosphorylation and its interaction with LMW-PTP during early phorbol-12-myristate-13-acetate-induced megakaryocyte differentiation; these processes show clear dependence on STAT5 threonine phosphorylation.	Tetradecanoylphorbol Acetate	98-129	acid phosphatase 1	Homo sapiens	77-84
18197699-5	2008	Since protein kinase C inhibition prevents phorbol-12-myristate-13-acetate-induced STAT5 threonine phosphorylation and association with LMW-PTP, it follows that these processes depend on protein kinase C activity.	Tetradecanoylphorbol Acetate	43-74	acid phosphatase 1	Homo sapiens	136-143
18172297-8	2008	Experiments using small interfering RNA-mediated knockdown indicate that this activation is mediated by Rap1, which is activated by a TPA-responsive guanine nucleotide exchange factor RasGRP3.	Tetradecanoylphorbol Acetate	134-137	RAS, guanyl releasing protein 3	Mus musculus	184-191
18172297-10	2008	These results imply that two TPA targets, RasGRP3 and PKC, are involved in TPA-induced inflammation through PLC epsilon activation, leading to tumor promotion.	Tetradecanoylphorbol Acetate	29-32	RAS, guanyl releasing protein 3	Mus musculus	42-49
18172297-10	2008	These results imply that two TPA targets, RasGRP3 and PKC, are involved in TPA-induced inflammation through PLC epsilon activation, leading to tumor promotion.	Tetradecanoylphorbol Acetate	75-78	RAS, guanyl releasing protein 3	Mus musculus	42-49
18692180-3	2008	Inhibition of PKC pathway, by chemical inhibitors or after PMA treatment, abolishes both IL-10 and TNF-alpha production.	Tetradecanoylphorbol Acetate	59-62	interleukin 10	Homo sapiens	89-94
18714538-4	2008	RESULTS: SCF enhanced human basophil histamine release elicited by some, but not all, secretagogues; degranulation in response to IgE- or FcepsilonRI-mediated stimulation and 12-o-tetradecanoyl-phorbol-13-acetate (TPA) was enhanced by SCF.	Tetradecanoylphorbol Acetate	214-217	KIT ligand	Homo sapiens	9-12
17681645-9	2008	The increase in intracellular Ca2+ by ionophore A23187 showed no effect, whereas PKC activation by phorbol 12-myristate 13-acetate (TPA) potently stimulated BDNF levels in the cells.	Tetradecanoylphorbol Acetate	99-130	brain-derived neurotrophic factor	Rattus norvegicus	157-161
17681645-9	2008	The increase in intracellular Ca2+ by ionophore A23187 showed no effect, whereas PKC activation by phorbol 12-myristate 13-acetate (TPA) potently stimulated BDNF levels in the cells.	Tetradecanoylphorbol Acetate	132-135	brain-derived neurotrophic factor	Rattus norvegicus	157-161
17681645-10	2008	The methoxamine-stimulated BDNF synthesis was inhibited by desensitizing pretreatment with TPA, indicating that the alpha1-stimulation was mediated via PKC activation.	Tetradecanoylphorbol Acetate	91-94	brain-derived neurotrophic factor	Rattus norvegicus	27-31
18025046-2	2008	It is known that phorbol 12-myristate 13-acetate (PMA)-activated signal transduction pathway is thought to be involved in the oncogene action in NSCLC and enzymatic activation of cPLA2.	Tetradecanoylphorbol Acetate	17-48	phospholipase A2 group IVA	Homo sapiens	179-184
18025046-2	2008	It is known that phorbol 12-myristate 13-acetate (PMA)-activated signal transduction pathway is thought to be involved in the oncogene action in NSCLC and enzymatic activation of cPLA2.	Tetradecanoylphorbol Acetate	50-53	phospholipase A2 group IVA	Homo sapiens	179-184
18023089-6	2007	Intracellular cytokine analysis for anti-inflammatory cytokine interleukin-10 (IL-10) was performed by in vitro stimulation with phorbol-myristate-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	129-154	interleukin 10	Homo sapiens	63-77
18023089-6	2007	Intracellular cytokine analysis for anti-inflammatory cytokine interleukin-10 (IL-10) was performed by in vitro stimulation with phorbol-myristate-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	129-154	interleukin 10	Homo sapiens	79-84
18023089-6	2007	Intracellular cytokine analysis for anti-inflammatory cytokine interleukin-10 (IL-10) was performed by in vitro stimulation with phorbol-myristate-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	156-159	interleukin 10	Homo sapiens	63-77
18023089-6	2007	Intracellular cytokine analysis for anti-inflammatory cytokine interleukin-10 (IL-10) was performed by in vitro stimulation with phorbol-myristate-acetate (PMA) and ionomycin.	Tetradecanoylphorbol Acetate	156-159	interleukin 10	Homo sapiens	79-84
18023089-11	2007	Interestingly, approximately 4% of mucosal NKR(+) T cells expressing IL-10 were detected by in vitro stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	118-121	interleukin 10	Homo sapiens	69-74
17581112-8	2007	CONCLUSIONS: The overexpression of TrxR1 inhibits migration of HEK-293 cells stimulated with PMA and DPhT.	Tetradecanoylphorbol Acetate	93-96	thioredoxin reductase 1	Homo sapiens	35-40
17761425-4	2007	MMP-9 effect was enhanced by phorbol 12-mysistrate-13-acetate (PMA), an alpha-secretase activator and inhibited by EDTA or SB-3CT, an MMP-9 inhibitor.	Tetradecanoylphorbol Acetate	63-66	matrix metallopeptidase 9	Homo sapiens	0-5
18041647-9	2007	K562/7 cells treated with phorbol 12-myristate 13-acetate (PMA), showed a great shift in ploidy towards high ploidy classes (&gt; or =8N) accompanied with an increase in the expression of the maturation marker CD42b.	Tetradecanoylphorbol Acetate	26-57	glycoprotein Ib platelet subunit alpha	Homo sapiens	210-215
18041647-9	2007	K562/7 cells treated with phorbol 12-myristate 13-acetate (PMA), showed a great shift in ploidy towards high ploidy classes (&gt; or =8N) accompanied with an increase in the expression of the maturation marker CD42b.	Tetradecanoylphorbol Acetate	59-62	glycoprotein Ib platelet subunit alpha	Homo sapiens	210-215
17407154-0	2007	The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells.	Tetradecanoylphorbol Acetate	127-130	CD9 molecule	Homo sapiens	59-62
17407154-0	2007	The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells.	Tetradecanoylphorbol Acetate	127-130	CD81 molecule	Homo sapiens	64-68
17407154-4	2007	TPA increased targeting of CD81 and CD9P-1 into exosomes but strongly reduced the localization of the TfR in these vesicles.	Tetradecanoylphorbol Acetate	0-3	CD81 molecule	Homo sapiens	27-31
17845534-4	2007	PKC-alpha and PKC-zeta were located predominantly in the cytosol and were redistributed to the membrane by the PKC agonist, phorbol 12-myristate 13-acetate (PMA), while PKC-delta and PKC-epsilon were highly membrane-bound and did not undergo translocation by PMA.	Tetradecanoylphorbol Acetate	124-155	protein kinase C, alpha	Rattus norvegicus	0-9
17845534-4	2007	PKC-alpha and PKC-zeta were located predominantly in the cytosol and were redistributed to the membrane by the PKC agonist, phorbol 12-myristate 13-acetate (PMA), while PKC-delta and PKC-epsilon were highly membrane-bound and did not undergo translocation by PMA.	Tetradecanoylphorbol Acetate	124-155	protein kinase C, alpha	Rattus norvegicus	0-3
17845534-4	2007	PKC-alpha and PKC-zeta were located predominantly in the cytosol and were redistributed to the membrane by the PKC agonist, phorbol 12-myristate 13-acetate (PMA), while PKC-delta and PKC-epsilon were highly membrane-bound and did not undergo translocation by PMA.	Tetradecanoylphorbol Acetate	157-160	protein kinase C, alpha	Rattus norvegicus	0-9
17845534-4	2007	PKC-alpha and PKC-zeta were located predominantly in the cytosol and were redistributed to the membrane by the PKC agonist, phorbol 12-myristate 13-acetate (PMA), while PKC-delta and PKC-epsilon were highly membrane-bound and did not undergo translocation by PMA.	Tetradecanoylphorbol Acetate	157-160	protein kinase C, alpha	Rattus norvegicus	0-3
17845534-4	2007	PKC-alpha and PKC-zeta were located predominantly in the cytosol and were redistributed to the membrane by the PKC agonist, phorbol 12-myristate 13-acetate (PMA), while PKC-delta and PKC-epsilon were highly membrane-bound and did not undergo translocation by PMA.	Tetradecanoylphorbol Acetate	259-262	protein kinase C, alpha	Rattus norvegicus	0-9
17845534-4	2007	PKC-alpha and PKC-zeta were located predominantly in the cytosol and were redistributed to the membrane by the PKC agonist, phorbol 12-myristate 13-acetate (PMA), while PKC-delta and PKC-epsilon were highly membrane-bound and did not undergo translocation by PMA.	Tetradecanoylphorbol Acetate	259-262	protein kinase C, alpha	Rattus norvegicus	0-3
17646168-7	2007	The protein H-Ras and activated Ras-GTP significantly decreased in TPA-induced skin tissues of DCR-fed mice but not exercised mice.	Tetradecanoylphorbol Acetate	67-70	Harvey rat sarcoma virus oncogene	Mus musculus	12-17
17908462-12	2007	PKC down-regulation by PMA pretreatment or PKC inhibition by Ro31-8220 pre-incubation abolished the effect of 5% CSE on PASMCs proliferation.	Tetradecanoylphorbol Acetate	23-26	protein kinase C, alpha	Rattus norvegicus	0-3
17603013-4	2007	Heat shock and other cellular stresses including H2O2, 12-O-tetradecanoylphorbol 13-acetate (TPA), lipopolysaccharide (LPS), and UV enhance TC1 transcription in HeLa, KATO-III, HEK293T, and HK cells.	Tetradecanoylphorbol Acetate	55-91	transcriptional and immune response regulator	Homo sapiens	140-143
17603013-4	2007	Heat shock and other cellular stresses including H2O2, 12-O-tetradecanoylphorbol 13-acetate (TPA), lipopolysaccharide (LPS), and UV enhance TC1 transcription in HeLa, KATO-III, HEK293T, and HK cells.	Tetradecanoylphorbol Acetate	93-96	transcriptional and immune response regulator	Homo sapiens	140-143
17429438-4	2007	Epithelial carcinoma HeLa cells, which exclusively express Nox2, showed dramatically increased activation of NADPH oxidase by phorbol 12-myristate 13-acetate after S100A8/A9 gene transfection.	Tetradecanoylphorbol Acetate	126-157	cytochrome b-245 beta chain	Homo sapiens	59-63
17286201-6	2007	The level of PMA-induced p21WAF1/Cip1 protein expression was lower in NB4 cells overexpressing wild type protein kinase C zeta (PKC zeta) compared to those transfected with empty vector or with kinase inactive PKC zeta.	Tetradecanoylphorbol Acetate	13-16	protein kinase C zeta	Homo sapiens	105-126
17286201-6	2007	The level of PMA-induced p21WAF1/Cip1 protein expression was lower in NB4 cells overexpressing wild type protein kinase C zeta (PKC zeta) compared to those transfected with empty vector or with kinase inactive PKC zeta.	Tetradecanoylphorbol Acetate	13-16	protein kinase C zeta	Homo sapiens	128-136
17286201-6	2007	The level of PMA-induced p21WAF1/Cip1 protein expression was lower in NB4 cells overexpressing wild type protein kinase C zeta (PKC zeta) compared to those transfected with empty vector or with kinase inactive PKC zeta.	Tetradecanoylphorbol Acetate	13-16	protein kinase C zeta	Homo sapiens	210-218
17286201-8	2007	We demonstrate that PI 3-K signaling pathway suppresses PMA-induced expression of p21WAF1/Cip1 in human leukemia cells, and that this effect is partly mediated by PKC zeta.	Tetradecanoylphorbol Acetate	56-59	protein kinase C zeta	Homo sapiens	163-171
17603158-8	2007	In addition, AGP significantly suppressed superoxide generation from neutrophils that has been treated with fMLP or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	116-147	orosomucoid 1	Rattus norvegicus	13-16
17908428-0	2007	[The effect of PKC phosphorylation sites mutation in JWA coding region on TPA-induced MCF-7 cell differentiation].	Tetradecanoylphorbol Acetate	74-77	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	53-56
17908428-1	2007	OBJECTIVE: To investigate the effect of PKC phosphorylation sites mutation in JWA coding region on TPA-induced MCF-7 cell differentiation.	Tetradecanoylphorbol Acetate	99-102	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	78-81
17382927-4	2007	Phorbol-12-myristate-13-acetate (a PKC activator), also abolished this t-BHP-induced reduction in EAAT3 activity, whereas staurosporine (a PKC inhibitor), significantly decreased EAAT3 activity.	Tetradecanoylphorbol Acetate	0-31	solute carrier family 1 member 1	Rattus norvegicus	98-103
17332158-5	2007	In contrast, phorbol 12-myristate 13-acetate (PMA) treatment induced MMP-9 activity in turkey chondrocytes but not in those of chicken.	Tetradecanoylphorbol Acetate	13-44	LOW QUALITY PROTEIN: matrix metalloproteinase-9	Meleagris gallopavo	69-74
17332158-5	2007	In contrast, phorbol 12-myristate 13-acetate (PMA) treatment induced MMP-9 activity in turkey chondrocytes but not in those of chicken.	Tetradecanoylphorbol Acetate	46-49	LOW QUALITY PROTEIN: matrix metalloproteinase-9	Meleagris gallopavo	69-74
17332158-9	2007	Finally, the combined treatments of RA or PMA with thiram induced MMP-9 activity in turkey but not in chicken chondrocytes.	Tetradecanoylphorbol Acetate	42-45	LOW QUALITY PROTEIN: matrix metalloproteinase-9	Meleagris gallopavo	66-71
17336041-3	2007	Data in this study show that JWA, a newly identified novel microtubule-associated protein (MAP) was essential for the rearrangement of F-actin cytoskeleton and activation of MAPK cascades induced by arsenic trioxide (As2O3) and phorbol ester (PMA).	Tetradecanoylphorbol Acetate	243-246	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	29-32
17314023-1	2007	Long-term culture of phorbol ester (TPA)-differentiated and growth-arrested human U937 leukemia cells was associated with expression of c-jun transcription factors and vimentin intermediate filaments until the cells entered a retrodifferentiation program.	Tetradecanoylphorbol Acetate	36-39	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-141
17674818-4	2007	The induction of inflammation in skin mediated by TPA is believed to be governed by cyclooxygenase (COX), lipoxygenase and ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	50-53	ornithine decarboxylase, structural 1	Mus musculus	123-146
17674818-4	2007	The induction of inflammation in skin mediated by TPA is believed to be governed by cyclooxygenase (COX), lipoxygenase and ornithine decarboxylase (ODC).	Tetradecanoylphorbol Acetate	50-53	ornithine decarboxylase, structural 1	Mus musculus	148-151
17674818-8	2007	TPA treatment also enhanced ODC activity and [3H] thymidine incorporation into cutaneous DNA.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	28-31
17255372-7	2007	Treatment of cardiac fibroblasts with ANG II and TPA resulted in increased expression of DOC-2.	Tetradecanoylphorbol Acetate	49-52	DAB adaptor protein 2	Rattus norvegicus	89-94
17383980-1	2007	Bach2 is a member of the BTB-basic region leucine zipper factor family and represses transcription activity directed by the TPA response element, the Maf recognition element (MARE) and the antioxidant-responsive element.	Tetradecanoylphorbol Acetate	124-127	BTB domain and CNC homolog 2	Homo sapiens	0-5
17430547-6	2007	Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4(+) T cells was inversely correlated with serum CRI and directly correlated with spleen size.	Tetradecanoylphorbol Acetate	11-36	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	122-128
17430547-6	2007	Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4(+) T cells was inversely correlated with serum CRI and directly correlated with spleen size.	Tetradecanoylphorbol Acetate	11-36	CD4 antigen	Mus musculus	140-143
17430547-6	2007	Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4(+) T cells was inversely correlated with serum CRI and directly correlated with spleen size.	Tetradecanoylphorbol Acetate	38-41	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	122-128
17430547-6	2007	Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4(+) T cells was inversely correlated with serum CRI and directly correlated with spleen size.	Tetradecanoylphorbol Acetate	38-41	CD4 antigen	Mus musculus	140-143
17481561-1	2007	Phorbol-12-myristate-13-acetate (PMA) induces megakaryocytopoeisis in human erythroleukemia (HEL) cells which is characterized by the increase in cell size, increase in nuclear polyploidization and expression of megakaryocyte marker, CD41.	Tetradecanoylphorbol Acetate	0-31	integrin subunit alpha 2b	Homo sapiens	234-238
17481561-1	2007	Phorbol-12-myristate-13-acetate (PMA) induces megakaryocytopoeisis in human erythroleukemia (HEL) cells which is characterized by the increase in cell size, increase in nuclear polyploidization and expression of megakaryocyte marker, CD41.	Tetradecanoylphorbol Acetate	33-36	integrin subunit alpha 2b	Homo sapiens	234-238
17151144-6	2007	The inhibitor sensitivity profile and the finding that PMA-induced inhibition was calcium independent suggested a potential role for PKC-delta.	Tetradecanoylphorbol Acetate	55-58	protein kinase C, delta	Mus musculus	133-142
17151144-7	2007	Indeed, the PKC-delta-selective inhibitor rottlerin significantly blocked PMA-induced inhibition of Slc26a6 activity.	Tetradecanoylphorbol Acetate	74-77	protein kinase C, delta	Mus musculus	12-21
17373964-2	2007	The objective was to examine the effects of activation by Phorbol 12-myristate 13-acetate (PMA) or lipopolysaccharide (LPS) and insulin on the expression of GLUT isoforms in all subpopulations of WBC.	Tetradecanoylphorbol Acetate	58-89	solute carrier family 2 member 1	Homo sapiens	157-161
17373964-2	2007	The objective was to examine the effects of activation by Phorbol 12-myristate 13-acetate (PMA) or lipopolysaccharide (LPS) and insulin on the expression of GLUT isoforms in all subpopulations of WBC.	Tetradecanoylphorbol Acetate	91-94	solute carrier family 2 member 1	Homo sapiens	157-161
17227770-4	2007	TPA effect was also prevented by antisense inhibition of protein kinase C (PKC)-zeta and by the expression of a dominant-negative PKC-zeta mutant cDNA in HEK293 cells.	Tetradecanoylphorbol Acetate	0-3	protein kinase C zeta	Homo sapiens	57-84
17227770-4	2007	TPA effect was also prevented by antisense inhibition of protein kinase C (PKC)-zeta and by the expression of a dominant-negative PKC-zeta mutant cDNA in HEK293 cells.	Tetradecanoylphorbol Acetate	0-3	protein kinase C zeta	Homo sapiens	130-138
17227770-5	2007	Similar to long term TPA treatment, overexpression of wild-type PKC-zeta increased cellular content and phosphorylation of WT-PED/PEA-15 and PED(S104G) but not of PED(S116G).	Tetradecanoylphorbol Acetate	21-24	protein kinase C zeta	Homo sapiens	64-72
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	95-98	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-9
17215518-1	2007	The c-Jun/Sp1 interaction is essential for growth factor- and phorbol 12-myristate 13-acetate (PMA)-induced genes expression, including human 12(S)-lipoxygenase, keratin 16, cytosolic phospholipase A2, p21(WAF1/CIP1), and neuronal nicotinic acetylcholine receptor beta4.	Tetradecanoylphorbol Acetate	95-98	phospholipase A2 group IVA	Homo sapiens	174-200
17215518-2	2007	Here, we examined the mechanism underlying the PMA-induced regulation on the interaction between c-Jun and Sp1.	Tetradecanoylphorbol Acetate	47-50	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	97-102
17215518-3	2007	We found that treatment of cells with PMA induced a dephosphorylation at the C terminus of c-Jun at Ser-243 and a concomitant inhibition of PP2B by using PP2B small interfering RNA, resulting in reduction of PMA-induced gene expression as well as the c-Jun/Sp1 interaction.	Tetradecanoylphorbol Acetate	38-41	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-96
17215518-3	2007	We found that treatment of cells with PMA induced a dephosphorylation at the C terminus of c-Jun at Ser-243 and a concomitant inhibition of PP2B by using PP2B small interfering RNA, resulting in reduction of PMA-induced gene expression as well as the c-Jun/Sp1 interaction.	Tetradecanoylphorbol Acetate	38-41	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	251-256
17215518-4	2007	The c-Jun mutant TAM-67-3A, which contains three substitute alanines at Thr-231, Ser-243, and Ser-249 compared with TAM-67, binds more efficaciously with Sp1 and is about twice as efficacious as TAM-67 in inhibiting the PMA-induced activation of the 12(S)-lipoxygenase promoter.	Tetradecanoylphorbol Acetate	220-223	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-9
17334233-0	2007	PMA-induced up-regulation of MMP-9 is regulated by a PKCalpha-NF-kappaB cascade in human lung epithelial cells.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	29-34
17097684-6	2007	The mRNA expression level of hMYADM significantly increased in acute promyelocytic leukemia HL-60 and chronic myelogenous leukemia K562 cell line after phorbol myristate acetate (PMA)-induced differentiation.	Tetradecanoylphorbol Acetate	152-177	myeloid associated differentiation marker	Homo sapiens	29-35
17097684-6	2007	The mRNA expression level of hMYADM significantly increased in acute promyelocytic leukemia HL-60 and chronic myelogenous leukemia K562 cell line after phorbol myristate acetate (PMA)-induced differentiation.	Tetradecanoylphorbol Acetate	179-182	myeloid associated differentiation marker	Homo sapiens	29-35
17200207-3	2007	Gene clustering revealed a robust eightfold increase in matrix metalloproteinase (MMP)-9 expression in surgically resected human invasive PAs and in the (nonfunctioning) HP75 human pituitary tumor-derived cell line treated with phorbol-12-myristate-13-acetate; these results were confirmed by real-time polymerase chain reaction, gelatin zymography, reverse transcriptase-polymerase chain reaction, Western blot, immunohistochemistry, and Northern blot analyses.	Tetradecanoylphorbol Acetate	228-259	matrix metallopeptidase 9	Homo sapiens	56-88
17200207-5	2007	In a transmembrane invasion assay, phorbol-12-myristate-13-acetate (100 nmol/L) increased the number of invaded HP75 cells, a process that was attenuated by PKC inhibitors, MMP-9 antibody, PKC-alpha siRNA, or PKC-delta siRNA.	Tetradecanoylphorbol Acetate	35-66	matrix metallopeptidase 9	Homo sapiens	173-178
17404058-3	2007	Treatment of MCF10A cells with TPA induced the upregulation of COX-2 and MMP-9, and this was attenuated by jaceosidin treatment.	Tetradecanoylphorbol Acetate	31-34	matrix metallopeptidase 9	Homo sapiens	73-78
17404058-6	2007	These results suggest that jaceosidin inhibits the TPA-induced upregulation of COX-2 and MMP-9 by blocking ERK-1 and -2 phosphorylation in human breast epithelial cells, which may be indicative of its chemopreventive potential.	Tetradecanoylphorbol Acetate	51-54	matrix metallopeptidase 9	Homo sapiens	89-94
17160480-1	2007	Emodin inhibited expression of both transforming growth factor beta1 (TGFbeta1)- and phorbol ester (PMA)-induced tissue inhibitors of metalloproteinase-1 (TIMP-1) in an immortalized rat hepatic stellate cell line, HSC-T6, by Western blot and reverse transcription polymerase chain reaction.	Tetradecanoylphorbol Acetate	100-103	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	113-153
17160480-1	2007	Emodin inhibited expression of both transforming growth factor beta1 (TGFbeta1)- and phorbol ester (PMA)-induced tissue inhibitors of metalloproteinase-1 (TIMP-1) in an immortalized rat hepatic stellate cell line, HSC-T6, by Western blot and reverse transcription polymerase chain reaction.	Tetradecanoylphorbol Acetate	100-103	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	155-161
16924416-11	2007	Stimulation of heart with the PKC-activator tetradecanoylphorbol-13-acetate (TPA) lead to a comparable phosphorylation, suggesting that ischemia leads to autophosphorylation of PKC.	Tetradecanoylphorbol Acetate	77-80	protein kinase C, gamma	Rattus norvegicus	30-33
16924416-11	2007	Stimulation of heart with the PKC-activator tetradecanoylphorbol-13-acetate (TPA) lead to a comparable phosphorylation, suggesting that ischemia leads to autophosphorylation of PKC.	Tetradecanoylphorbol Acetate	77-80	protein kinase C, gamma	Rattus norvegicus	177-180
17512973-4	2007	Accordingly, VEGF-induced fibrinolysis correlated with an increase in the expression of tPA and of some MMPs, such as MT2-MMP and was completely blocked by a neutralizing antibody against tPA.	Tetradecanoylphorbol Acetate	188-191	matrix metallopeptidase 15	Homo sapiens	104-108
17512973-4	2007	Accordingly, VEGF-induced fibrinolysis correlated with an increase in the expression of tPA and of some MMPs, such as MT2-MMP and was completely blocked by a neutralizing antibody against tPA.	Tetradecanoylphorbol Acetate	188-191	matrix metallopeptidase 15	Homo sapiens	118-125
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	Tetradecanoylphorbol Acetate	97-100	granulin	Mus musculus	112-116
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	Tetradecanoylphorbol Acetate	97-100	granulin	Mus musculus	182-186
16959900-12	2006	In addition, the effects associated with PMA were reversed with exposure to a myristoylated PKC-zeta pseudosubstrate.	Tetradecanoylphorbol Acetate	41-44	protein kinase C zeta	Homo sapiens	92-100
17082637-3	2006	In this study, we report that TNF-alpha stimulates the expression of the FRA-1 protooncogene in human pulmonary epithelial cells using c-Jun, acting via a 12-O-tetradecanoylphorbol-13 acetate response element located at -318.	Tetradecanoylphorbol Acetate	155-191	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	135-140
16949567-1	2006	The extracellular serine protease, plasmin, is activated from its precursor, plasminogen (Plg), by the urokinase-type and tissue-type Plg activators (uPA and tPA respectively).	Tetradecanoylphorbol Acetate	158-161	complement component 1, s subcomponent 1	Mus musculus	18-33
17048122-3	2006	The cytomegalovirus long terminal repeat (CMV-LTR) has a TPA response element (TRE) as a binding site for activator protein 1 (AP-1), which is induced by oxidative stress.	Tetradecanoylphorbol Acetate	57-60	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-125
17048122-3	2006	The cytomegalovirus long terminal repeat (CMV-LTR) has a TPA response element (TRE) as a binding site for activator protein 1 (AP-1), which is induced by oxidative stress.	Tetradecanoylphorbol Acetate	57-60	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	127-131
16934760-0	2006	TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-48
16984259-6	2006	In culture MMP-21 was upregulated by phorbol myristate acetate in THP-1 cells and by retinoic acid (RA) in U937 cells, and downregulated by transforming growth factor beta 1 (TGF-beta1) in HEL 299 as assessed by Taqman quantitative polymerase chain reaction (PCR).	Tetradecanoylphorbol Acetate	37-62	matrix metallopeptidase 21	Homo sapiens	11-17
16940435-4	2006	After 1 h, TPA increased total c-jun mRNA by 10.5-fold.	Tetradecanoylphorbol Acetate	11-14	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-36
16890203-2	2006	Topical double TPA treatment induced the various inflammatory changes including the epidermal thickness, elevated the PCNA-labeling index, the edema formation, and increased production of hydrogen peroxide (H2O2) in wild type mice (WT).	Tetradecanoylphorbol Acetate	15-18	proliferating cell nuclear antigen	Mus musculus	118-122
16478662-2	2006	It has also been documented for the receptor-like protein tyrosine phosphatase PTP-LAR, induced by treating cells with the tumor promoter TPA or the calcium ionophor A23187.	Tetradecanoylphorbol Acetate	138-141	protein tyrosine phosphatase, receptor type, S	Mus musculus	79-82
16478662-5	2006	In contrast to TPA-induced shedding of PTP-LAR, EGFR-mediated cleavage did not require PKC-activity.	Tetradecanoylphorbol Acetate	15-18	protein tyrosine phosphatase, receptor type, S	Mus musculus	39-42
16846840-10	2006	Our data suggest that one of the mechanisms by which HIV-1 gp120 up-regulates the MOR in TPA-differentiated HL-60 cells is through autocrine/paracrine actions of TNF-alpha via the TNFR-II receptor.	Tetradecanoylphorbol Acetate	89-92	TNF receptor superfamily member 1B	Homo sapiens	180-187
16675540-5	2006	Treatments with hCG, forskolin, or phorbol 12 myristate 13-acetate stimulated Runx1 mRNA expression.	Tetradecanoylphorbol Acetate	35-66	RUNX family transcription factor 1	Rattus norvegicus	78-83
16953115-3	2006	Hsp70 overexpression in human monocytic cell line U937 was found to increase PMA-induced MMP-9 expression and enhance cell motility.	Tetradecanoylphorbol Acetate	77-80	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
16953115-3	2006	Hsp70 overexpression in human monocytic cell line U937 was found to increase PMA-induced MMP-9 expression and enhance cell motility.	Tetradecanoylphorbol Acetate	77-80	matrix metallopeptidase 9	Homo sapiens	89-94
16613839-3	2006	A malignant skin keratinocyte cell line (308), which carries a H-ras mutation at codon 61, showed elevated p53 levels, increased caspase 3 activity and enhanced apoptosis after TPA treatment.	Tetradecanoylphorbol Acetate	177-180	caspase 3	Mus musculus	129-138
16474181-6	2006	Resveratrol blunted TPA-induced phosphorylation of p65 and its interaction with CBP/p300, rendering NF-kappaB transcriptionally inactive.	Tetradecanoylphorbol Acetate	20-23	CREB binding protein	Mus musculus	80-88
16636047-3	2006	A comparative two-dimensional gel proteomic analysis of empty vector- and p35-transfected cells after 12 h of exposure to 20 nm TPA, followed by mass spectrometry analysis, identified 38 differentially expressed proteins.	Tetradecanoylphorbol Acetate	128-131	interleukin 12A	Homo sapiens	74-77
16597486-9	2006	PMA induced ERK3 phosphorylation that was companied by an increase in ERK3/MAP2 association and MAP2 phosphorylation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 6	Rattus norvegicus	12-16
16597486-9	2006	PMA induced ERK3 phosphorylation that was companied by an increase in ERK3/MAP2 association and MAP2 phosphorylation.	Tetradecanoylphorbol Acetate	0-3	mitogen-activated protein kinase 6	Rattus norvegicus	70-74
16740713-2	2006	In the present study, we show that pharmacologic inhibition of PARP-1 with 3,4-dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) results in a strong delay in tumor formation and in a dramatic reduction in tumor size and multiplicity during 7,12-dimethylbenz(a)anthracene plus 12-O-tetradecanoylphorbol-13-acetate-induced skin carcinogenesis.	Tetradecanoylphorbol Acetate	290-326	poly (ADP-ribose) polymerase family, member 1	Mus musculus	63-69
16753836-3	2006	EC-SOD also inhibited the induction of HB-EGF by 12-O-tetradecanoylphorbol-13-acetate (TPA) in RASMC by 60%.	Tetradecanoylphorbol Acetate	49-85	superoxide dismutase 3	Rattus norvegicus	0-6
16753836-3	2006	EC-SOD also inhibited the induction of HB-EGF by 12-O-tetradecanoylphorbol-13-acetate (TPA) in RASMC by 60%.	Tetradecanoylphorbol Acetate	87-90	superoxide dismutase 3	Rattus norvegicus	0-6
16753836-4	2006	Both H2O2 and TPA increased intracellular ROS levels, and EC-SOD inhibited ROS generation only for the case of H2O2 but not TPA.	Tetradecanoylphorbol Acetate	124-127	superoxide dismutase 3	Rattus norvegicus	58-64
16738939-7	2006	Finally, we demonstrate that the Japanese flounder CSF3 gene is at least involved in immunity based on its basal expression in immune-related tissues and its upregulation in kidney and peripheral blood leukocytes after in vitro stimulation with lipopolysaccharide and a combination of concanavalin A/phorbol myristate acetate.	Tetradecanoylphorbol Acetate	300-325	colony stimulating factor 3	Gallus gallus	51-55
16468075-5	2006	Pre-treatment of phorbol-12-myristate-13-acetate (TPA), a PKC activator, decreased ATRA-mediated differentiation, companied with the down-regulation of JWA expression.	Tetradecanoylphorbol Acetate	17-48	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	152-155
16468075-5	2006	Pre-treatment of phorbol-12-myristate-13-acetate (TPA), a PKC activator, decreased ATRA-mediated differentiation, companied with the down-regulation of JWA expression.	Tetradecanoylphorbol Acetate	50-53	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	152-155
16516851-4	2006	The IL-18 production by monocytes stimulated without or with LPS or A23187+PMA for 1day was measured by ELISA.	Tetradecanoylphorbol Acetate	75-78	interleukin 18	Homo sapiens	4-9
16565508-4	2006	Taps represents a potential AP-1 target gene because TPA-induced expression in epidermal keratinocytes critically depends on c-Fos, and co-treatment with dexamethasone, a potent inhibitor of AP-1-mediated gene regulation, resulted in impaired activation of Taps expression.	Tetradecanoylphorbol Acetate	53-56	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	125-130
16430862-5	2006	Our results showed that JWA was not only regulated by ATRA but also by several other differentiation inducers such as phorbol-12-myristate-13-acetate (TPA), arabinoside (Ara-C), and hemin, involved in the mechanisms of differentiation along different lineages of myeloid leukemia cells arrested at different stages of development.	Tetradecanoylphorbol Acetate	118-149	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	24-27
16430862-5	2006	Our results showed that JWA was not only regulated by ATRA but also by several other differentiation inducers such as phorbol-12-myristate-13-acetate (TPA), arabinoside (Ara-C), and hemin, involved in the mechanisms of differentiation along different lineages of myeloid leukemia cells arrested at different stages of development.	Tetradecanoylphorbol Acetate	151-154	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	24-27
16332726-0	2006	Stimulation of CEACAM1 expression by 12-O-tetradecanoylphorbol-13-acetate (TPA) and calcium ionophore A23187 in endometrial carcinoma cells.	Tetradecanoylphorbol Acetate	37-73	CEA cell adhesion molecule 1	Homo sapiens	15-22
16332726-0	2006	Stimulation of CEACAM1 expression by 12-O-tetradecanoylphorbol-13-acetate (TPA) and calcium ionophore A23187 in endometrial carcinoma cells.	Tetradecanoylphorbol Acetate	75-78	CEA cell adhesion molecule 1	Homo sapiens	15-22
16332726-4	2006	No induction of CEACAM1 expression was observed in Hec1B endometrial adenocarcinoma cells in response to hormones and cytokines whereas treatment with TPA and calcium ionophore A23187 resulted in the strong expression of endogenous CEACAM1 on the mRNA and protein levels.	Tetradecanoylphorbol Acetate	151-154	CEA cell adhesion molecule 1	Homo sapiens	232-239
16428084-7	2006	However, phosphorylated STAT4 gradually declined within 24 h. Histamine increased the phosphorylation of STAT4 at lower concentrations (10(-6) to 10(-9) M), and had no effect at higher concentrations (10(-4) and 10(-5) M) after the cells were stimulated with PMA + ionomycin.	Tetradecanoylphorbol Acetate	259-262	signal transducer and activator of transcription 4	Homo sapiens	105-110
16476973-7	2006	Some of the important genes that were overexpressed during the S phase of the cell cycle compared with the G0/1 phase of TPA-induced BCBL-1 cells are v-myb myeloblastosis (MYBL2), protein kinase-membrane associated tyrosine/threonine 1 (PKMYT1), ribonucleotide reductase M1 polypeptide (RRM1) and peroxisome proliferator-activated receptors delta (PPARD).	Tetradecanoylphorbol Acetate	121-124	peroxisome proliferator activated receptor delta	Homo sapiens	348-353
16293641-5	2006	The E2-induced recruitment of c-Fos to a 12-O-tetradecanoylphorbol-13-acetate response element site in the PR promoter was significantly reduced in the presence of ERbeta, whereas only a slight reduction in the recruitment of c-Fos to the pS2 promoter was observed.	Tetradecanoylphorbol Acetate	41-77	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-35
16478997-2	2006	We now show that Sp1 that recruited HDAC1 to the Sp1/cJun complex was constitutively acetylated when cells were exposed to phorbol 12-myristate 13-acetate (PMA) (3 h).	Tetradecanoylphorbol Acetate	123-154	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	53-57
16478997-2	2006	We now show that Sp1 that recruited HDAC1 to the Sp1/cJun complex was constitutively acetylated when cells were exposed to phorbol 12-myristate 13-acetate (PMA) (3 h).	Tetradecanoylphorbol Acetate	156-159	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	53-57
16332693-2	2006	Intercellular adhesion molecule-1 (ICAM-1), an adhesion receptor that mediates inflammatory and immune responses, undergoes shedding in the presence of inflammatory mediators and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	179-210	intercellular adhesion molecule 1	Homo sapiens	0-33
16332693-2	2006	Intercellular adhesion molecule-1 (ICAM-1), an adhesion receptor that mediates inflammatory and immune responses, undergoes shedding in the presence of inflammatory mediators and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	179-210	intercellular adhesion molecule 1	Homo sapiens	35-41
16332693-2	2006	Intercellular adhesion molecule-1 (ICAM-1), an adhesion receptor that mediates inflammatory and immune responses, undergoes shedding in the presence of inflammatory mediators and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	212-215	intercellular adhesion molecule 1	Homo sapiens	0-33
16332693-2	2006	Intercellular adhesion molecule-1 (ICAM-1), an adhesion receptor that mediates inflammatory and immune responses, undergoes shedding in the presence of inflammatory mediators and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	212-215	intercellular adhesion molecule 1	Homo sapiens	35-41
16610234-7	2006	In contrast, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) had no effect on Runx2 transcription, but induced an increase in osterix mRNA level at the concentration of 500 nM at 12 h after treatment.	Tetradecanoylphorbol Acetate	50-81	Sp7 transcription factor	Rattus norvegicus	153-160
16610234-7	2006	In contrast, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) had no effect on Runx2 transcription, but induced an increase in osterix mRNA level at the concentration of 500 nM at 12 h after treatment.	Tetradecanoylphorbol Acetate	83-86	Sp7 transcription factor	Rattus norvegicus	153-160
16610234-8	2006	Moreover, pre-treatment of the cells with calphostin C, a PKC-specific inhibitor, reduced the increase in osterix transcripts enhanced by PTH and PMA 12 h after treatment.	Tetradecanoylphorbol Acetate	146-149	Sp7 transcription factor	Rattus norvegicus	106-113
16420573-9	2006	The ex vivo activity of antithrombotic doses of PCI was also demonstrated by the enhanced lysis of whole blood clots formed in a thrombelastograph with the addition of a sub-threshold concentration of tPA.	Tetradecanoylphorbol Acetate	201-204	serine (or cysteine) peptidase inhibitor, clade A, member 5	Mus musculus	48-51
16452716-6	2006	MARCKS phosphorylation was demonstrated upon PKC activation, whereas a PKC inhibitor (myrPKCpsi) prevented both MARCKS translocation and CGE in 12-O-tetradecanoyl phorbol-13-acetate (TPA)-activated eggs.	Tetradecanoylphorbol Acetate	183-186	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	0-6
16452716-6	2006	MARCKS phosphorylation was demonstrated upon PKC activation, whereas a PKC inhibitor (myrPKCpsi) prevented both MARCKS translocation and CGE in 12-O-tetradecanoyl phorbol-13-acetate (TPA)-activated eggs.	Tetradecanoylphorbol Acetate	183-186	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	112-118
16380122-3	2006	sibirica, on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in MCF10A human breast epithelial cells.	Tetradecanoylphorbol Acetate	77-113	matrix metallopeptidase 9	Homo sapiens	41-46
16380122-3	2006	sibirica, on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in MCF10A human breast epithelial cells.	Tetradecanoylphorbol Acetate	115-118	matrix metallopeptidase 9	Homo sapiens	41-46
16380122-4	2006	Treatment of MCF10A cells with TPA led to the expression of COX-2 and MMP-9.	Tetradecanoylphorbol Acetate	31-34	matrix metallopeptidase 9	Homo sapiens	70-75
16380122-7	2006	The upregulation of MMP-9 by TPA was also significantly reduced by hirsutenone.	Tetradecanoylphorbol Acetate	29-32	matrix metallopeptidase 9	Homo sapiens	20-25
16380122-11	2006	Treatment of MCF10A cells with N-alpha-Tosyl-l-phenylalanine chloromethyl ketone, a specific inhibitor of NF-kappaB, reduced the TPA-induced expression of COX-2 and MMP-9.	Tetradecanoylphorbol Acetate	129-132	matrix metallopeptidase 9	Homo sapiens	165-170
16380122-12	2006	In summary, hirsutenone inhibits the TPA-induced upregulation of COX-2 and MMP-9 in human breast epithelial cells, possibly by targeting NF-kappaB, which may contribute to its chemopreventive effects.	Tetradecanoylphorbol Acetate	37-40	matrix metallopeptidase 9	Homo sapiens	75-80
17193924-5	2006	Furthermore, upregulation of three candidate genes (NFIL3, SKIL, and JMJD3) was shown to be dosage and time dependent with TPA treatment and was found to be directly regulated by TPA through PKC-dependent signaling.	Tetradecanoylphorbol Acetate	123-126	SKI like proto-oncogene	Homo sapiens	59-63
17193924-5	2006	Furthermore, upregulation of three candidate genes (NFIL3, SKIL, and JMJD3) was shown to be dosage and time dependent with TPA treatment and was found to be directly regulated by TPA through PKC-dependent signaling.	Tetradecanoylphorbol Acetate	123-126	lysine demethylase 6B	Homo sapiens	69-74
17193924-5	2006	Furthermore, upregulation of three candidate genes (NFIL3, SKIL, and JMJD3) was shown to be dosage and time dependent with TPA treatment and was found to be directly regulated by TPA through PKC-dependent signaling.	Tetradecanoylphorbol Acetate	179-182	SKI like proto-oncogene	Homo sapiens	59-63
17193924-5	2006	Furthermore, upregulation of three candidate genes (NFIL3, SKIL, and JMJD3) was shown to be dosage and time dependent with TPA treatment and was found to be directly regulated by TPA through PKC-dependent signaling.	Tetradecanoylphorbol Acetate	179-182	lysine demethylase 6B	Homo sapiens	69-74
16275890-2	2006	In this study, rac2-/- neutrophils were shown to have significantly decreased NADPH oxidase activity and actin remodeling in response to exogenous arachidonic acid (AA), as previously observed for phorbol 12-myristate 13-acetate (PMA) or formyl-Met-Leu-Phe (fMLP) as agonists.	Tetradecanoylphorbol Acetate	197-228	Rac family small GTPase 2	Mus musculus	15-19
16275890-2	2006	In this study, rac2-/- neutrophils were shown to have significantly decreased NADPH oxidase activity and actin remodeling in response to exogenous arachidonic acid (AA), as previously observed for phorbol 12-myristate 13-acetate (PMA) or formyl-Met-Leu-Phe (fMLP) as agonists.	Tetradecanoylphorbol Acetate	230-233	Rac family small GTPase 2	Mus musculus	15-19
16275890-7	2006	In addition, PMA-stimulated release of AA and cytoplasmic phospholipase A2 expression in rac2-/- neutrophils were similar to wild-type, suggesting that deficient AA production by PMA-stimulated rac2-/- neutrophils does not explain the effect of exogenous AA on oxidase activity.	Tetradecanoylphorbol Acetate	13-16	phospholipase A2, group IB, pancreas	Mus musculus	58-74
16275890-7	2006	In addition, PMA-stimulated release of AA and cytoplasmic phospholipase A2 expression in rac2-/- neutrophils were similar to wild-type, suggesting that deficient AA production by PMA-stimulated rac2-/- neutrophils does not explain the effect of exogenous AA on oxidase activity.	Tetradecanoylphorbol Acetate	13-16	Rac family small GTPase 2	Mus musculus	89-93
16275890-7	2006	In addition, PMA-stimulated release of AA and cytoplasmic phospholipase A2 expression in rac2-/- neutrophils were similar to wild-type, suggesting that deficient AA production by PMA-stimulated rac2-/- neutrophils does not explain the effect of exogenous AA on oxidase activity.	Tetradecanoylphorbol Acetate	13-16	Rac family small GTPase 2	Mus musculus	194-198
16275890-7	2006	In addition, PMA-stimulated release of AA and cytoplasmic phospholipase A2 expression in rac2-/- neutrophils were similar to wild-type, suggesting that deficient AA production by PMA-stimulated rac2-/- neutrophils does not explain the effect of exogenous AA on oxidase activity.	Tetradecanoylphorbol Acetate	179-182	Rac family small GTPase 2	Mus musculus	194-198
16242794-6	2005	Phorbol myristate acetate (PMA), a protein kinase C (PKC) activator, completely prevented Ang II-stimulated eNOS protein expression at 8 h, whereas depletion of PKC by long-term treatment with PMA, induced eNOS protein expression.	Tetradecanoylphorbol Acetate	0-25	protein kinase C alpha	Bos taurus	53-56
15953625-5	2005	Our results demonstrate that extracts of broccoli and Rorripa suppressed TPA-induced MMP-9 activity and invasiveness in a concentration dependent manner as determined by zymographic analysis.	Tetradecanoylphorbol Acetate	73-76	matrix metallopeptidase 9	Homo sapiens	85-90
16271356-6	2005	Exposure to PMA for 1-2 days additionally induced down-regulation of claudin-2 and up-regulation of barrier modulating matrix metalloproteinase (MMP)-9, respectively.	Tetradecanoylphorbol Acetate	12-15	matrix metallopeptidase 9	Homo sapiens	119-151
16179364-4	2005	When we applied phorbol 12-myristate 13-acetate (PMA), a potent PKC activator, we observed a large positive shift (17.8 +/- 1.6 mV) in the G-V curve for KCNQ2, while chelerythrine, a PKC inhibitor, attenuated the shift caused by the stimulation of M1 receptors.	Tetradecanoylphorbol Acetate	16-47	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	153-158
16179364-4	2005	When we applied phorbol 12-myristate 13-acetate (PMA), a potent PKC activator, we observed a large positive shift (17.8 +/- 1.6 mV) in the G-V curve for KCNQ2, while chelerythrine, a PKC inhibitor, attenuated the shift caused by the stimulation of M1 receptors.	Tetradecanoylphorbol Acetate	49-52	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	153-158
16306704-1	2005	Stimulation of normal mouse neutrophils with phorbol 12-myristate 13-acetate resulted in an acceleration of chromatin condensation and phosphatidylserine externalization that was not associated with caspase-3 activation.	Tetradecanoylphorbol Acetate	45-76	caspase 3	Mus musculus	199-208
16306704-4	2005	Of note, p38 mitogen-activated protein kinase was activated by phorbol 12-myristate 13-acetate in normal and myeloperoxidase-deficient neutrophils lacking production of HOCl, whereas no activation was observed in NADPH oxidase-deficient neutrophils.	Tetradecanoylphorbol Acetate	63-94	myeloperoxidase	Mus musculus	109-124
16172133-4	2005	Ex vivo stimulation of DP thymocytes with phorbol myristate acetate or antibodies that activate the TCR complex led to the accumulation of DRAK2 in a protein kinase C- and MAP Kinase-dependent fashion.	Tetradecanoylphorbol Acetate	42-67	serine/threonine kinase 17b	Homo sapiens	139-144
16044159-6	2005	Isolated TPA applications induced Caspase-3 activation and apoptosis in nontransformed mouse epidermal tissues.	Tetradecanoylphorbol Acetate	9-12	caspase 3	Mus musculus	34-43
16044159-7	2005	The induction of both Caspase-3 and apoptosis by TPA were four-fold inhibited in the skin of the Tg(ped/pea-15) compared to the nontransgenic mice, accompanied by a similarly sized reduction in TPA-induced JNK and p38 stimulation and by constitutive induction of cytoplasmic ERK activity in the transgenics.	Tetradecanoylphorbol Acetate	49-52	caspase 3	Mus musculus	22-31
16044159-9	2005	In the A5 spindle carcinoma cell line, antisense inhibition of ped/pea-15 expression simultaneously rescued sensitivity to TPA-induced Caspase-3 function and apoptosis.	Tetradecanoylphorbol Acetate	123-126	caspase 3	Mus musculus	135-144
16188940-7	2005	We find that the behavior of Bves following low Ca2+ challenge or TPA treatment mimics that observed for ZO-1 and is distinct from adherens junction proteins such as E-cadherin.	Tetradecanoylphorbol Acetate	66-69	blood vessel epicardial substance	Mus musculus	29-33
15976391-0	2005	Zinc finger transcription factor Egr-1 is involved in stimulation of NHE2 gene expression by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	93-124	solute carrier family 9 member A2	Homo sapiens	69-73
15976391-5	2005	RT-PCR analysis showed that NHE2 mRNA was upregulated in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	69-100	solute carrier family 9 member A2	Homo sapiens	28-32
15976391-5	2005	RT-PCR analysis showed that NHE2 mRNA was upregulated in response to phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	102-105	solute carrier family 9 member A2	Homo sapiens	28-32
16277846-0	2005	[JWA gene in regulating committed differentiation of HL-60 cells induced by ATRA, Ara-C and TPA].	Tetradecanoylphorbol Acetate	92-95	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	1-4
16166335-6	2005	Furthermore, cells that were pretreated with 100 nmol/L 12-O-tetradecanoyl phorbol-13-acetate, and then treated with 25 micromol/L PEITC-NAC, underwent enhanced apoptosis compared with cells that were treated with PEITC-NAC alone; cells treated with 12-O-tetradecanoyl phorbol-13-acetate alone showed active cell growth without apoptosis.	Tetradecanoylphorbol Acetate	56-93	X-linked Kx blood group	Homo sapiens	137-140
16166335-6	2005	Furthermore, cells that were pretreated with 100 nmol/L 12-O-tetradecanoyl phorbol-13-acetate, and then treated with 25 micromol/L PEITC-NAC, underwent enhanced apoptosis compared with cells that were treated with PEITC-NAC alone; cells treated with 12-O-tetradecanoyl phorbol-13-acetate alone showed active cell growth without apoptosis.	Tetradecanoylphorbol Acetate	56-93	X-linked Kx blood group	Homo sapiens	220-223
16166335-6	2005	Furthermore, cells that were pretreated with 100 nmol/L 12-O-tetradecanoyl phorbol-13-acetate, and then treated with 25 micromol/L PEITC-NAC, underwent enhanced apoptosis compared with cells that were treated with PEITC-NAC alone; cells treated with 12-O-tetradecanoyl phorbol-13-acetate alone showed active cell growth without apoptosis.	Tetradecanoylphorbol Acetate	250-287	X-linked Kx blood group	Homo sapiens	137-140
16027158-6	2005	Rat2 fibroblasts expressing the Coronin 1B S2A mutant show enhanced ruffling in response to phorbol 12-myristate 13-acetate (PMA) and increased speed in single cell tracking assays.	Tetradecanoylphorbol Acetate	92-123	coronin 1B	Homo sapiens	32-42
16027158-6	2005	Rat2 fibroblasts expressing the Coronin 1B S2A mutant show enhanced ruffling in response to phorbol 12-myristate 13-acetate (PMA) and increased speed in single cell tracking assays.	Tetradecanoylphorbol Acetate	125-128	coronin 1B	Homo sapiens	32-42
16123426-3	2005	METHODS: Whole rat lenses were treated with phorbol-12-myristate-13-acetate (TPA) to activate PKCgamma or the inactive analogue 4alpha-phorbol,12,13-didecaneote (PDD) as a control.	Tetradecanoylphorbol Acetate	44-75	protein kinase C, gamma	Rattus norvegicus	94-102
16123426-3	2005	METHODS: Whole rat lenses were treated with phorbol-12-myristate-13-acetate (TPA) to activate PKCgamma or the inactive analogue 4alpha-phorbol,12,13-didecaneote (PDD) as a control.	Tetradecanoylphorbol Acetate	77-80	protein kinase C, gamma	Rattus norvegicus	94-102
16123426-5	2005	RESULTS: Treatment with TPA activated PKCgamma and uncoupled the lens cortex by approximately 60%.	Tetradecanoylphorbol Acetate	24-27	protein kinase C, gamma	Rattus norvegicus	38-46
16042408-3	2005	In vivo phosphorylation studies in COS-1 cells transfected with murine PPARalpha showed that the level of phosphorylated PPARalpha is increased by treatment with the PP Wy-14,643 as well as the PKC activator phorbol myristol acetate (PMA).	Tetradecanoylphorbol Acetate	234-237	protein kinase C, alpha	Rattus norvegicus	194-197
15744749-3	2005	Phosphorylation of MAPK/ERK was mimicked by phorbol 12-myristate acetate (PMA), an activator of protein kinase C (PKC), but Cch-evoked MAPK/ERK activation was unaffected by down-regulation of PKC or by pretreatment of cells with GF109203X, a PKC inhibitor.	Tetradecanoylphorbol Acetate	74-77	protein kinase C zeta	Homo sapiens	114-117
15863510-3	2005	Ascochlorin reduced the invasive activity of Caki-1 cells and inhibited phorbol 12-myristate 13-acetate-induced increases in MMP-9 expression and activity in a dose-dependent manner.	Tetradecanoylphorbol Acetate	72-103	matrix metallopeptidase 9	Homo sapiens	125-130
15863510-7	2005	Moreover, transfection of Caki-1 cells with AP-1 decoy oligodeoxynucleotides resulted in the suppression of phorbol 12-myristate 13-acetate-induced MMP-9 expression and invasion.	Tetradecanoylphorbol Acetate	108-139	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	44-48
15863510-7	2005	Moreover, transfection of Caki-1 cells with AP-1 decoy oligodeoxynucleotides resulted in the suppression of phorbol 12-myristate 13-acetate-induced MMP-9 expression and invasion.	Tetradecanoylphorbol Acetate	108-139	matrix metallopeptidase 9	Homo sapiens	148-153
15910736-4	2005	Expression experiments using mitogen-activated protein kinase phosphatase-1 or a dominant-negative mutant of the ternary complex factor Elk-1 revealed that the distal cluster of serum response elements is essential in the TPA-induced enhancement of Egr-1 promoter activity, encompassing two independent TPA-responsive elements.	Tetradecanoylphorbol Acetate	222-225	ETS transcription factor ELK1	Homo sapiens	136-141
15892717-9	2005	In contrast to the activating effect of cAMP inducers, 12-O-tetradecanoylphorbolacetate (TPA) was a potent repressor of DCT transcription, suggesting that this gene can be differentially regulated by multiple environmental signals and promoter context.	Tetradecanoylphorbol Acetate	55-87	dopachrome tautomerase	Homo sapiens	120-123
15892717-9	2005	In contrast to the activating effect of cAMP inducers, 12-O-tetradecanoylphorbolacetate (TPA) was a potent repressor of DCT transcription, suggesting that this gene can be differentially regulated by multiple environmental signals and promoter context.	Tetradecanoylphorbol Acetate	89-92	dopachrome tautomerase	Homo sapiens	120-123
15743775-9	2005	Stimulation of TE671 cells with 12-O-tetradecanoylphorbol-13-acetate or transfection with protein kinase Calpha expression vector induced phosphorylation of Hes-1, inhibition of DNA binding of Hes-1 to the N-box, and activation of the AP-2beta function to up-regulate L-PGDS gene expression.	Tetradecanoylphorbol Acetate	32-68	transcription factor AP-2 beta	Homo sapiens	235-243
15831482-0	2005	Selective regulation of c-jun gene expression by mitogen-activated protein kinases via the 12-o-tetradecanoylphorbol-13-acetate- responsive element and myocyte enhancer factor 2 binding sites.	Tetradecanoylphorbol Acetate	91-127	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	24-29
15804434-1	2005	We have previously demonstrated that pressure application of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) onto some neurons in the anterior hypothalamic area of rats increases neural activity in vivo and that this PKC activation-induced increase of neural activity is enhanced in spontaneously hypertensive rats (SHR), an animal model for genetic hypertension.	Tetradecanoylphorbol Acetate	98-129	protein kinase C, alpha	Rattus norvegicus	83-86
15804434-1	2005	We have previously demonstrated that pressure application of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) onto some neurons in the anterior hypothalamic area of rats increases neural activity in vivo and that this PKC activation-induced increase of neural activity is enhanced in spontaneously hypertensive rats (SHR), an animal model for genetic hypertension.	Tetradecanoylphorbol Acetate	98-129	protein kinase C, alpha	Rattus norvegicus	244-247
15804434-1	2005	We have previously demonstrated that pressure application of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) onto some neurons in the anterior hypothalamic area of rats increases neural activity in vivo and that this PKC activation-induced increase of neural activity is enhanced in spontaneously hypertensive rats (SHR), an animal model for genetic hypertension.	Tetradecanoylphorbol Acetate	131-134	protein kinase C, alpha	Rattus norvegicus	83-86
15804434-1	2005	We have previously demonstrated that pressure application of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) onto some neurons in the anterior hypothalamic area of rats increases neural activity in vivo and that this PKC activation-induced increase of neural activity is enhanced in spontaneously hypertensive rats (SHR), an animal model for genetic hypertension.	Tetradecanoylphorbol Acetate	131-134	protein kinase C, alpha	Rattus norvegicus	244-247
15804434-4	2005	PMA increased c-fos gene expression in neuronal cultures of Wistar rat brain and the PMA-induced c-fos gene expression was inhibited by the PKC inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7).	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-19
15804434-4	2005	PMA increased c-fos gene expression in neuronal cultures of Wistar rat brain and the PMA-induced c-fos gene expression was inhibited by the PKC inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7).	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	97-102
15804434-7	2005	In SHR brain neuronal cultures, the PMA-induced c-fos gene expression was enhanced as compared with that of Wistar Kyoto rats (WKY), while basal c-fos gene expression was almost the same in both neuronal cultures.	Tetradecanoylphorbol Acetate	36-39	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-53
15788229-0	2005	Tumor promoter TPA stimulates MMP-9 secretion from human keratinocytes by activation of superoxide-producing NADPH oxidase.	Tetradecanoylphorbol Acetate	15-18	matrix metallopeptidase 9	Homo sapiens	30-35
15788229-2	2005	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) increases MMP-9 secretion from normal human epidermal keratinocytes (NHEK) in vivo and in vitro.	Tetradecanoylphorbol Acetate	19-55	matrix metallopeptidase 9	Homo sapiens	72-77
15788229-2	2005	The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) increases MMP-9 secretion from normal human epidermal keratinocytes (NHEK) in vivo and in vitro.	Tetradecanoylphorbol Acetate	57-60	matrix metallopeptidase 9	Homo sapiens	72-77
15788229-3	2005	Here we show that the flavoprotein inhibitor diphenyleneiodinium (DPI) and the NADPH oxidase inhibitor apocynin block TPA-induced MMP-9 secretion of NHEK in vitro.	Tetradecanoylphorbol Acetate	118-121	matrix metallopeptidase 9	Homo sapiens	130-135
15788229-4	2005	Furthermore, N-acetyl-L-cysteine and L-cysteine lowered TPA-induced MMP-9 secretion, suggesting an involvement of reactive oxygen species(ROS).	Tetradecanoylphorbol Acetate	56-59	matrix metallopeptidase 9	Homo sapiens	68-73
15705907-3	2005	We attempted to clarify the mechanisms and found that activator protein (AP-1) is probably one of the key factors in the transcriptional regulation of DPYD in cancer cells, and that phorbol 12-myristate 13-acetate (PMA) plus ionomycin treatment enhances transcription of DPYD via AP-1 activation.	Tetradecanoylphorbol Acetate	182-213	dihydropyrimidine dehydrogenase	Homo sapiens	151-155
15705907-3	2005	We attempted to clarify the mechanisms and found that activator protein (AP-1) is probably one of the key factors in the transcriptional regulation of DPYD in cancer cells, and that phorbol 12-myristate 13-acetate (PMA) plus ionomycin treatment enhances transcription of DPYD via AP-1 activation.	Tetradecanoylphorbol Acetate	182-213	dihydropyrimidine dehydrogenase	Homo sapiens	271-275
15705907-7	2005	PMA/ionomycin treatment increased the mRNA level of DPYD in HSC42 cells, and electrophoretic gel mobility shift assay showed that the complex on the putative AP-1 binding site was drastically induced by PMA/ionomycin treatment.	Tetradecanoylphorbol Acetate	0-3	dihydropyrimidine dehydrogenase	Homo sapiens	52-56
15513920-8	2005	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate blunted VR1 desensitization, and this effect was reversible in the presence of the PKC inhibitor bisindolylmaleimide I.	Tetradecanoylphorbol Acetate	37-68	protein kinase C, gamma	Rattus norvegicus	4-20
15513920-8	2005	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate blunted VR1 desensitization, and this effect was reversible in the presence of the PKC inhibitor bisindolylmaleimide I.	Tetradecanoylphorbol Acetate	37-68	protein kinase C, gamma	Rattus norvegicus	22-25
15513920-8	2005	The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate blunted VR1 desensitization, and this effect was reversible in the presence of the PKC inhibitor bisindolylmaleimide I.	Tetradecanoylphorbol Acetate	37-68	protein kinase C, gamma	Rattus norvegicus	152-155
15947482-6	2005	RESULTS: The PKC zeta inhibitor significantly blocked FMLP- or PMA-induced O(2)(-) generation by eosinophils.	Tetradecanoylphorbol Acetate	63-66	protein kinase C zeta	Homo sapiens	13-21
15308560-4	2004	ATRA- and phorbol 12-myristate 13-acetate (PMA)-induced monocytic differentiation is accompanied by increased PLSCR1 expression, whereas only a slight or no elevation of PLSCR1 expression is observed in U937 cells differentiated with dimethyl sulfoxide (DMSO), sodium butyrate, or vitamin D3.	Tetradecanoylphorbol Acetate	10-41	phospholipid scramblase 1	Homo sapiens	110-116
15308560-4	2004	ATRA- and phorbol 12-myristate 13-acetate (PMA)-induced monocytic differentiation is accompanied by increased PLSCR1 expression, whereas only a slight or no elevation of PLSCR1 expression is observed in U937 cells differentiated with dimethyl sulfoxide (DMSO), sodium butyrate, or vitamin D3.	Tetradecanoylphorbol Acetate	43-46	phospholipid scramblase 1	Homo sapiens	110-116
15308560-5	2004	Cell differentiation with ATRA and PMA, but not with vitamin D3 or DMSO, results in phosphorylation of protein kinase Cdelta (PKCdelta), and the PKCdelta-specific inhibitor rottlerin nearly eliminates the ATRA- and PMA-induced expression of PLSCR1, while ectopic expression of a constitutively active form of PKCdelta directly increases PLSCR1 expression.	Tetradecanoylphorbol Acetate	35-38	phospholipid scramblase 1	Homo sapiens	241-247
15308560-5	2004	Cell differentiation with ATRA and PMA, but not with vitamin D3 or DMSO, results in phosphorylation of protein kinase Cdelta (PKCdelta), and the PKCdelta-specific inhibitor rottlerin nearly eliminates the ATRA- and PMA-induced expression of PLSCR1, while ectopic expression of a constitutively active form of PKCdelta directly increases PLSCR1 expression.	Tetradecanoylphorbol Acetate	35-38	phospholipid scramblase 1	Homo sapiens	337-343
15582138-4	2004	Using intracellular staining and flow cytometry, we assessed the ability of freshly isolated liver T cells from these biopsies to produce IFN-gamma, TNF-alpha, IL-2, IL-4, and IL-10 in response to stimulation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	214-217	interleukin 10	Homo sapiens	176-181
15620108-6	2004	The fluorescence of CD18 and CD11b reappeared on the cell membrane 1 h after re-treatment with PMA, suggesting the recycling of non-degraded Mac-1.	Tetradecanoylphorbol Acetate	95-98	integrin subunit alpha M	Homo sapiens	29-34
15620108-6	2004	The fluorescence of CD18 and CD11b reappeared on the cell membrane 1 h after re-treatment with PMA, suggesting the recycling of non-degraded Mac-1.	Tetradecanoylphorbol Acetate	95-98	integrin subunit alpha M	Homo sapiens	141-146
15496510-6	2004	Furthermore, PMA-induced, but not DAMGO-induced, HmuOR phosphorylation was partially inhibited by the coexpression of PKCI, suggesting that PKCI exerts a selective regulatory effect on HmuOR signaling.	Tetradecanoylphorbol Acetate	13-16	protein kinase C, iota	Mus musculus	118-122
15496510-6	2004	Furthermore, PMA-induced, but not DAMGO-induced, HmuOR phosphorylation was partially inhibited by the coexpression of PKCI, suggesting that PKCI exerts a selective regulatory effect on HmuOR signaling.	Tetradecanoylphorbol Acetate	13-16	protein kinase C, iota	Mus musculus	140-144
15501252-8	2004	Topical application of curcumin, 10, 13, 21, and 6, a methoxy derivative of curcumin, showed strong inhibition of 12-O-tetradecanoyl-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in mouse skin.	Tetradecanoylphorbol Acetate	145-148	ornithine decarboxylase, structural 1	Mus musculus	158-181
15501252-8	2004	Topical application of curcumin, 10, 13, 21, and 6, a methoxy derivative of curcumin, showed strong inhibition of 12-O-tetradecanoyl-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in mouse skin.	Tetradecanoylphorbol Acetate	145-148	ornithine decarboxylase, structural 1	Mus musculus	183-186
15378003-7	2004	We also show that all KLF6 effects on c-Jun were largely dependent on phorbol ester (TPA/ionomycin) extracellular stimulation, which enhanced KLF6 nuclear translocation and transcriptional activity and modified its phosphorylation status.	Tetradecanoylphorbol Acetate	85-88	Kruppel like factor 6	Homo sapiens	22-26
15378003-7	2004	We also show that all KLF6 effects on c-Jun were largely dependent on phorbol ester (TPA/ionomycin) extracellular stimulation, which enhanced KLF6 nuclear translocation and transcriptional activity and modified its phosphorylation status.	Tetradecanoylphorbol Acetate	85-88	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-43
15378003-7	2004	We also show that all KLF6 effects on c-Jun were largely dependent on phorbol ester (TPA/ionomycin) extracellular stimulation, which enhanced KLF6 nuclear translocation and transcriptional activity and modified its phosphorylation status.	Tetradecanoylphorbol Acetate	85-88	Kruppel like factor 6	Homo sapiens	142-146
15470039-4	2004	For NK1/NK2 cell differentiation, initial stimulation with PMA and ionomycin was required.	Tetradecanoylphorbol Acetate	59-62	hepatocyte growth factor	Mus musculus	8-11
15470039-8	2004	After stimulation with PMA and ionomycin, NK cells expressed IL-2Ralpha.	Tetradecanoylphorbol Acetate	23-26	interleukin 2 receptor, alpha chain	Mus musculus	61-71
15355467-8	2004	Nonspecific stimulus with calcium ionophore and phorbol-myristate-acetate of BM CD34(+) cells caused release of IL-5, IL-3 and GM-CSF.	Tetradecanoylphorbol Acetate	48-73	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	127-133
15218074-1	2004	SPOC1 airway goblet cells secrete mucin in response to P2Y2 receptor agonists and to secretagogues, phorbol 12-myristate 13-acetate (PMA) and ionomycin, which mobilize elements of the phospholipase C pathway, PKC and Ca2+, respectively.	Tetradecanoylphorbol Acetate	100-131	solute carrier family 13 member 2	Rattus norvegicus	34-39
15218074-1	2004	SPOC1 airway goblet cells secrete mucin in response to P2Y2 receptor agonists and to secretagogues, phorbol 12-myristate 13-acetate (PMA) and ionomycin, which mobilize elements of the phospholipase C pathway, PKC and Ca2+, respectively.	Tetradecanoylphorbol Acetate	133-136	solute carrier family 13 member 2	Rattus norvegicus	34-39
15218074-3	2004	We tested the alternative hypothesis that PMA-induced mucin secretion is, in fact, a Ca2+-dependent process under the conditions of low bulk Ca2+, one that is permitted in the typical SLO-permeabilized cell model by the slow binding kinetics of EGTA.	Tetradecanoylphorbol Acetate	42-45	solute carrier family 13 member 2	Rattus norvegicus	54-59
15314167-2	2004	Immunofluorescence analysis demonstrated that activation of PKCalpha by phorbol 12-myristate 13-acetate (PMA), or ectopic expression of constitutively activated PKCalpha, directs AFAP-110 to colocalize with and bind to the c-Src SH3 domain, resulting in activation of the tyrosine kinase.	Tetradecanoylphorbol Acetate	72-103	actin filament associated protein 1	Homo sapiens	179-187
15358156-3	2004	Here we report that phorbol 12-myristate 13-acetate (PMA) up-regulates cPLA(2)alpha in A549 airway epithelium cells, and that this effect is sensitive to rottlerin, a potent inhibitor of protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	20-51	phospholipase A2 group IVA	Homo sapiens	71-83
15358156-3	2004	Here we report that phorbol 12-myristate 13-acetate (PMA) up-regulates cPLA(2)alpha in A549 airway epithelium cells, and that this effect is sensitive to rottlerin, a potent inhibitor of protein kinase Cdelta (PKCdelta).	Tetradecanoylphorbol Acetate	53-56	phospholipase A2 group IVA	Homo sapiens	71-83
15279563-9	2004	MAO B, but not MAO A gene, could be activated by PMA (phorbol 12-myristate 13-acetate) by protein kinase C, MAPkinase signal transduction pathway involves cJun and Egr-1.	Tetradecanoylphorbol Acetate	54-85	monoamine oxidase B	Homo sapiens	0-5
15279563-9	2004	MAO B, but not MAO A gene, could be activated by PMA (phorbol 12-myristate 13-acetate) by protein kinase C, MAPkinase signal transduction pathway involves cJun and Egr-1.	Tetradecanoylphorbol Acetate	54-85	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	155-159
15464363-3	2004	It contains a functionally active AP-1 site (TPA Responsive Element, TRE) which is essential for the high transcriptional activity of the COL10A1 enhancer in transiently transfected hypertrophic chondrocytes.	Tetradecanoylphorbol Acetate	45-48	tRNA-Glu (anticodon TTC) 3-1	Homo sapiens	69-72
15190214-6	2004	Upon treatment with phorbol 12-myristate 13-acetate (PMA), human erythroleukemic cells (K562) underwent megakaryocytic differentiation characterized by polyploidization and expression of mature megakaryocyte surface markers such as CD41.	Tetradecanoylphorbol Acetate	20-51	integrin subunit alpha 2b	Homo sapiens	232-236
15190214-6	2004	Upon treatment with phorbol 12-myristate 13-acetate (PMA), human erythroleukemic cells (K562) underwent megakaryocytic differentiation characterized by polyploidization and expression of mature megakaryocyte surface markers such as CD41.	Tetradecanoylphorbol Acetate	53-56	integrin subunit alpha 2b	Homo sapiens	232-236
15033986-5	2004	Phorbol 12-myristate 13-acetate-dependent generation of IP(T) was completely blocked in NIH3T3 cells depleted of PLC-gamma1 by RNA interference.	Tetradecanoylphorbol Acetate	0-31	phospholipase C, gamma 1	Mus musculus	113-123
15066986-6	2004	Cotransfection of TACE in EC-2 cells enhanced phorbol myristate acetate-induced but not constitutive shedding of epiregulin and had no effect on betacellulin (BTC) processing.	Tetradecanoylphorbol Acetate	46-71	ADAM metallopeptidase domain 17	Homo sapiens	18-22
14966080-5	2004	The PKC activators phorbol myristate acetate (PMA) and thymeleatoxin opened BK(Ca) channels in single Sprague-Dawley rat PASMC.	Tetradecanoylphorbol Acetate	19-44	protein kinase C, alpha	Rattus norvegicus	4-7
14966080-5	2004	The PKC activators phorbol myristate acetate (PMA) and thymeleatoxin opened BK(Ca) channels in single Sprague-Dawley rat PASMC.	Tetradecanoylphorbol Acetate	46-49	protein kinase C, alpha	Rattus norvegicus	4-7
15172994-4	2004	Nuclear accumulation of the pHisG-MLTK-alpha fusion protein was observed after epidermal growth factor or 12-O-tetradecanoylphorbol-13-acetate treatment.	Tetradecanoylphorbol Acetate	106-142	mitogen-activated protein kinase kinase kinase 20	Mus musculus	34-44
15172994-5	2004	Phosphorylation of downstream mitogen-activated protein kinase-targeted transcription factors including c-Myc, Elk-1, c-Jun, and activating transcription factor (ATF) 2 was also differentially enhanced in MLTK-alpha-overexpressing cells exposed to epidermal growth factor or 12-O-tetradecanoylphorbol-13-acetate stimulation compared with cells expressing mock vector or siRNA-MLTK-alpha.	Tetradecanoylphorbol Acetate	275-311	mitogen-activated protein kinase kinase kinase 20	Mus musculus	205-209
15172994-5	2004	Phosphorylation of downstream mitogen-activated protein kinase-targeted transcription factors including c-Myc, Elk-1, c-Jun, and activating transcription factor (ATF) 2 was also differentially enhanced in MLTK-alpha-overexpressing cells exposed to epidermal growth factor or 12-O-tetradecanoylphorbol-13-acetate stimulation compared with cells expressing mock vector or siRNA-MLTK-alpha.	Tetradecanoylphorbol Acetate	275-311	mitogen-activated protein kinase kinase kinase 20	Mus musculus	205-215
15161746-1	2004	Effects of diverse stimuli, including insulin, muscle contraction, and phorbol 12-myristate-13-acetate (PMA), were determined on phosphorylation of mitogen-activated protein kinase (MAPK) signaling modules (c-Jun NH(2)-terminal kinase [JNK], p38 MAPK, and extracellular signal-related kinase [ERK1/2]) in skeletal muscle from lean and ob/ob mice.	Tetradecanoylphorbol Acetate	71-102	mitogen-activated protein kinase 8	Mus musculus	207-234
15161746-1	2004	Effects of diverse stimuli, including insulin, muscle contraction, and phorbol 12-myristate-13-acetate (PMA), were determined on phosphorylation of mitogen-activated protein kinase (MAPK) signaling modules (c-Jun NH(2)-terminal kinase [JNK], p38 MAPK, and extracellular signal-related kinase [ERK1/2]) in skeletal muscle from lean and ob/ob mice.	Tetradecanoylphorbol Acetate	71-102	mitogen-activated protein kinase 8	Mus musculus	236-239
15161746-1	2004	Effects of diverse stimuli, including insulin, muscle contraction, and phorbol 12-myristate-13-acetate (PMA), were determined on phosphorylation of mitogen-activated protein kinase (MAPK) signaling modules (c-Jun NH(2)-terminal kinase [JNK], p38 MAPK, and extracellular signal-related kinase [ERK1/2]) in skeletal muscle from lean and ob/ob mice.	Tetradecanoylphorbol Acetate	104-107	mitogen-activated protein kinase 8	Mus musculus	207-234
15161746-9	2004	In addition, PMA-induced phosphorylation of JNK and ERK1/2 are preserved, whereas p38 MAPK pathways are impaired in skeletal muscle from ob/ob mice.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 8	Mus musculus	44-47
15138488-8	2004	Thus, TPA stimulated c-Jun through JNK, and JIP-1 effectively blocked JNK.	Tetradecanoylphorbol Acetate	6-9	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-26
15138488-14	2004	Taken together, TPA, probably by stimulation of PKC, phosphorylates JNK, which phosphorylates and increases expression of c-Jun leading to AP-1 activity.	Tetradecanoylphorbol Acetate	16-19	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	122-127
15086447-4	2004	RESULTS: Stimulation with fetal bovine serum (FBS), phorbol 12-myristate 13-acetate (PMA) and ET-1 caused about a doubling of c-fos mRNA.	Tetradecanoylphorbol Acetate	52-83	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	126-131
15086447-4	2004	RESULTS: Stimulation with fetal bovine serum (FBS), phorbol 12-myristate 13-acetate (PMA) and ET-1 caused about a doubling of c-fos mRNA.	Tetradecanoylphorbol Acetate	85-88	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	126-131
14997284-12	2004	ornithine decarboxylase activity and [(3)H]thymidine incorporation into cutaneous DNA, was about 60% lower in TPA-treated mice fed on low iron diet than in normal mice treated with TPA.	Tetradecanoylphorbol Acetate	110-113	ornithine decarboxylase, structural 1	Mus musculus	0-23
14997284-12	2004	ornithine decarboxylase activity and [(3)H]thymidine incorporation into cutaneous DNA, was about 60% lower in TPA-treated mice fed on low iron diet than in normal mice treated with TPA.	Tetradecanoylphorbol Acetate	181-184	ornithine decarboxylase, structural 1	Mus musculus	0-23
15096183-5	2004	The utilization of the PKC inhibitors Go6983, Go6976 and RO-32-0432 demonstrated a role for conventional PKCs (alpha and beta) in the production of TNF-alpha in response to stimulation by lipopolysaccharide and phorbol 12-myristate 13-acetate (PMA)/ionomycin.	Tetradecanoylphorbol Acetate	211-242	protein kinase C zeta	Homo sapiens	23-26
15096183-5	2004	The utilization of the PKC inhibitors Go6983, Go6976 and RO-32-0432 demonstrated a role for conventional PKCs (alpha and beta) in the production of TNF-alpha in response to stimulation by lipopolysaccharide and phorbol 12-myristate 13-acetate (PMA)/ionomycin.	Tetradecanoylphorbol Acetate	244-247	protein kinase C zeta	Homo sapiens	23-26
15096183-8	2004	Cyclic-AMP augmented IL-10 production and cAMP response element binding protein activation upon stimulation by PMA/ionomycin.	Tetradecanoylphorbol Acetate	111-114	interleukin 10	Homo sapiens	21-26
15140465-8	2004	We also confirmed (using forskolin (20 microM) and phorbol 12-myristate 13-acetate (TPA) (100 nM)) that adenylate cyclase and protein kinase C participate in the downstream signaling responsible for the stimulation of BDNF synthesis, whereas in the regulation of NGF synthesis only the participation of protein kinase C was confirmed.	Tetradecanoylphorbol Acetate	51-82	brain-derived neurotrophic factor	Rattus norvegicus	218-222
15140465-8	2004	We also confirmed (using forskolin (20 microM) and phorbol 12-myristate 13-acetate (TPA) (100 nM)) that adenylate cyclase and protein kinase C participate in the downstream signaling responsible for the stimulation of BDNF synthesis, whereas in the regulation of NGF synthesis only the participation of protein kinase C was confirmed.	Tetradecanoylphorbol Acetate	84-87	brain-derived neurotrophic factor	Rattus norvegicus	218-222
14705967-4	2004	Treatment of hSFs/hOBs with TPA (PMA; 100 nM) reduced IGFBP-4 proteolysis without significantly decreasing the PAPP-A level in the CM (conditioned medium).	Tetradecanoylphorbol Acetate	28-31	insulin like growth factor binding protein 4	Homo sapiens	54-61
14705967-7	2004	In contrast, TPA treatment blocked IGFBP-4 proteolysis but failed to induce a detectable amount of proMBP in the CM.	Tetradecanoylphorbol Acetate	13-16	insulin like growth factor binding protein 4	Homo sapiens	35-42
15034076-9	2004	Stimulation of T cells from nonpregnant females with PMA/ionomycin resulted in IkappaBalpha degradation, p65 translocation, and subsequent production of the Th1 cytokines IFN-gamma and IL-2.	Tetradecanoylphorbol Acetate	53-56	negative elongation factor complex member C/D	Homo sapiens	157-160
15034076-10	2004	In contrast, PMA stimulation had no effect on NF-kappaB activity in T cells from pregnant females, and this was reflected in reduced Th1 cytokine production.	Tetradecanoylphorbol Acetate	13-16	negative elongation factor complex member C/D	Homo sapiens	133-136
15047839-0	2004	Early activation of the Kaposi"s sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway.	Tetradecanoylphorbol Acetate	99-128	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-140
15047839-5	2004	Treatment with TPA proved to significantly induce both AP1 DNA-binding activity and levels of activated phosphorylated cJUN in PEL cells and ectopic expression of cJUN-plus-cFOS-induced RTA protein expression in PEL cells.	Tetradecanoylphorbol Acetate	15-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-58
15047839-5	2004	Treatment with TPA proved to significantly induce both AP1 DNA-binding activity and levels of activated phosphorylated cJUN in PEL cells and ectopic expression of cJUN-plus-cFOS-induced RTA protein expression in PEL cells.	Tetradecanoylphorbol Acetate	15-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	119-123
15047839-5	2004	Treatment with TPA proved to significantly induce both AP1 DNA-binding activity and levels of activated phosphorylated cJUN in PEL cells and ectopic expression of cJUN-plus-cFOS-induced RTA protein expression in PEL cells.	Tetradecanoylphorbol Acetate	15-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	163-167
15047839-5	2004	Treatment with TPA proved to significantly induce both AP1 DNA-binding activity and levels of activated phosphorylated cJUN in PEL cells and ectopic expression of cJUN-plus-cFOS-induced RTA protein expression in PEL cells.	Tetradecanoylphorbol Acetate	15-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	173-177
15047839-6	2004	Cotransfected cJUN plus cFOS or TPA treatment transactivated the KSHV RTA, RAP, and MTA promoters in an AP1-binding site-dependent manner in all three promoters.	Tetradecanoylphorbol Acetate	32-35	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-107
15047839-7	2004	Chromatin immunoprecipitation assays confirmed that cJUN associates with these KSHV target promoters in PEL cells as early as 4 h after TPA treatment.	Tetradecanoylphorbol Acetate	136-139	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-56
15047839-9	2004	Both increased phosphorylated cJUN and AP1 DNA-binding activity was detected as early as 1 h after TPA treatment in PEL cells, suggesting that AP1 activity may be crucial for very early activation of the RAP, MTA, and RTA promoters during the KSHV lytic cycle.	Tetradecanoylphorbol Acetate	99-102	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-34
15047839-9	2004	Both increased phosphorylated cJUN and AP1 DNA-binding activity was detected as early as 1 h after TPA treatment in PEL cells, suggesting that AP1 activity may be crucial for very early activation of the RAP, MTA, and RTA promoters during the KSHV lytic cycle.	Tetradecanoylphorbol Acetate	99-102	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-42
15047839-9	2004	Both increased phosphorylated cJUN and AP1 DNA-binding activity was detected as early as 1 h after TPA treatment in PEL cells, suggesting that AP1 activity may be crucial for very early activation of the RAP, MTA, and RTA promoters during the KSHV lytic cycle.	Tetradecanoylphorbol Acetate	99-102	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	143-146
15047839-9	2004	Both increased phosphorylated cJUN and AP1 DNA-binding activity was detected as early as 1 h after TPA treatment in PEL cells, suggesting that AP1 activity may be crucial for very early activation of the RAP, MTA, and RTA promoters during the KSHV lytic cycle.	Tetradecanoylphorbol Acetate	99-102	ORF50	Human gammaherpesvirus 8	218-221
15047839-11	2004	Therefore, we suggest that the initiating effects of TPA via the AP1 pathway in PEL cells need to be amplified by RTA for full lytic-cycle induction.	Tetradecanoylphorbol Acetate	53-56	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-68
15060166-3	2004	Bach2 is a member of the BTB-basic region leucine zipper factor family and represses transcription activity directed by the 12-O-tetradecanoylphorbol-13-acetate response element, the Maf recognition element, and the antioxidant-responsive element.	Tetradecanoylphorbol Acetate	124-160	BTB domain and CNC homolog 2	Homo sapiens	0-5
15139522-4	2004	The HT-29 C-4 cells were treated for 1 h with various natural chemopreventive agents and challenged with AP-1 stimulators such as 12-O-tetradecanoylphorbol-13-acetate (TPA) or hydrogen peroxide (H2O2) for 6 h. The c-Jun N-terminal kinase (JNK) was examined to understand the effect of these compounds on the upstream signaling activator of AP-1.	Tetradecanoylphorbol Acetate	130-166	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-109
15139522-7	2004	RESULTS: TPA and H2O2 treatments strongly induced AP-1-luciferase activity as expected.	Tetradecanoylphorbol Acetate	9-12	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-54
15004189-4	2004	PMA-treated cells were shown to degrade 35S-sulfated HSPG in endothelial extracellular matrix into fragments of an approximate molecular mass of 5 kDa.	Tetradecanoylphorbol Acetate	0-3	syndecan 2	Homo sapiens	53-57
14661062-3	2004	We found that resveratrol, a phytoalexin present in grapes, significantly inhibits the PMA-induced increase in MMP-9 expression and activity.	Tetradecanoylphorbol Acetate	87-90	matrix metallopeptidase 9	Homo sapiens	111-116
14661063-6	2004	TPA-induced c-Jun expression was transient in TNFR1-/- and TNFR2-/- compared to wt epidermis and this was reflected by reduced induction of the AP-1-responsive genes granulocyte/macrophage-colony stimulating factor, matrix metalloproteinase-9 and matrix metalloproteinase-3.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	46-51
14661063-6	2004	TPA-induced c-Jun expression was transient in TNFR1-/- and TNFR2-/- compared to wt epidermis and this was reflected by reduced induction of the AP-1-responsive genes granulocyte/macrophage-colony stimulating factor, matrix metalloproteinase-9 and matrix metalloproteinase-3.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	59-64
14602579-11	2004	The conductance was partially inhibited by 1,2-dioctanoyl-sn-glycerol and phorbol 12-myristate 13-acetate, both of which activate protein kinase C. These data suggest that 5-HT acts at 5-HT2C receptors to activate protein kinase C, which inhibits the Kv channels.	Tetradecanoylphorbol Acetate	74-105	5-hydroxytryptamine receptor 2C	Rattus norvegicus	185-191
14978237-2	2004	The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2.	Tetradecanoylphorbol Acetate	171-174	signal transducer and activator of transcription 1	Homo sapiens	30-80
14978237-2	2004	The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2.	Tetradecanoylphorbol Acetate	171-174	signal transducer and activator of transcription 1	Homo sapiens	82-87
14978237-3	2004	An association between c-Src and STAT1 was increased by IFN-gamma and TPA, indicating the direct phosphorylation of STAT1 by PKC-dependent c-Src activation.	Tetradecanoylphorbol Acetate	70-73	signal transducer and activator of transcription 1	Homo sapiens	33-38
14978237-3	2004	An association between c-Src and STAT1 was increased by IFN-gamma and TPA, indicating the direct phosphorylation of STAT1 by PKC-dependent c-Src activation.	Tetradecanoylphorbol Acetate	70-73	signal transducer and activator of transcription 1	Homo sapiens	116-121
14984736-9	2004	When HEK-293 cells expressed either PLD1 or PLD2, we observed elevated p38 phosphorylation in response to TPA stimulation.	Tetradecanoylphorbol Acetate	106-109	phospholipase D2	Homo sapiens	44-48
14623877-8	2004	Functional studies by constitutive expression of nm23-M2/NDPK-B in TPA susceptible JB6 Cl 41-5a and TPA-resistant JB6 Cl 30-7b preneoplastic epidermal cell lines showed a remarkable gene dosage-dependent increase in foci-forming activity, as well as an enhancement in the efficiency of neoplastic transformation of these cells in soft agar but no effect on proliferation in monolayer cultures.	Tetradecanoylphorbol Acetate	67-70	NME/NM23 nucleoside diphosphate kinase 2	Mus musculus	49-56
14623877-8	2004	Functional studies by constitutive expression of nm23-M2/NDPK-B in TPA susceptible JB6 Cl 41-5a and TPA-resistant JB6 Cl 30-7b preneoplastic epidermal cell lines showed a remarkable gene dosage-dependent increase in foci-forming activity, as well as an enhancement in the efficiency of neoplastic transformation of these cells in soft agar but no effect on proliferation in monolayer cultures.	Tetradecanoylphorbol Acetate	100-103	NME/NM23 nucleoside diphosphate kinase 2	Mus musculus	49-56
14698564-3	2004	Phorbol-12-myristate-13-acetate (PMA) potentiated (1 nM) TCDD-induced 7-ethoxyresorufin-O-deethylase (EROD) activity after 24h of treatment, and pre-treatment with (1 microM) of either a general PKC inhibitor (BisI) or PKCdelta-specific inhibitor (Rotterlin) abolished the potentiation indicating that activation of PKC enhances TCDD signal transduction.	Tetradecanoylphorbol Acetate	0-31	protein kinase C, delta	Mus musculus	219-227
14698564-3	2004	Phorbol-12-myristate-13-acetate (PMA) potentiated (1 nM) TCDD-induced 7-ethoxyresorufin-O-deethylase (EROD) activity after 24h of treatment, and pre-treatment with (1 microM) of either a general PKC inhibitor (BisI) or PKCdelta-specific inhibitor (Rotterlin) abolished the potentiation indicating that activation of PKC enhances TCDD signal transduction.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, delta	Mus musculus	219-227
14514518-5	2004	Forskolin (10 microM), a stimulator of adenylate cyclase and an activator of cAMP, opened BKCa channels in single FHR PASMC, which were blocked by the PKC activators phorbol 12-myristate 13-acetate (100 nM) and thymeleatoxin (100 nM).	Tetradecanoylphorbol Acetate	166-197	protein kinase C, gamma	Rattus norvegicus	151-154
15000485-2	2004	The polysaccharides (5, 10 and 25 microg ml(-1)) also suppressed 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity.	Tetradecanoylphorbol Acetate	65-101	ornithine decarboxylase	Glycine max	110-133
15193278-3	2004	12-O-tetradecanoylphorbol-13-acetate (TPA) could induce cell death in PC-12 cells that overexpressed Bcl-2, implicating protein kinase C (PKC) in Bcl-2 protection.	Tetradecanoylphorbol Acetate	0-36	protein kinase C, gamma	Rattus norvegicus	120-136
15193278-3	2004	12-O-tetradecanoylphorbol-13-acetate (TPA) could induce cell death in PC-12 cells that overexpressed Bcl-2, implicating protein kinase C (PKC) in Bcl-2 protection.	Tetradecanoylphorbol Acetate	0-36	protein kinase C, gamma	Rattus norvegicus	138-141
15193278-3	2004	12-O-tetradecanoylphorbol-13-acetate (TPA) could induce cell death in PC-12 cells that overexpressed Bcl-2, implicating protein kinase C (PKC) in Bcl-2 protection.	Tetradecanoylphorbol Acetate	38-41	protein kinase C, gamma	Rattus norvegicus	120-136
15193278-3	2004	12-O-tetradecanoylphorbol-13-acetate (TPA) could induce cell death in PC-12 cells that overexpressed Bcl-2, implicating protein kinase C (PKC) in Bcl-2 protection.	Tetradecanoylphorbol Acetate	38-41	protein kinase C, gamma	Rattus norvegicus	138-141
15193278-5	2004	High cytosolic and particulate protein levels of PKC delta were correlated with TPA-induced cell death suggesting that PKC delta positively regulated this cell death.	Tetradecanoylphorbol Acetate	80-83	protein kinase C, gamma	Rattus norvegicus	49-52
15193278-5	2004	High cytosolic and particulate protein levels of PKC delta were correlated with TPA-induced cell death suggesting that PKC delta positively regulated this cell death.	Tetradecanoylphorbol Acetate	80-83	protein kinase C, gamma	Rattus norvegicus	119-122
15193278-6	2004	However, substantial down-regulation of PKC by prolonged exposure to TPA did not reduce the frequency of TPA-induced cell death, raising the possibility that PKC delta did not regulate cell death alone.	Tetradecanoylphorbol Acetate	69-72	protein kinase C, gamma	Rattus norvegicus	40-43
14717982-5	2004	We found that alpha IIb beta 3 expressed in CMK cells with high GPIb expression was activated by a phorbor ester, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	114-139	cytidine/uridine monophosphate kinase 1	Homo sapiens	44-47
14717982-5	2004	We found that alpha IIb beta 3 expressed in CMK cells with high GPIb expression was activated by a phorbor ester, phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	141-144	cytidine/uridine monophosphate kinase 1	Homo sapiens	44-47
14717982-9	2004	We have also demonstrated that the ribavirin-treated CMK cells express PKC-alpha, -beta, -delta and -theta, and suggested that PKC-alpha and/or -beta appear to be responsible for PMA-induced activation of alpha IIb beta 3 in CMK cells.	Tetradecanoylphorbol Acetate	179-182	cytidine/uridine monophosphate kinase 1	Homo sapiens	53-56
14717982-9	2004	We have also demonstrated that the ribavirin-treated CMK cells express PKC-alpha, -beta, -delta and -theta, and suggested that PKC-alpha and/or -beta appear to be responsible for PMA-induced activation of alpha IIb beta 3 in CMK cells.	Tetradecanoylphorbol Acetate	179-182	cytidine/uridine monophosphate kinase 1	Homo sapiens	225-228
15111235-3	2004	RA/TPA treated cells exhibited the highest levels of tyrosine hydroxylase and DAT but lower levels of vesicular monoamine transporter.	Tetradecanoylphorbol Acetate	3-6	solute carrier family 6 member 3	Homo sapiens	78-81
15111235-5	2004	RA/TPA differentiated cells evidenced high sensitivity to the neurotoxic effects of MPP+ (0.03 to 3.0 mM), and the neurotoxic effects of MPP+ were blocked with the DAT inhibitor 1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine (GBR 12909).	Tetradecanoylphorbol Acetate	3-6	solute carrier family 6 member 3	Homo sapiens	164-167
15792026-5	2004	The intracellular expression of IL-4 and IFN-gamma in CD4+ or CD8+ cells after stimulation with ionomycin/PMA was estimated by flow cytometer (FACSCalibur, Becton Dickinson) and serum levels of both cytokines were assessed with ELISA (R &amp; D Systems) in all subjects.	Tetradecanoylphorbol Acetate	106-109	CD8a molecule	Homo sapiens	62-65
14644416-5	2003	In addition, gel shift assays and site-directed mutagenesis indicated that the CREB binding site at -143 is crucial for the TPA-induced expression of the hST3Gal V in HL-60 cells.	Tetradecanoylphorbol Acetate	124-127	cAMP responsive element binding protein 1	Homo sapiens	79-83
14639147-9	2003	Phorbol 12-myristate 13-acetate, a protein kinase C activator, also enhanced EAAT3 expression.	Tetradecanoylphorbol Acetate	0-31	solute carrier family 1 member 1	Rattus norvegicus	77-82
14639147-10	2003	The combination of 2% isoflurane and phorbol 12-myristate 13-acetate caused a higher level of EAAT3 expression than that induced by 2% isoflurane alone.	Tetradecanoylphorbol Acetate	37-68	solute carrier family 1 member 1	Rattus norvegicus	94-99
14578935-2	2003	Here, the significance of the phosphorylation of AANAT was studied using a semisynthetic enzyme in which a nonhydrolyzable phosphoserine/threonine mimetic, phosphonomethylenealanine (Pma), was incorporated at position 31 (AANAT-Pma31).	Tetradecanoylphorbol Acetate	183-186	aralkylamine N-acetyltransferase	Homo sapiens	49-54
13679379-11	2003	Chromatin immunoprecipitation assays revealed an enhanced recruitment of c-Jun, Jun-D, and Fra-2 to the endogenous fra-1 promoter upon TPA stimulation.	Tetradecanoylphorbol Acetate	135-138	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78
13679379-11	2003	Chromatin immunoprecipitation assays revealed an enhanced recruitment of c-Jun, Jun-D, and Fra-2 to the endogenous fra-1 promoter upon TPA stimulation.	Tetradecanoylphorbol Acetate	135-138	FOS like 2, AP-1 transcription factor subunit	Homo sapiens	91-96
13679379-12	2003	These results underscore the regulatory role of c-Jun, Jun-D, and Fra-2 in TPA-inducible fra-1 expression in HBE cells in vivo.	Tetradecanoylphorbol Acetate	75-78	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	48-53
13679379-12	2003	These results underscore the regulatory role of c-Jun, Jun-D, and Fra-2 in TPA-inducible fra-1 expression in HBE cells in vivo.	Tetradecanoylphorbol Acetate	75-78	FOS like 2, AP-1 transcription factor subunit	Homo sapiens	66-71
12960165-6	2003	The p38 MAPK inhibitor SB202190 and overexpression of dominant negative mutants of MAPK kinase 4 (MKK4), MKK6, and p38 inhibited the TPA-dependent induction of Prx I gene transcription.	Tetradecanoylphorbol Acetate	133-136	mitogen activated protein kinase kinase 4	Rattus norvegicus	83-96
12960165-6	2003	The p38 MAPK inhibitor SB202190 and overexpression of dominant negative mutants of MAPK kinase 4 (MKK4), MKK6, and p38 inhibited the TPA-dependent induction of Prx I gene transcription.	Tetradecanoylphorbol Acetate	133-136	mitogen activated protein kinase kinase 4	Rattus norvegicus	98-102
12967688-3	2003	The PKC activator, phorbol-12-myristate-13-acetate (PMA), enhanced acetylcholine (ACh) overflow in preparations obtained from normal animals.	Tetradecanoylphorbol Acetate	52-55	Prkca	Cavia porcellus	4-7
12967688-4	2003	The facilitatory effect of PMA was significantly reduced after prolonged exposure to the phorbol ester and by the PKC inhibitors, chelerythrine and calphostin C.	Tetradecanoylphorbol Acetate	27-30	Prkca	Cavia porcellus	114-117
12960243-4	2003	Immunoprecipitation experiments using plasma membranes of phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils revealed coimmunoprecipitation of PR3 with CD11b/CD18, indicating their location in the same complex.	Tetradecanoylphorbol Acetate	58-89	integrin subunit alpha M	Homo sapiens	162-167
14500826-6	2003	When losing the AP-1-dependent hMSH2 promoter activity, either by mutating the AP-1 binding sites of the hMSH2 promoter or by using a dominant negative c-Jun factor, the hMSH2 overexpression induced by TPA is abolished both in vitro and in vivo.	Tetradecanoylphorbol Acetate	202-205	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	16-20
14500826-6	2003	When losing the AP-1-dependent hMSH2 promoter activity, either by mutating the AP-1 binding sites of the hMSH2 promoter or by using a dominant negative c-Jun factor, the hMSH2 overexpression induced by TPA is abolished both in vitro and in vivo.	Tetradecanoylphorbol Acetate	202-205	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-83
14500826-6	2003	When losing the AP-1-dependent hMSH2 promoter activity, either by mutating the AP-1 binding sites of the hMSH2 promoter or by using a dominant negative c-Jun factor, the hMSH2 overexpression induced by TPA is abolished both in vitro and in vivo.	Tetradecanoylphorbol Acetate	202-205	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	152-157
12867426-5	2003	We also show that two TSC2 mutants derived from TSC patients are defective in repressing phorbol 12-myristate 13-acetate-induced 4E-BP1 phosphorylation.	Tetradecanoylphorbol Acetate	89-120	TSC complex subunit 2	Homo sapiens	22-26
12867426-7	2003	Phosphorylation of tuberin by phorbol 12-myristate 13-acetate was reduced by treatment of cells with either bisindolylmaleimide I or UO126, inhibitors of PKC and MAPK/MEK (MAPK/ERK kinase), respectively, but not by wortmannin (an inhibitor of PI3K).	Tetradecanoylphorbol Acetate	30-61	TSC complex subunit 2	Homo sapiens	19-26
12874194-7	2003	The PKC activator phorbol myristate acetate significantly increased vascular O2*- production, which was inhibited by superoxide dismutase, diphenyleneiodonium, chelerythrine, or removal of extracellular Ca2+.	Tetradecanoylphorbol Acetate	18-43	protein kinase C, alpha	Rattus norvegicus	4-7
12943527-9	2003	12-O-Tetradecanoylphorbol-13-acetate, a direct activator of protein kinase C, induced SAPK/JNK phosphorylation, which was suppressed by SP600125.	Tetradecanoylphorbol Acetate	0-36	mitogen-activated protein kinase 8	Mus musculus	91-94
12901873-5	2003	However, stimulation of cells with phorbol-12-myristate-13-acetate (PMA) increased peptide cleavage in a TACE-dependent manner.	Tetradecanoylphorbol Acetate	35-66	ADAM metallopeptidase domain 17	Homo sapiens	105-109
12901873-5	2003	However, stimulation of cells with phorbol-12-myristate-13-acetate (PMA) increased peptide cleavage in a TACE-dependent manner.	Tetradecanoylphorbol Acetate	68-71	ADAM metallopeptidase domain 17	Homo sapiens	105-109
12914440-2	2003	Complex 1, [(TPA)Fe(OTf)2], representative of Class A catalysts, forms a low-spin FeIII-OOH intermediate that gives rise to a high-valent FeV(=O)OH oxidant.	Tetradecanoylphorbol Acetate	13-16	POU class 2 homeobox 2	Homo sapiens	20-25
12810061-7	2003	PKC activation with 1 microM PMA for 30 min resulted in inhibition of the Ca(2+)-wave propagation, which could be overcome by PKC downregulation as in LE-RPE cells.	Tetradecanoylphorbol Acetate	29-32	protein kinase C, gamma	Rattus norvegicus	0-3
12810061-7	2003	PKC activation with 1 microM PMA for 30 min resulted in inhibition of the Ca(2+)-wave propagation, which could be overcome by PKC downregulation as in LE-RPE cells.	Tetradecanoylphorbol Acetate	29-32	protein kinase C, gamma	Rattus norvegicus	126-129
12766174-1	2003	Stimulation of intestinal fructose absorption by phorbol 12-myristate 13-acetate (PMA) results from rapid insertion of GLUT2 into the brush-border membrane and correlates with protein kinase C (PKC) betaII activation.	Tetradecanoylphorbol Acetate	49-80	solute carrier family 2 member 2	Homo sapiens	119-124
12766174-1	2003	Stimulation of intestinal fructose absorption by phorbol 12-myristate 13-acetate (PMA) results from rapid insertion of GLUT2 into the brush-border membrane and correlates with protein kinase C (PKC) betaII activation.	Tetradecanoylphorbol Acetate	82-85	solute carrier family 2 member 2	Homo sapiens	119-124
12883358-0	2003	CD44s adhesive function spontaneous and PMA-inducible CD44 cleavage are regulated at post-translational level in cells of melanocytic lineage.	Tetradecanoylphorbol Acetate	40-43	CD44 molecule (Indian blood group)	Homo sapiens	54-58
12588704-11	2003	PMA activates cPKCalpha and nPKCdelta at high affinity and stimulates a lower affinity PKC-independent pathway that leads to mucin secretion.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 13 member 2	Rattus norvegicus	125-130
12606313-2	2003	We previously showed that SERCA2 downregulation can be simulated in cultured neonatal rat ventricular myocytes (NRVM) by treatment with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	173-204	protein kinase C, alpha	Rattus norvegicus	158-161
12847680-6	2003	In phorbol myristate acetate/ionomycin-stimulated PBMCs, ATAC/Lptn expression was detected in CD8+ T cells and in a significantly increased proportion of CD4+,CD28- T cells from RA patients as compared with healthy controls.	Tetradecanoylphorbol Acetate	3-28	X-C motif chemokine ligand 1	Homo sapiens	57-61
12847680-6	2003	In phorbol myristate acetate/ionomycin-stimulated PBMCs, ATAC/Lptn expression was detected in CD8+ T cells and in a significantly increased proportion of CD4+,CD28- T cells from RA patients as compared with healthy controls.	Tetradecanoylphorbol Acetate	3-28	X-C motif chemokine ligand 1	Homo sapiens	62-66
12807762-2	2003	Treatment of cells with TPA results in the activation and subsequent depletion of the TPA-responsive protein kinase C (PKC) isoforms.	Tetradecanoylphorbol Acetate	24-27	protein kinase C, alpha	Rattus norvegicus	119-122
12807762-2	2003	Treatment of cells with TPA results in the activation and subsequent depletion of the TPA-responsive protein kinase C (PKC) isoforms.	Tetradecanoylphorbol Acetate	86-89	protein kinase C, alpha	Rattus norvegicus	119-122
12807762-6	2003	Prolonged TPA treatment induced down-regulation of PKCalpha, delta and epsilon and a reduction in the total PKC activity, which was associated with recovery of GJIC.	Tetradecanoylphorbol Acetate	10-13	protein kinase C, alpha	Rattus norvegicus	51-59
12807762-6	2003	Prolonged TPA treatment induced down-regulation of PKCalpha, delta and epsilon and a reduction in the total PKC activity, which was associated with recovery of GJIC.	Tetradecanoylphorbol Acetate	10-13	protein kinase C, alpha	Rattus norvegicus	51-54
12807762-7	2003	Co-treatment of IAR20 cells with TPA and the proteasomal inhibitor MG132 suppressed down-regulation of PKCalpha, delta and epsilon and caused prolonged PKC activity.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, alpha	Rattus norvegicus	103-111
12807762-7	2003	Co-treatment of IAR20 cells with TPA and the proteasomal inhibitor MG132 suppressed down-regulation of PKCalpha, delta and epsilon and caused prolonged PKC activity.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, alpha	Rattus norvegicus	103-106
12807762-9	2003	The general PKC inhibitor GF109203X reversed the effect of MG132, indicating that the prolonged TPA-induced inhibition of GJIC caused by MG132 was due to the prolonged PKC activity.	Tetradecanoylphorbol Acetate	96-99	protein kinase C, alpha	Rattus norvegicus	12-15
12807762-9	2003	The general PKC inhibitor GF109203X reversed the effect of MG132, indicating that the prolonged TPA-induced inhibition of GJIC caused by MG132 was due to the prolonged PKC activity.	Tetradecanoylphorbol Acetate	96-99	protein kinase C, alpha	Rattus norvegicus	168-171
12807762-10	2003	These results indicate that proteasomal degradation of PKC is one mechanism by which the recovery of GJIC after TPA treatment is regulated.	Tetradecanoylphorbol Acetate	112-115	protein kinase C, alpha	Rattus norvegicus	55-58
12702734-7	2003	Western blot analysis demonstrated that both PMA treatment and incubation with the myristoylated PKCbetaC2-4 pseudosubstrate resulted in more glucose transporter (GLUT)-1 but not GLUT-4 at the plasma membrane.	Tetradecanoylphorbol Acetate	45-48	solute carrier family 2 member 1	Homo sapiens	142-170
14515793-7	2003	Gelatin zymography results showed that MMP-9 expression in U937 cells increased significantly after exposed to PMA at 1 x 10(-8) mol.L-1 (P &lt; 0.001); MMP-9 expression induced with phorbol myristate acetate(PMA) was inhibited by dexamethasone at 1 x 10(-9), 1 x 10(-7) and 1 x 10(-5) mol.L-1, indomethacin at 1 x 10(-6) and 1 x 10(-5) mol.L-1 and resveratrol at 1 x 10(-6) and 1 x 10(-5) mol.L-1.	Tetradecanoylphorbol Acetate	111-114	matrix metallopeptidase 9	Homo sapiens	39-44
14515793-7	2003	Gelatin zymography results showed that MMP-9 expression in U937 cells increased significantly after exposed to PMA at 1 x 10(-8) mol.L-1 (P &lt; 0.001); MMP-9 expression induced with phorbol myristate acetate(PMA) was inhibited by dexamethasone at 1 x 10(-9), 1 x 10(-7) and 1 x 10(-5) mol.L-1, indomethacin at 1 x 10(-6) and 1 x 10(-5) mol.L-1 and resveratrol at 1 x 10(-6) and 1 x 10(-5) mol.L-1.	Tetradecanoylphorbol Acetate	111-114	matrix metallopeptidase 9	Homo sapiens	153-158
14515793-7	2003	Gelatin zymography results showed that MMP-9 expression in U937 cells increased significantly after exposed to PMA at 1 x 10(-8) mol.L-1 (P &lt; 0.001); MMP-9 expression induced with phorbol myristate acetate(PMA) was inhibited by dexamethasone at 1 x 10(-9), 1 x 10(-7) and 1 x 10(-5) mol.L-1, indomethacin at 1 x 10(-6) and 1 x 10(-5) mol.L-1 and resveratrol at 1 x 10(-6) and 1 x 10(-5) mol.L-1.	Tetradecanoylphorbol Acetate	183-208	matrix metallopeptidase 9	Homo sapiens	39-44
14515793-7	2003	Gelatin zymography results showed that MMP-9 expression in U937 cells increased significantly after exposed to PMA at 1 x 10(-8) mol.L-1 (P &lt; 0.001); MMP-9 expression induced with phorbol myristate acetate(PMA) was inhibited by dexamethasone at 1 x 10(-9), 1 x 10(-7) and 1 x 10(-5) mol.L-1, indomethacin at 1 x 10(-6) and 1 x 10(-5) mol.L-1 and resveratrol at 1 x 10(-6) and 1 x 10(-5) mol.L-1.	Tetradecanoylphorbol Acetate	183-208	matrix metallopeptidase 9	Homo sapiens	153-158
14515793-7	2003	Gelatin zymography results showed that MMP-9 expression in U937 cells increased significantly after exposed to PMA at 1 x 10(-8) mol.L-1 (P &lt; 0.001); MMP-9 expression induced with phorbol myristate acetate(PMA) was inhibited by dexamethasone at 1 x 10(-9), 1 x 10(-7) and 1 x 10(-5) mol.L-1, indomethacin at 1 x 10(-6) and 1 x 10(-5) mol.L-1 and resveratrol at 1 x 10(-6) and 1 x 10(-5) mol.L-1.	Tetradecanoylphorbol Acetate	209-212	matrix metallopeptidase 9	Homo sapiens	39-44
14515793-7	2003	Gelatin zymography results showed that MMP-9 expression in U937 cells increased significantly after exposed to PMA at 1 x 10(-8) mol.L-1 (P &lt; 0.001); MMP-9 expression induced with phorbol myristate acetate(PMA) was inhibited by dexamethasone at 1 x 10(-9), 1 x 10(-7) and 1 x 10(-5) mol.L-1, indomethacin at 1 x 10(-6) and 1 x 10(-5) mol.L-1 and resveratrol at 1 x 10(-6) and 1 x 10(-5) mol.L-1.	Tetradecanoylphorbol Acetate	209-212	matrix metallopeptidase 9	Homo sapiens	153-158
12850286-2	2003	The transcription rate of Hx was found to be increased 11-fold by the calcium ionophore A23187, 25-fold by the calcium ionophore ionomycin, and 4-5-fold by phorbol 12-myristate 13-acetate (PMA) in serum-starved H4IIE rat hepatoma cells.	Tetradecanoylphorbol Acetate	156-187	hemopexin	Rattus norvegicus	26-28
12850286-2	2003	The transcription rate of Hx was found to be increased 11-fold by the calcium ionophore A23187, 25-fold by the calcium ionophore ionomycin, and 4-5-fold by phorbol 12-myristate 13-acetate (PMA) in serum-starved H4IIE rat hepatoma cells.	Tetradecanoylphorbol Acetate	189-192	hemopexin	Rattus norvegicus	26-28
12782152-2	2003	In these cells, the PLD activity was significantly increased by porcine platelet-derived growth factor (PDGF-BB), phorbol 12-myristate 13-acetate (PMA), and epidermal growth factor (EGF).	Tetradecanoylphorbol Acetate	114-145	Phospholipase D	Drosophila melanogaster	20-23
12562561-2	2003	An activator of classical and novel isoforms of PKC, phorbol 12-myristate-13-acetate (PMA; 100 nM), inhibited CAT-1-mediated l-arginine transport in PAEC after a 1-h treatment and activated l-arginine uptake after an 18-h treatment of cells.	Tetradecanoylphorbol Acetate	53-84	solute carrier family 7 member 1	Homo sapiens	110-115
12562561-2	2003	An activator of classical and novel isoforms of PKC, phorbol 12-myristate-13-acetate (PMA; 100 nM), inhibited CAT-1-mediated l-arginine transport in PAEC after a 1-h treatment and activated l-arginine uptake after an 18-h treatment of cells.	Tetradecanoylphorbol Acetate	86-89	solute carrier family 7 member 1	Homo sapiens	110-115
12646577-17	2003	Incadronate markedly enhanced the phosphorylation of Raf-1, MEK1/2, and p44/p42 MAPK induced by PGF2 alpha or 12-O-tetradecanoylphorbol-13-acetate, a PKC activator.	Tetradecanoylphorbol Acetate	110-146	v-raf-leukemia viral oncogene 1	Mus musculus	53-58
12621060-10	2003	Moreover, 12-O-tetradecanoylphorbol 13-acetate induced the irreversible translocation of whole rat-DGKgamma and its C1B deletion mutant, not the C1A deletion mutant, from the cytoplasm to the plasma membrane of CHO-K1 cells.	Tetradecanoylphorbol Acetate	10-46	diacylglycerol kinase, gamma	Rattus norvegicus	99-107
12621060-11	2003	These results indicate that 12-O-tetradecanoylphorbol 13-acetate binds to C1A of DGKgamma to cause its translocation.	Tetradecanoylphorbol Acetate	28-64	diacylglycerol kinase, gamma	Rattus norvegicus	81-89
12522006-1	2003	Monocytic differentiation of 32DPKCdelta cells in response to activation of protein kinase C delta (PKCdelta) by phorbol 12-myristate 13-acetate (PMA) was inhibited by exogenous CCAAT/enhancer binding protein alpha-estradiol receptor (C/EBPalpha-ER), which impeded morphologic maturation and induction of macrosialin mRNA.	Tetradecanoylphorbol Acetate	146-149	CD68 molecule	Homo sapiens	305-316
12640676-9	2003	Additionally, some TPA-induced genes, such as Sprr1A, Saa3, JunB, Il4ralpha, Gp38, RalGDS and Slpi exhibit high basal level in advanced stages of skin carcinogenesis, suggesting that at least a subgroup of the identified TPA-regulated genes may contribute to tumour progression and metastasis.	Tetradecanoylphorbol Acetate	19-22	interleukin 4 receptor, alpha	Mus musculus	66-75
12640676-9	2003	Additionally, some TPA-induced genes, such as Sprr1A, Saa3, JunB, Il4ralpha, Gp38, RalGDS and Slpi exhibit high basal level in advanced stages of skin carcinogenesis, suggesting that at least a subgroup of the identified TPA-regulated genes may contribute to tumour progression and metastasis.	Tetradecanoylphorbol Acetate	19-22	ral guanine nucleotide dissociation stimulator	Mus musculus	83-89
12640676-9	2003	Additionally, some TPA-induced genes, such as Sprr1A, Saa3, JunB, Il4ralpha, Gp38, RalGDS and Slpi exhibit high basal level in advanced stages of skin carcinogenesis, suggesting that at least a subgroup of the identified TPA-regulated genes may contribute to tumour progression and metastasis.	Tetradecanoylphorbol Acetate	19-22	secretory leukocyte peptidase inhibitor	Mus musculus	94-98
12639716-3	2003	In the present study we show that treatment of intact mouse islets and RINm5F cells with protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) or protein kinase A (PKA) activator forskolin promoted insulin secretion with no changes of [Ca(2+)](i).	Tetradecanoylphorbol Acetate	122-153	protein kinase C, alpha	Rattus norvegicus	107-110
12639716-3	2003	In the present study we show that treatment of intact mouse islets and RINm5F cells with protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) or protein kinase A (PKA) activator forskolin promoted insulin secretion with no changes of [Ca(2+)](i).	Tetradecanoylphorbol Acetate	155-158	protein kinase C, alpha	Rattus norvegicus	107-110
12639716-6	2003	PMA treatment caused translocation of PKC-alpha and PKC- epsilon from cytosol to membrane, implying that selectively PKC-alpha and PKC- epsilon isoforms might be important for insulin secretion.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	38-47
12639716-6	2003	PMA treatment caused translocation of PKC-alpha and PKC- epsilon from cytosol to membrane, implying that selectively PKC-alpha and PKC- epsilon isoforms might be important for insulin secretion.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	117-126
14668059-1	2003	We examined the effect of the protein kinase C activator phorbol-12-myristate-13-acetate (PMA) on the human eosinophil adhesion molecule phenotype and attachment to VCAM-1 via alpha4 and alphad integrins under static and flow conditions.	Tetradecanoylphorbol Acetate	90-93	immunoglobulin binding protein 1	Homo sapiens	176-182
12748306-8	2003	Neutralization of TNF-alpha protein with cV1q in vivo for 0-15 weeks of promotion significantly decreased skin tumor development after 9,10-dimethyl-1,2-benzanthracene/TPA treatment.	Tetradecanoylphorbol Acetate	168-171	endogenous ecotropic MuLV 1	Mus musculus	41-44
12706838-3	2003	Here, we investigated the transcriptional machinery required for T cell receptor (TCR) activation-dependent induction of 4-1BB expression in CD3-CEM cells treated with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	168-193	TNF receptor superfamily member 9	Homo sapiens	121-126
12647303-12	2003	Treatment with phorbol 12-myristate-13-acetate (PMA), under conditions that caused downregulation of protein kinase Calpha (PKCalpha), decreased nuclear FGF-2.	Tetradecanoylphorbol Acetate	15-46	protein kinase C alpha type	Cricetulus griseus	101-122
12647303-12	2003	Treatment with phorbol 12-myristate-13-acetate (PMA), under conditions that caused downregulation of protein kinase Calpha (PKCalpha), decreased nuclear FGF-2.	Tetradecanoylphorbol Acetate	48-51	protein kinase C alpha type	Cricetulus griseus	101-122
12551925-4	2003	RKIP Ser-153 phosphorylation by PKC either in vitro or in response to 12-O-tetradecanoylphorbol-13-acetate or epidermal growth factor causes release of RKIP from Raf-1, whereas mutant RKIP (S153V or S153E) remains bound.	Tetradecanoylphorbol Acetate	70-106	phosphatidylethanolamine binding protein 1	Homo sapiens	0-4
12551925-4	2003	RKIP Ser-153 phosphorylation by PKC either in vitro or in response to 12-O-tetradecanoylphorbol-13-acetate or epidermal growth factor causes release of RKIP from Raf-1, whereas mutant RKIP (S153V or S153E) remains bound.	Tetradecanoylphorbol Acetate	70-106	phosphatidylethanolamine binding protein 1	Homo sapiens	152-156
12551925-4	2003	RKIP Ser-153 phosphorylation by PKC either in vitro or in response to 12-O-tetradecanoylphorbol-13-acetate or epidermal growth factor causes release of RKIP from Raf-1, whereas mutant RKIP (S153V or S153E) remains bound.	Tetradecanoylphorbol Acetate	70-106	phosphatidylethanolamine binding protein 1	Homo sapiens	152-156
12606436-7	2003	The treatment of BESCs with 12-O-tetradecanoylphorbol 13-acetate resulted in a significant increase in the level of TIMP-1 but a significant decrease in the level of TIMP-2 in the stromal cells.	Tetradecanoylphorbol Acetate	28-64	TIMP metallopeptidase inhibitor 2	Bos taurus	166-172
12623071-8	2003	12-O-Tetradecanoyl phorbol 13-acetate suppressed expression of CYP2P2 and CYP2P3 in killifish intestine; fasting itself suppressed expression of CYP2P2/3 but not CYP2P1.	Tetradecanoylphorbol Acetate	0-37	cytochrome P450 2J6-like	Fundulus heteroclitus	74-80
12629514-5	2003	We demonstrate that the intramembranous cleavage of CD44 induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment or mechanical scraping is blocked by gamma-secretase inhibitors in U251MG cells and that this cleavage is also inhibited in PS-deficient mouse embryonic fibroblasts.	Tetradecanoylphorbol Acetate	68-104	CD44 molecule (Indian blood group)	Homo sapiens	52-56
12629514-5	2003	We demonstrate that the intramembranous cleavage of CD44 induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment or mechanical scraping is blocked by gamma-secretase inhibitors in U251MG cells and that this cleavage is also inhibited in PS-deficient mouse embryonic fibroblasts.	Tetradecanoylphorbol Acetate	106-109	CD44 molecule (Indian blood group)	Homo sapiens	52-56
12629514-6	2003	Furthermore, we showed that PS1 is redistributed to ruffling areas of the plasma membrane similarly to CD44 after TPA treatment, supporting our biochemical observation that PS1 is involved in the intramembranous cleavage of CD44.	Tetradecanoylphorbol Acetate	114-117	CD44 molecule (Indian blood group)	Homo sapiens	103-107
12629514-6	2003	Furthermore, we showed that PS1 is redistributed to ruffling areas of the plasma membrane similarly to CD44 after TPA treatment, supporting our biochemical observation that PS1 is involved in the intramembranous cleavage of CD44.	Tetradecanoylphorbol Acetate	114-117	CD44 molecule (Indian blood group)	Homo sapiens	224-228
12606037-3	2003	These results support a role for ARF in PMA-stimulated MMP-9 secretion.	Tetradecanoylphorbol Acetate	40-43	matrix metallopeptidase 9	Homo sapiens	55-60
12569366-6	2003	We also show that this processing, which does not occur in the TrkC catalytic counterpart, is upregulated by NT-3 and upon treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	157-193	neurotrophic receptor tyrosine kinase 3	Homo sapiens	63-67
12526024-8	2003	Basal expression of SNAP-25 was also modified by the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate, but not by Go6976, a PKC-alpha inhibitor, suggesting that the Ca(2+)-insensitive PKC-epsilon isoform control basal expression of SNAP-25 in these cells.	Tetradecanoylphorbol Acetate	87-118	protein kinase C epsilon	Bos taurus	71-74
12519122-6	2003	Using northern blots, we show that in DMEL-2 cells, TPA significantly increases the messenger ribonucleic acid (mRNA) levels of the tyrosinase gene family (tyrosinase, Tyrp1 and Dct) and the expression of Mitf.	Tetradecanoylphorbol Acetate	52-55	tyrosinase-related protein 1	Mus musculus	168-173
12519122-6	2003	Using northern blots, we show that in DMEL-2 cells, TPA significantly increases the messenger ribonucleic acid (mRNA) levels of the tyrosinase gene family (tyrosinase, Tyrp1 and Dct) and the expression of Mitf.	Tetradecanoylphorbol Acetate	52-55	dopachrome tautomerase	Mus musculus	178-181
12519122-7	2003	Western blots demonstrate that in these TPA-treated cells there is a concomitant increase in Tyr, Tyrp1 and glycosylated Dct protein levels.	Tetradecanoylphorbol Acetate	40-43	tyrosinase-related protein 1	Mus musculus	98-103
12519122-7	2003	Western blots demonstrate that in these TPA-treated cells there is a concomitant increase in Tyr, Tyrp1 and glycosylated Dct protein levels.	Tetradecanoylphorbol Acetate	40-43	dopachrome tautomerase	Mus musculus	121-124
12505729-6	2003	RESULTS: PD analyses suggested that in NHS samples containing CsA+SRL (n=5), (1) PMA-Ionomycin-stimulated T-cell expression of intracellular IL-2, TNF-alpha, and IFN-gamma was inhibited by CsA, and minimally by SRL, and (2) the two agents inhibited pokeweed mitogen (PWM)-stimulated B-cell expression of CD54 and CD95, but not CD86 (ICAM-1, Fas antigen, and B7.2), synergistically.	Tetradecanoylphorbol Acetate	81-84	intercellular adhesion molecule 1	Homo sapiens	304-308
12465042-6	2003	In addition, activation of PKC by phorbol myristoyl acetate (PMA) activated Erk1/2 with concomitant increase in MMP-9 production.	Tetradecanoylphorbol Acetate	61-64	matrix metallopeptidase 9	Rattus norvegicus	112-117
12757023-7	2003	One of the mechanisms by which retinoids inhibit promotion of mouse skin tumor formation involves their property to inhibit the induction of ornithine decarboxylase by the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	201-237	ornithine decarboxylase, structural 1	Mus musculus	141-164
15000837-1	2003	In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.	Tetradecanoylphorbol Acetate	107-132	Cd4 molecule	Rattus norvegicus	60-63
15000837-1	2003	In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.	Tetradecanoylphorbol Acetate	107-132	Cd4 molecule	Rattus norvegicus	224-227
15000837-1	2003	In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.	Tetradecanoylphorbol Acetate	134-137	Cd4 molecule	Rattus norvegicus	60-63
15000837-1	2003	In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.	Tetradecanoylphorbol Acetate	134-137	Cd4 molecule	Rattus norvegicus	224-227
12568314-0	2002	Inhibition of CD4 expression by antisense oligonucleotides in PMA-treated lymphocytes.	Tetradecanoylphorbol Acetate	62-65	Cd4 molecule	Rattus norvegicus	14-17
12568314-5	2002	CD4 resynthesis was stimulated by treatment with phorbol 12-myristate 13-acetate (PMA) at the same time as the incubations with the ODN.	Tetradecanoylphorbol Acetate	49-80	Cd4 molecule	Rattus norvegicus	0-3
12568314-5	2002	CD4 resynthesis was stimulated by treatment with phorbol 12-myristate 13-acetate (PMA) at the same time as the incubations with the ODN.	Tetradecanoylphorbol Acetate	82-85	Cd4 molecule	Rattus norvegicus	0-3
12489106-1	2002	The dominant negative c-jun TAM-67 has been shown to inhibit tumor promotion induced by 12-O-tetradecanoylphorbol-13-acetate and okadaic acid (OA).	Tetradecanoylphorbol Acetate	88-124	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	22-27
12485318-9	2002	All the patient groups expressed (spontaneously and following stimulation with phorbol myristate acetate and ionomycin together with mite-extract proteins) greater amounts of CD69 and CD54 than did control subjects.	Tetradecanoylphorbol Acetate	79-104	intercellular adhesion molecule 1	Homo sapiens	184-188
12429713-0	2002	Role of CD80, CD86, and CTLA4 on mouse CD4(+) T lymphocytes in enhancing cell-cycle progression and survival after activation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	131-134	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	24-29
12429713-0	2002	Role of CD80, CD86, and CTLA4 on mouse CD4(+) T lymphocytes in enhancing cell-cycle progression and survival after activation with PMA and ionomycin.	Tetradecanoylphorbol Acetate	131-134	CD4 antigen	Mus musculus	39-42
12429713-3	2002	We show that CD80, CD86, and CTLA4 are induced on purified CD4(+) T cells after in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, and they play an essential role for proliferation and survival.	Tetradecanoylphorbol Acetate	105-136	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	29-34
12429713-3	2002	We show that CD80, CD86, and CTLA4 are induced on purified CD4(+) T cells after in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, and they play an essential role for proliferation and survival.	Tetradecanoylphorbol Acetate	105-136	CD4 antigen	Mus musculus	59-62
12429713-3	2002	We show that CD80, CD86, and CTLA4 are induced on purified CD4(+) T cells after in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, and they play an essential role for proliferation and survival.	Tetradecanoylphorbol Acetate	138-141	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	29-34
12429713-3	2002	We show that CD80, CD86, and CTLA4 are induced on purified CD4(+) T cells after in vitro activation with phorbol 12-myristate 13-acetate (PMA) and ionomycin, and they play an essential role for proliferation and survival.	Tetradecanoylphorbol Acetate	138-141	CD4 antigen	Mus musculus	59-62
12429713-9	2002	This study reveals a functional role for CD80, CD86, and CTLA4 on CD4(+) T lymphocytes and sheds light on the mechanisms by which these molecules enhance activation and survival with PMA and ionomycin.	Tetradecanoylphorbol Acetate	183-186	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	57-62
12429713-9	2002	This study reveals a functional role for CD80, CD86, and CTLA4 on CD4(+) T lymphocytes and sheds light on the mechanisms by which these molecules enhance activation and survival with PMA and ionomycin.	Tetradecanoylphorbol Acetate	183-186	CD4 antigen	Mus musculus	66-69
12138159-8	2002	Release of soluble KIM-1 is enhanced by activating the cells with phorbol 12-myristate 13-acetate and can be inhibited with two metalloproteinase inhibitors, BB-94 (Batimastat) and GM6001 (Ilomastat), suggesting that the cleavage is mediated by a metalloproteinase.	Tetradecanoylphorbol Acetate	66-97	hepatitis A virus cellular receptor 1	Homo sapiens	19-24
12151388-12	2002	Furthermore, K-Ras, the isoform previously shown to bind to calmodulin, is the only one activated by TPA when calmodulin is inhibited.	Tetradecanoylphorbol Acetate	101-104	calmodulin 2	Mus musculus	60-70
12151388-12	2002	Furthermore, K-Ras, the isoform previously shown to bind to calmodulin, is the only one activated by TPA when calmodulin is inhibited.	Tetradecanoylphorbol Acetate	101-104	calmodulin 2	Mus musculus	110-120
12151388-14	2002	In vitro experiments showed that the phosphorylation of K-Ras by PKC was inhibited by calmodulin, suggesting that calmodulin-dependent modulation of K-Ras phosphorylation by PKC could be the mechanism underlying K-Ras activation in fibroblasts treated with TPA plus W13.	Tetradecanoylphorbol Acetate	257-260	calmodulin 2	Mus musculus	86-96
12151388-14	2002	In vitro experiments showed that the phosphorylation of K-Ras by PKC was inhibited by calmodulin, suggesting that calmodulin-dependent modulation of K-Ras phosphorylation by PKC could be the mechanism underlying K-Ras activation in fibroblasts treated with TPA plus W13.	Tetradecanoylphorbol Acetate	257-260	calmodulin 2	Mus musculus	114-124
12438101-4	2002	Pretreating the cells with phorbol 12-myristate 13-acetate (PMA) to downregulate PKC activity did not affect the nicotine-induced glucose transport, but completely attenuated that activated by muscarine, suggesting that Ach activation of transport involved both diacylglycerol-independent (PKCzeta) and diacylglycerol-dependent PKCs (PKCalpha/PKCepsilon).	Tetradecanoylphorbol Acetate	27-58	protein kinase C alpha	Bos taurus	81-84
12438101-4	2002	Pretreating the cells with phorbol 12-myristate 13-acetate (PMA) to downregulate PKC activity did not affect the nicotine-induced glucose transport, but completely attenuated that activated by muscarine, suggesting that Ach activation of transport involved both diacylglycerol-independent (PKCzeta) and diacylglycerol-dependent PKCs (PKCalpha/PKCepsilon).	Tetradecanoylphorbol Acetate	27-58	protein kinase C alpha	Bos taurus	334-342
12438101-4	2002	Pretreating the cells with phorbol 12-myristate 13-acetate (PMA) to downregulate PKC activity did not affect the nicotine-induced glucose transport, but completely attenuated that activated by muscarine, suggesting that Ach activation of transport involved both diacylglycerol-independent (PKCzeta) and diacylglycerol-dependent PKCs (PKCalpha/PKCepsilon).	Tetradecanoylphorbol Acetate	27-58	protein kinase C epsilon	Bos taurus	343-353
12438101-4	2002	Pretreating the cells with phorbol 12-myristate 13-acetate (PMA) to downregulate PKC activity did not affect the nicotine-induced glucose transport, but completely attenuated that activated by muscarine, suggesting that Ach activation of transport involved both diacylglycerol-independent (PKCzeta) and diacylglycerol-dependent PKCs (PKCalpha/PKCepsilon).	Tetradecanoylphorbol Acetate	60-63	protein kinase C alpha	Bos taurus	81-84
12438101-4	2002	Pretreating the cells with phorbol 12-myristate 13-acetate (PMA) to downregulate PKC activity did not affect the nicotine-induced glucose transport, but completely attenuated that activated by muscarine, suggesting that Ach activation of transport involved both diacylglycerol-independent (PKCzeta) and diacylglycerol-dependent PKCs (PKCalpha/PKCepsilon).	Tetradecanoylphorbol Acetate	60-63	protein kinase C alpha	Bos taurus	334-342
12438101-4	2002	Pretreating the cells with phorbol 12-myristate 13-acetate (PMA) to downregulate PKC activity did not affect the nicotine-induced glucose transport, but completely attenuated that activated by muscarine, suggesting that Ach activation of transport involved both diacylglycerol-independent (PKCzeta) and diacylglycerol-dependent PKCs (PKCalpha/PKCepsilon).	Tetradecanoylphorbol Acetate	60-63	protein kinase C epsilon	Bos taurus	343-353
12270146-1	2002	A human megakaryoblastic cell line, CMK, was treated with 12-o-tetradecanoylphorbol-13-acetate (TPA) for differentiation-induction.	Tetradecanoylphorbol Acetate	58-94	cytidine/uridine monophosphate kinase 1	Homo sapiens	36-39
12270146-1	2002	A human megakaryoblastic cell line, CMK, was treated with 12-o-tetradecanoylphorbol-13-acetate (TPA) for differentiation-induction.	Tetradecanoylphorbol Acetate	96-99	cytidine/uridine monophosphate kinase 1	Homo sapiens	36-39
12270146-2	2002	We examined TPA-induced activation of the MEK1-ERK1/2 pathway in the 100,000g Triton X-insoluble fraction of CMK cells as the membrane skeleton and researched the relation of the MEK1-ERK1/2 activation with integrin expression.	Tetradecanoylphorbol Acetate	12-15	cytidine/uridine monophosphate kinase 1	Homo sapiens	109-112
12072243-5	2002	In contrast, stimulation by Con A or PMA/ionomycin induced efficient replication but only low level IFN-gamma production which was not enhanced by the presence of IL-12.	Tetradecanoylphorbol Acetate	37-40	interferon gamma	Bos taurus	100-109
12213569-7	2002	Distinct from serum factors and the tumor promoter TPA-induced MAPKs, which resulted in transcriptional activation of ELK or c-JUN, TCDD-stimulated MAPKs were critical for the induction of AHR-dependent gene transcription and CYP1A1 expression.	Tetradecanoylphorbol Acetate	51-54	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	125-130
12176893-5	2002	When PBMCs were stimulated with phorbol myristate acetate/ionomycin or with anti-CD3/anti-CD28, the accumulation of LTalpha both at mRNA and protein levels was markedly inhibited by CsA.	Tetradecanoylphorbol Acetate	32-57	lymphotoxin alpha	Homo sapiens	116-123
12225365-2	2002	Phorbol 12-myristate 13-acetate (PMA) caused time- and concentration-dependent adhesion of AML cells to plated bovine serum albumin (BSA), which was blocked by anti-CD11b or anti-CD18 monoclonal antibodies (mAb) directed against beta2-integrin.	Tetradecanoylphorbol Acetate	0-31	integrin subunit alpha M	Homo sapiens	165-170
12225365-2	2002	Phorbol 12-myristate 13-acetate (PMA) caused time- and concentration-dependent adhesion of AML cells to plated bovine serum albumin (BSA), which was blocked by anti-CD11b or anti-CD18 monoclonal antibodies (mAb) directed against beta2-integrin.	Tetradecanoylphorbol Acetate	33-36	integrin subunit alpha M	Homo sapiens	165-170
12225365-4	2002	Inhibition of cytosolic phospholipase A2 (cPLA2) with trifluoromethyl ketone or methyl arachidonyl fluorophosphonate also blocked PMA-induced cell adhesion.	Tetradecanoylphorbol Acetate	130-133	phospholipase A2 group IVA	Homo sapiens	14-40
12225365-4	2002	Inhibition of cytosolic phospholipase A2 (cPLA2) with trifluoromethyl ketone or methyl arachidonyl fluorophosphonate also blocked PMA-induced cell adhesion.	Tetradecanoylphorbol Acetate	130-133	phospholipase A2 group IVA	Homo sapiens	42-47
12242039-4	2002	CgA promoter reporter plasmid experiments showed that gastrin, epidermal growth factor, and phorbol 12-myristate 13-acetate, induce upregulation of CgA after 24 h. By RT-PCR, it was found that AR42J expresses all of the five subtypes of the somatostatin (SST) receptor (SSTR) family, except SSTR4.	Tetradecanoylphorbol Acetate	92-123	somatostatin receptor 4	Rattus norvegicus	291-296
12133875-7	2002	Intracellular expression of IFN-gamma, IL-2, and IL-4 was detected in CD4(+) and CD8(+) T cells after stimulation with phorbol 12-myristate 13-acetate and ionomycin.	Tetradecanoylphorbol Acetate	119-150	CD8a molecule	Homo sapiens	81-84
12167345-3	2002	After stimulation with phorbol 12-myristate 13-acetate and ionomycin, an increase in the percentage of IFN-gamma and IL-4 producing CD8(+) T cells was observed during aging.	Tetradecanoylphorbol Acetate	23-54	CD8a molecule	Homo sapiens	132-135
12453641-10	2002	The present study focused on the glypican-1, syndecan-1 and syndecan-4 mRNA expression and regulation under PKC activation by the phorbol myristate acetate (PMA) in 10-30 day-old Sertoli cells.	Tetradecanoylphorbol Acetate	130-155	protein kinase C, alpha	Rattus norvegicus	108-111
12453641-10	2002	The present study focused on the glypican-1, syndecan-1 and syndecan-4 mRNA expression and regulation under PKC activation by the phorbol myristate acetate (PMA) in 10-30 day-old Sertoli cells.	Tetradecanoylphorbol Acetate	157-160	protein kinase C, alpha	Rattus norvegicus	108-111
12061815-2	2002	Exposure of U937 cells to 1 mM SB and 1 nM PMA (24 h) markedly induced caspase activation and apoptosis, events accompanied by impaired differentiation induction (e.g., reduced plastic adherence and diminished expression of CD11b) as well as reduced clonogenic survival.	Tetradecanoylphorbol Acetate	43-46	integrin subunit alpha M	Homo sapiens	224-229
11925438-7	2002	In addition, we show that tyrosine phosphorylation of p190RhoGAP is increased upon 12-O-tetradecanoylphorbol-13-acetate stimulation, directly linking Src activation to a decrease in RhoA activity.	Tetradecanoylphorbol Acetate	83-119	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	150-153
11925438-7	2002	In addition, we show that tyrosine phosphorylation of p190RhoGAP is increased upon 12-O-tetradecanoylphorbol-13-acetate stimulation, directly linking Src activation to a decrease in RhoA activity.	Tetradecanoylphorbol Acetate	83-119	ras homolog family member A	Rattus norvegicus	182-186
12071971-6	2002	In addition, 4beta-phorbol 12-myristate 13-acetate up-regulates human (I)SHP-1 transcript expression in SKOV3 cells (an ovarian cancer cell line).	Tetradecanoylphorbol Acetate	13-50	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	73-78
12054494-4	2002	Even if each site differs from the canonical TPA responsive element for one nucleotide, only the first two AP-1 consensus sequences seemed to be functional since allowed DNA-binding activity of nuclear proteins after HGF treatment.	Tetradecanoylphorbol Acetate	45-48	hepatocyte growth factor	Mus musculus	217-220
11980644-1	2002	Treatment with retinoic acid (RA) or carnosol, two structurally unrelated compounds with anticancer properties, inhibited phorbol ester (PMA)-mediated induction of activator protein-1 (AP-1) activity and cyclooxygenase-2 (COX-2) expression in human mammary epithelial cells.	Tetradecanoylphorbol Acetate	137-140	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	164-183
11980644-1	2002	Treatment with retinoic acid (RA) or carnosol, two structurally unrelated compounds with anticancer properties, inhibited phorbol ester (PMA)-mediated induction of activator protein-1 (AP-1) activity and cyclooxygenase-2 (COX-2) expression in human mammary epithelial cells.	Tetradecanoylphorbol Acetate	137-140	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	185-189
11980644-2	2002	The induction of COX-2 transcription by PMA was mediated by increased binding of AP-1 to the cyclic AMP response element (CRE) of the COX-2 promoter.	Tetradecanoylphorbol Acetate	40-43	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	81-85
11980644-10	2002	Overexpressing c-Jun but not CBP/p300 reversed the suppressive effect of carnosol on PMA-mediated stimulation of COX-2 promoter activity.	Tetradecanoylphorbol Acetate	85-88	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-20
11960919-3	2002	In short-term experiments, expression of the ODCdn protein product was induced in the epidermis within 24 h after application of the tumor promoter tetradecanoyl phorbol acetate (TPA) to the skin, and ODC activity in the epidermis of K6/ODCdn mice was reduced by at least 75% compared with littermate controls.	Tetradecanoylphorbol Acetate	148-177	ornithine decarboxylase, structural 1	Mus musculus	45-48
11960919-3	2002	In short-term experiments, expression of the ODCdn protein product was induced in the epidermis within 24 h after application of the tumor promoter tetradecanoyl phorbol acetate (TPA) to the skin, and ODC activity in the epidermis of K6/ODCdn mice was reduced by at least 75% compared with littermate controls.	Tetradecanoylphorbol Acetate	179-182	ornithine decarboxylase, structural 1	Mus musculus	45-48
11960919-7	2002	Analysis of epidermis following multiple TPA applications revealed a dramatic spike in ODC activity in both K6/ODCdn mice and non-transgenic mice after six applications, and western blot analysis suggested a stabilization of endogenous wild-type ODC in K6/ODCdn transgenic mice.	Tetradecanoylphorbol Acetate	41-44	ornithine decarboxylase, structural 1	Mus musculus	87-90
11960919-7	2002	Analysis of epidermis following multiple TPA applications revealed a dramatic spike in ODC activity in both K6/ODCdn mice and non-transgenic mice after six applications, and western blot analysis suggested a stabilization of endogenous wild-type ODC in K6/ODCdn transgenic mice.	Tetradecanoylphorbol Acetate	41-44	ornithine decarboxylase, structural 1	Mus musculus	111-114
11956247-4	2002	12-O-tetradecanoylphorbol-13-acetate, but not 1,25(OH)(2)D(3), induced differentiation of bone marrow-committed myeloid stem cells from VDR KO mice to monocytes/macrophages.	Tetradecanoylphorbol Acetate	0-36	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	136-139
11781325-4	2002	Human alpha(1a)AR-mediated inositol phosphate signaling is acutely desensitized in response to both agonist and phorbol 12-myristate 13-acetate (PMA) exposure.	Tetradecanoylphorbol Acetate	112-143	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	6-14
11781325-4	2002	Human alpha(1a)AR-mediated inositol phosphate signaling is acutely desensitized in response to both agonist and phorbol 12-myristate 13-acetate (PMA) exposure.	Tetradecanoylphorbol Acetate	145-148	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	6-14
11781325-5	2002	Concurrent with desensitization, alpha(1a)ARs in (32)P(i)-labeled cells are rapidly phosphorylated in response to both NE and PMA stimulation.	Tetradecanoylphorbol Acetate	126-129	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	33-41
11781325-6	2002	Despite the ability of PKC to desensitize alpha(1a)ARs when directly activated with PMA, inhibitors of PKC have no effect on agonist-mediated desensitization.	Tetradecanoylphorbol Acetate	84-87	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	42-50
11873046-11	2002	PKC activation with phorbol myristate acetate attenuated isoproterenol-stimulated cAMP production.	Tetradecanoylphorbol Acetate	20-45	protein kinase C, alpha	Rattus norvegicus	0-3
11950097-3	2002	DNA binding of AP-1 to the target 12-O-tetradecanoylphorbol-13-acetate response element sequence was maximally induced 1-3 h after irradiation.	Tetradecanoylphorbol Acetate	34-70	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-19
11840288-8	2002	Not surprisingly, lovastatin also induces G0/G1 arrest and apoptosis in Bcr/Abl-transformed cells, however, TPA protects cells from both apoptosis and G0/G1 arrest caused by lovastatin.	Tetradecanoylphorbol Acetate	108-111	BCR activator of RhoGEF and GTPase	Homo sapiens	72-75
11779150-5	2002	High glucose and the PKC stimulator, phorbol 12-myristate 13-acetate (PMA) induced activator protein-1 (AP-1)-dependent transcriptional activity and expression of VEGF.	Tetradecanoylphorbol Acetate	37-68	vascular endothelial growth factor A	Mus musculus	163-167
11779150-5	2002	High glucose and the PKC stimulator, phorbol 12-myristate 13-acetate (PMA) induced activator protein-1 (AP-1)-dependent transcriptional activity and expression of VEGF.	Tetradecanoylphorbol Acetate	70-73	vascular endothelial growth factor A	Mus musculus	163-167
12201673-5	2002	In parallel with suppression of tumor promotion, topically applied yakuchinone A and B markedly inhibited TPA-induced epidermal ODC activity and ODC mRNA expression.	Tetradecanoylphorbol Acetate	106-109	ornithine decarboxylase, structural 1	Mus musculus	128-131
12201673-5	2002	In parallel with suppression of tumor promotion, topically applied yakuchinone A and B markedly inhibited TPA-induced epidermal ODC activity and ODC mRNA expression.	Tetradecanoylphorbol Acetate	106-109	ornithine decarboxylase, structural 1	Mus musculus	145-148
11716547-4	2001	We have previously demonstrated that the tumor promoter TPA can induce MMP-9 expression via a third signaling cascade, the p38 pathway.	Tetradecanoylphorbol Acetate	56-59	matrix metallopeptidase 9	Homo sapiens	71-76
11716547-5	2001	Considering that TPA is a potent activator of AP-1, we hypothesized that this transcription factor might also be required for p38 pathway-dependent MMP-9 regulation.	Tetradecanoylphorbol Acetate	17-20	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	46-50
11716547-5	2001	Considering that TPA is a potent activator of AP-1, we hypothesized that this transcription factor might also be required for p38 pathway-dependent MMP-9 regulation.	Tetradecanoylphorbol Acetate	17-20	matrix metallopeptidase 9	Homo sapiens	148-153
11696436-7	2001	Lptn mRNA was found to be up-regulated on stimulation with phorbol-12-myristate-13-acetate and concanavalin A in T cells isolated from peripheral blood, which could be prevented by dexamethasone, cyclosporine A, and FK506.	Tetradecanoylphorbol Acetate	59-90	X-C motif chemokine ligand 1	Homo sapiens	0-4
11641060-8	2001	These results suggest that TPA and Ca2+-switch induced BPAG1 translocation to membrane fractions possibly mediated by PKC-activation.	Tetradecanoylphorbol Acetate	27-30	dystonin	Homo sapiens	55-60
11641060-9	2001	Furthermore, whereas TPA affects the redistribution of BPAG1 among their pools without inducing their synthesis, Ca2+-switch induces both membrane translocation and synthesis of BPAG1, suggesting involvement of signaling other than PKC pathways in control of BPAG1 synthesis.	Tetradecanoylphorbol Acetate	21-24	dystonin	Homo sapiens	55-60
11641439-2	2001	Phorbol 12-myristate 13-acetate (PMA) challenge of HASMC rapidly activated PDE4D5 through a process ablated by the mitogen-activated protein kinase kinase inhibitor PD98059.	Tetradecanoylphorbol Acetate	0-31	phosphodiesterase 4D	Homo sapiens	75-80
11641439-2	2001	Phorbol 12-myristate 13-acetate (PMA) challenge of HASMC rapidly activated PDE4D5 through a process ablated by the mitogen-activated protein kinase kinase inhibitor PD98059.	Tetradecanoylphorbol Acetate	33-36	phosphodiesterase 4D	Homo sapiens	75-80
11641439-3	2001	PMA elicited an inhibitory effect on PDE4D5 activity in HASMC treated with the cyclooxygenase (COX) inhibitor indomethacin, the COX-2 selective inhibitor NS-398, the phospholipase A(2) inhibitor quinacrine, and the cAMP-dependent protein kinase A (PKA) inhibitor H89.	Tetradecanoylphorbol Acetate	0-3	phosphodiesterase 4D	Homo sapiens	37-42
11533251-4	2001	Rottlerin blocks phorbol ester (phorbol myristate acetate [PMA])- or B-cell receptor (BCR)-mediated NF-kappaB and c-Jun N-terminal kinase (JNK) activation in primary B and T cells to a similar extent, suggesting that novel PKCs are positive regulators of signaling in hematopoietic cells.	Tetradecanoylphorbol Acetate	32-57	mitogen-activated protein kinase 8	Mus musculus	139-142
11533251-4	2001	Rottlerin blocks phorbol ester (phorbol myristate acetate [PMA])- or B-cell receptor (BCR)-mediated NF-kappaB and c-Jun N-terminal kinase (JNK) activation in primary B and T cells to a similar extent, suggesting that novel PKCs are positive regulators of signaling in hematopoietic cells.	Tetradecanoylphorbol Acetate	59-62	mitogen-activated protein kinase 8	Mus musculus	114-137
11533251-4	2001	Rottlerin blocks phorbol ester (phorbol myristate acetate [PMA])- or B-cell receptor (BCR)-mediated NF-kappaB and c-Jun N-terminal kinase (JNK) activation in primary B and T cells to a similar extent, suggesting that novel PKCs are positive regulators of signaling in hematopoietic cells.	Tetradecanoylphorbol Acetate	59-62	mitogen-activated protein kinase 8	Mus musculus	139-142
11533251-9	2001	In addition, PMA-induced activation of the mitogen-activated protein kinase JNK is blocked in 1.3E2 cells, suggesting that an upstream component common to both pathways is either missing or mutated.	Tetradecanoylphorbol Acetate	13-16	mitogen-activated protein kinase 8	Mus musculus	76-79
11564869-5	2001	Primary lymphocytes from HePTP(-/-) mice show enhanced activation of extracellular stimulus-regulated kinase (ERK) after both phorbol myristate acetate (PMA) and anti-CD3-mediated T-cell receptor (TCR) stimulation, suggesting a true physiological relationship between these two molecules.	Tetradecanoylphorbol Acetate	126-151	protein tyrosine phosphatase, non-receptor type 7	Mus musculus	25-30
11564869-5	2001	Primary lymphocytes from HePTP(-/-) mice show enhanced activation of extracellular stimulus-regulated kinase (ERK) after both phorbol myristate acetate (PMA) and anti-CD3-mediated T-cell receptor (TCR) stimulation, suggesting a true physiological relationship between these two molecules.	Tetradecanoylphorbol Acetate	153-156	protein tyrosine phosphatase, non-receptor type 7	Mus musculus	25-30
11572997-6	2001	We also observed a 62% and 74% reduction by avicins in H-ras mutations at codon 61 in the DMBA and DMBA/TPA models, respectively, as well as a significant inhibition of the modified DNA base formation (8-OH-dG) in both protocols.	Tetradecanoylphorbol Acetate	104-107	Harvey rat sarcoma virus oncogene	Mus musculus	55-60
11549266-7	2001	Moreover, PMA (phorbol myristate acetate), PKC (protein kinase C) activator, protected U937 cells from okadaic acid-induced apoptosis, abrogated okadaic acid-induced caspase 3 activation, and specifically inhibited downregulation of XIAP (X-linked inhibitor of apoptosis) by okadaic acid.	Tetradecanoylphorbol Acetate	10-13	X-linked inhibitor of apoptosis	Homo sapiens	239-270
11549266-7	2001	Moreover, PMA (phorbol myristate acetate), PKC (protein kinase C) activator, protected U937 cells from okadaic acid-induced apoptosis, abrogated okadaic acid-induced caspase 3 activation, and specifically inhibited downregulation of XIAP (X-linked inhibitor of apoptosis) by okadaic acid.	Tetradecanoylphorbol Acetate	15-40	X-linked inhibitor of apoptosis	Homo sapiens	233-237
11549266-7	2001	Moreover, PMA (phorbol myristate acetate), PKC (protein kinase C) activator, protected U937 cells from okadaic acid-induced apoptosis, abrogated okadaic acid-induced caspase 3 activation, and specifically inhibited downregulation of XIAP (X-linked inhibitor of apoptosis) by okadaic acid.	Tetradecanoylphorbol Acetate	15-40	X-linked inhibitor of apoptosis	Homo sapiens	239-270
11504680-8	2001	Downregulation of PKC with phorbol 12-myristate 13-acetate rescued the FK506-mediated inhibition of recovery, which was consistent with the finding that the thrombin-induced phosphorylation of PKC-alpha was reduced during the recovery phase.	Tetradecanoylphorbol Acetate	27-58	protein kinase C alpha	Bos taurus	18-21
11504680-8	2001	Downregulation of PKC with phorbol 12-myristate 13-acetate rescued the FK506-mediated inhibition of recovery, which was consistent with the finding that the thrombin-induced phosphorylation of PKC-alpha was reduced during the recovery phase.	Tetradecanoylphorbol Acetate	27-58	coagulation factor II, thrombin	Bos taurus	157-165
11504680-8	2001	Downregulation of PKC with phorbol 12-myristate 13-acetate rescued the FK506-mediated inhibition of recovery, which was consistent with the finding that the thrombin-induced phosphorylation of PKC-alpha was reduced during the recovery phase.	Tetradecanoylphorbol Acetate	27-58	protein kinase C alpha	Bos taurus	193-202
11543740-4	2001	RESULTS: Receptor for activated C kinase-1 was located exclusively in membranes and, in control brains, the levels of RACK1 that coimmunoprecipitated with most PKC isozymes were increased by stimulation with the PKC activator, phorbol 12-myristate, 13-acetate (PMA).	Tetradecanoylphorbol Acetate	261-264	receptor for activated C kinase 1	Homo sapiens	9-42
11543740-4	2001	RESULTS: Receptor for activated C kinase-1 was located exclusively in membranes and, in control brains, the levels of RACK1 that coimmunoprecipitated with most PKC isozymes were increased by stimulation with the PKC activator, phorbol 12-myristate, 13-acetate (PMA).	Tetradecanoylphorbol Acetate	261-264	receptor for activated C kinase 1	Homo sapiens	118-123
11530022-6	2001	It was further demonstrated that annexin V was secreted by isolated alveolar type II cells from rats and that the secretion was stimulated by the addition of phorbol ester (PMA), a potent stimulator of surfactant secretion.	Tetradecanoylphorbol Acetate	173-176	annexin A5	Rattus norvegicus	33-42
11413129-4	2001	Phorbol 12-myristate 13-acetate also strongly activated both SAP kinases and IKK isoforms, suggesting the potential for a protein kinase C-mediated regulatory mechanism underlying the effects of trypsin.	Tetradecanoylphorbol Acetate	0-31	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	77-80
11526503-5	2001	Bryostatin 1 selectively prevented TPA-induced PKCdelta-downregulation and reversed TPA-induced release from contact-inhibition arguing for a role of PKCdelta in contact-inhibition.	Tetradecanoylphorbol Acetate	35-38	protein kinase C, delta	Mus musculus	47-55
11479211-4	2001	TPA- or EGF-induced phosphorylation of c-Jun, but not extracellular signal-regulated kinases or p38 kinases, was also blocked by the compounds, indicating that c-Jun N-terminal kinases were critical in mediating TPA- or EGF-induced AP-1 activity and subsequent cell transformation in JB6 cells.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-44
11479211-4	2001	TPA- or EGF-induced phosphorylation of c-Jun, but not extracellular signal-regulated kinases or p38 kinases, was also blocked by the compounds, indicating that c-Jun N-terminal kinases were critical in mediating TPA- or EGF-induced AP-1 activity and subsequent cell transformation in JB6 cells.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	160-165
11479211-4	2001	TPA- or EGF-induced phosphorylation of c-Jun, but not extracellular signal-regulated kinases or p38 kinases, was also blocked by the compounds, indicating that c-Jun N-terminal kinases were critical in mediating TPA- or EGF-induced AP-1 activity and subsequent cell transformation in JB6 cells.	Tetradecanoylphorbol Acetate	212-215	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-44
11479211-4	2001	TPA- or EGF-induced phosphorylation of c-Jun, but not extracellular signal-regulated kinases or p38 kinases, was also blocked by the compounds, indicating that c-Jun N-terminal kinases were critical in mediating TPA- or EGF-induced AP-1 activity and subsequent cell transformation in JB6 cells.	Tetradecanoylphorbol Acetate	212-215	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	160-165
11461775-2	2001	The metal-vitamin complex was shown able to strongly potentiate AP-1 binding as induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	91-122	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	64-68
11461775-2	2001	The metal-vitamin complex was shown able to strongly potentiate AP-1 binding as induced by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	124-127	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	64-68
11461775-7	2001	In fact, protein synthesis inhibitor cycloheximide (CHX) prevented the stimulation of AP-1 nuclear binding due to PMA and ascorbate plus PMA.	Tetradecanoylphorbol Acetate	114-117	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-90
11461775-7	2001	In fact, protein synthesis inhibitor cycloheximide (CHX) prevented the stimulation of AP-1 nuclear binding due to PMA and ascorbate plus PMA.	Tetradecanoylphorbol Acetate	137-140	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	86-90
11457772-4	2001	Anti-CD54 monoclonal antibody attenuated leukocyte aggregation and superoxide production of rGM-CSF- or PMA-stimulated neutrophils and PMA-stimulated eosinophils.	Tetradecanoylphorbol Acetate	104-107	intercellular adhesion molecule 1	Homo sapiens	5-9
11457772-4	2001	Anti-CD54 monoclonal antibody attenuated leukocyte aggregation and superoxide production of rGM-CSF- or PMA-stimulated neutrophils and PMA-stimulated eosinophils.	Tetradecanoylphorbol Acetate	135-138	intercellular adhesion molecule 1	Homo sapiens	5-9
11591891-11	2001	Selective expression of RIZ1 was also induced by 12-O-tetradecanoyl-phorbol-13-acetate in the U937 and HL60 cell lines and by 1,25-dihydroxyvitamin D(3) only in HL60 cells.	Tetradecanoylphorbol Acetate	49-86	PR/SET domain 2	Homo sapiens	24-28
11591891-15	2001	CONCLUSIONS: The correlation between the selective expression of RIZ1 induced by retinoic acid, 12-O-tetradecanoyl-phorbol-13-acetate, or 1,25-dihydroxyvitamin D(3) and differentiation suggested that RIZ protein was involved in myeloid cell differentiation induced by these agents.	Tetradecanoylphorbol Acetate	96-133	PR/SET domain 2	Homo sapiens	65-69
11591891-15	2001	CONCLUSIONS: The correlation between the selective expression of RIZ1 induced by retinoic acid, 12-O-tetradecanoyl-phorbol-13-acetate, or 1,25-dihydroxyvitamin D(3) and differentiation suggested that RIZ protein was involved in myeloid cell differentiation induced by these agents.	Tetradecanoylphorbol Acetate	96-133	PR/SET domain 2	Homo sapiens	65-68
11342553-3	2001	Serum, lysophosphatidic acid, platelet-derived growth factor, and phorbol 12-myristate 13-acetate (PMA) each activated transcription of a stably integrated SRF reporter gene dependent on functional RhoA GTPase.	Tetradecanoylphorbol Acetate	66-97	serum response factor	Homo sapiens	156-159
11342553-3	2001	Serum, lysophosphatidic acid, platelet-derived growth factor, and phorbol 12-myristate 13-acetate (PMA) each activated transcription of a stably integrated SRF reporter gene dependent on functional RhoA GTPase.	Tetradecanoylphorbol Acetate	99-102	serum response factor	Homo sapiens	156-159
11749832-8	2001	Interestingly, TPA-induced c-fos/c-jun mRNA expression in endothelial cells was also inhibited by triptolide.	Tetradecanoylphorbol Acetate	15-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-32
11749832-8	2001	Interestingly, TPA-induced c-fos/c-jun mRNA expression in endothelial cells was also inhibited by triptolide.	Tetradecanoylphorbol Acetate	15-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	33-38
11463743-3	2001	We identified the novel KRE-M9 element, further downstream to the previously reported TPA responsive element in the MMP-9 promoter, and both of these two elements were shown to be important for MMP-9 transcription and Ca(2+) induction.	Tetradecanoylphorbol Acetate	86-89	matrix metallopeptidase 9	Homo sapiens	116-121
11463743-3	2001	We identified the novel KRE-M9 element, further downstream to the previously reported TPA responsive element in the MMP-9 promoter, and both of these two elements were shown to be important for MMP-9 transcription and Ca(2+) induction.	Tetradecanoylphorbol Acetate	86-89	matrix metallopeptidase 9	Homo sapiens	194-199
11432790-6	2001	After stimulation with phorbol-12-myristate-13-acetate (PMA), U937 cells exhibited the ability to adhere to laminin and LBP specifically inhibited this adhesion.	Tetradecanoylphorbol Acetate	23-54	lipopolysaccharide binding protein	Homo sapiens	120-123
11432790-6	2001	After stimulation with phorbol-12-myristate-13-acetate (PMA), U937 cells exhibited the ability to adhere to laminin and LBP specifically inhibited this adhesion.	Tetradecanoylphorbol Acetate	56-59	lipopolysaccharide binding protein	Homo sapiens	120-123
11408617-3	2001	Pretreatment of HeLa cells with resveratrol inhibited the transcription of AP-1 reporter gene by UVC and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	105-136	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-79
11408617-3	2001	Pretreatment of HeLa cells with resveratrol inhibited the transcription of AP-1 reporter gene by UVC and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	138-141	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-79
11304537-11	2001	In a second experiment, NS3 inhibited the oxidative burst induced by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	69-100	KRAS proto-oncogene, GTPase	Homo sapiens	24-27
11285196-9	2001	JNK activity was decreased at 1 and 6 h but increased at 4 h (P&lt;0.05) post-TPA treatment.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 8	Mus musculus	0-3
11394533-7	2001	Activation of E+ cells with phorbol-12-myristate-13-acetate (PMA) enhanced CH11 expression uniformly, whereas activation with phytohemagglutinin (PHA) selectively down-regulated expression of the antigen on the CD8+ subset.	Tetradecanoylphorbol Acetate	61-64	CD8a molecule	Homo sapiens	211-214
11241357-4	2001	In the presence of DF, PMA-induced upregulation of the cyclin dependent kinase inhibitor (CDKI), p21(WAF1/CIP1), was blocked and its expression could be restored in the presence of DF by supplementation with ferric citrate.	Tetradecanoylphorbol Acetate	23-26	cyclin dependent kinase inhibitor 3	Homo sapiens	55-88
11241357-4	2001	In the presence of DF, PMA-induced upregulation of the cyclin dependent kinase inhibitor (CDKI), p21(WAF1/CIP1), was blocked and its expression could be restored in the presence of DF by supplementation with ferric citrate.	Tetradecanoylphorbol Acetate	23-26	cyclin dependent kinase inhibitor 3	Homo sapiens	90-94
11254678-4	2001	PMA also induces accumulation of cyclin D3-cdk4 complexes in B-2 cells; however, these complexes do not phosphorylate pRb.	Tetradecanoylphorbol Acetate	0-3	immunoglobulin kappa variable 5-2	Homo sapiens	61-64
11330879-4	2001	RESULTS: Both phorbol-12-myristate-13-acetate (PMA), a PKC activator and A23187, a calcium ionophore, significantly increased adrenomedullin mRNA expression and secretion from the myocytes.	Tetradecanoylphorbol Acetate	14-45	protein kinase C, gamma	Rattus norvegicus	55-58
11330879-4	2001	RESULTS: Both phorbol-12-myristate-13-acetate (PMA), a PKC activator and A23187, a calcium ionophore, significantly increased adrenomedullin mRNA expression and secretion from the myocytes.	Tetradecanoylphorbol Acetate	47-50	protein kinase C, gamma	Rattus norvegicus	55-58
11330879-5	2001	The induction of adrenomedullin secretion by PMA was abolished by H7, a PKC inhibitor, and by downregulation of PKC induced by pre-incubation with PMA.	Tetradecanoylphorbol Acetate	45-48	protein kinase C, gamma	Rattus norvegicus	72-75
11330879-5	2001	The induction of adrenomedullin secretion by PMA was abolished by H7, a PKC inhibitor, and by downregulation of PKC induced by pre-incubation with PMA.	Tetradecanoylphorbol Acetate	147-150	protein kinase C, gamma	Rattus norvegicus	112-115
11207216-6	2001	The regulation of PGHS-2 mRNA and protein was studied in primary cultures of bovine uterine stromal cells stimulated with phorbol 12-myristate 13-acetate (PMA; 100 nM).	Tetradecanoylphorbol Acetate	122-153	prostaglandin-endoperoxide synthase 2	Bos taurus	18-24
11207216-6	2001	The regulation of PGHS-2 mRNA and protein was studied in primary cultures of bovine uterine stromal cells stimulated with phorbol 12-myristate 13-acetate (PMA; 100 nM).	Tetradecanoylphorbol Acetate	155-158	prostaglandin-endoperoxide synthase 2	Bos taurus	18-24
11207216-7	2001	Northern and Western blot analyses reveal a marked induction in PGHS-2 transcript (4.0 kilobases) and protein (M(r) = 72 000) after 3-12 h of PMA stimulation (P &lt; 0.05).	Tetradecanoylphorbol Acetate	142-145	prostaglandin-endoperoxide synthase 2	Bos taurus	64-70
11282458-2	2001	Application of 80 nM phorbol 12-myristate 13-acetate (PMA), a PKC-activating phorbol ester, had little effect on glucose (15 mM)-induced insulin secretion from intact rat islets.	Tetradecanoylphorbol Acetate	21-52	protein kinase C, gamma	Rattus norvegicus	62-65
11282458-2	2001	Application of 80 nM phorbol 12-myristate 13-acetate (PMA), a PKC-activating phorbol ester, had little effect on glucose (15 mM)-induced insulin secretion from intact rat islets.	Tetradecanoylphorbol Acetate	54-57	protein kinase C, gamma	Rattus norvegicus	62-65
11282458-3	2001	In islets treated with bisindolylmaleimide (BIM), a PKC inhibitor, PMA significantly reduced the glucose-induced insulin secretion.	Tetradecanoylphorbol Acetate	67-70	protein kinase C, gamma	Rattus norvegicus	52-55
11181529-4	2001	We previously observed that phorbol ester (PMA)-induced activation of protein kinase C (PKC) causes metalloprotease-mediated GHR proteolysis and GHBP shedding in human IM-9 lymphocytes.	Tetradecanoylphorbol Acetate	43-46	growth hormone receptor	Homo sapiens	125-128
11181529-4	2001	We previously observed that phorbol ester (PMA)-induced activation of protein kinase C (PKC) causes metalloprotease-mediated GHR proteolysis and GHBP shedding in human IM-9 lymphocytes.	Tetradecanoylphorbol Acetate	43-46	growth hormone receptor	Homo sapiens	145-149
11288761-7	2001	Addition of phorbol 12-myristate 13-acetate to the cultures rendered the cells resistant to dexamethasone with regard to proliferation and IL-10 and IFN-gamma production, but not to IL-2 and TNF-alpha production in both patients and controls.	Tetradecanoylphorbol Acetate	12-43	interleukin 10	Homo sapiens	139-144
11272178-4	2001	The general applicability of the approach is exemplified by doxycyclin-(Tet-On) and phorbol 12-myristate 13-acetate-induced (c-fos) promoter activation, with green fluorescent protein (GFP) and red fluorescent protein (DsRed) as semiquantitative and immediate reporters, of transcription activation.	Tetradecanoylphorbol Acetate	84-115	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	125-130
11156944-4	2001	However, it is not fully understood how PMA activates TACE and induces ectodomain shedding.	Tetradecanoylphorbol Acetate	40-43	ADAM metallopeptidase domain 17	Homo sapiens	54-58
11156944-7	2001	Exogenous H2O2 mimicked PMA-induced enhancement of ectodomain shedding, and H2O2-induced shedding was blocked by TAPI, a TACE inhibitor.	Tetradecanoylphorbol Acetate	24-27	ADAM metallopeptidase domain 17	Homo sapiens	121-125
11160957-4	2001	METHODS: The authors assessed endogenous CREB phosphorylation in a CLS fibroblast line by Western blotting and found impaired CREB phosphorylation in response to stimulation by EGF and the protein kinase C (PKC) agonist phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	220-251	cAMP responsive element binding protein 1	Homo sapiens	41-45
11160957-4	2001	METHODS: The authors assessed endogenous CREB phosphorylation in a CLS fibroblast line by Western blotting and found impaired CREB phosphorylation in response to stimulation by EGF and the protein kinase C (PKC) agonist phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	220-251	cAMP responsive element binding protein 1	Homo sapiens	126-130
11160957-4	2001	METHODS: The authors assessed endogenous CREB phosphorylation in a CLS fibroblast line by Western blotting and found impaired CREB phosphorylation in response to stimulation by EGF and the protein kinase C (PKC) agonist phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	253-256	cAMP responsive element binding protein 1	Homo sapiens	41-45
11160957-4	2001	METHODS: The authors assessed endogenous CREB phosphorylation in a CLS fibroblast line by Western blotting and found impaired CREB phosphorylation in response to stimulation by EGF and the protein kinase C (PKC) agonist phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	253-256	cAMP responsive element binding protein 1	Homo sapiens	126-130
11050091-8	2001	PMA could also activate a signaling pathway involving MEK1/ERK2/c-Jun-dependent uPA expression.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	64-69
11368020-10	2001	Additional analysis revealed that TPA-induced apoptosis was associated with the downregulation of the anti-apoptotic proteins Bcl-x and Mcl-1 and dependent on the activity of the transcription factor Jun.	Tetradecanoylphorbol Acetate	34-37	MCL1 apoptosis regulator, BCL2 family member	Sus scrofa	136-141
11299737-4	2001	NAC inhibited TPA-enhanced invasion dose-dependently.	Tetradecanoylphorbol Acetate	14-17	X-linked Kx blood group	Homo sapiens	0-3
11299737-5	2001	TPA increased the MMP-9 production by T24 cells without altering expression of TIMP-1 gene, while NAC suppressed TPA-enhanced production of MMP-9.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	18-23
11299737-5	2001	TPA increased the MMP-9 production by T24 cells without altering expression of TIMP-1 gene, while NAC suppressed TPA-enhanced production of MMP-9.	Tetradecanoylphorbol Acetate	113-116	X-linked Kx blood group	Homo sapiens	98-101
11299737-5	2001	TPA increased the MMP-9 production by T24 cells without altering expression of TIMP-1 gene, while NAC suppressed TPA-enhanced production of MMP-9.	Tetradecanoylphorbol Acetate	113-116	matrix metallopeptidase 9	Homo sapiens	140-145
11115401-6	2001	In cells incubated with or without the Ca(2+) ionophore ionomycin plus PMA, cPLA(2) co-localized with plasma membrane, endoplasmic reticulum and nuclei, but not with mitochondria or Golgi.	Tetradecanoylphorbol Acetate	71-74	phospholipase A2 group IVA	Homo sapiens	76-83
16352050-9	2001	Under normoxic conditions, activation of PKC by phorbol-12-myristate-13-acetate (PMA; 100 nmol/L) markedly increased HO-1 gene expression, while inhibition of PKC activity by calphostin C (100 nmol/L) blocked hypoxia-induced HO-1 gene expression in cardiac myocytes.	Tetradecanoylphorbol Acetate	48-79	heme oxygenase 1	Rattus norvegicus	117-121
16352050-9	2001	Under normoxic conditions, activation of PKC by phorbol-12-myristate-13-acetate (PMA; 100 nmol/L) markedly increased HO-1 gene expression, while inhibition of PKC activity by calphostin C (100 nmol/L) blocked hypoxia-induced HO-1 gene expression in cardiac myocytes.	Tetradecanoylphorbol Acetate	48-79	heme oxygenase 1	Rattus norvegicus	225-229
16352050-9	2001	Under normoxic conditions, activation of PKC by phorbol-12-myristate-13-acetate (PMA; 100 nmol/L) markedly increased HO-1 gene expression, while inhibition of PKC activity by calphostin C (100 nmol/L) blocked hypoxia-induced HO-1 gene expression in cardiac myocytes.	Tetradecanoylphorbol Acetate	81-84	heme oxygenase 1	Rattus norvegicus	117-121
16352050-9	2001	Under normoxic conditions, activation of PKC by phorbol-12-myristate-13-acetate (PMA; 100 nmol/L) markedly increased HO-1 gene expression, while inhibition of PKC activity by calphostin C (100 nmol/L) blocked hypoxia-induced HO-1 gene expression in cardiac myocytes.	Tetradecanoylphorbol Acetate	81-84	heme oxygenase 1	Rattus norvegicus	225-229
11200061-0	2001	Transcriptional activation of the gp91phox NADPH oxidase subunit by TPA in HL-60 cells.	Tetradecanoylphorbol Acetate	68-71	cytochrome b-245 beta chain	Homo sapiens	34-42
11200061-5	2001	In cells treated with TPA, the burst in ROS at 48 h was preceded by accumulation at 12 h of gp91phox (8.8-fold) and p47phox mRNA (threefold), whereas untreated cells contained steady-state levels of both transcripts.	Tetradecanoylphorbol Acetate	22-25	cytochrome b-245 beta chain	Homo sapiens	92-100
11200061-5	2001	In cells treated with TPA, the burst in ROS at 48 h was preceded by accumulation at 12 h of gp91phox (8.8-fold) and p47phox mRNA (threefold), whereas untreated cells contained steady-state levels of both transcripts.	Tetradecanoylphorbol Acetate	22-25	neutrophil cytosolic factor 1	Homo sapiens	116-123
11200061-7	2001	In transient transfections, luciferase reporter activity directed from a 1.5-kb gp91phox promoter fragment was enhanced threefold upon treatment with TPA for 24 h. We conclude that TPA can commit HL-60 cells to differentiation and elicit transcription from the proximal gp91phox promoter.	Tetradecanoylphorbol Acetate	150-153	cytochrome b-245 beta chain	Homo sapiens	80-88
11200061-7	2001	In transient transfections, luciferase reporter activity directed from a 1.5-kb gp91phox promoter fragment was enhanced threefold upon treatment with TPA for 24 h. We conclude that TPA can commit HL-60 cells to differentiation and elicit transcription from the proximal gp91phox promoter.	Tetradecanoylphorbol Acetate	150-153	cytochrome b-245 beta chain	Homo sapiens	270-278
11200061-7	2001	In transient transfections, luciferase reporter activity directed from a 1.5-kb gp91phox promoter fragment was enhanced threefold upon treatment with TPA for 24 h. We conclude that TPA can commit HL-60 cells to differentiation and elicit transcription from the proximal gp91phox promoter.	Tetradecanoylphorbol Acetate	181-184	cytochrome b-245 beta chain	Homo sapiens	80-88
11200061-7	2001	In transient transfections, luciferase reporter activity directed from a 1.5-kb gp91phox promoter fragment was enhanced threefold upon treatment with TPA for 24 h. We conclude that TPA can commit HL-60 cells to differentiation and elicit transcription from the proximal gp91phox promoter.	Tetradecanoylphorbol Acetate	181-184	cytochrome b-245 beta chain	Homo sapiens	270-278
11169207-5	2001	However, the incubation of cells expressing human or rabbit pIgR with pIgA induces a comparable IP3 production, and pIgR-transcytosis of either species is accelerated by the protein kinase C (PKC)-activator phorbol myristate acetate.	Tetradecanoylphorbol Acetate	207-232	phosphatidylinositol N-acetylglucosaminyltransferase subunit A	Oryctolagus cuniculus	70-74
11120787-3	2000	In this report, it is demonstrated that PMA-induced CD30 cleavage from Karpas 299 cells was mediated by a membrane-anchored metalloproteinase which was active on intact cells following 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate extraction of membrane preparations.	Tetradecanoylphorbol Acetate	40-43	TNF receptor superfamily member 8	Homo sapiens	52-56
11113454-5	2000	Activation of PKC by both TeTx and TPA results in a loss of transport capacity and serotonin transporter (SERT) phosphorylation, which are abolished by coapplication of the specific PKC inhibitor bisindolylmaleimide-1.	Tetradecanoylphorbol Acetate	35-38	protein kinase C, alpha	Rattus norvegicus	14-17
11078714-4	2000	Depletion of cellular PKC by overnight treatment with phorbol 12-myristate 13-acetate (PMA) similarly augmented ANG II-induced IP production.	Tetradecanoylphorbol Acetate	54-85	protein kinase C, gamma	Rattus norvegicus	22-25
11078714-5	2000	Acute activation of PKC by PMA halved IP formation, with an EC(50) approximately 1 nM; 4alpha-PMA was inactive.	Tetradecanoylphorbol Acetate	27-30	protein kinase C, gamma	Rattus norvegicus	20-23
11096038-7	2000	Regarding the increased expression on in vitro stimulation with phorbol myristate acetate, blunted upregulation was obtained during dialysis using Excebrane membranes for CD11c and CD45 expression on granulocytes and CD14 expression on monocytes.	Tetradecanoylphorbol Acetate	64-89	protein tyrosine phosphatase receptor type C	Homo sapiens	181-185
11145176-5	2000	In cell-attached patches, bath application of phorbol 12-myristate 13-acetate (PMA, 2 microM), a PKC activator, inhibited the activity of the Kca-channel in the presence of the Ca2+ ionophore, A 23187 (10 microM).	Tetradecanoylphorbol Acetate	46-77	protein kinase C, gamma	Rattus norvegicus	97-100
11145176-5	2000	In cell-attached patches, bath application of phorbol 12-myristate 13-acetate (PMA, 2 microM), a PKC activator, inhibited the activity of the Kca-channel in the presence of the Ca2+ ionophore, A 23187 (10 microM).	Tetradecanoylphorbol Acetate	79-82	protein kinase C, gamma	Rattus norvegicus	97-100
11169414-3	2000	ICOS requires both phorbol 12-myristate 13-acetate and ionomycin for full induction, and is sensitive to Cyclosporin A.	Tetradecanoylphorbol Acetate	19-50	inducible T cell costimulator	Homo sapiens	0-4
11139146-14	2000	Furthermore, TPA exposure of U937 cells is associated with increased levels of the pro-apoptotic proteins Bak and Bcl-xs, whereas simultaneously a decline in the Bcl-2 expression was noticable.	Tetradecanoylphorbol Acetate	13-16	BCL2 antagonist/killer 1	Homo sapiens	106-109
11069028-8	2000	Moreover, the differentiation status of these Raf-responsive cells was more immature upon Raf activation as culture with the differentiation-inducing agent phorbol 12 myristate 13-acetate (PMA) and beta-estradiol resulted in decreased levels of the CD11b and CD18 integrin molecules on the cell surface.	Tetradecanoylphorbol Acetate	156-187	integrin subunit alpha M	Homo sapiens	249-254
11069028-8	2000	Moreover, the differentiation status of these Raf-responsive cells was more immature upon Raf activation as culture with the differentiation-inducing agent phorbol 12 myristate 13-acetate (PMA) and beta-estradiol resulted in decreased levels of the CD11b and CD18 integrin molecules on the cell surface.	Tetradecanoylphorbol Acetate	189-192	integrin subunit alpha M	Homo sapiens	249-254
10918063-13	2000	dn-c-Jun mutants abolished PMA-stimulated expression supporting an important role for AP-1 proteins in SPRR1B expression.	Tetradecanoylphorbol Acetate	27-30	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	3-8
10992479-12	2000	Phorbol myristate acetate (PMA) also activated host PLD, while long-term treatment with PMA resulted in loss of the ability of L. monocytogenes to activate host PLD, suggesting an involvement of protein kinase C (PKC) in the activation of PLD.	Tetradecanoylphorbol Acetate	88-91	protein kinase C, delta	Mus musculus	213-216
11074603-4	2000	HK1.ras/alpha-p53(-/-) mice also exhibited an increased epidermal hyperplasia, and, similar to HK1.ras/alpha mice with p53(+/+) and p53(+/-) genotypes, these mice rapidly developed spontaneous and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced papillomas.	Tetradecanoylphorbol Acetate	197-233	hexokinase 1	Mus musculus	0-3
11074603-4	2000	HK1.ras/alpha-p53(-/-) mice also exhibited an increased epidermal hyperplasia, and, similar to HK1.ras/alpha mice with p53(+/+) and p53(+/-) genotypes, these mice rapidly developed spontaneous and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced papillomas.	Tetradecanoylphorbol Acetate	235-238	hexokinase 1	Mus musculus	0-3
11074603-5	2000	These results are in contrast to our previous observation that, HK1.ras, HK1.fos, and HK1.TGFalpha transgenic mice with the p53(-/-) genotype display an unexpected delay in both spontaneous and TPA-promoted papilloma formation compared with mice with p53(+/+) and p53(+/-) genotypes.	Tetradecanoylphorbol Acetate	194-197	hexokinase 1	Mus musculus	64-67
11074603-5	2000	These results are in contrast to our previous observation that, HK1.ras, HK1.fos, and HK1.TGFalpha transgenic mice with the p53(-/-) genotype display an unexpected delay in both spontaneous and TPA-promoted papilloma formation compared with mice with p53(+/+) and p53(+/-) genotypes.	Tetradecanoylphorbol Acetate	194-197	hexokinase 1	Mus musculus	73-76
11074603-5	2000	These results are in contrast to our previous observation that, HK1.ras, HK1.fos, and HK1.TGFalpha transgenic mice with the p53(-/-) genotype display an unexpected delay in both spontaneous and TPA-promoted papilloma formation compared with mice with p53(+/+) and p53(+/-) genotypes.	Tetradecanoylphorbol Acetate	194-197	hexokinase 1	Mus musculus	86-98
11039466-3	2000	Phorbol 12-myristate 13-acetate (TPA) significantly stimulated CCK release.	Tetradecanoylphorbol Acetate	0-31	cholecystokinin	Mus musculus	63-66
11018469-2	2000	Phorbol myristoyl acetate (PMA) strongly stimulated phosphatidylcholine (PtdCho)-specific phospholipase D (PLD) activity in the C3H/10T1/2 Cl8 parental cell line, but not in Cl8 HAbetaC2-1 cells, indicating that full PLD activity in PMA-treated Cl8 cells is dependent on a functional interaction of alpha/betaPKC with RACK1.	Tetradecanoylphorbol Acetate	27-30	Phospholipase D	Drosophila melanogaster	107-110
11018469-2	2000	Phorbol myristoyl acetate (PMA) strongly stimulated phosphatidylcholine (PtdCho)-specific phospholipase D (PLD) activity in the C3H/10T1/2 Cl8 parental cell line, but not in Cl8 HAbetaC2-1 cells, indicating that full PLD activity in PMA-treated Cl8 cells is dependent on a functional interaction of alpha/betaPKC with RACK1.	Tetradecanoylphorbol Acetate	27-30	Phospholipase D	Drosophila melanogaster	217-220
11018469-6	2000	As a supporting experiment, we inhibited PMA-stimulated PtdH formation by PLD, and also putatively PtdH-derived DAG, in Cl8 cells with 1-butanol.	Tetradecanoylphorbol Acetate	41-44	Phospholipase D	Drosophila melanogaster	74-77
11018469-8	2000	The present study shows: (1) PMA-stimulated PLD activity is dependent on a functional interaction between alpha/betaPKC and RACK1 in C3H/10T1/2 Cl8 fibroblasts; and (2) inhibition of PLD activity and PtdH formation did not reduce the cellular uptake and incorporation of labelled choline into PtdCho, indicating that these processes are not directly regulated by PtdCho-PLD activity in PMA-treated C3H/10T1/2 Cl8 fibroblasts.	Tetradecanoylphorbol Acetate	29-32	Phospholipase D	Drosophila melanogaster	44-47
11018469-8	2000	The present study shows: (1) PMA-stimulated PLD activity is dependent on a functional interaction between alpha/betaPKC and RACK1 in C3H/10T1/2 Cl8 fibroblasts; and (2) inhibition of PLD activity and PtdH formation did not reduce the cellular uptake and incorporation of labelled choline into PtdCho, indicating that these processes are not directly regulated by PtdCho-PLD activity in PMA-treated C3H/10T1/2 Cl8 fibroblasts.	Tetradecanoylphorbol Acetate	29-32	Phospholipase D	Drosophila melanogaster	183-186
11018469-8	2000	The present study shows: (1) PMA-stimulated PLD activity is dependent on a functional interaction between alpha/betaPKC and RACK1 in C3H/10T1/2 Cl8 fibroblasts; and (2) inhibition of PLD activity and PtdH formation did not reduce the cellular uptake and incorporation of labelled choline into PtdCho, indicating that these processes are not directly regulated by PtdCho-PLD activity in PMA-treated C3H/10T1/2 Cl8 fibroblasts.	Tetradecanoylphorbol Acetate	29-32	Phospholipase D	Drosophila melanogaster	183-186
10996653-4	2000	Upon prolonged TPA treatment all PKC isoenzymes became downregulated, albeit at different rates (PKCdelta&gt;alpha&gt;mu&gt;beta,theta&gt;&gt;eta,zeta).	Tetradecanoylphorbol Acetate	15-18	protein kinase C, delta	Mus musculus	97-105
10980241-3	2000	This effect was mimicked by co-treatment with a growth factor (aFGF, bFGF or BDNF; but not GDNF, IGF-1, EGF or TGF) and the neurotransmitter 5-HT (but not GABA, dopamine, glutamate) and/or a protein kinase activator (IBMX, forskolin, TPA).	Tetradecanoylphorbol Acetate	234-237	brain derived neurotrophic factor	Homo sapiens	77-81
10978519-0	2000	Similar effects of electroporational stress and treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate on vimentin expression in mouse plasmacytoma cells.	Tetradecanoylphorbol Acetate	81-117	vimentin	Mus musculus	121-129
10978519-4	2000	Additionally, a region located 700 bp upstream of the transcriptional start became hypersensitive to DNase I digestion upon electroporation and TPA treatment.	Tetradecanoylphorbol Acetate	144-147	deoxyribonuclease I	Mus musculus	101-108
10926838-1	2000	Perfusion of rat jejunum in vitro with PMA increased fructose transport by 70% compared with control values and was blocked by the protein kinase C (PKC) inhibitor chelerythrine.	Tetradecanoylphorbol Acetate	39-42	protein kinase C, gamma	Rattus norvegicus	131-147
10926838-1	2000	Perfusion of rat jejunum in vitro with PMA increased fructose transport by 70% compared with control values and was blocked by the protein kinase C (PKC) inhibitor chelerythrine.	Tetradecanoylphorbol Acetate	39-42	protein kinase C, gamma	Rattus norvegicus	149-152
10936484-6	2000	Troglitazone, rosiglitazone, or AGN 4204 inhibited phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 expression.	Tetradecanoylphorbol Acetate	51-82	matrix metallopeptidase 9	Homo sapiens	97-123
10936484-6	2000	Troglitazone, rosiglitazone, or AGN 4204 inhibited phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 expression.	Tetradecanoylphorbol Acetate	84-87	matrix metallopeptidase 9	Homo sapiens	97-123
10930293-9	2000	These observations demonstrate that, C/EBPbeta and c-Jun contribute to the regulation of the TNF-alpha gene in normal macrophages following treatment with PMA.	Tetradecanoylphorbol Acetate	155-158	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	51-56
10856708-4	2000	We also examined the effects of the PLA(2) inhibitors on macrophages stimulated by phorbol 12-myristate 13-acetate (PMA) which directly activates PKC.	Tetradecanoylphorbol Acetate	83-114	phospholipase A2, group IB, pancreas	Mus musculus	36-42
10856708-5	2000	The two structurally different PLA(2) inhibitors showed differential effects on the PMA-induced superoxide generation: pBPB inhibited it but mepacrine did not.	Tetradecanoylphorbol Acetate	84-87	phospholipase A2, group IB, pancreas	Mus musculus	31-37
10914491-3	2000	Rat leukocytes of various sources shed surface L-selectin after phorbol myristate acetate (PMA) treatment, however, these cells retained the ability to bind sulfatide.	Tetradecanoylphorbol Acetate	64-89	selectin L	Rattus norvegicus	47-57
10914491-3	2000	Rat leukocytes of various sources shed surface L-selectin after phorbol myristate acetate (PMA) treatment, however, these cells retained the ability to bind sulfatide.	Tetradecanoylphorbol Acetate	91-94	selectin L	Rattus norvegicus	47-57
10903418-16	2000	The decrease in TPA-induced ODC activity due to GPF treatment is preceded by an inhibition of TPA-induced PKC activity.	Tetradecanoylphorbol Acetate	16-19	ornithine decarboxylase, structural 1	Mus musculus	28-31
10871841-0	2000	Annexin V inhibits the 12-O-tetradecanoylphorbol-13-acetate-induced activation of Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of Shc in MCF-7 cells.	Tetradecanoylphorbol Acetate	23-59	SHC adaptor protein 1	Homo sapiens	160-163
10871841-8	2000	TPA treatment of MCF-7 cells caused an increased association of Shc with Grb2.	Tetradecanoylphorbol Acetate	0-3	SHC adaptor protein 1	Homo sapiens	64-67
10819756-6	2000	Treatment of GV oocytes with the biologically active phorbol ester, 12-o-tetradecanoyl phorbol-13-acetate (TPA), resulted in a rapid translocation of the cytosolic PKC-alpha, but not PKC-betaI, PKC-betaII, or RACK1, to the plasma membrane.	Tetradecanoylphorbol Acetate	68-105	receptor for activated C kinase 1	Mus musculus	209-214
10819756-6	2000	Treatment of GV oocytes with the biologically active phorbol ester, 12-o-tetradecanoyl phorbol-13-acetate (TPA), resulted in a rapid translocation of the cytosolic PKC-alpha, but not PKC-betaI, PKC-betaII, or RACK1, to the plasma membrane.	Tetradecanoylphorbol Acetate	107-110	receptor for activated C kinase 1	Mus musculus	209-214
10889466-8	2000	TPA-induced VEGF secretion was suppressed by SB203580.	Tetradecanoylphorbol Acetate	0-3	vascular endothelial growth factor A	Mus musculus	12-16
10848972-2	2000	In this study, we investigated the induction of adrenomedullin gene expression in THP-1 acute monocytic leukemia cells during differentiation into macrophage-like cells by 12-O-tetradecanoylphorbol-13-acetate (TPA), and identified a cis-regulatory region of the human adrenomedullin gene responsible for TPA-induced adrenomedullin expression.	Tetradecanoylphorbol Acetate	172-208	adrenomedullin	Homo sapiens	48-62
10848972-2	2000	In this study, we investigated the induction of adrenomedullin gene expression in THP-1 acute monocytic leukemia cells during differentiation into macrophage-like cells by 12-O-tetradecanoylphorbol-13-acetate (TPA), and identified a cis-regulatory region of the human adrenomedullin gene responsible for TPA-induced adrenomedullin expression.	Tetradecanoylphorbol Acetate	210-213	adrenomedullin	Homo sapiens	48-62
10848972-2	2000	In this study, we investigated the induction of adrenomedullin gene expression in THP-1 acute monocytic leukemia cells during differentiation into macrophage-like cells by 12-O-tetradecanoylphorbol-13-acetate (TPA), and identified a cis-regulatory region of the human adrenomedullin gene responsible for TPA-induced adrenomedullin expression.	Tetradecanoylphorbol Acetate	304-307	adrenomedullin	Homo sapiens	48-62
10848972-3	2000	Upon treatment with TPA (100 ng x mL(-1)) for 24 h, immunoreactive adrenomedullin concentrations in the culture medium and adrenomedullin mRNA levels were increased more than 10-fold, concomitant with the differentiation of THP-1 cells into macrophage-like cells.	Tetradecanoylphorbol Acetate	20-23	adrenomedullin	Homo sapiens	67-81
10848972-3	2000	Upon treatment with TPA (100 ng x mL(-1)) for 24 h, immunoreactive adrenomedullin concentrations in the culture medium and adrenomedullin mRNA levels were increased more than 10-fold, concomitant with the differentiation of THP-1 cells into macrophage-like cells.	Tetradecanoylphorbol Acetate	20-23	adrenomedullin	Homo sapiens	123-137
10820198-10	2000	We found that CHP100 cells constitutively express both CXCR4 and CCR5 receptors and that stimulation with phorbol 12-myristate 13-acetate down-regulates their expression, thus preventing gp120-induced cell death.	Tetradecanoylphorbol Acetate	106-137	C-X-C motif chemokine receptor 4	Homo sapiens	55-60
10820198-10	2000	We found that CHP100 cells constitutively express both CXCR4 and CCR5 receptors and that stimulation with phorbol 12-myristate 13-acetate down-regulates their expression, thus preventing gp120-induced cell death.	Tetradecanoylphorbol Acetate	106-137	C-C motif chemokine receptor 5	Homo sapiens	65-69
10818238-3	2000	Differentiation of U937 and HPM cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced the H1 receptor expression and rather suppressed the H2 receptor, resulting in up-regulation of the histamine-induced expression and secretion of TNF-alpha, modulated via TACE.	Tetradecanoylphorbol Acetate	43-79	ADAM metallopeptidase domain 17	Homo sapiens	266-270
10818238-3	2000	Differentiation of U937 and HPM cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced the H1 receptor expression and rather suppressed the H2 receptor, resulting in up-regulation of the histamine-induced expression and secretion of TNF-alpha, modulated via TACE.	Tetradecanoylphorbol Acetate	81-84	ADAM metallopeptidase domain 17	Homo sapiens	266-270
10799546-5	2000	Phorbol 12-myristate 13-acetate (PMA), a potent inducer of shedding, decreased cell-surface staining for TACE.	Tetradecanoylphorbol Acetate	0-31	ADAM metallopeptidase domain 17	Homo sapiens	105-109
10799546-5	2000	Phorbol 12-myristate 13-acetate (PMA), a potent inducer of shedding, decreased cell-surface staining for TACE.	Tetradecanoylphorbol Acetate	33-36	ADAM metallopeptidase domain 17	Homo sapiens	105-109
10799546-6	2000	Surface biotinylation experiments confirmed and extended this observation; PMA decreased the half-life of surface-biotinylated TACE without increasing the turnover of total cell-surface proteins.	Tetradecanoylphorbol Acetate	75-78	ADAM metallopeptidase domain 17	Homo sapiens	127-131
10799546-9	2000	Surprisingly, a metalloprotease inhibitor prevented the PMA-induced turnover of TACE.	Tetradecanoylphorbol Acetate	56-59	ADAM metallopeptidase domain 17	Homo sapiens	80-84
10807873-8	2000	Phorbol 12-myristate 13-acetate (PMA) and insulin, 2 known activators of AP-1, increased the binding of AP-1 to the MMP-12 promoter, with higher affinity for the A allele.	Tetradecanoylphorbol Acetate	0-31	matrix metallopeptidase 12	Homo sapiens	116-122
10807873-8	2000	Phorbol 12-myristate 13-acetate (PMA) and insulin, 2 known activators of AP-1, increased the binding of AP-1 to the MMP-12 promoter, with higher affinity for the A allele.	Tetradecanoylphorbol Acetate	33-36	matrix metallopeptidase 12	Homo sapiens	116-122
10790161-6	2000	The protein kinase C (PKC) activator 4beta-phorbol 12-myristate 13-acetate (PMA, 100 pM to 200 nM), also stimulated Ca2+ spiking and this effect was additive with a submaximal concentration of AVP (50 pM).	Tetradecanoylphorbol Acetate	37-74	protein kinase C, alpha	Rattus norvegicus	22-25
10790161-6	2000	The protein kinase C (PKC) activator 4beta-phorbol 12-myristate 13-acetate (PMA, 100 pM to 200 nM), also stimulated Ca2+ spiking and this effect was additive with a submaximal concentration of AVP (50 pM).	Tetradecanoylphorbol Acetate	76-79	protein kinase C, alpha	Rattus norvegicus	22-25
10790161-10	2000	Pretreatment for 24 h with 1 microM PMA downregulated expression of PKC-alpha and -delta, but not PKC-epsilon, and prevented the Ca2+-spiking responses to either 1 nM PMA or 100 pM AVP.	Tetradecanoylphorbol Acetate	36-39	protein kinase C, alpha	Rattus norvegicus	68-88
10821340-8	2000	We also noted that 10(-6) mol/L calphostin C, another PKC inhibitor, or 16-h preincubation with PMA completely blocked this effect of insulin.	Tetradecanoylphorbol Acetate	96-99	insulin	Canis lupus familiaris	134-141
10857476-6	2000	Upon stimulation with phorbol myristate acetate, no fluorescence was seen in intracellular compartments of neutrophils isolated from patients with X-linked chronic granulomatous disease lacking gp91-phox, a membrane component of NADPH oxidase.	Tetradecanoylphorbol Acetate	22-47	cytochrome b-245 beta chain	Homo sapiens	194-203
10792504-8	2000	These results suggest that PMA induces the transcriptional activation of the MCP-3 gene through de novo protein synthesis and the rapid decay of PMA-induced MCP-3 mRNA through de novo synthesis of adenosine/uridine (AU)-rich element binding proteins and cAMP signalling inhibits the PMA-induced transcriptional activation of the MCP-3 gene expression.	Tetradecanoylphorbol Acetate	27-30	C-C motif chemokine ligand 7	Homo sapiens	77-82
10792503-5	2000	PMA also increased the expression of X-chromosome-linked inhibitor of apoptosis protein (XIAP) in U937, suggesting an inhibitory action for XIAP on the caspase cascade in PMA-stimulated U937.	Tetradecanoylphorbol Acetate	0-3	X-linked inhibitor of apoptosis	Homo sapiens	37-87
10792503-5	2000	PMA also increased the expression of X-chromosome-linked inhibitor of apoptosis protein (XIAP) in U937, suggesting an inhibitory action for XIAP on the caspase cascade in PMA-stimulated U937.	Tetradecanoylphorbol Acetate	0-3	X-linked inhibitor of apoptosis	Homo sapiens	89-93
10792503-5	2000	PMA also increased the expression of X-chromosome-linked inhibitor of apoptosis protein (XIAP) in U937, suggesting an inhibitory action for XIAP on the caspase cascade in PMA-stimulated U937.	Tetradecanoylphorbol Acetate	0-3	X-linked inhibitor of apoptosis	Homo sapiens	140-144
10792504-2	2000	In the present study, we examined the regulation of MCP-3 mRNA and protein production in endothelial cells by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA) and cAMP signalling.	Tetradecanoylphorbol Acetate	144-175	C-C motif chemokine ligand 7	Homo sapiens	52-57
10792504-2	2000	In the present study, we examined the regulation of MCP-3 mRNA and protein production in endothelial cells by protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA) and cAMP signalling.	Tetradecanoylphorbol Acetate	177-180	C-C motif chemokine ligand 7	Homo sapiens	52-57
10708546-3	2000	Cystathionine ketimine and NAc-OCPC also enhanced superoxide generation induced by opsonized zymosan (OZ) but not that induced by arachidonic acid (AA) and phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	189-192	X-linked Kx blood group	Homo sapiens	27-30
10723565-7	2000	Exposure of cells to 4 beta-phorbol 12-myristate 13-acetate led to the induction of the immediate early gene c-fos and resulted in an enhanced c-Fos signal, detected by Western blot analysis.	Tetradecanoylphorbol Acetate	23-59	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	109-114
10723565-7	2000	Exposure of cells to 4 beta-phorbol 12-myristate 13-acetate led to the induction of the immediate early gene c-fos and resulted in an enhanced c-Fos signal, detected by Western blot analysis.	Tetradecanoylphorbol Acetate	23-59	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	143-148
10692108-6	2000	Interferon-gamma and the phorbolester 12-O-tetradecanoyl phorbol 13-acetate, two well-known inducers of keratinocyte differentiation, both inhibited vitamin D receptor expression but only interferon-gamma induced retinoid X receptor alpha.	Tetradecanoylphorbol Acetate	38-75	vitamin D receptor	Homo sapiens	149-167
10692108-6	2000	Interferon-gamma and the phorbolester 12-O-tetradecanoyl phorbol 13-acetate, two well-known inducers of keratinocyte differentiation, both inhibited vitamin D receptor expression but only interferon-gamma induced retinoid X receptor alpha.	Tetradecanoylphorbol Acetate	38-75	retinoid X receptor alpha	Homo sapiens	213-238
10692108-7	2000	The decreased vitamin D receptor expression was accompanied by reduced vitamin D responsiveness (as assessed by 24-hydroxylase mRNA induction) in postconfluent, high calcium, and 12-O-tetradecanoyl phorbol 13-acetate treated keratinocytes but not with interferon-gamma treatment.	Tetradecanoylphorbol Acetate	179-216	vitamin D receptor	Homo sapiens	14-32
10775801-8	2000	The high AP1 activities observed during proliferative state or induced in TPA-treated polarized cells, exert a repressive effect on androgen action.	Tetradecanoylphorbol Acetate	74-77	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	9-12
10739005-8	2000	In the case of the monocytic maturation of HL-60 cells treated with phorbol esters (PMA), the abl and bcr homologous genes were repositioned closer to each other and closer to the nuclear centre.	Tetradecanoylphorbol Acetate	84-87	BCR activator of RhoGEF and GTPase	Homo sapiens	102-105
10708482-6	2000	Unlika in parental or single-genotype siblings, in which TPA promotion-elicited papillomas remained benign, TPA promotion elicited autonomous papillomas in HK1 less than, with dotras/alpha mice and exhibited a novel susceptibility to malignant conversion.	Tetradecanoylphorbol Acetate	108-111	hexokinase 1	Mus musculus	156-159
10708482-7	2000	Sequence analysis of the endogenous c-Ha-ras from spontaneous and TPA-induced HK1 less than, with dotras/alpha papillomas revealed wild-type sequence.	Tetradecanoylphorbol Acetate	66-69	Harvey rat sarcoma virus oncogene	Mus musculus	36-44
10708482-7	2000	Sequence analysis of the endogenous c-Ha-ras from spontaneous and TPA-induced HK1 less than, with dotras/alpha papillomas revealed wild-type sequence.	Tetradecanoylphorbol Acetate	66-69	hexokinase 1	Mus musculus	78-81
10651808-6	2000	This potentiation was observed even at high doses of PMA (200 nM) which alone had stimulated the O-2 response maximally.	Tetradecanoylphorbol Acetate	53-56	immunoglobulin kappa variable 1D-39	Homo sapiens	97-100
10651808-11	2000	These results suggest that ethanol potentiates PMA-induced O-2 production through increasing PKC translocation and activity in PMNs.	Tetradecanoylphorbol Acetate	47-50	immunoglobulin kappa variable 1D-39	Homo sapiens	59-62
10670466-3	2000	RESULTS: Preactivation of PKC by phorbol 12-myristate 13-acetate (PMA), or inhibition of protein phosphatase type 1/2A (PP1/2A) by calyculin A, decreased both the [Ca2+]i transient and the plateau of [Ca2+]i induced by increasing concentrations of carbachol, a cholinergic agonist.	Tetradecanoylphorbol Acetate	33-64	protein kinase C, gamma	Rattus norvegicus	26-29
10670466-3	2000	RESULTS: Preactivation of PKC by phorbol 12-myristate 13-acetate (PMA), or inhibition of protein phosphatase type 1/2A (PP1/2A) by calyculin A, decreased both the [Ca2+]i transient and the plateau of [Ca2+]i induced by increasing concentrations of carbachol, a cholinergic agonist.	Tetradecanoylphorbol Acetate	66-69	protein kinase C, gamma	Rattus norvegicus	26-29
10674396-14	2000	The potential role of PKC was suggested by the observation that the well known PKC activator phorbol-12-myristate-13-acetate (PMA) potentiated the IL-4-induced 3beta-HSD activity.	Tetradecanoylphorbol Acetate	93-124	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	160-169
10674396-14	2000	The potential role of PKC was suggested by the observation that the well known PKC activator phorbol-12-myristate-13-acetate (PMA) potentiated the IL-4-induced 3beta-HSD activity.	Tetradecanoylphorbol Acetate	126-129	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	160-169
11281287-8	2000	The downregulation of alpha-tocopherol on the TPA-mediated GPIIb promoter activity may result in a reduction of GPIIb protein expression and thus contribute to antiplatelet aggregation.	Tetradecanoylphorbol Acetate	46-49	integrin subunit alpha 2b	Homo sapiens	59-64
11281287-8	2000	The downregulation of alpha-tocopherol on the TPA-mediated GPIIb promoter activity may result in a reduction of GPIIb protein expression and thus contribute to antiplatelet aggregation.	Tetradecanoylphorbol Acetate	46-49	integrin subunit alpha 2b	Homo sapiens	112-117
10617662-3	2000	Using normal human keratinocytes in conventional cultures and skin grafted onto nude mice in vivo, we show that retinoids can inhibit TPA-mediated VEGF gene induction at the transcriptional level.	Tetradecanoylphorbol Acetate	134-137	vascular endothelial growth factor A	Mus musculus	147-151
11268405-5	2000	Moreover, PMA + ionomycin, which mimic the proliferative signal of anti-CD3, inhibited the expression of DOR mRNA.	Tetradecanoylphorbol Acetate	10-13	opioid receptor, delta 1	Mus musculus	105-108
10630309-4	2000	Phorbol 12-myristate 13-acetate and all-trans-retinoic acid, which induce differentiation in U-937 cells, up-regulated CD11b (MAC1 alpha-integrin) and CD82 and down-regulated CD71 (transferrin receptor) in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	0-31	integrin subunit alpha M	Homo sapiens	119-124
10630309-4	2000	Phorbol 12-myristate 13-acetate and all-trans-retinoic acid, which induce differentiation in U-937 cells, up-regulated CD11b (MAC1 alpha-integrin) and CD82 and down-regulated CD71 (transferrin receptor) in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	0-31	integrin subunit alpha M	Homo sapiens	126-136
10630309-4	2000	Phorbol 12-myristate 13-acetate and all-trans-retinoic acid, which induce differentiation in U-937 cells, up-regulated CD11b (MAC1 alpha-integrin) and CD82 and down-regulated CD71 (transferrin receptor) in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	0-31	CD82 molecule	Homo sapiens	151-155
11448065-2	2000	Unstimulated cocultures did not form capillaries and produce MMP-9 but stimulation with the protein kinase C (PKC) activator 4-phorbol-12-myristate 13-acetate (PMA) produced MMP-9 and capillary networks.	Tetradecanoylphorbol Acetate	160-163	matrix metallopeptidase 9	Homo sapiens	174-179
11448065-6	2000	Finally, PMA-induced MMP-9 expression and capillary formation were inhibited by the MEKK-specific inhibitor PD98059.	Tetradecanoylphorbol Acetate	9-12	matrix metallopeptidase 9	Homo sapiens	21-26
10662890-7	2000	Application of 12-O-tetradecanoylphorbol 13-acetate (TPA), an activator of PKC, mimicked the effect of NA.	Tetradecanoylphorbol Acetate	15-51	Prkca	Cavia porcellus	75-78
10662890-7	2000	Application of 12-O-tetradecanoylphorbol 13-acetate (TPA), an activator of PKC, mimicked the effect of NA.	Tetradecanoylphorbol Acetate	53-56	Prkca	Cavia porcellus	75-78
10612690-6	2000	In the absence of inactivation, the macroscopic conductance decreased and inactivation became visible at voltages positive of +50 mV when the rCx46-expressing oocytes were treated with the protein-kinase-C-activators OAG or TPA, high external concentrations of Ca(2+) or H(+).	Tetradecanoylphorbol Acetate	224-227	gap junction protein, alpha 3	Rattus norvegicus	142-147
10600794-6	1999	12-O-tetradecanoylphorbol 13-acetate (TPA), a PKC activator, induced the HSP 27 accumulation and the expression of mRNA for HSP 27.	Tetradecanoylphorbol Acetate	0-36	heat shock protein 1	Mus musculus	73-79
10600794-6	1999	12-O-tetradecanoylphorbol 13-acetate (TPA), a PKC activator, induced the HSP 27 accumulation and the expression of mRNA for HSP 27.	Tetradecanoylphorbol Acetate	0-36	heat shock protein 1	Mus musculus	124-130
10600794-6	1999	12-O-tetradecanoylphorbol 13-acetate (TPA), a PKC activator, induced the HSP 27 accumulation and the expression of mRNA for HSP 27.	Tetradecanoylphorbol Acetate	38-41	heat shock protein 1	Mus musculus	73-79
10600794-6	1999	12-O-tetradecanoylphorbol 13-acetate (TPA), a PKC activator, induced the HSP 27 accumulation and the expression of mRNA for HSP 27.	Tetradecanoylphorbol Acetate	38-41	heat shock protein 1	Mus musculus	124-130
10571249-4	1999	An 8-hr pretreatment with PMA, which led to down-regulation of PKC-alpha and -delta isoenzymes, still inhibited sPLA2-IIA induction.	Tetradecanoylphorbol Acetate	26-29	protein kinase C, alpha	Rattus norvegicus	63-83
10602019-8	1999	These results suggest that the T cell stimulation via anti-CD3 cross-linking or phorbol myristate acetate treatment up-regulates CD82 expression, leading to the colocalization of CD82 and LFA-1, and results in enhanced interaction between LFA-1 and ICAM-1.	Tetradecanoylphorbol Acetate	80-105	CD82 molecule	Homo sapiens	129-133
10602019-8	1999	These results suggest that the T cell stimulation via anti-CD3 cross-linking or phorbol myristate acetate treatment up-regulates CD82 expression, leading to the colocalization of CD82 and LFA-1, and results in enhanced interaction between LFA-1 and ICAM-1.	Tetradecanoylphorbol Acetate	80-105	CD82 molecule	Homo sapiens	179-183
10602019-8	1999	These results suggest that the T cell stimulation via anti-CD3 cross-linking or phorbol myristate acetate treatment up-regulates CD82 expression, leading to the colocalization of CD82 and LFA-1, and results in enhanced interaction between LFA-1 and ICAM-1.	Tetradecanoylphorbol Acetate	80-105	intercellular adhesion molecule 1	Homo sapiens	249-255
10528234-9	1999	Both the cyclic adenosine monophosphate (cAMP) analogue, 8-bromo-cAMP (8-Br-cAMP), and the protein kinase C (PKC) activator, phorbol myristate acetate, increased collagenase-3 expression, while the calcium ionophore, ionomycin, did not, suggesting that PTH was acting through the protein kinase A (PKA) and PKC pathways.	Tetradecanoylphorbol Acetate	125-150	matrix metallopeptidase 13	Rattus norvegicus	162-175
10558913-6	1999	Interestingly, okadaic acid-induced upregulation of VEGF mRNA was not suppressed by protein kinase C (PKC) inhibitor or by tumor necrosis factor alpha blocking antibody, although TPA-induced VEGF upregulation was strongly suppressed by PKC inhibitor.	Tetradecanoylphorbol Acetate	179-182	vascular endothelial growth factor A	Mus musculus	191-195
10597271-6	1999	The transient arrest of HC11 cells following treatment with TPA was associated with marked induction of both p21cip1 mRNA and protein.	Tetradecanoylphorbol Acetate	60-63	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	109-116
10523861-1	1999	Activator protein 1 (AP-1) transactivation and ornithine decarboxylase (ODC) activity have been established as essential downstream effectors of mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	175-211	ornithine decarboxylase, structural 1	Mus musculus	47-70
10523861-1	1999	Activator protein 1 (AP-1) transactivation and ornithine decarboxylase (ODC) activity have been established as essential downstream effectors of mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	175-211	ornithine decarboxylase, structural 1	Mus musculus	72-75
10526255-7	1999	Somatostatin and lanreotide treatment inhibited phorbol myristate acetate (PMA)-induced cell proliferation.	Tetradecanoylphorbol Acetate	48-73	somatostatin	Homo sapiens	0-12
10526255-7	1999	Somatostatin and lanreotide treatment inhibited phorbol myristate acetate (PMA)-induced cell proliferation.	Tetradecanoylphorbol Acetate	75-78	somatostatin	Homo sapiens	0-12
10564368-10	1999	Furthermore, pretreatment of the neurons with the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), attenuated the N/OFQ inhibition of the calcium channel current whereas the cAMP-dependent kinase A activator, forskolin, showed no effect, suggesting the probable involvement of PKC in the N/OFQ-induced desensitization.	Tetradecanoylphorbol Acetate	84-115	protein kinase C, gamma	Rattus norvegicus	301-304
10564368-10	1999	Furthermore, pretreatment of the neurons with the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), attenuated the N/OFQ inhibition of the calcium channel current whereas the cAMP-dependent kinase A activator, forskolin, showed no effect, suggesting the probable involvement of PKC in the N/OFQ-induced desensitization.	Tetradecanoylphorbol Acetate	117-120	protein kinase C, gamma	Rattus norvegicus	50-66
10564368-10	1999	Furthermore, pretreatment of the neurons with the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), attenuated the N/OFQ inhibition of the calcium channel current whereas the cAMP-dependent kinase A activator, forskolin, showed no effect, suggesting the probable involvement of PKC in the N/OFQ-induced desensitization.	Tetradecanoylphorbol Acetate	117-120	protein kinase C, gamma	Rattus norvegicus	68-71
10564368-10	1999	Furthermore, pretreatment of the neurons with the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), attenuated the N/OFQ inhibition of the calcium channel current whereas the cAMP-dependent kinase A activator, forskolin, showed no effect, suggesting the probable involvement of PKC in the N/OFQ-induced desensitization.	Tetradecanoylphorbol Acetate	117-120	protein kinase C, gamma	Rattus norvegicus	301-304
10540223-10	1999	In subcellular fractions, Rac2 was found to translocate, along with p47phox and p67phox, from cytosol to plasma membrane-associated fractions following phorbol myristate acetate stimulation, while RhoGDI remained within cytosolic fractions.	Tetradecanoylphorbol Acetate	152-177	neutrophil cytosolic factor 1	Homo sapiens	68-75
10464284-5	1999	Concomitant with TPA-induced CD44 cleavage, TPA treatment induces redistribution of CD44 and ERM proteins (ezrin, radixin, and moesin) to newly generated membrane ruffling areas.	Tetradecanoylphorbol Acetate	17-20	CD44 molecule (Indian blood group)	Homo sapiens	29-33
10464284-5	1999	Concomitant with TPA-induced CD44 cleavage, TPA treatment induces redistribution of CD44 and ERM proteins (ezrin, radixin, and moesin) to newly generated membrane ruffling areas.	Tetradecanoylphorbol Acetate	17-20	CD44 molecule (Indian blood group)	Homo sapiens	84-88
10464284-5	1999	Concomitant with TPA-induced CD44 cleavage, TPA treatment induces redistribution of CD44 and ERM proteins (ezrin, radixin, and moesin) to newly generated membrane ruffling areas.	Tetradecanoylphorbol Acetate	44-47	CD44 molecule (Indian blood group)	Homo sapiens	29-33
10464284-5	1999	Concomitant with TPA-induced CD44 cleavage, TPA treatment induces redistribution of CD44 and ERM proteins (ezrin, radixin, and moesin) to newly generated membrane ruffling areas.	Tetradecanoylphorbol Acetate	44-47	CD44 molecule (Indian blood group)	Homo sapiens	84-88
10464284-6	1999	Treatment with lysophosphatidic acid, which is known to activate the Rho-dependent pathway, inhibits TPA-induced CD44 redistribution and CD44 cleavage.	Tetradecanoylphorbol Acetate	101-104	CD44 molecule (Indian blood group)	Homo sapiens	113-117
10464284-6	1999	Treatment with lysophosphatidic acid, which is known to activate the Rho-dependent pathway, inhibits TPA-induced CD44 redistribution and CD44 cleavage.	Tetradecanoylphorbol Acetate	101-104	CD44 molecule (Indian blood group)	Homo sapiens	137-141
10674181-4	1999	NA reduced tumor growth, inhibited the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase activity, but induced the transglutaminase activity which was inhibited by TPA under different experimental conditions.	Tetradecanoylphorbol Acetate	39-75	ornithine decarboxylase, structural 1	Mus musculus	90-113
10674181-4	1999	NA reduced tumor growth, inhibited the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase activity, but induced the transglutaminase activity which was inhibited by TPA under different experimental conditions.	Tetradecanoylphorbol Acetate	77-80	ornithine decarboxylase, structural 1	Mus musculus	90-113
10469612-6	1999	The data indicate that c-Ha-ras mutations can be detected in normal-looking and hyperplastic epidermal cells as well as in tumor cells obtained from mice initiated with BP and promoted with TPA.	Tetradecanoylphorbol Acetate	190-193	Harvey rat sarcoma virus oncogene	Mus musculus	23-31
10547870-4	1999	These cell lines were used to determine how expression of the hIR influences the capacity of g33 to respond to insulin and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	123-148	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	62-65
10547870-4	1999	These cell lines were used to determine how expression of the hIR influences the capacity of g33 to respond to insulin and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	150-153	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	62-65
10468528-6	1999	Apoptosis was the predominant form of cell death when PKC had been activated by H(2)O(2) alone or by H(2)O(2) in the presence of 50 nmol/L phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	139-170	protein kinase C, gamma	Rattus norvegicus	54-57
10467416-6	1999	TPA treatment reduced p27 expression in keratinocytes also supporting a role for p27 during promotion.	Tetradecanoylphorbol Acetate	0-3	cyclin-dependent kinase inhibitor 1B	Mus musculus	22-25
10467416-6	1999	TPA treatment reduced p27 expression in keratinocytes also supporting a role for p27 during promotion.	Tetradecanoylphorbol Acetate	0-3	cyclin-dependent kinase inhibitor 1B	Mus musculus	81-84
10444518-5	1999	We examined the PKC isomers that are translocated by ATP, UTP, TPA, and dioctanoylglycerol in cultured type II cells isolated from adult rats.	Tetradecanoylphorbol Acetate	63-66	protein kinase C, alpha	Rattus norvegicus	16-19
10444518-8	1999	TPA and dioctanoylglycerol also activated PKC-alpha, -betaI, -betaII, -delta, and -eta, but those isoforms were not activated by ATP or UTP.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	42-86
10426820-6	1999	In screening anti-tumor promoting effects, APS (180 micrograms/ml) significantly inhibited phorbol myristic acetate (PMA)-induced ornithine decarboxylase activity in Balb/3T3 cells.	Tetradecanoylphorbol Acetate	117-120	ornithine decarboxylase, structural 1	Mus musculus	130-153
10446961-8	1999	Costimulation of normal phorbol 12-myristate 13-acetate-treated B cells with the CCR5 ligand RANTES induced a proliferative response, indicating that RANTES is a mitogen for B cells.	Tetradecanoylphorbol Acetate	24-55	C-C motif chemokine receptor 5	Homo sapiens	81-85
10446961-8	1999	Costimulation of normal phorbol 12-myristate 13-acetate-treated B cells with the CCR5 ligand RANTES induced a proliferative response, indicating that RANTES is a mitogen for B cells.	Tetradecanoylphorbol Acetate	24-55	C-C motif chemokine ligand 5	Homo sapiens	93-99
10446961-8	1999	Costimulation of normal phorbol 12-myristate 13-acetate-treated B cells with the CCR5 ligand RANTES induced a proliferative response, indicating that RANTES is a mitogen for B cells.	Tetradecanoylphorbol Acetate	24-55	C-C motif chemokine ligand 5	Homo sapiens	150-156
10458779-5	1999	Cultured mast cells and HMC-1 cells treated with phorbol 12-myristate 13-acetate were shown to express MMP9 mRNA, and the cultured conditioned media from these cells showed gelatinolytic activity, identical with MMP9.	Tetradecanoylphorbol Acetate	49-80	matrix metallopeptidase 9	Homo sapiens	103-107
10458779-5	1999	Cultured mast cells and HMC-1 cells treated with phorbol 12-myristate 13-acetate were shown to express MMP9 mRNA, and the cultured conditioned media from these cells showed gelatinolytic activity, identical with MMP9.	Tetradecanoylphorbol Acetate	49-80	matrix metallopeptidase 9	Homo sapiens	212-216
10399964-3	1999	We have previously presented an in vitro two-dimensional cohort migration model, in which highly metastatic variant L-10 cells of human rectal adenocarcinoma cell line RCM-1 moved as coherent cell sheets when stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) or hepatocyte growth factor/scatter factor (HGF/SF).	Tetradecanoylphorbol Acetate	225-261	troponin I3, cardiac type	Homo sapiens	168-173
10399964-3	1999	We have previously presented an in vitro two-dimensional cohort migration model, in which highly metastatic variant L-10 cells of human rectal adenocarcinoma cell line RCM-1 moved as coherent cell sheets when stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) or hepatocyte growth factor/scatter factor (HGF/SF).	Tetradecanoylphorbol Acetate	263-266	troponin I3, cardiac type	Homo sapiens	168-173
10489901-2	1999	MATERIALS AND METHODS: The induction of c-jun transcripts by IR, by phorbol 12-myristate 13-acetate (PMA), interleukin 1 (IL-1) and epidermal growth factor (EGF) in normal and A-T lymphoblasts was measured.	Tetradecanoylphorbol Acetate	68-99	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	40-45
10352425-5	1999	Incubation of rat proximal tubules with phorbol 12-myristate 13-acetate resulted in a 50% reduction in membrane-associated NEP activity.	Tetradecanoylphorbol Acetate	40-71	membrane metallo-endopeptidase	Rattus norvegicus	123-126
10410976-7	1999	Polyclonal activation of lung T cells from OA/OA mice with 12-myristate 13-acetate (PMA), ionomycin, anti-CD3 mAb, and anti-CD28 mAb resulted in higher percentages of IL-2+ (43%) and IL-5+ (7%) CD4 cells when compared to CD4+ T cells from non-OA sensitized, challenged mice.	Tetradecanoylphorbol Acetate	84-87	CD4 antigen	Mus musculus	194-197
10410976-7	1999	Polyclonal activation of lung T cells from OA/OA mice with 12-myristate 13-acetate (PMA), ionomycin, anti-CD3 mAb, and anti-CD28 mAb resulted in higher percentages of IL-2+ (43%) and IL-5+ (7%) CD4 cells when compared to CD4+ T cells from non-OA sensitized, challenged mice.	Tetradecanoylphorbol Acetate	84-87	CD4 antigen	Mus musculus	221-224
10374822-10	1999	Treatment of the cells with TPA significantly activated translocation of conventional PKC-gamma from the cytosol to the membrane and nuclear fractions and other PKC isozymes (-alpha, -delta, and -epsilon) from the cytosol to the membrane, but not atypical PKC-zeta and -lambda.	Tetradecanoylphorbol Acetate	28-31	protein kinase C, gamma	Rattus norvegicus	86-95
10374822-10	1999	Treatment of the cells with TPA significantly activated translocation of conventional PKC-gamma from the cytosol to the membrane and nuclear fractions and other PKC isozymes (-alpha, -delta, and -epsilon) from the cytosol to the membrane, but not atypical PKC-zeta and -lambda.	Tetradecanoylphorbol Acetate	28-31	protein kinase C, gamma	Rattus norvegicus	86-89
10374822-13	1999	Taking the results together, differential activation/translocation of PKC isozymes by KCN and TPA is important in the regulation of chemical hypoxia-induced cell injury in PC12 cells.	Tetradecanoylphorbol Acetate	94-97	protein kinase C, gamma	Rattus norvegicus	70-73
10382590-6	1999	In addition, hydrogen peroxide, lysophosphatidylcholine or phorbol 12-myristate 13-acetate also decreased the expression of PPARgamma.	Tetradecanoylphorbol Acetate	59-90	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	124-133
10380902-2	1999	Because many SNARE proteins appear to be common mediators of exocytosis, we examined phorbol myristate acetate-stimulated expression of CD11b and CD69 on polymorphonuclear leukocytes (PMN) from Type 2 diabetic subjects with hypertension and microalbuminuria (D-htma), hypertension only (D-ht) or uncomplicated (D-uc), and normal controls (NC) by flow cytometry.	Tetradecanoylphorbol Acetate	85-110	integrin subunit alpha M	Homo sapiens	136-141
10365914-3	1999	HK1.IGF1 transgenic mice, which overexpress IGF-1 in epidermis via the human keratin 1 promoter, were previously shown to be hypersensitive to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	167-203	hexokinase 1	Mus musculus	0-3
10365914-3	1999	HK1.IGF1 transgenic mice, which overexpress IGF-1 in epidermis via the human keratin 1 promoter, were previously shown to be hypersensitive to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	205-208	hexokinase 1	Mus musculus	0-3
10336422-7	1999	Our data showed that LE135 and LE540 strongly repressed 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity in the presence of RARbeta and RXRalpha.	Tetradecanoylphorbol Acetate	56-92	retinoid X receptor alpha	Homo sapiens	146-154
10336429-3	1999	Here we report that when protein kinase C (PKC) pathways were activated in human glioblastoma U373 cells by phorbol 12-myristate 13-acetate (PMA), VEGF mRNA expression was up-regulated via a post-transcriptional mRNA stabilization mechanism.	Tetradecanoylphorbol Acetate	108-139	protein kinase C zeta	Homo sapiens	43-46
10329970-2	1999	We examined the role of NHE3 phosphorylation in regulating its activity in response to PKC activation by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	105-136	solute carrier family 9 member A3	Homo sapiens	24-28
10329970-2	1999	We examined the role of NHE3 phosphorylation in regulating its activity in response to PKC activation by phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	138-141	solute carrier family 9 member A3	Homo sapiens	24-28
10208993-3	1999	Incubation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA; 10(-7) M) was associated with a transient induction in both cell fractions of calcium/phosphatidylserine-dependent PKC activity, which was elevated from 15 min to 1 h. Consistent with this, mRNAs for the calcium/phospholipid-dependent isomeric forms of PKC (alpha, beta, and gamma) were detected.	Tetradecanoylphorbol Acetate	34-70	protein kinase C, alpha	Rattus norvegicus	192-195
10208993-3	1999	Incubation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA; 10(-7) M) was associated with a transient induction in both cell fractions of calcium/phosphatidylserine-dependent PKC activity, which was elevated from 15 min to 1 h. Consistent with this, mRNAs for the calcium/phospholipid-dependent isomeric forms of PKC (alpha, beta, and gamma) were detected.	Tetradecanoylphorbol Acetate	34-70	protein kinase C, alpha	Rattus norvegicus	330-357
10208993-3	1999	Incubation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA; 10(-7) M) was associated with a transient induction in both cell fractions of calcium/phosphatidylserine-dependent PKC activity, which was elevated from 15 min to 1 h. Consistent with this, mRNAs for the calcium/phospholipid-dependent isomeric forms of PKC (alpha, beta, and gamma) were detected.	Tetradecanoylphorbol Acetate	72-75	protein kinase C, alpha	Rattus norvegicus	192-195
10208993-3	1999	Incubation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA; 10(-7) M) was associated with a transient induction in both cell fractions of calcium/phosphatidylserine-dependent PKC activity, which was elevated from 15 min to 1 h. Consistent with this, mRNAs for the calcium/phospholipid-dependent isomeric forms of PKC (alpha, beta, and gamma) were detected.	Tetradecanoylphorbol Acetate	72-75	protein kinase C, alpha	Rattus norvegicus	330-357
10208993-4	1999	The expression levels of mRNAs for PKCalpha and PKCbeta were also up-regulated (2.5- to 3-fold) by TPA (10(-7) M), but these effects were much slower (peaking after 12 h) than those on phosphotransferase activity.	Tetradecanoylphorbol Acetate	99-102	protein kinase C, alpha	Rattus norvegicus	35-43
10208993-4	1999	The expression levels of mRNAs for PKCalpha and PKCbeta were also up-regulated (2.5- to 3-fold) by TPA (10(-7) M), but these effects were much slower (peaking after 12 h) than those on phosphotransferase activity.	Tetradecanoylphorbol Acetate	99-102	protein kinase C, beta	Rattus norvegicus	48-55
10208993-5	1999	In the presence of TPA (10(-7) M), expression of androgen receptor (AR) mRNA showed a transient time-dependent down-regulation ( approximately 70%), in which the nadir was reached after 6 h and baseline expression was again obtained after 12 h. The regulatory effect of PKC activation on AR mRNA was confirmed by the absence of response to a biologically inactive phorbol ester.	Tetradecanoylphorbol Acetate	19-22	androgen receptor	Rattus norvegicus	49-66
10208993-5	1999	In the presence of TPA (10(-7) M), expression of androgen receptor (AR) mRNA showed a transient time-dependent down-regulation ( approximately 70%), in which the nadir was reached after 6 h and baseline expression was again obtained after 12 h. The regulatory effect of PKC activation on AR mRNA was confirmed by the absence of response to a biologically inactive phorbol ester.	Tetradecanoylphorbol Acetate	19-22	androgen receptor	Rattus norvegicus	68-70
10208993-5	1999	In the presence of TPA (10(-7) M), expression of androgen receptor (AR) mRNA showed a transient time-dependent down-regulation ( approximately 70%), in which the nadir was reached after 6 h and baseline expression was again obtained after 12 h. The regulatory effect of PKC activation on AR mRNA was confirmed by the absence of response to a biologically inactive phorbol ester.	Tetradecanoylphorbol Acetate	19-22	protein kinase C, alpha	Rattus norvegicus	270-273
10208993-5	1999	In the presence of TPA (10(-7) M), expression of androgen receptor (AR) mRNA showed a transient time-dependent down-regulation ( approximately 70%), in which the nadir was reached after 6 h and baseline expression was again obtained after 12 h. The regulatory effect of PKC activation on AR mRNA was confirmed by the absence of response to a biologically inactive phorbol ester.	Tetradecanoylphorbol Acetate	19-22	androgen receptor	Rattus norvegicus	288-290
10208993-6	1999	A concentration-dependent decrease (half-maximal effect at approximately 10(-8) M TPA) of AR mRNA was also observed.	Tetradecanoylphorbol Acetate	82-85	androgen receptor	Rattus norvegicus	90-92
10359012-5	1999	Furthermore, PD98059 completely blocked the TPA-induced differentiation of ML-1 cells, as assessed by a number of features associated with mononuclear differentiation including changes in morphology, nonspecific esterase activity, phagocytic ability, NADPH oxidase activity, mitochondrial respiration, and c-jun mRNA inducibility.	Tetradecanoylphorbol Acetate	44-47	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	306-311
10199555-10	1999	PMA-induced cell rounding can be reversed by the PKC-specific inhibitor GF109203X.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, delta	Mus musculus	49-52
10199818-1	1999	The cloned epithelial cell-specific Na+/H+ exchanger (NHE) isoform NHE2 is stimulated by fibroblast growth factor (FGF), phorbol 12-myristate 13-acetate (PMA), okadaic acid (OA), and fetal bovine serum (FBS) through a change in maximal velocity of the transporter.	Tetradecanoylphorbol Acetate	121-152	solute carrier family 9 member A2	Homo sapiens	67-71
10199818-1	1999	The cloned epithelial cell-specific Na+/H+ exchanger (NHE) isoform NHE2 is stimulated by fibroblast growth factor (FGF), phorbol 12-myristate 13-acetate (PMA), okadaic acid (OA), and fetal bovine serum (FBS) through a change in maximal velocity of the transporter.	Tetradecanoylphorbol Acetate	154-157	solute carrier family 9 member A2	Homo sapiens	67-71
11225735-5	1999	NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells, and both VCAM-1 and ICAM-1 were significantly induced in these cells in response to tumor necrosis factor-alpha (TNF-alpha) and phorbol 12-myristate 13-acetate (PMA) stimulation, as studied by flow cytometry.	Tetradecanoylphorbol Acetate	233-264	intercellular adhesion molecule 1	Homo sapiens	125-131
11225735-5	1999	NF-kappaB activation was greatly potentiated by increased 15-LO activity in the stably transduced cells, and both VCAM-1 and ICAM-1 were significantly induced in these cells in response to tumor necrosis factor-alpha (TNF-alpha) and phorbol 12-myristate 13-acetate (PMA) stimulation, as studied by flow cytometry.	Tetradecanoylphorbol Acetate	266-269	intercellular adhesion molecule 1	Homo sapiens	125-131
10328864-2	1999	Our data showed that IL-17 mRNA was highly expressed in memory human peripheral CD8(+)45RO+T cells and CD4(+)45RO+T cells when peripheral blood mononuclear cells were first stimulated with ionomycin/PMA.	Tetradecanoylphorbol Acetate	199-202	interleukin 17A	Homo sapiens	21-26
10098510-9	1999	Elevation of c-Jun expression by other means, e.g. 12-O tetradecanoyl-phorbol-13-acetate or transfecting with a c-Jun expression vector, abolished the transcriptional activity of the GR.	Tetradecanoylphorbol Acetate	51-88	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	183-185
10342421-3	1999	In our experiments, we have used local microdialysis administration of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to activate PKC in the spinal cord dorsal horn in awake rats.	Tetradecanoylphorbol Acetate	127-130	protein kinase C, gamma	Rattus norvegicus	144-147
10090765-2	1999	Previously we have demonstrated that protein kinase Calpha (PKCalpha) directly interacts with phospholipase D1 (PLD1), activating the enzymatic activity of PLD1 in the presence of phorbol 12-myristate 13-acetate (PMA) [Lee, T. G., et al.	Tetradecanoylphorbol Acetate	180-211	protein kinase C, alpha	Rattus norvegicus	37-58
10090765-2	1999	Previously we have demonstrated that protein kinase Calpha (PKCalpha) directly interacts with phospholipase D1 (PLD1), activating the enzymatic activity of PLD1 in the presence of phorbol 12-myristate 13-acetate (PMA) [Lee, T. G., et al.	Tetradecanoylphorbol Acetate	180-211	protein kinase C, alpha	Rattus norvegicus	60-68
10090765-2	1999	Previously we have demonstrated that protein kinase Calpha (PKCalpha) directly interacts with phospholipase D1 (PLD1), activating the enzymatic activity of PLD1 in the presence of phorbol 12-myristate 13-acetate (PMA) [Lee, T. G., et al.	Tetradecanoylphorbol Acetate	213-216	protein kinase C, alpha	Rattus norvegicus	37-58
10090765-2	1999	Previously we have demonstrated that protein kinase Calpha (PKCalpha) directly interacts with phospholipase D1 (PLD1), activating the enzymatic activity of PLD1 in the presence of phorbol 12-myristate 13-acetate (PMA) [Lee, T. G., et al.	Tetradecanoylphorbol Acetate	213-216	protein kinase C, alpha	Rattus norvegicus	60-68
10090765-10	1999	PMA elicits translocation of PKCalpha to the CEMs, inducing PLD activation through the interaction of PKCalpha with PLD1 in the CEMs.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	29-37
10090765-10	1999	PMA elicits translocation of PKCalpha to the CEMs, inducing PLD activation through the interaction of PKCalpha with PLD1 in the CEMs.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	102-110
10068670-3	1999	Previously, we demonstrated that release of soluble tie-1 receptor from endothelial cells by phorbol myristate acetate (PMA) is mediated through protein kinase C and a Ca2+-dependent protease.	Tetradecanoylphorbol Acetate	93-118	tyrosine kinase with immunoglobulin like and EGF like domains 1	Homo sapiens	52-57
10068670-3	1999	Previously, we demonstrated that release of soluble tie-1 receptor from endothelial cells by phorbol myristate acetate (PMA) is mediated through protein kinase C and a Ca2+-dependent protease.	Tetradecanoylphorbol Acetate	120-123	tyrosine kinase with immunoglobulin like and EGF like domains 1	Homo sapiens	52-57
10037491-3	1999	Treatment of microglia with A beta (25-35) at 10 nM or 12-O-tetradecanoylphorbol 13-acetate (1.6 nM) led to phosphorylation of MARCKS, an event inhibited by PKC inhibitors, staurosporine, calphostin C, and chelerythrine.	Tetradecanoylphorbol Acetate	55-91	amyloid beta precursor protein	Rattus norvegicus	28-34
10037491-3	1999	Treatment of microglia with A beta (25-35) at 10 nM or 12-O-tetradecanoylphorbol 13-acetate (1.6 nM) led to phosphorylation of MARCKS, an event inhibited by PKC inhibitors, staurosporine, calphostin C, and chelerythrine.	Tetradecanoylphorbol Acetate	55-91	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	127-133
10096423-3	1999	Pretreatment of mouse skin with 5, 10, 20 and 30 mg of GSP resulted in a dose-dependent reduction in TPA-induced epidermal ODC activity of 27, 37, 48 and 70%, respectively, compared to controls.	Tetradecanoylphorbol Acetate	101-104	ornithine decarboxylase, structural 1	Mus musculus	123-126
10096423-8	1999	The mechanism of this tumor inhibition is due, in part, to a GSP-associated inhibition of TPA-induced epidermal ODC and MPO activities.	Tetradecanoylphorbol Acetate	90-93	ornithine decarboxylase, structural 1	Mus musculus	112-115
10096423-8	1999	The mechanism of this tumor inhibition is due, in part, to a GSP-associated inhibition of TPA-induced epidermal ODC and MPO activities.	Tetradecanoylphorbol Acetate	90-93	myeloperoxidase	Mus musculus	120-123
9880563-6	1999	Serum response factor (SRF), Elk-1, and Sp1 bound to cognate sites within this segment, SRF and Elk-1 acting coordinately to affect both basal activity and TPA inducibility, whereas Sp1 affected basal activity only.	Tetradecanoylphorbol Acetate	156-159	serum response factor	Homo sapiens	0-21
9880563-6	1999	Serum response factor (SRF), Elk-1, and Sp1 bound to cognate sites within this segment, SRF and Elk-1 acting coordinately to affect both basal activity and TPA inducibility, whereas Sp1 affected basal activity only.	Tetradecanoylphorbol Acetate	156-159	serum response factor	Homo sapiens	23-26
9880563-6	1999	Serum response factor (SRF), Elk-1, and Sp1 bound to cognate sites within this segment, SRF and Elk-1 acting coordinately to affect both basal activity and TPA inducibility, whereas Sp1 affected basal activity only.	Tetradecanoylphorbol Acetate	156-159	ETS transcription factor ELK1	Homo sapiens	29-34
9880563-6	1999	Serum response factor (SRF), Elk-1, and Sp1 bound to cognate sites within this segment, SRF and Elk-1 acting coordinately to affect both basal activity and TPA inducibility, whereas Sp1 affected basal activity only.	Tetradecanoylphorbol Acetate	156-159	serum response factor	Homo sapiens	88-91
9880563-6	1999	Serum response factor (SRF), Elk-1, and Sp1 bound to cognate sites within this segment, SRF and Elk-1 acting coordinately to affect both basal activity and TPA inducibility, whereas Sp1 affected basal activity only.	Tetradecanoylphorbol Acetate	156-159	ETS transcription factor ELK1	Homo sapiens	96-101
9880563-7	1999	Thus, the mechanism of the TPA-induced increase in MCL1 expression seen in myelomonocytic cells at early stages of differentiation involves signal transduction through ERKs and transcriptional activation through SRF/Elk-1.	Tetradecanoylphorbol Acetate	27-30	serum response factor	Homo sapiens	212-215
9880563-7	1999	Thus, the mechanism of the TPA-induced increase in MCL1 expression seen in myelomonocytic cells at early stages of differentiation involves signal transduction through ERKs and transcriptional activation through SRF/Elk-1.	Tetradecanoylphorbol Acetate	27-30	ETS transcription factor ELK1	Homo sapiens	216-221
9935238-6	1999	Treatment of PMK-R1 keratinocytes with 100 nM of the mitogen 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in activation of PKCmu, reflected by translocation from the cytosolic to the particulate fraction and by shifts in electrophoretic mobility.	Tetradecanoylphorbol Acetate	61-97	protein kinase D1	Homo sapiens	130-135
9935238-6	1999	Treatment of PMK-R1 keratinocytes with 100 nM of the mitogen 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in activation of PKCmu, reflected by translocation from the cytosolic to the particulate fraction and by shifts in electrophoretic mobility.	Tetradecanoylphorbol Acetate	99-102	protein kinase D1	Homo sapiens	130-135
10529599-3	1999	We measured here beta1 and beta2 integrin on eosinophils stimulated by phorbol-12-myristate-13-acetate (PMA)/ionomycin to evaluate eosinophil activation in vitro using whole blood.	Tetradecanoylphorbol Acetate	71-102	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	17-22
10529599-3	1999	We measured here beta1 and beta2 integrin on eosinophils stimulated by phorbol-12-myristate-13-acetate (PMA)/ionomycin to evaluate eosinophil activation in vitro using whole blood.	Tetradecanoylphorbol Acetate	104-107	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	17-22
9886240-5	1999	MIC-1 is not expressed in resting macrophages but is induced by a number of different activation agents, including phorbol myristate acetate, interleukin 1, tumor necrosis factor alpha, and macrophage colony-stimulating factor but not by lipopolysaccharide or interferon-gamma.	Tetradecanoylphorbol Acetate	115-140	growth differentiation factor 15	Homo sapiens	0-5
9862721-5	1998	Moreover, PMA was able to induce a normal phosphorylation of the cytosolic factor p47phox and to fully activate extracellular signal-regulated kinases (Erk1/2).	Tetradecanoylphorbol Acetate	10-13	neutrophil cytosolic factor 1	Homo sapiens	82-89
9874176-6	1998	Phorbol myristate acetate was also able to increase c-fos mRNA expression.	Tetradecanoylphorbol Acetate	0-25	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-57
9876227-2	1998	CD45RA or CD45RO CD4 T cells were cultured for 4 days with phorbol myristate acetate (PMA) and ionomycin and either IL-4, IFN-gamma or IL-12 and their ability to proliferate and secrete IFN-gamma and IL-4 determined.	Tetradecanoylphorbol Acetate	59-84	protein tyrosine phosphatase receptor type C	Homo sapiens	0-4
9876227-2	1998	CD45RA or CD45RO CD4 T cells were cultured for 4 days with phorbol myristate acetate (PMA) and ionomycin and either IL-4, IFN-gamma or IL-12 and their ability to proliferate and secrete IFN-gamma and IL-4 determined.	Tetradecanoylphorbol Acetate	86-89	protein tyrosine phosphatase receptor type C	Homo sapiens	0-4
10052620-12	1998	Thus, in our non-palindromic oligonucleotide the water molecules bind differently to A11 and A15 although both adenines are part of a TpA step.	Tetradecanoylphorbol Acetate	134-137	immunoglobulin kappa variable 1-32 (pseudogene)	Homo sapiens	93-96
9856820-6	1998	CD4+ T cells and CD8 + T cells from AD-H patients, cultured for 48 h with phorbol 12-myristate 13-acetate and ionomycin, released larger amounts of IL-4 and IL-13 but smaller amounts of IFN-gamma than both types of cells from AD-L patients or healthy controls.	Tetradecanoylphorbol Acetate	74-105	CD8a molecule	Homo sapiens	17-20
9879660-4	1998	Treatment of PC12 cells with a combination of agents (NGF, forskolin, and tetradecanoylphorbol acetate [TPA]) increased c-fos expression over that detected with NGF alone.	Tetradecanoylphorbol Acetate	74-102	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	120-125
9879660-4	1998	Treatment of PC12 cells with a combination of agents (NGF, forskolin, and tetradecanoylphorbol acetate [TPA]) increased c-fos expression over that detected with NGF alone.	Tetradecanoylphorbol Acetate	104-107	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	120-125
9831704-8	1998	Treatment of VSMCs with the PPARgamma ligands troglitazone and the naturally occurring 15-deoxy-Delta12, 14-prostaglandin J2 (15d-PGJ2) decreased phorbol 12-myristate 13-acetate-induced MMP-9 mRNA and protein levels, as well as MMP-9 gelatinolytic activity in the supernatants in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	146-177	matrix metallopeptidase 9	Homo sapiens	186-191
9831704-8	1998	Treatment of VSMCs with the PPARgamma ligands troglitazone and the naturally occurring 15-deoxy-Delta12, 14-prostaglandin J2 (15d-PGJ2) decreased phorbol 12-myristate 13-acetate-induced MMP-9 mRNA and protein levels, as well as MMP-9 gelatinolytic activity in the supernatants in a concentration-dependent manner.	Tetradecanoylphorbol Acetate	146-177	matrix metallopeptidase 9	Homo sapiens	228-233
9972133-4	1998	Doxycycline (50 microM) completely inhibited the phorbol-12-myristate-13-acetate (PMA)-mediated induction of MMP-8 and MMP-9, as measured by Western blotting and gelatin zymography, respectively.	Tetradecanoylphorbol Acetate	49-80	matrix metallopeptidase 9	Homo sapiens	119-124
9972133-4	1998	Doxycycline (50 microM) completely inhibited the phorbol-12-myristate-13-acetate (PMA)-mediated induction of MMP-8 and MMP-9, as measured by Western blotting and gelatin zymography, respectively.	Tetradecanoylphorbol Acetate	82-85	matrix metallopeptidase 9	Homo sapiens	119-124
9878122-3	1998	Expression of IL-17 mRNA in CD8(+) T cell was induced by prior activation of PBMC for 18 h with Ca2+ ionophore and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	115-140	interleukin 17A	Homo sapiens	14-19
9878122-3	1998	Expression of IL-17 mRNA in CD8(+) T cell was induced by prior activation of PBMC for 18 h with Ca2+ ionophore and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	115-140	CD8a molecule	Homo sapiens	28-31
9878122-3	1998	Expression of IL-17 mRNA in CD8(+) T cell was induced by prior activation of PBMC for 18 h with Ca2+ ionophore and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	142-145	interleukin 17A	Homo sapiens	14-19
9878122-3	1998	Expression of IL-17 mRNA in CD8(+) T cell was induced by prior activation of PBMC for 18 h with Ca2+ ionophore and phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	142-145	CD8a molecule	Homo sapiens	28-31
9765254-3	1998	Depletion of beta-PKC in dHL60 cells elicited selective inhibition of O-2 generation triggered by fMet-Leu-Phe, immune complexes, or phorbol myristate acetate, an activator of PKC.	Tetradecanoylphorbol Acetate	133-158	immunoglobulin kappa variable 1D-39	Homo sapiens	70-73
9760255-3	1998	Through deletion analysis of the PARS regulatory gene, we found that the sequence within the first intron region was responsible for the TPA-dependent repression.	Tetradecanoylphorbol Acetate	137-140	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	33-37
9760255-9	1998	These results suggest that abolishment of the binding of a special nuclear protein to the first intron of the PARS gene is related to the TPA-responsive downregulation of PARS in U937 cells.	Tetradecanoylphorbol Acetate	138-141	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	110-114
9760255-9	1998	These results suggest that abolishment of the binding of a special nuclear protein to the first intron of the PARS gene is related to the TPA-responsive downregulation of PARS in U937 cells.	Tetradecanoylphorbol Acetate	138-141	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	171-175
9808188-6	1998	A decrease in surface expression of CXCR4 was found when lymphocytes cultured overnight for maximal receptor expression were stimulated with phytohemagglutinin, anti-CD3 antibodies, phorbol 12-myristate 13-acetate and stromal cell-derived factor-1.	Tetradecanoylphorbol Acetate	182-213	C-X-C motif chemokine receptor 4	Homo sapiens	36-41
9755245-5	1998	In HTC cells, the volume-dependent Cl- current response (-46 +/- 5 pA/pF) was inhibited by down-regulation of PKC (100 nmol/L phorbol 12-myristate 13-acetate for 18 hours [PMA]; -1.97 +/- 1.5 pA/pF), chelation of cytosolic Ca2+ (2 mmol/L EGTA; -5.3 +/- 4.0 pA/pF), depletion of cytosolic adenosine triphosphate (ATP) (3 U/mL apyrase; -12.58 +/- 1.	Tetradecanoylphorbol Acetate	126-157	protein kinase C, gamma	Rattus norvegicus	110-113
9758735-15	1998	In comparison, phorbol myristate acetate, a protein kinase C (PKC) activator, restored TNF and PCA production despite the presence of IL-10.	Tetradecanoylphorbol Acetate	15-40	interleukin 10	Homo sapiens	134-139
9743532-3	1998	Mouse mast cells release VPF/VEGF upon stimulation through Fcepsilon receptor I (FcepsilonRI) or c-kit, or after challenge with the protein kinase C activator, phorbol myristate acetate, or the calcium ionophore, A23187; such mast cells can rapidly release VPF/VEGF, apparently from a preformed pool, and can then sustain release by secreting newly synthesized protein.	Tetradecanoylphorbol Acetate	160-185	vascular endothelial growth factor A	Mus musculus	257-260
9743532-3	1998	Mouse mast cells release VPF/VEGF upon stimulation through Fcepsilon receptor I (FcepsilonRI) or c-kit, or after challenge with the protein kinase C activator, phorbol myristate acetate, or the calcium ionophore, A23187; such mast cells can rapidly release VPF/VEGF, apparently from a preformed pool, and can then sustain release by secreting newly synthesized protein.	Tetradecanoylphorbol Acetate	160-185	vascular endothelial growth factor A	Mus musculus	261-265
9733728-8	1998	Co-transfection of the hINV promoter with dominant negative forms of Ras, MEKK1, MEK1, MEK7, MEK3, p38/RK, and c-Jun inhibit the TPA-dependent increase.	Tetradecanoylphorbol Acetate	129-132	mitogen-activated protein kinase kinase 3	Homo sapiens	93-97
9733728-8	1998	Co-transfection of the hINV promoter with dominant negative forms of Ras, MEKK1, MEK1, MEK7, MEK3, p38/RK, and c-Jun inhibit the TPA-dependent increase.	Tetradecanoylphorbol Acetate	129-132	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	111-116
9731508-4	1998	Here, we show that the level of MGMT mRNA in HeLa S3 cells was increased 3-5-fold by phorbol-12-myristate-13-acetate (TPA) and 1,2-diacyl-sn-glycerol (DAG), which are activators of protein kinase C (PKC), as well as by okadaic acid, an inhibitor of protein phosphatases.	Tetradecanoylphorbol Acetate	85-116	O-6-methylguanine-DNA methyltransferase	Homo sapiens	32-36
9731508-4	1998	Here, we show that the level of MGMT mRNA in HeLa S3 cells was increased 3-5-fold by phorbol-12-myristate-13-acetate (TPA) and 1,2-diacyl-sn-glycerol (DAG), which are activators of protein kinase C (PKC), as well as by okadaic acid, an inhibitor of protein phosphatases.	Tetradecanoylphorbol Acetate	118-121	O-6-methylguanine-DNA methyltransferase	Homo sapiens	32-36
9731508-5	1998	The PKC inhibitor 1-(5-isoquinoline sulfonyl)-2-methylpiperazine-HCl eliminated MGMT activation by TPA and DAG but not by OA.	Tetradecanoylphorbol Acetate	99-102	O-6-methylguanine-DNA methyltransferase	Homo sapiens	80-84
9731508-9	1998	That TPA-mediated induction of MGMT caused increased cellular resistance to 2-chloroethyl-N-nitrosourea suggests a therapeutic significance for PKC-mediated MGMT modulation.	Tetradecanoylphorbol Acetate	5-8	O-6-methylguanine-DNA methyltransferase	Homo sapiens	31-35
9731508-9	1998	That TPA-mediated induction of MGMT caused increased cellular resistance to 2-chloroethyl-N-nitrosourea suggests a therapeutic significance for PKC-mediated MGMT modulation.	Tetradecanoylphorbol Acetate	5-8	O-6-methylguanine-DNA methyltransferase	Homo sapiens	157-161
9796620-0	1998	Characterization of a TPA-response element in the 5"-flanking region of the androgen receptor gene.	Tetradecanoylphorbol Acetate	22-25	androgen receptor	Mus musculus	76-93
9796620-7	1998	Thus, these results describe a TRE in the 5"-flanking region of the AR gene and demonstrate that the TRE is responsive to TPA treatment.	Tetradecanoylphorbol Acetate	122-125	androgen receptor	Mus musculus	68-70
9710591-1	1998	The proto-oncogenes jun and fos are members of the AP-1 family of transcription factors, which activate transcription of target genes via the tetradecanoyl phorbol acetate response element (TRE).	Tetradecanoylphorbol Acetate	142-171	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	28-31
9712916-17	1998	Treatment of the NIH 3T3 cells with specific cytokines (i.e. interleukin-6) and other agonists (i.e. lipopolysaccharide) caused a substantially increased level of 125I-UG binding but the same cells, when treated with platelet-derived growth factor, tumor necrosis factor-alpha, interferon-gamma, and phorbol 12-myristate 13-acetate, did not alter the UG binding.	Tetradecanoylphorbol Acetate	300-331	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	168-170
9754929-8	1998	The stimulatory effects of IGF-II were potentiated by UK-14304 (5-bromo-6-[2-imidazolin-2-ylamino]-quinoxaline) (10(-5) M) and inhibited by phenylephrine, PMA, metaproterenol, 8-bromo-cAMP, PD98059, rapamycin, and pertussis toxin.	Tetradecanoylphorbol Acetate	155-158	insulin-like growth factor 2	Rattus norvegicus	27-33
9744516-5	1998	Simultaneous exposure to PMA and sphingosine blocked stimulation of CD11b and PKC expression without affecting growth arrest and VDR down regulation.	Tetradecanoylphorbol Acetate	25-28	integrin subunit alpha M	Homo sapiens	68-73
9726816-8	1998	Although the transcription factors NFkappaB and AP-1 cooperatively decreased their DNA-binding activities to kappaB and 12-O-tetradecanoylphorbol-13-acetate-responsive elements, respectively, and p53 increased DNA-binding activity in the early stage but decreased it in the latter stage after treatment with PTDS, when the human Hep G2 cells were undergoing apoptosis.	Tetradecanoylphorbol Acetate	120-156	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	48-52
9783907-5	1998	GnRH-induced IPs desensitization was potentiated after direct activation of PKC by the phorbol ester TPA, suggesting the involvement of distinct mechanisms in the uncoupling exerted by either GnRH or TPA on GnRH-stimulated PI hydrolysis.	Tetradecanoylphorbol Acetate	101-104	protein kinase C, delta	Mus musculus	76-79
9783907-5	1998	GnRH-induced IPs desensitization was potentiated after direct activation of PKC by the phorbol ester TPA, suggesting the involvement of distinct mechanisms in the uncoupling exerted by either GnRH or TPA on GnRH-stimulated PI hydrolysis.	Tetradecanoylphorbol Acetate	200-203	protein kinase C, delta	Mus musculus	76-79
9783907-9	1998	AlphaT3-1 cells possess several PKC isoforms which, except PKCzeta, were differentially down-regulated by TPA (PKCalpha, betaII, delta, epsilon, eta) or GnRH (PKCbetaII, delta, epsilon, eta).	Tetradecanoylphorbol Acetate	106-109	protein kinase C, delta	Mus musculus	32-35
9670939-9	1998	The intracellular incorporation of Abs specific for c-Fos and c-Jun family members by scrape loading inhibited the production and intracellular accumulation of IL-2 within 6 h of costimulation with PMA/ionomycin, or costimulation by CD28 and CD3 ligation.	Tetradecanoylphorbol Acetate	198-201	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-57
9670939-9	1998	The intracellular incorporation of Abs specific for c-Fos and c-Jun family members by scrape loading inhibited the production and intracellular accumulation of IL-2 within 6 h of costimulation with PMA/ionomycin, or costimulation by CD28 and CD3 ligation.	Tetradecanoylphorbol Acetate	198-201	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	62-67
9681997-4	1998	After treatment with phorbol 12-myristate 13-acetate (PMA), hsp70-overexpressing cells (HL-60/hsp70) underwent rapid growth arrest and plastic adherence and expressed more CD14 than parental HL-60 or empty vector-transformed cells (HL-60/puro).	Tetradecanoylphorbol Acetate	21-52	heat shock protein family A (Hsp70) member 4	Homo sapiens	60-65
9681997-4	1998	After treatment with phorbol 12-myristate 13-acetate (PMA), hsp70-overexpressing cells (HL-60/hsp70) underwent rapid growth arrest and plastic adherence and expressed more CD14 than parental HL-60 or empty vector-transformed cells (HL-60/puro).	Tetradecanoylphorbol Acetate	21-52	heat shock protein family A (Hsp70) member 4	Homo sapiens	94-99
9681997-4	1998	After treatment with phorbol 12-myristate 13-acetate (PMA), hsp70-overexpressing cells (HL-60/hsp70) underwent rapid growth arrest and plastic adherence and expressed more CD14 than parental HL-60 or empty vector-transformed cells (HL-60/puro).	Tetradecanoylphorbol Acetate	54-57	heat shock protein family A (Hsp70) member 4	Homo sapiens	60-65
9688860-14	1998	PMA stimulated 27% more mucin release at 4.7 microM than at 10 nM Ca2+.	Tetradecanoylphorbol Acetate	0-3	solute carrier family 13 member 2	Rattus norvegicus	24-29
9691223-4	1998	Second, the activations of both mitogen-activated protein (MAP) kinase and c-Jun N-terminal kinase (JNK) were attenuated in lpr DN cells upon direct activation by TPA/A23187.	Tetradecanoylphorbol Acetate	163-166	mitogen-activated protein kinase 8	Mus musculus	75-98
9691223-4	1998	Second, the activations of both mitogen-activated protein (MAP) kinase and c-Jun N-terminal kinase (JNK) were attenuated in lpr DN cells upon direct activation by TPA/A23187.	Tetradecanoylphorbol Acetate	163-166	mitogen-activated protein kinase 8	Mus musculus	100-103
9665201-5	1998	Whereas 12-O-tetradecanoylphorbol-13 acetate (TPA) increased both MMP-9 and TIMP-1 mRNA levels, tumor necrosis factor-alpha (TNF-alpha) stimulated only MMP-9 gene expression in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	8-44	matrix metallopeptidase 9	Homo sapiens	66-71
9665201-5	1998	Whereas 12-O-tetradecanoylphorbol-13 acetate (TPA) increased both MMP-9 and TIMP-1 mRNA levels, tumor necrosis factor-alpha (TNF-alpha) stimulated only MMP-9 gene expression in a dose- and time-dependent manner.	Tetradecanoylphorbol Acetate	46-49	matrix metallopeptidase 9	Homo sapiens	66-71
9665201-6	1998	Neutralizing monoclonal antibodies (MoABs) to TNF-alpha (anti-TNF-alpha) decreased the constitutive and TPA-dependent expression of MMP-9 but did not influence TIMP-1 expression, either in unstimulated or in TPA-treated NB4 cells.	Tetradecanoylphorbol Acetate	104-107	matrix metallopeptidase 9	Homo sapiens	132-137
9674743-8	1998	In contrast, TIMP-3 and a hydroxamate-based metalloproteinase inhibitor (BB-94), inhibited both constitutive and PMA-induced release of sIL-6R.	Tetradecanoylphorbol Acetate	113-116	TIMP metallopeptidase inhibitor 3	Homo sapiens	13-19
9711216-5	1998	In vivo, the application of K1115 A decreased phorbol myristate acetate (PMA)-induced mouse ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	46-71	ornithine decarboxylase, structural 1	Mus musculus	92-115
9711216-5	1998	In vivo, the application of K1115 A decreased phorbol myristate acetate (PMA)-induced mouse ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	46-71	ornithine decarboxylase, structural 1	Mus musculus	117-120
9711216-5	1998	In vivo, the application of K1115 A decreased phorbol myristate acetate (PMA)-induced mouse ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	73-76	ornithine decarboxylase, structural 1	Mus musculus	92-115
9711216-5	1998	In vivo, the application of K1115 A decreased phorbol myristate acetate (PMA)-induced mouse ornithine decarboxylase (ODC) activity.	Tetradecanoylphorbol Acetate	73-76	ornithine decarboxylase, structural 1	Mus musculus	117-120
9626657-6	1998	Coexpression of dominant negative and constitutively active forms of CDC42, Rac1, Ras, MEKK1, and MEK1 with JNK indicated that JNK activation by GnRH and TPA is mediated by CDC42 and MEKK1.	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase 8	Mus musculus	108-111
9626657-6	1998	Coexpression of dominant negative and constitutively active forms of CDC42, Rac1, Ras, MEKK1, and MEK1 with JNK indicated that JNK activation by GnRH and TPA is mediated by CDC42 and MEKK1.	Tetradecanoylphorbol Acetate	154-157	mitogen-activated protein kinase 8	Mus musculus	127-130
11324578-2	1998	The results were as follows: (1) PKC agonist phorbol-12-myristate, 13-acetate (PMA) stimulated the glutamate uptake in the rat cerebral cortex synaptosomes and cell line of BT-325, but not in the cell line of SK-N-SH.	Tetradecanoylphorbol Acetate	79-82	protein kinase C, gamma	Rattus norvegicus	33-36
9565574-4	1998	Phorbol 12-myristate 13-acetate (PMA) markedly induced MMP-9 gene expression in HL-60 cells; the induction closely paralleled the timing and extent of PMA-induced cell adhesion and spreading, a hallmark of macrophage differentiation.	Tetradecanoylphorbol Acetate	0-31	matrix metallopeptidase 9	Homo sapiens	55-60
9565574-4	1998	Phorbol 12-myristate 13-acetate (PMA) markedly induced MMP-9 gene expression in HL-60 cells; the induction closely paralleled the timing and extent of PMA-induced cell adhesion and spreading, a hallmark of macrophage differentiation.	Tetradecanoylphorbol Acetate	33-36	matrix metallopeptidase 9	Homo sapiens	55-60
9565575-8	1998	However, anti-TNF-alpha antibodies blocked PMA-induced augmentation of both alpha5 and beta1 integrin gene expression without affecting the expression of the FN gene.	Tetradecanoylphorbol Acetate	43-46	integrin subunit beta 1	Homo sapiens	87-101
9566900-9	1998	U937 cells expressing ectopic wild-type c-Jun or TAM-67 secreted over threefold more TNF alpha than the control line in response to PMA plus lipopolysaccharide.	Tetradecanoylphorbol Acetate	132-135	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	40-45
9555086-11	1998	The PKC inhibitor GF109203X completely abolished TPA-induced PLD activity, however, it only inhibited NMB-induced PLD activity by 20%.	Tetradecanoylphorbol Acetate	49-52	protein kinase C, gamma	Rattus norvegicus	4-7
9535822-10	1998	Concurrent addition of 12-O-tetradecanoylphorbol 13-acetate (TPA) with HGF/SF augmented the apoptosis induced by the growth factor, while TPA alone caused little death.	Tetradecanoylphorbol Acetate	61-64	hepatocyte growth factor	Mus musculus	71-77
9528955-1	1998	This study revealed an important and unexpected finding: namely, that inhibitory melatonin receptors can inhibit a phorbol 12,13 myristate acetate (PMA)-induced, protein kinase C (PKC)-dependent increase in c-fos messenger RNA expression in ovine pars tuberalis (PT) cells.	Tetradecanoylphorbol Acetate	148-151	protein c-Fos	Ovis aries	207-212
9528955-2	1998	PMA induces dose-dependent stimulation of c-fos expression that is attenuated by melatonin in a dose-dependent and pertussis toxin-sensitive manner.	Tetradecanoylphorbol Acetate	0-3	protein c-Fos	Ovis aries	42-47
9528983-6	1998	Nevertheless, the phorbol ester phorbol 12-myristate 13-acetate (50 ng/ml) does activate MAPK in the IM-9 cell, and immunoprecipitation with specific antibodies indicates that this activation occurs through c-Raf-1.	Tetradecanoylphorbol Acetate	32-63	TNF receptor associated factor 3	Homo sapiens	207-214
9571987-2	1998	In this study, we report that cell viability after exposure to NaCN (10 mM, 1 h) is enhanced by the overexpression of HSP-70 resulting from heat shock (45 degrees C, 10 min), treatment with a protein kinase C activator phorbol 12 myristate 13-acetate (PMA; 1 microM, 4 h), or HSP-70 cDNA transfection.	Tetradecanoylphorbol Acetate	252-255	heat shock protein family A (Hsp70) member 4	Homo sapiens	118-124
9600638-2	1998	Treatment with interferon-gamma (100 U/ml) or the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA) (16.2 nM) induced ICAM-1 expression.	Tetradecanoylphorbol Acetate	77-113	intercellular adhesion molecule 1	Homo sapiens	138-144
9600638-2	1998	Treatment with interferon-gamma (100 U/ml) or the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA) (16.2 nM) induced ICAM-1 expression.	Tetradecanoylphorbol Acetate	115-118	intercellular adhesion molecule 1	Homo sapiens	138-144
9600638-4	1998	The TPA-induced ICAM-1 expression was reduced by the protein kinase C inhibitor Ro 31-8425 (1 to 10 microM), but not by the tyrosine kinase inhibitor genistein (185 microM).	Tetradecanoylphorbol Acetate	4-7	intercellular adhesion molecule 1	Homo sapiens	16-22
9600638-9	1998	Combined treatment with interferon-gamma and TPA induced more than additive ICAM-1 expression.	Tetradecanoylphorbol Acetate	45-48	intercellular adhesion molecule 1	Homo sapiens	76-82
9515796-4	1998	We found that inhibition of p38 by SB 203580 resulted in the almost complete reduction of phorbol myristate acetate-induced MMP-9 secretion but not of urokinase-type plasminogen activator secretion.	Tetradecanoylphorbol Acetate	90-115	matrix metallopeptidase 9	Homo sapiens	124-129
9497312-4	1998	We now report that protein kinase C activators, phorbol 12,13-dibutyrate, and phorbol 12-myristate 13-acetate strongly stimulate the phosphorylation of AQP4 and inhibit its activity in a dose-dependent manner.	Tetradecanoylphorbol Acetate	78-109	aquaporin 4	Homo sapiens	152-156
9497312-5	1998	Phorbol 12,13-dibutyrate (10 microM) and phorbol 12-myristate 13-acetate (10 nM) reduced the rate of AQP4-expressing oocyte swelling by 87 and 92%, respectively.	Tetradecanoylphorbol Acetate	41-72	aquaporin 4	Homo sapiens	101-105
9566710-1	1998	We have demonstrated previously that a phosphorothioate antisense oligonucleotide to the p65 subunit of the inducible transcription factor NF-kappaB produced rapid changes in the expression of leukocyte integrin CD11b (Mo 1) and in the adhesion of dimethylsulfoxide (DMSO)-differentiated HL-60 cells stimulated by 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	314-350	integrin subunit alpha M	Homo sapiens	212-217
9537651-3	1998	Of these sites, PEA3 and STAT contributed specifically to induction by v-src, whereas the remaining elements were also involved in induction by the phorbol ester phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	162-187	ETS variant transcription factor 4	Homo sapiens	16-20
9537651-3	1998	Of these sites, PEA3 and STAT contributed specifically to induction by v-src, whereas the remaining elements were also involved in induction by the phorbol ester phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	189-192	ETS variant transcription factor 4	Homo sapiens	16-20
9484987-7	1998	The shear stress inductions of the promoters of monocyte chemotactic protein-1 (MCP-1) and c-fos, driven by TPA-responsive element (TRE) and serum-responsive element (SRE), respectively, were attenuated by v-src(K295R).	Tetradecanoylphorbol Acetate	108-111	C-C motif chemokine 2	Bos taurus	48-78
9484987-7	1998	The shear stress inductions of the promoters of monocyte chemotactic protein-1 (MCP-1) and c-fos, driven by TPA-responsive element (TRE) and serum-responsive element (SRE), respectively, were attenuated by v-src(K295R).	Tetradecanoylphorbol Acetate	108-111	C-C motif chemokine 2	Bos taurus	80-85
9447980-4	1998	Proteasome inhibitors also blocked the tumor-promoting effects of TPA on 3Y1 cells overexpressing c-Src, which results from the depletion of PKC delta.	Tetradecanoylphorbol Acetate	66-69	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	98-103
9447980-5	1998	Consistent with the involvement of the ubiquitin-proteasome pathway in the degradation of PKC isoforms, ubiquitinated PKC alpha, delta, and epsilon were detected within 30 min of TPA treatment.	Tetradecanoylphorbol Acetate	179-182	protein kinase C, alpha	Rattus norvegicus	90-93
9447980-5	1998	Consistent with the involvement of the ubiquitin-proteasome pathway in the degradation of PKC isoforms, ubiquitinated PKC alpha, delta, and epsilon were detected within 30 min of TPA treatment.	Tetradecanoylphorbol Acetate	179-182	protein kinase C, alpha	Rattus norvegicus	118-127
9447980-7	1998	Compounds that inhibit activation of PKC prevented both TPA- and diacylglycerol-induced PKC depletion and ubiquitination.	Tetradecanoylphorbol Acetate	56-59	protein kinase C, alpha	Rattus norvegicus	37-40
9447980-7	1998	Compounds that inhibit activation of PKC prevented both TPA- and diacylglycerol-induced PKC depletion and ubiquitination.	Tetradecanoylphorbol Acetate	56-59	protein kinase C, alpha	Rattus norvegicus	88-91
9447980-8	1998	Moreover, a kinase-dead ATP-binding mutant of PKC alpha could not be depleted by TPA treatment.	Tetradecanoylphorbol Acetate	81-84	protein kinase C, alpha	Rattus norvegicus	46-55
9551905-6	1998	It thus seems that CD4+8+ thymocytes of the two species respond with opposite lineage decisions to strong activating signals such as given by TCR-specific mAb or PMA/ionomycin.	Tetradecanoylphorbol Acetate	162-165	Cd4 molecule	Rattus norvegicus	19-22
9467952-3	1998	Expression of immediate-early genes of the c-fos and c-jun families, whose transcription and activation are regulated by MAP kinases, is differentially induced by insulin and TPA.	Tetradecanoylphorbol Acetate	175-178	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	43-48
9467952-3	1998	Expression of immediate-early genes of the c-fos and c-jun families, whose transcription and activation are regulated by MAP kinases, is differentially induced by insulin and TPA.	Tetradecanoylphorbol Acetate	175-178	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	53-58
9929743-9	1998	The calmodulin antagonists inhibited the PMA-induced increase in CD44 expression on LB cells, but had no influence on the ability of the constitutive HA-binder HA9 cell line to interact with HA, indicating an effect on the PMA induction phase rather than on the binding itself.	Tetradecanoylphorbol Acetate	41-44	calmodulin 2	Mus musculus	4-14
9929743-9	1998	The calmodulin antagonists inhibited the PMA-induced increase in CD44 expression on LB cells, but had no influence on the ability of the constitutive HA-binder HA9 cell line to interact with HA, indicating an effect on the PMA induction phase rather than on the binding itself.	Tetradecanoylphorbol Acetate	41-44	CD44 antigen	Mus musculus	65-69
9929743-10	1998	Verapamil also blocked the PMA-induced increase in CD44 expression on LB cells, but in addition it slightly reduced the ability of the HA9 cells to bind HA without affecting their CD44 expression level.	Tetradecanoylphorbol Acetate	27-30	CD44 antigen	Mus musculus	51-55
9704334-10	1998	Phorbol 12-myristate 13-acetate (PMA, 2 or 5 nM) protected CCE cells against apoptosis induced by the introduction of TGF-beta 1 and withdrawal of aFGF, bFGF or VEGF, while H7 (50 microM), but not HA1004 (50 microM), abrogated the protective effect of PMA on CCE apoptosis.	Tetradecanoylphorbol Acetate	33-36	vascular endothelial growth factor A	Mus musculus	161-165
9407095-6	1997	Significantly, pretreatment of Swiss 3T3 fibroblasts with 1 microM phorbol 12-myristate 13-acetate for 24 h, or with the selective protein kinase C inhibitor Ro-31-8220, reduced LPA-stimulated phosphorylation of Tiam1 by approximately 75%.	Tetradecanoylphorbol Acetate	67-98	TIAM Rac1 associated GEF 1	Homo sapiens	212-217
9407095-7	1997	Moreover, acute stimulation with 100 nM phorbol 12-myristate 13-acetate was sufficient to induce Tiam1 phosphorylation in vivo, and protein kinase C could phosphorylate purified Tiam1 on threonine residues in vitro.	Tetradecanoylphorbol Acetate	40-71	TIAM Rac1 associated GEF 1	Homo sapiens	97-102
9407095-7	1997	Moreover, acute stimulation with 100 nM phorbol 12-myristate 13-acetate was sufficient to induce Tiam1 phosphorylation in vivo, and protein kinase C could phosphorylate purified Tiam1 on threonine residues in vitro.	Tetradecanoylphorbol Acetate	40-71	TIAM Rac1 associated GEF 1	Homo sapiens	178-183
9510067-0	1997	Growth factors and phorbol-12-myristate-13-acetate modulate the follicle-stimulating hormone- and cyclic adenosine-3",5"-monophosphate-dependent regulation of 17beta-hydroxysteroid dehydrogenase type 1 expression in rat granulosa cells.	Tetradecanoylphorbol Acetate	19-50	hydroxysteroid (17-beta) dehydrogenase 1	Rattus norvegicus	159-201
9388190-0	1997	12-O-Tetradecanoylphorbol-13-acetate activates the Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of SOS involving serine phosphorylation of Shc in NIH3T3 cells.	Tetradecanoylphorbol Acetate	0-36	src homology 2 domain-containing transforming protein C1	Mus musculus	169-172
9388190-3	1997	Further analysis revealed that TPA treatment induced, dependently on protein kinase C, the mobility shift of p66(shc) in SDS-polyacrylamide gel electrophoresis, which could be prevented by treatment of the Shc immunoprecipitate with serine/threonine-specific protein phosphatase 1 (PP1) or 2A (PP2A).	Tetradecanoylphorbol Acetate	31-34	src homology 2 domain-containing transforming protein C1	Mus musculus	109-112
9388190-3	1997	Further analysis revealed that TPA treatment induced, dependently on protein kinase C, the mobility shift of p66(shc) in SDS-polyacrylamide gel electrophoresis, which could be prevented by treatment of the Shc immunoprecipitate with serine/threonine-specific protein phosphatase 1 (PP1) or 2A (PP2A).	Tetradecanoylphorbol Acetate	31-34	src homology 2 domain-containing transforming protein C1	Mus musculus	113-116
9388190-3	1997	Further analysis revealed that TPA treatment induced, dependently on protein kinase C, the mobility shift of p66(shc) in SDS-polyacrylamide gel electrophoresis, which could be prevented by treatment of the Shc immunoprecipitate with serine/threonine-specific protein phosphatase 1 (PP1) or 2A (PP2A).	Tetradecanoylphorbol Acetate	31-34	src homology 2 domain-containing transforming protein C1	Mus musculus	206-209
9388190-5	1997	Like growth factor-induced Shc phosphorylation, which leads to the association of Shc with Grb2, TPA also induced this association, but, correspondingly to the above results, the TPA-induced association was disrupted by in vitro treatment of the Shc immunoprecipitate with PP1.	Tetradecanoylphorbol Acetate	97-100	src homology 2 domain-containing transforming protein C1	Mus musculus	82-85
9388190-5	1997	Like growth factor-induced Shc phosphorylation, which leads to the association of Shc with Grb2, TPA also induced this association, but, correspondingly to the above results, the TPA-induced association was disrupted by in vitro treatment of the Shc immunoprecipitate with PP1.	Tetradecanoylphorbol Acetate	97-100	growth factor receptor bound protein 2	Mus musculus	91-95
9388190-5	1997	Like growth factor-induced Shc phosphorylation, which leads to the association of Shc with Grb2, TPA also induced this association, but, correspondingly to the above results, the TPA-induced association was disrupted by in vitro treatment of the Shc immunoprecipitate with PP1.	Tetradecanoylphorbol Acetate	97-100	src homology 2 domain-containing transforming protein C1	Mus musculus	82-85
9388190-5	1997	Like growth factor-induced Shc phosphorylation, which leads to the association of Shc with Grb2, TPA also induced this association, but, correspondingly to the above results, the TPA-induced association was disrupted by in vitro treatment of the Shc immunoprecipitate with PP1.	Tetradecanoylphorbol Acetate	179-182	src homology 2 domain-containing transforming protein C1	Mus musculus	27-30
9388190-5	1997	Like growth factor-induced Shc phosphorylation, which leads to the association of Shc with Grb2, TPA also induced this association, but, correspondingly to the above results, the TPA-induced association was disrupted by in vitro treatment of the Shc immunoprecipitate with PP1.	Tetradecanoylphorbol Acetate	179-182	src homology 2 domain-containing transforming protein C1	Mus musculus	82-85
9388190-5	1997	Like growth factor-induced Shc phosphorylation, which leads to the association of Shc with Grb2, TPA also induced this association, but, correspondingly to the above results, the TPA-induced association was disrupted by in vitro treatment of the Shc immunoprecipitate with PP1.	Tetradecanoylphorbol Acetate	179-182	growth factor receptor bound protein 2	Mus musculus	91-95
9388190-5	1997	Like growth factor-induced Shc phosphorylation, which leads to the association of Shc with Grb2, TPA also induced this association, but, correspondingly to the above results, the TPA-induced association was disrupted by in vitro treatment of the Shc immunoprecipitate with PP1.	Tetradecanoylphorbol Acetate	179-182	src homology 2 domain-containing transforming protein C1	Mus musculus	82-85
9388190-6	1997	Taken together, these results suggest that the TPA signal was fed at or upstream of Shc to activate the Ras/ERK signaling pathway involving serine phosphorylation of Shc.	Tetradecanoylphorbol Acetate	47-50	src homology 2 domain-containing transforming protein C1	Mus musculus	84-87
9388190-6	1997	Taken together, these results suggest that the TPA signal was fed at or upstream of Shc to activate the Ras/ERK signaling pathway involving serine phosphorylation of Shc.	Tetradecanoylphorbol Acetate	47-50	src homology 2 domain-containing transforming protein C1	Mus musculus	166-169
9409644-7	1997	In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period.	Tetradecanoylphorbol Acetate	146-149	CD8a molecule	Homo sapiens	13-16
9459614-9	1997	According to nuclear run-on assays the synthesis of TNF-R75 mRNA in cells treated with GM-CSF + IFN-gamma, as well as with the phorbol ester TPA, was markedly increased compared to untreated cells, indicating that the observed changes in receptor expression primarily involve altered transcription of the gene.	Tetradecanoylphorbol Acetate	141-144	TNF receptor superfamily member 1B	Homo sapiens	52-59
9398602-8	1997	HIF-1 alpha mRNA expression is increased by phorbol myristate acetate but not by anoxia or cobalt.	Tetradecanoylphorbol Acetate	44-69	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-11
9374109-7	1997	The phorbol ester phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, significantly increased MMP-9 in AM from healthy control subjects but not in those from untreated asthmatics.	Tetradecanoylphorbol Acetate	18-49	matrix metallopeptidase 9	Homo sapiens	117-122
9374109-7	1997	The phorbol ester phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, significantly increased MMP-9 in AM from healthy control subjects but not in those from untreated asthmatics.	Tetradecanoylphorbol Acetate	51-54	matrix metallopeptidase 9	Homo sapiens	117-122
9374665-4	1997	Treatments with forskolin, phorbol 12-myristate 13-acetate, staurosporine, and genistein also induced cell shape change and decreased F-actin staining and ET-1 mRNA levels.	Tetradecanoylphorbol Acetate	27-58	endothelin 1	Bos taurus	155-159
9401769-9	1997	Differentiation of cells with 1 nM phorbol ester (PMA) for 24 h resulted in a 2.4 fold increase in the cell surface level of LC1 and inhibition of the ATP-induced Ca2+ response.	Tetradecanoylphorbol Acetate	50-53	annexin A1	Homo sapiens	125-128
9344042-0	1997	Calcitriol enhancement of TPA-induced tumorigenic transformation is mediated through vitamin D receptor-dependent and -independent pathways.	Tetradecanoylphorbol Acetate	26-29	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	85-103
9379028-4	1997	Transient expression assays using CXCR4 promoter/luciferase gene reporter constructs revealed that stimulation with PMA plus ionomycin up-regulates the CXCR4 promoter activity in the A3.01 CD4+ T cell line and PBL and that a DNA fragment from -93 to +59 relative to the transcription start site contributes markedly to the basal and induced activity.	Tetradecanoylphorbol Acetate	116-119	C-X-C motif chemokine receptor 4	Homo sapiens	34-39
9379028-4	1997	Transient expression assays using CXCR4 promoter/luciferase gene reporter constructs revealed that stimulation with PMA plus ionomycin up-regulates the CXCR4 promoter activity in the A3.01 CD4+ T cell line and PBL and that a DNA fragment from -93 to +59 relative to the transcription start site contributes markedly to the basal and induced activity.	Tetradecanoylphorbol Acetate	116-119	C-X-C motif chemokine receptor 4	Homo sapiens	152-157
9349535-3	1997	Incubation of CATH.a cells with phorbol 12-myristate 13-acetate (PMA), an activator of PKC, resulted in a time- and concentration-dependent down-regulation of CRF-R1 mRNA levels.	Tetradecanoylphorbol Acetate	32-63	corticotropin releasing hormone receptor 1	Mus musculus	159-165
9349535-3	1997	Incubation of CATH.a cells with phorbol 12-myristate 13-acetate (PMA), an activator of PKC, resulted in a time- and concentration-dependent down-regulation of CRF-R1 mRNA levels.	Tetradecanoylphorbol Acetate	65-68	corticotropin releasing hormone receptor 1	Mus musculus	159-165
9409458-10	1997	In vitro stimulation by IL-1 beta, TNF alpha or phorbol 12-myristate 13-acetate induced an increase in total CD44 messenger RNA in HGF but not change in overall patterns of CD44 isoform expression.	Tetradecanoylphorbol Acetate	48-79	CD44 molecule (Indian blood group)	Homo sapiens	109-113
9406165-3	1997	Exposure of the diabetic heart to buffer containing the protein kinase C activator, phorbol myristate acetate, increased PKC beta activity in the membrane.	Tetradecanoylphorbol Acetate	84-109	protein kinase C, beta	Rattus norvegicus	121-129
9325284-10	1997	By contrast, non-chymase-producing C1 cells secrete a gelatinase B (which remains in its proform) only in response to 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	118-154	matrix metallopeptidase 9	Canis lupus familiaris	54-66
9325284-11	1997	Whereas 12-O-tetradecanoylphorbol-13-acetate stimulation of BR cells produced a approximately 15-fold increase in gelatinase B mRNA expression, dexamethasone down-regulated its expression by approximately 5-fold.	Tetradecanoylphorbol Acetate	8-44	matrix metallopeptidase 9	Canis lupus familiaris	114-126
9312201-7	1997	The effects of low-concentration PMA could be prevented by pretreatment with a PKC blocker, whereas the effects of high concentrations were only partially inhibited.	Tetradecanoylphorbol Acetate	33-36	protein kinase C, gamma	Rattus norvegicus	79-82
9363999-7	1997	Pre-application of BTP to that of TPA also resulted in significant inhibition of TPA-caused induction of epidermal ODC (23-73%, P &lt; 0.005-0.0001), and cyclo-oxygenase, in terms of prostaglandins metabolites formation (38-65%, P &lt; 0.01-0.0005), enzyme activities.	Tetradecanoylphorbol Acetate	34-37	ornithine decarboxylase, structural 1	Mus musculus	115-118
9363999-7	1997	Pre-application of BTP to that of TPA also resulted in significant inhibition of TPA-caused induction of epidermal ODC (23-73%, P &lt; 0.005-0.0001), and cyclo-oxygenase, in terms of prostaglandins metabolites formation (38-65%, P &lt; 0.01-0.0005), enzyme activities.	Tetradecanoylphorbol Acetate	81-84	ornithine decarboxylase, structural 1	Mus musculus	115-118
9378547-7	1997	c-myc can also form transcriptionally active heterodimeric complexes with the nuclear phosphoproteins p20/p22 max: thus, TPA treatment resulted in down-regulation of the p20 form of max in TUR cells.	Tetradecanoylphorbol Acetate	121-124	tubulin polymerization promoting protein family member 3	Homo sapiens	102-105
9378547-7	1997	c-myc can also form transcriptionally active heterodimeric complexes with the nuclear phosphoproteins p20/p22 max: thus, TPA treatment resulted in down-regulation of the p20 form of max in TUR cells.	Tetradecanoylphorbol Acetate	121-124	tubulin polymerization promoting protein family member 3	Homo sapiens	170-173
9300690-0	1997	Phorbol myristate acetate stimulates the dimerization of CD44 involving a cysteine in the transmembrane domain.	Tetradecanoylphorbol Acetate	0-25	CD44 molecule (Indian blood group)	Homo sapiens	57-61
9328180-1	1997	Phorbol ester-sensitive EL4 murine thymoma cells respond to phorbol 12-myristate 13-acetate with activation of ERK mitogen-activated protein kinases, synthesis of interleukin-2, and death, whereas phorbol ester-resistant variants of this cell line do not exhibit these responses.	Tetradecanoylphorbol Acetate	60-91	epilepsy 4	Mus musculus	24-27
9378778-1	1997	Induction of in vitro angiogenesis and upregulation of urokinase- and tissue type-plasminogen activator (uPA, tPA) expression are two hallmarks of vascular endothelial growth factor (VEGF) activity on cultured endothelial cells.	Tetradecanoylphorbol Acetate	110-113	vascular endothelial growth factor A	Bos taurus	147-181
9378778-1	1997	Induction of in vitro angiogenesis and upregulation of urokinase- and tissue type-plasminogen activator (uPA, tPA) expression are two hallmarks of vascular endothelial growth factor (VEGF) activity on cultured endothelial cells.	Tetradecanoylphorbol Acetate	110-113	vascular endothelial growth factor A	Bos taurus	183-187
9378778-5	1997	In both BME and BAE cells, antibodies to bFGF also decreased basal levels of cell-associated uPA activity, and completely blocked the VEGF-mediated increase in uPA and tPA expression observed in parallel cultures incubated with VEGF alone.	Tetradecanoylphorbol Acetate	168-171	vascular endothelial growth factor A	Bos taurus	134-138
9316847-2	1997	When Xenopus oocytes expressing the cloned human dopamine transporter (hDAT) were pretreated with bath-applied phorbol 12-myristate 13-acetate (PMA), a PKC activator, [3H]DA uptake decreased irreversibly in a time- and dose-dependent manner (IC50 = 22 nM; maximal inhibition = 63-85%).	Tetradecanoylphorbol Acetate	111-142	solute carrier family 6 member 3	Homo sapiens	49-69
9316847-2	1997	When Xenopus oocytes expressing the cloned human dopamine transporter (hDAT) were pretreated with bath-applied phorbol 12-myristate 13-acetate (PMA), a PKC activator, [3H]DA uptake decreased irreversibly in a time- and dose-dependent manner (IC50 = 22 nM; maximal inhibition = 63-85%).	Tetradecanoylphorbol Acetate	144-147	solute carrier family 6 member 3	Homo sapiens	49-69
9281358-7	1997	Activation of PKC by phorbol myristate acetate (PMA) also resulted in increased Il6 gene expression by control and CSF-1-primed PMo.	Tetradecanoylphorbol Acetate	21-46	colony stimulating factor 1 (macrophage)	Mus musculus	115-120
9295164-2	1997	We found that protein kinase C alp (PKCalpha) stimulated PLD1 activity in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	90-115	PDZ and LIM domain 3	Rattus norvegicus	31-34
9295164-2	1997	We found that protein kinase C alp (PKCalpha) stimulated PLD1 activity in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	90-115	protein kinase C, alpha	Rattus norvegicus	36-44
9295164-2	1997	We found that protein kinase C alp (PKCalpha) stimulated PLD1 activity in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	117-120	PDZ and LIM domain 3	Rattus norvegicus	31-34
9295164-2	1997	We found that protein kinase C alp (PKCalpha) stimulated PLD1 activity in the presence of phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	117-120	protein kinase C, alpha	Rattus norvegicus	36-44
9270008-1	1997	Deguelin, a natural product isolated from Mundulea sericea (Leguminosae), was shown previously to mediate strong inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in cell culture and to reduce the formation of preneoplastic lesions when mouse mammary glands were exposed to 7,12-dimethylbenz(a)anthracene.	Tetradecanoylphorbol Acetate	127-163	ornithine decarboxylase, structural 1	Mus musculus	203-206
9270008-1	1997	Deguelin, a natural product isolated from Mundulea sericea (Leguminosae), was shown previously to mediate strong inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in cell culture and to reduce the formation of preneoplastic lesions when mouse mammary glands were exposed to 7,12-dimethylbenz(a)anthracene.	Tetradecanoylphorbol Acetate	165-168	ornithine decarboxylase, structural 1	Mus musculus	203-206
9270008-5	1997	These results correlated with the potential of deguelin to inhibit TPA-induced mouse epidermal ODC activity.	Tetradecanoylphorbol Acetate	67-70	ornithine decarboxylase, structural 1	Mus musculus	95-98
9270008-6	1997	When applied topically as a single dose in a time range of 2 h before to 2 h after TPA treatment, deguelin (384 microg) reduced ODC induction by TPA (6.17 microg) by more than 85%.	Tetradecanoylphorbol Acetate	145-148	ornithine decarboxylase, structural 1	Mus musculus	128-131
9270008-7	1997	Time course studies indicated that deguelin (33 microg) inhibited TPA (1.17 microg)-induced ODC activity by 70% without affecting the kinetics of induction over a period of 10 h. Complete inhibition of ODC induction was observed at a dose of 330 microg of deguelin.	Tetradecanoylphorbol Acetate	66-69	ornithine decarboxylase, structural 1	Mus musculus	92-95
9270008-7	1997	Time course studies indicated that deguelin (33 microg) inhibited TPA (1.17 microg)-induced ODC activity by 70% without affecting the kinetics of induction over a period of 10 h. Complete inhibition of ODC induction was observed at a dose of 330 microg of deguelin.	Tetradecanoylphorbol Acetate	66-69	ornithine decarboxylase, structural 1	Mus musculus	202-205
9270009-3	1997	Using cultured mouse epidermal 308 cells, the steady-state levels of both 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC mRNA and c-fos were decreased by treatment with deguelin.	Tetradecanoylphorbol Acetate	74-110	ornithine decarboxylase, structural 1	Mus musculus	125-128
9270009-3	1997	Using cultured mouse epidermal 308 cells, the steady-state levels of both 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC mRNA and c-fos were decreased by treatment with deguelin.	Tetradecanoylphorbol Acetate	112-115	ornithine decarboxylase, structural 1	Mus musculus	125-128
9270009-4	1997	ODC activity was also inhibited by bullatacin and various antimitotic agents (podophyllotoxin, vinblastine, and colchicine), but only deguelin and bullatacin were active as inhibitors of ODC levels in a TPA-independent c-Myc-mediated induction system using cultured BALB/c c-MycER cells.	Tetradecanoylphorbol Acetate	203-206	ornithine decarboxylase, structural 1	Mus musculus	0-3
9280203-5	1997	The activation of ANP-C receptor by C-ANP(4-23) (a ring-deleted peptide of ANP) and C-type natriuretic peptide inhibits the mitogen-activated protein kinase activity stimulated by endothelin-3, platelet-derived growth factor and phorbol-12 myristate 13-acetate.	Tetradecanoylphorbol Acetate	229-260	natriuretic peptide C	Homo sapiens	84-110
9264383-0	1997	Upregulation of CD9 expression during TPA treatment of K562 cells.	Tetradecanoylphorbol Acetate	38-41	CD9 molecule	Homo sapiens	16-19
9264383-2	1997	We show that treatment of K562 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) which induces megakaryocytic differentiation, leads to a seven-fold increase in CD9 expression, which becomes associated with the integrin beta1, suggesting that it is functionally relevant.	Tetradecanoylphorbol Acetate	42-78	CD9 molecule	Homo sapiens	165-168
9264383-2	1997	We show that treatment of K562 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) which induces megakaryocytic differentiation, leads to a seven-fold increase in CD9 expression, which becomes associated with the integrin beta1, suggesting that it is functionally relevant.	Tetradecanoylphorbol Acetate	42-78	integrin subunit beta 1	Homo sapiens	215-229
9264383-2	1997	We show that treatment of K562 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) which induces megakaryocytic differentiation, leads to a seven-fold increase in CD9 expression, which becomes associated with the integrin beta1, suggesting that it is functionally relevant.	Tetradecanoylphorbol Acetate	80-83	CD9 molecule	Homo sapiens	165-168
9264383-2	1997	We show that treatment of K562 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) which induces megakaryocytic differentiation, leads to a seven-fold increase in CD9 expression, which becomes associated with the integrin beta1, suggesting that it is functionally relevant.	Tetradecanoylphorbol Acetate	80-83	integrin subunit beta 1	Homo sapiens	215-229
9211894-1	1997	In exploring the possible mechanisms of androgen independence of prostate-specific antigen (PSA) gene expression, we investigated the effect of elevating AP-1 by both 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment and transfection of the c-Jun expression vector in LNCaP cells.	Tetradecanoylphorbol Acetate	167-203	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	154-158
9211894-1	1997	In exploring the possible mechanisms of androgen independence of prostate-specific antigen (PSA) gene expression, we investigated the effect of elevating AP-1 by both 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment and transfection of the c-Jun expression vector in LNCaP cells.	Tetradecanoylphorbol Acetate	205-208	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	154-158
9211894-6	1997	Specifically, c-Jun inhibited the formation of AR.ARE complexes and conversely that AR-glutathione S-transferase proteins inhibited the formation of c-Jun.TPA-responsive element (TRE) complexes.	Tetradecanoylphorbol Acetate	155-158	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	149-154
9192514-4	1997	Phorbol myristate acetate (PMA) elicits a similar increase in c-fos and c-jun mRNAs, but is unable to stimulate transcription of collagenase in these cells.	Tetradecanoylphorbol Acetate	0-25	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-67
9192514-4	1997	Phorbol myristate acetate (PMA) elicits a similar increase in c-fos and c-jun mRNAs, but is unable to stimulate transcription of collagenase in these cells.	Tetradecanoylphorbol Acetate	27-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-67
9218873-1	1997	In this study, the regulatory elements involved in ICAM-1 transcriptional response to phorbol ester (12-0-tetradecanoylphorbol-13-acetate; TPA) have been investigated in the human neuroblastoma cell line, SK-N-SH.	Tetradecanoylphorbol Acetate	139-142	intercellular adhesion molecule 1	Homo sapiens	51-57
9218873-2	1997	TPA induced intercellular adhesion molecule 1 (ICAM-1) protein expression in SK-N-SH cells within 24 h of treatment as judged by indirect immunofluorescence.	Tetradecanoylphorbol Acetate	0-3	intercellular adhesion molecule 1	Homo sapiens	12-45
9218873-2	1997	TPA induced intercellular adhesion molecule 1 (ICAM-1) protein expression in SK-N-SH cells within 24 h of treatment as judged by indirect immunofluorescence.	Tetradecanoylphorbol Acetate	0-3	intercellular adhesion molecule 1	Homo sapiens	47-53
9218873-3	1997	Basal ICAM-1 mRNA levels were barely detectable in untreated SK-N-SH cells but were induced by TPA to a maximal level with 4 h and were reduced thereafter.	Tetradecanoylphorbol Acetate	95-98	intercellular adhesion molecule 1	Homo sapiens	6-12
9218873-4	1997	Analysis of the 5" promoter sequence of ICAM-1 revealed two regions that functioned equally in the TPA induction of ICAM-1 transcription.	Tetradecanoylphorbol Acetate	99-102	intercellular adhesion molecule 1	Homo sapiens	40-46
9218873-4	1997	Analysis of the 5" promoter sequence of ICAM-1 revealed two regions that functioned equally in the TPA induction of ICAM-1 transcription.	Tetradecanoylphorbol Acetate	99-102	intercellular adhesion molecule 1	Homo sapiens	116-122
9218873-8	1997	This TRE bound TPA induced specific nuclear complexes in vitro containing junD, c-jun, c-fos, and fra2 but not cAMP-responsive element binding/activating transcription factor family proteins.	Tetradecanoylphorbol Acetate	15-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-85
9315363-6	1997	Because protein kinase C (PKC), a key pro-proliferative signal transduction pathway, has been shown to play an important role in this type of global increase in growth, responsiveness to a direct cell-permeable activator of PKC (PMA, phorbol 12-myristate 13-acetate) was then measured.	Tetradecanoylphorbol Acetate	234-265	protein kinase C alpha	Bos taurus	26-29
9315363-6	1997	Because protein kinase C (PKC), a key pro-proliferative signal transduction pathway, has been shown to play an important role in this type of global increase in growth, responsiveness to a direct cell-permeable activator of PKC (PMA, phorbol 12-myristate 13-acetate) was then measured.	Tetradecanoylphorbol Acetate	234-265	protein kinase C alpha	Bos taurus	224-227
21528195-4	1997	Transfectants expressing high levels of rac-1 were blocked for TPA-, EGF- and serum-induced transformation, while transfectants expressing lower levels of rac-1 were completely blocked for EGF- and serum-induced transformation but only partially inhibited for TPA-induced transformation compared with vector control transfectants.	Tetradecanoylphorbol Acetate	63-66	Rac family small GTPase 1	Homo sapiens	40-45
9178763-6	1997	Stimulation of MMP-1 promoter by 12-O-tetradecanoyl phorbol-13-acetate and okadaic acid was differentially augmented by ETS-1 and ERGB/Fli-1, and abrogated by PU.1.	Tetradecanoylphorbol Acetate	33-70	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	135-140
9177393-5	1997	The c-jun and c-fos mRNA stimulation elicited by TPA was reduced by the PKC inhibitors, chelerythrine and staurosporine, and could not be mimicked by 4alpha-phorbol 12,13-didecanoate (a phorbol ester that fails to activate PKC), whereas the stimulation induced by EGF was diminished by the PTK inhibitor, genistein.	Tetradecanoylphorbol Acetate	49-52	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-9
9177393-5	1997	The c-jun and c-fos mRNA stimulation elicited by TPA was reduced by the PKC inhibitors, chelerythrine and staurosporine, and could not be mimicked by 4alpha-phorbol 12,13-didecanoate (a phorbol ester that fails to activate PKC), whereas the stimulation induced by EGF was diminished by the PTK inhibitor, genistein.	Tetradecanoylphorbol Acetate	49-52	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
9164962-7	1997	Exposure to PMA, a direct activator of protein kinase C that also induces an oxidative burst, inhibited CD45 in both normal and CGD neutrophils.	Tetradecanoylphorbol Acetate	12-15	protein tyrosine phosphatase receptor type C	Homo sapiens	104-108
9184651-2	1997	In this study we demonstrate that intercellular adhesion molecule-1 (ICAM-1) is dramatically (3 to 15-fold) up-regulated in human cerebromicrovascular endothelial cells (HCEC) by a 16 h exposure to the cytokine, IL-1 beta (50-200 u/ml), the phorbol ester, TPA (1-100 nM), or by simulated in vitro ischemia/reperfusion.	Tetradecanoylphorbol Acetate	256-259	intercellular adhesion molecule 1	Homo sapiens	34-67
9184651-2	1997	In this study we demonstrate that intercellular adhesion molecule-1 (ICAM-1) is dramatically (3 to 15-fold) up-regulated in human cerebromicrovascular endothelial cells (HCEC) by a 16 h exposure to the cytokine, IL-1 beta (50-200 u/ml), the phorbol ester, TPA (1-100 nM), or by simulated in vitro ischemia/reperfusion.	Tetradecanoylphorbol Acetate	256-259	intercellular adhesion molecule 1	Homo sapiens	69-75
9184651-4	1997	Both IL-1 beta- and TPA-induced expression of ICAM-1 and increased neutrophil adhesion to HCEC were inhibited by the transcriptional inhibitor, actinomycin D (AcD; 1-10 micrograms/ml), and by an anti-ICAM-1 antibody (ICAM-1 Ab).	Tetradecanoylphorbol Acetate	20-23	intercellular adhesion molecule 1	Homo sapiens	46-52
9184651-4	1997	Both IL-1 beta- and TPA-induced expression of ICAM-1 and increased neutrophil adhesion to HCEC were inhibited by the transcriptional inhibitor, actinomycin D (AcD; 1-10 micrograms/ml), and by an anti-ICAM-1 antibody (ICAM-1 Ab).	Tetradecanoylphorbol Acetate	20-23	intercellular adhesion molecule 1	Homo sapiens	200-206
9184651-4	1997	Both IL-1 beta- and TPA-induced expression of ICAM-1 and increased neutrophil adhesion to HCEC were inhibited by the transcriptional inhibitor, actinomycin D (AcD; 1-10 micrograms/ml), and by an anti-ICAM-1 antibody (ICAM-1 Ab).	Tetradecanoylphorbol Acetate	20-23	intercellular adhesion molecule 1	Homo sapiens	200-206
9184651-6	1997	The increase in surface expression of ICAM-1 and neutrophil adhesion by IL-1 beta, TPA and ischemia were significantly reduced by the cyclo-oxygenase (COX) inhibitors, indomethacin (100-300 microM) and dexamethasone (10-50 microM).	Tetradecanoylphorbol Acetate	83-86	intercellular adhesion molecule 1	Homo sapiens	38-44
9219559-7	1997	Injection of anti-GM-CSF antibodies following application of TPA in transgenic mice reduced the number of papillomas.	Tetradecanoylphorbol Acetate	61-64	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	18-24
9188861-6	1997	BCL-6 phosphorylation significantly increased in Ramos cells following stimulation with 12-o-tetradecanoylphorbol-13-acetate (TPA) or BCL-6- and erk1-transfected COS-7 cells stimulated with epidermal growth factor (EGF), and the increase of phosphorylation was inhibited by MEK1 inhibitor, PD98059.	Tetradecanoylphorbol Acetate	88-124	BCL6 transcription repressor	Homo sapiens	0-5
9188861-6	1997	BCL-6 phosphorylation significantly increased in Ramos cells following stimulation with 12-o-tetradecanoylphorbol-13-acetate (TPA) or BCL-6- and erk1-transfected COS-7 cells stimulated with epidermal growth factor (EGF), and the increase of phosphorylation was inhibited by MEK1 inhibitor, PD98059.	Tetradecanoylphorbol Acetate	126-129	BCL6 transcription repressor	Homo sapiens	0-5
9144513-0	1997	Adenosine metabolism during phorbol myristate acetate-mediated induction of HL-60 cell differentiation: changes in expression pattern of adenosine kinase, adenosine deaminase, and 5"-nucleotidase.	Tetradecanoylphorbol Acetate	28-53	adenosine deaminase	Homo sapiens	155-174
9136085-9	1997	In contrast, control or PKC activator-treated cells (phorbol 12,13-dibutyrate or 12-O-tetradecanoylphorbol-13-acetate; TPA) contracted/retracted within 5 min in response to PTH.	Tetradecanoylphorbol Acetate	81-117	protein kinase C, gamma	Rattus norvegicus	24-27
9136085-9	1997	In contrast, control or PKC activator-treated cells (phorbol 12,13-dibutyrate or 12-O-tetradecanoylphorbol-13-acetate; TPA) contracted/retracted within 5 min in response to PTH.	Tetradecanoylphorbol Acetate	119-122	protein kinase C, gamma	Rattus norvegicus	24-27
9160823-5	1997	MAPK activation was also induced by phorbol myristate acetate (PMA), confirming that a PKC-dependent pathway exists for MAPK activation in liver.	Tetradecanoylphorbol Acetate	36-61	protein kinase C, gamma	Rattus norvegicus	87-90
9160823-5	1997	MAPK activation was also induced by phorbol myristate acetate (PMA), confirming that a PKC-dependent pathway exists for MAPK activation in liver.	Tetradecanoylphorbol Acetate	63-66	protein kinase C, gamma	Rattus norvegicus	87-90
9160089-7	1997	Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis.	Tetradecanoylphorbol Acetate	0-25	integrin subunit alpha M	Homo sapiens	91-96
9160089-7	1997	Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis.	Tetradecanoylphorbol Acetate	0-25	intercellular adhesion molecule 1	Homo sapiens	114-118
9160089-7	1997	Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis.	Tetradecanoylphorbol Acetate	27-30	integrin subunit alpha M	Homo sapiens	91-96
9160089-7	1997	Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis.	Tetradecanoylphorbol Acetate	27-30	intercellular adhesion molecule 1	Homo sapiens	114-118
9195048-0	1997	Involvement of reactive oxygen species in the induction of chemokine JE/MCP-1 gene by phorbol-12-myristate-13-acetate in Balb 3T3 cells.	Tetradecanoylphorbol Acetate	86-117	chemokine (C-C motif) ligand 2	Mus musculus	72-77
9195048-1	1997	The induction of JE/MCP-1 gene by TPA was transcriptionally suppressed by antioxidants such as pyrrolidine dithiocarbamate (PDTC) or trimethylthiourea (TMTU) in Balb 3T3 cells, whereas that of other early response genes, c-fos or egr-1, was not affected by these agents.	Tetradecanoylphorbol Acetate	34-37	chemokine (C-C motif) ligand 2	Mus musculus	20-25
9075734-7	1997	Down-regulation of PKC activity by long term 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment (24 h) diminished, but did not abolish, the effect of SP on VIP-stimulated cAMP production.	Tetradecanoylphorbol Acetate	45-81	protein kinase C, alpha	Rattus norvegicus	19-22
9075734-7	1997	Down-regulation of PKC activity by long term 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment (24 h) diminished, but did not abolish, the effect of SP on VIP-stimulated cAMP production.	Tetradecanoylphorbol Acetate	83-86	protein kinase C, alpha	Rattus norvegicus	19-22
9075734-9	1997	TPA, which translocates PKC alpha, beta, and delta in lactotrophs, had a synergistic effect on cAMP formation induced by VIP, but did also, unlike SP, display cAMP rising abilities when cells were not exposed to VIP and forskolin.	Tetradecanoylphorbol Acetate	0-3	protein kinase C, alpha	Rattus norvegicus	24-33
9134496-4	1997	We examined the effects of cAMP and phorbol 12-myristate 13-acetate (PMA) on the transcription of the hCS-A and hCS-B genes.	Tetradecanoylphorbol Acetate	36-67	chorionic somatomammotropin hormone 1	Homo sapiens	102-107
9134496-4	1997	We examined the effects of cAMP and phorbol 12-myristate 13-acetate (PMA) on the transcription of the hCS-A and hCS-B genes.	Tetradecanoylphorbol Acetate	69-72	chorionic somatomammotropin hormone 1	Homo sapiens	102-107
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	integrin subunit alpha M	Homo sapiens	30-35
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	200-203	integrin subunit alpha M	Homo sapiens	30-35
9149389-5	1997	The potentiating effect of wortmannin on TPA-induced PLD activation was dose- (1-10 microM) and time-dependent (5-30 min) and was inhibited by bisindoylmalemide, an inhibitor of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	41-44	protein kinase C alpha	Bos taurus	196-199
9149389-6	1997	Furthermore, down-regulation of PKC by prolonged treatment with TPA (100 nM, 18 h) attenuated the wortmannin effect.	Tetradecanoylphorbol Acetate	64-67	protein kinase C alpha	Bos taurus	32-35
9058710-6	1997	Moreover, we found that CD44-mediated adhesion of CD34+ cells to HA could be enhanced by phorbol 12-myristate 13-acetate (PMA), the function-activating anti-CD44 monoclonal antibody H90, and cytokines such as granulocyte-monocyte colony-stimulating factor, interleukin-3 (IL-3), and stem cell factor.	Tetradecanoylphorbol Acetate	89-120	CD44 molecule (Indian blood group)	Homo sapiens	24-28
9058710-6	1997	Moreover, we found that CD44-mediated adhesion of CD34+ cells to HA could be enhanced by phorbol 12-myristate 13-acetate (PMA), the function-activating anti-CD44 monoclonal antibody H90, and cytokines such as granulocyte-monocyte colony-stimulating factor, interleukin-3 (IL-3), and stem cell factor.	Tetradecanoylphorbol Acetate	122-125	CD44 molecule (Indian blood group)	Homo sapiens	24-28
9124559-5	1997	CCK-induced activation of p90(rsk) appears to be mediated by protein kinase C (PKC), since 12-O-tetradecanoylphorbol-13-acetate increased p90(rsk) activity 5.3-fold.	Tetradecanoylphorbol Acetate	91-127	cholecystokinin	Rattus norvegicus	0-3
9250394-5	1997	As a result, PMA-induced Hsp27 phosphorylation is inhibited in SB 203580-treated HL-60 cells indicating that p38RK and MAPKAP kinase 2 are components of the PMA-induced signal transduction pathway leading to Hsp27 phosphorylation.	Tetradecanoylphorbol Acetate	13-16	MAPK activated protein kinase 2	Homo sapiens	119-134
9250394-5	1997	As a result, PMA-induced Hsp27 phosphorylation is inhibited in SB 203580-treated HL-60 cells indicating that p38RK and MAPKAP kinase 2 are components of the PMA-induced signal transduction pathway leading to Hsp27 phosphorylation.	Tetradecanoylphorbol Acetate	157-160	MAPK activated protein kinase 2	Homo sapiens	119-134
9196391-3	1997	12-O-tetradecanoyl-phorbol-13-acetate (a protein kinase C activator) and various cAMP-elevating agents, including isobutylmethylxanthine, cholera, toxin, and dibutyryl-cAMP increased melanin content per culture, tyrosinase activity and cell numbers of uveal melanocytes in a dose dependent manner.	Tetradecanoylphorbol Acetate	0-37	tyrosinase	Homo sapiens	212-222
9115586-7	1997	Characteristic codon 61 mutations in the Ha-ras gene were found in most of the papillomas and SCCs induced by DMBA and TPA in transgenic as well as nontransgenic mice.	Tetradecanoylphorbol Acetate	119-122	Harvey rat sarcoma virus oncogene	Mus musculus	41-47
9066008-4	1997	Following stimulation with phorbolester (PMA), a 3-6 fold higher expression of uPA receptor over a period of up to 5 days could be observed by fluorescent activated cell-sorting as well as by direct ligand-binding of amino-terminal fragment of uPA or vitronectin.	Tetradecanoylphorbol Acetate	41-44	vitronectin	Homo sapiens	251-262
9070225-3	1997	We therefore examined the secretion of phorbol-12-myristate-13-acetate (TPA)-stimulated newly synthesized proinsulin/insulin and total immunoreactive insulin.	Tetradecanoylphorbol Acetate	39-70	insulin II	Mus musculus	106-116
9070225-3	1997	We therefore examined the secretion of phorbol-12-myristate-13-acetate (TPA)-stimulated newly synthesized proinsulin/insulin and total immunoreactive insulin.	Tetradecanoylphorbol Acetate	72-75	insulin II	Mus musculus	106-116
9028336-8	1997	The simultaneous treatment of the cells with GM-CSF and phorbol esters such as phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu) significantly inhibited both the tyrosine phosphorylation of p85 and the activation of PI3-kinase.	Tetradecanoylphorbol Acetate	79-110	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	214-217
9028336-8	1997	The simultaneous treatment of the cells with GM-CSF and phorbol esters such as phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu) significantly inhibited both the tyrosine phosphorylation of p85 and the activation of PI3-kinase.	Tetradecanoylphorbol Acetate	112-115	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	214-217
9116146-7	1997	Treatment of sperm cells with the biologically active phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) resulted in a rapid and extensive translocation of cytosolic PKC alpha and cytosolic PKC betaI to the membrane fraction within 1 min.	Tetradecanoylphorbol Acetate	68-105	protein kinase C alpha	Bos taurus	173-206
9116146-7	1997	Treatment of sperm cells with the biologically active phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) resulted in a rapid and extensive translocation of cytosolic PKC alpha and cytosolic PKC betaI to the membrane fraction within 1 min.	Tetradecanoylphorbol Acetate	107-110	protein kinase C alpha	Bos taurus	173-206
9157598-3	1997	Differentiation of MEG-01 cells induced by 100 nM 12-O-tetradecanoylphorbol-13-acetate revealed the considerable increases in mRNA expression of rap1B, rab3B, rab4, ram and ran whereas the levels of rap2B, rhoA and rac1 decreased.	Tetradecanoylphorbol Acetate	50-86	RAB27A, member RAS oncogene family	Homo sapiens	165-168
9157598-3	1997	Differentiation of MEG-01 cells induced by 100 nM 12-O-tetradecanoylphorbol-13-acetate revealed the considerable increases in mRNA expression of rap1B, rab3B, rab4, ram and ran whereas the levels of rap2B, rhoA and rac1 decreased.	Tetradecanoylphorbol Acetate	50-86	Rac family small GTPase 1	Homo sapiens	215-219
8978286-0	1997	Antisense inhibition of c-fes proto-oncogene blocks PMA-induced macrophage differentiation in HL60 and in FDC-P1/MAC-11 cells.	Tetradecanoylphorbol Acetate	52-55	feline sarcoma oncogene	Mus musculus	24-29
8978286-8	1997	These results suggest that HL60 and FDC-P1/MAC-11 cells, when treated with phorbol 12-myristate 13-acetate, require c-fes protein expression to activate the genetic program underlying macrophage differentiation.	Tetradecanoylphorbol Acetate	75-106	feline sarcoma oncogene	Mus musculus	116-121
9067632-5	1997	Depletion of protein kinase C by PMA pre-treatment resulted in substantial inhibition of the c-fos signal.	Tetradecanoylphorbol Acetate	33-36	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	93-98
8978322-9	1997	Doxorubicin-induced changes appeared similar to the degeneration observed after treatment with a protein kinase activator (phorbol 12-myristate 13-acetate) or a serine-threonine protein phosphatase inhibitor (okadaic acid).	Tetradecanoylphorbol Acetate	123-154	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	97-111
9255603-8	1997	In contrast, PMA induced Lsk/Hyl/Matk but did not stimulate proliferation.	Tetradecanoylphorbol Acetate	13-16	megakaryocyte-associated tyrosine kinase	Homo sapiens	25-28
9255603-8	1997	In contrast, PMA induced Lsk/Hyl/Matk but did not stimulate proliferation.	Tetradecanoylphorbol Acetate	13-16	megakaryocyte-associated tyrosine kinase	Homo sapiens	29-32
9255603-8	1997	In contrast, PMA induced Lsk/Hyl/Matk but did not stimulate proliferation.	Tetradecanoylphorbol Acetate	13-16	megakaryocyte-associated tyrosine kinase	Homo sapiens	33-37
9218534-4	1997	In sharp contrast, in B cells treated with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), strong interactions between the X2 box and NF-X2 containing c-Fos were observed.	Tetradecanoylphorbol Acetate	61-97	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	165-170
9218534-4	1997	In sharp contrast, in B cells treated with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), strong interactions between the X2 box and NF-X2 containing c-Fos were observed.	Tetradecanoylphorbol Acetate	99-102	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	165-170
9218534-6	1997	Since the co-expression with a dominant negative c-Fos abolished the responsiveness to TPA, we conclude that activated transcription of the DRA gene depends on interactions between the X2 box and NF-X2, which contains c-Fos.	Tetradecanoylphorbol Acetate	87-90	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-54
9016351-2	1997	We examined the expression of functional P2UR and P2UR mRNA levels during in vitro differentiation of HL-60 cells by dibutyryl-cAMP (Bt2cAMP), which induces a granulocyte/neutrophil phenotype, or by phorbol-12-myristate-13-acetate (PMA), which induces a monocyte/macrophage phenotype.	Tetradecanoylphorbol Acetate	199-230	purinergic receptor P2Y2	Homo sapiens	41-45
9016351-2	1997	We examined the expression of functional P2UR and P2UR mRNA levels during in vitro differentiation of HL-60 cells by dibutyryl-cAMP (Bt2cAMP), which induces a granulocyte/neutrophil phenotype, or by phorbol-12-myristate-13-acetate (PMA), which induces a monocyte/macrophage phenotype.	Tetradecanoylphorbol Acetate	232-235	purinergic receptor P2Y2	Homo sapiens	41-45
9046017-2	1997	PKC activity was measured in cytosolic and particulate fractions prepared from control myocytes and those treated with either phorbol ester (phorbol 12-myristate 13-acetate, PMA) or a permeant synthetic diacylglycerol analog (1-oleoyl-2-acetylglycerol, OAG) in the absence or presence of an inhibitor of diacylglycerol kinase activity, compound R59022.	Tetradecanoylphorbol Acetate	141-172	protein kinase C, alpha	Rattus norvegicus	0-3
9046017-2	1997	PKC activity was measured in cytosolic and particulate fractions prepared from control myocytes and those treated with either phorbol ester (phorbol 12-myristate 13-acetate, PMA) or a permeant synthetic diacylglycerol analog (1-oleoyl-2-acetylglycerol, OAG) in the absence or presence of an inhibitor of diacylglycerol kinase activity, compound R59022.	Tetradecanoylphorbol Acetate	174-177	protein kinase C, alpha	Rattus norvegicus	0-3
9046017-14	1997	Incubation of the myocytes with PMA, but not OAG, resulted in translocation of PKC from the cytosolic to the particulate fraction.	Tetradecanoylphorbol Acetate	32-35	protein kinase C, alpha	Rattus norvegicus	79-82
9046017-16	1997	Results from this study show that freshly isolated adult rat cardiac ventricular myocytes contain both PKC alpha and PKC beta, and that these isoforms translocate to the particulate fraction in response to treatment with PMA, but not OAG.	Tetradecanoylphorbol Acetate	221-224	protein kinase C, beta	Rattus norvegicus	117-125
9633822-6	1997	In contrast to the results for antisense-FGF-2 transfectants, culture of antisense-FGF-1 transfectants in medium containing both FGF-2 and TPA caused a 2.6-fold reduction in transfectant doubling-time that was significantly greater than that caused by independent treatment with either FGF-2 or TPA.	Tetradecanoylphorbol Acetate	139-142	fibroblast growth factor 1	Rattus norvegicus	83-88
9633822-6	1997	In contrast to the results for antisense-FGF-2 transfectants, culture of antisense-FGF-1 transfectants in medium containing both FGF-2 and TPA caused a 2.6-fold reduction in transfectant doubling-time that was significantly greater than that caused by independent treatment with either FGF-2 or TPA.	Tetradecanoylphorbol Acetate	295-298	fibroblast growth factor 1	Rattus norvegicus	83-88
9633822-8	1997	By contrast, TPA promoted rapid activation of all three PKC isozymes.	Tetradecanoylphorbol Acetate	13-16	protein kinase C, alpha	Rattus norvegicus	56-59
9633822-9	1997	Both the TPA- and FGF-2-mediated PKC activation were prolonged and possibly involved cyclic redistribution of isozymes between soluble and particulate cell fractions.	Tetradecanoylphorbol Acetate	9-12	protein kinase C, alpha	Rattus norvegicus	33-36
9633822-11	1997	The results of these studies indicate that FGF-2 and TPA independently and conjointly modulate rat prostate-cancer-cell antisense-transfectant doubling time and suggest that effector modulation of rat prostate-cancer-cell proliferation is achieved by processes involving PKC and/or ras mediated signaling.	Tetradecanoylphorbol Acetate	53-56	protein kinase C, alpha	Rattus norvegicus	271-274
9633828-8	1997	Furthermore, we find that phorbol 12-myristate 13-acetate, which uses both protein kinase C and protein-tyrosine kinase activities to induce c-fos promoter, may share a common pathway with MC downstream of Ras.	Tetradecanoylphorbol Acetate	26-57	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	141-146
9037533-5	1996	Down-regulation of PKC by overnight pre-treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) blocked only the phorbol ester-stimulated c-fos accumulation while no effect was observed in the carbachol-induced response.	Tetradecanoylphorbol Acetate	55-91	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-145
9037533-5	1996	Down-regulation of PKC by overnight pre-treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) blocked only the phorbol ester-stimulated c-fos accumulation while no effect was observed in the carbachol-induced response.	Tetradecanoylphorbol Acetate	93-96	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-145
8968091-4	1996	VEGF/VPF mRNA was induced in skin in vivo after 12-O-tetradecanoylphorbol-13-acetate treatment.	Tetradecanoylphorbol Acetate	48-84	vascular endothelial growth factor A	Mus musculus	0-4
8968091-4	1996	VEGF/VPF mRNA was induced in skin in vivo after 12-O-tetradecanoylphorbol-13-acetate treatment.	Tetradecanoylphorbol Acetate	48-84	vascular endothelial growth factor A	Mus musculus	5-8
8977326-4	1996	Here we demonstrate that phorbol ester phorbol 12-myrislate 13-acetate (PMA), which increases tyrosine phosphorylation by stimulating protein kinase C and p21ras, can overcome the CTLA-4-mediated inhibition of T cell proliferation.	Tetradecanoylphorbol Acetate	72-75	Harvey rat sarcoma virus oncogene	Mus musculus	155-161
8977326-4	1996	Here we demonstrate that phorbol ester phorbol 12-myrislate 13-acetate (PMA), which increases tyrosine phosphorylation by stimulating protein kinase C and p21ras, can overcome the CTLA-4-mediated inhibition of T cell proliferation.	Tetradecanoylphorbol Acetate	72-75	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	180-186
9022291-0	1996	Phorbol ester (12-O-tetradecanoylphorbol 13-acetate) prevents ornithine decarboxylase inhibition and apoptosis and L1210 leukemic cells exposed to TGF-beta 1.	Tetradecanoylphorbol Acetate	15-51	ornithine decarboxylase, structural 1	Mus musculus	62-85
9022291-2	1996	The aim of the present study was to evaluate the influence of 12-O-tetradecanoylphorbol 13-acetate (TPA)--a potent ODC inducer on antiproliferative and apoptotic effects of TGF-beta 1 in L1210 leukemic cells.	Tetradecanoylphorbol Acetate	62-98	ornithine decarboxylase, structural 1	Mus musculus	115-118
9022291-10	1996	Administration of TPA simultaneously with TGF-beta 1 significantly reduced antiproliferative, apoptotic and necrotic effects of TGF-beta 1, and prevented its inhibitory action of ODC expression and activity.	Tetradecanoylphorbol Acetate	18-21	ornithine decarboxylase, structural 1	Mus musculus	179-182
9022291-11	1996	It is concluded that: down-regulation of ODC expression may be one of the early events associated with TGF-beta 1-evoked suppression of growth and apoptosis; ODC is involved in the mechanism of protective action of TPA on TGF-beta 1-related growth inhibition of L1210 leukemic cells.	Tetradecanoylphorbol Acetate	215-218	ornithine decarboxylase, structural 1	Mus musculus	41-44
9022291-11	1996	It is concluded that: down-regulation of ODC expression may be one of the early events associated with TGF-beta 1-evoked suppression of growth and apoptosis; ODC is involved in the mechanism of protective action of TPA on TGF-beta 1-related growth inhibition of L1210 leukemic cells.	Tetradecanoylphorbol Acetate	215-218	ornithine decarboxylase, structural 1	Mus musculus	158-161
8920963-6	1996	When stromal cells were isolated and cultured, they produced significant amounts of HGF, which was further stimulated by prostaglandin E2, 12-O-tetradecanoylphorbol-13-acetate, and dibutyryl cyclic AMP, but not by testosterone.	Tetradecanoylphorbol Acetate	139-175	hepatocyte growth factor	Rattus norvegicus	84-87
8950029-4	1996	PMA, but not Ara-C or ceramides, activated ERK MAPKS, in Jurkat and EL4.	Tetradecanoylphorbol Acetate	0-3	epilepsy 4	Mus musculus	68-71
8895748-3	1996	RARalpha was slightly reduced in papillomas promoted with 12-O-tetradecanoylphorbol-13-acetate (low risk) and markedly decreased or absent in papillomas promoted by mezerein (high risk).	Tetradecanoylphorbol Acetate	58-94	retinoic acid receptor, alpha	Mus musculus	0-8
8895748-10	1996	Both RARalpha and RARgamma are down-regulated in cultured keratinocytes by 12-O-tetradecanoylphorbol-13-acetate, further implicating PKC in the regulation of retinoid receptors.	Tetradecanoylphorbol Acetate	75-111	retinoic acid receptor, alpha	Mus musculus	5-13
8895748-10	1996	Both RARalpha and RARgamma are down-regulated in cultured keratinocytes by 12-O-tetradecanoylphorbol-13-acetate, further implicating PKC in the regulation of retinoid receptors.	Tetradecanoylphorbol Acetate	75-111	retinoic acid receptor, gamma	Mus musculus	18-26
8930402-2	1996	We report that TPA-treated K562 cells also express higher levels of FLI-1/ERGB, a member of the ETS family of transcription factors.	Tetradecanoylphorbol Acetate	15-18	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	68-73
8930402-3	1996	Furthermore, introduction of a retroviral construct expressing human FLI-1/ERGB into K562 cells induces changes similar to those seen following TPA treatment, including increased adherence to the surface of the culture vessel and altered size and morphology.	Tetradecanoylphorbol Acetate	144-147	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	69-74
8917124-6	1996	The addition of DHA to the diet reduced significantly the edema formation and the MPO activity 24 h after TPA challenge.	Tetradecanoylphorbol Acetate	106-109	myeloperoxidase	Mus musculus	82-85
8922474-5	1996	MAbs against the dUTPase reacted with a protein of approximately 31 kDa in 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-stimulated B cells harbouring either type 1 or type 2 EBV.	Tetradecanoylphorbol Acetate	75-112	Deoxyuridine triphosphatase	Drosophila melanogaster	17-24
8922474-5	1996	MAbs against the dUTPase reacted with a protein of approximately 31 kDa in 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-stimulated B cells harbouring either type 1 or type 2 EBV.	Tetradecanoylphorbol Acetate	114-117	Deoxyuridine triphosphatase	Drosophila melanogaster	17-24
8938544-5	1996	Phorbol 12-myristate 13-acetate stimulated sustained high levels of intercellular adhesion molecule-1 protein, whereas the corresponding mRNA response was biphasic, peaking at 3 h. Actinomycin D blocked the stimulatory mRNA phase, suggesting that de novo transcription was induced.	Tetradecanoylphorbol Acetate	0-31	intercellular adhesion molecule 1	Homo sapiens	68-101
8938544-8	1996	The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1.	Tetradecanoylphorbol Acetate	109-140	intercellular adhesion molecule 1	Homo sapiens	72-105
8948021-6	1996	Proper crosslinking of TCR together with CD4, CD8, or LFA-1 inhibits the death, and its inhibitory activity is mimicked by proper combinations of ionomycin, a calcium ionophore, and phorbol myristate acetate (PMA), a protein kinase C (PKC) activator.	Tetradecanoylphorbol Acetate	182-207	CD8a molecule	Homo sapiens	46-49
8948021-8	1996	Transient stimulation with the combinations of ionomycin and PMA induces differentiation and commitment of isolated DP thymocytes to the CD4 or CD8 T cell lineage in suspension cultures.	Tetradecanoylphorbol Acetate	61-64	CD8a molecule	Homo sapiens	144-147
8824244-5	1996	Phosphorylation of Galpha12 and Galpha13 could be mimicked by phorbol 12-myristate 13-acetate, and thrombin-induced phosphorylation was inhibited by the protein kinase C inhibitor calphostin C indicating an involvement of protein kinase C in Galpha12/13 phosphorylation induced by thrombin in human platelets.	Tetradecanoylphorbol Acetate	62-93	G protein subunit alpha 13	Homo sapiens	32-40
8824244-7	1996	Among the protein knase C isoforms tested, protein kinase C beta, delta, and epsilon were most effective in promoting phosphorylation of Galpha12 and Galpha13 in a phorbol 12-myristate 13-acetate-dependent manner.	Tetradecanoylphorbol Acetate	164-195	G protein subunit alpha 13	Homo sapiens	150-158
8839832-0	1996	A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages.	Tetradecanoylphorbol Acetate	94-122	TNF receptor superfamily member 8	Homo sapiens	10-14
8839832-1	1996	We identified and cloned cDNAs for two novel CD30 mRNAs of 2.3 kb that are induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in the human myeloid leukemia cell line HL-60.	Tetradecanoylphorbol Acetate	86-122	TNF receptor superfamily member 8	Homo sapiens	45-49
8839832-1	1996	We identified and cloned cDNAs for two novel CD30 mRNAs of 2.3 kb that are induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in the human myeloid leukemia cell line HL-60.	Tetradecanoylphorbol Acetate	124-127	TNF receptor superfamily member 8	Homo sapiens	45-49
8839832-7	1996	Northern blots detected the expression of CD30v transcripts only in the lung and the TPA-stimulated HL-60 cell line.	Tetradecanoylphorbol Acetate	85-88	TNF receptor superfamily member 8	Homo sapiens	42-46
8839832-9	1996	Immunoblotting analysis with HCD30C1, a rabbit polyclonal antibody raised against the cytoplasmic domain of CD30 protein, detected proteins with an apparent Mr 25 kD expressed in TPA-stimulated HL-60 and COS-7 cells that were transfected with both types of CD30v cDNAs.	Tetradecanoylphorbol Acetate	179-182	TNF receptor superfamily member 8	Homo sapiens	30-34
8839832-9	1996	Immunoblotting analysis with HCD30C1, a rabbit polyclonal antibody raised against the cytoplasmic domain of CD30 protein, detected proteins with an apparent Mr 25 kD expressed in TPA-stimulated HL-60 and COS-7 cells that were transfected with both types of CD30v cDNAs.	Tetradecanoylphorbol Acetate	179-182	TNF receptor superfamily member 8	Homo sapiens	257-262
8813135-8	1996	WAF1/CIP1/p21 expression increased in response to TPA promotion in all HK1-p53 transgenic genotypes regardless of p53 status.	Tetradecanoylphorbol Acetate	50-53	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	0-4
8813135-8	1996	WAF1/CIP1/p21 expression increased in response to TPA promotion in all HK1-p53 transgenic genotypes regardless of p53 status.	Tetradecanoylphorbol Acetate	50-53	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	5-9
8813135-8	1996	WAF1/CIP1/p21 expression increased in response to TPA promotion in all HK1-p53 transgenic genotypes regardless of p53 status.	Tetradecanoylphorbol Acetate	50-53	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	10-13
8813135-8	1996	WAF1/CIP1/p21 expression increased in response to TPA promotion in all HK1-p53 transgenic genotypes regardless of p53 status.	Tetradecanoylphorbol Acetate	50-53	hexokinase 1	Mus musculus	71-74
8813135-9	1996	However, in HK1-p53 null genotypes, although TPA-induced, p53-independent WAF1/CIP1/p21 expression was observed, no large increase in expression was associated with the observed paradoxical tumorigenesis block.	Tetradecanoylphorbol Acetate	45-48	hexokinase 1	Mus musculus	12-15
8813135-9	1996	However, in HK1-p53 null genotypes, although TPA-induced, p53-independent WAF1/CIP1/p21 expression was observed, no large increase in expression was associated with the observed paradoxical tumorigenesis block.	Tetradecanoylphorbol Acetate	45-48	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	74-78
8813135-9	1996	However, in HK1-p53 null genotypes, although TPA-induced, p53-independent WAF1/CIP1/p21 expression was observed, no large increase in expression was associated with the observed paradoxical tumorigenesis block.	Tetradecanoylphorbol Acetate	45-48	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	79-83
8813135-9	1996	However, in HK1-p53 null genotypes, although TPA-induced, p53-independent WAF1/CIP1/p21 expression was observed, no large increase in expression was associated with the observed paradoxical tumorigenesis block.	Tetradecanoylphorbol Acetate	45-48	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	84-87
8898915-4	1996	Three isoforms of MRP-14 were markedly phosphorylated in the membrane and in the cytosol upon activation with extracellular calcium-dependent stimuli, such as opsonized zymosan, the calcium ionophore A23187, N-formylmethionylleucylphenylalanine in the presence of cytochalasin B and arachidonic acid, or upon extracellular calcium-independent stimulation (PMA).	Tetradecanoylphorbol Acetate	356-359	S100 calcium binding protein A9	Homo sapiens	18-24
8921428-4	1996	T cells secreted IgG2-SF together with IL-2 and IFN-gamma, after activation with a combination of anti-CD2, anti-CD28 and phorbol myristate acetate (Th1-like activation).	Tetradecanoylphorbol Acetate	122-147	negative elongation factor complex member C/D	Homo sapiens	149-152
8943722-7	1996	However, IL-1 beta, IL-2 and TNF-alpha mRNA levels of lymph node cells from CD4- mice could be upregulated by phorbol myristate acetate in vitro.	Tetradecanoylphorbol Acetate	110-135	CD4 antigen	Mus musculus	76-79
8858934-6	1996	Activation of protein kinase C by the phorbol esters phorbol 12,13-dibutyrate and phorbol 12-myristate 13-acetate increased production of the soluble form of the amyloid precursor protein dramatically.	Tetradecanoylphorbol Acetate	82-113	amyloid beta precursor protein	Rattus norvegicus	162-187
8938586-6	1996	Incubation with 12-O-tetradecanoyl-phorbol-13-acetate, which activates protein kinase C (PKC), induces clusterin mRNA, while chelerythrine, an inhibitor of PKC, represses clusterin gene expression, suggesting that the clusterin gene responds to signalling pathways involving PKC.	Tetradecanoylphorbol Acetate	16-53	clusterin	Canis lupus familiaris	103-112
8938586-6	1996	Incubation with 12-O-tetradecanoyl-phorbol-13-acetate, which activates protein kinase C (PKC), induces clusterin mRNA, while chelerythrine, an inhibitor of PKC, represses clusterin gene expression, suggesting that the clusterin gene responds to signalling pathways involving PKC.	Tetradecanoylphorbol Acetate	16-53	clusterin	Canis lupus familiaris	171-180
8938586-6	1996	Incubation with 12-O-tetradecanoyl-phorbol-13-acetate, which activates protein kinase C (PKC), induces clusterin mRNA, while chelerythrine, an inhibitor of PKC, represses clusterin gene expression, suggesting that the clusterin gene responds to signalling pathways involving PKC.	Tetradecanoylphorbol Acetate	16-53	clusterin	Canis lupus familiaris	171-180
8863847-8	1996	A complete down-regulation of PKC-alpha and PKC-delta was seen after 24-hr treatment with 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	90-126	protein kinase C, alpha	Rattus norvegicus	30-39
9121495-4	1996	In contrast, TPA treatment stimulated expression of a human GnRH-luciferase reporter construct, correlating with the expression of the protoon-cogenes c-fos and c-jun.	Tetradecanoylphorbol Acetate	13-16	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	151-156
9121495-4	1996	In contrast, TPA treatment stimulated expression of a human GnRH-luciferase reporter construct, correlating with the expression of the protoon-cogenes c-fos and c-jun.	Tetradecanoylphorbol Acetate	13-16	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	161-166
9121495-5	1996	TPA stimulation of the human GnRH gene is mediated by a consensus AP-1 site located at -402 to -396 bp, TGACTCA, which specifically binds c-fos and c-jun in Gn11 and NLT cells and recombinant c-jun in gel mobility shift studies.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-143
8899846-3	1996	The influence of apigenin in DMSO, A/D (4:1), and propylene glycol/DMSO (PG/D, 4:1) on 12-O-tetradecanoylphorbol-13 acetate (TPA) induced ornithine decarboxylase (ODC) activity was compared.	Tetradecanoylphorbol Acetate	87-123	ornithine decarboxylase, structural 1	Mus musculus	138-161
8899846-8	1996	Inhibition of TPA-induced ODC by apigenin in three vehicles was in the order of DMSO &gt; A/D &gt; PG/D.	Tetradecanoylphorbol Acetate	14-17	ornithine decarboxylase, structural 1	Mus musculus	26-29
8899846-9	1996	TPA-induced ODC in dorsal skin was not inhibited by apigenin delivered from abdominal skin.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	12-15
8899846-12	1996	CONCLUSIONS: (a) The short-term TPA-induced ODC was validated for evaluating topical formulations of apigenin.	Tetradecanoylphorbol Acetate	32-35	ornithine decarboxylase, structural 1	Mus musculus	44-47
8798479-1	1996	We previously demonstrated that glia maturation factor (GMF), a 17-kDa brain protein, can be phosphorylated in test tube by several protein kinases, and that endogenous GMF is rapidly phosphorylated upon stimulation of astrocytes by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	233-264	glia maturation factor beta	Homo sapiens	32-54
8798479-1	1996	We previously demonstrated that glia maturation factor (GMF), a 17-kDa brain protein, can be phosphorylated in test tube by several protein kinases, and that endogenous GMF is rapidly phosphorylated upon stimulation of astrocytes by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	233-264	glia maturation factor beta	Homo sapiens	56-59
8798479-1	1996	We previously demonstrated that glia maturation factor (GMF), a 17-kDa brain protein, can be phosphorylated in test tube by several protein kinases, and that endogenous GMF is rapidly phosphorylated upon stimulation of astrocytes by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	233-264	glia maturation factor beta	Homo sapiens	169-172
8836156-4	1996	Treatment of the cells for 12 or 6 h with, respectively, 0.5 mM 8-CPT-cAMP or 1 microM PMA produced a maximal decrease of about 60% in HSL mRNA.	Tetradecanoylphorbol Acetate	87-90	lipase, hormone sensitive	Mus musculus	135-138
8798441-6	1996	Treatment with phorbol 12-myristate 13-acetate (PMA) led to an increase in both the amount of phosphorylated CREB and the bcl-2 promoter activity.	Tetradecanoylphorbol Acetate	48-51	cAMP responsive element binding protein 1	Homo sapiens	109-113
8816913-1	1996	Studies on the link between cellular signalling and cell cycle control at the G2 checkpoint have shown that, in HeLa cells, epidermal growth factor (EGF) and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) rapidly inhibit the G2-M transition by preventing the key component of mitosis-promoting factor (MPF), p34cdc2, from expressing protein kinase activity.	Tetradecanoylphorbol Acetate	176-212	mesothelin	Homo sapiens	290-314
8816913-1	1996	Studies on the link between cellular signalling and cell cycle control at the G2 checkpoint have shown that, in HeLa cells, epidermal growth factor (EGF) and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) rapidly inhibit the G2-M transition by preventing the key component of mitosis-promoting factor (MPF), p34cdc2, from expressing protein kinase activity.	Tetradecanoylphorbol Acetate	176-212	mesothelin	Homo sapiens	316-319
8943800-8	1996	While treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) reproduced the effect of All on 3 beta-HSD expression, TPA failed to reproduce the effects of All on P450c17 because it caused a marked decrease in P450c17 expression.	Tetradecanoylphorbol Acetate	59-62	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	96-106
8910867-5	1996	After topical administration, this compound was effective as an inhibitor of oedema and myeloperoxidase activity in the 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear oedema and significantly reduced the PGE2 content and ear oedema in the arachidonic acid-induced response.	Tetradecanoylphorbol Acetate	120-156	myeloperoxidase	Mus musculus	88-103
8910867-5	1996	After topical administration, this compound was effective as an inhibitor of oedema and myeloperoxidase activity in the 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear oedema and significantly reduced the PGE2 content and ear oedema in the arachidonic acid-induced response.	Tetradecanoylphorbol Acetate	158-161	myeloperoxidase	Mus musculus	88-103
8947589-7	1996	The differentiation of HL-60 cells induced by all-trans retinoic acid, dimethyl sulfoxide or phorbol-12-myristate 13-acetate was also enhanced by ethacrynic acid with increasing NBT-reducing and lysozyme activities and the expression of CD11b or CD14 surface antigen.	Tetradecanoylphorbol Acetate	93-124	integrin subunit alpha M	Homo sapiens	237-242
8898346-8	1996	This negative feed-back of PKC on GnRH-Induced PLC and PLA2 activities was reversed when PKC was either down regulated after long TPA treatments or inhibited by the PKC inhibitors, staurosporine or GF109203X.	Tetradecanoylphorbol Acetate	130-133	phospholipase A2 group IIA	Homo sapiens	55-59
8702711-9	1996	Our data thus show that the glucagon-like peptide-1 receptor can be phosphorylated in response to phorbol 12-myristate 13-acetate on four different sites within the cytoplasmic tail.	Tetradecanoylphorbol Acetate	98-129	glucagon-like peptide 1 receptor	Cricetulus griseus	28-60
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	retinoid X receptor alpha	Homo sapiens	185-205
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	retinoid X receptor alpha	Homo sapiens	207-210
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	retinoid X receptor alpha	Homo sapiens	251-254
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	retinoid X receptor alpha	Homo sapiens	251-254
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	retinoid X receptor alpha	Homo sapiens	251-254
8753812-5	1996	It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway.	Tetradecanoylphorbol Acetate	131-134	retinoid X receptor alpha	Homo sapiens	251-254
8877408-4	1996	Incubation of cells with 20 nM phorbol 12-myristate 13-acetate (PMA) for 6 h caused down-regulation of protein kinase C (PKC) alpha and beta isozymes, whereas it had no effect on PKC delta, epsilon and zeta isozymes.	Tetradecanoylphorbol Acetate	31-62	protein kinase C, alpha	Rattus norvegicus	103-131
8877408-4	1996	Incubation of cells with 20 nM phorbol 12-myristate 13-acetate (PMA) for 6 h caused down-regulation of protein kinase C (PKC) alpha and beta isozymes, whereas it had no effect on PKC delta, epsilon and zeta isozymes.	Tetradecanoylphorbol Acetate	64-67	protein kinase C, alpha	Rattus norvegicus	103-131
8830802-4	1996	Furthermore chlorophyllin also exhibited a dose-dependent inhibition on 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity of 3T3 fibroblast cells at the same concentrations.	Tetradecanoylphorbol Acetate	72-109	ornithine decarboxylase, structural 1	Mus musculus	124-147
8830802-4	1996	Furthermore chlorophyllin also exhibited a dose-dependent inhibition on 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity of 3T3 fibroblast cells at the same concentrations.	Tetradecanoylphorbol Acetate	72-109	ornithine decarboxylase, structural 1	Mus musculus	149-152
8830802-4	1996	Furthermore chlorophyllin also exhibited a dose-dependent inhibition on 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity of 3T3 fibroblast cells at the same concentrations.	Tetradecanoylphorbol Acetate	111-114	ornithine decarboxylase, structural 1	Mus musculus	124-147
8830802-4	1996	Furthermore chlorophyllin also exhibited a dose-dependent inhibition on 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity of 3T3 fibroblast cells at the same concentrations.	Tetradecanoylphorbol Acetate	111-114	ornithine decarboxylase, structural 1	Mus musculus	149-152
9389195-6	1996	Pre-treatment with PKC activator PMA (phorbol myristate acetate) for 24 h (PKC downregulation) significantly attenuated ET-1-induced MAPK activation.	Tetradecanoylphorbol Acetate	33-36	endothelin-1	Oryctolagus cuniculus	120-124
9389195-6	1996	Pre-treatment with PKC activator PMA (phorbol myristate acetate) for 24 h (PKC downregulation) significantly attenuated ET-1-induced MAPK activation.	Tetradecanoylphorbol Acetate	38-63	endothelin-1	Oryctolagus cuniculus	120-124
8663346-8	1996	DEX and PMA also decrease GH-induced tyrosyl phosphorylation of GHR and JAK2 with a magnitude and time course correlating with that of inhibition of GH binding.	Tetradecanoylphorbol Acetate	8-11	tyrosine-protein kinase JAK2	Cricetulus griseus	72-76
8663346-9	1996	DEX- and PMA-induced reductions of GH binding are also observed in a Chinese hamster ovary (CHO) cell line stably transfected with a rat liver GHR cDNA, further arguing that DEX and PMA act post-translationally on GHR.	Tetradecanoylphorbol Acetate	9-12	growth hormone receptor	Rattus norvegicus	143-146
8663346-9	1996	DEX- and PMA-induced reductions of GH binding are also observed in a Chinese hamster ovary (CHO) cell line stably transfected with a rat liver GHR cDNA, further arguing that DEX and PMA act post-translationally on GHR.	Tetradecanoylphorbol Acetate	9-12	growth hormone receptor	Rattus norvegicus	214-217
8663346-9	1996	DEX- and PMA-induced reductions of GH binding are also observed in a Chinese hamster ovary (CHO) cell line stably transfected with a rat liver GHR cDNA, further arguing that DEX and PMA act post-translationally on GHR.	Tetradecanoylphorbol Acetate	182-185	growth hormone receptor	Rattus norvegicus	143-146
8663346-9	1996	DEX- and PMA-induced reductions of GH binding are also observed in a Chinese hamster ovary (CHO) cell line stably transfected with a rat liver GHR cDNA, further arguing that DEX and PMA act post-translationally on GHR.	Tetradecanoylphorbol Acetate	182-185	growth hormone receptor	Rattus norvegicus	214-217
8691508-2	1996	EL-4 cells were stimulated with phorbol 12-myristate 12-acetate (PMA) in the presence of mycotoxins at various concentrations for 5 d and culture supernatants were analyzed for interleukins (IL) IL-2 and IL-5 by enzyme-linked immunosorbent assay (ELISA).	Tetradecanoylphorbol Acetate	65-68	epilepsy 4	Mus musculus	0-4
8764366-4	1996	Further, U-73122 suppressed interleukin-8, N-formylmethionyl-leucyl-phenylalanine and PMA-stimulated up-regulation of the beta 2-integrin, Mac-1 (CD11b/CD18), on the PMN surface (IC50 &lt; 1.3 microM).	Tetradecanoylphorbol Acetate	86-89	integrin subunit alpha M	Homo sapiens	139-144
8764366-4	1996	Further, U-73122 suppressed interleukin-8, N-formylmethionyl-leucyl-phenylalanine and PMA-stimulated up-regulation of the beta 2-integrin, Mac-1 (CD11b/CD18), on the PMN surface (IC50 &lt; 1.3 microM).	Tetradecanoylphorbol Acetate	86-89	integrin subunit alpha M	Homo sapiens	146-151
8837013-4	1996	A transient induction of both c-fos and c-jun mRNAs by TPA was observed in both cell populations, together with an associated suppression of BSP mRNA in the fetal rat calvarial cells.	Tetradecanoylphorbol Acetate	55-58	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-35
8875602-2	1996	This premise was examined in guinea pigs, using 12-O-tetradecanoyl-phorbol 13-acetate (TPA) to stimulate bicarbonate production in the perfused duodenum in vivo, and to activate PKC in isolated duodenal enterocytes.	Tetradecanoylphorbol Acetate	87-90	Prkca	Cavia porcellus	178-181
8875602-6	1996	TPA (10(-7) mol.kg-1) caused a time-dependent translocation of the cytosolic, lipid-dependent activity of PKC into the particulate fraction.	Tetradecanoylphorbol Acetate	0-3	Prkca	Cavia porcellus	106-109
8652819-3	1996	Using ultrastructural and confocal laser scanning microscopic (CLSM) image analysis, we observed that treatment of Dami cells, a human megakaryocytic cell line, with phorbol myristate acetate (PMA) induces the accumulation of PAI-1 and Vn in intracellular storage vacuoles that contain other alpha-granule proteins such as von Willebrand factor.	Tetradecanoylphorbol Acetate	166-191	vitronectin	Homo sapiens	236-238
8652819-3	1996	Using ultrastructural and confocal laser scanning microscopic (CLSM) image analysis, we observed that treatment of Dami cells, a human megakaryocytic cell line, with phorbol myristate acetate (PMA) induces the accumulation of PAI-1 and Vn in intracellular storage vacuoles that contain other alpha-granule proteins such as von Willebrand factor.	Tetradecanoylphorbol Acetate	193-196	vitronectin	Homo sapiens	236-238
8662851-3	1996	Phorbol 12-myristate 13-acetate treatment enhanced high potassium-induced [3H]-norepinephrine release, and a 28-kDa protein recognized by an anti-SNAP-25 antibody was phosphorylated on Ser residues.	Tetradecanoylphorbol Acetate	0-31	synaptosome associated protein 25	Rattus norvegicus	146-153
8761946-2	1996	Since fos/jun and steroid hormones interact to regulate gene expression, we asked whether phorbol-12-myristate-13-acetate (PMA), which stimulates binding of fos/jun to AP1 sites, transactivates the avian beta 3 integrin gene and, if so, does the phorbol ester modulate 1,25(OH)2D3 induction of the gene.	Tetradecanoylphorbol Acetate	90-121	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-160
8761946-2	1996	Since fos/jun and steroid hormones interact to regulate gene expression, we asked whether phorbol-12-myristate-13-acetate (PMA), which stimulates binding of fos/jun to AP1 sites, transactivates the avian beta 3 integrin gene and, if so, does the phorbol ester modulate 1,25(OH)2D3 induction of the gene.	Tetradecanoylphorbol Acetate	90-121	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	168-171
8761946-2	1996	Since fos/jun and steroid hormones interact to regulate gene expression, we asked whether phorbol-12-myristate-13-acetate (PMA), which stimulates binding of fos/jun to AP1 sites, transactivates the avian beta 3 integrin gene and, if so, does the phorbol ester modulate 1,25(OH)2D3 induction of the gene.	Tetradecanoylphorbol Acetate	123-126	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	6-9
8761946-2	1996	Since fos/jun and steroid hormones interact to regulate gene expression, we asked whether phorbol-12-myristate-13-acetate (PMA), which stimulates binding of fos/jun to AP1 sites, transactivates the avian beta 3 integrin gene and, if so, does the phorbol ester modulate 1,25(OH)2D3 induction of the gene.	Tetradecanoylphorbol Acetate	123-126	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-160
8761946-2	1996	Since fos/jun and steroid hormones interact to regulate gene expression, we asked whether phorbol-12-myristate-13-acetate (PMA), which stimulates binding of fos/jun to AP1 sites, transactivates the avian beta 3 integrin gene and, if so, does the phorbol ester modulate 1,25(OH)2D3 induction of the gene.	Tetradecanoylphorbol Acetate	123-126	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	168-171
8964847-8	1996	Whereas treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) reproduced the effect of AII on 3 beta-HSD expression, TPA failed to reproduce the effects of AII on P450c17 and P450scc and even resulted in a marked decrease in expression of P450c17.	Tetradecanoylphorbol Acetate	61-64	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	98-108
8632150-2	1996	NGF induced the accumulation of hypophosphorylated pRB within 30 min and the level peaked after 12 h. Viral Kiras, cyclic AMP (cAMP), and 12-O-tetradecanoylphorbol 13-acetate (TPA) also induced the hypophosphorylation of pRB, but epidermal growth factor and interleukin-6 did not.	Tetradecanoylphorbol Acetate	138-174	RB transcriptional corepressor 1	Rattus norvegicus	51-54
8632150-2	1996	NGF induced the accumulation of hypophosphorylated pRB within 30 min and the level peaked after 12 h. Viral Kiras, cyclic AMP (cAMP), and 12-O-tetradecanoylphorbol 13-acetate (TPA) also induced the hypophosphorylation of pRB, but epidermal growth factor and interleukin-6 did not.	Tetradecanoylphorbol Acetate	138-174	RB transcriptional corepressor 1	Rattus norvegicus	221-224
8632150-2	1996	NGF induced the accumulation of hypophosphorylated pRB within 30 min and the level peaked after 12 h. Viral Kiras, cyclic AMP (cAMP), and 12-O-tetradecanoylphorbol 13-acetate (TPA) also induced the hypophosphorylation of pRB, but epidermal growth factor and interleukin-6 did not.	Tetradecanoylphorbol Acetate	176-179	RB transcriptional corepressor 1	Rattus norvegicus	51-54
8667229-1	1996	When rat peritoneal macrophages were incubated in medium containing 12-O-tetradecanoylphorbol 13-acetate (TPA), a protein kinase C activator, production of cell-associated platelet-activating factor (PAF) and extracellular prostaglandin E2 (PGE2) increased.	Tetradecanoylphorbol Acetate	68-104	PCNA clamp associated factor	Rattus norvegicus	156-204
8667229-1	1996	When rat peritoneal macrophages were incubated in medium containing 12-O-tetradecanoylphorbol 13-acetate (TPA), a protein kinase C activator, production of cell-associated platelet-activating factor (PAF) and extracellular prostaglandin E2 (PGE2) increased.	Tetradecanoylphorbol Acetate	106-109	PCNA clamp associated factor	Rattus norvegicus	156-204
8667229-2	1996	In the presence of the cyclooxygenase inhibitor indomethacin, TPA-induced PAF production was further enhanced dose-dependently in accordance with decrease of PGE2 levels.	Tetradecanoylphorbol Acetate	62-65	PCNA clamp associated factor	Rattus norvegicus	74-77
8667229-4	1996	Other cyclooxygenase inhibitors such as naproxen and ibuprofen also enhanced TPA-stimulated PAF production in accordance with inhibition of PGE2 production.	Tetradecanoylphorbol Acetate	77-80	PCNA clamp associated factor	Rattus norvegicus	92-95
8625537-9	1996	Similar but transient inhibition of most T-cell products (IL-2, IL-3, IL-4, IL-5, IL-10, TNF-beta and GM-CSF) was noted in the PMA/ionomycin-containing cultures.	Tetradecanoylphorbol Acetate	127-130	interleukin 10	Homo sapiens	82-87
8625537-9	1996	Similar but transient inhibition of most T-cell products (IL-2, IL-3, IL-4, IL-5, IL-10, TNF-beta and GM-CSF) was noted in the PMA/ionomycin-containing cultures.	Tetradecanoylphorbol Acetate	127-130	lymphotoxin alpha	Homo sapiens	89-97
8621804-1	1996	Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed.	Tetradecanoylphorbol Acetate	172-175	intercellular adhesion molecule 1	Homo sapiens	33-65
8621804-1	1996	Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed.	Tetradecanoylphorbol Acetate	172-175	intercellular adhesion molecule 1	Homo sapiens	67-73
8621804-1	1996	Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed.	Tetradecanoylphorbol Acetate	177-208	intercellular adhesion molecule 1	Homo sapiens	33-65
8621804-1	1996	Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed.	Tetradecanoylphorbol Acetate	177-208	intercellular adhesion molecule 1	Homo sapiens	67-73
8612293-3	1996	Hemocyte aggregation, stimulated by phorbol myristate acetate or lipopolysaccharide (LPS), was prevented by hemolin in a dose-dependent fashion, but hemolin did not disrupt aggregates once they had been formed.	Tetradecanoylphorbol Acetate	36-61	hemolin	Bombyx mori	108-115
8732291-5	1996	The expression of lipocortin 1 and its mRNA increased during TPA-induced differentiation of U937 cells to a maximum of 1.9 fold and 8.2 fold, respectively, after 48 h. Both the protein and the mRNA levels decreased after 48 h. 3.	Tetradecanoylphorbol Acetate	61-64	annexin A1	Homo sapiens	18-30
8732291-6	1996	TPA caused the translocation of lipocortin 1 from the cytosol to the membrane of U937 cells in a time-dependent manner, as determined by Western blot analysis.	Tetradecanoylphorbol Acetate	0-3	annexin A1	Homo sapiens	32-44
8732291-8	1996	After 48 h of TPA treatment, 82.6 +/- 6.5% of lipocortin 1 was present in the membrane fraction compared to 41.6 +/- 1.7% in untreated cells.	Tetradecanoylphorbol Acetate	14-17	annexin A1	Homo sapiens	46-58
8701784-4	1996	In these cells, 12-0-tetra-decanoylphorbol-13-acetate (TPA) increased c-fos and c-jun expression as did estradiol.	Tetradecanoylphorbol Acetate	55-58	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	70-75
8701784-4	1996	In these cells, 12-0-tetra-decanoylphorbol-13-acetate (TPA) increased c-fos and c-jun expression as did estradiol.	Tetradecanoylphorbol Acetate	55-58	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-85
8925892-2	1996	When concanavalin A (ConA) or phorbol 12-myristate 13-acetate (PMA), which both induced a long-lasting respiratory burst, were used as stimuli, tyrosine phosphorylation and translocation of p125 GAP did not occur.	Tetradecanoylphorbol Acetate	30-61	SEC23 interacting protein	Homo sapiens	190-194
8925892-2	1996	When concanavalin A (ConA) or phorbol 12-myristate 13-acetate (PMA), which both induced a long-lasting respiratory burst, were used as stimuli, tyrosine phosphorylation and translocation of p125 GAP did not occur.	Tetradecanoylphorbol Acetate	63-66	SEC23 interacting protein	Homo sapiens	190-194
8657160-8	1996	Conversely, a catalytically inactive PKC-theta K409R (but not PKC-alpha K368R) mutant abrogated endogenous PMA-mediated activation of AP-1 transcriptional complex.	Tetradecanoylphorbol Acetate	107-110	protein kinase C, theta	Mus musculus	37-46
8649827-5	1996	In cultured ovarian cancer cells, c-jun and jun-B expression is inducible by serum and TPA and is therefore not constitutive.	Tetradecanoylphorbol Acetate	87-90	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-39
8626452-4	1996	Here we characterize a new MAP kinase phosphatase, MKP-2, that is induced in human peripheral blood T cells with phorbol 12-myristate 13-acetate and is expressed in a variety of nonhematopoietic tissues as well.	Tetradecanoylphorbol Acetate	113-144	dual specificity phosphatase 4	Homo sapiens	51-56
8638652-2	1996	Here, we investigated the effects of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) on these receptor subtypes in cultured astroglia to understand the intracellular processes involved in the modulation of natriuretic peptide receptors in these cells.	Tetradecanoylphorbol Acetate	74-105	protein kinase C, gamma	Rattus norvegicus	59-62
8638652-2	1996	Here, we investigated the effects of the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) on these receptor subtypes in cultured astroglia to understand the intracellular processes involved in the modulation of natriuretic peptide receptors in these cells.	Tetradecanoylphorbol Acetate	107-110	protein kinase C, gamma	Rattus norvegicus	59-62
8703583-6	1996	Northern analysis demonstrated that mRNA for IGF-I receptor was expressed by both untreated and TPA-treated FLG 29.1 cells.	Tetradecanoylphorbol Acetate	96-99	insulin like growth factor 1 receptor	Homo sapiens	45-59
8703583-7	1996	In addition, FLG 29.1 cells released in the conditioned medium IGFBP-2 and IGFBP-4, whose expression was increased by TPA treatment as demonstrated by ligand and immunoblot analyses.	Tetradecanoylphorbol Acetate	118-121	insulin like growth factor binding protein 4	Homo sapiens	75-82
8631129-10	1996	TCDD did not increase mRNA of c-fos, c-jun, junB or junD (in contrast to TPA which markedly increased the expression of c-fos and junB), nor did TCDD increase AP-1 activity.	Tetradecanoylphorbol Acetate	73-76	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-125
8671615-7	1996	We found that pretreatment of DP thymocytes with ionomycin and PMA followed by 1 day culture of the cells without the reagents resulted in the differentiation of the cells into CD4 SP and CD4+ CD8lo T cells that have mostly committed to the CD4 lineage.	Tetradecanoylphorbol Acetate	63-66	CD4 antigen	Mus musculus	177-180
8671615-7	1996	We found that pretreatment of DP thymocytes with ionomycin and PMA followed by 1 day culture of the cells without the reagents resulted in the differentiation of the cells into CD4 SP and CD4+ CD8lo T cells that have mostly committed to the CD4 lineage.	Tetradecanoylphorbol Acetate	63-66	CD4 antigen	Mus musculus	188-191
8671615-7	1996	We found that pretreatment of DP thymocytes with ionomycin and PMA followed by 1 day culture of the cells without the reagents resulted in the differentiation of the cells into CD4 SP and CD4+ CD8lo T cells that have mostly committed to the CD4 lineage.	Tetradecanoylphorbol Acetate	63-66	CD4 antigen	Mus musculus	188-191
8627667-6	1996	Chimeric ZEBRA/c-Fos proteins overexpressed in Escherichia coli bound DNA with the specificity of c-Fos; they bound a heptamer AP-1 site and an octamer TPA response element (TRE).	Tetradecanoylphorbol Acetate	152-155	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-20
8627667-6	1996	Chimeric ZEBRA/c-Fos proteins overexpressed in Escherichia coli bound DNA with the specificity of c-Fos; they bound a heptamer AP-1 site and an octamer TPA response element (TRE).	Tetradecanoylphorbol Acetate	152-155	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-103
8597533-8	1996	The peaks of Cx26 and Cx43 expression and Cx31.1 inhibition appeared 12 h after TPA application and 24 h after OA and chrysarobin application.	Tetradecanoylphorbol Acetate	80-83	gap junction protein, beta 5	Mus musculus	42-48
8700159-1	1996	A correlation of the levels of epidermal protein kinase C (PKC) isozymes, steady state levels of ornithine decarboxylase (ODC) mRNA, and ODC antizyme with the induction of ornithine decarboxylase (ODC) activity by a second repeat 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment to mouse skin was determined.	Tetradecanoylphorbol Acetate	268-271	ornithine decarboxylase, structural 1	Mus musculus	172-195
8700159-2	1996	A single application of TPA to female CD-1 mouse skin leads to a dramatic induction of ODC activity (approximately 3 nmol CO2/60 min/mg protein) which peaks at about 5 h after treatment.	Tetradecanoylphorbol Acetate	24-27	ornithine decarboxylase, structural 1	Mus musculus	87-90
8700159-3	1996	However, a superinduction of ODC activity (approximately 13 CO2/60 min/mg protein) is observed upon the second TPA application at 48 or 72 h after the first TPA treatment.	Tetradecanoylphorbol Acetate	111-114	ornithine decarboxylase, structural 1	Mus musculus	29-32
8700159-7	1996	TPA-induced steady state levels of ODC mRNA did not correlate with the degree of superinduction of ODC activity by TPA.	Tetradecanoylphorbol Acetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	35-38
8700159-8	1996	The second TPA treatment, 72 h after the first TPA treatment, which leads to superinduction of ODC activity did not decrease the levels of the ODC-antizyme.	Tetradecanoylphorbol Acetate	11-14	ornithine decarboxylase, structural 1	Mus musculus	95-98
8621683-8	1996	Neutrophil activating factors, i.e. IL-8, phorbol 12-myristate 13-acetate/ionomycin, and formylmethionylleucylphenylalanine each induced the release of CAP37 and defensins from neutrophil granules.	Tetradecanoylphorbol Acetate	42-73	azurocidin 1	Homo sapiens	152-157
8599579-4	1996	When Rat-2 fibroblasts were stably transfected with an expression vector producing PKCbeta, however, TPA treatment of these variants resulted in a 3.1-fold induction of stromelysin promoter-mediated luciferase activity compared with a 1.3-fold induction in parental Rat-2 cells (P&lt;0.002).	Tetradecanoylphorbol Acetate	101-104	protein kinase C, beta	Rattus norvegicus	83-90
8547633-2	1996	Treatment of these cells with 10 nmol/L phorbol 12-myristate 13-acetate (PMA) for 3 days caused a complete inhibition of proliferation and a threefold increase in the surface expression of glycoprotein (GP) IIIa, a marker of megakaryocytic differentiation that forms part of the fibrinogen receptor complex, GPIIb/IIIa.	Tetradecanoylphorbol Acetate	40-71	integrin subunit alpha 2b	Homo sapiens	308-313
8547633-2	1996	Treatment of these cells with 10 nmol/L phorbol 12-myristate 13-acetate (PMA) for 3 days caused a complete inhibition of proliferation and a threefold increase in the surface expression of glycoprotein (GP) IIIa, a marker of megakaryocytic differentiation that forms part of the fibrinogen receptor complex, GPIIb/IIIa.	Tetradecanoylphorbol Acetate	73-76	integrin subunit alpha 2b	Homo sapiens	308-313
8565269-5	1996	Data showed a significantly higher production of IL-4 (P = 0.05) and IL-10 (P &lt; 0.005) as determined by ELISA in phytohaemagglutinin (PHA)/phorbol myristate acetate (PMA)-stimulated mononuclear cells of atopic donors compared with controls, although spontaneous IL-4 production without stimulation was never detected within either atopic or control groups.	Tetradecanoylphorbol Acetate	142-167	interleukin 10	Homo sapiens	69-74
8993955-2	1996	OBJECT: The aim of the present study was to examine the enhancing effects of UVA on changes in mouse skin mediated by the tumor promoter 12-o-tetradecanoylphorbol-13-acetate (TPA) by measurement of ornithine decarboxylase (ODC) activity and morphometric analysis.	Tetradecanoylphorbol Acetate	137-173	ornithine decarboxylase, structural 1	Mus musculus	223-226
8993955-2	1996	OBJECT: The aim of the present study was to examine the enhancing effects of UVA on changes in mouse skin mediated by the tumor promoter 12-o-tetradecanoylphorbol-13-acetate (TPA) by measurement of ornithine decarboxylase (ODC) activity and morphometric analysis.	Tetradecanoylphorbol Acetate	175-178	ornithine decarboxylase, structural 1	Mus musculus	198-221
8993955-2	1996	OBJECT: The aim of the present study was to examine the enhancing effects of UVA on changes in mouse skin mediated by the tumor promoter 12-o-tetradecanoylphorbol-13-acetate (TPA) by measurement of ornithine decarboxylase (ODC) activity and morphometric analysis.	Tetradecanoylphorbol Acetate	175-178	ornithine decarboxylase, structural 1	Mus musculus	223-226
8993955-6	1996	RESULTS: A combination of topical TPA application and UVA irradiation produced a greater increment of ODC activity at 4 h than TPA alone (p &lt; 0.05).	Tetradecanoylphorbol Acetate	34-37	ornithine decarboxylase, structural 1	Mus musculus	102-105
8993955-8	1996	Pretreatment of mice with curcumin significantly abrogated the TPA-induced changes in ODC activity and the dermal infiltrating inflammatory cells as well as the TPA plus UVA-mediated enhancement of these changes.	Tetradecanoylphorbol Acetate	63-66	ornithine decarboxylase, structural 1	Mus musculus	86-89
8993955-9	1996	CONCLUSION: Our data indicate that UVA irradiation (18.72 J/cm2) significantly enhances ODC induction at an early stage (4-6 h) after topical application of TPA, and aggravates the dermatitis elicited by TPA.	Tetradecanoylphorbol Acetate	157-160	ornithine decarboxylase, structural 1	Mus musculus	88-91
8993955-9	1996	CONCLUSION: Our data indicate that UVA irradiation (18.72 J/cm2) significantly enhances ODC induction at an early stage (4-6 h) after topical application of TPA, and aggravates the dermatitis elicited by TPA.	Tetradecanoylphorbol Acetate	204-207	ornithine decarboxylase, structural 1	Mus musculus	88-91
8706790-4	1996	In both young and old cells, phorbol myristoyl-13 acetate (PMA) induced the expression of transcripts of collagenase, stromelysin-1, gelatinase-B, TIMP-1, and TIMP-3.	Tetradecanoylphorbol Acetate	59-62	TIMP metallopeptidase inhibitor 3	Homo sapiens	159-165
8598475-5	1996	Studies with these cells and the RC2A myeloid cell line stimulated with tetradecanoyl phorbol acetate or FMLP indicated that the 25E11 epitope on Mac-1 did not depend on cell activation for its expression.	Tetradecanoylphorbol Acetate	72-101	integrin subunit alpha M	Homo sapiens	146-151
8745276-26	1996	The addition of phorbol myristate acetate, an activator of protein kinase C, consistently produced a reduction in the amplitudeof INa without affecting the time course of activation or inactivation.	Tetradecanoylphorbol Acetate	16-41	internexin neuronal intermediate filament protein, alpha	Mus musculus	130-133
8632699-6	1996	We observed that PMA (0.1 microM) stimulated ANP release whereas H-7 (10 microM), an inhibitor of PKC in the presence of Ang II, prevented ANP increase.	Tetradecanoylphorbol Acetate	17-20	natriuretic peptide A	Rattus norvegicus	45-48
21594347-4	1996	TPA treated PKC-zeta cells undergo apoptosis without differentiating.	Tetradecanoylphorbol Acetate	0-3	protein kinase C zeta	Homo sapiens	12-20
21594347-5	1996	TPA treated PKC-zeta cells express Cip1 and display substantial hypophosphorylation of Rb but fail to arrest in G(1).	Tetradecanoylphorbol Acetate	0-3	protein kinase C zeta	Homo sapiens	12-20
8871296-3	1995	On the other hand, when the cells were stimulated by phorbol 12-myristate 13-acetate (PMA) or ionophore (A23187), PKCalpha and beta were predominantly translocated.	Tetradecanoylphorbol Acetate	53-84	protein kinase C, alpha	Rattus norvegicus	114-131
8871296-3	1995	On the other hand, when the cells were stimulated by phorbol 12-myristate 13-acetate (PMA) or ionophore (A23187), PKCalpha and beta were predominantly translocated.	Tetradecanoylphorbol Acetate	86-89	protein kinase C, alpha	Rattus norvegicus	114-131
8845939-8	1995	Similarly, the protein kinase C inhibitor 1-(5-isoquinoline-sulphonyl)-2-methylpiperazine dihydrochloride (H7) and down-regulation of protein kinase C by prolonged exposure to phorbol-12-myristate 13-acetate blocked c-fos induction.	Tetradecanoylphorbol Acetate	176-207	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	216-221
7490476-10	1995	Northern blot analysis revealed that c-jun mRNA was induced by IFN-gamma plus anti-Fas antibody treatment as well as by TPA treatment; the addition of IFN-gamma alone to the incubation medium had no effect on the expression of c-jun mRNA.	Tetradecanoylphorbol Acetate	120-123	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-42
7499234-3	1995	A potent inducer of PDGF-A expression in endothelial cells is phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	62-93	platelet derived growth factor subunit A	Homo sapiens	20-26
7499234-3	1995	A potent inducer of PDGF-A expression in endothelial cells is phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	95-98	platelet derived growth factor subunit A	Homo sapiens	20-26
7594491-10	1995	Moreover, NIF prevented PMA-induced neutrophil adhesion to fibrinogen, a CD11b/CD18-dependent event, but produced a smaller decrease in adherence to endothelial cells, which also involves CD11a/CD18 integrins.	Tetradecanoylphorbol Acetate	24-27	integrin subunit alpha M	Homo sapiens	73-78
7586808-1	1995	We previously found that 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced invasion of Matrigel was associated with augmentation of cell motility but not with metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1.	Tetradecanoylphorbol Acetate	25-61	troponin I3, cardiac type	Homo sapiens	267-272
7586808-1	1995	We previously found that 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced invasion of Matrigel was associated with augmentation of cell motility but not with metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1.	Tetradecanoylphorbol Acetate	63-66	troponin I3, cardiac type	Homo sapiens	267-272
7588236-9	1995	When cultured granulosa cells were exposed to 100 nM ET-1 or 14 nM 12-O-tetradecanoylphorbol 13-acetate overnight, the percentage of specific [125I]ET-1 binding was reduced (12% and 50%, respectively), indicating a down-regulation of the ET receptor by these treatments.	Tetradecanoylphorbol Acetate	67-103	endothelin-1	Sus scrofa	148-152
7591091-3	1995	To investigate the mechanisms accounting for the impaired responses to gamma interferon, a model system for examining overall changes in protein tyrosine phosphorylation, activation of Jak1 and Jak2 and phosphorylation of Stat1 was developed in phorbol 12-myristate 13-acetate-differentiated U-937 cells.	Tetradecanoylphorbol Acetate	245-276	signal transducer and activator of transcription 1	Homo sapiens	222-227
8550072-5	1995	With adult purified T cells, high levels of IL-10 and IL-4 were measured following CD3 plus CD28 stimulation, and the amounts of both T-helper type-2 (Th2) cytokines decreased following the addition of phorbol myristate acetate (PMA), whereas the synthesis of the Th1 cytokines IL-2 and IFN-gamma was enhanced.	Tetradecanoylphorbol Acetate	202-227	interleukin 10	Homo sapiens	44-49
8550072-5	1995	With adult purified T cells, high levels of IL-10 and IL-4 were measured following CD3 plus CD28 stimulation, and the amounts of both T-helper type-2 (Th2) cytokines decreased following the addition of phorbol myristate acetate (PMA), whereas the synthesis of the Th1 cytokines IL-2 and IFN-gamma was enhanced.	Tetradecanoylphorbol Acetate	202-227	negative elongation factor complex member C/D	Homo sapiens	264-267
8583698-5	1995	PAF stimulated 3H-thymidine incorporation at concentrations below 10(-6) M, but exerted progressive inhibition at concentrations above 10(-6) M. Pre-treatment with phorbol 12-myristate 13-acetate (PMA) did not affect PAF-enhanced incorporation at lower concentrations of PAF, and reversed the inhibitory effects of PAF at higher concentrations.	Tetradecanoylphorbol Acetate	197-200	PCNA clamp associated factor	Rattus norvegicus	0-3
7592779-1	1995	Stimulation of NIH 3T3 cells with platelet-derived growth factor (PDGF)-BB and 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances vascular endothelial growth factor (VEGF) gene expression.	Tetradecanoylphorbol Acetate	79-115	vascular endothelial growth factor A	Mus musculus	131-165
7592779-1	1995	Stimulation of NIH 3T3 cells with platelet-derived growth factor (PDGF)-BB and 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances vascular endothelial growth factor (VEGF) gene expression.	Tetradecanoylphorbol Acetate	79-115	vascular endothelial growth factor A	Mus musculus	167-171
7592779-1	1995	Stimulation of NIH 3T3 cells with platelet-derived growth factor (PDGF)-BB and 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances vascular endothelial growth factor (VEGF) gene expression.	Tetradecanoylphorbol Acetate	117-120	vascular endothelial growth factor A	Mus musculus	131-165
7488237-0	1995	Preferential requirement for protein tyrosine phosphatase activity in the 12-O-tetradecanoylphorbol-13-acetate-induced differentiation of human colon cancer cells.	Tetradecanoylphorbol Acetate	74-110	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	29-57
7488237-2	1995	The increases in activities of both protein tyrosine phosphatase (PTP) and protein tyrosine kinase (PTK) have been reported to be associated with the TPA-induced differentiation of HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	150-153	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	36-64
7488237-2	1995	The increases in activities of both protein tyrosine phosphatase (PTP) and protein tyrosine kinase (PTK) have been reported to be associated with the TPA-induced differentiation of HL-60 leukemia cells.	Tetradecanoylphorbol Acetate	150-153	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	66-69
7488237-3	1995	In the present study, a 2-fold increase in PTP activity was observed in SW620 human colon cancer cells after 30 min of TPA treatment; a maximal level (4- to 5-fold) was reached at 60 min and continued for more than 6 hr.	Tetradecanoylphorbol Acetate	119-122	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	43-46
7488237-4	1995	In addition, two TPA-induced differentiated characteristics, morphological alteration and release of cellular surface proteoglycan, were effectively blocked by PTP inhibitors, such as sodium orthovanadate (50 microM), zinc chloride (100 microM), and iodoacetate (250 microM), but not by the protein serine/threonine phosphatase inhibitor okadaic acid (20 nM).	Tetradecanoylphorbol Acetate	17-20	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	160-163
7488237-7	1995	Taken together, these observations suggest that both PTP and PTK activities were increased in SW620 cells in response to TPA; however, the activation of PTP seems to be preferentially required for the TPA-induced differentiation of SW620 human colon cancer cells.	Tetradecanoylphorbol Acetate	121-124	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	53-56
7488237-7	1995	Taken together, these observations suggest that both PTP and PTK activities were increased in SW620 cells in response to TPA; however, the activation of PTP seems to be preferentially required for the TPA-induced differentiation of SW620 human colon cancer cells.	Tetradecanoylphorbol Acetate	201-204	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	153-156
8578682-7	1995	Dot blot analysis indicated that the expression of IL-1 beta was predominant to that of IL-1 alpha in equine PBMC stimulated with LPS or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	137-162	interleukin 1 alpha	Equus caballus	88-98
7595139-8	1995	In the presence of staurosporine, an inhibitor of protein kinase C (PKC), the magnitude of the increase in tyrosinase due to PMA, ACTH and di-MSH was significantly reduced.	Tetradecanoylphorbol Acetate	125-128	tyrosinase	Homo sapiens	107-117
7544583-5	1995	If stimulated with PMA plus ionomycin, JCaM expressed Fas-L mRNA and underwent apoptosis.	Tetradecanoylphorbol Acetate	19-22	F11 receptor	Homo sapiens	39-43
7646440-3	1995	PMA increased particulate phospholipase A2 (PLA2) activity, lysophosphatidylcholine formation and arachidonic acid release from bone marrow cells; these effects were abolished when cells were pretreated with the putative PLA2 inhibitors heparin and mepacrine.	Tetradecanoylphorbol Acetate	0-3	phospholipase A2, group IB, pancreas	Mus musculus	26-42
7646440-3	1995	PMA increased particulate phospholipase A2 (PLA2) activity, lysophosphatidylcholine formation and arachidonic acid release from bone marrow cells; these effects were abolished when cells were pretreated with the putative PLA2 inhibitors heparin and mepacrine.	Tetradecanoylphorbol Acetate	0-3	phospholipase A2, group IB, pancreas	Mus musculus	44-48
7646440-3	1995	PMA increased particulate phospholipase A2 (PLA2) activity, lysophosphatidylcholine formation and arachidonic acid release from bone marrow cells; these effects were abolished when cells were pretreated with the putative PLA2 inhibitors heparin and mepacrine.	Tetradecanoylphorbol Acetate	0-3	phospholipase A2, group IB, pancreas	Mus musculus	221-225
7646440-6	1995	Pretreatment of cells with PLA2 inhibitors reduced the amount of membrane-bound PKC-zeta in unstimulated cells and diminished PMA-induced translocation of PKC-zeta to membranes without affecting other PKC isoforms.	Tetradecanoylphorbol Acetate	126-129	phospholipase A2, group IB, pancreas	Mus musculus	27-31
7646440-10	1995	The effects of PMA, but not those of arachidonic acid, could be prevented by putative PLA2 inhibitors.	Tetradecanoylphorbol Acetate	15-18	phospholipase A2, group IB, pancreas	Mus musculus	86-90
7646440-11	1995	This suggests that PMA-mediated activation of conventional PKCs and novel PKCs leads to PLA2 activation which, by releasing arachidonic acid from phospholipids, activates PKC-zeta.	Tetradecanoylphorbol Acetate	19-22	phospholipase A2, group IB, pancreas	Mus musculus	88-92
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Tetradecanoylphorbol Acetate	132-163	C-X-C motif chemokine ligand 1	Homo sapiens	93-102
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Tetradecanoylphorbol Acetate	132-163	C-X-C motif chemokine ligand 1	Homo sapiens	103-107
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Tetradecanoylphorbol Acetate	165-168	C-X-C motif chemokine ligand 1	Homo sapiens	93-102
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Tetradecanoylphorbol Acetate	165-168	C-X-C motif chemokine ligand 1	Homo sapiens	103-107
7631746-6	1995	Functionally, human NHE3 was similar to the rabbit and rat NHE3 homologues, being relatively resistant to inhibition by amiloride, half-maximal inhibition (IC50) = 49.0 microM, and ethylisopropylamiloride, IC50 = 6.6 microM, and being stimulated by fibroblast growth factor but inhibited by phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	291-322	solute carrier family 9 member A3	Homo sapiens	20-24
7628546-2	1995	All PKC isoenzymes except PKC zeta are down-regulated by TPA as well as by bryostatin.	Tetradecanoylphorbol Acetate	57-60	protein kinase C zeta	Homo sapiens	26-34
7589783-6	1995	Under identical conditions, TPA and serum rapidly induce c-fos transcription in RENE1 cells, indicating that the lack of inducibility by estradiol is not due to a general inhibitor of transcription of these genes.	Tetradecanoylphorbol Acetate	28-31	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-62
7775415-2	1995	The long terminal repeat (LTR) of Mo-MuLV affects the regulation of a number of cellular genes, including collagenase IV, monocyte chemoattractant protein-1, and c-jun genes, all of which contain 12-O-tetradecanoylphorbol-13-acetate-responsive element consensus sites within their promoters.	Tetradecanoylphorbol Acetate	196-232	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	162-167
7670565-2	1995	The protective effect of anti-CD11a and anti-intercellular adhesion molecule (ICAM-1) antibodies on the cytotoxity elicited by phorbol 12-myristate 13-acetate (PMA)-stimulated lymphocytes was investigated by using cultured bovine glomerular endothelial cells (GEN).	Tetradecanoylphorbol Acetate	127-158	intercellular adhesion molecule 1	Bos taurus	78-84
7670565-2	1995	The protective effect of anti-CD11a and anti-intercellular adhesion molecule (ICAM-1) antibodies on the cytotoxity elicited by phorbol 12-myristate 13-acetate (PMA)-stimulated lymphocytes was investigated by using cultured bovine glomerular endothelial cells (GEN).	Tetradecanoylphorbol Acetate	160-163	intercellular adhesion molecule 1	Bos taurus	78-84
7769268-5	1995	Exposure to PMA induced ICAM-1 both at the mRNA and cell surface level.	Tetradecanoylphorbol Acetate	12-15	intercellular adhesion molecule 1	Homo sapiens	24-30
7761434-9	1995	We therefore conclude that inhibitory AP-1 complexes composed of Jun-Fra heterodimers, induced by BHQ, antagonize the transcriptional effects of the tumor promoter TPA, which are mediated by Jun-Fos heterodimers.	Tetradecanoylphorbol Acetate	164-167	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	195-198
7766652-9	1995	Furthermore, treatment of infected Sf9 cells expressing the wild-type cPLA2 with phorbol 12-tetradecanoate 13-acetate (TPA) shifted all of the overexpressed cPLA2 to the phosphorylated Ser-505 form.	Tetradecanoylphorbol Acetate	81-117	phospholipase A2 group IVA	Homo sapiens	70-75
7766652-9	1995	Furthermore, treatment of infected Sf9 cells expressing the wild-type cPLA2 with phorbol 12-tetradecanoate 13-acetate (TPA) shifted all of the overexpressed cPLA2 to the phosphorylated Ser-505 form.	Tetradecanoylphorbol Acetate	81-117	phospholipase A2 group IVA	Homo sapiens	157-162
7766652-9	1995	Furthermore, treatment of infected Sf9 cells expressing the wild-type cPLA2 with phorbol 12-tetradecanoate 13-acetate (TPA) shifted all of the overexpressed cPLA2 to the phosphorylated Ser-505 form.	Tetradecanoylphorbol Acetate	119-122	phospholipase A2 group IVA	Homo sapiens	70-75
7766652-9	1995	Furthermore, treatment of infected Sf9 cells expressing the wild-type cPLA2 with phorbol 12-tetradecanoate 13-acetate (TPA) shifted all of the overexpressed cPLA2 to the phosphorylated Ser-505 form.	Tetradecanoylphorbol Acetate	119-122	phospholipase A2 group IVA	Homo sapiens	157-162
7737978-4	1995	Inhibition of PKC, by treatment with staurosporin (50 nM for 2 h), or down-regulation of PKC, by prolonged treatment with TPA (400 nM for 40 h) suppresses the TPA-enhanced receptor phosphorylation, but has no effect on the MGSA-enhanced receptor phosphorylation.	Tetradecanoylphorbol Acetate	122-125	C-X-C motif chemokine ligand 1	Homo sapiens	223-227
7737978-4	1995	Inhibition of PKC, by treatment with staurosporin (50 nM for 2 h), or down-regulation of PKC, by prolonged treatment with TPA (400 nM for 40 h) suppresses the TPA-enhanced receptor phosphorylation, but has no effect on the MGSA-enhanced receptor phosphorylation.	Tetradecanoylphorbol Acetate	159-162	C-X-C motif chemokine ligand 1	Homo sapiens	223-227
7737978-6	1995	TPA treatment also results in a time-dependent decrease in 125I-MGSA binding to the 3ASubE P-3 cells.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 1	Homo sapiens	64-68
7737978-7	1995	A 30-min treatment with 400 nM TPA results in approximately a 50% decrease in binding, whereas a 2-h treatment essentially eliminates specific binding of 125I-MGSA to these cells.	Tetradecanoylphorbol Acetate	31-34	C-X-C motif chemokine ligand 1	Homo sapiens	159-163
7737978-8	1995	The TPA-induced decrease in 125I-MGSA binding is accompanied by enhanced degradation of the IL-8RB, as indicated by Western blot analysis and pulse-chase experiments, suggesting a potential role for PKC as a negative regulator of the IL-8RB.	Tetradecanoylphorbol Acetate	4-7	C-X-C motif chemokine ligand 1	Homo sapiens	33-37
7713939-8	1995	While PKC-delta WT overexpressed in 32D cells demonstrated 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent translocation from the cytosolic to the membrane fraction, PKC-delta K376R was exclusively localized in the membrane fraction even prior to TPA stimulation.	Tetradecanoylphorbol Acetate	59-95	protein kinase C, delta	Mus musculus	6-15
7713939-8	1995	While PKC-delta WT overexpressed in 32D cells demonstrated 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent translocation from the cytosolic to the membrane fraction, PKC-delta K376R was exclusively localized in the membrane fraction even prior to TPA stimulation.	Tetradecanoylphorbol Acetate	97-100	protein kinase C, delta	Mus musculus	6-15
7713939-8	1995	While PKC-delta WT overexpressed in 32D cells demonstrated 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent translocation from the cytosolic to the membrane fraction, PKC-delta K376R was exclusively localized in the membrane fraction even prior to TPA stimulation.	Tetradecanoylphorbol Acetate	97-100	protein kinase C, delta	Mus musculus	171-180
7713939-8	1995	While PKC-delta WT overexpressed in 32D cells demonstrated 12-O-tetradecanoylphorbol-13-acetate (TPA)-dependent translocation from the cytosolic to the membrane fraction, PKC-delta K376R was exclusively localized in the membrane fraction even prior to TPA stimulation.	Tetradecanoylphorbol Acetate	252-255	protein kinase C, delta	Mus musculus	6-15
7713939-10	1995	Although exposure of PKC-delta WT transfectants to TPA induced 32D monocytic differentiation, the 32D/PKC-delta K376R transfectants were resistant to TPA-induced differentiation.	Tetradecanoylphorbol Acetate	51-54	protein kinase C, delta	Mus musculus	21-30
7713939-11	1995	Thus, expression of active PKC-delta is required to mediate 32D monocytic differentiation in response to TPA stimulation.	Tetradecanoylphorbol Acetate	105-108	protein kinase C, delta	Mus musculus	27-36
7713942-2	1995	The effect is mimicked by phorbol esters, which directly activate protein kinase C. Using human embryonic kidney cells expressing individual muscarinic receptor subtypes, we found that stimulation of APPs release by the muscarinic agonist carbachol was only partially reduced by a specific inhibitor of protein kinase C (the bisindolylmaleimide GF 109203X), while the response to phorbol 12-myristate 13-acetate (PMA) was abolished.	Tetradecanoylphorbol Acetate	380-411	cathepsin B	Homo sapiens	200-204
7713942-2	1995	The effect is mimicked by phorbol esters, which directly activate protein kinase C. Using human embryonic kidney cells expressing individual muscarinic receptor subtypes, we found that stimulation of APPs release by the muscarinic agonist carbachol was only partially reduced by a specific inhibitor of protein kinase C (the bisindolylmaleimide GF 109203X), while the response to phorbol 12-myristate 13-acetate (PMA) was abolished.	Tetradecanoylphorbol Acetate	413-416	cathepsin B	Homo sapiens	200-204
7713942-3	1995	The increase in APPs release elicited by carbachol and PMA was accompanied by elevated tyrosine phosphorylation of several proteins and reduced by tyrosine kinase inhibitors; GF 109203X significantly reduced the stimulation of tyrosine phosphorylation by carbachol and PMA.	Tetradecanoylphorbol Acetate	55-58	cathepsin B	Homo sapiens	16-20
7713942-3	1995	The increase in APPs release elicited by carbachol and PMA was accompanied by elevated tyrosine phosphorylation of several proteins and reduced by tyrosine kinase inhibitors; GF 109203X significantly reduced the stimulation of tyrosine phosphorylation by carbachol and PMA.	Tetradecanoylphorbol Acetate	269-272	cathepsin B	Homo sapiens	16-20
7718627-8	1995	Moreover, while both TPA and bFGF stimulated the hyperphosphorylation of c-RAF and the activity of MAP kinase, TPA pretreatment failed to block RAF phosphorylation or the stimulation of MAP kinase activity by bFGF.	Tetradecanoylphorbol Acetate	21-24	v-raf-leukemia viral oncogene 1	Mus musculus	73-78
7717978-5	1995	The tumour promoter and protein kinase C agonist, phorbol 12-myristate 13-acetate (PMA), also activated Raf-1, MEK-1, and MAP kinase in Ramos cells, but did not induce tyrosine phosphorylation of Shc or Shc/Grb2 association.	Tetradecanoylphorbol Acetate	83-86	SHC adaptor protein 1	Homo sapiens	196-199
7717978-5	1995	The tumour promoter and protein kinase C agonist, phorbol 12-myristate 13-acetate (PMA), also activated Raf-1, MEK-1, and MAP kinase in Ramos cells, but did not induce tyrosine phosphorylation of Shc or Shc/Grb2 association.	Tetradecanoylphorbol Acetate	83-86	SHC adaptor protein 1	Homo sapiens	203-206
7698224-7	1995	TPA also induced translocation of both the desmoyokin/AHNAK protein and desmoplakin, which was completely inhibited by PKC inhibitors.	Tetradecanoylphorbol Acetate	0-3	AHNAK nucleoprotein	Homo sapiens	43-53
7698224-7	1995	TPA also induced translocation of both the desmoyokin/AHNAK protein and desmoplakin, which was completely inhibited by PKC inhibitors.	Tetradecanoylphorbol Acetate	0-3	AHNAK nucleoprotein	Homo sapiens	54-59
7896891-5	1995	However, vimentin expression was markedly delayed in okadaic acid-treated relative to TPA-treated cells.	Tetradecanoylphorbol Acetate	86-89	vimentin	Mus musculus	9-17
7659084-4	1995	We found that a functional NF-kappa B site in the ICAM-1 promoter, which can be activated by either 12-O-tetradecanoylphorbol-13-acetate or tumor necrosis factor-alpha (TNF alpha), is also the target for glucocorticoids.	Tetradecanoylphorbol Acetate	100-136	intercellular adhesion molecule 1	Homo sapiens	50-56
7534287-4	1995	Comparison of phosphopeptide maps of Raf-1 immunoprecipitated from the two cell types activated by either aFGF or the phorbol ester (12-O-tetradecanoylphorbol-13-acetate) suggests that Raf-1 is phosphorylated by both Ras-dependent and PLC-gamma-dependent mechanisms.	Tetradecanoylphorbol Acetate	133-169	v-raf-leukemia viral oncogene 1	Mus musculus	37-42
7534287-4	1995	Comparison of phosphopeptide maps of Raf-1 immunoprecipitated from the two cell types activated by either aFGF or the phorbol ester (12-O-tetradecanoylphorbol-13-acetate) suggests that Raf-1 is phosphorylated by both Ras-dependent and PLC-gamma-dependent mechanisms.	Tetradecanoylphorbol Acetate	133-169	v-raf-leukemia viral oncogene 1	Mus musculus	185-190
7890673-4	1995	We have recently demonstrated that induction of PDGF-A chain mRNA abundance in response to phorbol 12-myristate 13-acetate is primarily due to gene transcription.	Tetradecanoylphorbol Acetate	91-122	platelet derived growth factor subunit A	Homo sapiens	48-54
7763014-4	1995	Topical application of geniposide inhibited tumor promoter-caused induction of epidermal ODC activity by TPA (5 nmol).	Tetradecanoylphorbol Acetate	105-108	ornithine decarboxylase, structural 1	Mus musculus	89-92
7763014-6	1995	Pretreatment of mouse skin with various amounts of geniposide caused inhibition of hydrogen peroxide (H2O2) and myeloperoxidase (MPO) formation by TPA.	Tetradecanoylphorbol Acetate	147-150	myeloperoxidase	Mus musculus	112-127
7763014-6	1995	Pretreatment of mouse skin with various amounts of geniposide caused inhibition of hydrogen peroxide (H2O2) and myeloperoxidase (MPO) formation by TPA.	Tetradecanoylphorbol Acetate	147-150	myeloperoxidase	Mus musculus	129-132
7867590-5	1995	Secondly, in prolonged (4-day) treatments of MTLN (ER-positive) cells, low antiestrogen concentrations (nanomolar) decreased the basal AP-1 response by about 2 and increased the 12-O-tetradecanoyl-phorbol-13-acetate-stimulated AP-1 response by about 3-4.	Tetradecanoylphorbol Acetate	178-215	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	227-231
7862129-5	1995	We show that in HepG2 cells the AP-1 sequence confers 12-O-tetradecanoylphorbol-13-acetate inducibility to the TTR promoter and contributes to normal TTR transcriptional activity.	Tetradecanoylphorbol Acetate	54-90	transthyretin	Homo sapiens	111-114
7862129-7	1995	In addition, 12-O-tetradecanoylphorbol-13-acetate exposure of HepG2 cells results in a reciprocal decrease in HNF-3 alpha and -3 gamma expression which may facilitate interaction of AP-1 with the TTR AP-1-HNF-3 site.	Tetradecanoylphorbol Acetate	13-49	transthyretin	Homo sapiens	196-199
7862129-7	1995	In addition, 12-O-tetradecanoylphorbol-13-acetate exposure of HepG2 cells results in a reciprocal decrease in HNF-3 alpha and -3 gamma expression which may facilitate interaction of AP-1 with the TTR AP-1-HNF-3 site.	Tetradecanoylphorbol Acetate	13-49	forkhead box M1	Homo sapiens	110-115
7822428-6	1995	Moreover, in vitamin D-sufficient rats, treatment of colonocytes with 1,25(OH)2D3 or 12-O-tetradecanoyl phorbol 13-acetate (TPA), a known activator of PKC, significantly increased the phosphorylation of pp42 and pp48 in broken cell preparations.	Tetradecanoylphorbol Acetate	85-122	eukaryotic translation initiation factor 2 subunit gamma	Rattus norvegicus	203-207
7822428-6	1995	Moreover, in vitamin D-sufficient rats, treatment of colonocytes with 1,25(OH)2D3 or 12-O-tetradecanoyl phorbol 13-acetate (TPA), a known activator of PKC, significantly increased the phosphorylation of pp42 and pp48 in broken cell preparations.	Tetradecanoylphorbol Acetate	124-127	eukaryotic translation initiation factor 2 subunit gamma	Rattus norvegicus	203-207
7707048-4	1995	Serum deprivation or chronic treatment with a protein kinase C activator 4-beta-phorbol 12-myristate 13-acetate (PMA), but not dibutyl cyclic adenosine monophosphate induced coordinate up-regulation or de novo induction of oligodendrocyte phenotypic markers with concomitant down-regulation of GFAP expression.	Tetradecanoylphorbol Acetate	73-111	glial fibrillary acidic protein	Homo sapiens	294-298
7707048-4	1995	Serum deprivation or chronic treatment with a protein kinase C activator 4-beta-phorbol 12-myristate 13-acetate (PMA), but not dibutyl cyclic adenosine monophosphate induced coordinate up-regulation or de novo induction of oligodendrocyte phenotypic markers with concomitant down-regulation of GFAP expression.	Tetradecanoylphorbol Acetate	113-116	glial fibrillary acidic protein	Homo sapiens	294-298
7531948-5	1995	Butanol and PTX also significantly reduced the upregulation of CD11b/CD18 by f-methionyl-leucyl-phenylalanine (fMLP) and platelet-activating factor (PAF) but not by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	192-195	integrin subunit alpha M	Homo sapiens	63-68
8673625-13	1995	Further investigations in HAM led us to examine the UEFA capacity at modulating the translocation of PKC, on the one hand, and the endogenous phosphorylation and membrane translocation of p47phox, on the other, in the presence of PMA or DAG.	Tetradecanoylphorbol Acetate	230-233	neutrophil cytosolic factor 1	Homo sapiens	188-195
7774103-4	1995	By contrast, PMA-induced production of IL-1 beta was impaired in RA patients and was preceded by the disregulated expression of c-Fos and c-Jun proteins when compared with healthy donors.	Tetradecanoylphorbol Acetate	13-16	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	128-133
7774103-4	1995	By contrast, PMA-induced production of IL-1 beta was impaired in RA patients and was preceded by the disregulated expression of c-Fos and c-Jun proteins when compared with healthy donors.	Tetradecanoylphorbol Acetate	13-16	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-143
7475908-5	1995	During the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced differentiation process, the contents of Gi2 alpha and Gi3 alpha increased, whereas the protein levels of Gz alpha, Gs alpha, G11 alpha and G12 alpha were observed to hardly change.	Tetradecanoylphorbol Acetate	11-48	G protein subunit alpha z	Homo sapiens	169-177
7475908-5	1995	During the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced differentiation process, the contents of Gi2 alpha and Gi3 alpha increased, whereas the protein levels of Gz alpha, Gs alpha, G11 alpha and G12 alpha were observed to hardly change.	Tetradecanoylphorbol Acetate	50-53	G protein subunit alpha z	Homo sapiens	169-177
8584456-4	1995	In the second experiment, a single application of 10 nmol of TPA to mouse skin led to a marked increase in the transcripts" level of ornithine decarboxylase (ODC) gene, protein kinase C (PKC) gene, and c-myc oncogene at four hours after TPA administration.	Tetradecanoylphorbol Acetate	61-64	ornithine decarboxylase, structural 1	Mus musculus	133-156
8584456-4	1995	In the second experiment, a single application of 10 nmol of TPA to mouse skin led to a marked increase in the transcripts" level of ornithine decarboxylase (ODC) gene, protein kinase C (PKC) gene, and c-myc oncogene at four hours after TPA administration.	Tetradecanoylphorbol Acetate	61-64	ornithine decarboxylase, structural 1	Mus musculus	158-161
8527864-6	1995	On the contrary, Rat1 cells treated with the protein kinase C agonist 12-O-tetradecanoylphorbol-13-acetate showed neither increased mdr1 mRNA expression nor stimulation of Pgp function.	Tetradecanoylphorbol Acetate	70-106	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	132-136
8001259-7	1994	Pre-exposure of mouse skin to the anti-inflammatory agent fluocinolone acetonide, antioxidants and enzyme (phospholipase A2 and lipoxygenase) inhibitors lowered the peroxidation response to subsequent exposure to TPA.	Tetradecanoylphorbol Acetate	213-216	phospholipase A2, group IB, pancreas	Mus musculus	107-140
7805728-6	1994	The expression of CD3-TCR complexes including zeta-p14 increases following activation with phorbol 12-myristate 13-acetate or concanavalin A, suggesting that proteolysis of zeta may contribute to receptor modulation or desensitization.	Tetradecanoylphorbol Acetate	91-122	ribonuclease P/MRP subunit p14	Homo sapiens	51-54
7988435-4	1994	The protein kinase C activating phorbol ester phorbol myristate acetate (TPA) stimulated TIMP-1 but not TIMP-2 activity and messenger RNA levels.	Tetradecanoylphorbol Acetate	73-76	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	89-95
7988435-8	1994	FSH, 8-bromo-cAMP, and TPA stimuli induced DNA binding complexes capable of binding to a TIMP-1 AP-1 site consensus sequence oligonucleotide.	Tetradecanoylphorbol Acetate	23-26	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	89-95
7988435-13	1994	a convergence of TPA, FSH, and cAMP mediated signals in prepubertal Sertoli cells may occur with the induction of specific AP-1 site binding complex(es) containing jun and fos proteins.	Tetradecanoylphorbol Acetate	17-20	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	172-175
7861122-4	1994	The inhibition of PKC by sphingosine or by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) at high concentration greatly reduced the mean axonal length of spinal neurons cultured in medium conditioned by cerebellar astroglia (SCn-CBg), while activation of PKC by TPA at low concentration, or by retinoic acid, was not additive to the glial effect.	Tetradecanoylphorbol Acetate	99-102	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	243-246
7526152-9	1994	Consistently, downregulation of PKC by chronic phorbol myristate acetate treatment or inhibition of PKC by H7 and staurosporine blocked PDGF- and phorbol myristate acetate- but not EGF-induced signaling and DNA synthesis.	Tetradecanoylphorbol Acetate	47-72	protein kinase C, delta	Mus musculus	32-35
7526152-9	1994	Consistently, downregulation of PKC by chronic phorbol myristate acetate treatment or inhibition of PKC by H7 and staurosporine blocked PDGF- and phorbol myristate acetate- but not EGF-induced signaling and DNA synthesis.	Tetradecanoylphorbol Acetate	146-171	protein kinase C, delta	Mus musculus	32-35
7526152-9	1994	Consistently, downregulation of PKC by chronic phorbol myristate acetate treatment or inhibition of PKC by H7 and staurosporine blocked PDGF- and phorbol myristate acetate- but not EGF-induced signaling and DNA synthesis.	Tetradecanoylphorbol Acetate	146-171	protein kinase C, delta	Mus musculus	100-103
7999086-4	1994	These factors are well known to be induced or activated by the reagents (tumor necrosis factor alpha, interleukin-1, epidermal growth factor, and phorbol myristate acetate) reported as the inducers of a cPLA2 gene.	Tetradecanoylphorbol Acetate	146-171	phospholipase A2 group IVA	Homo sapiens	203-208
7999107-2	1994	The K252a-induced polyploidization was inhibited by phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, suggesting that the polyploidization is caused through inhibition of PKC.	Tetradecanoylphorbol Acetate	52-83	mitogen-activated protein kinase kinase kinase 14	Mus musculus	93-107
7999107-2	1994	The K252a-induced polyploidization was inhibited by phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, suggesting that the polyploidization is caused through inhibition of PKC.	Tetradecanoylphorbol Acetate	85-88	mitogen-activated protein kinase kinase kinase 14	Mus musculus	93-107
7877595-1	1994	We have investigated the effect of phorbol 12-myristate 13-acetate (PMA) on platelet-derived growth factor (PDGF) B-chain gene transcription as well as on mRNA stability in cultured human mesangial cells.	Tetradecanoylphorbol Acetate	68-71	platelet derived growth factor subunit B	Homo sapiens	108-112
7872665-5	1994	tPA immunoreactivity was intermediate in Caco-2 and LOX and weak in HT-29 and fibroblasts.	Tetradecanoylphorbol Acetate	0-3	lysyl oxidase	Homo sapiens	52-55
7872665-10	1994	LOX released tPA (median 9 ng/million cells at 72 hours), PAI-1 (1050 ng/million cells) and PAI-2 (245 ng/million cells), and fibroblasts released uPA (1 ng/million cells) and PAI-1 (910 ng/million cells).	Tetradecanoylphorbol Acetate	13-16	lysyl oxidase	Homo sapiens	0-3
7525610-0	1994	High resolution analysis of cell cycle-correlated vimentin expression in asynchronously grown, TPA-treated MPC-11 cells by the novel flow cytometric multiparameter BrdU-Hoechst/PI and immunolabeling technique.	Tetradecanoylphorbol Acetate	95-98	vimentin	Mus musculus	50-58
7962120-5	1994	Phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), induced an intense expression of the c-fos gene, while 4 alpha-phorbol 12,13-didecanoate (4 alpha PDD), incapable of activating PKC, and calcium ionophores (A23187 and ionomycin) did not.	Tetradecanoylphorbol Acetate	0-31	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-121
7962120-5	1994	Phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), induced an intense expression of the c-fos gene, while 4 alpha-phorbol 12,13-didecanoate (4 alpha PDD), incapable of activating PKC, and calcium ionophores (A23187 and ionomycin) did not.	Tetradecanoylphorbol Acetate	33-36	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-121
7963658-1	1994	The induction of ornithine decarboxylase levels by the phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate (TPA) in mouse skin has been shown to be integral to tumor promotion by TPA, and changes in ornithine decarboxylase activity indicate the proliferative state of many different cell types.	Tetradecanoylphorbol Acetate	108-111	ornithine decarboxylase, structural 1	Mus musculus	17-40
7963658-1	1994	The induction of ornithine decarboxylase levels by the phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate (TPA) in mouse skin has been shown to be integral to tumor promotion by TPA, and changes in ornithine decarboxylase activity indicate the proliferative state of many different cell types.	Tetradecanoylphorbol Acetate	108-111	ornithine decarboxylase, structural 1	Mus musculus	199-222
7963658-1	1994	The induction of ornithine decarboxylase levels by the phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate (TPA) in mouse skin has been shown to be integral to tumor promotion by TPA, and changes in ornithine decarboxylase activity indicate the proliferative state of many different cell types.	Tetradecanoylphorbol Acetate	179-182	ornithine decarboxylase, structural 1	Mus musculus	17-40
7969070-2	1994	We report here that in primary mouse keratinocytes PMA caused translocation of PKC-epsilon to the Triton X-100-soluble fraction with an approximately 2-order of magnitude higher potency, compared with translocation of PKC-alpha and PKC-delta.	Tetradecanoylphorbol Acetate	51-54	protein kinase C, delta	Mus musculus	232-241
7523196-5	1994	Immunoprecipitation of PTP1B, an intracytoplasmic tyrosine phosphatase, with subsequent assay of the immunobeads for PTPase shows a significant inhibition of its activity in PMA-treated cells.	Tetradecanoylphorbol Acetate	174-177	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	23-28
7523496-5	1994	Cross-linking of CD7 or CD16 molecules with primary and secondary Abs, as well as stimulation of NK cells with phorbol ester (PMA) or with calcium ionophore A23187 also induced beta 1 integrin-mediated adhesion of these cells to fibronectin (FN)-coated plastic surfaces.	Tetradecanoylphorbol Acetate	126-129	integrin subunit beta 1	Homo sapiens	177-192
7929214-6	1994	Shc-PTP-PEST complex formation was stimulated 6-8-fold by the protein kinase C activator phorbol 12-myristate 13-acetate, while epidermal growth factor and serum had no effect.	Tetradecanoylphorbol Acetate	89-120	SHC adaptor protein 1	Homo sapiens	0-3
7943332-10	1994	Increased phosphorylation of the MARCKS and other TPA-regulated proteins suggests that CCK, carbachol, bombesin, and the CCK partial agonist, JMV-180, all activate protein kinase C in intact acini.	Tetradecanoylphorbol Acetate	50-53	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	33-39
7943332-10	1994	Increased phosphorylation of the MARCKS and other TPA-regulated proteins suggests that CCK, carbachol, bombesin, and the CCK partial agonist, JMV-180, all activate protein kinase C in intact acini.	Tetradecanoylphorbol Acetate	50-53	cholecystokinin	Rattus norvegicus	87-90
7943332-10	1994	Increased phosphorylation of the MARCKS and other TPA-regulated proteins suggests that CCK, carbachol, bombesin, and the CCK partial agonist, JMV-180, all activate protein kinase C in intact acini.	Tetradecanoylphorbol Acetate	50-53	cholecystokinin	Rattus norvegicus	121-124
7955078-0	1994	Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis.	Tetradecanoylphorbol Acetate	22-58	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-111
7955078-0	1994	Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis.	Tetradecanoylphorbol Acetate	22-58	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-121
7955078-3	1994	Treatment of quiescent JB6 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) (10 ng/ml) for 24 h markedly stimulated the formation of c-Jun and caused morphological changes.	Tetradecanoylphorbol Acetate	38-74	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-143
7955078-3	1994	Treatment of quiescent JB6 cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) (10 ng/ml) for 24 h markedly stimulated the formation of c-Jun and caused morphological changes.	Tetradecanoylphorbol Acetate	76-79	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-143
7955078-6	1994	The increased expression of c-Jun and morphological changes observed at 24 h after treatment of JB6 cells with TPA (10 ng/ml) was inhibited by curcumin (10 nmol/ml).	Tetradecanoylphorbol Acetate	111-114	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-33
7955078-11	1994	Topical application of 10 mumol curcumin together with 5 nmol TPA once a day for 5 days strongly inhibited TPA-induced epidermal hyperplasia and c-Jun and c-Fos expression.	Tetradecanoylphorbol Acetate	62-65	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	145-150
7955078-11	1994	Topical application of 10 mumol curcumin together with 5 nmol TPA once a day for 5 days strongly inhibited TPA-induced epidermal hyperplasia and c-Jun and c-Fos expression.	Tetradecanoylphorbol Acetate	62-65	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	155-160
21559644-1	1994	The ornithine decarboxylase (ODC), hydroperoxide (HPx) and DNA responses to 12-O-tetradecanoylphorbol-13-acetate (TPA) and mezerein (MEZ) are similar in vivo.	Tetradecanoylphorbol Acetate	76-112	ornithine decarboxylase, structural 1	Mus musculus	4-27
21559644-1	1994	The ornithine decarboxylase (ODC), hydroperoxide (HPx) and DNA responses to 12-O-tetradecanoylphorbol-13-acetate (TPA) and mezerein (MEZ) are similar in vivo.	Tetradecanoylphorbol Acetate	114-117	ornithine decarboxylase, structural 1	Mus musculus	4-27
7929831-5	1994	Moreover, melanocytes constitutively express low levels of trk-C, and its expression is downregulated after TPA stimulation.	Tetradecanoylphorbol Acetate	108-111	neurotrophic receptor tyrosine kinase 3	Homo sapiens	59-64
7827622-11	1994	However, this paper also shows that 12-O-tetradecanoylphorbol-13-acetate (TPA) which activates PKC also leads to the phosphorylation of CREB in oPT cells, suggesting the potential involvement of other signal transduction pathways in the transcriptional regulation of these cells.	Tetradecanoylphorbol Acetate	36-72	cAMP responsive element binding protein 1	Homo sapiens	136-140
7827622-11	1994	However, this paper also shows that 12-O-tetradecanoylphorbol-13-acetate (TPA) which activates PKC also leads to the phosphorylation of CREB in oPT cells, suggesting the potential involvement of other signal transduction pathways in the transcriptional regulation of these cells.	Tetradecanoylphorbol Acetate	74-77	cAMP responsive element binding protein 1	Homo sapiens	136-140
7931287-1	1994	Exposure of human SK-N-MC neurotumor cells to 4 beta-phorbol 12-myristate 13-acetate (PMA) increased isoproterenol stimulation of cyclic AMP levels by severalfold.	Tetradecanoylphorbol Acetate	48-84	hedgehog acyltransferase	Homo sapiens	18-22
7931287-1	1994	Exposure of human SK-N-MC neurotumor cells to 4 beta-phorbol 12-myristate 13-acetate (PMA) increased isoproterenol stimulation of cyclic AMP levels by severalfold.	Tetradecanoylphorbol Acetate	86-89	hedgehog acyltransferase	Homo sapiens	18-22
7916997-2	1994	More than 95% of tumors induced by initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) exhibited mutations in Ha-ras and trisomy of chromosome 7.	Tetradecanoylphorbol Acetate	108-145	Harvey rat sarcoma virus oncogene	Mus musculus	175-181
7916997-2	1994	More than 95% of tumors induced by initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) exhibited mutations in Ha-ras and trisomy of chromosome 7.	Tetradecanoylphorbol Acetate	147-150	Harvey rat sarcoma virus oncogene	Mus musculus	175-181
7827802-6	1994	In addition, TPA reversed the HGF effect in both normal hepatocytes and FaO HCC cells.	Tetradecanoylphorbol Acetate	13-16	hepatocyte growth factor	Rattus norvegicus	30-33
8074706-5	1994	We have shown that mRNA encoding hsp70RY is expressed in a variety of human cell lines and that mRNA expression remains unchanged in human promyelocytic HL-60 cells induced to differentiate with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	228-231	heat shock protein family A (Hsp70) member 4	Homo sapiens	33-40
8050593-4	1994	Following short stimulation (5 min) of PMN with phorbol-12-myristate-13-acetate (1 microgram/ml), physical translocation of PKC zeta from the cytosol to the plasma membrane fraction occurred, although this isoform does not bind phorbol esters.	Tetradecanoylphorbol Acetate	48-79	protein kinase C zeta	Homo sapiens	124-132
7520703-9	1994	In another set of experiments, we found that GAL mRNA levels could be induced more than 10-fold by 20-hr treatment with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	120-151	galanin and GMAP prepropeptide	Homo sapiens	45-48
7520703-9	1994	In another set of experiments, we found that GAL mRNA levels could be induced more than 10-fold by 20-hr treatment with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	153-156	galanin and GMAP prepropeptide	Homo sapiens	45-48
8035171-2	1994	Treatment of astrocytes with interleukin-1 beta (IL-1) or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased NGF mRNA content by six- to 10-fold, followed in time by increases in cell content and cell secretion of NGF.	Tetradecanoylphorbol Acetate	95-131	protein kinase C, gamma	Rattus norvegicus	62-78
8035171-2	1994	Treatment of astrocytes with interleukin-1 beta (IL-1) or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased NGF mRNA content by six- to 10-fold, followed in time by increases in cell content and cell secretion of NGF.	Tetradecanoylphorbol Acetate	95-131	protein kinase C, gamma	Rattus norvegicus	80-83
8035171-2	1994	Treatment of astrocytes with interleukin-1 beta (IL-1) or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased NGF mRNA content by six- to 10-fold, followed in time by increases in cell content and cell secretion of NGF.	Tetradecanoylphorbol Acetate	133-136	protein kinase C, gamma	Rattus norvegicus	62-78
8035171-2	1994	Treatment of astrocytes with interleukin-1 beta (IL-1) or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased NGF mRNA content by six- to 10-fold, followed in time by increases in cell content and cell secretion of NGF.	Tetradecanoylphorbol Acetate	133-136	protein kinase C, gamma	Rattus norvegicus	80-83
8035787-5	1994	This superinduction was blocked by preincubation of cells with the glutathione precursor N-acetyl cysteine or with phorbol 12-myristate 13-acetate, which indicates redox control of c-jun expression and probable involvement of protein kinase C. By gel retardation assay, no increase in AP-1 DNA binding activity was found to be concomitant with the transcriptional activation of c-jun.	Tetradecanoylphorbol Acetate	115-146	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	181-186
8035787-5	1994	This superinduction was blocked by preincubation of cells with the glutathione precursor N-acetyl cysteine or with phorbol 12-myristate 13-acetate, which indicates redox control of c-jun expression and probable involvement of protein kinase C. By gel retardation assay, no increase in AP-1 DNA binding activity was found to be concomitant with the transcriptional activation of c-jun.	Tetradecanoylphorbol Acetate	115-146	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	285-289
8035787-5	1994	This superinduction was blocked by preincubation of cells with the glutathione precursor N-acetyl cysteine or with phorbol 12-myristate 13-acetate, which indicates redox control of c-jun expression and probable involvement of protein kinase C. By gel retardation assay, no increase in AP-1 DNA binding activity was found to be concomitant with the transcriptional activation of c-jun.	Tetradecanoylphorbol Acetate	115-146	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	378-383
7947388-7	1994	TPA-induced LNCaP apoptosis was preceded by rapid yet transient induction of the early response transcription factors NGFI-A and c-fos.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	129-134
7947388-9	1994	TPA-induced expression of NGFI-A and c-fos and death of LNCaP cultures were blocked by pretreatment with staurosporine, a potent inhibitor of several protein kinases.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-42
7947388-10	1994	Based on these studies, we suggest that activation of a TPA-inducible kinase(s) mediates apoptosis of androgen-sensitive prostate cells by means of an intracellular pathway that may involve the transient activation of the early response transcription factors NGFI-A and c-fos.	Tetradecanoylphorbol Acetate	56-59	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	270-275
8013086-5	1994	The protein kinase C activators (12-O-tetradecanoylphorbol 13-acetate [TPA], phorbol 12,13-dibutyrate, and 1-oleyl-2-acetyl-rac-glycerol) induced c-fos mRNA expression, which was also potentiated by TGF-beta 1.	Tetradecanoylphorbol Acetate	33-69	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	146-151
8021256-3	1994	Upon stimulation by serum or EGF, endogenous PKC species showed no indication of activation such as translocation or down-regulation, whereas TPA or synthetic diacylglycerol caused activation of all these PKC species when judged by these criteria.	Tetradecanoylphorbol Acetate	142-145	protein kinase C, alpha	Rattus norvegicus	205-208
8021256-6	1994	On the other hand, TPA caused increased phosphorylation of all three PKC species.	Tetradecanoylphorbol Acetate	19-22	protein kinase C, alpha	Rattus norvegicus	69-72
8021256-7	1994	Overexpression of these PKC members by introduction of the corresponding cDNA expression plasmids resulted in the enhancement of the cell response to TPA when monitored in terms of transcriptional activation through TPA- or serum-responsive elements.	Tetradecanoylphorbol Acetate	150-153	protein kinase C, alpha	Rattus norvegicus	24-27
8021256-7	1994	Overexpression of these PKC members by introduction of the corresponding cDNA expression plasmids resulted in the enhancement of the cell response to TPA when monitored in terms of transcriptional activation through TPA- or serum-responsive elements.	Tetradecanoylphorbol Acetate	216-219	protein kinase C, alpha	Rattus norvegicus	24-27
8021256-9	1994	In contrast to these nonphysiological stimuli, serum (or EGF) stimulation of 3Y1 cells that overexpress the respective PKC members revealed a clear difference between cPKC and nPKC, in that overexpression of nPKC delta or nPKC epsilon resulted in a large increase in TPA- or serum-responsive element activation, whereas the overexpression of cPKC alpha increased activation only very slightly.	Tetradecanoylphorbol Acetate	267-270	protein kinase C, alpha	Rattus norvegicus	119-122
8021301-9	1994	In contrast, the acute treatment of control cells with TPA induced a decrease in both Tg and collagen content by factors 3.0 and 1.5, respectively, and an increase in thrombospondin content by a factor 2.5.	Tetradecanoylphorbol Acetate	55-58	transcription termination factor 2	Homo sapiens	195-203
8021301-13	1994	On TSH differentiated cells, TPA decreased both collagen and Tg accumulation by factors 1.2 and 1.8, respectively, whereas it increased the one of thrombospondin by a factor 2.	Tetradecanoylphorbol Acetate	29-32	transcription termination factor 2	Homo sapiens	167-175
7516333-7	1994	Pretreatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA) abrogated thrombin receptor [Ca2+]i signaling, and TRAP-induced Ca2+ entry was inhibited by the acute treatment with PMA.	Tetradecanoylphorbol Acetate	36-67	TRAP	Homo sapiens	125-129
7516333-7	1994	Pretreatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA) abrogated thrombin receptor [Ca2+]i signaling, and TRAP-induced Ca2+ entry was inhibited by the acute treatment with PMA.	Tetradecanoylphorbol Acetate	191-194	TRAP	Homo sapiens	125-129
8003009-2	1994	Addition of 10(-7) M PMA for 15 min stimulated the amount of PtBut formed in growth arrested cells by 3-4 fold whereas no stimulation was observed with 5000 units mL-1 CSF-1 for 0.5, 2 or 15 min.	Tetradecanoylphorbol Acetate	21-24	colony stimulating factor 1 (macrophage)	Mus musculus	168-173
8204888-7	1994	Agents that inhibit TNF-alpha expression in HL-60 cells, such as pentoxifylline and dexamethasone, completely abrogated both the constitutive and TPA-evoked MMP-9 release.	Tetradecanoylphorbol Acetate	146-149	matrix metallopeptidase 9	Homo sapiens	157-162
7911467-7	1994	In A549 cells, ICAM-1 mRNA is increased 10-20-fold by treatment of cells with the phorbol ester phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	96-127	intercellular adhesion molecule 1	Homo sapiens	15-21
7911467-8	1994	When PKC-alpha protein levels are depleted by oligonucleotide treatment of A549 cells, the increase in ICAM-1 expression in response to phorbol 12-myristate 13-acetate is greatly reduced, demonstrating that PKC-alpha plays a major role in this process.	Tetradecanoylphorbol Acetate	136-167	intercellular adhesion molecule 1	Homo sapiens	103-109
8020141-2	1994	Using dimethyl sulfate (DMS) genomic footprinting, in vivo, all protein binding sites in the c-jun promoter, including Jun1 and Jun2, are already fully occupied before induction and the protein--DNA contacts are unchanged during gene activation by TPA and UV and subsequent repression.	Tetradecanoylphorbol Acetate	248-251	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-98
8020141-7	1994	The lack of detectable changes in DNA binding and factor composition strongly suggests that transcriptional activation and subsequent inactivation of c-jun promoter activity by TPA or UV is mediated by post-translational modifications of prebound cJun and possibly ATF-2.	Tetradecanoylphorbol Acetate	177-180	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	150-155
8020141-7	1994	The lack of detectable changes in DNA binding and factor composition strongly suggests that transcriptional activation and subsequent inactivation of c-jun promoter activity by TPA or UV is mediated by post-translational modifications of prebound cJun and possibly ATF-2.	Tetradecanoylphorbol Acetate	177-180	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	247-251
8020141-7	1994	The lack of detectable changes in DNA binding and factor composition strongly suggests that transcriptional activation and subsequent inactivation of c-jun promoter activity by TPA or UV is mediated by post-translational modifications of prebound cJun and possibly ATF-2.	Tetradecanoylphorbol Acetate	177-180	activating transcription factor 2	Homo sapiens	265-270
8089198-4	1994	Furthermore, the activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) potentiated the effect of 1,25(OH)2D3 by 1 h. TPA appeared to exert its effect at a transcriptional step, since mRNA stability was not affected by TPA treatment.	Tetradecanoylphorbol Acetate	38-74	protein kinase C, gamma	Rattus norvegicus	31-34
8089198-4	1994	Furthermore, the activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) potentiated the effect of 1,25(OH)2D3 by 1 h. TPA appeared to exert its effect at a transcriptional step, since mRNA stability was not affected by TPA treatment.	Tetradecanoylphorbol Acetate	76-79	protein kinase C, gamma	Rattus norvegicus	31-34
8089198-4	1994	Furthermore, the activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) potentiated the effect of 1,25(OH)2D3 by 1 h. TPA appeared to exert its effect at a transcriptional step, since mRNA stability was not affected by TPA treatment.	Tetradecanoylphorbol Acetate	127-130	protein kinase C, gamma	Rattus norvegicus	31-34
8089198-4	1994	Furthermore, the activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) potentiated the effect of 1,25(OH)2D3 by 1 h. TPA appeared to exert its effect at a transcriptional step, since mRNA stability was not affected by TPA treatment.	Tetradecanoylphorbol Acetate	127-130	protein kinase C, gamma	Rattus norvegicus	31-34
8197173-3	1994	Upon differentiation of HL-60 cells to macrophages induced by phorbol 12-myristate 13-acetate (PMA), the activity and expression levels of PTP1C increase 2- to 3-fold.	Tetradecanoylphorbol Acetate	62-93	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	139-144
8197173-3	1994	Upon differentiation of HL-60 cells to macrophages induced by phorbol 12-myristate 13-acetate (PMA), the activity and expression levels of PTP1C increase 2- to 3-fold.	Tetradecanoylphorbol Acetate	95-98	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	139-144
7909823-6	1994	Primed cells are enriched in CD45R0hi and CD31- cells, and upon stimulation with PMA+ ionomycin they release significant amounts of IL-2, IFN-gamma, IL-4, IL-5, and IL-10.	Tetradecanoylphorbol Acetate	81-84	interleukin 10	Homo sapiens	165-170
8178929-3	1994	The addition of transforming growth factor-beta (TGF-beta) or phorbolester-TPA to sparse cultures induced low levels of MMP-9 secretion, whereas in confluent cultures only TGF-beta produced this effect.	Tetradecanoylphorbol Acetate	75-78	matrix metallopeptidase 9	Homo sapiens	120-125
8178929-5	1994	Treatment of sparse, actively growing cultures but not confluent stationary cultures with both TGF-beta and TPA produced synergistic induction of MMP-9 but did not affect MMP-2.	Tetradecanoylphorbol Acetate	108-111	matrix metallopeptidase 9	Homo sapiens	146-151
7524596-3	1994	All of the agents examined, including DOPPA (12-deoxyphorbol-13-O-phenylacetate-20 acetate), which is specific for the beta 1 isozyme in vitro, were able to mimic the effects of TPA.	Tetradecanoylphorbol Acetate	178-181	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	119-125
7948767-8	1994	On the other hand, the PAF antagonists used in this study interfere with the transduction of the signals induced by LPS, PMA or zymosan.	Tetradecanoylphorbol Acetate	121-124	PCNA clamp associated factor	Rattus norvegicus	23-26
8174632-11	1994	PMA also induced c-fos and c-jun with a time course similar to that of serum or thrombin.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-22
8174632-11	1994	PMA also induced c-fos and c-jun with a time course similar to that of serum or thrombin.	Tetradecanoylphorbol Acetate	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-32
8174632-12	1994	The induction of c-fos by PMA was sensitive to staurosporine or GF 109203X.	Tetradecanoylphorbol Acetate	26-29	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-22
8053392-9	1994	The production of PTHrP was stimulated by the protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA) by 82.9 +/- 9.7% (n = 4 experiments, p &lt; 0.01).	Tetradecanoylphorbol Acetate	79-110	parathyroid hormone-like hormone	Rattus norvegicus	18-23
8053392-9	1994	The production of PTHrP was stimulated by the protein kinase C (PKC) activator phorbol-12-myristate-13-acetate (PMA) by 82.9 +/- 9.7% (n = 4 experiments, p &lt; 0.01).	Tetradecanoylphorbol Acetate	112-115	parathyroid hormone-like hormone	Rattus norvegicus	18-23
8182143-4	1994	In PMA-stimulated neutrophils and in a cell-free translocation assay with neutrophil membranes and cytosol, the association of the cytosolic proteins p47-phox and p67-phox with the membrane fraction of the patient was strongly disturbed.	Tetradecanoylphorbol Acetate	3-6	neutrophil cytosolic factor 1	Homo sapiens	150-158
8046298-3	1994	Protein kinase C (PKC) inhibitors H-7 and staurosporine blocked this inhibitory effect of ACTH, whereas 12-0-tetradecanoyl phorbol-13-acetate (TPA; a PKC activator) mimicked the ACTH-induced antimitogenic effect.	Tetradecanoylphorbol Acetate	143-146	protein kinase C, gamma	Rattus norvegicus	150-153
8046298-9	1994	Reduction (50-75%) of cholesterol side-chain cleavage enzyme (P450scc) mRNA expression was also noted with H-7 in ACTH-treated cultures after 6 and 24 h. In contrast, TPA doubled the corticosterone secretion induced by 8-Br cAMP, but did not further increase the ACTH-induced secretion after 24 h. TPA alone, however, was not able to induce steroid secretion or P450scc mRNA expression.	Tetradecanoylphorbol Acetate	167-170	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	62-69
8046298-9	1994	Reduction (50-75%) of cholesterol side-chain cleavage enzyme (P450scc) mRNA expression was also noted with H-7 in ACTH-treated cultures after 6 and 24 h. In contrast, TPA doubled the corticosterone secretion induced by 8-Br cAMP, but did not further increase the ACTH-induced secretion after 24 h. TPA alone, however, was not able to induce steroid secretion or P450scc mRNA expression.	Tetradecanoylphorbol Acetate	298-301	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	62-69
8157958-5	1994	The phorbol ester, PMA, was also a potent inducer of Fos kinase activity in all of the above populations, suggesting that PKC plays a role in the regulation of this enzyme.	Tetradecanoylphorbol Acetate	19-22	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	53-56
7908992-5	1994	In contrast, interleukin-1 and phorbol myristate acetate exhibited variable effects on ICAM-1 expression, and interferon-alpha had no effect.	Tetradecanoylphorbol Acetate	31-56	intercellular adhesion molecule 1	Homo sapiens	87-93
8185825-2	1994	We observed that HK1.TGF alpha mice were highly sensitive to TPA promotion, exhibiting multiple papillomas as early as the third week of treatment.	Tetradecanoylphorbol Acetate	61-64	hexokinase 1	Mus musculus	17-20
8185825-6	1994	Both spontaneous and TPA-induced HK1.TGF alpha papillomas expressed c-Ha-ras message levels similar to those in normal, nontransgenic epidermis or HK1.TGF alpha hyperplastic epidermis.	Tetradecanoylphorbol Acetate	21-24	hexokinase 1	Mus musculus	33-36
8185825-6	1994	Both spontaneous and TPA-induced HK1.TGF alpha papillomas expressed c-Ha-ras message levels similar to those in normal, nontransgenic epidermis or HK1.TGF alpha hyperplastic epidermis.	Tetradecanoylphorbol Acetate	21-24	hexokinase 1	Mus musculus	147-150
7519562-1	1994	We examined the mechanisms involved in the activation of atrial natriuretic peptide (ANP) gene expression and secretion in response to acidic fibroblast growth factor (aFGF) by studying the effects of staurosporine, a protein kinase C inhibitor, and 12-O-tetradecanoyl phorbol 13-acetate (TPA), an activator of protein kinase C, on basal and AFGF-induced ANP messenger RNA (mRNA) and immunoreactive ANP (IR-ANP) levels in cultured neonatal rat cardiac myocytes.	Tetradecanoylphorbol Acetate	250-287	natriuretic peptide A	Rattus norvegicus	57-83
7519562-1	1994	We examined the mechanisms involved in the activation of atrial natriuretic peptide (ANP) gene expression and secretion in response to acidic fibroblast growth factor (aFGF) by studying the effects of staurosporine, a protein kinase C inhibitor, and 12-O-tetradecanoyl phorbol 13-acetate (TPA), an activator of protein kinase C, on basal and AFGF-induced ANP messenger RNA (mRNA) and immunoreactive ANP (IR-ANP) levels in cultured neonatal rat cardiac myocytes.	Tetradecanoylphorbol Acetate	250-287	natriuretic peptide A	Rattus norvegicus	85-88
8144618-4	1994	Like in man and rat, the expressions of collagenase I, stromelysin-1, and stromelysin-2 are regulated by the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate and by UV irradiation, but not by cAMP.	Tetradecanoylphorbol Acetate	124-161	matrix metallopeptidase 3	Rattus norvegicus	55-68
8145051-10	1994	Activation with phorbol myristate acetate in combination with Ca-ionophore induced IL-4 secretion in both populations, but preferentially in the CDw60+ subset, whereas the vast majority of interferon gamma was produced by the CDw60-CD8+ cells.	Tetradecanoylphorbol Acetate	16-41	CD8a molecule	Homo sapiens	232-235
8144923-6	1994	dbcAMP inhibited the TPA plus ionomycin-induced transcription of IL-2 and IL-2R genes in EL4 cells, suggesting interference with biochemic events downstream to PI hydrolysis and upstream to transcription of early activation genes.	Tetradecanoylphorbol Acetate	21-24	interleukin 2 receptor, alpha chain	Mus musculus	74-79
8078506-10	1994	Cyclin C expression was faint and fluctuated irrelevant of cell cycle, but its expression in both control and TPA-treated cells was higher than at baseline.	Tetradecanoylphorbol Acetate	110-113	cyclin C	Homo sapiens	0-8
8141770-3	1994	Activation of superoxide production by phorbol 12-myristate 13-acetate or formylmethionyl-leucyl-phenylalanine in whole cells, and by SDS in the cell-free assay, led to the dissociation of some of the p21rac2 from rhoGDI and its movement to the plasma membrane together with p47phox and p67phox.	Tetradecanoylphorbol Acetate	39-70	neutrophil cytosolic factor 1	Homo sapiens	275-282
8123649-2	1994	At 1 mumol/L, Lp(a) inhibited constitutive TPA secretion by 50% and phorbol myristate acetate- and histamine-enhanced TPA secretion by 40%.	Tetradecanoylphorbol Acetate	68-93	chromosome 20 open reading frame 181	Homo sapiens	118-121
7907090-0	1994	12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone.	Tetradecanoylphorbol Acetate	0-36	intercellular adhesion molecule 1	Homo sapiens	92-125
7907090-2	1994	Transcription regulation of the human intercellular adhesion molecule-1 gene by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), tumor necrosis factor alpha (TNF alpha), and the glucocorticoid dexamethasone was studied using transient transfections in 293 cells with intercellular adhesion molecule-1 promoter-luciferase constructs (together with a glucocorticoid receptor expression vector).	Tetradecanoylphorbol Acetate	98-134	intercellular adhesion molecule 1	Homo sapiens	38-71
7907090-2	1994	Transcription regulation of the human intercellular adhesion molecule-1 gene by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), tumor necrosis factor alpha (TNF alpha), and the glucocorticoid dexamethasone was studied using transient transfections in 293 cells with intercellular adhesion molecule-1 promoter-luciferase constructs (together with a glucocorticoid receptor expression vector).	Tetradecanoylphorbol Acetate	136-139	intercellular adhesion molecule 1	Homo sapiens	38-71
7907090-4	1994	Four TPA-responsive DNA regions were identified, each containing a potential TPA-responsive enhancer sequence: 1) -677/-340 an AP3-like sequence; 2) -290/278 a TPA-response element (TRE); 3) -227/-175 an NF kappa B-like sequence; 4) -105/-38 an AP2-like sequence.	Tetradecanoylphorbol Acetate	5-8	transcription factor AP-2 alpha	Homo sapiens	245-248
7906937-6	1994	The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 showed almost complete inhibition of the increase in intracellular peroxide levels of the endothelial cells exposed to PMA-stimulated leukocytes.	Tetradecanoylphorbol Acetate	184-187	intercellular adhesion molecule 1	Homo sapiens	58-64
8106362-10	1994	In addition to the distinct effects of 1,25-(OH)2-D3 and TPA on PKC isozyme patterns, 1,25-(OH)2-D3 up-regulates both the vitamin D receptor and calbindin D-28K, whereas TPA down-regulates the expression of both proteins.	Tetradecanoylphorbol Acetate	57-60	protein kinase C alpha	Bos taurus	64-67
7507730-8	1994	Binding of TPA-treated cells to hyaluronan is only partly inhibited by MoAb to CD44: this suggests that TPA may induce synthesis of a hyaluronan-binding protein distinct from CD44.	Tetradecanoylphorbol Acetate	11-14	CD44 molecule (Indian blood group)	Homo sapiens	79-83
7507730-8	1994	Binding of TPA-treated cells to hyaluronan is only partly inhibited by MoAb to CD44: this suggests that TPA may induce synthesis of a hyaluronan-binding protein distinct from CD44.	Tetradecanoylphorbol Acetate	104-107	CD44 molecule (Indian blood group)	Homo sapiens	79-83
7905497-7	1994	In response to primary stimulation with PMA and ionomycin, cells primed with IL-4 + IL-2 produce IL-4, IL-5, and IL-10 and the same levels of IL-2 and IFN-gamma as IL-4-primed cells.	Tetradecanoylphorbol Acetate	40-43	interleukin 10	Homo sapiens	113-118
7787883-1	1994	Treatment of nontransformed rat intestinal crypt epithelial IEC-6 cells with tetradecanoyl phorbol acetate (TPA) + calcium ionophore (A23187) induces both the synthesis of prostacyclin and the expression of the TIS10/PGS-2 gene, a primary response gene encoding a second form of prostaglandin synthase (PGS).	Tetradecanoylphorbol Acetate	77-106	decorin	Rattus norvegicus	217-222
7787883-1	1994	Treatment of nontransformed rat intestinal crypt epithelial IEC-6 cells with tetradecanoyl phorbol acetate (TPA) + calcium ionophore (A23187) induces both the synthesis of prostacyclin and the expression of the TIS10/PGS-2 gene, a primary response gene encoding a second form of prostaglandin synthase (PGS).	Tetradecanoylphorbol Acetate	108-111	decorin	Rattus norvegicus	217-222
7787883-2	1994	In addition to pharmacological induction by TPA + A23187, TIS10/PGS-2 message is also induced by the inflammatory cytokine interleukin 1-beta (IL-1 beta).	Tetradecanoylphorbol Acetate	44-47	decorin	Rattus norvegicus	64-69
8020569-7	1994	Nuclear transcription assays and functional analysis of the alpha X and alpha 4 promoter regions demonstrated that the transcription rate of the alpha X gene is considerably elevated after phorbol 12-myristate 13-acetate treatment of U937 cells, while that of alpha 4 is almost unaffected, suggesting that post-transcriptional mechanisms are causing the extremely low alpha 4 mRNA levels observed in differentiated U937 cells.	Tetradecanoylphorbol Acetate	189-220	immunoglobulin binding protein 1	Homo sapiens	72-79
8253522-8	1993	However, the Ca(2+)-ATPase inhibitor cyclopiazonic acid and the Ca2+ ionophore and weak ODC inducer A23187 mimic remarkably the HPx responses to TG and TPA.	Tetradecanoylphorbol Acetate	152-155	ornithine decarboxylase, structural 1	Mus musculus	88-91
8257426-2	1993	Evidence has been accumulated that in phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, the translocation to the plasma membrane of the cytosolic components p47phox and p67phox and the phosphorylation of p47phox are essential steps in activation of NADPH oxidase.	Tetradecanoylphorbol Acetate	38-69	neutrophil cytosolic factor 1	Homo sapiens	216-223
8257426-2	1993	Evidence has been accumulated that in phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, the translocation to the plasma membrane of the cytosolic components p47phox and p67phox and the phosphorylation of p47phox are essential steps in activation of NADPH oxidase.	Tetradecanoylphorbol Acetate	71-74	neutrophil cytosolic factor 1	Homo sapiens	169-176
8257426-2	1993	Evidence has been accumulated that in phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils, the translocation to the plasma membrane of the cytosolic components p47phox and p67phox and the phosphorylation of p47phox are essential steps in activation of NADPH oxidase.	Tetradecanoylphorbol Acetate	71-74	neutrophil cytosolic factor 1	Homo sapiens	216-223
7504022-0	1993	Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies.	Tetradecanoylphorbol Acetate	69-94	CD44 molecule (Indian blood group)	Homo sapiens	20-24
7504022-0	1993	Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies.	Tetradecanoylphorbol Acetate	69-94	CD44 molecule (Indian blood group)	Homo sapiens	30-34
8255104-11	1993	Cells exposed to phorbol myristate acetate (PMA) had increased expression of CD11a, CD11b, CD18, CD45RO, and HLA-DR, whereas expression of CD15 and CD30 was markedly decreased.	Tetradecanoylphorbol Acetate	17-42	integrin subunit alpha M	Homo sapiens	84-89
8255104-11	1993	Cells exposed to phorbol myristate acetate (PMA) had increased expression of CD11a, CD11b, CD18, CD45RO, and HLA-DR, whereas expression of CD15 and CD30 was markedly decreased.	Tetradecanoylphorbol Acetate	17-42	TNF receptor superfamily member 8	Homo sapiens	148-152
7693343-0	1993	Transforming growth factor beta 1 induction is associated with transforming growth factors beta 2 and beta 3 down-modulation in 12-O-tetradecanoylphorbol-13-acetate-induced skin hyperplasia.	Tetradecanoylphorbol Acetate	128-164	hemoglobin, beta adult minor chain	Mus musculus	91-108
8226872-3	1993	Binding sites for NF-kB, Sp-1, and AP-1 are reportedly required for induction of MMP-9 gene expression by tumor necrosis factor-alpha or 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	137-173	matrix metallopeptidase 9	Homo sapiens	81-86
8226882-3	1993	In transient transfection assays with a c-fos promoter reporter construct T3 decreased basal promoter activity by more than 50-60% and strongly inhibited the TPA and forskolin-induced activity.	Tetradecanoylphorbol Acetate	158-161	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	40-45
8409453-4	1993	HVS-transformed Th1 clones but not their uninfected counterparts spontaneously transcribed and secreted Th1-type cytokines (IL-2, IFN-gamma, and TNF-beta) and such a production was further enhanced by stimulation with either SRBC or PMA plus anti-CD3 mAb.	Tetradecanoylphorbol Acetate	233-236	negative elongation factor complex member C/D	Homo sapiens	16-19
8107331-0	1993	Phorbol myristate acetate inhibits the bradykinin-induced L-nitro-arginine insensitive endothelium-dependent relaxation of bovine coronary artery.	Tetradecanoylphorbol Acetate	0-25	kininogen 1	Bos taurus	39-49
7935358-5	1993	Treatment of cells with activators of protein kinase C, TPA or OAG for 60 min caused a significant reduction in communication that could be restored within 2-5 min by the subsequent injection of either the protein kinase C inhibitor or the protein kinase A catalytic subunit.	Tetradecanoylphorbol Acetate	56-59	protein kinase cAMP-activated catalytic subunit alpha	Homo sapiens	240-274
8264664-4	1993	When the TGF beta 1 promoter activity is induced by 12-O-tetradecanoyl phorbol13-acetate (an activator of AP-1-controlled gene transcription), this activity can be strongly repressed by retinoic acid receptor-alpha (RAR alpha), RAR beta, or retinoid X receptor-alpha (RXR alpha) as well as other members of the nuclear receptor family.	Tetradecanoylphorbol Acetate	52-88	retinoid X receptor alpha	Homo sapiens	241-266
8264664-4	1993	When the TGF beta 1 promoter activity is induced by 12-O-tetradecanoyl phorbol13-acetate (an activator of AP-1-controlled gene transcription), this activity can be strongly repressed by retinoic acid receptor-alpha (RAR alpha), RAR beta, or retinoid X receptor-alpha (RXR alpha) as well as other members of the nuclear receptor family.	Tetradecanoylphorbol Acetate	52-88	retinoid X receptor alpha	Homo sapiens	268-277
8241020-2	1993	By Northern analysis, preproGRP mRNA was stimulated by 4 beta-phorbol 12-myristate 13 alpha-acetate (PMA) in a concentration- and time-dependent manner in these cells.	Tetradecanoylphorbol Acetate	101-104	gastrin releasing peptide	Homo sapiens	22-31
8241020-3	1993	In cell line NCI-H209, the addition of 10(-6) M PMA increased a 0.9-kb mRNA after 8 h. An inactive phorbol ester, 4 alpha-PMA, had little effect on preproGRP mRNA.	Tetradecanoylphorbol Acetate	48-51	gastrin releasing peptide	Homo sapiens	148-157
7690324-5	1993	In contrast, neutrophil LECAM-1 showed rapid shedding upon stimulation with phorbol 12-myristate 13-acetate (PMA) or IL-8.	Tetradecanoylphorbol Acetate	76-107	selectin L	Rattus norvegicus	24-31
8359227-2	1993	A tumor promoter, TPA, induced a megakaryocyte marker, glycoprotein IIb/IIIa (GP IIb/IIIa) or IIIa (GP IIIa), but suppressed erythroid differentiation.	Tetradecanoylphorbol Acetate	18-21	integrin subunit alpha 2b	Homo sapiens	78-84
7689639-2	1993	We now report that hypoxia also dramatically inhibits the basal protein kinase C-mediated phosphorylation of myelin basic protein and myelin 2",3"-cyclic nucleotide phosphohydrolase by 80%, but that the inhibition of phosphorylation can be reversed by addition of a protein kinase C activator, phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	294-325	myelin basic protein	Rattus norvegicus	109-129
8247013-2	1993	These proteins enhance trans-activation by c-jun, and the c-erbA receptors in the presence of thyroid hormone repress TPA and c-jun induction of transcription.	Tetradecanoylphorbol Acetate	118-121	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	43-48
8402584-2	1993	Topical applications of the semisynthetic flavonoids, catechin dialkyl ketals and epicatechin-4-alkylsulphides inhibit TPA-induced ornithine decarboxylase (ODC) activity to a much greater degree than catechin or epicatechin.	Tetradecanoylphorbol Acetate	119-122	ornithine decarboxylase, structural 1	Mus musculus	131-154
8402584-2	1993	Topical applications of the semisynthetic flavonoids, catechin dialkyl ketals and epicatechin-4-alkylsulphides inhibit TPA-induced ornithine decarboxylase (ODC) activity to a much greater degree than catechin or epicatechin.	Tetradecanoylphorbol Acetate	119-122	ornithine decarboxylase, structural 1	Mus musculus	156-159
8102559-15	1993	TPA-activated B-CLL cells showed a 1.2- to 13-fold increased expression of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), lymphocyte function-associated antigen (LFA)-1, and LFA-3, whereas expression of HLA class II molecules increased up to 5 times.	Tetradecanoylphorbol Acetate	0-3	intercellular adhesion molecule 1	Homo sapiens	98-131
8102559-15	1993	TPA-activated B-CLL cells showed a 1.2- to 13-fold increased expression of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), lymphocyte function-associated antigen (LFA)-1, and LFA-3, whereas expression of HLA class II molecules increased up to 5 times.	Tetradecanoylphorbol Acetate	0-3	intercellular adhesion molecule 1	Homo sapiens	133-139
8349617-5	1993	The latent SL-2 proenzyme was isolated from 12-O-tetradecanoylphorbol-13-acetate-induced keratinocytes by immunoaffinity chromatography using a cross-reactive antibody raised against human SL-1.	Tetradecanoylphorbol Acetate	44-80	matrix metallopeptidase 10	Homo sapiens	11-15
8356057-1	1993	The SIS/PDGFB gene, encoding the B polypeptide of platelet-derived growth factor (PDGF-B), is transcriptionally activated (&gt; 50 fold) in human K562 erythroleukemia cells when they are induced to differentiate into megakaryocytic cells by treatment with phorbol 12-myristate 13-acetate ("tetradecanoylphorbol acetate," TPA).	Tetradecanoylphorbol Acetate	256-287	platelet derived growth factor subunit B	Homo sapiens	8-13
8356057-1	1993	The SIS/PDGFB gene, encoding the B polypeptide of platelet-derived growth factor (PDGF-B), is transcriptionally activated (&gt; 50 fold) in human K562 erythroleukemia cells when they are induced to differentiate into megakaryocytic cells by treatment with phorbol 12-myristate 13-acetate ("tetradecanoylphorbol acetate," TPA).	Tetradecanoylphorbol Acetate	256-287	platelet derived growth factor subunit B	Homo sapiens	82-88
8356057-1	1993	The SIS/PDGFB gene, encoding the B polypeptide of platelet-derived growth factor (PDGF-B), is transcriptionally activated (&gt; 50 fold) in human K562 erythroleukemia cells when they are induced to differentiate into megakaryocytic cells by treatment with phorbol 12-myristate 13-acetate ("tetradecanoylphorbol acetate," TPA).	Tetradecanoylphorbol Acetate	290-318	platelet derived growth factor subunit B	Homo sapiens	8-13
8356057-1	1993	The SIS/PDGFB gene, encoding the B polypeptide of platelet-derived growth factor (PDGF-B), is transcriptionally activated (&gt; 50 fold) in human K562 erythroleukemia cells when they are induced to differentiate into megakaryocytic cells by treatment with phorbol 12-myristate 13-acetate ("tetradecanoylphorbol acetate," TPA).	Tetradecanoylphorbol Acetate	290-318	platelet derived growth factor subunit B	Homo sapiens	82-88
8356057-1	1993	The SIS/PDGFB gene, encoding the B polypeptide of platelet-derived growth factor (PDGF-B), is transcriptionally activated (&gt; 50 fold) in human K562 erythroleukemia cells when they are induced to differentiate into megakaryocytic cells by treatment with phorbol 12-myristate 13-acetate ("tetradecanoylphorbol acetate," TPA).	Tetradecanoylphorbol Acetate	321-324	platelet derived growth factor subunit B	Homo sapiens	8-13
8356057-1	1993	The SIS/PDGFB gene, encoding the B polypeptide of platelet-derived growth factor (PDGF-B), is transcriptionally activated (&gt; 50 fold) in human K562 erythroleukemia cells when they are induced to differentiate into megakaryocytic cells by treatment with phorbol 12-myristate 13-acetate ("tetradecanoylphorbol acetate," TPA).	Tetradecanoylphorbol Acetate	321-324	platelet derived growth factor subunit B	Homo sapiens	82-88
8356057-2	1993	A 250-bp PDGF-B gene promoter attached to a reporter gene was shown to reproduce this TPA-induced activation.	Tetradecanoylphorbol Acetate	86-89	platelet derived growth factor subunit B	Homo sapiens	9-15
8356057-3	1993	In a series of mutants that we constructed, a 10-bp linker sequence was systematically moved across the 250-bp PDGF-B promoter sequence, and the effect upon luciferase reporter activity was measured to identify a site through which this TPA-induced transcriptional activation occurred.	Tetradecanoylphorbol Acetate	237-240	platelet derived growth factor subunit B	Homo sapiens	111-117
8356057-4	1993	We identified a site, which we named the SIS proximal element (SPE), at positions -58 to -39 relative to the PDGF-B mRNA initiation site that was essential for the TPA-induced activation.	Tetradecanoylphorbol Acetate	164-167	platelet derived growth factor subunit B	Homo sapiens	109-115
8356057-8	1993	In a time-course study, TPA induction of the endogenous PDGF-B mRNA and formation of the TPA-inducible complex occurred over the same time frame, and both events were specifically blocked by the addition of cycloheximide.	Tetradecanoylphorbol Acetate	24-27	platelet derived growth factor subunit B	Homo sapiens	56-62
8394087-3	1993	Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8.	Tetradecanoylphorbol Acetate	21-52	translocator protein	Homo sapiens	93-96
8394087-3	1993	Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8.	Tetradecanoylphorbol Acetate	21-52	integrin subunit alpha M	Homo sapiens	162-167
8348742-1	1993	During the phorbol myristate acetate (PMA)-induced differentiation of U937 cells to a macrophage-like phenotype, the levels of the heat shock proteins hsp90, hsp72 and hsp65 increased dramatically to a peak level following 24 h of treatment, and then declined.	Tetradecanoylphorbol Acetate	11-36	heat shock protein family D (Hsp60) member 1	Homo sapiens	168-173
8348742-1	1993	During the phorbol myristate acetate (PMA)-induced differentiation of U937 cells to a macrophage-like phenotype, the levels of the heat shock proteins hsp90, hsp72 and hsp65 increased dramatically to a peak level following 24 h of treatment, and then declined.	Tetradecanoylphorbol Acetate	38-41	heat shock protein family D (Hsp60) member 1	Homo sapiens	168-173
8360591-1	1993	In this report, we show that the p14 subunit of calcium-binding myeloid protein complex (p8,14) is phosphorylated in human neutrophils stimulated with either fMet-Leu-Phe, phorbol myristate acetate, or a calcium ionophore.	Tetradecanoylphorbol Acetate	172-197	ribonuclease P/MRP subunit p14	Homo sapiens	33-36
8232304-8	1993	The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, down-regulated the promoter activity by more than 80% and completely inhibited hTBG synthesis, whereas thyroid hormone, glucocorticoid, estrogen, and nicotinic acid had little, if any, effect.	Tetradecanoylphorbol Acetate	19-55	serpin family A member 7	Homo sapiens	136-140
8233727-11	1993	Considering the low proportion of lymphocytes, stimulation with phorbol myristate acetate in combination with ionomycin resulted in considerable production of the following lymphokines: IL-2, IL-3, IL-4, IL-10, interferon-gamma, tumor necrosis factor-alpha.	Tetradecanoylphorbol Acetate	64-89	interleukin 10	Homo sapiens	204-209
8364900-0	1993	Antipromoting effects of 5-lipoxygenase inhibitors, 3-nitro-2,4,6- trihydroxybenzamide derivatives, on TPA-promoted transformation in BALB 3T3 cells.	Tetradecanoylphorbol Acetate	103-106	arachidonate 5-lipoxygenase	Mus musculus	25-39
8364900-4	1993	Good correlations were observed between the inhibition of TPA-promoted transformation and that of 5-LO.	Tetradecanoylphorbol Acetate	58-61	arachidonate 5-lipoxygenase	Mus musculus	98-102
8346015-5	1993	12-O-tetradecanoylphorbol 13-acetate (TPA) induces the uPA gene through the same elements, but additionally utilizes an adjacent PEA3 element and induces c-fos.	Tetradecanoylphorbol Acetate	0-36	protein c-Fos	Sus scrofa	154-159
8346015-5	1993	12-O-tetradecanoylphorbol 13-acetate (TPA) induces the uPA gene through the same elements, but additionally utilizes an adjacent PEA3 element and induces c-fos.	Tetradecanoylphorbol Acetate	38-41	protein c-Fos	Sus scrofa	154-159
7694073-2	1993	Here we show that PMA induces c-fos with similar kinetics when compared with ACTH (0.5-1 h peak) but reaches only 60% of the maximal ACTH induction and dcAMP is a weak c-fos inducer (15% of ACTH).	Tetradecanoylphorbol Acetate	18-21	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-35
7694073-3	1993	However, combination of PMA and dcAMP has a synergistic effect leading to maximal c-fos induction.	Tetradecanoylphorbol Acetate	24-27	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-87
8323287-7	1993	TPA treatment increased the de novo synthesis of PHS-2 while dexamethasone treatment reduced the response to TPA.	Tetradecanoylphorbol Acetate	0-3	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	49-52
8323287-13	1993	Dexamethasone partially inhibited the induction of both PHS transcripts by TPA.	Tetradecanoylphorbol Acetate	75-78	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	56-59
8401327-3	1993	Putrescine also inhibited the TPA-induced ornithine decarboxylase (ODC) activity and lowered the free sulfhydryl content of TPA exposed mouse skin.	Tetradecanoylphorbol Acetate	30-33	ornithine decarboxylase, structural 1	Mus musculus	42-65
8401327-3	1993	Putrescine also inhibited the TPA-induced ornithine decarboxylase (ODC) activity and lowered the free sulfhydryl content of TPA exposed mouse skin.	Tetradecanoylphorbol Acetate	30-33	ornithine decarboxylase, structural 1	Mus musculus	67-70
8261132-5	1993	Treatment with PMA which stimulates neurite outgrowth but not survival affected p87 (increased its acidity) but not p48.	Tetradecanoylphorbol Acetate	15-18	inner membrane mitochondrial protein	Homo sapiens	80-83
8394254-8	1993	When the in vitro modulation of basal and FSH-dependent cAMP production by the PKC activator 12-O-tetradecanoylphorbol 13-acetate (TPA, 100 nmol/l) was studied, the substance alone was without effect at all ages studied.	Tetradecanoylphorbol Acetate	93-129	protein kinase C, beta	Rattus norvegicus	79-82
8394254-8	1993	When the in vitro modulation of basal and FSH-dependent cAMP production by the PKC activator 12-O-tetradecanoylphorbol 13-acetate (TPA, 100 nmol/l) was studied, the substance alone was without effect at all ages studied.	Tetradecanoylphorbol Acetate	131-134	protein kinase C, beta	Rattus norvegicus	79-82
8324890-10	1993	3) Phorbol 12-myristate 13-acetate (PMA) increased liver net glucose output (166 +/- 4 micrograms/min/g wet liver), and H-7, a protein kinase C inhibitor, blunted PMA-induced liver glucose output (140 +/- 2 micrograms/min/g wet liver, P &lt; .05).	Tetradecanoylphorbol Acetate	163-166	solute carrier family 9 member A2	Rattus norvegicus	120-123
8477800-5	1993	We found that CD69 is induced on NK cells not only by IL-2 and IFN-alpha but also by activation of the CD16 pathway, the interaction with NK target cells and the direct activation of PKC by phorbol 12-myristate 13-acetate (PMA), indicating that CD69 induction is associated to different NK activation pathways.	Tetradecanoylphorbol Acetate	223-226	Fc gamma receptor IIIa	Homo sapiens	103-107
8507443-3	1993	This effect appeared to operate through a consensus TPA (phorbol 12-myristate 13-acetate) response element (ie, AP-1 binding site) located approximately 235 base pairs upstream from the start site of transcription.	Tetradecanoylphorbol Acetate	52-55	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	112-116
8507443-3	1993	This effect appeared to operate through a consensus TPA (phorbol 12-myristate 13-acetate) response element (ie, AP-1 binding site) located approximately 235 base pairs upstream from the start site of transcription.	Tetradecanoylphorbol Acetate	57-88	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	112-116
8318951-3	1993	When the cells were exposed to 12-0-tetradecanoylphorbol-13-acetate (TPA) immunoreactivity for the beta 1 integrin subunit was slightly enhanced.	Tetradecanoylphorbol Acetate	69-72	integrin subunit beta 1	Homo sapiens	99-114
8318951-7	1993	The present results specify the effects of differentiation inducers on the integrin profile of K562 cells and excludes the comprehension that TPA would induce expression of the platelet integrin alpha IIb on their surface.	Tetradecanoylphorbol Acetate	142-145	integrin subunit alpha 2b	Homo sapiens	186-204
8386622-1	1993	In many different cell types treatment with phorbol esters (e.g. 4 beta-phorbol 12-myristate 13-acetate, PMA) leads to the activation of protein-kinase C (PKC) and subsequently to the activation of the activator-protein-1(AP-1)-responsive gene expression.	Tetradecanoylphorbol Acetate	67-103	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	202-221
8386622-1	1993	In many different cell types treatment with phorbol esters (e.g. 4 beta-phorbol 12-myristate 13-acetate, PMA) leads to the activation of protein-kinase C (PKC) and subsequently to the activation of the activator-protein-1(AP-1)-responsive gene expression.	Tetradecanoylphorbol Acetate	67-103	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	222-226
8386622-1	1993	In many different cell types treatment with phorbol esters (e.g. 4 beta-phorbol 12-myristate 13-acetate, PMA) leads to the activation of protein-kinase C (PKC) and subsequently to the activation of the activator-protein-1(AP-1)-responsive gene expression.	Tetradecanoylphorbol Acetate	105-108	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	202-221
8386622-1	1993	In many different cell types treatment with phorbol esters (e.g. 4 beta-phorbol 12-myristate 13-acetate, PMA) leads to the activation of protein-kinase C (PKC) and subsequently to the activation of the activator-protein-1(AP-1)-responsive gene expression.	Tetradecanoylphorbol Acetate	105-108	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	222-226
8386622-7	1993	The functional role of the increased AP-1 DNA-binding activity was studied by transfecting THP-1 cells with reporter constructs containing AP-1 sites [Col-TREx5/TK-CAT and IL-1 beta-X-CAT, which contains the putative 12-O-tetradecanoyl-phorbol-13-acetate(TPA)-responsive element of the IL-1 beta gene].	Tetradecanoylphorbol Acetate	217-254	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-41
8386622-7	1993	The functional role of the increased AP-1 DNA-binding activity was studied by transfecting THP-1 cells with reporter constructs containing AP-1 sites [Col-TREx5/TK-CAT and IL-1 beta-X-CAT, which contains the putative 12-O-tetradecanoyl-phorbol-13-acetate(TPA)-responsive element of the IL-1 beta gene].	Tetradecanoylphorbol Acetate	255-258	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-41
8482337-1	1993	The effects of the tumor promoter phorbol 12-myristate 13-acetate (PMA) on the proliferation, protein kinase C activity (PKC), and c-fos gene expression were examined in cultures of young and senescent (90-95% lifespan completed) WI-38 human diploid fibroblasts.	Tetradecanoylphorbol Acetate	67-70	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-136
8494821-2	1993	We previously reported that CLE2/GC-box (at positions -95 to -73, which is homologous to the NF-kappa B binding site) and CLE0 (at positions to -40) of the mouse GM-CSF promoter are essential for transcriptional activation in response to phorbol-12-myristate-13-acetate (PMA)/calcium ionophore (A23187).	Tetradecanoylphorbol Acetate	238-269	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	162-168
8314909-2	1993	12-o-tetradecanoyl 13-phorbol acetate (TPA) differentiated them to macrophage-like cells with induction of MMP-9, and tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) stimulated the production of MMP-9 by TPA-treated cells.	Tetradecanoylphorbol Acetate	39-42	matrix metallopeptidase 9	Homo sapiens	107-112
8314909-2	1993	12-o-tetradecanoyl 13-phorbol acetate (TPA) differentiated them to macrophage-like cells with induction of MMP-9, and tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) stimulated the production of MMP-9 by TPA-treated cells.	Tetradecanoylphorbol Acetate	39-42	matrix metallopeptidase 9	Homo sapiens	224-229
8102878-4	1993	Induction of dermatitis by topical application of PMA increased the expression of Ly-6.A2 on TCR gamma delta+ dendritic epidermal T cells and did not change its expression on keratinocytes.	Tetradecanoylphorbol Acetate	50-53	lymphocyte antigen 6 complex, locus A	Mus musculus	82-89
8455942-5	1993	In addition, transformation of rat embryo cells induced by an activated ras gene in the presence of the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) or by ras plus SV40 large T antigen is also inhibited by this dominant-negative mutant, suggesting that a member of the jun or fos family is involved in the pathways leading to transformation in these systems as well.	Tetradecanoylphorbol Acetate	119-156	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	290-293
8455942-5	1993	In addition, transformation of rat embryo cells induced by an activated ras gene in the presence of the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) or by ras plus SV40 large T antigen is also inhibited by this dominant-negative mutant, suggesting that a member of the jun or fos family is involved in the pathways leading to transformation in these systems as well.	Tetradecanoylphorbol Acetate	158-161	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	290-293
8453712-10	1993	Treatment of TPA-promoted mice with IFN-gamma, and to a lesser extent IFN-beta, weakly potentiated the TPA-dependent induction of epidermal ODC activity.	Tetradecanoylphorbol Acetate	13-16	ornithine decarboxylase, structural 1	Mus musculus	140-143
8453712-10	1993	Treatment of TPA-promoted mice with IFN-gamma, and to a lesser extent IFN-beta, weakly potentiated the TPA-dependent induction of epidermal ODC activity.	Tetradecanoylphorbol Acetate	103-106	interferon beta 1, fibroblast	Mus musculus	70-78
8453712-10	1993	Treatment of TPA-promoted mice with IFN-gamma, and to a lesser extent IFN-beta, weakly potentiated the TPA-dependent induction of epidermal ODC activity.	Tetradecanoylphorbol Acetate	103-106	ornithine decarboxylase, structural 1	Mus musculus	140-143
8436593-4	1993	Downregulation of protein kinase C (PKC) by high doses of phorbol esters or selective PKC inhibitors prevented the induction of this mRNA by NGF, suggesting that NGF and TPA act through a common PKC-dependent pathway.	Tetradecanoylphorbol Acetate	170-173	protein kinase C, gamma	Rattus norvegicus	86-89
8454955-12	1993	Stimulation with receptor-independent stimuli such as phorbol myristate acetate and ionomycin induced more pronounced mobilization of Mac-1 on eosinophils, but no differences were obtained if the mobilized pool was related to their total pool.	Tetradecanoylphorbol Acetate	54-79	integrin subunit alpha M	Homo sapiens	134-139
7683375-2	1993	We find that activators of protein kinase-A [cholera toxin plus 3-isobutyl-1-methylxanthine (CT+IBMX)] and protein kinase-C [12-O-tetradecanoylphorbol-13-acetate (TPA)] markedly synergize with E2 in ER-mediated transcriptional activation.	Tetradecanoylphorbol Acetate	125-161	estrogen receptor	Cricetulus griseus	199-201
7683375-6	1993	Immunoblots showed that TPA reduced ER levels to 30% of control values after 24 h, while CT+IBMX increased levels about 1.5-fold.	Tetradecanoylphorbol Acetate	24-27	estrogen receptor	Cricetulus griseus	36-38
8429024-5	1993	Gz alpha variants containing selected substitutions of alanine for serine residues were expressed in human kidney 293 cells, and the ability of each to be phosphorylated in response to phorbol 12-myristate 13-acetate was examined.	Tetradecanoylphorbol Acetate	185-216	G protein subunit alpha z	Homo sapiens	0-8
8429024-12	1993	We show here that under conditions promoting phorbol 12-myristate 13-acetate-stimulated phosphorylation of Gz alpha in permeabilized platelets, Gq alpha is not phosphorylated.	Tetradecanoylphorbol Acetate	45-76	G protein subunit alpha z	Homo sapiens	107-115
8381412-3	1993	PKC activation by either 12-O-tetradecanoylphorbol-13-acetate (TPA) or by alpha-adrenoreceptor (phenylephrine plus propranolol) stimulation results in phosphorylation of the same two proteins to similar extents.	Tetradecanoylphorbol Acetate	25-61	protein kinase C, gamma	Rattus norvegicus	0-3
8381412-3	1993	PKC activation by either 12-O-tetradecanoylphorbol-13-acetate (TPA) or by alpha-adrenoreceptor (phenylephrine plus propranolol) stimulation results in phosphorylation of the same two proteins to similar extents.	Tetradecanoylphorbol Acetate	63-66	protein kinase C, gamma	Rattus norvegicus	0-3
8381412-4	1993	Two-dimensional phosphopeptide mapping shows that the same sites in TnI are modified by PKC in vitro and in TPA- or alpha-agonist-stimulated cells.	Tetradecanoylphorbol Acetate	108-111	protein kinase C, gamma	Rattus norvegicus	88-91
8435870-5	1993	Intraperitoneal injection of 10 or 30 mumol curcumin 1h before topical application of 5 nmol TPA inhibited TPA-induced increases in epidermal ODC enzyme activity by 75 or 89% respectively.	Tetradecanoylphorbol Acetate	93-96	ornithine decarboxylase, structural 1	Mus musculus	142-145
8435870-5	1993	Intraperitoneal injection of 10 or 30 mumol curcumin 1h before topical application of 5 nmol TPA inhibited TPA-induced increases in epidermal ODC enzyme activity by 75 or 89% respectively.	Tetradecanoylphorbol Acetate	107-110	ornithine decarboxylase, structural 1	Mus musculus	142-145
8435870-7	1993	The results indicate that curcumin inhibits TPA-induced increases in epidermal ODC enzyme activity by inhibiting the synthesis and/or enhancing the breakdown of ODC mRNA.	Tetradecanoylphorbol Acetate	44-47	ornithine decarboxylase, structural 1	Mus musculus	79-82
8435870-7	1993	The results indicate that curcumin inhibits TPA-induced increases in epidermal ODC enzyme activity by inhibiting the synthesis and/or enhancing the breakdown of ODC mRNA.	Tetradecanoylphorbol Acetate	44-47	ornithine decarboxylase, structural 1	Mus musculus	161-164
8425487-1	1993	In rat adipocytes, chronic incubation with 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced immunoreactive protein kinase-C (PKC) beta, gamma, delta, and zeta isoforms by 40-60% and PKC alpha by 75%, but had little effect on PKC epsilon levels.	Tetradecanoylphorbol Acetate	43-79	protein kinase C, beta	Rattus norvegicus	109-160
8425487-1	1993	In rat adipocytes, chronic incubation with 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced immunoreactive protein kinase-C (PKC) beta, gamma, delta, and zeta isoforms by 40-60% and PKC alpha by 75%, but had little effect on PKC epsilon levels.	Tetradecanoylphorbol Acetate	43-79	protein kinase C, alpha	Rattus norvegicus	184-193
8425487-1	1993	In rat adipocytes, chronic incubation with 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced immunoreactive protein kinase-C (PKC) beta, gamma, delta, and zeta isoforms by 40-60% and PKC alpha by 75%, but had little effect on PKC epsilon levels.	Tetradecanoylphorbol Acetate	43-79	protein kinase C, alpha	Rattus norvegicus	127-130
8425487-1	1993	In rat adipocytes, chronic incubation with 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced immunoreactive protein kinase-C (PKC) beta, gamma, delta, and zeta isoforms by 40-60% and PKC alpha by 75%, but had little effect on PKC epsilon levels.	Tetradecanoylphorbol Acetate	81-84	protein kinase C, beta	Rattus norvegicus	109-160
8425487-1	1993	In rat adipocytes, chronic incubation with 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced immunoreactive protein kinase-C (PKC) beta, gamma, delta, and zeta isoforms by 40-60% and PKC alpha by 75%, but had little effect on PKC epsilon levels.	Tetradecanoylphorbol Acetate	81-84	protein kinase C, alpha	Rattus norvegicus	184-193
8425487-1	1993	In rat adipocytes, chronic incubation with 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced immunoreactive protein kinase-C (PKC) beta, gamma, delta, and zeta isoforms by 40-60% and PKC alpha by 75%, but had little effect on PKC epsilon levels.	Tetradecanoylphorbol Acetate	81-84	protein kinase C, alpha	Rattus norvegicus	127-130
8425487-3	1993	Acute treatment with insulin induced the translocation of PKC beta in the myocytes both before and after chronic TPA treatment, but had no acute effect on the alpha or zeta isoforms.	Tetradecanoylphorbol Acetate	113-116	protein kinase C, beta	Rattus norvegicus	58-66
8425487-5	1993	The differential effects of chronic TPA treatment on the down-regulation of PKC beta may explain why insulin continues to activate biological processes in TPA-treated BC3H-1 myocytes, but not in adipocytes.	Tetradecanoylphorbol Acetate	36-39	protein kinase C, beta	Rattus norvegicus	76-84
8425487-5	1993	The differential effects of chronic TPA treatment on the down-regulation of PKC beta may explain why insulin continues to activate biological processes in TPA-treated BC3H-1 myocytes, but not in adipocytes.	Tetradecanoylphorbol Acetate	155-158	protein kinase C, beta	Rattus norvegicus	76-84
8430775-5	1993	Both PMA and PDGF increased c-fos induction to the same magnitude; however, treatment with PMA did not induce DNA synthesis in these cells.	Tetradecanoylphorbol Acetate	5-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-33
8374508-6	1993	Vitamin E succinate plus suboptimal levels of the protein kinase C (PKC) activator phorbol myristate acetate (PMA) induced the highest levels of IL-2 by EL-4 cells.	Tetradecanoylphorbol Acetate	83-108	epilepsy 4	Mus musculus	153-157
8374508-6	1993	Vitamin E succinate plus suboptimal levels of the protein kinase C (PKC) activator phorbol myristate acetate (PMA) induced the highest levels of IL-2 by EL-4 cells.	Tetradecanoylphorbol Acetate	110-113	epilepsy 4	Mus musculus	153-157
7686084-5	1993	A similar increase in the absolute amount of c-fos mRNA was induced by a mixture of growth factors (epidermal growth factor/insulin/transferrin) and of c-myc mRNA with 12-O-tetradecanoylphorbolacetate.	Tetradecanoylphorbol Acetate	168-200	protein c-Fos	Sus scrofa	45-50
7686084-5	1993	A similar increase in the absolute amount of c-fos mRNA was induced by a mixture of growth factors (epidermal growth factor/insulin/transferrin) and of c-myc mRNA with 12-O-tetradecanoylphorbolacetate.	Tetradecanoylphorbol Acetate	168-200	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	152-157
7686084-8	1993	In contrast, with growth factors and 12-O-tetradecanoyl-phorbolacetate the maximum transcript levels were detected after 0.5 hr (c-fos) and 1 hr (c-myc), respectively; thereafter, a slight decrease was observed up to the end of the incubation time.	Tetradecanoylphorbol Acetate	37-70	protein c-Fos	Sus scrofa	129-134
7686084-8	1993	In contrast, with growth factors and 12-O-tetradecanoyl-phorbolacetate the maximum transcript levels were detected after 0.5 hr (c-fos) and 1 hr (c-myc), respectively; thereafter, a slight decrease was observed up to the end of the incubation time.	Tetradecanoylphorbol Acetate	37-70	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	146-151
8274300-5	1993	Treatment with TPA caused an increase in PDGF-A expression and in addition, an induction of PDGF-B transcripts were seen.	Tetradecanoylphorbol Acetate	15-18	platelet derived growth factor subunit A	Homo sapiens	41-47
8274300-5	1993	Treatment with TPA caused an increase in PDGF-A expression and in addition, an induction of PDGF-B transcripts were seen.	Tetradecanoylphorbol Acetate	15-18	platelet derived growth factor subunit B	Homo sapiens	92-98
8466753-4	1993	Since in the promoter region of the VEGF gene there are four potential AP-1 sites and two potential AP-2 sites we have studied if TPA and forskolin could regulate VEGF gene expression.	Tetradecanoylphorbol Acetate	130-133	vascular endothelial growth factor A	Bos taurus	163-167
8466753-5	1993	TPA induces VEGF transcription in a time- and dose-dependent fashion.	Tetradecanoylphorbol Acetate	0-3	vascular endothelial growth factor A	Bos taurus	12-16
8466753-6	1993	Maximal VEGF mRNA levels are detected 6 h after TPA treatment.	Tetradecanoylphorbol Acetate	48-51	vascular endothelial growth factor A	Bos taurus	8-12
15278495-0	1993	Modification of hepatic protein kinase C with phorbol myristate acetate and staurosporine alters hemodynamics in the perfused rat liver.	Tetradecanoylphorbol Acetate	46-71	protein kinase C, gamma	Rattus norvegicus	24-40
15278495-2	1993	Since hepatic blood flow and metabolism have been known to be altered in endotoxicosis and sepsis, we studied the hemodynamic effect of PKC modulation with phorbol 12-myristate 13-acetate (PMA) and staurosporine (St) on the perfused rat liver.	Tetradecanoylphorbol Acetate	156-187	protein kinase C, gamma	Rattus norvegicus	136-139
8352882-8	1993	After treatment with TPA, MEK cultures produced a large induction of both c-jun and c-fos mRNA by 60 min, as determined by northern blot analysis, and a large induction of ODC mRNA and enzyme activity by 6 h. TPA treatment of cultured HEKs, however, did not induce ODC activity; in fact, less activity, compared with that of control cultures, was observed.	Tetradecanoylphorbol Acetate	21-24	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-79
8352882-8	1993	After treatment with TPA, MEK cultures produced a large induction of both c-jun and c-fos mRNA by 60 min, as determined by northern blot analysis, and a large induction of ODC mRNA and enzyme activity by 6 h. TPA treatment of cultured HEKs, however, did not induce ODC activity; in fact, less activity, compared with that of control cultures, was observed.	Tetradecanoylphorbol Acetate	21-24	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	84-89